bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of hyperspectral remote sensing for supplementary investigation of polymetallic deposits in Huaniushan ore region, northwestern China
Authors: Wan Yu-qing , Fan Yu-hai , Jin Mou-shun 
Published: January 2021

AbstractA gold–silver–lead–zinc polymetallic ore was selected in Huaniushan, Gansu Province as the study area. Hyperspectral aerial images as the primary information source, ground spectrum tests, and sampling analysis were used as auxiliary techniques. They were combined with large-scale mineral and geological maps and other high-resolution satellite remote sensing images. Hyperspectral remote sensing classification identification and quantitative analysis methods were used to study the main mineral resources and rock mass occurrence. Finally, deposit distribution information was extracted and validated. The results showed that the effective classification methods by hyperspectral images were spectral angle mapping, minimum noise fraction transform, and mixed tuned matched filtering. Based on the ground survey, combined with sampling analysis, the accuracy of classification was 80%. The recognition rate of the main ore body—the iron-manganese cap lead–zinc oxide ore—was as high as 81%. This research showed that hyperspectral remote sensing in this mining area has excellent demonstration effects and is worth completing and supplementing original mineral and geological maps. The targets are important areas for detailed follow-up on mineral resource exploration.
Canadian undergraduate men’s visual attention to cisgender women, cisgender men, and feminine trans individuals
Authors: Petterson Lanna J. , Vasey Paul L. 
Published: January 2021

AbstractSome heterosexual men express sexual interest in feminine trans individuals with penises. It is possible that this interest arises from a tendency for heterosexual men to be sexually responsive to gender in addition to sex. We compared the self-reported sexual attraction and visual attention patterns of Canadian undergraduate heterosexual men (N = 51) and gay men (N = 20) to nude images of feminine trans individuals with penises, cisgender men, and cisgender women. Heterosexual men were most attracted to cisgender women and fixated on them the longest. However, they were more attracted to feminine trans individuals with penises than to cisgender men. They also biased their attention to feminine trans individuals with penises over cisgender men. This pattern was unique to heterosexual men. Gay men were most attracted to cisgender men and allocated the most visual attention to them. They responded to feminine trans individuals and cisgender women in a relatively similar manner. As such, heterosexual men appear to be responsive to sex and gender, which may account for sexual interest in feminine trans individuals among some heterosexual men.
The interaction between self-care behavior and disease knowledge on the decline in renal function in chronic kidney disease
Authors: Tsai Yi-Chun , Wang Shu-Li , Tsai Hui-Ju , Chen Tzu-Hui , Kung Lan-Fang , Hsiao Pei-Ni , Hsiao Shih-Ming , Hwang Shang-Jyh , Chen Hung-Chun , Chiu Yi-Wen 
Published: January 2021

AbstractMultidisciplinary care can improve the outcomes of chronic kidney disease (CKD), however the contribution of self-care behavior and knowledge about CKD is unclear. This study enrolled 454 participants with CKD stages 1–5 not on dialysis. Structured questionnaires were used to evaluate self-care behavior and kidney disease knowledge. Rapid decline in renal function was defined as the decline in estimated filtration rate > 3 ml/min per 1.73 m2/year within 1-year prior to enrollment. The mean age of all study participants was 65.8 ± 12.1 years and 55.9% were male. The elderly had better self-care behavior while younger participants had better disease knowledge. Both high self-care and high disease knowledge scores were significantly associated with and had a synergistic effect on decreasing the risk of rapid decline in renal function. CKD patients with better self-care behavior and better kidney disease knowledge had lower risk of rapid decline in renal function.
GVES: machine learning model for identification of prognostic genes with a small dataset
Authors: Ko Soohyun , Choi Jonghwan , Ahn Jaegyoon 
Published: January 2021

