bluuebunny/crossref_metadata_2025_split huggingface dataset:
CANDLE Syndrome: Case Report of a Rare Type of Auto- Inflammatory Disease
Authors: Ali Md Asif , Islam Mohammad Imnul , Rahman Shahana Akhtar 
Published: March 2021

CANDLE syndrome (chronic atypical neutophilic dermatosis with lipodystrophy and elevated temperature) is an autoinflammatory disease/syndrome characterized by recurrent fever, skin lesions, and multisystem inflammatory manifestations. Most of the patients have shown mutation in PSMB8 gene. Here, we report a 9-year-old girl with recurrent fever, atypical facies, widespread skin lesions, generalized lymphadenopathy, hepato-splenomegaly, lipodystrophy, and failure to thrive. Considering the clinical features and laboratory investigations including skin biopsy findings, diagnosis was consistent with CANDLE syndrome. Therefore, it is recommended to consider CANDLE syndrome in a young child who presents with recurrent fever, characteristics rashes, organomegaly and failure to thrive.
Bangladesh J Child Health 2020; VOL 44 (3) :174-177
Neonatal COVID-19 in A Tertiary Care Hospital of Chattogram: A Case Report
Authors: Das Jagadish C , Khan Md Masudur Rahaman , Ferdous Jannatul , Mohammed Shaheen - , Hasan Syeda Humaida 
Published: March 2021

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China in December 2019 and now has led to a global pandemic. The incidence is lower in neonates. A five days old newborn infant got admitted with history of reluctance to feeding and less movement. On admission, the newborn infant was found to be lethargic, icteric, tachypnoeic, afebrile with SPO2 of 90% throughout his hospital stay. Chest x-ray was normal but RT-PCR for COVID-19 was positive. His mother had symptoms of COVID-19 with positive RTPCR. The neonate was isolated and was treated with antibiotics along with supportive care, then improved gradually and was discharged on day 10 of his age. Suspicion about COVID-19 in newborn infants with prompt identification is essential to limit its transmission in the community.
Bangladesh J Child Health 2020; VOL 44 (3) :170-173
Nephrotic Range of Proteinuria in Congenital Cyanotic Heart Disease: A Rare Complication
Authors: Sultana Azmeri , Chowdhury Naharuma Aive Hyder , Hossain Jesmin , Kabir Shahreen , Islam Md Shahidul 
Published: March 2021

Nephrotic syndrome is a common renal problem in children. But it is an uncommon complication for cyanotic heart diseases. It has been rarely reported in pediatric population with congenital cyanotic heart disease in Bangladesh. We found two cases of congenital cyanotic heart disease those were referred to investigate for nephrotic range of proteinuria.
Bangladesh J Child Health 2020; VOL 44 (3) :178-180
Analisis Keterampilan Berpidato Siswa Kelas IV SD Negeri 188 Pekanbaru
Authors: Iskandar Zulkarnain Gunawan  , Otang Kurniaman  , Zufriady  
Published: March 2021

The background of this research is that speaking skills are one aspect of language skills that students must master, in addition to the three other skills, namely reading, listening and writing. Learning to Speak in Elementary School which is given through Indonesian Language subjects. Although learning to Speak has been recognized as an important part of learning Indonesian in elementary schools, in fact speaking learning has received less attention from teachers and students. One of the speaking skills that needs to be asked is the skill in making a speech. For that reason, the researcher conducted a research that aimed to describe the skills of students in grade IV at State of Elementary School 188 Pekanbaru. This research is a descriptive quantitative research conducted at State of Elementary School 188 Pekanbaru with 80 students as research subjects. The instrument used to collect data was the student sample sheet test which contains indicators in making speeches. The results showed that students who got the very skilled category were 17.05%. In the skilled category as much as 31.25%. In the sufficiently skilled category as much as 50%. The students' skills are in the skilled category with an average score of 78.05.

