bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Endangers the Health of Society by Disrupting Social Participation, Home Integrations, and Productive Activities.
Authors: Monfared Elyas , Vahedi Mohsen , Haghgoo Hojjat Allah 
Published: February 2021

Abstract
ObjectiveProper social participation and involvement in the daily activities of life increases the feeling of attachment, and increases a person's sense of worth, belonging, and dependence on society. Lack of social communication leads to anxiety, loneliness, depression, panic, mental. While COVID-19 has become a pandemic, public health measures to cut off human-to-human transmission may include quarantine and social isolation. Due to social distancing and quarantine practices, people's participation in many areas of social life and daily activities has been disrupted. The purpose of this study is to provide insight into the effects of the Covid 19 epidemic on integration into home activities, integration into the community and integration into productive activities, and overall determination of social participation during this epidemic.MethodsIn June 2020, the Social Integration Questionnaire (CIQ), which measures integration at home, integration in the community, and integration into purposeful and productive activities, was transcribed with the required demographic information in a web-based format. A total of 461 people (mean age 36.86±5.8 years) completed the social integration questionnaire in a cross-sectional study. The effects of Covid-19 on social interaction were then calculated by analyzing CIQ scores before and after the outbreak of COVID-19 and the data were analyzed using SPSS software version 22.ResultsComparing the participants score in the Community Integration Questionnaire before and after the COVID-19 pandemic showed that COVID-19 reduced home integration (from 4.6909±2.84 to 3.5938±2.80 , t= 11.151 p <0.000), social integration (from 8.6529±1.98 to 6.1150±2.10, t= 25.440, p <0.000), integration into productive and purposeful activities (from 5.3145±1.70 to 3.5098±2.02, t= 23.226, p <0.000) and total CIQ test score (from 18.6584±4.02 to 13.2185±4.56 , t= 29.022, p <0.000). These findings show how all three CIQ domains and their total scores decreased significantly after the outbreak of COVID-19.ConclusionAfter the COVID-19 epidemic, people's social life is severely disrupted. The direct and indirect psychological and social effects of COVID- 19 are widespread and can affect mental health. Trial Registration: This study was registered and approved by the Ethic Committee of the University of Social Welfare and Rehabilitation Sciences, Tehran, Iran (IR.USWR.REC.1399.228).
High Mean Arterial Pressure is Associated with Better Cognitive Function in Older Adults with Subjective Memory Complaints
Authors: Fung Ada Wai Tung , Lee Allen Ting Chun , Ma Sukling 
Published: February 2021

Abstract
Background: Hypertension has been shown to be a major risk factor for cognitive decline, but little is known about its association with subjective memory complaints (SMC) in late life. The study is to examine if hypertension is associated with SMC and to explore which blood pressure (BP) is more important in this group.Methods: 497 non-demented older adults aged 60 years or older were interviewed. Hypertension is defined as a BP higher than 130/80 mmHg or on antihypertensive medication. SMC are measured by a validated 5-item Abbreviate Memory Inventory for the Chinese (AMIC) assessing subjective memory deficits in the past month. Cognitive performance was measured by a neurocognitive battery assessing global cognitive function and executive function (EF). Linear regression was performed to examine how different BP associate with AMIC and cognitive performance with adjustment for sociodemographic and physical factors.Results: Hypertensive group had a lower AMIC than normal control (t=-2.1, p=.033). Systolic blood pressure (SBP) (B=-.008, 95% CI -.014 – -.002, p=.006) and mean arterial pressure (MAP) (B=-.011, 95% CI -.020– -.002 p=.014) were associated with AMIC. SBP was only associated global cognitive function (B= .008, 95% CI .000 – .015, p=.038), but MAP was associated with global cognitive function (B=.017, 95% CI .006 – .029, p=.003) and EF (B= 0.16, 95% CI .001 – .030, p=.036). Conclusions: High MAP was associated with better cognitive function in older adults with SMC. The findings highlight the need to be cautious when managing BP in older adults yet not to compromise their current cognitive function.
MiR-182-5p Promotes The Metastasis and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer By Targeting EPAS1
Authors: Yang Wenxiao , Yin Yinan , Bi Ling , Wang Yichao , Xu Ling , Jiao Lijing 
Published: February 2021

