bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Identification of Blood Biomarkers of Chronic Neuropathic Pain by Comparative Transcriptomics
Authors: Islam Barira , Stephenson John , Young Bethan , Manca Maurizio , Buckley David A. , Radford Helen , Zis Panagiotis , Johnson Mark I. , Finn David P. , McHugh Patrick C. 
Published: November 2021

AbstractIn this study, we recruited 50 chronic pain (neuropathic and nociceptive) and 43 pain-free controls to identify specific blood biomarkers of chronic neuropathic pain (CNP). Affymetrix microarray was carried out on a subset of samples selected 10 CNP and 10 pain-free control participants. The most significant genes were cross-validated using the entire dataset by quantitative real-time PCR (qRT-PCR). In comparative analysis of controls and CNP patients, WLS (P = 4.80 × 10–7), CHPT1 (P = 7.74 × 10–7) and CASP5 (P = 2.30 × 10–5) were highly significant, whilst FGFBP2 (P = 0.00162), STAT1 (P = 0.00223), FCRL6 (P = 0.00335), MYC (P = 0.00335), XCL2 (P = 0.0144) and GZMA (P = 0.0168) were significant in all CNP patients. A three-arm comparative analysis was also carried out with control as the reference group and CNP samples differentiated into two groups of high and low S-LANSS score using a cut-off of 12. STAT1, XCL2 and GZMA were not significant but KIR3DL2 (P = 0.00838), SH2D1B (P = 0.00295) and CXCR31 (P = 0.0136) were significant in CNP high S-LANSS group (S-LANSS score > 12), along with WLS (P = 8.40 × 10–5), CHPT1 (P = 7.89 × 10–4), CASP5 (P = 0.00393), FGFBP2 (P = 8.70 × 10–4) and FCRL6 (P = 0.00199), suggesting involvement of immune pathways in CNP mechanisms. None of the genes was significant in CNP samples with low (< 12) S-LANSS score. The area under the receiver operating characteristic (AUROC) analysis showed that combination of MYC, STAT1, TLR4, CASP5 and WLS gene expression could be potentially used as a biomarker signature of CNP (AUROC − 0.852, (0.773, 0.931 95% CI)).
Serum thymus and activation-regulated chemokine (TARC) levels in newly diagnosed patients with Hodgkin lymphoma: a new promising and predictive tool? Preliminary report
Authors: Kopińska Anna , Koclęga Anna , Francuz Tomasz , Helbig Grzegorz 
Published: November 2021

AbstractThymus and activation-regulated chemokine (TARC) is expressed on Reed-Sternberg cells of patients with classical Hodgkin lymphoma (HL) and may serve as a marker in response assessment. In our study, we correlated serum TARC levels with early response to treatment measured by PET/CT in 19 newly diagnosed patients with HL who received ABVD (Adriblastin, Bleomycin, Vinblastine, Dacarbazine) regimen. Finally, 17 patients were analyzed and six of them (35%) achieved PET/CT negativity defined as Deauville (D) 1 or 2 after 2 cycles of ABVD; 11 pts (65%) had D3 on PET/CT. None of the patients presented D 4/5. Median serum TARC levels at diagnosis were significantly higher when compared with healthy controls: 5718 pg/ml vs 76.1 pg/ml (p < 0.001). All study patients were treated with ABVD regimen and there was a significant decrease of baseline serum TARC levels after 2 cycles of therapy. No significant difference of baseline serum TARC levels was demonstrated between patients with D1/2 and D3 whereas levels were significantly decreased after 2 cycles of ABVD in patients D1/2 vs D3; p = 0.049. There was a tendency to higher baseline serum TARC levels in patients with an increased LDH (lactate dehydrogenase) activity (p = 0.08) and in those who progressed when compared with those who maintained response (p = 0.09). Serum TARC levels decrease after chemotherapy and may serve as a marker of response assessment.
Use of meat resources in the Early Pleistocene assemblages from Fuente Nueva 3 (Orce, Granada, Spain)
Authors: Yravedra José , Solano José Antonio , Courtenay Lloyd A. , Saarinen Juha , Linares-Matás Gonzalo , Luzón Carmen , Serrano-Ramos Alexia , Herranz-Rodrigo Darío , Cámara José Miguel , Ruiz Auxiliadora , Titton Stefania , Rodríguez-Alba Juan José , Mielgo Clara , Blain Hugues-Alexandre , Agustí Jordi , Sánchez-Bandera Christian , Montilla Eva , Toro-Moyano Isidro , Fortelius Mikael , Oms Oriol , Barsky Deborah , Jiménez-Arenas Juan Manuel 
Published: November 2021

