bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profitability improvement of a reservoir power station based on virtual reservoir bidding
Authors: Zhu Yanmei , Huang Weibin , Chen Shijun , Ma Guangwen , Liu Yue 
Published: March 2021

Abstract
Compared with a run-of-river power station, a reservoir power station (RPS), with the capacity of a seasonal regulation function and more, has the unique and irreplaceable attributes of its role in the power grid and society at large. However, under the current power system and market environment in China, these attributes cannot be effectively utilised, resulting in heavy losses to enterprises. It is inevitable for RPSs to participate in the market; therefore, how to improve the profitability of RPS enterprises has become an urgent problem requiring a solution. Based on the control effect on run-off of RPS in a river basin, a new cascade hydropower bidding method and the associated bidding process are proposed. The market entities of the new bidding method are composed of cascade hydropower joints with the RPS as the boundary. The bidding unit benefit-sharing mechanism is constructed, and the accounting method for the benefit-sharing price of the RPS is established, which finally achieves the goal of improving the profitability of the RPS enterprise.
Anti-breast Cancer Potential of Natural and Synthetic Coumarin Derivatives
Authors: Song Feng , Huo Xiankai , Guo Zeying 
Published: March 2021

:
Breast cancer is the most frequent female cancer and one of the leading causes of cancer
death in women. There are many chemotherapy agents available for the treatment of breast cancer.
Still, the current therapeutic options have not fulfilled the desired outcomes, especially for drug-resistant
breast cancer therapy. Thus, there is an urgent need to develop novel anti-breast cancer
agents. Coumarin is ubiquitous in natural and synthetic bioactive compounds, and coumarin derivatives
readily interact with a variety of enzymes and receptors in breast cancer cells. Moreover, the
coumarin-based irosustat as the first-generation steroid sulfatase inhibitor in breast cancer is under
clinical evaluation, revealing the potential of coumarin derivatives as novel anti-breast cancer
agents. This review aims to describe the recent development of natural and synthetic coumarin derivatives
with anti-breast cancer potential, covering the articles published from 2015 to 2020.
Selective Cytotoxic Effects of 5-Trifluoromethoxy-1H-indole-2,3-dione 3-Thiosemicarbazone
Derivatives on Lymphoid-originated Cells
Authors: Danışman-Kalındemirtaş Ferdane , Erdem-Kuruca Serap , Akgün-Dar Kadriye , Karakaş Zeynep , Soylu Özge , Karali Nilgün 
Published: March 2021

Aim:
The present study aims to identify the anticancer effect of novel 1H-indole-2,3-dione 3-
thiosemicarbazone derivatives. These compounds could be promising anticancer agents in leukemia treatment.

Background :
Conventional chemotherapeutic agents accumulate in both normal and tumor cells due to nonspecificity.
For effective cancer treatment, new drugs need to be developed to make chemotherapeutics selective
for cancer cells. The ultimate goal of cancer treatment is to reduce systemic toxicity and improve the quality of
life.

Method:
In this study, the anticancer effects of 5-trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone
derivatives (A-L) were investigated in chronic myelogenous leukemia K562, Burkitt’s lymphoma P3HR1, acute
promyelocytic leukemia HL60 cells, and vincristine-resistant sublines of K562 and P3HR1 cells. Additionally,
the compounds were tested on lymphoid-derived cells from ALL patients. In order to investigate the particular
mechanism of death caused by the cytotoxic effects of the compounds, immunohistochemical caspase 3 staining
was performed in P3HR1 cells, and the resulting apoptotic activities were demonstrated.

