bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic evaluation of mobile screening station waterless system operation of nickel laterite ore
Authors: Yustian A , Widodo E , Singgih M L 
Published: March 2021

Abstract
The study investigates the economic level of operating the Mobile Screening Station Waterless System (MSSWS) for the first-time application in the nickel laterite mining industry. Three investment alternatives are compared in this study to determine the most economical option, i.e.: maintaining existing Fixed Screening Station/FSS (alternative one), purchasing MSSWS (alternative two), and purchasing new FSS (alternative three). Evaluation is made by performing cost savings analysis, increment cash flow projections, NPV, and IRR calculation. Furthermore, sensitivity analysis of the most economic option will be done as well. The results show that MSSWS gives the highest NPV and IRR. The decreasing of ore hauling distance and water content that are contributed by MSSWS yields significant cost savings in terms of reducing hauled trucks’ investment and its operating cost. In accordance with this analysis, the economics of MSSWS is very sensitive to the changed of ore hauling distance. Therefore, this study has been successfully confirmed that purchasing of MSSWS is the most economical option. In addition to this result, a sensitivity analysis will be undertaken based on the situation that the moving of MSSWS over a certain period once the minimum change in the average ore hauling distance occurs.
Conceptual modeling of resilience measurement during natural disasters for SMEs
Authors: Utami I D , Santosa I , Rifa’i E 
Published: March 2021

Abstract
This study focuses on how to generate resilience information services to natural disasters for SMEs. The information in this study was using software or application developed based on a conceptual model formed as a framework for SMEs’ managers in dealing with natural disasters. The conceptual model was shaped based on actual data from SMEs’ owners and leaders, as well as stakeholders in four regencies in the Madura Island, Indonesia, namely Bangkalan, Sampang, Pamekasan and Sumenep, by identifying the variables or dimensions of SMEs’ resilience to natural disasters. The conceptual model was produced using sequence and use case diagrams to identify the relationship between risk and resilience dimensions to measure the level of resilience of SMEs. The level SMEs’ resilience to natural disasters was the basis of information received by SMEs’ owners and leaders. This study is expected to help SMEs to determine the level of SMEs’ resilience to the risk of natural disasters to minimize the existing risks.
Supplementary quality control features for the production department in Odoo ERP
Authors: Ahmadiyah A S , Ratna Y Y , Yotifa N N , Dinillah I 
Published: March 2021

Abstract
Odoo is one of the top Enterprise Resource Planning (ERP) applications. In particular, it is supported by a quality control module with the ability to control, trigger an alert, and check its purpose. This research strives to supplement the existing Odoo quality control module with parameters from past inspection data obtained before quality control migrates to Odoo. To support the study, we used a machine learning method to discover the intrinsic pattern from the dataset of quality control in the production process of baby biscuit products. The experiment shows that the additional quality control feature can provide the product measurement and tolerance threshold fed into Odoo quality control module. The additional feature is helpful for decision making and error minimization in setting quality control parameters and tolerance threshold. Furthermore, a high accuracy rate of 95.71% is obtained from the employed Decision Tree algorithm.
Analysing the barriers of reverse logistics implementation: A case study
Authors: Pramono S N W , Ulkhaq M M , Aulia Z 
Published: March 2021

AbstractAn increase in both consumers’ environmental awareness and government regulation related to the environment encourages industries to be more responsible for their products after consumption. As a result, a relatively new concept in logistics called reverse logistics (RL) is introduced. While the forward (or traditional) logistics refers to the process of distributing products from companies (or producers) to consumers, RL refers to the process of moving products from consumers to producers. This practice has attracted not only scholars but also practitioners in the field of supply chain and sustainability. A company could gain benefits from the implementation of RL since it can lead to higher profit. However, some barriers regard its implementation despite the benefits that make the company reluctant to implement it. Therefore, this study aims to investigate the barriers to implementing RL in a bottled drinking water company. Moreover, this study also analyses the interaction among the barriers to looking for the possible “root barrier”. The interpretative structural modelling and MICMAC analysis were used to accomplish the objective of the study. It is expected that the study could help the management to better formulate policies about the implementation of RL.
Work system analysis on puncher bar repair process in the production division of Akademi Teknik Soroako (Soroako Technical Academy)
Authors: Burhanuddin  , Dewi R S 
Published: March 2021

