bluuebunny/crossref_metadata_2025_split huggingface dataset:
The student mental health crisis: Assessing psychiatric and developmental explanatory models
Authors: Andersen Robert , Holm Anders , Côté James E. 
Published: January 2021

ABSTRACTIntroductionStudent mental health problems are now commonly understood using a psychiatric model in which diagnosed anxiety and mood disorders are viewed to be so widespread as to constitute a crisis. Less attention is given to the role of developmental processes, such as identity formation and purpose, in understanding the types of distress current university students can experience. We fill this void by simultaneously assessing the effectiveness of both psychiatric and developmental variables in predicting how often students feel emotional distress in the form of frequently feeling too anxious, depressed, or overwhelmed to study.MethodsBinary logit models were fitted to online survey data collected from a cross‐sectional, nation‐wide sample of 1010 Canadian full‐time university students aged 18 to 24 (63% female).ResultsOur findings confirm that the psychiatric and developmental models both explain variance in academic distress. We also found that a developmental model operationalized using key measures of identity formation and purpose significantly accounted for academic distress, over and above variance explained by psychiatric diagnoses. In other words, not only do many students with a psychiatric diagnosis experience distress linked to problems with identity/purpose that interferes with studying, but so do a considerable proportion of students without any diagnosis. This impact persists after controlling for a host of variables assessing demographic/family background, academic preparation and performance, and a number of factors believed to aggravate emotional distress.ConclusionsUniversities can respond to the mental health crisis by approaching some forms of distress as developmental problems associated with identity and purpose.
Randomized controlled trials evaluating adolescent dating violence prevention programs with an outcome of reduced perpetration and/or victimization: A meta‐analysis
Authors: Russell Katie N. , Voith Laura A. , Lee Hyunjune 
Published: January 2021

ABSTRACTIntroductionAdolescent dating violence (ADV), including psychological, physical, threatening, and/or sexual abuse between adolescent romantic partners, is an epidemic in the United States, with youth report rates ranging from 15 to 77% for perpetration and 14–73% for victimization. ADV victimization is associated with multiple adverse outcomes in both adolescence and adulthood (e.g., suicidal ideation, substance use, bullying), as is ADV perpetration (e.g., sexually transmitted infections, intimate partner violence in adulthood). Given the high prevalence and profound impact of ADV on youth in the US, many prevention efforts have emerged in the past 20 years. Previous reviews of these efforts have focused primarily on school‐based interventions or have broadly reviewed programs including all research design types and outcomes. This review is the first to provide a comprehensive, quantitative synthesis of all existing ADV prevention programs tested using randomized controlled trial designs with a control group, specifically measuring ADV perpetration and/or victimization as outcomes.MethodsEmploying a systematic literature search and screening protocol, nine studies were identified for meta‐analysis.ResultsResults indicate that ADV prevention programs may decrease the risk of emotional, physical, and sexual perpetration, as well as emotional and physical victimization.ConclusionsThis is the first review to uncover significant intervention effects on the actual occurrence of ADV, with previous reviews only finding effects on outcomes such as ADV knowledge and attitude. Findings suggest that ADV prevention programs are promising and may warrant implementation more broadly with youth, and this review provides methodological suggestions for future research evaluating new ADV prevention programs.
Brief report: Identified barriers and proposed solutions for recruiting young Black sexual minority men in HIV‐related research
Authors: Parchem Benjamin , Molock Sherry Davis 
Published: January 2021

