bluuebunny/crossref_metadata_2025_split huggingface dataset:
In defence of explanatory realism
Authors: Roski Stefan 
Published: September 2021

AbstractExplanatory realism is the view that explanations work by providing information about relations of productive determination such as causation or grounding. The view has gained considerable popularity in the last decades, especially in the context of metaphysical debates about non-causal explanation. What makes the view particularly attractive is that it fits nicely with the idea that not all explanations are causal whilst avoiding an implausible pluralism about explanation. Another attractive feature of the view is that it allows explanation to be a partially epistemic, context-dependent phenomenon. In spite of its attractiveness, explanatory realism has recently been subject to criticism. In particular, Taylor (Philos Stud 175(1):197–219, 2018). has presented four types of explanation that the view allegedly cannot account for. This paper defends explanatory realism against Taylor’s challenges. We will show that Taylor’s counterexamples are either explanations that turn out to provide information about entities standing in productive determination relations or that they are not genuine explanations in the first place.
Contributions to Operational Psychology: Psychological Training Model in the Context of Stress Management for Specialized German Military Police Personnel and Specialized Police Personnel
Authors: Steingräber Anne-Marie , Tübben Nick , Brinkmann Niels , Finkeldey Felix , Migutin Slava , Bürger Anna , Laubstein Alice , Abel Bernd , von Lüdinghausen Nicola , Herzberg Philipp Yorck , Lorei Clemens , Hanssen Niels , Gorzka Robert-Jacek 
Published: September 2021

AbstractThe service of specialized and special forces of the Federal Armed Forces and police is characterized by complex situations. Such personnel often face numerous difficulties and extreme danger and experience periods of high stress when fulfilling their tasks. In the context of social and technological changes, it is necessary to explore the individual components of stress management in further detail, i.e., stress prevention, stress control, and stress coping mechanisms, and furthermore to consider these elements in the fields of training and service. For this purpose, a stress management model was created based on participant observations, expert ratings, and problem-centered interviews with specialized members of military police and special police forces. The results of the validation can be interpreted as suggesting that effective stress management requires a diverse range of techniques and methods, including the use of digital means such as e-learning, digital reality, and eye tracking, in order to be able to address new demands appropriately.
Safety and efficacy of peptide receptor radionuclide therapy with 177Lu-DOTA0-Tyr3-octreotate in combination with amino acid solution infusion in Japanese patients with somatostatin receptor-positive, progressive neuroendocrine tumors
Authors: Kobayashi Noritoshi , Takano Shoko , Ito Kenichi , Sugiura Madoka , Ogawa Matsuyoshi , Takeda Yuma , Okubo Naoki , Suzuki Akihiro , Tokuhisa Motohiko , Kaneta Tomohiro , Utsunomiya Daisuke , Hata Masaharu , Inoue Tomio , Hosono Makoto , Kinuya Seigo , Ichikawa Yasushi 
Published: September 2021

Abstract
Purpose
Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTA0-Tyr3-octreotate (177Lu-DOTATATE) is one of the most reliable treatments for unresectable, progressive neuroendocrine tumors (NETs) with somatostatin receptor expression. We have, for the first time, reported the results of the tolerability, safety, pharmacokinetics, dosimetry, and efficacy of this treatment for Japanese patients with NET.

Methods
Patients with unresectable, somatostatin receptor scintigraphy (SRS)-positive NETs were enrolled in this phase I clinical trial. They were treated with 29.6 GBq of 177Lu-DOTATATE (four doses of 7.4 GBq) combined with amino acid solution infusion plus octreotide long-acting release (LAR) 30 mg. The primary objective of this study was to evaluate the tolerability, safety, pharmacokinetics, and dosimetry of a single administration of this treatment in patients with SRS-positive NETs.

