bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features of Infantile GM1 Gangliosidosis: Report of an Iranian Patient
Authors: Ordooei Mahtab , Fallah Razieh , Abdi Fatemeh , Soheilipour Fahimeh 
Published: January 2021

Background: GM1 gangliosidosis is an autosomal recessive lysosomal storage disease due to a lack of β-galactosidase activity, exactly because of mutations in the GLB1 gene. GM1 gangliosidosis is a rare disease that could occur either during infancy (infantile type 1), as a juvenile (type 2), or in adulthood (type 3) in both nervous and skeletal systems. Type 1 is characterized by premature psychomotor deterioration, visceromegaly, macular cherry-red spot, skeletal deformities, and death in the first 2 years of life.
Case Presentation: We reported an Iranian infant who, on initial check-up, had coarse face, visceromegaly, dystonia, and hepatosplenomegaly that increased at 15 months of age. At the initial check-up, a genetic test was performed and GM1 gangliosidosis type 1 was diagnosed.
Conclusion: infant form is characterized by early-onset before the age of 6 months and rapidly progressive psychomotor deterioration, facial abnormalities, and visceromegaly.
Przedawnienia zobowiązań podatkowych
Authors: Janas Dominika 
Published: January 2021

Przedawnienie zobowiązań podatkowych jest nieefektywną formą wygaśnięcia zobowiązania podatkowego. W artykule poruszone zostały kwestie zobowiązania oraz przedawnienia i jego terminów, a także rozróżniono pojęcia zawieszenia i przerwy biegu terminu przedawnienia. Zaprezentowano skutki, a co więcej dane obrazujące wielkość zaległości podatkowych w Polsce w latach 2014–2017. Konsekwencją przedawnienia jest brak możliwości pobrania zapłaty przez organ podatkowy i powstawanie zaległości podatkowych negatywnie wpływających na budżet państwa.
Nadzór nad rynkiem finansowym w Polsce a ochrona konsumenta
Authors: Kudlak Izabela 
Published: January 2021

Celem niniejszego artykułu jest analiza nadzoru nad rynkiem finansowym w Polsce, porównanie możliwych koncepcji oraz odniesienie ich do ochrony konsumenta. Autor postanowił za pomocą przeglądu literatury i aktów prawnych przeanalizować stwierdzenie, że nadzór nad rynkiem finansowym w Polsce jest koncepcją odpowiednią, nie wymagającą zmian, która zapewnia konsumentom odpowiednią ochronę.
Eduardo C.B. BITTAR, Introdução ao estudo do direito: humanismo, democracia e justiça
Authors: Zezza Michelle 
Published: January 2021

Este artículo reseña: Eduardo C.B. BITTAR,Introdução ao Estudo do Direito: humanismo, democracia e justiça,Saraiva, 2a ed., São Paulo, 2019, 616 pp.
Extensão do PMV para avaliação do conforto térmico de idosas em ambientes com ventilação natural
Authors: Ruviaro Raiana Spat , Zambonato Bruna , Grigoletti Giane de Campos 
Published: January 2021

O envelhecimento populacional torna necessário criar condições para que idosos vivam com qualidade de vida. O conforto térmico das edificações é fundamental para atingir essa meta. Esta pesquisa analisou a aplicabilidade do Voto Médio Estimado (PMV) e a sua extensão (PMVe) para avaliação do conforto térmico de idosas, com idade igual ou superior a 60 anos. O estudo foi aplicado em dois residenciais geriátricos naturalmente ventilados localizados em Santa Maria, RS, região de clima temperado com verão quente. As variáveis ambientais temperatura do ar, umidade relativa do ar, temperatura de globo e velocidade do ar foram medidas e foram aplicados questionários para o levantamento da sensação e preferência térmicas das idosas e das variáveis vestimenta e atividade metabólica. Então, calculou-se o índice de sensação de conforto. A sensação térmica real dos usuários foi comparada com o PMV e o PMVe, com fatores de correção de 0,5, 0,7 e 0,9. Comparando os três valores de PMVe, estimou-se que, quanto menor o fator expectativa, menor é a diferença entre PMVe e sensação térmica para valores negativos (frio). O PMVe com fator de correção 0,5 apresentou perfeita correlação das variáveis PMV e sensação térmica relatada em 11,54% das medições, já o PMVe de 0,7 e de 0,9 não apresentaram nenhum ponto sobre a reta de referência. O estudo mostrou que a extensão do PMV não corrige as imprecisões do modelo, mas reduz as diferenças encontradas com os valores de sensação térmica relatada, diminuindo a superestimação da sensação de frio que o PMV resultava para as idosas.
Regional Regulation Implementation of Madiun City Number 45 of 2018 Concerning with Prevention and Enhancement of Slum Housing and Settlement Quality
Authors: Sarjiyati Sarjiyati , Nugroho Sigit Sapto , Pratiwi Anggun Enggar 
Published: January 2021

