bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen defects in feldspars: defect properties and implications for water solubility in feldspar
Authors: Behrens Harald 
Published: January 2021

AbstractHydrogen defects can strongly affect mechanical and chemical properties of feldspars. To get insight into the behavior of such defects, alkali feldspar and plagioclase of igneous origin were studied combining IR spectroscopy with heating experiments under well-controlled conditions. Near-infrared spectra show that OH groups are the predominant hydrous species in these feldspars but presence of minor amounts of molecular H2O cannot be excluded. Short-term annealing at 400–800 °C produces a small but significant irreversible change in the OH stretching vibration band which is attributed to relaxation of the feldspar structure. Polarized mid-infrared spectra of sanidine, adularia, and plagioclase recorded in situ at temperatures up to 600 °C show reversible shifts of maxima toward higher wavenumber and an overall decrease in integrated intensities. The pleochroic features of the OH vibration bands, i.e., the predominant orientation of OH dipoles along the crystallographic a axis in all feldspars and the additional band component perpendicular to the (010) plane in sanidine are still present in the high-temperature spectra. Different behavior during long-term annealing at high temperature was found for the alkali feldspars and the plagioclases. At 900–1000 °C, the Eifel sanidines rapidly lost about one quarter of the initial water content which is attributed to a weakly bound hydrogen species in the feldspar structure. The remaining hydrogen is very strongly bound and was still detectable in 0.7–0.9 mm thick sections after annealing for 108 days at 1000 °C in air dried by phosphorus pentoxide. In contrast, a 1-mm-thick section of plagioclase completely lost hydrogen during heating in air within 8 days at 1000 °C. After partial dehydration, the pleochroic behavior of the OH absorption bands of the feldspars was basically preserved except that the 3050 cm−1 band of the sanidine, oriented perpendicular to (010), becomes more pronounced than the 3400 cm−1 band, oriented parallel to the a direction. Annealing experiments at 1000 °C under controlled water pressures indicate equilibrium solubilities of several tens of ppm H2O in the plagioclases and more than 100 ppm H2O in the alkali feldspars already at 1 bar water pressure. The variation of the water content with H2O pressure and spectroscopic observations indicates that the water content in the feldspars is determined not only by the water pressure but also by already existing defects. Vacancies on alkali sites (VA1) may accommodate H2O molecules, possibly with subsequent hydrolysis of network bonds to minimize local stress. A likely explanation for the strongly bound hydrogen in the sanidine is a coupled substitution of H+  + Al3+ for Si4+ (AlOH defect) where the protons are located on interstitial sites. This incorporation model is supported by the complete recovery of the defects in H2O vapor after previous proton/alkali exchange in alkali chloride vapor at 1000 °C.
Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)
Authors: Yilmaz A. , Bauersachs J. , Bengel F. , Büchel R. , Kindermann I. , Klingel K. , Knebel F. , Meder B. , Morbach C. , Nagel E. , Schulze-Bahr E. , aus dem Siepen F. , Frey N. 
Published: January 2021

AbstractSystemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition to diagnosing cardiac amyloidosis. Endomyocardial biopsy still plays a major role in the histopathological diagnosis and subtyping of cardiac amyloidosis. The main objective of the diagnostic algorithm outlined in this position statement is to detect cardiac amyloidosis as reliably and early as possible, to accurately determine its extent, and to reliably identify the underlying subtype of amyloidosis, thereby enabling subsequent targeted treatment.
Characterization of novel pollen-expressed transcripts reveals their potential roles in pollen heat stress response in Arabidopsis thaliana
Authors: Rutley Nicholas , Poidevin Laetitia , Doniger Tirza , Tillett Richard L. , Rath Abhishek , Forment Javier , Luria Gilad , Schlauch Karen A. , Ferrando Alejandro , Harper Jeffery F. , Miller Gad 
Published: January 2021

Abstract
Key message
Arabidopsis pollen transcriptome analysis revealed new intergenic transcripts of unknown function, many of which are long non-coding RNAs, that may function in pollen-specific processes, including the heat stress response.

