bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variates and Manipulative Skills on Computer Operations of High School Students of the University of Eastern Philippines System
Authors: Galit – Cabe Honey Rose 
Published: March 2021

This study aimed at examining the varieties and manipulative skills in computer operations of fourth year high school students of the University of Eastern Philippines System. A self-structured closed questionnaire with 5-point Likert scale was designed for data collection from a sample of 80 high school students and 6 teachers. This study employed the descriptive –correlational survey type of research design, Statistical tools such as frequency counts, percentages, mean, ranking and multiple regression were used to interpret and analyze the data.
Findings revealed that the students were more skilled in terms with their manipulative skills in computer operations, more favorable attitudes while working in computer operation, and a very good academic performance showed in English, Mathematics, and Computer subjects.
Adult Intussusception in a Referral Hospital in Sub-Saharan Africa: Case Report and Literature Review
Authors: Wismayer Richard 
Published: March 2021

Introduction: Adult intussusception is a rare form of bowel obstruction which constitutes less than 5% of all cases of intussusception. In Sub-Saharan Africa, adult intussusception is not a rare cause of bowel obstruction. It is usually caused by a lead point which may be malignant in up to 50% of cases unlike childhood intussusceptions which are usually idiopathic. The author reports on a case of intussusception followed by a literature review on the pathogenesis and treatment options for intussusception in Sub-Saharan Africa.
Presentation of Case: A 46 year old gentleman presented with nonspecific abdominal symptoms mainly with epigastric pain associated with vomiting. No palpable masses were felt in the abdomen. Laboratory investigations were unremarkable. At laparotomy an ileo-ileal-caecal intussusception was found and when reduced 30 cm of ileum resulted gangrenous. A limited resection of the small bowel with end-to-side anastomosis involving the viable ileum and ascending colon was carried out. A lobulated lipoma was the pathological lead point on inspection of the ileum in the resected specimen.
Discussion: The atypical clinical features and pathogenesis of adult intussusception are described in the case presented. In addition, this study reviews the literature regarding the pathogensis, clinical features, diagnostic imaging modalities and treatment options of adult intussusception.
Conclusions: Patients with long standing abdominal pain and vomiting should have an abdominal CT scan to achieve a clear diagnosis of intussusception. This will avoid any unnecessary delays in the operative management of this condition.
The Influential Incidence and Prevalence of Angiohemophilia
Authors: Sultan Khalid Satam , Khaleel Asmaa Mohammed , Abdullah Salih Khudhair 
Published: March 2021

Background: Angiohemophilia (VWD) is a common human inherited disease where the parent carrying the gene may or may not be symptomatic. VWD is an illness of the blood that does not coagulate correctly. Blood contains numerous proteins to stop the bleeding of the body. Von Willebrand factor VWF is one of these proteins.
Aim: Current study was planned to classify the prevalence of VWD between 2014 and 2019 in Nineveh province.
Materials and Methods: The study included 829 patients, 365 of which were carriers of one or more hemophilia factors deficiency. Special Staco kit was used for detecting VWF.
Results: Thirty out of 365 patients were diagnosed with VWD. The association between VWD and other associated variables is not significant. An acceptable value was found between age and blood type.
Conclusion: The origins of families that hold the disease mutant gene must be tracked, births taken and infection mitigation techniques used in these families established. Do not neglect the value of the sort of blood that affects the VWD directly.
Increasing Singulation Machine UPH through Characterization and Standardization of Saw and Handler Parameters through DMAIC Methodology
Authors: Rolluqui Lloyd L. , Cabading Jr Patricio A. , Domingo Jimmy P. 
Published: March 2021

