bluuebunny/crossref_metadata_2025_split huggingface dataset:
An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR)
Authors: Walimbwa Stephen I. , Kaboggoza Julian P. , Waitt Catriona , Byakika-Kibwika Pauline , D’Avolio Antonio , Lamorde Mohammed 
Published: November 2021

Abstract
Background
Remdesivir is a novel broad-spectrum antiviral therapeutic with activity against several viruses that cause emerging infectious diseases. The purpose of this study is to explore how commonly utilized antiretroviral therapy (tenofovir disoproxil fumarate/lamivudine [TDF/3TC] and atazanavir/ritonavir [ATV/r]) influence plasma and intracellular concentrations of remdesivir.

Methods
This is an open-label, randomized, fixed sequence single intravenous dosing study to assess pharmacokinetic interactions between remdesivir and TDF/3TC (Study A, crossover design) or TDF/3TC plus ATV/r (Study B). Healthy volunteers satisfying study entry criteria will be enrolled in the study and randomized to either Study A; N=16 (Sequence 1 or Sequence 2) or Study B; N=8. Participants will receive standard adult doses of antiretroviral therapy for 7 days and a single 200mg remdesivir infusion administered over 60 min. Pharmacokinetic blood sampling will be performed relative to the start of remdesivir infusion; predose (before the start of remdesivir infusion) and 30 min after the start of remdesivir infusion. Additional blood samples will be taken at 2, 4, 6, 12, and 24 h after the end of remdesivir infusion.

Discussion
This study will characterize the pharmacokinetics of remdesivir from a typical African population in whom clinical use is anticipated. Furthermore, this study will deliver pharmacokinetic datasets for remdesivir drug concentrations and demographic characteristics which could support pharmacometric approaches for simulation of remdesivir treatment regimens in patients concurrently using tenofovir/lamivudine and/or atazanavir/ritonavir.

Trial registration
ClinicalTrials.gov NCT04385719. Registered 13 May 2020.
A study on machine learning techniques for the schema matching network problem
Authors: Rodrigues Diego , Silva Altigran da 
Published: November 2021

AbstractSchema matching is the problem of finding semantic correspondences between elements from different schemas. This is a challenging problem since disparate elements in the schemas often represent the same concept. Traditional instances of this problem involved a pair of schemas. However, recently, there has been an increasing interest in matching several related schemas at once, a problem known asschema matching networks. The goal is to identify elements from several schemas that correspond to a single concept. We propose a family of methods for schema matching networks based on machine learning, which proved to be a competitive alternative for the traditional matching problem in several domains. To overcome the issue of requiring a large amount of training data, we also propose a bootstrapping procedure to generate training data automatically. In addition, we leverage constraints that arise in network scenarios to improve the quality of this data. We also study a strategy for receiving user feedback to assert some of the matchings generated and, relying on this feedback, improve the final result’s quality. Our experiments show that our methods can outperform baselines, reaching F1-score up to 0.83.
Terrain-based adaption of propagation model loss parameters using non-linear square regression
Authors: Isabona Joseph , Imoize Agbotiname Lucky 
Published: November 2021

AbstractReliable and real-time propagation loss modeling play a significant role in the efficient planning, development, and optimization of macrocellular communication networks in a given terrain. Thus, the need to adapt or tune an existing model to enhance its signal prediction accuracy in a specified terrain becomes imperative. In this paper, we proposed and applied a non-linear square regression method based on the Levenberg-Marquart (LM) algorithm to adapt and improve the empirical propagation loss estimation accuracy of the Egli model for two major cities in Nigeria. A comprehensive propagation loss measurement acquired over Long Term Evolution (LTE) mobile broadband networks operating at 2630 MHz for four different cities was collected using TEMS investigation tools to achieve the Egli model adaption. Results indicate that the adapted Egli model displays a high estimation accuracy over the Gauss-Newton (GN) algorithm leveraging the non-linear regression method employed to benchmark the propagation loss estimation. Using six standard statistical indicators, the adapted Egli model displayed lower estimation errors than the classical Egli model across the tested locations in the two cities investigated. Finally, the LM-adapted Egli model was compared with extensive measurements from another eNodeB in Port Harcourt different from the initial four eNodeBs investigated. The results indicate that the adapted model is suitable for deployment in related macrocellular environments.
Digital symptom monitoring with patient-reported outcomes in community oncology practices: A U.S. national cluster randomized trial.
Authors: Basch Ethan , Schrag Deborah , Jansen Jennifer , Henson Sydney , Stover Angela M. , Spears Patricia , Jonsson Mattias , Deal Allison Mary , Bennett Antonia Vickery , Thanarajasingam Gita , Reeve Bryce , Snyder Claire Frances , Bruner Deborah , Cella David , Kottschade Lisa A. , Perlmutter Jane , Miller Robert S. , Strasser Jon F. , Zylla Dylan M. , Dueck Amylou C. 
Published: November 2021

