bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why pledges alone will not get plastics recycled – Comparing recyclate production and anticipated demand
Authors: Kahlert Sebastian , Bening Catharina 
Published: November 2021

Abstract
Scientific analysis and media coverage of rampant plastic pollution has taken a toll on the material’s reputation in recent years, fueling talk of a “plastic crisis.” Brand owners have made ambitious pledges to overcome this crisis—but can voluntary commitments turn the tide? In this paper, we analyze the current flow of polyethylene terephthalate (PET) from production to recycling in the European Union (EU). We show that the pledged volume for recycled PET to be used in the EU in 2025 amounts to 2.066m tons, requiring the annual recycling growth rate to double in the next years compared to 2014–2018. Our results indicate that even widespread adoption of deposit return systems for bottles will not suffice, especially when increasing demand from other industries drives the price above the packaging producers’ willingness to pay. To realize the pledges, substantial investments and a regulatory framework for the targeted and sensible use of PET recyclate are necessary.
MLL-SEPT6 Positive Acute Myeloid Leukemia Patients Often Co-occur With NRAS Mutations?
Authors: Chen Fang , Yang Ying , Fu Shuang 
Published: November 2021

Abstract
BackgroundThe MLL-SEPT6 fusion gene is a relatively rare genetic event in leukemia. Its clinical characteristics, prognosis, especially the profile of co-occurring gene mutations remain unclear. MethodsWe retrospectively analyzed four rare leukemia cases carrying MLL-SEPT6 in our hospital from laboratory examination, diagnosis, treatment and prognosis, and provided a comprehensive and detailed description on clinical profile of MLL-SEPT6-positive AML patients in the literature. ResultsAll the four patients were diagnosed with acute myeloid leukemia (AML) and harbored X chromosome and 11 chromosome rearrangements. Three of four cases occurred NRAS mutation while the rest one with congenital AML did not. Of the four cases, one developed drug-resistant, one suffered relapse after bone marrow transplantation (BMT) and one died. Combined with other cases reported in literatures, we found that of all patients diagnosed with AML, 90.9% were children (≤ 9 years old) and 54.5% were infants (≤1 year old). The survival time between infant group (≤1 year old) and pediatric group (>1 and <18 years old), patients that received BMT and that received chemotherapy alone did not show significant differences (P>0.05). ConclusionsMLL-SEPT6 was more commonly observed in pediatric AML patients, some of which may co-occur with NRAS mutations. The prognosis was inconclusive and may not be related to age or BMT. More information needs to be accumulated and summarized from additional cases to confirm the underlying connection between NRAS mutations and MLL-SEPT6 in order to better understand the profile in MLL-SEPT6-positive AML.
Single-cell Transcriptome Analysis Uncovers Heterogeneity and Key Regulators in Ibrutinib-resistant Chronic Lymphocytic Leukemia
Authors: Jin Hui , Huang Bin , Wu Zijuan , Zhu Huayuan , Tang Hanning , Wu Jiazhu , Gu Danling , Cai Yun , Wang Luqiao , Lu Xueying , Xu Wei , Li Kening , Wang Qianghu , Li Jian-yong 
Published: November 2021

Abstract
BackgroundIbrutinib as a widely used Bruton’s tyrosine kinase inhibitor has shown outstanding value in clinical therapy for chronic lymphocytic leukemia (CLL). However, the bottleneck of ibrutinib resistance has caused widespread concerns, necessitating the exploration of novel targets. MethodsSingle-cell RNA sequencing (scRNA-seq) was used to characterize the heterogeneity of ibrutinib-sensitive (IBS) and -resistant (IBR) CLL patients and single-cell stemness estimation and metabolic pathway enrichment analysis were performed. Lectin galactoside-binding soluble 1 (LGALS1) and lymphocyte-activating gene 3 (LAG3) were screened as key factors by analyzing the RNA-sequencing data at bulk and single cell levels. Subsequently, pseudo-time trajectory analysis and gene set enrichment analysis were conducted. In addition, an IBR CLL cell line (MEC1-IR) was generated and RT-qPCR, western blotting, and immunofluorescence were performed to detect the expression of LGALS1 and LAG3. OTX008, a selective inhibitor of galectin-1 (Gal-1, encoded by LGALS1) was assessed in CLL cells and CCK8 and apoptotic assays were conducted for functional analysis.ResultsIBR CLL showed significantly different characteristics from IBS in terms of transcriptome expression and energy metabolism. LGALS1 and LAG3 were gradually upregulated in B cells along the evolution trajectory from IBS to IBR. Their expression was verified to be closely related to the prognosis of CLL, as well as sensitivity to ibrutinib. OTX008 could effectively suppress the proliferation and induce apoptosis of CLL cells, especially for those with ibrutinib resistance.ConclusionsAn LGALS1 and LAG3 gene panel is a promising indicator of ibrutinib resistance and a prognostic marker for CLL. OTX008 displays pronounced performance against CLL cells, especially with IBR, and might represent a novel therapeutic strategy for CLL.
Islamic Indonesian EFL students’ responses on English-speaking countries
Authors: Yustina Luli Sari , Sukandi Syayid Sandi , Arniman Nurkhairat 
Published: November 2021

