bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management strategies for patients with subclinical hypothyroidism: a protocol for an umbrella review
Authors: Bauer Brenda S. , Azcoaga-Lorenzo Amaya , Agrawal Utkarsh , McCowan Colin 
Published: November 2021

Abstract
Background
Subclinical hypothyroidism is a thyroid disorder diagnosed from the laboratory blood test results of otherwise asymptomatic patients. It has been associated with poor cardiovascular outcomes, mortality and progression to overt thyroid hormone deficiency. Current guidelines on the management of subclinical hypothyroidism differ because of conflicting evidence on long-term treatment benefits. Even though there are several existing systematic reviews on its clinical outcomes, no definitive conclusion has been reached yet. As such, a new synthesis could help provide more insight and consensus on this topic. To this purpose, this umbrella review will evaluate and synthesise current evidence on the long-term clinical outcomes of the different management strategies for subclinical hypothyroidism.

Methods
This is a protocol for an umbrella review on the management strategies for subclinical hypothyroidism. We will conduct literature searches in multiple electronic databases (from inception onwards), namely MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Database of Systematic Reviews, JBI Evidence Synthesis, Epistemonikos database, PDQ Evidence and the PROSPERO register. There will be no restriction on the date or language of publication. Additional material will be identified through grey literature searches and citation chaining. Review inclusion criteria will be patients with subclinical hypothyroidism, receiving treatment or monitoring, no restrictions on the comparators used and with cardiovascular events, frailty fractures, quality of life and all-cause mortality as primary outcomes of interest. Two reviewers will independently screen all citations, full-text articles and abstract data on a pre-piloted form in duplicate. Methodological quality (or bias) of included studies will be appraised using AMSTAR-2. Any conflicts that arise will be resolved through discussion or involving a third reviewer. A narrative synthesis will be provided with information presented in the main text and tables to summarise and explain the characteristics and findings of the included reviews. Even so, it is not expected that a meta-analysis will be performed due to review variability. Study limitations and methodological quality assessments will also be reported to provide context for the overall summary of evidence.

Discussion
This review will provide a comprehensive summary of the effects of the pharmacological and non-pharmacological management of subclinical hypothyroidism on specific long-term clinical outcomes. It is anticipated that the findings of this umbrella review will aid in the development of consensus-based clinical recommendations for subclinical hypothyroidism, as well as highlight areas for future research. Review findings will be disseminated primarily through peer-reviewed publications.

Systematic review registration
PROSPERO CRD42021235172
Compact operators on sequence spaces associated with the Copson matrix of order α
Authors: Mursaleen M. , Edely Osama H. H. 
Published: October 2021

AbstractIn this work, we study characterizations of some matrix classes $(\mathcal{C}^{(\alpha )}(\ell ^{p}),\ell ^{\infty })$
(

C

(
α
)

(

ℓ
p

)
,

ℓ
∞

)
, $(\mathcal{C}^{(\alpha )}(\ell ^{p}),c)$
(

C

(
α
)

(

ℓ
p

)
,
c
)
, and $(\mathcal{C}^{(\alpha )}(\ell ^{p}),c^{0})$
(

C

(
α
)

(

ℓ
p

)
,

c
0

)
, where $\mathcal{C}^{(\alpha )}(\ell ^{p})$

C

(
α
)

(

ℓ
p

)
is the domain of Copson matrix of order α in the space $\ell ^{p}$

ℓ
p

($0< p<1$
0
<
p
<
1
). Further, we apply the Hausdorff measures of noncompactness to characterize compact operators associated with these matrices.
An improved fast iterative shrinkage thresholding algorithm with an error for image deblurring problem
Authors: Tianchai Pattanapong 
Published: November 2021

AbstractIn this paper, we introduce a new iterative forward-backward splitting method with an error for solving the variational inclusion problem of the sum of two monotone operators in real Hilbert spaces. We suggest and analyze this method under some mild appropriate conditions imposed on the parameters such that another strong convergence theorem for these problem is obtained. We also apply our main result to improve the fast iterative shrinkage thresholding algorithm (IFISTA) with an error for solving the image deblurring problem. Finally, we provide numerical experiments to illustrate the convergence behavior and show the effectiveness of the sequence constructed by the inertial technique to the fast processing with high performance and the fast convergence with good performance of IFISTA.
The virtual COVID-19 classroom: surveying outcomes, individual differences, and technology use in college students
Authors: Sage Kara , Jackson Sophia , Fox Emily , Mauer Larissa 
Published: November 2021

