bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplante Dentário Autógeno – Relato de caso clínico
Authors: Bastos Carlos Eduardo de Jesus , Gomes Ana Viviam Souza Ferro , Leite Thiago Freitas , Cerqueira Caio Cezar Rebouças e 
Published: May 2021

O transplante dentário autógeno dentário é caracterizado pela translocação de um elemento para outro espaço alveolar. É um procedimento considerado como um tratamento reabilitador, com bom prognóstico principalmente para pacientes jovens. Apresentando como grande vantagem o menor custo se comparada com a reabilitação com implantes e próteses fixas, além de grande aceitação pelo paciente por ser um dente próprio, sem envolver materiais “nonself”. O objetivo deste trabalho é expor um relato de caso sobre transplante dentário relacionado com dentes supranumerários em região anterior de maxila. Em que foi realizada a partir de conceitos dos princípios éticos e após assinatura do Termo de Consentimento Livre e Esclarecido (TCLE) pelo responsável. Paciente melanoderma, 14 anos, apresentando elemento supranumerário na região do elemento 11. Após exames imaginológicos pôde-se notar a presença do elemento 11 impactado por palatino. Foi realizada a remoção do supranumerário e do elemento 11, sendo este transplantado para o seu alveolo ideal, sendo mantido em posição com auxílio de contenção semirrígida. No 35º dia pós operatório, o paciente apresentou uma excelente recuperação e cicatrização dos tecidos periodontais. Foi retirada a esplintagem verificando-se boa estabilidade da unidade, sem mobilidade, ausência de sinais flogísticos ou alterações pulpares ao teste de vitalidade. Ao exame radiográfico percebeu-se boa adaptação da raiz, sem sinais de reabsorção. Entretanto, a literatura afirma que este acompanhamento deve ser feito por até 1 ano, objetivando analisar revascularização pulpar e necessidade posterior de endodontia. Até o presente momento, após 2 meses de follow up, o paciente não apresenta sinais de necrose pulpar e está em programação de iniciar o tratamento ortodôntico. Assim, pode-se afirmar que este é um tratamento reabilitador válido e acessível, e quando bem indicado traz bons resultados.
As escolas da Vila: Instituições escolares na Vila da Paz em Teresina (1980-1990)
Authors: Silva Karina Viana da , Sousa Neto Marcelo de 
Published: May 2021

O presente artigo tem como objetivo analisar o surgimento de instituições de ensino no contexto histórico da comunidade Vila da Paz, em Teresina-PI, por meio da análise da atuação socioeducacional de Pedro Balzi, padre que marcou seu sacerdócio em ações missionárias, dentre elas destacando-se a construção de escolas. A pesquisa buscou compreender como a implantação de estabelecimentos educacionais contribuiu para que ocorressem transformações no cenário da Vila. Identificou-se que às ações do clérigo, sobretudo no aspecto educacional, assumiram posição de destaque para a configuração histórica da Vila. Localizada na zona sul de Teresina, o objeto insere-se no recorte de 1980 a 1990, tomando como ponto de partida das análises o contexto social da capital na década de oitenta, marcada pelas ocupações irregulares no tecido urbano. A partir desses recortes, verificou-se que o trabalho desenvolvido por padre Balzi, principalmente por meio da construção de escolas, se revestiu no agente mobilizador das primeiras ações de urbanização na Vila da Paz, modificando o tecido urbano da cidade e do cotidiano de seus moradores. Nesse percurso, procurou-se estabelecer interlocuções com os escritos de Scott Mainwaring, Ana Fani Alessandri Carlos, Maurice Halbwachs, entre outros. Como lastro documental, a pesquisa apoiou-se em fontes bibliográficas, hemerográficas e relatos orais.
Análise epidemiológica e espacial da COVID-19 no Estado do Piauí
Authors: Macedo Glauber Bezerra , Macedo Juliana Bezerra , Garcia Lívia Assis , Ferreira Anderson Fuentes , Macedo Daniela Bezerra , Bortoleto Claudio Scott , Pavinatto Adriana , Tim Carla Roberta 
Published: May 2021

