bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcoidose: relato de caso
Authors: Campos Roubert Igor , André dos Santos Vaz Ricardo 
Published: August 2021

Resumo:
Introdução: A sarcoidose é uma doença inflamatória multissistêmica de característica autoimune que acomete o pulmão em sua prevalência. Seu diagnóstico é obtido pela correlação clínico – radiológica positiva, além da ratificação histopatológica com o granuloma não caseoso, sua característica marcante. Possui etiologia ainda desconhecida, porém hipóteses sugerem uma reação granulomatosa inflamatória a partir da proliferação de linfócitos T CD4+ e outras células, devido ao contato com antígenos ambientais em indivíduos geneticamente predispostos ao seu desenvolvimento. É considerada uma doença rara e possui literatura escassa no Brasil. Objetivo: Relatar um caso de sarcoidose desde o diagnóstico até o tratamento, ampliando o conhecimento escasso sobre essa doença no Brasil. Material e método: As informações foram coletadas a partir da análise retrospectiva do prontuário, além de anamnese e exame físico da paciente confrontando os dados obtidos com a literatura atual, pesquisados em português e inglês na bases de dados PubMed, Scielo e Lilacs, dos anos de 2000 à 2019. Discussão: Houve correlação epidemiológica positiva com o perfil da paciente relatada, porém verificou-se um equívoco quanto a hipótese diagnóstica inicial com base na incompatibilidade da correlação clínico-histopatológica necessária para fechar o diagnóstico. Após nova biópsia houve melhor esclarecimento quanto a etiologia granulomatosa e confirmação do diagnóstico. Conclusão: Concluiu-se que a sarcoidose é pouco prevalente no Brasil e possui um polimorfismo grande sendo inclusa em muitos diagnósticos diferenciais de outras patologias prevalentes. Isso torna-a um desafio diagnóstico, que deve ser sempre considerada frente a manifestações clínicas inespecíficas.
PALAVRAS-CHAVE: Sarcoidose; Sarcoidose pulmonar; Doença de Besnier-Boeck.
Discovery of Structural Prospects of Imidazo[1,5-a]pyrazine Derivatives as BTK Inhibitors Against Cancer: A Computational Study
Authors: Ali Amena , Ali Abuzer , Ahsan Mohamed Jawed 
Published: August 2021

Background:
Bruton’s tyrosine kinase (BTK) plays an important role in cell development
and proliferation. BTK inhibitors are encouraging novel agents against B-cell malignancies and autoimmune
diseases. Although BTK inhibitors have been approved by the FDA to lower off-target effects
and reduce emerging resistances, it is necessary to develop novel BTK inhibitors with better
outcomes and minimum side effects.

Objective:
The present study includes pharmacophore hypothesis, 3D QSAR, virtual screening,
docking, ADME analysis, and screening of potential imidazo[1,5-a]pyrazine derivatives as BTK
inhibitors.

Methods:
Generation of pharmacophore hypothesis, virtual screening, 3D QSAR, molecular docking,
and ADME analysis were conducted.

Results:
The pharmacophore study generated 20 pharmacophore hypotheses as BTK inhibitors. The
five-point hypothesis DPRRR_1 was selected, consisting of one hydrogen bond donor, one positive
ionic, and three-ring aromatic features. 3D QSAR study of the compounds provided the best model
with high Q2 (0.8683), R2 (0.983), and R2CV (0.5338) values. The developed pharmacophore model
was further taken for screening of ZINC database ligands for evaluation of docking interaction and
physiochemical properties. Potent compounds of the series 15, 27, 8n, and 38 showed good docking
scores -8.567, -7.465, -6.922, -6.137, respectively.

