bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanisms of vasculopathy and coagulopathy in COVID-19
Authors: Al-Gburi Suzan , Beissert Stefan , Günther Claudia 
Published: October 2021

Abstract
COVID-19 primarily affects the respiratory system and may lead to severe systemic complications, such as acute respiratory distress syndrome (ARDS), multiple organ failure, cytokine storm, and thromboembolic events. Depending on the immune status of the affected individual early disease control can be reached by a robust type-I-interferon (type-I-IFN) response restricting viral replication. If type-I-IFN upregulation is impaired, patients develop severe COVID-19 that involves profound alveolitis, endothelitis, complement activation, recruitment of immune cells, as well as immunothrombosis. In patients with proper initial disease control there can be a second flare of type-I-IFN release leading to post-COVID manifestation such as chilblain-like lesions that are characterized by thrombosis of small vessels in addition to an inflammatory infiltrate resembling lupus erythematosus (LE). Mechanistically, SARS-CoV-2 invades pneumocytes and endothelial cells by acting on angiotensin-II-converting enzyme 2 (ACE2). It is hypothesized, that viral uptake might downregulate ACE2 bioavailability and enhance angiotensin-II-derived pro-inflammatory and pro-thrombotic state. Since ACE2 is encoded on the X chromosome these conditions might also be influenced by gender-specific regulation. Taken together, SARS-CoV-2 infection affects the vascular compartment leading to variable thrombogenic or inflammatory response depending on the individual immune response status.
Protein Distribution: Recommendations and Practical Applications for Elite Athletes and Active Adults
Authors: Moore Paul , Krause Alexandra 
Published: October 2021

ABSTRACT
Evenly distributing protein throughout the day is being examined in current research to determine its affect on athletic performance and muscle protein synthesis. Research has suggested that protein amount and timing need to be taken into account to optimize the anabolic window and encourage muscle repair postworkout. This article provides a discussion of muscle protein synthesis, the protein threshold, increasing hypertrophy, the positive performance impact of evenly distributing protein throughout the day, and offers practical applications for these research-based recommendations. This article will help dietitians, strength and conditioning coaches, and others working with elite athletes and/or active adults to make recommendations that are evidence based and related to current research on protein timing and suggested amounts of protein throughout the day.
Performance Profiling in Strength and Conditioning
Authors: Johnson David L. , Bird Matthew D. 
Published: October 2021

ABSTRACT
Performance profiling is a client-led assessment tool that enables athletes to uncover strengths and weaknesses associated with their sporting performance. Initially designed to increase client commitment to a training program, the performance profiling technique presents an opportunity for the athlete to play an active role and contribute to the initial needs analysis process. This evidenced-based method of assessment has been shown to help clients increase their self-awareness, identify areas they can improve, and serve as a basis for goal setting. The tool also permits both client and practitioner to monitor and track progress over time. Although predominantly adopted for those providing psychological support to athletes, the performance profile may be beneficial for strength and conditioning coaches. This article aims to highlight the potential benefits of performance profiling within the field of strength and conditioning, provides guidelines with completed examples for strength and conditioning practitioners to integrate into their work with clients, and presents a brief overview of the theory underpinning the technique.
TSH concentrations in parents and their offspring: a cross-sectional family-based analysis
Authors: Girschik Carolin , Drogge Sophie-Charlotte , Kowall Bernd , Lehmann Nils , Stang Andreas , Zwanziger Denise , Erbel Raimund , Führer Dagmar , Jöckel Karl-Heinz 
Published: October 2021

Objective
Studies that evaluated the genetic influences on thyroid-stimulating hormone (TSH) concentrations were primarily performed in twin cohorts. The aim of this study was to investigate the sex-specific association of serum TSH concentrations between parents and their offspring.

Methods
We used data from the population-based Heinz Nixdorf Recall Study and the associated MultiGeneration Study, including offspring and their biological parents. In 3115 participants (including 1558 offspring from 1138 families), self-reported thyroid diseases and median TSH concentrations depending on thyroid status were assessed. Familial associations of TSH concentrations were investigated in 1485 healthy subjects using linear regression modeling in each group of the parent–offspring relationship using the parent’s TSH concentration as the exposure of interest. To account for the family effect, a mixed‐effects ordinal logistic regression model with random intercept varying at the family level was fitted, using the TSH concentration of the offspring classified into sex- and age-specific quartiles as the outcome.

