bluuebunny/crossref_metadata_2025_split huggingface dataset:
RvD1 Attenuated Susceptibility to Ischemic AKI in Diabetes by Downregulating Nuclear Factor-κ B Signal and Inhibiting Apoptosis
Authors: Li Zheng , Liu Zhiwen , Lu Hengcheng , Dai Wenni , Chen Junxiang , He Liyu 
Published: July 2021

BackgroundAcute kidney injury (AKI), when occurring in diabetic kidney disease (DKD), is known to be more severe and difficult to recover from. Inflammation and apoptosis may contribute to the heightened sensitivity of, and non-recovery from, AKI in patients with DKD. Resolvin D1 (RvD1) is a potent lipid mediator which can inhibit the inflammatory response and apoptosis in many diseases. However, it has been reported that the RvD1 levels were decreased in diabetes, which may explain why DKD is more susceptible to AKI.MethodsFor animal experiments, diabetic nephropathy (DN) mice were induced by streptozotocin (STZ) injection intraperitoneally. Renal ischemia–reperfusion was used to induce AKI. Blood urea nitrogen (BUN) and serum creatinine were determined using commercial kits to indicate renal function. Renal apoptosis was examined by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay. Real-time polymerase chain reaction (PCR) was used to detect the marker of inflammatory response. Western blot was used to detect the expression of nuclear factor-κB (NF-κB)-related proteins. For clinical study, 12 cases diagnosed with DKD were enrolled in this study, and an equal number of non-diabetic renal disease patients (NDKD) were recruited as a control group. The serum RvD1 in DKD or NDKD patients were detected through an ELISA kit.ResultsIn clinical study, we found that the serum RvD1 levels were decreased in DKD patients compared to those in NDKD patients. Decreased serum RvD1 levels were responsible for the susceptibility to ischemic AKI in DKD patients. In animal experiments, both the serum RvD1 and renal ALX levels were downregulated. RvD1 treatment could ameliorate renal function and histological damage after ischemic injury in DN mice. RvD1 treatment also could inhibit the inflammatory response. Di-tert-butyl dicarbonate (BOC-2) treatment could deteriorate renal function and histological damage after ischemic injury in non-diabetic mice. RvD1 could inhibit the NF-κB activation and suppress inflammatory response mainly by inhibiting NF-κB signaling.ConclusionRvD1 attenuated susceptibility to ischemic AKI in diabetes by downregulating NF-κB signaling and inhibiting apoptosis. Downregulated serum RvD1 levels could be the crucial factor for susceptibility to ischemic AKI in diabetes.
Accuracy of Interpolated Versus In-Vineyard Sensor Climate Data for Heat Accumulation Modelling of Phenology
Authors: Pipan Paula , Hall Andrew , Rogiers Suzy Y. , Holzapfel Bruno P. 
Published: July 2021

Background and AimsIn response to global heating, accurate climate data are required to calculate climatic indices for long-term decisions about vineyard management, vineyard site selection, varieties planted and to predict phenological development. The availability of spatially interpolated climate data has the potential to make viticultural climate analyses possible at specific sites without the expense and uncertainty of collecting climate data within vineyards. The aim of this study was to compare the accuracy and precision of climatic indices calculated using an on-site climate sensor and an interpolated climate dataset to assess whether the effect of spatial variability in climate at this fine spatial scale significantly affects phonological modelling outcomes.Methods and ResultsFour sites comprising two topographically homogenous vineyards and two topographically diverse vineyards in three wine regions in Victoria (Australia) were studied across four growing seasons. A freely available database of interpolated Australian climate data based on government climate station records (Scientific Information for Land Owners, SILO) provided temperature data for grid cells containing the sites (resolution 0.05° latitude by 0.05° longitude, approximately 5 km × 5 km). In-vineyard data loggers collected temperature data for the same time period. The results indicated that the only significant difference between the two climate data sources was the minimum temperatures in the topographically varied vineyards where night-time thermal layering is likely to occur.ConclusionThe interpolated climate data closely matched the in-vineyard recorded maximum temperatures in all cases and minimum temperatures for the topographically homogeneous vineyards. However, minimum temperatures were not as accurately predicted by the interpolated data for the topographically complex sites. Therefore, this specific interpolated dataset was a reasonable substitute for in-vineyard collected data only for vineyard sites that are unlikely to experience night-time thermal layering.Significance of the StudyAccess to accurate climate data from a free interpolation service, such as SILO provides a valuable tool tomanage blocks or sections within vineyards more precisely for vineyards that do not have a weather station on site. Care, nevertheless, is required to account for minimum temperature discrepancies in topographically varied vineyards, due to the potential for cool air pooling at night, that may not be reflected in interpolated climate data.
Family Group Conferences as a Shared Decision-Making Strategy in Adults Mental Health Work
Authors: Ramon Shulamit 
Published: July 2021

