bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a neck collar on brain turgor: a potential role in preventing concussions?
Authors: Dinsmore Michael , Hajat Zakir , Brenna Connor TA , Fisher Joseph , Venkatraghavan Lashmi 
Published: November 2021

BackgroundMild internal jugular vein (IJV) compression, aimed at increasing intracranial fluid volume to prevent motion of the brain relative to the skull, has reduced brain injury markers in athletes suffering repeated traumatic brain injuries. However, an increase in intracranial volume with IJV compression has not been well demonstrated. This study used transorbital ultrasound to identify changes in optic nerve sheath diameter (ONSD) as a direct marker of accompanying changes in intracranial volume.MethodsNineteen young, healthy adult volunteers (13 males and 6 females) underwent IJV compression of 20 cm H2O low in the neck, while in upright posture. IJV cross-sectional area at the level of the cricoid cartilage, and the change in right ONSD 3 mm behind the papillary segment of the optic nerve, were measured by ultrasound. Statistical analysis was performed using a paired t-test with Bonferroni correction.ResultsMean (SD) cross-sectional area for the right IJV before and after IJV compression was 0.10 (0.05) cm2and 0.57 (0.37) cm2, respectively (p=0.001). ONSD before and after IJV compression was 4.6 (0.5) mm and 4.9 (0.5) mm, respectively (p=0.001).ConclusionsThese data verify increased cerebral volume following IJV compression, supporting the potential for reduced brain ‘slosh’ as a mechanism connecting IJV compression to possibly reducing traumatic brain injury following head trauma.
Ambient heat and risks of emergency department visits among adults in the United States: time stratified case crossover study
Authors: Sun Shengzhi , Weinberger Kate R , Nori-Sarma Amruta , Spangler Keith R , Sun Yuantong , Dominici Francesca , Wellenius Gregory A 
Published: November 2021

AbstractObjectiveTo quantify the association between ambient heat and visits to the emergency department (ED) for any cause and for cause specific conditions in the conterminous United States among adults with health insurance.DesignTime stratified case crossover analyses with distributed lag non-linear models.SettingUS nationwide administrative healthcare claims database.ParticipantsAll commercial and Medicare Advantage beneficiaries (74.2 million) aged 18 years and older between May and September 2010 to 2019.Main outcome measuresDaily rates of ED visits for any cause, heat related illness, renal disease, cardiovascular disease, respiratory disease, and mental disorders based on discharge diagnosis codes.Results21 996 670 ED visits were recorded among adults with health insurance living in 2939 US counties. Days of extreme heat—defined as the 95th centile of the local warm season (May through September) temperature distribution (at 34.4°Cv14.9°C national average level)—were associated with a 7.8% (95% confidence interval 7.3% to 8.2%) excess relative risk of ED visits for any cause, 66.3% (60.2% to 72.7%) for heat related illness, 30.4% (23.4% to 37.8%) for renal disease, and 7.9% (5.2% to 10.7%) for mental disorders. Days of extreme heat were associated with an excess absolute risk of ED visits for heat related illness of 24.3 (95% confidence interval 22.9 to 25.7) per 100 000 people at risk per day. Heat was not associated with a higher risk of ED visits for cardiovascular or respiratory diseases. Associations were more pronounced among men and in counties in the north east of the US or with a continental climate.ConclusionsAmong both younger and older adults, days of extreme heat are associated with a higher risk of ED visits for any cause, heat related illness, renal disease, and mental disorders. These results suggest that the adverse health effects of extreme heat are not limited to older adults and carry important implications for the health of adults across the age spectrum.
Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1
Authors: Darwich Abbass , Silvestri Alessandra , Benmebarek Mohamed-Reda , Mouriès Juliette , Cadilha Bruno , Melacarne Alessia , Morelli Lapo , Supino Domenico , Taleb Alexandre , Obeck Hannah , Sustmann Claudio , Losurdo Agnese , Masci Giovanna , Curigliano Giuseppe , Kobold Sebastian , Penna Giuseppe , Rescigno Maria 
Published: November 2021

