bluuebunny/crossref_metadata_2025_split huggingface dataset:
First record of a tomistomine crocodylian from Australia
Authors: Ristevski Jorgo , Price Gilbert J. , Weisbecker Vera , Salisbury Steven W. 
Published: June 2021

AbstractBased on the known fossil record, the majority of crocodylians from the Cenozoic Era of Australia are referred to the extinct clade Mekosuchinae. The only extant crocodylians in Australia are two species of Crocodylus. Hence, the viewpoint that Crocodylus and mekosuchines have been the only crocodylians inhabiting Australia during the Cenozoic has remained largely undisputed. Herein we describe Australia’s first tomistomine crocodylian, Gunggamarandu maunala gen. et sp. nov., thus challenging the notion of mekosuchine dominance during most of the Cenozoic. The holotype specimen of Gunggamarandu maunala derives from the Pliocene or Pleistocene of south-eastern Queensland, marking the southern-most global record for Tomistominae. Gunggamarandu maunala is known from a large, incomplete cranium that possesses a unique combination of features that distinguishes it from other crocodylians. Phylogenetic analyses place Gunggamarandu in a basal position within Tomistominae, specifically as a sister taxon to Dollosuchoides from the Eocene of Europe. These results hint at a potential ghost lineage between European and Australian tomistomines going back more than 50 million years. The cranial proportions of the Gunggamarandu maunala holotype specimen indicate it is the largest crocodyliform yet discovered from Australia.
Simple and versatile imaging of genomic loci in live mammalian cells and early pre-implantation embryos using CAS-LiveFISH
Authors: Geng Yongtao , Pertsinidis Alexandros 
Published: June 2021

AbstractVisualizing the 4D genome in live cells is essential for understanding its regulation. Programmable DNA-binding probes, such as fluorescent clustered regularly interspaced short palindromic repeats (CRISPR) and transcription activator-like effector (TALE) proteins have recently emerged as powerful tools for imaging specific genomic loci in live cells. However, many such systems rely on genetically-encoded components, often requiring multiple constructs that each must be separately optimized, thus limiting their use. Here we develop efficient and versatile systems, based on in vitro transcribed single-guide-RNAs (sgRNAs) and fluorescently-tagged recombinant, catalytically-inactivated Cas9 (dCas9) proteins. Controlled cell delivery of pre-assembled dCas9-sgRNA ribonucleoprotein (RNP) complexes enables robust genomic imaging in live cells and in early mouse embryos. We further demonstrate multiplex tagging of up to 3 genes, tracking detailed movements of chromatin segments and imaging spatial relationships between a distal enhancer and a target gene, with nanometer resolution in live cells. This simple and effective approach should facilitate visualizing chromatin dynamics and nuclear architecture in various living systems.
Curcubinoyl flavonoids from wild ginseng adventitious root cultures
Authors: Liu Qing , Kim Seon Beom , Jo Yang Hee , Ahn Jong Hoon , Turk Ayman , Kim Da Eun , Chang Bo Yoon , Kim Sung Yeon , Jeong Cheol-Seung , Hwang Bang Yeon , Park So-Young , Lee Mi Kyeong 
Published: June 2021

AbstractWild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new secondary metabolites. Chromatographic fractionation of wild ginseng adventitious root cultures led to the isolation of eleven compounds. The chemical structures of isolated compounds were identified as four known flavanone derivatives (1–4), one new curcubinoyl derivative, jasmogin A (5) and six new curcubinoyl-flavanone conjugates, jasmoflagins A-F (6–11) by extensive spectroscopic analysis. Newly isolated curcubinoyl derivatives showed inhibitory activity against lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages. Therefore, our present study suggested that elicitor stimulated plant cell cultures might contribute to the production of new metabolites.
Treating Velopharyngeal Insufficiency in a Case of Substance Abuse: A New Client Population
Authors: Ruscello Dennis M. , Armeni Mark 
Published: June 2021

