bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINUS BRADYCARDIA AS AN EARLY MARKER OF HEART DAMAGE IN A GIRL WITH LYME DISEASE (CASE REPORT AND MINI REVIEW)
Authors: Nykytyuk S. , Klymnyuk S. , Levytska L. 
Published: June 2021

Objectives Early clinical markers of Lyme carditis and other life-threatening prognostic factors due to complications of borreliа infection are still the beginning of active research by scientists. The literature describes a small number of cases of Lyme carditis with arrhythmias or cardiac conduction disorders. Material and methods We reviewed the case of a 14-year-old girl. LC was diagnosed on the basis of history of disease, physical examination, laboratory examination data (positive anti-borrelia IgM in ELISA with confirmation in immunoblot. The presence of B. burgdorferi s.l. was detected by the method of immunoassay analysis using the Euroimmun AG test systems (Germany). The presence of B. burgdorferi s.l. was detected by the method of immunoassay analysis using the Euroimmun AG test systems (Germany). 2 instrumental methods: (ECG,Echo-cor) were used. Results We described a case of Lyme borreliosis in a 14-year-old girl, accompanied by sinus bradyarrhythmia and pericardial fluid -(hydropericardium) (passed after a course of antibacterial therapy). Analysis of this case indicates early detection and adequate treatment of Lyme carditis in young people with minimal deviations of the cardiogram. A case of Lyme carditis , in a child was confirmed.Echocardiography of the heart (at the time of admission to the hospital andat the time of discharge from the hospital was made.
Conclusions 1. Lyme carditis should be suspected in patients with a history of Lyme disease and minimal Electrocardiographic abnormalities , such as sinus bradycardia. 2. For differential diagnosis of Lyme carditis, it is necessary to make ( carry out two-stage serological investigation of blood, especially using antibody screening tests by ELISA with subsequent confirmation by the Western blot assay.
Looking Through Palme’s Vision for the Global Environment
Authors: Sundström Anna 
Published: June 2021

Olof Palme, the former Prime Minister of Sweden, underlined the importance of a firm global response to the growing environmental crisis in his 06 June 1972 address to the first UN Conference on the Human Environment (UNCHE) held in Stockholm. He prophetically observed: “it is absolutely necessary that concerted, international action is undertaken … solutions will require far-reaching changes in attitudes and social structures”. Almost 50 years later, it is painfully clear that the necessary changes have not taken place and that time is now even more limited to make the necessary, far-reaching changes. How can the conclusions from the Stockholm Conference and ideas envisioned by Olof Palme can guide us into a better common greener future?
Preventive Behaviors Related to Covid-19 Among High School Students: Cross-Sectional Web-Based Survey
Authors: Muntahaya Fika , Batuah Thoriq Fajar , Nisa Hoirun 
Published: June 2021

The increase in COVID-19 cases encourages the need for health efforts from various sectors. The number of COVID-19 confirmed cases in Palangka Raya City is the highest in Central Kalimantan province. The Ministry of Education urged the implementation of 3M education, such as wearing masks, washing hands, and social distancing, to stop the transmission of COVID-19. This study aims to describe the level of knowledge, attitudes, and preventive behaviors related to COVID-19 and the association between knowledge and attitudes with preventive behaviors related to COVID-19 in students of MAN Kota Palangka Raya. This research is a cross-sectional study that involved 339 students as respondents. Data was collected using google form in October 2020. 98.8% of students had good knowledge of COVID-19, and 87.0% of students had positive attitudes about preventing COVID-19, but only 54.6% of students had good preventing behaviors related to COVID-19. Association was found between attitudes toward COVID-19 with preventive behaviors related to COVID-19 in MAN Palangka Raya City students in 2020. 3M's preventive behavior education efforts still need to be improved to stop the transmission of COVID-19.
Neoplasia Endócrina Múltipla Tipo 1: Um relato de caso
Authors: Fortes Yasmine Maria Leódido , Fontenelle Gustavo Eduardo Pires , Erudilho Eduardo , Zamignan Reno Leite , Bergamini Bárbara Raveena Diniz , Almeida Rebeca Matos de 
Published: June 2021

