bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thymic carcinoma and branchial cyst in a cat
Authors: Tindale Catherine , Jasensky Anne‐Katherine , O'Brien Kevin M. , Martineau Henny M. , Lee Karla 
Published: October 2021

AbstractA 10‐year‐old female spayed Maine Coon presented with lethargy, weight loss and severe dyspnoea. Radiographs showed mediastinal enlargement and marked pleural effusion. Thoracocentesis yielded a highly protein‐rich transudate with macrophages predominating. Computed tomography identified a large cystic mediastinal structure with a typical peripheral contrast‐enhancing rim, but fluid contents with a high attenuation of 35HU and internal contrast‐enhancing projections raising concern for neoplasia. However, mediastinal cytology failed to demonstrate neoplastic cells, but instead ciliated columnar epithelium most consistent with a thymic branchial cyst. The cat underwent median thoracotomy and mediastinal mass resection and is well 6 months postoperatively, with no evidence of recurrence. Histopathology with immunohistochemistry diagnosed thymic carcinoma, with branchial duct remnants. This report highlights the diagnostic challenge of mediastinal cystic lesions and the possible concurrent presence of a non‐neoplastic and a malignant neoplastic process.
Cutaneous inflammatory lobular capillary haemangioma in a guinea pig (Cavia porcellus)
Authors: Coppola* Giovanni , Helm Jenny Rose , Marchesi Francesco , Morris Joanna Siriol 
Published: October 2021

AbstractA 3‐year‐old entire male guinea pig (Cavia porcellus) was presented with a mass on the neck, which was excised surgically. Histological examination and immunohistochemistry confirmed the mass to be a tumour of endothelial origin consistent with an inflammatory lobular capillary haemangioma, despite some microscopic features triggering an initial suspicion of histological malignancy. Following surgical treatment, the patient was still alive with no evidence of local tumour recurrence 34 months after diagnosis. This case report illustrates an excellent outcome of a guinea pig with a tumour of endothelial origin arising from the skin. Surgical treatment alone appears an effective treatment for these lesions.
Impact of COVID‐19 on agricultural production and distribution in South Asia
Authors: Ahmed Jasim Uddin , Akter Saifun , Majumder Kausar Ahmed 
Published: October 2021

AbstractCOVID‐19 conveyed threats to the development of social life and the economy. Social distancing has changed the way of living, with a profound impact on food and agriculture. With this concern, the study was conducted to assess the impact of COVID‐19 on agricultural production and distribution in South Asia. Bangladesh, India, and Pakistan were selected as the study countries since larger agricultural production countries with higher virus invasion numbers posed higher vulnerability than others. It is necessary to unfold the impacts and policy on the agricultural sector so that losses can reduce. The secondary data were taken from different sources. The study proved that limited transportation, shortages of agricultural labor, export, and import restriction hampered agricultural production and distribution in South Asia. Livestock, vegetable, fruit, and fishing sector were more affected than the crop sector. Small poultry farms were closed, milk was discarded, and rotted fruits and vegetables were a source of concern. Different policies were implemented by the governments to recover from production losses. Proper storage management and farm mechanization may reduce the loss of production. Decentralization efforts of government through local (political and co‐operative association) leaders may place the agricultural product to the market at least health hazards.
Untargeted metabolomics approaches to improve casework in clinical and forensic toxicology—“Where are we standing and where are we heading?”
Authors: Steuer Andrea Eva , Brockbals Lana , Kraemer Thomas 
Published: October 2021

