bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN TEKNIK PENYUSUNAN RAB BAGI PEKERJA DAN TUKANG DI NEGERI NAKU
Authors: Gaspersz Willem , Maelissa Nelda , Latar Sjafrudin 
Published: September 2021

Rencana Anggaran Biaya Merupakan suatu factor yang terpenting dalam pembangunan suatu pekerjaan konstruksi sehingga merupakan hal yang sangat diperlukan bagi para tukang dan pekerja untuk mengetahui berapa besar biaya yang di terimanya pada saat pekerjaan dikerjakan sehingga para tukang harus mengetahui berapa besar biaya yang harus diterimanya. Pengabdian Kepada Masyarakat di Negeri Naku ini ditujukan kepada Tukang dan Pekerja karena awalnya Tukang dan Pekerja Menghitung biaya kerjanya atau estimasi biaya pekerja dengan melakukan perkiraan berdasarkan pengalaman kerja yang mereka lakukan sehingga terjadi ketidak cocokan harga dalam melakukan suatu penawaran biaya kerjanya. Dalam Pelatihan ini diberikan kepada Tukang dan Pekerja untuk mengetahui bagaimana teknik penyusunan Rencana Anggaran Biaya sehingga penawaran biaya tukang kepada Pemilik Pekerjaan dapat diterima sesuai dengan biaya yang di sediakan oleh Pemilik Pekerjaan. Kegiatan Pelatihan Teknik Penyusunan RAB berlangsung selama satu hari yakni padatanggal 13 Oktober 2018. Dalam Melaksanakan Pelatihan kepada Tukang dan Pekerja Tim Pengabdian menggunakan Gambar Bangunan Gedung Lantai 2, Daftar Upah dan Bahan Tahun 2017 Sebagai Dasar dari Perhitungan Analisa harga Satuan, dan Analisa harga Satuan Menggunakan Standar Nasional Indonesia 2008 sebagai dasar untuk Mengetahui Anggaran Biaya Bangunan tersebut. Juga diberikan tugas kepada tukang dan pekerja untuk mengetahui tingkat pemahaman penggunaan Analisa Harga Satuan oleh tukang dan pekerja. Dapat di simpulkan bahwa ternyata sebelum melakukan pelatihan tukang tidak memahami tentang cara penyusunan RAB sehingga menyulitkan untuk memberikan penawaran harga pekerjaan. Dan setelah mendapat pelatihan dari Tim Pengabdian, maka Tukang dan Pekerja tersebut sudah memahami dan dapat menghitung Rencana Anggaran Biaya dengan baik dan benar berdasarkan Standar Naional Indonesia 2008.
Peningkatan Ketrampilan Remaja Putus Sekolah dalam upaya Mengembangkan Usaha Souvenir Gelas Bersablon di Kampung Pulo Geulis Bogor
Authors: Lestari Sri , S Toto , N Benny , Yenniwarti Yenniwarti 
Published: September 2021

Kampung Pulo Geulis, merupakan kampung padat penduduk yang berada di pusat kota Bogor. Kampung ini merupakan destinasi wisata yang dikembangkan Panorama dengan adanya wihara di kampung tersebut. Sayangnya diwilayah tersebut tidak terdapat usaha souvenir yang dapat mendukung wisata tersebut. Usaha Gelas bersablon merupakan usaha yang dapat dimulai dengan skala kecil dan menunjang untuk wisata maupun souvenir pernikahan. Sablon merupakan ketrampilan yang diajarkan pada matakuliah bengkel dasar di Program studi Telekomunikasi PNJ. Dengan ketrampilan yang dikembangkan di prodi Telekomunikasi maka pengabdian kepada masyarakat ditekankan pada bagaimana memproduksi souvenir gelas bersablon. Jenis kegiatan yang akan dilakukan diawali dengan pelatihan usaha membuat gelas bersablon, dengan materi pelatihan antara lain manajemen wirausaha, photoshop menggunakan computer, praktek sablon menggunakan water decal paper pada medium gelas kaca dan keramik. Setelah itu dilanjut dengan pendampingan produksi dan penjualan dari souvenir yang dibuat oleh mitra peserta kegiatan pengabdian kepada masyarakat. Tujuan akhir yang ingin dicapai dari Pengmas ini adalah terbentuk pengusaha souvenir gelas bersablon, sehingga tercipta lapangan kerja baru dan sentra souvenir di Pulo Geulis.
Transcriptome Analysis of Komagataeibacter europaeus CGMCC 20445 Responses to Different Acidity Levels During Acetic Acid Fermentation
Authors: WANG LITING , HONG HOUSHENG , ZHANG CHENGBO , HUANG ZUNXI , GUO HUIMING 
Published: September 2021

