bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Casebook of Sir Edward Coke
Authors: Ward Ian 
Published: September 2021

Abstract
Sir Edward Coke, Jacobean Lord Chief Justice, is commonly regarded as being one of the great jurists in English legal history. In considerable part, for reason of his vigorous defence of the courts of common law against the seeming intrusions of royal prerogative, his running dispute with King James I is renowned, not least as a precursor to the civil wars which would later engulf James’s son, King Charles I. The purpose of this essay is revisit Coke and, more closely still, some of his most famous judgments, in order to trace the origins of the principle of ‘legality’. It will close in whimsical tones, by wondering what Coke might have thought of ‘legal’ regime put in place in the UK during the coronavirus pandemic.
The Evaluation of home medication review for patients with type 2 diabetes mellitus by community pharmacists: a randomised controlled trial
Authors: Rosli M. Rozaini , Neoh Chin F. , Wu David B. , Hassan Nazariah W. , Mahmud Mahani , Rahimi Afifah , Karuppannan Mahmathi 
Published: September 2021

Background: Successful diabetes treatment requires commitment and understanding of disease management by the patients.
Objective: This trial aimed to evaluate the programme effectiveness of home medication review by community pharmacists (HMR-CP) in optimising diabetes care and reducing medication wastage.
Methods: A randomised controlled trial was conducted on 166 patients with Type 2 Diabetes Mellitus (T2DM) who were randomly assigned to the intervention or control groups. The intervention group received HMR-CP at 0-month, 3-month, and 6-month. The primary outcome was haemoglobin A1c (HbA1c) while clinical outcomes, anthropometric data, and humanistic outcomes were the secondary outcomes. For the intervention group, drug-related problems (DRP) were classified according to the Pharmaceutical Care Network Europe Foundation (PCNE). Medication adherence was determined based on the Pill Counting Adherence Ratio (PCAR). The cost of medication wastage was calculated based on the total missed dose by the T2DM patients multiplied by the cost of medication. General linear model and generalised estimating equations were used to compare data across the different time-points within and between the groups, respectively.
Results: No significant difference was observed in the demographic and anthropometric data at baseline between the two groups except for fasting blood glucose (FBG). There was a significant reduction in the HbA1c (-0.91%) and FBG (-1.62mmol/L) over the study period (p<0.05). A similar observation was noted in diastolic blood pressure (DBP) and total cholesterol (TC) but not in high-density lipoprotein (HDL), and anthropometric parameters. Both utility value and Michigan Diabetes Knowledge Test (MDKT) scores increased significantly over time. As for the intervention group, significant changes in PCAR (p<0.001) and the number of DRP (p<0.001) were noted.
Conclusions: HMR-CP significantly improved the glycaemic control, QoL, medication adherence, and knowledge of T2DM patients as well as reduced the number of DRP and cost of medication wastage. However, the impact of HMR-CP on certain clinical and anthropometric parameters remains inconclusive and further investigation is warranted.
Uma Década de Estudos sobre Economia Circular: Tendências e Reflexões Através de Análise Bibliométrica Internacional
Authors: Farias Fabíola Gomes , Pinto Francisco Roberto , Araújo Dhieciane de Sousa , Menezes Bárbara Sampaio de , Andrade Roberta Dutra de 
Published: September 2021

Objetivo: Registrar a produção científica internacional das dimensões da Economia Circular nos últimos dez anos. Método: Usou-se a análise bibliométrica em duas etapas, utilizando-se abordagens qualitativa e quantitativa. Aplicou-se qualitativamente a técnica de meta-análise em trajeto duplo, macroanálise e microanálise, modelo metodológico baseado em Pereira et al. (2018). Utilizou-se quantitativamente a análise de hot-topics, a fim de estimar as produções dentro da área de estudo, mensurando pesquisas para orientar futuros pesquisadores acerca dos temas que estão sendo trabalhados dentro da Economia Circular. Principais resultados – Foram mapeadas 131 produções, com aumento de volume considerável em 2018. Com o VOSviewer, apontam-se, dentre outros, o trabalho de Ghisellini, Cialani e Ulgiati (2016) como o de maior ênfase e citação. O Journal of Cleaner Production possui maior expressão em quantidade de publicações periódicas. Pelo cálculo do h-b index e m index, entre os 15 hot-topics relacionados à Economia Circular, têm-se os mais importantes: Ecologia Industrial, Sustentabilidade, Simbiose Industrial e Inovação. Relevância/originalidade - Como originalidade, a análise de hot-topics ajuda no vislumbre de emersão e possíveis tendências globais no assunto, já que se observa uma área de pesquisa ainda em formação e com bastante potencial de desenvolvimento. Contribuições teóricas/metodológicas: Espera-se auxiliar os pesquisadores da área para que possam recorrer aos periódicos mais assertivos e trabalhos mais relevantes (rede de co-citações), sabendo quais termos são mais fortes e como estes correlacionam-se entre si (rede de co-ocorrências).
Molecular Markers for Metabolic Adaptation in Dairy Cows: SNAI2 Gene Variations
Authors: Bhat S.V. Vasudhar , Shynu M. , Divya P.D. , Desai Akshatha G. , Akhil G.H. 
Published: September 2021

