bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managerial insights on sustainable practices in today's business: mapping economic, social, cultural, and environmental dimensions and their organizational outcomes
Authors: Ciuciuc Victor-Emanuel , Bunica Andreea , Biea Elena Adriana , Treapat Laurentiu-Mihai , Edu Tudor 
Published: January 2025

PurposeThis paper explores the integration of sustainable development practices within today’s business management, emphasizing the managerial perspectives and strategies adopted to address economic, social, cultural, and environmental dimensions of sustainability and their organizational outcomes, namely performance and reputation.Design/methodology/approachThrough a qualitative study involving in-depth interviews with twelve managers from various sectors, this research utilizes content analysis and Qualitative Data Analysis Software (AtlasTI) to map managerial insights and strategies. The study identifies key constructs and their impacts on organizational performance and reputation.FindingsThe study identifies a complex interplay between economic, social, environmental, and cultural management practices and their take on organizational performance and reputation in the current context and emphasizes the importance of leadership and regulatory frameworks in promoting sustainability.Research limitations/implicationsThe study’s qualitative approach provides in-depth insights but may limit generalizability. Future research could employ quantitative methods to validate and extend these findings across different contexts and industries.Originality/valueThis study contributes to the sustainability and business management literature by providing a detailed examination of how Romanian managers perceive and operationalize sustainability. It underscores the importance of integrating sustainability into core business strategies and offers practical insights for managers and policymakers aiming to enhance sustainable business practices.
What experts say about domestic violence: constructing Thailand’s domestic violence severity index through an expert judgement approach
Authors: Chokprajakchat Srisombat , Techagaisiyavanit Wanaporn , Mulaphong Dhanakorn , Iyavarakul Tongyai , Kuanliang Attapol 
Published: January 2025

Purpose
While many countries have adopted traditional approaches to identify patterns and trends in domestic violence at a national level, a strategy that provides more insightful information is still lacking. In response to this need, the purpose of this study is to propose the construction of a domestic violence severity index (DVSI) as an alternative. This index serves as a strategic instrument for policymakers and law enforcement agencies, enabling them to monitor changes in the overall severity of domestic violence incidents over time, beyond relying solely on the volume of reported incidents.

Design/methodology/approach
Reported domestic violence incidents are collected over the past five years (2019–2023) from the entire country. Unlike sentence-based approaches such as the Cambridge Crime Harm Index and the Canadian Crime Severity Index, the DVSI applies a crime severity index based on expert judgment to assess the seriousness of domestic violence categories. Twenty-three experts with extensive experience in domestic violence issues across various governmental and nongovernmental organizations participated in providing assessments. To ensure consistency in assigning weight values to the domestic violence categories, the average scores provided by experts were calculated using arithmetic mean, median, mode and geometric mean.

Findings
Domestic violence maps reflecting trends between 2019 and 2023 across 77 provinces in Thailand have been generated based on the index data. The maps depict significant serial and spatial correlation levels from 2019 to 2023.

Practical implications
These maps carry significant implications for the country’s domestic violence prevention strategy by offering detailed insights into the geographical locations and periods requiring focused attention and resource allocation from the government. This tool can also aid the public in gaining a better understanding of the prevalence of domestic violence in society, facilitating increased coordination and collaboration among stakeholders.

Originality/value
Many countries quantify domestic violence using simple methods, such as calculating percentages or measuring incidents per 100,000 population. However, a specific DVSI has not yet been developed to analyze and understand domestic violence trends geographically, which could serve as an additional measure to protect victims. In addition, the study uses an expert judgment approach, a rare method in constructing a crime severity index, especially in the context of domestic violence.
History and prospects of Nagashima‐type palmoplantar keratosis, the most common palmoplantar keratoderma in east Asian populations
Authors: Kubo Akiharu 
Published: January 2025

