bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is it necessary to link the bilateral cement during the process of Percutaneous kyphoplasty？
Authors: Zhao Yan , Li Dong , Liu Zhaoying , Zhang Xinyue , Shi Hu , Mei Xuesong , Shi Zhibin , Fan Li-Hong , Song Qi-Chun 
Published: May 2021

Abstract
BACKGROUND: To evaluate the clinical and biomechanical results of different types of bone cement distribution post bilateral percutaneous kyphoplasty (PKP) in patients with osteoporotic vertebral compression fractures (OVCF). METHODS: A retrospective study of 227 single-segment OVCF patients from May 2017 to November 2020 were operated with bilateral percutaneous kyphoplasty and injected with the same material and the same volume of bone cement. According to the postoperative imaging data of the patients, the patients were allocated into two groups according to whether the bilateral bone cement in the vertebral body was connected. Further, establishment of a three-dimensional finite element model to evaluate the mechanical property of vertebral bodies after percutaneous kyphoplasty. Loading the model in five motion states (compression, forward bending, backward extension, rotation and lateral bending) for force analysis, and compare the stress difference between the fractured vertebrae and adjacent vertebrae under the two cement distributions. RESULTS: Of the 227 patients, 217 eventually received an average follow-up of 22 months. The restoration rate of vertebral body height, the improvement of kyphotic angle and the degree of postoperative improvement of the visual analog scale for pain (VAS) of the two groups of patients were similar, and there was no significant difference between the groups (P>0.05). There was no significant difference in the rate of bone cement leakage between the two groups (P>0.05). But there was a significant difference in the incidence of recurrent vertebral fractures (new fractures of adjacent vertebral bodies and re-fractures of injured vertebrae) (P< 0.05). There was a significant difference in the von Mises stress between the fractured vertebral body and the cranial adjacent vertebra under the same conditions between the two groups of vertebral body models (P＜0.05). CONCLUSION：Administration of bone cement in the center of vertebrae without distribution to both edges may reduce the risk of re-collapse of the injured vertebrae and fracture of adjacent vertebral body on the cranial side.
Reduced Hepatic Steatosis Is Associated With Higher Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Infection
Authors: Mak Lung-Yi , Hui Rex Wan-Hin , Fung James , Liu Fen , Wong Danny Ka-Ho , Li Bofei , Cheung Ka-Shing , Yuen Man-Fung , Seto Wai-Kay 
Published: May 2021

Abstract
BackgroundConcomitant chronic hepatitis B infection (CHB) and non-alcoholic fatty liver disease (NAFLD) is common, but the implications of NAFLD on clinical outcomes of CHB, including hepatocellular carcinoma (HCC), are not well-investigated. MethodsCHB patients were recruited for transient elastography assessment for liver stiffness (LS), and controlled attenuation parameter (CAP), a non-invasive quantification of hepatic steatosis, and were prospectively followed up for development of HCC. Steatosis and severe steatosis were diagnosed by CAP ≥248 dB/m and ≥280 dB/m respectively, and advanced fibrosis/ cirrhosis was diagnosed by LS ≥9 kPa. The independent effect of hepatic steatosis on HCC was examined via propensity score matching (PSM) of LS and other significant clinical variables.ResultsForty-eight patients developed HCC among 2403 CHB patients (55.6% male, median age 55.6 years, 57.1% antiviral-treated, median ALT 26 U/L) during a median follow-up of 46.4 months. Multivariate Cox regression analysis showed age (HR 1.063), male (HR 2.032), Albumin-Bilirubin score (HR 2.393) and CAP (HR 0.993) were associated with HCC development. The cumulative probability of HCC was 2.88%, 1.56% and 0.71%, respectively for patients with no steatosis, mild-to-moderate steatosis, and severe steatosis, respectively (p=0.01). The risk of HCC increased from 1.56% to 8.89% in patients without severe steatosis if advanced fibrosis/cirrhosis were present (p<0.001). PSM yielded 957 pairs of CHB patients and hepatic steatosis was independently associated with HCC (HR 0.41).ConclusionReduced hepatic steatosis was significantly associated with a higher risk of incident HCC in CHB infection. Routine CAP and LS measurements are important for risk stratification.
Contribution of Nuclear BCL10 Expression to Tumor Progression and Poor Prognosis of Advanced and/or Metastatic Pancreatic Ductal Adenocarcinoma by Activating NF-κB-Related Signaling
Authors: Kuo Sung-Hsin , Yang Shih-Hung , Wei Ming-Feng , Lee Hsiao-Wei , Tien Yu-Wen , Cheng Ann-Lii , Yeh Kun-Huei 
Published: May 2021

