bluuebunny/crossref_metadata_2025_split huggingface dataset:
Síndrome Hemofagocítico en Niños
Authors: Terán Pazmiño Edison Esteban , Paredes Castillo Fabián Patricio , Martínez Mena Jenny Maricela , Guerra Navarrete María Fernanda 
Published: March 2021

Introducción: El síndrome hemofagocítico (SHF) es reconocido como un conjunto de signos clínicos y hallazgos laboratoriales que tienen un grave compromiso en la salud y vitalidad de los niños con una incidencia de 1.2 casos/millón/año. Puede pasar subdiagnosticado y confundido con sepsis de foco inespecífico.
Caso clínico: Niño de 4 años de edad, sin antecedentes de importancia. Ingresado desde el servicio de emergencia por presentar 20 días de fiebre y dolor abdominal. Requirió intubación por franca falla respiratoria y el ingreso a la Unidad de Cuidados Intensivos Pediátricos. Con hipotensión e insuficiencia hepática, pancitopenia y esplenomegalia.
Evolución: Se descartaron infecciones bacterianas con policultivos, SARS-Cov 2 negativo, se descartaron inmunodeficiencias congénitas y adquiridas. TORCH negativo, VDRL no reactivo. La prueba de Epstein Barr fue positivo para IgM. Se determinó endocarditis con derrame pericárdico global. Estudio de biopsia medular normocromía, normocitosis, pancitopenia y blastos <5%, sin infiltración tumoral. Se estableció el Diagnóstico de SHF se inició ciclosporina y corticoterapia. Requirió ventilación mecánica por 20 días con período de pronación de 36 horas. Fue dado de alta a pediatría y posteriormente a domicilio, para control por consulta externa.
Conclusión: El diagnóstico del SHF es inusual y subestimado al momento de la evaluación clínica. En el presente reporte se asocia a la presencia del Virus Epstein Barr
Los Cambios Neurobiológicos Producidos por el Maltrato Infantil perpetúan el Ciclo de Violencia
Authors: Guerrero Aisaga María Augusta , Pineda Cruz Silvia Salomé , Salazar Pineda Natalia , Capelo Guerrero María Doménica 
Published: March 2021

Propósito del ensayo: La hipótesis del presente estudio es que los cambios Neurobiológicos producidos por el Maltrato Infantil perpetúan el Ciclo de violencia. Buscamos reportes en donde se presentan cambios Neurobiológicos y neuroendócrinos en la relación a niños con maltrato infantil.
Recientes Hallazgos: El estrés crónico en los niños produce lesiones en el sistema límbico que afecta las emociones y la memoria. Hay variantes genéticas, como por ejemplo en el gen de transporte de serotonina, estas variantes son la causa para el desarrollo de resilencia neurobiológica
Extracto: El Maltrato Infantil a temprana edad produce consecuencias devastadoras en el cerebro del niño, resultando en múltiples psicopatologías y, lo que es más importante, perpetuando o repitiendo los ciclos de violencia. Esto ocurre no únicamente por conductas aprendidas sino, sobre todo, por cambios neurobiológicos que experimentan los niños maltratados.
Spatial and Temporal Effects of Kenaf (Hibiscus cannabinus L.) Cultivation on Weed Dynamics in Southern Agro-ecologies of Nigeria
Authors: Aluko O. A. , Oyebola T. O. , Amosun J. O. , Adewunmi A. , Oluwayemi T. T. 
Published: March 2021

