bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid mechanics of the left atrial ligation chick embryonic model of hypoplastic left heart syndrome
Authors: Ho Sheldon , Chan Wei Xuan , Yap Choon Hwai 
Published: March 2021

AbstractLeft atrial ligation (LAL) of the chick embryonic heart at HH21 is a model of the hypoplastic left heart syndrome (HLHS) disease, demonstrating morphological and hemodynamic features similar to human HLHS cases. Since it relies on mechanical intervention without genetic or pharmacological manipulations, it is a good model for understanding the biomechanics origins of such HLHS malformations. To date, however, the fluid mechanical environment of this model is poorly understood. In the current study, we performed 4D ultrasound imaging of LAL and normal chick embryonic hearts and 4D cardiac flow simulations to help shed light on the mechanical environment that may lead to the HLHS morphology. Results showed that the HH25 LAL atrial function was compromised, and velocities in the ventricle were reduced. The HH25 LAL ventricles developed a more triangular shape with a sharper apex, and in some cases, the atrioventricular junction shifted medially. These changes led to more sluggish flow near the ventricular free wall and apex, where more fluid particles moved in an oscillatory manner with the motion of the ventricular wall, while slowly being washed out, resulting in lower wall shear stresses and higher oscillatory indices. Consequent to these flow conditions, at HH28, even before septation is complete, the left ventricle was found to be hypoplastic while the right ventricle was found to be larger in compensation. Our results suggest that the low and oscillatory flow near the left side of the heart may play a role in causing the HLHS morphology in the LAL model.
Lower temperature influences Cauliflower mosaic virus systemic infection
Authors: Alers-Velazquez Roberto , Khandekar Sushant , Muller Clare , Boldt Jennifer , Leisner Scott 
Published: March 2021

AbstractLower temperatures delayed development of systemic symptoms by Cauliflower mosaic virus (CaMV) in two different plant hosts. However, lower temperature exposure increased CaMV nucleic acid levels in leaves of systemically-infected turnips. Furthermore, lower temperature altered the formation of aggregates formed by the CaMV major inclusion body (IB) protein, P6. Finally, lower temperature altered the architecture of the actin cytoskeleton. These data may suggest that lower temperatures alter the actin cytoskeleton, facilitating the formation of larger IBs that hold on to their internal virions more strongly than small ones, impairing virus particle release and causing a delay in systemic infection.
Associations between social burden, perceived stress, and diurnal cortisol profiles in older adults: implications for cognitive aging
Authors: Pretscher Anna , Kauzner Saskia , Rohleder Nicolas , Becker Linda 
Published: March 2021

AbstractStress can be a risk factor for mental and physical health. We investigated the role of social burden as a potential stressor in older age and its associations with cognitive aging (i.e., within the domains inhibition and cognitive flexibility of executive functioning). Eighty-three older adults (N = 38 male, mean age = 74.0 ± 5.7 years, body-mass index = 25.5 ± 4.1 kg/m2) aged 64 years or older participated. Cognitive flexibility and inhibition were assessed by means of a Trail-Making Test (TMT) and a Stroop task. Perceived levels of social burden and perceived stress in general were assessed via standardized questionnaires. Furthermore, diurnal cortisol profiles were assessed. Overall, older participants showed lower cognitive performance than the younger (both inhibition and cognitive flexibility; p < .044). However, this association did not remain significant when adjusting for multiple comparisons. Social burden was highly correlated with perceived stress, highlighting its importance as a stressor (p < .001). Furthermore, participants who reported higher levels of perceived stress showed lower performance in the TMT as a measure for cognitive flexibility (p < .001). Moreover, social burden was associated with cognitive flexibility, which was assessed by means of the TMT (p = .031). However, this association did not remain significant when using the adjusted α-level. Furthermore, we found that total diurnal cortisol output was a mediator for the relationship between age and inhibition, which was assessed by means of a Stroop task. At last, we found that the mediating role of cortisol interacts with social burden in the way that especially in younger age, high levels of social burden are associated with higher cortisol levels and, therefore, with lower cognitive performance. We conclude that it is important to consider social burden as an additional stressor in older age which is associated with cognitive aging.
Transformative Readings: Harry Potter Fan Fiction, Trans/Queer Reader Response, and J. K. Rowling
Authors: Duggan Jennifer 
Published: March 2021

