bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervening in a Messy Reality: A Case of Interorganizational Collaboration in Talent Development Within the Danish Sport System
Authors: Mathorne Ole Winthereik , Stambulova Natalia , Henriksen Kristoffer 
Published: December 2021

The overall aim of this paper is to share our experiences in development, implementation, and evaluation of an intervention designed for establishing interorganizational collaboration in talent development between a Danish sports club, a municipality, and a federation. Yet, despite a neat plan, we faced several challenges in what turned out to be a less successful intervention. The account is based on the first author’s field notes, informal interviews, and intervention debriefings. The professional philosophy of the research team was informed by the holistic ecological approach and an empowerment approach. We used the pyramid model for optimizing interorganizational collaboration in talent development as a framework to design and guide the 7-month intervention that included four workshops covering (a) initiation: building relationships; (b) exploration: foundation for the shared philosophy; (c) clarification: negotiating values and strategy; and (d) implementation: from talk to action. However, challenges (e.g., resignations of key stakeholders) led to program adjustments and, ultimately, termination. This paper shows the nuances of a less successful intervention, which can help practitioners plan and carry out better interventions in the future. Despite the challenges faced here, we still deem the pyramid model for optimizing interorganizational collaboration in talent development a valuable framework for practitioners working at an interorganizational level.
Ancient creatures of Hungary: Bringing the animals to life
Authors: Pecsics* Tibor 
Published: December 2021

ABSTRACT
The first trace fossils in Hungary, dinosaur footprints, were found in the coal mines of the Mecsek Mountains. The footprints belonged to small theropod dinosaurs. The first fossil bones of vertebrate animals from present-day Hungary were found in 2000 in the mountainous region of Bakony. Numerous taxa have been collected from the locality of Iharkút. These fossils represent a diverse fauna (including fishes, amphibians, turtles, lizards, crocodilians, dinosaurs, birds, and pterosaurs) that lived between 85.8 and 83.5 m.y. ago in the Santonian Age during the Late Cretaceous period. Paleoart can depict these fossil remains in an engaging way to help inform the public about the ancient creatures of Hungary. This chapter provides an overview of how the Mesozoic vertebrates from Hungary have been reconstructed for scientists and the public.
Effectiveness and safety of manual acupuncture therapy in patients with post-stroke depression: a protocol for a systematic review and meta-analysis
Authors: Liu Wei , Rao Chang , Zhao Qi , Du Yuzheng , Nan Xi , Li Zefang , Yin Chunsheng 
Published: December 2021

IntroductionAcupuncture is widely used on the rehabilitation of stroke survivors, including hemiplegia, constipation, emotional disorders and so on. Although the effectiveness of manual acupuncture therapy on post-stroke depression (PSD) has been confirmed by multiple randomised controlled trials, there were few meta-analyses focused on the connection between different techniques, durations or other detailed operations of manual acupuncture and their effectiveness of improving the depression severity and quality of life for patients with PSD.Methods and analysisA systematic search will be performed on English databases (PubMed, the Cochrane Library, Medline and Embase), Chinese databases (China National Knowledge Infrastructure, WanFang Data, VIP and Chinese biomedical databases) and Japanese databases (Japan Science and Technology Agency and CiNii). The retrieval time limit will be from the establishment of the database to November 2020. Two researchers will independently screen the literature works, extract data and evaluate the quality of the included studies. Meta-analysis will be conducted by using STATA V.14.0 and Review Manager V.5.3.Ethics and disseminationThe results of this meta-analysis will be disseminated through publication in peer-reviewed journals or conference presentations. The data used in this meta-analysis will not contain individual patient data; therefore, ethical approval is not required.PROSPERO registration numberCRD42020222825.
Study protocol for a randomised clinical trial of a decision aid and values clarification method for parents of a fetus or neonate diagnosed with a life-threatening congenital heart defect
Authors: Delaney Rebecca K , Pinto Nelangi M , Ozanne Elissa M , Stark Louisa A , Pershing Mandy L , Thorpe Alistair , Witteman Holly O , Thokala Praveen , Lambert Linda M , Hansen Lisa M , Greene Tom H , Fagerlin Angela 
Published: December 2021

