bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the perceived negative and positive long‐term impact of adolescent bullying victimization: A cross‐national investigation
Authors: Pabian Sara , Dehue Francine , Völlink Trijntje , Vandebosch Heidi 
Published: November 2021

AbstractAdolescent bullying victimization can have long‐term mental health and well‐being outcomes. This study focused on the potential mediating role of the perceived long‐term negative and positive impact of adolescent bullying victimization to understand its relations with mental health and well‐being problems during emerging adulthood. A retrospective study consisting of closed and open‐ended questions was conducted among 1010 Flemish and 650 Dutch emerging adults aged 18–26. Path analyses among early victims (NFlemish = 644; NDutch = 217) demonstrated that the relations between bullying victimization intensity and current self‐esteem, social interaction anxiety, and life satisfaction were all mediated by the perceived negative long‐term impact of adolescent bullying victimization. Additionally, the open‐ended questions provided a better understanding of the perceived negative and positive impact of adolescent bullying victimization. The present study offers insights into the importance of considering subjective perceptions of the overall impact of being bullied to understand long‐term bullying victimization outcomes. Implications and limitations are discussed, including the need for longitudinal data—for instance, a three‐wave panel study—to establish the temporal order of effects.
Significance of Flexible Substrates for Wearable and Implantable Devices: Recent Advances and Perspectives
Authors: Hassan Muhammad , Abbas Ghulam , Li Ning , Afzal Annum , Haider Zeeshan , Ahmed Saad , Xu Xiuru , Pan Caofeng , Peng Zhengchun 
Published: November 2021

AbstractIn the past decade, flexible electronics have attracted significant research attention due to their distinct features and emerging applications in numerous fields such as, flexible displays, implantable sensors, and energy storage systems, among other applications. Due to the development of flexible electronics, this paper details the substrates employed to produce flexible electronic devices, given that substrates generally govern the overall device properties. The increase in research attention can be attributed to the use of films as flexible substrates, which enable the implementation of numerous design strategies and engineering methodologies, thus leading to extensive advances in the manufacturing quality and prospect of flexible electronics in various applications. This paper provides a comprehensive review of the significance of substrates in flexible wearable electronics over the past decade, such as, the substrate properties requirements, processing classification, important flexible devices, and applications, including sensing, energy storage, and other electronic devices.
Organic Light‐Emitting Diode Based Fluorescence Sensing System for DNA Detection
Authors: Lian Cheng , Yoshida Kou , Nogues Claude , Samuel Ifor D. W. 
Published: November 2021

AbstractConventional fluorescence sensing equipment for disease detection is expensive and bulky, restricting access of patients to accurate diagnosis. Organic light‐emitting diodes (OLEDs) have the potential to enable compact fluorescence sensing compatible with point‐of‐care (POC) testing. However, the limited brightness and broad emission spectra of OLEDs can be a challenge for achieving good sensitivity. Here, co‐host microcavity OLEDs with narrowed spectra, high conductivity, and high brightness are developed for fluorescence sensing. The OLEDs are driven in pulsed mode for achieving higher brightness and stable light output. To sense the presence of single‐stranded DNA (ssDNA), two complementary ssDNA labelled with Cyanine dyes – Cy3 (ssDNA‐Cy3) or Cy5 (ssDNA‐Cy5) are used to form a Förster resonance energy transfer (FRET) pair when the DNA hybridized. The dye‐labelled DNA is then excited by the OLED at the Cy3 excitation wavelength, and the fluorescence is detected at the emission wavelength of Cy5. As a result, the device shows a very high sensitivity that can detect as low as 1 × 10−9 m of ssDNA‐Cy5 in fetal bovine serum (FBS). This work shows a simple approach to highly sensitive fluorescence sensing with OLED light sources that is promising for use in POC diagnostics.
High‐Accuracy and Broadband Wavelength Sensor with Detection Region Ranging from Deep Ultraviolet to Near Infrared Light
Authors: Li Chun‐Yan , Xiao Yu‐Tian , Fu Can , Liang Feng‐Xia , Chen Li‐Miao , Wu Di , Luo Lin‐Bao 
Published: November 2021