Abstract
Background:
We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-κB in breast cancer and lymphoma cell lines. In this study, we assessed whether nuclear BCL10 translocation is clinically significant in advanced and metastatic pancreatic ductal adenocarcinoma (PDAC).
Method and materials:
We analyzed the expression of BCL10-, cell cycle-, and NF-κB- related signaling molecules, and the DNA-binding activity of NF-κB in three PDAC cell lines (mutant K-RAS lines: PANC-1 and AsPC-1; wild-type K-RAS line: BxPC-3) using BCL10 short hairpin RNA (shBCL10). To assess the anti-tumor effect of BCL10 knockdown in PDAC xenograft model, PANC-1 cells treated with or without shBCL10 transfection were inoculated into the flanks of mice. We assessed the expression patterns of BCL10 and NF-κB in tumor cells in 136 patients with recurrent, advanced, and metastatic PDAC using immunohistochemical staining.
Results:
We revealed that shBCL10 transfection caused cytoplasmic translocation of BCL10 from the nuclei, inhibited cell viability, and enhanced the cytotoxicities of gemcitabine and oxaliplatin in three PDAC cell lines. Inhibition of BCL10 differentially blocked cell cycle progression in PDAC cell lines. Arrest at G1 phase was noted in wild-type K-RAS cell lines; and arrest at G2/M phase was noted in mutant K-RAS cell lines. Furthermore, shBCL10 transfection downregulated the expression of Cdc2 (PANC-1), cyclin D1 (BxPC-3), p-IκBα, nuclear expression of BCL10, BCL3, and NF-κB (p65), and attenuated the NF-κB pathway activation and its downstream molecule, c-Myc. In a PANC-1-xenograft mouse model, inhibition of BCL10 expression also attenuated the tumor growth of PDAC. In clinical samples, nuclear BCL10 expression was closely associated with nuclear NF-κB expression (p < 0.001), and patients with nuclear BCL10 expression had the worse median overall survival than those without nuclear BCL10 expression (6.90 months versus 9.53 months, p = 0.019).
Conclusion:
Nuclear BCL10 translocation activates NF-κB signaling and contributes to tumor progression and poor prognosis of advanced/metastatic PDAC.
Psychometric Analysis of the Brazilian-Version Kidscreen-27 Questionnaire
Authors: Silveira Pablo Magno da , Bandeira Alexsandra da Silva , Lopes Marcus Vinicius Veber , Borgatto Adriano Ferreti , Silva Kelly Samara da 
Published: May 2021

Abstract
Background
The objective of this study was to verify the reliability, discriminatory power and construct validity of the Kidscreen-27 questionnaire in Brazilian adolescents.
Methods
Adolescents that participated of the pilot study (210 adolescents; 52.9% boys; 13.7 years old) and of the baseline (816 participants; 52.7% girls; 13.1 years old) of the Movimente Project in 2016/2017 composed the sample of the present study. This project was carried out in six public schools in the city of Florianópolis, Santa Catarina, Brazil. Test-retest reproducibility was assessed by the intraclass correlation coefficient and Gwet coefficient; internal consistency through McDonald's Omega; Hankins' Delta G coefficient verified the scale's discriminatory power and; confirmatory factor analysis to assess construct validity.
Results
Reproducibility values ranged from 0.71 to 0.78 for the dimensions (ICC), and ranged from 0.60 to 0.83 for the items (Gwet). McDonald's Ômega (0.82–0.91) for internal consistency measures. Discriminatory power ranging from 0.94 for the dimension Social Support and Friends to 0.98 for Psychological Well-Being. The factorial loads were > 0.40, except for item 19 (0.36). The fit quality indicators of the model were adequate (X2[df] = 1,022.89 [311], p < 0.001; RMSEA = 0.053 (0.049–0.087); CFI = 0.988; TLI = 0.987), confirming the five-factor structure originally proposed.
Conclusions
The Brazilian-version Kidscreen-27 achieved good levels of reproducibility, internal consistency, discriminatory power and construct validity. Its use is adequate to measure the health-related quality of life of adolescents in the Brazilian context.
Symptom cluster patterns based on text clustering method of COVID-19 and its population characteristics in Sichuan province, China
Authors: Cheng Xiuwei , Wan Hongli , Yuan Heng , Zhou Lijun , Xiao Chongkun , Mao Suling , Li Zhirui , Hu Fengmiao , Yang Chuan , Zhu Wenhui , Zhou Jiushun , Zhang Tao 
Published: May 2021

