bluuebunny/crossref_metadata_2025_split huggingface dataset:
Montelukast alleviates inflammation in experimental autoimmune encephalomyelitis by altering Th17 differentiation in a mouse model
Authors: Han Bing , Zhang Yan‐Yan , Ye Ze‐Qing , Xiao Yun , Rasouli Javad , Wu Wen‐Cheng , Ye Su‐Min , Guo Xin‐Yue , Zhu Lin , Rostami Abdolmohamad , Wang Li‐Bin , Zhang Yuan , Li Xing 
Published: January 2021

SummaryMontelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotriene receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through disrupting chemotaxis of infiltrating T cells. However, the role of CysLTR1 in the pathogenesis of MS is not well understood. Here, we show that MS patients had higher expression of CysLTR1 in the circulation and central nervous system (CNS). The majority of CD4+ T cells expressed CysLTR1 in MS lesions. Among T‐cell subsets, Th17 cells had the highest expression of CysLTR1, and blocking CysLTR1 signalling abrogated their development in vitro. Inhibition of CysLTR1 by montelukast suppressed EAE development in both a prophylactic and therapeutic manner and inhibited myelin loss in EAE mice. Similarly, the in vivo results showed that montelukast inhibited Th17 response in EAE mice and that Th17 cells treated with montelukast had reduced encephalitogenic in adoptive EAE. Our findings strongly suggest that targeting Th17 response by inhibiting CysLTR1 signalling could be a promising therapeutic strategy for the treatment of MS and CNS inflammatory diseases.
Effect of an intensive intervention on the increase of physical activity and the decrease of sedentary lifestyle in inactive postmenopausal
Authors: Alonso‐Domínguez Rosario , Sánchez‐Aguadero Natalia , Llamas‐Ramos Inés , Lugones‐Sánchez Cristina , González‐Sánchez Susana , Gómez‐Marcos Manuel A. , García‐Ortiz Luis ,   Ewomen Investigators
Published: January 2021

AbstractBackgroundDuring the transition to menopause, women experience different psychological, hormonal, and physical alterations that can affect their health. Physical activity is considered an important strategy in the prevention and control of such changes.AimTo evaluate the short‐term effect of an intensive intervention, based on a combined exercise programme using a Smartband, on the increase of physical activity and the decrease of sedentary lifestyle in postmenopausal and inactive women.DesignRandomized clinical trial with two parallel groups.MethodsIn total, 100 postmenopausal and inactive women aged 45–70 years will be randomized to a control group or an intervention group. Both groups will be given a standardized advice about physical activity. The intervention group will carry out a supervised 12‐week programme of aerobic and muscle strengthening exercise; moreover, the women in this group will receive a Smartband to assist them in the intervention. The main result will be the increase of physical activity and the decrease of sedentary lifestyle, measured with an accelerometer for 1 week. This programme will be conducted by a nurse and a physiotherapist of the health centre. The study was approved by the Drug Research Ethics Committee of the Salamanca Health Service on 15 February 2019. The project was funded by the Autonomous Government of Castile and Leon and by the Carlos III Health Institute.DiscussionPhysical activity is an important strategy to consider when addressing the changes caused by menopause, although the current evidence shows that further studies should be carried out with longer intervention periods and new technologies.ImpactThis study will allow determining the effectiveness of the intensive intervention based on a combined programme of physical activity using a Smartband in postmenopausal and inactive women.Trials RegistrationClinicalTrials.gov with identifying code NCT03872258.
Co‐designing diagnosis: Towards a responsible integration of Machine Learning decision‐support systems in medical diagnostics
Authors: Kudina Olya , de Boer Bas 
Published: January 2021

AbstractRationaleThis paper aims to show how the focus on eradicating bias from Machine Learning decision‐support systems in medical diagnosis diverts attention from the hermeneutic nature of medical decision‐making and the productive role of bias. We want to show how an introduction of Machine Learning systems alters the diagnostic process. Reviewing the negative conception of bias and incorporating the mediating role of Machine Learning systems in the medical diagnosis are essential for an encompassing, critical and informed medical decision‐making.MethodsThis paper presents a philosophical analysis, employing the conceptual frameworks of hermeneutics and technological mediation, while drawing on the case of Machine Learning algorithms assisting doctors in diagnosis. This paper unravels the non‐neutral role of algorithms in the doctor's decision‐making and points to the dialogical nature of interaction not only with the patients but also with the technologies that co‐shape the diagnosis.FindingsFollowing the hermeneutical model of medical diagnosis, we review the notion of bias to show how it is an inalienable and productive part of diagnosis. We show how Machine Learning biases join the human ones to actively shape the diagnostic process, simultaneously expanding and narrowing medical attention, highlighting certain aspects, while disclosing others, thus mediating medical perceptions and actions. Based on that, we demonstrate how doctors can take Machine Learning systems on board for an enhanced medical diagnosis, while being aware of their non‐neutral role.ConclusionsWe show that Machine Learning systems join doctors and patients in co‐designing a triad of medical diagnosis. We highlight that it is imperative to examine the hermeneutic role of the Machine Learning systems. Additionally, we suggest including not only the patient, but also colleagues to ensure an encompassing diagnostic process, to respect its inherently hermeneutic nature and to work productively with the existing human and machine biases.
Nanotechnology for modern medicine: next step towards clinical translation
Authors: Sindhwani Shrey , Chan Warren C. W. 
Published: January 2021