AbstractMachine learning may be a powerful approach to more accurate identification of genes that may serve as prognosticators of cancer outcomes using various types of omics data. However, to date, machine learning approaches have shown limited prediction accuracy for cancer outcomes, primarily owing to small sample numbers and relatively large number of features. In this paper, we provide a description of GVES (Gene Vector for Each Sample), a proposed machine learning model that can be efficiently leveraged even with a small sample size, to increase the accuracy of identification of genes with prognostic value. GVES, an adaptation of the continuous bag of words (CBOW) model, generates vector representations of all genes for all samples by leveraging gene expression and biological network data. GVES clusters samples using their gene vectors, and identifies genes that divide samples into good and poor outcome groups for the prediction of cancer outcomes. Because GVES generates gene vectors for each sample, the sample size effect is reduced. We applied GVES to six cancer types and demonstrated that GVES outperformed existing machine learning methods, particularly for cancer datasets with a small number of samples. Moreover, the genes identified as prognosticators were shown to reside within a number of significant prognostic genetic pathways associated with pancreatic cancer.
Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions
Authors: Ishikawa Takuya , Kawashima Hiroki , Ohno Eizaburo , Iida Tadashi , Suzuki Hirotaka , Uetsuki Kota , Yashika Jun , Yamada Kenta , Yoshikawa Masakatsu , Gibo Noriaki , Aoki Toshinori , Kataoka Kunio , Mori Hiroshi , Yamamura Takeshi , Furukawa Kazuhiro , Nakamura Masanao , Hirooka Yoshiki , Fujishiro Mitsuhiro 
Published: January 2021

AbstractAutoimmune pancreatitis (AIP) is recognized as the pancreatic manifestation of a systemic IgG4-related disease that can involve various organs, including the kidney. However, renal lesions tend to be overlooked when AIP is diagnosed, and the clinical characteristics and long-term prognosis of AIP with renal lesions are unclear. We retrospectively reviewed 153 patients with AIP diagnosed at our hospital with a median follow-up period of 41 months (interquartile range, 10–86) and classified them into two groups: the KD group (n = 17), with characteristic renal imaging features, and the non-KD group (n = 136). Serum IgG4 levels were significantly higher in the KD group (663 vs. 304.5 mg/dl, P = 0.014). No differences were observed between the two groups in terms of steroid treatment [14/17 (82.4%) vs. 112/136 (82.4%), P = 1] or in the number of patients who exhibited exacerbation of renal function during treatment [1/17 (5.9%) vs. 8/136 (5.9%), P = 1]. However, the cumulative relapse rate was significantly higher in the KD group [61% vs. 21.9% (3 years), P < 0.001]. Patients in the KD group had different clinical features with high relapse rates compared with those in the non-KD group, and thus, it is important to confirm the presence of renal lesions in AIP patients.
Awareness of voluntary action, rather than body ownership, improves motor control
Authors: Matsumiya Kazumichi 
Published: January 2021

AbstractAwareness of the body is essential for accurate motor control. However, how this awareness influences motor control is poorly understood. The awareness of the body includes awareness of visible body parts as one’s own (sense of body ownership) and awareness of voluntary actions over that visible body part (sense of agency). Here, I show that sense of agency over a visible hand improves the initiation of movement, regardless of sense of body ownership. The present study combined the moving rubber hand illusion, which allows experimental manipulation of agency and body ownership, and the finger-tracking paradigm, which allows behavioral quantification of motor control by the ability to coordinate eye with hand movements. This eye–hand coordination requires awareness of the hand to track the hand with the eye. I found that eye–hand coordination is improved when participants experience a sense of agency over a tracked artificial hand, regardless of their sense of body ownership. This improvement was selective for the initiation, but not maintenance, of eye–hand coordination. These results reveal that the prospective experience of explicit sense of agency improves motor control, suggesting that artificial manipulation of prospective agency may be beneficial to rehabilitation and sports training techniques.
Self-diffusion in garnet-type Li7La3Zr2O12 solid electrolytes
Authors: Kuganathan Navaratnarajah , Rushton Michael J. D. , Grimes Robin W. , Kilner John A. , Gkanas Evangelos I. , Chroneos Alexander 
Published: January 2021