BackgroundNatural killer (NK) cells require a functional lytic granule machinery to mediate effective antitumor responses. Evading the lytic cargo deployed at the immune synapse (IS) could be a critical step for cancer progression through yet unidentified mechanisms.MethodsNK cell antibody-dependent cellular cytotoxicity (ADCC) is a major determinant of the clinical efficacy of some therapeutic antibodies including the anti-HER2 Trastuzumab. Thus, we screened sera of Trastuzumab-resistant HER2 +patients with breast cancer for molecules that could inhibit NK cell ADCC. We validated our findings in vitro using cytotoxicity assays and confocal imaging of the lytic granule machinery and in vivo using syngeneic and xenograft murine models.ResultsWe found that sera from Trastuzumab-refractory patients could inhibit healthy NK cell ADCC in vitro. These sera contained high levels of the inflammatory protein chitinase 3-like 1 (CHI3L1) compared with sera from responders and healthy controls. We demonstrate that recombinant CHI3L1 inhibits both ADCC and innate NK cell cytotoxicity. Mechanistically, CHI3L1 prevents the correct polarization of the microtubule-organizing center along with the lytic granules to the IS by hindering the receptor of advanced glycation end-products and its downstream JNK signaling. In vivo, CHI3L1 administration drastically impairs the control of NK cell-sensitive tumors, while CHI3L1 blockade synergizes with ADCC to cure mice with HER2 +xenografts.ConclusionOur work highlights a new paradigm of tumor immune escape mediated by CHI3L1 which acts on the cytotoxic machinery and prevents granule polarization. Targeting CHI3L1 could mitigate immune escape and potentiate antibody and cell-based immunotherapies.
Framing the policy debate over tobacco control legislation and tobacco taxation in South Africa
Authors: Zatoński Mateusz Zygmunt , Egbe Catherine O , Robertson Lindsay , Gilmore Anna 
Published: November 2021

BackgroundIn 2018, South Africa opened public consultations on its newly proposed tobacco control bill, resulting in substantial public debate in which a range of arguments, either in favour of or against the Bill, was advanced. These were accompanied by the recurring discussions about the annual adjustments in tobacco taxation. This study uses the concept of framing to examine the public debate in South African print media on the potential effects of the legislation, as well as tobacco tax regulations, between their proponents and detractors.MethodsA systematic search of news articles using multiple data sources identified 132 media articles published between January 2018 and September 2019 that met the inclusion criteria.ResultsSeven overarching frames were identified as characterising the media debate, with the three dominant frames beingEconomic, Harm reduction and vaping,andHealth. The leadingEconomicframe consisted primarily of arguments unsupportive of tobacco control legislation. Economic arguments were promoted by tobacco industry spokespeople, trade unions, organisations of retailers, media celebrities and think tanks—several of which have been identified as front groups or third-party lobbyists for the tobacco industry.ConclusionThe dominance of economic arguments opposing tobacco control legislation risks undermining tobacco control progress. Local and global tobacco control advocates should seek to build relationships with media, as well as collate and disseminate effective counterarguments to those advanced by the industry.
Effective exploitation of a geyser bubble-chamber equipment as a background-free fast neutron detector
Authors: Bertoni R. , Bruno G. , Burgio N. , Corcione M. , Cretara L. , Frullini M. , Fulgione W. , Palmerini G. , Quintino A. , Redaelli N. , Santagata A. , Sorrenti D. G. , Vallicelli E. A. , Zanotti L. 
Published: November 2021

AbstractThe MOSCAB equipment, a geyser-concept bubble-chamber originally thought for the search of dark matter in the form of WIMPs, is employed for the detection of fast neutrons. Once the background-free operating conditions are determined such that the detector is sensitive only to neutrons, which occurs when the neutron energy threshold required for nucleation is higher than approximately 2.5 MeV, the detector response to fast neutrons is investigated using a $${^{241}}$$

241

AmBe neutron source. Sets of detection efficiency functions are then produced via Monte Carlo simulations and post-processing, their validation being performed experimentally and discussed. Finally, the use of the detector to measure the fast neutron activity of very weak n-sources in low neutron background environments, as well as to monitor the cosmic ray variations through the neutron component of the Extensive Air Showers, is considered.
A lattice Boltzmann study of particle settling in a fluctuating multicomponent fluid under confinement
Authors: Xue Xiao , Biferale Luca , Sbragaglia Mauro , Toschi Federico 
Published: November 2021