Estudo ecológico, analítico e exploratório que objetivou realizar análises epidemiológicas e espaciais da distribuição dos casos confirmados e dos óbitos por doença do Coronavírus 2019 (do inglês, Coronavírus Disease 2019 - COVID-19) que ocorreram no ano de 2020, no estado do Piauí, Brasil. As variáveis elencadas foram obtidas via banco de dados do IBGE e SESAPI. Nas análises epidemiológicas foram realizadas estatísticas descritivas e nas análises espaciais, foram construídos mapas utilizando técnicas de geoprocessamento, através das análises estatísticas de Moran Global e Local. Os resultados evidenciaram que, no ano de 2020, foram notificados 143.179 casos confirmados e 2.240 óbitos causados por COVID-19 no Piauí. Observou-se maior percentual de casos em indivíduos do sexo feminino, adultos jovens, e os óbitos em idosos, do sexo masculino, com doenças crônicas. Houve formação de clusters no estado, elementos a serem considerados na organização e fortalecimento dos serviços de saúde para o desenvolvimento de estratégias que busquem minimizar a transmissão durante a emergência da COVID-19.
Lomba Kreativitas Tanaman Hidroponik sebagai Strategi dalam Mewujudkan Kampung Hijau di RW 09 Kelurahan Kebon Pala Kota Administrasi Jakarta Timur
Authors: Ulinata Ulinata , Dianty Grace Putri , Hasugian Ajeng ED , Kidingallo Enrique K 
Published: May 2021

Untuk dapat mewujudkan kampung hijau secara perlahan dan mencapai kondisi masyarakat yang hidup sehat terutama pada masa Pandemik COVID 19, serta meningkatkan ketahanan pangan bagi masyarakat yang memiliki keterbatasan lahan, maka hidroponik merupakan pilihan yang tepat.
Program Studi Arsitektur Fakultas Teknik UKI melalui program Pengabdian Pada Masyarakat melakukan kegiatan Green Action 22 Lomba Kreativitas Tanaman Hidroponik sebagai Strategi dalam Mewujudkan Kampung Hijau di RW 09 Kelurahan Kebon Pala Kota Administrasi Jakarta Timur 2020.
Metode yang dilakukan adalah mengadakan lomba kreasi tanaman hidroponik untuk menggiatkan kembali kegiatan berkreasi menanam khususnya hidroponik sehingga perlahan akan dapat meningkatkan ketahanan pangan dan mewujudkan kampung hijau di kelurahan Kebon Pala tersebut.
Prosesnya menyiapkan alat dan bahan yang akan dipergunakan pada saat lomba berupa stereofoam, dua botol nutrisi AB mix, pembolong, selang, netpot, airator, flanel potong, rockwool, benih selada, samhong, TDS, nampan, gelas ukur yang dibagikan kepada para peserta lomba. Waktu perlombaan sekitar 5-6 minggu. Hasilnya adalah pada saat pengumuman pemenang, peserta wajib menunjukkan hasil panen yang sudah dikemas. Kategori pemenang berdasarkan empat kriteria diantaranya tingkat kerapian alat dan media tanam, perkembangan benih, bobot panen yang dihasilkan kemasannya. Selain hadiah, para peserta juga memperoleh edukasi mengenai hidroponik.
Peran Pelatihan Ketahanan dan Motivasi bagi Peningkatan Kinerja Guru Honorer di Kabupaten Bandung Barat
Authors: Bob Foster  , Fitriani Reyta  , Susan Purnama  , Bernadetha Nadeak  , Elfrida Sormin  
Published: May 2021

