bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Endonasal Supraoptic and Infraoptic Approaches for Complex “Parasuprasellar” Lesions: Surgical Anatomy, Technique Nuances, and Case Series
Authors: Bao YouYuan , Yang YouQing , Zhou Lin , Xie ShenHao , Wu Xiao , Ding Han , Wu Jie , Xiao Li Min , Yang Le , Tang Bin , Hong Tao 
Published: June 2021

Abstract
Purpose: Surgical management of lesions involving the lateral area of the suprasellar region, including the lateral aspect of the planum sphenoidale and a tight junction region of the optic canal (OC), the anterior clinoid process (ACP), and the internal carotid artery (ICA) and its dural rings, is extremely challenging. Here, the authors introduce two novel endoscopic endonasal supraoptic (EESO) and endoscopic endonasal infraoptic (EEIO) approaches to access these regions, namely, “parasuprasellar” area.Methods: Surgical simulation of the EESO and EEIO approaches to the parasuprasellar area was conducted in 5 silicon-injected specimens. The same techniques were applied in 12 patients involving the parasuprasellar area.Results: The EESO and EEIO approaches can be used independently or in combination, but are more often employed as a complement to the endoscopic endonasal midline approach and transcavernous approach. In clinical application, the EESO and EEIO approaches were successfully performed in 12 patients harboring tumors and multiple aneurysms involving the parasuprasellar area. Gross total and subtotal tumor resection was achieved in 9 patients and 1 patient, respectively. For two patients with multiple aneurysms, the lesions were clipped selectively according to location and size. Visual acuity improved in 7 patients, remained stable in 4, and deteriorated in only 1. No postoperative intracranial infection or ICA injury occurred in this series.Conclusion: The EESO and EEIO approaches can be combined with the current endoscopic endonasal midline approach and transcavernous approach to remove extensive pathologies involving the intrasellar, suprasellar, sphenoid, and cavernous sinuses and even bifurcation of the ICA.
Effectiveness of the SARS-CoV-2 mRNA Vaccines in Pregnant Women
Authors: Butt Adeel , Abou-Samra Abdul-Badi , Chemaitelly Hiam , Khal Abdullatif Al , Coyle Peter , Saleh Huda , Kaleeckal Anvar Hassan , Latif Ali Nizar , Bertollini Roberto , Abu-Raddad Laith 
Published: June 2021

Abstract
Pregnancy may increase the risk of adverse maternal and neonatal outcomes in SARS-CoV-2 infection. Effectiveness of SARS-CoV-2 vaccines in pregnant women is not known. Using a test-negative case-control study, we determined the vaccine effectiveness of mRNA vaccines in preventing confirmed SARS-CoV-2 infection in pregnant women at a national referral hospital, which handles > 75% of the deliveries in Qatar. Among 2,020 pregnant women who met the study criteria, 397 had a positive SARS-CoV-2 RT-PCR and 1,623 had a negative test. Vaccine effectiveness ≥ 14 days after the second dose was 67.7% (95%CI 30.5–86.9), while vaccine effectiveness ≥ 14 days after the first dose but before the second dose was 40.3% (95%CI 0.0-80.4). There were nine severe/critical disease cases, and no deaths in the PCR-positive pregnant women, all among unvaccinated. The mRNA vaccines provide high level of protection against documented SARS-CoV-2 infection, which supports including pregnant women in vaccination campaigns.
Appropriateness of using vitamin K for the correction of INR elevation secondary to hepatic disease in critically ill patients: An Observational Study
Authors: Sulaiman Khalid Al , Mutairi Mashael Al , Harbi Omar Al , Duraihim Alanoud Al , Aldosary Sara , Khalil Haifa Al , Shaya Abdulrahman Al , Harbi Shmeylan Al , Alotaibi Nouf , Aamer Kholoud Al , Vishwakarma Ramesh , Asiri Mohammed Al , Katheri Abdulmalik Al , Bekairy Abdulkareem M. Al 
Published: June 2021

