bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systems Barriers to Medication Management During Hospital to Home Transitions of Older Adults With Dementia
Authors: Keita-Fakeye Maningbe , Sharma Rhea , Greyson Sylvan , Samus Quincy , Gurses Ayse , Keller Sara , Arbaje Alicia 
Published: December 2021

Abstract
The hospital-to-home transition is a high-risk period for medication errors and adverse events for older adults living with dementia. Researchers conducted a qualitative study using semi-structured interviews and participant solicited diaries. Caregivers of adults ages 55 and older were recruited to understand barriers to medication management during hospital to skilled home health care transitions. We used a human factors engineering approach to guide our understanding of systems level barriers. At least two researchers independently coded each transcript using content analysis and the ATLAS.ti software. We interviewed 23 caregivers and identified five barrier types stemming from systems breakdowns related to: (1) knowledge and information, (2) access to and use of resources and tools, (3) caregiver burden, (4) pandemic concerns, and (5) health limitations. Caregivers grappled with receiving overwhelming, insufficient, incorrect, or conflicting information, and had difficulty managing information from different sources. Latinx caregivers encountered language barriers that impeded role and task clarity. Caregivers expressed mistrust in health systems elements and inability to access resources. Caregivers were in need of additional caregiving assistance, financial aid, and tools to manage medications. Balancing multiple medications and responsibilities left caregivers burdened. The health limitations of the older adult and COVID-19 concerns related to reduced access to resources and ability to deliver and receive in person care complicated task management. Altogether these barriers reflect systems level breakdowns impeding task understanding, execution, and overall management. These findings will inform the development of interdisciplinary strategies to ensure safer care transitions.
Building and Using Data Resources for Research on Job Characteristics, Health, and Retirement
Authors: Sonnega Amanda , Fisher Gwen 
Published: December 2021

Abstract
A growing literature seeks to understand the relationship between the experience of work and important later-life outcomes. Rich longitudinal measurement of both sides of this equation in datasets such as the Health and Retirement Study (HRS) have made this research possible. These data take the form of self-reported experiences of work (such as physical demands, job flexibility, job satisfaction etc.). Increasingly, researchers are looking to add potentially complementary information on the work environment available in the Occupational Information Network (O*NET) database through a linkage using occupation and industry codes in the survey data. The session talks will describe research conducted using O*NET linked with HRS data as well as ongoing work to create a new data resource that will allow other researchers to undertake research with O*NET-HRS linked data. Each presentation will include some discussion of both the value and limits of using the linkage to O*NET. Carpenter will provide a detailed description a new project linking the 2019 O*NET data to the HRS for public use.This presentation explains the types of variables that will be made available in the O*NET-HRS occupation project and will provide examples for how the measures can be used in longitudinal HRS studies. Using O*NET-HRS linked data, Carr will present on work examining the role of preretirement job complexity in alternative retirement paths and cognitive performance. Helppie-McFall will used the linked data to discuss the role of mismatch between demands of work and workers’ ability to meet those demands in retirement decisions.
The Longitudinal Association Between Social Isolation and Cognitive Decline Among Canadian Older Adults
Authors: Mehrabi Fereshteh , Béland François 
Published: December 2021

Abstract
Social isolation is an emerging public health concern with an emphasis on its potential preventive impact on cognitive impairment. We hypothesize that change in social isolation is associated with cognitive decline over two years. Latent growth models were used to test the hypothesis using data from the FRéLE longitudinal study among 1643 Canadian community-dwelling older adults aged 65 years and over. We assessed social isolation using social participation, social networks, and support from various social ties. We found that less contact with friends and children, less social support from friends, children, and partner, and the absence of partner were significantly associated with cognitive decline. Higher baseline social participation was related to the lower rate of cognitive decline over time. Fewer contacts with grandchildren were associated with cognitive decline over time. Our study suggests that public health policies in age-friendly cities and intergenerational contacts may promote cognitive health in older adults.
How Marital Status Shapes Grandparenting Children With Disabilities
Authors: Meyer Madonna Harrington 
Published: December 2021

