bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils
Authors: da Silva Lima Danilo , da Silva Gomes Liana , de Sousa Figueredo Esther , e Silva Yasmin Inocêncio Fernandes , Silva Edvaldo Mendes , de Souza Bovi Thais , Taboga Sebastião Roberto , Marques Mara Rúbia , Biancardi Manoel Francisco , dos Santos Fernanda Cristina Alcantara 
Published: November 2021

AbstractAluminum (Al) is a widespread metal in the environment, and is found in fresh or processed foods, household utensils, packaging, and medicines. In addition to its high toxicity, Al can also have estrogenic agonistic effects on target organs. Considering that the Al effects on the prostate are little known, the aim of this study was to evaluate the impact of aluminum chloride (AlCl3) subacute exposure on the morphophysiology of the male ventral prostate and the female prostate of adult gerbils. Furthermore, the glandular restoration capacity in face of the Al insults was evaluated in gerbils that were submitted to 30 days of recovery. Male and female gerbils were orally exposed to AlCl3 (10 mg/kg) for 30 consecutive days. The animals were euthanized 1 day (Al1D) or 30 days (Al30D) after the end of treatment. Prostates were dissected out and processed for structural, ultrastructural and immunohistochemical analyses. Male ventral prostates and female prostates of the Al1D group showed increased cell proliferation, glandular hyperplasia, increased secretory activity and greater androgen receptor immunoreactivity. In males, Al withdrawal (Al30D) allowed a partial recovery of the prostate, as the glandular secretory activity, and frequency of androgen receptor positive cells were similar to the control group. In females, the recuperation interval (Al30D) was not enough to restore the prostatic morphology, since the gland remained hyperplastic, proliferative, and with greater androgen and estrogen receptor immunoreactivity. These data alert to the importance of avoiding Al exposure, since this metal can have a harmful and prolonged action on the prostate.
The environmental flows implementation challenge: Insights and recommendations across water‐limited systems
Authors: Wineland Sean M. , Bașağaoğlu Hakan , Fleming Jeri , Friedman Jack , Garza‐Diaz Laura , Kellogg Wayne , Koch Jennifer , Lane Belize A. , Mirchi Ali , Nava Luzma F. , Neeson Thomas M. , Ortiz‐Partida J. Pablo , Paladino Stephanie , Plassin Sophie , Gomez‐Quiroga Grace , Saiz‐Rodriguez Ramon , Sandoval‐Solis Samuel , Wagner Kevin , Weber Newakis , Winterle James , Wootten Adrienne M. 
Published: November 2021

AbstractEnvironmental flows (e‐flows) are powerful tools for sustaining freshwater biodiversity and ecosystem services, but their widespread implementation faces numerous social, political, and economic barriers. These barriers are amplified in water‐limited systems where strong trade‐offs exist between human water needs and freshwater ecosystem protection. We synthesize the complex, multidisciplinary challenges that exist in these systems to help identify targeted solutions to accelerate the adoption and implementation of environmental flows initiatives. We present case studies from three water‐limited systems in North America and synthesize the major barriers to implementing environmental flows. We identify four common barriers: (a) lack of authority to implement e‐flows in water governance structures, (b) fragmented water governance in transboundary water systems, (c) declining water availability and increasing variability under climate change, and (d) lack of consideration of non‐biophysical factors. We then formulate actionable recommendations for decision makers facing these barriers when working towards implementing environmental flows: (a) modify or establish a water governance framework to recognize or allow e‐flows, (b) strive for collaboration across political jurisdictions and social, economic, and environmental sectors, and (c) manage adaptively for climate change in e‐flows planning and recommendations.This article is categorized under:Water and Life > Conservation, Management, and AwarenessHuman Water > Water GovernanceEngineering Water > Planning Water
Drazin-Star and Star-Drazin Inverses of Bounded Finite Potent Operators on Hilbert Spaces
Authors: Pablos Romo Fernando 
Published: November 2021

