bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall Survival Prediction in Renal Cell Carcinoma Patients Using Computed Tomography Radiomic and Clinical Information
Authors: Khodabakhshi Zahra , Amini Mehdi , Mostafaei Shayan , Haddadi Avval Atlas , Nazari Mostafa , Oveisi Mehrdad , Shiri Isaac , Zaidi Habib 
Published: August 2021

AbstractThe aim of this work is to investigate the applicability of radiomic features alone and in combination with clinical information for the prediction of renal cell carcinoma (RCC) patients’ overall survival after partial or radical nephrectomy. Clinical studies of 210 RCC patients from The Cancer Imaging Archive (TCIA) who underwent either partial or radical nephrectomy were included in this study. Regions of interest (ROIs) were manually defined on CT images. A total of 225 radiomic features were extracted and analyzed along with the 59 clinical features. An elastic net penalized Cox regression was used for feature selection. Accelerated failure time (AFT) with the shared frailty model was used to determine the effects of the selected features on the overall survival time. Eleven radiomic and twelve clinical features were selected based on their non-zero coefficients. Tumor grade, tumor malignancy, and pathology t-stage were the most significant predictors of overall survival (OS) among the clinical features (p < 0.002, < 0.02, and < 0.018, respectively). The most significant predictors of OS among the selected radiomic features were flatness, area density, and median (p < 0.02, < 0.02, and < 0.05, respectively). Along with important clinical features, such as tumor heterogeneity and tumor grade, imaging biomarkers such as tumor flatness, area density, and median are significantly correlated with OS of RCC patients.
Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling
Authors: Kurakula Kondababu , Hagdorn Quint A. J. , van der Feen Diederik E. , Vonk Noordegraaf Anton , ten Dijke Peter , de Boer Rudolf A. , Bogaard Harm Jan , Goumans Marie José , Berger Rolf M. F. 
Published: August 2021

AbstractPulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling, endothelial cell dysfunction, increased proliferation of smooth muscle cells and fibroblasts, and inflammation contribute to this abnormal remodelling. Peptidyl-prolyl isomerase Pin1 has been identified as a critical driver of proliferation and inflammation in vascular cells, but its role in the disturbed TGF-β/BMP signalling, endothelial cell dysfunction, and vascular remodelling in PAH is unknown. Here, we report that Pin1 expression is increased in cultured pulmonary microvascular endothelial cells (MVECs) and lung tissue of PAH patients. Pin1 inhibitor, juglone significantly decreased TGF-β signalling, increased BMP signalling, normalized their hyper-proliferative, and inflammatory phenotype. Juglone treatment reversed vascular remodelling through reducing TGF-β signalling in monocrotaline + shunt-PAH rat model. Juglone treatment decreased Fulton index, but did not affect or harm cardiac function and remodelling in rats with RV pressure load induced by pulmonary artery banding. Our study demonstrates that inhibition of Pin1 reversed the PAH phenotype in PAH MVECs in vitro and in PAH rats in vivo, potentially through modulation of TGF-β/BMP signalling pathways. Selective inhibition of Pin1 could be a novel therapeutic option for the treatment of PAH.
Has the introduction of two subspecies generated dispersal barriers among invasive possums in New Zealand?
Authors: Campbell Catriona D. , Cowan Phil , Gruber Bernd , MacDonald Anna J. , Holleley Clare E. , Sarre Stephen D. 
Published: August 2021

AbstractThe introduction of species into new environments provides the opportunity for the evolution of new forms through admixture and novel selection pressures. The common brushtail possum, Trichosurus vulpecula vulpecula from the Australian mainland and T.v.fuliginosus from Tasmania, were introduced multiple times to New Zealand from Australia to become one of New Zealand’s most significant pests. Although derived from two subspecies, possums in New Zealand are generally considered to be a single entity. In a previous analysis, we showed that possums in the Hawkes Bay region of New Zealand appeared to consist of at least two overlapping populations. Here, we extend that analysis using a genotype-by-sequencing approach to examine the origins and population structure of those possums and compare their genetic diversity to animals sampled from Australia. We identify two populations of each subspecies in Hawkes Bay and provide clear evidence of a contact zone between them in which a hybrid form is evident. Our analysis of private alleles shows higher rates of dispersal into the contact zone than away from it, suggesting that the contact zone functions as a sink (and hence as a barrier) between the two subspecies. Given the widespread and overlapping distribution of the two subspecies across both large islands in New Zealand, it is possible that many such contact zones exist. These results suggest an opportunity for a more targeted approach to controlling this pest by recognising sub-specific differences and identifying the contact zones that may form between them.
Capital Round-Tripping: Determinants of Emerging Market Firm Investments into Offshore Financial Centers and Their Ethical Implications
Authors: Karhunen Päivi , Ledyaeva Svetlana , Brouthers Keith D. 
Published: August 2021

