bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike
Authors: Qu Kun , Chen Qiuluan , Ciazynska Katarzyna A. , Liu Banghui , Zhang Xixi , Wang Jingjing , He Yujie , Guan Jiali , He Jun , Liu Tian , Zhang Xiaofei , Carter Andrew P. , Xiong Xiaoli , Briggs John A. G. 
Published: March 2021

AbstractThe spike (S) protein of SARS-CoV-2 has been observed in three distinct pre-fusion conformations: locked, closed and open. Of these, the function of the locked conformation remains poorly understood. Here we engineered a SARS-CoV-2 S protein construct “S-R/x3” to arrest SARS-CoV-2 spikes in the locked conformation by a disulfide bond. Using this construct we determined high-resolution structures confirming that the x3 disulfide bond has the ability to stabilize the otherwise transient locked conformations. Structural analyses reveal that wild-type SARS-CoV-2 spike can adopt two distinct locked-1 and locked-2 conformations. For the D614G spike, based on which all variants of concern were evolved, only the locked-2 conformation was observed. Analysis of the structures suggests that rigidified domain D in the locked conformations interacts with the hinge to domain C and thereby restrains RBD movement. Structural change in domain D correlates with spike conformational change. We propose that the locked-1 and locked-2 conformations of S are present in the acidic high-lipid cellular compartments during virus assembly and egress. In this model, release of the virion into the neutral pH extracellular space would favour transition to the closed or open conformations. The dynamics of this transition can be altered by mutations that modulate domain D structure, as is the case for the D614G mutation, leading to changes in viral fitness. The S-R/x3 construct provides a tool for the further structural and functional characterization of the locked conformations of S, as well as how sequence changes might alter S assembly and regulation of receptor binding domain dynamics.
Designing a memorable in-store customer shopping experience: practical evidence from sports equipment retailers
Authors: Bonfanti Angelo , Yfantidou Georgia 
Published: March 2021

PurposeThis study aims to detect the dimensions of the in-store customer shopping experience from the sports retailer perspective and to investigate how the role of sports equipment stores is changing.Design/methodology/approachThis exploratory study performs semi-structured interviews with retail managers of sports equipment stores.FindingsThis research reveals the importance of the dimensions of immersive design, sensorial ambient elements, social relationships, trialability and real experience sharing in designing a memorable in-store shopping experience in sports stores, and it highlights that the store's role in the sports context is transitioning from sales space to an interactive, immersive, engaging and convivial place. It proposes a model to design the in-store customer shopping experience effectively.Practical implicationsSports equipment managers can make their physical stores as experiential as possible by investing in expert, passionate personnel and technology in order to create a real in-store experience of the product and the sports practice.Originality/valueWhile sports equipment retailers acknowledge the importance of providing customers with a memorable shopping experience by creating an evocative environment and placing multiple touchpoints in stores, management scholars have paid limited attention to sports stores. This study explores the ways in which sports retail managers can design their stores effectively in experiential terms.
Income and factor substitution: an investigation on the Solow growth model under the constant elasticity of substitution
Authors: Alatas Sedat 
Published: March 2021

PurposeThe purpose of this study is to examine whether the elasticity of substitution (ES) varies between developed and developing countries.Design/methodology/approachThe author derives the growth regressions from the Solow model under the constant elasticity of substitution production function by using the first-order Taylor series expansion and estimate them for each country group classified based on time-varying behavior of income per worker using the data-driven algorithm.FindingsThe ES is not unitary and varies among country groups. Developed countries generally have a higher ES than developing countries.Originality/valueFor the first time, the author uses the first-order Taylor series expansion to linearize the steady-state value of income per worker, as the author considers this approach to be relatively more straight-forward and tractable. Furthermore, the author estimates the equations using both cross-section and panel data techniques and employs the data-driven algorithm proposed by Phillips and Sul (2007) to classify countries.
“Post-viral tourism’s antagonistic tourist imaginaries”
Authors: Tzanelli Rodanthi 
Published: March 2021

Purpose
This paper aims to examine the antagonistic coexistence of different tourism imaginaries in global post-viral social landscapes. Such antagonisms may be resolved at the expense of the ethics of tourism mobility, if not adjudicated by post-human reflexivity. Currently, unreflexive behaviours involve the refusal to conform to lifesaving “stay-at-home” policies, the tendency to book holidays and the public inspection of death zones.

