bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can prolong life with nine turn method (Yan Nian Jiu Zhuan) Qigong alleviates Fatigue, Sleep quality, Depression and anxiety on Patients with Chronic Fatigue Syndrome: a Randomized, Controlled, Clinical Study ?
Authors: Xie Fangfang , Xu Jiatuo , Guan Chong , Cheng Ziji , Gu Yuanjia , Chen Ziying , Xie Chaoqun , Wang Jue , Shi Yuling , Ma XuXiang , Jiang Tao , Yao Fei , You Yanli 
Published: October 2021

Abstract
Background

Chronic fatigue syndrome (CFS) is a complex disease with unknown etiology and mechanism. Prolong life with nine turn method (PLWNT) Qigong is a system of mind-body exercise with restorative benefits that have shown a wide range of benefits in the treatment of CFS. The purpose of this study is to investigate the effect of PLWNT Qigong exercise on CFS with a focus on fatigue, sleep quality, depression and anxiety.
Methods

A total of 135 participants were randomly divided into treatment groups and control group in the same proportion. The treatment groups received PLWNT Qigong exercise (PLWNT Group) or cognitive behavioral therapy treatment (CBT Group). The healthy control group (HC Group) does not receive any treatment and maintains daily life. Participants from treatment groups were taught by related highly qualified professor at the Shanghai University of Traditional Chinese Medicine once a week and were supervised online during the remaining 6 days at home, over 12 consecutive weeks. The primary outcome was fatigue (MFI-20) and secondary outcomes were sleep quality (PSQI), anxiety and depression (HADS). All groups were measured at baseline (T0) and post-intervention (T1).
Results

134 patient completed the study (45 in the PLWNT Group, 44 in the CBT Group and 45 in HC Group). The within group comparison of PLWNT and CBT groups were all showed significant improvement in MFI-20, PSQI and HADS after the intervention (p༜0.05). No significant difference was found between the PLWNT group and CBT group(p༞0.05),but the total effective rate of the PLWNT group was 62.22%, which was higher than the CBT group was 50.00%. The changes in the PLWNT group and CBT group were all higher than those in the HC group except for habitual sleep efficiency and sleep medicine using(p༜0.05). In additional, fatigue degree changes in the PLWBT group were positively correlated with sleep degree (r=0.315) and anxiety degree(r=0.333), but only anxiety degree(r=0.332) was found to be positively correlated with fatigue in the CBT group.
Conclusion

PLWNT Qigong exercise has the potential as a rehabilitation method on CFS with a focus on fatigue, sleep quality, anxiety and depression. Yet, the results need to be interpreted carefully and needs to be repeated in a larger sample. Future studies will expand the sample size for further in-depth research to determine the frequency and intensity of PLWNT Qigong intervention that is particularly beneficial to CFS. The study registered in the American Clinical Trial Registry on 4 November 2018, the registration number is NCT03496961.
Ophiorrhiza Pumila Extract Exhibits Tumor-suppressive Activity in a Mouse Lymphoma Model
Authors: Fan Lixia , Liao Wanqin , Chen Zezhen , Li Shaojing , Yang Anping , Chen Min-Min , Liu Hui , Liu Fang 
Published: October 2021

Abstract
BackgroundRelapse and drug resistance of lymphomas are common, howerver the treatment efficacy of current therapeutic strategies remains unsatisfied. Our current study revealed that the extract of Ophiorrhiza pumila (OPE) has a potential anti-liver cancer activity. In this study, we aimed to investigate the effect of OPE on preventing lymphomas and explored the underlying mechanisms.MethodsCCK-8 assay was applied to detect the effect of OPE on cell proliferation. Flow cytometry was used to analyzed the effect of OPE on cell cycle distribution, and apoptosis. Xenograft mouse model was conducted to determine the anti-tumor activity of OPE. TNUEL assay was performed to detect the apoptosis in tumor tissues. Western blot and immunohistochemistry were used to determined protein expression.ResultsOPE decreased A20 cell proliferation in a dose- and time-dependent manner. OPE treatment induced cell cycle arrest at S phase and elevated apoptosis in A20 cells. Moreover, OPE displayed a significant inhibition in tumor growth in a mouse model. OPE increased apoptosis in tumor tissues revealed by TUNEL assay, which was companied with enhanced cleaved caspase 3 expression and Bax/Bcl2 ratio. In addition, our data showed that OPE suppressed A20 cell viability partially by reducing EGFR phosphorylation.ConclusionsOur data showed that OPE has an inhibitory effect on A20 cell proliferation and tumor growth, which is mediated by inactivation of EGFR and enhanced apoptosis.
The Effect of Self-Care Education With The Telenursing Approach On Health-Promoting Behaviors In Multiple Sclerosis Patients During The COVID-19 Pandemic: A Clinical Trial Study
Authors: Pourfarid Yasaman , Dehghani Ali , Hojat Mohsen 
Published: October 2021

