bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Unconfined Compressive Strength of Microfine Cement Injected Sands Using Fuzzy Logic Method
Authors: Yildirim Eray , Avci Eyubhan , Tanbay Nurten Akgün 
Published: November 2021

Abstract
In this study, unconfined compressive strength values of sand soil injected with microfine cement were predicted using fuzzy logic method. Mamdani and Sugeno methods were applied in the fuzzy logic models. In addition, a regression analysis was carried out in order to compare these two methods. In the models, water/cement ratio and injection pressure were the input variables, and unconfined compressive strength was the output variable. The dataset includes 427 samples, which were experimentally injected with microfine cement. Predictions for unconfined compressive strength were obtained by creating membership functions and rule base for each input (predictive) parameter in fuzzy logic models. The coefficient of determination (R2) and Mean Square Error (MSE) were used as criteria for evaluating the performance of the developed models. The results suggested that the three applied models (i.e. Mamdani, Sugeno and regression) provided statistically significant results, and these methods could be used in the future prediction-based studies. The results showed that Sugeno model provided the best performance for predicting unconfined compressive strength. It was followed by Mamdani and Regression models, respectively. This study has suggested that the fuzzy logic method can be an alternative to the regression method which traditionally has been used in prediction process.
Deep Learning Based Models: Basic LSTM, Bi LSTM, Stacked LSTM, CNN LSTM and Conv LSTM to Forecast Agricultural Commodities Prices
Authors: Murugesan R. , Mishra Eva , Krishnan Akash Hari 
Published: November 2021

Abstract
The literature argues that an accurate price prediction of agricultural goods is a quintessence to assure a good functioning of the economy all over the world. Research reveals that studies with application of deep learning in the tasks of agricultural price forecast on short historical agricultural prices data are very scarce and insist on the use of different methods of deep learning to predict and to this reaction of filling the gap, this study employs five versions of LSTM deep learning techniques for the task of five agricultural commodities prices prediction on univariate time series dataset of Rice, Wheat, Gram, Banana, and Groundnut spanning January 2000 to July 2020. The study obtained good forecasting results for all five commodities employing all the five LSTM models. The study validated the results with lower values of error metrics, MAE, MAPE, MSE, and RMSE and two paired t-test with hypothesis and confidence level of 95% as a measure of robustness. The study predicted the one month ahead future price for all the five commodities and compared it with actual prices using said LSTM models and obtained promising results.
Comparing Two Types of Endometrial Scratch Before Embryo Transfer: A Prospective Randomized Pilot Study
Authors: Goldrick Kathryn M , Marshburn Paul B , Matthews Michelle L , Usadi Rebecca S , Papadakis Margaret A , Hurst Bradley S 
Published: November 2021

Abstract
Purpose: Although endometrial scratch may improve outcomes in certain groups of women undergoing assisted reproductive technology (ART), the type of endometrial procedure has not been specified. Our objective was to determine if two types of endometrial scratch prior to embryo transfer result in similar implantation and live birth rates. Also, to determine if patients experience similar pain from both types of endometrial scratch.Methods: This was a prospective, non-blinded, randomized controlled trial with parallel treatment arms of women undergoing blastocyst embryo transfer. Patients underwent endometrial scratch with either vigorous Pipelle curette or four-quadrant scratch with the Shepard insemination catheter.Results: There were 78 patients in the Pipelle curette group and 92 in the Shepard catheter group. There was no difference in implantation rates for the two groups (56.5% ±48 for Pipelle curette group vs. 59.7%±52 for Shepard catheter group, p-value 0.9). Live birth rates were also similar for the two groups (48.1% ±50 for Pipelle curette group vs. 46.8%±50 for Shepard catheter group, p-value 0.7). Mean pain score was significantly less for the Shepard catheter group than for the Pipelle curette group (3.0±2.4 vs. 3.9±2.2, p-value 0.01).Conclusions: Our study demonstrates no difference in implantation or live birth rates for two types of endometrial scratch. There was a difference in patient pain scales with endometrial scratch by a Shepard insemination catheter having a significantly lower pain score than by Pipelle curette. This data gives guidance as to the type of endometrial scratch to be performed prior to ART.
High frequency plant regeneration of Chrysopogon zizanioides via organogenesis and somatic embryogenesis-an underutilized pharmaceutically valuable biofuel plant
Authors: Monisha M. Merlin , Prakash M. , Saravanan K.R. , R Anandan 
Published: November 2021

