bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Hybrid Ensembled Double-Input-Fuzzy-Modules Based Precise Prediction of PV Power Generation
Authors: Zhang Hualu , Shi Jie , Li Wei , Lv Hui 
Published: February 2021

Abstract
BackgroundAs one of the most widespread renewable energy technologies, photovoltaic power generation system provides great environmental and economic benefits. Uncertain output of the photovoltaic power generation system gets a lot of concern, due to its randomicity and intermittence features. Achieving precise prediction for the PV power generation will greatly improve the quality of electric energy and enhance the stability of power system operation. Inspired by the powerful ability of fuzzy logic to deal with uncertainty and the superiority of machine learning to handle the time series prediction, a hybrid ensembled model consisted of the Double-Input-Fuzzy-Modules (DIFM) and Extreme Learning Machine is proposed in this paper. Firstly, the PV power generation data is taken as the input of each DIFM in order to efficiently handle the uncertainties. Then, the outputs of each DIFM are used as the input of ELM. Moreover, the least square estimation is applied to train the parameters of the hybrid ensembled model to further enhance the predict precision. Finally, the proposed hybrid ensembled model is applied to achieve a real-world PV power generation forecasting. ResultsThe case study and comparisons results indicate that the proposed hybrid ensembled model outperforms other methods, including the adaptive network-based fuzzy inference system, the single-input-rule-modules connected fuzzy model, the support vector regression and the multiple linear regression, in terms of the mean absolute error, the root means square error, the mean absolute error percentage and the mean relative error. ConclusionsThis study fully took the advantages of fuzzy logic to deal with uncertainty and the superiority of machine learning to handle the time series prediction, then combined the DIFM and Extreme Learning Machine to propose a hybrid ensembled DIFM based PV power generation prediction model. Experimental results demonstrated the superiorities of the proposed model over the other comparisons, in both prediction accuracy and calculation speed.
Temperature relaxation in strongly-coupled binary ionic mixtures
Authors: Sprenkle Robert , Silvestri Luciano , Murillo M. S. , Bergeson Scott 
Published: February 2021

Abstract
New facilities such as the National Ignition Facility and the Linac Coherent Light Source have pushed the frontiers of high energy-density matter. These facilities offer unprecedented opportunities for exploring extreme states of matter, ranging from cryogenic solid-state systems to hot, dense plasmas, with applications to inertial-confinement fusion and astrophysics. However, significant gaps in our understanding of material properties in these rapidly evolving systems still persist. In particular, non-equilibrium transport properties of strongly-coupled Coulomb systems remain an open question. Here, we study ion-ion temperature relaxation in a binary mixture, exploiting a recently-developed dual-species ultracold neutral plasma. We compare measured relaxation rates with atomistic simulations and a range of popular theories. Our work validates the assumptions and capabilities of the simulations and invalidates theoretical models in this regime. This work illustrates an approach for precision determinations of detailed material properties in Coulomb mixtures across a wide range of conditions.
WITHDRAWN: Heavy Metals in Water and Surface Sediments of the Fenghe River Basin, China: Assessment and Source Analysis
Authors: Luo Pingping , Xu Chengyi , Kang Shuxin , Huo Aidi , Lyu Jiqiang , Zhou Meimei , Nover Daniel 
Published: February 2021

