bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone augmentation with autologous tooth shell in the esthetic zone for dental implant restoration: a pilot study
Authors: Li Shuyi , Gao Ming , Zhou Miao , Zhu Yibo 
Published: November 2021

Abstract
Objectives
To investigate the outcome and short-term follow-up of autogenous tooth shell (TS) grafting for bone augmentation in the esthetic zone, as well as stability and esthetics of implant-supported restoration.

Materials and methods
A total of 8 patients with 11 implants in 11 sites were enrolled in this study. All the horizontal and/or vertical bone defects in the esthetic zone were augmented by tooth shells, which were fixed laterally to the residual bone with osteosynthesis screws. The gap between the shell and residual bone was filled with Bio-Oss® granules. Four months after bone augmentation, dimensionally sufficient dental implants were inserted and implants-supported prostheses were made 3 months later. The esthetic outcome was evaluated by pink esthetic score (PES) and white esthetic score (WES) one year after prosthetic restoration. Horizontal ridge width (HRW) was assessed before and immediately after bone augmentation, as well as 4 and 19 months post-augmentation by radiography. The stability and absorption of TS grafts were evaluated at the 4th and 19th months post-augmentation.

Results
Though wound dehiscences occurred in 3 cases, secondary healings were obtained after TS modification and irrigation. The other 5 cases went through uneventful healing during the whole observation period. Radiographic examination showed that HRW was 8.01 ± 0.93 mm (median: 7.80, 95% CI 7.38, 8.64) 4 months after TS augmentation, which was statistically different compared to HRW (2.72 ± 1.73 mm) at the baseline. Mean HRW gain was 5.29 ± 2.03 mm (median: 4.60, 95% CI 3.92, 6.66). Three-dimensional bone volume in all the augmented sites was sufficient for dental implants insertion and prosthetic restoration. Follow-up of one year showed stable marginal bone around dental implants. The implant survival rate was 100%. HRW losses were 0.65 ± 0.43 mm (the 4th month) and 1.05 ± 0.54 mm (the 19th month) compared to HRW immediately after augmentation. The PES and WES of final prosthetic restorations were 8.09 ± 0.70 and 8.91 ± 0.54, respectively.

Conclusions
Autogenous tooth shell grafting is a reliable approach for bone augmentation in the esthetic zone for dental implant treatment, allowing for favorable stability and esthetic outcome of implant-supported prosthesis within the one-year follow-up period.
Determinants of growth monitoring and promotion service utilization among children 0–23 months of age in northern Ethiopia: unmatched case-control study
Authors: Dagne Samuel , Aliyu Jemal , Menber Yonatan , Wassihun Yosef , Petrucka Pammla , Fentahun Netsanet 
Published: November 2021

Abstract
Background
One of the strategies to promote child health and reduce child mortality is growth monitoring and promotion services. But, there is limited information on determinants of Growth Monitoring and Promotion service utilization.

Objective
To identify determinants of growth monitoring and promotion (GMP) service utilization among children 0–23 months of age in Legambo district, South Wollo zone, Northern Ethiopia, 2020.

Methods
Community based un-matched case-control study was conducted on 363 (91 cases and 272 controls) study participants from March 15 to April 15, 2020. A multi-stage sampling technique was employed to select the study participants. Bivariable and multivariable logistic regressions were performed and an adjusted odds ratio with 95% confidence intervals was estimated to identify determinants of GMP service utilization.

Results
A total of 358 mothers (89 cases and 269 controls) with 98.6% response rate were included in the study. The mean (±SD) age of child was 11.66(±6.29) months among controls and 15.02 (±6.06) months among cases. Good maternal knowledge (AOR) = 2.42; 95% CI: 1.23, 4.75), favorable attitude (AOR = 2.45; 95% CI; 1.20, 4.98), counseling on GMP (AOR = 2.34; 95% CI; 1.19, 4.56), attending ante natal care services (AOR = 2.46; 95% CI: 1.18, 5.16), index child age 12–17 months (AOR = 3.45; 95% CI: 1.26, 9.41) and 18–23 months (AOR = 4.38; 95% CI: 1.53, 12.49), and short distance to health facilities (AOR = 4.53; 95% CI; 1.99, 10.28) were determinants of GMP service utilization.

