bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Design Method of Hydrogen Storage Pressure Vessel in the Hydrogen Refueling Station Based on Failure Mode
Authors: Ji Fang , Jia Xiaoliang , Chen Zhiwei , Liu Cenfan , Duan Linlin 
Published: October 2021

Abstract
With the rapid development and industrialization of hydrogen fuel cells and electric vehicles, safe and efficient hydrogen storage technology has become the main bottleneck for the development of hydrogen energy. As an important supporting facility of hydrogen fuel cell vehicles, the hydrogen storage mode adopted by hydrogen refueling station is mainly high-pressure hydrogen storage. Hydrogen storage pressure vessel as the main core equipment of hydrogen refueling station, its storage pressure is high, the hydrogen is flammable and explosive, has the potential leakage and explosion risk, its safety is particularly important. At present, there is still a lack of relevant research on the mechanical properties of materials used in hydrogen storage vessels in high-pressure hydrogen atmosphere in China, and there are still huge safety risks in the design and calculation of hydrogen storage pressure vessels in hydrogen refueling stations. So, this paper summarizes the characteristics and typical failure modes of hydrogen storage vessels in hydrogen refueling stations, give the assessment methods for each failure mode and the test scheme for measuring the materials mechanical properties data in hydrogen atmosphere used in the failure assessment. The design method based on the failure mode for hydrogen storage pressure vessels in hydrogen refueling stations is proposed in the paper.
Effect of Parameters of Elasto-Plastic Damper on Mitigation of Connected Cabinets Storing Electronics Subjected to Seismic Waves
Authors: Shintani Atsuhiko , Yoshida Takuma , Nakagawa Chihiro , Ito Tomohiro 
Published: October 2021

Abstract
In this paper, the mitigation of the seismic response of connected cabinets and the electronics inside them when using elasto-plastic dampers installed between cabinets is reported. In many plants, such as power and chemical plants, several rectangular cabinets, which contain electronics, are set directly on the floor in the buildings. The electronics inside the cabinets are extremely important for controlling the behavior of the plant. When an earthquake occurs, the cabinets and inside electronics overturned by a rocking motion and may be damaged or destroyed. Even if the cabinets are not overturned, there is a concern that large accelerations will be applied to the internal electronics owing to the seismic wave. As a result, the full plant cannot be controlled, and a serious accident may occur. Therefore, it is necessary to develop methods that can simultaneously reduce rocking motion and prevent internal electronic damage. In some cases, the cabinets cannot be connected to the wall or floor for a particular reason. Even in this case, connecting the adjacent cabinets with an elasto-plastic damper, which is a nonlinear damper, can mitigate the vibrations of the cabinets and electronics. We consider the behavior of adjacent cabinets with electronics connected using two elasto-plastic dampers. The cabinets are modelled by the rigid bodies rotating around their corners, and the internal electronics are modeled as rigid bodies moving in the translational direction in the cabinets. The elasto-plastic damper has bilinear hysteretic characteristics and can absorb the energy of the earthquake inputs. The rocking behaviors of the cabinets and accelerations of the electronics are investigated when the seismic wave is input to the connecting cabinets storing the electronics. The effects of the elasto-plastic damper on the mitigation of the rocking motions of the cabinets and the accelerations of the electronics were investigated. In particular, the attachment positions of the elasto-plastic dampers are important parameters for reducing the vibrations of the cabinets and electronics. Finally, the effects of the attachment position of the elasto-plastic damper are discussed.
Fracture Analysis of Reactor Pressure Vessel Lower Head Considering Core Meltdown Accident
Authors: Dubyk Yaroslav , Antonchenko Vitalii , Zarazovskii Maksym 
Published: October 2021