AbstractThe aim of this work is to extend to bounded finite potent endomorphisms on arbitrary Hilbert spaces the notions of the Drazin-Star and the Star-Drazin of matrices that have been recently introduced by D. Mosić. The existence, structure and main properties of these operators are given. In particular, we obtain new properties of the Drazin-Star and the Star-Drazin of a finite complex matrix. Moreover, the explicit solutions of some infinite linear systems on Hilbert spaces from the Drazin-Star inverse of a bounded finite potent endomorphism are studied.
Early molecular imaging response assessment based on determination of total viable tumor burden in [68Ga]Ga-PSMA-11 PET/CT independently predicts overall survival in [177Lu]Lu-PSMA-617 radioligand therapy
Authors: Rosar Florian , Wenner Felix , Khreish Fadi , Dewes Sebastian , Wagenpfeil Gudrun , Hoffmann Manuela A. , Schreckenberger Mathias , Bartholomä Mark , Ezziddin Samer 
Published: November 2021

Abstract

Purpose
In patients with metastatic castration-resistant prostate cancer (mCRPC) treated with prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT), the predictive value of PSMA PET/CT-derived response is still under investigation. Early molecular imaging response based on total viable tumor burden and its association with overall survival (OS) was explored in this study.

Methods
Sixty-six mCRPC patients who received [177Lu]Lu-PSMA-617 RLT within a prospective patient registry (REALITY Study, NCT04833517) were analyzed. Patients received a [68Ga]Ga-PSMA-11 PET/CT scan before the first and after the second cycle of PSMA-RLT. Total lesion PSMA (TLP) was determined by semiautomatic whole-body tumor segmentation. Molecular imaging response was assessed by change in TLP and modified PERCIST criteria. Biochemical response was assessed using standard serum PSA and PCWG3 criteria. Both response assessment methods and additional baseline parameters were analyzed regarding their association with OS by univariate and multivariable analysis.

Results
By molecular imaging, 40/66 (60.6%) patients showed partial remission (PR), 19/66 (28.7%) stable disease (SD), and 7/66 (10.6%) progressive disease (PD). Biochemical response assessment revealed PR in 34/66 (51.5%) patients, SD in 20/66 (30.3%), and PD in 12/66 (18.2%). Response assessments were concordant in 49/66 (74.3%) cases. On univariate analysis, both molecular and biochemical response (p = 0.001 and 0.008, respectively) as well as two baseline characteristics (ALP and ECOG) were each significantly associated with OS. The median OS of patients showing molecular PR was 24.6 versus 10.7 months in the remaining patients (with SD or PD). On multivariable analysis molecular imaging response remained an independent predictor of OS (p = 0.002), eliminating biochemical response as insignificant (p = 0.515).

Conclusion
The new whole-body molecular imaging–derived biomarker, early change of total lesion PSMA (TLP), independently predicts overall survival in [177Lu]Lu-PSMA-617 RLT in mCRPC, outperforming conventional PSA-based response assessment. TLP might be considered a more distinguished and advanced biomarker for monitoring PSMA-RLT over commonly used serum PSA.
Breeding den selection by Arctic foxes (Vulpes lagopus) in southern Yamal Peninsula, Russia
Authors: Hofhuis Stijn P. , Ehrich Dorothee , Sokolova Natalia A. , van Hooft Pim , Sokolov Aleksandr A. 
Published: November 2021

AbstractSelecting the right location for a den during the breeding season is a type of habitat selection in the Arctic fox (Vulpes lagopus) that is likely to affect its reproductive success. A den’s suitability likely depends on its ability to provide shelter, as well as its proximity to prey resources. Depending on the different relative risks that Arctic foxes may face across their broad circumpolar range, Arctic foxes may place different emphases on selection for shelter and prey resources in different ecosystems. Understanding the different requirements for reproduction under different ecological conditions is highly relevant to conservation efforts in areas where Arctic foxes are threatened by rapid environmental changes. Here, we investigated the relative selection for shelter and prey resources in southern Yamal Peninsula (Russia) using data from 45 dens collected over a 13-year period. Arctic foxes preferred to breed in dens with more den entrances; an indicator of shelter quality. Arctic foxes also preferred dens surrounded by more prey resources (quantified by the amount of river valley habitat), but this result was less conclusive. These results complement the findings reported from other study areas, illustrating that Arctic foxes in ecosystems with diverse predator communities may put emphasis on selection for shelter quality. In less productive ecosystems, Arctic foxes may rather put emphasis on selection for prey resources. As tundra ecosystems become more productive and generalist predators move north, the reproductive requirements and habitat selection of Arctic foxes may change accordingly, depending on the species’ ability to adapt.
Adherence to fecal immunochemical test screening among adults at average risk for colorectal cancer
Authors: Fisher Deborah A. , Princic Nicole , Miller-Wilson Lesley-Ann , Wilson Kathleen , DeYoung Kathryn , Ozbay A. Burak , Limburg Paul 
Published: November 2021

