bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of left ventricular function improvement for cardiac resynchronization therapy candidates
Authors: Hong Jung Ae , Lee Sang Eun , Kim Seon‐Ok , Kim Min‐Seok , Lee Hae‐Young , Cho Hyun‐Jai , Choi Jin Oh. , Jeon Eun‐Seok , Hwang Kyung‐Kuk , Chae Shung Chull , Baek Sang Hong , Kang Seok‐Min , Choi Dong‐Ju , Yoo Byung‐Su , Kim Kye Hun , Cho Myeong‐Chan , Oh Byung‐Hee , Kim Jae‐Joong 
Published: December 2021

AbstractAimsA waiting period of more than 3 months is recommended for patients before undergoing cardiac resynchronization therapy (CRT). However, due to an anticipated high mortality rate, early implementation of CRT might be beneficial for some patients. We aimed to evaluate the rate and the probability of left ventricular (LV) function improvement and their predictors in patients with heart failure (HF) with indications for CRT.Methods and resultsFrom March 2011 to February 2014, a total of 5625 hospitalized patients for acute HF were consecutively enrolled in 10 tertiary hospitals. Among them, we analysed 1792 patients (mean age 63.96 ± 15.42 years, female 63.1%) with left ventricular ejection fraction (LVEF) ≤ 35% at the baseline echocardiography and divided them into three groups: 144 with left bundle branch block (LBBB), 136 with wide QRS complexes without LBBB, and 1512 not having these findings (control). We compared and analysed these three groups for improvement of LV function at follow‐up echocardiography. In patients who met CRT indications (patients with LBBB or wide QRS complexes without LBBB), logistic regression was performed to identify risk factors for no improvement of LV. No improvement of LV was defined as LVEF ≤ 35% at follow‐up echocardiography or the composite adverse outcomes: death, heart transplantation, extracorporeal membrane oxygenation, or use of a ventricular assist device before follow‐up echocardiography. A classification tree was established using the binary recursive partitioning method to predict the outcome of patients who met CRT indications. In a median follow‐up of 11 months, LVEF improvement was observed in 24.3%, 15.4%, and 40.5% of patients with LBBB, wide QRS complexes without LBBB, and control, respectively. Patients meeting CRT indications had higher 3 month mortality rates than the control (24.6% vs. 17.7%, P = 0.002). Multivariable logistic regression analysis revealed that large LV end‐systolic dimension [odds ratio (OR) 1.10, 95% confidence interval (CI) 1.05–1.15, P < 0.001], low LVEF (OR 0.92, 95% CI 0.87–0.98, P = 0.006), diabetes requiring insulin (OR 6.49, 95% CI 2.53–19.33, P < 0.001), and suboptimal medical therapy (OR 6.85, 95% CI 3.21–15.87, P < 0.001) were significant factors predictive of no improvement. A decision tree analysis was consistent with these results.ConclusionsPatients with CRT indications had higher mortality during their follow‐up compared with control. LV function improvement was rare in this population, especially when they had some risk factors. These results suggest that the uniform waiting period before CRT implantation could be reconsidered and individualized.
Lanthanide Complexes with 4,4′‐Bis(2‐sulfonatostyryl)‐biphenyl: Crystal Structures and Luminescence Properties
Authors: Mikhalyova Elena A. , Zeller Matthias , Goreshnik Evgeny A. , Jasinski Jerry P. , Butcher Raymond J. , Nelyubina Yulia V. , Hunter Jordan L. , Sedykh Alexander E. , Shishkina Svitlana V. , Müller‐Buschbaum Klaus , Eremenko Igor L. , Addison Anthony W. , Pavlishchuk Vitaly V. 
Published: December 2021

AbstractA series of new tris(pyrazolyl)borate (Tp−) and tris(2‐pyridylpyrazolyl)borate (TpPy−) Eu3+, Gd3+, Tb3+ and Dy3+ complexes with the dianionic ligand 4,4′‐bis(2‐sulfonatostyryl)biphenyl (Ssp2−, a widely used fluorescent whitener) were synthesized and their luminescence properties were studied. The Gd3+, Tb3+ and Dy3+ compounds possess only ligand‐centered emission, arising from the Ssp2− ligand, with quantum yields of up to 60 %. While the emission centers in these complexes are similar, the positions of the luminescence maxima, the emission quantum yields, and the lifetimes change in the order [(Tp2Ln)2Ssp]<[(TpPyLnSsp)2]<[Ln2Ssp3]n. Among the complexes studied, Eu3+‐centered emission was observed for only [(Tp2Eu)2Ssp]. In this compound, Tp− plays the role of an antenna ligand for Eu3+‐radiation, though the quantum yield is only 5 %.
Gold‐Catalyzed Cascade and Divergent Synthesis of Indolobenzazepines and Indoloquinolines from Nitrogen‐Tethered 1,8‐Diynes
Authors: Ito Mamoru , Onoda Hideaki , Takaki Asahi , Shibata Takanori 
Published: December 2021

