bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grass Carp Reproduction in Small Tributaries of Harry S. Truman Reservoir, Missouri: Implications for Establishment in Novel Habitats
Authors: Hayer Cari-Ann , Bayless Michael A. , Richter Catherine A. , George Amy E. , Chapman Duane C. 
Published: July 2021

Abstract
Substantial work has been conducted to estimate the river length required for recruitment of invasive Grass Carp Ctenopharyngodon idella and bigheaded carps (Bighead Carp Hypophthalmichthys nobilis and Silver Carp H. molitrix); however, the distance upstream and size of stream required for spawning remain unclear. Adult Grass Carp are regularly captured in Harry S. Truman Reservoir, Missouri, although there have been only unconfirmed sightings of Silver Carp. Fertile diploid Grass Carp are used legally for vegetation control in Missouri; however, it is uncertain whether Grass Carp in Harry S. Truman Reservoir are the result of natural reproduction or escapees. We used ichthyoplankton tows and environmental DNA (eDNA) to investigate which carp species were present in the reservoir basin and to determine whether these carps were spawning in reservoir tributaries. Grass Carp eggs were collected in four of five tributaries during June 2014. We did not detect eggs, larvae, or eDNA of Bighead Carp or Silver Carp. The occurrence of Grass Carp eggs generally coincided with rapid increases in discharge and turbidity. These tributaries may be the smallest rivers worldwide in which spawning of Grass Carp has been documented. We infer from the developmental stages captured and the distance from the reservoir that sufficient river length exists for egg survival. These results have broad implications concerning the establishment of Grass Carp in other novel habitats, including other reservoirs and lake basins, smaller rivers, and the Laurentian Great Lakes ecosystem.
Broad antiviral and anti‐inflammatory efficacy of nafamostat against SARS‐CoV‐2 and seasonal coronaviruses in primary human bronchiolar epithelia
Authors: Niemeyer Brian F. , Miller Caitlin M. , Ledesma‐Feliciano Carmen , Morrison James H. , Jimenez‐Valdes Rocio , Clifton Clarissa , Poeschla Eric M. , Benam Kambez H. 
Published: July 2021

AbstractAntiviral strategies that target host systems needed for SARS‐CoV‐2 replication and pathogenesis may have therapeutic potential and help mitigate resistance development. Here, we evaluate nafamostat mesylate, a potent broad‐spectrum serine protease inhibitor that blocks host protease activation of the viral spike protein. SARS‐CoV‐2 is used to infect human polarized mucociliated primary bronchiolar epithelia reconstituted with cells derived from healthy donors, smokers and subjects with chronic obstructive pulmonary disease. Nafamostat markedly inhibits apical shedding of SARS‐CoV‐2 from all donors (log10 reduction). We also observe, for the first‐time, anti‐inflammatory effects of nafamostat on airway epithelia independent of its antiviral effects, suggesting a dual therapeutic advantage in the treatment of COVID‐19. Nafamostat also exhibits antiviral properties against the seasonal human coronaviruses 229E and NL6. These findings suggest therapeutic promise for nafamostat in treating SARS‐CoV‐2 and other human coronaviruses.
Sugarcane bagasse fibers at high contents in thermoplastic composites: A novel approach using agro‐industrial residue via thermokinetic mixing
Authors: Lazarini Rafael Gouveia , Marconcini José Manoel 
Published: July 2021

AbstractAgro‐industrial residue from sugarcane cultivation in Brazil generates more than 200 million tons of bagasse per year, which is rich in plant fibers that can be potentially applied in polymer composites. New processing routes are required to process composites with fiber contents above 50% wt. The objective of this work was to incorporate sugarcane bagasse fibers to polypropylene at high contents (50%–80% wt) in the development of composites via thermokinetic mixture. Composites with 50% and 60% fibers showed a traditional composite morphology, while those with 70% and 80% resembled agglomerated composites. The water absorption varied between 5% and 34%, increasing with fiber content, while the bulk density remained relatively constant, close to 1 g/cm3. The flexural strength and the flexural modulus reached 31 MPa and 2.4 GPa, respectively, tending to decrease with fiber content. In summary, the present work showed the viability of the proposed processing route, with only two starting materials, to produce cheap, relatively lightweight composites with mechanical properties close to and water absorption much lower than wood composites (medium‐density fiberboard and medium‐density particleboard) used in similar applications, such as furniture, construction, and automobile industry.
Production of carbon monoxide from a He/CO2 plasma jet as a new strategy for therapeutic applications
Authors: Douat Claire , Escot Bocanegra Pablo , Dozias Sébastien , Robert Éric , Motterlini Roberto 
Published: July 2021