[Latar belakang penelitian ini adalah Keterampilan berbicara merupakan salah satu aspek keterampilan berbahasa yang harus dikuasai siswa, selain ketiga keterampilan lain yaitu membaca, menyimak dan menulis. Pembelajaran berbicara di Sekolah Dasar diberikan melalui mata pelajaran Bahasa Indonesia. Meskipun pembelajaran berbicara telah disadari merupakan bagian penting dalam pembelajaran Bahasa Indonesia di Sekolah Dasar, namun pada kenyataannya pembelajaran berbicara kurang mendapat perhatian dari guru maupun siswa. Salah satu contoh keterampilan berbicara yang perlu di perhatikan adalah keterampilan dalam berpidato untuk itu peneliti melakukan penelitian yang bertujuan untuk mengetahui serta mendeskripsikan keterampilan siswa dalam berpidato di kelas IV di SEKOLAH DASAR Negeri 188 Pekanbaru. Penelitian ini merupakan penelitian kuantitatif deskriptif yang dilakukan di Sekolah Dasar Negeri 188 Pekanbaru dengan subjek penelitian sebanyak 80 siswa. Instrumen yang digunakan untuk mengumpulkan data adalah tes lembar penilaian siswa yang berisikan indikator dalam berpidato. Hasil penelitian ini menunjukan bahwa siswa yang mendapatkan kategori sangat terampil sebanyak 17.05%. Pada kategor terampil sebanyak 31,25%. Pada kategori cukup terampil sebanyak 50%. Umumnya keterampilan berpidato siswa berada pada kategori terampil dengan nilai rata-rata 78,05]
Analisis Pengelolaan Dana Bantuan Khusus Guru (BKG) Diniyah di Kabupaten Bandung Barat
Authors: Salamah Syifa , Andriani Safitri Nita , Nurlatifah  , Hidayat Ara 
Published: March 2021

The aim of this research is to analyze and study the practice of managing the Special Assistance fund in Diniyah Takmiliyah Communication Forum in West Bandung Regency. This research is a descriptive research with a qualitative approach. The data collection technique is done by interview, observation, and literature study. Literature study by seeking information from other literature. The data obtained were then analyzed by reducing, presenting, and concluding. The analysis results of the management the Special Assistance fund At Madrasah Diniyah Takmiliyah Awaliyah Al-Alim was found that: (1) The Special Assistance Fund for Madrasah Diniyah Takmiliyah Awaliyah Teachers was sourced from the allocation of grants distributed by the provincial government in collaboration with the “Majelis Kerja Kelompok Diniyah Takmiliyah” (MK2DT). Then the funds are managed by the “Forum Komunikasi Madrasah Diniyah Takmiliyah” (FKDT) at the district or city level which is then coordinated with the FKDT at the sub-district level before being received directly by each teacher in each MDTA educational institution; (2) The management of the BKG funds has shown the principles of efficiency and tolerance in the budget allocation for costs.

[Tujuan penelitin ini untuk menganalisis dan mengkaji praktik pengelolaan dana bantuan khusus guru (BKG) pada Forum Komunikasi Diniyah Takmiliyah di Kabupaten Bandung Barat. Penelitian ini merupakan jenis penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan dengan wawancara, observasi, dan studi pustaka. Studi Pustaka dilakukan dengan mencari informasi dari literatur lainya. Data yang diperoleh kemudian dianalisis dengan cara direduksi, disajikan, dan disimpulkan. Hasil analisis pengelolaan Dana Bantuan Khusus Guru (BKG) di Madrasah Diniyah Takmiliyah Awaliyah Al-Alim diperoleh bahwa: (1) Dana Bantuan Khusus Guru Madrasah Diniyah Takmiliyah Awaliyah bersumber dari alokasi dana Hibah yang disalurkan oleh pemerintah Provinsi berkerjasama dengan Majelis Kerja Kelompok Diniyah Takmiliyah (MK2DT) Jawa Barat. Kemudian dana tersebut dikelola oleh Forum Komunikasi Madrasah Diniyah Takmiliyah (FKDT) tingkat kabupaten atau kota yang kemudian di koordinasikan dengan FKDT tingkat kecamatan sebelum diterima langsung oleh masing-masing guru disetiap lembaga pendidikan MDTA; (2) Pengelolaan anggaran biaya dana bantuan khusus guru sudah menunjukan prinsip efesiensi dan toleransi dalam alokasi anggaran biaya]
Transposição do conhecimento científico no ensino de Matemática para cegos
Authors: Simões Guilherme Soares , Silva Rafael Soares , Amaral Carmem Lúcia Costa 
Published: March 2021

Esse estudo teve como objetivo investigar os desafios e potencialidades na transposição da linguagem científica no ensino de matemática para alunos com deficiência visual. A pesquisa possui uma abordagem qualitativa e como forma de apropriação e percepção de temas elementares para a efetivação do estudo realizou-se uma revisão de literatura. Na ausência da visão meios alternativos devem ser utilizados a fim de favorecer a familiarização com as ciências e a construção do conhecimento de maneira semelhante aos demais alunos. Constatou-se que existe uma dificuldade na transposição do conhecimento científico para o conhecimento escolar devido, sobretudo, a inexistência de manuais específicos de como realizá-las de maneira satisfatória, devido a especificidade da linguagem científica. Soma-se a esta ausência a falta de preparo dos professores, das escolas, e a carência de materiais pedagógicos adaptados como desafios a serem superados a fim de transpor a linguagem científica para as pessoas com diferentes necessidades de aprendizagem
A dimensão afetiva no processo de alfabetização de jovens e adultos
Authors: Silva Joselia Cristina Siqueira da , Bianco Gilmene , Silveira Dieison Prestes da , Gomes Rodrigo Da Vitória , Da Veiga Deivid Jonas Silva , Scheffer Denise da Costa Dias 
Published: March 2021

