bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weighted Gene Co-expression Network Analysis Identifies Crucial Genes Mediating Progression of Carotid Plaque
Authors: Chen Mengyin , Chen Siliang , Yang Dan , Zhou Jiawei , Liu Bao , Chen Yuexin , Ye Wei , Zhang Hui , Ji Lei , Zheng Yuehong 
Published: February 2021

BackgroundSurface rupture of carotid plaque can cause severe cerebrovascular disease, including transient ischemic attack and stroke. The aim of this study was to elucidate the molecular mechanism governing carotid plaque progression and to provide candidate treatment targets for carotid atherosclerosis.MethodsThe microarray dataset GSE28829 and the RNA-seq dataset GSE104140, which contain advanced plaque and early plaque samples, were utilized in our analysis. Differentially expressed genes (DEGs) were screened using the “limma” R package. Gene modules for both early and advanced plaques were identified based on co-expression networks constructed by weighted gene co-expression network analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes Genomes (KEGG) analyses were employed in each module. In addition, hub genes for each module were identified. Crucial genes were identified by molecular complex detection (MCODE) based on the DEG co-expression network and were validated by the GSE43292 dataset. Gene set enrichment analysis (GSEA) for crucial genes was performed. Sensitivity analysis was performed to evaluate the robustness of the networks that we constructed.ResultsA total of 436 DEGs were screened, of which 335 were up-regulated and 81 were down-regulated. The pathways related to inflammation and immune response were determined to be concentrated in the black module of the advanced plaques. The hub gene of the black module was ARHGAP18 (Rho GTPase activating protein 18). NCF2 (neutrophil cytosolic factor 2), IQGAP2 (IQ motif containing GTPase activating protein 2) and CD86 (CD86 molecule) had the highest connectivity among the crucial genes. All crucial genes were validated successfully, and sensitivity analysis demonstrated that our results were reliable.ConclusionTo the best of our knowledge, this study is the first to combine DEGs and WGCNA to establish a DEG co-expression network in carotid plaques, and it proposes potential therapeutic targets for carotid atherosclerosis.
Adapting Summer Education Programs for Navajo Students: Resilient Teamwork
Authors: Kahn Carmella B. , Dreifuss Heather , Teufel-Shone Nicolette I. , Tutt Marissa , McCue Kelly , Wilson Jamie , Waters Amber-Rose , Belin Kalvina L. , Bauer Mark C. 
Published: February 2021

In May 2020, the Navajo Native American Research Center for Health Partnership (Navajo NARCH) was scheduled to launch two summer programs: a 10 weeks-long Summer Research Enhancement Program (SREP) for undergraduate students to learn and practice health research methods and participate in a practicum experience, and a week-long Indigenous Summer Enhancement Program (ISEP) for high school students that introduces a range of health professions and develops leadership qualities. Students accepted into the programs are predominantly Navajo and live within Navajo Nation (NN) during the summer. Due to NN restrictions and CDC guidelines for physically distancing in response to the coronavirus (COVID-19) pandemic, the Navajo NARCH team organized to offer both programs entirely online via Zoom™. This paper explores the instructional teams’ adaptation process to maintain a commitment to preserve the programs’ supportive environment for exploring and developing strong multicultural approaches in public health and health research. In preparation for online instruction, the team developed and offered workshops for staff and instructors to address anticipated challenges. The team identified the following challenges: technological difficulties, social disconnectedness, consistent student engagement, and facilitation of a practicum research experience. Results showed that program adaptations were successful as the team applied collaborative and holistic approaches, and established social connections remotely with students to offer meaningful research and practicum experiences.
O filósofo dentro e fora do ordinário: Hume, Stanley Cavell e a instabilidade das conclusões céticas
Authors: Cachel Andrea 
Published: February 2021

O objetivo deste artigo é discutir o que representa a instabilidade das reflexões filosóficas, segundo a leitura que dela faz a filosofia de Stanley Cavell, em diálogo com Hume, filósofo que teria abordado esse problema em sua maior amplitude. Nesse sentido, em primeiro lugar o texto apresenta as linhas gerais da análise humeana, realizada especialmente no Tratado da Natureza Humana, sobre a alternatividade entre a razão e a imaginação na questão do ceticismo sobre o mundo exterior e concernente à identidade pessoal. Partindo dessa síntese da questão, investiga em que sentido, para Cavell, a instabilidade do ceticismo reflete sua natureza dicotômica face ao ordinário; a naturalidade e a antinaturalidade da filosofia. A intenção é mostrar, com base nesse percurso, que, dado o fato de que as noções filosóficas não são descobertas sobre as crenças comuns e que estas não conseguem evitar por completo as tendências da razão humana, a ideia de uma filosofia imersa no mundo ordinário só pode ser compreendida como uma apropriação subjetiva dos nossos acordos comuns.