Abstract
Background: Hepatic diseases have been associated with an increased risk of coagulopathy and increased odds of secondary thrombosis and bleeding. Using vitamin K for correction of coagulopathy in critically ill patients is controversial with limited evidence. This study aims to evaluate the efficacy and safety of vitamin K in the correction of international normalized ratio (INR) elevation secondary to liver disease in critically ill patients.Method: A retrospective study of adult ICU patients with coagulopathy secondary to liver disease admitted to a tertiary teaching hospital in Saudi Arabia. The primary outcome was to evaluate the association between vitamin K administration and the incidence of new bleeding events in critically ill patients with INR elevation secondary to liver disease. Secondary outcomes were to evaluate the incidence of a new thrombotic event, and the degree of INR correction with vitamin K. Patients were divided into two groups based on vitamin K administration to correct INR elevation. The propensity score was generated based on disease severity scores and the use of pharmacological DVT prophylaxis. Results: A total of 98 patients were included in the study. Forty-seven patients (48%) received vitamin K during the study period. The incidence of the new bleeding event was not statistically different between groups (OR 2.4, 95% CI 0.28-21.67, P=0.42). Delta of INR reduction was observed with a median of 0.63 when the first dose is given (p-value: <.0001). However, other subsequent doses of vitamin K were not statistically significant.Conclusion: Using vitamin K for INR correction in critically ill patients with coagulopathy secondary to liver disease was not associated with a lower incidence of new bleeding events. Vitamin K was efficient in reducing INR level at the first dose, and other subsequent doses were not.
Gradual Increasing Dyslipidemia in Male Patients With Human Immunodeficiency Virus Primarily Treated With Tenofovir Plus Lamivudine Plus Efavirenz for Three Years
Authors: Liu Dafeng , Zhang Xinyi , Kang Jun , Gao Fengjiao , He Yinsheng , He Shenghua 
Published: June 2021

Abstract
Introduction: Since the development of antiretroviral therapy (ART) with TDF plus 3TC plus EFV, this specific regimen has not been studied enough with long-term lipid and uric acid monitoring.Methods: A prospective follow-up cohort study was performed. Sixty-one treatment-naive male patients with human immunodeficiency virus (HIV) were divided into three groups based on their baseline CD4+ cell count (26, 12, and 23 patients in the <200, 200 to 350, and >350 groups, respectively). The lipid and purine metabolism parameters of the patients over 144 weeks were analyzed.Result: Within 144 weeks, TG, LDL-c, TC and HDL-c gradually increased, especially the latter two (P=0.001, 0.000, respectively). Moreover, the percentages of hypercholesterolemia, hyper LDL cholesterolemia, hypertriglyceridemia and low HDL cholesterolemia also gradually increased, especially the latter (P=0.0007). The lower the baseline CD4+ cell counts were, the higher the TG levels were and the lower the TC, LDL-c and HDL-c levels were. But there was significant difference of only baseline LDL-c levels between the three groups (P=0.0457). No significant difference of the UA level and the percentages of hyperuricemia was found between the different follow-up time point groups or between the three groups (all P>0.05). The risk factors for dyslipidemia included age, anthropometric parameters and follow-up weeks, and for hyperuricemia was virus load.Conclusions: Gradual increasing dyslipidemia was found in male patients with human immunodeficiency virus primarily treated with tenofovir plus lamivudine plus efavirenz for three years. There-fore lipid metabolism parameters should be closely monitored during long-term ART with the TDF plus 3TC plus EFV regimen.
Six Year Trend Analysis of Malaria Prevalence in Bati District, Northeastern Ethiopia: A Retrospective Study
Authors: Daba Chala , Kebede Edosa , Atamo Amanuel , Reda Semere 
Published: June 2021

Abstract
Background: Malaria is still the leading cause of morbidity and mortality in developing countries including Ethiopia. Ethiopia is planned to minimize forty percent of malaria incidence at the end of 2020 by applying different prevention and control method. There is limited information about trend of malaria in the study area. Therefore, this study was designed to address this gap. Methods: Institutional based retrospective study was conducted from to determine a six-year trend analysis of malaria prevalence in the Bati district. All malaria cases were carefully reviewed by trained laboratory technologists from the laboratory record books of Bati hospital and health center. The data was entered in to excel 2013 and descriptive statistics were used to determine frequencies and percentages of malaria cases, trends of malaria transmission in terms of years and seasonal distribution. Result: A total of 84,269 and 22,185 malaria suspected patients were requested for blood films and Rapid diagnostic tests (RDT) respectively. Of this, 12,032 (11.3%) malaria cases were microscopically confirmed. Plasmodium falciparum were the most dominant parasite detected, which accounted for 57.6 %. The highest peak of malaria cases was reported during the summer season. The majority of the cases (57.2%) were reported among the >15 years age groupConclusion: Malaria is still a major public health problem in the study area. In order to decrease the number of malaria cases further, government, all healthcare workers, and community should strengthen and scale up malaria prevention and control strategies in the study area.
A closer look: High-resolution pore-scale simulations of solute transport and mixing through porous media columns
Authors: Sole-Mari Guillem , Bolster Diogo , Fernandez-Garcia Daniel 
Published: June 2021

