bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food in a colonial setting: the flora assemblage of a short-lived Seleucid-founded site in the Near East
Authors: Orendi Andrea , Lichtenberger Achim , Tal Oren 
Published: January 2021

AbstractIn this paper we present the analysis of archaeobotanical material retrieved by means of flotation from well-secured features during recent excavation work carried out in 2019 and 2020 by the German-Israeli Tell Iẓṭabba Excavation Project in the Seleucid-founded town of Nysa-Scythopolis. Founded under Antiochus IV Epiphanes (175–164 bce) and destroyed by the Hasmonaeans in the later years of John Hyrcanus (in 108/07 bce), the site offers a unique opportunity for observing the dietary habits of its settlers. The large sample size, namely the largest well-secured Seleucid assemblage ever analyzed in the southern Levant, together with its versatile provenance exhibit previously unknown information for the Hellenistic southern Levant vis-à-vis a unique case-study of high resolution systematic archaeobotanical analysis. The botanical assemblage from Tell Iẓṭabba gives a clearer picture of botanical dietary practices in Hellenistic Palestine. By presenting the archaeobotanical data of the published Hellenistic assemblages from the southern Levant, we offer a comprehensive overview of the agrarian resources cultivated and consumed as food at the time and period.
Congenital abdominal wall defects and cryptorchidism: a population-based study
Authors: Raitio Arimatias , Syvänen Johanna , Tauriainen Asta , Hyvärinen Anna , Sankilampi Ulla , Gissler Mika , Helenius Ilkka 
Published: January 2021

AbstractPurposeSeveral studies have reported high prevalence of undescended testis (UDT) among boys with congenital abdominal wall defects (AWD). Due to rarity of AWDs, however, true prevalence of testicular maldescent among these boys is not known. We conducted a national register study to determine the prevalence of UDT among Finnish males with an AWD.MethodsAll male infants with either gastroschisis or omphalocele born between Jan 1, 1998 and Dec 31, 2015 were identified in the Register of Congenital Malformations. The data on all performed operations were acquired from the Care Register for Health Care. The register data were examined for relevant UDT diagnosis and operation codes.ResultsWe identified 99 males with gastroschisis and 89 with omphalocele. UDT was diagnosed in 10 (10.1%) infants with gastroschisis and 22 (24.7%) with omphalocele. Majority of these required an operation; 8/99 (8.1%) gastroschisis and 19/89 (21.3%) omphalocele patients. UDT is more common among AWD patients than general population with the highest prevalence in omphalocele.ConclusionsCryptorchidism is more common among boys with an AWD than general population. Furthermore, omphalocele carries significantly higher risk of UDT and need for orchidopexy than gastroschisis. Due to high prevalence testicular maldescent, careful follow-up for UDT is recommended.
“Get with the Guidelines Heart Failure Risk Score” for mortality prediction in patients undergoing MitraClip
Authors: Iliadis Christos , Spieker Maximilian , Kavsur Refik , Metze Clemens , Hellmich Martin , Horn Patrick , Westenfeld Ralf , Tiyerili Vedat , Becher Marc Ulrich , Kelm Malte , Nickenig Georg , Baldus Stephan , Pfister Roman 
Published: January 2021

Abstract
Background
Reliable risk scores in patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) are lacking. Heart failure is common in these patients, and risk scores derived from heart failure populations might help stratify TMVR patients.

Methods
Consecutive patients from three Heart Centers undergoing TMVR were enrolled to investigate the association of the “Get with the Guidelines Heart Failure Risk Score” (comprising the variables systolic blood pressure, urea nitrogen, blood sodium, age, heart rate, race, history of chronic obstructive lung disease) with all-cause mortality.

Results
Among 815 patients with available data 177 patients died during a median follow-up time of 365 days. Estimated 1-year mortality by quartiles of the score (0–37; 38–42, 43–46 and more than 46 points) was 6%, 10%, 23% and 30%, respectively (p < 0.001), with good concordance between observed and predicted mortality rates (goodness of fit test p = 0.46). Every increase of one score point was associated with a 9% increase in the hazard of mortality (95% CI 1.06–1.11%, p < 0.001). The score was associated with long-term mortality independently of left ventricular ejection fraction, NYHA class and NTproBNP, and was equally predictive in primary and secondary mitral regurgitation.

Conclusion
The “Get with the Guidelines Heart Failure Risk Score” showed a strong association with mortality in patients undergoing TMVR with additive information beyond traditional risk factors. Given the routinely available variables included in this score, application is easy and broadly possible.

