bluuebunny/crossref_metadata_2025_split huggingface dataset:
It’s time to eliminate the mismatch between pediatric training and practice
Authors: Oberklaid Frank 
Published: December 2021

AbstractThe quality of pediatric clinical practice is dependent on the training received during residency. It is assumed that the content of the training will adequately prepare pediatricians for the sorts of problems and issues they will be asked to manage in community settings. While over the past several decades there have been major changes in pediatric morbidity, there is evidence that training and service delivery models have not evolved; there is a significant mismatch between training and evidence-based clinical practice. A recent paper published in this journal (1) drew attention to the inadequacy of pediatricians’ training in child development. The reality of major gaps in the content and experiences of pediatric training in Israel are widely held, and there have been repeated calls for an increased focus on community child health and developmental and behavioural pediatrics. While it appears that finally there are some small initial steps to this end, it is strongly recommended that there be a long overdue, radical rethink of pediatric training programs.
Methodological quality and reporting standards in systematic reviews with meta-analysis of physical activity studies: a report from the Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative)
Authors: Oliveira Nórton Luís , Botton Cíntia Ehlers , De Nardi Angélica Trevisan , Umpierre Daniel 
Published: December 2021

Abstract
Background
Several resources have been developed (e.g., reporting guidelines) to promote high-standard practices in health research. However, there was no continuous and systematic assessment of recommended practices in published systematic reviews with meta-analysis (SRMAs), which increases the usability of the available resources. Therefore, we aimed to assess the methodological and reporting standards in SRMAs of physical activity studies. This report presents the main results of the SEES Initiative in 2019.

Methods
Our approach is based on a prospective systematic review methodology to implement post-publication surveillance of research practices in exercise sciences. Briefly, during the year 2019, pre-specified searches were conducted monthly (PubMed/MEDLINE) in journals from the exercise sciences (n = 9) and medicine (n = 5). The assessments were independently conducted by two authors, based on 36 items/practices derived from established statements/tools (PRISMA, AMSTAR 2, ROBIS). To be eligible, SRMAs should summarize studies that had, at least, one arm consisting of physical activity interventions/exposures and one health or behavioral outcome.

Results
Out of 1028 studies assessed for eligibility, 103 SRMAs were included. The minimum adherence was 13/36 items, whereas only one SRMA adhered to all items. Some highly contemplated items included identification of title as SRMA (97.1%) and descriptions of the main outcome in the abstract (95.1%) and risk of bias (RoB) assessment (95.1%). Some poorly contemplated items included publicly available protocol (4.9%), discussion of the results in light of RoB in studies included (32.0%), and data sharing statements (35.9%).

Conclusion
In summary, there is a suboptimal adherence to recommended practices on methodological quality and reporting standards in the SRMAs of physical activity intervention/exposure evaluated from the selected journals in 2019, which likely reduce the reproducibility and usefulness of these studies. This incipient evidence from our first 12 months of post-publication surveillance should serve as a call for attention and action for multiple stakeholders (e.g., authors, reviewers, editors, funders, academic institutions) in this important health research field.
High perturbations of a new Kirchhoff problem involving the p-Laplace operator
Authors: Zhang Zhongyi , Song Yueqiang 
Published: December 2021

AbstractIn the present work we are concerned with the existence and multiplicity of solutions for the following new Kirchhoff problem involving the p-Laplace operator: $$ \textstyle\begin{cases} - (a-b\int _{\Omega } \vert \nabla u \vert ^{p}\,dx ) \Delta _{p}u = \lambda \vert u \vert ^{q-2}u + g(x, u), & x \in \Omega , \\ u = 0, & x \in \partial \Omega , \end{cases} $$

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Patient, medical and legal perspectives on reentry: the need for a low-barrier, collaborative, patient-centered approach
Authors: Pulitzer Zoe , Box Maria , Hansen Laura , Tiruneh Yordanos M. , Nijhawan Ank E. 
Published: December 2021