Abstract
Mixing is pivotal to conservative and reactive transport behaviors in porous media. Methods for investigating mixing processes include mathematical models, laboratory experiments and numerical simulations. The latter have been historically limited by the extreme computational resources needed for solving flow and transport at the microscopic scale within the complex pore structure of a three-dimensional porous medium, while dealing with a sufficiently large domain in order to generate meaningful emergent continuum-scale observables. We present the results of such a set of virtual column experiments, which have been conducted by taking advantage of modern High-Performance Computing infrastructure and Computational Fluid Dynamics software capable of massively parallel simulations. The computational approach has important advantages such as full control over the experimental conditions as well as high spatial and temporal resolution of measurements. We study the roles of Péclet number and grain size variability on emergent conservative and reactive transport behaviors. Hydrodynamic dispersion results agree with the empirical and theoretical literature and link dispersivity to median grain size, while elucidating the impact of grain-size variability on the critical Péclet number. Reactive transport results also indicate that the relative degree of incomplete mixing is related to the granular material's mean hydraulic radius, and not to the median grain size. When compared to a well-known laboratory experiment with similar configuration, less incomplete mixing is observed in our simulations. We offer a partial explanation for this discrepancy, by showing how an apparent non-linear absorbance-concentration relationship may induce laboratory measurement error in the presence of local concentration fluctuations.
Changes in Neonatal Morbidity and Neonatal Care Practices of Infants Born Very Preterm in the Netherlands in the 1980s and 2000s
Authors: Sexty Reka , Pal Sylvia van der , Reijneveld Sijmen A. , Wolke Dieter , Lüchters Guido , Bakker Leonhard , Buuren Stef van , Bos Arend F. , Bartmann Peter 
Published: June 2021

Abstract
This study evaluates changes in neonatal morbidity and care practices of very preterm (VP) infants born in the Netherlands in the 1980s and 2000s and analyzes whether these changes were associated with infant and maternal characteristics, risk factors during pregnancy, and obstetrical outcomes.The community-based cohorts of POPS (1983) and LOLLIPOP (2002-03) provided perinatal data for the study. The analysis enrolled 1,228 participants born VP (before 32 weeks of gestation) and survived to 2 years of age. In 2003, mothers were on average 3.3 years older when giving birth than in 1983. Multiple birth rates increased by 50% and significantly more parents had higher education. Prevalence of severe IVH and sepsis decreased in VP infants between 1983 and 2003. LOLLIPOP infants received more often continuous positive airway pressure (CPAP), mechanical ventilation, and caffeine therapy than POPS infants. Antenatal corticosteroids and surfactant therapy were introduced only in the LOLLIPOP cohort. In 2002-03, length of stay in the NICU was reduced by 57% in LOLLIPOP (median 16 days) compared to POPS (median 38 days). LOLLIPOP infants also spent 11 days less total time in hospital after birth (median 54 days). This is a reduction of 17% compared to POPS (median 65 days). Differences persisted after adjustment for infant and maternal characteristics, risk factors during pregnancy, and obstetrical outcomes.Conclusions: Infant and mother characteristics changed considerably as well as obstetric and neonatal care practices. Outcomes of several severe neonatal morbidities improved. Length of NICU and hospital stay were significantly shorter in the 2000s.
Dysbiosis of the faecal and biliary microbiotas in biliary tract cancer
Authors: Ito Zensho , Koido Shigeo , Kato Kumiko , Odamaki Toshitaka , Horiuchi Sankichi , Akasu Takafumi , Saruta Masayuki , Hata Taigo , Kumagai Yu , Fujioka Shuichi , Misawa Takeyuki , Xiao Jin-zhong , Sato Nobuhiro , Ohkusa Toshifumi 
Published: June 2021

Abstract
Background

Characteristic bile duct and colonic microbiotas have been identified in patients with chronic biliary tract disease. Therefore, a characteristic microbiota is likely also formed in cholangio- and gallbladder carcinoma patients. This study aimed to characterize the faecal and bile microbiotas in biliary tract cancer (BTC) patients and their relationship to each other.
Methods