349527 Background: Symptoms are common during cancer care but often go undetected. Digital systems that elicit patient-reported outcomes (PRO) surveys may detect symptoms early and prompt clinicians to intervene, thereby alleviating suffering and averting complications. Methods: In a cluster-randomized trial, U.S.-based community oncology practices were randomized 1:1 to digital symptom monitoring with PRO surveys, or to usual care control. Patients receiving systemic treatment for metastatic cancer were eligible. At PRO practices, participants were invited to complete a weekly survey via web or automated telephone system for up to one year, including questions about nine common symptoms, performance status, and falls. Severe or worsening symptoms triggered electronic alerts to care team nurses, and reports showing longitudinal symptom data were available to oncologists at visits. Pre-specified secondary outcomes included impact on physical function, symptom control, and health-related quality of life (HRQL). The primary outcome of survival is not yet mature. Results: At 52 practices, 1,191 patients were eligible and enrolled (593 PRO; 598 control). Clinically meaningful benefits were experienced in physical function by 13.8% more patients with PRO versus control (P=0.009); symptom control by 16.1% (P=0.003); and HRQL by 13.4% (P=0.006). Mean changes from baseline were superior with PRO versus control for physical function (mean difference 2.47, 95% CI 0.41-4.53; P=0.02), symptom control (2.56, 0.95-4.17; P=0.002), and HRQL (2.43, 0.90-3.96; P=0.002). Patients completed 20,565/22,486 (91.5%) of expected weekly PRO surveys. Conclusions: Digital symptom monitoring during cancer treatment confers clinical benefits. Clinical trial information: NCT03249090.
<<Dentro la lingua avita>>. La nominazione in Viaggio terrestre e celeste di Simone Martini
Authors: Luzi Alfredo 
Published: November 2021

La poetica della parola è l’asse portante della scrittura di Mario Luzi, a partire dalle prime prove ermetiche impostate sull’idea neoplatonica della parola come rivelazione dell’essere fino agli assillanti interrogativi che intessono gli ultimi componimenti e che sono la traccia di un profondo dubbio epistemologico, non risolto dall’adesione del poeta alla fede cristiana.I saggi critici, che accompagnano come una sorta di autocommento la produzione in versi, sono disseminati da una serie di riflessioni sulla potenzialità dell’atto poetico che si configurano come complesso “itinerario del dicibile”.Nell’arco di più di mezzo secolo Luzi progressivamente innesta il concetto ebraico di davar a quello greco di logos, perno filosofico e teologico della poetica ermetica.
Parallel Lotteries: Insights from Alaskan Hunting Permit Allocation
Authors: Arnosti Nick , Randolph Tim 
Published: November 2021

We analyze the parallel lottery that is used to allocate hunting permits in the state of Alaska. Each participant is given tickets to distribute among lotteries for different types of items. Participants who win multiple items receive their favorite, and new winners are drawn from the lotteries with unclaimed items. When supply is scarce, equilibrium outcomes of parallel lotteries approximate a competitive equilibrium from equal incomes (CEEI), which is Pareto efficient. When supply is moderate, parallel lotteries exhibit two sources of inefficiency. First, some agents may benefit from trading probability shares. Second, outcomes may be “wasteful”: agents may receive nothing even if acceptable items remain unallocated. We bound both sources of inefficiency and show that each is eliminated by giving applicants a suitable number of tickets k: trades are never beneficial when k = 1, and waste is eliminated as [Formula: see text]. In addition, we show that the wastefulness of the k-ticket parallel lottery has some benefits: agents with strong preferences may prefer parallel lottery outcomes to those of any nonwasteful envy-free mechanism. These agents prefer small values of k, while agents with weak preferences prefer large values of k. Together, these results suggest that the k-ticket parallel lottery performs well under most circumstances and may be suitable for other settings where items are rationed. This paper was accepted by Gabriel Weintraub, revenue management and market analytics.
Credit Shock Propagation Along Supply Chains: Evidence from the CDS Market
Authors: Agca Senay , Babich Volodymyr , Birge John R. , Wu Jing 
Published: November 2021

