bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased lipid peroxidation, depleted non‐enzymatic antioxidant, and variability in trace elements concentration in serum are correlated with Bangladeshi end‐stage renal disease population
Authors: Hossain Md. Shohel , Amin Mohammad Nurul , Das Abhijit , Khan A. K. M. Jahirul Hossain , Sohel Md , Ahmed Jamiuddin , Islam Md. Monirul , Hossain Md. Shahadat , Rahman Md. Masudur , Nesa Mst. Luthfun , Islam Mohammad Safiqul 
Published: August 2021

AbstractIntroductionEnd‐stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case‐control study was planned to determine the extent of serum lipid peroxidation, non‐enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls.MethodsDetermination of lipid peroxidation was carried out by ascertaining concentration of malondialdehyde (MDA) and vitamin C in serum using UV spectrophotometry whereas atomic absorption spectroscopy was used for trace elements estimation. The statistical analysis was conducted via the independent t‐test samples and Pearson correlation test.ResultsThe blood serum study has shown substantially higher MDA values than the control level and lowers vitamin C levels in the patient population (P < .001). A negative correlation was found between the vitamin C in serum with BMI and MDA for both patients (r = −0.017 and r = −0.132, respectively) and the control group (r = −0.014 and r = −0.229, respectively) after Pearson's correlation analysis. Regarding trace elements, significantly (P < .001) lower concentrations of zinc, copper, and manganese were found in the patient group than control subjects. Inter‐element‐relationship established a strong positive harmonization between these studied elements in both the cases of patients and control subjects.ConclusionOur results indicate strong associations of the pathogenesis of ESRD with depleted non‐enzymatic antioxidant, increased lipid peroxidation, and inconsistency in trace elements concentration in serum, which may provide a prognostic tool for the treatment of this concerning the disease.
The effect of skeletal muscle‐derived cells implantation on stress urinary incontinence and functional urethral properties in female patients
Authors: Blaganje Mija , Lukanović Adolf 
Published: August 2021

AbstractObjectiveTo evaluate improvement of stress urinary incontinence (SUI) and functional status of the urethra after autologous skeletal‐muscle derived cell (aSMDC) implantation.MethodsPhase I–II, open, non‐randomized, single‐center study of ultrasound guided aSMDC implantation (dosed at 0.2 × 106 cells/2 mL) into the external urethral sphincter to treat SUI.ResultsA total of 38 patients were treated and followed for 2 years. SUI measured by Incontinence Episode Frequency score, short pad test, quality of life, patient's and clinician's perception significantly improved and remained improved after 2 years. However, urodynamic urethral properties in general did not improve at 1‐year after treatment. Subgroup analysis revealed that addition of an adjuvant functional electrical stimulation therapy discontinued 4 weeks after injection in the compliant group, gave better urodynamic values and maintained the long‐term SUI improvement at 2 years.ConclusionThe aSMDC injection was safe and well‐tolerated by patients. The status of SUI improved and with it the quality of life of patients, even if this was not necessarily reflected in the urodynamic urethral properties. Electrical stimulation, as an adjuvant therapy, could have an essential role in the success of the therapy.Clinical registrationClinical study was registered under Eudra‐CT number: 2010‐021867‐34 at European Clinical Trial Database (EudraCT), accessible at: EudraCT (europa.eu).
Knotted ureteral single‐J stent in a patient with ureterocutaneostomy
Authors: Koike Yuhei , Urabe Fumihiko , Iwatani Kosuke , Nukariya Yuto , Tanaka Masatoshi , Tashiro Kojiro , Kimura Takahiro , Tsuzuki Shunsuke , Egawa Shin 
Published: August 2021

