bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corrosion-resistant epoxy coating for protection of structural glued-laminated timber in high humidity conditions
Authors: Skripinets A , Saienko N , Danchenko Y , Cherkashina A 
Published: July 2021

Abstract
The article presents a solution to practical problem - the development of epoxy coating of low combustibility with corrosion-resistant properties for the protection of glued-laminated timber in conditions of high humidity. Based on the test results obtained, it was found that when using the developed epoxy polymer protective coating, the resistance of wooden beams to distilled and seawater increases by more than two orders of magnitude, ensuring the integrity of wood products and structures, protecting the ends and not causing warping of the material. In conditions of medium aggressiveness of the environment i.e. 10% H2SO4, 10% NaOH, 10% NaCl, the application of the developed epoxy polymer coating to glued-laminated timber provides their high indicators of bio- and chemical corrosion protection (water resistance, resistance to sea water and aggressive aqueous solutions). The developed protective coating has fungicidal properties, protecting structures from the appearance of blue stains, mold and wood-destroying fungi. Revealed a good correlation between the concentration of biocide and fungicidal coating properties. A comprehensive assessment showed that the developed epoxy coatings have increased biocorrosion-resistant properties and can be used as protective coatings for glued-laminated timber structures exposed to mold fungi, high temperatures and high humidity.
Improvement of technology of application of wood as a floor covering
Authors: Tsapko Y , Vasylyshyn R , Horbachova O , Bondarenko O 
Published: July 2021

Abstract
The analysis of wood flooring has been made and it has been found that the manufacture of wood flooring poses certain difficulties in ensuring resistance to destruction. Thermally modified wood is one of the promising uses of flooring. Therefore, knowledge of the physico-mechanical featutes of wood composites, their quality indicators, adhesion with organic adhesives, allows to make a choice taking into account economic indicators, duration and safety of application. Experimental studies have found out that a floor covering with an upper layer of thermally modified oak wood is less resistant to abrasion. The additional moisture effect showed a better result for the thermally modified oak samples than for the ash and oak samples. The test pieces with an upper layer of thermally modified oak are found to have the lowest measure of power. The results of the research will enable the further development of new composites of thermally modified wood and the conditions under which they are operated at different sites.
Physicochemical and physicomechanical studies of dolomite binder
Authors: Vinnichenko V I , Riazanov A N , Rakhimov R Z , Riazanov A A , Vinnychenko O V 
Published: July 2021

Abstract
To obtain dolomite cement, it is proposed to use screenings of dolomite stone and coal waste. Both physicochemical and physicomechanical studies of cement samples are carried out. It is shown that, in contrast to the existing dolomite binders, the proposed cement has the ability to harden when mixed with water.
The transportation of a particle by a vertical auger with a coaxial cylinder which rotate together around the common axis
Authors: Volina Tatiana , Pylypaka Sergiy , Pavlenko Olexandr , Klochko Oleksii , Hryshchenko Iryna 
Published: July 2021

Abstract
Differential equations of relative movement of a particle on the periphery of a vertical auger bounded by a movable coaxial cylinder are compiled. Both surfaces form a single whole and rotate around a common axis. A partial case, when the surfaces are stationary, is considered. A qualitative analysis of the obtained equations is made and on this basis, the regularities of the particle movement along the helical line – the curve of the intersection of the auger with the cylinder are found. Structural and kinematic parameters in which the particle moves upwards during sliding along the helical line, or falls downwards are found. The relative and absolute trajectories of the particle movement are constructed.
Characteristics of the limit state of the rope
Authors: Vovk P , Chaiun I 
Published: July 2021

