bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aeromonas sobria Induces Proinflammatory Cytokines Production in Mouse Macrophages via Activating NLRP3 Inflammasome Signaling Pathways
Authors: Zhang Wei , Li Zhixing , Yang Haitao , Wang Guanglu , Liu Gang , Wang Yu , Bello Babatunde Kazeem , Zhao Panpan , Liang Wei , Dong Jingquan 
Published: August 2021

Aeromonas sobria, a common conditional pathogenic bacteria, is widely distributed in the environment and causes gastroenteritis in humans or septicemia in fish. Of all Aeromonas species, A. sobria is the most frequently isolated from human infections especially in immunocompromised subjects. Innate immunity is the first protection system of organism to resist non-specific pathogens invasion; however, the immune response process of hosts against A. sobria infection re\mains unexplored. The present study established an A. sobria infection model using primary mouse peritoneal macrophages (PMφs). The adherence and cytotoxicity of A. sobria on PMφs were determined by May-Grünwald Giemsa staining and LDH release measurement. Pro-inflammatory cytokine expression levels were measured using qPCR, western blotting, and ELISA methods. We also investigated the levels of ASC oligomerization and determined the roles of active caspase-1 in IL-1β secretion through inhibition assays and explored the activated pattern recognition receptors through immunofluorescence. We further elucidated the roles of activated inflammasome in regulating the host’s inflammatory response through inhibition combined with ELISA assays. Our results showed that A. sobria induced lytic cell death and LDH release, whereas it had no adhesive properties on PMφs. A. sobria triggered various proinflammatory cytokine transcription level upregulation, and IL-1β occupied the highest levels. The pro-IL-1β protein expression levels increased in a dose-dependent manner with MOI ranging from 1 to 100. This process was regulated by ASC-dependent inflammasome, which cleavage pro-IL-1β into active IL-1β p17 with activated caspase-1 p20. Meanwhile, the expression levels of NLRP3 receptor significantly increased, location analysis revealed puncta-like surrounding nuclear, and inhibition of NLRP3 inflammasome downregulated caspase-1 activation and IL-1β secretion. Blocking of NLRP3 inflammasome activation through K+ efflux and cathepsin B or caspase approaches downregulated A. sobria–induced proinflammatory cytokine production. Overall, these data indicated that A. sobria induced proinflammatory cytokine production in PMφs through activating NLRP3 inflammasome signaling pathways.
Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and In Vitro Experimental Verification
Authors: Huang Shi , Chen Yan , Pan Lingyu , Fei Changyi , Wang Ni , Chu Furui , Peng Daiyin , Duan Xianchun , Wang Yongzhong 
Published: August 2021

BackgroundTao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects.ObjectivesTo explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research.MethodsThe active ingredients of THSWD were screened according to Lipinski’s rule of five based on the 107 ingredients of THSWD identified by UPLC-Q-TOF-MSE. The targets of THSWD and breast cancer from multiple databases were collected, and a Compound-Target-Pathway network based on protein-protein interaction (PPI) was constructed. Gene ontology (GO) analysis and KEGG pathway analysis were performed via the DAVID server. Molecular docking studies verified the selected key ingredients and key targets. The results of network pharmacology were verified by in vitro experiments. Including the effects of THSWD drug-containing rat serum (THSWD serum) on cell proliferation, and on the targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 were assayed by RT-qPCR and Western blot assays.ResultsIn total, 27 active ingredients including 8 core components, were obtained from 107 ingredients and 218 THSWD target genes for the treatment of breast cancer were identified. THSWD is active in the treatment of breast cancer by targeting Ras, FoxO, PI3K-Akt and other signaling pathways. MCF-7 and MDA-MB-231 cell proliferation was inhibited by THSWD serum in a time and concentration dependent manner. THSWD could regulated the RNA and protein expression of core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 for treatment of breast cancer.ConclusionThe results of network pharmacology study showed that THSWD is active against breast cancer by intervening with multiple targets and pathways. Luteolin, kaempferol, senkyunolide E, and other 8 compounds may be the core active ingredients of THSWD in the treatment of breast cancer. THSWD treatment of breast cancer may be related to targeting Ras, FoxO, PI3K-Akt, and other signal pathways associated with the core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14.
Covid-19 Pandemic Impact on World Economy
Authors: Zahoor Zunaira 
Published: August 2021

