bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actin gamma 1 is a critical regulator of pancreatic ductal adenocarcinoma
Authors: Tang Yichen , Peng Xuehui , Huang Xiaobing , Li Jing 
Published: December 2021

Background:
Pancreatic ductal adenocarcinoma (PDAC) accounts for about 90% of pancreatic cancers, which represents one of the most lethal malignancies with a 5-year overall survival less than 10%. Identifying molecular biomarkers is invaluable in helping to predict clinical outcomes and developing targeted chemotherapies. Actin gamma 1 (ACTG1) is a kind of actin isoform that exists in almost all cell types as a component of the cytoskeleton, thus mediating cell viability. Although there have been studies revealing the prognostic significance of ACTG1 in several malignancies such as glioblastoma and hepatocellular carcinoma, its involvement and function in pancreatic cancer needs to be elucidated.

Methods:
We retrospectively enrolled a cohort of PDAC patients after surgical resection (n = 149) and conducted immunohistochemistry experiments to explore the expression profile of ACTG1. Univariate and multivariate analyses were performed to investigate the clinical relevance of ACTG1. The functional role of ACTG1 in PDAC progression was further validated via both in vitro and in vivo studies.

Results:
ACTG1 presented a higher expression in PDAC tissues than in nontumorous pancreatic tissues. ACTG1 level positively correlated with tumor stage, implying its potential role as a tumor promoter. Univariate and multivariate analyses identified that patients with lower ACTG1 showed a better overall survival compared to those with higher ACTG1 expression. Cellular and xenograft experiments confirmed the role of ACTG1 on facilitating tumor proliferation both in vitro and in vivo.

Conclusions:
Our study revealed a pro-oncogenic role of ACTG1 in PDAC, which may help predict prognosis and serve as a novel therapeutic target.
Clima organizacional y su impacto en la calidad educativa universitaria
Authors: Martínez Prats Germán , Mapén Franco Fabiola de Jesús , Ortega Ramírez Marynor Elena 
Published: December 2021

El compromiso social de las instituciones de educación superior de contribuir al desarrollo y bienestar de las sociedades lo cumple a través del perfil académico de sus egresados, lo cual implica la puesta en marcha de múltiples actividades inherentes a sus funciones sustantivas como la docencia e investigación pero también otras encaminadas a la evaluación a través de sus indicadores. Sin embargo, se reconoce que existen factores psicológicos y sociológicos que inciden en el comportamiento de los diversos agentes universitarios con la respectiva repercusión en la calidad educativa. Por ello, el objetivo de la presente investigación fue evaluar el clima organizacional en la Escuela Maya de Estudios Agropecuarios de la Universidad Autónoma de Chiapas en México y su impacto en el Sistema de Gestión de Calidad Institucional. La muestra para sustentar el estudio fue de 111 actores educativos. El enfoque de la investigación fue mixto y la validez de los instrumentos se realizó a través del Coeficiente Alfa de Cronbach cuyos resultados en las dimensiones de análisis oscilaron entre 0.898 y 0.95. Los resultados reflejaron que los factores que afectan en mayor proporción el clima organizacional son: el confort, la motivación, identidad, comunicación, estructura, toma de decisiones, liderazgo, recompensa, innovación y cooperación en la solución de conflictos. El 24% considera que su contribución y labor de desempeño es valorada por todos los agentes educativos, mientras que el 48% considera que sus directivos carecen de capacidades gerenciales.
Development of HFU-based permeability prediction models using core data for characterisation of a heterogeneous Oligocene sand in the Nam Con Son basin
Authors: Nguyễn Văn Hiếu , Nguyễn Hồng Minh , Phan Ngọc Quốc , Phạm Huy Giao 
Published: December 2021