Untuk mencipakan siswa yang berkualitas salah satunya dengan meningkatkan ketahanan seorang guru. Ketahanan guru dalam menghadapi kondisi sulit perlu menjadi perhatian pimpinan sekolah dalam upaya peningkatan kualitas pendidikan, dengan asumsi ketahanan akan meningkatkan kinerja guru dan menentukan pencapaian tujuan pendidikan. Selain ketahanan guru motivasi dari pihak sekolah juga memiliki peranan penting. Jika motivasi sekolah rendah, maka akan berakibat buruk pada kinerja guru. Dengan adanya fenomena tersebut, terdapat kemungkinan penurunan kinerja guru honorer. Keberhasilan sekolah dalam memperbaiki kinerja guru dapat dipengaruhi pada pemberian pelatihan bagi peningkatan kualitas sumber daya guru dalam bekerja salah satunya pelatihan bagi ketahanan guru dalam mengatasi rintangan mengajar dan menhadapi kondisi sulit. Penelitian kuantitatif ini adalah hasil pengembangan pengabdian kepada masyarakat yang dilakukan oleh akademisi dari fakultas ekonomi dan bisnis Universitas Informatika dan Bisnis Bandung, dengan tujuan menguji pengaruh pelatihan ketahanan guru dan pemberian motivasi terhadap peningkatan kinerja pada 100 (seratus) guru honorer di Kabupaten Bandung Barat. Hipotesis diuji dengan analisis data Partial Least Square (PLS). Hasil menunjukkan bahwa pelatihan ketahanan diri meningkatkan kinerja guru sedangkan motivasi tidak beperan meningkatkan kinerja guru honorer di Kabupaten Bandung Barat.
Characteristics of Ang-(1–7)/Mas-Mediated Amelioration of Joint Inflammation and Cardiac Complications in Mice With Collagen-Induced Arthritis
Authors: Wang Zhongjie , Huang Wenhan , Ren Feifeng , Luo Lei , Zhou Jun , Huang Dongmei , Jiang Mei , Du Huaan , Fan Jinqi , Tang Lin 
Published: May 2021

ObjectivesRheumatoid arthritis (RA) is a disabling disease with a high incidence that is regularly accompanied by cardiovascular complications. Several studies have suggested that renin–angiotensin–aldosterone system (RAAS) is closely associated with RA. The aim of this study was to investigate the mechanisms underlying Angiotensin-(1–7) [Ang-(1–7)] and its Mas receptor agonist (AVE0991) on joint inflammation and cardiac complications in a collagen-induced arthritis (CIA) model.MethodsCollagen type II was injected into DBA/1 mice to construct an arthritis model. CIA mice were treated with Ang-(1–7) (2.0 mg/kg intraperitoneally) and AVE0991 (3.0 mg/kg intraperitoneally). The serum levels of inflammatory cytokines [tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1 β, IL-6, and C-reactive protein (CRP)] were determined by ELISA. The mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-κB) signaling pathways in joint tissues and the transforming growth factor (TGF)-β/Smad pathway and levels of α-Smooth muscle action (SMA) and β-myosin heavy chain (MHC) protein expression in cardiac tissues were assessed by western blots. The levels of TGF-β/Smad pathway, α-SMA, and β-MHC RNA in cardiac tissues were analyzed by real time-PCR. The levels of receptor activator of nuclear factor kappa ligand (RANKL) and promoting matrix metalloproteinase (MMP)-3 expression in the ankle joints were detected by immunohistochemistry and real time-PCR.ResultsAng-(1–7) and AVE0991 reduced the levels of inflammatory cytokines and inhibited the MAPKs and NF-κB signaling pathways in ankle joint tissues, reduced RANKL and MMP3 expression, and ameliorated local joint inflammation and bone destruction compared with the control group. In addition, Ang-(1–7) and AVE0991 attenuated the TGF-β/Smad signaling pathway, reduced the levels of α-SMA and β-MHC expression, and diminished inflammatory cell infiltration into the myocardial interstitium and myocardial interstitial fibrosis in the hearts of CIA mice.ConclusionsAng-(1–7) alleviated joint damage caused by inflammation likely through the attenuation of NF-κB and MAPK pathways and ameliorated inflammation-induced cardiac fibrosis and activation of the TGF-β/Smad pathway. Moreover, Ang-(1–7) was likely mediated through the Mas receptor. This study provides theoretical evidence for exploring novel clinical therapeutic approaches for RA and its cardiac complications.
CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p/SLC2A1 Axis in Glioblastoma Multiform
Authors: Li Wen , Wang Shanshan , Shan Boquan , Cheng Xiang , He Hui , Qin Jianbing , Tang Yi , Zhao Heyan , Tian Meiling , Zhang Xinhua , Jin Guohua 
Published: May 2021

