bluuebunny/crossref_metadata_2025_split huggingface dataset:
High speed Power efficient Vedic arithmetic modules on Zedboard‐Zynq‐7000 FPGA
Authors: S Sujitha , Kailath Binsu J 
Published: August 2021

SummaryHardware implementation of dedicated arithmetic modules is inevitable for any signal processing system development and computational complexity of such modules could be significantly reduced with improved performance by utilizing Vedic algorithms. Five novel Vedic arithmetic modules for multiplication, square, cube, square root, and cube root are implemented on Zedboard Zynq‐7000 FPGA. A novel 4:2 compressor that uses only primitive gates in critical path is proposed to reduce partial products in the Urdhwa Tiryakhbhyam parallel multiplier achieving the best performance reported so far. Elimination of recursiveness in Antyayordashekepi‐Dwanda squarer results in reduced area while modified Dwanda squarer results in reduced delay. Anurupyena cubic module with 4:2 and 5:2 compressors is implemented from which the one with 4:2 compressor provides the least delay with more than 50% reduction with respect to that of reported cube modules. Modified Vargamula square root and modified cube root modules are also implemented incorporating pipelining, priority encoder, and padding of zero's to achieve better performance. In addition to the delay, in terms of area occupancy, power, and energy consumed (power‐delay‐product), better or comparable performance is also achieved by all the above‐mentioned modules implemented. The dedicated multiplier is used in a 64‐point FFT Implementation and results similar to existing structures are obtained.
The immunological link between neonatal lung and eye disease
Authors: Wickramasinghe Lakshanie C , van Wijngaarden Peter , Tsantikos Evelyn , Hibbs Margaret L 
Published: August 2021

AbstractBronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are two neonatal diseases of major clinical importance, arising in large part as a consequence of supplemental oxygen therapy used to promote the survival of preterm infants. The presence of coincident inflammation in the lungs and eyes of neonates receiving oxygen therapy indicates that a dysregulated immune response serves as a potential common pathogenic factor for both diseases. This review examines the current state of knowledge of immunological dysregulation in BPD and ROP, identifying similarities in the cellular subsets and inflammatory cytokines that are found in the alveoli and retina during the active phase of these diseases, indicating possible mechanistic overlap. In addition, we highlight gaps in the understanding of whether these responses emerge independently in the lung and retina as a consequence of oxygen exposure or arise because of inflammatory spill‐over from the lung. As BPD and ROP are anatomically distinct, they are often considered discreet disease entities and are therefore treated separately. We propose that an improved understanding of the relationship between BPD and ROP is key to the identification of novel therapeutic targets to treat or prevent both conditions simultaneously.
Genetic compensation between Pax3 and Pax7 in zebrafish appendicular muscle formation
Authors: Nord Hanna , Kahsay Abraha , Dennhag Nils , Pedrosa Domellöf Fatima , von Hofsten Jonas 
Published: August 2021

AbstractBackgroundMigrating muscle progenitors delaminate from the somite and subsequently form muscle tissue in distant anatomical regions such as the paired appendages, or limbs. In amniotes, this process requires a signaling cascade including the transcription factor paired box 3 (Pax3).ResultsIn this study, we found that, unlike in mammals, pax3a/3b double mutant zebrafish develop near to normal appendicular muscle. By analyzing numerous mutant combinations of pax3a, pax3b and pax7a, and pax7b, we determined that there is a feedback system and a compensatory mechanism between Pax3 and Pax7 in this developmental process, even though Pax7 alone is not required for appendicular myogenesis. pax3a/3b/7a/7b quadruple mutant developed muscle‐less pectoral fins.ConclusionsWe found that Pax3 and Pax7 are redundantly required during appendicular myogenesis in zebrafish, where Pax7 is able to activate the same developmental programs as Pax3 in the premigratory progenitor cells.
Assessment of genetic relationships among native and introduced Himalayan balsam (Impatiens glandulifera) plants based on genome profiling
Authors: Korpelainen Helena , Elshibli Sakina 
Published: August 2021