AbstractWe describe the divergent construction of two nitrogen‐containing polycyclic systems by gold‐catalyzed cycloisomerizations. The gold‐catalyzed cascade hydroamination and 7‐endo‐dig‐selective cycloisomerization of nitrogen‐tethered 1,8‐diynes yielded indolo[1,7‐ab]benzazepines in one pot. In contrast, when Johnphos‐coordinated gold catalyst was used, the same 1,8‐diynes were transformed into indolo[1,2‐a]quinolines by 6‐endo‐dig‐selective cycloisomerization along with rearrangement of the substituent on one of the alkynes. The reaction of a naphthalene‐tethered substrate provided a helically chiral aza[6]helicene.
Solid‐Phase Synthesis of Macrocyclic Peptides via Side‐Chain Anchoring of the Ornithine δ‐Amine
Authors: Peterse Evert , Meeuwenoord Nico , van den Elst Hans , van der Marel Gijsbert A. , Overkleeft Hermen S. , Filippov Dmitri V. 
Published: December 2021

AbstractCyclic peptides represent a popular class of macrocyclic drug candidates and therefore their solid phase synthesis has attracted much attention. In this contribution we present an efficient method of side‐chain anchoring for ornithine and lysine residues to be used in the standard Fmoc‐based synthesis of cyclic peptides via on‐resin cyclization. We demonstrate that the side chain of ornithine and lysine protected with N‐Boc‐group can efficiently be converted to the isocyanate which is then immobilized on Wang‐type resin in almost quantitative yield. We further show the synthesis of four biologically active cyclic peptides employing the side chain ornithine anchoring. Our method is at least on a par with the previously reported methodologies in terms of yield and the purity of the final products and is arguably operationally more straightforward.
Cobalt‐Mediated Decarboxylative/Desilylative C−H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues
Authors: Chen Kang , Lv Shan , Lai Ruizhi , Yang Zhongzhen , Hai Li , Nie Ruifang , Wu Yong 
Published: December 2021

AbstractA Co(II)‐mediated decarboxylative/desilylative C−H activation/annulation reaction for the efficient synthesis of 3‐arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforward routes for the synthesis of natural alkaloids and novel structural analogues.
Use of transcutaneous electrical nerve stimulation along with functional tasks for immediate pain relief in individuals with knee osteoarthritis
Authors: Lawson Daryl , Degani Adriana M. , Lee Kevin , Beer Emily I. , Gohlke Katelyn E. , Hamidi Kevin N. , Coler Mitchell A. , Tews Nolan M. 
Published: December 2021

AbstractBackgroundKnee pain is the major complaint in individuals with knee osteoarthritis (OA), and the effects of transcutaneous electrical nerve stimulation (TENS) on knee pain are controversial. The present study applied TENS along with functional tests to investigate its effect on pain level in individuals with mild‐to‐moderate knee OA.MethodsTwenty volunteers with knee OA classification of graded 2–3 performed four functional tests (stair climb test [SCT], timed up and go test [TUG], 6‐minute walk test [6‐MWT], knee extensor strength test [KES], and 2‐step test from the locomotive syndrome risk test [LSR_2ST]) while wearing either an active or inactive TENS. Knee pain level before and after each test was self‐accessed by the Visual Analogue Scale (VAS). The effect of TENS (active vs. inactive) on pain level was submitted to statistical analyses.ResultsKnee pain during SCT, TUG, and LSR_2ST tests was significantly lower when subjects used the active TENS, compared with using the inactive unit. The effect of the active TENS on pain level was also more significant in subjects with no anxiety or depression.ConclusionsThe results provided evidence of immediate pain relief in individuals with mild‐to‐moderate knee OA when TENS is applied along with functional activities, that usually induced pain in people with knee OA.SignificanceThe use of transcutaneous electrical nerve stimulation (TENS) in pain management is still unclear. In this study, the analgesic effects of TENS in people with knee osteoarthritis (OA) were found effective when applied along with functional activities. Therefore, study findings provided clinical evidence for the use of TENS during functional activities as a conservative approach to reduce knee OA pain.
Insight into energy dissipation behavior of a SDOF structure controlled by the pounding tuned mass damper system
Authors: Zhang Jingcai , Zhang Chunwei , Xue Qichao 
Published: December 2021