Design/methodology/approach
Each of the consumption styles explored in this paper to discuss post-COVID-19 tourism recovery corresponds to at least one tourist imaginary, antagonistically placed against social imaginaries of moral betterment, solidarity, scientific advancement, national security and labour equality. A multi-modal collection of audio-visual and textual data, gathered through social media and the digital press, is categorised and analysed via critical discourse analysis.

Findings
Data in the public domain suggest a split between pessimistic and optimistic attitudes that forge different tourism futures. These attitudes inform different imaginaries with different temporal orientations and consumption styles.

Social implications
COVID-has exposed the limits of the capacity to efficiently address threats to both human and environmental ecosystems. As once popular tourist locales/destinations are turned by COVID-2019s spread into risk zones with morbid biographical records their identities alter and their imaginaries of suffering become anthropocentric.

Originality/value
Using Castoriadis’ differentiation between social and radical imaginaries, Foucault’s biopolitical analysis, Sorokin’s work on mentalities and Sorel’s reflections on violence, the author argue that this paper has entered a new phase in the governance and experience of tourism, which subsumes the idealistic basis of tourist imaginaries as cosmopolitan representational frameworks under the techno-cultural imperatives of risk, individualistic growth through the adventure (“edgework”) and heritage preservation. This paper also needs to reconsider the contribution of technology (not technocracy) to sustainable post-COVID-19 scenarios of tourism recovery.
Influence of service quality on consumer loyalty: a mediation analysis of health insurance
Authors: Abdel Fattah Fadi Abdel Muniem , Dahleez Khalid Abed , Darwazeh Riyad Neman , Al Alawi Abrar Mohammed Mubarak 
Published: March 2021

PurposeThis study aims to examine the influence of service quality (SQ) on customer loyalty (CL) and the mediating role of customer satisfaction (CS) and customer perceived value (CPV) in health insurance products in Malaysia.Design/methodology/approachData were conveniently collected through a self-administered questionnaire from subscribers to health insurance products and services in Malaysia. A total of 456 available questionnaires were used in the analysis. Partial least square (PLS) structural equation modelling (V3.3) was used to obtain the study results.FindingsA positive relationship is observed amongst the studied variables. In addition, CPV partially mediates the proposed relationship and also indirectly mediates the relationship between SQ and CS. Lastly, CS partially mediates the proposed relationship. Hence, all proposed direct and indirect relationships are significant and positive.Research limitations/implicationsThis research increases the authors’ understanding of the role of CS, SQ and CPV on CL in the health insurance industry in a developing country. The study also shows that insurance companies must establish positive relationships between insurers and customers by providing excellent SQ to maintain CS and loyalty.Practical implicationsThis research will help managers and guide the policymakers to establish a national health financing scheme. Furthermore, these results will guide industry players on how to maintain existing and targeting customers.Social implicationsThis study has attempted to provide a comprehensive understanding of CL in the Malaysian health insurance industry. Considering the limited research in the Malaysian health insurance context, this study can provide theoretical contribution and a managerial basis for future studies, including implications for the managers. However, to date, research in this sector under the Malaysian context is not adequate to consider SQ, perceived values and CL factors.Originality/valueThis study has attempted to provide a comprehensive understanding of CL in the Malaysian health insurance industry. Considering the limited research in the Malaysian health insurance context, this study can provide theoretical contribution and a managerial basis for future studies, including implications for the managers.
Re‐engaging in our role with communities: The coupling of occupational therapy and community development
Authors: Irvine‐Brown Laura , Ware Vicki‐Ann , Malfitano Ana Paula Serrata , Di Tommaso Amelia 
Published: March 2021