AbstractA new method to deliver carbon monoxide (CO) for medical applications is presented using a kHz‐driven helium plasma jet with a 1% CO2 admixture. Despite being known for its anti‐inflammatory, vasorelaxing, and anti‐apoptotic effects, a possible role of CO generated from plasma for the treatment of various diseases has so far been neglected. Here, we show that CO production of a plasma jet can be tuned from 100 to 2000 ppm. The number of CO molecules produced per pulse is in the range of 1 × 1012 to 1.5 × 1013. To assess the delivery of CO, mouse blood hemoglobin was used as a scavenger of CO and the consequent formation of carboxyhemoglobin was quantified. This study reveals for the first time that plasma can generate and deliver CO for therapeutic interventions.
Heat treatment of thioredoxin fusions increases the purity of α‐helical transmembrane protein constructs
Authors: Schenkel Mathias , Treff Antoine , Deber Charles M. , Krainer Georg , Schlierf Michael 
Published: July 2021

AbstractMembrane proteins play key roles in cellular signaling and transport, represent the majority of drug targets, and are implicated in many diseases. Their relevance renders them important subjects for structural, biophysical, and functional investigations. However, obtaining membrane proteins in high purities is often challenging with conventional purification steps alone. To address this issue, we present here an approach to increase the purity of α‐helical transmembrane proteins. Our approach exploits the Thioredoxin (Trx) tag system, which is able to confer some of its favorable properties, such as high solubility and thermostability, to its fusion partners. Using Trx fusions of transmembrane helical hairpin constructs derived from the human cystic fibrosis transmembrane conductance regulator (CFTR) and a bacterial ATP synthase, we establish conditions for the successful implementation of the selective heat treatment procedure to increase sample purity. We further examine systematically its efficacy with respect to different incubation times and temperatures using quantitative gel electrophoresis. We find that minute‐timescale heat treatment of Trx‐tagged fusion constructs with temperatures ranging from 50 to 90°C increases the purity of the membrane protein samples from ~60 to 98% even after affinity purification. We show that this single‐step approach is even applicable in cases where regular selective heat purification from crude extracts, as reported for Trx fusions to soluble proteins, fails. Overall, our approach is easy to integrate into existing purification strategies and provides a facile route for increasing the purity of membrane protein constructs after purification by standard chromatography approaches.
Molecular frame dipole moment of diatomic molecules within relativistic coupled‐cluster framework: A comparative study of expectation value versus energy derivative approach
Authors: Haldar Soumi , Talukdar Kaushik , Nayak Malaya K. , Pal Sourav 
Published: July 2021

AbstractThe ground state molecular frame dipole moments of alkaline earth metal monofluorides and Group ІІB‐monohydrides have been computed using two analytic methods, namely the Z‐vector technique and the linear expectation value method within the four‐component relativistic coupled cluster singles and doubles framework. We have compared our results with the experimentally measured permanent dipole moments wherever available. It is found that the Z‐vector method, which is an energy‐derivative approach predicts the molecular permanent dipole moment more accurately than the linear expectation value approach in DZ and TZ quality basis set. Further, our study shows that the high‐energy virtual spinors seem to have almost no influence on the permanent dipole moment whereas the core electron correlation slightly affects this molecular property.
Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India
Authors: Maturu Venkata Nagarjuna , Meshram Priti , Das Soumya , Rajput Ashok Kumar , Kotaru Arun Chowdary , Kotak Bhavesh , Markandeywar Neeraj , Chhatwal Simran 
Published: July 2021

AbstractSevere asthma can be associated with eosinophilic or allergic phenotypes or both. Eosinophilic inflammation is associated with exacerbations and disease severity due to biological activity of interleukin‐5 (IL‐5). Patients with severe asthma have reported reduced lung function and poor health‐related quality of life (HRQoL) and may require systemic corticosteroids for its management. Thus, treatment targeting IL‐5 can help improve quality of life and reduce the use of systemic corticosteroids in severe asthma. Mepolizumab is approved for treating severe eosinophilic asthma as it helps reduce exacerbations, improve lung function and asthma control, and reduce the use of systemic glucocorticoids. This further helps in enhancing HRQoL of these patients. This case series includes four adult patients suffering from severe eosinophilic asthma who were treated with mepolizumab.
Discretized quasi‐time‐dependent control for asynchronously switched systems with dynamic dwell‐time
Authors: Tong Yanhui , Shi Peng , Wang Yueying , Huang Bixuan 
Published: July 2021

