bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common abnormality of gray matter integrity in substance use disorder and obsessive‐compulsive disorder: A comparative voxel‐based meta‐analysis
Authors: Klugah‐Brown Benjamin , Jiang Chenyang , Agoalikum Elijah , Zhou Xinqi , Zou Liye , Yu Qian , Becker Benjamin , Biswal Bharat 
Published: June 2021

AbstractThe objective of the current study is to determine robust transdiagnostic brain structural markers for compulsivity by capitalizing on the increasing number of case‐control studies examining gray matter volume (GMV) alterations in substance use disorders (SUD) and obsessive‐compulsive disorder (OCD). Voxel‐based meta‐analysis within the individual disorders and conjunction analysis were employed to reveal common GMV alterations between SUDs and OCD. Meta‐analytic coordinates and signed brain volumetric maps determining directed (reduced/increased) GMV alterations between the disorder groups and controls served as the primary outcome. The separate meta‐analysis demonstrated that SUD and OCD patients exhibited widespread GMV reductions in frontocortical regions including prefrontal, cingulate, and insular. Conjunction analysis revealed that the left inferior frontal gyrus (IFG) consistently exhibited decreased GMV across all disorders. Functional characterization suggests that the IFG represents a core hub in the cognitive control network and exhibits bidirectional (Granger) causal interactions with the striatum. Only OCD showed increased GMV in the dorsal striatum with higher changes being associated with more severe OCD symptomatology. Together the findings demonstrate robustly decreased GMV across the disorders in the left IFG, suggesting a transdiagnostic brain structural marker. The functional characterization as a key hub in the cognitive control network and casual interactions with the striatum suggest that deficits in inhibitory control mechanisms may promote compulsivity and loss of control that characterize both disorders.
Allogeneic stem cell transplant in non‐Hodgkin lymphomas: Still an indication?
Authors: Dreger Peter 
Published: June 2021

AbstractAllogeneic hematopoietic cell transplantation (alloHCT) used to play a defined role in the treatment of non‐Hodgkin lymphoma (NHL). With the advent of modern targeted molecular therapies and immunotherapies, treatment standards at least for B‐cell lymphoma have undergone significant changes, thereby questioning the traditional role of alloHCT in these diseases. This paper attempts to describe the current place and the perspectives of alloHCT in the rapidly evolving treatment landscape of NHL.
What's new in peripheral T‐cell lymphomas
Authors: Luminari Stefano , Skrypets Tetiana 
Published: June 2021

AbstractPeripheral T‐cell lymphomas (PTCLs) are a rare, heterogeneous group of hematological malignancies with extremely poor prognosis for almost all subtypes. The diverse clinicopathological features of PTCLs make accurate diagnosis, prognosis, and choice of optimal treatment strategies difficult. Moreover, the best therapeutic algorithms are still under debate due to the extrapolated approaches developed for B‐cell lymphomas and to the absence of few treatment protocol specifically developed for PTCLs. Some advances have been made with CD30 monoclonal antibody, mainly for anaplastic large‐cell lymphomas, with improvements in progression‐free survival and overall survival. Several new drugs are under evaluation in clinical trials, although not all the results are as encouraging as expected. In this review, we briefly present the most updated information on diagnosis, prognostication, and treatment strategies in PTCLs.
Langerhans cell histiocytosis: Version 2021
Authors: Gulati Nitya , Allen Carl E. 
Published: June 2021

AbstractChildren with Langerhnans cell histiocytosis (LCH) develop granulomatous lesions with characteristic clonal CD207+ dendritic cells that can arise as single lesions or life‐threatening disseminated disease. Despite the wide range of clinical presentations, LCH lesions are histologically indistinguishable based on severity of disease, and uncertain classification as an immune versus neoplastic disorder has historically challenged the development of optimal clinical strategies for patients with LCH. Recently, activating somatic mutations in MAPK pathway genes, most notably BRAFV600E, have been discovered in almost all cases of LCH. Further, the stage of myeloid differentiation in which the mutation arises defines the extent of disease and risk of developing LCH‐associated neurodegeneration. MAPK activation in LCH precursor cells drives myeloid differentiation, inhibits migration, and inhibits apoptosis, resulting in accumulation of resilient pathologic dendritic cells that recruit and activate T cells. Recurrent somatic mutations in MAPK pathway genes have also been identified in related histiocytic disorders: juvenile xanthogranuloma, Erdheim–Chester disease, and Rosai–Dorfman disease. New insights into pathogenesis support reclassification of these conditions as a myeloid neoplastic disorders. Continued research will uncover opportunities to identify novel targets and inform personalized therapeutic strategies based on cell of origin, somatic mutation, inherited risk factors, and residual disease.
New drugs and pharmacological interactions in real life
Authors: Stathis Anastasios 
Published: June 2021

