bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcomatoid Carcinoma Arising in a Gastric Duplication Cyst
Authors: Ahmed Mohamed A. H. , Liyanaarachchi Kanchana Sanjeewani , Preston Shaun R. , Hewish Madeleine , Bagwan Izhar N. 
Published: May 2021

ABSTRACT
Malignancy arising within a gastric duplication cyst (GDC) is extremely rare; only 15 cases have been reported in the literature. We present a 70-year-old woman who was referred with a history of vague postprandial abdominal discomfort. Subsequent imaging identified a gastric cystic mass. A laparoscopic sleeve gastrectomy of a 90 × 60 × 60-mm cystic mass was performed. Histopathological examination showed the presence of a sarcomatoid carcinoma arising within a GDC. The patient, unfortunately, died 5 months after surgery with metastatic disease. To the best of our knowledge, this is the first case of sarcomatoid carcinoma arising within a GDC.
Recurrent Candida-Associated Esophageal Strictures in an Immunocompetent Patient
Authors: Narang Natasha , Pinillos Hugo , Amog-Jones Glenda , Gomez Adam , Alishahi Yasmin 
Published: May 2021

ABSTRACT
Esophageal stricture due to Candida esophagitis is a rare complication reported among immunocompromised patients in only limited case reports. We describe a unique case of a 36-year-old man with chronic mucocutaneous candidiasis without underlying immunocompromise who experienced over 10 years of recurrent dysphagia due to esophageal strictures from candidiasis. His symptoms were initially believed to be due to eosinophilic esophagitis; however, numerous biopsies from the esophagus were negative for eosinophils. Several upper endoscopies, however, did reveal fungal elements consistent with Candida spp. He experienced recurring episodes of dysphagia and persistent esophageal stricture, requiring multiple antifungal courses and endoscopic balloon dilatations.
Inflammatory Bowel Disease and Primary Sclerosing Cholangitis in a Pediatric Patient With Neurofibromatosis Type 1
Authors: Lehan Emily , Wang Tao , Soboleski Don , Acker Amy , Kehar Mohit 
Published: May 2021

ABSTRACT
We describe a case of a 15-year-old adolescent boy with neurofibromatosis type 1 who presented with inflammatory bowel disease and primary sclerosing cholangitis. The literature available on the association of neurofibromatosis type 1 with inflammatory bowel disease is limited to 7 clinical case reports, and none had comorbid primary sclerosing cholangitis. We present a review of the published literature on this rare association and add the findings of our patient.
Pediatric reference interval verification for common biochemical assays on the Abbott Alinity system
Authors: Bohn Mary Kathryn , Wilson Siobhan , Hall Alexandra , Massamiri Youssef , Randell Ed , Adeli Khosrow 
Published: May 2021

Abstract

Objectives
The quality of clinical laboratory service depends on quality laboratory operations and accurate test result interpretation based on reference intervals (RIs). As new analytical systems continue to be developed and improved, previously established RIs must be verified. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has established comprehensive RIs for many biomarkers on several analytical systems. Here, published CALIPER RIs for 28 chemistry assays on the Abbott ARCHITECT were assessed for verification on the newer Alinity system.

Methods
An analytical validation was first completed to assess assay performance. CALIPER serum samples (100) were analyzed for 28 chemistry assays on the Alinity system. The percentage of results falling within published pediatric ARCHITECT reference and confidence limits was determined for each analyte. Based on Clinical and Laboratory Standards Institute (CLSI) guidelines, if ≥90% of test results fell within confidence limits of ARCHITECT assay RIs, they were considered verified.

Results
Of the 28 assays assessed, 26 met the criteria for verification. Reference values for calcium and magnesium did not meet the criteria for verification with 87% and 35% falling within previously established ARCHITECT confidence limits, respectively. However, both assays could be verified using pediatric RIs provided in the Abbott Alinity package insert.

Conclusions
In this study, CALIPER ARCHITECT RIs were verified on the Alinity system for several chemistry assays. These data demonstrate excellent concordance for most assays between the Abbott ARCHITECT and Alinity systems and will assist in the implementation of the Alinity system in pediatric healthcare institutions.
Hepatic stellate cells: current state and open questions
Authors: Kordes Claus , Bock Hans H. , Reichert Doreen , May Petra , Häussinger Dieter 
Published: May 2021

