bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of distance from semi-natural habitat on fall armyworm (Spodoptera frugiperda, J. E. Smith) and its potential natural enemies in Ghana
Authors: Jordon Matthew W. , Hackett Talya D. , Aboagye-Antwi Fred , Eziah Vincent Y. , Lewis Owen T. 
Published: October 2021

AbstractInsect crop pests are a major threat to food security in sub-Saharan Africa. Configuration of semi-natural habitat within agricultural landscapes has the potential to enhance biological pest control, helping to maintain yields whilst minimising the negative effects of pesticide use. Fall armyworm (Spodoptera frugiperda, J. E. Smith) is an increasingly important pest of maize in sub-Saharan Africa, with reports of yield loss between 12 and 45%. We investigated the patterns of fall armyworm leaf damage in maize crops in Ghana, and used pitfall traps and dummy caterpillars to assess the spatial distribution of potential fall armyworm predators. Crop damage from fall armyworm at our study sites increased significantly with distance from the field edge, by up to 4% per m. We found evidence that Araneae activity, richness and diversity correspondingly decreased with distance from semi-natural habitat, although Hymenoptera richness and diversity increased. Our preliminary findings suggest that modifying field configuration to increase the proximity of maize to semi-natural habitat may reduce fall armyworm damage and increase natural enemy activity within crops. Further research is required to determine the level of fall armyworm suppression achievable through natural enemies, and how effectively this could safeguard yields.
Rapports à autrui et personnalité de base dans les premiers travaux de Mikel Dufrenne
Authors: Chamois Camille 
Published: October 2021

RésuméCet article souligne l'originalité et la pertinence des premiers travaux de Mikel Dufrenne (notamment publiés entre 1946 et 1953) pour les sciences humaines contemporaines. Sous l'influence de Georges Gurvitch, Dufrenne s'est en effet intéressé de près à l'anthropologie culturelle américaine et notamment au concept de « personnalité de base » d'Abram Kardiner, auquel il tente de donner une consistance philosophique à partir, d'une part, de la tradition transcendantale kantienne et, d'autre part, de la théorie du Mitsein heideggérienne. Nous montrons que ce projet se heurte à la question proprement psychologique de l'historicité des catégories de l'expérience.
Efficiency of fertilization with coated urea in the cultivation of cactus pear under rainfed conditions in Brazilian savannah
Authors: Magalhães R. M. F. , Edvan R. L. , Ratke R. F. , de. Oliveira M. E. , de. M. Carvalho C. B. , Araújo J. S. , da. C. Araújo D. L. , do. Nascimento R. R. 
Published: October 2021

AbstractCactus pear is an important species for animal feeding in the regions of dry climate. There is no information on the fertilization with coated urea in the cultivation of cactus pear under rainfed conditions in the savannah region. The aim of the current study was to evaluate the forage potential of Nopalea cochenillifera variety Doce in yellow latosol under rainfed conditions in the Brazilian savannah, comparing the fertilization with urea and coated urea in different levels. A randomized block design was adopted, in a 2 × 4 × 2 factorial scheme, with the factors corresponding to two sources of nitrogen (urea and urea coated with polymers, N+), four levels of nitrogen (0, 60, 120 and 240 kg/ha/year) and two harvests (year I and year II). The plants were evaluated after 1 year of growth, in each year of evaluation, regarding the characteristics of growth, production, chemical and mineral composition and nutritional value. The level of 240 kg/ha provided higher emission of cladodes per plant (17.33 and 18.17), respectively, for N+ and urea. The highest nitrogen use efficiency was found in the level of 60 kg N/ha (142 kg/ha/year). NFC values were 3.5 g/kg dry matter (DM) higher when the cactus pear was fertilized with urea in year I and 5.4 g/kg DM in year II. The use of conventional urea promoted better results of agronomic and nutritional characteristics of the cactus pear, under rainfed regime, when compared to the use of urea coated with polymers.
The Political Economy of China's Dramatically Improved Coal Safety Record
Authors: Wright Tim 
Published: October 2021