IntroductionAlthough ureteral stent catheterization is a common procedure in urological practice, knotting of a ureteral catheter is a very rare complication.Case presentationA 62‐year‐old man underwent cystectomy and ureterocutaneostomy for bladder cancer. The ureteral single‐J stent was changed every month postoperatively without complications. However, at postoperative 30 months, resistance was experienced while adjusting the stent position after the exchange. Abdominal radiography revealed knotting of the stent at the right renal pelvis. The knotted stent was percutaneously removed because the patient had only one functioning kidney. A nephrostomy tract was established and the ureteral stent was exchanged. No complications occurred in the perioperative period.ConclusionWe encountered a case of a knotted ureteral single‐J stent in a man treated with ureterocutaneostomy. In this case, resistance was noticed during extraction; the possibility of stent knotting should always be considered, and an appropriate removal strategy must be planned.
Immune‐related dermatitis during combined treatment with pembrolizumab and axitinib in a patient with metastatic renal cell\x92carcinoma with stasis dermatitis
Authors: Imai Shunsuke , Nakamura Masaki , Chujo Satomi , Ooki Ryousuke , Inoue Yasushi , Horiuchi Hajime , Morikawa Teppei , Uchino Keita , Igarashi Atsuyuki , Shiga Yoshiyuki 
Published: August 2021

IntroductionThe combination of pembrolizumab and axitinib has recently been approved as a first‐line treatment for previously untreated metastatic renal cell carcinoma. However, immune‐related adverse events are not well known.Case presentationA 65‐year‐old male was diagnosed with renal cell carcinoma with metastases to the brain and lungs. The patient had a medical history of stasis dermatitis. During the combined treatment of pembrolizumab and axitinib, blisters appeared on the lower extremities. Skin biopsy revealed septal panniculitis, pustules, and perivascular lymphocytic and neutrophilic infiltration of the skin, and the patient was diagnosed with immune‐related dermatitis. The dermatitis improved with oral prednisolone treatment.ConclusionA case of immune‐related dermatitis during combinatorial treatment with pembrolizumab and axitinib for renal cell carcinoma has been reported. Preexisting stasis dermatitis may have affected the onset and deterioration of immune‐related dermatitis.
Systems and Software Interface Survey
Authors: Muscarella Sally , Osaisai Macaulay , Sheard Sarah 
Published: August 2021

ABSTRACTINCOSE formed the Systems and Software Interface Working Group (SaSIWG) in 2017, responding to the Corporate Advisory Board interest in software and problems identified in the systems and software interface (physical, logical, data, and human). This third SaSIWG paper presents a systems engineers, software engineers, and project managers survey discussing best practices and the priority challenges related to the interface between systems and software. We group and summarize the best practices mentioned by the 31 interviewees then address priority challenges and problems. Systems engineering done well includes an ever‐increasing amount of Model‐Based Systems Engineering. It also includes developing and holding to a vision, managing data, ensuring inter‐disciplinary work, planning systematic verification, and ensuring modularity. Systems engineering must evolve to meet new challenges and, most importantly, systems engineer expertise must include software engineering.
“Book Club” Guides A Working Group to Create INCOSE System‐Software Interface Products
Authors: Sheard Sarah , Bouyaud Mickael , Osaisai Macaulay , Siviy Jeannine , Nidiffer Ken 
Published: August 2021

ABSTRACTMany software‐dominant organizations ignore systems engineering completely. A recent popular book described one such organization in a fable format. The INCOSE Systems and Software Interface Working Group chose to read this book as a weekly professional development seminar to investigate where systems engineering should fit in software‐dominant organizations of the type that do not currently involve INCOSE's systems engineers. This seminar culminated in an “author day,” where the book's author responded to our questions and discussed our potential role. The book club activities produced several drafts we can turn into products to help INCOSE systems engineers better understand software, and systems engineers' potential role in such organizations, to help improve software‐intensive system success.
Systems Engineering and DevSecOps: Reviewing the Principles
Authors: Turner Richard 
Published: August 2021

ABSTRACTAs software engineering adopts a more continuous delivery mode for embedded and complex systems, systems engineering must adapt and influence DevSecOps and related practices. In this article, I revisit agile, lean, and DevSecOps principles and comment on their interactions, focusing on those that may increase product and system development, deployment, and evolution risk, and those that increase improvement opportunities through productive engagement across the two disciplines. This material is also available as a Software Engineering Institute Blog Post from 15 March 2021 [https://insights.sei.cmu.edu/blog/comparing-devsec-ops-and-systems-engineering-principles/.]
Common Discourse: Reflections on Pandemic Literacy Teaching
Authors: Hillyer Jowen , Stolp Sue , York Melissa 
Published: August 2021

