bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulatory Response to Rapid Volume Expansion and Cardiorespiratory Fitness in Fontan Circulation
Authors: Möller Thomas , Klungerbo Vibeke , Diab Simone , Holmstrøm Henrik , Edvardsen Elisabeth , Grindheim Guro , Brun Henrik , Thaulow Erik , Köhn-Luque Alvaro , Rösner Assami , Døhlen Gaute 
Published: December 2021

AbstractThe role of dysfunction of the single ventricle in Fontan failure is incompletely understood. We aimed to evaluate hemodynamic responses to preload increase in Fontan circulation, to determine whether circulatory limitations in different locations identified by experimental preload increase are associated with cardiorespiratory fitness (CRF), and to assess the impact of left versus right ventricular morphology. In 38 consecutive patients (median age = 16.6 years, 16 females), heart catheterization was supplemented with a rapid 5-mL/kg body weight volume expansion. Central venous pressure (CVP), ventricular end-diastolic pressure (VEDP), and peak systolic pressure were averaged for 15‒30 s, 45‒120 s, and 4‒6 min (steady state), respectively. CRF was assessed by peak oxygen consumption (VO2peak) and ventilatory threshold (VT). Median CVP increased from 13 mmHg at baseline to 14.5 mmHg (p < 0.001) at steady state. CVP increased by more than 20% in eight patients. Median VEDP increased from 10 mmHg at baseline to 11.5 mmHg (p < 0.001). Ten patients had elevated VEDP at steady state, and in 21, VEDP increased more than 20%. The transpulmonary pressure difference (CVP‒VEDP) and CVP were consistently higher in patients with right ventricular morphology across repeated measurements. CVP at any stage was associated with VO2peak and VT. VEDP after volume expansion was associated with VT. Preload challenge demonstrates the limitations beyond baseline measurements. Elevation of both CVP and VEDP are associated with impaired CRF. Transpulmonary flow limitation was more pronounced in right ventricular morphology. Ventricular dysfunction may contribute to functional impairment after Fontan operation in young adulthood.ClinicalTrials.govidentifier NCT02378857
The monofunctional CO dehydrogenase CooS is essential for growth of Thermoanaerobacter kivui on carbon monoxide
Authors: Jain Surbhi , Katsyv Alexander , Basen Mirko , Müller Volker 
Published: December 2021

AbstractThermoanaerobacter kivui is a thermophilic acetogen that can grow on carbon monoxide as sole carbon and energy source. To identify the gene(s) involved in CO oxidation, the genome sequence was analyzed. Two genes potentially encoding CO dehydrogenases were identified. One, cooS, potentially encodes a monofunctional CO dehydrogenase, whereas another, acsA, potentially encodes the CODH component of the CODH/ACS complex. Both genes were cloned, a His-tag encoding sequence was added, and the proteins were produced from a plasmid in T. kivui. His-AcsA copurified by affinity chromatography with AcsB, the acetyl-CoA synthase of the CO dehydrogenase/acetyl CoA synthase complex. His-CooS copurified with CooF1, a small iron-sulfur center containing protein likely involved in electron transport. Both protein complexes had CO:ferredoxin oxidoreductase as well as CO:methyl viologen oxidoreductase activity, but the activity of CooSF1 was 15-times and 231-times lower, respectively. To underline the importance of CooS, the gene was deleted in the CO-adapted strain. Interestingly, the ∆cooS deletion mutant did not grow on CO anymore. These experiments clearly demonstrated that CooS is essential for growth of T. kivui on CO. This is in line with the hypothesis that CooS is the CO-oxidizing enzyme in cells growing on CO.
A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue
Authors: Petr Jan , Hogeboom Louise , Nikulin Pavel , Wiegers Evita , Schroyen Gwen , Kallehauge Jesper , Chmelík Marek , Clement Patricia , Nechifor Ruben E. , Fodor Liviu-Andrei , De Witt Hamer Philip C. , Barkhof Frederik , Pernet Cyril , Lequin Maarten , Deprez Sabine , Jančálek Radim , Mutsaerts Henk J. M. M. , Pizzini Francesca B. , Emblem Kyrre E. , Keil Vera C. 
Published: December 2021

AbstractCancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning.This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research.
Determinants of home care utilization among the Swedish old: nationwide register-based study
Authors: Brändström Anders , Meyer Anna C. , Modig Karin , Sandström Glenn 
Published: December 2021

AbstractSince the 1990s, Sweden has implemented aging-in-place policies increasing the share of older adults dependent on home care instead of residing in care homes. At the same time previous research has highlighted that individuals receive home care at a higher age than before. Consequently, services are provided for a shorter time before death, increasing reliance on family and kin as caregivers. Previous studies addressing how homecare is distributed rely primarily on small surveys and are often limited to specific regions. This study aims to ascertain how home care services are distributed regarding individual-level factors such as health status, living arrangements, availability of family, education, and socioeconomic position. To provide estimates that can be generalized to Sweden as a whole, we use register data for the entire Swedish population aged 65 + in 2016. The study's main findings are that home care recipients and the amount of care received are among the oldest old with severe co morbidities. Receiving home care is slightly more common among women, but only in the highest age groups. Childlessness and socioeconomic factors play a small role in who receives home care or not. Instead, the primary home care recipients are those older adults living alone who lack direct support from family members residing in the same household.
Dual-Factor Mental Health from Childhood to Early Adolescence and Associated Factors: A Latent Transition Analysis
Authors: Petersen Kimberly J. , Humphrey Neil , Qualter Pamela 
Published: December 2021

AbstractThe dual-factor model of mental health indicates the importance of simultaneously assessing symptoms and subjective wellbeing, but there is limited understanding of how dual-factor mental health changes during the transition from childhood to early adolescence and factors associated with change. The current study investigated dual-factor mental health over a 2-year period from when children were 8–9 years old to 10–11 years old (N = 2402; 48% female), using latent transition analysis. Further analyses determined whether sex and peer support were associated with initial mental health status or specific transitions during this period. Following class enumeration procedures, a 5-class model was selected at both timepoints. Classes were: (1) complete mental health, (2) vulnerable, (3) emotional symptoms but content, (4) conduct problems but content, and (5) troubled. Half of the sample changed mental health status during the study period. Sex and peer support were associated with specific mental health statuses and subsequent transitions. The findings have implications for mental health screening practice and identifying those in need of targeted interventions.
Beyond the beaten paths of forecasting call center arrivals: on the use of dynamic harmonic regression with predictor variables
Authors: Rausch Theresa Maria , Albrecht Tobias , Baier Daniel 
Published: December 2021

AbstractModern call centers require precise forecasts of call and e-mail arrivals to optimize staffing decisions and to ensure high customer satisfaction through short waiting times and the availability of qualified agents. In the dynamic environment of multi-channel customer contact, organizational decision-makers often rely on robust but simplistic forecasting methods. Although forecasting literature indicates that incorporating additional information into time series predictions adds value by improving model performance, extant research in the call center domain barely considers the potential of sophisticated multivariate models. Hence, with an extended dynamic harmonic regression (DHR) approach, this study proposes a new reliable method for call center arrivals’ forecasting that is able to capture the dynamics of a time series and to include contextual information in form of predictor variables. The study evaluates the predictive potential of the approach on the call and e-mail arrival series of a leading German online retailer comprising 174 weeks of data. The analysis involves time series cross-validation with an expanding rolling window over 52 weeks and comprises established time series as well as machine learning models as benchmarks. The multivariate DHR model outperforms the compared models with regard to forecast accuracy for a broad spectrum of lead times. This study further gives contextual insights into the selection and optimal implementation of marketing-relevant predictor variables such as catalog releases, mail as well as postal reminders, or billing cycles.
Diagnostic Accuracy and Post-Procedural Complications Associated with Ultrasound-Guided Core Needle Biopsy in the Preoperative Evaluation of Parotid Tumors
Authors: Jering Monika , Mayer Marcel , Thölken Rubens , Schiele Stefan , Maccagno Andrea , Zenk Johannes 
Published: December 2021