Abstract
The male gametophyte is the most heat sensitive of all plant tissues. In recent years, long noncoding RNAs (lncRNAs) have emerged as important components of cellular regulatory networks involved in most biological processes, including response to stress. While examining RNAseq datasets of developing and germinating Arabidopsis thaliana pollen exposed to heat stress (HS), we identified 66 novel and 246 recently annotated intergenic expressed loci (XLOCs) of unknown function, with the majority encoding lncRNAs. Comparison with HS in cauline leaves and other RNAseq experiments indicated that 74% of the 312 XLOCs are pollen-specific, and at least 42% are HS-responsive. Phylogenetic analysis revealed that 96% of the genes evolved recently in Brassicaceae. We found that 50 genes are putative targets of microRNAs and that 30% of the XLOCs contain small open reading frames (ORFs) with homology to protein sequences. Finally, RNAseq of ribosome-protected RNA fragments together with predictions of periodic footprint of the ribosome P-sites indicated that 23 of these ORFs are likely to be translated. Our findings indicate that many of the 312 unknown genes might be functional and play a significant role in pollen biology, including the HS response.
Facing the digital divide into a dementia clinic during COVID-19 pandemic: caregiver age matters
Authors: Arighi Andrea , Fumagalli Giorgio Giulio , Carandini Tiziana , Pietroboni Anna Margherita , De Riz Milena Alessandra , Galimberti Daniela , Scarpini Elio 
Published: January 2021

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) pandemic has dramatically stressed the health care system and has provoked changes in population use of digital technologies. Digital divide is any uneven distribution in Information and Communications Technologies between people.AimsThe purpose of this work was to describe the digital divide of a population of patients with dementia contacted by telemedicine during Italian lockdown for COVID-19 pandemic.MethodOne hundred eight patients with cognitive impairment were contacted by video call to perform a telemedicine neurological evaluation. Information on patients and caregivers attending the televisit were recorded.ResultsSeventy-four patients connected with neurologist (successful televisit, 68.5%) and 34 patients were not able to perform televisit and were contacted by phone (failed televisit, 31.5%). No significant differences were observed among the two groups concerning age, gender, and education, but the prevalence of successful televisit was higher in the presence of younger caregivers: televisits performed in the presence of subjects of younger generation (sons and grandsons) had a successful rate higher (86% successful, 14% failed) than the group without younger generation caregiver (49% successful, 51% failed). This difference is mainly due to the ability of technological use among younger people.DiscussionThe most impacting factors on digital divide in our population are the social support networks and the experience with the technology: the presence of a digital native caregiver. The COVID-19 pandemic is unmasking an emerging form of technology-related social inequalities: political and community interventions are needed to support the most socially vulnerable population and prevent social health inequalities.
Healthcare resource utilization and associated cost of patients with bone metastases from solid tumors who are naïve to bone-targeting agents: a comparative analysis of patients with and without skeletal-related events
Authors: Hardtstock Fränce , Kocaata Zeki , Wilke Thomas , Dittmar Axel , Ghiani Marco , Belozeroff Vasily , Harrison David J. , Maywald Ulf , Tesch Hans 
Published: January 2021

Abstract
Background
This study analyzes the impact of skeletal-related events (SRE) on healthcare resource utilization (HCRU) and costs incurred by patients with bone metastases (BM) from solid tumors (ST), who are therapy-naïve to bone targeting agents (BTAs).

Methods
German claims data from 01/01/2010 to 30/06/2018 were used to conduct a retrospective comparative cohort analysis of BTA-naive patients with a BM diagnosis and preceding ST diagnosis. HCRU and treatment-related costs were compared in two matched cohorts of patients with and without a history of SREs, defined as pathological fracture, spinal cord compression, surgery to bone and radiation to bone. The first SRE was defined as the patient-individual index date. Conversely, for the non-SRE patients, index dates were assigned randomly.

