bluuebunny/crossref_metadata_2025_split huggingface dataset:
A look at soft neutrosophic spaces
Authors: Mehmood Arif , Al Ghour Samer , Ishfaq Muhammad , Afzal Farkhanda 
Published: October 2021

In this article, new definition of neutrosophic soft ** b-open set is introduced with the help of neutrosophic soft α-open set and neutrosophic soft β-open set. With the application of this new definition some neutrosophic soft separation axioms and neutrosophic soft other separation axioms are addressed with respect to soft points of the spaces. Suitable examples are provided for the clarification of different results. Soft countability results and its engagements with different other neutrosophic soft results are studied. In continuation, characterization of Bolzano Weirstrass Property with respect to neutrosophic soft results and neutrosophic soft compactness results are inaugurated.
Computing crisp simulations for fuzzy labeled transition systems
Authors: Nguyen Linh Anh 
Published: October 2021

The problem of checking whether a state in a finite fuzzy labeled transition system (FLTS) crisply simulates another is one of the fundamental problems of the theory of FLTSs. This problem is of the same nature as computing the largest crisp simulation between two finite FLTSs. A naive approach to the latter problem is to crisp the given FLTSs and then apply one of the currently known best methods to the obtained crisp labeled transition systems. The complexity of the resulting algorithms is of order O (l (m + n) n), where l is the number of fuzzy values occurring in the specification of the input FLTSs, m is the number of transitions and n is the number of states of the input FLTSs. In the worst case, l can be m + n and O (l (m + n) n) is the same as O ((m + n) 2n). In this article, we design an efficient algorithm with the complexity O ((m + n) n) for computing the largest crisp simulation between two finite FLTSs. This gives a significant improvement. We also adapt our algorithm to computing the largest crisp simulation between two finite fuzzy automata.
Dyslipidemia in Apparently Healthy Population of Dera Ismail Khan, Khyber Pakhtunkhwa Province, Pakistan
Authors: Muhammad Nawshad , Ullah Shamsher , Safi Sher Zaman 
Published: October 2021

Dyslipidemia and its high prevalence in patients of hypertension and other non-communicable diseases is increasing. The aim of current study was to highlight the dyslipidemia in apparently healthy population by lipid profiling in Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan. 150 individuals apparently healthy and with no previous records of hyperlipidemia were recruited. Blood plasma samples were collected aseptically from healthy individuals for determination of lipid profile. Blood plasma samples were collected aseptically. Total cholesterol (TC) levels High density lipoprotein cholesterol (HDL-C) levels, Triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) were determined. The 150 healthy subjects were between 20-70 years. Mean plasma levels of TC was 166.4 ±28.45 mg/dl, HDL-C was 48.34 ±8.79 mg/dl, 48.34 ±8.79 mg/dl, LDL-C was 87.42 ±29.82 mg/dl and TG were 151 ±65.92 mg/dl. TC and HDL-C levels were desirable and better. The level of LDL-C level below 100 mg/dl. The triglyceride level was recorded above upper limit. There is a need to investigate the problem of dyslipidemia at the community level. The high TC level in healthy population is an alarming situation and could be used to predict future complications associated with it.
When and How Does Work-family Conflict Turn into Psychological Disorder?
Authors: MITRA GOURANGA , Srivastava Bhartendunath 
Published: October 2021

ABSTRACT
The paper attempts to re-conceptualize work-family conflict based on qualitative contents from online survey of Indian managers. Researchers focus on perceptions of work-family conflict tracing the typology of antecedents and sources, dynamics of feelings aroused, covert adjustments, overt/behavioural manifestations, and the consequences to individuals and organizations. It is contended that covert adjustments (through ego defense mechanisms) in a conflict situation play a pivotal role before giving behavioural expression to feelings aroused. Further it is contributed to work-family conflict using 2(positive/negative)x2 (directed toward self/others)x3(location; workplace/family/both) model together with the adverse effects of psychological deviance. The researchers add value to the existing literature on conflict management by extending the role of psychological dynamics of affective arousal, covert adjustments and overt manifestations of conflict, and progression of the conflict experience into psychological distress possibly leading to adverse effects of psychological deviance requiring psychiatric or psychological help.
Deteksi Telur Nematoda Gastrointestinal Pada Feses Kuda (Equus caballus) Cidomo Di Pasar Kecamatan Empang Sumbawa
Authors: Pratama Iwan Husni , Supriadi Supriadi , Janah Maratun , Agustin Alfiana Laili Dwi 
Published: October 2021