AbstractTetragonal garnet-type Li7La3Zr2O12 is an important candidate solid electrolyte for all-solid-state lithium ion batteries because of its high ionic conductivity and large electrochemical potential window. Here we employ atomistic simulation methods to show that the most favourable disorder process in Li7La3Zr2O12 involves loss of Li2O resulting in lithium and oxygen vacancies, which promote vacancy mediated self-diffusion. The activation energy for lithium migration (0.45 eV) is much lower than that for oxygen (1.65 eV). Furthermore, the oxygen migration activation energy reveals that the oxygen diffusion in this material can be facilitated at higher temperatures once oxygen vacancies form.
Topologically distinct Weyl fermion pairs
Authors: Hsu Ming-Chien , Lin Hsin , Hasan M. Zahid , Huang Shin-Ming 
Published: January 2021

AbstractA Weyl semimetal has Weyl nodes that always come in pairs with opposite chiralities. Notably, different ways of connection between nodes are possible and would lead to distinct topologies. Here we identify their differences in many respects from two proposed models with different vorticities. One prominent feature is the behaviour of zeroth Landau levels (LLs) under magnetic field. We demonstrate that the magnetic tunneling does not always expel LLs from zero energy because the number of zero-energy modes is protected by the vorticity of the Weyl nodes, instead of the chirality. Other respects in disorder effects for weak (anti-)localization, surface Fermi arcs, and Weyl-node annihilation, are interesting consequences that await more investigation in the future.
The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease
Authors: Demandt J. A. F. , Dubois L. J. , van Kuijk K. , Zaťovičová M. , Jin H. , Parkkila S. , van der Laan S. W. , Jelenska L. , Mees B. M. E. , Reutelingsperger C. P. M. , Cleutjens K. B. J. M. , van der Kallen C. J. H. , Schalkwijk C. G. , van Greevenbroek M. M. J. , Biessen E. A. L. , Pasterkamp G. , Pastoreková S. , Stehouwer C. D. A. , Sluimer J. C. 
Published: January 2021

AbstractHypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic anhydrase IX (CAIX) is hypoxia-induced and can be shed into the circulation as soluble CAIX (sCAIX). As plaque macrophages are hypoxic, we hypothesized a role for CAIX in macrophage function, and as biomarker of hypoxic plaque burden and CVD. As tumor patients with probable CVD are treated with CAIX inhibitors, this study will shed light on their safety profile. CAIX co-localized with macrophages (CD68) and hypoxia (pimonidazole), and correlated with lipid core size and pro-inflammatory iNOS+ macrophages in unstable human carotid artery plaques. Although elevated pH and reduced lactate levels in culture medium of CAIX knock-out (CAIXko) macrophages confirmed its role as pH-regulator, only spare respiratory capacity of CAIXko macrophages was reduced. Proliferation, apoptosis, lipid uptake and expression of pro- and anti-inflammatory genes were not altered. Plasma sCAIX levels and plaque-resident CAIX were below the detection threshold in 50 and 90% of asymptomatic and symptomatic cases, respectively, while detectable levels did not associate with primary or secondary events, or intraplaque hemorrhage. Initial findings show that CAIX deficiency interferes with macrophage metabolism. Despite a correlation with inflammatory macrophages, plaque-resident and sCAIX expression levels are too low to serve as biomarkers of future CVD.
Rapid processing of fearful faces relies on the right amygdala: evidence from individuals undergoing unilateral temporal lobectomy
Authors: Framorando David , Moses Eleanor , Legrand Lore , Seeck Margitta , Pegna Alan J. 
Published: January 2021

AbstractFacial expressions of emotions have been shown to modulate early ERP components, in particular the N170. The underlying anatomical structure producing these early effects are unclear. In this study, we examined the N170 enhancement for fearful expressions in healthy controls as well as epileptic patients after unilateral left or right amygdala resection. We observed a greater N170 for fearful faces in healthy participants as well as in individuals with left amygdala resections. By contrast, the effect was not observed in patients who had undergone surgery in which the right amygdala had been removed. This result demonstrates that the amygdala produces an early brain response to fearful faces. This early response relies specifically on the right amygdala and occurs at around 170 ms. It is likely that such increases are due to a heightened response of the extrastriate cortex that occurs through rapid amygdalofugal projections to the visual areas.
In-vivo measurement of the fluorescence spectrum of wild cochineal (Dactylopius opuntiae)
Authors: Cárdenas Rosales Alejandra , Delgado Atencio José Alberto , Cunill Rodríguez Margarita , González Gutiérrez Enrique 
Published: January 2021