AbstractIn this paper, a broadband wavelength sensor which is composed of two horizontally stacked photodetectors is reported. The top part is a monolayer graphene (MLG)/thin Si/MLG heterojunction device and the bottom part is a MLG/Ge Schottky junction device. Owing to the thin thickness of the Si and the wavelength‐dependent absorption coefficients of both Si and Ge, the two photodetectors exhibit sharp contrast in photon‐generation rate when illuminated with different wavelengths of light. This distinction in photon generation leads to completely different evolution in photocurrent, and the corresponding relationship between the photocurrent ratio and wavelength can be easily expressed as a monotonic function, via which the wavelength in a broad range from deep ultraviolet (265 nm) to near infrared light (1550 nm) can be easily calculated. Notably, the average relative error and the average absolute error of the wavelength sensor are estimated to be 2.1% and 2.3 nm, respectively, which are much better than previously reported values.
Liquid Phase‐Induced Solid Solution Phase Mechanisms for Highly Stable and Ultrafast Energy Storage
Authors: Huang Meng , Zhu Jiexin , Yu Ruohan , Liu Yu , Liu Xiong , Wu Jinsong , An Qinyou , Mai Liqiang 
Published: November 2021

AbstractPhase transitions induce large changes of the lattice parameters, and thus have negative effects on the electrochemical energy storage of electrode materials. In contrast, solid solution phase energy storage mechanisms can ensure smaller shrinkage/expansion of the structure, and therefore better cyclability and fast reaction kinetics of the electrode materials. In this work, the liquid phase is found to control the energy storage mechanisms of K2.55Zn3.08[Fe(CN)6]2·0.28H2O (KZnHCF). Via in situ characterization techniques, phase‐transition and a solid solution phase hybrid mechanism with large chemical structural decay are observed in electrolytes with low K+ concentration, while only a solid solution phase type with a highly stable structure occurs in 5.0 m KCF3SO3 and 3.0 m KCF3SO3+2.0 m Zn(CF3SO3)2 electrolytes. Consequently, the solid solution phase ionic storage mechanism ensures a high rate capability at 20 A g−1 (capacity retention of 66.6%) and a long cyclability of 10 000 cycles (capacity retention of 93.7%) of the KZnHCF cathode.
Investigation of x‐ray response for flexible nanocomposite membranes of metal oxides and poly(vinyl alcohol)
Authors: Ayesh Ahmad I. , Salah Belal , Nawwas Rama , Almarri Asmaa S. , Al‐Thani Aisha N. , Al‐Ahbabi Alanoud M. , Al Haidous Noof A. 
Published: November 2021

AbstractIn this work, flexible composite membranes of nanoparticles (CuO, ZnO, or both), poly(vinyl alcohol) (PVA), and glycerol (GL) plasticizer are fabricated of for X‐ray detector applications. The nanoparticles are synthesized by a modified solvothermal technique and introduced to PVA + GL solution to fabricate the membranes. The mean sizes of nanoparticles are and , for CuO and ZnO in order. The composition of nanoparticles and membranes are investigated by energy dispersive x‐ray spectroscopy and x‐ray spectroscopy. Increasing nanoparticle concentration within the membranes causes their glass transition temperature to shift to low temperatures and enhances their thermal resistance. Fourier‐transform infrared spectroscopy demonstrates the formation of hydrogen bonds between nanoparticles and PVA that are generated by the intermolecular and intramolecular hydrogen bonds. Impedance spectroscopy characterization reveals that the membranes hold negative temperature coefficient of the resistance. The activation energy decreases with increasing nanoparticle concentration. The composite membranes exhibit a decent response to x‐ray that is proportional to its energy. The best x‐ray response is for the membranes with both CuO and ZnO nanoparticles, because of their different bandgaps that cause a wide range of excitation energy to be involved. The fabricated membranes have numerous advantages such as their semiconductor features, flexibility, and feasibility of fabrication on a large scale with reasonable cost.
HER2 targeting near‐infrared photoimmunotherapy for a CDDP‐resistant small‐cell lung cancer
Authors: Takahashi Kazuomi , Taki Shunichi , Yasui Hirotoshi , Nishinaga Yuko , Isobe Yoshitaka , Matsui Toshinori , Shimizu Misae , Koike Chiaki , Sato Kazuhide 
Published: November 2021