This study is being conducted when the Corona virus spreads around the world and becomes an economic major crisis in 2020. Researchers explain the impact of the Corona virus on the world economy by getting information from Standard & poverty agencies (S&P), Organization of Economic Cooperation and Development (OECD), and from different websites and reports. moreover, researchers obtain information from the International Monetary Fund (IMF). In addition, Explain the losses from one industry to another and concluded that the global economy is confronted by dual crises in nature. The deaths of millions of people are on the one hand and the economy crisis on the other. The first problem comprises saving people from death, and the second in saving the universe against economic crises. But both challenges are inconsistent. If individuals want to preserve lives, a remain at home and a social distance policy are imposed, and the country is shut down. However, we can rescue our citizens living, but the economy collapses fast because all the companies in the country have been shut down. If economic crisis is saved, people are supposed to go out and work as normal, the global economy would boost but soon millions or billions of people are lost who will also have an impact on the economic downturn. Policymakers, doctors and manufacturers of health should work together to identify solutions to benefit both individuals living and saving economic crisis.
Taklim Virtual Muslimah pada Masa Pandemi Covid-19 di Wilayah Provinsi Bangka Belitung
Authors: Sari Hijrayanti , M. Amirullah  , Aswar Aswar 
Published: August 2021

The Covid-19 pandemic presents its own challenges for the implementation of education, research, and community service. Various adaptations are made so that academic activities can continue to run well, not least the implementation of KKN STIBA Makassar in Bangka Belitung Region. Bangka Belitung Island Province is a province in Indonesia consisting of two main islands namely Bangka Island and Belitung Island as well as hundreds of small islands. The purpose of the implementation of virtual community service is intended so that the condition of pandemic covid-19 is not the reason for the unfulperforming of various muslimah education and coaching activities by students of KKN STIBA Makassar in Bangka Belitung region. The various virtual activities carried out for Muslims are: 1) Virtual weekly Taklim Muslimah; 2) Construction of DIROSA; 3) Tahsin and Tahfiz Online; 4) Virtual Arabic Teaching; 5) Learn Islam Intensively Online; and 6) Pre-Ramadan Webinar. Although in the implementation there are obstacles, such as the condition of the network both participants and committees are less supportive, but the obstacles do not reduce the spirit of da'wah KKN IV STIBA Makassar students in Bangka Belitung Region, to be able to produce twenty active mentors who follow various virtual coaching programs during the kkn period is implemented.
La invención del ciudadano en la América Latina de siglo XX:Una mirada a través de la investigación histórica de los manuales de civismo en Colombia y Argentina.
Authors: Cortés Salcedo Ruth Amanda 
Published: August 2021

Las investigaciones sobre la formación de la imagen nacional y la constitución de laciudadanía del siglo XX en los textos escolares, cuentan con una corta pero significativa tradición en América Latina. En conjunto, lo que dejan ver estos trabajos es que esa imagen tiene una estrecha relación con la producción de un tipo ideal de ciudadano que se promociona a través de los manuales de civismo. En este texto intentaremos complejizar un poco esa mirada que, a nuestro modo de ver, ha llevado la discusión a un dilema poco satisfactorio: o bien, se trata de una cuestión de dominación ideológica, o bien sería un asunto de precario cumplimiento práctico de un proyecto teórico.
Ciudadanía, sociedad,cultura, educación
Authors: Londoño Pinzón Jorge Enrique , González Pérez Marcos , Goyes Narváez Julio César 
Published: August 2021

Este artículo se presenta en el marco de la investigación de pedagogía ciudadana que se adelanta en desarrollo del contrato interadministrativo No.120 del 2008, suscrito entre el Instituto para la Investigación Educativa y el Desarrollo Pedagógico (IDEP) y la Universidad Nacional de Colombia (Instituto de Estudios en Comunicación y Cultura, IECO). El texto consta de tres partes, formuladas desde lo social, lo conceptual, lo comunicativo-emotivo y lo educativo, surgidas de los debates realizados internamente por los autores para contribuir a la formulaciónde criterios teóricos, conceptuales y metodológicos en el diseño de rutas pedagógicas para impulsar procesos de aprehensión de cultura ciudadana.
PENGARUH FREKUENSI MENYIKAT GIGI TERHADAP DEBRIS INDEKS PADA SISWA KELAS V DI SD KARTIKA XXI-4 KECAMATAN PAAL DUA KOTA MANADO
Authors: Ni Made Yuliana  , Ratuela Jeineke E 
Published: August 2021