AbstractCorrect diagnosis of a parotid neoplasm based on histology preoperatively is of utmost importance in order to guide patient management. The aim of this study was to evaluate the diagnostic accuracy of an ultrasound-guided core needle biopsy of a parotid lesion and to describe associated post-procedural complications. A retrospective study was conducted between January 2015 and March 2021 of all patients who were referred to a tertiary care center for evaluation of a parotid lesion and who underwent core needle biopsy due to high-risk features or when malignancy was suspected on clinical examination or ultrasonography. Patient characteristics, histological findings, and post-procedural complications were recorded and evaluated. Among 890 patients referred for evaluation of a parotid lesion, in 138 patients a core needle biopsy was undertaken. On the basis of core needle biopsy findings, 11 lymphomas and 82 non-lymphoma malignancies were diagnosed in the parotid gland. The sensitivity of the core needle biopsy predicting the accurate tumor type was 97.56% (95% CI 91.47–99.70%) and the specificity 94.64% (95% CI 85.13–98.88%). The accuracy for the correct histopathological diagnosis was 93.48% (95% CI 87.98–96.97%). Post-procedural minor complications occurred in 19 patients (13.8%). In conclusion, a core needle biopsy can identify malignancy in the parotid gland with high sensitivity and specificity in a safe manner and therefore guide surgical treatment.
Handling qualities of fixed-pitch, variable-speed multicopters for urban air mobility
Authors: Bahr M. , McKay M. , Niemiec R. , Gandhi F. 
Published: December 2021

AbstractOptimisation-based control design techniques are applied to multicopters with variable-RPM rotors. The handling qualities and motor current requirements of a quadcopter, hexacopter and octocopter with equal gross weights (5,360N) and total disk areas (producing a 287N/m$^2$disk loading) are compared in hover. For axes that rely on the rotor thrust (all except yaw), the increased inertia of the larger rotors on the quadcopter increase the current requirement, relative to vehicles with fewer, smaller rotors. Both the quadcopter and hexacopter have maximum current margin requirements (relative to hover) during a step command in longitudinal velocity. In yaw, rotor inertia is irrelevant, as the reaction torque of the motor is the same whether the rotor is accelerating or overcoming drag. This, combined with the octocopter’s greater inertia as well as the fact that it requires 30% less current to drive its motors in hover, results in the octocopter requiring the greatest current margin, relative to hover conditions. To meet handling qualities requirements, the total weight of the motors of the octocopter and hexacopter is comparable at 13.5% weight fraction, but the quadcopter’s motors are heavier, requiring 16% weight fraction. If the longitudinal and lateral axes were flown in ACAH mode, rather than TRC mode, the total motor weight of all configurations would be nearly identical, requiring about 13.5% weight fraction for motors (compared to 7–9% weight fraction from hover torque requirements).
What journalism tells us about memory, mind and media
Authors: Zelizer Barbie 
Published: December 2021

AbstractThis article looks to journalism in order to understand the relationship between memory, mind and media more fully. Using the urgency that characterises the current news environment as a reflection of broader information flows, the article considers journalism's embrace of complex time to address the demands of speed. It suggests that the temporal practices adopted by both individual journalists and the journalistic community offer a model for institutions wrestling with the ontological uncertainty generated by current times, providing mechanisms to navigate and even offset the unending demands of simultaneity, immediacy and instantaneity.
Selecting and averaging relaxed clock models in Bayesian tip dating of Mesozoic birds
Authors: Zhang Chi 
Published: December 2021