Abstract
Purpose
This study examined adherence to screening for fecal immunochemical test (FIT).

Methods
Adults (≥ 50–75) with a FIT between 1/1/2014 and 6/30/2019 in MarketScan administrative claims were selected (index = earliest FIT). Patients were followed for 10 years pre- and 3 years post-index. Patients at increased risk for CRC or with prior screening were excluded. Year over year adherence was measured post-index.

Results
Of 10,253 patients, the proportion adherent to repeat testing at year 2 was 23.4% and 10.6% at year 3. Of 76.6% not adherent in year 2, 5.4% were adherent in year 3.

Conclusion
Results suggest adherence to FIT tests is poor, minimizing potential benefits. Future studies are needed to consider alternative test options and whether more choice will improve long-term adherence.
Crossing the Red Line? Empirical Evidence and Useful Recommendations on Questionable Research Practices among Business Scholars
Authors: Latan Hengky , Chiappetta Jabbour Charbel Jose , Lopes de Sousa Jabbour Ana Beatriz , Ali Murad 
Published: November 2021

AbstractAcademic leaders in management from all over the world—including recent calls by the Academy of Management Shaw (Academy of Management Journal 60(3): 819–822, 2017)—have urged further research into the extent and use of questionable research practices (QRPs). In order to provide empirical evidence on the topic of QRPs, this work presents two linked studies. Study 1 determines the level of use of QRPs based on self-admission rates and estimated prevalence among business scholars in Indonesia. It was determined that if the level of QRP use identified in Study 1 was quite high, Study 2 would be conducted to follow-up on this result, and this was indeed the case. Study 2 examines the factors that encourage and discourage the use of QRPs in the sample analyzed. The main research findings are as follows: (a) in Study 1, we found the self-admission rates and estimated prevalence of business scholars’ involvement in QRPs to be quite high when compared with studies conducted in other countries and (b) in Study 2, we found pressure for publication from universities, fear of rejection of manuscripts, meeting the expectations of reviewers, and available rewards to be the main reasons for the use of QRPs in Indonesia, whereas (c) formal sanctions and prevention efforts are factors that discourage QRPs. Recommendations for stakeholders (in this case, reviewers, editors, funders, supervisors, chancellors and others) are also provided in order to reduce the use of QRPs.
Is it climate change? Coverage by online news sites of the 2019 European summer heatwaves in France, Germany, the Netherlands, and the UK
Authors: Painter James , Ettinger Joshua , Doutreix Marie-Noëlle , Strauß Nadine , Wonneberger Anke , Walton Peter 
Published: November 2021

AbstractIn 2019, several countries across Western Europe experienced record-breaking temperatures and heatwaves which, in some cases, reached temperatures of over 40 °C for three to four consecutive days during June and July. Extreme event attribution (EEA) studies show that anthropogenic climate change increased the likelihood of these events by at least three to ten times (with different results for different countries), and increased the temperature by 1.2 to 3.0 °C. The heatwaves resulted in more than 2500 deaths. Based on a content analysis of 267 articles taken from 20 of the most visited online news websites in four of the countries most affected by the heatwaves (France, Germany, the Netherlands, and the UK), we find strong variations between countries and media outlets in how much attention journalists pay to links between climate change and the heatwaves (the UK media the most, and politically left-leaning titles more than right-leaning ones); many different types of statements depicting the link but in general, the presence of accurate, science-based descriptions; a strong presence of EEA studies in the coverage; and more quotes from climate scientists than politicians and NGOs, with a minimal presence of climate change skeptics. These results contribute to our understanding of media coverage around extreme weather events in different countries and media outlets, and how such events might serve as opportunities for public engagement with climate change.
Communicating efficacy: How the IPCC, scientists, and other communicators can facilitate adaptive responses to climate change without compromising on policy neutrality
Authors: McLoughlin Niall 
Published: November 2021