Abstract
This paper presents fracture mechanics analysis for highly loaded reactor pressure vessel (RPV) of the WWER-440/213 unit during in-vessel core melt retention (IVMR) scenario. In-Vessel Core Melt Retention strategy via external vessel cooling is widely applied for reactors of relatively low power like WWER-440. During the IVRM a reactor pressure vessel is affected by huge thermal loading from molted core (a source of heat generation), also internal pressure may be present. To resist these loadings RPV is cooled from the outer surface by the flooding of the reactor cavity. This may lead to thermal shock conditions, as we obtain a huge temperature gradient through the RPV wall, with relative cold water on the outer surface.
The calculations were performed using global 2D RPV model and local 3D sub-model with crack embedded into mesh for J-integral evaluations. First 2D RPV model was used to calculate the global stress-strain state of the RPV. During the calculation plasticity and creep material behavior was considered, as well as melt of the fuel elements during calculation, which were ‘killed’ (excluded) when their temperature was above the melting line. Then a 3D sub-model with crack was calculated, with boundary conditions taken from the 2D axisymmetric analysis. Finally, a J-integral was evaluated according several procedures. Different crack positions are considered, as well as different crack axis ratio. Conclusions were drawn about applications of J-integral procedures for such a highly loaded scenario.
Evaluation of Hydrogen Embrittlement Behaviors in Pipeline Steel Welds Using In-Situ SP Test In High-Pressure Hydrogen Environments
Authors: Shin Hyung-Seop , Custodio N. A. , Yeo Juho , Cho Jae-Won , Baek Un-Bong , Nahm Seung-Hoon 
Published: October 2021

Abstract
A simple screening technique of hydrogen embrittlement (HE) of steels for hydrogen energy facilities using an in-situ small-punch (SP) test method under external hydrogen condition has been established. Using this method, we investigated the HE behaviors of API X70 steel welds under test conditions mimicking pipeline operating environments. The HE sensitivity at each region of the base metal, heat-affected zone, and weld metal of the steel weld was examined qualitatively and quantitatively and compared to one another. Under 8 MPa H2 gas, the welds showed pronounced HE: the HE behaviors induced were similar across all tested regions. This shows that the in-situ SP test is effective for screening HE susceptibility of pipeline steel welds in high-pressure hydrogen environments.
Technical Progress Review and Prospect of Safety Guarantee for Long-Term Service Hydrogenation Reactors
Authors: Xuedong Chen , Zhichao Fan , Jie Dong , Mingdong Hu , Shantung Tu , Cengdian Liu 
Published: October 2021

Abstract
The hydrogenation reactor is the core equipment of petrochemical hydroreforming, hydrorefining, hydrocracking and other units, which operates over long term under harsh conditions, e.g., high temperature, high pressure, hydrogen. In China, a considerable number of hydrogenation reactors have been in service for more than 20 years, and the longest service has reached 48 years. How to ensure the safe operation and reasonably extend the service life of long-term service hydrogenation reactor is an urgent engineering and technical problem. In this paper, the theoretical exploration and empirical research progress on safety guarantee of in-service hot-wall hydrogenation reactors in the past 40 years are reviewed, including failure modes, degradation mechanism of material performance, inspection and maintenance methods, safety assessment and remaining life prediction technologies, welding repair technologies, and improvement of operation process, etc. In view of the main problems existing in the safety guarantee technology of hydrogenation reactors which have been in service for more than 30 years, suggestions for further research are put forward, including establishment of a database for long-term service hydrogenation reactors (20∼50 years), development of high-precision non-destructive testing technology, research on the occurrence, development and termination laws of the potential failure mechanism of long-term service hydrogenation reactors, optimization of safety assessment technology, research on the ultimate service life assessment technology, in order to promote the technical progress of safety guarantee of hydrogenation reactors which have been in service for more than 30 years.
Functional Analysis of a HPHT Subsea Tool Under Thermal Loads
Authors: Bansal Gaurav , Sepehri Ali , Edke Mangesh 
Published: October 2021

Abstract
The offshore oil and gas industry continues to develop new tools that are intended to be operated in increasingly harsh environments. Stricter requirements result in more complex assemblies that are composed of multiple closely fitting components. Fluid flows at high temperatures lead to transient and non-uniform temperature distributions in tools. This can affect tool functionality which needs to be assessed with the help of numerical techniques.
The objective of this study is to evaluate the effect of thermal loads on the functionality of a valve assembly. A thermal finite element model of the assembly is developed to obtain temperature distribution everywhere in the model in transient and steady states. Temperature profiles are later mapped into structural models to obtain thermal strains at critical regions of the assembly. Thermal deformations are evaluated against internal acceptance criteria for operational functionality of the assembly.
Study on Effective Estimation of Parameters of the Herschel-Bulkley Fluid Model for Magnetorheological Fluid
Authors: Keshav Manjeet , C. Sujatha 
Published: October 2021

