bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review
Authors: Sneller Marius H. , de Boer Nini , Everaars Sophie , Schuurmans Max , Guloksuz Sinan , Cahn Wiepke , Luykx Jurjen J. 
Published: March 2021

Background:Individuals with severe mental illness experience increased morbidity and mortality compared to the general population. Adverse effects of antipsychotics, including weight gain, may contribute to the development of metabolic syndrome (MetS), which is associated with increased risks of all-cause and cardiovascular disease mortality. We aim to provide a comprehensive overview of clinical, biochemical and genetic factors associated with MetS among patients with schizophrenia spectrum disorders using second-generation antipsychotics (SGA).Methods:A literature search was performed in Pubmed and Embase to identify all cohort studies, cross-sectional studies and clinical trials investigating associations with MetS in patients with schizophrenia spectrum disorders using SGAs. We extracted and enumerated clinical, biochemical and genetic factors reported to be associated with MetS. We defined factors associated with MetS as factors being reported as associated with MetS in two or more studies.Results:58 studies were included in this review (n= 12,123). In total, 62 factors were found to be associated with increased risk of MetS. Thirty one out of 58 studies investigated factors that were reported as associated with MetS in two or more studies. With regard to clinical factors, we found gender, higher age, concomitant use of mood stabilizers, higher baseline and current BMI, earlier SGA exposure, higher dose, longer duration of treatment, psychosis and tobacco smoking to be significantly associated with MetS. Furthermore, the biochemical factors hypo-adiponectinemia, elevated levels of C-reactive protein (CRP) and higher white blood cell (WBC) count were identified as factors associated with MetS. Among pharmacogenetic factors, the rs1414334 C-allele of the HTR2C-gene was associated with MetS in patients using SGA.Conclusion:In this systematic review investigating clinical, biochemical and genetic factors associated with MetS in patients using SGAs we found that higher age, higher baseline BMI, higher current BMI and male as well as female gender were positively associated with MetS across all antipsychotics. This study may set the stage for the application of clinical, biochemical and genetic factors to predict the risk of developing MetS in patients using SGAs. Future research is needed to determine which patients using SGAs are at risk to develop MetS in clinical practice.
LA INCORPORACIÓN DE LAS TIC EN LAS ESTRATEGIAS DIDÁCTICAS: UN ESTUDIO DESDE LAS PRÁCTICAS DOCENTES EN EL NIVEL PRIMARIO
Authors: Lucía Bitti  Echeveste , Bressan Carla María , Monjelat Natalia 
Published: March 2021

Este artículo presenta resultados de una investigación cualitativa, exploratoria y descriptiva, sobre la incorporación de las Tecnologías de la Información y la Comunicación (TIC) en las estrategias didácticas de docentes del nivel primario (segundo ciclo). La misma se realizó en dos escuelas de la ciudad de Rosario (Santa Fe, Argentina) empleando cuestionarios y entrevistas semi-estructuradas. A partir de un análisis estadístico descriptivo, se construyeron categorías de análisis emergentes y se identificaron respuestas textuales significativas. Considerando los discursos de los educadores sobre sus prácticas, los resultados indican que la totalidad de la muestra estaría incluyendo las TIC en sus estrategias didácticas, mostrando una diversidad en cuanto a la caracterización de los docentes, la utilización de diversos recursos y la implementación de éstos en diferentes actividades. Esto permitió identificar componentes y características de las estrategias didácticas tecnológicas en relación a la planificación educativa, las creencias de los docentes sobre estas herramientas, los criterios que establecen a la hora de seleccionar los recursos, la infraestructura tecnológica disponible y la capacitación en el uso de TIC. De esta forma, se aporta al conocimiento sobre el uso de TIC en el nivel primario, con datos concretos que permiten una exploración y descripción de estrategias didácticas en contextos situados.
Bonding of LiNbO3 and Si wafers at room temperature using Si nanolayers
Authors: Watanabe Kaname , Utsumi Jun , Takigawa Ryo 
Published: March 2021

