bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Cellulose based pH-Sensitive Hydrogel for Highly Efficient Dyes Removal in Water Treatment: Kinetic, Thermodynamic, Theoretical and Computational Studies
Authors: Jabir Loubna , elhammi Hayat , Nor Mohammed , Jilal Issam , Idrissi Abderrahmane El , Amhamdi Hassan , Abou-Salama Mohamed , Ouardi Youssef El , Barkany Soufian El , Laatikainen Katri 
Published: December 2021

Abstract
In this paper, a new green pH-sensitive cellulose based hydrogel (swelling rate ~ 1005 %) was successfully elaborated. However, the new EDTA crosslinked HEC was investigated as adsorbent materiel, which it showed high removal efficiency (~2000 mg.g-1) to aquatic micropollutants, especially methylene blue as cationic dyes model. The synthesis of HEC-EDTA at high advanced crosslinking degree (up to 92 %) that confirmed using structural analyzes (FTIR and 13C CP/MAS-NMR), was cried out using DAEDT and DMAP as acyl transfer agent, where the lamellar morphology (2D- microstructure) was highly suggested basing on the average functionality of the reaction system. The kinetic study showed that the adsorption process was better described by pseudo-second-order kinetic, where the thermodynamic parameters exhibited a negative effect of temperature indicating a physical adsorption process. In addition, the adsorption capacity was studied according to the experimental conditions (pH, contact time, concentration, etc.), and the Freundlich model revealed a strong correlation to the experimental results indicating an energetic heterogeneity of the surface active sites. In the other hand, molecular dynamics (MD) simulations were conducted and optimized using COMPASS II, where the results showed a good agreement with the experiment, and that basing on the intermolecular Non-covalent interaction, molecular structure and cluster configurations.
Construction of an lncRNA–mRNA Co-Expression Regulatory Network Mediating Inflammation and Regeneration Following Acute Pancreatitis Injury
Authors: Wang Jing , Chen Tianjie , Zhang Xiaohua , Zhao Shulei 
Published: December 2021

Abstract
Long noncoding RNAs (lncRNAs) play important roles in the occurrence and development of many diseases and can be used as targets for diagnosis and treatment. However, the expression and function of lncRNAs in the injury and repair of acute pancreatitis (AP) are unclear. To decipher lncRNAs’ regulatory roles in AP, we reanalyzed an RNA-seq dataset of 24 pancreatic tissues, including those of normal control mice (BL), those 7 days after mild AP (D7), and those 14 days after mild AP (D14). The results showed significant differences in lncRNA and mRNA expression of D7/D14 groups compared with the control group. Co-expression analysis showed that differentially expressed (DE) lncRNAs were closely related to immunity- and inflammation-related pathways by trans-regulating mRNA expression. The lncRNA–mRNA network showed that the lncRNAs Dancer, Gmm20488, Terc, Snhg3, and Snhg20 were significantly correlated with AP pathogenesis. WGCNA and cis regulation analysis also showed that AP repair-associated lncRNAs were correlated with extracellular and inflammation-related genes, which affect the repair and regeneration of pancreatic injury after AP. In conclusion, the systemic dysregulation of lncRNAs is strongly involved in remodeling AP’s gene expression regulatory network, and the lncRNA–mRNA expression network could identify targets for AP treatment and damage repair.
Microstructure and Characterization of Ti-Al Explosive Welding Composite Plate
Authors: Bi Zhi-xiong , Li Xue-jiao , Zhang Ting-zhao , Wang Quan , Rong Kai , Dai Xian-de , Wu Yong 
Published: December 2021

Abstract
In order to study the interface characteristics and microstructure formation of Ti-Al composite plate, explosive welding was carried out with TA2 titanium as the fly plate and 5083 aluminums as the base plate. Optical microscope and electron microscope were used to analyze the microstructure of intermetallic compounds. SPH method was used to simulate the welding process of composite plates. The formation conditions and initial defects of intermetallic compounds were analyzed. The results show that most of the melted metal in the wave-front stays in the wave-waist region, and there was a relative velocity difference between the vortex and the titanium tissue, which led to the existence of small pieces of fragmentation. The outer layer of the vortex had higher velocity than the inner layer. The formation of Ti3Al, its antioxidant capacity wound lead to the formation of cracks. The temperature of outer vortex was higher than that of inner vortex, and the vortex has a transition layer of 5 μm, which is thinner than the transition layer of 8 μm between cladding plate and substrate. The jet was mostly composed of aluminum metal, and the interface jet velocity reaches 3000 m·s-1 and the interface temperature reaches up to 2100 K. Compared with the molten metal in the wave-back vortex, the jet temperature at the interface was higher, resulting in a thicker transition layer at the bonding surface. The residual stress at the interface wound cause the density of the material to increase.
Adsorptive Removal of Arsenic by Synthetic Iron-loaded Goethite: Isotherms, Kinetics, and Mechanism
Authors: Talpur Shakeel Ahmed , Baloch Muhammad Yousuf Jat , Su Chunli , Iqbal Javed , Ahmed Aziz 
Published: December 2021

