bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elective Percutaneous Coronary Intervention Performed During Contrast-Induced Hypotension
Authors: Soomro Armaghan Y , Almaddah Nureddin , Lendel Vasili , Agarwal Shiv Kumar , Uretsky Barry F. 
Published: June 2021

Abstract
Objectives: To demonstrate the feasibility and safety of performing percutaneous coronary intervention (PCI) during contrast reaction producing severe hypotension.Background: The development of profound hypotension due to a contrast reaction usually signals procedure termination. Methods and Results: We report successful completion of planned PCI with blood pressure support with vasopressors during contrast-induced hypotension in 9 procedures in 3 patients with previously known contrast reaction. Conclusions: This case series provides support for the feasibility and safety of performing successful planned PCI under blood pressure support in patients with contrast reaction causing severe hypotension. A management approach for considering intervention in the setting of contrast-induced hypotension is provided.
Differential Growth Rates, Rather Than Compaction, Determine Left Ventricular Wall Formation
Authors: Faber Jaeike , Wüst Rob , Dierx Inge , Hummelink Janneke , Kuster Diederik , Nollet Edgar , Moorman Antoon , Sánchez-Quintana Damián , Wal Allard van der , Christoffels Vincent , Jensen Bjarke 
Published: June 2021

Abstract
Trabecular muscle makes up most of the ventricular wall of the human embryo. It is presumed that compaction in the foetal period changes ventricular wall morphology by converting weaker trabeculae to stronger compact muscle. Using developmental series covering the embryonic and foetal periods of human, mouse and chicken, we show ventricular morphology is determined by differential rates of positive growth of trabecular and compact layers rather than compaction. In mouse, foetal cardiomyocytes are relative weak, but adult trabecular and compact cardiomyocytes are equally strong. In foetal and adult humans, trabecular and compact myocardium exhibit a similar abundance of immunohistochemically detected vascular, mitochondrial and sarcomeric proteins. Even in human noncompaction, a congenital malformation characterized by excessive trabeculation, the trabecular and compact muscle are similar. In conclusion, trabecular and compact myocardium are equally equipped for force production and their proportions are determined not by compaction, but by differential growth rates.
An Experimental Study on Eco-Friendly and Cost-Effective Natural Materials for Productivity Enhancemento Single Slope Solar Still
Authors: NATARAJAN SENDHIL KUMAR , Suraparaju Subbarama Kousik , Elavarasan Rajvikram Madurai , Pugazhendhi Rishi , Hossain Eklas 
Published: June 2021

Abstract
The proposed research study aims to improve the productivity of solar still (SS) by using low-cost and eco-friendly materials. The aforementioned objective was achieved by enhancing the evaporation rate of seawater in the absorber basin and the condensation rate over the glass cover of the solar still. In this study, the low-cost and eco-friendly materials used for enhancing the evaporation rate in the solar still were Molasses Powder (MP), Sawdust (SD), Rise Husk (RH). In addition to these materials, Bamboo Straw (BS), Banana Leaf stem (BL), and Rice Straw (RS) were used as absorbing materials over the glass cover for enhancing the condensation rate. The experiments were carried out under similar meteorological conditions and the results of the modified solar still were compared with Conventional Solar Still (CSS). The productivities of CSS, SSMP, SSRH, SSSD, SSBS, SSBL and SSRS were about 2250 mL/m2, 2383 mL/m2, 2467 mL/m2, 3033 mL/m2, 2700 mL/m2, 2683 mL/m2, and 3367 mL/m2 , respectively. The results of the experimental investigation highlighted that the SSSD had a comparatively better evaporation rate and 34.81% higher yield than CSS. Besides, SSRS had a comparatively better condensation rate and a 51.88% higher yield than CSS. Later, the combination of sawdust (SD) and rice straw (RS) was investigated for combined enhancement of evaporation and condensation. The solar still with sawdust and rice straw (SSSDRS) showed a 62.88% improvement in productivity with 3633 mL/m2 when compared to CSS. Also, the economic analysis showed that the cost per litre (CPL) of freshwater obtained from SSSDRS was about ₹ 1.9 ($ 0.025) with a payback period of 4.4 months which was the least when compared to all the considered cases.
Epigenetic Silencing of Tumor Suppressor lncRNA NKILA: Implication on NF-κB Signaling in Non-Hodgkin’s Lymphoma
Authors: Zhang Min Yue , Calin George , Deng Ming Dan , Au-Yeung Rex K.H. , Wang Lu Qian , Chim James 
Published: June 2021