Background: Healthy transition from non-lactating pregnant state to non-pregnant lactating state is an important in the profitability of dairying. Though feeding and managemental practices play an important role in the adaptation to transition, animals kept on similar feeding and management exhibit differences in adaptation indicating an underlying genetic cause. In the present study, the sequence of gene SNAI2, which is considered to have an effect on metabolic adaptability has been compared among animals with apparently varying adaptability, as indicated by their β-hydroxy butyric acid (BHBA) concentration. Methods: During the period from August 2018 to May 2019, blood was collected and serum was separated from 30 pregnant cross bred (belonging to Sunandini genetic group of cross bred cattle of Kerala) dairy cows at fortnightly intervals from four weeks before the predicted day of parturition until four weeks after parturition. Concentration of BHBA was determined. Based on BHBA concentration the animals were sorted into two groups (High BHBA and low BHBA) using cluster analysis. Blood was collected, DNA extracted and SNAI2 gene amplified using custom synthesised primers. Amplicons from representative animals of each group were sequenced. The sequences obtained were aligned and compared using clustal-ω. Result: The comparison of the sequence of SNAI2 gene amongst the animals having high BHBA and those with low BHBA revealed two variations between the groups, one at promoter region, 61 bp upstream to the gene and other was at exonic region at 1560 bp. In silico structural analysis revealed difference in protein structure. The changes observed in the gene SNAI2 between the sets of animals grouped based on BHBA has to be studied on a larger population to ascertain the suitability of them being used as markers of genetic selection for metabolic adaptability, which in turn can increase the profitability of dairying.
Comparison of minimally invasive plate osteosynthesis and intramedullary nailing in the treatment of distal extraarticular tibial fractures
Authors: KUMBARACI Mert , SAVRAN Ahmet 
Published: September 2021

Aim: Our study’s aim was to investigate the effectiveness of minimal invasive plate osteosynthesis (MIPO) and intramedullary nailing (IMN) in extraarticular distal tibia fractures and to compare the outcomes of these two treatment methods.
Materials and Methods: Between January 2008 and January 2015, 59 patients had extraarticular distal tibia fracture and treated with MIPO or IMN were evaluated retrospectively. Postoperative x-rays were evaluated for fracture consolidation and angular deformities. For the functional evaluations of the patients Olerud-Molender Ankle Scoring (OMAS) method was used and ankle joint range of motion was measured by goniometer.
Results: At the last visit, all the fractures consolidated. Average union time was 16.1weeks (range, 12-24 weeks) in MIPO group and 15.5 weeks (range 10-24 weeks) in IMN group, respectively (p = 0.254). The mean OMAS scores were 67.5 (range 40–90) and 63 (range 30-90) in the IMN and MIPO groups, respectively (p= 0.12). The mean operation time was 95(range 45-115) minutes in IMN group and 75(range 40-100) minutes in MIPO group (p= 0.04). The mean operative radiation exposure times were 30(range 8-143) and 17 (range 5-65) seconds in IMN and MIPO groups, respectively (p= 0.03). Angular deformities were found in IMN group at 7 (23%) patients and in MIPO group at 5 (17%) patients, respectively. Soft tissue problems were seen in more patients in MIPO group.
Conclusion: In conclusion, IMN and MIPO can be used safely in the treatment of distal tibial metaphyseal fractures. While IMN caused more angular deformity and more union delay, patients treated with MIPO had poorer functional results and more soft tissue problems.
LIMITES DAS RESTRIÇÕES AOS DIREITOS FUNDAMENTAIS EM TEMPOS DE CRISE, ORÇAMENTO PÚBLICO E O PERIGO DA JURISDIÇÃO CONSTITUCIONAL DE EXCEÇÃO
Authors: Oliveira Jadson Correia de , Fernandez Filho Luiz Augusto Agle 
Published: September 2021

