bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials
Authors: Bhanu Cini , Nimmons Danielle , Petersen Irene , Orlu Mine , Davis Daniel , Hussain Hajra , Magammanage Sanuri , Walters Kate 
Published: November 2021

Background
Drug-induced orthostatic hypotension (OH) is common, and its resulting cerebral hypoperfusion is linked to adverse outcomes including falls, strokes, cognitive impairment, and increased mortality. The extent to which specific medications are associated with OH remains unclear.

Methods and findings
We conducted a systematic review and meta-analysis to evaluate the extent to which specific drug groups are associated with OH. EMBASE, MEDLINE, and Web of Science databases were searched from inception through 23 November 2020. Placebo-controlled randomised controlled trials (RCTs) on any drug reporting on OH as an adverse effect in adults (≥18 years) were eligible. Three authors extracted data on the drug, OH, dose, participant characteristics, and study setting. The revised Cochrane risk-of-bias tool for randomised trials (RoB 2) was used to appraise evidence. Summary odds ratios (ORs) were estimated for OH using fixed effects Mantel–Haenszel statistics. We conducted subgroup analysis on validity of OH measurement, drug dose, risk of bias, age, and comorbidity. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to summarise the certainty of evidence. Of 36,940 citations, 69 eligible RCTs were included in the meta-analysis comprising 27,079 participants. Compared with placebo, beta-blockers and tricyclic antidepressants were associated with increased odds of OH (OR 7.76 [95% CI 2.51, 24.03]; OR 6.30 [95% CI 2.86, 13.91]). Alpha-blockers, antipsychotics, and SGLT-2 inhibitors were associated with up to 2-fold increased odds of OH, compared to placebo. There was no statistically significant difference in odds of OH with vasodilators (CCBs, ACE inhibitors/ARBs, SSRIs), compared to placebo. Limitations of this study are as follows: data limited to placebo-controlled studies, (excluding head-to-head trials), many RCTs excluded older participants; therefore results may be amplified in older patients in the clinical setting. The study protocol is publicly available on PROSPERO (CRD42020168697).

Conclusions
Medications prescribed for common conditions (including depression, diabetes, and lower urinary tract symptoms) were associated with significantly increased odds of OH. Drugs causing sympathetic inhibition were associated with significantly increased odds of OH, while most vasodilators were associated with small nonsignificant differences in odds of OH, compared to placebo. Drugs targeting multiple parts of the orthostatic blood pressure (BP) reflex pathway (e.g. sympathetic inhibition, vasodilation, cardio-inhibitory effects) may carry cumulative risk, suggesting that individuals with polypharmacy could benefit from postural BP monitoring.
Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats
Authors: Nagai Katsuhito , Ryuno Yoshikazu , Iwanami Yoshihito , Omotani Sachiko , Fukuno Shuhei , Hatsuda Yasutoshi , Konishi Hiroki , Myotoku Michiaki 
Published: November 2021

BackgroundThe use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients.AimIn this study, we examined whether the pharmacokinetic profiles of sodium valproate (SVA), levetiracetam (LEV), and carbamazepine (CBZ) are affected by altering the dosing time of RACOL®-NF Semi Solid for Enteral Use (RASS), a prescribed semi-solid formula. We also investigated whether the pharmacokinetic interaction observed in this study can be avoided by staggered dosing of the chemical drug and semi-solid enteral nutrient.MethodsThe plasma concentration of SVA, LEV and CBZ after oral administration was measured by LC-MS/MS method.ResultsThere was no difference in pharmacokinetic characteristics of SVA and LEV when the dosing time of RASS was altered. On the other hand, the plasma concentration of CBZ after oral administration at all sampling points decreased with the extension of the dosing time of RASS, which was consistent with the Cmaxand AUC. However, no significant difference was observed in the pharmacokinetic profiles or parameters of CBZ between the short-term and long-term RASS dosing groups by prolonging the administered interval of CBZ and RASS for 2 hr.ConclusionWe concluded that the pharmacokinetic profiles of CBZ, but not SVA and LEV, after its oral administration are affected by the dosing time of RASS, but staggered administration of CBZ and RASS prevented their interaction.
A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study
Authors: Bawore Solomon Gebre , Adissu Wondimagegn , Niguse Berhanu , Larebo Yilma Markos , Ermolo Nigussie Abebe , Gedefaw Lealem 
Published: November 2021

Introduction
Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting.

Methods
A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant.

Results
A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1).