AbstractIt is known that the harmful presence of the wild cochineal (Dactylopius opuntiae), unlike the fine cochineal (Dactylopius coccus), in prickly pear crops of farmers leads to consider it as one of the major pests for this crop. In this study, we present the implementation of an optical setup that ensures the measurement of the in-vivo fluorescence spectra of wild cochineals ranging in size from 440 to 1190 µm in their natural habitat achieved by developing a reproduction model adopted from available literature. It was observed that in-vivo fluorescence spectra of these insects were comprised in the spectral region of 570–760 nm, showing a proportional dependence between the fluorescence intensity emitted and the cochineal size. In addition, we have considered other spectral parameters to perform the comparison between fluorescence spectra of the different cochineal sizes. These results provide the basis for the development of novel methodologies and equipment aimed towards the early detection of this pest in prickly pear crops from its early growth stages (nymph I and II).
Gut microbiota dynamics in carnivorous European seabass (Dicentrarchus labrax) fed plant-based diets
Authors: Serra Cláudia R. , Oliva-Teles Aires , Enes Paula , Tavares Fernando 
Published: January 2021

AbstractA healthy gastrointestinal microbiota is essential for host fitness, and strongly modulated by host diet. In aquaculture, a current challenge is to feed carnivorous fish with plant-feedstuffs in substitution of fish meal, an unsustainable commodity. Plants have a limited nutritive value due to the presence of non-starch polysaccharides (NSP) which are not metabolized by fish. In this work we assessed the effects of NSP-enriched diets on European seabass gut microbiota and evaluate the selective pressure of plant feedstuffs towards gut microbes with NSP-hydrolytic potential, i.e. capable to convert indigestible dietary constituents in fish metabolites. Triplicate groups of European seabass juveniles were fed a fish meal-based diet (control) or three plant-based diets (SBM, soybean meal; RSM, rapeseed meal; SFM, sunflower meal) for 6 weeks, before recovering intestinal samples for microbiota analysis, using the Illumina’s MiSeq platform. Plant-based diets impacted differently digesta and mucosal microbiota. A decrease (p = 0.020) on species richness, accompanied by a decline on the relative abundance of specific phyla such as Acidobacteria (p = 0.030), was observed in digesta samples of SBM and RSM experimental fish, but no effects were seen in mucosa-associated microbiota. Plant-based diets favored the Firmicutes (p = 0.01), in particular the Bacillaceae (p = 0.017) and Clostridiaceae (p = 0.007), two bacterial families known to harbor carbohydrate active enzymes and thus putatively more prone to grow in high NSP environments. Overall, bacterial gut communities of European seabass respond to plant-feedstuffs with adjustments in the presence of transient microorganisms (allochthonous) with carbohydrolytic potential, while maintaining a balanced core (autochthonous) microbiota.
Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
Authors: Kim Jung A. , Hwang Soon Young , Yu Ji Hee , Roh Eun , Hong So-hyeon , Lee You-Bin , Kim Nam Hoon , Yoo Hye Jin , Seo Ji A. , Kim Nan Hee , Kim Sin Gon , Baik Sei Hyun , Choi Kyung Mook 
Published: January 2021

