bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAJIAN POTENSI ANTIOKSIDAN ALAMI BERBAGAI LIMBAH TANAMAN
Authors: Lubis Rukiah , Hidayah Nur , Nopriyeni Nopriyeni 
Published: November 2021

Tujuan dari penelitian ini adalah untuk menganalisis kandungan antioksidan (antosianin, vitamin A, C, dan E) dari limbah kulit buah senduduk (Melastoma malabathricum L.), jantung pisang, jengkol. Penelitian dilaksanakan selama enam bulan. Analisa antosianin dan vitamin A, C, dan E dilakukan di Balai Besar Industri Agro, Bogor. Bahan yang digunakan pada penelitian ini terdiri dari kulit buah senduduk, jantung pisang, dan jengkol. Analisis kandungan vitamin A dilakukan pada sampel mengunakan alat High Performance Liquid Cromatography (HPLC). Penentuan kadar antosianin dihitung menggunakan metode perbedaan pH. Data yang diperoleh dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa aktivitas antioksidan alami yang paling tinggi menurut analisis kandungan vitamin A, C, E dan antosianin dari ketiga limbah tanaman (buah senduduk, jantung pisang, kulit jengkol), terdapat pada kulit buah senduduk dan kulit jantung pisang yaitu kandungan vitamin C (111.33 mg/kg dan 263.33 mg/kg) dan kandungan antosianin (684.008 mg/100g dan 174.289 mg/100g). Dapat disimpulkan bahwa buah senduduk dan jantung pisang bisa dijadikan sebagai antioksidan alami yang baik berdasarkan hasil analisis kandungan vitamin A, C, E, dan kandungan antosianin.THE STUDY OF POTENTIAL NATURAL ANTIOXIDANTS FROM PLANT WASTEThis study was aimed at analyzing the content of antioxidants (anthocyanins, vitamins A, C, and E) from the rind of sanduduk’s fruit (Melastoma malabathricum L.), Blossom of the banana plant (Musa acuminata Colla), jengkol (Archidendron pauciflorum) fruit. The research was conducted for six months. Analysis of anthocyanins and vitamins A, C, and E was performed at Balai Besar Industri Agro, Bogor. The materials used in this research consisted of sanduduk rind, banana blossom, and jengkol fruit. Vitamin A content analysis was performed on the samples using High Performance Liquid Chromatography (HPLC). The determination of anthocyanin levels was calculated using the pH difference method. The data obtained were analyzed descriptively. The results showed that the highest natural antioxidant activity according to the analysis of vitamin A, C, E and anthocyanin content from the three wastes, found in sanduduk rind and banana blossom which contain vitamin C ( 111.33 mg/kg and 263.33 mg/kg) and anthocyanin (684.008 mg/100g and 174.289 mg/100g). It can be concluded that sanduduk fruit and banana blossom can be used as a good natural antioxidant based on the results of analysis of vitamin A, C, E, and anthocyanin content.
A Norm-Creative Method for Co-constructing Personas With Children With Disabilities: Multiphase Design Study
Authors: Teleman Britta , Svedberg Petra , Larsson Ingrid , Karlsson Caroline , Nygren Jens M 
Published: November 2021

Background
An increase in the demand for child participation in health care requires tools that enable and empower children to be involved in the co-production of their own care. The development of such tools should involve children, but participatory design and research with children have challenges, in particular, when involving children with disabilities where a low level of participation is the norm. Norm-creative and participatory approaches may bring more effective design solutions for this group. “Personas” is a methodology for increasing user perspectives in design and offers representation when users are absent. However, research on participatory persona generation in this context is limited.

Objective
The objective of this study was to investigate how norm-creative and participatory design approaches can be integrated in a persona generation method to suit children with disabilities in the design of games for health that target this group.

Methods
The method development involved interview transcripts and image-based workshops. Sixteen children with various disabilities participated in persona generation through co-creation of characters and scenarios. The results from the workshops were validated together with 8 children without disabilities, 1 young adult with a disability, and 1 rehabilitation professional. A qualitative thematic design analysis was iterated throughout the process.

Results
The results consisted of an image-based and iterative co-construction method. It was accompanied by examples of personas that were generated and validated within a games for health case. The method showed effectiveness in enabling flexible co-construction and communication. The data resonated with social model perspectives, and the development is discussed in terms of participation levels, salutogenic descriptions of barriers, and norm-creative tradeoffs.

