bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference Ranges of Iron Profiles in Apparently Healthy Elderly in Sokoto, Nigeria
Authors: Uchechukwu Onuigwe, Festus , Chitogu Ibeh, Nancy , Ifechukwudebelu Amilo, Grace 
Published: September 2021

Background: Iron is an important micronutrient in the body, lead to anaemia, frailty and cognitive disorders in the elderly when deficient.
Aim: This study was aimed to determine reference values of iron profile in apparently healthy elderly persons in Sokoto and compared with the local reference values.
Study Design: This was a comparative study
Duration of Study: The study lasted for a period of one year between January to December, 2020.
Methodology: This was a comparative study involving 105 apparently healthy elderly persons aged 60 years and above in Sokoto metropolis. Serum iron and total-iron binding capacity (TIBC) were determined using Iron Ferrozine method. Serum ferritin, Serum transferrin (Tf) and Serum Transferrin Receptors (sTfR) were assayed using enzyme-linked immunosorbent assay (ELISA). Transferrin Saturation (TS) and Serum Transferrin Receptors ferritin log (sTfR/FL) was calculated. Data were expressed as percentiles, mean and standard deviation and analysed using t-test and one way ANOVA.
Results: The study established reference ranges of Serum iron,TIBC, Serum ferritin, Tf, sTfR, TS and sTfR/FL was calculated. in Sokoto. The study showed that iron and ferritin have high reference ranges than the local values in Sokoto. The local values for TIBC, ferritin, sTfR, TS and sTfR/FL were not available. Mean Ferritin (µg/L), sTfR (ng/L) and sTfR/Fl the test subjects were significantly higher in males than females in Sokoto (p=0.026), (p= 0.001), (p=0.044) and (p= 0.003) respectively. Iron, ferritin and TS increased as the BMI was increasing (p=<0.001).
Conclusion: In conclusion, normal reference values obtained in this study notably vary with the local reference ranges used in the Sokoto metropolis. There is a need for each locality to have separate reference ranges for the elderly for their proper diagnosis and management of iron related disorders.
Bioinspired Intrinsic Versatile Hydrogel Fabricated by Amyloidal Toxin Simulant‐Based Nanofibrous Assemblies for Accelerated Diabetic Wound Healing
Authors: Xuan Qize , Jiang Feng , Dong Hao , Zhang Wenxue , Zhang Feiyang , Ma Tonghao , Zhuang Jiafeng , Yu Jinlong , Wang Yibing , Shen Hao , Chen Chao , Wang Ping 
Published: September 2021

AbstractPersistent microbial infection and decreased neovascularization are common issues associated with diabetic wound treatment. Hydrogel dressings that offer intrinsic antibacterial and angiogenesis‐inducing may substantially avoid the use of antibiotics or angiogenic agents. Herein, a versatile hydrogel is fabricated using an amyloid‐derived toxin simulant (Fmoc‐LFKFFK‐NH2, FLN) as building blocks, inspired by the defense strategy of Staphylococcus aureus (S. aureus). The simulant assemblies of the hydrogel function as both matrix components and functional elements for diabetic wound treatment. The hydrogel undergoes quick assembly from random monomers to nanofibrils with abundant b‐sheet driven by multiple non‐covalent interactions. The developed hydrogel demonstrates excellent biocompatibility and accelerates angiogenesis via hypoxia‐inducible factor 1α (HIF‐1α) and vascular endothelial growth factor A (VEGFA) signaling as a consequence of its amyloidal structure. The simulant‐based nanofibrils endow the hydrogel with broad‐spectrum antibacterial activity dominated by a membrane‐disruption mechanism. In addition, the hydrogel exhibits excellent performance compared with the commercial hydrogel Prontosan in accelerating wound healing of diabetic mice infected with methicillin‐resistant S. aureus (MRSA). This study highlights the fabrication of a single component and versatile hydrogel platform, thereby avoiding the drug‐related side effects and complicated preparations and demonstrating its profound potential as a clinical dressing for the management of microbe‐infected diabetic wounds.
Bio‐derived nanosilica‐anchored Cu(II)‐organoselenium complex as an efficient retrievable catalyst for alcohol oxidation
Authors: Gogoi Rajjyoti , Borah Geetika 
Published: September 2021