AbstractThe field of nanotechnology has been a significant research focus in the last thirty years. This emphasis is due to the unique optical, electrical, magnetic, chemical and biological properties of materials approximately ten thousand times smaller than the diameter of a hair strand. Researchers have developed methods to synthesize and characterize large libraries of nanomaterials and have demonstrated their preclinical utility. We have entered a new phase of nanomedicine development, where the focus is to translate these technologies to benefit patients. This review article provides an overview of nanomedicine's unique properties, the current state of the field, and discusses the challenge of clinical translation. Finally, we discuss the need to build and strengthen partnerships between engineers and clinicians to create a feedback loop between the bench and bedside. This partnership will guide fundamental studies on the nanoparticle–biological interactions, address clinical challenges and change the development and evaluation of new drug delivery systems, sensors, imaging agents and therapeutic systems.
Host immune responses in dermatophytes infection
Authors: Celestrino Giovanna Azevedo , Verrinder Veasey John , Benard Gil , Sousa Maria Glória Teixeira 
Published: January 2021

AbstractDermatophytosis is a skin infection caused by keratinophilic, filamentous fungi. These are highly prevalent, common mycoses, affecting approximately 20% of the population. These fungi invade the stratum corneum, and other keratinised tissues, like nails and hair, where they grow by secreting enzymes and degrading keratin to obtain nutrients. Clinical presentation is variable and may depend on many factors, such as the infection site, the host's immunity and the dermatophyte's virulence. Generally, patients with acute superficial dermatophytosis mount cell‐mediated immune responses. However, those suffering from chronic or recurrent infections are unable to develop this response, for reasons yet unknown. Several reports have described severe and occasionally life‐threatening invasive diseases (deep dermatophytosis) associated with genetic mutations in the innate immunity‐associated molecule CARD9, displaying the need to better understand its immune response. These dermatoses have substantial clinical consequences, producing chronic and difficult to treat skin lesions. They also lead to a decline in the patient's quality of life and impact their self‐esteem. This review summarises findings on the immune response against dermatophytes.
Environmental and developmental factors driving xylem anatomy and micro‐density in black spruce
Authors: Buttò Valentina , Rozenberg Philippe , Deslauriers Annie , Rossi Sergio , Morin Hubert 
Published: January 2021

Summary

Wood density is the product of carbon allocation for structural growth and reflects the trade‐off between mechanical support and water conductivity. We tested a conceptual framework based on the assumption that micro‐density depends on direct and indirect relationships with endogenous and exogenous factors.

The dynamics of wood formation, including timings and rates of cell division, cell enlargement, and secondary wall deposition, were assessed from microcores collected weekly between 2002 and 2016 from five black spruce stands located along a latitudinal gradient in Quebec, Canada. Cell anatomy and micro‐density were recorded by anatomical analyses and X‐ray measurements.

Our structural equation model explained 80% of micro‐density variation within the tree‐ring with direct effects of wall thickness (σ = 0.61), cell diameter (σ = −0.51), and photoperiod (σ = −0.26). Wood formation dynamics had an indirect effect on micro‐density. Micro‐density increased under longer periods of cell‐wall deposition and shorter durations of enlargement.

Our results fill a critical gap in understanding the relationships underlying micro‐density variation in conifers. We demonstrated that short‐term responses to environmental variations could be overridden by plastic responses that modulate cell differentiation. Our results point to wood formation dynamics as a reliable predictor of carbon allocation in trees.
Wrist Reconstruction after En bloc Resection of Bone Tumors of the Distal Radius
Authors: Liu Weijian , Wang Baichuan , Zhang Shuo , Li Yubin , Hu Binwu , Shao Zengwu 
Published: January 2021

