bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tylophora hirsuta L. leaf extract attenuates alloxan-induced diabetes in mice by suppressing oxidative stress and α-amylase
Authors: Akhtar Muhammad Furqan , Shagufta Arsalan , Saleem Ammara , Baig Mirza Muhammad Faran Ashraf , Sharif Ali , Rasul Azhar , Abdel-Daim Mohamed M. 
Published: July 2021

Objective:
To evaluate the antidiabetic potential of leaf extracts of Tylophora hirsuta (T. hirsuta).

Methods:
The methanolic and ethyl acetate extracts of T. hirsuta leaves were analyzed by high pressure liquid chromatography. In vitro antioxidant activity was determined by ferric ion reduction, 1, 1-diphenyl-2-picrylhydrazyl, and hydrogen peroxide scavenging methods. In vitro alpha amylase (α-amylase) inhibitory activity of the plant extracts was assessed. In vivo antidiabetic potential was determined in alloxan-induced diabetic mice to assess glycated hemoglobin (HbA1c), oral glucose tolerance, serum amylase, lipid profile, fasting blood glucose, and body weight. Histopathological lesions of the pancreas, liver and kidney were observed. Oxidative stress biomarkers such as superoxide dismutase, catalase and peroxidase were also determined.

Results:
Quercetin, chlorogenic acid, p-coumaric acid, and m-coumaric acid were found in the plant extracts. The methanolic plant extract exhibited higher in vitro antioxidant activities than the ethyl acetate extract. Moreover, methanolic plant extract exhibited (83.90±1.56)% α-amylase inhibitory activity at 3.2 mg/ mL concentration. Animal study showed that the methanolic extract of T. hirsuta improved the levels of fasting blood glucose, HbA1c, serum α-amylase, lipid profile, liver function biomarkers, and kidney functions of diabetic mice. Moreover, the methanolic extract ameliorated diabetes-related oxidative stress by increasing superoxide dismutase and catalase activities and decreasing peroxidase and malondialdehyde levels. Histopathological examination showed that the plant extract had improved the integrity of pancreatic islets of Langerhans and reduced the pathological lesions in the liver and kidney of diabetic mice.

Conclusions:
The methanolic extract of T. hirsuta exhibits pronounced antidiabetic activity in mice through reduction of oxidative stress. The plant extract has several natural antioxidants such as phenolic acids. T. hirsuta extract could serve as a nutraceutical for managing diabetes mellitus.
Improved performance of naringenin herbosomes over naringenin in streptozotocin-induced diabetic rats
Authors: Joshi Ruthvika , Laddha Ankit P. , Kulkarni Yogesh A. , Wairkar Sarika 
Published: July 2021

Objective:
To prepare naringenin herbosome and evaluate its antidiabetic activity.

Methods:
Herbosomes were prepared by the solvent evaporation method. In vitro parameters like particle size, polydispersity index, zeta potential, and entrapment efficiency were estimated and in vitro diffusion study was performed. The in vivo studies were also performed in streptozotocin-induced diabetic male Sprague Dawley rats to evaluate blood glucose, total cholesterol, triglyceride, blood urea nitrogen, total protein, albumin level, aspartate aminotransferase, and alanine aminotransferase levels.

Results:
The optimized herbosome batch showed a particle size of 564.4 nm, a polydispersity index of 0.412, and zeta potential of -39.3 mV. The percentage entrapment of this formulation was 84.04%, with complete drug release within 8 h. Treatment of diabetic rats with naringenin herbosomes for 28 d significantly reduced the elevated level of plasma glucose as compared to plain naringenin. In biochemical parameters, the treatment showed a significant decrease in total cholesterol, triglyceride, and blood urea nitrogen; while elevated levels of aspartate aminotransferase and alanine aminotransferase were returned to normal. Pure naringenin and herbosome formulation at high dose increased the total protein whereas albumin level significantly increased in naringenin herbosomes at the highest dose but not in the pure naringenin treatment group.

Conclusions:
Naringenin herbosomes could improve the metabolic profile of diabetic rats, indicating enhanced antidiabetic activity of herbosome formulation.
Lipid Profile in Infant
Authors: Kumar Ashok , Pandit Kaushik , Chatterjee Purushottam , Mukhopadhyay Pradip , Ghosh Sujoy 
Published: July 2021

Introduction:
Alteration in lipid parameters at birth has a strong association with the development of cardiovascular disease in later life.

