bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMULATION AND EVALUATION OF BILAYERED FELODIPINE TRANSDERMAL PATCHES: IN VITRO AND EX VIVO CHARACTERIZATION
Authors: M KEERTHANA , S SHIRISHA , SUNIT KUMAR SAHOO , RAO Y MADHUSUDAN 
Published: March 2021

Objective: Felodipine (FD) is an effective Biopharmaceutics Classification System Class II calcium channel blocker mainly used in the management of hypertension and angina pectoris. It has poor solubility and low oral bioavailability (15%). To overcome these disadvantages and to maintain constant plasma concentration for maximum therapeutic activity, there is a need to design an alternative route, that is, transdermal route. The pharmacokinetic parameters make FD a suitable candidate for transdermal delivery. The present investigation consists of the study of in vitro and ex vivo skin flux of FD from bilayered transdermal patches.
Methods: The patches were fabricated by solvent casting method using hydrophilic and hydrophobic polymer with different composition. Tween 80 incorporated as solubilizer, polyethylene glycol 600 as plasticizer, menthol, eucalyptus oil, and lemongrass oil used as permeation enhancers, respectively. The prepared transdermal drug delivery system was extensively evaluated for in vitro release, ex vivo permeation through pig ear skin, moisture content, moisture absorption, water vapor transmission, and mechanical properties. The physicochemical interaction between FD and polymers was investigated by Fourier-transform infrared (FTIR) spectroscopy.
Results: All the formulations exhibited satisfactory physicochemical and mechanical characteristics. A flux of 35.2 μg/cm2 h, 27.9 μg/cm2 h, and 25.25 μg/cm2 h was achieved for optimized formulations containing lemongrass oil, eucalyptus oil, and menthol, respectively, permeation enhances. Values of tensile strength (0.0652±0.034 kg/mm²) and elongation at break (0.8749±0.0.0029% mm²) revealed that formulation F9 was strong but not brittle. Drug and excipients compatibility studies showed no evidence of interaction between the active ingredient and polymers.
Conclusion: Bilayered FD transdermal patches could be prepared with required flux and suitable mechanical properties.
Diabetes Distress, Daily Functioning, and A1C in Older Black Individuals With Diabetes and Mild Cognitive Impairment
Authors: Barman Navajyoti R. , Casten Robin J. , Rovner Barry W. 
Published: March 2021

OBJECTIVE
The purpose of the cross-sectional study was to identify associations of diabetes distress, physical functioning, and cognition with A1C in older Black individuals with diabetes and mild cognitive impairment.

METHODS
The investigators analyzed previously collected data from 101 older Black individuals with diabetes and mild cognitive impairment. Participants were administered surveys at baseline to assess diabetes distress, physical functioning, and cognitive functioning and had A1C testing.

RESULTS
The mean age of participants was 68.4 years, and 62% were women. Participants with higher A1C showed worse self-reported daily functioning (r = −0.28, P &lt;0.01). Three of four diabetes distress factors were positively correlated with A1C: emotional (r = 0.28, P &lt;0.01), regimen-related (r = 0.33, P &lt;0.01), and interpersonal distress (r = 0.27, P &lt;0.01). In a multivariate regression with A1C as the dependent variable, only regimen-related diabetes distress (β = 0.32, P = 0.008) and self-reported daily functioning (β = −0.33, P = 0.019) were significant.

CONCLUSION
Regimen-related diabetes distress and self-reported daily functioning were found to compromise glycemic control in Black individuals with mild cognitive impairment and diabetes. This finding suggests that diabetes interventions should be multifaceted to improve glycemic control in the high-risk population of Black individuals with diabetes.
Factors Influencing Cyberbullying Behavior among Malaysian Tertiary Students
Authors: Abdul Rahman Nor Azian , Hussein Norashikin , Rusdi Syezreen Dalina , Abd Aziz Zarith Delaila 
Published: March 2021

