bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a Novel Risk Score System of Immune Genes Associated With Prognosis in Esophageal Carcinoma
Authors: Fei Zhenghua , Xie Rongrong , Chen Zhi , Xie Junhui , Gu Yuyang , Zhou Yue , Xu Tongpeng 
Published: March 2021

BackgroundFew studies have addressed the role of immune-related genes in the survival and prognosis of different esophageal cancer (EC) sub-types. We established two new prognostic model indexes by bioinformatics analysis to select patients with esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) who may benefit from immunotherapy.MethodsBased on TCGA and ImmPort data sets, we screened immune genes differentially expressed between tumor and normal tissues in ESCC and EAC and analyzed the relationship between these genes and patient survival outcomes. We established the risk score models of immune-related genes in ESCC and EAC by multivariate COX regression analysis.ResultsWe identified 12 and 11 immune-related differentially expressed genes associated with the clinical prognosis of ESCC and EAC respectively, based on which two prognostic risk score models of the two EC sub-types were constructed. It was found that the survival probability of patients with high scores was significantly lower than that of patients with low scores (p &lt; 0.001). BMP1, EGFR, S100A12, HLA-B, TNFSF18, IL1B, MAPT and OXTR were significantly related to sex, TNM stage or survival outcomes of ESCC or EAC patients (p &lt; 0.05). In addition, the risk score of ESCC was significantly correlated with the level of B cell infiltration in immune cells (p &lt; 0.05).ConclusionsThe prognosis-related immune gene model indexes described herein prove to be useful prognostic biomarkers of the two EC sub-types in that they may provide a reference direction for looking for the beneficiaries of immunotherapy for EC patients.
Clinical and Molecular Differentiation Between Malignant Rhabdoid Tumor of the Kidney and Normal Tissue: A Two-Case Report
Authors: Zhanghuang Chenghao , Chen Shuo , Li Li , Yang Zhen , Xie Yucheng , Li Jiwei , Tang Haoyu , He Xiaoli , Dong Liuyi , Yan Bing 
Published: March 2021

BackgroundMalignant rhabdoid tumor of the kidney (MRTK) is a rare type of tumor that lacks typical clinical manifestations. Herein, we presented clinical data of 2 children with MRTK. In addition, we used a high-throughput RNA-sequencing (RNA-seq), GO analysis, and KEGG signaling pathway analysis to examine gene expression differences at the transcripts level between 2 patients with MRTK and 3 patients with non-tumor diseases without other symptoms.Case reportPreoperative B-scan ultrasonography and computed tomography (CT) examination in 2 cases suggested nephroblastoma. Both patients were treated with radical nephrectomy. After the operation, MRTK was confirmed by pathological examination. Child 1 and Child 2 then received 7 courses and 12 courses of regular chemotherapy, respectively. Child 1 was followed up for 2 years, and Child 2 for 3.1 years without showing symptoms. RNA-seq results showed 2203 differential genes (DEGs) in the kidney tissue of children with MRTK compared to normal tissue (p &lt;0.01). GO analysis suggested that most DEGs participate in protein binding. KEGG results showed that the DEGs were mainly involved in the PI3K-Akt signaling pathway and microRNA-related proteins.ConclusionThe PI3K-Akt signaling pathway and microRNA-related proteins as targets have extremely high potential value for the diagnosis and treatment of MRTK.
Perineural Invasion Is a Strong Prognostic Factor but Not a Predictive Factor of Response to Adjuvant Chemotherapy in Node-Negative Colon Cancer
Authors: Tu Junhao , Yao Zongxi , Wu Wenqing , Ju Jianxiang , Xu Yinkai , Liu Yulin 
Published: March 2021

