bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meeting at z ∼ 3: Young massive galaxies and an AGN within 30 kpc of the luminous QSO LBQS 0302–0019
Authors: Husemann B. , Worseck G. , Arrigoni Battaia F. , Sander A. A. C. , Shanks T. 
Published: July 2021

Context. Contrary to expectations from scenarios of black hole growth driven by galaxy interactions and mergers, dual active galactic nuclei (AGN) with kiloparsec separations are rarely observed and are very difficult to identify, in particular at high redshifts (i.e. z > 2).
Aims. Focussing on the recently discovered dual AGN system LBQS 0302−0019 at z = 3.29, we seek to identify further group members in its environment and to understand their formation history through deep high-angular-resolution imaging.
Methods. We present deep Hubble Space Telescope (HST) Wide-field Camera 3 near-infrared imaging of LBQS 0302−0019. In combination with ground-based VLT/HAWK-I imaging, we infer accurate sizes, colours, ages, and stellar masses of companion galaxies.
Results. We clearly detect four companion objects close to LBQS 0302−0019 that also have faint signatures in the ground-based images. We constrain light-weighted ages and masses for the two most prominent companions, Jil1 and Jil2, to t⋆ = 252−109+222 Myr with log(M⋆/[M⊙]) = 11.2−0.1+0.3 and t⋆ = 19−14+74 Myr with log(M⋆/[M⊙]) = 9.4−0.4+0.9, respectively. The HST data also show that the obscured AGN, previously identified by strong nebular He II emission, is associated with the young massive companion Jil2. Because very massive stars of the starburst cannot be solely responsible for the He II emission, we strengthen our initial conclusion that Jil2 has been hosting an AGN.
Conclusions. If the young starburst of Jil2 had been accompanied by sustained black hole growth, Jil2 may have contributed He II-ionising flux to create the large He II Lyα proximity zone around LBQS 0302−0019. Hence, the duration of the current luminous AGN episode of LBQS 0302−0019 may have been overestimated.
The A-shell star ϕ Leo revisited: its photospheric and circumstellar spectra
Authors: Eiroa C. , Montesinos B. , Rebollido I. , Henning Th. , Launhardt R. , Maldonado J. , Meeus G. , Mora A. , Rivière-Marichalar P. , Villaver E. 
Published: July 2021

Context. We previously suggested that variable red- and blueshifted absorption features observed in the Ca II K line towards the A-type shell star ϕ Leo are likely due to solid, comet-like bodies in the circumstellar (CS) environment.
Aims. Our aim is to expand our observational study of ϕ Leo to other characteristic spectral lines of A-type photospheres as well as to lines arising in their CS shells.
Methods. We obtained more than 500 high-resolution optical spectra collected at different telescopes over 37 nights in several observing runs from December 2015 to January 2019. Consecutive time-series spectra were taken, covering intervals of up to ~9 h on some nights. We analysed some photospheric lines, in particular Ca I 4226 Å and Mg II 4481 Å, as well as the circumstellar shell lines Ca II H and K, the Ca II IR triplet, Fe II 4924, 5018, and 5169 Å, Ti II 3685, 3759, and 3761 Å, and the Balmer lines Hα and Hβ.
Results. Our observational study reveals that ϕ Leo is a variable δ Scuti star whose spectra show remarkable dumps and bumps superimposed on the photospheric line profiles, which vary in strength and sharpness, propagate from blue- to more redshifted radial velocities, and persist for a few hours. Similarly to other δ Scuti stars, these features are likely produced by non-radial pulsations. At the same time, all shell lines present emission at ~3 km s−1 centred at the core of the CS features, and two variable absorption minima at both sides of the emission; those absorption minima occur at almost the same velocity for each line, that is, no apparent dynamical evolution is observed. The variations observed in the Ca II H and K, Fe II, and Ti II lines occur on a range of timescales from minutes to days and between observing runs, but without any clear correlation or recognisable temporal pattern among the different lines. In the case of Hα, the CS contribution is also variable in just one of the observing runs.
Conclusions. We suggest that ϕ Leo is a rapidly rotating δ Scuti star surrounded by a variable, (nearly) edge-on CS disk possibly re-supplied by the δ Scuti pulsations. The behaviour of the CS shell lines is reminiscent of that of rapidly rotating Be shell stars with an edge-on CS disk, and is clear evidence that the variations observed in the CS features of ϕ Leo are highly unlikely to be produced by exocomets. In addition, the observational results presented in this work, together with some recent results concerning the shell star HR 10, highlight the need for critical revision of the Ca II K features, which have been attributed to exocomets in other shell stars.
Smile Attractiveness Evaluation of Patients Selected for a U.S.-Based Board Certification Examination
Authors: Soh Jen , Wang Zheng Dong , Zhang Wei Bing , Kau Chung How 
Published: July 2021