Result:
All tested compounds have been found to have cytotoxic effects against lymphoma cells at
submicromolar concentrations (IC50= 0.89-1.80 μM). Most compounds show significant selectivity for the
P3HR1 and P3HR1 Vin resistance. The most effective and selective compound is 4-bromophenyl substituted
compound I (IC50=0.96 and 0.89 μM). Cyclohexyl and benzyl substituted compounds D and E have also been
found to have cytotoxic effects against K562 cell lines (IC50=2.38 μM), while the allyl substituted compound C is
effective on all cell lines (IC50=1.13-2.21 μM). 4-Fluorophenyl substituted F compound has been observed to be
effective on all cells (IC50=1.00-2.41 μM) except K562 cell. Compound C is the only compound that shows
inhibition of HL-60 cells (IC50= 1.13 μM). Additionally, all compounds exhibited cytotoxic effects on lymphoidderived
cells at 1μM concentration. These results are in accordance with the results obtained in lymphoma cells.

Conclusion:
All compounds tested have submicromolar concentrations of cytotoxic effects on cells. These
compounds hold potential for use in future treatments of leukemia.
Media Fill Test for Validation of Non-Radioactive Kit for Radiopharmaceutical
Preparations
Authors: Mariani Marco , Vincenti Sara , Scotognella Teresa , Bruno Stefania , Boninti Federica , Cambieri Andrea , Damiani Gianfranco , Laurenti Patrizia , Giordano Alessandro 
Published: March 2021

Introduction:
The administration of improperly prepared intravenous fluids might determine
healthcare-associated infections. Quality and sterility assurance in radiopharmaceutical manufacturing
products must be evaluated by media fill tests that simulate the performance of the aseptic
manufacturing procedure. The aim of this study is to show a methodological modification of a
specific step of media fill tests, giving an overview of economic and organizational advantages that
it might bring.

Materials And Methods:
Media fill tests were conducted to ensure that they reproduce as strictly
as possible the routine aseptic production process with all the critical steps described in the internal
Standard Operating Procedures. We introduced an innovative modification in step 1: instead of using
a completely decayed 99Mo/99mTc generator, we used a99Mo/99mTc generator just before its disposal,
eluting it with saline solution aspirated in an empty vacuum vial.

Results:
A total of 47 production runs were performed, and a total of 799 vials were tested for
sterility. Thirteen nuclear medicine technicians were assessed. We found contamination in 1% of
the total number of vials analyzed.

Conclusions:
The modification proposed shows several advantages: reduction of the costs of the
media fill tests, the possibility to manage these without referring to external services, and decreased
injuries for technicians who perform the tests.
Telehealth Transition Assistance Program for Acute Spinal Cord Injury Caregivers: Protocol for a Mixed-Methods, Randomized Controlled Trial
Authors: Perrin Paul B , McDonald Scott D , Watson Jack D , Pierce Bradford S , Elliott Timothy R 
Published: March 2021

Background
While spinal cord injury (SCI) caregiving can be a rewarding experience, caregivers often experience reduced mental and physical health.

Objective
This article describes the methodology of a study examining the efficacy of a newly developed telehealth Transition Assistance Program (TAP) for caregivers of individuals with acute SCI.

Methods
A mixed-methods, randomized controlled trial is comparing TAP outcomes to that of a standard-of-care control. The study is recruiting for 48 months and incorporating quantitative outcome measures.

Results
This study was funded by the Craig H. Neilsen Foundation in April 2017. It was approved by the institutional review boards at Virginia Commonwealth University and the Hunter Holmes McGuire Veterans Affairs Medical Center that same year. Participant recruitment and data collection began in 2018.

Conclusions
This study is implementing and testing an SCI caregiver intervention unlike any created before, targeting a critical time period that, until now, other SCI caregiver interventions have overlooked. Research personnel intend to disseminate the intervention and study findings through the publication of manuscripts and presentations at conferences. If the current study shows improvements in caregiver or patient well-being, the TAP for SCI caregivers could become part of the standard of care for acute SCI.

