bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified cosmology through Kaniadakis horizon entropy
Authors: Lymperis Andreas , Basilakos Spyros , Saridakis Emmanuel N. 
Published: November 2021

AbstractWe apply the gravity-thermodynamics conjecture, namely the first law of thermodynamics on the Universe horizon, but using the generalized Kaniadakis entropy instead of the standard Bekenstein–Hawking one. The former is a one-parameter generalization of the classical Boltzmann–Gibbs–Shannon entropy, arising from a coherent and self-consistent relativistic statistical theory. We obtain new modified cosmological scenarios, namely modified Friedmann equations, which contain new extra terms that constitute an effective dark energy sector depending on the single model Kaniadakis parameter K. We investigate the cosmological evolution, by extracting analytical expressions for the dark energy density and equation-of-state parameters and we show that the Universe exhibits the usual thermal history, with a transition redshift from deceleration to acceleration at around 0.6. Furthermore, depending on the value of K, the dark energy equation-of-state parameter deviates from $$\Lambda $$
Λ
CDM cosmology at small redshifts, while lying always in the phantom regime, and at asymptotically large times the Universe always results in a dark-energy dominated, de Sitter phase. Finally, even in the case where we do not consider an explicit cosmological constant the resulting cosmology is very interesting and in agreement with the observed behavior.
First evidence for tooth–tooth occlusion in a ctenochasmatid pterosaur from the Early Cretaceous Jehol Biota
Authors: Zhou Chang-Fu , Wang Xinyue , Wang Jiahao 
Published: November 2021

Abstract

Ctenochasmatid pterosaurs flourished and diversified in the Early Cretaceous Jehol Biota. Here, a partial mandible of
Forfexopterus
is described based on a three-dimensional reconstruction using high-resolution X-ray computed tomography (CT) data. The first nine pairs of functional teeth of the rostral dentition revealed along with their replacements. The functional teeth are evenly arranged with a tooth density of 2.2 teeth/cm. The tooth crown is distinctly reduced from its base to the tip, and framed by two weak ridges, possibly a pair of vestigial carinae. The replacement teeth are sharp and pointed, and have erupted slightly against the medial surface of the functional teeth. Surprisingly, tooth wear is observed in this specimen, the first record of tooth–tooth occlusion in ctenochasmatids. The wear facets exhibit high-angled lingual and lower-angled labial facets, implying a unique tooth–tooth occlusion in pterosaur clade. This discovery indicates that the Jehol ctenochasmatids possibly employed a more active feeding strategy than other filter-feeding pterosaurs (e.g.
Ctenochasma
,
Pterodaustro
,
Gnathosaurus
).
The Persistence of National Victimhood: Bosniak Post-War Memory Politics of the Srebrenica Mass Killings
Authors: Rawski Tomasz 
Published: November 2021

The Persistence of National Victimhood: Bosniak Post-War Memory Politics of the Srebrenica Mass KillingsThis article reveals the origins of the radicalisation of memory politics in Bosnia and Herzegovina after the year 2010. It shows that the radicalisation in the public sphere of Bosnia and Herzegovina was eventually possible due to the long-term persistence of the nationalist commemorative strategy, rooted in the dialectic mechanism of consolidating and antagonising relevant reference groups, and responsible for structuring the national memories of the last war according to an exclusivist martyrological model. Based on the example of Bosniak post-war memory politics regarding the Srebrenica mass killings, the study describes a more universal political mechanism, one characteristic also of the post-war Bosnian Serb and Bosnian Croat nationalist factions. Trwałość martyrologii narodowej. Boszniacka powojenna polityka pamięci o masowych morderstwach w SrebrenicyArtykuł odsłania źródła radykalizacji polityki pamięci w Bośni i Hercegowinie po 2010 roku. Pokazuje, że radykalizacja ta była możliwa dzięki długotrwałemu utrzymywaniu się w sferze publicznej Bośni i Hercegowiny nacjonalistycznej strategii komemoratywnej, która była odpowiedzialna za strukturyzację narodowej pamięci o ostatniej wojnie według ekskluzywistycznego modelu martyrologicznego oraz zakorzeniona w dialektycznym mechanizmie konsolidacji i antagonizowania odpowiednich grup odniesienia. Na przykładzie powojennej boszniackiej polityki pamięci dotyczącej masowych morderstw w Srebrenicy opisany został bardziej uniwersalny mechanizm polityczny, charakterystyczny także dla powojennych polityk pamięci prowadzonych przez nacjonalistyczne elity bośniackich Serbów i bośniackich Chorwatów.
A descriptive study of mental health and burnout among Nigerian medical students
Authors: Ayinde Olatunde Olayinka , Akinnuoye Eniola Racheal , Molodynski Andrew , Battrick Oliver , Gureje Oye 
Published: November 2021