Core data by both routine and special core analysis are required to understand and predict reservoir petrophysical characteristics. In this research, a total number of 50 core plugs taken from an Oligocene sand (T30) in the Nam Con Son basin, offshore southern Vietnam, were tested in the core laboratory of the Vietnam Petroleum Institute (VPI).
The results of routine core analysis (RCA) including porosity and permeability measurements were employed to divide the study reservoir into hydraulic flow units (HFUs) using the global hydraulic elements (GHEs) approach. Based on five classified HFUs, 16 samples were selected for special core analysis, i.e., mercury injection capillary pressure (MICP) and grain size analyses for establishing non-linear porosity-permeability model of each HFU based on Kozeny-Carman equation, which provides an improved prediction of permeability (R2 = 0.846) comparing to that by the empirical poro-perm relationship (R2 = 0.633).
In addition, another permeability model, namely the Winland R35 method, was applied and gave very satisfactory results (R2 = 0.919). Finally, by integrating the results from MICP and grain size analyses, a good trendline of pore size distribution index (λ) and grain sorting was successfully obtained to help characterise the study reservoir. High λ came with poor sorting, and vice versa, the low λ corresponded to good sorting of grain size.
Janelle Monáe’s The ArchAndroid
Authors: Favreau Alyssa 
Published: December 2021

In Janelle Monáe’s full-length debut, the science fiction concept album The ArchAndroid, the android Cindi Mayweather is on the run from the authorities for the crime of loving a human. Living in 28th century Metropolis, Cindi fights for survival, soon realizing that she is in fact the prophesied ArchAndroid, a robot messiah meant to liberate the masses and lead them toward a wonderland where all can be free.
Taking into account the literary merit of Monáe’s astounding multimedia body of work, the political relevance of the science fictional themes and aesthetics she explores, and her role as an Atlanta-based pop cultural juggernaut, this book explores the lavish world building of Cindi’s story, and the many literary, cinematic, and musical influences brought together to create it. Throughout, a history of Monáe’s move to Atlanta, her signing with Bad Boy Records, and the trials of developing a full-length concept album in an industry devoted to the production of marketable singles can be found, charting the artist’s own rise to power. The stories of Monáe and of Cindi are inextricably entwined, each making the other more compelling, fantastical, and deeply felt.
PRÁTICAS ARQUEOLÓGICAS EM COMUNIDADE: Experiências Participativas na Chapada Diamantina, no Âmbito do Projeto Circuitos Arqueológicos de Visitação
Authors: Etchevarne Carlos Alberto , Bezerra Alvandyr Dantas 
Published: December 2021

As práticas sociais desenvolvidas no âmbito do “Projeto Circuitos Arqueológicos de Visitação da Chapada Diamantina/Bahia” enquadram-se nos pressupostos da chamada Arqueologia Pública. Os resultados da vivência efetivada nos seis municípios chapadenses contemplados (Iraquara, Lençóis, Morro do Chapéu, Palmeiras, Seabra e Wagner), deixam transparecer a importância do compromisso social quando a prática arqueológica é desenvolvida em contextos comunitários, nesse caso, em localidades situadas próximas aos sítios de arte rupestre. Trata-se, por conseguinte, de uma reflexão sobre a natureza transformadora da Arqueologia através da interação social e troca de saberes. ARCHAEOLOGICAL PRACTICES IN THE COMMUNITY: Participative Experiences in the Diamantine Plate, in the Framework of the Archaeological Visitation Circuits ProjectABSTRACTThe social practices developed within the scope of the “Chapada Diamantina / Bahia Archaeological Visitation Project” fit the premises of the so-called Public Archeology. The results of the experience carried out in the six contemplated Chapada municipalities (Iraquara, Lençóis, Morro do Chapéu, Palmeiras, Seabra and Wagner), reveal the importance of social commitment when the archaeological practice is developed in community contexts, in this case, in locations located close by to rock art sites. It is, therefore, a reflection on the transformative nature of Archeology through social interaction and exchange of knowledge.Keywords: Archaeological circuits; Rock Arte; Community Archeology.
Gedikpaşalı Yahyâ Nazîm Efendi’nin Hayatı ve Eserleri
Authors: ŞENDURAN Fatma Münevver 
Published: December 2021