AbstractThe politics of children’s literature and the actors surrounding it have never been more visible than they are now, in the digital age. As one of the first children’s series to gain widespread popularity concurrently with the spread of the internet, the Harry Potter septet arrived on the global stage at the perfect moment to develop an avid, connected fandom. But the fandom has laid bare the many conflicting ideologies of the fans themselves and of the actors surrounding the texts. This article examines the contentious issue of gender nonnormativity and its relation to the Harry Potter texts, the queer/trans reading practices and political resistance common to the fandom, and the ongoing disagreements over gender, made visible on social media, between Rowling and the fans of her series. The article discusses the Harry Potter novels’ varied and conflicting ideologies; queer/trans readings of the Potter septet, including both invitations and resistances to queer/trans reading by Rowling herself; how gender is queered and queried in and through fan fiction; and finally, the recent hostilities between Rowling and her fans. It concludes by discussing the worsening relationship between Rowling and her fans and highlighting how fans are using their collective power to undermine Rowling’s gender politics through fan fiction. By doing so, the article traces the complex politics of the reception of books for young people in the digital age, demonstrating that authors’ powerful voices continue to shape readers’ responses to texts long after their publication but showing, too, that readers often resist authors’ attempts to influence not only their textual interpretations but their politics.
Genotyping by Multiplexed Sequencing (GMS) protocol in Barley
Authors: Eagle Jonathan , Ruff Travis , Hooker Marcus , Sthapit Sajal , Marston Elliott , Marlowe Karol , Covarrubias Dolores , Skinner Daniel , Hayes Patrick , Sherman Jamie , See Deven 
Published: April 2021

AbstractGenotyping by sequencing (GBS) and single nucleotide polymorphism (SNP) chip technologies are the primary SNP genotyping technologies used today. However, these genotyping technologies have some drawbacks that limit their usefulness in analysis. We have developed a robust protocol called genotyping by multiplexed sequencing (GMS) using SNP markers, providing informative genotypic data with greater flexibility. The genotypes derived from direct sequence reads reduce ambiguity in genetic analysis. The advantages of this protocol include: (1) This PCR-based direct sequencing protocol generates information from markers of interest and provides a more streamlined and accurate analysis process, by multiplexing hundreds of informative markers into a single sequencing run. (2) The marker sets are easily customized to the species of interest and can readily be changed. In this study we have taken the GMS protocol developed in wheat and adapted it to barley. We have identified 577 SNP markers that work well using this protocol providing adequate genome coverage for genomic selection and tag 267 QTL’s for genes of interest. Good markers have an adequate read depth of at least 5 amplicons and are reliably present across the population.
Empirical Estimation of Uniaxial Compressive Strength of Rock: Database of Simple, Multiple, and Artificial Intelligence-Based Regressions
Authors: Aladejare Adeyemi Emman , Alofe Emmanuel Damola , Onifade Moshood , Lawal Abiodun Ismail , Ozoji Toochukwu Malachi , Zhang Zong-Xian 
Published: April 2021

AbstractEmpirical relationships for estimating Uniaxial Compressive Strength (UCS) of rock from other rock properties are numerous in literature. This is because the laboratory procedure for determination of UCS from compression tests is cumbersome, time consuming, and often considered expensive, especially for small to medium-sized mining engineering projects. However, these empirical models are scattered in literature, making it difficult to access a considerable number of them when there is need to select empirical model for estimation of UCS. This often leads to bias in estimated UCS data as there may be underestimation or overestimation of UCS, because of the site-specific nature of rock properties. Therefore, this study develops large database of empirical relationships between UCS and other rock properties that are reported in literatures. Statistical analysis was performed on the regression equations in the database developed. The typical ranges and mean of data used in developing the regressions, and the range and mean of their R2values were evaluated and summarised. Most of the regression equations were found to be developed from reasonable quantity of data with moderate to high R2values. The database can be easily assessed to select appropriate regression equation when there is need to estimate UCS for a specific site.
Laboratory Experiments and Grain Based Discrete Element Numerical Simulations Investigating the Thermo-Mechanical Behaviour of Sandstone
Authors: Woodman James , Ougier-Simonin Audrey , Stavrou Anastasios , Vazaios Ioannis , Murphy William , Thomas Mark E. , Reeves Helen J. 
Published: April 2021

AbstractThermo-mechanical loading can occur in numerous engineering geological environments, from both natural and anthropogenic sources. Different minerals and micro-defects in rock cause heterogeneity at a grain scale, affecting the mechanical and thermal properties of the material. Changes in strength and stiffness can occur from exposure to elevated temperatures, with the accumulation of localised stresses resulting in thermally induced micro-cracking within the rock. In this study we investigated thermal micro-cracking at a grain scale through both laboratory experiments and their numerical simulations. We performed laboratory triaxial experiments on specimens of fine-grained sandstone at a confining pressure of 5 MPa and room temperature (20$$^{\circ }\hbox {C}$$