Abstract
How does marital status shape grandparent care work when grandchildren have disabilities? Based on 50 in-depth interviews with grandparents who provide various types of care for grandchildren with disabilities, we find that marital status shapes care work in three distinct ways: (1) Many who are married describe both grandparents working as a team to provide vital care; (2) Some who are married describe spouses, primarily grandfathers, who are either unable or unwilling to provide care; and (3) Many who are not married, primarily grandmothers, describe providing relatively high levels of care and support despite relatively low resources. While nearly all report a great deal of joy and satisfaction with their care work, those who are single, have greater care responsibilities, and fewer resources are more likely to report adverse social, emotional, physical, and financial impacts. More robust social policies could alleviate the impact of marital status on grandparent care work.
Nursing Home Post-Acute Care Specialization Groups and Financial Outcomes
Authors: Wang Xiao (Joyce) , Burr Jeffrey , Weech-Maldonado Robert , Hefele Jennifer , Boerner Kathrin 
Published: December 2021

Abstract
Nursing homes (NHs) have increasingly specialized in post-acute care (PAC). However, it remains unclear as to why some NHs engage in more specialization than the others. Furthermore, the relationship between financial outcomes and PAC specialization has not been examined using more accurate financial indicators. This study developed a NH PAC specialization typology and examined financial outcomes (i.e. total revenue per inpatient day, operating margin) of different specialization groups. We employed NH-level panel data from 2011 through 2017 and focused on over 9,000 urban NHs per year. Multiple data sources were utilized like the Certification and Survey Provider Enhanced Reporting data; Medicare Cost Reports; and Brown University’s LTCfocUS. We employed Latent Profile Analysis to develop distinct NH care specialization groups based on PAC staffing levels. This analysis revealed heterogeneous and clustered patterns of PAC staffing utilization and identified a four-group typology: “low specialization,” “mixed specialization,” “moderate PAC specialization,” and “intensive PAC specialization.” Using fixed-effects modeling, we then examined financial outcomes of the four PAC specialization groups. Although being in a group with higher level of commitment to PAC specialization was associated with higher revenues, it was not necessarily associated with higher operating margins. Further, in stratified analyses, for-profit and not-for-profit NHs showed different patterns in these associations. This suggested that although NHs compete for patients paid at higher reimbursement policies, increased costs may offset higher revenues as a result of specialization. Future studies should track financial outcome trajectories of NHs by care specialization groups in light of various payment innovations.
Social Isolation and Suicidal Ideation of Older People: The Buffering Effects of Neighborhood Social Cohesion
Authors: Bomi Choi , Jun Hey Jung , Joo Susanna 
Published: December 2021

Abstract
This study aimed to examine the buffering effect of neighborhood social cohesion on the association of social isolation and suicidal ideation among Korean older people. The sample was older adults who were 65 years old or older and participated in the Korea Health Survey 2017 collected by the Center for Disease and Prevention (N=67,835). Social isolation was measured with three indicators: living-alone, contact isolation (less than weekly contact with family, friends, or neighbors), and participation isolation (less than monthly social organization attendance). Neighborhood social cohesion was measured with two indicators: trust in neighbors and the welfare budget ratio to represent social capital and social inclusion capabilities, respectively. Multilevel logistic regression analyses were performed to estimate the dynamic relationships between social isolation, neighborhood social cohesion, and suicidal ideation. Results of the main effect indicated that social isolation is a significant risk factor for suicidal ideation and neighborhood social cohesion works as a protective factor against suicidal ideation. Results of cross-level interactions showed that the welfare budget ratio moderated the association between participation isolation and suicidal ideation (OR=0.960, p&lt;.001). The negative effect of participation isolation was reduced as the welfare budget ratio of the neighborhood increased. Neighborhood social cohesion indicators did not moderate the association between the remaining types of social isolation and suicidal ideation. The evidence from this study highlights the importance of social welfare expenditures when building suicide prevention interventions and age-friendly communities.
Promoting Health Equity Through Partnerships
Authors: Phillips Karon 
Published: December 2021

