bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro proton magnetic resonance spectroscopy at 14T for benign and malignant ovary: Part I, signal processing by the nonparametric fast Padé transform
Authors: Belkić Dževad , Belkić Karen 
Published: December 2021

AbstractThe present study deals with two different kinds of time signals, encoded by in vitro proton magnetic resonance spectroscopy (MRS) with a high external static magnetic field, 14.1T (Bruker 600 MHz spectrometer). These time signals originate from the specific biofluid samples taken from two patients, one with benign and the other with malignant ovarian cysts. The latter two diagnoses have been made by histopathologic analyses of the samples. Histopathology is the diagnostic gold standard in medicine. The obtained results from signal processing by the nonparametric derivative fast Padé transform (dFPT) show that a number of resonances assignable to known metabolites are considerably more intense in the malignant than in the benign specimens. Such conclusions from the dFPT include the recognized cancer biomarkers, lactic acid and choline-containing compounds. For example, the peak height ratio for the malignant-to-benign samples is about 18 for lactate, Lac. This applies equally to doublet Lac(d) and quartet Lac(q) resonating near 1.41 and 4.36 ppm (parts per million), respectively. For the choline-containing conglomerate (3.19-3.23 ppm), the dFPT with already low-derivative orders (2nd, 3rd) succeeds in clearly separating the three singlet component resonances, free choline Cho(s), phosphocholine PC(s) and glycerophosphocholine GPC(s). These constituents of total choline, tCho, are of critical diagnostic relevance because the increased levels, particularly of PC(s) and GPC(s), are an indicator of a malignant transformation. It is gratifying that signal processing by the dFPT, as a shape estimator, coheres with the mentioned histopathology findings of the two samples. A very large number of resonances is identifiable and quantifiable by the nonparametric dFPT, including those associated with the diagnostically most important low molecular weight metabolites. This is expediently feasible by the automated sequential visualization and quantification that separate and isolate sharp resonances first and subsequently tackle broad macromolecular lineshape profiles. Such a stepwise workflow is not based on subtracting nor annulling any part of the spectrum, in sharp contrast to controversial customary practice in the MRS literature. Rather, sequential estimation exploits the chief derivative feature, which is a faster peak height increase of the thin than of the wide resonances. This is how the dFPT simultaneously improves resolution (linewidth narrowing) and reduces noise (background flattening). Such a twofold achievement makes the dFPT-based proton MRS a high throughput strategy in tumor diagnostics as hundreds of metabolites can be visualized/quantified to offer the opportunity for a possible expansion of the existing list of a handful of cancer biomarkers.
The Extent of Universal Health Coverage for Maternal Health Services in Eastern Uganda: A Cross Sectional Study
Authors: Lindberg Clara , Nareeba Tryphena , Kajungu Dan , Hirose Atsumi 
Published: December 2021

Abstract
Objective
Monitoring essential health services coverage is important to inform resource allocation for the attainment of the Sustainable Development Goal 3. The objective was to assess service, effective and financial coverages of maternal healthcare services and their equity, using health and demographic surveillance site data in eastern Uganda.

Methods
Between Nov 2018 and Feb 2019, 638 resident women giving birth in 2017 were surveyed. Among them, 386 were randomly sampled in a follow-up survey (Feb 2019) on pregnancy and delivery payments and contents of care. Service coverage (antenatal care visits, skilled birth attendance, institutional delivery and one postnatal visit), effective coverage (antenatal and postnatal care content) and financial coverage (out-of-pocket payments for antenatal and delivery care and health insurance coverage) were measured, stratified by socio-economic status, education level and place of residence.

Results
Coverage of skilled birth attendance and institutional delivery was both high (88%), while coverage of postnatal visit was low (51%). Effective antenatal care was lower than effective postnatal care (38% vs 76%). Financial coverage was low: 91% of women made out-of-pocket payments for delivery services. Equity analysis showed coverage of institutional delivery was higher for wealthier and peri-urban women and these women made higher out-of-pocket payments. In contrast, coverage of a postnatal visit was higher for rural women and poorest women.