Abstract
Among different rheological models for Magnetorheological (MR) fluids, Herschel-Bulkley (H-B) fluid model is the most suitable model in explaining the characterization results. The current study presents an effective way for estimating parameters of the H-B model by considering the post-yield low shear rate data to high shear rate data where the shear-thinning effect takes place; this is termed as effective H-B model. For the comparison purpose, the linear Bingham Plastic (BP) model is fitted by projecting high shear rate data onto the y-axis and another H-B model is fitted using all characterization data. To determine the damping forces, formulation for the flow of MR fluid inside the MR valve is presented. The estimated damping forces resulting from the H-B model, BP model and effective H-B model are then compared for different magnetic fields. It was found that the H-B model overestimates the damping forces and, on the other hand, the inability of the BP model in explaining the shear-thinning effects at high shear rates lead to overestimation of damping forces and it becomes more pronounced at high piston velocities. This study may provide guidance for estimating parameters of the H-B model for accurate prediction of damping forces in the design-phase.
Comparison of Classification Machine Learning Algorithms for Damage Detection in Simulated Total Knee Replacements
Authors: Miller Brandon A. , Anton Steven R. 
Published: October 2021

Abstract
Total knee arthroplasty (TKA) is currently one of the most common orthopedic surgeries in the United States. While the surgery is generally highly successful, revision due to pain and failure is costly, and can have adverse impacts on patient outcomes. The possibility exists to reduce rates of catastrophic failure by early detection of damage in total knee replacements (TKR). Previous work has been done to establish the ability of a structural health monitoring (SHM) technique known as the electromechanical impedance (EMI) method to detect certain types of damage prevalent in TKRs. In the previous work, 19 simulated TKRs were constructed and artificially damaged, impedance spectrum measurements were taken, and healthy and damaged data was compared to determine if significant differences between these impedance responses exist. The current study expands upon the previous work by exploring classification machine learning (ML) techniques to translate the differences in impedance responses into discrete damage classes. The goal of this work is to determine ideal classification technique(s) for identifying and classifying damage within the aforementioned TKR systems. To this end, several algorithms are trained on the aforementioned impedance data, and the results of a leave-one-out cross-validation scheme are compared for accuracy, among other common ML performance metrics.
Intraepithelial growth pattern for eyelid sebaceous carcinoma: a cohort of 214 patients from a single institution
Authors: Zhou Chuandi , Chai Peiwei , Xia Wenwen , Li Jiang , Jia Renbing , Fan Xianqun 
Published: October 2021

AimsTo determine the distribution of three different intraepithelial growth patterns (pagetoid, bowenoid and papillary) in eyelid sebaceous carcinoma (SC) and correlate them with the clinical characteristics and prognosis.MethodsA retrospective cohort study. The medical charts and pathological sections were retrospectively reviewed. All eligible patients were followed up for recurrence, metastasis and tumour-related mortality. The clinical significance of each intraepithelial growth pattern was determined by Cox regression.ResultsOf the 214 patients, 67 (31%) presented with intraepithelial invasion, among them, 34 (16%) were pagetoid, 27 (13%) were bowenoid and 6 (2.8%) were papillary. Patients of pagetoid intraepithelial spread showed significantly longer diagnostic delay (p=0.001) and more initial misdiagnoses of blepharitis (p=0.035). After a median follow-up period of 34.0 months, 67 (46%) patients in the non-intraepithelial group, 17 (50%) in the pagetoid group, 8 (30%) in the bowenoid group and 2 (33%) in the papillary group recurred. And 30 (20%) patients in the non-intraepithelial group, 9 (27%) in the pagetoid group and 4 (15%) in the bowenoid group developed metastasis. Moreover, 15 (10%) patients in the non-intraepithelial group, 6 (18%) in the pagetoid group and 1 (3.7%) in the bowenoid group died of SC. Cox regression indicated that pagetoid intraepithelial growth pattern was remarkably associated with increased chances of tumour-related mortality (HR=2.95, 95% CI 1.14 to 7.64, p=0.026).ConclusionsIntraepithelial tumour invasion was presented in nearly one third of patients with eyelid SC. Pagetoid intraepithelial neoplasia, the predominant growth pattern, significantly increased the risk of tumour-related mortality. Meticulous histopathological intraepithelial examination is recommended for every patient of eyelid SC. Special attention should be paid to those with pagetoid invasion, who may require more intensive managements.
Comparison of Different Hydrocolloids on the Novel Development of Muffins from “Purple Yam” (Dioscorea alata) Flour in Sensory, Textural, and Nutritional Aspects
Authors: Gunasekara Dewni , Bulathgama Ashani , Wickramasinghe Indira 
Published: October 2021