AbstractBackgroundWorldwide, the United States has the highest incarceration rate per capita. Thousands of people are released from US correctional facilities each year, including many who are impacted by HIV infection and substance use disorder (SUD), two frequently comorbid conditions that present multiple challenges upon reentry. Reentry and care engagement research involving justice-involved people with HIV (PWH) with comorbid SUD has been largely limited to the perspective of those released. To formulate effective interventions for this population aimed at maintaining health and reducing recidivism, it is crucial to collect data from formerly incarcerated individuals with firsthand experience of the reentry process as well as other actors within the reentry framework. Insights from medical and legal service providers working in reentry systems have the potential to address key implementation concerns. To inform an intervention aimed at helping recently-released individuals PWH and SUD, we conducted a qualitative study to assess barriers and facilitators to community reentry from the perspectives of diverse consumers and providers of medical, legal, and reentry services.ResultsFifteen stakeholders within Dallas County participated in in-person interviews. Results indicated that 1) Patients/clients emphasized psychosocial support and individual attitude more than medical and legal participants, who chiefly focused on logistical factors such as finances, housing, and transportation; 2) Patients/clients expressed both medical and legal needs during the reentry period, though medical providers and participants from legal entities mainly expressed concerns limited to their respective scopes of work; 3) All three participant groups underscored the need for a low-barrier, collaborative, patient-centered approach to reentry with the goal of achieving self-sufficiency.ConclusionsFindings support and extend existing literature detailing the barriers and facilitators to successful reentry. Our findings underscore the notion that an effective reentry intervention addresses both medical and legal needs, includes an individualized approach that incorporates psychosocial needs, and focuses on establishing self-sufficiency.
Investigation of soil nutrients and associated rhizobacterial communities in different sugarcane genotypes in relation to sugar content
Authors: Khan Abdullah , Wang Ziting , Chen Zhengxia , Bu Junyao , Adnan Muhammad , Zhang Muqing 
Published: December 2021

Abstract
Background
Plant microbiomes and soil are bridged by rhizobacteria, maintaining and improving plant health and growth in different aspects. This study was conducted in the field station of the Guangxi University, Fusui, China. We investigated soil nutrients, root morphology and rhizosphere bacterial composition, and community structures in 18 sugarcane genotypes concerning sugar content under the same environmental condition.

Results
Most of the rhizosphere microbiomes of these genotypes exhibited similar bacterial compositions. However, the evaluated genotypes harbored a significant effect and difference in the abundance of operational taxonomic units and bacterial composition in the rhizosphere compartments. Alpha diversity analysis on the rhizosphere microbiome showed a significant difference in the bacterial diversity (Shannon index, p < 0.001) and OTU richness (Chao1, p < 0.001). The principal coordinate analysis (PCoA) and hierarchical cluster analysis revealed that the genotype replicated samples grouped, indicating their similarity. Besides, these genotypes also differed significantly in terms of root structure and soil properties. A significant genotypic effect (p < 0.05) was found in the root traits except for rooting depth. The soil chemical properties were significantly different among the evaluated genotypes. Furthermore, sucrose content was strongly correlated with the total root length (TRL) and rooting depth. Genotypes (FN-1702, GUC-3, ZZ-13, ZZ-10, ZZ-6) were the best performing and distinct in bacterial diversity, root structure, soil parameters and sucrose content.

Conclusion
The results showed a closely related and highly conserved bacterial community of the rhizosphere microbiome. The rhizosphere microbiome diversity and related bacterial communities were highly associated with the relevant plant taxa, probably at the order level. As a result, it is possible to conclude that the host genotype and the same environmental condition influenced the rhizosphere microbiome via root phenes. Future research regarding plant phenes and microbiome functional groups could be considered an essential factor.

