bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: About a Case of Hyperammonemia Syndrome Following Lung Transplantation: Could Metagenomic Next-Generation Sequencing Improve the Clinical Management?
Authors: Michel Charlotte , Raimo Michela , Lazarevic Vladimir , Gaïa Nadia , Leduc Nina , Knoop Christiane , Hallin Marie , Vandenberg Olivier , Schrenzel Jacques , Grimaldi David , Hites Maya 
Published: July 2021

Background:Mycoplasma hominis and Ureaplasma spp. are responsible for opportunistic infections in transplant patients, sometimes causing a life-threatening hyperammonemia syndrome. Both pathogens are not identified with standard microbiology techniques, resulting in missed or delayed diagnosis. We present a clinical case that illustrates the added value that next-generation sequencing (NGS) may offer in the diagnosis of respiratory infections in immune-compromised patients.Results: A 55 years-old man with idiopathic pulmonary fibrosis underwent double lung transplantation. He received antibiotic prophylaxis with piperacillin-tazobactam and azythromycin. At day 4 post-transplantation (PTx), the patient presented an acute respiratory distress. A broncho-alveolar lavage (BAL) was performed. At day 5 PTx, the patient presented a status epilepticus due to diffuse cerebral oedema. Serum ammonia concentration was 661 μg/dL. BAL bacterial culture was negative. Because of the clinical presentation, special cultures were performed and identified 100.000 CFU/mL of M. hominis and Ureaplasma spp. and specific PCRs were positive for M. hominis and Ureaplasma parvum. Antibiotic therapy was shifted to therapeutic dose of azithromycin and doxycycline; within 48 h ammonia serum concentrations returned to normal but the coma persisted several weeks, followed by a persistent frontal lobe syndrome. A follow-up BAL was performed on day 11 Ptx. The Mycoplasma/Ureaplasma culture was negative, yet the specific PCRs remained positive. Bacterial culture found 100 CFU/mL of Staphylococcus aureus and viral culture was positive for Herpes Simplex Virus-1. These results were confirmed by metagenomic next-generation sequencing (mNGS). In the bacterial fraction, the majority of reads belonged to Corynebacterium propinquum (34.7%), S. aureus (24.1%) and Staphylococcus epidermidis (17.1%). Reads assigned to M. hominis, Ureaplasma urealyticum and parvum represented 0.71, 0.13, and 0.04% of the bacterial fraction and corresponded to 6.9 × 103, 9.7 × 102, and 3.7 × 102 genome equivalents per mL of BAL fluid, respectively. These results are in favor of a cure of the atypical infection.Conclusions: mNGS offered added diagnostic and quantitative values compared to PCR tests, which can remain positive after resolved infections. The initiation of appropriate antibiotic therapy would have occurred earlier on, possibly resulting in a better clinical outcome if mNGS had been performed in a routine fashion.
A Systematic Review of the Predictive Value of Plasma D-Dimer Levels for Predicting Stroke Outcome
Authors: Zhang Peng , Wang Chun , Wu Junhua , Zhang Shiliang 
Published: July 2021

