bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonconvulsive Status Epilepticus in Metabolic Encephalopathy in Indonesia Referral Hospital
Authors: Octaviana Fitri , Bestari Andriani P , Loho Anastasia M , Indrawati Luh A , Wiratman Winnugroho , Kurniawan Mohammad , Sugiarto Adhrie , Budikayanti Astri 
Published: April 2021

Background:
Nonconvulsive status epilepticus (NCSE) is often underdiagnosed in patients with metabolic encephalopathy (ME). The diagnosis of ME should be made specifically to recognize the underlying etiology. Delay in seizure identification and making a diagnosis of NCSE contributed to the poor outcome.

Objective:
This study aimed to find the incidence and outcome of NCSE in patients with ME.

Methods and Material:
This was an observational prospective cross-sectional study in patients with ME in emergency and critical care units in Cipto Mangunkusumo General Hospital. The diagnosis of NCSE was based on EEG using Salzburg Criteria for Nonconvulsive Status Epilepticus (SCNC). The outcome was assessed within 30 days after the NCSE diagnosis has been made.

Results:
A total of 50 patients with ME were involved in this study. NCSE was confirmed in 32 subjects (64%). The most common etiology of ME was sepsis (58%). The mortality rate in the NCSE and non-NCSE group was 40.6% vs 44.4%. Multiple aetiologies were risk factors to poor outcome in the NCSE group.

Conclusions:
The incidence of NCSE among patients with ME at our hospital was high. Despite the anti-epileptic treatment of the NCSE group, the underlying cause of ME is still the main factor that affected the outcome. Therefore, aggressive treatment of anti-epileptic drug (AED) should be very carefully considered knowing the possible side-effect that might worsen the outcome of patients with ME.
A Systematic Review and Meta-analysis of Prevalence of Epilepsy, Dementia, Headache, and Parkinson Disease in India
Authors: Dhiman Vikas , Menon Geetha R , Kaur Supreet , Mishra Amar , John Denny , Vishnu Mendu Vardhan Rao , Tiwari Rajnarayan R , Dhaliwal upinder Singh 
Published: April 2021

Background:
There are wide variations reported in the prevalence rates of common neurological disorders in India leading to huge treatment gap. There is no comprehensive systematic review reporting prevalence of common neurological conditions affecting Indians which is essential for developing and aligning health services to meet patient care.

Objectives:
The aim of this study was to perform a systematic review and meta-analysis of prevalence of epilepsy, dementia, headache, and Parkinson's disease (PD) in India from 1980 to 2019.

Methods and Materials:
We performed a bibliographic systematic search in PubMed and Google Scholar along with manual search for peer-reviewed cross-sectional studies and community-based surveys reporting prevalence of epilepsy, dementia, headache, and PD in India from January 1980 to July 2019. Meta-analysis was performed adopting a random-effects model using “Metafor” package in R.

Results:
The systematic review and meta-analysis included 50 studies [epilepsy (n = 22), dementia (n = 19), headache (n = 6), and PD (n = 3)] including a total of 179,1541 participants of which 5,890 were diagnosed with epilepsy, 1,843 with dementia, 914 with headache, and 121 were diagnosed with PD. The pooled prevalence of epilepsy was 4.7 per 1,000 population (95% CI: 3.8–5.6) with high heterogeneity (P < 0.01, I2 = 98%). The prevalence of dementia was found to be 33.7 per 1,000 population (95% CI: 19.4–49.8) (P = 0, I2 = 100%). The pooled prevalence of headache and PD were found to be 438.8 per 1,000 population (95% CI: 287.6–602.3) (P < 0.0001, I2 = 97.99%), and 0.8 per 1,000 population (95%CI: 0.4–1.3) (P < 0.01, I2 = 95%), respectively.

Conclusions:
The findings could be used for appropriate policy measures and targeted treatments for addressing these conditions.
Neural substrates of psychiatric symptoms in patients with Huntington’s Disease
Authors: Kamble Nitish , Saini Jitender , George Lija , Ratna Nikhil , Bhattacharya Amitabh , Yadav Ravi , Jain Sanjeev , Pal Pramod Kumar 
Published: April 2021

INTRODUCTION:
Numerous studies in Huntington’s disease (HD) have shown striatum as the major site of neuronal loss, but recently the presence of neurodegeneration in other regions of the brain is gaining attention. In our study, we used voxel-based morphometry and diffusion tensor imaging to identify other areas in the brain that are involved in the disease.

