bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrepreneurial intentions among women: does entrepreneurial training and education matters? (Pre- and post-evaluation of psychological attributes and its effects on entrepreneurial intention)
Authors: Bhatti Muhammad Awais , A Al Doghan Mohammed , Mat Saat Suzanie Adina , Juhari Ariff Syah , Alshagawi Mohammed 
Published: February 2021

PurposeResearchers have been trying to identify different psychological attributes which influence entrepreneurial intention (EI) and role of entrepreneurial education and training programs to develop these attributes among women. Therefore, the purpose of this study is twofold: firstly, to evaluate the difference among psychological attributes before and after an entrepreneurial education and training program. Secondly, to examine the effects of psychological attributes on EI among female students in Saudi Arabia.Design/methodology/approachA detailed program was designed with the combination of entrepreneurial education and training program throughout a 14-week semester. Data were collected using a structured questionnaire from 310 female university students studying in a Saudi university and participated in this program. SPSS, version 20, was used to analyze the data.FindingsEntrepreneurial education and training programs based on active learning and learner-centered approaches play an important role to significantly improve the level of psychological attributes and EI of female students. Furthermore, findings of this study also suggest that psychological attributes (training retention, self-confidence, tolerance of ambiguity, innovativeness and achievement motivation) positively influence EI.Originality/valuePrevious studies only focused on relationship testing among psychological attributes and EI. This research proposes strategies to design entrepreneurial education and training program to improve psychological attributes and EI which can be considered practical version of EntreComp conceptual model.
Individual spiritual capital: meaning, a conceptual framework and implications
Authors: Vasconcelos Anselmo Ferreira 
Published: February 2021

PurposeThe purpose of this conceptual paper is to trigger a transcendental concern toward building the spiritual capital (SC) particularly focused on the highly relevant domain of work. In doing so, this conceptual framework focuses on potential antecedents and outcomes of the SC.Design/methodology/approachSuch an endeavor is premised on the Christian's teaching that advocates the need for gathering spiritual treasures (i.e. capital). Secondly, the foray into Spiritism Doctrine (SD) literature is due to the fact that this doctrine considers the spiritual construct as the cornerstone of its principles and tenets. Thirdly, it also examines the related perceptions and approaches from the fields of positive psychology, positive organizational scholarship, workplace spirituality and psychology of religion.FindingsThe model invites the individual to capitalize on salient virtues and remarkable human qualities so as to build a SC, namely: humility, compassion, forgiveness, empathy, positive emotions, connections/relationships and sense of cooperation. Finally, it is envisaged that the attempt to create a SC may lead the individual to a feeling of well-being and more resilience at work.Practical implicationsAt last, the implications to develop a SC in the context of work are sizeable. After all, it implies to add more concerns to one's career much beyond those strictly functional or professional ones. Rather, it means to regard the work domain through unusual lens.Originality/valueBy bringing the conceptual framework of SC to the forefront of management, spirituality and religion studies through an interdisciplinary approach showed that it is not an elusive or mythical topic. On the contrary, this analysis revealed that this is a serious and surprisingly neglected issue that deserves further attention in light of the benefits that it can potentially yield.
The asymmetric online talk effect
Authors: Zhang Ying , Lu Xing , Prombutr Wikrom 
Published: February 2021

PurposeThe authors investigate the extent to which online talk can influence contemporaneous and future stock trading, especially when market news is unpresented.Design/methodology/approachThe authors propose an improved sentiment formula incorporating online hype, neutral sentiment and poster reputation. In addition, they conduct event study, OLS regression analyses and probit models.FindingsFirst, investors tend to be more talkative in relation to firms that are (1) smaller size, (2) more growth-like, (3) with lower prices and higher short interests and (4) of higher beta. Second, the bullish tone of investors positively affects the abnormal returns of small-capitalization stocks. However, online talk has little impact on large-capitalization stocks, except that more postings boost trading liquidity. Third, online talk predicts the presence of future news regardless of firm size, with stronger predictive power found for small-capitalization stocks.Practical implicationsIt is of interest to practitioners and researchers to study online talk so as to better understand the trading psychology of retail investors and the effects on the stock market. Furthermore, policymakers are interested in tracking activities on stock message boards in order to prevent security fraud and protect investors' interests.Originality/valueThe results are robust and suggest that online talk has significant impacts on stock trading exploiting an information asymmetry. This study of stock message board posting activities helps researchers to understand whether message contents contain valuable and unique content compared with information available via more traditional media channels.
A framework for confronting a pivotal change challenge
Authors: Komlos David , Benjamin David 
Published: February 2021

