bluuebunny/crossref_metadata_2025_split huggingface dataset:
OS MINICURSOS DO PET GEOGRAFIA COMO EIXO AUXILIADOR NA GRADUAÇÃO EM GEOGRAFIA
Authors: Dozena Alessandro , Rosimeire Pinheiro Maia Antonia , Silva Arruda Miranda Marcellus , Geová Maia de Brito Anderson , De Lima Garcia Medeiros Breno , Silveira Felix Felipe , Johnatan Weverton da Silva José , Fonseca do Nascimento Jucielma , Gomes Soares Larícia , Tomaz da Silva Lígia , Alves Fernandes Nilvan , Dos Santos Trajano Tárcis , Rafaela Gonçalves da Silva Tatiane , Emanuella Rodrigues de Freitas Cruz Dara 
Published: December 2021

Os minicursos são atividades de extensão desenvolvidas pelo Programa de Educação Tutorial (PET) do curso de graduação em Geografia da Universidade Federal do Rio Grande do Norte (UFRN). A realização desta atividade surge das necessidades por parte dos graduandos em melhor absorverem determinados assuntos ligados à ciência geográfica. O PET Geografia ao visualizar essa necessidade dos graduandos, juntamente com as vivências da sala de aula dos próprios bolsistas do programa, instituiu a atividade denominada “minicurso” em seus planejamentos anuais, e vem ao longo dos anos realizando edições com várias temáticas como: Geoprocessamento para Iniciantes, Relatórios Ambientais, Normalização do Trabalho Científico entre tantas outras áreas de atuação do profissional geógrafo. Essa atividade está pautada na filosofia de atuação do programa - pesquisa, ensino e extensão, juntamente com os princípios da educação continuada. O presente trabalho teve por objetivo demonstrar como essa atividade de extensão auxilia na graduação de Geografia da UFRN, para isso foram selecionados os minicursos que ocorreram dos anos 2014 à 2017, o que totaliza 12 minicursos ao longo dos quatro anos de análise. Os resultados obtidos são frutos de questionários aplicados pelos ministrantes das atividades, as respostas destes questionários foram tabuladas e posteriormente analisadas.
Curso de Graduação em Biblioteconomia da UFRN: proposta metodológica para sua reformulação
Authors: Barbosa Neto Pedro Alves , Carvalho Luciana Moreira , Cunha Jacqueline de Araújo 
Published: December 2021

No presente trabalho objetivou-se, de forma geral, descrever os processos reflexivos empreendidos pelo Núcleo Docente Estruturante (NDE) do Curso de Biblioteconomia da Universidade Federal do Rio Grande do Norte, acerca da reformulação do Projeto Pedagógico do Curso (PPC), especificamente sobre a estrutura curricular. Como suporte para as reflexões foi feito um resgate histórico da formação do Bibliotecário no Brasil, a partir da análise descritiva das estruturas curriculares adotadas em cada contexto histórico social, vinculando-o as suas inspirações teóricas e identitárias. Em continuidade foi discutida a formação dos currículos mínimos (1962 e 1982) para os Cursos de Biblioteconomia, e a posterior migração da perspectiva dos conteúdos para as competências e habilidades emanadas pelas Diretrizes Curriculares Nacionais (DCN). Finalmente, é apresentada a proposta de metodologia utilizada para reformular a estrutura curricular do Curso de Biblioteconomia da UFRN, a luz das reflexões acerca das DCN .
Truncated Lactoferricin Peptide Controls Cervical Cancer Cell
Proliferation via lncRNA-NKILA/NF-κB Feedback Loop
Authors: Pan Yuan , Jiang Yuting , Cui Yingli , Zhu Jihong , Yu Yang 
Published: December 2021

Background:
Lactoferricin peptide (LP) has been reported to control cancer cell proliferation.
NF-κB interacting lncRNA (NKILA) is a tumor suppressor in several cancers.

Objective:
We aimed to explore the potential function of the truncated LP (TLP) in the prevention
of cervical cancer cell proliferation.