IntroductionParents who receive the diagnosis of a life-threatening, complex heart defect in their fetus or neonate face a difficult choice between pursuing termination (for fetal diagnoses), palliative care or complex surgical interventions. Shared decision making (SDM) is recommended in clinical contexts where there is clinical equipoise. SDM can be facilitated by decision aids. The International Patient Decision Aids Standards collaboration recommends the inclusion of values clarification methods (VCMs), yet little evidence exists concerning the incremental impact of VCMs on patient or surrogate decision making. This protocol describes a randomised clinical trial to evaluate the effect of a decision aid (with and without a VCM) on parental mental health and decision making within a clinical encounter.Methods and analysisParents who have a fetus or neonate diagnosed with one of six complex congenital heart defects at a single tertiary centre will be recruited. Data collection for the prospective observational control group was conducted September 2018 to December 2020 (N=35) and data collection for two intervention groups is ongoing (began October 2020). At least 100 participants will be randomised 1:1 to two intervention groups (decision aid only vs decision aid with VCM). For the intervention groups, data will be collected at four time points: (1) at diagnosis, (2) postreceipt of decision aid, (3) postdecision and (4) 3 months postdecision. Data collection for the control group was the same, except they did not receive a survey at time 2. Linear mixed effects models will assess differences between study arms in distress (primary outcome), grief and decision quality (secondary outcomes) at 3-month post-treatment decision.Ethics and disseminationThis study was approved by the University of Utah Institutional Review Board. Study findings have and will continue to be presented at national conferences and within scientific research journals.Trial registration numberNCT04437069(Pre-results).
Discordance between family report and clinical assessment of suicide attempts: a prospective study from the emergency department
Authors: Zheng Yue , Zhang Haiyin , Fan Qing 
Published: December 2021

BackgroundDeveloping accurate identification methods for individuals with suicide attempts and providing them with follow-up care and supports can be a vital component of all comprehensive suicide prevention strategies. However, because of the difficulties concerning one’s intentions behind injurious behaviour, identifying suicide attempts is a challenge for families and clinicians.AimsThe aim of this study was to investigate the differences between family report and clinical assessment for suicide attempts in the emergency department (ED).MethodsA total of 148 patients with suspected suicide attempts (SSAs) and 148 family caregivers in the ED were enrolled. The suicide risk module of the Chinese version of the MINI International Neuropsychiatric Interview and the self-report measure were used to assess those with SSA’s suicidal behaviours. The Family Adaptability and Cohesion Evaluation Scales and semi-structured interviews were used to investigate the characteristics of suicide risk and demographics of patients with SSA, as well as the rate and influencing factors of omitted suicide attempts reported by family caregivers.ResultsThe underreporting rate for family reported suicide attempts in the ED was 69.0%. The suicide attempts group indicated lower mean scores on perceptions of family resources, adaptability and cohesion. Patients' suicide risk rating (OR=0.152, 95% CI: 0.037 to 0.620, p=0.009), adult-children relationship (OR=5.037, 95% CI: 1.478 to 17.167, p=0.010) and caregiver’s age (OR=0.279, 95% CI: 0.103 to 0.757, p=0.012) might be associated with underreporting by families. If patients committed suicide attempts through a falling injury or medication overdose, their families may have misreported the suicide attempt.ConclusionsThe discordance of suicide attempt records between family report and clinical assessment reveals the limitations of family self-reports when identifying suicide attempts. Interviews and observations, together with information from certain diagnoses, should be combined to accurately identify suicide attempters in the ED.
Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival
Authors: Shah Manish A , Cunningham David , Metges Jean-Philippe , Van Cutsem Eric , Wainberg Zev , Elboudwarej Emon , Lin Kai-Wen , Turner Scott , Zavodovskaya Marianna , Inzunza David , Liu Jinfeng , Patterson Scott D , Zhou Jingzhu , He Jing , Thai Dung , Bhargava Pankaj , Brachmann Carrie Baker , Cantenacci Daniel V T 
Published: December 2021