<table width="680" border="1" cellspacing="0" cellpadding="0" align="left"><tbody><tr><td valign="top" width="487"><p><strong>The purpose of this study was to determine and analyze the implementation of the Regional Regulation of Madiun City Number 45 of 2018 concerning with Prevention and Improvement of Quality of Housing and Slums and the constraints in the implementation of the City without Slums Program in Madiun City. This research method uses empirical data that is obtained directly through field research with primary, secondary and tertiary data sources as well as data collection by observation, interview, document study analyzed descriptive qualitative. The results of this study indicate that the Government of Madiun City has implemented Regional Regulation Number 45 of 2018 regarding Prevention and Improvement of Quality of Housing and Slums, quite well, there are 6 (six) villages which are categorized in mild slum areas. There are inertnal and external constraints in the implementation of the Cityless Slums Program in Madiun City.</strong><strong></strong></p><p><strong> </strong></p></td></tr></tbody></table>
The Problems of Controlling the Transparency of the Financial Budget Use of Corona Virus 19
Authors: Karjoko Lego , Handayani I Gusti Ayu Ketut Rachmi , Jaelani Abdul Kadir 
Published: January 2021

<table width="680" border="1" cellspacing="0" cellpadding="0" align="left"><tbody><tr><td valign="top" width="487"><p><strong>This study aims to analyze and illustrate the problem of monitoring the transparency of the use of the Corona Virus 19 financial budget. Transparency is one of the important elements in the realization of good governance. This research is a normative study with a statutory approach. The data of this research uses secondary data with primary, secondary and tertiary legal materials. The results show that first, the Covid-19 pandemic has caused a decline in the economy and activities in various sectors. Second, supervision of the use of covid funds is very weak considering Law Number 2 of 2020 gives absolute power to change budget postors and remove checks and balances and gives immunity authority to the government in managing state finances so that they cannot be corrected and are immune to the law.</strong><strong></strong></p><p><strong> </strong></p><p><strong> </strong></p><p><strong> </strong></p></td></tr></tbody></table>
Addressing Supply Chain Management Issues in Cost-effective Maternal and Pediatric Global Surgery: A Call to Action
Authors: Navarro Sergio M. , Sibiya Andile , Nourian Maziar M. , Stewart Kelsey A. , Ottesen Taylor D. , Price Raymond R. 
Published: January 2021

Persistent global disparities in maternal and neonatal outcomes exist, in part, due to a lack of access to safe surgery. This commentary examines the relative need for increased focus on access to safe maternal and pediatric surgery globally, starting with a focus on cost-effective surgeries. There is a need to understand context-specific surgeries for regions, including understanding regional versus tertiary development. Most important is a need to understand the crucial role of supply chain management (SCM) in developing better access to maternal and pediatric surgery in limited resource settings. We evaluate the role of SCM in global surgery and global health, and the current landscape of inefficiency. We outline specific findings and takeaways from recent solutions developed in pediatric and maternal surgery to address SCM inefficiencies. We then examine the applicability to other settings and look at the future. Our goal is to summarize the challenges that exist today in a global setting to provide better access to maternal and pediatric surgery and outline solutions relying on structural, SCM-related framework.
Key words: • Pediatric surgery • Neonatal outcomes • Supply-chain management • Limited resource settings

Copyright © 2020 Navarro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Survival Analysis of Stage II Gastric Cancer Patients after D2 Gastrectomy: A Chinese People-based Research Running Head: Survival of Stage II Gastric Cancer
Authors: Deng Zi-Jian , Nie Run-Cong , Lu Jun , Chen Xi-Jie , Xiang Jun , Huang Chang-ming , Chen Ying-bo , Peng Jun-Sheng , Chen Shi 
Published: January 2021

