bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank
Authors: Young William J. , Warren Helen R. , Mook-Kanamori Dennis O. , Ramírez Julia , van Duijvenboden Stefan , Orini Michele , Tinker Andrew , van Heemst Diana , Lambiase Pier D. , Jukema J. Wouter , Munroe Patricia B. , Noordam Raymond 
Published: April 2021

Background:
ECG markers of ventricular depolarization and repolarization are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT and JT intervals in the general population. Here, we investigate whether serum calcium is a causal risk factor for changes in ECG measures using Mendelian randomization (MR).

Methods:
Independent lead variants from a newly performed genome-wide association study for serum calcium in >300 000 European-ancestry participants from UK Biobank were used as instrumental variables. Two-sample MR analyses were performed to approximate the causal effect of serum calcium on QT, JT, and QRS intervals using an inverse-weighted method in 76 226 participants not contributing to the serum calcium genome-wide association study. Sensitivity analyses including MR-Egger, weighted-median estimator, and MR pleiotropy residual sum and outlier were performed to test for the presence of horizontal pleiotropy.

Results:
Two hundred five independent lead calcium-associated variants were used as instrumental variables for MR. A decrease of 0.1 mmol/L serum calcium was associated with longer QT (3.01 ms [95% CI, 2.03 to 3.99]) and JT (2.89 ms [1.91 to 3.87]) intervals. A weak association was observed for QRS duration (secondary analyses only). Results were concordant in all sensitivity analyses.

Conclusions:
These analyses support a causal effect of serum calcium levels on ventricular repolarization, in a middle-aged population of European-ancestry where serum calcium concentrations are likely stable and chronic. Modulation of calcium concentration may, therefore, directly influence cardiovascular disease risk.
The Self-Constrained Hand-to-Mouth
Authors: Gelman Michael 
Published: April 2021

Abstract
Many studies have shown that consumption responds to the arrival of predictable income (excess sensitivity). This paper uses a buffer stock model of consumption to understand what causes excess sensitivity and to test which parameterization is consistent with empirical excess sensitivity estimates. Using high-frequency granular data from a personal finance app, I find that while liquidity constraints are a proximate cause, preferences are the ultimate cause of excess sensitivity. Furthermore, it finds that for feasible parameters, a quasi-hyperbolic version of the model is more consistent with the level of excess sensitivity relative to a standard exponential model.
Revisiting the Chorzów Factory Standard of Reparation – Its Relevance in Contemporary International Law and Practice
Authors: Torres Felix E. 
Published: April 2021

Abstract
The Chorzów Factory standard of reparation has been consolidated in the mind-set of international actors since the International Law Commission’s Articles on State Responsibility were adopted in 2001. This article analyses to what extent the recent case law of the International Court of Justice and other international practice concerning injury to aliens and property rights, especially expropriations, reflect the Chorzów Factory standard. It does so by considering whether ‘full reparation’ is the central issue in international disputes that involve state responsibility, if restitutio in integrum prevails over other forms of redress, and if the amount of compensation is established in light of the principle of ‘full reparation’. The interaction between the secondary rules of state responsibility and the primary rules of expropriation will be considered in investor-state disputes. In addressing these questions, the role that adjudicating bodies understand they play in international law and the interests pursued by stakeholders – states and private investors – are examined.
Family Unity and International Protection – EU Regulation and its Compatibility with the echr
Authors: Milios Georgios 
Published: April 2021