AbstractOver the last few decades, several types of evidence such as presence of hominin remains, lithic assemblages, and bones with anthropogenic surface modifications have demonstrated that early human communities inhabited the European subcontinent prior to the Jaramillo Subchron (1.07–0.98 Ma). While most studies have focused primarily on early European lithic technologies and raw material management, relatively little is known about food procurement strategies. While there is some evidence showing access to meat and other animal-based food resources, their mode of acquisition and associated butchery processes are still poorly understood. This paper presents a taphonomic and zooarchaeological analysis of the Fuente Nueva-3 (FN3) (Guadix-Baza, Spain) faunal assemblage, providing a more in-depth understanding of early hominin subsistence strategies in Europe. The present results show that hominins had access to the meat and marrow of a wide range of animal taxa, including elephants, hippopotami, and small- and medium-sized animals. At the same time, evidence of carnivore activity at the site suggests that these communities likely faced some degree of competition from large predators when acquiring and processing carcasses.
Application of crude pectolytic enzymes from Saccaharomyces cerevisiae (ATCC 52,712) to starch extraction in Ghana: effects of enzyme technology on pasting characteristics in different cassava varieties
Authors: Agyepong Japheth Kwame , Barimah John 
Published: November 2021

AbstractPrevious work on enzyme application to starch extraction enhanced yield and starch recovery rates as well as modified some physicochemical properties of starches for potential alternative application to industry. The response of the technology, however, showed some sensitivity to variety. The knowledge gap therefore was to establish whether such physicochemical responses (by the technology) to variety affects the pasting parameters of the starches extracted. The pasting parameters of starches extracted from four different cassava varieties (‘Nkabom’, ‘Afisiafi’, ‘Bankyehemaa’ and ‘Esambankye’), with the aid of crude pectolytic enzymes from the Saccharomyces cerevisiae (ATCC 52,712), were investigated. Although a general response pattern was observed for most of the pasting parameters measured, which includes general enhancements (P < 0.05) in starch gelatinization viscosity, with improvements in gelatinization time and temperature and peak viscosities in most of the varieties, there were significant differences (P < 0.05) in their respective peak time and temperature requirements for the attainment of peak viscosity. Values for the breakdown viscosity were also generally increased (P < 0.05). The technology also increased values for setback viscosity in both the ‘Nkabom’ and ‘Bankyehemaa’ varieties but reduced setback values in the ‘Afisiafi’ and ‘Esambankye’ varieties. As pasting properties are one of the most important characteristics of starch that determine its overall utility, knowledge from this study should inform how adoption of the technology would help diversify the various cassava varieties for appropriate domestic and industrial applications while harnessing its benefits of improved starch yield.
Minimizing greenhouse gas emissions of an industrial wastewater treatment plant in terms of water–energy nexus
Authors: Yapıcıoğlu Pelin , Demir Özlem 
Published: November 2021

AbstractIn this paper, (CO2) and methane (CH4) emissions of an industrial wastewater treatment plant were monitored. GHG emissions originated from treatment processes were considered as the direct emissions and determined using closed chamber method. GHG emission due to energy consumption was regarded as the indirect emissions. In the second stage of the study, it was aimed to reduce GHG emissions in terms of water–energy nexus. If the plant is operated under design conditions, energy consumption would be lower according to water–energy nexus. Also, the effect of design conditions on GHG emissions was investigated. Firstly, the correlation was defined between GHG emissions and operational parameters in terms of chemical oxygen demand (COD) and wastewater flow rate using Monte Carlo simulation. Then, design COD and wastewater flow rate were simulated to determine the possible GHG emission for each month. The simulation results show that minimization of GHG emissions might be possible if wastewater plant is operated under design conditions. The minimum greenhouse gas emission in the result of the simulation study is 8.25 kg CO2-eq/d if the plant is operated under design COD and flow rate. Total reduction in GHG emissions is approximately 30% if the plant is operated under design conditions.
Drying of virus-containing particles: modelling effects of droplet origin and composition
Authors: Jarvis Michael C. 
Published: November 2021

Abstract
Background and purpose
Virus-containing aerosol droplets emitted by breathing, speech or coughing dry rapidly to equilibrium with ambient relative humidity (RH), increasing in solute concentration with effects on virus survival and decreasing in diameter with effects on sedimentation and respiratory uptake. The aim of this paper is to model the effect of ionic and macromolecular solutes on droplet drying and solute concentration.

