bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiobiological modeling of radiation-induced acute mucosal toxicity (oral mucositis and pharyngeal mucositis): A single-institutional study of head-and-neck carcinoma
Authors: Singh Balbir , Singh Gaganpreet , Oinam Arun Singh , Kumar Vivek , Vashistha Rajesh , Sidhu Manjinder Singh , Singh Maninder 
Published: October 2021

ABSTRACT

Purpose/Objective(s):
This study aimed to estimate the fitting parameters of sigmoidal dose–response (SDR) curve of radiation-induced acute oral and pharyngeal mucositis in head-and-neck (H and N) cancer patients treated with Intensity Modulated Radiation Therapy (IMRT) for the calculation of normal tissue complication probability (NTCP).

Materials and Methods:
Thirty H-and-N cancer patients were enrolled to model the SDR curve for oral and pharyngeal mucositis. The patients were evaluated weekly for acute radiation-induced (ARI) oral and pharyngeal mucositis toxicity, and their scoring was performed as per the common terminology criteria adverse events version 5.0. The radiobiological parameters, namely n, m, TD50, and γ50 were calculated from the fitted SDR curve obtained from the clinical data of H-and-N cancer patients.

Results:
ARI toxicity for oral and pharyngeal mucosa in carcinoma of H-and-N cancer patients was calculated for the endpoint oral mucositis and pharyngeal mucositis. The n, m, TD50, and γ50 parameters from the SDR curve of Grade 1 and Grade 2 oral mucositis were found to be [0.10, 0.32, 12.35 ± 3.90 (confidence interval [CI] 95%) and 1.26] and [0.06, 0.33, 20.70 ± 6.95 (CI 95%) and 1.19] respectively. Similarly for pharyngeal mucositis, n, m, TD50, and γ50 parameters for Grade 1 and Grade 2 were found to be [0.07, 0.34, 15.93 ± 5.48 (CI. 95%) and 1.16 ] and [0.04, 0.25, 39.02 ± 9.98(CI. 95%) and 1.56] respectively.

Conclusion:
This study presents the fitting parameters for NTCP calculation of Grade 1 and Grade 2 ARI toxicity for the endpoint of oral and pharyngeal mucositis. The provided nomograms of volume versus complication and dose versus complication for different grades of oral mucositis and pharyngeal mucositis help radiation oncologists to decide the limiting dose to reduce the acute toxicities.
Radiobiological modeling of radiation-induced acute rectal mucositis: A single-institutional study of cervical carcinoma
Authors: Singh Balbir , Singh Gaganpreet , Oinam Arun Singh , Kumar Vivek , Vashistha Rajesh , Sidhu Manjinder Singh , Singh Maninder 
Published: October 2021

ABSTRACT

Purpose:
This study aimed to estimate the fitting parameters of sigmoidal dose–response (SDR) curve of radiation-induced acute rectal mucositis in pelvic cancer patients treated with Intensity Modulated Radiation Therapy (IMRT) for the calculation of normal tissue complication probability (NTCP).

Materials and Methods:
Thirty cervical cancer patients were enrolled to model the SDR curve for rectal mucositis. The patients were evaluated weekly for acute radiation-induced (ARI) rectal mucositis toxicity and their scoring was performed as per Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. The radiobiological parameters, namely n, m, TD50, and γ50 were calculated from the fitted SDR curve obtained from the clinical data of cervical cancer patients.

Results:
ARI toxicity for rectal mucosa in carcinoma of cervical cancer patients was calculated for the endpoint rectal mucositis. The n, m, TD50, and γ50 parameters from the SDR curve of Grade 1 and Grade 2 rectal mucositis were found to be 0.328, 0.047, 25.44 ± 1.21 (confidence interval [CI]: 95%), and 8.36 and 0.13, 0.07, 38.06 ± 2.94 ( CI: 95%), and 5.15, respectively.

