bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 111: Colorectal Cancer Presentation and Survival Outcomes in Nigeria: A Prospective Multi-Centre Cohort Study of 543 Patients
Authors: Aderibigbe Adeniyi , Dare Anna , Knapp Gregory , Alatise Olusegan , Kingham T. Peter 
Published: July 2021

Abstract
Purpose: Prospective data on colorectal cancer (CRC) presentation and outcomes in Nigeria is limited, however emergency presentation with advanced disease is thought to be common. Using the African Research Group for Oncology's prospective, multisite database of CRC patients in Southwest Nigeria, we evaluated risk factors for emergency CRC presentation and effects on overall survival (OS).
Methods: Consecutive CRC patients presenting between 2013 and May 2020 to five referral sites were included. Demographic, socioeconomic and disease-related risk factors for emergency presentation were evaluated using univariate and multivariable logistic regression methods. We compared OS between emergency and elective patients, stratified for clinical stage, using Kaplan-Meier survival and Cox proportional hazards methods.
Results: Of 543 CRC patients, 168 (30.9%) presented emergently. Median age at diagnosis was 55 years, 53% were male, and 4.8% reported a family history of cancer. Patients presenting emergently were more likely to have cancers proximal to the splenic flexure (41.1% vs 24.6%, p&lt;0.001), stage IV disease (62.7% vs 43.4%, p&lt;0.001) use non-motorized transport (54.4% vs 37.7%, p=0.001), have a lower median household income (USD$65/month vs $USD79/month, p&lt;0.04), and lower education level than those presenting electively. On multivariable regression analysis, only low BMI, stage IV disease, mode of transport and hospital site were significantly associated with emergency presentation. Median OS was 5.4 months (IQR 0.9-14.5; n=146) in the emergency group compared to 10.7 months (IQR 3/8-22.5; n=375) among elective patients. After adjustment for clinical stage at diagnosis, emergency presentation was still associated with significantly worse OS (HR 1.52; 95% C.I. 1.36-1.63, p&lt;0.001).
Conclusion: A high proportion of CRC patients in Nigeria present emergently, with advanced disease. Even after adjusting for clinical stage, these patients have worse overall survival. Earlier detection of cancers, including removing barriers to timely presentation and diagnosis, should be a focus of cancer control efforts.
Citation Format: Adeniyi Aderibigbe, Anna Dare, Gregory Knapp, Olusegan Alatise, T. Peter Kingham. Colorectal Cancer Presentation and Survival Outcomes in Nigeria: A Prospective Multi-Centre Cohort Study of 543 Patients [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 111.
Abstract 112: Use of WhatsApp to Improve Medical Provider Communication for Children with Wilms Tumor in Tanzania
Authors: Igenge John , Stocks Jacob , Zhang Gloria , George Mocha , Kiwara Frank , Mafwimbo Judy , Maxmilian Mastidia , Wesevich Austin , Schroeder Kristin 
Published: July 2021

Abstract
Purpose: Due to the rapid expansion of mobile phone usage throughout the world, mobile health (mHealth) technologies offer an innovative strategy to overcome challenges of care coordination and limited communication between pediatric cancer providers in LMICs. Our objective was to evaluate the use of the social media application WhatsApp to improve provider communication and outcomes for children diagnosed with Wilms tumor at a regional cancer treatment facility in Tanzania.
Methods: A WhatsApp provider group was established in 2016 to facilitate communication between surgical, medical and psychosocial support providers at the regional cancer referral hospital in northern Tanzania. All messages exchanged from 2016-2019 were extracted and coded for thematic content. Treatment compliance and process outcomes were compared for patients discussed versus those that were not over the 4-year period.
Results: A total of 669 messages for 55 patients were reviewed. Most messages were sent by the pediatric oncologist (44.8%, n=273) and urology resident (43.2%, n=263). Using the application to coordinate patient care reduced time to surgery from 90 days [IQR 65-109] to 60 days [IQR 47-80], and time to post-operative chemotherapy initiation from 46 days [IQR 39-55] to 19 days [IQR 16-30]. Rate of treatment abandonment was decreased for patients discussed in the chat group (26.7%) compared to those not discussed (38.2%).
Conclusion: To our knowledge this is the first study to assess the use of WhatsApp to improve provider communication for children with cancer in LMICs. As access to smartphone technology and internet access improves, applications like WhatsApp can be used as a low-cost strategy to target health system inefficiencies and improve outcomes for children with cancer globally.
Citation Format: John Igenge, Jacob Stocks, Gloria Zhang, Mocha George, Frank Kiwara, Judy Mafwimbo, Mastidia Maxmilian, Austin Wesevich, Kristin Schroeder. Use of WhatsApp to Improve Medical Provider Communication for Children with Wilms Tumor in Tanzania [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 112.
Abstract 22: Screening and Treatment of Female Sex Workers for Cervical Precancers in Cameroon
Authors: Manga Simon , Nulah Kathleen , Manjuh Florence , Fokom Joel , Ngatchou Denisse , Welty Edith , Shete Sanjay , Liang Margaret , Welty Thomas 
Published: July 2021