Abstract
In the industrial production of high-acidity vinegar, the initial ethanol and acetic acid concentrations are limiting factors that will affect acetic acid fermentation. In this study, Komagataeibacter europaeus CGMCC 20445 was used for acetic acid shake flask fermentation at an initial ethanol concentration of 4.3% (v/v). We conducted transcriptome analysis of K. europaeus CGMCC 20445 samples under different acidity conditions to elucidate the changes in differentially expressed genes throughout the fermentation process. We also analyzed the expression of genes associated with acid-resistance mechanisms. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the differentially expressed genes were enriched in ribosomes, citrate cycle, butanoate metabolism, oxidative phosphorylation, pentose phosphate, and the fatty acid biosynthetic pathways. In addition, this study found that K. europaeus CGMCC 20445 regulates the gene expression levels of cell envelope proteins and stress-responsive proteins to adapt to the gradual increase in acidity during acetic acid fermentation. This study improved the understanding of the acid resistance mechanism of K. europaeus and provided relevant reference information for the further genetic engineering of this bacterium.
Clinical Characteristics of Patients with Micrococcus luteus Bloodstream Infection in a Chinese Tertiary-Care Hospital
Authors: ZHU MINGHUI , ZHU QIANG , YANG ZHEN , LIANG ZHIXIN 
Published: September 2021

Abstract
Few pieces of research have focused on Micrococcus luteus bloodstream infection (BSI) because of its low incidence; hence data is needed to illustrate this uncommon infection. This study aimed to explore the clinical characteristics of patients with M. luteus BSI. From January 2010 to December 2019, inpatients that met the criteria for M. luteus BSI were included in this study. Data was collected by reviewing electronic records. Ninety-seven patients were enrolled in this study. Sixty-three percent of the patients have a higher neutrophil percentage (NEUT%). The average blood C-reactive protein (CRP) concentration was 5.5 ± 6.4 mg/dl. 48.5% of the patients had malignancy, and 40.2% underwent invasive surgeries. Linezolid was found to have the largest average diameter of the inhibition zone (36 mm), while erythromycin was found to have the smallest average zone diameter (15 mm). However, some M. luteus strains had a potentially broad antimicrobial resistance spectrum. Cephalosporins (59.2%) and quinolones (21.4%) were the most commonly used antibiotics for empirical therapies. In conclusion, M. luteus BSI mainly happens in immunocompromised patients or those with former invasive surgeries or indwelling catheters. M. luteus strains are less responsive to erythromycin. Cephalosporins and quinolones are effective empirical antibiotics for M. luteus BSI; however, vancomycin and teicoplanin should be considered for potentially broadly drug-resistant M. luteus strains.
Eğitim Konulu Filmlerin Sınıf Yönetiminin Boyutları Açısından İncelenmesi
Authors: Akcan Emrullah , Kara Mevlüt 
Published: September 2021

Bu araştırmada Millî Eğitim Bakanlığı’nın (MEB) Eylül 2018 dönemi mesleki çalışma programı kapsamında öğretmenlerin izlemesi için önerdiği filmlerin sınıf yönetiminin boyutları açısından incelenmesi amaçlanmıştır. Bu amaç doğrultusunda MEB tarafından önerilen 50 film arasından sınıf içi uygulamaların en yoğun sahnelendiği dört film ölçüt örnekleme tekniği ile seçilmiştir. Nitel olarak tasarlanan bu araştırmada verilerin elde edilmesinde doküman incelemesi; çözümünde betimsel analiz tekniğinden yararlanılmıştır. Araştırma sonucunda, filmlerde sınıf yönetimi açısından öğrencilerin tek kişilik sıralarda oturması, öğretmenlerin derse hazırlıklı ve öğrenciden önce gelmesi, öğrencilere ismi ile hitap etmesi ve sakin, samimi, nezaket kurallarına dikkat eden bir yapıda olmaları gibi olumlu özelliklerin ön plana çıktığı belirlenmiştir. Diğer yandan öğretmen tarafından sınıfın seviyesine uygun olmayan bir metnin okutulması, dersin plansız bir şekilde işlenmesi ve tepkisel sınıf yönetimi modelinin benimsenerek ceza yöntemine başvurulması ise sınıf yönetimini olumsuz etkileyen davranışlar olarak tespit edilmiştir. Filmlerde sınıf yönetimi açısından ortaya çıkan olumlu ve olumsuz davranışlar, öğretmenlik grubu lisans öğrencilerine “Sınıf Yönetimi” derslerinde uygulamalı örnekler olarak sunulabilir.
The Effects of the Intrinsic Motivation and Extrinsic Motivation on Employee Performance with Job Satisfaction as an Intervening Variable at PT. Alwi Assegaf Palembang
Authors: Yusuf Muhammad 
Published: September 2021