Conclusion:
This study presents the fitting parameters for NTCP calculation of Grade 1 and Grade 2 ARI rectal toxicity for the endpoint of rectal mucositis. The provided nomograms of volume versus complication and dose versus complication for different grades of rectal mucositis help radiation oncologists to decide the limiting dose to reduce the acute toxicities.
The Use of Dental Photography in Saudi Arabia
Authors: Alghulikah Khaled 
Published: October 2021

Introduction:
Dental photography has always been an important aspect of the practice. The basic goal of digital dental photography is to capture the clinical symptoms of the oral cavity as accurately as possible. Secondary applications include dento-legal documentation, teaching, communication, portfolios, and marketing as a spin-off. This study aimed to assess the practice of photography documentation among dental students and dental practitioners in Riyadh using a cross-sectional observational study.

Materials and Methods:
This cross-sectional study was conducted using a self-administered survey distributed online. The sample included dental students (5th and 6th year), dental interns, postgraduate residents, and specialists. Frequency distribution and Chi-square tests were performed to compare the participant's responses.

Results:
A total of 218 dental practitioners were completed a structured, self-administered online questionnaire. The majority of the participants were dental interns and specialists, and more than 70% had 10 years or less of experience. Eighty-six percentage study participants reported using photography in their practices. Mobile phones were the most commonly used devices among dental practitioners.

Conclusions:
The results of the current study showed that the majority of dental practitioners believed that photography is essential in modern dental practice. However, to implement photography in dental practice, clarification of the general guidelines and the need for obtaining written consent must be explained to the patient. Furthermore, there is a need to incorporate photography within the dental curriculum.
Association of Shisha Smoking with Acute Otitis Media in Men
Authors: Binkhamis Khalifa , Alsaeed Abdulelah Hamad , Alfehaid Sultan Nasser , Almetary Rakan J. , Alshahrani Abdulaziz Saeed , Alduhayyim Abdulrahman H. , Alanazi Waleed Suliman 
Published: October 2021

Objectives:
The objective of this study is to determine the possible associations between acute otitis media (AOM) and shisha smoking, cigarette smoking, and vaping in adults.

Materials and Methods:
The study was carried out from August 2019 to April 2020 using a case-control design. The sample consisted of 144 male participants from King Saud University Medical City aged 18–55 years, of whom 72 were cases, i. e., diagnosed by a physician with AOM, and 72 were controls, i.e. diagnosed with a physical injury with no history of AOM. The participants were interviewed over the phone based on a validated questionnaire by the WHO and were evaluated for shisha smoking, cigarettes smoking, and vaping status.

Results:
Of the 144 patients originally contacted, 136 (67 cases and 69 controls) were included in the analysis. The total number of participants who smoked any type of tobacco was 51 (37.5%). Among the 51 general smokers, 54.9% had a history of AOM with odds ratio of 1.436 (confidence interval [CI] 0.715–2.884, P = 0.308). Among shisha smokers, 70% developed AOM with odds ratio of 2.774 (CI 0.996–7.721, P = 0.045). Among cigarette smokers, 53.6% had a history of AOM with odds ratio of 1.287 (CI 0.617–2.681, P = 0.501). The number of vape users was too low to produce any significant results.

Conclusion:
The study found a significant association between shisha smoking and AOM among adult men in Riyadh. This finding correlates with what previous studies found about the dangers of tobacco consumption.
Effect of Preconditioning on Retention of Glass Ionomer Pit and Fissure Sealant
Authors: Zaghloul Samaa A. , El-Sayed Safaa R. , Mohamed Eman A. R. 
Published: October 2021

Purpose:
Caries prevention using fissure sealants is directly proportional to their retention. This in vivo study evaluated the effect of preconditioning on retention of glass ionomer (GI) fissure sealant, in maxillary and mandibular primary and permanent teeth.

Subjects and Methods:
Two hundred and forty teeth in 30 children of 6-8 years age range were involved. In all participants, the second primary and the first permanent molars in each quadrant were investigated following split-mouth design; so that, selected teeth in the right side had their pits and fissures conditioned before GI sealant application (Group A: n = 120 teeth). In the left side, however, the same sealant was applied without preconditioning (Group B: n = 120). According to Simonsen's sealant retention criteria, clinical assessment was performed at 3, 6, and 9 months. Data were gained then statistically analyzed using Chi-square test.

