bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quorum Sensing Mediated Pathogenicity, Virulence Genes and Class 1 Integron in Carbapenem-Resistant Clinical Pseudomonas Aeruginosa Isolates
Authors: Başkan Ceren , Sırıken Belgin , Tüfekci Enis Fuat , Kılınç Çetin , Ertürk Ömer , Erol İrfan 
Published: December 2021

Abstract
Carbapenems are the most effective agents for treating carbapenem-resistant clinical P. aeruginosa (CRPsA) infections. During an infection, a quorum-sensing (QS) system and its regulating virulence genes have a great role. The aim of the study was to detect the presence of a las and rhl QS system and related virulence genes and a class 1 (Cls1) integron. A total of 52 CRPsA isolates obtained from Kastamonu, Turkey was analyzed. A conventional culture method, an oprL gene-based molecular assay for P. aeruginosa isolates, and an automated VITEK-2 compact system were applied for the isolation and identification of CRPsA isolates. The oprL gene was detected in all of the isolates tested. At least one of the las or rhl system genes was detected in 98.07% of the isolates, and the percentage of las system genes (98.07%) were higher than that of rhl system genes (90.38%). algD, lasB, toxA and aprA genes were detected in between 46.15% and 88.46% of the isolates, and co-existence of four genes were detected in 40.38% of the isolates. Cls1 integron and slime production using Congo Red Agar (CRA) were present in 51.92% and 67.30%, respectively, of the isolates. There was a significant positive correlation (p <.10) between the las system and the rhl system and a strongly positive correlation (p<.01 or p <.05) between the rhl system-four virulence genes and slime production-and among some virulence genes. In conclusion, the CRPsA isolates tested in the study are highly virulent and QS systems have a significant role in pathogenesis.
Potential Room Temperature Superconductivity in Clathrate Lanthanide/Actinides Octadechydrides at Extreme Pressures
Authors: Zhong Xin , Sun Ying , Iitaka Toshiaki , Xu Meiling , Liu Hanyu , Chen Changfeng , Ma Yanming 
Published: December 2021

Abstract
Atomic metallic hydrogen (AMH) hosting high-temperature superconductivity has long been considered a holy grail in condensed matter physics and attracted great interest, but attempts to produce AMH remain in intense exploration and debate. Meanwhile, hydrogen-rich compounds known as superhydrides offer a promising route toward creating AMH-like state and property, as showcased by the recent prediction and ensuing synthesis of LaH10 that hosts extraordinary superconducting critical temperatures (Tc) of 250-260 K at 170-190 GPa. Here we show via advanced crystal structure search a series of hydrogen-superrich clathrate compounds MH18 (M: rare-earth/actinide metals) comprising H36-cage networks, which are predicted to host Tc up to 329 K at 350 GPa. An in-depth examination of these extreme superhydrides offers key insights for elucidating and further exploring ultimate phonon-mediated superconductivity in a broad class of AMH-like materials.
Trisomy 18 – When the Diagnosis Is Compatible With Life
Authors: Silva Catarina , Ferreira Mariana Cortez , Saraiva Jorge , Cancelinha Cândida 
Published: December 2021

Abstract
Trisomy 18 is an autosomal chromosomal disorder characterized by the presence of an extra 18 chromosome. In the last decades, and as the therapeutic options have become more relevant, the medical community witnessed a paradigm shift on the offer of treatment to these children.This is a retrospective, cohort study that strives to characterize the clinical path and survival of the children with the diagnosis of trisomy 18, accompanied in a tertiary pediatric hospital between 1995 and 2020.Six children were identified with trisomy 18, two of them mosaic (33,3%) and four were females (66,7%). All had cardiovascular, cognitive and physical development anomalies or minor congenital anomalies (n=6, 100%) and most presented musculoskeletal anomalies (n=5, 83,3%) and feeding difficulties (n=4, 66,7%). Four children (66,7%) were reliant on devices or equipment and all needed chronic medication (n=6, 100%). Two children (33,3%) were submitted to surgical interventions. Four children (66,7%) were hospitalized in the last year of life. A decision of limitation of therapeutic effort was present in three cases (50%) with one child being referenced to pediatric palliative care (16,7%). One-month, one-year and ten-year survival were 66,7% (n=4), 33,3% (n=2, both mosaic), and 16,7% (n=1, mosaic) respectively.Conclusions: Knowledge on the clinical picture is of great importance regarding the neonatal care and the decisions about invasive treatments, which can involve ethical issues, highlighting, concurrently, the need for attempted referral of these children to pediatric palliative care teams.
Stability analysis of rock slope and calculation of rock lateral pressure in foundation pit with structural plane and cave development
Authors: Xu Jin , Wang Yansen 
Published: December 2021