EFL students learn English within the notion of English as an international language. The gap in this research is to study the learning of English as a language to the study of the culture of the English-speaking countries. This gap emerged after cross-culture understanding was taught in a one-semester course at an Islamic state university in Indonesia. Phenomenology is the theory used in this research, within the qualitative research approach and descriptive statistics. 110 respondents were given the questionnaires, with open-ended questions asking four interrelated questions about the United States of America, the United Kingdom, and Australia as the three English-speaking countries. The respondents’ answers in the questionnaire were analysed by using codes, or themes, that later on show the frequency of each theme. The answers were categorized according to the themes and the percentage based on frequency. Thus, the findings of this research highlighted that Indonesian Muslim students have certain themes when looking at English-speaking countries, such as the United States of America, the United Kingdom, and Australia when they learn English as a foreign language.
PELATIHAN PENERAPAN MODEL PEMBELAJARAN PENEMUAN TERBIMBING UNTUK MENEMUKAN LUAS BANGUN DATAR BAGI GURU SD DI KKG GUGUS I KECAMATAN SIRENJA KABUPATEN DONGGALA
Authors: Sugita Gandung , Anggraini Anggraini , Rochaminah Sutji , Jaeng Maxinus 
Published: November 2021

Pelatihan yang dilakukan dalam kegiatan pengabdian kepada masyarakat ini adalah penerapan salah satu model dalam pembelajaran matematika, yaitu model pembelajaran penemuan terbimbing. Model ini diwajibkan dalam Kurikulum 2013. Melalui model ini diharapkan siswa menemukan sendiri konsep-konsep matematika khususnya luas bangun datar, sehingga ilmu tersebut tidak hanya dihafal tapi di pahami dengan baik. Oleh karena itu, tim pengabdian melakukan kegiatan ini dengan tujuan untuk membantu guru-guru SD di KKG Gugus I kecamatan Sirenja kabupaten Donggala dalam penerapan model pembelajaran penemuan terbimbing sesuai amanat Kurikulum 2013. Model pembelajaran penemuan terbimbing yang disimulasikan oleh tim Pengabdian, yaitu menemukan luas bangun datar yang meliputi: persegi, persegi panjang, segitiga, jajargenjang, belahketupat, trapesium dan lingkaran. Penerapan model ini menggunakan karton sebagai alat peraga, yang dapat dibentuk menjadi bangun datar.
Berdasarkan hasil angket, diperoleh: 45,83% guru menyatakan sangat setuju bahwa materi tentang Model Pembelajaran Penemuan Terbimbing yang disampaikan, memberikan pemahaman yang baik tentang langkah-langkah pembelajaran penemuan terbimbing, dan 54,17% guru menyatakan setuju. Selain itu, 54,17% guru menyatakan sangat setuju bahwa Penerapan Model Pembelajaran PenemuanTerbimbing pada materi menemukan luas bangun datar yang disimulasikan, dapat menumbuhkan motivasi dan keaktifan siswa dalam pembelajaran, serta menciptakan pembelajaran yang tidak hanya menghafal rumus luas tetapi mampu menemukan rumus tersebut, dan 45,83% guru menyatakan setuju.
Recent Advancements in Emerging Neuromorphic Device Technologies
Authors: Woo Jiyong , Kang Heebum , Kim Hyun Wook , Hong Eun Ryeong 
Published: November 2021

