bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking perceived price fairness, customer satisfaction, trust, and loyalty: A structural equation modeling of Facebook‐based e‐commerce in Bangladesh
Authors: Hride Fabliha Tasnim , Ferdousi Farhana , Jasimuddin Sajjad M. 
Published: November 2021

AbstractThe data from the current research forms part of a broader study that analyzes the association between perceived price fairness, customer satisfaction, trust, and loyalty among social‐commerce users. This study examines their relationship in the context of Facebook‐based e‐commerce in Bangladesh. Based on data obtained from 171 respondents to a self‐administered questionnaire, it uses structural equation modeling and AMOS 21 software to test a research model and seven hypotheses. The study also tests and validates a Western instrument in the Asian context. In line with previous work, it reveals that perceived price fairness is positively related to customer loyalty, customer satisfaction, and trust, and that customer loyalty is also positively related to customer satisfaction and trust. However, it shows that customer satisfaction and trust do not mediate the relationship between perceived price fairness and customer loyalty. It provides practitioners with an understanding of key constructs in various forms that are causing the variation in customer loyalty. The research also provides useful insights for managers who wish to increase customer loyalty and offers guidance to those that intend to attract customers toward shopping, particularly via Facebook.
Prediction of the ripening stages of papayas using discriminant analysis and support vector machine algorithms
Authors: Zulkifli Nurazwin , Hashim Norhashila , Harith Hazreen Haizi , Mohamad Shukery Mohamad Firdza , Onwude Daniel I. 
Published: November 2021

AbstractBACKGROUNDEvaluation of the quality properties of papaya becomes essential due to the acceleration of the fruit shelf‐life senescence and the deterioration factor of the expected postharvest operations. In this study, the colour features in RGB, normalised RGB, HSV and L*a*b* channels were extracted and correlated with mechanical properties, moisture content (MC), total soluble solids (TSS) and pH for the prediction of quality properties at five ripening stages of papaya (R1–R5).RESULTSThe mean values of colour features in RGB , normalised RGB HSV , and L*a*b* were the best estimator for predicting TSS with R2 ≥ 0.90. All colour channels also showed satisfactory accuracies of R2 ≥ 0.80 in predicting the bioyield force, apparent modulus and mean force. The highest average classification accuracy was obtained using linear discriminant analysis (LDA) with an average accuracy of more than 82%. The study showed that LDA, linear support vector machine, quadratic discriminant analysis and quadratic support vector machine obtained the correct classification of up to 100% for R5, whereas R1, R2, R3 and R4 gave classification accuracies in the range 83.75–91.85%, 85.6–90.25%, 85.75–90.85% and 77.35–87.15%, respectively. This indicates that R5 colour information was obviously different from R1–R4. The mean values of the HSV channel indicated the best performance to predict the ripening stages of papaya, compared to RGB, normalised RGB and L*a*b* channels, with an average classification accuracy of more than 80%.CONCLUSIONThe study has shown the versatility of a machine vision system in predicting the quality changes in papaya. The results showed that the machine vision system can be used to predict the ripening stages as well as classifying the fruits into different ripening stages of papayas. © 2021 Society of Chemical Industry.
Warming combined with experimental eutrophication intensifies lake phytoplankton blooms
Authors: Salk Kateri R. , Venkiteswaran Jason J. , Couture Raoul‐Marie , Higgins Scott N. , Paterson Michael J. , Schiff Sherry L. 
Published: November 2021