AbstractForeign direct investment (FDI) in offshore financial centers (OFCs) is gaining increased attention in business ethics research. Much of this research tends to focus on OFCs as locations where firms can avoid taxes, considering such behavior as unethical. Yet, there is dearth of studies on capital round-tripping by emerging market firms, which is an integral part of this phenomenon. Such round-tripping involves firms sending capital into OFCs only to invest it back in the home country under the guise of “foreign” investment. Presently there is little discussion of the ethical implications of such round-trip FDI activities. In this paper, we conceptualize round-tripping as institutional arbitrage and look at the determinants and ethical implications of such investments into OFCs. Exploring Russian round-tripping we note that firms tend to invest more funds in OFCs that offer a combination of tax and secrecy, or secrecy and property rights protection arbitrage opportunities. In either case firms exploit the opportunities provided by institutional differences between the OFC and Russia while investing back into Russia. Our results tend to indicate that equating OFC investment to tax avoidance and thus deeming it as unethical behavior is too narrow an explanation in the case of emerging economy round-tripping. This is because such investments are often motivated by the unethical behavior of home country stakeholders and may in fact provide benefits to society.
Labour Practice, Decent Work and Human Rights Performance and Reporting: The Impact of Women Managers
Authors: Monteiro Albertina Paula , García-Sánchez Isabel-María , Aibar-Guzmán Beatriz 
Published: August 2021

AbstractThis paper uses a sample of 1243 international firms for the period 2013–2017 to analyse the effect that a greater presence of women in management teams has on business behaviour in relation to labour and human rights, and the mediating role of improved performance in these rights on corporate transparency. The results show that gender diversity in management teams is positively associated with performance in relation to labour and human rights, and that such a performance acts as a mediating factor by fostering a higher disclosure of information regarding these issues. The findings therefore seem to indicate that the presence of women in management teams acts as a driving force for enhanced social responsibility.
K-plex cover pooling for graph neural networks
Authors: Bacciu Davide , Conte Alessio , Grossi Roberto , Landolfi Francesco , Marino Andrea 
Published: August 2021

AbstractGraph pooling methods provide mechanisms for structure reduction that are intended to ease the diffusion of context between nodes further in the graph, and that typically leverage community discovery mechanisms or node and edge pruning heuristics. In this paper, we introduce a novel pooling technique which borrows from classical results in graph theory that is non-parametric and generalizes well to graphs of different nature and connectivity patterns. Our pooling method, namedKPlexPool, builds on the concepts of graph covers andk-plexes, i.e. pseudo-cliques where each node can miss up toklinks. The experimental evaluation on benchmarks on molecular and social graph classification shows thatKPlexPoolachieves state of the art performances against both parametric and non-parametric pooling methods in the literature, despite generating pooled graphs based solely on topological information.
Genuine Savings and Sustainability with Resource Diffusion
Authors: Yamaguchi Rintaro 
Published: August 2021

AbstractWe consider a spatial extension of genuine savings and wealth as a capital-based indicator of sustainability. In both inefficient and efficient economies, where well-being is locally or globally maximized, respectively, the well-known Hotelling rule and Hartwick (Dixit–Hammond–Hoel) investment rules and results are extended, depending on the extent of the spatial diffusion of natural capital. It is shown that the net present value of any future change in neighboring resource stocks affects the current change in intergenerational well-being. Numerical examples show the relevance of such parameters as the diffusion rate, discount rate, and marginal utility of consumption. Moreover, they suggest the exact adjustments to be made in aggregating or disaggregating the sustainability of different spatial units, which is not addressed in the current practice of green or wealth accounting.
Different stress from parasites and mate choice in two female morphs of the blue-tailed damselfly
Authors: Subrero Erica , Pellegrino Irene , Cucco Marco 
Published: August 2021