Objective:A case study is presented to illustrate the management of a patient who presented with significant tissue damage of the soft palate due to substance abuse, which involved the inhalation of drugs.Method:The patient was seen in a university medical center cleft palate clinic upon referral from a mental health facility with reported speech and swallowing problems. Perceptual and physiologic speech testing, a behavioral swallowing assessment, and other interdisciplinary assessments were conducted to confirm the patient's complaints and develop a treatment plan.Results:A speech appliance was fabricated to correct the defect and follow-up testing showed improvement in both speech and swallowing skills. Perceptual assessment indicated improved resonance balance and reduction in audible nasal emission, while physiologic testing revealed decreased nasal airflow. The team successfully implemented a plan to correct the patient's speech, resonance, and swallowing problems.Conclusions:Substance abuse is now a significant national crisis and patients may need a range of services depending on their complex of problems. Some individuals may need assistance with speech, resonance, and swallowing disorders and require prosthetic intervention provided via interdisciplinary management from a cleft palate team.
Adaptive sliding mode disturbance observer–based funnel trajectory tracking control of quadrotor with external disturbances
Authors: Xu Gang , Xia Yuanqing , Zhai Di‐Hua , Cui Bing 
Published: June 2021

AbstractThis paper studies trajectory tracking control problem of quadrotor in the presence of external disturbances. A new control scheme integrating adaptive sliding mode disturbance observer (ASMDO) with backstepping funnel control is designed in both position loop and attitude loop. Adaptive sliding mode disturbance observer is utilized to estimate and compensate the external disturbances of quadrotor system, which relaxed the upper bound requirement in conventional sliding mode disturbance observer (SMDO) whilst adapting the gain of discontinuous term to a level as small as possible for consideration of chattering mitigation. The modified funnel function not only guarantees the dynamic quality in the tracking process but also avoids derivative operation of Euclidian norm of tracking error in the backstepping design. To guarantee stabilization of closed‐loop system, Lyapunov stability criterion is utilized in the overall controller design process. Finally, the effectiveness and superiority of the proposed scheme are illustrated by simulation results.
Research on the assessment of the capacity of urban distribution networks to accept electric vehicles based on the improved TOPSIS method
Authors: Zhang Meixia , Sun Quanjie , Yang Xiu 
Published: June 2021

AbstractThis study proposes a TOPSIS‐based method for assessing the ability of distribution networks to accept electric vehicles. This method establishes an assessment index system in terms of the rationality, safety, and economy of the distribution network operation, and assesses the capacity of the distribution network in all aspects. Firstly, a fuzzy theory‐based model of users' charging psychology under the influence of time‐of‐use electricity price was constructed, and the spatio‐temporal distribution of EV charging loads in the target area was predicted using travel chain theory and Monte Carlo methods. Secondly, considering the rationality, safety and economy of the distribution network operation, a comprehensive evaluation index system for acceptability has been constructed. Then, a comprehensive weighting method for evaluation indexes based on AHP and entropy weight method is proposed, and the improved TOPSIS is used to evaluate the acceptance capacity of the distribution network when EV charging loads are connected in different ways. Finally, a typical IEEE33 distribution network is used to simulate the time and space distribution of the charging load, and taking the charging load access schemes proposed in this paper to verify the effectiveness of the evaluation method.
Predictive modelling of fuel shortages during hurricane evacuation: An epidemiological approach
Authors: Islam Sabique , Parr Scott , Prazenica Richard , Liu Dahai , Namilae Sirish 
Published: June 2021

AbstractHigh‐volume evacuations, disruptions to the supply chain, and fuel hoarding from non‐evacuees have led to localized fuel shortages lasting several days during recent hurricanes. While news reports mention fuel shortages in past hurricanes, the crowdsource platform Gasbuddy has quantified the fuel shortages in the recent hurricanes. The analysis of this fuel shortage data suggested fuel shortages exhibited characteristics of an epidemic. Here, a Susceptible‐ Infected‐Recovered (SIR) epidemic model is developed to study the evolution of fuel shortage during a hurricane evacuation. Additionally, we apply optimal control theory to identify an effective intervention strategy. The study found a linear correlation between traffic demand during the evacuation of Hurricane Irma and the resulting fuel shortage data. This correlation is used in conjunction with the Statewide Regional Evacuation Study Program (SRESP) surveys to estimate the evacuation traffic and fuel shortages for potential hurricanes affecting south Florida. Results indicate that evacuation of Miami‐Dade County in the event of a Category‐3 hurricane landfall in the region, could lead to fuel shortages in up to 90% of the local refuelling stations. The model indicates that this reduces to 28% by providing relief to 75% of the gas stations during the first two days of the evacuation.
Numerical simulation of parametric resonance in point absorbers using a simplified model
Authors: Kurniawan Adi , Tran Thanh Toan , Brown Scott A. , Eskilsson Claes , Orszaghova Jana , Greaves Deborah 
Published: June 2021

