bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Coffee and Caffeine Consumption and Renal Function: Insight from Individual-Level Data, Mendelian Randomization, and Meta-Analysis
Authors: Mazidi Mohsen , Dehghan Abbas , Mikhailidis Dimitri , Jóźwiak Jacek , Covic Adrian , Sattar Naveed , Banach Maciej , Lipid and Blood Pressure Meta-analysis Collab on behalf of the , (ILEP) and the International Lipid Expert Panel 
Published: December 2021

IntroductionBy applying on two-sample Mendelian randomization and systematic review and meta-analysis we investigated the association between caffeine and coffee intake with prevalent CKD and markers of renal function.Material and methodsFor the individual data analysis we analysed the NHANES data on renal function markers and caffeine intake. MR was implemented by using summary-level data from the largest ever GWAS conducted on coffee intake (N=91,462) and kidney function.ResultsFinally, we included the data of 18,436 participants, 6.9% had prevalent CKD (based on eGFR). Caffeine intake for general population was 131.1±1.1 mg. The percentage of participants with CKD, by caffeine quartile was 16.6% in the first (lowest) quartile, 13.9% in the second, 12.2% in the third and 11.0% in the top quartile (p<0.001). After adjustment, for increasing quartiles for caffeine consumption, mean urine albumin, albumin-creatinine ratio and estimated glomerular filtration rate (GFR) did not change significantly (p>0.234). In fully adjusted logistic regression models, there was no significant difference in chances of CKD prevalence (p-trend=0.745). In the same line, results of MR showed no impact of coffee intake on CKD (IVW=β: -0.0191, SE: 0.069, p=0.781), on eGFR (overall= IVW= β: -0.0005, SE: 0.005, p=0.926) both in diabetic (IVW= β: -0.006, SE: 0.009, p=0.478), and non-diabetic patients (IVW= β: -6.772, SE: 0.006, p=0.991). Results from the meta-analysis indicted that coffee consumption was not significantly associated with CKD (OR: 0.85, 95%CI 0.71-1.02, p=0.090, n=6 studies, I2=0.32).ConclusionsBy implementing on different strategies, we have highlighted no significant association between coffee consumption with renal function and chance of CKD.
A gramática nas escolas hoje: como agem e como pensam os professores
Authors: Lima Maria Claudete , Sousa Camila Stephane Cardoso , Moura Ana Célia Clementino 
Published: December 2021

Há mais de vinte anos, os documentos oficiais recomendam um ensino de gramática contextualizada (BRASIL, 1998; BRASIL, 2000; BRASIL, 2018). Data do mesmo período a infinidade de trabalhos que discutem a questão do ensino de língua portuguesa e de gramática (POSSENTI, 1996; TRAVAGLIA, 1996; NEVES, 1990; 2003; VIEIRA, S.R.; BRANDÃO, S.F., 2007). Recentemente, a Base Nacional Comum Curricular acrescentou ao nome “análise linguística” － como passou a ser chamado o ensino de gramática nos Parâmetros Curriculares Nacionais, para destacar a necessidade de se partir do texto － o nome “semiótica”, para abranger a análise de textos multimodais. Nosso objetivo neste trabalho é mostrar que, apesar do avanço nas pesquisas e das recomendações nos documentos oficiais a prática do ensino de gramática nas escolas ainda não alcança a desejada integração texto e gramática. Para tanto, analisamos quali-quantitativamente, com base em Neves (2002), as respostas a um questionário com perguntas abertas e fechadas aplicado a 171 sujeitos, 88 professores de língua portuguesa ainda em formação e 83 professores em atividade. Os resultados mostram que, embora reconheçam teoricamente a validade de uma gramática atrelada aos textos, os professores em formação e em atividade têm dificuldade em aplicar os conhecimentos de linguística e as recomendações oficiais na prática do ensino de gramática. Tal resultado indicia que os cursos de formação de professores de língua precisam enfrentar esta questão, seja reformulando a grade para incluir disciplinas que deem conta de um ensino produtivo para além das disciplinas teóricas, seja inserindo, nas disciplinas já existentes unidades de aplicação dos conteúdos teóricos.
Atualização e Relações interativas: situações favorecedoras do desenvolvimento profissional do tecnólogo-professor iniciante
Authors: Sousa Laura Maria Andrade , Moura Maria da Glória Carvalho 
Published: December 2021

