bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUNAN KALIJAGA’S DA'WAH STRATEGY IN SULUK LINGLUNG AND ITS IMPLICATION TO INDONESIAN RADICALISM MOVEMENT
Authors: Muslih Mohammad , Rohman Abdul , Ahmad Ahmad , Saifullah Ahmad 
Published: June 2021

Sunan Kalijaga was known as a creative da’i in spreading da'wah. One of the media for his da’wah is a literary work entitled Suluk Linglung. In the Suluk Linglung manuscript, two da’wah strategies had been employed by Sunan Kalijaga, both of which were expected to be relevant if applied in Indonesia today, considering the many issues of radicalism. This research is a literature review. Data were collected by using documentation method through a research on Suluk Linglung. Therefore, to dissect the contents of the manuscript, the author uses qualitative research methods and Gadamer's hermeneutic approach. Finally, it suggested that Sunan Kalijaga used two da'wah strategies, Sufistic da'wah strategy and multicultural da’wah strategy. It is expected that the use of the strategies in the current da’wah can dismiss the radicalism movement. Therefore, it brings out the principle of da’wah that is gentle, friendly, and nurturing to people, or da'wah rahmatan li-l 'alamin.Sunan Kalijaga dikenal sebagai seorang da’i yang kreatif dalam menyebarkan dakwah. Salah satu media dakwah beliau adalah melalui karya sastra yang berjudul Suluk Linglung. Dalam manuskrip Suluk Linglung tercermin dua strategi dakwah yang pernah dilakukan oleh Sunan Kalijaga, yang keduanya itu diharapkan akan relevan jika diterapkan di Indonesia pada zaman sekarang meninjau banyak sekali isu radikalisme. Penelitian ini berjenis kajian kepustakaan. Metode pengumpulan data menggunakan metode dokumentasi melalui penelitian manuskrip Suluk Linglung. Oleh karenanya, agar dapat membedah isi manuskrip Suluk Linglung, penulis menggunakan metode penelitian kualitatif dan menggunakan pendekatan hermeneutika Gadamer. Adapun untuk teknik analisa data menggunakan teknik analisis isi. Akhirnya, setelah melakukan penelitian lebih lanjut peneliti mendapatkan hasil bahwasanya dalam manuskrip Suluk Linglung, Sunan Kalijaga menggunakan dua strategi dakwah yang meliputi strategi dakwah sufistik dan strategi dakwah multikultural. Jika dua strategi dakwah tersebut diterapkan pada zaman sekarang, maka diharapkan akan berimplikasi terhadap gerakan radikalisme yakni menepis gerakan radikalisme. Sehingga, akan memunculkan prinsip dakwah yang lembut, ramah, dan mengayomi kepada mad’u atau dapat disebut sebagai dakwah rahmatan li-l ‘alamin.
Longstanding Nonunion of Metatarsal Fractures in an Adult Patient with Autosomal Dominant Osteopetrosis
Authors: Sidhu Arashdeep , Birk Manjot , Nacht Jeffrey L. 
Published: June 2021

Case:
Osteopetrosis is a genetic condition that impairs bone turnover as the result of defects in osteoclast function and abnormal ossification of bone. Autosomal dominant osteopetrosis is often mild; however, the impaired fracture healing, increased density, and hardness of osteopetrotic bone present technical challenges for surgeons leading to complications with both nonoperative and operative treatment modalities. In this case report, we describe a patient treated empirically with ultrasonic bone stimulation for nonunion of fractures of multiple metatarsals after a failure of conventional therapy.

Conclusion:
Ultrasonic bone stimulation may have a role in optimizing nonoperative management of osteopetrosis-related fractures in adults.
Transtibial Osseointegration for Patients with Peripheral Vascular Disease
Authors: Akhtar Muhammad Adeel , Hoellwarth Jason Shih , Al-Jawazneh Shakib , Lu William , Roberts Claudia , Al Muderis Munjed 
Published: June 2021

Background:
The management of peripheral vascular disease (PVD) can require amputation. Osseointegration surgery is an emerging rehabilitation strategy for amputees. In this study, we report on 6 patients who had PVD requiring transtibial amputation (PVD-TTA) and either simultaneous or subsequent osseointegration (PVD-TTOI).