Background: Increasing attention is being paid to medical students’ mental wellbeing globally due in part to their exposure to stressors inherent in medical education and the numerous reports of elevated rates of mental health conditions in this population. Aims: This study aimed to identify stressors and determine prevalence rates of psychiatric morbidity, substance use and burnout in a sample of Nigerian medical students. Methods: In a cross-sectional online survey, 505 medical students from 25 Nigerian medical schools completed a socio-demographic questionnaire, short version of the General Health Questionnaire (GHQ-12), the CAGE questionnaire and the Oldenburg Burnout Inventory (OLBI). Result: The most commonly reported sources of stress were study (75.6%), money (52.3%) and relationships (30.1%). Nine students (1.8%) had received a mental health diagnosis prior to medical school but this number had increased to 29 (5.7%) whilst in medical school, with the majority being cases of anxiety and depressive disorders. The prevalence of psychological distress was 54.5%, but <5% of affected students had received any help for their mental health conditions. Twenty five students (5%) met criteria for problematic alcohol use and 6% had used cannabis. The proportions of students who met criteria for disengagement and exhaustion domains of the OLBI were 84.6% and 77.0% respectively. Conclusion: The prevalence of psychological distress and burnout is high among medical students. Interventions for medical students’ well-being should be tailored to their needs and should target risk factors related to personal, organisational and medical school academic structure attributes.
Clinical and psychosocial profile of persons with mental illness living in non-hospital residential facilities in a district in Kerala, India: A cross-sectional survey
Authors: Ramkumar Girija Sathiaseelan , Michael Jaimon Plathottathil , Sadath Anvar 
Published: November 2021

Background: Clinical and psychosocial profiles of persons living with mental illness (PMI) in non-hospital settings in India have not been adequately studied. Aim: This study describes the profile of PMI living in non-hospital settings by focussing on variables like functioning and social networks. Method: Residents of all available residential facilities in one district area were surveyed and descriptive data was obtained. Socio occupational functioning was assessed using the Social and Occupational Functioning Scale (SOFS) and social network was measured by modified Lubben Social Network Scale-6 (LSNS-6). Results: A total of nine centres housing 491 residents (7–128) were surveyed via field visits. The mean age of the residents was 49 ± 14.0 years. Fifty per cent of them were never married, 22% were separated or widowed. Almost half of the people had psychotic disorders, while diagnosis could not be delineated in a quarter of the population. Almost half the people reached the facilities with the help of their families, while 40% were brought by police or volunteers who found them wandering. Impairment in socio-occupational functioning was only mild in 90% of residents, while 60% did not contact relatives or friends in the past 3 months. Conclusion: PMI living in non-hospital residential facilities were on average in their middle age and were deficient in marital bonds and other social support. They had reached the centres with the help of extended family or by police/volunteers who rescued them from wandering status. Nevertheless, most of them had only mild to moderate levels of impairment, and their functional capacity was good for independent living in the community with support. Hence, newer models of supported housing that provide greater community reintegration, like independent shared housing within regular neighbourhoods, can be tried. In persons with residual family ties, providing continuous community-based support may help re-establish family integration.
Cognitive workload, complications and visual outcomes of phacoemulsification cataract surgery: Three-dimensional versus conventional microscope
Authors: Kelkar Aditya , Kelkar Jai , Chougule Yogesh , Bolisetty Mounika , Singhvi Priyanka 
Published: November 2021

