bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Curcumin for Wound Repair in Diabetic Rats/Mice: A Systematic Review and Meta-analysis of Preclinical Studies
Authors: Li Yuan , Zhao Sheng , der Merwe Leanne Van , Dai Wentong , Lin Cai 
Published: June 2021

Background:
Curcumin possesses multiple bioactivities that have beneficial effects on diabetic foot
ulcers. Herein, we aimed to conduct a preclinical systematic review of 9 studies, including a total of 262 animals,
to assess the possible mechanisms of curcumin for wound healing in diabetic animals.

Methods:
Five databases were searched from inception to May 12, 2020; Rev-Man 5.3 software was applied
for data analyses. Cochrane Collaboration’s tool 10-item checklist was used to evaluate the methodological
quality, and data revealed scores of risk of bias ranging from 2 to 5.

Results:
Meta-analysis indicated that curcumin had significant effects on wound healing rate and blood vessel
density when compared with control (P < 0.05). The wound regeneration properties of curcumin for diabetic
wounds are thought to mainly work through the possible mechanisms of antioxidation, enhanced cell proliferation,
increased collagen formation, and angiogenesis. However, the anti-inflammatory effect on wounds in diabetic
animals remain controversial.

Conclusions:
The findings indicate that more randomized controlled trials should be pursued to obtain more reliable
results regarding inflammatory response. Overall, curcumin might be a probable candidate for diabetic
foot ulcers and may contribute to future clinical trials.

Prospero Registration:
CRD42020188981.
Facile and Novel Synthesis of Spiky Gold Nanoparticles as an Efficient
Antimicrobial Agent against Pseudomonas Aeruginosa
Authors: Imran Muhammad , Aziz Farooq , Rashid Muhammad , Rehman Mubashar , Rafique Muhammad 
Published: June 2021

Aims:
The study aims to develop advanced antibacterial agents as nanoparticles instead of antibiotics due to the emergence of antimicrobial resistance.

Background:
Pseudomonas aeruginosa is capable of causing many diseases, including severe bacterial pneumonia. There is a need for an efficient antibacterial agent to kill these pathogens.

Objective:
The objective of the study is to synthesize advanced antibacterial agents as nanoparticles for biomedical applications that can play a vital role in killing Gram-negative bacteria (Pseudomonas aeruginosa).

Method:
A novel fabricated growth of hydrophilic spiky gold nanoparticles (SGNPs) via reduction method is reported.

Results:
The surface plasmon resonance peak of the synthesized SGNPs was tuned under the near-infrared range. The SGNPs have anisotropic and spiky morphology with 68 nm size and -58 mV surface charge. They are pure, possessing adsorption similar to the organic material. Pseudomonas aeruginosa treated with synthesized SGNPs showed 60% bacterial death at the concentration of 100 μM.

Conclusion:
This work consists of the novel synthesis of SGNPs via a safe and simple reduction method. The synthesized SGNPs exhibit strong antibacterial activity against the Gram-negative bacteria Pseudomonas aeruginosa measured using a microplate assay test. The result showed that these SGNPs are ideal for biomedical applications.
Long-Lasting In Situ Forming Implant Loaded with Bupivacaine: Investigation
on Polymeric and Non-Polymeric Carrier and Solvent Effect
Authors: Mobedi Hamid , Bazraee Saeed , Mashak Arezuo , Jamshidi Ahmad 
Published: June 2021

Introduction:
Typically, in situ forming implants utilize Poly (lactide- co- glycolide)
(PLGA) as carrier and N-methyl-2-pyrrolidone (NMP) as solvent. However, it is essential to develop
different carriers to release various drugs in a controlled and sustained manner with economic
and safety considerations.

Objective:
The present study aims to evaluate the in-vitro release of Bupivacaine HCl from in situ
forming systems as post-operative local anesthesia.

Methods:
We used Sucrose acetate isobutyrate (SAIB), PLGA 50:50, and a mixture of them as carriers
to compare the release behavior. Besides, the effect of PLGA molecular weight (RG 502H,
RG 503H, and RG 504H), solvent type, and solvent concentration on the drug release profile has
been evaluated. The formulations were characterized by investigating their in-vitro drug release,
rheological properties, solubility, and DSC, in addition to their morphological properties. Furthermore,
the Korsmeyer-Peppas and Weibull models were applied to the experimental data. Results revealed
that using a mixture of SAIB and PLGA compared to using them solely can extend the Bupivacaine
HCl release from 3 days to two weeks.