Family Group conferences (FGC) provide a system by which a client and their family reach jointly key intervention decisions, from a number of options proposed by professionals. The system originated in child protection social work.Conceptually FGC is based on the assumption that the family is potentially a supportive social system for an individual with a variety of difficulties, including mental ill health. Reaching a family network agreement can lead to long term positive outcomes in self-confidence and social relationships. This strategy of shared decision making (SDM) can re-unite the family around the client's needs and wishes. It fits well the strengths based and the recovery-oriented approaches to mental ill health.Methodologically, this article provides a narrative review of existing empirical research about FGC in the context of adult mental health. In addition, two community case studies consisting of videos of a mother experiencing mental ill health and a daughter are analysed in terms of theirsubjectiveexperience of the FGCs they were involved in, and looks at both the process and the outcomes of FGCs.Thekey findingsdemonstrate a high level of satisfactionfrom participatingin the FGC meeting, while the evidence pertaining to the outcomes is inconclusive. Only very few systematic review studies, or comparative studies of different approaches to family decision making, exist, and there are no studies which offer cost effectiveness analysis.Discussion:The observed gap between the satisfaction from the process of FGC by the participants vs. the inconclusive outcomes relates to the implementation phase, in which the decisions made by the family are tested. Evaluating FGC processes and outcomes is complex. A systematic and comprehensive research of the implementation process is missing at this stage.In conclusion, FGC is a promising strategy of SDM in adult mental health. The research evidence indicates the need for further exploration of its implementation process, evaluative methodology and methods.
Abnormal Degree Centrality in White Matter Hyperintensities: A Resting-State Functional Magnetic Resonance Imaging Study
Authors: Du Baogen , Cao Shanshan , Liu Yuanyuan , Wei Qiang , Zhang Jun , Chen Chen , Wang Xiaojing , Mo Yuting , Nie Jiajia , Qiu Bensheng , Hu Panpan , Wang Kai 
Published: July 2021

Background: White matter hyperintensities (WMHs) are a common occurrence with aging and are associated with cognitive impairment. However, the neurobiological mechanisms of WMHs remain poorly understood. Functional magnetic resonance imaging (fMRI) is a prominent tool that helps in non-invasive examinations and is increasingly used to diagnose neuropsychiatric diseases. Degree centrality (DC) is a common and reliable index in fMRI, which counts the number of direct connections for a given voxel in a network and reflects the functional connectivity within brain networks. We explored the underlying mechanism of cognitive impairment in WMHs from the perspective of DC.Methods: A total of 104 patients with WMHs and 37 matched healthy controls (HCs) were enrolled in the current study. All participants underwent individual and overall cognitive function tests and resting-state fMRI (rs-fMRI). WMHs were divided into three groups (39 mild WMHs, 37 moderate WMHs, and 28 severe WMHs) according to their Fazekas scores, and the abnormal DC values in the WMHs and HCs groups were analyzed.Results: There was a significant difference in the right inferior frontal orbital gyrus and left superior parietal gyrus between the WMHs and HCs groups. The functional connectivity between the right inferior frontal orbital gyrus and left inferior temporal gyrus, left superior parietal gyrus, and left parietal inferior gyrus was also different in the WMHs group.Conclusion: The change in DC value may be one of the underlying mechanisms of cognitive impairment in individuals with WMHs, which provides us with a new approach to delaying cognitive impairment in WMHs.
Prevalence and Risk Factors of Mental Health Symptoms and Suicidal Behavior Among University Students in Wuhan, China During the COVID-19 Pandemic
Authors: Xu Yingying , Su Sizhen , Jiang Zhendong , Guo Suihuai , Lu Qingdong , Liu Lin , Zhao Yimiao , Wu Ping , Que Jianyu , Shi Le , Deng Jiahui , Meng Shiqiu , Yan Wei , Sun Yankun , Yuan Kai , Lin Xiao , Sun Siwei , Ravindran Arun V. , Chen Sijing , Wing Yun Kwok , Tang Xiangdong , Ran Maosheng , Lu Yu , Shi Jie , Huang Guofu , Bao Yanping , Lu Lin 
Published: July 2021

