bluuebunny/crossref_metadata_2025_split huggingface dataset:
AKTIVITAS ANTIHIPERKOLESTEROLEMIA EKSTRAK AKAR DAN BATANG KEMANGI HUTAN (Ocimum sanctum) PADA TIKUS PUTIH
Authors: Aloysius M. Kopon Yohana K. A. Mbulang, Agustine E. Amsik 
Published: July 2021

ABSTRACTHypercholesterolemia is a high level of cholesterol in the blood ≥ 200 mg/dl. Ocimum sanctum is medical plants which have antihypercholesterolemic effects. This study aims to determine that antihypercholesterolemic activity and the best dose of roots and stems extracts of Ocimum sanctum which can provide antihypercholesterolemic effects in white rats fed a high fat diet. A total of 25 rats divided into 5 groups that is group positive control, group negative control, group roots and stems extracts of Ocimum sanctum with dose of 50 mg/kg body weight, 75 mg/kg body weight and 100 mg/kg body weight. Cholesterol and triglyseride levels measurement using the CHOP- PAP and GPO-PAP methods. The results of statistical analysis showed that there was an antihypercholesterolemic effect from the three doses of root and stem extracts Ocimum sanctum. The best dose as an antihypercholesterolemia is dose III (100 mg/kg body weight). Keywords : Antihypercholesterol, total cholesterol, triglycerides. ABSTRAKHiperkolesterolemia merupakan tingginya kadar total kolesterol dalam darah ≥ 200 mg/dl. Kemangi hutan merupakan tanaman obat yang memiliki efek sebagai antihiperkolesterolemia. Penelitian ini bertujuan untuk mengetahui aktivitas antihiperkolesterolemia dan dosis yang paling baik dari ekstrak akar dan batang kemangi hutan yang dapat memberikan efek antihiperkolesterolemia pada tikus putih yang diberi pakan diet lemak tinggi. Sebanyak 25 ekor tikus dibagi 5 kelompok yaitu kelompok kontrol positif, kelompok kontrol negatif, kelompok ekstrak akar dan batang kemangi hutan dengan dosis 50 mg/kg BB, 75 mg/kg BB, dan 100 mg/kg BB. Kadar kolesterol dan trigliserida diukur menggunakan metode CHOD-PAP dan GPO-PAP. Hasil analisis statistik menunjukkan adanya efek antihiperkolesterolemia dari ketiga dosis ekstrak akar dan batang kemangi hutan. Dosis yang paling baik sebagai antihiperkolesterolemia adalah dosis III (100 mg/kg BB). Kata kunci : Antihiperkolesterolemia, kolesterol total, trigliserida.
POTENSI EKSTRAK ETANOL DAUN ANDONG MERAH (Cordyline fruticosa (L.) A. Cheval) SEBAGAI ANTIOKSIDAN PENANGKAL RADIKAL DPPH
Authors: Utami Yuri Pratiwi 
Published: July 2021

