bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pause in time: history writers and the regicide of Charles I
Authors: Wong Matthias Meng Yan 
Published: July 2021

Abstract
The unprecedented trial and execution of Charles I left a nation aghast and bewildered. This article examines how the English reacted to such a disruptive event, namely how the regicide changed ideas of time and the future. Using a diachronic approach, this article examines the work of three history writers and the temporalities embedded within their narratives. Recognizing the significance of the regicide as a singular moment in time, these writers adapted their work to incorporate a sense of changed times. By envisioning futures in their texts, these histories informed but also circumscribed the world views of their readers.
Common variants in SCN10A gene associated with Brugada syndrome
Authors: Huang Yan , Chen Xiao-Meng , Barajas-Martinez Hector , Jiang Hong , Antzelevitch Charles , Hu Dan 
Published: July 2021

Abstract
Genome-wide association studies indicate that SCN10A plays an important role in cardiac electrophysiology. Common and rare SCN10A variants are suggested to contribute to Brugada Syndrome (BrS), an inherited channelopathy resulting from genetic-determined loss-of-function in cardiac sodium channel. This study sought to characterize the role of SCN10A common variants in BrS. Clinical and genetic analyses were performed in 197 patients diagnosed with BrS. Baseline ECG parameters were evaluated in patients carrying each of four common variants associated with BrS. Cellular electrophysiological study was performed in SCN5A-SCN10A co-transfected TSA201 cells to investigate the possible electrophysiological characteristics of the allele of rs6795970, which displayed the most significant association with BrS. Four SCN10A common variants (rs7630989, rs57326399, rs6795970, rs12632942) displayed significant association with BrS susceptibility. There were no evident associations between baseline ECG parameters in BrS patients and the different genotypes of the four variants. Rs6795970 (V1073) was strongly associated with a risk for BrS, which suggests the different electrophysiological characters between these two alleles. Functional study showed a positive shift in steady-state activation (V1/2: −62.2 ± 2.6 vs. –53.5 ± 1.6 for A1073 and V1073 group, respectively; P &lt; 0.05) and slower recovery from inactivation in mutant SCN5A-SCN10A co-transfected cells with, which contribute to the slow conduction in BrS patients with rs6795970. In conclusion, SCN10A common variants are associated with increased susceptibility to BrS. An allele rs6795970 (V1073) increases the risk for BrS. The electrophysiological changes in a positive shift in steady-state activation and slower recovery from inactivation by SCN10A-V1073 contribute to this variant associated BrS.
A Framework for Investigating Rules of Life by Establishing Zones of Influence
Authors: Lawing A Michelle , McCoy Michael , Reinke Beth A , Sarkar Susanta K , Smith Felisa A , Wright Derek 
Published: July 2021

SynopsisThe incredible complexity of biological processes across temporal and spatial scales hampers defining common underlying mechanisms driving the patterns of life. However, recent advances in sequencing, big data analysis, machine learning, and molecular dynamics simulation have renewed the hope and urgency of finding potential hidden rules of life. There currently exists no framework to develop such synoptic investigations. Some efforts aim to identify unifying rules of life across hierarchical levels of time, space, and biological organization, but not all phenomena occur across all the levels of these hierarchies. Instead of identifying the same parameters and rules across levels, we posit that each level of a temporal and spatial scale and each level of biological organization has unique parameters and rules that may or may not predict outcomes in neighboring levels. We define this neighborhood, or the set of levels, across which a rule functions as the zone of influence. Here, we introduce the zone of influence framework and explain using three examples: (a) randomness in biology, where we use a Poisson process to describe processes from protein dynamics to DNA mutations to gene expressions, (b) island biogeography, and (c) animal coloration. The zone of influence framework may enable researchers to identify which levels are worth investigating for a particular phenomenon and reframe the narrative of searching for a unifying rule of life to the investigation of how, when, and where various rules of life operate.
Surgical glue-induced left main trunk stenosis removed by directional coronary atherectomy
Authors: Kitamura Hideki , Tamaki Mototsugu , Kawaguchi Yasuhiko 
Published: July 2021

