bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simvastatin is effective in killing the radioresistant breast carcinoma cells
Authors: Aschenbrenner Bertram , Negro Giulia , Savic Dragana , Sorokin Maxim , Buzdin Anton , Ganswindt Ute , Cemazar Maja , Sersa Gregor , Skvortsov Sergej , Skvortsova Ira 
Published: May 2021

Abstract

Background
Statins, small molecular 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are widely used to lower cholesterol levels in lipid-metabolism disorders. Recent preclinical and clinical studies have shown that statins exert beneficial effects in the management of breast cancer by increasing recurrence free survival. Unfortunately, the underlying mechanisms remain elusive.

Materials and methods
Simvastatin, one of the most widely prescribed lipophilic statins was utilized to investigate potential radiosensitizing effects and an impact on cell survival and migration in radioresistant breast cancer cell lines.

Results
Compared to parental cell counterparts, radioresistant MDA-MB-231-RR, T47D-RR andAu565-RR cells were characterized by upregulation of 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR) expression accompanied by epithelial-to-mesenchymal transition (EMT) activation. Radioresistant breast cancer cells can be killed by simvastatin via mobilizing of a variety of pathways involved in apoptosis and autophagy. In the presence of simvastatin migratory abilities and vimentin expression is diminished while E-cadherin expression is increased.

Conclusions
The present study suggests that simvastatin may effectively eradicate radioresistant breast carcinoma cells and diminish their mesenchymal phenotypes.
Recasts, prompts and noticing: A comparative study
Authors: Siow Chin Choo , Pillai Stefanie , Zainuddin Siti Zaidah 
Published: May 2021

Noticing has been regarded as an important theoretical construct in the mechanism of how corrective feedback (CF) facilitates second language acquisition. However, to date, only a paucity of CF research has examined noticing triggered by different types of CF (i.e., recasts vs. prompts). The study is intended to fill in the gap by examining the relationships between type of CF and level of noticing. To that end, 105 Malaysian ESL learners were asked to perform four communicative tasks during which recasts and prompts were provided contingent upon the encounter of past tense errors. To assess noticing, the study has employed a triangulated method using multiple elicitation procedures including diary writing, stimulated recall, and exit questionnaire. The results of the study revealed that both recasts and prompts were able to induce noticing the corrective intent, noticing the target of CF or form, noticing the gap, and noticing the rule. However, contrary to what was expected, recasts were able to promote higher levels of noticing across all noticing categories. Moreover, the greatest difference between recasts and prompts was found in noticing the gap. The study suggests that CF that provides exemplars of the target linguistic feature may promote higher levels of noticing the gap which may, in turn, increase the effectiveness of CF in L2 acquisition.
Cultural Fit of Assessments to Detect Curiosity for Weak Signals Among Employees
Authors: Amaral Thais , Behrens Alfredo 
Published: May 2021

To remain competitive, organizations must make sense of antecedent weak signals that might yield information on opportunities or threats. However, perceiving those signals requires psychological capabilities which are not evenly distributed over their workforce. Identifying who might effectively sense weak antecedent signals is the necessary first step in the staff selection and management process. To this effect, Human Resources Management processes at organizations rely on assessments. However, this study suggests that some self-assessments might be too context-sensitive to fit their purpose across cultures. In particular, the CEI-II evaluation applied to a small and convenience sample of Brazilian executives did not satisfy Brazilian respondents’ selection for curiosity. The authors briefly discuss how the Brazilian context may differ, not least because of a considerably lower generalized trust level, and suggest relying alternatively on projective instruments.
Mucosa gástrica heterotópica em vesícula biliar: relato de caso
Authors: Lima Flávia Medeiros , De Oliveira Diego Henrique , Oliveira Gabriel Oliveira Leite de , Scopacasa Edgard Costa , Kistenmacker Fabio Jorge Neubaner 
Published: May 2021