Using a panel of credit default swap (CDS) spreads and supply chain links, we observe that both favorable and unfavorable credit shocks propagate through supply chains in the CDS market. Particularly, the three-day cumulative abnormal CDS spread change (CASC) is 63 basis points for firms whose customers experienced a CDS up-jump event (an adverse credit shock). The value is 74 basis points if their suppliers experienced a CDS up-jump event. The corresponding three-day CASC values are –36 and –38 basis points, respectively, for firms whose customers and suppliers, respectively, experienced an extreme CDS down-jump event (a favorable credit shock). These effects are approximately twice as large for adverse credit shocks originating from natural disasters. Credit shock propagation is absent in inactive supply chains and is amplified if supply chain partners are followed by the same analysts. Industry competition and financial linkages between supply chain partners, such as trade credit and large sales exposure, amplify the shock propagation along supply chains. Strong shock propagation persists through second and third supply chain tiers for adverse shocks but attenuates for favorable shocks. This paper was accepted by Kay Giesecke, finance.
Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model
Authors: Barros-Gonçalves Tayany de D. , Saavedra Andrea F. , Silva-Couto Luzinei da , Ribeiro-Romão Raquel P. , Bezerra-Paiva Milla , Gomes-Silva Adriano , Carvalho Vinicius F. , Da-Cruz Alda Maria , Pinto Eduardo F. 
Published: November 2021

BackgroundSeveral infectious diseases are associated with hypothalamic-pituitary-adrenal (HPA) axis disorders by elevating circulating glucocorticoids (GCs), which are known to have an immunosuppressive potential. We conducted this study in golden hamsters, a suitable model for human visceral leishmaniasis (VL), to investigate the relationship ofLeishmania (L.) infantuminfection on cortisol production and VL severity.MethodsL.infantum-infected (n = 42) and uninfected hamsters (n = 30) were followed-up at 30, 120, and 180 days post-infection (dpi). Plasma cortisol was analyzed by radioimmunoassay and cytokines, inducible nitric oxide synthase (iNOS), and arginase by RT-qPCR.ResultsAll hamsters showed splenomegaly at 180 dpi. Increased parasite burden was associated with higher arginase expression and lower iNOS induction. Cortisol levels were elevated in infected animals in all-time points evaluated. Except for monocytes, all other leucocytes showed a strong negative correlation with cortisol, while transaminases were positively correlated. Immunological markers as interleukin (IL)-6, IL-1β, IL-10, and transforming growth-factor-β (TGF-β) were positively correlated to cortisol production, while interferon-γ (IFN-γ) presented a negative correlation. A network analysis showed cortisol as an important knot linking clinical status and immunological parameters.ConclusionsThese results suggest thatL.infantumincreases the systemic levels of cortisol, which showed to be associated with hematological, biochemical, and immunological parameters associated to VL severity.
Correlates of survival after autoantibody reduction therapy for acute IPF exacerbations
Authors: Kulkarni Tejaswini , Valentine Vincent G. , Fei Fei , Tran-Nguyen Thi K. , Quesada-Arias Luisa D. , Mkorombindo Takudzwa , Pham Huy P. , Simmons Sierra C. , Dsouza Kevin G. , Luckhardt Tracy , Duncan Steven R. 
Published: November 2021

Background
No medical treatment has proven efficacy for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), and this syndrome has a very high mortality. Based on data indicating humoral autoimmune processes are involved in IPF pathogenesis, we treated AE-IPF patients with an autoantibody reduction regimen of therapeutic plasma exchange, rituximab, and intravenous immunoglobulin. This study aimed to identify clinical and autoantibody determinants associated with survival after autoantibody reduction in AE-IPF.

Methods
Twenty-four(24) AE-IPF patients received the autoantibody reduction regimen. Plasma anti-epithelial autoantibody titers were determined by HEp-2 indirect immunofluorescence assays in 22 patients.

