bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlating MRI-Based Brain Volumetry and Cognitive Assessment in Down Syndrome Patients
Authors: Hamadelseed Osama , Skutella Thomas 
Published: December 2021

Abstract
INTRODUCTION: Down syndrome (DS) is the most common genetic cause of intellectual disability. Here, we use magnetic resonance imaging (MRI) on children and adults with DS to characterize changes in the volume of specific brain structures involved in memory and language and their relationship to features of cognitive-behavioral phenotypes.METHODS: Thirteen children and adults with the DS phenotype and 12 age- and gender-matched healthy controls were analyzed by MRI and underwent a psychological evaluation for language and cognitive abilities.RESULTS: The neuropsychological profile of DS patients showed deficits in different cognition and language domains in correlation with reduced volumes of specific regional and subregional brain structures.CONCLUSIONS: The memory functions and language skills affected in our DS patients correlate significantly with the reduced volume of specific brain regions, allowing us to understand DS's cognitive-behavioral phenotype. Our results provide an essential basis for early intervention and the design of rehabilitation management protocols.
FSH Promotes Rat Follicle Development Through Inhibition of the Hippo Signalling Pathway
Authors: Chen Tairen , Wu Mengjing , Dong Yuting , Kong Bin , Cai Yufang , Hei Changchun , Wu Kai , Zhao Chengjun , Chang Qing 
Published: December 2021

Abstract
Purpose: Whether FSH promotes follicle growth by inhibiting the Hippo signalling pathway.METHODS: Ovaries were cultured in vitro into a control group (no intervention), an FSH group (0.3 IU/mL FSH), and a VP group (10 µg/mL vetiporfin). HE staining and follicle counts were performed at each stage after 3 hours of in vitro culture. Immunohistochemistry was performed to study the expression levels of LATS2, YAP, PLATS2, and PYAP, and their expression levels in each group were also analysed by Western blot.The number of secondary follicles was significantly increased in the FSH group, the arrangement of granulosa cells was neater, the nuclear fixation was reduced, and the number of atretic follicles was decreased in the VP group. The number of secondary follicles was significantly increased, the number of atretic follicles was reduced, and granulosa cell nuclear consolidation was reduced in the VP+FSH group. Immunohistochemistry showed that LATS2 and YAP expression levels were significantly increased and PLATS2 and PYAP expression levels were relatively decreased in the FSH group, PYAP and PLATS2 expression levels were significantly increased and YAP expression was significantly decreased in the VP group, and YAP and LATS2 expression levels were significantly increased and PYAP and PLATS2 expression levels were significantly decreased in the VP+FSH group. By Western blot, LATS2 and YAP were elevated and PYAP and PLAT2 were decreased in the FSH group, LATS2 and YAP were decreased and PYAP and PLATS were significantly elevated in the VP group, and LATS2 and YAP were elevated and PYAP and PLATS2 were decreased in the VP+FSH group.CONCLUSION: FSH promotes follicle development by inhibiting the Hippo signalling pathway.
ADP Based Fault-Tolerant Tracking Control for Underactuated AUV with Actuators Faults via Neural Network Observer
Authors: Che Gaofeng , Yu Zhen 
Published: December 2021

Abstract
In this work, the fault-tolerant tacking control issue of underactuated autonomous underwater vehicle (AUV) with actuators faults is investigated. Firstly, an output-feedback error tacking system is constructed based on the theoretical model of underactuated AUV with actuators faults. Then, an adaptive dynamic programming (ADP) based fault-tolerant control controller is developed. In our proposed control scheme, a neural-network observer is designed to approximate the system states with actuators faults. A novel ADP scheme is constructed with critic neural network and action neural network in order to reduce the jitter in the control input and improve the tracking accuracy. Based on Lyapunov approach, the stability of the error tracking system is guaranteed by the proposed controller. At last, the simulation results show that the underactuated AUV achieves better tracking performance.
Pharmaceutical Intervention for Adverse Events Improves Quality of Life in Patients With Cancer Undergoing Outpatient Chemotherapy
Authors: Fujii Hironori , Ueda Yukino , Hirose Chiemi , Ohata Koichi , Sekiya Kumiko , Kitahora Mika , Sadaka Shiori , Yamamoto Senri , Watanabe Daichi , Kato-Hayashi Hiroko , Iihara Hirotoshi , Kobayashi Ryo , Kaburaki Miho , Matsuhashi Nobuhisa , Takahashi Takao , Makiyama Akitaka , Yoshida Kazuhiro , Hayashi Hideki , Suzuki Akio 
Published: December 2021