Bu çalışmanın amacı; 17. yüzyılda yaşayan Gedikpaşalı Yahyâ Nazîm Efendi’nin şâirlik ve bestekârlık yönlerini irdeleyerek, Türk Mûsıkîsi’ndeki yerini ve önemini ortaya koymaktır. Günümüzde güfteleri ve besteleri sık kullanılmamasına rağmen kendi dönemine damgasını vurmuş, hem Türk Mûsıkîsi hem de Türk Edebiyâtı alanlarına önemli katkılar sağlamıştır. Şâir Neşâtî tarafından kendisine “Nazîm” mahlası verilen ve aynı zamanda sesinin güzelliği ile yaşadığı dönemde adından sıklıkla bahsolunan Yahyâ Nazîm Efendi; dönemin ünlü hânendeleri arasında yer almış, kendine has icrâsı ile pâdişâh huzurunda birçok fasılda bulunmuştur.
Kendi zamanında yaşamış olan mühim bestekârlara, yazdığı şiirler ilham olmuş ve Peygamber Efendimiz için kaleme aldığı naatlar ile takdir görerek büyük beğeni kazanmıştır. Yahyâ Nazîm Efendi’nin kaleme almış olduğu şiirlere dönemin birçok bestekârı da rağbet etmiştir.
Çalışmamızda Yahyâ Nazîm Efendi’nin repertuvarımızda yer alan besteleri ve güfteleri tablolar hâlinde verilerek değerlendirilmiştir. Ayrıca elde edilen bulgular doğrultusunda; Yahyâ Nazîm Efendi’nin hayatı, yazmış olduğu “Dîvân-ı Belâgat-unvân-ı Nazîm” adlı eserin Türk Mûsıkîsi açısından incelenmesi, eserlerinin hangi bestekârlar ve güftekârlar tarafından tercih edildiğine yer verilerek Türk Mûsıkîsi’ndeki yeri ve önemi somutlaştırılmaya çalışılacaktır.
Nitel bir inceleme olan araştırmada betimsel araştırma yöntemi kullanılmıştır. Bestelerin form analizleri Serda Türkel Oter tarafından geliştirilen, güftenin temel alındığı biçim analiz yöntemi ile yapılmıştır. Yahyâ Nazîm Efendi’nin repertuvarımızda yer alan bestelerinin biçim şemaları hazırlanarak, güfteler dîvânda yer alan yazımları ile karşılaştırılmış, gerekli tahlillerin ardından değerlendirilerek tablolar hâlinde biçim şemalarına yer verilmiştir.
Holocene vegetation transitions and their climatic drivers in MPI-ESM1.2
Authors: Dallmeyer Anne , Claussen Martin , Lorenz Stephan J. , Sigl Michael , Toohey Matthew , Herzschuh Ulrike 
Published: December 2021

