bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Model and Nomogram Construction Based on a Novel Ferroptosis-Related Gene Signature in Lower-Grade Glioma
Authors: Zhao Junsheng , Liu Zhengtao , Zheng Xiaoping , Gao Hainv , Li Lanjuan 
Published: November 2021

Background: Low-grade glioma (LGG) is considered a fatal disease for young adults, with overall survival widely ranging from 1 to 15 years depending on histopathologic and molecular subtypes. As a novel type of programmed cell death, ferroptosis was reported to be involved in tumorigenesis and development, which has been intensively studied in recent years.Methods: For the discovery cohort, data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were used to identify the differentially expressed and prognostic ferroptosis-related genes (FRGs). The least absolute shrinkage and selection operator (LASSO) and multivariate Cox were used to establish a prognostic signature with the above-selected FRGs. Then, the signature was developed and validated in TCGA and Chinese Glioma Genome Atlas (CGGA) databases. By combining clinicopathological features and the FRG signature, a nomogram was established to predict individuals’ one-, three-, and five-year survival probability, and its predictive performance was evaluated by Harrell’s concordance index (C-index) and calibration curves. Enrichment analysis was performed to explore the signaling pathways regulated by the signature.Results: A novel risk signature contains seven FRGs that were constructed and were used to divide patients into two groups. Kaplan–Meier (K−M) survival curve and receiver-operating characteristic (ROC) curve analyses confirmed the prognostic performance of the risk model, followed by external validation based on data from the CGGA. The nomogram based on the risk signature and clinical traits was validated to perform well for predicting the survival rate of LGG. Finally, functional analysis revealed that the immune statuses were different between the two risk groups, which might help explain the underlying mechanisms of ferroptosis in LGG.Conclusion: In conclusion, this study constructed a novel and robust seven-FRG signature and established a prognostic nomogram for LGG survival prediction.
Optimization of Initial Dose Regimen for Sirolimus in Pediatric Patients With Lymphangioma
Authors: Chen Xiao , Wang Dongdong , Wang Guangfei , Huang Yidie , Yu Xin , Lu Jinmiao , Zhai Xiaowen , Xu Hong , Li Zhiping 
Published: November 2021

Sirolimus is an effective oral treatment for pediatric patients with lymphangioma. The present clinical study in 15 children (0.12–16.39 years of age) examines the effects of underlying factors on sirolimus concentrations through application of a population pharmacokinetic model. Using Monte Carlo simulation, an initial dose regimen for sirolimus in pediatric patients with lymphangioma is presented. It is found that the lower the body weight, the higher the clearance rate and sirolimus clearances are 0.31–0.17 L/h/kg in pediatric patients with lymphangioma whose weights are 5–60 kg, respectively. The doses of sirolimus, 0.07, 0.06, 0.05 mg/kg/day are recommended for weights of 5–10, 10–24.5 and 24.5–60 kg in children with lymphangioma. This study is the first to establish a population pharmacokinetic model for sirolimus and to recommend initial doses in pediatric patients with lymphangioma. Large scale, prospective studies are needed in the future.
Antihypertensive Drug Use and the Risk of Depression: A Systematic Review and Network Meta-analysis
Authors: Li Ying , Fan Yuanming , Sun Yangyang , Alolga Raphael N. , Xiao Pingxi , Ma Gaoxiang 
Published: November 2021

Background: Although numerous cohort studies have reported an association between antihypertensives use and depression, the exact effect of antihypertensives on depression remains unclear.Objective: To clarify the association between antihypertensives use and risk of depression.Methods: We retrieved relevant literature using PubMed database until August 30, 2021. Four main classes of antihypertensives, thus, angiotensin antagonists, beta blockers, calcium channel blockers and diuretics were studied. The incidence of depression was pooled based on a single drug category. Network meta-analyses were conducted to comprehensively assess the effects of the four classes of antihypertensives on the risk of depression.Results: A total of nine out of 9,557 studies involving 414,873 subjects were retrieved. The pooled results showed a positive association between the use of calcium channel blockers and symptoms of depression [odds ratio (OR): 1.09, 95% confidence interval (CI):1.06–1.13], while use of the angiotensin antagonists, beta blockers and diuretics was not associated with risk of depression. Subgroup analysis suggested a significant relationship between beta blockers usage and risk of depression in cohort studies (OR:1.21, 95% CI: 1.16–1.26). The results of network meta-analysis indicated that all other three classes of drugs increased the risk of depression: angiotensin antagonists (OR: 1.30, 95% CI: 1.04–1.63), beta blockers (OR: 1.53, 95% CI: 1.22–1.91), and calcium channel blockers (OR: 1.40, 95% CI: 1.12–1.75), compared with diuretics.Conclusion: In conclusion, our results indicate that the use of angiotensin antagonists, beta blockers and calcium channel blockers are potential risk factors of depression.
Immunological Trajectories of White Blood Cells from Adolescence to Adulthood: Description and Determinants
Authors: Barroso Isaac , Guimarães João Tiago , Severo Milton , Craveiro Vanda , Ramos Elisabete 
Published: November 2021

