bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Binocular Accommodative Function in Children With Different Types of Intermittent Exotropia
Authors: Li Dan , Li Kun-Ling , Wang Jing , Du Lin-Lin , Li Li 
Published: October 2021

Objective: This study aims to investigate the monocular and binocular accommodative amplitude (AMP) and accommodative function (AF) in children with different types of intermittent exotropia (IXT).Methods: A total of 40 children with IXT were enrolled in the study. Monocular and binocular AMP and AF were measured using the modified approach method and the ±2D flip method, and the differences between the fixing and non-fixing eyes of non-strabismic children and children with different types of IXT were compared.Results: The AMP of the fixing eyes of children with IXT was lower than that of their non-fixing eyes (p = 0.007). Conversely, the AF was higher in the fixing eyes than in the non-fixing eyes (p &lt; 0.001). The AMPs of each group of children with IXT were lower than those of the control group, while the AMP of the group with convergence insufficiency was lower than that of the other two groups with IXT. In addition, the AF of the group with convergence insufficiency was lower than that of the group with basic exotropia and the control group (p &lt; 0.05).Conclusion: There is a difference in accommodation between the fixing and non-fixing eyes of children with IXT, and the degree of variation depends on the type of IXT. Moreover, the binocular accommodative function of children with IXT is lower than that of non-strabismic children.
Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome
Authors: Mehboob Riffat , Kurdi Maher , Ahmad Mursleen , Gilani Syed Amir , Khalid Sidra , Nasief Hisham , Mirdad Abeer , Malibary Husam , Hakamy Sahar , Hassan Amber , Alaifan Meshari , Bamaga Ahmed , Shahzad Syed Adnan 
Published: October 2021

Background:Sudden infant death syndrome (SIDS) is a tragic incident which remains a mystery even after post-mortem investigation and thorough researches.Methods:This comprehensive review is based on the genes reported in the molecular autopsy studies conducted on SIDS so far. A total of 20 original studies and 7 case reports were identified and included in this analysis. The genes identified in children or adults were not included. Most of the genes reported in these studies belonged to cardiac channel and cardiomyopathy. Cardiac channel genes in SIDS were scrutinized for further analysis.Results:After screening and removing the duplicates, 42 unique genes were extracted. When the location of these genes was assessed, it was observed that most of these belonged to Chromosomes 11, 1 and 3 in sequential manner. The pathway analysis shows that these genes are involved in the regulation of heart rate, action potential, cardiac muscle cell contraction and heart contraction. The protein-protein interaction network was also very big and highly interactive. SCN5A, CAV3, ALG10B, AKAP9 and many more were mainly found in these cases and were regulated by many transcription factors such as MYOG C2C1 and CBX3 HCT11. Micro RNA, “hsa-miR-133a-3p” was found to be prevalent in the targeted genes.Conclusions:Molecular and computational approaches are a step forward toward exploration of these sad demises. It is so far a new arena but seems promising to dig out the genetic cause of SIDS in the years to come.
The Genetic Etiology Diagnosis of Fetal Growth Restriction Using Single-Nucleotide Polymorphism-Based Chromosomal Microarray Analysis
Authors: Chen Yu'e , Xie Yingjun , Jiang Yuying , Luo Qi , Shi Lijing , Zeng Shuhong , Zhuang Jianlong , Lyu Guorong 
Published: October 2021

Background: An increase in pathogenic copy number variants (pCNVs) has been recognized to associate with fetal growth restriction (FGR). Here, we aim to explore the application value of chromosomal microarray analysis (CMA) in prenatal diagnosis of FGR.Methods: Prenatal ultrasound was applied to identify FGR. A total of 149 pregnant women with FGR were enrolled in our study. All subjects underwent karyotype analysis and CMA to reveal the chromosomal abnormalities.Results: In this study, all subjects were successfully detected by karyotype and CMA analyses. Of these subjects, the chromosomal abnormalities detection rate was 5.37% (8/149) for karyotyping and 13.42% (20/149) for CMA, respectively. Among them, an 8.05% (12/149) incremental yield of CMA over karyotype analysis was observed (p = 0.004). In addition, a significant difference of pCNV detection rate was observed between the groups with different high-risk factors (p = 0.005). The FGR with structural anomalies group showed the highest pCNV detection rate (33.33%), followed by the FGR with non-structural anomalies group (8.77%) and the isolated FGR group (8.06%).Conclusion: In conclusion, CMA technology showed an effective application value in etiology diagnosis of FGR. We believe that CMA should be recommended as first-line detection technology for prenatal diagnosis in FGR.
Outcomes and Prognostic Factors for Survival of Neonates With Necrotizing Enterocolitis
Authors: Siahaan Elena Sophia Elekta Dilean , Adriansyah Wahyudhy , Sasmita Andika Purba , Fauzi Aditya Rifqi , Dwihantoro Andi , Gunadi  
Published: October 2021