AbstractBackgroundHuman epidermal growth factor receptor 2 (HER2) is tyrosine kinase receptor that belongs to the ErbB family and is overexpressed on the membrane surface of various cancer cells, including small cell lung cancer (SCLC); however, no HER2 targeted therapy for SCLC have yet been established. Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel cancer therapy based on photo‐absorber, IRDye‐700DX (IR700), ‐antibody conjugates, and near‐infrared (NIR) light.MethodsWe used HER2‐positive SCLC parental cell lines (SBC‐3) and its chemoresistant cell lines, and examined therapeutic efficacy of HER2 targeting NIR‐PIT using anti HER2 antibody trastuzumab.ResultsWe found that HER2 expression was upregulated on chemoresistant cell lines, especially cisplatin‐resistance (SBC‐3/CDDP). In vitro, the rate of cell death increased with the amount of NIR‐light irradiation, and it was significantly higher in SBC‐3/CDDP than in SBC‐3. In vivo, tumor growth was more suppressed in SBC‐3/CDDP group than in SBC‐3 group, and survival period tended to be prolonged.ConclusionIn this study, we demonstrated that HER2 targeting NIR‐PIT using trastuzumab is promising therapy for HER2‐positive SCLC, and is more effective when HER2 expression is upregulated due to CDDP resistance, suggesting that the HER2 expression level positively corelated with the efficacy of NIR‐PIT.
Ecophysiological modeling of yield and yield components in winter wheat using hierarchical Bayesian analysis
Authors: Poudel Pratishtha , Bello Nora M. , Marburger David A. , Carver Brett F. , Liang Ye , Alderman Phillip D. 
Published: November 2021

AbstractYield components are widely recognized as drivers of wheat (Triticum aestivum L.) yield across environments and genotypes. In this study, we used a hierarchical Bayesian approach to model wheat grain yield in Oklahoma on an eco‐physiological basis using yield component traits thousand kernel weight (TKW) and nonyield biomass (NYB). The Bayesian approach allowed us to quantify uncertainties around the parameter values rather than obtaining a single value estimate for a parameter. The main objectives of this study were to (a) explain wheat yield as a function of component traits TKW and NYB, and thereby examine the implications for source‐sink balance; and (b) assess their association with weather conditions during key stages of wheat development. A secondary objective was to introduce Bayesian estimation for eco‐physiological modeling. Fifteen wheat genotypes planted in three locations in Oklahoma (Altus, Chickasha, and Lahoma) were evaluated across three harvest years (2017 to 2019), whereby the combination of location and year defined an environment. Results indicate that the environment explained a greater proportion of the variability in yield than genotypes or than genotype × environment (G × E) interaction; however, evidence for G × E was substantial. Yield was expected to increase with increasing TKW and NYB, which would suggest a source limitation to achieve potential yield. Yet, the contribution of early reproductive stage weather variables to the relationship between yield and NYB pointed in the direction of sink strength being compromised. In summary, our approach provides evidence for source‐sink co‐limitation in grain yield of this sample of hard red winter wheat genotypes.
IFN‐γ facilitates liver fibrogenesis by CD161+CD4+ T cells through a regenerative IL‐23/IL‐17 axis in chronic hepatitis B virus infection
Authors: Li Jing , Cheng Lisha , Jia Haoyu , Liu Chun , Wang Siqi , Liu Yun , Shen Yue , Wu Shengdi , Meng Fanli , Zheng Beishi , Yang Changqing , Jiang Wei 
Published: November 2021

AbstractObjectivesThis study aimed to determine the role of CD161+CD4+ T cells in chronic hepatitis B virus (HBV) infection.MethodsA total of 94 patients with chronic hepatitis B (CHB), 73 with liver cirrhosis (LC) and 28 healthy controls were enrolled to determine frequency, cytokine production and chemokine receptor expression of circulating CD161+CD4+ T cells. Among these, 50 CHB and 34 LC patients were followed up for a period of 52‐week entecavir monotherapy to assess the association of CD161+CD4+ T cells with seroconversion of HBV e antigen (HBeAg). In addition, 15 patients with hepatocellular carcinoma (HCC) and 15 with hepatic haemangioma (HHA) were enrolled to compare the paired circulating and intrahepatic CD161+CD4+ T cells.ResultsCD161+CD4+ T cells were found to accumulate in the circulation of HBV cohorts, which showed a significant correlation with the clinical parameters of disease progression. In addition, higher numbers of circulating CD161+CD4+ T cells were associated with an improved serological response of HBeAg to antiviral treatment. Moreover, CD161+CD4+ T cells as compared to homologous CD161‐CD4+ T cells produced more pro‐inflammatory cytokines including interleukin (IL)‐17 and interferon (IFN)‐γ and expressed higher levels of liver‐homing chemokine receptors including CCR6, CXCR6 and CX3CR1. Notably, a significant enrichment of CD161+CD4+ T cell subsets co‐expressing IFN‐γ and IL‐17 was observed in HBV‐associated cirrhotic livers. During in vitro co‐cultures, circulating CD161+CD4+ T cells in the chronic HBV setting exhibited prominent pro‐fibrogenic effects by regulating primary hepatic stellate cells through a regenerative IFN‐γ/IL‐23/IL‐17 axis.ConclusionsIn chronic HBV infection, CD161+CD4+ T cells play antiviral, pro‐inflammatory and pro‐fibrogenic roles.
Association between physical activity before diagnosis and the presence of clinical remission in type 1 diabetes – InlipoDiab1 study
Authors: Flotyńska Justyna , Jaz Kamila , Cieluch Aleksandra , Grzelka‐Woźniak Agata , Kaczmarek Anita , Pypeć Aleksandra , Ciepłucha Wiktoria , Nowicka Aleksandra , Zozulińska‐Ziółkiewicz Dorota , Uruska Aleksandra 
Published: November 2021