O presente artigo tem por finalidade identificar a existência de um núcleo essencial de Direitos Fundamentais que mesmo em tempos de crise devem ser respeitados e promovidos, bem como os limites da atuação do Poder Judiciário nessa missão. Para tanto, inicialmente serão analisados as balizas constitucionais do estado de exceção, tomando-se como exemplo a atual pandêmia decorrente do novo coronavírus (Sars-CoV-2), que como se verá, não pode servir como uma cortina de fumaça para a flexibilização irrestrita das normas da Constituição, nem como escusa para o retrocesso e violação dos direitos e garantias fundamentais. Em seguida, será abordado os principais princípios constitucionais que fundamentam o direito a prestação mínima do Estado e as liberdades individuais dos cidadãos, sopesando-se as dificuldades orçamentárias para a promoção desses Direitos, no cenário de crise econômica, decorrente do combate a calamidade pública. Ao final, serão analisados os princípios dos direitos fundamentais, e a cláusula pétrea da separação dos Poderes, em face da ordem democrática e as limitações da jurisdição constitucional no enfretamento das crises institucionais. A análise será por meio de pesquisa bibliográfica e normativa, e o princípio da proporcionalidade se demonstrará como um importante instrumento, a nível de compatibilizar os direitos (fundamentais) individuais e coletivos, com a ordem constitucional democrática.
Fixed Point Theorem on Contractive Mapping in Standard 2-Normed Spaces
Authors: Ammari Salsabila , Nur Muh , Aris Naimah 
Published: September 2021

This paper discussed about the proof of the fixed point theorem on the standard 2-normed spaces by using completeness. The completeness of the standard 2-normed spaces is shown by defining a new norm. Two linear independent vectors on standard 2-normed spaces are used to define the new norm, namely which has been shown to be equivalent to standard norm.
Traumatic Anterior L4 Fracture Dislocation With Iliac Artery Compression in a 6-Year-Old Patient
Authors: Barry Kenton , Hoopes Robert , Soldes Oliver , Martinek Melissa , Albert Michael 
Published: September 2021

Case:
A six-year-old Caucasian boy sustained an L4 anterior fracture dislocation with cauda equina transection at L3/L4 level with L4 vertebral body compression of the left common iliac artery after a single motor vehicle accident. He was treated with emergent open reduction and pedicle screw fixation with return of left common iliac patency. This was followed by multiple bowel resections on postadmission day 3.

Conclusion:
Anterior spinal fracture dislocations in pediatric patients are rare, caused by high-energy collisions, and are often complicated by multiple traumatic injuries, including vascular and neurological compromise that necessitate emergent intervention.
Risk Factors for Premature Rupture of the Membranes
Authors: Turlina Lilin , Ummah Faizatul , Sulistyowati  
Published: September 2021

The incidence of premature rupture of membranes (PRM) ranges from 8-10% at term pregnancy and 1% in preterm pregnancy. The incidence of PRM at RSUD dr. SoegiriLamongan in 2017 amounted to 16,43%. The purpose of this study was to analyze risk factors of the occurrence of premature rupture membranes in RSUD Dr. SoegiriLamongan. The research used descriptive analytical method with cross sectional approach. The sample is 268 maternity mothers, divided into 134 mothers giving birth with PRM and 134 normal maternity mothers at Dr. Soegiri Lamongan on 2018. Sampling is done by simple random sampling. Data collection uses patient medical record and with multivariate multiple logistic regression analysis.The results showed that presentation abnormalities with a p value of 0.045 <0.05 and CPD with a p value of 0.002 <0.05. Based on the Odds Ratio (OR) values ​​as follows: Maternal age OR 1,141, OR parity 0.933, OR fetal presentation 2,779, OR Twins 1,394, OR CPD 6. and OR Large infants 0.783.Meaning that there was a significant influence between fetal presentation and CPD on PRM.
Fine Structure Constant derived from Principle Theory.
Authors: Geilhaupt Manfred 
Published: September 2021

Abstract
Derivation of mass (m), charge (e) and fine structure constant (FSC) from theory are unsolved problems in physics up to now. Neither the Standard Model (SM) nor the General theory of Relativity (GR) has provided a complete explanation for mass, charge and FSC. The question “of what is rest mass” is therefore still essentially unanswered. We will show that the combination of two Principle Theories, General Relativity and Thermodynamics (TD), is able to derive the restmass of an electron (m) which surprisingly depends on the (Sommerfeld) FSC (same for the charge (e)).
Effectiveness of Modified Buzhong Yiqi Decoction In Treating Myasthenia Gravis: Study Protocol For A Series Of N-of-1 Trials
Authors: Weng Senhui , Li Jinghao , Chen Benshu , He Long , Zhong Zhuotai , Huang Linwen , Liu Fengbin , Jiang Qilong 
Published: September 2021