This study aims to address the problem of machine saturation and low capacity at package singulation, caused by increasing product loading and new devices that requires frequent machine setups and conversions.
With this evaluation, the process and equipment engineering group collaborated to improve the machine unit per hour (UPH) of package singulation machines at the manufacturing assembly. Target improvements were divided into three phases, so that the team could focus more on each phase and was able to define robust parameters without compromising the product quality. DMAIC methodology was used to improve the productivity of package singulation machines. With the help of our methodology, we identified the root cause and contributing factors to the problem.
UPH improvements per machine were validated and assessed in terms of machine efficiency and product quality, because of characterization and standardization of every parameter in each phase of the project. The achieved total improvement was of 17.64%.
Research on Meeting the Demand of the Population for a Group of Medicines Intended for the Treatment of Skin Diseases
Authors: Radzhabova Maryam  Magomedeminovna , Elgakaeva Madina Aptievna , Kostikov Andrey Petrovich , Kabanova Tatiana Alekseevna , Goncharov Vitaly V. , Subbotin Ivan Gennadievich 
Published: March 2021

The problem of the spread of skin diseases in Russia and abroad in the last period is quite acute. Among the reasons for the development of this group of diseases, researchers determine genetic factors, poor ecology, impaired liver function, etc. In this regard, those suffering from this group of diseases are necessarily provided with qualified medical care, and pharmacy institutions form the necessary range of drugs that can improve the standard of living of patients. For this reason, we consider it necessary to analyze the level of demand for certain drugs used for the treatment of skin diseases in the pharmacy network of Belgorod, as well as factors that allow us to assess certain aspects that affect the formation of the range of these drugs in pharmacies.
The purpose of the work was defined as follows: to conduct a study of meeting the demand of the population for groups of medicines intended for the treatment of skin diseases. The conducted analysis shows the following. Drugs intended for the treatment of skin diseases are in high demand (59.09%); 22.73% of drugs are in low demand, the lack of demand was observed in 18.18% of the studied group of drugs.
In this paper, recommendations were formulated to optimize the assortment policy of the World of Medicines pharmacy chain in Belgorod. Since it was determined that high demand drugs such as Argosulfan, Belosalic, Avekort, Cinocap, Candiderm, Alorom, Lomaherpan, and, Nitrofungin. It is for this reason that it is necessary to increase the volume of their purchases to better meet the demand of the population for these drugs.
It was also revealed that it is necessary to reduce the volume of purchases of drugs, the demand for which is reduced. It is drugs such as Daktarin, Adolen, Camadol, Ammifurin, Bramisil, Batrafen, and Hiporhamin (they came in the results of ABC-analysis to the group C). In addition, the pharmacy should promote this group of drugs to familiarize consumers with them and offer them at a reduced price, so as not to burden the turnover of medicines and not to reduce the effectiveness of the pharmacy.
The paper concluded that, according to the study, the demand for medicines used in the treatment of skin diseases is quite high. At the same time, the administration of the pharmacy chain should pay more attention to the analysis of the purchased groups of medicines in this category in order to prevent overloading the pharmacy balance with drugs, the demand for which is reduced, as this negatively affects the effectiveness of the pharmacy organization. In this regard, it is advisable to conduct an ABC analysis of the assortment groups of drugs at least once a quarter, as well as take the necessary measures to promote drugs used in the treatment of skin diseases that are in insufficient demand among the population.
In Silco Study of MIR-124-1 Transcription Factors in Glioblastoma
Authors: Algothmi Khloud M. 
Published: March 2021

