bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-Fiber-Based 3D Tissue Array for Drug Response Assay
Authors: Kato-Negishi Midori , Sawayama Jun , Kawahara Masahiro , Takeuchi Shoji 
Published: December 2021

Abstract
For the establishment of a reproducible and sensitive assay system for three-dimensional (3D) tissue-based drug screening, it is essential to develop 3D tissue arrays with uniform shapes and high-cell numbers that prevent cell death in the center of the tissue. In recent years, 3D tissue arrays based on spheroids have attracted increased attention. However, they have only been used in specific tissues with hypoxic regions, such as cancer tissues, because nutrient deprivation and hypoxic regions are formed in the core as spheroids grow. Herein we propose a method to array cell-encapsulated tube-like tissue (cell fiber (CF)) with diameters <150 µm to prevent nutrient deprivation and hypoxia using a device that can fix the CFs, section them in uniform sizes and transfer them to a 96-well plate. We fabricated the arrays of CF fragments from cell lines (GT1-7), cancer cells (HeLa), mouse neural stem cells (mNSCs), and differentiated mNSCs, and performed drug response assays. The array of CF fragments assessed drug response differences among different cell types and drug responses specific to 3D tissues. The array of CF fragments may be used as a versatile drug screening system to detect drug sensitivities in various types of tissues.
Design and Analysis of a Graphene Based Slotted Bowtie Optical Plasmonic Nanoantenna
Authors: Biswas Richard Victor , Arifin Farhadur 
Published: December 2021

Abstract
A graphene-based modified bowtie plasmonic nanoantenna resonating in the optical frequency spectrum with the periodic directors created by the slots on top of the radiating structure has been proposed in this paper. In the field of nanophotonics, a few optical nanoantennas have been reported to construct multipath wireless nanolinks. At the telecommunication wavelength of 1550 nm (193.5 THz), the maximum directivity of 9.67 dBi has been reached due to the maximum absorption power of graphene sheet by selecting the chemical potential of 0.5 eV. Since graphene supports surface plasmon polariton waves and acts either as an absorptive or transparent medium for distinct chemical potentials, the proposed graphene-based slotted bowtie optical nanoantenna has been optimized to obtain a dynamically controlled triple-directional radiation beam. With this distinctive nature, a multipath intra or inter on-chip wireless nanolink for secure optical data transfer can be realized by integrating a set of our proposed optical plasmonic nanoantennas.
Shear Behavior of Single Cast-in Anchor Simulating Characteristics of Bridge Bearing Anchor
Authors: Choi Jin-Seok , Chin Won Jong , Yuan Tian-Feng , Yoon Young-Soo 
Published: December 2021

Abstract
A bridge bearing anchor transmits various loads of a superstructure to a substructure. However, most anchors are generally designed without consideration of characteristics such as concrete pedestal, grout bedding, and anchor socket. Therefore, this study investigated the shear behavior of anchors in accordance with the edge distance, embedment depth, compressive strength of concrete, and height of the concrete pedestal in order to simulate the practical characteristics of the bridge bearing anchors. The actual shear capacity of the anchor differs from the shear strength calculated by the ACI 318 Code; especially, the importance of the embedment depth is underestimated in the code. An increase in the height of the concrete pedestal has a negative effect on the shear capacity because of the stress concentration. The grout is fractured prior to the occurrence of local damages in concrete, resulting in a secondary moment. As a result, the effect of the level arm is observed. An equation, which can predict the relative cracking degree of concrete, is proposed by analyzing the displacement of grout and concrete. High strain occurs in the stirrups close to the anchor, and the behavior of the strain is more influenced by the embedment depth than the edge distance. Finally, the design equation of concrete breakout strength is modified to predict the more precise shear resistance of a bridge bearing anchor.
Rapid Evaluations of Innovations: A Scoping Review
Authors: Norman Gill , Mason Thomas , Dumville Jo , Bower Peter , Wilson Paul , Cullum Nicky 
Published: December 2021