AbstractNagashima‐type palmoplantar keratosis (NPPK) has been shown to represent a form of autosomal recessive palmoplantar keratosis due to biallelic pathological variants of SERPINB7, which encodes a serine protease inhibitor expressed in the epidermis. Approximately 10 years have elapsed since NPPK was demonstrated to be an independent genetic disease, and the most prevalent palmoplantar keratoderma (PPK) in East Asian countries due to a high prevalence of founder mutations in SERPINB7. Since then, it has become evident that biallelic pathological variants of SERPINA12, which encodes a serine protease inhibitor expressed in the epidermis, can also manifest symptoms analogous to those of NPPK. Furthermore, a pathological variant of SERPINB7 was identified as a risk factor for the development of atopic dermatitis in a genome‐wide association study (GWAS) of atopic dermatitis, indicating that the frequent co‐occurrence of NPPK and atopic dermatitis is not a mere coincidence. Despite the documentation of NPPK cases in Japan since the 1970s, there have been no reports of individuals with similar symptoms from other regions, including Europe and the USA. Consequently, the existence and independence of the disease remained uncertain until its genetic cause was identified. The disease's independence was established through the accumulation of data on affected individuals, including the provision of accurate descriptions of their symptoms, which enabled the identification of the genetic cause. This review presents a comprehensive overview of the history and prospects of NPPK with a particular focus on the history of the process of establishing NPPK as an independent disease.
Dynamic changes in serum albumin and ferritin indicate higher risk of early‐onset peritonitis in peritoneal dialysis patients
Authors: Li Jinqing , Liu Yao , Lu Yijun , Fu Chensheng , Ye Zhibin , Zhang Zhenxing 
Published: January 2025

AbstractIntroductionThe objective of this study is to investigate the dynamic changes in serum albumin and ferritin as potential predictors for early‐onset peritoneal dialysis‐related peritonitis (PDRP) in patients undergoing peritoneal dialysis (PD).MethodsThis retrospective study included 215 patients with end‐stage renal disease who initiated PD at Huadong Hospital. Patients were followed up to 24 months, during which episodes of PDRP were recorded. The dynamic changes in serum albumin and ferritin levels were evaluated within the first 6 months of PD initiation. Data were analyzed to assess the relationship between these biomarkers and early‐onset PDRP.ResultsAmong the 215 patients, 33.49% developed PDRP, and 28.93% experienced early‐onset PDRP. Patients with lower baseline serum albumin levels (<35 g/L) and higher baseline ferritin levels (≥400 μg/L) had an increased risk of developing early‐onset PDRP. Importantly, the risk associated with low initial albumin was not significant when serum albumin levels remained stable within the first 6 months (−5% to 5% change). Similarly, although higher baseline ferritin was associated with a higher risk of early‐onset PDRP, patients with fluctuating ferritin levels (more than 35% change) showed no significant increase in the risk. Kaplan–Meier analysis revealed a lower cumulative technical survival rate in patients with early‐onset PDRP.ConclusionDynamic changes in serum albumin and ferritin levels within the first 6 months of PD can serve as significant predictors of early‐onset PDRP, but stable levels of these markers mitigate their predictive value. Close monitoring of these biomarkers may help in identifying high‐risk patients and improving PD outcomes.
Tidal–hydrological dynamics of water temperature across freshwater forested wetlands on the northeastern Pacific coast
Authors: Buenau Kate E. , Diefenderfer Heida L. , Mckeon Maggie A. , Borde Amy B. 
Published: January 2025