Results:
A significant difference (P ≤ 0.05) was evident between both groups at the three assessment intervals, with better sealant retention in preconditioned group. Although no significant difference appeared between primary and permanent teeth, maxillary teeth were significantly better in sealant retention than mandibular ones.

Conclusions:
Preconditioning enhanced GI sealant retention, more durable caries prevention can be thus provided easily with low cost.
Microlocal Category for Weinstein Manifolds via the h-Principle
Authors: Shende Vivek 
Published: October 2021

On a Weinstein manifold, we define a constructible co/sheaf of categories on the skeleton. The construction works with arbitrary coefficients, and depends only on the homotopy class of a section of the Lagrangian Grassmannian of the stable symplectic normal bundle. The definition is as follows. Take any, possibly with high codimension, exact embedding into a cosphere bundle. Thicken to a hypersurface, and consider the Kashiwara–Schapira stack along the thickened skeleton. Pull back along the inclusion of the original skeleton.
Gromov's h-principle for contact embeddings guarantees existence and uniqueness up to isotopy of such an embedding. The invariance of microlocal sheaves along such an isotopy is well known. We expect, but do not prove here, invariance of the global sections of this co/sheaf of categories under Liouville deformation.
INTRODUÇÃO A UMA ESPIRITUALIDADE SEM DEUS
Authors: Melo Antonio Alves de 
Published: October 2021

Este ensaio procura definir o horizonte a partir do qual responde-se a três questões: pode-se viver sem religião? Deus existe? Qual é a espiritualidade para os ateus? Sem a pretensão de fazer uma abordagem profunda, apresento algumas notas de enfoque mais teológico, tomando como referência o livro de André Comte-Sponville, O Espirito do ateísmo. Situado nesse horizonte o ateísmo não se reduz à simplória negação da existência de Deus.
Palavras-chave: Existência de Deus. Ateísmo. Espiritualidade.

Abstract
This essay seeks to define the horizon from which three questions are answered: can one live without religion? Does God exist? What is spirituality for atheists? Without the intention of taking a deep approach, I present some notes more on theological focus, taking as reference the book entitled of André Comte-Sponville, The Spirit of Atheism. Situated in this horizon, atheism is not reduced to the simple denial of God's existence.
Keywords: Existence of God. Atheism. Spirituality.
AS INJUSTIÇAS E AS VACAS DE BASÃ EM AMÓS, ONTEM E HOJE
Authors: Jacaúna Neto Antonio Francisco , Guimarães Simone Furquim 
Published: October 2021

Esse artigo tem como objetivo fazer uma leitura da situação pela qual o mundo está passando, à luz de uma releitura do livro do profeta Amós. Para isso, foi utilizada uma revisão bibliográfica na análise hermenêutica de alguns textos para explicitar elementos de compreensão, especialmente ligados à questão da injustiça. Dentre estes textos analisados, pesquisou-se Am 4,1-3, fazendo um corte da leitura feminista, oferecendo aqui uma possível interpretação e esclarecimento sobre à menção do profeta às “Vacas de Basã”. Esse artigo pretende explicitar a temática sobre as injustiças do passado e do momento pandêmico que o mundo passa, inclusive no uso do discurso religioso de “um certo” posicionamento cristão.
Palavras-chave: Profetismo. Injustiças. Pandemia. Juízo Divino.

Resumen
Este artículo tiene como objetivo hacer uma lectura de la situación por la que atraviesa El mundo, a la luz de uma recelctura del libro del profeta Amós. Para ello, se utilizo una revisión bibliográfica en El análisis hermenêutico de algunos textos para explicar elementos de comprensión, especialmente vinculados al tema de la injuticia. Entre estos textos analizados, se investigo la Am 4, 1-3, haciendo um corte de la lectura feminista, ofreciendo aqui, uma posible interpretación y aclaración sobre la mención del profeta a las “Vacas de Basã”. Este artículo pretende aclarar el tema sobre las injusticias del pasado y el momento pandêmico que atraviesa El mundo, incluyendo el uso del discurso religioso de “una cierta” posición cristiana.
Palabras-clave: Profetismo. Injusticias. Pandemia. Juicio Divino.
Uji Aktivitas Antioksidan Krim Ekstrak Daun Mengkudu ( Morinda Citrifolia L.) Berbasis Vanishing Cream
Authors: Sari Dessy Erliani Mugita , Ernanda Thessa Happy 
Published: October 2021