Abstract
This review article summarizes 20 years of our research on hepatic stellate cells within the framework of two collaborative research centers CRC575 and CRC974 at the Heinrich Heine University. Over this period, stellate cells were identified for the first time as mesenchymal stem cells of the liver, and important functions of these cells in the context of liver regeneration were discovered. Furthermore, it was determined that the space of Disse – bounded by the sinusoidal endothelium and hepatocytes – functions as a stem cell niche for stellate cells. Essential elements of this niche that control the maintenance of hepatic stellate cells have been identified alongside their impairment with age. This article aims to highlight previous studies on stellate cells and critically examine and identify open questions and future research directions.
Evaluation of reproductive hormones in Egyptian workers occupationally exposed to di-2-ethylhexyl phthalate (DEHP): a cross-sectional study
Authors: Metwally Fateheya M. , Elfiky Asmaa M. , Sharaf Neven E. , Rashad Hend 
Published: May 2021

Abstract

Objectives
Di-2-ethylhexyl phthalate (DEHP) is ubiquitous, known as an endocrine disruptor. DEHP is a widespread prevalence in general and occupational populations which raised great public concerns due to its potentially harmful health effects on the male reproductive system. We aimed to assess occupational levels of DEHP on gonadotropin and gonadal hormones including luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (TT), and sex hormone binding globulin (SHBG) and evaluate its potential effects on Asp327Asn polymorphisms SHBG gene.

Methods
We measured the levels of DEHP of 90 male workers in one of polyvinyl chloride (PVC) industry plant using enzyme-linked immunosorbent assay. Sex hormones were examined and Asp327Asn polymorphisms SHBG gene were detected by PCR-RFLP in all participants.

Results
The workers were divided into low- and high- DEHP exposed groups based on the geometric mean (GM) levels (183.86 U/L) in serum. TT and TT: LH ratio were negatively correlated to DEHP levels (r=−0.213, p=0.038), (r=−0.225, p=0.027), respectively. The linear regression analysis revealed that a 10-fold increase of serum DEHP was found to be associated with 2.07 fold decreased in TT and a 2.26 fold decreased in TT/LH ratio.

Conclusions
Serum testosterone is negatively associated with DEHP exposure in occupational workers.
A critical review of optical switches
Authors: Singh Ompal , Paulus Rajeev 
Published: May 2021

AbstractOptical packet switching has gained lot of popularity in last a few years due to its advantages like, large speed, more bandwidth and very less crosstalk. But due to immature optical fabrication and designing technology OPS is still beyond reality. However, many of the optical components are commercialized and some of them are still in laboratory. Thus, for optical switches which are considered as future generation routers, many switch architectures are proposed by using different sets of optical components. This paper presents a detailed review of notable switch designs in past 20 years, and also presents a comprehensive literature survey of the notable papers related to optical packet switch designs.
The Multiple Regulator Model: A Case of Too Many Cooks?
Authors: Perai Nur Azam Anuarul 
Published: May 2021

Abstract
Regulation protects the third sector from mismanagement, provides data for policy development, and increases public trust and confidence in its organisations. Different agencies regulate Malaysian third sector organisations (TSO), based on their legal forms and varying activities or functions. Yet, can different regulations governing organisations with similar objectives effectively address issues affecting the sector as a whole? This study provides an overview of the Malaysian third sector regulatory landscape and examines the operational challenges caused by the multiple regulator environment. Third sector actors and regulators were interviewed to understand how they navigate legal and regulatory requirements. Findings show that regulation is hampered by discrepancies surrounding the interpretation and application of laws. This Malaysian study shows that regulatory inconsistencies affect the sector’s operational efficiency and diminish trust between the TSOs and regulators. Based on these findings, uniformity in regulation is crucial to build trust in the sector, as well as between actors and regulators.
Der Handschlag von Therwil – Einsichten in die Aushandlungsdynamiken von Religion zwischen lokaler Interaktion, nationaler Politisierung und globaler Skandalisierung: Eine Einleitung
Authors: Hetmanczyk Philipp , Walthert Rafael 
Published: May 2021