AbstractAndong leaf is one of the traditional medicinal plants that is proven to have various properties including as a (natural) medicinal ingredient. Andong plants contain several chemical compounds including saponins, tannins, flavonoids, polyphenols, steroids. The purpose of this study was to determine the potential of red andong leaf extract (Cordyline fruticosa (L.) A. Cheval) as a radical scavenging antioxidant for DPPH. In this study red andong leaves (Cordyline fruticosa (L.) A. Cheval) were extracted using maceration method with 70% ethanol as solvent. The results showed that anthocyanins were cyanidin. Antioxidant activity was measured by reducing DPPH free radicals with UV-Vis spectrophotometry at a wavelength of 517 nm. The results showed that red andong red leaf extract had strong antioxidant potential with an IC50 value of 64.5197 g/mL against free radicals DPPH and vitamin C as a comparison showed a very strong antioxidant potential with an IC50 value of 2.12 g/mL.Keywords : Andong leaf, antioxidant, DPPH AbstrakDaun andong merupakan salah satu tanaman obat tradisional yang terbukti memiliki berbagai khasiat diantaranya sebagai bahan obat (alami). Tanaman andong mengandung beberapa senyawa kimia diantaranya yaitu saponin, tanin, flavonoid, polifenol, Steroida. Tujuan dari penelitian ini adalah untuk mengetahui potensi ekstrak daun andong merah (Cordyline fruticosa (L.) A. Cheval) sebagai antioksidan penangkal radikal DPPH. Pada penelitian ini daun andong merah (Cordyline fruticosa (L.) A. Cheval) diekstraksi dengan menggunakan metode maserasi dengan pelarut etanol 70%. Hasil penelitian menunjukkan antosianin jenis sianidin. Aktivitas antioksidan diukur melalui peredaman radikal bebas DPPH dengan spektrofotometri UV-Vis pada panjang gelombang 517 nm. Hasil Penelitian menunjukkan ekstrak daun andong merah memiliki potensi antioksidan kuat dengan nilai IC50 64.5197 µg/mL terhadap radikal bebas DPPH dan vitamin C sebagai pembanding menunjukkan potensi antioksidan sangat kuat dengan nilai IC50 2.12 µg/mL.Kata Kunci : Daun andong merah, antioksidan, DPPH
Integritas Pendidikan Kewirausahaan dalam Mewujudkan Muslim Entrepreneurship (Studi Kasus Mahasiswa FEBI IAIN Bukittinggi)
Authors: Sonita Era , Helmi Helmi 
Published: July 2021

The main objective of the Faculty of Economics and Islamic Business (FEBI) IAIN Bukittinggi is to prepare the graduates who can compete in both academic and non-academic fields. Accordingly, researcher would like to deeply examine the synergy of attitude and knowledge to develop entrepreneurship spirit of the students of Faculty of Economics and Islamic Business (FEBI) IAIN Bukittinggi. After analyzed qualitatively using; SWOT analysis, SWOT Matrix, and Charge Table Score, it can be pointed out that the synergy of attitude and knowledge in the development of entrepreneurship of students namely; 1) To grow values: religious, honesty, tolerance, ideas and creativity, awareness of the norms and rules, a strong spirit in learning, a strong drive to excel, confidence, and independence, interest, perseverance, and motivation, the desire to explore and produce economic resources, entrepreneurial spirit and entrepreneurship, And, 2). Realizing knowledge about; entrepreneurship ideas that suits the needs of the market, the development of business prospects, and business management.
Padre Tierra
Authors: Zaro Mariano , Falconer Blas 
Published: July 2021

Sobre PADRE TIERRA
El poema Padre Tierra es una conversación con la figura del padre. Una conversación que retrata al padre y a la vez, revela la identidad del hijo: sus miedos, sus descubrimientos y su paso de la infancia a la edad adulta. Se trata de un poema de búsqueda y aprendizaje. El lenguaje, lleno de referencias sensoriales a la naturaleza, nos adentra en un universo privado lleno de escenas cotidianas cargadas de valores simbólicos.
El poema ha sido escrito originalmente en español. La versión que aquí se adjunta es una versión bilingüe español e ingl´´´´és.
El texto original de PADRE TIERRA consta de 50 segmentos. Algunos de ellos han sido publicados. Los 8 segmentos que aquí se adjuntan para publiación son inéditos.
Analisis Fungsi Pengawasan Kinerja Kontraktor terhadap Pelaksanaan Proyek Jalan Pada Dinas Pekerjaan Umum dan Bina Marga Kabupaten Musi Banyuasin
Authors: Rakhmalina Ika 
Published: July 2021

