bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stunting and Wasting Among Children 0-59 Months of Age in Zambézia and Nampula Provinces of Mozambique: An Assessment of Population-Based Survey Results Against Global Targets
Authors: Green Ann F. , Wilson Carole J. , Gonzalez-Calvo Lazaro , Pierce Leslie , Quelhas Diana , Rodriguez Javier , Amaro Marla , Tomo Simão , Moon Troy D. 
Published: August 2021

Abstract
Background: The number of undernourished children worldwide has increased by 45 million since 1990. In Mozambique, Zambézia and Nampula Provinces carry a heavy burden of infectious diseases, as well as high rates of stunting and wasting. Mozambique developed a Multisectoral Action Plan for the Reduction of Stunting (2011–2014) that aimed to reduce the national prevalence of stunting to 20% by 2020, but little is documented of its impact on childhood stunting since the 2011 DHS survey.Methods: Cross-sectional data from a population-based household-level survey was collected between February and July 2019, among heads of households ≥ 15 years of age in Zambézia and Nampula Provinces. The survey tool was a 500-item questionnaire covering domains related to household health and economics, with a special emphasis on maternal and child health, nutrition and WASH and the collection of anthropometric measurements in children 0-59 months. Children were assessed for Stunting and Wasting according to the WHO Child Growth Standards. SurveyToGo software was used for developing the data collection form, gathering data on mobile devices and sending securely to a server. Descriptive statistics were calculated for continuous variables as median with interquartile range and for categorical variables as percentages. The significance level for all testing was two-sided, set at 0.05.Results: A total of 3,937 households were included in our analysis, including anthropometric measurements of 5,423 children under five. Nearly half (45%, n=2,460) of all children assessed met the criteria for stunting, with a higher prevalence in Nampula Province (51%, n=1,180) than Zambézia Province (41%, n=1,280). Four percent of children met the criteria for wasting in both provinces with children aged 6-11-months having the highest wasting prevalence overall (7%).Conclusions: Based on survey results using highly standardized anthropometric measurement methods, these two provinces are on track to meet international 2025 targets for reduction in wasting in children under 5 years. However, stunting prevalence over time in both provinces has maintained at 40-50% with no clear evidence of decline since 2003. It is doubtful the related Sustainable Development Goal targets will be reached unless a focused multi-sectoral approach is employed and closely monitored.
The Effect of The Oil Consumption Pattern on Atherogenic Index of Plasma: Evidence From a Cohort Study in West of Iran
Authors: Moradinazar Mehdi , Sahargahi Badrieh , Najafi Farid , Darbandi Mitra , Moludi Jalal , Hamzeh Behrooz , Pasdar Yahya , Shokouhizadeh Rozhan , Shakiba Ebrahim 
Published: August 2021

Abstract
Background

The amount and type of lipids consumed greatly impact serum lipid profile and risk of cardiovascular diseases (CVDs). A novel index named atherogenic index of plasma (AIP) is a better predictor of CVD risk factors than lipids alone. This study aimed to investigate the effect of edible oils on AIP.
Methods

This cross-sectional study was conducted on the preliminary phase of Ravansar Non-Communicable Disease (RaNCD) cohort study. The amount of consumption of edible lipids was determined based on the validated Food Frequency Questionnaire (FFQ). AIP was calculated as log10 (TG/HDL-C).
Results

From 9996 participantes, 4738(47.4%), were male. The mean of AIP was 0.98 ± 0.6 (range from − 1.73 to 4.15), which in females (0.97 ± 0.6) was lower than males (1.10 ± 0.6). After controlling for confounding and affecting variables, the AIP index decreased with increasing consumption of a local oil named Kermanshahi oil [β(CI 95% ): -0.006(-0.008, -0.003)], butter[β(CI 95% ): -0.008(-0.011, -0.005)] and not statistically significant decrease with Hydrogenated or partial hydrogenated oil [β(CI 95% ): -0.008(-0.001, 0.001)] but the AIP index increased with un-hydrogenated oil [β(CI 95% ): 0.001(-0.001, 0.001)]
Conclusions

