bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview for the Nanoparticles‐Based Quantitative Lateral Flow Assay
Authors: Wang Zhongxing , Zhao Jing , Xu Xinxin , Guo Lingling , Xu Liguang , Sun Maozhong , Hu Shudong , Kuang Hua , Xu Chuanlai , Li Aike 
Published: December 2021

AbstractThe development of the lateral flow assay (LFA) has received much attention in both academia and industry because of their broad applications to food safety, environmental monitoring, clinical diagnosis, and so forth. The user friendliness, low cost, and easy operation are the most attractive advantages of the LFA. In recent years, quantitative detection has become another focus of LFA development. Here, the most recent studies of quantitative LFAs are reviewed. First, the principles and corresponding formats of quantitative LFAs are introduced. In the biomaterial and nanomaterial sections, the detection, capture, and signal amplification biomolecules and the optical, fluorescent, luminescent, and magnetic labels used in LFAs are described. The invention of dedicated strip readers has drawn further interest in exploiting the better performance of LFAs. Therefore, next, the development of dedicated reader devices is described and the usefulness and specifications of these devices for LFAs are discussed. Finally, the applications of LFAs in the detection of metal ions, biotoxins, pathogenic microorganisms, veterinary drugs, and pesticides in the fields of food safety and environmental health and the detection of nucleic acids, biomarkers, and viruses in clinical analyses are summarized.
Pharmacology of enflicoxib, a new coxib drug: Efficacy and dose determination by clinical and pharmacokinetic‐guided approach for the treatment of osteoarthritis in dogs based on an acute arthritis induction model
Authors: Cendrós Josep‐Maria , Salichs Marta , Encina Gregorio , Vela Jose Miguel , Homedes Josep M. 
Published: December 2021

AbstractEnflicoxib is a newly developed NSAID of the coxib class. The optimal therapeutic dose to be confirmed in the field studies was established using a combination of pharmacokinetic (PK) modelling and pharmacodynamic (PD) studies. First, a PK study was performed to determine the plasmatic profile of enflicoxib and its active pyrazol metabolite in dogs. Thereafter, two studies using a urate crystal‐induced acute arthritis model allowed to correlate efficacy with plasmatic concentrations. Finally, a population PK model was developed to establish the Minimum Effective Concentration (MEC) and the Maximum Tolerated Concentration (MTC). Enflicoxib plasma concentrations were highest for the first 48 h. Thereafter, pyrazol metabolite concentrations were higher and persisted up to the end of the study. No reduction on the lameness (CLS) or pain scores (PS) was observed in the first hours after enflicoxib administration so no MEC could be established for the parent compound. Both CLS and PS were greatly reduced when the pyrazol metabolite achieved concentrations of 411 ng/ml or higher, so this concentration was established as the MEC for the pyrazol metabolite. Enflicoxib MTC was established at 6723 ng/ml whereas for the pyrazol metabolite it was 4258 ng/ml. The population PK model showed that a loading enflicoxib dose of 8 mg/kg followed by weekly maintenance doses of 4 mg/kg would achieve stable concentrations of the pyrazol metabolite within the therapeutic window (between the MEC and the MTC), and it was considered the most adequate posology to be confirmed in the field clinical studies for the treatment of canine osteoarthritis.
Semantic Interoperability for Logistics and Beyond
Authors: Franke Marco , Hribernik Karl , Thoben Klaus-Dieter 
Published: December 2021

AbstractA Semantic Mediator was conceived in the CRC 637 (The Collaborative Research Centre 637 “Autonomous Cooperating Logistic Processes” focused on adaptive logistic processes including autonomous capabilities for the decentralised coordination of autonomous logistic objects in a heterarchical structure.) to tackle problems of interoperability of heterogeneous information sources in autonomous cooperating logistics processes. Since the conclusion of the CRC 637, the Semantic Mediator has been developed further and successfully transferred to interoperability problems in different domains, including Industry 4.0, the Internet of Things, and Product Lifecycle Management. This paper will introduce the Semantic Mediator and present examples of its successful application.
The persistent place at Lubrza: a small paradise for hunter-gatherers? Multi-disciplinary studies of Late Palaeolithic environment and human activity in the Łagów lake district (western Poland)
Authors: Sobkowiak-Tabaka Iwona , Milecka Krystyna , Kubiak-Martens Lucy , Pawłowski Dominik , Kurzawska Aldona , Janczak-Kostecka Beata , Kostecki Robert , Hildebrandt-Radke Iwona , Apolinarska Karina , Goslar Tomasz 
Published: December 2021

