bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term outcome of endotherapy for pancreatic stones by using a dedicated pancreatic basket catheter
Authors: Saito Tomotaka , Nakai Yousuke , Mizuno Suguru , Isayama Hiroyuki , Sasahira Naoki , Kanai Sachiko , Noguchi Kensaku , Sato Tatsuya , Ishigaki Kazunaga , Hakuta Ryunosuke , Saito Kei , Hamada Tsuyoshi , Takahara Naminatsu , Kogure Hirofumi , Koike Kazuhiko 
Published: March 2021

AbstractBackground and AimAlthough endotherapy for pancreatic stones is less invasive compared with surgical interventions, its recurrence rate is high and residual pancreatic stones can be a cause of recurrence. We previously reported usefulness of a novel basket catheter with nitinol fine reticular structure for pancreatic stone retraction. In this retrospective study, we aimed to evaluate the long‐term outcomes of endotherapy for pancreatic stones with and without the use of this dedicated basket catheter.MethodsWe retrospectively compared patients with symptomatic pancreatic stones who underwent the initial endotherapy between 2008 and 2019. The primary outcome was the symptomatic recurrence after complete stone clearance. Secondary outcomes were the rate of complete stone clearance, complications, risk factors for recurrences, and the treatment cost.ResultsA total of 101 patients who underwent endotherapy for pancreatic stones were analyzed: 41 patients by using the dedicated basket catheter and 60 patients by only the conventional devices. The complete stone clearance was achieved in 87.8% in the dedicated basket group and 88.3% in the conventional device group. Symptomatic recurrence was observed in 16.7% of the dedicated basket group and 47.2% of the conventional device group (P < 0.01). In the multivariate analysis, the use of the dedicated basket catheter was significantly associated with the reduced risk of symptomatic recurrence (hazard ratio, 0.40; 95% confidence interval, 0.15–0.92, P = 0.031). The complication rate and the cost were comparable between the two groups.ConclusionThe use of this dedicated pancreatic basket catheter significantly reduced symptomatic recurrence after complete pancreatic stone removal.
Effects ofBacillus pumiluson growth performance, immunological indicators and gut microbiota of mice
Authors: Zhang Nanchi , Wang Li , Wei Yong 
Published: March 2021

AbstractAn increasing number ofBacillusstrains have been developed for use as animal feed additives. The aim of the current work was to evaluate the impacts ofBacillus pumilusfsznc‐09 in growth performance, organs development, blood constituents, genes expression of growth and immune in spleen and microbial communities in jejunum of weanling mice. The results showed that the body weight of mice in BP1 group increased significantly (p < 0.05) after feedingBacillus pumilusfsznc‐09. Compared with control group, the feed conversion ratio of BP1 and BP2 groups showed 13.57% (p < 0.05) and 9.64% improvements, respectively. The lengths of large intestine, small intestine in BP1 group were significantly increased (p < 0.05). While compared with control group, the organ indexes in BP1 and BP2 group did not differ significantly. Compared with control group, the activities of serum total superoxide dismutase (T‐SOD), alkaline phosphatase (AKP), lysozyme (LZM) in BP1 group and T‐SOD, AKP in BP2 group were significantly increased (p < 0.05). Compared with control group, the expressions of ghrelin‐2 (Ghrl‐2) and insulin‐like growth factor 1 (Igf1) in BP1 group were significantly increased (p < 0.05). Compared with control group, the expressions of interleukin‐6 (IL‐6), nitric oxide synthase (INOS), tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β) in BP1 group and the expressions ofIL‐6,INOS,TNF‐α,IL‐1β and interferon alpha 11 (Ifna11) in BP2 group were slightly decreased. Moreover, compared with control group, the diversity of intestinal flora and relative abundance of potentially probiotics (e.g.,Bifidobacterium,Bacillus) in BP1 and BP2 groups were increased. While compared with control group, the relative abundance of the potentially pathogenic bacterium (e.g.,Staphylococcus) was reduced. The relative abundances of dominant species in BP1 (Lactobacillus johnsonii) and BP2 (Lactobacillus reuteri) groups were also higher than control group (Lactobacillus intestinalis). In conclusion,Bacillus pumilusfsznc‐09 might improve the growth performance and immunity of mice.
Neonatal lupus erythematosus presenting as orolabial ulcerations: Two cases and a review of the literature
Authors: Drohan Alex , Snyder Alan , Plante John , Karlin Samantha , Wine Lee Lara , Cotton Colleen H. 
Published: March 2021