Kermanshahi oil and butter have a decreasing effect on AIP, the effect of margarine was neutral, and hydrogenated vegetable oil has a decreasing effect, whereas un-hydrogenated vegetable oil has an increasing effect on it. So, consumption of Kermanshahi oil may be associated with lower cardiovascular risk.
The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
Authors: Barazandeh Marjan , Kriti Divya , Nislow Corey , Giaever Guri 
Published: August 2021

Abstract
BackgroundChemogenomic profiling is a powerful approach towards understanding the genome-wide cellular response to small molecules. Developed in Saccharomyces cerevisiae, chemogenomic screens provide direct, unbiased identification of drug target candidates as well as genes required for drug resistance. While many laboratories have performed chemogenomic fitness assays, they have not been assessed for reproducibility and accuracy. Here we analyze the two largest independent yeast chemogenomic datasets comprising over 35 million gene-drug interactions and more than 6000 unique chemogenomic profiles; the first from our own academic laboratory and the second from the Novartis Institute of Biomedical Research (NIBR).ResultsCombining the datasets revealed robust genetic interaction response signatures that point to common mechanism of action, despite the substantial differences in experimental and analytical pipelines. We previously reported that the cellular response to small molecules is limited and can be described by a network of 45 chemogenomic signatures. In the present study, we show that the majority of these signatures (66%) are also found in the companion dataset, providing further support for their biological relevance as systems-level, small molecule response systems. ConclusionsOur results demonstrate the robustness of chemogenomic fitness profiling in yeast, while offering guidelines for performing other high-dimensional comparisons including parallel CRISPR screens in mammalian cells.
The Numerical Simulation of the Generation of Lower Band VLF Chorus Using a Quasi-Broadband Vlasov Hybrid Simulation Code
Authors: Nunn David 
Published: August 2021

Abstract
In this paper we perform the numerical modelling of lower band VLF chorus in the earth’s magnetosphere. Assuming parallel propagation the 1d3v code has one spatial dimension z along the ambient magnetic field, which has a parabolic z dependence about the equator. The method used is Vlasov Hybrid Simulation (VHS) also known in the literature as the method of Kinetic Phase Point Trajectories (Nunn 1990,1993; Kazeminezhad et al. 2003). The method is straightforward and easy to program, and robust against distribution function filamentation. Importantly VHS does not invoke unphysical smoothing of the distribution function. Previous versions of the VLF/VHS code had a narrow bandwidth ~100Hz, which enabled simulation of a wide variety of discrete triggered emissions. The present quasi-broadband VHS code has a bandwidth of ~3000Hz, which is far more realistic for the simulation of chorus in its entirety. Further the quasi-broadband code does not require artificial saturation, and does not need to employ matched filtering to accommodate large spatial frequency gradients. The aim of this paper which has been achieved is to produce VLF chorus Vlasov simulations employing a systematic variety of triggering input signals, namely key down, single pulse, PLHR, and broadband hiss.
User Testing of a Scottish Intercollegiate Guideline Network Public Guideline for the Parents of Children with Autism.
Authors: Fearns Naomi , Walker Laura , Graham Karen , Gibb Norman , Service Duncan 
Published: August 2021