Weed spectrum in Kenaf fields revealed the heterogeneous flora richness of agro-ecologies and potential weed challenges. A study was conducted in the Institute of Agricultural Research and Training (IAR&T), Obafemi Awolowo University Ibadan and other substations (Ilora, Ikenne and Kishi). The effects of varied kenaf planting dates, genotypes and locations on weed dynamics and potential weed problem was investigated. Five Kenaf genotypes (Cuba 108, Ifeken DI 400, Ifeken 100, Ifeken 400 and Tianung 2) were planted. It was a 3 x 4 x 5 factorial experiment arranged in Randomized complete block design (RCBD) with three replicates. Forty five (45) weed species were identified across seventeen (17) plant families. Weed morphology comprised of broad-leaf weeds (71.11%), grass weeds (17.78%), sedge (6.67%) and spiderwort (4.44%). Abundance of broad-leaf weeds (71.11%) mostly annual, reflected regular weed control from frequent cropping patterns and agro-ecological variations. Panicum maximum, Ageratum conyzoides, Tridax procumbens, Mitracarpus villosus, Spigelia anthelmia L. and Mimosa pudica were present in the locations. Commelina erecta, C. bengalensis, Cyperus rotundus, Cyperus esculentus and Maricus alternifolius, though scanty, they were difficult-to-control weeds. Summary of weed flora richness showed that Ibadan and Ilora had thirty one (31) weed each. This represented 68.89% of the recorded weed flora composition (45) in all locations. Kishi and Ikenne had ≤ 50% of the overall weed composition recorded. This might be due to cultural practices, weed dominance and agro-ecological variance. High percentage of broad-leaf weeds (≥60%) at all locations, might resulted to keen Kenaf-weed competition due to similarity in morphology and narrows weed control option. Cultural practices, high weed fecundity, short weed life cycle (mostly annual weeds), and wide dispersal corridor in the locations maybe implicated. Weed density and weed dry weight were similar across genotypes in all locations. Ibadan had the highest weed density with the lowest weed dry weight. Ilora and Kishi had comparable weed density. Notwithstanding, highest weed dry weight was recorded in Kishi, while the lowest was recorded in Ilora. This might be due to planting dates, weed types and differences in agro-ecologies.
Occurrence of Postharvest Fungal Rots of Sweet Potato (Ipomoea batatas (L) Lam.) in Southwest Nigeria and their Control with Sawdust Extracts
Authors: Beckley F. , Awoyemi S. O. 
Published: March 2021

A study was conducted in three agroecological zones (AEZs) of Southwest, Nigeria to evaluate the incidence and pathogenicity of postharvest fungal rots of sweetpotato and their control with extracts of sawdust from some tropical trees. Survey of rotted tubers was conducted in 18 markets across the three AEZs: humid rainforest (HF), derived savannah (DS), and southern guinea savannah (SGS). Fungi associated with rotted tubers were isolated, identified and their pathogenicity determined. In vitro fungitoxicity of Anogeissus leiocarpus, Gmelina arborea and Cola nitida sawdust extracts were assessed in an experiment laid out in a Completely Randomized Design (CRD) with 3 replicates. Six fungi species found to be associated with rot on tubers were Botryodiplodia theobromae, Rhizopus stolonifer, Aspergillus niger, Trichoderma viride, Penicillium oxalicum and Fusarium oxysporum. Highest (35%) rot incidence was observed in HF zone with R. stolonifer as the most prevalent. Botryodiplodia theobromae was most prevalent (68.75%, 54.54%) in SGS and DS zones respectively. All the six isolated fungi were pathogenic to sweetpotato but induced varying levels of rot severity. Botryodiplodia theobromae, R. stolonifer or A. niger induced complete (100%) rot of inoculated tubers. Sawdust extracts reduced mycelial growth of test pathogens at three sawdust concentrations (50 g/L, 75 g/L and 100 g/L) tested. Inhibition of fungal growth increased with extract concentration. Anogeissus leiocarpus sawdust extract at 100 g/L exhibited highest range of mycelial growth inhibition (8.80 - 73.0%) across tested pathogens. Gmelina arborea sawdust extract at 100 g/L significantly inhibited (p<0.05) mycelial growth of B. theobromae, P. oxalicum and T. viride while C. nitida exhibited strong fungitoxicity to F. oxysporum at 100 g/L. Application of the sawdust extracts at 50 g/L, 75 g/L and 100 g/L concentrations has the potential to minimize postharvest fungal rot of sweetpotato.
Bacteriological Profile of Campylobacter SPP Isolated from Pigs in Cameroon: A Review
Authors: Assiene Serge Damase Oyong , Ngah Esther , Ndjonka Dieudonné 
Published: March 2021