AbstractWe conducted genomic characterization based on SNP and SilicoDArT markers on the invasive Himalayan balsam (Impatiens glandulifera) plants originating from native and non‐native regions of their distribution. When genetic relationships were explored by PCoA using SNP and SilicoDArT marker data, the first, second, and third principal coordinates explained altogether 37.4% and 31.0% of the variability, respectively. Samples from the UK, Canada, and Pakistan were grouped together, while Indian plants were clearly distinct based on SNP markers but relatively close to the UK–Canada–Pakistan group based on SilicoDArT markers. Constructed trees differentiated individuals into clusters resembling the PCoA patterns. The Bayesian BAPS analysis performed for the SNP data revealed that the individuals were distributed in seven clusters, representing samples from each of the four Finnish populations, India, Pakistan, and the combination of the UK and Canada. Similar clustering was visible in the UPGMA tree. The Indian cluster did not display any ancestral gene flow with the others, while the Pakistani cluster showed ancestral gene flow only with the combined UK and Canada cluster. Furthermore, the latter cluster displayed ancestral gene flow with the Finnish populations varying from 0% to 3.1%. The BAPS analyses conducted for the SilicoDArT data differ slightly: The individuals were distributed in nine clusters, and the Indian cluster exhibited ancestral gene flow with the mixed cluster including Canadian, Pakistani, and UK samples, and one Finnish sample. The AMOVA showed that 45% and 26% of variation was present among the I. glandulifera groups/populations and the rest within them based on SNP and SilicoDArT markers, respectively. The Bayesian BAPS analyses and the gene flow networks were the most informative tools for resolving relationships among native and introduced plants. It is notable that the small sample sizes for non‐Finnish plant materials may affect the accuracy of the gene flow and other estimates.
The effect of plant size and branch traits on rainfall interception of 10 temperate tree species
Authors: Pflug Stefanie , Voortman Bernard R. , Cornelissen Johannes H. C. , Witte Jan‐Philip M. 
Published: August 2021

AbstractRainfall interception by vegetation plays an important role in the hydrological cycle. Next to rainfall characteristics, interception is influenced by tree size, crown structure and bark morphology. How tree traits determine interception across functionally and morphologically wide‐ranging tree species is poorly understood. We determined interception ratios (interception:gross precipitation) and canopy storage capacities of seven temperate deciduous broadleaved (Acer pseudoplatanus L., Betula pendula Roth, Carpinus betulus L., Fagus sylvatica L., Populus tremula L., Sorbus aucuparia L.) and three evergreen coniferous tree species (Picea abies (L.) Karsten, Pinus sylvestris L., Pseudotsuga menziesii (Mirb.) Franco) as well as the influence of various tree traits on interception parameters. Interception was measured directly with natural rainfall by means of gravimetry on potted trees, 2–8 m tall, for seven consecutive months. Our results show that (a) the coniferous species had larger canopy storage capacities and larger interception ratios than the broadleaved species both during (summer) and outside the growing season (winter); (b) the absolute tree interception (in kg) of the broadleaved species was positively related to stem diameter at breast height, tree and crown height, maximum branch length, the total branch surface area and above ground dry weight; and (c) interception per unit crown projected area (in mm) of all species was positively related to branch length and branch surface area per unit crown projected area. These results can be used to estimate interception parameters from plant traits and to simulate interception losses of trees in a more reliable manner.
Morning and evening salivary cortisol levels in patients with chronic widespread pain and those at high risk
Authors: Begum Nayab , Taylor Jason R , Brown Christopher , Rajan Jonathan , Keevil Brian , Pye Emily , Rainey Timothy , Jones Anthony 
Published: August 2021