Abstract
Purpose: To prevent cervical cancer among female sex workers (FSWs) who are at high risk of acquiring HPV infections (through occupational exposure) that may progress to invasive cervical cancer (ICC) if not treated.
Methods: With funding from a Prevent Cancer Foundation grant and in collaboration with Horizons Femmes, an NGO that provides services to FSWs, the Women's Health Program (WHP) of the Cameroon Baptist Convention Health Services screened FSWs in three large Cameroonian cities with visual inspection with acetic acid and Lugol's iodine (VIA/VILI) enhanced by digital cervicography (DC) and collected vaginal specimens from FSWs aged 30+ years for AmpFire HPV genotyping.
Results: Of the 757 FSWs who were screened in August 2020, 510 (67.4%) were aged 30 or over, 308 (60.4%) had one or more high risk HPV types and 47(9.2%) had positive VIA/VILI-DC (34 with ablative eligible lesions and 13 with LEEP eligible lesions). Of the women less than age 30, 27(10.9%) had positive VIA/VILI-DC (92.6% with ablative and 7.4% LEEP eligible lesions). Of the 74 women with ablative and LEEP eligible lesions, 38 (64.4%) and 8 (53.3%) respectively were treated. Of 272 women aged 30+years who were HPV positive but DC negative, 61 (22.4%) were treated with thermal ablation. The WHP continues to follow up on FSWs who need treatment and is analyzing HPV genotypes' frequency and their relation to the VIA/VILI-DC results.
Conclusions: With appropriate education and support, FSWs can be screened for cervical cancer and a high proportion of those with positive screening tests can be appropriately treated to reduce their risk of ICC.
Citation Format: Simon Manga, Kathleen Nulah, Florence Manjuh, Joel Fokom, Denisse Ngatchou, Edith Welty, Sanjay Shete, Margaret Liang, Thomas Welty. Screening and Treatment of Female Sex Workers for Cervical Precancers in Cameroon [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 22.
Abstract 25: End User Support for Telemedicine Oncology Care in Sub Saharan Africa
Authors: Sigu Lamech , Achieng Emmah , Asirwa Chite , Kitur Gloria 
Published: July 2021

Abstract
Purpose: Health Information Technology has hugely improved patient healthcare with fast and simple information access and communication. Telemedicine uses telecommunications technology as a tool to deliver health care to populations with limited access to care. International Cancer Institute (ICI) number one goal is to provide end-to-end solutions for optimization of care on patients' journey in sub-Saharan Africa. Supporting the end-user clearly shows there is a lot going on “under the skin” in healthcare Information technology (IT) to bring information access to life and patients closer to the oncology experts. Methods: In 2020, ICI IT team provided end-user support in bi-weekly multidisciplinary oncology –tumour boards with specialists from Africa and the world. It also provided support in Provider-to-provider tele-consults for patients in 10 partner counties in Kenya. The IT team also provided online support to healthcare providers to access online oncology preceptorships/training and webinars in different aspects of the cancer control continuum.
Result: The IT team was able to support over 80 Multidisciplinary tumor boards, ensuring a team-based care approach to delivering care. Provider-to-provider tele-oncology ensured a platform to support interprofessional care and mentorship to non-specialists in remote sites. It has also provided one on one county patient consultations and hence ensured delivery of cancer services in 10 county government clinics & 8 private health facilities. Over 300 patient consults have been completed. Online platforms have ensured healthcare provider training despite COVID 19 restrictions; ICI has successfully trained over 1000 health care providers using eLearning and online platforms.
Conclusion IT support has successfully provided assistance to physicians, healthcare providers, and patients with technical & non-technical support demonstrating the potential of delivering specialized oncology consultations and improved access to information in primary care settings with limited resources.
Citation Format: Lamech Sigu, Emmah Achieng, Chite Asirwa, Gloria Kitur. End User Support for Telemedicine Oncology Care in Sub Saharan Africa [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 25.
Abstract 29: Demographics, Source of Health Information, and Screening-Related Factors on Interests in Cancer Communication Programs among Church-Based Chinese Adults
Authors: Hou Su-I 
Published: July 2021