O presente artigo é fruto de recorte de uma investigação sobre a formação e o desenvolvimento profissional dos tecnólogos-professores em início de carreira na Educação Profissional, desenvolvida durante o mestrado no Programa de Pós-Graduação em Educação da Universidade Federal do Piauí. Em termos metodológicos, configura-se como uma pesquisa de abordagem qualitativa, que tem como objetivo geral analisar as situações que contribuem para o desenvolvimento profissional do tecnólogo-professor em início de carreira. De modo específico, buscou-se: Identificar as situações consideradas relevantes pelo tecnólogo-professor para seu desenvolvimento profissional docente e compreender o processo de construção do desenvolvimento profissional do tecnólogo-professor. Para sua realização, colaboraram seis tecnólogos-professores que atuam em campi de um Instituto Federal de Educação. Os dados foram organizados em torno de duas categorias analíticas e interpretados com base na Análise de Discurso (AD) francesa e em pesquisadores dessa temática. Os resultados apontam que a relação com os pares mais experientes e com os alunos são os principais elementos que contribuem para a consolidação da aprendizagem da docência e do desenvolvimento profissional dos tecnólogos-professores iniciantes. Concluímos que há necessidade de acompanhamento e apoio da coordenação pedagógica e estreitamento das relações institucionais entre departamentos e coordenações.
Pensamento e ação em Pinto Ferreira: o Direito Constitucional na Faculdade de Direito do Recife
Authors: Continentino Marcelo Casseb , Silva Renan Apolônio de Sá 
Published: December 2021

Este artigo tem por objetivo investigar a trajetória constitucional do professor Luiz Pinto Ferreira durante o período vivenciado na Faculdade de Direito do Recife (FDR), tanto como aluno, quanto como professor. Também busca analisar o impacto de seu pensamento na história constitucional brasileira. Inspirado no método indiciário de Carlo Ginzburg, que valoriza as particularidades e os pequenos detalhes do dia a dia como estratégia para compreender o contexto histórico geral, a pesquisa revisitou o percurso acadêmico, jurídico (como filósofo, professor e pensador social) e político do professor Luiz Pinto desde os anos 30. Verificou-se que, dada a extensão e profundidade de suas principais obras no campo do Direito Constitucional e Público, o professor contribuiu para o desenvolvimento do pensamento constitucional brasileiro na qualidade de jurista, professor e político, tendo especial participação no processo de elaboração da Constituição Federal de 1988, como membro integrante da Comissão Afonso Arinos, e da Constituição do Estado de Pernambuco de 1989, como autor do seu anteprojeto. Conclui-se que a associação de seu pensamento constitucional e de sua ação política, de modo indissociável à sua condição de professor e catedrático da Faculdade de Direito do Recife, também contribuiu para a projetar a imagem da Faculdade de Direito e da Universidade Federal de Pernambuco (UFPE) como um relevante centro jurídico e político do país.
The extent of upskilling of the argentine labor market: a simple analysis
Authors: Esposto Alexis S. , Giménez Luis Federico 
Published: December 2021

Over the last three decades the labor market of most developed countries have experienced a sustained period of upskilling. This means an overall increase in the skill requirement of jobs determined by the demand for skilled labor. This suggests that their labor demand has become more skill intensive, shifting towards skilled workers relatively to unskilled workers. An analysis of job growth of the Argentine labor market between 1997 and 2009 using data from the EPH, evidences a process of deskilling over this period, with serious implications in terms of competitiveness and about issues related to increasing social and economic inequality.
Desarrollo y democracia el estado de la relacion post- reformas
Authors: Raus Diego Martín 
Published: December 2021

Este trabajo analiza los cambios conceptuales, institucionales y políticos que afectaron a la relación entre desarrollo y democracia en América Latina luego, y como resultado, de las reformas económicas de los '90 (Consenso de Washington). La sociología, la politología y la economía del desarrollo (CEPAL) tuvieron su auge en la década de los `50 al igualar, conceptualmente y como programa político, la relación entre desarrollo económico- modernización social- gobernabilidad política y estabilidad democrática. Este paradigma se vio interesadamente deconstruido en los `90 a partir de los efectos sociopolíticos que atravesaron negativamente a las sociedades latinoamericanas con la reincorporación de la economía de mercado (neoliberalismo). Analizar esa operación discursiva y política es el objetivo de este trabajo.
When more schooling is not worth the effort: another look at the dropout decisions of disadvantaged students
Authors: Patron Rossana 
Published: December 2021

This paper shows that when student heterogeneity is introduced in the analysis, differences in the quality of education and in the probability of repetition, typical in developing countries, mark the contrast between an attractive and an inconvenient investment in education. The methodology associates educational quality
and repetition rates with educational returns. In particular, it makes apparent that lower secondary education, in the case of Uruguay, is an inconvenient investment for disadvantaged students, even disregarding the possibility of such students not being able to afford the opportunity costs, this fact probably also explains the
heavy dropout rates of this student type in many developing countries.
Let it float: new empirical evidence on de facto exchange rate regimes and growth in Latin America
Authors: Bermúdez Cecilia , Dabús Carlos 
Published: December 2021

This paper reassesses the evidence presented in Levy-Yeyati and Sturzenegger (LYS) (2003) on the relation between exchange rate regimes and economic growth. We use their de facto classification as well as their database, in order to gain robustness and efficiency in the results. We run System GMM estimations.