BackgroundMatrix metalloproteinase-9 (MMP9) selectively cleaves extracellular matrix proteins contributing to tumor growth and an immunosuppressive microenvironment. This study evaluated andecaliximab (ADX), an inhibitor of MMP9, in combination with nivolumab (NIVO), for the treatment of advanced gastric cancer.MethodsPhase 2, open-label, randomized multicenter study evaluating the efficacy, safety, and pharmacodynamics of ADX+NIVO versus NIVO in patients with pretreated metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. The primary endpoint was objective response rate (ORR). Secondary endpoints included progression-free survival (PFS), overall survival (OS), and adverse events (AEs). We explored the correlation of efficacy outcomes with biomarkers.Results144 patients were randomized; 141 were treated: 81% white, 69% male, median age was 61 years in the ADX+NIVO group and 62 years in the NIVO-alone group. The ORR was 10% (95% CI 4 to 19) in the ADX+NIVO group and 7% (95% CI 2 to 16) in the NIVO-alone group (OR: 1.5 (95% CI 0.4 to 6.1; p=0.8)). There was no response or survival benefit associated with adding ADX. AE rates were comparable in both treatment groups; the most common AEs were fatigue, decreased appetite, nausea, and vomiting. Programmed cell death ligand 1, interferon-γ (IFN), and intratumoral CD8+ cell density were not associated with treatment response or survival. The gene signature most correlated with shorter survival was the epithelial-to-mesenchymal gene signature; high transforming growth factor (TGF)-β fibrosis score was negatively associated with OS (p=0.036). Gene expression analysis of baseline tumors comparing long-(1+ years) and short-term (<1 year) survivors showed that GRB7 was associated with survival beyond 1 year. Human epidermal growth factor receptor 2 (HER2)-positive disease was associated with significantly longer survival (p=0.0077). Median tumor mutation burden (TMB) was 2.01; patients with TMB ≥median had longer survival (p=0.0025) and improved PFS (p=0.016). Based on a model accounting for TMB, TGF-β fibrosis, and HER2, TMB was the main driver of survival in this patient population.ConclusionCombination of ADX+NIVO had a favorable safety profile but did not improve efficacy compared with NIVO alone in patients with pretreated metastatic gastric or GEJ adenocarcinoma. HER2 positivity, higher TMB or GRB7, and lower TGF-β were associated with improved outcomes.Trial registration numberNCT02864381or GS-US-296–-2013.
Large steps in inverse rendering of geometry
Authors: Nicolet Baptiste , Jacobson Alec , Jakob Wenzel 
Published: December 2021

Inverse reconstruction from images is a central problem in many scientific and engineering disciplines. Recent progress on differentiable rendering has led to methods that can efficiently differentiate the full process of image formation with respect to millions of parameters to solve such problems via gradient-based optimization.
At the same time, the availability of cheap derivatives does not necessarily make an inverse problem easy to solve. Mesh-based representations remain a particular source of irritation: an adverse gradient step involving vertex positions could turn parts of the mesh inside-out, introduce numerous local self-intersections, or lead to inadequate usage of the vertex budget due to distortion. These types of issues are often irrecoverable in the sense that subsequent optimization steps will further exacerbate them. In other words, the optimization lacks robustness due to an objective function with substantial non-convexity.
Such robustness issues are commonly mitigated by imposing additional regularization, typically in the form of Laplacian energies that quantify and improve the smoothness of the current iterate. However, regularization introduces its own set of problems: solutions must now compromise between solving the problem and being smooth. Furthermore, gradient steps involving a Laplacian energy resemble Jacobi's iterative method for solving linear equations that is known for its exceptionally slow convergence.
We propose a simple and practical alternative that casts differentiable rendering into the framework of preconditioned gradient descent. Our pre-conditioner biases gradient steps towards smooth solutions without requiring the final solution to be smooth. In contrast to Jacobi-style iteration, each gradient step propagates information among all variables, enabling convergence using fewer and larger steps.
Our method is not restricted to meshes and can also accelerate the reconstruction of other representations, where smooth solutions are generally expected. We demonstrate its superior performance in the context of geometric optimization and texture reconstruction.
Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology
Authors:   The AACR Pathology Task Force, Compton Carolyn C. , De Marzo Angelo M. , Debnath Jayanta , Eaton Keith D. , Elenitoba-Johnson Kojo , Fiorentino Michelangelo , French Christopher A. , Fuchs Thomas J. , Giangaspero Felice , Huang Jiaoti , Iafrate A. John , Ittmann Michael M. , Jensen Roy A. , Kim Annette S. , Loda Massimo , Lorenz Robin G. , Lotan Tamara L. , Maitra Anirban , Meijer Gerrit A. , Mitchell Richard N. , Parwani Anil V. , Pezzella Francesco , Pikarsky Eli , Reis-Filho Jorge S. , Richardson Andrea L. , Rubin Mark A. , True Lawrence D. 
Published: December 2021