A afetividade tem um papel importante no processo de aprendizagem do ser humano. Com o auxílio da afetividade, docentes e educandos conseguem criar laços de amizade entre si. A mesma potencializa o ser humano a revelar os seus sentimentos em relação a outros seres e objetos. Partindo desses pressupostos, o presente artigo tem por objetivo discorrer uma análise sobre a importância do aspecto afetivo e da interação social vivenciada pelos jovens e adultos em sala de aula durante o processo de alfabetização. Esta pesquisa apresenta metodologia de natureza qualitativa dentro de uma perspectiva bibliográfica exploratória, no qual os dados denotados foram analisados com base na perspectiva do Método da Análise Documental, que constitui na extração de elementos informativos de um documento original a fim de expressar seu conteúdo de forma abreviada, resultando na conversão de um documento primário em documento secundário. Nos dados obtidos infere-se que as relações estabelecidas em sala de aula constituem um dos momentos mais significativos para a expressão da afetividade, contribuindo, assim, para o desenvolvimento da constituição do aluno como pessoa.
Implementation and Evaluation of Virtual Anticoagulation Clinic Care to Provide Incessant Care During COVID-19 Times in an Indian Tertiary Care Teaching Hospital
Authors: Shambu Sunil Kumar , B Shyam Prasad Shetty , Gona Oliver Joel , Desai Nagaraj , B Madhu , Madhan Ramesh , V Revanth 
Published: March 2021

Background: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-II) has become a global pandemic disrupting public health services. Telemedicine has emerged as an important tool to deliver care during these situations. Patients receiving Vitamin K antagonists (VKA) require structured monitoring which has posed a challenge during this pandemic. We aimed to evaluate the impact of Virtual anticoagulation clinic (VAC), a Telehealth model on the quality of anticoagulation, adverse events, and patient satisfaction vis-a-vis standard Anticoagulation clinic (ACC) care.Materials and methods: A bidirectional cohort study was conducted in the Department of Cardiology, JSS Hospital, Mysore. Two hundred and twenty-eight patients in the VAC and 274 patients in the ACC fulfilling inclusion criteria were the subjects of the study. Telehealth tools like WhatsApp and telephone were used. Time in therapeutic range (TTR), Percentage of International normalized ratio in range (PINRR), and adverse events were analyzed and compared between the VAC group and the ACC group, between pre-COVID and COVID ACC groups, and between the VAC group and the same pre-COVID cohort. Patient satisfaction was assessed by a questionnaire at the end of 8 months. Descriptive statistics were used for the patient characteristics and inferential statistics for the comparisons between pre-VAC and VAC care.Results: The mean TTR was 75.4 ± 8.9% and 71.2 ± 13.4% in the VAC group and ACC group, respectively (p &lt; 0.001). The mean PINRR was 66.7 ± 9.4% and 62.4 ± 10.9% in the VAC group and ACC group respectively, (p &lt; 0.001). There was no significant difference in TTR between the VAC group and the same pre-COVID cohort. The TTR differential between the pre-COVID and COVID ACC groups was significant. In either group, no major adverse events were seen. The most common tools used for data exchange were WhatsApp (83%) and SMS (17%). Seventy-four percent of patients were extremely satisfied with the overall VAC care.Conclusions: Virtual anticoagulation clinic, a telehealth model can be used as an alternative option to deliver uninterrupted anticoagulation care during pandemic times.
Serum 8-iso-PGF2α Predicts the Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study
Authors: Zheng Ling , Fei Jun , Feng Chun-Mei , Xu Zheng , Fu Lin , Zhao Hui 
Published: March 2021

