bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation
Authors: Sun Yuanxiu , Yuan Yu , Wu Wei , Lei Le , Zhang Lingli 
Published: May 2021

AbstractBone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and can differentiate into chondrocytes, osteoblasts, and adipocytes under specific microenvironment or mechanical regulation. The activities of BMSCs are closely related to bone quality. Previous studies have shown that BMSCs and their lineage-differentiated progeny (for example, osteoblasts), and osteocytes are mechanosensitive in bone. Thus, a goal of this review is to discuss how these ubiquious signals arising from mechanical stimulation are perceived by BMSCs and then how the cells respond to them. Studies in recent years reported a significant effect of locomotion on the migration, proliferation and differentiation of BMSCs, thus, contributing to our bone mass. This regulation is realized by the various intersecting signaling pathways including RhoA/Rock, IFG, BMP and Wnt signalling. The mechanoresponse of BMSCs also provides guidance for maintaining bone health by taking appropriate exercises. This review will summarize the regulatory effects of locomotion/mechanical loading on BMSCs activities. Besides, a number of signalling pathways govern MSC fate towards osteogenic or adipocytic differentiation will be discussed. The understanding of mechanoresponse of BMSCs makes the foundation for translational medicine.
The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrative review
Authors: Carrara Marta , Ferrario Manuela , Bollen Pinto Bernardo , Herpain Antoine 
Published: May 2021

AbstractThe autonomic nervous system (ANS) regulates the cardiovascular system. A growing body of experimental and clinical evidence confirms significant dysfunction of this regulation during sepsis and septic shock. Clinical guidelines do not currently include any evaluation of ANS function during the resuscitation phase of septic shock despite the fact that the severity and persistence of ANS dysfunction are correlated with worse clinical outcomes. In the critical care setting, the clinical use of ANS-related hemodynamic indices is currently limited to preliminary investigations trying to predict and anticipate imminent clinical deterioration. In this review, we discuss the evidence supporting the concept that, in septic shock, restoration of ANS-mediated control of the cardiovascular system or alleviation of the clinical consequences induced by its dysfunction (e.g., excessive tachycardia, etc.), may be an important therapeutic goal, in combination with traditional resuscitation targets. Recent studies, which have used standard and advanced monitoring methods and mathematical models to investigate the ANS-mediated mechanisms of physiological regulation, have shown the feasibility and importance of monitoring ANS hemodynamic indices at the bedside, based on the acquisition of simple signals, such as heart rate and arterial blood pressure fluctuations. During the early phase of septic shock, experimental and/or clinical studies have shown the efficacy of negative-chronotropic agents (i.e., beta-blockers or ivabradine) in controlling persistent tachycardia despite adequate resuscitation. Central α-2 agonists have been shown to prevent peripheral adrenergic receptor desensitization by reducing catecholamine exposure. Whether these new therapeutic approaches can safely improve clinical outcomes remains to be confirmed in larger clinical trials. New technological solutions are now available to non-invasively modulate ANS outflow, such as transcutaneous vagal stimulation, with initial pre-clinical studies showing promising results and paving the way for ANS modulation to be considered as a new potential therapeutic target in patients with septic shock.
Boosting CNN-based primary quantization matrix estimation of double JPEG images via a classification-like architecture
Authors: Tondi Benedetta , Costanzo Andrea , Huang Dequ , Li Bin 
Published: May 2021

AbstractEstimating the primary quantization matrix of double JPEG compressed images is a problem of relevant importance in image forensics since it allows to infer important information about the past history of an image. In addition, the inconsistencies of the primary quantization matrices across different image regions can be used to localize splicing in double JPEG tampered images. Traditional model-based approaches work under specific assumptions on the relationship between the first and second compression qualities and on the alignment of the JPEG grid. Recently, a deep learning-based estimator capable to work under a wide variety of conditions has been proposed that outperforms tailored existing methods in most of the cases. The method is based on a convolutional neural network (CNN) that is trained to solve the estimation as a standard regression problem. By exploiting the integer nature of the quantization coefficients, in this paper, we propose a deep learning technique that performs the estimation by resorting to a simil-classification architecture. The CNN is trained with a loss function that takes into account both the accuracy and the mean square error (MSE) of the estimation. Results confirm the superior performance of the proposed technique, compared to the state-of-the art methods based on statistical analysis and, in particular, deep learning regression. Moreover, the capability of the method to work under general operative conditions, regarding the alignment of the second compression grid with the one of first compression and the combinations of the JPEG qualities of former and second compression, is very relevant in practical applications, where these information are unknown a priori.
Mindfulness-based online intervention on mental health and quality of life among COVID-19 patients in China: an intervention design
Authors: Si Ming-Yu , Xiao Wei-Jun , Pan Chen , Wang Hao , Huang Yi-Man , Lian Jun , Mak Winnie W. S. , Leng Zhi-Wei , Su Xiao-You , Tang Qiu-Ping , Jiang Yu , Feng Lu-Zhao , Yang Wei-Zhong , Wang Chen 
Published: May 2021