Abstract
BackgroundThe dysregulation of microRNAs (miRNAs) is associated with the pathogenesis of non-small cell lung cancer (NSCLC). However, the mechanism underlying miR-182-5p regulation of NSCLC progression is largely unknown. The purpose of this study was to examine the expression levels of miR-182-5p in human NSCLC and its funvtion in lung cancer cells. MethodsThe Cancer Genome Atlas (TCGA) data set was utilized to investigate the association between miR-182-5p expression and the clinicopathological characteristics and prognosis of NSCLC patients. The target genes of miR-182-5p were identified using the prediction tools PITA, miRmap, microT, miRanda, PicTar, and TargetScan. Transwell assays was used to explore the potential function of miR-182-5p in lung cancer cells. Luciferase reporter assay were performed to analyze the regulation of putative target of miR-182-5p and western blot assays were used to validate the luciferase results.ResultsmiR-182-5p was upregulated in NSCLC tissues and acted as an independent prognostic factor of tumor recurrence in NSCLC patients. Functionally, overexpression of miR-182-5p promoted lung cancer cell migration and invasion. Genome-wide gene expression analysis and luciferase report assay revealed that Endothelial PAS Domain-containing protein 1 (EPAS1) was a direct target of miR-182-5p. EPAS1 exhibited a negative correlation with miR-182-5p expression in NSCLC tissues. Univariate and multivariate survival analysis identified EPAS1 as an independent prognostic factor for overall survival and tumor recurrence in NSCLCConclusionsThese findings demonstrate that miR-182-5p functions as a tumor promoter in NSCLC progression by targeting EPAS1. It is, therefore, a potential indicator of tumor recurrence in NSCLC patients.
A Novel Design of Electro-Hydraulic Driven Active Powered Ankle-Foot Prosthesis
Authors: Huang Qitao , Li Bowen , Jia Fei 
Published: February 2021

Abstract
This paper presents the design and control of a novel full active powered ankle prosthesis driven by electro-hydrostatic actuator (EHA) to improve amputee gait during the level-ground walking in full-time gait cycle. A 100W brushless DC motor driving a 0.92 cc/rev bi-directional gear pump serves as the power kernel. An elastic element is configured in series with the hydraulic cylinder. With this architecture, better power characteristic, ability of energy storage and passive compliance are obtained to revive sound human characteristic as much as possible. To smooth the gait pattern, a neuromuscular model with Hill-type muscle tendon structure is introduced into the control system scheduled by finite state machine which was designed to carry on different control strategy during individual gait phase.
Malaria Data Analysis Using Routine Surveillance Data, Sunyani Municipality, Ghana, 2020
Authors: Mohammed Abdul Gafaru , Tamal Christopher Sunkwa , Odikro Magdalene Akos , Bandoh Delia Akosua , Noora Charles Lwanga , Quarshie Prince Romeo , Afari Edwin , Kenu Ernest 
Published: February 2021

Abstract
Introduction: Malaria is endemic in Ghana, accounting for about 40% of all OPD diagnosis. Data on malaria is routinely collected as part of the IDSR monthly reporting forms. Sunyani municipality recorded 56,540 malaria cases in 2016 with about 35% of the cases occurring in children under five years of age. We analyzed malaria surveillance data to identify the distribution of malaria cases by person, place and time and determine the timeliness and completeness of malaria report submission in the municipality.Methods: We analyzed malaria surveillance data in Sunyani municipality reported between 2015 and 2019 from the District Health Management Information System II. We calculated morbidity and mortality rates of cases by person and estimated proportion of cases by sub-districts. We performed trend analysis and calculated disease threshold levels. We presented the findings using tables and figures.Results: Of 639,361 malaria cases suspected, 93.5% (597,512/639,361) were tested, of which 49.4% (295,458/597,512) was positive. Females accounted for 55.7% (164,436/295,458) of the morbidity. Children <5 years recorded the highest proportion, 29.9% (88,135/295,458) of cases in the municipality. The case fatality rate was 3.7% (18/484) and 1.4% (7/484) for persons under age five and over age five, respectively. Abesim (6,276.03 per 10,000) recorded the highest number of cases, and the least cases were in New Dormaa (1,890.97 per 10,000). The majority of malaria cases were in May and October of each year. Antwi-krom recorded the highest rates of completeness and timeliness of 41.9% and 40.0% respectively. Conclusion: More females were diagnosed with malaria and children <5 years recorded the highest proportion of cases in the municipality. Abesim recorded the highest proportion of malaria cases during the period. High patterns of malaria transmissions occurred during months of high rainfalls. None of the sub-districts met the WHO target for timeliness and completeness of report submission. The NMCP should consider interventions such as SMC among children under five, in the Sunyani municipality.
Thermal Waters of Azerbai̇jan – Sources of Renewable Alternati̇ve Energy
Authors: Gadjiev Tair , Babaev nariman , Rustamov Yasin , Karimov Vagif 
Published: February 2021

