bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intake of micronutrients and fatty acids of vegetarian, vegan, and omnivorous children (1–3 years) in Germany (VeChi Diet Study)
Authors: Weder Stine , Keller Markus , Fischer Morwenna , Becker Katja , Alexy Ute 
Published: December 2021

Abstract
Purpose
There is an ongoing debate whether vegetarian (VG) and especially vegan (VN) diets are nutritionally adequate in early childhood. Hence, the Vegetarian and Vegan Children Study (VeChi Diet Study) aimed to assess the food and nutrient intake of VG and VN infants.

Methods
The study examined the diets of 1–3-year-old VG, VN, and omnivorous (OM) children (n = 430). Dietary intake was assessed via a 3-day weighed dietary record and compared between groups using ANCOVA. Lifestyle data were collected using a questionnaire. Here, the results of micronutrient and fatty acid intakes are presented.

Results
Most nutrient intakes (with and without supplements) differed significantly between VN children and the two other groups, with a more favourable overall micronutrient intake in VN, followed by VG children, [e.g., the highest intake of vitamin E (8.3 mg/d vs. VG 7.4 mg/d and OM 5.1 mg/d), vitamin B1 (569 µg/d vs. VG 513 µg/d and OM 481 µg/d), folate (143 µg/d vs. VG 116 µg/d and OM 108 µg/d), magnesium (241 mg/d vs. VG 188 mg/d and OM 164 mg/d), and iron (8.9 mg/d vs. VG 7.3 mg/d and OM 6.0 mg/d)] as well as fat quality [highest intake of polyunsaturated fatty acids (8.7 E% vs. VG 6.9 E% and OM 4.5 E%) and lowest intake of saturated fatty acids (9.1 E% vs. VG 11.9 E% and OM 14.0 E%)]. In contrast, OM children had the highest intake of vitamin B2 (639 µg/d vs. VG 461 µg/d and VN 429 µg/d), calcium (445 mg/d vs. VG 399 mg/d and VN 320 mg/d), iodine (47 µg/d vs. VG 33 µg/d and VN 31 µg/d), and DHA (35.4 mg/d vs. VG 16.6 mg/d and VN 18.4 mg/d). Without supplementation, OM children had the highest average vitamin B12 intake (1.5 µg/d vs. VG 0.6 µg/d and VN 0.2 µg/d), whereas VN children had the highest average vitamin B12 intake with supplementation (73.8 µg/d vs. VG 1.3 µg/d and OM 1.7 µg/d). Without supplementation, none of the groups’ median intakes met the harmonised Average Requirement (h-AR) for vitamin D and iodine. Moreover, VG and VN children did not achieve h-ARs for vitamin B2, vitamin B12, and iron—if a low absorption of iron is anticipated; VN children also did not do so for calcium.

Conclusion
In early childhood, VN and VG diets can provide most micronutrients in desirable amounts and a preferable fat quality compared to an OM diet. Special focus should be paid to (potentially) critical nutrients, particularly vitamin D, iodine, and DHA for all children regardless of diet, as well as vitamin B2, vitamin B12, calcium, and iron for VG and VN children.

Trail registration
This study was registered with the German Clinical Trials Register (DRKS00010982) on (September 2, 2016).
Investigation of the well-dispersed magnetorheological oil-based suspension with superparamagnetic nanoparticles using modified split Hopkinson pressure bar
Authors: Osial Magdalena , Nowicki Michał , Klejman Ewa , Frąś Leszek 
Published: December 2021

