bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of deep learning-based computer aided diagnostic system in improving diagnostic performance of rib fractures in acute blunt trauma
Authors: Tan Hui , Xu Hui , Yu Nan , Yu Yong , Duan Haifeng , Fan Qiuju , Tian Zhanyu 
Published: April 2021

Abstract
Purpose
To evaluate the value of a deep learning-based computer-aided diagnostic system (DL-CAD) in improving the diagnostic performance of acute rib fractures in patients with chest trauma.
Methods
CT images of 214 patients with acute blunt chest trauma were retrospectively analyzed by two interns and two attending radiologists independently firstly and then with the assistance of a DL-CAD one month later, in a blinded and randomized manner. The consensus diagnosis of fib fracture by another two senior thoracic radiologists was regarded as reference standard. The rib fracture diagnostic sensitivity, specificity, positive predictive value, diagnostic confidence and mean reading time with and without DL-CAD were calculated and compared.
Results
There were 680 rib fracture lesions confirmed as reference standard among all patients. The diagnostic sensitivity and positive predictive value of interns were significantly improved from (68.82%, 84.50%) to (91.76%, 93.17%) with the assistance of DL-CAD, respectively. Diagnostic sensitivity and positive predictive value of interns assisted by DL-CAD were comparative to those of attendings aided by DL-CAD (94.56%, 86.47%) or not aided (95.67%, 93.83%), respectively. In addition, when radiologists were assisted by DL-CAD, the mean reading time was significantly reduced and diagnostic confidence was significantly enhanced.
Conclusions
DL-CAD improves the diagnostic performance of acute rib fracture in chest trauma patients, which increases the diagnostic confidence, sensitivity and positive predictive value for radiologists. DC-CAD can advance the diagnostic consistency of radiologists with different experiences.
Down-regulation of SOCS6: An Unfavorable Prognostic Factor for Gastrointestinal Stromal Tumor Proven by Survival Analysis
Authors: Ouyang Jun , An Tailai , Wang Yan , Lu Xiaofang , Zhang Yawei , Wang Xiaokun , Zhang Xinhua , Zhang Changhua 
Published: April 2021

Abstract
Background: Multiple studies reporting that down-regulation of SOCS6 plays vital roles in promoting progression of many tumors have been published. The present study was performed to identify whether SOCS6 was an biomarker significantly associated with prognosis of patients diagnosed with gastrointestinal stromal tumor (GIST). Methods: Immunohistochemical staining was accomplished to evaluate the expression levels of SOCS6 among GIST patients. The impacts of SOCS6 expression on overall survival (OS) and recurrence-free survival (RFS) of GIST patients were assessed by Cox proportional hazard regression model analysis and Kaplan-Meier curve analysis. Results: It was demonstrated that the expression level of SOCS6 was significantly associated with tumor size (P=0.001). Then according to Kaplan-Meier curve analysis, low expression of SOCS6 was significantly correlated with worse OS and RFS of GIST patients. Ultimately, it was revealed by Cox proportional regression model analysis that low expression of SOCS6 was an independent predictive factor for OS and RFS. Conclusion: Low expression of SOCS6 was an independent prognostic factor for GIST, suggesting its potential as a novel biomarker predicting survival of GIST patients.
Green Synthesis ZnO/TiO2 for High Recyclability Rapid Sunlight Photodegradation Textile Dyes Applications
Authors: Rusman Erviani , Heryanto Heryanto , Fahri Ahmad Nurul , Mutmainna Inayatul , Tahir Dahlang 
Published: April 2021

Abstract
Composite ZnO/TiO2 have been successfully synthesized by green synthesis method with various calcination temperature 500oC, 600oC, 700oC, and 800oC (TiO2 concentrations: 2.5 g and 5 g) for photocatalyst application. In this study, Calopogonium mucunoides leaf extract was used as reducing and stabilizing agent. The synthesized composites were characterized by using Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD), and UV-Visible spectroscopy. The XRD spectra shows the hexagonal phase with wurtzite structure of ZnO and anatase for TiO2. The best degradation performance is 98.26% (only 10 min) for ZnO/TiO2 (5 g) with calcination temperature is 800oC. This is due to the highest distance between two optical phonon mode Δ(LO-TO) and lowest attenuating and propagating constant. The composite ZnO/TiO2 shows high potentials photodegradation of organic dyes with the high stable recyclability up to 5 cycles (> 95%) only for every 15 minutes. High potentials for applicability with the concept environmentally friendly principles and stability for circular chemistry, and efficiency of use the energy and chemicals.
Determinants of Antenatal Care Service Satisfaction among Women in Ethiopia: A systematic Review and Meta-Analysis
Authors: Seyoum Kenbon 
Published: April 2021