Abstract
Background: Myasthenia gravis (MG) is an acquired autoimmune disease with high heterogeneity. The disease is chronic, relapsing repeatedly and progressive with acute exacerbation occasionally. Although the treatment of MG has developed, it is still unsatisfactory and has some unexpected side effects. Traditional Chinese medicine(TCM) has shown great potential in MG treatment, including relief of muscle weakness syndrome, improvement of patient’s quality of life and reduction of side effects of western medicine. The purpose of this study is to evaluate the effectiveness of Modified Buzhong Yiqi Decoction (MBYD) as an add-on therapy for MG through a small series of N-of-1 trials.Methods: Single-centre, randomized, double-blind, 3 crossover N-of-1 trials will be conducted to enroll 12 adult patients with MG diagnosed as spleen-stomach deficiency syndrome or spleen-kidney deficiency syndrome in TCM. Each N-of-1 trial has 3 cycles of two 4-week periods containing the MBYD period and placebo period. The wash-out interval of 1-week is prior to switching each period. Primary outcome: Quantitative Myasthenia Gravis (QMG). Secondary outcomes: the following scales: myasthenia gravis composite (MGC), myasthenia gravis activities of daily living profile (MG-ADL), myasthenia gravis quality of life (MG-QOL); the level of CD4+FoxP3+Treg cells and cytokines (IL-4, IL-17A, INF-γ, TGF-β) in the peripheral blood; the alterations of the composition of gut microbiota; reduction of the side effects of western medicine. Discussion: Paired t tests or Wilcoxon signed rank tests will be used to analyse this trials’ data and the results we arrived at will be interpreted cautiously. We assumed that this study would reveal that MBYD is effective for MG and provide robust evidence of the efficacy of TCM to treat MG. Trial registration: Chinese Clinical Trial Register, ID: ChiCTR2000040477, registration on 29 November 2020, http://www.chictr.org.cn/showprojen.aspx?proj=64688.
Sun-Pointing Attitude Control Scheme for Magnetic-based Satellite
Authors: Xia Xiwang , ZHANG Yonghe , Jiang Jun 
Published: September 2021

Abstract
For some low-orbit satellites, SADA (solar array drive assembly) is not necessary but steady sun-pointing is required. Magnetic-based attitude control schemes are adopted by more and more low-cost low-orbit satellites and magnetic-based sunpointing attitude control schemes have been proposed for various satellites. For magnetic Attitude Determination and Control System (ADCS), magnetometer and magnetic torquer are the core ADCS components while sun sensor and gyro, which would be employed to determine or estimate sun vector, are important ones. Due to the underactuated characteristics, magnetic attitude control torque could not stabilize the full attitude but the two components of the attitude, simultaneously, which means that magnetic attitude control effort could orientate the solar panels to the Sun. A Lyapunov function, combining the rotational energy and sun angle, is formulated and a PD-type sun-pointing attitude control scheme is proposed to meet the requirements corresponding to sun-pointing task. Further, the effectiveness of the PD-type sun angle-based magnetic attitude control scheme, composed of proportional term, damping term and spinning term, has been verified by use of Lyapunov direct method. Simulations show that, the proposed PD-type attitude control scheme is a suitable sun-pointing scheme for magnetic satellites.
The 12-year Experience - A Retrospective and Hospital-based Study of Gestational Trophoblastic Neoplasia in the Northwest of China
Authors: Hao Jiatao , Ma Minghai , Li Peipei , Wang Luyuan , Yu Hui , Xue Yan , An Ruifang , Zhu Kexiu 
Published: September 2021