Methods:
Bioinformatics analysis via PPA-Pred2 showed that 18-aa N-terminus of truncated lactoferricin
peptide (TLP18, FKCRRWQWRMKKLGAPSI) shows higher affinity with nuclear factor
kappaB (NF-κB) than LP. The effects of LP and TLP18 on cervical cancer cells SiHa and HeLa
and the related mechanisms were explored by investigating NF-κB and lncRNA-NKILA.

Results:
TLP18 shows an inhibitory rate up to 0.4-fold higher than LP on the growth of cervical
cancer cells (P<0.05). NKILA siRNA promoted cell growth whether LP or TLP18 treatment
(P<0.05). TLP18 treatment increases the level of lncRNA-NKILA and reduces the level of NF-κB
up to 0.2-fold and 0.6-fold higher than LP (P<0.05), respectively. NKILA siRNA increased the levels
of NF-κB, cleaved caspase-3, and BAX (P<0.05). TLP18 increased apoptotic cell rate up to
0.2-fold higher than LP, while NKILA siRNA inhibited cell apoptosis cell growth even LP or
TLP18 treatment.

Conclusion:
Truncated Lactoferricin peptide controls cervical cancer cell proliferation via lncRNA-
NKILA/NF-κB feedback loop.
PAX5 Haploinsufficiency Induces Low T Cell Infiltration in the
Cancer Microenvironment via Reduced Chemokines
Authors: Wang Lei , Liang Xue , Liang Mi , Li Dang , Gu Jia , Huang Wei , Zhou Jianfeng 
Published: December 2021

Aims:
To investigate the effects of PAXT mutations on tumor immunity.

Background:
Loss of function of PAX5 plays a key role in the PAX5 mutation tumor.

Objective:
PAX5 haploinsufficiency promoting tumorigenesis is related to immune
escape, but there was no report about mechanisms of PAX5 mutation inducing tumor
immunological escape.

Method:
We constructed the PAX5 haplodeletion A20 cell lines using gene-editing
technology, built allografted A20 tumor models and evaluated the effect of PAX5
haplodeletion on T cells and chemokines in the tumor microenvironment (TME).

Result:
Our results from different methods indicated percentages of CD3+ CD4+ T
cells and CD3+ CD8+ T cells in TME of PAX5 haplodeletion clones decreased
significantly compared with that of PAX5 wild type control. Several chemokines, such as
Ccl2, Ccl4, Cxcl9 and Cxcl10, in TME of PAX5.

Conclusion:
Our study showed that PAX5 haploinsufficiency induced low T cell
infiltration in TME using decreased chemokines.
Review of Corticosteroid Use in Pediatric Cataract Surgery
Authors: Yulia Dian E. , Pambudy Indra M. , Amanda Lia 
Published: December 2021

Introduction:
Following pediatric cataract surgery, an intense inflammatory response is related to various complications, including posterior capsule opacification (PCO), which is a visually threatening incidence that can lead to visual axis opacification (VAO). Although corticosteroids are essentially effective in reducing inflammation, potential ocular side effects are a remaining concern.

Objective:
This study aimed to review the efficacy and safety of corticosteroid drugs and their administration routes in pediatric patients who underwent cataract surgery

Methods:
A literature search was conducted from four electronic databases using keywords selected a priori. Identified articles were sorted according to the type of corticosteroid used, route of administration, and outcome measures, including inflammatory response and ocular side effects.

Results:
Five studies were included with one case series, one retrospective case-control, and three clinical trials. The total number of subjects was 311 patients, with an age range of six weeks to 15 years old. Four studies analyzed the use of triamcinolone acetonide intracamerally, which was superior to topical steroids. Most of the studies reported a decrease in inflammatory parameters. The outcome of PCO and VAO varied between studies. Nearly all the studies observed elevated intraocular pressure (IOP) as an ocular side effect.

Conclusion:
Various corticosteroids and different delivery routes can be used to ameliorate inflammation in pediatric cataract surgery. However, there is promising evidence suggesting intracameral steroids as substantially beneficial in reducing inflammatory parameters. Due to the limited number of studies reviewed, no firm conclusion regarding the superior steroid preparation or route of administration can be inferred. This review highlights the need for further studies.
Nocardia Endophthalmitis- Prophylactic Prevention with an Innovative Approach
Authors: Kamath Atul , Pai Aditi , Reddy Jagadeesh K. 
Published: December 2021

Background:
Nocardia is a common cause of endophthalmitis in southern India. It is an aggressive disease with a poor prognosis.

