bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zanubrutinib Treatment of Central Nervous System Posttransplant Lymphoproliferative Disorder After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report
Authors: Yang Ting-Ting , Chen Wei-Hao , Zhao Yan-Min , Fu Hua-Rui , Huang He , Shi Ji-Min 
Published: April 2021

Posttransplant lymphoproliferative disorder (PTLD) is a rare complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with poor prognosis. We report a patient with PTLD involved central nervous system (CNS) who treated with zanubrutinib, a second-generation Bruton tyrosine kinase (BTK) inhibitor. Our report supports the efficacy of bruton tyrosine kinase inhibitor zanubrutinib in the treatment of CNS-PTLD, which provides a new therapeutic option.
Cardiovascular Risk of Concomitant Use of Atypical Antipsychotics and Stimulants Among Commercially Insured Youth in the United States
Authors: Zhang Chengchen , Spence O'Mareen , Reeves Gloria , DosReis Susan 
Published: April 2021

Objectives: To investigate the risk of cardiovascular events associated with concomitant use of stimulants and atypical antipsychotics (AAPs) among youth and evaluate whether AAP dose and duration of concomitant use modifies the risk.Methods: We used IQVIA PharMetrics® Plus data from 2006 to 2015 to construct a retrospective cohort of commercially-insured youth aged 5–17 years old who initiated a stimulant medication. Time-varying concomitant stimulant/AAP use was defined as current, past and no concomitant use based on person months. The primary time-varying Cox proportional hazard regression analysis evaluated the risk of cardiovascular events comparing current concomitant use with past and no concomitant use, adjusted for baseline cardiovascular risk. A secondary analysis assessed the risk of cardiovascular events comparing AAP daily doses (&lt;1, 1–2, &gt;2 mg) and duration (&lt;3, 3–6, &gt;6 months) of current concomitant use to no concomitant use. Cardiovascular outcomes included severe (i.e., stroke, acute myocardial infarction, ischemic heart disease) and less severe (i.e., angina pectoris, cardiac dysrhythmias, transient cerebral ischemia, hypertensive disease, tachycardia, palpitations, syncope).Results: For this cohort of 61,438 youths, the incidence rate of severe cardiovascular events was 0.18 per 10,000 person-months, and all events occurred in no concomitant use months. The risk of less severe cardiovascular events was significantly higher in current concomitant users compared with no [HR: 2.59 (95%CI: 1.72, 3.90)] and past [HR: 1.89 (95%CI: 1.10, 3.24)] concomitant users. Compared to no concomitant use, the risk of less severe cardiovascular events was significantly higher at all AAP daily doses [HR: &lt;1 mg: 2.82 (95%CI: 1.72, 4.61); 1–2 mg: 2.22 (95%CI: 1.16, 4.25); &gt;2 mg: 2.65 (95%CI: 1.50, 4.71)]. The risk of less severe cardiovascular events significantly elevated for all duration of use and was higher for &lt;3 months of concomitant use [HR: &lt;3 months: 3.45 (95%CI: 2.17, 5.47) relative to 3–6 months: 2.60 (95%CI: 1.29, 5.25) or &gt;6 months: 2.61 (95%CI: 1.59, 4.30)].Conclusions: Severe cardiovascular events are rare. Concomitant stimulant/AAP use elevates the risk of less severe cardiovascular events. Periodic heart rate or blood pressure monitoring for youth on stimulant/AAP treatment may be warranted.
Characterising generalism in clinical practice: a systematic mixed studies review protocol
Authors: Kelly Martina , Cheung Sarah , Keshavjee Mariam , Stevenson Anna , Elliott Josephine , Singh Surinder , Foster Madeleine , Park Sophie 
Published: April 2021