AbstractPhytoplankton blooms are a global water quality issue, and successful management depends on understanding their responses to multiple and interacting drivers, including nutrient loading and climate change. Here, we examine a long‐term dataset from Lake 227, a site subject to a fertilization experiment (1969–present) with changing nitrogen:phosphorus (N:P) ratios. We applied a process‐oriented model, MyLake, and updated the model structure with nutrient uptake kinetics that incorporated shifting N:P and competition among phytoplankton functional groups. We also tested different temperature and P‐loading scenarios to examine the interacting effects of climate change and nutrient loading on phytoplankton blooms. The model successfully reproduced lake physics over 48 yr and the timing, overall magnitude, and shifting community structure (diazotrophs vs. non‐diazotrophs) of phytoplankton blooms. Intra‐ and interannual variability was captured more accurately for the P‐only fertilization period than for the high N:P and low N:P fertilization periods, highlighting the difficulty of modeling complex blooms even in well‐studied systems. A model scenario was also run which removed climate‐driven temperature trends, allowing us to disentangle concurrent drivers of blooms. Results showed that increases in water temperature in the spring led to earlier and larger phytoplankton blooms under climate change than under the effects of nutrient fertilization alone. These findings suggest that successful lake management efforts should incorporate the effects of climate change in addition to nutrient reductions, including intensifying and/or expanding monitoring periods and incorporating climate change into uncertainty estimates around future conditions.
Air Purification Using Polymer Fiber Filters
Authors: Chai Mengnan , Tong Wangshu , Wang Zhihao , Zhao Shifeng , Zhang Yihe 
Published: November 2021

AbstractPolymer fiber filters, with their high surface area, low cost, and easy large‐scale manufacturing, are widely used in air purification. These filters have been combined with various types of functional nanoparticles to endow them with electrostatic adsorption, photocatalysis, electrocatalysis, photoelectrocatalysis, or antibacterial properties, and improve their filtering performance. In this study, a summary of the research on single polymer and polymer composite filters for highly efficient air purification is presented. In single polymer filters, polar groups in the polymer chains, a rich porous structure, and electret process improve their removal capability. In polymer composite filters, metal–organic frameworks, porous particles, and electret materials as fillers improve the physical adsorption of the materials, while the use of photocatalysts, electrocatalysts, photoelectrocatalysts, and antibacterial agents as functional fillers endows the filters with additional chemical reactions for the complete degradation of gas and microorganism pollutants. Finally, the challenges that remain in the development of polymer filters for use in air purification are also discussed in terms of material type and fabrication technology. It is expected that polymer filters with tunable surface properties and multifunctions can realize highly efficient air purification with low energy consumption.
Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention
Authors: Hu Zuomin , Li Mengyuan , Cao Yunyun , Akan Otobong Donald , Guo Tianyi , Luo Feijun 
Published: November 2021

AbstractCancer is a serious public health problem in the world and a major disease affecting human health. Dietary polyphenols have shown good potential in the treatment of various cancers. It is worth noting that cancer cells usually exhibit metabolic abnormalities of high glucose intake and inefficient utilization. AMPK is the key molecule in the regulation of energy metabolism and is closely related with obesity and diabetes. Recent studies indicate that AMPK also plays an important role in cancer prevention and regulating cancer‐related genes and pathways, and dietary polyphenols can significantly regulate AMPK activity. In this review, the progress of dietary polyphenols preventing carcinogenesis via AMPK pathway is systemically summarized. From the viewpoint of interfering energy metabolism, the anti‐cancer effects of dietary polyphenols are explained. AMPK pathway modulated by different dietary polyphenols affects pathways and target genes are summarized. Dietary polyphenols exert anti‐cancer effect through the target molecules regulated by AMPK, which broadens the understanding of polyphenols anti‐cancer mechanisms and provides value reference for the investigators of the novel field.
Disposable point‐of‐care portable perfusion phantom for quantitative DCE‐MRI
Authors: Holland Martin D. , Morales Andres , Simmons Sean , Smith Brandon , Misko Samuel R. , Jiang Xiaoyu , Hormuth David A. , Christenson Chase , Koomullil Roy P. , Morgan Desiree E. , Li Yufeng , Xu Junzhong , Yankeelov Thomas E. , Kim Harrison 
Published: November 2021