AbstractBackgroundHypothalamic‐Pituitary‐Adrenal (HPA) axis dysregulation has been implicated in chronic widespread pain (CWP); the hallmark of fibromyalgia (FM). This is the first study to compare HPA axis changes in individuals with CWP and those at high risk of symptom development.MethodsWe sought to determine differences in morning and evening salivary cortisol levels in FM (n = 19), those at‐risk (n = 20) and pain‐free controls (n = 17). Risk factors included non‐CWP pain, somatic symptoms, illness behaviour and sleep disturbance. We conducted the study in the absence of centrally acting medication, to address limitations of previous research.ResultsRepeated measures ANOVA revealed significant main effects of group (p = 0.003), and time of day (p = 0.002), with no significant interaction. Cortisol levels were higher in FM (p = 0.027) and at‐risk (p = 0.003) groups, compared to controls, but there was no significant difference between FM and at‐risk groups. The main effect of group remained significant with sleep problems (p = 0.021) and life events (p = 0.007), but was not significant with anxiety (p = 0.076) or depression (p = 0.098) scores as covariates. With sleep problems as a covariate, cortisol levels remained significantly higher only in the at‐risk group (p = 0.017).ConclusionsThis study indicates elevated salivary cortisol in FM and those at high risk, and identifies anxiety, depression and sleep problems as potential contributing factors. The results shed light on the dynamic relationship between stress, mood and sleep disorders and the brain's resilience to pain.SignificanceThis study examines neurobiological changes in chronic widespread pain and high risk individuals. One strength of the study is the absence of centrally acting medication. We found high salivary cortisol common to Fibromyalgia and those at risk and identified contributing factors. Our results offer insight into the early mechanistic changes underlying Fibromyalgia development and open up possibilities for early diagnosis and prevention.
Advanced cathode materials in dual‐ion batteries: Progress and prospect
Authors: Li Wen‐Hao , Wu Xing‐Long 
Published: August 2021

AbstractDual‐ion batteries (DIBs) utilize the working mechanism, that is, anions and cations participate in electrochemical reactions on the cathode and anode materials to achieve energy storage simultaneously. The high potential of anions de‐/intercalation endows DIBs with high energy density. However, the relatively low specific capacity and poor interface stability limit the further development of DIBs. Therefore, improving the performance of cathode materials has become the key to promoting the practical application of DIBs. In this review, a variety of DIBs cathode materials are classified in detail and their energy storage mechanism and typical characteristics are comprehensively summarized. Finally, the rules and corresponding strategies which should be followed in the design of high energy cathode materials are proposed, and the potential development direction of DIBs in the future is summarized.
Recent advances in field‐effect transistor sensing strategies for fast and highly efficient analysis of heavy metal ions
Authors: Liu Chengbin , Ye Ziwei , Wei Xiaojie , Mao Shun 
Published: August 2021

AbstractHeavy metal ions are highly toxic for living organisms especially after bioaccumulation and biomagnification, which possess a serious threat to human health and ecological environment. The rapid, portable, and efficient analytical methods are urgently needed for the determination of heavy metals in different media. Due to the unique advantages of field‐effect transistor (FET) sensors including fast response, easy manipulation, small size, and high sensitivity, FET sensor has become a novel strategy for heavy metal ion monitoring and numerous attempts have been made for the analysis of various heavy metal ions (e.g., mercury, lead, arsenic, copper, cadmium, iron, and silver) in the past decade. Thus, it is of urgent need to systematically summarize recent advances of FET sensing strategies in fast and highly efficient detection of heavy metal ions. In this review, the representative FET sensing platforms for heavy metal ions are introduced with a focus on their working principle and sensing performance. Moreover, the limitations of current FET sensors as well as the gap between the research achievements and practical application requirements are also discussed. At last, future directions of FET sensors in heavy metal ion analysis are proposed, which provides guidance to the further development of FET sensors for monitoring heavy metal ions as well as other chemicals.
Surface cracks—geomorphological indicators for late Quaternary halotectonic movements in Northern Germany
Authors: Hardt Jacob , Norden Ben , Bauer Klaus , Toelle Ole , Krambach Jenny 
Published: August 2021

AbstractLoading and unloading effects of the Scandinavian Ice Sheet triggered halotectonic movements in Northern Germany. We present newly detected geomorphological features—termed surface cracks—which indicate a relation between ice sheet‐induced salt movement and surface processes. As a part of the Central European Basin System, numerous Zechstein salt structures are abundant in the North German Basin. On the basis of high‐resolution digital terrain data, more than 160 surface cracks were mapped in Northern Germany, which were grouped into 30 clusters. Almost all of the surface cracks occur above the top regions of Zechstein salt structures. The surface cracks can be several kilometres long, up to more than 20 m deep and more than 100 m wide. The comparison of the shape of the salt structures and the orientation of the cracks reveals a geometric dependency, indicating that the cracks preferably occur near the crest margins of the salt structures. Furthermore, 3D seismic data from two sites show that subsurface faults originating from salt movement exist beneath the surface cracks. We interpret the cracks as surface ruptures due to ice sheet‐induced halotectonic movements. The cracks occur in a variety of Quaternary sediments and landforms. This indicates that widespread halokinetic movements occurred in the region after the last (Weichselian) deglaciation and likely before the thawing of the permafrost, possibly in a time frame from c. 30–20 ka until c. 15 ka.
Protective effects of tea extracts against alcoholic fatty liver disease in mice via modulating cytochrome P450 2E1 expression and ameliorating oxidative damage
Authors: Li Bang‐Yan , Mao Qian‐Qian , Gan Ren‐You , Cao Shi‐Yu , Xu Xiao‐Yu , Luo Min , Li Hang‐Yu , Li Hua‐Bin 
Published: August 2021

