bluuebunny/crossref_metadata_2025_split huggingface dataset:
A conceptual framework of student professionalization for health professional education and research
Authors: Bélisle Marilou , Lavoie Patrick , Pepin Jacinthe , Fernandez Nicolas , Boyer Louise , Lechasseur Kathleen , Larue Caroline 
Published: March 2021

Abstract

Objectives
To present a conceptual framework of student professionalization for health professional education and research.

Methods
Synthesis and discussion of a program of research on competency-based education.

Results
Competency-based education relies on active, situation-based group learning strategies to prepare students to become health professionals who are connected to patient and population needs. Professionalization is understood as a dynamic process of imagining, becoming, and being a member of a health profession. It rests on the evolution of three interrelated dimensions: professional competencies, professional culture, and professional identity. Professionalization occurs throughout students’ encounters with meaningful learning experiences that involve three core components: the roles students experience in situations bounded within specific contexts. Educational practices conducive to professionalization include active learning, reflection, and feedback.

Conclusions
This conceptual framework drives a research agenda aimed at understanding how students become health professional and how learning experiences involving action, reflection, and feedback foster that process and the advancement of professional practices.
Clinical features of hypertensive patients with COVID-19 compared with a normotensive group: Single-center experience in China
Authors: Wang Shuang , Zhang Qiang , Wang Peng , Ye Huahong , Jing Xiaoqing , Zhang Zhongdan , Zhu Shisheng , Luo Tingting , Zheng Zhaobin 
Published: March 2021

Abstract

Background
SARS-CoV-2 has spread worldwide and poses a great threat to human health. Among COVID-19 patients, those with hypertension have been reported to have higher morbidity and mortality. This study was conducted to provide the international community with a deeper understanding of COVID-19 with hypertension.

Methods
A total of 623 COVID-19 patients enrolled in Wuhan’s hospital were studied from January to March 2020. The epidemiology, clinical features, and laboratory data of hypertensive patients with COVID-19 were collected, retrospectively analyzed, and compared with a normotensive group. The use of antihypertensive drugs, general treatment, and clinical outcomes of hypertensive patients were also analyzed.

Results
The median ages in hypertensive patients with mild and severe COVID-19 were both significantly greater than the median age in the normotensive group. But there was no significant gender difference between the hypertensive and normotensive groups. All patients had lived in Wuhan area. Common symptoms of all patients included fever, cough, and fatigue. Chest computed tomography (CT) scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients. All (315 (100%)) of the hypertensive patients received antiviral therapy (Umifenovir was used alone or in combination with Ribavirin), antibiotic therapy (215 (68.3%)), and corticosteroids (118 (37.5%)). The results suggest that the combination of Umifenovir and Ribavirin as initial therapy for hypertensive patients with COVID-19 is effective and safe. There were no significant differences in laboratory data between the mild cases in the hypertensive and the normotensive groups. In the severe cases, the hypertensive patients had higher plasma levels of D-dimer, C-reactive protein (CRP), and Interleukin-6 (IL-6) (P < 0.05). Furthermore, the hypertensive patients who were treated with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) were not represented in a statistically significant manner between the mild and severe groups (p > 0.05).

Conclusion
In this study, we demonstrated that the hypertensive patients who were treated with ACEI/ARB did not have an increased risk of developing severe COVID-19. Umifenovir and Ribavirin played an important role in the treatment of viral pneumonia. Hypertensive patients with severe viral pneumonia had stronger inflammatory responses than nonhypertensive patients.
Crystal structure of 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one, C14H13NO
Authors: Ke Yu-Jing , Liang Peng-Jie , Wang Peng-Cheng , Xian Shao-Hua , Li Guo-Qiang 
Published: March 2021

Abstract
C14H13NO, monoclinic, P21/n (no. 14), a = 9.2770(7) Å, b = 8.4582(6) Å, c = 13.4430(12) Å, β = 98.199(8)°, V = 1044.05(14) Å3, Z = 4, R

gt
(F) = 0.0484, wR

ref
(F
2) = 0.1151, T = 100 K.
Out-of-Sample Predictability of Economic Efficiency Measures of U.S. Banks: Evidence of Capital Adequacy Requirements
Authors: Sakouvogui Kekoura 
Published: March 2021