AbstractIn Odonates, female colour polymorphism is common and implies the presence of two or more female types with different colours and behaviours. To explain this phenomenon, several hypotheses have been proposed that consider morph frequency, population density, the presence of parasites, and mating behaviour. We studied the blue-tailed damselfly Ischnura elegans, a species with a blue androchrome morph and two gynochrome morphs (the common green infuscans, and the rare orange rufescens-obsoleta). The size of adult males and females, the presence of parasites, and pairing behaviour between males and the three female morphs was assessed in field conditions throughout the reproductive season in NW Italy. Moreover, growth and emergence success of larvae produced by the different morphs was analyzed in standardized conditions. In the field, males showed a preference for the gynochrome infuscans females, despite a similar frequency of androchrome females. In test conditions, male preference for the infuscans females was also observed. Paired males and paired androchrome females were larger than unpaired individuals, while there were no differences in size between paired and unpaired infuscans females. Males and androchrome females were more parasitized than infuscans females. The survival and emergence success of larvae produced by androchrome females was higher than those of offspring produced by the infuscans females. Our results suggest that a higher survival of progeny at the larval stage could counterbalance the higher parasitism and the lower pairing success of andromorph adult females and highlight the importance of considering the whole life-cycle in polymorphism studies.
ExoClock project: an open platform for monitoring the ephemerides of Ariel targets with contributions from the public
Authors: Kokori Anastasia , Tsiaras Angelos , Edwards Billy , Rocchetto Marco , Tinetti Giovanna , Wünsche Anaël , Paschalis Nikolaos , Agnihotri Vikrant Kumar , Bachschmidt Matthieu , Bretton Marc , Caines Hamish , Caló Mauro , Casali Roland , Crow Martin , Dawes Simon , Deldem Marc , Deligeorgopoulos Dimitrios , Dymock Roger , Evans Phil , Falco Carmelo , Ferratfiat Stephane , Fowler Martin , Futcher Stephen , Guerra Pere , Hurter Francois , Jones Adrian , Kang Wonseok , Kim Taewoo , Lee Richard , Lopresti Claudio , Marino Antonio , Mallonn Matthias , Mortari Fabio , Morvan Mario , Mugnai Lorenzo V. , Nastasi Alessandro , Perroud Valère , Pereira Cédric , Phillips Mark , Pintr Pavel , Raetz Manfred , Regembal Francois , Savage John , Sedita Danilo , Sioulas Nick , Strikis Iakovos , Thurston Geoffrey , Tomacelli Andrea , Tomatis Alberto 
Published: August 2021

AbstractThe Ariel mission will observe spectroscopically around 1000 exoplanets to further characterise their atmospheres. For the mission to be as efficient as possible, a good knowledge of the planets’ ephemerides is needed before its launch in 2028. While ephemerides for some planets are being refined on a per-case basis, an organised effort to collectively verify or update them when necessary does not exist. In this study, we introduce the ExoClock project, an open, integrated and interactive platform with the purpose of producing a confirmed list of ephemerides for the planets that will be observed by Ariel. The project has been developed in a manner to make the best use of all available resources: observations reported in the literature, observations from space instruments and, mainly, observations from ground-based telescopes, including both professional and amateur observatories. To facilitate inexperienced observers and at the same time achieve homogeneity in the results, we created data collection and validation protocols, educational material and easy to use interfaces, open to everyone. ExoClock was launched in September 2019 and now counts over 140 participants from more than 15 countries around the world. In this release, we report the results of observations obtained until the 15h of April 2020 for 120 Ariel candidate targets. In total, 632 observations were used to either verify or update the ephemerides of 84 planets. Additionally, we developed the Exoplanet Characterisation Catalogue (ECC), a catalogue built in a consistent way to assist the ephemeris refinement process. So far, the collaborative open framework of the ExoClock project has proven to be highly efficient in coordinating scientific efforts involving diverse audiences. Therefore, we believe that it is a paradigm that can be applied in the future for other research purposes, too.
Hiding the unwanted: A University-level campus carry policy
Authors: Ruoppila Sampo 
Published: August 2021

AbstractCampus carry laws have allowed civilians to legally bring their concealed firearms onto college and university campuses in several states in the U.S. over the past decade. Previous studies have addressed the policy’s legal grounds, arguments for and against it, impacts on campus safety, and faculty and students’ attitudes toward it. This paper examines the less addressed topic of policy implementation, especially the role of universities in modifying the outcomes, including what kinds of rules the higher educational institutions themselves have designed and what these approaches mean. The article focuses on Texas, where public higher educational institutions were required to allow campus carry but also given some discretion in implementation. The article provides a qualitative content analysis of policy documents and expert interviews regarding the campus carry policy at The University of Texas at Austin. It argues that the university fully accomplishes the law, but through its policy it has also sought to hide it, removing the issue from everyday life on campus.
Familial Clustering of Trends in Aggression
Authors: van der Laan Camiel M. , van de Weijer Steve G. A. , Nivard Michel G. , Boomsma Dorret I. 
Published: August 2021

Abstract
Objectives
Examine trends in aggressive behavior from 1991 to 2015, investigate whether these trends apply equally to all individuals, and explore the extent to which differences in trends over time cluster within families.

Methods
Our study included 69,465 measures from 40,400 individuals, from 15,437 Dutch families. Aggression was measured between 1 and 4 times by self-report. We fitted a mixed effects model, modeling the effect of time, age, and gender on aggression, and considering the three levels of nesting in the data, i.e. repeated measures, individuals, and families. To investigate if individual differences in trends in aggression over time cluster within families, variance in aggression and in time and age effects was partitioned into within- and between family variance components.