Wrist reconstruction after en bloc resection of bone tumors of the distal radius has been a great challenge. Although many techniques have been used for the reconstruction of long bone defects following en bloc resection of the distal radius, the optimal reconstruction method remains controversial. This is the first review to systematically describe various reconstruction techniques. We not only discuss the indications, functional outcomes, and complications of these reconstruction techniques but also review the technical refinement strategies for improving the stability of the wrist joint.En bloc resection should be performed for Campanacci grade III giant cell tumors (GCT) as well as malignant tumors of the distal radius. However, wrist reconstruction after en bloc resection of the distal radius represents a great challenge. Although several surgical techniques, either achieving a stable wrist by arthrodesis or reconstructing a flexible wrist by arthroplasty, have been reported, the optimal reconstruction procedure remains controversial. The purpose of this review was to investigate which reconstruction methods might be the best option by analyzing the indications, techniques, limitations, and problems of different reconstruction methods. With the advancement of imaging, surgical techniques and materials, some reconstruction techniques have been further refined. Each of the techniques discussed in this review has its advantages and disadvantages. Wrist arthrodesis seems to be preferred over wrist arthroplasty in terms of grip strength and long‐term complications, while wrist arthroplasty seems to be superior to wrist arthrodesis in terms of wrist motion. All things considered, wrist arthroplasty with a vascularized fibular head autograft might be a good option because of better wrist function, acceptable grip strength, and a relatively lower complication rate. Moreover, wrist arthrodesis is still an option if the fibular head autograft reconstruction fails. Orthopaedic oncologists should familiarize themselves with the characteristics of each technique to select the most appropriate reconstruction method depending on each patient's situation.
Systemic Risk: The Threat to Societal Diversity and Coherence
Authors: Renn Ortwin , Lucas Klaus 
Published: January 2021

AbstractInsights from complexity science can be applied to the analysis of social processes in heterogeneous societies. Many features that characterize and influence complex structures in nearly every domain of nature, technology, and society can be derived from simple modeling processes in physics and chemistry. If one applies these features to the structure of social risks, a number of insights are gained that can be subject to further empirical analysis. In particular, they add—to the well‐known steering mechanisms of hierarchy, competition, and cooperation—the contribution of self‐organization, the effect of which is underestimated in almost all theories of social science. But in view of the crises facing modern democracy, such as migration and populism, it is precisely this mechanism of dynamic structure generation that is decisive for an effective and fair risk governance. In this article, we analyze the threat to societal diversity and coherence on the basis of complexity science.
Feldspar recycling across magma mush bodies during the voluminous Half Dome and Cathedral Peak stages of the Tuolumne intrusive complex, Yosemite National Park, California, USA
Authors: Oppenheim Louis F. , Memeti Valbone , Barnes Calvin G. , Chambers Melissa , Krause Joachim , Esposito Rosario 
Published: January 2021

Abstract
Incremental pluton growth can produce sheeted complexes with no magma-magma interaction or large, dynamic magma bodies communicating via crystal and melt exchanges, depending on pulse size and frequency of intrusions. Determining the degree and spatial extent of crystal-melt exchange along and away from plutonic contacts at or near the emplacement level, such as in the large, long-lived Tuolumne intrusive complex (TIC) in California, sheds light onto the process and evolution of incremental growth.
This study used field mapping and petrographic and geochemical analysis of plagioclase and K-feldspar populations in the equigranular Half Dome (eHD), porphyritic Half Dome (pHD), and Cathedral Peak (CP) Granodiorites of the southeastern section of the TIC to determine the presence and/or extent of feldspar recycling at interunit contacts. Our results suggest that contacts between major units are predominantly ∼400-m- to 3-km-thick gradational zones. K-feldspar is compositionally distinct in eHD and neighboring gradational zones and shows no evidence of mixing. K-feldspar in a gradational zone between pHD and CP shows evidence of mixing between the two. Plagioclase in eHD and CP display distinct ranges of anorthite content, Sr, and light rare earth element abundances; both populations are observed in pHD. Major oxide and trace element calculations of melts in equilibrium with plagioclase cores indicate that the melts were more silicic, less calcic, and lower in Sr and Rb than corresponding analyzed whole-rock samples. These results suggest that the magmas also underwent plagioclase and biotite accumulation. The presence of two plagioclase populations in pHD is consistent with eHD and CP hybridizing to form pHD in an increasingly maturing and exchanging TIC magmatic system during the eHD-pHD-CP stages but before groundmass and small K-feldspar phenocrysts crystallized.
Transport time after combat-related injury and patient-reported outcomes among US service members
Authors: Hawari Raneem J , McCabe C T , Dougherty A L , Eskridge S L , Watrous J R , Sazon J , Galarneau M R 
Published: January 2021