Abstract
Objective: The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients.Methods: We retrospectively reviewed 1121 stage II gastric cancer patients who underwent D2 radical gastrectomy from 2007-2017 in the Sixth Affiliated Hospital of Sun Yat-sen University, FuJian Medical School Affiliated Union Hospital and Sun Yat-sen University Cancer Center. Propensity score matching (PSM) was used to ensure that the baseline data were balanced between the adjuvant chemotherapy (AC) group and surgery-only group. Kaplan-Meier survival and multivariate Cox regression analyses were carried out to identify independent prognostic factors. Results: In univariate analysis, after propensity score matching, age, tumor location, tumor size, CEA, T stage and N stage were associated with overall survival (OS). Multivariate analysis illustrated that age ≥60 years old, linitis plastica and T4 were independent risk factors for OS, but lower location and adjuvant chemotherapy were protective factors. Conclusion: Adjuvant chemotherapy is helpful for stage II gastric cancer patients. These prognostic factors can help guide individual therapy.
BoostTree and BoostForest for Ensemble Learning
Authors: Zhao Changming , Wu Dongrui , Huang Jian , Yuan Ye , Zhang Hai-Tao , Peng Ruimin , Shi Zhenhua , Guo Chenfeng 
Published: January 2021

Abstract
Bootstrap aggregating (Bagging) and boosting are two popular ensemble learning approaches, which combine multiple base learners to generate a composite model for more accurate and more reliable performance. They have been widely used in biology, engineering, healthcare, etc. This article proposes BoostForest, which is an ensemble learning approach using BoostTree as base learners and can be used for both classification and regression. BoostTree constructs a tree model by gradient boosting. It achieves high randomness (diversity) by sampling its parameters randomly from a parameter pool, and selecting a subset of features randomly at node splitting. BoostForest further increases the randomness by bootstrapping the training data in constructing different BoostTrees. BoostForest outperformed four classical ensemble learning approaches (Random Forest, Extra-Trees, XGBoost and LightGBM) on 34 classification and regression datasets. Remarkably, BoostForest has only one hyper-parameter (the number of BoostTrees), which can be easily specified. Our code is publicly available, and the proposed ensemble learning framework can also be used to combine many other base learners.
Clinical Characteristics of Pregnant Women With COVID-19 In Japan: A Nationwide Questionnaire Survey
Authors: Arakaki Tatsuya , Hasegawa Junichi , Sekizawa Akihiko , Ikeda Tomoaki , Ishiwata Isamu , Kinoshita Katsuyuki 
Published: January 2021

Abstract
Background: Few reports have presented an overall view of pregnant women with coronavirus disease 2019 (COVID-19) across an entire country and throughout the entire gestation period. Furthermore, no such reports are available for Japan. We examined the clinical characteristics and outcomes of pregnant women with COVID‑19 on a national scale in Japan.Methods: A nationwide questionnaire-based survey for all 2,185 maternity services in Japan was conducted between July and August 2020. Information regarding maternal characteristics and epidemiological, clinical, treatment, and perinatal outcomes of pregnant women diagnosed with COVID-19 between 16 January and 30 June 2020 were collected. Main outcome measures were incidence of pregnant women with COVID-19 and infant infection, positive rate of the universal screening test for asymptomatic pregnant women, identification of infection route and rates of maternal death, and severe cases.Results: Responses from 1,418 institutions were assessed (65% of all delivery institutions in Japan). Seventy-two pregnant women were reported to have been diagnosed with COVID-19. The positive rate of the universal screening test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among asymptomatic pregnant women was 0.03% (2/7428). The most common route of infection was familial (57%). Fifty-eight pregnant women with COVID-19 were symptomatic, of whom five (8.6%) had a severe infection and one died (a tourist). Severe respiratory symptoms, oxygen administration, and pneumonia were frequently reported in the third trimester and postpartum period compared with in early pregnancy (22.2% vs 2.5% [P=0.03], 38.9% vs 7.5% [P=0.01], and 50.0% vs 7.5% [P<0.01], respectively). All pregnant women with COVID-19 underwent caesarean sections, regardless of symptoms. There were no SARS-CoV-2 transmissions to newborns.Conclusions: In Japan, the number of cases of COVID-19 infection in pregnant women is very low. Compared with early pregnancy, late pregnancy may be a risk factor for exacerbation of symptoms and familial transmission is the most common route of infection. The importance of infection prevention should be emphasised, especially in women in late pregnancy, their families, and any cohabitants.Trial registration: None
Mental health in COVID-19 survivors from a general hospital: association with sociodemographic, clinical, and inflammatory variables
Authors: Huarcaya-Victoria Jeff , Barreto Jesica , Aire Lucia , Podestá Angela , Caqui Mónica , Guija-Igreda Rosa , Castillo Claudia , Alarcon-Ruiz Christoper A. 
Published: January 2021