Abstract
According to the Rules, in the calculation of ropes for strength, one characteristic is used, and it is the same regardless of the loading scheme. In the calculation method for permissible stresses, two strength characteristics are used: the yield strength or the tensile strength of the material of the part. It’s proposed the method for the theoretical determination of the characteristics of the ultimate elastic Pe
and ultimate elastic-plastic state PH
under four loading schemes, and taking into account the operational breaks of the wires (two characteristics of tension with winding on a drum with a weight in guides and with a free suspension and two when stretching a straight rope.) The ultimate elastic state is determined by the longitudinal force in the section of the rope, at which the longitudinal deformation of one of the wires reaches the yield point εT
according to the schematized wire tension diagram σ – ε. The criterion for the ultimate elastic-plastic state of the rope is the achievement of one of the wires of the ultimate uniform deformation according to the diagram σ – ε. It is assumed that on the basis of the characteristics Pe
of the stretching of the rope according to the ultimate elastic state, it is possible to construct a method for calculating the strength of the ropes, which will have advantages over the existing one. Advantage arguments:
– strength characteristics Pe
are directly related to the rope loading scheme
– the values Pe
take into account all geometric parameters of single and double lay, as well as deformation properties of wires
– characteristics Pe
allow to take into account the effect of wire breaks during the operation of the ropes.
Structural organization and operation of the structure-system
Authors: Vyrovoy Valerii , Korobko Oksana , Pishchev Oleg , Varych Hanna 
Published: July 2021

Abstract
The main factor is presentation of the building construction as open complex self-organizing system. The initial theoretical provisions on processes of self-organization of the construction both during its production period and during operational loads action period are formulated. The active elements of structure material are selected. Representation of the construction as system allows determining the conditions for safe functioning of the construction-system in the system of similar constructions.
Experimental studies of the deformation properties of concrete based on sulfate-resistant slag Portland cement as a material for hard coatings of agricultural airfields
Authors: Yanin O , Yemelianova T , Novikova S 
Published: July 2021

Abstract
The paper presents the results of experimental studies of the deformation properties of concretes based on sulfate-resistant slag Portland cement intended for hard coatings of agricultural tracks and airfields. The effect of concrete hardening conditions on the value of its relative shrinkage deformation has been studied. The role of surfactants (plasticizers) as an additional ingredient to concrete is also investigated. Based on these experimental tests, the regularities of the development of plastic deformations formed in concrete in time at a constant load are revealed. The results of the two series of experiments have made it possible to demonstrate the influence of concrete hardening conditions on the values of creep deformation that are also described and analyzed. This article analyzes the kinetics of concrete shrinkage deformations without additives, comparing the results with those for concrete with the addition of a lignosulfonate superplasticizer and also taking into account various modes of heat and humidity treatment of concrete. A comparison of the deformation properties in concrete with sulfate-resistant Portland slag cement with the deformation properties of concrete based on ordinary Portland cement is carried out. The conclusion is made about suitability of concrete with Portland slag cement for use in construction of hard coating for agricultural tracks and airfield runways.
Application of improved gradient projection method to parametric optimization of steel lattice portal frame
Authors: Yurchenko V V , Peleshko I D , Biliaiev Nikita 
Published: July 2021

Abstract
The paper has proposed a mathematical model for parametric optimization problem of the steel lattice portal frame. The design variable vector includes geometrical parameters of the structure (node coordinates), as well as cross-sectional dimensions of the structural members. The system of constraints covers load-carrying capacities constraints formulated for all design sections of structural members of the steel structure subjected to all ultimate load case combinations. The displacements constraints formulated for the specified nodes of the steel structure subjected to all serviceability load case combinations have been also included into the system of constraints. Additional requirements in the form of constraints on lower and upper values of the design variables, constraints on permissible minimal thicknesses, constraints on permissible maximum diameter-to-thickness ratio for the structural members with circle hollow sections, as well as the conditions for designing gusset-less welded joints between structural members with circle hollow sections have been also considered in the scope of the mathematical model. The method of the objective function gradient projection onto the active constraints surface with simultaneous correction of the constraints violations has been used to solve the formulated parametric optimization problem. New optimal layouts of the steel lattice portal frame by the criterion of the minimum weight, as well as minimum costs on manufacturing and erection have been presented.
A method for solving boundary value problems of mathematical theory of thick transversely isotropic plates
Authors: Zelensky A G , Demianenko A G 
Published: July 2021