Additionally, we focus on Latin American countries for the period 1974-2004. Differently to LYS, our evidence indicates that exchange rate regimes are not significant to explain economic growth, both in a worldwide sample of countries and particularly in Latin America. However, in this region flexible regimes appear to have more advantages in terms of the role of the determinants of economic growth in relation to the other exchange regimes.
UPAYA PENCEGAHAN INFEKSI SALURAN KEMIH OLEH PERAWAT PADA PASIEN TERPASANGNYA KATETER DI RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN
Authors: Putra Ritonga Edisyah 
Published: December 2021

Infeksi saluaran kemih merupakan penyakit yang paling banyak ditemukan di tempat pelanyanan kesehatan. Sebagian besar infeksi saluran kemih disebabkan oleh bakteri tetapi virus dan jamur juga dapat menjadi penyebabnya. Infeksi bakteri sering diakibatkan Escherichia coli. Tujuan penelitian ini adalah mengetahui upanya pencengahan infeksi saluran kemih oleh perawat pada pasien terpasangnya kateter di RSU Imelda Pekerja Indonesia Medan. Jenis penelitan ini adalah penelitian kuantitatif dengan desain deskritif observasioanal dan jumlah sampel dalam penelitian ini adalah 39 orang. Berdasarakan penelitian yang telah dilakukan bahwa mayoritas jenis kelamin responden adalah perempuan yaitu sebanyak 26 responden (66,7%) dan minoritas jenis kelamin responden adalah laki-laki yaitu sebayak 13 responden (33,3%). Mayoritas umur responden adalah berumur 20-24 tahun yaitu sebanyak 18 responden (46,2%) dan minoritas umur responden adalah berumur >36 tahun yaitu sebayak 4 responden (10,2%), mayoritas lama bekerja responden adalah 0-4 tahun yaitu sebanyak 29 responden (74,4%) dan minoritas lama bekerja responden adalah >10 tahun yaitu sebayak 4 responden (10,3%). Mayoritas pendidikan responden adalah D-III yaitu sebanyak 33 responden (84,7%) dan minoritas pendidikan responden adalah S-I Keperawatan yaitu sebayak 6 responden (15,3%). Berdasarkan dari hasil penelitian yang telah dilakukan dengan memberikan quisioner kepada perawat ditemukan bahwa mayoritas upaya pencegahan infeksi saluran kemih yang dilakukan oleh perawat pada pasien terpasang kateter adalah baik yaitu sebanyak 29 responden (74,3%) dan minoritas upaya pencegahan infeksi saluran kemih yang dilakukan adalah kurang baik yaitu sebanyak 10 responden (25,7%). Bagi pihak Rumah Sakit Umum Imelda Pekerja Indonesia Medan diharapkan agar lebih meningkatkan kepatuhan dalam melakukan perawatan kateter urine dalam pencegahan infeksi saluran kemih.
PENGARUH LATIHAN FISIK DENGAN FLEXIBILITY EXERCISES TERHADAP KEMAMPUAN ACTIVITY DAILY LIVING’S (ADL’s) PASIEN KANKER DI MURNI TEGUH MEMORIAL HOSPITAL
Authors: Tarihoran Yusrial , Banjarnahor Seriga 
Published: December 2021