Abstract
Background: The Scottish Intercollegiate Guidelines Network (SIGN) is the leading national clinical guideline producer in Scotland. Improved design and dissemination of guidelines produced for the public can empower people to take an active role in self-management and shared decision-making. The aim of this study was to test a public version of a guideline with the parents of children and young people with autism, implement improvements, and identify what works in making it usable and accessible. Methods: Parents were recruited from across Scotland. User testing involved a formal ‘think aloud’ process and semi-structured interview that guided users through the booklet. Sessions took place individually and were recorded and transcribed. Key findings were identified and themed using the honeycomb user experience model.Results: Fourteen user-testing sessions were conducted. Key facilitators for usability and desirability of the guideline included the chunking of text, consistent use of colour and the use of boxes to highlight important information. Simple language, written in a tone of partnership, helped to engage parents. Value arose from the guidelines ability to explain the process of diagnosis and make parents feel empowered in their relationship with healthcare professionals. There was a lack of consensus on the usefulness of rating the strength of evidence and recommendations. Conclusion: There was a marked similarity between what was important to the parents and what is important for other groups. The involvement of patients and carers in the guidelines development was key to its credibility. One size does not fit all in presenting evidence-based recommendations to the public and it is a challenge to provide sufficient information while avoiding information overload. Recommendations and evidence levels are suitable for use in public versions, but these should be kept as simple as possible.
Mapping Research Trends of Uveal Melanoma: A Bibliometric Analysis
Authors: Li Senmao , Guo Yongwei , Hou Xiaoyi , Liu Jinhua , Fan Wanlin , Ju Sitong , Matos Philomena A. Wawer , Rokohl Alexander C. , Heindl Ludwig M. 
Published: August 2021

Abstract
Background: To explore the research trends for uveal melanoma (UM) with bibliometric methods using Web of Science Core Collection (WoSCC) and PubMed (PM).Methods: To find UM-related studies, “uveal melanoma” was used as search term in the WoSCC and PM for the period time from 2000 to 2020. Bibliographic coupling analysis was used to investigate the journals with the highest number of UM-related publications. VOSviewer (VV) was used for mapping the knowledge domain and visualizing the co-occurrence of terms, authors, organizations, countries, co-citation literature, and keywords. The knowledge map based on WoSCC and PM were compared.Results: In the WoSCC 3,748 articles were found, while in PM the search resulted in 3,403 articles. The number of original articles has steadily grown in general in the past two decades. The top ten authors were contributing to 23% (n= 856) of all publications, while the top 10 institutions published 41% (n= 1524) of all articles. The top 3 journals with the highest number of publications for UM-related research included Investigative ophthalmology & visual science, Ophthalmology, and British Journal of Ophthalmology. Co-occurrence analysis based on author keywords showed 6 clusters. The most frequent keywords included metastasis, prognosis, and brachytherapy. The latest research hotspots focused on BAP1, immunotherapy and GNAQ.Conclusions: Genetics and immunology are the latest research frontiers in uveal melanoma. There is a clear need for interdisciplinary, molecular and clinical research approaches to improve the fatal prognosis of uveal melanoma patients.
Theoretical Calculations of Structural, Mechanical, Electronic And Optical Properties of Sn2S3 Under Pressure
Authors: Chen Baishu , Zhu Wenxia , Wang Chunxiang , Wang Chang , Li Yuanzuo , Liu Weilong 
Published: August 2021

Abstract
The pressure effect on the structural, mechanical, electronic and optical properties of Sn2S3 in the pressure range of 0–35 GPa have been evaluated by means of the first-principles calculations based on the density-functional theory. The structural parameters of Sn2S3 at 0 GPa such as lattice constants and cell volumes are consistent with the previous theoretical and experiment reports. The mechanical properties about the elastic constants (Cij) and polycrystalline elastic modulus (B, G and E) under pressure are calculated for the first time. Furthermore, the results suggest that the Sn2S3 is predicted to be mechanically stable in the range of pressure from 0 to 35 GPa in the light of the mechanical stability conditions. The Sn2S3 is found to be ductile from the value of B/G. With the increasing of pressure, the ductility of Sn2S3 enhances monotonously. The pressure effect on the energy band gap and density of states of Sn2S3 is also discussed, which indicates that the pressure makes the band gap of Sn2S3 decreased. The optical properties of Sn2S3 are calculated in the range 0–35 eV, and the results show that the Sn2S3 under pressure has stronger visible light absorption in comparison with 0 GPa.
HIF-1α overexpression in adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia-induced dysfunction and inflammation in HUVECs
Authors: Chen Xingxing , Sun Yonghong , Lei Xiaoyan , Cao Yunshan , Gao Mingdong , Chen Junhui , Bao Baixin , Chen Lili 
Published: August 2021