ABSTRACTThis study is entitled Analysis of the Performance Monitoring Function of Contractors on the Implementation of Road Projects at the Public Works and Bina Marga Office of Musi Banyuasin Regency. The purpose of this study is to determine the Contractor Performance Monitoring Function on the Implementation of Road Projects at the Public Works and Bina Marga Offices of Musi Banyuasin Regency. The research method used in this research is descriptive quantitative method. This study concludes, first the Supervision Function has been implemented well and effectively and has clarity in its implementation and sanctions determined in accordance with the agreement. Secondly, every year there are still projects that are not on time. Third, the Target / Performance of Road Projects in the Busi Marga Public Works Office of Musi Banyuasin Regency can be seen from the 6 performance measurement indicators carried out by the Musi Banyuasin Public Works Department, which are quite good, but the indicators for the availability of facilities and infrastructure for disaster have not been carried out properly because a priority.Keywords : monitoring performance, administration, project implementation and project targetsABSTRAKPenelitian ini berjudul Analisis Fungsi Pengawasan Kinerja Kontraktor Terhadap Pelaksanaan Proyek Jalan Pada Dinas Pekerjaan Umum dan Bina Marga Kabupaten Musi Banyuasin Tujuan dari penelitian ini adalah untuk mengetahui Â Fungsi Pengawasan Kinerja Kontraktor Terhadap Pelaksanaan Proyek Jalan Pada Dinas Pekerjaan Umum dan Bina Marga Kabupaten Musi Banyuasin. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif diskriptif. Penelitian ini menyimpulkan, pertama Fungsi Pengawasan sudah dilaksanakan dengan baik dan efektif serta memiliki kejelasan dalam pelaksanaannya dan sanksi yang ditetapkan sesuai dengan kesepakatan. Kedua, setiap tahun masih ada proses pengerjaan proyek yang tidak tepat waktu. Ketiga, Target/ Kinerja Proyek Jalan di Dinas Pekerjaan Umum Bina Marga Kabupaten Musi Banyuasin dilihat dari 6 indikator pengukuran kinerja yang dilaksanakan Dinas Pekerjaan Umum Bina Marga Kabupaten Musi Banyuasin, sudah cukup baik, namun indikator ketersediaan sarana dan prasarana kebinamargaan belum dilaksanakan dengan baik disebabkan belum menjadi prioritas.Kata kunci : pengawasan kinerja, administrasi, pelaksanaan proyek dan target proyek
STANDARDIZATION AND TOXICOLOGICAL STUDIES OF THE LEAF OF SENNA SIAMEA IRWIN & BARNEBY (FABACEAE) COLLECTED FROM AGULU IN AWKA SOUTH OF ANAMBRA STATE
Authors: Ezea Chinasa Charity 
Published: July 2021

Background: Pharmacognostic standards and toxicological studies of the leaf of S. siamea were carried out. Objectives: To determine the quantitative phytochemical constituents present, pharmacognostic standards and toxicological effect of the methanol leaf extract and fractions of S. siamea. Methodology: Fresh leaves of S. siamea were collected, dried, pulverizes to powder and subjected to pharmacognostic and quantitative phytochemical analysis. The pulverized leaves were cold macerated in methanol for three days with intermittent shaking and exchange of fresh solvent every 24 hrs (aliquot extraction). Fractionation was done using n-hexane, ethylacetate and butanol. Chromatographic analysis of the methanol extract and fractions were obtained using standard methods. The methanol extract and fractions where screened for phytochemical constituents and toxicological effects using standard methods. Acute toxicity (LD50) of the extract was determined using Lorke’s method. Results: Macroscopic and microscopic examinatios revealed acute apex, pinnate veination and diacytic stomata, trichomes respectively. Phytochemical screening of the extract and fractions revealed the presence of flavonoids, alkaloids, saponins, tannins etc. Proximate analysis of S. siamea revealed moisture content of 5.50 %, total ash value of 15.00 %, water soluble ash of 2.00 % etc. The LD50 was found to be > 5000 mg/kg. Increase in ALT, AST and ALP when metanol extract and fractions were administered were not statistically different from the control group, indicating no hepatotoxic potential. Increase in PCV, Hb and RBC when metanol extract and fractions were administered were not statistically different from control group. The non-significant decrease in the levels of ALP, ALT and AST indicates that the extract has possible hepatoprotective effect. The non-significant decrease in the levels of RBC, Hb and PCV indicates that the extract does not affect the heamatopoietic system when administered orally and at the doses used in the study. Conclusions: Specific standards obtained from the study may be compiled into a monograph of S.siemea plant that may constitute in herbal pharmacopoeia.
Lung cancer (C33, 34). Morbidity, mortality, accuracy of registration, localization and histological structure (population study)
Authors: Merabishvili Vakhtang , Iurkova Iuliia , Shcherbakov Aleksandr , Levchenko Evgenii , Barchuk Anton , Krotov Nikolai , Merabishvili Elvira 
Published: July 2021