Glioblastoma multiform (GBM) is the most common and malignant primary brain cancer in adults, and thus, novel potential therapeutic targets for diagnosis and treatment are urgently needed. Circular RNAs (circRNAs) are a class of widespread and diverse endogenous RNAs that have been suggested as potential critical mediators during progression of various tumors. In this study, we investigated the involvement of circHECTD1 in GBM progression. CircHECTD1 Lentivirus, miR-320-5p mimic, and SLC2A1 Lentivirus were transduced into cancer cells independently or together. circHECTD1, miR-320-5p, and SLC2A1 level were detected by qRT-PCR. Western blot and qRT-PCR were applied to measure the expression of SLC2A1, CyclinD1, CDK2, and PCNA. Flow cytometry, EdU, colony formation, Transwell and wound-healing assays were conducted to assess cell proliferation and migration. Luciferase reporter assays were performed to determine the effect of miR-320-5p on circHECTD1 or SLC2A1. Xenograft experiments were implemented to evaluate tumor growth in vivo. CircHECTD1 expression led to the promotion of proliferation and migration of GBM cells. In addition, circHECTD1 acted as a ceRNA to interact with miR-320-5p, which targeted the solute carrier family 2 member 1 (SLC2A1). In vivo experiments also revealed that circHECTD1 promoted tumor growth. Collectively, our findings showed that the circHECTD1-miR-320-5p-SLC2A1 regulatory pathway promoted the progression of GBM, suggesting that circHECTD1 may be a therapeutic target for GBM.
Procalcitonin in Preterm Neonates: A Different Threshold and Prolonged Interpretation
Authors: Bianco Blandine , François-Garret Bérengère , Butin Marine , Dalmasso Cyril , Casagrande Florence , Mokhtari Mostafa , Eleni Dit Trolli Sergio 
Published: May 2021

Objectives: To evaluate the positive threshold of PCT for neonates of &lt;32 weeks of gestation for the diagnosis of early-onset sepsis and to determine if the level of PCT collected within 6 h of life could be used.Design: Retrospective and bicentric study from May 2016 to April 2018.Setting: Two groups were established, neonates evaluated for PCT at birth (CordPCT) and within 6 h of life (delPCT).Patients: Two hundred and sixty neonates of &lt;32 weeks of gestation born in Nice and South Paris (Bicêtre) University Hospitals, had been evaluated for PCT level.Main Outcomes Measures: The value of the PCT positive threshold was determined for the total population and each groups thanks ROC curves.Results: The threshold level of PCT for the total population was 0.98 ng/mL. The threshold value of cordPCT group was 1.00 vs. 0.98 ng/mL for delPCT group. The area under the Receiver Operating Characteristics curve for PCT sampled in delPCT group was significantly higher than in cordPCT group (0.94 compared to 0.75).Conclusions: The threshold level of PCT was higher in this cohort of neonates of &lt;32 weeks of gestation compared to the value generally described for term neonates. The secondary sampling PCT level seems to be usable in screening algorithm for early-onset neonatal sepsis.
Chymase Dependent Pathway of Angiotensin II Generation and Rapeseed Derived Peptides for Antihypertensive Treatment of Spontaneously Hypertensive Rats
Authors: Baranowska Iwona , Gawrys Olga , Roszkowska-Chojecka Malwina M. , Badzynska Bozena , Tymecka Dagmara , Olszynski Krzysztof H. , Kompanowska-Jezierska Elzbieta 
Published: May 2021