AbstractThe purpose of this paper is to present an innovative insight into the behavior and energy dissipation mechanism of a single‐degree‐of‐freedom (SDOF) structure controlled by pounding tuned mass damper (PTMD). In this study, a shake table test was conducted to investigate energy response of the SDOF structure incorporated with PTMD and subjected to seismic excitations. Moreover, SDOF structure and the updated analytical structural pounding force model based on viscoelasticity of materials have been investigated for parametric studies, including dynamic parameters of the primary structure, properties of PTMD, and characteristics of the earthquake records. The influence of these parameters has been discussed in details in this paper. The results showed that energy can be dissipated by PTMD as well as via the three traditional ways of TMD. The energy dissipated by PTMD keeps increasing during excitation, which is similar to the process of energy dissipated by damping mechanism. Furthermore, energy dissipated by damping and PTMD are nearly equal, and the two types of energy dissipation predominate the behavior of the system. Hysteretic, recoverable elastic strain and kinetic energy of the controlled structure diminish to very low level during earthquakes.
New apatite‐type oxide ion conductors Ce9.33+xSi6O26+δ: Structures, phase stabilities, electrical properties, and conducting mechanisms
Authors: Wei Tianjie , Xu Jungu , Zhu Wenfeng 
Published: December 2021

AbstractApatite‐type rare earth silicate with high oxygen ion conductivity are attractive materials for their wide potential applications, such as being used in solid oxide fuel cells as electrolytes. Herein, a series of new apatite‐type oxide ion conductors Ce9.33+xSi6O26+δ (x = 0.43, 0.67, 1.03) have been prepared, with their phases, stabilities, electrical properties, and conducting mechanisms been thoroughly studied. The results reveal that these materials are stable under inert or reducing atmospheres, but decomposed under an oxidizing environment at elevated temperatures. The combined alternative current and directive current techniques reveal dominating oxide ion conductions and minor electronic conductions in them. The bond‐valence‐based method is applied to investigate the possible oxide ion migration pathways and disclose the main contribution from interstitial oxygens, which locate between two neighboring tetrahedral SiO4 units and enable the oxide ion transporting among them along the c‐axis direction, whereas the intrinsic channel oxygens show an inferior responsibility for the oxide ion conductivities.
Multi- and Trans-Generational Effects on Daphnia Magna of Chlorpyrifos Exposures
Authors: Maggio Stephanie A. , Jenkins Jeffrey J. 
Published: December 2021

Abstract
Chlorpyrifos, a broad-spectrum neurotoxic organophosphate insecticide, is subject to atmospheric and hydrolytic transport from application sites to aquatic ecosystems. Across the landscape, concentrations in surface water can vary spatially and temporally according to seasonal use practices. Standardized bioassays can provide a screening-level understanding of aquatic receptor acute and chronic toxicity. However, these bioassays do not address ecologically relevant exposure patterns that may impact fitness and survival within and across generations. The aim of the present study was to evaluate the utility of a second-tier, screening-level methodology employing Daphnia magna multi- and transgenerational bioassays spanning four generations to investigate the effect of variable chronic chlorpyrifos exposure. The multigenerational assay consisted of continuous chlorpyrifos exposure across four consecutive 21-day bioassays using progeny from the previous assay for each successive generation. In the transgenerational assay, only the parent (F0) generation was exposed. For both assays, survival and reproduction were assessed across treatments and generations. Results indicated that (1) following continuous chlorpyrifos exposure at ecologically relevant concentrations to four generations of D. magna, the highest treatment showed an apparent tolerance response for both survival and reproductive success in the F3 generation, and (2) chlorpyrifos exposure to the F0 generation did not result in treatment effects in the unexposed F1, F2, and F3 generations in the apical endpoints of survival and reproduction. Employing a suite of acute and chronic bioassays, including chronic exposures spanning multiple generations, allows for a more robust screening-level evaluation of the potential impact of chlorpyrifos on aquatic receptors for variable periods of exposure. Environ Toxicol Chem 2022;41:1054–1065. © 2021 SETAC
A dynamic scenario‐driven technique for stock price prediction and trading
Authors: Thesia Yash , Oza Vidhey , Thakkar Priyank 
Published: December 2021