AbstractIntroductionA growing number of occupational therapists are re‐engaging in work with communities and populations to advance a social justice agenda. To assist in this endeavour, many are coupling occupational therapy and community development theory, as reflected in the social occupational therapy field. Social occupational therapy practitioners work with groups of people who do not necessarily have a health diagnosis or illness but who nonetheless experience occupational issues due to structural barriers within society. Practitioners work across micro‐ and macro‐levels to not only alleviate symptoms of these issues but also to transform their root causes. Although community development is a logical partner to assist such practice, there are inherent tensions in the coupling of these disciplines. This study aimed to explore what theory occupational therapists were using from occupational therapy and community development to guide them in their social occupational therapy practice.MethodsThis study employed a collaborative and participatory qualitative research method. Four occupational therapy community development practitioners each participated in two one‐on‐one dialogical interviews with the first author. These were transcribed and analysed using Braun and Clarke's method of thematic analysis.FindingsFindings were grouped into two themes: (a) Occupational therapy and community development – synergies and tensions, and (b) Of the profession but not in it. Findings highlighted the theoretical shortcomings of occupational therapy for community development practice, theoretical tensions between the two disciplines, and the ‘underground’ nature of occupational therapy community development practice.ConclusionPractitioners should be supported by the occupational therapy profession to be effective community development practitioners, capable of advancing the profession's vision of social justice. Future research should explore methods to support practitioners to navigate tensions between occupational therapy and community development, and bring this practice ‘above ground’.
Masculinities, emotions and men’s suicide
Authors: River Jo , Flood Michael 
Published: March 2021

AbstractMen account for approximately 75% of the one million annual suicide deaths worldwide. Emerging research indicates a link between suicide and men's active pursuit of hegemonic masculinity via emotional restriction. However, little is known of the continuum of suicidal men's emotional practice, and particularly how men mobilise emotions to actively pursue or resist hegemonic masculine ideals. This theorised life‐history study aimed to explore the emotional lives of 18 Australian men who had attempted suicide. Findings indicate that men in this study experienced a range of emotions. However, during childhood, they learned that expressing emotions such as sadness reduced masculine standing, whereas expressing emotions such as anger through acts of violence could enhance masculine status. Although the gendering of emotions offered participants multiple avenues of action to pursue or contest masculine ideals, they remained vulnerable to suicide. For some men, it became impossible to conceal escalating feelings of distress. For other men, displays of anger and violence resulted in job loss, relationship breakdown or criminal conviction. Many participants indicated that suicide presented a means of ending painful emotions. Paradoxically, suicide could also become an alternative means of demonstrating masculinity, whereby the body became both the vehicle and object of violence.
Information, market power, and price volatility
Authors: Bergemann Dirk , Heumann Tibor , Morris Stephen 
Published: March 2021

AbstractWe consider demand function competition with a finite number of agents and private information. We show that any degree of market power can arise in the unique equilibrium under an information structure that is arbitrarily close to complete information. Regardless of the number of agents and the correlation of payoff shocks, market power may be arbitrarily close to zero (the competitive outcome) or arbitrarily large (so there is no trade). By contrast, price volatility is always lower than the variance of the aggregate shock across all information structures. Alternative trading mechanisms lead to very distinct bounds as a comparison with Cournot competition establishes.
The effect of microhabitat features, anthropogenic pressure and spatial structure on bird diversity in southern Tunisian agroecosystems
Authors: Hamza Foued , Hanane Saâd 
Published: March 2021

