bluuebunny/crossref_metadata_2025_split huggingface dataset:
Libéralisation des marchés laitiers et transformation des régimes de concurrence
Authors: Dervillé Marie 
Published: July 2021

Nous proposons de mobiliser le concept de régime de concurrence pour appréhender la co-évolution des stratégies individuelles et des régulations collectives et publiques dans un domaine d’activité particulier. Combinant l’institutionnalisme historique de John R. Commons aux apports de la théorie de la régulation et de la socio-économie, le régime de concurrence définit les marges de manœuvres individuelles des opérateurs (faisceau de droits de propriété) compte tenu des régulations sectorielles informelles (conceptions de contrôle) et formelles (structures de gouvernance) et des régulations publiques (règles de l’échange).Les résultats des recherches empiriques menées sur la transformation des secteurs laitiers français et allemands au cours des 60 dernières années montrent le rôle central joué par l’action collective dans la stabilisation des marchés, tant dans le cadre de politiques publiques interventionnistes (effectivité et extension du cadre réglementaire) que libérales (structuration d’ordres sectoriels). La différenciation régionale des régimes de concurrence ressort en Allemagne comme un levier essentiel d’adaptation à la libéralisation des marchés laitiers. Le verrouillage sectoriel national dans le cas français limite les possibilités régionales d’innovation et de création de valeur et freine la transition vers un régime de concurrence post-industriel.
BCL6B hypermethylation predicts metastasis and poor prognosis in early-stage hepatocellular carcinoma after thermal ablation
Authors: Li Xin , Guo Mingzhou , Yang Lili , Cheng Zhigang , Yu Xiaoling , Han Zhiyu , Liu Fangyi , Sun Qiang , Han Xianjing , Yu Jie , Liang Ping 
Published: July 2021

Aims:
The aim of this study was to evaluate the role of BCL6B methylation in the progression of early-stage hepatocellular carcinoma (HCC) after thermal ablation.

Settings and Design:
This is a retrospective study and written informed consent was obtained from all patients or their legal guardians.

Subjects and Methods:
Between October 2008 and December 2013, 73 patients with early-stage HCC within the Milan criteria, who received thermal ablation, were recruited.

Statistical Analysis Used:
Based on methylation-specific polymerase chain reaction, the relationship between BCL6B methylation and patient characteristics and prognosis was analyzed using univariate, multivariate, and Kaplan–Meier analysis.

Results:
The median follow-up period was 56 (8–110) months. For the BCL6B unmethylated group, the 1-, 3- and 5-year metastasis and overall survival (OS) rates after thermal ablation were 10.0%, 10.0%, and 40.0% and 100%, 100% and 90.0%, respectively. The 1-, 3-, and 5-year metastasis and OS rates of the methylated group were 23.8%, 66.7% and 88.9% and 66.2%, 71.4% and 41.3%, respectively. Levels of absolute count lymphocyte, serum cholinesterase and albumin in the BCL6B unmethylated group were higher than those in the methylated group (P = 0.020, 0.000, and 0.009, respectively). Kaplan–Meier analysis revealed that BCL6B methylation was related to metastasis and poor prognosis (P = 0.001 and 0.018, respectively). Univariate analysis revealed that BCL6B methylation was a risk factor for metastasis and poor prognosis (odds ratio [OR]: 5.663; 95% confidence interval [CI], 1.745–18.375, P = 0.004 and OR: 3.734; 95% CI, 1.151–12.110, P = 0.028, respectively). Multivariate analysis revealed that BCL6B methylation was an independent risk factor for metastasis (OR: 3.736; 95% CI, 1.000–13.963,P = 0.05) and not for prognosis (OR: 2.780; 95% CI, 0.835–9.250,P = 0.096).

Conclusions:
BCL6B methylation could be a valuable prognostic factor for metastasis and poor prognosis in early-stage HCC after thermal ablation, which is an independent risk factor for metastasis. Our findings provide insights for combining ablation and epigenetic therapy for patients with HCC.
Novel nomogram predicting cancer-specific survival and overall survival in patients with primary esophageal small-cell carcinoma
Authors: Li Jisheng , Yu Hejiang , Peng Ling , Li Li , Wang Xiangling , Hao Jing , Shao Na 
Published: July 2021

Background:
Small-cell carcinoma is a relatively infrequent pathological variety of esophageal cancer. In this study, a novel nomogram model was developed to evaluate the cancer-specific survival (CSS) and overall survival (OS) of patients with primary esophageal small-cell carcinoma (ESmCC).

