bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrimage entre le RSSS et les
municipalités dans le programme MADA : une analyse selon un modèle de la
gouvernance collaborative
Authors: Goudreault Nicolas , Garon Suzanne , Veil Anne , Lévesque Nancy 
Published: July 2021

Cadre de la recherche : Le
vieillissement de la population est particulièrement rapide au Québec et
s’accompagne d’une diminution du soutien aux personnes âgées (Maltais, 2018). De
surcroît, les aînés représentent un groupe social à haut risque d’isolement
social avec les conséquences importantes sur leur santé qui s’ensuivent
(Holt-Lunstad et al., 2017). Ces problématiques
requièrent la mise en place de programmes nationaux pour veiller au bien-être
des aînés, tel le programme Municipalités amies des aînés (MADA). Or, le
partenariat actuel entre les acteurs municipaux et ceux du RSSS est défaillant
et diminue son apport à la démarche.
Objectifs : Exposer les écueils qui
entravent le partenariat intersectoriel dans le programme MADA entre la
municipalité et le réseau de la santé et des services sociaux (RSSS), selon le
modèle de la gouvernance collaborative d’Ansell et Gash (2007). Dégager des
pistes de réflexion fondées sur des expériences réalisées au Québec. L’analyse
de celles-ci pourrait servir à améliorer le partenariat intersectoriel et,
ultimement, à mieux répondre aux besoins de la population vieillissante.
Méthodologie : Pour illustrer l’état
actuel du partenariat entre les acteurs municipaux et ceux du RSSS, nous avons
eu recours à une méthode qualitative suivant trois dispositifs : 1) une
recension sommaire des écrits; 2) les résultats de recherche de l’équipe de
recherche MADA-Québec; 3) des entrevues avec les acteurs du milieu (aux niveaux
stratégique, gestionnaire et opérationnel).
Résultats : Les entrevues ont permis de
faire ressortir les écueils présents dans le partenariat intersectoriel au
niveau des conditions préalables, selon le modèle de gouvernance collaborative
d’Ansell et Gash. Elles ont également aidé à identifier des expériences
réalisées au Québec qui peuvent servir de pistes de réflexion pour rétablir le
partenariat intersectoriel.
Conclusion : Le partenariat entre
acteurs municipaux et RSSS doit être optimisé afin d’assurer une réponse
adéquate aux besoins des aînés dans la démarche MADA.
Contribution : L’analyse selon le modèle
d’Ansell et Gash démontre une faiblesse du partenariat intersectoriel dans la
démarche MADA. Les expériences présentées pourront inspirer de nouvelles
pratiques prometteuses à cet égard.
Comparing audio- and video-delivered instructions in dispatcher-assisted cardiopulmonary resuscitation with drone-delivered automatic external defibrillator: a mixed methods simulation study
Authors: Kim Hyun-Jung , Kim Jin-Hwa , Park Dahye 
Published: July 2021

This study compared first responders’ cardiopulmonary resuscitation (CPR) performance when a dispatcher provides audio instructions only and when both audio and video instructions are given. In the simulation, an automatic external defibrillator (AED) was delivered via drone in response to a cardiac arrest occurring outside a hospital setting. Participants’ qualitative experiences were also explored.An exploratory sequential mixed methods design was used. AEDs were delivered to college students via drone with one group receiving both audio and video instructions and the other receiving audio-only instruction, and differences in CPR performance and accuracy were compared. After completion, focus group interview data were collected and analyzed. Video-based instruction was found to be more effective in the number of chest compressions (p < 0.01), chest compression rate (p < 0.01), and chest compression interruptions (p < 0.01). The accuracy of the video group for the chest compression region was high (p = 0.05). Participants’ experiences were divided into three categories: “unfamiliar but beneficial experience,” “met helper during a desperate and embarrassing situation,” and “diverse views on drone use.” Our results lay the groundwork for a development plan for providing emergency medical services using drones, as well as the preparation of guidelines for dispatchers on the provision of video instructions.
Associations of individual and joint expressions of ERCC6 and ERCC8 with clinicopathological parameters and prognosis of gastric cancer
Authors: Chen Jing , Li Liang , Sun Liping , Yuan Yuan , Jing Jingjing 
Published: July 2021

Background
Excision repair cross-complementing group 6 and 8 (ERCC6 and ERCC8) have been implicated in ailments such as genetic diseases and cancers. However, the relationship between individual and joint expressions of ERCC6/ERCC8 and clinicopathological parameters as well as prognosis of gastric cancer (GC) still remains unclear.