Abstract
Purpose: To analyze clinical features of gestational trophoblastic neoplasia (GTN) patients who received initial treatments at the First Affiliated Hospital of Xi'an Jiaotong University.Methods: The patient record system was screened to extract clinical data including demographics, pregnancy history, diagnosis, staging, prognostic score, treatment. Student t test, x2 test, and Fischer’s exact test were used.Results: This study included 387 patients with GTN. Patients were divided into 2009-2014 and 2015-2020 groups, including 177 and 210 cases, respectively. Patients in 2015-2020 group had higher parity than those in 2009-2014 group (1.2±1.2 vs 0.9±1.2, P=0.030). Nullípara (73 [41.2%] vs 65 [31.0%]) and primípara (71 [40.1%] vs 84 [40.0%]) were more frequently seen in 2009-2014 group than those in 2015-2020 group, but multípara (61 [29.0%] vs 33 [18.7%]) was more common in 2015-2020 group (P=0.028). For patients in 2015-2020 group, more patients demonstrated 1 or more metastases (107 [51.0%] vs 63 [35.6%], P=0.014) than those in 2009-2014 group. Patients in 2015-2020 group had more distant invasions affecting more organs, including lungs (76 [36.2%] vs 52 [29.4%]) and lungs combining with other organs (31 [14.8%] vs 11 [6.2%]), than those in 2009-2014 group (P=0.003).Conclusions: Although patients diagnosed with GTN between 2015 to 2020 is associated with higher parity, more children, and more distant metastases, we cannot simply conclude that clinical features of GTN has changed over time.
Hydrogen Peroxide Assisted Photocatalytic Dye Degradation Over Reduced Graphene Oxide Integrated ZnCr2O4 Nanoparticles
Authors: Tantubay Kartik , Das Piu , (Sen) Moni Baskey 
Published: September 2021

Abstract
Zinc chromite nanoparticles (NPs) and zinc chromite-reduced graphene oxide (ZnCr2O4-rGO) nanocomposite have been synthesized by the combined effect of reflux condensation and calcination process. The structural properties were characterised by X-ray diffraction (XRD), Fourier transform infrared (FTIR), UV-visible studies etc. Structural morphology was investigated by field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) that indicates the formation of particles in nanometre regime. The catalytic effects of synthesized materials were studied in presence of visible light assisted by hydrogen peroxide (H2O2) and they show excellent photo activity which supports the band gap value and photoluminescence outcome. The presence of the elements Zn, Cr, O and C has been confirmed by Energy dispersive X-ray spectroscopy (EDX) images which show the purity of the synthesized products.
Quantitatively characterizing sandy soil structure altered by microbial-induced carbonate precipitation （MICP） using multi-level thresholding segmentation on synchrotron radiation imaging
Authors: Liu Tao , Zhang Wei , Pan Xiaohua , Wang Jingtao , Deng Lu , Zhu Hong-hu 
Published: September 2021

Abstract
The influences of biological, chemical, and flow processes on soil structure through microbial-induced carbonate precipitation (MICP) are not yet fully understood. In this study, we use the Kapur entropy (KE) multi-level thresholding segmentation algorithm to quantitatively characterize sandy soil structure altered by MICP treatment. A sandy soil specimen was treated by MICP and scanned by the synchrotron radiation micro-CT with a resolution of 6.5 µm. After validation, tri-level thresholding segmentation using KE successfully separated the precipitated calcium carbonate crystals from sand particles and pores. Spatial distribution of porosity, pore structure parameters, and flow characteristics were calculated for quantitative characterization. The size effect of the specimen was discovered to be a key factor affecting the performance of MICP treated soil. The results offer pore-scale insights of MICP treatment effect, and the quantitative understanding confirms the importance of the KE multi-level thresholding segmentation algorithm.
Glutamyl-Prolyl tRNA Synthetase mRNA is Highly Expressed in Hepatocellular Carcinoma and May be Associated with Poor Prognosis
Authors: Shu Jinyong , Gao Yi , Zhang Guifeng , Luo Pan 
Published: September 2021

Abstract
BackgroundAlthough glutamyl-prolyl tRNA synthetase (EPRS) mRNA is overexpressed and plays an important role in most tumors, its role in the development and progression of hepatocellular carcinoma (HCC) remains unclear. MethodsThe expression of EPRS in tumor and adjacent tissues was queried using TIMER and The Cancer Genome Atlas. The results were validated using the real-time reverse transcription polymerase chain reaction on RNA extracted from tumor and adjacent non-tumor samples from 10 HCC patients.ResultsUsing bioinformatics analysis, we found that EPRS mRNA was overexpressed in HCC tumor tissues, and the expression level of EPRS mRNA in The Cancer Genome Atlas database was significantly correlated with tumor size (p = 0.0010), histological grade (p = 0.0002), TNM stage (p = 0.0001), and vascular invasion (p = 0.0123) of HCC. The Kaplan-Meier survival analysis demonstrated that the expression of EPRS mRNA was associated with poor overall survival (p = 0.0004). Ten pairs of tumor and adjacent normal tissues were collected from patients with HCC, and the expression of EPRS mRNA was verified. The results showed that the EPRS mRNA level in HCC tissues was higher than that in paracancerous tissues (p = 0.0401). ConclusionOverexpression of EPRS mRNA may be associated with tumorigenesis and the progression of HCC.