Abstract
Background
COVID-19 can lead to increased psychological symptoms such as post-traumatic stress disorder (PTSD), depression, and anxiety among patients with COVID-19. Based on the previous mindfulness-based interventions proved to be effective, this protocol reports a design of a randomized controlled trial aiming to explore the efficacy and possible mechanism of a mindful living with challenge (MLWC) intervention developed for COVID-19 survivors in alleviating their psychological problems caused by both the disease and the pandemic.

Methods
In April 2021, more than 1600 eligible participants from Hubei Province of China will be assigned 1:1 to an online MLWC intervention group or a waitlist control group. All participants will be asked to complete online questionnaires at baseline, post-program, and 3-month follow-up. The differences of mental health status (e.g. PTSD) and physical symptoms including fatigue and sleeplessness between the COVID-19 survivors who receiving the online MLWC intervention and the control group will be assessed. In addition, the possible mediators and moderators of the link between the MLWC intervention and target outcomes will be evaluated by related verified scales, such as the Five Facets Mindfulness Questionnaire. Data will be analyzed based on an intention-to-treat approach, and SPSS software will be used to perform statistical analysis.

Discussion
The efficacy and potential mechanism of MLWC intervention in improving the quality of life and psychological status of COVID-19 survivors in China are expected to be reported. Findings from this study will shed light on a novel and feasible model in improving the psychological well-being of people during such public health emergencies.
Trial registration Chinese Clinical Trial Registry (ChiCTR), ChiCTR2000037524; Registered on August 29, 2020, http://www.chictr.org.cn/showproj.aspx?proj=60034.
Functions of RNA N6-methyladenosine modification in acute myeloid leukemia
Authors: Zheng Xue , Gong Yuping 
Published: May 2021

AbstractAcute myeloid leukemia (AML) is a hematologic malignancy with an unfavorable prognosis. A better understanding of AML pathogenesis and chemotherapy resistance at the molecular level is essential for the development of new therapeutic strategies. Apart from DNA methylation and histone modification, RNA epigenetic modification, another layer of epigenetic modification, also plays a critical role in gene expression regulation. Among the more than 150 kinds of RNA epigenetic modifications, N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes and is involved in various biological processes, such as circadian rhythms, adipogenesis, T cell homeostasis, spermatogenesis, and the heat shock response. As a reversible and dynamic modification, m6A is deposited on specific target RNA molecules by methyltransferases and is removed by demethylases. Moreover, m6A binding proteins recognize m6A modifications, influencing RNA splicing, stability, translation, nuclear export, and localization at the posttranscriptional level. Emerging evidence suggests that dysregulation of m6A modification is involved in tumorigenesis, including that of AML. In this review, we summarize the most recent advances regarding the biological functions and molecular mechanisms of m6A RNA methylation in normal hematopoiesis, leukemia cell proliferation, apoptosis, differentiation, therapeutic resistance, and leukemia stem cell/leukemia initiating cell (LSC/LIC) self-renewal. In addition, we discuss how m6A regulators are closely correlated with the clinical features of AML patients and may serve as new biomarkers and therapeutic targets for AML.
Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures
Authors: Bradshaw Donald V. , Knutsen Andrew K. , Korotcov Alexandru , Sullivan Genevieve M. , Radomski Kryslaine L. , Dardzinski Bernard J. , Zi Xiaomei , McDaniel Dennis P. , Armstrong Regina C. 
Published: May 2021

