bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREDIKSI TINGKAT KEKERUHAN (TURBIDITAS) MENGGUNAKAN CITRA SATELIT SENTINEL-2A DI WADUK JATILUHUR, JAWA BARAT
Authors: Rahman Arip , Astuti Lismining Pujiyani , Warsa Andri , Sentosa Agus Arifin 
Published: November 2021

Turbidity is one of the remote sensing indicators on theÂ reservoir physical characteristics that can reduce its brightness level. Measuring reservoir physical characteristics traditionally are expensive and time consuming as well. Therefore, remote sensing is used as an alternative for turbidity measurement because it can provide data and products spatially, temporally as well as synoptically with low cost. This study aims to obtain an algorithm using a combination of in-situ turbidity data measurement and Sentinel-2A satellite imagery data. The resulting algorithm can be used to predict and map turbidity in Jatiluhur Reservoir. Based on the multiregression between B3 (green band) and B4 (red band) with in-situ turbidity data measurement, it is obtainted that the regression coefficients are a = 76.77, b = 63.22 and c = -34.31 respectively, with the equation of Y = 76, 77+63.22 X1-34.31X2 (Y=predicted turbidity, X1=lnB3, X2=lnB4). The correlation value between in situ and turbidity prediction is quite strong with a coefficient of determination (R2) of 0.60, and Root Mean Square Error (RMSE) of 1.95 NTU. Based on Mean Absolute Percentage Error (MAPE) analysis, the deviation is 31.1%. High levels of turbidity can reduce the main productivity of water and its organisms, especially in respiratory and visual problems. Sedimentation caused by high turbidity levels can make siltation which results in reservoir capacity loss.Keywords: Turbidity, remote sensing, Sentinel-2A satellite imagery data, Jatiluhur Reservoir, siltation
Vladimir Nabokov's Lolita and the Merited-Response Argument
Authors: Głąb Anna 
Published: November 2021

In attempting to answer whether Nabokov’s Lolita can be described as an unethical novel, the author ponders on what basis one could make such a determination. At (1) the author analyzes the merited-response argument offered by Gaut (and previously Hume and Carroll), which provides a conceptual framework for the resolution of the controversy surrounding Lolita. Based on this analysis, (2) the author decides what constitutes the novel’s ethical foundation and what (3) prescriptions and (4) responses can follow from it.
MÁSCARA, MÁSCARAS:
Authors: Teixeira Da Silva Francisco Carlos 
Published: December 2021

Recebido: 15/07/2020
Aprovado: 20/07/2020

Este artigo tem como objetivo analisar de que maneira a novlingua bolsonarista aplica à covid-19 o mesmo molde de padronização que vinha aplicando à caracterização da homossexualidade e da pobreza. Normalizando a violência e naturalizando o desumano, a novlingua bolsonarista é utilizada no cotidiano de tortura e violência sofridas pelos “judeus” do bolsonarismo e na construção do perfil do líder da extrema-direita brasileira. Sendo assim, a partir da violência dispensada aos homossexuais – constituindo um paradigma - e estabelecendo um padrão, é construído o paradigma para a morte por covid-19 no Brasil.
Palavras-chave: Bolsonarismo. Covid-19. Homossexualidade. Novilingua. Pandemia.
The Relationship Between Arterial Stiffness and Helicobacter Pylori Infection
Authors: KAPLAN EFE Fatma , AYBAL KUTLUGÜN Aysun , TEK Müjgan , GÜLER ŞİMŞEK Gülçin , BULUR Oktay , ERGÜN Mustafa Çağrı , ERGÜN Betül 
Published: November 2021

