bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring outpatient antibiotic utilization using reimbursement and retail sales data: a population-based comparison in France, 2012–17
Authors: Trinh Nhung T. H. , Chalumeau Martin , Bruckner Tim A. , Levy Corinne , Bessou Antoine , Milic Dejan , Cohen Robert , Lemaitre Magali , Cohen Jérémie F. 
Published: May 2021

Abstract

Objectives
To assess whether a retail sales database could be used to monitor antibiotic utilization in the outpatient setting at the national level.

Methods
We extracted 2012–17 outpatient antibiotic extrapolated retail sales (IQVIA’s Xponent) and reimbursement data from the National Health Insurance (SNDS) in metropolitan France. We compared estimates of antibiotic use and consumption [number of antibiotic drug deliveries (DrID) and defined daily doses (DID) per 1000 inhabitants per day]. We relied on relative differences, Pearson’s r statistics and time series using autoregressive integrated moving average (ARIMA) modelling to study: (i) differences in point estimates, (ii) correlation, and (iii) consistency in time trends between Xponent and SNDS. The analysis was conducted overall and in subgroups (age groups, therapeutic classes, major antimicrobial agents and regions).

Results
We analysed approximately 377 million antibiotic drug deliveries, comprising nearly 3.4 billion DDDs. Overall, Xponent slightly overestimated SNDS point estimates with yearly relative differences of +3.5% for DrID and +3.3% for DID. Peaks in relative differences were observed for July and August months. Relative differences were &lt;5% in most subgroups, except for fosfomycin and three French regions. Overall and across most subgroups, the correlation between Xponent and SNDS monthly aggregated estimates was almost perfect (r ≥ 0.992 for all subgroups, except for one region). ARIMA modelling showed high consistency between Xponent’s and SDNS’s DrID time series, but detected timepoints where the series significantly diverged.

Conclusions
IQVIA’s Xponent and SNDS data were highly consistent. Xponent database seems suitable for monitoring outpatient antibiotic utilization in France.
Molecular and genomic epidemiology of VIM/IMP-like metallo-β-lactamase-producing Pseudomonas aeruginosa genotypes in Poland
Authors: Urbanowicz P. , Izdebski R. , Baraniak A. , Żabicka D. , Hryniewicz W. , Gniadkowski M. 
Published: May 2021

Abstract

Objectives
To identify key factors of the expansion of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) in Poland, focusing on the role of clonal epidemic(s).

Methods
MPPA isolates were typed by PFGE, followed by MLST. blaVIM/IMP MBL genes were amplified and sequenced within class 1 integrons. Their location was assessed by S1 nuclease-hybridization assays. Short-read WGS was performed, and genomes were subjected to SNP-based phylogenetic and resistome analyses.

Results
Of 1314 MPPA isolates collected in 2005–15 from 212 hospitals, 454 representatives were selected. The isolates belonged to 120 pulsotypes and 52 STs, of which ST235 (∼31%), ST111 (∼17%), ST273 (∼16%) and ST654 (∼9%) prevailed, followed by ST244, ST17, ST395, ST175 and ST1567. The isolates produced seven VIM variants (97.5%) and four IMPs encoded by 46 integrons, most of which were observed only or mainly in Poland. Around 60% of the isolates resulted from (inter)regional clonal outbreaks of 10 individual ST235, ST111, ST273 and ST654 genotypes. The phylogenetic analysis of 163 genomes revealed heterogeneity of ST235 and ST111 populations, arising from transnational circulation and on-site differentiation of several clades/branches. Contrarily, ST273 and ST654 formed relatively homogeneous and apparently Poland-specific lineages, and a unique ST273 genotype with integron In249 was the most expansive organism.