AbstractAimTo investigate whether physical activity is associated with the occurrence of remission in adults with type 1 diabetes.MethodsNinety nine adult participants with newly diagnosed type 1 diabetes were enroled into a prospective, observational study. The participants were advised to exercise 2–3 times a week with moderate intensity for a one‐year period. Physical activity was assessed by a self‐administrated questionnaire on every fourth visit. We counted the months in which participants fulfiled a partial‐remission criteria: HbA1c < 6.5%, C‐peptide > 0.5 ng/ml, and daily dose of insulin <0.3 U/kg/day. We assigned the participants to two groups: MORE EFFORT and LESS EFFORT, depending on the median value of physical activity in the studied population.ResultsThe occurrence of the remission achieved statistical significance at 6th month with a greater prevalence in MORE EFFORT group (55% vs. 35% p = 0.047). In multivariate logistic regression analysis for the occurrence of remission at 12th month, physical activity before the diagnosis was the only variable that influences the occurrence of the remission (adjusted odds ratios = 3.32 [95% confidence intervals 1.25–8.80]; p = 0.02).ConclusionIn adults with newly diagnosed type 1 diabetes physical activity before the diagnosis is associated with higher occurrence of remission.
Shift in competitive ability mediated by soil biota in an invasive plant
Authors: Huang Fangfang , Huang Qiaoqiao , Gan Xianhua , Zhang Weiqiang , Guo Yuedong , Huang Yuhui 
Published: November 2021

AbstractUnderstanding the shifts in competitive ability and its driving forces is key to predict the future of plant invasion. Changes in the competition environment and soil biota are two selective forces that impose remarkable influences on competitive ability. By far, evidence of the interactive effects of competition environment and soil biota on competitive ability of invasive species is rare. Here, we investigated their interactive effects using an invasive perennial vine, Mikania micrantha. The competitive performance of seven M. micrantha populations varying in their conspecific and heterospecific abundance were monitored in a greenhouse experiment, by manipulating soil biota (live and sterilized) and competition conditions (competition‐free, intraspecific, and interspecific competition). Our results showed that with increasing conspecific abundance and decreasing heterospecific abundance, (1) M. micrantha increased intraspecific competition tolerance and intra‐ vs. interspecific competitive ability but decreased interspecific competition tolerance; (2) M. micrantha increased tolerance of the negative soil biota effect; and (3) interspecific competition tolerance of M. micrantha was increasingly suppressed by the presence of soil biota, but intraspecific competition tolerance was less affected. These results highlight the importance of the soil biota effect on the evolution of competitive ability during the invasion process. To better control M. micrantha invasion, our results imply that introduction of competition‐tolerant native plants that align with conservation priorities may be effective where M. micrantha populations are long‐established and inferior in inter‐ vs. intraspecific competitive ability, whereas eradication may be effective where populations are newly invaded and fast‐growing.
Left ventricular epicardial pacing achieved hyper‐responsiveness in young children with dilated cardiomyopathy with left bundle branch block
Authors: Sun Sijuan , Guo Xiaofeng , Chen Yiwei , Shen Jie , Zhu Diqi , Zhang Zhifang , Fu Lijun , Ji Wei , Li Fen 
Published: November 2021

