bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the learning divide: the role of institutional WOM in stimulating emerging countries’ SMEs internationalization
Authors: Aliedan Meqbel 
Published: May 2021

PurposeThe purpose of this study is to explore the relationship between experiential knowledge of foreign markets, institutional word of mouth (WOM) and small and medium enterprises’ (SMEs’) internationalization. Specifically, it aims to provide explanations of what and how cross-border experiential knowledge can be institutionally transmitted for SMEs’ internationalization purposes via WOM.Design/methodology/approachAn exploratory approach was adopted within the phenomenological/qualitative research tradition. The data collection process was conducted through 23 semi-structured interviews with founders and chief executive officers of Saudi international SMEs.FindingsThe study’s findings confirm that SMEs seeking productive opportunities in the international market could improve their internationalization experience if they made proper use of institutional WOM as a catalyst for inter-firm learning. This concerns SMEs from emerging countries in particular as they are usually in a bid to legitimatize their presence in foreign markets.Originality/valueThe triadic relationship between experiential knowledge, institutional WOM and internationalization has not been previously researched. The current study, therefore, clearly adds value to the concept of WOM from three dimensions: institutionalization, cross-borderity and SMEs’ internationalization.
Tourism in the post COVID-19 era: evidence from hotels in the North East of England
Authors: Spanaki Maria Zoi , Papatheodorou Andreas , Pappas Nikolaos 
Published: May 2021

Purpose
This paper aims to examine developments in tourism during the COVID-19 pandemic using the hotel sector in the North-East of England as the area of study. The country has attracted a lot of attention not only because of its importance as a tourism destination but also due to its rather controversial management of the pandemic at least in its early stages.

Design/methodology/approach
Fifteen semi-structured interviews based on ten open-ended questions were conducted with North East of England-based hotel managers of international brands on the level of their hotels’ preparedness to effectively deal with pandemic cases. The interviews took place in August and September 2020 with participants kept anonymous.

Findings
Meeting new operational and bureaucratic requirements added to the cost structure and proved a major challenge for managers who saw their hotel occupancy rates and revenue collapsing within a short period of time. Innovative and aggressive pricing strategies were introduced to lure especially younger travelers in the absence of business clientele. Staff were made redundant and/or asked to work overtime making effective human resource management very difficult.

Originality/value
This is one of the first research attempts to highlight the importance of the COVID-19 pandemic for the hotel sector in a major region of the UK. The paper also attempts some generalization by discussing managerial implications and suggesting a possible way forward for the hotel sector. Developing resilience by building on previously used successful business practices proves of essence.
Disaster management in Indonesian tourist destinations: how institutional roles and community resilience are mediated
Authors: Rahmafitria Fitri , Sukmayadi Vidi , Suryadi Karim , Rosyidie Arief 
Published: May 2021

PurposeThis paper attempts to evaluate the current collaborative model of disaster management initiated by the Indonesian Government at the regional level. The paper aims at providing recommendations for a more functional model of local communities' resilience by promoting the synergy of roles among the community, industry and local government.Design/methodology/approachTo achieve the study objective, the authors conducted the qualitative approach. The study used The Hyogo Framework to Action (HFA) 2000–2015 disaster management approach. The HFA approach contains substances of disaster management guidelines on social, economic and environmental aspects, as well as the strategies for implementing the guidelines.FindingsThe study's findings have indicated that substandard institutions can hamper collaborative processes and lower the level of community resilience. A collaborative model can appropriately operate when the formal institution plays its role as the central coordinator and ensures that transparency, decision-making and representation are met. Furthermore, the community and formal educational institutions are essentials as the foundation of building community resilience.Practical implicationsThis study was limited to a case study in an Indonesian popular tourist destination. Hence, it could be extended by conducting comparative studies with other destinations in developing countries to explore their disaster management and the government involvement in each respective countries.Social implicationsThis study was limited to a case study in an Indonesian popular tourist destination. Hence, it could be extended by conducting comparative studies with other destinations in developing countries to explore their disaster management and government involvement in each respective country.Originality/valueIn this paper, the authors propose a novel approach to improve the current disaster management model. The proposed approach focuses on designing an institutional model for tourism destinations' disaster management, where the stakeholders are less-functional in working collaboratively. The study findings suggest that educational institutions and disaster communities must take the mediator role in bridging knowledge transfer among the government, the community and the tourism industry.
The Israeli travel and tourism industry faces COVID-19: developing guidelines for facilitating and maintaining a nuanced response and recovery to the pandemic
Authors: Schmidt Joshua , Altshuler Alex 
Published: May 2021