Daun mengkudu (Morinda citrifolia L.) adalah sumber antioksidan alami karena mengandung senyawa fenol dan flavonoid. Daun mengkudu di ekstrak secara maserasi dengan pelarut etanol 96%. Dalam penelitian eksperimental ini dilakukan pembuatan krim ekstrak daun mengkudu, pengujian aktivitas antioksidan dengan uji penangkapan radikal DPPH (2,2-di(4-tert-octylphenyl)1-picryl-Hydrazyl) dengan menggunakan spekrofotometri Uv-Vis dan uji parameter sifat fisik krim ekstrak daun mengkudu. Krim ekstrak daun mengkudu dengan basis Vanishing Cream diformulasikan menjadi tiga formulasi, dengan variasi konsentrasi ekstrak sebanyak 5%, 10%, 15%. Uji sifat fisik krim meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar dan uji daya lekat. Kadar total fenol 64,9mgGAE/g, dan kadar total flavonoid 0,21%mg/QE/g, antioksidan ekstrak daun mengkudu diperoleh hasil 137/527 µg/ml, aktivitas antioksidan krim daun mengkudu IC50 pada FI (5%) 124,724, FII (10%) 123,333, FIII (15%) 121,286. Krim ekstrak etanol daun mengkudu didapatkan hasil yang baik, memenuhi syarat, SNI, dan kriteria yang baik. Aktivitas antioksidan nilai IC50 formula yang lebih baik yaitu Formula III (15%) 121,286 yang artinya mempunyai aktivitas antioksidan sedang.
Analisis Kesulitan Siswa Kelas V dalam Menentukan Ide Pokok Paragraf
Authors: Oktafiani Eka Nur , Irawan Dedy 
Published: October 2021

Kesulitan dalam belajar merupakan kesulitan yang selalu dialami oleh siswa dalam proses pembelajaran di Sekolah Dasar. Kesulitan dalam membuat paragraf seringkali menjadi masalah yang dialami oleh siswa setiap pembelajaran Bahasa Indonesia. Paragraf adalah salah satu materi yang ada di dalam pelajaran Bahasa Indonesia. Kesulitan yang dialami siswa dalam materi paragraf diantaranya adalah kesulitan dalam menentukan ide pokok. Kesulitan dalam menentukan ide pokok menjadi masalah cukup serius yang dialami oleh siswa di SD kelas V. Penelitian ini bertujuan untuk (1) Mengetahui kesulitan siswa dalam menentukan ide pokok paragraf di kelas V SD N 2 Dukuhwaluh (2) Mengetahui faktor yang menyebabkan siswa mengalami kesulitan dalam menentukan ide pokok paragraf. Penelitian ini adalah penelitian deksriptif kualitatif dengan metode studi kasus. Teknik pengumpulan data dengan cara observasi, wawancara dan analisis dokumen. Teknik analisis data dari reduksi data, penyajian data dan verifikasi. Hasil penelitian menunjukan bahwa ditemukan dua siswa yang mengalami kesulitan dalam menentukan ide pokok di kelas V SD N 2 Dukuhwaluh. Kesulitan dalam menentukan letak ide pokok paragraf dan kesulitan dalam menulis ide pokok paragraf. Penelitian ini sangat berguna untuk mengetahui permasalahan yang terjadi setiap tahun di Sekolah Dasar kelas V.
Prospectiva del nuevo mundo educativo
Authors: Méndez-Mantuano Marcel Oswaldo , Valdez Amanda Yolanda Lozada , Quizhpi Jorge Christian Plaza , Rogel Danny Rafael Plúas , Ladines Karla Vanessa Ochoa 
Published: October 2021