Material and Methods:
Sixty-one infants below the age of 6 months underwent evaluation of lipid parameters. The infants studied were categorized into two groups of ≤4 and >4 weeks of age, wherein their lipid parameters were compared.

Results:
The normal distribution of lipid parameters of infants <6 months was generated. The mean total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol was 126.2 ± 26.5, 149.1 ± 48.6, 40.7 ± 14.6, and 69.4 ± 19.4 mg/dl, respectively. The total cholesterol and LDL-cholesterol measured in ≤4 and >4 weeks of age groups were statistically not different (total cholesterol 125.0 ± 30.1 mg/dl vs 127.4 ± 23.4 mg/dl, P = 0.727, and LDL-cholesterol 66.0 ± 19.2 mg/dl vs 75.4 ± 21.2 mg/dl, P = 0.780). However, the HDL-cholesterol and triglycerides measured at ≤4 weeks versus >4 weeks age groups were statistically different (HDL-cholesterol 44.9 ± 17.2 mg/dl vs 36.9 ± 10.8 mg/dl, P = 0.031, and triglyceride 147.4 ± 60.2 mg/dl vs 186.5 ± 75.7 mg/dl, P = 0.030).

Conclusion:
The mean lipid parameters were significantly more atherogenic compared to the Western population. Triglyceride levels and HDL-cholesterol levels change significantly after 4 weeks of age compared to that observed before 4 weeks of age.
A cross-sectional observational study of clinicodermatoscopic features in cutaneous lichen planus in Indian skin
Authors: Tatawati Ashiwini S. , Doshi Bhavana R. , Manjunathswamy Basavapurada Swamy 
Published: July 2021

Background:
Lichen planus (LP) is a papulosquamous skin disorder characterized by violaceous polygonal papules and plaques associated with itching. Dermoscopy in LP shows variable forms of whitish structures that correlate with Wickham striae (WS), vascular structures, and pigmentary changes that aid in its diagnosis.

Aim:
To study the correlation between clinical and dermatoscopic features in cutaneous variants of LP in Indian skin.

Method:
Patients with LP presenting over a period of 1 year were included. Dermoscopy of the lesions in polarized mode was done using video dermatoscope − Dino-Lite Premier AM4113ZT model. Both clinical and dermoscopy findings were photographed, recorded, and studied.

Result:
Fifty-six percent patients (39/70) had classical LP (CLP), 14% patients (10/70) had hypertrophic LP which were the most common clinical variants. Reticulate pattern of WS was the most common pattern observed in 40% (28/70) cases and a new rosette pattern of WS was observed in 13% (9/70) cases. Nonvascular findings such as WS, comedo-like openings, and grey blue dots showed statistically significant association with CLP. Among the pigmentary findings, pepper-like pigmentation was seen in 64% (25/39) CLP and reticulate pattern of pigmentation in 85% (6/7) cases of LP pigmentosus. Perifollicular pigmentation showed statistical significance in 100% cases of lichen planopilaris.

Conclusion:
In view of consistent dermoscopic features observed in LP, it aids as a valuable noninvasive diagnostic tool, many a times obviating the need for skin biopsy.

Limitations:
Small sample size and the exclusion of lesions of LP over the nails, genitals, and oral mucosa.
Producción de papel a partir del banano
Authors: Cabezas William , Freire Carlos , Davila Daniel , Morales Alexander , Hernandez Steven 
Published: July 2021