Abstract
The present article deals with the issue of family unity in the field of international protection, with a special focus on the European Union (EU) rules and their compatibility with the European Convention on Human Rights (echr) standards. In particular, the scope of the article is limited to family transfers of seekers of international protection under the Dublin system and to family reunification procedures for refugees, and beneficiaries of subsidiary protection. After examining the legal framework at EU and domestic level, the present study focuses on two rather controversial issues, from a human rights perspective: on one side, the regulation of the right to family reunification for beneficiaries of subsidiary protection and, on the other side, the different treatment between pre- and post-flight families in the field of international protection. The article concludes that the current rules regarding these two issues are not compatible with Article 8 of the echr taken together with Article 14 of the echr, and with Article 8 of the echr taken alone. It suggests that while the EU and domestic legislature remains inactive in order to correct these inequalities, the non-discrimination clauses may become directly applicable.
Hydraulic function and conduit structure in the xylem of five oak species
Authors: Percolla Marta I. , Fickle Jaycie C. , Rodríguez-Zaccaro F. Daniela , Pratt R. Brandon , Jacobsen Anna L. 
Published: April 2021

Abstract
Many plant lineages, including oaks (Quercus spp.), have both vessels and tracheids as hydraulically conductive cells within their xylem. The structure of these co-occurring conduit types and their contribution to plant hydraulic function have been relatively little studied. We hypothesized that vasicentric tracheids contribute to hydraulic function under conditions of low water availability. We predicted that within a species, oaks growing at drier and warmer low elevation sites would have more tracheids and be more embolism resistant compared to those growing at moister and colder higher elevation sites. We also predicted that across species, lower elevation oaks would have increased tracheid abundance within their xylem. Five oak species differed in many xylem traits, including vessel diameter and length, tracheid size and abundance, embolism resistance, and hydraulic conductivity. Tracheids were most abundant in the xylem of the highest elevation species at sites that receive winter snow and freezing temperatures. Vessels were relatively vulnerable to embolism as confirmed with multiple methods, including centrifuge vulnerability curves, micro-CT scans of native stem samples, and single vessel air injection. Theoretical conductivity calculations indicated that tracheids account for 5.7–15.5% of conductivity in hydrated stems, with tracheids likely increasing in importance as large diameter vulnerable vessels embolize. The occurrence of both vessels and vasicentric tracheids in the xylem of oaks may enable them to function within highly seasonal climates. Tracheids, though often overlooked, may be particularly important in maintaining conductivity throughout much of the year when water potentials decline from seasonal maximums and following freeze-thaw events.
Scottish rheumatology sonography course: five-year experience of delivering a mentorship-model rheumatology ultrasound training programme accredited by the consortium for the accreditation of sonographic education
Authors: Ciechomska Anna , McKay Neil D , Newcombe Lisa , Brandon Mhairi , Youssef Hazem , Platt Philip , Dale James , Dickson Diane M 
Published: April 2021

Background and aims Ultrasound training for rheumatology practice in the UK is variable. Currently, there is no agreed minimum standard for training in ultrasound applied to rheumatology patient management. We present our experiences of implementing a competency driven ultrasound training, focused on hands and feet. Methods and results The Rheumatology Sonography Course (RSC) was developed by the Scottish Rheumatology Ultrasound Group in collaboration with Glasgow Caledonian University. The RSC is delivered via a blended learning approach and includes training workshops, mentorship and clinical competency assessments. Mentors are supported and developed within their role. 31 trainees have enrolled on the course between 2014 and 2019. To date, 22 (71%) have completed. Change of job role was the main factor leading to non-completion. Thirteen mentors have supported the training and assessment of RSC trainees. All trainees reported positively that ultrasound training via the RSC model fulfilled their learning needs. Conclusion The RSC is a feasible ultrasound training model for rheumatology practitioners. Whilst it provides a robust training framework, mentorship fees and university overheads increase the cost. The RSC provides motivation to mentors to train external trainees and supports the development of new ultrasound-based rheumatology services.
Treatment Strategies and Outcomes for Osteochondritis Dissecans of the Capitellum
Authors: Sayani Junaid , Plotkin Tobias , Burchette Daniel Timothy , Phadnis Joideep 
Published: April 2021