Cacing nematoda adalah salah satu kelompok cacing yang berdistribusi luas pada kuda cidomo. Dampak infeksi cacing nematoda pada kuda diantaranya dapat menyebabkan anemia, nafsu makan menurun, kuda mengalami penurunan berat badan secara derastis, serta akan terlihat kusam dan rambut rontok. Berbagai jenis cacing nematoda pada kuda juga dapat bersifat zoonosis. Tujuan penelitian ini Untuk mempelajari ada tidaknya telur cacing nematoda pada Feses kuda cidomo di pasar Kecematan Empang. Sebanyak 16 sampel telah dikoleksi dari kuda cidomo Dengan metode acak. Seluruh sampel kemudian dibawa kelaboratorium kemudian di periksa menggunakan metode natif dan pengapungan. Hasil pemeriksaan sampel menunjukkan ada 10 sampel positif mengandung telur cacing Nematoda. Berdasarkan hasil pemeriksaan terhadap telur yang ditemukan cacing nematoda yang ditemukan adalah: Strongylus spp. Trichostrongylus spp, Oesophagostomum spp, Cyathostoma spp.
Perbandingan Waktu Post Thawing Motility (PTM) Semen Beku Sapi Bali Terhadap Media Air Dengan Suhu 37ºC
Authors: Syamlan Ahmad , Janah Maratun , Atma Candra Dwi , Tirtasari Kunti 
Published: October 2021

Thawing merupakan pencairan kembali semen yang telah dibekukan sebelum dilakukan Inseminasi Buatan (IB), Suhu dan Lama thawing mempunyai pengaruh besar terhadap keadaan spermatozoa khususnya keutuhan spermatozoa sehingga tetap memiliki kemampuan membuahi ovum yang tinggi. Oleh karena itu, untuk mendpatkan kualitas spermatozoa semen beku sapi Bali yang memenuhi kritaria dalam pelaksanaan IB dibutuhkan kombinasi suhu dan lama thawing yang baik. Tujuan penelitian ini adalah untuk mengetahui suhu dan waktu lama thawing semen beku sapi Bali yang optimal untuk digunakan dalam IB. penelitian dilakukan mulai tanggal 8 Maret 2021 sampai dengan 10 Maret 2021. Materi yang digunakan dalam penelitian ini adalah semen beku dari sapi Bali dari Balai Inseminasi Buatan Daerah (BBID) Banyumulek. Metode penelitian yang digunakan adalah metode eksperimental dengan 4 perlakuan yaitu suhu 37ºC dan lama thawing 30 menit, 60 menit, 90 menit dan 120 menit. Tiap perlakuan diuang sebanyak 3 kali. Variabel yang diamati dalam penelitian ini adalah motilitas dan viailitas spermatozoa. Motilitas diamati dengan metode mikroskop sedangkan viabilitas diamati dengan pewarnaan eosin-negrosin. Data hasil penelitian dianalisis dengan menggunakan ANOVA. Hasil penelitian menunjukkan bahwa suhu dan waktu lama thawing berpengaruh terhadap kualitas spermatozoa semen beku sapi Bali. Pada motilitas spermatozoa dengan suhu 37ºC dengan waktu lama thawing 120 menit sangat kurang optimal untuk digunakan saat IB, Persentase viablitas spermatozoa pada suhu 37ºC dengan waktu lama thawing 30 menit, 60 menit dan 90 menit masih layak digunakan untuk digunakan dalam IB, karena pada suhu dan lama thawing tersebut, menunjukkan hasil 50% keatas.
Synthesis, 3D-QSAR and Molecular Docking Study of Nopol-Based 1,2,4-Triazole-Thioether Compounds as Potential Antifungal Agents
Authors: Wang Xiu , Duan Wengui , Lin Guishan , Li Baoyu , Chen Ming , Lei Fuhou 
Published: October 2021