Abstract
Azerbaijan that is situated in the east of the Caucasian region of the Alpine folding belt is rich in not only oil, gas, and mineral reserves, but in unique mineral water deposits as well. There is over 1000 mineral and thermal water deposits in Azerbaijan. The majority of these deposits have not been exploited yet. These waters can be used for therapeutic purposes as well as an alternative source of renewable energy. This article is dedicated to ways to solve this problem.There are a high production rate (40-50 lit/sec) aquifers with water temperatures close to 100°C at depth of 3000m in Neogene and Paleogene rocks.Geochemical and hydrogeological properties of the mineral and thermal waters of Azerbaijan have separately been analyzed in the article for various regions and specific proposals on their efficient use have been put forward. Thermal waters can be used in heating civil and industrial premises (T=40-600C). Electrical energy can be produced from waters with temperatures above 800C (Jarli, Precaspian-Guba, etc.). The presence of thermal waters distribution patterns in time and space associated with tectonic faults and magmatic processes has been proven from the scientific point of view.
Seroprevalence of Syphilis, HBV and Its Associated Risk Factors Among Pregnant Women Attending at Saint Paul’s Hospital Millennium Medical College, Addis Ababa Ethiopia
Authors: Wabe Yasin awol , Reda Dawit Yihdego , Ali Musa Mohammed 
Published: February 2021

Abstract
Background: Syphilis and Hepatitis B Virus (HBV) share similar modes of transmission. Their occurrence during pregnancy has an adverse effect both on the fetus and pregnant women. The aim of this study was to determine the seroprevalence and associated risk factors of syphilis and HBV among pregnant women. Methods: A cross-sectional study was undertaken from July to September 2019 in 290 pregnant women at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Gestational and socioeconomic data were collected using a questionnaire. Chromatographic kits were used to detect the presence of Hepatitis B surface antigen (HBsAg) and antibody against syphilis infection from the serum of study participants. Data were analyzed by SPSS version 22. Bivariate and multivariable analysis was employed to identify factors associated with seroprevalence of syphilis and HBV. Variables with a p-value of < 0.05 were considered as cut point to determine a significant association. Results: Seroprevalence of HBV and syphilis infection were found to be 4.5% and 2.4 % respectively. Having multiple sexual partner [AOR=3.99, 95%Cl= 1.20-13.38, p=0.025] was significantly associated with HBV infection. Conclusion: In the study the seroprevalence of HBV and syphilis is moderate; having multiple sexual partners was found to be significantly associated with the prevalence of HBV infection.
Upregulated miR-486 Induces Therapeutic Angiogenesis and Improves Infarction Recovery in Rat Myocardial Ischemia Model
Authors: Qi Hong-Wei , Zhang Hai-Tao , Sun Hui-Yan , Zhang Lin , Sun Yang , Wang Li-Sheng , Yuan Biao 
Published: February 2021