Results
Mean age of the patients was 70 + 7 years old, and 70% were male. Beneficial clinical responses that occurred early during therapy were a favorable prognostic indicator: supplemental O2 flows needed to maintain resting SaO2>92% significantly decreased and/or walk distances increased among all 10 patients who survived for at least one year. Plasma anti-HEp-2 autoantibody titers were ~-three-fold greater in survivors compared to non-survivors (p<0.02). Anti-HEp-2 titers >1:160 were present in 75% of the evaluable one-year survivors, compared to 29% of non-survivors, and 10 of 12 patients (83%) with anti-HEP-2 titers <1:160 died during the observation period (Hazard Ratio = 3.3, 95% Confidence Interval = 1.02–10.6, p = 0.047).

Conclusions
Autoantibody reduction therapy is associated with rapid reduction of supplemental oxygen requirements and/or improved ability to ambulate in many AE-IPF patients. Facile anti-epithelial autoantibody assays may help identify those most likely to benefit from these treatments.
Nutritional status and body composition in cognitively impaired older persons living alone: The Takashimadaira study
Authors: Iwasaki Masanori , Motokawa Keiko , Watanabe Yutaka , Hayakawa Misato , Mikami Yurie , Shirobe Maki , Inagaki Hiroki , Edahiro Ayako , Ohara Yuki , Hirano Hirohiko , Shinkai Shoji , Awata Shuichi 
Published: November 2021

Objectives
To investigate nutritional status and body composition in cognitively impaired older persons living alone.

Methods
This cross-sectional study included 1051 older adults (633 women and 418 men, mean age: 77.1 years) from the Takashimadaira study. The study participants were categorized according to whether they lived alone, which was confirmed via questionnaire, and had cognitive impairment, which was defined as having a Mini Mental State Examination-Japanese score ≤23. Nutritional status was evaluated using the serum albumin level. The fat-free mass index (FFMI) was calculated based on anthropometric and body composition measurements. A logistic regression model with the outcome of a low serum albumin level (serum albumin <4 g/dL) and low FFMI (<16 kg/m2 in men and <14 kg/m2 in women) were used to analyze the data.

Results
The percentages of participants in the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (-) group, the living alone (-)/cognitive impairment (+) group, and the living alone (+)/cognitive impairment (+) group were 54.8%, 37.3%, 5.6%, and 2.3%, respectively. Compared to the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (+) group was more likely to have a low serum albumin level (adjusted odds ratio = 3.10, 95% confidence interval = 1.31 to 7.33) and low FFMI (adjusted odds ratio = 2.79, 95% confidence interval = 1.10 to 7.06) after adjusting for potential confounders.

Conclusion
Cognitively impaired older adults living alone had poorer nutrition than cognitively normal and cohabitating persons in this study. Our results highlight the importance of paying extra attention to nutritional status for this group of community-dwelling older adults.
A Short Argument against Truthmaker Maximalism
Authors: Bondar Oleh 
Published: November 2021

Abstract
Mark Jago has introduced a short Fitch-style argument for truthmaker maximalism – the thesis that every truth has a truthmaker. In response to Jago, Trueman argues that the Fitch-style reasoning allows us to prove the opposite – no truth has a truthmaker. In the article, we consider the debates between Jago’s truthmaker maximalism and Trueman’s truthmaker nihilism. Also, we introduce a short Grim-style argument against Jago’s truthmaker maximalism.
Increased Connectivity among Sensory and Motor Regions during Visual and Audiovisual Speech Perception
Authors: Peelle Jonathan E. , Spehar Brent , Jones Michael S. , McConkey Sarah , Myerson Joel , Hale Sandra , Sommers Mitchell S. , Tye-Murray Nancy 
Published: November 2021