Zusammenfassung
Im November 2015 ereignete sich an einer Schweizer Sekundarschule ein Vorfall, der in der Folge als sogenannter „Handschlag von Therwil“ Schlagzeilen machte. Mit diesem Topos ist jedoch nicht nur die Entscheidung zweier Schüler gemeint, ihrer Lehrerin unter Verweis auf religiöse Motive den Handschlag zu verweigern, sondern ebenso die medialen, schulischen, politischen und rechtlichen Konsequenzen, die sich an diese Episode anschlossen. Die folgende Einleitung zu dieser Thematik bietet, neben einer Schilderung des Vorfalls, eine Rahmensetzung, die sich mit dem religionswissenschaftlichen Stellenwert lokaler Aushandlungsprozesse von Religion befasst. Es wird argumentiert, dass lokale Aushandlungen von Religion weder rein binnenreligiös noch in den sozialen und räumlichen Grenzen ihrer Lokalität vollzogen werden. Stattdessen sind sie in eine Vielzahl nicht-religiöser und translokaler Kontexte eingebunden. Daraus ergibt sich eine Reihe von Fragestellungen: Unter welchen Umständen werden lokale Religionsthematiken zum Verhandlungsgegenstand anderer, nicht-religiöser Gesellschaftsbereiche? Wie wirken diese Dynamiken auf lokale Aushandlungsprozesse zurück und welche Themen fungieren dabei als Kristallisationspunkte? Nicht zuletzt stellt sich zudem die Frage nach geeigneten Konzepten und Ansätzen, anhand derer die Aushandlungsprozesse von Religion in nicht religiösen Kontexten adäquat erfasst werden können. Die vorliegende Einleitung stellt verschiedene Beiträge vor, die sich in ihrer Analyse des Therwiler Handschlags auf unterschiedliche Weise diesen Fragen angenähert haben.
Extended visible light driven photocatalytic hydrogen generation by electron induction from g-C3N4 nanosheets to ZnO through the proper heterojunction
Authors: Zada Amir , Khan Muhammad , Hussain Zahid , Shah Muhammad Ishaq Ali , Ateeq Muhammad , Ullah Mohib , Ali Nauman , Shaheen Shabana , Yasmeen Humaira , Ali Shah Syed Niaz , Dang Alei 
Published: May 2021

Abstract
The alarming energy crises has forced the scientific community to work for sustainable energy modules to meet energy requirements. As for this, ZnO/g-C3N4 nanocomposites with proper heterojunction were fabricated by coupling a proper amount of ZnO with 2D graphitic carbon nitride (g-C3N4) nanosheets and the obtained nanocomposites were applied for photocatalytic hydrogen generation from water under visible light illumination (λ > 420 nm). The morphologies and the hydrogen generation performance of fabricated photocatalysts were characterized in detail. Results showed that the optimized 5ZnO/g-C3N4 nanocomposite produced 70 µmol hydrogen gas in 1 h compare to 8 µmol by pure g-C3N4 under identical illumination conditions in the presence of methanol without the addition of cocatalyst. The much improved photoactivities of the nanocomposites were attributed to the enhanced charge separation through the heterojunction as confirmed from photoluminescence study, capacity of the fabricated samples for •OH radical generation and steady state surface photovoltage spectroscopic (SS-SPS) measurements. We believe that this work would help to fabricate low cost and effective visible light driven photocatalyst for energy production.
Lagerverhalten unter Prognoseunsicherheit mit dynamischen Bestellpolitiken
Authors: Fritzsch Benjamin , Müller Domenic , Nitsche Andreas , Nyhuis Peter 
Published: May 2021

Abstract
Bei der Produktion von Lagergütern stehen produzierende Unternehmen einem unsicheren Kundenbedarf gegenüber. Um Unsicherheiten zu begegnen, ist ein erhöhter Lagerbestand notwendig, um die Kundenbedarfe anforderungsgerecht bedienen zu können. Die entstehenden Kosten sind bei gegebener Prognoseunsicherheit durch das Bestellverhalten beeinflusst. Das Bestellverhalten wird maßgeblich von der Bestellpolitik bestimmt. Daher wurde der Einfluss von Prognoseunsicherheit und der Bestellpolitik auf die entstehenden Lagerkosten mittels Sensitivitätsanalysen untersucht. Prognoseunsicherheiten bedürfen bei der (t, S)-Politik demnach größerer Bestände als unter der (s, q)-Politik.
Anwendungen des maschinellen Lernens in der Produktion aus Auftrags- und Produktsicht
Authors: Denkena Berend , Dittrich Marc-André , Noske Hendrik , Kramer Kathrin , Schmidt Matthias 
Published: May 2021

Abstract
Das maschinelle Lernen als Teilgebiet der Künstlichen Intelligenz kann in der Fertigung dazu beitragen, Prozesse beschleunigt auszulegen, Zykluszeiten und Ausschuss zu reduzieren und Produktionskapazitäten besser auszuschöpfen. Dieser Beitrag gibt einen systematisierten Überblick über Anwendungen des maschinellen Lernens für produkt- und auftragsbezogene Prozesse und unterstützt Praxisanwender dabei, Einsatzfelder gezielt zu identifizieren und Wertschöpfungspotenziale zu erschließen.
Magnetführung in der Optikfertigung
Authors: Denkena Berend , Bergmann Benjamin , Schmidtmann Jan-Philipp 
Published: May 2021