BackgroundGeneralist physician care is associated with improved patient outcomes. Despite initiatives to promote generalism in educational settings, recruitment to generalist disciplines remains less than required to serve societal needs. Increasingly this impacts not just general practice but also generalist specialties such as internal medicine, surgery, and paediatrics. One potential factor for this deficit is a lack of explicit attention to generalism as a praxis, including clarifying key aspects of generalist expertise.AimTo examine empirical clinical literature on generalism, and characterise how generalism is described and delivered by physicians in primary and secondary care.Design & settingA systematic mixed studies review (SMSR) including quantitative, qualitative, mixed-methods studies, and systematic reviews of physician generalist practice.MethodMEDLINE, Psycinfo, SocINDEX, Embase, Ovid HealthSTAR, Scopus, and Web of Science will be searched for English language studies from 1999 to present, using a structured search. Given study heterogeneity, quality appraisal will not be performed. Two reviewers will perform study selection for each study. Data extraction will focus on how generalism is defined and characterised, including the clinical care provided by generalists and patient experiences of generalist care. Quantitative and qualitative data will be summarised in tabular and narrative form. Convergent synthesis design will then be used to synthesise quantitative and qualitative data.ConclusionFindings will characterise generalism and generalist practice from a grassroots clinical perspective. By identifying similarities and differences across generalist disciplines, this work will inform more focused educational initiatives on generalism at undergraduate and postgraduate level, including collaborations between generalist disciplines.
Embedding brief interventions for alcohol in general practice: a study protocol for the REACH Project feasibility trial
Authors: Sturgiss Elizabeth , Gunatillaka Nilakshi , Ball Lauren , Lam Tina , Nielsen Suzanne , O'Donnell Renee , Barton Chris , Skouteris Helen , Tam Chun Wah Michael , Jacka David , Mazza Danielle , Russell Grant 
Published: April 2021

BackgroundAlcohol is a major source of harm in Australia that disproportionately affects low-income communities. Alcohol brief interventions (ABIs) combine an assessment of a person’s alcohol use with advice to reduce health risks. Despite their effectiveness, ABIs are not routinely performed by clinicians. This article presents a protocol for a feasibility trial of pragmatic implementation strategies and a new set of resources to support clinicians to complete ABIs in Australian general practices.AimTo explore the facilitators and barriers to increasing the uptake of ABIs in primary care, including acceptability, reach, adoption, fidelity, and sustainability.Design & settingA mixed-methods evaluation of the uptake of ABIs in general practice clinics serving low-income communities in Melbourne, Australia. The approach is informed by the Consolidated Framework for Implementation Research (CFIR) and Normalisation Process Theory (NPT).MethodThe implementation strategies and resources will be trialled in five general practices over 12 months. The primary outcome will be change in the proportion of adult patients with a complete alcohol history in their electronic medical records. Baseline data collection includes a practice survey to describe practice routines for ABIs and de-identified patient medical record data on completed alcohol histories (repeated at 3, 6, 9, and 12-months post-intervention). Survey and interview data will also be collected from clinicians, patients, and primary health network staff to assess acceptability and feasibility of the intervention.ConclusionThe study will explore how the implementation strategies and resources can improve alcohol screening and management among low-income patients in general practice.
Sistemas de inventario en las instituciones universitarias públicas de la Costa Oriental del Lago
Authors: Daniela Matos  
Published: April 2021

El propósito fundamental de la investigación fue analizar los sistemas de inventario en las instituciones universitarias públicas de la Costa Oriental del Lago. La metodología utilizada fue de tipo descriptiva, con diseño no experimental, de campo y transeccional. La población objeto de estudio estuvo constituida por 12 sujetos que la trabajan en el área de compra de las universidades seleccionadas. La técnica de recolección de datos fue la encuesta, mediante un cuestionario, conformado por 10 ítems, el cual se sometió a un proceso de validación de cinco expertos y la confiabilidad mediante el método del Coeficiente Alfa de Cronbach, arrojando un resultado de 0.83. La técnica de análisis utilizada fue a través de la media aritmética. Se concluye que a veces se utiliza el análisis ABC, cantidad económica de pedido, justo a tiempo y planificación de requerimiento de materiales, como sistemas de inventarios, que permiten garantizar el abastecimiento de materiales.
Riesgos industriales y la ingeniería de riesgos
Authors: Arroyo Santa Cruz José Alfredo 
Published: April 2021