Abstract
Background
The long non-coding RNA (lncRNA) NKILA, localized to 20q13.31, is a negative regulator of NF-κB signaling. As a CpG island is embedded in the promoter region of NKILA, NKILA is hypothesized as a tumor suppressor lncRNA reversibly silenced by promoter DNA methylation in non-Hodgkin’s lymphoma (NHL).
Methods
Methylation-specific PCR (MSP) and quantitative bisulfite pyrosequencing were performed to detect the methylation of NKILA in normal peripheral blood buffy coats, normal tonsils tissue, NHL cell lines and NHL primary samples. SU-DHL-6 cells were treated with 5-Aza-2'-deoxycytidine for reversal of methylation-associated NKILA silencing. Tumor suppressor properties and biological function of NKILA were demonstrated by knockdown of NKILA in SU-DHL-1 cells.
Results
By pyrosequencing-verified MSP, NKILA was unmethylated in normal healthy controls, including 10 peripheral blood buffy coats and 11 tonsils tissue, but completely methylated in one (10%) NHL cell line SU-DHL-6. Among the lymphoma cell lines, by semi-quantitative RT-PCR, methylation of NKILA was inversely correlated with its expression. In the completely methylated SU-DHL-6 cells, hypomethylation treatment with 5-Aza-2'-deoxycytidine resulted in promoter demethylation and re-expression of NKILA transcript. In 102 NHL primary samples, NKILA methylation was observed in none of mantle cell lymphoma (MCL) cases, but in 29 (51.79%) diffuse large-B cell lymphoma (DLBCL) and 4 (20%) peripheral T-cell lymphoma (PTCL) cases, hence preferentially methylated in DLBCL than MCL (P < 0.0001) and PTCL (P = 0.007). Mechanistically, knockdown of NKILA resulted in promoting IkBα phosphorylation associated with nucleus translocation of total p65 and phosphorylated p65 in SU-DHL-1 cells, hence constitutive NF-κB activation. Functionally, knock-down of NKILA in SU-DHL-1 cells led to decreased cell death and increased cellular proliferation, indicating a tumor suppressor role of NKILA in NHL cells.
Conclusion
NKILA is a tumour suppressor lncRNA frequently hypermethylated in DLBCL. Promoter DNA methylation-mediated NKILA silencing led to increase of cellular proliferation and decrease of cell death via repression of NF-κB signaling in NHL cells.
A Combined Experimental and Atomistic Investigation of PTFE Double Transfer Film Formation and Lubrication in Rolling Point Contacts
Authors: von Goeldel Stephan , Reichenbach Thomas , König Florian , Mayrhofer Leonhard , Moras Gianpietro , Jacobs Georg , Moseler Michael 
Published: June 2021

Abstract
Solid lubricants such as polytetrafluoroethylene (PTFE) are used in rolling-element bearings (REBs) when conventional lubrication (i.e. by fluids or greases) cannot be applied owing to extreme operating conditions (e.g. high temperatures or vacuum). Often a double transfer film mechanism is used with a cage acting as a lubricant reservoir resupplying the REB with solid lubricant by cage wear. An increase in service life of such bearings requires a better understanding of the transfer processes in the sliding and rolling contacts. Here, we investigate the effect of PTFE resupply on friction and lubricant film formation in a steel/steel and steel/glass rolling contact by tribometry and classical molecular dynamics (MD). A ball-on-disk tribometer is enhanced by a pin-on-disk sliding contact that transfers PTFE to the disk. The experiment allows simultaneous in situ measurement of friction and film thickness by white light interferometry in the rolling point contact. Increasing the pin load results in an increased PTFE film thickness in the rolling contact accompanied by a significant decrease in friction. To elucidate the observed film transfer and friction mechanism, sliding MD simulations with a newly developed density-functional-based, non-reactive force field for PTFE-lubricated iron oxide surfaces are performed. A strong adhesion of PTFE chains to iron oxide drives transfer film formation, while shear-induced chain alignment within PTFE results in reduced friction. The simulations reveal an anti-correlation between PTFE film thickness and friction coefficient – in agreement with the experiments. These investigations are a first step towards methods to control PTFE transfer film formation in REBs.
Hydrologic Similarity Based on Width Function and Hypsometry: An Unsupervised Learning Approach
Authors: Bajracharya Prashanta , Jain Shaleen 
Published: June 2021

