bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Stress Hyperglycemia on Short-Term Prognosis of Patients Without Diabetes Mellitus in Coronary Care Unit
Authors: Zhang Luming , Wang Zichen , Xu Fengshuo , Han Didi , Li Shaojin , Yin Haiyan , Lyu Jun 
Published: May 2021

Background: Diabetes mellitus (DM) has a high morbidity and mortality worldwide, and it is a risk factor for cardiovascular diseases. Non-diabetic stress hyperglycemia is common in severely ill patients, and it could affect prognosis. This study aimed to analyze the influence of different blood glucose levels on prognosis from the perspective of stress hyperglycemia by comparing them with normal blood glucose levels and those of patients with DM.Methods: A retrospective study of 1,401 patients in coronary care unit (CCU) from the critical care database called Medical Information Mart for Intensive Care IV was performed. Patients were assigned to the following groups 1–4 based on their history of DM, random blood glucose, and HbA1c levels: normal blood glucose group, moderate stress hyperglycemia group, severe stress hyperglycemia group and DM group. The main outcome of this study was 30- and 90-day mortality rates. The associations between groups and outcomes were analyzed using Kaplan–Meier survival analysis, Cox proportional hazard regression model and competing risk regression model.Results: A total of 1,401 patients in CCU were enrolled in this study. The Kaplan–Meier survival curve showed that group 1 had a higher survival probability than groups 3 and 4 in terms of 30- and 90-day mortalities. After controlling the potential confounders in Cox regression, groups 3 and 4 had a statistically significant higher risk of both mortalities than group 1, while no difference in mortality risk was found between groups 2 and 1. The hazard ratios [95% confidence interval (CI)] of 30- and 90-day mortality rates for group 3 were 2.77(1.39,5.54) and 2.59(1.31,5.12), respectively, while those for group 4 were 1.92(1.08,3.40) and 1.94(1.11,3.37), respectively.Conclusions: Severe stress hyperglycemia (≥200 mg/dL) in patients without DM in CCU may increase the risk of short-term death, which is greater than the prognostic effect in patients with diabetes. Patients with normal blood glucose levels and moderate stress hyperglycemia (140 mg/dL ≤ RBG &lt;200 mg/dL) had no effect on short-term outcomes in patients with CCU.
A Preliminary Study of Quantitative Ultrasound for Cancer-Risk Assessment of Thyroid Nodules
Authors: Goundan Poorani N. , Mamou Jonathan , Rohrbach Daniel , Smith Jason , Patel Harshal , Wallace Kirk D. , Feleppa Ernest J. , Lee Stephanie L. 
Published: May 2021

BackgroundGray-scale, B-mode ultrasound (US) imaging is part of the standard clinical procedure for evaluating thyroid nodules (TNs). It is limited by its instrument- and operator-dependence and inter-observer variability. In addition, the accepted high-risk B-mode US TN features are more specific for detecting classic papillary thyroid cancer rather than the follicular variant of papillary thyroid cancer or follicular thyroid cancer. Quantitative ultrasound (QUS) is a technique that can non-invasively assess properties of tissue microarchitecture by exploiting information contained in raw ultrasonic radiofrequency (RF) echo signals that is discarded in conventional B-mode imaging. QUS provides quantitative parameter-value estimates that are a function of the properties of US scatterers and microarchitecture of the tissue. The purpose of this preliminary study was to assess the performance of QUS parameters in evaluating benign and malignant thyroid nodules.MethodsPatients from the Thyroid Health Center at the Boston Medical Center were recruited to participate. B-mode and RF data were acquired and analyzed in 225 TNs (24 malignant and 201 benign) from 208 patients. These data were acquired either before (167 nodules) or after (58 nodules) subjects underwent fine-needle biopsy (FNB). The performance of a combination of QUS parameters (CQP) was assessed and compared with the performance of B-mode risk-stratification systems.ResultsCQP produced an ROC AUC value of 0.857 ± 0.033 compared to a value of 0.887 ± 0.033 (p=0.327) for the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR TI-RADS) and 0.880 ± 0.041 (p=0.367) for the American Thyroid Association (ATA) risk-stratification system. Furthermore, using a CQP threshold of 0.263 would further reduce the number of unnecessary FNBs in 44% of TNs without missing any malignant TNs. When CQP used in combination with ACR TI-RADS, a potential additional reduction of 49 to 66% in unnecessary FNBs was demonstrated.ConclusionThis preliminary study suggests that QUS may provide a method to classify TNs when used by itself or when combined with a conventional gray-scale US risk-stratification system and can potentially reduce the need to biopsy TNs.
Management of Donor-Specific Antibodies in Haploidentical Transplant: Multicenter Experience From the Madrid Group of Hematopoietic Transplant
Authors: Bailén Rebeca , Vicario José Luis , Solán Laura , Sánchez-Vadillo Irene , Herrera Pilar , Calbacho María , Alenda Raquel , López-Lorenzo José Luis , Humala Karem , Chinea Anabelle , Sánchez-Pina José , Balas Antonio , Moreno Miguel Ángel , Arzuaga Javier , Pradillo Virginia , Dorado Nieves , Oarbeascoa Gillen , Anguita Javier , Díez-Martín José Luis , Kwon Mi 
Published: May 2021

