bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effect of gelatin on iron gall ink corrosion
Authors: Gimat Alice , Michelin Anne , Massiani Pascale , Rouchon Véronique 
Published: October 2021

Abstract
Iron gall Inks corrosion causes paper degradation (browning, embrittlement) and treatments were developed to tackle this issue. They often include resizing with gelatin to reinforce the paper and its cellulosic fibers (of diameter approx. 10 µm). This work aimed at measuring the distribution of ink components at the scale of individual paper fibers so as to give a better understanding of the impact of gelatin (re-)sizing on iron gall ink corrosion. For this purpose, scanning transmission X-ray microscopy (STXM) was used at the Canadian light source synchrotron (CLS, Saskatoon). This technique combines nano-scale mapping (resolution of 30 nm) and near edge X-ray absorption fine structure (NEXAFS) analysis. Fe L-edge measurements enabled to map iron distribution and to locate iron(II) and iron(III) rich areas. N K-edge measurement made it possible to map gelatin distribution. C K-edge measurements allowed mapping and discrimination of cellulose, gallic acid, iron gall ink precipitate and gelatin. Three fibers were studied: an inked fiber with no size, a sized fiber that was afterwards inked and an inked fiber sprayed with gelatin. Analysis of gelatin and ink ingredients distribution indicated a lower amount of iron inside the treated cellulosic fiber, which may explain the beneficial effect of gelatin on iron gall ink corrosion.
Computed tomographic assessment of lung aeration at different positive end-expiratory pressures in a porcine model of intra-abdominal hypertension and lung injury
Authors: Regli Adrian , Ahmadi-Noorbakhsh Siavash , Musk Gabrielle Christine , Reese David Joseph , Herrmann Peter , Firth Martin Joseph , Pillow J. Jane 
Published: October 2021

Abstract
Background
Intra-abdominal hypertension (IAH) is common in critically ill patients and is associated with increased morbidity and mortality. High positive end-expiratory pressures (PEEP) can reverse lung volume and oxygenation decline caused by IAH, but its impact on alveolar overdistension is less clear. We aimed to find a PEEP range that would be high enough to reduce atelectasis, while low enough to minimize alveolar overdistention in the presence of IAH and lung injury.

Methods
Five anesthetized pigs received standardized anesthesia and mechanical ventilation. Peritoneal insufflation of air was used to generate intra-abdominal pressure of 27 cmH2O. Lung injury was created by intravenous oleic acid. PEEP levels of 5, 12, 17, 22, and 27 cmH2O were applied. We performed computed tomography and measured arterial oxygen levels, respiratory mechanics, and cardiac output 5 min after each new PEEP level. The proportion of overdistended, normally aerated, poorly aerated, and non-aerated atelectatic lung tissue was calculated based on Hounsfield units.

Results
PEEP decreased the proportion of poorly aerated and atelectatic lung, while increasing normally aerated lung. Overdistension increased with each incremental increase in applied PEEP. “Best PEEP” (respiratory mechanics or oxygenation) was higher than the “optimal CT inflation PEEP range” (difference between lower inflection points of atelectatic and overdistended lung) in healthy and injured lungs.

Conclusions
Our findings in a large animal model suggest that titrating a PEEP to respiratory mechanics or oxygenation in the presence of IAH is associated with increased alveolar overdistension.
Earth-affecting solar transients: a review of progresses in solar cycle 24
Authors: Zhang Jie , Temmer Manuela , Gopalswamy Nat , Malandraki Olga , Nitta Nariaki V. , Patsourakos Spiros , Shen Fang , Vršnak Bojan , Wang Yuming , Webb David , Desai Mihir I. , Dissauer Karin , Dresing Nina , Dumbović Mateja , Feng Xueshang , Heinemann Stephan G. , Laurenza Monica , Lugaz Noé , Zhuang Bin 
Published: October 2021