PurposeTo validate the prognostic value and evaluate the predictive value of response to adjuvant chemotherapy of perineural invasion (PNI) in node-negative colon cancer using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) 18 tumor registry database.MethodsPatients diagnosed with colon cancer from the SEER database between January 1, 2010 and December 31, 2015 were identified. Chi-square analysis was performed to evaluate different demographic and clinical features of patients between PNI-negative (PNI (−)) and PNI-positive (PNI (+)) groups. Univariate and multivariate Cox proportional hazard regression models were built to examine the relationship of demographic and clinical features and survival outcomes with the hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsIn total, 57,255 node-negative colon cancer patients were extracted from the SEER database. The receipt of chemotherapy was not an independent prognostic factor for CSS in T3 colon cancer with or without the presence of PNI (P &gt;0.05). The receipt of chemotherapy was independently associated with 34.0% decreased risk of cancer-specific mortality compared with those without the receipt of chemotherapy in T4 colon cancer without the presence of PNI (HR = 0.660, 95%CI = 0.559–0.779, P &lt;0.001); the receipt of chemotherapy was independently associated with 36.0% decreased risk of cancer-specific mortality compared with those without the receipt of chemotherapy in T4 colon cancer with the presence of PNI (HR = 0.640, 95%CI = 0.438–0.935, P = 0.021).ConclusionsThe present study demonstrated the poor prognosis of PNI (+) in both stage I and II colon cancer. However, the presence of PNI was not a predictive factor of response to adjuvant chemotherapy in node-negative colon cancer.
One-Size-Fits All: A Scalable Solution to Formal Telemedicine Provider Training to Support the COVID-19 Pandemic Response
Authors: Schinasi Dana A. , An-Grogan Yuemi , Stephen Rebecca , Shimek Aric , Furney Marisa , Bohling M. Katie 
Published: March 2021

Introduction: Formalized training in telemedicine addresses barriers to provider adoption and engagement and assures a level of competence for independent practice. We previously developed a blended-model training program, customizable according to role and specialty; this method of training was not feasible in the pandemic response. We describe the development and implementation of a multi- and interdisciplinary telemedicine provider training program enabling the rapid scaling of telemedicine at our institution.Methods: An existing curriculum was pared down to a 1-h session delivered synchronously, covering the foundational components of telemedicine practice. Supplemental materials were available for asynchronous learning via the hospital intranet. Completion of training was required of all clinicians who practice telemedicine.Results: We conducted 35 sessions for 1,070 providers over 12 weeks. Attendees included clinicians across numerous roles and specialties. Additional resources were created and available through the Telemedicine Virtual Handbook and housed in specific toolkits.Discussion: Telemedicine training is necessary for consistent, competent practice of telemedicine in pediatrics. We describe a training process that can be easily replicated and rapidly deployed to providers of telemedicine across roles and disciplines. Combining a mandatory and brief synchronous provider training session with a repository of online resources creates a foundation for consistent practice, while allowing for more individualized resources accessible on demand. Standardized telemedicine training followed by mechanisms for ongoing professional practice evaluation allow institutions to ensure consistent and competent practice of telemedicine. Further study is needed to determine the best modality for training, and optimal assessment tools according to professional role.
ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation
Authors: McCann Anna , Vesin Jean-Marc , Pruvot Etienne , Roten Laurent , Sticherling Christian , Luca Adrian 
Published: March 2021

Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most likely to benefit from ablation, and (2) examine the temporal evolution of AF organization indices that could act as clinical indicators of ongoing ablation effectiveness and completeness.Method: Twelve-lead ECG was continuously recorded in 40 patients (61 ± 8 years) during stepwise CA (step-CA) procedures for treatment of pers-AF (sustained duration 19 ± 11 months). Following standard pre-processing, ECG signals were divided into 10-s epochs and labeled according to their temporal placement: pre-PVI (baseline), dur-PVI (during pulmonary vein isolation), and post-PVI (during complex-fractionated atrial electrograms and linear ablation). Instantaneous frequency (IF), adaptive organization index (AOI), sample entropy (SampEn) and f-wave amplitude (FWA) measures were calculated and analyzed during each of the three temporal steps. Temporal evolution of these measures was assessed using a statistical test for mean value transitions, as an indicator of changes in AF organization. Results were then compared between: (i) patients grouped according to step-CA outcome; (ii) patients grouped according to type of arrhythmia recurrence following the procedure, if applicable; (iii) within the same patient group during the three different temporal steps.Results: Stepwise CA patient outcomes were as follows: (1) left-atrium (LA) terminated, not recurring (LTN, n = 8), (2) LA terminated, recurring (LTR, n = 20), and (3) not LA terminated, all recurring at follow-up (NLT, n = 12). Among the LTR and NLT patients, recurrence occurred as AF in seven patients and atrial tachycardia or atrial flutter (AT/AFL) in the remaining 25 patients. The ECG measures indicated the lowest level of organization in the NLT group for all ablation steps. The highest organization was observed in the LTN group, while the LTR group displayed an intermediate level of organization. Regarding time evolution of ECG measures in dur-PVI and post-PVI recordings, stepwise ablation led to increases in AF organization in most patients, with no significant differences between the LTN, LTR, and NLT groups. The median decrease in IF and increase in AOI were significantly greater in AT/AFL recurring patients than in AF recurring patients; however, changes in the SampEn and FWA parameters were not significantly different between types of recurrence.Conclusion: Noninvasive ECG measures, though unable to predict arrhythmia recurrence following ablation, show the lowest levels of AF organization in patients that do not respond well to step-CA. Increasing AF organization in post-PVI may be associated with organized arrhythmia recurrence after a single ablation procedure.
Augmented Reality in Medical Practice: From Spine Surgery to Remote Assistance
Authors: Cofano Fabio , Di Perna Giuseppe , Bozzaro Marco , Longo Alessandro , Marengo Nicola , Zenga Francesco , Zullo Nicola , Cavalieri Matteo , Damiani Luca , Boges Daniya J. , Agus Marco , Garbossa Diego , Calì Corrado 
Published: March 2021