Patients with BTC (n = 30) and benign biliary disease (BBD) without cholangitis (n = 11) were prospectively included. Ten healthy, age-matched subjects were also recruited for faecal microbiota comparison. The colon and bile duct microbiotas were analysed by sequencing the 16S rRNA gene V3-V4 region. We also obtained live bacteria in the bile collected from three BTC patients by culture and performed metagenomics-based identification.
Results

The faecal microbiota composition differed in the BTC patients. Linear discriminant analysis (LDA) effect size (LEfSe) showed a higher Enterobacteriaceae abundance and a lower Clostridia abundance, including that of butyrate-producing bacteria including Faecalibacterium and Coprococcus, in the BTC patients than in the other subjects. Notably, 10 of 17 operational taxonomic units (OTUs) assigned to Enterobacteriaceae in the bile samples were matched with the OTUs found in the BTC subject faecal samples. Further metagenomic approaches revealed a bile-isolated strain that possessed the carcinogenic bacterial colipolyketide synthase (PKS)-encoding gene.
Conclusions

Enterobacteriaceae was enriched in the BTC faeces. Taken together with the finding that more than half of Enterobacteriaceae in the bile matched that in the faeces at the OTU level, our data suggest that faecal microbiota dysbiosis possibly contributes to BTC onset.
Design of Two-Dimensional Photonic Crystal Based Biosensors for Abnormal Tissues Analysis
Authors: Asuvaran A , Elatharasan G 
Published: June 2021

Abstract
The recognition of different classifications of brain irregular tissues is an incredible test in robot-helped Minimally Invasive Surgery (MIS) that includes connection with the tissues. In this paper, an optical sensor was designed in order to assess the Refractive Index (RI) of various brain tissues while the robotic surgery is performed. This research work is based on the 2-Dimensional (2D) Photonic Crystal (PC) bio-sensor powered by electromagnetic radiation. It reaches the range from UV to IR and is deeply intended to profoundly touch the changes in the refractive index of different tissues. Due to the fact that the refractive index of the abnormal tissues is very different from the normal tissues, the sensor can easily be distinguished the tumors, cancer-infected brain tissues, and normal brain tissues. As a result, the sensor exhibits a different range of frequency, wavelength and amplitude spectra which respond to the small changes that occur in the refractive index of the brain tissue.
Cues to Danger: Contour Features Predict Valence and Threat Judgements in Scenes
Authors: Damiano Claudia , Walther Dirk B. , Cunningham William A. 
Published: June 2021

Abstract
Quickly scanning an environment to determine relative threat is an essential part of survival. Scene gist extracted rapidly from the environment may help people detect threats. Here, we probed this link between emotional judgements and features of visual scenes. We first extracted curvature, length, and orientation statistics of all images in the International Affective Picture System image set and related them to emotional valence scores. Images containing angular contours were rated as negative, and images containing long contours as positive. We then composed new abstract line drawings with specific combinations of length, curvature, and orientation values and asked participants to rate them as positive or negative, and as safe or threatening. Low curvature, long, horizontal contour scenes were rated as positive/safe, while short, high curvature contour scenes were rated as negative/threatening. Our work shows that particular combinations of image features help people make judgements about potential threat in the environment.
Development and Validation of Prediction Model to Estimate Risk of Acute Pulmonary Embolism: Retrospective Cohort Study
Authors: Li You , Meng Yan , Fu Bowen , Xue Shuanglong , Kang Mengyang , Duan Zhenzhen , Chen Yan , Wang Yifan , Tian Hongyan 
Published: June 2021

