bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der Arnulfparksteg – Glas als Berührungsschutz und Gestaltungselement
Authors: Siebert Barbara , Herrmann Tobias 
Published: October 2021

AbstractDie Fuß‐ und Radwegbrücke Arnulfpark quert alle 37 Bahngleise im Bereich zwischen Hacker‐ und Donnersbergerbrücke in München. Der Überbau mit veränderlichem Querschnitt aus Stahl wurde 2018 und 2019 im Taktschiebe‐Verfahren erstellt. Die Montage der Berührschutzverglasung erfolgte im Anschluss – noch vor dem Abstapeln des Überbaus in die endgültige Position. Die streifenförmig bedruckten Verglasungen füllen die rechteckigen Öffnungen zwischen Ober‐ und Untergurt. Sie sind linien‐ und punktförmig gehalten und zur Brückenachse hin geneigt, sodass neben den Anforderungen an die Stoßsicherheit nach DIN 18008‐4 auch der Nachweis der Resttragfähigkeit zu erfüllen sind. Aufgrund der Abweichungen zu den technischen Regeln wurde eine Zustimmung im Einzelfall beantragt, welche auf Basis entsprechender Bauteilversuche und einer gutachterlichen Stellungnahme erteilt wurde. Entlang der Verbindungstreppen zu zwei S‐Bahnsteigen und an einer benachbarten Lärmschutzwand wurden weitere großformatige, punktförmig gelagerte Verglasungen verbaut. Bei der statischen Berechnung war unter anderem der Lastfall Zugvorbeifahrt zu berücksichtigen.The Arnulfpark Bridge – Glass as contact protection and design element. The foot and bicycle bridge Arnulfpark crosses all 37 railroad tracks between Hacker‐ and Donners‐berger‐Bridge in Munich. The superstructure with its varying cross section made of steel was built by means of incremental launching method in 2018 and 2019. The installation of the contact protection glazing was carried out subsequently, but before destacking the superstructure to its final position. The strip‐shaped printed glazing fills the rectangular openings between top and bottom flange. It is linear and point supported and inclined towards the bridge axis. Therefore, in addition to the requirements for impact resistance according to DIN 18008‐4, the verification of the residual load‐bearing capacity must also be fulfilled. Due to the deviations from the technical rules, a special building permit was requested, which was granted on the basis of pendelum impact tests and an expert's opinion. Along the connecting stairs to two S‐Bahn platforms and on an adjacent noise barrier, further large‐format, point supported glazing was installed. In the static calculation, the load case train pass‐by had to be considered among other things.
Glassphäre für das Academy Museum of Motion Pictures
Authors: Schmitt Felix , Zimmermann Stefan 
Published: October 2021

AbstractIn Los Angeles soll der neue Gebäudekomplex „Academy Museum of Motion Pictures“ im Dezember 2019 eröffnet werden. Für Ausstellungsflächen wird hierzu das historische „May Company Building“ renoviert und über mehrere verglaste Fußgängerbrücken mit einem sphärischen Kinoneubau verbunden. Für die Gesamtplanung sind die renommierten Architekturbüros „Renzo Piano Building Workshop“ und M. Arthur Gensler Jr. & Associates verantwortlich. Im Artikel wird die Planung, Fertigung und Montage der erdbebensicheren Stahl‐/Glaskonstruktionen der Brücken und der Kuppel über dem Kino beschrieben. Eine Besonderheit stellt auch das sphärische Glasdach mit einem Durchmesser von 46 m dar. Die Stahlstruktur folgt verschiedenen geometrischen Vorgaben.Glass sphere for the Academy Museum of Motion Pictures. In Los Angeles, the new building complex “Academy Museum of Motion Pictures” is to be opened in December 2019. The historic “May Company Building” is redesigned as an exhibition space and connected to a new spherical theater building via several glazed pedestrian bridges. The renowned architects Renzo Piano Building Workshop and M. Arthur Gensler Jr. & Associates are responsible for the overall planning. The article describes the design, fabrication and installation of the earthquake‐proof steel/glass structures of the bridges and the dome above the theater. Another special feature is the free‐span spherical glass roof with a diameter of 46 m. The steel structure is following different geometrical rules.
Möglichkeiten und Verantwortung durch überarbeitete Teile 1 und 2 der DIN 18008
Authors: Siebert Geralt 
Published: October 2021

