bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting the CROPGRO model to simulate growth and production of Brassica carinata, a bio‐fuel crop
Authors: Boote Kenneth J. , Seepaul Ramdeo , Mulvaney Michael J. , Hagan Austin K. , Bashyal Mahesh , George Sheeja , Small Ian , Wright David L. 
Published: May 2021

AbstractCarinata (Brassica carinata) is an oilseed crop which, because of its non‐edible oil composition and favorable fatty acid profile, is proposed as a “green” sustainable aviation fuel. It can be grown as a winter crop in the southeastern USA or as a summer annual crop in northern latitudes. No crop models exist for carinata because it is a relatively new crop. The CROPGRO model is a mechanistic crop simulation of daily crop growth and development as a function of daily weather, soil properties, crop management, and species parameters. We adapted the CROPGRO model to simulate carinata based on growth analysis data collected over two seasons at three sites: Quincy, FL, Jay, FL, and Shorter, AL. The adaptation process required literature knowledge as well as optimization against field observations. The parameterization of model sensitivities to climatic factors is presented. The adapted model gave good simulations of carinata growth dynamics compared to observed growth during different seasons and locations and in response to N fertilization. While additional testing is appropriate, the model is sufficiently ready to be used for various applications. An example application is presented for the effect of sowing date on carinata yield and maturity over long‐term weather in the Southeastern USA.
The SLIM study—Shared medical appointments to change lifestyles of overweight people with haemophilia: A randomized multiple baseline (n‐of‐1) design
Authors: Hendriks Marcel A. L. , van Wanroij Johanna W. M. , Laros‐van Gorkom Britta A. P. , Nijhuis‐van der Sanden Maria W. G. , Hoogeboom Thomas J. 
Published: May 2021

AbstractIntroductionPeople with haemophilia suffer from haemophilic joint disease that may result in physical inactivity and overweight. Shared medical appointments (SMAs) might help limit the consequences of haemophilic arthropathy. SMAs are group meetings supervised by one or more healthcare professionals that can be utilized to improve lifestyle.AimTo evaluate the feasibility and efficacy of SMAs in people with haemophilia to improve physical activity and eating habits.MethodsA multiple baseline single‐case design was used. Overweight people with haemophilia were eligible to participate. Seven weekly SMAs were conducted using multiple behavioural change techniques to improve physical activity and eating habits. Feasibility of SMAs was evaluated using (a) dropout rate, (b) occurrence of adverse events (AEs), (c) adherence rate and (d) patient satisfaction. During 13 weeks, physical activity was measured daily and eating habits were measured three times per week. The efficacy of SMAs was determined using randomization tests and visual data inspection.ResultsOut of the six men participating in the study, one participant dropped out. No study‐related AEs occurred. The adherence rate of SMAs was 80%, and participants reported to be ‘very satisfied’ with the SMAs. Randomization tests and visual analyses demonstrated (statistical) improvements in physical activity (p = .03). No effect was found in self‐reported eating habits (p = .55).ConclusionShared medical appointments are feasible in people with haemophilia and appear to improve physical activity. The effect on improving eating habits could not be established. Scientific replication of our approach is warranted to confirm or refute the merit of SMAs in people with haemophilia.
Applied Linguistics, language guidelines, and inclusive practices: The case for the use of who with nonhuman animals
Authors: Chau Meng Huat , Jacobs George M. 
Published: May 2021

AbstractTo promote a more open and more self‐aware Applied Linguistics, we can consider how the many current and developing initiatives and resources in the field can be instruments for achieving a better world. For instance, applied linguists have examined such issues as inclusiveness (e.g., avoiding generic he) and the interface between language and environmental destruction. The purpose of this article, based on the same spirit of inclusiveness and addressing global concerns, is to highlight an observation about the instruction on the restrictive use of “who” with human beings in the recent seventh edition of the Publication manual of the American Psychological Association (2020), as a case in point to contribute to the wider discussion on inclusive language use and a respect for nonhuman animals. We invite fellow applied linguists to reflect on this issue together.
Individual disagreement point concavity and the bargaining problem
Authors: Bossert Walter , Peters Hans 
Published: May 2021

AbstractIn this study, we provide a characterization of the class of proportional bargaining solutions introduced by Kalai. Our result differs from earlier axiomatizations in that we use a property that we label individual disagreement point concavity. This property is a weakening of disagreement point concavity used by Chun and Thomson. An application illustrates the potential usefulness of our new property in a strategic setting.
Memory Matters: Ressourcement Theology’s Debt to Henri Bergson
Authors: Martin Jennifer Newsome 
Published: May 2021