Background: Many studies have identified the important role of 8-isoprostane (8-iso-PGF2α) in pulmonary diseases. However, the role of 8-iso-PGF2α in community-acquired pneumonia (CAP) remains unclear. Therefore, the main goal was to investigate the correlations of serum 8-iso-PGF2α with the severity and prognosis in CAP patients through a hospital-based retrospective cohort study.Methods: All 220 patients with CAP were enrolled. Demographic information and clinical data were collected. Levels of 8-iso-PGF2α and inflammatory cytokines were detected in serum using ELISA.Results: The levels of 8-iso-PGF2α were gradually increased in parallel with the CAP severity scores. Univariate and multivariate logistic regression analyses revealed a positive association between serum 8-iso-PGF2α and the CAP severity scores. Additionally, serum 8-iso-PGF2α levels were positively correlated with circulating inflammatory cytokines (CRP and TNFα). Serum 8-iso-PGF2α levels were increased in the patients with a longer hospital stay than those with a shorter hospital stay. Additionally, 20 patients died after hospitalization. Dead patients presented a higher serum 8-iso-PGF2α than surviving patients. A subsequent survival analysis revealed that higher serum 8-iso-PGF2α levels positively correlated with the risk of death in patients with CAP.Conclusions: Serum 8-iso-PGF2α levels on admission are positively associated with the severity of CAP patients. Elevated serum 8-iso-PGF2α on admission prolongs hospital stay and increases the risk of death in patients with CAP, indicating that 8-iso-PGF2α may be involved in the progression of CAP and serve as an early serum prognostic biomarker for CAP.
Serum Metabolomic Analysis of Chronic Drug-Induced Liver Injury With or Without Cirrhosis
Authors: Chen Shuai-shuai , Huang Ying , Guo Yu-ming , Li Shan-shan , Shi Zhuo , Niu Ming , Zou Zheng-sheng , Xiao Xiao-he , Wang Jia-bo 
Published: March 2021

Background: Chronic drug-induced liver injury (DILI) occurs in up to 20% of all DILI patients. It presents a chronic pattern with persistent or relapsed episodes and may even progress to cirrhosis. However, its underlying development mechanism is poorly understood.Aims: To find serum metabolite signatures of chronic DILI with or without cirrhosis, and to elucidate the underlying mechanism.Methods: Untargeted metabolomics coupled with pattern recognition approaches were used to profile and extract metabolite signatures from 83 chronic DILI patients, including 58 non-cirrhosis (NC) cases, 14 compensated cirrhosis (CC) cases, and 11 decompensated cirrhosis (DC) cases.Results: Of the 269 annotated metabolites associated with chronic DILI, metabolic fingerprints associated with cirrhosis (including 30 metabolites) and decompensation (including 25 metabolites), were identified. There was a significantly positive correlation between cirrhosis-associated fingerprint (eigenmetabolite) and the aspartate aminotransferase-to-platelet ratio index (APRI) (r = 0.315, P = 0.003). The efficacy of cirrhosis-associated eigenmetabolite coupled with APRI to identify cirrhosis from non-cirrhosis patients was significantly better than APRI alone [area under the curve (AUC) value 0.914 vs. 0.573]. The decompensation-associated fingerprint (eigenmetabolite) can effectively identify the compensation and decompensation periods (AUC value 0.954). The results of the metabolic fingerprint pathway analysis suggest that the blocked tricarboxylic acid cycle (TCA cycle) and intermediary metabolism, excessive accumulation of bile acids, and perturbed amino acid metabolism are potential mechanisms in the occurrence and development of chronic DILI-associated cirrhosis.Conclusions: The metabolomic fingerprints characterize different stages of chronic DILI progression and deepen the understanding of the metabolic reprogramming mechanism of chronic DILI progression to cirrhosis.
Quality of Life in SMA Patients Under Treatment With Nusinersen
Authors: Mix Lucas , Winter Benedikt , Wurster Claudia D. , Platen Sophia , Witzel Simon , Uzelac Zeljko , Graf Heiko , Ludolph Albert C. , Lulé Dorothée 
Published: March 2021

Background:Spinal Muscular Atrophy (SMA) is a severe neurodegenerative disease, characterized by progressive muscle weakness and atrophy. The approval of the antisense oligonucleotide (ASO) nusinersen now provides an effective pharmacological approach with the potential to slow down or stop disease progression with a potentially major impact on patients' well-being.Objective:This study evaluates quality of life (QoL) in pediatric and adult patients over the course of therapy with nusinersen.Methods:Twenty-six SMA patients treated with nusinersen were evaluated regarding global QoL (gQoL), health-related QoL (HRQoL) and depressiveness. Assessments were conducted three times over the first 6 months of treatment. Applied were different questionnaires: the Anamnestic Comparative Self-Assessment (ACSA) for gQoL, the Short Form-36 Health Survey (SF-36) for HRQoL in adult patients and the ALS Depression Inventory 12 Items (ADI-12) for depressiveness. The sample was matched with 22 healthy controls.Results:Despite severe physical restrictions, patients reported high levels of QoL and low levels of depressiveness at study entry. Early disease onset and low levels of physical functioning were associated with better gQoL and lower levels of depressiveness. A significant decrease of gQoL in patients was evident over the course of the study. Still, adult patients reported a significant increase in perceived health.Conclusions:Our study provides first insight that SMA patients experience a gQoL superior to healthy controls at start of therapy. This might indicate patients' high hopes and expectations toward treatment. gQoL returns to a level similar to that of healthy controls over the course of therapy.
Attenuation of Hippocampal Evoked Potentials in vivo by Activation of GtACR2, an Optogenetic Chloride Channel
Authors: Acharya Anirudh R. , Larsen Lars Emil , Van Lysebettens Wouter , Wadman Wytse Jan , Delbeke Jean , Vonck Kristl , Meurs Alfred , Boon Paul , Raedt Robrecht 
Published: March 2021