Abstract. We present a transient simulation of global vegetation and climate patterns
of the mid- and late Holocene using the MPI-ESM (Max Planck Institute for
Meteorology Earth System Model) at T63 resolution. The simulated vegetation
trend is discussed in the context of the simulated Holocene climate change.
Our model captures the main trends found in reconstructions. Most prominent
are the southward retreat of the northern treeline that is combined with the strong decrease of forest in the high northern latitudes during the Holocene
and the vast increase of the Saharan desert, embedded in a general decrease
in precipitation and vegetation in the Northern Hemisphere monsoon margin
regions. The Southern Hemisphere experiences weaker changes in total
vegetation cover during the last 8000 years. However, the monsoon-related
increase in precipitation and the insolation-induced cooling of the winter
climate lead to shifts in the vegetation composition, mainly between the
woody plant functional types (PFTs). The large-scale global patterns of vegetation almost linearly follow the
subtle, approximately linear, orbital forcing. In some regions, however,
non-linear, more rapid changes in vegetation are found in the simulation.
The most striking region is the Sahel–Sahara domain with rapid vegetation
transitions to a rather desertic state, despite a gradual insolation
forcing. Rapid shifts in the simulated vegetation also occur in the high
northern latitudes, in South Asia and in the monsoon margins of the Southern Hemisphere. These rapid changes are mainly triggered by changes in the
winter temperatures, which go into, or move out of, the bioclimatic
tolerance range of individual PFTs. The dynamics of
the transitions are determined by dynamics of the net primary production
(NPP) and the competition between PFTs. These changes mainly occur on
timescales of centuries. More rapid changes in PFTs that occur within a few
decades are mainly associated with the timescales of mortality and the
bioclimatic thresholds implicit in the dynamic vegetation model, which have
to be interpreted with caution. Most of the simulated Holocene vegetation changes outside the high northern
latitudes are associated with modifications in the intensity of the global
summer monsoon dynamics that also affect the circulation in the extra
tropics via teleconnections. Based on our simulations, we thus identify the
global monsoons as the key player in Holocene climate and vegetation change.
Modeling seasonal variations of extreme rainfall on different timescales in Germany
Authors: Ulrich Jana , Fauer Felix S. , Rust Henning W. 
Published: December 2021

Abstract. We model monthly precipitation maxima at 132 stations in Germany for a wide range of durations from 1 min to about 6 d using a duration-dependent generalized extreme value (d-GEV) distribution with monthly varying parameters. This allows for the estimation of both monthly and annual intensity–duration–frequency (IDF) curves: (1) the monthly IDF curves of the summer months exhibit a more rapid decrease of intensity with duration, as well as higher intensities for short durations than the IDF curves for the remaining months of the year. Thus, when short convective extreme events occur, they are very likely to occur in summer everywhere in Germany. In contrast, extreme events with a duration of several hours up to about 1 d are conditionally more likely to occur within a longer period or even spread throughout the whole year, depending on the station. There are major differences within Germany with respect to the months in which long-lasting stratiform extreme events are more likely to occur. At some stations the IDF curves (for a given quantile) for different months intersect. The meteorological interpretation of this intersection is that the season in which a certain extreme event is most likely to occur shifts from summer towards autumn or winter for longer durations. (2) We compare the annual IDF curves resulting from the monthly model with those estimated conventionally, that is, based on modeling annual maxima. We find that adding information in the form of smooth variations during the year leads to a considerable reduction of uncertainties. We additionally observe that at some stations, the annual IDF curves obtained by modeling monthly maxima deviate from the assumption of scale invariance, resulting in a flattening in the slope of the IDF curves for long durations.
Accuracy of Meningitis Bacterial Score (MBS) as an indicator in establishing the diagnosis of acute bacterial meningitis in adults
Authors: Palupi Imas R. , Sugianto Paulus 
Published: December 2021

Bacterial meningitis persists as a worldwide threat contributing to high mortality and morbidity rate, where differentiating bacterial meningitis from aseptic meningitis is key for better management and outcomes. Hence, this study aimed to assess the Bacterial Meningeal Score (BMS) as a tool for early diagnosis of acute bacterial meningitis. This study employed a retrospective cross-sectional method using medical records of patients with meningitis and meningoencephalitis who were hospitalized at Dr. Soetomo Hospital, from January 2018 to September 2021. Data of demographics, clinical, laboratory and cerebrospinal fluid (CSF) profile and culture were collected. The diagnostic performance of the BMS in diagnosing acute bacterial meningitis was evaluated by its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR +) and negative likelihood ratio (LR -). A total of 128 patients who had been diagnosed with meningitis and meningoencephalitis were included. Out of total patients, 53 samples were diagnosed with acute bacterial meningitis as confirmed by CSF culture. The sensitivity and specificity of BMS with cutoff >2.5 in diagnosing acute bacterial meningitis were 92.4% and 92.0%, respectively with PPV 89.1% and NPV 94.5%. The area under the curve (AUC) of BMS in diagnosing of acute bacterial meningitis was 95.6% (95%CI: 92.3%, 99%). A BMS score of greater than 2.5 indicates a high likelihood of acute bacterial meningitis, whereas a score less than 2.5 indicates a low likelihood.
Hardware and projective research techniques in neuroeducation: issues and perspectives in application
Authors: Абабкова М.Ю. , Розова Н.К. 
Published: December 2021

