bluuebunny/crossref_metadata_2025_split huggingface dataset:
Übergabe von Verletzten an der Schnittstelle Rettungsdienst – Notaufnahme
Authors: Roessler Markus , Spering Christopher 
Published: September 2021

ZusammenfassungDie Versorgung eines Verletzten in einer zentralen Notfallaufnahme bzw. eines Schwerverletzten im Schockraum stellt hohe Anforderungen an Organisation, Personal und Material, da Patienten aller Altersklassen und mit allen denkbaren Verletzungen mit potenziellen oder manifesten Störungen der Vitalfunktionen zur Aufnahme kommen. Die multiprofessionellen Teams von Rettungsdienst und Notaufnahme müssen daher gut ausgebildet sein und idealerweise gemeinsam ihre Handlungsabläufe trainieren. Nur wenn jeder bei der Übergabe eines Patienten Anwesende weiß, wie die Abläufe sind und welche Aufgaben die Teammitglieder wahrnehmen müssen, wird in kritischen Situationen ein Arbeiten Hand in Hand möglich sein. Sind all diese Voraussetzungen erfüllt, ist ein Schockraumteam in der Lage, bei schwerstkranken und -verletzten Patienten die Vitalfunktionen zu stabilisieren, korrekte Diagnosen zu stellen und damit wesentlichen Einfluss auf das Überleben und den weiteren Krankheitsverlauf des
Patienten zu nehmen.
Outcomes of Repair of Total Graft Detachment following Descemetʼs Membrane Endothelial Keratoplasty
Authors: Adler Avital , Rozanes Eliane , Ciechanowski Peter , Nahum Yoav , Graffi Shmuel , Elbaz Uri , Bahar Irit , Livny Eitan 
Published: September 2021

Abstract
Objective To present the outcomes of attempts to salvage total graft detachment following Descemetʼs membrane endothelial keratoplasty (DMEK).
Methods A search of the electronic medical records of two tertiary medical centers for all patients who underwent DMEK yielded six cases of postoperative total graft detachment (2.54%). Graft salvage was attempted in all cases using repeated intracameral graft staining, unfolding, and reattachment to the stroma under 20% hexafluoride gas.
Results In all cases, a free-floating totally detached graft was identified in the anterior chamber shortly after surgery. Salvage surgery resulted in a central, well-oriented, and fully attached graft. In three cases, the primary graft failed, and in two, the corneas cleared at first but failed after 2 months and 1 year respectively. In one case, the cornea remained clear during 1 year of follow-up but had a very low endothelial cell density.
Conclusion Reattachment of fully detached DMEK graft is technically possible, but graft manipulation during the primary and secondary operations is likely to damage the endothelial cells, resulting in primary or early graft failure. If graft salvage is attempted, the probability of primary or early graft failure should be discussed with the patient, and expectations should be tempered accordingly.
Bedeutung der Einfluss- und protektiven Faktoren bei der psychischen Belastung von medizinischem Personal in Zeiten der SARS-CoV-2-Pandemie
Authors: Thielmann Beatrice , Schumann Heiko , Ulbrich Ruben , Böckelmann Irina 
Published: September 2021

ZusammenfassungDie SARS-CoV-2-Pandemie hat nicht nur die Gesellschaft, sondern auch das Gesundheitssystem vor Herausforderungen gestellt. Bei medizinischem Fachpersonal ist eine psychische Belastung
reichlich vorhanden. Die vorliegende Arbeit reflektiert die Bedeutung von Einfluss- und schützenden Faktoren im Umgang mit der psychischen Belastung bei medizinischem Personal insgesamt. Vor
diesem Hintergrund ist es möglich, neue Erkenntnisse mit Blick auf das Rettungsdienstpersonal abzuleiten, in Zeiten der SARS-CoV-2-Pandemie.Dabei kristallisieren sich belastende Faktoren, wie erhöhte Arbeitsanforderungen und gesellschaftliche Erwartungen an das Gesundheitssystem, das Risiko einer Infektion und die damit
verbundene Sorge um Infektion der eigenen Angehörigen, heraus. Rollenkonflikte zwischen beruflicher Verantwortung, Angst und Schuldgefühlen bestehen. Die rechtzeitige Gegensteuerung gegen
Belastungen ist ein effektiver Weg, um langfristige negative Beanspruchungsfolgen bei medizinischem Personal zu vermeiden.Ein gemeinsames Handeln von Arbeitgebern, Führungskräften, Angestellten und Betriebsärzten im präventiven Kontext erscheint insbesondere während der Pandemie wichtig. Es werden Hinweise zum
Umgang mit psychischen Belastungen für medizinisches Personal unterschiedlicher Verantwortungsebenen dargestellt und Präventionsansätze abgeleitet.
Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species
Authors: Scotti Francesca , Mou Linru , Huang Chen , Booker Anthony , Weckerle Caroline , Maake Caroline , Heinrich Michael 
Published: September 2021