Results
In total, 45.20% of 9,832 patients reported experiencing at least one SRE (n = 4444) while 54.80% experienced none (n = 5388); 2,434 pairs of SRE and non-SRE patients were finally matched (mean age: 70.87/71.07 years; females: 39.07%/38.58%). Between SRE and non-SRE cohorts, significant differences in the average number of hospitalization days per patient-year (35.80/30.80) and associated inpatient-care costs (14,199.27€/10,787.31€) were observed. The total cost ratio was 1.16 (p < 0.001) with an average cost breakdown of 23,689.54€ and 20,403.27€ per patient-year in SRE and non-SRE patients.

Conclusion
The underutilization of BTAs within a clinical setting poses an ongoing challenge in the real-world treatment of BM patients throughout Germany. Ultimately, the economic burden of treating SREs in patients with BM from ST was found to be considerable, resulting in higher direct healthcare costs and increased utilization of inpatient care facilities.
Geriatric syndromes and subsequent health-care utilization among older community dwellers in Stockholm
Authors: Möller Jette , Rausch Christian , Laflamme Lucie , Liang Yajun 
Published: January 2021

AbstractLittle is known about the long-term effect of geriatric syndromes on health-care utilization. This study aims to determine the association between geriatric syndromes and health-care utilization during a four-year period among older community dwellers. Based on the Stockholm Public Health Cohort study, a total number of 6700 community dwellers aged ≥65 years were included. From a baseline survey in 2006, geriatric syndromes were defined as having at least one of the following: insomnia, functional decline, urinary incontinence, depressive symptoms and vision impairment. Health-care utilization was identified by linkages at individual level with register data with a four-year follow-up. Cox regression was performed to estimate the associations. Compared to those without geriatric syndromes, participants with any geriatric syndromes had a higher prevalence of frequent hospitalizations, long hospital stays, frequent outpatient visits and polypharmacy in each of the follow-up years. After controlling for covariates, having any geriatric syndromes was associated with higher levels of utilization of inpatient and outpatient care as well as polypharmacy. The association was stable over time, and the fully adjusted hazard ratio (95% confidence interval) remained stable in frequent hospitalizations (from 1.89 [1.31, 2.73] in year 1 to 1.70 [1.23, 2.35] in year 4), long hospital stay (from 1.75 [1.41, 2.16] to 1.49 [1.24, 1.78]), frequent outpatient visits (from 1.40 [1.26, 1.54] to 1.33 [1.22, 1.46]) and polypharmacy (from 1.63 [1.46, 1.83] to 1.53 [1.37, 1.71]). Having any geriatric syndromes is associated with higher levels of health-care utilization among older community dwellers, and the impact of geriatric syndromes is stable over a four-year period.
Balancing trust and control through dialogue meetings in Norwegian school district governance
Authors: Henriksen Øyvind H. , Paulsen Jan Merok 
Published: January 2021

AbstractIncreased attention has been paid to school superintendents and their role in school reforms. Still, there are few studies on dialogue meetings between actors at different levels in the school hierarchy. The current paper investigates how a superintendent balances between trust and control while supporting school development through dialogue meetings. Drawing on interviews, reflection notes, and longitudinal observational data from dialogue meetings, comprising a superintendent, subordinated school leaders, and team leaders, this action research study provides insight into requirements for productive dialogue meetings. We argue that superintendent leadership through regular dialogue meetings can foster trust-building, empowerment, and professional commitment.
Identification of thermal material parameters for thermo-mechanically coupled material models
Authors: Rose L. , Menzel A. 
Published: January 2021