Abstract
We report the room temperature bonding of LiNbO3 and Si wafers based on the use of Si nanolayers. The proposed method employs physical sputtering, which simultaneously activates the surface of an etched Si wafer and forms a Si nanolayer on the surface of a LiNbO3 wafer. Following sputtering, both wafers are immediately brought into contact and the newly formed Si nanolayer acts as a nanoadhesive. The data presented herein demonstrate that this technique is more effective at directly bonding LiNbO3 and Si than the conventional surface-activated bonding method. Following activation, the bonded surface energy, which reflects the bond strength, was estimated to be approximately 2.2 J m−2. This result indicates that the bonding was strong enough to withstand the processes associated with the fabrication of microelectronics devices, including wafer thinning.
Portable particle sorting device based on digital microfluidics utilizing micropillars
Authors: Lee Jae Yong , Kwon Soon Yeol , Kim Seung Deok , Kim Yu Seong , Jung Dong Geon , Kong Seong Ho 
Published: March 2021

Abstract
With introducing the possibility of early diagnosis through biomarker detection, this method has become important in the field of disease diagnosis. Particle sorting based on conventional digital microfluidics (DMF) mostly employs magnetic beads. In this study, the micropillar-based DMF device confirmed the ability of microbead filtering to detect specific biomarkers. The proposed device was implemented using micro-electromechanical systems, and SU-8 micropillar was realized based on the micro-patterning technology. DMF was able to control droplet movements considering the principle of electrowetting on dielectric. The moving speed of a droplet varied according to the electrode shape and applied voltage. As the droplet moved, the polystyrene bead was sorted corresponding to the interval of the fabricated SU-8 micropillar.
A time-shift correction for extraction of viscoelastic parameters from ramp-hold AFM experiments
Authors: Efremov Yuri M. , Kotova Svetlana L. , Khlebnikova Tatiana M. , Timashev Peter S. 
Published: March 2021

Abstract
The stress relaxation and creep measurements are commonly implemented in AFM indentation experiments to analyze the viscoelastic properties of a sample in the time domain. The assumption of an instantaneous step load is often applied which can lead to erroneous estimation of viscoelastic parameters from the experimental data. A viscoelastic solution for the ramp-hold indentation profile might be used but requires higher computational costs. Here, we employed simulations for the ramp-hold indentations for the power-law rheology (PLR) and standard linear solid models. The error coming from the instantaneous load assumption was analyzed and a simple empirical correction for the finite ramp time was employed as a time shift of the hold region. The correction was tested in experiments on cells, in which the data from stress relaxation, creep, and force volume experiments were compared. The correction showed good applicability for the extraction of the PLR viscoelastic parameters.
Metal diffusion model in polymer matrices in vapor phase infiltration
Authors: Sasao Norikatsu , Sugimura Shinobu , Asakawa Koji 
Published: March 2021

Abstract
Metal induction into polymers is an emerging technology that could add inorganic characteristics to organic polymers. The organo-metal precursors dissolve into a polymer matrix from the surface to diffuse throughout the film thickness. In this article, the diffusion of the trimethylaluminum (TMA) in three kinds of polymers; poly(methyl methacrylate) (PMMA), poly(4-vinylpyridine) (P4VP) and poly(N-isopropylacrylamide) (PNIPAM) is discussed. TMA diffusiveness in each polymer was estimated by measuring the depth-profiles of aluminum distribution in the polymer film by X-ray photoelectron spectroscopy. TMA diffusions in each polymer were compared with the coordination energies of TMA to each polymer that were calculated by density functional theory (DFT). The diffusions were shown to be inversely correlated to the absolute value of coordination energy.
High-performance surface acoustic wave devices using composite substrate structures
Authors: Kakio Shoji 
Published: March 2021