Palavras-chave: ceticismo; filosofia; crenças naturais; linguagem ordinária.
Políticas del espacio público en Buenos Aires
Authors: Ramírez Casas Jimena 
Published: February 2021

El espacio público no es único, neutral, ni universal. Subordina de manera diferente a las personas –hombres, mujeres y disidencias–, no sólo debido a la diferencia de cuerpos sexuados, sino a los distintos usos que hacemos según los roles que nos han sido asignados. En ese sentido según estén configurados los espacios públicos pueden coartar o habilitar actividades, libertades y movimientos. Las tensiones cotidianas de la vida urbana se materializan en el espacio público gracias a los diversos modos de apropiación y representación. El propósito de este trabajo es reflexionar sobre la gestión de los espacios públicos, tomando como referente empírico el barrio porteño de Puerto Madero. Sobre la base de un abordaje cualitativo, apoyado en el análisis de fuentes secundarias y en la discusión conceptual del espacio público, la desigualdad y la justicia espacial, este trabajo analiza algunas de las políticas de gestión del espacio público porteño con una perspectiva de género.
Política, federalismo y descentralización.
Authors: Aminahuel Aimé 
Published: February 2021

Con el advenimiento de la pandemia causada por el COVID-19, los Estados debieron enfrentar la coyuntura a partir de reorientar sus políticas públicas para detener el avance del virus en los territorios y para intentar frenar las crisis económicas que genera la pandemia. Argentina es un caso para el estudio: por la eficacia “inicial” de sus primeras medidas reconocidas a nivel internacional y por la utilización estratégica del andamiaje institucional con el que se distribuye el poder en los territorios subnacionales. En este sentido, el presente artículo problematiza dos dimensiones específicas que caracterizan la historia institucional del país: el federalismo y la descentralización, para abordar las políticas públicas implementadas desde el Estado Nacional. Así, el artículo se desarrolla a partir de una revisión teórica sobre la literatura tradicional del tema y, sobre el final, se avanza en analizar por qué el Estado Nacional Argentino en coordinación con las Provincias y los Municipios, implementó las medidas más trascendentales en el contexto de pandemia; se argumenta que la descentralización y el federalismo fiscal -particularmente las transferencias no automáticas-, como así también, las definiciones políticas por parte del Ejecutivo Nacional, funcionaron como factores dinamizadores que facilitaron la estrategia de gestión del gobierno para enfrentar los desafíos que implicó la pandemia.
Veinte años de política exterior paraguaya.
Authors: Heduvan Julieta H. 
Published: February 2021

Hacer un recorrido por los últimos veinte años de la política exterior de Paraguay implica analizar seis gobiernos con particularidades propias y contextos históricos muy diversos. El período comprendido entre los años 2000 y 2020 inicia con el primer año de mandato cumplido por parte del ex presidente del Senado, Luis Ángel González Macchi, devenido en presidente luego de una importante crisis política, y concluye con la actual presidencia de Mario Abdo Benítez, habiendo atravesado sus primeros dos años de mandato, de los cinco años que corresponden. El estudio de estas dos décadas tendrá como objetivo el analizar los cambios y las continuidades presentes en la política exterior de Paraguay a lo largo de este período, centrando el foco de interés en la modificación o permanencia de un “estilo” de política exterior. Se prestará especial atención al carácter activo o reactivo que presenta la política paraguaya en cada gobierno de acuerdo a la capacidad de promover un proceso efectivo de planificación, formulación e implementación de un proyecto de política exterior, evaluando, a su vez, el establecimiento de posturas más dependientes o más autónomas frente a condicionantes provenientes tanto del orden externo como del plano doméstico.
HUMAN TRAFFICKING DALAM PANDANGAN HUKUM ISLAM (Studi Praktek Perbudakan Zaman Rosulullah)
Authors: Sodik Miftahol Fajar 
Published: February 2021

