bluuebunny/crossref_metadata_2025_split huggingface dataset:
Descriptor and scaling relations for ion mobility in crystalline solids
Authors: Sotoudeh Mohsen , Groß Axel 
Published: June 2021

Abstract
Ion mobility is a critical performance parameter in electrochemical energy storage and conversion, but also in other electrochemical devices. Based on first-principles electronic structure calculations, we have derived a descriptor for the ion mobility in battery electrodes and solid electrolytes. This descriptor is entirely composed of observables that are easily accessible: ionic radii, oxidation states and the Pauling electronegativities of the involved species. Within a particular class of materials, the migration barriers are connected to this descriptor through linear scaling relations upon the variation of either the cation chemistry of the charge carriers or the anion chemistry of the host lattice. The validity of these scaling relations indicates that a purely ionic view falls short of capturing all factors influencing ion mobility in solids.The identification of these scaling relations has the potential to significantly accelerate the discovery of materials with desired mobility properties.
Predictive Evaluation of Quantitative Spatial Profiling of the Tumor Microenvironment by Multiplex Immunofluorescence in Recurrent Glioblastoma Treated with PD-1 Inhibitors
Authors: Cieremans David Alexander , Kim Ju Young , Valencia Ariana , Santos Justin , Bordeaux Jennifer , Tran Thai , Vaupel Christine , Dakappagari Naveen , Tangri Shabnam , Iwamoto Fabio 
Published: June 2021

Abstract
Introduction: PD-1 inhibitors have shown limited efficacy in glioblastoma due to microenvironment immunosuppression and low tumor mutational burden. In GBM, PD-L1 expression is not a predictive marker for response to PD-1 or PD-L1 inhibitors. Multiplex immunostaining panel technology allows for detailed analyses of tumor microenvironment cells and their interaction. Our study to evaluates the feasibility and predictive value of quantitative spatial profiling in GBM.Methods: Pre-treatment tumor tissue was collected retrospectively from 27 patients at Columbia University Irving Medical Center with primary glioblastoma who were diagnosed within the past three years, had surgery here, and were either treated with SOC therapy (n= 8) or PD-1 inhibitors at recurrence (n= 19). Multiplex immunofluorescence panels included 1) CD11b/IDO1/HLADR/GFAP, 2) PD1/PD-L1/GFAP, and 3) CD4/CD8/CD25/FoxP3/Ki67/GFAP. Results: Multiplex immunofluorescence panels did not show any correlation with outcomes in patients treated with SOC therapy. Among the 19 patients treated with PD-1 inhibitors, those with more HLA-DR positive cells had worse outcomes (p= 0.02). PD-L1 expression on tumor cells was not predictive of outcomes. There was a correlation trend between PD-1/PD-L1 interaction score (p= 0.08) and outcomes. PTEN loss was correlated with higher Ki67 expression in both tumor cells (p= 0.05) and non-tumors cells (p= 0.03); however, this was not found in Ki67 in CD4+ cells, CD8+ cells, or CD4+CD8+ cells combined. Tumor-associated macrophages, myeloid-derived suppressor cells, CD8+ cells, and CD4+ cells were not significant predictive markers for outcome. Conclusion: Quantitative spatial profiling by multiplex immunofluorescence is feasible in FFPE glioblastoma tissue. More refined and extensive quantitative and spatial microenvironment analyses may allow for the development of biomarkers for immunotherapy in GBM.
Survival Impact of Number of Removed Para-Aortic Lymph Nodes in Stage I Epithelial Ovarian Cancer
Authors: Günakan Emre , Akıllı Hüseyin , Kara Atacan Timuçin , Altundağ Özden , Haberal Asuman Nihan , Meydanlı Mehmet Mutlu , Ayhan Ali 
Published: June 2021