Background: The immune system gradually matures early in life in the face of internal and external stimuli. Whether the immune responses are lasting and stable during the course of life is still unclear. Methods: As part of the EPITeen cohort, 1183 adolescents were prospectively evaluated at the ages of 13, 17, 21, 24 and 27. Sociodemographic, behavioral and clinical data were collected by self- and face-to-face-administered questionnaires, along with a physical examination comprising anthropometric measurements and blood sample collections. Mixed-effects models were used to identify individual trajectories of white blood cells (WBC) and finite Gaussian mixture models were used to identify the clusters of individual trajectories. Results: Participants were allocated into six clusters based on the individual trajectories of WBC distribution. Higher Inflammatory Activation Cluster (11.4%) had the highest total WBC count and neutrophils percentage, as well as the lowest percentage of lymphocytes. These participants had significantly higher odds of being overweight [OR = 2.44, 95%CI:1.51–3.92]. Lowest Levels of WBC Cluster (24.1%) had the lowest total WBC count, being characterized by a higher participation on sports [OR = 1.54, 95%CI:1.12–2.13]. Highest Proportion of Eosinophils Cluster (20.1%) had the highest eosinophils percentage and the highest likelihood of having been diagnosed with a chronic disease [OR = 2.11, 95%CI:1.43–3.13], namely “asthma or allergies” [OR = 14.0 (1.73, 112.2]. Lowest Proportion of Eosinophils Cluster (29.1%) had the lowest percentage of eosinophils and basophils, as well as the highest lymphocyte proportion. Participants in the Undefined Cluster (13.8%) showed the highest percentage of monocytes and basophils and were also characterized by significant lower odds of having parents with 7–9 years of schooling [OR = 0.56, (0.32, 0.99]. Conclusions: In this study we identified distinct immunological trajectories of WBC from adolescence to adulthood that were associated with social, clinical and behavioral determinants. These results suggest that these immunological trajectories are defined early in life, being dependent on the exposures.
AGE DYNAMICS OF THE LIVE WEIGHT OF YOUNG YAKS OF THE ALTAI POPULATION
Authors: БАХТУШКИНА А.И. , САИТОВ В.Р. , САЛЬНИКОВА М.М. 
Published: November 2021

Проведено изучение интенсивности роста молодняка яков алтайской популяции, характеризующегося энергичным ростом. Динамика роста молодняка яков изучена путем определения их живой массы в разные возрастные периоды: при рождении, в возрасте 7, 12, 18 мес. По результатам взвешиваний определен абсолютный прирост, абсолютный среднесуточный прирост живой массы, относительная скорость роста. В период от рождения до 7-месячного возраста, который совпал с летним периодом пастбищного сезона, живая масса бычков увеличилась на 131,4 кг, а телок — на 120,2 кг. Интенсивность роста составила соответственно 625,7 и 572,4 г, что свидетельствует о достаточно хорошей молочности маток. В зимний период (возраст молодняка — от 7 до 12 мес) интенсивность роста резко снизилась: живая масса бычков и телочек составила всего 161,3 и 143,7 кг, со среднесуточными приростами — 94 и 58 г соответственно. С началом вегетации пастбищных растений приросты молодняка по сравнению с зимним периодом резко увеличились. В возрасте от 12 до 18 мес они были равны: 476 г — у бычков и 439 г — у телочек. Общий прирост живой массы бычков за этот период составил 86 кг, у телочек — 79 кг. Полученные данные свидетельствуют о достаточно хорошем развитии молодняка яков алтайской популяции.
The growth rate of young yaks of the Altai population, characterized by vigorous growth, was investigated. The growth dynamics of young yaks was studied by determining their live weight at different age periods – at birth and at the age of 7, 12, 18 months. According to the weighing results, the absolute gain, the absolute average daily gain in live weight, and the relative growth rate were determined. In the period from birth to 7 months of age, which coincided with the summer months of the pasture season, the live weight of bull calves increased by 131.4, and heifers — by 120.2 kg, i.e., the growth rate was 625.7 and 572.4 g, respectively, which characterizes a fairly good milk yield of cows. In the winter period (age from 7 to 12 months), the growth rate decreased sharply: the live weight of calves and calves was only 161.3 kg and 143.7 kg, with average daily gains of 94 and 58g, respectively. Subsequently, with the beginning of the growing season of pasture plants, the weight gain of young animals in comparison with the winter period increased sharply. At the age of 12 to 18 months they were equal: 476 g-for steers and 439 g-for heifers. The total increase in live weight of calves during this period was 86 kg, of heifers — 79 kg. The data obtained indicate a fairly good development of young yaks of the Altai population.
HUBUNGAN SELF MANAGEMENT DENGAN KUALITAS HIDUP PASIEN RHEUMATOID ARTHRITIS DI RUMAH SAKIT GRANDMED LUBUK PAKAM TAHUN 2021
Authors: Purba Anita Gandaria , Sitepu Kuat , Sara Arfah May , Sirait Jesiska Yolanda , Pohan Nur Hamida 
Published: November 2021