AbstractMagnetorheological (MR) fluids are classified as smart materials whose viscoplastic characteristics change under the magnetic field. They are widely applied for dynamic energy dissipation due to their rapid thickening under the external magnetic field. In this work, the core–shell suspension of superparamagnetic iron oxide-based nanoparticles was synthesized and dispersed in silicone oil. Much effort has been made to prepare suspension meeting requirements of MR fluid. The experimental squeezing flow response was studied using a modified split Hopkinson pressure bar (SHPB) with various shear rates. Tests with modified SHPB show that MR fluid rapidly responds to the compression thickening and forming chain-like structures. MR fluid dissipates the energy generated during compression stress tests. This study presents a simple and cost-effective synthesis way suitable for MR fluid formation for its dynamic energy dissipation application.
Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation
Authors: Longchamps R. J. , Yang S. Y. , Castellani C. A. , Shi W. , Lane J. , Grove M. L. , Bartz T. M. , Sarnowski C. , Liu C. , Burrows K. , Guyatt A. L. , Gaunt T. R. , Kacprowski T. , Yang J. , De Jager P. L. , Yu L. , Bergman A. , Xia R. , Fornage M. , Feitosa M. F. , Wojczynski M. K. , Kraja A. T. , Province M. A. , Amin N. , Rivadeneira F. , Tiemeier H. , Uitterlinden A. G. , Broer L. , Van Meurs J. B. J. , Van Duijn C. M. , Raffield L. M. , Lange L. , Rich S. S. , Lemaitre R. N. , Goodarzi M. O. , Sitlani C. M. , Mak A. C. Y. , Bennett D. A. , Rodriguez S. , Murabito J. M. , Lunetta K. L. , Sotoodehnia N. , Atzmon G. , Ye K. , Barzilai N. , Brody J. A. , Psaty B. M. , Taylor K. D. , Rotter J. I. , Boerwinkle E. , Pankratz N. , Arking D. E. 
Published: December 2021

AbstractMitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify genes involved in regulating mitochondrial function, we performed a genome-wide association study (GWAS) in 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (UKB). We identified 133 SNPs with statistically significant, independent effects associated with mtDNA-CN across 100 loci. A combination of fine-mapping, variant annotation, and co-localization analyses was used to prioritize genes within each of the 133 independent sites. Putative causal genes were enriched for known mitochondrial DNA depletion syndromes (p = 3.09 × 10–15) and the gene ontology (GO) terms for mtDNA metabolism (p = 1.43 × 10–8) and mtDNA replication (p = 1.2 × 10–7). A clustering approach leveraged pleiotropy between mtDNA-CN associated SNPs and 41 mtDNA-CN associated phenotypes to identify functional domains, revealing three distinct groups, including platelet activation, megakaryocyte proliferation, and mtDNA metabolism. Finally, using mitochondrial SNPs, we establish causal relationships between mitochondrial function and a variety of blood cell-related traits, kidney function, liver function and overall (p = 0.044) and non-cancer mortality (p = 6.56 × 10–4).
Energy minimizers for an asymptotic MEMS model with heterogeneous dielectric properties
Authors: Laurençot Philippe , Nik Katerina , Walker Christoph 
Published: December 2021

AbstractA model for a MEMS device, consisting of a fixed bottom plate and an elastic plate, is studied. It was derived in a previous work as a reinforced limit when the thickness of the insulating layer covering the bottom plate tends to zero. This asymptotic model inherits the dielectric properties of the insulating layer. It involves the electrostatic potential in the device and the deformation of the elastic plate defining the geometry of the device. The electrostatic potential is given by an elliptic equation with mixed boundary conditions in the possibly non-Lipschitz region between the two plates. The deformation of the elastic plate is supposed to be a critical point of an energy functional which, in turn, depends on the electrostatic potential due to the force exerted by the latter on the elastic plate. The energy functional is shown to have a minimizer giving the geometry of the device. Moreover, the corresponding Euler–Lagrange equation is computed and the maximal regularity of the electrostatic potential is established.
Diversity of carbapenem-resistant Klebsiella pneumoniae ST14 and emergence of a subgroup with KL64 capsular locus in the Arabian Peninsula
Authors: Mouftah Shaimaa F. , Pál Tibor , Higgins Paul G. , Ghazawi Akela , Idaghdour Youssef , Alqahtani Manaf , Omrani Ali S. , Rizvi Tahir A. , Sonnevend Ágnes 
Published: December 2021

