bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitis
Authors: Janik Maciej K. , Smyk Wiktor , Kruk Beata , Szczepankiewicz Benedykt , Górnicka Barbara , Lebiedzińska-Arciszewska Magdalena , Potes Yaiza , Simões Inês C. M. , Weber Susanne N. , Lammert Frank , Więckowski Mariusz R. , Milkiewicz Piotr , Krawczyk Marcin 
Published: December 2021

AbstractThe clinical picture of autoimmune hepatitis (AIH) varies markedly between patients, potentially due to genetic modifiers. The aim of this study was to evaluate genetic variants previously associated with fatty liver as potential modulators of the AIH phenotype. The study cohort comprised 313 non-transplanted adults with AIH. In all patients, the MARC1 (rs2642438), HSD17B13 (rs72613567), PNPLA3 (rs738409), TM6SF2 (rs58542926), and MBOAT7 (rs641738) variants were genotyped using TaqMan assays. Mitochondrial damage markers in serum were analyzed in relation to the MARC1 variant. Carriers of the protective MARC1 allele had lower ALT and AST (both P < 0.05). In patients treated for AIH for ≥ 6 months, MARC1 correlated with reduced AST, ALP, GGT (all P ≤ 0.01), and lower APRI (P = 0.02). Patients carrying the protective MARC1 genotype had higher total antioxidant activity (P < 0.01) and catalase levels (P = 0.02) in serum. The PNPLA3 risk variant was associated with higher MELD (P = 0.02) in treated patients, whereas MBOAT7 increased the odds for liver cancer (OR = 3.71). None of the variants modulated the risk of death or transplantation. In conclusion, the MARC1 polymorphism has protective effects in AIH. Genotyping of MARC1, PNPLA3, and MBOAT7 polymorphisms might help to stratify patients with AIH.
Revealing the polar nature of a ferroelectric nematic by means of circular alignment
Authors: Rudquist Per 
Published: December 2021

AbstractThe recent discovery of spontaneously polar nematic liquid crystals—so-called ferroelectric nematics—more than a century after the first discussions about their possible existence—has attracted large interest, both from fundamental scientific and applicational points of view. However, the experimental demonstration of such a phase has, so-far, been non-trivial. Here I present a direct method for the experimental verification of a ferroelectric nematic liquid crystal phase. The method utilizes a single sample cell where the two substrates are linearly and circularly rubbed, respectively, and the ferroelectric nematic phase (NF) is revealed by the orientation of the resulting disclination lines in the cell.
Underdetermined blind source separation of radar signals based on genetic annealing algorithm
Authors: Jin Hongbin , Luo Weilin , Li Hao , Dai Lingyan 
Published: December 2021

AbstractAiming at the problem that the traditional underdetermined blind source separation (UBSS) algorithm does not have high accuracy in estimating the mixing matrix and the number of source signals cannot be determined, a genetic annealing UBSS method with source number estimation function is proposed. This method first performs a short‐time Fourier transform on the observed signal, and then performs single‐source point detection and normalization processing to transform linear clusters into dense clusters. In view of the strong global search ability of the genetic algorithm (GA) and the good local optimization ability of the simulated annealing algorithm, the GA and simulated annealing algorithm are combined, and the number of source signals is determined according to the BWP (Between‐Within Proportion, BWP) index. After estimating the mixing matrix, a modified subspace projection method is used to reconstruct the source signal. The simulation results of four kinds of radar signals show that in the case of dual receiving channels and three receiving channels, compared with the traditional method, the similarity coefficients of the proposed algorithm are greater, which can effectively improve the mixing matrix estimation accuracy, and can accurately determine the number of source signals.
Experience of Radiology Technologists Performing Peripherally Inserted Central Catheters (PICC)
Authors: Aljediea I. , Alshehri M. , Alenazi K. , Memesh A. , Fleet M. 
Published: December 2021

Abstract
Purpose We conducted this study to review our local experience of performing peripherally inserted central catheters by interventional radiology technologists.
Materials and Methods This is a retrospective study of peripherally inserted central catheters performed by interventional radiology technologists. These procedures were performed using ultrasound guidance for venous puncture and fluoroscopy or electrocardiography guidance followed by chest X-ray to confirm tip location.
Results We reviewed all peripherally inserted central catheters performed in interventional radiology between May 2017 and July 2020. The review process included the success rate, number of venous puncture attempts, method of guidance, procedure time, fluoroscopy time, catheter duration to removal, and complications.
Conclusion Interventional radiology technologists can perform peripherally inserted central catheters safely with high success rate. Extending interventional radiology technologists' role to perform peripherally inserted central catheters allow interventional radiologists to do more complex procedures. This enhances the workflow, increases the interventional radiology team efficiency, and improves the waiting time.
Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology: From Synaptic Plasticity to Alzheimer's Disease
Authors: Stevenson Tamara K. , Moore Shannon J. , Murphy Geoffrey G. , Lawrence Daniel A. 
Published: December 2021