Human trafficking is a form of the early occurrence of slavery on earth, it happened long before the arrival of Islamic teachings even though the religion of that religion succeeded in erasing such civilization towards dignified human values. The arrival of Islamic religious teachings at first seemed to support human trafficking with the primary fact that the Prophet Muhammad and his followers were involved in slave ownership obtained from conquest as a result of a war, but this is an argument that departs from the negative analysis of the haters of Islam so that if the teachings of this religion are studied in a concrete way it will be revealed that Islam is trying to change a civilization in a very solution.
Keywords: ,,
Análisis psicométrico preliminar de la escala perfil de Impacto emocional COVID-19 en universitarios peruanos
Authors: Rodríguez de los Ríos Luis , Aliaga Tovar Jaime Ramiro , Peña-Calero Brian Norman , Quintana Peña Alberto , Flores Limo Fernando Antonio 
Published: February 2021

Se analiza y establece en este estudio de tipo instrumental (Ato, López-García, & Benavente, 2013), las cualidades psicométricas fundamentales del Perfil de Impacto Emocional COVID-19 (García Pérez & Magaz, 2020), con la finalidad de utilizarlo a posteriori en la población de estudiantes universitarios con relación al impacto emocional generado por los efectos de este virus en la población de Lima. En una muestra de 161 estudiantes universitarios (117M; 44 V) de una edad promedio de 23 años (RIQ = 3), se administró un formulario virtual del Perfil, estimándose la validez analizando su estructura interna empleando un análisis factorial confirmatorio (AFC), intercorrelacionando los ítems de las cinco escalas del Perfil: ira/resentimiento, miedo, ansiedad, estrés y depresión, con el coeficiente policórico y empleando el estimador Weighted Least Square Mean and Variance Adjusted (WLSMV). Los índices resultantes muestran un ajuste empírico tipificado de excelente entre la estructura teórica del Perfil y los datos colectados (χ² = 426.83, gl = 265, CFI = .970, TLI = .966, RMSEA = .062, SRMR = .079). Por otro lado, la fiabilidad de las cinco escalas calculadas por los coeficientes alfa y omega, arrojaron resultados elevados (>.85). Estas excelentes cualidades psicométricas avalan el uso del Perfil en procesos de investigación sobre efectos emocionales del COVID-19.
Valores literarios en Los ríos profundos
Authors: Collado Román Humberto 
Published: February 2021

Los valores literarios forman la mente y el corazón de los estudiantes, impactando a unos más que otros, según nuestra sensibilidad y el hábito en la lectura de los libros.
De esta forma aprendemos el sentir del alma de los hombres, mediante la literatura: “La lectura, aunque sea fragmentaria, de Homero, Shakespeare, Balzac, Dostoievski y Martí, puede enseñarnos, más sobre la condición humana que el resto de nuestro saber”. (Espinoza, 1992).
En cambio, para Max Scheler los valores son aprendidos en una manera: emotiva, psicológica, lógica y del pensamiento. Siendo una de las características de los valores la jerarquía (éticos y estéticos), la cual gradúa los valores concebidos en forma a priori: “Valores sensibles: agradable- desagradable, gozar-sufrir. Valores vitales: salud, vejez, muerte. Valores espirituales: estéticos, jurídicos, gnoseológicos, etc. Valores religiosos: felicidad, desesperación, amor, entre otros; llegando a descubrir el odio, el amor, el acto moral”. (como se citó en Morrero, 1913).
Como vemos los valores son importantes en la vida de la cultura de la sociedad y de los hombres. Siendo importante buscar el nexo entre la cooperación entre unos y otros.
Gestión administrativa y el desempeño docente en un centro de idiomas de Lima Metropolitana
Authors: Chumpitazi Medina Farrath Piera 
Published: February 2021