Conclusion:
All the pharmacokinetic parameters analyzed, including human oral absorption of active
compounds of the series, were found to be within the permissible range. The present geometry
and features included in the pharmacophore hypothesis can be used for the development of novel
BTK inhibitors as anticancer agents.
Re-Interpretation of Mañjuśrī in Central and East Java
Authors: Pullen Lesley S 
Published: August 2021

This article will begin with a brief look at the origins of Mañjuśrī from south Nepal, his popularity in China and the many depictions of him in eastern India and Java. More importantly, it will re-interpret a selected group of the Boddhisattva Mañjuśri in the human form with one head and two arms. The statues produced in both bronze, silver and stone, all with similar attributes identifying him as Mañjuśrī. The theoretical framework follows the various representation of Mañjuśrī statues from eastern India to a Kumārabhūta form only in Central Java and a single form of Arapacana in East Java. Within this framework, it will evaluate the stylistic features, attributes and the sartorial style of statues from both regions of Java, with details not previously discussed by past scholars, particularly looking at the textile patterns found on several of the statues.When the Mañjuśrī statues appeared in Central Java, various forms of the youthful Kumārabhūta or royal prince emerged, where he appeared to be particularly popular. Despite past knowledge of these statues, this paper allows for a new research direction and highlights the change in Mañjuśrī styles from Central to East Java. Similarly, various forms of Mañjuśrī Arapacana from eastern India transpire in East Java with this one unique statue of Arapacana from Caṇḍi Jago.
Profil dan Persepsi Peminat Wisata Museum Nasional Sejarah Alam Indonesia di Kota Bogor
Authors: Rachim Sugiarti , Gunawan Hendra 
Published: August 2021

Lembaga Ilmu Pengetahuan Indonesia merevitalisasi Museum Etnobotani Indonesia menjadi Museum Nasional Sejarah Alam Indonesia (Munasain) dengan tujuan meningkatkan profesionalisme dalam diseminasi. Munasain merupakan salah satu obyek wisata di Kota Bogor, namun relatif belum banyak dikunjungi wisatawan dibandingkan Museum Zoologi dan Museum Tanah dan Pertanian. Penelitian ini bertujuan mengetahui profil dan persepsi peminat Munasain untuk mencari penyebab rendahnya kunjungan dan memberikan solusinya. Penelitian dilakukan dengan metode deskriptif menggunakan instrumen kuesioner yang disebarkan kepada 400 responden. Hasil penelitian menunjukkan bahwa peminat Munasain terbesar adalah kelompok umur 21-30 tahun (38,0%). Sebagian besar responden memperoleh informasi tentang Munasain dari media sosial (67,5%). Tema Munasain yang diminati adalah 38,6% tentang etnobotani, 32,3% koleksi sejarah dan budaya, 27,3% sejarah alam. Bagi responden Munasain dianggap istimewa dibanding museum lain karena merupakan sumber pengetahuan yang lengkap (31,2%), displaynya menarik (29,0%), dan memiliki unggulan koleksi etnobotani (18,3%). Tema yang diminati responden adalah sejarah alam dan budaya Indonesia (59,3%), etnobotani 38,7% dan tema lain 2,0%. Untuk pengembangan ke depan, 43,8% responden menyatakan perlunya sosialisasi dan promosi, 31,5% mengharapkan peningkatan manfaat bagi masyarakat, 16,0% menginginkan display lebih menarik dan 8,6% menyatakan perlunya penambahan koleksi.
Identifikasi Peran dan Koordinasi Pemangku Kepentingan Terhadap Pengembangan Sarana dan Prasarana di Atraksi Wisata Menara Siger, Kabupaten Lampung Selatan
Authors: Yusuf Mohamad , Sella Krisna 
Published: August 2021