Abstract
Background: The current COVID-19 (coronavirus disease 2019) pandemic constitutes a significant problem for the world's public health and generates mental health problems.Objective: To describe the characteristics of mental health in survivors of COVID-19 and the main sociodemographic, clinical, and immune factors related.Method: A Cross-sectional and correlational study was conducted on 318 patients (196 women, mean age 54.4 ± 15.1 years) surviving COVID-19 from one hospital in Peru in which sociodemographic, clinical, and immune characteristics were explored. Through telephone interviews, an evaluation of the presence of depressive, anxious, somatic, and distress symptoms was carried out using standardized scales. Adjusted prevalence ratios (PRa) were estimated.Results: A significant proportion of the patients have depressive (30.3%), anxious (29.9%), somatic (33.7%), and distress (28.7%) symptoms. In the regression analysis, the variables associated with a higher frequency of clinically relevant mental symptoms were female sex (depression: aPR = 2.29; anxiety: PRa = 2.71; somatic symptoms: PRa = 2.04; distress: PRa = 2.11), proceeding outside the capital (depression: PRa = 1.61; anxiety: PRa = 1.53), the self-perception of a greater severity of the infection (depression: PRa = 5.53; anxiety: PRa = 2.29; distress: PRa = 14.78), the presence of persistent COVID-19 symptoms (depression: PRa = 8.55; anxiety: PRa = 11.38; somatic symptoms: PRa = 5.46; distress: PRa = 20.55), a history of psychiatric treatment (depression: PRa = 2.29; somatic symptoms: PRa = 2.90 ; distress: PRa = 3.80), the history of a family member infected by COVID-19 (anxiety: PRa = 4.71; somatic symptoms: PRa = 1.99), and a neutrophil-lymphocyte index greater than 6.5 (depression: PRa = 1.67; anxiety: PRa = 1.82).Conclusion: COVID-19 survivors show a high prevalence of negative mental symptoms. Some useful variables have been found when identifying vulnerable patients requiring psychiatric care.
Analysis of 6−10-Year-Old Children Feet Anthropometric Sizes and Pes Planus, Pes Cavus Predisposition in Central Anatolia
Authors: Alsancak Serap , Güner Senem , Guven Enver , Özgün Ali , Akkaş Yunis , Alkış Neslihan 
Published: January 2021

Abstract
Background: Information on the foot structures of Central Anatolian children is limited. Foot structures of children aged 6−10 years were shown to be different according to sex and increasing age.Objective: This study aimed to compare the foot anthropometric values by age and sex and collect the foot anthropometric data to reveal the relationship between pes planus and pes cavus in the arches of children according to age.Methods: Footprints of 335 children (180 boys and 155 girls) aged 6−10 years were taken by the foot-print method and evaluated using 18 different parameters. To examine the relationship between the parameters, normality values were examined. Independent samples t-test was used to analyze sex differences in terms of foot size and shape.Results: Correlations between other parameters were determined using the correlations analysis method. TFL (Truncated foot length), metatarsal circumference, and foot length were strongly correlated with age in the children. Foot rotation increased with body mass index in the girls compared to that in the boys.Conclusions: Planning shoe production accordingly will contribute to the development of healthy feet in children. This article focused on foot structures of in Central Anatolia and to identify early foot deformities in children. This study found that the length of the TFL was smaller in boys than in girls.
The Benefits of Physical Activity on Indicators of Cardiovascular Risk in Community-Dwelling Older Adults with Hypertension in Korea: A Longitudinal Study
Authors: Ahn Jeong-Ah , Min Deulle 
Published: January 2021