AbstractThe purpose of this article is to illuminate certain lines and layers of readings and rereadings – specifically running from Jewish philosopher Henri Bergson (1859–1941) through Catholic poet Charles Péguy (1873–1914) to Hans Urs von Balthasar – to suggest that certain fundamental ressourcement concepts of tradition and history are conditioned constitutionally by Bergsonian metaphysics, epistemology and theories of time. Péguy’s final, recently translated texts ‘Note sur M. Bergson et la Philosophie Bergsonienne’ (1914) and ‘Note Conjointe sur M Descartes et la Philosophie Cartésienne’ (1924) will be prioritized. Finally, this study considers distinct methodological differences within the field of theology regarding the status of history and its capacity to speak – and how – to contemporary theological concerns.
The evolution of Portuguese trade unionism: Political economies and power resources
Authors: Dias Hugo 
Published: May 2021

AbstractThe present work set out to study the evolution of Portuguese trade unionism, by articulating the different cycles of economic growth of the country and their respective political economies with the impacts on the development of its power resources. The study is divided into four parts: first, it gives an overview of the economy, labour relations and trade unionism; the second part analyses the process of asymmetric European integration and the implementation of the austerity policies (2011–2015); the third part studies the political cycle between 2015 and 2019, the so‐calledContraption; finally, some preliminary considerations are advanced.
Knowledge and Attitude of Community Nurses on Pressure Injury Prevention: A Cross‐sectional Study in an Indonesian City
Authors: Sari Sheizi Prista , Everink Irma HJ , Amir Yufitriana , Lohrmann Christa , Halfens Ruud JG , Moore Zena , Beeckman Dimitri , Schols Jos MGA 
Published: May 2021

AbstractThe objectives of this study were to examine the knowledge and attitude of Indonesian community nurses regarding Pressure Injury (PI) prevention. A cross‐sectional design was used and included the community nurses permanently working in the Public Health Center (Puskemas) in Bandung, West Java Indonesia. Knowledge was measured using the Pressure Ulcer Knowledge Assessment Tool (PUKAT 2.0). Attitudes were measured using a predesigned instrument which included 11 statements on a five point Likert scale. All data were collected using paper‐based questionnaires. The response rate was 100%. Respondents (n = 235) consisted of 80 community nursing program coordinators (34.0%) and 155 community nurses (66.0%). Regarding knowledge, the percentage of correct answers in the total group of community nurses on the PUKAT 2.0 was 30.7%. The theme “Prevention” had the lowest percentage of correct answers (20.8%). Community nurses who had additional PI or wound care training had a higher knowledge score compared with community nurses who did not have additional PI training (33.7% vs 30.3%; Z = −1.995; P = 0.046). The median attitude score was 44 (maximum score 55; range 28–55), demonstrating a positive attitude among participants towards PI prevention. Further, the higher the education status of participants, the more positive the attitudes (H = 11.773; P = 0.003). This study shows that community nurses need to improve their basic knowledge of PI prevention. Furthermore, research should be performed to explore what community nurses need to strengthen their role in PI prevention.
Microbiological effects in patients with leg ulcers and diabetic foot treated with Lucilia sericata larvae
Authors: Szczepanowski Zbigniew , Grabarek Beniamin O. , Boroń Dariusz , Tukiendorf Andrzej , Kulik‐Parobczy Iwona , Miszczyk Leszek 
Published: May 2021

AbstractLucilia sericata bottle fly worms can be used to heal infected, chronic, or necrotic wounds, including those associated with ulceration and diabetic foot. The study aimed to evaluate changes in the microflora in patients treated with L sericata larvae due to leg ulcers and diabetic foot. One hundred twenty‐nine patients diagnosed with lower limb ulceration and diabetic foot were enrolled in the study, of which 80 of them met the eligibility criteria for maggot debridement therapy (MDT). On the contrary, 49 unqualified patients were offered ozone therapy (22 with leg ulcers; 27 with diabetic foot). In each of these patients, a microbiological swab was performed before and after the start of therapy. The group of 80 patients was further divided into four equal groups in terms of the treated area (lower leg vs foot) and the number of larvae/cm2 (5 vs 10). Twenty‐three particular species of bacteria in the infected wound were studied microbiologically in terms of presence/absence within the wound environment before and after treatment of patients with diabetic foot and lower limb ulceration. It was noted that there was a more intensive bacterial accumulation in the feet of patients compared to legs; furthermore, this applies to almost all analysed species. Diabetes status is also a clinical factor that generates a lower chance of bacterial appearance in the wound environment. Densification of MDT larvae per wound area unit also reduced the chance of the presence of Corynebacterium species, Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus aureus MSSA, and Streptococcus coagulase negativa; however, it increased the likelihood of occurrence for Proteus mirabilis and the Proteus species. A microbiological analysis in this non‐reference study shows the efficacy of larval therapy for leg and foot ulcers. Rearrangement of the microflora within the wound has been reported as a result of the therapy.
A review of the meta‐analysis by Tingir and colleagues (2017) on the effects of mobile devices on learning
Authors: Bissonnette Steve , Boyer Christian 
Published: May 2021