ABSTRACTIntroductionYoung Black sexual minority men represent a high priority population for HIV prevention research yet the existing literature is not proportional to the current health disparity observed. The challenge of engaging this intersectional population in research on a stigmatized topic likely contributes to the dearth of literature.MethodsThis brief report examines the current recruitment strategies for engaging sexual minority men in HIV‐related research and identifies individual and system‐level barriers that contribute to the underrepresentation of Black sexual minority men in HIV‐related research. Qualitative data is integrated from Project HATCH (Helping African American Teens Combat HIV), an ongoing recruitment effort of 14‐21‐year‐old Black sexual minority men in Washington D.C., United States.ResultsIdentified barriers to recruiting young Black sexual minority men include cultural stigma, mistrust of research institutions, the ‘coming out’ process for queer youth, assent procedures for youth, and others.ConclusionsWe propose several solutions for recruitment including geospatial technology, social media, and community spaces of trust (i.e., churches and schools). Additional larger scale solutions include destigmatizing youths’ sexuality and prioritizing the advancement of Black scholars in academia and research endeavors.
REASON-GIVING AND THE DUTY TO OBEY: PERSPECTIVES FROM CLASSICAL ISLAMIC JURISPRUDENCE
Authors: Farahat Omar 
Published: January 2021

AbstractThe duty to obey juristic injunctions in Islamic law is often assumed to follow a simple model: God commands, the jurists discover the meaning of those commands, and the faithful follow the jurists’ interpretation. By examining the arguments advanced by some prominent classical Islamic jurisprudes in support of the claims for law's normativity, I show that the jurists saw themselves as representatives of their communities in the quest to formulate opinions about actions in a way that is faithful to revelation. This model can be summarized as follows: (1) the jurists, by virtue of their knowledge, inform individuals of how to act according to revelation; (2) the pronouncement of a jurist who is knowledgeable and fair may be followed without revisiting their justifications; (3) everyone has a duty to act according to revelation and to rebuke those who do not. A reasonable individual should be motivated to follow juristic pronouncements when all these conditions are present. My main claim is that the basic model wherein God is an authoritative commander and the jurists are informants is unsatisfactory. The jurists saw themselves as more than mere discoverers and informers. This Islamic model has unique features when it comes to understanding authority in general. The uniform commitment to a formal moral source, coupled with the contingent nature of the robust reasons given by the system, make the Islamic model distinct from some modern accounts. The Islamic model offers a view of legal authority that is specific to a cohesive community that shares a basic moral commitment. This model fits the classical need for a theory of authority that is both persuasive and authoritative.
U–Pb geochronology and trace-element composition of zircons from the Jinchang Au–Ni deposit, SW China, and their implications for tectonics
Authors: Xu Lingang , Kong Zhigang , Qu Jianfei , Qiu Zhiyin , Gao Jianfeng 
Published: January 2021

AbstractSituated between the South China Block and the Simao Block, the Ailaoshan Belt is a significant component of the Jinshajiang–Ailaoshan tectonic-magmatic-metallogenic belt of southwestern China. The formation of the Ailaoshan Belt is closely related to the evolution of the Palaeo-Tethys Ocean. In this study, we constrain ages of sedimentation in the Jinchang Au–Ni deposit in the Ailaoshan Belt, using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) U–Pb ages of the youngest populations of detrital zircons separated from a chert layer and two uncomfortably overlying meta-sandstones. The combined data of the meta-sandstone samples from the Yiwanshui Formation yielded a concordant age of 250.8 ± 0.6 Ma (mean square weighted deviation (MSWD), 2.8; n = 26). The chert sample from the Jinchangyan Formation yielded a concordant age of 347.0 ± 1.5 Ma (MSWD, 2.8; n = 16). Detrital zircons from the meta-sandstone are characterized by low rare earth element contents (∑REE) and low Y, and high U and U/Yb ratio, suggesting a continental crustal origin. Zircons in the meta-sandstones were derived mainly from pre-collision subduction zone magmatic rocks related to the closure of the Palaeo-Tethys Ocean. In contrast, detrital zircons from the chert contain relatively high ∑REE and Y, and low U and U/Yb ratio, suggesting an oceanic crust origin. Zircons in the chert bed were derived mainly from ophiolites related to seafloor spreading in a branch of the Palaeo-Tethys Ocean.
Transcatheter pulmonary valve implantation in tetralogy of Fallot and Ebstein’s anomaly with one and a half ventricular repair
Authors: Guzeltas Alper , Ugan Atik Sezen , Tanidir Ibrahim Cansaran 
Published: January 2021