BackgroundDonor specific antibodies (DSAs) can be responsible for graft failure (GF) in the setting of mismatched hematopoietic stem cell transplantation (HSCT). The aim of our study is to report the experience of the Madrid Group of Hematopoietic Transplant (GMTH) in patients with DSAs undergoing haplo-HSCT.MethodsPatients undergoing haplo-HSCT in centers from the GMTH from 2012 to 2020 were included in the study. DSAs were analyzed with a solid-phase single-antigen immunoassay; monitoring was performed during desensitization on days -14, -7, 0 and in a weekly basis until neutrophil engraftment. Desensitization strategies varied depending on center experience, immunofluorescence intensity, complement fixation and type of antibodies.ResultsWe identified a total of 20 haplo-HSCT in 19 patients performed with DSAs in 5 centers. 10 (53%) patients presented anti-HLA class I DSAs (6 of them with &gt; 5000 mean fluorescence intensity (MFI)), 4 (21%) presented anti-HLA class II (1 with &gt; 5000 MFI) and 5 (26%) presented both anti-HLA class I and II (5 with &gt; 5000 MFI). 90% of patients received at least two treatments as desensitization strategy and all experienced a decrease of MFI after desensitization (mean reduction 74%). Only one patient who developed progressive increase of MFI after infusion developed GF. Desensitization treatments used included rituximab, immunoglobulins, therapeutic plasma exchange, incompatible platelets, buffy coat and immunosuppressors. Seventeen (90%) patients achieved neutrophil engraftment; one patient died before engraftment because of infection and one patient with class I DSAs developed primary GF despite an intensive desensitization. After a median follow-up of 10 months, OS and EFS were 60% and 58%, respectively, cumulative incidence of relapse was 5% and NRM was 32%.ConclusionsDespite the optimal strategy of DSAs desensitization remains unclear, the use of desensitization treatment guided by DSAs intensity kinetics constitute an effective approach with high rates of engraftment for patients with DSAs in need for an haplo-HSCT lacking an alternative suitable donor.
Enhancing the Screening Efficiency of Breast Cancer by Combining Conventional Medical Imaging Examinations With Circulating Tumor Cells
Authors: Gao Yang , Fan Wan-Hung , Duan Chaohui , Zhao Wenhe , Zhang Jun , Kang Xixiong 
Published: May 2021

PurposeUltrasound (US) and mammogram (MMG) are the two most common breast cancer (BC) screening tools. This study aimed to assess how the combination of circulating tumor cells (CTC) with US and MMG would improve the diagnostic performance.MethodsCTC detection and imaging examinations, US and MMG, were performed in 238 treatment-naive BC patients, 217 patients with benign breast diseases (BBD), and 20 healthy females. Correlations of CTC, US and MMG with patients’ clinicopathological characteristics were evaluated. Diagnostic performances of CTC, US and MMG were estimated by the receiver operating characteristic curves.ResultsCTC, US and MMG could all distinguish BC patients from the control (p &lt; 0.0001). Area under curve (AUC) of CTC, US and MMG are 0.855, 0.861 and 0.759, respectively. While US has the highest sensitivity of 0.79, CTC and MMG have the same specificity of 0.92. Notably, CTC has the highest accuracy of 0.83. Combination with CTC increases the AUC of US and MMG to 0.922 and 0.899, respectively. Combining MMG with CTC or US increases the sensitivity of MMG to 0.87, however “CTC + MMG” has a higher specificity of 0.85. “CTC + US” performs the best in BC diagnosis, followed by “CTC + MMG” and then “US + MMG”.ConclusionCTC can be used as a diagnostic aid for BC screening. Combination with CTC increases the diagnostic potency of conventional BC screening imaging examinations, US and MMG, in BC diagnosis, especially for MMG.
Calcitonin Gene-Related Peptide Monoclonal Antibodies Versus Botulinum Neurotoxin a in the Preventive Treatment of Chronic Migraine: An Adjusted Indirect Treatment Comparison Meta-Analysis
Authors: Chen Yao-Yao , Ye Xiao-Qian , Tang Tai-Chun , She Tian-Wei , Chen Min , Zheng Hui 
Published: May 2021