Background: The optimum management of osteochondritis dissecans (OCD) of the capitellum is a widely debated subject. Purpose: To better understand the efficacy of different surgical modalities and nonoperative treatment of OCD as assessed by radiological and clinical outcomes and return to sports. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of all treatment studies published between January 1975 and June 2020 was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A total of 76 clinical studies, including 1463 patients, were suitable for inclusion. Aggregate analysis and subgroup analysis of individual patient data were performed to compare the functional and radiographic outcomes between the various nonoperative and surgical treatment options for capitellar OCD. A unified grading system (UGS; grades 1-4) was developed from existing validated classification systems to allow a comparison of patients with similar-grade OCD lesions in different studies according to their treatment. Patient-level data were available for 352 patients. The primary outcome measures of interest were patient-reported functional outcome, range of motion (ROM), and return to sports after treatment. The influences of the capitellar physeal status, location of the lesion, and type of sports participation were also assessed. Each outcome measure was evaluated according to the grade of OCD and treatment method (debridement/microfracture, fragment fixation, osteochondral autograft transplantation [OATS], or nonoperative treatment). Results: No studies reported elbow scores or ROM for nonoperatively treated patients. All surgical modalities resulted in significantly increased postoperative ROM and elbow scores for stable (UGS grades 1 and 2) and unstable lesions (UGS grades 3 and 4). There was no significant difference in the magnitude of improvement or overall scores according to the type of surgery for stable or unstable lesions. Return to sports was superior with nonoperative treatment for stable lesions, whereas surgical treatment was superior for unstable lesions. Patients with an open capitellar physis had superior ROM for stable and unstable lesions, but there was no correlation with lesion location and the outcomes of OATS versus fragment fixation for high-grade lesions. Conclusion: Nonoperative treatment was similar in outcomes to surgical treatment for low-grade lesions, whereas surgical treatment was superior for higher grade lesions. There is currently insufficient evidence to support complex reconstructive techniques for high-grade lesions compared with microfracture/debridement alone.
Treatment of Severe Hypertriglyceridemia With Insulin Infusions in Severe COVID-19: A Case Series
Authors: Thomas Caitlin M. , Vicent Martie , Moore Shawn , Ali Fahd , Wooten Leslie , Louzon Patricia R. 
Published: April 2021

Purpose: Rapid onset of severe hypertriglyceridemia was quickly recognized in critical COVID-19 patients. Associated causes have been due to secondary hemophagocytic lymphohystiocytosis (HLH) syndrome, medication-induced, or acute liver failure. Statins, omega-3 polyunsaturated acids, niacin, and fibrates are common oral lipid lowering therapy options in patients at risk for hypertriglyceridemia. The severity of hypertriglyceridemia in COVID-19 patients with triglyceride values reaching greater than 1,000 mg/dL put them at a heightened risk of pancreatitis and therefore an essential need to acutely lower their levels. We present a case series of 5 patients who achieved rapid triglyceride lowering through continuous insulin infusion therapy. Methods: A retrospective chart review of 48 critical COVID-19 patients who were admitted from March 22 to April 15, 2020 was conducted. Inclusion criteria consisted of mechanical ventilation and continuous insulin infusion to treat severe hypertriglyceridemia resulting with 5 eligible patients in this case report. Results and Conclusion: In addition to standard oral lipid lowering therapies, continuous insulin infusion successfully treated severe hypertriglyceridemia in critically ill COVID-19 patients. None of the patients experienced pancreatitis or hypoglycemia necessitating cessation of insulin. Further studies are needed to show the optimum dose and duration of insulin infusion as monotherapy and in combination with oral therapies.
Skills for Future Work (H2030): Multigroup Analysis in Professional and Baccalaureate Training
Authors: Chacón-Cuberos Ramón , Expósito-López Jorge , de la Guardia José Javier Romero-Díaz , Olmedo-Moreno Eva María 
Published: April 2021