AbstractThe coexistence of tetralogy of Fallot and Ebstein’s anomaly is extremely rare. There are only a few case reports in the literature, and surgical options for the treatment are controversial. There is insufficient data on long-term follow-up of patients and management of complications. In this case report, we present a 20-year-old adult with operated tetralogy of Fallot, Ebstein’s anomaly, and Glenn anastomosis who underwent transcatheter pulmonary valve implantation for severe pulmonary insufficiency.
Aortopulmonary window with anomalous origin of the right coronary artery from the pulmonary trunk
Authors: Atalay Atakan , Soran Turkcan Başak , Kulahcioglu Emre , Eris Deniz , Ece İbrahim , Aydın Hakan 
Published: January 2021

AbstractAnomalous origin of coronary artery originating from the pulmonary artery in conjunction with the aorticopulmonary window (APW) is a rare but a significant anomaly in the era of congenital cardiac diseases. The occurrence of anomalous origin of the right coronary artery from the pulmonary artery among the associated anomalies is less than 5%. The severity of the clinical condition of these patients depends on the degree of left–right shunt and compromise of the pulmonary blood flow. We report surgical management of a case of a 45-day-old infant with APW, ventricular septal defect, and anomalous origin of coronary artery originated from the pulmonary artery.
A Brief Period of Wakeful Rest after Learning Enhances Verbal Memory in Stroke Survivors
Authors: Evans Felicity A. , Stolwyk Renerus J. , Wong Dana 
Published: January 2021

AbstractObjective:Accumulating evidence suggests that wakeful rest (a period of minimal cognitive stimulation) enhances memory in clinical populations with memory impairment. However, no study has previously examined the efficacy of this technique in stroke survivors, despite the high prevalence of post-stroke memory difficulties. We aimed to investigate whether wakeful rest enhances verbal memory in stroke survivors and healthy controls.Method:Twenty-four stroke survivors and 24 healthy controls were presented with two short stories; one story was followed by a 10-minute period of wakeful rest and the other was followed by a 10-minute visual interference task. A mixed factorial analysis of variance (ANOVA) with pairwise comparisons was used to compare participants’ story retention at two time points.Results:After 15–30 minutes, stroke survivors (p = .002, d = .73), and healthy controls (p = .001, d = .76) retained more information from the story followed by wakeful rest, compared with the story followed by an interference task. While wakeful rest remained the superior condition in healthy controls after 7 days (p = .01, d = .58), the beneficial effect was not maintained in stroke survivors (p = .35, d = .19).Conclusions:Wakeful rest is a promising technique, which significantly enhanced verbal memory after 15–30 minutes in both groups; however, no significant benefit of wakeful rest was observed after 7 days in stroke survivors. Preliminary findings suggest that wakeful rest enhances early memory consolidation processes by protecting against the effects of interference after learning in stroke survivors.
An exploration of key barriers to healthcare providers’ use of food prescription (FRx) interventions in the rural South
Authors: Coward Kara Beth , Cafer Anne , Rosenthal Meagen , Allen David , Paltanwale Queenie 
Published: January 2021

AbstractObjective:The purpose of this exploratory study was to examine the attitude towards food prescriptions (FRx) interventions among clinicians and identify potential barriers to their use in clinical practice.Design:The current study employed an exploratory research design using in-depth semi-structured interviews. Research participants were selected from primary care facilities, family practice offices and obesity clinics located in Mississippi and Louisiana.Setting:Providers selected for participation in the current study serve predominantly rural, low-income communities in the US South.Participants:From an original population of fifty healthcare providers that included physicians, registered dieticians and nurse practitioners, from Oxford, Tupelo, Batesville, Jackson, and Charleston, MS and New Orleans, LA. Fifteen healthcare providers agreed to participate, including three physicians, four registered dieticians, three nurses and three nurse practitioners.Results:The current study found that while healthcare providers expressed a desire to use FRx interventions, there was a universal lack of understanding by healthcare providers of what FRx interventions were, how they were implemented and what outcomes they were likely to influence.Conclusions:The current study identified key bottlenecks in the use of FRx interventions at the clinic level and data provided evidence for two key recommendations: (1) development and validation of a screening tool to be used by clinicians for enrolling patients in such interventions and (2) implementation of nutrition education in primary professional training, as well as in continuing education.
Legitimacy and public opinion: a five-step model
Authors: Noyon Lucas , de Keijser Jan W. , Crijns Jan H. 
Published: January 2021