Methods:
Six patients (aged 36 to 84 years) with transtibial amputation and preexisting PVD underwent osseointegration between 2014 and 2016 and were followed for 3 to 5 years. Pre- and postoperative clinical and functional outcomes (pain, prosthesis wear time, mobility, walking ability, and quality of life) and adverse events (infection, fracture, implant failure, revision surgery, additional amputation, and death) were prospectively recorded.

Results:
All patients’ mobility improved following osseointegration. Three patients initially had required the use of a wheelchair, precluding baseline walking tests; the other 3 were classified as K level 1 or 2, with mean baseline Timed Up and Go (TUG) test = 14.0 ± 2.2 s and 6-Minute Walk Test (6MWT) = 262 ± 75 m. At the time of the latest follow-up, all patients were K level 2 or 3; mean TUG = 12.7 ± 7.2 s and 6MWT = 353 ± 148 m. Four patients wore their prosthesis ≥16 hours daily. Three patients had superficial soft-tissue infections. One other patient experienced recurrent infections 2.8 years after osseointegration requiring debridements and transfemoral amputation; the patient died 2 days following surgery from myocardial infarction caused by coronary atherosclerosis.

Conclusions:
All 6 patients who underwent PVD-TTOI in this case series survived through 2 years. Patients who initially had used a wheelchair achieved and maintained independent, unaided ambulation until PVD-related impairments in the contralateral leg occurred in 1 patient. Patients previously using a traditional socket prosthesis reported improvement in mobility and quality of life. One patient’s death underscores the importance of careful patient selection. However, marked improvement in the other 5 patients suggests cautious optimism that PVD-TTA is not an absolute osseointegration contraindication. Conscientious further investigation seems appropriate.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Complications, Reoperations, and Mid-Term Outcomes Following Anterior Vertebral Body Tethering Versus Posterior Spinal Fusion
Authors: Shin Max , Arguelles Gabriel R. , Cahill Patrick J. , Flynn John M. , Baldwin Keith D. , Anari Jason B. 
Published: June 2021

Background:
Anterior vertebral body tethering (AVBT) is a growth-modulation technique theorized to correct adolescent idiopathic scoliosis (AIS) without the postoperative stiffness imposed by posterior spinal fusion. However, data are limited to small series examining short-term outcomes. To assess AVBT’s potential as a viable alternative to posterior spinal fusion (PSF), a comprehensive comparison is warranted. The purpose of this meta-analysis was to compare postoperative outcomes between patients with AIS undergoing PSF and AVBT. Our primary objective was to compare complication and reoperation rates at available follow-up times. Secondary objectives included comparing mid-term Scoliosis Research Society (SRS)-22 scores, and coronal and sagittal-plane Cobb angle corrections.

Methods:
We performed a systematic review of outcome studies following AVBT and/or PSF procedures. The inclusion criteria included the following: AVBT and/or PSF procedures; Lenke 1 or 2 curves; an age of 10 to 18 years for >90% of the patient population; <10% non-AIS scoliosis etiology; and follow-up of ≥1 year. A single-arm, random-effects meta-analysis was performed. Deformity corrections, complication and reoperation rates, and postoperative SRS-22 scores were recorded.

Results:
Ten AVBT studies (211 patients) and 14 PSF studies (1,069 patients) were included. The mean follow-up durations were similar for both groups. Pooled complication rates were 26% for AVBT versus 2% for PSF, and reoperation rates were 14.1% for AVBT versus 0.6% for PSF with nonoverlapping confidence intervals (CIs). The pooled reoperation rate among studies with follow-up times of ≥36 months was 24.7% in AVBT versus 1.8% in PSF. Deformity correction, clinical outcomes, and mid-term SRS-22 scores were similar.

Conclusions:
Our study showed greater rates of complications and reoperations with AVBT compared with PSF. Reoperation rates were significantly greater in AVBT studies with longer follow-up (≥36 months). Deformity correction, clinical outcomes, and mid-term SRS-22 scores were similar. While a potential fusionless treatment for AIS merits excitement, clinicians should consider AVBT with caution. Future long-term randomized prospective studies are needed.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Hypothyroidism and Leptin in Iraqi Patients with Chronic Kidney Disease
Authors: Luaibi Noori Mohammed , Falhi Athraa K. , Alsaedi Ali J. 
Published: June 2021