Graphic abstract
Which role models are effective for which students? A systematic review and four recommendations for maximizing the effectiveness of role models in STEM
Authors: Gladstone Jessica R. , Cimpian Andrei 
Published: December 2021

AbstractIs exposing students to role models an effective tool for diversifying science, technology, engineering, and mathematics (STEM)? So far, the evidence for this claim is mixed. Here, we set out to identify systematic sources of variability in STEM role models’ effects on student motivation: If we determinewhich role modelsare effective forwhich students, we will be in a better position to maximize role models’ impact as a tool for diversifying STEM. A systematic narrative review of the literature (55 articles) investigated the effects of role models on students’ STEM motivation as a function of several key features of the role models (their perceived competence, their perceived similarity to students, and the perceived attainability of their success) and the students (their gender, race/ethnicity, age, and identification with STEM). We conclude with four concrete recommendations for ensuring that STEM role models are motivating for students of all backgrounds and demographics—an important step toward diversifying STEM.
Consensus-based multidimensional due diligence of fintech-enhanced green energy investment projects
Authors: Liu Wei , Sun Youfa , Yüksel Serhat , Dinçer Hasan 
Published: December 2021

AbstractThe purpose of this study is to provide a hybrid group decision-making approach to evaluate fintech-based financial alternatives for green energy investment projects. First, the multidimensional factors of due diligence for fintech-based financing alternatives of green energy investment projects are identified. In this regard, the balanced scorecard perspectives are considered. Next, consensus-based group decision-making analysis is performed. Second, impact-relation directions for fintech-based financing alternatives of green energy investment projects are defined. For this purpose, the spherical fuzzy Decision-Making Trial and Evaluation Laboratory (DEMATEL) methodology is applied. The novelty of this study is its proposal of a new outlook to due diligence of fintech-project financing for renewable energy investments by using the group and integrated decision-making approaches with spherical fuzzy DEMATEL. The findings indicate that customer expectations are the most essential factor for the revenue sharing and rewarding models. Additionally, this study identified that organizational competency plays the most important role with respect to the peer-to-business debt model. In contrast, the conclusion was reached that financial returns have the greatest importance for the equity sharing model.
The cultural dimension of environment: Ethnoscientific study on Santhal community in eastern India
Authors: Majumdar Koustab , Chatterjee Dipankar 
Published: December 2021

AbstractThis study explores the Santhal community to enhance the understanding of the human-nature relationship that fully captures distinct intricacies of ethnoecology. Relying on a qualitative research design, this study focuses on the perception and interpretation of environmental aspects using ethnoscientific methods among Santhals in West Bengal, India. It reveals that Santhals are still unique in perceiving the environment learned through folk models. Santhal’s perception of environmental domains is constituted by various cognitive elements (resource distributions, care, feelings, attachment, myths, and superstitious credence toward their environment) and multifaceted interpretations (living beings, nonliving objects, natural and built environment). Based on its evidence, this study recommends that indigenous worldview-based ethnoscientific knowledge is the identity of indigenity that shapes ethnoscientific knowledge can be used in sustainable resource management practice. Furthermore, the study proposes a view that ignoring this unique ethnoscientific knowledge-based worldview base may degenerate the indigenous culture.
LSGAN-AT: enhancing malware detector robustness against adversarial examples
Authors: Wang Jianhua , Chang Xiaolin , Wang Yixiang , Rodríguez Ricardo J. , Zhang Jianan 
Published: December 2021

AbstractAdversarial Malware Example (AME)-based adversarial training can effectively enhance the robustness of Machine Learning (ML)-based malware detectors against AME. AME quality is a key factor to the robustness enhancement. Generative Adversarial Network (GAN) is a kind of AME generation method, but the existing GAN-based AME generation methods have the issues of inadequate optimization, mode collapse and training instability. In this paper, we propose a novel approach (denote as LSGAN-AT) to enhance ML-based malware detector robustness against Adversarial Examples, which includes LSGAN module and AT module. LSGAN module can generate more effective and smoother AME by utilizing brand-new network structures and Least Square (LS) loss to optimize boundary samples. AT module makes adversarial training using AME generated by LSGAN to generate ML-based Robust Malware Detector (RMD). Extensive experiment results validate the better transferability of AME in terms of attacking 6 ML detectors and the RMD transferability in terms of resisting the MalGAN black-box attack. The results also verify the performance of the generated RMD in the recognition rate of AME.
CD123 Expression Is Associated With High-Risk Disease Characteristics in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group
Authors: Lamble Adam J. , Eidenschink Brodersen Lisa , Alonzo Todd A. , Wang Jim , Pardo Laura , Sung Lillian , Cooper Todd M. , Kolb E. Anders , Aplenc Richard , Tasian Sarah K. , Loken Michael R. , Meshinchi Soheil 
Published: December 2021