Conclusion
Maternal health coverage in eastern Uganda is not universal and particularly low for postnatal visit, effective antenatal care and financial coverage. Analysing healthcare payments and quality by healthcare provider sector is potential future research.
Monitoring and Evaluation of the Lateral Stability of CWR Track
Authors: Atapin Vitaly , Bondarenko Alexey , Sysyn Mykola , Grün Dimitri 
Published: December 2021

AbstractContinuous welded rail (CWR) track has great advantages of low-cost maintenance, environmental influence, and ride comfort. However, the CWR track is subjected to the longitudinal stresses in rails due to temperature influence as well the inhomogeneous stress accumulation due to train loadings. The stresses cause the accelerated track lateral irregularity accumulation that without timely maintenance can cause track buckling. The present paper present a method of the CWR track lateral stability estimation during its lifecycle using the track geometry monitoring information from the track measurement cars. The methods proposes a systematic approach of track stability evaluation based on multiple criteria of track stability evaluation. It takes into account the lateral resistance of the track, actual temperatures, and the lateral geometry condition of the track. The presented case study of a half-year track geometry monitoring and the track stability evaluation in a track curve shows the practical possibility of the recent detection of the track sections with low lateral stability and buckling prevention.
Current practice patterns and gaps in guideline-concordant breast cancer survivorship care
Authors: Brauer Eden R. , Long Elisa F. , Petersen Laura , Ganz Patricia A. 
Published: December 2021

Abstract
Purpose
Breast cancer-specific survivorship care guidelines for the more than 3.8 million survivors in the U.S. are available, but implementation in clinical practice remains challenging. We examined current practice patterns and factors associated with guideline-concordant survivorship care among oncologists.

Methods
A national sample of medical oncologists, recruited using two databases, participated in a survey focused on practice patterns for breast cancer survivorship care. A “survivorship care composite score” was calculated for each respondent based on provision of services recommended in the survivorship guidelines. Descriptive statistics and multivariable linear regression analyses examined associations between physician and practice characteristics and composite scores.

Results
The survey was completed by 217 medical oncologists, with an overall response rate of 17.9% and eligibility rate of 56.9% for those who responded. Oncologists reported high engagement in evaluation of disease recurrence (78%). Performed less frequently were the provision of survivorship care plans (46%), assessment of psychosocial long-term and late effects (34%), and screening for subsequent cancers (34%). Lack of survivorship care training (p = 0.038) and not routinely informing patients about potential late effects (p = 0.003) were significantly associated with poorer survivorship care composite scores.

Conclusions
Despite the availability of disease-specific survivorship care guidelines, adherence to their recommendations in clinical practice is suboptimal. Survey results identified key gaps in survivorship care for breast cancer survivors, particularly related to subsequent primary cancers and psychosocial long-term and late effects.

Implications for Cancer Survivors
Improving the delivery of comprehensive survivorship care for the growing population of breast cancer survivors is a high priority. Disease-specific clinical guidelines for cancer survivorship provide valuable recommendations, but innovative strategies are needed to integrate them into the care of long-term breast cancer survivors.
Experimental investigation on vibration characteristics of the medium–low-speed maglev vehicle–turnout coupled system
Authors: Li Miao , Gao Dinggang , Li Tie , Luo Shihui , Ma Weihua , Chen Xiaohao 
Published: December 2021

AbstractThe steel turnout is one of the key components in the medium–low-speed maglev line system. However, the vehicle under active control is prone to vehicle–turnout coupled vibration, and thus, it is necessary to identify the vibration characteristics of this coupled system through field tests. To this end, dynamic performance tests were conducted on a vehicle–turnout coupled system in a medium–low-speed maglev test line. Firstly, the dynamic response data of the coupled system under various operating conditions were obtained. Then, the natural vibration characteristics of the turnout were analysed using the free attenuation method and the finite element method, indicating a good agreement between the simulation results and the measured results; the acceleration response characteristics of the coupled system were analysed in detail, and the ride quality of the vehicle was assessed by Sperling index. Finally, the frequency distribution characteristics of the coupled system were discussed. All these test results could provide references for model validation and optimized design of medium–low-speed maglev transport systems.
A training plan to implement lung ultrasound for diagnosing pneumonia in children
Authors: Guitart Carmina , Esteban Esther , Becerra Judit , Rodríguez-Fanjul Javier , Cambra Francisco José , Balaguer Mònica , Jordan Iolanda 
Published: December 2021