AbstractThis review article summarizes the advancement in the studies of Earth-affecting solar transients in the last decade that encompasses most of solar cycle 24. It is a part of the effort of the International Study of Earth-affecting Solar Transients (ISEST) project, sponsored by the SCOSTEP/VarSITI program (2014–2018). The Sun-Earth is an integrated physical system in which the space environment of the Earth sustains continuous influence from mass, magnetic field, and radiation energy output of the Sun in varying timescales from minutes to millennium. This article addresses short timescale events, from minutes to days that directly cause transient disturbances in the Earth’s space environment and generate intense adverse effects on advanced technological systems of human society. Such transient events largely fall into the following four types: (1) solar flares, (2) coronal mass ejections (CMEs) including their interplanetary counterparts ICMEs, (3) solar energetic particle (SEP) events, and (4) stream interaction regions (SIRs) including corotating interaction regions (CIRs). In the last decade, the unprecedented multi-viewpoint observations of the Sun from space, enabled by STEREO Ahead/Behind spacecraft in combination with a suite of observatories along the Sun-Earth lines, have provided much more accurate and global measurements of the size, speed, propagation direction, and morphology of CMEs in both 3D and over a large volume in the heliosphere. Many CMEs, fast ones, in particular, can be clearly characterized as a two-front (shock front plus ejecta front) and three-part (bright ejecta front, dark cavity, and bright core) structure. Drag-based kinematic models of CMEs are developed to interpret CME propagation in the heliosphere and are applied to predict their arrival times at 1 AU in an efficient manner. Several advanced MHD models have been developed to simulate realistic CME events from the initiation on the Sun until their arrival at 1 AU. Much progress has been made on detailed kinematic and dynamic behaviors of CMEs, including non-radial motion, rotation and deformation of CMEs, CME-CME interaction, and stealth CMEs and problematic ICMEs. The knowledge about SEPs has also been significantly improved. An outlook of how to address critical issues related to Earth-affecting solar transients concludes this article.
Masting effect on alpha and beta avian diversity in fragmented forests of relict-endangered Mexican Beech (Fagus grandifolia subsp. mexicana)
Authors: Rodríguez-Ramírez Ernesto C. , Camacho-Islas Levinn , Martínez-Falcón Ana Paola , Luna-Vega Isolda , Carbó-Ramírez Pilar 
Published: October 2021

AbstractBackgroundTropical montane cloud forests are one of the most important hotspots on Earth and show presence of relict-endemic and endangered species, representing about 14% of the total tropical forest worldwide. Synchronous seed production or masting in tropical montane cloud tree species is a widespread reproductive strategy of deciduous and evergreen broad-leaved tree associations to decrease costs of reproduction and ensure offspring. Masting event maintains a high avian diversity, which can be modified by phenological process (seed production and non-seed production).MethodsThe main aim of this study was to assess alpha and beta avian diversity and whether the composition of the trophic guild modifies among phenological processes and between two fragmented relict-endangered Mexican Beech (Fagus grandifoliasubsp.mexicana) forests (Medio Monte and El Gosco) in the Mexican state of Hidalgo. In addition, we evaluated beechnut production.ResultsWe recorded 36 bird species, 11 of them included in some conservation risk status, and 5 endemic species. Alpha diversity values were dissimilar in avian richness (q = 0) among phenological processes and between fragmented beech forests. Avian communities among three phenological processes and between fragmented forests were structurally similar, dominated during immature seeds the Brown-backed Solitaire (granivores–insectivores–frugivores); during mature seeds the White-crowned Parrot (Pionus senilis, granivores–frugivores); and the Dwarf Jay (Cyanolyca nana, insectivores) was abundant during low seed quality. The complementarity index was high among phenological processes and low between forests. We found a high bird turnover value between immature seeds—mature seeds and during mature seeds—low seed quality. Furthermore, a similar pattern was recorded between the two study forests. Seed production showed a high number of undamaged beechnuts in Medio Monte, while in El Gosco beechnuts were attacked by insects.ConclusionsOur results reflect that masting phenological process and contrasting study forests’ structure influence the shifts in alpha and beta diversity of seed and non-seed bird consumers. Our study reaffirms the importance of continuing studies throughout masting in all the Mexican Beech forests to address regional efforts in preserving the relict-ecological interactions.
Chronic systemic capillary leak syndrome associated with an intravascular large B-cell lymphoma in a patient undergoing hemodialysis: a case report with literature review
Authors: Sunohara Keisuke , Shimizu Rie , Yasuda Kazushi , Owaki Akiko , Nagaya Hiroshi , Kajiguchi Tomohiro , Inaba Shinichiro 
Published: October 2021

