bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canada—Alberta
Authors: van Overdijk Claire , Martini Barb 
Published: March 2021

Abstract
Canada is a federation composed of ten provinces, including Alberta, and three territories. The common law applies in Canada, with the exception of the province of Quebec, which uses a civil law system. While there is a Federal Government, Alberta, as a province, also exercises constitutional powers in its own right. Federal legislation includes provisions relating to adults within the scope of this work. The Canadian Charter of Rights and Freedoms also guarantees certain political rights to Canadians and civil rights to everyone in Canada, and contains rights that impact upon capacity law.
Sweden
Authors: Frimston Richard , Odlöw Torbjörn 
Published: March 2021

Abstract
Sweden is a unitary state. Its legal system has the features that are distinctive to those of the Nordic legal family, as opposed to either civil law or common law systems. There are two parallel court systems in Sweden, general courts and administrative courts. There are also specialized courts, such as the Market Court, the Migration Courts, and the Labour Court.
Directors’ Duties
Authors: Joffe QC Victor , Drake David , Richardson Giles , Lightman QC Daniel , Collingwood Timothy 
Published: March 2021

Abstract
The general duties imposed upon directors are the corollary of their powers; they spring from the directors’ functional and normative role in conducting the company’s affairs and affecting its legal relations. Corporate law and the constitution of the company repose in them powers to act, within certain bounds, in the company’s name. And in doing so, they necessarily affect all those interested in the company’s fortunes: most fundamentally, its members. The separate legal personality afforded to a company serves, for the purposes of legal analysis, as a nexus for its members’ interests, and makes it possible to describe directors in the exercise of their powers as agents for the company. These tenets explain the origin of some of the basic duties that apply to directors in relation to the exercise of their functions: to promote the interests of the company; to exercise reasonable care, skill, and diligence; not to exceed the limits of their powers; not to profit from their position; and not to place themselves in positions where their own interests or other duties conflict with their duties to the company. In doing so, they draw on equitable and common law principles of wider application, to agents, trustees, partners, and professionals.
Enforcement of Planning Control
Authors: Bowes Ashley 
Published: March 2021

Abstract
The Agricultural Land (Removal of Surface Soil) Act 1953 provides that where the removal of surface soil from agricultural land constitutes development, it is an offence to do so without planning permission. Subject to that sole exception, to carry out the development of land without planning permission does not constitute a criminal offence. Nevertheless, there has to be some sanction to ensure that unauthorized development can be prevented. The sanction provided by the law is mainly imposed by the enforcement notice machinery contained in Part VII of the Town and Country Planning Act 1990. Under this machinery, once an enforcement notice takes effect, the development which is unauthorized must cease or be removed. If it is not, then, and only then, is a criminal offence committed of failure to comply with the enforcement notice.
Pediatric Reference Intervals for Critical Point-of-Care Whole Blood Assays in the CALIPER Cohort of Healthy Children and Adolescents
Authors: Bohn Mary Kathryn , Hall Alexandra , Wilson Siobhan , Henderson Tina , Adeli Khosrow 
Published: March 2021

Abstract

Objectives
Point-of-care testing (POCT) is being increasingly adopted to support clinical care. Data for critical care parameters in healthy children on POCT instruments are lacking. We established comprehensive reference standards for several whole blood parameters on the Radiometer ABL90 FLEX PLUS blood gas analyzer in the Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) cohort.

Methods
Approximately 300 healthy children and adolescents (age range, birth to &lt;19 years; sex, boys and girls) were recruited with informed consent. Venous whole blood was collected (using heparinized syringes) and rapidly analyzed at the point of collection for pH, Pco2, Po2, carboxyhemoglobin, methemoglobin, lactate, and electrolytes on the ABL90 FLEX PLUS instrument. Reference intervals were established according to Clinical and Laboratory Standards Institute guidelines.

Results
Of the parameters assessed, 6 required age partitioning; none required sex partitioning. Reference value distributions were consistent across the pediatric age range, demonstrating higher variation in the early neonatal period.

Conclusions
This study established reference standards for 10 critical care analytes in the CALIPER cohort for the first time. These data contribute to our understanding of normative pediatric values for venous electrolytes, metabolites, and blood gases on a modern POCT instrument, facilitating test interpretation in clinical settings that use these assays.
Invited Commentary: The Society for Epidemiologic Research Annual Meeting—Room to Improve Gender Equity
Authors: Lauderdale Diane S 
Published: March 2021