AbstractA 55-year-old man underwent aortic repair for acute aortic dissection. The pseudolumen of the Valsalva sinus was reapproximated with BioGlue by placing a sponge inside of it to prevent the BioGlue from entering. Postoperative contrast-enhanced computed tomography showed stenosis of the left main trunk. Directional coronary atherectomy was performed; complete release of the stenosis was achieved. Various fragments retrieved from the left main trunk were pathologically consistent with BioGlue. When we reapproximated the dissected aortic wall, inserting a sponge into the aorta did not prevent the surgical glue from entering. Directional coronary atherectomy was a good therapeutic option to treat glue-induced coronary artery stenosis.
A review of modeling of luminescent coupling effect in multi-junction solar cell based on diode equation
Authors: Liu Zhezhi , Lv Hui , Hu Yue , Liao Jun , Zhou Hang , Su Yuehong 
Published: July 2021

Abstract
The luminescent coupling effect in multi-junction solar cell is a phenomenon where extra photocurrent in one sub-cell is driven by radiative recombination of electron–hole pairs in another sub-cell. This paper focuses on the analysis of the modeling of luminescent coupling effect in multi-junction solar cell. These modelings are based on the two-diode equivalent circuit. Finally, it concludes that the study of the luminescent coupling effect requires not only a suitable modeling but also a good experimental method for detecting the characteristics of sub-cells in multi-junction solar cell.
Tear film dynamics with blinking and contact lens motion
Authors: Anderson Daniel M , Corsaro Maria , Horton Jonathan , Reid Tim , Seshaiyer Padmanabhan 
Published: July 2021

Abstract
We develop a lubrication theory-based mathematical model that describes the dynamics of a tear film during blinking and contact lens (CL) wear. The model extends previous work on pre-corneal tear film dynamics during blinking by coupling the partial differential equation for tear film thickness to a dynamic model for CL motion. We explore different models for eyelid motion and also account for possible voluntary and involuntary globe (eyeball) rotation that may accompany blinking. Boundary conditions for mass flux at the eyelids are also adapted to account for the presence and motion of the CL. Our predictions for CL motion compare reasonably with existing data. Away from the eyelids the pre-lens tear film (PrLTF) is shifted, relative to its pre-corneal counterpart, in the direction of CL motion. Near the eyelids, the inflow/outflow of fluid under the eyelids also influences the PrLTF profile. We also compare our PrLTF dynamics to existing in vivo tear film thickness measurements.
Predicting brain function status changes in critically ill patients via Machine learning
Authors: Yan Chao , Gao Cheng , Zhang Ziqi , Chen Wencong , Malin Bradley A , Ely E Wesley , Patel Mayur B , Chen You 
Published: July 2021

Abstract

Objective
In intensive care units (ICUs), a patient’s brain function status can shift from a state of acute brain dysfunction (ABD) to one that is ABD-free and vice versa, which is challenging to forecast and, in turn, hampers the allocation of hospital resources. We aim to develop a machine learning model to predict next-day brain function status changes.

Materials and Methods
Using multicenter prospective adult cohorts involving medical and surgical ICU patients from 2 civilian and 3 Veteran Affairs hospitals, we trained and externally validated a light gradient boosting machine to predict brain function status changes. We compared the performances of the boosting model against state-of-the-art models—an ABD predictive model and its variants. We applied Shapley additive explanations to identify influential factors to develop a compact model.

Results
There were 1026 critically ill patients without evidence of prior major dementia, or structural brain diseases, from whom 12 295 daily transitions (ABD: 5847 days; ABD-free: 6448 days) were observed. The boosting model achieved an area under the receiver-operating characteristic curve (AUROC) of 0.824 (95% confidence interval [CI], 0.821-0.827), compared with the state-of-the-art models of 0.697 (95% CI, 0.693-0.701) with P &lt; .001. Using 13 identified top influential factors, the compact model achieved 99.4% of the boosting model on AUROC. The boosting and the compact models demonstrated high generalizability in external validation by achieving an AUROC of 0.812 (95% CI, 0.812-0.813).