Abstract
Arsenic contamination in the groundwater is a worldwide concern. Therefore, this study was designed to use synthetic iron-loaded goethite to remove arsenic. Adsorption was significantly pH-dependent; hence, pH values between 5.0 and 7.0 resulted in the highest removal of arsenate and arsenite. Langmuir and Freundlich isotherms were almost perfectly matched in terms of strong positive coefficient of determination “R2” arsenate – 0.941 and 0.992 and arsenite – 0.945 and 0.993. The adsorption intensity “n” resulted as arsenate – 2.542 and arsenite – 2.707; besides separation factor “RL” found as arsenate – 0.1 and arsenite – 0.5, respectively. However, both “n” and “RL” leads to a favourable adsorption process. Temkin isotherm yielded in equal binding energies “bt” showing as 0.004 (J/μg) for both arsenate and arsenite. Jovanovic monolayers isotherm was dominated by the Langmuir isotherm. This resulting in maximum adsorption capacity “Qmax” of arsenate – 1369.877 and arsenite – 1276.742 (μg/g), which approaches to the saturated binding sites. Kinetic data revealed that adsorption equilibrium was achieved in 240 – arsenate and 360 – arsenite (minutes), respectively. Chemisorption was found effective with high “R2” values 0.981 ­– arsenate and 0.994 – arsenite, respectively, with the best fitting of pseudo-second order. Moreover, Brunauer Emmett Teller (BET), Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) were used to determine the morphological content, surface area, crystalline structure, and chemical characteristics of the adsorbent. It is anticipated that optimal arsenic removal was achieved by the porosity, chemical bindings, and surface binding sites of the adsorbent.
A Review on Various Analytical Methodologies for Etoricoxib
Authors: Prajapati Malesh , Yamgar Dilip Bhagwan , Desale Mayur Narayan , Fegade Bharti 
Published: December 2021

Etoricoxib belongs to the class of highly selective COX-2 inhibitor NSAIDs. It is mostly used for the treatment of pain, arthritic conditions including rheumatoid arthritis and osteoarthritis. The current study focuses primarily on analytical and bioanalytical method development methodologies, as well as numerous methods established for the estimation of etoricoxib, whether in pharmaceutical dose form or in bulk. Analytical procedures are critical for determining compositions, as they allow us to obtain both qualitative and quantitative results utilising advanced analytical tools. The analytical method for Etoricoxib may be chromatographic, electrochemical, spectral or hyphenated. These methods aid in the comprehension of critical process parameters as well as the minimization of their impact on precision and accuracy. Analytical method development is required to sustain high commercial product quality standards and to meet regulatory requirements. Following the reference, regulatory organisations in several nations have established standards and procedures for providing approval, authentication, and registration. Bioanalytical methods are designed to quantify the concentration of drug, metabolite, or typical biomarkers from various biological fluids including serum, urine, saliva and tissue extracts.
Application of networked water balance model in refined management of steel industrial park
Authors: Wang Yurong , Li Linyuan , He Wentao , Zhang Xinli , Li Xuanjin , Li Xiang , Li Hongying 
Published: December 2021

Abstract
Water shortages have become a major constraint on China's industrial development. Iron and steel industrial parks have a huge demand for water resources and complex production technologies. Therefore, it is very important to study the distribution, transfer and loss of water resources in industrial parks in order to improve the ability to refine water resources management. The purpose of this study was to reveal the water flow in industrial parks by using the principle of water balance and to provide a method for quantification and characteristic recognition of water resources in industrial production processes. In this research, an iron and steel industrial park in North China was chosen as the case study. In order to calculate the water balance of the whole steel production processes, the industrial park was divided into four levels and 110 water units according to the pipe network system and production processes. Based on the results of multi-level and multi-node water balance, this paper analyzed the water intake structure and water consumption structure of industrial parks, and provided the methods to optimize the allocation of water resources and reduce the consumption of fresh water in industrial production processes. The results of the study showed that the energy department accounted for 60.8% of the total water withdrawal of the industrial park. There were 6,249 m3/day of fresh water in the industrial park, which could be replaced by reclaimed water from urban sewage. Evaporation and pipe network leakage were the main water consumption factors in the steel park, which contributed 91.3% of the water consumption. Under the guidance of the research results, the evaporation water consumption of the industrial park was reduced by 8,412 m3/day, and pipe leakage was reduced by 600 m3/day. This article demonstrates the application of the water balance principle in complex water use systems, which is helpful for water resources management based on water use processes.
Nanoparticles Mediated Target-specific Drug Delivery in Prostate
Cancer: An In-depth Review
Authors: Upadhyay Tarun Kumar , Ali Mohammed Irfan , Khan Fahad , Goel Harsh , Mathur Manas , Goyal Keshav , Moin Sarmad , Pandey Pratibha , Tanwar Pranay , Sharangi Amit Baran , Gautam Saloni Dinesh Chandra , Kapdi Jhanvi Kiran , Patel Kruti Indravadan , Patel Meghna Vipulbhai , Parmar Amisha M. , Kamal Mohammad Amjad 
Published: December 2021