Abstract
Background: Antenatal care service satisfaction is a measure of the degree to which a woman seeking care is happy with the antenatal care service provided to her. It is important to increase woman utilization of antenatal care service and to improve maternal health. Thus, the aim of this study is to identify factors that determine antenatal care service satisfaction in Ethiopia.Method: PubMed, Hinari, and Google Scholar were systematically searched for eligible studies. The author also conducted gray literature search (e.g., in Google) and hand searched the reference lists of all included studies. All articles reported in the English language irrespective of their duration of publication were included. The Joanna Briggs Institute's (JBI) critical appraisal tools were used to assess the quality of included articles. The Cochrane Q-statistics and I2 tests were used to assess heterogeneity among included studies. Publication bias was assessed using Egger’s tests. Results: Of the 274 articles identified through systematic search of literatures, 13 studies fulfilling inclusion criteria were included in this meta-analysis. First antenatal care visit (AOR = 0.62 and 95% CI: 0.40, 0.96), women waited <60 min (AOR: 1.87 and 95% CI: 1.40-2.50), women whose privacy was maintained (AOR: 3.91 and 95% CI: 1.97-7.77), women treated respectfully (AOR: 5.07 and 95% CI: 2.34-10.96), and unplanned pregnancies (AOR = 0.28 and 95% CI: 0.10-0.77) were significantly associated with antenatal care service satisfaction.Conclusion: The study assessed determinants of antenatal care service satisfaction in Ethiopia. First antenatal care visit, waiting time (<60 min) to see care provider, maintenance of privacy, respectful treatment, and pregnancy unplanned were found to be determinants of antenatal care service satisfaction. Counselling a woman to comply with minimum required antenatal care visit and compassionate and respectful maternity care will increase maternal satisfaction with antenatal care service.
Perceived diet and lifestyle changes during confinement for Covid-19 pandemic in Mexico: ESCAN-COVID19Mx Survey
Authors: Martínez-Vázquez Sophia Eugenia , Ceballos-Rasgado Marena , Posada-Velázquez Rafael , Hunot-Alexander Claudia , Nava-González Edna J , Ramírez-Silva Claudia Ivonne , Aguilar-López Daisy Karina , Quiroz-Olguín Gabriela , López-Jara Beatriz , Cruz Ana Cristina Delgado de la , Huescas-Juárez Sol , Silva-Olvera Mónica Del Rosario , Kaufer-Horwitz Martha 
Published: April 2021

Abstract
Background: Confinement measures that were put in place in Mexico to reduce the transmission of the SARS-CoV-2 virus can affect individual’s lifestyle and well-being; Therefore, the aim of the study was to assess perceived changes in diet quality, emotional eating, physical activity and lifestyle, in a group of Mexican adults before and during the COVID-19 confinement. Methods: 8289 adults answered an online questionnaire between April and May 2020. Data about diet quality, emotional eating, physical activity and sociodemographic characteristics, weight and height were collected. Before and after confinement differences by sociodemographic characteristics were assessed with Wilcoxon, Anova and linear regression analyses. Results: Most participants were women (80%) between 18 and 38 years old (70%), with a low degree of marginalization (82.8%) and a high educational level (84.2%); 53.1% had a normal weight and 31.4% were overweight. Half (46.8%) of the participants perceived a change in the quality of their diet. Lifestyle changes were present among some of the participants, 6.1% stopped smoking, 12.1% stopped consuming alcohol, 53.3% sleep later, 9% became more sedentary, and increased their screen (43%), sitting and lying down time (81.6%). Conclusion: Mexicans staying at home during the COVID-19 confinement, that completed the ESCAN-COVID19Mx Survey, perceived positive changes in the quality of their diet, and smoking and alcohol consumption, but negative changes in the level of physical activity and quality of sleep.
Forma dekretu poszczególnego w kanonicznym porządku prawnym (kan. 51 KPK)
Authors: DZIERŻON GINTER 
Published: April 2021