The present study aims at assessing the effects of chronic kidney disease (CKD) on thyroid hormone and leptin by evaluating the level of: leptin hormone along with thyroid hormone in CKD patients. The study has been conducted on 70 subjects, 50 patients with an age range between 20-50 years (25 males and 25 females) who were diagnosed to have CKD stage-5, and 20 normal controls whose ages ranged between 20-48 years (10 males and 10 females), who attended the Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April 2018 to July 2018. The study showed a highly significant (P<0.01) increase in TSH level in CKD patients in comparison with controls. While T3 and T4 levels observed highly significant decrease (P<0.01) in CKD patients in comparison with their control groups; on the other hand, in Leptin levels, it has been demonstrated a highly significant (P<0.01) increase in CKD patients compared to the controls. Also there was a significant (P<0.05) positive correlation between TSH and Leptin, while the results showed a highly significant (P<0.01) negative correlation between T3, T4 and Leptin. To conclude, this study confirms that thyroid dysfunction and hyperleptinemia have been found to be very common in CKD patients and reveals the significant association between CKD progression and thyroid dysfunction and hyperleptinemia.
Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale
Authors: Singer Susanne , Hammerlid Eva , Tomaszewska Iwona M. , Amdal Cecilie Delphin , Bjordal Kristin , Herlofson Bente Brokstad , Santos Marcos , Silva Joaquim Castro , Mehanna Hisham , Fullerton Amy , Brannan Christine , Gonzalez Loreto Fernandez , Inhestern Johanna , Pinto Monica , Arraras Juan Ignacio , Yarom Noam , Bonomo Pierluigi , Baumann Ingo , Galalae Razvan , Nicolatou-Galitis Ourania , Kiyota Naomi , Raber-Durlacher Judith , Salem Dina , Fabian Alexander , Boehm Andreas , Krejovic-Trivic Sanja , Chi Wei-Chu , Taylor Katherine , Simon Christian , Licitra Lisa , Sherman Allen C 
Published: June 2021

Abstract
Purpose The aim of this study was to explore what methods should be used to determine the minimal important difference (MID) and minimal important change (MIC) in scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43.Methods In an international multi-centre study, patients with head and neck cancer completed the EORTC QLQ-HN43 before the onset of treatment (t1), three months after baseline (t2), and six months after baseline (t3). The methods explored for determining the MID were: 1) group comparisons based on performance status; 2) 0.5 and 0.3 standard deviation and standard error of the mean. The methods examined for the MIC were patients' subjective change ratings and receiver-operating characteristics (ROC) curves, predictive modelling, standard deviation, and standard error of the mean. The EORTC QLQ-HN43 Swallowing scale was used to investigate these methods.Results From 28 hospitals in 18 countries, 503 patients participated. Correlations with the performance status were |r|<0.4 in 17 out of 19 scales; hence, performance status was regarded as an unsuitable anchor. The ROC approach yielded an implausible MIC and was also discarded. The remaining approaches worked well and delivered MID values ranging from 10 to 14; the MIC for deterioration ranged from 8 to 16 and the MIC for improvement from -3 to -14.Conclusions For determining MIDs of the remaining scales of the EORTC QLQ-HN43, we will omit comparisons of groups based on the Karnofsky Performance Score. Other external anchors are needed instead. Distribution-based methods worked well and will be applied as a starting strategy for analyses. For the calculation of MICs, subjective change ratings, predictive modelling, and standard-deviation based approaches are suitable methods whereas ROC analyses seem to be inappropriate.
One-year results and safety of femtosecond arcuate incisions for high post-keratoplasty astigmatism treatment: time to rethink the procedure?
Authors: Kwitko Sergio , de Araujo Bruno Schneider , Cabral Felipe Pigozzi , Neubauer Nessana 
Published: June 2021