AbstractConsidering that actuator delay is inevitable and a discretized control design method is more preferable in practice, this article is concerned with the discretized quasi‐time‐dependent (QTD)control for continuous‐time asynchronously switched systems via dynamic output‐feedback. The persistent dwell‐time (PDT) is employed to analyze the stability and‐gain for switched systems in the framework of multiple QTD Lyapunov function approach, and the concept of dynamic dwell‐time (DDT) is used to characterize a category of switching signals for asynchronously switched systems with measurable switching lag, which means that the controlled plant can adjust its dwell‐time on some mode dynamically according to the switching lag of the corresponding controller. First, the stability and‐gain are analyzed for switched systems with PDT. Then, by constructing controller‐dependent multiple QTD Lyapunov functions, a QTD control synthesis condition is derived based on the obtained stability criterion. The developed controller can guarantee the closed‐loop stability andperformance for the underlying system under a class of identified DDT switching signals. Subsequently, a discretized QTD control scheme is proposed by choosing the discretized quadratic version of the constructed Lyapunov functions. The synthesis condition is formulated as a set of finite‐dimensional LMIs, and hence it can be easily tractable. Finally, the proposed control scheme is applied to the tracking control of a mobile robot to illustrate its effectiveness and application potential.
The importance of sustainability engagement in small businesses supplier collaboration
Authors: Ukko Juhani , Saunila Minna , Nasiri Mina , Rantala Tero 
Published: July 2021

AbstractSustainability engagement is suggested to increase future company value. Collaboration between companies can assist them to become more sustainable. Even though collaboration can be seen as instrumental in developing more sustainable companies, the rise of e‐business has changed the game in terms of attaining high performance. Thus, this study investigates the relations among supplier collaboration, sustainability, and market performance in the context of e‐business. Specifically, the aim of this study is to determine how supplier collaboration leads small e‐businesses to develop e‐business sustainability and, in turn, deliver enhanced market performance. The data were collected with a cross‐sectional random sampling of small online store operators in Finland. Supplier collaboration was found to influence market performance via e‐business sustainability. The results offer implications for firms operating in e‐business by supporting collaboration with suppliers and sustainability values while maintaining high market performance.
T-Cell Pseudolymphoma Secondary to Ixazomib for Multiple Myeloma
Authors: Haq M. , Reyal Y. , Tiffin N. , Szakacs S. , Ferguson L. 
Published: July 2021

Abstract
We present a case of a 54-year-old male with multiple myeloma (MM) who presented with widespread pruritic erythematous lesions following ixazomib treatment. This occurred after his third cycle of treatment with ixazomib, thalidomide and dexamethasone and was controlled by potent steroids and temporary cessation of ixazomib. The strong correlation between the timeline of the rash, ixazomib treatment and subsequent cessation led to a diagnosis of a drug-induced rash. Skin biopsy histology, immunochemistry and the absence of monoclonal T-cell receptor gene rearrangement further confirmed the diagnosis of a T-cell pseudolymphoma secondary to ixazomib. Ixazomib is an oral proteasome inhibitor used in the treatment of MM. Other proteasome inhibitors have been reported to trigger cutaneous adverse effects. However, to our knowledge, this is the first report of pseudolymphoma following proteasome inhibitor use. Dermatologists should be aware of this potential effect and the possible management pathways such as cessation and dose reduction.
Early‐age behavior and mechanical properties of cement‐based materials with various types and fineness of recycled powder
Authors: Wu Huixia , Liang Chaofeng , Xiao Jianzhuang , Xu Jianguang , Ma Zhiming 
Published: July 2021

AbstractRecycled powder (RP) that includes recycled paste powder (RPP), recycled mortar powder (RMP), and recycled concrete powder (RCP) is an eco‐friendly alternative binder. This work investigated the influence of RP types and fineness on early‐age behavior and mechanical strength of cement‐based materials. The results show that substituting RP for cement causes the reduction of new hydration products in cement‐based materials. The blended RP decreases the fluidity of paste mixture, and the fluidity of paste including fine RPP is lower than that of paste including fine RMP and RCP; moreover, the fluidity increases following the growth of RP particle size. Incorporating fine RPP shortens the setting time of cement‐based materials, while the setting time is prolonged as RMP and RCP incorporate; in addition, the enlarged particle size of RP prolongs the setting time. The drying shrinkage increases following the increasing replacement ratio of RPP. Incorporating less proportion of fine RMP and RCP lessens the drying shrinkage of paste, while the drying shrinkage increases after coarse or high‐volume RMP and RCP substituting. The maximum shrinkage of paste including 30% fine and coarse RCP is 3.4% and 7.3% higher than that of plain paste. Substituting fine RP for less dosage of cement has less impact on the mechanical strength of its newmade mortar, while the mechanical strength markedly decreases after high‐volume or coarse RP substituting. The compression strength of mortar including 30% fine and coarse RCP is 22.2% and 35.1% lower than that of plain mortar.
Proinflammatory response caused by lead nanoparticles triggered by engulfed nanoparticles
Authors: Shimizu Kaori , Horie Masanori , Tabei Yosuke , Kashiwada Shosaku 
Published: July 2021