Purpose
When confronted by high-stakes challenges that require a change of course leaders need fast, high-quality decisions and genuine team alignment on the path forward. To address this problem, we offer an experience-tested framework for confronting defining moments of high complexity, low clarity and weak alignment.

Design/methodology/approach
The framework is based on four key principles: a unifying goal, a requisite variety of people, a group-wide communication network that connects everyone on the team, repeated, high-quality collision.

Findings
Collisions among knowledgeable team members are what produce a solution and buy-in. They are what surfaces relevant understanding about how potential actions are connected.

Practical implications
For effective teams, identify those directly affected by the challenge, those with relevant experiences or specialist know-how and those who will ultimately own and execute solutions.

Originality/value
This step-by-step process guide will be useful to leaders needing to course correct while trying to digitize, merge, turn around, grow, deliver a leading-edge customer experience or during a myriad of other complex pursuits. The high-stakes nature of these challenges becomes apparent when leaders realize that their team’s current course and speed is not going to deliver the needed results and intended impact soon enough or, worse, not at all.
Evaluation of bend curvature of superheater tube using CFD analysis
Authors: Chatterjee Sushovan , Das Subhasish , Sarma Neelam Kumar 
Published: February 2021

Purpose
The heat transfer within a heat exchanger is highly influenced by geometry of the components especially those with hollow structures like tubes. This paper aims to intend toward the study of efficient and optimized heat transfer in the bends of superheater tubes, with different curvature ratio at constant Reynolds Number.

Design/methodology/approach
The effect of changing curvature ratio on enthalpy of the fluid passing through the superheater tubes for multi-pass system has been studied with the aid of computational fluid dynamics (CFD) using ANSYS 14.0. Initially a superheater tube with two pass system has been examined with different curvature ratios of 1.425, 1.56, 1.71, 1.85 and 1.99. An industry specified curvature ratio of 1.71 with two pass is investigated, and a comparative assessment has been carried out. This is intended toward obtaining an optimized radius of curvature of the bend for enhancement of heat transfer.

Findings
The results obtained from software simulation revealed that the curvature ratio of 1.85 provides maximum heat transfer to the fluid flowing through the tube with two pass. This result has been found to be consistent with higher number of passes as well. The effect of secondary flow in bends of curvature has also been illustrated in the present work.

Research limitations/implications
The study of heat transfer in thermodynamic systems is a never-ending process and has to be continued for the upliftment of power plant performances. This study has been conducted on steady flow behavior of the fluid which may be upgraded by carrying out the same in transient mode. The impact of different curvature ratios on some important parameters such as heat transfer coefficients will certainly upgrade the value of research.

Originality/value
This computational study provided comprehensive information on fluid flow behavior and its effect on heat transfer in bends of curvature of superheater tubes inside the boiler. It also provides information on optimized bend of curvature for efficient heat transfer process.
Clophosome alleviate dextran sulphate sodium‐induced colitis by regulating gut immune responses and maintaining intestinal integrity in mice
Authors: Tian Wen‐jie , Wang Qian‐nan , Wang Xue‐feng , Dong Dan‐feng 
Published: February 2021