Abstract
Background
Lung ultrasound (LUS) for critical patients requires trained operators to perform them, though little information exists on the level of training required for independent practice. The aims were to implement a training plan for diagnosing pneumonia using LUS and to analyze the inter-observer agreement between senior radiologists (SRs) and pediatric intensive care physicians (PICPs).

Methods
Prospective longitudinal and interventional study conducted in the Pediatric Intensive Care Unit of a tertiary hospital. Following a theoretical and practical training plan regarding diagnosing pneumonia using LUS, the concordance between SRs and the PICPs on their LUS reports was analyzed.

Results
Nine PICPs were trained and tested on both theoretical and practical LUS knowledge. The mean exam mark was 13.5/15. To evaluate inter-observer agreement, a total of 483 LUS were performed. For interstitial syndrome, the global Kappa coefficient (K) was 0.51 (95% CI 0.43–0.58). Regarding the presence of consolidation, K was 0.67 (95% CI 0.53–0.78), and for the consolidation pattern, K was 0.82 (95% CI 0.79–0.85), showing almost perfect agreement.

Conclusions
Our training plan allowed PICPs to independently perform LUS and might improve pneumonia diagnosis. We found a high inter-observer agreement between PICPs and SRs in detecting the presence and type of consolidation on LUS.

Impact

Lung ultrasound (LUS) has been proposed as an alternative to diagnose pneumonia in children. However, the adoption of LUS in clinical practice has been slow, and it is not yet included in general clinical guidelines.

The results of this study show that the implementation of a LUS training program may improve pneumonia diagnosis in critically ill patients. The training program’s design, implementation, and evaluation are described. The high inter-observer agreement between LUS reports from the physicians trained and expert radiologists encourage the use of LUS not only for pneumonia diagnosis, but also for discerning bacterial and viral patterns.
Determination of tyrosinase-cyanidin-3-O-glucoside and (−/+)-catechin binding modes reveal mechanistic differences in tyrosinase inhibition
Authors: Lee Kyung Eun , Bharadwaj Shiv , Sahoo Amaresh Kumar , Yadava Umesh , Kang Sang Gu 
Published: December 2021

AbstractTyrosinase, exquisitely catalyzes the phenolic compounds into brown or black pigment, inhibition is used as a treatment for dermatological or neurodegenerative disorders. Natural products, such as cyanidin-3-O-glucoside and (−/+)-catechin, are considered safe and non-toxic food additives in tyrosinase inhibition but their ambiguous inhibitory mechanism against tyrosinase is still elusive. Thus, we presented the mechanistic insights into tyrosinase with cyanidin-3-O-glucoside and (−/+)-catechin using computational simulations and in vitro assessment. Initial molecular docking results predicted ideal docked poses (− 9.346 to − 5.795 kcal/mol) for tyrosinase with selected flavonoids. Furthermore, 100 ns molecular dynamics simulations and post-simulation analysis of docked poses established their stability and oxidation of flavonoids as substrate by tyrosinase. Particularly, metal chelation via catechol group linked with the free 3-OH group on the unconjugated dihydropyran heterocycle chain was elucidated to contribute to tyrosinase inhibition by (−/+)-catechin against cyanidin-3-O-glucoside. Also, predicted binding free energy using molecular mechanics/generalized Born surface area for each docked pose was consistent with in vitro enzyme inhibition for both mushroom and murine tyrosinases. Conclusively, (−/+)-catechin was observed for substantial tyrosinase inhibition and advocated for further investigation for drug development against tyrosinase-associated diseases.
Bleeding management in computed tomography-guided liver biopsies by biopsy tract plugging with gelatin sponge slurry
Authors: Handke Nikolaus A. , Koch Dennis C. , Muschler Eugen , Thomas Daniel , Luetkens Julian A. , Attenberger Ulrike I. , Kuetting Daniel , Pieper Claus C. , Wilhelm Kai 
Published: December 2021