AbstractTingir et al. (2017) concluded from their meta‐analysis that the subject areas taught through mobile devices had significantly higher achievement scores (d = 0.48) than the ones taught with traditional teaching methods. Given the relatively high positive effect of mobile devices on student achievement, we carefully analysed the selected research in this meta‐analysis. We reviewed Tingir et al.’s (2017) meta‐analysis based on analysis of the methodology of the selected research, while drawing on the work of Slavin (2003), Cheung and Slavin (2016), and Sung et al. (2019). Twelve of the 14 (86%) studies included in the meta‐analysis done by Tingir and his team (2017) present such major methodological flaws that they should not have been included. Our analysis leads us to believe that the conclusion of Tingir et al. (2017) is not justified. It is recognized that duration of experiment is negatively correlated with effect size: the shorter the duration, the higher the effect (Burston, 2015; Slavin & Lake, 2009). Although demanding more effort, the field of education must raise the bar if it is to have knowledge of acceptable value.
Circ_0023404 sponges miR‐136 to induce HK‐2 cells injury triggered by hypoxia/reoxygenation via up‐regulating IL‐6R
Authors: Xu Yong , Li Xiang , Li Hailun , Zhong Lili , Lin Yongtao , Xie Juan , Zheng Donghui 
Published: May 2021

AbstractThe significance of circular RNAs (circRNAs) is reported in various kidney diseases including acute kidney injury (AKI). Specific circRNAs have the capacity to function as novel indicators of AKI. Circ_0023404 exhibits an important role in several diseases. Nevertheless, the detailed biological role of circ_0023404 in AKI remains poorly known. The present study aimed to investigate the effect of circ_0023404 on renal ischaemia/reperfusion (I/R) injury in vitro. Here, we evaluated the function of circ_0023404 in HK‐2 cells in response to hypoxia/reoxygenation (H/R). We established a cell AKI model induced by H/R in HK‐2 cells. We found circ_0023404 was significantly increased in AKI. Then, we found loss of circ_0023404 increased cell growth, repressed apoptosis, reduced inflammatory factors secretion and oxidative stress generation in vitro. Besides, circ_0023404 sponged miR‐136. miR‐136 overturned the effects of circ_0023404 on HK‐2 cell injury. We assumed IL‐6 receptor (IL‐6R) as a target of miR‐136 and IL‐6R was activated by circ_0023404 via sponging miR‐136. In conclusion, we revealed circ_0023404 contributed to HK‐2 cells injury stimulated by H/R via sponging miR‐136 and activating IL‐6R.
MiR‐664‐3p suppresses osteoblast differentiation and impairs bone formation via targeting Smad4 and Osterix
Authors: Xu Yuexin , Jin Yucui , Hong Fangling , Ma Yunfei , Yang Jiashu , Tang Yuting , Zhu Zhu , Wu Jiahui , Bao Qianyi , Li Lingyun , Yao Bing , Li Dong , Ma Changyan 
Published: May 2021