Objetivo: Discorrer a cerca de um caso de rara ocorrência de neoplasia endócrina múltipla tipo 1 e discutir aspectos relacionados à importância do diagnóstico precoce. Métodos: Informações obtidas por vias de revisão do prontuário, entrevista com o paciente, registro fotográfico dos exames aos quais o paciente foi submetido. Relato de caso: Mulher, 60 anos, história pregressa de amenorreia secundária desde os 18 anos. À época, procurou ginecologista, no qual foi verificado hiperprolactinemia e prescrito bromocriptina. Ficou sem acompanhamento endocrinológico por aproximadamente quarenta anos, quando foi encaminhada para consulta especializada. Em consulta, observado hiperprolactinemia, hipercalcemia e PTH elevado. Além de exames de imagem com microadenoma hipofisário, nódulos na tireoide, pancreáticos e adrenais. Já com o diagnóstico clínico de NEM1, atualmente a paciente e alguns familiares estão sendo convocados para coleta de material genético para análise e provável detecção de perfil de mutação. Considerações finais: Foi possível concluir que o NEM-1 se não diagnosticado no início pode causar síndromes hormonais importantes, assim como é importante considerá-la dentre os diagnósticos diferenciais.
Associação de esteatose hepática em pacientes em pré-operatório de cirurgia bariátrica com apneia obstrutiva do sono
Authors: Frare Letícia , Pantano Alves Daniela , Farias Isabela Resende , Medeiros Giuliana Moreira de , Soares Carolina Ferraz de Paula 
Published: June 2021

A apneia obstrutiva do sono (AOS) é uma doença global que se associa à síndrome metabólica, especialmente à obesidade. A hipoxemia intermitente decorrente da AOS pode levar a um aumento na resistência à insulina e a uma alteração no metabolismo lipídico, podendo precipitar o desenvolvimento de esteatose hepática, caracterizada pelo acúmulo de lipídeos no interior dos hepatócitos, considerada provável causa principal de morbidade e mortalidade ligada a doenças do fígado. Dessa forma, este estudo retrospectivo buscou avaliar uma possível relação entre a AOS e a esteatose hepática em pacientes obesos no pré-operatório para cirurgia bariátrica. A partir da coleta de dados de 1.416 prontuários de pacientes em avaliação pré-operatória, obteve-se dados dos exames de ultrassonografia (USG) e polissonografia (PSG), resultando em uma amostra de 87 indivíduos avaliados. Desta amostra, 61% dos indivíduos eram do sexo feminino, com idade média de 39 anos de idade, com desvio padrão (d.p.) de 11,4 e IMC de 39.3 (d.p. 4,4). A ultrassonografia classificou como portadores de esteatose hepática 74 indivíduos (85%). O valor médio do Índice de apneia-hipopneia (IAH) foi de 33.5 (d.p. 28.9) e do Índice de dessaturação da oxihemoglobina (IDO) foi de 41.4 (d.p. 34,1). Os pacientes foram divididos em 2 grupos: um grupo com IAH menor ou igual 15 eventos/hora e outro com IAH maior ou igual 16 eventos/hora. O grau de esteatose diferiu entre os grupos pelo IAH (p <0,001) e sexo (p <0,001). Após o ajuste de várias variáveis por meio de regressão múltipla, apenas o sexo masculino foi um preditor de graus mais elevados de esteatose. Concluímos que há maior prevalência de esteatose hepática entre portadores de AOS, sendo que os principais fatores associados a esteatose foram o IAH e sexo masculino, porém após regressão apenas o sexo feminino seria preditor de proteção à esteatose na amostra estudada.
Experience and sexuality education in creation of audiovisual installation
Authors: Muclisin Alif Sukma 
Published: June 2021

Experience and education on sexuality is a unity of things / events experienced by individuals / groups regarding sex and sexuality which are then reduced to an informal educational structure. The purpose of this research is to explain the concept of artwork that underlies the creation of the audiovisual installation and the process of visualization of artwork on the creation of audiovisual installation. The media for creating works that are applied is an audiovisual installation art. Inspired by the previous works of Julian Rosefeldt (Manifesto), Gerda Wegener (Solitaire), Mella Jaarsma (Potong Waktu) and Halsey (Album Manic). The method of creation is based on Laura H. Chapman's theory with three stages, namely Inception of Idea, Elaboration and Refinement, and Execution in a Medium.
Obesidade infantil: Uma problemática da sociedade atual
Authors: Zigarti Pedro Victor Ramos , Barata Junior Idelmar da Silva , Ferreira José Carlos de Sales 
Published: June 2021