Abstract
Background/Aims High astigmatism after keratoplasty is the main limiting factor for visual rehabilitation. Among its treatment options the arcuate keratotomy (AK) with the femtosecond laser stands out for its perfection and versatility of the incision making. We designed a study to evaluate the results and safety of femtosecond arcuate keratotomy (femto-AK) in the treatment of high astigmatism after keratoplasty.Methods A prospective interventional cohort study. We enrolled 17 eyes with high degree of irregular astigmatism, scheduled for Femto-AK. IntraLase FS was used to perform arcuate incisions 1.00 mm inside the graft. Patients’ uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BDCVA), and astigmatic change were recorded and followed up to one year after surgery.Results Despite overall improvement in corneal cylinder and visual acuity in one-year follow-up, there was a 52.9% complication rate. Cylinder overcorrection occurred in 6 cases (35.3%) that was managed with compressive sutures; microperforation occurred in two cases (11.7%); and endothelial rejection in one case (5.9%).Conclusion The predictability of astigmatism correction was variable in reducing postkeratoplasty astigmatism and high complication rate was found in our case series. New nomograms and improvements in technique need to be developed in order to reduce the incidence of overcorrections.
Giant Intramuscular Lipoma of Biceps Brachii – A Rare Case Report
Authors: Nizam Saifullah , Kardam Dinesh , Yelamanchi Raghav , Khurana Udit 
Published: June 2021

Abstract
Lipomas are benign mesenchymal tumors. They are the most common type of soft tissue tumors. Intramuscular lipoma is a relatively uncommon condition and accounts for about1.8% of all primary tumors of adipose tissue and are relatively rare in upper extremity. When deep, large and unusual in location, magnetic resonance imaging (MRI) can identify and localise these tumours and is the best modality to differentiate lipoma and liposarcoma. We report an extremely rare and interesting case of giant intramuscular biceps brachii lipoma. A 22-year male patient presented with insidious onset, firm and non-tender swelling in the left elbow without any distal neurovascular deficits. MRI and biopsy were suggestive of lipoma. Wide local excision was done and patient had an uneventful recovery. Post-operative histopathology was suggestive of lipoma. To conclude, intramuscular giant lipoma of biceps brachii is an infrequent clinical entity due to its location. Imaging is necessary to differentiate it from its malignant counterpart and to plan surgical management.
Experimental and theoretical study of a new CDI device for the treatment of desulfurization wastewater
Authors: Liu Chang , Ma Lan , Xu Yongyi , Wang Feng , Tan Yu , Huang Luyue , Ma shuangchen 
Published: June 2021

Abstract
According to the characteristics of desulfurization wastewater, A new capacitive deionization (CDI) device was designed to study the desalination characteristics of desulfurization wastewater in this paper. The experiments investigated the desalination efficiency under different conditions which find that the best desalination efficiency is achieved at a voltage of 1.2V, pH = 11 and 50℃. Besides, the ion adsorption is more favorable under acidic and alkaline conditions. The anion and cation removal performance experiments showed that the order of cation removal is Mg2+༞Na+༞Ca2+༞K+ and the order of anion removal is Cl−༞CO32−༞NO3−༞SO42−༞HCO3−. The mechanism of CDI was studied and analyzed by isothermal adsorption model and COMSOL simulation software. It was found that the Freundlich model and Redlich-Peterson model have a good fit with the experimental results. The experiments show that the CDI device has excellent stability. CDI device was used to treat actual desulfurization wastewater. Furthermore, the study provides theoretical support for the industrial application of CDI for desulfurization wastewater treatment in the future.
Novel Azabicyclononane (ABN-5d) Derivative Inhibits Carrageenan-Induced Rat Hind Paw Edema
Authors: R Bhavapriya , Manickam Venkatraman , Ramasamy Tamizhselvi , Radhakrishnan Vidya , Iyer Sathiyanarayanan Kulathu 
Published: June 2021

Abstract
Purpose: Recent reports confirm the anti-inflammatory role of 3-azabicyclononane ring-based phytochemicals derived from a variety of plant alkaloids. We recently synthesized and established preliminary cytotoxic activities on different cancer cell lines. Further to characterize the azabicyclononane compounds, in this study we unravelled the mechanism involved in the anti-inflammatory effect of a novel azabicyclononane derivative (ABN-5d). Methods: Carrageenan-induced (1% intraplantar injection) rat hind paw edema model was used for the induction of inflammation. The synthesized azabicycle derivative ABN-5d (0.5, and 1.0 mg/kg) was administered intraperitoneally to rats 1hr before the injection of carrageenan. Paw volume as the index of inflammation was measured before and after the administration of carrageenan.Results: Carrageenan-induced peripheral inflammation in the rat. ABN-5d administration significantly decreased carrageenan-induced paw histopathological changes, myeloperoxidase (MPO) activity, H2S, NO level, TNF-α, CSE, and iNOS gene expression in a dose-dependent manner (p < 0.001). We also demonstrated that ABN-5d significantly reduced carrageenan-induced NF-κB activation and IκBα degradation in the inflamed paw tissue. Conclusion: These results indicate that the anti-inflammatory effect of ABN-5d on carrageenan-induced rat paw edema could be via the inhibition of the iNOS/NO-CSE/ H2S -NFκB pathway.
Ultra-Early Indicators of Acute Hypertriglyceridemic Pancreatitis May Influence Treatment Decision-Making By Chinese Doctors
Authors: Wu Jing , Liang Yizhi , Tang Xiaoting , Rao Zilan , Li Chaowei , Pan Xiaoping , Fang Taiyong 
Published: June 2021