AbstractNach der Veröffentlichung einer zweiten Entwurfsfassung für die überarbeiteten Teile 1 und 2 der DIN 18008 wird eine Endfassung für Januar 2020 erwartet. Die Überarbeitung der Teile 3–5 hat begonnen. Die Hintergründe der Änderungen von Teil 1 und 2 – insbesondere der zuletzt vorgenommenen und intensiv diskutierten Änderungen – sowie zwischenzeitlich erarbeitete Hilfsmittel für eine zukünftige Anwendung werden dargestellt. Bauartspezifische Anforderungen erlauben, in Übereinstimmung mit (europäischer) Bauproduktverordnung, Planenden, die nationalen Anforderungen an Baukonstruktionen umsetzen zu können. Ein Ausblick auf die parallel laufende Normung auf europäischer Ebene vervollständigt das Bild.Opportunities and responsibility resulting in updated DIN 18008. After the publication of a second draft version for the revised parts 1 and 2 of DIN 18008, a final version is expected for January 2020, the revision of parts 3–5 has begun. The background to the amendments to Parts 1 and 2 – in particular to the most recent and intensively discussed amendments – as well as the aids developed in the meantime for future application are presented. Type‐specific requirements allow planners to implement the national requirements for building constructions in accordance with the (European) Construction Product Ordinance. An outlook on parallel ongoing standardization work at the European level completes the picture.
Semi‐probabilistische Bemessung tragender Silikonverklebungen mit Teilsicherheitsbeiwerten
Authors: Drass Michael , Kraus Michael A. 
Published: October 2021

AbstractZur Dimensionierung geklebter Silikonbauteile wird gemäß ETAG 002 ein globaler Sicherheitsbeiwert von 6 gefordert. Die Hintergründe dieses Sicherheitsfaktors sind nicht näher bekannt, allerdings gelten neben materiellen Unsicherheiten auch Modellierungsfehler infolge einfachster Berechnungsverfahren als ausreichend abgedeckt. Neueste Erkenntnisse auf dem Gebiet der experimentellen und numerischen Modellierung tragender Silikonverklebungen erlauben ein besseres mechanisches Verständnis und damit die Bestimmung realitätsnaher Versagenslasten. In diesem Beitrag werden Eurocode‐konforme Teilsicherheitsbeiwerte für tragende Silikonverklebungen semi‐probabilistisch hergeleitet und an zugehörigen experimentellen Daten für das DOWSIL 993 Silikon kalibriert.Semi‐probabilistic design of structural silicone sealings using partial safety factors. In accordance with ETAG 002, a global safety factor of 6 is required for the dimensioning of bonded silicone components. The background to this safety factor is not known in detail, but in addition to material uncertainties, modelling errors due to the simplest calculation methods are also considered to be sufficiently covered. The latest findings in the field of experimental and numerical modelling of load‐bearing silicone bondings allow a better mechanical understanding and thus the determination of realistic failure loads. In this contribution, Eurocode‐compliant partial safety factors for load‐bearing silicone adhesives are derived semi‐probabilistically and calibrated for a DOWSIL 993 silicone using the corresponding experimental data.
Polymere Werkstoffe im konstruktiven Glasbau – Vorschläge zur nichtlinearen Berechnung
Authors: Scherer Christian , Scherer Thomas , Schwarz Thomas , Wittwer Wolfgang , Semar Ernst 
Published: October 2021

AbstractSchon seit jeher besteht ein großes Interesse, das Verhalten von Bauwerken und Konstruktionen vorauszubestimmen. Zur Vorhersage des Verhaltens bedienen wir uns dabei neben experimentellen Versuchen zunehmend auch der meist zeit‐ und kostengünstigeren rechnerischen Simulationen. Die Finite‐Element‐Methode (FEM) ist ein Verfahren, welches sich dabei zunehmend durchgesetzt hat und seit Jahrzehnten im Flug‐ und Fahrzeugbau fest etabliert ist. In den letzten Jahren werden numerische Simulationen auch verstärkt zur Überprüfung von Klebeverbindungen eingesetzt. Speziell in der Fassade gewinnen polymere Werkstoffe wie bspw. Dichtstoffe oder thermoplastische Abstandhalter immer mehr an Bedeutung. Diese unterscheiden sich bzgl. ihres Dehnspannungsverhaltens stark vom klassisch linearen Verhalten etablierter Materialien wie Aluminium, Stahl oder Glas. Die vorliegende Arbeit verwendet nicht‐lineare Materialgesetze zur FEM‐Simulation und zeigt an diversen Projekten das Verhalten der Klebefuge in verschiedenen Belastungsszenarien.Nonlinear calculation methods for polymeric materials in structural glass construction – an overview. Since ever a strong interest in foreseeing the behavior of buildings and constructions exists. In order to predict the behavior, we use experiments as well as increasingly the usually more time‐ and cost‐effective computational simulations. The Finite Element Analysis (FEA) is a method that has become increasingly prevalent and has been firmly established in aviation and vehicle construction for decades. In recent years, numerical simulations are also increasingly used for the verification of adhesive bonds. Especially in the facade, polymeric materials such as sealants or thermoplastic spacers are becoming increasingly important. With regard to their expansion stress behavior, these differ strongly from the classic linear behavior of established materials such as aluminum, steel or glass. The present work uses non‐linear material laws for FEA and exhibits the behavior of the sealant joint in various load scenarios on several projects.
Late‐Stage Amination of Drug‐Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium‐Catalyzed C−H Activation
Authors: Weis Erik , Johansson Magnus J. , Martín‐Matute Belén 
Published: October 2021