AbstractClinical toxicology (CT) and forensic toxicology (FT) represent two disciplines of toxicology dedicated to the qualitative and quantitative analysis and respective interpretation of alcohol, drugs of abuse (DOA), over the counter (OTC), and prescription drugs or poisons, mainly in humans. Analytical challenges, such as the transient occurrence of new psychoactive substances (NPS) on the (il)legal drug market, insufficiently long detection windows of some DOAs, or the lack of objective measures to unambiguously proof sample manipulation as well as interpretative issues, for instance, the difficulty to discriminate occasional users from chronic/addictive ones still require further evaluation and research, though. Metabolomics is a rather new research field, aiming for qualitative, and quantitative analysis of endogenous compounds (small molecules with a molecular weight < 1000 Da) in an organism to identify changes related to a certain stimulus, for example, a drug intake. Over the last years, metabolomics has been established as a valuable tool in different disciplines, including very recently CT and FT. Analytical techniques usually applied include nuclear magnetic resonance and majorly hyphenated high‐resolution mass spectrometry (HR‐MS), similar to the instrumentation used in CT and FT. We will summarize practical considerations for each step of a typical untargeted metabolome workflow (experimental set‐up, sample collection and storage, analysis, data processing, statistics, and identification) in CT and FT, provide an update on the current applications of untargeted metabolome profiling and will critically discuss its benefits or lack thereof within the particular field.This article is categorized under:
Toxicology > Analytical
Toxicology > Metabolomics
Toxicology > New Psychoactive Substances
The massive supermembrane on a knot
Authors: Garcia del Moral M. P. , Leon P. , Restuccia A. 
Published: October 2021

Abstract
We obtain the Hamiltonian formulation of the 11D Supermembrane theory non-trivially compactified on a twice punctured torus times a 9D Minkowski space-time. It corresponds to a M2-brane formulated in 11D space with ten non-compact dimensions. The critical points like the poles and the zeros of the fields describing the embedding of the Supermembrane in the target space are treated rigorously. The non-trivial compactification generates non-trivial mass terms appearing in the bosonic potential, which dominate the full supersymmetric potential and should render the spectrum of the (regularized) Supermembrane discrete with finite multiplicity. The behaviour of the fields around the punctures generates a cosmological term in the Hamiltonian of the theory.The massive supermembrane can also be seen as a nontrivial uplift of a supermembrane torus bundle with parabolic monodromy in M9 × T2. The moduli of the theory is the one associated with the punctured torus, hence it keeps all the nontriviality of the torus moduli even after the decompactification process to ten noncompact dimensions. The formulation of the theory on a punctured torus bundle is characterized by the (1, 1) − knots associated with the monodromies.
Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study
Authors: Jäger Anna-Thekla P. , Huntenburg Julia M. , Tremblay Stefanie A. , Schneider Uta , Grahl Sophia , Huck Julia , Tardif Christine L. , Villringer Arno , Gauthier Claudine J. , Bazin Pierre-Louis , Steele Christopher J. 
Published: October 2021

AbstractIn motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific motor learning are less well understood. Previous research has established that plastic changes following motor learning can be divided into stages including fast learning, slow learning and retention. A description of how resting state functional connectivity after sequence-specific motor sequence learning (MSL) develops across these stages is missing. This study aimed to identify plastic alterations in whole-brain functional connectivity after learning a complex motor sequence by contrasting an active group who learned a complex sequence with a control group who performed a control task matched for motor execution. Resting state fMRI and behavioural performance were collected in both groups over the course of 5 consecutive training days and at follow-up after 12 days to encompass fast learning, slow learning, overall learning and retention. Between-group interaction analyses showed sequence-specific decreases in functional connectivity during overall learning in the right supplementary motor area (SMA). We found that connectivity changes in a key region of the motor network, the superior parietal cortex (SPC) were not a result of sequence-specific learning but were instead linked to motor execution. Our study confirms the sequence-specific role of SMA that has previously been identified in online task-based learning studies, and extends it to resting state network changes after sequence-specific MSL.
Classification of two-phase flow patterns using multifractal analysis of pressure oscillations
Authors: Mosdorf R. , Litak G. , Górski G. , Augustyniak J. , Zaborowska I. 
Published: October 2021