Kanker merupakan penyakit dengan pertumbuhan dan penyebaran sel abnormal oleh berbagai faktor seperti penggunaan tembakau, genetik, hormon, dan gangguan kekebalan tubuh sehingga sering mengalami keluhan fisik seperti kelemahan akibat kurangnya energi didalam tubuh dan berdampak terhadap kemampuan melakukan Activity Daily Living’s (ADL’s). Penelitian ini bertujuan untuk menganalisis pengaruh latihan fisik dengan flexibility exercises terhadap kemampuan Activity Daily living’s (ADL’s)pasien kanker di Murni Teguh Memorial Hospital dengan kriteria sampel yaitu pasien yang menjalani kemoterapi, tidak memiliki luka akibat kanker, tidak mengalami anemia, tidak mengalami fraktur, berjenis kelamin perempuan kooperatif dan memiliki rekomendasi dari dokter untuk melakukan latihan fisik dengan flexibility exercises. Metode penelitian ini menggunakan rancangan one group pre-post test designe. Latihan fisik dengan flexibility exercises dilakukan minimal 30 menit setiap kali melakukan latihan dan dilakukan 3 kali seminggu selama 30 kali pertemuan dengan jumlah sampel sebanyak 30 orang dengan teknik accidental sampling. Luaran wajib penelitian ini berupa publikasi ilmiah jurnal nasional tidak terakreditasi dan luaran tambahan berupa keynot speaker/invited dalam temu ilmiah lokal dan nasional serta pembuatan bahan ajar di bidang pelayanan asuhan keperawatan pasien kanker dan juga paliatif care di bidang onkologi (kanker). Adapun tujuan dari Tingkat Kesiapterapan Teknologi (TKT) penelitian ini adalah berbagai produk alat kesehatan, berupa perumusan topik-topik penelitian, menyusun hipotesis, merencanakan rancangan experimen untuk menemukan solusi permasalahan, mengidentifikasi potensi dan peluang target terapi, pembuktian terhadap kebenaran konsep (proof-of-concept), penyusunan prosedur dan metode yang digunakan dalam studi klinis dan publikasi pembuktian kebenaran konsep.
A Shared Space: Metatheatricality in Wilder's Unfinished Play The Emporium
Authors: Hamlett Bonnie Georgette 
Published: December 2021

Abstract
As an incomplete play, the scenes from The Emporium demonstrate Wilder's continued experimentation with character and metatheatricality. Through two distinctly different characters, Wilder explores the significance of the Everyman archetype and the purpose it serves in theater. John, the protagonist, represents Wilder's more traditional and familiar tendency to favor the Everyman in Everyone but still challenges the limitations of its archetype. In contrast, the Member of the Audience is by title inherently an Everyman and another of Wilder's uniquely metatheatrical figures existing in the space outside of his play-within-a-play structure. The Emporium offers new insights into how Wilder understood the Everyman as a character within metatheatricality and what it means to be the ideal audience for his theater.
THE USE OF THE HERBAL PREPARATION EVIKA IN THE TREATMENT OF PREMENSTRUAL SYNDROME
Authors: НУРГАЛИЕВА Л. И. , КУАТБЕКОВА Д.М. 
Published: December 2021

Предменструальный синдром (ПМС) - патологический симптомокомплекс, который значительно снижает качество жизни женщины. Несмотря на то, что этиология и патогенез до настоящего времени изучены недостаточно, определены направления в диагностике, лечении и профилактике, которым необходимо следовать. Лечение ПМС должно быть дифференцированным, учитывающим состояние общего и репродуктивного здоровья женщины, сопутствующие заболевания, степень тяжести ПМС, переносимость терапии и т. д.В настоящее время все более широкое применение в лечении ПМС находят фитопрепараты (ФП). Целью исследования явилось изучение эффективности фитопрепарата «Эвика» в лечении ПМС легкой и средней формы. Полученные результаты свидетельствуют об эффективности данного препарата в устранении вегетососудистых, отечных и психоэмоциональных симптомов ПМС, что определяет «Эвику», как препарат выбора у пациенток с ПМС, выраженной вегетососудистой и психоэмоциональной симптоматики.
Premenstrual syndrome (PMS) is a pathological symptom complex that significantly reduces a woman's quality of life. Despite the fact that the etiology and pathogenesis have not been studied enough to date, the directions in diagnosis, treatment and prevention that need to be followed have been identified. Treatment of PMS should be differentiated, taking into account the state of a woman's general and reproductive health, concomitant diseases, the severity of PMS, the tolerability of therapy, etc. Currently, herbal medicines are increasingly used in the treatment of PMS. The aim of the study was to learn the effectiveness of the herbal medicine "Eviсa" in the treatment of mild and moderate PMS. The results obtained indicate the effectiveness of this drug in eliminating vegetativevascular, edematous and psychoemotional symptoms of PMS, which defines "Evica" as the medication of choice in patients with PMS, vegetativevascular and psychoemotional symptoms.
NEW ORIGINAL DRUG ROSEOFUNGIN-AS, OINTMENT 2%
Authors: САДАНОВ А.К. , БЕРЕЗИН В.Э. , КУЛМАГАМБЕТОВ И.Р. , ТРЕНОЖНИКОВА Л.П. , БАЛГИМБАЕВА А.С. 
Published: December 2021