AbstractThe possibility of accurately identifying thermal material parameters on the basis of a simple tension test is presented, using a parameter identification framework for thermo-mechanically coupled material models on the basis of full field displacement and temperature field measurements. Main objective is to show the impact of the material model formulation on the results of such an identification with respect to accuracy and uniqueness of the result. To do so, and as a proof of concept, the data of two different experiments is used. One experiment including cooling of the specimen, due to ambient temperature, and one without specimen cooling. The main constitutive relations of two basic material models are summarised (associated and non-associated plasticity), whereas both models are extended so as to introduce an additional material parameter for the thermodynamically consistent scaling of dissipated energy. The chosen models are subjected to two parameter identifications each, using the data of either experiment and focusing on the determination of thermal material parameters. The influence of the predicted dissipated energy of the models on the identification process is investigated showing that a specific material model formulation must be chosen carefully. The material model with associated evolution equations used within this work does neither allow a unique identification result, nor is any of the solutions for the underlying material parameters close to literature values. In contrast to that, a stable, that is locally unique, re-identification of the literature values is possible for the boundary problem at hand if the model with non-associated evolution equation is used and if cooling is included in the experimental data.
Drought resistance and gum yield performances in a Senegalia senegal (L.) Britton progeny trial in Senegal
Authors: Sarr Mame S. , Seiler John R. , Sullivan Jay , Diallo Adja M. , Strahm Brian D. 
Published: January 2021

AbstractWith continued global change as a result of land use changes, invasive species and changing climatic patterns, it is becoming increasingly important to understand the adaptability of Senegalia senegal provenances to maximize resilience in managed and natural populations of this species. The objective of this study is to investigate Senegalia senegal genotypic differences in water use efficiency (WUE) measured by stable 13C isotope composition in foliage according to their ploidy levels. Secondary objectives are to discuss inherent adaptive variation related to soil pH, survival, growth indexes, gum arabic yield and WUE within provenance in the climate change context. A Senegalia senegal progeny trial, in Dahra, Senegal was used in this study: 443 adult trees consisting of 60 families nested within 4 provenances were assessed in this study. Results showed significant differences in gum yield among provenances (P = 0.0002) and families (P < 0.0001). Diamenar and Ngane provenances showed overall similar annual gum yield despite a lower tree survival rate of Ngane than Diamenar. Growth traits, especially stem volume index and crown area index were larger on Ngane provenance, which also displayed significantly higher foliar WUE and lower leaf area index (LAI) than the other provenances. WUE was positively correlated with gum yield (P = 0.0302), but the coefficient of determination was only 2%. Foliar δ13C varied significantly (P < 0.0001) between diploids (− 27.91‰) and polyploids (− 27.12‰). However, within each provenance no significant difference was found. Only 15% of isotope compositions could be explained by ploidy level variation. Differences found in growth and gum yield may be attributed to genotype-specific variation. However, a significant correlation between soil pH and tree survival rate was found (P = 0.0051; r = 0.60). This study confirmed a possible improvement of the gum arabic sector through genotype based selection. Ngane and Diamenar seem to be more profitable to grow in Dahra than the other tested provenances. Future research should investigate the effect of soil pH, other soil physical and chemical properties, and management activities to improve site quality on tree survival and gum yields among provenances. Further, more research is needed to clarify inherent traits underlying drought tolerance in the field and gum yield performance.
Global Analysis of Gene Expression Profiles in Glutinous Rice 89-1 (Oryza sativa L.) Seedlings Exposed to Chilling Stress
Authors: Pan Xiaoxue , Wu Hong , Hu Mingyu , Wang Zhongwei , Jiang Xiaoying , Guan Ling , Bai Wenqin , Lei Kairong 
Published: January 2021