:
Nanotechnology has been extensively exploited for its enormous therapeutic
and diagnostic potential in the management of multiple disorders. It employs nanomaterials
as drug carriers with enhanced efficacy and limited side effects on normal tissues. A
lot of nanomaterials have been studied and produced, imminently reforming the treatment
and diagnostics of numerous malignancies, including cancer. The purpose of the
present study is to explore the role of nanotechnology-based devices/therapies that have a
vital function in the therapeutics and diagnostics of cancer with potential impact at three
levels: early detection, tumor imaging, and drug delivery methods. Concentrating on cancer,
promising nanotechnology-based approaches have been planned to satisfy the need
for targeted specificity of traditional agents of chemotherapeutics, in addition to early
recognition of malignant and precancerous lesions. Prostate cancer is the fifth most well--
known cancer worldwide and the second most usually detected cancer in men. Therefore,
there is a crucial need to improve therapeutic prospects for the diagnosis and treatment of
prostate cancer via the exploitation of the potential of nanomaterials for cell-targeted specificity
and improved primary diagnosis of precancerous tumors. The present review,
therefore, focuses on summarizing all prospective applications of nanotechnology in the
prognosis and diagnosis of prostate cancer, which would further help researchers to elucidate
a more potent therapeutic approach for the better management of prostate cancer in
the days ahead.
Withdrawal Notice: Overview of Enzyme Engineering Towards the
Production of Hyaluronic Acid with Tailored Molecular Weight
Authors: Ebrahimi Tahereh , Hosseini Kamran , Ahangari Hossein , Gholizadeh Pourya , Tarhriz Vahideh 
Published: December 2021

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Theracurmin Supplementation May be a Therapeutic Option for Older Patients
with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up
Study
Authors: Dost Fatma Sena , Kaya Derya , Ontan Mehmet Selman , Erken Neziha , Bulut Esra Ateş , Aydin Ali Ekrem , Isik Ahmet Turan 
Published: December 2021

Background:
Alzheimer’s Disease (AD) is still a great global challenge and agents with
various mechanisms represent a promising therapeutic opportunity. Theracurmin, a very highly absorbable
curcumin formulation, was shown to improve memory and attention in non-demented people.

Objective:
The aim of the study was to investigate the effect of Theracurmin on disease course in
elderly patients with mild cognitive impairment (MCI) and AD.

Methods:
This follow-up study was performed retrospectively on 93 patients with MCI or AD. All patients underwent comprehensive geriatric assessment, including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA), clock-drawing test, activities of daily living (ADL), at baseline and end of the 6th-month. 19 patients with AD and 17 with MCI were treated with Theracurmin 180 mg/day per oral.

Results:
MMSE, MOCA and instrumental ADL scores decreased in AD patients not treated with
Theracurmin (p<0.001, p=0.011, and p=0.004, respectively), whereas these scores remained stable
in those treated with Theracurmin. This stabilization in the instrumental ADL was also observed in
MCI patients treated with Theracurmin. During the follow-up, three MCI patients who did not receive
Theracurmin progressed to AD, whereas only one patient progressed in those who received
it.

Conclusion:
Theracurmin seems to be a therapeutic option for elderly patients with AD and MCI
via providing stabilization of the disease course by preventing progressive loss in cognitive functions
and ADLs.
Structure-based De Novo Design and Docking Studies of 5(S)-Methyl-L-Proline
Containing Peptidomimetic Compounds as Dipeptidyl Peptidase-4
Inhibitors
Authors: Pathak Chirag D. , Gajjar Anuradha K. 
Published: December 2021

Background:
Diabetes affects millions of people worldwide, with predicted numbers of
about 700 million adults affected by 2045. Among the several anti-diabetic drug therapies available in
the market, Dipeptidyl Peptidase-4 (DPP-4) inhibitors have emerged as a promising therapeutic approach
with scope for exploration in the segment of peptidomimetics.

Objective:
Series of proline-containing peptidomimetic compounds were designed and investigated for
their drug-likeness through Lipinski’s rule of five, lead-likeness through the rule of three, predictive
pharmacokinetic studies (absorption, distribution, metabolism, and excretion), and toxicity properties
through in-silico approaches. The designed compounds were evaluated for their interactions with
binding sites of the enzyme DPP-4 using an extra precision docking approach.