Abstract
In this paper, first, the surface acoustic wave (SAW) propagation mode and a method of analyzing the propagation property are introduced briefly. Then, typical composite substrate structures that have been developed to obtain high-performance SAW devices are reviewed. Furthermore, the recent results obtained by the author and research colleagues on the propagation and resonance properties of leaky SAW (LSAW) and longitudinal-type LSAW on dissimilar-material bonded structures comprising a LiTaO3 (LT) or LiNbO3 thin plate with a thickness of less than 1 λ (λː wavelength) and a quartz substrate are described. The control of attenuation and the cause of large coupling factor of LSAWs by utilizing layered structures were also discussed. For the bonded 4 inch wafer of 36°YX-LT/AT90°X-quartz with a thin-plate thickness of 0.3 λ, an admittance ratio of 81 dB, a fractional bandwidth of 4.2%, and resonance and antiresonance factors of approximately 1500 with markedly improved properties compared with a single 36°YX-LT substrate were obtained experimentally at 2.2 GHz.
THE EFFECTS OF GENISTEIN-RICH EDAMAME ON LDL, HS-CRP LEVEL, NEUTROPHIL-LYMPHOCYTE RATIO AND MONOCYTE-LYMPHOCYTE RATIO: STUDY ON RAT MODEL OF ATHEROSCLEROSIS: Experimental Study in Atherosclerosis Induced Male Rats
Authors: Pratama Reza Dian , Maharani Nani , Bahrudin Udin 
Published: March 2021

ABSTRACT
Background: Atherosclerosis is related to hypercholesterolaemia and inflammation. Edamame is one of the soybeans with high levels of genistein which protects the formation of atherosclerosis.
Purpose: This research aimed to evaluate the effects of genistein-rich edamame on LDL, hs-CRP, Neutrophil-Lymphocyte Ratio (NLR) and Monocyte-Lymphocyte Ratio (MLR) on atherosclerosis-induced mice.

Method: This research is a true experimental study with posttest only-controlled group design. Thirty male rats were divided randomly into five groups: negative control group without any intervention, positive control group with atherosclerosis induction, first intervention group with edamame extract supplementation, second intervention group with genistein-rich edamame extract supplementation, and third intervention group treated with atorvastatin. After 28 days, serum LDL, hs-CRP, LDL and MLR were measured.

Results: There were significant differences (p<0.001) of hs-CRP values between the second intervention group compared to the negative control, positive control and first intervention group. Edamame extract lowered LDL cholesterol levels in the second intervention group compared to positive control, but the difference were not statistically significant. There were significant differences (p<0.05) of MLR values between the second intervention group and the negative control and also the first intervention group, and significant differences between the second intervention group and the negative control and also the first intervention group. There was no significant difference on NLR values between all groups.

Conclusion: The administration of genistein rich edamame may reduces the inflammation in the blood vessels better than edamame extract represented by lower hs-CRP and MLR values compared to the edamame extract.

Keywords: Genistein rich-edamame, LDL, hsCRP, neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio
Efek Protektif Methylprednisolone pada Testis Kontralateral Tikus Wistar yang dilakukan Torsio-Detorsio
Authors: Nugroho Leonardo Cahyo , Wibisono Dimas Sindhu , Muhammad Krisna , Fauzi Ardi , Putra Adityas Mahendra , Hidayat Afif Iman 
Published: March 2021