Conclusions
The resulting method may influence future design projects toward more inclusiveness and enable increased representation for children with disabilities in research and design. Using this method to its full potential requires a norm-critical awareness as well as extensive facilitation. Suggestions for further research include the application of the method to design processes in similar contexts or user groups.
Herbal Drugs with Anti-Diabetic Potential
Authors: Walia Smily , Dua J.S. , Prasad D.N. 
Published: November 2021

Diabetes mellitus (DM), also known as insulin-dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (NIDDM), is a common and serious metabolic condition that affects people all over the world. Traditional herbal plants have been utilized to treat diabetes mellitus all throughout the world. Several herbs have been found to treat and control diabetes among numerous medicines and poly herbal plants; they also have no adverse effects. Diabetes mellitus is a horrible disease that affects people all over the world and is becoming a serious danger to humanity's health. Thus, herbal plants may be a possible source of anti-diabetic medicines, with ethno botanical data indicating that around 800 plants may have anti-diabetic potential. Although synthetic oral hypoglycemic agents/insulin are a popular diabetes therapy and are effective in controlling hyperglycemia, they have significant side effects and do not significantly modify the course of diabetic complications. This is the primary reason why an increasing number of individuals are looking for alternative medicines with fewer or no adverse effects. The botanical name, common name, component, and mechanism of action for anti-diabetic activity were provided in this review study, as well as plant-based commercial poly herbal formulations.
Keywords: Diabetes mellitus, Medicinal plants, glucose, poly herbal plants
An overview of green synthesis mediated metal nanoparticles preparation and its scale up opportunities
Authors: Singh Anupama , Madhavi BLR , Nithin Sagar M N 
Published: November 2021

Nanoparticles in different field of science have a wide range of utility. They come in different forms. Among these, metal nanoparticles (MNP) have become an emerging tool for diagnostic as well as for therapeutic purposes. Metal nanoparticles are nano-sized particles made up of inorganic metals or their metal oxides. Various methods are available for the preparation/production of metal nanoparticles. In addition to the existing physical and chemical methods, green synthesis is an area that has drawn the attention of researchers in the decade and continues to be a potential area of research. The following review introduces about metal nanoparticles and discusses in details about the plant extract mediated metal nanoparticles synthesis, the principle of metal nanoparticle formation, various process parameters that are important for its synthesis, characterization of metal nanoparticles and the scope for commercialization are elaborated. Metal nanoparticles at research, employing plant extract mediated green synthesis have been extensively reviewed. This review tries to bring into light the feasibility of commercializing the green synthesis by using plant extracts.
Keywords: Green synthesis; Plant extract; One-step synthesis; Characterization; Process parameters; Scale-up
Chrysin and rutin protect against hydrogen peroxide and tert-butyl hydroperoxide induced oxidative cell damage
Authors: Ablassé Rouamba , Moussa Compaoré , Maurice Ouédraogo , Raoul Bationo , Martin Kiendrebeogo 
Published: November 2021

Objective: Chrysin and rutin are two dietary flavonoids lying in fruits or honey bee’s products. Their pharmacological properties include antioxidant, anti-inflammatory, anticancer, neuroprotection and immunomodulatory. In the current study, the potentiality of chrysin and rutin to protect human gingival fibroblasts against oxidative cell damage has been investigated in vitro.
Method: Human gingival fibroblasts, passage 3, were concomitantly put in contact with the cytotoxic compounds and chrysin or rutin for 24 h at 37 °C, 5% CO2 atmosphere, and 96% humidity. The amount of viable cell after the incubated time was recorded by using the thiazolyl blue tetrazolium bromide (MTT) assay.
Results: Chrysin in all tested concentration didn’t exhibit any cytoprotective effect against the tert-butyl hydroperoxide-induced oxidative cell damage. Moreover, chrysin in a low concentration (5 and 10 µg/mL) didn’t protect the fibroblasts against oxidative cell damage induced by the hydrogen peroxide. However, chrysin in a concentration of 20 µg/mL showed a significant cytoprotective activity in the hydrogen peroxide-induced cell damage (p < 0.05). Rutin in all tested concentrations protected fibroblasts against hydrogen peroxide and tert-butyl hydroperoxide-induced oxidative cell damage. The cytoprotective effect of rutin didn’t increase with the increase of the concentration when hydrogen peroxide is used to induce oxidative cell damage. However, rutin has protected cells against the tert-butyl hydroperoxide cytotoxicity in a concentration dependent manner.
Conclusion: Given to the interesting cytoprotective activities exhibited by chrysin and rutin, further investigations to highlight their cytoprotective involved mechanisms are justified.
Keywords: Chrysin, Cytoprotective, Fibroblasts, Rutin.
How does Heparan Sulfate and COVID-19 Work?: An Overview
Authors: Anna Alby , Sambath Kumar R , Venkateswaramurthy N 
Published: November 2021

