bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erste Fälle des Multisystem Inflammatory Syndrome nach SARS-CoV-2-Infektion bei jungen Erwachsenen in Deutschland
Authors: Rieper Karl , Sturm Andreas 
Published: March 2021

Zusammenfassung
Hintergrund Das seltene Multisystem Inflammatory Syndrome ist bisher bei Kindern als neuartiges Hyperinflammationssyndrom mit Beteiligung verschiedener Organsysteme nach stattgehabter Infektion mit SARS-CoV-2 beschrieben worden. Nachdem bisher vereinzelte Fälle aus Großbritannien und den USA mit „Multisystem Inflammatory Syndrome in Adults“ (MIS-A) beschrieben wurden, werden erstmals 2 Fälle von „Multisystem Inflammatory Syndrome in Adults“ (MIS-A) aus Deutschland vorgestellt, die sich initial zeitgleich und atypisch präsentierten.
Anamnese #1: 27-jähriger Patient mit Fieber bis 40 °C, rechtsseitigen Unterbauchschmerzen und Diarrhöen, Peritonismus. #2: 21-jährige Patientin mit okzipital betonten Kopf- sowie Nackenschmerzen, Somnolenz, Fieber bis 40 °C.
Befunde #1: Es zeigten sich erhöhte Entzündungsparameter und ein erhöhtes Nt-proBNP. Im CT-Abdomen wurden initial Zeichen einer Ileitis terminalis und Kolitis beschrieben. Koloskopisch konnte ein Morbus Crohn ausgeschlossen werden. In der transthorakalen Echokardiografie zeigte sich ein schmaler Perikarderguss ohne hämodynamische Relevanz. Ein SARS-CoV-2-Antikörpertest war positiv. #2: Es zeigten sich erhöhte Entzündungsparameter und ein erhöhtes Nt-proBNP. Die kraniale Computertomografie war unauffällig. Mittels Lumbalpunktion konnte eine Meningitis ausgeschlossen werden. Ein Thorax-CT und eine Abdomen-Sonografie waren ohne pathologischen Befund. In der transthorakalen Echokardiografie zeigte sich eine leichtgradig reduzierte LVEF von 50 %. Ein SARS-CoV-2-Antikörpertest war positiv.
Therapie und Verlauf #1: Eine antibiotische Therapie brachte keine Besserung. Auch eine Prednisolon-Therapie blieb ohne Erfolg. Bei Kreislaufversagen war eine hochdosierte Katecholamin-Therapie notwendig. Erst eine hochdosierte intravenöse Hydrokortison-Therapie brachte eine erhebliche klinische Besserung. #2 Der klinische Zustand verschlechterte sich trotz antibiotischer Therapie. Bei unzureichender klinischer Besserung unter Hydrokortison erfolgte eine hochdosierte intravenöse Immunglobulin-Therapie. Darunter stabilisierte sich der Zustand und die Patientin konnte schließlich beschwerdefrei mit normalisierter LVEF entlassen werden.
Folgerung Das Multisystem Inflammatory Syndrome präsentiert sich als klinisches Chamäleon. Im Rahmen der aktuellen SARS-CoV-2-Pandemie muss mit zunehmenden Fallzahlen auch bei Erwachsenen gerechnet werden. Aufgrund des potenziellen schweren klinischen Verlaufs und möglicher kardialer Beteiligung muss bei Fieber und erhöhten Entzündungswerten der Ausschluss von Differenzialdiagnosen erfolgen und nach Diagnosestellung eine Therapie mit Hydrokortison, ASS und Immunglobulinen evaluiert werden.
Algorithmic Detection of Boolean Logic Errors in Clinical Decision Support Statements
Authors: Wright Adam , Aaron Skye , McCoy Allison B. , El-Kareh Robert , Fort Daniel , Kassakian Steven Z. , Longhurst Christopher A. , Malhotra Sameer , McEvoy Dustin S. , Monsen Craig B. , Schreiber Richard , Weitkamp Asli O. , Willett DuWayne L. , Sittig Dean F. 
Published: March 2021