AbstractTo understand the reasons of successful spread of carbapenem-resistant Klebsiella pneumoniae ST14 (CRKP-ST14) in countries of the Arabian Peninsula, the resistome, capsular locus, carbapenemase carrying plasmid types, and core genome of isolates from the region were compared to global isolates. Thirty-nine CRKP-ST14 strains isolated from 13 hospitals in the United Arab Emirates, Bahrain, and Saudi Arabia were selected for whole genome sequencing on Illumina MiSeq platform based on the variety of carbapenemase genes carried and plasmids bearing these genes. Their resistome, capsular locus, and core genome MLST were compared to 173 CRKP-ST14 genomes available in public databases. The selected 39 CRKP-ST14 produced either NDM-1, OXA-48, OXA-162, OXA-232, KPC-2, or co-produced NDM-1 and an OXA-48-like carbapenemase. cgMLST revealed three clusters: 16 isolates from five UAE cities (C1), 11 isolates from three UAE cities and Bahrain (C2), and 5 isolates from Saudi Arabia (C3), respectively, and seven singletons. Resistance gene profile, carbapenemase genes, and their plasmid types were variable in both C1 and C2 clusters. The majority of CRKP-ST14 had KL2, but members of the C2 cluster and two further singletons possessed KL64 capsular locus. Based on cgMLST comparison of regional and global isolates, CRKP-ST14 with KL64 from four continents formed a distinct cluster, suggesting a recent emergence and spread of this variant. Our findings confirmed clonal transmission coupled with likely horizontal gene transfer in carbapenem-resistant Klebsiella pneumoniae ST14. Dissemination of this genetically flexible, highly resistant clone warrants further monitoring.
Equivalent cyclic polygon of a euclidean travelling salesman problem tour and modified formulation
Authors: Herraiz A. , Gutierrez M. , Ortega-Mier M. 
Published: December 2021

AbstractWe define a geometric transformation of Euclidean Travelling Salesman Problem (TSP) tours that leads to a new formulation of the TSP. For every Euclidean TSP n-city tour, it is possible to construct an inscribed n-polygon (Equivalent Cyclic Polygon, ECP) such that the lengths of the edges are equal to the corresponding TSP tour links and follow the same sequence order. The analysis of the ECP elicits the possibility of defining a new objective function in terms of angles instead of distances. This modification opens the way to identify characterizing geometric parameters of the TSP as well as to explore new heuristics based on the inclusion of additional constraints. The experimentation with a set of cases shows promising results compared to the traditional compact formulations. The behavior of the ECP-based TSP formulations is better when the nodes of the TSP are randomly or evenly distributed.
Inverted Hierarchies on the Shop Floor: The Organisational Layer of Workarounds for Collaboration in the Metal Industry
Authors: Mörike Frauke 
Published: December 2021

AbstractWorkarounds, or practices that deviate from the official pathway to a target, are frequent phenomena in the organisational context. With respect to collaboration, they highlight an area of mismatch between normative versus lived work practices, and therefore depict a relevant research area deeply rooted in computer supported cooperative work (CSCW). Building on the theory of hierarchical opposition by Louis Dumont and empirical data collected through ethnographic research at a company classified as a small- and medium-sized enterprise (SME) in the German metal industry, this paper addresses the emergence of workarounds in collaborative work processes by setting them into the wider organisational context. The organisational layer of analysis reveals that workarounds emerge to cater for inversed information power relations and information asymmetries in the shop floor setting, which require communication to flow against the hierarchical slope between planning and execution functions. By applying an organisational lens to the concept of workarounds, this paper contributes a novel empirical analysis that confirms the value of workarounds as a source of insight into collaborative practices.
A large neighborhood search approach for the paint shop scheduling problem
Authors: Winter Felix , Musliu Nysret 
Published: December 2021

AbstractMinimizing the setup costs caused by color changes is one of the main concerns for paint shop scheduling in the automotive industry. Yet, finding an optimized color sequence is a very challenging task, as a large number of exterior systems for car manufacturing need to be painted in a variety of different colors. Therefore, there is a strong need for efficient automated scheduling solutions in this area. Previously, exact and metaheuristic approaches for creating efficient paint shop schedules in the automotive supply industry have been proposed and evaluated on a publicly available set of real-life benchmark instances. However, optimal solutions are still unknown for many of the benchmark instances, and there is still a potential of reducing color change costs for large instances. In this paper, we propose a novel large neighborhood search approach for the paint shop scheduling problem. We introduce innovative exact and heuristic solution methods that are utilized within the large neighborhood search and show that our approach leads to improved results for large real-life problem instances compared to existing techniques. Furthermore, we provide previously unknown upper bounds for 14 benchmark instances using the proposed method.
IPSC-Derived Human Neurons with GCaMP6s Expression Allow In Vitro Study of Neurophysiological Responses to Neurochemicals
Authors: Galiakberova A. A. , Surin A. M. , Bakaeva Z. V. , Sharipov R. R. , Zhang Dongxing , Dorovskoy D. A. , Shakirova K. M. , Fisenko A. P. , Dashinimaev E. B. 
Published: December 2021