Purpose: This study sought to validate the Skills for Future Work Scale for its use with professional/vocational training (PT) and baccalaureate students. Methods: A total of 1,159 students were recruited. Structural equation analysis was performed using IBM Amos Graphics®. Results: Excellent fit indices were obtained, forming a final scale composed of nine indicators and two factors. The first dimension was associated with cognitive skills and adaptability, grouping together the skills of finding meaning, adaptable thinking, and understanding management. The second dimension comprises collaborative skills, as social intelligence and virtual collaboration. Discussion: Collaboration skills were more developed within those undertaking PT, while baccalaureate students had more strongly developed mastery over new media. This scale allows to know effectively the development of the work skills set by the European Union in the 2030 horizon. These findings contribute interesting data regarding the development of training strategies to support insertion into the job market.
Black Youth and African-Centered Interventions: A Systematic Review
Authors: Lateef Husain , Amoako Emmanuel O. , Nartey Portia , Tan Jia , Joe Sean 
Published: April 2021

Purpose: This review discusses the effectiveness of African-centered interventions (ACIs) with Black youth. Methods: The authors conducted a comprehensive search of ACIs using electronic bibliographic databases to identify studies completed in the United States and reported in peer-reviewed journals. A total of 10 studies were identified that met the full inclusion criteria of the review. Results: Collectively, we found that ACIs are associated with positive outcomes in Black youths’ academic achievement, self-concept, cultural identity, and behaviors. However, there was a noteworthy amount of heterogeneity in studies’ methodological rigor. Discussion: The small number of studies identified support the need for additional research with high standards of methodological rigor to further determine the effectiveness of using ACIs over universal interventions with Black youth.
Three-Dimensional Dynamic Analysis of the Reproducibility of Verbal and Nonverbal Facial Expressions
Authors: Qiu Tiancheng , Xue Zulin , Wu Ling , Yang Rong , Liu Xiaojing , Wang Xing , Li Zili 
Published: April 2021

Objective: The aim of this study is to compare the short- and long-term reproducibility of verbal and nonverbal facial expressions of normal people using dynamic 3-dimensional (3-D) imaging. Design: Prospective, cross-sectional, controlled study. Setting: Peking University School and Hospital of Stomatology, Beijing, China. Patients and Participants: Twenty-seven participants, 12 males and 15 females, were recruited for this study. Methods: A 3-D dynamic system was applied to capture the process of 4 nonverbal facial expressions (smile lips closed, smile lips open, lip purse, cheek puff) and 2 verbal facial expressions (/i:/, /u:/) at an initial time point, 15 minutes later, and 1 week later. Key frames were selected from each expression recording sequence. Main Outcome Measures: The root mean square (RMS) between each key frame and its corresponding frame at rest was calculated. ΔRMS reflected the difference of the same key frames between the different sessions of the same expression of the same participant. The reproducibility of different facial expressions at different time intervals were analyzed. Results: There was no significant difference in verbal and nonverbal expression repeatability during a 15-minute interval, except for cheek puff motion. Following a 1-week interval, verbal expression repeatability was superior to that of nonverbal expressions ( P < .01). Compared with nonverbal expressions, the repeatability of verbal expressions did not obviously decrease with the increase in recording interval. Conclusions: Dynamic 3-D imaging is a useful technique for facial expression analysis. Verbal expressions showed greater reproducibility than nonverbal expressions.
Long-Term Effects of Nasoalveolar Molding in Patients With Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis
Authors: Padovano William M. , Skolnick Gary B. , Naidoo Sybill D. , Snyder-Warwick Alison K. , Patel Kamlesh B. 
Published: April 2021

