bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a Physical Therapy Intervention to Improve the Quality of Life of Visually Impaired People: Development of an Audio–Tactile Exercise Protocol
Authors: Borges Silva Maristella , Novais Shimano Suraya Gomes , Lopes de Oliveira Nuno Miguel 
Published: June 2021

Introduction: The purpose of this study was to develop and implement an audio–tactile protocol for therapeutic intervention in individuals with visual impairments. Methods: The Physiotherapy Protocol for People with Visual Impairment (PP-PVI) was developed following five steps: physiotherapy evaluation, linguistic selection, protocol design, linguistic adequation for visually impaired, and linguistic adequation for English language. Three adolescents and three young adults with visual impairments participated in this longitudinal study and performed the protocol of therapeutic exercises twice a week for 12 months while being evaluated with respect to their quality of life before and after. The quality of life was evaluated using the 36-item Short Form Health Survey (SF-36). Results: The median score for all domains of the quality of life questionnaire improved after PP-PVI, with the exception of the body pain domain, which remained unchanged. Discussion: The PP-PVI was shown to be an important method of therapeutic intervention, and it was easy to understand and apply in persons with visual impairments. Implications for practitioners: The exercises of the PP-PVI facilitate the development of several physical and functional capabilities that are important to the independence of individuals with visual impairments.
Dietary acculturation of international students in Pune, India: a cross-sectional study
Authors: Mahmoodi Mahnaaz , George Roopan Miriam , Gokhale Devaki 
Published: June 2021

Background: Dietary acculturation refers to how a migrant group adopts the eating patterns of the host country. It results in changes in dietary behavior, dietary intake, and nutritional status of this vulnerable group. Aim: To study dietary acculturation of international students in Pune, India. Methods: International students from three Universities in Pune were enrolled. Information on demography, dietary behavior, and dietary intake (using a food frequency questionnaire) was recorded using an interviewer-administered questionnaire. The height and weight of the students were measured using standard, calibrated equipment. The data were analyzed using descriptive and analytical statistics. Results: A total of 100 international students from Iran, Africa, and South Korea were grouped by nationality. Considerable variation was detected in the daily number of meals consumed, skipping meals, portion size changes, packaged food consumption, and supplement intake following migration between the groups. The intake of non-vegetarian food had declined drastically for all groups. However, the specific non-vegetarian item showing the greatest change differed according to the group’s nationality. The intake of biscuits and cake had increased among all groups. African students showed an increase of 3.33 kg in body weight following migration. The intake of protein and micronutrients declined for all groups. Conclusions: This study highlights the changes in dietary behavior, dietary intake, and nutritional status of international students of different nationalities following migration to Pune, India. Thus, it emphasizes the need for nutrition interventions in international students in India.
Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals
Authors: McCulloch Drummond E-Wen , Madsen Martin Korsbak , Stenbæk Dea Siggaard , Kristiansen Sara , Ozenne Brice , Jensen Peter Steen , Knudsen Gitte Moos , Fisher Patrick MacDonald 
Published: June 2021

Background: Psilocybin is a psychedelic drug that has shown lasting positive effects on clinical symptoms and self-reported well-being following a single dose. There has been little research into the long-term effects of psilocybin on brain connectivity in humans. Aim: Evaluate changes in resting-state functional connectivity (RSFC) at 1 week and 3 months after one psilocybin dose in 10 healthy psychedelic-naïve volunteers and explore associations between change in RSFC and related measures. Methods: Participants received 0.2–0.3 mg/kg psilocybin in a controlled setting. Participants completed resting-state functional magnetic resonance imaging (fMRI) scans at baseline, 1-week and 3-month post-administration and [11C]Cimbi-36 PET scans at baseline and 1 week. We examined changes in within-network, between-network and region-to-region RSFC. We explored associations between changes in RSFC and psilocybin-induced phenomenology as well as changes in psychological measures and neocortex serotonin 2A receptor binding. Results: Psilocybin was well tolerated and produced positive changes in well-being. At 1 week only, executive control network (ECN) RSFC was significantly decreased (Cohen’s d = −1.73, pFWE = 0.010). We observed no other significant changes in RSFC at 1 week or 3 months, nor changes in region-to-region RSFC. Exploratory analyses indicated that decreased ECN RSFC at 1 week predicted increased mindfulness at 3 months ( r = −0.65). Conclusions: These findings in a small cohort indicate that psilocybin affects ECN function within the psychedelic ‘afterglow’ period. Our findings implicate ECN modulation as mediating psilocybin-induced, long-lasting increases in mindfulness. Although our findings implicate a neural pathway mediating lasting psilocybin effects, it is notable that changes in neuroimaging measures at 3 months, when personality changes are observed, remain to be identified.
Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma
Authors: Xing Ying , Sun Xianhua , Li Feng , Jiang Xuan , Jiang Afang , Li Xiaofan , Lv Ruiting , Shao Liwei 
Published: June 2021