Results
For every 1 mIU/L increase in the mother’s or father’s TSH concentration, the daughter’s TSH concentration increases by 0.13 mIU/L (95% CI: −0.01; 0.27) and 0.19 mIU/L (0.05; 0.33), respectively, and the son’s TSH concentration increases by 0.13 mIU/L (0.02; 0.25) and 0.20 mIU/L (0.08; 0.32), respectively. Further sensitivity analyses by expanding inclusion criteria and taking family clustering into account corroborated these results.

Conclusions
Serum TSH concentrations of parents are positively associated with those of their offspring in all sex-specific relationships.
Contribuições dos estudos sobre a qualidade ambiental urbana na implementação dos Objetivos de Desenvolvimento Sustentável
Authors: Bezerra Letícia Gabriele da Silva , Silva Márcia Regina Farias da , Grigio Alfredo Marcelo , Pessoa Zoraide Souza 
Published: October 2021

A Agenda 2030 é um plano de ação global, firmado por 193 países durante a realização da Assembleia Geral da Organizações das Nações Unidas – ONU no ano de 2015. A Agenda conta com 17 Objetivos de Desenvolvimento Sustentável – ODS que devem ser efetivados pelos países até o ano de 2030, entre eles, está o ODS 11 – Cidades e comunidades sustentáveis, que foi destacado para realizar uma abordagem mais específica neste estudo, tendo em vista que mais da metade da população mundial já habita os centros urbanos, com previsões para que a mesma praticamente duplique até o final do ano de 2050, tornando a urbanização uma das tendências mais transformadoras deste século. Neste contexto, os estudos sobre a qualidade ambiental podem sinalizar as condições ambientais e urbanas nas cidades, podendo ser articuladas ao ODS 11 em busca do desenvolvimento sustentável nas cidades. Sendo assim, o objetivo deste trabalho foi apresentar e discutir as principais contribuições que os estudos sobre a qualidade ambiental urbana podem oferecer na implementação do ODS 11 – Cidades e comunidades sustentáveis, a partir das pesquisas bibliográfica e documental. Como considerações finais, pode-se inferir que os resultados sobre as condições da qualidade ambiental urbana ao orientarem o planejamento e gestão ambiental urbana, já favorecem o desenvolvimento sustentável as cidades, podendo ainda serem articulados objetivamente ao ODS 11, desde a articulação com suas metas e também com suas recomendações para alcançá-lo, propiciando contribuições a sua implementação e também ao seu acompanhamento.
Диспансеризация населения: ожидания и реальность
Authors: Шейман Игорь Михайлович , Шишкин Сергей Владимирович , Шевский Владимир Ильич , Cажина Светлана Владимировна , Понкратова Оксана Федоровна 
Published: October 2021

Диспансеризации населения позиционируется российским государством как важнейший инструмент политики в сфере здравоохранения. В отчетах органов государственной власти рост охвата населения диспансеризацией и числа выявленных заболеваний представляются как однозначные свидетельства ее успеха. Перспективы ее развития связываются с расширением числа участников и состава мероприятий по выявлению заболеваний. Считается, что это автоматически приведет к улучшению показателей здоровья населения. Между тем связь между профилактикой и показателями здоровья не так однозначна, как это следует из официальных заявлений. В статье рассматривается концептуальная основа реализуемой программы диспансеризации, анализируются реальные практики и результаты ее проведения.Декларируемые цели диспансеризации состоят в максимально широком охвате населения профилактическими мероприятиями и выявлении заболеваний. Анализ практики диспансеризации выполнен по данным онлайн-опроса, проведенного весной 2019 г., 1103 участковых врачей и врачей профилактических подразделений поликлиник, работающих в 81 регионе страны. Результаты опроса показывают, что действия по ведению выявленных в ходе диспансеризации больных, особенно с хроническими заболеваниями, очень ограничены. Почти половина опрошенных врачей не знает о результатах диспансеризации прикрепленного к ним населения; менее 8% считают, что объем последующих мероприятий по диспансерному наблюдению выявленных больных достаточен для полноценного лечения.Результаты опроса и качественных интервью с врачами и руководителями московских поликлиник показали также, что первичное звено здравоохранения еще до пандемии COVID-19 было не готово к проведению эффективного диспансерного наблюдения за  выявленными больными. Более того, диспансеризация обострила дефицит кадров медицинских организаций первичной медико-санитарной помощи. Особенностью программы диспансеризации является централизованная унифицированная модель планирования и проведения ее мероприятий. В ситуации сильного административного давления органов управления здравоохранением всех уровней врачи вынуждены имитировать реальную профилактику как в количественном, так и в качественном отношении. Для повышения медико-экономической эффективности диспансеризации требуются увязка масштабов и содержания ее программы с возможностями первичного звена здравоохранения и ее превращение в комплекс взаимосвязанных мер по выявлению заболеваний и постоянному наблюдению за больными, прежде всего с хроническими заболеваниями.
THE ECONOMIC IMPACT OF THE INTRODUCTION OF DIGITAL TECHNOLOGIES IN THE MINING INDUSTRY
Authors: Evlashkina S. A. 
Published: October 2021