Abstract
Funded by The John A. Hartford Foundation, Trust for America’s Health’s (TFAH) Healthy Aging initiative has supported states as they develop Age-Friendly Public Health Systems (AFPHS). The goal of this national initiative is to make healthy aging a core function of state and local public health departments. Through this initiative, TFAH is working directly with states as they work to improve the health of older adults, with a particular focus on health equity. Given the increased prevalence of health disparities, prioritizing health equity has become important for many organizations. Through new partnerships and collaboration with aging services providers and health care systems, public health departments have developed innovative ways to improve the health and well-being of older adults from racial/ethnically diverse backgrounds. Areas of collaboration between the public health and aging sectors include sharing data on older adult health and working together to address social isolation.
Exploitation history of Atlantic bluefin tuna in the eastern Atlantic and Mediterranean—insights from ancient bones
Authors: Andrews Adam J , Di Natale Antonio , Bernal-Casasola Darío , Aniceti Veronica , Onar Vedat , Oueslati Tarek , Theodropoulou Tatiana , Morales-Muñiz Arturo , Cilli Elisabetta , Tinti Fausto 
Published: December 2021

Abstract
Overexploitation has directly, negatively affected marine fish populations in the past half-century, modifying not only their abundance but their behaviour and life-history traits. The recovery and resilience of such populations is dependent upon their exploitation history, which often extends back millennia. Hence, data on when exploitation intensified and how populations were composed in historical periods, have the potential to reveal long-term population dynamics and provide context on the baselines currently used in fisheries management and conservation. Here, we setup a framework for investigations on the exploitation history of Atlantic bluefin tuna (Thunnus thynnus; BFT) in the eastern Atlantic and Mediterranean by collating records of their zooarchaeological remains and critically reviewing these alongside the literature. Then, we outline how novel multidisciplinary applications on BFT remains may be used to document long-term population dynamics. Our review of literature provides clear evidence of BFT overexploitation during the mid-20th century ce. Furthermore, a strong case could be made that the intensification of BFT exploitation extends back further to at least the 19th century ce, if not the 13th–16th century ce, in the eastern Atlantic and Mediterranean. However, a host of archaeological evidence would suggest that BFT exploitation may have been intensive since antiquity. Altogether, this indicates that by the currently used management baselines of the 1970s, population abundance and complexity was already likely to have declined from historical levels, and we identify how biomolecular and morphometric analyses of BFT remains have the potential to further investigate this.
False-Positive Human Immunodeficiency Virus Test Results in Patients Receiving Lentivirus-Based Chimeric Antigen Receptor T-Cell Therapy: Case Report, Review of the Literature, and Proposed Recommendations
Authors: Villalba Julian A , Maus Marcela V , Frigault Matthew J , Zaffini Rebecca , Gandhi Rajesh T , Rosenberg Eric S , Siedner Mark J 
Published: December 2021

Abstract
There are emerging reports of false-positive HIV nucleic acid testing (NAT) in patients who have received chimeric antigen receptor (CAR) T-cell therapies. We present a case of a 66-year-old-woman with primary-refractory stage IIIA double-hit high-grade B-cell lymphoma, in whom we detected false-positive HIV-1 NAT results after receipt of a third-generation self-inactivating investigational lentivirus-based CAR T-cell therapy. We reviewed the current state of the science on HIV-1 NAT and found that all reported false-positive cases have occurred in the setting of lentivirus-based CAR T-cell therapy and testing with FDA-approved platforms targeting the 5’LTR genomic region. Herein, we offer recommendations for HIV diagnostic testing in patients undergoing this mode of therapy. Clinicians managing this patient population should be aware of cross-reactivity between these therapeutic agents and commonly used HIV-1 NAT assays.
A scoping review of knowledge authoring tools used for developing computerized clinical decision support systems
Authors: Nair Sujith Surendran , Li Chenyu , Doijad Ritu , Nagy Paul , Lehmann Harold , Kharrazi Hadi 
Published: December 2021

