bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roles of TAO/TRITON and Argo in tropical Pacific observing system: An OSSE study for multiple time scale variability
Authors: Zhu Jieshun , Vernieres Guillaume , Sluka Travis , Flampouris Stylianos , Kumar Arun , Mehra Avichal , Cronin Meghan F. , Zhang Dongxiao , Wills Samantha , Wang Jiande , Wang Wanqiu 
Published: June 2021

AbstractIn this study, a series of ocean observing system simulation experiments (OSSEs) are conducted in support of the tropical Pacific observing system (TPOS) 2020 Project (TPOS 2020) which was established in 2014, with aims to develop a more sustainable and resilient observing system for the tropical Pacific. The experiments are based on an ocean data assimilation system that is under development at the Joint Center for Satellite Data Assimilation (JCSDA) and the Environmental Modeling Center (EMC)/National Centers for Environmental Prediction (NCEP). The atmospheric forcing and synthetic ocean observations are generated from a nature run, which is based on a modified CFSv2 with a vertical ocean resolution of 1-meter near the ocean surface. To explore the efficacy of TAO/TRITON and Argo observations in TPOS, synthetic ocean temperature and salinity observations were constructed by sampling the nature run following their present distributions. Our experiments include a free run with no “observations” assimilated, and assimilation runs with the TAO/TRITON and Argo synthetic observations assimilated separately or jointly. These experiments were analyzed by comparing their long-term mean states and variabilities at different time scales [i.e., low-frequency (>90 days), intraseasonal (20~90 days), and high-frequency (<20 days)]. It was found that (1) both TAO/TRITON and especially Argo effectively improve the estimation of mean states and low-frequency variations; (2) on the intraseasonal time scale, Argo has more significant improvements than TAO/TRITON (except for regions close to TAO/TRITON sites); (3) on the high-frequency time scale, both TAO/TRITON and Argo have evident deficits (although for TAO/TRITON, limited improvements were present close to TAO/TRITON sites).
Children’s pictures of COVID-19 and measures to mitigate its spread: An international qualitative study
Authors: Bray Lucy , Blake Lucy , Protheroe Jo , Nafria Begonya , de Avila Marla Andreia Garcia , Ångström-Brännström Charlotte , Forsner Maria , Campbell Steve , Ford Karen , Rullander Anna-Clara , Robichaud Fanny , Nolbris Margaretha Jenholt , Saron Holly , Kirton Jennifer A , Carter Bernie 
Published: June 2021

Objectives: To gain insight into children’s health-related knowledge and understanding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and COVID-19, and measures adopted to mitigate transmission. Design: A child-centred qualitative creative element embedded in an online mixed-methods survey of children aged 7–12 years. Setting: Children participated in the study in six countries – the UK, Australia, Sweden, Brazil, Spain and Canada. Method: A qualitative creative component, embedded in an online survey, prompted children to draw and label a picture. Children were recruited via their parents using the researchers’ professional social media accounts, through known contacts, media and websites from health organisations within each country. Analysis of the form and content of the children’s pictures took place. Results: A total of 128 children (mean age 9.2 years) submitted either a hand-drawn ( n = 111) or digitally created ( n = 17) picture. Four main themes were identified which related to children’s health-related knowledge of (1) COVID-19 and how it is transmitted; (2) measures and actions to mitigate transmission; (3) places of safety during the pandemic; and (4) children’s role in mitigating COVID-19 transmission. Conclusion: Children’s pictures indicated a good understanding of the virus, how it spreads and how to mitigate transmission. Children depicted their actions during the pandemic as protecting themselves, their families and wider society.
Successful retreatment with erlotinib after erlotinib-related interstitial lung disease
Authors: Turk Haci M. , Adli Mustafa , Simsek Melih , Aliyev Altay , Besiroglu Mehmet 
Published: June 2021