W zaprezentowanym opracowaniu autor dokonał szczegółowej interpretacji kan. 51 KPK. Przedmiotem jego zainteresowania stały się dwa wątki: kwestia pisemności dekretu oraz problem motywacji tego aktu. Z przeprowadzonych analiz wynika, iż konieczność wydania dekretu w formie pisemnej nie jest oczywistością. Dyspozycja bowiem kan. 51 KPK nie spełnia kryterium określonego w kan. 10 KPK dotyczącego ustaw unieważniających i uniezdalniających. Autor wykazał, iż w kanonicznym porządku prawnym występują regulacje dotyczące pisemności aktów, które spełniają warunki określone w kan. 10 KPK. Taka technika legislacyjna została zastosowana w kan. 474 KPK, zgodnie z którym akta kurii diecezjalnej, aby uzyskać skuteczność prawną do ważności powinny być podpisane przez ordynariusza. W opinii Autora, forma pisemna aktu jest gwarantem pewności i bezpieczeństwa aktów administracyjnych, a także jest konieczna dla celów dowodowych.Obiektem uwagi Autora stał się również problem motywacji dekretu. Stoi on na stanowisku, iż punktu widzenia praktyki administracyjnej najbardziej stosowne byłoby przyjęcie rozwiązania, aby każdy wydawany dekret zawierałby motywację. Tym sposobem bowiem adresat aktu poznałby zarówno racje prawne, jak i faktyczne podjętej decyzji.Wykazał on, iż niewypełnienie wymogu co do motywacji nie skutkuje nieważnością dekretu, ale wiąże się z jego nielegalnością, ponieważ zapis kan. 51 KPK nie spełnia warunków, o których mowa w kan. 10 KPK.
Biomedical Applications of Bacterial Cellulose based Composite Hydrogels
Authors: Liu Wei , Du Haishun , Zheng Ting , Si Chuanling 
Published: April 2021

Background:
Bacterial cellulose (BC) and its derivatives are a rich source of
renewable natural ingredients, which are of great significance for biomedical and medical
applications but have not yet been fully exploited. BC is a high-purity, biocompatible,
and versatile biomaterial that can be used alone or in combination with other ingredients
such as polymers and nanoparticles to provide different structural organization and function.
This review briefly introduces the research status of BC hydrogels, focusing on the
preparation of BC-based composite hydrogels and their applications in the field of
biomedicine, particularly the wound dressings, tissue engineering scaffolds, and drug delivery.

Methods:
By reviewing the most recent literature on this subject, we summarized recent
advances in the preparation of BC-based composite hydrogels and their advances in
biomedical applications, including wound dressings, tissue engineering, and drug delivery.

Results:
BC composite hydrogels have broadened the field of application of BC and developed
a variety of BC-based biomaterials with excellent properties. BC-based hydrogels
have good biocompatibility and broad application prospects in the biomedical field.

Conclusion:
BC-based composite hydrogels with the advantages of 3D structure, nontoxicity,
high purity, and good biocompatibility, have great prospects in the development
of sustainable and multifunctional biomaterials for biomedical applications.
Translational Research of Hemoglobin Vesicles as a Transfusion Alternative
Authors: Sakai Hiromi , Kobayashi Naoko , Kure Tomoko , Okuda Chie 
Published: April 2021

:Clinical situations arise in which blood for transfusion becomes scarce or unavailable. Considerable demand for a transfusion alternative persists because of various difficulties posed by blood donation and transfusion systems. Hemoglobin-vesicles (Hb- V) are artificial oxygen carriers being developed for use as a transfusion alternative. Just as biomembranes of red blood cells (RBCs) do, phospholipid vesicles (liposomes) for Hb encapsulation can protect the human body from the toxic effects of molecular Hb. The main HbV component, Hb, is obtained from discarded human donated blood. Therefore, HbV can be categorized as a biologic agent targeting oxygen for peripheral tissues. The purification procedure strictly eliminates the possibility of viral contamination. It also removes all concomitant unstable enzymes present in RBC for utmost safety from infection. The deoxygenated HbVs, which are storable for over the years at ambient temperature, can function as an alternative to blood transfusion for resuscitation from hemorrhagic shock and O2 therapeutics. Moreover, a recent study clarified beneficial effects for anti- oxidation and anti-inflammation by carbon monoxide (CO)-bound HbVs. Autoxidation of HbV (HbO2 → metHb + O2 -.) is unavoidable after intravenous administration. Co-injection of methylene blue can extract the intraerythrocytic glycolytic electron energy effectively and reduce metHb. Other phenothiazine dyes can also function as electron mediators to improve the functional life span of HbV. This review paper summarizes recent progress of the research and development of HbV, aimed at clinical applications.
A Review of the Synthesis of Nitric Oxide Donor and Donor Derivatives
with Pharmacological Activities
Authors: Wang Kexin , Wang Yue , Zhang Hualin , Li Xintong , Han Weina 
Published: April 2021