Abstract
Background: Evidence of the aggregation of COVID-19 symptoms was still limited. Exploration of likely cluster patterns of symptoms may be helpful.Methods: This study enrolled a total of 1067 COVID-19 cases. Symptom cluster patterns were explored by text clustering method. A multinomial logistic regression was applied to revealed its population characteristics. And time intervals between symptoms onset and the first visit was analyzed to take into account the symptoms progression over time. Results: Based on text clustering, the symptoms were summarized into 4 groups. Except for the group without obvious symptoms, the dominate individual symptoms under the other three groups were fever (68.7%), expectoration (59.4%) and fatigue (42.7%), respectively. And the most frequent symptom combinations were fever only (47.8%), expectoration only(19.8%) and fatigue accompanied with fever (4.2%), respectively. People aged 45-64 years were more likely to have symptom group 4 than those aged 65 years or older(OR = 2.66, P = 0.015) and had longer time intervals. Conclusions: The symptoms cluster patterns and common symptom combinations under each pattern may provide information for identification of the infected. Middle-aged population was a group expecting more attention, from the perspective of medical delays.
Determinants of institutional delivery in Kenya. Evidence from population and Demographic health survey,2014
Authors: Andegiorgish Amanuel Kidane , Zhu Zhonghai , Elhoumed Mohamed , Qi Qi , Zeng Lingxia 
Published: May 2021

Abstract
Background: Maternal mortality in Kenya remains high. Analysis of the factors associated with institutional delivery is crucial to inform reproductive health policies and programs in public health. Objective: To identify the factors associated with institutional delivery among women of reproductive age in Kenya.Methods: Data sets for this study were extracted from the 2014 Kenya Demographic health surveys (KDHS, 2014); participants were 20,661 women between the age of 15-49-year. Data sets were analyzed using Chi-square tests, univariate and multivariable binary logistic regression. Factor analysis was used to explore potential subpopulation profiles related to institutional delivery. Results: On national average 62.10% of participant women utilized institutional delivery. Although all sociodemographic variables in this analysis were associated with institutional delivery, multivariable analysis show that women from urban place were 1.37 time (95%CI:1.14-1.65) more likely to delivery in health facility compared to women from rural place. Women with higher education level tended to deliver in health facility compared with no education (Secondary and above: OR:4.03; 95%CI:2.91-5.59; primary level: OR:2.03;95%CI:1.53-2.68). Household wealth status was positively associated, richest 11.12 times (95%CI:7.18-17.22), richer 3.88 times (95% CI:2.96-5.07), middle 2.33 times (95%CI:1.87-2.90), and poorer1.82 times (95% CI:1.40-2.23) more to use institutional delivery than the poorest. The odds of having institutional delivery was 2.58 times (95%CI:2.07-3.23) and 1.44 times (95%CI:1.20-1.71) higher among the first and second to fourth birth orders than five or above respectively. Three common factors with high loading socioeconomic on (Wealth quintile, TV watching, Mother’s education, Radio listening, and Place of residence), family support on (Wanted last child, Mother’s occupation, and Husband education), and women status on (Mother age group, Birth order, and Marital status) were found significantly (p<0.001) associated with institutional delivery. Women with high scores of these factors were tended to received more institutional deliveriesConclusion: Institutional delivery is low in Kenya. Maternal health programs focused on subpopulation profiles should be designed to encourage institutional delivery. Further efforts are needed to improve the accessibility and optimal up-take of institutional delivery.
Overexpression and Prognostic Significance of PTPN2 Maybe A Novel Immunotherapy Target in Renal Clear Cell Carcinoma
Authors: Liu Pei-Pei 
Published: May 2021