Trial Registration
ClinicalTrials.gov NCT03244098; https://www.clinicaltrials.gov/ct2/show/NCT03244098

International Registered Report Identifier (IRRID)
DERR1-10.2196/28256
Implementasi Metode Advance Encryption Standard dan Least Significan Bit pada Kriptografi Citra Digital
Authors: Aisa Sitti , Aini Nurul 
Published: March 2021

<p><em>Perkembangan digital kian pesat tanpa kita sadari, salah satunya adalah kehadiran smartphone sudah menjadi salah satu kebutuhan pokok untuk masyarakat. Dimana, smarphone tidak hanya digunakan sebagai alat komunikasi tetapi juga sebagai alat bertukar informasi. </em><em>Sistem pertukaran data dan informasi melalui Smartphone Android tidak memberi jaminan akan keamanan informasi khususnya untuk data yang bersifat rahasia. Pertukaran data dan informasi dengan cara seperti ini rentang terhadap bahaya pencurian data, sehingga perlu mencari solusi untuk hal tersebut. Diperlukan suatu sistem pengamanan data dan informasi terutama untuk data yang bersifat pribadi dan rahasia sehingga dapat sampai ke tangan yang berhak menerima. Salah satu metode yang sering digunakan untuk mengatasi hal tersebut dengan teknik kriptografi.salah satu metode yang digunakan adalah AES dan LSB Dengan metode AES ini, data diubah kedalam bentuk teks yang tidak diketahui maknanya agar orang lain tidak bisa membacanya dan untuk menghindari kecurigaan kepada orang lain maka si A menggunakan teknik steganografi dengan metode LSB. Aplikasi ini untuk mengamankan data yang akan dikirmkan pengamanan dilakukan dengan dua tahapan yang pertama tahap penyamaran pesan dengna metode AES dan tahap kedua adalah tahap penyisipan pesan dengan metode LSB, dimana cipherteks yang disimpan dalam bentuk file text, serta dapat disisipkan ke dalam file citra.</em></p>
LEVANTAMENTO DA FERTILIDADE DO SOLO DE PROPRIEDADES RURAIS DO MUNÍCIPIO DE CHAPECÓ - SC: UM ESTUDO DE CASO
Authors: Polesso Alana Maria , Spagnollo Evandro , Baretta Carolina Riviera Duarte Maluche 
Published: March 2021

O manejo da fertilidade do solo é a base para a busca do aumento da produtividade e inclui a análise de solo como medida para correção da acidez e, posteriormente, aplicações de fertilizantes. O estudo objetivou caracterizar a fertilidade média de áreas rurais do município de Chapecó - SC, a partir do banco de dados de análises realizadas nos anos de 2016 e 2017 fornecido pelo Laboratório de Solos da Epagri - Chapecó. Foram avaliados 147 laudos e interpretados os seguintes atributos químicos do solo: pH - água, saturação por alumínio (m%), capacidade de troca de cátions a pH 7,0 (CTCpH7,0), fósforo (P), potássio (K), matéria orgânica do solo (MOS), cálcio (Ca), magnésio (Mg) e saturação por bases (V%). Os teores dos nutrientes foram interpretados segundo suas classes de disponibilidade conforme o Manual de Calagem e Adubação para os estados do Rio Grande do Sul e Santa Catarina, e analisados por estatística descritiva. A maior frequência de pH ocorreu para valores menores que 5,5 (53%) e entre 5,5 e 5,9 (30%). Para a V% das amostras 9% dos laudos de solo apresentaram valores ≥ 85%, 47% valores de 65 - 74%, 39% valores de 75 a 84%; e apenas 5% destes valores <65%. Praticamente 50% dos laudos das classes texturais 1, 2 e 3 apresentam teores muito alto a alto de P; com 46% dos laudos com teores muito baixo e 21% baixo de P na classe textural 4. Para a CTCpH 7,0 69% dos laudos tiveram CTC média (7,6 – 15 cmolc dm-3) com 100% destas amostras na classe de disponibilidade muito baixo. Nas demais CTCs encontradas a maior frequência dos valores de K ocorreu nas faixas muito alto e alto. Os teores de Ca e Mg tiveram frequência alta (86 e 93%, respectivamente). A MOS apresentou em 93% dos laudos teor médio. Os resultados mostram a necessidade de um cuidado por parte dos produtores e assistência técnica para adequação das doses de nutrientes como o P, Ca e Mg; bem como um cuidado quanto a correção do pH e aumento dos níveis de K em grande parte dos laudos analisados.
Os EXTRATOS VEGETAIS AQUOSOS PARA O TRATAMENTO DE SEMENTES DE CÁRTAMO
Authors: Menegaes Janine Farias , Nunes Ubirajara Russi , Muniz Marlove Fátima Brião , Bellé Rogério Antonio , Zini Priscila Barbieri 
Published: March 2021