Background: While performing surgeries in the OR, surgeons and assistants often need to access several information regarding surgical planning and/or procedures related to the surgery itself, or the accessory equipment to perform certain operations. The accessibility of this information often relies on the physical presence of technical and medical specialists in the OR, which is increasingly difficult due to the number of limitations imposed by the COVID emergency to avoid overcrowded environments or external personnel. Here, we analyze several scenarios where we equipped OR personnel with augmented reality (AR) glasses, allowing a remote specialist to guide OR operations through voice and ad-hoc visuals, superimposed to the field of view of the operator wearing them.Methods: This study is a preliminary case series of prospective collected data about the use of AR-assistance in spine surgery from January to July 2020. The technology has been used on a cohort of 12 patients affected by degenerative lumbar spine disease with lumbar sciatica co-morbidities. Surgeons and OR specialists were equipped with AR devices, customized with P2P videoconference commercial apps, or customized holographic apps. The devices were tested during surgeries for lumbar arthrodesis in a multicenter experience involving author's Institutions.Findings: A total number of 12 lumbar arthrodesis have been performed while using the described AR technology, with application spanning from telementoring (3), teaching (2), surgical planning superimposition and interaction with the hologram using a custom application for Microsoft hololens (1). Surgeons wearing the AR goggles reported a positive feedback as for the ergonomy, wearability and comfort during the procedure; being able to visualize a 3D reconstruction during surgery was perceived as a straightforward benefit, allowing to speed-up procedures, thus limiting post-operational complications. The possibility of remotely interacting with a specialist on the glasses was a potent added value during COVID emergency, due to limited access of non-resident personnel in the OR.Interpretation: By allowing surgeons to overlay digital medical content on actual surroundings, augmented reality surgery can be exploited easily in multiple scenarios by adapting commercially available or custom-made apps to several use cases. The possibility to observe directly the operatory theater through the eyes of the surgeon might be a game-changer, giving the chance to unexperienced surgeons to be virtually at the site of the operation, or allowing a remote experienced operator to guide wisely the unexperienced surgeon during a procedure.
Hepatobiliyer Hastalıklarda Tanıya Yönelik Görüntüleme Yöntemlerinden Endoskopik Retrograd Kolanjiopankreatografi ve Manyetik Rezonans Kolanjiopankreatografinin Etkinliğinin Karşılaştırılması
Authors: BAYKAN Ahmed Ramiz , BURAN Tahir , GERÇEKER Emre , YÜCEYAR Hakan , TARHAN Serdar , KASAP Elmas , PEKİNDİL Gökhan 
Published: March 2021