The explosive growth of data and information has motivated technological
developments in computing systems that utilize them for efficiently
discovering patterns and gaining relevant insights. Inspired by the
structure and functions of biological synapses and neurons in the brain,
neural network algorithms that can realize highly parallel computations
have been implemented on conventional silicon transistor-based hardware.
However, synapses composed of multiple transistors allow only binary
information to be stored, and processing such digital states through
complicated silicon neuron circuits makes low-power and low-latency
computing difficult. Therefore, the attractiveness of the emerging
memories and switches for synaptic and neuronal elements, respectively,
in implementing neuromorphic systems, which are suitable for performing
energy-efficient cognitive functions and recognition, is discussed
herein. Based on a literature survey, recent progress concerning
memories shows that novel strategies related to materials and device
engineering to mitigate challenges are presented to primarily achieve
nonvolatile analog synaptic characteristics. Attempts to emulate the
role of the neuron in various ways using compact switches and volatile
memories are also discussed. It is hoped that this review will help
direct future interdisciplinary research on device, circuit, and
architecture levels of neuromorphic systems.
Corresponding author(s) Email: jiyong.woo@knu.ac.kr
FAKTOR - FAKTOR YANG MEMPENGARUHI KONSUMSI LISTRIK DI INDONESIA
Authors: Rosadi Mutia , Amar Syamsul 
Published: November 2021

This research aims to examine the factors that influence the consumption for electricity in Indonesia with the selected model is the Fixed Effect Model (FEM). The data used is panel data during the period 2014-2017, with the technique of collecting documentation data and library studies obtained from relevant institutions and agencies.The variables use are electricity tariff, income, number of household customer, and number of industrial customer. The research method used is Ordinary Least Square (OLS). The estimation results show that, electricity tariff have a negative and its not significant effect on the electricity consumption in Indonesia.s. Income, household customer, and industrial customer have a positive and significant effect on the electricity consumption in Indonesia. Meanwhile simultaneously electricity tariff, income, number of household customer, and number of industrial customer affect the electricity consumption in Indonesia.
ANALISIS KAUSALITAS KRIMINALITAS, PENDIDIKAN DAN KEMISKINAN DI INDONESIA
Authors: Sari Nadya Centia , Azhar Zul 
Published: November 2021

This study aims to examine the causality of crime, education and poverty in Indonesia. The data used is panel data during the period 2013-2017, with the technique of collecting documentation data and library studies obtained from relevant institutions and agencies. The variables used are Crime (Y1), Education (Y2), Poverty (Y3). The research methods used are: Granger Causality Test Panel and Vector Autoregression (PVAR) Panel. This study found that crime does not have a causal relationship to education, and vice versa. Crime does not have a causal relationship to poverty and vice versa. And poverty has a one-way relationship to education. The results of the PVAR found that crime in a given year period was significantly influenced by crime in the previous period. Likewise, it was also with education and poverty.
ANALISIS DETERMINAN TENAGA KERJA TERDIDIK YANG BEKERJA PADA LAPANGAN PEKERJAAN NON PRIMER DI SUMATERA BARAT
Authors: Putri Krismay , Aimon Hasdi 
Published: November 2021

This study explain the determinants of educated workforce who work on the non primary employment in West Sumatra.The data used is cross section in 2018. The variables used this study are non primary employment, educated, age, work experience, residence and gender. This model uses multiple logistic regression analysis. The result shows tha: 1) educated hasQa positiive and siignificant efffect on the non pimary employmeent 2) age of workforce educated hasYa poositive and not siignificant effect on the non primary employment. 3) work experiience has a possitive and siignificant efffect on the non primary employment 4) residence has a positive and significant effect on the non primary employmen. 5) gender haas a poositive and siignificant effeect on the non primary eemployment.
PENGARUH PENDIDIKAN, JUMLAH JAM KERJA, UMUR TERHADAP UPAH TENAGA KERJA DISABILITAS DI SUMATERA BARAT
Authors: Putri Salwa Nabila , Ariusni Ariusni 
Published: November 2021