Abstract
PurposeThe effect of pharmaceutical intervention to treat adverse events on quality of life (QOL) in outpatients receiving cancer chemotherapy is unclear. We investigated whether pharmaceutical intervention provided by pharmacists in collaboration with physicians improves QOL with outpatient cancer chemotherapy. MethodsWe conducted a single-center retrospective descriptive study of pharmaceutical intervention for patients receiving outpatient cancer chemotherapy at Gifu University Hospital between September 2017 and July 2020. We assessed patient QOL using the Japanese version of the EuroQol 5 Dimension5 Level (EQ-5D-5L). Adverse events were graded using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. We compared the EQ-5D-5L utility value and incidence of grade 2 or higher adverse events before and after pharmaceutical intervention. ResultsOur analysis included 151 patients who underwent 210 chemotherapy cycles. Pharmaceutical intervention significantly improved patients’ EQ-5D-5L utility values from 0.8197 to 0.8603 (P < 0.01). EQ-5D-5L utility values were significantly improved after pharmaceutical intervention for nausea and vomiting (pre-intervention 0.8145, post-intervention 0.8603, P = 0.016), peripheral neuropathy (pre-intervention 0.7798, post-intervention 0.7988, P = 0.032) and pain (pre-intervention 0.7625, post-intervention 0.8197, P = 0.035). Although not statistically significant, the incidence of grade 2 or higher adverse events, including nausea and vomiting, dermopathy, pain, oral mucositis, diarrhea and dysgeusia, tended to be lower post-intervention than pre-intervention. ConclusionsPharmaceutical intervention by pharmacists in collaboration with physicians may improve QOL in patients undergoing outpatient cancer chemotherapy.
Assessment of the empirical methods for the development of the synthetic unit hydrograph: a case study of a semi-arid river basin
Authors: Shaikh Mohamedmaroof P. , Yadav Sanjaykumar M. , Manekar Vivek L. 
Published: December 2021

Abstract
This study aims to assess various empirical synthetic unit hydrograph (SUH) methods and find the best method. Ideally, each river should have a definite rain gauge station (RGS) to get sufficient rainfall data that is available for carrying out meaningful analysis. The provisions of Indian Standard (IS) 4987:1994 determined the optimum number of RGS. In the absence of RGS, the SUH is recommended. SUHs have been developed using various methods such as Snyder's, Taylor and Schwarz, Soil Conservation Service, Mitchell's and Central Water Commission (CWC). In the present study, the Rel River Basin (RRB) is considered as the study area which has two existing RGS. IS 4987:1994 suggested that four RGS are required for more reliable rainfall data. Various efficiency criteria such as Correlation Coefficient, Pearson Coefficient, Nash Sutcliffe Efficiency, Index of Agreement, Normalized Root Mean Square Error, Mean Absolute Error, Root Mean Square Error and Kling-Gupta Efficiency have been used to compare SUH methods. The ranking of SUH methods was reported based on the compound factor (CF) through efficiency criteria. The 1.125 CF was observed as the minimum for the CWC method and recommended for determining peak discharge and timing for the study area.
Evaluating the resilience of a full-scale down-flow hanging sponge reactor to shock-loadings
Authors: Onodera Takashi , Okubo Tsutomu , Takayama Daisuke , Syutsubo Kazuaki , Yamaguchi Takashi , Uemura Shigeki , Ohashi Akiyoshi , Harada Hideki 
Published: December 2021

Abstract
The effect of shock-loading on the performance of a full-scale down-flow hanging sponge (DHS), used to treat effluent from an up-flow anaerobic sludge blanket treating municipal sewage, was evaluated. This full-scale DHS reactor comprises a polyurethane sponge that retains the sludge. It has a capacity of 500 m3/day and, at the time of this study, had been operating at a sewage treatment plant in India for more than 1,300 days. The DHS reactor was exposed to shock loadings of organics at double the normal rate for 400 min under summer and winter conditions. The results showed that the DHS reactor maintained stable operation under the organic shock loading and that it returned to a steady state soon after restart, confirming that the reactor was resilient to organic shock loadings.
Repositório institucional: potencializando a visibilidade da produção cientifica do centro de humanidades da UFC
Authors: Silva Lidya Nagylla de Almeida , Almeida Anizia , Oliveira Hanna Sandy de , Farias Gabriela Belmont de 
Published: December 2021