PURPOSE Increased CD123 surface expression has been associated with high-risk disease characteristics in adult acute myeloid leukemia (AML), but has not been well-characterized in childhood AML. In this study, we defined CD123 expression and associated clinical characteristics in a uniformly treated cohort of pediatric patients with newly diagnosed AML enrolled on the Children's Oncology Group AAML1031 phase III trial ( NCT01371981 ). MATERIALS AND METHODS AML blasts within diagnostic bone marrow specimens (n = 1,040) were prospectively analyzed for CD123 protein expression by multidimensional flow cytometry immunophenotyping at a central clinical laboratory. Patients were stratified as low-risk or high-risk on the basis of (1) leukemia-associated cytogenetic and molecular alterations and (2) end-of-induction measurable residual disease levels. RESULTS The study population was divided into CD123 expression–based quartiles (n = 260 each) for analysis. Those with highest CD123 expression (quartile 4 [Q4]) had higher prevalence of high-risk KMT2A rearrangements and FLT3-ITD mutations ( P < .001 for both) and lower prevalence of low-risk t(8;21), inv(16), and CEBPA mutations ( P < .001 for all). Patients in lower CD123 expression quartiles (Q1-3) had similar relapse risk, event-free survival, and overall survival. Conversely, Q4 patients had a significantly higher relapse risk (53% v 39%, P < .001), lower event-free survival (49% v 69%, P < .001), and lower overall survival (32% v 50%, P < .001) in comparison with Q1-3 patients. CD123 maintained independent significance for outcomes when all known contemporary high-risk cytogenetic and molecular markers were incorporated into multivariable Cox regression analysis. CONCLUSION CD123 is strongly associated with disease-relevant cytogenetic and molecular alterations in childhood AML. CD123 is a critical biomarker and promising immunotherapeutic target for children with relapsed or refractory AML, given its prevalent expression and enrichment in patients with high-risk genetic alterations and inferior clinical outcomes with conventional therapy.
Hydroxyethyl Starch for Fluid Management in Patients Undergoing Major Abdominal Surgery: A Systematic Review With Meta-analysis and Trial Sequential Analysis
Authors: Pensier Joris , Deffontis Lucas , Rollé Amélie , Aarab Yassir , Capdevila Mathieu , Monet Clément , Carr Julie , Futier Emmanuel , Molinari Nicolas , Jaber Samir , De Jong Audrey 
Published: December 2021

BACKGROUND:
In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch (HES) solutions have been raised. However, HES solutions may yet have a role to play in major abdominal surgery. This meta-analysis and trial sequential analysis (TSA) aimed to investigate the effect of HES intravascular volume replacement on the risk of AKI, intraoperative blood transfusion, and postoperative intra-abdominal complications compared to crystalloid intravascular volume replacement.

METHODS:
In this meta-analysis and TSA, we searched for randomized controlled trials (RCTs) comparing intraoperative HES intravascular volume replacement to crystalloid intravascular volume replacement in adult patients undergoing major abdominal surgery. Primary outcome was 30-day AKI, defined as a binary outcome according to Kidney Disease Improving Global Outcomes (KDIGO) criteria, combining stages 1, 2, and 3 into an AKI category versus no AKI category (stage 0). Secondary outcomes included rates of intraoperative blood transfusion and postoperative intra-abdominal complications. We used random effects models to calculate summary estimates. We used relative risk (RR) as summary measure for dichotomous outcomes, with corresponding 95% confidence intervals (CIs) for the primary outcome (P value <.05 was considered statistically significant) and 99% CI after Bonferroni correction for the secondary outcomes (P value <.01 was considered statistically significant).