AbstractTidal freshwater forests were once extensive across temperate coastlines, but loss and fragmentation have made estimation of their ecosystem functions challenging. We measured water temperature for 2 years in three Sitka spruce tidal forests, a restoration site, and an adjacent emergent marsh on the Columbia River, Washington, United States. We assessed spatial variability of water temperature within sites including the effects of hydrology, differences among bay and tributary tidal forests, and differences between the tidal forests and the mainstem Columbia, the restoration site, and the emergent marsh. The tidal forests nearest to the bay had lower interior water temperatures than their channel confluences by up to 2.5°C (weekly median temperature) and 2.0°C (weekly maximum temperature), with most cooling occurring during the low‐flow months of July–September. Tributary sites had maximum temperatures up to 1.9°C cooler than bay sites and 4.2°C cooler than the mainstem. Temperatures in the two bay sites decreased by −0.16°C/100 m and −0.07°C/100 m, on average. The restoration site had the smallest within‐site temperature gradient. Differences in maximum temperatures were greatest when tidal range was low, while higher tidal ranges were associated with warmer and more variable site interiors relative to their confluences. These results suggest that water temperatures in these tidal forests can provide temperature refugia for cold water biota including salmon.
Mind the Gap: A Neural Network Framework for Imputing Genotypes in Non‐Model Species
Authors: Bougiouri Katia 
Published: January 2025

Reduced representation sequencing (RRS) has proven to be a cost‐effective solution for sequencing subsets of the genome in non‐model species for large‐scale studies. However, the targeted nature of RRS approaches commonly introduces large amounts of missing data, leading to reduced statistical power and biased estimates in downstream analyses. Genotype imputation, the statistical inference of missing sites across the genome, is a powerful alternative to overcome the caveats associated with missing sites. Typically, genotype imputation requires the presence of a reference panel of haplotypes, however, this is not always feasible for non‐model species. In this issue of Molecular Ecology Resources, Mora‐Márquez et al. (2024) develop gtImputation, an unsupervised machine learning imputation tool with an interactive GUI, which leverages information from the underlying data structure itself, without the need for a reference panel. They showcase that their method performs equally well and even surpasses existing haplotype‐clustering and unsupervised machine learning algorithms, particularly for sites with low minor allele frequency (MAF) and for data sets with strong underlying population structure. This innovative framework adds to the ongoing efforts to expand the applicability of imputation to non‐model species, offering the opportunity to apply varied types of analyses requiring dense sets of markers, while also maintaining lower sequencing costs.
Invasive mechanical ventilation strategies, adjuvants treatments and adverse events among ICU patients with COVID‐19 in Denmark
Authors: Nielsen Martine S. , Halekoh Ulrich , Perner Anders , Haberlandt Trine , Larsen Nikolai Arnold‐ , Weihe Sarah , Garcia Ricardo S. , Siegel Hanna , Hagdrup Christian , Skøtt Mads R. , Jensen Anne‐Mette S. , Frische Jonathan B. , Wethelund Kasper , Christiansen Søren H. , Aagaard Søren R. , Højlund Sofie , Westergaard Bo , Christiansen Aage , Michagin George , Worm Marie S. , Svendsen Ann‐Kristine M. , la Cour Kirstine N. , Jonassen Trine B. , Jensen Jens U. , Sørensen Kasper M. , Haase Nicolai , Rasmussen Bodil S. , Brøchner Anne C. 
Published: January 2025

AbstractAimTo describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and the occurrence of barotrauma and prolonged ventilation in ICU patients with COVID‐19 in Denmark, retrospectively.MethodsAll ICUs admitting COVID‐19 patients in Denmark from 10 March 2020 to 2 April 2021 were invited to participate. All patients with COVID‐19 who received invasive mechanical ventilation were included and data was retrospectively collected from electronic patient records.ResultsA total of 774 patients were invasively ventilated during the first two waves and included; 70% were males and the median age was 69 years. 340 (51.5%) of patients never exceeded tidal volumes of 8 mL/kg. For all patients, tidal volumes under 8 mL/kg were applied in 77.6% (IQR 54.5%–96.2%) of the time on ventilator in the ICU; plateau pressure was below 30 cm H2O in 125 (80.6%) patients; prone positioning was used in 44.7% of patients. In ICU, 169 of 774 (21.8%) patients experienced barotrauma and 220 (28.4%) prolonged ventilation. At 90 days, 306 (39.5%) had died.ConclusionsLung protective ventilation and prone positioning were used in many of the Danish ICU patients with COVID‐19, but barotrauma, prolonged ventilation and death occurred frequently.
Tgm2‐Catalyzed Covalent Cross‐Linking of IκBα Drives NF‐κB Nuclear Translocation to Promote SASP in Senescent Microglia
Authors: Li Zhiqiang , Wang Tianxiang , Du Sijing , Miao Zelong , Zhao Yujiao , Tang Yuxiang , Meng Xianbin , Yu Shangcheng , Zhang Dongyuan , Jiang Hao , Du Kunlin , Wei Wei , Deng Haiteng 
Published: January 2025