Lung cancer (LC) is the main cause of morbidity and mortality in the population of Russia and many economically developed countries of the world. At the same time, referring to localizations with a high mortality rate, the official data on the number of recorded primary cases (which form the incidence rate) are significantly underestimated, which is confirmed by the registration reliability index, which in many territories is higher than critical values. The aim of our study is to present the real state of the prevalence of PC in Russia, based on the newly created database (DB) of the population cancer register (PRR) of the Northwestern Federal District of the Russian Federation (NWFD RF) — the only one in Russia. We analyzed the loss of the number of primary patients who were not included in the state reporting, showed the real value of the achieved death rate of patients in the first year of dispensary observation, calculated the patterns of annual mortality of patients, the median of survival and 1 and 5-year survival of patients with lung cancer based on the database of the population cancer registry. Northwestern Federal District of the Russian Federation, on the materials of which for the first time in Russia the dynamics of changes in the detailed localization and histological structure of lung cancer was traced.
Endoscopic endosonography with fine-needle aspiration biopsy in the diagnosis of pancreatic tumors
Authors: Mikhetko Andrey , Artemieva Anna , Ivko Olga , Tkachenko Oleg , Grinkevich Marina , Sidorova Aleksandra , Petrik Iurii 
Published: July 2021

Objectives of the study: efficiency assessment of cytological methods in the diagnosis of pancreatic tumors.
Material and methods. Our study includes results of 163 pancreatic fine needle aspirations of solid and cystic tumors, from 160 patients of the N.N. Petrov Cancer Research Center for the 4-year period (2016–2020).
Results. Representative cell material for morphological studies was obtained in 98.6% of cases. The results of cytological examination of 35 patients with pancreatic tumors were compared with histological data. Malignant process was correctly established in 30 out of 32 patients, benign process- in all three cases. The sensitivity of cytological examination was 93.1%, specificity — 100%.
Conclusion. Pancreatic fine-needle aspiration cytology is safe, rapid, accurate and cost‐beneficial modality of investigation of pancreatic mass lesion.
Dynamics of changes in renal function in patients undergoing radical cystoprostatectomy with various variants of heterotopic reservoir
Authors: Petrosyan Hayk , Sckolnik Mikhail , Keln Artem , Lykov Alexander , Kupchin Alexander , Ivanov Dmitry 
Published: July 2021

Relevance. Chronic renal failure in patients undergoing radical cystoprostatectomy (RCPE) with various variants of urine derivation is one of the significant problems that requires an interdisciplinary approach. To date, there is an insufficient number of studies comparing a significant decrease in glomerular filtration rate (GFR) between different types of urine diversion after radical cystectomy.
Purpose of research. To study glomerular filtration rate (GFR) indicators in patients who underwent radical cystectomy with a heterotopic Bricker reservoir and compare them with similar indicators in patients who underwent radical cystectomy with a « V « shaped heterotopic reservoir. To compare early postoperative complications in patients who underwent radical cystoprostatectomy with the formation of a heterotopic Bricker reservoir and with a modified V-shaped heterotopic reservoir.
Materials and methods. To study and compare the dynamics of glomerular filtration rate (GFR), we retrospectively selected patients after radical cystoprostatectomy with heterotypic ileocystoplasty. Patients were divided into two groups: the control group — patients with radical cystoprostatectomy and Bricker ileocystoplasty (n=46), the study group — patients with radical cystoprostatectomy and modified V-shaped heterotopic ileocystoplasty (n=49).
Results. At the stage of discharge of patients from the hospital after radical cystoprostatectomy, the level of glomerular filtration rate (GFR) was not statistically significant differences between the study and control group (P=0.3791), including patients with the presence of hydronephrosis (P=0.4664).
The difference in glomerular filtration rate (GFR) between the study group and the control group was statistically significant after 6 years of dynamic follow-up. As a result, it can be argued that the dynamics of glomerular filtration rate (GFR) reduction in the study group is lower than in the control group. A particularly significant difference in glomerular filtration rate (GFR) was observed in patients with existing hydronephrosis at the preoperative stage.
Conclusion. Modified «V» — shaped heterotopic urine derivation can be recommended for patients who have undergone radical cystoprostatectomy, especially with existing hydronephrosis at the preoperative stage.
This method should be used in patients with chronic pyelonephritis against the background of previously diagnosed ureterohydronephrosis, which is a fairly frequent consequence of the invasive nature of the growth of bladder cancer with ureteral obstruction.
The effect of constant light and melatonin on urethane-induced lung carcinogenesis in mice and expression of clock genes and proteins
Authors: Gubareva Ekaterina , Iurova Mariia , Tyndyk Margarita , Maydin Mikhail , Yanus Grigorii , Egormin Petr , Panchenko Andrey , Anisimov Vladimir 
Published: July 2021