Purpose To compare the surgical workload, complications, and visual outcomes using the three-dimensional visualization system with the conventional microscope in phacoemulsification cataract surgery. Design Prospective, non-randomized, open-label interventional study. Methods All patients underwent phacoemulsification cataract surgery using the three-dimensional visualization system or conventional microscope. Results Of the 203 eyes, 80 underwent surgery with the three-dimensional system while 123 underwent with the conventional microscope. No difference was noted in the total surgical duration, complication rates, and visual outcomes between the two groups. However, capsulorhexis was significantly faster using the conventional microscope while posterior chamber intraocular lens insertion was quicker using the three-dimensional system. In terms of cognitive workload comparison, no difference was seen in the surgeons’ heart rate, oxygen saturation levels, and surgery task load index total workload score and workload score for all six dimensions of the questionnaire, between the three-dimensional system and conventional microscope groups. As compared to baseline, the heart rate increased significantly during all surgical steps and at the end in both groups. When compared to baseline, the oxygen saturation levels were significantly raised during capsulorhexis, irrigation, and aspiration and posterior chamber intraocular lens insertion and at the end of the surgery in the three-dimensional group and during incision and at the end of the surgery in the conventional microscope group. Conclusions The duration of surgery, complications, and visual acuity outcomes remain unaffected while performing phacoemulsification cataract surgeries with the three-dimensional viewing system when compared to the conventional microscopes. Moreover, the surgeons’ cognitive workload too remains unaffected while utilizing this revolutionary three-dimensional surgical technology.
Screening of Important Factors in the Early Sepsis Stage Based on the Evaluation of ssGSEA Algorithm and ceRNA Regulatory Network
Authors: Huang Liou , Wu Chunrong , Xu Dan , Cui Yuhui , Tang Jianguo 
Published: November 2021

Background: Sepsis is a dysregulated host response to pathogens. Delay in sepsis diagnosis has become a primary cause of patient death. This study determines some factors to prevent septic shock in its early stage, contributing to the early treatment of sepsis. Methods: The sequencing data (RNA- and miRNA-sequencing) of patients with septic shock were obtained from the NCBI GEO database. After re-annotation, we obtained lncRNAs, miRNA, and mRNA information. Then, we evaluated the immune characteristics of the sample based on the ssGSEA algorithm. We used the WGCNA algorithm to obtain genes significantly related to immunity and screen for important related factors by constructing a ceRNA regulatory network. Result: After re-annotation, we obtained 1708 lncRNAs, 129 miRNAs, and 17 326 mRNAs. Also, through the ssGSEA algorithm, we obtained 5 important immune cells. Finally, we constructed a ceRNA regulation network associated with SS pathways. Conclusion: We identified 5 immune cells with significant changes in the early stage of septic shock. We also constructed a ceRNA network, which will help us explore the pathogenesis of septic shock.
The Implementation of Mindfulness-Based Programs in the Swedish Healthcare System—A Qualitative Study
Authors: Andermo Susanne , Crane Rebecca , Niemi Maria 
Published: November 2021

Background: As the provision of Mindfulness-Based Programs (MBPs) in health care settings progresses, more research is needed to develop guidelines and structures for implementation in various contexts. This study is part of a larger project were MBP provision in Sweden is explored. Objective: The objective is to provide knowledge for the next steps of MBP implementation both in Sweden and internationally. The specific aim of the study is to explore how MBP teachers and other relevant stakeholders experience the implementation of MBP. Methods: Qualitative in-depth interviews were conducted with 15 MBP providers and 2 other stakeholders from a range of health care settings in Sweden. Results: The results, presented in 3 themes, provide insights into the factors that are crucial for facilitating or hindering MBP implementation; (1) MBP teachers and their training, including the importance of champion individuals and the benefit and shortcomings of various forms of MBP; (2) Patients and patient referrals, including patient characteristics and referral pathways; (3) Organizational prerequisites to successful implementation, highlighting the importance of financial factors and managers’ and colleagues’ knowledge and acceptance of MBP; and (4) the need for structural changes, including future recommendations on quality assessment and guidelines. Conclusion: This study highlights the need for national guidelines for MBP provision and teacher training pathways, as well as improved availability of teacher training. Also, the benefit of a stepped-care model of MBP provision is indicated by the findings. Finally, increasing awareness of MBPs among referrers, managers, and the public may enable successful implementation.
TSEBRA: transcript selector for BRAKER
Authors: Gabriel Lars , Hoff Katharina J. , Brůna Tomáš , Borodovsky Mark , Stanke Mario 
Published: November 2021

