bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a Formal Semantics for the Process Model of the Taverna	Workbench. Part II
Authors: Sroka Jacek , Hidders Jan 
Published: December 2024

Workflow development and enactment workbenches are becoming a standard tool for conducting in silico experiments. Their main advantages are easy to operate user interfaces, specialized and expressive graphical workflow specification languages and integration with a huge number of bioinformatic services. A popular example of such a workbench is Taverna, which has many additional useful features like service discovery, storing intermediate results and tracking data provenance. We discuss a detailed formal semantics for Scufl - the workflow definition language of the Taverna workbench. It has several interesting features that are notmet in other models including dynamic and transparent type coercion and implicit iteration, control edges, failure mechanisms, and incominglinks strategies. We study these features and investigate their usefulness separately as well as in combination, and discuss alternatives. The formal definition of such a detailed semantics not only allows to exactly understand what is being done in a given experiment, but is also the first step toward automatic correctness verification and allows the creation of auxiliary tools that would detect potential errors and suggest possible solutions to workflow creators, the same way as Integrated Development Environments aid modern programmers. A formal semantics is also essential for work on enactment optimization and in designing the means to effectively query workflow repositories. This paper is the second of two. In the first one [13] we have defined, explained and discussed fundamental notions for describing Scufl graphs and their semantics. Here, in the second part, we use these notions to define the semantics and show that our definition can be used to prove properties of Scufl graphs.
تداعيات الحركة الثورية الهنغارية 1848-1849
Authors: حضير ا. م. د. نرجس كريم 
Published: December 2024

تعد الثورة الهنغارية لعام 1848-1849 واحدة من اروع الثورات التي شهدتها القارة الاوربية, والتي تأثرت برياح ثورة شباط 1848 في فرنسا, فقد اشعلت ثورة شباط الفرنسية الثورات في جميع انحاء اوربا ضد الحكم المطلق لآل هابسبورغ وآل بوربون. وقد سجل خلالها الهنغاريين اروع صور البطولة لمواجهة الاستبداد الامبراطوري لحكومة ال هابسبورغ, من اجل التخلص من الظلم والاضطهاد وعدم المساواة الذي كان يعاني منها الهنغاريين, وقد شملت الثورة اجزاء واسعة من البلاد بهدف احداث تغيير كامل في النظام السياسي والاجتماعي والاقتصادي.
وقد ادت وسائل الاعلام ممثلة بالصحف والمجلات دوراً هاماً في ابقاء الشعب على اطلاع بالتطورات السياسية. ودعم الشعراء الهنغاريين امثال ساندور بيتوفي ويانوس اراني حركة الاصلاح وساهموا فيها بشكل كبير.
استطاع القادة الهنغاريين الليبراليين بمعية قواتهم تحقيق انتصارات منشودة في بداية الثورة واجبار الامبراطور فرديناند على اعلان دستور للبلاد يضمن استقلالها والحقوق المدنية لشعبها وفرض الضرائب تحت سيطرة البرلمان وحرية تكوين الجمعيات, لكن الامور فيما بعد خرجت من نطاق السيطرة لاسيما بعد استنجاد الامبراطور جوزيف, الذي خلف عمة, بالقوات الروسية التي اعلنت استعدادها, بصفتها رائدة الحلف المقدس الرافض والمناهض لكل عمل ثوري, فكان نهاية الامر انتهاء الثورة وقمعها في هنغاريا وتمكن القوات النمساوية من احكام قبضتها على البلاد وارجاعها الى وضعها السابق ان لم يكن اس
سياسة الفاطميين اتجاه الأندلس(358هـ-567ه)
Authors: قاسم عبير عهد 
Published: December 2024