Abstract
BackgroundThere is increasing demand for more rapid evaluation of innovation in health and social care, to support timely decision-making about service redesign. These pressures have increased during the COVID-19 pandemic. Making evaluations more rapid raises challenges in terms of ensuring rigour and the effective use of resources, but assessment of rapid evaluation methodologies has been lacking. MethodsWe conducted a scoping review to map the developing field of methods of rapid evaluation of innovation in health and social care, to describe the existing literature, categorise different approaches to rapid evaluation, and identify knowledge gaps. We searched multiple databases and websites of key organisations. We prioritised studies with relevance to the context of the NHS in England. We extracted information to enable us to classify and map existing studies on key characteristics. We undertook a narrative synthesis to identify the evidence and the gaps; focussing on the different approaches to conducting rapid evaluation in primary research. ResultsWe identified 14069 records from our searches of which 352 explored rapid evaluations of innovations, methods for rapid evaluation or rapid evaluation of implementation. Our scoping review identified four main approaches used for rapid evaluation: (1) Use of a methodology designed specifically for rapid evaluation;(2) Increasing rapidity by doing less or using a less time-intensive methodology;(3) Use of alternative technologies and/or data to increase the speed of an existing evaluation method; (4) Adaptation of part of a non-rapid evaluation DiscussionThis scoping review identified a lack of clarity about ‘rapid evaluation’ but identified some useful preliminary categories. There is very little comparative research on the impact of using rapid rather than standard evaluation. There is a need for clarity and consistency in terms of what constitutes rapid evaluation, the development of specific methodologies for making evaluation more rapid, and assessment of the advantages and disadvantages of rapid methodology in terms of rigour, cost and impact.
Layered Feature Representation for Differentiable Architecture Search
Authors: Hao Jie , Zhu William 
Published: December 2021

Abstract
Differentiable architecture search (DARTS) approach has made great progress in reducing the com- putational costs of neural architecture search. DARTS tries to discover an optimal architecture module called cell from a predefined super network. However, the obtained cell is then repeatedly and simply stacked to build a target network, failing to extract layered fea- tures hidden in different network depths. Therefore, this target network cannot meet the requirements of prac- tical applications. To address this problem, we propose an effective approach called Layered Feature Repre- sentation for Differentiable Architecture Search (LFR- DARTS). Specifically, we iteratively search for multiple cells with different architectures from shallow to deep layers of the super network. For each iteration, we optimize the architecture of a cell by gradient descent and prune out weak connections from this cell. After obtain- ing the optimal architecture of this cell, we deepen the super network by increasing the number of this cell, so as to create an adaptive network context to search for a deeper-adaptive cell in the next iteration. Thus, our LFR-DARTS can discover the architecture of each cell at a specific and adaptive network depth, which embeds the ability of layered feature representations into each cell to sufficiently extract layered features in different depths. Extensive experiments show that our algorithm achieves an advanced performance on the datasets of CIFAR10, fashionMNIST and ImageNet while at low search costs.
Effectiveness of Regdanvimab in Patients With Mild-to-moderate COVID-19: A Retrospective Cohort Study
Authors: Choi Seong Jin , Park Sang-Won , Lee Eunyoung 
Published: December 2021

Abstract
BackgroundMonoclonal antibodies are a treatment option for patients with mild-to-moderate coronavirus disease (COVID-19). We investigated the effectiveness of regdanvimab, an anti-SARS-CoV-2 monoclonal antibody approved in South Korea, in the treatment of patients with mild-to-moderate COVID-19. MethodsMedical records of mild-to-moderate COVID-19 patients admitted to a COVID-19 designated hospital were reviewed to assess baseline characteristics (age, gender, BMI, and comorbidities) and clinical outcomes such as supplemental oxygen requirements, mortality, and length of hospitalization.ResultsFour hundred seventy-four COVID-19 patients were included in the study, and 66 of them were administered regdanvimab. The proportion of patients requiring supplemental oxygen was significantly lower in the regdanvimab group than in control group without statistical significance (6.1% vs. 22.8%, P = 0.001). There was no significant difference in mortality (0% vs 1.2%, P > 0.999) and the length of hospitalization (median: 10.5 days vs. 7.5 days, P = 0.067) between both groups. Increasing age, male sex, chest X-ray abnormality, underlying chronic kidney disease and administration of regdanvimab were found to have a significant univariate association with oxygen requirement. The multivariate analysis demonstrated that increasing age (OR: 1.03, 95% CI: 1.01-1.05, P < 0.001) and chest X-ray abnormality (OR: 4.40, 95% CI: 2.49-8.21, P < 0.001) were independently associated with higher requirement of oxygen and administration of regdanvimab was independently associated with lower oxygen supplement (OR: 0.17, 95% CI: 0.05-0.47, P < 0.002). ConclusionsRegdanvimab reduced the need for supplemental oxygen and fatalities in mild-to-moderate COVID-19 patients who matching the indications for administration of regdanvimab.
Variability and time series trend analysis of temperature over 1981-2018 in semi-arid Borana zone, southern Ethiopia
Authors: Worku Mitiku Adisu , Feyisa Gudina Legese , Beketie Kassahun Ture 
Published: December 2021

