bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sebaran Kualitas Air Laut di Perairan Sekitar PLTU Teluk Sepang Kota Bengkulu Berdasarkan Parameter Fisika-Kimia
Authors: Lizalidiawati Lizalidiawati , Juniarti Erma , Harlianto Budi 
Published: June 2021

PLTU Teluk Sepang Bengkulu City produces heat waste dumped back into the sea which affects the quality of the water so that it has a negative impact on marine life. This study aimed to identify the quality of the water around PLTU Teluk Sepang Bengkulu City based on the physical and chemical parameters. The method used was direct measurement at the research location which is carried out at 12 measurement points,i.e 4 points around the outlet area, and 8 points in the off-shore area. The measurement result was compared with seawater quality standard for marine biota based on the Minister of Environment Decree No. 51 of 2004 and was validated by analysis of sea water quality before the PLTU had operated. The result showed that the some parameters met the quality standards for marine biota included DO of 5.62-7.82, pH and turbidity in the offshore area with each value of 7.24-7.86 and 1.68-4.846 NTU. Meanwhile, the parameters which did not meet quality standards include a temperature of 30.62-36 ºC, a salinity of 26.6-30 ‰, pH and turbidity around the outlet area with each value of 6.7-6.88 and 23.25-146.8 NTU. Based on the validation result, it showed that heat waste had a very significant effect on the physical and chemical parameters of the waters, especially on temperature, pH, and turbidity.
Determinação de selênio em leite bovino in natura provenientes do Ceará - Brasil
Authors: Assis Renata Carmo de , Nogueira Maria Dinara de Araújo , Pinheiro Alexandre Danton Viana , Galdino Ruth Silva , Almondes Kaluce Gonçalves de Sousa , Maia Carla Soraya Costa 
Published: June 2021

O selênio é essencial para a saúde humana. Dentre os alimentos considerados fonte de selênio, estão as castanhas brasileiras, carnes, ovos, leites e outros, variando conforme a área geográfica de plantio ou criação do animal. Dados de Se em alimentos cultivados, industrializados e comercializados no Brasil são ausentes em tabelas de composição de alimentos brasileiras. O objetivo do estudo foi determinar a concentração de selênio em leite bovino in natura produzido no Ceará, região Nordeste do Brasil. Trata-se de uma pesquisa experimental, onde as amostras foram coletadas em municípios das principais bacias leiteiras do Ceará. As concentrações de selênio foram determinadas por Espectrofotometria de Absorção Atômica por Geração de Hidretos acoplado a cela de quartzo. Os teores de umidade, cinzas e proteína foram analisados segundo a metodologia da Association of Official Analytical Chemists (1980), o teor de lipídios por método de Soxhlet e a quantidade de carboidratos foi calculada por diferença. A média das concentrações de selênio, umidade, cinza, proteína, lipídio e carboidrato do leite bovino in natura foi de 2.9 µg/100mL, 89.0 mg/100 mL, 0.6 mg/100mL, 2.9 mg/100mL, 3.6 mg/100mL e 4.0 mg/100mL, respectivamente. A concentração de selênio no leite bovino in natura variou de 0.1-9.0 µg/100ml, sendo em algumas localidades superior em relação a outras localidades do Brasil e do mundo, podendo contribuir para o consumo deste mineral pela população do estado.
Penerapan Strategi Marketting Mix Dalam Upaya Meningkatkan Penjualan Keripik Pisang Makasy di Kota Sorong
Authors: Inayah Nahda , Syam Yusrial , Rawi Rais Dera Pua , Zain Evi Mufrihah , Lestari Bekti Wiji , Wijiastuti Retno Dewi 
Published: June 2021

Pada umumnya masyarakat selalu menginginkan sesuatu yang berbeda, tidak terkecuali dengan hal kuliner atau makanan. Oleh karena itu dengan menciptakan Keripik Makasy ini konsumen bisa lebih tertarik, karena di kota sorong sendiri pengolahan pisang di buat seperti pisang nungget, pisang goreng keju, sudah sangat banyak. Jadi kami mengolah pisang menjadi sebuah keripik untuk menghadirkan varian baru dari makanan ringan sejenis.Olahan keripik pisang Makasy ini merupakan program kreativitas mahasiswa Universitas Muhammadiyah Sorong di Fakultas Ekonomi. Dan Keripik Pisang Makasy ini dibuat dengan tingkat higienis dan kebersihan yang tinggi serta tidak menggunakan bahan-bahan kimia yang dapat merusak kesehatan seperti borax, formalin, pewarna buatan ataupun bahan berbahaya yang lain.Pada pengolahan Keripik Pisang MakasyÂ ada beberapa bahan baku yang dibutuhkan seperti Pisang Mentah, kapur sirih,garam, air bersih. Dan keripikÂ Makay memiliki berbagai varian rasa yaitu: balado, BBQ, jagung manis, jagung bakar, dan pedas manis.
Polyphenol Enriched Diet Administration During Pregnancy and Lactation Prevents Dysbiosis in Ulcerative Colitis Predisposed Littermates
Authors: De Santis Stefania , Scarano Aurelia , Liso Marina , Calabrese Francesco Maria , Verna Giulio , Cavalcanti Elisabetta , Sila Annamaria , Lippolis Antonio , De Angelis Maria , Santino Angelo , Chieppa Marcello 
Published: June 2021