تعتبر فترة توسع الفاطميين في المغرب فترة مهمه في تاريخ الدولة الفاطمية حيث بدا الفاطميون في التفكير في غزو الاندلس من الغرب وارادوا نشر المذهب الامامي هناك على ان يكون المغرب الاسلامي قد خضع لهم بالكامل .ومع ذلك لم يسمح الاموين في الاندلس للفاطميين بالوصول الى الاندلس وكان الخليفة الاموي هناك هو الناصر لدين الله وكان حاكما مشهور بشده بطشه تم تعزيز الثغور الأندلسية الجنوبية لمواجهه المغرب لحمايتها من اي هجوم فاطمي.
بلغ النزاع السياسي بين الفاطميين في المغرب في الاندلس اوجهه حيث عمد عبد الرحمن الناصر الى تقويه اواصر الصداقة والتحالف مع البيزنطيين .
تكمن اهميه هذا الموضوع بانه يدرس حقبه تاريخه مهمه من تاريخ الاسلام اذ يتكلم عن النزاع الذي حصل مآبين المسلمين انفسهم وكان هذا الصراع يصب لصالح الدولة البيزنطية المعادية للإسلام والمسلمين .
Pancreas in the elderly and senile age
Authors: Gubergrits N. B. , Gomozova O. A. 
Published: December 2024

A rise in the incidence of age-related maladies, which coincides with an increase in life expectancy, is the most significant issue in clinical medicine. These include pancreatic injury, which manifests primarily as progressive exocrine pancreatic insufficiency (EPI). Chronic abdominal ischemic syndrome is the etiological and pathogenetic basis of the syndrome of “aging digestive organs,” including the “aging” pancreas.
Age-related changes in the pancreas include a decrease in the volume of juice and the secretion of pancreatic enzymes due to the progression of fibrosis and atrophy of the pancreas parenchyma caused by the development of chronic ischemia as a result of arterial wall thickening and a decrease in blood flow in the pancreas. Lipoidosis, in which adipose tissue is primarily located around the lobules, and steatosis (fat droplets within the acinar cell) are among the potential causes of the “aging” pancreas.
The pancreas develops cystic dilatation of the ducts as it ages. The diameter of the ducts increases with age not only at the pancreas periphery but also at the head, body, and tail.
General age-related changes, such as atherosclerotic decrease in perfusion, cause specific changes in the pancreas, including a decrease in the volume of functionally active parenchyma, a decrease in the production of enzymes, and a decrease in the volume of secretions, which are manifested by EPI symptoms. EPI and specific age-related changes in the form of a decrease in food intake contribute to maldigestion with a deficiency of fat-soluble vitamins and the development of secondary clinical consequences, such as osteoporosis, which is both age-related and associated with vitamin D deficiency and changes in calcium metabolism.
In the elderly and senile age, patients have both EPI and endocrine insufficiency — diabetes mellitus — since both acinar and islet tissue of the pancreas are affected due to chronic abdominal ischemia.
Clinical manifestations of chronic ischemic pancreatopathy include unstable defecation, diarrhea or constipation, flatulence, malabsorption, decreased tolerance to food load, and weight loss due to decreased pancreatic function. It is important to observe that the pain syndrome is either absent or mildly manifested in these patients.
To treat EPI, a minimum number of medications corresponding to level A of evidence-based medicine must be administered. Mini-microsphere double-coated enzyme preparation Creon® 10 000, 25 000 FIP (the “gold standard” of replacement therapy) meets these requirements. Creon® capsules dissolve in the stomach, which enables the Creon minimicrospheres® to be released from the capsules in the stomach and then freely pass through the pylorus and enter the duodenum, where the coat of the Creon minimicrospheres® dissolves rapidly and enzymes begin to act, contributing to the hydrolysis of nutrients.
Experience in performing and detailing the indications for organ- and function-preserving surgery for chronic pancreatitis based on the classification
Authors: Klimenko V. M. , Klimenko A. V. 
Published: December 2024