Abstract
Aim:Studies have found the association of Helicobacter Pylori (Hp) seropositivity with cardiovascular diseases and it has been shown that chronic inflammation with Hp may be related to early atherosclerosis. The aim of this study is to evaluate the relationship between Hp positivity detected by endoscopic gastric biopsy and arterial stiffness.
Material and Method: In this cross-sectional study, patients were divided into 2 groups as Hp positive (n=48) and Hp negative (n=61) according to endoscopic gastric biopsy findings. Augmentation index, arterial stiffness and central blood pressure were measured using Pulse wave velocity analysis/Ambulatory blood pressure monitoring in all patients.
Results: Augmentation index was significantly higher in the Hp positive group (p=0.020). There was no correlation between central blood pressure and augmentation index and the intensity of Hp colonization (p=0.070, r=0.263). However, logistic regression analysis revealed that positive Hp (OR: 3.593, 95%CI: 1.341-9,629, p=0.011) was the only variable predictive for an augmentation index > 24.9 among variables including, age, BMI, systolic and diastolic blood pressure, central blood pressure, glucose, creatinine, total cholesterol, C-reactive protein, and positive Hp.
Conclusion: Helicobacter Pylori positive patients with confirmed biopsy have an increased arterial stiffness. Moreover, presence of Hp infection is predictive for an increased arterial stiffness. Regarding the diversity and frequency of Hp worldwide long term follow up studies with larger sample size are needed to elaborate the mechanism of this relationship.
The factor structure of the childbirth self-efficacy inventory in a sample of Turkish pregnant women
Authors: AYDIN Ruveyde , BOSTAN Fatmanur Sena , KUKULU Kamile 
Published: November 2021

ABSTRACT
Aim: Childbirth self-efficacy is very important for the type and management of birth. Women with high self-efficacy prefer vaginal delivery, manage labor pain more easily, need fewer analgesic interventions, and experience fewer complications at birth. This study aimed to examine the factor structure of the Childbirth Self-Efficacy Inventory Short-Version (CBSEI-32) in Turkish pregnant women.
Material and Method: This study was conducted in a methodological design. The sample of the study consisted of the pregnant women admitted to the obstetrics and gynecology outpatient clinic of Karaman State Hospital. The data were collected using the descriptive information form for the pregnant and the CBSEI. Numbers, percentages, arithmetic mean, factor analysis, and Cronbach’s alpha coefficient were used in the data analyses.
Results: As a result of the exploratory factor analysis (EFA), items 6, 12, 13 and 16 in the OE sub-dimension were excluded because their factor load values were below 0.32. And the two-factor structure consisting of 28 items was obtained as the outcome expectancy (OE) and the self-efficacy expectancy (EE). Confirmatory factor analysis (CFA) was performed to obtain additional evidence of construct validity in line with the scores of the scale. It was determined that the fit indices calculated as a result of CFA without any modification were p=0.00, 2/SD; 2.43, GFI=0.90, AGFI=0.90, CFI=0.90, and RMSEA=0.06. The total Cronbach’s alpha reliability coefficient was 0.82.
Conclusion: The study demonstrated that the Turkish version of the “Childbirth Self-Efficacy Inventory” is a valid and reliable tool to measure the childbirth self-efficacy of women during pregnancy.
PERAN DAN MANFAAT KOMUNIKASI PEMBANGUNAN PADA APLIKASI PELACAK COVID-19 SEBAGAI MEDIA KOMUNIKASI KESEHATAN
Authors: KENCANA WORO HARKANDI 
Published: November 2021

Covid-19 telah ditetapkan oleh WHO sebagai pandemi. Penyebaran virus yang sangat cepat di hampir semua negara dunia memberikan perubahan besar pada kehidupan masyarakat. Pemerintah negara khususnya Indonesia membuat berbagai kebijakan untuk mencegah penyebaran virus yang begitu masif ini. Komunikasi kesehatan dilakukan oleh pemerintah melalui berbagi media dalam menyampaikan pesan terkait Covid-19 kepada masyarakat. Salah satu media yang digunakan adalah aplikasi pelacak Covid-19 yang bernama PeduliLindungi.penelitian ini ingin mengetahui bagaimana aplikasi PeduliLindungi ini dalam era digital menjadi media komunikasi kesehatan antara pemerintah dengan masyarakat. Penelitian ini menggunakan pendekatan komunikasi kesehatan dan teori second media age. Metodologi yang digunakan adalah kualitatti deskriptif dengan teknik pengumpulan data berupa wawancara kepada pengguna aplikasi dan observasi terhadap aplikasi PeduliLindungi. Hasil penelitian ini aplikasi PeduliLindungi, merupakan media komunikasi kesehatan mengenai Covid 19 dimana Aplikasi ini mengandalkan partisipasi masyarakat untuk saling membagikan data lokasinya saat bepergian agar penelusuran riwayat kontak dengan penderita COVID-19 dapat dilakukan.aplikasi ini memberikan informasi kesehatan dan protokoler menghadapi pandemi Covid-19. Dengan mengaktifkan aplikasi merupakan gerakan sosial dalam membangun kesadaran dan advokasi penggunaan Internet sebagai sumber berita sebagai kontrol informasi.
De Novo Production of Glycyrrhetic Acid 3-O-mono-β-D-glucuronide in Saccharomyces cerevisiae
Authors: Huang Ying , Jiang Dan , Ren Guangxi , Yin Yan , Sun Yifan , Liu Tengfei , Liu Chunsheng 
Published: November 2021