Introdução: É observado ao decorrer das últimas décadas que houve um crescimento no mundo todo da obesidade infantil, e devido ao seu evidente crescimento ela vem se caracterizando como uma nova epidemia mundial Objetivo: analisar os aspectos que cercam a obesidade infantil e a sua prevalência na sociedade atual. Metodologia: Este estudo trata-se de uma pesquisa de revisão integrativa da literatura. Resultados e Discussão: A obesidade, já na infância, está relacionada a várias complicações, como também a uma maior taxa de mortalidade. E, quanto mais tempo o indivíduo se mantém obeso, maior é a chance de as complicações ocorrerem, assim como mais precocemente. Conclusão: Ações no âmbito coletivo devem envolver políticas públicas que promovam a saúde, o bem-estar e a qualidade de vida das populações.
Heterogeneity in Regional Damage Detected by Neuroimaging and Neuropathological Studies in Older Adults With COVID-19: A Cognitive-Neuroscience Systematic Review to Inform the Long-Term Impact of the Virus on Neurocognitive Trajectories
Authors: Manca Riccardo , De Marco Matteo , Ince Paul G. , Venneri Annalena 
Published: June 2021

Background: Other than its direct impact on cardiopulmonary health, Coronavirus Disease 2019 (COVID-19) infection affects additional body systems, especially in older adults. Several studies have reported acute neurological symptoms that present at onset or develop during hospitalisation, with associated neural injuries. Whilst the acute neurological phase is widely documented, the long-term consequences of COVID-19 infection on neurocognitive functioning remain unknown. Although an evidence-based framework describing the disease chronic phase is premature, it is important to lay the foundations for future data-driven models. This systematic review aimed at summarising the literature on neuroimaging and neuropathological findings in older over-60 patients with COVID-19 following a cognitive neuroscientific perspective, to clarify the most vulnerable brain areas and speculate on the possible cognitive consequences.Methods: PubMed and Web of Science databases were searched to identify relevant manuscripts published between 1st March 2020 and 31th December 2020. Outputs were screened and selected by two assessors. Relevant studies not detected by literature search were added manually.Results: Ninety studies, mainly single cases and case series, were included. Several neuroimaging and neuropathological findings in older patients with COVID-19 emerged from these studies, with cerebrovascular damage having a prominent role. Abnormalities (hyperintensities, hypoperfusion, inflammation, and cellular damage) were reported in most brain areas. The most consistent cross-aetiology findings were in white matter, brainstem and fronto-temporal areas. Viral DNA was detected mainly in olfactory, orbitofrontal and brainstem areas.Conclusion: Studies on COVID-19 related neural damage are rich and diverse, but limited to description of hospitalised patients with fatal outcome (i.e., in neuropathological studies) or severe symptoms (i.e., in neuroimaging studies). The damage seen in this population indicates acute and largely irreversible dysfunction to neural regions involved in major functional networks that support normal cognitive and behavioural functioning. It is still unknown whether the long-term impact of the virus will be limited to chronic evolution of acute events, whether sub-clinical pathological processes will be exacerbated or whether novel mechanisms will emerge. Based on current literature, future theoretical frameworks describing the long-term impact of COVID-19 infection on mental abilities will have to factor in major trends of aetiological and topographic heterogeneity.
Retreatment With Flow Diverters and Coiling for Recurrent Aneurysms After Initial Endovascular Treatment: A Propensity Score-Matched Comparative Analysis
Authors: Li Wenqiang , Zhu Wei , Sun Xinguo , Liu Jian , Wang Yang , Wang Kun , Zhang Ying , Yang Xinjian , Zhang Yisen 
Published: June 2021

Background: Flow diverters and conventional coiling are established modalities for the retreatment of intracranial recurrent aneurysms after initial endovascular treatment. We aimed to compare the efficacy of these techniques.Methods: We retrospectively analyzed data for patients with recurrent aneurysms after initial endovascular treatment retreated in our center with either a pipeline embolization device (PED) or conventional coil embolization from January 2012 to July 2020. We performed 1:2 propensity score matching (PSM) using the nearest neighbor method. We controlled for: initial treatment strategy, aneurysm size, neck diameter, symptom presentation, history of aneurysm rupture, age, sex, fusiform-dissecting aneurysm, bifurcation aneurysm, and aneurysm location. The clinical and morphological factors of all patients at initial treatment and the angiographic and clinical results at the second treatment were collected and compared between the propensity-matched pairs.Results: A total of 105 intracranial aneurysms were identified; 18 patients (17.1%) were treated with a PED, and 87 (82.9%) were treated via conventional coil embolization. PSM resulted in 12 matched pairs (12 patients in the PED group and 24 in the coiling group). There was no significant difference of ischemic and hemorrhagic complications between the groups, the obliteration rate of branches covered by stent, or modified Rankin Scale scores at the last clinical follow-up. Importantly, the retreatment strategy in the PED group provided significantly different results vs. the coiling group (P &lt; 0.001), with a lower recurrence rate (0.0 vs. 29.2%, respectively; P = 0.037). However, the procedural failure rate and the parent artery stenosis were more frequently in PED group compared with coiling group (both were 16.7 vs. 0.0%; P = 0.040).Conclusions: Endovascular retreatment for recurrent aneurysms after initial endovascular treatment might be safe and effective. Flow diverters might be associated with reduced risk of recanalization and an increased risk of procedural failure and mild parent artery stenosis.
Effect of Hyperbaric Oxygen Therapy on Polarization Phenotype of Rat Microglia After Traumatic Brain Injury
Authors: Liang Fang , Kang Nan , Li Pinpin , Liu Xuehua , Li Ge , Yang Jing 
Published: June 2021