AbstractIn this study, the cellular effects of lead (Pb) nanoparticles with a primary particle size of 80 nm were evaluated in two types of cell lines: human lung carcinoma A549 and macrophage‐differentiated THP‐1 cells (dTHP‐1). The cellular responses induced by the Pb nanoparticles varied among the cell types. Exposure to Pb nanoparticles for 24 h at a concentration of 100 μg/ml induced interleukin‐8 (IL‐8) expression in dTHP‐1 cells. Induction of IL‐8 expression in A549 was lower than dTHP‐1 cells. Pb nanoparticles also induced the gene expression of heme oxygenase‐1 in dTHP‐1 cells but not in A549 cells. Though cellular uptake of Pb nanoparticles was observed in both the cell types, the amount of internalized Pb particles was lower in A549 cells than that in dTHP‐1 cells. Gene expression of metallothionein 2A was remarkably enhanced by Pb nanoparticle exposure in dTHP‐1 cells. Compared with Pb nanoparticles, induction of cytokines caused by lead nitrate (Pb[NO3]2), a water‐soluble Pb compound, was smaller. In conclusion, the present study revealed that Pb nanoparticles induced a stronger cellular response than Pb(NO3)2, primarily by eliciting cytokine production, in a cell type‐dependent manner.
Relative Calabi–Yau structures II: shifted Lagrangians in the moduli of objects
Authors: Brav Christopher , Dyckerhoff Tobias 
Published: July 2021

AbstractWe show that a Calabi–Yau structure of dimension d on a smooth dg category $${C}$$
C
induces a symplectic form of degree $$2-d$$

2
-
d

on ‘the moduli space of objects’ $${{\mathcal {M}}}_{{C}}$$

M
C

. We show moreover that a relative Calabi–Yau structure on a dg functor $${C}\rightarrow { D}$$

C
→
D

compatible with the absolute Calabi–Yau structure on C induces a Lagrangian structure on the corresponding map of moduli $${{\mathcal {M}}}_{{ D}} \rightarrow {{\mathcal {M}}}_{{C}}$$

M
D

→

M
C

.
Mundhöhlen- und Pharynxkarzinome: Inzidenz, Mortalität und Überleben in Deutschland
Authors: Jansen Lina , Moratin Julius , Waldmann Annika , Zaoui Karim , Holleczek Bernd , Nennecke Alice , Pritzkuleit Ron , Plinkert Peter K. , Hoffmann Jürgen , Arndt Volker 
Published: July 2021

ZusammenfassungHintergrundDie Gruppe der Lippen‑, Mundhöhlen- und Pharynxkarzinome (ICD-10: C00–C14) beschreibt eine heterogene Gruppe bösartiger Tumoren, deren Inzidenz, Mortalität und Überleben sich nach Entität stark unterscheiden.Ziel der ArbeitDiese Arbeit gibt eine detaillierte Übersicht epidemiologischer Maßzahlen für diese Tumorentitäten unter Berücksichtigung der Heterogenität bezüglich Alter, Geschlecht, Lokalisation und Stadium.Material und MethodenInzidenz- und Mortalitätsdaten für Deutschland für die Jahre 1999–2016 wurden aus der interaktiven Datenbank des Zentrums für Krebsregisterdaten (ZfKD) extrahiert. Alters- und Stadienverteilungen und altersstandardisiertes relatives 5‑Jahres-Überleben wurden auf dem gepoolten ZfKD-Datensatz (Diagnosejahre 1999–2017) berechnet.ErgebnisseIm Jahr 2016 lagen die Inzidenz und Mortalität für alle Entitäten insgesamt bei 17,6 bzw. 7,0 pro 100.000 Männern und 6,5 bzw. 1,8 pro 100.000 Frauen. Das relative 5‑Jahres-Überleben für 2015–2017 lag bei 53 % bzw. 63 %. Es zeigten sich deutliche Unterschiede in der Überlebensrate und in der Alters- und Stadienverteilung zwischen den Entitäten. Im zeitlichen Verlauf zeigte sich ein Anstieg des Alters bei Diagnose, insbesondere bei Männern, aber keine Veränderung in der Stadienverteilung. Trotzdem stieg das relative 5‑Jahres-Überleben zwischen 1999–2002 und 2013–2017 von 45 % (Männer) bzw. 59 % (Frauen) auf 52 % bzw. 63 %.DiskussionDie starke Heterogenität der untersuchten Tumoren verdeutlicht die Notwendigkeit einer nach Geschlechtern und Lokalisationen getrennten Betrachtung für eine aussagekräftige Interpretation der epidemiologischen Kennzahlen. Mit Ausbau der klinischen Krebsregistrierung werden in Zukunft zusätzliche Analysen unter Einbezug weiterer wichtiger klinischer Faktoren möglich sein.
Detection of ovarian cancer (± neo-adjuvant chemotherapy effects) via ATR-FTIR spectroscopy: comparative analysis of blood and urine biofluids in a large patient cohort
Authors: Giamougiannis Panagiotis , Morais Camilo L. M. , Rodriguez Brice , Wood Nicholas J. , Martin-Hirsch Pierre L. , Martin Francis L. 
Published: July 2021