Abstract
Purpose: The study aimed to explore the effects of physical activity on indicators for cardiovascular risk in a sample of community-dwelling older adults with hypertension.Methods: This longitudinal study used data collected from the Elderly Cohort Database of the National Health Insurance Service in South Korea between 2002 and 2013. Participants included 10,588 older adults (≥ 60 years) with hypertension. Data assessing self-reported physical activity, blood pressure, fasting blood glucose, body mass index, and total cholesterol levels throughout the 12-year study were extracted from the original database and analyzed. Participants were categorized into 4 groups based on the reported changes in physical activity over time; Group I (totally inactive), II (inactive to active), III (active to inactive), and IV (totally active). Cox proportional hazard model was used to confirm the risk of cardiovascular indicators over time in each group.Results: Participants’ mean age was 64.2 years in the initial year of 2002. The number of participants in Groups I, II, III, and IV was 4032, 2697, 1919, and 1940, respectively. Group IV showed a significant decline in risk for uncontrolled hypertension compared to Group I (HR = 0.87, 95% CI [0.800-0.948]). Group II showed a significant decrease in risk for uncontrolled diabetes compared to Group I (HR = 0.94, 95% CI [0.888-0.999]).Conclusions: Physical activity is an essential non-pharmacological and self-management intervention that can be easily implemented among older adults with hypertension. Healthcare providers should be aware of the importance of older adults’ physical activity and encourage them to perform and maintain it steadily for better long-term cardio-metabolic outcomes.
Migration of catheter of a totally implantable venous access port to right thoracic cavity in a child - a case report
Authors: Xu Qiteng , Ren Yueyi , Hu Yifei , Duan Shuhua , Chen Rui , Yuan Junhui 
Published: January 2021

Abstract
Background: The totally implantable venous access port (TIVAP) is a secure and practical choice for children undergoing long-term chemotherapy. Nevertheless, various complications still need to be treated cautiously. Among the complications, the migration of catheters to the thoracic cavity is a very rare (but potentially severe) condition that may necessitate device reimplantation. Furthermore, this migration may even be life-threatening if it is not detected in time.Case presentation: A 1-year-old girl undergoing palliative chemotherapy underwent TIVAP placement via the right internal jugular vein. During the operating procedure, the catheter tip was located in the right atrium, which was confirmed by the use of C-arm. Prophylactic intravenous antibiotics were then adopted with routine aspiration and with flushing being conducted each time before administration. Massive right pleural effusion and migration of the catheter tip to the right thoracic cavity were detected on the 2nd day after implantation, which resulted in the removal and reimplantation of the TIVAP device.Conclusions: The migration of the catheter into the thoracic cavity should be considered a possible complication of TIVAP implantation in children. Early detection and reimplantation may provide opportunities for the prevention of further severe complications.
Identifying new COVID-19 receptor Neuropilin-1 in severe Alzheimer’s diseases patients group brain using genome-wide association study approach
Authors: Lim Key-Hwan , Yang Sumin , Kim Sung-Hyun , Joo Jae-Yeol 
Published: January 2021

Abstract
Background Numerous studies have been conducted on different aspects of the COVID-19 (coronavirus disease 2019) pandemic, which is caused by SARS-CoV-2, since its emergence in late 2019. Mutual relations among SARS-CoV-2 and neuro-pathophysiological phenomena are continuously being demonstrated, and several underlying diseases, such as those in the elderly, are positively correlated with susceptibility to SARS-CoV-2 infection. The expression of angiotensin converting enzyme 2 (ACE2), which is required for SARS-CoV-2 infection, was recently demonstrated to be increased in Alzheimer’s disease (AD) patients.Methods Recent preclinical studies have shown that Neuropilin-1 (NRP1), which is a transmembrane protein with roles in neuronal development, axonal outgrowth, and angiogenesis, also plays a role in the infectivity of SARS-CoV-2. Thus, we hypothesized that NRP1 may be upregulated in AD patients and that a correlation between AD and SARS-CoV-2 NRP1-mediated infectivity may exist. We used an AD mouse model that mimics AD and performed high throughput total RNA-seq with brain tissue and whole blood. For quantification of NPR1 in AD, brain tissues and blood were subjected to western blotting and RT-qPCR analysis. In silico analysis for NRP1 expression in AD patients has been performed on the human hippocampus data sets (GSE4226, GSE1297).Results Many cases of severe symptom of COVID-19 are concentrated in elderly group who have complications such as diabetes, degenerative disease, and brain disorders. Total RNA-seq analysis showed that Nrp1 gene was commonly overexpressed in AD model. Similar to ACE2, NRP1 protein also strongly expressed in the AD brain tissues. Interestingly, in silico analysis revealed that the level of expression for NRP1 was distinct at age and AD progression.Conclusions Given that the NRP1 is highly expressed in AD, it will be important to understand and predict that NRP1 may a risk factor for SARS-CoV-2 infection in AD patients. This will support to development of potential therapeutic drug to reduce SARS-CoV-2 transmission.