AbstractA new copper(II) complex supported onto rice‐husk‐derived nanosilica was prepared from 2,6‐bis((phenylselanyl)methyl)pyridine, salicylaldehyde and copper acetate monohydrate, Cu(OAc)2·H2O. The as‐synthesized complex Cu(II)SeNSe@imine‐nanoSiO2 (Complex I) was extensively characterized with FT‐IR, powder XRD, SEM‐EDX, solid‐state UV‐Vis, ESR, XPS, TGA and BET surface area analysis. The catalytic activity of the complex was explored for alcohol oxidation reactions using H2O2 as oxidant and acetonitrile as solvent. For comparison, we have also prepared an analogous homogeneous catalyst (Complex II) and characterized it with FT‐IR, UV‐Vis, LC‐MS and ESR analyses. Its catalytic activity was also screened to the same reaction. The immobilized catalyst showed better efficiency with 75%–95% isolated yield compared with the homogeneous one for alcohol oxidation with at least five times recyclability without profound loss in activity.
The use of sludge as a micronutrient for the improvement of biogas production from seaweed: the integration of two sources of environmental concern to bring new opportunities
Authors: Rezaei Mostafa , Ebrahimi‐Nik Mohammadali , Tedesco Silvia , Zeynali Reyhaneh 
Published: September 2021

AbstractLarge quantities of seaweed in marine environments and coastal areas can cause serious hygienic and environmental problems. Anaerobic digestion (AD) could provide a solution and could also be useful for the production of bioenergy and fertilizer. However, the AD of algae biomass has some limitations and further work is required on the process. To increase the efficiency of the process, batches of 350 mL feedstock containing seaweed biomass (Sargassum sp.), inoculum, and different dosages of sludge from drinking water treatment (DWTS) as a micronutrient source to improve biogas production were digested in a 500 mL glass reactor and under mesophilic conditions, leading to significantly enhanced methane production. The highest methane yield (199 NmL g−1 VS) was observed when 6 mg L−1 DWTS was added, which showed a 30% improvement compared with the control digester and accounted for a 249.4 kWh increase in net energy per ton. The biodegradability index also increased by 10% compared with the control after the addition of DWTS. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Connection to nature and sustainability in small‐ and medium‐sized environmental organizations: A dynamic strategic thinking approach
Authors: Karami Azhdar , Gorzynski Robert Anthony 
Published: September 2021

AbstractStrategic thinking has evolved from a concept predominantly based on analysis, closely integrated with strategic planning, to a broader mindset, yet it remains strongly ‘head based’. The aim of this paper is to explore a context where a broader, more holistic perspective exists, focused on the connection of small‐ and medium‐sized environmental organizations with the natural world, why and how this relationship influences strategic thinking and how it enables organizations to leverage limited resources. The research methodology reflects the rationale that a holistic perspective of strategic thinking is best understood by adopting an interpretivist research philosophy, using an inductive, ethnographic approach, focused on interpreting deep, rich layers of meaning within participant data to inform new theory and existing practice. The triangulated multi‐method approach, within an embedded case study setting, comprised 38 individual interviews and 4 workshops (group interviews, participant observation) drawn from 29 organizations across the United Kingdom. The findings indicate that the strategic thinking process is emergent, complex, interconnected, informal and is embedded within pivotal places alongside governance, strategic planning and other key processes. Participants are driven by a strong embodied personal connection with nature, extending well beyond the cognitive dimension (mind) to a diverse range of sensibilities (heart, body and spirit) and share an experiential process of connection that binds them together as purpose‐ and value‐driven organizations. The implication is that a connection to nature underpins all aspects of the strategic processes within participant organizations and is fundamentally important to decision‐making at all levels, both strategic and implementational.
Identification of a novel six‐gene signature with potential prognostic and therapeutic value in cervical cancer
Authors: Qu Xinyu , Shi Zhiwen , Guo Jingjing , Guo Chenyan , Qiu Junjun , Hua Keqin 
Published: September 2021

