bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the early impact of a hospital-based health technology assessment program, smart innovation
Authors: Landaas Erik J. , Hansen Ryan N. , Baird Geoffrey S. , Sullivan Sean D. 
Published: July 2021

Abstract

Objective
We evaluated the early impact of a new hospital-based health technology assessment (HB-HTA) program, called Smart Innovation, at the University of Washington Medical Center (UWMC).

Methods
We compared the UWMC's utilization trends for two surgical procedures to control hospitals by evaluating the difference before and after adoption decisions: (i) a new filter for transcatheter aortic valve replacement (TAVR) procedures that treat aortic valve stenosis and (ii) microwave ablation (MWA) for treating hepatocellular carcinoma. We used descriptive statistics to assess the difference between the UWMC and controls for TAVR and MWA procedures and multivariate difference-in-differences (DID) analyses to test for statistical significance.

Results
The UWMC experienced a 10 percent reduction in TAVR procedures compared with controls following the implementation of the TAVR Sentinel filter. The DID regression model indicated a 1.5 reduction in the number of TAVR procedures per quarter at the UWMC between the pre- and post period, which was not statistically significant (p-value: .87). The UWMC experienced a 51 percent reduction in utilization when compared with controls for MWA procedures in the pre- and post periods. The DID model for MWA indicated an 18.8 decrease in utilization per quarter during the study period for the UWMC, which was statistically significant (p-value: .0007). For MWA procedures, the UWMC experienced a $647,658 dollar reduction in total costs in the post period compared with controls.

Conclusions
When the UWMC used HB-HTA methods for technology adoption, there was a reduction in utilization and total costs when compared with controls; however, when the UWMC adopted a new technology without using HB-HTA methods, there was no difference in utilization.
How to integrate evidence from patient preference studies into health technology assessment: a critical review and recommendations
Authors: Marsh Kevin , de Bekker-Grob Esther , Cook Nigel , Collacott Hannah , Danyliv Andriy 
Published: July 2021

Abstract
Health technology assessment (HTA) agencies vary in their use of quantitative patient preference data (PP) and the extent to which they have formalized this use in their guidelines. Based on the authors' knowledge of the literature, we identified six different PP “use cases” that integrate PP into HTA in five different ways: through endpoint selection, clinical benefit rating, predicting uptake, input into economic evaluation, and a means to weight all HTA criteria. Five types of insight are distinguished across the use cases: understanding what matters to patients, predicting patient choices, estimating the utility generated by treatment benefits, estimating the willingness to pay for treatment benefits, and informing distributional considerations. Summarizing the literature on these use cases, we recommend circumstances in which PP can add value to HTA and the further research and guidance that is required to support the integration of PP in HTA. Where HTA places more emphasis on clinical outcomes, novel endpoints are available; or where there are already many treatment options, PP can add value by helping decision makers to understand what matters to patients. Where uptake is uncertain, PP can be used to estimate uptake probability. Where indication-specific utility functions are required or where existing utility measures fail to capture the value of treatments, PP can be used to generate or supplement existing utility estimates. Where patients are paying out of pocket, PP can be used to estimate willingness to pay.
Visual imagination and cognitive mapping of a virtual building
Authors: Jeffery Kate , Guo Wanying , Ball Danny , Rodriguez-Sanchez Julia 
Published: July 2021

AbstractWe investigated the contribution of visual imagination to the cognitive mapping of a building when initial exploration was simulated either visually by using a passive video walk-through, or mentally by using verbal guidance. Building layout had repeating elements with either rotational or mirror symmetry. Cognitive mapping of the virtual building, determined using questionnaires and map drawings, was present following verbal guidance but inferior to that following video guidance. Mapping was not affected by the building's structural symmetry. However, notably, it correlated with small-scale mental rotation scores for both video and verbal guidance conditions. There was no difference between males and females. A common factor that may have influenced cognitive mapping was the availability of visual information about the relationships of the building elements, either directly perceived (during the video walk-through) or imagined (during the verbal walk-through and/or during recall). Differences in visual imagination, particularly mental rotation, may thus account for some of the individual variance in cognitive mapping of complex built environments, which is relevant to how designers provide navigation-relevant information.
A novel partial ambiguity method for multi-GNSS real-time kinematic positioning
Authors: Li Haiyang , Nie Guigen , Wang Jing , Wu Shuguang , He Yuefan 
Published: July 2021