AimGtACR2, a light-activated chloride channel, is an attractive tool for neural inhibition as it can shunt membrane depolarizations. In this study, we assessed the effect of activating GtACR2 on in vivo hippocampal CA1 activity evoked by Schaffer collateral (SC) stimulation.MethodsAdult male Wistar rats were unilaterally injected with 0.5 μL of adeno associated viral vector for induction of GtACR2-mCherry (n = 10, GtACR2 group) or mCherry (n = 4, Sham group) expression in CA1 pyramidal neurons of the hippocampus. Three weeks later, evoked potentials (EPs) were recorded from the CA1 subfield placing an optrode (bipolar recording electrode attached to an optic fiber) at the injection site and a stimulation electrode targeting SCs. Effects of illumination parameters required to activate GtACR2 such as light power densities (LPDs), illumination delays, and light-pulse durations were tested on CA1 EP parameters [population spike (PS) amplitude and field excitatory postsynaptic potential (fEPSP) slope].ResultsIn the GtACR2 group, delivery of a 10 ms light-pulse induced a negative deflection in the local field potential which increased with increasing LPD. When combined with electrical stimulation of the SCs, light-induced activation of GtACR2 had potent inhibitory effects on CA1 EPs. An LPD of 160 mW/mm2 was sufficient to obtain maximal inhibition CA1 EPs. To quantify the duration of the inhibitory effect, a 10 ms light-pulse of 160 mW/mm2 was delivered at increasing delays before the CA1 EPs. Inhibition of EPs was found to last up to 9 ms after the cessation of the light-pulse. Increasing light-pulse durations beyond 10 ms did not result in larger inhibitory effects.ConclusionPrecisely timed activation of GtACR2 potently blocks evoked activity of CA1 neurons. The strength of inhibition depends on LPD, lasts up to 9 ms after a light-pulse of 10 ms, and is independent of the duration of the light-pulse given.
Employment of Artificial Intelligence Based on Routine Laboratory Results for the Early Diagnosis of Multiple Myeloma
Authors: Yan Wei , Shi Hua , He Tao , Chen Jian , Wang Chen , Liao Aijun , Yang Wei , Wang Huihan 
Published: March 2021

ObjectiveIn order to enhance the detection rate of multiple myeloma and execute an early and more precise disease management, an artificial intelligence assistant diagnosis system is developed.Methods4,187 routine blood and biochemical examination records were collected from Shengjing Hospital affiliated to China Medical University from January 2010 to January 2020, which include 1,741 records of multiple myeloma (MM) and 2,446 records of non-myeloma (infectious diseases, rheumatic immune system diseases, hepatic diseases and renal diseases). The data set was split into training and test subsets with the ratio of 4:1 while connecting hemoglobin, serum creatinine, serum calcium, immunoglobulin (A, G and M), albumin, total protein, and the ratio of albumin to globulin data. An early assistant diagnostic model of MM was established by Gradient Boosting Decision Tree (GBDT), Support Vector Machine (SVM), Deep Neural Networks (DNN), and Random Forest (RF). Out team calculated the precision and recall of the system. The performance of the diagnostic model was evaluated by using the receiver operating characteristic (ROC) curve.ResultsBy designing the features properly, the typical machine learning algorithms SVM, DNN, RF and GBDT all performed well. GBDT had the highest precision (92.9%), recall (90.0%) and F1 score (0.915) for the myeloma group. The maximized area under the ROC (AUROC) was calculated, and the results of GBDT (AUC: 0.975; 95% confidence interval (CI): 0.963–0.986) outperformed that of SVM, DNN and RF.ConclusionThe model established by artificial intelligence derived from routine laboratory results can accurately diagnose MM, which can boost the rate of early diagnosis.