Globally, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had infected over 3 million individuals and claimed many lives producing a global epidemic that necessitates the rapid development of therapeutic solutions. The ideal technique for quickly deploying well-characterized medicines against novel infections is known as drug repurposing. Several repurposable medicines are currently being tested to see if they may be used to treat COVID-19. Heparin, which is commonly utilized to reduce thrombotic events associated with COVID-19-induced disease, is one such promising drug. Heparansulphate is prevalently expressed in mammalian tissues. CoV-2 requires the helping cofactor heparansulphate (HS) on the cell surface: knocking down genes related in HS formation or treating cells with an HS mimic both prevent spike-mediated viral entrance. Heparin/HS binds directly to spike and promotes viral entrance by facilitating the attachment of spike-bearing viral particles to the cell surface. As documented with cell surface-bound heparansulphate, heparin binding to the open conformation of the spike structurally supports the state and may enhance ACE2 binding. Thus, heparansulphate could potentially be utilised to prevent SARS-CoV-2 transmission, based on available datas also consumption of heparansulphate during SARS-CoV-2 cellular entrance may play a role in the thrombotic events associated with COVID-19 infection. Furthermore, this study provides the findings on the mechanism(s) by which heparansulphate could slow the progression of SARS-CoV-2 infection.
Keywords: COVID-19, HeparanSulphate, Spike Protiens
Formulation and optimization of water soluble granules of Withania Somnifera
Authors: Tiwari Dilip Kumar , Mishra Kaushelendra , Mishra Neelima , Upmanyu Neeraj 
Published: November 2021

Herbal medicines have great demand in the treatment of various kinds of illness. Ayurvedic system of medicine has consisted of many herbal sources in which ashwagandha one of them which are the very popular herbal sources. Many literature surveys suggest that ashwagandha is used as an immunomodulator, tranquilizer, antioxidant, antidiabetic, and nootropic activity. Present research work explored the potential benefit of ashwagandha by designing suitable granules of its water extract. Further, it is characterized by various parameters and In-vitro drug release
Keywords: Immunomodulator, Tranquilizers Ayurvedic, Ashwagandha, Granules
Floating Drug Delivery System an Aid to Enhance Dissolution Profile of Gastric
Authors: YADAV SHALINI , YADAV SAURAV , KUMAR ASHUTOSH , MISHRA AMAR 
Published: November 2021

With the GRDDS, the dose shape remains controllably in the stomach after oral administration, so that the medication may be continually delivered to its absorption receptors in the intestinal tract. The medicine is delivering in a controlled and extended way. Gastro-retentive dose in the stomach area may last for another few hours and substantially lengthen the gastric residence period of the medicines. While the bulk density in the system for the supply of floating medicines (FDDS) exceeds the gastric fluids, it remains for an extended duration in the stomach without altering the rate of decomposition. The medication distributes gradually as the system floats on the stomach juice. As a consequence, stomach residency takes longer and plasma concentrations are well monitored. The therapy of peptic ulcer illness might be beneficial for local activity in the upper portion of the intestine, i.e., a longer stomach residency. In addition, medicines rapidly absorbed in the GI tract will increase bioavailability through delayed stomach release. The regulated gastric retention of solid dose forms can also be accomplished by the simultaneous administration of pharmacological agents, or by sedimentation, flotation processes, muco-adhesion, expansion, changed shape systems, by delaying the stomach emptying.
Keywords: Gastro-retentive drug delivery system, Floating drug delivery system, Muco-adhesion, Bioavailability.
Evaluation of Antiasthamic Activity of Electrohomeopathy Formulation Pettorale on Experimental Animals
Authors: Sabat Prasant Kumar 
Published: November 2021