Abstract
This paper contributes to the sparse debate on the effect of capital adequacy requirements on banks’ economic efficiency measures. Precisely, we evaluate the out-of-sample predictability of capital adequacy requirements on banks’ economic efficiency measures using Support Vector Regression (SVR) model with Linear, Polynomial and Radial Basis Function kernels and ordinary least squares (OLS) model. This analysis is important because a prediction of economic efficiency measures allows for an untangle view of bank’s progress that is useful for management as it gains a high degree of transparency in the evaluation of future events. Our framework adapts optimization of h-block cross-validation to account for serial correlation of economic variables to produce robust sets of tuning parameters for SVR model. Using a total of 10,380 December quarterly observations of U.S. Commercial and Domestic banks spanning from 2008 through 2019, empirical results show that SVR model provides better benchmarking insights in the evaluation of economic efficiency measures compared to the OLS model. Furthermore, in contrast to previous approaches identifying a single “best” model among competing models, the results of Model Confidence Test suggests that the out-of-sample forecasting confidently identifies superior predictive accuracy of SVR model-based forecasts over OLS model.
Récurrence ipsilatérale de la neuropathie optique ischémique antérieure non artéritique : Rapport de cas
Authors: Brigham Daniel 
Published: March 2021

Résumé
La neuropathie optique ischémique antérieure non artéritique (NOIA-NA) est une maladie multifactorielle qui constitue le type le plus courant de neuropathie optique ischémique. La NOIA-NA apparait dans un oeil et peut se développer plus tard dans l’autre oeil. La récurrence ipsilatérale de la NOIA-NA est rare et plusieurs théories ont été proposées pour l’expliquer. Le présent rapport de cas décrit un patient chez qui une récurrence unilatérale de la NOIA-NA est survenue, examine les étiologies proposées et met l’accent sur les symptômes visuels à la suite de sa résolution.
PROMOSI DAN PUBLIC RELATION DI PERPUSTAKAAN
Authors: Lubis Nazrul Rizal , Gunawan Arief , Darwanto Darwanto 
Published: March 2021

ABSTRAKFungsi utama penyelenggaraan perpustakaan adalah pelayanan. Dalam menjalankan fungsi pelayanan tersebut, public relations (PR) memiliki peran yang sangat penting. PR berfungsi sebagai pendukung manajemen, membangun citra perpustakaan, dan sebagai komunikator. Artikel ini mengetengahkan prinsip-prinsip PR yang perlu diimplementasikan pada perpustakaan dan berbagai upaya yang perlu dilakukan untuk meningkatkan pelayanan dan membangun pencitraan perpustakaan. ABSTRACTLibrary service is the main function of a library. Public relations (PR) is one of factors determining the function. PR has functions as management support, building library image, and as communicator. This article sheds light on PR principles that should be implemented at library and several efforts which should be conducted in improving library service and library image.
KEBERLANJUTAN PERPUSTAKAAN DAN KEPUSTAKAWANAN di LINGKUNGAN LIPI KAWASAN JAKARTA
Authors: Rahayu Rochani Nani , Royani Yupi 
Published: March 2021