Abstract
This paper combines environmental science, inorganic chemistry, water quality monitoring and other disciplines, and uses several representative evaluation methods (WQI, Pn, I-geo, RI) for heavy metals in water and sediments. A preliminary assessment and source analysis of heavy metals (Cd, Cr, Fe, Mn, Zn, Cr, Ti, Ni, Cu, As, Pb, Sr) in water and surface sediments of the Fenghe River Basin, Shannxi Province, China was carried out in this study. Results indicate that most of the heavy metals in water are below national water quality standards. Exceptions include Mn, which exceeds national tertiary standards and Cr, which exceeds national drinking water standards. Most heavy metals in the sediments exceed the environmental standard values except Ni. Water quality index (WQI) and Nemero index (Pn) showed the same trend in contamination levels of sampling sites. According to the Geological Accumulation Index method (I-geo) and the Potential Ecological Risk Index method (RI), high concentrations of Cd poses a high ecological risk in some sampling locations. Pearson Correlation Analysis (CA), Hierarchical Clustering Analysis (HCA), Principal Component Analysis (PCA) and Positive Matrix Factorization (PMF) models are used to explore the relationships and sources of heavy metals. In general, upstream sources are similar, and middle and lower reaches are easily clustered into a large category except for some specific sampling points. For example, metals in sampling site FHK mainly come from surrounding residents and farms and heavy metals attributes in sampling site SLQ relate to the fact that municipal sewage is collected and treated. The factors or sources of heavy metals in water and sediment are revealed in detail through PMF models. In the water, the average contribution rate of these four source factors for heavy metals is 36.8%, 11.7%, 9.4% and 42.0%, while the average proportion of these four factors for heavy metals in sediment is 8.0%, 29.2%, 23.9% and 38.9% respectively. Results show that the main sources of pollution in the region are urban construction and transportation, electronics industry, machinery manufacturing, tourism and agriculture. These sectors should therefore be given sufficient attention in the prevention and management of heavy metal pollution.
Asymptomatic Urinary Tract Infections and Associated Risk Factors in Pakistani Muslim Type 2 Diabetic Patients
Authors: Aamir Azizul Hasan , Raja Umar Yousuf , Asghar Ali , Mahar Saeed Ahmed , Ghaffar Tahir , Ahmed Ibrar , Qureshi Faisal Masood , Zafar Jamal , Hasan Mohammad Imtiaz , Riaz Amna , Raza Syed Abbas , Khoso Irshad Ahmed , Khan Jahanzeb , Raza Mahwish , Baqar Jaffer Bin 
Published: February 2021

Abstract
Background: One of the leading long-term complications of type 2 diabetes mellitus (T2DM) includes renal dysfunction and urinary tract infections (UTI) which are considered to be prevalent in uncontrolled diabetes. Moreover, physiological factors like age, gender, duration of diabetes, other diabetic complications like neuropathy, autonomic neuropathy and glycosuria are also considered as predisposing factors for increased prevalence of UTI in diabetes which can be symptomatic or asymptomatic. Methods: This was a cross-sectional, multi-centre study including diabetic patients from 12 clinical sites spread across major cities of Pakistan. The inclusion criteria were adult Pakistani population of age between 18 to 75 years both genders and suffering from T2DM irrespective of duration. A detailed clinical history of the past 3 months was recorded and, biochemical investigations of blood samples were conducted. Urine culture analysis performed identified the type of pathogen present and was done only for asymptomatic patients. Results: A total of 745 type 2 diabetic patients were initially screened, out of 545 patients considered for final analysis 501 (91.92%) were negative and the rest 44 (8.08%) had positive urine culture. Female gender had a significantly higher proportion of positive urine culture (77.27%, p-value<0.001). Body mass index and mean age had insignificant distribution among the two groups of positive and negative urine culture, with age 40-59 years having higher proportion (70.45%) in the positive group. Escherichia coli was detected in most of the positive samples (52.3%). All bacterial samples were found resistant to Ciprofloxacin. Conclusion: Diabetic female patients are identified to be at high risk of suffering from UTI and age more than 40 years is an important risk factor. Escherichia coli was the most common causative organism among people living in this geographical area.
The Blood level of Thioredoxin 1 as a Supporting Biomarker in the Detection of Breast Cancer
Authors: Lee Youn Ju , Kim Young , Choi Bo Bae , Kim Je Ryong , Ko Hye Mi , Suh Kyoung Hoon , Lee Jin Sun 
Published: February 2021

