bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed evolutionary models of massive contact binaries – I. Model grids and synthetic populations for the Magellanic Clouds
Authors: Menon Athira , Langer Norbert , de Mink Selma E , Justham Stephen , Sen Koushik , Szécsi Dorottya , de Koter Alex , Abdul-Masih Michael , Sana Hugues , Mahy Laurent , Marchant Pablo 
Published: August 2021

ABSTRACT
The majority of close massive binary stars with initial periods of a few days experience a contact phase, in which both stars overflow their Roche lobes simultaneously. We perform the first dedicated study of the evolution of massive contact binaries and provide a comprehensive prediction of their observed properties. We compute 2790 detailed binary models for the Large and Small Magellanic Clouds each, assuming mass transfer to be conservative. The initial parameter space for both grids span total masses from 20 to 80$\, \mathrm{M}_\odot$ , orbital periods of 0.6–2 d and mass ratios of 0.6–1.0. We find that models that remain in contact over nuclear time-scales evolve towards equal masses, echoing the mass ratios of their observed counterparts. Ultimately, the fate of our nuclear-time-scale models is to merge on the main sequence. Our predicted period–mass ratio distributions of O-type contact binaries are similar for both galaxies, and we expect 10 such systems together in both Magellanic Clouds. While we can largely reproduce the observed distribution, we overestimate the population of equal-mass contact binaries. This situation is somewhat remedied if we also account for binaries that are nearly in contact. Our theoretical distributions work particularly well for contact binaries with periods &lt;2 d and total masses $\lessapprox 45\, \mathrm{M}_\odot \,$. We expect stellar winds, non-conservative mass transfer, and envelope inflation to have played a role in the formation of the more massive and longer-period contact binaries.
A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules
Authors: Das Bimolendu , Murata Asako , Nakatani Kazuhiko 
Published: August 2021

Abstract
Small-molecules interacting with particular RNAs and modulating their functions are vital tools for RNA-targeting drug discovery. Considering the substantial distribution of the internal loops involving two contiguous cytosines opposite to a single-nucleotide base (Y/CC; Y = C, U or A) within the biologically significant functional RNAs, developing small-molecule probes targeting Y/CC sites should provide profound insight into their functions and roles in biochemical processes. Herein, we report ANP77 as the small-molecule probe for sensing RNA internal loop of Y/CC motifs and molecules binding to the motifs. The Y/CC motifs interact with ANP77 via the formation of a 1:1 complex and quench the fluorescence of ANP77. The flanking sequence-dependent binding to C/CC and U/CC sites was assessed by fluorometric screening, provided the binding heat maps. The quenching phenomena of ANP77 fluorescence was confirmed with intrinsic potential drug target pre-miR-1908. Finally, the binding-dependent fluorescence quenching of ANP77 was utilized in the fluorescence indicator displacement assay to demonstrate the potential of ANP77 as an indicator by using the RNA-binding drugs, risdiplam and branaplam.
Cascade-responsive nanobomb with domino effect for anti-tumor synergistic therapies
Authors: Liu Yang , Wang Yinghui , Song Shuyan , Zhang Hongjie 
Published: August 2021

Abstract
The development of reactive oxygen species (ROS) generation agents that can selectively produce sufficient ROS at the tumor site without external energy stimulation is of great significance for the further clinical application of ROS-based therapies. Herein, we designed a cascade-responsive ROS nanobomb (ZnO2@Ce6/CaP@CPPO/BSA, designated as Z@Ce6/CaP@CB) with domino effect and without external stimulation for the specific generation of multiple powerful ROS storms at the tumor site. The calcium phosphate shell and ZnO2 core gradually degrade and release Ca2+, Zn2+ and hydrogen peroxide (H2O2) under acid stimulation. On the one hand, Zn2+ can enhance the generation of endogenous superoxide anions (·O2–) and H2O2 through the inhibition of the mitochondrial electron transport chain. On the other hand, the generation of large amounts of exogenous H2O2 can cause oxidative damage to tumor cells and further activate bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate (CPPO)-mediated chemiexcited photodynamic therapy. In addition, the oxidative stress caused by the generated ROS can lead to the uncontrolled accumulation of Ca2+ in cells and further result in Ca2+ overload-induced cell death. Therefore, the introduction of Z@Ce6/CaP@CB nanobombs triggered the ‘domino effect’ that caused multiple heavy ROS storms and Ca2+ overload in tumors and effectively activated anti-tumor immune response.
Prevalence of Hepatitis C Virus Infection Identified From Nontargeted Screening Among Adult Visitors in an Academic Appalachian Regional Emergency Department
Authors: Daniel Moore J , Galbraith James , Humphries Roger , Havens Jennifer R 
Published: August 2021

Abstract

Background
We describe the initial results of an adult academic emergency department (ED) nontargeted hepatitis C virus (HCV) screening program serving Appalachia, which is disproportionately affected by the opioid epidemic.