Latar Belakang : Torsio testis merupakan keadaan gawat darurat dan butuh segera dilakukan tindakan bedah. Torsio testis menyumbang 13-54% kasus penyakit skrotum pediatri akut dan terjadi pada 1 dari 4.000 pria berusia <25 tahun serta 1 dari 160 pria di atas 25 tahun. Walaupun sudah dilakukan intervensi di bawah 6 jam namun kematian jaringan testis pasca detorsio masih tinggi, dikarenakan terjadinya cidera iskemik reperfusi akibat produksi ROS (Reactive Oxygen Species) yang berlebihan. Testis kontralateral seringkali ikut terdampak pasca terjadinya torsio-detorsio akibat efek ROS. Pemberian terapi tambahan pasca dilakukan detorsio merupakan kebutuhan yang mendesak untuk ditemukan karena bisa mengurangi kematian jaringan testis akibat cidera iskemik reperfusi.
Metode : Merupakan studi eksperimental dengan rancangan Randomized controlled study with post test only control group design. Sampel penelitian sejumlah 18 tikus wistar dibagi dalam 3 kelompok. Dilakukan torsio pada testis ipsilateral, kemudian dilakukan detorsio dan pemberian terapi intravena. Dilakukan pengamatan index apoptosis (infertilitas) pada variabel Johnsen score, jumlah lapis sel tubulus seminiferus, adhesi neutrofil dan jumlah sel nekrosis dalam Hematoxyline Eosin pada testis kontralateral. Selanjutnya dilakukan analisa statistik, hasil dipresentasikan dalam tabel dan gambar.
Hasil : Terdapat perbedaan yang bermakna antara kelompok Methylprednisolone terhadap kelompok Torsio Detorsio dengan p = 0,008 pada variabel Johnsen score dan jumlah lapis sel tubulus seminiferus.
Diskusi : Methylprednisolone sebagai anti inflamasi terbukti dalam fungsinya mengurangi ROS sehingga bisa mengurangi cidera iskemik reperfusi.
Perbedaan Efektivitas Chair-Based Exercise dan Senam Lansia dalam Meningkatkan Fleksibilitas Lumbal Lanjut Usia
Authors: Rini Maya Puspa , Handoyo Rudy , Suhartono Suhartono 
Published: March 2021

Latar belakang: Fleksibilitas adalah kemampuan sendi bergerak melalui lingkup gerak tanpa nyeri. Senam Lansia (SL) merupakan salah satu usaha untuk mempertahankan dan meningkatkan fleksibilitas lumbal lanjut usia, yang dilakukan dalam posisi berdiri dan memberikan hasil yang baik terhadap fleksibilitas. Beberapa masalah terjadi pada lanjut usia seperti arthritis (khususnya pada sendi lutut) dan penurunan kekuatan otot yang menyebabkan mereka kesulitan untuk beraktivitas dalam posisi berdiri. Chair-Based Exercise (CBE) yang dilakukan dalam posisi duduk, merupakan alternatif latihan yang dapat digunakan untuk meningkatkan fleksibilitas lumbal lanjut usia.
Tujuan: Membuktikan tidak ada perbedaan efektivitas CBE dan SL dalam meningkatkan fleksibilitas lumbal.
Metode: Penelitian ini merupakan penelitian Quasi experimental design. Dua puluh dua lansia dari 3 panti werdha yang berusia 60-74 tahun dibagi menjadi 2 kelompok. Kelompok CBE (n=12) mendapatkan Chair-Based Exercise dan kelompok SL (n=10) mendapatkan senam lansia.
CBE merupakan latihan aerobik yang dilakukan dalam posisi duduk, terdiri dari 3 tahapan: pemanasan, inti dan pendinginan. Sedangkan Senam lansia adalah latihan aerobik yang dilakukan dalam posisi berdiri, terdiri dari 3 tahapan: pemanasan, inti, pendinginan. Kedua latihan berdurasi 30 menit untuk 1 sesi latihan, dilakukan sebanyak 5 kali seminggu selama 6 minggu. Fleksibilitas lumbal dinilai sebelum dan setelah perlakuan dengan menggunakan Modified Back Saver Sit and Reach Test (MBSSRT).
Hasil: Tidak terdapat perbedaan yang bermakna delta nilai MBSSRT tungkai kanan dan kiri antara kelompok CBE dan SL setelah diberikan latihan.
Kesimpulan: Tidak terdapat perbedaan antara CBE dan SL dalam meningkatkan fleksibilitas lumbal lanjut usia.
Kata kunci: Chair-Based Exercise, Senam Lansia, fleksibilitas lumbal, lanjut usia.
A Malignant Melanoma of the Penile : A Very Rare Case Report and Literature Review
Authors: Wijaya Yanuar Hendra , Daniswara Nanda , Santosa Ardy , Soedarso Mohamad Adi , Nugroho Eriawan Agung , Addin Sofyan Rais 
Published: March 2021