Introduction. Circadian rhythms are an adaptational mechanism to day-night cycle. At the cellular level rhythms are supported by oscillations of transcription of Bmal1, 2, Clock and Npas2, Per1-3, Cry1, 2 clock genes; in the organism rhythms are synchronized with melatonin, the "hormone of darkness". Reliable data have been obtained that disruption of biological "clocks" at the cellular and/or organism level are associated with carcinogenesis, but the experimental results in this direction remain incomplete.
Aim. Assessment of the continuous lighting and melatonin administration effects on chemically induced carcinogenesis in mice and expression of clock genes and proteins in normal and tumor lung tissue.
Materials and methods. Lung tumors were induced by urethane in 120 male SHR mice. Animals were kept at constant (LL) or standard (LD) light; half of the animals received melatonin (MT) daily at 20 mg/l at night with water for 45 weeks of experiment. At the end of the experiment, the frequency and multiplicity of lung tumours of different size were assessed. Expression of clock genes Clock, Bmal1, Cry1 was assessed in tumor samples and normal lung tissue by real-time PCR; protein content of BMAL1, CLOCK, CRY1 and PER2 was determined by immunohistochemistry. Statistical data were processed using the programs MS Excel 2007, GraphPad Prism 6.0 with commonly used statistical criteria.
Results. The number of animals with lung tumors was between 89 and 100% in different groups. Large tumors (>2 mm) were more frequently observed in LL group (62 tumors out of 294, 21,1%) than in LD group (59 tumors out of 405, 14,6%, p=0,0245). Administration of exogenous melatonin at constant lighting statistically significantly reduced the frequency of large tumors (28 tumors out of 320, 8.8%, p=0,0001 in comparison with LL). In normal lung tissue of animals kept at constant lighting (LL) the increase in relative expression of clock genes in comparison with LD group was revealed: Bmal1 by 3,1 times (p=0,02) and Cry1 by 3,6 times (p=0,0002). No such differences were found for Clock gene. The relative content of BMAL1 and CLOCK proteins in all experimental conditions was higher in adenomas and adenocarcinomas compared to normal tissue.
Conclusion. Constant lighting promotes the development of chemically induced lung tumors, and melatonin administration inhibits carcinogenesis under constant lighting.
The content of BMAL1 and CLOCK transcription activator proteins in lung tumors was found to increase in comparison with normal tissue, whereas no increase in the expression level of corresponding genes in tumors was observed.
Hemşirelik Öğrencilerinde İnternet Bağımlılığı
Authors: DOST Ayşe , KÖKCÜ DOĞAN Aysel , ASLAN Derya 
Published: July 2021