Objective: The aim of this systematic review and meta-analysis was to investigate long-term treatment effects of nasoalveolar molding (NAM) in patients with unilateral cleft lip and palate (UCLP). Design: Included manuscripts met the following criteria: (1) involved patients with UCLP who received NAM; (2) included comparison group(s) who either received non-NAM passive presurgical infant orthopedic appliances (PSIO) or who did not receive any PSIO; (3) reported at least one objective or validated measure of nasolabial, craniofacial, or palatal form; and (4) had patient follow-up beyond 4 years of age. Results: A total of 12 studies were included in this review. Meta-analyses were possible for Asher-McDade parameters and cephalometric measurements. Compared to patients who did not receive any PSIO, those who underwent NAM therapy were more likely to have good to excellent frontal nasal form (Risk ratio: 2.4, 95% CI: 1.24-3.68) and vermillion border (Risk ratio: 1.8, 95% CI: 1.19-2.71). However, there were no statistically significant differences in cephalometric measurements between these groups. Additionally, there were no statistically significant differences between patients receiving NAM versus non-NAM PSIO. There was insufficient evidence to determine the impact of NAM on dental arch development. Conclusions: The preponderance of evidence in this review suggests that NAM produces benefits in nasolabial aesthetic form when compared with no appliance-based presurgical treatment. However, there is insufficient evidence to conclude whether NAM produces such benefits when compared with other passive PSIOs.
Approach to Sedation and Analgesia in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation
Authors: Dreucean Diane , Harris Jesse E. , Voore Prakruthi , Donahue Kevin R. 
Published: April 2021

Objective: To describe clinically pertinent challenges of managing sedation in COVID-19 patients on venovenous extracorporeal membrane oxygenation (VV-ECMO) and describe considerations for enhanced safety and efficacy of pharmacological agents used. Data Sources: A PubMed search was performed using the following search terms: ECMO, ARDS, sedation, COVID-19, coronavirus, opioids, analgesia, fentanyl, hydromorphone, morphine, oxycodone, methadone, ketamine, propofol, dexmedetomidine, clonidine, benzodiazepines, midazolam, lorazepam, and diazepam. Study Selection and Data Extraction: Relevant clinical and pharmacokinetic studies were considered. All studies included were published between January 1988 and March 2021. Data Synthesis: Patients with acute respiratory distress syndrome secondary to COVID-19 may progress to requiring VV-ECMO support. Agents frequently used for sedation and analgesia in these patients have been shown to have significant adsorption to ECMO circuitry, leading to possible diminished clinical efficacy. Use of hydromorphone-based analgesia has been associated with improved clinical outcomes in patients on VV-ECMO. However, safety and efficacy regarding use of other agents in this patient population remains an area of further research. Relevance to Patient Care and Clinical Practice: This review addresses clinical challenges associated with sedation management in COVID-19 patients requiring VV-ECMO support and provides potential strategies to overcome these challenges. Conclusions: Historically, sedation and analgesia management in patients requiring ECMO support have posed a challenge for bedside clinicians given the unique physiological and pharmacokinetic changes in this patient population. A multimodal strategy to managing analgesia and sedation should be used, and the use of enteral agents may play a role in reducing parenteral agent requirements.
Bilateral angle-closure during hospitalization for coronavirus disease-19 (COVID-19): A case report
Authors: Barosco Guido , Morbio Roberta , Chemello Francesca , Tosi Roberto , Marchini Giorgio 
Published: April 2021

Purpose: This report describes a case of bilateral primary angle closure (PAC) progressing to unilateral end-stage primary angle closure glaucoma (PACG) associated with treatment for coronavirus disease-19 (COVID-19) infection. Methods: A 64-year-old man came to our attention because of blurred vision after a 2-month hospital stay for treatment of COVID-19 infection. Examination findings revealed PACG, with severe visual impairment in the right eye and PAC in the left eye due to plateau iris syndrome. The patient’s severe clinical condition and prolonged systemic therapy masked the symptoms and delayed the diagnosis. Medical chart review disclosed the multifactorial causes of the visual impairment. Ultrasound biomicroscopy (UBM) aided in diagnosis and subsequent therapy. Results: The cause behind the primary angle closure and the iridotrabecular contact was eliminated by bilateral cataract extraction, goniosynechialysis, and myotic therapy. Conclusions: COVID-19 treatment may pose an increased risk for PAC. Accurate recording of patient and family ophthalmic history is essential to prevent its onset. Recognition of early signs of PAC is key to averting its progression to PACG.