Methods
Deliquescence-efflorescence concepts and Kohler theory were used to simulate the evolution of solute concentrations and water activity in respiratory droplets, starting from efflorescence data on mixed NaCl/KCl aerosols and osmotic pressure data on respiratory macromolecules.

Results
In NaCl/KCl solutions total salt concentrations were shown to reach 10-13 M at the efflorescence RH of 40-55%, depending on the K:Na ratio. Dependence on K:Na ratio implies that the evaporation curves differ between aerosols derived from saliva and from airway surfaces. The direct effect of liquid droplet size through the Kelvin term was shown to be smaller and restricted to the evolution of breath emissions. Modelling the effect of proteins and glycoproteins showed that salts determine drying equilibria down to the efflorescence RH, and macromolecules at lower RH.

Conclusion
Differences in solute composition between airway surfaces and saliva are predicted to lead to different drying behaviour of droplets emitted by breathing, speech and coughing. These differences may influence the inactivation of viruses.
The effect of COVID-19-induced mortality salience on delay discounting: a replication
Authors: Sonmez Fatih 
Published: November 2021

AbstractThis study is a conceptual replication of Kelley & Schmeichel (PLOS ONE 10: e0144228, 2015), which found that thinking about death reduces delay discounting. Unlike the original study, the current study was conducted in an environment where there was a real and tangible mortality threat across the world, that is, COVID-19. Contrary to the findings of the original study, results of the current study revealed that thinking about death increases delay discounting, such that participants who were primed with death thoughts traded “₺200 now” for “₺342.35 three months later,” whereas those in the control condition traded “₺200 now” for “₺319.27 three months later”. The current study also explored the moderating roles of goal orientation and self-esteem in the effect of mortality salience on delay discounting; however, it failed to provide evidence for the moderating roles of these variables.
To compare, or not to compare? Age moderates the relationship between social comparisons on instagram and identity processes during adolescence and emerging adulthood
Authors: Noon Edward John , Schuck Leon Aljosha , Guțu Smaranda Maria , Şahin Burak , Vujović Bojana , Aydın Zeynep 
Published: November 2021

AbstractIntroductionSocial networking sites such as Instagram have provided young people with unprecedented opportunities for social comparison, and such behaviour can have implications for identity development. Although initial evidence suggests that there may be developmental differences in terms of how such behaviour informs identity development during adolescence and emerging adulthood, all previous research has been conducted in highly individualistic cultural contexts (i.e., the UK and the US).MethodTo shed further light on these possible developmental differences and to determine whether results replicate amongst young people from more collectivist cultural contexts, cross‐sectional survey data were collected from 1,085 (M age = 18.87, SD = 2.57; Female = 77.8%) adolescents and emerging adults in Romania and Serbia between December 2019 and March 2020. The relationships between social comparisons of ability and opinion on Instagram and three key identity processes (i.e., commitment, in‐depth exploration, and reconsideration of commitment) were then examined.ResultHierarchical multiple regression analyses identified significant age differences in terms of how social comparisons of ability and opinion on Instagram associated with identity commitment and in‐depth exploration. Furthermore, possible cultural differences were identified in terms of how social comparisons of opinion on Instagram associated with the identity processes.ConclusionOverall, results suggest that whilst social comparisons on Instagram can elicit self‐focus and prompt further exploration, developmental and cultural factors may influence how such behaviour informs identity development during adolescence and emerging adulthood.
Precarious but popular? The German mini-job scheme in comparative research on work and welfare
Authors: Konle-Seidl Regina 
Published: November 2021