AbstractIn southern Tunisia, oases and olive orchards are the two main agroecosystems, hence the importance of investigating their value for native fauna. Using generalised linear mixed models, we assessed the relative value of oases and olive plantations over the wintering and the breeding periods by comparing their avifauna diversity using the Shannon diversity index. We also used data on a series of microhabitat features, anthropogenic pressure and spatial parameters to identify the best predictors of bird diversity. In total, 32 species belonging to 18 families were recorded. Sedentary birds accounted for 47% of the counts. Our results showed that bird diversity depends on habitat type, being higher in oases than in olive plantations, but not on the season as no difference was recorded during the two periods of wintering and breeding. The assessment of the effects of microhabitat features, anthropogenic pressure and spatial structure revealed that bird diversity was positively influenced by the cover of trees in oases and olive orchards, negatively affected by distance to edge and that to the paved road in the olive orchards and spatially structured in both agroecosystems. Variation partitioning analysis revealed that the pure effect of microhabitat features (tree cover) was important in explaining the bird diversity both in oases and olive orchards. The identification of factors affecting bird diversity is of great importance for the efficient management of these agroecosystems. Special attention should be paid to keeping a good tree cover. This cannot be performed without: (a) increasing irrigation frequency, (b) adequate tree maintenance (pruning) and (c) reduction of pesticide application. Also, the synergy among owners, farmers, managers and researchers is recommended for the conservation of bird diversity in this North African arid agricultural region.
The COVID‐19 pandemic: shocks to human capital and policy responses
Authors: Deng Guichuan , Shi Jing , Li Yanli , Liao Yin 
Published: March 2021

AbstractThe COVID‐19 pandemic is significantly disrupting human capital in labour markets. Workforce reductions cause firm outputs to fall and prices to rise, leading to unprecedented economic costs. To quantify the economic costs, we develop a dynamic general equilibrium macroeconomic model that incorporates susceptible–infectious–recovered epidemiology dynamics, where individuals can be healthy, infected or recovered so that evolution of human capital can be well tracked. We characterise optimal public policy responses to the decline in human capital by either isolating susceptible residents from infected residents to reduce the spread of disease or increases in government spending to improve the recovery and death rates.
Cognitive boosting interventions for impulsivity in addiction: a systematic review and meta‐analysis of cognitive training, remediation and pharmacological enhancement
Authors: Anderson Alexandra C. , Youssef George J. , Robinson Alex H. , Lubman Dan I. , Verdejo‐Garcia Antonio 
Published: March 2021

AbstractAimsTo evaluate and compare the effects of three cognitive boosting intervention approaches (computerised cognitive training, cognitive remediation and pharmacological cognitive enhancers) on measures of impulsive action and impulsive choice.DesignSystematic review and meta‐analysis of publications that reported original controlled trials of cognitive boosting interventions.SettingStudies conducted anywhere in the world. No language restrictions were applied.ParticipantsTreatment‐seeking adults with substance use disorder or gambling disorder.MeasurementsOur primary outcome was a reduction in impulsive action or choice on a validated cognitive measure post‐intervention. We assessed risk of bias using the Cochrane Collaboration tool and determined pooled estimates from published reports. We performed random‐effects analyses for impulsive action and impulsive choice outcomes and planned moderator analyses.FindingsOf 2204 unique studies identified, 60 were included in the full‐text review. Twenty‐three articles were considered eligible for inclusion in the qualitative synthesis and 16 articles were included in our meta‐analysis. Articles eligible for pooled analyses included five working memory training (computerised cognitive training) studies with 236 participants, three goal management training (cognitive remediation) studies with 99 participants, four modafinil (cognitive enhancer) studies with 160 participants and four galantamine (cognitive enhancer) studies with 131 participants. Study duration ranged from 5 days to 13 weeks, with immediate follow‐up assessments. There were no studies identified that specifically targeted gambling disorder. We only found evidence for a benefit on impulsive choice of goal management training, although only in two studies involving 66 participants (standardised mean difference (SMD) = 0.86; 95% CI = 0.49–1.23; P = 0.02; I2 = 0%, P = 0.95).ConclusionCognitive remediation, and specifically goal management training, may be an effective treatment for addressing impulsive choice in addiction. Preliminary evidence does not support the use of computerised cognitive training or pharmacological enhancers to boost impulse control in addiction.
Outcome of early‐onset fetal growth restriction with or without abnormal umbilical artery Doppler flow
Authors: Gairabekova Diana , van Rosmalen Joost , Duvekot Johannes J. 
Published: March 2021