Abstract
Objective Clinical decision support (CDS) can contribute to quality and safety. Prior work has shown that errors in CDS systems are common and can lead to unintended consequences. Many CDS systems use Boolean logic, which can be difficult for CDS analysts to specify accurately. We set out to determine the prevalence of certain types of Boolean logic errors in CDS statements.
Methods Nine health care organizations extracted Boolean logic statements from their Epic electronic health record (EHR). We developed an open-source software tool, which implemented the Espresso logic minimization algorithm, to identify three classes of logic errors.
Results Participating organizations submitted 260,698 logic statements, of which 44,890 were minimized by Espresso. We found errors in 209 of them. Every participating organization had at least two errors, and all organizations reported that they would act on the feedback.
Discussion An automated algorithm can readily detect specific categories of Boolean CDS logic errors. These errors represent a minority of CDS errors, but very likely require correction to avoid patient safety issues. This process found only a few errors at each site, but the problem appears to be widespread, affecting all participating organizations.
Conclusion Both CDS implementers and EHR vendors should consider implementing similar algorithms as part of the CDS authoring process to reduce the number of errors in their CDS interventions.
Procedural Analgesia in the Neonatal Intensive Care Unit: A Quality Improvement Initiative
Authors: Reddy Sushma , Nesargi Saudamini V. , Stevens Sofia , Jose Jiya , Babu Hindumati 
Published: March 2021

Objective Neonates perceive pain which also has adverse long-term consequences. Newborns experience several painful procedures a day. Various methods of analgesia may be used but are underutilized. The SMART aim of this project was to increase the use of procedural analgesia from 11.5 to 75% in 6 months by using quality improvement principles.
Study Design After a baseline audit, a root cause analysis was done. Based on this, a series of interventions were done as Plan-Do-Study-Act (PDSA) cycles. These included posters on analgesia, display of the pain protocol, orders for analgesia, a written test, small power point presentations on the importance of analgesia, and reminders on the trays used for procedures. At the end of each PDSA cycle, an audit was done to determine the proportion of times analgesia was used. Process indicators were also used when possible. Analysis was done by using the Chi-square test and the paired t-test.
Results At baseline 11% of procedures were done after giving analgesia. This significantly improved to 40% at the end of the first PDSA, and 81% after third PDSA. This was sustained at 75% over the next 2 months.
Conclusion Procedural analgesia can improve and be sustained by using simple interventions.
Key Points
Mixed conductivity analysis of single crystals of α‴-(Cd1−x Znx)3As2 (x = 0.45)
Authors: Zakhvalinskii V. S. , Nikulicheva T. B. , Kochura A. V. , Lahderanta E. , Shakhov M. , Kubankin A. S. , Sukhov M. , Yaprintsev M. N. , Morocho A. A. 
Published: March 2021

We study the conductivity and magnetoresistance of the α‴ phase solid solution of (Cd1−xZnx)3As2 (x = 0.45). Single crystals of (Cd1−xZnx)3As2 are obtained by the modified Bridgman method. The space group and tetragonal lattice parameters of single crystals are found to be I41/amd and a = b = 8.56(5) Å, c = 24.16(6) Å. The temperature dependence of the conductivity and magnetoresistance is studied in the temperature range of 1.6–320 K and in the presence of a transverse magnetic field from 0 to 10 T. Mixed conductivity is analyzed using Hall resistivity data and standard quantitative mobility spectrum analysis. The concentration and mobility of holes are determined at different temperatures. The presence of two types of holes with different mobilities is demonstrated in the temperature range of 1.6–19 K, while with increasing temperature, just one type of charge carrier is observed in the mobility spectrum.
Separation of particles using the focused acoustic sorting chip based on the wettability treatment
Authors: Liu Guojun , Wang Meng , Li Xinbo , Li Yan , Li Pengfei , Li Zhiqiang , Ma Xiang 
Published: March 2021

Combining the focusing energy characteristics of the focused interdigital transducer with the self-cleaning function of the wettability surface, a focused acoustic sorting chip based on the surface wettability treatment is proposed in this work. In the laboratory, two kinds of focused acoustic sorting chips based on the hydrophilic and hydrophobic wall characteristics were designed and fabricated separately. The corresponding separation experiments were carried out using polystyrene microparticles with diameters of 1 and 10 µm. Moreover, the particle adhesion characteristics based on different surface wettability and the effects of average velocity (Va) and input power (P) on particle deflection were investigated. The relevant optimum separation conditions were confirmed, namely under the hydrophilic treatment of the micro-channel surface, when the work frequency (f) was 131.83 MHz, Va = 4 mm/s, and P = 320 mW. Under these conditions, the optimal separation efficiency can reach 99.17%. The proposed chip has the advantages of simple structure, high separation accuracy, self-cleaning, and focusing energy.
Clinicopathological characteristics of lymphoproliferative disorders in 232 patients with rheumatoid arthritis in Japan: A retrospective, multicenter, descriptive study
Authors: Takada Hideto , Kaneko Yuko , Nakano Kazuhisa , Tanaka Masao , Fujii Takao , Saito Kazuyoshi , Sugimoto Naoki , Sasaki Shoh , Saito Shuntaro , Saito Rintaro , Kuramoto Nobuo , Harigai Masayoshi , Suzuki Yasuo 
Published: March 2021

Abstract

Objective
To describe the clinicopathological characteristics of lymphoproliferative disorders (LPDs) in patients with rheumatoid arthritis (RA).