AbstractThe functionalization of C−H bonds, ubiquitous in drugs and drug‐like molecules, represents an important synthetic strategy with the potential to streamline the drug‐discovery process. Late‐stage aromatic C−N bond–forming reactions are highly desirable, but despite their significance, accessing aminated analogues through direct and selective amination of C−H bonds remains a challenging goal. The method presented herein enables the amination of a wide array of benzoic acids with high selectivity. The robustness of the system is manifested by the large number of functional groups tolerated, which allowed the amination of a diverse array of marketed drugs and drug‐like molecules. Furthermore, the introduction of a synthetic handle enabled expeditious access to targeted drug‐delivery conjugates, PROTACs, and probes for chemical biology. This rapid access to valuable analogues, combined with operational simplicity and applicability to high‐throughput experimentation has the potential to aid and considerably accelerate drug discovery.
A game model for information dissemination in live streaming e‐commerce environment
Authors: Lv Junjie , Yao Wenjing , Wang Yuanzhuo , Wang Zichen , Yu Jianye 
Published: October 2021

SummaryAs a new form of social e‐commerce, live streaming e‐commerce is becoming increasingly popular among Chinese consumers. Live streaming brings huge opportunities, and we can take measures to further expand the dissemination of live streaming information. A live streaming information dissemination game model based on social evolutionary game theory is presented to simulate multiple complex live streaming e‐commerce networks. The introduction of incentive mechanism in the model further quantifies the internal relation between rewards and live streaming information dissemination to a certain extent and predicts the ratings of live streaming in networks with different update frequency of social relationships. The simulation results indicate that the reputation environment in social networks, adjusting frequency of relationship, pre‐broadcast rewards to post‐broadcast rewards ratio all have certain ranges of impact on information dissemination in live streaming e‐commerce environment and then affect the live streaming ratings. These findings offer insights into the dissemination of live streaming information in social networks.
Enhanced electron transfer dynamics in perylene diimide passivated efficient and stable perovskite solar cells
Authors: Wang Shihuai , Wu Tai , Qiu Junming , Wang Runtao , Zhu Zhongqi , Zhang Xiaoliang , Hua Yong 
Published: October 2021

AbstractInterfacial engineering for passivating perovskite surface defects and reducing nonradiative recombination loss has been proven to be an effective strategy to fabricate highly efficient and stable perovskite solar cells (PSCs). However, the detailed understanding of the original role of interface materials on the charge‐carriers transfer dynamics of electron transport layer (ETL) remains lacking. Herein, a perylene diimide (PDI) was engineered onto perovskite surfaces to afford passivation of undercoordinated surface defects, which correlates this with the improvement of photovoltaic performance and stability of PSCs. Extensively experimental and theoretical studies reveal that PDI molecule can effectively modulate the surface properties of perovskite film through not only interaction of carbonyl groups in PDI with surface defects but also formation of close‐packed superstructure of PDI onto perovskite surfaces. Consequently, the PDI‐treated PSCs exhibits an increase of power conversion efficiency from 19.52% to 22.24% with an excellent stable device maintaining 95% of its initial value for 900 h in ~45% relative humidity. Importantly, transient absorption spectroscopic measurements further provide an evidence for the origin of the improved photovoltaic performance in PDI‐treated PSCs device, in which the modulation of PDI enhanced the electron transfer across ETL interface more efficiently. Our study provides new insights to understand the effect of interfacial material on the charge‐carrier transfer dynamics in PSCs device.image
Poor survival and prediction of prolonged isolated thrombocytopenia post umbilical cord blood transplantation in patients with hematological malignancies
Authors: Wu Yue , Zhang Zhidan , Tu Meijuan , Pan Tianzhong , Ding Peng , Tang Baolin , Wan Xiang , Yao Wen , Song Kaidi , Sun Guangyu , Geng Liangquan , Qiang Ping , Liu Huilan , Zhu Xiaoyu , Sun Zimin 
Published: October 2021