Menara Siger merupakan atraksi wisata sekaligus ikon pariwisata Provinsi Lampung. Menara ini terletak di Bakauheni, Kabupaten Lampung Selatan dan dikelola oleh pemangku kepentingan yang beragam. Penelitian ini bertujuan untuk mengidentifikasi dan memaparkan bagaimana peran masing-masing pemangku kepentingan dalam pengembangan sarana dan prasarana di Menara Siger, serta upaya memaksimalkan koordinasi diantara pemangku kepentingan. Penelitian ini merupakan penelitian deskriptif kualitatif dengan pendekatan induktif. Pengambilan data dilakukan dengan menggunakan metode wawancara, observasi dan studi pustaka. Pemangku kepentingan terhadap pengembangan sarana dan prasarana di Menara Siger yang berhasil diidentifikasi meliputi pemerintah, pengunjung, lembaga nonpemerintah, industri/pelaku usaha pariwisata, akademisi, media dan masyarakat lokal. Penelitian ini menunjukan bahwa terdapat model koordinasi yang dilakukan diantara para pemangku kepentingan terhadap pengembangan sarana dan prasarana di Menara Siger. Dalam berkoordinasi, ditemukan pemangku-pemangku kepentingan yang berperan paling dominan yaitu pemerintah, lembaga nonpemerintah/lembaga swadaya masyarakat dan industri/pelaku usaha pariwisata. Ketiga pemangku kepentingan tersebut berperan dominan terhadap pengembangan sarana dan prasarana di Menara Siger disebabkan oleh kewenangan, pengaruh dan kepentingannya yang tinggi. Dalam menjalankan perannya, masing-masing pemangku kepentingan mempunyai kendala tersendiri. Namun demikian, kendala yang dialami saling berkaitan. Penelitian ini juga menunjukkan bahwa permasalahan yang umumnya terjadi adalah koordinasi tahap awal yang tidak berjalan dengan efektif, kurangnya komunikasi diantara para pemangku kepentingan, belum maksimalnya peran dari masing-masing pemangku kepentingan, serta proses pengambilan keputusan yang dinilai kurang tepat karena kurangnya keterlibatan seluruh pemangku kepentingan. Selain itu, terjadinya tumpang tindih peran dan fungsi pemangku kepentingan akibat intervensi pemerintah yang berperan sebagai pemangku kepentingan paling dominan.
ANTIMICROBIAL AGENT’S UTILIZATION AND COST PATTERN IN MEDICAL INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL
Authors: HUSSAIN SARTAJ , YADAV SURAJ SINGH , SAWLANI KAMAL KUMAR , USMAN KAUSER , KHATTRI SANJAY 
Published: August 2021

Objective: The objective of this study was to evaluate the utilization and cost pattern of AMAs (Antimicrobial Agents) in the Medical ICU of a tertiary care teaching hospital, and to determine the predictor of antimicrobial number per day.
Methods: A prospective cross-sectional study was carried out and a total of 101 patients were studied. The drugs were classified into different groups according to the World Health Organization’s ATC (Anatomical Therapeutic Chemical) Classification System.
Results: The mean [95% confidence interval (CI)] duration of ICU stay was 7.11 (5.70-8.52) days and the mortality rate in the ICU was 42.6%. The AMAs DDD (Defined Daily Dose) per 100 patient days and number of AMAs per prescription were 296.64 and 2.65, respectively. Piperacillin-tazobactam was the most commonly utilized AMAs followed by metronidazole, meropenem, fluconazole, and colistin. The mean number [95% CI] of AMAs, DDD, and cost (INR) per patient were 18.82 (14.05-23.59), 21.09 (15.36-26.81) and 25,827 (18,716-32,939) respectively. The AMAs constituted 88.53% of the total treatment cost. Meropenem was the most costly AMA (32.10% of the total AMAs cost) followed by imipenem-cilastatin (20.50%), colistin (14.65%), piperacillin-tazobactam (8.40%), and clindamycin (4.47%). The independent predictor for the antimicrobial number per day was acute physiology and chronic health evaluation II (APACHE-II) score at admission and nosocomial infections.
Conclusion: The AMAs, DDD per 100 patient days, and number per prescription were higher. This leads to a higher cost of AMAs per patient and the AMAs cost out of the total cost as compared to previous studies. We suggest, there is a need to formulate and implement an antimicrobial restriction policy.
Experiencia de violencia laboral en profesionales de enfermería de un hospital público
Authors: Cerda-Antilef S. , Rivas-Riveros E. , Campillay-Campillay M. 
Published: August 2021