AbstractA high number of new drugs have entered clinical development and many of them have recently been approved for patients with lymphoid malignancies. The availability of new drugs offers additional treatment options, but it also requires particular attention for the emergence of adverse events. In addition, new drugs may also have interactions with other drugs, which could further increase the risk of toxicities or result in decreased efficacy. Here we review potential drug interactions for nonchemotherapy new drugs approved for patients with lymphoid malignancies.
Statistical analysis on the stratification effects of bioconvective EMHD nanofluid flow past a stretching sheet: Application in theranostics
Authors: Areekara Sujesh , Sabu Alappat Sunny , Mathew Alphonsa , Saravanan Balagangadharan 
Published: June 2021

AbstractCarbon nanotubes (CNTs) are highly recognized for their diverse biomedical applications. The present study aims to numerically and statistically study the stratification effects of bioconvective electromagnetohydrodynamic flow past a stretching sheet using water‐based CNT. The current study, with applications ranging from biomedical imaging, targeted drug delivery, and cancer therapy, provides a theoretical perspective that is beneficial in biomedical engineering. The mathematically modeled system of partial differential equations is then transmuted into a system of ordinary differential equations using apposite transformations, which are then resolved numerically usingbvp5c(MATLAB built‐in function) algorithm. The impacts of influential parameters on concentration, velocity, microbial concentration, temperature, and physical quantities are illustrated with the aid of graphs and tables. Descending electric field parameter and ascending magnetic field parameter retard the velocity profile, which helps in improving the efficiency of targeted drug delivery and biomedical imaging. Further, statistical techniques, like, correlation, the slope of linear regression, probable error, and multiple linear regression, are employed in scrutinizing the consequence of influential parameters on physical quantities and an excellent agreement is observed between the numerical and statistical results. It is noted that the heat transfer rate is positively correlated with electric and magnetic field parameters.
The assessment of representational risk (ARR): Development and psychometric properties of a new coding system for assessing risk in the parent–infant relationship
Authors: Sleed Michelle , Isosävi Sanna , Fonagy Peter 
Published: June 2021

ABSTRACTThere are few clinically valid tools that can be used to assess potential parent–infant relational risk. This study describes the development and initial validation of the assessment of representational risk (ARR) coding system to be applied to the parent development interview (Slade, A., Aber, J. L., Bresgi, I., Berger, B., & Kaplan, M. (2004). The Parent Development Interview – Revised. Unpublished protocol. New York, NY: The City University of New York.) for assessing potential risk in caregivers’ representations of their infant, themselves as parents, and their relationship. The ARR was developed and validated in three samples in England. A review of the literature informed the selection of 10 items. It had a three‐factor structure that was used to inform subscales: hostile, helpless, and narcissistic caregiving representations. The subscales and total risk scores showed good criterion validity for discriminating between high and low risk samples and good concurrent validity with measures of parental psychopathology and parent–infant interaction. The ARR is a potentially valuable coding system for identifying risk in early attachment relationships.
A flexible metallic TiC nanofiber/vertical graphene 1D/2D heterostructured as active electrocatalyst for advanced Li–S batteries
Authors: Zhang Yongshang , Zhang Peng , Zhang Shijie , Wang Zheng , Li Neng , Silva S. Ravi P. , Shao Guosheng 
Published: June 2021