AbstractEfficient wound treatment that addresses associated infections and inflammation remains one of the big unmet needs, especially in low- and middle-income countries. One strategy for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. A unique novel opportunity could be photo-enhanced wound treatment with a combination of light-sensitive plant preparations and local exposure to daylight. Data mining strategies using existing resources offer an excellent basis for developing such an approach with many potential plant candidates. In the present analysis, we researched the 535 botanical drugs included in the Chinese pharmacopeia and identified 183 medicinal plant species, 82 for treating open wounds caused by trauma and 101 for inflammatory skin conditions. After further screening for reports on the presence of known photoactive compounds, we determined a core group of 10 scientifically
lesser-known botanical species that may potentially be developed into more widely used topical preparations for photodynamic treatment of infected wounds. Our predictive approach may contribute to developing a more evidence-based use of herbal medicines.
Transition Metal Complex Catalyzed Photo- and Electrochemical (De)hydrogenations Involving C=O and C=N Bonds
Authors: Siewert Inke , Fokin Igor , Kuessner Kai-Thorben 
Published: September 2021

AbstractHerein, we summarize the photo- and electrochemical protocols for dehydrogenation and hydrogenations involving carbonyl and imine functions. The three basic principles that have been explored to interconvert such moieties with transition metal complexes are discussed in detail and the substrate scope is evaluated. Furthermore, we describe some general thermodynamic and kinetic aspects of such electro- and photochemically driven reactions.1	Introduction2	Dehydrogenation Reactions2.1	Electrochemical Dehydrogenations Using High-Valent Metal Species2.2	Electrochemical Dehydrogenations Involving Metal Hydride species2.3	Photochemically Driven Dehydrogenation3	Hydrogenation Reactions3.1	Electrochemical Protocols3.2	Photochemical Protocols4	Conclusion5	Abbreviations
Synthesis of Aryl Dithiocarbamates from Tetramethylthiuram Monosulfide (TMTM) and Aryl Boronic Acids: Copper-Catalyzed Construction of C(sp2)–S Bonds
Authors: Xia Xu-Ling , Zhu Qi-Long , Dong Zhi-Bing , Chen Jin-Quan , Shi Zhen 
Published: September 2021

AbstractA highly efficient method for the synthesis of S-aryl dithiocarbamates is reported. By using tetramethylthiuram monosulfide (TMTM) and aryl boronic acids as starting materials, C(sp2)–S bond-forming reactions proceed smoothly to give the desired aryl dithiocarbamates in good to excellent yields. The methodology features a simple procedure, broad functional group tolerance and excellent yields, whilst showing potential synthetic value for the preparation of a diverse range of biologically and pharmaceutically active compounds.
Researcher Perceptions of a Self-Service Online Portal to Facilitate Volunteer Recruitment into Clinical Trials
Authors: Emani Srinivas , Hsieh Yichuan Grace , Estey Greg , Parker Holly M. , Zhang Xiaofeng , Donelan Karen , Chung Jeanhee A. 
Published: September 2021

Abstract
Background Recruitment of volunteers is a major challenge for clinical trials. There has been increasing development and use of Internet-based portals in recruitment for clinical research. There has been little research on researcher use and perceptions of these portals.
Objectives This study evaluated researcher perceptions of use of Rally, an Internet-based portal for clinical trial volunteer recruitment.
Methods A cross-sectional survey was developed and implemented to understand researcher perceptions. From theoretical models of information technology use, the survey adopted items in four domains: ease of use, usefulness, facilitating conditions, and self-efficacy. The dependent variable was researchers' behavioral intention to use Rally. The survey captured characteristics of researchers such as gender, age, and role. It was implemented using the REDCap survey tool. An email invitation followed by three reminders was sent to researchers. A hierarchical regression model was applied to assess predictors of behavioral intention.
Results The survey response rate was 35.6% (152 surveys received from 427 contacted researchers). In the hierarchical regression model, facilitating conditions and self-efficacy predicted behavioral intention (F (4,94) = 6.478; p <0.001). The model explained 21.6% of the variance in behavioral intention (R-square change = 21.3%, p <0.001).
Conclusion Facilitating conditions and self-efficacy predicted researchers' behavioral intention to use Rally for volunteer recruitment into clinical trials. Future research should document best practices and strategies for enhancing researcher use of online portals for volunteer recruitment.
A Normative Observational Study of the Relationship of the Philtral Ridges to the Columellar Base in South-Indian Population and its Significance on Cleft Lip Repair
Authors: Fernandes Deyonna Deepthi , Hussain Syed Altaf 
Published: September 2021