Amaç: Manyetik rezonans kolanjiopankreatografinin tanıya yönelik etkinliğini tanıda altın standart olarak kabul edilen endoskopik retrograd kolanjiopankreatografi ile kıyaslayarak değerlendirmeyi planladık.
Gereç ve yöntem: Celal Bayar Üniversite hastanesi gastroenteroloji kliniğine 2012-2014 yılları arasında başvurup, Manyetik rezonans kolanjiopankreatografi ve sonrasında endoskopik retrograd kolanjiopankreatografi yapılan hastaların dosyaları retrospektif olarak incelendi
Bulgular: Çalışmaya 53 erkek, 57 kadın toplam 110 hasta dâhil edildi. Hastaların ortalama yaşı 63,56±16,897 olarak saptandı. Endoskopik retrograd kolanjiopankreatografi altın standart olarak alındığında ve kanülasyon sağlanamayan hastalar çıkarıldığında koledokolitizis için manyetik rezonans kolanjiopankreatografinin sensitivitesi (%66,6), spesifitesi (%82,8) olarak saptandı. Manyetik rezonans kolanjiopankreatografinin pozitif prediktif değeri (%86,9), negatif prediktif değeri (%59,1) olarak saptandı. 5 mm ve büyük taşlar dikkate alındığında, manyetik rezonans kolanjiopankreatografinin duyarlılığının %91,9’ a çıktığı görüldü. Hepatobiliyer malignitelerde, manyetik rezonans kolanjiopankreatografinin sensitivitesi (%69,56), spesifitesi (%100) olarak saptandı. Manyetik rezonans kolanjiopankreatografinin hepatobiliyer maligniteler için pozitif prediktif değeri (%100), negatif prediktif değeri (%91,13) olarak saptandı.
Sonuç: Hepatobiliyer hastalıkların tanısını koymada göstermiş olduğu yüksek sensitivite ve spesifite değerleri nedeni ile manyetik rezonans kolanjiopankreatografi, günümüzde tanı alanında endoskopik retrograd kolanjiopankreatografinin yerini büyük ölçüde almıştır. Teknolojinin gelişmesi ile birlikte daha iyi görüntü kalitesi sonucu tanı alanında bu etkinliğinin daha çok büyümesi beklenmektedir
Oztibarreko mintzoaz eta haren lexikoaz
Authors: Camino Lertxundi Iñaki 
Published: March 2021

Saioak hasieran Baxenabarreko euskaraz dagoen ikuspegi orokorra aurkezten du eta Hazparnek ezker-eskuin eta goi-behe hizkuntzaren aldetik ukan duen eraginaz proposamen bat egiten. Ondotik oztibartarren abeltzain-gizarteaz eta eskualdeko jendeen hartu-emanez ohar batzuk egiten dira. Hizkuntzaren atalean alderdi foniko eta morfosintaktikoez aurkezpen zabalxea egin da, non ageri baita Oztibarreko mintzoa Baxenabarreko erdigune-erdigunekoa dela, ez duela berezko ezaugarririk eta ondoko mintzoekin komunikazio-maila gora duela, nahiz badiren ekialde honetara heldu ez diren berrikuntza zenbait; bestalde, ahal izan den heinean hondarreko mendeetako hizkuntza-bilakabide batzuen berri ere eskaini da. Lexikoaz eta item lexikoen aldaera fonikoez egin den azterketak erakusten dituen bi lotura sendoenak, Garazi alderat eta Zuberoa alderat doazenak dira; Landibarren Baxenabarre mendebaleko euskararen eragin poxi bat ere ageri da. Oro har mintzo bateratuxea ageri zaigu Oztibarrekoa eta Garaziko eskualdean luke kiderik hurbilena.
La carta bilingüe de Matxin de Zalba (1416). El iceberg lingüístico navarro
Authors: Monteano Sorbet Peio 
Published: March 2021

La carta escrita en romance navarro y en euskera que en 1416 se intercambiaron dos altos funcionarios nos descubre una élite social y política de Navarra que conoce, habla y es capaz de escribir ambas lenguas y que utiliza ese bilingüismo como elemento de poder. Si el euskera no tuvo un uso escrito, no fue por falta de prestigio o por dificultades atribuibles a la propia lengua. La navarrización de la administración y de la corte desde comienzos del siglo XV fue en parte consecuencia del crecimiento demográfico de la población vascohablante, que pudo rondar el 80 por ciento de los navarros. Todo ello invita a reformular nuestra visión de la situación lingüística de Navarra y de la convivencia de ambas lenguas durante los últimos siglos de la Edad Media, utilizando la documentación, pero siendo conscientes también de sus limitaciones.
PEMETAAN DISTRIBUSI KANDUNGAN RADIOISOTOP DI DAERAH PERKEBUNAN UBI KAYU DI NUABOSI ENDE FLORES
Authors: Lake Yohanes Jean Del Rosario , Pasangka Bartholomeus , Tanesib Jehunias Leonidas 
Published: March 2021