AbstractThis paper summarises the results of multidisciplinary research, including pollen, plant macroremains, diatoms, Cladocera, molluscs and geochemistry from a 14C dated core and geomorphological records, which reconstruct the palaeoenvironmental conditions faced by Late Palaeolithic hunter-gathers in western Poland. Particular attention was paid to evidence for both human activity and the degree to which Late Palaeolithic groups may have affected the local environment, as recorded by the biogenic sediments in lakes located close to their campsites. Vegetation first appears locally in the Oldest Dryas, and consisted of subarctic tundra vegetation. During the Bølling period the landscape was generally open, with dwarf shrubs and scattered patches of Juniperus and Hippophaë shrubs. Betula (tree birch) expanded locally in the area only in the later Allerød; during the second part of the Allerød period, Pinus and Populus joined birch as a sparse woodland developed. During the Younger Dryas, the landscape changed significantly in comparison to the preceding warm period, as result of cooling and drying of the climate. The presence of microscopic charcoal and charred herbaceous plant particles made it possible to detect human activity. These analyses allowed us to reconstruct fire events near the site during its occupation by Hamburg and Federmesser cultural groups. An increase in the proportion of biogenic elements such as Na, K and Mg in the sediments indicate soil erosion, reflecting the activity of Hamburg groups. A relative increase in the frequency of Cladocera which favour eutrophic and turbid water was recorded in the period linked to Federmesser group activities. The intense use of this area was also indicated during the Younger Dryas.
Enhancing Linear Algebraic Computation of Logic Programs Using Sparse Representation
Authors: Nguyen Tuan Quoc , Inoue Katsumi , Sakama Chiaki 
Published: December 2021

AbstractAlgebraic characterization of logic programs has received increasing attention in recent years. Researchers attempt to exploit connections between linear algebraic computation and symbolic computation to perform logical inference in large-scale knowledge bases. In this paper, we analyze the complexity of the linear algebraic methods for logic programs and propose further improvement by using sparse matrices to embed logic programs in vector spaces. We show its great power of computation in reaching the fixed point of the immediate consequence operator. In particular, performance for computing the least models of definite programs is dramatically improved using the sparse matrix representation. We also apply the method to the computation of stable models of normal programs, in which the guesses are associated with initial matrices, and verify its effect when there are small numbers of negation. These results show good enhancement in terms of performance for computing consequences of programs and depict the potential power of tensorized logic programs.
Determinants of fibrotic atrial cardiomyopathy in atrial fibrillation. A multicenter observational study of the RETAC (reseau européen de traîtement d’arrhythmies cardiaques)-group
Authors: Müller-Edenborn Björn , Moreno-Weidmann Zoraida , Venier Sandrine , Defaye Pascale , Park Chan-il , Guerra José , Alonso-Martín Concepcion , Bazan Victor , Vinolas Xavier , Rodriguez-Font Enrique , Garcia Bieito Campos , Boveda Serge , Combes Stéphane , Albenque Jean-Paul , Guy-Moyat Benoit , Trenk Dietmar , Eichenlaub Martin , Chen Juan , Lehrmann Heiko , Neumann Franz-Josef , Arentz Thomas , Jadidi Amir 
Published: December 2021

Abstract
Aims
Despite advances in interventional treatment strategies, atrial fibrillation (AF) remains associated with significant morbidity and mortality. Fibrotic atrial myopathy (FAM) is a main factor for adverse outcomes of AF-ablation, but complex to diagnose using current methods. We aimed to derive a scoring system based entirely on easily available clinical parameters to predict FAM and ablation-success in everyday care.

Methods
In this multicenter, prospective study, a new risk stratification model termed AF-SCORE was derived in 220 patients undergoing high-density left-atrial(LA) voltage-mapping to quantify FAM. AF-SCORE was validated for FAM in an external mapping-validation cohort (n = 220) and for success following pulmonary vein isolation (PVI)-only (without adjunctive left- or right atrial ablations) in an external outcome-validation cohort (n = 518).