Abstract
The annual meeting of the Society for Epidemiologic Research is a prominent showcase for epidemiologists to present their research and share their expertise with peers. There are multiple paths to being on a podium at the meeting, and that role has implications for not only the speaker but also the audience. The article by Nobles et al. (Am J Epidemiol. 2021;190(9):1710–1720) represents an innovative investigation of representation among speakers at 3 recent SER annual meetings, with a primary focus on gender. Women were significantly under-represented as symposium speakers, which is an important role at the meeting. Symposium talks are invited talks and thus recognition of stature in the field. However, women were not under-represented as speakers in the concurrent contributed sessions, which are not invited talks and undergo blinded peer review. This gender contrast between the speakers at concurrent contributed sessions and the symposia is likely due to the different submission processes for the 2 types of presentations, but it could also reflect the review processes. Although the symposia are highly informative and enjoyable components of the meetings, some modifications in the submission and evaluation processes may be beneficial.
Improved yeast-screening assay for phytoestrogens
Authors: Sophon Natthida , Phiwpesh Choladda , Darith Sieng , Cherdshewasart Wichai , Boonchird Chuenchit 
Published: March 2021

ABSTRACT
A yeast estrogen screening (YES) assay was improved to increase sensitivity for detection of phytoestrogens. New yeast strains minus one or the other of transporters Pdr5 or Snq2 and harboring yEGFP as a reporter gene were developed. The new strains showed 2-100-fold improvement in sensitivity for detection of standard estrogens and antiestrogens. In addition, the assay time (1 h) using the newly developed strains was shorter than that (4 h) previously reported. Furthermore, the snq2-minus strains were most effective for detection of estrogenic activity while the pdr5-minus strains were most effective for detection of antiestrogenic activity. The efficacy of the new methods was evaluated and confirmed by testing with 23 Thai medicinal plant species. The new strains were also tested for detection of xenoestrogens. The results revealed that the newly developed YES methods were specific and rapid and suitable for simple high-throughput screening or detection of estrogen-like compounds.
nhKcr: a new bioinformatics tool for predicting crotonylation sites on human nonhistone proteins based on deep learning
Authors: Chen Yong-Zi , Wang Zhuo-Zhi , Wang Yanan , Ying Guoguang , Chen Zhen , Song Jiangning 
Published: March 2021

Abstract
Lysine crotonylation (Kcr) is a newly discovered type of protein post-translational modification and has been reported to be involved in various pathophysiological processes. High-resolution mass spectrometry is the primary approach for identification of Kcr sites. However, experimental approaches for identifying Kcr sites are often time-consuming and expensive when compared with computational approaches. To date, several predictors for Kcr site prediction have been developed, most of which are capable of predicting crotonylation sites on either histones alone or mixed histone and nonhistone proteins together. These methods exhibit high diversity in their algorithms, encoding schemes, feature selection techniques and performance assessment strategies. However, none of them were designed for predicting Kcr sites on nonhistone proteins. Therefore, it is desirable to develop an effective predictor for identifying Kcr sites from the large amount of nonhistone sequence data. For this purpose, we first provide a comprehensive review on six methods for predicting crotonylation sites. Second, we develop a novel deep learning-based computational framework termed as CNNrgb for Kcr site prediction on nonhistone proteins by integrating different types of features. We benchmark its performance against multiple commonly used machine learning classifiers (including random forest, logitboost, naïve Bayes and logistic regression) by performing both 10-fold cross-validation and independent test. The results show that the proposed CNNrgb framework achieves the best performance with high computational efficiency on large datasets. Moreover, to facilitate users’ efforts to investigate Kcr sites on human nonhistone proteins, we implement an online server called nhKcr and compare it with other existing tools to illustrate the utility and robustness of our method. The nhKcr web server and all the datasets utilized in this study are freely accessible at http://nhKcr.erc.monash.edu/.
Viewing Emerging Human Infectious Epidemics through the Lens of Invasion Biology
Authors: VilÀ Montserrat , Dunn Alison M , Essl Franz , GÓmez-DÍaz Elena , Hulme Philip E , Jeschke Jonathan M , NÚÑez MartÍn A , Ostfeld Richard S , Pauchard AnÍbal , Ricciardi Anthony , Gallardo Belinda 
Published: March 2021

Abstract
Invasion biology examines species originated elsewhere and moved with the help of humans, and those species’ impacts on biodiversity, ecosystem services, and human well-being. In a globalized world, the emergence and spread of many human infectious pathogens are quintessential biological invasion events. Some macroscopic invasive species themselves contribute to the emergence and transmission of human infectious agents. We review conceptual parallels and differences between human epidemics and biological invasions by animals and plants. Fundamental concepts in invasion biology regarding the interplay of propagule pressure, species traits, biotic interactions, eco-evolutionary experience, and ecosystem disturbances can help to explain transitions between stages of epidemic spread. As a result, many forecasting and management tools used to address epidemics could be applied to biological invasions and vice versa. Therefore, we advocate for increasing cross-fertilization between the two disciplines to improve prediction, prevention, treatment, and mitigation of invasive species and infectious disease outbreaks, including pandemics.
Rostro-caudal different energy metabolism leading to differences in degeneration in spinal cord injury
Authors: Ohnishi Yuichiro , Yamamoto Masamichi , Sugiura Yuki , Setoyama Daiki , Kishima Haruhiko 
Published: March 2021