AbstractIntroductionCervical cancer has high mortality, high recurrence and poor prognosis. Although prognostic biomarkers such as clinicopathological features have been proposed, their accuracy and precision are far from satisfactory. Therefore, novel biomarkers are urgently needed for disease surveillance, prognosis prediction and treatment selection.MaterialsDifferentially expressed genes (DEGs) between cervical cancer and normal tissues from three microarray datasets extracted from the Gene Expression Omnibus platform were identified and screened. Based on these DEGs, a six‐gene prognostic signature was constructed using cervical squamous cell carcinoma and endocervical adenocarcinoma data from The Cancer Genome Atlas. Next, the molecular functions and related pathways of the six genes were investigated through gene set enrichment analysis and co‐expression analysis. Additionally, immunophenoscore analysis and the QuartataWeb Server were employed to explore the therapeutic value of the six‐gene signature.ResultsWe discovered 178 overlapping DEGs in three microarray datasets and established a six‐gene (APOC1, GLTP, ISG20, SPP1, SLC24A3 and UPP1) prognostic signature with stable and excellent performance in predicting overall survival in different subgroups. Intriguingly, the six‐gene signature was closely associated with the immune response and tumour immune microenvironment. The six‐gene signature might be used for predicting response to immune checkpoint inhibitors (ICIs) and the six genes may serve as new drug targets for cervical cancer.ConclusionOur study established a novel six‐gene (APOC1, GLTP, ISG20, SPP1, SLC24A3 and UPP1) signature that was closely associated with the immune response and tumour immune microenvironment. The six‐gene signature was indicative of aggressive features of cervical cancer and therefore might serve as a promising biomarker for predicting not only overall survival but also ICI treatment effectiveness. Moreover, three genes (UPP1, ISG20 and GLTP) within the six‐gene signature have the potential to become novel drug targets.
Coronary bypass graft surgery accentuates proximal coronary disease progression!
Authors: Okuya Yoshiyuki , Moussa Issam D. 
Published: September 2021

Key Points
Optical coherence tomography imaging demonstrated that patients with prior coronary artery bypass graft surgery (CABG) to the left coronary circulation have greater amount of calcium in the distal left main coronary artery and proximal segments of the left anterior descending and left circumflex artery compared to those without prior CABG.
Atherosclerotic disease progression in coronary segments proximal to bypass grafts should be considered in decision‐making for patients undergoing CABG.
Further studies are needed to better elucidate the mechanisms and implications of atherosclerotic disease progression in coronary segments proximal to bypass grafts.
Ultrafast reaction‐sintering of grain size‐controlled titanium niobate from TiO2 and Nb2O5
Authors: G. Oliveira Vinícius S. , S. Falk Gilberto , Hotza Dachamir , Gómez González Sergio Yesid 
Published: September 2021

AbstractTiNb2O7 is a promising alternative to graphite anodes currently employed in lithium‐ion batteries. The material offers a high specific capacity, good cycling stability, and better safety characteristics. The solid‐state reaction between TiO2 and Nb2O5 is the most straightforward synthesis route to prepare TiNb2O7. It has only been documented so far to be conducted at long periods of sintering time (>10 h). In this work, we propose a fast‐firing approach to the solid‐state synthesis, which yields TiNb2O7 in less than 2 min of furnace holding time, starting from tape‐cast titania (d50 = 0.26 μm) and niobia (d50 = 0.967 μm) green compacts. Besides significantly reducing processing time, fast‐firing enabled the hindering of grain growth, producing a material with grain size ∼0.5 μm (holding time of 2 min) and ∼1 μm (5–10 min).
CPP11sort: A parallel quicksort based on C++ threading
Authors: Langr Daniel , Schovánková Klára 
Published: September 2021

SummaryA new efficient implementation of the multithreaded quicksort algorithm called CPP11sort is presented. This implementation is built exclusively upon the threading primitives of the C++ programming language itself. The performance of CPP11sort is evaluated and compared with its mainstream competitors provided by GNU, Intel, and Microsoft. It is shown that out of the considered implementations, CPP11sort mostly yields the shortest sorting times and is the only one that is portable to any conforming C++ implementation without a need of external libraries or nonstandard compiler extensions. The experimental evaluation with various input data distributions resulted in parallel speedup between 16.1 and 44.2 on a 56‐core server and between 6.8 and 14.5 on a 10‐core workstation with enabled hyperthreading.
A comparison of completion and recovery rates between first‐line protocol‐based cognitive behavioural therapy and non‐manualized relational therapies within a UK psychological service
Authors: Leonidaki Venetia , Constantinou Matthew P. 
Published: September 2021

