bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Performance Testing of a Novel In Vivo Laparoscope Lens Cleaning Device
Authors: Idelson Christopher , Uecker John , Garcia James A. , Kohli Sunjna , Handing Greta , Sriramprasad Vishrudh , Yong Kirstie , Rylander Christopher 
Published: April 2021

Abstract
A common tool for diagnosis and treatment of gastrointestinal, gynecologic, and other anatomical pathologies is a form of minimally invasive surgery known as laparoscopy. Roughly 4 × 106 laparoscopic surgeries are performed in the U.S. every year, with an estimated 15 × 106 globally. During surgeries, lens clarity often becomes impaired via (1) condensation or (2) smearing of bodily fluids and tissues. The current gold standard solution requires scope removal from the body for cleaning, offering opportunity for decreased surgical safety and efficiency, while simultaneously generating mounting frustration for the operating room team. A novel lens cleaning device was designed and developed to clean a laparoscope lens in vivo during surgery. Benchtop experiments in a warm body simulated environment allowed quantification of lens cleaning efficacy for several lens contaminants. Image analysis techniques detected the differences between original (clean), postdebris, and postcleaning images. Mechanical testing was also executed to determine safety levels regarding potential misuse scenarios. Compared to gold standard device technologies, the novel lens cleaning device prototype showed strong performance and ability to clear a laparoscope lens of debris while mitigating the need for scope removal from the simulated surgical cavity. Mechanical testing results also suggest the design also holds inherently strong safety performance. Both objective metrics and subjective observation suggests the novel design holds promise to improve safety and efficiency during laparoscopic surgery.
Numerical Analysis of the Kinematic Working Capability of Mechanisms
Authors: Yang Feng-Cheng , Haug Edward J. 
Published: April 2021

Abstract
An approach to numerical analysis of the kinematic dexterity of mechanisms is presented. Dextrous workspace problems are defined and illustrated. Composite workspaces are introduced to characterize both positioning and orienting capabilities of mechanisms. Using the composite workspace, numerical techniques for dextrous workspace analysis are presented. A numerical formulation and computer implementation that incorporates computer graphics and a numerical algorithm for solving systems of nonlinear equations are presented. Examples are given to illustrate the techniques developed.
Comparison Between Structural and Computational Decomposition in Parallel Processing of Design Optimization
Authors: El-Sayed Mohamed E. M. , Hsiung Ching-Kuo 
Published: April 2021

Abstract
This paper presents a comparison between two different approaches for parallel computation of structural optimization problems. The first approach decomposes the original structure into several substructures and assigns each substructure to one processor. Each processor handles the finite element calculation of its assigned substructure independently with limited communication between processors. The second approach decomposes the computation of constraint’s gradient evaluation. When a constraint’s gradient evaluation is needed the main processor decomposes it into several computation tasks, then assigns the computation tasks to the other available processors. To compare the speedup of the two approaches some numerical examples on the CRAY X-MP multi-processor system are presented.
The Metabolic Relevance of Type of Locomotion in Anaerobic Testing: Bosco Continuous Jumping Test Versus Wingate Anaerobic Test of the Same Duration
Authors: Kaufmann Sebastian , Hoos Olaf , Beck Aaron , Fueller Fabian , Latzel Richard , Beneke Ralph 
Published: April 2021