AbstractTissue plasminogen activator's (tPA) fibrinolytic function in the vasculature is well-established. This specific role for tPA in the vasculature, however, contrasts with its pleiotropic activities in the central nervous system. Numerous physiological and pathological functions have been attributed to tPA in the central nervous system, including neurite outgrowth and regeneration; synaptic and spine plasticity; neurovascular coupling; neurodegeneration; microglial activation; and blood–brain barrier permeability. In addition, multiple substrates, both plasminogen-dependent and -independent, have been proposed to be responsible for tPA's action(s) in the central nervous system. This review aims to dissect a subset of these different functions and the different molecular mechanisms attributed to tPA in the context of learning and memory. We start from the original research that identified tPA as an immediate-early gene with a putative role in synaptic plasticity to what is currently known about tPA's role in a learning and memory disorder, Alzheimer's disease. We specifically focus on studies demonstrating tPA's involvement in the clearance of amyloid-β and neurovascular coupling. In addition, given that tPA has been shown to regulate blood–brain barrier permeability, which is perturbed in Alzheimer's disease, this review also discusses tPA-mediated vascular dysfunction and possible alternative mechanisms of action for tPA in Alzheimer's disease pathology.
Neglected Scaphocapitate Syndrome
Authors: Kadar Assaf , Iordache Sorin D. 
Published: December 2021

Abstract
Background Scaphocapitate syndrome is a rare injury where the proximal pole of the capitate rotates 90 to 180 degrees. The proximal pole of the capitate, thought to receive its vascular supply retrograde, is rendered avascular in such cases. However, recent evidence of low rates of avascular necrosis in displaced capitate fractures, and new vascular studies of the capitate, challenge this paradigm.
Case Description We report a case of a missed and neglected scaphocapitate syndrome with more than 30 years follow-up. While the patient experienced midcarpal arthritis, the injury had not resulted in capitate proximal pole avascular necrosis as per T1 magnetic resonance imaging studies.
Literature Review Missed and chronic cases of scaphocapitate syndrome were reported previously. Successful outcomes were achieved with anatomical reduction in cases without midcarpal arthritis. Salvage procedures or arthroplasty procedures are recommended with the presence of midcarpal arthritis. However, there are no reports of a neglected case with more than 30 years follow-up with preserved vascularity of the proximal pole of the capitate.
Clinical Relevance This case illustrates that vascularity of the proximal pole of the capitate can be preserved even in longstanding displaced fractures.
Enhanced Drainage Protocol in Large Amoebic Liver Abscess
Authors: Gandhi Jignesh A. , Shinde Pravin H. , Chaudhari Sadashiv N. , Banker Amay M. 
Published: December 2021

Abstract
Background Amebic liver abscess (ALA) contributes significantly to morbidity and mortality in patients of the developing world. Even though medical management is the primary modality of treatment, 15% of the cases are refractory and require intervention for drainage. Pigtail catheterization is inefficient and results in a long duration of hospital stay. So, we conducted a prospective observational study to determine the efficacy and safety of drainage of large ALA using a wide bore 24 French (Fr) drain compared with a conventionally used 10 Fr pigtail catheter.
Materials and Methods A single center prospective observational study was conducted over a period of 5 years and data of 122 patients was collected. After starting empirical medical therapy, patients underwent drainage of ALA with either a 10 French pigtail or a 24 Fr drain. The primary outcome variables were resolution of clinical symptoms such as fever and pain in abdomen, length of hospital stay, and resolution of abscess on imaging at day 3. Secondary outcome was complications related to the procedures.
Results Data of 122 patients was collected. Males constituted a vast majority (96%) of the study population and the fifth decade was the most common age group involved. Alcoholics had a higher chance of developing a large ALA. Sixty-eight patients underwent drainage of the ALA using a 24 Fr drain which resulted in faster resolution of symptoms (2.4 vs. 5.1 days, p-value 0.033), a shorter duration of catheter in situ (6.4 vs. 13.2, p-value 0.011), and a faster drainage of ALA (residual volume at day 3; 177 vs. 212 mL, p-value 0.021). Twenty-eight patients had a biliary communication of which 26 required therapeutic endoscopic retrograde cholangiopancreatography.
Conclusion In patients with a large ALA, placement of a wide bore 24 Fr catheter hastens recovery of the patients when compared with drainage with a standard 10 Fr pigtail catheter. Placement of a biliary stent serves as a useful adjunct for their management and it may obliviate the need for a major biliary diversion surgery.
What’s important for relationship management? The mediating roles of relational trust and satisfaction for loyalty of cooperative banks’ customers
Authors: Damberg Svenja , Schwaiger Manfred , Ringle Christian M. 
Published: December 2021