Abstract
A method for solving the boundary value problems of a variant of the mathematical theory of thick transversely isotropic plates has been developed. Systems of high-order equilibrium differential equations are reduced by this method to second-order differential equations. The constructed version of the theory makes it possible to solve three-dimensional boundary value problems with any high accuracy. All components of the stress-strain state and boundary conditions are considered functions of three coordinates. They are represented by infinite mathematical series in transverse coordinate with the help of Legendre polynomials. The three-dimensional boundary-value problem is reduced to two-dimensional using the Reisner variational principle. The transverse normal and tangential stresses are displayed in such a way that the boundary conditions on the horizontal faces of the plate are exactly satisfied. Boundary value problems for semifinite transversely isotropic plates of arbitrary thickness with different boundary conditions are considered. Boundary effects are taken into account. The analysis of the stress-strain state is performed.
Characterization of Ti6Al4V powders produced by different methods for selective laser melting
Authors: Xie Bo , Fan Yazhuo , Zhao Sanchao 
Published: July 2021

Abstract
A comparative investigation was made into Ti6Al4V powders produced by electrode induction melting gas atomization (EIGA), plasma spheroidization (PS), and plasma atomization (PA) in terms of particle size distribution, shape, element distribution, microstructure, flowability and forming properties. The powders were characterized by a laser particle size and shape analyzer, a scanning electron microscopy (SEM), an energy dispersive spectrometer (EDS), an x-ray diffraction (XRD), a Hall-flow meter and SLM machine, respectively. Image analysis was used to quantitatively analyze the elongation and roundness of these Ti6Al4V powders. The results indicate that PA produces the smoothest powder with the lowest satellite sphere. The microstructure of the powders is composed of HCP-α‘ phase. The average elongation and roundness of EIGA Ti6Al4V powder is similar to those of PA Ti6Al4V powder. The flowability of the PA powder (26.23 s/50 g) is better than that of EIGA powder (32.16 s/50 g) and PS powder (35.30 s/50 g). The SLM Ti6Al4V samples produced by EIGA powder exhibit a well-balanced combination of strength (1047 MPa) and ductility (16.2%). In regard to the process of SLM, the PA and EIGA Ti6Al4V powders are more suitable than PS Ti6Al4V powder. The EIGA method is found to be the best choice among these three methods on account of cost and performance.
Mechanical and durability characteristics of sustainable coconut fibers reinforced concrete with incorporation of marble powder
Authors: Ahmad Jawad , Zaid Osama , Siddique Muhammad Shahid , Aslam Fahid , Alabduljabbar Hisham , Khedher Khaled Mohamed 
Published: July 2021

Abstract
‘Concrete needs some tensile reinforcement to enhance tensile strength and avoid unacceptable brittle nature. This study is supported out to estimate the characteristics of coconut fibers reinforced concrete with the incorporation of marble slurry. Marble waste used as binding materials in percentage of 0 to 30% in 5.0% increment by weight of cement to enhance compressive capacity while coconut fiber was used in proportion of 0.5%, 1.0%, 1.5%, 2.0%, 2.5% and 3.0% by weight of cement to enhance tensile capacity of concrete. Mechanical performance was evaluated through compressive, flexure, and split tensile strength. To assess durability characteristics of all mix, different parameters such as acid attack resistance, carbonation resistance and water absorption are examined. Experiment findings indicate that marble slurry and coconut fiber decrease the workability of fresh concrete. Furthermore, Concrete specimens’ tests indicate that marble slurry up to 20% and coconut fiber addition 2.0% tend to improve the mechanical performance of hardened Concrete. It also indicates that durability aspects such as water absorption, carbonation resistance and acid attack resistance significantly improved with the substitution of marble waste and coconut fibers. Response surface methodology (statistically models) is used to optimize combine dosage of marble slurry and coconut fiber and verified through experimental tests’.
Experimental investigation on ductility and hardness of squeeze cast Al–Si–Cu alloy using response surface methodology and excel-solver
Authors: Manikandan C , Amirthagadeswaran K S , Gunasekaran N 
Published: July 2021