:
Endogenous nitric oxide (NO) is an important effector molecule and signal transduction molecule, which participates in the regulation of multiple functions in organisms, involving a variety of physiological and pathological processes, especially playing a very important role in the cardiovascular, immune, and nervous systems. NO is a gaseous substance with a short half-life in the body and is unstable in aqueous solutions. Therefore, many researchers focus on the release and activity of NO donors and their derivatives. However, NO donors can release free NO or NO analogues under physiological conditions to meet the human need. NO donors can be coupled with the corresponding active basic nucleus, so that they have the biological activity derived from both the basic nucleus and the NO donors, thus performing better bioactivity. This paper reviewed the routes of synthesis and advance activities of NO donor derivatives.
Apatinib Inhibits Stem Properties and Malignant Biological Behaviors of Breast Cancer Stem Cells by Blocking Wnt/β-catenin Signal Pathway through Downregulating LncRNA ROR
Authors: Jiang Baohong , Zhu Hongbo , Tang Liting , Gao Ting , Zhou Yu , Gong Fuqiang , Tan Yeru , Xie Liming , Wu Xiaoping , Li Yuehua 
Published: April 2021

Background:
Cancer stem cells could influence tumor recurrence and metastasis.

Objective:
To develop a new effective treatment modality targeting breast cancer stem cells (BCSCs) and to
explore the role of Apatinib in BCSCs.

Methods:
BCSCs were isolated from MDA-MB-231 cells by the immune magnetic beads method. BCSCs were
treated with Apatinib, lentiviral plasmids (lncRNA ROR), and iCRT-3 (Wnt pathway inhibitors). Viability,
colony numbers, sphere numbers, apoptosis, migration, invasion of BCSCs were detected by MTT, colony
formation, tumorsphere, flow cytometry, wound-healing, transwell assays, respectively. The expressions of
markers (ABCG2, CD44, CD90, and CD24), epithelial-mesenchymal transition (EMT)-related molecules (Ecadherin,
N-cadherin, Vimentin, MMP-2, MMP-9), and Wnt/β-catenin pathway-related proteins (Wnt3a, Wnt5a,
β-catenin) in breast cancer stem cells were determined by performing Western blot and qRT-PCR analysis.

Results:
Apatinib decreased the viability and colony numbers of BCSCs in a concentration-dependent manner,
and it also reduced sphere numbers, suppressed migration, invasion and lncRNA ROR expression, and induced
apoptosis of BCSCs. However, these results were partially reversed by lncRNA ROR overexpression. Apatinib
suppressed stem property, EMT process, and Wnt/β-catenin pathway in BCSCs, which was partially reversed by
lncRNA ROR overexpression. Moreover, lncRNA ROR overexpression increased the colony and sphere
numbers and promoted the cell viability, apoptosis inhibition, migration, and invasion of BCSCs, but these
effects were partially reversed by iCRT-3. LncRNA ROR overexpression increased the stem property, EMT
process, and Wnt/β-catenin pathway, which were partially counteracted by iCRT-3.

Conclusion:
Apatinib inhibited stem property and malignant biological behaviors of BCSCs by blocking the
Wnt/β-catenin signal pathway through down-regulating lncRNA ROR.
The Salivary miRNome: A Promising Biomarker of Disease
Authors: Tomei Sara , Manjunath Harshitha Shobha , Murugesan Selvasankar , Al Khodor Souhaila 
Published: April 2021

:
MicroRNAs (miRNAs) are non-coding RNAs ranging from 18-24 nucleotides, also
known to regulate the human genome mainly at the post-transcriptional level. MiRNAs were
shown to play an important role in most biological processes such as apoptosis and in the pathogenesis
of many diseases such as cardiovascular diseases and cancer. Recent developments of advanced
molecular high-throughput technologies have enhanced our knowledge of miRNAs. MiRNAs
can now be discovered, interrogated, and quantified in various body fluids serving as diagnostic
and therapeutic markers for many diseases.