AbstractPurposeTo develop a disposable point‐of‐care portable perfusion phantom (DP4) and validate its clinical utility in a multi‐institutional setting for quantitative dynamic contrast‐enhanced magnetic resonance imaging (qDCE‐MRI).MethodsThe DP4 phantom was designed for single‐use and imaged concurrently with a human subject so that the phantom data can be utilized as the reference to detect errors in qDCE‐MRI measurement of human tissues. The change of contrast‐agent concentration in the phantom was measured using liquid chromatography‐mass spectrometry. The repeatability of the contrast enhancement curve (CEC) was assessed with five phantoms in a single MRI scanner. Five healthy human subjects were recruited to evaluate the reproducibility of qDCE‐MRI measurements. Each subject was imaged concurrently with the DP4 phantom at two institutes using three 3T MRI scanners from three different vendors. Pharmacokinetic (PK) parameters in the regions of liver, spleen, pancreas, and paravertebral muscle were calculated based on the Tofts model (TM), extended Tofts model (ETM), and shutter speed model (SSM). The reproducibility of each PK parameter over three measurements was evaluated with the intraclass correlation coefficient (ICC) and compared before and after DP4‐based error correction.ResultsThe contrast‐agent concentration in the DP4 phantom was linearly increased over 10 min (0.17 mM/min, measurement accuracy: 96%) after injecting gadoteridol (100 mM) at a constant rate (0.24 ml/s, 4 ml). The repeatability of the CEC within the phantom was 0.997 when assessed by the ICC. The reproducibility of the volume transfer constant, Ktrans, was the highest of the PK parameters regardless of the PK models. The ICCs of Ktrans in the TM, ETM, and SSM before DP4‐based error correction were 0.34, 0.39, and 0.72, respectively, while those increased to 0.93, 0.98, and 0.86, respectively, after correction.ConclusionsThe DP4 phantom is reliable, portable, and capable of significantly improving the reproducibility of qDCE‐MRI measurements.
Influence of food images with different macronutrient compositions on serum ghrelin levels: Analysis in healthy males
Authors: Rademacher Jan‐Gerd , Raddatz Dirk , Ellrott Thomas 
Published: November 2021

AbstractObjectiveSerum concentrations of the orexigenic hormone ghrelin fluctuate in anticipation of food intake. Moreover, presentation of food images causes an increase in serum ghrelin levels. Thus, the visual system may have a quantifiable role in the development of hunger via the endocrine system. The influence of macronutrient visualization on ghrelin has not yet been investigated.MethodsIn four separate sessions, ghrelin concentrations, insulin, and glucose levels were compared before and after the presentation of different pictures to 14 male participants. Pictures included neutral, non‐food‐related items or isocaloric dishes whose macronutrient composition corresponded predominately to protein/fat, simple carbohydrates, or complex carbohydrates.ResultsWhile pre/post ghrelin concentrations numerically increased in all sessions, significant increases were only observed following neutral and protein/fat pictures. The differences were not significant between food groups and compared to neutral images. Insulin levels decreased in all groups, but no significant differences were observed between sessions. The glucose concentrations were within the euglycemic range.ConclusionThe results did not reproduce the induction of ghrelin secretion in different food images. Therefore, it is unclear whether the visual perception of food influences ghrelin secretion or whether separation into macronutrients changes the hormone response. Further research is required to differentiate the interactions of sensory‐specific satiety.
Development of an immunochromatographic test strip for the rapid detection of aristolochic acid A in herbal medicinal materials
Authors: Chen Xianrui , Huang Ting , Huang Zhibing , Han Quanbin 
Published: November 2021

AbstractIntroductionPlants containing aristolochic acid and its derivatives are nephrotoxic, mutagenic, and carcinogenic to humans; chronic diet poisoning caused by the aristolochic acid is the cause of endemic (Balkan) nephropathy and related cancers.ObjectiveTo develop a colloidal gold immunochromatographic test strip (ICS) based on the competitive format for the rapid detection of aristolochic acid A (AA‐A) in herbal medicinal materials.Materials and methodsFor the ICS based on gold nanoparticles (AuNPs), the antigen [AA‐A–bovine serum albumin (BSA)], and goat anti‐mouse IgG were drawn on the nitrocellulose membrane as the test line (T line) and the control line (C line), respectively. Monoclonal antibody (MAb)–AuNP conjugates were sprayed onto the conjugate pad. The sensitivity of the ICS was 6 ng/mL, and the test was completed in 10 min. The analysis of AA‐A in traditional Chinese medicine samples showed that the ICS results were in good agreement with those obtained by high‐performance liquid chromatography methods.ConclusionThese results demonstrated that the ICS test could be used as a reliable, rapid, cost‐effective, and convenient qualitative tool for on‐site screening techniques to detect AA‐A in herbal medicinal materials without any special instrumentation.
Two cases of microvillus inclusion disease caused by MYO5B deficiency with prenatal abnormalities
Authors: Lu Jiaqi , Qi Yiming , Ding Hongke , Yin Aihua 
Published: November 2021