Objective:
This study was conducted using an amikacin antibiotic in the drip irrigation of balanced saline solution (BSS) during the surgery to prophylactically study the occurrence of Nocardia endophthalmitis and any subsequent toxic effects of the antibiotics used.

Methods:
Prospective study period was of 6 months, starting from July to December-2018. Preoperative and postoperative specular counts and macular thickness using Ocular Coherence Tomography (OCT) were compared with any incidence of Nocardia endophthalmitis. A total of 500 patients operated for manual SICS were randomly assigned into 2 groups. The first group of 250 patients received antibiotic amikacin added to the Balanced Saline Solution (BSS) irrigating solution throughout the course of the surgery. The second control group received no antibiotics. Manual SICS was performed on all 500 patients by a single surgeon and was found to be uneventful. Pre- and postoperative corneal endothelial cell density and mean macular thickness using OCT were taken and recorded of all the patients, respectively, and data obtained were statistically compared.

Results:
No incidence of Nocardia endophthalmitis among the cataract surgeries operated was found. There was no drug-related toxicity to the cornea or macula. Furthermore, no incidence of Nocardia endophthalmitis has been reported since 2018 after using antibiotics.

Conclusion:
A simple routine of adding amikacin in the drip prophylactically during the course of surgery helped us prevent Nocardia endophthalmitis with no side effects. Also, it will be an innovative technique that is economically feasible and effective in regions where Nocardia endophthalmitis is prevalent.
The Standardization of Hospital-Acquired Infection Rates Using Prediction Models in Iran: Observational Study of National Nosocomial Infection Registry Data
Authors: Izadi Neda , Etemad Koorosh , Mehrabi Yadollah , Eshrati Babak , Hashemi Nazari Seyed Saeed 
Published: December 2021

Background
Many factors contribute to the spreading of hospital-acquired infections (HAIs).

Objective
This study aimed to standardize the HAI rate using prediction models in Iran based on the National Healthcare Safety Network (NHSN) method.

Methods
In this study, the Iranian nosocomial infections surveillance system (INIS) was used to gather data on patients with HAIs (126,314 infections). In addition, the hospital statistics and information system (AVAB) was used to collect data on hospital characteristics. First, well-performing hospitals, including 357 hospitals from all over the country, were selected. Data were randomly split into training (70%) and testing (30%) sets. Finally, the standardized infection ratio (SIR) and the corrected SIR were calculated for the HAIs.

Results
The mean age of the 100,110 patients with an HAI was 40.02 (SD 23.56) years. The corrected SIRs based on the observed and predicted infections for respiratory tract infections (RTIs), urinary tract infections (UTIs), surgical site infections (SSIs), and bloodstream infections (BSIs) were 0.03 (95% CI 0-0.09), 1.02 (95% CI 0.95-1.09), 0.93 (95% CI 0.85-1.007), and 0.91 (95% CI 0.54-1.28), respectively. Moreover, the corrected SIRs for RTIs in the infectious disease, burn, obstetrics and gynecology, and internal medicine wards; UTIs in the burn, infectious disease, internal medicine, and intensive care unit wards; SSIs in the burn and infectious disease wards; and BSIs in most wards were >1, indicating that more HAIs were observed than expected.

Conclusions
The results of this study can help to promote preventive measures based on scientific evidence. They can also lead to the continuous improvement of the monitoring system by collecting and systematically analyzing data on HAIs and encourage the hospitals to better control their infection rates by establishing a benchmarking system.
APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19
Authors: Larsen Christopher P. , Wickman Terrance J. , Braga Juarez R. , Matute-Trochez Luis A. , Hasty Anna E. , Buckner Lyndsey R. , Arthur John M. , Haun Randy S. , Velez Juan Carlos Q. 
Published: December 2021

Background and objectives
Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the APOL1 are responsible for a portion of this higher risk. We sought to assess the odds of AKI conferred by APOL1 risk alleles in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design, setting, participants, & measurements
Black Americans who tested positive for coronavirus disease 2019 (COVID-19) were genotyped to determine APOL1 risk allele status. We assessed the incidence of AKI, persistent AKI, and AKI requiring KRT within 21 days of the PCR-based diagnosis. Outcomes were adjusted for age, sex, body mass index, hypertension, eGFR, and use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker.