AbstractThis review paper critically examines a range of analytical frameworks used to analyse the German mini-job scheme in comparative research on work and welfare. The approaches examined include labour market dualisation in comparative political economy research and welfare-to-work policies in comparative social policy research. The paper claims that using stylized facts instead of a thorough understanding of the broader context of national employment and social systems leads to misinterpretations in terms of policy learning. By describing the institutional context and main drivers of the evolution of mini-jobs over time, based on variety of data sources, statistics and empirical studies, the paper addresses the critical role of this specific employment scheme for gender equality, largely ignored in the comparative literature.
Association between egg consumption and cognitive function among Chinese adults: long-term effect and interaction effect of iron intake
Authors: Sukik Layan , Liu Jianghong , Shi Zumin 
Published: November 2021

AbstractThe association between egg consumption and cognitive function is inclusive. We aimed to assess the association between egg consumption and cognitive function in Chinese adults and tested the interaction between egg consumption and Fe intake. The data used were from a nationwide sample (n 4852, age ≥ 55 years) from the China Health and Nutrition Survey between 1991 and 2006. Assessment of cognitive function was conducted in 1997, 2000, 2004 and 2006. Dietary egg intake was obtained by 24-h dietary recalls of 3 consecutive days during home visits between 1991 and 2006. Multivariable mixed linear regression and logistic regression were used. Egg intake was positively associated with global cognitive function. In fully adjusted models, across the quartiles of egg intake the regression coefficients were 0, 0·11 (95 % CI –0·28, 0·51), 0·79 (95 % CI 0·36, 1·22) and 0·92 (95 % CI 0·43, 1·41), respectively. There was a significant interaction between egg intake and Fe intake. The association between high egg intake and cognitive function was stronger among those with low Fe intake than those with high Fe intake. In addition, there was a significant interaction between egg consumption and sex, with the association mainly observed in women but not men. Furthermore, compared with non-consumers, those with higher egg consumption (Q4) had the OR of 0·93 (95 % CI 0·74, 1·19), 0·84 (95 % CI 0·69, 1·02) for self-reported poor memory and self-reported memory decline, respectively. Higher egg intake is associated with better cognition in Chinese adults among those with low Fe intake.
A political sociology of empire: Mughal historians on the making of Mughal paramountcy
Authors: Sood Gagan D. S. 
Published: November 2021

AbstractIn this article, Mughal understandings of their own past are reconstructed from the standpoint of Mughal paramountcy in around 1700. That was the moment of the empire's greatest territorial reach, when it knew no peer nor threat. To reconstruct contemporary understandings of how this situation came about, histories of the Mughal empire composed by governing officials of the time are analysed using a novel approach rooted in a particular distinction between constants and contingencies. These understandings allow us to recapture the political sociology of empire as apprehended by the Mughal elites. The article's findings are of value for two reasons. Narrowly construed, they help fill a lacuna in mainstream views on Mughal historiography, traditionally dominated by Akbar and his reign, and imbued with the logic of decline (and of its corollary, the transition to colonialism). More broadly, because of the weight accorded to knowledge of the past in the formation of Mughal ruling elites, the findings provide fresh insights into the cognitive framework within which these elites operated at a moment recognized as highly significant then, and in retrospect.
On the smallest singular value of symmetric random matrices
Authors: Jain Vishesh , Sah Ashwin , Sawhney Mehtaab 
Published: November 2021

AbstractWe show that for an
$n\times n$
random symmetric matrix
$A_n$
, whose entries on and above the diagonal are independent copies of a sub-Gaussian random variable
$\xi$
with mean 0 and variance 1,
\begin{equation*}\mathbb{P}[s_n(A_n) \le \epsilon/\sqrt{n}] \le O_{\xi}(\epsilon^{1/8} + \exp(\!-\Omega_{\xi}(n^{1/2}))) \quad \text{for all } \epsilon \ge 0.\end{equation*}
This improves a result of Vershynin, who obtained such a bound with
$n^{1/2}$
replaced by
$n^{c}$
for a small constant c, and
$1/8$
replaced by
$(1/8) - \eta$
(with implicit constants also depending on
$\eta > 0$
). Furthermore, when
$\xi$
is a Rademacher random variable, we prove that
\begin{equation*}\mathbb{P}[s_n(A_n) \le \epsilon/\sqrt{n}] \le O(\epsilon^{1/8} + \exp(\!-\Omega((\!\log{n})^{1/4}n^{1/2}))) \quad \text{for all } \epsilon \ge 0.\end{equation*}
The special case
$\epsilon = 0$
improves a recent result of Campos, Mattos, Morris, and Morrison, which showed that
$\mathbb{P}[s_n(A_n) = 0] \le O(\exp(\!-\Omega(n^{1/2}))).$
Notably, in a departure from the previous two best bounds on the probability of singularity of symmetric matrices, which had relied on somewhat specialized and involved combinatorial techniques, our methods fall squarely within the broad geometric framework pioneered by Rudelson and Vershynin, and suggest the possibility of a principled geometric approach to the study of the singular spectrum of symmetric random matrices. The main innovations in our work are new notions of arithmetic structure – the Median Regularized Least Common Denominator (MRLCD) and the Median Threshold, which are natural refinements of the Regularized Least Common Denominator (RLCD)introduced by Vershynin, and should be more generally useful in contexts where one needs to combine anticoncentration information of different parts of a vector.
Modal Logic S5 Satisfiability in Answer Set Programming
Authors: ALVIANO MARIO , BATSAKIS SOTIRIS , BARYANNIS GEORGE 
Published: November 2021