El papel es uno de los elementos más utilizados en la sociedad moderna, a pesar de que su invención data de épocas remotas. El papel es utilizado para diferentes fines domésticos, laborales e industriales. Su fabricación se realiza a partir de pulpa celosa y fibras vegetales, que han tenido un importante impacto ambiental en los últimos años. En este trabajo se propone el análisis de la elaboración de papel a partir del uso de residuos de la planta de banano, lo que podría ofrecer una mejor utilización de los recursos naturales y un menor impacto a la naturaleza. Además, la fibra natural del banano es resistente y es de fácil obtención en países de Latinoamérica como Ecuador, quien presenta una elevada producción de este. Los resultados encontrados muestran que si es posible la elaboración de papel con fibra de residuos del banano y que es posible la comercialización y buen uso de los recursos.
Palabras Clave: Pseudotallo, papel, banano, economía circular.
Referencias
[1]A. Herrera, «Elaboración Del Papel Orgánico A Base De Pseudotallo De Banano, Cantón Santa Rosa, Provincia De El Oro, Ecuador,» Guayaquil, 2019.
[2]M. Dávalos y S. Zurita, «Implementación de fábrica de papel y derivados empleando residuos de banano como materia prima,» Guayaquil, 2004.
[3]O. Álvarez y E. Howard, «Desarrollo de aplicaciones culinarias para el aprovechamiento del pseudotallo de la planta de plátano (Musa x Paradisiaca),» Guayaquil, 2018.
[4]M. Mazzeo, L. León, F. Mejía, E. Guerrero y D. Botero, «Aprovechamiento industrial de residuos de cosecha y poscosecha del plátano en el departamento de Caldas,» Asociación Colombiana de Facultades de Ingeniería, nº 9, p. 12, 2010.
[5]S. Aguilar y O. Malagon, «Extracción de fibras no leñosas: cabuya (furcraea ANDINA trel.) Y banano (musa PARADISIACA l.) Para estandarizar un proceso tecnológico destinado a la elaboración de pulpa y papel,» Loja, 2016.
[6]A. Cortez, «Elaboración de papel a base de residuos de banano,» Guayaquil, 2014.
[7]V. Guirrajo, «Proyecto de Factibilidad para la creación de una empresa dedicada a la elaboración de papel a base del pinzote de banano, ubicado en el sector Rumicucho, parroquia San Antonio de Pichincha, Cantón Quito. Provincia de Pichincha.,» Quito, 2010.
Pengaruh Publisitas Terhadap Citra Sekolah Tinggi Ilmu Sosial Dan Ilmu Politik Pahlawan 12
Authors: Pratama David 
Published: July 2021

Penelian ini membahas pengaruh publisitas terhadap citra Sekolah Tinggi Ilmu Sosial dan Ilmu Polik Pahlawan 12 Sungailiat Bangka di kalangan masyarakat Kecamatan Sungailiat Kabupaten Bangka. Teori yang digunakan adalah teori prinsip?prinsip publisitas dan elemen?elemen citra. Jenis penelian adalah korelasional dengan pendekatan kuantaf. Populasi masyarakat Kecamatan Sungailiat dengan sampel penelian sebanyak 398 orang. Teknik pengumpulan data menggunakan kuesioner, wawancara, dan studi kepustakaan. Hasil pembahasan nilai Sig. 0,000 lebih kecil dari 0,05 sehingga Ho ditolak dan H1 diterima, yang arnya publisitas berpengaruh posif dan signi?kan terhadap citra STISIPOL Pahlawan 12 di kalangan masyarakat Kecamatan Sungailiat Kabupaten Bangka. Meskipun begitu, dengan besar koe?sien determinasi adalah 0,040 atau 4% terlihat keeratan hubungan antara variabel rendah; arnya bahwa publisitas dak begitu berpengaruh besar terhadap citra STISIPOL Pahlawan 12 Sungailiat Bangka, sedangkan 96% dipengaruhi oleh variabel lain.
Evaluación de parámetros de segmentación en OBIA para la clasificación de coberturas del suelo a partir de imágenes VANT
Authors: Hinojosa-Espinoza Susana I. , Gallardo-Salazar José L. , Hinojosa-Espinoza Félix J. C. , Meléndez-Soto Anulfo 
Published: July 2021