Materials and Methods:
In total, 502 patients with primary ESmCC were identified based on data from 1973 to 2015 retrieved from the surveillance, epidemiology, and end results database. Clinical characteristics such as age at diagnosis, gender, race, site, tumor stage, surgery, radiotherapy, and chemotherapy were included for multivariate logistic analyses to predict CSS and OS. Nomogram models for the prediction of CSS and OS in ESmCC patients were tested with the concordance index (C-index) method and calibration curves.

Results:
From our multivariate analyses, race, stage, chemotherapy, and radiotherapy, but not surgery, were significantly associated with the CSS of ESmCC patients, while age at diagnosis, stage, chemotherapy, and radiotherapy were significantly associated with their OS. Nomograms were developed using age at diagnosis, race, gender, stage, surgery, radiotherapy, and chemotherapy to predict the two survival measures; these nomograms were verified as accurate in predicting OS and CSS in ESmCC patients, with C-index values of 0.736 and 0.731, respectively.

Conclusions:
By utilizing easily accessible clinicopathological information, we established a simple but useful tool for predicting the CSS and OS of ESmCC patients that could help to make personalized clinical decisions for patients with this rare malignancy.
The role of prostate-specific antigen and multiparametric magnetic resonance imaging in the diagnosis of granulomatous prostatitis induced by intravesical Bacillus Calmette–Guérin vaccine therapy in patients with nonmuscle invasive bladder cancer
Authors: Wang Zilong , Han Chenglin , Xu Yingkun , Yu Xiao , Kang Weiting , Xiang Yuzhu , Yuan Yanhua , Li Lianjun , Wang Muwen 
Published: July 2021

Aims:
This study aimed to evaluate the role of serum prostate-specific antigen (PSA) levels and multiparametric magnetic resonance imaging (mpMRI) in the diagnosis of granulomatous prostatitis (GP) induced by intravesical Bacillus Calmette–Guérin vaccine (BCG) therapy in patients with nonmuscle invasive bladder cancer (NMIBC).

Subjects and Methods:
We retrospectively analyzed eight patients with bladder cancer who underwent intravesical BCG therapy after transurethral resection of bladder tumor (TURBt) cancer. All these eight patients received 12-core transrectal ultrasound-guided prostate systemic biopsies. Clinical data on PSA with T1-weighted imaging (T1WI), T2WI, diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) on mpMRI were enrolled in the study. H and E and acid-fast staining was performed to pathologically prove GP.

Results:
Four of all eight cases were above 4 ng/ml total PSA (tPSA) levels and four cases were within normal ranges, while free PSA/tPSA levels decreased to lower than 16% in all patients. Every patient had hard prostatic nodules through digital rectal examination (DRE). All characters of prostate mpMRI did not show signal intensity (SI) of prostate cancer before BCG therapy but showed abnormal signals after BCG therapy. All nodular lesions showed equal SI on T1WI, lower SI on T2WI, higher SI on DWI, and lower SI on ADC after BCG therapy. Pathologic results were GP and acid-fast staining outcomes were positive in all biopsies.

Conclusions:
Perioperative serum PSA levels, prostate magnetic resonance imaging, and DRE may help in the diagnosis of GP induced by intravesical BCG therapy. In general, male patients with middle- and high-risk NMIBC are recommended to undertake DRE, PSA, and prostate mpMRI, if possible, before and after TURBt.
Ultrasound-guided percutaneous microwave ablation of bilateral renal cell carcinomas
Authors: Zhang Ruimin , Qi Erpeng , Liang Ping , Cheng Zhigang , Tan Shuilian , Han Zhiyu , Liu Fangyi , Yu Jie , Yu Xiaoling 
Published: July 2021

Objective:
To retrospectively review the safety and efficacy of ultrasound (US)-guided percutaneous microwave ablation (MWA) of bilateral renal cell carcinomas (BRCCs).

Patients and Methods:
In this study, eight patients of BRCCs with 20 lesions seen from November 2012 to October 2018 were enrolled retrospectively. The patients were treated with US -guided percutaneous MWA and were followed up with contrast-enhanced US and computed tomography or magnetic resonance imaging.

Results:
Technical success was achieved 20 tumors. The 18 lesions were performed to ablate 90%; 2 lesions were repeated because of detecting residual ablated tumor. Except six patients were noted fever, no severe complications occurred. The median follow-up time was 24 months (range 7–59 months). Among the eight patients, there was no local tumor recurrence in 6 of 8 completely ablated tumor lesions. One patient was retreated by MWA 6 months after ablation, and another was retreated after 19 months due to local tumor recurrence. No patients have obvious change of renal function and lost their life.

