bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengujian Slag Nikel Sebagai Pengganti Agregat Pada Campuran HRS-Base
Authors: Arruantasik Demmalino Utami , Sielviana Widya Lambe Cyntia , Rahman Rais , Alpius  
Published: May 2021

Penelitian ini dimasukkan untuk menguji karakteristik campuran Lataston HRS-Base dengan memanfaatkan slag nikel berdasarkan pengujian laboratorium. Hasil penelitian menunjukkan bahwa karakteristik bahan perkerasan berupa slag nikel dari Soroako Kab. Luwu Timur memenuhi spasifikasi sebagai bahan lapisan permukaan jalan. Melalui uji Marshall diperoleh karakteristik campuran Lataston HRS-Base bergradasi senjang dan semi senjang dengan kadar aspal 5,0%, 5,93%, 6,35%, 6,78, dan 7,2% memenuhi persyaratan. Hasil pengujian Marshall Immertion campuran Lataston HRS-Base bergradasi senjang dan semi senjang pada kadar aspal optimum 6,35% mendapatkan Indeks Perendaman (IP) / Indeks Kekuatan Sisa (IKS) / Durabilitas campuran sebesar 97,03% dan 98,00% Dimana dari hasil penelitian ini dapat ditarik kesimpulan bahwa penggunaan slag nikel sebagai pengganti agregat kasar dapat dimanfaatkan sebagai bahan perkerasan jalan karena memenuhi Standar Spesifikasi Bina Marga.
Kata Kunci : Karakteristik Marshall, Lataston HRS-Base, Slag Nikel
Antibacterial Activity of Pakistani Honey
Authors: Shah Taif , Ali Niyaz , Shah Zahir , Hayat Azam 
Published: May 2021

The current study was conducted to determine the antibacterial activity of 50 crude and processed honey samples produced by Apis mellifera and stingless bee. All the honey samples were collected from different places of Districts Dir, Swat and Oghi of Khyber Pakhtunkhwa Province, Pakistan and were tested against the six ATCC bacterial species including E. coli ATCC number 25922, Pseudomonas aeruginosa ATCC number 27853, Staphylococcus aureus ATCC number 6538, Enterococcus faecalis ATCC number 19433, Salmonella typhi ATCC number 19943 and Klebsiella pneumoniae ATCC number 27736. The honey samples showed variable zones of inhibition by using Agar well plate technique. E. coli showed 17-23 mm, S. typhi 31-37 mm, E. faecalis 28 mm, P. aeruginosa 14-15 mm, K. pneumoniae 20-24 mm and Staph. aureus 19-25 mm. Most of the honey samples used in this study showed broad spectrum antibacterial activity.
ADAPTIVE POWER CONTROL ON DVB-T SYSTEM BASED ON NO-REFERENCE PERCEPTUAL PICTURE QUALITY METRIC
Authors: Rahmanto Randy , Ayuningtyas Belinda 
Published: May 2021

Digital Video Broadcasting – Terrestrial (DVB-T) adalah salah satu standar broadcast televisi digital di eropa. Ketika mentransmisikan data melalui sistem DVB-T, noise merupakan masalah yang tidak dapat dihindarkan. Masalah tersebut dapat menyebabkan penurunan kualitas video yang diterima oleh end user. Berdasarkan penjelasan diatas, penulis mendesain sebuah adaptive power control on DVB-T system based-on no-reference perceptual picture quality metric yang dapat menentukan berapa banyak transmit power yang dibutuhkan oleh receiver untuk mendapatkan hasil kualitas video yang baik. No-reference image metric akan digunakan untuk membuat visual quality feedback di sisi receiver. Hasil dari image metric ini berupa nilai dalam bentuk angka yang akan dikirimkan ke transmitter sebagai feedback. Di sisi transmitter, ada explicit link adaptation yang mengatur power menggunakan perceptual quality (PQ-based) berdasarkan visual quality feedback. Hasil dari adaptive power control menunjukkan bahwa, ketika visual quality feedback menunjukkan angka dibawah 96 poin ( unacceptable quality ), power akan dinaikkan sebesar 0.05 dB untuk meningkatkan kualitas video yang diterima. Sebaliknya, jika visual quality feedback menunjukkan lebih dari sama dengan 96 ( acceptable quality ), power akan diturunkan untuk menghemat biaya power cost. Adaptive power control memberikan hasil yang sangat baik karena secara signifikan dapat mengurangi nilai visual quality yang buruk pada simulasi dengan menggunakan power sebesar 18 dB.
Analysis of Municipal Solid Waste Generation in Dir City
Authors: Mahmood Shakeel 
Published: May 2021

