bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current management of adults receiving oral anti-cancer medications: A scoping review protocol
Authors: Richmond Janice P. , Kelly Mary Grace , Johnston Alison , Hynes Lisa , Murphy Patrick J. , Murphy Andrew W. 
Published: June 2021

Oncology has been undergoing a profound transition in the last ten years with the increased usage in oral anti-cancer medication. Approximately 25% of all anti-cancer medication is now designed for oral use and this is likely to increase prospectively. These treatments are convenient for patients and are often preferred by them, yet there are similar safety and toxicity concerns as there are to intravenous treatment. Oral anti-cancer medications (OAMs) have the potential to alleviate capacity issues in cancer treating units as patients receive their treatment at home, however there remains a requirement for safe and efficient assessment and care. Consequently, the management of patients on OAMs is of paramount importance. The optimum setting, whether within primary or secondary care, in addition to the appropriate health care professional to carry out patient assessment and monitoring needs to be established. This paper presents a protocol for a scoping review which aims to systematically and comprehensively map the literature on the current management of adults receiving OAMs. The review will follow the published guidance to direct the various steps involved. The protocol will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) framework to ensure methodological and reporting quality. Independent full text review will be performed by two reviewers and any disagreements resolved through discussion with a third reviewer. The process will be iterative in nature. This scoping review will provide a narrative synthesis and map the literature on the management of individuals receiving OAMs. This work is an appropriate initial stage in presenting the literature to inform the subsequent steps in a multi-phased research study which aims to establish and analyse the safety and efficacy of an integrated care model for the management of patients receiving OAM in the community by an advanced practitioner.
Herniated discs: when is surgery necessary?
Authors: Yoon Wai Weng , Koch Jonathan 
Published: June 2021

In all levels of disc herniations the absolute surgical indications include deteriorating neurological deficits with myelopathy or cauda equina syndrome. However, this review summarized the relative indications for surgery in each level. In cervical disc herniation (CDH), the indications for surgery consist of six months of persisting symptoms, not responding to conservative treatment. However, high-quality studies are lacking, and a randomized controlled trial is now underway to clarify the indications. In thoracic disc herniation (TDH), the indications for surgery comprise failure of conservative measures and/or worsening neurological symptoms. Moreover, giant calcified thoracic disc herniations or myelopathy signs on magnetic resonance imaging, even in the absence of neurological symptoms, may benefit from surgical treatment as a preventive measure. In lumbar disc herniation (LDH), the indications for surgery include imaging confirmation of LDH, consistent with clinical findings, and failure to improve after six weeks of conservative care. Cite this article: EFORT Open Rev 2021;6:526-530. DOI: 10.1302/2058-5241.6.210020
Analysis of the Exeter V40 femoral stem prosthesis fracture
Authors: Thompson Joshua W. , Corbett James , Bye Daniel , Jones Adrian , Tissingh Elizabeth K. , Nolan John 
Published: June 2021

Aims The Exeter V40 cemented polished tapered stem system has demonstrated excellent long-term outcomes. This paper presents a systematic review of the existing literature and reports on a large case series comparing implant fractures between the Exeter V40 series; 125 mm and conventional length stem systems. Methods A systematic literature search was performed adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. In parallel, we performed a retrospective single centre study of Exeter V40 femoral stem prosthetic fractures between April 2003 and June 2020. Results There are 25 reported cases of such prosthetic fractures confined to small case series and case reports within the literature. We report an additional 19 cases to the literature (mean age 66.3 years (SD 11.7); 12 (63%) females; BMI 32.9 kg/m2 (SD 5.9)). The mean time from index procedure to fracture was 7.8 years (SD 3.6; 2.5 to 16.3). Exeter V40 stem fracture incidence was 0.15% and 1.21% for primary and revision arthroplasty, respectively. Incidence was significantly higher in revision arthroplasty (p < 0.001) and 125 mm length stems compared to ≥ 150 mm length stems (1.25% vs 0.13%, respectively; p < 0.001). When comparing different stem length cohorts, 125 mm short-stems were associated with stem-body fractures (92% vs 29%; p = 0.0095), earlier time to fracture (6.2 years vs 11.0 years; p = 0.0018), younger patient age at time of fracture (62.7 years vs 72.6 years; p = 0.037), and female sex (75% vs 43%; p = 0.326). Conclusion This complication remains rare, although we report a significantly higher incidence at up to 17 years follow-up than in the literature. Short 125 mm length Exeter V40 stems undoubtedly have a role in restoring anatomy and biomechanics in smaller femoral geometries, although the surgeon has to appreciate the higher risk of stem fracture and the associated predisposing factors which may necessitate particular attention to surgical technique and planning. Cite this article: Bone Jt Open 2021;2(6):443–456.
Distributed feedback lasers using surface gratings in Bragg waveguides
Authors: Janjua Bilal , Iu Meng Lon , Yan Zhizhong , Charles Paul , Chen Eric , Helmy Amr S. 
Published: June 2021