AbstractRelaxed clock models are fundamental in Bayesian clock dating, but a single distribution characterizing the clock variation is typically selected. Hence, I developed a new reversible-jump Markov chain Monte Carlo (rjMCMC) algorithm for drawing posterior samples between the independent lognormal (ILN) and independent gamma rates (IGR) clock models. The ability of the rjMCMC algorithm to infer the true model was verified through simulations. I then applied the algorithm to the Mesozoic bird data previously analyzed under the white noise (WN) clock model. In comparison, averaging over the ILN and IGR models provided more reliable estimates of the divergence times and evolutionary rates. The ILN model showed slightly better fit than the IGR model and much better fit than the autocorrelated lognormal (ALN) clock model. When the data were partitioned, different partitions showed heterogeneous model fit for ILN and IGR clocks. The implementation provides a general framework for selecting and averaging relaxed clock models in Bayesian dating analyses.
A Bias-Corrected Estimator for the Crosswise Model with Inattentive Respondents
Authors: Atsusaka Yuki , Stevenson Randolph T. 
Published: December 2021

AbstractThe crosswise model is an increasingly popular survey technique to elicit candid answers from respondents on sensitive questions. Recent studies, however, point out that in the presence of inattentive respondents, the conventional estimator of the prevalence of a sensitive attribute is biased toward 0.5. To remedy this problem, we propose a simple design-based bias correction using an anchor question that has a sensitive item with known prevalence. We demonstrate that we can easily estimate and correct for the bias arising from inattentive respondents without measuring individual-level attentiveness. We also offer several useful extensions of our estimator, including a sensitivity analysis for the conventional estimator, a strategy for weighting, a framework for multivariate regressions in which a latent sensitive trait is used as an outcome or a predictor, and tools for power analysis and parameter selection. Our method can be easily implemented through our open-source software cWise.
“No Pope Here”: Britain, the Vatican, the IRA, and the Papal Visit to Ireland, September 1979
Authors: Doherty Martin 
Published: December 2021

AbstractIt is often assumed, particularly by outsiders, that the conflict in Northern Ireland—known euphemistically as “the Troubles”—in which some 3,600 people lost their lives, was an atavistic throwback to Europe's religious wars of earlier centuries. In 1979, by which time some 2,000 people had already been killed in the Troubles, Pope John Paul II proposed to pay a visit to Ireland and perhaps to cross the border into Ulster's sectarian cockpit. The idea provoked outrage from some Ulster Protestants and high anxiety for the British, concerned that the Pope might inadvertently inflame the situation or embarrass the British by raising difficult issues. But there were hopes, too, that an unequivocal condemnation of violence by the head of the Catholic Church might help to bring the conflict to an end. This article, based on extensive research in diplomatic archives, reveals deep divisions within the Catholic Church on the Irish question and points to the power and limitations of the British diplomatic reach into the Vatican. It reveals also, however, the powerlessness of prayer and pleadings in the face of terrorist violence.
Differential heterologous neutralisation profile against strains within DENV-3 genotype II
Authors: Tan K.K. , Abubakar S. 
Published: December 2021