AbstractTo date, in Western jurisdictions, many criminal justice reforms are devised and implemented with a close eye on public opinion. These are typically intended to regain or foster legitimacy. However, within this context, there is no common understanding of this concept. This essay aims to provide such a conceptualisation of legitimacy, to enable a consistent and systematic evaluation of attempts to accommodate public opinion. To this end, five levels of legitimacy research are discussed that could structure evaluations of public-opinion-targeted reforms: (1) the normative dimension, (2) the ‘audiences’ addressed, (3) the purpose of the reforms, (4) trust and distrust, and (5) dialogic, or longitudinal effects. Furthermore, since research departing from these five levels of analysis is likely to result in observations that are, by nature, incommensurable, it is argued that an overall assessment of legitimacy always requires ajudgment, rather than mere measurement.
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis
Authors: Huang Yao-Hui , Cai Kun , Xu Peng-Peng , Wang Li , Huang Chuan-Xin , Fang Ying , Cheng Shu , Sun Xiao-Jian , Liu Feng , Huang Jin-Yan , Ji Meng-Meng , Zhao Wei-Li 
Published: January 2021

AbstractEpigenetic alterations play an important role in tumor progression of diffuse large B-cell lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on tumor microenvironment remains to be determined. The core set of genes relating to histone methylation (KMT2D, KMT2C, EZH2), histone acetylation (CREBBP, EP300), DNA methylation (TET2), and chromatin remodeling (ARID1A) were detected in the training cohort of 316 patients by whole-genome/exome sequencing (WGS/WES) and in the validation cohort of 303 patients with newly diagnosed DLBCL by targeted sequencing. Their correlation with peripheral blood immune cells and clinical outcomes were assessed. Underlying mechanisms on tumor microenvironment were investigated both in vitro and in vivo. Among all 619 DLBCL patients, somatic mutations in KMT2D (19.5%) were most frequently observed, followed by mutations in ARID1A (8.7%), CREBBP (8.4%), KMT2C (8.2%), TET2 (7.8%), EP300 (6.8%), and EZH2 (2.9%). Among them, CREBBP/EP300 mutations were significantly associated with decreased peripheral blood absolute lymphocyte-to-monocyte ratios, as well as inferior progression-free and overall survival. In B-lymphoma cells, the mutation or knockdown of CREBBP or EP300 inhibited H3K27 acetylation, downregulated FBXW7 expression, activated the NOTCH pathway, and downstream CCL2/CSF1 expression, resulting in tumor-associated macrophage polarization to M2 phenotype and tumor cell proliferation. In B-lymphoma murine models, xenografted tumors bearing CREBBP/EP300 mutation presented lower H3K27 acetylation, higher M2 macrophage recruitment, and more rapid tumor growth than those with CREBBP/EP300 wild-type control via FBXW7-NOTCH-CCL2/CSF1 axis. Our work thus contributed to the understanding of aberrant histone acetylation regulation on tumor microenvironment as an alternative mechanism of tumor progression in DLBCL.
Pantothenate mediates the coordination of whitefly and symbiont fitness
Authors: Ren Fei-Rong , Sun Xiang , Wang Tian-Yu , Yan Jin-Yang , Yao Ya-Lin , Li Chu-Qiao , Luan Jun-Bo 
Published: January 2021