Abstract
Introduction The philtral ridges form a prominent visual landmark in the upper lip. An aesthetically pleasing cleft lip repair should restore this preferably without any scars cutting across it. Although there are several scientific publications on morphology of this structure and its variations, very few studies on the Indian population have been published.
Aim To study the morphology of the philtral ridges and their relationship to the columellar base in normal Indian children and its significance in cleft lip repair.
Methods 115 normal healthy children from southern India aged between one and 12 years were studied based on direct observation of the relationship of the superior end of the philtral ridge to the columellar base and nasal sill. In type A, the philtral ridge terminates at the nasal sill just lateral to the columellar base, and in type B, it either reaches or fades before reaching the columellar base. All observations were performed by the first author by examining standardized two-dimensional (2D) photographs of the upper lip-nose complex.
Results In this study, 74% of the subjects had the philtral column extending lateral to the columellar base.
Conclusion These finding assume a significance since, in a substantial proportion of the studied population, techniques of cleft lip repair such as the rotation advancement method, place a scar that crosses the upper third of the philtral ridge which may be undesirable.
Ruling out Pulmonary Embolism in Patients with (Suspected) COVID-19—A Prospective Cohort Study
Authors: Stals Milou A.M. , Kaptein Fleur H.J. , Bemelmans Remy H.H. , van Bemmel Thomas , Boukema Inge C. , Braeken Dionne C.W. , Braken Sander J.E. , Bresser Carlinda , Cate Hugo ten , Deenstra Duco D. , Dooren Yordi P.A. van , Faber Laura M. , Grootenboers Marco J.J.H. , Haan Lianne R. de , Haazer Carolien , Sol Antonio Iglesias del , Kelliher Sarah , Koster Ted , Kroft Lucia J.M. , Meijer Rick I. , Pals Fleur , van Thiel Eric R.E. , Westerweel Peter E. , Wolde Marije ten , Klok Frederikus A. , Huisman Menno V. ,   on behalf of the Dutch COVID & Thrombosis Coalition (DCTC)
Published: September 2021

Abstract
Background Diagnostic strategies for suspected pulmonary embolism (PE) have not been prospectively evaluated in COVID-19 patients.
Methods Prospective, multicenter, outcome study in 707 patients with both (suspected) COVID-19 and suspected PE in 14 hospitals. Patients on chronic anticoagulant therapy were excluded. Informed consent was obtained by opt-out approach. Patients were managed by validated diagnostic strategies for suspected PE. We evaluated the safety (3-month failure rate) and efficiency (number of computed tomography pulmonary angiographies [CTPAs] avoided) of the applied strategies.
Results Overall PE prevalence was 28%. YEARS was applied in 36%, Wells rule in 4.2%, and “CTPA only” in 52%; 7.4% was not tested because of hemodynamic or respiratory instability. Within YEARS, PE was considered excluded without CTPA in 29%, of which one patient developed nonfatal PE during follow-up (failure rate 1.4%, 95% CI 0.04–7.8). One-hundred seventeen patients (46%) managed according to YEARS had a negative CTPA, of whom 10 were diagnosed with nonfatal venous thromboembolism (VTE) during follow-up (failure rate 8.8%, 95% CI 4.3–16). In patients managed by CTPA only, 66% had an initial negative CTPA, of whom eight patients were diagnosed with a nonfatal VTE during follow-up (failure rate 3.6%, 95% CI 1.6–7.0).
Conclusion Our results underline the applicability of YEARS in (suspected) COVID-19 patients with suspected PE. CTPA could be avoided in 29% of patients managed by YEARS, with a low failure rate. The failure rate after a negative CTPA, used as a sole test or within YEARS, was non-negligible and reflects the high thrombotic risk in these patients, warranting ongoing vigilance.
Apixaban and Dalteparin for the Treatment of Venous Thromboembolism in Patients with Different Sites of Cancer
Authors: Agnelli Giancarlo , Muñoz Andrés , Franco Laura , Mahé Isabelle , Brenner Benjamin , Connors Jean M. , Gussoni Gualberto , Hamulyak Eva N. , Lambert Catherine , Suero Maria Rosales , Bauersachs Rupert , Torbicki Adam , Becattini Cecilia 
Published: September 2021

