bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformation of baroclinic tidal waves in the conditions of the shelf of the Far Eastern seas
Authors: Kuznetsov P D , Rouvinskaya E A , Kurkina O E , Kurkin A A 
Published: December 2021

Abstract
This work is devoted to the study of the regimes of transformation of baroclinic tidal waves under the conditions of the Far Eastern seas within the framework of a fully nonlinear numerical model. Two sections were selected to study the features of wave dynamics – in the Sea of Okhotsk (Sakhalin Island shelf) and in the Bering Sea (near Cape Navarin). On the basis of the performed calculations, regional and seasonal features of the transformation of baroclinic waves and the structure of the flow induced by them were revealed. It is shown that the dynamics in the winter season is less intensive. The rotation effect on the formation of solibore in the studied conditions is analyzed. The obtained estimates of wave amplitudes and velocities are consistent with the published data of field observations in the Sea of Okhotsk. For the Bering Sea, the conditions are shown to be favorable for the generation of intensive internal waves, which indirectly confirms the hypothesis of influence of such waves on the formation of underwater sand dunes.
Boosted dielectric performance of organic–inorganic nanocomposites based on BaTiO3 via 2D TiO2 templates
Authors: Park Se Yeon , Jang Moonjeong , Song Wooseok , Lee Sun Sook , Yoon Dae Ho , An Ki-Seok 
Published: December 2021

Abstract
Organic–inorganic hybrid dielectrics composed of nanoscale ceramic fillers in polymer matrices have attracted considerable attention because they can overcome the inherent limitations such as the low dielectric constant, high dielectric loss, and low film density associated with mechanically flexible pristine polymer materials. Barium titanate (BaTiO3), a representative perovskite-based material with a high permittivity, is suitable for applications as nanofillers in nanocomposite dielectrics. X-ray diffraction combined with Raman analysis suggest that a two-step hydrothermal synthesis, which uses synthesized TiO2 nanosheets as a template, is an effective method for the synthesis of pure BaTiO3 nanoparticles compared with other methods. Ultrasonic treatment is employed to disperse BaTiO3 nanoparticles with different concentrations in polyvinyl alcohol (PVA) polymer, and the dielectric performance of the nanocomposite films has been examined. In this study, 20 wt% BaTiO3–PVA nanocomposite dielectric showed superior capacitance and dielectric constant performance, i.e. five times higher than that of the pristine PVA.
The Brunn-Minkowski Inequality and A Minkowski Problem for Nonlinear Capacity
Authors: Akman Murat , Gong Jasun , Hineman Jay , Lewis John , Vogel Andrew 
Published: December 2021

In this article we study two classical potential-theoretic problems in convex geometry. The first problem is an inequality of Brunn-Minkowski type for a nonlinear capacity,

Cap

A

,

\operatorname {Cap}_{\mathcal {A}},

where

A

\mathcal {A}

-capacity is associated with a nonlinear elliptic PDE whose structure is modeled on the

p
p

-Laplace equation and whose solutions in an open set are called

A

\mathcal {A}

-harmonic.

In the first part of this article, we prove the Brunn-Minkowski inequality for this capacity:
\[

[

Cap

A

⁡
(
λ

E
1

+
(
1
−
λ
)

E
2

)
]

1

(
n
−
p
)

≥
λ

[

Cap

A

⁡
(

E
1

)
]

1

(
n
−
p
)

+
(
1
−
λ
)

[

Cap

A

⁡
(

E
2

)
]

1

(
n
−
p
)

\left [\operatorname {Cap}_\mathcal {A} ( \lambda E_1 + (1-\lambda ) E_2 )\right ]^{\frac {1}{(n-p)}} \geq \lambda \, \left [\operatorname {Cap}_\mathcal {A} ( E_1 )\right ]^{\frac {1}{(n-p)}} + (1-\lambda ) \left [\operatorname {Cap}_\mathcal {A} (E_2 )\right ]^{\frac {1}{(n-p)}}

\]
when

1
>
p
>
n
,
0
>
λ
>
1
,

1>p>n, 0 > \lambda > 1,

and

E
1

,

E
2

E_1, E_2

are convex compact sets with positive

A

\mathcal {A}

-capacity. Moreover, if equality holds in the above inequality for some

E
1

E_1

and

E
2

,

E_2,

then under certain regularity and structural assumptions on

A

,

\mathcal {A},

we show that these two sets are homothetic.