AbstractBackgroundsMicrovillus inclusion disease (MVID) characterizes as intractable life‐threatening watery diarrhea malnutrition after birth.Materials & MethodsHere we describe two patients with prenatal ultrasound findings of bowel dilation or increased amniotic fluid volume presented intractable diarrhea after birth. Exome sequencing and Intestinal biopsy were performed for the patients and their parents to reveal the underlying causes. The mutations were verified by Sanger sequencing and quantitative polymerase chain reaction.ResultsExome sequencing revealed that both of the patients carrying MYO5B compound heterozygote mutations that were inherited from their parents.ConclusionHere we describe two cases with MVID caused by MYO5B deficiency, which was the most common caused with prenatal ultrasound findings of bowel dilation and increased amniotic fluid volume. Due to the lack of effective curative therapies, early diagnosis even in prenatal of MVID can provide parents with better genetic counseling on the fetal prognosis.
Patient characteristics and safety outcomes in new users of ticagrelor and clopidogrel—An observational cohort study in Sweden
Authors: Linder Marie , Andersen Morten 
Published: November 2021

AbstractPurposeWe aimed to describe characteristics of new users of ticagrelor or clopidogrel following a recent coronary event, and to compare incidences of selected safety outcomes.MethodsThis observational cohort study used data from national Swedish registers. Patients first dispensed ticagrelor or clopidogrel (June 2011–December 2013) were identified from the Prescribed Drug Register and followed until censoring or 31 December 2014. Cohorts were restricted to patients with a recent coronary event‐related hospital contact identified in the Patient Register.ResultsThe study included 45 987 unique, naïve users of ticagrelor (73% men; mean age 66 years) or clopidogrel (69% men; mean age 69 years). Corresponding to indication, diagnoses before initiation were acute coronary syndrome (93%), myocardial infarction (76%), and percutaneous coronary intervention (69%). The most common medications used in the year before initiation of study therapy were antithrombotic agents (clopidogrel 62%, ticagrelor 43%), mainly low‐dose acetylsalicylic acid. Ticagrelor users had a higher incidence (per 1000 person‐years) of respiratory bleeding (24.6 [95% confidence interval (CI): 22.1–27.3]; vs clopidogrel users: 14.4 [13.1–15.8]) and dyspnea (25.9 [23.3–28.7]; vs clopidogrel users: 16.8 [15.4–18.4]). Epistaxis accounted for 83–93% of respiratory bleeds. Adjusted analyses found increased risks of gout and acute renal failure with ticagrelor.ConclusionsClopidogrel users were older with a higher prevalence of concomitant medications than ticagrelor users. Our study showed increased incidences of dyspnea and respiratory bleeding (mainly epistaxis) among current ticagrelor users compared with clopidogrel users, and increased risks of gout and acute renal failure after adjustment.
Voltage‐activated complexation of α‐synuclein with three diverse β‐barrel channels: VDAC, MspA, and α‐hemolysin
Authors: Hoogerheide David P. , Gurnev Philip A. , Rostovtseva Tatiana K. , Bezrukov Sergey M. 
Published: November 2021