AbstractModal logic S5 has attracted significant attention and has led to several practical applications, owing to its simplified approach to dealing with nesting modal operators. Efficient implementations for evaluating satisfiability of S5 formulas commonly rely on Skolemisation to convert them into propositional logic formulas, essentially by introducing copies of propositional atoms for each set of interpretations (possible worlds). This approach is simple, but often results into large formulas that are too difficult to process, and therefore more parsimonious constructions are required. In this work, we propose to use Answer Set Programming for implementing such constructions, and in particular for identifying the propositional atoms that are relevant in every world by means of a reachability relation. The proposed encodings are designed to take advantage of other properties such as entailment relations of subformulas rooted by modal operators. An empirical assessment of the proposed encodings shows that the reachability relation is very effective and leads to comparable performance to a state-of-the-art S5 solver based on SAT, while entailment relations are possibly too expensive to reason about and may result in overhead.
Digestibility and nitrogen balance in dairy cows given diets of grass silage and whole crop wheat
Authors: Sutton J D , Abdalla A L , Phipps R H , Cammell S B , Humphries D J 
Published: November 2021

Whole crop wheat (WCW) appears to offer an attractive alternative forage to grass silage for dairy cows, particularly in those areas where maize silage cannot be grown. However in previous feeding trials the inclusion of WCW with grass silage has increased food intake but has not led to a corresponding increase in milk yield (Phipps et al,1993). As part of a programme to try to overcome the low efficiency of diets containing WCW, the present experiment was designed to examine the effects on feed intake and digestibility and milk production of the step-wise replacement of GS by urea-treated WCW.Winter wheat (cv Hussar), harvested at 620g DM/kg fresh weight and preserved with 20 or 40 g urea/kg DM (WCW-2, WCW-4) was compared with first-cut perennial ryegrass silage (GS). Six multiparous Holstein-Friesian cows in mid-lactation were offered six diets over three 4-week periods in an incomplete change-over design. Diets were 6kg DM concentrates daily with forages ad lib. Treatments (DM basis) were GS alone, 2:1 GS:WCW-2 or WCW-4, 1:2 GS: WCW-2 or WCW-4, and WCW-4 alone. Feed intake and milk production were measured in weeks 3 and 4 and digestibility in week 4.
Effect of restricted suckling once daily in Bos taunts x Bos indicus dairy cattle on milk production and reproduction
Authors: Margerison J. K. , Preston T. R. , Phillips C. J. C. 
Published: November 2021

Restricted suckling is one of the most common forms of livestock production in developing countries. It combines partial milk extraction and suckling, in a multi-commodity (milk and calf) production system.The objective of this experiment was to determine the possibility of the use of once daily suckling to increase total milk production without reducing reproductive performance or the ‘ quantity’ of milk extracted at milking in crossbred cattle.A total of 36 cows, locally known as ‘Lucerna’, were placed into two treatments. 18 cows were non-suckled and 18 cows were restricted suckled once daily for 15 minutes following milking (p.m.). All experimental cows had completed two or more lactations and at 3 days post partum were simultaneously allocated to the treatments according to: parity; condition score; previous lactation yield and calving interval. The cows remained in the experiment for 100 days.