AbstractChina's coal safety has improved dramatically since 2003. This article will present the official data and conclude that it is almost impossible that the figures conceal a situation where there has not been remarkable improvement. Structural factors including China's level of economic development, changes in the labour market and the economic health of the industry have played an important role, but state commitment and policies have been central at least to the speed and magnitude of the improvement.
Morphological and electrophysiological specializations of photoreceptors in the love spot of hover fly Volucella pellucens
Authors: Ignatova Irina I. , Miinalainen Ilkka , Frolov Roman V. 
Published: October 2021

Abstract
Studies of functional variability in the compound eyes of flies reveal superior temporal resolution of photoreceptors from the frontal areas that mediate binocular vision, and in males mate recognition and pursuit. However, the mechanisms underlying differences in performance are not known. Here, we investigated properties of hover fly Volucella pellucens photoreceptors from two regions of the retina, the frontal-dorsal “love spot” and the lateral one. Morphologically, the microvilli of the frontal-dorsal photoreceptors were relatively few in number per rhabdomere cross-section, short and narrow. In electrophysiological experiments involving stimulation with prolonged white-noise and natural time intensity series, frontal-dorsal photoreceptors demonstrated comparatively high corner frequencies and information rates. Investigation of possible mechanisms responsible for their superior performance revealed significant differences in the properties of quantum bumps, and, unexpectedly, relatively high absolute sensitivity of the frontal-dorsal photoreceptors. Analysis of light adaptation indicated that photoreceptors from two regions adapt similarly but because frontal-dorsal photoreceptors were depolarized much stronger by the same stimuli than the lateral photoreceptors, they reached a deeper state of adaptation associated with higher corner frequencies of light response. Recordings from the photoreceptor axons were characterized by spike-like events that can significantly expand the frequency response range. Seamless integration of spikes into the graded voltage responses was enabled by light adaptation mechanisms that accelerate kinetics and decrease duration of depolarizing light response transients.
Comparative Cellular Localization of Sugar Residues in Bull (Bos taurus) and Donkey (Equus asinus) Testes Using Lectin Histochemistry
Authors: Gewaily Mahmoud S , Kassab Mohamed , Aboelnour Asmaa , Almadaly Essam A , Noreldin Ahmed E 
Published: October 2021

AbstractLectins are glycoproteins of a non-immune origin often used as histochemical reagents to study the distribution of glycoconjugates in different types of tissues. In this study, we performed a comparative cellular localization of sugar residues in bull and donkey testes using immunofluorescent lectin histochemistry. We inspected the cellular localization of the glycoconjugates within the testes using 11 biotin-labeled lectins (LCA, ConA, PNA, WGA, DBA, SBA, ECA, BPL, PTL-II, UEA-1, and PHA-E4) classified under six groups. Although the basic testicular structure in both species was similar, the cellular components showed different lectin localization patterns. The statistical analysis revealed no significant association between the intensity of labeling and different variables, including group and type of lectin and type of cell examined, at p &lt; 0.05. However, a stronger response tended to occur in the donkey than in the bull testes (odds ratio: 1.3). These findings may be associated with the different cellular compositions of the glycoproteins and modification changes during spermatogenesis. Moreover, glycoconjugate profiling through lectin histochemistry can characterize some cell-type selective markers that will be helpful in studying bull and donkey spermatogenesis.
Late Holocene Climate Changes in the Altai Region Based on a First High‐Resolution Biomarker Isotope Record From Lake Khar Nuur
Authors: Bliedtner Marcel , Struck Julian , Strobel Paul , Salazar Gary , Szidat Sönke , Bazarradnaa Enkhtuya , Lloren Ronald , Dubois Nathalie , Zech Roland 
Published: October 2021

AbstractThe Late Holocene marks a substantial cultural and economic transition in the eastern Eurasian Steppe and Altai Region with the dispersal of nomadic pastoralism. So far, paleoclimate conditions during this time remain unclear and controversial. Here, we present a high‐resolution 4.2 ka paleoclimate record from Lake Khar Nuur in the Mongolian Altai that is based on lake sediment proxies and biomarker compound‐specific δ2H analyses. Our results document increased aridity before ∼3.7 cal. ka BP, followed by two pronounced phases of warm and wet conditions from ∼3.5–2.8 to ∼2.3–1.5 cal. ka BP, and a strong increase in aridity since ∼1.5 cal. ka BP. Phases of warmer and wetter conditions coincide with a negative North Atlantic Oscillation, which has been responsible for advecting moisture into the region by more southerly‐displaced Westerlies and possibly favored the expansion of mobile nomadic pastoralism in the region.
Surface Salinity Under Transitioning Ice Cover in the Canada Basin: Climate Model Biases Linked to Vertical Distribution of Fresh Water
Authors: Rosenblum E. , Fajber R. , Stroeve J. C. , Gille S. T. , Tremblay L. B. , Carmack E. C. 
Published: October 2021