Results:
The DSC results demonstrated the compatibility of the mixture by showing a single Tg.
The formulation with NMP exhibited a higher burst release and final release in comparison with
other solvents by 30% and 96%, respectively. Increasing the solvent concentration from 12% to
32% raised the drug release significantly, which confirmed the larger porosity in the morphology
results. From the Korsmeyer-Peppas model, the mechanism of drug release has been predicted to
be non-Fickian diffusion.
Dapsone, More than an Effective Neuro and Cytoprotective Drug
Authors: Diaz-Ruiz Araceli , Nader-Kawachi Juan , Calderón-Estrella Francisco , Mata- Bermudez Alfonso , Alvarez-Mejia Laura , Ríos Camilo 
Published: June 2021

Background:Dapsone (4,4'-diamino-diphenyl sulfone) is a synthetic derivative of sulfones, with the antimicrobial activity described since 1937. It is also a drug traditionally used in dermatological therapies due to its anti-inflammatory effect. In recent years its antioxidant, antiexcitotoxic, and antiapoptotic effects have been described in different ischemic damage models, traumatic damage, and models of neurodegenerative diseases, such as Parkinson's (PD) and Alzheimer's diseases (AD). Finally, dapsone has proven to be a safe and effective drug as a protector against heart, renal and pulmonary cells damage; that is why it is now employed in clinical trials with patients as a neuroprotective therapy by regulating the main mechanisms of damage that lead to cell death.Objective:To provide a descriptive review of the evidence demonstrating the safety and therapeutic benefit of dapsone treatment, evaluated in animal studies and various human clinical trials.Methods:We conducted a review of PubMed databases looking for scientific research in animals and humans, oriented to demonstrate the effect of dapsone on regulating and reducing the main mechanisms of damage that lead to cell death.Conclusion:The evidence presented in this review shows that dapsone is a safe and effective neuro and cytoprotective treatment that should be considered for translational therapy.
Characterization of Bioactive Compounds from the Red Sea Tunicate-
Derived Fungus Penicillium commune DY004
Authors: Youssef Diaa T.A. , Shaala Lamiaa A. , Almohammadi Ameen , Elhady Sameh S. , Alzughaibi Torki A. , Alshali Khalid Z. 
Published: June 2021

Abstract:
As a part of our ongoing interest to identify bioactive microbial secondary metabolites,
the Red Sea tunicate derived Penicillium commune DY004 was investigated. A new dipeptide,
penicillizine A (1) together with cyclo(L-Pro-L-Phe) (2), meleagrin (3), α-cyclopiazonic acid (4)
and N-(4-hydroxyphenethyl)acetamide (5) was isolated from the ethyl acetate extract of the cultures
of the fungus. The structural determinations of 1-5 were supported by interpretation of their
one- and two-dimensional nuclear magnetic resonance (NMR) and mass spectrometry (MS) data.
In the evaluation of the compounds for their effects against three human tumorous cell lines, meleagrin
(3) and α-cyclopiazonic acid (4) displayed the highest and potent activity against HeLa,
U373 glioblastoma and MDA-MB-231 cell lines down up to 3.1 μg/mL. These results suggest
that marine fungi are a copious source of drug leads with therapeutic potential. Meleagrin and α-
cyclopiazonic acid could be used as potential scaffolds for the development of new and more effective
drug leads.
The Effectiveness of the “Panjang” Poffertjes Consumption on Blood Glucose Level
Authors: Talibo Sofyawati D. , Tumenggung Imran , Nawai Fatmayanti , Labatjo Rahma 
Published: June 2021

Background:
Fragrant pandan leaf extract (Pandanus amayllifolius Roxb.) has pharmacological
activity as an anti-diabetes, while sweet corn is believed to be a staple food or snack for
people with diabetes mellitus. Thus, the foods could be used as an alternative to anti-diabetic functional
food.

Objective:
This study aims to investigate the effectiveness of “Panjang” poffertjes consumption
with the addition of pandan leaves extract and sweet corn on the blood glucose level.