RESULTS:
Seven RCTs including 2398 patients were included. HES intravascular volume replacement was not associated with an increased risk of 30-day AKI (RR = 1.22, 95% CI, 0.94–1.59; P = .13), when compared to crystalloid intravascular volume replacement. According to TSA, this analysis was underpowered. HES intravascular volume replacement was associated with higher rates of blood transfusion (RR = 1.57 99% CI, 1.10–2.25; P = .001), and similar rates of postoperative intra-abdominal complications (RR = 0.76 99% CI, 0.57–1.02; P = .02).

CONCLUSIONS:
In this meta-analysis to focus on HES intravascular volume replacement in major abdominal surgery, HES intravascular volume replacement was not associated with a higher risk of 30-day AKI when compared to crystalloid intravascular volume replacement. However, CI and TSA do not exclude harmful effects of HES intravascular volume replacement on the renal function.
Case Report of Angular Post-Tuberculotic Kyphosis Corrected Through Pedicle Subtraction Osteotomy Above C7
Authors: Ma Shengbiao , Yu Honggui , Zhou Zhenhai , Wu Chunyang , Liu Zhiming , Deng Wenqiang , Cao Kai 
Published: December 2021

BACKGROUND AND IMPORTANCE:
Angular cervical kyphosis and its association with syringomyelia were rarely described. Correcting this kind of deformity from the front is extremely difficult or even impossible. Meanwhile, no study has made a report about correcting angular cervical kyphosis through pedicle subtraction osteotomy (PSO) above C7 because of the special anatomy of the vertebral artery. This is the first case of cervical deformity correction through PSO above C7.

CLINICAL PRESENTATION:
We present the case of a 52-yr-old man who previously underwent debridement, decompression, and skull traction for cervical tuberculosis at age 6 yr. The sequelae of right-hand weakness occurred after surgery, and cervical kyphosis formed gradually. The patient recently started to complain of a severe neck pain. X-rays showed a cervical sagittal malalignment due to the angular kyphosis. Computed tomography scans revealed a fused angular kyphosis at C6-7, and MRI showed a long syringomyelia distal to the kyphosis. The definite diagnosis of the patient was post-tuberculotic cervical angular kyphosis, and because of the extremely narrow surgery corridor from the front, we decided to perform the surgery in a posterior approach. Hence, the patient was treated with the PSO with a long-segment pedicle screw fixation from C3 to T5 and received satisfactory angular kyphosis correction.

CONCLUSION:
PSO above C7 to correct angular cervical kyphosis is feasible and reasonable when there is no other better solution, and it can achieve a satisfactory kyphotic deformity correction.
Septin-microtubule association via a motif unique to isoform 1 of septin 9 tunes stress fibers
Authors: Kuzmić Mira , Castro Linares Gerard , Leischner Fialová Jindřiška , Iv François , Salaün Danièle , Llewellyn Alex , Gomes Maxime , Belhabib Mayssa , Liu Yuxiang , Asano Keisuke , Rodrigues Magda , Isnardon Daniel , Tachibana Taro , Koenderink Gijsje H. , Badache Ali , Mavrakis Manos , Verdier-Pinard Pascal 
Published: December 2021

ABSTRACT
Septins, a family of GTP-binding proteins that assemble into higher order structures, interface with the membrane, actin filaments and microtubules, and are thus important regulators of cytoarchitecture. Septin 9 (SEPT9), which is frequently overexpressed in tumors and mutated in hereditary neuralgic amyotrophy (HNA), mediates the binding of septins to microtubules, but the molecular determinants of this interaction remained uncertain. We demonstrate that a short microtubule-associated protein (MAP)-like motif unique to SEPT9 isoform 1 (SEPT9_i1) drives septin octamer-microtubule interaction in cells and in vitro reconstitutions. Septin-microtubule association requires polymerizable septin octamers harboring SEPT9_i1. Although outside of the MAP-like motif, HNA mutations abrogate this association, identifying a putative regulatory domain. Removal of this domain from SEPT9_i1 sequesters septins on microtubules, promotes microtubule stability and alters actomyosin fiber distribution and tension. Thus, we identify key molecular determinants and potential regulatory roles of septin-microtubule interaction, paving the way to deciphering the mechanisms underlying septin-associated pathologies.
This article has an associated First Person interview with the first author of the paper.