Campylobacter is the most frequent bacteria implicated in acute gastroenteritis in the industrialized world and is considered as a major public health problem. The aim of this review is to improve our knowledge on the bacteriological profile of Campylobacter isolated from pigs. Porks, beef also represent sources of infection with these microorganisms. Campylobacter is a bacterium comprising seventeen species, including Campylobacter jejuni, Campylobacter coli and Campylobacter fetus. C. coli is the most common Campylobacter species recovered from pigs. The prevalence (46%, 52%, 75%) varies from one country to another, from the collection site. C. jejuni and C. coli grows best in a low oxygen or microaerophilic environment. The virulence markers varies among different sources of the isolates. The majority of genes were found at high levels in Campylobacter spp. isolated from pork meat (csrA, sodB, cdtB, and racR). Moreover, this review revealed virulent properties of Campylobacter isolated from swine products and high resistance rates to Tetracycline (68%), Erythromycin (61%), which may represent difficulties in campylobacteriosis treatment. Fluoroquinolones resistance (2.2%, 7%, 11%,100%) varies according to the country and the source of the sample. It will be wise to insist on hygenic measures as a solution to limit the incidence of Campylobacter and prevent dissemination of pathogens in animals (chicken, pork and beef) within slaughter-houses/ killings Cameroon.
Variant recurrence confirms the existence of a FBXO31‐related spastic‐dystonic cerebral palsy syndrome
Authors: Dzinovic Ivana , Škorvánek Matej , Pavelekova Petra , Zhao Chen , Keren Boris , Whalen Sandra , Bakhtiari Somayeh , Chih Jin Sheng , Kruer Michael C. , Jech Robert , Winkelmann Juliane , Zech Michael 
Published: March 2021

AbstractThe role of genetics in the causation of cerebral palsy has become the focus of many studies aiming to unravel the heterogeneous etiology behind this frequent neurodevelopmental disorder. A recent paper reported two unrelated children with a clinical diagnosis of cerebral palsy, who carried the same de novo c.1000G > A (p.Asp334Asn) variant in FBXO31, encoding a widely studied tumor suppressor not previously implicated in monogenic disease. We now identified a third individual with the recurrent FBXO31 de novo missense variant, featuring a spastic‐dystonic phenotype. Our data confirm a link between variant FBXO31 and an autosomal dominant neurodevelopmental disorder characterized by prominent motor dysfunction.
Flexible MXene‐Based Composites for Wearable Devices
Authors: Ma Chang , Ma Ming‐Guo , Si Chuanling , Ji Xing‐Xiang , Wan Pengbo 
Published: March 2021

AbstractIn recent decades, flexible and wearable devices have been extensively investigated due to their promising applications in portable mobile electronics and human motion monitoring. MXene, a novel growing family of 2D nanomaterials, demonstrates superiorities such as outstanding electrical conductivity, abundant terminal groups, unique layered‐structure, large surface area, and hydrophilicity, making it to be a potential candidate material for flexible and wearable devices. Numerous pioneering works are devoted to develop flexible MXene‐based composites with various functions and designed structures. Therefore, the latest progress of the flexible MXene‐based composites for wearable devices is summarized in this review, focusing on the preparation strategies, working mechanisms, performances, and applications in sensors, supercapacitors, and electromagnetic interference shielding materials. Moreover, the current challenges and future outlooks are also discussed.
Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy
Authors: Li Shu‐Lan , Jiang Peng , Jiang Feng‐Lei , Liu Yi 
Published: March 2021

AbstractTriggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H2O2) into the lethal reactive oxygen species (ROS) hydroxyl radicals (•OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor‐specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H2O2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo‐, ultrasound‐, magnetic‐, and other stimuli‐response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti‐cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial‐based chemodynamic cancer therapy. In this review, the various nanomaterials‐based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better‐quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.
Crystal phase, morphology evolution and luminescence properties of Eu3+‐doped BiPO4 phosphor prepared using the hydrothermal method
Authors: Yu Dongyan , Wu Xingya , Yan Gongqin , Cao Jieliang 
Published: March 2021

AbstractA series of Bi1‐xEuxPO4 phosphors was successfully prepared using an easy citric acid‐ assisted hydrothermal method. The effects of synthesis temperature, amount of citric acid, and Eu3+ concentration on the crystal phase, morphology, and luminescence properties were investigated. X‐ray diffraction results revealed that BiPO4:Eu3+ formed a hexagonal phase at 80°C, although it transformed to a monoclinic phase when the hydrothermal temperature was increased to 160°C. Moreover, it was found that a small amount of Eu3+ doping and the addition of citric acid introduced no secondary or related phases. The morphologies of the samples varied from nanoparticles to spherical microparticles to polyhedrons after the synthesis temperature was adjusted. Particle size was controlled by adding different amounts of citric acid. Under 394 nm excitation, the Bi0.95Eu0.05PO4 phosphor prepared at 160°C with 0.3 g of citric acid had excellent luminescence properties. A possible crystal growth mechanism during this reaction is proposed.
TGF‐β1‐induced collagen promotes chicken ovarian follicle development via an intercellular cooperative pattern
Authors: Zhou Shuo , Ma Yanfen , Yao Jinwei , Zhao An , Xie Chukang , Mi Yuling , Zhang Caiqiao 
Published: March 2021