The study is an attempt to analyze municipal solid waste generation Dir City, District Dir Upper Khyber Pakhtunkhwa (KP), Pakistan. This study has utilized primary data collected through a semi-structured questionnaire and direct waste sampling as primary research. Mathematical analysis and descriptive statistical analysis is applied and generation of municipal solid waste at different scales is estimated. Results indicated that the total waste generated was 16.65 million kg/annum (18356.5 tons) or 45624 kg/day (50.29 tons), or 0.37 kg/capita. Average waste produced by residential, commercial, educational and health sectors was 3.3 kg, 21 kg, 12 kg and 7 kg, correspondingly. Among all, residential sector was the leading producer with 40738 kg (89%) follow by commercial sector 4321 kg (9%) per day while remaining in fraction. High income households and large size families were producing average waste of 5.6 kg/day and 4.9 kg/day, respectively. The main components of waste generated in the study area included paper (8%), organic matter (53%), plastics (12%), clay, pebbles, gravels, ashes and broken ceramic objects (24.8%). The spatial distribution of waste generation varies across the city, high rate of generation was found Rehankot and Shaow whereas Fringe areas were characterized by low generation rate.
Neutrophil Gelatinase-Associated Lipocalin (NGAL): An Early Dual Biomarker in Diagnosis of Ascitic Fluid Infection and Acute Kidney Injury in Liver Cirrhosis in a Tertiary Centre, Egypt
Authors: Nassar Dalia Kamal , Elkenawy Mohammed Fouad , El-Naggar Mohammed Mahmoud , Khalil El-Sayed Abdul-Maksoud , Barakat Ghada Ibrahim 
Published: May 2021

Background: This study aimed to evaluate the ascitic Neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic biomarker for bacterial translocation or bactDNA translocation in ascites of cirrhotic patients and to evaluate the urinary NGAL for identifying renal dysfunction in patients with liver cirrhosis.
Methods: This study included 44 patients with ascites. Study participants were divided into two groups. Group (1) had 22 patients with neutrocytic ascites and/or positive ascitic fluid (AF) culture while group (2) included 22 patients with culture negative non neutrocytic ascites (CNNNA), recruited as controls. AF and urine samples were collected from all studied participants. ELISA kit was used for measurement of NGAL levels in AF and urine. DNA extraction and PCR were done.
Results: Values of NGAL in ascitic fluid were statistically significantly higher in bactDNA positive group. At cutoff 143.9 ng/ml, ascites NGAL had 86.4% sensitivity, 45.5% specificity, 61.3% positive predictive value (PPV) and 76.9% negative predictive value (NPV). When comparing ascites NGAL between bactDNA positive and negative group, NGAL has a sensitivity of 86.2% and a specificity of 46.7%, PPV of 75.8%, NPV of 63.6%. As for urine NGAL, patients with AKI had statistically significant higher levels of NGAL. Urine NGAL achieved sensitivity of 77.3%, specificity of 50%, PPV of 60.7%, NPV of 68.75%.
Conclusion: Early and accurate diagnosis of BT or bactDNA translocation can be aided by utilizing NGAL especially in ruling out infection in those reported to have negative culture results, besides, it can help in early detection of complication of cirrhosis and infection especially AKI helping in the improving the prognosis of cirrhotic patients. It is an advantage that a single marker can detect both infection and kidney injury.
Conservative management of post‐operative peritoneal cysts associated with endometriosis
Authors: Takeuchi K , Kitazawa S , Kitagaki S , Maruo T 
Published: July 2002