Conclusion:
US-guided percutaneous MWA is a beneficial treatment for BRCC.
A practical screening strategy for Lynch syndrome and Lynch syndrome mimics in colorectal cancer
Authors: Yao Zhi-Gang , Lv Bei-Bei , Jing Hai-Yan , Su Wen-Jing , Li Jia-Mei , Fan Hui , Zhao Miao-Qing , Qin Ye-Jun , Sun Xi-Chao 
Published: July 2021

Objectives:
The objective of the study is to provide an efficient and practical screening strategy to distinguish a broader spectrum of Lynch syndrome (LS) and LS mimics-associated colorectal cancer (CRC), including Lynch-like syndrome (LLS), constitutional mismatch repair-deficiency, familial CRC type X (FCCTX), and polymerase proofreading-associated polyposis syndrome.

Materials and Methods:
1294 cases of CRC samples were detected mismatch repair (MMR) status using immunohistochemistry (IHC) staining, in which the cases with MLH1-deficient CRC underwent BRAF mutation analysis by IHC. Following the personal and/or family history survey, next-generation sequencing (NGS) was used to detect gene variants.

Results:
1294 CRC patients were dichotomized into tumors caused by a deficient MMR (dMMR) system and a proficient MMR (pMMR) system after MMR status analysis. 45 patients with suspected sporadic dMMR CRC were then separated from MLH1-deficient CRC though BRAF mutation status analysis by IHC. Following the personal and/or family history survey for 1294 patients, as well as germline genetic testing by NGS, 34 patients were diagnosed as LS (8 cases), SLS (13 cases), LLS ( 6 cases), FCCTX (3 cases), and sporadic CRC (4 cases).

Conclusions:
Our screening strategy, which consists of clinical and molecular analyses, is expected to improve the screening efficiency and management for the LS and LS mimics.
Intermediate stage hepatocellular carcinoma
Authors: Liu Ying , Shi Menting , Chen Shuanggang , Wan Weiqi , Shen Lujun , Shen Binyan , Qi Han , Cao Fei , Wu Ying , Huang Tao , Chen Guanjian , Mo Jinqing , Ye Dongdong , Zhang Yinqi , Feng Ziqing , Fan Weijun 
Published: July 2021

Context and Aims:
The identification of inflammation-related prognostic heterogeneity in intermediate-stage hepatocellular carcinoma (HCC) can reveal more effective first-line treatments. Our study aimed to compare the intermediate-stage HCC patients' different inflammation-based scores in predicting their progression-free survival (PFS) after transarterial chemoembolization (TACE).

Materials and Methods:
We analyzed retrospectively a total of 128 intermediate-stage HCC patients who received first-line TACE treatment. We used the Cox-proportional hazards modeling to identify the independent prognostic factors. We compared the inflammation-based scores abilities to predict the PFS through the time-dependent receiver operating characteristic curves and area under the curves.

Results:
The multivariate analysis showed that tumor size and platelet-to-lymphocyte ratio (PLR) were the independent prognostic factors for PFS (P < 0.05). The PLR predicted the intermediate-stage HCC patients' PFS receiving the TACE treatment better than other inflammation-based scores (e.g., the neutrophil-to-lymphocyte ratio, the Glasgow Prognostic Score (GPS), the modified GPS, the Prognostic Index, the Prognostic Nutritional Index, the lymphocyte-to-monocyte ratio, and the systemic immune-inflammation index) (P < 0.05). An easy-to-use novel inflammation score based on tumor size – PLR-size score significantly improved the PFS prediction performance (P < 0.05).

Conclusions:
As a first-line treatment, TACE was not well suitable for all intermediate-stage HCC patients, while the PLR was a better inflammation-based score than others. Tumor size should be regarded as an essential variable in affecting intermediate-stage HCC patients' first-line treatment strategies.
Efficacy comparison between microwave ablation combined with radiation therapy and radiation therapy alone for locally advanced nonsmall-cell lung cancer
Authors: Song Pengyuan , Sun Wei , Pang Min , He Weina , Zhang Weihua , Sheng Lijun 
Published: July 2021

Purpose:
Comparing the efficacy and complications of microwave ablation (MA) combined with intensity-modulated radiation therapy (IMRT) and IMRT alone for locally advanced peripheral nonsmall-cell lung cancer (NSCLC).