Abstract
Background
Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by hypotension, hemoconcentration, and hypoalbuminemia associated with increased capillary endothelium permeability. Patients with a chronic form of SCLS present with persistent and progressive generalized edema. However, there have been no reports of chronic SCLS in patients undergoing hemodialysis. Herein, we report a case of chronic SCLS associated with an intravascular large B-cell lymphoma (IVLBCL) in a patient undergoing hemodialysis.

Case presentation
A 71-year-old male had been on hemodialysis for five years due to diabetic nephropathy. Difficulty in body fluid removal was observed during hemodialysis, and the patient was admitted to our hospital due to exacerbated weight gain and lower limb edema. He had elevated serum lactate dehydrogenase (LDH) levels and thrombocytopenia. His blood pressure was low, and his serum brain natriuretic peptide level was relatively low, despite the increase in body fluid volume. His clinical characteristics suggested a chronic form of SCLS. Random skin biopsy revealed IVLBCL; however, the association between IVLBCL and chronic SCLS remained unclear. He underwent chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone, followed by rituximab. After the treatment, his serum LDH level decreased, and the difficulty in body fluid removal during hemodialysis improved. The patient’s chronic SCLS seemed to be complicated by IVLBCL.

Conclusions
Patients with chronic SCLS who are undergoing hemodialysis seem to present with difficulties in fluid removal. The frequency of SCLS complications in cases with malignant lymphomas, including IVLBCL, is considered to be extremely low. However, clinicians should be aware of SCLS as a complication of malignant lymphomas.
Ameliorative activity of medicinal plant fraction for neuroprotection against acrylamide-induced neurotoxicity in Drosophila melanogaster—a comparative study
Authors: Pratap G. K. , Ananda Danagoudar , Joshi Chandrashekhar G. , Shantaram Manjula 
Published: October 2021

Abstract
Background
Medicinal plant extracts used in folk medicine seem to be crucial since those are generally accepted by people without worrying about the toxicity. In our present study, we have compared the neuroprotective role of the rhizome of Curculigo orchioides Gaertn. and leaf extracts of Olea dioica Roxb., against acrylamide-induced neurotoxicity in Drosophila melanogaster.

Results
In-vivo neurotoxic study was carried out using 7-day-old flies (wild-type D. melanogaster). Prior to co-after exposing the flies with acrylamide (8 mM) along with or without OLE-2 and CU-3 fractions (0.2, 0.4 and 0.6% w/v), the heads of flies of both the control and treated groups were homogenized for biochemical assay. ACR-treated groups have shown higher elevation in AChE, SOD, LPO, and CAT activity when compared to control and treated (plant fraction) groups. Biochemical and histopathology studies show that both the plant fractions (OLE-2 and CU-3) have neuroprotective action against acrylamide.

Conclusion
The present study has demonstrated that dietary supplementation with plant fraction of OLE-2 and CU-3 has increased antioxidant enzymes and decreased AChE activity in D. melanogaster. This activity could be part of the probable mechanisms of action by which OLE-2 and CU-3 fractions have extended the lifespan and locomotory activity in fruit flies. These fruit flies continue to provide an exciting system for metabolic studies and should be more extensively exploited. Based on these results, further studies on the identified bioactive compounds from these two plants are being planned.
Gene cloning, recombinant expression, and bioassay of an allatotropin in Spodoptera litura Fabricius (Lepidoptera: Noctuidae)
Authors: Mamtha R. , Kiran Tannavi , Chaitra B. S. , Saraswathi Saraswathi , Sowrabha R. , Rao Karthik V. , Manjulakumari D. 
Published: October 2021