AbstractIn this forum, three educators spanning elementary and secondary contexts reflect on their experiences as they respond to the following question: How has the pandemic impacted issues of access in your teaching practice, and what are some implications for teaching in the post‐pandemic return to physical spaces of literacy learning? Across their accounts, the authors describe how their experiences have re(shaped) their perspectives about students and learning as well as prompted questions about the digitalization of pedagogy and the creation of inclusive, equitable learning spaces for all learners.
Virtual care revolution: Impact on clinical pharmacy practices in the Department of Veterans Affairs
Authors: Ourth Heather L. , Heyworth Leonie , Galpin Kevin , Morreale Anthony P. 
Published: August 2021

AbstractFor nearly two decades, the Department of Veterans Affairs (VA) has invested in the development and implementation of telehealth services which comprises video, store and forward services, and remote patient monitoring. Virtual care includes telehealth services along with telephone care and e‐consults. These efforts proved critical in 2020 due to the coronavirus disease 2019 (COVID‐19) pandemic. Expanding implementation of telehealth to the home became an access and safety imperative. This article highlights VA efforts and infrastructure for expansion of telehealth into the home and clinical pharmacy practice integration of virtual care. The acceptance of technology coupled with advancements in legislation, policy, and technologies has resulted in expanded applications within the health care system. While continued expansion of virtual care seems inevitable, there remain challenges to ensuring both access to virtual care and the safety and effectiveness of the care delivered. Looking to the future, there will be a continued need for future research on outcomes associated with virtual care, exploration of the benefits of video capability over telephone care, and cost‐effectiveness.
Describing the delivery of clinical pharmacy services via telehealth: A systematic review
Authors: Melton Tyler , Jasmin Hilary , Johnson Haden F. , Coley Annika , Duffey Sawyer , Renfro Chelsea P. 
Published: August 2021

AbstractIntroductionTelehealth offers a promising opportunity for the delivery of clinical pharmacy services by increasing the accessibility of health care, extending the reach of clinical services, and allowing pharmacists to engage with patients who might otherwise be overlooked. The objectives of the project were to discover effective strategies for the delivery of clinical pharmacy services via telehealth and to identify core components of comprehensive medication management (CMM) that are deliverable via telehealth.MethodsA systematic literature review was performed by searching four databases (Cumulative Index to Nursing and Allied Health Literature [CINAHL], PubMed, Scopus, and Web of Science) for relevant citations using keywords and subject headings relating to telemedicine, clinical pharmacy services, and health conditions. Studies were eligible for inclusion in the review if the interventions they describe involved telehealth technologies and pharmacist care. Blind screening of abstracts and full‐text review was completed by six researchers divided into teams of two. Any discrepancies were resolved by the corresponding author.ResultsFifty‐nine studies met the inclusion criteria, most (n = 53) of which were conducted in the U.S. Five studies (8.5%) reported pharmacist training as an implementation strategy. The telehealth technologies most regularly utilized were telephone‐based interventions (n = 45), videoconferences (n = 13), and web‐based (n = 4) interventions, with five studies using a combination of technologies. Most studies focused on hypertension (n = 22), diabetes (n = 20), or lipid‐related (n = 14) disease state management. Eighteen studies qualified as CMM (n = 18), with most involving all five essential CMM functions.ConclusionThis systematic review study highlights opportunities for pharmacists to deliver clinical pharmacy services using telehealth. The majority of clinical pharmacy services described in the accessed literature was provided via telephone and focused on targeted monitoring of disease states. While studies reporting the use of CMM interventions were limited, there is an opportunity to increase the application of CMM principles as healthcare systems transition to providing more telehealth services.
Phone a pharmacist: Telepharmacy services at freestanding emergency departments
Authors: Campbell Matthew J. , Tietz David , Sayles Stephen , Hustey Frederic , Phelan Michael P. 
Published: August 2021