Abstract
Background: It has been a long-time unmet need to have a means to detect breast cancer (BC) using blood. Although mammography is accepted as the gold standard for screening, thus, playing a role to reduce death from breast cancer, a blood-based diagnostic can complement mammography and assist in the accurate diagnosis of BC. We have previously reported the possible use of thioredoxin 1 (Trx1) in serum as a novel means to detect BC. In the present study, we validated the clinical utility of Trx1 to detect BC by testing sera from biopsy-confirmed cancer patients, and normal healthy people.Methods: We have generated monoclonal antibodies against Trx1 and developed an ELISA kit that can quantitate Trx1 in sera. The level of Trx1 was determined in each serum from normal healthy women (n=114), as well as patients with BC (n=106), and other types of cancers (n=74) including cervical, lung, stomach, colorectal, and thyroid cancer. The sera from BC patients were collected according to their age and cancer stage. Several pathological and molecular aspects of BC were analyzed along with the Trx1 levels of BC patients. Test results were compared to those from mammography. Each test was duplicated, and test results were analyzed by ROC analysis, one-way ANOVA tests, and unpaired t-tests.Results: The mean level of Trx1 from normal women’s sera was 5.45±4.16 (±SD) U/ml and that from BC was 21.96±6.79 U/ml. The difference between these two values was large enough to distinguish BC sera from healthy sera with a sensitivity of 94.3% and specificity of 94.7% (AUC 0.985, p<0.0001). Most Trx1 levels from BC patients’ sera were higher than the cut-off value of 14.13 Unit/ml regardless of age, stage, histological grade, type, and specific receptors’ expression profile of BC. The blood levels of Trx1 from the group of patients with other types of cancers (2.70±2.01 U/ml) was low to be distinguishable from BC. Trx1 level could rescue most of misreading incompleteness of mammography. Conclusion: These results indicated that the blood level of Trx1 could be an effective and accurate means to assist or complement current BC diagnostic modalities.
Identification of potential biomarkers and therapeutic targets in the chronic obstructive pulmonary disease and acute myocardial infarction
Authors: Chen Fengshou , Hou Haijia , Tang Bing 
Published: February 2021

Abstract
Background

Chronic obstructive pulmonary disease (COPD) and acute myocardial infarction (AMI) have a strong association. We aimed to study the relationships between COPD and AMI, and reveal potential therapeutic targets and biomarkers. ,
Methods

The dataset GSE38974 and GSE60993 were downloaded from the Gene Expression Omnibus (GEO) database to analyze the intersections among differentially expressed genes (DEGs). Common DEGs were identified and performed functional enrichment analyses. The hub genes were obtained based on the protein-protein interaction (PPI) network by cytoHubba in Cytoscape software. The receiver operator characteristic (ROC) curve analysis was applied to identify the diagnosis efficacy of hub genes. The relationship between hub genes and these two diseases in the CTD database were validated. Finally, the transcription factors (TFs) corresponding to hub genes were also analyzed.
Results

In our study, sixty-five common DEGs were obtained in COPD and AMI. GO enrichment analysis indicated that inflammation or apoptotic biological processes are significant enriched biological processes. Common DEGs were mostly enriched in pathways including apoptosis, HIF-1 signaling pathway, TNF signaling pathway, and cytokine-cytokine receptor interaction. MMP9, SOCS3, MCL1, ERBB2 and S100A12 were identified as the hub genes. Furthermore, we found that the expression of hub genes was significantly associated with a diagnosis efficacy of COPD and AMI. We also validated the relationship between the hub genes and these two diseases in the CTD database. We also found that ELK1, ETV4, STAT3 and TFAP2A were significant TFs, which interacted with the hub genes.
Conclusions

In conclusion, our study revealed the communal DEGs and related mechanisms between the pathophysiology of COPD and AMI. MMP9, SOCS3, MCL1, ERBB2 and S100A12 were identified as the hub genes that are associated with COPD and AMI. Our study provides new ideas and evidence for further exploration of the mechanisms and treatment of COPD and AMI.
Correlation of SOX4, SOX17, VE-cadherin and vasculogenic mimicry with prognosis in esophageal squamous cell carcinoma
Authors: Qin Yanzi , Zhao Wenjun , Cai Zhaogeng , Wang Qi , Gao Jin , Ci Hongfei , Feng Zhenzhong , Ma Li 
Published: February 2021

Abstract
Background: This study to explore the relationships between SOX4, SOX17, vascular endothelial (VE)-cadherin and VM with the occurrence and development of ESCC. Methods: SOX4, SOX17, and VE-cadherin expression as well as VM in tissues were determined by immunohistochemistry (IHC). The cell invasion, migration, and proliferation were determined after silencing of VE-cadherin. SOX4, SOX17, and VE-cadherin protein and mRNA expression were quantified by Western blotting and qRT-PCR analyses, respectively.Results: The expression of SOX17, SOX4, and VE-cadherin were significantly correlated with clinical characteristics of ESCC. After VE-cadherin silencing, the cell invasion, migration, and proliferation were decreased, while SOX17 levels were increased and SOX4 levels were decreased.Conclusions: SOX17, SOX4, and VE-cadherin are involved in the development of ESCC.
Long-term Outcomes in Adolescents and Adults with a Cleft Lip and/or palate: Esthetics, Employment and Functioning
Authors: Alighieri Cassandra , D'haeseleer Evelien , Bettens Kim , Bonte Katrien , Vermeersch Hubert , Vermeire Nele , Claeys Merel , Sseremba Daniel , Galiwango George , Lierde Kristiane Van 
Published: February 2021