Abstract
Purpose: The survival effect of presence or absence of lymphadenectomy in early stage epithelial ovarian cancer (EOC) was priorly shown but the effect of number of removed lymph nodes kept in background. We aimed to evaluate the survival impact of number of removed lymph nodes and their localizations in stage I EOC.Methods: Study included 182 patients. Best cut-off levels for number of pelvic and para-aortic lymph nodes(PaLN) were 24 and 10, respectively. Univariate and multivariate survival analyses were performed for these cut-offs and other prognostic factors. Results: Median age of the patients was 49. Median number of removed pelvic and paraartic lymph nodes were 29 and 9, respectively. Median overall(OS) and Progression-free survival(PFS) were 67 and 50 months, respectively. The OS rate was 89.6%. Recurrence occured in 24 (19.5%) patients. In univariate analyses tumor grade(p:0.005), pelvic LN number(p:0.041) and PaLN number(p:0.004) were the factors that were significantly associated with PFS. Tumor grade and PaLN number were independently and significantly associated with PFS in multivariate analyses (p:0.015 and p:0.017, respectively). In OS analyses, age, tumor grade, presence of LVI, number of pelvic and PaLNs were the significantly associated factors (p<0.05 for all). In multivariate analyses age and PaLN number were independently and significantly associated with OS (p:0.011 and p:0.21, respectively). Conclusions: The number and localizations of removed lymph nodes may have a survival affect in stage I EOC. We also think that this study may constitute a kernel point for larger prospective series on lymph node number and lymphatic regions.
Effects of Optimized Water Management on the Uptake and Translocation of Cadmium and Arsenic in Oryza Sativa L. In Two Contaminated Soils
Authors: Bao Qiongli , Bao Wankui , Ding Yongzhen , Huang Yizong 
Published: June 2021

Abstract
Pot experiments were conducted to identify the most efficient water management strategy for reducing Cd and As accumulations and amino acid (AA) synthesis in rice in two soils with different Cd and As contents. A treatment consisting of five days of flooding followed by three days of drainage (F5D3, repeated every eight days) was identified as the most effective treatment for simultaneously decreasing Cd and As in grains, with reductions of grain Cd and As contents of more than 80.0% and 73.1%, respectively, compared with either a drained treatment or a flooded treatment alone; this is probably related to the high efficiency of the F5D3 treatment in reducing dissolved Cd and As according to its minimum “trade-off value”, due to the variations in grain Cd and As contents were significantly correlated with the variations in soil solution Cd (R2 = 0.98) and As (R2 = 0.92, p = 0.0001) concentrations. Additionally, grain Cd content was also significantly related to the organs Cd contents (especially root Cd content, R2 = 0.99) and the root-to-shoot Cd translocation factors (R2 = 0.99), whereas grain As content was significantly related to soil Eh (R2=-0.82, p = 0.003) and pH (R2 = 0.88, p = 0.0008). The AA contents in organs under the F5D3 treatment were lower than those under the Flooded and Drained treatments. These results indicated that the F5D3 treatment was the most effective water management strategy for simultaneously reducing grain Cd and As contents and AA synthesis in rice, which was probably due to there being no need for rice to synthesize abundant AAs to chelate metal ions.
Wideband MR Echo Planar Imaging: A High Temporal/Spatial Resolution Neuro-architecture Study of Rodent Brain
Authors: Cheng Po-Wei , Chiueh Tzi-Dar , Chen Jyh-Horng 
Published: June 2021

Abstract
Latest simultaneous multi-slice (SMS) methods greatly benefit MR efficiency for recent studies using parallel imaging technique. However, these methods are limited by the requirement of array coils. The proposed Coherent Wideband method, which employs an extended field of view to separate multiple excited slices, can be applied to any existing MRI instrument, even those without array coils. In this study, the Coherent Wideband echo-planar imaging method was implemented on 7T animal MRI to exhibit comprehensive enhancements in neuro-architecture, including diffusion tensor imaging (DTI) and functional MR studies (fMRI). Under the same scan time, the time-saving effect can be manipulated to increase the number of averages for DTI SNR improvement, reducing fractional anisotropy difference by 56.9% (from 0.072 to 0.041) and the deviation angle by 64% (from 25.3⁰ to 16.2⁰). In summary, Coherent Wideband EPI will provide faster, higher resolution, thinner slice, or higher SNR imaging for precision neuro-architecture studies.
Post-operative Complications Following Emergency Laparotomy are Common and Associated with Increased Late Mortality – a Retrospective Multi-centre Study.
Authors: sharma shivam , Alderman Joseph , Parekh Dhruv , Thickett David , Patel Jaimin 
Published: June 2021