METHODS:
The present study is a prospective study conducted in the Departments of Neurology, Psychiatry, and Neuroimaging and Interventional Radiology (NIIR), NIMHANS, Bengaluru. The study included 20 genetically confirmed HD patients and 20 healthy controls. Magnetic resonance imaging was performed on a 3-Tesla Philips Achieva scanner with a 32-channel head coil with the acquisition of whole-brain T1-weighted and DTI.

RESULTS:
The patients (41.25 ± 10.04 years) and controls (38.27 ± 11.29 years) were age-matched (P = 0.38), and the mean age at the onset of the symptoms of the disease was 37.53 ± 10.11 years, and the expanded CAG repeat allele was 45.95 ± 7.27 (range 40–73) repeats. All patients had psychiatric symptoms at presentation such as anger outbursts, irritability, abusive behavior, apathy, low mood, crying spells, delusions, lack of initiation, and obsessive–compulsive disorder. Compared with controls, HD patients had significant atrophy of bilateral caudate nuclei, right globus pallidus, left culmen, right precuneus, hypothalamus, and right superior temporal gyrus. Fractional anisotropy was increased in bilateral cerebral white matter and thalamus with the reduction in mean diffusivity.

CONCLUSIONS:
In addition to atrophy of caudate, atrophy was also observed in globus pallidus, thalamus, hypothalamus and right superior temporal gyrus. This may explain the neuropsychiatric and cognitive symptoms observed in these patients.
Reticulocyte haemoglobin as a diagnostic marker and its response towards oral iron therapy in paediatric iron deficiency anaemia
Authors: Behera Bodhisatwa , Subhadarshini Sarmistha , Satapathy Jagat Shreya , Mohanty Niranjan , Mishra Debi Prasad , Mantri Santwana , Purohit Prasanta , Patro Manoj Kumar 
Published: April 2021

Background:
Iron deficiency anaemia (IDA) in the paediatric age group is prevalent in developing countries like India, especially in the lower socio-economic strata. Early detection and management will prevent the associated morbidity and mortality. Reticulocyte haemoglobin (Ret-Hb) is an indirect assessment of Hb content of reticulocytes by automated haematology analysers.

Aims:
The present study was aimed to evaluate the diagnostic efficacy of Ret-Hb in paediatric IDA and its prognostic efficacy by detecting early response to oral iron supplementation.

Materials and Methods:
This was an institutional prospective, cross-sectional study. Eighty-two cases of microcytic hypochromic anaemia, in the age group of 1–14 years negative for haemoglobinopathy by high-performance liquid chromatography, constituted the study group. Ret-Hb and serum ferritin (SF) values were correlated with other haematological parameters on day 0 and day 3 after oral iron supplementation and results obtained were statistically correlated.

Results:
The mean values of Hb, mean corpuscular volume, mean corpuscular Hb, red cell distribution width-CV (RDW-CV), Ret-Hb and SF were found to be 8.32 ± 1.99 g/dL, 63.44 ± 7.01 fL, 19.25 ± 3.21 pg, 19.16 ± 2.87%, 20.36 ± 3.41 pg and 8.99 ± 1.85 mcg/dL respectively. The Ret-Hb and SF levels were found to be linearly positively correlated with all parameters except RDW-CV which was negatively correlated; a stronger association was noted with the former. After oral supplementation on Day 3, only Ret-Hb showed statistically significant change, i.e., 20.36 ± 3.41 pg to 21.35 ± 3.61 pg (P < 0.001).

Conclusion:
Ret-Hb was found to be a reliable parameter not only in diagnosing IDA in children but also in detecting early response to oral iron supplementation.
Struggle Turning Back to Professional Nursing Practice in Iran
Authors: Mohammadi Nooredin , Seyedfatemi Naiemeh , Nikbakht-Nasrabadi Alireza , Mahmoudi Mokhtar 
Published: April 2021

Background:
Current nursing shortage is becoming more complicated because of turnover intention among nurses. Most of the inactive nurses in Iran after a long time for various rations Returned To Professional Nursing Practice (RTPNP). Because the RTPNP program does not exist in Iran to prepare inactive nurses returning to practice, this study aimed to explore the strategies that contribute to preparing nurses for RTPNP.