Background: The neurological defect caused by secondary damage following traumatic brain injury (TBI) is considered critical for the management of TBI. Microglia (MG) are a resident brain macrophage that could differentiate into M1 type or M2 type in response to injury and repair. It is known that the MG transition from M1 phenotype to anti-inflammatory M2 phenotype might reduce secondary injury of TBI. So, a TBI animal model was established and we compared biomarkers of M1 and M2MG between the controls and experimental animals receiving hyperbaric oxygen therapy (HBOT). This study aimed to explore whether HBOT was an effective method to improve neural functional recovery via promoting the polarization of MG into M2 after TBI.Methods: The rats were randomly divided into four groups: SH (Sham-operated), SH + HBO (hyperbaric oxygen), TBI, and TBI + HBO. Each group included 42 rats, and each of these were divided into the following groups: 1, 6, 12, 24, 72 h, 7, and 14 days. The expression of M1 biomarker inducible nitric oxide synthase (iNOS), M2 biomarker arginase 1 (Arg1), associated cytokine tumor necrosis factor-α (TNF-α), and transforming growth factor-β1 (TGF-β1) was evaluated after the observation time.Results: TBI significantly increased the expression levels of M1 marker iNOS and M2 markers Arg1 at different time points. The increased expression of iNOS was suppressed, while the expression level of Arg1 was enhanced by HBOT. Moreover, HBOT suppressed the pro-inflammatory TNF-α secreted by M1, and promoting the anti-inflammatory TGF-1β.Conclusions: In the present study, HBOT showed the effects on shift of M1 toward M2 phenotype with increased expression of M2 biomarkers and decreased expression of M1 biomarkers in the early stage after TBI.
Knowledge Domain and Emerging Trends in Ferroptosis Research: A Bibliometric and Knowledge-Map Analysis
Authors: Zhang Jie , Song Luxia , Xu Liyan , Fan Yixuan , Wang Tong , Tian Wende , Ju Jianqing , Xu Hao 
Published: June 2021

ObjectivesTo identify the cooperation and impact of authors, countries, institutions, and journals, evaluate the knowledge base, find the hotspot trends, and detect the emerging topics regarding ferroptosis research.MethodsThe articles and reviews related to ferroptosis were obtained from the Web of Science Core Collection on November 1, 2020. Two scientometric software (CiteSpace 5.7 and VOSviewer 1.6.15) were used to perform bibliometric and knowledge-map analysis.ResultsA total of 1,267 papers were included, in 466 academic journals by 6,867 authors in 438 institutions from 61 countries/regions. The ferroptosis-related publications were increasing rapidly. Cell Death &amp; Disease published the most papers on ferroptosis, while Cell was the top co-cited journal, publication journals and co-cited journals were major in the molecular and biology fields. The United States and China were the most productive countries; meanwhile, the University of Pittsburgh, Columbia University and Guangzhou Medical University were the most active institutions. Brent R Stockwell published the most papers, while Scott J Dixon had the most co-citations; simultaneously, active cooperation existed in ferroptosis researchers. Ten references on reviews, mechanisms, and diseases were regarded as the knowledge base. Five main aspects of ferroptosis research included regulation mechanisms, nervous system injury, cancer, relationships with other types of cell death, and lipid peroxidation. The latest hotspots were nanoparticle, cancer therapy, iron metabolism, and in-depth mechanism. Notably Nrf2 might have turning significance. The emerging topics on ferroptosis research were the further molecular mechanism of ferroptosis and the wider application of ferroptosis-related disease with advanced technology.ConclusionThis study performed a full overview of the ferroptosis research using bibliometric and visual methods. The information would provide helpful references for scholars focusing on ferroptosis.
First Speleomycological Study on the Occurrence of Psychrophilic and Psychrotolerant Aeromycota in the Brestovská Cave (Western Tatras Mts., Slovakia) and First Reports for Some Species at Underground Sites
Authors: Ogórek Rafał , Speruda Mateusz , Borzęcka Justyna , Piecuch Agata , Cal Magdalena 
Published: June 2021