Neonatal colonization of the gastrointestinal tract depends on mother microbiome, thus mother microbiota dysbiosis is transmitted to the offspring during the delivery and shaped by breastmilk characteristics. Here we used a murine model of UC predisposition (Winnie-/-) to evaluate the effects of maternal diet during pregnancy and lactation. Using heterozygous breeders, we obtained both Winnie-/- and C57BL/6 littermates from the same mother and compared their microbiota at weaning and adult age, using a diet enriched with 1% tomato fruit of a line – named Bronze – highly enriched in bioactive polyphenols, or Control tomato. Females received enriched diets two weeks before the beginning of the breeding and never stopped for the following six months. No significant effect was observed in regard to the percentage of Winnie-/- offspring, as with both diets the percentage was about 25% as expected. Winnie littermates from breeders fed with the Bronze-enriched diet showed reduced dysbiosis at 4 weeks of age if compared with Winnie under the Control tomato diet. This effect was then reduced when mice reached adult age. Conversely, the microbiota of C57BL/6 does not change significantly, indicating that fortified mothers-diet significantly contribute to preventing dysbiosis in genetically predisposed offspring, but has mild effects on healthy littermates and adult mice. An overall tendency towards reduced inflammation was underlined by the colon weight and the percentage of Foxp3+ cells reduction in Winnie mice fed with Bronze diet. Control diet did not show similar tendency.
Post-Surgical Outcome and Its Determining Factors in Patients Operated on With Focal Cortical Dysplasia Type II—A Retrospective Monocenter Study
Authors: Rácz Attila , Becker Albert J. , Quesada Carlos M. , Borger Valeri , Vatter Hartmut , Surges Rainer , Elger Christian E. 
Published: June 2021

Purpose: Focal cortical dysplasias (FCDs) are a frequent cause of drug-resistant focal epilepsies. These lesions are in many cases amenable to epilepsy surgery. We examined 12-month and long-term post-surgical outcomes and its predictors including positive family history of epilepsy.Methods: Twelve-month and long-term outcomes regarding seizure control after epilepsy surgery in patients operated on with FCD type II between 2002 and 2019 in the Epilepsy Center of Bonn were evaluated based on patient records and telephone interviews.Results: Overall, 102 patients fulfilled the inclusion criteria. Seventy-one percent of patients at 12 months of follow-up (FU) and 54% of patients at the last available FU (63 ± 5.00 months, median 46.5 months) achieved complete seizure freedom (Engel class IA), and 84 and 69% of patients, respectively, displayed Engel class I outcome. From the examined variables [histopathology: FCD IIA vs. IIB, lobar lesion location: frontal vs. non-frontal, family history for epilepsy, focal to bilateral tonic–clonic seizures (FTBTCS) in case history, completeness of resection, age at epilepsy onset, age at surgery, duration of epilepsy], outcomes at 12 months were determined by interactions of age at onset, duration of epilepsy, age at surgery, extent of resection, and lesion location. Long-term post-surgical outcome was primarily influenced by the extent of resection and history of FTBTCS. Positive family history for epilepsy had a marginal influence on long-term outcomes only.Conclusion: Resective epilepsy surgery in patients with FCD II yields very good outcomes both at 12-month and long-term follow-ups. Complete lesion resection and the absence of FTBTCS prior to surgery are associated with a better outcome.
Genetic Polymorphisms in Enzymes Involved in One-Carbon Metabolism and Anti-epileptic Drug Monotherapy on Homocysteine Metabolism in Patients With Epilepsy
Authors: Zhu Shaofang , Ni Guanzhong , Sui Lisen , Zhao Yiran , Zhang Xiaoxu , Dai Qilin , Chen Aohan , Lin Wanrong , Li Yinchao , Huang Min , Zhou Liemin 
Published: June 2021