AbstractIntroductionEmergency medicine (EM) pharmacy practice has experienced significant growth in the past decade, but the scope of services provided for freestanding emergency departments (FSEDs) has not been previously described.ObjectivesThe primary objective was to describe EM pharmacist interventions provided through telepharmacy services for three FSEDs.MethodsThis was a retrospective chart review conducted in three FSEDs that are part of a large health system. EM pharmacists provide remote clinical coverage for the FSEDs. Pharmacist interventions for FSED patients between 1 January 2017 and 31 December 2018 were eligible for inclusion. Documentation related to non‐direct patient care activities was excluded. Drug therapy recommendations were categorized by therapeutic drug class and the proportion associated with Institute for Safe Medication Practices (ISMP) high‐alert medications was analyzed. The clinical significance of a random sample of drug therapy recommendations was rated using a validated scale. Data was analyzed descriptively and a weighted Kappa statistic was calculated to assess inter‐rater reliability.ResultsA total of 4313 interventions met inclusion criteria with drug therapy recommendations accounting for 38.4% of all interventions. Of 1664 drug therapy recommendations, there were 1424 linked to a medication with the most frequently implicated therapeutic classes being antimicrobial agents (n = 732; 51.4%), vaccines (n = 168; 11.8%), and cardiovascular agents (n = 90; 6.3%). ISMP high‐alert medications accounted for 11% (n = 157) of these recommendations with antithrombotic agents (n = 51; 32.5%), insulin (n = 34; 21.7%), and opioids (n = 20; 12.7%) most frequently implicated. In a random sample of drug therapy recommendations, 19.2% were rated as significant errors by both reviewers with moderate inter‐rater reliability (κ = 0.55; SE 0.09). When assessing the value of service, 59% of interventions were rated as significant by both reviewers with fair inter‐rater reliability (κ = 0.22; SE 0.05).ConclusionEM pharmacists provided clinically significant drug therapy recommendations through telepharmacy services which may represent a novel approach to optimize patient care in FSEDs.
Clinical pharmacy specialists providing consistent comprehensive medication management with increased efficiency through telemedicine during the COVID19 pandemic
Authors: Thomas Ashley M. , Baker Jennifer W. , Hoffmann Terry J. , Lamb Kristen 
Published: August 2021

AbstractIntroductionThe Veterans Affairs (VA) has been at the forefront of harnessing the skills of clinical pharmacy specialists (CPS) in patient‐aligned care teams (PACT) to improve patient care outcomes and create access for veterans. With the unfortunate arrival of Coronavirus disease 2019 (COVID19), PACT CPS were duty‐bound to expand telehealth services at an accelerated rate. The purpose of this quality improvement analysis is to compare CPS efficiency as well as some objective patient metrics to assess for a change in the quality of care. This is the first study to compare the efficiency and quality of care by CPS in the VA pre‐COVID19 and during the COVID19 pandemic.MethodsThis is a retrospective review of PACT CPS comprehensive medication management from 3/10/19 to 11/30/19 and 3/10/20 to 11/30/20. Data points focused on clinic encounters, patient accountability to appointments, disease state expansion, and markers of disease‐state management. Given diabetes and hypertension are the main disease states managed by most PACT CPS', the study evaluated changes in hemoglobin A1c (HbA1c) and blood pressure (BP) between the two cohorts as well. Data were analyzed using GraphPad Software or Microsoft Excel. A student T‐test was used for continuous data and Chi‐squared or Fishers Exact for nominal data.ResultsThe total number of PACT CPS encounters increased 32% in 2020, and the number of unique patients increased by 12%. There were a statistically significant increase in telephone and direct‐to‐consumer (DCT) video visits. The rates of no shows and cancellations significantly decreased between 2019 and 2020. There was no difference in the average change in HbA1c or average blood pressure between the two study groups.ConclusionsWhen PACT CPS services transitioned from primarily face‐to‐face visits to all virtual care, the consistency of care improved, and the quality of care was not compromised.
Review of telehealth interventions for childhood obesity in minority, low‐income or underserved populations: Opportunity for pharmacists
Authors: Barefield Kimberly L. , Rollins Brent 
Published: August 2021