Abstract
BackgroundUnderstanding the climate variability at local scale could help suggest local adaptation responses to manage climate driven impacts. This paper analyzed the variability and trends of temperature over the period 1981-2018 in semi-arid Borana zone of southern Ethiopia using Mann-Kendall (MK) test and inverse distance weighted (IDW) interpolation technique. Gridded (4 km * 4 km) daily temperature data was used to study variability at temporal and spatial scales. ResultsThe results revealed that monthly temperature shows a warming trend where February was the warmest month for both maximum and minimum temperature. Seasonally, the highest maximum and minimum temperatures were observed during Bega. Minimum temperature shows a warming trend during all seasons unlike maximum temperature. Both minimum and maximum temperature shows not significant warming trend at annual timescale. The later decades (20012018) have shown a warming trend compared to a period ahead especially for minimum temperature. The southwestern and southeastern areas across the zone were warmer than any other areas in the region during the studied period. ConclusionTemperature shows variability at shorter than longer timescales. There is a pronounced warming trend for minimum than maximum temperature. Warming condition advances from the northcentral parts towards the southwestern and southeastern areas. Internal variability was observed at temporal and spatial scales and therefore any adaptation responses to local climate variability should consider the microscale climate.
Effects of Straw Return and Feed Addition on the Environment and Nitrogen use Efficiency in the Rice–Crayfish System
Authors: Yuan Pengli , Ni Mingli , Cao Cougui , Jiang Ligeng , Iqbal Anas , Wang Jinping 
Published: December 2021

Abstract
Purpose Understanding the direction of nitrogen flow in the rice-crayfish system (RC) and optimizing the rate of nitrogen fertilizer application (ORN) are of great significance for sustainable development of RC. Methods To this end, a field experiment involving straw and feed treatment was conducted to delineate the flow of the nitrogen present in the straw (straw-N) and feed (feed-N). Second, under different feed and straw treatments, we carried out a mesocosm experiment with different rates of 15N-labeled nitrogen fertilizer application to explore the optimal rate under the effects of feed-N and straw-N supply.Results The results showed that at 75 kg N ha-1(75N), 14% and 1.86% of feed-N and 4.3% and 8.78% of straw-N is absorbed by crayfish and rice, respectively. The percentage of feed-N and straw-N lost to the environment was the lowest at 75N, i.e., 84.48% and 86.92%, respectively. Using straw return to the field and feeding as the basic management measures for RC, we observed that the rice yield was the highest under 75N, and the highest nitrogen utilization efficiency (NUE) was 25%, and the highest the percentage of soil storing nitrogen by the fertilizer-derived was 34% (lost to the environment, at least 41%).Conclusions ORN could help in the effective utilization of feed-N and straw-N via a compensation effect, promote the absorption and transport of nitrogen, and ultimately lead to an improvement in NUE in RC.
The Relationship Between Shape Perception Accuracy and Drawing Ability.
Authors: Robles Kelly , Bies Alex , Lazarides Stefanos , Sereno Margaret 
Published: December 2021