Rheumatoid arthritis is a autoimmune that causes a long period of inflammation in the joints. This might cause a deprcrease in the quality of life of a person resulting in limited activity and depression. The purpose of this study was to determine the relationship between self management and the quality of life of patients with rheumatoid arthritis . the research method uses quantitative research by using descriptive correlation research methods. Then this research uses a Cross sectional approach design research method and correlation design with a sampling total sampling, and the number of sample in this study was 25 respondents. The measuring instrument used in this research in a questionnaire. Data analysis was carried out using the chi-square tets, the result of this study showed that 18 people (51%) had a good self management and 17 people (49%) had a good quality of life. This show that there is a relationship between self managemnet and quality of life of rheumatoid arthritis patient at Grandmed Lubuk Pakam hospital in 2021 with the result of the chi-square test (p Value 0,001). Therefore, it is hoped that patients will be able to further improve self management so that the quality of life is getting better.
PENGARUH CHROMOTHERAPY TERHADAP PENURUNAN TINGKAT HALUSINASI PADA PASIEN GANGGUAN PERSEPSI SENSORI : HALUSINASI PENGLIHATAN DI RUMAH SAKIT JIWA PROF. M. ILDREM PROVINSI SUMATERA UTARA TAHUN 2021
Authors: . Pitriani , Ginting Samuel , Simarmata Juni Mariati , Jawak Efpik Fantanti 
Published: November 2021

Halusinasi merupakan gangguan persepsi sensori dari suatu obyek tanpa ada rangsangan dari luar meliputi seluruh panca indera. Chromotherapy atau terapi warna adalah terapi cahaya warna-warni dengan penyembuhan suatu penyakit pasien halusinasi. Tujuan dari penelitian untuk mengetahui pengaruh chromotherapy terhadap penurunan tingkat halusiansi penglihatan pada pasien gangguan persepsi sensori di Rumah Sakit Jiwa Prof. M. Ildrem Provinsi Sumatera Utara Tahun 2020. Metode penelitian ini bersifat eksperimen yaitu pre eksperimen rancangan menggunakan one group prepost dengan menggunakan kelompok perbandingan (control) dengan jumlah sampel 15 responden sedangkan instrumen penelitian menggunakan lembar kuesioner dan lembar observasi. Analisis data menggunakan analisi bivariat yaitu Uji Paired Sampel T-Test. Hasil penelitian hasil uji Bivariat dengan Uji Paired Sampel T-Test membuktikan bahwa ada pengaruh tindakan chromotherapy terhadap penurunan tingkat halusinasi penglihatan sebelum dan susudah tindakan dilakukan di dibuktikan dengan nilai p : 0,000 < 0,05. Kesimpulan: ada pengaruh chromotherpy terhadap penurunan tingkat halusinasi penglihatan pada pasien gangguan persepsi sensori.