Abstract
One of the regular services in the Production Division of Akademi Teknik Soroako (Soroako Technical Academy) is repairing puncher bars of PT Vale Indonesia, One of the stages of his work is to straighten each punch bar. For straightening up each puncher bar, the worker needs to hammer each puncher bar with a 5 kg iron hammer manually. This operation requires enormous physical energy and high cognitive effort for controlling body movement, causing fatigue and cumulative musculoskeletal trauma. The research focuses on assessing the risk of musculoskeletal disorders on the straightening employing Ovako Work Posture Analysis System (OWAS) and Rapid Upper limb Assessment (RULA). The result of the study shows that the work postures while straightening the puncher bar has OWAS score = 2 which means it needs corrective action in the near term, and RULA score = 7 which means the work posture improvement should be made right now. Based on the OWAS and RULA score, several improvement programs and techniques are suggested in this study.
A Theoretical Study of Second Lyapunov Method on Stability of Zero Solution for a Delay Differential System
Authors: Hijab Anas A. , Khalil Muayyad M. 
Published: March 2021

Abstract
This study examined the asymptotic stability of delay differential systems using Lyapunov’s second method. It showed that the zero solutions are asymptotically stable when satisfying some necessary and sufficient conditions. The solution origin of the given system is asymptotically stable for small perturbations, which has no effect on equilibrium system if some conditions are held and it is asymptotically stable for large perturbations that moving system of its equilibrium then its comeback to it if other conditions are held. The proof of theorems in this article results by using and applying Gronwell-Bellman inequality which leads us to main result.
Synthesis of Iron-nickel Particles by Co-precipitation Technique and Used as a Contrast Medium in an MRI Machine
Authors: Mubarak T H , Mahmood O A , Shatti W A 
Published: March 2021

AbstractIn this study, Nickel Zinc Ferrite was prepared using the co-precipitation method according to the chemical formula Ni1-xZnxFe2O4, where the values of (x = 0,0.1,0.3,0.5,0.7,0.9) respectively, the structural and magnetic properties were studied through X-ray diffraction spectroscopy. FESEM showed the porosity and distribution of the homogeneous nanoparticles roughly, also its particle size. The vibration sample Magnetometer (VSM)was used to study magnetic properties, and the Fourier transform infrared (FTIR) spectra were measured in the range of 400-4000 cm−1. Magnetic nanoparticles effect on contrast factors in magnetic resonance imaging (MRI) images was studied, it showed Good and robust imaging technique for diagnosis and post-treatment evaluation for a wide range of diseases. MRI contrast can be enhanced by using negative or positive contrast agents, resulting in clearer (T1-weighted) or darker (T2-weighted) images, respectively, with super-magnetic nanoparticles yielding T2 contrast agents widely used in molecular imaging applications and cellular. As most of the work in this field focuses on the acquisition of biological species using nanoparticles, which in turn will improve the magnetic properties that lead to higher imaging.
Comprehensive health assessment and blood analyte reference intervals of gopher tortoises (Gopherus polyphemus) in southeastern FL, USA
Authors: Page-Karjian Annie , Rafferty Kathleen , Xavier Clerson , Stacy Nicole I , Moore Jon A , Hirsch Sarah E , Clark Samantha , Manire Charles A , Perrault Justin R 
Published: March 2021