Purpose: To evaluate the metabolic relevance of type of locomotion in anaerobic testing by analyzing and comparing the metabolic profile of the Bosco Continuous Jumping Test (CJ30) with the corresponding profile of the Wingate Anaerobic Test (WAnT). Methods: A total of 11 well-trained, male team-sport athletes (age = 23.7 [2.2] y, height = 184.1 [2.8] cm, weight = 82.4 [6.4] kg) completed a CJ30 and WAnT each. During the WAnT, power data and revolutions per minute were recorded, and during the CJ30, jump height and jumping frequency were recorded. In addition, oxygen uptake and blood lactate concentration were assessed, and metabolic profiles were determined via the PCr-LA-O2 method. Results: In the CJ30, metabolic energy was lower (109.3 [18.0] vs 143.0 [13.1] kJ, P < .001, d = −2.302), while peak power (24.8 [4.4] vs 11.8 [0.5] W·kg−1, P < .001, d = 3.59) and mean power (20.8 [3.6] vs 9.1 [0.5] W·kg−1, P < .001, d = 4.14) were higher than in the WAnT. The metabolic profiles of the CJ30 (aerobic energy = 20.00% [4.7%], anaerobic alactic energy [WPCr] = 45.6% [4.5%], anaerobic lactic energy = 34.4% [5.2%]) and the WAnT (aerobic energy = 16.0% [3.0%], anaerobic alactic WPCr = 34.5% [5.0%], anaerobic lactic energy = 49.5% [3.3%]) are highly anaerobic. Absolute energy contribution for the CJ30 and WAnT was equal in WPCr (49.9 [11.1] vs 50.2 [11.2] kJ), but anaerobic lactic energy (37.7 [7.7] vs 69.9 [5.3] kJ) and aerobic energy (20.6 [5.7] vs 23.0 [4.0] kJ) were higher in the WAnT. Mechanical efficiency was substantially higher in the CJ30 (37.9% [4.5%] vs 15.6% [1.0%], P < .001, d = 6.86), while the fatigue index was lower (18.5% [3.8%] vs 23.2% [3.1%], P < .001, d = −1.38) than in the WAnT. Conclusions: Although the anaerobic share in both tests is similar and predominant, the CJ30 primarily taxes the WPCr system, while the WAnT more strongly relies on the glycolytic pathway. Thus, the 2 tests should not be used interchangeably, and the type of locomotion seems crucial when choosing an anaerobic test for a specific sport.
Asymptotic Justification of the Models of Thin Inclusions in an Elastic Body in the Antiplane Shear Problem
Authors: Rudoy E. M. , Itou H. , Lazarev N. P. 
Published: April 2021

Abstract
The equilibrium problem for an elastic body having an inhomogeneous inclusion with
curvilinear boundaries is considered within the framework of antiplane shear. We assume that
there is a power-law dependence of the shear modulus of the inclusion on a small parameter
characterizing its width. We justify passage to the limit as the parameter vanishes and construct
an asymptotic model of an elastic body containing a thin inclusion. We also show that, depending
on the exponent of the parameter, there are the five types of thin inclusions: crack, rigid inclusion,
ideal contact, elastic inclusion, and a crack with adhesive interaction of the faces. The strong
convergence is established of the family of solutions of the original problem to the solution of the
limiting one.
Experiences along the diagnostic pathway for patients with advanced lung cancer in the USA: a qualitative study
Authors: Al Achkar Morhaf , Zigman Suchsland Monica , Walter Fiona M , Neal Richard D , Goulart Bernardo H L , Thompson Matthew J 
Published: April 2021

BackgroundMost patients with lung cancer are diagnosed at advanced stages. However, the advent of oral targeted therapies has improved the prognosis of many patients with lung cancer.PurposeWe aimed to understand the diagnostic experiences of patients with advanced lung cancer with oncogenic mutations.MethodsQualitative interviews were conducted with patients with advanced or metastatic non-small cell lung cancer with oncogenic alterations. Patients were recruited from online support groups within the USA. Interviews were conducted remotely or in person. Analysis used an iterative inductive and deductive process. Themes were mapped to the Model for Pathways to Treatment.Results40 patients (12 male and 28 female) with a median age of 48 were included. We identified nine distinct themes. During the ‘patient interval’, individuals became concerned about symptoms, but often attributed them to other causes. Prolonged or more severe symptoms prompted care-seeking. During the ‘primary care interval’, doctors initially treated for illnesses other than cancer. Discovery of an imaging abnormality was a turning point in diagnostic pathways. Occasionally, severity of symptoms prompted patients to seek emergency care. During the ‘secondary care interval’, obtaining tissue samples was pivotal in confirming diagnosis. Delays in accessing oncology care sometimes led to patient distress. Obtaining genetic testing was crucial in directing patients to receive targeted treatments.ConclusionsPatients experienced multiple different routes to their diagnosis. Some patients perceived delays, inefficiencies and lack of coordination, which could be distressing. Shifting the stage of diagnosis of lung cancer to optimise the impact of targeted therapies will require concerted efforts in early detection.
Chronic headaches and middle meningeal artery embolization
Authors: Catapano Joshua S , Karahalios Katherine , Srinivasan Visish M , Baranoski Jacob F , Rutledge Caleb , Cole Tyler S , Ducruet Andrew F , Albuquerque Felipe C , Jadhav Ashutosh P 
Published: April 2021