Cytochrome bc1 complex is an important component of cellular respiratory chain, and it is also an important target enzyme to inhibit the growth of plant pathogens. Using cytochrome bc1 complex as the target enzyme, twenty-three novel nopol-based 1,2,4-triazole-thioether compounds were designed and synthesized from natural preponderant resource β-pinene, and their structures were confirmed by FT-IR, NMR, ESI-MS and elemental analysis. The in vitro antifungal activity of the target compounds 5a-5w was preliminarily evaluated against eight plant pathogens at the concentration of 50 µg/ml. The bioassay results showed that the target compounds exhibited the best antifungal activity against Physalospora piricola, in which compounds 5b (R= o-CH3 Ph), 5e (R= o-OCH3 Ph), 5h (R= o-F Ph), 5m (R= o-Br Ph), 5o (R= m,m-OCH3 Ph), and 5r (R= p-OH Ph) had inhibition rates of 91.4, 83.3, 86.7, 83.8, 91.4 and 87.3%, respectively, much better than that of the positive control chlorothalonil. Also, compound 5a (R= Ph) had inhibition rate of 87.9% against Rhizoeotnia solani, and compound 5b (R= o-CH3 Ph) had inhibition rates of 87.6 and 89% against Bipolaris maydis and Colleterichum orbicala, respectively. In order to develop novel and promising antifungal compounds against P. piricola, the analysis of three-dimensional quantitative structure-activity relationship (3D-QSAR) was carried out using the CoMFA method on the basis of their antifungal activity data, and a reasonable and effective 3D-QSAR model (r2 = 0.944, q2 = 0.685) has been established. In addition, the theoretical study of molecular docking revealed that the target compounds could bind to and interact with the site of cytochrome bc1 complex.
Brown Adipose Tissue Activation Is Involved in Atherosclerosis of ApoE−/− Mice Induced by Chronic Intermittent Hypoxia
Authors: Wang Yue , Jiang Hong-feng , Liu Bei-bei , Chen Lei-lei , Wang Yue , Liu Xin-yan , Suo Min , Wu Xiao-fan 
Published: October 2021

Background: Obstructive sleep apnea is an atherogenesis factor of which chronic intermittent hypoxia is a prominent feature. Chronic intermittent hypoxia (CIH) exposure can sufficiently activate the sympathetic system, which acts on the β3 adrenergic receptors of brown adipose tissue (BAT). However, the activity of BAT and its function in CIH-induced atherosclerosis have not been fully elucidated.Methods: This study involved ApoE−/− mice which were fed with a high-fat diet for 12 weeks and grouped into control and CIH group. During the last 8 weeks, mice in the CIH group were housed in cages to deliver CIH (12 h per day, cyclic inspiratory oxygen fraction 5–20.9%, 180 s cycle). Atherosclerotic plaques were evaluated by Oil Red O, hematoxylin and eosin, Masson staining, and immunohistochemistry. Afterward, we conducted immunohistochemistry, western blotting, and qRT-PCR of uncoupling protein 1 (UCP1) to investigate the activation of BAT. The level of serum total cholesterol (TC), triglyceride, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and free fatty acid (FFA) were measured. Finally, RNA-Sequencing was deployed to explore the differentially expressed genes (DEGs) and their enriched pathways between control and CIH groups.Results: Chronic intermittent hypoxia exposure promoted atherosclerotic plaque area with increasing CD68, α-SMA, and collagen in plaques. BAT activation was presented during CIH exposure with UCP1 up-regulated. Serum TC, triglyceride, LDL-c, and FFA were increased accompanied by BAT activation. HDL-c was decreased. Mechanistically, 43 lipolysis and lipid metabolism-associated mRNA showed different expression profiling between the groups. Calcium, MAPK, and adrenergic signaling pathway included the most gene number among the significantly enriched pathways.Conclusion: This study first demonstrated that BAT activation is involved in the progression of CIH-induced atherosclerosis, possibly by stimulating lipolysis.
Association of Subregional Quantitative Ultra-widefield Fluorescence Angiography Characteristics With the Occurrence of Diabetic Macular Edema and Proliferative Diabetic Retinopathy
Authors: Sun Gongpeng , Wang Xiaoling , Jiang Jingwen , Yi Zuohuizi , Fu Mei , Yang Xueying , Zheng Hongmei , Chen Changzheng 
Published: October 2021