Abstract
Spinal cord injury gradually spreads away from the epicentre of injury. The rate of degeneration on the rostral side of the injury differs from that on the caudal side. Rostral degeneration is an immediate process, while caudal degeneration is delayed. In this study, we demonstrated that the rostro-caudal differences in energy metabolism led to differences in the spread of degeneration in early thoracic cord injury using in vivo imaging. The blood flow at the rostral side of the injury showed ischaemia-reperfusion, while the caudal side presented stable perfusion. The rostral side had an ATP shortage 20 min after spinal cord injury, while the ATP levels were maintained on the caudal side. Breakdown products of purine nucleotides were accumulated at both sides of injury 18 h after spinal cord injury, but the principal metabolites in the tricarboxylic acid cycle and glycolytic pathway were elevated on the caudal side. Although the low-ATP regions expanded at the rostral side of injury until 24 h after spinal cord injury, the caudal-side ATP levels were preserved. The low-ATP regions on the rostral side showed mitochondrial reactive oxygen species production. Administration of 2-deoxy-d-glucose as a glycolysis inhibitor decreased the caudal ATP levels and expanded the low-ATP regions to the caudal side until 24 h after spinal cord injury. These results suggest that deficits in the glycolytic pathway accelerate the caudal degeneration, while immediate rostral degeneration is exacerbated by oxidative stress in early thoracic cord injury.
A Quantitative Assessment of the Net Wealth Tax: The Spanish Experience
Authors: Durán-Cabré José M , Esteller Moré Alejandro 
Published: March 2021

Abstract
There is growing debate, both social and academic, about the possibility of levying an annual net wealth tax. Until a few years ago, such a proposal appeared difficult to both implement and control, but recent technological innovations, which could greatly facilitate the periodic valuation of wealth, combined with improvements in international tax information sharing could make a “modern wealth tax” possible. Nonetheless, a number of challenges regarding its design still need to be addressed. Taking advantage of the Spanish experience—the only EU country to levy a wealth tax—we undertake a quantitative analysis of various key legal elements of the current tax (exemptions and the common income and wealth tax ceiling) by means of a tax simulator we have developed; we also analyze its redistributive power. Our results show that the family business exemption and the common ceilings are highly regressive. We also assess the effectiveness of alternative reforms with more comprehensive tax bases (JEL codes: H24, H23, and D31).
Day at the Races: Comparing BioFire FilmArray Blood Culture ID Panels With Verigene Blood Culture Panel in Gram-Negative Bloodstream Infections Using DOOR-MAT Analysis
Authors: Claeys Kimberly C , Schlaffer Kathryn , Smith Richard , Hitchcock Stephanie , Jiang Yunyun , Evans Scott , Johnson J Kristie , Leekha Surbhi 
Published: March 2021

Abstract
Three rapid diagnostic test panels (Verigene BC-GN, BioFire BCID, and BCID 2 [RUO]) were compared using the Desirability of Outcome Ranking Management of Antimicrobial Therapy (DOOR-MAT) to evaluate potential downstream antimicrobial prescribing decisions resulting from the panels’ different organism and resistance detection. BioFire BCID 2 (RUO) had the best mean DOOR-MAT scores.
Viral Sequencing to Investigate Sources of SARS-CoV-2 Infection in US Healthcare Personnel
Authors: Braun Katarina M , Moreno Gage K , Buys Ashley , Somsen Elizabeth D , Bobholz Max , Accola Molly A , Anderson Laura , Rehrauer William M , Baker David A , Safdar Nasia , Lepak Alexander J , O’Connor David H , Friedrich Thomas C 
Published: March 2021

Abstract

Background
Healthcare personnel (HCP) are at increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We posit that current infection control guidelines generally protect HCP from SARS-CoV-2 infection in a healthcare setting.

Methods
In this retrospective case series, we used viral genomics to investigate the likely source of SARS-CoV-2 infection in HCP at a major academic medical institution in the Upper Midwest of the United States between 25 March and 27 December 2020. We obtained limited epidemiological data through informal interviews and review of the electronic health record and combined this information with healthcare-associated viral sequences and viral sequences collected in the broader community to infer the most likely source of infection in HCP.

Results
We investigated SARS-CoV-2 infection clusters involving 95 HCP and 137 possible patient contact sequences. The majority of HCP infections could not be linked to a patient or coworker (55 of 95 [57.9%]) and were genetically similar to viruses circulating concurrently in the community. We found that 10.5% of HCP infections (10 of 95) could be traced to a coworker. Strikingly, only 4.2% (4 of 95) could be traced to a patient source.