This study aimed to examine and analyze the effects of intrinsic motivation and extrinsic motivation on the performance of employees with job satisfaction as an intervening variable at PT. Alwi Assegaf Palembang. The number of respondents was 51 people. The data were collected using a questionnaire method with a Likert scale. They were examined and analyzed using the Smart-partial least square. Furthermore, the intrinsic motivation variable showed a significant positive influence on employee performance, but the extrinsic motivation variable did not have a significant influence on the performance of the employees. Job satisfaction was not an intervening influence between intrinsic motivation and employee performance and between extrinsic motivation and employee performance. The results showed that intrinsic motivation and extrinsic motivation had a significant positive effect on employee job satisfaction. The effect of the intrinsic motivation on the performance was significantly positive, while the extrinsic motivation was not significantly positive on the performance. In this study, job satisfaction was not an intervening variable between the intrinsic and extrinsic motivations on the performance.

Abstrak
Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh motivasi intrinsik dan motivasi ekstrinsik terhadap kinerja karyawan dengan kepuasan kerja sebagai variable intervening pada PT. Alwi Assegaf Palembang. Responden dalam penelitian ini berjumlah 51 orang. Data dalam penelitian ini diperoleh dengan menyebarkan kuisioner berupa pertanyaan dengan menggunakan skala Likert. Data dianalisis dengan smart-partial least square. Hasil penelitian menunjukkan bahwa motivasi intrinsic dan motivasi ekstrinsik berpengaruh positif signifikan terhadap kepuasan kerja karyawan. Pengaruh motivasi intrinsik terhadap kinerja adalah positif signifikan, sedangkan motivasi ekstrinsik menunjukkan tidak ada pengaruh signifikan positif terhadap kinerja. Kepuasan kerja bukan merupakan variabel intervening antara motivasi intrinsik dan ekstrinsik terhadap kinerja dalam penelitian ini.
Kata kunci: Motivasi Intrinsik, Motivasi Ekstrinsik, Kepuasan Kerja, Kinerja
AKR1C3 and Its Transcription Factor HOXB4 Are Promising Diagnostic Biomarkers for Acute Myocardial Infarction
Authors: Liang Jingjing , Cao Yue , He Mingli , Li Weiwen , Huang Guolin , Ma Tianyi , Li Meijun , Huang Yuli , Huang Xiaohui , Hu Yunzhao 
Published: September 2021