Conclusions
Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.
From Being to Existence – The Beginning 0f Hegel’s Logic
Authors: De Rosales Chacón Jacinto Rivera 
Published: November 2021

Der Artikel legt dar, was "Anfang" im kreisförmigen System Hegels bedeutet, und untersucht kritisch die ersten Schritte seiner Logik: Sein, Nichts, Werden, Dasein. Die These lautet: das Sein als Sein wird hier in seinem ontologischen Sinne nicht gedacht und ein dialektischer Übergang zwischen Sein und Dasein ist nicht möglich.
The article exposes what "beginning" means in the circular system of Hegel, and critically studies the first steps of his logic: being, nothing, becoming, existence. The thesis is that being as being is not there thought in its ontological sense, and that a dialectical transition between being and existence is not possible.
GOOD GOVERNANCE AND NATURAL RESOURCE CURSE; WHICH HYPOTHESIS IS PREVAILING IN ASEAN ECONOMIES?
Authors: Iskandar Deden , Hendarto Robertus Mulyo , Reza Adhevyo 
Published: November 2021

This study aims to find the relevance of the natural resource curse and good governance hypothesis in ASEAN economies post-financial crises 1998. Employing Generalized Method of Moments (GMM), this study finds that good governance practices (Control of Corruption, Political Stability, and Voice and Accountability) play a role in the ASEAN economies after the great financial crisis. Thus, the hypothesis stating that good governance practices will improve economic development is confirmed. On the other hand, the observation of the natural resource curse hypothesis in ASEAN countries returns mixed results. The hypothesis states that natural resource abundance is associated with lower economic performance. This study finds that dependence on the natural resource by itself does not affect GDP. However, the natural resource curse occurs when countries with bad governance (low Control of Corruption) depend on agriculture resources. On the other hand, the natural resource becomes a blessing when the countries that rely on agriculture resources are supported with good governance practices in terms of strong Government Effectiveness, Political Stability, and Voice and Accountability. Thus, the effect of natural resources on economic development depends on the quality of governance. This paper highlights the importance of observing the natural resource and good governance in interaction instead of in isolation and the relevance of disaggregating the indicators of good governance as well as natural resources.
Performance Prediction Of Production Lines Using Machine Learning Algorithm
Authors: Adesiyan Ayomide Emmanuel 
Published: November 2021

Manufacturing today considers data-drive business operations at different levels leading to the growth of various paradigms in manufacturing, of which emerged smart manufacturing.
However data can be used to predict equipment failure rates, streamline and optimize inventory management and prioritize processes.
The use of parameter tuning and optimization, grid-search, cross-validation, to predict the best performing machine learning algorithm. This research work evaluates the time potential failure-rates, against the lines which peaks and drops depending on its components RUL(Remaining Useful Life). The accuracy of the machine learning algorithms that are employed in this studies, are hence subjected to some metrics for evaluation, these are : MCC and AUC-ROC.
This study has analyzed and evaluated some annoymized dataset from a manufacturing company, using some metrics and machine learning algorithms for performance prediction of their production lines using unsupervised learning. This study would served as a good reference for anyone wanting to use the best performance model, for further research work.
Von der charismatischen Herrschaft zum ‚digital leader‘: Führung im Wandel?
Authors: Elias Friederike , Valarini Elizangela 
Published: November 2021

Zusammenfassung
Im Zuge der digitalen Transformation wird eine grundlegende Veränderung der Organisationsstrukturen von Unternehmen postuliert, die eine schnelle Anpassung an sich wandelnde Umweltanforderungen gewährleisten soll. Im Managementdiskurs werden in diesem Zusammenhang unter dem Label „digital leadership“ oder „agile Führung“ neue Führungskonzepte lanciert. Wir fragen in unserem Beitrag, ob es aktuell tatsächlich zu einer umfassenden Reorganisation der Führungsbeziehung kommt. Auf Basis von 36 Interviews mit Führungskräften aus Industrie- und Dienstleistungsunternehmen haben wir eine wissenssoziologische Deutungsmusteranalyse durchgeführt und deren Ergebnisse einer kritischen Betrachtung unterzogen. Unsere Ergebnisse zeigen eher Kontinuitäten im Führungsverständnis der deutschen ManagerInnen auf als einen grundlegenden Bruch. Vielmehr verstärkt der Digitalisierungsprozess die Durchsetzung des partizipativen Führungsstils – eine Entwicklung, die empirische Studien bis in die frühen 1980er Jahre zurückverfolgt haben.
On (m, P)-expansive operators: products, perturbation by nilpotents, Drazin invertibility
Authors: Duggal B.P. 
Published: November 2021

