bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 3-Mb High-Resolution BAC/PAC Contig of 12q22 Encompassing the 830-kb Consensus Minimal Deletion in Male Germ Cell Tumors
Authors: Murty Vundavalli V.V.S. , Montgomery Kate , Dutta Shipra , Bala Shashi , Renault Beatrice , Bosl George J. , Kucherlapati Raju , Chaganti Raju S.K. 
Published: November 2021

Cytogenetic and molecular genetic analyses have shown that the 12q22 region is recurrently deleted in male germ cell tumors (GCTs), suggesting that this site may harbor a tumor suppressor gene (TSG). Previous loss of heterozygosity (LOH) analyses identified a consensus minimal deleted region between the markers D12S377 andD12S296, and a YAC clone contig covering the region was generated. Here, we describe a high-resolution sequence-ready physical map of this contig covering a 3-Mb region. The map comprised of 52 cosmids, 49 PACs, and 168 BACs that were anchored to the previous YAC contig; 99 polymorphic, nonpolymorphic, EST, and gene-based markers are now placed on this map in a unique order. Of these, 61 markers were isolated in the present study, including one that was polymorphic. In addition, we have narrowed the minimal deletion to ∼830 kb betweenD12S1716 (proximal) and P382A8-AG (distal) by LOH analysis of 108 normal-tumor DNAs from GCT patients using 21 polymorphic STSs. These physical and deletion maps should prove useful for identification of the candidate TSG in GCTs, provide framework to generate complete DNA sequence, and ultimately generate a gene map of this segment of the chromosome 12.[The sequence data described in this paper have been submitted to the Genome Survey Sequence under accession nos. AQ254896–AQ254955 andAQ269251–AQ269266. Online supplementary material is available athttp://www.genome.org]
A Sequence-Ready BAC Contig of the GABAA Receptor Gene Cluster Gabrg1–Gabra2–Gabrb1 on Mouse Chromosome 5
Authors: Lengeling Andreas , Wiltshire Tim , Otmani Chris , Bućan Maja 
Published: November 2021

The type-A receptors for the neurotransmitter GABA (γ-aminobutyric acid) are ligand-gated chloride channels that mediate postsynaptic inhibition. The functional diversity of these receptors comes from the use of a large repertoire of subunits encoded by separate genes, as well as from differences in subunit composition of individual receptors. In mammals, a majority of GABAAreceptor subunit genes are located in gene clusters that may be important for their regulated expression and function. We have established a high-resolution physical map of the cluster of genes encoding GABAA receptor subunits α2 (Gabra2), β1 (Gabrb1), and γ1 (Gabrg1) on mouse chromosome 5. Rat cDNA probes and specific sequence probes for all three GABAA receptor subunit genes have been used to initiate the construction of a sequence-ready contig of bacterial artificial chromosomes (BACs) encompassing this cluster. In the process of contig construction clones from 129/Sv and C57BL/6J BAC libraries were isolated. The assembled 1.3-Mb contig, consisting of 45 BACs, gives five- to sixfold coverage over the gene cluster and provides an average resolution of one marker every 32 kb. A number of BAC insert ends were sequenced, generating 30 new sequence tag sites (STS) in addition to 6 Gabr gene-based and 3 expressed sequence tag (EST)-based markers. STSs from, and surrounding, theGabrg1–Gabra2–Gabrb1 gene cluster were mapped in the T31 mouse radiation hybrid panel. The integration of the BAC contig with a map of loci ordered by radiation hybrid mapping suggested the most likely genomic orientation of this cluster on mouse chromosome 5: cen–D5Mit151–Gabrg1–Gabra2–Gabrb1–D5Mit58–tel. This established contig will serve as a template for genomic sequencing and for functional analysis of the GABAA gene cluster on mouse chromosome 5 and the corresponding region on human chromosome 4.The sequence data described in this paper have been submitted to the GenBank/GSS data libraries under accession nos.AF156490 and AQ589406–AQ589436.
Evidence Suggesting That a Fifth of Annotated Caenorhabditis elegans Genes May Be Pseudogenes
Authors: Mounsey Andrew , Bauer Petra , Hope Ian A. 
Published: November 2021