Conclusions
Infections among HCP add further strain to the healthcare system and put patients, HCP, and communities at risk. We found no evidence for healthcare-associated transmission in the majority of HCP infections evaluated. Although we cannot rule out the possibility of cryptic healthcare-associated transmission, it appears that HCP most commonly become infected with SARS-CoV-2 via community exposure. This emphasizes the ongoing importance of mask wearing, physical distancing, robust testing programs, and rapid distribution of vaccines.
Plasma proteomics of green turtles (Chelonia mydas) reveals pathway shifts and potential biomarker candidates associated with health and disease
Authors: Marancik David P , Perrault Justin R , Komoroske Lisa M , Stoll Jamie A , Kelley Kristina N , Manire Charles A 
Published: March 2021

AbstractEvaluating sea turtle health can be challenging due to an incomplete understanding of pathophysiologic responses in these species. Proteome characterization of clinical plasma samples can provide insights into disease progression and prospective biomarker targets. A TMT-10-plex-LC–MS/MS platform was used to characterize the plasma proteome of five, juvenile, green turtles (Chelonia mydas) and compare qualitative and quantitative protein changes during moribund and recovered states. The 10 plasma samples yielded a total of 670 unique proteins. Using ≥1.2-fold change in protein abundance as a benchmark for physiologic upregulation or downregulation, 233 (34.8%) were differentially regulated in at least one turtle between moribund and recovered states. Forty-six proteins (6.9%) were differentially regulated in all five turtles with two proteins (0.3%) demonstrating a statistically significant change. A principle component analysis showed protein abundance loosely clustered between moribund samples or recovered samples and for turtles that presented with trauma (n = 3) or as intestinal floaters (n = 2). Gene Ontology terms demonstrated that moribund samples were represented by a higher number of proteins associated with blood coagulation, adaptive immune responses and acute phase response, while recovered turtle samples included a relatively higher number of proteins associated with metabolic processes and response to nutrients. Abundance levels of 48 proteins (7.2%) in moribund samples significantly correlated with total protein, albumin and/or globulin levels quantified by biochemical analysis. Differentially regulated proteins identified with immunologic and physiologic functions are discussed for their possible role in the green turtle pathophysiologic response and for their potential use as diagnostic biomarkers. These findings enhance our ability to interpret sea turtle health and further progress conservation, research and rehabilitation programs for these ecologically important species.
Vedolizumab and Anti-Tumour Necrosis Factor α Real-World Outcomes in Biologic-Naïve Inflammatory Bowel Disease Patients: Results from the EVOLVE Study
Authors: Bressler Brian , Yarur Andres , Silverberg Mark S , Bassel Marielle , Bellaguarda Emanuelle , Fourment Chris , Gatopoulou Anthie , Karatzas Pantelis , Kopylov Uri , Michalopoulos George , Michopoulos Spyridon , Navaneethan Udayakumar , Rubin David T , Siffledeen Jesse , Singh Andrew , Soufleris Konstantinos , Stein Dara , Demuth Dirk , Mantzaris Gerassimos J 
Published: March 2021

Abstract

Background and Aims
This study aimed to compare real-world clinical effectiveness and safety of vedolizumab, an α4β7-integrin inhibitor, and anti-tumour necrosis factor-α [anti-TNFα] agents in biologic-naïve ulcerative colitis [UC] and Crohn’s disease [CD] patients.

Methods
This was a 24-month retrospective medical chart study in adult UC and CD patients treated with vedolizumab or anti-TNFα in Canada, Greece and the USA. Inverse probability weighting was used to account for differences between groups. Primary outcomes were cumulative rates of clinical effectiveness [clinical response, clinical remission, mucosal healing] and incidence rates of serious adverse events [SAEs] and serious infections [SIs]. Secondary outcomes included cumulative rates of treatment persistence [patients who did not discontinue index treatment during follow-up] and dose escalation and incidence rates of disease exacerbations and disease-related surgeries. Adjusted analyses were performed using inverse probability weighting.

Results
A total of 1095 patients [604 UC, 491 CD] were included. By 24 months, rates of clinical effectiveness were similar between groups, but incidence rates of SAEs (hazard ratio [HR] = 0.42 [0.28–0.62]) and SIs (HR = 0.40 [0.19–0.85]) were significantly lower in vedolizumab vs anti-TNFα patients. Rates of treatment persistence [p &lt; 0.01] by 24 months were higher in vedolizumab patients with UC. Incidence rates of disease exacerbations were lower in vedolizumab patients with UC (HR = 0.58 [0.45–0.76]). Other outcomes did not significantly differ between groups.

Conclusion
In this real-world setting, first-line biologic therapy in biologic-naïve patients with UC and CD demonstrated that vedolizumab and anti-TNFα treatments were equally effective at controlling disease symptoms, but vedolizumab has a more favourable safety profile.