Glycyrrhetic acid 3-O-mono-β-D-glucuronide (GAMG) is a rare compound in licorice and its short supply limits the wide applications in the pharmaceutical, cosmetic, and food industries. In this study, de novo biosynthesis of GAMG was achieved in engineered Saccharomyces cerevisiae strains based on the CRISPR/Cas9 genome editing technology. The introduction of GAMG biosynthetic pathway resulted in the construction of a GAMG-producing yeast strain for the first time. Through optimizing the biosynthetic pathway, improving the folding and catalysis microenvironment for cytochrome P450 enzymes (CYPs), enhancing the supply of UDP-glucuronic acid (UDP-GlcA), preventing product degradation, and optimizing the fermentation conditions, the production of GAMG was increased from 0.02 μg/L to 92.00 μg/L in shake flasks (4,200-fold), and the conversion rate of glycyrrhetic acid (GA) to GAMG was higher than 56%. The engineered yeast strains provide an alternative approach for the production of glycosylated triterpenoids.
Metagenomic Analysis Reveals the Heterogeneity of Conjunctival Microbiota Dysbiosis in Dry Eye Disease
Authors: Liang Qiaoxing , Li Jing , Zou Yanli , Hu Xiao , Deng Xiuli , Zou Bin , Liu Yu , Wei Lai , Liang Lingyi , Wen Xiaofeng 
Published: December 2021

Background: Dry eye disease (DED) is a multifactorial inflammatory disease of the ocular surface. It is hypothesized that dysbiosis of the conjunctival microbiota contributes to the development of DED. However, species-level compositions of the conjunctival microbiota in DED and the potential dysbiosis involving microorganisms other than bacteria remain largely uncharacterized.Methods: We collected conjunctival impression samples from a cohort of 95 individuals, including 47 patients with DED and 48 healthy subjects. We examined the conjunctival microbiota of these samples using shotgun metagenomic sequencing and analyzed microbial dysbiosis in DED at the species level.Results: The conjunctival microbiota in DED exhibited a decreased α-diversity and an increased inter-individual variation. The α-diversity of female patients with DED was higher than that of male patients. Despite a decreased prevalence in DED, 23 microbial species were identified to show abnormally high abundance in DED samples positive for the species. Among these species, a fungal species Malassezia globosa was enriched female patients. In addition, distinct patterns of associations with disease status were observed for different species of the same genus. For DED subtypes, Staphylococcus aureus and S. capitis were associated with meibomian gland dysfunction (MGD), whereas S. hominis was enriched in patients solely with aqueous tear deficiency (ATD). The microbiota of patients with a mixed type of diagnosis was more similar to MGD patients than ATD patients.Conclusion: We demonstrated that the conjunctival microbiota dysbiosis in DED is characterized by significant heterogeneity. Microbial signatures may offer novel insights into the complicated etiology of DED and potentially promote the development of personalized treatment for DED in the future.
DNA Methylation Signature in Monozygotic Twins Discordant for Psoriatic Disease
Authors: Vecellio Matteo , Paraboschi Elvezia Maria , Ceribelli Angela , Isailovic Natasa , Motta Francesca , Cardamone Giulia , Robusto Michela , Asselta Rosanna , Brescianini Sonia , Sacrini Francesco , Costanzo Antonio , De Santis Maria , Stazi Maria Antonietta , Duga Stefano , Selmi Carlo 
Published: November 2021