Conclusion
The inputs of the compact model are based on several simple questions that clinicians can quickly answer in practice, which demonstrates the model has direct prospective deployment potential into clinical practice, aiding in critical hospital resource allocation.
Community development with externalities and corrective taxation
Authors: Barseghyan Levon , Coate Stephen 
Published: July 2021

Abstract
This paper studies the impact of granting a community the authority to tax development when growth imposes negative externalities on existing residents. Taxes are chosen in each period by the residents who are fully forward-looking. Residents’ policy choices reflect not only the desire to counter negative externalities but also their wish to raise tax revenues and the value of their homes. There exists an equilibrium in which taxes are gradually lowered to close to optimal levels, resulting in falling housing prices and increasing community size. In addition, there exist equilibria in which taxes are set much too high and development is permanently stalled. In these equilibria, residents anticipate that lowering taxes will cause a sharp fall in the value of their homes. This multiplicity of equilibrium means that, for a broad range of initial conditions, allowing residents to tax development can increase or decrease social welfare. Regulating growth with zoning generates even worse outcomes, but allowing the community to charge developers impact fees does better.
Cross-Sectional Associations among Components of Injustice Appraisals and Functioning in Adolescents With Chronic Pain
Authors: Lynch Milder Mary K , Miller Megan M , Williams Amy E , Michel Martha A , Tolley James , Scott Eric L , Hirsh Adam T 
Published: July 2021

Abstract

Objective
Pain-related appraisals, including pain-related injustice, impact the development and maintenance of chronic pain. This cross-sectional study aimed to examine the relationship between the cognitive-emotional components of pain-related injustice—blame/unfairness and severity/irreparability of loss—and functioning in a mixed sample of adolescents with chronic pain.

Methods
Pediatric patients age 11–18 years (N = 408) completed forms assessing pain-related injustice, pain intensity, and physical and psychosocial functioning as part of their routine assessment in a pediatric chronic pain clinic between January 2014 and January 2019. A series of hierarchical regressions were used to evaluate the relationships among the separate components of pain-related injustice appraisals and functioning.

Results
Pain intensity and blame/unfairness appraisals were significantly associated with emotional functioning with blame/unfairness being the stronger association (β = −.27). Blame/unfairness appraisals, severity/irreparability appraisals, and pain intensity were significantly associated with physical functioning with pain intensity being the strongest association (β = .36). Pain intensity, blame/unfairness appraisals, and severity/irreparability appraisals were significantly associated with social functioning with blame/unfairness being the strongest association (β = −.34). Pain intensity and severity/irreparability appraisals were significantly associated with school functioning with severity/irreparability being the stronger association (β = −.19).

Conclusions
These results lend further support to incorporating pain-related injustice appraisals in standard clinical pain assessments. Treatment practices should target the specific injustice appraisals and domains of functioning impacted for each pediatric patient with chronic pain.
Digital clubbing as first sign of giant solitary fibrous tumor. A case report
Authors: Mejías-Lafontaine Emanuel , Galarza Sandra , Gonzalez-Cancel Ivan 
Published: July 2021

Abstract
Solitary fibrous tumors are rare pleural tumors. Most of the time they are benign tumors and identified incidentally once they cause symptoms secondary to their mass effect. Here we present an interesting case of a 54-year-old female found with a giant solitary fibrous tumor with signs of hypertrophic pulmonary osteoarthropathy with associated digital clubbing 6 month before identifying the tumor. The initial percutaneous biopsy revealed pathologic findings consistent with benign solitary fibrous tumor, but after complete mass excision diagnosis was upgraded to a malignant solitary fibrous tumor. Percutaneous biopsy results should not guide therapy in these patients; this is why complete excision continues to be the treatment of choice.
‘Spikelet stop’ determines the maximum yield potential stage in barley
Authors: Thirulogachandar Venkatasubbu , Schnurbusch Thorsten 
Published: July 2021