Abstract
In ungauged or data-scarce watersheds, systematic analyses of a set of proximate watersheds (for example, selected based on locational proximity or similarity in climate, morphometry, lithology, soils, and vegetation) have been shown to lend significant insights regarding hydrologic response and prediction. Current approaches often rely on: (a) statistical regression models that use measurable watershed attributes, such as area, slope, and stream length; and (b) comparative hydrology that considers watershed characteristics to assess hydrologic similarity to select analogous gauged watersheds as proxies. Newer conceptions regarding hydrologic similarity focus on hydrologic response and therefore emphasize the use of dynamical measures of the stream network and watershed terrain. For example, the width function and hypsometric curve can be readily estimated using the available global digital terrain datasets and represented as functional forms involving a small set of parameters, thus achieving significant data reduction. In this study, a new approach to hydrological similarity in watersheds, one that utilizes these functional forms to identify dynamically similar watersheds, is presented. Dissimilarity matrices are created based on divergence measures, and watersheds are classified using hierarchical clustering. The joint analysis of watershed width functions and hypsometric curves allows for the classification of watersheds into a reduced number of dynamically-similar groups. An illustrative case study for the Narmada River, with 72 sub-watersheds, is presented.
Single emission spectrum measurement enables control of
organic LED emission zone giving ultralong device lifetime
Authors: Ciarnáin Rossa Mac , Mo Hin Wai , Nagayoshi Kaori , Fujimoto Hiroshi , Harada Kentaro , Gehlhaar Robert , Ke Tung-Huei , Heremans Paul , Adachi Chihaya 
Published: June 2021

Abstract
Device optimization of light-emitting diodes targets the most efficient conversion of electrically injected charges into emitted light. Where charges recombine and where light is emitted from is known as the emission zone. Determining its form is key to better understanding the physical processes determining device performance. However, a thorough measurement study has not been shown. Here we present an accessible technique to visualize the emission zone in unprecedented detail at all luminescing current densities. Only a single emission spectrum must be measured (at normal direction to the device layers with no additional optics) and compared with the simulated emission spectrum. This method allows physical understanding based, instead of speculative, optimisation of LED device architectures. We demonstrate its impact by examining the device structure – emission zone – lifetime relationships of a thermally activated delayed fluorescence OLED to achieve an ultralong 4500 hour T95 lifetime at 1000 cd/m2 with 20% external quantum efficiency.
Atomically engineered interfaces yield extraordinary electrostriction
Authors: Pryds Nini , Zhang Haiwu , Park Dae-Sung , Gauquelin Nicolas , Santucci Simone , Christensen Dennis , Jannis Daen , Chezganov Dmitry , Rata Diana , Castelli Ivano , Verbeeck Johan , Lubomirsky Igor , Muralt Paul , Damjanovic Dragan , Esposito Vincenzo 
Published: June 2021

Abstract
Electrostriction is a property of all the dielectric materials where an applied electric field induces a mechanical deformation proportional to the square of the electric field. The magnitude of the effect is usually minuscule. However, recent discoveries of symmetry-breaking phenomena at interfaces opens up the possibility to extend the electrostrictive response to a broader family of dielectric materials.1,2 Here, we engineer the electrostrictive effect by epitaxially depositing alternating layers of Gd2O3-doped CeO2 and Er2O3-stabilized δ-Bi2O3 with atomically controlled interfaces on NdGaO3 substrates. We find that the electrostriction coefficient reaches 2.38×10-14 m2/V2, exceeding the best-known relaxor ferroelectrics by three orders of magnitude. Our atomic-scale calculations show that the extraordinary electrostriction coefficient is driven by the coherent strain imparted by the interfacial lattice mismatches. Thus, artificial heterostructures open a new avenue to design and manipulate electrostrictive materials and devices for nano/micro actuation and cutting-edge sensor applications.
Prediction of Nickel Concentrations in Urban and Peri-Urban Soils: Application of a Hybridized Empirical Bayesian Kriging and Support Vector Machine Regression Approach
Authors: Agyeman Prince Chapman , Kebonye Ndiye Michael , JOHN Kingsley 
Published: June 2021