This article discusses the implementation of digital technologies in the mining industry, as well as the economic effect of their implementation. The advantages of using 3D models, “smart ear” systems, “Blast movement technology” are substantiated. It was determined that Industry 4.0 opens up new prospects for the development of the mining industry, creating opportunities for productivity growth with improved labor safety. Thanks to the introduction of geotechnology - Mining 4.0 (Industry 4.0 in the mining industry), including such modern digital technologies as deserted robotic complexes of mining and quarry equipment, ubiquitous digital telemetry, the Internet of Things and machine-to-machine communications, digital 3D modeling and artificial intelligence in the mining industry becomes a high-tech production. The author analyzed the forms of penetration of Industry 4.0 technologies into the mining industries and the international experience of using Mining 4.0, showing the advantages of the further development of geotechnology in a new technological era and the economic effect of their use.
Integrating Effects of Source-Dependent Factors on Sediment-Depth Scaling of Additional Site Amplification to Ground-Motion Prediction Equation
Authors: Wang Hongwei , Li Chunguo , Wen Ruizhi , Ren Yefei 
Published: October 2021

ABSTRACTIt is crucial to include additional site amplification effects resulting from the thick sediment on ground motions in the reliable assessment for seismic hazard in sedimentary basins. Ground-motion residual analysis with respect to ground-motion prediction equation is performed to evaluate additional site amplifications at over 200 K-NET stations within and around Kanto basin. We first investigate the potential effects on additional site amplifications resulted from the sediment depth and several source-dependent factors. Results reveal that source-to-site distance, focal depth, and source azimuth all have nonnegligible effects on additional site amplifications, especially the focal depth. Thick sedimentary sites amplify long-period ground motions from distant earthquakes more strongly than those from local earthquakes. Ground motions from shallow crustal earthquakes generally experience much stronger amplifications than those from those deep subduction earthquakes, much more predominant for long-period ground motions (&gt;1.0 s) at thick sedimentary sites. Meanwhile, we develop the empirical model after integrating contributions from sediment depth, source-to-site distance, and focal depth for predicting additional site amplification effects. Considering the typical case of the distant shallow crustal earthquakes, additional site amplifications at thick sedimentary sites within Kanto basin generally show an increasing trend with the oscillation period increased, whereas they are generally characterized by a decreasing trend at shallow sedimentary sites outside the basin. The mean additional site amplification is up to about 2.0 within Kanto basin, whereas 0.5–0.65 outside Kanto basin, for ground motions at oscillation periods of 2.0–5.0 s. Mean amplifications within Kanto basin are about 3.5 times larger than those outside the basin for long-period ground motions at 2.0–5.0 s. Sites northeast to Kanto basin show the largest amplifications up to about 3.0 at periods of 0.15 and 5.0 s, which may be resulted from the basin edge effects.
Significant bacteriuria among requested repeat urine samples and its clinical correlation
Authors: Bhugra Arjun , Gachinmath Supriya 
Published: October 2021