The authors examined and operated on 54 chronic pancreatitis (CP) patients with pancreatic ductal hypertension. The diagnosis was confirmed according to the clinical course of CP; ultrasound, endosonography, CT, MRI, levels of endogenous insulin, parathyroid hormone, tumor marker CA 19-9, and fecal elastase 1; and intraoperative biopsy material from the head, body, and tail of the pancreas with fibrosis staging (F1–4).
We divided the patients into two groups. The main group included 28 (51.9%) patients, and the comparison group included 26 (48.1%) patients. A therapist and surgeon carefully observed patients in the main group. In compliance with detailed indications (pancreatic ductal hypertension and subcompensated exocrine insufficiency) and presented clinical classification, they underwent an organ-preserving surgery: a complete longitudinal pancreaticoduodenopapillotomy with isolated pancreaticojejunoduodenoanastomosis. The essence of the surgery is a longitudinal total dissection of the main pancreatic duct from the tail of the pancreas through the body and head. The longitudinal section ends with a dissection of the major duodenal papilla and its orifice, as well as the posteromedial wall of the duodenum, 1.5–2 cm long.
Patients in the comparison group underwent the same surgery but were hospitalized on a general basis without targeted supervision by a therapist and surgeon before the surgery.
All 28 patients (100%) in the main group had good long-term results, whereas only 2 (7.7%) in the comparison group did. The quality of life of patients in the main group corresponded to healthy individuals, and the functional state of the pancreas was at the level of subcompensation. According to the study, careful monitoring of the onset of pancreatic ductal hypertension and a decrease in the functional reserve of the pancreas in patients with CP, as conducted in the main group, allows us to determine the indications for timely organ-preserving surgery, which guarantees a high level of quality of life in the long-term perspective.
Changes in the regulation of the immune response in acute necrotizing pancreatitis complicated by multiple organ failure
Authors: Rotar O. V. , Khomiak I. V. , Poliovy V. P. , Hrama O. V. 
Published: December 2024

Timely identification of patients with severe acute necrotizing pancreatitis (ANP) is one of the main problems of the modern strategy for its treatment.
Aim: To study the cytokine regulation of the immune response in patients with ANP complicated by multiple organ failure (MOF).
Material and methods: We conducted a prospective cohort study of 22 patients with ANP complicated by MOF who were treated in the clinic during 2014–2020. We studied changes in blood cells expressing clusters CD11a+, CD162+, CD95+, CD16+, HLA-DR+ molecules, and levels of interleukins IL-2, IL-4, and IL-6. The efficacy of treatment was estimated by MOF duration, the level of postoperative complications, and mortality.
Results: Patients with ANP complicated by MOF exhibited a simultaneous observation of a low level of expression of CD11a+ and CD162+ on immunocompetent cells, along with a 2-fold lower content of CD95+ cells. This contributed to a decrease in the concentration of IL-6, accompanied by a slight increase in IL-4. A permanent decrease in the content of CD11a+-, CD162+- and CD95+-leukocytes simultaneously with a decrease in the concentration of IL-4 and an excessive increase in the levels of IL-2 and IL-6 was associated with a negative course of the disease.
Conclusion: The imbalance in the cytokine regulation of the immune response occurs in patients with ANP complicated by MOF. Patients with an unfavorable disease course in the absence of IL-4 exhibit a progressive and excessive increase in plasma concentrations of IL-2 and IL-6.
Irritable bowel syndrome: a modern perspective on epidemiology, pathophysiology, and treatment through the lens of the gut microbiome
Authors: Gubergrits N. B. , Mozhyna T. L. , Byelyayeva N. V. 
Published: December 2024