Results
Six Japanese patients (three men and three women; mean age 61.5 years; range 50–70 years) with SRS-positive unresectable NETs were recruited. 177Lu-DOTATATE was eliminated from the blood in a two-phase manner. Cumulative urinary excretion of radioactivity was 60.1% (range 49.0%–69.8%) within the initial 6 h. The cumulative renal absorbed dose for 29.6 GBq of 177Lu-DOTATATE was 16.8 Gy (range 12.0–21.2 Gy), and the biological effective dose was 17.0 Gy (range 12.2–21.5 Gy). Administration of 177Lu-DOTATATE was well tolerated, with no dose-limiting toxicities. Grade 3 lymphopenia occurred in two (33.3%) cases, but there were no other severe toxicities. Four patients achieved partial response (objective response rate, 66.7%), one patient had stable disease, and one patient had progressive disease.

Conclusion
PRRT with 177Lu-DOTATATE was well-tolerated and showed good outcomes in Japanese patients with unresectable NETs. Peptide receptor radionuclide therapy, 177Lu-DOTA0-Tyr3-octreotate .
Kinderschmerztherapie – ein Stiefkind?
Authors: Sator Sabine 
Published: September 2021

ZusammenfassungDiagnosefindung und eine spezifische Schmerztherapie bei Kindern mit chronischen Schmerzen ist oft langwierig und leider insuffizient. Viele Medikamente, die am internationalen Markt zur Verfügung stehen, sind off label. Nur wenige Studien belegen die Wirksamkeit und Nebenwirkung in der Kinderschmerztherapie. Deshalb sind Kinder nach wie vor stiefmütterlich behandelt. Jedoch können auch Kinder jedes Alters eine adäquate multimodale Schmerztherapie erhalten.
Comparison of emissions from smokeless coal combustion in a household heating boiler used in Central Europe
Authors: Knigawka P. , Pianko-Oprych P. , Krpec K. , Kuboňová L. 
Published: September 2021

AbstractThe objective of this work was to evaluate the relationship between the fuel quality and the gaseous and particulate pollutant emissions generated from a hot-water boiler during the combustion of different types of innovative processed fuels: smokeless coal, smokeless briquettes 1–3, smokeless pellets and unprocessed hard coal. The aim of our research was to prove the presumption that smokeless processed coals produce less gaseous and particulate emissions. By using modern fuels in already used and manufactured older boilers, there is a possibility to significantly reduce emissions of organic gaseous compounds (OGC) and polycyclic aromatic hydrocarbons (PAHs). The emission situation in the heating season can be significantly improved even without costly production, and thus consumption of natural resources and energy, and installation of modern boilers. Physical and chemical characterization of solid-fuel samples, including determination of moisture content, ash, volatile organic content, calorific value and elemental composition analysis, were performed. Fuels were burned in one type of hot-water boiler class 1 according to EN 303-5 to determine the impact of applied fuel types on pollutant emissions. The pollutant emissions were characterized by the contents of gaseous components: nitrogen oxides NOx, sulfur dioxide SO2, carbon monoxide CO, carbon dioxide CO2, organic gaseous compounds OGC and particle components: total suspended particles TSP, particulate matter less than 2.5 µm and 10 µm (PM2.5 and PM10, respectively) and polycyclic aromatic hydrocarbons PAHs in both phases. The emission factors from six types of fuel were compared with applicable European standards. The lowest NOx content was observed for smokeless briquette 1, while the lowest SO2 content was observed for smokeless pellets. The emission of CO was at a similarly low level of 200 g/kg for smokeless briquette 1, smokeless briquette 2 and hard coal. Gaseous and pollutant emissions described by PM2.5 and TSP were observed to be the lowest for smokeless coal, smokeless briquette 1 and smokeless briquette 2.
Reflections on Research: Race and the Virginia Blue Ridge
Authors: Horning Audrey 
Published: September 2021

