bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation of a combinational iron chelating protoporphyrin IX prodrug for fluorescence detection and photodynamic therapy
Authors: Magnussen Anette , Reburn Charlotte , Perry Alexis , Wood Mark , Curnow Alison 
Published: July 2021

AbstractPhotodynamic therapy (PDT) is an oxygen-dependent, light-activated, and locally destructive drug treatment of cancer. Protoporphyrin IX (PpIX)-induced PDT exploits cancer cells’ own innate heme biosynthesis to hyper-accumulate the naturally fluorescent and photoactive precursor to heme, PpIX. This occurs as a result of administering heme precursors (e.g., aminolevulinic acid; ALA) because the final step of the pathway (the insertion of ferrous iron into PpIX by ferrochelatase to form heme) is relatively slow. Separate administration of an iron chelating agent has previously been demonstrated to significantly improve dermatological PpIX-PDT by further limiting heme production. A newly synthesized combinational iron chelating PpIX prodrug (AP2-18) has been assessed experimentally in cultured primary human cells of bladder and dermatological origin, as an alternative photosensitizing agent to ALA or its methyl or hexyl esters (MAL and HAL respectively) for photodetection/PDT. Findings indicated that the technique of iron chelation (either through the separate administration of the established hydroxypyridinone iron chelator CP94 or the just as effective combined AP2-18) did not enhance either PpIX fluorescence or PDT-induced (neutral red assessed) cell death in human primary normal and malignant bladder cells. However, 500 µM AP2-18 significantly increased PpIX accumulation and produced a trend of increased cell death within epithelial squamous carcinoma cells. PpIX accumulation destabilized the actin cytoskeleton in bladder cancer cells prior to PDT and resulted in caspase-3 cleavage/early apoptosis afterwards. AP2-18 iron chelation should continue to be investigated for the enhancement of dermatological PpIX-PDT applications but not bladder photodetection/PDT.
Natural history and treatment options of radiation-induced brain cavernomas: a systematic review
Authors: Patet Gildas , Bartoli Andrea , Meling Torstein R. 
Published: July 2021

AbstractRadiation-induced cavernous malformations (RICMs) are delayed complications of brain irradiation during childhood. Its natural history is largely unknown and its incidence may be underestimated as RCIMS tend to develop several years following radiation. No clear consensus exists regarding the long-term follow-up or treatment. A systematic review of Embase, Cochrane Library, PubMed, Google Scholar, and Web of Science databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was performed. Based on our inclusion/exclusion criteria, 12 articles were included, totaling 113 children with RICMs, 86 were treated conservatively, and 27 with microsurgery. We were unable to precisely define the incidence and natural history from this data. The mean age at radiation treatment was 7.3 years, with a slight male predominance (54%) and an average dose of 50.0 Gy. The mean time to detection of RICM was 9.2 years after radiation. RICM often developed at distance from the primary lesion, more specifically frontal (35%) and temporal lobe (34%). On average, 2.6 RICMs were discovered per child. Sixty-seven percent were asymptomatic. Twenty-one percent presented signs of hemorrhage. Clinical outcome was favorable in all children except in 2. Follow-up data were lacking in most of the studies. RICM is most often asymptomatic but probably an underestimated complication of cerebral irradiation in the pediatric population. Based on the radiological development of RICMs, many authors suggest a follow-up of at least 15 years. Studies suggest observation for asymptomatic lesions, while surgery is reserved for symptomatic growth, hemorrhage, or focal neurological deficits.
Guiding the evolution of product-line configurations
Authors: Nieke Michael , Sampaio Gabriela , Thüm Thomas , Seidl Christoph , Teixeira Leopoldo , Schaefer Ina 
Published: July 2021

AbstractA product line is an approach for systematically managing configuration options of customizable systems, usually by means of features. Products are generated for configurations consisting of selected features. Product-line evolution can lead to unintended changes to product behavior. We illustrate that updating configurations after product-line evolution requires decisions of both, domain engineers responsible for product-line evolution as well as application engineers responsible for configurations. The challenge is that domain and application engineers might not be able to interact with each other. We propose a formal foundation and a methodology that enables domain engineers to guide application engineers through configuration evolution by sharing knowledge on product-line evolution and by defining automatic update operations for configurations. As an effect, we enable knowledge transfer between those engineers without the need for interactions. We evaluate our methodology on four large-scale industrial product lines. The results of the qualitative evaluation indicate that our method is flexible enough for real-world product-line evolution. The quantitative evaluation indicates that we detect product behavior changes for up to $$55.3\%$$

55.3
%

of the configurations which would not have been detected using existing methods.
Home range size in central chimpanzees (Pan troglodytes troglodytes) from Loango National Park, Gabon
Authors: Martínez-Íñigo Laura , Baas Pauline , Klein Harmonie , Pika Simone , Deschner Tobias 
Published: July 2021