En este artículo se realiza una reflexión sobre la gestión administrativa y el desempeño docente en un centro de idiomas de Lima Metropolitana.
Las dimensiones de la gestión cobran importancia ante la necesidad de definir, delimitar y conceptualizar los ámbitos de competencia en el complejo fenómeno social de la educación formal. Por otra parte, el profesor de lengua extranjera tiene como competencias la aplicación de saberes, para dar una respuesta a las situaciones a las que se enfrenta en su actividad profesional. El presente trabajo se elabora pensando que definiendo y comprendiendo los conceptos de la gestión administrativa y el desempeño docente se promoverá mejores prácticas educativas tanto para la institución como el alumnado.
Cathode luminescence analysis of Cu(In,Ga)Se2 solar cells treated with thiourea solution
Authors: Nakada Kazuyoshi , Nishimura Takahito , Suyama Naoki , Yamada Akira 
Published: February 2021

Abstract
Cross-sectional cathode luminescence (CL) was performed on working Cu(In,Ga)Se2 (CIGS) solar cells to clarify the mechanism behind the performance improvement of solar cells subjected to a thiourea treatment. The low panchromatic CL intensity at the depletion zone demonstrates that the existent electric field sweeps the carriers nearby, lowering their possibility of non-radiative and radiative recombination. Accordingly, the low CL intensity at grain boundaries are not necessarily caused by high non-radiative recombination rate if band bending is present. The photon energy mapping showed an emission distribution according to the double-graded bandgap profile. A blue shift in photon emission at the minimum bandgap area was observed for the thiourea-treated sample. We presume that S ions provided by the thiourea solution passivate subgap defects such as donor-type Se vacancies, resulting in radiative transitions with higher energies and higher net carrier density that eventually contributed to the higher fill-factor and higher open-circuit voltage.
The Training of Hatching Egg Skills as an Effort to Provide Kampong Chicken Seeds at Farmer Groups in Loa Village, Paseh District, Bandung Regency
Authors: Sujana Endang , Widjadtuti Tuti , Setiawan Iwan , Tanwiriah Wiwin , Garnida Dani , Asmara Indrawati Yudha 
Published: February 2021

Loa Village is one of the villages located in Paseh District, Majalaya, Bandung Regency. Loa Village has potential to be developed, in the field of animal husbandry. Many of the resident raising the chicken and duck in groups, but still use the traditional method, which is naturally hatching eggs by the hen so that it is difficult to get Kampong chicken seeds. With the village profile as above, we are challenged to provide the knowledge and techniques of raising Kampong chickens to Loa Village public, especially to farmer group members, through the virtual KKN-PPMD Padjadjaran University. The purpose of this activity is to increase the knowledge and skills of breeders in raising chickens, hatching eggs, composing the rations, processing chicken products and increasing the production of day old chicks. Apparently, the enthusiasm of the participants to gain knowledge and skills in raising Kampong chicken was quite high. Knowledge of the participants regarding the management of chickens, the preparation of rations are still lacking, but the enthusiasm of farmers to learn all the knowledge about raising Kampong chickens is very good, so that this activity can increase knowledge about how to hatch eggs and skills to operate the incubator and have a great passion for the business of Kampong chickens.
Abstrak
Desa Loa merupakan salah satu desa yang berada di Kecamatan Paseh, Majalaya Kabupaten Bandung. Desa Loa memiliki potensi yang harus dikembangkan, salah satunya yaitu potensi di bidang peternakan. Banyak dari penduduknya yang merupakan kelompok peternak ayam dan entok, tetapi masih menggunakan cara trasional yaitu menetaskan telur secara alami oleh induk sehingga sulit mendapatkan bibit ayam kampung. Melihat profil desa seperti di atas, maka kami tertantang untuk memberikan pengetahuan tehnik beternak ayam kampung kepada para anggota kelompok tani melalui Kegiatan KKN-PPMD virtual universitas Padjadjaran kepada masyarakat Desa Loa khususnya kepada kelompok peternak. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan dan keterampilan peternak dalam budidaya beternak ayam, menetaskan telur, menyusun ransum, dan pengolahan hasil ternak ayam serta meningkatkan produksi anak ayam untuk bibit. Dari kegiatan ini antusiasme peserta untuk memperoleh pengetahuan dan keterampilan usaha budidaya beternak aym lokal cukup tinggi. Wawasan peserta mengenai tatalaksana pemeliharaan ayam, serta penyusunan ransum masih sangat kurang, tetapi animo peternak sangat baik untuk belajar semua pengetahuan tentang budidaya beternak ayam lokal, sehingga kegiatan ini dapat meningkatkan pengetahuan mengenai cara-cara menetaskan telur dan keterampilan mengoperasikan cara menetaskan telur dengan mesin tetas dan semangat untuk usaha beternak ayam kampung.
Effort to Prevent COVID-19 STIKES Samarinda (STIKSAM) by Distributing Hand Sanitizer in Air Hitam Village of Samarinda City
Authors: Syamsul Eka Siswanto , Supomo  , Ansyori Achmad Kadri 
Published: February 2021