In everyday conversation, we usually process the talker's face as well as the sound of the talker's voice. Access to visual speech information is particularly useful when the auditory signal is degraded. Here, we used fMRI to monitor brain activity while adult humans (n= 60) were presented with visual-only, auditory-only, and audiovisual words. The audiovisual words were presented in quiet and in several signal-to-noise ratios. As expected, audiovisual speech perception recruited both auditory and visual cortex, with some evidence for increased recruitment of premotor cortex in some conditions (including in substantial background noise). We then investigated neural connectivity using psychophysiological interaction analysis with seed regions in both primary auditory cortex and primary visual cortex. Connectivity between auditory and visual cortices was stronger in audiovisual conditions than in unimodal conditions, including a wide network of regions in posterior temporal cortex and prefrontal cortex. In addition to whole-brain analyses, we also conducted a region-of-interest analysis on the left posterior superior temporal sulcus (pSTS), implicated in many previous studies of audiovisual speech perception. We found evidence for both activity and effective connectivity in pSTS for visual-only and audiovisual speech, although these were not significant in whole-brain analyses. Together, our results suggest a prominent role for cross-region synchronization in understanding both visual-only and audiovisual speech that complements activity in integrative brain regions like pSTS.SIGNIFICANCE STATEMENTIn everyday conversation, we usually process the talker's face as well as the sound of the talker's voice. Access to visual speech information is particularly useful when the auditory signal is hard to understand (e.g., background noise). Prior work has suggested that specialized regions of the brain may play a critical role in integrating information from visual and auditory speech. Here, we show a complementary mechanism relying on synchronized brain activity among sensory and motor regions may also play a critical role. These findings encourage reconceptualizing audiovisual integration in the context of coordinated network activity.
Prevalencia y efecto de la infección intramamaria debida a especies de estafilococos coagulasa negativo (ECN) en el conteo de células somáticas en leche de vacas Holstein en Boyacá, Colombia.
Authors: Andrade-Becerra R. J , Tarazona-Manrique L. E. , Vargas-Abella J. C. 
Published: November 2021

La mastitis es una de las enfermedades más importantes en los rebaños lecheros especializados alrededor de todo el mundo debido a los efectos sobre la producción y la salud animal. Los tipos ocasionados por estafilococos coagualasa negativo (ECN) tienen una importancia especial en una producción en la que los principales patógenos están controlados. El objetivo del presente trabajo es determinar la prevalencia del ECN en un hato lechero en Boyacá y cuantificar los efectos de cada especie de ECN en el conteo de células somáticas (CCS). Se seleccionaron 40 vacas y se tomaron muestras durante 6 meses, se realizó california mastitis test (CMT) y se tomaron muestras de los resultados desde 1 hasta donde hubo trazas. También se realizó la prueba bacteriológica de rutina para la identificación del ECN y el aislamiento del ECN se realizó mediante la identificación del gen rpoB y del tipo de cepa, usando el procedimiento de electroforesis en gel de pulso. De 960 muestras, 619 fueron positivas para el crecimiento del ECN. Las especies más prevalentes fueron Staphylococcus epidermidis, S. chromogenes, S. sciuri, S. simulans, S. haemolyticus y S. capitis. Los resultados encontrados aquí son similares a resultados en diferentes partes del mundo, lo que confirma que son patógenos que deben ser evaluados constantemente porque pueden pasar desapercibidos en los controles de rutina, especialmente en aquellas fincas donde los patógenos mayores no son un problema grave. Los resultados determinados en este estudio demuestran que el SNC genera un ligero aumento de células somáticas.
MANAJEMEN RISIKO UNIT USAHA SYARIAH BANK PEMBANGUNAN DAERAH JAMBI PADA PEMBIAYAAN MURABAHAH MODAL KERJA
Authors: Syahrizal Ahmad 
Published: November 2021

Penelitian ini dilakukan untuk mengetahui bagaimana penerapan manajemen risiko pada pembiayaan murabahah modal kerja Unit Usaha Syariah Bank Pembangunan Daerah (BPD) Jambi. Pembiayaan murabahah modal kerja memiliki risiko yang cukup besar dibandingkan pembiayaaan lainnya sehingga Unit Usaha Syariah BPD Jambi dituntut untuk menyusun, menetapkan dan menerapkan manajemen risiko yang baik. Metode yang digunakan dalam proses penelitian adalah studi empiris dengan metode kualitatif deskriptif berdasarkan data dan informasi yang didapatkan dilapangan. Berdasarkan hasil penelitian didapati bahwa dalam pembiayaan murabahah modal kerja Unit Usaha Syariah BPD Jambi telah menerapkan manajemen risiko yang cukup baik dengan adanya proses identifikasi risiko-risiko yang yang bisa saja terjadi dalam pembiayaan, adanya pengukuran risiko-risiko yang kemungkinan terjadi dengan mengamati dan membaca data serta riwayat pembiayaan calon nasabah, adanya pengelolaan dan pengendalian risiko dengan sistem tagihan, penerbitan surat peringatan serta mediasi penyelesaian permasalahan pembiayaan nasabah. Manajemen risiko yang diterapkan tergolong efektif dengan adanya peningkatan capaian pada pembiayaan murabah modal kerja tersebut.