AbstractThe Canada Basin has exhibited a significant trend toward a fresher surface layer and thus a more stratified upper‐ocean over the past three decades. State‐of‐the‐art ice‐ocean models, by contrast, tend to simulate a surface layer that is saltier and less stratified than observed. Here, we examine decadal changes to seasonal processes that may contribute to this wide‐reaching model bias using climate model simulations from the Community Earth System Model and below‐ice observations from the Arctic Ice Dynamics Joint Experiment in 1975 and Ice Tethered Profilers in 2006–2012. In contrast to the observations, the models simulate salinity profiles that show relatively little variation between 1975 and 2012. We demonstrate that this bias can be mainly attributed to unrealistically deep vertical mixing in the model, creating a surface layer that is saltier than observed. The results provide insight for climate model improvement with broad implications for Arctic sea ice and ecosystem dynamics.
Fault Trace Corrugation and Segmentation as a Measure of Fault Structural Maturity
Authors: Manighetti I. , Mercier A. , De Barros L. 
Published: October 2021

AbstractAs faults grow over time and become more “mature,” some of their geometrical and mechanical properties evolve, and these changes modify earthquake behavior. It is thus of prime importance to know the degree of structural maturity of a fault that is likely to produce large earthquakes. Although this concept is extensively used, there is no common definition or metric to measure the structural maturity of a fault. We analyzed the heterogeneity of the surface traces of 13 large seismogenic faults whose maturity is known qualitatively. We measured the corrugations and step‐over segmentation of the traces from ∼100 m to the fault length scale. Corrugations and some properties of the segmentation are found to vary with fault structural maturity. We provide scaling relationships that quantify the structural maturity of a fault based on its surface trace. These results should help in parameterizing source faults in earthquake models.
Do Atlantic‐European Weather Regimes Physically Exist?
Authors: Hochman Assaf , Messori Gabriele , Quinting Julian F. , Pinto Joaquim G. , Grams Christian M. 
Published: October 2021

AbstractThe subseasonal variability of the extratropical large‐scale atmospheric flow is characterized by recurrent or quasi‐stationary circulation anomalies, termed weather regimes. Despite the usefulness of these regimes in numerous meteorological and socioeconomic applications, there is an ongoing debate as to whether they represent physical modes of the atmosphere, or are merely useful statistical categorizations. Here, we answer this question for wintertime Atlantic‐European regimes. We argue that dynamical systems theory applied to a refined regime definition provides strong evidence in support of most weather regimes being physically meaningful. This finding underpins the broad relevance of weather regimes, for understanding the response of the atmosphere to external forcing, supporting subseasonal weather forecasting, and down scaling of climate projections.
Estimating Effective Normal Stress During Slow Slip Events From Slip Velocities and Shear Stress Variations
Authors: Kobayashi Takuma , Sato Toshinori 
Published: October 2021

AbstractTheoretical analyses using a rate‐ and state‐dependent friction law have shown quasistatic and stable slip behaviors following velocity weakening. We estimated spatiotemporal slip distributions for six slow slip events (SSEs) off the Boso Peninsula, Japan, from Global Navigation Satellite System data and plotted their shear stress variations vs. slip velocity, here called “trajectories.” Most trajectories are similar to theoretical stable trajectories, implying that the Boso SSEs represent a quasistatic and stable process, and that the gradient of the trajectories during slip acceleration is equal to the product of the friction coefficients of the slipping plates (a–b) and the effective normal stress (). Taking (a–b) = −0.003, we estimate that the effective normal stresses during the SSEs were 10–50 MPa at 12.5–20.5 km depth. These values are much smaller than the lithostatic pressures at those depths, implying high pore pressures on the slow slip interface.
Assessing Multi‐Stream Radiative Transfer Schemes for the Calculation of Aerosol Radiative Forcing in the Martian Atmosphere
Authors: Chen‐Chen H. , Pérez‐Hoyos S. , Sánchez‐Lavega A. 
Published: October 2021