Background: Malignant melanoma of the penis is very rare, accounting for approximately 1.4% of all primary penile carcinomas. With a small prevalence of penile melanoma, there is lack of data about quality of the therapy. The primary treatment of melanoma of the penile is surgical, although there is a lack of consensus regarding the extent of treatment that is indicated.
Case Report: A 60-year-old Caucasian man came to Division of Urology, Department of Surgery, Dr. Kariadi General Hospital Semarang with chief complaint painless and fast growing lesions on his penile. His general condition was fine, and has a normal vital signs. On the physical examination of penile region, there were found lesions on the ventral of the glans and penile foreskin and covered with blood and pus, with bilateral inguinal lymph nodes and lung metastasis from Multi Slice Computed Tomography. We already performed partial penectomy and bilateral inguinal lymph nodes dissection with histopathological results a malignant melanoma Clark IV. The final stage of penile melanoma was pT2N1M1. We follow-up the patient until 1 year after procedure, and there wasn’t any recurrence.
Conclusion: Malignant melanoma of the penis is rare. Penile melanoma is highly treatable with surgical excision in its early stages because of resistant to both chemotherapy and radiotherapy. Delay in diagnosed and surgical treatment can lead to an adverse prognosis. The anamnesis, physical examination, and imaging studies must be done appropriately to improve the survival.
ALTERNATIF STRATEGI PENGEMBANGAN OBJEK WISATA KANDI DI KOTA SAWAHLUNTO
Authors: Hamdan Lionard 
Published: March 2021

Otonomi daerah menjadikan pemerintah Kota Sawahlunto giat membangun objek wisata yang berlatar belakang kota bekas tambang batubara. Objek wisata Kandi Kota Sawahlunto merupakan salah satu destinasi wisata yang berada di Provinsi Sumatra Barat. Objek wisata Kandi merupakan objek wisata unggulan di Kota Sawahlunto yang memiliki beberapa objek wisata yang terdiri dari Pacuan kuda kandi, Danau wisata Kandi, Kebun Binatang Kandi, Arena Roadrace permanentKandi, arena Mottocroos dan lain sebagainya. Dalam rangka meningkatkan tingkat kunjungan wisata di Sumatera Barat, khususnya di, Kota Sawahlunto, maka perlu melakukan berbagai langkah-langkah strategis, agar dapat miningkatkan kunjungan wisatawan. Adapun para aktor yang terlibat dalam pengambilan keputusan dalam penelitian ini adalah dinas Pariwisata, Dinas Pekerjaan Umum, Pengelola Obyek Wisata, DPRD Komisi A, dan ASITA. Berdasarkan pengolahan dan analisa data dengan menggunakan Analitical Hirarki Process (AHP), maka didapatkan 3 Strategi pengembangan objek wisata Kandi di Kota sawahlunto, dengan prioritas utamanya adalah 1) Melibatkan dan mengikut sertakan masyarakat; 2) Meningkatkan kegiatanpromosi; dan 3) Meningkatkan infrastruktur objek wisawa Kandi di Kota Sawahlunto.
MANAJEMEN KURIKULUM CAMBRIDGE DI SMPS GOLDEN CHRISTIAN SCHOOL PALANGKA RAYA
Authors: Sinaga Lenna , Berliani Teti , Nugroho Piter Joko 
Published: March 2021