Abstract
Vetiver (Chrysopogon zizanioides) is an essential oil-producing plant that has tremendous application in cosmetics, perfumery, and herbal medicine. Natural sterility and indiscriminate harvests lead to the risk of extinction of plant species in natural habitats. Therefore, a protocol for regeneration systems via organogenesis and somatic embryogenesis using node, leaf, and root explants has been standardized. The highest shoot regeneration frequency (72.2%) through organogenesis was attained from node explants on MS (Murashige & Skoog) medium comprising 2.0 mg L-1 BAP (“6-benzylaminopurine”). Concurrently, leaf explants cultivated on MS medium augmented by 1.0 mg L-1, 2, 4-D (“2, 4-dichlorophenoxyacetic acid”) formed the optimal frequency (75.35%) of white friable compact (WFC) callus. However, the root explant was less responsive for WFC callus induction. Organogenic WFC callus cultivated on MS medium fortified by kinetin (1.0 mg L-1) as well as BAP (1.0 mg L-1) revealed the highest shoot regeneration efficiency (75.49%) with 48 shoots per callus. Adventitious shoots obtained from node and WFC callus of both leaf and root explants cultivated on MS medium increased by NAA (2.0 mg L-1 showed the optimal rooting of 76.97%. Concomitantly, an elevated frequency of somatic embryogenesis (52.50%) was recorded from leaf explants on MS medium using BAP (0.5 mg L-1) & 2, 4-D (1.0 mg L-1). Leaf explants were superior to node and root explants for somatic embryo initiation. The cotyledonary embryos were efficiently germinated into complete plantlets on a hormone-free MS medium. The plantlets gathered from organogenesis & somatic embryo genesis was effectively acclimatized into phenomenally similar plants. This technique may be applicable for wide-range propagation, genetic engineering, and the formation of bioactive compounds.
Rituximab in Combination with Gemcitabine Plus Cisplatin in Patients with Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma: A Phase I Trial
Authors: Hsieh Ching-Yun , Lien Ming-Yu , Lin Chen-Yuan , Lo Wen-Jyi , Hua Chung-Hung , Chang Wei-Chao , Chiu Chang-Fang , Lin Ching-Chan 
Published: November 2021

Abstract
BackgroundThe treatment of recurrent or metastatic head and neck squamous-cell carcinoma (R/M HNSCC) remains challenging. Preclinical studies revealed that B cell depletion could modulate the microenvironment and overcome chemoresistance. We conducted a phase I study to evaluate the feasibility and safety of B cell depletion using the anti-CD20 antibody rituximab to treat HNSCC.MethodsTen patients were enrolled into two protocols. The first four patients treated using protocol 1 received rituximab 1000 mg on days −14 and −7, followed by gemcitabine/cisplatin every 3 weeks, and rituximab was administered every 6 months thereafter. Because of disease hyperprogression, protocol 1 was amended to protocol 2, which consisted of the concomitant administration of rituximab 375 mg/m2 and gemcitabine/cisplatin every 3 weeks. Another six patients were enrolled and treated using protocol 2.ResultsThree patients treated using protocol 1 exhibited rapid disease progression, and the remaining patient could not undergo evaluation after rituximab treatment. Conversely, no unpredicted harm was observed in the six patients treated using protocol 2. Among these patients, one achieved complete response, and two had partial responses. The disease-free durations in these patients were 7.0, 6.2, and 7.1 months, respectively. Immune cell analysis revealed a higher ratio of cytotoxic T cells to regulatory T cells in responders than in non-responders.ConclusionsB cell depletion using rituximab alone in patients with HNSCC can cause hyperprogressive disease. Contrarily, the co-administration of rituximab and cisplatin/gemcitabine was feasible and safe.Trial registration:ClinicalTrials.gov Identifier: NCT04361409, 24/April/2020, retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT04361409
Dual-modal Assessment for in Vivo Investigation of Neurovascular Characteristic of Cerebral Edema Induced by Lipopolysaccharide
Authors: Li Weitao , Zhang Yameng , Xie Qian , Yang Yamin , Yao Liuye , Ning Xue , Qian zhiyu 
Published: November 2021

