bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of safety of bioactive concentrate of small sea fish therapy in comorbid patients with osteoarthritis
Authors: Zimnitskaya O. V. , Petrova M. M. , Shesternya P. A. 
Published: June 2021

The article discusses the safety issues of a bioactive concentrate of small sea fish (BCSSF, Alflutop®) in the treatment of osteoarthritis (OA). The data of original studies, which were published during 2001–2021 years, from eLIBRARY, PubMed and Web of Science databases were analyzed. The selection of studies was carried out according to the following criteria: diagnosis of OA or nonspecific back pain; follow-up duration ≥1 month; intramuscular or intra-articular route of BCSSF administration; ≥30 study participants; availability of information about adverse events.The accumulated data confirm the safety of BCSSF, including in patients with high comorbidity. The drug has no significant effect on serum levels of glycemia, electrolytes and protein metabolism. These results indicate the possibility of widespread use of this drug in the treatment of OA of peripheral joints and spine in patients with comorbid diseases.
Comprehensive approach to the choice of therapy in patients with osteoarthritis at the first visit to the doctor. Expert consensus (literature review and resolution)
Authors: Lila A. M. , Tkacheva O. N. , Yakhno N. N. , Naumov A. V. , Alekseeva L. I. , Kotovskaya Yu. V. , Putilina M. V. , Kukushkin M. L. , Kochish A. Yu. , Taskina E. A. , Abuzarova G. R. 
Published: June 2021

Osteoarthritis (OA) is the most common pathology of the musculoskeletal system and is a serious medical and social problem. OA is of particular importance in elderly and senile people due to the high frequency of comorbid pathology. Pain relief is a priority in the formation of individual therapeutic programs for patients with OA, starting from their first request for medical assistance. At the same time, due to the ambiguity of existing clinical recommendations, most experts note a number of difficulties in prescribing treatment for patients with OA.The article presents a consensus position of experts regarding a complex approach to the choice of therapy in patients with OA at the initial visit to the doctor. The article discusses: current clinical guidelines for the management of patients with OA; most common problems in the management of patients with OA in real clinical practice; goals of treatment strategies for OA taking into account the risk factors for its progression; an algorithm of pain relief during initial treatment in patients with OA; prevention of OA exacerbations with the use of basic structure-modifying drugs; recommendations for the choice of non-steroidal anti-inflammatory drugs.According to experts, a rational approach to the treatment of OA is based on the combined use of non-drug and pharmacological methods with constant monitoring of therapy regimens and side effects. These recommendations can be considered disease-modifying strategies that in many cases allow improving functional status and achieving long-term remission in patients with OA.
Sexual dysfunction in women with rheumatic diseases
Authors: Teplyakova O. V. , Morozova A. A. , Popov A. A. 
Published: June 2021

Objective: to assess sexual function in female patients with rheumatoid arthritis (RA) and fibromyalgia (FM) and to identify the main risk factors of sexual dysfunction (SD).Patients and methods. 60 patients with FM (mean age 44.2±10.1 years) – Group 1; 69 patients with RA (mean age 45.0±9.6 years) – Group 2; and 100 healthy women controls (mean age 45.1±11.8 years) – Group 3 were enrolled in the study. Medical history, severity of pain at rest and during movement by visual analog scale (VAS), and anxiety and depression symptoms by hospital anxiety and depression scale (HADS) were assessed. Sexual function was evaluated by «Female Sexual Function index (FSFI)».Results and discussion. The overall sexual function score in Group 1 (12.7±9.0) was almost twice lower than in the control group (23.55±8.24, p<0.001) and in Group 2 (20.9±11, p<0.001). There was no difference between RA patients group and control group, where the average score for each of the scales was above 3 (with the exception of the «desire» scale). In FM patients all scales were below 3 points, which indicated significant SD, score on the «orgasm» scale was the lowest (1.8±0.9), and score on «absence of sexual pain» scale was the highest (2.6±1.8). SD in patients with FM was significantly driven by affective disorders presenting with anxiety and depression. Inflammatory activity and severity of pain by VAS were strongly associated with SD in RA group. The divorced person status was associated with the development of SD, regardless of nosological diagnosis.Conclusion. RA and FM have a negative impact on women's sexual function. The inflammatory disease activity is the main driver of SD in RA patients while affective disorders promote SD in FM patients.
Significance of asymptomatic hyperuricemia in ankylosing spondylitis
Authors: Balabanova R. M. , Ilyinykh E. V. , Podryadnova M. V. , Glukhova S. I. , Urumova M. M. 
Published: June 2021