Background: Due to the survival of preterm neonates being continually improved, the modifiable prognostic factors of necrotizing enterocolitis (NEC) are essential to be investigated and considered in making a suitable treatment to decrease the prevalence and effect of NEC. Many prognostic factors have been associated with the survival of neonates with NEC; however, the studies show conflicting results. Moreover, the study from developing countries regarding NEC outcomes is minimal. Here, we aimed to determine the survival of neonates with NEC and associate it with the prognostic factors.Methods: A retrospective study was conducted using medical records of neonates with NEC at our institution from January 2014 to December 2019.Results: Fifty-two neonates with NEC were involved with the overall survival of 44.2%. Log-rank analysis showed that NEC staging and birth weight were significantly associated with the survival of neonates with NEC with a p-value of 0.010 and 0.002, respectively, while sex, APGAR score, platelet count, and type of treatment were not (p = 0.068, 0.752, 0.087, and 0.343, respectively). Multivariate analysis revealed that sex and NEC staging were strongly associated with the survival of neonates with NEC with a p-value of 0.018 [HR = 3.10 (95% CI = 1.21–7.93)] and 0.019 [HR = 0.44 (0.22–0.87)], respectively.Conclusions: Our study shows that sex and NEC staging might affect the survival of neonates with NEC. It implies that NEC staging should be closely monitored and intervened as early as necessary to prevent further morbidity and mortality.
Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis
Authors: Shi Hongwei , Tang Heng , Ai Wen , Zeng Qingfu , Yang Hong , Zhu Fengqing , Wei Yunjie , Feng Rui , Wen Li , Pu Peng , He Quan 
Published: October 2021

Objective: Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various cancers, but its cardiotoxicity cannot be ignored. Schisandrin B (SchB) has the ability to upregulate cellular antioxidant defense mechanism and promote mitochondrial function and antioxidant status. However, it has not been reported whether it can resist THP-induced cardiotoxicity. The aim of this study was to investigate the effect of SchB on THP cardiotoxicity and its mechanism.Methods: The rat model of cardiotoxicity induced by THP was established, and SchB treatment was performed at the same time. The changes of ECG, cardiac coefficient, and echocardiogram were observed. The changes of myocardial tissue morphology were observed by H&amp;E staining. Apoptosis was detected by TUNEL. The levels of LDH, BNP, CK-MB, cTnT, SOD, and MDA in serum were measured to observe the heart damage and oxidative stress state of rats. The expression of cleaved-caspase 9, pro/cleaved-caspase 3, Bcl-2/Bax, and cytosol and mitochondrial Cyt C and Bax was evaluated by western blot. H9c2 cardiomyocytes were cocultured with THP, SchB, and mPTP inhibitor CsA to detect the production of ROS and verify the above signaling pathways. The opening of mPTP and mitochondrial swelling were detected by mPTP kit and purified mitochondrial swelling kit.Results: After 8 weeks, a series of cardiotoxicity manifestations were observed in THP rats. These adverse effects can be effectively alleviated by SchB treatment. Further studies showed that SchB had strong antioxidant and antiapoptotic abilities in THP cardiotoxicity.Conclusion: SchB has an obvious protective effect on THP-induced cardiotoxicity. The mechanism may be closely related to the protection of mitochondrial function, inhibition of mPTP opening, and alleviation of oxidative stress and apoptosis of cardiomyocytes.
The Second Wind in McArdle Patients: Fitness Matters
Authors: Salazar-Martínez Eduardo , Santalla Alfredo , Valenzuela Pedro L. , Nogales-Gadea Gisela , Pinós Tomàs , Morán María , Santos-Lozano Alejandro , Fiuza-Luces Carmen , Lucia Alejandro 
Published: October 2021