Conclusion
Index child age, good knowledge, favorable attitude, attending antenatal care services, receiving nutritional counseling, and a short distance to health facility were determinants of GMP service utilization. Nutritional interventions should emphasize nutritional counseling and accessibility of growth monitoring and promotion services.
Perspectives of engagement in distance debriefings
Authors: Mosher Cynthia J. , Morton Alex , Palaganas Janice C. 
Published: November 2021

Abstract
Background
The COVID-19 pandemic propelled remote simulation and online distance debriefings. Like in-person debriefings, educators seek to facilitate reflective learning conversations, yet, in the online setting, educators face challenges to learner engagement that differ considerably from in-person debriefing.

Methods
We performed a thematic analysis of fourteen semi-structured interviews conducted with fourteen participants who had experience with virtual debriefing as an educator or as a learner. We explored the experiences and perceptions of both educators and learners to provide a more in-depth understanding of the factors that influence engagement in online distance debriefing.

Results
Our study identified the challenges online distance debriefing poses for educators and learners. We found ten themes that support the Community of Inquiry (CoI) theoretical framework and provided additional considerations related to internal and external factors of engagement, including the influence of the simulation, false engagement, and self-presence.

Conclusions
We believe these findings can inform the design and facilitation of online debriefings to help provide educators with guidance and innovative solutions to best engage their learners in the challenging online environment.
Psychosocial assessment and quality of life assessment in children with congenital heart in a developing country
Authors: Mohsen Aly Abdel , Kassem Mona Gamal , Antonios Manal A.-M. 
Published: November 2021

Abstract
Background
Few studies have examined the clinical utility of a brief psychosocial screening questionnaire and assessing the health-related quality of life as part of routine care in a pediatric cardiology clinic.

Subject and methods
A cross-sectional study was conducted over 6 months duration involving 224 patients with congenital heart diseases (CHD) aged 4–18 years and their parents to fulfill Pediatric Symptom Checklist (PSC) and Health related – Quality Of Life (HR-QOL) score. Statistical analysis of reliability of these scores among the studied population was carried using Cronbach’s alpha value.

Results
The studied population with CHD, aged 4–18 years with a mean ± standard deviation of 99.48 ± 43.37 months. They were 54.5% males (n = 122) and 45.5% females (n = 102). Internalizing problems were identified by PSC in 12.95% of patients (n = 29), Cyanosis was found to be the only significant independent risk factor for developing internalizing defects (p < 0.001). Quality of school functioning was the most affected domain in HR-QOL. While, the quality of social functioning remained good in the majority of cases. Cronbach’s alpha value coefficient of PSC and HR-QOL scores were 0.846 and 0.900 respectively, reflecting good to excellent reliability of these scores within the studied population.

Conclusions
Children with CHD have increased need for psychosocial assessment for improvement of their quality of life.
Depot Pure GnRH Antagonist for Long-term Treatment of Ovarian Hyperthecosis Monitored by Multisteroid LCMS Profiling
Authors: Ni Huajing , Schmidli Robert , Savkovic Sasha , Strasser Simone I , Hetherington Julie , Desai Reena , Handelsman David J 
Published: November 2021

Abstract
Ovarian hyperthecosis (OHT), severe hyperandrogenism after menopause in the absence of ovarian or adrenal tumors, is usually treated by surgical excision. We report a 58-year-old woman presenting with severe hyperandrogenism (serum testosterone 15.7-31.0 nmol/L, normal female &lt;1.8 nmol/L) with menopausal gonadotropins and virilization but no adrenal or ovarian lesions. Multisteroid profiling by liquid chromatography mass spectrometry (LCMS) of adrenal and ovarian vein samples identified strong gradients in the left ovarian vein (10- to 30-fold vs peripheral blood in 17OHP4, 17 hydroxyprogesterone, 17 hydroxypregnenolone, androstenedione, testosterone, dehydroepiandrosterone) but the right ovarian vein could not be cannulated with the same findings in a second ovarian vein cannulation. OHT diagnosis was confirmed by an injection of a depot pure gonadotropin-releasing hormone (GnRH) antagonist (80 mg Degarelix, Ferring) producing a rapid (&lt;24 hour) and complete suppression of ovarian steroidogenesis as well as serum luteinizing hormone and follicle-stimulating hormone lasting at least 8 weeks, with reduction in virilization but injection site reaction and flushing and vaginal spotting ameliorated by an estradiol patch. Serum testosterone remained suppressed at 313 days after the first dose despite recovery of menopausal gonadotropins by day 278 days. This illustrates use of multisteroid LCMS profiling for confirmation of the OHT diagnosis by ovarian and adrenal vein sampling and monitoring of treatment by peripheral blood sampling. Injection of a depot pure GnRH antagonist produced rapid and long-term complete suppression of ovarian steroidogenesis maintained over 10 months. Hence a depot pure GnRH antagonist can not only rapidly confirm the OHT diagnosis but also induce long-term remission of severe hyperandrogenism without surgery.
Average IGF-1 Prediction for Once-Weekly Lonapegsomatropin in Children With Growth Hormone Deficiency
Authors: Lin Zhengning , Shu Aimee D , Bach Mark , Miller Bradley S , Rogol Alan D 
Published: November 2021