AbstractWe report two unrelated infants who presented with orolabial ulcerations as a presenting manifestation of neonatal lupus erythematosus (NLE). Subsequent positive anti‐SSA/SSB titers confirmed the diagnosis. In both infants, the ulcerations were painless and spontaneously resolved. NLE should be included in the differential diagnosis of orolabial ulcerations in the newborn, especially since mothers of affected infants may be asymptomatic.
A guide for many authors: Writing manuscripts in large collaborations
Authors: Moshontz Hannah , Ebersole Charles R. , Weston Sara J. , Klein Richard A. 
Published: March 2021

AbstractWriting manuscripts collaboratively affords both opportunities and challenges: Collaborative papers can benefit from the expertise, perspectives, and collective effort of the group but can lack coherence or be produced inefficiently. When collaborations are large, involving tens or hundreds of researchers, there are more and different opportunities and challenges, like appropriately crediting the contributions of many people. This paper is a practical guide for authors writing collaborative manuscripts, particularly those working in large collaborations. We emphasize the importance of deliberate leadership and describe five general strategies that lead authors can employ to maximize opportunities and navigate challenges: care in recruiting the author team, care in crediting the author team, clear and frequent communication, organized materials, and deliberate and early decision‐making. For each, we offer specific tips in line with these strategies (e.g., use collaboration agreements, leverage Open Science practices). We then suggest how lead authors can structure the writing and revising process to produce a coherent manuscript and offer tips for submitting papers and responding to peer‐reviews. A repository of resources for people writing manuscripts in collaborations is available at osf.io/dzwcn.
Glycogen supercompensation is due to increased number, not size, of glycogen particles in human skeletal muscle
Authors: Jensen Rasmus , Ørtenblad Niels , Stausholm Marie‐Louise H. , Skjærbæk Mette C. , Larsen Daniel N. , Hansen Mette , Holmberg Hans‐Christer , Plomgaard Peter , Nielsen Joachim 
Published: March 2021

New FindingsWhat is the central question of this study?Glycogen supercompensation after glycogen‐depleting exercise can be achieved by consuming a carbohydrate‐enriched diet, but the associated effects on the size, number and localization of intramuscular glycogen particles are unknown.What is the main finding and its importance?Using transmission electron microscopy to inspect individual glycogen particles visually, we show that glycogen supercompensation is achieved by increasing the number of particles while keeping them at submaximal sizes. This might be a strategy to ensure that glycogen particles can be used fast, because particles that are too large might impair utilization rate.AbstractGlycogen supercompensation after glycogen‐depleting exercise can be achieved by consuming a carbohydrate‐enriched diet, but the associated effects on the size, number and localization of intramuscular glycogen particles are unknown. We investigated how a glycogen‐loading protocol affects fibre type‐specific glycogen volume density, particle diameter and numerical density in three subcellular pools: between (intermyofibrillar) or within (intramyofibrillar) the myofibrils or beneath the sarcolemma (subsarcolemmal). Resting muscle biopsies from 11 physically active men were analysed using transmission electron microscopy after mixed (MIX), LOW or HIGH carbohydrate consumption separated by glycogen‐lowering cycling at 75% of maximal oxygen consumption until exhaustion. After HIGH, the total volumetric glycogen content was 40% [95% confidence interval 16, 68] higher than after MIX in type I fibres (P< 0.001), with little to no difference in type II fibres (9% [95% confidence interval −9, 27]). Median particle diameter was 22.5 (interquartile range 20.8–24.7) nm across glycogen pools and fibre types, and the numerical density was 61% [25, 107] and 40% [9, 80] higher in the subsarcolemmal (P< 0.001) and intermyofibrillar (P< 0.01) pools of type I fibres, respectively, with little to no difference in the intramyofibrillar pool (3% [−20, 32]). In LOW, total glycogen was in the range of 21–23% lower, relative to MIX, in both fibre types, reflected in a 21–46% lower numerical density across pools. In comparison to MIX, particle diameter was unaffected by other diets ([−1.4, 1.3] nm). In conclusion, glycogen supercompensation after prolonged cycling is exclusive to type I fibres, predominantly in the subsarcolemmal pool, and involves an increase in the numerical density rather than the size of existing glycogen particles.
Oil-Based Drilling Fluid's Cuttings Bed Removal Properties for Deviated Wellbores
Authors: Ytrehus Jan David , Lund Bjørnar , Taghipour Ali , Carazza Luca , Gyland Knud Richard , Saasen Arild 
Published: March 2021