AbstractTraumatic brain injury (TBI) causes chronic symptoms and increased risk of neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are critical components of neural circuits and particularly vulnerable to TBI. Treatments are needed to protect axons from traumatic injury and mitigate post-traumatic neurodegeneration. SARM1 protein is a central driver of axon degeneration through a conserved molecular pathway. Sarm1−/− mice with knockout (KO) of the Sarm1 gene enable genetic proof-of-concept testing of the SARM1 pathway as a therapeutic target. We evaluated Sarm1 deletion effects after TBI using a concussive model that causes traumatic axonal injury and progresses to CC atrophy at 10 weeks, indicating post-traumatic neurodegeneration. Sarm1 wild-type (WT) mice developed significant CC atrophy that was reduced in Sarm1 KO mice. Ultrastructural classification of pathology of individual axons, using electron microscopy, demonstrated that Sarm1 KO preserved more intact axons and reduced damaged or demyelinated axons. Longitudinal MRI studies in live mice identified significantly reduced CC volume after TBI in Sarm1 WT mice that was attenuated in Sarm1 KO mice. MR diffusion tensor imaging detected reduced fractional anisotropy in both genotypes while axial diffusivity remained higher in Sarm1 KO mice. Immunohistochemistry revealed significant attenuation of CC atrophy, myelin loss, and neuroinflammation in Sarm1 KO mice after TBI. Functionally, Sarm1 KO mice exhibited beneficial effects in motor learning and sleep behavior. Based on these findings, Sarm1 inactivation can protect axons and white matter tracts to improve translational outcomes associated with CC atrophy and post-traumatic neurodegeneration.
Body connection mediates the relationship between traumatic childhood experiences and impaired emotion regulation in borderline personality disorder
Authors: Schmitz Marius , Bertsch Katja , Löffler Annette , Steinmann Sylvia , Herpertz Sabine C. , Bekrater-Bodmann Robin 
Published: May 2021

Abstract
Background
Previous studies revealed an association between traumatic childhood experiences and emotional dysregulation in patients with borderline personality disorder (BPD). However, possible mediating pathways are still not fully understood. The aim of the present study was to investigate the potential mediating role of body connection, describing the awareness of the relationship of bodily and mental states, for the association between a history of traumatic childhood experiences and BPD core symptomatology.

Methods
One-hundred-twelve adult female individuals with BPD and 96 healthy female controls (HC) were included. Impaired emotion regulation, traumatic childhood experiences, and BPD symptomatology were assessed with self-report questionnaires. The Scale of Body Connection was used to assess two dimensions of body connection, that is body awareness, describing attendance to bodily information in daily life and noticing bodily responses to emotions and/or environment and body dissociation, describing a sense of separation from one’s own body, due to avoidance or emotional disconnection. Mann-Whitney U tests were employed to test for group differences (BPD vs. HC) on the two SBC subscales and associations with clinical symptoms were analyzed with Spearman correlations. We performed mediation analyses in the BPD group to test the assumption that body connection could act as a mediator between a history of traumatic childhood experiences and emotion dysregulation.

Results
Individuals with BPD reported significantly lower levels of body awareness and significantly higher levels of body dissociation compared to HC. Body dissociation, traumatic childhood experiences, and emotion dysregulation were significantly positively associated. Further analyses revealed that body dissociation, but not body awareness, significantly and fully mediated the positive relationship between traumatic childhood experiences and impaired emotion regulation in the BPD sample. This mediation survived when trait dissociation, i.e., general dissociative experiences not necessarily related to the body, was statistically controlled for.

Conclusion
Certain dimensions of body connection seem to be disturbed in BPD patients, with body dissociation being an important feature linking a history of traumatic childhood experiences to current deficits in emotion regulation.
Plant–rodent interactions after a heavy snowfall decrease plant regeneration and soil carbon emission in an old-growth forest
Authors: Zhou Qingqiu , Li Debao , Xia Shangwen , Chen Zhe , Wang Bo , Wu Jianping 
Published: May 2021

Abstract
Background
Climate extremes are likely to become more common in the future and are expected to change ecosystem processes and functions. As important consumers of seeds in forests, rodents are likely to affect forest regeneration following an extreme weather event. In April 2015, we began a field experiment after an extreme snowfall event in January 2015 in a primary forest that was > 300 years old. The heavy snow broke many tree limbs, which presumably reduced the numbers of seeds produced. Two treatments (rodent exclusion and rodent access) were established in the forest, in which rodent exclusion were achieved by placing stainlessness nets around the plot borders. Plant abundance, plant species richness, soil properties, soil microbial community composition, basal and substrate-induced respiration were determined in December 2017.

Results
Plant abundance and species richness significantly increased, but soil microbial biomass decreased with rodent exclusion. Urease activity and soil basal respiration also significantly decreased with rodent exclusion. Most other soil properties, however, were unaffected by rodent exclusion. The relative effects of multiple predictors of basal respiration were mainly explained by the composition of the soil microbial community.