Background: University students who are exposed to coronavirus disease 2019 (COVID-19) could be mentally distressed. We aimed to evaluate the pattern and risk factors of mental health and suicidal behavior among students who experienced long-term school closure due to the COVID-19 pandemic.Methods: This large-sample, cross-sectional, online survey was conducted from June 29, 2020, to July 18, 2020. Eleven thousand two hundred fifty four participants were recruited from 30 universities located in Wuhan, Hubei Province, China. The prevalence of symptoms of depression, anxiety, insomnia, and posttraumatic stress disorder (PTSD) and suicidal behavior was evaluated using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Insomnia Severity Index, Posttraumatic Stress Disorder Checklist for DSM-5, and questions about suicidal ideation and attempts, respectively. Logistic regression was used to explore risk factors for mental health problems and suicidal behavior.Results: The prevalence of mental health problems was 41.5% for depressive symptoms, 32.6% for anxiety symptoms, 35.0% for insomnia symptoms, 8.5% for PTSD symptoms, and 2.0% for suicidal behavior. Participants with high stress during the pandemic were at higher risk of symptoms of depression [adjusted odds ratio (OR) = 1.67, 95% confidence interval (CI) = 1.43–1.95, p &lt; 0.01), anxiety (adjusted OR = 1.90, 95% CI = 1.63–2.23, p &lt; 0.01), insomnia (adjusted OR = 1.64, 95% CI = 1.44–1.87, p &lt; 0.01), PTSD (adjusted OR = 1.71, 95% CI = 1.38–2.11, p &lt; 0.01) and suicidal behavior (adjusted OR = 3.51, 95% CI = 2.28–5.40, p &lt; 0.01). Distant relationship with parents, changes in lifestyle and alcohol use during the pandemic were associated with higher risk of mental health symptoms and suicidal behavior, whereas regular physical exercise reduced the risk of mental health problems.Conclusions: The psychological symptoms and suicidal behavior were relatively high among students who attended university in Wuhan, China after 6 months of the COVID-19 outbreak in China. Comprehensive mental health services and suicide prevention strategies are essential for university students during the COVID-19 pandemic.
Antibiotic Susceptibility Profile of Pseudomonas aeruginosa Canine Isolates from a Multicentric Study in Romania
Authors: Dégi János , Moțco Oana-Alexandra , Dégi Diana Maria , Suici Tiana , Mareș Mihai , Imre Kalman , Cristina Romeo Teodor 
Published: July 2021

Treating infections caused by Pseudomonas aeruginosa is increasingly difficult due to high antibiotic resistance, materialized through the presence of multiple resistance strains, as well as due to rapid development of resistance throughout treatment. The present survey was conducted to investigate the antibiotic susceptibility profile of Pseudomonas aeruginosa pathogens in two University Veterinary hospitals from different geographical regions of Romania (i.e., Southwest Timișoara county and Northeast Iași county) involved in superficial canine infections. A total of 142 swab specimens were collected from dogs with superficial infections (superficial skin infections, otitis externa, and perianal abscess) to assess the presence of Pseudomonas aeruginosa, based on phenotypic and molecular characterization. According to their confirmed morphological and molecular features, 58 samples (40.84%; 58/142) were positive for Pseudomonas aeruginosa (according to their confirmed morphological and molecular features). Antibiotic susceptibility testing for 12 antibiotics was conducted using the Kirby–Bauer disc diffusion method. Drug resistance was observed in the case of all tested antibiotics. The susceptibility rate of P. aeruginosa strains that were tested in this study was in the following order: ceftazidime (53.44%; 31/58), followed by aztreonam (51.72%; 30/58), amikacin (44.82%; 26/58), azithromycin (41.37%; 24/58), gentamicin (37.93%; 22/58), cefepime (36.20%; 21/58), meropenem (25.86%; 13/58), piperacillin-tazobactam (25.86%; 13/58), imipenem (22.41%; 13/158), ciprofloxacin (17.24%; 10/58), tobramycin (8.62; 5/58), and polymyxin B (1.72; 1/58). The results highlight the importance of antibiotic susceptibility testing in Pseudomonas aeruginosa isolates from dogs with superficial infections to use an adequate treatment plan to manage the skin condition and other pathologies (otitis externa and perianal abscesses).
HEALTH PRECAUTIONS WHEN USING RADIATING MOBILE DEVICES
Authors: Зубарев Ю.Б. , Григорьев Ю.Г. , Григорьев О.А. 
Published: July 2021

