bluuebunny/crossref_metadata_2025_split huggingface dataset:
The permanent tide and the International Height Reference Frame IHRF
Authors: Mäkinen Jaakko 
Published: September 2021

AbstractThe International Height Reference System (IHRS), adopted by International Association of Geodesy (IAG) in its Resolution No. 1 at the XXVI General Assembly of the International Union of Geodesy and Geophysics (IUGG) in Prague in 2015, contains two novelties. Firstly, the mean-tide concept is adopted for handling the permanent tide. While many national height systems continue to apply the mean-tide concept, this was the first time that the IAG officially introduced it for a potential field quantity. Secondly, the reference level of the height system is defined by the equipotential surface where the geopotential has a conventional value W0 = 62,636,853.4 m2 s–2. This value was first determined empirically to provide a good approximation to the global mean sea level and then adopted as a reference value by convention. I analyse the tidal aspects of the reference level based on W0. By definition, W0 is independent of the tidal concept that was adopted for the equipotential surface, but for different concepts, different functions are involved in the W of the equation W = W0. I find that, in the empirical determination of the adopted estimate W0, the permanent tide is treated inconsistently. However, the consistent estimate from the same data rounds off to the same value. I discuss the tidal conventions and formulas for the International Height Reference Frame (IHRF) and the realisation of the IHRS. I propose a simplified definition of IHRF geopotential numbers that would make it possible to transform between the IHRF and zero-tide geopotential numbers using a simple datum-difference surface. Such a transformation would not be adequate if rigorous mean-tide formulas were imposed. The IHRF should adopt a conventional (best) estimate of the permanent tide-generating potential, such as that which is contained in the International Earth Rotation and Reference Systems Service Conventions, and use it as a basis for other conventional formulas. The tide-free coordinates of the International Terrestrial Reference Frame and tide-free Global Geopotential Models are central in the modelling of geopotential for the purposes of the IHRF. I present a set of correction formulas that can be used to move to the zero-tide model before, during, or after the processing, and finally to the mean-tide IHRF. To reduce the confusion around the multitude of tidal concepts, I propose that modelling should primarily be done using the zero-tide concept, with the mean-tide potential as an add-on. The widespread use of the expression “systems of permanent tide” may also have contributed to the confusion, as such “systems” do not have the properties that are generally associated with other “systems” in geodesy. Hence, this paper mostly uses “concept” instead of “system” when referring to the permanent tide.
The influence of the Earth’s magnetic field on strapdown inertial gravimetry using Q-Flex accelerometers: static and dynamic experiments
Authors: Johann Felix , Becker David , Becker Matthias , Hoss Matthias , Löwer Alexander , Förste Christoph 
Published: September 2021

AbstractIn recent strapdown airborne and shipborne gravimetry campaigns with servo accelerometers of the widely used Q-Flex type, results have been impaired by heading-dependent measurement errors. This paper shows that the effect is, in all likelihood, caused by the sensitivity of the Q-Flex type sensor to the Earth’s magnetic field. In order to assess the influence of magnetic fields on the utilised strapdown IMU of the type iMAR iNAV-RQH-1003, the IMU has been exposed to various magnetic fields of known directions and intensities in a 3-D Helmholtz coil. Based on the results, a calibration function for the vertical accelerometer is developed. At the example of five shipborne and airborne campaigns, it is outlined that under specific circumstances the precision of the gravimetry results can be strongly improved using the magnetic calibration approach: The non-adjusted RMSE at repeated lines decreased from 1.19 to 0.26 mGal at a shipborne campaign at Lake Müritz, Germany. To the knowledge of the authors, a significant influence of the Earth’s magnetic field on strapdown inertial gravimetry is demonstrated for the first time.
Systems of conductive skin for power transfer in clinical applications
Authors: Kourouklis Andreas P. , Kaemmel Julius , Wu Xi , Potapov Evgenij , Cesarovic Nikola , Ferrari Aldo , Starck Christoph , Falk Volkmar , Mazza Edoardo 
Published: September 2021