Only a minority of the genes, identified in theCaenorhabditis elegans genome sequence data by computer analysis, have been characterized experimentally. We attempted to determine the expression patterns for a random sample of the annotated genes using reporter gene fusions. A low success rate was obtained for evolutionarily recently duplicated genes. Analysis of the data suggests that this is not due to conditional or low-level expression. The remaining explanation is that most of the annotated genes in the recently duplicated category are pseudogenes, a proportion corresponding to 20% of all of the annotated C. elegansgenes. Further support for this surprisingly high figure was sought by comparing sequences for families of recently duplicated C. elegans genes. Although only a preliminary analysis, clear evidence for a gene having been recently inactivated by genetic drift was found for many genes in the recently duplicated category. At least 4% of the annotated C. elegans genes can be recognized as pseudogenes simply from closer inspection of the sequence data. Lessons learned in identifying pseudogenes in C. elegans could be of value in the annotation of the genomes of other species where, although there may be fewer pseudogenes, they may be harder to detect.[Online supplementary material available atwww.genome.org.]
Impact of AI technologies on organisational learning: proposing an organisation cognition schema
Authors: Nimmi P.M. , Vilone Giulia , Jagathyraj V.P. 
Published: November 2021

Purpose
The work depicts an organizational learning schema, which reflects on the cognition structure of workplaces during the integration of AI-powered technologies.

Design/methodology/approach
This paper summarizes the most recent advances on organizational cognition from organizational studies. The article tries to capture how learning is impacted at the individual level and organization level, with incorporation of AI technologies.

Findings
The theoretical schema on organizational cognition could be studied and integrated to fill this gap and support an effective and smooth transition from electronic, computer-based industries (characteristics of the third industrial revolution) to AI powered enterprises.

Originality/value
It's one of the first works to discuss organization learning along with AI technologies.
The impact of the COVID-19 pandemic and policy response on single-parent families in Malaysia
Authors: Rahman Nur Hairani Abd 
Published: November 2021

PurposeThe study focuses on the impact of the coronavirus disease 2019 (COVID-19) pandemic and policy measures implemented by the Malaysian government to address issues during this period. The study examines the impacts on the financial security and mental health of single-parent families in Malaysia.Design/methodology/approachThe study used a cross-sectional survey to obtain data about single-parent families. To support the information collected with the survey, interviews were conducted with six representatives from six single-parent associations.FindingsThe study identified that policy measures implemented by the Malaysian government have helped improve the financial security of single-parent families. However, for mental health, the support single parents received was not able to provide better quality of life, as the majority were severely affected by the COVID-19 pandemic, especially during lockdown, before they received any assistance from the government.Research limitations/implicationsThe study was conducted during the pandemic; thus, the study was not able to include a larger sample of single parents. Therefore, the findings cannot be generalized to explain nationwide issues. However, the study provides important insights into understanding the effect of the COVID-19 pandemic on people, especially single-parent families.Practical implicationsThe study confirmed that the COVID-19 pandemic has affected single parents in different ways. Financial security and mental health, the focus of this study, have provided a clear justification for how pandemics could affect people’s lives. Specifically, the situation was exacerbated after the implementation of movement control orders in Malaysia, and it has continuously affected the living conditions of single-parent families.Social implicationsThe study focuses on single-parent families, a group that receives less attention from the government and policies, although this group is recognized as one of the vulnerable groups. Understanding this context helps to provide a clear guide for how policies can be formulated and provides equal attention to assist this group in the future.Originality/valueThis study focuses on single-parent families. Few studies have examined this perspective using Malaysia as the study context. Moreover, the study analyzes the pandemic situation, and this area is still new and underexplored.
Community norms and corporate philanthropy: the moderating role of women on board of directors
Authors: Wang Xin , Zhang Zhe , Jia Ming 
Published: November 2021

PurposeThis study examines how community norms, such as religious atmosphere and economic pressures, affect corporate philanthropic giving. Grounded in upper echelon theory, the authors further focus on how the women on board of directors (BODs) play an important role in the relationship between community norms and corporate philanthropic giving.Design/methodology/approachThis study utilizes a two-stage Heckman selection model to control the sample-selection bias. The final sample includes 8,566 observations for the first stage and 5,575 observations for the second stage. Then, by using a sample of Chinese listed firms in 2010–2014, this study establishes a strong and robust support for the hypotheses.FindingsThis study finds that religious atmosphere is significantly and positively associated with corporate philanthropic giving, whereas the relationship between economic pressure and corporate philanthropy is negative. Furthermore, women on BODs not only strengthen the relationship between religious atmosphere and corporate philanthropic giving but also strengthen the relationship between economic pressure and corporate philanthropic giving.Originality/valueFirst, the authors contribute to community literature by developing a subdivided perspective. The authors provide the first attempt to empirically investigate the hidden association between the two perspectives of community (religious atmosphere and economic pressure) and corporate philanthropic giving. Second, the authors contribute to the literature on corporate philanthropy by expanding the antecedents of corporate philanthropic giving to communities where firms are headquartered. Third, by capturing the multiple identities of women, the authors enrich the study of the influence of minority groups on corporate decision-making. The authors find that gender diversity on BODs strengthen the influence of community norms on corporate philanthropic giving.
Job satisfaction and OCBs: what’s new? The mediating role of organizational identification
Authors: Urbini Flavio , Chirumbolo Antonio , Caracuzzo Emanuela , Callea Antonino 
Published: November 2021

Purpose
The purpose of this paper is to investigate the effects of intrinsic job satisfaction (JS) on organizational citizenship behaviors (OCBs) directed toward individuals (OCBs-I) and OCB directed toward organization (OCBs-O) via organizational identification (OID). Based on social exchange and social identity theories, it is hypothesized that OID may play a mediator role in the relationship between JS and OCBs-I and OCBs-O.