AbstractIt has always been a challenge to accurately forecast the behavior of a stock market due to its extremely nonlinear and dynamic nature. Numerous studies have shown that technical indicators describing stocks in conjunction with machine learning models can serve as useful tools for forecasting in the stock market. There are various challenges, and one of them is the choice of the right technical indicators and prediction models. It is believed that there is no optimal set of technical indicators that work well in all market scenarios in a dynamic environment such as the stock market. The statement also applies to different prediction models. There is no definite winner, and different settings can emerge as winners in different market scenarios. On this premise, we propose DSdT: a dynamic scenario‐driven technique for stock price prediction and trading strategy enhancement. The proposed novel technique uses the scenario recognition and integration module to identify and integrate the current market scenario into the forecasting pipeline, resulting in a scenario‐driven stock price prediction. We use a large set of technical indicators and a shallow neural network equipped with a gating mechanism to capture and integrate the current market scenario in the prediction process. Experiments are performed on 11 stocks of the Indian Stock Market. The proposed approach yields mean absolute percentage error (MAPE) of 1.67%compared with 2.4%of its closest nonscenario‐driven counterpart for the next day's stock price prediction task. A trading strategy is also devised using the proposed technique, and the returns are compared with different baselines. Results show that the devised trading strategy yields an approximate average return of 54%compared with 25%of the return obtained by the nearest benchmark.
Are option traders more informed than Twitter users? A PVAR analysis
Authors: Frino Alex , Xu Caihong , Zhou Z. Ivy 
Published: December 2021

AbstractPrior research has examined whether Twitter information predicts stock returns and volatility. We study the causality between Twitter information, stock‐realized volatility, and option‐implied volatility using a panel vector autoregressive model. Using panel data on S&P/ASX 200 stocks, we reveal a bidirectional causality between realized volatility and Twitter activity and divergence of opinion. We also find strong evidence of causality from implied idiosyncratic volatility to Twitter activity, sentiment, and divergence of opinion. Our results highlight the role of the options market in predicting Twitter information and monitoring social media flows to prevent the spread of fake news.
Influence of ramped pressure gradient on transient flow formation in a horizontal porous channel
Authors: Jha Basant K. , Yunus Zainab Sa'id 
Published: December 2021

AbstractThe transient flow formation in a horizontal porous channel assuming a ramped pressure gradient is presented. The equation governing the flow is modeled into a partial differential equation (PDE) which is solved by employing the Laplace transformation technique to transform the PDE to an ordinary differential equation (ODE). The obtained ODE is solved by employing the method of undetermined coefficients to obtain the velocity profile in the Laplace domain. The Riemann sum approximation technique is then adopted to change the obtained solution from the Laplace domain into the time domain. For accuracy checks, the numerical results of the obtained equation are reckoned with previously published work, and an excellent agreement is found. For a clearer understanding of the impact of various flow parameters entering the solutions obtained, graphical and tabular representations are offered using MATLAB software. We noticed that the velocity is slower with ramped pressure gradient compared to a constant pressure gradient. This is because the motion of the fluid occurs gradually with ramped pressure gradient.
Cyanidin‐3‐glucoside protects against high glucose‐induced injury in human nucleus pulposus cells by regulating the Nrf2/HO‐1 signaling
Authors: Bai Xiaoliang , Lian Yong , Hu Changqing , Yang Shuai , Pei Bo , Yao Mingyan , Zhu Xiaojuan , Shang Lin , Li Zhihong 
Published: December 2021

AbstractCyanidin‐3‐glucoside (C3G) is a well‐known natural anthocyanin with antioxidant and anti‐inflammatory properties. In this study, we explored the role and action mechanism of C3G in high glucose (HG)‐induced damage of human nucleus pulposus cells (HNPCs). Cell viability was assessed by CCK‐8 assay. TUNEL assay was performed for detecting apoptotic rate. Western blot was performed to determine the expression levels of cl‐caspase‐3, caspase‐3, Bax, Bim, collagen II, aggrecan, MMP‐3, MMP‐13, and ADAMTS5. Reactive oxygen species (ROS) generation was analyzed using DCFH‐DA staining. The Nrf2 was knocked down or overexpressed in HNPCs through transfection with si‐Nrf2 or pcDNA3.0‐Nrf2. C3G treatment (12.5, 25, and 50 μM) improved cell viability of HNPCs under HG condition. HG‐induced cell apoptosis of HNPCs was attenuated by C3G with decreased apoptotic rate and relative levels of cl‐caspase‐3/caspase‐3, Bax, and Bim. C3G treatment caused significant increase in expression levels of collagen II and aggrecan and decrease in the relative levels of MMP‐3, MMP‐13, and ADAMTS5. After treatment with C3G, ROS generation in HNPCs was markedly reduced. Treatment with N‐acetylcysteine (NAC) reversed HG‐induced cell apoptosis and extracellular matrix (ECM) degradation. C3G treatment induced the expression of Nrf2 and HO‐1 in HG‐induced HNPCs. Moreover, knockdown of Nrf2 reversed the inhibitory effect of C3G on ROS production. Summarily, C3G exerted a protective effect on ROS‐mediated cellular damage in HNPCs under HG condition, which was attributed to the induction of the Nrf2/HO‐1 signaling pathway.
Effect of m6A methyltransferase METTL3 ‐mediated MALAT1/E2F1/AGR2 axis on adriamycin resistance in breast cancer
Authors: Li Sumei , Jiang Fengru , Chen Feiyu , Deng Yingzhao , Pan Xiaoping 
Published: December 2021