In the second part of this article we study a Minkowski problem for a certain measure associated with a compact convex set

E
E

with nonempty interior and its

A

\mathcal {A}

-harmonic capacitary function in the complement of

E
E

. If

μ
E

\mu _E

denotes this measure, then the Minkowski problem we consider in this setting is that; for a given finite Borel measure

μ
\mu

on

S

n
−
1

\mathbb {S}^{n-1}

, find necessary and sufficient conditions for which there exists

E
E

as above with

μ
E

=
μ
.

\mu _E = \mu .

We show that necessary and sufficient conditions for existence under this setting are exactly the same conditions as in the classical Minkowski problem for volume as well as in the work of Jerison in \cite{J} for electrostatic capacity. Using the Brunn-Minkowski inequality result from the first part, we also show that this problem has a unique solution up to translation when

p
≠
n
−
1

p\neq n- 1

and translation and dilation when

p
=
n
−
1

p = n-1

.
Does Third-Party Intervention Matter? A Video-Based Analysis of the Effect of Third-Party Intervention on the Continuation of Interpersonal Conflict Behaviour
Authors: Ejbye-Ernst Peter 
Published: December 2021

Abstract
The article investigates whether third-party intervention influences the continuation of antagonist conflict behaviour in interpersonal conflicts. The analysis is based on a systematic coding of video footage of real-life conflicts from the streets of Amsterdam. A panel data analysis shows that intervention leads to discontinuation of conflict behaviour. The analysis furthermore finds that while physically forceful intervention stops conflict behaviour, expressions of disapproval have no noticeable effect. The social relationship between third parties and antagonists does not appear to matter for this effect. Third parties thus play an integral part in the development of interpersonal conflicts, but this influence depends on how they intervene. Future preventive efforts should emphasize that intervention works but must be performed in certain ways to be effective.
Infective endocarditis in pregnancy requiring simultaneous emergent caesarean section and mitral valve replacement: a case report
Authors: Maruichi-Kawakami Shiori , Nagao Kazuya , Kanazawa Takenori , Inada Tsukasa 
Published: December 2021

Abstract

Background
Although infective endocarditis (IE) in pregnancy is rare, maternal and foetal mortality rates are very high. We herein report the successful treatment of a case of IE with simultaneous emergent caesarean section and mitral valve replacement performed at 27 weeks of gestation.

Case summary
A 29-year-old woman at 27 weeks of gestation was referred for congestive heart failure (HF) due to infective endocarditis (IE) with large mobile vegetations and overt disruption of the mitral valve. We held a multi-disciplinary conference and decided to perform mitral valve replacement immediately after caesarean section because of the high risk of embolism and sepsis, worsening and unstable haemodynamics, and sufficient foetal maturity for delivery. Although coronary artery embolization and asymptomatic multiple cerebral infarctions were observed, her post-operative course was uneventful. Ultimately, the patient was discharged 29 days after surgery. The neonate was treated in the NICU until the expected delivery date and was discharged home on Day 95 of life.

Discussion
Difficulties are associated with the selection of an operative plan and its timing for IE during pregnancy. Heart failure due to IE requires urgent surgery when medical treatment cannot stabilize the patient. However, cardiopulmonary bypass and medicine for pregnant women adversely affect the foetus. Therefore, the timing of surgery and delivery needs to be selected by a multi-disciplinary team and in consideration of the maternal condition and foetal maturity.
Evidence for the agricultural origin of resistance to multiple antimicrobials in Aspergillus fumigatus, a fungal pathogen of humans
Authors: Kang S Earl , Sumabat Leilani G , Melie Tina , Mangum Brandon , Momany Michelle , Brewer Marin T 
Published: December 2021

Abstract
Pathogen resistance to clinical antimicrobial agents is an urgent problem. The fungus Aspergillus fumigatus causes 300,000 life-threatening infections in susceptible humans annually. Azoles, which are widely used in both clinical and agricultural settings, are currently the most effective treatment, but resistance to clinical azoles is emerging worldwide. Here, we report the isolation and analysis of azole-sensitive and azole-resistant A. fumigatus from agricultural environments in the southeastern United States (USA) and show that the USA pan-azole-resistant isolates form a clade with pan-azole-resistant isolates from the United Kingdom, the Netherlands, and India. We show that several pan-azole-resistant isolates from agricultural settings in the USA and India also carry alleles with mutations conferring resistance to agricultural fungicides from the benzimidazole (MBC) and quinone outside inhibitor (QoI) classes. We further show that pan-azole-resistant A. fumigatus isolates from patients in clinical settings in the USA, India, and the Netherlands also carry alleles conferring resistance to MBC and QoI agricultural fungicides. The presence of markers for resistance to agricultural-use fungicides in clinical A. fumigatus isolates is strong evidence for an agricultural origin of pan-azole resistance in patients. The presence of multiple fungicide-resistance alleles in agricultural and clinical isolates further suggests that the unique genetics of the pan-azole-resistant clade enables the evolution and/or persistence of antimicrobial resistance mutations leading to the establishment of multifungicide-resistant isolates.
Complete Genome Sequence of the Type Strain Tepidimonas taiwanensis LMG 22826T, a Thermophilic Alkaline Protease and Polyhydroxyalkanoate Producer
Authors: Hermankova Kristyna , Kourilova Xenie , Pernicova Iva , Bezdicek Matej , Lengerova Martina , Obruca Stanislav , Sedlar Karel 
Published: December 2021