Introdução: A heterotopia pode ser definida como a ocorrência de tecido bem diferenciado em um local anormal, um sinônimo utilizado por alguns autores é “coristoma” (Choristosgregos = separados), o que denota uma massa de tecido histologicamente normal localizado em um local não habitual. Tecidos heterotópicos de vários tipos foram descritos na literatura, tais como mucosa gástrica e mucosa intestinal, comparando com todo o trato gastrointestinal, relatos de mucosa gástrica heterotópica na vesicular biliar são extremamente raros. Objetivo: Divulgar um caso atípico de mucosa gástrica heterotópica em vesicular biliar em paciente do Hospital Escola de Valença, com seu consequente desfecho, através da análise de prontuário.Relato de caso: Mulher de 41 anos atendida no Hospital Escola de Valença apresentando dor recorrente em hipocôndrio direito e região epigástrica, distensão abdominal, náuseas e icterícia, sendo diagnosticada com heterotopia de mucosa gástrica em vesícula biliar e submetida à colecistectomia videolaparoscópica. Conclusão: O diagnóstico deve sempre ser considerado em pacientes jovens com colecistite alitiásica e em qualquer tipo de alteração morfológica da vesícula, devido à associação existente entre esta alteração e o aumento de risco de câncer.
2. Wild Wild East: The Animal as Oriental
Authors: Atta Pansee 
Published: May 2021

Horus, centaurs, werewolves, Batman...every culture has them. Fantastic animal‐human hybrids that serve as totems, symbols of basic human needs and instincts deemed socially unacceptable and projected upon anthropomorphized living animals or imagined liminal beings. This allows humans to define themselves as civilized, restrained, rational ‐ all that is not ‘animal’‐ while allowing them an imaginary, socially sanctioned context in which they can live out their hedonistic desires. Animal biology becomes a construction that allows humans to define themselves in its opposition, in other words, it is Orientalized. The paradox is that these ‘animalistic’ traits are the closest we come to seeing that which is truly, essentially human. Norms of sexuality and violence may be culturally defined, but there is no culture that lacks a definition. Understanding ‘animal instincts’ becomes an entry point into another way of viewing the world, a means of accessing human experience, and a response to the dialogue on cultural hybridity.
PELATIHAN PEMBUATAN MEDIA INTERAKTIF BERBASIS POWER POINT UNTUK GURU SMA DALAM MENGHADAPI REVOLUSI INDUSTRI 4.0
Authors: Hartawan I Nyoman Buda 
Published: May 2021

Tingkat pendidikan masyarakat di suatu Negara menentukan perkembangan dari Negara tersebut. Peserta didik saat ini merupakan generasi yang secara karakter memiliki perbedaan dengan generasi sebelumnya, sehingga memerlukan metode pembelajaran yang juga berbeda. Penyajian materi secara menarik dan interaktif menjadi salah satu cara untuk mampu menarik perhatian peserta didik selama kegiatan belajar mengajar. Pada kegiatan tersebut terjadi proses transformasi pengetahuan dari guru kepada peserta didiknya. Hal ini menyebabkan perlu adanya media pembelajaran yang tepat agar proses transformasi pengetahuan dapat berjalan dengan lancar. Kegiatan pelatihan yang dilakukan adalah pembuatan media interaktif berbasis power point untuk guru SMA. Pelatihan ini menjadi solusi praktis yang mampu membantu guru dalam menyajikan materi pembelajaran yang menarik, interaktif, dan berbasis teknologi. Untuk mengukur tingkat keberhasilan kegiatan ini, peserta pelatihan diberikan tugas untuk menyelesaikan sebuah project membuat media interaktif. Dari hasil penilaian yang dilakukan terdapat 78% peserta selesai mengerjakan project sesuai dengan waktu yang ditentukan, sedangkan 22% belum selesai mengerjakan project. Meskipun demikian, kegiatan ini dinilai bermanfaat dan berhasil membantu guru dalam membuat media interaktif dengan memanfaatkan teknologi sesuai dengan bidang ilmunya masing-masing
Assessing Effect of The Factors that Influence Financial Reporting Information Quality
Authors: Bawono Icuk Rangga , Suroso Agus , Yuniarso Gema Puja 
Published: May 2021

A particular form of information used as user requirements for the process of decision-making. A qualified information is important for interested party who used that information to reduce uncertainty and knowledge upgrade on the specific concern areas. By considering information is a wishful move for doing an activity. The information quality of financial statements that the government publishes in public has to meet standards to be trusted and used by people so people could rely on for making a decision. The objective to do this research is to verify relationship between human resources competency, accounting information system, and internal control on accounting information quality of government financial statements. The paradigm of this research is quantitative research. The sampling method used is a nonprobability sampling (saturated sampling) with quota. The research was conducted by distributing questionnaires to 43 respondents who are SIMDA operator on the government work unit of Central Sulawesi Provincial Government. Multiple linear regression analysis used to analyze data. The results showed that human resources competency, accounting information system, and internal control have a positive effect on the quality of financial reporting information in Central Sulawesi Provincial Government.
IDENTIFICACIÓN DEL TIPO DE INTELIGENCIA COMO POTENCIADOR DE HABILIDADES COGNITIVAS EN NIÑOS DE EDUCACIÓN GENERAL BÁSICA. // IDENTIFICATION OF THE TYPE OF INTELLIGENCE AS A COGNITIVE SKILLS ENHANCER IN CHILDREN OF BASIC GENERAL EDUCATION
Authors: Zambrano Villalba Carmen , Díaz Estrella Mauricio 
Published: May 2021