Results
We found a steady decline in aggression over time, between 1991 and 2015, as well as over the life course. Across time and age, women had slightly higher levels of aggression than men. There was clear evidence for clustering within, and variation between families, both in overall aggression levels and in time effects.

Conclusions
We confirm earlier findings of a decline in aggression over the past decades. Not all individuals follow the downward trend over time for aggression to the same extent. Trends over time cluster within families, demonstrating that family factors are not only important to explain variation in aggression levels, but also in understanding differences between individuals in time trends.
Non-aqueous cross hydrolysis: an epoxide-free sol-gel route toward highly porous alumina monoliths
Authors: Carstens Simon , Atanasov Igor , Jähnichen Tim , Oberleiter Bastian , Enke Dirk 
Published: August 2021

AbstractHighly porous alumina monoliths can be fabricated by simultaneous hydrolysis of aluminum alkoxides and salts as homonuclear precursors. The use of carcinogenic epoxides can thus be avoided. In this novel approach, no water is added to the system but hydrolysis is induced by the crystal water of the aluminum salt. Mechanical stabilization and significantly increased porosity values can be achieved when the sol-gel synthesis is performed in an autoclave.
Temperature and entropy–area relation of quantum matter near spherically symmetric outer trapping horizons
Authors: Kurpicz Fiona , Pinamonti Nicola , Verch Rainer 
Published: August 2021

AbstractWe consider spherically symmetric spacetimes with an outer trapping horizon. Such spacetimes are generalizations of spherically symmetric black hole spacetimes where the central mass can vary with time, like in black hole collapse or black hole evaporation. While these spacetimes possess in general no timelike Killing vector field, they admit a Kodama vector field which in some ways provides a replacement. The Kodama vector field allows the definition of a surface gravity of the outer trapping horizon. Spherically symmetric spacelike cross sections of the outer trapping horizon define in- and outgoing lightlike congruences. We investigate a scaling limit of Hadamard 2-point functions of a quantum field on the spacetime onto the ingoing lightlike congruence. The scaling limit 2-point function has a universal form and a thermal spectrum with respect to the time parameter of the Kodama flow, where the inverse temperature$$\beta = 2\pi /\kappa $$β=2π/κis related to the surface gravity$$\kappa $$κof the horizon cross section in the same way as in the Hawking effect for an asymptotically static black hole. Similarly, the tunnelling probability that can be obtained in the scaling limit between in- and outgoing Fourier modes with respect to the time parameter of the Kodama flow shows a thermal distribution with the same inverse temperature, determined by the surface gravity. This can be seen as a local counterpart of the Hawking effect for a dynamical horizon in the scaling limit. Moreover, the scaling limit 2-point function allows it to define a scaling limit theory, a quantum field theory on the ingoing lightlike congruence emanating from a horizon cross section. The scaling limit 2-point function as well as the 2-point functions of coherent states of the scaling limit theory is correlation-free with respect to separation along the horizon cross section; therefore, their relative entropies behave proportional to the cross-sectional area. We thus obtain a proportionality of the relative entropy of coherent states of the scaling limit theory and the area of the horizon cross section with respect to which the scaling limit is defined. Thereby, we establish a local counterpart, and microscopic interpretation in the setting of quantum field theory on curved spacetimes, of the dynamical laws of outer trapping horizons, derived by Hayward and others in generalizing the laws of black hole dynamics originally shown for stationary black holes by Bardeen, Carter and Hawking.
Large-scale historical afforestation failure with Pinus cembra in the Swiss Prealps
Authors: Fragnière Yann , Sonnenwyl Vincent , Clément Benoît , Kozlowski Gregor 
Published: August 2021

AbstractBetween the nineteenth and early twentieth centuries, large-scale afforestation projects were undertaken in the Swiss Prealps. The Swiss stone pine (Pinus cembra L.), an emblematic alpine tree with important economic potential, conservation value and ecological relevance, was one of the species used in these afforestation efforts. We investigated the distribution and site characteristics of all known natural populations and planted stands in the canton of Fribourg (Switzerland). Between 1885 and 1952, artificial afforestation was carried out in the mountainous regions of the canton of Fribourg. Nearly 450,000 seedlings of P. cembra were planted. One century later, only approximately 650 trees survived (0.15% of all planted trees). Moreover, no natural regeneration can be observed in the afforested stands. Since no known harvest activities were undertaken in these planted stands, the whole afforestation campaign of P. cembra in the canton of Fribourg can be described as a failure. Possible causes are investigated and discussed. In this region, P. cembra occurs naturally only in particular microrefugia with markedly rough topography. We argue that the lack of knowledge or consideration of the ecology of the species at a local scale can be an important factor leading to this failure. In the actual context of large-scale afforestation projects anticipating and mitigating the negative effects of global warming, our study highlights the importance of a precise understanding of species ecology and regional conditions.