Methods
In this study, protein expressions of ERCC6, ERCC8 and ERCC6-ERCC8 were detected by immunohistochemistry (IHC) in 109 paired GC and para-cancerous normal tissue samples. The mRNA expression was detected in 36 pairs of tissue samples. IHC results and RNA-seq data extracted from The Cancer Genome Atlas (TCGA) were used to explore the clinical value of ERCC6 and ERCC8 expression in GC. We further conducted protein-protein interaction analysis, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, gene set enrichment analysis, and gene-gene interaction analysis to explore the function and regulation networks of ERCC6 and ERCC8 in GC.

Results
Individual and joint ERCC6/ERCC8 expression were significantly higher in adjacent normal mucosa compared with GC tissues. ERCC6 mRNA expression showed no difference in GC and paired tissues, while ERCC8 mRNA was significantly decreased in GC tissues. Protein expression of ERCC6, ERCC8, double negative ERCC6-ERCC8 and double positive ERCC6-ERCC8 and overexpressed ERCC6 mRNA were related to better clinicopathologic parameters, while overexpressed ERCC8 mRNA suggested worse parameters. Univariate survival analysis indicated that the OS was longer when ERCC6 protein expression and ERCC8 mRNA expression increased, and double negative ERCC6-ERCC8 expression was associated with a short OS. Bioinformatics analyses showed ERCC6 and ERCC8 were associated with nucleotide excision repair (NER) pathway, and six and ten gene sets were figured out to be related with ERCC6 and ERCC8, respectively. KEGG pathway showed that ERCC6/ERCC8 related gene sets were mainly involved in the regulation of PI3K/AKT/mTOR pathway. Direct physical interactions were found between ERCC6 and ERCC8.

Conclusions
Individual and joint expressions of ERCC6/ERCC8 were associated with clinical features of GC. Protein expression of ERCC6, ERCC6-ERCC8, and mRNA expression of ERCC8 were related to prognosis of GC. ERCC6 and ERCC8 primarily function in the NER pathway, and may regulate GC progression through the regulation of PI3K/AKT/mTOR pathway.
Comparative Study of Physiological and Haematological Parameters among Mild and Severe COVID-19 Patients Admitted in Tertiary Care Hospital of Pune District, India
Authors: Palve Suchita Sachin , Chaudhari Pallavi Sachin 
Published: July 2021

Background: The COVID-19 pandemic has put global health at stake by creating havoc all over the world, due to which the world, as well as health agencies, are experiencing the greatest challenges. This disease is a health emergency due to its high level of infectiousness and the non-availability of any specific treatment [1].
Objectives: To determine and compare the significance of physiological and haematological parameters in the diagnosis of COVID 19 infection and compare the association of physiological and haematological parameters among mild and severe COVID-19 patients.
Methodology: The present comparative, observational study was carried out in a designated tertiary care hospital, where admission of COVID19 patients in Pune district, India. Various parameters like age, height, weight, BMI, various physiological variables, haematological parameters, and CRP levels were assessed among 202 Mild and 50 severe COVID 19 diagnosed patients on day one of the hospital's stays.
Results: Pearson’s correlation coefficient showed a significant correlation among physiological and haematological variables compared to both groups, especially physiological parameters like SBP and DBP. The results showed that TLC, CRP, NLR, PLR, among COVID 19 patients cans work as important biomarkers to understand the disease prognosis.
Conclusion: Study of physiological and haematological parameters and their interrelation will help in understanding the impact of COVID 19 infection on the reactive inflammatory responses and help in understanding the prognosis of the disease among mild and severe patients.
Contribution of Ayurveda in the Management of Ksheena Shukra Vikara with Special Reference to Asthenozoospermia: A Case Report
Authors: Mohan Manju , Punam Sawarkar , Gaurav Sawarkar 
Published: July 2021