Abstract
Objectives The aims of this study were to assess smile attractiveness of a collection of 68 smiling photographs of successfully treated cases submitted to the American Board of Orthodontics (ABO) clinical examination and identify variables that influence the assessment.
Materials and Methods A panel of 81 non-Caucasian assessors from various clinical disciplines were instructed to score the smile attractiveness on a visual analog scale from 1 (least attractive) to 10 (most attractive) and to select which components contributed to a lesser attractive smile. The mean, standard deviations (SDs), and quartiles of the smile attractiveness were obtained with descriptive statistics. Multilinear regression analysis was performed to investigate the scores of the perceived quality of smile attractiveness when the clinical disciplines and gender of the assessors were the factors taken into consideration. Receiver operating characteristic (ROC) curve was generated to establish the relationship between smile attractiveness and the achievement of a perfect smile.
Results The mean (SD) rating of each clinical photograph of the anterior occlusion on smiling ranged from 3.11 (1.47) as the least attractive smile to 7.59 (1.45) as the most attractive smile. The overall mean (SD) score for smile attractiveness was 5.30 (1.10). Problems associated with teeth, gingiva, and lips corresponded with a reduction of the smile attractiveness score by 1.56, 1.82, and 1.47, respectively. Gender was not associated with smile attractiveness ratings. Orthodontists, periodontists, and prosthodontists demonstrated no difference in the ratings, while plastic surgeons were more critical than orthodontists regarding smile attractiveness.
Conclusions This study suggested that only 2 out of 68 AOB validated treatment finishes had a perfect and attractive smile.
Novel Indigenous Probiotic Lactobacillus reuteri Strain Produces Anti-biofilm Reuterin against Pathogenic Periodontal Bacteria
Authors: Widyarman Armelia Sari , Theodorea Citra Fragrantia 
Published: July 2021

Abstract
Objective The aim of this study was to evaluate the effect of reuterin produced by a novel probiotic strain of Lactobacillus reuteri against periodontal biofilms.
Materials and Methods L. reuteri LC382415 (an indigenous Indonesian strain) was cultured in Man, Rogosa, and Sharpe (MRS) agar in anaerobic conditions for 24 hours. To isolate reuterin, L. reuteri was suspended in 300-mM glycerol in MRS broth and incubated under anaerobic conditions for 3 hours, and the supernatant fraction was filtered. The presence of reuterin was confirmed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), and its concentration was determined. The effect of reuterin on Porphyromonas gingivalis ATCC 33277 and T. denticola ATCC 35405 biofilms was evaluated using biofilm assays. Biofilms were formed by incubating bacteria in 96-well microplates for 48 hours. A dose-dependent experiment was performed with reuterin concentrations of 12.5, 25, 50, and 100 μg/mL on biofilms. The inhibitory effect was measured at 1, 3, 6, and 24 hours. The biofilm masses were measured at 490 nm. Statistical analysis was using one-way ANOVA.
Results The SDS-PAGE assay confirmed the presence of reuterin (52 kDa) in the culture supernatant of the L. reuteri strain. Reuterin in a concentration as low as 12.5 μg/mL significantly inhibited single- and mixed-species biofilms (p < 0.05).
Conclusions This is the first study to demonstrate the promising effect of reuterin isolated from L. reuteri LC382415 against periodontal bacteria. Further studies are warranted to explore the mechanism of this active component.
Fairness, technology and the ethics of Paralympic sport classification
Authors: McNamee Mike , Parnell Richard , Vanlandewijck Yves 
Published: July 2021