Results
In total, 126 cases of SARS-CoV-2 infection were included within a 5-month period, with 16 (13%) and 110 (87%) cases with two and zero/one APOL1 high-risk alleles, respectively. AKI occurred in 11 (69%) patients with two APOL1 high-risk alleles and 39 (35%) patients with zero/one high-risk alleles (adjusted odds ratio, 4.41; 95% confidence interval, 1.11 to 17.52; P=0.04). Persistent AKI occurred in eight (50%) patients with two APOL1 high-risk alleles and 21 (19%) of those with zero/one high-risk alleles (adjusted odds ratio, 3.53; 95% confidence interval, 1.8 to 11.57; P=0.04). AKI KRT occurred in four (25%) of those with two APOL1 high-risk alleles and eight (7%) of those with zero/one high-risk alleles (adjusted odds ratio, 4.99; 95% confidence interval, 1.02 to 24.4, P=0.05).

Conclusions

APOL1 high-risk alleles are associated with greater odds of AKI in Black American patients with COVID-19.
Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort
Authors: Herzog Katharina , Andersson Tomas , Grill Valdemar , Hammar Niklas , Malmström Håkan , Talbäck Mats , Walldius Göran , Carlsson Sofia 
Published: December 2021

OBJECTIVE
Type 1 diabetes is described to have an acute onset, but autoantibodies can appear several years preceding diagnosis. This suggests a long preclinical phase, which may also include metabolic parameters. Here we assessed whether elevations in glycemic, lipid, and other metabolic biomarkers were associated with future type 1 diabetes risk in adults.

RESEARCH DESIGN AND METHODS
We studied 591,239 individuals from the Swedish AMORIS cohort followed from 1985–1996 to 2012. Through linkage to national patient, diabetes, and prescription registers, we identified incident type 1 diabetes. Using Cox regression models, we estimated hazard ratios for biomarkers at baseline and incident type 1 diabetes. We additionally assessed trajectories of biomarkers during the 25 years before type 1 diabetes diagnosis in a nested case-control design.

RESULTS
We identified 1,122 type 1 diabetes cases during follow-up (average age of patient at diagnosis: 53.3 years). The biomarkers glucose, fructosamine, triglycerides, the ratio of apolipoprotein (apo)B to apoA-I, uric acid, alkaline phosphatase, and BMI were positively associated with type 1 diabetes risk. Higher apoA-I was associated with lower type 1 diabetes incidence. Already 15 years before diagnosis, type 1 diabetes cases had higher mean glucose, fructosamine, triglycerides, and uric acid levels compared with control subjects.

CONCLUSIONS
Alterations in biomarker levels related to glycemia, lipid metabolism, and inflammation are associated with clinically diagnosed type 1 diabetes risk, and these may be elevated many years preceding diagnosis.
Tingkat Kondisi Fisik Atlet Wushu Kategori Taolu Chang Quan
Authors: Azra Melta Faulia , Masrun Masrun , Suwirman Suwirman , Ridwan M 
Published: December 2021