Abstract
Al–Si–Cu alloy oil pump casings used in heavy automotive were produced through gravity die casting process. The customer requirement of 80–125 BHN with a ductility of 3% was not attainable with gravity die casting process. To acquire required level of ductility and hardness, heat treatment process was applied as post-processing, which increases the production cost and time. The squeeze casting technique is a process suitable to enhance the mechanical properties. A set of experiments was designed based on Box-Behnken method of Response Surface Methodology (RSM) to find the optimal parameter settings for squeeze casting process. Squeezing pressure, pouring temperature and dwelling time were considered as process parameters and a model for the process was created. Analysis of variance (ANOVA) results revealed that the model created is acceptable. Excel Solver was used to determine the optimal parameter settings to obtain maximum ductility and hardness. Confirmation tests were carried out to validate settings. The squeeze casting process, with the recommended settings, enhanced the mechanical properties and the heat treatment operation was eliminated.
Fast and powerful conditional randomization testing via distillation
Authors: Liu Molei , Katsevich Eugene , Janson Lucas , Ramdas Aaditya 
Published: July 2021

SummaryWe consider the problem of conditional independence testing: given a response $Y$ and covariates $(X,Z)$, we test the null hypothesis that $Y {\perp\!\!\!\perp} X \mid Z$. The conditional randomization test was recently proposed as a way to use distributional information about $X\mid Z$ to exactly and nonasymptotically control Type-I error using any test statistic in any dimensionality without assuming anything about $Y\mid (X,Z)$. This flexibility, in principle, allows one to derive powerful test statistics from complex prediction algorithms while maintaining statistical validity. Yet the direct use of such advanced test statistics in the conditional randomization test is prohibitively computationally expensive, especially with multiple testing, due to the requirement to recompute the test statistic many times on resampled data. We propose the distilled conditional randomization test, a novel approach to using state-of-the-art machine learning algorithms in the conditional randomization test while drastically reducing the number of times those algorithms need to be run, thereby taking advantage of their power and the conditional randomization test’s statistical guarantees without suffering the usual computational expense. In addition to distillation, we propose a number of other tricks, like screening and recycling computations, to further speed up the conditional randomization test without sacrificing its high power and exact validity. Indeed, we show in simulations that all our proposals combined lead to a test that has similar power to most powerful existing conditional randomization test implementations, but requires orders of magnitude less computation, making it a practical tool even for large datasets. We demonstrate these benefits on a breast cancer dataset by identifying biomarkers related to cancer stage.
α-Synuclein Selectively Impairs Motor Sequence Learning and Value Sensitivity: Reversal by the Adenosine A2A Receptor Antagonists
Authors: He Yan , Huang Linshan , Wang Ke , Pan Xinran , Cai Qionghui , Zhang Feiyang , Yang Jingjing , Fang Gengjing , Zhao Xinyue , You Feng , Feng Yijia , Li Yan , Chen Jiang-Fan 
Published: July 2021

Abstract
Parkinson’s disease (PD) is characterized pathologically by alpha-synuclein (α-Syn) aggregates and clinically by the motor as well as cognitive deficits, including impairments in sequence learning and habit learning. Using intracerebral injection of WT and A53T mutant α-Syn fibrils, we investigate the behavioral mechanism of α-Syn for procedure-learning deficit in PD by critically determining the α-Syn-induced effects on model-based goal-directed behavior, model-free (probability-based) habit learning, and hierarchically organized sequence learning. 1) Contrary to the widely held view of habit-learning deficit in early PD, α-Syn aggregates in the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) did not affect acquisition of habit learning, but selectively impaired goal-directed behavior with reduced value sensitivity. 2) α-Syn in the DLS (but not DMS) and SNc selectively impaired the sequence learning by affecting sequence initiation with the reduced first-step accuracy. 3) Adenosine A2A receptor (A2AR) antagonist KW6002 selectively improved sequence learning by preferentially improving sequence initiation and shift of sequence learning as well as behavioral reactivity. These findings established a casual role of α-Syn in the SN-DLS pathway in sequence-learning deficit and DMS α-Syn in goal-directed behavior deficit and suggest a novel therapeutic strategy to improve sequence-learning deficit in PD with enhanced sequence initiation by A2AR antagonists.
The CALCIPHYX study: a randomized, double-blind, placebo-controlled, Phase 3 clinical trial of SNF472 for the treatment of calciphylaxis
Authors: Sinha Smeeta , Gould Lisa J , Nigwekar Sagar U , Serena Thomas E , Brandenburg Vincent , Moe Sharon M , Aronoff George , Chatoth Dinesh K , Hymes Jeffrey L , Miller Stephan , Padgett Claire , Carroll Kevin J , Perelló Joan , Gold Alex , Chertow Glenn M 
Published: July 2021