AbstractParametric resonance is a non‐linear phenomenon in which a system can oscillate at a frequency different from its exciting frequency. Some wave energy converters are prone to this phenomenon, which is usually detrimental to their performance. Here, a computationally efficient way of simulating parametric resonance in point absorbers is presented. The model is based on linear potential theory, so the wave forces are evaluated at the mean position of the body. However, the first‐order variation of the body's centres of gravity and buoyancy is taken into account. This gives essentially the same result as a more rigorous approach of keeping terms in the equation of motion up to second order in the body motions. The only difference from a linear model is the presence of non‐zero off‐diagonal elements in the mass matrix. The model is benchmarked against state‐of‐the‐art non‐linear Froude–Krylov and computational fluid dynamics models for free decay, regular wave, and focused wave group cases. It is shown that the simplified model is able to simulate parametric resonance in pitch to a reasonable accuracy even though no non‐linear wave forces are included. The simulation speed on a standard computer is up to two orders of magnitude faster than real time.
Spatial demand forecasting based on smart meter data for improving local energy self‐sufficiency in smart cities
Authors: Miyasawa Ayumu , Akira Shogo , Fujimoto Yu , Hayashi Yasuhiro 
Published: June 2021

AbstractThe use of distributed energy resources (DERs) in a city contributes to the net zero CO2 of a city. However, the spatially uneven distribution of power demand and surplus electricity causes congestion in the grid system, making wide‐area operation difficult. The concept of local energy self‐sufficiency via energy management, in which batteries or electric vehicles are charged using power generated by DERs and discharged to neighbouring consumers, is expected to be a way to avoid grid conjunction while maximizing the use of DERs. For efficient local energy self‐sufficiency, it is necessary to identify where and when future power surpluses and shortages will occur within a city and optimize battery operation according to demand. Forecasts that focus only on representative points of a city may be less reproducible in diversity in the power demand transition for individual consumers in local parts of cities. Electricity smart meters that monitor power demand every 30 min from each consumer are expected to help predict the spatiotemporal distribution of power demand to achieve efficient local energy self‐sufficiency. The significance of reflecting regional characteristics in forecasting spatiotemporal distribution of power demand is demonstrated using actual data obtained by smart meters installed in Japanese cities. The results suggest that the forecast approach, which considers the daily periodicity of power demand and weather conditions, obtains high prediction accuracy in predicting power demand in meshed local areas in the city and derives results precisely reproducing the spatiotemporal behaviours of power demand.
Nahrungsmittelallergien im Beratungsalltag – Erwartungen kontra Fakten
Authors: Enzel Ulrich 
Published: June 2021

ZusammenfassungNein, auch dieser Artikel wird das größte Rätsel um die Nahrungsmittelallergien nicht lösen können: Warum glaubt jeder 5. Deutsche, an (zumindest einer) solchen zu leiden, wo doch nur 6–8 % der Säuglinge, 4,2 % der Kinder und 1–3,7 % der Erwachsenen tatsächlich daran erkrankt sind? Umso wichtiger ist es, den Fokus auch auf die unterschiedlichen Krankheitsbilder zu richten, mit denen diese Allergieform verwechselt werden kann – ja, die sogar allzu häufig verkannt und daher nicht therapiert werden.
Trans*-Sexualität neu denken: Eine partizipative Interviewstudie zu gelingender Sexualität ohne Genitalangleichung
Authors: Hamm Jonas A. , Nieder Timo O. 
Published: June 2021