Background: Stroke is a leading cause of morbidity and mortality. Over the past decade, plasma D-dimer levels have emerged as a biomarker for predicting stroke outcome. However, no consensus in the literature currently exists concerning its utility for predicting post-stroke functional outcome and mortality.Objective: To systematically review the effectiveness of plasma D-dimer levels for predicting functional outcome and mortality following stroke.Methods: Five academic databases were screened according to PRISMA guidelines for eligible studies. With these studies, we conducted a random-effect meta-analysis to evaluate the impact of plasma D-dimer levels for predicting functional outcome and mortality post-stroke. We also conducted subgroup analyses to evaluate differences in predictive capacity for different stroke subtypes.Results: Nineteen studies were included, containing data on 5,781 stroke patients (mean age: 65.26 ± 6.4 years). Overall methodological quality for the included studies was high. Meta-analysis showed that increased D-dimer levels were predictive of worsened functional outcomes (Hazard ratio: 2.19, 95% CI: 1.63–2.93) and elevated overall mortality (2.29, 1.35–3.88). Subgroup analysis showed that plasma D-dimer levels were more predictive of poorer functional outcomes for ischemic (2.08, 1.36–3.18) stroke as compared to intracerebral hemorrhage (2.62, 1.65–4.17). We also noted that predictive capacity was similar when it came to mortality in patients with cryptogenic ischemic stroke (2.65, 0.87–8.08) and intracerebral hemorrhage (2.63, 1.50–4.59).Conclusion: The study provides preliminary evidence concerning the capacity of plasma D-dimer levels for predicting functional outcomes and mortality following stroke and reports that higher D-dimer levels of are associated with poorer functional outcomes and higher mortality.
DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis
Authors: Dutheil Frédéric , de Saint Vincent Sarah , Pereira Bruno , Schmidt Jeannot , Moustafa Farès , Charkhabi Morteza , Bouillon-Minois Jean-Baptiste , Clinchamps Maëlys 
Published: July 2021

Background: Psychosocial stress is a significant public health problem inducing consequences for quality of life. Results about the use of dehydroepiandrosterone (DHEA) as a biomarker of acute stress are conflicting. We conducted a systematic review and meta-analysis to demonstrate that DHEA levels could be a biomarker of stress.Methods: PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched on March 19, 2021 using the keywords “acute stress” AND “DHEA” OR “Dehydroepiandrosterone.” Articles needed to describe our primary outcome, i.e., induction of acute stress and at least two measures of DHEA.Results: We included 14 studies, with a total of 631 participants, in our meta-analysis. The DHEA levels increased overtime after acute stress [standardized mean difference (SMD) = 1.56, 95%CI = 1.13–1.99]. Stratification by time showed a main peak at the end of stress (SMD = 2.43, 95%CI = 1.59–3.27), followed by a progressive decrease (coefficient = −0.11, 95%CI = −0.19 to −0.17, p = 0.020). There was no significant change 1 h after the end of acute stress. Metaregressions showed an impact of mental stress (SMD = 2.04, 95%CI = 1.43–2.65), sex (SMD = 0.02, 95%CI = 0.00–0.04), age (SMD = −0.12, 95%CI = −0.2 to −0.05), and obesity (SMD = 0.31, 95%CI = −0.00 to 0.63). There was no difference whatever the type of fluid (blood or saliva) and the measurement technique used.Conclusions: DHEA is a biomarker of acute stress, with a short-term increase (1 h). DHEA increases following acute mental stress, whatever the type and duration of mental stress. Women, young people, and obese individuals had a higher response. Blood and saliva measures were comparable.
HMD-Based Virtual and Augmented Reality in Medical Education: A Systematic Review
Authors: Xu Xuanhui , Mangina Eleni , Campbell Abraham G. 
Published: July 2021