Preliminary: Hallucinations are sensory perception disorders of an object without any external stimulation covering all five senses. Chromotherapy or color therapy is a colorful light therapy by healing a patient's hallucinatory disease.Aim: To find out the effect of chromotherapy on decreasing the level of vision hallucinations in sensory perception disorder patients at Prof. Mental Hospital M. Ildrem of North Sumatra Province in 2020.Method: This research is an experimental research that is pre-experimental design using one group prepost using a comparison group (control) with a sample of 15 respondents while the research instrument uses questionnaire sheets and observation sheets. Data analysis used bivariate analysis namely Paired Sample T-Test.Results: Bivariate test results with the Paired Sample T-Test Test prove that there is an effect of the chromotherapy action on the decrease in the level of hallucinations before and after the action is proven by p: 0,000 <0.05.Conclusion: there is an effect of chromotherapy on the decrease in the level of visual hallucinations in patients with sensory perception disorder
PENGARUH LEAFLET DIBANDINGKAN POWER POINT TERHADAP PENGETAHUAN DAN SIKAP IBU HAMIL TENTANG HEPATITIS B DI UPTD PUSKESMAS KEDOKAN BUNDER KABUPATEN INDRAMAYU TAHUN 2020
Authors: . Lisnawati , Purwati Sri Hani 
Published: November 2021

Introduction: Every year Hepatitis B has experienced a very rapid increase from <1% up to now reaching 5%, it is estimated that worldwide has a history of Hepatitis B and has Hepatitis B up to 2 billion people. Pregnant women have a high risk of transmitting infections around 1.5 to 2.5% of pregnant women worldwide who have Hepatitis B. Areas with the highest risk include the Mediterranean, Middle East (Gulf countries, Saudi Arabia and Turkey), Pakistan, Central, and North Asia namely Japan, Taiwan, Greenland and Africa, the Amazon basin and certain regions of the Indonesia Pacific. This study aims to determine the effect of leaflets versus power points on the knowledge and attitudes of pregnant women about Hepatitis B.
Methods: analytical research with Quasi-experiment technique with pretest and posttest Two Group Design designs taken with accidental sampling technique obtained a sample of 20 people in the leaflet group and 20 people in the powerpoint group. The instrument used was a questionnaire created by researchers who had tested the validity and reliability. The analysis used in the knowledge variable uses the Wilcoxon test and in the attitude, variable use the Mcnemar test. To know the comparison of knowledge using the Independent t-test and the attitude using the Chi-square test.
Results: the results of the independent t-test were used to find out the comparison between the leaflet group and the PowerPoint group, the p-value was 0.206, and the chi-square test between the leaflet group and the PowerPoint group obtained a p-value of 1,000.
Conclusion: there was no difference in the effect of using leaflets compared to power points on the knowledge and attitudes of pregnant women about Hepatitis B in UPTD Puskesmas Kedokan Bunder Indramayu Regency in 2020.
THE DIFFERENCE OF QUALITY OF LIFE AND COGNITIVE FUNCTION BETWEEN PATIENTS WITH AND WITHOUT AGE-RELATED MACULA DEGENERATION (AMD)
Authors: Kristianto Bobby , Sukartini Djelantik Anak Agung Ayu , Andayani Ari , Putrawati Triningrat Anak Agung Mas , Juliari I Gusti Ayu Made , Widiana I Gde Raka 
Published: November 2021

Introduction: To determine the difference in the quality of life and cognitive function in patients with and without AMD.
Methods: This research is an observational analytic study, a prospective cross sectional study in the polyclinic of RSUP Sanglah, Denpasar.
Result: Study samples’s total are 66 people selected by consecutive sampling with 33 people in the group with AMD, and 33 people in the group without AMD. The results of the study showed the average age of the group with AMD 68 years and the group without AMD 67 years old. Most of the male sex and residence in denpasar in both groups. Most AMD with the wet type by 60.6 %. On the measurement of quality of life, it showed decreasing in all subscale in the group with AMD compared to the group without AMD with total average 27.2 % and also decreasing in cognitive function measured by MMSE in the group of AMD compared to the group of non – AMD with 6.8%, even though the MMSE score of the groups are within normal limits. All these things stated significant differences (p<0.05) statistically.
Conclusion: There are decreasing quality of life and cognitive function in AMD groupd compared to Non-AMD group which is needed more treatment and screening in the future.
Progress in high crystalline quality AlN grown on sapphire for high-efficiency deep ultraviolet light-emitting diodes
Authors: Xu F. J. , Shen B. 
Published: November 2021