Alrededor del mundo se perciben cambios acelerados en todos los ámbitos que forman la cotidianidad, quienes modulan las nuevas estructuras relacionales entre personas y de éstas con su entorno. Estos cambios germinan de la acelerada transformación tecnológica, de la masificación de los medios de producción y de la globalización económica y social. Sin embargo, el ecosistema educativo parece haber sufrido una parálisis evolutiva, o al menos sus cambios no son percibidos con la misma intensidad que los derivados de los aspectos antes mencionados. Por lo tanto, es necesario dar una lectura aproximada de las nuevas realidades que se despliegan en la educación contemporánea. La presente investigación trata de abordar las ideas principales que se desarrollan en el libro “La educación en su laberinto: análisis y propuestas para una salida”, el mismo que esboza las concepciones del denominado “Nuevo Mundo Educativo”. Estos postulados representan la propuesta para el desarrollo de un modelo educativo que sea adaptable a los diferentes paradigmas educativos, sin llegar a denominarse una nueva teoría educativa. Se analizó la disputa hegemónica de la educación actual, la pedagogía que representa un equilibrio entre las nuevas ignorancias y los nuevos aprendizajes, y el detalle de la reconstrucción de la biografía docente.

Accelerated changes are perceived around the world in all the areas that make up daily life, which modulate the new relational structures between people and between people and their environment. These changes germinate from the accelerated technological transformation, from the massification of the means of production and from economic and social globalization. However, the educational ecosystem seems to have suffered an evolutionary paralysis, or at least its changes are not perceived with the same intensity as those derived from the aspects. Therefore, it is necessary to give an approximate reading of the new realities that are unfolding in contemporary education. The present investigation tries to approach the main ideas that are developed in the book “Education in its labyrinth: analysis and proposals for a way out”, the same one that outlines the conceptions of the so-called “New Educational World”. These postulates represent the proposal for the development of an educational model that is adaptable to the different educational paradigms, without being called a new educational theory. The hegemonic dispute of current education, the pedagogy that represents a balance between new ignorance and new learning, and the detail of the reconstruction of the teacher biography were analyzed.
Emboli Air Ketuban
Authors: Ratih kumala fajar apsari  , Suryono Suwondo Bambang 
Published: October 2021

Emboli cairan amnion (EAK) adalah komplikasi kehamilan yang jarang namun membawa angka mortalitas yang tinggi. Patogenesis yang tepat dari kondisi ini masih belum diketahui. Emboli air ketuban (EAK) atau amniotic fluid embolism (AFE) atau anaphylactoid syndrome of pregnancy adalah salah satu komplikasi kehamilan yang paling membahayakan. Cairan ketuban, debris fetal diduga menyebabkan kolaps kardiovaskular dengan cara memicu reaksi imun/anafilaktoid maternal. Patofisiologi EAK hingga kini masih belum jelas tetapi diduga melibatkan kaskade immunologis. Kematian maternal bisa terjadi karena cardiac arrest mendadak, perdarahan karena koagulopati, dan kegagalan organ multipel dengan acute respiratory distess syndrome (ARDS). Gejala dan tanda EAK antara lain dispnea akut, batuk, hipotensi, sianosis, bradikardia fetal, ensefalopati, hipertensi pulmoner akut, koagulopati, dan sebagainya. Diagnosis EAK adalah bersifat klinis dan ditegakkan setelah menyingkirkan kemungkinan penyebab lain. Penatalaksanaan bersifat suportif dan memerlukan persalinan janin jika diperlukan, support respiratorik, dan support hemodinamik. Prognosis maternal setelah EAK masih sangat buruk meski tingkat survival janin sekitar 70%. Pasien dengan EAK paling baik dikelola di unit perawatan kritis oleh tim multidisiplin dan dengan manajemen supportif.