Abstract
In this study, numerical simulations were carried out to analyze the influence of caves in different positions and shapes, in combination with structural planes, on the stability of the slope and the failure characteristics of a rock slope in a deep foundation pit with high inclination structural planes and cave development. The schemes for substituting a single karst cave for karst caves were constructed. Based on the penetration failure characteristics of karst caves between parallel structural planes, methods for calculating the safety factor of the rock foundation pit and the upper bound of the lateral pressure of the supporting structure under the combined influence of the caves and structural planes were developed, which can be used to assess the safety factor of a rock mass and to calculate the lateral pressure under complex geological conditions.
Socio-economic Study of Conservation and Rehabilitation of Tropical Peatland With Agroforestry Systems in Central Kalimantan, Indonesia
Authors: Elia Andrie , Jaya Adi , Antang Emmy Uthanya , Octora Merrisa , Indrajaya Kusnida , Dohong Salampak 
Published: December 2021

Abstract
Current studies on tropical peatlands in Indonesia are mostly focused on the impacts of management practices on the environment. Studies on efforts to conserve and rehabilitate the degradation of tropical peatland involving farmers through agroforestry systems have been limited. By employing the qualitative survey with semi-structured interviews and field observations to agroforestry locations in two villages of Tumbang Nusa and Kalampangan, Central Kalimantan, Indonesia aims to fill those research gaps. The results showed that the main motivation of farmers in starting agroforestry activities was the understanding that there would be limited trees in the future, and planting trees with a combination of intercrops provided adequate income. Agroforestry farmers who devote considerable time to agroforestry can meet the family's economic needs. Although further guidance is not typically provided, government intervention through tree planting programs also stimulates agroforestry activities. Intensive management of intercrops in various types can provide a good income. For intensive intercropping options, farmers follow market demand, while less intensive farmers prefer plants that do not require intensive management. Trees planted in agroforestry systems are only given fertilizer at the initial planting stage. Some farms receive fertilizer subsidies from government support programmes, but fertilizers are obtained from intercropping at the following stage. The study results imply that the community needs to get knowledge and training on agroforestry, which can be a way of conserving and rehabilitating tropical peatlands and a source of income.
Species Assemblage of Birds’ Community in Protected Areas of Delhi-NCR
Authors: chatrath deepali , Bhatt Lipakshi , Sethy Janmejay , Murthy Meesala K. 
Published: December 2021

Abstract
Green spaces in cities especially in the capital city of India provide necessary recreational, social and psychological benefits to stressing residents of the city. Cities and towns depict the extreme human-modified environments with only remnants of the original habitats present. Study undertaken to know the abundance, diversity and species richness of avian fauna in urban protected landscapes of Delhi, NCR. In the following paper, the methods include data is extracted from e-Bird of past 40 years to illustrate the changing trend of bird species from 1980-2019 from 7 greenspaces of Delhi-NCR which are Aravalli Biodiversity Park, Asola Bhatti Wildlife Sanctuary, Deer Park, Dheerpur Wetland, National Zoological Park, Northern Ridge, Okhla Bird Sanctuary, Sanjay Van, Yamuna Biodiversity Park and analysed as box plots using PAST. The result showed a varied trend from 1980-2019, which included the usage of e-Bird by the period. The result indicated that the recent decade is well updated with data on e-Bird, hence several birds’ individual is maximumly observed from 2011-2019. The study has shown the wavy trend from 1980-2019 in species composition in the capital city of India. This also suggest that people have started recording observation on a single platform and shown interest in last decade. This study will lead to taking the necessary step to maintain the avian biodiversity in the green spaces of the capital city- Delhi-NCR.
A Molecular View of Amyotrophic Lateral Sclerosis Through the Lens of Interaction Network Modules
Authors: Jensen Klaus Højgaard , Stalder Anna Katharina , Wernersson Rasmus , Roloff-Handschin Tim-Christoph , Hansen Daniel Hvidberg , Groenen Peter MA 
Published: December 2021