Background: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. In this regard, an increase in the workload eliciting the SW could potentially translate into an improved patients’ exercise tolerance in daily life. We aimed to determine whether aerobic fitness and physical activity (PA) levels are correlated with the minimum workload eliciting the SW in McArdle patients—as well as with the corresponding heart rate value. We also compared the SW variables and aerobic fitness indicators in inactive vs. active patients.Methods: Fifty-four McArdle patients (24 women, mean ± SD age 33 ± 12 years) performed 12-min constant-load and maximum ramp-like cycle-ergometer tests for SW detection and aerobic fitness [peak oxygen uptake (VO2peak) and workload and ventilatory threshold] determination, respectively. They were categorized as physically active/inactive during the prior 6 months (active = reporting ≥150 min/week or ≥75 min/week in moderate or vigorous-intensity aerobic PA, respectively) and were also asked on their self-report of the SW.Results: Both peak and submaximal indicators of aerobic fitness obtained in the ramp tests were significantly correlated with the workload of the SW test, with a particularly strong correlation for the VO2peak and peak workload attained by the patients (both Pearson’s coefficients &gt; 0.70). Twenty (seven women) and 24 patients (18 women) were categorized as physically active and inactive, respectively. Not only the aerobic fitness level [∼18–19% higher values of VO2peak (ml⋅kg–1⋅min–1)] but also the workload of the SW tests was significantly higher in active than in inactive patients. All the inactive patients reported that they experienced the SW during walking/brisk walking in daily life, whereas active patients only reported experiencing this phenomenon during more strenuous activities (very brisk walking/jogging and bicycling).Conclusion: A higher aerobic fitness and an active lifestyle are associated with a higher workload eliciting the so-called SW phenomenon in patients with McArdle disease, which has a positive impact on their exercise tolerance during daily living.
Psychological Adjustment, Quality of Life and Well-Being in a German and Portuguese Adult Population During COVID-19 Pandemics Crisis
Authors: Candeias Adelinda , Galindo Edgar , Stueck Marcus , Portelada António , Knietzsch Jessica 
Published: October 2021

Introduction: The pandemics crisis had consequences in psychological adjustment of persons all over the world. The current study analyzes comparatively the topics of quality of life, and well-being, considering as predictors trait anxiety, feeling of threat, difficulty to relax, empathy and pro-social attitude, health care, sleep quality and optimism, in a population of German and Portuguese adults during the pandemics, in order to obtain a deeper understanding of the psychological reactions to crisis across countries and cultures.Methods: A sample of 470 adults divided in three age groups – —young adults (18—34 years), middle-age adults (34–54 years) and old adults (55 years and older)— completed a self-report questionnaire assessing socio-demographic data, quality of life, well-being, quality of sleep, trait anxiety, Coronavirus threat, optimism regarding the pandemics, difficulty to relax, empathy, and pro-social attitude during the pandemics period.Results: Portuguese participants expresses higher empathy and pro-social attitude and health care but in Germany people have higher quality of sleep. Young adults (a) rated their quality of life lower than middle-age adults and old adults, (b) showed also lower optimism than middle-age and old adults, and (c) showed lower well-being than middle-age,.Conclusions: Young adults rated their quality of life, optimism and well-being during pandemics lower than middle-age and old adults, and experienced higher levels of trait anxiety and difficulty to relax. It seems that young adults show a lower psychological adjustment than other age groups during COVID-19 crisis. It is concluded that quality of life, optimism, and well-being during the pandemics are affected differently according to country and group of age, suggesting individual differences across cultures and ages, and consequently the need of specific interventions to cope with the psychological reactions to pandemics crisis.
Inequalities in Knowledge About COVID-19 in the Kingdom of Saudi Arabia
Authors: Alsharqi Omar Zayyan , Qattan Ameerah M. N. , Alshareef Noor , Chirwa Gowokani Chijere , Al-Hanawi Mohammed Khaled 
Published: October 2021