Purpose
This paper aims to discuss how the tourism industry is contending with the economic and interorganizational challenges wrought by the COVID-19 outbreak and heightened by a lack of communication between the government and local businesses in the state of Israel. The researchers examine the dependency of the tourism industry on the general preparation programs that were developed and are currently being deployed by the relevant national stakeholders and question whether instead, it should use the pandemic as a catalyst for formulating its own nuanced tourism-travel-and-hospitality-oriented strategies and procedures.

Design/methodology/approach
Applying an ethnographic-based mix-methods research approach, this paper draws on insights from data compiled by fusing existing theoretical and emerging practical knowledge with empirical research (qualitative and quantitative) conducted among numerous relevant macro (governmental/centralized industry) and micro (hotels, travel and tourism operators and service providers) stakeholders as well as potential consumers.

Findings
It is essential that national and local government bodies form collaborative interorganizational relationships with local stakeholders to jointly activate case-specific hospitality and travel-specific risk mitigation management strategies. Moreover, the pandemic laid bare the tentative and fragile nature of the globalized tourism industry supply and demand chains, a condition that may be remedied via a pivot toward using national or even regional supply chains and goods and service providers. Within Israel, such changes could lead to increased economic benefits that extend beyond the tourism industry to provide certain security-related benefits.

Originality/value
Relating to idiosyncratic factors relevant to an Israeli cultural context, this paper uses the ethnographic field-borne familiarity of the researchers with the tourism and travel industries in Eilat and the Dead Sea to offer applicable suggestions for leveraging certain industry resources to both meet the demands of the present-day circumstances and cultivate a multifaceted organizational web of macro and micro social, economic and environmental networks so as to foster a more diversified and therefore resilient local tourism and travel economy.
Symptomatic improvement after mesh removal: a prospective longitudinal study of women with urogynaecological mesh complications
Authors: Pace N , Artsen A , Baranski L , Palcsey S , Durst R , Meyn L , Moalli PA 
Published: May 2021

ObjectiveTo compare clinical characteristics and outcomes in patients undergoing excision of polypropylene urogynaecological mesh for pain, mesh exposure or both.DesignProspective, longitudinal cohort.SettingAcademic tertiary referral centre.PopulationWomen undergoing complete vaginal mesh excision for mesh exposure and/or pain.MethodsClinical and patient‐reported outcomes assessing pain (visual analog scale, VAS), bother (Pelvic Floor Distress Inventory, PFDI) and functional impact (Pelvic Functional Impact Questionnaire, PFIQ) were collected at baseline, 6, 12 and 24 months after complete mesh excision. Outcomes were compared by mesh type (sling, prolapse [transvaginal or sacrocolpopexy mesh], both) and complication (pain, exposure, both).Main outcome measures‘Much better’ or ‘Very much better’ on Patient Global Impression of Improvement (PGI‐I) up to 2 years after removal.ResultsOf 173 women, 48 underwent removal for pain, 27 for exposure and 98 for exposure plus pain. ‘Moderate to severe’ baseline symptoms were reported by 75%; the most prevalent and severe symptom was dyspareunia. Patients with pain alone were most bothered (PFDI median 234.2, interquartile range 83, P = 0.02) and had the highest functional impact (PFIQ median 181, interquartile range 138, P < 0.001). After excision, only 33.3% of women with pain alone reported ‘improved’ symptoms (PGI‐I), versus 73.9% with exposure, 58.3% with exposure plus pain (P = 0.03) with no differences in PGI‐I by mesh type. VAS scores decreased in all groups, but PFDI and PFIQ did not improve in pain patients.ConclusionsIn women experiencing a pain complication after urogynaecological mesh insertion, mesh removal often does not improve symptoms.Tweetable abstractOnly 33% of women with pain complications have improved symptoms after urogynaecological mesh removal.
Important research outcomes for treatment studies of perinatal depression: systematic overview and development of a core outcome set
Authors: Hellberg C , Österberg M , Jonsson AK , Fundell S , Trönnberg F , Jonsson M , Skalkidou A 
Published: May 2021