AbstractThe primary aim of this article is to review the clinical challenges related to the supply of power in implanted left ventricular assist devices (LVADs) by means of transcutaneous drivelines. In effect of that, we present the preventive measures and post-operative protocols that are regularly employed to address the leading problem of driveline infections. Due to the lack of reliable wireless solutions for power transfer in LVADs, the development of new driveline configurations remains at the forefront of different strategies that aim to power LVADs in a less destructive manner. To this end, skin damage and breach formation around transcutaneous LVAD drivelines represent key challenges before improving the current standard of care. For this reason, we assess recent strategies on the surface functionalization of LVAD drivelines, which aim to limit the incidence of driveline infection by directing the responses of the skin tissue. Moreover, we propose a class of power transfer systems that could leverage the ability of skin tissue to effectively heal short diameter wounds. In this direction, we employed a novel method to generate thin conductive wires of controllable surface topography with the potential to minimize skin disruption and eliminate the problem of driveline infections. Our initial results suggest the viability of the small diameter wires for the investigation of new power transfer systems for LVADs. Overall, this review uniquely compiles a diverse number of topics with the aim to instigate new research ventures on the design of power transfer systems for IMDs, and specifically LVADs.
Development and validation of a novel 3D-printed simulation model for open oesophageal atresia and tracheo-oesophageal fistula repair
Authors: Neville Jonathan J. , Chacon Carmen S. , Haghighi-Osgouei Reza , Houghton Natasha , Bello Fernando , Clarke Simon A. 
Published: September 2021

Abstract
Background
The role of simulation training in paediatric surgery is expanding as more simulation devices are designed and validated. We aimed to conduct a training needs assessment of UK paediatric surgical trainees to prioritise procedures for simulation, and to validate a novel 3D-printed simulation model for oesophageal atresia and tracheo-oesophageal fistula (OA-TOF) repair.

Methods
A questionnaire was sent to UK trainee paediatric surgeons surveying the availability and utility of simulation. The operation ranked as most useful to simulate was OA-TOF repair. 3D-printing techniques were used to build an OA-TOF model. Content, face and construct validity was assessed by 40 paediatric surgeons of varying experience.

Results
Thirty-four paediatric surgeons completed the survey; 79% had access to surgical simulation at least monthly, and 47% had access to paediatric-specific resources. Perceived utility of simulation was 4.1/5. Validation of open OA-TOF repair was conducted by 40 surgeons. Participants rated the model as useful 4.9/5. Anatomical realism was scored 4.2/5 and surgical realism 3.9/5. The model was able to discriminate between experienced and inexperienced surgeons.

Conclusion
UK paediatric surgeons voted OA-TOF repair as the most useful procedure to simulate. In response we have developed and validated an affordable 3D-printed simulation model for open OA-TOF repair.
Exploring the development of environmentally sustainable products through reward-based crowdfunding
Authors: Corsini Filippo , Frey Marco 
Published: September 2021

AbstractLiterature on crowdfunding is rapidly expanding by exploring typologies of crowdfunding projects, success factors of the projects, and how success factors might change depending on the project typologies. Firstly, based on the literature that suggests crowdfunding platforms provide a good alternative for financing innovative ideas, the present exploratory research aims to analyze how the crowdfunding instrument has been used in supporting the development of sustainable products. Secondly, based on researches that focus on success factors of crowdfunding campaigns, the present work aims to explore the success determinants of projects developing sustainable products. The results of the investigation show that the impact of crowdfunding in supporting the development and commercialization of sustainable products is quite marginal and only a few successful projects showed a high impact potential to contribute to the pathway to more sustainability by directing influencing incumbents. Moreover, through an in-depth examination of the campaigns aimed at developing sustainable products, we found that adopting just a generic keyword (i.e. sustainable, ecologic) to describe a sustainable product might weaken the success probability of the campaign. In light of the results achieved, the paper formulates some managerial suggestions illustrating how crowdfunding platforms could stimulate the collection of more environmentally friendly projects.
The spectrum of simplicial volume of non-compact manifolds
Authors: Heuer Nicolaus , Löh Clara 
Published: September 2021

AbstractWe show that, in dimension at least 4, the set of locally finite simplicial volumes of oriented connected open manifolds is $$[0,\infty ]$$

[
0
,
∞
]