Masalah dalam penelitian ini yaitu belum baiknya kondisi fisik yang dimiliki atlet. Tujuan dari penelitian ini adalah melihat bagaimana Tingkat Kondisi Fisik Atlet Wushu Kategori Taolu Chang Quan Kabupaten Solok. Jenis penelitian ini kuantitatif dengan mengunakan metode deskriptif. Populasi dalam penelitian ini berjumlah 23 orang. Teknik pengambilan sampel menggunakan purposive sampling, dengan demikian jumlah sampel di dalam penelitian adalah berjumlah 23 orang atlet Wushu Kategori Taolu Chang Quan Kabupaten Solok. Teknik analisis data adalah presentase. Hasil penelitian: (1) Daya tahan aerobic pada kategori baik sekali dengan rata-rata 37,5ml/kg.bb/m atau sekitar 12,83%, (2) Kekuatan otot lengan yang dimiliki pada kategori kurang sekali dengan rata-rata 25 atau sekitar 39%, (3) Kecepatan yang dimiliki pada kategori kurang sekali rata-rata 11,44% atau -59, (4) Kelentukan yang dimiliki pada kategori kurang sekali dengan rata-rata 46,27% atau sekitar 30%, (5) Kelincahan yang dimiliki pada kategori cukup dengan rata-rata 15 atau sekitar 30,00%, (6) Keseimbangan yang dimiliki pada kategori kurang rata-rata 60 detik atau sekitar 53,61%, dengan demikian dapat disimpulkan bahwa, kondisi fisik yang dimiliki atlet wushu kategori taolu chang quan baik dari indikator, daya tahan, kekuatan, kecepatan, kelincahan, kelentukan, dan keseimbangan, masih berada pada kategori kurang dan perlu ditingkatkan untuk menjadi lebih tinggi.
Tingkat Kepercayaan Diri dan Kecemasan Atlet PPLP Jawa Barat selama Menjalani Training From Home (TFH) pada Masa Adaptasi Kebiasaan Baru (AKB)
Authors: Purnamasari Ira , Novian Geraldi 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui tingkat kepercayaan diri dan kecemasan atlet PPLP Jawa Barat selama menjalani Training From Home (TFH) pada masa Adaptasi Kebiasaan Baru (AKB). Metode penelitian yang digunakan adalah metode deskriptif kuantitatif dengan correlational design. Subjek dalam penelitian ini adalah 32 atlet PPLP Jawa Barat yang terdiri dari 9 cabang olahraga dengan usia 16,218 ± 1,099 tahun yang diambil menggunakan simple random sampling dari populasi. Instrumen penelitian yang digunakan berupa kuesioner kepercayaan diri dan Sport Anxiety Scale-2 (SAS-2). Pengisian kuesioner mengunakan skala Likert dan didistribusikan satu kali kepada subjek dengan menggunakan media Google Form pada bulan Maret 2021. Analisis data menggunakan SPSS versi 24 dengan melakukan deskripsi statistik, uji normalitas, uji korelasi dan persentase hasil. Berdasarkan hasil studi, maka dapat disimpulkan bahwa terdapat hubungan yang signifikan antara tingkat kepercayaan diri dan kecemasan atlet PPLP Jawa Barat selama menjalani TFH pada masa AKB. Atlet PPLP Jawa Barat memiliki tingkat kepercayaan diri yang tinggi (61%) dan tingkat kecemasan yang rendah (38%). Penulis menyarankan untuk lebih memperhatikan aspek psikologis dan jangan hanya berfokus pada aspek fisiologis atlet, terlebih pada situasi dan kondisi saat ini. Penulis menyarankan agar program latihan mental dapat diintegrasikan dalam periodisasi program latihan yang telah disusun.
Minat Peserta Didik Kelas XI terhadap Proses Pembelajaran Renang
Authors: Ramadhan Syifa Fahmi , Lesmana Heru Syarli , Sin Tjung Hauw , Denay Naluri 
Published: December 2021