Kesehatan gigi dan mulutsangatpentinguntukselaludijaga, salah satu cara mencegah terjadinya masalah kesehatan gigi dan mulut dapat dilakukan dengan menyikat gigi. Frekuensidan waktumenyikatgigi yang baikyaitu 3 kali seharipagisetelahmakanpagi, siang setelah makan siang dan malam sebelum tidur. Tujuan penelitian ini untuk mengetahui pengaruh frekuensi menyikat gigi terhadap debris indeks pada siswakelas V di SD Kartika XXI-4 Kecamatan Paal Dua Kota Manado. Jenis penelitian ini bersifat analitik dengan pendekatan cross sectional study dengan menggunakan metode total sampling. Frekuensi menyikat gigi diukur menggunakan lembar check-list untuk mengetahui berapa kali responden menyikat gigi dalam sehari, dan debris indeks dilakukan pemeriksaan dengan menggunakan format pemeriksaan debris indeks. Hasil penelitian yang diperoleh kemudian diolah menggunakan analisis uji correlations kendall’s tau. Hasil analisis menggunakan uji correlations kendall’s tau didapatkan nilai sebesar -0,798 dengan kekuatan korelasi kuat dengan nilai psebesar 0,000 lebih kecil dari nilai ? = 0,05 sehingga terdapat nilai korelasi yang bermakna antara variabel frekuensi menyikat gigi dengan variabel debris indeks dengan arah korelasi negatif (-) yang berarti semakin besar nilai frekuensi menyikat gigi maka semakin kecil nilai debris indeks. Sehingga dapat disimpulkan bahwa ada pengaruh frekuensi menyikat gigi terhadap debris indeks.
KONDISI SANITASI DASAR DENGAN KEJADIAN DIARE PADA MASYARAKAT
Authors: Manik Erba Kalto , Tanjung Risnawaty , Ambarita Monika putri 
Published: August 2021

Diarrhea is a health problem that is still often experienced by the community and is a cause of high morbidity and mortality rates. The environmental factors that play a role are basic sanitation conditions which include clean water supply facilities, family latrine facilities, garbage disposal facilities and waste water disposal facilities. The research method used in this study is quantitative analysis using a Cross Sectional Design which aims to determine the condition of basic sanitation facilities. with the incidence of diarrhea in the community. The number of samples used in this study amounted to 65 samples. Data analysis was performed using the chi square test. The results showed that there was a significant relationship between clean water supply facilities and the incidence of diarrhea in the community with p value = 0.000 (p < 0.05), and sewerage facilities (SPAL) with p value = 0.000 (p < 0.05). while not significant are latrine facilities p value (0.702) and waste disposal facilities with the incidence of diarrhea in the community p value = 0.448 (p > 0.05).
GAMBARAN PENGGUNAAN ALAT PERAGA BONEKA JARI DAN TANPA ALAT PERAGA DALAM PENYULUHAN TERHADAP TINGKAT PENGETAHUAN KESEHATANGIGI DAN MULUT SISWA/I KELAS IVSDNEGERI 101832 PANCUR BATUKECAMATAN PANCUR BATU
Authors: Aritonang Netty Jojor , Soahaan Yenny Lisbeth 
Published: August 2021

Health education is one of the health education activities, carried out by spreading a message, instilling confidence with the aim that the community aware, know, understand, and want to do a suggestion related to health. Counseling can be done by the method of storytelling, assisted by finger puppet props. This study aims to determine the level of knowledge of students about oral health through counseling - using and without finger puppets.
This research is a descriptive study with survey method which examines 36 samples. Data is collected through a questionnaire filled out by students, which is then processed using a frequency distribution table
Through the results of the study, the following data are known: the score of knowledge level after counseling without teaching aids is 4 students (22%) in the good category, 14 students (78%) in the medium category, and no students in the bad category; after giving information with finger puppets props changes, 15 students (83%) in the good category, 3 students (17%) in the medium category, and no students in the bad category.
This study concludes that counseling with the use of finger puppets is very effective, characterized by an increase in knowledge through this extension method.
TINGKAT BREASTFEEDING SELF EFFICACY TERHADAP MOTIVASI IBU NIFAS POST-OP SECTIO SECARIA DALAM PEMBERIAN ASI EKSLUSIF DI WILAYAH KERJA PUSKESMAS KEPANJEN MALANG
Authors: Inu Martina  , Janes Jainurakhma  
Published: August 2021