AbstractBackgroundAllatotropin, a neuropeptide found in several invertebrates indirectly regulates vitellogenesis by stimulating juvenile hormone biosynthesis by the corpora allata. Here, we cloned and expressed the gene encoding allatotropin ofSpodoptera litura(tobacco cutworm), a polyphagous pest in the Asian tropics. This study is aimed at studying the effect of recombinant protein on egg-laying in females ofS. lituraas it could be used as a method to control the pests from a reproductive perspective.ResultsThe protein encodes a full-length open reading frame consisting of 173 amino acids and was rich in arginine (10%) and glutamic acid (9.3%). The theoretical pI of the protein was 5.47 and a hydrophobic signal peptide of 22 residues was predicted. The recombinant allatotropin was expressed inEscherichia coliBL21 (DE3) and purified by nickel exchange chromatography. The molecular weight of the recombinant protein was about 37 kDa and expression levels up to 5.3 mg/ml were achieved. Injection assay in vitro indicated that allatotropin induces egg-laying during the first scotophase after treatment in females ofSpodoptera litura.ConclusionAllatotropin induces egg-laying in female moths and could be a potential molecule for the development of control strategies againstSpodoptera litura. In this strategy, the protein if delivered to the females before mating may lead to accelerated egg deposition much before she encounters the male moths, thus the population being checked as the eggs deposited by the females are unfertilized. Thus, the present work could lead to the development of a protein based biopesticide resulting into a species-specific and an eco-friendly way of pest control.
Microbial taxa in dust and excreta associated with the productive performance of commercial meat chicken flocks
Authors: Bindari Yugal Raj , Moore Robert J. , Van Thi Thu Hao , Walkden-Brown Stephen W. , Gerber Priscilla F. 
Published: October 2021

Abstract
Background
A major focus of research on the gut microbiota of poultry has been to define signatures of a healthy gut and identify microbiota components that correlate with feed conversion. However, there is a high variation in individual gut microbiota profiles and their association with performance. Population level samples such as dust and pooled excreta could be useful to investigate bacterial signatures associated with productivity at the flock-level. This study was designed to investigate the bacterial signatures of high and low-performing commercial meat chicken farms in dust and pooled excreta samples. Poultry house dust and fresh pooled excreta were collected at days 7, 14, 21, 28 and 35 of age from 8 farms of two Australian integrator companies and 389 samples assessed by 16S ribosomal RNA gene amplicon sequencing. The farms were ranked as low (n = 4) or high performers (n = 4) based on feed conversion rate corrected by body weight.

Results
Permutational analysis of variance based on Bray–Curtis dissimilarities using abundance data for bacterial community structure results showed that company explained the highest variation in the bacterial community structure in excreta (R2 = 0.21, p = 0.001) while age explained the highest variation in the bacterial community structure in dust (R2 = 0.13, p = 0.001). Farm performance explained the least variation in the bacterial community structure in both dust (R2 = 0.03, p = 0.001) and excreta (R2 = 0.01, p = 0.001) samples. However, specific bacterial taxa were found to be associated with high and low performance in both dust and excreta. The bacteria taxa associated with high-performing farms in dust or excreta found in this study were Enterococcus and Candidatus Arthromitus whereas bacterial taxa associated with low-performing farms included Nocardia, Lapillococcus, Brachybacterium, Ruania, Dietzia, Brevibacterium, Jeotgalicoccus, Corynebacterium and Aerococcus.

Conclusions
Dust and excreta could be useful for investigating bacterial signatures associated with high and low performance in commercial poultry farms. Further studies on a larger number of farms are needed to determine if the bacterial signatures found in this study are reproducible.
Reduced receptor for advanced glycation end products is associated with α-SMA expression in patients with idiopathic pulmonary fibrosis and mice
Authors: Baek Hyosin , Jang Soojin , Park Jaehyun , Jang Jimin , Lee Jooyeon , Hong Seok-Ho , Kim Woo Jin , Park Sung-Min , Yang Se-Ran 
Published: October 2021

AbstractBackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. Despite alveolar epithelial cells is crucial role in lung, its contribution and the associated biomarker remain unknown in the pathogenesis of IPF. Recently, environmental factors including stone dust, silica and cigarette smoking were found as risk factors involved in IPF. Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin super family of cell surface receptors. It has been shown that interaction between RAGE and its ligands on immune cells mediates cellular migration and regulation of pro-inflammation. RAGE is highly expressed in the lung, in particular, alveolar epithelial cells. Therefore, we determined whether RAGE expression is associated with fibrosis-associated genes in patients with IPF and mice.ResultsWhen bleomycin (BLM) was intratracheally administered to C57BL/6 mice for 1, 2 weeks, macrophage and neutrophils were significantly increased. The fibrotic nodule formed and accumulation of collagen was determined after BLM injection in H&E- and Masson’s trichrome staining. Levels of elastin, Col1a1 and fibronectin were increased in quantitative real-time PCR and protein levels of α-SMA was increased in western blot analysis. In the lung tissues of 1 mg/kg BLM-induced mice, RAGE expression was gradually decreased in 1- and 2 weeks in immunohistochemistry and western blot analysis, and 3 mg/kg of BLM-induced mice exhibited decreased RAGE levels while α-SMA expression was increased. We next determined RAGE expression in the lungs of IPF patients using immunohistochemistry. As a result, RAGE expression was decreased, while α-SMA expression was increased compared with non-IPF subjects.ConclusionsOur findings suggest that reduced RAGE was associated with increased fibrotic genes in BLM-induced mice and patients with IPF. Therefore, RAGE could be applied with a biomarker for prognosis and diagnosis in the pathogenesis of IPF.
FLAIR vascular hyperintensity, an early sign of stroke (case report)
Authors: Kamr Wael Hamza , Almalki Mohannad Saeed , Saadawy Amr M. Ismaeel , El-Tahan Ayman 
Published: October 2021

Abstract
Background
Generally, Diffusion-weighted MR imaging (DWI) is known to be more sensitive in diagnosis of acute stroke than other MR sequences. However, fluid attenuated inversion recovery (FLAIR) MR sequence founded to be sometimes more sensitive compared to DWI for the diagnosis of hyperacute stroke.

Case presentation
An 84 years old female patient brought to ER by ambulance due to loss of speech, dizziness and confusion. Neurological examination showed that the patient can raise her left hand and leg while partially moving her right hand and right leg. The patient had slurred speech. Provisional diagnosis was acute stroke and the patient admitted in the hospital. Non contrast CT scan of the brain was done, was negative for stroke. Then MRI was done showed no areas of restricted diffusion at the DWI sequence or ADC map. Prominent high signal vessels at the left temporal region and on Sylvian fissure were noticed on FLAIR sequence that might have suggested early sign of ischemic vascular insult.

Conclusions
Arterial hyperintensity on FLAIR images can precede diffusion abnormalities and may provide a clue to the early detection of impending infarction.
Negative effects of psychotherapy: estimating the prevalence in a random national sample
Authors: Strauss Bernhard , Gawlytta Romina , Schleu Andrea , Frenzl Dominique 
Published: October 2021

Background
Negative or adverse effects of psychological treatments are increasingly a focus of psychotherapy research. Yet, we still know little about the prevalence of these effects.

Aims
Starting from a representative national sample, the prevalence of negative effects and malpractice was determined in a subsample of individuals reporting psychotherapy currently or during the past 6 years.

Method
Out of an initial representative sample of 5562 individuals, 244 were determined to have had psychotherapy within the past 6 years. Besides answering questions related to treatment, its effects and the therapists, patients filled out the Negative Effects Questionnaire, items of the Inventory of Negative Effects of Psychotherapy reflecting malpractice and the Helping Alliance Questionnaire, and rated psychotherapeutic changes in different areas.

Results
Rates of positive changes related to therapy varied between 26.6% (relationship to parents) and 67.7% (improvement in depressed mood). Deteriorations were most commonly related to physical well-being (13.1%), ability to work (13.1%) and vitality (11.1%). Although patients generally reported a positive helping alliance, many of them reported high rates of negative effects (though not always linked to treatment). This was especially true of the experience of unpleasant memories (57.8%), unpleasant feelings (30.3%) and a lack of understanding of the treatment/therapist (19.3/18.4%). Indicators of malpractice were less common, with the exception that 16.8% felt violated by statements of their therapist.

Conclusions
This study helps to better estimate aspects of negative effects in psychotherapy ranging from deteriorations, specific effects and issues of malpractice that should be replicated and specified in future studies.