Background: Virtual Reality (VR) and Augmented Reality (AR) technologies provide a novel experiential learning environment that can revolutionize medical education. These technologies have limitless potential as they provide in effect an infinite number of anatomical models to aid in foundational medical education. The 3D teaching models used within these environments are generated from medical data such as magnetic resonance imaging (MRI) or computed tomography (CT), which can be dissected and regenerated without limitations.Methods: A systematic review was carried out for existing articles until February 11, 2020, in EMBASE, PubMed, Scopus, ProQuest, Cochrane Reviews, CNKI, and OneSearch (University College Dublin Library) using the following search terms: (Virtual Reality OR Augmented Reality OR mixed reality) AND [“head-mounted” OR “face-mounted” OR “helmet-mounted” OR “head-worn” OR oculus OR vive OR HTC OR hololens OR “smart glasses” OR headset AND (training OR teaching OR education)] AND (anatomy OR anatomical OR medicine OR medical OR clinic OR clinical OR surgery OR surgeon OR surgical) AND (trial OR experiment OR study OR randomized OR randomised OR controlled OR control) NOT (rehabilitation OR recovery OR treatment) NOT (“systematic review” OR “review of literature” OR “literature review”). PRISMA guidelines were adhered to in reporting the results. All studies that examined people who are or were medical-related (novel or expert users) were included.Result: The electronic searches generated a total of 1,241 studies. After removing duplicates, 848 remained. Of those, 801 studies were excluded because the studies did not meet the criteria after reviewing the abstract. The full text of the remaining 47 studies was reviewed. After applying inclusion criteria and exclusion criteria, a total of 17 studies (1,050 participants) were identified for inclusion in the review.Conclusion: The systematic review provides the current state of the art on head-mounted device applications in medical education. Moreover, the study discusses trends toward the future and directions for further research in head-mounted VR and AR for medical education.
Oral Immunization with Lactobacillus casei Expressing the Porcine Circovirus Type 2 Cap and LTB Induces Mucosal and Systemic Antibody Responses in Mice
Authors: Li Fengsai , Wang Xiaona , Ma Rumeng , Wu Wei , Teng Fei , Cheng Xi , Jiang Yanping , Zhou Han , Wang Li , Tang Lijie , Qiao Xinyuan , Li Yijing 
Published: July 2021

Porcine circovirus type 2 (PCV2) causes many diseases in weaned piglets, leading to serious economic losses to the pig industry. This study investigated the immune response following oral administration of Lactobacillus casei ATCC393 (L. casei 393) expressing PCV2 capsid protein (Cap) fusion with the Escherichia coli heat-labile toxin B subunit (LTB) in mice. Recombinant L. casei strains were constructed using plasmids pPG611.1 and pPG612.1. The expression and localization of proteins from recombinant pPG611.1-Cap-LTB (pPG-1-Cap-LTB)/L. casei 393 and pPG612.1-Cap-LTB (pPG-2-Cap-LTB)/L. casei 393 were detected. All recombinant strains were found to be immunogenic by oral administration in mice and developed mucosal and systemic immune responses against PCV2. The titers of specific antibodies in mice administered pPG-2-Cap-LTB/L. casei 393 were higher than those in mice administered pPG-1-Cap-LTB/L. casei 393 in serum and the mucosal samples. The mucosal immune response was not only limited to the gastrointestinal tract but was also generated in other mucosal parts. Thus, the application of recombinant L. casei could aid in vaccine development for PCV2.
A Study on Role of Multispecialty Hospitals in Healthcare with Special Reference to Metro Hospital Shimoga
Authors: Manjula Bai H 
Published: July 2021

This paper is designed to study the role of multispecialty hospitals in improving the healthcare system in the economy. The study is based with special reference to METRO Hospital in Shimoga. This study is done to assess the types and components of technology used in the multispecialty hospital which has helped lots of patients in improving their healthcare and saved their lives. The study aims to understand the nature of growth and market structure in the Healthcare Sector, to know the recent trends in the present Hospital scenario, to study the opportunities and challenges in Hospital scenario, to know the marketing and business strategies of the Metro hospital and to know the implementation of technology in Metro. The study focus on the degree of management skills that the hospital utilise in effective use of technology... For the purpose of the study, the researcher has selected 50 respondents who are the patients (Both Inpatients and Outpatients) of the hospital... Descriptive research methodology is used to conduct the study. It includes survey and fact finding enquiries of different kind. It focused on the problems or the benefits availed from the hospital. All patients of various category in the Hospital were surveyed by using questionnaire and the level of satisfaction or dissatisfaction from Hospital was studied. Finally the detailed information about the benefits about the Hospital were considered... Finally, it makes an attempts to offer suggestions to the management of the hospital, regarding how better they can do to improve the management of the Hospital.
A Study on Significance of Competence of Services Provider in Knowledge- Based Service Marketing
Authors: Ponraj P , Ramprasad T P 
Published: July 2021