Introducción: La violencia laboral en el entorno clínico es un tema emergente y de gran relevancia para los profesionales de enfermería, ya que afecta la eficiencia de los cuidados, y daña la salud de los profesionales que la sufren. A nivel global se ha evidenciado mayor violencia en entornos feminizados.
Objetivo: Comprender la experiencia de violencia laboral entre profesionales de enfermería hospitalarios durante el año 2017 en la ciudad de Valdivia, Chile.
Método: La investigación se aborda desde el paradigma interpretativo, metodología cualitativa y análisis de contenido de acuerdo a lo propuesto por Bardin. La muestra fue intencionada y se realizó entrevista en profundidad a diez profesionales de enfermería que habían experimentado violencia laboral y consintieron su participación. Se aplicaron preguntas orientadoras para conocer barreras y facilitadores de violencia.
Resultados: Emergen cuatro categorías: A) Percepción de clima organizacional asociado a estilos de liderazgo; B) Barreras contextuales y actitudinales asociadas a la aparición de conductas violentas (con las subcategorías: falta de colaboración, sobrecarga laboral, falta de procesos y pautas preventivas para la resolución de conflictos); C) Formas de violencia y acoso (con las subcategorías: difundir rumores laborales, persecución, retener información crucial y desautorización); y D) Fatiga de compasión. Se relaciona el fenómeno al modelo biomédico.
Conclusiones: El problema de violencia subyace a determinantes contextuales organizacionales que no dependen exclusivamente de los profesionales de enfermería, por lo que es urgente identificarlas, afrontarlas y prevenirlas.
Serological testing for SARS-CoV-2 antibodies in clinical practice: a comparative diagnostic accuracy study
Authors: Horn Michael , Jonsdottir Hulda R. , Brigger Daniel , Damonti Lauro , Suter-Riniker Franziska , Endrich Olga , Fröhlich Tanja , Fiedler Martin , Largiadèr Carlo , Marshall Jonas , Weber Benjamin , Eggel Alexander , Nagler Michael 
Published: August 2021