Background: Psoriatic disease is a multifactorial inflammatory condition spanning from skin and nail psoriasis (Pso) to spine and joint involvement characterizing psoriatic arthritis (PsA). Monozygotic twins provide a model to investigate genetic, early life environmental exposure and stochastic influences to complex diseases, mainly mediated by epigenetics.Methods: We performed a genome-wide DNA methylation study on whole blood of monozygotic twins from 7 pairs discordant for Pso/PsA using the Infinium Methylation EPIC array (Illumina). MeDiP—qPCR was used to confirm specific signals. Data were replicated in an independent cohort of seven patients with Pso/PsA and 3 healthy controls. Transcriptomic profiling was performed by RNAsequence on the same 7 monozygotic twin pairs.Results: We identified 2,564 differentially methylated positions between psoriatic disease and controls, corresponding to 1,703 genes, 59% within gene bodies. There were 19 regions with at least two DMPs within 1 kb of distance and significant within-pair Δβ-values (p &lt; 0.005), among them SNX25, BRG1 and SMAD3 genes, all involved in TGF-β signaling pathway, were identified. Co-expression analyses on transcriptome data identified IL-6/JAK/STAT3 and TNF-α pathways as important signaling axes involved in the disease, and they also suggested an altered glucose metabolism in patients’ immune cells, characteristic of pro-inflammatory T lymphocytes.Conclusion: The study suggests the presence of an epigenetic signature in affected individuals, pointing to genes involved in immunological and inflammatory responses. This result is also supported by transcriptome data, that altogether suggest a higher activation state of the immune system, that could promote the disease status.
The GW/BSE Method in Magnetic Fields
Authors: Holzer Christof , Pausch Ansgar , Klopper Wim 
Published: November 2021

The GW approximation and the Bethe–Salpeter equation have been implemented into the Turbomole program package for computations of molecular systems in a strong, finite magnetic field. Complex-valued London orbitals are used as basis functions to ensure gauge-invariant computational results. The implementation has been benchmarked against triplet excitation energies of 36 small to medium-sized molecules against reference values obtained at the approximate coupled-cluster level (CC2 approximation). Finally, a spectacular change of colour from orange to green of the tetracene molecule is induced by applying magnetic fields between 0 and 9,000 T perpendicular to the molecular plane.
A Novel Conductive Antibacterial Nanocomposite Hydrogel Dressing for Healing of Severely Infected Wounds
Authors: Xiao Lizhi , Hui Fang , Tian Tenghui , Yan Ruyue , Xin Jingwei , Zhao Xinyu , Jiang Yingnan , Zhang Zhe , Kuang Yulan , Li Na , Zhao Yu , Lin Quan 
Published: November 2021

Wound infections are serious medical complications that can endanger human health. Latest researches show that conductive composite materials may make endogenous/exogenous electrical stimulation more effective, guide/comb cell migration to the wound, and subsequently promote wound healing. To accelerate infected wound healing, a novel medical silver nanoparticle-doped conductive polymer-based hydrogel system (Ag NPs/CPH) dressing with good conductivity, biocompatibility, and mechanical and antibacterial properties was fabricated. For the hydrogel dressing, Ag NPs/CPH, polyvinyl alcohol (PVA), and gelatin were used as the host matrix materials, and phytic acid (PA) was used as the cross-linking agent to introduce conductive polyaniline into the matrix, with antibacterial Ag NPs loaded via impregnation. After a series of analyses, the material containing 5 wt% of PVA by concentration, 1.5 wt% gelatin, 600 μL of AN reactive volume, and 600 μL of PA reactive volume was chosen for Ag NPs/CPH preparation. XPS and FTIR analysis had been further used to characterize the composition of the prepared Ag NPs/CPH. The test on the swelling property showed that the hydrogels had abundant pores with good water absorption (≈140% within 12 h). They can be loaded and continuously release Ag NPs. Thus, the prepared Ag NPs/CPH showed excellent antibacterial property with increasing duration of immersion of Ag NPs. Additionally, to evaluate in vivo safety, CCK-8 experiments of HaCat, LO2 and 293T cells were treated with different concentrations of the Ag NPs/CPH hydrogel soaking solution. The experimental results showed the Ag NPs/CPH had no significant inhibitory effect on any of the cells. Finally, an innovative infection and inflammation model was designed to evaluate the prepared Ag NPs/CPH hydrogel dressing for the treatment of severely infected wounds. The results showed that even when infected with bacteria for long periods of time (more than 20 h), the proposed conductive antibacterial hydrogel could treat severely infected wounds.
Improving the Stability and Activity of Arginine Decarboxylase at Alkaline pH for the Production of Agmatine
Authors: Hong Eun Young , Lee Sun-Gu , Yun Hyungdon , Kim Byung-Gee 
Published: November 2021