AbstractOvarian cancer remains the most lethal gynaecological malignancy, as its timely detection at early stages remains elusive. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy of biofluids has been previously applied in pilot studies for ovarian cancer diagnosis, with promising results. Herein, these initial findings were further investigated by application of ATR-FTIR spectroscopy in a large patient cohort. Spectra were obtained by measurements of blood plasma and serum, as well as urine, from 116 patients with ovarian cancer and 307 patients with benign gynaecological conditions. A preliminary chemometric analysis revealed significant spectral differences in ovarian cancer patients without previous chemotherapy (n = 71) and those who had received neo-adjuvant chemotherapy—NACT (n = 45), so these groups were compared separately with benign controls. Classification algorithms with blind predictive model validation demonstrated that serum was the best biofluid, achieving 76% sensitivity and 98% specificity for ovarian cancer detection, whereas urine exhibited poor performance. A drop in sensitivities for the NACT ovarian cancer group in plasma and serum indicates the potential of ATR-FTIR spectroscopy to identify chemotherapy-related spectral changes. Comparisons of regression coefficient plots for identification of biomarkers suggest that glycoproteins (such as CA125) are the main classifiers for ovarian cancer detection and responsible for smaller differences in spectra between NACT patients and benign controls. This study confirms the capacity of biofluids’ ATR-FTIR spectroscopy (mainly blood serum) to diagnose ovarian cancer with high accuracy and demonstrates its potential in monitoring response to chemotherapy, which is reported for the first time.Graphical abstract
Morphological features of the chiasma tendinum and its relation with surface landmarks and pulleys: a cadaveric study
Authors: Dinç Uğur , Şengezer Ecem , Beger Orhan , Yılmaz Merve Şehide , Kurtoğlu Olgunus Zeliha 
Published: July 2021

Abstract
Aim
Chiasma tendinum (Camper’s chiasm) is of great importance in the delicate movements and stability of the fingers and takes place poorly in the literature. This study aims to reveal the morphometric details of the chiasma tendinum in relation with pulleys and other relevant structures.

Materials and methods
Palm and 2nd to 5th fingers of 10 (6 male, 4 female) formalin fixed cadavers were used bilaterally. After determining the superficial reference points on the fingers, the skin and the tendon sheath were incised, and then measurements of chiasma tendinum and related tendons were performed. The measurements were analyzed with respect to fingers, genders, and sides. Finally, the types of chiasma tendinum were identified and then grouped as symmetrical, asymmetrical, and pseudo chiasm.

Results
Pulley and chiasma tendinum positions were correlated with finger length (p < 0.01). Pulley lengths were significantly less in females. Asymmetrical chiasma tendinum types were found in 45% of the fingers. In most comparisons, values for fifth finger were significantly different than that of other fingers and chiasma tendinum types differed according to fingers and gender. The case of no fiber exchange was observed only in the 5th finger in 15%.

Conclusion
Findings related to the prediction of location of the pulleys and chiasma tendinum according to the superficial signs, awareness of cases where one of the two arms of the flexor digitorum superficialis is extremely thin and no fiber exchanges that may be risk factors for spontaneous tendon rupture may help provide more accurate approaches in relevant clinical applications.