AbstractIn the 1930s, Shenandoah National Park was established in the Virginia Blue Ridge through the displacement of nearly 500 white families. In recent decades, my scholarship and that of others focused upon the manner in which hackneyed stereotypes about backward mountaineers were mobilized to garner public support for the condemnation of family farms and, in some cases, the institutionalization, sterilization, and incarceration of some of the most impoverished. But, in focusing solely upon the 20th century and the impacts on the white displaced, this research has perpetrated structural violence by obscuring the role of race and racism in the wider Blue Ridge. Archaeological and documentary evidence from the 1990s National Park Service–funded “Survey of Rural Mountain Settlement” is reexamined and reconsidered to begin the process of redressing the silencing of African American histories in the Blue Ridge and surrounding valley and piedmont regions.
Electric polarization and crystal orientation of lead zirconate titanate under mechanical stress due to embedding in a metal matrix
Authors: Yanaseko Tetsuro , Sato Hiroshi , Narita Fumio , Asanuma Hiroshi 
Published: September 2021

AbstractThe mechanical characteristics of piezoelectric ceramic fibers can be improved by embedding the fibers in a metal matrix. The compressive stress generated during the embedding process, however, limits the polarization of piezoelectric ceramic composites. To study and determine the relationship between the mechanical and piezoelectric properties of piezoelectric ceramics, we analyzed the crystallographic orientation of piezoelectric ceramics embedded in an aluminum matrix via electron backscatter diffraction. The orientation of the crystals before and after the polarization of the piezoelectric fibers, in which residual stresses were generated during embedding, was evaluated. Furthermore, the residual stresses were reduced by heat treatment, and the resultant angle of orientation was evaluated before and after polarization. Results showed that, as the residual stresses were relieved, the orientation of the piezoelectric ceramic crystals changed to reveal increased polarization. Our analysis shows that the crystal orientation of piezoelectric ceramics is impacted by the residual compressive stress that arises from embedding the piezoelectric fiber in the aluminum matrix; it also illustrates the hindering effect of residual stress on the polarization of piezoelectric ceramics.
First Peoples in a New World
Authors: Meltzer David J. 
Published: September 2021

Over 15,000 years ago, a band of hunter-gatherers became the first people to set foot in the Americas. They soon found themselves in a world rich in plants and animals, but also a world still shivering itself out of the coldest depths of the Ice Age. The movement of those first Americans was one of the greatest journeys undertaken by ancient peoples. In this book, David Meltzer explores the world of Ice Age Americans, highlighting genetic, archaeological, and geological evidence that has revolutionized our understanding of their origins, antiquity, and adaptation to climate and environmental change. This fully updated edition integrates the most recent scientific discoveries, including the ancient genome revolution and human evolutionary and population history. Written for a broad audience, the book can serve as the primary text in courses on North American Archaeology, Ice Age Environments, and Human evolution and prehistory.
Between the Pagan Past and Christian Present in Byzantine Visual Culture
Authors: Chatterjee Paroma 
Published: September 2021

Up to its pillage by the Crusaders in 1204, Constantinople teemed with magnificent statues of emperors, pagan gods, and mythical beasts. Yet the significance of this wealth of public sculpture has hardly been acknowledged beyond late antiquity. In this book, Paroma Chatterjee offers a new perspective on the topic, arguing that pagan statues were an integral part of Byzantine visual culture. Examining the evidence in patriographies, chronicles, novels, and epigrams, she demonstrates that the statues were admired for three specific qualities - longevity, mimesis, and prophecy; attributes that rendered them outside of imperial control and endowed them with an enduring charisma sometimes rivaling that of holy icons. Chatterjee's interpretations refine our conceptions of imperial imagery, the Hippodrome, the Macedonian Renaissance, a corpus of secular objects, and Orthodox icons. Her book offers novel insights into Iconoclasm and proposes a more truncated trajectory of the holy icon in medieval Orthodoxy than has been previously acknowledged.
A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach
Authors: Wang Xing-Yi , Merlo Adlan , Dupont Claire , Salsac Anne-Virginie , Barthès-Biesel Dominique 
Published: September 2021