AbstractThe COVID-19 pandemic caused many colleges to quickly shift to virtual learning, leading students to rely on technology to complete coursework while also experiencing new situations and stressors. The present study explored students’ technology use in their online course in conjunction with several student outcomes and individual difference measures. Ninety-six undergraduate students were surveyed about devices used and their perceptions of those devices. In addition, the survey measured students’ engagement, motivation, procrastination, perceived stress, and self-efficacy. It also asked students to report their current grade as well as how satisfied and isolated they felt in their course. Relationships emerged in predictable ways between course outcomes and individual difference measures. And though laptops were most used for coursework, more smartphone use related to lower feelings of isolation. Lower feelings of isolation then related to higher grades and less stress. Regression analyses confirmed that smartphone use explained unique variance in feelings of isolation, and further revealed that perceived stress consistently predicted all outcomes. From these results and complementary qualitative survey data, it seems that both laptops and smartphones hold importance for academics in the current context. Educators should further explore the role of device in students’ experience as well as consider this information when designing online courses.
Consumption of Milk and alternatives decreased among Canadians from 2004 to 2015: evidence from the Canadian community health surveys
Authors: Vatanparast Hassan , Islam Naorin , Shafiee Mojtaba 
Published: November 2021

Abstract
Background
Milk and milk products make important contributions to the diet of Canadians. The aim of this study was to examine trends in Milk & Alternatives consumption among Canadians (≥2 years) from 2004 to 2015.

Methods
We used nutrition data from 2 nationally representative cross-sectional surveys conducted in 2004 and 2015 [Canadian Community Health Survey (CCHS) 2004 Cycle 2.2 and CCHS-Nutrition 2015] to compare Milk & Alternatives consumption between 2004 and 2015. Data from 24-h dietary recalls were collected using the Automated Multiple-Pass Method (AMPM).

Result
From 2004 to 2015, the proportion of Canadians consuming Milk & Alternatives food group significantly decreased from 89.5 to 87.7% and the number of servings consumed per day dropped from 1.9 to 1.7. Despite their low energy contribution (12.3% of energy), Milk & Alternatives contributed 45.8% of calcium, 39.9% of vitamin D, and 36.0% of vitamin B12 to the diet of the Canadian population in 2015. Milk & Alternatives were among the top sources of vitamin A, phosphorus and riboflavin. Milk & Alternatives food group was a major contributor to saturated fat intake in both 2004 (31.2%) and 2015 (28.6%). In 2015, dietary intakes of calcium and vitamin D among Milk & Alternatives consumers were 137.8, and 59.4% higher, respectively, than those of non-consumers.

Conclusion
Daily intake of Milk & Alternatives has decreased in the Canadian population over time, which may adversely affect the nutritional profile of the diet.
A case of uterine inclusion cysts in a sow
Authors: Ruiz-Riera Elisa , Nofrarias Miquel , Martí-Garcia Bernat , Domingo Mariano , Segalés Joaquim , Vidal Enric 
Published: November 2021

Abstract
Background
Serosal inclusion cysts are thin walled-structures located on the peritoneal surface of the uterus, frequently observed as multiple cystic structures in aggregates or grape-like clusters containing a clear, non-viscous fluid. In human and veterinary medicine, they are thought to be developed under hormonal effects, or after manipulation or inflammation of the reproductive tract. However, they have not yet been described in swine.

Case presentation
A uterus of a 3-year-old crossbreed sow was condemned at slaughter due to the presence of multiples cystic cavities attached to the serosal surface. Microscopically, multiple cystic dilations emerging from the serosa were lined by a simple and flattened epithelium (cytokeratine positive and vimentin negative on immunohistochemistry) supported by a subepithelial layer of collagen. Grossly and histologically, they were diagnosed as serosal inclusion cysts.