Methods:
This study employs a randomized controlled trial approach with the pre-and post-test
design. The data collected on the value of the glycemic index, glycemic load, and the results of 2
hours postprandial (pp) blood sugar level examination after consuming two Poffertjes formulas.
The glycemic index (GI) was calculated by employing incremental area under the blood glucose
response curve method for ten subjects and a 2-hour postprandial (pp) blood sugar level examination
in 25 subjects with the range age between 18-24 years, with normal nutritional status (BMI =
18.58-23.88), 100% had no history of diabetes, did not smoke or alcohol and were not allergic to
the tested food ingredients.

Results:
the results show that the glycemic index of control Poffertjes obtained a value of 71.88
(high category), and “Panjang” Poffertjes got 52.82 (low category). The glycemic load of control
Poffertjes obtained a value of 12.78 (medium category), while “Panjang” Poffertjes attained a
value of 6.37 (low category). The difference in the average reduction in blood glucose with the
intervention poffertjes was 11.08 mg/dl.

Conclusion:
the provision of “Panjang” poffertjes has a significant effect on the decrease in twohour
postprandial blood glucose level.
Photoresponsive Delivery of Nanovectors: A Review of Concepts and Applications
Authors: Lalan Manisha , Menon Maanika , Shah Pranav 
Published: June 2021

:
Stimuli-triggered nanovectors for drug delivery enhance the clinical efficacy and decrease
the toxicity by specifically conveying the drugs to the site of target with a higher specificity and efficiency.
Several stimuli were regarded, but light as an exogenous stimulus tenders several benefits in
clinical usage like elevated spatial and temporal control economically. A number of photochemical
mechanisms have been exploited in design of phototriggered nanocarriers for biomedical applications.
Light in conjugation with photosensitizers or imaging agents in nanovectors can be truly rewarding
to ensure precise diagnosis, drug delivery and improve therapeutic outcomes. Nanomedicine
plays a key role in enhancing therapeutic efficacy and limiting the adverse effects. The review evaluates
the multiple nanocarriers such as liposomes, polymersomes, micelles, nanogels etc., which have
leveraged the advantages of phototargeting via photothermal, photochemical, photo isomerization
and upconversion based activation strategies for efficient drug targeting to intracellular and other
regions. The significant benefits and constraints, an overview of the implementation and latest developments
for the most popular and recent photoresponsive drug delivery methods are discussed to
critically judge its success and limitations and delve upon the possible future perspectives in the
field.
Significance of Patient Safety and Safety Culture in Dental Schools: A Systematic Review
Authors: Abutayyem Huda , M Lovely , Luke Alexander , Khan Yawar Hayat , Muhammad Muhammad , George Biji Thomas 
Published: June 2021

Objectives:
This article aims to systematically review and analyze the outcome of published literature on patient safety and safety culture related to dental schools. It also aims to observe implemented changes in dental school training and curriculum that have improved patient safety and safety culture within institutions.

Methods:
All studies concerning patient safety and safety culture from the period of January 2010 to May 2020 were included which were specific to dental educational institution settings. The assessment was based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) checklist to ascertain that the included studies were specific to the objective of our systematic review.

Results:
The included studies were assessed for country-wise publication, type of study, and its outcome. Of the 10 studies that met the inclusion criteria, 5 articles were related to patient safety. 2 out of the 5 articles were from the United States of America (USA) 2 were from the United Kingdom (UK), followed by 1 from Mexico. For articles related to safety culture, 3 out of the 5 articles were from Saudi Arabia, and 2 were from the USA.

Conclusion:

The analysis of the selected review articles suggests that rigorous training should be implemented in inpatient record documentation, incident reporting, and infection control protocols. The authors suggested focused training on patient safety culture and the inclusion of safety culture awareness and training to the dental undergraduate curriculum.
Client-Driven Level 2 BIM Implementation: A Case Study from the UAE
Authors: Shafiq Muhammad T. 
Published: June 2021

Background:
Implementation of Building Information Modelling (BIM) has proven to deliver major performance improvements in Program efficiency, design quality, constructability, waste reduction, environmental performance, and capital & operational cost management of built environment projects. Yet BIM implementation in low BIM maturity markets, such as the UAE, is limited to technology applications which fail to deliver the full potential of BIM benefits to client originations.