A gestão da informação científica é de suma importância às Instituições de Ensino Superior (IES), pois é neste ambiente que há múltiplas possibilidades de compartilhamento de ideias e desenvolvimento de novos conhecimentos, favorecendo a comunicação científica no âmbito acadêmico. O presente artigo tem por objetivo apresentar as ações desenvolvidas e os desafios vivenciados pelos membros do projeto de extensão intitulado “Repositório Institucional: Preservação da Memória Científica dos Docentes do Centro de Humanidades” da Universidade Federal do Ceará. O procedimento metodológico adotado se caracteriza por ser experimental. Ao decorrer dos cinco meses de funcionamento do projeto, observamos que a grande maioria dos docentes do Centro de Humanidades desconhece a resolução da instituição sobre o depósito da produção científica no repositório institucional, não possuem interatividade com o mesmo e, consequentemente, não arquivam as produções científicas. Em relação às experiências vivenciadas pelos membros do projeto verifica-se que as atividades fazem um elo entre a abordagem teórica de sala e a prática desenvolvida no projeto, permitindo uma reflexão da prática bibliotecária em relação ao gerenciamento de recursos digitais.
Arquitetura dos stands imobiliários: um estudo de tipos
Authors: Macedo Adilson Costa , Araujo Elisangela Marquine de Sousa 
Published: December 2021

Este é um estudo sobre a arquitetura dos estandes construídos no mesmo lugar onde o desenvolvimento imobiliário que representa será implantado. Da análise de um significativo número de projetos resultou um elenco de tipos e classificação conforme a sua finalidade comercial. A investigação centrada na experiência brasileira tomou como referência exemplos de outros países, particularmente quanto aos aspectos programáticos de apoio a seleção do que se considera como tipo. Como um tipo de edificação o estande de venda atual tem sua origem associada aos primeiros pontos de venda de imóveis na cidade de São Paulo, Brasil: local da pesquisa. Neste contexto de diversificação acentuada dos bairros, há uma clara influência de aspectos socioeconômicos e culturais no setor imobiliário que afetam os estandes de vendas. Espera-se que o estudo ora apresentado possa contribuir para a concepção e o projeto de estandes de venda, como edifícios temporários e ser útil para aqueles que trabalham no marketing imobiliárioPalavras-chave: estande imobiliário; arquitetura temporária; mercado imobiliário.
Eryngium billardieri Extract and Fractions Induce Apoptosis in Cancerous Cells
Authors: Asgharian Parina , Tarhriz Vahideh , Hasanbeiglu Samira , Hosseini Kamran , Molavi Ommoleila 
Published: December 2021

Background:
Eryngium is a genus flowering plant in the Umbelliferae family, having pharmacological
properties, such as anti-inflammatory and anti-diabetic. Given the nature of melanoma and breast cancers in recent
years and the fact that the anti-cancer properties of Eryngium billardieri on mentioned cell lines have not been studied,
the present study was conducted to explore these properties.

Objective:
The mechanisms of cytotoxicity and apoptosis of aerial parts of various extracts and fractions of E.
billardieri on cancerous cells and normal cells were investigated.

Methods:
Samples were collected from natural habitats, dried and then extracted by Soxhlet apparatus with solvents of
n-Hex, DCM and methanol, respectively. The cytotoxic effects of the extracts were investigated by the MTT method
on MCF7, B16 and HFF-2 classes for 24 and 48 hours. Flow cytometry was also used to investigate the mechanism of
cytotoxicity, and it has been confirmed by Real-time PCR of p53 and Bax genes as to which comprise the apoptosis
regulatory proteins. Meanwhile, volatile compounds of extracts were identified by the GC-MS method.