Conclusions
Together with a previous report on self-transmissible In461-carrying IncP-2-type plasmids, this study revealed the molecular/genomic background of the rapid MPPA increase in Poland in 2001–15, evidencing multi-clonal spread as its leading factor. Numerous novel/specific MPPA characteristics were identified.
Mining Consumer Minds: Downstream Consequences of Host Motivations for Home-Sharing Platforms
Authors: Chung Jaeyeon (Jae) , Johar Gita Venkataramani , Li Yanyan , Netzer Oded , Pearson Matthew 
Published: May 2021

AbstractThis research sheds light on consumer motivations for participating in the sharing economy and examines downstream consequences of the uncovered motivations. We use text-mining techniques to extract Airbnb hosts’ motivations from their responses to the question “why did you start hosting.” We find that hosts are driven not only by the monetary motivation “to earn cash” but also by intrinsic motivations such as “to share beauty” and “to meet people.” Using extensive transaction-level data, we find that hosts with intrinsic motivations post more property photos and write longer property descriptions, demonstrating greater engagement with the platform. Consequently, these hosts receive higher guest satisfaction ratings. Compared to hosts who want to earn cash, hosts motivated to meet people are more likely to keep hosting and to stay active on the platform, and hosts motivated to share beauty charge higher prices. As a result, these intrinsically motivated hosts have a higher customer lifetime value compared to those with a monetary motivation. We employ a multimethod approach including text mining, Bayesian latent attrition models, and lab experiments to derive these insights. Our research provides an easy-to-implement approach to uncovering consumer motivations in practice and highlights the consequential role of these motivations for firms.
Impact of Triflumuron onHalyomorpha halys(Hemiptera: Pentatomidae): Laboratory and Field Studies
Authors: Masetti Antonio , Depalo Laura , Pasqualini Edison 
Published: May 2021

AbstractHalyomorpha halys, (the brown marmorated stink bug, BMSB), is a high-concern invasive species causing severe damage to orchards in many countries outside its native Asian range. Control options matching both effectiveness and sustainability are currently lacking. Inhibitors of chitin biosynthesis might be exploited for integrated management programs because of the overall better ecotoxicological profile in comparison with most neurotoxic insecticides used so far against BMSB. In this study, the activity of triflumuron, a benzoylphenyl urea hampering chitin biosynthesis, was tested on BMSB in laboratory and field conditions. In laboratory bioassays, the insecticide was sprayed on potted peach plants (30 cm high) and residues were aged in a glasshouse for 0, 7, 14, and 21 d. Then, third-instar bugs were placed on the plants and continuously exposed to residues. Mortality was scored after 7, 14, and 21 d exposure. Triflumuron caused significantly higher mortality on BMSB nymphs in comparison with water controls at all aging periods. Moreover, aging of residues up to 21 d did not cause any significant reduction of activity. Field experiments were also carried out in 2019 in eight pear orchards. Injuries to fruits at harvest were compared between plots where triflumuron was added to insecticide sprays against BMSB and control plots managed exactly in the same way but without any triflumuron treatment. An overall mean of 9.99 ± 1.98% stink bug injured fruits was detected in plots managed with the strategy including triflumuron, whereas 19.45 ± 3.55% of fruits were injured in plots assigned to controls.
From Extra-Territorial Leverage and Transnational Environmental Protection to Distortions of Competition: The Level Playing Field in the EU–UK Trade and Cooperation Agreement
Authors: Leonelli Giulia Claudia 
Published: May 2021

Abstract
This article inquires to what extent the European Union (EU)–UK Trade and Cooperation Agreement (TCA) may help safeguard high levels of transnational environmental protection, taking into consideration potential reductions in UK levels of protection and the ensuing effects. The article encompasses an analysis of the Trade and Sustainable Development (TSD) Chapters in recent EU trade or trade and investment Agreements (FTAs); in this respect, it emphasises that the TCA’s provisions are innovative. However, the TCA has marked a shift from the EU’s initial attempts to exercise its extra-territorial leverage and push for high levels of transnational environmental protection to a focus on the stricto sensu economic level playing field. This narrow focus cannot possibly capture many aspects of environmental protection. The article thus concludes that, from an environmental perspective, the TCA’s provisions are far from ambitious. Further, it develops some considerations on the way forward for the EU institutions, as they start to rethink their approach to TSD Chapters.
Reading the Mahābhārata as Śāstra: The Role of the ‘Righteous’ Pāṇḍavas and ‘Villainous’ Kauravas in Madhva's Dvaitavedānta
Authors: Sharma Vishal 
Published: May 2021