Abstract
Soil pollution is a big issue caused by anthropogenic activities. The spatial distribution of potentially toxic elements (PTEs) varies in most urban and peri-urban areas. As a result, spatially predicting the PTEs content in such soil is difficult. A total number of 115 samples were obtained from Frydek Mistek in the Czech Republic. Calcium(Ca), magnesium(Mg), potassium(K), and nickel (Ni) concentrations were determined using Inductively Coupled Plasma Optical Emission Spectroscopy. The correlation matrix between the response variable and the predictors revealed a satisfactory correlation between the elements. The prediction results indicated that support vector machine regression (SVMR) performed well although its estimated root mean square error (RMSE) (235.974) and mean absolute error (MAE) (166.946) were higher when compared with the other methods applied. Conversely, the hybridized model of empirical bayesian kriging -multiple linear regression (EBK-MLR) performed poorly as indicated by the measured coefficient of determination value below 0.1. The empirical bayesian kriging-support vector machine regression (EBK-SVMR) model was the best model, with low RMSE (95.479) and MAE (77.368) values and a high coefficient of determination (R2 = 0.637). EBK-SVMR modeling technique was visualized using self-organizing map. The clustered neurons of the hybridized model CakMg -EBK-SVMR component plane showed a diverse color pattern predicting the concentration of Ni in the urban and peri urban soil. The results proved that combining EBK and SVMR is an effective technique for predicting Ni concentrations in urban and peri-urban soil.
Ferroptosis inhibitor alleviates cytotoxicity induced by cobalt nanoparticles through reactive oxygen species attenuation
Authors: Wang Chen , Zhang Weinan , Liu Fan , Liu Yake 
Published: June 2021

Abstract
Background Currently, tissue damage induced by cobalt nanoparticles (CoNPs) are the most noticeable adverse effect in the patients with metal-on-metal (MOM) hip prostheses. Therefore, effective therapeutic strategy is needed to limit the toxicity of CoNPs. In this study, we aimed to investigate the protective effect of ferroptosis inhibitor on CoNPs-induced cytotoxicity. Methods To evaluate the detoxification effect of ferroptosis inhibitor, MG-63 cells were treated with CoNPs and ferroptosis inhibitor for 24 h. The cell viabilities were measured by CCK-8 assay. The expressions of glutathione peroxidase 4(GPX4) and solute carrier family 7 member 11(SLC7A11) were examined by western blot. Reactive oxygen species (ROS) and the GSH level were measured by the relevant kits. The cell apoptosis was detected by flow cytometry. The serum levels of inflammatory cytokines were measured with Elisa.Results The cytotoxic effects of CoNPs were time- and dose-dependent. In addition, CoNPs elicited a significant (p <0.05) reduction in cell viability and the glutathione (GSH) level with a concomitant increase in ROS generation and inflammatory cytokines such as tumour necrosis factor α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) after 24 hours of exposure. Deferiprone (DFP) provided significant protection for cells after treatment with CoNPs. Western blot analysis demonstrated that CoNPs decreased the expression of GPX4 and SLC7A11, and treatment with DFP inhibited the decrease.Conclusions CoNPs were highly cytotoxic and ferroptosis inhibitor DFP has a detoxification effect on cytotoxicity induced by CoNPs. Ferroptosis plays an important role in the process that CoNPs induced the cytotoxicity. The effectiveness of ferroptosis inhibition on MG-63 cells may initiate the development of novel strategies for reducing the adverse effects associated with metal implants in future.Trial registration: no human participant.
Cloning, Characterization, and Overexpression in Arabidopsis to Determine the Function of SPL Genes from Woodland Strawberry (Fragaria Vesca)
Authors: Bai Yibo , Liang Morong , Ma Chuangju , Cheng Zongming , Xiong Jinsong 
Published: June 2021

Abstract
SQUAMOSA promoter binding protein-like (SPL) proteins is a class of plant specific transcription factors that play important roles during plant development. However, the majority of SPL genes in strawberry are functionally uncharacterized. In this study, three SPL genes, i.e. FvSPL1, FvSPL2, and FvSPL11 (FvSPL1/2/11), from woodland strawberry were cloned and characterized. Phylogenetic analysis with SPL genes from Arabidopsis, tomato and chrysanthemum indicated that FvSPL1/2/11 were clustered into the same group with those of miR156 target site located at the 3’-untranslated region (UTR). Further biochemical analysis indicated that FvSPL1 was exclusively localized in the nucleus. Electrophoretic mobility shift assay demonstrated FvSPL1 could specifically recognized the GTAC motif. Transcriptional activity analysis showed FvSPL1 was a transcriptional activator that could activate the expression of FvAP1 gene. Finally, all of the transgenic Arabidopsis that overexpression the three FvSPL genes were exhibited significantly early flowering phenotype. Taken together, our study indicated that FvSPL1/2/11 similar to their orthologs in Arabidopsis mainly functions in regulating plant flowering. These results enriched our understanding to the functions of SPL genes in strawberry and might be utilized for strawberry flowering time manipulation in the future.
Job Requirements and Physical Demands (JRPD) Questionnaire: Cross-Cultural Adaptation and Psychometric Evaluation in Iranian Army Personnel with Chronic Low Back Pain
Authors: Ramezani Mehdi , Pourghayoomi Ehsan , Taghizadeh Ghorban 
Published: June 2021