Results:
The obtained data showed that the n-Hex extract of E. billardieri on B-16 and MCF7 cell lines and dichromethane
extract on MCF7 cell line had the most significant cytotoxic effect compared to DMSO control (p-value
<0.001). Our finding showed that the mechanism of n-Hex extract with 80% and 100% vlc fractions on B16 induced
apoptotis compared to HFF-2 control cells; moreover, n-Hex extract and 80% vlc fraction on MCF7 were apoptotic.
The major compounds of n-Hex, DCM, and 80% and 100% fractions of n-Hex extract obtained from GC-MS were
non-terpenoid.

Conclusion:
Non-terpenoid compounds of E. billardieri can be responsible for exhibiting the most cytotoxic effects on
MCF7 and B16 cell lines with apoptotic mechanism, and n-Hex extract was found to have the most significant inhibitory
effect on cancerous cells compared to the HFF-2 control cells by employing the mechanism of apoptosis.
Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast
Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds
Authors: Scarim Cauê Benito , Chin Chung Man 
Published: December 2021

:
Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment
of several illnesses, including cancers. In this review article, we have demonstrated various studies involving these
three pharmacophore classes (thiazoles, triazoles, and thiosemicarbazones) in medicinal chemistry over the last decade
(2011-2021) with a focus on MCF-7 adenocarcinoma breast cancer cells. Our objective is to facilitate drug discovery
of novel chemotherapeutic agents by detailing anti-proliferative compounds.
Case Report: Severe SARS-CoV-2 Infection Treated with Remdesivir in a
Patient with ESRD
Authors: Patel Raj H. , Pella Pablo M. , Haider Naeem , Blanco Renato 
Published: December 2021

Background:
The novel coronavirus disease 2019 (COVID-19) has led to a global pandemic
since its emergence from Wuhan, China, in December of 2019. As research continues to evolve,
there is a paucity of reports describing the management and treatment of COVID-19 in patients with
acute kidney failure and end-stage renal disease (ESRD). These patients have increased susceptibility
to developing severe clinical symptoms from SARS-CoV-2 infection due to their underlying comorbidities.
Remdesivir has emerged as a promising antiviral drug against SARS-CoV-2. However, data
regarding the clinical benefits of remdesivir in patients with severe renal impairment is unavailable as
they have been excluded from clinical trials due to the risk of sulfobutylether-β-cyclodextrin (SBECD)
accumulation in patients with eGFR<30 ml/min per 1.73m2.

Case Presentation:
We present the first case of a 47-year-old male with end-stage renal disease who
was successfully treated with remdesivir during hospitalization for acute respiratory distress syndrome
and respiratory failure arising from COVID-19. The worsening clinical progress of the patient despite
intensive care and treatment with intravenous azithromycin therapy led to the decision to utilize remdesivir
after a risk-benefit analysis, despite his eGFR being <15 ml/min per 1.73m2. Although the patient
developed reversible hepatotoxicity, marked improvement of symptoms was observed after the
five-day course of remdesivir was completed.

Conclusion:
Our findings describe the first instance of compassionate use of remdesivir for the treatment
of COVID-19 in the setting of end-stage renal disease, acute respiratory distress syndrome, and
hypoxemic respiratory failure.
Markers of Neuroinflammation in the Serum of Prepubertal Children
with Fetal Alcohol Spectrum Disorders
Authors: Fiore Marco , Petrella Carla , Coriale Giovanna , Rosso Pamela , Fico Elena , Ralli Massimo , Greco Antonio , De Vincentiis Marco , Minni Antonio , Polimeni Antonella , Vitali Mario , Messina Marisa Patrizia , Ferraguti Giampiero , Tarani Francesca , de Persis Simone , Ceccanti Mauro , Tarani Luigi 
Published: December 2021

Background:
Fetal alcohol spectrum disorders (FASD) are the manifestation of the damage
caused by alcohol consumption during pregnancy. Children with fetal alcohol syndrome
(FAS), the extreme FASD manifestation, show both facial dysmorphology and mental retardation.
Alcohol consumed during gestational age prejudices brain development by reducing, among
others, the synthesis and release of neurotrophic factors and neuroinflammatory markers. Alcohol
drinking also induces oxidative stress.