Abstract
Introduction: Chronic conditions of multiple sclerosis (MS) patients are associated with a decrease in health-promoting behaviors and require appropriate nursing interventions. Due to limitations of face-to-face education during the COVID-19 pandemic, telenursing can play an essential role in providing education to patients. Therefore, this study aimed to investigate the effect of self-care education with telenursing approach on health-promoting behaviors in MS patients.Materials and methods: In this clinical trial, 68 patients of the Jahrom MS Society randomly assigned to intervention (n = 34) and control (n = 34) groups. For patients in the intervention group, educational sessions were held three days a week for six weeks. Data were collected using demographic information and Walker's Health-Promoting Lifestyle questionnaires at two stages before and immediately after the intervention. Data were analyzed by Mann-Whitney and Wilcoxon tests using SPSS software (Ver. 21).Results: Based on the findings immediately after the intervention, the mean score of HPBs was significantly higher (p = 0.005) in the intervention group (145.38 ± 26.66) than in the control group (129.18 ± 22.35). Significant differences were observed regarding the mean dimensions of nutrition, exercise, health responsibility, and stress management between the intervention and control groups immediately after the intervention (p < 0.05).Conclusion: Based on the findings, self-care education with the telenursing approach was effective on HPBs in MS patients. Therefore, it is recommended to utilize self-care education with the telenursing approach to control effective behaviors in MS patients during the COVID-19 pandemic.
Chinese Herbs Antagonize The Effects of Bisphenol A On Kiss1 Expression Through Epigenetic Regulation In The Promoter Region
Authors: Dong Wenke , He Jingwei , Wang Junqi , Sun Wen , Sun Yanyan , Yu Jian 
Published: October 2021

Abstract
Background: Bisphenol A (BPA), an environmental endocrine disruptor, is involved in precocious puberty. Chinese Herbs for Nourishing Yin and Purging Fire (NYPF) have been effective in delaying early onset of puberty. However, the underline mechanism is unknown. As epigenetics plays an important role in advanced puberty caused by extraneous factors. We intend to investigate the epigenetic impact of BPA and NYPF herbs on Kiss1 gene, a vital gene driving puberty onset, in hypothalamic neuron cells.Methods: GT1-7 cells derived from GnRH neurons were used in the study. A series of concentration of BPA and serum containing NYPF herbs were prepared in advance. GT1-7 cells were administrated with BPA or vehicle first, followed by NYPF herbs or normal saline (NS) for 24 hours. Afterward, quantification of Kiss1 expression was performed through Realtime-PCR and Weston-blot methods. In addition, epigenetic modifications at Kiss1 promoter were examined through Bisulphite Sequencing (BSP) and Chromatin immunoprecipitation combined real-time PCR（Chip-qPCR）assays.Results: Compared to control group, GT1-7 cells with BPA 10mg/l administration presented lower methylation status (61.25% Vs. 76.56%) concomitantly with enhanced abundance of mixed-lineage leukemia 1(MLL1) (1.05%±0.15 Vs. 0.27%±0.01) and Tri-Methyl-Histone 3 at lysine 4 (H3K4me3) (0.77%±0.51 Vs. 0.02%±0.04) at Kiss1 promoter, leading to elevated expression of Kiss1. On the contrary, TCM for NYPF promoted increased DNA methylation (83.75% Vs. 72.5%), accompanied with less deposition of MLL1/H3K4me3 (MLL1: 0.14%±0.02 Vs. 0.97%±0.09; H3K4me3: 0.01%±0.00 Vs. 0.57%±0.30) at Kiss1 promoter than BPA 10mg/l group, which resulted in markedly inhibition of Kiss1 expression. Conclusions: BPA may induce elevated expression of Kiss1 through influencing DNA methylation and histone modification at Kiss1 promoter. And NYPF herbs reverse the adverse effects of BPA on Kiss1 gene through epigenetic modification as well.
CellPhe: a toolkit for cell phenotyping using time-lapse imaging and pattern recognition
Authors: Wilson Julie C , Wiggins Laura , Lord Alice , O'Toole Peter , Brackenbury William 
Published: October 2021