Methods
In this multicenter case series, we retrospectively reviewed the medical records of RA patients who were newly diagnosed as having LPDs with or without biopsy confirmation between 2000 and 2017 in eight hospitals in Japan.

Results
We included 232 patients with LPDs. The median age was 67 years (interquartile range [IQR], 60–73 years), and 77.1% were female. At the time of LPD diagnosis, 94.8% and 62.6% of the patients were methotrexate users and in remission or had low RA disease activity, respectively; lymphadenopathy and extranodal involvement were present in 77.1% and 51.9%, respectively. Major extranodal sites were the lungs and oral/oropharyngeal mucosa. The most common LPD pathological subtype was diffuse large B-cell lymphoma (40.5%), followed by classic Hodgkin lymphoma (10.8%), Epstein–Barr virus-positive mucocutaneous ulcer (7.7%), and reactive lymphoid hyperplasia (6.2%). The clinical and laboratory characteristics varied across the pathological subtypes.

Conclusion
LPD occurred mainly in methotrexate users, while RA disease activity did not seem to be associated with LPD development. Although the clinical manifestations vary among pathological subtypes, manifestations of LPD in patients with RA can include lymphadenopathy, extranodal mass, and mucocutaneous ulcer.
Power spectrum of intrinsic alignments of galaxies in IllustrisTNG
Authors: Shi Jingjing , Kurita Toshiki , Takada Masahiro , Osato Ken , Kobayashi Yosuke , Nishimichi Takahiro 
Published: March 2021

Abstract
We present the 3-dimensional intrinsic alignment power spectra between the projected 2d galaxy shape/spin and the 3d tidal field
across 0.1<k/<60 using cosmological hydrodynamical simulation, Illustris-TNG300, at redshifts ranging from 0.3 to 2. The shape-tidal field alignment increases with galaxy mass and the linear alignment coefficient AIA, defined with respect to the primordial tidal field, is found to have weak redshift dependence. We also show a promising detection of the shape/spin-tidal field alignments for stellar mass limited samples and a weak or almost null signal for star-forming galaxies for the TNG300 volume, ∼ 0.01 (h-1 Gpc)3.
We further study the morphology and environmental dependence of the intrinsic alignment power spectra. The shape of massive disk- and spheroid-galaxies tend to align with the tidal field. The spin of low mass disks (and spheroids at low redshifts) tend to be parallel with the tidal field, while the spin of massive spheroids and disks tend to be perpendicular to tidal field.
The shape and spin of massive centrals align with the tidal field at both small and large scales. Satellites show a radial alignment within the one-halo term region, and low mass satellites have an intriguing alignment signal in the two-halo term region.
We also forecast a feasibility to measure the intrinsic alignment power spectrum for spectroscopic and imaging surveys such as Subaru HSC/PFS and DESI.
Our results thus suggest that galaxy intrinsic alignment can be used as a promising tool for constraining the galaxy formation models.
AOAR: an automatic ocular artifact removal approach for multi-channel electroencephalogram data based on non-negative matrix factorization and empirical mode decomposition
Authors: Gu Yue , Li Xue , Chen Shengyong , Li Xiaoli 
Published: March 2021