Abstract
The pathological features of cerebral edema are complicated, but usually only intracranial pressure (ICP) is regarded as the most important indicator for monitoring cerebral edema. The research focused on investigating the neurovascular characteristic of the lipopolysaccharide (LPS)-induced cerebral edema model in rats by using simultaneous electrophysical and hemodynamic recording. The results showed that neurophysiology (firing rate (FR), interval histogram index (ISI), and the power spectrum of local field potential (LFPs power)) and hemodynamic response (oxygenated hemoglobin (HbO2), deoxyhemoglobin (HbR) and relative cerebral blood flow (CBF)) were linearly related, and the Pearson’s correlation coefficient was determined by the BBB integrity after LPS injection. Furtherly, the improvement of treatment after two agents were observed successfully through these neurophysiological and hemodynamic parameters. The optical-electrical joint method provided a technical solution for cerebral edema functional monitoring and anti-edema drug efficacy evaluation. Our findings revealed the neurovascular and BBB impact of cerebral edema and improved the limitation of in vivo pathological diagnosis of cerebral edema.
Experimental Research On the Performance of a Novel Geo-Filament Anchor For An Earthen Architectural Site
Authors: Yulan Wang , Jian Guo , Weixi Zhang , Fan Lei 
Published: November 2021

Abstract
An efficient anchoring method, explicitly developed for small sliders, has hitherto been missing in the practice of earthen architecture conservation. Furthermore, anchoring performance studies conducted so far, have failed to fully take into account the soil characteristics of certain targets. To address these concerns, the conservation project conceived for the Gaochang Ruins, Turpan, in China, was selected as the testing ground to design a novel Geotechnical Filament Anchor (GFA) for reinforcing small sliders in the earthen historical ramparts. In-situ experiments were conducted for evaluating six parameters—anchoring length (L), GF thickness (H), bore diameter (D), grouting strength (S), GFA surface status (R), and inclination angle (A). These parameters were varied in order to determine the effect they produce on anchoring performance, as demonstrated by the indicators, including tensile strength, destruction mode, load displacement (P-S) relation, and strain (ζ-L) distribution characteristics of the novel GFA. Data acquired from the experiments, in combination with the conservation specifics of earthen architectural sites, anchoring performance, and safety reserve, were further employed to introduce a calculation formula for computing the designed force value (N) through L. A simplified model depicting the shear stress distribution of the anchoring system under N was devised by extracting the strain distribution data with respect to the GF-grouting interface. Taking into account the soil properties of the above-mentioned site, the shear stress diffusion coefficient (α) was conceptualized, the formula for the shear strength of the grouting material was devised, and the tolerable ranges of L, D, H, R, and S were determined. Thus, a feasible anchoring method for small sliders used in earthen architectural sites is proposed, and validated by strong and reliable experimental and theoretical groundwork.
Observation of optical gyromagnetic properties in a magneto-plasmonic metamaterial
Authors: Yang Weihao , Liu Qing , Wang Hanbin , Chen Yiqin , Yang Run , Xia Shuang , Luo Yi , Deng Longjiang , Qin Jun , Duan Huigao , Bi Lei 
Published: November 2021