Aims: To investigate the effects of single nucleotide polymorphisms (SNPs) in genes of one-carbon metabolism (OCM) related enzymes and anti-epileptic drug (AED) monotherapy on homocysteine (Hcy) metabolism in patients with epilepsy, and to further explore specific SNPs that may increase patients' susceptibility to the effects of AEDs on the Hcy imbalance.Method: This case-control study analyzed 279 patients with epilepsy, including patients receiving monotherapy with valproate (VPA) (n = 53), oxcarbazepine (OXC) (n = 71), lamotrigine (LTG) (n = 55), or levetiracetam (LEV) (n = 35) and patients who had not taken any AEDs (controls, n = 65) for at least 6 months. Serum levels of vitamin B12 (vit B12), folate (FA) and Hcy were measured, and 23 SNPs in 13 genes of OCM-related enzymes were genotyped in all patients.Results: Methylenetetrahydrofolate reductase (MTHFR) rs1801133 was associated with elevated serum Hcy levels in patients with epilepsy (P &lt; 0.001), and patients presenting the TT genotype exhibited higher serum Hcy levels than patients with the CC (P &lt; 0.001) or CT (P &lt; 0.001) genotype. A subsequent multiple linear regression analysis showed that AED monotherapy with VPA (vs. control: P = 0.023) or OXC (vs. control: P = 0.041), and genotypes of MTHFR rs1801133 TT (vs. CC: P &lt; 0.001; vs. CT: P &lt; 0.001), transcobalamin 2 (TCN2) rs1801198 CC (vs. GC: P = 0.039) and folate receptor 1 (FOLR1) rs2071010 AA (vs. GA: P = 0.031) were independent risk factors for higher Hcy levels. In the subgroup analysis of patients taking OXC, we found that patients with genotypes of MTHFR rs1801133 TT (vs. CC: P = 0.001; vs. CT: P &lt; 0.001) and TCN2 rs1801198 CC (vs. GC: P = 0.021; vs. GG: P = 0.018) exhibited higher serum Hcy levels.Conclusions: VPA, OXC, and genotypes of MTHFR rs1801133 TT, TCN2 rs1801198 CC, and FOLR1 rs2071010 AA are all independent risk factors for elevated Hcy levels in patients with epilepsy. Moreover, genotypes of MTHFR rs1801133 TT and TCN2 rs1801198 CC may increase patients' susceptibility to the effect of OXC on disrupting Hcy homeostasis.
Scaling Up the Family Integrated Care Model in a Level IIIC Neonatal Intensive Care Unit: A Systematic Approach to the Methods and Effort Taken for Implementation
Authors: Moreno-Sanz Bárbara , Montes María Teresa , Antón Marta , Serrada María Teresa , Cabrera Marta , Pellicer Adelina 
Published: June 2021

Background: Family Integrated Care (FICare) integrates parents in the direct care of their child while the healthcare personnel act as teachers and guides. To this date, most reports on the feasibility of this model refer to stable preterm infants admitted to Neonatal Intensive Care Units (NICUs).Objectives: To scale up and adapt FICare to make it suitable in level IIIC NICUs, which care for extreme prematurity and other complex medical or surgical neonatal conditions.Materials and Methods: Step 1 was the creation of the FICare implementation team (FICare-IT) and baseline analysis of current procedures for critical care to identify needs, wishes, and requirements; we aimed for protocol elaboration tailored to our cultural, architectural, and clinical context (March 2017 to April 2018). Step 2 as a dissemination strategy by FICare-IT acting as primary trainers and mentors to ensure the education of 90% of nursing staff (May 2018 to July 2018). Step 3 involved piloting and evaluation with the aim to refine the procedure (July 2018 to December 2020).Results: A rigorous but flexible protocol was edited. The FICare educational manual included two curricula: for healthcare professionals/staff (Training the trainers) and for families (Education of caregivers), the latter being categorized in two intervention levels (basic and advanced), depending on the infant care needs and parent's decision. In total, 76 families and 91 infants (74.7% preterm; 18.7% complex surgery; 6.6% others) were enrolled in the pilot. No differences in acceptance rate (overall 86.4%) or in the number of infant-family dyads in the program per month were observed when considering the pre- and post-Covid-19 pandemic periods. All families, except for one who dropped out of the program, completed the agreed individualized training. Mothers spent more time in NICU than fathers (p &lt; 0.05); uninterrupted time spent by mothers in NICU was longer during the pre-pandemic period (p &lt; 0.01). Observed time to reach proficiency by task was within the expected time in 70% of the program contents. The parents revealed educational manuals, workshops, and cot-side teaching sessions as essential for their training, and 100% said they would accept entry into the FICare program again.Conclusions: The principles of the FICare model are suitable for all levels of care in NICUs. Leadership and continuous evaluation/refinement of implementation procedures are essential components to achieve the objectives.
Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications
Authors: Wolking Stefan , Campbell Ciarán , Stapleton Caragh , McCormack Mark , Delanty Norman , Depondt Chantal , Johnson Michael R. , Koeleman Bobby P. C. , Krause Roland , Kunz Wolfram S. , Marson Anthony G. , Sander Josemir W. , Sills Graeme J. , Striano Pasquale , Zara Federico , Sisodiya Sanjay M. , Cavalleri Gianpiero L. , Lerche Holger ,   EpiPGX Consortium
Published: June 2021