Over the past decades, there has been an increase in the incidence of asymptomatic hyperuricemia (AHU), which includes an increased level (>360 μmol/L) of uric acid (UA) in the blood serum of patients with no clinical manifestations of gout. AHU is reported in various rheumatic diseases, mainly in osteoarthritis, in which AHU is one of the manifestations of the metabolic syndrome. There is relationship between AHU and pulmonary hypertension in systemic sclerosis, arterial hypertension (AH) in men with seronegative rheumatoid arthritis, extensive cutaneous psoriasis and metabolic disorders in psoriatic arthritis. There are almost no data on AHU in ankylosing spondylitis (AS), which served objective for this work.Objective: to assess the association of AHU with AS duration and activity and the presence of comorbid diseases.Patients and methods. A retrospective analysis of 48 medical histories of patients with diagnosed AS, who were treated in V.A. Nasonova Research Institute of Rheumatology from 2015 to 2019 years, whose serum UA level was >360 μmol/L.Results and discussion. More than half of patients with AS and AHU were overweight, 21% were obese. AH was diagnosed in 43.7% of patients. Stage II–III chronic kidney disease was detected in 16.7% of patients, urolithiasis – in 18.8%. 4 (8.3%) patients had diabetes mellitus. The serum UA level in patients with AS was 422.0 ± 61.6 μmol/L. In patients with AS, an association between AHU and age, duration and disease activity was noted. There was no statistically significant rela- tionship between HG and blood glucose, cholesterol, creatinine levels, body mass index. Correlation analysis revealed a statistically significant relationship between the glomerular filtration rate (GFR) and the age of patients (r=-0.54, p<0.001), the duration of the disease (r=-0.40, p<0.05), cholesterol level (r=-0.48, p=0.01), UA level (r=-0.45, p=0.03) and blood pressure (r=-0.54, p<0.001). There was no association between disease activity and GFR (p>0.05).Conclusion. In AS, an association between an increased level of UA in the blood serum and the duration and activity of the disease, and patient's age, was established.
Validation of a Russian version of the Berg Balance Scale
Authors: Suponeva N. A. , Yusupova D. G. , Zimin A. A. , Zaitsev A. B. , Yatsko K. A. , Melchenko D. A. , Rimkevichus A. A. , Zhirova E. S. , Taratukhina A. S. , Rizvanova A. S. , Gatina G. A. , Kalinkina M. E. , Piradov M. A. , Berg K. 
Published: June 2021

Objective: linguistic and cultural adaptation of the original version of Berg Balance Scale (BBS) and assessment its psychometric properties.Patients and methods. The staff of the Validation Center of International Scales and Questionnaires of the Research Center of Neurology received consent from Katherine Berg to validate the BSS in Russia. We carried out the linguocultural ratification during the validation study and prepared a Russian version of the scale. To assess the psychometric properties of the scale (reliability, validity, and sensitivity), we evaluated 55 patients (30 females and 25 males) aged 22–88 years with different neurological disorders (vascular and demyelinating diseases of the central nervous system, peripheral neuropathy, and movement disorders). We analyzed the differences of the total BBS score and the number of patients with high and low risk of falls at the end of rehabilitation compared to baseline to assess the dynamics of changes.Results and discussion. We successfully performed the translation and linguocultural adaptation of the BBS. The scale represents a high level of validity (expert score: 8.6 out of 10 points), reliability (Pearson's correlation coefficient r=0.98, р<0.0001; Cronbach's alpha α=0.94 р<0.001; Cohen's kappa κ=0.71, p<0.0001) and sensitivity (р<0.0001). After a two-week rehabilitation course, the risk of falls significantly decreased (χ2 =4.42; р=0.035); however, the level of independence of movement did not change significantly (F=0.94; р=0.636).Conclusion. The Russian version of the BBS was officially adapted based on the results of the accomplished validation study and is recommended for use both in routine clinical practice and in clinical trials by neurologists and rehabilitologists. The scale is available for downloading by QR code and on the website of Validation Center of International Scales and Questionnaires of the Research Center of Neurology.
Depression treatment in women and men with bipolar affective disorder: a comparative study
Authors: Tyuvina N. A. , Stolyarova A. E. , Balabanova V. V. , Bunkova K. M. , Efremova E. N. 
Published: June 2021