Abstract
Tepidimonas taiwanensis is a moderately thermophilic, Gram-negative, rod-shaped, chemoorganoheterotrophic, motile bacterium. The alkaline protease producing type strain T. taiwanensis LMG 22826T was recently reported to also be a promising producer of polyhydroxyalkanoates (PHAs)—renewable and biodegradable polymers representing an alternative to conventional plastics. Here, we present its first complete genome sequence which is also the first complete genome sequence of the whole species. The genome consists of a single 2,915,587-bp-long circular chromosome with GC content of 68.75%. Genome annotation identified 2,764 genes in total while 2,634 open reading frames belonged to protein-coding genes. Although functional annotation of the genome and division of genes into Clusters of Orthologous Groups (COGs) revealed a relatively high number of 694 genes with unknown function or unknown COG, the majority of genes were assigned a function. Most of the genes, 406 in total, were involved in energy production and conversion, and amino acid transport and metabolism. Moreover, particular key genes involved in the metabolism of PHA were identified. Knowledge of the genome in connection with the recently reported ability to produce bioplastics from the waste stream of wine production makes T. taiwanensis LMG 22826T, an ideal candidate for further genome engineering as a bacterium with high biotechnological potential.
Phosphatidylserine Liposomes Reduce Inflammatory Response, Mycobacterial Viability, and HIV Replication in Coinfected Human Macrophages
Authors: Poerio Noemi , Caccamo Nadia R , La Manna Marco P , Olimpieri Tommaso , De Angelis Lucia Henrici , D’Andrea Marco M , Dieli Francesco , Fraziano Maurizio 
Published: December 2021

AbstractChronic immune activation is the key pathogenetic event of Mycobacterium tuberculosis-human immunodeficiency virus (HIV) coinfection. We assessed the therapeutic value of phosphatidylserine-liposome (PS-L) in an in vitro model of M. tuberculosis-HIV coinfection. PS-L reduced nuclear factor-κB activation and the downstream production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in bacille Calmette-Guérin-infected macrophages and of TNF-α and IL-1β in M. tuberculosis-infected and M. tuberculosis-HIV–coinfected macrophages. Importantly, a significant reduction of intracellular M. tuberculosis viability and HIV replication were also observed. These results support the further exploitation of PS-L as host-directed therapy for M. tuberculosis-HIV coinfection.
Real-life experience with bictegravir/emtricitabine/tenofovir alafenamide in a large reference clinical centre
Authors: Ambrosioni Juan , Rojas Liévano Jhon , Berrocal Leire , Inciarte Alexy , de la Mora Lorena , González-Cordón Ana , Martínez-Rebollar María , Laguno Montserrat , Torres Berta , Ugarte Ainoa , Chivite Iván , Leal Lorna , de Lazzari Elisa , Miró José M. , Blanco José L. , Martinez Esteban , Mallolas Josep 
Published: December 2021

Abstract

Background
The use of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) is mainly based on robust, pivotal clinical trials.

Objectives
To provide data on clinical use of BIC/FTC/TAF in real life.

Patients and methods
This was an observational, retrospective and single-centre study. We included all adult, treatment-naive (TN) and treatment-experienced (TE) people living with HIV (PLWH) starting BIC/FTC/TAF from 8 June 2018. We evaluated effectiveness [on treatment (OT), modified intention-to-treat (mITT) and intention-to-treat (ITT)], tolerability and safety in those patients who reached 6 months of follow-up (M6).