ObjectiveTo develop a Core Outcome Set (COS) for treatment of perinatal depression.DesignSystematic overview of outcomes reported in the literature and consensus development study.SettingInternational.PopulationTwo hundred and twenty‐two participants, mainly patients, healthcare professionals and researchers, representing 13 countries.MethodsA systematic overview of outcomes reported in recently published research, a two‐round Delphi survey and a consensus meeting at which the final COS was decided using modified nominal group technique.Main resultsIn the literature search, 1772 abstracts were identified and evaluated, and 165 studies were finally included in the review. In all, 106 outcomes were identified and included in the Delphi survey. In all, 222 participants registered for the first round of the Delphi survey and 151 (68%) responded. In the second round, 123 (55%) participants responded. Thirteen participants attended the consensus meeting, where the following nine outcomes were agreed upon for inclusion in the final COS: self‐assessed symptoms of depression, diagnosis of depression by a clinician, parent to infant bonding, self‐assessed symptoms of anxiety, quality of life, satisfaction with intervention, suicidal thoughts, attempted or committed suicide, thoughts of harming the baby, and adverse events.ConclusionsThe relevant stakeholders prioritised outcomes and reached consensus on a COS comprising nine outcomes. We expect that this COS will contribute to the consistency and uniformity of outcome selection and reporting in future clinical trials involving treatment of perinatal depression.Tweetable abstractDevelopment of a core outcome set regarding treatment for perinatal depression by @SBU_en.
Quantifying the rate of recurrence of postoperative Crohn's disease with biological therapy. A meta‐analysis
Authors: Jain Sneha R. , Ow Zachariah G. W. , Chin Yip H. , Lim Wen H. , Kong Gwyneth , Tham Hui Y. , Wong Neng W. , Chong Choon S. , Foo Fung J. , Chan Webber P. W. 
Published: May 2021

ObjectivePreventing the postoperative recurrence (POR) of Crohn's disease (CD) poses a significant challenge to clinicians. With the advent of biologics, various studies have observed a reduction of recurrence after surgery. Hence, we performed a systematic review and meta‐analysis to identify the rate of POR at different time points in the era of biologic use.MethodsWe performed a literature search using Medline and Embase databases for studies investigating biologics in preventing the POR of CD. Data were extracted, and a single‐arm meta‐analysis with generalized linear mixed model and Clopper‐Pearson method for confidence interval (CI) was performed to identify endoscopic, clinical and surgical recurrence rates at 6 months and 1, 2 and 5 years postoperatively.ResultsAltogether 24 studies were included in the meta‐analysis. The endoscopic, clinical and surgical POR rate with the use of anti‐tumor necrosis factor (TNF)‐α agents at 1 year was 21.72% (95% CI 16.28%‐28.37%), 13.06% (95% CI 8.18%‐18.92%) and 3.76% (95% CI 1.37%‐9.91%), respectively. The 5‐year recurrence rate was 84.21% (95% CI 72.35%‐91.57%) and 17.49% (95% CI 9.17%‐30.80%) for endoscopic and surgical recurrence, respectively. Subgroup analyses at 1 year for the type of anti‐TNF‐α agent or the timing of initiation after surgery showed no significant difference in endoscopic, clinical and surgical recurrence rates.ConclusionsAnti‐TNF‐α agents are effective at preventing clinical, endoscopic and surgical POR of CD. The timing of initiating biological therapy after surgery has no significant effect on the rate of POR. The efficacy of infliximab and adalimumab for postoperative recurrence prevention is similar.
Durable virological response and functional cure of chronic hepatitis D after long‐term peginterferon therapy
Authors: Hercun Julian , Kim Grace E. , Da Ben L. , Rotman Yaron , Kleiner David E. , Chang Richard , Glenn Jeffrey S. , Hoofnagle Jay H. , Koh Christopher , Heller Theo 
Published: May 2021