Abstract
Results from cuttings transport tests in the laboratory using different field-applied oil-based drilling fluids with similar weight and varying viscosities are presented in this paper. The fluids are designed for highly deviated wells, and the cuttings transport performance at relevant wellbore inclinations was investigated. The experiments have been performed in a flow loop that consists of a 10-m-long test section with 50.4 mm (2″) diameter freely rotating steel drill string inside a 100-mm (≈4″) diameter wellbore made of cement. Sand particles were injected while circulating the drilling fluid through the test section. Experiments were performed at three wellbore inclinations: 48, 60, and 90 deg from vertical. The applied flow loop dimensions are designed so that the results are scalable to field applications; especially for the 12 ¼″and 8 ½″ sections. The selected setup provides correct shear rate ranges and similar Reynolds numbers to the field application when the same fluids are applied. Results show that hole cleaning abilities of the tested fluids vary significantly with well angle, drill string rotation, and flowrate. Results support field experience showing that low viscous fluids are more efficient than viscous fluids at higher flowrates and low drill string rotation. As well as per field experience, more viscous fluids are efficient in combination with high drill string rotation rates. The results show the effect of cuttings transport efficiency as a function of hydraulic frictional pressure drop, demonstrating methods to achieve a more optimal hydraulic design in the tested conditions. The key findings have direct relevance to drilling operations.
Incentivizing Stable Path Selection in Future Internet Architectures
Authors: Scherrer Simon , Legner Markus , Perrig Adrian , Schmid Stefan 
Published: March 2021

By delegating path control to end-hosts, future Internet architectures offer flexibility for path selection. However, a concern arises that the distributed routing decisions by endhosts, in particular load-adaptive routing, can lead to oscillations if path selection is performed without coordination or accurate load information. Prior research has addressed this problem by devising local path-selection policies that lead to global stability. However, little is known about the viability of these policies in the Internet context, where selfish end-hosts can deviate from a prescribed policy if such a deviation is beneficial from their individual perspective. In order to achieve network stability in future Internet architectures, it is essential that end-hosts have an incentive to adopt a stability-oriented path-selection policy.
In this work, we perform the first incentive analysis of the stability-inducing path-selection policies proposed in the literature. Building on a game-theoretic model of end-host path selection, we show that these policies are in fact incompatible with the self-interest of end-hosts, as these strategies make it worthwhile to pursue an oscillatory path-selection strategy. Therefore, stability in networks with selfish endhosts must be enforced by incentive-compatible mechanisms. We present two such mechanisms and formally prove their incentive compatibility.
Load-Optimization in Reconfigurable Networks
Authors: Dai Wenkai , Foerster Klaus-Tycho , Fuchssteiner David , Schmid Stefan 
Published: March 2021

Emerging reconfigurable data centers introduce the unprecedented flexibility in how the physical layer can be programmed to adapt to current traffic demands. These reconfigurable topologies are commonly hybrid, consisting of static and reconfigurable links, enabled by e.g. an Optical Circuit Switch (OCS) connected to top-of-rack switches in Clos networks. Even though prior work has showcased the practical benefits of hybrid networks, several crucial performance aspects are not well understood.
In this paper, we study the algorithmic problem of how to jointly optimize topology and routing in reconfigurable data centers with a known traffic matrix, in order to optimize a most fundamental metric, maximum link load. We chart the corresponding algorithmic landscape by investigating both un-/splittable flows and (non-)segregated routing policies. We moreover prove that the problem is not submodular for all these routing policies, even in multi-layer trees, where a topological complexity classification of the problem reveals that already trees of depth two are intractable.
However, networks that can be abstracted by a single packet switch (e.g., nonblocking Fat-Tree topologies) can be optimized efficiently, and we present optimal polynomialtime algorithms accordingly. We complement our theoretical results with trace-driven simulation studies, where our algorithms can significantly improve the network load in comparison to the state of the art.
Creation of State Antibiogram and Subsequent Launch of Public Health–Coordinated Antibiotic Stewardship in New Hampshire: Small State, Big Collaboration
Authors: Leeman Hannah M. , Chan Benjamin P. , Zimmermann Carly R. , Talbot Elizabeth A. , Calderwood Michael S. , Dave Apara R. , Santos Paul , Hansen Katrina E. 
Published: March 2021