ABSTRAK
Ibu nifas post-op sectio secaria membutuhkan proses penyembuhan yang unik, baik secara fisik maupun psikis, begitu pula dengan breastfeeding self efficacy yang baik mampu meningkatkan kemampuan ibu nifas dalam memberikan ASI eksklusif pada bayi baru lahir. Penelitian ini bertujuan untuk menganalisis tingkat breastfeeding self efficacy ibu nifas post-op sectio secaria terhadap motivasi dalam memberikan ASI eksklusif. Penelitian ini menggunakan pendekatan non eksperimen, dengan 67 responden, dengan menggunakan 24 item pertanyaan yang mengukur motivasi breastfeeding scale dan 14 item Breastfeeding Self Efficacy Scale- SF, dengan analisis regresi linear sederhana. Hasil penelitian menunjukkan korelasi positif, dimana semakin tinggi breastfeeding self efficacy maka semakin tinggi pula motivasi menyusui pada ibu nifas pasca persalinan, dengan nilai significant menunjukkan p-value <0,001. Penelitian ini mengindikasikan bahwa seorang ibu nifas post-op sectio secaria membutuhkan breastfeeding self efficacy yang tinggi untuk meningkatkan motivasi ibu dalam memberikan ASI eksklusif pada bayi baru lahir. Terpenuhinya kebutuhan nutrisi bayi baru lahir lewat ASI yang diberikan oleh ibu, mampu membantu pertumbuhan dan perkembangan bayi dan juga mensupport hubungan emosional ibu dan anak ke arah yang lebih baik.
PENINGKATAN PENYEMBUHAN LUKA KAKI DIABETIK NEUROPATI DENGAN MENGGUNAKAN OFF-LOADING SEDERHANA
Authors: Sukarni  , Djoko Priyono  , Mita  , Junaidi  , Usman  
Published: August 2021

ABSTRAK
Perawatan luka kaki diabetik neuropati membutuhkan waktu yang lama dalam proses penyembuhannya. Perawatan luka yang telah diberikan kurang maksimal karena area luka selalu mengalami tekanan yang mengakibatkan luka menjadi terhambat untuk perbaikan jaringan. Off-loading sederhana merupakan intervensi yang dapat membantu mengurangi tekanan pada area luka. Luka yang tidak terjadi penekanan membantu mempercepat penyembuhan. Tujuan dari penelitian ini adalah untuk mengetahui dan mengevaluasi percepatan penyembuhan pada luka kaki diabetik neuropati dengan menggunakan metode Off-loading sederhana. Jenis penelitian yang digunakan yaitu penelitian eksperimen dengan desain quasi eksperimen. Total sampel 16 sampel tetapi 7 sampel tidak diintervensi karena tidak melakukan kunjungan kembali dan mengalami infeksi berulang. Perawatan luka menggunakan standar perawatan luka Klinik Kitamura yang ditambahkan dengan Off-loading sederhana. Luka dievaluasi setelah 4 minggu pengobatan yang meliputi skor luka (MUNGs) dan ukuran luka. Uji yang digunakan yaitu uji-t berpasangan dan uji Wilcoxon. Hasil Jenis kelamin terbanyak adalah perempuan (88,9%), tidak merokok (88,9%) dan monofilamen sebagian besar tidak normal (55,6%). Usia rata-rata adalah 53,56 tahun, rata-rata GDS 255 mg/dl dan nilai ABI rata-rata 0,95. Uji bivariat Skor luka sebelum dan sesudah intervensi dengan p = 0.05 dan ukuran luka dengan p = 0.11. Penggunaan off-loading sederhana berpengaruh pada percepatan penyembuhan luka kaki diabetik neuropati.
KARAKTERISTIK DAN PERSEPSI IBU BALITA TENTANG PEMANFAATAN BUKU KIA SEBAGAI DETEKSI DINI TUMBUH KEMBANG BALITA DI MASA ADAPTASI TATANAN HIDUP BARU
Authors: Ni Wayan Manik Parwati  , Idah Ayu Wulandari  , Putu Ayu Ratna Darmayanti  
Published: August 2021