Abstract
Metamaterials with artificial optical properties have attracted significant research interest. In particular, artificial magnetic resonances in non-unity permeability tensor at optical frequencies in metamaterials have been reported. However, only non-unity diagonal elements of the permeability tensor have been demonstrated to date. A gyromagnetic permeability tensor with non-zero off-diagonal elements has not been observed at the optical frequencies. Here we report the observation of gyromagnetic properties in the near-infrared wavelength range in a magneto-plasmonic metamaterial. The non-zero off-diagonal permeability tensor element causes the transverse magneto-optical Kerr effect (TMOKE) under s-polarized incidence that otherwise vanishes if the permeability tensor is not gyromagnetic. By retrieving the permeability tensor elements from reflection, transmission, and TMOKE spectra, we show that the effective off-diagonal permeability tensor elements reach the 10-3 level at the resonance wavelength (~900 nm) of the split-ring resonators that is at least two orders of magnitude higher than that of magneto-optical materials at the same wavelength. The artificial gyromagnetic permeability is attributed to the change in the local electric field direction modulated by the split-ring resonators. Our study demonstrates the possibility of engineering the permeability and permittivity tensors in metamaterials at arbitrary frequencies, thereby promising a variety of applications of next-generation nonreciprocal photonic devices, magneto-plasmonic sensors, and active metamaterials.
Realtalk Evidence-Based Communication Training: Development of a Conversation Analysis-Based Intervention Designed to be Delivered by Clinical Trainers
Authors: Parry Ruth , Whittaker Becky , Pino Marco , Jenkins Laura , Worthington Esme , Faull Christina 
Published: November 2021

Abstract
BACKGROUNDCommunication skills training for professionals caring for people with life-limiting conditions is in demand. Evidence shows that transfer of skills into practice is limited. Training can be improved by building on in-depth evidence and reflecting the complexity of actual interactions. Scientific advances from direct observational ‘conversation analytic’ studies of conversations in healthcare and beyond provide this evidence, but the linguistic complexities are often inaccessible to clinical trainers. We address this dilemma via a novel training initiative, ‘RealTalk’, designed to support trainers by increasing the authenticity and evidence base of end-of-life communication training for health and social care staff and trainees.METHODSWe conducted a development study to create a communication intervention for testing. In collaboration with stakeholders, we identified the rationale for the content and mode of delivery, converted research findings into an applied intervention, and tested and refined the intervention prior to launching the finished product. RESULTSUsing a conversation analytic approach, we made and analysed video recordings of real-life palliative care consultations in a large UK hospice. We transformed our findings into preliminary training resources comprising clips from the video recordings and accompanying written materials. We shared the materials with an advisory group of clinicians, educators and researchers. Based on feedback, we modified the materials. Trainers in UK higher education institutions, healthcare organisations and independent hospices piloted our materials within their own training and fed back. Further modifications followed in readiness for evaluation of acceptability, usability and effects on practice. The first version of RealTalk comprised two training modules, on ‘Broaching Dying’ and ‘Life Expectancy Enquiries’. Each module includes video clips from several patient cases, alongside written transcripts, case synopses and evidence-based learning points. CONCLUSIONSThe authentic and evidence-based RealTalk resources support experiential and reflective learning, focused on a range of communication problems and practices, for trainees from a wide range of backgrounds. Our process for developing RealTalk can serve as a prototype for developing other communication training resources based on data and findings from observational research on (recordings of) real-life interpersonal interactions.
WITHDRAWN: A Novel Endoscopic Nasopharyngectomy Technique Using Low-Temperature Plasma Radiofrequency Ablation with Piece Resection In Resectable Locally Recurrent Nasopharyngeal Carcinoma: Operative Video and Technical Nuances
Authors: Zou Xiong , Hua Yi-Jun , Liu You-Ping , Xie Yu-Long , Ouyang Yan-Feng , Liu Yong-Long , Wang Zhi-Qiang , You Rui , Ding Xi , Yang Qi , Yu Zi-Kun , Huang Pei-Yu , Chen Ming-Yuan 
Published: November 2021