Results
We included 1584 PLWH [213 TN (13%) and 1371 TE (87%)]. The median (IQR) follow-up was 16 (7–21) months, with 81% and 53% of PLWH reaching M6 and M12, respectively. By OT, mITT and ITT, HIV-RNA &lt;50 copies/mL was 77%, 70% and 62% at M6 and 92%, 77% and 63% at M12 for TN PLWH and 94%, 89% and 83% at M6 and 93%, 85% and 78% at M12 for TE PLWH, respectively. In PLWH carrying an M184V/I substitution, OT RNA &lt;50 copies/mL was 89.5% at M6. The median CD4 cell count increased from 329 to 511/μL in TN PLWH and from 630 to 683/μL in TE PLWH at M6. Of the total, 1148 (88%) PLWH continued on BIC/FTC/TAF at M6. The most frequent known reason for discontinuation was toxicity [42 (69%) cases]; only 7 cases were considered virological failures (0.6% of the total OT cohort at M6), with no emerging resistance substitutions.

Conclusions
In real life, BIC/FTC/TAF showed high rates of virological suppression and also in PLWH carrying lamivudine/emtricitabine resistance substitutions. The tolerability and safety of BIC/FTC/TAF were good, with high persistence observed for patients on this regimen at M6.
Nutritional and functional values of lysedCorynebacterium glutamicumcell mass for intestinal health and growth of nursery pigs
Authors: Cheng Yi-Chi , Duarte Marcos Elias , Kim Sung Woo 
Published: December 2021

AbstractThe objective was to determine the nutritional and functional values of lysed Corynebacterium glutamicum cell mass (CGCM) as a protein supplement and a source of cell wall fragments supporting the growth and intestinal health of nursery pigs. Thirty-two pigs (21 d of age) were allotted to four treatments (n = 8) based on the randomized block design with sex and initial body weight (BW) as blocks. The main effect was the dietary supplementation of lysed CGCM (0, 0.7, 1.4, and 2.1%) replacing blood plasma and fed in two phases (10 and 11 d, respectively). Feed intake and BW were measured at the end of each phase. Pigs were euthanized on day 21 to collect jejunal tissue and mucosa to evaluate intestinal health. Ileal digesta were collected to measure the apparent ileal digestibility of nutrients in diets. Data were analyzed using Proc Mixed and Reg of SAS. Increasing daily intake of CGCM increased (linear; P &lt; 0.05) ADG of pigs. Increasing CGCM supplementation affected (quadratic; P &lt; 0.05) the relative abundance of Lactobacillaceae (minimum: 26.4% at 1.2% CGCM), Helicobacteraceae (maximum: 29.3% at 1.2% CGCM), and Campylobacteraceae (maximum: 9.0% at 1.0% CGCM). Increasing CGCM supplementation affected (quadratic; P &lt; 0.05) the concentrations of immunoglobulin G (maximum: 4.94 µg/mg of protein at 1.0% CGCM) and protein carbonyl (PC; maximum: 6.12 nmol/mg of protein at 1.1% CGCM), whereas linearly decreased (P &lt; 0.05) malondialdehyde (MDA) in the proximal jejunal mucosa. Increasing CGCM supplemention affected (quadratic; P &lt; 0.05) intestinal enterocyte proliferation rate (maximum: 13.3% at 1.0% CGCM), whereas it did not affect intestinal morphology and the nutrient digestibility. In conclusion, supplementing 1.0% to 1.2%, reducing blood plasma supplementation by 0.7% to 0.9%, respectively, increased potential pathogenic microbiota associated in the jejunal mucosa resulting in increased immune response, enterocyte proliferation, and PC concentration. However, supplementing diets with 2.1% CGCM, replacing 1.5% blood plasma, improved growth performance, and reduced MDA without affecting nutrient digestibility, intestinal morphology, and microbiota in the jejunal mucosa. In this study, based on the polynomial contrast, supplementing 1.0% to 1.2% CGCM suppressed the benefits from blood plasma, whereas supplementing 2.1% CGCM showed functional benefits of CGCM with similar effects from blood plasma supplementation.
Periprosthetic fragility fracture of the femur after primary cementless total hip arthroplasty
Authors: Hirao Masanobu , Miyatake Kazumasa , Takada Ryohei , Tachibana Tetsuya , Okawa Atsushi , Jinno Tetsuya 
Published: December 2021

ABSTRACT

Objectives
Periprosthetic bone fragility due to stress shielding (SS) can be a risk factor of periprosthetic fracture after cementless total hip arthroplasty (THA). We aimed to obtain epidemiological information on periprosthetic fragility fracture of the femur (PPFF) after THA.

Methods
We retrospectively reviewed the medical records of 1062 hips that had undergone cementless THA. We evaluated the epidemiological data as well as the features of PPFFs.