Graphic abstract
Transcription factor ZmPLATZ2 positively regulate the starch synthesis in maize
Authors: Li Hui , Wang Yayun , Xiao Qianlin , Luo Li , Zhang Chunxia , Mao Changqing , Du Jia , Long Tiandan , Cao Yao , Yi Qiang , Wang Yongbin , Li Yangping , Huang Huanhuan , Liu Hanmei , Hu Yufeng , Yu Guowu , Liu Yinghong , Zhang Junjie , Huang Yubi 
Published: January 2021

AbstractMaize is one of the three major crops worldwide based on its yield and quality. Starch is crucial to both the yield and quality of maize as it accounts more than 60% of the seed weight, and its structure influences the quality of the crop. Starch synthase I (SSI) contributes to the majority of the starch synthase activity in the maize endosperm. An in-depth understanding of the starch synthesis regulatory mechanism would provide opportunities for improving the yield and quality of maize. In this study, ZmPLATZ2, a plant AT-rich sequence and zinc-binding protein (PLATZ) transcription factor related to starch synthesis, was selected based on co-expression analysis. The semiquantitative RT-PCR and qRT-PCR assays revealed that ZmPLATZ2 had a high expression in the endosperm, and reached the peak at 12 days after pollination (DAP). Different treatments demonstrated that ZmPLATZ2 was downregulated by the presence of sucrose. Subsequent transactivation and subcellular localization analyses showed that ZmPLATZ2 was localized in the nuclei without transactivation. Yeast one-hybrid and transient expression in maize endosperm indicated that ZmPLATZ2 could bind to the promoters of ZmSSI, ZmISA1, and ZmISA2 and increase their gene expression. After ZmPLATZ2 overexpression in rice, four starch synthesis genes were significantly upregulated in the transgenic plant, including the OsSSI gene. In vitro DAP-seq data showed that ZmPLATZ2 could bind to the CAAAAAAA element. In conclusion, our data support that ZmPLATZ2 binds to the CAAAAAAA element in the ZmSSI promoter and mediates the Glu signal pathway.
How Gender Differences in Entitlement and Apprehension Manifest Themselves in Negotiation
Authors: Mozahem Najib A. , El Masri Moniat El Noufous K. , Najm Nazhat M. , Saleh Samah S. 
Published: January 2021

AbstractThe gender difference in the propensity to initiate negotiation has been theorized to be mediated by three constructs: recognition of opportunities, entitlement, and apprehension. This study seeks to investigate whether differences in feminine and masculine traits can be used to explain gender differences in the three predictors of the propensity to initiate negotiations. Data was collected from 350 surveys distributed in Lebanon. Items were used to measure the constructs masculinity and femininity, as well as the three predictors of the propensity to initiate negotiation, namely Recognition of opportunities, Entitlement, and Apprehension. Confirmatory Factor Analysis was used to assess the validity of the measures, while structural equation modeling was used to investigate the relationship between the personality traits and the three constructs. Results indicate that masculinity enhances entitlement, which in turn leads to higher levels of negotiation while femininity enhances apprehension, which in turn leads to lower levels of negotiation. Both masculine and feminine traits were found to be positively related to the recognition of opportunities.
On sampling error in genetic programming
Authors: Schweim Dirk , Wittenberg David , Rothlauf Franz 
Published: January 2021

AbstractThe initial population in genetic programming (GP) should form a representative sample of all possible solutions (the search space). While large populations accurately approximate the distribution of possible solutions, small populations tend to incorporate a sampling error. This paper analyzes how the size of a GP population affects the sampling error and contributes to answering the question of how to size initial GP populations. First, we present a probabilistic model of the expected number of subtrees for GP populations initialized with full, grow, or ramped half-and-half. Second, based on our frequency model, we present a model that estimates the sampling error for a given GP population size. We validate our models empirically and show that, compared to smaller population sizes, our recommended population sizes largely reduce the sampling error of measured fitness values. Increasing the population sizes even more, however, does not considerably reduce the sampling error of fitness values. Last, we recommend population sizes for some widely used benchmark problem instances that result in a low sampling error. A low sampling error at initialization is necessary (but not sufficient) for a reliable search since lowering the sampling error means that the overall random variations in a random sample are reduced. Our results indicate that sampling error is a severe problem for GP, making large initial population sizes necessary to obtain a low sampling error. Our model allows practitioners of GP to determine a minimum initial population size so that the sampling error is lower than a threshold, given a confidence level.
Metal‐rich soils increase tropical tree stoichiometric distinctiveness
Authors: Trethowan Liam A. , Blonder Benjamin , Kintamani Endang , Girmansyah Deden , Utteridge Timothy M. A. , Brearley Francis Q. 
Published: January 2021