BackgroundThe middle meningeal artery (MMA) has been implicated in chronic headaches, but no studies have examined the relationship between MMA embolization and headaches.MethodsPatients treated with MMA embolization for a chronic subdural hematoma (cSDH) between January 1, 2018, and December 31, 2020, were retrospectively assessed. Patients with a Glasgow Coma Scale (GCS) score of 15 at discharge received a follow-up telephone call to assess their history of chronic headache, defined as a headache ≥2 years before the cSDH and symptoms ≥2 days/month. A Headache Impact Test (HIT-6) was performed during the follow-up telephone call. The primary outcome was resolution or improvement of headaches after embolization.ResultsOf 76 patients undergoing MMA embolization for a cSDH during the study period, 56 (74%) had a discharge GCS score of 15. Of these 56 patients, 46 (82%) responded to a follow-up telephone call and were analyzed (mean [SD] age 68 [11] years; 36 [78%] men and 10 [22%] women). Nine (20%) reported chronic headaches before embolization. With a mean (SD) follow-up of 489 (173) days, eight of the nine patients reported improvement of chronic headaches, with seven having complete resolution. For these nine patients, the mean (SD) HIT-6 score was significantly higher before embolization than after embolization (64 [7.1] vs 40 [9.1], p<0.001).ConclusionIn patients with chronic headaches who underwent MMA embolization for a cSDH, the majority reported improvement of headaches after the procedure. Future prospective studies are warranted to assess the usefulness of MMA embolization to treat chronic headaches.
On the l.c.m. of shifted Fibonacci numbers
Authors: Sanna Carlo 
Published: April 2021

Let [Formula: see text] be the sequence of Fibonacci numbers. Guy and Matiyasevich proved that [Formula: see text] where lcm is the least common multiple and [Formula: see text] is the golden ratio. We prove that for every periodic sequence [Formula: see text] in [Formula: see text] there exists an effectively computable rational number [Formula: see text] such that [Formula: see text] Moreover, we show that if [Formula: see text] is a sequence of independent uniformly distributed random variables in [Formula: see text] then [Formula: see text] where [Formula: see text] is the dilogarithm function.
On the Use of Multi-sensory Cues in Symmetric and Asymmetric Shared Collaborative Virtual Spaces
Authors: Jung Sungchul , Karki Nawam , Slutter Max , Lindeman Robert W. 
Published: April 2021

Physical face-to-face collaboration with someone gives a higher-quality experience compared to mediated communication options, such as a phone- or video-based chat. Participants can share rich sensory cues to multiple human senses in a physical space. Also, the perceptual sensing of the surrounding environment including other peoples' reactions can influence human communication and emotion, and thus collaborative performance. Shared spaces in virtual environments provide degraded sensory experiences because most commercial virtual reality systems typically provide only visual and audio feedback. The impact of richer, multi-sensory feedback on joint decision-making tasks in VR is still an open area of research. Two independent studies exploring this topic are presented in this paper. We implemented a multi-sensory system that delivers vision, audio, tactile, and smell feedback, and we compared the system to a typical VR system. The scenario placed two users in a virtual theme-park safari ride with a number of non-player character (NPC) passengers to simulate realistic scenarios compared to the real-world and we varied the type and complexity of NPCs reactions to participants.
In Experiment 1, we provided both users with either multi-sensory or typical sensory feedback symmetrically as a between-subjects factor, and used NPC reaction type as a within-subjects factor. In Experiment 2, we provided sensory feedback asymmetrically to each user (i.e., one had multi-sensory cues and the other had typical sensory cues) as a between-subjects factor, and used NPC reaction type as a within-subjects factor. We found that the number of sensory channels and NPC reactions did not influence user perception significantly under either symmetric or asymmetric sensory feedback conditions. However, after accounting for individual personality traits (e.g., assertive, passive), as well as any existing relationship between the pairs, we found that increasing the number of sensory channels can significantly improve subjective responses.
The Complementary Nature of Perceived and Actual Time Spent Online in Measuring Digital Well-being
Authors: Mok Lillio , Anderson Ashton 
Published: April 2021