Di lingkungan Lembaga Ilmu Pengetahuan Indonesia (LIPI) terdapat perpustakaan yang berada pada masing – masing satuan kerja. Dalam beberapa tahun ini keberadaan perpustakaan di lingkungan satuan kerja LIPI mulai dipertanyakan dan dipermasalahkan karena pemustaka yangdatang secara langsung sudah mulai berkurang. Penelitian ini bertujuan untuk mengetahui persepsi kepala satuan kerja serta para peneliti di lingkungan LIPI Kawasan Jakarta tentang keberadaan dan keberlanjutan perpustakaan dan kepustakawanan di lingkungan LIPI Jakarta. Digunakan metode kualitatif dilengkapi dengan wawancara mendalam. Penelitian dilakukan terhadap Kepala Satuan Kerja serta para peneliti di lingkungan LIPI Jakarta, meliputi PDDI, Pusat Penelitan Politik, Pusat Peneltian Ekonomi, Pusat Penelitian Kemasyarakatan dan Kebudayaan, Pusat Penelitian Kependudukan, LIPI Press, Pusat Penelitian Oseanografi, Pusat Kebijakan dan Manajemen Iptek dan Inovasi dengan jumlah responden sebanyak 30 orang. Hasil dan kesimpulan menunjukkan bahwa Perpustakaan tetap diperlukan, karena informasi yang ada di perpustakaan merupakan harta kekayaan intelektual yang harus dipelihara dan dilestarikan agar bisa diwariskan untuk generasi mendatang serta dikembangkan agar didapat kekayaan intelektual yang baru. Namun disarankan agar perpustakaan dilengkapi dengan, sarana dan prasarana yang lengkap dan nyaman, serta diharapkan pustakawan meningkatkan kompetensi agar dapat memberikan layanan dengan lebih baik. Within the Indonesian Institute of Sciences (LIPI) there are libraries located in each work unit. In recent years the existence of libraries in the LIPI work unit environment has begun to be questioned and questioned because users who come directly have begun to decrease. This study aims to determine the perceptions of the head of the work unit as well as researchers in the JakartaLIPI environment about the existence and sustainability of libraries and librarians in the Jakarta LIPI environment. Used a qualitative method supplemented with in-depth interviews. The study was conducted on the Head of the Work Unit and researchers in the LIPI Jakarta, including the Center for Scientific Data and Documentation, the Center for Political Research, the Center for Economic Research, the Center for Community and Cultural Research, the Center for Population Research, LIPI Pressm,the Center for Oceanographic Research, the Center for Policy and Management Science and Innovation with 30 respondents. The results and conclusions show that the Library is still needed, because the information in the library is intellectual property that mustbe preserved and preserved so that it can be inherited for future generations and developed in order to obtain new intellectual property. However, it is recommended that the library be equipped with complete and convenient facilities and infrastructure, and it is hoped that librarians will increase their competence in order to provide better services.
Editorial
Authors: Mascarenhas Marcello Ávila 
Published: March 2021

A revista Ciência em Movimento - Reabilitação e Saúde apresenta um caráter interdisciplinar e com classificação no Qualis A4, da CAPES. Vem nesses últimos 15 anos promovendo difundir a reabilitação e inclusão em saúde, sobre diversos aspectos da vida. É nesse propósito que nossa revista e autores colidimos com obstáculo essencial no hábitoda leitura com temas incluídos, como fenômenos em termos de estratégia de remodelação, causalidade e correlação com temas atuais.Sendo assim, esta edição também apresenta 11 temas abordando “curvatura sagital da coluna”, “treinamento muscular pélvico”, “parâmetros de vitamina D”, “avaliação do consumo alimentar para eventos cardiovasculares”, “nível de atividade física entre escolares”, “obesidade central”, “ansiedade e dança”, “coronavírus”, “doenças lisossômicas”, “qualidade de registros” e “saúde dos competidores de tênis seniores”. Essa variedade de assuntos é característicada possibilidade de se colocar diante da fragilidade do indivíduo ou da doença, processo contínuo, impulsionado por avanços do conhecimento e atualizações das práticas de atenção à saúde, enfatizando a condição desujeito, possibilitando um novo olhar ao longo do processo de reabilitação.O compartilhamento de conhecimento sofre a influência de inúmeras variáveis, que podem impactar esse processo de diferentes formas. O grande obstáculo está exatamente no aspecto: muitas vezes o conhecimento a ser compartilhado envolve vocabulário inovador. Segundo Sveiby (1998) descreve que “o significado que uma pessoaexpressa nunca é o mesmo que aquele gerado na mente da pessoa que o recebe”.Retomando os nossos propósitos de reabilitação como busca de ser medidas apropriadas para permitir que a ciência alcancem e mantenham o máximo de independência, sua mais completa capacidade biológica, psicológica, social e vocacional sobre todos os aspectos da vida. E quando pensamos causalidade, considerando pontos casuais que necessitam de controvérsias para elaboração de um ponto comum e por fim temas atuais que tornam-se um desafio para nossos dias como a pandemia causada por SARS-Cov-2 seus impactos.Desejamos a todos uma ótima leitura!
Relationship of Flat Foot and Plantar Fascia Thickness in Medical Students of Pelita Harapan University
Authors: Taniwangsa Livia , M.T. Siahaan Yusak 
Published: March 2021