Purpose: Calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are new agents approved by the US Food and Drug Administration for preventive treatment of chronic migraine. Comparison between CGRPmAbs and previously approved Botulinum neurotoxin A (BoNT-A) will inform optimal preventive treatment of chronic migraine, but head-to-head trials are lacking. We therefore aimed to perform adjusted indirect comparison between CGRPmAbs and BoNT-A through a meta-analysis.Methods: OVID MEDLINE, EMBASE and the Cochrane central register of controlled trials, clinical registries, and government websites were searched from inception to September 2019. Randomized controlled trials comparing CGRPmAbs or BoNT-A with placebo in the preventive treatment of chronic migraine were included. The primary outcomes were headache days and migraine days measured at week 12. Data were synthesized by using a frequentist approach; and the treatments were ranked by P-score.Results: We included 10 trials (n = 4,678) after screening 1049 candidates. Six trials were with low risk of bias. Fremanezumab had an effect similar to BoNT-A in the reduction of headache days at week 12 (standard mean difference [SMD] 0.08, 95%CI -0.55 to -0.7). Galcanezumab reduced more migraine days than BoNT-A at week 12 (SMD, -0.94, 95%CI −1.24 to −0.63); fremanezumab showed similar findings (SMD, −0.55, 95%CI −0.85 to −0.24). Galcanezumab and fremanezumab had better effect in mitigating headache impact at week 12. CGRPmAbs and BoNT-A had similar adverse event rate.Conclusion: CGRPmAbs and BoNT-A had similar effect in the preventive treatment of chronic migraine. BoNT-A might be preferentially selected owing to its cost-effectiveness profiles. Further studies with direct comparison of the two treatments are warranted.
Not the Cryptic Species: Diversity of Hipposideros gentilis (Chiroptera: Hipposideridae) in Indochina
Authors: Yuzefovich Alexander P. , Artyushin Ilya V. , Kruskop Sergei V. 
Published: May 2021

We present here the result of phylogenetic analysis for Vietnamese Hipposideros gentilis specimens using 7 nuclear genes and one mitochondrial gene. The complex distribution of divergent mitochondrial DNA lineages contradicts, at least in part, nuclear and morphological data. The most likely explanation for this discordance is the historical hybridization between ancestral populations of H. gentilis and H. rotalis/H. khaokhouayensis. Our data supports the species status of H. gentilis, while only partially corroborating its previously proposed subspecies delimitation. We suggest the lowland forest populations from south Vietnam may correspond to their own subspecies. At the same time, the close phylogenetic relationship and morphological similarity of mountain forms from south and central Vietnam to the north Vietnamese populations make doubtful the subspecies status of H. gentilis sinensis.
Influence of Chrysoporthe deuterocubensis Canker Disease on the Physical and Mechanical Properties of Eucalyptus urograndis
Authors: Dahali Rasdianah , Md. Tahir Paridah , Roseley Adlin Sabrina Muhammad , Hua Lee Seng , Bakar Edi Suhaimi , Ashaari Zaidon , Abdul Rauf Mohd Redzuan , Zainuddin Nur Aziera , Mansoor Noor Syazwani 
Published: May 2021

Eucalyptus hybrid has been planted rigorously in wet tropical regions including Malaysia. Recently, there was a report on the occurrence of stem canker on these trees. However, the extent of the infections by this stem canker is unknown. The aim of this study was to evaluate the influence of stem canker disease, Chrysoporthe deuterocubensis, on the physical and mechanical properties of 11-year-old E. urophylla × E. grandis or also known as E. urograndis. The samples were taken from infected and healthy trees that were segregated into different classes based on the severity of the attack, i.e., healthy (class 1), moderately infected (class 2), severely infected (class 3) and very severely infected (class 4). A total of 1440 samples from four infection classes were used in this study. The physical and mechanical properties were determined according to the standard test procedures specified by the International Organization for Standardization (ISO) 13061:2014 (Parts 1 to 4, 13, 14 and 17) and British Standard (BS 373: 1957). From the result, a significant effect by the infection classes was observed on physical and mechanical properties of E. urograndis. All infected wood experienced less shrinkage compared to that of a healthy one, particularly the volumetric (Volsh) and radial shrinkage (Rsh). Wood from class 2 and class 3 was less affected by the infection while the majority of wood from class 4 had significantly lower density and poorer strength. Based on the strength data, wood from infection class 2 can be considered to be used for non-structural applications such as furniture, interior finishing, window frames and doors since reduction in mechanical properties was observed. Wood from class 3 would need further investigation to examine its suitability for structural applications.
Derechos de la infancia y género en México
Authors: Pochetti Irene 
Published: May 2021