Abstract
Background: Biomechanical risk factors have been identified as the main predisposing factor of Chronic Low Back Pain (CLBP), especially in Army personnel. The Job Requirements and Physical Demands (JRPD) questionnaire has been developed to assess the biomechanical exposures related to CLBP. Examining the biomechanical risk factors could prevent CLBP. This research was designed to cross-cultural adaptation and the psychometric properties of the Persian version of the Job Requirements and Physical Demands (JRPD) questionnaire among Iranian Army personnel with Chronic Low Back Pain (CLBP).Methods: In this non-experimental and methodological designed study, the content validation of the JRPD was performed after translating to Persian. The Persian JRPD was administered to 198 Army personnel with CLBP, with an interval of seven days, to assess test-retest reliability. Scores of the Visual Analog Scale (VAS), Borg's Category-Ratio (CR10) scale, General Health Questionnaire-28 (GHQ-28), and two Physical Functioning (PF1 and PF2) items of the 12-item Short Form survey (SF-12) were recorded to estimate the correlation with the Persian JRPD.Results: After content validation, the number of items in the Persian JRPD remained unchanged. Persian JRPD was correlated with VAS (r = .27; p < .001), Borg's scale (r = .19; p < .009), GHQ-28 (r = .31; p < .001), PF1 (r = -.35; p < .001), and PF2 (r = -.27; p < .001). Also, test-retest reliability and internal consistency values were found to be .80 and .91, respectively.Conclusion: The Persian version of the JRPD is a valid questionnaire with good reliability when applied to Iranian Army personnel with CLBP.
Automated Recognition of Objects and Types of Forceps in Surgical Images Using Deep Learning
Authors: Bamba Yoshiko , Ogawa Shimpei , Itabashi Michio , Kameoka Shingo , Okamoto Takahiro , Yamamoto Masakazu 
Published: June 2021

Abstract
Background: Analysis of operative data with convolutional neural networks (CNNs) is expected to improve the knowledge and professional skills of surgeons. Identification of objects in videos recorded during surgery can be used for surgical skill assessment and surgical navigation. The objectives of this study were to recognize objects and types of forceps in surgical videos acquired during colorectal surgeries and evaluate detection accuracy.Methods: Images (n=1818) were extracted from 11 surgical videos for model training, and another 500 images were extracted from 6 additional videos for validation. The following 5 types of forceps were selected for annotation: ultrasonic scalpel, grasping, clip, angled (Maryland and right-angled), and spatula. IBM Visual Insights software was used, which incorporates the most popular open-source deep-learning CNN frameworks.Results: In total, 1039/1062 (97.8%) forceps were correctly identified among 500 test images. Calculated recall and precision values were as follows: grasping forceps, 98.1% and 98.0%; ultrasonic scalpel, 99.4% and 93.9%; clip forceps, 96.2% and 92.7%; angled forceps, 94.9% and 100%; and spatula forceps, 98.1% and 94.5%, respectively.Conclusions: Forceps recognition can be achieved with high accuracy using deep-learning models, providing the opportunity to evaluate how forceps are used in various operations.
The Role of Long Noncoding RNAs in Patients With Luminal A Invasive Breast Ductal Carcinoma
Authors: Eshghifar Nahal , Rouhollah Fatemeh , Barikrow Nooshin , Pouresmaeili Farkhondeh , Taheri Mohammad 
Published: June 2021

Abstract
Breast cancer is the most common form of cancer in women around the world. The molecular mechanisms of this heterogeneous disease have been extensively investigated; but still; need many sensitive and specific markers for prognostic and early diagnostic approaches. Non-protein coding RNAs known as lncRNAs are reported in tumorogenesis involvement. hence could be used as therapeutic targets.In the present study, we examined the expression levels of CCAT1, PDCD4, PDCD4-AS1, and MEG3 LncRNAs in tumor and adjacent breast tissues in 88 Iranian patients by quantitative real-time PCR. CCAT1 was notably overexpressed and PDCD4-AS1 was decreased in tumor samples, PDCD4 and PDCD4-AS1 showed a positive association with each other, higher levels of PDCD4-AS1 were associated with better survival, tumor samples showed lower levels of PDCD4 compared to normal tissue.Our findings show that lncRNAs play critical roles in controlling post-transcriptional gene expression of key tumor suppressor or oncogenic genes, leading to TNBC progression.As a result, this research looked into the prognostic role of lncRNAs in breast cancer patients.