We present a microfluidic method to measure the elastic properties of a population of microcapsules (liquid drops enclosed by a thin hyperelastic membrane). The method is based on the observation of flowing capsules in a cylindrical capillary tube and an automatic inverse analysis of the deformed profiles. The latter requires results from a full numerical model of the fluid–structure interaction accounting for nonlinear membrane elastic properties. For ease of use, we provide them under the form of databases, when the initially spherical capsule has a membrane governed by a neo-Hookean or a general Hooke's law with different surface Poisson ratios. Ultimately, the microfluidic method yields information on the type of elastic constitutive law that governs the capsule wall material together with the value of the elastic parameters. The method is applied to a population of ovalbumin microcapsules and is validated by means of independent experiments of the same capsules subjected to a different flow in a microrheological device. This is of great interest for quality control purposes, as small samples of capsule suspensions can be diverted to a measuring test section and mechanically tested with a 10 % precision using an automated process.
Variability in antimicrobial use among infants born at <33 weeks gestational age
Authors: Ting Joseph Y. , Roberts Ashley , Abou Mehrem Ayman , Khurshid Faiza , Drolet Christine , Monterrosa Luis , Yoon Eugene W. , Shah Prakesh S. 
Published: September 2021

AbstractExcessive antimicrobial use is associated with adverse neonatal outcomes. In our cohort of 27,163 infants born at <33 weeks gestational age, the first week after birth accounted for the highest rates of antimicrobial use, and variability across sites persisted after adjustment for patient characteristics correlated with illness severity.
Identifying phenotypic and physiological subgroups of preschoolers with autism spectrum disorder
Authors: Bazelmans Tessel , Jones Emily J. H. , Ghods Sheila , Corrigan Sarah , Toth Karen , Charman Tony , Webb Sara J. 
Published: September 2021

AbstractBackgroundTo understand the emergence of symptoms in autism spectrum disorder (ASD), we need to identify the mechanisms that underpin the development of core social skills. Mounting evidence indicates that young children with later ASD attend less to other people, which could compromise learning opportunities with cascading effects. Passive looking behaviour does not tell us about engagement with visual information, but measures of physiological arousal can provide information on the depth of engagement. In the current study, we use heart rate (HR) and heart rate variability (HRV) to measure engagement with social dynamic stimuli in ASD.MethodsSixty-seven preschoolers with ASD and 65 typical developing preschoolers between 2 and 4 years of age participated in a study where HR was measured during viewing of social and non-social videos. Using latent profile analyses, more homogeneous subgroups of children were created based on phenotype and physiology.ResultsPreschool-aged children with ASD, regardless of their non-verbal, verbal and social competencies, do not differ in overall HR or HRV compared to TD children. However, the ASD group showed a larger increase in HR (more disengagement) than the TD group to later-presented social stimuli. Phenotypic and physiological profiles showed this was primarily the case for children with below average verbal and non-verbal skills, but not necessarily those with more ASD symptoms.ConclusionChildren with ASD, especially a subgroup showing moderate cognitive delays, show an increase in HR to social stimuli over time; this may reflect difficulties re-engaging with social information when attention is waning.
‘Use your words’: Vocalization and moral order in an oral preschool classroom for deaf or hard-of-hearing children
Authors: Montiegel Kristella 
Published: September 2021

AbstractThis ethnographic study examines deaf or hard-of-hearing children's socialization in an oral classroom, a setting designed to promote spoken language as the primary mode of communication. Drawing from nine months of observations, I describe how the meanings assigned to children's vocalizations create a system of values and judgements that organizes and regulates classroom behavior. Specifically, vocalization itself is oriented to as a moral practice that is necessary for the mutual understanding and accomplishment of classroom activities. Informed by ethnomethodological and language-socialization perspectives, I illustrate how participants co-construct a local moral order wherein students are held accountable for ‘using their words’ to perform social actions. Analyses discuss three interactional contexts where moral issues are routinely constructed as contingent on and resolvable through vocalization—children's help-seeking, children's disputes, and negotiations of classroom participation—thereby shaping children's understanding of language use and reflecting broader institutional expectations and ideology regarding oral communication. (Moral order, preschool children, socialization)*
Ordering and aging properties of systems with dependent components governed by the Archimedean copula
Authors: Sahoo Tanmay , Hazra Nil Kamal 
Published: September 2021