AbstractThis study compares completion and recovery rates between protocol‐based cognitive behavioural therapy (CBT), offered as a first‐line therapy for common mental health problems as per national guidelines, and relational therapies (RTs), scarcely provided in the English Improving Access to Psychological Therapies (IAPT) programme. This is a non‐randomized, naturalistic study in a treatment‐seeking community sample (n = 708). RTs consist of brief psychodynamic and relational integrative therapy. Completion rates relied on clinicians' coding and recovery rates were calculated based on the Patient Health Questionnaires‐9 and the Generalized Anxiety Disorder‐7. Doubly robust regression analysis was used to control both the treatment allocation and outcome variables for pretreatment differences between the intervention groups. Significantly more RT clients completed treatment compared with CBT clients. No significant differences in recovery rates between CBT and RTs were found using traditional null hypothesis significance tests; the groups were found to be equivalent using equivalence tests. Only when the analysis was repeated in treatment completers did CBT clients achieve around one‐quarter higher recovery rates. Both CBT and RTs appeared to be equally effective and showed recovery and completion rates equivalent to or above the national average. These findings demonstrate the advantages of therapies other than CBT. Future research is needed to replicate the equivalence between these two treatments and to explore specific patient characteristics that make one treatment more suitable and acceptable than the other.
Gender disclosure: The impact of peer behaviour and the firm's equality policies
Authors: García‐Sánchez Isabel‐María , Minutiello Valentina , Tettamanzi Patrizia 
Published: September 2021

AbstractGender equality is the future towards which society and companies have to move, and it is thus essential to know what efforts organisations are making. In this paper, we analyse the transparency of multinationals in matters of gender, in accordance with the requirements determined by the global reporting initiative (GRI) and United Nations (UN). The results suggest that higher levels of gender equality support the decision to report all GRI+UN indicators, a decision that has been maintained over time and is not moderated by peer disclosure. This behaviour facilitates the inclusion of companies in different reputation lists as a consequence of a greater commitment to gender equality, although these rankings also assess the completeness of the information when considering the disclosure of the GRI+UN indicators. The effect differs according to the practices of peer firms.
A variable gain reconfigurable mixer using gallium nitride high‐electron‐mobility transistor for wireless local area network applications
Authors: Vishnoi Manoj Kumar , Srikant Satya Sai , Mahapatra Rajendra Prasad , Sharma Shikha Swaroop 
Published: September 2021

SummaryIn this paper, a design of reconfigurable frequency mixer is adapted with gallium nitride high‐electron‐mobility transistor (GaN HEMT) architecture under variable gain, different intermediate frequency (IF) bandwidth, and active/passive configuration for multidisciplinary applications supported by wireless local area network (WLAN) framework. The low band (LB) and high band (HB) are reconfigured by shunting the power between the switching and transconductance at the IF stage of the transistor. The transistor switching mode (active and passive) and logic levels are fixed at the input stage, and the input radio frequency (RF) signal is steering between the gate and drain terminals of transistors. The transistor gain is controlled by adjusting transconductance at the input RF stage and the current‐steering in transimpedance stage at the output. The simulation results show that the proposed circuit provides variable gain of 23/25 and 30/32 dB and noise figure of 14.5/12.5 at the LB and HB reconfigurable scenarios. Hence, it is suitable for transceiver optimistic functions with converge large bandwidth through shunting stages of reconfigurable frequency mixer and transconductance.
The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development
Authors: Roffers‐Agarwal Julaine , Lidberg Kevin A. , Gammill Laura S. 
Published: September 2021

SummarySETD2 is a histone H3 lysine 36 (H3K36) tri‐methylase that is upregulated in response to neural crest induction. Because the H3K36 di‐methylase NSD3 and cytoplasmic non‐histone protein methylation are necessary for neural crest development, we investigated the expression and requirement for SETD2 in the neural crest. SetD2 is expressed throughout the chick blastoderm beginning at gastrulation. Subsequently, SetD2 mRNA becomes restricted to the neural plate, where it is strongly and dynamically expressed as neural tissue is regionalized and cell fate decisions are made. This includes expression in premigratory neural crest cells, which is downregulated prior to migration. Likely due to the early onset of its expression, SETD2 morpholino knockdown does not significantly alter premigratory Sox10 expression or neural crest migration; however, both are disrupted by a methyltransferase mutant SETD2 construct. These results suggest that SETD2 activity is essential for early neural crest development, further demonstrating that lysine methylation is an important mechanism regulating the neural crest.
Prevention of eating disorders—Efficacy and cost‐benefit of a school‐based program (“MaiStep”) in a randomized controlled trial (RCT)
Authors: Wolter Vanessa , Hammerle Florian , Buerger Arne , Ernst Verena 
Published: September 2021