AbstractBackground and aimsUltramafic soils have high metal concentrations, offering a key opportunity to understand if such metals are strong predictors of leaf stoichiometry. This is particularly relevant for tropical forests where large knowledge gaps exist.MethodsOn the tropical island of Sulawesi, Indonesia, we sampled forests on sand, limestone, mafic and ultramafic soils that present a range of soil metal concentrations. We asked how variation in 12 soil elements (metals and macronutrients) influenced leaf stoichiometry and whether stoichiometric distinctiveness (the average difference between a species and all others in a multivariate space, the axes of which are the concentrations of each leaf element) is influenced by increasing soil metal concentrations.ResultsPositive correlations between corresponding elements in soils and leaves were only found for Ca and P. Noticeably, soil Cr had a negative effect upon leaf P. Whilst most species had low stoichiometric distinctiveness, some species had greater distinctiveness on stressful metal-rich ultramafic soils, generally caused by the accumulation of Al, Co, Cr or Ni.ConclusionsOur observation of increased stoichiometric distinctiveness in tropical forests on ultramafic soils indicates greater niche differentiation, and contrasts with the assumption that stressful environments remove species with extreme phenotypes.
Social Exclusion and Anti-Immigration Attitudes in Europe: The mediating role of Interpersonal Trust
Authors: Pellegrini Valerio , De Cristofaro Valeria , Salvati Marco , Giacomantonio Mauro , Leone Luigi 
Published: January 2021

AbstractManaging immigration is a challenge at the political, economic, and social levels. Clarifying the social psychological antecedents behind the onset of negative attitudes towards immigrants might help overcome this challenge. The present study investigates the relationships between people’s experience of social exclusion, feelings of generalized interpersonal trust, and anti-immigrant attitudes across 23 European countries. We used data from the European Social Survey 8 (2016), employing a representative sample of the European population. A 1–1–1 multilevel mediation model showed that: (a) the higher the experience of social exclusion, the lower the generalized trust towards others; (b) the experience of social exclusion related positively and directly with anti-immigration attitudes; and (c) generalized interpersonal trust mediated the relationship between experienced social exclusion and anti-immigrant attitudes so that the experience of being socially excluded reduced feelings of generalized interpersonal trust that, in turn, promoted hostile attitudes towards immigrants. Taken together, these results create a platform for future research on the emergence of negative attitudes towards immigrants and factors that might facilitate the development of a climate of integration and acceptance.
Why did the United States Evolve from the Largest International Creditor in 1980 to the Largest International Debtor in 1990?
Authors: Aliber Robert 
Published: January 2021

AbstractRemarkable transformation of the U.S. international investment position occurred over the last 40 years. U.S. net foreign assets were larger than combined net foreign assets of all other creditors. By 1990, foreign-owned U.S. securities and real assets were larger than U.S. owned foreign securities and assets. This change occurred without the U.S. Treasury borrowing in foreign currency and few U.S. firms borrowing, reflecting a surge in foreign purchases of U.S. securities. Inferences from the currency composition of portfolio changes of those who acquired U.S. dollar securities suggest that foreign savers took the initiative on cross-border investment inflows. The U.S. could not have developed a larger capital account surplus after 1980 unless a similar increase in the U.S. current account deficit occurred. The primary factor that led to the U.S. current account deficit increase was the surge in U.S. stocks and other asset prices, resulting in a U.S. household wealth surge and consumption boom. The foreign saving inflow displaced domestic saving. In addition, an increase in the price of the U.S. dollar led to expenditure-switching from U.S. goods to increasingly less expensive foreign goods. When investor demand for U.S. dollar securities declined, the U.S. dollar price fell in 1992, 2002, and 2020 and the price of U.S. dollar securities declined. The paper discusses the source of the change in the U.S. international investment position, the flow of foreign saving to the U.S., cyclical variability in the foreign saving flow to the U.S., and the potential impact of an adjustable parity arrangement.
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
Authors: Wirth Alexander , Wolf Bettina , Huang Cheng-Kai , Glage Silke , Hofer Sebastian J. , Bankstahl Marion , Bär Christian , Thum Thomas , Kahl Kai G. , Sigrist Stephan J. , Madeo Frank , Bankstahl Jens P. , Ponimaskin Evgeni 
Published: January 2021

AbstractAgeing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration.
Psychopaths and Symmetry: A Reply to Nelkin
Authors: Talbert Matthew 
Published: January 2021