Abstract
Purpose: This study examined demographics, source of health information, and screening-related factors on interests in cancer screening communication programs among church-based Chinese adults. In particular, interest in social-media delivered cancer communication programs was analyzed.
Methods: Participants were recruited from 9 Chinese churches. A self-administered survey including items on screening knowledge and beliefs, and sources of health information and preferred delivery strategies was administered. Interests in cancer prevention communication programs were recoded into no (little or medium interests) and yes (high or very high interests).
Results: 372 Chinese participated in the survey, mean age was 44.31 (SD=14.74), 60% males, and the majority had college education (85%). Overall, about 46%-52% got health information from the Internet or social media sites, with internet being the top source of health information (mean=3.46 on 5-point Likert scale). Half showed high interests in social-media cancer communication programs if available. After adjusting for age, gender, marital, and family cancer history, logistic regressions showed those who were single (OR=2.18; p=.021), perceived higher cancer risk (OR=1.47; p=.022), had been a primary cancer caregiver (OR=2.23; p=.026), and had lower screening barriers (OR=.823; p&lt;.001) were more likely to report interests in cancer communication programs (p&lt;.001; 71% correct classification). Analyses further showed that those interested in programs delivered via social media had higher acceptance towards academic social media sites (OR=1.98; p=.002) and believe social media as an effective strategy for health communication (OR=2.41; p=.001).
Conclusions: Current data show beliefs towards social media was the only factor related to interested in program delivered via social media channel; while cancer related factors (higher perceived cancer risk, lower perceived barriers, and cancer caregiver experience) were key to interests in cancer communication programs. Study results has implication on program delivery strategies and identifying potential early adopters for cancer communication programs among Chinese adults.
Citation Format: Su-I Hou. Demographics, Source of Health Information, and Screening-Related Factors on Interests in Cancer Communication Programs among Church-Based Chinese Adults [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 29.
Abstract 33: Characterizing the Changes in Mechanical Properties of the Actin Cortex in Highly Metastatic Cancers
Authors: Neal Jamie , Smith Chynna , Baird Michelle , Cartagena-Rivera Alexander 
Published: July 2021

Abstract
Purpose: Cancer is the second leading cause of death globally with approximately 9.5 million cancer related deaths worldwide in 2018. Many of these deaths are the result of complications due to metastatic progression. Metastasis is a complex, dynamic process that requires cancerous cells to undergo major cytoskeletal reorganization prior to migration and intravasation. Previous research studying the biophysical properties of the cytoskeleton utilize techniques that require the cells be adhered to a hard substrate, causing modifications to the organization of the cytoskeleton that are not physiologically relevant. To better understand the mechanics of cancer cells and metastasis, we have developed an alternative approach to studying the cell cortex.
Methods: Utilizing a novel, Atomic Force Microscopy-based, quasi-static force spectroscopy method pioneered by our lab, we are able to measure cortical tension and intracellular pressure by gently compressing non-adherent cells with a tipless cantilever, which results in a more physiologically relevant cortical morphology. We utilized this method to compare changes in cortical mechanics between healthy and cancerous cells, as well during metastatic progression of cancer cells in vitro for melanoma, breast, and ovarian cancers.
Results: Previous research that utilized adherent cells indicated a decrease in stiffness after tumorigenesis, but our method indicates an increase in stiffness by determining the cortical tension and intracellular pressure in the case of melanoma. Additionally, a non-linear, overall decrease in tension and pressure can be seen in both the melanoma and ovarian cell lines that model increasing metastatic potential.
Conclusion: Due to the important role invasiveness plays in the severity of cancer, categorizing the mechanical properties of cancer cells may prove to be a critical diagnostic and prognostic indicator for oncologists. Our novel force microscopy method better captures physiologically relevant cortical morphology and may enable the capture of clinically significant information on tumor invasiveness and progression.
Citation Format: Jamie Neal, Chynna Smith, Michelle Baird, Alexander Cartagena-Rivera. Characterizing the Changes in Mechanical Properties of the Actin Cortex in Highly Metastatic Cancers [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 33.
Abstract 5: Establishment of ASCP Equipment Donation Program to Support International Histopathology Laboratories
Authors: Basu Debby , Tashpulatova Lola , Milner Dan , Landgraf Kenneth 
Published: July 2021