En esta investigación, se estudió la relación existente entre el tipo de inteligencias múltiples, inteligencia emocional y el nivel cognitivo de los niños de educación general básica en sus procesos de aprendizaje, a partir de una muestra de 110 niños y niñas, en edades entre 11 a 13 años, del séptimo año de educación general básica de la Parroquia Roberto Astudillo del Cantón Milagro. El objetivo del estudio fue establecer el tipo de inteligencia múltiple que predominó en dicha muestra acorde a sus actividades de aprendizaje en correlación al nivel de desarrollo de la inteligencia emocional. Para la recopilación de información se utilizó el test de Inteligencia Múltiple de Howard Gardner, el cual cuenta con 35 ítems especializado para la población infantil y el test de Inteligencia Emocional de Daniel Goleman, el mismo que cuenta con 68 ítems. Los datos fueron analizados de forma descriptiva y correlacional. Entre las conclusiones más relevantes, se estableció que, a mayor nivel de inteligencia emocional, mayor variabilidad en inteligencias múltiples, así como mayores promedios de calificaciones, resultados que influyeron en los procesos cognitivos del aprendizaje en los escolares evidenciados en los patrones de calificaciones estandarizadas AbstractIn this research, we studied, the relationship between the type of multiple intelligences, emotional intelligence and the children cognitive level of general basic education in their learning processes, from a sample of 110 boys and girls between 11 and 13 ages, of the seventh grade of General Basic Education placed in Roberto Astudillo Town in Milagro City. The objective of the study was to establish the type of multiple intelligences that predominates on this sample according to their learning activities correlated to the development level in the emotional intelligence. To the data collection; The Howard Gardner Multiple Intelligence test, which has 35 specialized items for children population and the Daniel Goleman Emotional Intelligence test, with 68 items as well. The data were analyzed descriptively and correlationally. Among the most relevant conclusions, it was established that, at a higher level of emotional intelligence, and a greater variability in multiple intelligences, as well as higher average grades, these results influenced in the cognitive processes of learning in schoolchildren, they were evidenced in standardized grading patterns
Riesgos psicosociales y satisfacción laboral en empresas que prestan servicios de salud ocupacional: un estudio en la ciudad de Guayaquil
Authors: Espinoza-Guerra Evelyn , Quimí-Espinosa Johanna , Escobar-Segovia Kenny , Camacho-Polo Isabel 
Published: May 2021

Esta investigación se ha desarrollado en el ámbito de la Seguridad y la Salud Laboral. Su finalidad fue determinar la relación existente entre los riesgos psicosociales y la satisfacción laboral en una muestra de 100 trabajadores (30 % hombre y 70 % mujeres) de dos empresas que brindan servicios integrales de salud ocupacional en la ciudad de Guayaquil-Ecuador. El estudio se realizó entre los meses de enero a febrero del 2020, para el tratamiento de datos se utilizó el el software estadístico Statistical Package for the Social Sciences (SPSS) en su versión 23. Se aplicaron dos instrumentos (Satisfacción Laboral 20/23 y el de Riesgos Psicosociales elaborado por el Misterio de Trabajo) a las y los trabajadores de diferentes áreas de la organización. Los resultados indican que no existe relación significativa entre las características sociodemográficas, los riesgos psicosociales y la satisfacción laboral de los y las colaboradoras. Por otro lado, en la relación entre las variables: Factores de Riesgo Psicosocial y Satisfacción Laboral y sus respectivas dimensiones, se pudo observar que existe una correlación negativa significativa entre ellas, es decir, que, a mayor nivel de riesgo psicosocial percibido en el trabajo, menor nivel de satisfacción laboral. Estos resultados evidencian la necesidad de realizar un programa que minimice los riesgos psicosociales en el área de trabajo
¿Confías en esta Fuente?: Percepción de Credibilidad de Fuentes Documentales y No-Documentales en Estudiantes Universitarios
Authors: Londra Franco , Politti Mariana , Saux Gastón 
Published: May 2021