This study aims to find out determine of wages for disabled workers in Sumatera Barat. This research use cross section with 481 samples. The variables used are wage for disabled workers,education, number of hours worked, age, work experience, type of work. This research’s methods used Ordinary Least Square (OLS) Multiple linear regression analysis. This research show education, number of work, work experience had significanlly positive effect on wage for disabled workers in Sumatera Barat. Type of work has significanlly negative effect on wage for disabled worker, age had nonsignificanly positive effect on wage for disabled.
ANALISIS PENGARUH INFRASTRUKTUR EKONOMI DAN UPAH TERHADAP PENANAMAN MODAL ASING DI PULAU SUMATERA
Authors: Pratiwi Sonia , Triani Mike 
Published: November 2021

This study aims to find out and analyze: (1) The impact road infrastructure on FDI in Sumatera Island. (2) The impact of electricity infrastructure on FDI in Sumatera Island. (3)The impact of telecommunication infrastructure on FDI in Sumatera Island (4) The impact of wage on foreign direct investment in Sumatera Island. (5) The impact of road infrastructure, electricity infrastructure, telecommunication infrastructure and wage on FDI in Sumatera Island. This study used a panel regression analysis with model selected is the Random Effect Model (REM). The results of this study indicate that (1) Road Infrastructure has no impact on FDI in Sumatera Island. (2) Electricity infrastructure has an impact on FDI in Sumatera Island. (3) Telecommunication infrastructure has an impact on foreign investment in Sumatera Island. (4) Wage has no impact on FDI in Sumatera Island, while (5) Together road infrastructure, electricity infrastructure, telecommunication infrastructure and wage has an impact on FDI in Sumatera Island.
ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI PENAWARAN TENAGA KERJA DI INDONESIA
Authors: Andrisani Elsa , Triani Mike 
Published: November 2021

the phenomenon of labor in Indonesian is that the workforce in increasing but there are few opportunities for employment. This will cause unemployment and many unemployment will effect the economy. Study aims to determine the impact of population growth , wages, and education on labor supply in Indonesia. This research used panel data from 2013 to 2018 in 34 provinces in Indonesia and analysis used panel data regression with FEM method. The results of the study found that; 1) population growth hasn’t impact on the labor supply in Indonesia. (2) Wages hasn’t impact on labor supply in Indonesia. (3) education has an impact on the labor supply in Indonesia.
Faktor-Faktor yang Mempengaruhi Tenaga Kerja Wanita Menikah Menggunakan Alat Kontrasepsi di Sumatera Barat
Authors: Simatupang Putri Diana Kristina , Satrianto Alpon 
Published: November 2021

This study aims to determine: (1) the effect of he education level of married women on the use of contraceptives on married women workers in West Sumatra Province. (2) the effect of the type of work on the use of contraceptives on married female workers in West Sumatra. (3) the effect in the area of residence on thee use oof contraceptives on thee labor oof married women in West Sumatra.(4) the effect of working hours on the use of contraceptives married female workers in West Sumatra. (5) the effect of income on the use of contraceptives on the labor of woman married in West Sumatera. This research uses data from the National Social Economic Survey (SUSENAS) in 2018. The analysis tool used is logistic regression analysis, and the total number of respondents is 8251 people. The result of the studying indicated that(1) thee level of education has a significant negative effect on the opportunities for married female workers to use contraceptives in West Sumatra, (2) the type of work has no significant negative effect on the opportunities for married womens works to use contraceptives in West Sumatra, (3) the area of residence dooesn’t have a significant positive effect on the opportunities for married female workers to use contraception in West Sumatra, (4) working hours has a siginificant and positive effect on the opportunities for married womens works to use contraception in West Sumatra, (5) income Not a significant positive effect on employment opportunities for married women in using contraceptives in West Sumatra.
Analisis Kausalitas Infrastruktur Telekomunikasi, Pertumbuhan Ekonomi dan Pembangunan Ekonomi di Indonesia
Authors: Khaira Annisa , Ariusni Ariusni 
Published: November 2021

This research explains about Analysis of causality beetwen Telecommunications Infrastructure, Economic Growth And Economic Development in Indonesia. This research uses a panel data start from 2012 – 2017,consisting of 33 province in Indonesia with proccessing method that use PVAR. Data was obtained from BPS report in every years. Reaserch results explain that (1) Telecommunications infrastructure has no causality influence one direction or two direction to economic to economic growth in Indonesia (2) Telecommunications infrastructure has causality influence one or two direction to economic to economic growth in Indonesia (3) Economic growth has no causality influence one direction or two direction economic development in Indonesia.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI STATUS KEMISKINAN RUMAH TANGGA PROVINSI SUMATRA BARAT
Authors: Hidayat Rahmat , Amar B Syamsul 
Published: November 2021