Amniotic Fluid Embolism
Abstract
Amniotic fluid embolism (AFE) is a rare complication of pregnancy carrying a high mortality rate. The exact pathogenesis of the condition is still not known. Amniotic fluid embolism (AFE) or anaphylactoid syndrome of pregnancy is one of the most dangerous pregnancy complications. Amniotic fluid, fetal debris is thought to cause cardiovascular collapse by triggering a maternal immune / maternal anaphylactoid reaction. The pathophysiology of AFE remains unclear but is thought to involve an immunological cascade. Maternal deaths may occur due to sudden cardiac arrest, bleeding due to coagulopathy, and multiple organ failure with ARDS. AFE symptoms and signs include acute dyspnea, cough, hypotension, cyanosis, fetal bradycardia, encephalopathy, acute pulmonary hypertension, coagulopathy. Management is supportive, respiratory support, and haemodynamic support. The maternal prognosis is very poor even though the survival rate of the fetus is about 70%. Patients with AFE are best managed in a critical care unit by a multidisciplinary team and management is largely supportive
GESTÃO DA QUALIDADE APLICADA EM CANTEIROS DE OBRAS
Authors: Leão Matheus Clausen , Marco Gerson de , Florian Fabiana 
Published: October 2021

O setor da Construção Civil é de grande importância ao desenvolvimento econômico, pois representou 6,2% do PIB brasileiro 2020, segundo CBIC (Câmara Brasileira da Indústria da Construção) (2019) e está diretamente relacionado com a qualidade de vida das pessoas. Diante da competitividade inerente ao setor, cada vez mais, as empresas construtoras visam manter a qualidade dos produtos ofertados, aumentar a produtividade, reduzir custos e desperdícios, evitando acidentes de trabalho e ao atendimento dos seus compromissos contratuais. O canteiro de obras está entre as atividades mais importantes para o desenvolvimento de uma edificação, pois contribui para o bom andamento da obra. A ausência de gestão do canteiro de obras é uma das causas principais de baixa produtividade, falta de segurança e desperdício de materiais. Desta forma, a gestão do canteiro é de extrema importância, pois permite que a logística seja eficiente, reduz custos desnecessários, além de permitir o atendimento às programações das atividades. Isto posto, este trabalho objetiva apresentar conceitos e Aplicações da Qualidade Aplicada em Canteiros de Obras, destacando seus benefícios. A metodologia utilizada foi a revisão bibliográfica, embasada em livros, artigos, monografias, sites e documentos relevantes ao tema.
Sử dụng hai động mạch ngực trong làm tất cả các cầu nối động mạch vành tại viện Tim TP. Hồ Chí Minh: Kết quả dài hạn
Authors: Dũng Văn Hùng , Bình Phạm Thanh , Linh Châu Chí , Khôi Hoàng Anh , Hà Nguyễn Thị Như 
Published: October 2021

Mục tiêu: đánh giá kết quả dài hạn của phẫu thuật bắc cầu động mạch vành (BCĐMV) đơn thuần sử dụng cả hai động mạch ngực trong (ĐMNT) làm toàn bộ cầu nối.
Phương pháp: nghiên cứu quan sát theo dõi dọc trên nhóm bệnh nhân (BN) được phẫu thuật BCĐMV đơn thuần chỉ bằng 2 ĐMNT trong giai đoạn 2008-2017 tại Viện Tim Thành phố HCM.
Kết quả: tổng số BN là 246 với tuổi trung bình: 61 ± 9,1 năm. Nam giới chiếm 72,3%. Đau ngực không ổn định trước mổ chiếm 72%. Chỉ số EuroScore II trung bình là 2,53. Tất cả BN đều có bệnh 3 thân chính ĐMV, 32% đi kèm hẹp thân chung > 50%. Số cầu nối trung bình cho một BN là 3,3 ± 0,55. Tử vong phẫu thuật 1,6% (4). Thời gian theo dõi trung bình là 65,9 ± 40,3 tháng. Tử vong muộn là 15 BN trong đó, 9/15 trường hợp tử vong liên quan đến tim mạch. Đau ngực tái phát đi kèm bằng chứng khi chụp mạch vành là 10. Có 4 BN cần tái can thiệp mạch vành sau mổ. Tỉ lệ sống còn sau 12 năm theo Kaplan-Meier cho toàn bộ BN là 89,1 ± 3,8%, tỉ lệ không bị can thiệp mạch vành trở lại là 87,8 ± 6,3%.
Kết luận: Phẫu thuật BCĐMV sử dụng cả hai ĐMNT làm toàn bộ cầu nối là an toàn, hiệu quả và cho kết quả về dài hạn rất tốt.