El Objetivo de la investigación fue examinar la percepción de credibilidad de una serie fuentes de información en función de sus características en una muestra de estudiantes universitarios.
Metodología: experimental, diseño transversal. Procedimientos: Participaron 120 estudiantes de psicología (edad M = 20,64, DS = 4,05, 80,4 % mujeres). Cada participante evaluó la credibilidad de siete fuentes diferentes (cuatro documentales y tres no documentales) para tratar un tema médico poco conocido. Resultados: Se encontraron tres resultados principales. Primero, la evaluación de credibilidad se vio influenciada por las características de las (e.g., fuentes, su experticia, su acceso a información de primera mano y la presencia de un filtro editorial) para establecer cuánto confían en las fuentes. Segundo, algunas características resultaron más prominentes que otras. Tercero, el conocimiento previo temático de los participantes afectó la influencia de las características de las fuentes sobre la evaluación de credibilidad. Conclusiones: Los resultados brindan información sobre cómo distintos parámetros o características de las fuentes influyen en su evaluación de credibilidad, pudiendo orientar el diseño de intervenciones desinadas a promover la evaluación crítica de documentos.
Rememoriar para resistir:
Authors: Silva Adriana Pereira da 
Published: May 2021

O presente artigo traz em memória uma experiência de política pública municipal de Educação Profissional integrada com a Educação de Jovens e Adultos na etapa do Ensino Fundamental. A pesquisa objetiva evidenciar o processo de construção da política pública local, observando suas especificidades curriculares e sua aproximação com a política nacional de formação integral de trabalhadores (as), no período de 2004 a 2016. A investigação é de caráter qualitativo, sistematizada num perfil de estudo de documentos. Para organização dessa metodologia tem-se um tratamento do perfil da política municipal e há uma análise dessa experiência em atenção ao Decreto 5154/04 e ao Documento do Programa Nacional de Integração da Educação Profissional com a Educação Básica na modalidade da Educação de Jovens e Adultos (PROEJA). Assim, a sistematização partiu dos documentos específicos do município em estudo e dos documentos das políticas nacionais citadas. A reflexão está fundamentada na análise das categorias formação integral e trabalho como princípio educativo. O referencial teórico filia-se a concepção de educação critico-humanística. A conclusão evidenciou que a política municipal teve proximidades com a política nacional, pois apresentava um compromisso de educação de trabalhadores (as) em perspectiva emancipatória, sustentada nos princípios fundantes da formação integral, além disso, elucidou caminhos próprios, retratando especificidades curriculares que mostraram ser significativas para uma proposta de Educação Profissional de base crítica.
Kiat menghadapi COVID-19 untuk orang sehat
Authors: Saswati Nofrida , Parman Parman , Andriani Medi , Afrida Erni 
Published: May 2021

Indonesia masih dilanda wabah pandemik COVID-19, sama dengan negara lain di Dunia. Jumlah kasus COVID-19 terus bertambah dengan beberapa melaporkan kesembuhan, tapi tidak sedikit yang meninggal. Usaha penanganan dan pencegahan terus dilakukan demi melawan COVID-19 dengan gejala mirip flu. munculnya pandemi menimbulkan stres pada berbagai lapisan masyarakat. Meskipun sejauh ini belum terdapat ulasan sistematis tentang dampak COVID-19 terhadap kesehatan jiwa, namun sejumlah penelitian terkait pandemi (antara lain flu burung dan SARS) menunjukkan adanya dampak negatif terhadap kesehatan mental penderitanya. Siswa SMK DB 1 kelas XII merupakan kelompok orang sehat, dimana siswa tersebut melakukan pembelajaran secara online dan offline. Pembelajaran offline sangat berisiko bagi orang yang sehat untuk terkonfirmasi COVID-19, maka dari itu kami melakukan pengabdian kepada masyarakat kepada siswa SMK DB 1 kelas XII tentang Kiat Menghadapi Covid-19 untuk Orang Sehat (OS) agar terhindar dari penularan covid 19.Metode pada pengabdian ini dilakukan dengan ceramah, diskusi dan demonstrasi. Hasil setelah dilakukan kegiatan pengabdian ini didapatkan pengetahuan baik sebanyak 78% dan pengetahuan cukup sebanyak 22%.
Hasil pengabdian terdapat peningkatan pengetahuan tentang kiat menghadapi COVID-19 untuk orang sehat bagi siswa SMK DB 1 kelas XII, diharapkan pihak sekolah selalu meningkatkan upaya dalam kiat menghadapi COVID-19 bagi seluruh siswa SMK DB 1
Determining Bullying Text Classification Using Naive Bayes Classification on Social Media
Authors: Sitepu Ade Clinton , Wanayumini Wanayumini , Situmorang Zakarias 
Published: May 2021