AbstractThe alcoholic fatty liver disease (AFLD) has been a severe public health problem. Oxidative stress is involved in the initiation and progression of AFLD. Tea is a popular beverage worldwide with strong antioxidant activity. In this research, our purpose is to explore and compare the effects of 12 selected teas on AFLD. The ethanol liquid diet was used to feed the mice, and 12 tea extracts were administrated at 200 mg/kg body weight every day for 4 weeks. The results showed that the application of several tea extracts exhibited different inhibitory effects on lipid accumulation induced by sub‐acute alcohol consumption based on the determination of triglyceride concentration and the histological alteration in the liver. In addition, several teas significantly decreased serum alanine aminotransferase and aspartate aminotransferase activities, inhibited the cytochrome P450 2E1 expression, and promoted alcohol metabolism (p < .05). Besides, compared with the model group, several teas obviously elevated superoxide dismutase and glutathione peroxidase activities as well as glutathione content, and remarkably decreased malondialdehyde level (p < .05). In general, Fried Green Tea, Fenghuang Narcissus Oolong Tea, and Pu‐erh Dark Tea possessed potential preventive effects on AFLD. Moreover, the main phytochemicals in the three tea extracts were determined and quantified via high‐performance liquid chromatography, and the most commonly detected ingredients were catechins and caffeine, which could exert the protective effects on AFLD.
Dietary intake of creatine and risk of medical conditions in U.S. older men and women: Data from the 2017–2018 National Health and Nutrition Examination Survey
Authors: Ostojic Sergej M. , Korovljev Darinka , Stajer Valdemar 
Published: August 2021

AbstractWe examined dietary intake of creatine in U.S. men and women aged 65 years and over, and evaluated the association between creatine intake and risk of self‐reported medical conditions, and physical functioning/disability variables using data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES). The NHANES 2017–2018 target population included the noninstitutionalized civilian resident population of the United States aged 65 years and over. Detailed dietary intake data from NHANES elderly were obtained by dietary interview component through a 24‐h dietary recall interview, with estimated individual values for total grams of creatine consumed per day for each respondent. A threshold for dietary intake of creatine used to calculate risk between creatine intake and medical conditions was set at 1.00 g/day. The sample population included 1500 participants aged 65 years and older, of which 1221 individuals (627 men and 594 women) provided detailed dietary data via a dietary interview. Creatine intake across all participants was 0.76 ± 0.79 g/day (95% CI from 0.72 to 0.81). As much as 70% of U.S. elderly consume <1.00 g of creatine per day, with about 1 in 5 individuals (19.8%) consume no creatine at all. Elderly with the suboptimal intake of creatine were found to have 2.62 times higher risk of angina pectoris (adjusted OR = 2.62, 95% CI from 1.14 to 6.01, p = .023) and 2.59 times higher risk of liver conditions (adjusted OR = 2.59, 95% CI from 1.23 to 5.48, p = .013), compared with older counterparts who consume ≥1.00 g of creatine per day after controlling for demographic and nutritional variables. The considerable shortage of dietary creatine is associated with an increased risk of heart and liver conditions, which calls for public measures that foster diets rich in creatine‐containing foods, and additional research to investigate the role of creatine in age‐related diseases.
Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
Authors: Ren Qian‐Nan , Zhang Hong , Sun Chao‐Yue , Zhou Yu‐Feng , Yang Xue‐Feng , Long Jian‐Wu , Li Xiao‐Xing , Mai Shi‐Juan , Zhang Mei‐Yin , Zhang Hui‐Zhong , Mai Hai‐Qiang , Chen Min‐Shan , Zheng X.F. Steven , Wang Hui‐Yun 
Published: August 2021

Abstract

Background and Aims
Androgen receptor (AR) has been reported to play an important role in the development and progression of man’s prostate cancer. Hepatocellular carcinoma (HCC) is also male‐dominant, but the role of AR in HCC remains poorly understood. Mechanistic target of rapamycin complex 1 (mTORC1) also has been reported to be highly activated in HCC. In this study, we aimed to explore the role of AR phosphorylation and its relationship with mTORC1 in hepatocarcinogenesis.