. Moreover, we consider the case of tame open manifolds and some low-dimensional examples.
"These Questions Have Everything That Happens to me": Analysis of a Femicide Risk Assessment Tool for Abused Women in Brazil
Authors: Evans Dabney P. , Xavier Hall Casey D. , da Rocha Raiza Wallace Guimarães , Prado Sandra Marques , Signorelli Marcos C. 
Published: September 2021

AbstractPurposeThe purpose of this mixed-methods triangulation study was to assess the face validity and comprehension of a femicide risk assessment tool, the Danger Assessment-Brazil (DA-Brazil) among women seeking care in a one stop center for abused women in Curitiba, Brazil. Our secondary aim was to assess professionals' perceptions of feasibility for using the DA-Brazil in the same setting.MethodFifty-five women experiencing relationship violence completed the instrument and participated in cognitive interviews about their experience; professionals attending survivors were also interviewed.ResultsThe vast majority of women described the DA-Brazil instrument as being easy to comprehend (n = 41, 73.2%). Nearly half of participants (n = 26, 46.4%) had some kind of question regarding the DA-Brazil calendar, a tool to visualize abuse frequency and severity. Queries aligned with five categories: recollection of dates, scale, relationship status, terminology, and discomfort. Professionals reported that the DA-Brazil instrument would support referral decision-making.ConclusionThe overall face validity and comprehension of the DA-Brazil appears to be high. The majority of challenges were around the calendar activity. Professional perceptions of the DA-Brazil suggest a high degree of feasibility for its use in Brazilian healthcare settings. In order for the DA-Brazil to effectively be administered with facilitated support there is a need for training on the best use of the instrument. Accurate assessment of femicide risk is critical in a country like Brazil with high rates of femicide. The DA-Brazil provides a valid assessment of femicide risk and has the potential to trigger early intervention for those at risk.
ResGCN: attention-based deep residual modeling for anomaly detection on attributed networks
Authors: Pei Yulong , Huang Tianjin , van Ipenburg Werner , Pechenizkiy Mykola 
Published: September 2021

AbstractEffectively detecting anomalous nodes in attributed networks is crucial for the success of many real-world applications such as fraud and intrusion detection. Existing approaches have difficulties with three major issues: sparsity and nonlinearity capturing, residual modeling, and network smoothing. We propose Residual Graph Convolutional Network (ResGCN), an attention-based deep residual modeling approach that can tackle these issues: modeling the attributed networks with GCN allows to capture the sparsity and nonlinearity, utilizing a deep neural network allows direct residual ing from the input, and a residual-based attention mechanism reduces the adverse effect from anomalous nodes and prevents over-smoothing. Extensive experiments on several real-world attributed networks demonstrate the effectiveness of ResGCN in detecting anomalies.
Two Dimensions of Opacity and the Deep Learning Predicament
Authors: Boge Florian J. 
Published: September 2021

AbstractDeep neural networks (DNNs) have become increasingly successful in applications from biology to cosmology to social science. Trained DNNs, moreover, correspond to models that ideally allow the prediction of new phenomena. Building in part on the literature on ‘eXplainable AI’ (XAI), I here argue that these models are instrumental in a sense that makes them non-explanatory, and that their automated generation is opaque in a unique way. This combination implies the possibility of an unprecedented gap between discovery and explanation: When unsupervised models are successfully used in exploratory contexts, scientists face a whole new challenge in forming the concepts required for understanding underlying mechanisms.
Embodied higher cognition: insights from Merleau-Ponty’s interpretation of motor intentionality
Authors: Halák Jan 
Published: September 2021