Abstract
Purpose: In order to address the unmet needs of international histopathology laboratories with regard to procurement of laboratory equipment and consumables, the ASCP Center for Global Health has established a program which facilitates donation of these goods to laboratories in need.
Methods: Using a member-based outreach approach, donors with key histopathology laboratory equipment or consumables submit an interest in donation to ASCP. ASCP performs an assessment of the quality and longevity of the donated item. ASCP pairs the donation with a laboratory within the Partners for Cancer Diagnosis and Treatment Initiative network which has expressed need. Recipient lab-specific parameters are further evaluated (e.g. space, voltage compatibility, need for service contract, etc.). Should the donation be a compatible fit, ASCP works with both recipient and international shippers to facilitate the donation.
Results: Since August 2018, ASCP has supported nearly 20 international equipment donations (fair market value of goods totaling approximately $120K) to 12 countries. These donations are composed of routine histopathology lab consumables (e.g. tissue cassettes, glass slides, etc.) as well as specialized equipment (e.g. whole slide imaging scanners, microtomes, microscopes, etc.), basic laboratory operations equipment (e.g. computers, keyboards, etc), and educational materials (e.g. textbooks, etc.).
Conclusions: This donation program allows for redistribution of key histopathology lab equipment and consumables to laboratories in needs. The impact of this program has been far-reaching, both relieving laboratory strain associated with under-procurement often experienced in international laboratories to expanding capacitation of diagnostic testing services including, in some cases, telepathology-based secondary consultations from subspecialty pathologists unavailable in-country.
Citation Format: Debby Basu, Lola Tashpulatova, Dan Milner, Kenneth Landgraf. Establishment of ASCP Equipment Donation Program to Support International Histopathology Laboratories [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 5.
Abstract 56: Landscape and Challenges of Cancer Registration in the Middle East, North Africa and Turkey (MENAT)
Authors: Sater Zahi Abdul , Shamseddine Ali , Taher Ali , Fouad Fouad , Abu-Sitta Ghassan , Fadhil Ibtihal , Saab Raya , Sullivan Richard , Adib Salim M. , Saleh Shadi , Mukherji Deborah 
Published: July 2021

Abstract
Purpose: National and regional cancer control strategies have been identified as essential tools for reducing and managing the growing burden of cancer in low- and middle-income countries. Cancer registration is an instrumental component of any national cancer control strategy. In the Middle East, North-Africa and Turkey (MENAT) region, cancer registration varies immensely across countries and faces multifaceted challenges including protracted conflict. This study maps out the present capacities and outputs of cancer registration in the MENAT region and identifying thematic barriers facing implementation and utilization of cancer registry data.
Methods: We employed a mixed-method approach utilizing a self-administered online survey with open and close ended questions targeting national and institutional cancer registry managers in the MENAT countries. The questions focused on the country-wide and registry-specific status and challenges of cancer registration.
Results: Data from 20 MENAT countries were collected through the online survey. MENAT registry managers reported the presence of 97 population-based registries, 48 hospital-based registries, and 24 pathology-based registries. Most population-based registries were well or partially developed. Lack of accurate death records, complete medical records, communication between stakeholders, and trained personnel were critical challenges. These challenges are more severe in conflict-affected countries (both active conflict zones and neighbouring regions affected by conflict). Cancer registration challenges in these countries included weak health care infrastructure, absence of legislation mandating cancer registration, and cessation or disruption of cancer registration due to active conflict and loss of funding. Furthermore, refugee host countries such as Lebanon, Turkey and Jordan, also reported conflict-related challenges including refugee mobility and lack of accurate data on forced migrants.
Conclusion: This study provides a much-needed understanding of the current landscape and contextual challenges affecting cancer registration in the MENAT, especially in conflict affected settings. These data are important for identifying areas on which to focus regional capacity-strengthening initiatives.
Citation Format: Zahi Abdul Sater, Ali Shamseddine, Ali Taher, Fouad Fouad, Ghassan Abu-Sitta, Ibtihal Fadhil, Raya Saab, Richard Sullivan, Salim M. Adib, Shadi Saleh, Deborah Mukherji. Landscape and Challenges of Cancer Registration in the Middle East, North Africa and Turkey (MENAT) [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 56.