O objetivo deste trabalho foi avaliar a qualidade fisiológica e sanitária de sementes de cártamo (Carthamus tinctorius L.) tratadas com diferentes extratos vegetais aquosos. O experimento foi realizado em delineamento inteiramente casualizado, em fatorial 2x10 (dois lotes de sementes e dez combinações de extratos vegetais aquosos e concentrações), com quatro repetições. Os lotes de sementes de cártamo são provientes do campo (Lote A) e da estufa (Lote B), na safra 2016/2017, após serem colhidos foram armazenados em câmara fria, com grau de umidade médio de 9,0%. Os extratos aquosos foram elaborados a partir de folhas de cinamomo (Melia azedarach L.), crisântemo (Dendranthema grandiflora Tzvelev) e tagetes (Tagetes erecta L.), nas concentrações de zero (testemunha), 1%, 5% e 10% na proporção massa/volume (g de folhas frescas 100 mL-1 água destilada). Avaliaram-se as qualidades fisiológica e sanitária pelos testes padrão de germinação, comprimento e massa de plântulas, emergência e sanidade. Conclui-se que a aplicação dos extratos vegetais aquosos como tratamento de sementes de cártamo foi benéfica para o controle patógenos sobre as mesmas, incrementando seu potencial de germinação e de emergência no campo.
دور القياس و العرف لاتمام الادلة الناقصة في الاثبات الجنائي
Authors: Rasul Ahmed B. , Al-Sabhawi Majeed K. 
Published: March 2021

ان المبدأ الاساسي التي تحكم الادلة في الاثبات الجنائي سواء الصعيد الداخلي منها الصعيد الدولي الجنائي هو مبدا الاقتناع القضائي في تكوين قناعته بالنسبة لأي دليل . وهذا المبدأ لا يتحقق الا بوسائل معينة وضمن ضوابط محددة ومن ضمن هذه الوسائل القياس و العرف في استنباط القرينة القضائية لاستكمال اي دليل يعتريه شائبة النقص فان للقاضي الجنائي الاستعانة بتلك الوسائل المذكورة تحقيقا للعدالة الجنائية. ومبدا احقاق الحق ووضع الامور في نصابها وعدم افلات المجرمين من العقاب و الا يدان بريء بجريرة غيره و حسم القضايا بالسرعة الممكنة و تحقيق مبدا القضاء النزيه و العادل مما ينشده القضاة على الصعيدين الداخلي و الدولي
Branched Linguistic Analysis as a Tool for Identifying Attributes Montage’s of Phonograms
Authors: Kaganov A. Sh. 
Published: March 2021

The issues of a branched linguistic analysis of sounding texts for the presence / absence of editing signs or other changes made during the recording process or after its completion on phonograms containing these texts is discussed in the article. The relevance of the work is due to the rapid development of digital technologies for the fixation, analysis and processing of sound (primarily speech) signals and the use of these technologies for the purpose of falsifying phonograms. Particular attention in the work offered to readers is paid to highlighting those theoretical foundations that serve as the basis of the linguistic part of a comprehensive study of sound recordings in relation to their authenticity. The material for the study offered to the readers' attention was a set of sounding texts of those phonograms of Russian speech that were involved in the field of operational-search activity, investigation and legal proceedings as a source of evidence. The author dwells in detail on the issues of a branched linguistic analysis of these texts, consistently analyzes from a theoretical point of view the constituent stages of such a forensic study, shows the role of the linguistic part of the expertise in the integral complex study of sound recordings from the point of view of their integrity.
Digitalisasi Komunikasi Penggiat Backpacker (Studi Kasus Terhadap Komunitas Backpacker)
Authors: Febylia Nadya , Sukendro Gregorius Genep 
Published: March 2021