Abstract

Context
Serum insulin-like growth factor 1 (IGF-1) levels are relatively constant in somatropin-treated children with growth hormone deficiency (GHD), and guide dose adjustments for clinical efficacy and long-term safety. IGF-1 levels following treatment with long-acting growth hormones such as lonapegsomatropin (lonapegsomatropin-tcgd, TransCon hGH), a once-weekly somatropin prodrug, exhibit a characteristic profile over the dosing interval.

Objective
This study aimed to develop a method to predict average IGF-1 in lonapegsomatropin-treated GHD children to interpret IGF-1 data based on a single sample obtained any time at steady state.

Methods
A population nonlinear mixed-effect pharmacodynamic model for IGF-1 was developed based on 2 randomized, open-label trials of TransCon hGh in GHD children and used to develop a linear mixed model with Taylor series to fit simulated IGF-1 profiles of lonapegsomatropin-treated children.

A total of
49 896 IGF-1 sample data simulated from 105 lonapegsomatropin-treated GHD children were utilized for the final prediction model. The dosage range of TransCon hGh was 0.14 to 0.30 hGH mg/kg/week, and weekly average IGF-1 was calculated using IGF-1 profiles simulated from the nonlinear pharmacodynamic model. Predicted average IGF-1 was obtained by linear mixed model with Taylor series.

Results
The nonlinear mixed-effect model provided satisfactory model fit. The linear mixed model with Taylor series fit simulated IGF-1 data well, with a relatively straightforward prediction formula. IGF-1 values sampled at ~4.5 days post-dose coincided with weekly average IGF-1 at steady state.

Conclusion
A formula to predict average IGF-1 from a single sample of IGF-1 at steady state was established to aid clinicians in interpreting IGF-1 levels in GHD children administered lonapegsomatropin.
Πληροφοριακά Μέσα, Ανθρωπόκαινος Εποχή, Καθεστώτα Μετα-αλήθειας
Authors: Κυριακόπουλος Λέανδρος , Πετρίδης Πέτρος 
Published: November 2021

Ποιος είναι ο αντίκτυπος της (ανα-)μεσοποίησης του φυσικού και κοινωνικού κόσμου από τα πληροφοριακά συστήματα; Πως διερευνούμε τον ρόλο των βιο-πληροφοριακών και τεχνο-κοινωνικών μέσων στην εργασία, στη πολιτική, στις κοινωνικές σχέσεις, στη συγκρότηση του σώματος, στην άρθρωση της υποκειμενικότητας, στη γνώση, και στις πλανητικής κλίμακας μετατοπίσεις στο περιβάλλον και τη διακυβέρνηση;Το παρόν κείμενο - αντι εισαγωγικού σημειώματος - φιλοδοξεί να θέσει κάποιες βάσεις που θα σκιαγραφούν ένα θεωρητικό και επιστημολογικό πεδίο για τη διεπιστημονική προσέγγιση των πολιτισμικών μετασχηματισμών του 21ου αιώνα. Το κείμενο επιχειρεί να χαρτογραφήσει το αντικείμενο του περιοδικού όπως αυτό σημαδεύεται από τους πολιτικούς μας χρόνους, και από την ανάδυση νέων (έμβιων και μη) τεχνο-κοινωνικών μορφών ζωής και των τεχνικών διακυβέρνησής τους.
Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach
Authors: Jadot Laurent , Judong Aurelie , Canivet Jean-Luc , Lorenzo Villalba Noel , Damas Pierre 
Published: November 2021