Abstract
Background. To date, there seems to be no consensus on the long-term quality of life outcomes in patients living with a cleft of the lip and/or palate (CL/P) with regard to well-being and functioning. Some studies report a substantial influence of having a cleft while other studies report no influence of living with a cleft. The purpose of this study was to investigate the impact of living with a CL/P on esthetics, employment and functioning in Dutch-speaking adolescents and adults with a CL/P. Methods. 30 Patients with a CL/P (19 men and 11 women) were included in the study. The mean age of the participants was 26.93 years (SD = 11.688 years, range = 15 – 66 years). An age and gender matched control group was included consisting of 30 participants (19 men and 11 women) without a CL/P with a mean age of 26.87 years (SD = 11.729 years, range = 16-67 years). Esthetics, employment and functioning were assessed using different standardized self-report questionnaires. Results. No statistically significant difference in educational level, employment, monthly net income, marital status and having children was found between participants with and without a CL/P. In addition, the quality of life scores did not differ between the two groups. Within the group of individuals with a CL/P, the findings revealed that the proportion of participants who reported an influence of the CL/P on daily functioning, general well-being, social contacts, family life, applying for a job, work, education and leisure time differed by age. Older individuals experienced more influence of their CL/P compared to younger individuals. With regard to esthetics, the findings revealed that participants without a CL/P were less satisfied with the appearance of their jaws compared to participants with a CL/P. Conclusion. In general, the findings of our study revealed no significant differences between adolescents and adults with and without a CL/P with regard to employment and functioning. Considering age within the group of participants with a CL/P, however, the results demonstrated that older individuals were more likely to experience a negative impact of their cleft on well-being and functioning. These findings suggest that older individuals with a CL/P might benefit from additional socio-emotional support, for example peer contacts and support groups or psychological guidance. Longitudinal research on this topic is highly needed to determine possible fluctuations in the impact of living with a CL/P.
Standardization of Evaluation Method and Prognostic Significance of Histological Response to Preoperative Chemotherapy in High-grade Non-round Cell Soft Tissue Sarcomas: a Report From the Central Pathology Review for the Japan Clinical Oncology Group Study JCOG0304
Authors: Oda Yoshinao , Tanaka Kazuhiro , Hirose Takanori , Hasegawa Tadashi , Hiruta Nobuyuki , Hisaoka Masanori , Yoshimoto Masato , Otsuka Hiroshi , Bekki Hirofumi , Ishii Takeaki , Endo Makoto , Kunisada Toshiyuki , Hiruma Toru , Tsuchiya Hiroyuki , Katagiri Hirohisa , Matsumoto Yoshihiro , Kawai Akira , Nakayama Robert , Kawashima Hiroyuki , Takenaka Satoshi , Emori Makoto , Watanuki Munenori , Yoshida Yukihiro , Okamoto Takeshi , Mizusawa Junki , Fukuda Haruhiko , Ozaki Toshifumi , Iwamoto Yukihide , Nojima Takayuki 
Published: February 2021

