bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recruitment of a Long-term-memory Supporting System During Repeated Maintenance of an Abstract Visual Image in Working Memory: An EEG Study
Authors: Heinen Klaartje T.H. , Kenemans J. Leon , Stigchel Stefan Van der 
Published: June 2021

Abstract
Humans can flexibly transfer information between different memory systems. Information in visual working memory (VWM) can for instance be stored in long-term memory (LTM) when a scene is repeatedly memorized. Conversely, information can be retrieved from LTM and temporarily held in WM when needed. It has previously been suggested that a neural transition from parietal- to midfrontal activity reflects transfer of information from WM to LTM during repeated visual search for the same single item. However, whether these observed neural changes truly represent consolidation and are also observed when memorizing and (explicitly) recollecting a rich visual scene (rather than a single target), remains unclear. The current EEG study investigates whether such a gradual shift in memory-correlates is also observed when an abstract colour-array is repeatedly memorized and explicitly recollected in a WM paradigm. Importantly, we tested the functional significance of a neural shift for longer-term consolidation in a subsequent recognition task. Our results provide supporting evidence for recruitment of an LTM-supporting storage system during WM, which facilitates visual WM maintenance and is indexed by (sustained) modulation of a midfrontal component. Enhanced explicit memory recollection during WM is associated with- and possibly facilitated by an emerging late contralateral parietal activity.
Surface Functionalization of Cotton Fabric with Ag3PO4 via Citric Acid Cross-linking Using An Industrialized Padding Process and Its Self-Cleaning Performance
Authors: Yan Yingwen , Dong Yongchun , Bian Liran 
Published: June 2021

Abstract
Cotton fabric was first modified with citric acid to introduce surface carboxyl groups, which then coordinated with Ag+ ions to prepare the Ag3PO4 finished cotton fabric through further reacting with PO43- ions using an industrialized pad-dry-cure process. Increasing surface carboxyl groups could significantly enhanced the loaded content of Ag3PO4. The padding process could more strongly fix Ag3PO4 on fabric than the conventional dipping method. The Ag3PO4 finished cotton fabric showed higher photocatalytic capacity than pure Ag3PO4 particles owing to the synergetic effect of the Ag complex with the carboxyl groups on the fabric. Moreover, the treatment of KBr and fixing agent further improved the the stability and anti-photocorrosion performance of the samples. Importantly, the finished fabric also exhibited better self-cleaning performance for Reactive Red 195 as a model stain under varied irradiation. The dye was found to be decomposed and mineralized on the finished fabric under artificial or solar irradiation.
3D Models of Alzheimer’s Disease Patient Microglia Recapitulate Disease Phenotype and Show Differential Drug Responses Compared to 2D
Authors: Cuni-Lopez Carla , Quek Hazel , Oikari Lotta , Stewart Romal , Nguyen Tam Hong , Sun Yifan , Guo Christine , Lupton Michelle , White Anthony Robert 
Published: June 2021

Abstract
Background: Alzheimer’s disease (AD) is an increasingly prevalent disorder with no cure due to unsuccessful therapeutic targets. An attractive alternative target is neuroinflammation, which mediates neurodegeneration, and is primarily driven by microglia, the brain’s immune cells. To evaluate if targeting microglia could improve drug success rates in AD, we need in vitro model systems that faithfully recapitulate patient-specific microglial characteristics. Methods: We developed novel 3D models of monocyte-derived microglia-like cells (MDMi) from AD patients.Results: MDMi in 3D exhibited mature microglial features, including a highly branched morphology and enhanced bonafide microglial marker expression compared to 2D. AD MDMi in 3D co-cultures with neuro-glial cells showed alterations in cell-to-cell interactions, growth factor and cytokine secretion and responses to amyloid-β. Drug screening in 3D AD MDMi revealed different cytokine responses compared to 2D.Conclusion: 3D MDMi models show disease- and drug-specific responses that are not apparent in 2D and provide platforms for more effective and personalised drug testing.
What Are the Effective Health Literacy Skills in Adopting Walking Behavior to Prevent Osteoporosis?
Authors: Panahi Rahman , Amjadian Mohiadin , siboni Fatemeh Samiei , Shafaei Mahya , kazemi Seyedeh somayeh , Dehghankar Leila 
Published: June 2021