Цифровая трансформация и переход от компетентностного к метапредметному подходу в обучении требуют освоения новых объективных исследовательских методов в образовании. Когнитивные исследования, в том числе использующие высокотехнологичные методики и нейротехнологии, повышают исследовательский и учебный потенциал образовательной организации.Digital transformation and the transition from a competence-based to a meta-subject approach in education require the development of new objective research techniques in education. Cognitive research done with high-tech techniques and neurotechnologies contributes to the research and educational capacity of an educational organization.
Perbincangan Sosialisasi Kebijakan Pendidikan Islam
Authors: Namora Dian , Bakar Abu 
Published: December 2021

The purpose of writing this article is to examine the approach to the formulation of education policy problems, the stages of policy formulation and the formulation of education policies, actors in the formulation of education policies and must be able to socialize education policies and education policy socialization strategies through the socialization media of education policy. This method of writing uses the methodology of the study of literature. The writing of this article is done by reviewing several journals related to education policy contained in the google scholar data base. The results of the study are then spelled out through scientific articles. To complete the Discussion of Socialization of Islamic Education Policy, education organizers must be able to know the framework of education policy development. Namely by contributing and approaching the formulation of education policy problems, the stage of formulation of policy problems and the formulation of education policies, actors in the formulation of education policies and must be able to do the stage of socialization of education policy at the preparatory stage, the stage of mimicking (play stage), and the stage of action (game stage), and able to conduct educational policy socialization strategies through the medium of socialization of policy. education.Tujuan penulisan artikel ini adalah untuk mengkaji pendekatan terhadap perumusan masalah kebijakan pendidikan, tahapan perumusan masalah kebijakan dan perumusan kebijakan pendidikan, aktor dalam perumusan kebijakan pendidikan serta harus mampu melakukan sosialisasi kebijakan pendidikan dan strategi sosialisasi kebijakan pendidikan melalui media sosialisasai kebijakan pendidikan. Metode penulisan ini menggunakan metodologi studi kepustakan. Penulisan artikel ini dilakukan dengan mengkaji beberapa journal yang berhubungan dengan kebijakan pendidikan yang terdapat pada data base google scholar. Hasil dari pengkajian kemudian dijabarkan melalui artikel ilmiah. Untuk menyelesaikan Perbincangan Sosialisasi Kebijakan Pendidikan Islam maka penyelenggara pendidikan harus mampu mengetahui kerangka kerja pengembangan kebijakan pendidikan. Yaitu dengan mengkontribusikan dan melakukan pendekatan terhadap perumusan masalah kebijakan pendidikan, tahapan perumusan masalah kebijakan dan perumusan kebijakan pendidikan, aktor dalam perumusan kebijakan pendidikan serta harus mampu melakukan tahapan sosialisasi kebijakan pendidikan pada tahap persiapan (preparatory stage), tahap meniru (play stage), dan tahap tindakan (game stage), serta mampu melakukan strategi sosialisasi kebijakan pendidikan melalui media sosialisasai kebijakan pendidikan.
PENERAPAN ETIKA KONSERVASI DALAM RESTORASI MINIATUR RUMAH TRADISIONAL NIAS: MELESTARIKAN ARSITEKTUR TRADISIONAL TAHAN GEMPA
Authors: Lestari Dian Novita , Hasanah Farah Dhita 
Published: December 2021