This Letter presents, to the best of our knowledge, the first report of a narrow-linewidth

∼

790

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800

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m

edge-emitting semiconductor distributed feedback Bragg reflection waveguide diode laser (

D
F
B

2

R
L

). The

D
F
B

2

R
L
s

were fabricated using a ridge waveguide structure with 5th order, surface-etched grating forming the wavelength selective element. Unbonded devices with a 500 µm cavity length exhibited continuous wave threshold currents in the region of 25 mA with an output power of 2.5 mW per (uncoated) facet at 100 mA drive current. The devices operated in a single longitudinal mode, with side-mode suppression ratio (SMSR) as high as 49 dB and linewidths as low as 207 kHz. Devices maintained single mode operation with high SMSR over a 9 nm wavelength range as the temperature was swept from 15°C to 50°C.
Use of vector control to protect people from sleeping sickness in the focus of Bonon (Côte d’Ivoire)
Authors: Kaba Dramane , Djohan Vincent , Berté Djakaridja , TA Bi Tra Dieudonné , Selby Richard , Kouadio Koffi Alain De Marie , Coulibaly Bamoro , Traoré Gabehonron , Rayaisse Jean-Baptiste , Fauret Pierre , Jamonneau Vincent , Lingue Kouakou , Solano Phillipe , Torr Steve J. , Courtin Fabrice 
Published: June 2021

Background
Gambian human African trypanosomiasis (gHAT) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by tsetse flies (Glossina). In Côte d’Ivoire, Bonon is the most important focus of gHAT, with 325 cases diagnosed from 2000 to 2015 and efforts against gHAT have relied largely on mass screening and treatment of human cases. We assessed whether the addition of tsetse control by deploying Tiny Targets offers benefit to sole reliance on the screen-and-treat strategy.

Methodology and principal findings
In 2015, we performed a census of the human population of the Bonon focus, followed by an exhaustive entomological survey at 278 sites. After a public sensitization campaign, ~2000 Tiny Targets were deployed across an area of 130 km2 in February of 2016, deployment was repeated annually in the same month of 2017 and 2018. The intervention’s impact on tsetse was evaluated using a network of 30 traps which were operated for 48 hours at three-month intervals from March 2016 to December 2018. A second comprehensive entomological survey was performed in December 2018 with traps deployed at 274 of the sites used in 2015. Sub-samples of tsetse were dissected and examined microscopically for presence of trypanosomes. The census recorded 26,697 inhabitants residing in 331 settlements. Prior to the deployment of targets, the mean catch of tsetse from the 30 monitoring traps was 12.75 tsetse/trap (5.047–32.203, 95%CI), i.e. 6.4 tsetse/trap/day. Following the deployment of Tiny Targets, mean catches ranged between 0.06 (0.016–0.260, 95%CI) and 0.55 (0.166–1.794, 95%CI) tsetse/trap, i.e. 0.03–0.28 tsetse/trap/day. During the final extensive survey performed in December 2018, 52 tsetse were caught compared to 1,909 in 2015, with 11.6% (5/43) and 23.1% (101/437) infected with Trypanosoma respectively.

Conclusions
The annual deployment of Tiny Targets in the gHAT focus of Bonon reduced the density of Glossina palpalis palpalis by >95%. Tiny Targets offer a powerful addition to current strategies towards eliminating gHAT from Côte d’Ivoire.
The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
Authors: Graham Andrew D. , Lin Meng C. 
Published: June 2021

Purpose
To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye.