Materials and Methods:
The present study was a part of the findings of a larger grounded theory study that lasted about 9 months from April 2019 to December 2019. The data were collected through semi-structured interviews with participants after signing an informed consent form. The average interview duration was 40 minutes. The study participants were selected through purposeful sampling from both public and private hospitals affiliated to Iran University of Medical Sciences. Participants included eight nurses, two education supervisors, two matrons, and two head nurses. Interviews were verbatim transcribed and analyzed using a constant comparative analysis method.

Results:
Struggle turning back to PNP was the main category that emerged from four categories of “seeking learning resources,” “return to practice support,” “getting used to a practice,” and “building a new family life” from the data analysis process.

Conclusions:
Returners struggle to get prepared for providing PNP to clients if there is no definite process of RTPNP. Organizational support and RTPNP programs are efficient strategies and could help these returners get prepared for PNP.
Caregiving Strategies in Families of Children with Congenital Heart Disease
Authors: Dalir Zahra , Manzari Zahra-Sadat , Kareshki Hossein , Heydari Abbas 
Published: April 2021

Background:
The families of children with Congenital Heart Disease (CHD) experience challenges in taking care of their child, which may affect the whole family. Therefore, the families need to manage and organize the caregiving process for the child. In order to help families provide optimized and quality care for their child, it is important to understand how they manage caregiving challenges. This study was conducted with the aim to explore the strategies used by families for managing family caregiving for their child.

Materials and Methods:
This qualitative study was conducted on families of children with CHD referred to hospitals in Mashhad, Iran. The participants were selected using a purposive sampling method. The data were collected from among 40 eligible participants using in-depth and semi-structured interviews from November 2017 to December 2018. Conventional content analysis was used for data analysis and MAXQDA software for managing the coding process.

Results:
According to the results, effort to manage caregiving emerged as the main theme, which included the 4 categories of “monitoring the child's health conditions,” “organizing family life,” “optimizing family life,” and “establishing interaction.”

Conclusions:
The families used various strategies to manage caregiving including monitoring of the child's health conditions, organization, and optimization of family life, and effective interaction based on their knowledge, experiences, beliefs, and available sources. The results of the present study can help healthcare professionals and nurses to develop family-centered empowerment programs in order to promote families' abilities to manage family caregiving for a child with CHD.
An Analytical Cross-sectional Study to Compare Pulmonary Function and Respiratory Morbidity-Related Quality of Life between Construction Workers with Age-and Gender-Matched Controls
Authors: Chittaluru Praveen K. , Korra Raj K. , Asuri Vinay K. , Annakula Pratyusha , GMM Reddy 
Published: April 2021

Context:
Respiratory morbidity among construction workers is one of the most neglected occupational diseases, in spite of the high risk.

Aims:
The aim of this study is to compare the respiratory symptoms, pulmonary function, and respiratory morbidity-related quality of life between people working in construction sites and the age- and gender-matched controls.

Settings and Design:
It is an analytical cross-sectional study.

Methods and Material:
People working in the construction sites (mason/daily laborer) for at least 5 years and control group working in other occupations were included. People other than mason/daily laborer and people with a past history of COPD/bronchial asthma before joining the construction industry were excluded.

Statistical Analysis Used:
Pulmonary function test was done and St. George respiratory questionnaire was used to the quality of life. Unpaired t-test and Chi-square test/Fisher's exact test were used to compare numeric outcomes and categorical outcomes respectively.

Results:
We have included 120 construction workers and 120 age- and gender-matched controls. The Forced Vital Capacity (FVC) (mean difference [MD] 0.20, 95% CI 0.025–0.381, P value 0.025), FEV1 (MD 0.21, 95% CI 0.061–0.364, P value 0.006), and FEV1\FVC% predicted (MD 5.01, 95% CI 1.11–8.92, P value 0.012) were significantly lower among the construction workers. The overall SGRQ score was also significantly higher among the construction workers indicating poor overall respiratory morbidity-related quality of life (MD 12.69, 95% CI 10.59–14.80, P value <0.001).

Conclusions:
Pulmonary function and respiratory function-related quality of life are considerably poor among people working in the construction industry.
A Comparative Study on the Health Problems and Substance Abuse among the Tobacco Farmers and Non-Tobacco Farmers in Hassan District, Karnataka
Authors: Muniswamy Sundar , Maliakel Steffi F 
Published: April 2021

Background and Aims:
India ranks third in the worldwide tobacco production (2017), and it is increasing every year. Hassan is an important tobacco growing district in Karnataka with over 12,000 growers. These growers are exposed to health risks during cultivation of tobacco, pesticide exposure, long duration of work, mental stress, and nicotine toxicity – Green Tobacco Sickness (GTS) due to direct handling of green tobacco leaves.