Results
FAM was rare in patients < 60 years (5.4%), but increased with ageing and affected 40.4% (59/146) of patients ≥ 60 years. Sex and AF-phenotype had additional predictive value in older patients and remained associated with FAM in multivariate models (odds ratio [OR] 6.194, p < 0.0001 for ≥ 60 years; OR 2.863, p < 0.0001 for female sex; OR 41.309, p < 0.0001 for AF-persistency). Additional clinical or diagnostic variables did not improve the model. AF-SCORE (+ 1 point for age ≥ 60 years and additional points for female sex [+ 1] and AF-persistency [+ 2]) showed good discrimination to detect FAM (c-statistic 0.792) and predicted arrhythmia-freedom following PVI (74.3%, 54.7% and 45.5% for AF-SCORE ≤ 2, 3 and 4, respectively, and hazard ratio [HR] 1.994 for AF-SCORE = 3 and HR 2.866 for AF-SCORE = 4, p < 0.001).

Conclusions
Age, sex and AF-phenotype are the main determinants for the development of FAM. A low AF-SCORE ≤ 2 is found in paroxysmal AF-patients of any age and younger patients with persistent AF irrespective of sex, and associated with favorable outcomes of PVI-only. Freedom from arrhythmia remains unsatisfactory with AF-SCORE ≥ 3 as found in older patients, particularly females, with persistent AF, and future studies investigating adjunctive atrial ablations to PVI-only should focus on these groups of patients.

Graphical abstract
Combined acquisition of diffusion and T2*-weighted measurements using simultaneous multi-contrast magnetic resonance imaging
Authors: Breutigam Nora-Josefin , Günther Matthias , Hoinkiss Daniel Christopher , Eickel Klaus , Frost Robert , Buck Mareike Alicja , Porter David A. 
Published: December 2021

Abstract
Object
In this work, we present a technique called simultaneous multi-contrast imaging (SMC) to acquire multiple contrasts within a single measurement. Simultaneous multi-slice imaging (SMS) shortens scan time by allowing the repetition time (TR) to be reduced for a given number of slices. SMC imaging preserves TR, while combining different scan types into a single acquisition. This technique offers new opportunities in clinical protocols where examination time is a critical factor and multiple image contrasts must be acquired.

Materials and methods
High-resolution, navigator-corrected, diffusion-weighted imaging was performed simultaneously with T2*-weighted acquisition at 3 T in a phantom and in five healthy subjects using an adapted readout-segmented EPI sequence (rs-EPI).

Results
The results demonstrated that simultaneous acquisition of two contrasts (here diffusion-weighted imaging and T2*-weighting) with SMC imaging is feasible with robust separation of contrasts and minimal effect on image quality.

Discussion
The simultaneous acquisition of multiple contrasts reduces the overall examination time and there is an inherent registration between contrasts. By using the results of this study to control saturation effects in SMC, the method enables rapid acquisition of distortion-matched and well-registered diffusion-weighted and T2*-weighted imaging, which could support rapid diagnosis and treatment of acute stroke.
Morbidity profiles in Europe and Israel: international comparisons from 20 countries using biopsychosocial indicators of health via latent class analysis
Authors: Beller Johannes 
Published: December 2021

Abstract
Aim
I examined health/morbidity profiles across 20 countries, determined their associated demographic characteristics and risk factors and compared the distribution of these health/morbidity profiles across countries.

Subject and methods
I used population-based data drawn from the European Social Survey (N = 20092, 52% female, ages 40+) covering 20 mostly European countries (Austria, Belgium, Czechia, Denmark, Finland, France, Germany, Great Britain, Hungary, Ireland, Israel, Lithuania, Netherlands, Norway, Poland, Portugal, Slovenia, Spain, Sweden and Switzerland) from 2014. Diverse indicators of health/morbidity were used, including self-rated health, self-rated disability, self-reported health problems and mental health symptoms using the CES-D. Latent class analysis was conducted to determine health/morbidity profiles across countries.