AbstractVoltage‐activated complexation is the process by which a transmembrane potential drives complex formation between a membrane‐embedded channel and a soluble or membrane‐peripheral target protein. Metabolite and calcium flux across the mitochondrial outer membrane was shown to be regulated by voltage‐activated complexation of the voltage‐dependent anion channel (VDAC) and either dimeric tubulin or α‐synuclein (αSyn). However, the roles played by VDAC's characteristic attributes—its anion selectivity and voltage gating behavior—have remained unclear. Here, we compare in vitro measurements of voltage‐activated complexation of αSyn with three well‐characterized β‐barrel channels—VDAC, MspA, and α‐hemolysin—that differ widely in their organism of origin, structure, geometry, charge density distribution, and voltage gating behavior. The voltage dependences of the complexation dynamics for the different channels are observed to differ quantitatively but have similar qualitative features. In each case, energy landscape modeling describes the complexation dynamics in a manner consistent with the known properties of the individual channels, while voltage gating does not appear to play a role. The reaction free energy landscapes thus calculated reveal a non‐trivial dependence of the αSyn/channel complex stability on the surface density of αSyn.
Cover Image
Authors: Qin Tiantian , Zhao Jinzhu , Liu Xiaojie , Li Leilei , Zhang Xueyan , Shi Xiaoli , Ke Yu , Liu Weihua , Huo Junfeng , Dong Yalong , Shen Yiwei , Li Yanyu , He Mingjing , Han Shuhua , Li Linlin , Pan Chengxue , Wang Cong 
Published: November 2021

The cover image is based on the Research Article Luteolin combined with low‐dose paclitaxel synergistically inhibits epithelial–mesenchymal transition and induces cell apoptosis on esophageal carcinoma in vitro and in vivo by Tiantian Qin et al., https://doi.org/10.1002/ptr.7267.
image
Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double‐blind, placebo‐controlled trial
Authors: Banazadeh Mohammad , Mehrabani Mitra , Banazadeh Nabi , Dabaghzadeh Fatemeh , Shahabi Farzad 
Published: November 2021

AbstractSchizophrenia, as a chronic and disabling mental disorder, causes a wide range of symptoms, including cognitive impairments, positive, negative, and mood symptoms. There are no effective treatments for cognitive symptoms. Black myrobalan (Terminalia chebula Retz.), a medicinal plant of the Combretaceae family, exerts antioxidant, antiacetylcholinesterase, and anti‐inflammatory effects. These effects can lessen the symptoms of schizophrenia. So, this study was conducted to evaluate black myrobalan's impact on cognitive impairments and negative/positive symptoms in patients with chronic schizophrenia. This was a randomized, double‐blind, placebo‐controlled clinical trial in which participants were divided into treatment and placebo groups. They received six 500 mg capsules of black myrobalan or placebo in two divided doses for 4 weeks. Patients' cognitive impairments, positive, negative, depression/anxiety, and excitement/activity symptoms were assessed using the Screen for Cognitive Impairments in Psychiatry (SCIP) and the relevant subscales of the Positive and Negative Syndrome Scale (PANSS) pretreatment and 4 weeks after treatment. Cognitive impairments (SCIP) (p value .004), negative symptoms (PANSS subscale) (p value .017), and excitement/activity (PANSS subscale) (p value .003) were significantly improved in the black myrobalan group compared with the control group after 4 weeks. No serious adverse effects were reported. Black myrobalan could improve cognitive impairments, negative and excitement/activity symptoms in chronic schizophrenic patients.
Homogenization and locality of landscape characteristics in the waterfront space based on geotagged photographs
Authors: Wang Fang , Luo Yedian , Liu Zhao 
Published: November 2021

AbstractThe urban landscape reveals the relationship between the natural evolution process and artificial intervention force in the watershed system and also represents the most direct reflection of man–land relationships in watersheds. However, the homogeneity of modern urban functions affects the expression of cultural atmospheres. As a result, quantitative and qualitative analyses of the landscape homogenization level are of great significance for considering local culture in landscape planning according to locality conditions. In this study, open geotagged photographs were assessed to determine the landscape changes and differences in the Yangtze River Basin and the spatial characteristics of locality elements in order to identify the relationship between landscape locality and urbanization. The results indicate that the landscape element level changes gradually downstream of the Yangtze River and with increasing distance from the river bank. The closer the city to the lower reaches of the Yangtze River, the less dominant the main landscape element of the city. Several landscape elements were significantly agglomerated in space, and this agglomeration distribution was attributed to the degree of urbanization.