AbstractTo evaluate the safety and impact of biopsy tract plugging with gelatin sponge slurry in percutaneous liver biopsy. 300 consecutive patients (158 females, 142 males; median age, 63 years) who underwent computed tomography-guided core biopsy of the liver in coaxial technique (16/18 Gauge) with and without biopsy tract plugging were retrospectively reviewed (January 2013 to May 2018). Complications were rated according to the common criteria for adverse events (NCI-CTCAE). The study cohort was dichotomized into a plugged (71%; n = 214) and an unplugged (29%; n = 86) biopsy tract group. Biopsy tract plugging with gelatin sponge slurry was technically successful in all cases. Major bleeding events were only observed in the unplugged group (0.7%; n = 2), whereas minor bleedings (4.3%) were observed in both groups (plugged, 3.6%, n = 11; unplugged, 0.7%, n = 2). Analysis of biopsies and adverse events showed a significant association between number of needle-passes and overall (P = 0.038; odds ratio: 1.395) as well as minor bleeding events (P = 0.020; odds ratio: 1.501). No complications associated with gelatin sponge slurry were observed. Biopsy tract plugging with gelatin sponge slurry is a technically easy and safe procedure that can prevent major bleeding events following liver biopsy.
Triacontanol modulates salt stress tolerance in cucumber by altering the physiological and biochemical status of plant cells
Authors: Sarwar Mubeen , Anjum Sumreen , Ali Qurban , Alam Muhammad Waqar , Haider Muhammad Saleem , Mehboob Wajid 
Published: December 2021

AbstractCucumber is an important vegetable but highly sensitive to salt stress. The present study was designed to investigate the comparative performance of cucumber genotypes under salt stress (50 mmol L−1) and stress alleviation through an optimized level of triacontanol @ 0.8 mg L−1. Four cucumber genotypes were subjected to foliar application of triacontanol under stress. Different physiological, biochemical, water relations and ionic traits were observed to determine the role of triacontanol in salt stress alleviation. Triacontanol ameliorated the lethal impact of salt stress in all genotypes, but Green long and Marketmore were more responsive than Summer green and 20252 in almost all the attributes that define the genetic potential of genotypes. Triacontanol performs as a good scavenger of ROS by accelerating the activity of antioxidant enzymes (SOD, POD, CAT) and compatible solutes (proline, glycinebetaine, phenolic contents), which lead to improved gas exchange attributes and water relations and in that way enhance the calcium and potassium contents or decline the sodium and chloride contents in cucumber leaves. Furthermore, triacontanol feeding also shows the answer to yield traits of cucumber. It was concluded from the results that the salinity tolerance efficacy of triacontanol is valid in enhancing the productivity of cucumber plants under salt stress. Triacontanol was more pronounced in green long and marketer green than in summer green and 20252. Hence, the findings of this study pave the way towards the usage of triacontanol @ 0.8 mg L−1, and green long and marketer genotypes may be recommended for saline soil.
COVID-19 experiences predicting high anxiety and depression among a sample of BRCA1/BRCA2-positive women in the US
Authors: Dibble Kate E. , Connor Avonne E. 
Published: December 2021

AbstractDuring the COVID-19 pandemic, breast and ovarian cancer survivors experienced more anxiety and depression than before the pandemic. Studies have not investigated the similarities of this trend among BRCA1/2-positive women who are considered high risk for these cancers. The current study examines the impact of COVID-19 experiences on anxiety and depression in a sample of BRCA1/2-positive women in the U.S. 211 BRCA1/2-positive women from medically underserved backgrounds completed an online survey. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression for associations between COVID-19 experiences and self-reported anxiety and depression stratified by demographic factors. Overall, women who reported COVID-19 stigma or discrimination (aOR, 5.14, 95% CI [1.55, 17.0]) experienced significantly more depressive symptoms than women who did not report this experience. Racial/ethnic minority women caring for someone at home during COVID-19 were 3.70 times more likely (95% CI [1.01, 13.5]) to report high anxiety while non-Hispanic white women were less likely (aOR, 0.34, 95% CI [0.09, 1.30], p interaction = 0.011). To date, this is the first study to analyze anxiety and depression considering several COVID-19 predictors among BRCA1/2-positive women. Our findings can be used to inform future research and advise COVID-19-related mental health resources specific to these women.
Silica-supported Fe/Fe–O nanoparticles for the catalytic hydrogenation of nitriles to amines in the presence of aluminium additives
Authors: Chandrashekhar Vishwas G. , Senthamarai Thirusangumurugan , Kadam Ravishankar G. , Malina Ondřej , Kašlík Josef , Zbořil Radek , Gawande Manoj B. , Jagadeesh Rajenahally V. , Beller Matthias 
Published: December 2021