AbstractWe present mesoscale numerical simulations based on the coupling of the fluctuating lattice Boltzmann method for multicomponent systems with a wetted finite-size particle model. This newly coupled methodologies are used to study the motion of a spherical particle driven by a constant body force in a confined channel with a fixed square cross section. The channel is filled with a mixture of two liquids under the effect of thermal fluctuations. After some validations steps in the absence of fluctuations, we study the fluctuations in the particle’s velocity at changing thermal energy, applied force, particle size, and particle wettability. The importance of fluctuations with respect to the mean settling velocity is quantitatively assessed, especially in comparison with unconfined situations. Results show that the expected effects of confinement are very well captured by the numerical simulations, wherein the confinement strongly enhances the importance of velocity fluctuations, which can be one order of magnitude larger than what expected in unconfined domains. The observed findings underscore the versatility of the proposed methodology in highlighting the effects of confinement on the motion of particles in the presence of thermal fluctuations.
The impact of trans-arterial embolization on the result of chemoradiotherapy in oral cavity cancer
Authors: Nguyen Van Dang , Le Van Quang , Nguyen Thi Thu Nhung , Bui Van Giang , Ta Van To 
Published: November 2021

Objectives: Evaluation of the hemostatic effect of trans-arterial embolization on patients with advanced oral cavity cancer who had bleeding complications while undergoing definitive concurrent chemoradiotherapy (CCRT). Additionally, assess the effect of trans-arterial embolization on treatment response following concurrent chemoradiotherapy, as well as overall survival (OS) and progression-free survival (PFS) in the group of patients following the intervention. Method: From September 2018–June 2021, a retrospective descriptive study was conducted on 16 patients with inoperable, locally advanced oral cavity cancer who received definitive concurrent chemoradiotherapy, experienced acute bleeding complications, and received selective intravascular intervention with various embolization materials at Vietnam National Cancer Hospital. Results: After selective embolization, 16/16 patients ceased bleeding; 1 patient re-bled for the second time after 3 weeks. The average duration of chemoradiotherapy interruption due to intervention was 6.7 days. After CCRT, 15/16 (93.75%) patients achieved a response, with 9/16 (56.25%) patients achieving a complete response. The median OS was 14 months (range, 3–26 months), and the median PFS was 10 months (range, 3–20 months). There were no significant complications, particularly neurological side effects. ConclusionsTumor bleeding is a common and serious complication of CCRT treatment in patients with locally advanced oral cavity cancer. Embolization is a safe and effective method of controlling acute bleeding that has no adverse effect on the outcome of definitive concurrent chemoradiotherapy.
Delta neutrophil index levels can be a good indicator to predict patients with chronic rhinosinusitis who need surgery
Authors: Son Sumin , An Hong Geun , Park Joong Su , Kim Seung Ho , In Seung Min , Kim Jong-Yeup , Lee Suehyun , Cha Jaehun , Lee Jong Wook , Lee Ki-Il 
Published: November 2021

Objectives Predicting the need for surgical treatment among patients with chronic rhinosinusitis (CRS) is challenging. The delta neutrophil index (DNI) has been proposed as a useful laboratory marker of immature granulocytes, which indicates infection or severe inflammation in several diseases. This study evaluated DNI as an early predictor of the need for surgery in patients with CRS. Methods A total of 117 patients diagnosed with CRS were enrolled in this retrospective and observational study. Medical records, including symptoms data, WBC count, ESR level, LUC count, Lund-Mackay scores, and DNI, were reviewed. The receiver operating characteristic (ROC) curves were analyzed to determine the optimal cut-off values for predicting surgery. Results Among 117 patients, 49 patients (41.9%) needed surgical intervention. The areas under the WBC, ESR, LUC, and DNI ROC curves were .571, .600, .592, and .782, respectively. The optimal cut-off value of DNI to predict surgery was .9%. The prognostic precision of DNI showed that the sensitivity was 59.2% and the specificity was 98.5%. In the analysis of risk factors, DNI levels were significantly associated with surgical intervention (odds ratio, 2.22; 95% confidence interval, 1.48-3.34; P < .01). Conclusions The level of DNI, which reflects the severity of the disease, may be a useful predictor for determining the need for surgical intervention in patients with CRS. This is the first literature to verify the role of DNI in upper airway disease.
Clinical diagnostic utility of ultrasound-guided fine needle aspiration biopsy in parotid masses
Authors: Hamour Amr F. , O’Connell Dan , Biron Vincent L. , Allegretto Michael , Seemann Robert , Harris Jeffrey R. , Seikaly Hadi , Côté David W. J. 
Published: November 2021