Objective Long non-coding RNA (lncRNA) expression is closely related to the pathogenesis and progression of various tumors. In this study, we investigated the mechanisms of lncRNA HOXB cluster antisense RNA 3 (HOXB-AS3), miRNA(miR)-498-5p, and disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) in endometrial carcinoma (EC) cells. Methods The expression levels of lncRNA HOXB-AS3 in EC tissues and cells were detected using RT-qPCR assays. The effects of HOXB-AS3 knockdown on EC cell proliferation and apoptosis were measured using CCK-8 assays, colony formation assays, and flow cytometry. In addition, putative miR-498-5p binding sites were identified in HOXB-AS3 and ADAM9. The targeted relationships were further verified using dual-luciferase reporter and RNA pull-down assays. Results HOXB-AS3 expression was upregulated in EC tissues and cells. EC cell proliferation and viability decreased significantly in HOXB-AS3 knockdown groups. A putative miR-498-5p binding site in HOXB-AS3 was verified. Inhibition of miR-498-5p rescued the effects of HOXB-AS3 knockdown on cell proliferation and apoptosis. Finally, ADAM9 was verified as a direct target gene of miR-498-5p. Conclusions Our results suggest that lncRNA HOXB-AS3 is highly expressed in EC tissues and cells. Downregulation of HOXB-AS3 inhibits cell proliferation and promotes apoptosis in EC cells. HOXB-AS3 can upregulate ADAM9 expression by sponging miR-498-5p.
Invasive lobular carcinoma: clinicopathological features and subtypes
Authors: Danzinger Sabine , Hielscher Nora , Izsó Miriam , Metzler Johanna , Trinkl Carmen , Pfeifer Christian , Tendl-Schulz Kristina , Singer Christian F. 
Published: June 2021

Objective To analyze the characteristics of invasive lobular carcinoma (ILC) compared with invasive ductal carcinoma (IDC) and to investigate the impact of histology on axillary lymph node (ALN) involvement in luminal A subtype tumors. Methods We retrospectively analyzed patients diagnosed with ILC or IDC from 2012 to 2016 who underwent surgery. Patients constituted 493 primary early breast cancer cases (82 ILC; 411 IDC). Results Compared with IDC, ILC tumors were significantly more likely to be grade 2, estrogen receptor- (ER) positive (+), have a lower proliferation rate (Ki67 <14%), and a higher pathological T stage (pT2–4). The luminal A subtype was significantly more common in ILC compared with IDC. In a multivariate regression model, grade 2, ER+, progesterone receptor-positive, pT2, and pT3 were significantly associated with ILC. Additionally, with the luminal A subtype, ALN involvement (pathological node stage (pN)1–3) was significantly more frequent with ILC versus IDC. Conclusions Our data suggest that grade 2, positive hormone receptor status, and higher pathological T stage are associated with ILC. With the luminal A subtype, ALN involvement was more frequent with ILC versus IDC.
Bioinformatics analysis of key biomarkers for retinoblastoma
Authors: Zhao Xin-mei , Li Yuan-Bin , Sun Peng , Pu Ya-di , shan Meng-jie , Zhang Yuan-meng 
Published: June 2021

Objective To identify key genes involved in occurrence and development of retinoblastoma. Methods The microarray dataset, GSE5222, was downloaded from the gene expression omnibus (GEO) database. Differentially expressed genes (DEGs) between unilateral and bilateral retinoblastoma were identified and functional enrichment analysis performed. The protein–protein interaction (PPI) network was constructed and analysed by STRING and Cytoscape. Results DEGs were mainly associated with activation of cysteine-type endopeptidase activity involved in apoptotic process and small molecule catabolic process. Seven genes (WAS, GNB3, PTGER1, TACR1, GPR143, NPFF and CDKN2A) were identified as HUB genes. Conclusion Our research provides more understanding of the mechanisms of the disease at a molecular level and may help in the identification of novel biomarkers for retinoblastoma.
Prognostic significance of CEA, Ki67 and p53 in pseudomyxoma peritonei of appendiceal origin
Authors: Yan Fengcai , Shi Feng , Li Xinbao , Chang Hong , Jin Mulan , Li Yan 
Published: June 2021