Approach and Results
In vitro experiment, we observed that mTORC1 interacts with hepatic AR and phosphorylates it at S96 in response to nutrient and mitogenic stimuli in HCC cells. S96 phosphorylation promotes the stability, nuclear localization, and transcriptional activity of AR, which enhances de novo lipogenesis and proliferation in hepatocytes and induces liver steatosis and hepatocarcinogenesis in mice independently and cooperatively with androgen. Furthermore, high ARS96 phosphorylation is observed in human liver steatotic and HCC tissues and is associated with overall survival and disease‐free survival, which has been proven as an independent survival predictor for patients with HCC.

Conclusions
AR S96 phosphorylation by mTORC1 drives liver steatosis and HCC development and progression independently and cooperatively with androgen, which not only explains why HCC is man‐biased but also provides a target molecule for prevention and treatment of HCC and a potential survival predictor in patients with HCC.
The association between Urban and Rural Resident Basic Medical Insurance and depressive symptoms among Chinese middle‐aged and older adults: Evidence from the China Health and Retirement Longitudinal Study
Authors: Sun Jian , Yao Nengliang , Lyu Shoujun 
Published: August 2021

AbstractIt is unclear that whether Urban and Rural Resident Basic Medical Insurance (URRBMI) is associated with depressive symptoms among middle‐aged and older adults. To fulfill this research gap, this study aimed to investigate the association between URRBMI and depressive symptoms among the middle‐aged and older adults in China. This data of this study was sourced from the 2018 wave of China Health and Retirement Longitudinal Study (CHARLS). Ordinary least squares (OLS) regression models were used to explore the association between URRBMI and depressive symptoms. Instrumental variable (IV) method was employed to address potential endogeneity problem which is caused by reverse causation and omitted variable bias. Propensity score matching (PSM) and doubly robust estimation were employed to conduct robustness checks. We provide robust evidence indicating that participation of URRBMI was significantly correlated with a reduced depression score. Moreover, we find that improving the utilization of inpatient and outpatient care may be important channels through which URRBMI relieved depressive symptoms.
Ultrafast presodiation of graphene anodes for high‐efficiency and high‐rate sodium‐ion storage
Authors: Zheng Ganyu , Lin Qiaowei , Ma Jiabin , Zhang Jun , He Yan‐Bing , Tang Xian , Kang Feiyu , Lv Wei , Yang Quan‐Hong 
Published: August 2021

AbstractThe low initial Coulombic efficiency (ICE) is a significant problem hindering the practical uses of carbon anodes in sodium‐ion batteries (SIBs), especially for the carbons with large surface area. Presodiation is an effective way to solve the above problem, but it always needs complicated operations and cannot suppress the unavoidable electrolyte decomposition in the assembled battery. Herein, we develop an ultrafast chemical presodiation method for reduced graphene oxide (rGO) using sodium naphthalene (Na‐Nt) dissolved in dimethoxyethane (DME) solvent as a presodiation reagent. The presodiation effectively improves the ICE of rGO to 96.8% and forms an artificial solid electrolyte interphase (SEI) on its surface due to the decomposition of the formed complex between Na+ and DME. The formed artificial SEI suppresses the excessive decomposition of electrolytes in the assembled battery, leading to a formation of uniform and inorganic component–rich SEI on rGO surface, which enables a rapid interfacial ion transfer. Therefore, the presodiated rGO showed excellent rate performance with a high capacity of 198.5 mAh g−1 at 5 A g−1. Moreover, excellent cycle stability indicated by the high capacity retention of 68.4% over 1000 cycles was also achieved, showing the potential to promote the practical uses of high‐rate rGO anode in SIBs.image