Methods
667 records met inclusion criteria and were extracted from a soft contact lens multi-study database. Multivariable linear mixed effects models were fit to examine the association between pre-corneal and pre-lens TFS, adjusting for potential confounders and accounting for repeated measures. Receiver Operating Characteristic (ROC) analysis was employed to assess the predictive performance of pre-corneal TFS for subsequent pre-lens TFS. TFS was quantified for this analysis as the non-invasive tear breakup time (NITBUT).

Results
Pre-corneal NITBUT was significantly related to the pre-lens NITBUT at both 10 min (p<0.001) and 2–6 hrs (p<0.001) post-lens insertion. However, the sensitivities of pre-corneal NITBUT for predicting symptom-associated thresholds of pre-lens NITBUT ranged from 50–65%, and specificities ranged from 57–72%, suggesting poor-to-moderate diagnostic performance.

Conclusions
Despite the association of pre-corneal and pre-lens TFS, the inherent lability and sensitivity to environmental exposures of the tear film introduce significant variability into NITBUT measurements. Using pre-corneal NITBUT to identify likely successful contact lens candidates prior to fitting is thus not sufficiently accurate to be relied upon in the clinical setting.
Coping strategies adapted by Ghanaians during the COVID-19 crisis and lockdown: A population-based study
Authors: Iddi Samuel , Obiri-Yeboah Dorcas , Aboh Irene Korkoi , Quansah Reginald , Owusu Samuel Asiedu , Enyan Nancy Innocentia Ebu , Kodom Ruby Victoria , Nsabimana Epaphrodite , Jansen Stefan , Ekumah Benard , Boamah Sheila A. , Boateng Godfred Odei , Doku David Teye , Armah Frederick Ato 
Published: June 2021

BackgroundThe COVID-19 pandemic and control measures adopted by countries globally can lead to stress and anxiety. Investigating the coping strategies to this unprecedented crisis is essential to guide mental health intervention and public health policy. This study examined how people are coping with the COVID-19 crisis in Ghana and identify factors influencing it.MethodsThis study was part of a multinational online cross-sectional survey on Personal and Family Coping with COVID-19 in the Global South. The study population included adults, ≥18 years and residents in Ghana. Respondents were recruited through different platforms, including social media and phone calls. The questionnaire was composed of different psychometrically validated instruments with coping as the outcome variable measured on the ordinal scale with 3 levels, namely, Not well or worse, Neutral, and Well or better. An ordinal logistic regression model using proportional odds assumption was then applied.ResultsA total of 811 responses were included in the analysis with 45.2% describing their coping level as well/better, 42.4% as neither worse nor better and 12.4% as worse/not well. Many respondents (46.9%) were between 25–34 years, 50.1% were males while 79.2% lived in urban Ghana. Having pre-existing conditions increased the chances of not coping well (aOR = 1.86, 95%CI: 1.15–3.01). Not being concerned about supporting the family financially (aOR = 1.67, 95%CI: 1.06–2.68) or having the feeling that life is better during the pandemic (aOR = 2.37, 95%CI: 1.26–4.62) increased chances of coping well. Praying (aOR: 0.62, 95%CI: 0.43–0.90) or sleeping (aOR: 0.55, 95%CI: 0.34–0.89) more during the pandemic than before reduces coping.ConclusionIn Ghana, during the COVID-19 pandemic, financial security and optimism about the disease increase one’s chances of coping well while having pre-existing medical conditions, praying and sleeping more during the pandemic than before reduces one’s chances of coping well. These findings should be considered in planning mental health and public health intervention/policy.
Predictors of mortality in patients with drug-resistant tuberculosis: A systematic review and meta-analysis
Authors: Alemu Ayinalem , Bitew Zebenay Workneh , Worku Teshager , Gamtesa Dinka Fikadu , Alebel Animut 
Published: June 2021