Abstract
With phenotypic heterogeneity in whole cell populations widely recognised, the demand for quantitative and temporal analysis approaches to characterise single cell morphology and dynamics has increased. We present CellPhe, a pattern recognition toolkit for the characterisation of cellular phenotypes within time-lapse videos. To maximise data quality for downstream analysis, our toolkit includes automated recognition and removal of erroneous cell boundaries induced by inaccurate tracking and segmentation. We provide an extensive list of features extracted from individual cell time series, with custom feature selection to identify variables that provide greatest discrimination for the analysis in question. We demonstrate the use of ensemble classification for accurate prediction of cellular phenotype and clustering algorithms for the characterisation of heterogeneous subsets. We validate and prove adaptability using different cell types and experimental conditions. Our methods could be extended to other imaging modalities, such as fluorescence, and would be suitable for all time-lapse studies including clinical applications.
Neutrons magnetic Mass
Authors: geilhaupt manfred 
Published: October 2021

Abstract
In Quantum Physics the Spin of an elementary particle is defined to be an „intrinsic, inherent“ property. The same to the magnetic moment (μ) due to the spin of charged particles - like Electron (me) and Proton (mp). So the intrinsic spin (S=1/2h-bar) of the electron entails a magnetic moment because of charge (e). However, a magnetic moment of a charged particle can also be generated by a circular motion (due to spin) of an electric charge (e), forming a current. Hence the „orbital motion of charge“ around a „mass-nucleus“ generates a magnetic moment by Ampère’s law. This concept leads to an alternative way calculating the neutrino mass (mν) while discussing the beta decay of a neutron into fragments: proton, electron, neutrino and binding Energy. The change of neutrons magnetic moment during the decay process based on energy and spin and charge conservation allows to calculate the restmass of the neutrino: mν = 0.10(20)eV.
Features of Mirror Visual Feedback Application for Patients With Phantom Limb Pain Under Conditions of Atypical Phantom Position
Authors: But-Husaim Uladzimir , Pirahova Larysa , Yarosh Anastasiya , Vasilevsky Siarhey , Sirytsyna Yuliya , Haltseu Aleh , Haltseu Siarhey , Kapytsky Andrei , Czmiel Vladimir , Stsepiankova Darya 
Published: October 2021

Abstract
One of the most interesting methods of neurorehabilitation is Mirror Visual Feedback (MVF). Despite the widespread information about effectiveness of MVF, specialists who have previously used this method but have not achieved positive results when working with patients, have many questions about the features of the application.The aim of our study was evaluation of the MVF effectiveness for reducing the severity of phantom pain in an amputated limb in conditions of atypical phantom placement. MethodsThe study involved 29 patients with phantom limb pain. The severity of pain and quality of life were assessed. ResultsIt was found that the effectiveness of the MVF depends on some important factors, such as a discrepancy between the location of the phantom at the level of sensations and in reflection, duration and severity of the pain syndrome.ConclusionAn important factor in the successful results of the MVF application is assessment of the initial position of the phantom and ability to change its position in space at the sensory level. A decrease in the severity of phantom pain in patients in the long-term can create the illusion that the patient has adapted to the problem. The timing and frequency of the MVF course should be selected individually, depending on the duration, severity of phantom pain and patient fatigue. It is assumed that the use of MVF in the early period after amputation prevents the development of phantom pain, which requires further research in this direction.
AMSTAR 2 Appraisal of Systematic Reviews and Meta-analyses in the Field of Heart Failure from High-impact Journals
Authors: LI LIN , ASEMOTA IRIAGBONSE ROTIMI , LIU BOLUN , GOMEZ-VALENZIA JAVIER , LIN LIFENG , ARIF ABDUL WAHAB , SIDDIQI TARIQ JAMAL , USMAN MUHAMMAD SHARIQ 
Published: October 2021

Abstract
Background: The MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2 is a critical appraisal tool for systematic reviews (SRs) and meta-analyses (MAs) of interventions. We aimed to perform the first AMSTAR 2-based quality assessment of heart failure-related studies. Methods: Eleven high-impact journals were searched from 2009 to 2019. The included studies were assessed on the basis of 16 domains. Seven domains were deemed critical for high-quality studies. On the basis of the performance in these 16 domains with different weights, overall ratings were generated and the quality was determined to be “high,” “moderate,” “low,” or “critically low.” Results: Eighty-one heart failure-related SRs with MAs were included. Overall, 79 studies were of “critically low quality” and two were of “low quality.” These findings were attributed to insufficiency in the following critical domains: a priori protocols (compliance rate, 5%), complete list of exclusions with justification (5%), risk of bias assessment (69%), meta-analysis methodology (78%), and investigation of publication bias (60%).Conclusions: The low ratings for these potential high-quality heart failure-related SRs and MAs challenge the discrimination capacity of AMSTAR 2. In addition to identifying certain areas of insufficiency, these findings indicate the need to justify or modify AMSTAR 2’s rating rules.
Factors Associated With Viral Suppression and Rebound Among HIV Patients On Treatment: A Retrospective Study in Ghana
Authors: Opoku Stephen , Sakyi Samuel Asamoah , Ayisi-Boateng Nana Kwame , Enimil Anthony Kwame , Senu Ebenezer , Ansah Richard Owusu , Aning Bismark Dankwah , Ojuang Diana Atsieno , Wekesa Doreen Nafula , Ahmed Fatima Osman , Okeke Chidinma B. , Sarfo Ama Darkoaa 
Published: October 2021