Abstract
BackgroundThe ﬁrst National Emergency Laparotomy Audit (NELA) highlighted that morbidity and mortality from emergency surgery remains elevated especially in high-risk patients deﬁned as a P-POSSUM mortality ≥ 5% and ASA ≥ 3. The incidence of postoperative pulmonary complications (PPCs) are thought to be high following emergency laparotomy but no recent studies have evaluated the incidence or consequences of PPC following emergency laparotomy in the UK.MethodsA retrospective cohort study was conducted at University Hospital Birmingham and Heartlands Hospital, Birmingham, to investigate the incidence of PPCs following emergency laparotomy. The NELA databases from the two Trusts were used to identify patients. Patients were retrospectively screened for the development of PPCs using the validated Melbourne Group Scale. Data was analysed using Chi-squared test for categorical data and continuous data displayed as medians with statistical analysis from a Mann–Whitney U test. Results A total of 362 correctly coded patients were identified. High-risk patients accounted for 62% (226) of the cohort. These patients were older (p < 0.001) and had higher baseline lactate (p = 0.04) and creatinine levels (p = 0.003). Median P-POSSUM mortality was 10.6% (5.6–31.4%) with 76.4% of patients having an ASA ≥ 3. These patients had an increased length of stay (p < 0.001) and accounted for nearly all the deaths (42 vs. 2; p < 0.001). The incidence of PPCs was 37%, again the incidence was greater in the high-risk group (37% vs. 6% p < 0.001). Development of a PPC was associated with an increased length of stay (17 d vs. 9 d; p < 0.001) as well as a 90, 180 and 360 day mortality.DiscussionThis study demonstrates that the sub-group of patients deemed ‘high-risk’ are at greatest risk of developing a PPC and consequently have an increased length of stay and an increased 90, 180 and 360 day mortality. This allowed us to identify a group of patients at high risk of PPC who we can target with potential novel therapies such as high-ﬂow nasal cannulae oxygen in clinical trials to reduce mortality and morbidity.
An Effective Contour Detection based Image Retrieval using Multi-Fusion Method and Neural Network
Authors: Raja Rohit , Kumar Sandeep , Choudhary Shilpa , Dalmia Hemlata 
Published: June 2021

Abstract

Day by day, rapidly increasing the number of images on digital platforms and digital image databases has increased. Generally, the user requires image retrieval and it is a challenging task to search effectively from the enormous database. Mainly content-based image retrieval (CBIR) algorithm considered the visual image feature such as color, texture, shape, etc. The non-visual features also play a significant role in image retrieval, mainly in the security concern and selection of image features is an essential issue in CBIR. Performance is one of the challenging tasks in image retrieval, according to current CBIR studies. To overcome this gap, the new method used for CBIR using histogram of gradient (HOG), dominant color descriptor (DCD) & hue moment (HM) features. This work uses color features and shapes texture in-depth for CBIR. HOG is used to extract texture features. DCD on RGB and HSV are used to improve efficiency and computation. A neural network (NN) is used to extract the image features, which improves the computation using the Corel dataset. The experimental results evaluated on various standard benchmarks Corel-1k, Corel-5k datasets, and outcomes of the proposed work illustrate that the proposed CBIR is efficient for other state-of-the-art image retrieval methods. Intensive analysis of the proposed work proved that the proposed work has better precision, recall, accuracy
Effects of the Hostile Environment in Postnatal Care (PNC) Practices
Authors: Karim A N M Rezaul 
Published: June 2021