BackgroundEven though the lives of millions have been saved in the past decades, the mortality rate in patients with drug-resistant tuberculosis is still high. Different factors are associated with this mortality. However, there is no comprehensive global report addressing these risk factors. This study aimed to determine the predictors of mortality using data generated at the global level.MethodsWe systematically searched five electronic major databases (PubMed/Medline, CINAHL, EMBASE, Scopus, Web of Science), and other sources (Google Scholar, Google). We used the Joanna Briggs Institute Critical Appraisal tools to assess the quality of included articles. Heterogeneity assessment was conducted using the forest plot and I2heterogeneity test. Data were analyzed using STATA Version 15. The pooled hazard ratio, risk ratio, and odd’s ratio were estimated along with their 95% CIs.ResultAfter reviewing 640 articles, 49 studies met the inclusion criteria and were included in the final analysis. The predictors of mortality were; being male (HR = 1.25,95%CI;1.08,1.41,I2;30.5%), older age (HR = 2.13, 95%CI;1.64,2.62,I2;59.0%,RR = 1.40,95%CI; 1.26, 1.53, I2; 48.4%) including a 1 year increase in age (HR = 1.01, 95%CI;1.00,1.03,I2;73.0%), undernutrition (HR = 1.62,95%CI;1.28,1.97,I2;87.2%, RR = 3.13, 95% CI; 2.17,4.09, I2;0.0%), presence of any type of co-morbidity (HR = 1.92,95%CI;1.50–2.33,I2;61.4%, RR = 1.61, 95%CI;1.29, 1.93,I2;0.0%), having diabetes (HR = 1.74, 95%CI; 1.24,2.24, I2;37.3%, RR = 1.60, 95%CI;1.13,2.07, I2;0.0%), HIV co-infection (HR = 2.15, 95%CI;1.69,2.61, I2; 48.2%, RR = 1.49, 95%CI;1.27,1.72, I2;19.5%), TB history (HR = 1.30,95%CI;1.06,1.54, I2;64.6%), previous second-line anti-TB treatment (HR = 2.52, 95% CI;2.15,2.88, I2;0.0%), being smear positive at the baseline (HR = 1.45, 95%CI;1.14,1.76, I2;49.2%, RR = 1.58,95%CI;1.46,1.69, I2;48.7%), having XDR-TB (HR = 2.01, 95%CI;1.50,2.52, I2;60.8%, RR = 2.44, 95%CI;2.16,2.73,I2;46.1%), and any type of clinical complication (HR = 2.98, 95%CI; 2.32, 3.64, I2; 69.9%). There are differences and overlaps of predictors of mortality across different drug-resistance categories. The common predictors of mortality among different drug-resistance categories include; older age, presence of any type of co-morbidity, and undernutrition.ConclusionDifferent patient-related demographic (male sex, older age), and clinical factors (undernutrition, HIV co-infection, co-morbidity, diabetes, clinical complications, TB history, previous second-line anti-TB treatment, smear-positive TB, and XDR-TB) were the predictors of mortality in patients with drug-resistant tuberculosis. The findings would be an important input to the global community to take important measures.
Is stem cell transplantation still needed for adult Philadelphia chromosome-positive acute lymphoblastic leukemia receiving tyrosine kinase inhibitors therapy?: A systematic review and meta-analysis
Authors: Ponvilawan Ben , Kungwankiattichai Smith , Charoenngam Nipith , Owattanapanich Weerapat 
Published: June 2021

Background
Hematopoietic stem cell transplantation (HSCT) is the current mainstay treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). However, tyrosine kinase inhibitors (TKI) also play a significant role in the treatment of these patients. We conducted this systematic review and meta-analysis to compare the efficacy of allogeneic (allo-) HSCT, autologous (auto-) HSCT, and chemotherapy (CMT) alone–all in combination with TKIs in adult Ph+ ALL patients.

Materials and methods
This systematic review identified studies from the EMBASE and MEDLINE databases from inception to April 2021 using search terms related to “ALL” and “HSCT.” Eligible studies could be randomized controlled trials or cohort studies that included adult Ph+ ALL patients who received a TKI and either allo-HSCT, auto-HSCT, or CMT alone, and that reported the number of patients in each group for each of our primary outcomes of interest: overall survival (OS) or disease-free survival (DFS). Point estimates and associated 95% confidence intervals (CI) from each study were combined using the Hantel-Maenszel method.