Objectives:
To determine the prevalence of health problems associated with tobacco farming. To determine the extent of substance abuse in tobacco farmers as compared to non-tobacco farmers.

Methodology: Study design:
Cross-sectional study.

Duration:
3 months.

Sampling technique:
30 × 7 Cluster sampling technique. House-to-house survey was conducted in 30 tobacco growing villages of Hassan. Seven tobacco growers and seven non-growers were interviewed in each village. Alcohol use disorder identification test (AUDIT) & Fagerstrom nicotine dependence (FND) scale was used to assess the extent of substance abuse.

Results:
Symptoms of GTS like nausea, dizziness, poor appetite, insomnia were reported more in tobacco growers (p < 0.01). On FND assessment, 63% had moderate to high dependence. On AUDIT assessment, 55.07% growers who had drinking habit had hazardous drinking behavior. Logit function model was used to assess parameter estimate (OR) on substance abuse.

Conclusion:
Lack of knowledge regarding health effects of tobacco farming, lack of use of PPE, dust and smoke exposure during curing, intense physical and mental stress maybe some reasons for health problems in tobacco growers.
The Effectiveness of Low-Level Laser Therapy on Controlling Pain and Discomfort during Separator Placement before Fixation of Orthodontic Appliances
Authors: Muctar Sahar Abdelatif , Marouf Ali Abdelrahman , Awooda Elhadi Mohieldin 
Published: April 2021

Background:
Pain and discomfort are the most common sequel of orthodontic treatment both before and after separator placement. The aim of this study was to evaluate the effectiveness of low-level laser therapy (LLLT) on pain and discomfort control during separator placement before orthodontic fixed appliance placement.

Materials and Methods:
A single-blind, split-mouth clinical trial with a sample size of six patients (12 half mouths as cases where three positions on the buccal side of each tooth lased by the power of 1 Watt diode laser before orthodontic separator placement, while the other 12 teeth acted as control where separators were placed without laser application. Assessment of pain and discomfort was done by visual analog scale. The results of pain intensity and discomfort between the study group (EG) and the control group (CG) were compared by t-test and ANOVA, and the level of significance was set at a level at P ≤ 0.05.

Results:
The majority of the laser group experienced pain during chewing (85.70%) and most of them change their food habits (66.70%). In most of the lased cases (70%), pain intensity increased after 72 h, while among the control cases; it increased after 24 h (83.40%). There was a statistically significant difference in pain degree among the laser group at different time intervals (P = 0.05), while on the control group, statistically significant difference was found at baseline immediately after placement of orthodontic separator (P = 0.05). The majority of the patients' followed the instructions and did not take any medication to decrease pain intensity (66.70%).

Conclusion:
LLLT was effective in decreasing pain and discomfort during elastic separator placement for orthodontic patients with fixed appliances.
Mobile Applications for Chronic Pain Management
Authors: Gupta Bhavna , Ahluwalia Pallavi 
Published: April 2021

Background:
There has been considerable interest in mobile and tablet technology in the field of health care. This interest has brought the area of mobile health apps, described as providing health care and health-related services through communications devices, into-sharp focus. This study aimed to assess the status of contemporary apps targeted at chronic pain assessment and management with a particular focus on patient-centered approach, criterion for pain assessment, medication assessment, targeted system, and pain management/guidance.

Methodology:
We searched for pain apps specific for chronic pain on the App Store for iOS devices and Google Play for Android devices. Each app store was searched using terms related to “pain,” “chronic pain,” “pain scale,” and “pain management.” Various parameters such as the name of the app, availability in operating systems (iOS or Android), download cost, creation dates, date of latest update, language, type of pathology, user rating, number of downloads, reviews, type of target population, the objective of the app and target population were explored. To explore the downloaded apps, an Excel® tool was designed for data extraction.