Agmatine, involved in various modulatory actions in cellular mechanisms, is produced from arginine (Arg) by decarboxylation reaction using arginine decarboxylase (ADC, EC 4.1.1.19). The major obstacle of using wild-type Escherichia coli ADC (ADCes) in agmatine production is its sharp activity loss and instability at alkaline pH. Here, to overcome this problem, a new disulfide bond was rationally introduced in the decameric interface region of the enzyme. Among the mutants generated, W16C/D43C increased both thermostability and activity. The half-life (T1/2) of W16C/D43C at pH 8.0 and 60°C was 560 min, which was 280-fold longer than that of the wild-type, and the specific activity at pH 8.0 also increased 2.1-fold. Site-saturation mutagenesis was subsequently performed at the active site residues of ADCes using the disulfide-bond mutant (W16C/D43C) as a template. The best variant W16C/D43C/I258A displayed a 4.4-fold increase in the catalytic efficiency when compared with the wild-type. The final mutant (W16C/D43C/I258A) was successfully applied to in vitro synthesis of agmatine with an improved yield and productivity (&gt;89.0% yield based on 100 mM of Arg within 5  h).
Association Between Serum Calcium and the Prevalence of Hypertension Among US Adults
Authors: Hua Yang , Liu Heng-li , Sun Jin-Yu , Kong Xiang-Qing , Sun Wei , Xiong Ya-Qing 
Published: December 2021

Background: Hypertension is a significant risk factor of cardiovascular diseases, posing a serious threat to global health. Calcium plays an important role in regulating body homeostasis. The association of calcium with hypertension remains uncertain in the general population.Methods and Results: Cross-sectional data from the 2007–2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Adjusted multivariable logistic regression analysis and restricted cubic spline were used to investigate the association of serum calcium with the prevalence of hypertension. A total of 26,778 participants were included. The increase in calcium levels showed a positive association with the prevalence of hypertension in all three models with ORs of 1.347 (1.249–1.454), 1.522 (1.401–1.654), and 1.438 (1.306–1.583). The further subgroup analysis demonstrated a robust trend across all categories by sex, age, race, BMI, and eGFR. The restricted cubic spline plot exhibited an S-curve relationship between calcium and hypertension.Conclusion: Our cross-sectional study demonstrated a positive association between higher serum calcium level and the prevalence of hypertension. Our findings highlighted serum calcium level in hypertensive patients.
Influence of Dexmedetomidine on Post-operative Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials
Authors: Peng Sheng , Wang Juan , Yu Hui , Cao Ge , Liu Peirong 
Published: November 2021

Background: Previous clinical studies and meta-analysis evaluating the influence of dexmedetomidine on postoperative atrial fibrillation showed inconsistent results. We performed an updated meta-analysis to evaluate the influence of dexmedetomidine on incidence of postoperative atrial fibrillation after cardiac surgery.Methods: Randomized controlled trials that evaluated the potential influence of dexmedetomidine on the incidence of atrial fibrillation after cardiac surgery were obtained by search of PubMed, Embase, and Cochrane's Library databases from inception to April 12, 2021. A random-effects model incorporating the potential publication bias was used to pool the results. Influences of patient or study characteristics on the efficacy of dexmedetomidine on atrial fibrillation after cardiac surgery were evaluated by meta-regression and subgroup analyses.Results: Fifteen studies with 2,733 patients were included. Pooled results showed that dexmedetomidine significantly reduced the incidence of atrial fibrillation compared to control (OR: 0.72, 95% CI: 0.55–0.94, p = 0.02) with mild heterogeneity (I2 = 26%). Subgroup analysis showed that dexmedetomidine significantly reduced the incidence of atrial fibrillation in studies from Asian countries (OR: 0.41, 95% CI: 0.26–0.66, p &lt; 0.001), but not in those from non-Asian countries (OR: 0.89, 95% CI: 0.71–1.10, p = 0.27; p for subgroup difference = 0.004). Meta-regression analysis showed that the mean age and proportion of male patients may modify the influence of dexmedetomidine on POAF (coefficient = 0.028 and 0.021, respectively, both p &lt; 0.05). Subgroup analysis further showed that Dex was associated with reduced risk of atrial fibrillation after cardiac surgery in studies with younger patients (mean age ≤ 61 years, OR = 0.44, 95% CI: 0.28–0.69, p = 0.004) and smaller proportion of males (≤74%, OR = 0.55, 95% CI: 0.36–0.83, p = 0.005), but not in studies with older patients or larger proportion of males (p for subgroup difference = 0.02 and 0.04).Conclusions: Current evidence supports that perioperative administration of dexmedetomidine may reduce the risk of incidental atrial fibrillation after cardiac surgery, particularly in Asians.