AbstractThe Sanskrit Mahābhārata is considered to be a śāstra in Mādhva Vaiṣṇavism, and Madhva composed one of the earliest treatises dedicated to explaining the Mahābhārata’s deeper meaning. In doing so, he pays careful attention to the distinction between the righteous Pāṇḍavas and corrupt Kauravas—a distinction that exists in theory if not always in practice. How does Madhva demarcate the Kauravas and the Pāṇḍavas, and why does this matter for his own theology? Looking at two episodes that either blur or upend the demarcation of the Kauravas and Pāṇḍavas, the mace-battle between Bhīma and Duryodhana (9.60) and the Pāṇḍavas’ journey to heaven (17-18.3), this article shows how Madhva’s Mahābhāratatātparyanirṇaya explains key tenets of Madhva’s ontology and theology. When read carefully, each episode brings out important features of Madhva’s doctrine of devatātāratamya—the gradation of gods. Rather than simply understanding Madhva’s commentary as a theologisation or vedānticisation of the narrative, I argue that his exegesis itself develops and explains central doctrines of Dvaitavedānta, particularly tāratamya and aparokṣajñāna. Vedānticization, in this understanding then, is not simply bringing forth an interpretation of the narrative that fits one's prior philosophical commitments, but it is a process of constituting theology through the narrative.
Universal forensic DNA databases: acceptable or illegal under the European Court of Human Rights regime?
Authors: Tuazon Oliver M 
Published: May 2021

Abstract
Universal forensic DNA databases are controversial privacy-wise given their omnibus scope of incorporating DNA profile data of the entire population into the system. Following the landmark decision of the European Court of Human Rights on the retention of DNA profiles in S. and Marper v. the United Kingdom, two differing opinions emerged on its application to universal databases: their acceptability and illegality. This paper makes use of the elements of the right to respect for private life (Article 8 ECHR), distilled from the Court’s jurisprudence involving collection and retention of DNA profile data, in the form of tests—preliminary interference, legality, legitimate purpose, and proportionality—in assessing the feasibility of establishing population-wide DNA databases in Europe.
A rare case of pancreatic head hydatid cyst
Authors: Qarmo Muhammad M , Aldirani Alaa N , Al-Boukhari Lynn M J , Moussa Faisal M , Alkhateeb Lama A 
Published: May 2021

Abstract
Hydatidosis or Echinococcosis is a parasitic disease caused by infection with the larval stage of Echinococcus granulosus. Primary isolated pancreatic hydatidosis is very rare even in countries where echinococcosis disease is highly endemic. The objective of this case report is to highlight this unusual and rare hydatid cyst presentation to avoid incorrect diagnosis and management. In our case, preoperative evaluation guided the diagnosis toward cystic pancreatic neoplasms, leading us to contemplate a radical surgical approach (Pancreaticoduodenectomy). Pancreatic hydatid cysts can be confused with cystic pancreatic neoplasms, it should always be considered as a differential diagnosis in endemic areas, to prevent misdiagnosis and inappropriate management.
Fresnel models for gravitational wave effects on pulsar timing
Authors: McGrath Casey , Creighton Jolien 
Published: May 2021

ABSTRACT
Merging supermassive black hole binaries produce low-frequency gravitational waves, which pulsar timing experiments are searching for. Much of the current theory is developed within the plane-wave formalism, and here we develop the more general Fresnel formalism. We show that Fresnel corrections to gravitational wave timing residual models allow novel measurements to be made, such as direct measurements of the source distance from the timing residual phase and frequency, as well as direct measurements of chirp mass from a monochromatic source. Probing the Fresnel corrections in these models will require future pulsar timing arrays with more distant pulsars across our Galaxy (ideally at the distance of the Magellanic Clouds), timed with precisions less than 100 ns, with distance uncertainties reduced to the order of the gravitational wavelength. We find that sources with chirp mass of order 109 M⊙ and orbital frequency ω0 &gt; 10 nHz are good candidates for probing Fresnel corrections. With these conditions met, the measured source distance uncertainty can be made less than 10 per cent of the distance to the source for sources out to ∼100 Mpc, source sky localization can be reduced to sub-arcminute precision, and source volume localization can be made to less than 1 Mpc3 for sources out to 1-Gpc distances.
The hybrid radio/X-ray correlation of the black hole transient MAXI J1348–630
Authors: Carotenuto F , Corbel S , Tremou E , Russell T D , Tzioumis A , Fender R P , Woudt P A , Motta S E , Miller-Jones J C A , Tetarenko A J , Sivakoff G R 
Published: May 2021