ABSTRACTBackgroundCalcific uraemic arteriolopathy (CUA; calciphylaxis) is a rare disease seen predominantly in patients receiving dialysis. Calciphylaxis is characterized by poorly healing or non-healing wounds, and is associated with mortality, substantial morbidity related to infection and typically severe pain. In an open-label Phase 2 clinical trial, SNF472, a selective inhibitor of vascular calcification, was well-tolerated and associated with improvement in wound healing, reduction of wound-related pain and improvement in wound-related quality of life (QoL). Those results informed the design of the CALCIPHYX trial, an ongoing, randomized, placebo-controlled, Phase 3 trial of SNF472 for treatment of calciphylaxis.MethodsIn CALCIPHYX, 66 patients receiving haemodialysis who have an ulcerated calciphylaxis lesion will be randomized 1:1 to double-blind SNF472 (7 mg/kg intravenously) or placebo three times weekly for 12 weeks (Part 1), then receive open-label SNF472 for 12 weeks (Part 2). All patients will receive stable background care, which may include pain medications and sodium thiosulphate, in accordance with the clinical practices of each site. A statistically significant difference between the SNF472 and placebo groups for improvement of either primary endpoint at Week 12 will demonstrate efficacy of SNF472: change in Bates-Jensen Wound Assessment Tool-CUA (a quantitative wound assessment tool for evaluating calciphylaxis lesions) or change in pain visual analogue scale score. Additional endpoints will address wound-related QoL, qualitative changes in wounds, wound size, analgesic use and safety.ConclusionsThis randomized, placebo-controlled Phase 3 clinical trial will examine the efficacy and safety of SNF472 in patients who have ulcerated calciphylaxis lesions. Patient recruitment is ongoing.
Central and peripheral sympathetic activation in heart failure
Authors: Grassi Guido , Mancia Giuseppe , Esler Murray 
Published: July 2021

Abstract
The sympathetic nervous system overdrive occurring in heart failure has been reported for more than half a century. Refinements in the methodological approaches to assess human sympathetic neural function have allowed during recent years to better define various aspects related to the neuroadrenergic alteration. These include (i) the different participation of the individual regional sympathetic cardiovascular districts at the process, (ii) the role of the central nervous system in determining the neuroadrenergic overdrive, (iii) the involvement of baroreflex, cardiopulmonary reflex, and chemoreflex mechanisms in the phenomenon, which is also closely linked to inflammation and the immune reaction, (iv) the relationships with the severity of the disease, its ischaemic or idiopathic nature and the preserved or reduced left ventricular ejection fraction, and (v) the adverse functional and structural impact of the sympathetic activation on cardiovascular organs, such as the brain, the heart, and the kidneys. Information have been also gained on the active role exerted by the sympathetic activation on the disease outcome and its potential relevance as a target of the therapeutic interventions based on non-pharmacological, pharmacological, and invasive approaches, including the renal denervation, the splanchnic sympathetic nerve ablation, and the carotid baroreflex stimulation. The still undefined aspects of the neurogenic alterations and the unmet goals of the therapeutic approach having the sympathetic activation as a target of the intervention will be finally mentioned.