AbstractAn agent is morally competent if she can respond to moral considerations. There is a debate about whether agents are open to moral blame only if they are morally competent, and Dana Nelkin’s “Psychopaths, Incorrigible Racists, and the Faces of Responsibility” is an important contribution to this debate. Like others involved in this dispute, Nelkin takes the case of the psychopath to be instructive. This is because psychopaths are similar to responsible agents insofar as they act deliberately and on judgments about reasons, and yet psychopaths lack moral competence. Nelkin argues that, because of their moral incompetence, vices such as cruelty are not attributable to psychopaths. It follows that psychopaths are not open to moral blame since their behavior is only seemingly vicious. I have three aims in this reply to Nelkin. First, I respond to her claim that psychopaths are not capable of cruelty. Second, I respond to the related proposal—embedded in Nelkin’s “symmetry argument”—that a “pro-social psychopath” would not be capable of kindness. My responses to these claims are unified: even if the psychopath is not capable of “cruelty,” and the pro-social psychopath is not capable of “kindness,” the actions of these agents can have a significance for us that properly engages our blaming and praising practices. Finally, I argue that Nelkin’s strategy for showing that moral competence is required for cruelty supports a stronger conclusion than she anticipates: it supports the conclusion that blameworthiness requires not just moral competence, but actual moral understanding.
Common Structure of Vision and Olfaction
Authors: Skrzypulec Błażej 
Published: January 2021

AbstractAccording to a common opinion, human olfactory experiences are significantly different from human visual experiences. For instance, olfaction seems to have only rudimentary abilities to represent space; it is not clear whether olfactory experiences have any mereological structure; and while vision presents the world in terms of objects, it is a matter of debate whether there are olfactory object-representations. This paper argues that despite these differences visual and olfactory experiences share a hierarchical subject/property structure. Within this structure, olfactorily experienced odours and visual objects have the same status: they are primary subjects which unify other represented elements into perceptual units.
Series of myocardial FDG uptake requiring considerations of myocardial abnormalities in FDG-PET/CT
Authors: Minamimoto Ryogo 
Published: January 2021

AbstractDistinct from cardiac PET performed with preparation to control physiological FDG uptake in the myocardium, standard FDG-PET/CT performed with 4–6 h of fasting will show variation in myocardial FDG uptake. For this reason, important signs of myocardial and pericardial abnormality revealed by myocardial FDG uptake tend to be overlooked. However, recognition of possible underlying disease will support further patient management to avoid complications due to the disease. This review demonstrates the mechanism of FDG uptake in the myocardium, discusses the factors affecting uptake, and provides notable image findings that may suggest underlying disease.
Introduction to tailored forming
Authors: Behrens B.-A. , Uhe J. 
Published: January 2021

AbstractIn recent years, the requirements for technical components have been increasing steadily. This development is intensified by the desire for products with lower weight, smaller size and extended functionality, but at the same time higher resistance against specific loads. Mono-material components manufactured according to established processes reach their limits regarding conflicting requirements. It is, for example, hardly possible to combine excellent mechanical properties with lightweight construction using mono-materials. Thus, a significant increase in production quality, lightweight design, functionality and efficiency can only be reached by combining different materials in one component. The superior aim of the Collaborative Research Centre (CRC) 1153 is to develop novel process chains for the production of hybrid solid components. In contrast to existing process chains in bulk metal forming, in which the joining process takes place during forming or at the end of the process chain, the CRC 1153 uses tailored semi-finished workpieces which are joined before the forming process. This results in a geometric and thermomechanical influence on the joining zone during the forming process which cannot be created by conventional joining techniques. The present work gives an overview of the CRC and the Tailored Forming approach including the applied joining, forming and finishing processes as well as a short summary of the accompanying design and evaluation methods.
[18F]FDG PET/MRI in rectal cancer
Authors: Crimì Filippo , Valeggia Silvia , Baffoni Luca , Stramare Roberto , Lacognata Carmelo , Spolverato Gaya , Albertoni Laura , Spimpolo Alessandro , Evangelista Laura , Zucchetta Pietro , Cecchin Diego , Pucciarelli Salvatore 
Published: January 2021

AbstractWe conducted a systematic literature review on the use of [18F]FDG PET/MRI for staging/restaging rectal cancer patients with PubMed, Scopus, and Web of Science, based on the PRISMA criteria. Three authors screened all titles and abstracts and examined the full texts of all the identified relevant articles. Studies containing aggregated or duplicated data, review articles, case reports, editorials, and letters were excluded. Ten reports met the inclusion criteria. Four studies examined T staging and one focused on local recurrences after surgery; the reported sensitivity (94–100%), specificity (73–94%), and accuracy (92–100%) varied only slightly from one study to another. The sensitivity, specificity, and accuracy of [18F]FDG PET/MRI for N staging were 90–93%, 92–94%, and 42–92%. [18F]FDG PET/MRI detected malignant nodes better than MRI, resulting in treatment change. For M staging, [18F]FDG PET/MRI outperformed [18F]FDG PET/CT and CT in detecting liver metastases, whereas it performed worse for lung metastases. The results of this review suggest that [18F]FDG PET/MRI should be used for rectal cancer restaging after chemoradiotherapy and to select patients for rectum-sparing approaches thanks to its accuracy in T and N staging. For M staging, it should be associated at least with a chest CT scan to rule out lung metastases.