AbstractEfficacy and safety of anticoagulant treatment for venous thromboembolism (VTE) may vary in patients with different cancer sites. We evaluated the rates of VTE recurrence and major bleeding and the relative efficacy and safety of 6-month treatment with oral apixaban or subcutaneous dalteparin in patients with different cancer sites randomized in the Caravaggio study. Primary cancer was located at gastrointestinal sites in 375 patients (32.5%), lung in 200 (17.3%), breast in 155 (13.4%), genitourinary sites in 139 (12%), gynecological sites in 119 (10.3%), and was hematological in 85 patients (7.4%). Rates of VTE recurrence were 10.9% in patients with gynecological, 8.8% with gastrointestinal, 6.5% with genitourinary, and 5.5% with lung cancer with lower rates in the other sites of cancer. Rates of major bleeding were 7.2% in patients with genitourinary and 4.8% with gastrointestinal cancer, with lower rates in patients with other sites of cancer. The observed absolute risk difference in VTE recurrence in favor of apixaban was 11.9% in patients with gynecological, 5.5% with lung, 3.7% with genitourinary cancer, and 0.6% with gastrointestinal cancer. None of the risk differences was statistically significant. The rates of major bleeding in patients treated with apixaban or dalteparin was similar across patients with different cancer sites. In conclusion, recurrences appear to be more common in patients with gastrointestinal and gynecological cancer and major bleedings in patients with genitourinary and gastrointestinal cancer. Oral apixaban is a valid oral alternative to subcutaneous dalteparin for the treatment of a large spectrum of patients with cancer-associated VTE.
An Analysis of Electronic Health Record Work to Manage Asynchronous Clinical Messages among Breast Cancer Care Teams
Authors: Steitz Bryan D. , Unertl Kim M. , Levy Mia A. 
Published: September 2021

Abstract
Objective Asynchronous messaging is an integral aspect of communication in clinical settings, but imposes additional work and potentially leads to inefficiency. The goal of this study was to describe the time spent using the electronic health record (EHR) to manage asynchronous communication to support breast cancer care coordination.
Methods We analyzed 3 years of audit logs and secure messaging logs from the EHR for care team members involved in breast cancer care at Vanderbilt University Medical Center. To evaluate trends in EHR use, we combined log data into sequences of events that occurred within 15 minutes of any other event by the same employee about the same patient.
Results Our cohort of 9,761 patients were the subject of 430,857 message threads by 7,194 employees over a 3-year period. Breast cancer care team members performed messaging actions in 37.5% of all EHR sessions, averaging 29.8 (standard deviation [SD] = 23.5) messaging sessions per day. Messaging sessions lasted an average of 1.1 (95% confidence interval: 0.99–1.24) minutes longer than nonmessaging sessions. On days when the cancer providers did not otherwise have clinical responsibilities, they still performed messaging actions in an average of 15 (SD = 11.9) sessions per day.
Conclusion At our institution, clinical messaging occurred in 35% of all EHR sessions. Clinical messaging, sometimes viewed as a supporting task of clinical work, is important to delivering and coordinating care across roles. Measuring the electronic work of asynchronous communication among care team members affords the opportunity to systematically identify opportunities to improve employee workload.
Genioplasty and Mandibular Implants
Authors: Shokri Tom , Rosi-Schumacher Mattie , Petrauskas Laura , Chan David , Ducic Yadranko 
Published: September 2021

AbstractGenioplasty is a useful technique employed for both aesthetic and, in the case of obstructive sleep apnea, functional purposes. Mandibular implants similarly represent a powerful tool in the facial surgeons armamentarium. Herein, we review relevant anatomy, patient evaluation, and various techniques employing both alloplastic augmentation and osseous modification of the mandible.
Postoperative Pain and Opioid Use after Facial Feminization Surgery
Authors: Chou David W. , Block-Wheeler Nikolas R. , Kshirsagar Rijul , Brandstetter Kathleyn , Kleinberger Andrew , Shih Charles 
Published: September 2021