Abstract
Background: Postpartum treatment is an integral part of being a healthy mother and baby. However, neglecting the quality of care during this period can lead to maternal illness or infant death. Complications can be avoided if postpartum care is used properly. The study identified postpartum care practices among mothers of newborns in selected areas of the hilly region of Bangladesh. Method: A cross-sectional study was performed on 556 postpartum mothers. A semi-structured questionnaire was used to gather relevant information through a convenient sampling method for study subject in a hilly region of Bangladesh. Result: A total of 36.2% of mothers received PNC services only. In bivariate analyses, many variables showed strong associations; however, in the multinomial logistic regression study, only a few variables remained significant for post-natal care groups. Mothers with little or little education (1-5 years of schooling) had a significantly lower probability of receiving postnatal care, whereas higher education seems to have a strong and significant connection with the postnatal care practices in the hilly areas of Bangladesh. Women who watched TV had a significantly higher likelihood. Socioeconomic status had a strong relationship with receiving postnatal care services. Cultural beliefs and local perspectives on neonatal care practices predominate there. The study also found that PNC has a significant relationship with ANC. Conclusion: Government and community leaders should work together to strengthen maternal health care and raise health awareness considering their unique way of life and geographical location.
Late Effects in a High-Risk Population of Breast Cancer Survivors
Authors: Sheng Jennifer Y. , Skuli Sarah J. , Thorner Elissa D. , Zafman Nelli , Riley Carol D. , Ruck Jessica M. , Smith Katherine C. , Snyder Claire , Smith Karen L. , Stearns Vered , Wolff Antonio C. 
Published: June 2021

Abstract
Purpose: To better understand the impact of cancer and treatment on outcomes and guide program development, we evaluated breast cancer survivors at risk for long-term medical and psychosocial issues who participated in survivorship care visits (SVs) at Johns Hopkins Hospital.Methods: We conducted a prospective survey study of women with stage I-III breast cancer who participated in SVs from 2010-2016. The same 56-item questionnaire administered at SV and follow-up included an assessment of symptoms, social factors, demographics, anxiety, depression, and comorbidities. We added the Godin Exercise questionnaire to the follow-up. Results: In 2018, 74 participants were identified as disease-free and mailed a follow up survey; 52 (70.3%) completed the survey. At a median follow-up time of 3.1 years after diagnosis, participants were less likely to be employed (54% vs. 67%) than at the SV. About two thirds were sedentary, and this was associated with high body mass index (p=0.02). Sufficiently active participants (≥150 minutes per week of moderate intensity activity) were less likely to report pain (p=0.02) or fatigue (p=0.001). Although 20% had moderate/severe anxiety or depression at follow up, participants who reported employment satisfaction were less likely to be depressed (p=0.02). Conclusions: Awareness of issues faced by survivors is critical for enhancing care and developing models to identify patients who might benefit most from targeted long term interventions.Implications for Cancer Survivors: Interventions to address physical activity, persistent symptoms and mental health are critical for breast cancer survivors.
Simulation Of Underground Liqufied Petroleum Gas (LPG) Storage In A Depleted Field
Authors: Kuiekem Donald , Matateyou Josephine , Boroh William , Ngounouno Ismaila 
Published: June 2021

Abstract
Underground storage in porous media offers enormous prospects as it is possible to rehabilitate abandoned petroleum formation into storage of natural gas, liquefied petroleum gas, carbon dioxide and methane for safety purposes or as strategic reserves. This simulation using CMG software aims to highlight the main mechanisms of gas flow and conservation in an exhausted reservoir and to determine the general conditions for optimal storage by identifying and limiting gas losses.
Moss Biomonitoring of Transboundary Pollutants in Japan’s Mountains
Authors: Oishi Yoshitaka 
Published: June 2021

Abstract
Long-range transported atmospheric pollutants (or transboundary pollutants) include trace metals with isotope ratios and compositions that vary from those of domestic pollutants, which threaten mountain ecosystems. These differences can be applied as indices (trace metal indices) to evaluate the influence of transboundary pollutants on mountain ecosystems. Mosses play important ecological functions in mountains and are sensitive to atmospheric deposition. Therefore, using these indices for moss biomonitoring can provide a more accurate indication of ecosystem health. However, few studies have examined which indices are appropriate for moss biomonitoring. In this study, the effectiveness of moss biomonitoring using trace metal indices was examined for evaluating transboundary pollutants in mountainous areas in Japan. Transboundary pollutants in these areas originate from mainland Asia and are characterized by high lead isotope ratios, lead to zinc (Pb/Zn) ratios, and arsenic to vanadium (As/V) ratios. Given that the abundance of transboundary pollutants decreases with distance from mainland Asia, moss isotope indices are also expected to vary with distance. Based on observations, Pb isotope ratios were found to decrease with distance from mainland Asia; in contrast, Pb/Zn and As/V ratios did not display any notable relationship with distance. These results are likely attributed to biological and environmental factors that affect trace metal contents in moss. Thus, moss Pb isotope ratios are useful indicators of transboundary pollutants in Japan’s mountains, offering an important tool for comparable moss biomonitoring studies in East Asia.
Seasonal effects of Land cover changes on ecological of migratory birds in Al-Hammar Marsh, southern Iraq
Authors: Ali Ali K. Mohammed , Ramahi Fouad K. Al 
Published: June 2021