AbstractFollicle development is a complex process under strict regulation of diverse hormones and cytokines including transforming growth factor β (TGF‐β) superfamily members. TGF‐β is pivotal for the regulation of ovarian functions under physiological and pathological conditions. In this study, effect of TGF‐β1 on chicken follicle development was examined through investigating the accumulation and action of collagen, an indispensable member of the extracellular matrix (ECM) involved in this process. The granulosa cells (GCs) and theca cells (TCs) were separated from growing follicles of the laying chicken for treatment of TGF‐β1 and analysis of expression of ECM components and key proteins in intracellular signaling pathways. Results showed that collagen was mainly distributed in the follicular theca layer and was produced with the formation of the granulosa layer during ovarian development. Collagen accumulation increased with follicle growth and treatment of GCs with TGF‐β1 elicited an increased expression of collagen. After production from GCs, collagen was transferred to the neighboring TCs to promote cell proliferation and inhibit apoptosis. Treatment of collagen remarkably increased expression of p‐ERK, mitogen‐activated protein kinase (MAPK), and p‐MAPK, but treatment with hydroxylase inhibitor (to break collagen structure) reversed these alterations. In conclusion, during follicle growth collagen was secreted by GCs under TGF‐β1 stimulation and was subsequently collaboratively transferred to neighboring TCs to increase cell proliferation and thus to promote follicle development via an intercellular cooperative pattern during development of chicken growing follicles.
CircKRT1 drives tumor progression and immune evasion in oral squamous cell carcinoma by sponging miR‐495‐3p to regulate PDL1 expression
Authors: Yang Zhongheng , Chen Weizhi , Wang Yang , Qin Mengting , Ji Yanhong 
Published: March 2021

AbstractRegulatory functions of circRNAs by targeting the micro RNA (miRNA)/mRNA axis have been increasingly found in oral squamous cell carcinoma (OSCC). CircRNA keratin 1 (CircKRT1) and miR‐495‐3p were dysregulated in OSCC. Programmed death ligand 1 (PDL1) was an important immunotherapeutic molecule in OSCC. Our objective was to explore whether circKRT1 could regulate cancer progression and immune evasion in OSCC by affecting the miR‐495‐3p/PDL1 axis. RNA expression was examined by quantitative real‐time polymerase chain reaction. All protein levels were detected by western blot. OSCC cell growth was assessed by CCK‐8 and colony formation assays. Cell migratory and invasive abilities were evaluated by transwell assay. CD8+ T‐cell cytotoxicity was determined via lactate dehydrogenase assay. CD8+ T‐cell percentage and apoptosis were analyzed by flow cytometry. Target screening was performed by Veen Diagram and RNA pull‐down assay. Target binding was verified using dual‐luciferase reporter and RNA immunoprecipitation assays. A xenograft in mice was conducted for in vivo experiment. CircKRT1 and PDL1 were highly expressed in OSCC tissues and cells. CircKRT1 knockdown repressed OSCC cell growth, migration, invasion, epithelial–mesenchymal transition, and CD8+ T‐cell apoptosis, but enhanced CD8+ T cytotoxicity and percentage. The inhibitory effects of circKRT1 downregulation on OSCC progression and immune evasion were related to PDL1 expression inhibition. CircKRT1 sponged miR‐495‐3p and miR‐495‐3p targeted PDL1. OSCC progression and immune evasion were regulated by circKRT1 via the miR‐495‐3p/PDL1 axis. CircKRT1 also facilitated OSCC progression in vivo by regulating miR‐495‐3p and PDL1. This study clarified that circKRT1 worked as a miR‐495‐3p sponge to regulate PDL1, consequently affecting cancer progression and immune evasion in OSCC.
c‐Myc‐induced circ‐NOTCH1 promotes aggressive phenotypes of nasopharyngeal carcinoma cells by regulating the miR‐34c‐5p/c‐Myc axis
Authors: Huang Wei , Song Wei , Jiang Yunfei , Chen Lejun , Lu Hong 
Published: March 2021