Objective: The current study was planned to evaluate the antiasthamatic effect of Electrohomeopathic medicine Pettorale in various experimental models.
Methods: The antiasthmatic activity of Electrohomeopathic medicine Pettorale was studied on different experimental animals like histamine induced bronchospasm in guinea pig, haloperidol induced catalepsy in rats, egg albumin induced paw anaphylaxis in rats and milk induced leukocytosis in mice.
Conclusion: Preliminary phytochemical screening has revealed the presence of alkaloids, glycosides, carbohydrates, amino acids, proteins, steroids and terpenoids. Petorella exhibited best antihistaminic activity at the dose of 400 mg/kg. It inhibited haloperidol-induced catalepsy, increased leukocyte count and increased eosinophil count due to milk allergen. Antiasthmatic activity of Pettorale may be possible due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.
Keywords: Electrohomeopathy, Pettorale, catalepsy, asthma, histamine
Menopause Induced Depression, Anxiety, Quality of Life, Lack of Sleep in Women: An Overview
Authors: Ragasudha Arivazhagan , Minnu Skaria , Sambath Kumar R 
Published: November 2021

Background: Menopause occurs between the ages of 40 and 50, and marks the end of a woman's menstrual cycle. A period of time during which a woman does not have a monthly cycle for more than 12 months is known as post-menopause. Women may suffer challenges in their daily lives during this period, such as depression, anxiety, and sleep loss, all of which can have a negative impact on their quality of life. A decrease in hormone production, such as estrogen and progesterone, can cause menopause. To treat psychological difficulties in menopausal women, drugs such as vortioxetine and paroxetine, as well as selective serotonin reuptake inhibitors (SSRI) and anti-depressants, were advised.
Objective: To evaluate the effects in women how menopause inducing depression, anxiety, quality of life and lack of sleep.
Methodology: The recent studies related to the aim of the review were undertaken through a literature search to evaluate the effects in women how menopause inducing depression, anxiety, quality of life and lack of sleep.
Conclusion: Menopause, post-menopause, and peri-menopause are age-related causes in women who are going through the menstrual cycle. There is no need for medication during this time, but in severe cases, medications such as selective serotonin reuptake inhibitors (SSRI) and antidepressants should be administered and also for vaginal dryness and irritation Ospemifene is suggested. Many more clinical researches on the benefits of menopausal compilations will be needed in the future.
Keywords: Menopause, post- menopause, depression, estrogen, progesterone
Oferta turystyczna wsi tematycznych a potrzeby turystów na przykładzie wsi powiatu hrubieszowskiego
Authors: Sosnowska Małgorzata Anna , Iwanek Marcin 
Published: November 2021

Artykuł podejmuje problem zgodności oferty turystycznej wsi tematycznych z gustami i oczekiwaniami turystów pochodzących przede wszystkim ze środowisk miejskich. Przy wyborze wsi jako miejsca odpoczynku duże znaczenie dla współczesnego turysty ma jakość krajobrazu kulturowego wsi i zachowane elementy lokalnego dziedzictwa kulturowego. Jednak podczas kreowania oferty wsi tematycznych aspekt jakości i autentyczności zachowanego dziedzictwa kulturowego jest pomijany lub wykorzystywany w nikłym stopniu. W tym kontekście zadano pytania: jakie są postawy mieszkańców wsi oraz potencjalnych turystów wobec lokalnego dziedzictwa kulturowego, jakie oczekiwania mają potencjalni turyści wobec oferty turystycznej wsi i czy społeczność wiejska potrafi tym oczekiwaniom sprostać. Postawiono także pytanie: czy oferta i motywy wsi tematycznych w kształcie zaproponowanym przez mieszkańców trafią w gusta potencjalnych turystów. Celem badań była ocena zgodności pomiędzy oczekiwaniami turystów pochodzących głównie ze środowisk miejskich a ofertą turystyczną wsi tematycznych. W artykule rozważana jest hipoteza, że oferta turystyczna wsi tematycznych, których motyw oparto na lokalnym dziedzictwie kulturowym, jest dla odwiedzających i turystów bardziej atrakcyjna niż oferta oparta na motywie wykreowanym. W ramach badań przeprowadzonowywiady pogłębione z mieszkańcami wsi powiatu hrubieszowskiego, w których wyrażono zainteresowanie przystąpieniem do programu wsi tematycznych, a następnie pogłębiony wywiad kwestionariuszowy z mieszkańcami miast, czyli potencjalnymi turystami. Na podstawie badań stwierdzono, że oferta turystyczna kreowana przez mieszkańców wsi częściowo pokrywa się z gustami i potrzebami potencjalnych turystów pochodzących ze środowisk miejskich. Największe różnice pojawiają się w podejściu do możliwości adaptacji i zagospodarowania tradycyjnej zabudowy wiejskiej na cele turystyczne, która jest atrakcyjna dla turystów, ale budzi obawy mieszkańców wsi. Z badań wynika, że mieszkańcy miast oczekują atrakcyjnej oferty opartej na lokalnym dziedzictwie kulturowym.
Effects of dose of pyrophyllite on yield and quality of the cabbage
Authors: Govedarica-Lučić Aleksandra , Pašić Sanid , Jovović Mirjana , Rahimić Alma 
Published: November 2021