Abstract
Every profession has an essential, behind-the-scenes component without which it cannot function. Medicine is no exception. Pathologists are one of medicine's group of specialists whose work as diagnosticians is critical for patient care. This article describes the multifaceted role that pathologists play in oncology practice and cancer research. To do so, we will highlight the role of pathologists in a typical “day-in-the-life” of a patient's journey in cancer care. Clinicians, clinical trialists, radiologists, researchers, and pathologists, all work together to provide optimal, multidisciplinary care for patients with cancer.
Periodic Repolarization Dynamics Identifies ICD Responders in Nonischemic Cardiomyopathy: A DANISH Substudy
Authors: Boas Rune , Sappler Nikolay , von Stülpnagel Lukas , Klemm Mathias , Dixen Ulrik , Thune Jens Jakob , Pehrson Steen , Køber Lars , Nielsen Jens C. , Videbæk Lars , Haarbo Jens , Korup Eva , Bruun Niels Eske , Brandes Axel , Eiskjær Hans , Thøgersen Anna M. , Philbert Berit T. , Svendsen Jesper Hastrup , Tfelt-Hansen Jacob , Bauer Axel , Rizas Konstantinos D. 
Published: December 2021

Background:
Identification of patients with nonischemic cardiomyopathy who may benefit from prophylactic implantation of a cardioverter-defibrillator. We hypothesized that periodic repolarization dynamics (PRD), a marker of repolarization instability associated with sympathetic activity, could be used to identify patients who will benefit from prophylactic implantable cardioverter defibrillator (ICD) implantation.

Methods:

We performed a post hoc analysis of DANISH (Danish ICD Study in Patients With Dilated Cardiomyopathy), in which patients with nonischemic cardiomyopathy, left ventricular ejection fraction (LVEF) ≤35%, and elevated NT-proBNP (N-terminal probrain natriuretic peptides) were randomized to ICD implantation or control group. Patients were included in the PRD substudy if they had a 24-hour Holter monitor recording at baseline with technically acceptable ECG signals during the night hours (00:00–06:00). PRD was assessed using wavelet analysis according to previously validated methods. The primary end point was all-cause mortality. Cox regression models were adjusted for age, sex, NT-proBNP, estimated glomerular filtration rate, LVEF, atrial fibrillation, ventricular pacing, diabetes, cardiac resynchronization therapy, and mean heart rate. We proposed PRD ≥10 deg
2
as an exploratory cut-off value for ICD implantation.

Results:

A total of 748 of the 1116 patients in DANISH qualified for the PRD substudy. During a mean follow-up period of 5.1±2.0 years, 82 of 385 patients died in the ICD group and 85 of 363 patients died in the control group (
P
=0.40). In Cox regression analysis, PRD was independently associated with mortality (hazard ratio [HR], 1.28 [95% CI, 1.09–1.50] per SD increase;
P
=0.003). PRD was significantly associated with mortality in the control group (HR, 1.51 [95% CI, 1.25–1.81];
P
<0.001) but not in the ICD group (HR, 1.04 [95% CI, 0.83–1.54];
P
=0.71). There was a significant interaction between PRD and the effect of ICD implantation on mortality (
P
=0.008), with patients with higher PRD having greater benefit in terms of mortality reduction. ICD implantation was associated with an absolute mortality reduction of 17.5% in the 280 patients with PRD ≥10 deg
2
(HR, 0.54 [95% CI, 0.34–0.84];
P
=0.006; number needed to treat=6), but not in the 468 patients with PRD <10 deg
2
(HR, 1.17 [95% CI, 0.77–1.78];
P
=0.46;
P
for interaction=0.01).

Conclusions:
Increased PRD identified patients with nonischemic cardiomyopathy in whom prophylactic ICD implantation led to significant mortality reduction.
Heightened Cardiovascular Risk in Hypertension Associated With Renin‐Independent Aldosteronism Versus Renin‐Dependent Aldosteronism: A Collaborative Study
Authors: Hu Jinbo , Shen Hang , Huo Peiqi , Yang Jun , Fuller Peter J , Wang Kanran , Yang Yi , Ma Linqiang , Cheng Qingfeng , Gong Lilin , He Wenwen , Luo Ting , Mei Mei , Wang Yue , Du Zhipeng , Luo Rong , Cai Jun , Li Qifu , Song Ying , Yang Shumin 
Published: December 2021

Background
While both renin‐dependent and renin‐independent aldosterone secretion contribute to aldosteronism, their relative associations with cardiovascular disease (CVD) risk has not been investigated.