Abstract
Im Exzellenzcluster „PhoenixD“ forschen Wissenschaftler der Leibniz Universität Hannover an Methoden zur produktiven Herstellung von präzisionsoptischen Bauteilen. In einem Teilprojekt wird am Institut für Fertigungstechnik und Werkzeugmaschinen (IFW) ein Linearaktor mit elektromagnetischer Führung entwickelt. Mit dem Aktor können die Bauteile in den Herstellungsprozessen präzise ausgerichtet werden, Prozesskräfte angepasst und alle wichtigen Prozessgrößen in Echtzeit gemessen werden.
Software für eine automatisierte mehrdimensionale Fabriklayoutoptimierung
Authors: Aurich Paul , Stonis Malte , Nyhuis Peter 
Published: May 2021

Abstract
Die Layoutplanung ist eine komplexe Planungsaufgabe im Rahmen einer Fabrikplanung, welche bisher meist manuell ausgeführt werden musste. Zwar wurden in der Vergangenheit viele Optimierungsverfahren für die zugrundeliegende Problemstellung entwickelt, jedoch waren diese nur für einen kleinen meist universitären Expertenkreis anwendbar. Daher wurde in einem Forschungsprojekt eine einfach anwendbare Software zur Layoutplanung entwickelt, um Unternehmen einen Zugang zu diesen Optimierungsverfahren zu bereiten.
Considerations for the Physical Preparation of Freestyle Snowboarding Athletes
Authors: Dann Rick A. , Kelly Vincent G. 
Published: May 2021

ABSTRACT
The rapid growth in trick progression for competitive snowboarding over the past 20 years has resulted in increased physical demands required from snowboarding athletes. Despite a wealth of knowledge surrounding strength and conditioning principles for other sports, researchers are yet to address the novel strength and conditioning challenges faced by the freestyle nature of competitive snowboarding. This article, therefore, offers practitioners strategies to address the unique considerations surrounding cultural qualities, injury prevention, unstable surface training, skill acquisition, and recovery strategies for the effective implementation of strength and conditioning interventions for snowboarding athletes.
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer
Authors: Jin Meihua , Lee Woo Kyung , You Mi-Hyeon , Jang Ahreum , Cheng Sheue-yann , Kim Won Gu , Jeon Min Ji , Lee Yu-Mi 
Published: May 2021

Background
Catabolism of serine via serine hydroxymethyltransferase2 (SHMT2) through the mitochondrial one-carbon unit pathway is important in tumorigenesis. Therefore, SHMT2 may play a role in thyroid cancer.

Methods
Thyroid tissue samples and The Cancer Genome Atlas (TCGA) database were used to evaluate SHMT2 expression in thyroid tissues and the association with clinical outcomes.

Results
SHMT2 protein expression was evaluated in thyroid tissues consisting of 52 benign nodules, 129 papillary thyroid carcinomas (PTC) and matched normal samples, and 20 anaplastic thyroid carcinomas (ATC). ATCs presented the highest (95.0%) positivity of SMHT2 protein expression. PTCs showed the second highest (73.6%) positivity of SHMT2 expression, which was significantly higher than that of benign nodules (19.2%, P = 0.016) and normal thyroid tissues (0%, P < 0.001). Analysis of TCGA data showed that SHMT2 messenger RNA (mRNA) expression was significantly higher in tumors than in normal tissues (P < 0.001). When we classified thyroid cancer into high and low groups according to SHMT2 mRNA expression levels, the thyroid differentiation score for the high SHMT2 group was significantly lower than that of the low SHMT2 group (P < 0.001). There was also a significant correlation between SHMT2 mRNA expression and the stemness index (r = 0.41, P < 0.001). The high SHMT2 group had more advanced TNM stages and shorter progression-free survival rates than the low SHMT2 group (P < 0.01 and P = 0.007, respectively).