∘

C

), as well as heating to 50$$^{\circ }\hbox {C}$$

∘

C

, 75$$^{\circ }\hbox {C}$$

∘

C

and 100$$^{\circ }\hbox {C}$$

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C

prior to mechanical loading. The laboratory experiments were then replicated using discrete element method simulations. The geometry and granular structure of the sandstone was replicated using a Voronoi tessellation scheme to produce a grain based model. Strength and stiffness properties of the Voronoi contacts were calibrated to the laboratory specimens. Grain scale thermal properties were applied to the grain based models according to mineral percentages obtained from quantitative X-ray diffraction analysis on laboratory specimens. Thermo-mechanically coupled modelling was then undertaken to reproduce the thermal loading rates used in the laboratory, before applying a mechanical load in the models until failure. Laboratory results show a reduction of up to 15% peak strength with increasing thermal loading between room temperature and 100$$^{\circ }\hbox {C}$$

∘

C

, and micro-structural analysis shows the development of thermally induced micro-cracking in laboratory specimens. The mechanical numerical simulations calibrate well with the laboratory results, and introducing coupled thermal loading to the simulations shows the development of localised stresses within the models, leading to the formation of thermally induced micro-cracks and strength reduction upon mechanical loading.
The concept of disease in the time of COVID-19
Authors: Amoretti Maria Cristina , Lalumera Elisabetta 
Published: April 2021

AbstractPhilosophers of medicine have formulated different accounts of the concept of disease. Which concept of disease one assumes has implications for what conditions count as diseases and, by extension, who may be regarded as having a disease (disease judgements) and for who may be accorded the social privileges and personal responsibilities associated with being sick (sickness judgements). In this article, we consider an ideal diagnostic test for coronavirus disease 2019 (COVID-19) infection with respect to four groups of people—positive and asymptomatic; positive and symptomatic; negative; and untested—and show how different concepts of disease impact on the disease and sickness judgements for these groups. The suggestion is that sickness judgements and social measures akin to those experienced during the current COVID-19 outbreak presuppose a concept of disease containing social (risk of) harm as a component. We indicate the problems that arise when adopting this kind of disease concept beyond a state of emergency.
Multi-objective approaches to ground station scheduling for optimization of communication with satellites
Authors: Petelin Gašper , Antoniou Margarita , Papa Gregor 
Published: March 2021

AbstractThe ground station scheduling problem is a complex scheduling problem involving multiple objectives. Evolutionary techniques for multi-objective optimization are becoming popular among different fields, due to their effectiveness in obtaining a set of trade-off solutions. In contrast to some conventional methods, that aggregate the objectives into one weighted-sum objective function, multi-objective evolutionary algorithms manage to find a set of solutions in the Pareto-optimal front. Selecting one algorithm, however, for a specific problem adds additional challenge. In this paper the ground station scheduling problem was solved through six different evolutionary multi-objective algorithms, the NSGA-II, NSGA-III, SPEA2, GDE3, IBEA, and MOEA/D. The goal is to test their efficacy and performance to a number of benchmark static instances of the ground scheduling problem. Benchmark instances are of different sizes, allowing further testing of the behavior of the algorithms to different dimensionality of the problem. The solutions are compared to the recent solutions of a weighted-sum approach solved by the GA. The results show that all multi-objective algorithms manage to find as good solution as the weighted-sum, while giving more additional alternatives. The decomposition-based MOEA/D outperforms the rest of the algorithms for the specific problem in almost all aspects.
Mental imagery: pulling the plug on perceptualism
Authors: Cavedon-Taylor Dan 
Published: March 2021

AbstractWhat is the relationship between perception and mental imagery? I aim to eliminate an answer that I call perceptualism about mental imagery. Strong perceptualism, defended by Bence Nanay, predictive processing theorists, and several others, claims that imagery is a kind of perceptual state. Weak perceptualism, defended by M. G. F. Martin and Matthew Soteriou, claims that mental imagery is a representation of a perceptual state, a view sometimes called The Dependency Thesis. Strong perceptualism is to be rejected since it misclassifies imagery disorders and abnormalities as perceptual disorders and abnormalities. Weak Perceptualism is to be rejected since it gets wrong the aim and accuracy conditions of a whole class of mental imagery–projected mental imagery–and relies on an impoverished concept of perceptual states, ignoring certain of their structural features. Whatever the relationship between perception and imagery, the perceptualist has it wrong.
Flourishing with Shared Vitality: Education based on Aesthetic Experience, with Performance for Meaning
Authors: Doddington Christine 
Published: March 2021