ABSTRACT
Black hole (BH) low mass X-ray binaries in their hard spectral state are found to display two different correlations between the radio emission from the compact jets and the X-ray emission from the inner accretion flow. Here, we present a large data set of quasi-simultaneous radio and X-ray observations of the recently discovered accreting BH MAXI J1348–630 during its 2019/2020 outburst. Our results span almost six orders of magnitude in X-ray luminosity, allowing us to probe the accretion–ejection coupling from the brightest to the faintest phases of the outburst. We find that MAXI J1348–630 belongs to the growing population of outliers at the highest observed luminosities. Interestingly, MAXI J1348–630 deviates from the outlier track at LX ≲ 7 × 1035(D/2.2  kpc)2 erg s−1 and ultimately rejoins the standard track at LX ≃ 1033(D/2.2 kpc)2 erg s−1, displaying a hybrid radio/X-ray correlation, observed only in a handful of sources. However, for MAXI J1348–630 these transitions happen at luminosities much lower than what observed for similar sources (at least an order of magnitude). We discuss the behaviour of MAXI J1348–630 in light of the currently proposed scenarios and highlight the importance of future deep monitorings of hybrid correlation sources, especially close to the transitions and in the low luminosity regime.
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
Authors: Lindeman Robin E , Murphy Mark W , Agrimson Kellie S , Gewiss Rachel L , Bardwell Vivian J , Gearhart Micah D , Zarkower David 
Published: May 2021

Abstract
Mammalian sexual development commences when fetal bipotential progenitor cells adopt male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these cells involves extensive divergence in chromatin state and gene expression, reflecting distinct roles in sexual differentiation and gametogenesis. Surprisingly, differentiated gonadal cell fates require active maintenance through postnatal life to prevent sexual transdifferentiation and female cell fate can be reprogrammed by ectopic expression of the sex regulator DMRT1. Here we examine how DMRT1 reprograms granulosa cells to Sertoli-like cells in vivo and in culture. We define postnatal sex-biased gene expression programs and identify three-dimensional chromatin contacts and differentially accessible chromatin regions (DARs) associated with differentially expressed genes. Using a conditional transgene we find DMRT1 only partially reprograms the ovarian transcriptome in the absence of SOX9 and its paralog SOX8, indicating that these factors functionally cooperate with DMRT1. ATAC-seq and ChIP-seq show that DMRT1 induces formation of many DARs that it binds with SOX9, and DMRT1 is required for binding of SOX9 at most of these. We suggest that DMRT1 can act as a pioneer factor to open chromatin and allow binding of SOX9, which then cooperates with DMRT1 to reprogram sexual cell fate.
DGLinker: flexible knowledge-graph prediction of disease–gene associations
Authors: Hu Jiajing , Lepore Rosalba , Dobson Richard J B , Al-Chalabi Ammar , M. Bean Daniel , Iacoangeli Alfredo 
Published: May 2021

Abstract
As a result of the advent of high-throughput technologies, there has been rapid progress in our understanding of the genetics underlying biological processes. However, despite such advances, the genetic landscape of human diseases has only marginally been disclosed. Exploiting the present availability of large amounts of biological and phenotypic data, we can use our current understanding of disease genetics to train machine learning models to predict novel genetic factors associated with the disease. To this end, we developed DGLinker, a webserver for the prediction of novel candidate genes for human diseases given a set of known disease genes. DGLinker has a user-friendly interface that allows non-expert users to exploit biomedical information from a wide range of biological and phenotypic databases, and/or to upload their own data, to generate a knowledge-graph and use machine learning to predict new disease-associated genes. The webserver includes tools to explore and interpret the results and generates publication-ready figures. DGLinker is available at https://dglinker.rosalind.kcl.ac.uk. The webserver is free and open to all users without the need for registration.
The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression
Authors: Fang Yuan , Tang Yin , Zhang Yanjun , Pan Yixin , Jia Junqi , Sun Zhongxing , Zeng Weiwu , Chen Jiaqi , Yuan Ying , Fang Dong 
Published: May 2021