Purpose: To explore the relationships of region-specific properties of ultra-widefield fluorescence angiography (UWFFA) images with two adverse outcomes, diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR), and also the severity of diabetic retinopathy (DR).Methods: A cross-sectional observational study was performed to retrospectively analyze UWFFA images of patients with DR. All patients underwent UWFFA and optical coherence tomography examination. Leakage index and microaneurysm (MA) count were measured using Trainable Weka Segmentation, a machine learning algorithm, and ischemic index (ISI) was measured manually. The correlation between UWFFA parameters and severity of DR was analyzed, and receiver operating characteristic curves were used to estimate their diagnostic value for DME and PDR.Results: A total of 108 eyes from 108 patients with DR (mean age of 56.04 ± 8.85 years) were analyzed. As the severity of DR increased, the ISI and leakage index of the panretina and all subregions increased. Panretinal MA count and leakage index were significantly higher in eyes with DME than those without DME (p = 0.044 and 0.001, respectively). Leakage index and ISI were significantly higher in eyes with PDR than those without PDR in both panretinal and subregion-specific measurements (all p &lt; 0.05). Throughout the retina and specifically in the posterior area (PoA), the leakage index had a higher diagnostic value for DME than ISI or MA count (all p &lt; 0.05). The diagnostic value of MA count for PDR was lower than that of ISI and leakage index (all p &lt; 0.05).Conclusion: The ISI, leakage index, and MA count in the PoA and panretina correlated with the severity of DR, especially the posterior parameter. The leakage index was more valuable than ISI and MA count in determining the occurrence of DME. ISI and leakage index were better predictors of PDR.
Ultrasound Assessment of Diaphragm Thickness and Thickening: Reference Values and Limits of Normality When in a Seated Position
Authors: Boussuges Alain , Rives Sarah , Finance Julie , Chaumet Guillaume , Vallée Nicolas , Risso Jean-Jacques , Brégeon Fabienne 
Published: October 2021

Background: Diagnosing diaphragm dysfunction in the absence of complete paralysis remains difficult. The aim of the present study was to assess the normal values of the thickness and the inspiratory thickening of both hemidiaphragms as measured by ultrasonography in healthy volunteers while in a seated position.Methods: Healthy volunteers with a normal pulmonary function test were recruited. The diaphragmatic thickness was measured on both sides at the zone of apposition of the diaphragm to the rib cage during quiet breathing at end-expiration, end-inspiration, and after maximal inspiration. The thickening ratio, the thickening fraction, and the thickness at end-inspiration divided by the thickness at deep breathing were determined. The mean values and the lower and upper limits of normal were determined for men and women.Results: 200 healthy volunteers (100 men and 100 women) were included in the study. The statistical analysis revealed that women had a thinner hemidiaphragm than men on both sides and at the various breathing times studied. The lower limit of normality of the diaphragm thickness measured at end-expiration was estimated to be 1.3 mm in men and 1.1 mm in women, on both sides. The thickening fraction did not differ significantly between men and women. In men, it ranged from 60 to 260% on the left side and from 57 to 200% on the right side. In women, it ranged from 58 to 264% on the left side and from 60 to 229% on the right side. The lower limits of normality of the thickening fraction were determined to be 40 and 39% in men and 39 and 48% in women for the right and left hemidiaphragms, respectively. The upper limit for normal of the mean of both sides of the ratio thickness at end-inspiration divided by the thickness at deep breathing was determined to be 0.78 in women and 0.79 in men.Conclusion: The normal values of thickness and the indexes of diaphragmatic function should help clinicians with detecting diaphragm atrophy and dysfunction.
Development and Validation of Nomogram to Preoperatively Predict Intraoperative Cerebrospinal Fluid Leakage in Endoscopic Pituitary Surgery: A Retrospective Cohort Study
Authors: Cai Xiangming , Zhu Junhao , Yang Jin , Tang Chao , Yuan Feng , Cong Zixiang , Ma Chiyuan 
Published: October 2021