SummaryBackgroundHepatitis delta virus (HDV) infection is the most aggressive form of chronic viral hepatitis. Response rates to therapy with 1‐ to 2‐year courses of pegylated interferon alpha (peginterferon) treatment are suboptimal.AimsTo evaluate the long‐term outcomes of patients with chronic hepatitis D after an extended course of peginterferon.MethodsPatients were followed after completion of trial NCT00023322 and classified based on virological response defined as loss of detectable serum HDV RNA at last follow‐up. During extended follow‐up, survival and liver‐related events were recorded.ResultsAll 12 patients who received more than 6 months of peginterferon in the original study were included in this analysis. The cohort was mostly white (83%) and male (92%) and ranged in age from 18 to 58 years (mean = 42.6). Most patients had advanced but compensated liver disease at baseline, a median HBV DNA level of 536 IU per mL and median HDV RNA level of 6.86 log10 genome equivalents per mL. The treatment duration averaged 6.1 years (range 0.8‐14.3) with a total follow‐up of 8.8 years (range 1.7‐17.6). At last follow‐up, seven (58%) patients had durable undetectable HDV RNA in serum, and four (33%) cleared HBsAg. Overall, one of seven (14%) responders died or had a liver‐related event vs four of five (80%) non‐responders.ConclusionsWith further follow‐up, an extended course of peginterferon therapy was found to result in sustained clearance of HDV RNA and favourable clinical outcomes in more than half of patients and loss of HBsAg in a third.
Feeling the refugee camp: Affectual research, bodies, and suspicion
Authors: Brankamp Hanno 
Published: May 2021

AbstractThis paper advances debates in camp geographies and forced migration studies by centring the methodological import of emotions and affect in research on refugee camps. Camps are often spatial expressions of compassion, fear, care, suspicion, but also incubate hope, solidarity, and feelings of belonging among encamped communities. Researchers are never insulated from these complex emotions and affects. While qualitative, ethnographic, experiential, or otherwise sensory methods continue to be widely used in this field of study, the emotional entanglements that arise from the embodied encounters between researchers, residents, and camp spaces are not yet well understood. The paper argues that it is methodologically pertinent to not simply incorporate such affectual intensities into existing readings of the camp as an exceptional space, but to understand people's differentially experienced feelings as actively shaping the camp's geography. It illustrates this argument by engaging with feelings of suspicion that pervaded my long‐term ethnographic fieldwork in Kakuma refugee camp in Kenya. Ultimately, the paper urges scholars to explore camps beyond their known capacities for controlling mobility and motion as spaces that are also imbued with feelings and sensibilities.
Pharmacokinetics of capmatinib in participants with hepatic impairment: A phase 1, open‐label, single‐dose, parallel‐group study
Authors: Chen Xinhui , Cui Xiaoming , Pognan Nathalie , Quinlan Michelle , Kapoor Shruti , Rahmanzadeh Gholamreza , Giovannini Monica , Marbury Thomas C. 
Published: May 2021