Objective:
The purpose of this paper is to investigate BIM implementation from a client’s perspective and to present a case study that exhibits a level 2 BIM implementation process in a traditional procurement environment.

Methods:
The study has used a case study approach combined with a literature review. A critical appraisal of relevant literature is presented to highlight key issues hindering BIM implementation for client organizations, especially in developing BIM markets, such as the UAE. The research is collected using an action research approach within a case study, including project document audit, participation in project collaboration meetings and extensive communication with the project stakeholders. The case study is presented in a practice-oriented research format describing the project details, procurement approach, BIM development & management process and benefits achieved for the project client.

Results:
The paper presents a structured approach to strategically introduce BIM within a low BIM maturity market, creating partnering relationships, empower the supply chain partners and achieving significant BIM benefits with minimum disruption to existing work practices. The paper highlights that although BIM requires a step-change in the work practices of the construction industry, yet it is possible to successfully implement BIM with traditional procurement settings, which may be a critical feature in a certain market or a client requirement.

Conclusion:
There is a need for case study based, practice-oriented research work within the domain of BIM implementation. Construction clients in low maturity BIM markets are concerned about the perceived benefits of BIM and its practical implementation within existing business practices, which is addressed in this paper. Overall, the findings of this study are useful for construction industry clients and academia in redefining the existing work practices to incorporate BIM-enabled processes and applications.
The Knowledge of Female Students Regarding the Human Papilloma Virus and Vaccines at a Selected University in South Africa
Authors: Mushasha Matodzi P. , Mashau Ntsieni S. , Ramathuba Dorah U. 
Published: June 2021

Background:
The Human Papillomavirus (HPV) is one of the viruses that causes high mortality rates worldwide, and if not detected and treated early, it may lead to fatal complications such as cervical cancer and breast cancer.

Purpose:
The aim of this study was to determine the knowledge of female students regarding the Human Papillomavirus (HPV) and its vaccines at a selected University in the Limpopo Province, South Africa.

Methods:
A quantitative approach was adopted in this cross-sectional descriptive study. The target population was all female students residing in the university residences on campus, and a sample size of 310 students was determined. A systematic sampling technique was used to select the rooms of students, and a self-administered questionnaire was used to collect data. Data collected was analysed using SPSS version 26, and results were presented in the form of frequency and percentages.

Results:
Out of the 310 respondents, 56.8% had never heard about the HPV, while 43.2% had heard about the HPV and its vaccines. The majority (82.9%) of the respondents were uncertain about the two HPV vaccines available in South Africa, while only 1.9% of the respondents knew that anal cancer is one of the health problems related to HPV. The results of the study further showed that 56.8% of the respondents did not know whether the HPV vaccines prevented cervical cancer or not, while only 6.1% disagreed that the HPV vaccines prevented cervical cancer.

Conclusion:
The study concludes that the female students at the selected university had insufficient knowledge regarding HPV and its vaccines. Since cervical cancer is one of the major causes of death in low and middle-income countries, knowledge regarding HPV and its vaccines is crucial, especially among the young generation, in order to promote the effective prevention of cervical cancer. Community and university radios should have programs about health promotion issues informing the communities about HPV and its vaccines.
Green Synthesis of Antibacterial Silver Nanoparticles against Drug Resistant Bacteria
Authors: Siddiqui Ayesha , Shakoor Afnan Abdul , Zohra Rashida Rahmat , Ahmad Mahnaz , Zohra Raheela Rahmat 
Published: June 2021

Background:
Nanotechnology brings a massive revolution in the domain of medical
biotechnology. Plants possess thousands of antimicrobial compounds; these compounds can be extracted
and utilized in the production of medicines.

Objective:
The aim of this research is to design an economical method for the formation of nanoparticles
from plants and explore their antibacterial activity.

Methods:
In the present study, we used the plants Aloe barbadensis, Azadirachta indica, Carica papaya,
Mentha arvensis and Catharanthus roseus. Ethanolic, methanolic and aqueous extracts of the
above mentioned plants were used to prepare silver nanoparticles. Antimicrobial activities of the
nanoparticles of extracts were determined against pathogenic strains of bacteria.