Zusammenfassung
Einleitung Studien zur Sexualität von trans* Personen sind häufig durch das heteronormative Bias geprägt, alle trans* Personen würden eine Genitalangleichung anstreben, um penil-vaginalen penetrativen Geschlechtsverkehr ausüben zu können, als (trans*) Mann in der insertiven, als (trans*) Frau in der aufnehmenden Rolle. Diese Studie untersucht erstmals die Sexualität von trans* Personen, die keine Genitalangleichung anstreben und mit ihrer Sexualität zufrieden sind.
Forschungsziele Ziel der Studie ist es, die individuelle Sexualität von Menschen dieser Personengruppe zu beleuchten und die intrapsychischen, interaktionellen und kollektiven Ressourcen zu analysieren, auf die sie dabei zurückgreifen. Darunter fallen auch Strategien, um den scheinbaren Widerspruch von Geschlechtsidentität und Körperlichkeit zu überbrücken.
Methoden Es wurden sechs leitfadengestützte qualitative Interviews durchgeführt und mithilfe einer inhaltlich strukturierenden qualitativen Inhaltsanalyse ausgewertet. Die Studie beinhaltete verschiedene partizipative Elemente. So wurden die Ergebnisse im Rahmen einer partizipativen Feedbackschleife durch die Teilnehmenden kommunikativ validiert.
Ergebnisse Die Teilnehmer_innen berichten von vielfältigen, genitalen wie non-genitalen sexuellen Praktiken, die unabhängig von den damit assoziierten Geschlechterrollen stattfinden. Dabei greifen sie auf verschiedene Ressourcen und Strategien zurück. Insbesondere wird die geschlechtsanzeigende Funktion von Genitalien auf drei Ebenen dekonstruiert: individuell durch die Teilnehmenden selbst, interaktionell über die Anerkennung ihrer Geschlechtsidentität durch sexuelle Partner_innen und kollektiv durch die Communitys, in denen sie sich bewegen.
Schlussfolgerung Die Studie entkräftet die oft unhinterfragte Vorannahme, dass trans* Personen per se ihre Genitalien nur widerwillig oder unter Erfahrungen von körperlicher Dysphorie in der Sexualität einsetzen. Mit den richtigen Ressourcen müssen sexuelle Rolle, Genitalienstatus und Geschlechtsidentität nicht stereotyp zusammenfallen, um gelingende Sexualität zu praktizieren.
Skala zur Messung der Qualität der Hebammenbegleitung während der Geburt aus der Perspektive der Nutzerinnen: Entwicklung und Validierung von MMAYbirth
Authors: Peters Mirjam , Kolip Petra , Schäfers Rainhild 
Published: June 2021

ZusammenfassungIn der Evaluation der Gesundheitsversorgung spielt zunehmend auch die Perspektive der Nutzerinnen eine bedeutsame Rolle. In der vorliegenden Studie wurde der MMAYbirth entwickelt, ein Fragebogen, der die Qualität der Versorgung während der Geburt durch Hebammen aus der Perspektive der Frauen misst. Der Fragebogen wurde anhand psychometrischer Kennwerte geprüft (n = 1588). MMAYbirth umfasst 21 Items in 4 Sub-Skalen. Er ist ein reliables und kurzes Instrument zur Bewertung der Qualität der Hebammenbegleitung während der Geburt. Es kann zur routinemäßigen Evaluation, zum Vergleich verschiedener Versorgungsmodelle und in der Interventionsforschung eingesetzt werden. Es unterstützt damit die Ausrichtung der Hebammenarbeit an den Bedürfnissen von Frauen und ihren Familien.
Human Absorbed Dose Evaluation of [177Lu]Lu-IBA as a Bone Palliative Candidate
Authors: Ranjbar Hassan , Pourhabib Zahra 
Published: June 2021

AbstractThe role of lutetium-177 among bone-seeking radionuclides in targeted therapy is noteworthy. The clinical pharmacokinetics of ibandronate (IBA) indicates that this bisphonate has powerful bone mineral affinity. The aim of this study was to evaluate of [177Lu]Lu-IBA efficacy as a new compound.The [177Lu]Lu-IBA was prepared by radiolabeling of IBA ligand to 177LuCl3 that was obtained by thermal neutron irradiation of enriched Lu2O3 sample. Produced [177Lu]Lu-IBA with high radiochemical purity was administered intravenously to mice. Biodistribution data were collected at 1, 4, 24, 48 h and 7 d post injections. With calculating accumulated activities in each organ and extrapolating mouse’s organs to human’s organs by the RADAR method and using OLINDA/EXM software the injected dose in various human organs was achieved.[177Lu]Lu-IBA was produced with radiochemical purity nearly 96 %. Its biodistribution data showed the high uptake and durability in the skeletal tissues without significant uptake in other major organs.The results showed that [177Lu]Lu-IBA has considerably good properties as a bone-seeking radiopharmaceutical and therefore can be a candidate for bone pain palliative therapy in skeletal metastases; however, further biological studies are still needed.
Medizinische Versorgungszentren als eingetragene Genossenschaft – ein Zukunftsmodell?
Authors: Reinwald Stefan , Hoffmann Felix 
Published: June 2021