ABSTRACTFairness in sport is a widely shared meritocratic norm. Its application is usually restricted to equality of opportunity to compete for victory. Paralympic sports lay down a further challenge in that equality of opportunity must be shaped by considerations of fairness, evidenced by the development of discrete competition categories to construct fair and meaningful contests. In this article, we extend these philosophical ideas to consider how Fair Equality of Opportunity might operate in the context of Paralympic sports classification. We articulate three conceptions of fairness relevant to these sports: (i) background fairness; (ii) procedural fairness; and (iii) stakes fairness. We critically review the International Paralympic Committee's Policy on Sport Equipment in relation to the first two conceptions and argue that greater clarification, theorization and rule modification is required if physical prowess, as opposed to equipment technology, is to be assured as the dominant determinant of Paralympic athletic success.
Mimicry: just wing it. Wing shape comparison between a mimicking swallowtail and its toxic model
Authors: Nixon Kyra J A , Parzer Harald F 
Published: July 2021

AbstractFemale eastern tiger swallowtails (Papilio glaucus) are well-known wing coloration mimics of the toxic pipevine swallowtail (Battus philenor). Given that forewing shape is an important component of butterfly flight behaviour found in unpalatable species, we hypothesized that the mimicking females also mimic the forewing shape of their poisonous model. Thus, we predicted that mimicking eastern tiger swallowtails have a more similar wing shape to their model compared with their non-mimicking conspecific morphs. In order to test this, we compared the forewing of the model with mimicking and non-mimicking eastern tiger swallowtail morphs using a standard geometric morphometrics approach. Contrary to our hypothesis, we found significant differences of forewing shape between the two species, with no overlap, regardless of the morph. However, mimicking and non-mimicking female eastern tiger swallowtails were significantly different from each other in wing shape. This indicates that either pleiotropic effects, possibly owing to wing coloration mimicry, or selection for different flight patterns in mimics informed the evolution of forewings in this species. Additionally, we found sexual dimorphism in forewing shape within each species, which supports research indicating that both sexual selection and sex-specific natural selection are important drivers in wing shape evolution.
Responding to Ecological Transformation: Mental Models, External Constraints, and Manager Decision-Making
Authors: Clifford Katherine R , Cravens Amanda E , Knapp Corrine N 
Published: July 2021

AbstractEcological transformation creates many challenges for public natural resource management and requires managers to grapple with new relationships to change and new ways to manage it. In the context of unfamiliar trajectories of ecological change, a manager can resist, accept, or direct change, choices that make up the resist-accept-direct (RAD) framework. In this article, we provide a conceptual framework for how to think about this new decision space that managers must navigate. We identify internal factors (mental models) and external factors (social feasibility, institutional context, and scientific uncertainty) that shape management decisions. We then apply this conceptual framework to the RAD strategies (resist, accept, direct) to illuminate how internal and external factors shape those decisions. Finally, we conclude with a discussion of how this conceptual framework shapes our understanding of management decisions, especially how these decisions are not just ecological but also social, and the implications for research and management.
Distinct Causal Influences of Dorsolateral Prefrontal Cortex and Posterior Parietal Cortex in Multiple-Option Decision Making
Authors: Woo Tsz-Fung , Law Chun-Kit , Ting Kin-Hung , Chan Chetwyn C H , Kolling Nils , Watanabe Kei , Chau Bolton K H 
Published: July 2021

Abstract
Our knowledge about neural mechanisms underlying decision making is largely based on experiments that involved few options. However, it is more common in daily life to choose between many options, in which processing choice information selectively is particularly important. The current study examined whether the dorsolateral prefrontal cortex (dlPFC) and posterior parietal cortex (PPC) are of particular importance to multiple-option decision making. Sixty-eight participants received anodal high definition-transcranial direct current stimulation (HD-tDCS) to focally enhance dlPFC or PPC in a double-blind sham-controlled design. Participants then performed a multiple-option decision making task. We found longer fixations on poorer options were related to less optimal decisions. Interestingly, this negative impact was attenuated after applying anodal HD-tDCS over dlPFC, especially in choices with many options. This suggests that dlPFC has a causal role in filtering choice-irrelevant information. In contrast, these effects were absent after participants received anodal HD-tDCS over PPC. Instead, the choices made by these participants were more biased towards the best options presented on the side contralateral to the stimulation. This suggests PPC has a causal role in value-based spatial selection. To conclude, the dlPFC has a role in filtering undesirable options, whereas the PPC emphasizes the desirable contralateral options.
Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder
Authors: Shiohama Tadashi , Ortug Alpen , Warren Jose Luis Alatorre , Valli Briana , Levman Jacob , Faja Susan K , Tsujimura Keita , Maunakea Alika K , Takahashi Emi 
Published: July 2021