AbstractRecent progress in using real-time kinematic (RTK) positioning has motivated the exploration of its application due to its high accuracy and efficiency. However, poorly-observed satellite data will cause unfixed ambiguities and markedly biased solutions. A novel partial ambiguity resolution method, named the irrespective of integer ambiguity resolution (IIAR) model, is proposed and applied to improve the reliability of ambiguity resolution. The proposed method contains initial ambiguity resolution and irrespective of integer ambiguity processes. The initial ambiguity resolution process applies an iterative partial ambiguity resolution method to obtain an approximate solution. The irrespective of integer ambiguity process transforms the approximate solution to a high-precision solution. Experiments show that the approximate solution is unreliable when the initial ambiguity resolution process has small redundancy, and the proposed method can obtain better results for those cases. The IIAR method showed about a 40% improvement of multi-GNSS ambiguity success rate and about a 25% improvement of standard deviation. Therefore, these results show that the proposed IIAR method can improve the results of multi-GNSS RTK positioning significantly.
Evidence Lacking for Cannabis Users Slacking: A Longitudinal Analysis of Escalating Cannabis Use and Motivation among Adolescents
Authors: Pacheco-Colón Ileana , Hawes Samuel W. , Duperrouzel Jacqueline C. , Gonzalez Raul 
Published: July 2021

AbstractObjective:Reduced motivation is often noted as a consequence of cannabis use. However, previous work has yielded mixed results and focused largely on adults. To address these limitations, this study examined longitudinal associations between cannabis use and self-reported motivation in a large adolescent sample.Method:Participants were 401 adolescents aged 14–17 at baseline who completed five bi-annual assessments. We assessed motivation at three timepoints using two self-report questionnaires: the Apathy Evaluation Scale and the Motivation and Engagement Scale (disengagement, persistence, planning, self-efficacy, and valuing school subscales). Controlling for relevant covariates, we used latent growth curve modeling to characterize patterns of cannabis use and motivation over time, examining bidirectional influences between these processes.Results:On average, adolescent cannabis use frequency increased significantly over time. The disengagement and planning facets of motivation also increased significantly over time, whereas other aspects of motivation remained stable. At baseline, greater cannabis use was associated with greater disengagement, lower planning, and lower valuing of school. Greater baseline cannabis use also predicted lesser increases in disengagement over time. After controlling for the effect of sex, age, depression, and use of alcohol and nicotine, only the baseline association between cannabis use and valuing school remained significant.Conclusions:Our results do not support a prospective link between cannabis use and reduced motivation among adolescents. Although most observed associations were accounted for by covariates, greater cannabis use was cross-sectionally associated with lower perceived value of school, which may contribute to poorer educational and later life outcomes.
Down to Earth With Nuclear Electromagnetic Pulse: Realistic Surface Impedance Affects Mapping of the E3 Geoelectric Hazard
Authors: Love Jeffrey J. , Lucas Greg M. , Murphy Benjamin S. , Bedrosian Paul A. , Rigler E. Joshua , Kelbert Anna 
Published: July 2021