Abstract
Immunotherapy has significantly advanced in clear cell renal cell carcinoma (ccRCC). We aimed to find a new immune-related prognostic biomarker and immunotherapeutic target for ccRCC. We analyzed the expression, survival, and related immune gene marker sets data of PTPN2 in patients with ccRCC from TCGA. PTPN2 expression was increased in ccRCC compared to normal tissue. PTPN2 was closely related to T stage (P = 0.008 ), TNM stage (P = 0.017 ) and Grade (P = 0.002 ). Overexpression of PTPN2 predicted a poor survival in ccRCC (P < 0.001). PTPN2 was also related to six types of tumor immune-infiltrating cells, including B cells, CD8 + T cells, CD4 + T cells, Macrophage, Neutrophils, Dendritic cells. PTPN2 was related CTLA-4 (P = 5.645404E-26, r = 0.4339333) and PDCD1 (P = 5.645404E-26, r = 0.4339333). Furthermore, the survival rate in patients with high PTPN2 and CTLA4 was significantly lower than that other three strata (P < 0.0001). GSEA and GO biological analysis was conducted, which was indicated PTPN2 was involved in many immune and inflammatory pathways, including IL-4, IL-12, CD3 T-cell, CD4 T-cell, intestinal inflammation, systemic inflammatory regulation related factors, and so on. Our results implied that PTPN2 was considered as the potential immune therapeutic target and prognostic biomarker in ccRCC.
Bufalin Induced Mitochondrial Dysfunction Promotes Apoptosis of Glioma Cells by Regulating Annexin A2 and DRP1 Proteins
Authors: Li Yao , Zhang Yan , Wang Xufang , Yang Qian , Zhou Xuanxuan , Wu Junsheng , Yang Xu , Zhao Yani , Lin Rui , Xie Yanhua , Yuan Jiani , Zheng Xiaohui , Wang siwang 
Published: May 2021

Abstract
Background: Glioma is a common primary central nervous system tumor, and there is still a lack of effective therapeutic drugs that can effectively improve the survival rate of patients in clinical. Bufalin has a good effect in the treatment of various tumors, but the mechanism of how it promotes the apoptosis of glioma cells is still unclear. The aim of this study was to investigate the drug target of bufalin acting on glioma cells, and to clarify the mechanism of apoptosis. Methods: Cell viability and proliferation were evaluated by cck-8 and colony formation assay. Then, the cell cycle and apoptosis, intracellular ion homeostasis, oxidative stress levels and mitochondrial damage were detected after bufalin treatment. DARTS-PAGE technology combined with LC-MS/MS were employed to explore the drug targets of bufalin on U251 cells. Molecular docking and western blot were used to further identify the potential targets. siRNA of Annexin A2 and a DRP1 protein inhibitor Mdivi-1 were also used to verify the target of bufalin.Results: Bufalin upregulated the expression of cytochrome C, cleaved caspase 3, p-Chk1 and p-p53 proteins to cause U251 cell apoptosis and cycle arrest in S phase. Bufalin can also induce oxidative stress in U251 cells, destroy intracellular ion homeostasis, and cause mitochondrial damage. The expression of mitochondrial separation/fusion-related proteins in U251 cells was abnormal, Annexin A2 and DRP1 protein were translocated from cytoplasm to mitochondria, and MFN2 protein was released from mitochondria into cytoplasm after bufalin treatment, which disrupted the mitochondrial division/fusion balance of U251 cells. Conclusions: Our research indicated that bufalin can cause Annexin A2 and DRP1 oligomerization to be located on the surface of mitochondria, and disrupt the mitochondrial division/fusion balance to induce U251 cell apoptosis.
Research on Destroyed Floor Depth ---The Example of the 51302 Working Face in the Liangzhuang Coal
Authors: yu xiaoge , Liu Yifei , Fan Haibin 
Published: May 2021

Abstract
Based on the analysis on factors affecting floor depth, mining depth, dip angle of coal seam, mining thickness, dip length of working face, damage variable of floor strata and whether there are faults and crushed zones in the working face are defined as main influence factors. The classical Down Three Zone Theory, Down Four Zone Theory based on damage mechanics, formula written in the national standard, BP (Back Propagation) neural network algorithm considering various influencing factors and Numerical Simulation Method were applied for predicting floor depth of the 51302 working face. A double-side seal borehole water injection device was used to determine the actual floor depth of the 51302 working face. By comparing the prediction results with the actual measurement results, the prediction results obtained by considering rock damage are closer to reality.
Identifying Priorities, Directions and a Vision for Indigenous Mental Health Using a Collaborative and Consensus-Based Facilitation Approach
Authors: Montesanti Stephanie , Fitzpatrick Kayla , Fayant Bryan , Pritchard Caillie 
Published: May 2021