Hydrocolloids can act as gluten substitutes to form the structural equivalents of the gluten network in gluten-free bakery products. “Purple yam” (Dioscorea alata) is one of the underutilized yams in Sri Lanka with high nutritional potential. The overall objective of this study was to develop gluten-free muffins using “Purple yam” (Dioscorea alata) flour with hydrocolloids (pectin, xanthan gum, and guar gum) and investigate the nutritional composition and selected properties of the muffins. The texture profiles of gluten-free muffins were analyzed through the following parameters: hardness, adhesiveness, cohesiveness, etc. The chromameter values were obtained and sensory evaluations for gluten-free muffins were carried out. The highest moisture content was recorded in pectin-incorporated muffins (

17.70
±
0.50
%

). The protein content of all three types of muffins was around 5%. The highest fat content was recorded in pectin-incorporated muffins (

19.26
±
0.51
%

). The ash content of all three types of muffins was around 2%. Potassium was the most predominant element found in each muffin. The hardness of guar gum-incorporated muffin (

6379.3
±
135.9

g

) was greater than that of the pectin-incorporated one (

6082.3
±
23.4

g

). Xanthan gum-incorporated muffins had significantly decreased cohesiveness (

0.19
±
0.04

). The highest springiness was obtained in pectin-incorporated muffin (

37.13
±
1.61

mm

). The descending order of the chewiness of muffin is

pectin
−
added
>
xanthan

gum
−
added
>
guar

gum
−
added

sample. According to the sensory evaluation, pectin-incorporated muffin was the best as it had obtained the highest sum of ranks for appearance, color, taste, after taste, and overall acceptability.
ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment
Authors: Dong Feng , Qin Xiaoyang , Wang Baofeng , Li Qian , Hu Jinyang , Cheng Xuan , Guo Dongsheng , Cheng Fangling , Fang Chuan , Tan Yanli , Yan Han , He You , Sun Xiaoyu , Yuan Ye , Liu Hang , Li Ting , Zhao Yingying , Kang Chunsheng , Wu Xudong 
Published: October 2021

Abstract

The dynamic changes of RNA N6-methyl-adenosine (m6A) during cancer progression contribute to quick adaption to microenvironmental changes. Here, we profiled the cancer cell m6A dynamics in the hypoxic tumor niche and its pathological consequences in glioblastoma multiforme (GBM). The m6A demethylase ALKBH5 was induced in GBM models under hypoxic conditions and was associated with a hypoxic gene signature in GBM patient samples. Depletion or inactivation of ALKBH5 in GBM cells significantly suppressed hypoxia-induced tumor-associated macrophage (TAM) recruitment and immunosuppression in allograft tumors. Expression and secretion of CXCL8/IL8 were significantly suppressed in ALKBH5-deficient tumors. However, ALKBH5 did not regulate CXCL8 m6A directly. Instead, hypoxia-induced ALKBH5 erased m6A deposition from the lncRNA NEAT1, stabilizing the transcript and facilitating NEAT1-mediated paraspeckle assembly, which led to relocation of the transcriptional repressor SFPQ from the CXCL8 promoter to paraspeckles and, ultimately, upregulation of CXCL8/IL8 expression. Accordingly, ectopic expression of CXCL8 in ALKBH5-deficient GBM cells partially restored TAM recruitment and tumor progression. Together, this study links hypoxia-induced epitranscriptomic changes to the emergence of an immunosuppressive microenvironment facilitating tumor evasion.