Objective: Resistance to anti-seizure medications (ASMs) presents a significant hurdle in the treatment of people with epilepsy. Genetic markers for resistance to individual ASMs could support clinicians to make better-informed choices for their patients. In this study, we aimed to elucidate whether the response to individual ASMs was associated with common genetic variation.Methods: A cohort of 3,649 individuals of European descent with epilepsy was deeply phenotyped and underwent single nucleotide polymorphism (SNP)-genotyping. We conducted genome-wide association analyses (GWASs) on responders to specific ASMs or groups of functionally related ASMs, using non-responders as controls. We performed a polygenic risk score (PRS) analyses based on risk variants for epilepsy and neuropsychiatric disorders and ASM resistance itself to delineate the polygenic burden of ASM-specific drug resistance.Results: We identified several potential regions of interest but did not detect genome-wide significant loci for ASM-specific response. We did not find polygenic risk for epilepsy, neuropsychiatric disorders, and drug-resistance associated with drug response to specific ASMs or mechanistically related groups of ASMs.Significance: This study could not ascertain the predictive value of common genetic variants for ASM responder status. The identified suggestive loci will need replication in future studies of a larger scale.
What's Behind Image? Toward a Better Understanding of Image-Driven Behavior
Authors: Regner Tobias 
Published: June 2021

Our experimental design systematically varies image concerns in a dictator/trust game. In comparison to the baseline, we either decrease the role of self-image concerns (by providing an excuse for selfish behavior) or increase the role of social-image concerns (by conveying the transfer choice to a third person). In this set up, we analyze the underlying processes that motivate subjects to give less/more. Controlling for distributional preferences and expectations, our results indicate that moral emotions (guilt and shame) are a significant determinant of pro-social behavior. The disposition to guilt explains giving in the baseline, while it does not when an excuse for selfish behavior exists. Subjects' disposition to shame is correlated to giving when their choice is public and they can be identified.JEL Classifications:C72, C91, D03, D80
Culture-Related Health Disparities in Quality of Life: Assessment of Instrument Dimensions Among Chinese
Authors: Li Minghui , Bao Zhang , Lv Gang , Zhou Jianying , Chen Pingyu , Luo Nan 
Published: June 2021

Background: Health-related quality of life (HRQoL) is one of the major focuses of primary care. However, HRQoL instruments used in China are mainly developed from Western countries. Such instruments may not cover all important health concepts valued by the Chinese as health is a culture-specific concept.Objectives: The objectives of this study are to identify culture-specific health dimensions and culture-related health disparities in primary care that are considered important by Chinese living in China.Methods: A purposive sample of 164 adult Chinese (67 healthy persons and 97 patients) were interviewed face to face. In-depth open-ended questions were asked to elicit culture-specific dimensions of quality of life in primary care settings in China.Results: Twelve health dimensions were identified. Five most frequently mentioned dimensions were: mood (N = 52, 31.71%), physical activities (N = 48, 29.27%), work (N = 40, 24.39%), diet (N = 32, 19.51%), and vitality (N = 28, 17.07%). Significantly more healthy persons reported mood (49.25 vs. 19.59%, P &lt; 0.001), mindset (16.42 vs. 0.00%, P &lt; 0.001), and self-care (11.94 vs. 2.06%, P = 0.016) characterizing good HRQoL, while more patients emphasized on work (4.48 vs. 38.14%, P &lt; 0.001). Diet and vitality appeared to be culture-specific dimensions related to health among Chinese.Conclusions: To better adapt or develop HRQoL instruments for Chinese, dimensions or items regarding diet might be included and disparities in the meaning of vitality between Chinese and Western cultures should be considered.
The Application of a System of Eye Tracking in Laparoscopic Surgery: A New Didactic Tool to Visual Instructions
Authors: Marín-Conesa Ester , Sánchez-Ferrer Francisco , Grima-Murcia María Dolores , Sánchez-Ferrer María Luisa 
Published: June 2021