MIR-124-1 is a brain-abundant MIRNA, whose expression is important for neuronal tissue division, growth and actions. However, expression of miR-124-1 regulatory mechanisms controlling its actions in neuronal cells in health and diseases still poorly addressed. To understand mechanism for transcriptional and functional regulation of miR-124 in neuronal and glioblastoma cells, this study combined gene expression profiling data and computational transcription factor and microRNA target predictions. The present research focuses on transcription factors and DNA methylation, which are central to miR-124-1 expression regulation. A core promoter sequence of miR-124-1 was predicted to be 500 bp and 100 bp, upstream and downstream of its transcription start sites. Seventy three binding sites of fifty transcription factors in promoter region were found, using MatInspector software. Among these transcription factors, MEIS1, POU3F2, SALL2, ETV1, and MAZ, are known to be brain-enriched transcriptional activators. By using omics data analysis, expression of MAZ, PLAG1 KLF2 as well as a transcriptional repressor ZNF239 showed significant correlation with decline in miR-124-1 expression in glioblastoma cells. Furthermore, a potential CpG island was reported in the promoter, providing another mechanism for transcriptional inhibition of miR-124. As miR-124-1 regulates a number of neuronal physiological and pathological processes, we made an attempt to define its potential targets. A computational prediction of miR-124-1 targets suggested 265 targets with two or more conserved seed sites. Pathway-based analysis of these target genes revealed a significant enrichment for axonal guidance and cancer signaling pathways. At least ten of these targets, SRGAP1, GNAI3, PLXNA3, SEMA5A, SEMA6A, CEBPA, CBL, RASSF5, MITF, and RPS6KB1, showed expected inverse correlation between their expression values and miR-124-1 suppression in glioblastoma cells. Taken together, our data form foundation of subsequent future validation researches for miR-124-1 expression regulation including transcription factors and CpG Island within its promoter as well as functional regulation comprising biological pathways controlled by its target genes.
Health Resource Utilization and Associated Health Care Costs of Biologic Disease‐Modifying Antirheumatic Drugs in German Patients With Psoriatic Arthritis
Authors: Sewerin Philipp , Borchert Kathrin , Meise Dominic , Schneider Matthias , Mahlich Jörg 
Published: March 2021

ObjectiveTo investigate health care costs associated with biologic disease‐modifying antirheumatic drugs (bDMARDs) in a German real‐world cohort of adult biologics‐naive patients with psoriatic arthritis (PsA).MethodsClaims data from the Institute for Applied Health Research Berlin (InGef) research database for patients with a PsA diagnosis and bDMARD claims record (index date) between January 1, 2014, and December 31, 2017, and no bDMARD prescriptions for 365 days before the index date were retrospectively analyzed. Primary outcomes were determination of health care resource utilization and associated annual health care costs for overall and individual bDMARDs in the 12‐month pre‐index and post‐index periods. These outcomes were compared between persistent and nonpersistent groups. Nonpersistence was defined as treatment gap or switch to a bDMARD other than the index therapy.ResultsAmong 10,954 patients with a PsA diagnosis, 348 were eligible. Although mean ± SD post‐index costs were significantly higher in the persistent group than the nonpersistent group (€27,869 ± 8,001 versus €21,897 ± 10,600, P < 0 .001) due to higher bDMARD acquisition costs (€23,996 ± 4,818 versus €16,427 ± 9,033, P < 0.001), persistence reduced inpatient treatment costs (–€760), outpatient treatment costs (–€192), other drug costs (–€724), and sick leave costs (–€601).ConclusionAlthough initiation of bDMARDs increased the total health care costs irrespective of persistence status, partial cost offsets were observed in the persistent patient population.
Synthesis and Local Probe Gating of a Monolayer Metal‐Organic Framework
Authors: Yan Linghao , Silveira Orlando J. , Alldritt Benjamin , Krejčí Ondřej , Foster Adam S. , Liljeroth Peter 
Published: March 2021

AbstractAchieving large‐area uniform 2D metal‐organic frameworks (MOFs) and controlling their electronic properties on inert surfaces is a big step toward future applications in electronic devices. Here a 2D monolayer Cu‐dicyanoanthracene MOF with long‐range order is successfully fabricated on an epitaxial graphene surface. Its structural and electronic properties are studied by low‐temperature scanning tunneling microscopy and spectroscopy complemented by density‐functional theory calculations. Access to multiple molecular charge states in the 2D MOF is demonstrated using tip‐induced local electric fields. It is expected that a similar strategy could be applied to fabricate and characterize 2D MOFs with exotic, engineered electronic states.
Manipulating Nonlinear Optical Response via Domain Control in Nanocrystal‐in‐Glass Composites
Authors: Feng Xu , Lun Yipeng , Jiang Xiaofang , Qiu Jianrong , Yu Huakang , Zhou Shifeng 
Published: March 2021