Background Fine needle aspiration (FNA) is a common diagnostic tool used in the initial evaluation of parotid masses. In the literature, variable diagnostic accuracy of FNA is reported. Therefore, when considering clinical management of these patients, the utility of FNA is unclear. The aim of this study was to determine the capability of ultrasound-guided FNA to differentiate between benign and malignant neoplasms. Further, the way in which FNA results affect clinical decision-making was assessed. Methods Retrospective data were collected for all patients who underwent parotidectomy at a large Canadian tertiary care center between 2011 and 2016. Patient demographics, preoperative imaging reports, preoperative FNA results, and final pathological diagnosis were analyzed. Results Of the 199 patients who underwent parotidectomy, 184 had preoperative ultrasound-guided FNA. There were a total of 13 non-diagnostic FNAs. In diagnosing malignancy, FNA had a sensitivity and specificity of 71.4% and 98.7%, respectively. The positive predictive value (PPV) was 83.3%. The negative predictive value was 97.5%. Of the non-diagnostic FNAs, 2 out of 13 (15.4%) were deemed malignant neoplasms on final pathology. Conclusion FNA is a useful adjunct in the work-up of parotid masses, but it should be used with caution. Due to limited sensitivity, it should not be relied upon as the sole determinant of a surgeon’s management plan.
Correlation Between Average Segment Width and Gamma Passing Rate as a Function of MLC Position Error in Volumetric Modulated Arc Therapy
Authors: Moon Young Min , Bae Sang Il , Han Moo Jae , Jeon Wan , Yu Tosol , Choi Chul Won , Kim Jin Young 
Published: November 2021

Objective: This study analyzed the correlation between the average segment width (ASW) and gamma passing rate according to the multi-leaf collimator (MLC) position error. Method: To evaluate the changes in the gamma passing rate according to the MLC position error, 21 volumetric modulated arc therapy (VMAT) plans were generated using pelvic lymph node metastatic prostate cancer patient's data which is sensitive to MLC position errors as they involve several long, narrow, irregular fields. The ASW for each VMAT plan was calculated using our own code developed using Visual Basic for Applications (VBA). The gamma passing rate of the VMAT plan according to the MLC position error was evaluated using ArcCHECK (Sun Nuclear, Melbourne, FL, USA) while inducing symmetric MLC position errors in 0.25 mm intervals from −1 mm to +1 mm in the infinity medical linear accelerator (Elekta AB, Stockholm, Sweden). Finally, we examined the correlation between the change in the passing rate ([Formula: see text]) due to the MLC position error and the ASW in VMAT through linear regression analysis using the least squares method. Results: The ASW and [Formula: see text] were found to have a linear correlation according to the MLC position error, and the coefficient of determination was 0.88. For a 1 mm position error of MLC in VMAT, the gamma passing rate improved by approximately 11.9% as the ASW increased by 10 mm. Conclusion: These results are expected to be employed as guidelines to minimize the dose uncertainty due to MLC position error in VMAT.
Clinical Hypnosis in Medical Care: A Mixed-Method Feasibility Study
Authors: Lind Sofie Bulling , Jacobsen Henrik Børsting , Solbakken Ole André , Reme Silje Endresen 
Published: November 2021