AbstractThe Intergovernmental Panel on Climate Change (IPCC) adopts a solution-oriented approach to communicating climate change, but does not advocate any specific mitigation or adaptation options. While this helps to maintain a neutral stance in relation to policy advocacy, this approach may also create reluctance amongst IPCC scientists to communicate affective information about climate change, which could help to facilitate behavioural and societal transitions to manage climate risks. Research from the social sciences demonstrates that communications can influence cognitive, affective, and behavioural engagement with climate change. Specifically, there is ample evidence that people’s sense of ‘efficacy’ — beliefs about personal or collective capacity to respond, and effectiveness of responses — must be appealed to sufficiently alongside communication about the threats posed by climate change, to help facilitate mitigation and adaptation responses. This essay draws on a range of research findings to argue that the IPCC’s scientists and communications personnel can nurture efficacy beliefs about climate change, without compromising on values of policy neutrality, or undermining public trust. Specifically, the essay draws on communications strategies related to vicarious learning, mastery experiences, highlighting success stories, and use of language and imagery, which have been shown to increase efficacy. The essay has implications for how IPCC scientists and the organisation as a whole engages with a range of audiences, and suggestions also have relevance for other communicators of climate change, such as governments, academics, journalists, health professionals, community leaders, and creative practitioners.
Smoking kills you, littering butts damages others too: analysing sustainable consumer behaviour in the era of circular economy
Authors: Rasool Shahid , Cerchione Roberto , Centobelli Piera , Oropallo Eugenio 
Published: November 2021

AbstractAlthough litter prevention has environmental, social and economic benefits, cigarette butts are the most littered item on earth. While there has been vast research into the relationship between different factors affecting consumer behaviour, further research is needed to examine the antecedents of consumer sustainable behaviour. The aim of this study is to test the impact of feared self and landfill awareness on the sustainable behaviour of consumers using a structural equation modelling approach. Primary data of consumers are used to validate the hypothesised model. The findings highlight that feared self has a positive impact on the sustainable behaviour of consumers, while feared-self congruency and landfill awareness do not affect consumer sustainable behaviour. As for the implications, the results can support academics and strategic managers in the design process of sustainable consumer awareness programs to achieve environmental, social and economic benefits in the era of circular economy.
Unbiased Simulation of Rare Events in Continuous Time
Authors: Hodgson James , Johansen Adam M. , Pollock Murray 
Published: November 2021

AbstractFor rare events described in terms of Markov processes, truly unbiased estimation of the rare event probability generally requires the avoidance of numerical approximations of the Markov process. Recent work in the exact and $$\varepsilon$$
ε
-strong simulation of diffusions, which can be used to almost surely constrain sample paths to a given tolerance, suggests one way to do this. We specify how such algorithms can be combined with the classical multilevel splitting method for rare event simulation. This provides unbiased estimations of the probability in question. We discuss the practical feasibility of the algorithm with reference to existing $$\varepsilon$$
ε
-strong methods and provide proof-of-concept numerical examples.
A survey of damage observed in Izmir due to 2020 Samos-Izmir earthquake
Authors: Demirci Hasan Emre , Karaman Mustafa , Bhattacharya Subhamoy 
Published: November 2021