AbstractThis paper clarifies Merleau-Ponty’s original account of “higher-order” cognition as fundamentally embodied and enacted. Merleau-Ponty’s philosophy inspired theories that deemphasize overlaps between conceptual knowledge and motor intentionality or, on the contrary, focus exclusively on abstract thought. In contrast, this paper explores the link between Merleau-Ponty’s account of motor intentionality and his interpretations of our capacity to understand and interact productively with cultural symbolic systems. I develop my interpretation based on Merleau-Ponty’s analysis of two neuropathological modifications of motor intentionality, the case of the brain-injured war veteran Schneider, and a neurological disorder known as Gerstmann’s syndrome. Building on my analysis of Schneider’s sensorimotor compensatory performances in relation to his limitations in the domains of algebra, geometry, and language usage, I demonstrate a strong continuity between the sense of embodiment and enaction at all these levels. Based on Merleau-Ponty’s interpretations, I argue that “higher-order” cognition is impaired in Schneider insofar as his injury limits his sensorimotor capacity to dynamically produce comparatively more complex differentiations of any given phenomenal structure. I then show how Merleau-Ponty develops and specifies his interpretation of Schneider’s intellectual difficulties in relation to the ambiguous role of the body, and in particular the hand, in Gerstmann’s syndrome. I explain how Merleau-Ponty defends the idea that sensorimotor and quasi-representational cognition are mutually irreducible, while maintaining that symbol-based cognition is a fundamentally enactive and embodied process.
Insights Into Genetics and Pathophysiology of Arrhythmogenic Cardiomyopathy
Authors: Gerull Brenda , Brodehl Andreas 
Published: September 2021

Abstract
Purpose of Review
Arrhythmogenic cardiomyopathy (ACM) is a genetic disease characterized by life-threatening ventricular arrhythmias and sudden cardiac death (SCD) in apparently healthy young adults. Mutations in genes encoding for cellular junctions can be found in about half of the patients. However, disease onset and severity, risk of arrhythmias, and outcome are highly variable and drug-targeted treatment is currently unavailable.

Recent Findings
This review focuses on advances in clinical risk stratification, genetic etiology, and pathophysiological concepts. The desmosome is the central part of the disease, but other intercalated disc and associated structural proteins not only broaden the genetic spectrum but also provide novel molecular and cellular insights into the pathogenesis of ACM. Signaling pathways and the role of inflammation will be discussed and targets for novel therapeutic approaches outlined.

Summary
Genetic discoveries and experimental-driven preclinical research contributed significantly to the understanding of ACM towards mutation- and pathway-specific personalized medicine.
Modeling the outcome of supernova explosions in binary population synthesis using the stellar compactness
Authors: Dabrowny Maciej , Giacobbo Nicola , Gerosa Davide 
Published: September 2021

AbstractFollowing the collapse of their cores, some of the massive binary stars that populate our Universe are expected to form merging binaries composed of black holes and neutron stars. Gravitational-wave observations of the resulting compact binaries can reveal precious details on the inner workings of the supernova mechanism and the subsequent formation of compact objects. Within the framework of the population-synthesis code mobse, we present the implementation of a new supernova model that relies on the compactness of the collapsing star. The model has two free parameters, namely the compactness threshold that separates the formation of black holes and that of neutron stars, and the fraction of the envelope that falls back onto the newly formed black holes. We compare this model extensively against other prescriptions that are commonly used in binary population synthesis. We find that the cleanest signatures of the role of the pre-supernova stellar compactness are (1) the relative formation rates of the different kinds of compact binaries, which mainly depend on the compactness threshold parameter, and (2) the location of the upper edge of the mass gap between the lightest black holes and the heaviest neutron stars, which mainly depends on the fallback fraction.
Selective and self-validating breath-level detection of hydrogen sulfide in humid air by gold nanoparticle-functionalized nanotube arrays
Authors: Panes-Ruiz Luis Antonio , Riemenschneider Leif , Al Chawa Mohamad Moner , Löffler Markus , Rellinghaus Bernd , Tetzlaff Ronald , Bezugly Viktor , Ibarlucea Bergoi , Cuniberti Gianaurelio 
Published: September 2021