AbstractThe hydrogenation of nitriles to amines represents an important and frequently used industrial process due to the broad applicability of the resulting products in chemistry and life sciences. Despite the existing portfolio of catalysts reported for the hydrogenation of nitriles, the development of iron-based heterogeneous catalysts for this process is still a challenge. Here, we show that the impregnation and pyrolysis of iron(II) acetate on commercial silica produces a reusable Fe/Fe–O@SiO2 catalyst with a well-defined structure comprising the fayalite phase at the Si–Fe interface and α-Fe nanoparticles, covered by an ultrathin amorphous iron(III) oxide layer, growing from the silica matrix. These Fe/Fe–O core–shell nanoparticles, in the presence of catalytic amounts of aluminium additives, promote the hydrogenation of all kinds of nitriles, including structurally challenging and functionally diverse aromatic, heterocyclic, aliphatic and fatty nitriles, to produce primary amines under scalable and industrially viable conditions.
Solvent-controlled regioselective arylation of indoles and mechanistic explorations
Authors: Niu Yuan , Yan Chao-Xian , Yang Xin-Xin , Bai Peng-Bo , Zhou Pan-Pan , Yang Shang-Dong 
Published: December 2021

A new reaction for the regioselective arylation of indoles at C2 or C3 positions achieved by adjusting the solvent and with P(O)tBu2 as an auxiliary group is reported. And the experimental results and DFT confirmed the process.
During Lipreading Training With Sentence Stimuli, Feedback Controls Learning and Generalization to Audiovisual Speech in Noise
Authors: Bernstein Lynne E. , Auer Edward T. , Eberhardt Silvio P. 
Published: December 2021

Purpose:
This study investigated the effects of external feedback on perceptual learning of visual speech during lipreading training with sentence stimuli. The goal was to improve visual-only (VO) speech recognition and increase accuracy of audiovisual (AV) speech recognition in noise. The rationale was that spoken word recognition depends on the accuracy of sublexical (phonemic/phonetic) speech perception; effective feedback during training must support sublexical perceptual learning.

Method:
Normal-hearing (NH) adults were assigned to one of three types of feedback: Sentence feedback was the entire sentence printed after responding to the stimulus. Word feedback was the correct response words and perceptually near but incorrect response words. Consonant feedback was correct response words and consonants in incorrect but perceptually near response words. Six training sessions were given. Pre- and posttraining testing included an untrained control group. Test stimuli were disyllable nonsense words for forced-choice consonant identification, and isolated words and sentences for open-set identification. Words and sentences were VO, AV, and audio-only (AO) with the audio in speech-shaped noise.

Results:
Lipreading accuracy increased during training. Pre- and posttraining tests of consonant identification showed no improvement beyond test–retest increases obtained by untrained controls. Isolated word recognition with a talker not seen during training showed that the control group improved more than the sentence group. Tests of untrained sentences showed that the consonant group significantly improved in all of the stimulus conditions (VO, AO, and AV). Its mean words correct scores increased by 9.2 percentage points for VO, 3.4 percentage points for AO, and 9.8 percentage points for AV stimuli.

Conclusions:
Consonant feedback during training with sentences stimuli significantly increased perceptual learning. The training generalized to untrained VO, AO, and AV sentence stimuli. Lipreading training has potential to significantly improve adults' face-to-face communication in noisy settings in which the talker can be seen.