Along with the times, technology is something that we often encounter around us, including in the world of backpackers. In this digital era, backpakers are divided into two types, namely backpackers who use traveling applications and backpakers who don't. This study aims to determine the positive and negative impacts of digitizing communication on backpacker activists. The formulation of the problem is to determine the positive and negative impacts of new media on the backpacker community, therefore researchers will conduct research on the Jakarta backpacker community. Therefore, the researcher wanted to examine the impact resulting from the use of digital media on the backpacker community by using a qualitative descriptive method and using a phenomenological approach to find out firsthand the experiences of backpacker activists, the research location through zoom from their respective homes. From the results of the research that the researchers have done, the researcher can draw the conclusion that the use of technology in the backpaker world is more positive because the informants whom the researchers interviewed through zoom felt very helped by the current travel applications.Seiring dengan perkembangan zaman, teknologi merupakan sesuatu hal yang sering kita jumpai disekitar kita, termasuk kedalam dunia backpacker. Pada era digital seperti ini, para backpaker menjadi dua tipe yaitu backpacker yang menggunakan aplikasi traveling dan backpaker yang tidak menggunakan aplikasi. Penelitian ini bertujuan untuk mengetahui dampak positif dan dampak negatif dari digitalisasi komunikasi terhadap penggiat backpacker. Rumusan masalahnya adalah untuk mengetahui dampak positif dan dampak negatif dari media baru yang masuk ke dalam komunitas backpacker, oleh karena itu peneliti akan melakukan penelitian terhadap komunitas backpacker Jakarta. Maka dari itu peneliti ingin meneliti tentang dampak yang dihasilkan dari penggunaan media digital terhadap komunitas backpacker dengan menggunakan metode deskriptif kualitatif dan menggunakan pendekatan fenomenologi untuk mengetahui secara langsung pengalaman yang dilakukan oleh para penggiat backpacker, lokasi penelitian melalui zoom dari rumah masing-masing. Dari hasil penelitian yang telah peneliti lakukan, peneliti dapat menarik kesimpulan bahwa penggunaan teknologi pada dunia backpaker lebih mengarah postif karena dari informan yang peneliti wawancarai melalui zoom merasa sangat terbantu dengan aplikasi traveling yang ada saat ini.
Komunikasi Organisasi Komnas Perempuan dalam Menyikapi Penyelesaian Kasus Pelecehan Seksual
Authors: Neoh Gracela , Oktavianti Roswita 
Published: March 2021