Estimados lectores de la Revista REBI, para su Comité Editorial es un placer hacerle llegar este nuestro cuarto número y volumen 2, en marco de una pandemia que nos ha hecho visualizar al mundo de una manera diferente. El objeto de la revista es ser un medio de difusión de los resultados originales e inéditos de las investigaciones realizadas por profesores, profesionales y estudiantes en las áreas de la ingeniería, tecnología y afines y que proporcionan una eminente contribución al conocimiento científico y tecnológico. Esta difusión cuenta el avance y estado del conocimiento y busca su divulgación y adecuado resguardo. Nuestros lectores y público al que destinamos la revista es principalmente la comunidad científica y académica en Bolivia, América Latina y el mundo.

Los riesgos industriales traen diversos efectos en los seres vivos, proceso y productos, los que nos ha hecho visualizar la ingeniería de manera diferente. En este marco, es emblemático la construcción del famoso Golden Gate Bridge (puente colgante la ciudad de San Francisco, USA), construido durante el período de 1933 a 1937. Es emblemático ya que por primera vez se da prioridad a la seguridad de los operarios, comenzando a utilizar lentes y cascos especiales, debido a los vientos que eran sujetos durante su trabajo. Además, para limitar los riesgos de pérdidas de vidas humanas durante su construcción se instaló una red de seguridad. La misma salvó la vida de 19 hombres que, durante su construcción cayeron al vacío. Hasta febrero de 1937, cuando un andamio cae con diez (10) personas y, cuyo peso, la malla no fue capaz de soportar ocasionando un accidente fatal.

Un riesgo representa un daño potencial, el cual debe ser limitado para minimizar sus posibles efectos. Actualmente, la Ingeniería de Riesgos es una rama especializada que considera el análisis, diseño y desarrollo de programas de control de riesgos de todo tipo, no sólo los debidos a los procesos industriales, siendo una carrera en auge a nivel global. Para esta carrera existen diferentes ramas que van desde el análisis para la prevención, hasta especializados como riesgos y seguros o riesgos, seguridad y ambiente. En el marco de la pandemia del COVID-19, destaca la función de los ingenieros de estas especialidades que deben garantizar la productividad de los procesos y la salud de los trabajadores y consumidores finales. A ellos y al personal médico, enfermeras y trabajadores que, en general, todos los días
Uso de tecnologías de información y comunicación en el proceso de formación de estudiantes de contaduría pública
Authors: Rojas Génesis 
Published: April 2021

La presente investigación tiene como objetivo proponer el uso de las Tecnologías de Información y Comunicación (TIC) como herramientas de enseñanza en el proceso de formación, para complementar el perfil de los estudiantes egresados de Contaduría Pública de la Facultad de Ciencias Económicas y Sociales de la Universidad de Carabobo, Venezuela. Este estudio reúne las características de una investigación con un nivel comprensivo, bajo la modalidad de proyecto factible, sustentado en un estudio descriptivo con un de diseño de campo no experimental Fue posible concluir que en la Facultad de Ciencias Económicas y Sociales existe una necesidad latente de incluir en el pensum, mayor contenido de las tecnologías de información y comunicación para complementar su currículo, ya que en la actualidad, la mayoría de las empresas utilizan estas herramientas para realizar sus operaciones financieras y los estudiantes de Contaduría Pública necesitan estar mejor preparados en esa área y tener mayor competencia en el campo laboral.
ABSTRACT
The purpose of this research is to propose the use of Information and Communication Technologies (ICTs) as teaching tools in the training process, to complement the profile of students graduated from Public Accounting of the Faculty of Economics and Social Sciences from the University of Carabobo, Venezuela. This study combines the characteristics of a research with a comprehensive level, under the modality of a feasible project, based on a descriptive study with a non-experimental field design. It was possible to conclude that in the faculty of economic and social sciences there is a latent need to include in the curriculum, greater content of information and communication technologies to complement their education, since at present most of the companies use these tools to perform their financial operations, and public accounting students need to be better prepared in that area, and have more competence in the labor field.
La Corte Constitucional como garante del Principio de Independencia Judicial en Ecuador
Authors: Zapata-Fajardo María José , Ronquillo-Riera Orlando Iván , Atencio-González Rously Eedyah 
Published: April 2021