Abstract
BackgroundMental health disparities between Indigenous and non-Indigenous people in Canada are related to underlying economic, social and political inequities that are legacies of colonization and the oppression of Indigenous cultures. It also widely acknowledged that mental health services currently available may not be culturally appropriate in supporting the health needs of Indigenous Canadians. A two-day Indigenous mental health forum examined mental health needs and gaps among Indigenous communities across the Regional Municipality of Wood Buffalo (RMWB) on Treaty 8 territory, in northern Alberta, Canada. Specifically, the forum’s aims were to: 1) discuss the challenges and opportunities in addressing mental health among Indigenous youth, adults, and families; 2) network key stakeholders from the RMWB to explore where sectors could overlap and collaborate on improving mental health services for Indigenous populations; and 3) create recommendations to support Indigenous peoples’ mental health and wellness across the life course.MethodsWe applied a modified nominal group consensus method embedded within Indigenous knowledge to determine key priorities and directions for Indigenous-focused mental health and synthesize information from discussions that occurred at the forum. The principles of two-eyed seeing were used with the goal of responding to and resolving conflicts between Indigenous ways of knowing and western scientific inquiry that informs mental health services. ResultsFour key themes for setting priorities and directions for Indigenous mental health emerged from roundtable group discussions. 1) understand the realities of mental health experiences for Indigenous peoples, 2) design a holistic and culturally-rooted mental health system, 3) foster cross-sectoral engagement and collaboration on mental health service delivery, and 4) focus on children and youth. On day two of the forum, a participatory community visioning exercise was facilitated during which participants collectively created a community vision for an Indigenous-led mental health response for the RMWB.ConclusionsForum participants described mental health and well-being around holistic concepts of social and emotional well-being. Addressing Indigenous mental health and wellness involves multi-sectoral action in various settings including community and school through programs, policies and other interventions that promote mental health for all Indigenous peoples, as well as for those at greater risk such as children and youth.
Diversity of Cancer-Related Identities in Long-Term Prostate Cancer Survivors after Radical Prostatectomy
Authors: Jahnen Matthias , Mynzak Eike , Meissner Valentin H. , Schiele Stefan , Schulwitz Helga , Ankerst Donna P. , Gschwend Jürgen E. , Herkommer Kathleen , Dinkel Andreas 
Published: May 2021

Abstract
Background

Individuals affected by cancer need to integrate this experience into their personal biography as their life progress after primary therapy, leading to substantial changes in self-perception. This study identified factors uniquely associated with 5 different cancer-related identities in order to improve the understanding of how self-perception in men affected by prostate cancer is associated with certain clinical and psychosocial characteristics.
Methods

In this cross-sectional study, long-term prostate cancer survivors after radical prostatectomy were asked to choose one of 5 cancer-related identities that described them best. Associations with sociodemographic, clinical, and psychological variables were investigated using multivariable logistic regression.
Results

3347 men (mean age 78.1 years) questioned on average 15.6 years after prostatectomy were included. Most men favored the terms “someone who has had cancer” (43.9%) which was associated with a mild disease course, and “patient” (26.3%) which was associated with ongoing therapy and biochemical disease recurrence. Self-descriptions, such as “cancer survivor” (16.8%), “cancer conqueror” (10.9%) and “victim” (2.1%) were less common. “Cancer survivor” was associated with high perceived disease severity (OR: 1.86 [1.44–2.40]). “Cancer survivor” and “cancer conqueror” were related to high benefit finding (OR: 1.89 [1.48–2.40], OR: 1.46 [1.12–1.89] respectively), and only “cancer conqueror” was associated with high well-being (OR: 1.84 [1.35–2.50]). Identification as “victim” was associated with psychological distress and low well-being (OR: 2.22 [1.15–4.31], OR: 0.38 [0.20–0.72] respectively). (all p < 0.05)
Conclusions

Although long-term survival is common among men affected by PCa, they display a large diversity in cancer-related identities, which are associated with unique clinical and psychological characteristics. These cancer-related identities and their distinctive properties are present and seem to interact with psychological well-being even after a long follow-up.