AbstractThere has been a steady increase in childhood obesity, comparable to that seen in adults, over the past decade with the incidence almost tripling. As seen in adults, there are trends in discrepancy among gender, ethnicity, race, and underserved populations in the incidence of childhood obesity. Effective interventions for childhood obesity need to be broad including both diet and exercise, but there is little evidence on the most effective approach. The use of telehealth interventions to treat childhood obesity in ethnic, low‐income, and underserved populations could be an effective platform. The pharmacist is a health care professional that is easily accessible to these populations and can assist with lifestyle modification counseling for weight loss. The purpose of this review is to summarize and evaluate the effectiveness of telehealth modalities on weight loss in overweight/obese children identified as minority, low‐income, or underserved populations. The review found there were many different forms of telehealth interventions utilized which may have influenced the success of evaluated outcomes. The majority of modalities did not improve BMI or BMI z‐score when not accompanied by a form of real‐time intervention. Studies, where telehealth was accompanied by motivational coaching, did show a significant decrease in BMI and/or BMI z‐score.
Therapeutic plasma exchange in patients with severe obesity (BMI >40): A survey of practices in the United States
Authors: Babariya Shraddha Patel , Vivero Angelica , Peedin Alexis , Karp Julie Katz 
Published: August 2021

AbstractBackgroundThe prevalence of obesity in the United States is estimated at 42.4% and expected to increase over the next decade. Therefore, understanding how to best perform certain medical procedures on severely obese (SO) patients is a necessity. This study presents results on the current methods of performing therapeutic plasma exchange (TPE) on SO patients. This paper aims to contribute to the existing literature by providing new insights into calculating plasma volume (PV) for TPE in SO patients.MethodsBlood Bank/Apheresis Directors at all institutions with pathology residency and/or blood banking/transfusion medicine fellowship programs were asked to complete a 5‐question online survey about their institutional policies regarding TPE in SO patients. Survey data were analyzed to determine if institutions have policies in place to calculate PV in SO patients.ResultsOut of the 144 institutions contacted, 45 (31%) completed the survey. Nine (20%) institutions had a policy to calculate PV differently for SO patients, 7 (16%) reported a specific body mass index (BMI) above which they alter PV calculation, and 7 (16%) reported a maximum volume exchanged in SO patients.ConclusionA minority of responding institutions had specific policies in place to calculate PV for TPE in SO patients. Practice patterns for calculating PV for TPE in SO patients varied, with some institutions adjusting PV calculations and others setting a maximum volume to be exchanged regardless of BMI. These findings highlight the need for establishing a clear method of calculating PV in SO patients.
Synthesis of nanorods assembled V‐doped WO3 microspheres and the catalytic performance in thermal decomposition of ammonium perchlorate
Authors: Li Xiongjian , Hu Hao , Chen Piao , Yang Shuijin 
Published: August 2021

AbstractV‐doped WO3 microspheres composed of nanorods radially grown from the center were fabricated via a simple hydrothermal method. The as‐obtained products were characterized by several techniques such as X‐ray powder diffraction (XRD), energy dispersive spectrometer (EDS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Raman spectrum, and Brunauer–Emmett–Teller (BET). It was found that V atoms were incorporated inside the hexagonal WO3 lattice. On the basis of time‐dependent experiments, the formation mechanism for the as‐prepared V‐doped WO3 micro‐nanostructures was discussed. In addition, the catalytic properties of the synthesized material on the thermal decomposition of ammonium perchlorate (AP) were evaluated by thermal gravimetric and differential thermal analysis (TG/DTA), which showed the thermal decomposition temperatures of AP in the presence of 1, 2, and 4 wt% of V‐doped WO3 micro‐nanostructures were reduced to 399, 393, and 380°C, respectively.
Clinical presentation and natural history of Barth Syndrome: An overview
Authors: Taylor Carolyn , Rao Emily S. , Pierre Germaine , Chronopoulou Estathia , Hornby Brittany , Heyman Andrea , Vernon Hilary J. 
Published: August 2021

AbstractBarth Syndrome is a rare X‐linked disorder caused by pathogenic variants in the gene TAFAZZIN, which encodes for an enzyme involved in the remodeling of cardiolipin, a phospholipid primarily localized to the inner mitochondrial membrane. Barth Syndrome is characterized by cardiomyopathy, skeletal myopathy, neutropenia, and growth abnormalities, among other features. In this review, we will discuss the clinical presentation and natural history of Barth Syndrome, review key features of this disease, and introduce less common clinical associations. Recognition and understanding of the natural history of Barth Syndrome are important for ongoing patient management and developing endpoints for the demonstration of efficacy of new and emerging therapies.