Indonesia memiliki arsitektur rumah tradisional yang sangat beragam. Namun, keberadaan bangunan tradisional Indonesia sudah semakin berkurang karena tergerus modernisasi. Salah satu upaya pelestarian yang dilakukan oleh Museum Nasional Indonesia adalah dengan mempertahankan bentuk arsitektur tradisional dalam bentuk miniatur koleksi. Miniatur ini memiliki fungsi sebagai representasi dari rumah asli di daerah asalnya. Dalam tulisan ini dijabarkan proses restorasi dua koleksi miniatur rumah tradisional yang terdapat di Museum Nasional, yaitu rumah tradisional Nias Utara dan Nias Selatan. Tahapan restorasi yang dilakukan mengikuti etika konservasi sehingga fisik koleksi dapat dipertahankan tanpa mengubah struktur asli bangunan yang seharusnya ada. Pelaksanaan restorasi diawali dengan mengumpulkan informasi mengenai bentuk koleksi sebelum kerusakan melalui pencarian data berupa foto, laporan kurasi, atau konservasi terdahulu. Informasi mengenai struktur dan material bangunan diperkuat dengan pencarian referensi yang sesuai. Restorasi miniatur rumah tradisional di Museum Nasional bertujuan untuk mengembalikan bentuk fisik bangunan arsitektur tradisional guna melestarikan fungsi-fungsi yang melekat padanya, seperti informasi mengenai keunikan arsitekturnya dan struktur tahan gempa. Tulisan ini diharapkan dapat menjadi acuan dalam penerapan etika konservasi yang harus dipatuhi dalam melakukan restorasi, khususnya dalam preservasi arsitektur tradisional.
Pengaruh persepsi siswa tentang pengelolaan kelas dan motivasi belajar terhadap prestasi belajar ekonomi siswa kelas xi jurusan akuntansi smk negeri 1 medan t.a 2017/2018
Authors: Fitrida Purba Ayu , Sinaga Dearlina , Simatupang Sopar 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh persepsi siswa tentang pengelolaan kelas terhadap prestasi belajar ekonomi siswa kelas XI SMKNegeri 1 Medan tahun ajaran 2017/2018, (2) pengaruh motivasi belajar terhadap prestasi belajar ekonomi siswa kelas XI SMK Negeri 1 Medan tahun ajaran 2017/2018, (3) pengaruh persepsi siswa tentang pengelolaan kelas dan motivasi belajar terhadap prestasi belajar ekonomi siswa kelas XI SMK Negeri 1 Medan tahun ajaran 2016/2017. Penelitian ini merupakan penelitian dengan pendekatan kuantitatif. Populasi penelitian ini adalah siswa kelas XI SMK Negeri 1 Medan sejumlah 149. Sebanyak 10 siswa digunakan untuk pengujian validitas angket, sedangkan 36 responden sebagai data penelitian. Teknik pengumpulan data menggunakan angket dengan model skala likert 4 alternatif jawaban. Analisis data yang digunakan adalah regresi linear berganda. Hasil penelitian menunjukkan: (1) terdapat pengaruh positif persepsi siswa tentang pengelolaan kelas terhadap prestasi belajar ekonomi siswa kelas XI SMK Negeri 1 Medan tahun ajaran 2017/2018; sebesar 3,628 (2) terdapat pengaruh positif motivasi belajar terhadap prestasi belajar ekonomi siswa kelas XI SMK Negeri 1 Medan tahun ajaran 2017/2018; 2,371 (3) terdapat pengaruh positif persepsi siswa tentang pengelolaan kelas dan motivasi belajar secara bersama-sama terhadap prestasi belajar ekonomi siswa kelas XI SMK Negeri 1 Medan tahun ajaran 2017/2018 dan sebesar 42,3 %.