Показано, что рост числа пользователей мобильными телефонами повышает вероятность влияния электромаг- нитного поля (ЭМП) на здоровье человека в масштабах населения страны. Обоснованы практические решения для снижения персонального риска здоровью при использовании мобильных телефонов и смартфонов. Предложены практические рекомендации по соблюдению элементарных гигиенических принципов при работе с мобильным телефоном, которые необходимо доводить до каждого пользователя, что поможет ему осознанно выбирать режим работы мобильных устройств.
It is shown that an increase in the number of users of mobile phones increases the probability of the influence of the electromagnetic field on human health across the countrys population. Practical solutions to reducing personal risk to health when using mobile phones and smartphones are substantiated. Practical recommendations are offered for observing basic hygiene principles when working with a mobile phone, which must be brought to each user, which will help him to consciously choose the mode of use of mobile devices.
INFLUENCE OF A PRIORI INFORMATION ON THE MULTIPLE MODEL ALGORITHM CONVERGENCE DURING TRACKING A BALLISTIC TARGET
Authors: Голенко Д.С. , Сычев М.И. 
Published: July 2021

Рассмотрена задача сопровождения маневрирующего баллистического объекта на этапе входа в атмосферу с помощью пассивной антенной решетки. Предложено использовать многомодельный алгоритм на основе расширенного и сигма-точечного фильтров Калмана. Проанализировано влияние точности априорной информации на сходимость многомодельного алгоритма. С помощью математического моделирования проведено сравнение с одиночными фильтрами Калмана.
The problem of reentry ballistic target tracking with a passive antenna array is considered. Multiple model algorithm based on extended and sigma-point Kalman filters is proposed. A priori information accuracy influence on the convergence of multiple model algorithm is analyzed. Using mathematical modeling, the results were compared with regular extended Kalman filters.
COLUMBUS OF RADIO ENGINEERING. TO THE 125th ANNIVERSARY OF RADIO INVENTION. PART I
Authors: БОРИСОВА Н.А. 
Published: July 2021

Приведены доказательства того, что изобретение, публично продемонстрированное русским ученым-физиком А.С. Поповым 7 мая 1895 г., положило начало беспроводной связи. Рассмотрены следующие вопросы: что произошло в эту знаменательную дату на чьих работах базировался Попов, создавая схему беспроводной связи. Показаны сущность и новизна технического решения. Опровергается ошибочное мнение о том, что 25 апреля (7 мая) 1895 г. А.С. Попов официально пред- ставил грозоотметчик. Для сравнительной оценки вклада Попова и его предшественников в изобретение радио использован синергетический подход кроме того, возникновение и развитие радиосвязи представлены в виде последовательности этапов инновационного процесса. В условиях, когда национальные интересы и общий скепсис в отношении того, что у радио есть изо- бретатель, привели к появлению понятий коллективный разум , пионеры радиосвязи и их список с годами растет (в наши дни во многих странах есть свой Попов ), популяризация научно обоснованных сведений о Попове как о первооткрывателе радио Колумбе радиотехники приобретает особую важность.
The article presents the evidence that the invention, publicly demonstrated by the Russian physicist A.S. Popov on May 7 (new style), 1895, marked the beginning of wireless communication. The following questions are discussed. What happened on that date On whose works Popov was based, creating a wireless communication scheme The core and novelty of the technical solution are described. A misconception that on May 7, 1895, A.S. Popov publicly presented the lightning detector is disputed. For a comparative analysis of Popovs and predecessorss contribution to the radio invention a synergetic approach is used.
DOPPLER FREQUENCY SHIFT ESTIMATION BASED ON THE FIRST- AND SECOND-ORDER DIFFERENCE PHASES
Authors: Егоров В.В. , Лобов С.А. , Маслаков М.Л. , Мингалев А.Н. 
Published: July 2021