AbstractInflammatory bowel disease (IBD) is a chronic progressive disorder characterized by complicated gastrointestinal inflammation. Research on therapeutic agents is still urgent due to the lack of satisfactory treatments. Gut macrophages are considered to be predominant in excessive inflammatory responses. Thus, we aimed to investigate whether depletion of macrophages would have a beneficial effect on IBD and could be a potential therapeutic strategy. In this study, we established a 12‐day Dextran sodium sulphate (DSS)‐induced colitis mouse model and determined the effect of the macrophage depletion agent Clophosome (neutral clodronate liposomes; CNC). The results showed that CNC significantly alleviated the symptoms of colitis, as demonstrated by greater weight gain, decreased disease activity index (DAI) scores, and lower histopathological damage scores, as well was reduced levels of the proinflammatory cytokines interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α. To investigate T cell subsets, cells were isolated from the lamina propria and cultured to analyse the expression of IL‐17A, interferon (IFN)‐γ and Foxp3 in CD4+ cells by flow cytometry. The data showed that during the process of colitis, the frequencies of CD4+IL‐17A+ T cells were significantly increased. Notably, CNC treatment markedly reduced the population of CD4+IL‐17A+ T cells, especially CD4+IL‐17A+IFN‐γ+ T cells. Furthermore, intestinal barrier integrity, as assessed by immunostaining of mucin and tight junction proteins, was severely disrupted in colitis. CNC improved the intestinal barrier by enhancing the expression of muc‐2 and occludin. In summary, our findings demonstrated that CNC successfully ameliorated DSS‐induced colitis and that its effect may be associated with inhibiting inflammatory responses and maintaining intestinal integrity.
Clinical profile, treatment and outcome of Kawasaki disease: A single‐center experience from a tertiary care referral center of Assam, north‐east India
Authors: Sharma Dhrubajyoti , Iqbal Farhin , Narayan Dev Chiranjeet , Bora Shivangi , Hoque Ruhul Amin , Kom Leivon Bellamy 
Published: February 2021

AbstractAimThis is a retrospective study to report our experience with a cohort of 73 patients with Kawasaki disease (KD) over 2.5 years.MethodThe study was conducted in the Department of Pediatrics. Data were retrieved from medical records of Pediatric Rheumatology and Immunodeficiency Clinic collected from April 2017 to October 2019 and analyzed.ResultsMale‐to‐female ratio in our cohort was 2:1. The median age at diagnosis of KD was 3 years (IQR, 4.25). Fever was present in all patients. Oral mucosal changes are the second most common symptom (N = 64, 87%) followed by extremity changes (N = 58, 79%), and rash (N = 56, 76%). Nineteen (26%) children had cardiovascular complications like coronary artery abnormalities (N = 15, 20%), cardiac tamponade (N = 2, 2%), and shock (N = 1, 1%). The effusion in the patients with cardiac tamponade contained inflammatory cells and plenty of red blood cells. Sixty‐eight (93%) patients with KD had received treatment with IVIg. Patients in our cohort had completed a mean follow‐up of 13.6 ± 9.4 months. No fatality or any long term adverse effects were observed on follow‐up.ConclusionKawasaki disease is a common rheumatological disorder in children at our center with diverse clinical presentations. The disease needs to be considered as a differential diagnosis in an acute febrile illness in children persisting up to 5 days.
Assessment of the anti‐rheumatoid arthritis activity of Gastrodia elata (tian‐ma) and Radix aconitic lateralis preparata (fu‐zi) via network pharmacology and untargeted metabolomics analyses
Authors: Yang Jie , Zhang Yu , Li Wei‐Hong , Guo Bu‐Fa , Peng Qi‐Lun , Yao Wei‐Yi , Gong Di‐Hong , Ding Wei‐Jun 
Published: February 2021