AbstractObjectiveClinical Knowledge Authoring Tools (CKATs) are integral to the computerized Clinical Decision Support (CDS) development life cycle. CKATs enable authors to generate accurate, complete, and reliable digital knowledge artifacts in a relatively efficient and affordable manner. This scoping review aims to compare knowledge authoring tools and derive the common features of CKATs.Materials and MethodsWe performed a keyword-based literature search, followed by a snowball search, to identify peer-reviewed publications describing the development or use of CKATs. We used PubMed and Embase search engines to perform the initial search (n = 1579). After removing duplicate articles, nonrelevant manuscripts, and not peer-reviewed publication, we identified 47 eligible studies describing 33 unique CKATs. The reviewed CKATs were further assessed, and salient characteristics were extracted and grouped as common CKAT features.ResultsAmong the identified CKATs, 55% use an open source platform, 70% provide an application programming interface for CDS system integration, and 79% provide features to validate/test the knowledge. The majority of the reviewed CKATs describe the flow of information, offer a graphical user interface for knowledge authors, and provide intellisense coding features (94%, 97%, and 97%, respectively). The composed list of criteria for CKAT included topics such as simulating the clinical setting, validating the knowledge, standardized clinical models and vocabulary, and domain independence. None of the reviewed CKATs met all common criteria.ConclusionOur scoping review highlights the key specifications for a CKAT. The CKAT specification proposed in this review can guide CDS authors in developing more targeted CKATs.
Single-Center Experience With Paraquat Exposure in Nine Patients
Authors: McKinzie Brian P , Powell Brandon D , Sljivic Sanja , Hollowell Jamie , Maxwell Eli , Nizamani Rabia , King Booker , Williams Felicia N 
Published: December 2021

Abstract
Paraquat dichloride is a widely used, highly toxic chemical herbicide and a significant cause of fatal poisonings. Toxicity is thought to be secondary to generation of reactive oxygen species. Hours after exposure, patients may experience signs and symptoms ranging from nausea to multisystem organ failure. To mitigate complications and death, immunosuppression with cyclophosphamide and corticosteroid-based therapies has shown to be an effective option in limited studies. Our objective is to report our center’s experience treating patients that had been exposed to paraquat over a 2-day period. Patients were identified using our Institutional Burn Center registry and linked to the clinical and administrative data. Demographics, length of stay (LOS), costs, and mortality were evaluated. There were nine patients admitted from the exposure. All were male. All survived. Eight were undocumented migrant farmers. The average age was 36 years (25–59 years). The average LOS was 3.3 days (2–5 days). Seventy-eight percent had cutaneous injury, but only one required debridement and placement of a skin substitute. Thirty-three percent complained of continued shortness of breath after discharge. Average total hospital cost was $28,131 ($9,500–$51,000). Paraquat is a highly toxic herbicide and exposure can be fatal if not treated promptly. Immediate decontamination and repeated pulse therapy with cyclophosphamide and methylprednisolone may be life-saving.
Associations of Inflammatory Bowel Disease and Subsequent Cancers in a Population-Based Study of Older Adults in the United States
Authors: Wang Jeanny H , D’Arcy Monica , Barnes Edward L , Freedman Neal D , Engels Eric A , Song Minkyo 
Published: December 2021

Abstract

Background
Cancer risk is elevated in patients with inflammatory bowel disease (IBD). A comprehensive investigation of cancer risk in older patients (≥66 years of age) is needed, because this understudied population is at high risk.