Methods
The study was a retrospective screening study of ED systematic, nontargeted, opt-out HCV testing outcomes from July 2018 through September 2020. Eligibility requirements for “nontargeted” HCV testing included age ≥18 years, verbally able to communicate, receiving bloodwork already as part of routine clinical care, and not opting out of testing. For eligible individuals who did not opt out of testing, an HCV antibody (Ab) test was performed. Reactive Ab tests were confirmed with reflexive HCV RNA testing. The primary study outcome was the characterization of HCV Ab and RNA prevalence.

Results
There were 75 722 unique adult visitors during the period studied. Of these, 54 931 individuals were verbally engaged regarding testing and did not opt out. A total of 34 848 individuals received HCV Ab testing, with 3665 patients (10.5%) having reactive results. RNA confirmatory testing was reflexively performed in all Ab-positive patients, with 1601 (50.3%) positive. The majority of HCV Ab– and RNA-positive patients were young, born after 1965, and were more likely to be White, male, Medicaid insured, and report a history of injection drug use.

Conclusions
ED nontargeted, opt-out testing can identify a high prevalence of HCV infection among adult visitors. HCV infection was disproportionately high among younger, White individuals, likely reflecting the escalating syndemic of opioid injection and HCV transmission in Appalachia.
Lung Abscess and Recurrent Empyema After Infection With Mycoplasma hominis: A Case Report and Review of the Literature
Authors: Moneke Isabelle , Hornuss Daniel , Serr Annerose , Kern Winfried V , Passlick Bernward , Senbaklavaci Oemer 
Published: August 2021

Abstract
Mycoplasma hominis is a rarely identified cause of respiratory infection that can cause significant morbidity and mortality in immunocompromised patients. It is often missed due to the difficult detection of the organism with routine laboratory methods.
We present the case of a 63-year-old male with a history of lymphoma who was transferred to our hospital with recurrent right-sided empyema and lung abscess in the right lower lobe. Advanced microbiological analysis finally revealed infection with M hominis. Despite appropriate antibiotic treatment, prolonged drainage as well as repeated surgery, which eventually resulted in right lower bilobectomy, were necessary for clinical improvement of our patient.
Infection with M hominis may be more prevalent than previously indicated and can cause severe morbidity and mortality in thoracic surgery patients. Due to the diagnostic challenge, the appropriate antimicrobial treatment is often delayed. Inherent resistance to macrolides and inactivity of cell wall-active agents potentially complicate empiric antibiotic therapy. A review of the currently available literature enables a better understanding of the diagnostic difficulties and importance of this infection.
Moral Epistemology and the Revision of Divine Law in Islam
Authors: Siddiqi Ahmed Ali 
Published: August 2021

Abstract
This essay explores the relationship between moral epistemology and legal theory in Islamic thought. Reviewing selected works of Khomeini, Maududi, and Qutb, I show that Islamism, drawing upon certain currents of Muslim intellectual tradition, presupposes a rejection of moral rationalism and on that basis opposes the permanent alteration of explicit divine injunctions. Next, I argue that the unwillingness of ‘Abduh, Iqbal, and Soroush to articulate a consistent moral rationalism prevents these reformists from offering a tenable theoretical alternative to Islamist legalism. I subsequently consider the moral epistemology of classical Mu‘tazili scholar ‘Abd al-Jabbar in order to show how a robust moral rationalism justifies the prudential revision of divine law. On that basis, I suggest that moral rationalism is the necessary epistemic basis of any legal theory that stands as a clear alternative to Islamism while still remaining grounded in the most fundamental tenets of Muslim piety.
Blurrings Of The J-Function
Authors: Aslanyan Vahagn , Kirby Jonathan 
Published: August 2021

Abstract
Inspired by the idea of blurring the exponential function, we define blurred variants of the j-function and its derivatives, where blurring is given by the action of a subgroup of $\mathrm{GL}_2({\mathbb{C}})$. For a dense subgroup (in the complex topology) we prove an Existential Closedness theorem which states that all systems of equations in terms of the corresponding blurred j with derivatives have complex solutions, except where there is a functional transcendence reason why they should not. For the j-function without derivatives we prove a stronger theorem, namely, Existential Closedness for j blurred by the action of a subgroup which is dense in $\mathrm{GL}_2^+(\mathbb{R})$, but not necessarily in $\mathrm{GL}_2({\mathbb{C}})$.
We also show that for a suitably chosen countable algebraically closed subfield $C \subseteq {\mathbb{C}}$, the complex field augmented with a predicate for the blurring of the j-function by $\mathrm{GL}_2(C)$ is model theoretically tame, in particular, ω-stable and quasiminimal.
Time to put it out – nurse-facilitated tobacco treatment in a comprehensive cancer center
Authors: Katz David A , Mott Sarah L , Utech Jane A , Bahlmann Autumn C , Dukes Kimberly A , Seaman Aaron T , Laux Douglas E , Furqan Muhammad , Pollock Zachary J , Vander Weg Mark W 
Published: August 2021