Abstract
Background:Considering the effect of exercise and health literacy in preventing osteoporosis, the effect of health literacy in adopting preventive behaviors, and the role of health volunteers in transferring the health messages to the community, this study aimed to determine the relationship between health literacy skills and adopting walking behavior to prevent osteoporosis in health volunteers. Methods:In a descriptive cross-sectional study, 290 health volunteers referring to Qazvin health centers in 1399 were selected through Multi-stage random sampling. Data were collected using a health literacy questionnaire (HELIA) and a questionnaire for the adoption of walking behaviors for the prevention of osteoporosis, and they were analyzed using descriptive statistics and logistic regression in SPSS software version 23. Results: The mean and standard deviation of the adoption of walking behaviors were 10.57 ± 1.43which was moderate. Age (P = 0.025, 1/098), decision-making skills and application of health information (P <0.001), perception (P = 0.037, 054/1 = OR) and evaluation (P = 0.029, 049 = OR) were factors affecting the adoption of this behavior, so that by increasing one score to these variables, the chance of adopting the behavior increased 135/1, 1.054 and 049/1 respectively. Also, the level of education was another effective factor in adopting this behavior, so that having a favorable level of adoption of this behavior in health volunteers with diploma degree (P = 0.017, OR = 0.736) and below diploma (011/0 = P, 960 = OR), were 0.736 and 0.960 times of those with university degrees respectively.Conclusion:To improve the adoption of walking behaviors to prevent osteoporosis, we should pay special attention to effective health literacy skills in the health volunteers.
Association of Mesothelioma Deaths With Cumulated Neighborhood Exposures Due to a Large-Scale Asbestos Cement Plant in Amagasaki City, Japan: A Nested Case-control Study
Authors: Kitamura Yuri , Zha Ling , Liu Rong , Shima Masayuki , Nakaya Tomoki , Kurumatani Norio , Kumagai Shinji , Goji Junko , Sobue Tomotaka 
Published: June 2021

Abstract
BackgroundAlthough a causal relationship between mesothelioma and asbestos exposure is well known, few studies have shown a relationship to non-occupational exposure, including neighborhood exposure, most likely because of the large effect size of occupational exposure. The aim of this study was to quantify the risk of malignant mesothelioma death associated with neighborhood asbestos exposure due to a large-scale asbestos-cement (AC) plant in Amagasaki, Japan, by properly adjusting for occupational exposure. MethodsThis was a nested case-control study in which a fixed population of 143,929 residents who had been living in Amagasaki City between 1975 and 2002 were followed from 2002 to 2015. All 133 cases and 403 matched controls were interviewed about their occupational, domestic, household, and neighborhood asbestos exposures. Odds ratios (ORs) for mesothelioma death associated with neighborhood exposure were estimated by a conditional logistic-regression model that adjusted for other asbestos exposures. We adopted cumulative indices that considered residence-specific asbestos (crocidolite) concentrations and durations during the potential exposure period of 1957-1975 to evaluate individual neighborhood exposures.ResultsThere was an increasing, dose-dependent risk of mesothelioma death associated with neighborhood exposure, demonstrated by ORs in the highest quintile category that were 21.4 (95%CI: 5.8 to 79.2) for all, 23.7 (95% CI: 3.8-147.2) for males and 26.0 (95% CI: 2.8-237.5) for females, compared to the lowest quintile, respectively. These results clearly demonstrated no substantial differences between males and females in relation to the magnitude of risk from neighborhood exposure.Our findings suggest that the risk of mesothelioma death associated with neighborhood exposure persists and will not be diminished for many years, even though it has been decades since the AC plant closed. ConclusionsBy adjusting for occupational and other asbestos exposures, a dose-dependent relationship was demonstrated between mesothelioma death and neighborhood asbestos exposure from a large-scale AC plant.
Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P2 by a phosphotransferase
Authors: Walpole Glenn , Pacheco Jonathan , Chauhan Neha , Abbas Yazan , Montaño-Rendón Fernando , Liu Zetao , Zhu Hongxian , Brumell John , Deiters Alexander , Hammond Gerald (R.V.) , Grinstein Sergio , Fairn Gregory 
Published: June 2021