Background: Male Infertility is one of the burning issues now a day’s nevertheless disregarded reproductive health problems in India. Incidences of this issue expands day by day because of the disturbing lifestyle pattern. Almost 30-40-% of infertility cases found to be related to male factor. Asthenozoospermia is the most common identifiable anomaly related to male infertility found in semen analysis having reduced motility of sperm.
Aim and Objectives: To assess the efficacy of Ayurvedic management (Shodhana and Shamana Chikitsa) in the management of Ksheena Shukra Vikara w.s.r. to Asthenozoospermia.
Methods: It is a single case study. A 33-year-old male patient who was already diagnosed with Asthenozoospermia for three years approached to Pancharkarma OPD. Sperm motility was only 12%. The patient was treated with Shodhana Chikitsa (Vamana and Virechana with Mahatiktaka Ghritapana and Dashmooladi Niruha Vasti and Uttarvasti with Vidaryadi Ghrita followed by Shamana Chikitsa (Tab Neo Charak Pharmacy, Tab Addyzoa, Chandraprabha Vati, Paripathadi Kashaya, Ashwagandhadi Yamaka, Avipattikar Churna) approximately 3 months. After 3 months, patient-reported improvement.
Results: Assessment of the patient with clinical symptoms and sperm analysis report was done following 3 months. Sperm motility increased up to 40% with increment in sperm count.
Conclusion: This case report provides us a guideline that infertility associated with Asthenozoospermia can be treated successfully by adopting basic Ayurveda Siddhanta's.
A Bionanozyme with Ultrahigh Activity Enables Spatiotemporally Controlled Reactive Oxygen Species Generation for Cancer Therapy
Authors: Xu Zhen , Zhang Li , Pan Min , Jiang Qunying , Huang Yunjie , Wang Fuan , Liu Xiaoqing 
Published: July 2021

AbstractNanozymes hold great potential in nanomedicine, yet biotoxicity limits their clinical translation because of their uncontrolled catalytic activity, artificial inorganic components, and harsh synthesis conditions. Herein, a peroxidase‐like bionanozyme with ultrahigh and photocontrolled catalytic activity through the self‐assembly of biomolecules, hemin, and in situ polymerization of pyrrole in an aqueous solution is reported. Such bionanozymes leverage the specific cues of the tumor microenvironment and precise light‐induced photothermal heating for spatiotemporally controlled reactive oxygen species generation in tumors. The tunable catalytic activity and excellent biocompatibility of the bionanozyme result in high cancer cell apoptosis and tumor growth inhibition in murine models with negligible biotoxicity. This work highlights the potential of biomolecule‐based nanozymes for cancer‐specific therapy. Bionanozymes with ultrahigh and tunable catalytic activity may lay the important foundation for more advanced nanomedicine and biosensing.
An Injectable Multifunctional Dual‐Phase Bead‐Reinforced Gelatin Matrix Permissive of Mesenchymal Stem Cell Infiltration for Musculoskeletal Soft Tissue Repair
Authors: Du Dajiang , Liu Zhen , Niu Wanting , Weng Ding , Lim Teck Chuan , Kurisawa Motoichi , Spector Myron 
Published: July 2021

AbstractThis study develops a novel strategy for regenerative therapy of musculoskeletal soft tissue defects using a dual‐phase multifunctional injectable gelatin‐hydroxyphenyl propionic acid (Gtn‐HPA) composite. The dual‐phase gel consists of stiff, degradation‐resistant, ≈2‐mm diameter spherical beads made from 8 wt% Gtn‐HPA in a 2 wt% Gtn‐HPA matrix. The results of a 3D migration assay show that both the cell number and migration distance in the dual‐phase gel system are comparable with the 2 wt% mono‐phase Gtn‐HPA, but notably significantly higher than for 8 wt% mono‐phase Gtn‐HPA (into which few cells migrated). The results also show that the dual phase gel system has degradation resistance and a prolonged growth factor release profile comparable with 8 wt% mono‐phase Gtn‐HPA. In addition, the compressive modulus of the 2 wt% dual‐phase gel system incorporating the 8 wt% bead phase is nearly four‐fold higher than the 2 wt% mono‐phase gel (5.3 ± 0.4 kPa versus 1.5 ± 0.06 kPa). This novel injectable dual‐phase Gtn‐HPA composite thus combines the advantages of low‐concentration Gtn‐HPA (cell migration) with high‐concentration Gtn‐HPA (stiffness, degradation resistance, slower chemical release kinetics) to facilitate effective reparative/regenerative processes in musculoskeletal soft tissue.
Control of Water Adsorption via Electrically Doped Graphene: Effect of Fermi Level on Uptake and H2O Orientation
Authors: Bagheri Morteza H. , Loibl Rebecca T. , Schiffres Scott N. 
Published: July 2021