ABSTRAK
Tatanan hidup baru selama pandemi COVID-19 juga berdampak pada pelayanan kesehatan untuk balita terutama dalam hal pemantauan deteksi dini tumbuh kembang balita. Pemanfaatan buku KIA sebagai deteksi dini tumbuh kembang balita menjadi hal yang harus diperhatikan. Penelitian ini bertujuan untuk mengetahui karakteristik dan persepsi ibu balita tentang pemanfaatan buku KIA. Penelitian ini merupakan penelitian analitik korelasi dengan pendekatan cross sectional. Jumlah sampel dalam penelitian ini 124 responden di kota Denpasar menggunakan analisis uji Chi Square. Hasil Penelitian menunjukkan karakteristik umur responden paling banyak umur 26-30 tahun (36,3%), jumlah anak 1 (42,8%), pendidikan menengah (52,4%) dan tidak bekerja (33,1%). Sebagian besar responden memiliki persepsi yang positif (77.4%) serta mampu memanfaatkan buku KIA sebagai deteksi dini tumbuh kembang balita dengan baik (74,2%). Terdapat hubungan antara karakteritik umur (p=0,075) jumlah anak (p<0,001), pendidikan (p=0,001) dan persepsi (p=0,02) dengan pemanfaatan buku KIA, sedangkan karakteristik pekerjaan ibu tidak berhubungan dengan pemanfaatan buku KIA sebagai deteksi dini pertumbuhan dan perkembangan (p=0,131). Ibu yang memiliki balita diharapkan menggunakan buku KIA dengan optimal sebagai deteksi dini tumbuh kembang balita agar kedepannya perkembangan anak tidak terhambat.
DEVELOPMENT OF A NATIONAL STANDARD
FOR TESTING METHODS
FOR SELF-COMPACTING CONCRETE MIXTURE
Authors: TITOVA Larisa , BEYLINA Maya , KHLOPUK Vladimir , SHABALIN Vladimir 
Published: August 2021

In world practice, self-compacting concrete is
increasingly used due to its unique properties
and advantages. Self-compacting concrete
mixtures have high ductility, better fluidity,
high density with low water content due to the
use of special effective mineral and chemical
additives that provide high performance for
concrete. The rheological properties of SCC
differ significantly from those of conventional
concrete. In this regard, when designing the
composition of concrete and controlling its
quality in laboratory and production conditions,
several methods for controlling the quality of a
self-compacting concrete mixture were created.
The purpose of this standard was to create
a single regulatory document regulating the
assessment of the quality of a self-compacting
concrete mixture.
Concrete from a self-compacting mixture can
be used for underground and hydrotechnical
construction for the erection of structures of
large length, complex geometric shape and
densely reinforced structures.
CHANGES IN THE CODE OF RULES
FOR THE DESIGN OF STRUCTURES
MADE OF CONCRETE WITH POLYMER
COMPOSITE REINFORCEMENT
Authors: MUKHAMEDIYEV Takhir 
Published: August 2021

The article presents information about the
changes made to the code of rules for the
design of concrete structures reinforced with
polymer composite reinforcement. New rules
for the formation of relative deformations at
the base point of a two-line diagram of concrete
under axial tension, used to calculate
reinforced concrete elements for the second
group of limit states, are described. The rules
for calculating re-reinforced structures of
T-or I-beam cross-sections with a shelf in a
compressed zone by the method of limiting
forces are presented. The rules for taking into
account the inelastic properties of concrete of
the stretched zone when determining the elastic-
plastic moment of resistance for the extreme
stretched fibre of concrete with a rectangular
cross-section and a T-shape with a shelf
located in the compressed zone are clarified.
SOBRE EL ENCUENTRO CON LAS IMÁGENES: UNA MIRADA AFECTIVA A TRAVÉS DE LOS FILMES RECONSTRUCCIÓN (2003), ALLEGRO (2005) Y OFFSCREEN (2006) DEL DIRECTOR DANÉS CHRISTOFFER BOE
Authors: González Romo de Vivar Francisco 
Published: August 2021

En años recientes, las humanidades y las ciencias sociales han experimentado un viraje afectivo (Massumi, 2002b), (Clough y Halley, 2007), (Gregg y Seigworth, 2010). Esta reorientación teórica privilegia a la experiencia y al encuentro como categorías desde las cuales pensar múltiples fenómenos. Este trabajo es una aproximación al cine desde las teorías del afecto; es un recorrido, a través de una multitud de voces, por algunos postulados del evento cinemático. Es también una investigación sobre el alcance de la imagen-afección deleuzeana y un acercamiento afectivo a la trilogía Reconstrucción (2003), Allegro (2005), Offscreen (2006) del director danés Christoffer Boe.