Results:
Results showed that silver nanoparticles are formed from the ethanolic and methanolic extracts
of Azadirachta indica, Carica papaya, Mentha arvensis and Catharanthus roseus and from
the aqueous extracts of Aloe barbadensis and Mentha arvensis. It was observed that nanonoparticles
of ethanolic extracts of Azadirachta indica, Carica papaya, Mentha arvensis and Catharanthus
roseus exhibited the highest antibacterial activity against Pseudomonas specie, E.coli, Pseudomonas
specie and S.typhi, respectively. On the other hand, the nanoparticles of methanolic extracts
of Carica papaya, Mentha arvensis and Catharanthus roseus showed the highest inhibition against
E.coli, whereas, maximum zone of inhibition of Pseudomonas was observed by the action of
methanolic extract of Azadirachta indica. It is also found that nanoparticles of the aqueous extracts
of Aloe barbadensis and Mentha arvensis inhibited the pathogenic strains and showed maximum
activity against Pseudomonas and E.coli, respectively.

Conclusion:
The above results indicate that the nanoparticles formed from the extracts of the tested
plants have high antimicrobial potential and could be utilized in the preparation of medicines to
treat various disorders.
A Non-intrusive Load Identification Algorithm Combined with Event Detection
Authors: Jiao Runhai , Zhou Qihang , Lyu Liangqiu , Yan Guangwei 
Published: June 2021

Background:
The traditional state-based non-intrusive load monitoring method mainly
deploys the aggregate load as the characteristic to identify the states of every electrical appliance. Each
identification is relatively independent, and there is no correlation between the identification results.

Objective:
This paper combines the event detection results with the state-based non-intrusive load
identification algorithm to improve accuracy.

Methods:
Firstly, the load recognition model based on an artificial neural network is constructed, and
the state-based recognition results are obtained. An event recognition and detection model is then
built to identify electrical state transitions, that is, the current moment based on the event recognition
results obtained from the previous moment. Finally, a reasonable decision method is constructed to
determine the identification result of the electrical states.

Result:
Experimental results on the public data set REDD show that in the Long Short-Term
Memory (LSTM) fusion model, the macro-F1 is increased by an average of 6%, and the macro-F1 of
the Artificial Neural Network (ANN) fusion model is increased by an average of 5.3% compared with
LSTM and ANN.

Conclusion:
The proposed model can effectively improve the accuracy of identification compared
with the state-based load identification method.
Pyrazole Substituted 9-Anilinoacridines as HER2 Inhibitors Targeting
Breast Cancer - An in-silico approach
Authors: Rajagopal Kalirajan , Sri Vulsi Bodhya , Byran Gowramma , Gomathi Swaminathan 
Published: June 2021

Background:
Breast cancer is one of the malignant tumours which mainly affect the female
population. 20% of the cases of breast cancer are due to the over-expression of Human epidermal
growth factor receptor-2 (HER2), which is the dominant tyrosine kinase receptor. In general,
9-anilinoacridine derivatives play an important role in antitumor activity due to their DNA-intercalating
properties.

Objective:
Some novel 9-anilinoacridines substituted with pyrazole moiety (1a-z) were designed
and their HER2enzyme (PDB id-3PP0) inhibition activity was performed by molecular docking
studies using the Glide module of Schrodinger suite 2019-4.

Methods:
Glide module of the Schrodinger suite was used to perform docking studies; qikprop module
was used for in-silico ADMET screening and the Prime-MMGBSA module was used for free
binding energy calculations. Based on GLIDE scoring functions, we can determine the binding
affinity of ligands (1a-z) towards HER2.

Results:
The inhibitory activity of ligands against HER2 was mainly due to the strong hydrophobic
and hydrogen bonding interactions. Almost all the compounds 1a-z exhibited a good binding affinity
with Glide scores in the range of -4.9 to -9.75, when compared with the standard drugs CK0403
(-4.105) and Tamoxifen (-3.78). From the results of in-silico ADMET properties, it was evident
that most of the compounds fell within the recommended values. MM-GBSA binding calculations
of the most potent inhibitors were found to be more favourable.

Conclusion:
The results of in-silico studies provide strong evidence for the potential of valuable ligands
in pyrazole substituted 9-anilinoacridines as HER2 inhibitors, and the compounds,
1v,s,r,d,a,o with significant Glide scores may produce significant anti-breast cancer activity.