<p><strong>Background : </strong>Plantar fascia plays significant role in supporting the height and structure of Medial Longitudinal Arch (MLA). In flat foot, the MLA is depressed. There is thickening of plantar fascia reported in cases of plantar fasciitis in subjects with flat foot. Therefore, research needs to be done to investigate the relation between flat foot and plantar fascia thickness.</p><p><strong>Aim: </strong>To understand the relationship between flat foot and plantar fascia thickness among medical students of Pelita Harapan University.</p><p><strong>Methods : </strong>This study was conducted using cross-sectional method with sampling method of non-random consecutive sampling. Data was collected through examinations performed and adjustments are made using inclusion and exclusion criteria. Flat foot was determined using navicular drop test and plantar fascia thickness was assessed using ultrasonography measurement. Results were analyzed using SPSS 22.0 and statistically tested using Spearman’s rho test.</p><p><strong>Result : </strong>The analysis of the relationship between flat foot and plantar fascia thickness showed positive correlation with correlation coefficient of 0.634 on the right foot and 0.443 on the left.</p><p><strong>Conclusion : </strong>There is moderate and strong positive relationship between flat foot and plantar fascia thickness among medical students of Pelita Harapan University.</p>
Preliminary investigation of potent thiols in Cypriot wines made from indigenous grape varieties Xynisteri, Maratheftiko and Giannoudhi
Authors: Copper Alexander Willem , Collins Cassandra , Bastian Susan E. P. , Johnson Trent E. , Capone Dimitra L. 
Published: March 2021

Polyfunctional thiols have previously been shown to be key aroma compounds in Sauvignon blanc and more recently in Chardonnay wines. Their role in other wine varieties such as those made from three popular indigenous Cypriot grape varieties has remained unexplored. As an extension of a previous project that profiled the sensory and chemical characteristics of Cypriot wines and their comparison to Australian wines, this study aimed to investigate five potent thiols in Xynisteri, Maratheftiko, Giannoudhi, Pinot gris, Chardonnay and Shiraz wines.
Wines were analysed utilising Stable Isotope Dilution Assay (SIDA) with derivatisation and High-Performance Liquid Chromatography–Tandem Mass Spectrometry (HPLC-MS/MS). The varietal thiols measured were 4-methyl-4-sulfanylpentan-2-one (4MSP) that has an aroma of “boxwood” and “cat urine” at high concentration, 3-sulfanylhexan-1-ol (3SH) which has been described as having a “grapefruit/tropical fruit” aroma, and 3-sulfanylhexyl acetate (3SHA) that has also been described as having an aroma of “passionfruit”. Additionally, two other potent thiols were measured including benzyl mercaptan (BM) that has an aroma of “smoke and meat” and furfuryl thiol (FFT) that has been described as having a “roasted coffee” like aroma. The reason these thiols are known as potent thiols are due to their very low aroma detection thresholds in the low ng/L (ppt) range. Of the thiols that were measured, 3SH was the only varietal thiol detected in the red wine samples. All of the white wine samples contained 3SH, BM and 3SHA, whereas 4MSP was only detected in Pinot gris and three Xynisteri wines. The potent thiol, FFT, was detected only in the Chardonnay and four of the Xynisteri wines. Interestingly the thiols that were present in the samples were found at concentrations above their aroma detection thresholds (determined in hydroalcoholic solutions), especially 3SH which was found in an order of magnitude above its aroma detection threshold. These findings provide early knowledge of the presence of these thiols in Cypriot wines, compared with Australian wines and establish any relationships between this chemical data with previous wine sensory profile data.
A Signal-seeking Phase Iia Trial of Palbociclib in Advanced Cancers With Cell Cycle Pathway Alterations – A Substudy of the Molecular Screening and Therapeutics (Most) Program
Authors: Thavaneswaran Subotheni , Sebastian Lucille , Kansara Maya , Ballinger Mandy , Espinoza David , Lin Frank , Lee Chee , Sjoquist Katrin , Grady John , Cowley Mark , Joshua Anthony , Qiu Min , Oakes Samantha , Simes John , Thomas David 
Published: March 2021