AbstractThe interaction of graphene with water molecules under an applied electric field is not thoroughly understood, yet this interaction is important to many thermal, fluidic, and electrical applications of graphene. In this work, the effect of electrical doping of graphene on water adsorption is studied through adsorption isotherms and current–voltage (IV) characterizations as a function of the Fermi level. The water adsorption onto graphene increases by ≈15% and the doping levels increase by a factor of three with a gate‐to‐graphene voltage of +20 or −20 V compared to 0 V for sub‐monolayer adsorption. This change in uptake is attributed to the increase in density of state of graphene upon electrical‐doping, which changes the Coulombic and van der Waals interactions. The water adsorption onto graphene is either n‐ or p‐doping depending on the applied gate‐to‐graphene voltage. The ambi‐doping nature of water onto graphene is due to the polar nature of water molecules, so the doping depends on the orientation of the water molecules.
Nanotextured Surfaces Lead to Differential Wettability of Compound Droplets
Authors: Berli Claudio L. A. , Bellino Martín G. 
Published: July 2021

AbstractWater interaction with nanotextured surfaces is critical in diverse natural and technological processes. In general, water is not perfectly pure and can often contain low amounts of oily components. Here it is revealed how, contrary to wetting behavior on non‐porous surfaces, a tiny amount of oil can critically influence water wettability on nanopore structures. Surfaces coated with nanoporous thin films are used to show that water droplets undergo a nanopore‐triggered instantaneous meaningful spreading effect when adding parts‐per‐million (ppm) amounts of oil. Remarkably, minute oil fractions affect water wettability on the nanosurface more than large oil fractions. Moreover, the binary droplets exhibit contact angles even smaller than those of pure components. The physical reason behind the peculiar wetting response of nanopore surfaces arising from traces of oil in water can be attributed to spontaneous transport phenomena in the pore network. The ppm level oil‐in‐water composed droplets also show enhanced mobility on the nanoporous surfaces, as evidenced by very small sliding angles. This feature is indeed leveraged to demonstrate a self‐slippery droplet‐surface system. The study unveils that the presence of ultra‐low concentrations of oil can cause distinctive water‐nanosurface interplays, providing a fresh framework in both water‐related nature phenomena and technical applications.
Ultrasensitive WSe2/α‐In2Se3 NIR Photodetector Based on Ferroelectric Gating Effect
Authors: Jin Hyeok Jun , Park Cheolmin , Lee Khang June , Shin Gwang Hyuk , Choi Sung‐Yool 
Published: July 2021

AbstractThe suppression of dark current is crucial for enhancing the sensitivity of photodetectors, particularly for infrared photodetection. In this study, to overcome the low sensitivity of photodetectors in the infrared wavelength range, a photodetector comprising a 2D semiconductor (WSe2) heterojunction and 2D ferroelectric semiconductor (α‐In2Se3) is developed. WSe2 is fully depleted owing to the ferroelectric gating effect of α‐In2Se3; this enhanced the photodetector detectivity. In addition, photoresponsivity is increased because the n‐type α‐In2Se3 formed a PN junction with the p‐type WSe2. Owing to the ferroelectric gating effect of α‐In2Se3, the dark current in the photodetector is suppressed above 103 times, the photoresponsivity is increased 13.8 times from 0.16 to 2.21 A W−1, and the specific detectivity is increased 437 times from 2.18 × 108 Jones to 9.52 × 1010 Jones at a near‐infrared (NIR) wavelength of 980 nm. The proposed WSe2/α‐In2Se3 heterostructure with an ultrasensitive characteristic in the NIR wavelength range, can contribute significantly to practical photodetector applications.
Manganese(III) Acetate Catalyzed Aerobic Dehydrogenation of Tertiary Indolines, Tetrahydroquinolines and an N‐Unsubstituted Indoline
Authors: Niu Xiaokang , Yang Lei 
Published: July 2021

AbstractA Mn(OAc)3 ⋅ 2H2O‐catalyzed aerobic dehydrogenation of five and six‐membered N‐heterocycles for the synthesis of N‐heteroarenes is reported. Of note, this protocol can be applied to the dehydrogenation of tertiary indolines with various electron‐deficient N‐substituents. Preliminary mechanistic investigations support that a single‐electron transfer pathway might be involved.magnified image
Analysis of Product Sustainability by Using a Risk‐Oriented System Dynamics Model
Authors: Sezer Muruvvet Deniz , Selim Hasan 
Published: July 2021