Abstract
Epigenetics, especially histone marks, functions beyond the DNA sequences to regulate gene expression. Depletion of NSD1, which catalyzes H3K36me2, leads to both up- and down-regulation of gene expression, indicating NSD1 is associated with both active and repressed gene expression. It's known that NSD1 regulates the deposition and expansion of H3K27me3, a repressive mark for gene expression, to keep active gene transcription. However, how NSD1 functions to repress gene expression is largely unknown. Here, we find that, when NSD1 is knocked out in mouse embryonic stem cells (mESCs), H3K27ac increases correlatively with the decrease of H3K36me2 at active enhancers, which is associated with mesoderm differentiation genes, leading to elevated gene expression. Mechanistically, NSD1 recruits HDAC1, the deacetylase of H3K27ac, to chromatin. Moreover, HDAC1 knockout (KO) recapitulates the increase of H3K27ac at active enhancers as the NSD1 depletion. Together, we propose that NSD1 deposits H3K36me2 and recruits HDAC1 at active enhancers to serve as a ‘safeguard’, preventing further activation of active enhancer-associated genes.
Tackling Smoker Misperceptions About E-cigarettes Using Expert Videos
Authors: Svenson Madeleine , Green James , Maynard Olivia M 
Published: May 2021

AbstractBackgroundThe pervasive misperception that e-cigarettes are equally or more harmful than combustible cigarettes is a barrier to current smokers switching to e-cigarettes. To tackle misperceptions, public health bodies are using informational videos, although their efficacy is unknown.MethodsIn our online study, current UK smokers who do not vape (n = 382) were randomized to view either: (1) a Cancer Research UK (CRUK) text-only video; (2) a video featuring leading e-cigarette experts (expert); or (3) a no video control condition, and then completed questions regarding e-cigarette harm perceptions.ResultsCompared to the control condition, participants in the CRUK condition, and especially those in the expert condition had more accurate harm perceptions of e-cigarettes and had more accurate knowledge of e-cigarette constituents. In the expert condition, 67% of individuals reported they would try an e-cigarette in a future quit attempt, compared with 51% in the CRUK condition and 35% in the control condition.ConclusionsOur findings are encouraging in the face of mounting evidence that e-cigarette misperceptions are increasing. Whilst misperceptions are often characterized as resistant to correction, we find that carefully designed public health information videos have the potential to promote a more accurate, informed view of e-cigarettes, and encourage intended e-cigarette use among UK smokers. Importantly, we find this among current smokers who do not vape, a group often reported as having the highest levels of misperceptions and as having the most to gain from accurate e-cigarette perceptions.ImplicationsThere is mounting evidence that e-cigarette misperceptions are increasing, particularly among smokers who do not vape, a group who have most to gain from accurate information about e-cigarettes. Misperceptions are often characterized as difficult to change and there is relatively little research on how to correct e-cigarette misperceptions. Our research in the UK shows that, compared to controls, e-cigarette misperceptions can be corrected among those smokers who are shown carefully constructed expert videos. This work has important implications for the development and dissemination of these important messages.
Identification and utilization of genetic determinants of trait measurement errors in image-based, high-throughput phenotyping
Authors: Zhou Yan , Kusmec Aaron , Mirnezami Seyed Vahid , Attigala Lakshmi , Srinivasan Srikant , Jubery Talukder Z. , Schnable James C. , Salas-Fernandez Maria G. , Ganapathysubramanian Baskar , Schnable Patrick S. 
Published: May 2021

AbstractThe accuracy of trait measurements greatly affects the quality of genetic analyses. During automated phenotyping, trait measurement errors, i.e. differences between automatically extracted trait values and ground truth, are often treated as random effects that can be controlled by increasing population sizes and/or replication number. In contrast, there is some evidence that trait measurement errors may be partially under genetic control. Consistent with this hypothesis, we observed substantial nonrandom, genetic contributions to trait measurement errors for five maize (Zea mays) tassel traits collected using an image-based phenotyping platform. The phenotyping accuracy varied according to whether a tassel exhibited “open” versus. “closed” branching architecture, which is itself under genetic control. Trait-associated SNPs (TASs) identified via genome-wide association studies (GWASs) conducted on five tassel traits that had been phenotyped both manually (i.e. ground truth) and via feature extraction from images exhibit little overlap. Furthermore, identification of TASs from GWASs conducted on the differences between the two values indicated that a fraction of measurement error is under genetic control. Similar results were obtained in a sorghum (Sorghum bicolor) plant height dataset, demonstrating that trait measurement error is genetically determined in multiple species and traits. Trait measurement bias cannot be controlled by increasing population size and/or replication number.