Background: Epidermal growth factor receptor tyrosine kinase inhibitors are effectively being used in the treatment of non-small cell lung cancer. Although most of their adverse effects are mild to moderate, they occasionally can cause life-threatening interstitial lung disease. We aimed to present a case of lung adenocarcinoma successfully re-treated with erlotinib after recovery with effective treatment of erlotinib-induced interstitial lung disease. Case description: A 54-year-old nonsmoking woman was diagnosed with metastatic adenocarcinoma of the lung. After progression with first-line chemotherapy, erlotinib 150 mg daily was initiated. On the 45th day of erlotinib treatment, interstitial lung disease occurred and erlotinib was discontinued. Clinical improvement was achieved with dexamethasone treatment and erlotinib was re-initiated. Ten weeks after re-initiation of erlotinib, 100 mg daily partial response was observed. Conclusions: Incidence of interstitial lung disease is higher in men, smokers, and patients with pulmonary fibrosis. Interstitial lung disease radiologically causes ground-glass opacity and consolidation. The physician should quickly evaluate new respiratory symptoms in patients treated with epidermal growth factor receptor tyrosine kinase inhibitors, discontinue the epidermal growth factor receptor tyrosine kinase inhibitor treatment, and initiate corticosteroids if clinical diagnosis is interstitial lung disease.
Use of Younger Patient Age and Greater Anterior Center-Edge Angle to Predict the Need for Bilateral Hip Arthroscopy in Patients With Bilateral Femoroacetabular Impingement–Related Hip Pain
Authors: Knapik Derrick M. , Clapp Ian M. , Wichman Daniel , Nho Shane J. 
Published: June 2021

Background: In patients with symptomatic femoroacetabular impingement syndrome, bilateral hip pain has been reported to occur in high frequency. However, not all patients require bilateral hip arthroscopy. Purpose: To determine the incidence, patient-specific variables, and postoperative outcomes in patients who presented with bilateral hip pain at the time of index hip arthroscopy and underwent subsequent contralateral arthroscopic hip surgery. Study Design: Case series; Level of evidence, 4. Methods: Patients who presented with bilateral hip pain, underwent primary hip arthroscopy between January 2012 and June 2018 for indication of femoroacetabular impingement syndrome, and had minimum 2-year follow-up were retrospectively analyzed. Baseline descriptive data, preoperative hip range of motion, and radiographic measurements were recorded with pre- and postoperative patient-reported outcomes (PROs). Independent samples t test was used to compare continuous variables, and chi-square test was used to compare categorical variables between patients undergoing unilateral and bilateral surgery. Bivariate correlations and a multivariable binary logistic regression were performed to determine factors predictive of the need for future contralateral hip arthroscopy. Results: In total, 108 patients were identified who reported bilateral hip pain during the index evaluation, underwent primary hip arthroscopy, and had 2-year follow-up. Among these, 42% (n = 45) elected to undergo hip arthroscopy on the contralateral hip at a mean of 6.0 months (range, 1-17 months) after the index surgery. Patients requiring bilateral surgery were significantly younger ( P = .004) and had a larger preoperative anterior center-edge angle (ACEA; P = .038) when compared with patients who had unilateral surgery. There were no significant differences in alpha angle measurements between patients who had unilateral and bilateral surgery. On bivariate analysis, younger age at the time of the index surgery ( r = −0.272; P = .005) and preoperative ACEA ( r = 0.249; P = .016) were significantly correlated with the need for bilateral surgery. On multivariate analysis, younger age remained a significant predictor for bilateral surgery (odds ratio, 0.95; 95% CI, 0.91-0.99). Patients who underwent bilateral hip arthroscopy reported significant improvement in all PROs ( P < .001), with a significantly greater mean Hip Outcome Score− Sports Specific Subscale score when compared with patients undergoing unilateral surgery ( P = .037). Conclusion: Subsequent contralateral hip arthroscopy was performed in 42% of patients who presented with bilateral hip pain. Younger age at the time of the index surgery and greater ACEA were predictive of the need for contralateral surgery. Patients undergoing bilateral surgery reported significantly improvement in PROs at minimum 2-year follow-up.
Immune thrombocytopenia and COVID-19: Case report and review of literature
Authors: Alonso-Beato Rubén , Morales-Ortega Alejandro , Fernández Francisco Javier De la Hera , Morón Ana Isabel Parejo , Ríos-Fernández Raquel , Rubio José Luis Callejas , Centeno Norberto Ortego 
Published: June 2021

