bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Advocacy Coalition Index: A new approach for identifying advocacy coalitions
Authors: Satoh Keiichi , Gronow Antti , Ylä‐Anttila Tuomas 
Published: September 2021

AbstractPolicy scholars have increasingly focused on collaborative and competitive relationships between stakeholder coalitions. The Advocacy Coalition Framework (ACF) in particular has directed scholarly attention toward such relationships. The ACF defines advocacy coalitions as groups of actors who share beliefs and coordinate their action. However, previous research has been inconsistent in defining and measuring coalitions, which has hampered comparative research and theory building. We present a method called the Advocacy Coalition Index, which measures belief similarity and the coordination of action in a manner that makes it possible to assess the extent to which advocacy coalitions are found in policy subsystems, whether subgroups resemble coalitions, and how individual actors contribute to coalition formation. The index provides a standardized method for identifying coalitions that can be applied to comparative research. To illustrate the effectiveness of the index, we analyze two climate change policy subsystems, namely Finland and Sweden, which have been shown to differ in terms of the association of belief similarity with coordination. We demonstrate that the index performs well in identifying the different types of subsystems, coalitions, and actors that contribute the most to coalition formation, as well as those involved in cross‐coalition brokerage.
Opening Pandora's box: molecular phylogeny of the stink bugs (Hemiptera: Heteroptera: Pentatomidae) reveals great incongruences in the current classification
Authors: Roca‐Cusachs Marcos , Schwertner Cristiano F. , Kim Junggon , Eger Joe , Grazia Jocelia , Jung Sunghoon 
Published: September 2021

AbstractPentatomidae is one of the largest families within the Heteroptera and contains many species of economic importance, either by being plant pests or by their usefulness as biological control agents. The family is subdivided into as many as ten subfamilies; however, the monophyly of this taxon and phylogenetic relationships within the family have remained unstudied. In this paper, molecular data from mitochondrial [COI (564 bp), 16S RNA (592 bp)] and nuclear genes [28S RNA (646 bp), 18S RNA (1759 bp)] concatenated into a single matrix of 3589 bp, with a sampling of 160 taxa, were used to test the monophyly of the family and relationships based on Maximum Likelihood (ML) and Bayesian Inference (BI) analyses. Both approaches yielded very similar topologies. The most striking result recovered in both analyses is the rejection of the monophyly of Pentatomidae as currently recognized, since Cyrtocorinae do not show a sister relationship with the clade composed of (Serbana + Pentatomidae sensu stricto) in any of the analyses. We corroborate Serbaninae as the sister lineage to all remaining Pentatomidae sensu stricto, and not as a member of Phloeidae as previously hypothesized. The monophyly of Podopinae and Pentatominae, and some of their respective tribes, is rejected. We discuss the current classification of this family and highlight the necessity of a reinterpretation based on the results herein obtained pointing out some of their morphological features. Additionally, cyrtocorids are defined as an independent lineage and upgraded to Cyrtocoridae stat. rev.
The trans‐SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1‐MMP transport in macrophages
Authors: West Zoe Elizabeth , Aitcheson Savannah Margaret , Semmler Annalese Barbara Trudy , Murray Rachael Zoe 
Published: September 2021

AbstractThe activity of the matrix metalloproteinase (MMP) MT1‐MMP is strictly regulated by expression and cellular location. In macrophages LPS activation leads to the up‐regulation of MT1‐MMP and this need to be at the cell surface for them to degrade the dense extracellular matrix (ECM) components to create a path to migrate into injured and infected tissues. Fixed and live imaging shows newly made MT1‐MMP is packaged into vesicles that traffic to and fuse with LBPA+LAMP1+ late endosomes en route to the surface. The R‐SNARE VAMP4, found on Golgi‐derived vesicles that traffic to late endosomes, forms a trans‐SNARE complex with the Q‐SNARE complex Stx6/Stx7/Vti1b. The Stx6/Stx7/Vti1b complex has been shown to be up‐regulated in lipopolysaccharide (LPS)‐activated cells to increase trafficking of key cytokines through the classical pathway and now we show here it is up‐regulation also plays a role in the late endosomal pathway of MT1‐MMP trafficking. Depletion of any of the SNAREs in this complex reduces surface MT1‐MMP and gelatin degradation. Conversely, overexpression of the Stx6/Stx7/Vti1b components increases surface MT1‐MMP levels. This suggests that Stx6/Stx7/Vti1b is a key Q‐SNARE complex in macrophages during an immune response and in partnership with VAMP4 it regulates transport of newly made MT1‐MMP.
The exports of higher education services from OECD countries to Asian countries: A gravity approach
Authors: Beghin John , Park Byungyul 
Published: September 2021