Conclusion
To the authors’ knowledge, this report represents the first description of serosal inclusion cysts in sows. These lesions should be taken into consideration within the differential diagnostic list of cystic peritoneal lesions such as cystic neoplasms, congenital cysts, and parasitic diseases.
Serial urinary neutrophil gelatinase associated lipocalin in pediatric diabetic ketoacidosis with acute kidney injury
Authors: Williams Vijai , Jayashree Muralidharan , Nallasamy Karthi , Dayal Devi , Rawat Amit , Attri Savita Verma 
Published: November 2021

Abstract
Background
Acute kidney injury (AKI) due to Diabetic Ketoacidosis (DKA) is rather common. Novel biomarkers to diagnose AKI are being increasingly used in different settings. The use of urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in predicting persistent AKI in pediatric DKA cases is still not thoroughly investigated.

Methods
This was a secondary analysis of Saline versus Plasma-Lyte in Ketoacidosis (SPinK) trial data; 66 children (> 1 month-12 years) with DKA, defined by the International Society for Pediatric and Adolescent Diabetes (ISPAD), were analyzed. Children with cerebral edema, chronic kidney disease and those who received pre-referral fluids and/or insulin were excluded. uNGAL and urine NGAL-creatinine ratio (uNCR) at 0 and 24 h were measured in all. Persistent AKI was defined as a composite outcome of continuance of AKI defined by the Kidney Disease Improving Global Outcomes (KDIGO) stage 2 or 3 beyond 48 h from AKI onset, progression of AKI from either KDIGO stage 0 or 1 to a worse stage, need of renal replacement therapy or death.

Main outcomes
Thirty-five (53%) children had AKI at admission; 32 (91.4%) resolved within 48 h. uNGAL was significantly higher in the AKI group at admission [79.8 ± 27.2 vs 54.6 ± 22.0, p = 0.0002] and at 24 h [61.4 ± 28.3 vs 20.2 ± 14.5, p = 0.0003]. Similar trend was observed with uNCR at admission [6.7 ± 3.7 vs 4.1 ± 2.6, p = 0.002] and at 24 h [6.3 ± 2.5 vs 1.2 ± 1.0, p = 0.01]. Furthermore, uNGAL at admission showed a moderate positive linear correlation with serum creatinine. Additionally, elevated uNGAL at 0 and 24 h correlated with corresponding KDIGO stages. Admission uNGAL >88 ng/ml and uNCR of >11.3 ng/mg had a sensitivity of 66% and 67%, specificity of 76% and 95%, and Area under the receiver operating characteristic curve (AUC) of 0.78 and 0.89 respectively for predicting persistent AKI at 48 h.

Conclusions
Majority of AKI resolved with fluid therapy. While uNGAL and uNCR both correlated with serum creatinine and AKI stages, serial uNCR was a better predictor of persistent AKI than uNGAL alone. However, feasibility of routine uNGAL measurement to predict persistent AKI in DKA needs further elucidation.

Trial registration
This was a secondary analysis of the data of SPinK trial [CTRI/2018/05/014042 (ctri.nic.in)].
Conspecific neighbors and kinship influence egg cannibalism in the green lacewing, Chrysoperla carnea (Stephens)
Authors: Sohail Mubasshir , Soomro Qadeer Ahmed , Asif Muhammad Usman , Rauf Imran , Muhammad Raza 
Published: November 2021

Abstract
Background
Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) is an illustrious predator that performs cannibalism upon facing small and defenseless conspecifics. Eating preference of C. carnea larvae was investigated between conspecific and host (Sitotroga cerealella) eggs. Early instars of C. carnea express significant preference toward conspecific eggs over host eggs. Experiments were carried out to examine the role of conspecific neighbors in execution of cannibalistic decision. These cannibalistic behaviors of larvae were also investigated through locomotion bioassays using the video tracking software ANY-maze®.

Results
Larvae commit low egg cannibalism when alone but express higher cannibalism in the presence of conspecific larvae in the neighborhood. The role of relatedness in egg cannibalism was investigated when larvae were offered a choice between conspecific eggs from related and unrelated parents. Larvae did a discrimination between eggs of their own parents and those of other parents.