Methods:
Retrospective analysis was conducted on 76 patients with locally advanced peripheral NSCLC undergoing chemotherapy and metastatic lymph node radiation therapy from June 2014 to June 2016. Either MA or IMRT was used to treat primary lesions. Thirty-four cases were treated with MA (MA group), 42 cases were treated with IMRT (IMRT group), and comparisons were made of the 1–3-year progression-free survival (PFS) and complications of the two groups.

Results:
The PFS of the MA group at 1, 2, and 3 years were 70.59% (24/34), 47.06% (16/34), and 35.29% (12/34), and the PFS of the IMRT group at the same intervals were 71.43% (30/42), 52.38% (22/42), and 35.71% (15/42), with no significant difference (χ2= 0.006, P = 0.936) (χ2= 0.213, P = 0.645) (χ2= 0.001, P = 0.970). Radiation-induced lung injury (RILI) occurred in 14.70% (5/34) of MA group patients, which was significantly lower than in the IMRT group 40.48% (17/42), but without grade II or above RILI.

Conclusion:
MA combined with IMRT in the treatment of locally advanced peripheral NSCLC was not inferior to the clinical effect of radiation therapy alone, and radiation lung injury incidence was also lower.
Prognostic nomogram for hepatocellular carcinoma patients after transarterial chemoembolization based on des-γ-carboxy prothrombin reactivity and modified Response Evaluation Criteria in Solid Tumors
Authors: Zhao Su-Ming , Qiu Li-Wei , Zhao Hui , Gu Wei-Wei , Yang Xiao-Hu , Gu Zhu-Xing , Shi Rong-Feng , Ni Cai-Fang 
Published: July 2021

Aims:
The aim of this study was to construct a nomogram that will predict the overall survival (OS) of hepatocellular carcinoma (HCC) patients after transarterial chemoembolization (TACE).

Materials and Methods:
Imaging data, clinical characteristics, and serum des-γ-carboxy prothrombin (DCP) levels of 93 HCC patients treated with TACE were collected. Lasso regression, random forest, and other methods were used to screen the OS-related variables and construct the Cox prognosis model. The model was visualized by nomogram, and the net benefit of the clinical decision was assessed by decision curve analysis (DCA).

Results:
It was found that DCP level after TACE was an important predictor of OS in HCC patients. The OS of the patients with lower serum DCP levels after TACE was significantly better than the group with higher levels (P = 0.003). The Cox prognostic model was constructed using four predictors including DCP reactivity (P = 0.001), modified Response Evaluation Criteria in Solid Tumors (mRECIST, P = 0.005), Child-Pugh class (P = 0.018), and portal vein thrombosis (P = 0.039). The C-index of the nomogram for OS of patients after TACE was 0.813. The clinical decision-making net benefits based on the nomogram were better than the decision-making based on the TNM stage system.

Conclusion:
DCP reactivity and mRECIST are the key predictors of prognosis in HCC patients that received TACE as their initial treatment. The nomogram constructed with these two indicators as the core could predict the OS of HCC patients after TACE and help in clinical decision-making.
Role of Prealbumin in Predicting the Prognosis of Severely and Critically Ill COVID-19 Patients
Authors: Cui Ningning , Tong Haihui , Li Yan , Ge Yanyan , Shi Yuxin , Lv Ping , Zhao Xiaobo , Zhang Jianchu , Fu Gui , Zhou Yanfen , Jiang Ke , Lin Nengxing , Bai Tao , Jin Runming , Wei Sheng , Yang Xuefeng , Li Xin 
Published: July 2021

ABSTRACT.
Most critically ill patients experience malnutrition, resulting in a poor prognosis. This study aimed to evaluate the association of prealbumin (PAB) with the prognosis for severely and critically ill coronavirus disease 2019 (COVID-19) patients and explore factors related to this association. Patients with laboratory-confirmed COVID-19 from West Campus of Union Hospital in Wuhan from January 29, 2020 to March 31, 2020 were enrolled in this study. Patients were classified into the PAB1 (150–400 mg/L; N = 183) and PAB2 (< 150 mg/L; N = 225) groups. Data collection was performed using the hospital’s electronic medical records system. The predictive value of PAB was evaluated by measuring the area under the receiver-operating characteristic (AUROC) curve. Patients were defined as severely or critically ill based on the Guidance for COVID-19 (7th edition) by the National Health Commission of China. During this analysis, 316 patients had severe cases and 65 had critical cases. A reduced PAB level was associated with a higher risk of mortality and a longer hospital stay. The AUROC curve for the prognosis based on the PAB level was 0.93, with sensitivity of 97.2% and specificity of 77.6%. For severe cases, a lower level of PAB was associated with a higher risk of malnutrition, higher NK cell counts, and lower B lymphocyte counts; these factors were not significant in critical cases. C-reactive protein and nutritional status mediated the association between PAB and prognosis. This retrospective analysis suggests that the PAB level on admission is an indicator of the prognosis for COVID-19.
Grade 3 ESL teachers’ (mis)conceptions about vocabulary acquisition, learning and instruction: A case study
Authors: Sibanda Jabulani 
Published: July 2021