ABSTRACTIntroductionEarly‐onset fetal growth restriction is a pregnancy complication often coinciding with abnormal Doppler flow in the umbilical artery. Absent or reversed end‐diastolic flow in the umbilical artery is associated with adverse perinatal outcome. As the optimal management of this condition is unclear, the objective of this study was to analyze the time interval from admission to delivery of pregnancies with early‐onset fetal growth restriction, while pursuing a policy of postponing delivery unless active management of labor would be required because of fetal distress or maternal condition. We also assessed short‐ and long‐term perinatal outcome.Material and methodsIn this historical cohort study, all pregnant women with singleton pregnancies, admitted during 2004–2015 with early‐onset fetal growth restriction were included. Pregnancies with absent or reversed end‐diastolic flow (AREDF) were compared with pregnancies with a positive end‐diastolic Doppler flow (PEDF). Time until delivery was determined and perinatal outcome was assessed for both groups.ResultsIn our study, 111 women were allocated to the PEDF group and 109 to the AREDF group. In the AREDF group, fetal distress was more often an indication for delivery, in comparison with the PEDF group (p = .004). Median time until delivery in patients admitted between 26 and 28 weeks’ gestation was 6+5 weeks in the PEDF group and 1+4 weeks in the AREDF group (p = .001). No statistically significant difference was found between the Doppler groups in the composite adverse neonatal outcome, which includes at least one of the following outcomes: infant respiratory distress syndrome, sepsis, bronchopulmonary dysplasia, necrotizing enterocolitis, intraventricular hemorrhage >grade 2, periventricular leukomalacia and perinatal death (p = .63).ConclusionsIn this study, comprising pregnancies with early‐onset fetal growth restriction, fetal distress was observed more frequently in the AREDF group with the consequence of delivery at an earlier stage of gestation, compared with the PEDF group. AREDF was not associated with increased perinatal morbidity and mortality compared with PEDF.
Pathogens associated with pleuritic pig lungs at an abattoir in Queensland Australia
Authors: Turni C , Meers J , Parke K , Singh R , Yee S , Templeton J , Mone NK , Blackall PJ , Barnes TS 
Published: March 2021

ObjectivePleurisy in pigs has economic impacts in the production stage and at slaughter. This study sought to establish if some micro‐organisms can be found in high numbers in lungs with pleurisy by assessing batches of pigs at an abattoir in Queensland Australia.DesignSamples of lung (including trachea/bronchus and lymph nodes) from a maximum of 5 pleurisy affected pigs were collected from 46 batches of pigs representing 46 Queensland farms.ProcedurePleurisy‐affected lung areas were cultured by traditional bacteriological methods and bacteria quantified by plate scores. Additionally, tracheal or bronchial swabs and apical lobe fluid were tested forMycoplasma hyopneumoniaeDNA and the superior tracheobronchial lymph nodes were tested for porcine circovirus type 2 DNA by polymerase chain reaction (PCR). All apparently significant bacteria were identified via PCR or sequencing. Typing was undertaken on some of the bacterial isolates.ResultsThe most prevalent pathogens wereM. hyopneumoniae,Streptococcus suisand Porcine Circovirus type 2, being found in 34, 38 and 31 batches, respectively. Other bacteria found wereActinobacillusspecies (29 batches),Pasteurella multocida(24 batches),Mycoplasma flocculare(9 batches),Actinobacillus pleuropneumoniae(7 batches),Mycoplasma hyorhinis(4 batches), Bisgaard Taxon 10 (1 batch),Glaesserella parasuis(1 batch),Streptococcus minor(1 batch) andStreptococcus porcinus(1 batch). Most batches had more than one bacterial species.ConclusionThe high percentage of batches infected withS. suis(83%),M. hyopneumoniae(74%) and PCV2 (70%) and clustering by a batch of these pathogens, as well as the presence of many secondary pathogens, suggests synergy between these organisms may have resulted in pleurisy.