IntroductionThe ‘golden hour’ is a universal paradigm that suggests trauma patients have lower morbidity and mortality when provided with medical care within 1 hour after injury. The objective of this study was to examine whether transport time from point of injury to a military treatment facility (MTF) in-theatre was associated with patient-reported outcomes, such as post-traumatic stress disorder (PTSD), depression and quality of life (QOL), among US service members with combat-related injury.MethodsParticipants were injured between March 2003 and March 2016 and completed standardised assessments of PTSD, depression and QOL for theWounded Warrior Recovery Project (WWRP) between January 2013 and November 2017. Multivariable regressions were used to assess the relationship between transport time (≤1 hour or >1 hour from injury to MTF) and positive screens for PTSD and depression, and QOL, respectively.Overall, 45.6% of participants (n=879) arrived at an MTF within 1 hour postinjury. About 8 years passed between when participants were injured on deployment and when they completed their first WWRP assessment. Approximately 48% of participants screened positive for PTSD and 51.3% for depression, with a mean QOL score of 0.513 (SD=0.150). After adjusting for covariates, transport time was not significantly associated with PTSD (OR 1.04, 95% CI 0.79 to 1.38; p=0.77), depression (OR 0.92, 95% CI 0.69 to 1.21; p=0.55) or QOL (β=0.009; p=0.38).ConclusionTransport time was not associated with patient-reported outcomes among US service members with combat-related injury. These findings are important as we seek to understand how combat casualties may be affected by extended medical evacuation or transport times anticipated in future expeditionary operations.
Cohort profile: the St Vincent’s Melbourne Arthroplasty Outcomes (SMART) Registry, a pragmatic prospective database defining outcomes in total hip and knee replacement patients
Authors: Gould Daniel , Thuraisingam Sharmala , Shadbolt Cade , Knight Josh , Young Jesse , Schilling Chris , Choong Peter F , Dowsey Michelle M 
Published: January 2021

PurposeThe St Vincent’s Melbourne Arthroplasty Outcomes (SMART) Registry is an institutional clinical registry housed at a tertiary referral hospital in Australia. The SMART Registry is a pragmatic prospective database, which was established to capture a broad range of longitudinal clinical and patient-reported outcome data to facilitate collaborative research that will improve policy and practice relevant to arthroplasty surgery for people with advanced arthritis of the hip or knee. The purpose of this cohort profile paper is to describe the rationale for the SMART Registry’s creation, its methods, baseline data and future plans for the Registry. A full compilation of the data is provided as a reference point for future collaborators.ParticipantsThe SMART Registry cohort comprises over 13 000 consecutive arthroplasty procedures in more than 10 000 patients who underwent their procedure at St Vincent’s Hospital Melbourne, since January 1998. Participant recruitment, data collection and follow-up is ongoing and currently includes up to 20 years follow-up data.Findings to dateSMART Registry data are used for clinical audit and feedback, as well as for a broad range of research including epidemiological studies, predictive statistical modelling and health economic evaluations. At the time of writing, there were 46 publications from SMART Registry data, with contributions from more than 67 coauthors.Future plansWith the recent linking of the SMART Registry with Medicare Benefits Schedule and Pharmaceutical Benefits Scheme data through the Australian Institute of Health and Welfare, research into prescribing patterns and health system utilisation is currently underway. The SMART Registry is also being updated with the Clavien-Dindo classification of surgical complications.
Effect of screening young men for Chlamydia trachomatis on the rates among women: a network modelling study for high-prevalence communities
Authors: Qu Zhuolin , Azizi Asma , Schmidt Norine , Craig-Kuhn Megan Clare , Stoecker Charles , Hyman James Mac , Kissinger Patricia J 
Published: January 2021

ObjectiveChlamydia trachomatis (Ct) is the most commonly reported sexually transmitted infection in the USA and causes important reproductive morbidity in women. The Centers for Disease Control and Prevention recommend routine screening of sexually active women under age 25 but not among men. Despite three decades of screening women, chlamydia prevalence in women remains high. Untested and untreated men can serve as a reservoir of infection in women, and male-screening based intervention can be an effective strategy to reduce infection in women. We assessed the impact of screening men on the Ct prevalence in women.DesignWe created an individual-based network model to simulate a realistic chlamydia epidemic on sexual contact networks for a synthetic population (n=5000). The model is calibrated to the ongoing routine screening among African American (AA) women in the USA and detailed a male-screening programme, Check It, that bundles best practices for Ct control. We used sensitivity analysis to quantify the relative importance of each intervention component.SettingCommunity-based venues in New Orleans, Louisiana, USA.ParticipantsHeterosexual AA men, aged 15 to 24, who had sex with women in the past 2 months.InterventionVenue-based screening, expedited index treatment, expedited partner treatment and rescreening.ResultsWe estimate that by annually screening 7.5% of the AA male population in the age-range, the chlamydia prevalence would be reduced relatively by 8.1% (95% CI 5.9% to 10.4%) in AA women and 8.8% (95% CI 6.9% to 10.8%) in AA men. Each man screened could prevent 0.062 (95% CI 0.030 to 0.094) cases in men and 0.204 (95% CI 0.143 to 0.267) cases in women. The model suggested the importance of intervention components ranked from high to low as venue-based screening, expedited index treatment, expedited partner treatment and rescreening.ConclusionThe findings indicated that male-screening has the potential to substantially reduce the prevalence among women in high-prevalence communities.