Design/methodology/approach
A questionnaire investigating JS, OID and OCBs dimensions was administered to 719 Italian employees. The mediation hypotheses were analyzed through structural equation model, via bootstrap analysis, after preliminary analyses as correlations and measurement model.

Findings
Results showed a positive relationship between JS, OID and OCBs dimensions. Furthermore, OID partially mediated the positive effects of JS on OCBs-I and OCBs-O. These findings supported hypotheses, suggesting that OID may explain the psychological mechanism through which an employee intrinsically satisfied about own job will fulfill more extra-role performance, i.e. OCBs-I and OCBs-O.

Practical implications
Implications for human resource management policies are discussed: to HR professionals is proposed to implement interventions to enhance employees’ intrinsic satisfaction and identification with the organization, to increase consequently positive organizational behaviors such as OCBs.

Originality/value
This study attempted to examine the JS-OCBs relationship in more depth. For the first time, the JS on OCBs-I and OCBs-O were simultaneously investigated, with OID as a mediator: shedding new light on the relationship among these variables.
Orchestrating value co-creation in online communities as fluid organisations: firm roles and value creation mechanisms
Authors: Priharsari Diah , Abedin Babak 
Published: November 2021

PurposeThe lack of authority of the sponsoring firm in online communities raises questions about how to orchestrate members of an online community in value co-creation. Hence, this study aims to examine how online communities co-create value with community members. The authors draw upon service-dominant logic (SDL) to study two comparable, and yet different, Indonesian firm-sponsored online communities.Design/methodology/approachThe authors build on an earlier systematic literature review and triangulate it with semi-structured interviews of 28 community members and content analysis of over 35,000 online comments. The data collection was conducted from February to October 2018.FindingsThe findings revealed that (1) value co-creation in online communities is orchestrated through the fluidity of the online community, which is represented by three mechanisms: consensus-making, consensus settlement and changing boundaries, and (2) the mechanisms can be conditioned by switching firm roles (as a co-creator and facilitator).Research limitations/implicationsThe study has enriched the body of knowledge in fluid organisations by explicating three mechanisms, consensus-making, consensus settlement and changing boundaries, that explain the coordination efforts between individuals who have options to participate or not and changing boundaries, that reveals actors' responses in online communities. The mechanisms demonstrate the dynamics of a service ecosystem.Originality/valueThis study offers valuable insights into how sponsoring firms orchestrate value creation in online communities where they do not have full control of participants' reactions. The authors hereby contribute to enriching the understanding of co-creating value with customers in a fluid organisation, such as online communities.
Leading change in health care: the challenge of anxiety
Authors: Edmonstone John Duncan 
Published: November 2021

Purpose
The purpose of this paper is to identify the centrality of anxiety in health care, especially in the context of leading change. It identifies the importance of emotional labour for clinical professionals and the resultant development of defensive routines. The idea of containment is central to addressing anxiety.

Design/methodology/approach
The approach involves identification of anxiety as a key factor in leading change in health care, but one which is often ignored.

Findings
Anxiety is the elephant in the room vis-a-vis leading change in health care. To address the use of defensive routines, a range of activities can act as “containers” for anxiety and help with leading change.

Practical implications
To lead change in health care implies addressing the existence and importance of anxiety and the emotional labour which health-care professionals undertake.

Originality/value
The existence of anxiety and the profound impact it has on leading change in health care has typically been under-estimated or avoided. The paper aims to remedy this.
Physical activity and sedentary behaviors associated with overweight and obesity among primary school children in Tanzania: a case-control study
Authors: Pacific Renatha , Kulwa Kissa , Martin Haikael D. , Petrucka Pammla 
Published: November 2021

Purpose
This study aims at determining the risk of physical inactivity and sedentary behaviors on overweight and obesity among primary school children aged 10–13 years in Tanzania.

Design/methodology/approach
A case-control study was conducted from January to March 2020 involving 69 overweight/obese children as cases and 138 normal weight children as controls. Cases were identified as having body mass index-for-age ≥ +1 standard deviation (SD) and controls as those having BMI-for-age range between −2 SD to <+1 SD. A validated questionnaire was used for data collection on daily physical activities and sedentary behavior types, frequency duration and activity score. An independent sample t-test was used to compare means of activity score between cases and controls. Binary logistic regression was used to predict risk factors for overweight/obesity.