AbstractWe analyse bilateral exports of higher education services between OECD countries and Asia, using a gravity equation approach, panel data from 1998 to 2016 and PPML regression. The approach treats higher education consumption by Asian countries as a consumable durable good reflecting investment in human capital. Asian students come to OECD countries to obtain degrees from their universities. Structurally, the flow of students from Asian country j to OECD country i depends on the higher education capacity of i, the perceived quality of universities in i, expected earnings in i, a series of bilateral transaction costs between i and j, the income per capita in j, school‐age demographics in j and the usual multilateral trade resistance terms. We find that bilateral flows of students are strongly influenced by wage levels in the host country, bilateral distance, importers’ income, demographics, common language, the visa regime prevailing in bilateral country pairs and the network of migrants from j in i. These results hold through a variation of specifications, proxies and estimation methods. We find mixed evidence on the role of tertiary education capacity in OECD countries and no evidence of a country's university reputations explaining the flow of students. The evolution over time of education capacity, earnings, visa regimes, migrant networks, strong income growth and changes in demographics in nearby export markets explain the emergence of Australia, Canada, Korea and New Zealand and the loss of market share by the US, which still strongly dominates international trade in higher education services. The decline in Chinese students coming to the US is also predicted for the most recent years driven by the reduction in its college‐age population.
Child growth and neurodevelopment after maternal antenatal antibiotic treatment
Authors: Videman Karoliina , Hallamaa Lotta , Heimonen Otto , Mangani Charles , Luntamo Mari , Maleta Kenneth , Ashorn Per , Ashorn Ulla 
Published: September 2021

ObjectiveTo assess whether intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine-pyrimethamine (SP) and azithromycin (AZI) in a malaria-endemic area leads to sustained gains in linear growth and development in their offspring.DesignFollow-up study of a randomised trial.SettingMangochi District in rural southern Malawi.Participants1320 pregnant women and their offspring.InterventionsIPTp monthly with SP and twice with AZI (AZI-SP group), monthly with SP but no AZI (monthly SP), or twice with SP (control). No intervention was given to children.Main outcome measuresCognitive performance using Raven’s Coloured Progressive Matrices (CPM) at 13 years of age; mean height and height-for-age Z-score (HAZ), cumulative incidence and prevalence of stunting (HAZ <−2); weight, body mass index, mid-upper-arm circumference and head circumference.ResultsAt approximately 13 years of age, the mean CPM score was 14.3 (SD 3.8, range 6–29, maximum 36), with no differences between groups. Children in the AZI-SP group were on average 0.4 cm (95% CI −0.9 to 1.7, p=0.6) taller than those in the control group. For cumulative incidence of stunting, the HR in the AZI-SP group was 0.72 (95% CI 0.61 to 0.84, p<0.001) compared with the control and 0.76 (95% CI 0.65 to 0.90, p<0.001) compared with the monthly SP groups. There was no intergroup difference in stunting prevalence or anthropometric measurements.ConclusionsIn rural Malawi, maternal intensified infection control during pregnancy reduces offspring’s cumulative incidence of ever being stunted by 13 years of age. In this study, there was no evidence of a positive impact on cognitive performance.Trial registration numberNCT00131235.
Progression of keratoconus in children and adolescents
Authors: Meyer Jay J , Gokul Akilesh , Vellara Hans R , McGhee Charles N J 
Published: September 2021