AimsCapmatinib, a mesenchymal–epithelial transition factor tyrosine kinase inhibitor, is metabolized by cytochrome P450 (CYP) 3A4 and aldehyde oxidase. In individuals with hepatic impairment, alterations in hepatobiliary excretion and metabolism could lead to higher capmatinib exposure. We compared the pharmacokinetics of a single oral dose of capmatinib 200 mg administered to participants with varying degrees of hepatic impairment vs. matched controls with normal hepatic function.MethodsThis phase 1, multicentre, open‐label, parallel‐group study enrolled adult participants with normal hepatic function and mild, moderate and severe hepatic impairments. Eligible participants received a single oral dose of 200 mg capmatinib. The pharmacokinetic parameters of capmatinib were analysed and compared across participants with impaired and normal hepatic function.ResultsOf 31 enrolled participants, 29 had an evaluable pharmacokinetic profile: normal (n = 9); mild (n = 6); moderate (n = 8); severe (n = 6). Compared with the normal group, geometric mean (GM) maximum (peak) observed plasma drug concentration after single‐dose administration decreased by 27.6% in the mild group (GM ratio [GMR] = 0.724; 90% confidence interval [CI]: 0.476–1.10), by 17.2% in the moderate group (GMR = 0.828; 90% CI: 0.563–1.22) and remained unchanged in the severe group (GMR = 1.02; 90% CI: 0.669–1.55). Compared with the normal group, GM area under the plasma concentration–time curve from time zero to infinity decreased by 23.3% in the mild group (GMR = 0.767; 90% CI: 0.532–1.11), by 8.6% in the moderate group (GMR = 0.914; 90% CI: 0.652–1.28) and increased by 24% in the severe group (GMR = 1.24; 90% CI: 0.858–1.78).ConclusionMild, moderate and severe hepatic impairment did not have a clinically relevant impact on capmatinib pharmacokinetics. No new safety findings are reported in this study.
DNA and modified vaccinia Ankara prime–boost vaccination generates strong CD8+ T cell responses against minor histocompatibility antigen HA‐1
Authors: Eldershaw Suzy A. , Pearce Hayden , Inman Charlotte F. , Piper Karen P. , Abbotts Ben , Stephens Christine , Nicol Samantha , Croft Wayne , Powell Richard , Begum Jusnara , Taylor Graham , Nunnick Jane , Walsh Donna , Sirovica Mirjana , Saddique Shamyla , Nagra Sandeep , Ferguson Paul , Moss Paul , Malladi Ram 
Published: May 2021

SummaryAllogeneic immune responses underlie the graft‐versus‐leukaemia effect of stem cell transplantation, but disease relapse occurs in many patients. Minor histocompatibility antigen (mHAg) peptides mediate alloreactive T cell responses and induce graft‐versus‐leukaemia responses when expressed on patient haematopoietic tissue. We vaccinated nine HA‐1‐negative donors against HA‐1 with a ‘prime–boost’ protocol of either two or three DNA ‘priming’ vaccinations prior to ‘boost’ with modified vaccinia Ankara (MVA). HA‐1‐specific CD8+ T cell responses were observed in seven donors with magnitude up to 1·5% of total CD8+ T cell repertoire. HA‐1‐specific responses peaked two weeks post‐MVA challenge and were measurable in most donors after 12 months. HA‐1‐specific T cells demonstrated strong cytotoxic activity and lysed target cells with endogenous HA‐1 protein expression. The pattern of T cell receptor (TCR) usage by HA‐1‐specific T cells revealed strong conservation of T cell receptor beta variable 7‐9 (TRBV7‐9) usage between donors. These findings describe one of the strongest primary peptide‐specific CD8+ T cell responses yet recorded to a DNA–MVA prime–boost regimen and this may reflect the strong immunogenicity of mHAg peptides. Prime–boost vaccination in donors or patients may prove of substantial benefit in boosting graft‐versus‐leukaemia responses.
Discovery of novel antibacterial agents: Recent developments in D‐alanyl‐D‐alanine ligase inhibitors
Authors: Qin Yinhui , Xu Linlin , Teng Yuetai , Wang Yinhu , Ma Peizhi 
Published: May 2021

AbstractBacterial infections can cause serious problems that threaten public health over a long period of time. Moreover, the continuous emergence of drug‐resistant bacteria necessitates the development of novel antibacterial agents. D‐alanyl‐D‐alanine ligase (Ddl) is an indispensable adenosine triphosphate‐dependent bacterial enzyme involved in the biosynthesis of peptidoglycan precursor, which catalyzes the ligation of two D‐alanine molecules into one D‐alanyl‐D‐alanine dipeptide. This dipeptide is an essential component of the intracellular peptidoglycan precursor, uridine diphospho‐N‐acetylmuramic acid (UDP‐MurNAc)‐pentapeptide, that maintains the integrity of the bacterial cell wall by cross‐linking the peptidoglycan chain, and is crucial for the survival of pathogens. Consequently, Ddl is expected to be a promising target for the development of antibacterial agents. In this review, we present a brief introduction regarding the structure and function of Ddl, as well as an overview of the various Ddl inhibitors currently being used as antibacterial agents, specifically highlighting their inhibitory activities, structure–activity relationships and mechanisms of action.