Immune thrombocytopenia, also known as immune thrombocytopenic purpura (ITP), has been reported as an important complication related to COVID-19. We present a 49-year-old male patient with systemic lupus erythematosus with lupus nephritis, antiphospholipid syndrome and history of ITP who developed an ITP flare in the context of COVID-19. He had no bleeding manifestations and had a good response to prednisone treatment. We review the characteristics of the cases reported to date in the literature, with an analysis of 57 patients. Mean age was 56 years (±19.6 SD), and 50.9% were male. This was the first episode of ITP in most of the patients (86.05%), with SARS-CoV-2 acting as the initial trigger. We found that ITP flares may appear in both mild and severe COVID-19 cases. They also appeared at any time during the course of the disease, 48.2% of patients developed it during hospitalization, while it was diagnosed at admission in the rest of the cases. Platelet counts were significantly lower than other ITP series, with a median nadir platelet count of 8 × 109/L (IQR 2–17.75 × 109/L). These patients show a higher bleeding rate (61.4%) compared with other ITP series. They also show a better response to treatment, with good response to the first line therapies in 76.9% of them. The most common first-line treatment was intravenous immunoglobulin (IVIG), used alone or combined with corticosteroids in 40.4% and 32.7% of cases respectively, while 25% of patients received only corticosteroids. Our review suggests that COVID-19-related ITP can be seen even in previously healthy patients. Clinicians must be aware that ITP may appear both in mild and severe COVID-19, at any time during its course. Given that this kind of ITP seems to be associated with a higher bleeding risk, its diagnosis in a clinical scenario such as COVID-19, where anticoagulant therapy is frequently used, may be critical. Treatment with IVIG and/or corticoids is often effective.
Black social workers: Identity, racism, invisibility/hypervisibility at work
Authors: Obasi Chijioke 
Published: June 2021

Summary This article provides a reflexive account of qualitative research with Black female social workers in the North of England. It uses ‘Africanist Sista-hood in Britain’ as the theoretical framework guiding the research. The data are gathered from six semi-structured interviews and two focus groups. Data were analysed via thematic analysis. Participant data are used to discuss issues of identity, race and racism as they contribute to positions of visibility, invisibility and hypervisibility within the social work spaces discussed. The article challenges Western forms of knowledge production as the dominant discourse in social work research, practice, education and training and links this to wider issues of power, privilege and suppression of marginalised voices. Findings The findings section reveals examples of racism, marginality, invisibility and hypervisibility as part of the lived experiences of Black female social workers in the study. It includes discussions of ‘collective strategic projection’ as a consequence of the development of the ‘race taboo’ often present in these work environments. Applications The article calls for social work educators, practitioners and the wider academic field to do more to centralise anti-racist approaches in an attempt to challenge racism in social work.
An intersectional theoretical framework for exploring racialized older immigrant women’s subjectivities
Authors: Syed Manaal 
Published: June 2021