Abstract
Determining the grain yield potential contributed by grain number is a step towards advancing the yield of cereal crops. To achieve this aim, it is pivotal to recognize the maximum yield potential (MYP) of the crop. In barley (Hordeum vulgare L.), the MYP is defined as the maximum spikelet primordia number of a spike. Many barley studies assumed the awn primordium (AP) stage to be the MYP stage regardless of genotypes and growth conditions. From our spikelet-tracking experiments using the two-rowed cultivar Bowman, we found that the MYP stage can be different from the AP stage. Importantly, we find that the occurrence of inflorescence meristem deformation and its loss of activity coincided with the MYP stage, indicating the end of further spikelet initiation. Thus, we recommend validating the barley MYP stage with the shape of the inflorescence meristem and propose this approach (named ‘spikelet stop’) for MYP staging. To clarify the relevance of AP and MYP stages, we compared the MYP stage and the MYP in 27 barley accessions (two- and six-rowed accessions) grown in the greenhouse and in the field. Our results reveal that the MYP stage can be reached at various developmental stages, which greatly depend on the genotype and growth conditions. Furthermore, we propose that the MYP stage and the time to reach the MYP stage can be used to determine yield potential in barley. Based on our findings, we suggest key steps for the identification of the MYP stage in barley that may also be applied in a related crop such as wheat.
Morphometric relationships and their contribution to biomass and cannabinoid yield in hybrids of hemp (Cannabis sativa)
Authors: Carlson Craig H , Stack George M , Jiang Yu , Taşkıran Bircan , Cala Ali R , Toth Jacob A , Philippe Glenn , Rose Jocelyn K C , Smart Christine D , Smart Lawrence B 
Published: July 2021

Abstract
The breeding of hybrid cultivars of hemp (Cannabis sativa L.) is not well described, especially the segregation and inheritance of traits that are important for yield. A total of 23 families were produced from genetically diverse parents to investigate the inheritance of morphological traits and their association with biomass accumulation and cannabinoid yield. In addition, a novel classification method for canopy architecture was developed. The strong linear relationship between wet and dry biomass provided an accurate estimate of final dry stripped floral biomass. Of all field and aerial measurements, basal stem diameter was determined to be the single best selection criterion for final dry stripped floral biomass yield. Along with stem diameter, canopy architecture and stem growth predictors described the majority of the explainable variation of biomass yield. Within-family variance for morphological and cannabinoid measurements reflected the heterozygosity of the parents. While selfed populations suffered from inbreeding depression, hybrid development in hemp will require at least one inbred parent to achieve uniform growth and biomass yield. Nevertheless, floral phenology remains a confounding factor in selection because of its underlying influence on biomass production, highlighting the need to understand the genetic basis for flowering time in the breeding of uniform cultivars.
Does Chance Undermine Would?
Authors: Kocurek Alexander W 
Published: July 2021

AbstractCounterfactual scepticism holds that most ordinary counterfactuals are false. The main argument for this view appeals to a ‘chance undermines would’ principle: if ψ would have some chance of not obtaining had ϕ obtained, then ϕ □→ ψ is false. This principle seems to follow from two fairly weak principles, namely, that ‘chance ensures could’ and that ϕ □→ ψ and ϕ ⋄→ ¬ ψ clash. Despite their initial plausibility, I show that these principles are independently problematic: given some modest closure principles, they entail absurdities. Moreover, on the most promising strategy for saving these principles, they do not, in the relevant sense, entail the chance-undermines-would principle. Instead, they entail a principle that only supports counterfactual indeterminism, the view that most ordinary counterfactuals are chancy, that is, not settled true. I demonstrate this by developing an indeterminist semantics that vindicates the clash and chance-ensures-could principles but not the chance-undermines-would principle. This view, I argue, offers a better account of our credal and linguistic judgements than counterfactual scepticism.
Discovery of orbital eccentricity and evidence for orbital period increase of SS433
Authors: Cherepashchuk A M , Belinski A A , Dodin A V , Postnov K A 
Published: July 2021

ABSTRACT
The examination of long-term (1979–2020) photometric observations of SS433 enabled us to discover a non-zero orbital eccentricity of e = 0.05 ± 0.01. We have also found evidence for a secular increase in the orbital period at a rate of $\dot{P}_\mathrm{b}=(1.0\pm 0.3)\times 10^{-7}$ s s−1. The binary orbital period increase rate makes it possible to improve the estimate of the binary mass ratio q = MX/MV &gt; 0.8, where MX and MV are the masses of the relativistic object and the optical star, respectively. For an optical star mass of 10 M⊙, the mass of the relativistic object (a black hole) is MX &gt; 8 M⊙. A neutron star in SS433 is reliably excluded because in that case the orbital period should decrease, in contradiction to observations. The derived value of $\dot{P}_\mathrm{b}$ sets a lower limit on the mass-loss rate in the Jeans mode from the binary system ≳7 × 10−6 M⊙ yr−1. The discovered orbital ellipticity of SS433 is consistent with the model of the slaved accretion disc tracing the precession of the misaligned optical star’s rotational axis.
Trauma-Informed Care in Music Therapy: Principles, Guidelines, and a Clinical Case Illustration
Authors: Heiderscheit Annie , Murphy Kathleen M 
Published: July 2021