Abstract
BackgroundBesides hematopoietic cells, miR-486 is also enriched in cardiac, skeletal, and smooth muscles. However, its roles in regulating the function of cardiomyocytes and tissue repair in myocardial infarction have not been explored yet.MethodsWe investigated the effects of miR-486 on the survival and hypoxic response of cardiomyocytes. Also, using adenovirus-mediated overexpression, we evaluated its therapeutic effects in myocardial repair in a rat acute myocardial infarct (AMI) model.ResultsHypoxia treatment upregulated miR-486 in cardiomyocytes. Moreover, adenovirus-mediated overexpression of miR-486 reduced cell injury, increased cell viability, and decreased apoptosis in hypoxic conditions. In a rat AMI model, administration of Ad-miR-486 reduced infarct size and collagen deposition, increased vessel density, and improved cardiac function. Furthermore, in vivo data suggest that the protective effects of miR-486 in cardiomyocytes were related to its anti-apoptotic function.Conclusion﻿miR-486 overexpression protects myocytes from hypoxia-induced apoptosis and has therapeutic potential in myocardial infarction.
Hydrochemical Characteristics and Water Quality of Groundwater in the Thick Loess Deposits
Authors: Li Shujian , Su He , Li Zhi 
Published: February 2021

Abstract
Water quality and quantity should be paid more attentions for regions with arid climate and thick vadose zones since the limited groundwater cannot be replenished rapidly once polluted. This study focused on the Loess Plateau of China to investigate the geochemical mechanism affecting groundwater chemistry and to calculate contribution rates of multiple sources to groundwater solutes. We employed multiple methods (diagrams, bivariate analyses, hierarchical cluster analysis (HCA), sodium adsorption ratio (SAR), water quality index (WQI), correlation analysis, forward simulation) for the above purposes. We collected 64 groundwater samples in the thick loess deposits in June 2018 (flood season) and April 2019 (dry season). The average concentrations of cation were in the order of Ca2+ > Na+ > Mg2+ > K+ in the flood season, and Na+ > Ca2+ > Mg2+ > K+ in the dry season. The order of anions contents in the flood season and the dry season was HCO3− > SO42− > Cl− > NO3−. The major hydrochemical facies were Ca-HCO3 and Ca·Mg-HCO3 in the flood season, and Na·Ca-HCO3·SO4 and Na-HCO3 in the dry season, respectively. Most of the groundwater (95% in the flood season and 96% in the dry season) was suitable for drinking, and overall water quality (except samples F28 and D13) was acceptable for irrigation. Mineral dissolution and cation exchange were important natural processes affecting groundwater chemistry. A forward model showed that the contribution of atmospheric input, anthropogenic input, evaporite dissolution, silicate weathering and carbonate weathering to solutes in groundwater was 2.3 ± 1.5%, 5.0 ± 7.1%, 19.3 ± 21.4%, 42.8 ± 27.3% and 30.6 ± 27.1% in the flood season, and 9.1 ± 6.4%, 3.4 ± 5.2%, 20.3 ± 15.9, 56.6 ± 23.2%, and 10.7 ± 15.4% in the dry season, respectively. Although the overall contribution of anthropogenic inputs was minor, it was the dominant source of solutes for some groundwater samples. This study provides fundamental information for water management in arid areas.
Isolated Synchronous Multiple Splenic Metastases From Rectal Cancer: a Case Report and Review of the Literature
Authors: Zhao Linxian , Cao Lanqing , Cui Fengwen , Li Wei , Liu Tongjun , Zhang Kai , Li Jiannan 
Published: February 2021

Abstract
Background: Isolated splenic metastasis emanating from colorectal cancer is an extremely rare finding, which usually indicates widely disseminated and multiple metastatic cancer. There have only been 39 cases of isolated splenic metastasis reported in the English literature to date. Case presentation: We report a case of synchronous and isolated multiple splenic metastases derived from rectal cancer. An 84-year-old woman, who presented with and an increased serum carcinoembryonic antigen (CEA) level, was diagnosed with rectal cancer with splenic metastases by abdomen computed tomography (CT). The patient underwent a radical resection of rectal cancer and splenectomy, and the postoperative histopathology conﬁrmed that the splenic lesions were derived from the adenocarcinoma of the rectum. After surgery, the patient recovered well and was recommended for further chemotherapy. Conclusion: Our findings enrich the database of this rare clinical entity and provide experience in the management of splenic metastasis. In addition to revealing a rare case, we also performed a literature review, including a brief discussion about the atypical isolated splenic metastasis from colorectal cancer (CRC).
The Eruption Patterns of The Teeth of Nigerian Local Pigs. Part 1: Profile of Deciduous Teeth
Authors: Okandeji Michael Efeturi , Lijoka Ayodeji David , Atiba Folusho Ayobami , Olopade James Olukayode 
Published: February 2021