A partir de un trabajo de campo etnográfico llevado a cabo en las ciudades de México
y Tijuana entre 2003 y 2013, este estudio analiza las articulaciones entre la política de
atención de la “infancia callejera”, las transformaciones democráticas y las políticas
económicas de corte neoliberal desplegadas durante la primera década del año 2000 en
México. La reflexión propone, por un lado, preguntarse cómo se articularon los conte nidos de la Convención sobre Derechos del Niño (CDN) con la noción de Estado y las
políticas públicas de la época. Por el otro lado, responderemos a la pregunta de cómo
los recursos discursivos y legislativos que refieren a los derechos de las/os niñas/os, y en
particular su interpretación sexuada (enfoque de género), son apropiados y traducidos
por los distintos actores que trabajan con niñas/os y adolescentes en situación de calle.
Alejandro y los otros retratos de la Galería de Niños de América del Instituto Interamericano del Niño
Authors: Ribeiro Fernanda Bittencourt 
Published: May 2021

En este artículo se interpreta la categoría “infancia latinoamericana” a par
-
tir del análisis de la Galería de Niños de América creada en la década de
1970 por el Instituto Interamericano del Niño, la Niña y Adolescentes (IIN).
Se considera que los cuadros que la componían constituyen una perspectiva
privilegiada para el análisis de la producción de imágenes de la infancia y los
ideales de modernidad difundidos por dicho organismo. El análisis destaca
la coexistencia, en el marco del sistema de protección interamericano, de la
afirmación de un “niño del mundo”, por encima de las pertenencias locales
y las inversiones simbólicas que producen la especificidad de la región. Se
argumenta que este conjunto de cuadros genera el efecto de alejar la niñez,
dicha desamparada y portadora del futuro del continente, de la imagen de
la infancia irregular y del niño peligroso. Vista desde esta galería, la infancia
latinoamericana aparece asociada a la imagen de un niño solo, algo indefenso,
pero digno y necesitado de apoyo.
Perspektif Kepuasan Penumpang Dalam Kualitas Pelayanan Kapal Feri: Studi Kasus Pelabuhan Penyeberangan Merak-Bakauheni
Authors: Herno Della Rhaptyalyani , Rachmannullah Ashari Fitra 
Published: May 2021

This study evaluates passenger satisfaction from the perspective of service quality. The sample was collected by sending questionnaires from two perspectives; ferry passengers and ferry company employees at Merak-Bakauheni port in Indonesia. The PZB model is used for gap analysis and SERVQUAL dimension to assess and evaluate the service quality. The results show gaps between passenger satisfaction and ferry service quality at the Merak port - Bakauheni port. Data analysis using t-pairwise statistical method. The analysis found that gap 1; gap in perspective between the passenger expectations service and the ferry companies perceptions of their passengers expectation is very large, with the largest attributes from tangibles dimension. The largest gap of attributes from that dimension is “convenience store at the terminal.” In gap 5, the perceptions of passengers' expected and their perceived of service showed that the attribute of “Ferry service provides online services to facilitate customers” as the largest gap. Thus, from this study, ferry services need to make reformation, especially in the attribute that has a large gap. Moreover, this study provides an overview to ferry service in Indonesia to enhance their service quality.
Base Shear Struktur Beton Bertulang Yang Menggunakan Base Isolator Akibat Beban Gempa Dengan Menggunakan Etabs
Authors: Nggaba Dicky N. , Simatupang Partogi H , Rizal A. Hidayat 
Published: May 2021

The sudden release of energy within earth creates seismic waves on earth’s surface that is earthquake. This research was carried out using a base isolator type of HDR with Certification Number MVBR-0516 (XO.3R) to reduce base shear, displacement and internal forces acting on the structure. This study uses time history analysis method with some earthquake loads in the form of acceleration acceleration. The objectives of the study were to determine the base shear of a reinforced concrete structure building using a base isolator and without using a base insulator. The results of this study indicate the use of base insulators reduces base shear by about 20% -67% and 14% -70.5% for earthquakes in the x direction to the east and west. Meanwhile, in the y direction earthquake, it was around 43% -70% and 43% -62% to the south and north
Studi Fenomenologi: Problematika Mahasiswa Asing Belajar Statistika di Perguruan Tinggi
Authors: Blegur Irna Karlina Sensiana 
Published: May 2021