Background: An antibiogram is a summary of antibiotic susceptibility patterns for selected bacterial pathogens and antibiotics. The New Hampshire Department of Health and Human Services’ Division of Public Health Services (DPHS) sought to create an annual state antibiogram to monitor statewide antibiotic resistance trends, guide appropriate empiric antibiotic prescribing, and inform future statewide antibiotic stewardship. Methods: Through legislative authority, DPHS required hospital laboratories to report antibiogram data annually. DPHS convened an advisory group of infectious disease and pharmacy stakeholders and experts to develop a standardized reporting form for bacteria and antibiotic susceptibility, which was disseminated to all 26 hospitals in New Hampshire. We combined the reported data into a statewide antibiogram, and we created clinical messaging to highlight findings and promote rational antibiotic prescribing among health care providers. Results: All hospital laboratories in New Hampshire submitted annual antibiogram data for 2016 and 2017, including more than 30 000 and 20 000 bacterial isolates recovered from urine and nonurine cultures, respectively, each year. The advisory group created clinical messages for appropriate treatment of common infectious syndromes, including uncomplicated urinary tract infections, community-acquired pneumonia, skin and soft-tissue infections, intra-abdominal infections, and health care–associated gram-negative aerobic infections. The statewide antibiograms and clinical messaging were widely disseminated. Conclusions: The small size of New Hampshire, a centralized public health structure, and close working relationships with hospitals and clinical partners allowed for efficient creation and dissemination of an annual statewide antibiogram, which has fostered public health–clinical partnerships and built a foundation for future state-coordinated antibiotic stewardship. This process serves as a model for other jurisdictions that are considering antibiogram development.
Psychometric Evaluation of the Intolerance of Uncertainty Scale for Children (IUSC): Findings From Clinical and Community Samples in Iran
Authors: Zemestani Mehdi , Didehban Reza , Comer Jonathan S. , Kendall Philip C. 
Published: March 2021

Objective: The present study examined the psychometric properties of a Persian version of the Intolerance of Uncertainty Scale for Children (IUSC; Comer et al, 2009). Method: Participating youth ( n = 346) 8 to 18 years of age were nonreferred community youth ( n = 279) or youth who met diagnostic criteria for an anxiety disorder ( n = 67) and their parents. Results: Across child- and parent-report data, confirmatory factor analysis supported a shortened 12-item version of the IUSC, and the confirmatory factor analysis also confirmed a theory-driven correlated two-factor structure of the IUSC-12. (i.e., prospective/inhibitory IU). Results further supported reliability and validity of parent- and child-reports of the Persian IUSC-12 via evidence of internal consistency, 4-week retest, significant associations with established measures of internalizing problems, and the ability of the measure to reliably distinguish the clinical sample from the community sample. Conclusion: Findings demonstrate sound psychometric properties of the Persian version of the IUSC-12 and provide additional support for the reliability and validity of the measure and its use in non-Western cultures. Findings are discussed in terms of implications for assessment, treatment, and study of anxiety and related internalizing problems in Iranian youth.
Transfer of the supinator nerve to the posterior interosseous nerve for hand opening in tetraplegia through an anterior approach
Authors: van Zyl Natasha , Galea Mary P , Cooper Catherine , Hahn Jodie , Hill Bridget 
Published: March 2021