Abstract
Despite their comparatively low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P3 and PtdIns(3,4)P2 are uniquely important, as they promote cell growth, survival, and migration. Pathogenic organisms have developed means to subvert phosphoinositide metabolism to promote successful infection and their survival within host organisms. We demonstrate that PtdIns(3,4)P2 is generated in host cells by effectors of the enteropathogenic bacteria Salmonella and Shigella. Pharmacological, gene silencing and heterologous expression experiments revealed that, remarkably, the biosynthesis of PtdIns(3,4)P2 occurs independently of phosphoinositide 3-kinases. Instead, we found that the Salmonella effector SopB, heretofore believed to be a phosphatase, generates PtdIns(3,4)P2 de novo via a phosphotransferase/phosphoisomerase mechanism. Recombinant SopB is capable of generating PtdIns(3,4)P2 from PtdIns(4,5)P2 in a cell-free system. Through a remarkable instance of convergent evolution, bacterial effectors acquired the ability to synthesize 3-phosphorylated phosphoinositides by an ATP- and kinase-independent mechanism, thereby subverting host signaling to gain entry and even provoke oncogenic transformation.
New measurement method corrected a failure in
special relativity
Authors: Schatz Viktor 
Published: June 2021

Abstract
A logical reasoning problem in the Special Relativity interpretation of the Lorentz transformation was discovered and corrected by introducing an alternative interpretation of Lorentz transformations with a relativistic measuring process based on both, stretched time and length units, whereby the measurements as a consequence measure a shortened distance and time lines as variables due to used units. The space shuttles are getting longer instead of shorter and a barn-pole paradox does not occur. The spatial locations remain in their locations and space is not contracted and not changed. The failure is that by contracting both units and distance the Lorentz factor is eliminated and relativity was vanished. The elementary particles have their own measuring devices for time and length in the form of wavelengths and frequencies and they read distances and durations of different lengths from space using their own relativistically different units. The new interpretation is covered by the two postulates of Einstein. This is a sensational result too in view of all dramatic and romantic history as there is really a failure discovered. The Lorentz transformations remain being in use with another method. The new theory and the discovered problems of logical failures are explained vividly in the same manner as Special Relativity was using easy be thought samples. Reader do not need a high level of mathematics to be fit for as it is a more qualitatively thematic for every one who is interested in relativity matters.
Soil macrofauna abundance, biomass and selected soil properties in the home garden and coffee-based agroforestry systems at Wondo Genet, Ethiopia
Authors: Asfaw Asaye , Zewudie Solomon 
Published: June 2021

Abstract
BackgroundIn Ethiopia, the majority of farmers have limited access to inorganic fertilizers, but agricultural development is largely limited by economic constraints. Agroforestry practices (AFPs) are the typical solutions for such kind of agricultural systems. AFPs play critical roles in the improvement of abundance and biomass of soil invertebrates, which are necessary for long-term improvement of soil properties. The overall objective of the present study was to investigate the spatial and temporal dynamics in macro fauna abundance and biomass in home garden and coffee- based agroforestry systems and to relate it with the dynamics in a range of soil physico-chemical parameters.Result The two AF systems did differ in plant species richness and diversity of life forms. For both sampling seasons, higher number of macrofauna was collected from home garden AF than Coffee-based AF plot. Total macrofaunal biomass between the wet and dry season was significant (p <0.05) for samples from home garden AF plot. Depth-wise pattern in macrofauna abundance and biomass showed distinct seasonal variation in the two-agroforestry systems. For both AF plots, marked and significant (p<0.001) seasonal differences were observed in relation to soil moisture, temperature, and pH. On the other hand, dry season samples from home garden AF plot had significantly (p<0.001) higher moisture content and soil pH than coffee-based AF plot.Conclusion The abundance and biomass of soil macrofauna including soil properties were improved by AFs. Thus, the results of this study encourage farmers and policy makers about land administration to implement AFs to ensure sustainability of soil fertility for sustainable production and productivity.
Urodynamic changes in women subjected to gynecological surgeries
Authors: de Melo Luiz Henrique Simões 
Published: June 2021