Objective To determine the levels of carcinoembryonic antigen (CEA), proliferating nuclear antigen Ki67 and p53 in pseudomyxoma peritonei (PMP) of appendiceal origin and to correlate the levels with clinicopathological characteristics and overall survival. Methods This retrospective study collected data on clinicopathological features and immunohistochemical staining of CEA, Ki67 and p53 in patients with PMP of appendiceal origin. Overall survival was evaluated using Kaplan–Meier plots. Median survival time was estimated by Log-rank tests. Potential prognostic factors were evaluated by Cox proportional hazards regression models. Results A total of 141 patients with PMP of appendiceal origin were enrolled in the study with a median age of 54 years. Of these, 93 (66.0%) were diagnosed with low-grade mucinous carcinoma, 43 (30.5%) with high-grade mucinous carcinoma and five (3.5%) with high-grade with signet ring cells. CEA exhibited ubiquitous immunopositivity in most cases and was not associated with overall survival. Ki67 labelling index (LI) and p53 status were related to histological grade and overall survival. The main pathological indicators affecting survival included histological grade, lymph node involvement, angiolymphatic invasion, Ki67 LI and p53. Conclusion Combined analysis of high Ki67 LI and aberrant p53 may provide the basis for evaluating the biological behaviour of PMP and predicting clinical outcome.
Identifying research priorities for occupational therapy in the UK: A James Lind Alliance Priority Setting Partnership
Authors: Watson Jo , Cowan Katherine , Spring Hannah , Donnell Jenny Mac , Unstead-Joss Ruth 
Published: June 2021

Introduction As the scope and nature of practice evolves in an ever-changing health and social care landscape, it is imperative the profession continues to expand the evidence base underpinning interventions. The Royal College of Occupational Therapists partnered with the James Lind Alliance to bring together people with lived experience, occupational therapists and other people working in the health and care sector to identify contemporary research priorities for the profession in the United Kingdom. Method The JLA’s well-established methodology was adopted. An opening consultation survey gathered unanswered questions. Analysis of responses and evidence checking preceded an initial prioritisation survey. The final prioritisation workshop drew on nominal group technique. Findings 927 respondents submitted 2193 questions. Those within the project’s scope were captured in 66 overarching summary questions using thematic analysis. These were initially ranked by 1140 respondents. 18 questions comprising the 10 most highly ranked by people with lived experience and by those with professional experience were considered by 19 participants in the final workshop. Together, they reached consensus on the Top 10 priorities. Conclusion These research priorities provide a contemporary framework influencing and guiding future research, ensuring it addresses the issues of greatest importance to people accessing and delivering services.
Interactions among Infrastructure, Trade Openness, Foreign Direct Investments and Economic Growth in India
Authors: Sarania Rahul 
Published: June 2021

This study examines the dynamic interrelationships among infrastructure, trade openness, foreign direct investments (FDI), economic growth, fixed capital formation, labour and inflation rate in the context of India for the period 1970 to 2018 through the application of Toda–Yamamoto (TY) causality test and the auto-regressive distributed lag (ARDL) bounds testing approach to cointegration to offer policy implications of the effectiveness of these important macroeconomic determinants in the short and long-run. This article developed two composite indices, namely, infrastructure development index (INFI) and trade openness index (TOI) and used to see the effectiveness of infrastructure indicators and trade openness on economic growth along with other variables of interest. Results suggest a strong causal short and long run interrelationship among infrastructure, FDIs, trade openness and economic growth during 1970–2018. In the long run, a bi-directional relationship exists between INFI and GDP, suggesting that India should expedite construction of adequate and expanded infrastructure facilities in the economy and among others things, frame its policy in a more liberalised manner for various sectors including infrastructure with a view to attracting more FDI inflows and making more openness to trade and globalisation within the environment of ease of doing business that would help to sustain higher economic growth for long period, accomplishing the goal of US$5 trillion economy by 2024–25. JEL Classification:H54, O1, H4, O4, P33, L9, C32
Infrastructure for Structural Transformation: A Comebackof Planning?
Authors: Gottschalk Ricardo , Sampath Padmashree Gehl 
Published: June 2021