AbstractRanging behavior has been studied extensively in eastern (Pan troglodytes schweinfurthii)and western (P. t. verus) chimpanzees, but relatively little is known regarding home ranges of the other two subspecies (P. t. ellioti; P. t. troglodytes). In this study, we determined the home range size and space use of a habituated community (Rekambo) of central chimpanzees living in a habitat mosaic in Loango National Park, Gabon. Data on travel routes were collected during follows between January 2017 and April 2019 (N = 670,616 relocations, collected over 640 days and 5690 h of observation). We used three methods for calculating home range size (minimum convex polygon, kernel density estimation, and biased random bridges). We compare our estimates to those obtained from prior genetic and camera trap studies of the Rekambo community and contrast them with estimates from other chimpanzee communities of the four chimpanzee subspecies. Depending on the methodology used, the home range size of the Rekambo community ranged between 27.64 and 59.03 km2. The location of the center of the home range remained relatively stable over the last decade, while the overall size decreased. The Rekambo home range is, therefore, one of the largest documented so far for chimpanzees outside savannah-woodland habitats. We discuss several explanations, including the presence of savannah, interspecies competition, and intercommunity interactions.
Optimizing teacher basic need satisfaction in distributed healthcare contexts
Authors: Verhees M. J. M. , Engbers R. E. , Landstra A. M. , Bouwmans G. A. M. , Koksma J. J. , Laan R. F. J. M. 
Published: July 2021

AbstractOptimizing teacher motivation in distributed learning environments is paramount to ensure high-quality education, as medical education is increasingly becoming the responsibility of a larger variety of healthcare contexts. This study aims to explore teaching-related basic need satisfaction, e.g. teachers’ feelings of autonomy, competence and relatedness in teaching, in different healthcare contexts and to provide insight into its relation to contextual factors. We distributed a digital survey among healthcare professionals in university hospitals (UH), district teaching hospitals (DTH), and primary care (PC). We used the Teaching-related Basic Need Satisfaction scale, based on the Self-Determination theory, to measure teachers’ basic needs satisfaction in teaching. We studied relations between basic need satisfaction and perceived presence of contextual factors associated with teacher motivation drawn from the literature. Input from 1407 healthcare professionals was analyzed. PC healthcare professionals felt most autonomous, UH healthcare professionals felt most competent, and DTH healthcare professionals felt most related. Regardless of work context, teachers involved in educational design and who perceived more appreciation and developmental opportunities for teaching reported higher feelings of autonomy, competence, and relatedness in teaching, as did teachers who indicated that teaching was important at their job application. Perceived facilitators for teaching were associated with feeling more autonomous and related. These results can be utilized in a variety of healthcare contexts for improving teaching-related basic need satisfaction. Recommendations for practice include involving different healthcare professionals in educational development and coordination, forming communities of teachers across healthcare contexts, and addressing healthcare professionals’ intentions to be involved in education during job interviews.
Load-dependent power transfer efficiency for on-chip coils
Authors: Nilsson Joakim , Borg Johan , Johansson Jonny 
Published: July 2021

AbstractThis paper presents a theory for the power transfer efficiency of printed circuit board coils to integrated circuit coils, with focus on load-dependence for low-power single-chip systems. The theory is verified with electromagnetic simulations modelled on a 350 nm CMOS process which in turn are verified by measurements on manufactured integrated circuits. The power transfer efficiency is evaluated by on-chip rectification of a 151 MHz signal transmitted by a spiral coil on a printed circuit board at 10 mm of separation to an on-chip coil. Such an approach avoids the influence of off-chip parasitic elements such as bond wires, which would reduce the accuracy of the evaluation. It is found that there is a lower limit for the load below which reducing the power consumption of on-chip circuits yield no increase in voltage generated at the load. For the examined process technology, this limit appears to lie around 56 k$$\Omega$$
Ω
. The paper is focused on the analysis and verification of the theory behind this limit. We relate the results presented in this work to the application of wireless single-chip temperature monitoring of power semiconductors and conclude that such a system would be compatible with this limit.
Profit maximization in an inventory system with time-varying demand, partial backordering and discrete inventory cycle
Authors: San-José Luis A. , Sicilia Joaquín , González-de-la-Rosa Manuel , Febles-Acosta Jaime 
Published: July 2021