AbstractThe study of human neurons and their interaction with neurochemicals is difficult due to the inability to collect primary biomaterial. However, recent advances in the cultivation of human stem cells, methods for their neuronal differentiation and chimeric fluorescent calcium indicators have allowed the creation of model systems in vitro. In this paper we report on the development of a method to obtain human neurons with the GCaMP6s calcium indicator, based on a human iPSC line with the TetON–NGN2 transgene complex. The protocol we developed allows us quickly, conveniently and efficiently obtain significant amounts of human neurons suitable for the study of various neurochemicals and their effects on specific neurophysiological activity, which can be easily registered using fluorescence microscopy. In the neurons we obtained, glutamate (Glu) induces rises in [Ca2+]i which are caused by ionotropic receptors for Glu, predominantly of the NMDA-type. Taken together, these facts allow us to consider the model we have created to be a useful and successful development of this technology.
Executive equity incentives and opportunistic manager behavior: new evidence from a quasi-natural experiment
Authors: Nienhaus Martin 
Published: December 2021

AbstractThis study provides plausible causal evidence on the effect of executive equity incentives on opportunistic manager behavior. I exploit a unique setting created by the introduction of Financial Accounting Standard (FAS) 123R in 2005, which led to an exogenous increase in the cost of option pay, causing a substantial decline in option pay for some firms while leaving others largely unaffected. Using difference-in-differences analyses with a treatment group of firms that show a decline in option pay and two control groups, I find that the likelihood of a treatment firm meeting or beating analyst forecasts decreases by 14–20%. The results show that the relatively high levels of meet-or-beat before FAS 123R were largely driven by real activities manipulation such as abnormal asset sales and sales manipulation to beat analysts’ benchmarks, while accrual manipulation and analyst management were less relevant. Together, the results suggest that equity incentives encourage opportunistic actions to meet or beat earnings expectations, and a decline in option pay results in a decline in earnings management to meet earnings expectations.
The 2021 chemistry Nobel laureates and asymmetric organocatalysis
Authors: Hargittai Istvan 
Published: December 2021

AbstractThe 2021 Nobel Prize in Chemistry was awarded jointly to Benjamin List and David MacMillan “for the development of asymmetric organocatalysis.” This choice was remarkable for a number of reasons. It singled out a very “chemical” discovery, whereas in recent years, the chemistry prizes often went for discoveries in biochemistry, and it singled out two relatively young men. The concept of asymmetric organocatalysis has been around since the late 1920s, and in the early 1970s, even proline was recognized as capable of playing the role of an enzyme. Nonetheless, asymmetric organocatalysis has found major applications since about the year 2000 due to the discoveries and activities of the new laureates and their colleagues.
Hamiltonian energy and coexistence of hidden firing patterns from bidirectional coupling between two different neurons
Authors: Njitacke Zeric Tabekoueng , Koumetio Bernard Nzoko , Ramakrishnan Balamurali , Leutcho Gervais Dolvis , Fozin Theophile Fonzin , Tsafack Nestor , Rajagopal Kartikeyan , Kengne Jacques 
Published: December 2021

AbstractIn this paper, bidirectional-coupled neurons through an asymmetric electrical synapse are investigated. These coupled neurons involve 2D Hindmarsh–Rose (HR) and 2D FitzHugh–Nagumo (FN) neurons. The equilibria of the coupled neurons model are investigated, and their stabilities have revealed that, for some values of the electrical synaptic weight, the model under consideration can display either self-excited or hidden firing patterns. In addition, the hidden coexistence of chaotic bursting with periodic spiking, chaotic spiking with period spiking, chaotic bursting with a resting pattern, and the coexistence of chaotic spiking with a resting pattern are also found for some sets of electrical synaptic coupling. For all the investigated phenomena, the Hamiltonian energy of the model is computed. It enables the estimation of the amount of energy released during the transition between the various electrical activities. Pspice simulations are carried out based on the analog circuit of the coupled neurons to support our numerical results. Finally, an STM32F407ZE microcontroller development board is exploited for the digital implementation of the proposed coupled neurons model.
Influence of dressing strategy on tool wear and performance behavior in grinding of forming tools with toric grinding pins
Authors: Denkena Berend , Krödel-Worbes Alexander , Keitel Michael , Wolters Philipp 
Published: December 2021