This article examines how infrastructure development may best support structural transformation in developing countries. It critiques ongoing emphasis by multilateral financial institutions and other actors on infrastructure as an asset class and their focus on bankable projects. The article considers this approach too narrow for real economic transformation and argues development requires a more holistic approach, one that includes project assessment based on developmental criteria. Drawing on the pioneers of development and more recent literature on infrastructure systems, the article proposes development planning as a more promising approach and assesses how developing countries are faring regarding infrastructure planning for growth and transformation. JEL Classification: H54, O21, O40, P11
Association of Visual Appearance on Outcomes After Hallux Valgus Surgery
Authors: Bahar Hakan , Yildiz Kadir Ilker 
Published: June 2021

Background: In this study, our aim was to determine the effect of cosmetic improvement on patient satisfaction and functional scores in hallux valgus (HV) surgery. Methods: Preoperative foot photographs of 105 patients who had undergone chevron osteotomy for HV between 2016 and 2018 were taken. The patients were divided into 2 groups. Twenty-four months after surgery, the preoperative foot photographs were shown to patients in group 1 (n = 52) but not to patients in group 2 (n = 53). The groups were then compared using the visual analog scale (VAS), the American Orthopaedic Foot & Ankle Society Hallux Metatarsophalangeal-Interphalangeal (AOFAS Hallux MTP-IP), and the 36-Item Short Form Health Survey (SF-36) scores. Both groups were evaluated radiologically with preoperative and postoperative hallux valgus angles and intermetatarsal angles. Results: There was no difference between the 2 groups in terms of radiologic parameters either pre- or postoperatively, or AOFAS Hallux MTP-IP scores postoperatively. However, for group 1, the VAS was lower (0.4±0.8 vs 1.8±1.6, P = .003) and both the SF-36 physical functioning (88.3±18.1 vs 79.1±23.2, P = .017) and SF-36 mental health scores were higher (78.8±19 vs 69.2±16.3, P = .022). Conclusion: Visualizing improvement in the cosmetic appearance of the foot appears associated with patients’ perception of subjective pain and functional improvement. We recommend that preoperative foot photographs be taken and recorded. Level of Evidence: Level III, case-control study.
The Hallux Metatarsophalangeal Capsule: An Anatomic Study With Respect to Percutaneous Hallux Valgus Correction
Authors: Chin Kenneth M. , Richardson Nicholas S. , Campbell John T. , Jeng Clifford L. , Christian Matthew W. , Cerrato Rebecca A. 
Published: June 2021

Background: Minimally invasive surgery for the treatment of hallux valgus deformities has become increasingly popular. Knowledge of the location of the hallux metatarsophalangeal (MTP) proximal capsular origin on the metatarsal neck is essential for surgeons in planning and executing extracapsular corrective osteotomies. A cadaveric study was undertaken to further study this anatomic relationship. Methods: Ten nonpaired fresh-frozen frozen cadaveric specimens were used for this study. Careful dissection was performed, and the capsular origin of the hallux MTP joint was measured from the central portion of the metatarsal head in the medial, lateral, dorsal, plantarmedial, and plantarlateral dimensions. Results: The ten specimens had a mean age of 77 years, with 5 female and 5 male. The mean distances from the central hallux metatarsal head to the MTP capsular origin were 15.2 mm dorsally, 8.4 mm medially, 9.6 mm laterally, 19.3 mm plantarmedially, and 21.0 mm plantarlaterally. Conclusion: The MTP capsular origin at the hallux metatarsal varies at different anatomic positions. Knowledge of this capsular anatomy is critical for orthopaedic surgeons when planning and performing minimally invasive distal metatarsal osteotomies for the correction of hallux valgus. Type of Study: Cadaveric Study.
Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
Authors: Chan Wing-Lok , Choi Horace Cheuk-Wai , Lang Brian , Wong Kai-Pun , Yuen Kwok-Keung , Lam Ka-On , Lee Victor Ho-Fun , Kwong Dora 
Published: June 2021