Abstract
A generalisation of m-expansive Hilbert space operators T ∈ B(ℋ) [18, 20] to Banach space operators T ∈ B(𝒳) is obtained by defining that a pair of operators A, B ∈ B(𝒳) is (m, P)-expansive for some operator P ∈ B(𝒳) if Δ
A,B
m
(P)=

(

I
-

L

A

R

B

)

m

(
P
)

=

∑

j
=
0

m

(

-
1

)

j

(

j
m

)

{\left( {I - {L_A}{R_B}} \right)^m}\left( P \right) = \sum\nolimits_{j = 0}^m {{{\left( { - 1} \right)}^j}\left( {_j^m} \right)}

AjPBj
≤0; LA(X) = AX and RB(X)=XB.
Unlike m-isometric and m-left invertible operators, commuting products and perturbations by commuting nilpotents of (m, I)-expansive operators do not result in expansive operators: using elementary algebraic properties of the left and right multiplication operators, a sufficient condition is proved. For Drazin invertible A and B ∈ B(ℋ), with Drazin inverses Ad and Bd, a sufficient condition proving (Ad, Bd) ^ (A, B) is (m − 1, P)-isometric (resp., (m − 1, P)-contractive) for m even (resp., m odd) is given, and a Banach space analogue of this result is proved.
Deformation of designed steel plates: An optimisation of the side hull structure using the finite element approach
Authors: Prabowo Aditya Rio , Tuswan Tuswan , Prabowoputra Dandun Mahesa , Ridwan Ridwan 
Published: November 2021

Abstract
Thin-walled structures, which generally consist of unstiffened and stiffened plates, are widely used in engineering as one of the core features of any product or construction. Due to environmental conditions and working operation, the components of the structure unavoidably become subject to various types of loading. Deformation patterns and overall behaviour are expected to be varied, as different materials are considered in the structures. In this situation, assessments are required to quantify the responses and determine the relationships between the structural behaviour and structural parameters. In this work, we attempt to obtain the behaviour data of unstiffened and stiffened plates as components of thin-walled structures. The material class – i.e. low- and medium-carbon steels – and loading parameters (i.e. type and angle) are taken as the main inputs in the finite element analysis. A geometrical design is adopted based on the side hull structure of a medium-sized tanker, for which two plate types, unstiffened and stiffened, are used. The results indicate that increasing the loading angle reduces the force experienced by the plate, while the greater the loading direction angle is, the greater the total displacement value will be. In terms of the plate design, the stiffener is observed to reduce the force expansion during the loading of the stiffened plate.
Study on titanium dioxide nanoparticles as MALDI MS matrix for the determination of lipids in the brain
Authors: Peng Congnan , Zhang Qian , Liu Jian-an , Wang Zhen-peng , Zhao Zhen-wen , Kang Ning , Chen Yuxin , Huo Qing 
Published: November 2021

Abstract
The structures of lipids are diverse, and thus, lipids show various biological functions. Systematic determination of lipids in organisms has always been a concern. In this paper, a methodology on the matrix-assisted laser desorption ionization mass spectrometry (MALDI MS), with titanium dioxide nanoparticles (TiO2 NPs) as the matrix, was studied for lipid determination. The results showed that the following conditions were preferable in the determination of small-molecule lipids (such as hypoxanthine, guanosine, uridine, and cytidine), lipid standards (such as GC, GM, TG, phosphatidylethanolamine, phosphatidylcholine, and ceramide), and mixed lipids (extracted from brain homogenate with methanol alone and with the B&D method): TiO2 NPs as the matrix, absolute ethanol as the solvent, 1 mg of TiO2 NPs dispersed in 1 mL of absolute ethanol as the matrix solution, NaCl as the ionization reagent, and positive mass spectrometry (MS) as the mode. Modified TiO2 NP as a new matrix for MALDI MS will be a future research direction; in addition, the characteristics of TiO2 NPs make it a potential matrix for imaging MS.
Prediction model based on chemical composition change for the mechanical degradation of Korean pine (Pinus koraiensis) after brown-rot fungi (Gloeophyllum trabeum) invasion
Authors: Zhang Lipeng , Xie Qifang , Yang Liujie , Wu Yajie , Ma Xingxia 
Published: November 2021