Abstract
Introduction: Disorders inherent to aging are increasingly present, with voiding dysfunctions and greater submission to surgeries among them. Objective: To analyze the influence of gynecological surgeries (Hysterectomy-HT and Colpoperineoplasty-CPP) on urodynamic bladder function parameters of adult women. Methods: A comparative study of urodynamic data from 706 patients was performed at the Urology Service of HC/UFPE. Previously, patients with any known clinical factor which could affect bladder function were excluded. These patients were analyzed in groups according to their history of gynecological surgery and age group (Non-elderly/elderly). The control group was composed by women without any gynecological surgery history. Results: All urodynamic parameters were worse in the elderly subgroup. The fundamental difference between the groups consisted of senility and past gynecological surgeries (higher in the elderly group). In the general female population, a history of gynecological surgeries was related to several alterations in urodynamic parameters. All urodynamic micturition phase parameters were significantly worse in patients with colpoplasty history. Hysterectomy history was also associated to a deterioration in some micturition parameters. However, no relationship between gynecological surgeries and urodynamic changes was found in the elderly women subgroup. Conclusion: Gynecological surgeries (HT/CPP) do not alter the prevalence and/or intensity of voiding dysfunctions already expected in the older age group of women from the aging process itself. Functional changes in the lower urinary tract resulting from aging are imposed in elderly women, regardless of their gynecological surgery history.
«New dispersion formula and results of its application»
Authors: Chernov Andrey 
Published: June 2021

Abstract
The aim of the study was to obtain a new physical formula for determining the refractive indices of light as a function of wavelength, which can be applied to a wide range of transparent substances. In the process of research on the basis of Einstein's relativistic formula, such a dispersion formula was obtained. Comparison of the obtained indicators with laboratory indicators showed the high accuracy of the new dispersion formula, which was ±10 -7-10 -5 in the calculated wavelength ranges of more than 100 nm. The new dispersion formula is obtained on the basis of the mathematical dependence of the speed of propagation of photons in a transparent substance on the energy density of electron clouds of atoms of the substance. Energy is a universal category, therefore, it is possible to apply the basic version of the new formula (where instead of the wavelength there is the energy density of electron clouds) when conducting research in all areas of light generation, manipulation and detection. And, finally, the very fact of applying the adapted relativistic Einstein's formula to physical processes occurring at the atomic level allows us to look at the nature of the interaction of light and matter from a new angle.
The non-canonical mechanism of ER stress-mediated progression of prostate cancer
Authors: Pachikov Artem N , Gough Ryan R , Christy Caroline , Morris Mary , Casey Carol , LaGrange Chad , Bhat Ganapati , Kubyshkin Anatoly , Fomochkina Irina , Zyablitskaya Evgeniya , Makalish Tatiana , Golubinskaya Elena , Eremenko Sergey , Riethoven Jean-Jack , Maroli Amith , Payne Thomas , Powers Robert , Lushnikov Alexander , Macke Amanda , Petrosyan Armen 
Published: June 2021