Objective: to compare depression treatment efficacy with and without antidepressants (ADs) in men and women with bipolar affective disorder (BAD).Patients and methods. We enrolled 100 patients with BAD (F31.3–F31.5 according to ICD-10), including 50 women aged 33.0 [23.0; 50.2] years and 50 men aged 37.5 [29.5; 47.2] years using prospective and retrospective methods. Various antidepressants, normothymics, antipsychotics combinations were used to treat depression. We performed a comparative analysis of treatment efficacy with and without antidepressants in men and women subgroups. Clinical assessment at the baseline and the end of 1, 2, 4, 6-th week of therapy (or at discharge) included a specially developed clinical examination chart and the following psychometric scales: Montgomery-Asberg Depression Rating Scale (MADRS), Clinical Global Impression – Severity of illness (CGI-S), Clinical Global Impression – Improvement (CGI-I).Results and discussion. Women tended to have a slower improvement in the condition compared to men. Maximum reduction in MADRS score and a CGI-I, CGI-S higher frequency of clinical improvement and remission was observed in men and women who did not receive antidepressants than patients who did not receive antidepressants. When BAD type was included in the analysis, in patients treated with antidepressants, transient symptoms of the opposite pole occurred in 24.7% of patients of both sexes with bipolar affective I disorder (BAD I) and in 16.8% with bipolar affective II disorder (BAD II). There were no significant gender differences in patients with BAD I, while women predominated in BAD II group (22.5% compared to 7.8% men). No significant treatment-emergent affective switch was observed with tricyclic antidepressants and selective serotonin and norepinephrine reuptake inhibitors in both groups (21; 16.7; 16.7% in men and 28; 21.8; 12.5% in women, respectively). The assessment of intermission revealed that women were significantly more likely to have shorter periods between phases (42% compared to 22% in men). In addition, women were significantly more likely to have shorter periods between phases (42% compared to 22% in men) when the intermission duration was included in the analysis. In some patients with severe depression and infective first-line therapy (anticonvulsants and atypical antipsychotics), antidepressants prescription can increase treatment effectiveness. However, several factors should be considered, such as BAD type and variant, depression severity, treatment-emergent affective switch in history, and gender.Conclusion. A decision about antidepressants' dosage and treatment duration requires a dynamic follow-up of the patient in order to discontinue the antidepressants as fast as possible and decrease the risk of treatment-emergent affective switch and shortening of remission period.
Oxcarbazepine as the initial monotherapy of focal epilepsy in adolescents and adults
Authors: Pushkar T. N. , Azhigova A. M. , Vlasov P. N. , Kozhokaru A. B. 
Published: June 2021