AbstractProlonged isolated thrombocytopenia (PIT) is a common complication after umbilical cord blood transplantation (UCBT). However, data on PIT prediction and impacts on transplantation outcomes for UCBT patients are rare. We retrospectively analyzed 244 patients with hematological malignancies who received single‐unit UCBT at the First Affiliated Hospital of USTC between August 2018 and December 2019. Among them, PIT occurred in 49 recipients, with a crude incidence of 20.1%. In the PIT patients, the 2‐year cumulative incidence of transplant‐related mortality (TRM) was significantly higher, and the probabilities of 2‐year overall survival, leukemia‐free survival and graft‐versus‐host disease (GVHD)‐free relapse‐free survival were significantly poorer (57.1% vs. 88.6%; 53.1% vs. 81.9%; 22.4% vs. 59.8%; p < 0.001), without remarkable increases in the cumulative incidence of relapse or chronic GVHD. Importantly, the multivariate analysis revealed that lower high‐resolution HLA compatibility (≤6/10), lower infused CD34+ cell count (≤1.78 × 105/kg), grade II–IV acute GVHD preplatelet engraftment, a lower pretransplantation platelet count (≤100 × 109/L), and a longer neutrophil engraftment time (≥17 days) were independent risk factors for PIT after UCBT. These results demonstrate that PIT is common after UCBT, predicting inferior survival and the need for more monitoring during the early phase.
Impacts of different thermal modes of multiple obstacles on the hydrothermal analysis of Fe3O4–water nanofluid enclosed inside a nonuniformly heated cavity
Authors: Acharya Nilankush 
Published: October 2021

AbstractHeat transfer enrichment is significant because its optimum values lead to the optimal usage of energy resources and further improvement of energy efficiency. The obstacles inside an enclosure can successfully control hydrothermal variations. Also, the nanofluid inside the enclosure can foster heat transport. With this aim, the current investigation addresses the hydrothermal analysis of water‐based ferrous (Fe3O4) nanofluidic motion within a square compartment. The left‐sided and lowermost boundaries of the enclosure are imagined to be nonuniformly heated, whereas the right‐sided boundary is treated as isothermally cooled and the upper surface is made insulated. Diamond‐shaped multiple obstacles are organized inside the chamber to detect the hydrothermal transition. Additionally, both magnetic effect and thermal radiation presence are presumed. A complete analysis explores how the different heated conditions of the arranged multiple obstacles affect the hydrothermal characteristics. After reducing the dimensional equations into their dimensionless form via an accurate similarity conversion, the transformed equations are solved using the Galerkin finite element procedure. The experimental validation, comparison test, and grid independence are executed to enlighten us on the precision of the model presented. The parametric investigation includes various plots of streamlines, velocity distribution, and isotherms for Rayleigh number , thermal radiation , nanoparticle volume fraction , and Hartmann number . The outcomes show the enhanced bouncy‐driven convection for the Rayleigh number, whereas such an effect declines for the magnetic field. The average Nusselt number escalates for Rayleigh number and nanoparticles concentration, but cold obstacles render the highest magnitude compared with other obstacles.
Modeling of the fired preheater of crude oil considering the effect of geometrical parameters on fuel consumption
Authors: Mostafavi Seyed Alireza , Rezaei Ali 
Published: October 2021

AbstractProminent equipment with a very high demand for fuels in refineries is the fired preheater of crude oil. There are two main reasons to investigate the energy usage of such fired heaters. First, this is essential to the economic value of the refinery process unit and second, this is located at the beginning of the process line, which causes inefficient performance or damage in downstream equipment if it is not tuned properly. This paper concentrates on the thermal modeling of a fired heater of crude oil to evaluate the effect of influential parameters on fuel consumption. As the number of variables is markedly high, and considering the complexity of thermal modeling, all equations in a code yield predefined heater efficiency. Results from the model show that the increase in heater size yields a decrease in efficiency. It was also found that with a constant dimension of the fired heater, change in the number of pipes is much less influential rather than more inexpensive ideas like increasing speed of the burning gas on reduction of the fuel consumption. In other words, it was found that a distance of 500–650 mm from the center to the center distance of the pipes is the optimal distance to reduce fuel consumption.
Cancer of the ovary, fallopian tube, and peritoneum: 2021 update
Authors: Berek Jonathan S. , Renz Malte , Kehoe Sean , Kumar Lalit , Friedlander Michael 
Published: October 2021