ABSTRACTMicroglia, as resident immune cells in the central nervous system (CNS), play a crucial role in maintaining homeostasis and phagocytosing metabolic waste in the brain. Senescent microglia exhibit decreased phagocytic capacity and increased neuroinflammation through senescence‐associated secretory phenotype (SASP). This process contributes to the development of various neurodegenerative diseases, including Alzheimer's disease (AD). In this study, we found that SASP was elevated in senescent microglia, and proteomics showed that Tgm2 was upregulated. Mechanistically, we revealed that Tgm2‐catalyzed covalent cross‐linking of IκBα at K22 and Q248 residues in the cytoplasm of microglia, resulting in the reduction of IκBα and nuclear translocation of NF‐κB to promote SASP production. Treatment of senescent microglia with Tgm2 inhibitors (Tg2‐IN1 and Cys‐D) resulted in reduced NF‐κB nuclear translocation and decreased SASP. Additionally, oral administration of Cys‐D significantly improved the aging phenotype in aged mice. To summarize, Tgm2 is a potential target for antiaging, and inhibitors of Tgm2 can serve as novel prophylactics or senomorphics.
Causal relationship between 14 micronutrients and chronic periodontitis: a Mendelian randomization study
Authors: Yu Z , Yang Y , Yu Z , Yan Z , Gao R 
Published: January 2025

ABSTRACTBackgroundChronic periodontitis is one of the most common inflammatory diseases worldwide. Micronutrients play a significant impact on health and periodontal disease progression. However, there is still a lack of conclusive studies confirming the causal association of micronutrients with chronic periodontitis.Materials and methodsGenome‐wide association study pooled data on chronic periodontitis were collected from the FinnGen consortium, and 14 micronutrients (calcium, copper, zinc, potassium, magnesium, selenium, iron, carotenoids, vitamin B6, B12, C, D, E and folate) were obtained from the OpenGWAS and UK Biobank Study. Instrumental variables were screened by strict criteria. Five Mendelian randomization (MR) methods were used. Finally, the robustness of the findings was verified by sensitivity analyses.ResultsWe found that vitamin D reduced the risk of chronic periodontitis (OR: 0.605, 95%CI: 0.398–0.921, P = 0.019). However, we had no evidence of a significant association between other micronutrients and chronic periodontitis. Multiple sensitivity analyses confirmed the robustness of the findings. A variety of sensitivity analysis methods confirmed the reliability of the results.ConclusionIn this study, we found a potential causal relationship between vitamin D and chronic periodontitis by MR analysis, whereas we did not find an association between 13 other micronutrients and chronic periodontitis. This result might provide new ideas for the prevention and treatment of chronic periodontitis to some extent. However, despite the rigorous analytical methods used in this study, this finding needs to be interpreted with caution. Further randomized controlled studies might provide more in‐depth references to the findings of this study.
Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies
Authors: Cavarocchi Emma , Drouault Maëva , Ribeiro Joao C. , Simon Violaine , Whitfield Marjorie , Touré Aminata 
Published: January 2025