AbstractAn analysis is made of Earth‐surface geoelectric fields and voltages on electricity transmission power‐grids induced by a late‐phase E3 nuclear electromagnetic pulse (EMP). A hypothetical scenario is considered of an explosion of several hundred kilotons set several hundred kilometers above the eastern‐midcontinental United States. Ground‐level E3 geoelectric fields are estimated by convolving a standard parameterization of E3 geomagnetic field variation with magnetotelluric Earth‐surface impedance tensors derived from wideband measurements acquired across the study region during a recent survey. These impedance tensors are a function of subsurface three‐dimensional electrical conductivity structure. Results, presented as a movie‐map, demonstrate that localized differences in surface impedance strongly distort the amplitude, polarization, and variational phase of induced E3 geoelectric fields. Locations with a high degree of E3 geoelectric polarization tend to have high geoelectric amplitude. Uniform half‐space models and one‐dimensional, depth‐dependent models of Earth‐surface impedance, such as those widely used in government and industry reports informing power‐grid vulnerability assessment projects, do not provide accurate estimates of the E3 geoelectric hazard in complex geological settings. In particular, for the Eastern‐Midcontinent, half‐space models can lead to (order‐one) overestimates/underestimates of EMP‐induced geovoltages on parts of the power grid by as much as1,000 volts (a range of 2,000 volts)—comparable to the amplitudes of the geovoltages themselves.
Untangling the Relationship Between AMOC Variability and North Atlantic Upper‐Ocean Temperature and Salinity
Authors: Chiang J. C. H. , Cheng W. , Kim W. M. , Kim S. 
Published: July 2021

AbstractThe relationship between Atlantic meridional overturning circulation (AMOC) variability and high‐latitude North Atlantic buoyancy changes is complicated by the latter both driving, and responding to, AMOC changes. A maximum covariance analysis applied to a 1,201‐year preindustrial control simulation reveals two leading modes that separate these two distinct roles of North Atlantic temperature and salinity as related to AMOC variability. A linear combination of the two modes accounts for most of the variation of a widely used AMOC index. The same analysis applied to another control simulation known to possess two distinct regimes of AMOC variability—oscillatory and red‐noise—suggests that the North Atlantic buoyancy‐forced AMOC variability is present in both regimes but is weaker in the latter, and moreover there is pronounced multidecadal/centennial AMOC behavior in the latter regime that is unrelated to North Atlantic buoyancy forcing.
Sound Velocity of MgSiO3 Majorite Garnet up to 18 GPa and 2000 K
Authors: Zhou Chunyin , Gréaux Steeve , Liu Zhaodong , Higo Yuji , Arimoto Takeshi , Irifune Tetsuo 
Published: July 2021

AbstractMgSiO3 majorite is the most significant endmember of the Al‐deficient majorite garnets that form at depths higher than ∼400 km, in the mantle transition zone (MTZ). Here, we report elastic wave velocity measurements on polycrystalline MgSiO3 majorite samples, up to 18.4 GPa and 2000 K by ultrasonic interferometry techniques combined with in situ X‐ray diffraction measurements in a multianvil apparatus. Our data show MgSiO3 majorite has the lowest elastic moduli among silicate garnet endmembers, under the pressure and temperature conditions of the MTZ. These new data combined with those of other garnet endmembers allowed to estimate VP and VS of majorite with compositions relevant to the MTZ. The results suggest that variation of MgSiO3 component in garnet may play a role for interpreting seismic gradients atop the 410‐km discontinuity while below ∼520 km, the velocity contrasts hold too low values to explain the discrepancy between mineral physics data and seismological observations.
A Solid Interpretation of Bright Radar Reflectors Under the Mars South Polar Ice
Authors: Smith I. B. , Lalich D. E. , Rezza C. , Horgan B. H. N. , Whitten J. L. , Nerozzi S. , Holt J. W. 
Published: July 2021

AbstractBright radar reflections observed beneath the south polar layered deposits (SPLD) by the Mars Advanced Radar for Subsurface and Ionosphere Sounding instrument were interpreted to represent liquid water, but the required amounts of salt and heat to form and maintain liquids in this location are implausible given what is known about Mars. Here, we present another hypothesis that accounts for the bright reflections: hydrated and cold clay‐rich deposits at the base of the SPLD create the observed radar response. To support this hypothesis, we present experimental measurements and wave propagation modeling that show that smectites, cooled to 230 K, have real and imaginary parts of the dielectric permittivity large enough to cause the bright reflections, even when mixed with other materials. Further, we find that absorptions attributable to these minerals are present in south polar orbital visible‐near infrared reflectance spectra. Because these minerals are present at the south pole and can cause the reflections, we believe this to be a more viable scenario than the liquid water interpretation.
Increase in CO2 Uptake Capacity in the Arctic Chukchi Sea During Summer Revealed by Satellite‐Based Estimation
Authors: Tu Zebin , Le Chengfeng , Bai Yan , Jiang Zongpei , Wu Yingxu , Ouyang Zhangxian , Cai Wei‐Jun , Qi Di 
Published: July 2021