Abstract
Background
BRAKER is a suite of automatic pipelines, BRAKER1 and BRAKER2, for the accurate annotation of protein-coding genes in eukaryotic genomes. Each pipeline trains statistical models of protein-coding genes based on provided evidence and, then predicts protein-coding genes in genomic sequences using both the extrinsic evidence and statistical models. For training and prediction, BRAKER1 and BRAKER2 incorporate complementary extrinsic evidence: BRAKER1 uses only RNA-seq data while BRAKER2 uses only a database of cross-species proteins. The BRAKER suite has so far not been able to reliably exceed the accuracy of BRAKER1 and BRAKER2 when incorporating both types of evidence simultaneously. Currently, for a novel genome project where both RNA-seq and protein data are available, the best option is to run both pipelines independently, and to pick one, likely better output. Therefore, one or another type of the extrinsic evidence would remain unexploited.

Results
We present TSEBRA, a software that selects gene predictions (transcripts) from the sets generated by BRAKER1 and BRAKER2. TSEBRA uses a set of rules to compare scores of overlapping transcripts based on their support by RNA-seq and homologous protein evidence. We show in computational experiments on genomes of 11 species that TSEBRA achieves higher accuracy than either BRAKER1 or BRAKER2 running alone and that TSEBRA compares favorably with the combiner tool EVidenceModeler.

Conclusion
TSEBRA is an easy-to-use and fast software tool. It can be used in concert with the BRAKER pipeline to generate a gene prediction set supported by both RNA-seq and homologous protein evidence.
LPI-HyADBS: a hybrid framework for lncRNA-protein interaction prediction integrating feature selection and classification
Authors: Zhou Liqian , Duan Qi , Tian Xiongfei , Xu He , Tang Jianxin , Peng Lihong 
Published: November 2021

Abstract
Background
Long noncoding RNAs (lncRNAs) have dense linkages with a plethora of important cellular activities. lncRNAs exert functions by linking with corresponding RNA-binding proteins. Since experimental techniques to detect lncRNA-protein interactions (LPIs) are laborious and time-consuming, a few computational methods have been reported for LPI prediction. However, computation-based LPI identification methods have the following limitations: (1) Most methods were evaluated on a single dataset, and researchers may thus fail to measure their generalization ability. (2) The majority of methods were validated under cross validation on lncRNA-protein pairs, did not investigate the performance under other cross validations, especially for cross validation on independent lncRNAs and independent proteins. (3) lncRNAs and proteins have abundant biological information, how to select informative features need to further investigate.

Results
Under a hybrid framework (LPI-HyADBS) integrating feature selection based on AdaBoost, and classification models including deep neural network (DNN), extreme gradient Boost (XGBoost), and SVM with a penalty Coefficient of misclassification (C-SVM), this work focuses on finding new LPIs. First, five datasets are arranged. Each dataset contains lncRNA sequences, protein sequences, and an LPI network. Second, biological features of lncRNAs and proteins are acquired based on Pyfeat. Third, the obtained features of lncRNAs and proteins are selected based on AdaBoost and concatenated to depict each LPI sample. Fourth, DNN, XGBoost, and C-SVM are used to classify lncRNA-protein pairs based on the concatenated features. Finally, a hybrid framework is developed to integrate the classification results from the above three classifiers. LPI-HyADBS is compared to six classical LPI prediction approaches (LPI-SKF, LPI-NRLMF, Capsule-LPI, LPI-CNNCP, LPLNP, and LPBNI) on five datasets under 5-fold cross validations on lncRNAs, proteins, lncRNA-protein pairs, and independent lncRNAs and independent proteins. The results show LPI-HyADBS has the best LPI prediction performance under four different cross validations. In particular, LPI-HyADBS obtains better classification ability than other six approaches under the constructed independent dataset. Case analyses suggest that there is relevance between ZNF667-AS1 and Q15717.