Introduction: Laparoscopic surgery is an increasingly used technique, but it requires a high degree of learning, and communication between the operating room crew is considerably difficult. The use of eye tracking has been proposed as a didactic and evaluation tool in several settings, including in laparoscopy in simulators.Objectives: This study aimed to evaluate the usefulness of the use of eye tracking systems (Tobii glasses 2) in laparoscopic surgery as a didactic and assessment tool to improve communication in the operating room and improve patients' security.Methodology: An anonymous survey was sent to the students and medical teachers of a faculty of medicine and practicing doctors and residents. The message contained an explanation about the use of the Tobii glasses, a link to watch the video showing its use in a laparoscopic surgery, and the survey to complete after watching the video.Results: The survey was answered by 113 participants (51.3% medical students, 27.4% medical teachers, 18.6% practicing doctors, and 2.7% medicine residents). Eighty-three percent agreed with the usefulness of the “Tobii glasses” in the operating room for improving communication between the main surgeon and the assistant, for learning complex surgery techniques, for obtaining didactic videos, and for indicating anatomical structures. The item scored worst was the price of the glasses.Conclusions: It is possible to record and project expert gaze patterns in the operating room in real time using the Tobii glasses. This device allows improving communication among the surgical crew and the learning of residents and also improving the security of surgical patients.
Case Report: Modified Thoracoscopic-Assisted Cervical Resection for Retrosternal Goiter
Authors: Nesti Cédric , Wohlfarth Benny , Borbély Yves M. , Kaderli Reto M. 
Published: June 2021

Introduction: The treatment of choice for retrosternal goiters (RSG) is surgical resection to relieve symptoms and rule out malignancy. Although the majority of RSG can be removed by a cervical approach only, an extracervical approach (e.g., sternotomy, thoracotomy or thoracoscopy) may be required. Herein, we describe a refined thoracoscopic-assisted cervical two-team RSG resection without thoracoscopic mediastinal dissection.Technique: A 57-year-old man presented with a large RSG with posterior mediastinal extension (PME) and extensive peritumoral vascularization. Due to its extension below the aortic arch and its small connection with the right thyroid lobe, a combined cervical and thoracoscopic approach was intended. The endocrine surgery unit performed the cervical mobilization of the right thyroid lobe, while the thoracic surgery unit gently pushed the mediastinal tumor through the thoracic inlet without performing mediastinal dissection. This allowed a safe visualization of the inserting vessels by the endocrine surgery team at the neck, followed by a stepwise division of the vessels and resection of the retrosternal nodule through the cervical access.Comment: The described approach is indicated for RSG with posterior mediastinal extension, anteroposterior dimension smaller than the thoracic inlet and inaccessibility from a cervical approach only. This minimally invasive approach is associated with a faster recovery, decreased morbidity and postoperative pain, shorter hospital stay and better cosmetic results.
Using Citizen Science to Scout Honey Bee Colonies That Naturally Survive Varroa destructor Infestations
Authors: Moro Arrigo , Beaurepaire Alexis , Dall’Olio Raffaele , Rogenstein Steve , Blacquière Tjeerd , Dahle Bjørn , de Miranda Joachim R. , Dietemann Vincent , Locke Barbara , Licón Luna Rosa María , Le Conte Yves , Neumann Peter 
Published: June 2021

Citizen Science contributes significantly to the conservation of biodiversity, but its application to honey bee research has remained minimal. Even though certain European honey bee (Apis mellifera) populations are known to naturally survive Varroa destructor infestations, it is unclear how widespread or common such populations are. Such colonies are highly valuable for investigating the mechanisms enabling colony survival, as well as for tracking the conservation status of free-living honey bees. Here, we use targeted Citizen Science to identify potentially new cases of managed or free-living A. mellifera populations that survive V. destructor without mite control strategies. In 2018, a survey containing 20 questions was developed, translated into 13 languages, and promoted at beekeeping conferences and online. After three years, 305 reports were collected from 28 countries: 241 from managed colonies and 64 from free-living colonies. The collected data suggest that there could be twice as many naturally surviving colonies worldwide than are currently known. Further, online and personal promotion seem to be key for successful recruitment of participants. Although the survivor status of these colonies still needs to be confirmed, the volume of reports and responses already illustrate how effectively Citizen Science can contribute to bee research by massively increasing generated data, broadening opportunities for comparative research, and fostering collaboration between scientists, beekeepers, and citizens. The success of this survey spurred the development of a more advanced Citizen Science platform, Honey Bee Watch, that will enable a more accurate reporting, confirmation, and monitoring of surviving colonies, and strengthen the ties between science, stakeholders, and citizens to foster the protection of both free-living and managed honey bees.