El artículo tiene como propósito analizar la actuación Jurisdiccional de la Corte Constitucional dentro de la Sentencia 3-19-CN/20, en la cual dentro de un proceso de consulta de norma efectuado por un órgano jurisdiccional de instancia, realiza una interpretación conforme principalmente, de la figura de error enexcusable. Por todo ello se planteó como objetivo general analizar la actuación Jurisdiccional de la Corte Constitucional dentro de la Sentencia 3-19-CN/20, en la administracion de justicia y vulneración del principio de Independencia Judicial en Ecuador. Bajo el enfoque cualitativo y metodológicamente desde un tipo descriptivo–documental, mediante un diseño bibliográfico, permitió la revisión analítica conformada por: leyes, documentos jurídicos, artículos y trabajos de investigación, escrutándose a través del método analítico – sintético y análisis de contenido jurídico. Se observa que un órgano jurisdiccional es quien debe declarar la existencia de error inexcusable, dolo o negligencia en la tramitación de causas judiciales, lo contrario supondría irrespeto al principio de independencia judicial.
Online Learning Implementation at Public Elementary Schools in Urban Outskirts
Authors: Sakti Bayu Purbha , Ayu Risma Eka 
Published: April 2021

This research is caused by online learning conducted by public elementary school in suburban areas. Online learning is carried out because the “Covid-19” virus outbreak has become a disaster in the world of education. Online learning requires several facilities such as an internet signal and a smartphone. This facility becomes a problem if an area experiences internet problems. This research is a qualitative descriptive study of phenomenology. The subjects in this study were teachers, parents, and fourth grade students. Data collection used is interviews, observation, and documentation. The data analysis used was data reduction, data presentation and conclusion drawing.The results of this study indicate that the implementation of online learning in grade IV public elementary school in suburban areas during the “Covid-19” pandemic was shown based on input, process, and output indicators. This can be seen from the input indicator, namely the application of teacher characteristics, namely motivation, fostering enthusiasm, and mastering technology, communication. The learning facilities used by students include cellphones/smartphones, internet networks, and the cost of buying internet data packages. Process indicators are related to the allocation of teacher time, namely managing time effectively. The application of time allocation for students is to take advantage of time tolerance in completing tasks. The output indicator is related to student learning outcomes. The application of changes in student attitudes is to be more motivating, disciplining, and timely in submitting assignments.
Academic health services and health needs of college students around the era of the Covid-19 pandemic
Authors: Kotsalou Eirini , Sakellari Evanthia , Lagiou Areti , Kotsalou Evaggelia 
Published: April 2021

Objective: The university medical services vary around the world (even within each university), but there are only a few publications on the utilization of these services by the students. The available on-campus services of public health care might include general health care, women’s centers, mental health care, disability services, wellness resource centers, career counseling, and alcohol and other drug education programs.
Evidence Acquisition: This paper reviews the current literature on the overtime and current (due to Covid-19 pandemic) public health needs of college students based on studies that report the commonest specific diagnostic reasons for using the on-campus health care services.
Results: Special reference is done on mental health problems among students generally and the students of health professions fields (a specific category themselves). Besides, other issues of interest are the substance-related problems among students and their perceptions about mental health problems and on- campus help- seeking services.
Conclusions: It is unanimous that we need further educational and promotional campaigns to enhance the students; help-seeking behaviors, reduce stigmatizing behaviors and create more preventive public health services on campus, but also out-campus due to the Covid-19 pandemic.
Examination of Impact of Di(2-ethylhexyl) Phthalate and Dibutyl Phthalate on Rat Internal Organs by Scanning Acoustic Microscopy and Inductively Coupled Plasma Optical Emission Spectroscopy
Authors: Tanoren Bukem , Albeniz Gurcan , Ahbab Mufide Aydogan , Sener Leyla Turker , Albeniz Işıl , Alkan Fatma Ates , Ozsobaci Nural Pastaci , Selcuk Berzem , Unlu Mehmet Burcin 
Published: April 2021