ABSTRAK
Telah dilakukan penelitian di wilayah perkebunan ubi kayu Desa Ndetundora III Nuabosi Kecamatan Ende Kabupaten Ende mengenai pemetaan distribusi kandungan radioisotop. Tujuan penelitian ini menentukan interval cacah radiasi dan temperatur di daerah perkebunan, memetakan distribusi kandungan radiosotop di daerah perkebunan berdasarkan cacah radiasi dan temperatur serta mengestimasi luas daerah yang cacah radioisotopnya cukup tinggi. Metode penelitian yang digunakan terdiri dari observasi, mapping, analisis dan interpretasi data. Data yang diperoleh dalam penelitian di lapangan adalah nilai cacah radiasi permenit (Cpm), temperatur tanah, elevasi dan data lintang bujur, data-data ini yang kemudian digunakan untuk membuat peta. Hasil penelitian diperoleh bahwa distribusi kandungan radioisotop di lokasi berkisar dari 11 cpm - 22 cpm dan temperatur berkisar dari 22oC - 31oC. Keseluruhan area penelitian memiliki kadar radiasi yang rendah. Kontaminasi radioisotop pada lingkungan masih tergolong rendah dan secara umum cacah radiasi dan temperatur masih berada pada batas toleransi.
ABSTRACT
[Title: Distribution Mapping Of Radioisotop Content In Wooden Sweet Plant Areas In Nuabosi Ende Flores] Research has been carried out in the cassava plantation area of ​​Ndetundora III Nuabosi Village, Ende Sub-district, Ende Regency about the distribution mapping of radioisotope content. The purposes of this study are; first, to determine the interval of radiation counts and temperatures in the plantation area: Second, to map the distribution of radioisotope content in the plantation area based on radiation counts and temperature; Third, to estimate the area with a high radioisotope count. The research method that used in this study consists of observation, mapping, analysis and interpretation of data. Data obtained in the field of research are the value of radiation counts per minute (Cpm), soil temperature, elevation and latitude longitude data, these data are then used to make maps. The results showed that the distribution of radioisotope content in the research sites based on radiation counts, ranged from 11 cpm - 22 cpm and temperatures ranged from 22oC - 31oC. The entire research area has low radiation levels. Radioisotope contamination in the environment is still classified as low contamination and generally the radiation count and temperature are still at the tolerance limit.
KARAKTERISASI SIFAT FISIK DAN KIMIA SERTA GAMBARAN AIR TANAH PADA SUMUR-SUMUR DI SEPANJANG KELURAHAN MERDEKA KECAMATAN KUPANG TIMUR KABUPATEN KUPANG
Authors: Tameno Dolin Marlince , Wahid Abdul , Johannes Albert Zicko 
Published: March 2021

ABSTRAK
Penelitian karakterisasi sifat fisik dan kimia serta gambaran air tanah pada sumur-sumur di sepanjang Kelurahan Merdeka Kecamatan Kupang Timur Kabupaten Kupang telah dilakukan. Penelitian ini bertujuan untuk menggambarkan dan mengetahui kelayakan air pada sumur-sumur berdasarkan nilai salinitas, kadar oksigen terlarut (DO), tingkat keasaman (pH), suhu dan konduktivitas air tanah. Pengambilan data menggunakan alat-alat portable dan diolah menggunakan surfer 13 dan arcgis 10. Hasil penelitian menunjukkan bahwa yang nilai dari masing-masing parameter bervariasi karena ada beberapa faktor lingkungan. Secara keseluruhan nilai-nilai tersebut sesuai dengan standar kelayakan air layak konsumsi.
Kata kunci : Salinitas, Kadar Oksigen Terlarut, Derajat Keasaman, Suhu, Konduktivitas

ABSTRACT
Research on the characterization of the physical and the chemical of groundwater in wells along Merdeka Village Kupang East District of Kupang Regency had been done.This research aims to describe and to know the feasible of water in the wells based on salinity, dissolved oxygen(DO), acidity(pH), temperature, and conductivity of groundwater. Data retrieval used portable tools and processed by surfer 13 and Arcgis 10. The result varies because there are several environmental factor. Overall these values are suitable in the standard of feasible water consumption.
Keyword : Salinity, Dissolved Oxygen Levels, Acidity, Temperature, Conductivity