Background: Serological tests are a powerful tool in the
monitoring of infectious diseases and the detection of host immunity.
However, manufacturers often provide diagnostic accuracy data generated
through biased studies and the performance in clinical practice is
essentially unclear. Objectives: We aimed to determine the
diagnostic accuracy of various serological testing strategies for (a)
identification of patients with previous coronavirus disease-2019
(COVID-19) and (b) prediction of neutralizing antibodies against
SARS-CoV-2 in real-life clinical settings. Methods: We
prospectively included 2’573 consecutive health-care workers and 1’085
inpatients with suspected or possible previous COVID-19 at a Swiss
University Hospital. Various serological immunoassays based on different
analytical techniques (enzyme-linked immunosorbent assays, ELISA;
chemiluminescence immunoassay, CLIA; electrochemiluminescence
immunoassay, ECLIA; lateral-flow immunoassay, LFI), epitopes of
SARS-CoV-2 (nucleocapsid, N; receptor-binding domain, RBD; extended RBD,
RBD+; S1 or S2 domain of the spike [S] protein, S1/S2), and antibody
subtypes (IgG, pan-Ig) were conducted. A positive real-time PCR test
from a nasopharyngeal swab was defined as previous COVID-19.
Neutralization assays with live SARS-CoV-2 were performed in a subgroup
of patients to assess neutralization activity (n=201).
Results: The sensitivity to detect patients with previous
COVID-19 was ≥85% in anti-N ECLIA (86.8%) and anti-S1 ELISA (86.2%).
Sensitivity was 84.7% in anti-S1/S2 CLIA, 84.0% in anti-RBD+ LFI,
81.0% in anti-N CLIA, 79.2% in anti-RBD ELISA, and 65.6% in anti-N
ELISA. The specificity was 98.4% in anti-N ECLIA, 98.3% in anti-N
CLIA, 98.2% in anti-S1 ELISA, 97.7% in anti-N ELISA, 97.6% in
anti-S1/S2 CLIA, 97.2% in anti-RBD ELISA, and 96.1% in anti-RBD+ LFI.
The sensitivity to detect neutralizing antibodies was ≥85% in anti-S1
ELISA (92.7%), anti-N ECLIA (91.7%), anti-S1/S2 CLIA (90.3%),
anti-RBD+ LFI (87.9%), and anti-RBD ELISA (85.8%). Sensitivity was
84.1% in anti-N CLIA, and 66.2% in anti-N ELISA. The specificity was
≥97% in anti-N CLIA (100%), anti-S1/S2 CLIA (97.7%), and anti-RBD+
LFI (97.9%). Specificity was 95.9% in anti-RBD ELISA, 93.0% in anti-N
ECLIA, 92% in anti-S1 ELISA, and 65.3% in anti-N ELISA. Diagnostic
accuracy measures were consistent among subgroups.
Conclusions: The diagnostic accuracy of serological tests for
SARS-CoV-2 antibodies varied remarkably in clinical practice, and the
sensitivity to identify patients with previous COVID-19 deviated
substantially from the manufacturer’s specifications. The data presented
here should be considered when using such tests to estimate the
infection burden within a specific population and determine the
likelihood of protection against re-infection.
Evaluating the Impact of Stakeholder Engagement in a School-Based Type 1 Diabetes Study
Authors: March Christine A. , Kazmerski Traci M. , Moon Christine , Libman Ingrid M. , Miller Elizabeth 
Published: August 2021

Objective
Although the importance of stakeholder engagement (SE) for patient-centered research is recognized, few studies document SE processes and influence on research outcomes in the diabetes field. We applied a research-informed framework to evaluate the impact of SE on a pediatric diabetes study exploring school nurse perspectives on modern diabetes devices.

Methods
We recruited parents of children with type 1 diabetes, school nurses, and diabetes providers. Stakeholders convened virtually every 2 months for 12 months. Goals for SE included input on research materials, interpretation of findings, and future research directions. Processes were assessed using a validated survey. Immediate outcomes included changes to research materials and satisfaction. Secondary outcomes included research efficiency and value (acceptance by community partners).

Results
Each role was represented at every meeting. The majority of stakeholders (&gt;70%) completed the survey at study midpoint and end points. All surveyed indicated that they had received all desired information, shared feedback, and felt valued. Stakeholders were satisfied with the meeting frequency. Participants appreciated learning from each other and expressed enthusiasm for continued research participation. They described their role as one of consultant rather than research team members. SE resulted in five additional interview questions. Nearly 70 comments added to the interpretation of qualitative themes. Findings were published within 12 months and recognized by the state school nursing organization.

Conclusion
SE was well received and led to meaningful changes in content and dissemination of a diabetes study. A systematic approach to evaluating SE can increase scientific rigor and reproducibility and contribute to best practices for SE in diabetes research.
Kode Etik Pustakawan sebagai Aturan Profesional bagi Profesi Pustakawan
Authors: Nur’aini Nur’aini , Nasution Laila Hadri 
Published: August 2021

Penelitian ini bertujuan untuk memaparkan bagaimana kode etik pustakawan sebagai aturan profesional bagi profesi pustakawan. Metode penelitian ini menggunakan kajian literatur (Library Research) dari berbagai sumber terpercaya melalui buku, jurnal dan sumber tertulis lainnya yang mendukung pembahasan isi artikel penelitian ini. Hasil pembahasan ini bahwa kode etik pustakawan harus dipahami oleh anggota profesi, agar anggota profesi pustakawan dalam melaksanakan tugas selalu bersikap ramah, sopan santun dan suka menolong kepada pengguna, teman sejawat, anggota profesi yang lain dan masyarakat. Dengan isi yang terkandung didalam kode etik pustakawan diharapkan agar para anggota pustakawan dapat melaksanakan aturan yang tertulis dalam kode etik pustakawan dan mempraktikkan dalam melaksanakan tugas.
Evaluasi tiga sistem budidaya di lahan sempit pada budidaya dua kultivar bayam di Kota Bekasi
Authors: Mubarok Syariful , Ananda Salsabila Dwi , Farida Farida , Fadilah Ainun , Sudirja Rija 
Published: August 2021