Olahraga renang dalam proses pendidikan diartikan sebagai upaya yang diberikan pada peserta didik untuk mengembangkan potensi yang dimiliki peserta didik. Permasalahan yang terdapat pada penelitian ini adalah rendahnya minat peserta didik kelas XI di SMA Negeri 7 Padang dalam kegiatan pembelajaran olahraga renang. Tujuan dari penelitian ini untuk melihat seberapa minat dari setiap peserta didik dalam pembeajaran olahraga renang. Jenis penelitian yang digunakan adalah penelitian deskriptif. Penelitian ini dilaksanakan di SMA Negeri 7 Padang pada bulan Agustus dan September 2020. Jumlah populasi adalah 324 orang pada tahun ajaran 2020/2021. Teknik pengambilan data yang digunakan ialah teknik simple random sampling. Sampel dalam penelitian ini berjumlah 65 orang peserta didik yang dijadikan sampel dari setiap kelas XI IPA dan IPS. Instrumen pengambilan data dilakukan melalui pembagian angket pada peserta didik. Hasil penelitian menunjukkan minat peserta didik dalam pembelajaran olahraga renang termasuk di klasifikasi “kuat/baik” (78,20%). Hal ini sejalan dengan hasil wawancara dimana peserta didik memiliki minat yang tinggi terhadap pembelajaran renang. Namun nilai yang didapatkan masih berada dibawah KKM dikarenakan beberapa faktor seperti kurangnya pemahaman peserta didik terhadap materi dan kurang tepatnya metode pembelajaran yang digunakan guru pada proses pembelajaran. Olah karena itu, dalam penelitian ini diharapkan proses pembelajaran dapat meningkat minat dari peserta didik dalam belajar olahraga renang.
Pengaruh Senam Aerobik terhadap Peningkatan Vo2max pada Peserta Sanggar Senam Studio Nachatib di Masa New Normal
Authors: Hasibuan Silvia Sri Hartati , Fardi Adnan , Pitnawati Pitnawati , Soniawan Vega 
Published: December 2021

Masalah dalam penelitian ini adalah rendahnya kemampuan Vo2max peserta sanggar senam studio nachatib. Tujuan penelitian ini untuk mengtahui seberapa besar pengaruh latihan senam aerobik terhadap peningkatan Vo2max pada peserta sanggar senam studio nachatib. Penelitian ini adalah praeksperimen.Teknik pengambilan sampel menggunakan teknik purposive sampling, teknik pengambilan sampel tidak brdasarkan random, daerah atau strata, melainkan dengan adanya pertimbangan yang terfokus pada tujuan tertentu, maka jumlah sampel dalam penelitan adalah 5 orang peserta dengan ketentuan usia 19-20 dan 21-30 tahun. Instrument pada penelitian ini adalah menggunakan bleeptest dan teknik analisis data menggunakan uji t dependend sampel melalui uji persyaratan.Berdasarkan analisis data dalam penelitian ini menggunakan uji t, hasil ini dibuktikan dengan perbandingan hasil hitung rata–rata pada uji t kelompok pretest dan posttest (25,16< 27, 56) nilai thitung3, 87 >ttabel 2,13. Dan terdapat peningkatan hasil kemampuan antara pretest dan posttestsebesar 2,40, artinya penerapan latihan senam aerobik memberikan pengaruh terhadap peningkatan Vo2max pada peserta sanggar senam studio nachatib di masanew normal.
Философия взаимодействия. Доклад
Authors: Ситников Антон 
Published: December 2021

В предлагаемой философской концепции представление о взаимодействии принимается в качестве исходной идеальной конструкции, из которой последовательно выводятся понятия о материи, пространстве, времени и других предметах философского внимания.
Построение философии взаимодействия производится с помощью метода взаимодействий, возникающего одновременно с созданием самой философии.
Назначение новой философии – решение существующих социальных проблем.
Концептуальное проектирование информационной системы прогнозирования демографических показателей региона
Authors: Будаев Евгений 
Published: December 2021

Развитие информационных технологий диктует создание информационных систем в различных отраслях экономики. Создание демографической системы, как и создание любой предметной системы имеет свою специфику, которая связана со способами добычи, хранения и обработки демографической информации. В статье рассматриваются основные моменты концептуального проектирования информационной системы прогнозирования демографических показателей региона.
Ключевые слова: Информационная система, проектирование информационных систем, прогнозирование данных, демография, региональная информационная система.
Series Solutions of Delay Integral Equations via a Modified Approach of Homotopy Analysis Method
Authors: Huseen Shaheed N. , Tayih Ali S. 
Published: December 2021

In this paper, the series solutions of a non-linear delay integral equations are considered by a modified approach of homotopy analysis method (MAHAM). We split the function into infinite sums. The outcomes of the illustrated examples are included to confirm the accuracy and efficiency of the MAHAM. The exact solution can be obtained using special values of the convergence parameter.