AbstractIn this paper, an inventory problem where the inventory cycle must be an integer multiple of a known basic period is considered. Furthermore, the demand rate in each basic period is a power time-dependent function. Shortages are allowed but, taking necessities or interests of the customers into account, only a fixed proportion of the demand during the stock-out period is satisfied with the arrival of the next replenishment. The costs related to the management of the inventory system are the ordering cost, the purchasing cost, the holding cost, the backordering cost and the lost sale cost. The problem is to determine the best inventory policy that maximizes the profit per unit time, which is the difference between the income obtained from the sales of the product and the sum of the previous costs. The modeling of the inventory problem leads to an integer nonlinear mathematical programming problem. To solve this problem, a new and efficient algorithm to calculate the optimal inventory cycle and the economic order quantity is proposed. Numerical examples are presented to illustrate how the algorithm works to determine the best inventory policies. A sensitivity analysis of the optimal policy with respect to some parameters of the inventory system is developed. Finally, conclusions and suggestions for future research lines are given.
Translational invasion ecology: bridging research and practice to address one of the greatest threats to biodiversity
Authors: Morelli Toni Lyn , Brown-Lima Carrie J. , Allen Jenica M. , Beaury Evelyn M. , Fusco Emily J. , Barker-Plotkin Audrey , Laginhas Brittany B. , Quirion Brendan R. , Griffin Bridget , McLaughlin Blair , Munro Lara , Olmstead Nancy , Richburg Julie , Bradley Bethany A. 
Published: July 2021

AbstractEffective natural resource management and policy is contingent on information generated by research. Conversely, the applicability of research depends on whether it is responsive to the needs and constraints of resource managers and policy makers. However, many scientific fields including invasion ecology suffer from a disconnect between research and practice. Despite strong socio-political imperatives, evidenced by extensive funding dedicated to addressing invasive species, the pairing of invasion ecology with stakeholder needs to support effective management and policy is lacking. As a potential solution, we propose translational invasion ecology (TIE). As an extension of translational ecology, as a framework to increase collaboration among scientists, practitioners, and policy makers to reduce negative impacts of invasive species. As an extension of translational ecology, TIE is an approach that embodies an intentional and inclusive process in which researchers, stakeholders, and decision makers collaborate to develop and implement ecological research via joint consideration of the ecological, sociological, economic, and/or political contexts in order to improve invasive species management. TIE ideally results in improved outcomes as well as shared benefits between researchers and managers. We delineate the steps of our proposed TIE approach and describe successful examples of ongoing TIE projects from the US and internationally. We suggest practical ways to begin incorporating TIE into research and management practices, including supporting boundary-spanning organizations and activities, expanding networks, sharing translational experiences, and measuring outcomes. We find that there is a need for strengthened boundary spanning, as well as funding and recognition for advancing translational approaches. As climate change and globalization exacerbate invasive species impacts, TIE provides a promising approach to generate actionable ecological research while improving outcomes of invasive species management and policy decisions.
Preparation and characterization of bionanocomposite films based on wheat starch and reinforced with cellulose nanocrystals
Authors: Montero Belén , Rico Maite , Barral Luis , Bouza Rebeca , López Joaquín , Schmidt Anja , Bittmann-Hennes Birgit 
Published: July 2021

AbstractIn recent times, the attention of scientific community has been focusing on the replacement of petroleum-based polymers by others more environmentally friendly. In this sense, bionanocomposites based on glycerol-plasticized wheat starch and reinforced with cellulose nanocrystals (CNCs) were prepared by a solvent-casting process to obtain environmentally friendly films. The plasticization process was proven to be complete in the conditions used and no residual crystallinity was observed in any case. The incorporation of CNCs leads to materials with increased rigidity (about 1000% increment in modulus) which is related to a good filler-matrix interaction and to the formation of a rigid crystalline network of cellulose. This fact allowed also to improve the moisture resistance and the barrier properties (in both, oxygen and water vapor as permeant) of the bionanocomposite films due to the formation of a tortuous path, which prevent the gas diffusion. Moreover, the thermal stability of films was not affected by the filler incorporation. These improvements in the properties make these films susceptible to be used in short-time applications in the food packaging industry.
Spray coating of cellulose aerogel particles in a miniaturized spouted bed
Authors: Schroeter Baldur , Yonkova Velislava P. , Goslinska Monika , Orth Maike , Pietsch Swantje , Gurikov Pavel , Smirnova Irina , Heinrich Stefan 
Published: July 2021

AbstractAim of this work is to apply protective and homogeneous shellac coating layers on the surface of hydrophilic open-pore cellulose aerogel particles with low densities ≤ 0.1 g/cm3 and high specific surface areas in the range of ~ 400–450 m2/g while keeping the aerogels’ microstructure intact during processing. For this purpose, an innovative miniaturized spouted bed setup was used. Successful process settings for application of enclosed films on aerogel surfaces without intrusion of coating material into the pores were determined. Precise control of coating layer thickness in the range of 10–50 µm was achieved due to variation of coating solution amount without agglomeration and clogging events occurring during processing. Comparison of bulk densities and specific surface areas before and after coating proved the intactness of the porous structure. Coating of particles loaded with vanillin led to controlled release, enhancing release half-life times from 20 to 1600 min. Overall, a successful strategy for coating of organic low-density aerogels was developed.
Diagonal groups and arcs over groups
Authors: Bailey R. A. , Cameron Peter J. , Kinyon Michael , Praeger Cheryl E. 
Published: July 2021