В статье приводятся сведения о разработке нового отечественного противогрибкового препарата «Розеофунгин-АС, мазь 2%» для наружного применения на основе оригинального природного полиенового антибиотика розеофунгина. Приводятся данные о продуценте антибиотика, процессе его биосинтеза и получения, его физико-химических свойствах и химической структуре, рассматриваются его антифунгальные и антивирусные свойства, механизм его действия, а также основные этапы разработки противогрибкового препарата - доклинические и I, II и III фазы клинических исследований.
This paper provides the information on the development of new domestic antifungal drug Roseofungin-AS, ointment 2% for external use based on the original natural polyene antibiotic roseofungin. Data on the antibiotic producer, the process of its biosynthesis and production, its physicochemical properties and chemical structure are presented, its antifungal and antiviral properties, the mechanism of action as well as the main stages of the antifungal drug development including preclinical and phase I, II, III clinical trials are discussed.
Mechanical Properties of Polyester Toughened with Nano-Silica
Authors: Kaka Diyar , Fatah Roma A. , Gharib Parzhin , Mustafa Ahmad 
Published: December 2021

The fabrication of nanocomposites has played role to the development of the nanotechnology and the technology of advanced composite materials. Thermoset polymers are used in engineering applications widely. Their mechanical properties can be change with adding particles. The mechanism of toughening polymers has been suggested recently by reinforcing well dispersed particles to the plain polymer. Nano-silica particles were added to thermoset polymer of polyester to evaluate their influence on the mechanical properties of the toughened polymer using both experimental and numerical methods. The Representative Volume Element (RVE) approach, which employs finite element models, has been developed to achieve that aim numerically for various types of nano-particle reinforcement ratios. In each case, the stiffness has been calculated with using the equivalent homogeneous material concept. Experimentally, toughened thermoset polymers of polyester reinforced with nano-silica were prepared with different particle content ratio. Several tests were conducted on the nanocomposite, and it was observed increasing nano-silica ratio caused increase in Young’s modulus and decrease in ductility.
Modernidade, cidade e escola: o contexto sociocultural da virada do século XIX para o XX
Authors: Zattoni Andreia Cristina Borges Rela , Guimarães Maria de Fátima , Medeiros Daniel Amaro Cirino 
Published: December 2021

O presente artigo, aborda as escolas isoladas que deram origem ao Grupo Escolar Dr. Jorge Tibiriçá, entre fins do século XIX e início do XX, em Bragança. Privilegiamos esse período porque ele é matizado, em termos mundiais e também locais – guardadas as devidas proporções –, por bruscas e muitas transformações sociais, políticas, econômicas e culturais, ancoradas no processo crescente e simultâneo de industrialização, aumento populacional e urbanização do país, em franca relação com as ações destinadas à esfera da educação.

Palavras-chave: Grupo Escolar Dr. Jorge Tibiriçá; Educação ; Modernidade;
Reconstructing the great Benga cyclone of 1737
Authors: SARMA A K. SEN 
Published: December 2021

Having established that the figure of 300,000 quoted as the human casualty in the legendary south of 1737 was a implant (Sen Sarma 1994) and the simultaneous earthquake a myth (Sen Sarma 1993, Bilham, 1994) it was necessary to freshly evaluate that storm as to its severity and destructive impact.
The strength of0 storm was assessed by using the reported surge of 40 ft as the output in Ghosh’s (1977) surge computing scheme and arriving at the required input p. The probable track of the storm was reconstructed with the help of an analogue. The likely area inundated by 'significant' surge was demarcated by analogy with 1970 Bangladesh storm (Frank and Husain 1971). The affected population of that area was estimated from the decadal figures for Bengal area going backward from recent times to 1801, Finally, the number of lives lost was inferred from the available data on the mortality ratio in the Andhra cyclone of 1977.
It is estimated that the cyclone of 17.37 was a T 7 storm and had taken 35,000 lives (the error margin being 10,000 on either side of that figure).
Daily rainfall forecasts through a quantitative precipitation forecasting (QPF) model over Thiruvananthapuram and Madras areas for the monsoons of 1992
Authors: RAJ Y.E. A. , SARKAR JAYANTA , RAMAKRISHNAN B. 
Published: December 2021

Quantitative precipitation forecasting (QPF) of daily rainfall of Thiruvananthapuram and Madras for June-September and October-December respectively for the year 1992 has been attempted. A mathematical model of QPF based on the concept of conservation of specific humidity and with upper air data of a network of stations as the data input has been employed. Nearly 66% and 72% correct forecasts were realised respectively for the two stations. Scope for further refinement has been briefly discussed.