Abstract
Background
Viral suppression remains the most desired outcome in the management of patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and this can be achieved by an effective combined Antiretroviral Therapy (cART). However, some patients who achieve viral suppression may experience viral rebound with dire consequence. We evaluated viral suppression and rebound and their associated factors among adult patients on cART in Kumasi, Ghana.
Methods
This hospital-based retrospective study was conducted at the Komfo Anokye Teaching Hospital in Ghana. We reviewed the medical records of 720 HIV patients on cART. Statistical analyses were performed using SPSS Version 26.0 and GraphPad prism version 8.0. P<0.05 was considered statistically significant.
Results
Proportions of patients with viral suppression and viral rebound were 76.1% and 21.0% respectively. Being diagnosed at WHO stage I [aOR=4.26, 95%CI (4.20-48.44), p<0.0001], having good adherence to ART [aOR=5.64, 95%CI (2.86-11.13), p<0.0001], taking Nevirapine-based regimen [aOR=4.66, 95%CI (1.20-18.04), p=0.0260] and increasing duration of treatment (p<0.0001) were independently associated with higher odds of viral suppression. However, being diagnosed at WHO stage II (aOR=7.39, 95%CI: 2.67-20.51; p<0.0001) and stage III (aOR=8.62, 95%CI: 3.16-23.50; p<0.0001), having poor adherence (aOR=175.48, 95%CI: 44.30-695.07; p<0.0001), recording baseline suppression value of 20-49 copies/mL (aOR=6.43, 95%CI: 2.72-15.17; p<0.0001) and being treated with Zidovudine/Lamivudine/Efavirenz (aOR=6.49, 95%CI: 1.85-22.79; p=0.004) and Zidovudine/Lamivudine/Nevirapine (aOR=18.68, 95% CI: 1.58-220.90; p=0.02) were independently associated with higher odds of viral rebound.
Conclusion
Approximately 76% viral suppression rate among HIV patients on cART in Kumasi falls below the WHO 95% target by the year 2030. Choice of ART combination, drug adherence, WHO clinical staging and baseline viral load are factors associated with suppression or rebound. These clinical characteristics of HIV patients must be monitored concurrently with the viral load.
PEMIKIRAN EKONOMI MENURUT SYEKH MUSTHAFA HUSEIN NASUTION
Authors: Siregar Siti Hairani , Hasan Asyari 
Published: October 2021

ABSTRAK: Penelitiaan yang berjudul Pemikiran Ekonomi Menurut Syekh Musthafa Husein Nasution ini bertujuan untuk mengetahui bagaimana pemikiran ekonomi menurut Syekh Musthafa Husein, seorang ulama Indonesia dan pendiri Pondok Pesantren Musthafiwayah Purba Baru. Keberadaan pesantren Mustahafawiyah di tengah masyarakat desa Purba Baru telah memebrikan dampak yang sangat baik bagi perekonomian masyarakat sekitar dan desa ini menjadi dikenal oleh masyarakat luas. Sebagai ulama dan tokoh di Mandailing Natal (Sumatera Utara), konsep-konsep dan pemikiran yang beliau bangun ternyata tidak hanya sebatas keagamaan saja, tetapi telah meluas pada aspek kehidupan masyarakat dan bangsa, seperti dalam pertanian, politik, dan ekonomi.
TA’AWUNI-BASED MICRO INSURANCE MODEL BAGI UMKM: UPAYA MENDUKUNG PENGEMBANGAN EKOSISTEM INDUSTRI HALAL PASCA COVID-19 DI INDONESIA
Authors: Sulaeman Sulaeman , Wirawan Amaliyah 
Published: October 2021