AbstractThe capacity of CO2 uptake in the Chukchi Sea is particularly sensitive to rapid physical and biological changes. However, scarce field observations pose a challenge in understanding the long‐term trend of CO2 uptake capacity on this continental shelf. We adopted a machine‐learning‐based approach to construct a 17‐years (2003–2019) long‐term time series of summer sea surface partial pressure of CO2 (pCO2) from remote sensing products. We show that the long‐term increase in CO2 uptake capacity can be attributed to strong and enhanced biological uptake. In addition, the intraseasonal variability of surface pCO2 in early summer confirms the crucial role of sea ice melt and the subsequently enhanced photosynthesis as soon as the surface ocean converts into an open system. Our results thus highlight the use of remote sensing data in interpolating/extrapolating the highly dynamic carbonate system in the continental shelf sea and shed light into future studies involving machine learning or algorithms.
Climatic Forcing of Plio‐Pleistocene Formation of the Modern Limpopo River, South Africa
Authors: Yang Jing , Nie Junsheng , Garzanti Eduardo , Limonta Mara , Andò Sergio , Vermeesch Pieter , Zhang Haobo , Hu Xiaofei , Wang Zhao , Zhao Baojin , Ncube Lindani , Stevens Thomas , Li Maotong , Li Hua , Chen Taian , Miao Yunfa , Pan Baotian 
Published: July 2021

AbstractUnderstanding the evolution of river systems in southern Africa is fundamental to constrain the evolution of landscape and sediment dispersal patterns. It is widely considered that the upper Zambezi River was connected with the Limpopo River during the Cretaceous, forming what was then the largest river in Africa. Crustal flexure during the Paleogene severed the upper Zambezi drainage from the Limpopo, setting the framework of the modern Zambezi and Limpopo River systems. We present first evidence—based on heavy‐mineral assemblages from cores drilled offshore of the Limpopo River mouth and samples collected in different reaches of the modern Limpopo River, integrated with magnetic susceptibility, detrital‐zircon geochronology, and geomorphological analysis—suggesting that the current Limpopo River formed recently in the Plio‐Quaternary. Plio‐Quaternary climate change is envisaged to have controlled the recent dynamics of river drainage and consequent distribution of sediment loads, as observed in many other transcontinental rivers worldwide.
Lack of intrafollicular memory CD4 + T cells is predictive of early clinical failure in newly diagnosed follicular lymphoma
Authors: Mondello Patrizia , Fama Angelo , Larson Melissa C. , Feldman Andrew L. , Villasboas Jose C. , Yang Zhi-Zhang , Galkin Ilia , Svelolkin Viktor , Postovalova Ekaterina , Bagaev Alexander , Ovcharov Pavel , Varlamova Arina , Huet Sarah , Tesson Bruno , McGrath Kaitlyn R. , Slager Susan , Link Brian K. , Syrbu Sergei , Novak Anne J. , Habermann Thomas M. , Witzig Thomas E. , Nowakowski Grzegorz S. , Salles Gilles , Cerhan James R. , Ansell Stephen M. 
Published: July 2021