Sexual harassment of women often occurs in Indonesia and is disturbing to society. Based on Komnas Perempuan's 2016 Annual Records, there were 16,217 documented cases of sexual harassment. Along with the times, sexual harassment has penetrated into the digital realm, namely one case of sexual harassment in cyberspace that occurred in 2020 by X baristas. The employee uses Closed Circuit Television to peek at the breasts of female customers and spreads through social media. Based on this case, Komnas Perempuan conducted organizational communication by stating that the actions of former X employees included sexual harassment by means of violence by verbally displaying women's bodies without consent. The formulation of the research problem is how Komnas Perempuan's organizational communication is in addressing the resolution of cases of sexual harassment by X baristas. Based on the theoretical study, this research has used organizational communication theory, public relations, and Komnas Perempuan. This research uses descriptive qualitative research methods through case studies by collecting data in the form of interviews, documentation, and literature study. The results of this study, Komnas Perempuan conducted internal communication by suggesting X to restore a safe space and external communication by responding to journalists through groups on instant messaging applications by maintaining a code of ethics to protect victims.Pelecehan seksual kepada kaum perempuan kerap terjadi di Indonesia dan meresahkan masyarakat. Berdasarkan Catatan Tahunan Komnas Perempuan tahun 2016 terdapat 16.217 kasus pelecehan seksual yang berhasil didokumentasikan. Seiring perkembangan zaman, pelecehan seksual merambah ke ranah digital. Salah satu kasus pelecehan seksual di dunia maya terjadi pada tahun 2020 dilakukan oleh barista kafe X. Pegawai tersebut menggunakan kamera pengawas untuk mengintip payudara pelanggan perempuan dan menyebarkan melalui media sosial. Berdasarkan kasus tersebut, Komnas Perempuan melakukan komunikasi organisasi dengan menyatakan tindakan mantan pegawai kafe X tersebut termasuk pelecehan seksual dengan bentuk kekerasan, dengan cara mempertontonkan secara verbal tubuh perempuan tanpa persetujuan. Rumusan masalah penelitian ini yaitu bagaimana komunikasi organisasi Komnas Perempuan dalam menyikapi penyelesaian kasus pelecehan seksual barista X. Penelitian ini menggunakan metode penelitian deskripsif kualitatif melalui studi kasus dengan mengumpulkan data berupa wawancara, dokumentasi, dan studi kepustakaan. Hasil penelitian ini menunjukkan bahwa Komnas Perempuan melakukan komunikasi internal dengan menyarankan perusahaan atau kafe X mengembalikan ruang aman pada pelanggan. Komunikasi eksternal dilakukan dengan memberikan tanggapan kepada wartawan melalui grup pada aplikasi pesan instan. Tanggapan tersebut diberikan dengan tetap menjaga kode etik untuk melindungi korban.
Pengaruh Iklan Goyang Shopee Bersama Cr7 (Cristiano Ronaldo) Terhadap Citra Perusahaan Shopee
Authors: Setiawan Andi , Sari Wulan Purnama 
Published: March 2021

The number of e-commerce companies in Indonesia has encouraged every company including Shopee to create a unique advertisement and can have a good influence on Shopee's corporate image. The research was conducted with the aim to determine the effect of Shake Shopee adverts with Cristiano Ronaldo on Shopee's corporate image. This research uses a quantitative approach with the research method used is descriptive. In this study the authors used survey research methods. The study was conducted by distributing pretest questionnaires to 30 respondents after being tested valid then proceed to the posttest test to 100 respondents who used the Shopee application. The theory used in this research is advertising and imagery. The data validity technique used is the classical regression assumption test, simple linear regression test, correlation analysis, coefficient of determination analysis, and t test. With the t test results show the t value is 9.592> from 1.984, and the results of the correlation test with a value of 0.696 which indicates that advertising and image variables have a strong correlation, so that in this study the results obtained indicate that the advertising function of Shake Shopee ads has an effect on image of Shopee company.Banyaknya perusahaan E-commerce di Indonesia menjadi dorongan setiap perusahaan termasuk Shopee untuk membuat iklan yang unik dan dapat membawa pengaruh baik pada citra perusahaan Shopee. Penelitian dilakukan dengan tujuan untuk mengetahui pengaruh iklan Goyang Shopee bersama Cristiano Ronaldo terhadap citra perusahaan Shopee. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian yang digunakan bersifat deskriptif. Dalam penelitian ini penulis menggunakan metode penelitian survey. Penelitian dilakukan dengan cara menyebarkan kuesioner pretest kepada 30 responden setelah teruji valid kemudian dilanjutkan ke uji posttest kepada 100 responden yang menggunakan aplikasi Shopee. Teori yang digunakan di penelitian ini adalah iklan dan citra. Teknik keabsahan data yang digunakan adalah uji asumsi regresi klasik, uji regresi linier sederhana, analisis korelasi, analisis koefisien determinasi, dan uji t. Dengan hasil uji t menunjukkan nilai t hitung adalah 9,592 > dari 1,984, dan dan hasil uji korelasi dengan nilai 0,696 yang menandakan variabel iklan dan citra memiliki korelasi yang kuat, sehingga dalam penelitian ini hasil yang didapat menunjukkan bahwa fungsi iklan dari iklan goyang Shopee berpengaruh pada citra dari perusahaan Shopee.