Cyberbully is an evolvement from traditional and physical bully to bullying through internet. The advancement of internet and social media has provided new platform through which children, adolescents, and young adults to explore the virtual world and exposes them to be involved in cyberbully as a target or an aggressor. Past studies have demonstrated that cyberbullying behavior has adverse physical and mental health consequences for individuals. However, study on cyberbully behaviour in the context of Malaysia is still limited. In fact tertiary students remain an understudied population regarding cyberbullying. Tertiary students are an important population due to the fact that this phase of age forms habits that persist into young adulthood which consequently shape the community in future. Thus, the aims of this study is to determine the relationship between netiquette, loneliness and emotional availability of parents and cyberbullying behavior. Based on the findings, it was found that only netiquette has a negative significant relationship with cyberbullying behavior. This study is significant to the Ministry of Education, instititutions of higher learning education and community on identifying the factors and subsequently creating awareness programs in dealing with cyberbullying behaviours.
Knowledge and Attitudes of Academicians Towards Organ Donation: A Concept Paper
Authors: Ali Husin Liatul Izian , Mohamad Mozie Noorizan , Ghazali Norfazlina , Azizam Nor Azmaniza 
Published: March 2021

The purpose of this paper is to examine the contributing factors towards the intention to become an organ donor. The literature reviews on the main issues about the awareness of public about organ donation. In Malaysia only 420,601 pledgers of organ donation which is equivalent to 1.3 percent of the total population of Malaysia. This figures in not sufficient to meet the demand from patients in the organ waiting list. Literature reported that the level of awareness in Malaysia is still low. Low organ donation rates have been linked to a lack of public awareness and knowledge about organ donation. In order to get a better insight of what factors that may contribute to the intention of a person to become an organ donor, this paper, based on the past literature propose two factors: Knowledge and attitude as the predictor variables towards intention. The study intends to collect data from the academician in the Universiti Teknologi MARA, Selangor.
The effect of financial liberalization towards financial stability of Islamic banks in Malaysia
Authors: Muhamad arifin Nur Afizah , Mohd Arifin Noraini , Ramly Zulkufly , Mohd Hashim Maryam Jameelah , Abdul Aziz Nor Farradila , Kamaralzaman Surianor 
Published: March 2021

Financial liberalization will affect the stability of the financial system due to excessive risk. Liberalization effort in Islamic banks players raises the issues of the ability of how Islamic banks can survive in the financial liberalization regime. Financial liberalization induced competition and thus impact on financial stability due to excessive risk taking. Malaysia is operating in dual financial system, the effect of mediating roles of competition and interest rate between financial liberalization is expected to be vary at some extend due to shariah constraint. This paper aims to analyze the effect financial liberalization and financial stability. Structural equation model – Partial least square (PLS-SEM) is used to analyze the research model with a comprehensive data set covering the Islamic banks over 1994 -2017. The empirical results denote a significant negative impact of financial liberalization on Islamic banks' financial stability in Malaysia. Lastly, it can be concluded that this study has an implication for policymakers and the banking industry
Financial liberalization will affect the stability of the financial system due to excessive risk. Liberalization effort in Islamic banks players raises the issues of the ability of how Islamic banks can survive in the financial liberalization regime. Financial liberalization induced competition and thus impact on financial stability due to excessive risk taking. Malaysia is operating in dual financial system, the effect of mediating roles of competition and interest rate between financial liberalization is expected to be vary at some extend due to shariah constraint. This paper aims to analyze the effect financial liberalization and financial stability. Structural equation model – Partial least square (PLS-SEM) is used to analyze the research model with a comprehensive data set covering the Islamic banks over 1994 -2017. The empirical results denote a significant negative impact of financial liberalization on Islamic banks' financial stability in Malaysia. Lastly, it can be concluded that this study has an implication for policymakers and the banking industry
Application of normative frameworks for assessing availability of socio-economic policies based on maqasid al shari’a principles in Muslim countries: A proposal
Authors: Abubakar Mustapha , Ringim Kabiru Jinjiri 
Published: March 2021

The objective of this paper is to propose a framework that will assess the availability of maqasid al shari’a based socio-economic policies in Muslim countries, and whose nebulous institutions are perturbed by the statistic that 504 million people are living in multi-dimensional poverty, suffering from range of deprivations in forty-three member countries of the Islamic Development Bank (IDB). Lack of or weak access to adequate resources remain the primary issues faced by many nations. In the midst of this though, there is a recurring argument that the level of socio economic development of human well-being must be improved. To understand development challenges of socio-economic framing in the current Muslim world, factors such as education, health, spirituality, lives and property, economy, food security as well as youth employment as based on maqasid al shari’ah framework model merit consideration. Accordingly, this paper seeks to address the gap in the current literature by incorporating education and youth unemployment factors into the socio-economic development model which is based on maqasid al sharia’h framework. The study adapted the principles of Islamic divine law that ensures an inclusive socio-economic development policy devoid of tribal, ethnic or religious sentiments. The study offered recommendations for further research on maqasid al sharia’ah applications on the socio-economic development of both Muslim and Muslim-minority countries.
Implementasi Kebijakan Layanan Pengaduan Masyarakat Secara Online di Dinas Komunikasi dan Informatika Kota Pontianak
Authors: Dovvi Dovvi 
Published: March 2021