Abstract
The 2019 National Survey on Drug Use and Health reports that 9.5 million Americans aged 18 and older have been diagnosed with more than one mental disorder. Music therapists working in mental health treatment settings are likely to work with individuals who have a complex diagnosis defined here as 2 or more of the following: depression, eating disorder, generalized anxiety disorder, substance use disorder, and severe mental illness. Additionally, adverse childhood events or posttraumatic stress disorder often complicate the clinical profile. Given this, a trauma-informed approach to music therapy treatment is necessary to improve outcomes and minimize harm. The risks, contraindications, and ethical considerations necessary to effectively treat and care for these clients in music therapy will be reviewed. Methods of identifying, assessing, and treating these complex clinical issues in music therapy are discussed with the goal of helping clinicians understand: (1) where treatment needs to begin to ensure therapeutic goals addressing primary issues prior to addressing secondary issues and (2) the appropriate use of music therapy methods. The necessity for music therapists to understand the power of the music in the music therapy process is explored, to ensure that clinicians are meeting client needs, not triggering symptomatology, traumatic memories, or experiences. The importance of a clinician knowing their scope of practice, when they are adequately trained and prepared to work with clients with complex disorders, and how to utilize support such as consultation and supervision to support their effective treatment with client(s) is presented.
Pyrophosphate release acts as a kinetic checkpoint during high-fidelity DNA replication by the Staphylococcus aureus replicative polymerase PolC
Authors: Fagan Sean P , Mukherjee Purba , Jaremko William J , Nelson-Rigg Rachel , Wilson Ryan C , Dangerfield Tyler L , Johnson Kenneth A , Lahiri Indrajit , Pata Janice D 
Published: July 2021

Abstract
Bacterial replication is a fast and accurate process, with the bulk of genome duplication being catalyzed by the α subunit of DNA polymerase III within the bacterial replisome. Structural and biochemical studies have elucidated the overall properties of these polymerases, including how they interact with other components of the replisome, but have only begun to define the enzymatic mechanism of nucleotide incorporation. Using transient-state methods, we have determined the kinetic mechanism of accurate replication by PolC, the replicative polymerase from the Gram-positive pathogen Staphylococcus aureus. Remarkably, PolC can recognize the presence of the next correct nucleotide prior to completing the addition of the current nucleotide. By modulating the rate of pyrophosphate byproduct release, PolC can tune the speed of DNA synthesis in response to the concentration of the next incoming nucleotide. The kinetic mechanism described here would allow PolC to perform high fidelity replication in response to diverse cellular environments.
The clinical importance of tandem exon duplication-derived substitutions
Authors: Martinez Gomez Laura , Pozo Fernando , Walsh Thomas A , Abascal Federico , Tress Michael L 
Published: July 2021

Abstract
Most coding genes in the human genome are annotated with multiple alternative transcripts. However, clear evidence for the functional relevance of the protein isoforms produced by these alternative transcripts is often hard to find. Alternative isoforms generated from tandem exon duplication-derived substitutions are an exception. These splice events are rare, but have important functional consequences. Here, we have catalogued the 236 tandem exon duplication-derived substitutions annotated in the GENCODE human reference set. We find that more than 90% of the events have a last common ancestor in teleost fish, so are at least 425 million years old, and twenty-one can be traced back to the Bilateria clade. Alternative isoforms generated from tandem exon duplication-derived substitutions also have significantly more clinical impact than other alternative isoforms. Tandem exon duplication-derived substitutions have &gt;25 times as many pathogenic and likely pathogenic mutations as other alternative events. Tandem exon duplication-derived substitutions appear to have vital functional roles in the cell and may have played a prominent part in metazoan evolution.