We report a case of ceftriaxone-induced encephalopathy correlated with high cerebrospinal fluid concentration. Neurotoxicity of cephalosporin is increasingly reported, especially regarding fourth-generation cephalosporins. The factors influencing the corticospinal fluid (CSF) concentration are plasma concentration, liposolubility, ionization, molecular weight, protein binding and efflux. In our patient, high levels of ceftriaxone (27.9 mg/l) were found in the CSF. β-lactam associated neurotoxicity is mainly related to similarities between GABA and β-lactam ring. Because of disparate CSF/plasma ratio and blood-brain barrier efflux among patients, plasmatic drug monitoring probably cannot be used as a surrogate of CSF concentration. This is, as we know, the first case of described ceftriaxone-induced encephalopathy associated with an objective excessive cerebrospinal concentration.
Retention and Spread Capability of Impacted Droplets with Surfactant and Hydrocolloid Based Adjuvants
Authors: Abbott JohnPaul R. , Zhu Heping , Jeon Hongyoung 
Published: November 2021

HighlightsRetention and spread of droplets with seven adjuvants were investigated on flat leaves.Surface tension of spray solutions, leaf wettability, and roughness strongly affected droplet retention and spread.Complete droplet retention occurred on hydrophilic leaves with all adjuvants and concentrations.High retention and spread on superhydrophobic leaves were achieved with the organo-silicone adjuvant.No retention occurred on superhydrophobic leaf surfaces with the hydrocolloid polymer adjuvant.Abstract. To optimize spray application efficiency, it is necessary to understand how the addition of adjuvants modifies the deposition properties of spray droplets on leaf surfaces due to variations in adhesive characteristics, such as roughness and wettability. Retention and spread of droplets with seven commercially available adjuvants were tested and compared at different concentrations. Tests were conducted with three leaf surfaces ranging in roughness and wettability from very smooth and hydrophilic to very rough and superhydrophobic. The adjuvants were formulated with non-ionic surfactant, crop oil, seed oil, organo-silicone, hydrocolloid polymer, or combinations of these agents as primary ingredients. Droplets of approximately 340 µm diameter were emitted from a streamed mono-sized generator. Droplet impact and spread were recorded with a 3D imaging system consisting of three high-speed digital cameras and analyzed using 3D motion analysis software. Retention and spread were determined by comparing droplet liquid volumes and droplet cross-sectional areas before and after impact, respectively. The surface tension of spray solutions and wettability of leaf surfaces strongly affected droplet retention. Droplets with lower surface tension were more likely to achieve high retention than those with higher surface tension. Droplet retention generally decreased with increasing leaf roughness-wettability. All droplets with and without adjuvants achieved 100% retention on the hydrophilic leaf surface. Addition of non-ionic, oil, or organo-silicone based adjuvants in the spray solution improved droplet retention on hydrophobic leaves, while the organo-silicone based adjuvant achieved the highest retention on superhydrophobic leaf surfaces. Droplet retention with the hydrocolloid polymer adjuvant was generally comparable to the other six adjuvants on the hydrophilic leaves and on the hydrophobic leaves with intermediate roughness and wettability but failed to achieve any retention on the superhydrophobic leaves. To improve droplet retention and adhesion, selection of adjuvants representing the non-ionic, oil, organo-silicone, blended, or hydrocolloid-based additives for enhancing spray solution performance must comply with the leaf surface characteristics. Keywords: Droplet rebound, High-speed imaging, Leaf wettability, Pesticide droplet deposition, Topography parameters.
DRAINMOD-P: A Model for Simulating Phosphorus Dynamics and Transport in Drained Agricultural Lands: I. Model Development
Authors: Askar Manal H. , Youssef Mohamed A. , Vadas Peter A. , Hesterberg Dean L. , Amoozegar Aziz , Chescheir George M. , Skaggs R. Wayne 
Published: November 2021