Methods:
Proline-containing peptidomimetic compounds were designed rationally. Drug-likeness and
lead-likeness properties were calculated using Schrödinger Maestro v11.2 software. ADME and toxicity
properties were predicted using PreADMET version 2.0. Docking study was performed using
Schrödinger Maestro v11.2 software, and ligands for the study were designed using MarvinSketch
software.

Results:
5(S)-methyl-L-proline containing 17 ligands were designed. All of them were found to obey
Lipinski’s rule of five. Compounds were found to have good ADME profile and low toxicity predictions.

Conclusion:
Four compounds were found to have good interactions with DPP-4 binding sites and
hence created the scope to develop DPP-4 inhibitors containing 5(S)-methyl-L-proline moiety.
Investigation of the Experimental Pharmacokinetics of the Bis-Chlorinated Bis-pyridinium Mono-aldoxime Cholinesterase Reactivator K-868 in Rats
Authors: Kalász Huba , Tekes Kornélia , Bátor György , Adeghate Jennifer , Adeghate Ernest , Darvas Ferenc , Fűrész József , Karvaly Gellért 
Published: December 2021

Background:
The widespread use of organophosphorus compounds in agriculture and their existence in some military arsenals present continuous threats. Quaternary bis-pyridinium aldoximes are potent, highly polar cholinesterase reactivators and the most intensively studied candidate antidotes against poisoning with organophosphorus compounds.

Objective:
The in vivo experimental pharmacokinetic properties of K-868, a novel bis-chlorinated, bis-pyridinium mono-aldoxime are detailed and put in context with regard to similar compounds described earlier.

Methods:
Rats received 30 µmol K-868 i.m. and were sacrificed at various time points following treatment. Blood, cerebrospinal fluid and tear were collected, while the brains, eyes, kidneys, livers, lungs and testes were removed, dissected and homogenized. K-868 concentrations were determined using high performance liquid chromatography with ultraviolet absorption detection.

Results:
K-868 was detected in the eyes, kidneys, lungs and tear within 5 minutes in maximal serum concentrations attained 15 minutes following administration. Elimination was slow for K-868 which remained detectable at 120 minutes in the blood and the kidneys, and at 60 minutes in the eyes, lungs and tear following its administration. Nevertheless, its distribution was overall poor with areas under the 120-minute concentration curves (AUC120) showing close similarity in the blood and the kidneys, while reaching just approximately 5% of serum AUC120 in the eyes and lungs.

Conclusion:
K-868 is a potent candidate antidote against organophosphate poisoining with a prolonged presence in the circulation.
Potential Benefits of Tricetin in Medicine for the Treatment of Cancers
and Other Health-Related Disorders: Medicinal Importance and Therapeutic
Benefit
Authors: Patel Dinesh Kumar 
Published: December 2021

Background:
Medicinal plants have been used in medicine for the treatment of numerous
diseases due to their medicinal properties and pharmacological activities. The popularity of herbal-
based drugs in the health sector has been increasing due to patient compliance and cost-effectiveness.
Herbal drugs derived from plant and animal sources have been used in the Ayurvedic,
Homeopathic, and Naturopathic systems of medicine. Medicinal plants have been used as fuel,
clothing, shelter, and food material worldwide since a very early age. Phytoconstituents are pure
plant chemicals found in different parts of the plant material. Flavonoids are an important class of
phytochemicals found in medicinal plants and their derived products.

Methods:
In order to understand the biological significance of tricetin, the present study collected
and analyzed scientific data on tricetin medicinal importance and pharmacological activities.
Literature databases such as Google, PubMed, Science Direct, and Scopus have been searched using
terms tricetin and flavonoid. All the scientific information has been collected from these
databases to know the biological importance of tricetin. Analytical data of tricetin have also been
collected and analyzed in the present work to know the isolation, separation, and identification procedure
of tricetin.

Results:
Scientific data analysis of different research work revealed the presence of tricetin in
Triticum dicoccum, Lathyrus pratensis, Eucalyptus globules, Thuja occidentalis, and Metasequoia
glyptostroboides. Scientific data analysis signified the biological importance of tricetin against different
forms of cancerous disorders, human osteosarcoma, glioblastoma multiforme, human breast
adenocarcinoma, human non-small cell lung cancer, and liver cancer. Scientific data analysis also
signified the biological potential of tricetin against inflammation, neurodegenerative diseases,
atherosclerosis, diabetes, and respiratory syncytial virus infection. Scientific data analysis revealed
the biological importance of tricetin against multidrug resistance and free radicals.

Conclusions:
Scientific data analysis revealed the biological importance and pharmacological activities
of tricetin against various forms of human disorders, including cancer, inflammation, neurodegeneration,
atherosclerosis, and diabetes.