Due to the COVID-19 pandemic outbreak, the availability of handwashing products in Samarinda City has become a rare item. The purpose of this activity is to prevent COVID-19 through the use of Hand Sanitizer. This method in this service includes several stages, namely preparation that includes the preparation of tools and materials, the production process with the stages of mixing materials into hand sanitizer products, and the packaging process that is inserting the finished hand sanitizer into small bottles measuring 20 ml, 100 ml and Container 5 L, as well as labelling the brand hand sanitizer, and subsequently the distribution process in RT 27, 28 , 29 and 30 Black Water Village. Civitas Akademika STIKES Samarinda (STIKSAM) and Ikatan Keluarga Alumni (IKA STIKSAM) make hand sanitizer in accordance with WHO regulations, hand sanitizer distribution process in rt 27, RT 28, RT 29 and RT 30 Black Water Village and COVID-19 referral hospital (AW Hospital. Sjahranie and I.A. Moeis Hospital) went smoothly. Mayor of Samarinda H. Syaharie Ja'ang appreciated and reviewed the activities of Hand Sanitizer making at STIKES Samarinda campus.
Abstrak
Akibat wabah pandemi COVID-19 ketersediaan produk pencuci tangan di Kota Samarinda menjadi barang langka. Tujuan kegiatan ini yaitu melakukan upaya pencegahan COVID-19 melalui penggunaan Hand Sanitizer. Metode pada pengabdian ini meliputi beberapa tahap yaitu persiapan yang meliputi penyiapan alat dan bahan, proses produksi dengan tahapan pencampuran bahan-bahan menjadi produk hand sanitizer, dan proses pengemasan yaitu memasukan hand sanitizer yang sudah jadi ke dalam botol-botol kecil berukuran 20 ml, 100 ml maupun Dirigen 5 L, serta labelling merek hand sanitizer, dan selanjutnya proses pendistribusian di RT 27, 28, 29 dan 30 Kelurahan Air Hitam. Civitas Akademika STIKES Samarinda (STIKSAM) dan Ikatan Keluarga Alumni (IKA STIKSAM) membuat hand sanitizer sesuai ketentuan WHO, proses pendistribusian hand sanitizer di wilayah RT 27, RT 28, RT 29 dan RT 30 Kelurahan Air Hitam dan Rumah sakit rujukan COVID-19 (RSUD AW. Sjahranie dan RSUD I.A. Moeis) berjalan dengan lancar. WaliKota Samarinda H. Syaharie Ja’ang mengapresiasi dan meninjau kegiatan pembuatan Hand Sanitizer di kampus STIKES Samarinda.
PHYTОPREPARATIONS EFFICIENCY IN THE COWS NUTRITION
Authors: Prudyus Т. , Kyryliv Ya. 
Published: February 2021

In order to increase the intensity of livestock development and obtain safe products such as meat and milk, it is of great importance to provide cows with qualitative feed and optimal maintenance. An important role is devoted to the animal health because it directly affects productivity. The use of poor quality feeds leads to animal health deteriorating, reduced productivity.
Dis-balance of the gastrointestinal microbiota leads to poor food intake and clinical manifestations of disease.
In order to increase feed efficiency and productivity indexes, were used extracts of essential oils contained in the feed additive "Activo". This supplement with its properties stimulates feed intake, digestion, has bactericidal and anti-stress properties with positive effect on animal health and productivity.
The experiment revealed a positive effect of feed additive "Activo" on cows’ organism after calving and at the beginning of lactating. The influence of essential oils extracts contained in the feed additive "Activo" on the feed intake and digestion, milk production, protein and fat levels has been studied. There is a systematic dependence on feed intake increasing to milk yield. At the same time, indexes of quality such as fat and protein content were almost stable. According to the experimental results, it is possible to recommend milk producers to use "Activo" as part of cow feed with the aim to improve health and productivity.