HighlightsDRAINMOD-P has been developed to simulate phosphorus (P) dynamics in drained croplands.Key hydrological and biochemical processes affecting P cycling are represented in the model.The model predicts surface and subsurface P losses as affected by weather, soil, and management factors.Abstract. High phosphorus (P) loads to streams and lakes can promote harmful algae blooms and cause water quality deterioration. Recent research has identified subsurface drainage as an important pathway for the transport of dissolved P from drained croplands to receiving surface water bodies, particularly when macropore flow contributes a considerable portion of the subsurface drainage outflow. Currently, a few models are capable of simulating P dynamics in poorly drained soils with artificial drainage systems. The objective of this study was to develop DRAINMOD-P, a field-scale, process-based model that simulates P cycling and transport in drained croplands. Processes represented in the model include atmospheric deposition, organic and inorganic fertilizer applications, plant uptake, sediment-bound and dissolved P losses in both surface runoff and subsurface drainage, tillage practices, and P mineralization and immobilization. The model predicts P losses under different management practices, climatic conditions, drainage systems, and crop rotations. The model is an extension to the nitrogen model DRAINMOD-NII, with full integration of the nitrogen and P model components. DRAINMOD-P uses the recently modified hydrology component that simulates macropore flow. A soil erosion component, based on the RUSLE approach, has been incorporated into the model to estimate sediment loss and associated particulate P loss. Sediment deposition in tile drains is considered to quantify particulate P settling in the drainage system. In this article, we review the approaches used in DRAINMOD-P for simulating P-related processes. Model testing against field-measured data from a subsurface-drained field in northwest Ohio is presented in a companion article. Keywords: Best management practices, Phosphorus model, Phosphorus processes, Soil erosion, Water quality modeling.
An Automatic Handheld Device for Firmness Measurement of Fruit with Edible Peel Based on Resistance Sensing: A Case Study of Peaches
Authors: Wang Dachen , Feng Zhe , Cui Di 
Published: November 2021

HighlightsA handheld device was developed for automatic on-site measurement of fruit firmness.The prototype device achieved better performance than a typical commercial penetrometer.Two commonly used firmness-related parameters could be predicted based on the prototype readings.The distribution and changes of firmness could be visualized based on 3D models of the prototype readings.Abstract. Firmness is an important indicator of fruit quality. The devices for on-site fruit firmness measurement need to be portable, low-cost, lightweight, reliable, and flexible. Existing portable devices can provide firmness-related parameters, but their measurement results cannot be converted to each other. Their measurement results are also susceptible to operator error due to the manual measurement process. To solve this problem, a prototype handheld device was developed based on sensing fruit resistance to achieve automatic on-site firmness measurement of fruit with edible peel and provide commonly used firmness-related parameters. The prototype’s precision was verified by analyzing the repeatability and reproducibility of the measurement results with four Shore hardness blocks. The relative standard deviations (RSDs) of the results obtained by the same operator were less than 0.61%, and there was no significant difference among the results obtained by different operators (p &lt; 0.05), which indicated that the prototype could provide reliable measurement results. A case study of peaches was performed, and the results showed that (1) the prototype had better performance than a commercial penetrometer, (2) two commonly used firmness-related parameters could be predicted based on regression models between a texture analyzer and the prototype readings (R2P = 0.908 and RMSEP = 4.191 N for maximum force; R2P = 0.923 and RMSEP = 1.613 N mm-1 for initial slope), (3) changes in the prototype readings for peaches during growth corresponded with the growth characteristics, and (4) the distribution and changes of peach firmness over time could be visualized based on 3D models of the prototype readings. Keywords: Automatic, Fruit firmness, Handheld device, High precision, Peach.
Image-matching assisted dual-frequency phase-sensitive optical time domain reflectometry
Authors: Dexin Ba , Ayana Lamessa A. , Ying Wang , Long Wang , Qi Chu , Yong kang Dong 
Published: November 2021

An image-matching assisted dual-frequency phase-sensitive optical time domain reflectometry (

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) is proposed and demonstrated. Compared to the conventional dual-frequency

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, which retrieves data via curve matching, the proposed scheme can effectively improve the temporal resolution and measurement precision while keeping the spatial resolution without additional hardware. In the experiments, with a 10 s temporal window, the proposed scheme realized the same measurement precision as the conventional method that used a 40 s window, suggesting a fourfold improvement of temporal resolution. When both used the 10 s temporal window, the measurement error was suppressed from 21.4% to 1.2% in the sensing for a 2 m hot zone at the end of a 90-m fiber.