AbstractAimGastrodia elata and Radix aconiti lateralis preparrata are respectively named as Tian‐Ma and Fu‐Zi (TF) in Chinese. We explored the active components against rheumatoid arthritis (RA) from an extensively used couplet of Chinese herbs, Gastrodia elata and Radix aconiti lateralis preparata (TF) via untargeted metabolomics and network pharmacological approaches.MethodsWater extracts of TF were mixed at ratios 1:1, 3:2 and 2:3 (w/w). Ultra‐performance liquid chromatography/tandem mass spectrometry (UPLC‐MS/MS) was then utilized as metabolomics screening. Human Metabolome (http://www.hmdb.ca/) and Lipidmaps (http://www.lipidmaps.org/) databases were used to annotate detected compounds. Further identification of vital genes and important pathways associated with the anti‐RA properties of the TF preparations was done via network pharmacology, and verified by real‐time quantitative polymerase chain reaction (RT‐qPCR).ResultsFour key compounds involved in unsaturated fatty acid biosynthesis and isoflavonoid biosynthesis were identified through metabolomics analyses. Three key components of TF associated with anti‐RA activity were linoleic acid, daidzein, and daidzin. Results of RT‐qPCR revealed that all 3 tested TF couplets (1:1, 3:2, and 2:3) markedly suppressed the transcription of PTGS2. These results were consistent with our network pharmacological predictions.ConclusionsThe anti‐RA properties of Tian‐Ma and Fu‐Zi are associated with the inhibition of arachidonic acid metabolism pathway.
Clinical assessment of cemento‐osseous dysplasia based on three‐dimensional diagnostic imaging: A case report
Authors: Shibata Naoki , Inamoto Kyoko , Naitoh Munetaka , Ariji Eiichiro 
Published: February 2021

AbstractCemento‐osseous dysplasia (COD) is a lesion in which periapical bone is replaced by fibrous tissue, including osseous or cementum‐like tissue. In the initial stage of COD, radiolucencies are noted at the root apex on periapical radiography, which can be confused with apical periodontitis. Understanding of correct pathological condition and careful assessment of COD is critical to avoid unnecessary endodontic interventions in healthy teeth. This report describes the ability and usefulness of cone‐beam computed tomography (CBCT) and multi‐slice computed tomography (MSCT) to detect COD. The findings in this case suggest that MSCT is more appropriate than CBCT, especially for patients with early‐ to middle‐stage COD. However, the radiation dose is higher in MSCT than in CBCT; the application of MSCT should be limited to assessment of whether treatment or surgical management is necessary.
Gastrin and somatostatin enteroendocrine cells in the small intestines of ostrich (Struthio camelus var. domesticus) during pre ‐and post‐hatching period
Authors: Dūrītis Ilmārs , Hussar Piret , Mugurēvičs Arnis 
Published: February 2021

AbstractStudies on localization and distribution of enteroendocrine cells (EECs) are important for better understanding of their role in the ontogenetic development of intestines. Information about the distribution of the most important endocrine cells in the digestive tract of the ostrich is very limited; therefore, the aim of the present study was to identify gastrin and somatostatin EECs in the small intestine of the ostrich (Struthio camelus var. domesticus) chicks at different ages. Six embryos along with 42 ostriches of both sexes from hatching up to 60 days post‐hatching, including six embryos, were obtained from an ostrich farm in Latvia. Duodenum, jejunum and ileum were investigated using routine histology and immunohistochemistry methods. Gastrin and somatostatin EECs were examined in 10 microscopic fields of the intestinal mucosa in each tissue sample. The cells were detected in all age groups as well as the embryos. The number of both types of EEC in the mucosa of the ileum was significantly lower (p < .01–.05) than in the duodenum. The present study suggested that the EEC may have a role in the development of the mucosa of the intestinal tract of ostriches with possible involvement in the development of the digestive functions.
Understanding local government responses to alcohol‐related harm
Authors: Guizzo Miranda , Ward Bernadette , Wilkinson Claire , Vally Hassan , Kuntsche Sandra 
Published: February 2021