AbstractThe gopher tortoise (Gopherus polyphemus), a keystone species, is declining throughout its geographic range. Lack of knowledge with respect to the potential infectious diseases present within wild populations creates a dilemma for wildlife biologists, conservationists and public policy makers. The objective of this study was to conduct a health assessment of two previously unstudied gopher tortoise aggregations located at two sites in southeastern FL. Samples were collected from 91 tortoises (48 adults, 35 juveniles, 8 hatchlings) captured at Florida Atlantic University’s Harbor Branch Oceanographic Institute, in Fort Pierce, FL, USA in 2019, and Loggerhead Park in Juno Beach, FL, USA, during 2018–2019. Samples of blood, nasal swabs and oral/cloacal swabs were analyzed for hematology, plasma protein electrophoretic profiles and infectious disease testing including Mycoplasma spp. serology and polymerase chain reaction (PCR) assays for Ranavirus, Herpesvirus and Anaplasma spp. Hematological and plasma protein electrophoresis reference intervals are presented for adult and juvenile tortoises from both sites combined. Clinical signs consistent with upper respiratory tract disease (URTD) were observed in 18/91 (20%) tortoises, and antibodies to Mycoplasma agassizii were detected in 33/77 (42.9%) tortoises. Adult tortoises were significantly more likely than juveniles to have URTD clinical signs, and statistically significant, positive relationships were observed between the presence of antibodies to Mycoplasma spp. and carapace length, packed cell volume and plasma globulin concentrations. Anaplasma spp. inclusions were observed in 8/82 (10%) tortoises, but PCR detected Anaplasma sp. in 21/83 (25%) tortoises. Herpesvirus and Ranavirus were not detected in any blood or swab samples. This work contributes important baseline information on the health of gopher tortoises toward the southern end of the species’ range.
Management of post-operative subcutaneous emphysema with the application of wound VAC therapy
Authors: Minarich Michael J , Henry Leonard R , Hardy Ashley , von Holzen Urs 
Published: March 2021

Abstract
Extensive subcutaneous emphysema (SE) complicates between 1 and 6% of elective thoracic procedures. The management of SE is varied, and may include increasing the suction of chest tubes, placement of additional chest tubes, placement of subcutaneous drains and creation of releasing incisions. We present five patients with post-operative SE treated successfully with a subcutaneous infraclavicular incision and wound VAC therapy. A 5-cm incision was made 2 cm below the clavicle down and through the pectoralis major fascia. A VAC dressing was fitted to the wound and suction was applied to −125 mm Hg. Data were retrospectively collected and analyzed. VAC dressing was placed a median of 6 days after initial operation. All patients had improvement in symptoms and resolution of SE by VAC dressing therapy. Subcutaneous infraclavicular incision and VAC dressing placement is a viable treatment for patients with post-operative SE who fail conservative therapy.
Model-based analysis of implanted hypoglossal nerve stimulation for the treatment of obstructive sleep apnea
Authors: Johnson Matthew D , Dweiri Yazan M , Cornelius Jason , Strohl Kingman P , Steffen Armin , Suurna Maria , Soose Ryan J , Coleman Michael , Rondoni John , Durand Dominique M , Ni Quan 
Published: March 2021

Abstract

Study Objectives
Individuals with obstructive sleep apnea (OSA), characterized by frequent sleep disruptions from tongue muscle relaxation and airway blockage, are known to benefit from on-demand electrical stimulation of the hypoglossal nerve. Hypoglossal nerve stimulation (HNS) therapy, which activates the protrusor muscles of the tongue during inspiration, has been established in multiple clinical studies as safe and effective, but the mechanistic understanding for why some stimulation parameters work better than others has not been thoroughly investigated.

Methods
In this study, we developed a detailed biophysical model that can predict the spatial recruitment of hypoglossal nerve fascicles and axons within these fascicles during stimulation through nerve cuff electrodes. Using this model, three HNS programming scenarios were investigated including grouped cathode (---), single cathode (o-o), and guarded cathode bipolar (+-+) electrode configurations.