Results
I found that four distinct health profiles best describe overall health/morbidity status in the international sample, each associated with specific demographic and behavioural risk factors: ‘healthy’ profile (62% of participants), ‘unhappy but healthy’ profile (14%), ‘high morbidity, mostly physical’ profile (16%) and ‘high morbidity, mostly psychological’ profile (8%). With few exceptions, participants from Northern Europe and Western Europe were more likely to belong to the ‘healthy’ and the ‘unhappy but healthy’ profiles, whereas participants from Eastern Europe were more likely to belong to the ‘high morbidity, mostly physical’ profile. Distribution of the ‘high morbidity, mostly psychological’ profile appeared to be more uniform across regions.

Conclusions
Distinct morbidity/health profiles could be identified across countries, and countries varied regarding the relative distribution of these profiles. Specific prevention and treatment consequences associated with each profile are discussed. Future studies should further investigate the patterns of overall health and morbidity in Europe’s populations.
Detection of the Phoma pathogens Plenodomus biglobosus subclades ‘brassicae’ and ‘canadensis’ on wasabi, and ‘canadensis’ in Europe
Authors: King Kevin M. , West Jonathan S. 
Published: December 2021

Abstract
Phoma stem canker / blackleg is an internationally important disease of Brassicas including B. napus (oilseed rape, OSR), caused by multiple genetic subclades of the fungi Plenodomus lingam (formerly Leptosphaeria maculans) and P. biglobosus (L. biglobosa). In Spring 2021, Phoma-like disease symptoms were observed on leaves and stems of Eutrema japonicum (wasabi) crops at three UK sites (Northern Ireland, Southern England and the West Midlands). Fungal isolation from wasabi leaf spots yielded colonies with two distinct phenotypes on potato dextrose agar (PDA). Isolates from the Northern Ireland and Southern England sites had white colonies with abundant pink cirri that were confirmed (based on ITS rDNA, beta tubulin and actin sequences) as P. biglobosus subclade ‘canadensis’ (Pbc). Those from the West Midlands site, however, had yellow pigmented colonies and were confirmed by sequencing as P. biglobosus subclade ‘brassicae’ (Pbb). Greenhouse pathogenicity testing showed that Pbb and Pbc wasabi isolates were pathogenic not only to this host but also OSR, B. oleracea (cabbage), and B. rapa (pak choi). Re-isolation of the fungi was attempted and confirmed from lesions that developed on inoculated OSR and wasabi, thus completing Koch’s postulates. These findings represent new discoveries for both Pbb and Pbc on wasabi, plus for Pbc in Europe. The crop health implications of these results are briefly considered.
Immunity and inflammation: the neglected key players in congenital heart disease?
Authors: Wienecke Laura M. , Cohen Sarah , Bauersachs Johann , Mebazaa Alexandre , Chousterman Benjamin G. 
Published: December 2021

AbstractAlthough more than 90% of children born with congenital heart disease (CHD) survive into adulthood, patients face significantly higher and premature morbidity and mortality. Heart failure as well as non-cardiac comorbidities represent a striking and life-limiting problem with need for new treatment options. Systemic chronic inflammation and immune activation have been identified as crucial drivers of disease causes and progression in various cardiovascular disorders and are promising therapeutic targets. Accumulating evidence indicates an inflammatory state and immune alterations in children and adults with CHD. In this review, we highlight the implications of chronic inflammation, immunity, and immune senescence in CHD. In this context, we summarize the impact of infant open-heart surgery with subsequent thymectomy on the immune system later in life and discuss the potential role of comorbidities and underlying genetic alterations. How an altered immunity and chronic inflammation in CHD influence patient outcomes facing SARS-CoV-2 infection is unclear, but requires special attention, as CHD could represent a population particularly at risk during the COVID-19 pandemic. Concluding remarks address possible clinical implications of immune changes in CHD and consider future immunomodulatory therapies.
Investigation of the pathophysiology of the retina and choroid in Parkinson's disease by optical coherence tomography
Authors: Kamata Yasuaki , Hara Naoto , Satou Tsukasa , Niida Takahiro , Mukuno Kazuo 
Published: December 2021

Abstract
Purpose
The pathology of Parkinson's disease (PD) is suspected to affect the retina and choroid. We investigated changes in the retina and choroid of patients with PD using optical coherence tomography.