AbstractCopula is one of the widely used techniques to describe the dependency structure between components of a system. Among all existing copulas, the family of Archimedean copulas is the popular one due to its wide range of capturing the dependency structures. In this paper, we consider the systems that are formed by dependent and identically distributed components, where the dependency structures are described by Archimedean copulas. We study some stochastic comparisons results for series, parallel, and general $r$-out-of-$n$ systems. Furthermore, we investigate whether a system of used components performs better than a used system with respect to different stochastic orders. Furthermore, some aging properties of these systems have been studied. Finally, some numerical examples are given to illustrate the proposed results.
An unusual case of concurrent Kounis syndrome and prolonged QT in a young patient
Authors: Erdogan Emrah , Cap Murat , Kus Gorkem , Gokhan Cem , Kilic Yakup 
Published: September 2021

AbstractAllergic reactions related to drug use is a common entity presenting often from minor urticaria to life-threatening anaphylactoid reactions. A common but easily overlooked diagnosis, Kounis syndrome, is an established hypersensitivity coronary disorder induced by drugs, foods, environmental factors, and coronary stents that can present in the same way as non-allergy-induced acute coronary syndrome. Here within, we present a unique case of dual presentation of Kounis syndrome and prolonged QTc in a young patient after a single dose of Domperidone and Lansoprazole.
Retracted: Earth System Model Analysis of How Astronomical Forcing Is Imprinted Onto the Marine Geological Record: The Role of the Inorganic (Carbonate) Carbon Cycle and Feedbacks
Authors: Vervoort Pam , Kirtland Turner Sandra , Rochholz Fiona , Ridgwell Andy 
Published: September 2021

AbstractAstronomical cycles are strongly expressed in marine geological records, providing important insights into Earth system dynamics and an invaluable means of constructing age models. However, how various astronomical periods are filtered by the Earth system and the mechanisms by which carbon reservoirs and climate components respond, particularly in absence of dynamic ice sheets, is unclear. Using an Earth system model that includes feedbacks between climate, ocean circulation, and inorganic (carbonate) carbon cycling relevant to geological timescales, we systematically explore the impact of astronomically modulated insolation forcing and its expression in model variables most comparable to key paleoceanographic proxies (temperature, the δ13C of inorganic carbon, and sedimentary carbonate content). Temperature predominately responds to short and long eccentricity and is little influenced by the modeled carbon cycle feedbacks. In contrast, the cycling of nutrients and carbon in the ocean generates significant precession power in atmospheric CO2, benthic ocean δ13C, and sedimentary wt% CaCO3, while inclusion of marine sedimentary and weathering processes shifts power to the long eccentricity period. Our simulations produce reduced pCO2 and dissolved inorganic carbon (DIC) δ13C at long eccentricity maxima and, contrary to early Cenozoic marine records, CaCO3 preservation in the model is enhanced during eccentricity‐modulated warmth. Additionally, the magnitude of δ13C variability simulated in our model underestimates marine proxy records. These model‐data discrepancies hint at the possibility that the Paleogene silicate weathering feedback was weaker than modeled here and that additional organic carbon cycle feedbacks are necessary to explain the full response of the Earth system to astronomical forcing.
Geochemically Defined Mean Position of the Intertropical Convergence Zone in the Central Pacific
Authors: Seo Inah , Kim Mun Gi , Yoo Chan Min , Hyeong Kiseong 
Published: September 2021

AbstractThe Intertropical Convergence Zone (ITCZ) is a band of vigorous convection and high precipitation formed by the confluence of southeasterly and northeasterly trade winds, and acts as a barrier to cross‐equatorial dust transport. We investigate the provenance of dust in the surface sediments of 16 cores collected along a 131.5°W transect from the equator to 16°N in the central Pacific. The results reveal well‐defined Asian dust signals north of 7°N and mixed Asian–South American source signals south of 6°N. We propose the southernmost latitude with an intact Asian source signal (7°N) as the present‐day mean ITCZ position in terms of dust provenance in the central Pacific. This geochemically defined mean ITCZ position reflects differences in thermal and dust fluxes between hemispheres and can be used as a reference for quantitatively assessing ITCZ displacement in the sedimentary down‐core records back to ca. 14 Ma.