Amaç: Çalışmanın amacı hemşirelik öğrencilerinin internet bağımlılığı düzeylerini belirlemektir.
Yöntem: Tanımlayıcı olarak gerçekleştirilen çalışmanın örneklemini Ekim 2020-Ocak 2021 eğitim öğretim yılında öğrenim gören 238 hemşirelik öğrencisi oluşturmuştur. Veriler araştırmacılar tarafından hazırlanan “Kişisel Bilgi Formu” ve 2010 yılında Günüç ve Kayri tarafından Türkçe’ye uyarlanarak geçerlilik ve güvenirlilik çalışması yapılan "İnternet Bağımlılığı Ölçeği (İBÖ)" ile toplanmıştır.
Bulgular: Öğrencilerin yaş ortalamaları 19.44 ± 1.77 yıl olup, %88.2’si kadındır. Öğrencilerin %14.7'sinin günde interneti 30-40 kez kontrol ettiği, %31.1’inin 5 saat ve üzerinde akıllı telefon kullandığı, %34.5’inin en çok sosyal medya (facebook, twitter vb.) için internet kullandığı saptanmıştır. Öğrencilerin İnternet Bağımlılık Ölçeği’nden aldıkları puan ortalaması 89.87±20.60 (min:44, max:135) bulundu. Ölçek alt boyutlarının puan ortalamaları incelendiğinde, “yoksunluk” 32.58±8.56, “kontrol güçlüğü” 24.05±7.72, “işlevsellikte bozulma” 15.27±5.91 ve “sosyal izolasyon” alt boyut puanının 17.96±3.23 olduğu tespit edilmiştir. Öğrencilerin cinsiyet, internet kullanma süresi, akıllı telefon kontrol etme sıklığına göre İBÖ puan ortalamasının istatistiksel olarak anlamlı farklılık (p
Maksimal sitoredüksiyon sonrası Hipertermik İntraperitoneal Kemoterapi uygulamasının platin dirençli ve parsiyel duyarlı rekürren epitelyal over kanserinde sağ kalıma etkisi
Authors: OZGUN Yigit Mehmet , ÖZ Murat , ÖTER Volkan , ÇOLAKOĞLU Muhammet Kadri , PİSKİN Erol , AYDİN Osman , BOSTANCİ Erdal 
Published: July 2021

Amaç: Over kanserlerinde nüks genellikle peritoneal metastaz ile olmaktadır. Bu durumda tedavi seçenekleri arasında sitoredüktüf cerrahi (SRC) ve hipertermik intraperitoneal kemoterapi (HİPEK) önemli yer tutmaktadır. Özellikle platin dirençli ve parsiyel duyarlı rekürren epitelyal over kanserlerinde bu tedavi daha da önem kazanmaktadır. Çalışmamızda bu hasta grubuna uyguladığımız sitoredüktüf cerrahi ve hipertermik intraperitoneal kemoterapi tedavisin sonuçlarını analiz ettik.
Gereç ve Yöntemler: 2014-2021 tarihleri arasında peritoneal nüks nedeni ile opere edilen platin dirençli ve parsiyel duyarlı patolojisi yüksek dereceli seröz over karsinom olan hastalar geriye dönük olarak incelendi. Çalışmaya sadece makroskopik rezidü tümör kalmayacak şekilde SRC ve HİPEK uygulanan hastalar dahil edildi. Hastaların erken ve uzun dönem sonuçları, takip sürecinde nüks gelişimi, hastalıksız ve toplam sağ kalım süreleri analiz edildi.
Bulgular: Toplam 13 hasta çalışmaya dahil edildi. Hastaların, peritoneal karsinomatoz indeksi (PKİ), 3-25 arasında ve ortanca yaş 54 (32-77  11,5 SD) olarak saptandı. Bir hastaya hem sekonder hem tersiyer SRC ve HİPEK uygulandı. Ortanca hastane yatış süreleri ve takip süreleri sırası ile 14 gün ve 42 ay olarak bulundu. Beş hastada post operatif komplikasyon gözlendi. Tüm hastaların median hastalıksız sağ kalım (DFS) 41 ay, median sağ kalım (OS) 49 ay olarak bulundu.
Sonuç: Platin dirençli ve parsiyel duyarlı rekürren epitelyal over kanserlerinde SRC ve HİPEK, kabul edilebilir morbidite oranları ile yapılabilmektedir. Makroskopik tümör bırakılmadan uygulanan sitoredüksiyon ile uzun sağ kalım sağlanabilmektedir. Sekonder ve tersiyer cerrahiler seçilmiş hastalarda faydalıdır.