Abstract
AlGaN with a high Al fraction and low-dimensional structure is an important material for deep ultraviolet (DUV) optoelectronic devices. However, due to a lack of high-quality and low-cost homogeneous AlN substrates, AlN is mainly prepared by heteroepitaxy on sapphire with a large lattice mismatch. The resulting defect density and residual stress in AlN films become a bottleneck for enhancing the performance of AlGaN-based DUV light-emitting devices. In this paper, the research advances in epitaxial growth and threading dislocation (TD) control of AlN on sapphire substrates at Peking University are described, including decreasing the tilt of AlN grains by nitridation pretreatment of sapphire, forming TD loops by growth mode alternations, bending and terminating TDs at the sidewall of voids by an image force on nano-patterned sapphire substrates, promoting the climbing and meeting of TDs by extrinsic supersaturated vacancies, etc. Based on high-quality AlN with a TD density of ∼108 cm−2, 276 nm DUV light-emitting diodes are fabricated with a light output power of 17.3 mW at an injection current of 100 mA.
PENERAPAN METODE CLUSTERING PADA ANALISIS REALISASI PENDAPATAN ASLI DAERAH DENGAN ALGORITMA K-MEANS
Authors: Apuilino Iman Seno Aji Farell , Achmadi Sentot , Ariwibisono FX 
Published: November 2021

Retribusi Daerah adalah pungutan daerah sebagai pembayaran atas jasa atau pemberian izin tertentu yang khusus disediakan dan atau diberikan oleh Pemerintah Daerah untuk kepentingan orang pribadi atau badan menurut UU No. 28 tahun 2009. Pemasukan Pajak Daerah dan Retribusi Daerah tersebut lalu dikumpulkan oleh para Pejabat Pajak untuk digolongkan serta dianalisis. Dalam proses tersebut, data retribusi pendapatan asli daerah yang masuk akan diinputkan ke dalam Microsoft Excel, sehingga saat dilakukan penganalisisan serta pengelompokan secara manual menggunakan Microsoft Excel, menjadi tidak efektif karena data yang diolah sangat banyak sehingga menyebabkan tampilan sedikit membingungkan dan rawan terhadap kesalahan input pada proses perhitungan. Selain memakan waktu untuk melakukan perhitungan, terjadinya kesalahan perhitungan dapat mengakibatkan terjadinya kesalahan analisis oleh para Pegawai Pajak
Pada penelitian ini, akan dibuat sebuah sistem berbasis web dengan menggunakan metode K-Means, yang dapat membantu Pegawai Pajak dalam menganalisis dan juga pengelompokan hasil pemasukan seluruh retribusi PAD. Sehingga sebanyak apapun data yang diinputkan, hasil perhituungan diharapkan akan konsisten sesuai dengan metode K-Means dan kesalahan perhitungan dapat diminimalisir karena perhitungan telah dilakukan secara otomatis. Dalam proses analisis dan penggolongan data retribusi pendapatan asli daerah, perhitungan dilakukan berdasarkan kriteria yang telah ditentukan oleh instansi terkait, Kriteria - kriteria tersebut nantinya akan diproses dengan perhitungan metode K-Means berbasis web yang menggunakan framework Laravel dan bahasa pemograman PHP (Hypertext Preprocessor) dengan Database MySQL.
Hasil dari pengujian metode pada 115 data yang telah diuji dengan sistem ini, sebanyak 37 data masuk kedalam cluster C8 sebagai golongan restoran dan juga 31 data masuk kedalam cluster C7 sebagai golongan cafe, yang artinya pemasukan pajak restoran dan café memiliki pengaruh yang cukup besar dalam retribusi pendapatan asli daerah di Kabupaten Gresik. Dari hasil perhitungan antara manual menggunakan Ms. Excel dibandingkan perhitungan di sistem yang telah dibuat memiliki rata – rata error sebesar 0.32% dengan tingkat keakuratan sebesar 99.68%. Berdasarkan hasil pengujian fungsional menunjukkan jika sistem yang telah dibuat dapat berjalan dengan baik dan sesuai dengan fungsi yang tersedia. Sistem yang telah dibuat diuji coba dengan menggunakan 3 aplikasi browser yaitu Microsft Edge 91.0.864.54 (Official build) (64-bit), Google Chrome 91.0.4472.114 (Official Build) (64-bit) dan Mozilla Firefox 89.0.1 (64-bit).