Background: Health-related quality of life (HRQoL) is important for differentiated thyroid cancer survivors, but data for Asian survivors is lacking. This study aimed to have an overview of, and identify any disease-or treatment-related factors associated with, HRQoL in Asian differentiated thyroid cancer survivors. Patients and Methods: Thyroid cancer survivors were recruited from the thyroid clinics at Queen Mary Hospital, Hong Kong from February 2016 to December 2016. All adult differentiated thyroid cancer patients with stable disease more than or equal to 1 year received a survey on HRQoL using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Thyroid cancer specific quality of life (THYCA-QoL) questionnaire. Clinical information was collected retrospectively from the computerized clinical management system. To identify factors associated with poor HRQoL, univariable and stepwise multivariable regression analysis were performed. Results: A total of 613 survivors completed the questionnaires (response rate: 82.1%; female: 80.1%; median survivorship: 7.4 years (range: 1.0-48.2 years)). The QLQ-C30 summary score mean was 84.4 (standard deviation (SD): 12.7) while the THYCA-QoL summary score mean was 39.9 (SD: 9.7). The 2 highest symptom subscales were fatigue (mean: 26.4, SD: 20.6) and insomnia (mean: 26.2, SD: 27.6). Factors associated with worse HRQoL included serum thyrotropin (TSH) greater than 1.0 mIU/L, unemployment, and concomitant psychiatric disorders. Concomitant psychiatric illness (n = 40/613, 6.5%) also showed significant association with most of the symptom and functional subscales. Conclusions: Fatigue and insomnia were the 2 most common symptoms experienced by our differentiated thyroid cancer survivors. Long-term survivorship care with monitoring serum TSH level, supporting return-to-work and screening for concomitant psychiatric disorders should be offered.
Mindfulness Training for Children with ADHD and Their Parents: A Randomized Control Trial
Authors: Valero Mónica , Cebolla Ausias , Colomer Carla 
Published: June 2021

Objective: The aim of this randomized control trial is to analyze the efficacy of a Mindfulness-based program (MYmind) in improving ADHD symptoms, associated problems, executive functions, and family functioning. Method: The sample was composed of 30 children (9–14 years old) with an ADHD diagnosis and their parents. Participants were randomized into two groups, the MYmind group ( n = 15) and a wait-list group ( n = 15). Participants were assessed in three time periods: pre-, post-intervention, and at 6-month follow-up. Results: After the program, parents reported a decrease in parenting stress and improvements in parenting styles. Six months after the intervention, parents reported significant improvements in children’s inattention symptoms, executive functions, learning problems, aggression, and peer relations. Overreactivity was the only variable that showed a decrease in both the post-test and follow-up periods. Conclusion: These results suggest that the MYmind program is a promising treatment for children with ADHD and their parents.
Two Facets of Emotion Dysregulation Are Core Symptomatic Domains in Adult ADHD: Results from the SR-WRAADDS, a Broad Symptom Self-Report Questionnaire
Authors: Weibel Sébastien , Bicego Floriane , Muller Sarah , Martz Emilie , Costache Mădălina Elena , Kraemer Charlotte , Bertschy Gilles , Lopez Regis , Weiner Luisa 
Published: June 2021

Objectives: Emotional dysregulation (ED) in adult ADHD is frequent but definition and tools for its evaluation are not consensual. Our aim was to determine the core ADHD symptomatic domains via the Self-Reported Wender-Reimherr Adult Attention Deficit Disorder Scale (SR-WRAADDS) following its validation in a large clinical sample of adults with ADHD and controls. Method: Three hundred sixty-nine adult patients with ADHD and 251 healthy participants completed the SR-WRAADDS and questionnaires about ADHD, depression, and ED. We analyzed the psychometric properties of the SR-WRAADDS and a factor analysis yielded symptomatic domains. Results: The SR-WRAADDS has good reliability. The 30 symptoms were best organized in a four-factor solution: attention/disorganization, hyperactivity/restlessness, impulsivity/emotional outbursts, and emotional lability. Conclusions: The symptomatic structure of the SR-WRAADDS includes two distinct dimensions related to ED: “impulsivity/emotional outbursts” and “emotional lability.” The SR-WRAADDS is a reliable and clinically useful tool that assesses all ADHD symptom domains, including facets of ED.