Abstract
Intracellular symbionts in insects often have reduced genomes. Host acquisition of genes from bacteria is an important adaptation that supports symbionts. However, the function of horizontally transferred genes in insect symbiosis remains largely unclear. The primary symbiont Portiera housed in bacteriocytes lacks pantothenate synthesis genes: panB and panC, which is presumably complemented by a fused gene panB-panC (hereafter panBC) horizontally transferred from bacteria in Bemisia tabaci MEAM1. We found panBC in many laboratory cultures, and species of B. tabaci shares a common evolutionary origin. We demonstrated that complementation with whitefly panBC rescued E. coli pantothenate gene knockout mutants. Portiera elimination decreased the pantothenate level and PanBC abundance in bacteriocytes, and reduced whitefly survival and fecundity. Silencing PanBC decreased the Portiera titer, reduced the pantothenate level, and decreased whitefly survival and fecundity. Supplementation with pantothenate restored the symbiont titer, PanBC level, and fitness of RNAi whiteflies. These data suggest that pantothenate synthesis requires cooperation and coordination of whitefly PanBC expression and Portiera. This host–symbiont co-regulation was mediated by the pantothenate level. Our findings demonstrated that pantothenate production, by the cooperation of a horizontally acquired, fused bacteria gene and Portiera, facilitates the coordination of whitefly and symbiont fitness. Thus, this study extends our understanding on the basis of complex host–symbiont interactions.
Reconfiguration of metabolic fluxes in Pseudomonas putida as a response to sub-lethal oxidative stress
Authors: Nikel Pablo I , Fuhrer Tobias , Chavarría Max , Sánchez-Pascuala Alberto , Sauer Uwe , de Lorenzo Víctor 
Published: January 2021

Abstract
As a frequent inhabitant of sites polluted with toxic chemicals, the soil bacterium and plant-root colonizer Pseudomonas putida can tolerate high levels of endogenous and exogenous oxidative stress. Yet, the ultimate reason of such phenotypic property remains largely unknown. To shed light on this question, metabolic network-wide routes for NADPH generation—the metabolic currency that fuels redox-stress quenching mechanisms—were inspected when P. putida KT2440 was challenged with a sub-lethal H2O2 dose as a proxy of oxidative conditions. 13C-tracer experiments, metabolomics, and flux analysis, together with the assessment of physiological parameters and measurement of enzymatic activities, revealed a substantial flux reconfiguration in oxidative environments. In particular, periplasmic glucose processing was rerouted to cytoplasmic oxidation, and the cyclic operation of the pentose phosphate pathway led to significant NADPH-forming fluxes, exceeding biosynthetic demands by ~50%. The resulting NADPH surplus, in turn, fueled the glutathione system for H2O2 reduction. These properties not only account for the tolerance of P. putida to environmental insults—some of which end up in the formation of reactive oxygen species—but they also highlight the value of this bacterial host as a platform for environmental bioremediation and metabolic engineering.
Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2
Authors: Luo Xiang , Gong Hai-Biao , Gao Hua-Ying , Wu Yan-Ping , Sun Wan-Yang , Li Zheng-Qiu , Wang Guan , Liu Bo , Liang Lei , Kurihara Hiroshi , Duan Wen-Jun , Li Yi-Fang , He Rong-Rong 
Published: January 2021

AbstractDuring cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment. However, the phagocytosis mechanism that regulates the engulfment of ferroptotic cells remains unclear. Here, we establish a novel pathway for phagocytic clearance of ferroptotic cells that is different from canonical mechanisms by using diverse ferroptosis models evoked by GPX4 dysfunction/deficiency. We identified the oxidized phospholipid, 1-steaoryl-2-15-HpETE-sn-glycero-3-phosphatidylethanolamine (SAPE-OOH), as a key eat-me signal on the ferroptotic cell surface. Enriching the plasma membrane with SAPE-OOH increased the efficiency of phagocytosis of ferroptotic cells by macrophage, a process that was suppressed by lipoprotein-associated phospholipase A2. Ligand fishing, lipid blotting, and cellular thermal shift assay screened and identified TLR2 as a membrane receptor that directly recognized SAPE-OOH, which was further confirmed by TLR2 inhibitors and gene silencing studies. A mouse mammary tumor model of ferroptosis verified SAPE-OOH and TLR2 as critical players in the clearance of ferroptotic cells in vivo. Taken together, this work demonstrates that SAPE-OOH on ferroptotic cell surface acts as an eat-me signal and navigates phagocytosis by targeting TLR2 on macrophages.