Background and Objectives: Urinary tract infections (UTI) are the most common bacterial infections in both outpatient and inpatient department received for routine bacterial culture and sensitivity. We looked for significant bacteriuria in re- quested repeat urine sample after primary urine culture yielded significant growth (>105 CFU/ml) of ≥3 types of colonies. Also studied, different isolates grown with their sensitivity pattern and contamination rates of urine samples from different departments.
Materials and Methods: In routine, primary urine cultures yielding ≥3 types of colonies on Cystine Lactose Electrolyte Deficient (C.L.E.D) were requested for repeat samples, collected with aseptic precautions after proper instructions. Data was analyzed for the Microbiological profile and its clinical correlation.
Results: Among 617 received requested urine samples, 292 (47.3%) yielded significant bacteriuria. Clinical details were available for 252 cases out of which 100 (39.7%) showed asymptomatic bacteriuria, 87 (34.5%) complicated UTI and 65 (25.7%) uncomplicated UTI. Null hypothesis was rejected as 292 (47.3%) of the received repeat samples showed significant bacteriuria and 325 (53%) showed normal flora/no growth i.e. there is a 50% chance of getting either a positive culture or normal flora/no growth in repeat urine samples after the primary urine culture showed ≥3 types of colonies. It indicates the importance of requesting repeat urine samples for an accurate urine culture report. Male patients were significantly associ- ated with significant bacteriuria and complicated UTI (p= 0.001). Escherichia coli (n=112, 28%) was the most common fol- lowed by Klebsiella species (n=66, 16.4%) and Enterococcus species (n=69, 17.2%). 183 (45.6%) isolates were Multi-Drug Resistant (MDR) Gram Negative Bacilli (GNBs), Escherichia coli (50.3%) being most common. Vancomycin Resistant Enterococcus (VRE) (n=8, 2.0%) was also isolated.
Conclusion: Our study justifies the rationale for asking a repeat urine samples which helps in providing an appropriate mi- crobiological report with antibiotic sensitivity pattern, hence preventing unwanted reporting of commensals/contaminants facilitating evidence based therapy.
Conhecimento de graduandos em Odontologia sobre diagnóstico e tratamento da cárie dentária
Authors: Martins Caroline Pagani , Thomas Ana Paula , Scaraboto Talita Roberta , Besegato João Felipe , Caldarelli Pablo Guilherme 
Published: October 2021

Esta é uma pesquisa quantitativa, descritiva e transversal, realizada em uma universidade pública em 2018, com o objetivo de avaliar os conhecimentos de estudantes do curso de graduação em Odontologia sobre a cárie dentária. Aplicou-se um questionário para 90 estudantes do 1º; 3º e 5º período. Foi analisado também o Projeto Pedagógico de Curso. Realizou-se análise descritiva e comparativa de proporções por meio do teste Exato de Fisher (p<0.05). Dos pesquisados, 78,9% eram do sexo feminino; 56,7% com 21 a 24 anos, 3,3% tinham 25 anos ou mais. No conhecimento da cárie dentária, foi encontrada diferença estatisticamente significante (p<0.05) ao se comparar a quantidade de erros e acertos entre os três anos avaliados para cinco das dez perguntas. Os resultados mostram diferenças estatísticas para as questões que abordavam o conceito de cárie dentária (1ºano X 3ºano e 3ºano X 5ºano), o papel da saliva no desenvolvimento da doença (1ºano X 3ºano, 1ºano X 5ºano e 3ºano X 5ºano), o diagnóstico de lesão de cárie não cavitada ativa (1ºano X 3ºano e 1ºano X 5ºano), o diagnóstico de lesão de cárie cavitada ativa (1ºano X 3ºano) e o diagnóstico de lesão de cárie cavitada inativa (1ºano X 5ºano e 3ºano X 5ºano). Verificou-se que a estrutura curricular dificulta a integração de conteúdos básicos vinculados à Cariologia e à prática clínica odontológica ao longo da graduação, sendo necessário adequá-la para que os conteúdos relacionados à cárie, de modo que sejam abordados longitudinalmente, integrando os eixos de Ciências Básicas, Ciências Odontológicas e Odontologia em Saúde Coletiva.
ESCOLARIZAÇÃO DE PESSOAS COM DEFICIÊNCIA INTELECTUAL E O ENSINO DE MATEMÁTICA: TEMÁTICAS EMERGENTES PARA A FORMAÇÃO DOCENTE NA PERSPECTIVA DA EDUCAÇÃO INCLUSIVA
Authors: Haas Clarissa , Gechelin Júlia 
Published: October 2021