Conclusion
SHMT2 expression is higher in thyroid cancers than normal or benign tissues and is associated with de-differentiation and poor clinical outcomes. Thus, SHMT2 might be useful as a diagnostic and prognostic marker for thyroid cancer.
Computational design of 3D-printed active lattice structures for reversible shape morphing
Authors: Lumpe Thomas S. , Shea Kristina 
Published: May 2021

Abstract
Active structures can adapt to varying environmental conditions and functional requirements by changing their shapes and properties, which makes them suitable for applications in changing environments as found in aerospace and automotive. Of special interest are light and stiff structures with shape morphing capabilities, which is naturally contradictory. Existing concepts in literature can be limited to a single, non-reversible actuation and are difficult to design due to the inherent complexity of large-scale lattices with many elements and complex target deformations. Here, we show how 3D-printed active materials can be combined with an efficient computational framework to design large-scale lattice structures that can change their shape between an initial state and a target state. The reversible deformation is controlled by a single actuation input and heating of the structure. Numerical and experimental results show the generality of the proposed method and the applicability to different problems such as morphing airfoils.

Graphic Abstract
The Roman aqueduct of Brigetio
Authors: Benes Anita 
Published: May 2021

The aim of the present study is to examine the literary sources and the archaeological material regarding the aqueduct of Brigetio. Based on the available information the paper examines the problem of the localization of the source which supplied the aqueduct. The catalogue includes the descriptions of the lead and terracotta water pipes from Brigetio now in the Roman collection of the Hungarian National Museum. The results are presented with regards to the construction of the urban water distribution system.
A republican plated denarius from Aquincum
Authors: Juhász Lajos 
Published: May 2021

A puzzling plated republican denarius was found decades ago in the civil town of Aquincum. Due to its worn state its identification was troublesome, but it turned out to be an imitation of M. Furius’ coin minted in 119 BC. It is unique for Aquincum, and also quite rare in Pannonia, which raises a number of questions. Even more perplexing are the two mountings on the obverse, which served to fasten the coin to some other object. It is unfortunately impossible to tell, when and why this 2nd century BC plated denarius appeared in the 2–3rd centuries AD civil town.
Short report on the rescue excavations in the Roman Age Barbaricum near Abony (Pest County, Hungary)
Authors: Simon Bence , Joháczi Szilvia 
Published: May 2021

The staff of the Institute of Archaeological Sciences of Eötvös Loránd University unearthed a Sarmatian settlement and a cemetery near Abony (Pest County, Hungary) in the autumn of 2018. The preliminary results point to the area’s economic importance around the turn of the 2nd–3rd century AD.
Justification for use of selenium-modified mineral water in medical rehabilitation of patients who underwent colon surgery due to malignant tumor (overview)
Authors: Uzdenov Marat B. 
Published: May 2021

The article presents the justification for the use of selenium-modified low-mineralized mineral water of Chapaevsk deposit (the Karachay-Cherkess Republic), modified by selenium. It describes its effect on the state of hormonal and immune status, antioxidant system in malignant diseases of digestive organs, prevention of complications, reduction of dose of used medicines, improvement of quality of life of this category of patients.
Conclusion. It is noted that the use of selenium-modified low-mineralized mineral water expands and complements the possibilities of rehabilitation and rehabilitation assistance to patients who have undergone operations on the large intestine in case of malignant neoplasms.
A Nonparametric Hawkes Model for Forecasting California Seismicity
Authors: Gordon Joshua Seth , Fox Eric Warren , Schoenberg Frederic Paik 
Published: May 2021

ABSTRACT
A variety of nonparametric models have been proposed for estimating earthquake triggering. We investigate the ability of the model-independent stochastic declustering method developed by Marsan and Lengliné (2008) to estimate variable spatial triggering that can vary with direction, magnitude, and region. We develop an approach for local fault estimation and demonstrate forecasting methods that use the nonparametric estimates. Simulation studies are conducted to verify the effectiveness of the method, and the nonparametric estimates are applied to a California earthquake catalog. Model forecast performance is evaluated retrospectively by comparing our models with the long-term forecast of Helmstetter et al. (2007), using both deviance and Voronoi residuals. We show improved performance compared with Helmstetter et al. (2007) in various regions while using a full nonparametric estimation and forecasting approach.
i1-net: The Iran Strong Motion Network
Authors: Shahvar Mohammad Pourmohammad , Farzanegan Esmaeil , Eshaghi Attiyeh , Mirzaei Hossein 
Published: May 2021

AbstractStrong ground-motion records are the primary input data in earthquake engineering studies to improve understanding of seismic hazard and risk. As the overseer of the Iran Strong Motion Network (i1-net), the Road, Housing, and Urban Development Research Center occupies the leading position in this field in the country. With more than 1260 active accelerometers and a collection of over 14,129 earthquake recordings since 1973, the Iran Strong Motion Network is the major Iranian source of information for engineering seismology and earthquake engineering. The present article describes the current status and developments of the i1-net in the last 46 yr.