<p>Unmanned Aerial Vehicles (UAVs) have given a new boost to remote sensing and image classification techniques due to the high level of detail among other factors. Object-based image analysis (OBIA) could improve classification accuracy unlike to pixel-based, especially in high-resolution images. OBIA application for image classification consists of three stages i.e., segmentation, class definition and training polygons, and classification. However, defining the parameters: spatial radius (SR), range radius (RR) and minimum region size (MR) is necessary during the segmentation stage. Despite their relevance, they are usually visually adjusted, which leads to a subjective interpretation. Therefore, it is of utmost importance to generate knowledge focused on evaluating combinations of these parameters. This study describes the use of the mean-shift segmentation algorithm followed by <em>Random Forest </em>classifier using Orfeo Toolbox software. It was considered a multispectral orthomosaic derived from UAV to generate a suburban map land cover in town of El Pueblito, Durango, Mexico. The main aim was to evaluate efficiency and segmentation quality of nine parameter combinations previously reported in scientific studies.This in terms of number generated polygons, processing time, discrepancy measures for segmentation and classification accuracy metrics. Results evidenced the importance of calibrating the input parameters in the segmentation algorithms. Best combination was RE=5, RR=7 and TMR=250, with a Kappa index of 0.90 and shortest processing time. On the other hand, RR showed a strong and inversely proportional degree of association regarding the classification accuracy metrics.</p>
Analisis kelembagaan unit pengolahan PKMB Kota Ambon
Authors: Siahaya Rosni Astuti , Joris Megie 
Published: July 2021

Kota Ambon memiliki ketersedian potensi sumberdaya kelautan dan perikanan yang dapat dikembangkan. Untuk mengembangkan potensi sumberdaya tersebut maka perlu peningkatan kualitas sumberdaya manusia. Permasalahan yang dihadapi unit usaha pengolahan hasil perikanan PKBM Makmur Jaya adalah keterbatasan modal kerja, manajemen usaha yang masih sederhana, serta keterbatasan akses pasar. Kondisi ini tentunya berdampak terhadap aktivitas produksi yang dilakukan oleh unit usaha pengolahan hasil perikanan PKBM Makmur Jaya. Penelitian ini bertujuan untuk menganalisis faktor-faktor apa saja yang dapat menentukan keberhasilan dan untuk mengukur tingkat perkembangan pada unit pengolahan hasil perikanan PKBM Makmur Jaya Kota Ambon Metode Penelitian yang digunakan adalah survey dan wawancara terstruktur kepada semua pihak yang terlibat dalam lingkup Unit PKMB Makmur Jaya Ambon dengan menggunakan instrumen berupa kuesioner atau lembaran pertanyaan. Hasil penelitian yang diperoleh meliputi : pengembangan visi, manajemen organisasi, sumberdaya manusia, sumberdaya keuangan, sumberdaya eksternal dengan fokus pada kemitraan, sarana dan prasarana, serta isu-isu pengelolaan sumberdaya perikanan. karakteristik sumberdaya dan komponen kunci (27,27%) berada pada kwadran dimana mendesak untuk ditingkatkan, (69,76%) berada pada kwadran kinerja lembaga tetap dipertahankan dan (2,32%) berada pada kwadran tidak terlalu mendesak untuk disempurnakan bisa ditangani kemudian. Tingkat perkembangan sumberdaya kelembagaan unit pengolahan hasil perikanan PKBM Makmur Jaya untuk semua Komponen Sumberdaya Institusi berada pada kemajuan yang variatif 4,54% berada pada tahapan permulaan, 22,72 % berada pada tahapan perkembangan, 51,16% berada pada tahap konsolidasi dan 20,45% pada tahapan keberlanjutan.
TÁC DỤNG CỦA CỦA TẬP YOGA LÊN HUYẾT ÁP VÀ MỘT SỐ CHỈ SỐ NHÂN TRẮC Ở BỆNH NHÂN TĂNG HUYẾT ÁP NGUYÊN PHÁT ĐỘ 1
Authors: Văn Tuấn Nguyễn , Thị Ái Khuê Hoàng 
Published: July 2021