Abstract

Objective. Electroencephalogram (EEG) signals suffer inevitable interference from artifacts during the acquisition process. These artifacts make the analysis and interpretation of EEG data difficult. A major source of artifacts in EEGs is ocular activity. Therefore, it is important to remove ocular artifacts before further processing the EEG data. Approach. In this study, an automatic ocular artifact removal (AOAR) method for EEG signals is proposed based on non-negative matrix factorization (NMF) and empirical mode decomposition (EMD). First, the amplitude of EEG data was normalized in order to ensure its non-negativity. Then, the normalized EEG data were decomposed into a set of components using NMF. The components containing ocular artifacts were extracted automatically through the fractal dimension. Subsequently, the temporal activities of these components were adaptively decomposed into some intrinsic mode functions (IMFs) by EMD. The IMFs corresponding to ocular artifacts were removed. Finally, the de-noised EEG data were reconstructed. Main results. The proposed method was tested against seven other methods. In order to assess the effectiveness and reliability of the AOAR method in processing EEG data, experiments on ocular artifact removal were performed using simulated EEG data. Experimental results indicated that the proposed method was superior to the other methods in terms of root mean square error, signal-to-noise ratio (SNR) and correlation coefficient, especially in cases with a lower SNR. To further evaluate the potential applications of the proposed method in real life, the proposed method and others were applied to preprocess real EEG data recorded from children with and without attention-deficit/hyperactivity disorder (ADHD). After artifact rejection, the event-related potential feature was extracted for classification. The AOAR method was best at distinguishing the children with ADHD from the others. Significance. These results indicate that the proposed AOAR method has excellent prospects for removing ocular artifacts from EEG data.
Modes development of PLGA scaffolds modification by magnetron co-sputtering of Cu and Ti targets
Authors: Badaraev A D , Sidelev D V , Yurjev Y N , Bukal V R , Tverdokhlebov S I 
Published: March 2021

Abstract
Bioresorbable scaffolds from poly(lactide-co-glycolide) (PLGA) were formed by electrospinning. Then, plasma modification of PLGA scaffolds was carried out by magnetron co-sputtering of copper and titanium targets in Ar. The surface morphology, elemental composition and mechanical properties of the obtained samples were investigated. The modes of plasma modification were selected that could preserve the macrostructure, morphology and mechanical properties of PLGA scaffolds.
Cathodic arc-PVD Zr-B-Si-C-Ti-(N) coatings
Authors: Blinkov I V , Belov D S , Shestakova V M , Chernogor A V , Yu Kuznetsov B , Laptev A I 
Published: March 2021

Abstract
Arc-PVD coatings Zr-B-Si-C-Ti-N and Zr-B-Si-C-Ti were obtained using combined evaporated ZrB2-SiC-Ti cathodes in a residual atmosphere of N2 and Ar. Their structure and composition were investigated. The Zr-B-Si-C-Ti-N coating has a predominantly amorphous structure, formed mainly on the basis of nitride, carbide, boride phases and complex compounds Zr, Si, Ti. The Zr-B-Si-C-Ti coating is characterized by an amorphous-nanocrystalline structure. The amorphous component of this coating is formed mainly by phases based on Zr and Si. The nanocrystalline structure is formed by a complex carbide (Zr, Ti) C.
Effectiveness enhancement of non-contact vacuum pumps working process
Authors: Burmistrov A , Raykov A , Isaev A , Salikeev S 
Published: March 2021

Abstract
Three options of rotor profiles of Roots vacuum pump are considered: elliptic, circular, and involute. Rotor profiles are drawn in the same housing and are analyzed from point of view of backward leakage minimization through inter-rotor channel and geometric pumping speed increase. It is shown that coefficient of working volume use is only 3% higher for involute profile. Averaged over one revolution conductance of rotor mechanism channels is minimal for elliptic rotor profile. For inter-rotor channel it is 14% less than for involute profile. The presented approach makes it possible to choose the optimal rotor profile of Roots pump for particular purpose.
The effect of nickel on the high-temperature properties of multilayer ceramic coatings
Authors: Chernogor A V , Blinkov I V , Volkhonskiy A O , Sergevnin V S 
Published: March 2021

Abstract
The structure and composition of multicomponent TiCrMoN-Ni arc-PVD coatings with high nickel concentration (more than 8 at.%) are studied at bias potentials of 80-140 V. All coatings are characterized by a layered structure, the modulation period tends to decrease as increasing the bias potential. After annealing at 850 °C in vacuum, the coatings retain their layered structure without signs of dissolution of layers in each other. Nickel sublayers retain their polycrystalline structure, at the same time, the monolayer CrN are formed due to recrystallization.
The large clusters influence on the supersonic flows gas dynamics in a rarefied medium
Authors: Dubrovin K A , Zarvin A E , Yaskin A S , Kalyada V V 
Published: March 2021

Abstract
The processes of Van der Waals clusters formation in supersonic gas flows expanding into a rarefied medium are discussed in this report. The necessary conditions for cluster formation, methods for measuring the average size and size distribution of clusters in a rarefied gas flow are considered. The problems associated with electron-beam ionization of clusters during mass spectrometry of clustered flows are analyzed. The process of intracluster energy exchange in mixtures, that leads to the possibility of inverse pumping of electronic levels of atoms, is illustrated. The problems arising during optical measurements of density in cluster flows are demonstrated. The effect of large clusters formation on the shape and structure of supersonic flows is shown.
Low-temperature formation of boron-containing layers and coatings by electron-ion-plasma method
Authors: Ivanov Yu F , Shugurov V V , Teresov A D , Petrikova E A , Petyukevich M S , Tolkachev O S 
Published: March 2021