AbstractThis research entitled The Implementation of Online Public Complaint Service at the Communication and Informatics Office Pontianak City analyzed based on the theory put forward by Edward III. This Research is a type of descriptive from interviews with informants and secondary data obtained from various official documents related to research.The Implementation of Online Public Complaint Service at the Communication and Informatics Office Pontianak City has not been able to run effective due to several factors, namely: 1. Communication, 2 Resource, 3. Disposition, 4. Bureaucratic Structure.Based on these problems, the author can make suggestions, namely: 1. 1. There needs to be an affirmation in the form of rules issued by the regional head, namely the Mayor's regulation, 2. Increase the capacity of the implementers both in quality, 3. Focus on public complaint services and support centralized services in Dinas, Communications and, Informatics, Pontianak City. Key words : The Implementation Policy, Public Complaint Service.
Unusual Aggregation Properties of Single Amino Acid L-Lysine Hydrochloride
Authors: Koshti Bharti , Singh Ramesh , Kshtriya Vivekshinh , Walia Shanka , Bhatia Dhiraj , Joshi Khashti Ballabh , Gour Nidhi 
Published: March 2021

.The self-assembly of single amino acids is very important topic of research since there are plethora of diseases like phenylketonuria, tyrosinemia, hypertryptophanemia, hyperglycinemia, cystinuria and maple syrup urine disease to name a few which are caused by the accumulation or excess of amino acids. These are in-born errors of metabolisms (IEM’s) which are caused due to the deficiency of enzymes involved in catabolic pathways of these enzymes. Hence, it is very pertinent to understand the fate of these excess amino acids in the body and their self-assembling behaviour at molecular level. From the previous literature reports it may be surmised that the single amino acids like Phenylalanine, Tyrosine, Tryptophan, Cysteine and Methionine assemble to amyloid like structures, and hence have important implications in the pathophysiology of IEM’s like phenylketonuria, tyrosinemia, hypertryptophanemia, cystinuria and hypermethioninemia respectively. In this manuscript we report the self-assembly of lysine hydrocholride to fiber like structures in deionized water. It could be observed that lysine assemble to globular structures in fresh condition and then gradually changes to fiber like morphologies by self-association over time after 24 hours. These fibers gradually change to tubular morphologies after 3 day followed by fractal irregular morphologies in 10 and 15 days respectively. Notably, lysine exists as positively charged amino acid at physiological pH and the amine groups in lysine remain protonated. Hence, the self-assembling properties of lysine hydrochloride in deionized water is also pertinent and give insights into the fate of this amino acid in body in case it remains unmetabolized. Further, MTT assays were done to analyse the toxicities of these aggregates and the assay suggest their cytotoxic nature on SHSY5Y neural cell lines. Hence, the aggregation of lysine may be attributed to the pathological symptoms caused in diseases like hyperlysinemia which is associated with the neurological problems like seizures and short-term memory as observed in case of amyloid diseases like Parkinson’s and Alzheimer’s to name a few.
Pengaruh Motivasi Kerja, Gaya Kepemimpinan Dan Kompensasi Terhadap Kinerja Karyawan Pada Perusahaan Konstruksi PT. Pundikarya Sejahtera Bekasi
Authors: Setiyono Setiyono 
Published: March 2021