AbstractNanocrystal‐in‐glass (NIG) is an exciting class of composites, because it can not only combine the advantages of crystal and glass materials but also potentially generate new physical phenomenon in a cooperative manner. Herein, the nonlinear light–matter interaction processes in a broad range of NIG composites homogeneously embedded with LiNbO3 are investigated. It is shown that, by rational control of the organization manner of crystal and glass phases, second‐harmonic generation (SHG) can be precisely tuned. Importantly, an unusual SHG phenomenon, transverse SHG (TSHG), can be realized in the special region of the microstructure map combined with the features of high loading, nanoscale size, and homogenous distribution of nanocrystals. Furthermore, NIG composites exhibit broadband optical response, allowing TSHG in a wide waveband region to be achieved. Based on the above effects, the applications of the constructed NIG composite for precise measurement of the group velocity and duration of ultrashort optical pulses with femtosecond time scales are demonstrated. Indeed, the findings outline a fundamental principle to design NIG configurations for creating new properties, providing new directions for expanding the scope of NIG functional materials.
Multifunctional Reactive Nanocomposites via Direct Ink Writing
Authors: Arlington Shane Q. , Barron Sara C. , DeLisio Jeffery B. , Rodriguez Juan C. , Vummidi Lakshman Shashank , Weihs Timothy P. , Fritz Gregory M. 
Published: March 2021

Abstract3D printing of reactive materials has, to date, primarily focused on controlling reaction velocities and energy release rates by printing novel architectures, which during reaction typically form gaseous and oxide powder products. The utility of printed reactive materials can be increased by designing the material such that its reaction produces both a controlled energy release and a functional product phase without gaseous products. Here, we report the direct ink writing of reactive materials composed of ternary nanocomposite powders that exhibit gasless, exceptionally low velocity reactions. The printed features can be patterned in arbitrary form factors and are brittle and electrically insulating as‐printed. Using a self‐propagating synthesis reaction, these features can be transformed into a mechanically robust, electrically conductive cermet that is capable of handling high currents. This study provides a new paradigm for printing multifunctional reactive materials in which both the energy release of the reaction, as well as the reaction products themselves, are useful for potential applications ranging from printed electronic devices to controlled, directed energy release.
Optical Chirality Detection Using a Topological Insulator Transistor
Authors: Huang Shouyuan , Xu Xianfan 
Published: March 2021

AbstractOptical chirality is an effective means in screening molecules and their enantiomers in bioengineering, and recently has garnered attention as an implementation of qubits in quantum information processing. The conventional detection of circularly polarized light (CPL) is based on phase retardation and polarization separation using multiple optical components. An intrinsic solid‐state chirality detection device would be favorable for easier integration and implementation. Optical spin injection to the spin‐momentum‐locked topological surface states of topological insulators (TIs) by circularly polarized light leads to a directional DC photocurrent and hence possible circular polarization detection. However, this DC photocurrent is also accompanied by other photo‐responses. Here, a photodetection strategy using a TI transistor which senses CPL without the use of any additional components is demonstrated, it achieves a uniform response over the entire device with a sensitivity ≈5.6%. The Stokes parameters can also be extracted by arithmetic operation of photocurrents obtained with different bias and gate for a complete characterization of a polarized light beam. Therefore, this method enables chirality detection and Stokes parameter analysis using a single device. The proposed miniaturized intrinsic chirality detectors facilitate polarimetry sensing in applications from circular dichroism spectroscopy to biomedical diagnosis.
Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants
Authors: Beckers Sebastian J. , Staal Alexander H. J. , Rosenauer Christine , Srinivas Mangala , Landfester Katharina , Wurm Frederik R. 
Published: March 2021