Observations:
Two hundred and fifty-four numbers of apps were identified after excluding duplicates. Forty-seven apps were included in the study that had a rating of above 4 in Google play store for further analysis. Eight out of 47 apps only did extensive pain assessment, and pain rating score was available in 14 apps. Most of the apps targeted exercise as a primary modality of management, and provided knowledge about the disease process. Few apps were based on the patients' hospital-based management and very few apps targeted yoga, integrative therapy, and trigger point as the primary modalities of management. 75% of apps targeted general pain, and only 25% were specific to an organ system. Majority of the apps were neither designed nor edited by licensed health-care providers, and there was little direct involvement by health-care professionals.

Conclusion:
The use of mobile devices can offer many advantages and opportunities for enhancing medical care. At present, due to the lack of evidence supporting their use, caution should be taken in the use of smartphones apps. These applications should also be assessed and regularly analyzed, and integrated with pain assessment and pain management and incorporate various integrative therapies based on available recommendations.
Molecular docking studies and ADME-Tox prediction of phytocompounds from Merremia peltata as a potential anti-alopecia treatment
Authors: Abdurrahman Syawal , Ruslin Ruslin , Hasanah Aliya Nur , Mustarichie Resmi 
Published: April 2021

ABSTRACT
Alopecia is a condition in which some or all of the hair from the scalp is lost. One recent preventative measure is the inhibition of the enzyme 5-α-reductase. Inhibition of the enzyme 5-α-reductase converts circulating testosterone to its more potent metabolite, dihydrotestosterone. Ethnobotically, Merremia peltata is used as a baldness medicine by utilising compounds contained within the leaves. This research aimed to test activity of 18 known compounds contained within M. peltata) as anti-alopecia. Activity was based on their interaction with the androgen receptor (PDB code 4K7a) using molecular docking and ADME-Tox prediction. The stages of research performed were: preparation of androgen protein structure databases; preparation and optimization of three-dimensional structures of compounds using ChemDraw 8.0; molecular docking to the androgen receptor protein using Autodock 1.5.6.; and ADME-Tox prediction using the pkCSM tool. The following test compounds had strong bond energies (ΔG): compound 16 (olean-12-en-3beta-ol, cinnamate)-7.71 kcal/mol, compound 17 (alpha-amyrine)-6.34 kcal/mol, and Finasteride-6.03 kcal/mol. Interestingly, the ΔG of compound 16 (olean-12-en-3beta-ol, cinnamate) is better than of minoxidil (-4.8 kcal/mol) and also to gold-standard treatment compound, finasteride. ADME-Tox prediction for compound 16 showed favorable results in several metrics such as skin permeability, absorption, and distribution. Compound 16 (olean-12-en-3beta-ol, cinnamate) is therefore a potential androgen receptor antagonist and may be beneficial in the treatment of alopecia.
Protective effect of purple corn silk extract against ultraviolet-B-induced cell damage in human keratinocyte cells
Authors: Poorahong Watcharaporn , Innalak Sukanda , Ungsurungsie Malyn , Watanapokasin Ramida 
Published: April 2021

ABSTRACT
Ultraviolet-B (UVB) could lead to inflammation and cell death induction. Purple corn silk (PCS), part of female flower of corn has multiple pharmacological properties. This investigation focused on determining the preventive effects of PCS extract on human keratinocyte HaCaT cell damage induced by UVB irradiation. Cells were irradiated with 25 mJ/cm2 UVB after pre-treated with PCS extract for 1 h. Then, the cells were then placed in culture medium followed by subsequent experiments. Cell survival was determined by MTT assay. The immunofluorescence, DCFH-DA, JC-1, and Hoeshst33342 staining assays were used to determine γ-H2AX, intracellular reactive oxygen species (ROS), membrane potential of mitochondria, and nuclear condensation, respectively. Western blot analysis was used to investigate the proteins expression. The statistically significant comparison was calculated by analysis of variance at P < 0.05. The fluorescence and protein band intensity were quantified by Image J densitometer. The results indicated cell survival was increased upon PCS extract pretreatment followed by UVB exposure. PCS extract decreased γ-H2AX expression, intracellular ROS overproduction, and nuclear condensation in cells induced by UVB. Furthermore, The PCS extract pretreatment attenuated apoptosis response through stabilized mitochondrial membrane potential, decreased apoptosis mediator proteins including Bax, Bak, cleaved-caspases, and cleaved-PARP, and increased Bcl-2 and Bcl-xL expression comparing to the UVB-treated control. This finding demonstrated that the PCS extract can reduce the deleterious effects from UVB exposure through decreased intracellular ROS, DNA damage, and apoptosis induction on HaCaT cells.