Zusammenfassung
Ziel der Studie Das Ziel ist die Erhebung von Erfahrungen genossenschaftlicher MVZ in Deutschland und die Ermittlung weiteren Forschungsbedarfs.
Methodik Die Forschungsfrage wird mittels Inhaltsanalyse von Satzungen und Interviews unter Einbeziehung einschlägiger Regelungen aus Genossenschaftsgesetz und SGB V beantwortet.
Ergebnisse In Deutschland existierten am 14.02.2020 3 genossenschaftliche MVZ. Die Gründung einer Genossenschaft ist mit geringen Hürden verbunden, bietet aber später Vorteile wie die bessere Mitbestimmung und flexiblere Aufnahme von Mitunternehmern.
Schlussfolgerung Die Rechtsform der Genossenschaft bietet MVZ die Möglichkeit, resiliente Strukturen in der ambulanten Versorgung zu etablieren, die nicht dem Profitstreben von Investoren unterworfen sind.
Recent Strategies in Non-Heme-Type Metal Complex-Catalyzed Site-, Chemo-, and Enantioselective C–H Oxygenations
Authors: Uchida Tatsuya , Doiuchi Daiki 
Published: June 2021

AbstractC–H bonds are ubiquitous and abundant in organic molecules. If such C–H bonds can be converted into the desired functional groups in a site-, chemo-, diastereo-, and enantio-selective manner, the functionalization of C–H bonds would be an efficient tool for step-, atom- and redox-economic organic synthesis. C–H oxidation, as a typical C–H functionalization, affords hydroxy and carbonyl groups, which are key functional groups in organic synthesis and biological chemistry, directly. Recently, significant developments have been made using non-heme-type transition-metal catalysts. Oxygen functional groups can be introduced to not only simple hydrocarbons but also complex natural products. In this paper, recent developments over the last fourteen years in non-heme-type complex-catalyzed C–H oxidations are reviewed.1	Introduction2	Regio- and Chemo-Selective C–H Oxidations2.1	Tertiary Site-Selective C–H Oxidations2.2	Secondary Site-Selective C–H Oxidations2.3	C–H Oxidations of N-Containing Molecules2.4	C–H Oxidations of Carboxylic Acids2.5	Chemo- and Site-Selective Methylenic C–H Hydroxylations3	Enantioselective C–H Oxidations3.1	Desymmetrizations through C–H Oxidations3.2	Enantiotopic Methylenic C–H Oxygenations4	Conclusion
Short-Term Follow-Up of the PROSTALAC Implant for Primary Total Hip Arthroplasty in Patients with an Infected Native/Total Hip
Authors: Chia Jean , Roy Alfred , Jackman Emma , Inglis Mark , Wilson Christopher 
Published: June 2021

AbstractInfection after a total hip replacement (THR) is a significant complication for patients and is costly for health services. The two-stage Prosthesis with Antibiotic Loaded Acrylic (PROSTALAC) procedure has been the gold standard treatment for managing THR infections. The aim of this study is to evaluate using a one-stage PROSTALAC procedure as an alternative for patients who would otherwise not be able to undergo THR surgery due to a previous hip infection.We evaluated nine cases where the PROSTALAC implant was used in the native hip. The reasons for surgery, clinical results, and complications were reviewed. An Australian Orthopaedic Association National Joint Replacement Registry data report verified that no patients were revised outside of our local center.All patients reported symptomatic relief and satisfactory function, one patient had a peri-prosthetic fracture after experiencing a fall, and one patient underwent surgery for loosening of the joint. No cases were revised to another implant or had further infection. Minimum follow-up was 2 years.Our results suggest that this implant is useful in patients with osteoarthritis of the hip with a history of previous infection or chronic infection of the native hip.