AbstractThis research takes object at PT. Pundikarya Sejahtera Bekasi City, aims to determine the influence of motivation, leadership style, compensation on employee performance at PT. Pundikarya Sejahtera Kota Bekasi and which variable is the most dominant effect on employee performance. Data were collected through questionnaires involving 52 employees as both population and sample. Data analysis using SPSS program with data analysis technique using multiple linier regression analysis. The results showed that motivation and compensation have a significant effect on employee performance, while leadership style has no significant effect on employee performance, and the compensation variable is the most dominant influence to employee performance.Keywords: motivation, leadership style, compensation and employee performance AbstrakPenelitian ini mengambil objek di PT. Pundikarya Sejahtera Kota Bekasi ini bertujuan untuk mengetahui pengaruh motivasi, gaya kepemimpinan, kompensasi terhadap kinerja karyawan pada kontraktor bangunan PT. Pundikarya Sejahtera Kota Bekasi serta variabel manakah yang paling dominan berpengaruh terhadap kinerja karyawan. Data dikumpulkan melalui kuesioner yang melibatkan 52 karyawan sebagai populasi sekaligus sampelnya. Analisis data menggunakan program SPSS dengan teknik analisa data menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa motivasi dan kompensasi berpengaruh signifikan terhadap kinerja karyawan, sedangkan gaya kepemimpinan tidak berpengaruh signifikan terhadap kinerja karyawan, dan variabel kompensasi adalah yang paling dominan berpengaruh terhadap kinerja karyawan.Kata kunci: motivasi, gaya kepemimpinan, kompensasi dan kinerja karyawan
PENGARUH MODEL PEMBELAJARAN (CC) BERBASIS SCAFFOLDING TERHADAP KEMAMPUAN SCIENTIFIC REASONING FISIKA SISWA SMA
Authors: Azmi Devi Tri Ulul , Astutik Sri , Subiki Subiki 
Published: March 2021

The purpose of the research is conducted to examine the effect of Scaffolding-based (CC) learning models on the ability of scientific reasoning physics of high school students. The research population was MAN Bondowoso 2019/2020 students and the research sample was the students of class XI IPA 1 and XI IPA 2. The research techniques used were observation, tests and documentation. There are two stages of data analysis technique, they are normality test and independent sample t-test using SPSS version 23. The result shows that the experimental class and control class data are normally distributed, that is the sig value. > 0.05. Independent test sample t-test using SPSS 23 on the scientific reasoningphysics capability obtained sig. (2-tailed) by 0,038 and the result of sig. (1-tailed) for 0,019 meaning that the test is <0.05. The results showed that the model based on Scaffolding had a significant effect on the ability of scientific reasoning physics of high school students of high school students.
Effectivity of Scientific Approach Oriented Learning in Heredity toward Senior High School Students’s Scientific Creativity
Authors: Inayah Nailil , Hidayat M Thamrin , Nur Mohammad 
Published: March 2021

The purpose of this research was to investigate the effect of scientific approach oriented learning toward senior high school student’s scientific creativity. This learning was conducted in XII grade of SMA Muhammadiyah 2 Surabaya by using one-group pretest-posttest design. The methods of data collection were using observation, tests, and questionnaires. Data was analyzed using descriptive analysis quantitatively and qualitatively. The results showed that the learning is effective to enhance scientific creativity students based on N-gain and was significant stated through paired sample t-test. Then implementation of learning got student’s positive response. Overall, it can be concluded that scientific approach oriented learning was effective to train senior high school student’s scientific creativity.
Resenha de: Ratuva, Steven, Radomir Compel, e Sergio Aguilar, 2019 (Orgs). Guns & Roses: Comparative Civil-Military Relations in the Changing Security Environment. Singapore: Springer Singapore.
Authors: Dos Santos Tamiris Pereira 
Published: March 2021

Resenha da obra Guns & Roses: Comparative Civil-Military Relations in the Changing Security Environment, lançada em 2019, com o objetivo de compilar as contribuições diversas trazidas ao longo da compilação em seu caráter panorâmico e de atualização das discussões sobre relações civil-militares no mundo.
Suplemen Jus Daun Afrika (Vernonia amygdalina) dalam Air Minum terhadap Komposisi Kimia dan Kadar Malondialdehid Telur Puyuh (Coturnix coturnix japonica)
Authors: Hasbullah Innaka , Wulandari Z , Suci D M 
Published: March 2021

This study aimed to determine the effectiveness of African leaf juice supplements on the chemical properties of quail eggs. This research used 120 quails aged 8 weeks, which divided into 3 treatments and 5 replications. The experimental design used a completely randomized and the treatments were P0 : without the supplementation of African leaf juice as controls, P1: addition of 3 ml head-1 day-1 African leaf juice, and P2: addition of 6 ml head-1 day-1 African leaf juice (P2). The variables observed were moisture, ash, crude protein, ether extract, carbohydrate, malondialdehyde content (MDA), pH and water activity (Aw) in yolk and albumen. The results showed that moisture, ash, crude protein, ether extract, and carbohydrate content in egg yolks had no different effect compared to controls. Malondialdehid (MDA) content in the treatment of 3 ml head-1 day-1 and 6 ml head-1 day-1 of African leaf juice supplementation decreased 39.68% and 36.19% compared to control. Aw level in yolk and albumen significantly (p<0.05) decreased in 6 ml of African leaf juice supplementation, but no effect on the pH eggyolk and albumen. It was concluded that addition of 3 ml and 6 ml of African leaf juice head-1 day-1 could reduce the MDA content of egg yolk.
Effectiveness of Metabolite Substance Filtrates of Actinomycetes isolates from Kebun Raya Bogor against the growth of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi: In Vitro study
Authors: Tsani Ariandi Muhammad Zaidan , Bahar Meiskha , Yusmaini Hany , Zulfa Fajriati , Fauziah Cut , Pramesyanti Andri 
Published: March 2021