The contribution of chymase, one of the enzymes responsible for angiotensin II generation in non-ACE pathway, remains unclear in the development of hypertension. The aim of the study was to investigate chymase inhibition as potential antihypertensive therapy in spontaneously hypertensive rats (SHR). To block chymase we employed chymostatin, a commercial inhibitor, and new analogues of rapeseed-derived peptides, VWIS and RIY. These simple and easy to obtain peptides not only block chymase, but also possess weak activity to inhibit ACE. This is a first attempt to evaluate the impact of chronic administration of selected inhibitors on blood pressure of SHR in two phases of hypertension. Male SHR (6 or 16 weeks old) were treated daily for two weeks with chymostatin (CH; 2 mg/kg/day), the peptides VWIS (12.5 mg/kg/day) or RIY (7.5 mg/kg/day); control groups received chymostatin solvent (0.15% DMSO in saline) or peptide solvent (saline). The substances were administered intravenously to conscious animals via a chronically cannulated femoral vein. Systolic blood pressure (SBP) was measured by telemetry. Metabolic parameters were measured weekly, and tissue samples were harvested after two weeks of treatment. None of the administered chymase inhibitors affected the development of hypertension in young rats. Only RIY exhibited beneficial properties when administered in the established phase of hypertension: SBP decreased from 165 ± 10 to 157 ± 7 mmHg while the excretion of nitric oxide metabolites increased significantly. The glomerulosclerosis index was lower after RIY treatment in both age groups (significant only in young rats 0.29 ± 0.05 vs 0.48 ± 0.04 in the control group; p &lt; 0.05). Hence, it seems that peptide RIY exhibits some positive effect on renal morphology. The results obtained suggest that the peptide RIY may be a useful tool in the treatment of hypertension, especially in cases when ACE inhibitors are not effective.
Tilt Active Vibration Isolation Using Vertical Pendulum and Piezoelectric Transducer with Parallel Controller
Authors: Wu Lihua , Huang Yu , Li Dequan 
Published: May 2021

Tilt vibrations inevitably have negative effects on some precise engineering even after applying horizontal and vertical vibration isolations. It is difficult to adopt a traditional passive vibration isolation (PVI) scheme to realize tilt vibration isolation. In this paper, we present and develop a tilt active vibration isolation (AVI) device using a vertical pendulum (VP) tiltmeter and a piezoelectric transducer (PZT). The potential resolution of the VP is dependent on the mechanical thermal noise in the frequency bandwidth of about 0.0265 nrad, which need not be considered because it is far below the ground tilt of the laboratory. The tilt sensitivity of the device in an open-loop mode, investigated experimentally using a voltage controller, is found to be (1.63±0.11)×105 V/rad. To compensate for the hysteresis nonlinearity of the PZT, we experimentally established the multi-loop mathematical model of hysteresis, and designed a parallel controller consisting of both a hysteresis inverse model predictor and a digital proportional–integral–differential (PID) adjuster. Finally, the response of the device working in close-loop mode to the tilt vibration was tested experimentally, and the tilt AVI device showed a good vibration isolation performance, which can remarkably reduce the tilt vibration, for example, from 6.0131 μrad to below 0.0103 μrad.
A Review of Unreduced Gametes and Neopolyploids in Alfalfa: How to Fill the Gap between Well-Established Meiotic Mutants and Next-Generation Genomic Resources
Authors: Palumbo Fabio , Pasquali Elisa , Albertini Emidio , Barcaccia Gianni 
Published: May 2021