Conclusions
Integrating feature selection approach based on AdaBoost, three classification techniques including DNN, XGBoost, and C-SVM, this work develops a hybrid framework to identify new linkages between lncRNAs and proteins.
Holstein Friesian dairy cattle edited for diluted coat color as a potential adaptation to climate change
Authors: Laible G. , Cole S.-A. , Brophy B. , Wei J. , Leath S. , Jivanji S. , Littlejohn M. D. , Wells D. N. 
Published: November 2021

Abstract
Background
High-producing Holstein Friesian dairy cattle have a characteristic black and white coat, often with large proportions of black. Compared to a light coat color, black absorbs more solar radiation which is a contributing factor to heat stress in cattle. To better adapt dairy cattle to rapidly warming climates, we aimed to lighten their coat color by genome editing.

Results
Using gRNA/Cas9-mediated editing, we introduced a three bp deletion in the pre-melanosomal protein 17 gene (PMEL) proposed as causative variant for the semi-dominant color dilution phenotype observed in Galloway and Highland cattle. Calves generated from cells with homozygous edits revealed a strong color dilution effect. Instead of the characteristic black and white markings of control calves generated from unedited cells, the edited calves displayed a novel grey and white coat pattern.

Conclusion
This, for the first time, verified the causative nature of the PMEL mutation for diluting the black coat color in cattle. Although only one of the calves was healthy at birth and later succumbed to a naval infection, the study showed the feasibility of generating such edited animals with the possibility to dissect the effects of the introgressed edit and other interfering allelic variants that might exist in individual cattle and accurately determine the impact of only the three bp change.
Prognosis and role of clinical and imaging features in patients with malignant pericardial effusion: a single-center study in China
Authors: Wang Shucai , Zhao Jiazheng , Wang Chanchan , Zhang Ning 
Published: November 2021

Abstract
Background
The diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis.

Methods
Patients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included and followed up. The data covered the basic clinical features, imaging findings, treatments and prognosis of patients with MPE, and the factors that may have affected the prognosis were explored.

Results
A total of 216 patients with MPE were included with the median age of 60 years. The most common primary cancer type was lung cancer (73.6%), the most common symptom was dyspnea (62.9%) and the most common abnormal electrocardiogram finding was sinus tachycardia (42.1%). The median survival time of the 216 patients with MPE was 13.7 months. The factors affecting prognosis were echocardiographic fluid signs (HR = 2.37, P = 0.010), electrocardiographic evidence of sinus tachycardia (HR = 1.76, P = 0.006) and echocardiographic evidence of cardiac tamponade (HR = 3.33, P < 0.001).

Conclusions
MPE has complex clinical manifestations and an unsatisfactory prognosis. Echocardiographic fluid signs, electrocardiographic evidence of sinus tachycardia, and echocardiographic evidence of cardiac tamponade are independent risk factors affecting prognosis.
Self-management perspectives of elderly patients with multimorbidity and practitioners - status, challenges and further support needed?
Authors: Breckner Amanda , Roth Catharina , Glassen Katharina , Wensing Michel 
Published: November 2021

Abstract
Background
Patients with multimorbidity (here defined as three or more chronic conditions) require constant treatment and care. Furthermore, they have to manage their health and diseases in daily life. Offering support to patients’ medical self-management is an important task of primary care. The aim of this study was to explore, what further support is needed from the perspective of patients’ and primary care practitioners.

Methods
A qualitative study using individual semi-structed interviews with 17 patients with multimorbidity and 7 practitioners (4 primary care physicians and 3 practice assistants) was conducted in Germany. Data were audio-recorded, pseudonymised and transcribed verbatim. Data analysis was performed using qualitative content analysis to structure data into themes and subthemes. All data were managed and organised in MAXQDA.

Results
The three broad themes: current status, challenges and further support emerged. Patients reported on unfulfilled needs regarding role or emotional management, like coping with loneliness, loss of independence and, changing habits. The importance of social contact was highlighted by patients and practitioners. Patients articulated further support from their primary care practitioners on coping with the disease. Practitioners’ wished for further support in aspects of social participation, public transport, and community resources.

Conclusion
Challenges regarding self-management of elderly patients with multimorbidity may be addressed by harnessing social support and community initiatives.