Điều trị THA bên cạnh dùng các loại thuốc hạ huyết áp thì vấn đề thay đổi lối sống cũng góp phần quan trọng trong việc kiểm soát trị số huyết áp của bệnh nhân. Yoga giúp giảm huyết áp thông qua giảm căng thẳng, giảm cholesterol máu và tăng độ đàn hồi của thành mạch. Để góp phần cung cấp cơ sở khoa học cho người bị cao huyết áp kiểm soát thông qua tập luyện Yoga, chúng tôi tiến hành đề tài này. Mục tiêu: (1) Đánh giá tác dụng của tập Yoga trong việc kiểm soát huyết áp ở bệnh nhân tăng huyết áp độ 1 và (2) Đánh giá tác dụng của tập Yoga lên một số chỉ số nhân trắc ở bệnh nhân tăng huyết áp độ I. Đối tượng nghiên cứu: Bệnh nhân THA nguyên phát độ 1 theo tiêu chuẩn chẩn đoán của WHO/ISH 2004, tuổi từ 30 đến 60 tuổi, hiện tại không dùng thuốc điều trị THA và các thuốc ảnh hưởng đến các chỉ số nghiên cứu. Thiết kế nghiên cứu: Nghiên cứu can thiệp có đối chứng. Kết quả: Tập Yoga làm giảm có ý nghĩa thống kê các chỉ số huyết áp tâm thu và huyết áp tâm trương ở bệnh nhân tăng huyết áp độ 1 so với không tập Yoga. Tập Yoga cũng làm giảm có ý nghĩa thống kê chỉ số BMI, vòng bụng và bề dày lớp mỡ dưới da ở bệnh nhân tăng huyết áp độ 1 so với không tập Yoga.
TÌNH TRẠNG SUY DINH DƯỠNG CỦA BỆNH NHÂN SUY THẬN MẠN TÍNH CÓ LỌC MÁU CHU KỲ TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN
Authors: Thị Hà Ngô , Thị Thùy Dương Trương , Tuấn Tú Trần 
Published: July 2021

Đặt vấn đề: Bệnh nhân suy thận mạn và đặc biệt là nhóm bệnh nhân có lọc máu chu kỳ, liên quan chặt chẽ tới tình trạng suy dinh dưỡng của bệnh nhân do cơ thể giảm protein và giảm năng lượng dự trữ. Mục tiêu: Đánh giá tình trạng suy dinh dưỡng của bệnh nhân suy thận mạn tính có lọc máu chu kì tại bệnh viện Trung Ương Thái nguyên năm 2020.Đối tượng và phương pháp nghiên cứu: Nghiên cứu được tiến hành theo phương pháp mô tả, thiết kế cắt ngang trên toàn bộ bệnh nhân suy thận mạn tính có lọc máu chu kỳ tại khoa Nội Thận tiết niệu và lọc máu bệnh viện Trung Ương Thái Nguyên. Kết quả nghiên cứu: Tỷ lệ bệnh nhân bị thiếu năng lượng trường diễn (BMI < 18,5) chiếm tỷ lệ khá cao (27,8%). Thời gian điều trị của người bệnh càng dài thì tỷ lệ thiếu năng lượng trường diễn càng cao (đánh giá bằng chỉ số BMI) với p < 0,05. Đánh giá tình trạng dinh dưỡng theo phương pháp SGA có tới 58,3% bệnh nhân bị SDD nhẹ, 2,2% bệnh nhân bị SDD nặng.
Posicionamiento del futuro. Un cambio de paradigma gracias a las implicaciones del "voice search"
Authors: Arganza Salcedo Raquel , Arroyo López Miriam 
Published: July 2021

Este trabajo ha obtenido el Premio Estudios Financieros 2019 en la modalidad de Marketing y Publicidad.
Dentro de sus múltiples aplicaciones, las búsquedas por voz han cobrado gran importancia en relación con el posicionamiento en internet al cambiar la forma en la que se presenta el contenido y se busca información.
En este estudio, se analiza el concepto de voice search, sus principales características y las aplicaciones más utilizadas. Se realiza una investigación en profundidad sobre las repercusiones de las búsquedas por voz que se ha dividido en dos partes: la primera, estudia la repercusión de la voz en el contenido actual dentro del posicionamiento orgánico; en la segunda, se plantean nuevos modelos de publicidad por voz que sustituyan al actual pago por clic y se lleva a cabo una estrategia de optimización dentro del sector cosmético para search enfocada a este tipo de búsquedas.
Las elecciones del año 2003 y la "difícil combinación" institucional
Authors: Artiga-González Álvaro 
Published: July 2021