AbstractThe realistic application of lithium–sulfur (Li–S) batteries has been severely hindered by the sluggish conversion kinetics of polysulfides (LiPS) and inhomogeneous deposition of Li2S at high sulfur loading and low electrolyte/sulfur ratio (E/S). Herein, a flexible Li–S battery architecture based on electrocatalyzed cathodes made of interfacial engineered TiC nanofibers and in situ grown vertical graphene are developed. Integrated 1D/2D heterostructured electrocatalysts are realized to enable highly improved Li+ and electron transportation together with significantly enhanced affinity to LiPS, which effectively accelerate the conversion kinetics between sulfur species, and thus induce homogeneous deposition of Li2S in the catalyzed cathodes. Consequently, highly active electro‐electrocatalysts‐based cells exhibit remarkable rate capability at 2C with a high specific capacity of 971 mAh g−1. Even at ultra‐high sulfur loading and low E/S ratio, the battery still delivers a high areal capacity of 9.1 mAh cm−2, with a flexible pouch cell being demonstrated to power a LED array at different bending angles with a high capacity over 100 cycles. This work puts forward a novel pathway for the rational design of effective nanofiber electrocatalysts for cathodes of high‐performance Li–S batteries.
Platelet and leukocyte count assay for thrombogenicity screening of biomaterials and medical devices: Evaluation and improvement of ASTM F2888 test standard
Authors: Lu Qijin , Nehrer Joshua M. , Li Jiaming , Jamiolkowski Megan A. , Rinaldi Jean E. , Malinauskas Richard A. 
Published: June 2021

AbstractAn appropriate preclinical thrombogenicity evaluation of a blood‐contacting device is important to reduce thrombosis and thromboembolism risks to patients. The in vitro platelet and leukocyte count assay, as described in the ASTM F2888 test standard, aims to assess thrombogenic potentials of blood‐contacting materials. The goals of this study were to evaluate whether this standardized test method can effectively differentiate materials with different thrombogenic potentials and to investigate the impact of anticoagulation conditions on test sensitivity. Using human blood with various anticoagulation conditions, we performed the platelet and leukocyte count assays on four biomaterials and three positive control materials. We found that the use of sodium citrate anticoagulation as stipulated in the 2013 version of the ASTM F2888 standard cannot differentiate materials with different thrombogenic potentials. The modification to use low‐concentration heparin, either with recalcified citrated blood or with direct heparinization, substantially improved the test sensitivity and enabled the assay to distinguish platelet count reduction between the positive controls and commonly used biomaterials. Leukocyte count was shown to be a much less sensitive indicator than platelet count for thrombogenicity evaluations of biomaterials. The findings from this study have been incorporated in the recent 2019 version of the ASTM F2888 standard.
Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies
Authors: Yu Xing-Hao , Wei Yong-Yue , Zeng Ping , Lei Shu-Feng 
Published: June 2021

ABSTRACTThe relationship between birth weight and osteoporosis was inconsistent in previous observational studies. Therefore, we performed a systematic evaluation to determine the inconsistent relationship and further make causal inference based on the UK Biobank datasets (~500,000 individuals) and individual/summary-level genetic datasets. Observational analyses found consistent negative associations either between birth weight and estimated bone mineral density (eBMD) or between genetic risk score (GRS) of birth weight and eBMD in total subjects, and sex-stratified subgroups. Mediation analyses detected significant mediation effects of adult weight and height on associations between birth weight and eBMD. Birth weight was causally associated not only with three BMD phenotypes (eBMD, total body [TB]-BMD, and femoral neck [FN]-BMD) under two effect models (total and fetal effect), but also with the risk of fracture using different Mendelian randomization (MR) methods. Multivariable MR analyses detected the pleiotropic effects of some environmental factors (e.g., gestational duration, head circumference, hip circumference) on the associations between birth weight and BMD/fracture. Three BMD phenotypes (eBMD, TB-BMD, and FN-BMD) have significant mediation effects on the associations between birth weight and fracture by using a novel mediation MR analysis under the multivariable MR framework. This multistage systematic study found consistent causal associations between birth weight and osteoporosis risk, fetal origin of genetic effects underlying the associations, and several mediation factors on the detected associations. The results enhanced our understanding of the effects of fetal original phenotypes on outcomes in late adulthood and provided helpful clues for early prevention research on osteoporosis. © 2021 American Society for Bone and Mineral Research (ASBMR).
Dmp1Cre-directed knockdown of parathyroid hormone–related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny
Authors: Ansari Niloufar , Isojima Tsuyoshi , Crimeen-Irwin Blessing , Poulton Ingrid J. , McGregor Narelle E. , Ho Patricia W. M. , Forwood Mark R. , Kovacs Christopher S. , Dimitriadis Evdokia , Gooi Jonathan H. , Martin T. John , Sims Natalie A. 
Published: June 2021