O artigo aborda o ensino de Matemática para estudantes com deficiência intelectual nos Anos Finais do Ensino Fundamental em uma escola da região serrana do Rio Grande do Sul. A escola selecionada, conforme o Censo Escolar da Educação Básica (2017), apontou a maior matrícula de estudantes com deficiência intelectual na etapa de ensino investigada, dentre as escolas públicas do município. Realizaram-se entrevistas com professoras do Atendimento Educacional Especializado (AEE) e de Matemática. Constatou-se que a deficiência continua sendo vista como intrínseca ao indivíduo. No currículo para o ensino de Matemática prevalece a redução e simplificação dos conteúdos, limitando-se à Matemática básica e às atividades de vida diária. A articulação entre as professoras do AEE e de Matemática não é uma prática regular. Conclui-se que o modo como as professoras concebem a deficiência intelectual interfere na aprendizagem desses estudantes; o planejamento articulado entre os docentes do AEE e área curricular necessita ser uma prática intencional e regular; o currículo no ensino de Matemática deve primar pela acessibilidade curricular para que os estudantes com deficiência intelectual possam participar do projeto pedagógico da turma; há necessidade de novas pesquisas e investimento na formação docente no campo da Educação Matemática e da Educação Inclusiva.
FORMAÇÃO E TRABALHO DOCENTE:
Authors: Filiú de Souza Tania Maria , Brostolin Marta Regina 
Published: October 2021

No entrelaçamento entre formação docente, Educação Infantil e Educação Especial se situa este texto que pretende refletir sobre as condições de formação que os professores da Educação Infantil recebem para trabalharem com crianças com deficiência. Trata-se de um recorte de uma pesquisa de doutorado, de abordagem qualitativa, que utilizou a entrevista semiestruturada e análise documental para a produção de dados. Foi realizada em sete Escolas Municipais de Educação Infantil- EMEIs, de Mato Grosso do Sul, sendo sujeitos da pesquisa oito professores de Educação Infantil que atendem em sala de aula crianças com deficiência. Os resultados evidenciam a necessidade de as instituições formadoras repensarem seus currículos de graduação e pós-graduação referentes a diversidade e desigualdade social, como também uma ação formativa mais significativa da secretaria municipal de educação para a efetivação do trabalho pedagógico. Mas, é importante destacar a recente regulamentação por parte do poder público, o que coloca a Educação Especial em processo de estruturação permeada por conflitos e desafios que repercutem diretamente na vida das crianças.
DERADICALIZATION BASED ON SPIRITUAL NEUROSCIENCE THROUGH ISLAMIC EDUCATION
Authors: Listiana Heni 
Published: October 2021

The development of Islamic Education course materials and deradicalization in learning is one of the efforts to prevent radicalism. Spiritual neuroscience can be used as a tool to study Islamic educational materials and deradicalization. Learning requires neuroscience to know the framework of student’s brain. This article discusses three things: (a) course material related to Islamic education and deradicalization; (b) the abstracted materials from a spiritual neuroscience perspective, and (c) models of Islamic educational material development and deradicalization in spiritual neuroscience. This article shows there are four materials related to Islamic education and deradicalization, they are: the reorientation of the meaning of jihâd, Islâm rahmah li al-‘âlamîn, multicultural values, and the strengthening of the material on love of the mother land. After being analyzed using neurospiritual operators, all such material closely relates to the meaning of life and positive emotions. Thus, Islamic education learning and deradicalization should be able to foster the formation of life meaning and positive emotions in students.
[Pengembangan materi Pendidikan Agama Islam (PAI) dan deradikalasi dalam pembelajaran merupakan salah satu upaya tindakan pencegahan tindakan radikalisme. Neurosains spiritual dapat dijadikan sebagai alat untuk menelaah materi-materi Pendidikan Agama Islam (PAI) dan deradikalisasi. Pembelajaran membutuhkan neurosains untuk mengetahui kerangkan kerja otak siswa. Artikel ini membahas tiga hal: (a) materi yang berkaitan dengan Pendidikan Agama Islam (PAI) dan deradikalisasi; (b) materi-materi yang tersarikan akan dikaji dalam perspektif neurosains spiritual; dan (c) model pengembangan materi Pendidikan Agama Islam (PAI) dan deradikalisasi dalam neurosains spiritual. Artikel ini menunjukkan ada empat materi yang berkaitan dengan Pendidikan Agama Islam (PAI) dan deradikalisasi yaitu reorientasi makna jihad, Islâm rahmah li al-‘âlamîn, nilai-nilai multikultural, dan penguatan materi cinta tanah air. Setelah dianalisis dengan menggunakan operator neurospiritual semua materi tersebut berkaitan erat dengan makna hidup dan emosi positif. Dengan demikian pembelajaran Pendidikan Agama Islam (PAI) dan deradikalisasi harus mampu menumbuhkan terbentuknya makna hidup dan emosi positif pada diri siswa]