Background: As the world is still being ravaged by the coronavirus disease 2019 (COVID-19) pandemic, the first line of prevention lies in understanding the causative and preventive factors of the disease. However, given varied socioeconomic circumstances, there may be some inequality in the level of proper knowledge of COVID-19. Despite a proliferation of studies on COVID-19, the extent and prevalence of inequalities in knowledge about COVID-19 in Saudi Arabia are not known. Most related studies have only focused on understanding the determinants of COVID-19 knowledge. Therefore, the aim of this study was to assess the socioeconomic inequalities in knowledge regarding COVID-19 in Saudi Arabia.Methods: Data were extracted from an online cross-sectional self-reported questionnaire conducted on the knowledge about COVID-19 from 3,388 participants. Frequencies and graphs were used to identify the level and distribution of inequality in knowledge about COVID-19. Concentration curves and concentration indices were further used to assess and quantify the income- and education-related inequality in knowledge about COVID-19.Results: The level of COVID-19 knowledge was high among the surveyed sample, although the extent of knowledge varied. The findings further suggest the existence of socioeconomic inequality in obtaining proper knowledge about COVID-19, indicating that inequality in comprehensive knowledge is disproportionately concentrated among the wealthy (concentration index = 0.016; P &lt; 0.001) and highly educated individuals (concentration index = 0.003; P = 0.029) in Saudi Arabia.Conclusions: There is inequality in the level of knowledge about COVID-19 among the more socioeconomically privileged population of Saudi Arabia. Given that COVID-19 cases ebb and flow in different waves, it is important that proper policies be put in place that will help in improving knowledge among the lower income and less educated individuals, leading to behavior that can help reduce transmission.
Performance Enhancement of mm-Wave Phased Arrays for Mobile Terminals Through Grounded Coplanar Waveguide Feeding Networks With via Fences
Authors: Lee Jae-Yeong , Choi Jaehyun , Kim Bumhyun , Oh Yerim , Hong Wonbin 
Published: October 2021

This paper presents a design methodology focused on feeding networks that can improve the insertion loss and coverage efficiencies of millimeter-wave (mm-Wave) phased arrays in mobile terminals. This enhancement is accomplished by using a grounded coplanar waveguide (GCPW) transmission line (TL) withviafences fabricated on single-layer FR-4 PCB. The exemplified 8-element phased arrays incorporating a compact one-dimensional electromagnetic bandgap (1-D EBG) antenna are fed through a 1 × 8 T-junction power divider, which includes the predetermined phased delay lines. To achieve high radiation performance with minimum leakage power or spurious waves in the T-junction power divider, an island-shape GCPW TL topology withviafences featuring high-impedance surfaces (HIS) is devised and fabricated. For further investigation on the radiation performance and spherical coverage of the mm-Wave mobile antenna, a mobile device prototype equipped with two sets of the 8-element phased arrays is prepared and studied. Through extensive simulation and experimental studies, it can be ascertained that the proposed GCPW TL topology withviafences can improve the realized gain at a coverage efficiency of 50% by more than 3 dB, between 26 and 36 GHz.
Comprehensive Analysis to Identify the Epithelial–Mesenchymal Transition-Related Immune Signatures as a Prognostic and Therapeutic Biomarkers in Hepatocellular Carcinoma
Authors: Wu Guozhi , Yang Yuan , Zhu Yu , Li Yemao , Zhai Zipeng , An Lina , Liu Min , Zheng Ya , Wang Yuping , Zhou Yongning , Guo Qinghong 
Published: October 2021

Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with the high rates of the morbidity and mortality due to the lack of the effective prognostic model for prediction.Aim: To construct a risk model composed of the epithelial–mesenchymal transition (EMT)-related immune genes for the assessment of the prognosis, immune infiltration status, and chemosensitivity.Methods: We obtained the transcriptome and clinical data of the HCC samples from The Cancer Genome Atlas (TCGA) and The International Cancer Genome Consortium (ICGC) databases. The Pearson correlation analysis was applied to identify the differentially expressed EMT-related immune genes (DE-EMTri-genes). Subsequently, the univariate Cox regression was introduced to screen out the prognostic gene sets and a risk model was constructed based on the least absolute shrinkage and selection operator-penalized Cox regression. Additionally, the receiver operating characteristic (ROC) curves were plotted to compare the prognostic value of the newly established model compared with the previous model. Furthermore, the correlation between the risk model and survival probability, immune characteristic, and efficacy of the chemotherapeutics were analyzed by the bioinformatics methods.Results: Six DE-EMTri-genes were ultimately selected to construct the prognostic model. The area under the curve (AUC) values for 1-, 2-, and 3- year were 0.773, 0.721, and 0.673, respectively. Stratified survival analysis suggested that the prognosis of the low-score group was superior to the high-score group. Moreover, the univariate and multivariate analysis indicated that risk score [hazard ratio (HR) 5.071, 95% CI 3.050, 8.432; HR 4.396, 95% CI 2.624, 7.366; p &lt; 0.001] and stage (HR 2.500, 95% CI 1.721, 3.632; HR 2.111, 95% CI 1.443, 3.089; p &lt; 0.001) served as an independent predictive factors in HCC. In addition, the macrophages, natural killer (NK) cells, and regulatory T (Treg) cells were significantly enriched in the high-risk group. Finally, the patients with the high-risk score might be more sensitive to cisplatin, doxorubicin, etoposide, gemcitabine, and mitomycin C.Conclusion: We established a reliable EMTri-genes-based prognostic signature, which may hold promise for the clinical prediction.
Long-Term Follow-Up of Lichtenstein Repair of Inguinal Hernia in the Morbid Patients With Self-Gripping Mesh (ProgripTM)
Authors: Zhang Weiyu , Zhao Yixin , Shao Xiangyu , Cheng Tao , Ji Zhenling , Li Junsheng 
Published: October 2021

Objective: This study aimed to demonstrate the safety and the efficacy of the self-gripping mesh (ProgripTM) for inguinal hernia repair in morbid patients of the higher American Society of Anesthesiologists (ASA) classification (ASA III and IV). The incidence of chronic pain, postoperative complications, and hernia recurrence was evaluated.Methods: Data were collected retrospectively from the files of the patient and were analyzed for 198 hernias in 147 patients. All the patients included in this study had undergone inguinal hernia repair by Lichtenstein approach with the self-gripping mesh (ProgripTM) in the same clinical center. Preoperative, perioperative, and postoperative data were collected and a long-term follow-up of 31.8 ± 19.5 m (5–60 m) was performed. Complications, pain scored on a 0–10 numeric rating scale (NRS), and hernia recurrence were assessed.Results: During the past 5 years, 198 hernias in 147 patients were repaired with the Lichtenstein procedure with the self-gripping mesh (ProgripTM). The majority of the patients were high level of the ASA classification (ASA III and IV) (95.9%), with ASA III (10.2%) and IV (85.7%). The mean operation time was 71.2 ± 23.8 min. The mean length of postoperative stay was 2.5 ± 2.1 days. There were no intraoperative complications. About 14 cases (7.1%) suffered from postoperative surgical wound complications, which were limited to the skin and subcutaneous tissue and were cured with the conservative methods successfully; there was no mesh infection, the acute postoperative pain was low or mild [visual analog scale (VAS) score ≤ 4] and the chronic postoperative pain was reported in three patients (1.5%) and tolerable, hernia recurrence (femoral hernia recurrence) occurred in one patient half a year after during the follow-up period.Conclusion: This study demonstrated the advantages of the self-gripping mesh in hernia repair of the high-risk patients with inguinal hernia (ASA III and IV) by Lichtenstein procedure under local anesthesia.
Кримінологічна характеристика осіб, які вчинили погрозу або насильство щодо працівника правоохоронного органу
Authors: Беленок В. 
Published: October 2021

У статті на підставі аналізу судової практики, статистичних даних, результатів досліджень учених розкрито особливості кримінальних правопорушників цієї категорії за ознаками громадянства, національності, віку, статі, освітнього рівня, судимості, співучасті, фізичного стану, працевлаштування та місця проживання. Розроблено кримінологічний портрет особи, яка вчиняє погрози або насильство щодо працівників правоохоронних органів у зв'язку з виконанням цим працівником службових обов'язків: чоловік у віці 25–50 років, громадянин України, місцевий мешканець міста, з загальною середньою або професійно-технічною освітою, котрий офіційно не працевлаштований, зловживає алкогольними напоями та раніше вчинив адміністративне чи кримінальне правопорушення (у певних випадках раніше судимий).