AbstractThe performance of grinding tools in grinding processes and the resulting surface and subsurface properties depend on various factors. The condition of the grinding tool after dressing is one of these factors. However, the influence of the dressing process on the condition of the grinding tool depends on the selected process parameters and is difficult to predict. Therefore, this paper presents an approach to describe the influence of the dressing process on tool wear of toric grinding pins and the resulting subsurface modification. For this purpose, toric grinding pins with a vitrified bond were dressed with two different strategies and the wear and operational behavior were investigated when grinding AISI M3:2 tool steel with two different grinding strategies. In general, the investigations have shown that the dressing process influences the performance and wear behavior differently depending on the grinding strategy used. The degree of clogging is influenced by the geometric contact sizes. In the case of small engagement cross sections with simultaneously large contact lengths the thermal tool load is distributed over a small annular area of the tool and favors clogging. Crushing and additional transverse loading of the grains result in an almost clog-free tool surface. This also leads to a lower G-ratio. Crushing leads to an intensified decrease of the torus radii. The influence of the dressing strategy can also be observed in the induced residual stresses. Toric grinding pins dressed by crushing induce lower compressive residual stresses into the workpiece, which can be attributed to the self-sharpening effect. This effect reduces the mechanical and thermomechanical load of the workpiece during machining.
When the winner takes it all: online campaign factors influencing the success of donation-based crowdfunding for charitable causes
Authors: Salido-Andres Noelia , Rey-Garcia Marta , Alvarez-Gonzalez Luis Ignacio , Vazquez-Casielles Rodolfo 
Published: December 2021

AbstractThis research explores the extent to which campaign factors may influence the success of donation-based crowdfunding (DCF) promoted online with social purposes. Factors that may explain the success of online fundraising campaigns for social causes are firstly identified from previous literature and linked to DCF campaigns through a set of hypotheses: disclosure, imagery, updating, and spreadability. Following, their explanatory capacity is measured through quantitative analysis (logistic regression) based on 360 all-or-nothing campaigns fostered by nonprofits through an online platform. Results confirm the high explanatory capacity of determinants related to the updating and spreadability of the campaign. However, factors related to the disclosure and imagery do not influence their success. This research suggests that the success of online campaigns is closely related to share and update transparent information of those details that contributors deem relevant. Implications are drawn for the effective technical design and management of DCF campaigns channeled through digital media, and specifically for the engagement with potential online communities of funders in digital platforms.
School-Based Mental Health Promotion and Early Intervention Programs in New South Wales, Australia: Mapping Practice to Policy and Evidence
Authors: Laurens Kristin R. , Graham Linda J. , Dix Katherine L. , Harris Felicity , Tzoumakis Stacy , Williams Kate E. , Schofield Jill M. , Prendergast Traci , Waddy Neale , Taiwo Mary , Carr Vaughan J. , Green Melissa J. 
Published: December 2021

AbstractLimited empirical evidence is available regarding the uptake and effectiveness of school-based mental health and wellbeing programs implemented in Australian schools. This study aimed to characterise the delivery of programs in primary (elementary) schools across New South Wales, Australia, and to assess this information against published ratings of program effectiveness. Delivery of programs in four health-promoting domains—creating a positive school community; teaching social and emotional skills; engaging the parent community; and supporting students experiencing mental health difficulties—were reported by 597 school principals/leaders via online survey. Although three quarters of principals reported implementing at least one program, many of these programs were supported by little or no evidence of effectiveness. There was also variability in the use of evidence-based programs across the four domains. Findings indicate a need to provide educators with improved support to identify, implement, and evaluate effective evidenced-based programs that promote student mental health.