Conclusion
Behavioral bioassays showed attraction toward conspecific eggs and the eggs of unrelated parents. This study emphasizes the significance of informational and descriptive cues that modulate the cannibalistic expression in C. carnea.
Updates in biomaterials of bearing surfaces in total hip arthroplasty
Authors: Khalifa Ahmed A. , Bakr Hatem M. 
Published: November 2021

AbstractTotal hip arthroplasty (THA) is one of the most successful surgical procedures. It entails replacement of the damaged or diseased joint surface with artificial materials. Various materials had been developed and used to achieve optimal outcomes, including longer survivorship and minimal complications. The primary materials used in the manufacture of THA implants are polymers, metal alloys, and ceramics. The failures of THA mainly result from aseptic loosening due to the production of wear particles and the development of periprosthetic joint injection. A lot of advancement and introduction of new biomaterials in THA implants’ armamentarium are designed to avoid the common failure mechanisms and improve the longevity of the implants. In this review, we discussed various aspects of commonly used biomaterials in THA implants, to provide some updated information.
An empirical analysis of African trade blocs effects on the global economy: new evidence from the gravity model
Authors: Olayungbo David Oluseun , Iqbal Badar Alam 
Published: November 2021

AbstractThis study employs the gravity model to estimate the extent of the contribution of six African trade blocs to the global economy using the gravity model spanning from 1980 to 2018. The gravity equation that models the export contributions of the six selected African RECs to the global export is estimated. The estimated gravity model reveals that the long run estimations show that the coefficient estimate for SACU and ECCAS are insignificant in the long run while SACU, EAC and ECCAS as RECs, have insignificant contribution to export in the short run. Our findings, after establishing cointegration, on the other hand show that COMESA has the highest contribution to the global exports, followed by EAC, ECOWAS and SADC with ECCAS and SACU the lowest contributors. The highest contribution of COMESA followed by EAC may be due to the growing economy of member countries like Kenya and Rwanda, while that of COMESA and SADC may be as a result of the large economy of Nigeria and South Africa respectively. This study concludes that African countries are emerging with great export potentials, therefore, governments and private sectors should create the necessary incentives and export policies for the realization of these potentials to maximise the global value chain.
NPAs and profitability in Indian banks: an empirical analysis
Authors: Das Santosh Kumar , Uppal Khushboo 
Published: November 2021

AbstractAs financial intermediaries, the commercial banks to a large extent depend on the performance of their lending as a critical source of earning. Due to increasing loan failures, the share of non-performing advances has increased substantially in recent years, thereby adversely impacting their profitability. The paper has examined the NPAs and profitability relationship by estimating the determinants of profitability of 39 public sector and private banks for the time period from 2005 to 2019. Using a set of bank specific and macroeconomic predictors of profitability, we found that NPA has negative impact on the rate of profit of the Indian banks. The study suggests that the banks must reduce their NPAs and operating cost to improve their profitability.
The role of financial behaviour, financial literacy, and financial stress in explaining the financial well-being of B40 group in Malaysia
Authors: Rahman Mahfuzur , Isa Che Ruhana , Masud Muhammad Mehedi , Sarker Moniruzzaman , Chowdhury Nazreen T. 
Published: November 2021

AbstractUnderstanding the financial well-being of lower-income group is a critical concern of any government as this group struggles most to meet up with their necessities. Despite the significance, little is known about financial well-being of low-income group. This study attempts to investigate the relationship between financial literacy, financial behaviour, financial stress, and financial well-being of B40 group in Malaysia. A total of 412 usable responses was derived from a survey in Klang Valley and analysed the data following partial least squares structural equation modelling (PLS-SEM) techniques. The results demonstrate that financial behaviour is the key antecedent followed by financial stress and financial literacy in predicting financial well-being. Hence, balancing between income and expenditure, managing financial stress, and increasing financial literacy would be necessary to assure financial well-being of lower-income group people. Governmental and institutional interventions are essential to equip the low-income group people with employment opportunities and financial knowledge to manage their basic living standards.
Is gold a safe haven for the dynamic risk of foreign exchange?
Authors: Wang Kuan-Min , Thi Thanh-Binh Nguyen , Lee Yuan-Ming 
Published: November 2021