AbstrakBudidaya sayuran pada lahan sempit di daerah perkotaan merupakan salah satu upaya pemerintah dalam mewujudkan ketahanan pangan. Tujuan dari penelitian ini adalah untuk mengetahui sistem budidaya tanaman bayam yang paling baik untuk diterapkan pada lahan sempit pekarangan di Kota Bekasi. Percobaan ini telah dilaksanakan pada bulan Agustus hingga September 2020 di areal pemukiman yang berlokasi di Jalan Caringin Raya, Kota Bekasi. Percobaan menggunakan metode Rancangan Acak Kelompok (RAK). Dua kultivar bayam, ‘Maestro’ dan ‘Mira’, dibudidayakan pada tiga sistem budidaya berbeda, yaitu konvensional, vertikultur, dan hidroponik rakit apung yang diulang sebanyak empat ulangan. Hasil penelitian menunjukkan bahwa penanaman bayam pada sistem hidroponik rakit apung menghasilkan pertumbuhan, hasil, kualitas hasil, serta pendapatan yang paling baik dibandingkan dengan sistem budidaya konvensional dan vertikultur.Kata kunci: Hidroponik, hortikultura, sayuran, vertikultur Abstract Vegetable cultivation on limited areas in urban is one of the government's efforts to obtain food security. The purpose of this study was to determine the best amaranth cultivation system to be applied in urban farming system likewise on limited areas in Bekasi City. This experiment was carried out from August to September 2020 in a densely inhabited living area located on Caringin Raya Street, Bekasi. The experiment used a Randomized Block Design. Two cultivars amaranth, ‘Maestro’ and ‘Mira’ were cultivated under treatment of three different cultivation. There were conventional system, verticulture system, and hydroponic floating raft, that repeated four times. The results showed that amaranth cultivation on the floating raft hydroponic produced the best growth, yield, yield quality, and revenue, compared to conventional and verticulture cultivation systems. Keywords: Hydroponic, horticulture, vegetables, verticulture.
PENDIDIKAN ISLAM DALAM PERSPEKTIF KECERDASAN JAMAK (MULTIPLE INTELLIGENCES)
Authors: Ansharullah Ansharullah 
Published: August 2021

AbstractThis research stems from a condition which was observed in Indonesian high school. In general the schools do not implement the principles of multiple intelligences comprehensively. Conversely, it is still impressed that the learning is still dominated by one intelligence based education, that is IQ which is cause and effect oriented eductional program. In line with that the learning is filled in the domain of cognition which is commonly oriented at the most basic level of mental development, in which the level of memorization activity is fulfilled the learning process. So that the complex intelligences of the learners’ do not develop optimally. This conditions produce that the Indonesian educational products are not optimal. So to improve the quality of education, it is necessary to develop the implementation of learning system which based on the impact of the findings of neuroscience into education, including the development of multiple intelligences (multiple intelligences) in high school level. This research is a qualitative research seeing from philosophical approach and perspective. Along with that, the method used is descriptive, analysis and interpretive. Through philosophical approaches researcher tries to describe the essence of the eight intelligences and their applications in the learning process. With the method of description and interpretation, it is expected to be able to find an interpretation of the concept of multiple intelligences in accordance with socio-religious background of students’. Then by using the analysis method, the application of these findings can be adjusted to the needs and potentials which is available at high school levelled education.