AbstractOsteoporosis is a metabolic disorder characterized by low bone mass and deteriorated microarchitecture, with an increased risk of fracture. Some miRNAs have been confirmed as potential modulators of osteoblast differentiation to maintain bone mass. Our miRNA sequencing results showed that miR‐664‐3p was significantly down‐regulated during the osteogenic differentiation of the preosteoblast MC3T3‐E1 cells. However, whether miR‐664‐3p has an impact on bone homeostasis remains unknown. In this study, we identified overexpression of miR‐664‐3p inhibited the osteoblast activity and matrix mineralization in vitro. Osteoblastic miR‐664‐3p transgenic mice exhibited reduced bone mass due to suppressed osteoblast function. Target prediction analysis and experimental validation confirmed Smad4 and Osterix (Osx) are the direct targets of miR‐664‐3p. Furthermore, specific inhibition of miR‐664‐3p by subperiosteal injection with miR‐664‐3p antagomir protected against ovariectomy‐induced bone loss. In addition, miR‐664‐3p expression was markedly higher in the serum from patients with osteoporosis compared to that from normal subjects. Taken together, this study revealed that miR‐664‐3p suppressed osteogenesis and bone formation via targeting Smad4 and Osx. It also highlights the potential of miR‐664‐3p as a novel diagnostic and therapeutic target for osteoporotic patients.
Transforming growth factor‐β1 signalling triggers vascular endothelial growth factor resistance and monocyte dysfunction in type 2 diabetes mellitus
Authors: Makowski Lena‐Maria , Leffers Merle , Waltenberger Johannes , Pardali Evangelia 
Published: May 2021

AbstractType 2 diabetes mellitus (T2DM) leads to monocyte dysfunction associated with atherogenesis and defective arteriogenesis. Transforming growth factor (TGF)‐β1, placenta growth factor (PlGF)‐1 and vascular endothelial growth factor (VEGF)A play important roles in atherogenesis and arteriogenesis. VEGF‐receptor (VEGFR)‐mediated monocyte migration is inhibited in T2DM (VEGFA resistance), while TGF‐β1‐induced monocyte migration is fully functional. Therefore, we hypothesize that TGF‐β antagonises the VEGFA responses in human monocytes. We demonstrate that monocytes from T2DM patients have an increased migratory response towards low concentrations of TGF‐β1, while PlGF‐1/VEGFA responses are mitigated. Mechanistically, this is due to increased expression of type II TGF‐β receptor in monocytes under high‐glucose conditions and increased expression of soluble (s)VEGFR1, which is known to interfere with VEGFA signalling. VEGFA resistance in monocytes from T2DM patients can be rescued by either experimental down‐regulation of TGF‐β receptor expression in vitro or by functional blocking of TGF‐β signalling using either a TGF‐β receptor kinase inhibitor or a TGF‐β neutralizing antibody. Our data demonstrate that both T2DM and high‐glucose potentiate the TGF‐β pathway. TGF‐β signalling impairs VEGFR‐mediated responses in T2DM monocytes and in this way contributes to mononuclear cell dysfunction, provide novel insights into T2DM vascular dysfunction.
Effect of lncRNA‐ATB/miR‐651‐3p/Yin Yang 1 pathway on trophoblast‐endothelial cell interaction networks
Authors: Yin Yangxue , Zhang Jiashuo , Yu Hongbiao , Liu Min , Zheng Xuelian , Zhou Rong 
Published: May 2021

AbstractOur previous studies have confirmed that lncRNA‐ATB may be involved in the pathogenesis of preeclampsia, however, it is uncertain whether lncRNA‐ATB influence the interaction between trophoblast and endothelial cells, which is crucial to the uterine spiral artery remodelling. Scratch wound healing and transwell invasion assay were conducted to test the migration and invasion of trophoblast cells. Co‐culture model was used to simulate the physiological environment in vivo. The expression levels of lncRNA‐ATB were analyzed in placenta tissues from healthy pregnant women and preeclampsia patients. Subsequently, the binding site of lncRNA‐ATB and miR‐651‐3p was verified using dual‐luciferase reporter assay, and the rescue experiment was used to study the effects of these two on the biological function. The direct effects of miR‐651‐3p and Yin Yang 1 (YY1) were verified using similar methods. LncRNA‐ATB was found to be down‐regulated in the placenta of preeclampsia patients. LncRNA‐ATB knockdown decreased trophoblast migration, invasion and colocalisation with human umbilical vein endothelial cells. MiR‐651‐3p was a direct target of lncRNA‐ATB and they had opposite effects. Moreover, the expression of lncRNA‐ATB and miR‐651‐3p in placental tissues was negatively correlated. MiR‐651‐3p has been confirmed to directly target the 3′ untranslated region of YY1. The inhibitory effects of YY1 low expression on biological function was rescued by miR‐651‐3p depletion. Western blot analysis showed that lncRNA‐ATB could regulate YY1 expression by sponging miR‐651‐3p. LncRNA‐ATB functioned as a competitive endogenous RNA of miR‐651‐3p to regulate YY1 on progress of spiral artery remodelling.
Liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes mellitus
Authors: Huang Jinya , Li Rumei , Liu Naijia , Yi Na , Zheng Hangping , Zhang Qi , Zhou Lianying , Zhou Linuo , Hu Renming , Lu Bin 
Published: May 2021

