bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case–control study of respiratory medication and co‐occurring gastrointestinal prescription burden among persons with Ehlers–Danlos syndromes
Authors: Bascom Rebecca , Dhingra Radha , Francomano Clair A. , Schubart Jane R. 
Published: November 2021

AbstractWe previously reported increased pain and gastrointestinal (GI) medication prescription claims among persons with Ehlers–Danlos syndromes (EDS) and peripubertal increase in opioid and anti‐emetic claims among women with EDS. Herein, we hypothesized a higher proportion of respiratory and co‐occurring respiratory and GI medication prescription claims among persons with EDS compared to their matched controls with increases among peripubertal women with EDS. We compared the proportions of respiratory and co‐occurring respiratory and GI medication prescription claims among persons with EDS (aged 5–62) against their age‐, sex‐, state of residence‐, and earliest claim date‐matched controls using 10 years of private prescription claims data. Prescription claims among persons with EDS versus matched controls were increased for eight medication classes (p < .0001): intranasal/inhaled corticosteroids (ICS) (30.8% vs. 19.0%), oral steroids (30.0% vs. 16.5%), H1‐antihistamines (26.2% vs. 12.2%), short‐acting beta agonists (22.7% vs. 11.6%), decongestants (21.6% vs. 15.9%), leukotriene modifiers (8.9% vs. 3.6%), ICS/long‐acting beta agonists (5.7% vs. 2.9%), muscarinic antagonists (2.5% vs. 0.9%), and co‐occurring prescriptions (29% vs. 10%). Our results suggest a critical time window for peripubertal intervention and research and a need to focus on the pathogenesis and clinical evaluation of EDS‐specific respiratory and aerodigestive disorders.
Hydrogen Bonds Dominate Brønsted Acid Sites in Zeolite SSZ‐42: A Classification of Their Diversity
Authors: Schroeder Christian , Zones Stacey I. , Hansen Michael Ryan , Koller Hubert 
Published: November 2021

AbstractThe zeolite catalyst SSZ‐42 shows a remarkable high abundance (≈80 %) of hydrogen‐bonded Brønsted acid sites (BAS), which are deshielded from the 1H chemical shift of unperturbed BAS at typically 4 ppm. This is due to their interaction with neighboring oxygen atoms in the zeolite framework when oxygen alignments are suitable. The classification and diversity of hydrogen bonding is assessed by DFT calculations, showing that oval‐shaped 6‐rings and 5‐rings allow for a stronger hydrogen bond to oxygen atoms on the opposite ring side, yielding higher experimental chemical shifts (δ (1H)=6.4 ppm), than circular 6‐rings (δ(1H)=5.2 ppm). Cage‐like structures and intra‐tetrahedral interactions can also form hydrogen bonds. The alignment of oxygen atoms is expected to impact their role in the stabilization of intermediates in catalytic reactions, such as surface alkoxy groups and possibly transition states.
Converting waste polystyrene foam into new value‐added materials: A large‐capacity scavenger to remove cationic dyes and heavy metals
Authors: Ye Hao , Xie Zhengfeng , Li Wei , Pu Yanghao , Liu Minyao , Wen Yiping , Liu Yucheng 
Published: November 2021

AbstractWaste white foam, toxic dyes, and metal ions are difficult to degrade in the ecological environment, posing a serious threat to human health and natural beauty, it is of great significance to design a functional material to jointly solve these problems. This study provided a facile approach to convert waste polystyrene foam into a new acid anhydride modified polystyrene adsorbent (PS‐MA) for the dyes and heavy metals removal from aqueous solution. The as‐obtained absorbent was characterized by Fourier transform infrared spectroscopy, thermogravimetry, scanning electron microscopy, energy dispersive spectroscopy, Brunauer Emmett Teller method, and X‐ray photoelectron spectroscopy. Influencing factors are including, pH, dye concentration, contact time and temperature on the adsorption of methylene blue (MB), safranine T (ST), and Cu(II) were systematically studied. Boehm titration showed that the content of surface carboxyl groups reached 4.53 mmol/g. The maximum adsorption capacity had reached 1405.37 mg/g for MB, 2269.33 mg/g for ST, 65.03 mg/g for Cu(II). Moreover, the kinetic data were in good agreement with the pseudo‐second‐order model and closed to adsorption equilibrium at 20 min. After five times of recycling experiments and the application of mixed dye wastewater with salinity, PS‐MA showed excellent stability and removal ability. Abundant efforts revealed a broad application prospect of PS‐MA materials in water remediation.
Characterizing X‐ray activity cycles of young solar‐like stars with solar observations
Authors: Coffaro Martina , Stelzer Beate , Orlando Salvatore 
Published: November 2021

AbstractThroughout an activity cycle, magnetic structures rise to the stellar surface, evolve, and decay. Tracing their evolution on a stellar corona allows us to characterize the X‐ray cycles. However, directly mapping magnetic structures is feasible only for the Sun, while such structures are spatially unresolved with present‐day X‐ray instruments on stellar coronae. We present here a new method, implemented by us, that indirectly reproduces the stellar X‐ray spectrum and its variability with solar magnetic structures. The technique converts solar corona observations into a format identical to that of stellar X‐ray observations and, specifically, spectra of the X‐ray satellite XMM‐Newton. From matching these synthetic spectra with those observed for a star of interest, a fractional surface coverage with solar magnetic structures can be associated to each X‐ray observation. We apply this method to two young solar‐like stars: Eri ( Myr), the youngest star to display a coronal cycle ( yr), and Kepler 63 ( Myr), for which the X‐ray monitoring did not reveal a cyclic variability. We found that even during the cycle minimum a large portion of Eri's corona is covered with active structures. Therefore, there is little space for additional magnetic regions during the maximum, explaining the small observed cycle amplitude () in terms of the X‐ray luminosity. Kepler 63 displays an even higher coverage with magnetic structure than the corona of Eri. This supports the hypothesis that for stars younger than Myr the X‐ray cycles are inhibited by a massive presence of coronal regions.
Beneficial effects of PEGylated graphene quantum dot on arrhythmias induced by myocardial infarction
Authors: Rostamzadeh Farzaneh , Najafipour Hamid , Jafarinejad‐Farsangi Saeideh , Ansari‐Asl Zeinab 
Published: November 2021

AbstractArrhythmias are one of the leading causes of early death following myocardial infarction (MI) and heart failure. Graphene derivatives have emerged as an therapeutic target that have electrical conductivity. The study aimed to evaluate the impacts of polyethylene glycol–graphene quantum dots (GQDs‐PEG) on arrhythmias created by MI in the rat. Animals were randomly assigned to five groups of sham, MI, and MI + GQDs‐PEG at doses of 5, 10, and 20 mg/kg. MI was induced by the closure of the left anterior descending artery. The day after MI, animals were administered vehicle (phosphate buffered saline) or GQDs‐PEG at different doses every other day for 2 weeks. On day 15, electrocardiogram (ECG), mean arterial pressure (MAP), and heart contractility indices were recorded by the PowerLab data acquisition system. GQDs‐PEG 20 mg/kg increased contractility and improved the reduction of MAP in the MI group. The prolonged QT and QTc intervals, inverted T wave, and deviated ST segment were modified by GQDs‐PEG 10 and 20 mg/kg in rats with MI. The amplitude of the Q wave was also decreased in a dose‐dependent manner in the GQDs‐PEG–treated rats. The results demonstrated that 2 weeks of treatment with GQDs‐PEG normalized ECG abnormalities and improved left ventricular dysfunction in rats with MI.