AbstractBuilding on the corporate reputation model, this study investigates the drivers of customer-based corporate reputation. We consider two corporate reputation dimensions (i.e., the cognitive dimension competence and the affective dimension likeability, and their effects on customer satisfaction and loyalty). Adapting the model to the banking sector, we theoretically extend this model by reasoning that customer satisfaction and relational trust are mediators of the relationship between the two corporate reputation dimensions and loyalty. Studying a sample of 675 customers and members of cooperative banks in Germany, we find perceived attractiveness to be the most important driver of corporate reputation. Furthermore, we confirm a positive relationship between corporate reputation and loyalty, and a mediating effect of both satisfaction and relational trust. With our study, we give support for the proposition of customer satisfaction's as well as relational trust’s role as mediators of the relationship between corporate reputation and loyalty. With this research, we expand our knowledge on the well-known corporate reputation model, which has high relevance and important implications for marketing research and relationship management practice.
Effect of probiotic supplementation on performance, morphology and gene expression associated with immune responses in early age of broiler chickens exposed to stress induced by corticosterone injection
Authors: Abeddargahi Fakhredin , Darmani Kuhi Hassan , Hosseini Moghaddam Seyed Hossein , Roostaei-Ali Mehr Mohammad , Hosseini Anahid , Sajedi Reza H. , Mohammadpour Fatemeh 
Published: December 2021

Context Broiler chickens are exposed to various stressors, which can affect production performance. The use of dietary probiotics is one of the feasible methods to maintain performance, intestinal health, humeral immunity, and ameliorating physiological stress in the broiler. Aims In all, 288 1-day-old male broiler chicks were used to evaluate the effect of probiotic supplementation on performance, morphology, and gene expression associated with immune responses in the starter phase of broiler chickens exposed to stress. Methods In total, 288 1-day-old male broiler chicks (Ross 308) were assigned to evaluate the effects of Bacillus subtilis spore (BSS; Gallipro®200) supplementation at three levels (0, 0.8 × 105 colony-forming units (CFU) and 1.6 × 105 CFU/g feed) with corticosterone (CORT; 4 mg/kg BW at 7–9 days of age) or without CORT (oil) subcutaneous injection. The experiment was conducted in a completely randomised 2 × 3 factorial design. Key results CORT injection and probiotic supplementation led to an increase and decrease respectively, in food conversion ratio compared with the control group (P < 0.05). CORT injections reduced the expression of TLR4, HSP70 and IgA in all parts of the intestine. However, the TLR4 gene expression increased in jejunum by CORT injections. BSS supplementation induced the expression of TLR4 in all sections of the intestine, both in stress and non-stress conditions. In stress-exposed chickens, IgA expression in the jejunum was affected by BSS supplementation. Interaction effects between CORT injections and BSS supplementation on the gene expression were significant in different parts of the intestine. Conclusions Chicks exposed to stress conditions induced by CORT injection showed that the ileum was more susceptible than were the other parts, especially for TLR4 and HSP70 gene expression. BSS-supplemented birds showed more capability to face the stress condition, probably due to intestinal health and immunity-modulated effect of BSS. Implication Formulating a ration with a probiotic can be more effective in stress conditions, through modulating immune-responsive genes in the intestine.
How production networks amplify economic growth
Authors: McNerney James , Savoie Charles , Caravelli Francesco , Carvalho Vasco M. , Farmer J. Doyne 
Published: December 2021

Significance
Technological improvement is the most important cause of long-term economic growth. We study the effects of technology improvement in the setting of a production network, in which each producer buys input goods and converts them to other goods, selling the product to households or other producers. We show how this network amplifies the effects of technological improvements as they propagate along chains of production. Longer production chains for an industry bias it toward faster price reduction, and longer production chains for a country bias it toward faster growth. These predictions are in good agreement with data and improve with the passage of time, demonstrating a key influence of production chains in price change and output growth over the long term.
Self-assembly of photonic crystals by controlling the nucleation and growth of DNA-coated colloids
Authors: Hensley Alexander , Jacobs William M. , Rogers W. Benjamin 
Published: December 2021

SignificanceAssembling optical metamaterials from DNA-coated colloids has been a central goal of programmable self-assembly for decades. Despite significant advances in expanding the structural diversity of colloidal crystals, a lack of understanding of the crystallization pathways has hindered the realization of programmable metamaterials. In this paper, we combine experiments and theory to develop a complete understanding of the crystallization dynamics. We show that the nucleation and growth kinetics of DNA-coated colloids are fundamentally different from those of atoms or small molecules, owing to an effective friction that arises from transient DNA hybridization. By incorporating this effective friction into classical theories, we predict the absolute rates of nucleation and growth with quantitative accuracy, enabling the design of protocols for making photonic crystals.
Oxygen and magnesium mass-independent isotopic fractionation induced by chemical reactions in plasma
Authors: Robert François , Chaussidon Marc , Gonzalez-Cano Adriana , Mostefaoui Smail 
Published: December 2021