Cyber-bullying includes repeated acts with the aim of scaring, angering, or embarrassing those who are targeted Cyber-bullying is happening along with the rapid development of technology and social media in society. The media and users need to filter out bully comments because they can indirectly affect the mental psychology that reads them especially directly aimed at that person. By utilizing information mining, the system is expected to be able to classify information circulating in the community. One of the classification techniques that can be applied to text-based classification is Naïve Bayes. The algorithm is good at performing the classification process. In this research, the precision of the algorithm's has been carried out on 1000 comment datasets. The data is grouped manually first into the labels "bully" and "not bully" then the data is divided into training data and test data. To test the system's ability, the classified data is analyzed using the confusion matrix method. The results showed that the Naïve Bayes Algorithm got the level of precision at 87%. and the level of area under the curve (AUC) at 88%. In terms of speed of completing the system, the Naïve Bayes Algorithm has a very good rate of speed with completion time of 0.033 seconds.
SYSTEMS FOR ACTIVE MONITORING OF ROTOR BEARING STATE IN TURBINE GENERATOR OF MICRO-TURBINE INSTALLATION
Authors: Kirichek Alexey 
Published: May 2021

The paper is dedicated to the increase of reliability, life, resource and decrease of costs for maintenance of micro-turbine installations at the expense of rotor bearing timely maintenance and decrease of total work time of the installation in the mode of catastrophic wear.
In the paper there is described a method for the active monitoring of rotor bearing state of the micro-turbine installation allowing timely notification of the workers in charge about essential turbine generator maintenance.
The solution offered is fundamentally new in this field of investigations as it was not used earlier for the control of rotor bearing state of turbine generators. In the paper there are enumerated all components essential for the operation of the system and a method for their connection. A process for adjustment and updating the solution offered is described. As a basic component of the system for data collection there is used Arduino Uno controller. As a main software component is chosen Zabbix 5.0 monitoring system. The objects under investigation are described, and there are presented conclusions on effectiveness and economic purposefulness of the solution offered.
Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study
Authors: Lingaldinna Swapna , Konda Kalyan Chakravarthy , Bapanpally Narahari , Alimelu Madireddy , Singh Himabindu , Ramaraju Meghna 
Published: May 2021

Introduction: Bilirubin is a frequently ordered investigation in neonatal intensive care units and out-patient practice during follow- up. The gold standard for its estimation is serum bilirubin which is invasive resulting in parenteral apprehension, pain, discomfort and iatrogenic anaemia in a neonate, while the non-invasive measurement by transcutaneous bilirubinometer is not available in all the centres because of its cost. Biliscan is a smartphone application that uses a phone’s inbuilt camera and a colour calibration card to detect neonatal jaundice. We compared bilirubin measured by Biliscan with reference to serum bilirubin among neonates admitted to a tertiary care centre.
Methods: We conducted an observational study from June-2019 to September-2019 at a tertiary care centre in Hyderabad, India. Inborn neonates (greater than > 35 weeks gestational age at birth, and less than a week old) who required bilirubin estimation, underwent both invasive serum sampling and non-invasive estimation by Biliscan. Photograph of the baby’s chest was captured using the colour calibration card of the Biliscan application. Bilirubin values derived from the Biliscan application were compared to those derived from blood samples.
Results: A total of 143 neonates were enrolled. The mean bilirubin value estimated by serum sampling was 11.9 g/dl against 13.1 g/dl of that derived from smartphone application. Biliscan and serum bilirubin showed moderate agreement with a correlation coefficient of 0.6. Bland- Altman plot constructed showed bias of 1.1 with the limits of agreement ranging from -3 to +5.3. Biliscan had a good sensitivity of 90% in identifying high levels of serum bilirubin (> 95th percentile on Bhutani nomogram).
Conclusion: Biliscan application is a non-invasive, real-time, inexpensive and an easily available method that cannot replace serum bilirubin, however can complement and has the potential to help in screening neonates thus facilitating recognition of jaundice early and minimising the number of invasive pricks.