AbstractThis paper uses the panel data of 15 countries from 2009 to 2020 to construct the time-varying parameter panel vector error correction model for testing the hypothesis of dynamic hedging characteristics of gold on exchange rate. As the existing literature has never considered that the foreign exchange risk hedged by gold is dynamic, this study can fill the research gap in this area. The empirical results show that: First, gold can partly hedge against the depreciation of the currency in the long run; second, gold is unable to hedge against the risk of the exchange rate when considering dynamic hedging effects in the short run; third, when facing unexpected shocks, the impulse response shows that the gold returns have reversible reactions compared to exchange rate fluctuations; therefore, gold can regard as a safe haven for foreign exchange markets; Finally, the government, as well as investors should always be concerned about these dynamic risks and formulate effective hedging strategies to control the currency uncertainty.
Glucosamine Supplementation Improves Physical Performance in Trained Mice
Authors: DE LA ROSA ADRIAN , OLASO-GONZALEZ GLORIA , GARCIA-DOMINGUEZ ESTHER , MASTALOUDIS ANGELA , HESTER SHELLY N. , WOOD STEVEN M. , GOMEZ-CABRERA MARI CARMEN , VIÑA JOSE 
Published: October 2021

ABSTRACT

Introduction

d-Glucosamine (GlcN) is one of the most widely consumed dietary supplements and complementary medicines in the world and has been traditionally used to attenuate osteoarthritis in humans. GlcN extends life span in different animal models. In humans, its supplementation has been strongly associated with decreased total mortality and improved vascular endothelial function. GlcN acts as a suppressor of inflammation, and by inhibiting glycolysis, it can activate the metabolism of stored fat and mitochondrial respiration.

Methods
The conventional human GlcN dose is 1500 mg·d−1, but extensive evidence indicates that much higher doses are well tolerated. GlcN is one of the supplements that has experienced a greater use in the last years in elite athletes mainly because of its potential chondroprotective effects that may promote cartilage health. However, the possibility of it being an ergogenic aid has not been explored. We aimed to study the potential beneficial effects of GlcN on mitochondrial content, physical performance, and oxidative stress in mice that were aerobically trained and supplemented with three different doses of glucosamine (250, 500, and 1000 mg·kg−1) for 6 wk. We measured exercise performance (grip strength, motor coordination, and running capacity) before and after the training period. Proteins involved in mitochondrial biogenesis (AMPK, PGC-1, NRF-1, SIRT-1, cytochrome c, citrate synthase), markers of oxidative stress (GSSG/GSH) or damage (malondialdehyde, carbonylated proteins), antioxidant enzymes (NRF-2, SOD1, SOD2, catalase, and PRDX6), and MAPKs (p38 and ERK1/2 were also determined in skeletal muscle.

Results and Conclusions
Our results show that GlcN supplementation in aerobically trained mice, at doses equivalent to those conventionally used in humans, increases the protein levels of mitochondrial biogenesis markers, improves motor coordination, and may have a synergistic effect with exercise training on running distance.
Iodine doping of a photocuring, one-component embedding medium for µCT and histology
Authors: Schneider Gerlind , Voigt Sibylle , Alde Alexander , Berg Albrecht , Linde Dirk , Otto Katja , Enkelmann Astrid , Schnabelrauch Matthias 
Published: October 2021

Objective: Evaluation of μCT scans of bone implant complexes often shows a specific problem: if an implant material has a very similar radiopacity as the embedding medium (e.g. methacrylate resin), the implant is not visible in the μCT image. Segmentation is not possible, and especially osseointegration as one of the most important parameter for biocompatibility is not evaluable. Methods: To ensure μCT visualisation and contrast enhancement of the evaluated materials, the embedding medium Technovit® VLC7200 was doped with an iodine monomer for higher radiopacity in different concentrations and tested regarding to handling, polymerisation, and histological preparation, and visualisation in µCT. Six different µCT devices were used and compared with regard to scan conditions, contrast, artefacts, image noise, and spatial resolution for the evaluation of the bone-implant blocks. Results: Visualisation and evaluation of all target structures showed very good results in all μCT scans as well as in histology and histological staining, without negative effects caused by iodine doping. Subsequent evaluation of explants of in vivo experiments without losing important information was possible with iodine doped embedding medium. Conclusion: Visualisation of implants with a similar radiopacity as the embedding medium could be considerably improved. µCT scan settings should be selected with the highest possible resolution, and different implant materials should be scanned individually for optimal segmentation. µCT devices with higher resolutions should be preferred. Advances in knowledge: Iodine doped embedding medium is a useful option to increase radiopacity for better visualisation and evaluation of special target structures in µCT.