As online platforms become ubiquitous, there is growing concern that their use can potentially lead to negative outcomes in users' personal lives, such as disrupted sleep and impacted social relationships. A central question in the literature studying these problematic effects is whether they are associated with the amount of time users spend on online platforms. This is often addressed by either analyzing self-reported measures of time spent online, which are generally inaccurate, or using objective metrics derived from server logs or tracking software. Nonetheless, how the two types of time measures comparatively relate to problematic effects -- whether they complement or are redundant with each other in predicting problematicity -- remains unknown. Additionally, transparent research into this question is hindered by the literature's focus on closed platforms with inaccessible data, as well as selective analytical decisions that may lead to reproducibility issues.
In this work, we investigate how both self-reported and data-derived metrics of time spent relate to potentially problematic effects arising from the use of an open, non-profit online chess platform. These effects include disruptions to sleep, relationships, school and work performance, and self-control. To this end, we distributed a gamified survey to players and linked their responses with publicly-available game logs. We find problematic effects to be associated with both self-reported and data-derived usage measures to similar degrees. However, analytical models incorporating both self-reported and actual time explain problematic effects significantly more effectively than models with either type of measure alone. Furthermore, these results persist across thousands of possible analytical decisions when using a robust and transparent statistical framework. This suggests that the two methods of measuring time spent measure contain distinct, complementary information about problematic usage outcomes and should be used in conjunction with each other.
Utilizing Web Trackers for Sybil Defense
Authors: Flores Marcel , Kahn Andrew , Warrior Marc , Mislove Alan , Kuzmanovic Aleksandar 
Published: April 2021

User tracking has become ubiquitous practice on the Web, allowing services to recommend behaviorally targeted content to users. In this article, we design Alibi, a system that utilizes such readily available personalized content, generated by recommendation engines in real time, as a means to tame Sybil attacks. In particular, by using ads and other tracker-generated recommendations as implicit user “certificates,” Alibi is capable of creating meta-profiles that allow for rapid and inexpensive validation of users’ uniqueness, thereby enabling an Internet-wide Sybil defense service.
We demonstrate the feasibility of such a system, exploring the aggregate behavior of recommendation engines on the Web and demonstrating the richness of the meta-profile space defined by such inputs. We further explore the fundamental properties of such meta-profiles, i.e., their construction, uniqueness, persistence, and resilience to attacks. By conducting a user study, we show that the user meta-profiles are robust and show important scaling effects. We demonstrate that utilizing even a moderate number of popular Web sites empowers Alibi to tame large-scale Sybil attacks.
Performance Evaluation of Intel Optane Memory for Managed Workloads
Authors: Akram Shoaib 
Published: April 2021

Intel Optane memory offers non-volatility, byte addressability, and high capacity. It suits managed workloads that prefer large main memory heaps. We investigate Optane as the main memory for managed (Java) workloads, focusing on performance scalability. As the workload (core count) increases, we note Optane’s performance relative to DRAM. A few workloads incur a slight slowdown on Optane memory, which helps conserve limited DRAM capacity. Unfortunately, other workloads scale poorly beyond a few core counts.
This article investigates scaling bottlenecks for Java workloads on Optane memory, analyzing the application, runtime, and microarchitectural interactions. Poorly scaling workloads allocate objects rapidly and access objects in Optane memory frequently. These characteristics slow down the mutator and substantially slow down garbage collection (GC). At the microarchitecture level, load, store, and instruction miss penalties rise. To regain performance, we partition heaps across DRAM and Optane memory, a hybrid that scales considerably better than Optane alone. We exploit state-of-the-art GC approaches to partition heaps. Unfortunately, existing GC approaches needlessly waste DRAM capacity because they ignore runtime behavior.
This article also introduces performance impact-guided memory allocation (PIMA) for hybrid memories. PIMA maximizes Optane utilization, allocating in DRAM only if it improves performance. It estimates the performance impact of allocating heaps in either memory type by sampling. We target PIMA at graph analytics workloads, offering a novel performance estimation method and detailed evaluation. PIMA identifies workload phases that benefit from DRAM with high (94.33%) accuracy, incurring only a 2% sampling overhead. PIMA operates stand-alone or combines with prior approaches to offer new performance versus DRAM capacity trade-offs. This work opens up Optane memory to a real-life role as the main memory for Java workloads.
Association of Blood Pressure Classification Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Risk of Heart Failure and Atrial Fibrillation
Authors: Kaneko Hidehiro , Yano Yuichiro , Itoh Hidetaka , Morita Kojiro , Kiriyama Hiroyuki , Kamon Tatsuya , Fujiu Katsuhito , Michihata Nobuaki , Jo Taisuke , Takeda Norifumi , Morita Hiroyuki , Node Koichi , Carey Robert M. , Lima Joao A.C. , Oparil Suzanne , Yasunaga Hideo , Komuro Issei 
Published: April 2021

Background:
Heart failure (HF) and atrial fibrillation (AF) are growing in prevalence worldwide. Few studies have assessed to what extent stage 1 hypertension in the 2017 American College of Cardiology/American Heart Association blood pressure (BP) guidelines is associated with incident HF and AF.