In this study was researched the influence of the pyrophyllite as a nutrient, bio-stabilizer, soil conditioner, as the adsorbent in different combinations and correlated standard quantitative relations with mineral fertilizers (NPK 15 : 15 : 15), on the yield and nutritional value of Bravo cabbage (Brassica oleraceae var. capitata). Within the examined factor of fertilization treatment, the following variances were represented: a1 – 800 kg ha–1 NPK 15 : 15 : 15 (control plot), a2 – 800 kg ha–1 NPK 15 : 15 : 15 + 2200 kg ha–1 pyrophyllite, a3 – 800 kg ha–1 NPK 15 : 15 : 15 + 1700 kg ha–1 of pyrophyllite, a4 – 800 kg ha–1 NPK 15 : 15 : 15 + 1200 kg ha–1 of pyrophyllite, a5 – 800 kg ha–1 NPK 15 : 15 : 15 + 700 kg ha–1 of pyrophyllite. The purpose of this research was to determine the extent to which the components of the yield and nutritional quality of cabbage depend on the different applied doses of pyrophyllite. The results indicate the fact that the treatments with the application of higher participation of pyrophyllite had a positive effect on the weight and quality of the cabbage head in relation to the control variance.
Magnetic resonance imaging features of large joint tuberculous arthritis
Authors: Agarwal Shalini , Mohan Lalit , Lamba Preeti , Kumar Sanjay 
Published: November 2021

Objectives:
Large joint monoarticular tuberculous involvement is rare. It may not be associated with classical clinical features. Hence, it is difficult to differentiate from other conditions similarly involving the large joints. Our study aimed to study the characteristics of large joint monoarthritis on magnetic resonance imaging.

Material and Methods:
We reviewed the radiology database for large joint tubercular arthritis cases over 2 years. In total, there were 21 patients. Male: female ratio was 11:10. The mean age was 34.14 ± 15.82 years with a range of 8–57 years. We diagnosed tuberculosis (TB) based on histopathological examination or response to antitubercular therapy.

Results:
Knee was most frequently involved (47%; n = 10) followed by wrist and elbow in 3 patients each (14.28%). Concomitant active pulmonary TB was absent in all of our patients. Grade I synovial thickening was seen in eight patients, Grade II in four, and Grade III in seven. It was uniform in all the cases. Grade 1 bone marrow edema was seen in 06 patients, Grade III in 13, and none in 02. There was soft-tissue edema in 12 patients and soft-tissue collection in 2. Bone erosions were seen in 16 patients with rim enhancement in nine patients. Central erosions were seen in eight, while central and peripheral erosions in eight. On T1-weighted images, the signal intensity was hyperintense 10 and isointense in 11 patients. While on T2-weighted images, it was hyperintense in 10, isointense in nine, and hypointense in two patients.

Conclusion:
Large joint monoarticular tuberculous arthritis can present variably. Large erosions with rim enhancement, the signal intensity of synovium on T1 weighted and T2 weighted, uniformity of synovial thickening, and enhancement pattern of abscesses can help make a diagnosis.