Abstract
Al-Hammar Marsh in Iraq stands out for hosting the largest concentrations of coastal migratory birds along the migration path between the Arabian Gulf and the Mediterranean Sea. Despite this importance, there is no complete review of the dynamics of these birds. In this study, we collected and analyzed the results of six species of migratory birds (Mallard duck, Graylag goose, White pelican, Barn swallow, Common gull, White stork) in the Region, in addition to the results of the land cover in October of 2000 to 2020, The results show the presence across the past two decades of a change in the population makeup of migratory birds. Complete numbers of migratory birds indicated a decline in the residual types between 2000 and 2020. The disproportion among numbers was also too large for trends to be observed. The region also showed a decrease in the areas of vegetation cover during the study period was equal to 5.0%, 3.5%, and 15.6%, And an increase in the areas of water bodies during the study period was equal to 7.8%, 21.0%, and 62.6%, respectively, Finally, A multivariate analysis suggests a general decline in types that depend on the Wetland for feeding and breeding an in the sublittoral and the offshore zones. Use satellite data can be used for monitoring several variables such as water bodies, vegetation cover, Climate factors that influence the activity of Migratory birds.
Data mining, dashboards and statistics: a powerful framework for the chemical design of molecular nanomagnets
Authors: Duan Yan , Coutinho Joana , Rosaleny Lorena , Cardona Salvador , Baldoví José J. , Gaita-Ariño Alejandro 
Published: June 2021

Abstract
Three decades of intensive research in molecular nanomagnets have brought the magnetic memory in molecules from liquid helium to liquid nitrogen temperature. The enhancement of this operational temperature relies on a wise choice of the magnetic ion and the coordination environment. However, serendipity, oversimplified theories and chemical intuition have played the main role. In order to establish a powerful framework for statistically driven chemical design, we collected chemical and physical data for lanthanide-based nanomagnets to create a catalogue of over 1400 published experiments, developed an interactive dashboard (SIMDAVIS) to visualise the dataset, and applied inferential statistical analysis to it. We found that the effective energy barrier derived from the Arrhenius equation displays an excellent correlation with the magnetic memory, and that among all chemical families studied, only terbium bis-phthalocyaninato sandwiches and dysprosium metallocenes consistently present magnetic memory up to high temperature, but that there are some promising strategies for improvement.
Significance of Tumor Mutation Burden Related Immune Gene in the Progression and Prognosis of Clear Cell Renal Cell Carcinoma
Authors: Yang Zhirong , Yun Duo , Dai Longmei , Wang Qinqin , Guo Xiangli , JinYong Wang , Su Yang , Yun Yaofeng , Che Zhifei 
Published: June 2021

Abstract
Background: Clear cell renal cell carcinoma (ccRCC) is a common renal malignant disease with a poor prognosis. There were limited studies focus on the relationship between Tumor mutation burden (TMB) and ccRCC.Methods: Based on TCGA-ccRCC cohort, we summarized the status of gene mutations in ccRCC. Then, we analyzed the relationship between TMB and clinical characteristic. Meanwhile, we identified some TMB-related immune genes through the intersection of TMB-Related differentially expressed genes (DEGs) and immune related genes. Finally, we selected the highest correction and novel genes for the future analysis.Results: The most common mutation of Variant Classification, Variant Type, SNV Class were missense mutations, SNP, C>T, respectively. Higher TMB related to shorter overall survival (OS), lower age and grade. Finally, we identified PAEP gene, a novel TMB-related immune gene in ccRCC, which was significantly overexpression in ccRCC tissues and cells with progression and poor survival in ccRCC patients. Furthermore, PAEP promoted the invasion, migration, and proliferation of ccRCC cells. Mechanistically, PAEP suppressed the PI3K/Akt/NF-κB signaling pathway.Conclusion: Our study suggests that PAEP might represents a potential target of antibody immunotherapy for ccRCC patients.