Abstract
Background: Despite the discovery of familial cases with mutations in Cu/Zn-superoxide dismutase (SOD1), Guanine nucleotide exchange C9orf72, TAR DNA-binding protein 43 (TARDBP) and RNA-binding protein FUS as well as a number of other genes linked to Amyotrophic Lateral Sclerosis (ALS), the etiology and molecular pathogenesis of this devastating disease is still not understood. As proteins do not act alone, conducting an analysis of ALS at the system level may provide new insights into the molecular biology of ALS and put it into relationship to other neurological diseases.Methods: A set of ALS-associated genes/proteins were collected from publicly available databases and text mining of scientific literature. We used these as seed proteins to build protein-protein interaction (PPI) networks serving as a scaffold for further analyses. From the collection of networks, a set of core modules enriched in seed proteins were identified. The molecular biology of the core modules was investigated, as were their associations to other diseases. To assess the core modules’ ability to describe unknown or less well-studied ALS biology, they were queried for proteins more recently associated to ALS and not involved in the primary analysis.Results: We describe a set of 26 ALS core modules enriched in ALS-associated proteins. We show that these ALS core modules not only capture most of the current knowledge about ALS, but they also allow us to suggest biological interdependencies. In addition, new associations of ALS networks with other neurodegenerative diseases, e.g. Alzheimer’s, Huntington’s and Parkinson’s disease were found. A follow-up analysis of 140 ALS-associated proteins identified since 2014 reveals a significant overrepresentation of new ALS proteins in these 26 disease modules.Conclusions: Using protein-protein interaction networks offers a relevant approach for broadening the understanding of the biological context of known ALS-associated genes. Using a bottom-up approach for the analysis of protein-protein interaction networks is a useful method to avoid bias caused by over-connected proteins. Our ALS-enriched modules cover most known biological functions associated with ALS. The presence of recently identified ALS-associated proteins in the core modules highlights the potential for using these as a scaffold for identification of novel ALS disease mechanisms.
Topic overlap and research waste at the ‘Overviews of systematic reviews’ level: a meta-research study
Authors: Lunny Carole , Zhang Jia He , Chen Alyssa , Neelakant Trish , Shinger Gavindeep , Stevens Adrienne , Tasnim Sara , Sadeghipouya Shadi , Adams Stephen , Zheng Yi Wen , Lin Lester , Yang Pei Hsuan , Dosanjh Manpreet , Ngsee Peter , Ellis Ursula , Shea Beverley J. , Reid Emma K. , Wright James M. 
Published: December 2021

Abstract
Background
Multiple ‘overviews of reviews’ conducted on the same topic (“overlapping overviews”) represent a waste of research resources and can confuse clinicians making decisions amongst competing treatments. We aimed to assess the frequency and characteristics of overlapping overviews.
Methods
MEDLINE, Epistemonikos and Cochrane Database of Systematic Reviews were searched for overviews that: synthesised reviews of health interventions and conducted systematic searches. Overlap was defined as: duplication of PICO eligibility criteria, and not reported as an update nor a replication. We categorized overview topics according to 22 WHO ICD-10 medical classifications, overviews as broad or narrow in scope, and overlap as identical, nearly identical, partial, or subsumed. Subsummation was defined as when broad overviews subsumed the populations, interventions and at least one outcome of another overview.
Results
Of 541 overviews included, 169 (31%) overlapped across similar PICO, fell within 13 WHO ICD-10 medical classifications, and 62 topics. 148/169 (88%) overlapping overviews were broad in scope. Fifteen overviews were classified as having nearly identical overlap (9%); 123 partial overlap (73%), and 31 subsumed (18%) others.
Conclusions
One third of overviews overlapped in content and a majority covered broad topic areas. A multiplicity of overviews on the same topic adds to the ongoing waste of research resources, time and effort across medical disciplines. Authors of overviews can use this study and the sample of overviews to identify gaps in the evidence for future analysis, and topics that are already studied which do not need to be duplicated.
A Rare Cause of Septic Shock Secondary to Trauma: Morel Lavallée Lesion - Case Report
Authors: Gunay Mehmet , Mollavelıoglu Baran , Gok Kaan Ali Fuat , Ilhan Mehmet , Ertekın Cemalettın 
Published: December 2021