Results
Of the 1062 hips, 8 (0.8%) were diagnosed with PPFFs. The survival rates, with the occurrence of PPFF as the end point, were 99.2% and 97.6% at 10 and 16 years postoperatively, respectively. When patients were classified as having either mild or severe SS on radiographs 5 years postoperatively, there was no significant difference in the survival rate, with PPFF as the end point.

Conclusions
In our cases, the incidence of PPFF after cementless THA was 0.8%.
Global research trends in hyperuricemia: a bibliometric and visualized study
Authors: Zhang Qingxi , Li Hui , Xing Dan , Lin Jianhao 
Published: December 2021

ABSTRACT

Objectives
The global trend of research on hyperuricaemia (HUA) has not been well studied. Therefore, this study aimed to investigate the trend of research on HUA and compare the findings in publications from different countries, institutions, journals, and authors, to predict the research hotspots.

Methods
Publications related to HUA were searched using the Science Citation Index-Expanded Web of Science. The data were analysed by using the bibliometric methodology. Additionally, a graphical mapping was generated by using the VOS viewer software to carry out a co-occurrence analysis and to investigate the trend of publications in this field.

Results
A total of 6313 articles were included. The number of publications was increasing globally yearly. USA was the leading country in global research in this field, with the largest number of publications and citations as well as the highest H-index (H-index reflects both the number of publications and the number of citations per publication). PLOS One published the largest number of publications related to HUA. JOHNSON RJ T has published the largest number of papers in this field. Published studies could be classified into six clusters: ‘Pathophysiology’, ‘HUA and metabolic syndrome’, ‘HUA and cardiovascular disease’, ‘HUA and gout’, ‘HUA and nephropathy’, and ‘Genome-wide research’. ‘Pathophysiology’, ‘HUA and cardiovascular disease’, ‘HUA and gout’, and ‘Genome-wide research’ were predicted as the next hot topics in HUA research.

Conclusions
USA was the leading country in global research in this field. It is expected that an increasing research output will continue to be observed in the near future. ‘Pathophysiology’, ‘HUA and cardiovascular disease’, ‘HUA and gout’, and ‘Genome-wide research’ may be the next hotspots and hence need more attention in the future.
Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients
Authors: Roussotte Mickaël , Gerfaud-Valentin Mathieu , Hot Arnaud , Audia Sylvain , Bonnotte Bernard , Thibault Thomas , Lobbes Hervé , Le Guenno Guillaume , Goulabchand Radjiv , Cathebras Pascal , Varron Loig , Dufour Jean François , Deroux Alban , Compain Caroline , Baudet Antoine , Karkowski Ludovic , Pérard Laurent , Ebbo Mikael , Lega Jean-Christophe , Sève Pascal 
Published: December 2021

Abstract

Objectives
To describe the characteristics, treatment and outcome of patients with immune thrombocytopenia with clinical significance (ITPCS) associated with SLE.

Methods
This retrospective multicentre study included SLE patients who experienced ≥1 ITPCS (defined as ITP with attributable bleeding disorders and/or a platelet count &lt;30×109/l). Other causes of secondary thrombocytopenia were excluded. Major bleeding event (MBG) was defined as Khellaf score &gt;8 and/or WHO score &gt;2.

Results
A total of 90 patients were included, the median (range) follow-up duration was 80 (6–446) months. ITP was diagnosed before SLE in 25 patients. They presented a high rate of autoimmune haemolytic anaemia (15%), antiphospholipid antibody (62%) and antiphospholipid syndrome (19%). The 25 (28%) patients who experienced MBG had significantly more bleedings at ITP diagnosis and higher bleeding scores, and serositis and thrombosis during follow-up. They required significantly more treatment lines, transfusions and hospitalizations. The 11 (12%) patients who experienced no bleeding event presented a significantly more restricted SLE phenotype (cutaneous and/or articular). Patients received a mean (range) of 4.2 (1–11) treatment lines. Corticosteroids and HCQ allowed ITPCS overall response in one-third of patients. The median relapse-free survival of rituximab (n = 34), AZA (n = 19), MMF (n = 8), thrombopoietin-receptor agonists (n = 16) and splenectomy (n = 19) were 53, 31.5, 61, 24.5 and 78 months, respectively. Four patients experienced thrombotic events after splenectomy and one occurred under thrombopoietin-receptor agonist treatment.

Conclusion
SLE-ITCS patients displayed a high rate of haematological abnormalities and MBG patients exhibited higher morbidity. Management of thrombocytopenia was highly heterogeneous and many options seem viable.