In India BPO is a main source of knowledge based services. BPO offers many benefits, It aids in cost reduction by lowering HR costs, such as wage bills, perks, employee benefits, and administrative overheads. Only the client is responsible for the cost of meaningful, high-quality work produced by Bookmarking knowledge-based services is a complicated process with numerous important considerations and the objective of the study is to know significance of competence of the service provider in knowledge-based services for this data has been collected from 30 sample respondents, SPSS package has been used to derive statistical inference.
“Seja homem” a narrativa, seja homem, e sua influência na subjetividade masculina
Authors: Stela Beal Thais Tatiane , Mário Cláudia Silva , Mosello Sandra Cristine Machado , Vieira Juliane Pereira , Da Silva Rosilene Monteiro 
Published: July 2021

Os discursos sobre as subjetividades relacionadas ao gênero são recorrentes na sociedade e na esfera acadêmica. Sendo impossível abarcar o todo, esta pesquisa trabalhou com um recorte de realidade. Neste momento nos debruçamos sobre o universo masculino, com o objetivo geral de compreender como a narrativa, “seja homem”, sendo uma frase tão popularizada em diferentes meios sociais, pode produzir efeitos na subjetividade masculina. Após a análise das coletas de dados sobre um olhar psicanalítico, as falas dos entrevistados fizeram emergir algumas categorias que nortearam a análise dos conteúdos, sendo elas: Inscrição Cultural, Ser Homem, Representação Fálica, Representação do Feminino, Divisão de Tarefas e Sexualidade. O estudo permitiu verificar, que mesmo em 2020, ainda encontramos indícios do machismo estrutural, hoje também reconhecido como algo prejudicial ao próprio homem, que se constituiu pela masculinidade tóxica. Ouvir sobre o peso que a narrativa “seja homem” e os seus desdobramentos, afeta a cada um, nos possibilitou a reflexão sobre essa condição do ser homem em nossa cultura. Conclui-se que mesmo sendo um assunto que vem ganhando espaço e corpo nas discussões em diferentes áreas do conhecimento, percebe-se ainda que muitas vezes surge a partir de uma reivindicação feminina, que busca equidade. Existe vontade de mudança, a busca por um novo padrão de masculinidade emerge a cada conversa e a cada discussão possibilitada na sociedade, visto que muitos homens se sentem convocados a avaliar o que escutam sobre como poderiam ser, e sentem-se impulsionados a mudanças.
Tingkat Perubahan Tutupan Lahan (Deforestasi) di DAS Tiworo Kabupaten Muna Barat
Authors: Hasddin Hasddin , Taufik Taufik , Mukaddas Jamal 
Published: July 2021

Penelitian menganalisis perubahan tutupan lahan (deforestasi) di DAS Tiworo dalam sepuluh (10) tahun yakni tutupan lahan 2010, 2015 dan 2020. Penelitian ini termasuk penelitian kualitatif dengan menggunakan desain survei. Instrument yang digunakan adalah komputer PC/laptop, software ArcGIS versi 10.4, GPS (global positioning sistem), peta DAS dan peta administrasi, kamera, alat tulis serta foto citra landsat ETM+ dan citra sentinel. Data dianalisis secara spasial (aplikasi GIS) dan deskriptif. Hasil analisis diketahui bahwa DAS Tiworo dalam periode tahun 2010-2020 mengalami deforestasi sekitar 1.107,62 ha atau sekitar 110 ha/tahun. Deforestasi yang ditandai dengan penurunan luas terjadi pada hutan sekunder dan hutan mangrove berubah menjadi kebun campuran, pertanian lahan kering dan tambak. Akibat dari penurunan luasan tersebut, maka berkonsekuensi pada peningkatan luas tutupan lahan bukan hutan/bervegetasi yakni permukiman, pertanian lahan kering, dan tambak.
Real Estate Segmentation: A Model of Real estate Decision Support System
Authors: Depari Genesis Sembiring 
Published: July 2021