Actinomycetes are found in soils with loose, humus, dry characteristics and around plant roots. Actinomycetes produce secondary metabolite compounds as antibacterial. Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi are Gram negative bacteria that can cause infection in humans. This study aims to determine the ability of the Actinomycetes metabolite filtrate from Bogor Botanical Gardens as an antibacterial agent against the growth of E. coli, P.aeruginosa and S. typhi in vitro. This study used an experimental design with samples of Actinomycetes isolats originating from the Bogor Botanical Gardens soil using the disc diffusion method on Muller Hinton Agar (MHA) media by looking at the clear zone of bacterial growth around the disc paper. Of the three concentration groups, namely 50%, 60%, and 70%, the largest average inhibition zone is found at a concentration of 70% with the average for the three test bacteria E. coli, P.aeruginosa and S. typhi respectively: 4.23 mm; 3.0 mm and 8.43 mm. The results of the Kruskal - Wallis test with p value = 0.01 showed that there was an effect of the Actinomycetes metabolite filtrate on the growth of the three tested bacteria as antibacterials.ÃÂ ÃÂ
PENGEMBANGAN LUMBUNG PAKAN PADA KELOMPOK TANI-TERNAK KERBAU SUMBAWA UNTUK PENINGKATAN PRODUKSI DAN PENDAPATAN PETERNAK DI DESA GAPIT, KECAMATAN EMPANG, KABUPATEN SUMBAWA
Authors: Suhubdy Suhubdy , Soekardono Soekardono , Fachry Anwar , Hasan Sofyan D. 
Published: March 2021

Desa Gapit adalah salah satu desa di Kecmatan Empang Kabupaten Sumbawa yang telah memiliki kelompok tani-ternak kerbau, yaitu kelompok “ABADI JAYA”. Namun, kelompok tersebut belum berfungsi optimal sebagai wahana pengembangan usaha ternak kerbau. Para peternak masih memelihara ternak secara tradisional sehingga produksi dan produktivitas ternak masih rendah. Melalui pengabdian kepada masyarakat ini diharapkan kelompok tani-ternak tersebut dapat lebih maju dan mandiri. Tujuan pengabdian kepada masyarakat ini adalah, (1) untuk meningkatkan kemampuan manajemen sistem produksi ternak kerbau berbasis kelompok, dan (2) untuk memperbaiki sistem manajemen kelompok dan manajemen usaha. Pengabdian ini dilakukan pada kelompok tani-ternak “ABADI JAYA” di desa Gapit, Kecamatan Empang, Kabupaten Sumbawa. Kegiatan dalam pengabdian ini meliputi penyuluhan dan pelatihan kepada pengurus dan anggota kelompok tani-ternak sebanyak 20 orang yang dilaksanakan dalam dua kali pertemuan dalam dua bulan. Pertemuan pertama, memberikan motivasi dan penjelasan tentang sistem produksi ternak kerbau yang baik dengan penerapan panca usaha ternak kepada seluruh peternak anggota kelompok agar para peternak menyadari bahwa usaha ternak kerbau dapat menjadi sumber pendapatan utama bagi peternak. Pertemuan kedua, memberikan penyuluhan tentang manajemen usaha dan manajemen kelompok, meliputi bagaimana merencanakan usaha, kalkulasi biaya dan pendapatan, dan pemasaran ternak. Hasil pengabdian ini menunjukkan bahwa para peternak kerbau sangat termotivasi untuk mengembangkan usaha ternak kerbaunya dengan memajukan kelompok teni-ternaknya. Mereka mulai menyadari pengelolaan dengan menggunakan teknologi, terutama teknologi pakan sangat penting. Mereka menyatakan sanggup mengadakan lumbung pakan untuk mengatasi krisis pakan musim kemarau. Mereka juga menyatakan kesanggupannya untuk memajukan kelompok menjadi kelompok yang berorientasi bisnis