Results
Regardless of electrode configuration, nearly all hypoglossal nerve axons circumscribed by the nerve cuff were recruited for stimulation amplitudes &lt;3 V. Within this range, monopolar configurations required lower stimulation amplitudes than the guarded bipolar configuration to elicit action potentials within hypoglossal nerve axons. Further, the spatial distribution of the activated axons was more uniform for monopolar versus guarded bipolar configurations.

Conclusions
The computational models predicted that monopolar HNS provided the lowest threshold and the least sensitivity to rotational angle of the nerve cuff around the hypoglossal nerve; however, this setting also increased the likelihood for current leakage outside the nerve cuff, which could potentially activate axons in unintended branches of the hypoglossal nerve.

Clinical Trial Registration
NCT01161420.
Estimating design hydrologic extremes in a warming climate: alternatives, uncertainties and the way forward
Authors: Sharma Ashish , Hettiarachchi Suresh , Wasko Conrad 
Published: March 2021

It is now well established that our warming planet is experiencing changes in extreme storms and floods, resulting in a need to better specify hydrologic design guidelines that can be projected into the future. This paper attempts to summarize the nature of changes occurring and the impact they are having on the design flood magnitude, with a focus on the urban catchments that we will increasingly reside in as time goes on. Two lines of reasoning are used to assess and model changes in design hydrology. The first of these involves using observed storms and soil moisture conditions and projecting how these may change into the future. The second involves using climate model simulations of the future and using them as inputs into hydrologic models to assess the changed design estimates. We discuss here the limitations in both and suggest that the two are, in fact, linked, as climate model projections for the future are needed in the first approach to form meaningful projections for the future. Based on the author's experience with both lines of reasoning, this invited commentary presents a theoretical narrative linking these two and identifying factors and assumptions that need to be validated before implementation in practice.
This article is part of a discussion meeting issue ‘Intensification of short-duration rainfall extremes and implications for flash flood risks’.
Using high-resolution climate change information in water management: a decision-makers' perspective
Authors: Orr H. G. , Ekström M. , Charlton M. B. , Peat K. L. , Fowler H. J. 
Published: March 2021

The UK Climate Change Act requires the Environment Agency to report the risks it faces from climate change and actions taken to address these. Derived information from projections is critical to understanding likely impacts in water management. In 2019, the UK published an ensemble of high-resolution model simulations. The UKCP Local (2.2 km) projections can resolve smaller scale physical processes that determine rainfall and other variables at subdaily time-scales with the potential to provide new insights into extreme events, storm runoff and drainage management. However, simulations also need to inform adaptation. The challenge ahead is to identify and provide derived products without the need for further analysis by decision-makers. These include a wider evaluation of uncertainty, narratives about rainfall change across the projections and bias-corrected datasets. Future flood maps, peak rainfall estimates, uplift factors and future design storm profiles also need detailed guidance to support their use. Central government support is justified in the provision of up-to-date impacts information to inform flood risk management, given the large risks and exposure of all sectors. The further development of projections would benefit from greater focus and earlier scoping with industry representatives, operational tool developers and end users.This article is part of a discussion meeting issue ‘Intensification of short-duration rainfall extremes and implications for flash flood risks’.
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 20 state, local, and territorial health departments, March 29, 2020 -January 8, 2021
Authors: Galang Romeo R. , Newton Suzanne M. , Woodworth Kate R. , Griffin Isabel , Oduyebo Titilope , Sancken Christina L. , Olsen Emily O’Malley , Aveni Kathy , Wingate Heather , Shephard Hanna , Fussman Chris , Alaali Zahra S. , Siebman Samantha , Halai Umme-Aiman , Lopez Camille Delgado , Barton Jerusha , Lush Mamie , Patrick Paul H. , Schlosser Levi , Sokale Ayomide , Chaudhary Ifrah , Reynolds Bethany , Sowunmi Similoluwa , Gaarenstroom Nicole , Read Jennifer S. , Chicchelly Sarah , de Wilde Leah , Azziz-Baumgartner Eduardo , Hall Aron J. , Tong Van T. , Ellington Sascha , Gilboa Suzanne M. ,   CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team
Published: March 2021

AbstractBackgroundPregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with COVID-19 are limited. This study aimed to determine risk factors associated with COVID-19 illness severity among pregnant women with SARS-CoV-2 infection.MethodsPregnant women with SARS-CoV-2 infection confirmed by molecular testing were reported during March 29, 2020–January 8, 2021 through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). Criteria for illness severity (asymptomatic, mild, moderate-to-severe, or critical) were adapted from National Institutes of Health and World Health Organization criteria. Crude and adjusted risk ratios for moderate-to-severe or critical COVID-19 illness were calculated for selected demographic and clinical characteristics.ResultsAmong 5,963 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 30–39 years, Black/Non-Hispanic race/ethnicity, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, cardiovascular disease, and pregestational diabetes mellitus. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions.ConclusionsPregnant women with moderate-to-severe or critical COVID-19 illness were more likely to be older and have underlying medical conditions compared to pregnant women with asymptomatic infection or mild COVID-19 illness. This information might help pregnant women understand their risk for moderate-to-severe or critical COVID-19 illness and inform targeted public health messaging.SummaryAmong pregnant women with COVID-19, older age and underlying medical conditions were risk factors for increased illness severity. These findings can be used to inform pregnant women about their risk for severe COVID-19 illness and public health messaging.
MAPK Pathway Inhibition as A Rational Therapeutic Strategy for MiR-138-5p/PAQR3 Dysregulation-mediated Epirubicin Resistance in Triple-negative Breast Cancer
Authors: Huang Jianbo , Zeng Shiyan , Xiao Yun , Wang Xiaoyi , Li Hongyuan , Xiang Tingxiu , Kong Lingquan , Ren Guosheng 
Published: March 2021

AbstractAnthracyclines, such as epirubicin, activate the mitogen-activated protein kinase (MAPK) pathway in breast cancer (BC). Better predictors of tumor response are needed to guide de-intensification of anthracyclines when used in BC treatment. Here, we aimed to see if MAPK activation was responsible and targetable for epirubicin resistance, and to explore mechanisms and predictive markers for resistance. MAPK pathway inhibitors were used to ameliorate epirubicin resistance. Negative regulators of MAPK were screened to identify the essential gene cascades required for activation of the pathway. In vitro and in vivo approaches were applied to investigate epirubicin resistance. The regulatory miRNA was identified through bioinformatics-based screening and luciferase reporter assay. 114 estrogen receptor negative patients who received epirubicin monotherapy were included to evaluate predictive markers for tumor response. The MAPK pathway was activated in cells resistant to epirubicin; MAPK inhibition ameliorated epirubicin resistance. In triple-negative breast cancer (TNBC), progestin and adipoQ receptor 3 (PAQR3) were the most significantly decreased negative MAPK regulators. PAQR3 increased epirubicin sensitivity and suppressed MAPK activation in resistant cells. MiR-138-5p was increased in epirubicin resistant cells, and was shown to downregulate PAQR3, causing resistance in epirubicin resistant cells. PAQR3 was an independent factor in predicting response to epirubicin (OR=4.86, 95%CI=1.13-20.87, P=0.034), and possessed a high negative predictive value (NPV) (0.93; 95%CI=0.83-0.97). In addition, PAQR3 exhibited a better predictive value in patients older than 50 years (12.92 (95% CI, 1.43-116.78, P = 0.023). The combinative use of PAQR3 and topoisomerase II-α (TOP2A) led to an increased specificity (0.70; 95%CI=0.61-0.79), when compared with either PAQR3 or TOP2A alone. MAPK inhibition ameliorated epirubicin resistance. MiR-138-5p-induced PAQR3 reduction causes epirubicin resistance in TNBC via activation of MAPK cascades. PAQR3 is an independent and favorable predictor response to epirubicin in BC.