AbstractThe two-phase flow patterns (air–water) in horizontal square minichannel (3 × 3 mm) has been analysed. The multifractal analysis of pressure drop fluctuations was used for qualitative assessment of two-phase flow patterns. The results of the complexity analysis using the multifractal spectral width (Δh) are presented. The proposed method allows us to identify the following two-phase flow patterns: micro-bubbles flow, micro- and minibubbles flow, micro- and mini-bubbles with confined bubbles flow, slug flow, stratified flow. The obtained results confirm that this type of analysis can be considered as an alternative way of identification of two-phase flow patterns in the minichannel. The work also focuses on the discussion of the occurrence and identification of bubbles churns in slugs and churns.
Evaluation of the effects of food intake on task engagement based on psychophysiological states
Authors: Kurogi Nanako , Sakiyama Kanako , Tominaga Shigeru , Toyama Yoshio , Nagumo Kent , Oiwa Kosuke , Nozawa Akio 
Published: October 2021

AbstractThe objective of this study was to evaluate the effects of food intake on performance and task engagement based on psychophysiological states. The experiment was conducted under two conditions: taking a break with his eyes opened between the repeated tracking tasks (Control), and taking a break with food intake (Intake). We found the rate of deterioration of the distance between target pointer and the mouse cursor, a performance index, showed significant differences between the two conditions. Significant differences were also found between the two conditions in all assessment items of subjective feelings. Considering the hemodynamic parameters and nasal skin temperature responses, it was found that the approach to the second task was different in the two conditions. Therefore, due to food intake between repeated tasks, psychological responses such as “Awareness” and “Refreshment” were maintained. Hence, it was confirmed that food intake stimulated positive task engagement in the task and maintained performance.
3D sound spatialization with game engines: the virtual acoustics performance of a game engine and a middleware for interactive audio design
Authors: Fırat Hasan Baran , Maffei Luigi , Masullo Massimiliano 
Published: October 2021

AbstractThis study analyses one of the most popular game engines and an audio middleware to reproduce sound according to sound propagation physics. The analysis focuses on the transmission path between the sound source and the receiver. Even if there are several ready-to-use real-time auralization platforms and software, game engines' use with this aim is a recent study area for acousticians. However, audio design needs with game engines and the limits of their basic releases require additional tools (plugins and middleware) to improve both the quality and realism of sound in virtual environments. The paper discusses the use of Unreal Engine 4 and Wwise's 3D audio production methods in a set of different test environments. It assesses their performance in regard to a commercial geometrical acoustics software. The results show that the investigated version of the game engine and its sound assets are insufficient to simulate real-world cases and that significant improvements can be achieved with use of the middleware.
The new WEB-accessible online database of the Mössbauer effect data center
Authors: Klencsár Zoltán , Wang Junhu , Ge Rile , Zhou Wenhui , Liu Duorong , Rykov Alexandre I. , Zhang Tao 
Published: October 2021

AbstractThe web-accessible online database (WAD) of the Mössbauer Effect Data Center (MEDC) is one of the worldwide available information services provided by MEDC to the scientific community. It is based on the uniquely wide scope Mössbauer spectroscopy database that has been compiled and maintained by MEDC since the 1960’s. Following enhancements applied to the capabilities of the MEDC core database in connection with the development of a new database management software named “MEDC DBM”, the development of a new web-accessible online database (MEDC WAD) was started in 2019. Here we introduce the current state and the main features of the newly developed MEDC WAD system with emphasis put on its novel and rather unique attributes that can effectively aid the scientific research process in the field of Mössbauer spectroscopy.
Zur transgenerationalen Traumatisierung
Authors: Dunkel Florian 
Published: October 2021

ZusammenfassungIm vorliegenden Artikel derZeitschrift für Psychodrama und Soziometriewird das Phänomen der transgenerationalen Traumatisierung unter besonderer Berücksichtigung möglicher kollektiver Faktoren behandelt. Es werden Ansätze beschrieben, wie sich das Phänomen ätiologisch erklären lässt und wie es in der Psychotherapie erkannt und bearbeitet werden kann.
Fluid Flow Stimulation Modulates Expression of S100 Genes in Normal Breast Epithelium and Breast Cancer
Authors: Fuh Kenneth F. , Withell Jessica , Shepherd Robert D. , Rinker Kristina D. 
Published: October 2021

Abstract
Introduction
S100 proteins are intracellular calcium ion sensors that participate in cellular processes, some of which are involved in normal breast functioning and breast cancer development. Despite several S100 genes being overexpressed in breast cancer, their roles during disease development remain elusive. Human mammary epithelial cells (HMECs) can be exposed to fluid shear stresses and implications of such interactions have not been previously studied. The goal of this study was to analyze expression profiles of S100 genes upon exposing HMECs to fluid flow.