Objective: Phthalates, despite their endocrine disrupting effects, are widely used as plastifiants. Environmental exposure of phthalates was demonstrated to cause fetal death and reproductive toxicity in human beings, as well as in laboratory animals. However, underlying mechanisms are not clear.
Material and Methods: Here, we examine the impact of di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP)on rat lungs, brain and heart by scanning acoustic microscopy (SAM) and inductively coupled plasma optical emission spectroscopy (ICP-OES). First, we evaluate tissues of mother rats and we show that the acoustic impedance values oftissues of DEHP and DBP delivered rats differ from those of tissues of the control rat. Then, element level analyses withinthese tissues are done and element levels within tissues of DEHP and DBP delivered pregnant rats are found to be higherthan those within tissues of the control pregnant rat. We then evaluate the tissues of offspring female rats.
Results: It is shown that acoustic impedance values of tissues of offspring rats of DEHP and DBP delivered mother rats are higher than those of tissues of the control offspring rats of the control mother rat. Besides, element analysis revealshigher element levels in the tissues of offspring rats of DEHP and DBP delivered mother rats.
Conclusion: Therefore, we can conclude that phthalates cause structural and functional changes within rat internal organs such as lungs, brain and heart. In summary, both modalities are confirmatory in a way that tissues of DEHP and DBP exposed pregnant rats and their offspring rats are differentiated by different acoustic impedance values obtained by SAM and higher element levels specified by ICP-OES.
Internationalisation through South-North mobility: Experiences and outcomes of research capacity-building programmes for African scholars in Denmark
Authors: Adriansen Hanne Kirstine , Madsen Lene Møller 
Published: April 2021

Internationalisation of higher education in the global South manifests in different ways through different modalities. Using a multi-disciplinary mobility-lens, this paper discusses outcomes of geographical mobility practiced by African scholars going to universities in the global North as part of research capacity-building programmes. Over the past 30 years, Danida (Danish International Development Assistance) has provided financial assistance – including research visits at Danish universities – to academics in the global South, who would work with problems in their home countries. This type of internationalisation through research capacity building is used in many European countries and is interesting because it facilitates geographical mobility across the North-South socio-economic divide. Based on a survey sent to 499 current and former African scholars as well as 15 qualitative interviews, the aim of this paper is to analyse the reflections from African academics being involved in this type of internationalisation practice. Thereby we give voice to scholars from the global South who are the practitioners of South-North mobility. More specifically, we analyse the role of different locations for becoming an academic and for their knowledge production. Thus, the paper critically examines the impact made by ‘internationalisation as mobility’ on the personal and professional development of African academics.
Key words: Internationalisation, Academic mobility, Knowledge production, Africa, Capacity building
How to cite this article: Adriansen, H.K. & Madsen, L.M. 2021. Internationalisation through South-North mobility: Experiences and outcomes of research capacity-building programmes for African scholars in Denmark. Scholarship of Teaching and Learning in the South. 5(1): 46-65. DOI: 10.36615/sotls.v5i1.166.
This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Pendampingan Membangun Pemimpin Hamba Di Sekolah Tinggi Theologia Ebenhaezer
Authors: Kusradi Sri Wahyuni , Butarbutar Marlon , Pasaribu Ferdinan 
Published: April 2021

This article intends to describe a pattern of mentoring to shape the students of Ebenhaezer Theological Seminary (Ind. STTE) as servant leaders. This is motivated by the lack of the number of servants of God who can become a leader at the same time. There is also the view that a true leader is only born, not formed. There are many discussions about Servant Leader, but this article intends to discuss how to be mentored informing as a servant leader in the STTE. In this article, the author uses qualitative methods. To find this problem, the writer interviewed several students who were being formed in the STTE. The writer also tried to find a theoretical basis for nurturing or mentoring to form Servant Leaders and make them relevant in the formation of Theology students. Based on this evaluation, it can be seen that effective tutoring or mentoring can help students become powerful Servant leaders.