Abstract
Early interventions for autism spectrum disorder (ASD) are increasingly available, while only 42–50% of ASD children are diagnosed before 3 years old (YO). To identify neuroimaging biomarkers for early ASD diagnosis, we evaluated surface- and voxel-based brain morphometry in participants under 3YO who were later diagnosed with ASD. Magnetic resonance imaging data were retrospectively obtained from patients later diagnosed with ASD at Boston Children’s Hospital. The ASD participants with comorbidities such as congenital disorder, epilepsy, and global developmental delay/intellectual disability were excluded from statistical analyses. Eighty-five structural brain magnetic resonance imaging images were collected from 81 participants under 3YO and compared with 45 images from 45 gender- and age-matched nonautistic controls (non-ASD). Using an Infant FreeSurfer pipeline, 236 regionally distributed measurements were extracted from each scan. By t-tests and linear mixed models, the smaller nucleus accumbens and larger bilateral lateral, third, and fourth ventricles were identified in the ASD group. Vertex-wise t-statistical maps showed decreased thickness in the caudal anterior cingulate cortex and increased thickness in the right medial orbitofrontal cortex in ASD. The smaller bilateral accumbens nuclei and larger cerebral ventricles were independent of age, gender, or gestational age at birth, suggesting that there are MRI-based biomarkers in prospective ASD patients before they receive the diagnosis and that the volume of the nucleus accumbens and cerebral ventricles can be key MRI-based early biomarkers to predict the emergence of ASD.
The size of apolipoprotein (a) is an independent determinant of the reduction in lipoprotein (a) induced by PCSK9 inhibitors
Authors: Blanchard Valentin , Chemello Kévin , Hollstein Tim , Hong-Fong Clément Chong , Schumann Friederike , Grenkowitz Thomas , Nativel Brice , Coassin Stefan , Croyal Mikaël , Kassner Ursula , Lamina Claudia , Steinhagen-Thiessen Elisabeth , Lambert Gilles 
Published: July 2021

Abstract

Aims
Lipoprotein (a) [Lp(a)] is a lipoprotein species causatively associated with atherosclerosis. Unlike statins, PCSK9 inhibitors (PCSK9i) reduce Lp(a), but this reduction is highly variable. Levels of Lp(a) are chiefly governed by the size of its signature protein, apolipoprotein (a) [apo(a)]. Whether this parameter determines some of the reduction in Lp(a) induced by PCSK9i remains unknown. We aimed to investigate if the Lp(a) lowering efficacy of PCSK9i is modulated by the size of apo(a), which is genetically determined by the variable number of KIV domains present on that protein.

Methods and results
The levels of Lp(a) and the size of apo(a) were assessed in plasma samples from 268 patients before and after treatment with PCSK9i. Patients were recruited at the Outpatient Lipid Clinic of the Charité Hospital (Berlin) between 2015 and 2020. They were hypercholesterolaemic at very high cardiovascular disease risk with low-density lipoprotein (LDL)-cholesterol levels above therapeutic targets despite maximally tolerated lipid-lowering therapy. Patients received either Alirocumab (75 or 150 mg) or Evolocumab (140 mg) every 2 weeks. Apo(a), apoB100, and apoE concentrations as well as apoE major isoforms were determined by liquid chromatography high-resolution mass spectrometry. Apo(a) isoforms sizes were determined by western blot. PCSK9i sharply reduced LDL-cholesterol (−57%), apoB100 (−47%), and Lp(a) (−36%). There was a positive correlation between the size of apo(a) and the relative reduction in Lp(a) induced by PCSK9i (r = 0.363, P = 0.0001). The strength of this association remained unaltered after adjustment for baseline Lp(a) levels and all other potential confounding factors. In patients with two detectable apo(a) isoforms, there was also a positive correlation between the size of apo(a) and the reduction in Lp(a), separately for the smaller (r = 0.350, P = 0.0001) and larger (r = 0.324, P = 0.0003) isoforms. The relative contribution of the larger isoform to the total concentration of apo(a) was reduced from 29% to 15% (P &lt; 0.0001).