Hypothesis/Objective:
The present study aimed to investigate the potential association between
neurotrophins, neuroinflammation, and oxidative stress in 12 prepubertal male and female FASD
children diagnosed as FAS or partial FAS (pFAS).

Methods:
Accordingly, we analyzed, in the serum, the level of BDNF and NGF and the oxidative
stress, as free oxygen radicals test (FORT) and free oxygen radicals defense (FORD). Moreover,
serum levels of inflammatory mediators (IL-1α, IL-2, IL-6, IL-10, IL-12, MCP-1, TGF-β, and TNF-
α) involved in neuroinflammatory and oxidative processes have been investigated.

Results:
We demonstrated low serum levels of NGF and BDNF in pre-pubertal FASD children
with respect to healthy controls. These changes were associated with higher serum presence of TNF-
α and IL-1α. Quite interestingly, an elevation in the FORD was also found despite normal FORT
levels. Moreover, we found a potentiation of IL-1α, IL-2, IL-10, and IL-1α1 in the analyzed female
compared to male children.

Conclusion:
The present investigation shows an imbalance in the peripheral neuroimmune pathways
that could be used in children as early biomarkers of the deficits observed in FASD.
Conducting Polymers and Photocatalysis: A Mini Review on Selected Conducting
Polymers and Photocatalysts as TiO2 and ZnO
Authors: Turkten Nazli , Karatas Yunus , Bekbolet Miray 
Published: December 2021

:
This work covers a comprehensive mini review of the recent studies on the use of composites
consisting of conducting polymers coupled with photocatalysts. The selected photocatalysts were
TiO2 and ZnO and conducting polymers were polyaniline, polypyrrole and polythiophene. Based on
the reference studies, preparation and characterization methodologies were presented along with reaction
conditions. Assessment of photocatalytic performance of the composites was based on i. light intensity,
band gap energy and effective wavelength region, ii. surface area and initial adsorption, iii.
zeta potential and the pH of point of zero charges (pHzpc), with respect to selected substrate physicochemical
properties. Conclusive remarks covered recommendations for future studies to fulfill the
misconceptions.
Novel Interactive Tool for Breast and Ovarian Cancer Risk Assessment (Bright Pink Assess Your Risk): Development and Usability Study
Authors: Hibler Elizabeth A , Fought Angela J , Kershaw Kiarri N , Molsberry Rebecca , Nowakowski Virginia , Lindner Deborah 
Published: December 2021

Background
The lifetime risk of breast and ovarian cancer is significantly higher among women with genetic susceptibility or a strong family history. However, current risk assessment tools and clinical practices may identify only 10% of asymptomatic carriers of susceptibility genes. Bright Pink developed the Assess Your Risk (AYR) tool to estimate breast and ovarian cancer risk through a user-friendly, informative web-based quiz for risk assessment at the population level.

Objective
This study aims to present the AYR tool, describe AYR users, and present evidence that AYR works as expected by comparing classification using the AYR tool with gold standard genetic testing guidelines.

Methods
The AYR is a recently developed population-level risk assessment tool that includes 26 questions based on the National Comprehensive Cancer Network (NCCN) guidelines and factors from other commonly used risk assessment tools. We included all women who completed the AYR between November 2018 and January 2019, with the exception of self-reported cancer or no knowledge of family history. We compared AYR classifications with those that were independently created using NCCN criteria using measures of validity and the McNemar test.

Results
There were 143,657 AYR completions, and most participants were either at increased or average risk for breast cancer or ovarian cancer (137,315/143,657, 95.59%). Using our estimates of increased and average risk as the gold standard, based on the NCCN guidelines, we estimated the sensitivity and specificity for the AYR algorithm–generated risk categories as 100% and 89.9%, respectively (P<.001). The specificity improved when we considered the additional questions asked by the AYR to define increased risk, which were not examined by the NCCN criteria. By race, ethnicity, and age group; we found that the lowest observed specificity was for the Asian race (85.9%) and the 30 to 39 years age group (87.6%) for the AYR-generated categories compared with the NCCN criteria.

Conclusions
These results demonstrate that Bright Pink’s AYR is an accurate tool for use by the general population to identify women at increased risk of breast and ovarian cancer. We plan to validate the tool longitudinally in future studies, including the impact of race, ethnicity, and age on breast and ovarian cancer risk assessment.