Methods:
Analyses were conducted with a nationwide health claims database collected in the JMDC Claims Database between 2005 and 2018 (n=2 196 437; mean age, 44.0±10.9 years; 58.4% men). No participants were taking antihypertensive medication or had a known history of cardiovascular disease. Each participant was categorized as having normal BP (systolic BP <120 mm Hg and diastolic BP <80 mm Hg; n=1 155 885), elevated BP (systolic BP 120–129 mm Hg and diastolic BP <80 mm Hg; n=337 390), stage 1 hypertension (systolic BP 130–139 mm Hg or diastolic BP 80–89 mm Hg; n=459 820), or stage 2 hypertension (systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg; n=243 342). Using Cox proportional hazards models, we identified associations between BP groups and HF/AF events. We also calculated the population attributable fractions to estimate the proportion of HF and AF events that would be preventable if participants with stage 1 and stage 2 hypertension were to have normal BP.

Results:
Over a mean follow-up of 1112±854 days, 28 056 incident HF and 7774 incident AF events occurred. After multivariable adjustment, hazard ratios for HF and AF events were 1.10 (95% CI, 1.05–1.15) and 1.07 (95% CI, 0.99–1.17), respectively, for elevated BP; 1.30 (95% CI, 1.26–1.35) and 1.21 (95% CI, 1.13–1.29), respectively, for stage 1 hypertension; and 2.05 (95% CI, 1.97–2.13) and 1.52 (95% CI, 1.41–1.64), respectively, for stage 2 hypertension versus normal BP. Population attributable fractions for HF associated with stage 1 and stage 2 hypertension were 6.1% (95% CI, 5.4%–6.8%) and 11.9% (95% CI, 11.5%–12.4%), respectively. The population attributable fractions for AF associated with stage 1 and stage 2 hypertension were 5.1% (95% CI, 3.4%–6.7%) and 7.5% (95% CI, 6.4%–8.6%), respectively.

Conclusions:
Both stage 1 hypertension and stage 2 hypertension were associated with a greater incidence of HF and AF in the general population. The American College of Cardiology/American Heart Association BP classification system may help identify adults at higher risk for HF and AF events.
Thank Goodness for the Atmosphere: Reflections on the Starry Sky and the Moral Law
Authors: Schmidt Dennis J. 
Published: April 2021

Abstract
The purpose of this article is to take up the largely unthought challenge of Kant’s celebrated remark about how “two things”—the starry sky above and the moral law within—fill the mind with wonder the more one reflects upon them. After briefly discussing the role of the image of the stars in early Greek thought, and then taking account of what we know about the heavens today, I ask if we have yet come to understand just what our relation to the heavens means. The conclusion is that taking the image of the stars seriously and making the effort to understand what we see in that image humbles us. It brings us before a profound limit regarding our understanding of what it means to be human and what it means to live on the earth.
Frantz Fanon’s Engagement with Phenomenology: Unlocking the Temporal Architecture of Black Skin, White Masks
Authors: Bernasconi Robert 
Published: April 2021

Abstract
Attention to the role of phenomenology in Frantz Fanon’s Black Skin, White Masks is fundamental to an appreciation of the book’s progressive structure. And it is through an appreciation of this structure that it becomes apparent that the book’s engagement with phenomenology amounts to an enrichment, not a critique, of existential phenomenology, although the latter might appear to be the case at first sight, given Fanon’s rejection of certain aspects of Jean-Paul Sartre’s “Black Orpheus.” This is demonstrated through an examination of Fanon’s references to Sartre, Günther Anders, and Maurice Merleau-Ponty in the book’s final crucial pages on temporality. His largely neglected relation to Karl Jaspers and the concept of historicity is also explored.