Abstrak: Penelitian ini bertujuan untuk mengusulkan model asuransi mikro syariah yakni Ta’awuni-Based Micro Insurance Model yang berdasarkan prinsip saling tolong menolong (ta’awun) sebagai upaya dalam mengurangi beban/risiko khususnya untuk UMKM yang terlibat dalam industri produk/jasa halal pasca pandemic COVID-19 di Indonesia. Dengan menggunakan analisis BOCR, model asuransi mikro syariah berbasis prinsip ta’awun ini dapat memberikan keuntungan bagi UMKM yang berada di sektor industri halal dan bagi perusahaan asuransi syariah/LKMS dalam mendukung program-program pemerintah seperti program pemulihan ekonomi nasional (PEN) khususnya bagi UMKM yang bergerak di industri halal terlebih setelah pandemik COVID-19 di Indonesia. Selain itu, ada risiko yang akan dihadapi baik oleh perusahaan asuransi syariah maupun LKMS dalam mengimplementasikan model ini bagi UMKM seperti moral hazard. Namun, tata kelola yang baik dan pengaplikasian IT dapat mengurangi dan mencegah adanya berbagai risiko termasuk risiko moral hazard yang berpeluang timbul pada penerapan model ini. .
Kata kunci: Asuransi Mikro Syariah, UMKM, COVID-19, Indonesia

Abstract: This study aims to propose a sharia micro insurance model, namely the Ta'awuni-Based Micro Insurance Model which is based on the principle of mutual help (ta'awun) as an effort to reduce the burden/risk, especially for MSMEs involved in the halal industry after the COVID-19 pandemic in Indonesia. By using BOCR analysis, this sharia microinsurance model based on ta'awun principles can provide benefits for MSMEs in the halal industry sector and for sharia insurance companies/Islamic Microfinance Institutions (IMFIs) in supporting government programs such as Economic Recovery Program (Pemulihan Ekonomi Nasional), especially for MSMEs in the halal industry after the COVID-19 pandemic in Indonesia. In addition, there are risks that will be faced by both sharia insurance companies and IMFIs in implementing this model for MSMEs such as moral hazard. However, good governance and the application of IT can reduce and prevent various risks, including the risk of moral hazard that may arise in the application of this model.
Keywords: Islamic Micro Insurance, MSMEs, COVID-19, Indonesia
ANALISIS PRAKTIK MINDRING MODERN
Authors: Lailyah Nurzahroh , Yasin Rozaq Muhammad , Saputri Pungky Lela 
Published: October 2021

This research aims to analyze the practice of Mindring Modern Jaya Mandiri in Kudus from the view of the National Sharia Council (DSN) fatwa of the Indonesian Ulema Council (MUI) No. 110/DSN-MUI/IX/2017 about sale and purchase contracts. This research is a qualitative research with a case study approach. The method used in this research is interview, observation, and documentation. The data validity technique used is triangulation, with analytical procedures including data reduction, data display, making conclusions and verification. The results of this study indicate that the practice of Mindring Modern Jaya Mandiri Kudus is not in accordance with the fatwa of DSN MUI No: 110/DSN-MUI/IX/2017. The use of the lease-purchase contract is not in accordance with the practice of mindring. The appropriate contract is bai’ al-taqsith.
Cortical bone microdamage produced by micro-osteoperforation screws versus orthodontic miniscrews: an in vitro study
Authors: Chan Celine , Dreyer Craig , Sampson Wayne 
Published: October 2021

Abstract

Background/objective
The alternative use of Orthodontic Miniscrew Implants (OMIs), traditionally used for skeletal anchorage, to facilitate micro-osteoperforations (MOPs) for accelerating orthodontic tooth movement has been reported in previous studies. The objective of the present in vitro study was to compare the microdamage generated by OMIs and MOP-purposed screws of similar dimensions in porcine cortical bone.

Materials and methods
Forty rectangular porcine cortical bone specimens of 1.5 mm thickness were produced and divided into two equal groups. According to group allocation, either a single MOP screw or OMI was inserted and later removed. A sequential staining protocol was carried out to distinguish true microdamage created upon screw insertion and removal from iatrogenic damage. The bone specimens were imaged by a confocal laser scanning microscope, and five histomorphometric measurements described and quantified the generated microdamage.

Results
On the entry (outer) bone surface, the OMI screws produced greater microdamage which reached statistical significance across all of the histomorphometric parameters. In contrast, a statistically significant increase in microdamage was created following MOP screw insertion on the exit (inner) bone surface, but only in three assessment parameters, recorded as total damage area, as well as diffuse damage area and radius.

Conclusions
Overall, the present study showed that 1.5 mm OMIs produced slightly greater microcrack-type and diffuse damage-type microdamage than the 1.6 mm diameter MOP screws. However, these differences were small and considered clinically insignificant.