AbstractIntroductionLocal governments (LG) have a key role in reducing alcohol‐related harm, yet, Australian research investigating this is limited. This study aimed to explore Australian LGs' role in alcohol policy by investigating how LGs respond to alcohol‐related harm and what influences their responses.MethodsA collective case study approach guided two‐stage purposive sampling. Victorian metropolitan and regional LGs were invited to participate based on alcohol‐related harm profiles. Officers within LGs with alcohol policy knowledge participated in semi‐structured interviews. Transcripts were analysed deductively using a pre‐existing alcohol policy framework and inductively using thematic analysis.ResultsNine officers from eight LGs participated. LG responses to alcohol‐related harm predominately included bans on alcohol in public spaces, licensed premises planning and alcohol‐free youth events. Half implemented liquor forums/accords and most implemented education programs in sporting clubs, schools or workplaces. In some LGs, the reduction of alcohol‐related harm was not considered a priority. Key influences on alcohol initiatives were legislation, the composition of licensed venues, extent of alcohol‐related harms, resources and priorities, and stakeholder feedback.Discussion and ConclusionsWhile particular policies were widespread, participating LGs varied greatly in activity in, and responses to, reducing alcohol‐related harm. LGs reported varied influences on their responses. LGs recognised the long‐term health harms of alcohol in their health planning documents, however, most prioritised interventions targeting short‐term amenity and safety harms. Changes to Victorian planning and liquor licensing legislation to give additional powers to LGs and providing pre‐developed alcohol programs with dedicated funding should be considered.
The long and winding road to target protein misfolding in cardiovascular diseases
Authors: Diteepeng Thamonwan , del Monte Federica , Luciani Marco 
Published: February 2021

AbstractBackgroundIn the last decades, cardiovascular diseases (CVD) have remained the first leading cause of mortality and morbidity in the world. Although several therapeutic approaches have been introduced in the past, the development of novel treatments remains an important research goal, which is hampered by the lack of understanding of key mechanisms and targets. Emerging evidences in recent years indicate the involvement of misfolded proteins aggregation and the derailment of protein quality control in the pathogenesis of cardiovascular diseases. Several potential interventions targeting protein quality control have been translated from the bench to the bedside to effectively employ the misfolded proteins as promising therapeutic targets for cardiac diseases, but with trivial results.DesignIn this review, we describe the recent progresses in preclinical and clinical studies of protein misfolding and compromised protein quality control by selecting and reporting studies focusing on cardiovascular diseases including cardiomyopathies, cardiac amyloidosis, atherosclerosis, atrial fibrillation and thrombosis.ResultsIn preclinical models, modulators of several molecular targets (eg heat shock proteins, unfolded protein response, ubiquitin protein system, autophagy and histone deacetylases) have been tested in various conditions with promising results although lacking an adequate transition towards clinical setting.ConclusionsAt present, no therapeutic strategies have been reported to attenuate proteotoxicity in patients with CVD due to a lack of specific biomarkers for pinpointing upstream events in protein folding defects at a subclinical stage of the diseases requiring an intensive collaboration between basic scientists and clinicians.
High preharvest donor Foxp3 mRNA level predicts late relapse of acute lymphoblastic leukaemia after haematopoietic stem cell transplantation
Authors: Jacobsen Niels , Frisch Tina , Keiding Niels , Heilmann Carsten , Sengeløv Henrik , Madsen Hans O. , Marquart Hanne , Dickmeiss Ebbe , Andersen Mette K. , Christiansen Claus B. , Ryder Lars P. 
Published: February 2021

AbstractObjectivesThe curative effect of allogeneic haematopoietic stem cell transplantation (HSCT) for acute leukaemia is due in part to the donor T cell–mediated graft‐versus‐leukaemia immune reaction (GvL). Several studies have suggested that donor CD25+CD4+Foxp3+regulator T cells (Tregs) may decrease graft‐versus‐host disease (GvHD) without abrogating GVL. This notion may need modification in acute lymphoblastic leukaemia (ALL).MethodsFoxp3 mRNA level was measured by qPCR in preharvest donor blood CD4+ T cells. The study comprised 45 patients with ALL in 1st or 2nd CR who received myeloablative HSCT using T‐replete bone marrow grafts.ResultsRelapse occurred in 17 patients median 363 days after HSCT. The relapse risk was estimated by Cox univariate and multivariate proportional hazard regression. The proportionality assumption was met by analysing the preharvest donor Foxp3 mRNA level as a time‐dependent covariate. Early relapse was not modified by the Foxp3 mRNA level. However, a higher Foxp3 mRNA level was associated with a significantly increased relapse risk after day 363 after transplantation, compatible with inhibition of GvL. In contrast, a higher preharvest donor CD4+ T‐cell concentration was associated with reduced relapse risk.ConclusionA higher preharvest donor Foxp3 mRNA level may be predictive of late ALL relapse after HSCT.