AimsTo evaluate the rates of keratoconus progression and associated factors in eyes of children and adolescents.MethodsRetrospective, cohort study of individuals ≤18 years old at the time of keratoconus diagnosis and with at least 6 months of follow-up. Corneal tomography was performed using an Orbscan tomographer (Bausch & Lomb, Rochester, New York, USA) to determine whether progression occurred. Tomographic progression of keratoconus was defined as a change in any of the investigated parameters (keratometry values, KMAX, maximum anterior or posterior elevation, central pachymetry, thinnest pachymetry) beyond the limits of repeatability.Results148 eyes of 106 patients with a mean age of 15.2±2.5 years were studied over a mean follow-up period of 2.9±2.2 years. The overall rate of tomographic progression was 77.0% (114/148 eyes). Eyes that progressed had more advanced disease at presentation with higher anterior curvature (KMAX55.4±6.3 vs 52.2±5.4 dioptres; p<0.01), posterior elevation (108.2±40.9 vs 86.3±35.6 µm; p<0.01) and lower central pachymetry measurements (442.1±56.7 vs 454.4±47.5 µm; p=0.01). Age at presentation, gender, atopy, documented eye rubbing, ethnicity and duration of follow-up were not significantly associated with progression in the multivariate analyses. There was a higher rate of bilateral progression if at least one eye had severe keratoconus (73.9%) compared with no severe keratoconus in either eye (36.8%; p=0.03).ConclusionsA high rate of progression was identified in keratoconic eyes of children and adolescents. More advanced disease at initial presentation may increase the risk of further keratoconus progression.
Incidence, risk factors, natural history and outcomes of heart failure in patients with Graves’ disease
Authors: Naser Jwan A , Pislaru Sorin , Stan Marius N , Lin Grace 
Published: September 2021

ObjectiveGraves’ disease (GD) can both aggravate pre-existing cardiac disease and cause de novo heart failure (HF), but large-scale studies are lacking. We aimed to investigate the incidence, risk factors and outcomes of incident GD-related HF.MethodsPatients with GD (2009–2019) were retrospectively included. HF with reduced ejection fraction (HFrEF) was defined by left ventricular ejection fraction <50% and Framingham criteria, while HF with preserved ejection fraction (HFpEF) was defined according to the HFA-PEFF criteria. HF due to ischaemia, valve disorder or other structural heart disease was excluded. Proportional hazards regression was used to analyse risk factors and outcomes.ResultsOf 1371 patients with GD, HF occurred in 74 (5.4%) patients (31 (2.3%) HFrEF; 43 (3.1%) HFpEF). In HFrEF, atrial fibrillation (AF) (HR 10.5 (3.0–37.3), p<0.001) and thyrotropin receptor antibody (TRAb) level (HR 1.05 (1.01–1.09) per unit, p=0.007) were independent risk factors. In HFpEF, the independent risk factors were chronic obstructive pulmonary disease (HR 7.2 (3.5–14.6), p<0.001), older age (HR 1.5 (1.2–2.0) per 10 years, p=0.001), overt hyperthyroidism (HR 6.4 (1.5–27.1), p=0.01), higher body mass index (BMI) (HR 1.07 (1.03–1.10) per unit, p=0.001) and hypertension (HR 3.1 (1.3–7.2), p=0.008). The risk of cardiovascular hospitalisations was higher in both HFrEF (HR 10.3 (5.5–19.4), p<0.001) and HFpEF (HR 6.7 (3.7–12.2), p<0.001). However, only HFrEF was associated with an increased risk of all-cause mortality (HR 5.17 (1.3–19.9), p=0.02) and ventricular tachycardia/fibrillation (HR 64.3 (15.9–259.7), p<0.001).ConclusionDe novo HF occurs in 5.4% of patients with GD and is associated with increased risk of cardiovascular hospitalisations and mortality. Risk factors include AF, higher TRAb, higher BMI and overt hyperthyroidism.
Investigation of exotic state X(3872) in pp collisions at $$\sqrt{s}=7$$, 13 TeV
Authors: Xu Hong-ge , She Zhi-Lei , Zhou Dai-Mei , Zheng Liang , Kang Xiao-Lin , Chen Gang , Sa Ben-Hao 
Published: September 2021

AbstractWe have used the dynamically constrained phase space coalescence model to study the production of the exotic state X(3872) based on the hadronic final states generated by the parton and hadron cascade model (PACIAE) with $$|y|<1$$

|
y
|
<
1

and $$p_T < 15.5$$

p
T

<
15.5

GeV/c in pp collisions at $$\sqrt{s}=7$$

s

=
7

and 13 TeV, respectively. Here the X(3872) is assumed to consist of bound state $$D\bar{D^*}$$

D

D
∗

¯

, which can form three possible structures for the tetraquark state, the nucleus-like state, and the molecular state. The yields of three different structures X(3872) were predicted. The transverse momentum distribution and the rapidity distribution of three different structures X(3872) are also presented. Sizable difference can be found in the transverse momentum and rapidity distributions for the three different X(3872) structures.
Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas
Authors: Calvo-Vidal M. Nieves , Zamponi Nahuel , Krumsiek Jan , Stockslager Max A. , Revuelta Maria V. , Phillip Jude M. , Marullo Rossella , Tikhonova Ekaterina , Kotlov Nikita , Patel Jayeshkumar , Yang Shao Ning , Yang Lucy , Taldone Tony , Thieblemont Catherine , Leonard John P. , Martin Peter , Inghirami Giorgio , Chiosis Gabriela , Manalis Scott R. , Cerchietti Leandro 
Published: September 2021