The gene flow mediated by unreduced gametes between diploid and tetraploid plants of the Medicagosativa-coerulea-falcata complex is pivotal for alfalfa breeding. Sexually tetraploidized hybrids could represent the best way to exploit progressive heterosis simultaneously derived from gene diversity, heterozygosity, and polyploidy. Moreover, unreduced gametes combined with parthenogenesis (i.e., apomixis) would enable the cloning of plants through seeds, providing a unique opportunity for the selection of superior genotypes with permanently fixed heterosis. This reproductive strategy has never been detected in the genus Medicago, but features of apomixis, such as restitutional apomeiosis and haploid parthenogenesis, have been reported. By means of an original case study, we demonstrated that sexually tetraploidized plants maintain apomeiosis, but this trait is developmentally independent from parthenogenesis. Alfalfa meiotic mutants producing unreduced egg cells revealed a null or very low capacity for parthenogenesis. The overall achievements reached so far are reviewed and discussed along with the efforts and strategies made for exploiting reproductive mutants that express apomictic elements in alfalfa breeding programs. Although several studies have investigated the cytological mechanisms responsible for 2n gamete formation and the inheritance of this trait, only a very small number of molecular markers and candidate genes putatively linked to unreduced gamete formation have been identified. Furthermore, this scenario has remained almost unchanged over the last two decades. Here, we propose a reverse genetics approach, by exploiting the genomic and transcriptomic resources available in alfalfa. Through a comparison with 9 proteins belonging to Arabidopsis thaliana known for their involvement in 2n gamete production, we identified 47 orthologous genes and evaluated their expression in several tissues, paving the way for novel candidate gene characterization studies. An overall view on strategies suitable to fill the gap between well-established meiotic mutants and next-generation genomic resources is presented and discussed.
Increased Mortality Associated with Hypermagnesemia in Severe COVID-19 Illness
Authors: Stevens Jacob S. , Moses Andrew A. , Nickolas Thomas L. , Husain Syed Ali , Mohan Sumit 
Published: May 2021

Abstract

Key Points

Hypermagnesemia is common in patients admitted with coronavirus disease 2019.The development of hypermagnesemia in coronavirus disease 2019 is associated with renal failure and markers of high cell turnover.In adjusted models, patients who develop hypermagnesemia have an increased risk of mortality.

Background
Although electrolyte abnormalities are common among patients with COVID-19, very little has been reported on magnesium homeostasis in these patients. Here we report the incidence of hypermagnesemia, and its association with outcomes among patients admitted with COVID-19.

Methods
We retrospectively identified all patients with a positive test result for SARS-CoV-2 who were admitted to a large quaternary care center in New York City in spring 2020. Details of the patients’ demographics and hospital course were obtained retrospectively from medical records. Patients were defined as having hypermagnesemia if their median magnesium over the course of their hospitalization was >2.4 mg/dl.

Results
A total of 1685 patients hospitalized with COVID-19 had their magnesium levels checked during their hospitalization, and were included in the final study cohort, among whom 355 (21%) had hypermagnesemia. Patients who were hypermagnesemic had a higher incidence of shock requiring pressors (35% vs 27%, P<0.01), respiratory failure requiring mechanical ventilation (28% vs 21%, P=0.01), AKI (65% vs 50%, P<0.001), and AKI severe enough to require renal replacement therapy (18% vs 5%, P<0.001). In an adjusted multivariable model, hypermagnesemia was observed more commonly with increasing age, male sex, AKI requiring RRT, hyperkalemia, and higher CPK. Survival probability at 30 days was 34% for the patients with hypermagnesemia, compared with 65% for patients without hypermagnesemia. An adjusted multivariable time to event analysis identified an increased risk of mortality with older age, need for vasopressors, higher C-reactive protein levels, and hypermagnesemia (HR, 2.03; 95% CI, 1.63 to 2.54, P<0.001).

Conclusions
In conclusion, we identified an association between hypermagnesemia among patients hospitalized with COVID-19 and increased mortality. Although the exact mechanism of this relationship remains unclear, hypermagnesemia potentially represents increased cell turnover and higher severity of illness, which is frequently associated with more severe forms of AKI.