development-related (mis)conceptions of ten purposively selected Grade 3 English Second Language teachers in the Eastern Cape province of South Africa, with a view to indexing their vocabulary pedagogical practices. The efficacy of teacher cognition on teaching practices is the theory upon which the present study, which considers vocabulary development as a proxy for literacy attainment, is based. The theory is buttressed by literature on the research-based best practices in literature development against which teachers’ conceptionsare measured. Semi-structured teacher interview findings showed that vocabulary instruction proceeded largely on the basis of intuitive pedagogical decisions which evince dissonance with researchbased best practices. There was a manifest disregard for both incidental andcontextualised vocabulary development, and an apparent underestimation of learners’ potential for independent vocabulary acquisition. Professed instructional strategies only drew learners’ attention to the orthographic and phonological forms of the words at the expense of other crucial dimensions of word knowledge. The paper recommends a consideration of teachers’ vocabulary development-related perceptions as a point of departure for teacher education and teacher professional development, among others.
Association between blood pressure dipping patterns and hypertension-mediated organ damage among Nigerians with newlydiagnosed hypertension
Authors: Dele-Ojo B.F. , Ogunmodede J.A. , Ojo O.D. , Kolo P.M. , Katibi I.A. , Omotoso A.B. , Adeoye M.A. , Adesokan A. 
Published: July 2021

Introduction: Abnormal blood pressure (BP) dipping patterns are associated with increased cardiovascular risk among Africans. This study determined the association between BP dipping patterns and hypertension-mediated organ damage among patients with newly-diagnosed hypertension.Methods: Ambulatory BP monitoring and echocardiography were carried out on 120 participants. Participants were categorized based on the ratio of night-time to day-time systolic BP into 4 patterns: Normal dipper (≥ 10% but < 20%), non-dippers (≥ 0% but < 10%), reverse dippers (<0%) and extreme dippers (≥ 20%).Result: Fifty-one (42.5%) were males, the mean age and body mass index were 44.2±9.8years and 27.1±4.4kg/m2 respectively. The non-dipping pattern was the most prevalent while the reverse dipping had the lowest mitral E/A ratio. Office systolic blood pressure was the only predictor of left ventricular hypertrophy (OR=1.050, 95% CI=1.004-1.098; p-value = 0.034).Conclusions: The non-dipping pattern was the most prevalent abnormal dipping pattern while the reverse dippers had the highest risk of hypertension-mediated organ damage. Office blood pressure was the only predictor of left ventricular hypertrophy. Hence, office BP measurement as well as ambulatory blood pressure measurements are potentially important tools in risk stratification in resource-poor settings of sub-Saharan Africa.
Pregnant women's knowledge, perception and attitudes towards caesarian section among obstetrics unit attendants in a teaching hospital
Authors: Dorkenoo J.E. , Abor P.A. 
Published: July 2021

Background: This study investigated pregnant women's knowledge level, perception and attitudes towards caesarean section in the Obstetrics Unit at the Korle-Bu Teaching Hospital.Methods: We employed a descriptive cross-sectional survey design to conduct the study.Results: The findings of the study revealed that majority (82.2%) of pregnant women have considerable knowledge about conditions that predisposes a woman for caesarean section as well as the risk of complications. Factors which significantly encouraged respondents to undergo caesarean section deliveries were they being necessary to protect the health of their babies (85.8%), having more knowledge about caesarean section procedures and risks and trusting in the competence of the doctor (53%). On the other hand, the study identified some inhibiting factors such as 67% of women perceive that caesarean sections take away the joy of a woman, while giving birth. Respondents (56%) however, indicate that caesarean sections were not unnatural nor only reserved for those with medical issues or those who fear pain; they are not embarrassing to reveal to family, friends, etc.Conclusion: In the case of a tertiary hospital in Ghana, women attending antenatal clinic have acquired adequate knowledge and fairly good attitudes and perceptions about caesarean section, its benefits and possible complications. The findings of this study have important policy and practical implications for other levels hospitals.