Abstract
Few cancer patients receive guideline-concordant care for treatment of tobacco dependence. The purpose of this pilot trial was to obtain preliminary estimates of effectiveness of an evidence-based practice intervention on the delivery of tobacco treatment and cessation outcomes in cancer patients. We conducted a pragmatic implementation trial with a before-after design in 119 current or recently quit adult smokers with cancer who met with a clinician at a single National Cancer Institute designated comprehensive cancer center (CCC) (n = 61 pre-implementation, n = 58 post-implementation). We used a multi-component strategy based on the Chronic Care Model to implement National Comprehensive Cancer Network (NCCN) guidelines for smoking cessation. Smoking cessation counseling during the index visit was assessed by exit interview and patients were interviewed by phone to assess cessation outcomes at 3-month follow-up. Performance of cessation counseling and 7-day point prevalence abstinence (PPA) were compared across the pre- and post-implementation periods using log-logistic regression, accounting for clustering by nursing staff. More patients had received assistance in quitting at the index visit during the post-implementation period compared to the pre-implementation period (30 vs. 10%, p &lt; .01). At 3-month follow-up, 38 and 14% of participants had discussed smoking cessation medication with a CCC healthcare professional and 57 and 27% of participants had used pharmacotherapy, respectively (p &lt; .01 for both comparisons). Seven-day PPA at 3-month follow-up was similar in both periods, however (14 vs. 12%, respectively). A multi-component tobacco treatment intervention increased the proportion of smokers who received assistance in quitting smoking during usual cancer care but did not improve cessation outcomes.
Multiple approaches to enhancing cancer communication in the next decade: translating research into practice and policy
Authors: Conley Claire C , Otto Amy K , McDonnell Glynnis A , Tercyak Kenneth P 
Published: August 2021

AbstractCommunicating risk and other health information in a clear, understandable, and actionable manner is critical for the prevention and control of cancer, as well as the care of affected individuals and their family members. However, the swift pace of development in communication technologies has dramatically changed the health communication landscape. This digital era presents new opportunities and challenges for cancer communication research and its impact on practice and policy. In this article, we examine the science of health communication focused on cancer and highlight important areas of research for the coming decade. Specifically, we discuss three domains in which cancer communication may occur: (a) among patients and their healthcare providers; (b) within and among families and social networks; and (c) across communities, populations, and the public more broadly. We underscore findings from the prior decade of cancer communication research, provide illustrative examples of future directions for cancer communication science, and conclude with considerations for diverse populations. Health informatics studies will be necessary to fully understand the growing and complex communication settings related to cancer: such works have the potential to change the face of information exchanges about cancer and elevate our collective discourse about this area as newer clinical and public health priorities emerge. Researchers from a wide array of specialties are interested in examining and improving cancer communication. These interdisciplinary perspectives can rapidly advance and help translate findings of cancer communication in the field of behavioral medicine.
Engagement with a digital therapeutic for smoking cessation designed for persons with psychiatric illness fully mediates smoking outcomes in a pilot randomized controlled trial
Authors: Browne Julia , Halverson Tate F , Vilardaga Roger 
Published: August 2021

AbstractUnderstanding the mechanisms of change of digital therapeutics is a critical step to improve digital health outcomes and optimize their development. Access to and engagement with digital content is arguably a core mechanism of change of these interventions. However, the mediational role of app engagement has been largely unexamined. This study evaluated the mediational effect of engaging with a digital therapeutic for smoking cessation designed for adults with psychiatric disorders. The study was a secondary analysis of a pilot clinical trial of 62 adults with serious mental illness who were randomized to receive either a tailored digital therapeutic (Learn to Quit) or a digital therapeutic for the general public (NCI QuitGuide). Engagement was captured using background analytics of app utilization, including (a) number of interactions with app content, (b) minutes/day of app use, and (c) number of days used. The main outcome was reductions in cigarettes per day from baseline to the four-month endpoint. Mediational analysis followed the Preacher and Hayes bootstrap method. Number of application interactions fully mediated reductions in cigarettes per day in the Learn to Quit application but not in QuitGuide (Average Causal Mediation Effect = .31, p = .02). Minutes/day of app use played an uncertain role, and number of days used was not a significant mediator. Results suggest that one of the mechanisms of action of the Learn to Quit device, engagement with theory-based content, functioned as intended. Future research of digital therapeutics should emphasize granular approaches to evaluating apps’ mechanisms of action.
(Re)producing “Whiteness” in Health Care: A Spatial Analysis of the Critical Literature on the Integration of Internationally Educated Health Care Professionals in the Canadian Workforce
Authors: Mickleborough Timothy O. , Martimianakis Maria Athina (Tina) 
Published: August 2021