Penelitian ini bertujuan mendeskripsikan problematika mahasiswa asing belajar statistika pada perguruan tinggi di Indonesia dan penyebabnya. Penelitian ini merupakan penelitian deskriptif eksploratif dengan pendekatan kualitatif fenomenologi. Data dikumpulkan dengan menggunakan angket bebas, teknik wawancara dan dokumentasi. Sumber data adalah lima mahasiswa asing penerima beasiswa KNB (Kemitraan Negara Berkembang scholarships) pada salah satu universitas negeri di Yogyakarta. Analisis data dilakukan dengan mencari subtema, kemudian menentukan hubungan antar subtema untuk memperoleh pemahaman. Adapun hasil penelitian adalah sebagai berikut: pertama, mahasiswa sulit belajar Stastika karena bahasa pengantar yang digunakan. Kedua mahasiswa sulit belajar Stastika karena ketersediaan prior knowledge yang tidak memadai. Ketiga, mahasiswa sulit belajar statistika karena teknik penyajian materi yang digunakan ketika perkuliahan
POLÍTICAS DE QUALIFICAÇÃO PARA OS TRABALHADORES DE TURISMO NO MARANHÃO
Authors: Correia Jonilson Costa , Leite Angela Roberta Lucas , Soares Patrícia Natália dos Santos 
Published: May 2021

Este estudo analisa políticas de qualificação para os trabalhadores do setor de turismo no Maranhão sob a ótica do Programa Mais Qualificação da Secretaria de Estado do Turismo. Esta pesquisa tem como objetivos específicos identificar ações do programa; verificar dificuldades enfrentadas pelo programa Mais Qualificação e Turismo durante a execução e desvelar as perspectivas do programa. Esta foi uma pesquisa qualitativa com uma abordagem exploratório-descritiva, analisando assim os dados empíricos e teóricos referente ao tema; a entrevista foi a técnica de coleta de dados aplicada aos gestores públicos que executam o programa. Com isso, foi possível concluir que, a qualificação para o segmento turístico é um diferencial competitivo e, além disso, leva a aprendizagem de novos conhecimentos, habilidades e competências exigidas pelo mercado de trabalho turístico, o que o caracteriza, também, uma estratégia de reprodução das exigências do capital.
Experience of haematological observatory ward during COVID-10 pandemic
Authors: Gavrilina O. A. , Vasileva A. N. , Galstyan G. M. , Tupoleva T. A. , Tikhomirov D. S. , Parovichnikova E. N. , Troitskaya V. V. , Gaponova T. V. , Savchenko V. G. 
Published: May 2021

Introduction. The SARS-CoV-2 infection (COronaVIrus Disease 2019, COVID-19) usually progresses uncomplicated in an acute respiratory form but causes frequent severe illness in oncohaematological patients.Aim — analysis of the management and efficacy of medical aid at a haematology clinic during the COVID-19 pandemic.Patients. The clinic admitted 2,130 patients in April 20 — November 20, 2020, with 920 of them triaged into observatory wards. At the time of admission, 907 (98.5 %) patients were SARS-CoV-2 RNA-negative, with 13 hospitalised without nasopharyngeal swab tests. Patient nosology: 235 (25.5 %) lymphoma, 152 (16.5 %) multiple myeloma, 131 (14.2 %) acute leucaemia, 86 (9.3 %) haemophilia, 35 (4 %) Gaucher’s disease, 17 (1.8 %) Waldenstrom macroglobulinemia, 16 (1.7 %) aplastic anaemia, 153 (16.6 %) various surgical diseases, 81 (8.8 %) other haematological diseases and 14 (1.6 %) were bone marrow donors.Results. Among the 920 patients admitted to the observatory, 139 (15 %) were severe and 653 (71 %) had a moderate condition. Fever was reported in 124 (13.5 %) patients at admission. Chest computed tomography (CT) was performed in 809 patients, with recent lung inflammation detected in 121 (15 %) cases. Twenty four (2.6 %) patients were revealed SARS-CoV-2-positive, with 20 diagnoses PCR-verified and four — in chest CT. Ten patients were diagnosed positive in routine examination or at a specialty unit as fever aggravated. Thus, a two-staged SARS-CoV-2 screening with PCR and chest CT allowed an extra 2.6 % detection of COVID-19 cases despite negative tests at admission.Conclusion. The observatory management has reduced the likelihood of nosocomial COVID-19 and ensured a continued supply of specialty medical aid.