AbstractAimsThe management of heart failure (HF) in young children is challenging. The present study aimed to clarify the effect of left univentricular epicardial pacing on dilated cardiomyopathy with left bundle branch block (LBBB) in children.Methods and resultsA total of five cases (30.86 ± 16.39 months, three female) of children weighing 5.8–15 kg with dilated cardiomyopathy and LBBB were included in this study. LBBB in one child occurred after device closure of peri‐membranous ventricular septal defects, and the remaining four were idiopathically discovered early after birth. Before implantation, all children suffered from refractory HF and cardiac dilatation; the left ventricular ejection fraction was 33.48 ± 5.84% with Ross Heart Failure Classification III–IV. Electrical and mechanical dyssynchrony were observed in all children with QRS duration >140 ms and prolonged septal‐to‐left posterior wall motion delay. Left univentricular epicardial pacing was successfully implanted via left axillary minithoracotomy in the five children. Sensed atrioventricular delays (83 ± 15 ms) were optimized by velocity time integral of aortic blood flow before discharge. During the follow‐up period (10.8 ± 2.68 months), the dilated failing heart was reversed significantly in terms of decreased left ventricular dimension (55.62 ± 3.46 vs. 38.94 ± 3.69 mm, P = 0.005), while the left ventricular ejection fraction improved to 60.18 ± 8.78% (P = 0.006).ConclusionsIn young children with low body weight, if HF is caused by or related to LBBB, left ventricular epicardial pacing still has an excellent effect.
Notch1 deficiency alters the migratory behavior of developing T cells and calcium signaling in the thymus of medaka
Authors: Aghaallaei Narges , Inoue Daigo , Hasel de Carvalho Eva , Dick Advaita M. , Wittbrodt Joachim , Leptin Maria , Bajoghli Baubak 
Published: November 2021

AbstractThe differentiation of T cells from lymphoid progenitors in the thymus follows sequential developmental stages that constantly require interaction with thymic epithelial cells. Several distinct aspects of early T cell development depend on the activation of Notch receptors on thymocytes, while the selection of thymocytes at later stages are believed to be Notch independent. Using reverse genetic approaches and whole‐thymus live imaging in an in vivo teleost model, the medaka, we report that Notch1 signals is required for proliferation and specification of developing T cells as well as involved in their selection in the thymus. We reveal that Notch1 controls the migratory behavior of thymocytes through controlling the chemokine receptor Ccr9b and thereby influence the T cell receptor (TCR) activation. Hence, we propose that, in lower vertebrates, the function of Notch signaling extends to all stages of T cell development, except when thymocytes undergo TCRβ rearrangement.
Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia
Authors: Sala Arianna , Malpetti Maura , Farsad Mohsen , Lubian Francesca , Magnani Giuseppe , Frasca Polara Giulia , Epiney Jean‐Benoit , Abutalebi Jubin , Assal Frédéric , Garibotto Valentina , Perani Daniela 
Published: November 2021

AbstractLifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. Here, we aim to study the effects of lifelong bilingualism as a dichotomous and continuous phenomenon, on brain metabolism and connectivity in individuals with Alzheimer's dementia. Ninety‐eight patients with Alzheimer's dementia (56 monolinguals; 42 bilinguals) from three centers entered the study. All underwent an [18F]‐fluorodeoxyglucose positron emission tomography (PET) imaging session. A language background questionnaire measured the level of language use for conversation and reading. Severity of brain hypometabolism and strength of connectivity of the major neurocognitive networks was compared across monolingual and bilingual individuals, and tested against the frequency of second language life‐long usage. Age, years of education, and MMSE score were included in all above mentioned analyses as nuisance covariates. Cerebral hypometabolism was more severe in bilingual compared to monolingual patients; severity of hypometabolism positively correlated with the degree of second language use. The metabolic connectivity analyses showed increased connectivity in the executive, language, and anterior default mode networks in bilingual compared to monolingual patients. The change in neuronal connectivity was stronger in subjects with higher second language use. All effects were most pronounced in the left cerebral hemisphere. The neuroprotective effects of lifelong bilingualism act both against neurodegenerative processes and through the modulation of brain networks connectivity. These findings highlight the relevance of lifelong bilingualism in brain reserve and compensation, supporting bilingual education and social interventions aimed at usage, and maintenance of two or more languages, including dialects, especially crucial in the elderly people.