Oxcarbazepine (OXC) is an antiepileptic drug (AED) used in children and adults as initial and adjunctive therapy for focal epilepsy (FE). It has been used in Russia since 2007; however, only a few studies have been published on its use in Russian patients to date.Objective: to assess the effectiveness and tolerability of OXC as initial therapy for FE in adults and adolescents, as well as to study epileptiform activity index (EAI) changes during treatment and its relationship with treatment effectiveness and tolerability.Patients and methods. We evaluated treatment effectiveness and tolerability and EAI in 89 adults with newly diagnosed FE aged 15–75 years for 12 months. Patients were divided into three subgroups according to the OXC treatment regimen. Side Effects of Anti-Epileptic Drugs (SIDAED) scale was used to assess treatment tolerability. Retention rate and seizure frequency changes were used to evaluate treatment effectiveness. EAI changes were assessed with video electroencephalography monitoring (4–24 h) during each visit (baseline, after 1, 3, 6, and 12 months).Results and discussion. The retention rate in patients on OXC monotherapy after 12 months was 71.9%, almost one-half of them (46.1%) achieved sustained remission. More than half of patients (52.9%) were prescribed 1200 mg/day of OXC, 12.3% – <1200 mg/day, and only in 6.7% of patients the dose exceeded 1200 mg/day. Side effects were observed in 9% of the cases. A 2.54-fold reduction in mean EAI index was observed during follow-up representing treatment effectiveness.Conclusion. OXC, as the initial AED for FE, has demonstrated high treatment effectiveness and tolerability. In addition, total EAI 2.5-fold reduction allows its usage as an additional quantitative marker of OXC treatment effectiveness.
Can Unconditional In-Kind Transfers Keep Children Out of Work and in School? Evidence from Indonesia
Authors: Jayawardana Danusha , Baryshnikova Nadezhda V. , Pham Ngoc Thien Anh 
Published: June 2021

Abstract
Child labour is a global issue which creates a need for evidence-based interventions such as cash and in-kind transfers. However, there is limited evidence about the effect of in-kind transfers on child labour, impeding policy development. We address this gap by examining the impacts of an unconditional in-kind transfer, a nation-wide subsidised rice program, on child labour and schooling using longitudinal household survey data from Indonesia. To identify the causal effect, we use coarsened exact matching with difference-in-differences estimator. The results indicate that the program is effective in decreasing the probability of working for boys though it does not have a significant impact on the probability of schooling. However, as an unconditional in-kind transfer, its ability to decrease child work for boys, especially of those who are both working and attending school, provides an important policy implication on how a food subsidy program can indirectly influence child wellbeing.
Cash-Management in Times of Covid-19
Authors: Alvarez Fernando , Argente David 
Published: June 2021

Abstract
The incidence of COVID-19 has systematically decreased households’ use of cash as means of payment as well as the average size and frequency of cash withdrawals. We argue that the structure of Baumol–Tobin type inventory theoretical models and their extensions can be used to separate the confounding factors, such as the desired level of consumption and the choice of the fraction of consumption paid in cash, from the cash management behavior, i.e. the size and frequency of cash withdrawals. Using this insight we argue that the observed cash management is consistent with COVID-19 increasing the fixed cost of withdrawing cash. We use detailed data on ATM cash disbursements in Argentina, Chile, and the US to estimate how much the pandemic has changed the transaction cost of using cash. This estimation shows that if the intensity of the virus doubles in a county, cash transaction cost increases by approximately 2%. The results from Argentina, Chile, and the US are remarkably similar and robust to several forms of measurement error and endogeneity.
Putting the argument back into argument structure constructions
Authors: Romain Laurence 
Published: June 2021

AbstractThis paper shows that low-level generalisations in argument structure constructions are crucial to understanding the concept of alternation: low-level generalisations inform and constrain more schematic generalisations and thus constructional meaning. On the basis of an analysis of the causative alternation in English, and more specifically of the theme (i.e., the entity undergoing the event denoted by the verb), I show that each construction has its own schematic meaning. This analysis is conducted on a dataset composed of 11,554 instances of the intransitive non-causative construction and the transitive causative construction. The identification of lower-level generalisations feeds into the idea that language acquisition is organic and abstractions are formed only gradually (if at all) from exposure to input. So far, most of the literature on argument structure constructions has focused on the verb itself, and thus fails to capture these generalisations. I make up for this deficit through an in-depth analysis of the causative alternation.
Synthesis of zeolite from fly ash and its adsorption of phosphorus in wastewater
Authors: Zhang Kecheng , Van Dyk Lizelle , He Dongsheng , Deng Jie , Liu Shuang , Zhao Hengqin 
Published: June 2021