ABSTRACT
Parathyroid hormone–related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre-targeted PTHrP deletion in osteocytes causes osteopenia and impaired cortical strength. We report here that this outcome depends on parental genotype. In contrast to our previous report using mice bred from heterozygous (flox/wild type) Dmp1Cre.Pthlhf/w parents, adult (16-week-old and 26-week-old) flox/flox (f/f) Dmp1Cre.Pthlhf/f mice from homozygous parents (Dmp1Cre.Pthlhf/f(hom)) have stronger bones, with 40% more trabecular bone mass and 30% greater femoral width than controls. This greater bone size was observed in Dmp1Cre.Pthlhf/f(hom) mice as early as 12 days of age, when greater bone width was also found in male and female Dmp1Cre.Pthlhf/f(hom) mice compared to controls, but not in gene-matched mice from heterozygous parents. This suggested a maternal influence on skeletal size prior to weaning. Although Dmp1Cre has previously been reported to cause gene recombination in mammary gland, milk PTHrP protein levels were normal. The wide-bone phenotype was also noted in utero: Dmp1Cre.Pthlhf/f(hom) embryonic femurs were more mineralized and wider than controls. Closer examination revealed that Dmp1Cre caused PTHrP recombination in placenta, and in the maternal-derived decidual layer that resides between the placenta and the uterus. Decidua from mothers of Dmp1Cre.Pthlhf/f(hom) mice also exhibited lower PTHrP levels by immunohistochemistry and were smaller than controls. We conclude that Dmp1Cre leads to gene recombination in decidua, and that decidual PTHrP might, through an influence on decidual cells, limit embryonic bone radial growth. This suggests a maternal-derived developmental origin of adult bone strength. © 2021 American Society for Bone and Mineral Research (ASBMR).
Synthesis and application of recyclable core‐shell structure microspheres MCTS‐g‐AT in detection of Hg(II) in aquatic products
Authors: Wang Xiaoqing , Zhang Jing , Xu Zimeng , Rao Chen , Pi Leilei , Fu Yaqin , Dong Yubing , Shen Chen , Yao Lanying , Xiong Chunhua 
Published: June 2021

AbstractThe MCTS‐g‐AT was developed as a novel magnetic adsorbent with core‐shell structure. Its unique synthesis route endows MCTS‐g‐AT with green, convenient, economical and safe characteristics, and also good selective adsorption of Hg(II). The material was characterized using an appropriate set of spectroscopic and analytical techniques (SEM, EDS, XRD, VSM, FTIR, and TGA). Its adsorption kinetics fits the pseudo‐secondary model well and adsorption isotherm fits the Langmuir equation well, suggesting the mechanism of chemisorption with monolayer adsorption. The results of the thermodynamic parameters indicate spontaneous and endothermic process. Column adsorption experiments showed that the maximum adsorption capacity of Hg(II) was 207.6 mg/g (298 K). Moreover, the Hg(II) adsorbed on composite microspheres was completely eluted by 3 mol/L HNO3 or 4 mol/L HCl. Furthermore, MCTS‐g‐AT adsorption column combined with spectrophotometer can achieve more accurate detection of Hg(II) in aquatic products.
Analysis of the diagnostic capabilities of urinary neutrophil gelatinase‐associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission
Authors: Imoto Yuji , Wakasaki Ayano , Izumida Kumiko , Shimada Hiroshi , Ohkubo Kumiko , Kawano Yasumasa , Ishikura Hiroyasu , Matsunaga Akira 
Published: June 2021