:
While most studies use blood as a sample source to measure circulating miRNAs as possible biomarkers
for disease pathogenesis, fewer studies have assessed the role of salivary miRNAs in
health and disease. This review aims at providing an overview of the current knowledge of the salivary
miRNome, addressing the technical aspects of saliva sampling, and highlighting the applicability
of miRNA screening to clinical practice.
High Expression of miR-483-5p Predicts Chemotherapy Resistance in Epithelial Ovarian Cancer
Authors: Rattanapan Yanisa , Korkiatsakul Veerawat , Kongruang Adcharee , Siriboonpiputtana Teerapong , Rerkamnuaychoke Budsaba , Chareonsirisuthigul Takol 
Published: April 2021

Background:
Ovarian cancer is the most deadly cancer that requires novel diagnostics
and therapeutics. MicroRNAs are viewed as essential gene regulatory elements involved in different
pathobiological mechanisms of many cancers, including ovarian cancer.

Objective:
This study examined the relationship between microRNA (miRNA) expression and response
to platinum-based chemotherapy.

Methods:
Genome-wide miRNA expression analysis was conducted using Epithelial Ovarian Cancer
(EOC) tissues from 25 patients with 17 malignant tumors and eight benign ovarian tumors. Candidate
miRNAs that respond to platinum-based chemotherapy were selected for validation by quantitative
RT-PCR.

Result:
Among 2,578 mature human miRNAs, high expression of miR-483-5p correlated with
poor responses to platinum-based chemotherapy in EOC patients. Furthermore, high levels of
miR-483-5p in the resistant group suppressed expression of the apoptotic regulator TAOK-1.

Conclusion:
A possible marker for the prediction of chemotherapy response and resistance in patients
may be miR-483-5p. Choosing the right treatment for each patient with EOC can avoid the
risk of developing chemotherapy resistance.
Digital Patient-Reported Outcome Measures for Monitoring of Patients on Cancer Treatment: Cross-sectional Questionnaire Study
Authors: Sivanandan Mayuran Ananth , Sharma Catherine , Bullard Pippa , Christian Judith 
Published: April 2021

Background
Oncology has been facing increasing outpatient activity associated with higher cancer incidence, better survival rates, and more treatment options. Innovative technological solutions could help deal with this increasing demand. Using digital patient-reported outcome measures (PROMs) to identify patients who need a face-to-face (FTF) appointment is a potential approach.

Objective
This study aims to assess the feasibility of digital PROM questionnaires to enable remote symptom monitoring for patients undergoing cancer treatment and their ability to highlight the requirement for an FTF appointment.

Methods
This study was performed at a tertiary oncology center between December 2018 and February 2019. The Common Terminology Criteria for Adverse Events were adapted into patient-friendly language to form the basis of treatment-specific digital questionnaires covering specific cancer drugs and radiotherapy treatments. These treatment-specific digital PROM questionnaires were scored by both patients and their clinicians during FTF appointments. Patients and clinicians did not see each other’s scored PROMs. Agreement between patients and clinicians was assessed using descriptive statistics. Patient and staff feedback was also obtained.

Results
In total, 90 patients participated in the study across 10 different treatment pathways. By comparing paired patient and clinician responses, the sensitivity of the patient-completed questionnaires in correctly highlighting the need for FTF review was 94% (44/47), and all patients with severe or grade 3+ symptoms were identified (6/6, 100%). Patient-completed PROMs appropriately revealed that 29% (26/90) of the participating patients did not need FTF review based on their symptoms alone. Certain oncological treatment pathways, such as immunotherapy, were found to have a larger proportion of patients with minimal symptoms than others, such as conventional chemotherapy. Patient and staff feedback showed high approval of digital PROMs and their potential for use in remote monitoring.

Conclusions
Digital PROM questionnaires can feasibly highlight the need for FTF review in oncology clinics for treatment. Their use with specific treatments could safely reduce the requirement for FTF care, and future work should evaluate their application in the remote monitoring of patients.