AbstractMeasuring product sustainability plays a significant role to gain competitive advantage. Nevertheless, while achieving sustainable products, all related risks associated with sustainability should be considered. Previous studies are limited by the lack of the dynamic and multidimensional approaches. However, as the decision‐making environment is constantly changing in the real world, a dynamic decision‐making approach is required. The aim of this study is to develop a dynamic and risk‐driven approach to investigate the product sustainability risks. The proposed approach considers all the related risks and interactions with a holistic view covering environmental, economic, and social sustainability. To deal with the dynamic and multidimensional nature of product sustainability, system dynamics is proposed. The results show that increasing the production capacity of the company and maintaining the production emphasizing innovation have led to improvements on both product sustainability and the main dimensions of sustainability. The realization of Industry I4.0 applications can be an effective strategy for the business to increase product sustainability. This study is supported with a case study implemented in the manufacturing industry to confirm the applicability of the model. This paper is useful for industry and policy makers to observe the potentials impacts of products sustainability risks.
Effect of the TiO2 Nanocrystal Dispersion Over SBA‐15 in the Photocatalytic H2 Production Using Ethanol as Electron Donor
Authors: Torres‐Garcia Nidia L. , Fresno Fernando , Oropeza Freddy E. , Huirache‐Acuña Rafael , de la Peña‐O'Shea Víctor A. 
Published: July 2021

AbstractIn this work, a series of TiO2‐based photocatalysts supported on mesoporous silica SBA‐15, which are synthesized with different wt% (10, 20, 40, 60, and 80) of TiO2, are studied. The catalysts are evaluated in gas‐phase H2 photo‐production using ethanol as an electron donor, observing changes in the hydrogen evolution with the TiO2 loading with an optimum charge of 20% w/w. In addition, the presence of Pt leads to a huge enhancement of the catalytic activity showing also a volcano plot behavior, the 20% w/w again being the best catalyst (895.9 µmol H2 gcat−1). This system also exhibits a high stability without a decrease in the production after 15 h. By means of different characterization techniques, it is possible to determine the interaction among the active phase, the metallic nanoparticle, and the catalytic support. These studies indicate that the use of mesoporous silica SBA‐15 as a support increases the dispersion of the active phase, resulting in an increase in the evolution rate of H2. However, the lowest percentages of TiO2 give rise to amorphous TiO2 particles with high amount of superficial defects increasing the e−‐h+ recombination rate and decreasing the H2 production.
The impact of pancreas compression time during minimally invasive gastrectomy on the postoperative complications in gastric cancer
Authors: Itamoto Kota , Hikage Makoto , Fujiya Keiichi , Kamiya Satoshi , Tanizawa Yutaka , Bando Etsuro , Terashima Masanori 
Published: July 2021

AbstractAimPancreas compression during minimally invasive gastrectomy causes blunt injury to the pancreas and leads to postoperative complications. However, the extent of practical compression associated with the incidence of postoperative complications remains unknown. This study aimed to evaluate the impact of pancreas compression, particularly the duration of compression, on short‐term outcomes in minimally invasive gastrectomy for gastric cancer.MethodsThis study included 178 patients who underwent laparoscopic or robotic gastrectomy at the Shizuoka Cancer Center in 2018. The total time of pancreas compression during gastrectomy was measured using video‐reviews, and the correlation between the time and surgical outcomes was evaluated.ResultsA duration of 3 min was selected as the cutoff value of pancreas compression time to predict high drain amylase concentration on postoperative day 1 (≥1000 U/L). The incidence of clinically relevant pancreatic fistula (1.5% vs 12.4%, P = .011) and all postoperative complications (12.3% vs 30.1%, P = .010) were significantly higher in the longer‐compression group than in the shorter‐compression group. The multivariable analysis identified longer compression as the only independent risk factor for postoperative complications.ConclusionMore than a few minutes of pancreas compression during minimally invasive gastrectomy was associated with a higher incidence of postoperative complications.
Stretchable gas barrier films achieved by hydrogen‐bond self‐assembly of nano‐brick multilayers
Authors: Shi Kaiqiang , Xu Xiaozhi , Dong Siyuan , Li Biao , Han Jingbin 
Published: July 2021

AbstractInorganic–organic hybrid films containing two‐dimensional nanosheets have shown good gas barrier performance, but moderate tensile property, because of the rigid characteristics of covalent or ionic bonds between the assembly units. In this work, we used LDH nanosheets rich in hydroxyl groups as building units, followed by modification of tannic acid (TA), to assemble with polyethylene oxide (PEO) through hydrogen bonds. Compared with previous work, the tensile property and oxygen barrier performance of (TA@LDH/PEO)n films have been significantly improved. A 50‐bilayer TA@LDH/PEO film, deposited on a 1 mm thick natural rubber substrate, results in a 29× reduction (contrast with bare substrate) in oxygen transmission rate and maintains its good barrier property even under a large elongation of 120%. The excellent tensile and gas barrier properties are attributed to the ductility of hydrogen bond network among building blocks and the significant prolongation of oxygen transmission path induced by LDH nanosheets.