Abstract
Accurate shape perception is critical for object perception, identification, manipulation, and recreation. Humans are capable of making judgements of both objective (physical) and projective (retinal) shape. Objective judgements benefit from a global approach by incorporating context to overcome the effects of viewing angle on an object’s shape, whereas projective judgements benefit from a local approach to filter out contextual information. Realistic drawing skill requires projective judgements of 3D targets to accurately depict 3D shape on a 2D surface, thus benefiting from a local approach. The current study used a shape perception task that comprehensively tests the effects of context on shape perception, in conjunction with a drawing task and several measures of local processing bias, to show that the perceptual basis of drawing skill in neurotypical adults is not due to a local processing bias but to perceptual flexibility, the ability to process local or global information as needed.
Antlion Algorithm Based on Immune Cloning and Its Truss Optimization
Authors: Li Liyancang , Wu Wuyue Yue 
Published: December 2021

Abstract
Antlion optimization algorithm has good search and development capabilities, but the influence weight of elite ant lions is reduced in the later stage of optimization, which leads to slower algorithm convergence and easy to fall into local optimization. For this purpose, an antlion optimization algorithm based on immune cloning was proposed. In the early stage, the reverse learning strategy was used to initialize the ant population. The Cauchy mutation operator was added to the elite antlion update to improve the later development ability of the algorithm; finally, the antlion was cloned and mutated with the immune clone selection algorithm to change the position and fitness value of the antlion, and further improve the algorithm's global optimization ability and convergence accuracy. 10 test functions and a 0~1 backpack were used to evaluate the optimization ability of the algorithm and applied to the size and layout optimization problems of the truss structure. The optimization effect was found to be good through the force effect diagram. It is verified that ICALO is applied to combinatorial optimization problems with faster convergence speed and higher accuracy. It provides a new method for structural optimization.This article is submitted as original content. The authors declare that they have no competing interests.
College Students’ Interest in Programming
Authors: Senior Isaac Ampofo Atta , Junior Isaac Ampofo Atta 
Published: December 2021

Abstract
In today’s world, tertiary institutions provide Computer Science and Information Technology courses to students for them to have the opportunity to improve the thinking computational skills they will need to function in today's computation-dependent society. Moreover, pupils who think they can finish programming tasks successfully are likely more to become interested. Additionally, effective approaches to impart computer programming frequently rise pupils' interest in programming. As a result, the study sought to examine college students’ interest in programming. The research design for the study was a survey method. The study’s population comprise of Computer Science and Information Technology students at Kwame Nkrumah University of Science and Technology. The sample size was 368 where we used a systematic sampling technique to select participants for the study. The study shows that majority of college students have interest in programming. The results revealed that the total number of males who have interest in programming are greater than females and that the total number of males who study programming far outweigh the total number of females. It is recommended that females should be encouraged to study programming at the various institutions that provide programming courses to students.
The Association Between Ventilatory Ratio and Mortality of Adult Patients with ARDS: Systematic Review and Meta-Analysis
Authors: Jiang Lianlian , Chang Wei , Yuan Xueyan , Sun Qin , Hu Zihan , Xie Jianfeng , Yang Yi 
Published: December 2021

Abstract
Background: Ventilatory ratio is a simple bedside index of impaired efficiency of ventilation and correlates well with physiological dead space fraction in patients with ARDS. So it was regarded as a dead-space marker associated with mortality in mechanically ventilated adults with ARDS. However, the association between VR and outcome of patients with ARDS remains largely unknown. Methods: We searched articles in three electronic databases including PubMed, EMBASE and Web of Science. All the English publications up to 1 st Oct. 2021 will be searched without any restriction of countries. All the observational study that investigated the association between ventilatory ratio and the mortality of ARDS patients were identified in this meta-analysis. The main outcome was mortality. Summary estimates of effect using odds ratio (OR) for dichotomous outcomes with accompanying 95% confidence interval (CI) were expressed. Results: A total of 9 trials enrolling 5638 patients were finally included in this meta-analysis. The results revealed that the use of ventilatory ratio could be significantly related to the mortality in adult ARDS (OR=1.27; 95% CI 1.10 to 1.47; P=0.001). Ventilatory ratio may have the capability of predicting the mortality of NON- COVID-related patients (OR 1.39, 95% CI 1.12 to 1.73 P = 0.003) while it has no predictable significance in patients with COVID (OR 1.18, 95% CI 0.94 to 1.48 P = 0.16). Importantly, the dynamic changes of VR adds more predictable value (OR 1.21 vs 1.19). Conclusion: Our study suggests that ventilatory ratio can be regarded as a valuable marker to predict the mortality of adult patients with ARDS. Compared to patients with COVID, ventilatory ratio is more predictable in patients with NON-COVID. What’s more, the dynamic changes of VR may have the potential to improve the prognostic value.
The Relationship Between Systemic Immune Inflammation Index and Treatment Response in Renal Cell Carcinoma Patients Treated with Tyrosine Kinase Inhibitors: Results from The Turkish Oncology Group Kidney Cancer Consortium Database
Authors: Yücel Kadriye Bir , Yekedüz Emre , Karakaya Serdar , Tural Deniz , Ertürk İsmail , Erol Cihan , Ercelep Özlem , Öztaş Nihan Şentürk , Arslan Çağatay , Uçar Gökhan , Küçükarda Ahmet , Sever Özlem Nuray , Kılıçkap Saadettin , Can Orçun , Yazgan Satı Coşkun , Öksüzoğlu Berna , Karadurmuş Nuri , Şendur Mehmet Ali , Ürün Yüksel 
Published: December 2021