Abstract

HSP90 is critical for maintenance of the cellular proteostasis. In cancer cells, HSP90 also becomes a nucleating site for the stabilization of multiprotein complexes including signaling pathways and transcription complexes. Here we described the role of this HSP90 form, referred to as oncogenic HSP90, in the regulation of cytosolic metabolic pathways in proliferating B-cell lymphoma cells. Oncogenic HSP90 assisted in the organization of metabolic enzymes into non-membrane–bound functional compartments. Under experimental conditions that conserved cellular proteostasis, oncogenic HSP90 coordinated and sustained multiple metabolic pathways required for energy production and maintenance of cellular biomass as well as for secretion of extracellular metabolites. Conversely, inhibition of oncogenic HSP90, in absence of apparent client protein degradation, decreased the efficiency of MYC-driven metabolic reprogramming. This study reveals that oncogenic HSP90 supports metabolism in B-cell lymphoma cells and patients with diffuse large B-cell lymphoma, providing a novel mechanism of activity for HSP90 inhibitors.

Significance:
The oncogenic form of HSP90 organizes and maintains functional multienzymatic metabolic hubs in cancer cells, suggesting the potential of repurposing oncogenic HSP90 selective inhibitors to disrupt metabolism in lymphoma cells.
Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma
Authors: Zhai Lijie , Bell April , Ladomersky Erik , Lauing Kristen L. , Bollu Lakshmi , Nguyen Brenda , Genet Matthew , Kim Miri , Chen Peiwen , Mi Xinlei , Wu Jennifer D. , Schipma Matthew J. , Wray Brian , Griffiths John , Unwin Richard D. , Clark Simon J. , Acharya Rajesh , Bao Riyue , Horbinski Craig , Lukas Rimas V. , Schiltz Gary E. , Wainwright Derek A. 
Published: September 2021

Abstract

Purpose:
Glioblastoma (GBM) is an incurable primary brain tumor that has not benefited from immunotherapy to date. More than 90% of GBM expresses the tryptophan (Trp) metabolic enzyme, indoleamine 2,3-dioxygenase 1 (IDO). This observation supported the historical hypothesis that IDO suppresses the antitumor immune response solely through a mechanism that requires intratumoral Trp depletion. However, recent findings led us to investigate the alternative hypothesis that IDO suppresses the anti-GBM immune response independent of its association with Trp metabolism.

Experimental Design:
IDO-deficient GBM cell lines reconstituted with IDO wild-type or IDO enzyme–null cDNA were created and validated in vitro and in vivo. Microarray analysis was conducted to search for genes that IDO regulates, followed by the analysis of human GBM cell lines, patient GBM and plasma, and The Cancer Genome Atlas (TCGA) database. Ex vivo cell coculture assays, syngeneic and humanized mouse GBM models, were used to test the alternative hypothesis.

Results:
Nonenzymic tumor cell IDO activity decreased the survival of experimental animals and increased the expression of complement factor H (CFH) and its isoform, factor H like protein 1 (FHL-1) in human GBM. Tumor cell IDO increased CFH and FHL-1 expression independent of Trp metabolism. Increased intratumoral CFH and FHL-1 levels were associated with poorer survival among patients with glioma. Similar to IDO effects, GBM cell FHL-1 expression increased intratumoral regulatory T cells (Treg) and myeloid-derived suppressor cells while it decreased overall survival in mice with GBM.

Conclusions:
Our study reveals a nonmetabolic IDO-mediated enhancement of CFH expression and provides a new therapeutic target for patients with GBM.
Sex-Related Differences in the Prevalence and Prognostic Value of the Academic Research Consortium for High Bleeding Risk Criteria
Authors: Nardin Matteo , Cao Davide , Mehran Roxana , Chandiramani Rishi , Chiarito Mauro , Sartori Samantha , Qiu Hanbo , Zhang Zhongjie , Golani Ekta , Nicolas Johny , Baber Usman , Dangas George , De Luca Giuseppe , Stefanini Giulio G. , Sweeny Joseph , Sharma Samin K. , Kini Annapoorna 
Published: September 2021

Background:
Bleeding events after percutaneous coronary intervention are associated with substantial morbidity and mortality. Female patients undergoing percutaneous coronary intervention are often older and present with a higher burden of comorbidities, which in turn increases their risk of adverse events, including bleeding complications. The Academic Research Consortium (ARC) have proposed a list of clinical criteria to define high bleeding risk (HBR). Our aim was to evaluate the prevalence and predictive value of the ARC-HBR criteria according to sex in a contemporary cohort of patients undergoing percutaneous coronary intervention.