Summary Today, racialized older women’s international migration is increasingly accelerated, cyclical and transnational, illustrating the transcendence of lives across time and space. At the same time, immigration regimes regulate and restrict these seemingly unfettered mobilities using neoliberal, gendered and ageist policies that favor (younger) skilled immigration. This article addresses the question of how social work can use intersectionality perspectives to theorize racialized older immigrant women’s lives which are stretched across multiple time(s) and space(s) yet confined within highly regulated multi-tiered immigration systems. Findings This article outlines a theoretical framework grounded specifically within intersectional feminist, post-structural, and transnational aging perspectives. The framework embraces the temporality, spatiality, and transnationality of gendered, aging and migrant lives and reconsiders their agency as a performed subjectivity bound by multiple forces of institutionalized regimes. Applications This theoretical framework moves social work inquiry to a richer understanding of the migratory realities of diverse aging lives that are simultaneously in-motion and regulated within structural constraints.
Children in domestic violence shelters: Does the feminist perspective collapse?
Authors: Côté Isabelle , Damant Dominique , Lapierre Simon 
Published: June 2021

Summary Even though an extensive body of literature on children has swept the field of domestic violence in the last 30 years, little is known about how domestic violence shelter workers understand children’s situations and how they intervene with them. This article seeks to address this gap in the literature, and presents the results of a study conducted with 48 advocates in the province of Québec (Canada). Findings The data suggest that most of the participants adopt a child-centred perspective and consider the children in their own right during their stay. The accounts of the participants’ practices also reveal that they perceive children as being vulnerable and at-risk. With a moderate emphasis on vulnerability and risk, the participants tend to support the children alongside their mothers, while associating potential risks with the behaviour of the perpetrator of domestic violence. However, with a strong focus on vulnerability and risk, participants tend to cast aside the perpetrators’ behaviour and monitor the women-as-mothers during their stay while associating potential risk with their [in]actions under the circumstances. This can lead to mother-blaming, surveillance and more authoritarian interactions. Applications The understanding of children living with domestic violence needs to remain rooted in a feminist analysis of violence against women in order to avoid some of the issues highlighted in the article. Furthermore, studies that seek to shed light on best social work practices when working with children in alliance with their mothers from a feminist perspective are crucially needed.
Prognostic Factors to Determine Survivorship of Meniscal Allograft Transplant: A Systematic Review
Authors: Wang Ding-yu , Lee Cassandra A. , Li Yan-zhang , Zhang Bo , Li Nan , Jiang Dong , Yu Jia-kuo 
Published: June 2021

Background: There is much room for improvement and optimization of meniscal allograft survivorship. Purpose: To understand prognostic factors for survivorship using evidence-based selection criteria in order to identify patients who would best benefit from meniscal allograft transplant (MAT). Study Design: Systematic review; Level of evidence, 4. Methods: We conducted this systematic review to analyze prognostic factors for survivorship of MAT. The Cochrane Central Register, PubMed publisher, Embase.com , and Web of Science databases were searched through August 8, 2019. Included studies entailed patients of any age who received MAT with a reported association between prognostic factors and survivorship of the allograft. Two reviewers independently screened all titles and abstracts for eligibility, extracted the data, assessed the risk of bias using the Newcastle-Ottawa Scale, and performed a best-evidence synthesis. Results: The review included 18 studies with a total of 1920 patients. The mean follow-up time was 6.0 years (range, 2.1-11.2 years). A total of 20 prognostic factors were identified and shown to be associated with survivorship of MAT. Strong evidence was found that severe cartilage damage was associated with poor survivorship. Strong evidence was also found showing that sex, knee compartment, surgical side, concomitant anterior cruciate ligament (ACL) reconstruction, and concomitant osteotomy for malalignment had no effect on survivorship. Moderate evidence was found that body mass index (<36), tobacco use, and arthroscopic versus open procedure had no influence on survivorship. Conflicting evidence was found that older age and kissing cartilage lesions (lesions on both the femur and tibia vs on a single side) decreased survivorship. Conclusion: Severe cartilage damage decreases the survivorship of MAT. Concomitant ACL reconstruction and osteotomy showed no relationship to survivorship. Many determinants showed conflicting and limited evidence. Older age may be of interest and should be further studied.
Reviewing the link between language abilities and peer relations in children with developmental language disorder: The importance of children’s own perspectives
Authors: Janik Blaskova Lenka , Gibson Jenny L 
Published: June 2021