Conclusions
After a heavy snowfall in an old-growth forest, exclusion of rodents increased plant regeneration and reduced microbial biomass and soil basal respiration. The main factor associated with the reduction in soil basal respiration was the change in the composition of the soil microbial community. These findings suggest that after a heavy snowfall, rodents may interfere with forest regeneration by directly reducing plant diversity and abundance but may enhance carbon retention by indirectly altering the soil microbial community.
A Markov regenerative process with recurrence time and its application
Authors: Pasricha Puneet , Selvamuthu Dharmaraja 
Published: May 2021

AbstractThis study proposes a non-homogeneous continuous-time Markov regenerative process with recurrence times, in particular, forward and backward recurrence processes. We obtain the transient solution of the process in the form of a generalized Markov renewal equation. A distinguishing feature is that Markov and semi-Markov processes result as special cases of the proposed model. To model the credit rating dynamics to demonstrate its applicability, we apply the proposed stochastic process to Standard and Poor’s rating agency’s data. Further, statistical tests confirm that the proposed model captures the rating dynamics better than the existing models, and the inclusion of recurrence times significantly impacts the transition probabilities.
EU migrant retention and the temporalities of migrant staying: a new conceptual framework
Authors: Hof Helena , Pemberton Simon , Pietka-Nykaza Emilia 
Published: May 2021

AbstractChallenges of weak economic growth, population decline, and labour shortages led many countries across the world to introduce immigration policy changes in order to attract foreign migrants. This paper focuses on Japan (Tokyo) and the UK (Birmingham, Edinburgh and Glasgow) given common concerns over long term demographic trends and the burgeoning lack of labour supply in particular sectors of the economy through use of foreign labour. The paper shifts the focus from efforts focused on attracting and selecting foreign labour to the retention of such individuals. Drawing on research with EU migrants in Japan and the UK, the paper highlights how staying may occur after a period of mobility, rather than only being of relevance to those who never left their home region. The paper develops a new conceptual framework, which helps to identify different dimensions that shape migrant staying as a temporal process. It is highlighted how staying is shaped incrementally and facilitated or undermined over time in relation to the reciprocal importance of diverse assets, anchors and the changing biographies of migrants and the places in which they live – as well as the relational aspects of migrants’ ‘linked lives’.
Morphological alternation and influence of aqueous flare in idiopathic epiretinal membrane
Authors: Ikegami Yasuko , Numaga Jiro , Ue Saori , Sano Tomohiro 
Published: May 2021

Abstract
Background
Idiopathic epiretinal membrane (iERM) is a common retinal disease in the elderly population. The exact pathogenesis of iERM is unknown. The present study aimed to evaluate the relationship between aqueous flare and morphology of iERM using swept-source optical coherence tomography (OCT).

Methods
A consecutive series of 36 eyes of 33 patients with iERM and 109 control eyes of 109 patients were retrospectively examined. Aqueous flare measurements and OCT images were obtained on the same day. The average total retinal, inner retinal, outer retinal, and choroidal thicknesses were calculated using the thickness map mode with an Early Treatment Diabetic Retinopathy Study nine-zone grid that was divided into three zones. The maximum depth of the retinal folds in iERMs was manually measured. The correlation among flare value, maximum depth of folds, and retinal and choroidal thicknesses was evaluated. The morphological changes between the control eyes and the eyes with iERM in different stages were examined.

Results
The result demonstrated a significant positive correlation between the aqueous flare value and total and inner retinal thicknesses in the early stage of iERM. There was a significant positive correlation between the maximum depth of folds and total and inner retinal thicknesses in the early stage of iERM, and the maximum depth of folds significantly increased in the advanced stage. The total and inner retinal thicknesses and proportion of inner retinal thickness significantly increased as the stage of iERM progressed.

Conclusions
The aqueous flare value was associated with retinal thickness in the early stage of iERM, which supports the idea that inflammation or breakdown of blood–ocular barrier is involved in the process of iERM formation. The maximum retinal folds increased as the stage of iERM progressed and retinal thickness increased, which indicates that the tangential force increases as the iERM stage progresses.
Frictions of implementing EU humanitarian aid in Greece (2016–2019)—the Emergency Support Instrument and its practical ramifications
Authors: Dittmer Cordula , Lorenz Daniel F. 
Published: May 2021

AbstractWith the closure of the border with then-Macedonia in early 2016, it was foreseeable that Greece would become the “last station” for a large number of refugees. Flanked by the agreement between Turkey and the European Union of March 2016, Greece underwent a profound transformation from a transit country to a recipient country. Through a new regulation, the Emergency Support Instrument, initially activated by the European Commission 2016–2019, international humanitarian aid operations were supported for the first time in the EU. The article analyzes the resulting frictions on the basis of empirical field research and a broad literature review. While frictions similar to those in other non-European humanitarian operations exist, specific peculiarities due to the operation taking place in an austerity-ridden member state of the EU must also be noted.