Results
After two rounds of review, 26 cohort studies were determined to be eligible for the meta-analysis. Adult Ph+ ALL patients who received HSCT had better survival outcomes than those who did not receive any HSCT (pooled odds ratio [OR] for OS of 1.61, 95%CI: 1.08–2.40; I2 = 59%, and for DFS of 3.23, 95%CI: 2.00–5.23; I2 = 62% for allo-HSCT; and, pooled OR for OS of 7.04, 95%CI: 1.97–25.15; I2 = 0%, and for DFS of 5.78, 95%CI: 1.04–32.19; I2 = 42% for auto-HSCT). Allo-HSCT recipients had comparable OS and DFS, but lower relapse rate compared to auto-HSCT recipients. Funnel plot generally demonstrated no presence of publication bias.

Conclusions
This systematic review and meta-analysis demonstrated superior results of HSCT in Ph+ ALL patients compared to CMT alone. Moreover, auto-HSCT could be implemented with comparable survival outcomes to allo-HSCT in patients with no available donor or when haploidentical HSCT is not feasible.
Temperature dependence of hardness prediction for high-temperature structural ceramics and their composites
Authors: Wang Ruzhuan , Li Dingyu , Li Weiguo 
Published: June 2021

Abstract
Hardness is one of the important mechanical properties of high-temperature structural ceramics and their composites. In spite of the extensive use of the materials in high-temperature applications, there are few theoretical models for analyzing their temperature-dependent hardness. To fill this gap in the available literature, this work is focused on developing novel theoretical models for the temperature dependence of the hardness of the ceramics and their composites. The proposed model is just expressed in terms of some basic material parameters including Young’s modulus, melting points, and critical damage size corresponding to plastic deformation, which has no fitting parameters, thereby being simple for materials scientists and engineers to use in the material design. The model predictions for the temperature dependence of hardness of some oxide ceramics, non-oxide ceramics, ceramic–ceramic composites, diamond–ceramic composites, and ceramic-based cermet are presented, and excellent agreements with the experimental measurements are shown. Compared with the experimental measurements, the developed model can effectively save the cost when applied in the material design, which could be used to predict at any targeted temperature. Furthermore, the models could be used to determine the underlying control mechanisms of the temperature dependence of the hardness of the materials.
Skeuomorphism in Digital Archeological Practice: A Barrier to Progress, or a Vital Cog in the Wheels of Change?
Authors: Taylor James , Dell’Unto Nicoló 
Published: June 2021

Abstract
This article focuses on the role of “skeuomorphic technologies” and “skeuomorphs of practice” in the development of digital workflows in archeology, seeking to examine whether there are common trends toward skeuomorphism in our development of digital infrastructures. By considering the way in which GIS, tablet, and 3D technologies were integrated into the digital field recording at the sites of Çatalhöyük in Turkey and Kämpinge in Sweden, we argue that skeuomorphic emulation may form an essential part of the process of “controlling” “socializing” new digital technologies and ultimately transforming digital practice. Ultimately we contend that a field approach that explicitly takes into account skeuomorphism as a crucial element of transformation is more likely to encourage the development of practices, which go behind the traditional investigation paradigms. Understanding the role of skeuomorphism as a mode of socializing technology (see below) within the broader framework of the development of digital field practices can help us to critically address the process of transformation of practice and identify new methodological directions.
A facile route to dual-crosslinking polymeric hydrogels with enhanced mechanical property
Authors: Xue Shishan , Ye Zhiyong , Tang Qiao , Wang Yu 
Published: June 2021

Abstract
Polymeric hydrogels with excellent biocompatibility, high hydrophilicity, and water-holding capacity have attracted considerable concerns in widely fields. However, most hydrogels exhibit poor mechanical property, which largely limited their applications. Herein, a novel dual-crosslinking polymeric hydrogel crosslinked by covalent bonds and metal coordination interactions between Fe3+ and –COO- was fabricated through accessible method. The metal coordination interactions within the hydrogel were established through dipping in the FeCl3 solution to reinforce the backbones of the hydrogel. The obtained polymeric hydrogel exhibits enhanced tensile strength (∼4.92 MPa), stiffness (∼6.168 MPa), and toughness (∼2.835 MJ m−3).