Abstract
Background: Venous thromboembolism (VTE), clinically presenting as deep vein thrombosis (DVT) or pulmonary embolism (PE). Not all DVT patients carry the same risk of developing acute pulmonary embolism (APE).Methods: Patients who were diagnosed as symptomatic VTE between June 2013 and June 2018 (n=1582) at the First Affiliated Hospital of Xi’an Jiaotong University were enrolled in this study, of whom 783 had the DVT and APE confirmed by angiography or computed tomography pulmonary angiography (CTPA). Using the LASSO and logistics regression, we derived predictive model with 16 candidate variables to predict the risk of APE and completed internal validation.Results: Overall, 52.9% patients had DVT+APE (773 vs 1460), 47.1% patients only had DVT (687 vs 1460). The APE risk prediction model included one pre-existing disease or condition (respiratory failure), one risk factors(infection), three symptoms (dyspnea, hemoptysis, syncope), five signs (skin cold clammy, tachycardia, diminished respiration, pulmonary rales, accentuation/splitting of P2, tricuspid murmur), and six ECG indicators (SⅠQⅢTⅢ, right axis deviation, left axis deviation, S1S2S3, T wave inversion, Q/q wave), of which all were positively associated with APE. The ROC curves of the model showed AUC of 0.79 (95% CI, 0.77-0.82) and 0.80 (95% CI, 0.76-0.84) in the training set and testing set. The model showed good predictive accuracy (calibration slope, 0.83 and Brier score, 0.18).Conclusion: Based on a retrospective single-center population study, we developed a novel prediction model to identify patients with different risks for APE in DVT patients, which may be useful for quickly estimating the probability of APE before obtaining definitive test results and speeding up emergency management processes.
Manganese Limitations and the Enhanced Soil Carbon Sequestration of Temperate Rainforests
Authors: Kranabetter J Marty , Philpott Tim , Dunn Dave 
Published: June 2021

Abstract
Manganese (Mn) has been identified as a regulatory bottleneck in carbon (C) turnover because of its role as an enzymatic co-factor in the oxidative decomposition of C by Mn-peroxidase (MnP). We tested this limit on decay using forest soils from coastal British Columbia with contrasting Mn concentrations. Moderately weathered soils (Brunisols) had an average 3.6-fold increase in MnP activity within the upper soil profile in comparison to highly weathered Podzols. Ordination of the Agaricomycete fungal community, which are responsible for MnP production, confirmed significant differences in assemblages between soil types for saprotrophic fungi, particularly species within Agaricales, Trechisporales and Auriculariales. Ectomycorrhizal fungi of Pseudotsuga menziesii were equally aligned with soil type and select taxa more abundant on Brunisols may have supplemented MnP activity. A laboratory incubation with an Mn amendment produced significant interactions in MnP activity by soil type. Surprisingly, MnP activity of both Brunisol substrates declined substantially with an amendment (-56% and − 40% for forest floor and mineral soil, respectively), in contrast to Podzols (-30% and + 26%, respectively). This inhibitory response was linked to considerable uptake of the added Mn in Brunisols, and underscores how Mn2+ likely operates directly on fungi as a regulator of mnp transcription for MnP production. Our study highlights a new perspective concerning the abiotic drivers underpinning the expansive soil C stocks across perhumid temperate rainforests of the Pacific Northwest.
FURIN Correlated with Immune Infiltration Serves as a Potential Biomarker in SARS-CoV-2 Infection-Related Lung Adenocarcinoma
Authors: Luo Lianxiang , Li Manshan , Su Jiating , Yao Xinyue , Luo Hui 
Published: June 2021

Abstract
Background: FURIN, as a proprotein invertase, has been found to be expressed in a variety of cancers and plays an important role in cancer. In addition, SARS-CoV-2 requires FURIN to enter human cell. However, the role of FURIN in lung adenocarcinoma remains unclear. And the expression of SARS-CoV-2 related gene in lung adenocarcinoma have not been clarify. Methods: In this study, we obtained the expression data of Oncomine, TIMER, GEPIA, HPA. Then we used UALCAN database to analyze the expression of FURIN in different clinical feature subgroups. In PrognoScan and Kaplan-Meier plotter databases, we found a certain association between FURIN and poor OS outcomes in LUAD patients. Then we used the cBioPortal database to determine the type and frequency of FURIN changes in LUAD patients. Studies based on the TIMER database show a strong correlation between FURIN expression and various immune cell infiltrates and markers. Analysis in UALCAN database showed that the decreased promoter methylation level of FURIN in LUAD may lead to the high expression of FURIN. Furthermore, we used the LinkedOmics database to evaluate gene co-expression of FURIN in LUAD and to investigate their role in tumor immunity. Finally, we evaluated the expression of FURIN in LUAD patients who infected with SARS-CoV.Results: FURIN was highly expressed in lung adenocarcinoma. And FURIN expression was significantly associated with poor overall survival. FURIN expression was found to be correlated with six major permeable immune cells and with macrophage immune marker in LUAD patients. In addition, SARS-CoV-2 infection might affect the expression of FURIN. Conclusions: FURIN, as SARS-CoV-2 related gene, was highly expressed in LUAD. Furthermore, FURIN can be used as a promising biomarker for determining prognosis and immune infiltration in LUAD patients.