Abstract
Background: This study investigates whether ultra-early indicators can predict severity of acute hypertriyceridemic pancreatitis (HTGP) and affect clinical decisions. Methods: For this observational retrospective study, we analyzed data of 110 HTGP patients enrolled between January 2017 and February 2020. HTGP patients were categorized into mild acute pancreatitis (MAP) and moderately severe acute pancreatitis-severe acute pancreatitis (MSAP-SAP) groups, based on their final clinical outcomes. Demographic and clinical data were collected and ultra-early indicators (serum calcium, triglyceride (TG), interleukin-6(IL-6), D-dimer, hemoglobin A1c(HbAc1), arterial lactate) levels were measured within 6 hours of admission. A multivariate logistic regression analysis model and receiver operating characteristic curve were used to determine ultra-early indicators values of high-risk patients. The chi-square test method was applied to estimate the hospitalization time and associated complications in MSAP-SAP group post-plasma exchange within or more than 24 hours. Results: Among the 110 HTGP patients, 56 were in the MAP group whereas, 54 were in the MSAP-SAP group. TG, IL-6, D-dimer, HbAc1, and arterial lactate levels measured within 6 hours after admission were significantly higher in the MSAP-SAP group, but serum calcium was significantly lower, versus the mild AP group. IL-6, D-dimer and serum calcium were identified as the risk factors for MSAP-SAP and were potential ultra-early indicators for predicting HTGP severity within 6 hours of admission. MSAP-SAP patients that underwent blood purification therapy within 24 hours of admission had a shorter hospitalization time than those treated 24 hours post-admission. Conclusion: The present study reveals IL-6, D-dimer, and serum calcium - ultra-early indicators - as promising biomarkers in the assessment of AP severity in HTGP patients within 6 hours. Early blood purification presents a novel therapy among MSAP-SAP patients within 24 hours and is associated with fewer complications and a shorter hospitalization time. However, traditional therapy can be further integrated to manage MAP patients effectively with less medical expenses.
Impact of COVID-19 on Mental Health of Palliative Care Professionals and Services: A Mixed Method Survey Study
Authors: Chan Wallace Chi Ho , Woo Raymond Kam Wing , Kwok Denis Ka-Shaw , Yu Clare Tsz Kiu , Chiu Lawrence Man-Hon 
Published: June 2021

Abstract
Background: The impact of the COVID-19 pandemic on the mental health of health care professionals is profound, but few studies have examined this phenomenon. The way palliative care services have been affected during the pandemic remains underexplored. This study aimed to 1. examine the mental health of palliative care professionals during the pandemic and the relationship of mental health with socio-demographic factors; and 2. explore the impact of the pandemic on palliative care services. Methods: A cross-sectional survey study was conducted, and 142 palliative care professionals from public hospitals in Hong Kong completed an online questionnaire, which includes measurements on depression, anxiety, perceived stress, post-traumatic stress, professional quality of life, and 15 questions on the effect of COVID-19 on palliative care services. Descriptive and multivariate regression analyses were conducted. Quantitative and qualitative data about the impact of COVID-19 on palliative care services were analyzed and triangulated using a mixed-methods approach. Results: Our findings indicated that 82%, 43% and 42% of the participants felt moderately to highly stressed, anxious, and depressed during the pandemic. Female professionals who are younger or have no religious belief tended to have poorer mental health. Qualitative findings identified three themes which affected the provision of palliative care: 1. the tightening of restrictions on visitors; 2. The limited provision of services; and 3. staff deployment. Conclusions: This study suggests the need for concern about the mental health of palliative care professionals and for developing strategies of coping with the challenges during the pandemic.Trial registration: N/A (This paper does not involve a health care intervention)