PurposeThere is a gap in the literature to understand how professionalizing systems intersect with socioeconomic and political realities such as globalization to (re)produce social inequities between those trained locally and those trained abroad. In this critical review, the question of how systemic racism is reproduced in health care is addressed.MethodElectronic databases and nontraditional avenues for searching literature such as reference chaining and discussions with experts were employed to build an archive of texts related to integration of internationally educated health care professionals (IEHPs) into the workforce. Data related to workplace racialization were sought out, particularly those that used antiracist and postcolonial approaches. Rather than an exhaustive summary of the data, a critical review contributes to theory building and a spatial analysis was overlayed on the critical literature of IEHP integration to conceptualize the material effects of the convergence of globalization and professional systems.ResultsThe critical review suggests that professions maintain their value and social status through discourses of “Canadianness” that maintain the homogeneity of professional spaces through social closure mechanisms of credential nonrecognition and resocialization. Power relations are maintained through mechanisms of workplace racialization/spatialization and surveillance which operate through discourses of “foreign-trainedness.”ConclusionsMovement of professionals supports a professional system that on the surface values diversity while maintaining its social status and power through the (re)production of the discourse of “Whiteness.” The analysis shows how in the process domestic graduates are emplaced as the “rightful” citizens of professional paces while IEHPs are marginalized in the workforce.
No One Size Fits All: A Qualitative Study of Clerkship Medical Students’ Perceptions of Ideal Supervisor Responses to Microaggressions
Authors: Bullock Justin L. , O’Brien Meghan T. , Minhas Prabhjot K. , Fernandez Alicia , Lupton Katherine L. , Hauer Karen E. 
Published: August 2021

Purpose
This study explores medical students’ perspectives on the key features of ideal supervisor responses to microaggressions targeting clerkship medical students.

Method
This single-institution, qualitative focus group study, based in an interpretivist paradigm, explored clerkship medical students’ perceptions in the United States, 2020. During semistructured focus groups, participants discussed 4 microaggression scenarios. The authors employed the framework method of thematic analysis to identify considerations and characteristics of ideal supervisor responses and explored differences in ideal response across microaggression types.

Results
Thirty-nine students participated in 7 focus groups, lasting 80 to 92 minutes per group. Overall, students felt that supervisors’ responsibility began before a microaggression occurred, through anticipatory discussions (“pre-brief”) with all students to identify preferences. Students felt that effective bystander responses should acknowledge student preferences, patient context, interpersonal dynamics in the room, and the microaggression itself. Microassaults necessitated an immediate response. After a microaggression, students preferred a brief one-on-one check-in with the supervisor to discuss the most supportive next steps including whether further group discussion would be helpful.

Conclusions
Students described that an ideal supervisor bystander response incorporates both student preferences and the microaggression context, which are best revealed through advanced discussion. The authors created the Bystander Microaggression Intervention Guide as a visual representation of the preferred bystander microaggression response based on students’ discussions. Effective interventions promote educational safety and shift power dynamics to empower the student target.
The Basic Science of Patient–Physician Communication: A Critical Scoping Review
Authors: Forsey Jacquelin , Ng Stella , Rowland Paula , Freeman Risa , Li Connie , Woods Nicole N. 
Published: August 2021

Purpose
Strong verbal communication skills are essential for physicians. Despite a wealth of medical education research exploring communication skills training, learners struggle to become strong communicators. Integrating basic science into the curriculum provides students with conceptual knowledge that improves learning outcomes and facilitates the development of adaptive expertise, but the conceptual knowledge, or “basic science,” of patient–provider communication is currently unknown. This review sought to address that gap and identify conceptual knowledge that would support improved communication skills training for medical trainees.

Method
Combining the search methodology of Arksey and O’Malley with a critical analytical lens, the authors conducted a critical scoping review of literature in linguistics, cognitive psychology, and communications to determine: what is known about verbal communication at the level of word choice in physician–patient interactions? Studies were independently screened by 3 researchers during 2 rounds of review. Data extraction focused on theoretical contributions associated with language use and variation. Analysis linked patterns of language use to broader theoretical constructs across disciplines.

Results
The initial search returned 15,851 unique studies, and 271 studies were included in the review. The dominant conceptual groupings reflected in the results were: (1) clear and explicit language, (2) patient participation and activation, (3) negotiating epistemic knowledge, (4) affiliative language and emotional bonds, (5) role and identity, and (6) managing transactional and relational goals.

Conclusions
This in-depth exploration supports and contextualizes theory-driven research of physician–patient communication. The findings may be used to support future communications research in this field and educational innovations based on a solid theoretical foundation.