Abstract
Aim: To investigate the prognostic value of the systemic immune-inflammation index (SII) and its impact on survival in patients with metastatic renal cell carcinoma (mRCC).Methods: A total of 706 patients with mRCC treated with tyrosine kinase inhibitors (TKIs) (i.e., sunitinib, pazopanib) were retrospectively analyzed. All patients were classified into either a high-SII group or a low-SII group based on the cut-off value of SII at 756, which was the median SII level of our study group. Results: The median age of patients was 60 (interquartile range (IQR):53-67) years. Three out of four patients were male. The majority of patients (85.7%) had clear cell histology, and sarcomatoid differentiation was observed in 16.9% of all patients. The rates of patients in favorable, intermediate, and poor “International mRCC Database Consortium (IMDC)” risk groups were 20.1%, 57.6%, and 22.2%, respectively. There were 311 and 310 patients in the SII-low and SII-high groups, respectively. At the median of 48.6 months follow-up, the median overall survival (OS) was 34.6 months and 14.5 months in the low- and high-SII groups, respectively (p<0.001). In multivariate analysis, SII was an independent prognostic factor for OS (hazard ratio (HR):1.39, 95% confidence interval (CI):1.05-1.85, p=0.01) and PFS (HR:1.60, 95% CI:1.24-2.05, p<0.001).Conclusion: Pre-treatment level of high SII might be considered as a predictor of poor prognosis in patients with mRCC treated with TKIs.
Comparison of Polysomnographic and Cephalometric Parameters Based on Positional and Rapid Eye Movement Sleep Dependency in Obstructive Sleep Apnea
Authors: Jo Jung-Hwan , Kim Sung-Hun , Jang Ji-Hee , Park Ji-Woon , Chung Jin-Woo 
Published: December 2021

Abstract
The aim of this study is to investigate the differences in polysomnographic and cephalometric features according to positional and rapid eye movement (REM) sleep dependencies in obstructive sleep apnea patients. Standard polysomnography and cephalometric analyses were performed on 133 OSA patients. The subjects were categorized into positional and non-positional, and REM-related and not-REM-related OSA groups according to positional and REM sleep dependency on severity of sleep apnea. Polysomnographic and cephalometric parameters were compared between groups. Positional and REM-related OSA patients showed significantly lower non-supine apnea-hypopnea index (AHI), non-REM (NREM) AHI and overall AHI and higher NREM oxygen saturation (SpO2) and mean SpO2 compared to non-positional and not-REM-related OSA patients, respectively. Cephalometric features between positional and non-positional OSA patients did not show any significant differences. However, REM-related OSA patients showed significantly larger inferior oral airway space and shorter perpendicular distance between mandibular plane and anterior hyoid bone and the distance between uvula and posterior nasal spine, and narrower maximum width of soft palate than not-REM-related OSA patients. Positional and REM-related OSA patients have lower severity of sleep apnea, suggesting the possibility of lower collapsibility of the upper airway. Anatomical factors maybe more closely related to REM sleep than positional dependency.