Conclusions
The size of apo(a) is an independent determinant of the response to PCSK9i. Each additional kringle domain is associated with a 3% additional reduction in Lp(a). This explains in part the variable efficacy of PCSK9i and allows to identify patients who will benefit most from these therapies in terms of Lp(a) lowering.
The curious case of a massive right heart thrombosis: a case report
Authors: Artico Jessica , Belgrano Manuel , Bussani Rossana , Sinagra Gianfranco 
Published: July 2021

Abstract

Background
Intraventricular masses are a relatively rare condition ranging from asymptomatic to potentially life-threatening situations.

Case summary
Herein, we report a case of a 49-year-old woman under investigation for a massive right ventricular (RV) mass who underwent complete investigation for possible differential diagnosis, in the suspect of RV tumour. Multimodality imaging with cardiac computed tomography and magnetic resonance imaging showed the presence of a massive thrombus partially obliterating the right ventricle. Surgical removal of the mass showed a large area of stratified thrombosis with an underlying area of endocardial fibrosis. The patient has been then discharged in good clinical condition and with lifetime oral anticoagulation.

Discussion
Massive RV thrombosis is a rare yet potentially fatal condition. Invasive management is preferable and lifetime anticoagulation is required to reduce possible downstream thrombotic complications.
Recurrent embolisms despite adequate anticoagulant therapy in a patient with prosthetic heart valves and atrial fibrillation: a case report
Authors: Marschall Alexander , Rodriguez Torres Diego , Rueda Liñares Andrea , Martí Sánchez David 
Published: July 2021

Abstract

Background
Antithrombotic management in patients with atrial fibrillation (AF) that have undergone heart valve surgery may be challenging, especially in the context of thromboembolic events during follow-up. The combination of pharmacological therapies with modern transcatheter interventions allows these more complex cases to be overcome.

Case summary
We present the case of a 66-year-old female with a history of AF and mechanical aortic and mitral valve replacement, which was admitted to the hospital complaining of dizziness and unsteady gait. A computerized tomography scan of the brain confirmed the diagnosis of embolic stroke. Two years later, the patient complained of sudden onset of chest pain, accompanied by electrocardiographic abnormalities and elevated high-sensitivity troponin T. Emergency cardiac catheterization revealed embolic myocardial infarction with distal occlusion of the obtuse marginal artery. Again, 2 years later, the patient suffered a new cerebral embolic event. Given the adequate anticoagulation therapy throughout almost the entire clinical course, percutaneous left atrial appendage closure was proposed as an adjunct to vitamin K antagonist treatment. Notably, intraprocedural transoesophageal echocardiography revealed the presence of a previously undetected left atrial appendage thrombus, thus an embolic protection device was used during the procedure, which was successfully carried out without complications.

Discussion
This case report demonstrates the complexity of the antithrombotic management in patients with AF and prosthetic heart valves, and highlights the importance of an individualized approach, integrating new therapeutic strategies to achieve success, in patients that present thromboembolic events despite adequate anticoagulation therapy.
Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches
Authors: Kerever Aurelien , Nagahara Fumina , Keino-Masu Kazuko , Masu Masayuki , van Kuppevelt Toin H , Vivès Romain R , Arikawa-Hirasawa Eri 
Published: July 2021

Abstract
Fractones, specialized extracellular matrix structures found in the subventricular zone (SVZ) neurogenic niche, can capture growth factors, such as basic fibroblast growth factor, from the extracellular milieu through a heparin-binding mechanism for neural stem cell (NSC) presentation, which promotes neurogenesis. During aging, a decline in neurogenesis correlates with a change in the composition of heparan sulfate (HS) within fractones. In this study, we used antibodies that recognize specific short oligosaccharides with varying sulfation to evaluate the HS composition in fractones in young and aged brains. To further understand the conditions that regulate 6-O sulfation levels and its impact on neurogenesis, we used endosulfatase Sulf1 and Sulf2 double knockout (DKO) mice. Fractones in the SVZ of Sulf1/2 DKO mice showed immunoreactivity for the HS epitope, suggesting higher 6-O sulfation. While neurogenesis declined in the aged SVZ of both wild-type and Sulf1/2 DKO mice, we observed a larger number of neuroblasts in the young and aged SVZ of Sulf1/2 DKO mice. Together, these results show that the removal of 6-O-sulfation in fractones HS by endosulfatases inhibits neurogenesis in the SVZ. Our findings advance the current understanding regarding the extracellular environment that is best suited for NSCs to thrive, which is critical for the design of future stem cell therapies.