Abstract
Background
Increasing evidence suggests that ADSCs execute their paracrine function via the secretion of exosomes, especially under hypoxic conditions. However, the mechanisms by which ADSCs-derived exosomes (ADSC-exos) enhance angiogenesis under hypoxia remain unclear.
Methods
Exosomes were isolated from HIF-1α-modified ADSCs culture supernatants. To investigate the effects HIF-1α-ADSC-exos on HUVECs, cell growth, apoptosis, and tube formation assay were performed with or without HIF-1α-ADSC-exos. Moreover, to determine the function of HIF-1α-ADSC-exos, the therapeutic effects of ADSC-exos and HIF-1α-ADSC-exos were examined in PAH rats.
Results
Exosomes released by HIF-1α-modified ADSCs rescued the impaired angiogenic ability, migratory function, and inflammatory factors of hypoxia-injured HUVECs, with increased SDF-1α, Rac1, Rac2, VEGF and IL-10 expression. Furthermore, exos-HIF-1α activated SIRT3 to enhance angiogenesis in HUVECs and induced IL-10 expression to inhibit inflammatory response. Block SIRT3 or SDF-1α abolished the angiogenic effect in HUVECs.
Conclusion
Our findings indicated that the SIRT3 contributed a crucial role in HIF-1α-ADSC-exos in tissue repair under hypoxia.
Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study
Authors: Jablonski Kim Philipp , Carron Leopold , Mozziconacci Julien , Forné Thierry , Hütt Marc-Thorsten , Lesne Annick 
Published: August 2021

Abstract
Background
Genome-wide association studies have identified statistical associations between various diseases, including cancers, and a large number of single-nucleotide polymorphisms (SNPs). However, they provide no direct explanation of the mechanisms underlying the association. Based on the recent discovery that changes in 3-dimensional genome organization may have functional consequences on gene regulation favoring diseases, we investigated systematically the genome-wide distribution of disease-associated SNPs with respect to a specific feature of 3D genome organization: topologically-associating domains (TADs) and their borders.
Results
For each of 449 diseases, we tested whether the associated SNPs are present in TAD borders more often than observed by chance, where chance (i.e. the null model in statistical terms) corresponds to the same number of pointwise loci drawn at random either in the entire genome, or in the entire set of disease-associated SNPs listed in the GWAS catalog. Our analysis shows that a fraction of diseases displays such a preferential localization of their risk loci. Moreover, cancers are relatively more frequent among these diseases, and this predominance is generally enhanced when considering only intergenic SNPs. The structure of SNP-based diseasome networks confirms that localization of risk loci in TAD borders differ between cancers and non-cancer diseases. Furthermore, different TAD border enrichments are observed in embryonic stem cells and differentiated cells, consistent with changes in topological domains along embryogenesis and delineating their contribution to disease risk.
Conclusions
Our results suggest that, for certain diseases, part of the genetic risk lies in a local genetic variation affecting the genome partitioning in topologically-insulated domains. Investigating this possible contribution to genetic risk is particularly relevant in cancers. This study thus opens a way of interpreting genome-wide association studies, by distinguishing two types of disease-associated SNPs: one with a direct effect on an individual gene, the other acting in interplay with 3D genome organization.
Comparison and predesign cost assessment of ozonation, membrane filtration and activated carbon for the treatment of recalcitrant organics, a conceptual study
Authors: Peyrelasse Christine , Jacob Matthieu , Lallement Audrey 
Published: August 2021