Findings
Risk factors for overweight/obesity were listening to music and/or radio for >2 h/week (OR 2.7, 95% CI 1.2–6.1) and walking for exercise <2 h/week (OR 2.1, 95% confidence interval [CI] 1.1–4.1). On the other hand, rope skipping for >2 h/week (OR 0.14, 95% CI 0.03–0.7) was a protective factor against overweight/obesity. Controls had a significantly higher mean score of being active during lunch breaks compared to cases (p = 0.012). Cases had higher weight, height and percentage body fat than controls (p < 0.001). The home environment provided more avenues for physical activity than the school environment.

Originality/value
To the best of the authors’ knowledge, this is original research work and the first case-control study to predict physical activity and sedentary behaviors as risk factors for overweight and obesity in Tanzanian school children.
Organizational workplace relocation: assessment of facilities and real estate managers' practices
Authors: Ibrahim Ahmed M. , Hassanain Mohammad A. 
Published: November 2021

PurposeThis research investigates the literature and perspectives of bilateral domains of experts, the facilities management (FM) and real estate management (REM) professionals. It provides insights towards a comprehensive understanding of office facilities relocation as organizational workplaces.Design/methodology/approachAn investigation of the literature was conducted, to identify design aspects, drivers, challenges, and technical and functional considerations of the workplace relocation. A structured survey was utilized, as face-to-face interviews with 32 FM and 32 REM professionals, to explore and compare their perspectives and expertise.FindingsThe study identified key aspects for workplace relocation that were rarely focused on, holistically, in the literature. The research led to identifying the drivers, challenges, considerations, scenarios, and design needs pertaining to the implementation, acquisition, and occupation of the workplace in times of relocation. There is a dispersed view on workplace relocation between FM and REM, which requires alignment. FM and REM experts' perspectives were intrinsically discussed to ascertain the identified key areas.Practical implicationsWorkplace relocation is a change that disturbs almost every workplace around the globe, at least once in its life cycle. This study enlists comprehension of the knowledge obtained from a review of the international literature, to provide a holistic guide for organizational decision makers, and interlink FM and REM professionals' perspectives, for enhanced decision-making.Originality/valueThis article reviews the literature on workplace relocation, covering FM and REM domains perspectives to advance the organizational workplace relocation practices.
Rooftop photovoltaic system allocation to improve the distribution transformers life span using golden ratio optimization algorithm
Authors: Sobouti Mohammad Amin , Bigdeli Mehdi , Azizian Davood 
Published: November 2021

Purpose
This paper aims to evaluate the effect of optimal use of rooftop photovoltaic (PV) systems on improving the loss of life (LOL) of distribution transformers, reducing power losses as well as the unbalance rate of the 69-bus distribution network.

Design/methodology/approach
The problem is studied in three scenarios, considering different objective functions as multi-objective optimization in balanced and unbalanced operations. Meta-heuristic golden ratio optimization method (GROM) is used to determine the optimal size of the rooftop PV in the network.

Findings
The simulation results show that in all scenarios, the GROM by optimally installing the rooftop PV is significantly capable to reduce the transformer distribution loss of loss, unbalance rate and power loss as well as reduce the temperature of the oil and transformer winding. Also, the lowest %LOL, power loss and unbalance rate occurred in the second scenario for the balanced network and first scenario, respectively. In addition, the results showed that the unbalance of the network results in increased power losses and LOL of the distribution transformer.

Originality/value
The better capability of GROM is proved compared with the grey wolf optimization algorithm with better objective function and by achieving better values of LOL, unbalance rate and power loss. The results also showed that the %LOL, unbalance and power losses are weakened compared to without considering the PV cost but the achieved results are realistic and cost-effective.
Forgetting Oneself: Epigraphs and Escapism in Ann Radcliffe's Novels
Authors: Yem Eirian Jade 
Published: November 2021

AbstractIn spite of its gendered heritage, Ann Radcliffe was an early adopter of the chapter epigraph. She wrote her fiction with the interests of a growing female readership in mind, placing English (as opposed to Latin or Greek) epigraphs at the head of her chapters and quoting women alongside men. This article uses two of her novels, The Romance of the Forest (1791) and The Mysteries of Udolpho (1794), to explore the concept of forgetting oneself and the role of the epigraph in correcting a feminine mode of reading associated with the Gothic novel. It argues for the epigraph as a conservative but democratic form, which allowed Radcliffe to stage issues of nationalism and gender politics, and reveals an ambivalence towards authority that is characteristic of Radcliffe's style and purpose.