Abstract
Background The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and the link between alcoholism and progression of prostate cancer (PCa) is well documented but not well characterized. According to the canonical model, the mediator of ER stress, ATF6, is cleaved sequentially in the Golgi by S1P and S2P proteases; thereafter, the genes responsible for unfolded protein response (UPR) undergo transactivation. Methods Cell lines used were non-malignant prostate epithelial RWPE-1 cells, androgen-responsive LNCaP and 22RV1 cells, as wells as androgen-refractory PC-3 cells. We also utilized PCa tissue sections from patients with different Gleason scores and alcohol consumption backgrounds from different. Several sophisticated approaches were employed, including Structured illumination superresolution microscopy, Proximity ligation assay, Atomic force microscopy, and Nuclear magnetic resonance spectroscopy. Results Herein, we identified the trans-Golgi matrix dimeric protein GCC185 as a Golgi retention partner for both S1P and S2P, and in cells lacking GCC185, these enzymes lose intra-Golgi situation. Progression of prostate cancer (PCa) is associated with overproduction of S1P and S2P but monomerization of GCC185 and its downregulation. Utilizing different ER stress models, including ethanol administration, we found that PCa cells employ an elegant mechanism that auto-activates ER stress by fragmentation of Golgi, translocation of S1P and S2P from Golgi to ER, followed by intra-ER cleavage of ATF6, accelerated UPR, and cell proliferation. The segregation of S1P and S2P from Golgi and activation of ATF6 are positively correlated with androgen receptor signaling, different disease stages, and alcohol consumption. Finally, depletion of ATF6 significantly retarded the growth of xenograft prostate tumors and blocks production of pro-metastatic metabolites. Conclusions We found that progression of PCa associates with translocation of S1P and S2P proteases to the ER and subsequent ATF6 cleavage. This obviates the need for ATF6 transport to the Golgi and enhances UPR and cell proliferation. Thus, we provide the novel mechanistic model of ATF6 activation and ER stress implication in the progression of PCa, suggesting ATF6 is a novel promising target for prostate cancer therapy.
Situational Analysis of the impact of COVID-19 pandemic on digital health research initiatives in South Asia
Authors: Prabhune Akash Gajanan , Mallawaram Aishwarya , Bhat Sachin , Shagufta Ayesha Mehar 
Published: June 2021

Abstract
The objective of this paper was to evaluate and compare the quantity, and sustainability of digital health initiatives in the South Asia region pre-pandemic and during the COVID-19 pandemic. The study used a two-step methodology of a) Descriptive analysis of digital health research articles published from 2016-21 from South Asia in terms of stratification of research articles based on diseases and conditions they were developed, geography, tasks wherein the initiative was applied. b) A simple and replicable tool was developed by authors to assess the sustainability of digital health initiatives using Experimental or Observational study designs. The results from descriptive analysis highlight; a) 40% increase in the number of studies report in 2020 when compared to 2019, b) The three most common diseases and conditions wherein substantive digital health research has been focused are Health Systems Strengthening, Ophthalmic Disorders, and COVID-19, c) Remote Consultation, Health Information delivery and Clinical Decision support systems are the top three commonly developed tools. We developed and estimated the inter-rater operability of the sustainability assessment tool was ascertained with a Kappa value of 0.806 (± 0.088). We conclude that the COVID-19 pandemic had a positive impact on digital health research with improvement in the number of digital health initiatives and improvement in sustainability score of studies published during COVID-19.
Estimating Social Contacts in Mass Gatherings Through Agent-Based Simulation Modeling: Case of Hajj Pilgrimage
Authors: Tofighi Mohammadali , Asgary Ali , Tofighi Ghassem , Najafabadi Mahdi , Arino Julian , Amiche Amine , Rahman Ashrafur , McCarthy Zachary , Bragazzi Nicola , Thommes Edward , Coudeville Laurent , Ghassemi Abbas , Bourouiba Lydia , Wu Jianhong 
Published: June 2021

Abstract
Most mass gathering events have been suspended due to the SARS-CoV-2 pandemic. However, with vaccination rollout, whether and how to organize some of these mass gathering events arises as part of the pandemic recovery discussions, and this calls for decision support tools. Hajj, one of the world's largest religious gatherings, was substantively scaled down in 2020 and it is still unclear if it will take place in 2021 and subsequent years. Considering the disease trends and vaccination conditions in the pilgrims’ country of origin, and the operational and logistical aspects of implementing public health measures, Hajj reopening conditions could be very complex. Simulating disease transmission dynamics during the Hajj season under different conditions can provide some insights for better decision-making. Since most dis-ease risk assessment models require data on the number and nature of possible close contacts between individuals, we seek to use integrated agent-based modeling and discrete events simulation techniques to capture risky contacts among the pilgrims in one of the Hajj major sites, namely Masjid-Al-Haram. In particular, we assessed different scenarios concerning the total number of pilgrims and enforced physical distancing measures. Our simulation results show that a plethora of risky contacts may occur during the rituals. Also, as the total number of pilgrims increases at each site, the number of risky contacts increases, and physical distancing measures may be challenging to maintain beyond a certain number of pilgrims in the site.