Irritable bowel syndrome (IBS) is a functional pathology, the prevalence of which has recently increased significantly in our country, with a corresponding rise in the number of male patients and the predominance of the psycho-emotional factor in the genesis of the disease. The development of IBS is a consequence of the dysfunction of a bidirectional pathway known as the “probiotics — gut — brain” axis. Microbial communities inhabiting the intestines take an active part in ensuring gastrointestinal health as well as in the formation and maintenance of mental health.
Probiotics, in particular psychobiotics that synthesize several neurotransmitters and neuromediators, are recognized as one of the key factors determining the successful functioning of the “probiotics-gut-brain” axis. It is suggested that psychobiotics produce bacterial extracellular microvesicles that can be absorbed from the gastrointestinal tract, enter the brain, deliver their intracellular contents to the central nervous system, improve neuronal function, and probably also provide astrocytes with glycolytic enzymes that contribute to neuroprotection. Some probiotic strains/mixtures simultaneously have a positive effect on the state of the enteric and central nervous systems, reducing the symptoms of IBS and reducing stress, anxiety, and depression. The article presents evidence of the highest level — meta-analyses and systematic reviews — that confirm the efficacy and safety of the use of probiotics in IBS treatment and reveal the molecular mechanisms of action of psychobiotics.
Probiotic Lactiale® Multi, based on a prototype with proven efficacy and safety, contains 14 probiotic strains that help improve the condition of patients with IBS, reduce abdominal pain, and improve the quality of life of patients. Probiotic Lactiale® Multi is theoretically able to improve the psycho-emotional state of patients due to the microorganisms that synthesize various neurotransmitters. Probiotic Lactiale® Multi can be considered the first national psychobiotic with proven effectiveness, indirectly recommended by World Gastroenterology Organisation experts for the treatment of IBS.
Bone marrow and tumor metastasis: tumor — organism interaction
Authors: Kajryak O. V. 
Published: December 2024

The combination of thrombosis and the progression of malignant tumors is a well-known fact. However, the reason for this observed pattern remains unclear. The megakaryocyte, a polyploid cell containing up to 64 haploid sets of human chromosomes, detaches platelets in the bone marrow. Megakaryocytes function not only as hematopoietic cells but also as cells involved in innate immunity. Researchers discovered a phenomenon called emperipolesis in the second half of the 20th century. During emperipolesis, cell coexistence is observed: the host cell phagocytoses the guest cell without lysing it, allowing for the mutual exchange of intracellular contents. With this phenomenon, mutual exchange of intracellular contents is possible. Emperipolesis occurs normally in human bone marrow in 4–6% of cases and increases in stress and chronic inflammation. Besides the neutrophils, the “guests” of the megakaryocyte are macrophages and lymphocytes. In addition to emperipolesis, extracellular vesicles transmit tumor information to bone marrow progenitor cells. Next, the information is transmitted to platelets that contribute to the formation of a blood clot, facilitating the adhesion of both exosomes and circulating tumor cells. Targeted delivery of exosomes and lymphocytes to the target tissue is carried out by adhesion molecules — integrins. They determine both intercellular interaction and cooperation between the parenchyma and the stroma. Integrins are the creators of tissue architecture, as they connect components of the intercellular matrix with the cytoskeleton. These molecules are capable of transmitting information bidirectionally — from the cell to the intercellular environment and vice versa — from the environment to the cell.
Thus, during metastasis of malignant tumors, nucleic acids of a tumor nature from neutrophils, macrophages, exosomes, and memory B cells enter the bone marrow. Due to this, the megakaryocyte receives tumor-specific nucleic acids. The megakaryocyte subsequently transmits this information to platelets. We suggest another way that metastasis might start: it could be through the bone marrow, where cells involved in hematopoiesis can stay for years or even decades. These cells may have received nucleic acids that can turn them into cancer cells or start metastases growing.
Aprendizaje colaborativo y la pedagogía de la educación física en niños con rasgos autistas
Authors: Aguas Liquinchana Mónica Gabriela , Taro Joseph 
Published: December 2024

Introducción. El Trastorno del Espectro Autista (TEA) presenta desafíos en educación física debido a dificultades en interacción social, motricidad y comunicación. Objetivo. Demostrar el impacto del aprendizaje colaborativo en las dimensiones del proceso de enseñanza aprendizaje PEA en clases de educación física. Metodología. Se empleó un diseño mixto explicativo secuencial, con un enfoque cuantitativo preexperimental y un análisis cualitativo fenomenológico. Participaron 29 niños (27 sin necesidades educativas especiales (NEE) y 2 con TEA), evaluados en cinco dimensiones del PEA (interacción social, desempeño motriz, cognición, inclusión y rol docente) mediante una ficha validada (α=0,868). Los datos se analizaron estadísticamente y mediante análisis temático de entrevistas. Resultados. Se encontraron mejoras significativas en todas las dimensiones evaluadas (p≤0,05). Los niños con TEA mostraron avances en interacción social e inclusión, reflejando mayor disposición para colaborar y sentido de pertenencia. En desempeño motriz y cognición, las actividades grupales facilitaron su aprendizaje y adaptación. El rol docente fue clave para mediar, adaptar actividades y reforzar comportamientos positivos. Conclusión. El aprendizaje colaborativo es una metodología inclusiva y efectiva que mejora habilidades sociales, motrices y cognitivas, promueve la cohesión grupal y reduce desigualdades en el PEA. Estos hallazgos destacan la importancia del docente como mediador y validan el aprendizaje colaborativo como una herramienta esencial en la pedagogía inclusiva. Área de estudio general: Psicopedagogía. Área de estudio específica: Educación Física. Tipo de estudio: Artículos originales.
Sistematização da trajetória de inovação administrativa no Ministério Público Federal
Authors: Santiago Coutinho de Miranda Daniel 
Published: December 2024