AbstractSpraying of agrochemicals (pesticides, fertilizers) causes environmental pollution on a million‐ton scale. A sustainable alternative is target‐specific, on‐demand drug delivery by polymeric nanocarriers. Trunk injections of aqueous nanocarrier dispersions can overcome the biological size barriers of roots and leaves and allow distributing the nanocarriers through the plant. To date, the fate of polymeric nanocarriers inside a plant is widely unknown. Here, the in planta conditions in grapevine plants are simulated and the colloidal stability of a systematic series of nanocarriers composed of polystyrene (well‐defined model) and biodegradable lignin and polylactic‐co‐glycolic acid by a combination of different techniques is studied. Despite the adsorption of carbohydrates and other biomolecules onto the nanocarriers’ surface, they remain colloidally stable after incubation in biological fluids (wood sap), suggesting a potential transport via the xylem. The transport is tracked by fluorine‐ and ruthenium‐labeled nanocarriers inside of grapevines by 19F‐magnetic resonance imaging or induced coupled plasma – optical emission spectroscopy. Both methods show that the nanocarriers are transported inside of the plant and proved to be powerful tools to localize nanomaterials in plants. This study provides essential information to design nanocarriers for agrochemical delivery in plants to sustainable crop protection.
Micromixing in a gas–liquid vortex reactor
Authors: Ouyang Yi , Manzano Manuel Nunez , Beirnaert Koenraad , Heynderickx Geraldine J. , Van Geem Kevin M. 
Published: March 2021

AbstractThe gas–liquid vortex reactor (GLVR) has substantial process intensification potential for multiphase processes. Essential in this respect is the micromixing efficiency, which is of great importance in fast reaction systems such as crystallization, polymerization, and synthesis of nanomaterials. By creating a vortex flow and taking advantage of the centrifugal force field, the liquid micromixing process can be intensified in the GLVR. Results show that introducing a liquid into a gas‐only vortex unit results in suppression of primary and secondary gas flow. The Villermaux–Dushman protocol is applied to study the effects of the gas flow rate, liquid flow rate, and liquid viscosity based on a segregation index. Based on the incorporation model and reaction kinetics, the micromixing time of the GLVR is determined to be in the range of 10−4 ~ 10−3 s, which is comparable to the highly efficient rotating packed bed and substantially better than a static mixer.
First prenatal case of Noonan syndrome with SOS2 mutation: Implications of early diagnosis for genetic counseling
Authors: Gentile Mattia , Fanelli Tiziana , Lepri Francesca Romana , Gentile Angela , Orsini Paola , Volpe Paolo , Novelli Antonio , Ficarella Romina 
Published: March 2021

AbstractRASopathies are a group of syndromes with partially overlapping clinical features caused by germline mutations of the RAS/MAPK signaling pathway genes. The most common disorder is Noonan syndrome (NS; MIM 163950). We report the first prenatal case of NS with SOS2 (NM_006939.4) mutation in a euploid fetus with a severe increase in nuchal translucency (NT > 12 mm). Trio‐based custom next‐generation sequencing detected a de novo heterozygous missense mutation in the SOS2 gene: c.800 T > A (p.Met267Lys). Owing to the marked variable expressivity of NS and the scarcity of SOS2 mutation‐related NS cases reported in the literature, it is difficult to provide appropriate genetic counseling. Several issues such as the best management technique and optimal NT cutoff have been discussed. In addition, in general, the fine balance between the advantages of an early prenatal diagnosis and the challenge of determining if the detected gene variant is pathogenic and, primarily, the stress of the counselees when providing a genetic counseling with limited information on the prenatal phenotype have been discussed. A prenatal path comprising examinations and multidisciplinary counseling is essential to support couples in a shared decision‐making process.
Acceleration of Reverse Intersystem Crossing using Different Types of Charge Transfer States
Authors: Wada Yoshimasa , Nakagawa Hiromichi , Kaji Hironori 
Published: March 2021

AbstractThere is a need to boost the rate constant of reverse intersystem crossing (kRISC) in thermally activated delayed fluorescence (TADF) materials for applications to organic light‐emitting diodes. Recently, energy level matching of the locally excited state (LE) and charge transfer state (CT) has been reported to enhance kRISC. In this study, we conceptually demonstrate that kRISC can be improved even between CT states without LE states, through the use of different types of CT states. On the basis of this concept, we design a new compound, named DMAC‐bPmT, where two phenyl groups of a well‐known TADF material DMAC‐TRZ are substituted by pyrimidine groups. Theoretical calculations indicated that the energy levels of the different CT states of DMAC‐bPmT are very close and enhanced spin orbit coupling may be expected between them. As predicted, DMAC‐bPmT experimentally exhibited a kRISC three times as high as that of DMAC‐TRZ.