Abstract
Objectives: Endoscopic nasopharyngectomy (ENPG) with en bloc resection has been well accepted in resectable locally recurrent nasopharyngeal carcinoma (rNPC), but it is difficult to master the technique and disseminate. We designed a novel method using low-temperature plasma radiofrequency ablation (LPRA) with piece resection and evaluated the survival benefit.Materials and Methods: A total of 56 resectable rNPC patients were retrospectively analyzed, and the following factors were assessed: ratio of R0 margin, overall survival rate (OS), local relapse-free survival rate (LRFS), and progression-free survival rate (PFS).Results: All surgeries were successfully performed without any severe postoperative complications or deaths. The median operation time was 130 minutes (range, 32–280 minutes), with little blood loss (median, 30 ml; range, 5–500 ml). The average number of hospital days postoperation was 3 days (range, 2–5 days). All cases (100.0%) had R0 margins. The nasopharyngeal defects were completely re-epithelialized in 53 (94.6%) patients. The 2-year OS, LRFS, and PFS rates of the entire cohort were 100%, 90.7% and 88.6%, respectively. Multivariate Cox proportional hazards model analysis indicated that cycles of radiotherapy were independent risk factors for LRFS (hazard ratio [HR], 16.607; 95% CI 1.638–168.417; P = 0.017) and PFS (HR, 7.424; 95% CI 1.190–46.320; P = 0.032).Conclusions: Radical endoscopic nasopharyngectomy is a novel, safe and relatively easier method for treating resectable rNPC by using low-temperature plasma radiofrequency ablation with piece resection. However, further data and longer follow-up time are needed to prove its efficacy.
Revealing RCOR2 as a regulatory component of nuclear speckles
Authors: Rivera Carlos , Verbel Daniel , Arancibia Duxan , Lappala Anna , González Marcela , Guzmán Fabián , Merello Gianluca , Lee Jeannie T. , Andrés María Estela 
Published: November 2021

Abstract
Background
Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here we characterize the nature of nuclear granules formed by REST corepressor 2 (RCOR2), a nuclear protein essential for pluripotency maintenance and central nervous system development.
Results
Using biochemical approaches and high-resolution microscopy, we reveal that RCOR2 is localized in nuclear speckles across multiple cell types, including neurons in the brain. RCOR2 forms complexes with nuclear speckle components such as SON, SRSF7, and SRRM2. When cells are exposed to chemical stress, RCOR2 behaves as a core component of the nuclear speckle and is stabilized by RNA. In turn, nuclear speckle morphology appears to depend on RCOR2. Specifically, RCOR2 knockdown results larger nuclear speckles, whereas overexpressing RCOR2 leads to smaller and rounder nuclear speckles.
Conclusion
Our study suggests that RCOR2 is a regulatory component of the nuclear speckle bodies, setting this co-repressor protein as a factor that controls nuclear speckles behavior.
Automatic Detection of Arrhythmias From An ECG Signal Using An Auto-Encoder And SVM Classifier
Authors: Ojha Manoj Kumar , Wadhwani Sulochna , Wadhwani Arun Kumar , Shukla Anupam 
Published: November 2021

Abstract
Millions of people worldwide are affected by arrhythmias. Arrhythmias are abnormal activity of the heart functioning. Some arrhythmias are harmful to the heart and can cause sudden mortality. The electrocardiogram (ECG) is a significant tool in cardiology for the diagnosis of arrhythmia beats. Computer-aided diagnosis (CAD) systems have been proposed in several studies to automatically classify different types of arrhythmias from ECG signals. To improve the classification of arrhythmias, a new end-to-end feature learning and classification model has been developed. This work focuses on the implementation of a one-dimensional convolution neural network (1D-CNN) model based on an auto-encoder convolution network (ACN) that learned the best ECG features from each heartbeat window. After that, we applied a Support Vector Machine (SVM) classifier for auto-encode features in order to detect the four different types of arrhythmic beats, including normal beats. These arrhythmia beats are left bundle branch block (L), right bundle branch block (R), paced beats (P), and premature ventricular contractions (V). using the MIT-BIH arrhythmia database. The statistical performance of the model is evaluated using tenfold cross-validation strategies and obtained as an overall accuracy of 98.84%, average accuracy of 99.53%, sensitivity of 98.24% and precision of 97.58%, respectively. This model has presents better results than other state-of-the-art models. Therefore, this approach may also help in clinical heart care systems.