AbstractObjectiveGiven the severity of eating disorders, effective and easily implementable prevention programs which reduce incidence rates and in addition have health‐economic benefits are essential. The majority of research on prevention programs focuses on questionnaire‐based efficacy or the reduction of eating disorder symptoms while neglecting the health‐economic perspective. By contrast, the present study focuses on both an efficacy analysis considering diagnostic criteria (DSM‐5) and on evaluating the cost‐benefit of a universal prevention program for eating disorders (“MaiStep”).MethodA three‐arm randomized controlled trial with baseline, posttreatment and 12‐month follow‐up was conducted with 1,654 adolescents (M = 13.35, SD = 0.76), comprising two intervention groups (MaiStep delivered by psychologists or teachers, IG‐T) and an active control group (ACG). The primary outcome was DSM‐5 eating disorder diagnosis measured with the SIAB‐S. Furthermore, the costs of the prevention program and the savings in health care costs were calculated.ResultsA significant difference in eating disorder diagnosis was found between the IG‐T and the ACG for posttreatment (χ2(1= 7.352, p = .007), Relative Risk (RR) = .53 and 12‐month follow‐up (χ2 (1= 5.203, p = .023), RR = .61. MaiStep proved to be cost‐effective (tcbr = 6.75), saving about 560,000 € (standardized per 1,000 students = 601,388.19 €).DiscussionUniversal prevention can both reduce incidence rates of eating disorders and be cost‐beneficial for health care systems. Future research should analyze prevention programs regarding efficacy and cost‐benefit to enable comparability and derive guidelines for political decision‐makers.Trial registration numberMaiStep is registered at the German Clinical Trials Register (DRKS00005050).
Metabolite mass spectrometry profiling of cacao genotypes reveals contrasting resistances to Ceratocystis cacaofunesta phytopathogen
Authors: Neves dos Santos Fábio , Magalhães Dilze Maria Argôlo , Luz Edna Dora Martins Newman , Eberlin Marcos Nogueira , Simionato Ana Valéria Colnaghi 
Published: September 2021

AbstractCeratocystis wilt is a lethal disease of cacao, and the search for resistant genotypes may provide the best way to deal with the disease. Resistance or susceptibility behavior of some cacao genotypes when infected by Ceratocystis cacaofunesta is not yet understood. Herein, we report an LC‐MS metabolomic screening analysis based on high‐resolution MS to obtain comprehensive metabolic profile associated with multivariate data analysis of PLS‐DA, which was effective to classify CCN‐51 and TSH‐1188 as resistant genotypes to C. cacaofunesta fungus, while CEPEC2002 was classified as a susceptible one. Using reversed‐phase LC method, electrospray interface, and high‐resolution tandem MS by the quadrupole‐TOF analyzer, the typical profiles of metabolites, such as phenylpropanoids, flavonoids, lipids, alkaloids, and amino acids, were obtained. Untargeted metabolite profiles were used to construct discriminant analysis by partial least squares (PLS‐DA)‐derived loading plots, which placed the cacao genotypes into two major clusters related to susceptible or resistant groups. Linolenic, linoleic, oleic, stearic, arachidonic, and asiatic acids were annotated metabolites of infected, susceptible, and resistant genotypes, while methyl jasmonate, jasmonic acid, hydroxylated jasmonic acid, caffeine, and theobromine were annotated as constituents of the resistant genotypes. Trends of these typical metabolites levels revealed that CCN51 is susceptible, CEPEC2002 is moderately susceptible, and TSH1188 is resistant to C. cacaofunesta. Therefore, profiles of major metabolites as screened by LC‐MS offer an efficient tool to reveal the level of resistance of cacao genotypes to C. cacaofunesta present in any farm around the world.