AbstractBackgroundAcute kidney injury (AKI) is a disease that negatively affects patient prognosis and requires early diagnosis and treatment. Biomarkers that predict AKI are needed for early diagnosis of this disease.MethodsWe compared the AKI group and the non‐AKI group in patients who were admitted to our critical care intensive care unit (ICU) and conducted a comparative study focusing on urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) and serum procalcitonin (PCT).ResultsSeventy‐one out of 106 ICU inpatients were diagnosed with AKI in accordance with the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Among the patients who were diagnosed with AKI stages 1 to 3, 94.4% of all patients reached the maximum stage by day 5 after admission. Comparing the non‐AKI group and AKI stage 1 to 3 on days 1 to 3 after admission, U‐NGAL and PCT levels in the stage 3 group were significantly higher than those in the non‐AKI group. Additionally, in receiver operating characteristic curve (ROC) analysis on days 1–3 after admission, U‐NGAL and PCT levels can be used as biomarkers for the diagnosis of AKI, and in particular, AKI stage 3 can be predicted and diagnosed with high accuracy. U‐NGAL and PCT levels were also significantly higher in AKI due to sepsis and acute pancreatitis and due to sepsis, respectively.ConclusionsMeasuring U‐NGAL and PCT levels as biomarkers for AKI may further improve the accuracy of AKI diagnosis in critical care ICU.
Association between preoperative lipid profiles and new‐onset diabetes after transplantation in Chinese kidney transplant recipients: A retrospective cohort study
Authors: Ye Yangli , Gao Jian , Liang Jing , Yang Yinqiu , Lv Chaoyang , Chen Minling , Wang Jina , Zhu Dong , Rong Ruiming , Xu Ming , Zhu Tongyu , Yu Mingxiang 
Published: June 2021

AbstractBackgroundThis study investigated the association between the preoperative lipid profiles and new‐onset diabetes after transplantation (NODAT) in Chinese kidney transplant recipients (KTRs).MethodsIn this study, of 1140 KTRs registered between January 1993 and March 2018 in Zhongshan Hospital, Fudan University, 449 were enrolled. Clinical data, obtained through a chart review of the patient records in the medical record system, were evaluated, and NODAT was diagnosed based on the American Diabetes Association guidelines. Multivariate Cox regression analysis was conducted to determine whether the preoperative lipid profiles in KTRs were independently associated with NODAT incidence. The preoperative lipid profiles were analyzed as continuous variables and grouped into tertiles. Smooth curve fitting was used to confirm the linear associations.ResultsDuring a median follow‐up of 28.03 (interquartile range 12.00–84.23) months, 104 of the 449 (23.16%) participants developed NODAT. The multivariate model analysis, adjusted for all potential covariates, showed that increased values of the following parameters were associated with NODAT (hazard ratio, 95% confidence interval): preoperative total cholesterol (TC; 1.25, 1.09–1.58, p = 0.0495), low‐density lipoprotein cholesterol (LDL‐C; 1.33, 1.02–1.75, p = 0.0352), non‐high‐density lipoprotein cholesterol (non‐HDL‐C; 1.41, 1.09–1.82, p = 0.0084), TC/HDL‐C (1.28, 1.06–1.54, p = 0.0109), and non‐HDL‐C/HDL‐C (1.26, 1.05–1.52, p = 0.0138). However, the association between the preoperative triglyceride, HDL‐C, or TG/HDL‐C and NODAT was not significant.ConclusionsPreoperative TC, LDL‐C, non‐HDL‐C, TC/HDL‐C, and non‐HDL‐C/HDL‐C were independent risk factors for NODAT.
“I wanted to do more of the homework!”—Feasibility and acceptability of blending app‐based homework with group therapy for social cognition in psychosis
Authors: Sedgwick Ottilie , Hardy Amy , Greer Ben , Newbery Katie , Cella Matteo 
Published: June 2021

AbstractObjectivesEvidence suggests social‐cognitive difficulties are linked to poor community functioning in people with psychosis, however, there is limited evidence that social‐cognition interventions improve functioning. This may be due to poor generalization of therapy learning; digital technologies may be useful to support this. This study evaluates the feasibility of a brief, blended intervention (group therapy plus app) for individuals with psychosis.MethodsA total of 14 clients diagnosed with psychosis‐spectrum difficulties participated. Feasibility was assessed by referral, adherence and completion rates, and acceptability via semi‐structured interview (thematically analyzed).ResultsThe procedures were considered feasible and acceptable. The face‐to‐face component of the intervention was particularly valued, and participants reported benefits to their daily lives. The app was experienced as helpful, alongside some difficulties.ConclusionsDevelopment of blended interventions may prove an important avenue to maximize the adherence and reach of psychological interventions. The results of this study reinforce the need to maintain face‐to‐face components alongside digital.