Abstract
Introduction Morel Lavallée lesion is a hemolymphatic collection in between muscular fascia that can be caused by the separation of soft tissue and muscular fascia in degloving fashion. Morel Lavallée lesion is an infrequent lesion but should be known for medico-legal reports Morel Lavallée is a rare presentation that can cause life-threatening septic and hemorrhagic shock. Case PresentationIn this case report we are going present Morel Lavallée lesion which can present with septic shock and bleeding and can be mortal. Our patient, fourty seven years old male, arrived at the emergency department with an ambulance 1 hour after an extravehicular traffic accident. Apart from a right hemopneumothorax with multiple rib fractures, grade 2 laceration in spleen and bilateral kidneys, zone 2 fracture of sacrum, computer tomography (CT) revealed a closed, degloving injury of the pelvis , also known as a Morel-Lavallée lesion. On CT, Morel Lavallée lesion appear as well-defined, encapsulated fluid collections that occasionally show fluid fluid levels .. Heavy fluid collection was detected in control CT which was actually a collection infected hematoma in the operative setting. Patient was diagnosed in the first 12 hours and necrotic tissues were debrided. Patient was considered deceased after 15 days without any improvement in his GCS score.ConclusionsThere is one report that describe mortality after Morel Lavallée lesion in the autopsy setting. Early diagnosis and treatment are essential to decrease severity of necrosis and sepsis though our patient has deceased due to complications of sepsis
A Comparison of Survival after Radiosurgery in Non-Small Cell Lung Cancer Patients with One versus More than Twenty Brain Metastases
Authors: Wei Zhishuo , Niranjan Ajay , Abou-Al-Shaar Hussam , Deng Hansen , Albano Luigi , Lunsford L. Dade 
Published: December 2021

Abstract
Background

Whether the number or cumulative volume of brain metastases affects survival in patients with metastatic non-small cell lung cancer (NSCLC) remains controversial. We sought to compare whether patients with solitary brain disease had better outcomes than patients with ≥ 20 brain metastases.
Methods

Between 2014 to 2020, 26 NSCLC patients (925 tumors) underwent stereotactic radiosurgery (SRS) for ≥ 20 metastases in a single procedure (median margin dose = 16 Gy, median cumulative tumor volume = 4.52 cc); 56 patients underwent SRS for a single metastasis (median margin dose = 18 Gy, median volume = 4.74 cc). The overall survival (OS), local tumor control (LC), adverse radiation effect (ARE) risk, and incidence of new tumor development were compared.
Results

No difference in OS was found between patients with ≥ 20 brain metastases (median OS = 15 months) and patients with solitary metastasis (median OS = 12 months; p = 0.3). In the solitary tumor cohort, two of 56 (3.5%) tumors progressed whereas in the ≥ 20 cohort only 3 of 925 (0.3%) tumors showed progression (*p = 0.0013). The rate of new tumor development was significantly higher in patients with ≥ 20 tumors (***p = 0.0001). No significant difference of ARE rate was found (7.5% for ≥ 20 tumors vs. 8.7% for single metastasis).
Conclusions

Patients with ≥ 20 tumors showed significantly better LC with similar OS compared to patients with solitary tumors. Current guidelines that restrict the role of SRS to patients with 1-4 tumors should be revised.
approach to polarity sensitivity and negative concord by lexical underspecification
Authors: Tonhauser Judith 
Published: December 2021