AbstractAn earthquake of magnitude 6.9 hit the city of Izmir (Turkey) on 30 October 2020, resulting in 117 deaths (in Turkey) and considerable economic losses. The earthquake also triggered a tsunami. Following the earthquake, field surveys are being conducted in a Covid-secure way to study and document the damages caused. The earthquake caused significant damages to residential buildings mainly located in the district of Bayrakli and Bornova. However, no damages were observed in railway and roadway bridges or tunnels and that helped the rescue operations. The damages were mainly structural which included the so-called pancake collapse (where the entire building collapsed) and soft storey type collapse (weak storey characterised with weak columns collapsed), and in some cases, only the ground floor completely collapsed. Due to the proximity of the epicentre and the geology of the area, it seemed that the ground motions were amplified. This technical note provides a summary of the seismological and recorded ground characteristics of the earthquake together with the lessons learnt.
The Handmade Effect: A Model of Conscious Shopping in an Industrialised Economy
Authors: Droege Jasmin 
Published: November 2021

AbstractAlthough online marketplaces for handmade products persist, little theoretical research has been undertaken to explain why firms choose a handmade strategy. In this paper, I develop a model that can explain the persistence through a handmade effect on the consumer side. I show that when consumers are willing to pay a sufficiently high handmade premium, the firm chooses production by hand over superior machine production. When the firm is part of a duopoly, the existence of consumers who care about the conditions under which a product is manufactured can explain the firms’ specialisation and, thus, the observed co-existence of handmade and machine-made products in the economy. Such specialisation is efficient, and can be robust to collusion. The presence of shoppers who are uncertain about the appropriate behaviour may enable the monopolist to use a handmade strategy to signal a social norm of conscious consumption.
Deep convolutional tree-inspired network: a decision-tree-structured neural network for hierarchical fault diagnosis of bearings
Authors: Wang Xu , Gu Hongyang , Wang Tianyang , Zhang Wei , Li Aihua , Chu Fulei 
Published: November 2021

AbstractThe fault diagnosis of bearings is crucial in ensuring the reliability of rotating machinery. Deep neural networks have provided unprecedented opportunities to condition monitoring from a new perspective due to the powerful ability in learning fault-related knowledge. However, the inexplicability and low generalization ability of fault diagnosis models still bar them from the application. To address this issue, this paper explores a decision-tree-structured neural network, that is, the deep convolutional tree-inspired network (DCTN), for the hierarchical fault diagnosis of bearings. The proposed model effectively integrates the advantages of convolutional neural network (CNN) and decision tree methods by rebuilding the output decision layer of CNN according to the hierarchical structural characteristics of the decision tree, which is by no means a simple combination of the two models. The proposed DCTN model has unique advantages in 1) the hierarchical structure that can support more accuracy and comprehensive fault diagnosis, 2) the better interpretability of the model output with hierarchical decision making, and 3) more powerful generalization capabilities for the samples across fault severities. The multiclass fault diagnosis case and cross-severity fault diagnosis case are executed on a multicondition aeronautical bearing test rig. Experimental results can fully demonstrate the feasibility and superiority of the proposed method.
Thoughts Unlocked by Technology—a Survey in Germany About Brain-Computer Interfaces
Authors: Schmid J. R. , Friedrich O. , Kessner S. , Jox R. J. 
Published: November 2021

AbstractA brain-computer interface (BCI) is a rapidly evolving neurotechnology connecting the human brain with a computer. In its classic form, brain activity is recorded and used to control external devices like protheses or wheelchairs. Thus, BCI users act with the power of their thoughts. While the initial development has focused on medical uses of BCIs, non-medical applications have recently been gaining more attention, for example in automobiles, airplanes, and the entertainment context. However, the attitudes of the general public towards BCIs have hardly been explored. Among the general population in Germany aged 18–65 years, a representative online survey with 20 items was conducted in summer 2018 (n = 1000) and analysed by descriptive statistics. The survey assessed: affinity for technology; previous knowledge and experience concerning BCIs; the attitude towards ethical, social and legal implications of BCI use and demographic information. Our results indicate that BCIs are a unique and puzzling way of human–machine interaction. The findings reveal a positive view and high level of trust in BCIs on the one hand but on the other hand a wide range of ethical and anthropological concerns. Agency and responsibility were clearly attributed to the BCI user. The participants’ opinions were divided regarding the impact BCIs have on humankind. In summary, a high level of ambivalence regarding BCIs was found. We suggest better information of the public and the promotion of public deliberation about BCIs in order to ensure responsible development and application of this potentially disruptive technology.