AbstractThe triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 years from the Korea National Health and Nutrition Examination Survey between 2008 and 2011. The TyG index was calculated as ln[triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Dual-energy X-ray absorptiometry was used to measure appendicular lean mass (ALM). Low muscle mass was defined an ALM/weight of 2 standard deviations (SD) below of young participants. The overall prevalence of low muscle mass was 4.7%. The prevalence of low muscle mass increased linearly with the quartiles of the TyG index, 2.5%, 4.2%, 5.6%, and 6.7% in Q1–Q4, respectively. The TyG index was negatively associated with ALM/weight both in men (r = − 0.302) and women (r = − 0.230). The odds ratio (OR) for low muscle mass was 2.08 in the highest quartile compared to the lowest quartile. High TyG index was associated with an increased risk of low muscle mass (OR for 1SD increase: 1.13). Increased TyG index was associated with the risk of low muscle mass independent of confounding factors.
Prevalence, infection intensity and geographical distribution of schistosomiasis among pre-school and school aged children in villages surrounding Lake Nyasa, Tanzania
Authors: Mazigo Humphrey Deogratias , Uisso Cecilia , Kazyoba Paul , Nshala Andreas , Mwingira Upendo J. 
Published: January 2021

AbstractPlanning and implementation of schistosomiasis control activities requires an understanding of the prevalence, intensity of infection and geographical distribution of the disease in different epidemiological settings. Although, Tanzania is known to be highly endemic to schistosomiasis, there is paucity of data on the geographical distribution of schistosomiasis in potential large water bodies in the country. Thus, the present study was conducted to determine the prevalence, infection intensities and geographical distribution of schistosomiasis along villages located on the shoreline of Lake Nyasa, southern Tanzania. A cross-sectional study was conducted among 1560 children aged 1–13 years old living in villages located along the shoreline of Lake Nyasa. A single urine and stool sample was obtained from each participating child and screened for S.mansoni using Kato Katz (KK) technique to detect eggs and using point-of-care circulating Cathodic Antigen (POC-CCA) test to detect antigen in urine. Urine filtration technique was used to screen for S.haematobium eggs in urine samples. Villages/primary school were mapped using geographical information system and prevalence map was generated using ArcView GIS software. The overall prevalence of S.mansoni based on KK technique and POC-CCA test was 15.1% (95%CI: 13.4–16.9) and 21.8% (95%CI: 18.5–25.3) respectively. The prevalence S.haematobium was 0.83% (95%CI: 0.5–1.4) and that of haematuria was 0.9%. The arithmetic mean egg intensities for S.haematobium and S.mansoni were 18.5 mean eggs/10 ml (95%CI: 5.9–57.6) of urine and 34.7 mean epg (95%CI: 27.7–41.7) respectively. Villages located on the southern end of the lake had significantly high prevalence of S.mansoni than those located on the northern part (χ2 = 178.7838, P = 0.001). Cases of S.haematobium were detected only in three villages. Both S.mansoni and S.haematobium infections occur in villages located along the shoreline of Lake Nyasa at varying prevalence. These finding provide insights that can provide guidance in planning and implementation of MDA approach and other recommended measures such as improvement in sanitation, provision of clean water and behaviour changes through public health education.
Mitochondrial gene expression in single cells shape pancreatic beta cells' sub-populations and explain variation in insulin pathway
Authors: Medini H. , Cohen T. , Mishmar D. 
Published: January 2021

AbstractMitochondrial gene expression is pivotal to cell metabolism. Nevertheless, it is unknown whether it diverges within a given cell type. Here, we analysed single-cell RNA-seq experiments from human pancreatic alpha (N = 3471) and beta cells (N = 1989), as well as mouse beta cells (N = 1094). Cluster analysis revealed two distinct human beta cells populations, which diverged by mitochondrial (mtDNA) and nuclear DNA (nDNA)-encoded oxidative phosphorylation (OXPHOS) gene expression in healthy and diabetic individuals, and in newborn but not in adult mice. Insulin gene expression was elevated in beta cells with higher mtDNA gene expression in humans and in young mice. Such human beta cell populations also diverged in mitochondrial RNA mutational repertoire, and in their selective signature, thus implying the existence of two previously overlooked distinct and conserved beta cell populations. While applying our approach to human alpha cells, two sub-populations of cells were identified which diverged in mtDNA gene expression, yet these cellular populations did not consistently diverge in nDNA OXPHOS genes expression, nor did they correlate with the expression of glucagon, the hallmark of alpha cells. Thus, pancreatic beta cells within an individual are divided into distinct groups with unique metabolic-mitochondrial signature.