AbstractBackgroundIn mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and motility. Primary motility of the sperm cells is acquired during their transit through the epididymis and hyperactivated motility is acquired throughout the journey in the female genital tract by a process called capacitation. These activation processes rely on the micro‐environment of the genital tracts. In particular, during capacitation, a panoply of ion transporters located at the surface of the sperm cells mediate complex ion exchanges, which induce an increase in plasma membrane fluidity, the alkalinization of the cytoplasm and protein phosphorylation cascades that are compulsory for sperm hyperactivation and fertilization potential. As a consequence, both structural and functional defects of the sperm flagellum can affect sperm motility, resulting in asthenozoospermia, which constitutes the most predominant pathological condition associated with human male infertility.ObjectivesHerein, we have performed a literature review to provide a comprehensive description of the recent advances in the genetics of human asthenozoospermia.Results and DiscussionWe describe the currently knowledge on gene mutations that affect sperm morphology and motility, namely, asthenoteratozoospermia; we also specify the gene mutations that exclusively affect sperm function and activation, resulting in functional asthenozoospermia. We discuss the benefit of this knowledge for patient and couple management, in terms of genetic counselling and diagnosis of male infertility as a sole phenotype or in association with ciliary defects. Last, we discuss the current strategies that have been initiated for the development of potential therapeutical and contraceptive strategies targeting genes that are essential for sperm function and activation.
Leptin action on ARC‐PVN neural circuit regulates ejaculation behavior by altering sympathetic neuroplasticity
Authors: Zhang Qi‐Jie , Luan Jiao‐Chen , Gu Qi , Song Ning‐Hong , Xia Jia‐Dong 
Published: January 2025

AbstractBackgroundAlthough some studies have revealed the close relationship between leptin and premature ejaculation in clinical practice, whether and how leptin participates in the regulation of ejaculatory behaviors are still unknown.ObjectiveTo explore the role of leptin on ejaculatory behaviors and its underlying mechanism.Materials and methodsCopulation behavior tests were performed after acute and chronic leptin administration at peripheral and central levels. To compare changes in sympathetic nervous system activity, lumbar sympathetic nervous activity, serum noradrenaline levels, and the distribution of sympathetic fibers in vas deferens and seminal vesicles were analyzed. Construction of virus vector, immunohistochemistry, and optogenetics techniques were used to explore the neural circuit mechanism. The density of dendritic spines in parvocellular region of paraventricular nucleus was measured by Golgi staining.ResultsAcute administration of leptin had no effect on ejaculation behavior in male mice. However, both mount latency and ejaculation latency were significantly shortened, even if serum leptin decreased to normal level, after chronic administration of leptin at peripheral or central level. Additionally, sympathetic fibers in vas deferens and seminal vesicles obviously increased, in which arcuate nucleus‒paraventricular nucleus circuit and glutamatergic neurons in paraventricular nucleus played an important role. Dendritic spine density in parvocellular region increased after chronic leptin administration.Discussion and conclusionThe role of leptin in regulating ejaculation behavior was chronic, not acute, in which leptin chronically modulated sympathetic neuroplasticity via arcuate nucleus‒paraventricular nucleus circuit and glutamatergic neurons in paraventricular nucleus and promoted ejaculatory behaviors. Increased dendritic spine density in parvocellular region of paraventricular nucleus may be involved as well.
Digital disparities in Myanmar: A case study for sustainable digitalization
Authors: Thida Myo , Thwe Khine Zar , Ko Thiha Ko , Thuya Han , Naing Hnin Ei Ei , Hlaing Hnin Oo Wai 
Published: January 2025

AbstractThis study explores the digital disparities in Myanmar, particularly in the Education Sector, and the challenges the country faces in achieving sustainable digitalization. Employing both quantitative and qualitative research methods, including surveys and interviews, the researchers collected data from online learner students across various regions in Myanmar to assess the digital skills gap and access to online education. The findings reveal significant digital divides exacerbated by the 2021 political crisis, with issues such as unstable internet access, frequent power outages, and financial constraints impeding progress. These challenges disproportionately affect rural and conflict‐prone areas. Despite efforts toward digitization, many students lack access to essential digital resources, further widening the digital gap. The study concludes that strategic interventions are necessary to address these disparities in Myanmar's digital future.