Abstract
Using synthetic zeolite from fly ash to treat high concentration phosphorus wastewater does not only improve the utilization of fly ash as solid waste but also reduce the environmental pressure caused by eutrophication. A synthetic zeolite was prepared from coal fly ash by one-step hydrothermal synthesis and applied for phosphorus adsorption from industrial wastewater (∼8,000 mg-P/L), and its adsorption characteristics and performance were studied. The results indicated that the product was a well-crystallized Na-P1 zeolite with typical morphology of plate- and rod-shaped crystals. Compared with the original fly ash, the specific surface area and average pore volume of the synthetic zeolite were nine and six times larger than the fly ash, reaching 43.817 m2/g and 0.122 cm3/g. The results from phosphorus adsorption onto the synthetic zeolite showed that the synthetic zeolite had good phosphorus adsorption properties. The adsorption process highly conformed to the pseudo-second-order kinetic model with the regression coefficient R
2 of 0.998. Phosphorus adsorption on the synthetic zeolite was fitted to the Langmuir monolayer adsorption model, and the regression coefficient R
2 was 0.989. The maximum phosphorus adsorption capacity was 84.4 mg-P/g-zeolite.
Microwave absorption properties of Zn-doped barium ferrite (BaFe12-x
Zn
x
O19) decorated reduced graphene oxide
Authors: Niasar Mojtaba Moslehi , Molaei Mohammad Jafar , Aghaei Alireza 
Published: June 2021

Abstract
Reduced graphene oxide has attracted great interest for application as microwave absorbing materials during recent years. Barium ferrite (BaFe12O19) is also a hard magnetic material with microwave absorbing properties. In this research, Zn-doped barium ferrite/reduced graphene oxide nanocomposites were synthesized and their magnetic and microwave absorption properties were studied. Phase analysis, particle morphology, magnetic properties, and microwave absorption properties were investigated by means of X-ray diffraction, field-emission scanning electron microscopy, vibrating sample magnetometry, and vector network analysis, respectively. Electron microscopy images showed that reduced graphene oxide nanosheets are decorated with barium ferrite nanoparticles. Zn-doping in the reduced graphene oxide/BaFe12-x
Zn
x
O19 (x = 0.0, 0.2, 0.4, and 0.6) nanocomposites caused an increase in the saturation magnetization from 30.76 to 32.69 emu g–1 for Zn = 0.4. Maximum reflection loss was increased from –7.39 dB to –13.50 dB by Zn doping for x = 0.4 in the nanocomposite consisting of 10 wt.% of reduced graphene oxide/BaZn0.4Fe11.6O19. The microwave absorption characteristics are discussed based on the permittivity and permeability values of the nanocomposites.
Lying vs. misleading: The adverbial account
Authors: García-Carpintero Manuel 
Published: June 2021

AbstractWe intuitively make a distinction betweenlyingandmisleading. As several philosophers have pointed out, on the account of this distinction favored here – theadverbialaccount, as I’ll call it – it provides evidence on the theoretical notion ofwhat is saidand the related theoretical distinction between semantics and pragmatics. For, on that account, the distinction tracks whether or not the content and the assertoric force with which it is presented are semantically conveyed. On an alternative (assertoric)commitmentaccount, the difference between lying and misleading is predicated instead on the strength of assertoric commitment. One lies when one presents with full assertoric commitment what one believes to be false; one merely misleads when one presents it with short-of-full assertoric commitment, by merely hinting or otherwise implying it. Here I’ll present the debate confronting the two accounts, and I’ll provide support for the adverbial account and its methodological application.
Exemplarity, Exegesis, & Ethnography: Abraham in Pseudo-Hegesippus as a Test Case for Biblical Reception in Christian Late Antiquity
Authors: Bay Carson 
Published: June 2021

AbstractExemplarity, ethnography, and exegesis are three forms of cultural practice well known to the ancient Mediterranean world. The use of role models, the ‘writing’ of peoples, and the interpretation of authoritative writings (i.e. “Scriptures”) were ways in which many authors of Greco-Roman and Judeo-Christian antiquity situated themselves and others within history. Here I argue that the biblical patriarch Abraham, as received within the late antique Christian text called Pseudo-Hegesippus (On the Destruction of Jerusalem), provides a quintessential example of these scribal-rhetorical habits in action. The upshot of this study is that key figures like Abraham were integral tools for doing the things that certain interested ancient writers were trying to do, and as such these figures constitute appropriate, even necessary, objects of research for those seeking to understanding ancient Mediterranean texts, authors, and readers.