BackgroundPituitary adenomas (PAs) are the most common tumor of the sellar region. PA resection is the preferred treatment for patients with clear indications for surgery. Intraoperative cerebrospinal fluid (iCSF) leakage is a major complication of PA resection surgery. Risk factors for iCSF leakage have been studied previously, but a predictive nomogram has not yet been developed. We constructed a nomogram for preoperative prediction of iCSF leakage in endoscopic pituitary surgery.MethodsA total of 232 patients who underwent endoscopic PA resection at the Department of Neurosurgery in Jinling Hospital between January of 2018 and October of 2020 were enrolled in this retrospective study. Patients treated by a board-certified neurosurgeon were randomly classified into a training cohort or a validation cohort 1. Patients treated by other qualified neurosurgeons were included in validation cohort 2. A range of demographic, clinical, radiological, and laboratory data were acquired from the medical records. The Least Absolute Shrinkage and Selection Operator (LASSO) algorithm and uni- and multivariate logistic regression were utilized to analyze these features and develop a nomogram model. We used a receiver operating characteristic (ROC) curve and calibration curve to evaluate the predictive performance of the nomogram model.ResultsVariables were comparable between the training cohort and validation cohort 1. Tumor height and albumin were included in the final prediction model. The area under the curve (AUC) of the nomogram model was 0.733, 0.643, and 0.644 in training, validation 1, and validation 2 cohorts, respectively. The calibration curve showed satisfactory homogeneity between the predicted probability and actual observations. Nomogram performance was stable in the subgroup analysis.ConclusionsTumor height and albumin were the independent risk factors for iCSF leakage. The prediction model developed in this study is the first nomogram developed as a practical and effective tool to facilitate the preoperative prediction of iCSF leakage in endoscopic pituitary surgery, thus optimizing treatment decisions.
Family and Developmental History of Individuals With Autism Spectrum Disorder: Importance of the Clinical Diagnostic Interview for Diagnosis in Adolescents. An Explorative Study
Authors: Waltereit Johanna , Czieschnek Charlotte , Albertowski Katja , Roessner Veit , Waltereit Robert 
Published: October 2021

Background: Diagnosis of autism spectrum disorder (ASD) can be made early in childhood, but also later in adolescence or adulthood. In the latter cases, concerns about an individual's behavior typically lead to consultation of a mental health professional (MHP). As part of the initial clinical examination by the MHP, a clinical diagnostic interview is performed, in order to obtain the patient's history, and may lead to the hypothesis of ASD. We were here interested to study family and developmental history as key parts of the patient's history. The aim of the study was to investigate empirical differences between adolescents with ASD and adolescent control persons in family and developmental history.Method: Clinical diagnostic interview items addressing family and developmental history were adopted from their regular use at several university hospitals and in leading textbooks. Parents of male adolescents with normal intelligence and an ASD diagnosis (n = 67) and parents of male adolescents without psychiatric diagnosis (n = 51) between the age of 12 and 17 years were investigated. Data were operationalized into three categories: 0 = normal behavior, 1 = minor pathological behavior, and 2 = major pathological behavior. Differences were analyzed by multiple t-test of two-way ANOVA.Results: Adolescents with ASD expressed a profile of items significantly differing from control persons. Comparison of significant items with the empirical ASD literature indicated robust accordance.Conclusions: Our findings support the importance and feasibility of the clinical diagnostic interview of family and developmental history for initiation of the diagnostic process of ASD in adolescents.
Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm
Authors: Kuznetsov V. A. , Enina T. N. , Soldatova A. M. , Petelina T. I. , Dyachkov S. M. , Salamova L. A. 
Published: October 2021

Purpose. To design a mathematical model, that can predict a positive response to cardiac resynchronization therapy (CRT) in patients with congestive heart failure (CHF) and sinus rhythm, according to complex analysis of neurohumoral and immune activation biomarkers, fibrosis, renal dysfunction, echocardiography.Methods. Parameters of echocardiography, plasma levels of NT-proBNP, interleukins-1β, 6, 10, tumor necrosis factor α, С-reactive protein (СRP), matrix metalloproteinase-9 (ММР-9), tissue inhibitors of metalloproteinase 1 and 4, cystatin С (CYSTATIN) were studied in 40 CHF patients with sinus rhythm (65% coronary artery disease patients, 75% males, mean age 54.8±10.6 years old) during the period of maximum decrease of left ventricular end-systolic volume (LVESV) (mean duration 27.5 [11.1; 46.3] months). Responders (decrease in LVESV ≥15%) and non-responders (decrease in LVESV <15%) were identified.Results. The number of responders was 26 (65%). The initial set of variables included: age, left ventricular ejection fraction (EF), pulmonary artery systolic pressure, right ventricle size and NT-proBNP, СRP, ММР-9, CYSTATIN. According to logistic regression analysis, a prediction model of positive CRT response was created. The specificity of the model was 92.9%, sensitivity - 83.3%, AUC=0.952 (р˂0.001).Conclusion. The proposed model, based on the assessment of left ventricle EF and circulating biomarkers of inflammation, fibrosis, and renal function, strongly suggests a higher possibility of response to CRT.