AbstractObjective: To describe the usefulness of fine‐needle aspiration cytology and drainage, followed by long‐acting GnRH‐agonist therapy in the management of post‐operative peritoneal cysts with endometriosis. Methods: In six women who were diagnosed as having post‐operative peritoneal cysts with endometriosis, fine‐needle aspiration cytology and drainage was performed. Thereafter, four patients were treated with long‐acting GnRH‐agonists for 6 months. Two patients refused the treatment. Results: In all patients fine‐needle aspiration yielded specimens which consisted of a population of mesothelial cells. The mean follow‐up time was 4 years (range 3.5–5). The four patients treated with long‐acting GnRH‐agonists show no evidence of recurrence. In two patients who had no additional treatment, the recurrence of the cyst was noted 2 months and 5 months after the drainage. Conclusion: Combination of fine‐needle aspiration cytology and drainage and subsequent long‐acting GnRH‐agonist therapy can be a useful conservative management of post‐operative peritoneal cysts associated with endometriosis.
Human papillomavirus (HPV) DNA assay as an adjunct to liquid‐based Pap test in the diagnostic triage of women with an abnormal Pap smear
Authors: Vassilakos P. , de Marval F. , Muñoz M. , Broquet G. , Campana A. 
Published: July 2002

AbstractObjective: The diagnostic performance and clinical value of the combined use of liquid‐based Pap test and human papillomavirus testing were determined in 336 patients with a previous abnormal smear. Method: Subsequent histologic evaluation was used as definitive diagnosis. Result: The combined use of liquid‐based Pap test and HPV DNA testing showed higher rates in sensitivity (99.0%), specificity (59.3%), positive predictive value (89.9%) and negative predictive value (94.5%) than either cytology alone (sensitivity 98.8%, specificity 45.7%, positive predictive value 84.7%, negative predictive value 92.6%) or HPV DNA testing alone (sensitivity 84.9%, specificity 67.4%, positive predictive value 88.8%, negative predictive value 59.5%). Conclusion: The study demonstrated that the diagnostic accuracy for cervical cancer and its precursors was improved by using the liquid‐based Pap test as a primary diagnostic procedure and HPV assay as an adjunctive test. This information may assist the clinicians in triaging patients with equivocal cytologic cervical atypias.
Transvaginal color Doppler ultrasonography and CA‐125 in suspicious adnexal masses
Authors: Alcázar J.L. , Errasti T. , Zornoza A. , Mı́nguez J.A. , Galán M.J. 
Published: July 2002

AbstractObjective: To compare diagnostic performance of color Doppler ultrasound and CA‐125 in suspicious adnexal masses on B‐mode sonography. Materials and methods: Data on 94 patients (mean age: 47.4 years, range: 17–79 years. Fifty‐two (55.3%) premenopausal and 42 (44.7%) postmenopausal women) managed in our institution because of a suspicious adnexal mass were reviewed. All patients were evaluated by transvaginal color Doppler ultrasonography (CD) and serum CA‐125 level determination prior to surgery. Definitive histopathological diagnosis was obtained in each case. Sonographic morphology evaluation was suspicious in all cases. CD was considered as suspicious when flow was detected and the lowest RI found was ≤0.45. CA‐125 cut‐off was ≥35 UI/ml. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each method and compared. ROC analysis was performed for RI and CA‐125. Areas under curve (AUC) were calculated and compared. Results: Fifty‐six (59.6%) tumors were found to be malignant and 38 (40.4%) benign. Sensitivity, specificity, PPV and NPV for CD were 87.5% (95% CIs: 75.3–94.4), 84.2% (95% CIs: 68.7–94), 89.1% (95% CIs: 77.7–95.9) and 82.1% (95% CIs: 66.5–92.5), respectively. Sensitivity, specificity, PPV and NPV for CA‐125 were 83.9% (95% CIs: 71.7–92.4), 68.4% (95% CIs: 51.3–82.5), 79.7% (95% CIs: 66.2–89) and 74.3% (95% CIs: 56.7–87.5), respectively. Sensitivity, PPV and NPV were not statistically different. CD had higher specificity (P=0.01). AUC curve for Doppler (0.75) was significantly higher than for CA‐125 (0.61) (P=0.0002). Conclusions: Our results indicate that color Doppler ultrasound has a better diagnostic performance as compared with CA‐125, being significantly more specific.
Advanced manufacturing technologies and strategically flexible production
Authors: Cagliano Raffaella , Spina Gianluca 
Published: July 2002