Methods and Results

A total of 2909 participants from the FOS (Framingham Offspring Study) with baseline, serum aldosterone concentration, and plasma renin concentration who attended the sixth examination cycle and were followed up until 2014 and who were free of CVD were included. We further recruited 2612 hypertensive participants from the CONPASS (Chongqing Primary Aldosteronism Study). Captopril challenge test was performed to confirm renin‐dependent or ‐independent aldosteronism in CONPASS. Among 1433 hypertensive subjects of FOS, when compared with those with serum aldosterone concentration <10 ng dL
−1
(normal aldosterone), participants who had serum aldosterone concentration ≥10 ng dL
−1
and plasma renin concentration ≤15 mIU L
−1
(identified as renin‐independent aldosteronism) showed a higher risk of CVD (hazard ratio, 1.40 [95% CI, 1.08–1.82]), while those who had serum aldosterone concentration ≥10 ng dL
−1
and plasma renin concentration >15 mIU L
−1
(identified as renin‐dependent aldosteronism) showed an unchanged CVD risk. In CONPASS, renin‐independent aldosteronism carried a significantly higher risk of CVD than normal aldosterone (odds ratio, 2.57 [95% CI, 1.13–5.86]), while the CVD risk remained unchanged in renin‐dependent aldosteronism. Elevation of the urinary potassium‐to‐sodium excretion ratio, reflective of mineralocorticoid receptor activity, was only observed in participants with renin‐independent aldosteronism.

Conclusions
Among patients with hypertension, renin‐independent aldosteronism is more closely associated with CVD risk than renin‐dependent aldosteronism.
Angiotensin‐Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID‐19
Authors: Pan Michael , Vasbinder Alexi , Anderson Elizabeth , Catalan Toniemarie , Shadid Husam R. , Berlin Hanna , Padalia Kishan , O’Hayer Patrick , Meloche Chelsea , Azam Tariq U. , Khaleel Ibrahim , Michaud Erinleigh , Blakely Pennelope , Bitar Abbas , Huang Yiyuan , Zhao Lili , Pop‐Busui Rodica , Loosen Sven H. , Chalkias Athanasios , Tacke Frank , Giamarellos‐Bourboulis Evangelos J. , Reiser Jochen , Eugen‐Olsen Jesper , Hayek Salim S. ,   the ISIC Group
Published: December 2021

Background
Use of angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) is thought to affect COVID‐19 through modulating levels of angiotensin‐converting enzyme 2, the cell entry receptor for SARS‐CoV2. We sought to assess the association between ACEi/ARB, biomarkers of inflammation, and outcomes in patients hospitalized for COVID‐19.

Methods and Results
We leveraged the ISIC (International Study of Inflammation in COVID‐19), identified patients admitted for symptomatic COVID‐19 between February 1, 2020 and June 1, 2021 for COVID‐19, and examined the association between in‐hospital ACEi/ARB use and all‐cause death, need for ventilation, and need for dialysis. We estimated the causal effect of ACEi/ARB on the composite outcomes using marginal structural models accounting for serial blood pressure and serum creatinine measures. Of 2044 patients in ISIC, 1686 patients met inclusion criteria, of whom 398 (23.6%) patients who were previously on ACEi/ARB received at least 1 dose during their hospitalization for COVID‐19. There were 215 deaths, 407 patients requiring mechanical ventilation, and 124 patients who required dialysis during their hospitalization. Prior ACEi/ARB use was associated with lower levels of soluble urokinase plasminogen activator receptor and C‐reactive protein. In multivariable analysis, in‐hospital ACEi/ARB use was associated with a lower risk of the composite outcome of in‐hospital death, mechanical ventilation, or dialysis (adjusted hazard ratio 0.49, 95% CI [0.36–0.65]).

Conclusions
In patients hospitalized for COVID‐19, ACEi/ARB use was associated with lower levels of inflammation and lower risk of in‐hospital outcomes. Clinical trials will define the role of ACEi/ARB in the treatment of COVID‐19.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04818866.