Abstract
BACKGROUND: The D-type cyclin and cyclin dependent kinase 4/6 (CDK) complex phosphorylates retinoblastoma protein, thereby driving cell cycle progression. This process is blocked by inhibitors of CDK4/6. As part of the Molecular Screening and Therapeutics program, this phase IIa trial tested the clinical activity of CDK4/6 inhibitor monotherapy in tumors with cell cycle pathway alterations.PATIENTS AND METHODS: Eligible patients ≥ 18 years old, with advanced or metastatic solid cancers, along with amplification of CDK4/6, CCND1/2/3, or loss of function alterations in CDKN2A were recruited. The primary objective of this signal-seeking trial was to evaluate the clinical activity of palbociclib – a composite of objective responses and the ratio of time to progression (TTP) on palbociclib, to TTP on treatment preceding trial entry.RESULTS: Ten patients had CDK4/CDK6 or Cyclin D1 amplifications, six patients had CDKN2A deletions. After a median follow-up of 35 months, there were no objective responses. Seven patients had stable disease and one had non-complete response/non-progressive disease (non-CR/non-PD) based on evaluation of a non-target lesion. Two of these seven patients maintained stable disease for at least 6 months, as did the patient with non-CR/non-PD. Median PFS and OS were 3.5 and 11.0 months respectively. No unexpected toxicities were observed. Translational correlates yielded strategies for targeting cell cycle interactions with other molecular pathways and the immune system.CONCLUSION: Palbociclib monotherapy was not associated with any objective responses, but stable disease lasting at least 6 months was observed in 19% of patients. There was no clear relationship with alteration type or histotype. The signals of immune activation provide insights into the design of future trials, with a combination approach adding checkpoint blockade to CDK4/6 inhibition.
The Landscape of Iron metabolism-related Genes for Overall survival prediction in Patients with Hepatocellular Carcinoma
Authors: Zhu Zhipeng , Cao Huang , Huang Heqing , Zhan Hongliang , Liu Zhengsheng , Lu Kaihong , Zhang Ting , Miao Chaohao , Wu Zhun 
Published: March 2021

Abstract
Hepatocellular carcinoma (HCC) is the seventh most commonly occurring cancer and the second most common cause of cancer-related death worldwide. Despite improvements in early detection and treatment, the morbidity and mortality remain high because of complex molecular mechanisms and cellular heterogeneity in HCC. Immunotherapy therapies have been identified to be an effective treatment strategy for HCC. However, novel model is still needed to predict the survival and clinical immunotherapy response in HCC. Here we established a gene signature using iron metabolism-related genes form the Cancer Genome Atlas (TCGA), and the survival outcomes were validated from International Cancer Genome Consortium(ICGC). Distinct subtypes (high- and low-risk subtypes) were characterized by different clinical outcomes. The high-risk subtype was featured by better survival outcomes, upregulation of immune checkpoints expression, including programmed death-ligand 1 (PD-L1) expression, cytotoxic T-lymphocyte associated protein 4(CTLA-4) expression, T-cell immunoglobulin mucin 3(TIM-3) expression and T cell Ig and ITIM domain (TIGIT) expression, upregulated cell cycle relevant pathways and better response for immunotherapy. Thus our finding suggested that the novel model may be useful as a biomarker for prognostic predication, immunotherapy and cell cycle inhibitors may be efficacious for high-risk subtype of HCC patients.
Effects of Reducing PbO Content on the Elastic and Radiation Attenuation Properties of Germanate Glasses: A New Non-toxic Candidate for Shielding Applications
Authors: Buriahi M.S. Al- , Olarinoye I.O. , Mutuwong C. , Elsaeedy H. I. , Tonguç Barış Tamer 
Published: March 2021

Abstract
This work presents a detailed study on the effects of reducing PbO content on the elastic and radiation shielding properties of germanate glasses described by the chemical formula 50GeO2-(50-x)PbO-xZnO, where x between 0 and 50 mol % with step of 10. A theoretical analysis based on Makishima-Mackenzie's theory (MM-theory) was employed to obtain the elastic moduli of the studied glass specimens. Moreover, the Monte Carlo simulations were applied via Geant4 platform to assess the radiation shielding ability of the GeO2-PbO-ZnO glass system by evaluating several fundamental properties such as gamma and neutron transmission factors, total cross sections, effective atomic numbers, 1/e penetration depths, and exposure buildup factors. We found that the bulk elastic modulus increased from 50.751 GPa to 85.389 GPa as the PbO content increased from 50 mol % to 0. The results of the linear attenuation coefficient show that the cross sections of (σ)PE, (σ)CE, and (σ)pp dominates the photon attenuation at 0.15 ≤ E ≤ 0.08; 0.8 < E < 8, and 8 < E < 15 MeV respectively. Moreover, the present glasses have superior photon absorbing capacity compared to ordinary and barite concrete; RS-253-G18 and RS-360 commercial glass shields. This suggests that the GeO2-PbO-ZnO glass system can be used as a non-toxic shielding material in the nuclear facilities.