En este trabajo, el autor hace una aproximación "institucionalista" a los desafíos que se plantean a los principales actores políticos del país, dado el resultado electoral del año 2003. Desde este punto de vista, ninguno de los partidos que gane las elecciones de 2004 tendrá, por sí mismo, una mayoría legislativa que le permita gobernar. Ello planteará la necesidad de practicar una política de alianzas, entre las diversas fracciones de la Asamblea Legislativa, elegida en marzo de 2003. En realidad, se trata de una práctica que vienen realizando los partidos ARENA y PCN, desde los años ochenta del siglo pasado. Un probable gobierno de izquierda también tendrá que recurrir a la práctica de alianzas amplias preelectorales y postelectorales. Así lo exige el diseño salvadoreño de las instituciones políticas, el cual combina: el presidencialismo con el multipartidismo. La representación proporcional y un alto nivel de polarización vuelven aún más difícil esta combinación. La investigación polirológica comparativa hecha sobre los casos latinoamericanos sugiere que la única forma de evitar las crisis institucionales, dada esta "difícil combinación", es mediante la constitución de gobiernos de coaliciones mayoritarias.
ECA Estudios Centroamericanos, Vol. 58, No. 653-654, 2003: 213-238.
Elecciones 2003
Authors: Alvarenga Luis , Rivas Jaime , Rodríguez Rommel , Zepeda Carlos 
Published: July 2021

En las siguientes líneas se hace una aproximación general a las posibles implicaciones sociales, económicas y regionales de los resultados de las pasadas elecciones y a los probables escenarios que se generarían, en el ámbito legislativo y municipal, durante los próximos tres años. Los autores sostienen que no cabe esperar mayores modificaciones en el corto plazo, en respuesta a que la correlación de fuerzas en el seno legislativo permaneció intacta, a la proximidad de los comicios presidenciales y a la distribución del poder municipal. En cualquier caso, se avizoran intensos debates entre las fracciones legislativas mayoritarias, cuyos resultados incidirán en el avance, estancamiento o retroceso de cuestiones de interés social, económico y de alcance regional como el tratado de libre comercio con Estados Unidos, el Plan Puebla-Panamá y el Área de Libre Comercio de las Américas.
ECA Estudios Centroamericanos, Vol. 58, No. 653-654, 2003: 277-293.
Construir la paz
Authors: Suira Arcinio 
Published: July 2021

En este artículo, el autor reflexiona sobre el problema de la paz, en un pais en donde el principal obstáculo cultural para apropiarnos de las posibilidades de convivencia padfica es la creencia de que las relaciones pacíficas son utopía en El Salvador. Precisamente, las relaciones conflictivas se nos presentan cada día como realidad ineludible y son las que nos han motivado a reflexionar sobre la paz como un problema. Esta reflexión, por muy teórica que pueda parecer, es urgente, ya que en la medida en que tengamos no solo claridad, sino también argumentos sólidos para fundamentar y orientar nuestras acciones, de ese mismo modo nuestra cosecha en el campo de la construcción de paz será mayor a largo plazo. El acrual contexto mundial, donde el viejo adagio latino, "si quieres paz, prepárate para la guerra", está siendo puesto en acción, en la llamada guerra contra el terrorismo, nos invita también a reflexionar sobre la paz. Ojalá que esta reflexión ayude a darle un giro a la lógica contradictoria de este adagio latino y a tomar concienciade que si queremos la paz, tenemos que prepararnos para la paz.
ECA Estudios Centroamericanos, Vol. 58, No. 655, 2003: 401-413.
FRENCH PROTESTANTISM AND ITS AMBIVALENT ATTITUDE TOWARD CULTURE
Authors: Wells Paul 
Published: July 2021

Protestantism in France has an ambiguous attitude to the surrounding culture, because of its position as a small minority. The other forces present are Roman Catholic authoritarianism and the liberal free-thinking of Enlightenment humanism, represented by the likes of Voltaire and Rousseau. The paradox is that since the Revolution in 1789, which was anti-royal and anti-religious, when Protestantism has sided with the majority Roman Church it has undermined its Reformed identity, and when it has sided with libertarian free-thinking it has undermined its Christian identity. This remains a feature of French Protestantism until the present day. As a result of this tension, the thought of one of France’s greatest thinkers, John Calvin, became virtually unknown, not only in French culture and society as a whole, but also within French Protestantism itself.
KEYWORDS: Protestant, Reformed, French, Catholic