AbstractWe demonstrate the selective detection of hydrogen sulfide at breath concentration levels under humid airflow, using a self-validating 64-channel sensor array based on semiconducting single-walled carbon nanotubes (sc-SWCNTs). The reproducible sensor fabrication process is based on a multiplexed and controlled dielectrophoretic deposition of sc-SWCNTs. The sensing area is functionalized with gold nanoparticles to address the detection at room temperature by exploiting the affinity between gold and sulfur atoms of the gas. Sensing devices functionalized with an optimized distribution of nanoparticles show a sensitivity of 0.122%/part per billion (ppb) and a calculated limit of detection (LOD) of 3 ppb. Beyond the self-validation, our sensors show increased stability and higher response levels compared to some commercially available electrochemical sensors. The cross-sensitivity to breath gases NH3 and NO is addressed demonstrating the high selectivity to H2S. Finally, mathematical models of sensors’ electrical characteristics and sensing responses are developed to enhance the differentiation capabilities of the platform to be used in breath analysis applications.
A statistical DEM approach for modelling heterogeneous brittle materials
Authors: Wessling Albin , Larsson Simon , Jonsén Pär , Kajberg Jörgen 
Published: September 2021

AbstractBy utilizing numerical models and simulation, insights about the fracture process of brittle heterogeneous materials can be gained without the need for expensive, difficult, or even impossible, experiments. Brittle and heterogeneous materials like rocks usually exhibit a large spread of experimental data and there is a need for a stochastic model that can mimic this behaviour. In this work, a new numerical approach, based on the Bonded Discrete Element Method, for modelling of heterogeneous brittle materials is proposed and evaluated. The material properties are introduced into the model via two main inputs. Firstly, the grains are constructed as ellipsoidal subsets of spherical discrete elements. The sizes and shapes of these ellipsoidal subsets are randomized, which introduces a grain shape heterogeneity Secondly, the micromechanical parameters of the constituent particles of the grains are given by the Weibull distribution. The model was applied to the Brazilian Disc Test, where the crack initiation, propagation, coalescence and branching could be investigated for different sets of grain cement strengths and sample heterogeneities. The crack initiation and propagation was found to be highly dependent on the level of heterogeneity and cement strength. Specifically, the amount of cracks initiating from the loading contact was found to be more prevalent for cases with higher cement strength and lower heterogeneity, while a more severe zigzag shaped crack pattern was found for the cases with lower cement strength and higher heterogeneity. Generally, the proposed model was found to be able to capture typical phenomena associated with brittle heterogeneous materials, e.g. the unpredictability of the strength in tension and crack properties.
Adiposità dell’osso e fragilità scheletrica
Authors: Cipriani Cristiana 
Published: September 2021

SommarioNell’ambito del reciproco cross-talk tra metabolismo osseo e tessuto adiposo, lo studio del tessuto adiposo midollare (BMAT) è uno degli spunti di ricerca più interessanti degli ultimi anni. Un aumento del BMAT è descritto in diverse condizioni cliniche, in cui vi è una correlazione inversa tra BMAT, densità minerale ossea e qualità dell’osso. Nella presente rassegna vengono riassunti i dati sperimentali e clinici più recenti circa l’interrelazione tra danno scheletrico e aumento del BMAT.
Towards Green 3D-Microfabrication of Bio-MEMS Devices Using ADEX Dry Film Photoresists
Authors: Roos Michael M. , Winkler Andreas , Nilsen Madeleine , Menzel Siegfried B. , Strehle Steffen 
Published: September 2021

AbstractCurrent trends in miniaturized diagnostics indicate an increasing demand for large quantities of mobile devices for health monitoring and point-of-care diagnostics. This comes along with a need for rapid but preferably also green microfabrication. Dry film photoresists (DFPs) promise low-cost and greener microfabrication and can partly or fully replace conventional silicon-technologies being associated with high-energy demands and the intense use of toxic and climate-active chemicals. Due to their mechanical stability and superior film thickness homogeneity, DFPs outperform conventional spin-on photoresists, such as SU-8, especially when three-dimensional architectures are required for micro-analytical devices (e.g. microfluidics). In this study, we utilize the commercial epoxy-based DFP ADEX to demonstrate various application scenarios ranging from the direct modification of microcantilever beams via the assembly of microfluidic channels to lamination-free patterning of DFPs, which employs the DFP directly as a substrate material. Finally, kinked, bottom-up grown silicon nanowires were integrated in this manner as prospective ion-sensitive field-effect transistors in a bio-probe architecture directly on ADEX substrates. Hence, we have developed the required set of microfabrication protocols for such an assembly comprising metal thin film deposition, direct burn-in of lithography alignment markers, and polymer patterning on top of the DFP.