Background Preoperative hypnosis has shown promising effects in controlling side effects from breast cancer surgery, but the feasibility and effects are largely unknown outside the US. Methods A mixed-methods approach was applied involving a large-scale population survey and a small-scale pilot study. The survey assessed attitudes toward hypnosis in a representative sample from the general population (n = 1049), while the pilot study involved interviews with 5 women who received hypnosis prior to mastectomy/lumpectomy. Results In the survey, 8% reported to have previous experience with hypnosis, and 67% reported willingness to accept hypnosis in a medical setting. Increasing age was associated with more skepticism, while previous experience was associated with less skepticism. In the pilot study, 4 themes were identified: (1) caretaking, (2) experiences related to hypnosis, (3) thoughts and feelings related to diagnosis, and (4) surgery. All participants reported positive experiences related to hypnosis, and none described unpleasant side effects or postoperative pain (pain intensity > 3) after surgery. Conclusions The results indicate that the general public is positive toward clinical hypnosis as a supplement to medical treatment and that preoperative hypnosis is feasible in Norwegian breast cancer patients. Trial Registration ClinicalTrials.gov Identifier: NCT04300283.
A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer
Authors: Garbino Nunzia , Brancato Valentina , Salvatore Marco , Cavaliere Carlo 
Published: November 2021

Background and purpose Perfusion Computed Tomography (CTp) is an imaging technique which allows quantitative and qualitative evaluation of tissue perfusion through dynamic CT acquisitions. Since CTp is still considered a research tool in the field of abdominal imaging, the aim of this work is to provide a systematic summary of the current literature on CTp in the abdominal region to clarify the role of this technique for abdominal cancer applications. Materials and Methods A systematic literature search of PubMed, Web of Science, and Scopus was performed to identify original articles involving the use of CTp for clinical applications in abdominal cancer since 2011. Studies were included if they reported original data on CTp and investigated the clinical applications of CTp in abdominal cancer. Results Fifty-seven studies were finally included in the study. Most of the included articles (33/57) dealt with CTp at the level of the liver, while a low number of studies investigated CTp for oncologic diseases involving UGI tract (8/57), pancreas (8/57), kidneys (3/57), and colon–rectum (5/57). Conclusions Our study revealed that CTp could be a valuable functional imaging tool in the field of abdominal oncology, particularly as a biomarker for monitoring the response to anti-tumoral treatment.
Comparison of long-term efficacy between biological agents following tumor necrosis factor inhibitor failure in patients with rheumatoid arthritis: a prospective cohort study
Authors: Bogas Patricia , Plasencia-Rodriguez Chamaida , Navarro-Compán Victoria , Tornero Carolina , Novella-Navarro Marta , Nuño Laura , Martínez-Feito Ana , Hernández-Breijo Borja , Balsa Alejandro 
Published: November 2021

Background: Currently, there is contradictory evidence regarding the best strategy to follow after discontinuation of a first biological agent in patients with rheumatoid arthritis (RA). We aimed to compare the long-term efficacy of switching to a second tumor necrosis factor inhibitor (TNFi) versus biopharmaceuticals with other mechanisms of action (non-TNFi) in patients with RA who previously failed a first TNFi. Methods: This prospective cohort study analyzed data from 127 patients who discontinued a previous TNFi between 1999 and 2016. Disease activity was assessed at baseline and at 6, 12, and 24 months (m-6, m-12, m-24) after switching. Primary outcome was the proportion of patients achieving good/moderate EULAR response (E-resp). Factors associated with clinical outcomes were assessed using univariate and multivariate logistic regression models. Results: Seventy-seven (61%) patients received a second TNFi and 50 (39%) switched to a non-TNFi. At m-6 and m-12, no differences were observed between groups; nevertheless, at m-24, the proportion of patients with E-resp was higher in the non-TNFi group (49% TNFi group versus 77% non-TNFi group; p = 0.002). In regression models, switching to a non-TNFi was significantly associated with E-resp at m-24 (odds ratio = 3.21; p = 0.01). When assessing the response to the second biological agent based on the reason for discontinuation of the first TNFi, similar results were obtained; at m-24, patients who discontinued the first TNFi due to inefficacy (either primary or secondary) experienced a better E-resp if they had switched to a non-TNFi (primary inefficacy: 52% TNFi group versus 79% non-TNFi group, p = 0.09; secondary inefficacy: 50% versus 76%, p = 0.03). Conclusion: In our cohort of RA patients who discontinued a first TNFi, those who switched to a non-TNFi were three times more likely to attain a sustained clinical response, regardless of whether they had discontinued the first biologic due to a primary or secondary inefficacy.