Abstrak: Penelitian bertujuan untuk mendeskripsikan Manajemen Kurikulum Cambridge di SMPS Golden Christian School Palangka Raya. Penelitian ini menggunakan pendekatan kualitatif dengan rancangan studi kasus. Pengumpulan data menggunakan teknik observasi, wawancara, dan studi dokumentasi. Sumber data dalam penelitian ini meliputi: Kepala Sekolah, Wakil Kepala Sekolah Bagian Kurikulum, dan Guru- guru Cambridge dari ketiga Mata Pelajaran (IPA, Matematika, dan Bahasa Inggris). Analisis data menggunakan pola interaktif data, meliputi: reduksi data, penyajian data, dan penarikan kesimpulan. Pengecekan keabsahan data dilakukan dengan menggunakan derajat kepercayaan melalui teknik triangulasi baik sumber maupun metode. Hasil penelitian ini menunjukkan bahwa penerapan kurikulum Cambridge yang dikelola dengan baik memberikan dampak positif dalam meningkatkan mutu pendidikan di SMPS GCS Palangka Raya.
Abstract: The research aims to describe the Cambridge Curriculum Management at the Golden Christian Middle Private School Palangka Raya. This study used a qualitative approach with case study design. Collecting data using observation techniques, interviews, and study documentation. Sources of data in this study include: Principal, Deputy Principal of the Curriculum Section, and Cambridge Teachers for that three Subjects (Science, Mathematics, and English). Data analysis using interactive data model, includes: data reduction, data presentation, and drawing conclusions. Data validity was checked by using a degree of confidence through triangulation techniques, both sources and methods. The results of this study indicate that the application of the Cambridge curriculum which is well managed has a positive impact in improving the quality of education at the GCS Private Middle School Palangka Raya.
PENGARUH KOMPENSASI NON FINANSIAL TERHADAP KINERJA PEGAWAI (ASN) DINAS PROVINSI KALIMANTAN TENGAH
Authors: Winaryo Slamet , Nabila Nur Ainun , Nugroho Piter Joko 
Published: March 2021

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kompensasi non finansial terhadap peningkatan kinerja pegawai (ASN). Sumber data dalam penelitian ini dikumpulkan dengan teknik pengumpulan data melalui angket/kuesioner yang diolah untuk diambil kesimpulan. Berdasarkan analisis regresi diperoleh persamaan regresi Y = 18,293 + 0,641X, yang artinya nilai konstanta harga variabel Y (kinerja pegawai) = 18,293 apabila variabel X (kompensasi non finansial) = 0, dan setiap peningkatan variabel X (kompensasi non finansial) sebanyak 1 % akan meningkatkan nilai variabel Y (kinerja pegawai) sebanyak 0,641 atau 64,1%. Dari hasil uji hipotesis menggunakan uji t diperoleh nilai thitung sebesar 7,967. Kemudian nilai tersebut dikonsultasikan dengan t-tabel pada taraf signifikan 5% diperoleh nilai sebesar 1,657. Karena, thitung > ttabel, dengan nilai sigifikansi 0,00 < 0,05, maka hal ini berarti hipotesis Ho ditolak, sedangkan hipotesis alternatif Ha diterima. Artinya Pemberian kompensasi non finansial berpengaruh secara positif dan siginifikan terhadap kinerja pegawai Aparatur Sipil Negara (ASN) di Dinas Pendidikan Provinsi Kalimantan Tengah.
Abstract: This study aims to determine the effect of non-financial compensation on employee performance improvement (ASN), how much contribution is given and whether it has significance or not. Sources of data in this study were collected using data collection techniques through questionnairess that were processed to draw conclusions. Differentiate regression analysis, the regression equation is Y = 18.293 + 0.641X, which means that the constant value of the variable price Y (employee performance) = 18.293 if the variable X (non-financial compensation) = 0, and each increase in variable X (non-financial compensation) is 1% will increase the value of the variable Y (employee performance) by as much 0.641 or 64,1%. From the results of hypothesis testing using the t test, it was obtained the t value of 7,967. Then the value is consulted with the t-table at the 5% significant level, the value is 1.657. Because t-count > t-table, with a value sigifikansi 0,00 < 0,05, then this means that the hypothesis Ho is rejected, while the alternative hypothesis Ha accepted. This means that the provision of non-financial compensation has a positive and significant effect on the performance of the State Civil Service (ASN) employees at the Education Office of Central Kalimantan Province.