Significance:
Hypoxia induces tumor immune microenvironment remodeling through an ALKBH5-mediated epigenetic and epitranscriptomic mechanism, providing potential immunotherapeutic strategies for treating glioblastoma.
Linking Physical Activity to Breast Cancer: Text Mining Results and a Protocol for Systematically Reviewing Three Potential Mechanistic Pathways
Authors: Lynch Brigid M. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Drummond Ann E. , Swain Christopher T.V. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. 
Published: October 2021

Abstract
Epidemiologic research suggests that physical activity is associated with a reduced risk of breast cancer, but the causal nature of this link is not clear. Investigating mechanistic pathways can provide evidence of biological plausibility and improve causal inference. This project will examine three putative pathways (sex steroid hormones, insulin signaling, and inflammation) in a series of two-stage systematic reviews. Stage 1 used Text Mining for Mechanism Prioritisation (TeMMPo) to identify and prioritize relevant biological intermediates. Stage 2 will systematically review the findings from studies of (i) physical activity and intermediates and (ii) intermediates and breast cancer. Ovid MEDLINE, EMBASE, and SPORTDiscus will be searched using a combination of subject headings and free-text terms. Human intervention and prospective, observational studies will be eligible for inclusion. Meta-analysis will be performed where possible. Risk of bias will be assessed using the Cochrane Collaboration tool, or the ROBINS-I or ROBINS-E tool, depending on study type. Strength of evidence will be assessed using the GRADE system. In addition to synthesizing the mechanistic evidence that links physical activity with breast cancer risk, this project may also identify priority areas for future research and help inform the design and implementation of physical activity interventions.
See related reviews by Swain et al., p. 16 and Drummond et al., p. 28
Cancer-Associated Fibroblast Subpopulations With Diverse and Dynamic Roles in the Tumor Microenvironment
Authors: Simon Thomas , Salhia Bodour 
Published: October 2021

AbstractClose interactions between cancer cells and cancer-associated fibroblasts (CAF) have repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed to show a real benefit in cancer treatment, as preclinical studies have shown that such a strategy can enhance tumor growth. Accordingly, recent paradigm-shifting data suggest that certain CAF subpopulations could also show tumor-inhibitory capabilities. The present review aims to provide an in-depth description of the cellular heterogeneity of the CAF compartment in tumors. Through combining information from different cancer types, here we define 4 main CAF subpopulations that might cohabitate in any tumor microenvironment (TME). In addition, a model for the evolution of CAFs during tumor development is introduced. Moreover, the presence of tumor-inhibitory CAFs in the TME as well as their molecular characteristics are extensively discussed. Finally, the potential cellular origins of these distinct CAF subpopulations are reviewed. To our knowledge, this is the first attempt at establishing a broad but comprehensive classification of CAF subpopulations. Altogether, the present manuscript aims to provide the latest developments and innovative insights that could help refine future therapeutic targeting of CAFs for cancer treatment.
Head and Neck Malignant Paragangliomas: Experience from a Single Institution
Authors: Ding Yiming , Li Lifeng , Han Demin , Wang Shaozhong , Chen Xiaohong 
Published: October 2021

Objectives: To summarize the clinicopathological and genetic features of malignant paragangliomas in head and neck cancer and to explore the appropriate treatment options for this rare lesion. Methods: Six patients harboring head and neck malignant paraganglioma from Beijing Tongren Hospital were retrospectively reviewed. The clinicopathological characteristics, gene mutations, and prognosis of these patients were analyzed. Results: Of these 6 patients, 3 were male and 3 were female; 4 patients harbored malignant carotid body tumors, and two had malignant vagal paragangliomas. Three patients had cervical lymph node metastasis, two presented with lung and bone metastasis, and 1 had lung and liver metastasis. Of the 6 patients, four underwent surgical resection, and the other two patients denied surgery and instead received chemotherapy with paclitaxel, ifosfamide, and dacarbazine. These 2 patients with vagal paraganglioma received postoperative radiotherapy. All 6 patients are still alive at the present time, with a median follow-up time of 66 months. Positive Ki-67 expression in tumor tissue ranged from 1% to 40%. Genetic mutations in SDHD, SDHB, ATR, and MAP3K13 were identified in 4 patients. Conclusions: After comprehensive treatment, head and neck malignant paraganglioma can attain a favorable prognosis. Genetic mutations are commonly detected in patients with malignant paragangliomas. This study also identified mutations in ATR and MAP3K13 in these patients.