Significance
Both the physical effect and the chemical conditions at the origin of the oxygen isotope variations in the solar system have been puzzling questions for 50 y. The data reported here bring the MIF effect (the mass-independent fractionation originally identified on ozone) back to the center of the debate. Similar to Ti isotopes, we observe that the MIF effect for O and Mg is triggered by redox reactions in plasmas. These observations reinforce the idea of a universal mechanism observable in photochemical reactions when molecular collisions involving indistinguishable isotopes yield a symmetrical complex stabilized as a chemical product.
THESEUS1 modulates cell wall stiffness and abscisic acid production in
Arabidopsis thaliana
Authors: Bacete Laura , Schulz Julia , Engelsdorf Timo , Bartosova Zdenka , Vaahtera Lauri , Yan Guqi , Gerhold Joachim Matthias , Tichá Tereza , Øvstebø Camilla , Gigli-Bisceglia Nora , Johannessen-Starheim Svanhild , Margueritat Jeremie , Kollist Hannes , Dehoux Thomas , McAdam Scott A. M. , Hamann Thorsten 
Published: December 2021

Significance
Plants need to constantly adapt to a changing environment. Adaptation includes responses to biotic and abiotic stress. Key elements determining the response to abiotic stress are the cell walls surrounding all plant cells and the phytohormone abscisic acid, which influence turgor pressure in plants. Turgor pressure in plant cells is much higher than in animal cells and a key driver of plant growth and development. Here, we investigate the mechanism regulating cell wall stiffness and coordinating changes in stiffness and turgor with abscisic acid production. We characterize key elements of the mechanism and dissect its mode of action. This knowledge will enable us to improve plant resistance to drought stress, which is necessary due to our changing environment.
Migrant doctors’ narratives about patients
Authors: Lazzaro-Salazar Mariana , Zayts Olga 
Published: December 2021

Abstract
Narratives of personal and vicarious experience are part and parcel of being a doctor, as doctors routinely (re)interpret and (re)tell patients’ narratives when reflecting on clinical cases. Taking an interest in migrant doctors’ self-initiated narratives about patients in doctor-researcher interviews about cultural transitions, this study examines over thirty hours of audio-recordings of forty semi-structured interviews conducted as part of a collaborative project in Chile and Hong Kong. The study explores how migrant doctors construct their professional ‘self’ through narratives about patients, and how these narratives help migrant doctors legitimise their arguments and professional stance in criticizing cultural and societal attitudes towards health and illness, and the professional practices of local doctors. Finally, the paper reflects on the ways in which migrant doctors’ identity positionings provide space for the creation of a “symbolic territory” in which the practices of migrant doctors co-exist within the boundaries of the practices of local doctors in the host culture.
Edge Transport and Self-Assembly of Passive Objects in a Chiral Active Fluid*
Authors: Yang Qing , Liang Huan , Liu Rui , Chen Ke , Ye Fangfu , Yang Mingcheng 
Published: December 2021

Abstract
Topological edge flow and dissipationless odd viscosity are two remarkable features of chiral active fluids composed of active spinners. These features can significantly influence the dynamics of suspended passive particles and the interactions between the particles. By computer simulations, we investigate the transport phenomenon of anisotropic passive objects and the self-assembly behavior of passive spherical particles in the active spinner fluid. It is found that in confined systems, nonspherical passive objects can stably cling to boundary walls and are unidirectionally and robustly transported by edge flow of spinners. Furthermore, in an unconfined system, passive spherical particles are able to form stable clusters that spontaneously and unidirectionally rotate as a whole. In these phenomena, strong particle-wall and interparticle effective attractions play a vital role, which originate from spinner-mediated depletion-like interactions and can be largely enhanced by odd viscosity of spinner fluids. Our results thus provide new insight into the robust transport of cargoes and the nonequilibrium self-assembly of passive intruders.
An experimental analysis of the cooling constant computation
Authors: Perea Martins J E M 
Published: December 2021

Abstract
This work presents the design of an inexpensive electronic system to measure water temperature and generate an experimental data set used to verify the fitting between experimental and theoretical curves of a water-cooling process. The cooling constant is computed with three different theoretical methods to check their efficiency and this approach allows the association of theoretical and experimental aspects of physics, mathematics and electronic instrumentation, which can motivate interesting discussions in the classroom.