We report a retrospective series of 44 transfers in 26 patients in whom a functioning supinator nerve was transferred to a paralyzed posterior interosseous nerve through a single, anterior approach to re-animate hand opening in mid-cervical tetraplegia. Eighteen patients underwent concurrent nerve or tendon transfers to re-animate grasp and/or pinch through the same anterior incision. We evaluated the strength of the innervated muscle at mean follow-up of 24 months (range 12–27). The strength attained in our patients was equivalent to the strength after the transfer through a posterior approach reported in the literature. Nineteen of our patients were satisfied with the hand opening procedure. First webspace opening was the only variable to correlate with patient satisfaction. We conclude that the anterior approach yields similar results to the posterior approach and has the advantage of allowing easier access for simultaneously performing nerve or tendon transfers to reconstruct grasp and pinch. Level of evidence: IV
Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis
Authors: Pfeuffer Steffen , Kerschke Laura , Ruck Tobias , Rolfes Leoni , Pawlitzki Marc , Albrecht Philipp , Wiendl Heinz , Meuth Sven G. 
Published: March 2021

Background and aims: Various attempts have been made to support recovery following optic neuritis (ON), but the respective trials have mostly been negative. The aim of this study was to determine whether disease-modifying treatment (DMT) following ON as first manifestation of relapsing-remitting multiple sclerosis influences long-term outcomes. Methods: A total of 79 patients with ON were identified and evaluated at relapse, DMT induction, and 12 months following treatment induction with either glatiramer acetate (GLAT), interferon-beta (IFN), or teriflunomide (TRF). Low-contrast letter acuity (LCLA) and full-field visual-evoked potentials (FF-VEP) were compared between treatment groups using multivariable regression models. The impact of TRF treatment induction compared with IFN or GLAT following relapses outside the optic nerves was evaluated in an independent cohort of 122 patients. Magnetic resonance imaging (MRI) outcomes and rates of confirmed improvement of relapse-related disability were evaluated. Results: TRF-treated patients exhibited higher LCLA and lower relative P100 latencies normalized to the fellow-eye. Findings were significant following covariate-adjustment by multivariable analyses. Cranial MRI lesion load as well as disability progression rates were not significantly different between groups. The cohort of patients following relapses other than ON showed no differences in confirmed improvement of disability. Conclusion: TRF treatment is associated with favorable outcomes regarding functional optic nerve recovery following ON in early multiple sclerosis.
A Pilot Study Evaluating the Timing of Vestibular Therapy After Sport-Related Concussion: Is Earlier Better?
Authors: Ahluwalia Ranbir , Miller Scott , Dawoud Fakhry M. , Malave Jose O. , Tyson Heidi , Bonfield Christopher M. , Yengo-Kahn Aaron M. 
Published: March 2021

Background: Vestibular dysfunction, characterized by nausea, dizziness, imbalance, and/or gait disturbance, represents an important sport-related concussion (SRC) subtype associated with prolonged recovery. Vestibular physical therapy promotes recovery; however, the benefit of earlier therapy is unclear. Hypothesis: Earlier vestibular therapy for young athletes with SRC is associated with earlier return to play (RTP), return to learn (RTL), and symptom resolution. Study Design: Retrospective cohort study. Level of Evidence: Level 3. Methods: Patients aged 5 to 23 years with SRC who initiated vestibular rehabilitation therapy (VRT) from January 2019 to December 2019 were included and patient records were reviewed. Therapy initiation was defined as either early, ≤30 days postinjury, or late (>30 days). Univariate comparisons between groups, Kaplan-Meier plots, and multivariate Cox proportional hazard modeling were performed. Results: Overall, 23 patients (10 early, 13 late) aged 16.14 ± 2.98 years and 43.5% were male patients. There was no difference between group demographics or medical history. Median initial total and vestibular symptom scores were comparable between groups. The late therapy group required additional time to RTP (110 days [61.3, 150.8] vs 31 days [22.5, 74.5], P = 0.03) and to achieve symptom resolution (121.5 days [71, 222.8] vs 54 days [27, 91], P = 0.02), but not to RTL (12 days [3.5, 26.5] vs 17.5 days [8, 20.75], P = 0.09). Adjusting for age and initial total symptom score, earlier therapy was protective against delayed symptom resolution ( P = 0.01). Conclusion: This pilot study suggests that initiating VRT within the first 30 days after SRC is associated with earlier RTP and symptom resolution. Further prospective trials to evaluate if even earlier VRT should be pursued to further improve recovery time. Clinical Relevance: Clinicians should screen for vestibular dysfunction and consider modifying follow-up schedules after SRC to initiate VRT within a month of injury for improved outcomes.