Background and aims Children with developmental language disorder (DLD) are at risk of difficulties in their friendships and peer relations. The present review explores how research directly involving children with DLD can inform our understanding of peer relations in this group, and how research insights may change according to the nature of their involvement in the studies. We further examine how these findings might shape current theoretical understandings of the links between language impairment and peer relations. Methods An integrative review methodology was used in order to identify relevant studies and synthesise the findings. A structured database search was carried out using the qualitative PICo framework; Population = 4–12-year-old children with DLD, phenomenon of Interest = peer relations, Context = research studies directly including children. After screening, 52 studies were included in a narrative research synthesis. Main contribution: We identified six main types of study that directly included children with DLD; interview, sociometric, self-report, task-based, naturalistic observation and staged observation. Interview-based studies were the most likely to use a meaningful participatory approach. Indications of good practices for participation included reporting on involvement practices, seeking child assent, adapting materials and language used, using visual supports, using child-preferred communication methods and using art-based approaches. Findings from the narrative synthesis of studies highlight the importance of friendships to quality of life, and the role of pragmatic language skills and self-perceptions in building friendships. Conclusions Research on the peer relations of children with DLD is in the early stages when it comes to taking a participatory approach, however there are some examples of inclusive practice from which the whole field can learn. The findings show that research that directly includes children with language disorders and takes account of their communication challenges can help build a more comprehensive knowledge of their world and leads to interesting avenues for interventions targeting social adjustment. Implications: Clinical implications are discussed with reference to the highlighted pragmatic language and social needs of children with DLD, which are typically not addressed unless disproportionately affected in comparison to structural language impairments.
CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant
Authors: Yeh Albert C. , Varelias Antiopi , Reddy Anupama , Barone Sierra M. , Olver Stuart D. , Chilson Kate , Onstad Lynn E. , Ensbey Kathleen S. , Henden Andrea S , Samson Luke , Jaeger Carla A , Bi Timothy , Dahlman Kimberly B. , Kim Tae Kon , Zhang Ping , Degli-Esposti Mariapia A. , Newell Evan W. , Jagasia Madan H. , Irish Jonathan M. , Lee Stephanie J. , Hill Geoffrey R. 
Published: June 2021

Abstract
Donor and recipient cytomegalovirus (CMV) serostatus correlate with transplant-related mortality that is associated with reduced survival following allogeneic stem cell transplant (SCT). Prior epidemiologic studies have suggested that CMV seronegative recipients (R–) receiving a CMV-seropositive graft (D+) experience inferior outcomes compared with other serostatus combinations, an observation that appears independent of viral reactivation. We therefore investigated the hypothesis that prior donor CMV exposure irreversibly modifies immunologic function after SCT. We identified a CD4+/CD57+/CD27– T-cell subset that was differentially expressed between D+ and D– transplants and validated results with 120 patient samples. This T-cell subset represents an average of 2.9% (D–/R–), 18% (D–/R+), 12% (D+/R–), and 19.6% (D+/R+) (P &lt; .0001) of the total CD4+ T-cell compartment and stably persists for at least several years post-SCT. Even in the absence of CMV reactivation post-SCT, D+/R– transplants displayed a significant enrichment of these cells compared with D–/R– transplants (P = .0078). These are effector memory cells (CCR7–/CD45RA+/−) that express T-bet, Eomesodermin, granzyme B, secrete Th1 cytokines, and are enriched in CMV-specific T cells. These cells are associated with decreased T-cell receptor diversity (P &lt; .0001) and reduced proportions of major histocompatibility class (MHC) II expressing classical monocytes (P &lt; .0001), myeloid (P = .024), and plasmacytoid dendritic cells (P = .0014). These data describe a highly expanded CD4+ T-cell population and putative mechanisms by which prior donor or recipient CMV exposure may create a lasting immunologic imprint following SCT, providing a rationale for using D– grafts for R– transplant recipients.