O artigo parte da premissa de que a inovação é uma das formas do Ministério Público Federal atender aos anseios da sociedade e de cumprir a sua missão institucional de “defender a ordem jurídica, o regime democrático, os interesses sociais e individuais indisponíveis e promover a justiça”. Dito isso, busca-se compreender, em âmbito administrativo, qual foi a trajetória da inovação na instituição estudada, organizando e sistematizando as informações, por meio de uma pesquisa documental em diários oficiais e portais eletrônicos. Os resultados demonstram que o MPF tem forte necessidade de institucionalizar a inovação, prevendo-a dentro de regras e normas. Desde 2010 o tema passou por três ciclos de evolução, demarcados inicialmente pela publicação de seu planejamento estratégico institucional, avançando para a criação de estruturas organizacionais dedicadas à inovação e concluindo para um ciclo de criação de laboratórios de inovação.
Palavras-Chave: Ministério Público Federal. Inovação. Organização pública. Ecossistema de justiça.

Abstract
The article is based on the premise that innovation is one of the ways for the Federal Prosecution Service to meet the society's expectations and fulfill its institutional mission of "defending the legal order, the democratic regime, social and unavailable individual interests, and promoting justice." That said, the aim is to understand, at an administrative level, the trajectory of innovation in the studied institution by organizing and systematizing the information through a documental research in official gazettes and electronic portals. The results show that the Federal Prosecution Service has a strong need to institutionalize innovation, foreseeing it within rules and regulations. Since 2010, the topic has undergone three cycles of evolution, initially marked by the publication of its institutional strategic planning, advancing to the creation of organizational structures dedicated to innovation, and concluding with a cycle of creating innovation laboratories.
Keywords: Federal Prosecution Service. Innovation. Public organization. Justice ecosystem.
Development of the «Dissolution» test method for vaginal suppositories Pimafucin®
Authors: Meleshko A. V. , Volkova A. M. , Tyukova V. S. , Panov A. V. , Kedik S. A. 
Published: December 2024

Introduction. «Dissolution test» for drugs is one of the key studies of control and, in many ways, is designed to simulate the bioavailability of the active substance under the conditions of use. However, there are several drugs containing active pharmaceutical substances that are poorly soluble under standard conditions. For this substances action is local, so, they are practically not absorbed in the human body, but showed the necessary therapeutic effect. This work discusses the development of conditions for «Dissolution test» in lipophilic-based suppositories containing natamycin, which is an antifungal agent related to tetraene macrolides, poorly soluble in water and, therefore, in standard buffer solutions intended for this test.Aim. Choose the conditions for conducting «Dissolution test», under which it will be possible to achieve complete release of the active substance from lipophilic-based suppositories on «Pimafucin» and «Primacin».Materials and methods. The objects of the study are lipophilic-based suppositories containing natamycin. The study was carried out using dissolution testers (Rotating Basket and Flow Cell apparatus) and an HPLC system to define the amount of natamycin released.Results and discussion. The research objects were analyzed under «Dissolution test». The work shows the possibility of conducting a test with complete release of the active substance by adding surfactants and an organic solvent, which is acceptable for quality control dissolution medias.Conclusion. Conditions for «Dissolution test» have been developed for suppositories containing natamycin.