Methods
HMECs and breast cancer cell lines were exposed to fluid flow in a parallel-plate bioreactor system. Changes in gene expression were quantified using microarrays and qPCR, gene-gene interactions were elucidated using network analysis, and key modified genes were examined in three independent clinical datasets.

Results
S100 genes were among the most upregulated genes upon flow stimulation. Network analysis revealed interactions between upregulated transcripts, including interactions between S100P, S100PBP, S100A4, S100A7, S100A8 and S100A9. Overexpression of S100s was also observed in patients with early stage breast cancer compared to normal breast tissue, and in most breast cancer patients. Finally, survival analysis revealed reduced survival times for patients with elevated expression of S100A7 and S100P.

Conclusion
This study shows that exposing HMECs to fluid flow upregulates genes identified clinically to be overexpressed during breast cancer development, including S100A7 and S100P. These findings are the first to show that S100 genes are flow-responsive and might be participating in a fundamental adaptation pathway in normal tissue that is also active in breast cancer.
ASCO 2021 highlights head and neck cancer: nasopharyngeal carcinoma
Authors: Fuereder Thorsten 
Published: October 2021

SummaryDuring the ASCO 2021 virtual meeting, multiple clinically relevant studies were presented addressing open questions regarding the therapy of nasopharyngeal carcinomas (NPC): Is immunotherapy plus chemotherapy the new first line standard of care for patients in the recurrent/metastatic setting? Is adjuvant therapy with capecitabine in high risk NPC patients post chemoradiation (CRT) beneficial? Is there a role for treatment intensification by adjuvant metronomic capecitabine in NPC patients post induction chemotherapy and CRT? This article summarizes the most significant NPC studies presented at the ASCO 2021 virtual meeting and discusses the data in the context of the current literature.
Prise en charge de la diverticulite aiguë
Authors: Martin David , Hahnloser Dieter , Faes Seraina 
Published: October 2021

RésuméLa prévalence de la maladie diverticulaire colique est en augmentation au niveau mondial, ce qui est probablement en lien avec des changements de mode de vie. Bien qu’elle reste plus fréquente chez les patients âgés, une augmentation spectaculaire de son incidence a été observée dans les groupes d’âge plus jeunes ces dernières années. La diverticulite aiguë est une des conditions cliniques les plus fréquemment rencontrées par les médecins généralistes, les gastroentérologues ainsi que les chirurgiens. Comment diagnostiquer, classifier, et prendre en charge cette pathologie? Le but de cette revue est de présenter un aperçu des preuves existantes et de décrire son management.
Two Influential Concepts: Socialist Legality and Constitutional Identity and Their Impact on the Independence of the Judiciary
Authors: Gardos-Orosz Fruzsina 
Published: October 2021

AbstractIn this Article, I suggest considering linkages of a theoretical, and continuities of a sociological nature between on the one hand, the concept and the practical use of socialist legality in Socialist Hungary—with particular regard to the period following the judicial reform of 1954—and on the other hand, the concept of constitutional identity as it has developed in the Fundamental Law in Hungary, with particular regard to the period since the 2011 judicial reform. The Article highlights surprising similarities in the politically determined legislative intention in these two periods to form embracing, quasi legal concepts, which in themselves seem to differ fundamentally, although the similarities in their nature and in the specific constitutional practice are attention-grabbing. The interpretation of the role of state institutions, and especially the judicial role, lead one to think that despite the explicit rejection of the Socialist era in Article U) of the Fundamental Law in Hungary, the new constitutional regime has familiar attitudes to the understanding of the rule of law and the role of the judiciary in promoting the enforcement of the new, supra legal concepts of a transformative nature, which, however, are filled in with the ruling political ideology, whether it be socialist legality or national constitutional identity.
Higher-dimensional Auslander–Reiten theory on (d+2)-angulated categories
Authors: Zhou Panyue 
Published: October 2021