AbstractDespite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poor outcome. Cells in the microenvironment may be a key contributor to treatment failure. We used a discovery and validation study design to identify microenvironmental determinants of early failure and then integrated these results into the FLIPI. In total, 496 newly diagnosed FL grade 1–3 A patients who were prospectively enrolled into the MER cohort from 2002 to 2012 were evaluated. Tissue microarrays were stained for CD4, CD8, FOXP3, CD32b, CD14, CD68, CD70, SIRP-α, TIM3, PD-1, and PD-L1. Early failure was defined as failing to achieve event-free survival at 24 months (EFS24) in immunochemotherapy-treated patients and EFS12 in all others. CyTOF and CODEX analysis were performed to characterize intratumoral immunophenotypes. Lack of intrafollicular CD4 expression was the only predictor of early failure that replicated with a pooled OR 2.37 (95%CI 1.48–3.79). We next developed a bio-clinical risk model (BioFLIPI), where lack of CD4 intrafollicular expression moved patients up one FLIPI risk group, adding a new fourth high-risk group. Compared with BioFLIPI score of 1, patients with a score of 2 (OR 2.17; 95% CI 1.08–4.69), 3 (OR 3.53; 95% CI 1.78–7.54), and 4 (OR 8.92; 95% CI 4.00–21.1) had increasing risk of early failure. The favorable intrafollicular CD4 T cells were identified as activated central memory T cells, whose prognostic value was independent from genetic features. In conclusion, lack of intrafollicular CD4 expression predicts early failure in FL and combined with FLIPI improves identification of high-risk patients; however, independent validation is warranted.
Drug importation: limitations of current proposals and opportunities for improvement
Authors: Scheckel Caleb J. , Vincent Rajkumar S. 
Published: July 2021

AbstractDrug importation is a policy proposal to help alleviate rising pharmaceutical prices. Restrictions on drug importation stem from the Federal Food, Drug, and Cosmetic Act but authorization of importation can be made by the Health and Human Services (HHS) Secretary. During the Trump administration a number of states passed laws to develop a drug importation programs, however, none have been authorized by HHS. Limitations of these importation programs include sole reliance on Canada, exclusion of high-cost drugs like biologics, and persistent legal hazard of the Personal Importation Program. Potential revisions to current law include expansion of countries approved for importation, inclusion of biologics, and codifying protection for personal importation. Drug importation policies are not a panacea to address rising pharmaceutical prices but may blunt prices while more permanent solutions are pursued.
MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells
Authors: Fu Shu-Hua , Lai Mei-Chen , Zheng Yun-Yao , Sun Ya-Wen , Qiu Jing-Jing , Gui Fu , Zhang Qian , Liu Fei 
Published: July 2021

AbstractThe dysregulated microRNAs (miRNAs) are involved in diabetic retinopathy progression. Epithelial mesenchymal transition (EMT) and cell permeability are important events in diabetic retinopathy. However, the function and mechanism of miR-195 in EMT and cell permeability in diabetic retinopathy remain largely unclear. Diabetic retinopathy models were established using streptozotocin (STZ)-induced diabetic mice and high glucose (HG)-stimulated ARPE-19 cells. Retina injury was investigated by hematoxylin–eosin (HE) staining. EMT and cell permeability were analyzed by western blotting, immunofluorescence, wound healing, and FITC-dextran assays. MiR-195 expression was detected via qRT-PCR. YY1, VEGFA, Snail1, and Smurf2 levels were detected via western blotting. The interaction relationship was analyzed via ChIP, Co-IP, or dual-luciferase reporter assay. The retina injury, EMT, and cell permeability were induced in STZ-induced diabetic mice. HG induced EMT and cell permeability in ARPE-19 cells. MiR-195, YY1, VEGFA, and Snail1 levels were enhanced, but Smurf2 abundance was reduced in STZ-induced diabetic mice and HG-stimulated ARPE-19 cells. VEGFA knockdown decreased Snail1 expression and attenuated HG-induced EMT and cell permeability. YY1 silence reduced VEGFA and Snail1 expression, and mitigated HG-induced EMT and cell permeability. YY1 could bind with VEGFA and Snail1, and it was degraded via Smurf2-mediated ubiquitination. MiR-195 knockdown upregulated Smurf2 to decrease YY1 expression and inhibited HG-induced EMT and cell permeability. MiR-195 targeted Smurf2, increased expression of YY1, VEGFA, and Snail1, and promoted HG-induced EMT and cell permeability. MiR-195 promotes EMT and cell permeability of HG-stimulated ARPE-19 cells by increasing VEGFA/Snail1 via inhibiting the Smurf2-mediated ubiquitination of YY1.