AbstractIn 2014, FIGO’s Committee for Gynecologic Oncology revised the staging of ovarian cancer, incorporating ovarian, fallopian tube, and peritoneal cancer into the same system. Most of these malignancies are high‐grade serous carcinomas (HGSC). Stage IC is now divided into three categories: IC1 (surgical spill); IC2 (capsule ruptured before surgery or tumor on ovarian or fallopian tube surface); and IC3 (malignant cells in the ascites or peritoneal washings). The updated staging includes a revision of Stage IIIC based on spread to the retroperitoneal lymph nodes alone without intraperitoneal dissemination. This category is now subdivided into IIIA1(i) (metastasis ≤10 mm in greatest dimension), and IIIA1(ii) (metastasis >10 mm in greatest dimension). Stage IIIA2 is now “microscopic extrapelvic peritoneal involvement with or without positive retroperitoneal lymph node” metastasis. This review summarizes the genetics, surgical management, chemotherapy, and targeted therapies for epithelial cancers, and the treatment of ovarian germ cell and stromal malignancies.
Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice
Authors: Desai Varsha G. , Vijay Vikrant , Han Tao , Moland Carrie L. , Phanavanh Bounleut , Lee Taewon , Davis Kelly J. , Muskhelishvili Levan , Stine Kimo C. , Fuscoe James C. 
Published: October 2021

AbstractSubclinical cardiotoxicity at low total cumulative doxorubicin (DOX) doses can manifest into cardiomyopathy in long‐term cancer survivors. However, the underlying mechanisms are poorly understood. In male B6C3F1 mice, assessment of cardiac function by echocardiography was performed at 1, 4, 10, 17, and 24 weeks after exposure to 6, 9, 12, and 24 mg/kg total cumulative DOX doses or saline (SAL) to monitor development of delayed‐onset cardiotoxicity. The 6‐ or 9‐mg/kg total cumulative doses resulted in a significant time‐dependent decline in systolic function (left ventricular ejection fraction (LVEF) and fractional shortening (FS)) during the 24‐week recovery although there was not a significant alteration in % LVEF or % FS at any specific time point during the recovery. A significant decline in systolic function was elicited by the cardiotoxic cumulative DOX dose (24 mg/kg) during the 4‐ to 24‐week period after treatment compared to SAL‐treated counterparts. At 24 weeks after DOX treatment, a significant dose‐related decrease in the expression of genes and proteins involved in sarcoplasmic reticulum (SR) calcium homeostasis (Ryr2 and Serca2) was associated with a dose‐related increase in the transcript level of Casp12 (SR‐specific apoptosis) in hearts. These mice also showed enhanced apoptotic activity in hearts indicated by a significant dose‐related elevation in the number of apoptotic cardiomyocytes compared to SAL‐treated counterparts. These findings collectively suggest that a steady decline in SR calcium handling and apoptosis might be involved in the development of subclinical cardiotoxicity that can evolve into irreversible cardiomyopathy later in life.
Analysis in silico of chemical reactivity employing the local hyper‐softness in some classic aromatic compounds, boron aromatic clusters and all‐metal aromatic clusters
Authors: Martínez‐Araya Jorge I. , Islas Rafael 
Published: October 2021

AbstractIn the current work, the authors analyzed and compared the chemical behavior of some (anti)aromatic compounds. The species selected are benzene and cyclobutadiene as the aromatic and antiaromatic classical examples, respectively. Next, the anion , which is the first all‐metal molecule catalogued as aromatic and its non‐metallic isoelectronic analog, were also analyzed. The antiaromatic clusters and were studied in form of lithium salts. And the end, the non‐planar boron cluster and its isoelectronic analogs ( and ) were considered for being analyzed under the same criterium. The analysis was realized employing the following descriptors: molecular electrostatic potential and local hyper‐softness to get insights concerning local reactivity when facing reagents leading to ionic or covalent interactions. The results show that all the molecules analyzed presented some specific variations in their respective local reactivity despite being labeled as aromatic compounds. This analysis provides a notion that the local reactivity is more based on the nature of the atoms and the molecular geometry than the aromatic character by itself.