AbstractThis paper deals with the role of advanced manufacturing technologies (AMT) within the context of changes in the basic principles to organize and manage manufacturing systems. In particular, the use and effectiveness of various technologies and their computer‐based integration are investigated in the light of three emerging principles: (i) strategic multi‐focusedness, (ii) process integration across functions, and (iii) process ownership. Together, these principles are referred to as Strategically Flexible Production (SFP). In an international sample of 392 manufacturing units from the metal‐working industry, the use of AMT is analyzed in three groups: core adopters, partial adopters or non‐adopters of SFP. Data show that while core adopters do not use stand‐alone AMT more than the other groups, they have a higher level of computer integration (CI), in particular in their forefront departments. However, the use of integrating technologies varies much within the core adopters, suggesting that SFP does not necessarily require massive information technology (IT) support. This is further confirmed by the analysis of performance improvements. The mere adoption of stand‐alone AMT per se does not provide companies with superior improvements in performance. On the contrary, SFP alone or combined with a higher level of integration of stand‐alone AMT fosters increased time responsiveness.
Expression of amyloid precursor protein mRNA isoforms in rat brain is differentially regulated during postnatal maturation and by cholinergic activity
Authors: Apelt Jenny , Schliebs Reinhard , Beck Mike , Roiner Steffen , Bigl Volker 
Published: July 2002

AbstractPathological processing of the amyloid precursor protein (APP) is assumed to be responsible for the amyloid deposits in Alzheimer‐diseased brain tissue, but the physiological function of this protein in the brain is still unclear. The aim of this study is to reveal whether the expression of different splicing variants of APP transcripts in distinct brain regions is driven by postnatal maturation and/or regulated by cortical cholinergic transmission, applying quantitative in situ hybridization histochemistry using 35S‐labeled oligonucleotides as specific probes to differentiate between APP isoforms. In cortical brain regions, the expression of both APP695 and APP751 is high at birth and exhibits nearly adult levels. The developmental expression pattern of cortical APP695 displays a peak value around postnatal day 10, while the age‐related expression of APP751 demonstrates peak values on postnatal days 10 and 25, with the highest steady state levels of APP751 mRNA on day 25. During early development, the cortical laminar distribution of the APP695, but not APP751, mRNA transiently changes from a more homogeneous distribution at birth to a pronounced laminar pattern with higher mRNA levels in cortical layer III/IV detectable at the age of 4 days and persisting until postnatal day 10. The distinct age‐related changes in cortical APP695 and APP751 mRNA levels reflect the functional alterations during early brain maturation and suggest that APP695 might play a role in establishing the mature connectional pattern between neurons, whereas APP751 could play a role in controlling cellular growth and synaptogenesis.Lesion of basal forebrain cholinergic system by the selective cholinergic immunotoxin 192IgG‐saporin resulted in decreased levels of APP695 but not APP751 and APP770 transcripts by about 15–20% in some cortical (cingulate, frontal, parietal, piriform cortex), hippocampal regions (CA1, dentate gyrus), and basal forebrain nuclei (medial septum, vertical limb of diagonal band), detectable not earlier than 30 days after lesion and persisting until 90 days postlesion, suggesting that the nearly complete loss of cortical cholinergic input does not have any significant impact on the expression of APP mRNA isoforms in cholinoceptive cortical target regions.
DSM-IV catatonic features among psychiatric inpatients: a preliminary study
Authors: Oulis P , Lykouras L , Tomaras V , Panayotopoulou V , Gournellis R , Stefanis C 
Published: July 2002