Due to human limitations of computational thinking, the quality of rational decision-making is constrained, and as a result, people encounter bounded rationality. A decision support system is widely demanding in tackling this problem, especially in real estate management. This study focuses on 3 main purposes. Firstly, comparing K-means, X-means and K-medoid algorithm performance in clustering sold house characteristics to be further used for pricing houses. Second, characterizing each cluster for developing a suitable marketing strategy by utilizing machine learning technology. Lastly, providing a managerial implication as a decision support system for assisting stakeholders in making a decision. Eventually, K-means and X-means algorithm show very similar performance. X-means can automatically determine the number of clusters while k-means utilize the elbow method to find the optimum number of clusters. Three clusters were identified as cluster 0, cluster 1, and cluster 2. Cluster 0 was occupied by 85.77% of low house prices. There are two practical implications of this study. Firstly, the results of clustering analysis which reflected in a model of decision support system. Second, an intuitive and comprehensive methodological framework is presented for helping stakeholders designing a decision support system.
Cross-Cultural Adjustment and Second Language Acquisition
Authors: Ahmed Mahdi Aben 
Published: July 2021

The purpose of this study is to examine how the process of cross-cultural adjustment affects second language acquisition for Saudi students in the American universities. The sample consists of a group of Saudi students studying at one of the American universities in the USA. Interviews were carried out to collect data about daily life experiences of subjects, their feelings, and ways of coping in academic and social community, and also what motivates them to study English, and their attitudes toward the English language, its culture and its people.
The findings of this study suggest that there are several factors for healthier adjustment and greater successful acquisition of second language, and there are other factors that keep a number of the interviewees socially and psychologically distant from the target population, and the target culture. From the findings of the current study, a number of implications and recommendations for future research have been developed to help professionals involved with international students and English as a Second Language field better understand Saudis and their journey towards cross-cultural adjustment, and acquiring a second language.
[Dato’ Undang Musa Al-Haj: His Contributions to The Plural Society in Jelebu, Negeri Sembilan] Sumbangan Dato’ Undang Musa Al-Haj Kepada Masyarakat Majmuk di Jelebu, Negeri Sembilan
Authors: Haq Ibrahim Muhammad Iqbal , Rozali Ermy Azziaty 
Published: July 2021

Abstract
Jelebu is one of the district or luak located in Negeri Sembilan. Negeri Sembilan is well known with Adat Perpatih. Similarly, the Luak Jelebu also practices the unique of Adat Perpatih untill today. When we mention about Dato’ Undang, this title is part of the Adat Perpatih system itself, which specifically in the management or rulling roles. This title is the highest rank only for this four places or luak in Negeri Sembilan consists of Jelebu, Rembau, Johol and Sungai Ujong (Seremban). This title is on par with the position of Sultan or Yamtuan Besar Negeri Sembilan (The Grand Ruler of Negeri Sembilan). Hence, Dato’ Undang Musa al-Haj, the Fifteenth Dato’ Undang for Luak Jelebu, is an excellent ruler during his times. He is one of the longest ruler in Luak Jelebu for around 34 years. Throughout his leadership, he had contribute a lot of contribution to his plural society. This writing mainly focusing on Dato’ Undang Musa al-Haj in Luak Jelebu, Negeri Sembilan. This writing based on the historical summary of the position Dato’ Undang in Luak Jelebu, the appointment of the position Dato’ Undang in Luak Jelebu, the biography of Dato’ Undang Musa al-Haj and his contribution to the plural society in Luak Jelebu, Negeri Sembilan.
Keywords: Dato’ Undang Musa al-Haj, Jelebu district, Luak Jelebu, Negeri Sembilan