Abstract
The presence of micropollutants in the environment is today of major concern. These pollutants could have long-term impacts on the environment and on population health. Biological treatment of wastewater is generally insufficient to allow their complete elimination. The establishment of efficient treatments is then needed to degrade the refractory organic matter. Activated carbon adsorption, membrane filtration and oxidation processes are common suitable solutions. All of them have advantages and are effective to treat wastewaters but drawbacks are well known such as waste production, energy consumption or by-products formation. This study aims at defining a strategy to choose the best option according to the nature of the wastewater and the treatment objectives. A methodology was designed for the rating of theses processes to choose the best strategy regarding environmental, technical and economic criteria. A simulation of three wastewater treatment scenarios was carried out to compare the costs of ozonation, adsorption and reverse osmosis. According to the result obtained, a decision tree is proposed to define the best option for a tertiary treatment to reach reuse or discharge objectives.
Limit Cycle Oscillation Suppression Controller Design and Stability Analysis of the Periodically Time-varying Flapping Flight Dynamics in Hover
Authors: Wang Liang , Jiang Wuyao , Jiao Zongxia , Zhao Longfei 
Published: August 2021

Abstract
The periodically time-varying forces make the equilibrium state of Beihawk, an X-shaped flapping-wing aircraft, to be a periodic limit cycle oscillation. However, traditional controllers based on averaging theory fail to suppress this oscillation and the derived stability result may be inaccurate. In this study, a period-based method is proposed to design the oscillation suppression controller, locate the corresponding cycle and analyze its stability. A periodically time-varying wing–tail interaction model is built and Discrete Fourier Transform is applied to adapt the model for controller design. The harmonics less than quintuple flapping frequency account for more than 96 percent of the total harmonics and are reserved to present a concise model. Based on this model, Active Disturbance Rejection Controller (ADRC) is designed and its Extended State Observer can observe the disturbance to suppress the oscillation. Poincaré map is introduced to convert the stability analysis of the cycle to a fixed point. A multiple shooting method is adopted to locate several points on the cycle and the map is obtained by calculating the submaps between the adjacent points with the Floquet theory. The located points are proved to be accurate compared with the numerical solved cycle and the stability analysis result of the cycle is verified by the dynamic evolution. Compared with the State Feedback Controller, the ADRC performs better in suppressing the limit cycle oscillation and eliminating the attitude control error. The oscillation suppression is meaningful in maintaining a stable flight and capturing high quality images.
Developing effective subsoil reference model for seismic microzonation studies.
Authors: Pieruccini Pierluigi , Paolucci Enrico , Fantozzi Pier Lorenzo , Naldini Duccio Monaci , Albarello Dario 
Published: August 2021

Abstract
A general methodological approach is here discussed to integrate geological and geophysical information in seismic microzonation studies. In particular, the methodology aims at maximizing the exploitation of low-cost data for extensive preliminary assessment of ground motion amplification phenomena induced by the local seismostratigraphical configuration. Three main steps are delineated: a) the combination of geological/geomorphological analyses to develop an Engineering-Geological Model of the study area; b) targeted geophysical prospecting to provide an Engineering-Geological/Geophysical Model; c) evaluating effectiveness of Engineering-Geological/Geophysical Model by estimating expected ground motion amplification phenomena by the use of suitable computational tools. The workflow is illustrated by a case-study based on a set of villages in the Umbro-Marchean Apennine (Central Italy) damaged during the Seismic sequence occurred in Central Italy during 2016–2017.
Dual Operated Firefighting Robot
Authors: Sugathan Akash , Balakrishnan Manoj , Pillai Abhijith A. , R Arjun , Varghese Athul P. 
Published: August 2021

Abstract
In this study, a dual operated firefighting robot was designed, fabricated and analyzed. The robot can be operated in both RC and automatic modes. The robot consists of three different types of system units- fire detection system, extinguishing system and communication system. The fire detection system uses flame sensors for detection of fire. The extinguishing unit consists of fire extinguisher cylinder mounted on the robot which can be controlled by the user through a remote. . The fire extinguisher is operated with the help of a relay circuit. The whole set up is controlled and monitored by the main controller or microprocessor. Using a belt drive enables the robot to climb stairs. The main chassis consists of 400mm*390mm aluminum profile. Four motors, each of 60 rpm, are used which provides adequate thrust for motion. The power supply for the functioning of robot is provided by a 12V, 7 AH battery. The compact design of the firefighting robot enables it to enter small or narrow space with ease. More over the dual operation ability of the robot helps to increase the overall efficiency of the robot.