SummaryWe studied DSM-IV catatonic features in 120 psychiatric inpatients with a main diagnosis of acute psychotic, affective or cognitive disorder. Individual catatonic features were highly intercorrelated, although diagnostically nonspecific. A single factor, accounting for 85% of the variance, was extracted and interpreted as representing both types (excited and retarded) of catatonic syndrome.
Discriminant cognitive factors in responder and non-responder patients with schizophrenia
Authors: Stip E. , Lussier I. , Ngan E. , Mendrek A. , Liddle P. 
Published: July 2002

SummaryTo identify which improvements in cognitive function are associated with symptom resolution in schizophrenic patients treated with atypical antipsychotics. Design: a prospective open trial with atypical neuroleptics (risperidone, clozapine, quetiapine). Setting: Inpatient and outpatient units, Institute of Psychiatry. Patients: Thirty-nine patients with schizophrenia according to DSM-IV criteria were included. Clinical and cognitive assessment were done at baseline (T0) and again after six months of treatment (T2). Twenty-five patients completed the trial. Interventions: New-generation antipsychotics during six months. Patients were considered as responders if their PANSS score decreased at least 20% (n= 15) and non-responders if it did not (n= 10). Outcome measures: a computerized cognitive assessment comprised tests of short-term-memory (digit span), explicit long-term memory (word pair learning), divided attention, selective attention and verbal fluency (orthographic and semantic). Clinical assessment included PANSS and ESRS. Results: A discriminant function analysis was performed to determine which changes in cognitive performance predicted symptomatic response status. Semantic fluency and orthographic fluency were significant predictors. Together they correctly predicted responder status in 88% of cases. Memory was not a significant predictor of symptomatic response. Conclusion: Verbal fluency discriminated the responder from the non-responder group during a pharmacological treatment.
Cognitive Screening Tools
Authors: Gulick Sarah H. , Mandel Steven , Maitz Edward A. , Brigham Christopher R. , Direnfeld Lorne K. 
Published: May 2021

Abstract
Physicians performing impairment evaluations on patients with cognitive complaints and possible central nervous system disorders should perform a clinical mental status assessment. Assessing cognitive complaints efficiently, in a systematic and supportable way, can be challenging. The AMA Guides to the Evaluation of Permanent Impairment specifies that objective criteria are important to consider when assessing impairment. Physicians may choose to use standardized cognitive screening tests (cognitive screeners) as a relatively quick, practical tool to initially assess patients and aid in decision making. Several cognitive screeners will be discussed in detail below. A patient's performance on such tests may indicate that more comprehensive testing is needed. Cognitive screeners have limitations and are not designed to assess symptom validity or the extent to which psychological factors may contribute to cognitive complaints. Comprehensive neuropsychological assessment may be indicated in these situations and when the screeners demonstrate findings of potential concern help define MMI.
Environmental Impact and Aging Properties of Natural and Synthetic Transformer Oils under Electrical Stress Conditions
Authors: Kurzweil Peter , Schell Christian , Haller Rainer , Trnka Pavel , Hornak Jaroslav 
Published: May 2021