Рассмотрена задача оценки доплеровского смещения несущей частоты информационного одночастотного фа- зоманипулированного сигнала, если информационная последовательность неизвестна. Приведено описание метода оценки с использованием разности фаз первого и второго порядков. Представлены результаты численного моделирования.
The problem of Doppler frequency shift estimation of the single-tone information signal with phase-shiftkeying modulation under conditions when the information sequence is unknown is considered. The description of the estimation method using the firstand second-order phase difference is given. The results of the numerical simulation are presented.
ANALYSIS OF INVERSE CLASS-F POWER AMPLIFIER WITH FORMING LINE
Authors: Воронович В.В. , Гадзиковский А.Г. , Потапов А.Ю. 
Published: July 2021

Приводятся результаты исследования усилителя мощности (УМ) инверсного класса F с отрезком формирующей линии. В нормированном (обобщенном) виде устанавливается связь энергетических и диапазонных характеристик с параметрами схемы. Показано, что в области высоких частот данный УМ по энергетическим характеристикам превосходит УМ других классов.
Results of the study of the inverse class-F power amplifier with forming line segment are given. The connection of energy and band characteristics with the circuit parameters in normalized form is established. The results show that this power amplifier is superior in energy characteristics in the high-frequency band to power amplifiers of other classes.
ANALISIS PENGGUNAAN DANA TATA KELOLA DESA (STUDI KASUS DI KECAMATAN IV NAGARI BAYANG UTARA KABUPATEN PESISIR SELATAN)
Authors: Iasra Miftahul Fikri , Erwin Erwin , Syarfi Wahyuni 
Published: July 2021

ABSTRAKTujuan penelitian adalah untuk mendeskripsikan dana Desa dari segi aspek, khususnya 1) Partisipasi. 2) Transparansi. 3) Akuntabilitas. 4) Efektivitas. Penelitian ini dilakukan di 6 Nagari di Kecamatan IV Nagari Bayang Utara Kabupaten Pesisir Selatan. Jenis-jenis catatan yang diperoleh dalam pembelajaran ini diambil dari dua sumber, terutama informasi fundamental dan data sekunder. Teknik analisis data yang diperoleh dalam mencari tahu dianalisis dengan menggunakan analisis evaluasi fakta kualitatif. Hasil penelitian yang telah dilakukan dapat dibuktikan dari 1) Penerapan transparansi oleh pemerintah nagari cukup baik dalam Pengelolaan Dana Desa. 2) Implementasi Akuntabilitas dalam Pemerintahan Penggunaan dana Desa oleh pemerintah desa cukup baik. 3) Pelaksanaan partisipasi pemerintah desa yang ada belum maksimal pada saat adanya Undangan Nagari Musrembang untuk menentukan arah pengembangan nagari dalam penggunaan dana desa, belum 100% tetapi baru menyentuh 71,4% masyarakat yang hadir di musrembang nagari. 4) Penerapan efektifitas pengelolaan dana desa yang dilakukan oleh pemerintah desa di Kecamatan IV Nagari Bayang Utara Kabupaten Pesisir Selatan telah melaksanakan efisiensi dan penghematan dalam penggunaan dana dan alokasi dana lebih berorientasi pada kepentingan masyarakat. Kata kunci: Tata Kelola. Dana DesaABSTRACTThe purpose of the study is to describe of Village Funds in terms of aspects, in particular 1) Participation. 2) Transparency. 3) Accountability. 4) Effectiveness. This research was conducted in 6 Nagari in District IV Nagari Bayang Utara, Pesisir Selatan Regency. The types of notes obtained in this study were taken from two sources, mainly fundamental information and secondary data. The data analysis technique obtained in finding out was analyzed using qualitative fact evaluation analysis. The results of the research that have been carried out can be proven from 1) The implementation of transparency by the nagari government is quite good in Village Fund Management. 2) Implementation of Accountability in Government The use of Village funds by the village government is quite good. 3) The implementation of existing village government participation has not been maximized at the time of the Nagari Musrembang invitation to determine the direction of nagari development in the use of village funds, not yet 100% but only touching 71.4% of the people who attend the Nagari Musrembang. 4) The implementation of the effectiveness of village fund management carried out by the village government in District IV Nagari Bayang Utara, Pesisir Selatan Regency has implemented efficiency and savings in the use of funds and the allocation of funds is more oriented to the interests of the community.Keywords: Governance. Village Fund