Methods:
All consecutive patients receiving coronary stenting between 2014 and 2017 at a tertiary-care center were defined as HBR if they fulfilled at least 1 major or 2 minor ARC-HBR criteria. The primary bleeding end point was the composite of periprocedural in-hospital or postdischarge bleeding up to 1 year. Individual components of the primary bleeding end point, all-cause mortality, and myocardial infarction were also evaluated.

Results:

Of the total 9623 patients, 6979 (72.5%) were male and 2644 (27.5%) female. The prevalence of HBR was significantly higher in females compared with males (56.5% versus 39.9%,
P
<0.001). With regard to the individual criteria, moderate/severe anemia and moderate chronic kidney disease were more common in females, while oral anticoagulation and mild anemia were more frequent among males. The presence of HBR was associated with an increased risk of bleeding in both females (10.0% versus 4.4%; hazard ratio, 2.57 [95% CI, 1.80–3.67];
P
<0.001) and males (8.7% versus 2.9%; hazard ratio, 3.19 [95% CI, 2.50–4.08];
P
<0.001)(p
interaction
=0.344). The ARC-HBR criteria associated with the highest bleeding risk at 1 year were severe/end-stage chronic kidney disease and thrombocytopenia in females, and moderate/severe anemia in males.

Conclusions:
In a real-world cohort of percutaneous coronary intervention patients, females were more often at HBR than males. The prognostic value of the ARC-HBR definition was consistent between female and male patients, despite sex-related differences in the prevalence and bleeding risk associated with individual ARC-HBR criteria.
Bleeding and Subsequent Cardiovascular Events and Death in Atrial Fibrillation With Stable Coronary Artery Disease: Insights From the AFIRE Trial
Authors: Kaikita Koichi , Yasuda Satoshi , Akao Masaharu , Ako Junya , Matoba Tetsuya , Nakamura Masato , Miyauchi Katsumi , Hagiwara Nobuhisa , Kimura Kazuo , Hirayama Atsushi , Matsui Kunihiko , Ogawa Hisao ,   on behalf of the AFIRE Investigators
Published: September 2021

Background:
Early bleeding after percutaneous coronary intervention is associated with increased risk of death and myocardial infarction; however, the association between bleeding and subsequent major adverse cardiac and cerebrovascular events (MACCE) remains unclear in patients with atrial fibrillation and stable coronary artery disease. We thus aimed to investigate this association.

Methods:
The AFIRE trial (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) was a multicenter, open-label trial conducted in Japan. This post hoc analysis included 2215 patients with atrial fibrillation and stable coronary artery disease treated with rivaroxaban or rivaroxaban plus an antiplatelet agent. MACCE was defined as a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death from any cause. The association of bleeding with subsequent MACCE risk was investigated using time-adjusted Cox multivariate analysis after adjusting for baseline characteristics and time from bleeding. Bleeding events were classified according to the International Society on Thrombosis and Haemostasis criteria.

Results:

Among the 2215 patients, 386 (17.4%) had bleeding during follow-up, of whom 63 (16.3%) also experienced MACCE; MACCE incidence was higher in patients with bleeding than in those without (8.38% versus 4.20% per patient-year; hazard ratio, 2.01 [95% CI, 1.49–2.70];
P
<0.001). The proportion of patients with both bleeding and MACCE (developed after bleeding) was 73.0% (46 of 63); 27.0% (17 of 63) experienced MACCE before bleeding. Time-adjusted Cox multivariate analysis revealed a temporal association between major bleeding and subsequent MACCE, with particularly high MACCE risks within 30 days after major bleeding (hazard ratio, 7.81 [95% CI, 4.20–14.54]).

Conclusions:
In patients with atrial fibrillation and stable coronary artery disease, major bleeding was strongly associated with subsequent MACCE. Thus, it is important to prevent major bleeding to avoid cardiovascular events and death.

Registration:

URL:
https://www.umin.ac.jp/ctr
; Unique identifier: UMIN000016612. URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02642419.

Graphic Abstract:

A
graphic abstract
is available for this article.