AbstractAgainst the background of environmental compatibility and unrestricted technical usability, synthetic, and natural transformer oils are critically compared in long‐term tests under high voltage using electrical and instrumental analytical methods. Synthetic alkyl esters of pentaerythrol appear to be sustainable and sometimes superior substitutes for mineral oils in terms of chemical stability, viscosity, permittivity, and heat transport. Natural esters of unsaturated fatty acids are found to be unsuitable for equipment exposed to moist air. Adsorbed water appears to be a general problem in transformer oils. The aging mechanisms and molecular changes during long‐term operation include radical reactions, and the formation, isomerization and cleavage of CC bonds. Extensive material data are provided.
Hypothesis: JNK signaling is a therapeutic target of neurodegenerative diseases
Authors: Zhao Yingying , Kuca Kamil , Wu Wenda , Wang Xu , Nepovimova Eugenie , Musilek Kamil , Wu Qinghua 
Published: May 2021

AbstractThe exact signaling leading to neurological dysfunction in neurodegenerative diseases is currently unknown. We hypothesize that the c‐Jun N‐terminal kinase (JNK) signaling pathway is a potential therapeutic target for neurodegenerative diseases. This postulate rests on extensive data from cell and animal experimental studies, demonstrating that JNK signaling plays a crucial role in the pathogenesis of neurodegenerative diseases. The sustained activation of JNK leads to synaptic dysfunction and even neuronal apoptosis, ultimately resulting in memory deficits and neurodegeneration. JNK phosphorylates the amyloid precursor protein and tau, ultimately resulting in the formation of extraneuronal senile plaques and intraneuronal neurofibrillary tangles. Our hypothesis could be validated by investigating the cerebral cortex of elderly chimpanzees injected with phosphorylated JNK or transgenic pig and chimpanzee models established using gene editing technology including CRISPR. This hypothesis provides clues for further understanding the molecular mechanisms of neurodegenerative diseases and the development of potential target therapeutic drugs.
Tau pathologies mediate the association of blood pressure with cognitive impairment in adults without dementia: The CABLE study
Authors: Hu Hao , Meng Li , Bi Yan‐Lin , Zhang Wei , Xu Wei , Shen Xue‐Ning , Ou Ya‐Nan , Ma Ya‐Hui , Dong Qiang , Tan Lan , Yu Jin‐Tai 
Published: May 2021

AbstractIntroductionThis study delineated the interrelationships among blood pressure (BP), cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), and cognition.MethodsThe linear regression analyses were conducted in 1546 non‐demented participants (mean age of 61.58 years, range 40 to 89 years; 40% female; average days of BP measurement, 9.10 days). Mediation analyses with 10,000 bootstrapped iterations were used to explore the mediation effects.ResultsA clear age‐related pattern of BP was delineated. Mid‐life hypertension (especially systolic BP), late‐life lower diastolic BP, as well as mid‐ and late‐life higher pulse pressure were associated with cognitive impairment and tau‐related biomarkers. BP variability was associated only with cognition but not with CSF biomarkers. Overall, the associations between BP and cognition were partially mediated (proportion: 11% to 30%) by tau pathologies, independently of amyloid pathology.DiscussionTau pathologies might play important roles in the relationship between BP and cognition, with significant age‐ and BP‐type dependences.
Inorganic Synthesis Based on Reactions of Ionic Liquids and Deep Eutectic Solvents
Authors: Zhang Tao , Doert Thomas , Wang Hui , Zhang Suojiang , Ruck Michael 
Published: May 2021

AbstractIonic liquids and deep eutectic solvents are of growing interest as solvents for the resource‐efficient synthesis of inorganic materials. This Review covers chemical reactions of various deep eutectic solvents and types of ionic liquids, including metal‐containing ionic liquids, [BF4]−‐ or [PF6]−‐based ionic liquids, basic ionic liquids, and chalcogen‐containing ionic liquids. Cases in which cations, anions, or both are incorporated into the final products are also included. The purpose of this Review is to raise caution about the chemical reactivity of ionic liquids and deep eutectic solvents and to establish a guide for their proper use.