AbstractNasopharyngeal carcinoma (NPC) is the subclass of head and neck cancer with the highest incidence among otolaryngology malignancies. A growing amount of evidence has proven that circular RNAs (circRNAs) play key roles in the progression of multiple cancers. It has been reported that circ‐NOTCH1 is a novel circRNA and functions as an oncogene in gastric cancer, while the regulatory mechanism of circ‐NOTCH1 in NPC remains unknown. In the present research, our findings revealed that circ‐NOTCH1 was overexpressed in NPC tissues and cells. Circ‐NOTCH1 knockdown suppressed NPC cell proliferation, invasion, and migration. Subsequently, we discovered that c‐Myc can activate circ‐NOTCH1 by binding to the NOTCH1 promoter. c‐Myc functioned as a tumor promoter in NPC cells. Mechanistically, circ‐NOTCH1 served as a competitive endogenous RNA to modulate c‐Myc expression by sponging miR‐34c‐5p. Additionally, overexpression of c‐Myc reversed the circ‐NOTCH1 knockdown‐mediated inhibition of NPC cellular progression. Overall, this study suggested that c‐Myc‐induced circ‐NOTCH1 promoted malignant phenotypes of NPC cells by regulating the miR‐34c‐5p/c‐Myc axis.
VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation injury via the PINK1/Parkin pathway
Authors: Yang Xiaomei , Zhou Yuancheng , Liang Haiyan , Meng Yan , Liu Haocheng , Zhou Ying , Huang Chunhong , An Binyi , Mao Hongli , Liao Zhangping 
Published: March 2021

AbstractIschemia/reperfusion (I/R) is a well‐known injury to the myocardium, but the mechanism involved remains elusive. In addition to the well‐accepted apoptosis theory, autophagy was recently found to be involved in the process, exerting a dual role as protection in ischemia and detriment in reperfusion. Activation of autophagy is mediated by mitochondrial permeability transition pore (MPTP) opening during reperfusion. In our previous study, we showed that MPTP opening is regulated by VDAC1, a channel protein located in the outer membrane of mitochondria. Thus, upregulation of VDAC1 expression is a possible trigger to cardiomyocyte autophagy via an unclear pathway. Here, we established an anoxia/reoxygenation (A/R) model in vitro to simulate the I/R process in vivo. At the end of A/R treatment, VDAC1, Beclin 1, and LC3‐II/I were upregulated, and autophagic vacuoles were increased in cardiomyocytes, which showed a connection of VDAC1 and autophagy development. These variations also led to ROS burst, mitochondrial dysfunction, and aggravated apoptosis. Knockdown of VDAC1 by RNAi could alleviate the above‐mentioned cellular damages. Additionally, the expression of PINK1 and Parkin was enhanced after A/R injury. Furthermore, Parkin was recruited to mitochondria from the cytosol, which suggested that the PINK1/Parkin autophagic pathway was activated during A/R. Nevertheless, the PINK1/Parkin pathway was effectively inhibited when VDAC1 was knocked‐down. Taken together, the A/R‐induced cardiomyocyte injury was mediated by VDAC1 upregulation, which led to cell autophagy via the PINK1/Parkin pathway, and finally aggravated apoptosis.
A Doubly Confined Nickel‐Based Catalyst Derived from Hydrotalcite‐Montmorillonite Composite: Preparation and Hydrogenation Performance
Authors: Nie Shilin , Yan Yimeng , Li Huafan , Niu Libo , Qin Jingru , Chen Ligong , Bai Guoyi 
Published: March 2021

AbstractA doubly confined Ni‐AOM catalyst was fabricated from hydrotalcite‐montmorillonite composite by controlling the growth of hydrotalcite via a hydrothermal co‐precipitation method after the introduction of Ni2+ and Al3+ into the montmorillonite layers through an ion exchange method. The structure of this hydrotalcite‐montmorillonite composite was proved by XRD and TG/DTG. TEM results demonstrate that the nickel nanoparticles in Ni‐AOM were highly dispersed with an average particle size of 4.5 nm. Notably, Ni‐AOM showed excellent catalytic performance in the hydrogenation of dioctyl phthalate with the conversion and selectivity both being 99 %. Furthermore, it could be recycled 10 times without significant loss of activity, comparable to most noble metal catalysts. The excellent activity and stability of this catalyst was mainly attributed to the doubly confined effect of the montmorillonite laminate and Ni−Al oxide derived from hydrotalcite.