This paper presents a dynamic semantic approach to the licensing of Polarity Sensitive Items (PSIs) and n-words of Negative Concord. We propose that PSIs are unified by the semantic scale property, which is responsible for their sensitivity to the context; we develop a semantic licensing analysis based on Fauconnier's (1975) scales and Ladusaw's (1979) notion of entailment. The first part of the paper concludes with a formalization of semantic licensing in the sense of Ladusaw (1979) within HPSG (see, e.g., Pollard & Sag (1994)) which allows for a uniform treatment of the licensing of PSIs and n-words of Negative Concord and accounts for the disambiguating nature of PSIs in scopally ambiguous sentences.
The second part of the paper is concerned with the limitations of semantic licensing, which, we claim, needs to be sensitive to the context. We present the discussions of, e.g., Heim (1984) and Israel (1996) with respect to the importance of the context in particular licensing constellations, and then turn to linearity constraints on licensing. We present data from German which may not be accounted for by linearity constraints and sketch an analysis for this data which supports the necessity of context-sensitive semantic licensing.
A-subjects and control in Halkomelem
Authors: Gerdts Donna B. , Hukari Thomas E. 
Published: December 2021

We discuss evidence in Halkomelem, a Coast Salish language of British Columbia, which supports the hypothesis put forward by Manning and Sag (1999) that a universal passive argument structure (ARG-ST) is complex and has two a-subjects. We argue that morphological and syntactic control phenomena in Halkomelem are best described by saying that an a-subject is accessible, where an a-subject is the first argument on an argument structure list.
ARG-ST <bi <a, Proi, ...>>
The Halkomelem passive data show that two notions of subject are essential for capturing control phenomena. One set of constructions-motion auxiliaries, desideratives, and reflexive causatives-involve linking to the internal a-subject. One construction-the control construction–links to either the highest a-subject or the internal a-subject. Similar conclusions have been drawn for data from Russian (Perlmutter 1984), Philippine languages (Schachter 1984), and other languages of the world. As Manning and Sag (1998) point out, one does not have to draw the conclusion that passive must be given a multilevel syntactic analysis from such data. Rather, their analysis of passive, which posits a complex argument structure, easily accounts for Halkomelem. Control facts in Halkomelem, with examples drawn from both morphological and syntactic constructions, can be added to the catalog of phenomenon that support this view of the passive.
was-w construction in German
Authors: Hinrichs Erhard W. , Nakazwa Tsuneko 
Published: December 2021

The so-called was-w-construction in German has received a fair amount of attention in recent syntactic theorizing. Most of the discussion has focused on the properties of was.
One line of research maintains that was is a scope marker that indicates the semantic scope of the wh-phrase in the embedded interrogative clause. The alternative view, usually referred to as the indirect analysis, was first developed with respect to Hindi (Dayal 1994) and then generalized to German (Dayal 1996). It holds that the was of the was-w-construction is associated not with the embedded wh-phrase, but rather with the embedded clause as a whole.
Hinrichs and Nakazawa present some novel evidence in favor of an indirect analysis of the was-w construction. However, the main focus of their research is on two questions that by comparison have received little attention, namely:

what is the set of matrix predicates that can enter into this construction, and
how can one account for the curious fact that predicates that ordinarily do not license wh-complements allow such complements in the was-w-construction?

On the basis of Ginzburg and Sag's verb classification (Ginzburg and Sag, in preparation) Hinrichs and Nakazawa identify a natural class of predicates that license this construction and utilize the notion of type coercion to account for the apparent mismatch between the syntactic form of the embedded interrogative and its semantic function.
Without an index
Authors: Branco António 
Published: December 2021

Departing from the exhaustive indexation, syntax-driven approach to binding, we argued for an alternative, semantics-oriented rationale for binding principles. Under this new understanding of the nature of grammatical constraints on anaphoric binding, these principles are viewed as contributing to circumscribe the contextually determined semantic value of anaphoric nominals. This conceptual shift helps to find a fully fledged formal specification of binding principles with the HPSG lean description formalism where these constraints are entered in the grammar as part of the information kept at the lexical entries of anaphoric expressions.
Out of control
Authors: Oshima David Y. 
Published: December 2021

In this paper I develop a unified analysis of the Japanese passive, which provides a uniform syntactic/semantic representation of the alleged varieties of passives (direct, indirect, possessive) as a complex predicate that encodes the triadic relation of "lack of control" among an agent, undergoer and event. Various differences among the direct, possessive, and indirect passives (the adversative effect implicature, the possibility of reflexive binding, the animacy constraint on the subject, etc.) are explained as cooperative effects of the core syntactic/sematic properties of the passive morpheme -(r)are and functional/pragmatic factors like conversational implicature and empathy constraints.