AbstractIn this paper, I set an aspect of what it is to live a flourishing life against the backdrop of neo liberal trends that continue to influence educational policy across the globe. The view I set out is in sharp contrast to any narrow assumption that education’s main task is the measurement of high performing individuals who will thus contribute to an economically viable society. Instead, I explore and argue for a conception of what constitutes a flourishing life that is embedded in a more pragmatist analysis of what education may be. The argument begins with developing the centrality of embodiment to aesthetic sensibility and goes on to suggest how collective understanding of this within a community could constitute a sense of performance and thus contribute to the educational aim of developing a full and flourishing life. The argument is that this way of seeing life could have implications for educational practice, the role of the teacher and could help to reconfigure how education is experienced by the young.
Endangered lowland oak forest steppe remnants keep unique bird species richness in Central Hungary
Authors: Ónodi Gábor , Botta-Dukát Zoltán , Winkler Dániel , Rédei Tamás 
Published: March 2021

AbstractThe biodiversity of natural or semi-natural native, old oak woodlands have high conservation importance, especially in landscapes of monocultural forest plantations and arable fields. With a wider variety of microhabitats and foraging sources, such old oak forests can provide essential habitat for native forest bird communities. We conducted a study using bird point counts to compare the forest bird communities of old pedunculate oak (Quercus robur) remnants with native and non-native plantations in central Hungary in a landscape of mostly arable fields, settlements, and monocultural plantations. Avian surveys were carried out in old oak forest remnants, middle-aged oak, white poplar (Populus alba), hybrid poplar (Populus × euramericana), black locust (Robinia pseudoacacia), and pine (Pinusspp.) plantations. Fieldwork has been carried out in nine study sites, where all six habitat types were represented (with a few exceptions), to determine total abundance, species richness, Shannon–Wiener diversity, species evenness, dominant and indicator species, and guild abundances. We found that old oak forest remnants were the most diverse habitats among the studied forest types, while hybrid poplar and pine plantations exhibited the lowest avian biodiversity. The avian guilds most sensitive to the loss of old oak forest remnants were ground foragers, bark foragers, cavity-nesters, residents, and Mediterranean migratory birds. Native habitats were more diverse than non-native plantations. Our results suggest that it is important to conserve all remaining high biodiversity old oak stands and to avoid clear-cutting of monocultural plantations in favour of practices such as mixed-species plantations, longer rotation lengths, or retention forestry.
Refugee Reception Re-examined: a Quantitative Study on the Impact of the Reception Period for Mental Health and Host Country Language Proficiency Among Syrian Refugees in the Netherlands
Authors: Damen Roxy Elisabeth Christina , Dagevos Jaco , Huijnk Willem 
Published: March 2021

AbstractIn many European countries, refugees spend their first period after arrival in the receiving country in reception centers. Though this reception period has been heavily criticized, especially in relation to mental health, few scholars examined its impact on refugee integration. Since host country language learning is the main focus for most recent arrivals, this study re-examines the impact of the (renewed) reception period on both refugee mental health and host country language proficiency. Using a unique dataset including 3209 Syrian permitholders in the Netherlands, we test a structural equation model to examine those relations directly and indirectly. Results partly replicate previous findings, showing the negative impact of the number of relocations on mental health as well as the negative impact of both length of stay and relocations on host country language proficiency. Nevertheless, we did not find support for a negative relationship between length of stay and mental health. Moreover, the image of the reception period is not as gloomy as before; activities asylum seekers can engage in during their stay is positively related to both mental health and host country language proficiency. The relationships between both relocations and activities and host country language proficiency can partially be explained by mental health. These results indicate that the reception period can be seen as both an obstacle and a facilitator. Since the context of reception is a post-migration stressor, these findings should inform receiving societies and inspire them to accommodate their refugee reception accordingly, ensuring a smooth(er) start for future refugees.
Should I Stay or Should I Go? International Students’ Decision-Making About Staying in Canada
Authors: Netierman Elena , Harrison Lauren , Freeman Angela , Shoyele Grace , Esses Victoria , Covell Christine 
Published: April 2021

AbstractRecent decades have seen an increase in the popularity of international education. Approximately 500,000 international students were in Canada in 2018 and this number is projected to grow. While we know that many international students decide to stay in Canada, we do not fully understand the decision-making process employed by international students regarding staying in Canada or going back home after completing their education. The purpose of this study was to explore how international students make decisions about their post-graduation destination and what factors they see as pivotal in shaping their decision-making process. We utilized a symbolic interactionist approach to analyze qualitative semi-structured interviews with 60 international students enrolled in post-secondary programs in Canada. Our findings suggest that the meaning students attach to staying in Canada varies from obtaining permanent residency to working for a few months upon graduation. We also demonstrate that for most students, the decision to stay in Canada is formed gradually and is shaped by familial obligations, cultural climate they experience in Canada, employment opportunities available to them upon graduation, and the possibility of obtaining permanent residency.