Most underground ecosystems are heterotrophic, fungi in these objects are dispersed in the air in the form of spores, and they may be potentially hazardous to mammals. Research in underground sites has focused on mesophilic airborne fungi and only a few concerned cold-adapted species. Therefore, the goal of our research was the first report of psychrophilic and psychrotolerant aeromycota in the Brestovská Cave using culture-based techniques with genetic and phenotypic identification. Plates with PDA medium containing sampled biological material were incubated at 8 ± 0.5 °C. The density of mycobiota inside the cave ranged from 37.4 to 71 CFU 1 m−3 of air and 63.3 CFU 1 m−3 of air outside the cave. Thus, the level of fungal spores did not exceed the standards for the mycological quality of the air. A total of 18 species were isolated during the study, and some species may be potentially dangerous to people with weakened immune system. All fungal species were present inside the cave and only seven of them were outside. Cladosporium cladosporioides dominated in the external air samples and Mortierella parvispora was cultured most frequently from internal air samples. To our knowledge, this is the first discovery of the fungal species such as Coniothyrium pyrinum, Cystobasidium laryngis, Filobasidium wieringae, Leucosporidium drummii, M. parvispora, Mrakia blollopis, Nakazawaea holstii, and Vishniacozyma victoriae in the air inside the underground sites. Moreover, C. pyrinum, C. laryngis, L. drummii, M. blollopis, and N. holstii have never been detected in any component of the underground ecosystems. There are possible reasons explaining the detection of those species, but global warming is the most likely.
Inhibition of Mycotoxigenic Fungi in Different Vegetable Matrices by Extracts of Trichoderma Species
Authors: Stracquadanio Claudia , Luz Carlos , La Spada Federico , Meca Giuseppe , Cacciola Santa Olga 
Published: June 2021

Post-harvest fungal diseases of plant products are a serious concern leading to economic losses and health risks. Moreover, the use of synthetic chemical fungicides to prevent these diseases is limited due to toxic residues. This study aimed at determining the effective dose of extracts of Trichoderma asperellum IMI393899 (TE1) and Trichoderma atroviride TS (TE2) in inhibiting the contamination by mycotoxigenic fungi on different plant matrices. Extracts were tested on tomatoes contaminated by Fusarium verticillioides and Fusarium graminearum, wheat contaminated by Penicillium verrucosum and maize contaminated by Aspergillus flavus. The efficacy of extracts was evaluated at two time intervals after treatment, 4 and 11 days for tomato, and 10 and 20 days for both wheat and maize. Both extracts showed a significant inhibitory activity on mycotoxigenic pathogens and significantly reduced Log CFU/g compared to the control. Moreover, the extracts reduced mycotoxin production in a dose dependent manner and with a long-lasting effect. The ochratoxin A was reduced by both extracts but only the extract TE2 was effective in reducing aflatoxins, whereas TE1 treatment increased their synthesis.
SIKAP MAHASISWA KEPADA DOSEN SELAMA PROSES BELAJAR MENGAJAR
Authors: Rustam Aji , Ruslina Yulaika 
Published: June 2021

Mahasiswa dari berbagai daerah berkumpul dalamkehidupan kampus, yang merupakan salah satu sasaran strategis terjadinya degradasi moral dan etika perilaku. Etika Perilaku mahasiswa kepada dosennya mengalami penurunan dari masa ke masa. Sebagai warga kampus mahasiswa akan berkomunikasi dengan dosen. Dalam hubungannya ini, etika dalam berperilaku akan berperan penting dan menuntut tingkah laku untuk bersikap baik. Penelitian bertujuan mengetahui pentingnya mahasiswa bersikap terhadap dosen pada saat proses belajar mengajar berlangsung didalam kelas dan lingkungan kampus. Lokasi penelitian di kampus, penelitian jenis kualitatif. Hasil diketahui bahwa informan seluruh (100%) pernah melanggar peraturan kampus. Sebagian dari (66,67 %) pernah satu kali melanggar peraturan kampus.Sebagian (66,67%) pernah membaca buku peraturan mahasiswa. Sebagian (66,67%) pernah satu kali di tegur dosen. Hampir seluruh (83,33%) pernah langsung di nasehati, dibimbing dan diarahkan. Setengah (50%) pernah membaca buku peraturan mahasiswa.Sebagian (66,67%) memahami arti sikap.Sebagian (66,67%) Pernah satu kali didalam kelas saat belajar.Hampir seluruh (83,33%) pernah satu kali di tegur dosen. Sebaiknya peraturan akademik sikap mahasiswa tertulis, di tempel di dalam kampus.