AbstractThe objective of this study is to characterize surgical pain after facial feminization surgery (FFS) and delineate postoperative opioid usage. It is a retrospective cohort study. It was performed in a multicenter integrated health care system. Electronic medical records were reviewed for patient demographic characteristics, medical history, pain medication prescriptions, and responses to a postoperative pain survey. Student's t-test and the Mann–Whitney U-test were used for bivariate analysis. Fisher's exact tests were used for categorical data. Seventy-four patients who underwent FFS were included. The mean (standard deviation) reported “average” postoperative pain score was 4.3 (2.3) out of 10. A total of 58% of patients reported pain lasting 5 or fewer days after surgery. The severity and duration of postoperative pain was similar between patients who underwent partial-FFS or full-FFS. A total of 68% of patients required fewer than 15 opioid tablets. There were no significant differences in the quantity of opioids prescribed or used between patients who underwent partial-FFS or full-FFS. Older age and premorbid mood disorder did not correlate with greater severity/duration of pain or number of opioids used after surgery. Most patients required fewer than 15 opioid tablets after surgery and experienced less than a week of postoperative pain. Patients undergoing full-FFS did not appear to experience significantly greater pain than those undergoing fewer procedures. Older age and premorbid mood disorder were not predictors of worse pain outcomes or greater opioid utilization.
A Meta-analysis of the Utility of Red Cell Distribution Width as a Biomarker to Predict Outcomes in Pediatric Illness (PROSPERO CRD42020208777)
Authors: Murphy Devin , Orgel Etan , Koek Wouter , Frei-Jones Melissa , Denton Christopher , Kamat Deepak 
Published: September 2021

AbstractRed cell distribution width (RDW) is an average of the variation in red blood cell (RBC) sizes reported on a complete blood count. An elevated RDW indicates a pathological process that is affecting erythropoiesis. Studies showed that as the severity of disease process increases, the RDW often increases as well. Particularly in resource-limited countries, RDW has been studied as an outcome predictor for conditions in a variety of disciplines and is offered as an adjunct monitoring tool that is cost effective, readily available, and indicative of pathological processes amenable to intervention. Particularly in pediatric critical care settings, RDW has been shown to be a reliable tool for surveillance of disease states such as sepsis. Despite the increased attention of RDW as a marker for disease outcome, collective evaluation on the utility of RDW as a marker for outcome in pediatric critical care settings is lacking. We offer a systematic review and meta-analysis of published studies to assess the ability of RDW to predict illness severity and mortality among pediatric critical care patients. Among eight studies of over 4,800 patients, we found over a two-fold increase in odds for mortality in critically ill children whose RDW was above 15.7%. This is the first systematic review of RDW being used to predict mortality in critically ill children and findings of this study may prompt early intervention in the pediatric critical care setting.
Symmetric function theory and unitary invariant ensembles
Authors: Jonnadula Bhargavi , Keating Jonathan P. , Mezzadri Francesco 
Published: September 2021

Representation theory and the theory of symmetric functions have played a central role in random matrix theory in the computation of quantities such as joint moments of traces and joint moments of characteristic polynomials of matrices drawn from the circular unitary ensemble and other circular ensembles related to the classical compact groups. The reason is that they enable the derivation of exact formulas, which then provide a route to calculating the large-matrix asymptotics of these quantities. We develop a parallel theory for the Gaussian Unitary Ensemble (GUE) of random matrices and other related unitary invariant matrix ensembles. This allows us to write down exact formulas in these cases for the joint moments of the traces and the joint moments of the characteristic polynomials in terms of appropriately defined symmetric functions. As an example of an application, for the joint moments of the traces, we derive explicit asymptotic formulas for the rate of convergence of the moments of polynomial functions of GUE matrices to those of a standard normal distribution when the matrix size tends to infinity.
Spatially resolved online particle detector using scintillators for laser-driven particle sources
Authors: Hesse M. , Ebert T. , Zimmer M. , Scheuren S. , Schaumann G. , Roth M. 
Published: September 2021

Laser-based particle accelerators have been an active field of research for over two decades moving from laser systems capable of one shot every hour to systems able to deliver repetition rates in the Hz regime. Based on the advancements in laser technology, the corresponding detection methods need to develop from single to multiple use with high readout speed. Here, we present an online compact tracker of particles using scintillators with nine resolvable energy levels and a spatial resolution of 3.6 × 3.6 mm2 over the whole active area. This paper describes the design and construction of the detector, which is based on pixellated scintillators embedded inside an absorber matrix. The scintillator pixels are fiberoptically coupled to a camera system for online readout and analysis. Calibration with a radioactive source and first experimental data measuring laser accelerated ions at the PHELIX laser at GSI, Darmstadt, Germany, are presented and discussed.