AbstractIn an earlier paper by three of the present authors and Csaba Schneider, it was shown that, for $$m\ge 2$$

m
≥
2

, a set of $$m+1$$

m
+
1

partitions of a set $$\Omega $$
Ω
, any m of which are the minimal non-trivial elements of a Cartesian lattice, either form a Latin square (if $$m=2$$

m
=
2

), or generate a join-semilattice of dimension m associated with a diagonal group over a base group G. In this paper we investigate what happens if we have $$m+r$$

m
+
r

partitions with $$r\ge 2$$

r
≥
2

, any m of which are minimal elements of a Cartesian lattice. If $$m=2$$

m
=
2

, this is just a set of mutually orthogonal Latin squares. We consider the case where all these squares are isotopic to Cayley tables of groups, and give an example to show the groups need not be all isomorphic. For $$m>2$$

m
>
2

, things are more restricted. Any $$m+1$$

m
+
1

of the partitions generate a join-semilattice admitting a diagonal group over a group G. It may be that the groups are all isomorphic, though we cannot prove this. Under an extra hypothesis, we show that G must be abelian and must have three fixed-point-free automorphisms whose product is the identity. (We describe explicitly all abelian groups having such automorphisms.) Under this hypothesis, the structure gives an orthogonal array, and conversely in some cases. If the group is cyclic of prime order p, then the structure corresponds exactly to an arc of cardinality $$m+r$$

m
+
r

in the $$(m-1)$$

(
m
-
1
)

-dimensional projective space over the field with p elements, so all known results about arcs are applicable. More generally, arcs over a finite field of order q give examples where G is the elementary abelian group of order q. These examples can be lifted to non-elementary abelian groups using p-adic techniques.
An indicator-based sustainability assessment method for indigenous communities: a case study from Mexico
Authors: Molina Maturano Jessica , García Serrano Luz A. , Carmona García Juan A. , García de Alva Magos Mayela A. , Hersperger Anna M. 
Published: July 2021

AbstractIndigenous and Western communities are faced with increasing issues of sustainability compromising their natural resources and cultural heritage, for example, a cross-pollination/complementary approach in relation to their current knowledge systems and discourses on sustainability. There is a need for methods that integrate different discourses relating to sustainability to identify the most pressing needs in terms of sustainability. Sustainability assessments are a type of impact assessment that focus on enhanced sustainability both now and in the future; however, the literature on indigenous sustainability assessment methods, is scarce. To address this gap, we have developed a novel Sustainability Assessment method for Indigenous Communities (SAIC). The SAIC method combines Western and indigenous sustainability objectives and principles, in order to extend the range of options for action to address sustainability. The SAIC method consists of two sections (i) values and considerations and (ii) procedure. The “values and considerations” section establishes the fundamental participatory and ethical considerations for conducting sustainability assessments in indigenous communities, and the “procedure” section establishes a set of 55 indicators in eight categories. The method was tested in a Zapotec, indigenous community in México. Results show that this community was rated highly in all eight categories. However, indicators for family planning and access to health services were rated poorly. The identified issues can be used as guidelines for decision making in future regional projects and development plans. The results reveal further areas for improvement, such as strengthening the links to national or international networks and increasing the use of renewable energies. The method presented in this paper provides an assessment approach based on Western and indigenous sustainability discourses, which is suitable for assessing indigenous communities.
The moderating effect of collective efficacy on the relationship between environmental values and ecological behaviors
Authors: Cuadrado E. , Macias-Zambrano L. H. , Carpio A. J. , Tabernero C. 
Published: July 2021

AbstractSustainability implies improvements in responsible behaviors such as recycling and energy saving. Yet, ecological behaviors cannot be improved only by attending to personal variables; focus must also be put on the collective variables. The main aim of this research was to analyze how individual variables (environmental values) and collective variables (collective efficacy for ecological behavior) interact to explain recycling (Study 1; 502 students of Spanish universities) and energy-saving behaviors (Study 2; 544 students of Ecuadorian universities). Participants completed an online questionnaire that reflected all the studied variables. Ecological behaviors were collected through frequency scales. The results of the moderated analyses performed with Process for SPSS confirmed the moderating effect of collective efficacy in the relationship that both preservation and appreciation established with recycling and energy-saving behavior alike. This moderating effect was also confirmed in the relationship that utilization developed with recycling, but not with energy saving. Thus, collective efficacy directly influences pro-environmental behavior, but also interacts with the personal values of individuals. Consequently, the results indicate the need to encourage collective efficacy for ecological behaviors of individuals, groups, collectives, and communities.