Methods
We examined 14 patients with PD and 22 patients without PD. Patients without PD had no ophthalmic disease other than cataracts. In addition, it was also confirmed that there was no neurodegenerative disease. The retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and choroidal thickness were compared between both groups. Additionally, the choroidal image was divided into the choroid area, luminal area, and interstitial area using the binarization method, and the area of each region and the percentage of luminal area in the choroid area were analyzed.

Results
Patients with PD had a significantly thinner ganglion cell layer + inner plexiform layer compared to those without PD. The choroid area, luminal area, and interstitial area were significantly decreased in patients with PD compared to those without PD. Seven patients with PD who were successfully followed up showed decreased retinal nerve fiber layer and interstitial area after 3 years.

Conclusion
Autonomic nervous disorders and neurodegeneration in PD can cause thinning of the retina and choroid, as well as a reduction in the choroid area.
3D Integrated Structural, Facies and Petrophysical Static Modeling Approach for Complex Sandstone Reservoirs: A Case Study from the Coniacian–Santonian Matulla Formation, July Oilfield, Gulf of Suez, Egypt
Authors: Ali Ahmed M. , Radwan Ahmed E. , Abd El-Gawad Esam A. , Abdel-Latief Abdel-Sattar A. 
Published: December 2021

AbstractThe Coniacian–Santonian Matulla Formation is one of the important reservoirs in the July oilfield, Gulf of Suez Basin. However, this formation is characterized by uncertainty due to the complexity of reservoir architecture, various lithologies, lateral facies variations and heterogeneous reservoir quality. These reservoir challenges, in turn, affect the effectiveness of further exploitation of this reservoir along the Gulf of Suez Basin. In this work, we conduct an integrated study using multidisciplinary datasets and techniques to determine the precise structural, petrophysical, and facies characteristics of the Matulla Formation and predict their complex geometry in 3D space. To complete this study, 30 2D seismic sections, five digital well logs, and core samples of 75 ft (ft = 0.3048 m) length were used to build 3D models for the Matulla reservoir. The 3D structural model shows strong lateral variation in thickness of the Matulla Formation with NW–SE, NE–SW and N–S fault directions. According to the 3D facies model, shale beds dominate the Matulla Formation, followed by sandstone, carbonate, and siltstone beds. The petrophysical model demonstrates the Matulla reservoir's ability to store and produce oil; its upper and lower zones have good quality reservoir, whereas its middle zone is a poor quality reservoir. The most promising areas for hydrocarbon accumulation and production via the Matulla reservoir are located in the central, southeast, and southwest sectors of the oilfield. In this approach, we combined multiple datasets and used the most likely parameters calibrated by core measurements to improve the reservoir modeling of the complex Matulla reservoir. In addition, we reduced many of the common uncertainties associated with the static modeling process, which can be applied elsewhere to gain better understanding of a complex reservoir.
Plant mediated methane efflux from a boreal peatland complex
Authors: Korrensalo A. , Mammarella I. , Alekseychik P. , Vesala T. , Tuittila E-S. 
Published: December 2021

Abstract
Purpose
Aerenchymous plants are an important control for methane efflux from peatlands to the atmosphere, providing a bypass from the anoxic peat and avoiding oxidation in the oxic peat. We aimed to quantify the drivers of aerenchymous peatland species methane transport and the importance of this process for ecosystem-scale methane efflux.

Methods
We measured seasonal and interspecies variation in methane transport rate per gram of plant dry mass at a boreal fen and bog, which were upscaled to ecosystem-scale plant methane transport.

Results
Methane transport rate was better explained by plant species, leaf greenness and area than by environmental variables. Leaves appeared to transport methane even after senescence. Contrary to our expectations, both methane transport rate and the proportion of plant transport were lower in the fen (with greater sedge cover) than in the bog site. At the fen and bog, average methane transport rate was 0.7 and 1.8 mg g−1 d−1, and the proportion of seasonally variable plant transport was 7–41% and 6–90%, respectively. Species-specific differences in methane transport rate were observed at the ecosystem-scale: Scheuchzeria palustris, which accounted for 16% of the aerenchymous leaf area in the fen and displayed the greatest methane transport rate, was responsible for 45% of the ecosystem-scale plant transport.

Conclusion
Our study showed that plant species influence the magnitude of ecosystem-scale methane emissions through their properties of methane transport. The identification and quantification of these properties could be the pivotal next step in predicting plant methane transport in peatlands.