This research was conducted to: (1) Determine the influence of gender on household poverty in West Sumatra. (2) Knowing the effect of education level on household poverty in West Sumatra. (3) Knowing the effect of Main Work on household poverty in West Sumatra (4) Knowing the effect of the number of household members on household poverty in West Sumatra. This research is descriptive and associative. The data used is the SUSENAS year sourced from the BPS of West Sumatra Province. The method uses Logistic Regression Analysis.The results of the study are: (1) Gender has a significant positive effect on the level of household poverty in West Sumatra, the head of the household is headed by a man. -men are more likely to be poor than households headed by women in West Sumatra. (2) The level of education has a significant negative effect on the level of poverty in West Sumatra, the increase in the level of education completed by the head of the family, the less likely it is for the household to become poor. (3) Main employment has a significant positive effect on poverty levels in West Sumatra. (4) The number of household members also has a significant positive effect on the level of household poverty in West Sumatra.Based on this research, the authors suggest to the West Sumatra Provincial Government to develop human resources in advance so that all potential areas can be maximized, and will be able to support the level of community welfare in West Sumatra. Keywords: Gender, Education, Main job, Number of Household Members, Logistic Regression.
Gestão do conhecimento para o planejamento estratégico na pandemia: um estudo de caso em um observatório de cooperativas
Authors: Damian Ieda Pelógia Martins , Santos Beatriz Rosa Pinheiro dos , Falcão Nidelson Teixeira , Moura Costa Davi Rogério de 
Published: November 2021

O conhecimento tem ocupado posições de destaque nas organizações por possibilitar a construção de vantagens competitivas sustentáveis. Diante da importância deste recurso, sua gestão passa a ser fundamental, uma vez que contribui para que os objetivos organizacionais sejam alcançados. Estes objetivos são definidos durante a execução das atividades do planejamento estratégico, que se propõe a direcionar as organizações para que resultados pretendidos sejam alcançados. Estas atividades se fazem ainda mais importantes em momentos de crise, como os vivivos pela pandemia do COVID-19. Foi neste cenário pandêmico que o Observatório de Cooperativas da Universidade de São Paulo, por meio da utilização de tecnologias de informação e comunicação, desenvolveu seu planejamento estratégico. Perante ao exposto, este estudo tem por objetivo destacar as contribuições da gestão do conhecimento para o planejamento estratégico, uma vez que tais ferramentas se tornam ainda mais essenciais em momentos de crise como os vividos em uma pandemia. Como procedimentos metodológicos, se fez uso do estudo de caso que permite, além de relacionar teoria e pratica, demonstrar o contexto do observatório onde as atividades foram desenvolvidas. Como resultados, se destaca que as contribuições advindas da gestão do conhecimento, como o desenvolvimento de um ambiente colaborativo, do trabalho em equipe, da motivação, da autonomia, entre outros, foram essenciais para o desenvolvimento do planejamento estratégico do Observatório em meio a pandemia do COVID-19.
LEMON FLAVORED CLEANER TO PROTECT THE SOCIETY ON LARGE-SCALE SOCIAL RESTRICTIONS IN PADANG CITY, WEST SUMATERA PROVINCE
Authors: Ismed Ismed , Yenrina Rina , Anggraini Tuty , Silvy Diana , Efrina Efrina 
Published: November 2021

Background: The corona pandemic has wreaked havoc all across the world, especially in Indonesia. Hand washing with soap or hand sanitizer is one approach to help prevent the transmission of the corona virus. To aid in the prevention of the corona virus, a variety of hand sanitizers have been developed. Methodology: Therefore, hand sanitizers made from alcohol with lemon aroma have been produced and distributed to the community around the residence of the academic community of Andalas University. This hand sanitizer is made independently using ingredients such as alcohol, glycerin, water, hydrogen peroxide and lemon extract. Conclusion: The distributed hand sanitizer is highly accepted by the community because of the increasing need for personal hygiene due to the increasingly massive spread of the corona virus. It is hoped that this activity can be done continuously.