Methods
We performed a case-control study using Surveillance Epidemiology and End Results–Medicare data including 1 986 735 incident cancer cases (aged 66-99 years; diagnosed 1992-2015) and 200 000 controls matched by sex, age, race and ethnicity, and selection year. IBD was identified by ulcerative colitis (UC) or Crohn’s disease (CD) diagnosis codes. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for potential confounders. For colorectal cancers, we further adjusted for screening rates. We assessed confounding by medication exposure among patients with prescription drug coverage.

Results
IBD, CD, and UC were present in 0.8%, 0.3%, and 0.5% in both cancer cases and non-cancer controls. Of 51 cancers examined, IBD was statistically significantly associated with cancers of the small intestine (OR = 2.55, 95% CI = 2.15 to 3.01), intrahepatic (OR = 1.92, 95% CI = 1.47 to 2.51) and extrahepatic bile ducts (OR = 1.75, 95% CI = 1.38 to 2.22), rectum (OR = 1.61, 95% CI = 1.36 to 1.90), and colon (OR = 1.21, 95% CI = 1.10 to 1.33). CD was associated with cancers of the small intestine (OR = 4.55, 95% CI = 3.65 to 5.67), and UC was associated with cancers of the intrahepatic bile ducts (OR = 1.87, 95% CI = 1.34 to 2.61), rectum (OR = 1.80, 95% CI = 1.47 to 2.20), and colon (OR = 1.28, 95% CI = 1.14 to 1.43). After adjusting for medication exposure, IBD was not statistically significantly associated with lung cancer, melanoma, diffuse large B-cell lymphoma, and myelodysplastic syndrome.

Conclusions
In this large study among older adults (≥66 years of age), IBD was positively associated with gastrointestinal cancers. Associations with extraintestinal cancers may reflect the effect of immunosuppressive medications.
Bank Consolidation, Interest Rates, and Risk: A Post-Merger Analysis Based on Loan-Level Data from the Corporate Sector*
Authors: Juranek Steffen , Nilsen Øivind A , Ulsaker Simen A 
Published: December 2021

ABSTRACT
In this paper, we analyze the bank merger between DnB and Gjensidige Bank in 2003, ranked by market share as number one and number three in the Norwegian bank market. Focusing on loans to firms, our difference-in-differences analysis shows no increase of concentration of new loans. The concentration in affected markets (markets where both merging parties were present) developed similar to unaffected markets. Moreover, the interest rate tended to be lower in the affected markets relative to unaffected markets, but this relationship is weak and not statistically significant. The merger also affected the riskiness of loans only marginally. These weak effects could be the result of efficiency gains in the form of lower costs being pass-through to customers, and the increased market power (and consequently higher interest rates) canceled each other out. The remedial measures imposed by the Norwegian Competition Authority on the two merging parties are also likely to explain some of the modest effects of the merger. The weak effects are largely coincident with international literature showing the effects of mergers and acquisitions in the banking sector to be modest.
The Great Lakes Silviculture Library: Insights into a Case Study Platform
Authors: Moser Robert Lane , Sagor Eli S , Russell Matthew B , Windmuller-Campione Marcella A 
Published: December 2021

AbstractInnovation and knowledge exchange are critical to foster adaptive management and continual learning. Across the spectrum of knowledge exchange, ranging from peer-reviewed research to anecdotes, there is a largely untapped middle ground: real-world silvicultural case studies implemented and documented by foresters. The University of Minnesota Great Lakes Silviculture Library is a novel, freely available platform designed to enable foresters to exchange these case studies. Five years after its launch, we conducted focus groups with foresters from Minnesota and Wisconsin, USA, and Ontario, Canada, to explore the platform’s usage and value. Participants valued having access to examples of silvicultural treatments and their outcomes that they could easily digest, apply, and share. They gained new knowledge from management across administrative boundaries. They also appreciated the consistent, relatable case study format. However, participants noted that limited time was the primary barrier to wider authorship and readership. The Library enables information exchange across agencies and disciplines within natural resources, giving greater voice to practicing foresters and supplementing other sources of forestry knowledge.