Abstrak
Jelebu merupakan satu daripada daerah atau luak yang terdapat di Negeri Sembilan. Negeri Sembilan terkenal dengan Adat Perpatihnya. Begitu juga dengan kawasan yang bernamakan Luak Jelebu, masyarakatnya turut mengamalkan Adat Perpatih yang unik sehingga ke hari ini. Apabila menyebut Dato’ Undang ini, gelaran tersebut berada bawah sistem Adat Perpatih itu sendiri, lebih spesifiknya dalam bahagian pentadbiran atau pemerintahan. Gelaran ini merupakan jawatan tertinggi hanya bagi empat buah kawasan atau luak di Negeri Sembilan iaitu Jelebu, Rembau, Johol dan Sungai Ujong (Seremban). Jawatan ini setaraf dengan jawatan sultan atau Yamtuan Besar Negeri Sembilan. Dalam pada itu, Dato’ Undang Musa al-Haj merupakan Dato’ Undang Ke-15 bagi Luak Jelebu, merupakan salah seorang pemerintah berwibawa ketika zaman pemerintahan beliau. Beliau merupakan antara pemerintah yang lama memerintah serta mentadbir Luak Jelebu sekitar 34 tahun. Sudah tentu, selama dalam pemerintahan tersebut, banyak sumbangan beliau terhadap masyarakat majmuk di bawah pimpinan beliau. Lantaran itu, penulisan kali ini berkisar Dato’ Undang Musa al-Haj di Luak Jelebu, Negeri Sembilan. Penulisan ini bertuntaskan sejarah ikhtisar Luak Jelebu, interpretasi jawatan Dato’ Undang di Luak Jelebu, pelantikan Dato’ Undang Luak Jelebu, biografi Dato’ Undang Musa al-Haj serta sumbangan beliau kepada masyarakat majmuk di Luak Jelebu, Negeri Sembilan.
Kata kunci: Dato’ Undang Musa al-Haj, daerah Jelebu, Luak Jelebu, Negeri Sembilan
[Muhammad Asad: The Islamic Intellectual of 20th Century] Muhammad Asad: Intelektual Islam Abad Ke-20m
Authors: Rosli Salsabila , Lubis Firuz-Akhtar 
Published: July 2021

Abstract
Muhammad Asad, a young European Jew, converted to Islam as early as 26 years old. Since then, together with Muslims he developed spectacular Islamic thoughts. He also became the bridge between two great civilizations: Islam and the West. This study details his intellectuality as an influential European Muslim of the 20th century. This study uses content and historical analysis as research techniques in obtaining information on; the Islamic traces of Muhammad Asad, his experience of Western and Islamic interaction, as well as his exceptional thinking. This study finds that there were various contributions of Muhammad Asad in Islamic intellectual world such as shariah thought, politics, literature and tafsir. Muhammad Asad's service to Islam clearly shows that he deserves to be appointed as an Islamic intellectual figure of the 20th century.

Keywords: Muhammad Asad, Western civilization, Islamic civilization, exceptional thinking

Abstrak
Muhammad Asad seorang pemuda Eropah beragama Yahudi, memeluk Islam seawal usia 26 tahun. Sejak itu, beliau bersatu bersama umat Islam dalam membangunkan pemikiran Islam yang unggul. Beliau juga menjadi penghubung dua ketamadunan besar; Islam dan Barat. Kajian ini memperincikan keintelektualan beliau sebagai seorang Islam Eropah yang berpengaruh pada abad ke-20. Teknik analisis kandungan dan kajian pensejarahan dilaksanakan untuk memperolehi maklumat mengenai; jejak Islam Muhammad Asad, pengalaman interaksi Barat dan Islam, serta pemikiran kebitaraan Muhammad Asad. Hasil kajian mendapati terdapat pelbagai sumbangan Muhammad Asad dalam dunia intelektual Islam seperti pemikiran shariah, politik, kesusasteraan dan tafsir. Jasa Muhammad Asad terhadap Islam jelas menunjukkan bahawa beliau layak diangkat sebagai tokoh intelektual Islam abad ke-20M.
Kata kunci: Muhammad Asad, tamadun Barat, tamadun Islam, pemikiran kebitaraan