Abstract
Background: The pigs, domesticated about 6000 years ago, are highly prolific omnivores belonging to the Family Suidae and Order artiodactyla along with their other hooved counterparts. They qualify as models for various translational research studies (including dental studies) because of their anatomical and physiological similarities to humans. There is however a dearth of information as regards the deciduous dental eruption profile (sequence and timing of eruption) of the Nigerian local pigs (NLP). This study was designed to determine the deciduous eruption profile in the NLP to assist in the management of the breed and in a bid to making the NLP more obvious as suitable animal models in dental research. A total of 51 healthy piglets (from postnatal day 1) were used for this. Their oral cavities were examined every other day for 29 weeks for signs of dental eruption. Looking at Mandibular (Md) and Maxillar (Mx) eruptions for Incisors (I), Canines(C), Premolars (P) and Molars (M), the modular sequence in the NIP was Md/ Mx I3(at birth), C (at birth) →Md I1→Md P3→MxP3 →MxI1 → Md I2 →MdP4 →MxP4 →MxP2→ Md I2 →MxI2 . Result: It was observed that variations in eruption timing exist amongst individuals and sexes while variation in eruption sequence exists between NLP and various breeds of pigs based on the literature.Conclusion: The results of this study will be particularly important to farmers, and researchers into NLP especially those using pigs in Nigeria as a model for translation research.
Surgical Management of Bacille Calmette-Guérin Vaccine-related Regional Lymphadenitis in Infants
Authors: Liu Chen , Huang Minxiang , Geng Lei , Ding Guojian , Liu Xijie , Zheng Bufeng , Feng Wenyu , Fu Tingliang , Xu Xiaoliang 
Published: February 2021

Abstract
BackgroundThe management of Bacille Calmette-Guérin (BCG) vaccine-related regional lymphadenitis in infants is still controversial. We present the results of surgical treatment for this condition.AimTo report our experience in the surgical management in infants with BCG vaccine-related regional lymphadenitis.ResultsFrom January 2013 to June 2020, 65 patients with BCG vaccine-related regional lymphadenitis were retrospectively reviewed. The patients included 55 boys and ten girls. Median age was 3.35 months (5.83±8.17, IQR 3.35-5.1). The infants were all full-term with normal birth weight and received vaccination in the first 24 h of life. All patients underwent surgical excision of the abscess and involved regional lymph nodes, and tolerated anesthesia and the surgical procedure well. Postoperative seroma occurred in 20 patients (20/65). The effusion was aspirated with a fine needle. Sixty-four patients recovered uneventfully. No anti-tuberculosis drugs were given postoperatively. Postoperative abscess recurred in one case and re-operation was required one year later. Postoperative follow-up of three to 12 months showed that all patients had a good outcome.ConclusionSurgical management of infantile BCG vaccine-related lymphadenitis is safe and effective with a low recurrence rate and few complications. Surgical intervention shortened the treatment period and avoided the use of anti-tuberculosis drugs. Surgeons should follow the natural course of this disease and be cautious in choosing surgical treatment.
Building a Weighted Performance Indicator Concept Utilized The Respondent’s Opinion Approach
Authors: Terttiaavini  , Hartono Yusuf , Ermatita Ermatita , Rini Dian Palupi 
Published: February 2021

Abstract
This study discusses building the concept of weighting performance indicators based on respondents' opinions. The opinion of respondents has the power to provide an assessment. So far, the performance appraisal is determined based on the Balanced Scorecard method, AHP, Topics, and others where the dimensions of this method are limited. In companies, performance appraisals are carried out by the HR Department. The specified indicator is sometimes too high, therefore it is considered achieved. The most flexible approach in which the determination of indicators is determined by the respondent who will implement the rule. Weighted performance indicators are constructed by developing an association rule method and ranking method. Performance appraisal structures in the form of multi values ​​and multidimensional can be built using this concept. Items that meet the support value and minimum weight are determined based on the higher frequency. This concept is a new proposal from a mining method developed to produce a performance appraisal model that can be applied to various needs.