AbstractN6‐methyladenosine (m6A) methyltransferase METTL3 has been implicated in carcinogenesis, which may be associated the overexpression of MALAT1. However, the downstream mechanics actions remain largely unknown. This study intends to probe the downstream mechanism of the N6‐methyladenosine (m6A) methyltransferase METTL3 and MALAT1 in adriamycin resistance in breast cancer. Through Bioinformatics databases lncMAP, TCGA and GTEx, we predicted the downstream transcription factors E2F1 and AGR2 of MALAT1 in breast cancer. The Cancer Genome Atlas and Genotype‐Tissue Expression (GTEx) databases were used to screen the downstream target genes of MALAT1. MeRIP‐qPCR was used to detect the m6A level of MALAT1 in cells. RIP was used to detect the binding between MALAT1 and E2F1, and chromatin immunoprecipitation (ChIP) for the binding of E2F1 to AGR2 promoter. Cell Counting Kit‐8 and colony formation assays were used to detect cell viability. Transwell was used to detect cell invasion. Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) and western blot were used to detect the expression of related genes and proteins. A nude mouse xenograft tumor model was established to observe the effect of METTL3 on adriamycin resistance of breast cancer. The total survival of mice after exogenous gene silencing was analyzed by the Kaplan–Meier method. METTL3 was highly expressed in adriamycin‐resistant breast cancer cells. METTL3 promotes adriamycin resistance in breast cancer cells. METTL3 mediates the expression of MALAT1 in adriamycin‐resistant breast cancer through m6A. MALAT1 increases adriamycin resistance in breast cancer cells by recruiting E2F1 to activate AGR2 transcription. METTL3 can regulate the expression of MALAT1 through m6A, mediate the E2F1/AGR2 axis, and promote the adriamycin resistance of breast cancer. METTL3 may modify MALAT1 protein through m6A, recruit E2F1 and activate downstream AGR2 expression, thus promoting adriamycin resistance in breast cancer.
Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentation
Authors: Gad Sameh S. , Abdelrahim Dina S. , Ismail Sameh H. , Ibrahim Sherine M. 
Published: December 2021

AbstractNanoparticles are recently playing a potential role in improving drug uptake and the treatment of diseases. A variety of nanoparticles, such as selenium nanoparticles (SeNPs) and silver nanoparticles (AgNPs) have been used as drug carriers in various ways for treatment of cancers and liver diseases. Our aim in this study is to investigate the ability of AgNPs and SeNPs to target and treat the viral and bacterial infection of the liver in rats and cell lines. For assessment of antioxidant activity of AgNPs in rats with induced liver bacterial infection, six adult male albino rats were included in this study, liver slices were taken and assigned to 6 groups. Markers of hepatic functions, oxidative stress, and inflammation in liver slices are carried out. Although for assessment of antiviral activity of SeNPs, hepatitis B virus transfected (HBV)‐replicating human cell line HepG2 and normal hepatocyte cells were used, hepatic and inflammatory alterations are determined through quantitative polymerase chain reaction and comet assay techniques. The effect of AgNPs on interleukin‐6 and tumor necrosis factor levels were reduced in different treated groups with AgNPs compared with the control and diseased groups. On the other hand, SeNPs revealed significant alterations in the inflammatory markers as well as DNA damage in the treated HBV‐human cell line HepG2 compared to the diseased ones. AgNPs have the ability for producing various hepatic alterations and can inhibit the proliferation of hepatic stellate cells (HSCs) in a dose and size‐dependent manner. On the other hand, SeNPs showed excellent selectivity towards viral cells in the HepG2 cell lines. Both AgNPs and SeNPs might be promising drug designs for treating viral and bacterial liver diseases.