AbstractRice (Oryza sativa) is a tropical cereal crop that is severely affected by chilling stress at the seedling stage, although glutinous rice 89-1 (Gr89-1) in Chongqing, China, shows tolerance to low temperatures and overwintering ability. However, little research has been conducted on the mechanisms regulating chilling stress in Gr89-1. In this study, a comprehensive of transcriptional profiles of Gr89-1 seedlings at the three-leaf stage was conducted after a 4 °C treatment for 2, 6, 12, 24, or 48 h. Overall, 2993 differentially expressed genes were detected in Gr89-1 seedlings upon cold exposure. Gene Ontology testing and pathway analysis revealed differentially expressed genes involved in transcriptional regulation, carbohydrate metabolism, plant hormone signal, and cell wall composition. A total of 243 transcription factors were differentially expressed during the cold treatment; in particular, the AP2/EREBP, bHLH, NAC, WRKY, C2H2, and TIFY families were generally upregulated after cold treatment, whereas the mTERF and GNAT families were downregulated. Chilling stress changed the starch and sucrose metabolism, coupled with the accumulation of sucrose and trehalose level, and increases in jasmonic acid level in Gr89-1 seedlings. Furthermore, a number of the cell wall-related genes identified in the present study were also differentially expressed during the cold treatment. The genes and pathways identified in the current study increase our understanding of the mechanisms underlying cold resistance in rice seedlings.
A comparison between two different dried blood substrates in determination of psychoactive substances in postmortem samples
Authors: Moretti Matteo , Manfredi Alessandro , Freni Francesca , Previderé Carlo , Osculati Antonio Marco Maria , Grignani Pierangela , Tronconi Livio , Carelli Claudia , Vignali Claudia , Morini Luca 
Published: January 2021

AbstractPurposeWhatman™ 903 cards represent a valid type of support for collection, storage, and analysis of dried blood spots (DBS). Whatman™ FTA (Flinders Technology Associates) are a type of cards soaked in chemicals that cause denaturation of proteins, while preserving DNA and ensuring the safe handling of DBS; to date, these cards are still rarely employed in forensic toxicology. The aim of this study was to analyze several psychoactive substances on not-dried blood on the two different cards and to compare the qualitative and quantitative results.MethodsTwenty cardiac postmortem blood samples were collected and deposed on Whatman™ 903 and Whatman™ FTA cards. Spots and not-dried blood were analyzed following our validated and previously published liquid chromatography–mass spectrometry methods.ResultsWe were able to identify: eight drugs of abuse and their metabolites (15 cases), five benzodiazepines and their metabolites (3 cases), six antidepressants (6 cases) and two antipsychotics (3 cases). We observed a perfect qualitative correspondence and a general good quantitative correlation between data obtained from not-dried blood and the two different DBS cards, except for alprazolam, diazepam, desmethyldiazepam, fluoxetine and sertraline, that showed a lower concentration on FTA. Additional experiments suggest that the chemicals, adsorbed on FTA, are not the cause of the loss of signal observed for the substances previously mentioned and that methanol should be preferred as extraction solvent.ConclusionsThis study proved that FTA cards are a good and a hazard-free alternative sample storage method for analysis of several psychoactive substances in postmortem blood.
Improving access to geodetic imaging crustal deformation data using GeoGateway
Authors: Donnellan Andrea , Parker Jay , Heflin Michael , Glasscoe Margaret , Lyzenga Gregory , Pierce Marlon , Wang Jun , Rundle John , Ludwig Lisa Grant , Granat Robert , Mirkhanian Megan , Pulver Nathan 
Published: January 2021

AbstractGeoGateway (http://geo-gateway.org) is a web-based interface for analysis and modeling of geodetic imaging data and to support response to related disasters. Geodetic imaging data product currently supported by GeoGateway include Global Navigation Satellite System (GNSS) daily position time series and derived velocities and displacements and airborne Interferometric Synthetic Aperture Radar (InSAR) from NASA’s UAVSAR platform. GeoGateway allows users to layer data products in a web map interface and extract information from various tools. Extracted products can be downloaded for further analysis. GeoGateway includes overlays of California fault traces, seismicity from user selected search parameters, and user supplied map files. GeoGateway also provides earthquake nowcasts and hazard maps as well as products created for related response to natural disasters. A user guide is present in the GeoGateway interface. The GeoGateway development team is also growing the user base through workshops, webinars, and video tutorials. GeoGateway is used in the classroom and for research by experts and non-experts including by students.