AbstractAims/IntroductionNon‐alcoholic fatty liver disease and type 2 diabetes mellitus are closely related, and often occur simultaneously in patients. Type 2 diabetes increases the risk of diabetic peripheral neuropathy, resulting in intolerable pain and extremity amputation that reduces the quality of life. However, the role of non‐alcoholic fatty liver disease in the pathogenesis of diabetic peripheral neuropathy remains unclear. Thus, we evaluated the correlation of liver fibrosis and steatosis, which are representative histological morphologies of non‐alcoholic fatty liver disease, with diabetic peripheral neuropathy in type 2 diabetes patients.Materials and MethodsFive hundred twenty individuals with type 2 diabetes were recruited. All the patients were detected nerve conduction study for diabetic peripheral neuropathy and fibro touch for liver steatosis and fibrosis. Correlation of DPN with liver steatosis and fibrosis were analysed with binary logistic analysis.ResultsAmong the 520 patients, the prevalence of liver steatosis, fibrosis and diabetic peripheral neuropathy was 63.0% (n = 328), 18.1% (n = 94) and 52.1% (n = 271), respectively. The prevalence of diabetic peripheral neuropathy was significantly elevated in patients with liver steatosis (55.7 vs 44.9%, P = 0.03) and fibrosis (61.5 vs 50%, P = 0.04), and it increased as liver stiffness measurement increased. Additionally, both hepatic steatosis (odds ratio 1.48, 95% confidence interval 1.04–2.11, P = 0.03) and fibrosis (odds ratio 1.60, 95% confidence interval 1.02–2.51, P = 0.04) were correlated with diabetic peripheral neuropathy. After adjusting for age, sex, weight, height, body mass index, waist hip ratio, duration of type 2 diabetes, blood glucose, homeostatic model assessment of insulin resistance, blood pressure, serum lipid, liver enzyme, urea, uric acid, creatinine and inflammatory factors, liver fibrosis remained associated with diabetic peripheral neuropathy (odds ratio 2.24, 95% confidence interval 1.11–4.53, P = 0.02).ConclusionsThe prevalence of diabetic peripheral neuropathy was elevated in patients with liver steatosis and fibrosis. Liver fibrosis was also independently associated with an increased risk of diabetic peripheral neuropathy.
iGlarLixi reduces residual hyperglycemia in Japanese patients with type 2 diabetes uncontrolled on basal insulin: A post‐hoc analysis of the LixiLan JP‐L trial
Authors: Yabe Daisuke , Iizuka Katsumi , Baxter Mike , Watanabe Daisuke , Kaneto Hideaki 
Published: May 2021

AbstractIntroductionTreatments for type 2 diabetes targeting baseline glucose levels but not postprandial glucose can result in normalized fasting blood glucose but suboptimal overall glycemic control (high glycated hemoglobin): residual hyperglycemia. In Japanese patients with type 2 diabetes the predominant pathophysiology is a lower insulin secretory capacity, and residual hyperglycemia is common with basal insulin treatment. Single‐injection, fixed‐ratio combinations of glucagon‐like peptide‐1 receptor agonists and basal insulin have been developed. iGlarLixi (insulin glargine 100 units/mL [iGlar]: lixisenatide ratio of 1 unit:1 µg) is for specific use in Japan. Post‐hoc analysis of the LixiLan JP‐L trial (NCT02752412) compared the effect of iGlarLixi with iGlar on this specific subpopulation with residual hyperglycemia.Materials and MethodsOutcomes at week 26 (based on the last observation carried forward) were assessed in patients in the modified intent‐to‐treat population with baseline residual hyperglycemia.ResultsOverall, 83 (32.5%) patients in the iGlarLixi group and 79 (30.7%) patients in the iGlar group had baseline residual hyperglycemia. The proportion of patients with residual hyperglycemia at week 26 decreased to 15.7% in the iGlarLixi group, and increased to 36.9% in the iGlar group. Patients in the iGlarLixi group had significantly greater reductions in glycated hemoglobin compared with the iGlar group (−0.72% difference between groups; P < 0.0001).ConclusionsNew data from this post‐hoc analysis of the JP‐L trial show that treatment with the fixed‐ratio combination iGlarLixi reduced the proportion of Japanese patients with residual hyperglycemia from baseline to week 26 and significantly reduced glycated hemoglobin vs similar doses of iGlar alone.