AbstractThe atmosphere of Mars presents a strong response to aerosol radiative forcing compared to that of the Earth, thus atmospheric models should have accurate radiative transfer algorithms for the simulation of temperatures and circulation. In this work, we evaluate the radiative effects of dust aerosol calculated by different radiative transfer schemes and the influence of dust properties in these calculations. Two‐stream solutions were compared with multistream discrete ordinate methods. Fluxes and heating rates were evaluated for a variety of atmospheric conditions, including dust storms. The results show that in low‐to‐medium dust opacity scenarios, the highly efficient two‐stream methods provide accurate estimations, with heating rate errors of less than 2 K/sol. These errors increase with opacity, when differences of 20 K/sol are reached, which may be relevant in the simulations of temperature fields and atmospheric circulation under regional and global dust storm conditions. In such cases, the use of four‐stream or higher order methods may be required, although accuracy improvements for eight‐ or higher‐stream schemes were negligible. The influence of dust particle properties in aerosol radiative forcing estimations is mainly due to the particle size, where variations of 20% of the effective radius resulted in differences of 5 K/sol; the shape of the particles showed a minor impact, with differences of <2 K/sol. The results of this study contribute to quantification of the uncertainties in current Mars climate models and may help modellers to select the appropriate approach depending on the scenario.
Combined Drug Targeting of p53-dependent and -independent Pathways Depletes Myelofibrosis Hematopoietic Stem/Progenitor Cells
Authors: Lu Min , Xia Lijuan , Elmansy Nada , Clementelli Cara , Tremblay Douglas , Hoffman Ronald 
Published: October 2021

AbstractCurrent therapy for myelofibrosis (MF) results in a limited prolongation of patient survival. In order to improve treatment outcomes, we developed a strategy to effectively deplete MF hematopoietic stem/progenitor cells (HSPCs). In the present study, an imipridone, ONC201, was combined with RG7112, an antagonist of MDM2, a p53 negative regulator, to activate downstream events of the p53 and TNF-related apoptosis-inducing ligand (TRAIL)/death receptor (DR) pathways. As compared to treatment with the individual drugs, the combination of ONC201 and RG7112 promoted greater degrees of apoptosis of MF CD34+ cells through activation of both p53-dependent and -independent pathways. Importantly, treatment with ONC201-RG7112 not only decreased the number of JAK2V617F+ and calreticulin mutated colonies assayed from MF CD34+ cells, but allowed for the persistence or appearance of JAK2 wild type colonies. Treatment with ONC201 combined with RG7112 could be a potentially effective strategy for treating MF patients.
Cross-species anxiety tests in psychiatry: pitfalls and promises
Authors: Bach Dominik R. 
Published: October 2021

AbstractBehavioural anxiety tests in non-human animals are used for anxiolytic drug discovery, and to investigate the neurobiology of threat avoidance. Over the past decade, several of them were translated to humans with three clinically relevant goals: to assess potential efficacy of candidate treatments in healthy humans; to develop diagnostic tests or biomarkers; and to elucidate the pathophysiology of anxiety disorders. In this review, we scrutinise these promises and compare seven anxiety tests that are validated across species: five approach-avoidance conflict tests, unpredictable shock anticipation, and the social intrusion test in children. Regarding the first goal, three tests appear suitable for anxiolytic drug screening in humans. However, they have not become part of the drug development pipeline and achieving this may require independent confirmation of predictive validity and cost-effectiveness. Secondly, two tests have shown potential to measure clinically relevant individual differences, but their psychometric properties, predictive value, and clinical applicability need to be clarified. Finally, cross-species research has not yet revealed new evidence that the physiology of healthy human behaviour in anxiety tests relates to the physiology of anxiety symptoms in patients. To summarise, cross-species anxiety tests could be rendered useful for drug screening and for development of diagnostic instruments. Using these tests for aetiology research in healthy humans or animals needs to be queried and may turn out to be unrealistic.
Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain
Authors: Yoon Gwangho , Lim Yeong-Hwan , Jo Danbi , Ryu Juhee , Song Juhyun , Kim Young-Kook 
Published: October 2021

AbstractMetabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the brain cortices of high-fat-fed obese mice. In this study, we scrutinized a conserved and neuron-specific circRNA, circTshz2-2, which affects neuronal cell cycle and spatial memory in the brain. Transcriptomic and cellular analysis indicated that circTshz2-2 dysregulation altered the expression of cell division-related genes and induced cell cycle arrest at the G2/M phase of the neuron. We found that circTshz2-2 bound to the YY1 transcriptional complex and suppressed Bdnf transcription. Suppression of circTshz2-2 increased BDNF expression and reduced G2/M checkpoint proteins such as Cyclin B2 and CDK1 through BDNF/TrkB signaling pathway, resulting in cell cycle arrest and neurite elongation. Inversely, overexpression of circTshz2-2 decreased BDNF expression, induced cell cycle proteins, and shortened the neurite length, indicating that circTshz2-2 regulates neuronal cell cycle and structure. Finally, we showed that circTshz2-2 affects spatial memory in wild-type and obese mice. Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits.
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients
Authors: Yu Yuanling , Wang Meiyu , Zhang Xiaoai , Li Shufen , Lu Qingbin , Zeng Haolong , Hou Hongyan , Li Hao , Zhang Mengyi , Jiang Fei , Wu Jiajing , Ding Ruxia , Zhou Zehua , Liu Min , Si Weixue , Zhu Tao , Li Hangwen , Ma Jie , Gu Yuanyuan , She Guangbiao , Li Xiaokun , Zhang Yulan , Peng Ke , Huang Weijin , Liu Wei , Wang Youchun 
Published: October 2021

AbstractAntibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of antibody regulated immune responses mediated through the Fc fragment. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered ADCC responses contributes to COVID-19 disease development is currently not well understood. To understand the potential correlation between ADCC responses and COVID-19 disease development, we analyzed the ADCC activity and neutralizing antibody response in 255 individuals ranging from asymptomatic to fatal infections over 1 year post disease. ADCC was elicited by 10 days post-infection, peaked by 11–20 days, and remained detectable until 400 days post-infection. In general, patients with severe disease had higher ADCC activities. Notably, patients who had severe disease and recovered had higher ADCC activities than patients who had severe disease and deceased. Importantly, ADCC activities were mediated by a diversity of epitopes in SARS-COV-2-infected mice and induced to comparable levels against SARS-CoV-2 variants of concern (VOCs) (B.1.1.7, B.1.351, and P.1) as that against the D614G mutant in human patients and vaccinated mice. Our study indicates anti-SARS-CoV-2 ADCC as a major trait of COVID-19 patients with various conditions, which can be applied to estimate the extra-neutralization level against COVID-19, especially lethal COVID-19.
Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients
Authors: Theodoraki M.-N. , Laban S. , Jackson E. K. , Lotfi R. , Schuler P. J. , Brunner C. , Hoffmann T. K. , Whiteside T. L. , Hofmann L. 
Published: October 2021

Abstract
Background
Head and neck cancers (HNSCC) are highly immunosuppressive. Plasma-derived exosomes of HNSCC patients carry immunomodulatory molecules, and their cargo correlates with clinical parameters. Here, we evaluated the exosomal molecular profile for early detection of treatment failure in locally advanced HNSCC patients treated with conventional therapy.

Methods
Plasma from 17 HNSCC patients was collected before, during, and after treatment by surgery with adjuvant (chemo)radiation and at recurrence. Exosomes were isolated by size-exclusion chromatography. Total exosomal protein (TEP) was used to estimate exosome load and on-bead flow cytometry to evaluate relative fluorescence intensity (RFI) of tumour-associated and immunoregulatory proteins on exosomes. Exosomal effects on the activity of and adenosine production by T cells was assessed by flow cytometry and mass spectrometry.

Results
TEP and the ratio of tumour-/immune-cell-derived exosomes varied during and after therapy with an overall decrease in the tumour-free follow-up but an increase at recurrence. RFI values of immunoregulatory proteins on exosomes, their ability for T cell inhibition and adenosine production changed during and after therapy. PD-L1 was the earliest discriminator for treatment failure and disease-free survival.

Conclusions
Monitoring of plasma exosomes during therapy represents a promising opportunity for early detection of treatment failure and risk stratification to delay/avoid recurrence.