Abstract
The dengue virus type 3 (DENV-3) homotypic outbreak cycles reported in Klang Valley, Malaysia in 1992–1995 and 2002 demonstrated different epidemic magnitude and duration. These outbreak cycles were caused by two closely related strains of viruses within the DENV-3 genotype II (DENV-3/II). The role of viral genotypic diversity and factors that could have influenced this phenomenon were investigated. The serum neutralisation sensitivity of DEN3/II strains responsible for the DENV-3 outbreak cycles in 1992–1995 and 2002 were examined. Representative virus isolates from the respective outbreaks were subjected to virus neutralisation assay using identified sera of patients with homotypic (DENV-3) or heterotypic dengue infections (DENV-1 and DENV-2). Results from the study suggested that isolates representing DENV-3/II group E (DENV-3/II-E) from the 1992–1995 outbreak and DENV-3/II group F (DENV-3/II-F) from the 2002 outbreak were neutralised at similar capacity (intergenotypic differences <2-fold) by sera of patients infected with DENV-3, DENV-1 and DENV-2/Asian genotypes. Sera of the DENV-2/Cosmopolitan infection efficiently neutralised DENV-3/II-F (FRNT50 = 508.0) at a similar neutralisation capacity against its own homotypic serotype, DENV-2 (FRNT50 = 452.5), but not against DENV-3/II-E (FRNT50 = 100.8). The different neutralisation sensitivities of DENV-3/II strains towards the cross-reacting DENV-2 heterotypic immunity could play a role in shaping the DENV-3 recurring outbreaks pattern in Malaysia. Two genetic variations, E-132 (H/Y) and E-479 (A/V) were identified on the envelope protein of DENV-3/II-E and DENV-3/II-F, respectively. The E-132 variation was predicted to affect the protein stability. A more extensive study, however, on the implication of the naturally occurring genetic variations within closely related DENV genotypes on the neutralisation profile and protective immunity would be needed for a better understanding of the DENV spread pattern in a hyperendemic setting.
Childhood eating practices are relevant to ultra-processed food consumption in adulthood: results from the Nutritionists’ Health Study
Authors: Penha Sthefani da Costa , Norde Marina Maintinguer , Carioca Antonio Augusto Ferreira 
Published: December 2021

AbstractStudies on childhood feeding and current food consumption, according to the NOVA classification, in adults are scarce. The objective of this study was to evaluate the relationship between childhood dietary practices and the current consumption of different categories of processed foods in young adults using data from the Nutritionists’ Health Study (NutriHS) cohort. A cross-sectional analysis was performed using data of 392 on nutrition undergraduate students or nutritionists aged ≥18 years. Current food consumption was assessed using a food frequency questionnaire and the NOVA classification. The investigated childhood eating practices included fruit and vegetable intake, exclusive breastfeeding, and other breastfeeding practices. Participants breastfed with introduction of solid, semi-solid or soft foods before 6 months had higher current consumption of processed foods than those who were not breastfed (β = 4.30; 95% confidence interval [CI] = 0.56–8.04) and those who did not have the habits of eating fruits and vegetables during childhood consumed less unprocessed and minimally processed foods in adulthood than those who ate fruits and vegetables during infancy (β = −3.76; 95% CI = −0.82 to −6.70). Further, later introduction of infant formula or other types of milk between 3 and 5 months of age had a lower current consumption of ultra-processed foods than those fed infant formula or other types of milk before 1 month age of life (β = −3.09; 95% CI = −6.12 to −0.06). In conclusion, childhood feeding practices were linked to food consumption in adult life in NutriHS cohort, highlighting that the first 1000 days of life seems to impact on food choices during adulthood, with potential to protect against nutrition-related diseases later in life.
Complex 3D Migration and Delayed Triggering of Hydraulic Fracturing‐Induced Seismicity: A Case Study Near Fox Creek, Alberta
Authors: Gao Dawei , Kao Honn , Wang Bei , Visser Ryan , Schultz Ryan , Harrington Rebecca M. 
Published: December 2021

AbstractEarthquakes resulting from hydraulic fracturing (HF) can have delayed triggering relative to injection commencement over a varied range of time scales, with the majority of M ≥ 4 mainshocks occurring near/after well completion. This poses serious challenges for risk mitigation and hazard assessment. Here, we document a high‐resolution, three‐dimensional source migration process with delayed mainshock triggering that is controlled by local hydrogeological conditions near Fox Creek, Alberta, Canada. Our results reveal that poroelastic effects might contribute to induced seismicity, but are probably insufficient to activate a large fault segment not critically stressed. The rapid pore‐pressure build‐up from HF can be very localized and capable of producing large, felt earthquakes if adequate hydrological paths exist. We interpret the delayed triggering as a manifestation of pore‐pressure build‐up along pre‐existing faults needed to facilitate seismic failure. Our findings can explain why so few injection operations are seismogenic.