Abstract
PurposePreoperative chemotherapy is widely applied to high-grade localized soft tissue sarcomas (STSs); however, the prognostic significance of histological response to chemotherapy remains controversial. This study aimed to standardize evaluation method of histological response to chemotherapy with high agreement score among pathologists, and to establish a cut-off value closely related to prognosis. MethodsUsing data and specimens from the patients who had registered in the Japan Clinical Oncology Group study, JCOG0304, a phase II trial evaluating the efficacy of perioperative chemotherapy with doxorubicin (DOX) and ifosfamide (IFO), we evaluated histological response to preoperative chemotherapy at the central review board.ResultsA total of 64 patients were eligible for this study. The percentage of viable tumor area ranged from 0.1% to 97.0%, with median value of 35.7%. Regarding concordance proportion between pathologists, the weighted kappa coefficient (κ) score in all patients was 0.71, indicating that the established evaluation method achieved substantial agreement score. When the cut-off value of the percentage of the residual tumor area was set as 25%, the p-value for the difference in overall survival showed the minimum value. Hazard ratio of the non-responder with percentage of the residual tumor < 25%, to the responder was 4.029 (95% confidence interval 0.893–18.188, p = 0.070). ConclusionThe standardized evaluation method of pathological response to preoperative chemotherapy showed a substantial agreement in the weighted κ score. The evaluation method established here was useful for estimating of the prognosis in STS patients who were administered perioperative chemotherapy with DOX and IFO.Trial registration﻿UMIN Clinical Trials Registry C000000096. Registered 30 August, 2005 (retrospectively registered).
High-Starch Diet Consumption Impaired Intestinal Barriers of Juvenile Largemouth Bass (Micropterus Salmoides)
Authors: Zhao Liulan , Liang Ji , Liao Lei , Tang Xiaohong , Liu Qiao , He Kuo , Luo Jie , Du Zongjun , Luo Wei , Yang Song 
Published: February 2021

Abstract
The intestinal barrier is primarily composed of physical, physiological and microbial barriers, and intestine microbe-immune interactions influenced by diet in fish still remain increasingly unexplored. The intestinal barriers of Largemouth bass (Micropterus salmoides) (4.1±0.2g) were explored after they were fed three different starch diets for eight weeks (low starch,7%; middle starch, 12%; high starch, 17%). The results showed that high starch diet led slight infiltration of inflammatory cells and moderate loss of mucous membrane layer in midgut. Meanwhile, high starch diet decreased the antioxidant enzymes (T-SOD) activities and genes (SOD1, SOD2, SOD3a, CAT, GPX) expression significantly (P < 0.05). The MDA content was significantly increased with increasing starch level (P < 0.05). High starch diet up-regulated the expression of pro-inflammatory genes (IL-8, IL-1β and TNFα) and apoptosis genes (bax, caspase3, caspase8 and caspase9), whereas down-regulated the expression of anti-apoptosis genes bcl-2 and tight junction proteins genes (occludin and claudin7). In addition, the high starch diet increased the relative abundance of Actinobacteria and Firmicutes, resulted in microbial dysbiosis. In conclusion, high dietary starch impaired intestinal barriers, and increased the risk of disease outbreaks.
Trademark Infringement Recognition Assistance System based on Human Visual Gestalt Psychology and Trademark Design
Authors: Hung Kuo-Ming , Chen Li-Ming , Chen Ting-Wen 
Published: February 2021

Abstract
Trademarks are common graphic signs in human society. People used this kind of graphic sign to distinguish the signs of representative significance such as individuals, organizations, countries, and groups. Under effective use, these graphic signs can bring maintenance and development resources and profits to the owner. In addition to maintenance and development, organizations that have obtained resources can further promote national and social progress. However, the benefits of these resources have also attracted the attention of unfair competitors. By imitating counterfeit trademarks that appear, unfair competitors can steal the resources of the original trademark. In order to prevent such acts of unfair competitors, the state has formulated laws to protect trademarks. In the past, there have also been researches on similar trademark searches to assist in trademark protection. Although the original trademark is protected by national laws, unfair competitors have recently used psychological methods to counterfeit the original trademark and steal its resources. Trademarks counterfeited through psychology have the characteristics of confuse consumers and do not constitute infringement under the law. Under the influence of such counterfeit trademarks, the original trademark is still not well protected. In order to effectively prevent such trademark counterfeiting through psychology, this article proposes new features based on trademark design and Gestalt psychology to assist legal judgments. These features correspond to a part of the process that is not fully understood in the human visual system and quantify them. In the experimental results, we used past cases to analyze the proposed assistance system. Discussions based on past judgments proved that the quantitative results of the proposed system are similar to the plaintiff or the judgment to determine the reasons for plagiarism. This result shows that the assistance system proposed in this article can provide visually effective quantitative data, assist the law to prevent malicious plagiarism on images by unfair competitors, and reduce the plagiarism caused by the similar design concepts of late trademark designers.