Background: A recent study disclosed that ferroptosis was an important myocyte death style in myocardial infarction (MI). However, the diagnostic value of ferroptosis regulators and correlated underlying mechanisms in acute myocardial infarction (AMI) remain unknown.Methods: Bioinformatical analyses were conducted to identify the candidate biomarkers for AMI, and the collected local samples were used to validate the findings via real-time quantitative PCR. Bioinformatical analysis and luciferase reporter assay were implemented to identify the transcriptional factor. Transient transfection and ferroptosis characteristic measurement, including glutathione peroxidase 4, malondialdehyde, iron, and glutathione, was performed to verify the ability of the candidate gene to regulate the ferroptosis of cardiomyocytes. A meta-analysis was conducted in multiple independent cohorts to clarify the diagnostic value.Results: A total of 121 ferroptosis regulators were extracted from previous studies, and aldo-keto reductase family 1 member C3 (AKR1C3) was significantly downregulated in the peripheral blood samples of AMI cases from the analysis of GSE48060 and GSE97320. HOXB4 served as a transcriptional activator for AKR1C3 and could suppress the ferroptosis of the H9C2 cells treated with erastin. Besides this, peripheral blood samples from 16 AMI patients and 16 patients without coronary atherosclerotic disease were collected, where AKR1C3 and HOXB4 both showed a high diagnostic ability. Furthermore, a nomogram including HOXB4 and AKR1C3 was established and successfully validated in six independent datasets. A clinical correlation analysis displayed that AKR1C3 and HOXB4 were correlated with smoking, CK, CK-MB, and N-terminal-pro-B-type natriuretic peptide.Conclusion: Taken together, this study demonstrates that AKR1C3 and HOXB4 are promising diagnostic biomarkers, providing novel insights into the ferroptosis mechanisms of AMI.
Association Between Cardiovascular Risk Factors and the Severity of Coronavirus Disease 2019: Nationwide Epidemiological Study in Korea
Authors: Kong Kyoung Ae , Jung Sodam , Yu Mina , Park Junbeom , Kang In Sook 
Published: September 2021

Background: Acute respiratory viral infections can result in cardiovascular involvement, with such patients having a significantly higher mortality rate than those without cardiovascular involvement. Due to the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is important to determine whether cardiovascular risk factors are associated with the severity of COVID-19.Methods: These nationwide data were provided by the Korea Disease Control and Prevention Agency. We defined a patient as having a “critical illness” if they required more than invasive mechanical ventilation and “fatal illness” if they died.Results: Among the total 5,307 patients, 2,136 (40.8%) were male. The critical illness rate was 5.1% (males: 6.7, females: 4.0%) and the fatality rate was 4.54%. The multivariable analysis showed that age ≥60 years, male sex, diabetes mellitus, hypertension, heart failure, chronic kidney disease, cancer, and dementia were independent risk factors for critical illness. The risk scoring model showed the significance of multiple risk factors. Patients with four risk factors; old age (≥60 years), male sex, hypertension, and diabetes mellitus had a more than a 100 times higher risk for severe COVID-19 than those without these risk factors (OR; 95% confidence interval, 104; 45.6–240.6 for critical, 136.2; 52.3–3547.9 for fatal illness).Conclusions: This study demonstrated that cardiovascular risk factors are also significant risk factors for severe COVID-19. In particular, patients who have multiple cardiovascular risk factors are more likely to progress to severe COVID-19. Therefore, early and appropriate treatment of these patients is crucial.
Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-Inflammatory Cytokines
Authors: Ahuja Shreya , Lazar Iulia M. 
Published: September 2021

BackgroundMicroglia safeguard the CNS against injuries and pathogens, and in the presence of certain harmful stimuli are capable of inducing a disease-dependent inflammatory response. When exposed to anti-inflammatory cytokines, however, these cells possess the ability to switch from an inflammatory to an immunosuppressive phenotype. Cancer cells exploit this property to evade the immune system, and elicit an anti-inflammatory microenvironment that facilitates tumor attachment and growth.ObjectiveThe tumor-supportive biological processes that are activated in microglia cells in response to anti-inflammatory cytokines released from cancer cells were explored with mass spectrometry and proteomic technologies.MethodsSerum-depleted and non-depleted human microglia cells (HMC3) were treated with a cocktail of IL-4, IL-13, IL-10, TGFβ, and CCL2. The cellular protein extracts were analyzed by LC-MS/MS. Using functional annotation clustering tools, statistically significant proteins that displayed a change in abundance between cytokine-treated and non-treated cells were mapped to their biological networks and pathways.ResultsThe proteomic analysis of HMC3 cells enabled the identification of ~10,000 proteins. Stimulation with anti-inflammatory cytokines resulted in the activation of distinct, yet integrated clusters of proteins that trigger downstream a number of tumor-promoting biological processes. The observed changes could be classified into four major categories, i.e., mitochondrial gene expression, ECM remodeling, immune response, and impaired cell cycle progression. Intracellular immune activation was mediated mainly by the transducers of MAPK, STAT, TGFβ, NFKB, and integrin signaling pathways. Abundant collagen formation along with the expression of additional receptors, matrix components, growth factors, proteases and protease inhibitors, was indicative of ECM remodeling processes supportive of cell-cell and cell-matrix adhesion. Overexpression of integrins and their modulators was reflective of signaling processes that link ECM reorganization with cytoskeletal re-arrangements supportive of cell migration. Antigen processing/presentation was represented by HLA class I histocompatibility antigens, and correlated with upregulated proteasomal subunits, vesicular/viral transport, and secretory processes. Immunosuppressive and proangiogenic chemokines, as well as anti-angiogenic factors, were detectable in low abundance. Pronounced pro-inflammatory, chemotactic or phagocytic trends were not observed, however, the expression of certain receptors, signaling and ECM proteins indicated the presence of such capabilities.ConclusionsComprehensive proteomic profiling of HMC3 cells stimulated with anti-inflammatory cytokines revealed a spectrum of microglia phenotypes supportive of cancer development in the brainviamicroenvironment-dependent biological mechanisms.
An Asymmetric Silicon Grating Dual-Narrow-Band Perfect Absorber Based on Dielectric-Metal-Dielectric Structure
Authors: Xu Feng , Lin Lixia , Wei Dongwei , Xu Jing , Fang Jun 
Published: September 2021