AbstractLet
$\mathscr{C}$
be a
$(d+2)$
-angulated category with d-suspension functor
$\Sigma^d$
. Our main results show that every Serre functor on
$\mathscr{C}$
is a
$(d+2)$
-angulated functor. We also show that
$\mathscr{C}$
has a Serre functor
$\mathbb{S}$
if and only if
$\mathscr{C}$
has Auslander–Reiten
$(d+2)$
-angles. Moreover,
$\tau_d=\mathbb{S}\Sigma^{-d}$
where
$\tau_d$
is d-Auslander–Reiten translation. These results generalize work by Bondal–Kapranov and Reiten–Van den Bergh. As an application, we prove that for a strongly functorially finite subcategory
$\mathscr{X}$
of
$\mathscr{C}$
, the quotient category
$\mathscr{C}/\mathscr{X}$
is a
$(d+2)$
-angulated category if and only if
$(\mathscr{C},\mathscr{C})$
is an
$\mathscr{X}$
-mutation pair, and if and only if
$\tau_d\mathscr{X} =\mathscr{X}$
.
Do women with autonomy in the household experience less intimate partner violence in Malawi? Evidence from the 2015–16 Demographic and Health Survey
Authors: Forty James 
Published: October 2021

AbstractIn Malawi, the prevalence of intimate partner violence (IPV), or closely related violence, is estimated at 42% according to the 2015–16 Malawi Demography and Health Survey (MDHS). This study investigated the association between women’s autonomy in household decision-making participation as well as sexual autonomy and IPV among married and cohabiting women aged 15–49 years in Malawi. Secondary data were taken from the 2015–16 MDHS. Multivariate analysis was performed using a stepwise forward logistic (binary) regression model to assess the association of dimensions of women’s autonomy in the household and selected control variables with IPV. No association was found between dimensions of women’s autonomy in the household and IPV. However, other variables did have an association with some form of IPV, namely women justifying wife beating, having a jealous partner, being accused of unfaithfulness by their partner, having a partner who drinks alcohol and having a partner with another woman or more. In addition, religion, ethnicity, women education level and women’s occupation were found to be associated with the risk of experiencing IPV. The study recommends policy interventions aimed at supporting youth, especially girls, to complete secondary education before they marry or cohabit; the development of accessible and affordable psycho-social counselling specialists and platforms for married and cohabiting couples; nationwide rigorous advocacy and civic education on IPV; and enforcement of Malawi’s 2006 domestic violence law.
Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder
Authors: Zhang Yi , Ku Yixuan , Sun Junfeng , Daskalakis Zafiris J. , Yuan Ti-Fei 
Published: October 2021

AbstractBackgroundRepetitive transcranial magnetic stimulation has been employed to treat drug dependence, reduce drug use and improve cognition. The aim of the study was to analyze the effectiveness of intermittent theta-burst stimulation (iTBS) on cognition in individuals with methamphetamine use disorder (MUD).MethodsThis was a secondary analysis of 40 MUD subjects receiving left dorsolateral prefrontal cortex (L-DLPFC) iTBS or sham iTBS for 20 times over 10 days (twice-daily). Changes in working memory (WM) accuracy, reaction time, and sensitivity index were analyzed before and after active and sham rTMS treatment. Resting-state EEG was also acquired to identify potential biological changes that may relate to any cognitive improvement.ResultsThe results showed that iTBS increased WM accuracy and discrimination ability, and improved reaction time relative to sham iTBS. iTBS also reduced resting-state delta power over the left prefrontal region. This reduction in resting-state delta power correlated with the changes in WM.ConclusionsPrefrontal iTBS may enhance WM performance in MUD subjects. iTBS induced resting EEG changes raising the possibility that such findings may represent a biological target of iTBS treatment response.