AbstractSaturation of the surface of metals and alloys with boron is one of the promising methods for improving the service characteristics of the material. The aim of the present work is to analyze the elemental and phase composition, the state of the defective substructure of the surface layer of high chromium steel, which has been saturated with boron atoms under combined treatment conditions. It has been shown that low-temperature (653 K) ion-plasma borating allows forming a multilayer structure with a total thickness of up to 15 um, containing nano-sized borides of iron and chromium. The hardness of the «film (B)/substrate (AISI 304 steel)» system was increased by 2.2 times relative to the steel in the initial state; hardness of «film (B)/substrate (AISI 310S steel)» system exceeds hardness of initial steel by 1.2 times. The «film (B/W)/substrate (steel)» system is formed and melted with an intense pulsed electron beam. The formation of nanoscale particles of borides and carboborides of iron and chromium was revealed. It is shown that the hardness of the «film (B/W)/substrate (AISI 304 steel)» system after irradiation with an electron beam is 1.5 times lower than the hardness of steel in the initial state; hardness of the «film (B/W)/substrate (AISI steel 310S)» system - 2.3 times.
Identification of defective Pt structure after neutron and ion irradiation
Authors: Ivchenko V A 
Published: March 2021

Abstract
The adequacy of the effect of radiation exposure of different types on the same material (Pt) has been established. For this purpose, radiation defects of one type were studied using field ion microscopy (FIM). The structure of defects was studied on an atomically clean surface and in the near-surface volume of platinum after bombardment with neutrons and ion beams (E > 0.1 MeV and E = 30 keV, respectively). It is shown that the interaction of fast neutrons (E > 0, 1 MeV, F = 6.7 • 1021 m−2, F = 3.5 • 1022 m−2) with platinum leads to certain radiation damage in the volume. The same defects are observed when irradiated with Ar+ ion beams (E = 30 keV, F = 6.7 • 1020 m−2). The latter were found at a depth of about 1.5-2 nm from the irradiated surface. Thus, analog modeling of neutron and ion irradiation with a substance was performed.
Investigation of the effect on power generation level and dynamic characteristics in discharge of carbon dioxide based mixtures
Authors: Kiselev A S , Smirnov E A 
Published: March 2021

Abstract
The article deals with the influence of the power level of the generation of a CO2 laser on its electrical and dynamic characteristics. The dependences obtained will make it possible to take into account the effect of the generation level on the discharge characteristics when calculating the stability of systems for stabilizing the radiation power of gas-discharge lasers.
Method and equipment for forming multilayer intermediate structures in the production of antiemission coatings
Authors: Kostrin D K 
Published: March 2021

Abstract
In the paper the method and equipment for forming antiemission coatings based on platinum and zirconium are described. This method is based on the preliminary formation of a multi-layer complex structure consisting of layers of different compositions, with high-temperature annealing of which it is possible to obtain a high-quality layer of zirconium carbide. Later this layer serves as the basis for obtaining one of the most promising types of anti-emission coatings - Pt3Zr. To implement this method an electronic device with a microprocessor module was developed that allows controlling the pressure in the working chamber, as well as regulating the voltages and currents in the vacuum arc installation.
Study of the texture and residual stresses in multilayer Nb/Mo coatings obtained by inverted magnetrons
Authors: Lozovan A A , Ya Betsofen S , Lenkovets A S , Labutin A A , Kostrin D K , Grushin I A 
Published: March 2021

Abstract
This work is devoted to the study of the formation of the structure, crystallographic texture and residual stresses in multilayer Nb/Mo coatings deposited by inverted magnetrons on a tubular substrate made of a chromium-nickel alloy. Microprobe analysis of the obtained samples did not show the presence of Nb–Mo solid solutions resulting from mutual diffusion, which is most likely caused by low heating of the coating material during deposition. The results of the studies show that in the outer layers of the multilayer coating, residual stresses are characterized by relatively low values. It is likely that the alternation of layers of refractory metals that differ in thermal linear expansion coefficient values leads to mutual compensation of thermal stresses. Thus, the value of the residual stresses of a multilayer coating of any thickness is comparable to a two-layer coating. The texture effect in a multilayer coating is insignificant compared to the effect of solid solution formation, so high-temperature annealing will help to equalize the elastic characteristics and, accordingly, the stress state in the coating.