With the exhaustion of world energy, new energy has become the most important content of each country’s development strategy. How to efficiently use solar energy has become a research hotspot in current scientific research. Based on surface plasmon resonance and Fabry-Perot (FP) cavity, this paper proposes a design method of asymmetric silicon grating absorber, and uses finite difference time domain (FDTD) method for simulation calculation. By adjusting the geometric parameters, the asymmetric silicon grating absorber realizes two narrow-band absorption peaks with absorption greater than 99% in the optical wavelength range of 3,000–5,000 nm, and the absorption peak wavelengths are λ1 = 3,780 nm and λ2 = 4,135 nm, respectively. When the electromagnetic wave is incident on the surface of the metamaterial, it will excite the plasmon resonance of the metal to form a surface plasmon (SP) wave. When the SP wave propagates along the x axis, the silicon grating can reflect the SP wave back and forth. When the frequency of the SP wave and the incident light are equal, it will cause horizontal FP coupling resonance, resulting in different resonance wavelengths. This paper also discusses the influence of geometric parameters, incident angle and polarization angle on the performance of silicon grating absorbers. Finally, the sensing performance of the structure as a refractive index sensor is studied. The absorber can be used for various spectral applications such as photon detection, optical filtering and spectral sensing.
Visual Explanation for Identification of the Brain Bases for Developmental Dyslexia on fMRI Data
Authors: Tomaz Da Silva Laura , Esper Nathalia Bianchini , Ruiz Duncan D. , Meneguzzi Felipe , Buchweitz Augusto 
Published: September 2021

Problem: Brain imaging studies of mental health and neurodevelopmental disorders have recently included machine learning approaches to identify patients based solely on their brain activation. The goal is to identify brain-related features that generalize from smaller samples of data to larger ones; in the case of neurodevelopmental disorders, finding these patterns can help understand differences in brain function and development that underpin early signs of risk for developmental dyslexia. The success of machine learning classification algorithms on neurofunctional data has been limited to typically homogeneous data sets of few dozens of participants. More recently, larger brain imaging data sets have allowed for deep learning techniques to classify brain states and clinical groups solely from neurofunctional features. Indeed, deep learning techniques can provide helpful tools for classification in healthcare applications, including classification of structural 3D brain images. The adoption of deep learning approaches allows for incremental improvements in classification performance of larger functional brain imaging data sets, but still lacks diagnostic insights about the underlying brain mechanisms associated with disorders; moreover, a related challenge involves providing more clinically-relevant explanations from the neural features that inform classification.Methods: We target this challenge by leveraging two network visualization techniques in convolutional neural network layers responsible for learning high-level features. Using such techniques, we are able to provide meaningful images for expert-backed insights into the condition being classified. We address this challenge using a dataset that includes children diagnosed with developmental dyslexia, and typical reader children.Results: Our results show accurate classification of developmental dyslexia (94.8%) from the brain imaging alone, while providing automatic visualizations of the features involved that match contemporary neuroscientific knowledge (brain regions involved in the reading process for the dyslexic reader group and brain regions associated with strategic control and attention processes for the typical reader group).Conclusions: Our visual explanations of deep learning models turn the accurate yet opaque conclusions from the models into evidence to the condition being studied.