Abstract
In order to predict the mechanical properties of Korean pine after brown-rot decay based on its chemical composition change, 252 samples were prepared and exposed to a 14-week accelerated laboratory decay test using the brown-rot fungus Gloeophyllum trabeum. The mass loss, parallel-to-grain compressive strength, parallel-to-grain tensile strength and bending strengths were tested. Then chemical components and scanning electron micrograph analysis were conducted every two weeks. Results indicated that the mass loss rates of the samples increased with the increasing decay time and were negatively correlated with the sample volume. The strength loss rates were positively correlated with the decay time and mass loss rates. After 14 weeks the average strength loss rates of the parallel-to-grain compressive, tensile and bending samples reached 32%, 41% and 41%, respectively. Strengths degradation was found sensitive to the change of cellulose and hemicellulose contents. Further, mathematical regression models were proposed based on the content changes of the cellulose and hemicellulose to quantitatively predict the degradation of the strengths of Korean pine after brown-rot decay.
Parametric optimization of friction stir processing on micro-hardness of Al/B4C composite
Authors: Kumar Sudhir , Kumar Kapil , Maurya Manish , Vishal  
Published: November 2021

Abstract
Friction stir processing was used to prepare aluminium metal matrix composite reinforced with B4C particles. The micro-hardness of the composite was improved by selecting the process parameters. Friction stir processing parameters, namely tool rotational speed, tool tilt angle and different pin profiles, were explored by using Taguchi’s L9 orthogonal array and analysis of variance. Optical microscopy and scanning electron microscopy were employed for microstructural analysis. X-ray diffraction was used to evaluate the residual stress. Experimental results illustrated that increased rotational speed, reduced tilt angle and square pin profile of the tool gave more uniform dispersal of B4C content with maximum micro-hardness. Small amounts of compressive residual stress developed at the stirred and thermo-mechanically affected zones confirmed the adequate improvement in micro-hardness. Micro-hardness of fabricated Al 6063/B4C composite surfaces was enhanced by 30% as compared to Al 6063 alloy.
Calcium substituted with magnesium, silver and zinc in hydroxyapatite: a review
Authors: Mahanty Anuradha , Shikha Deep 
Published: November 2021

Abstract
Hydroxyapatite with the chemical formula Ca10(-PO4)6(OH)2 is an important bioceramic well known for its high osteoconductive properties, non-toxic nature, high bioactivity and good biocompatibility. Moreover, it is known to mimic natural bone. Inspite of the above mentioned advantages, it has certain disadvantages such as having poor mechanical properties, being brittle, not showing an inhibitory effect on microbes and taking a long time to resorb in the body. These disadvantages can be covered up by the addition of dopants which include cations, anions and polymers. These are sufficiently known to improve the properties of hydroxyapatite. This review focuses on the substitution of hydroxyapatite with silver, zinc, magnesium ions and alloys to show the changes in the morphology and biocompatible properties of hydroxyapatite after substitution of the ions in the matrix.
Composition design, microstructure, and mechanical properties of novel Ti–Co–Ni–Zr complex concentrated alloys
Authors: Wu Junxia , Li Peiyou , Dong Hongfeng , Jia Yuefei , Liu Yaling , Zhang Wei , Zhang Mina 
Published: November 2021

Abstract
The composition design of complex concentrated alloys originates from the composition design of amorphous alloys. To expand the composition design of alloys, herein, the compositions of novel Ti–Co–Ni–Zr complex concentrated alloys were obtained by the proportional mixing of Ti2Co intermetallics and Ni64Zr36 binary eutectic. The theory and method of this new alloy design are also discussed. The as-cast Ti28Co14Ni37.12Zr20.88, Ti30Co15Ni35.2Zr19.8, and Ti32 . Co16Ni33.3Zr18.7 alloys were composed of body-centered cubic TiNi and Ti2Ni phases. The Ti28Co14Ni37.12Zr20.88 alloy exhibited high yield strength (2 164 MPa) and compressive strength (2 539 MPa) under quasi-static compression at roomtemperature. The high strength of Ti28Co14Ni37.12Zr20.88 alloy is related to the precipitation of Ti2Ni along the grain boundary and the precipitation in the crystal. This paper validates that using the proportional mixing method of intermetallics and eutectic alloy is an effective method to design complex concentrated alloys with high strength.
Notstand und Sachverstand
Authors: Middendorf Stefanie 
Published: November 2021

Abstract
In the aftermath of the First World War, the Weimar Republic found itself in financial disarray. Originally put forward by the antirepublican right, the idea of a forced loan emerged. The idea triggered harsh controversies regarding the shortfalls in the new state’s sovereignty and its lack of fiscal power within the framework of an international order. The conflicting images of the Weimar state effected the decisions finally taken. This article argues that a rhetoric of emergency was combined with notions of the expert as an apolitical figure in order to legitimize compulsory lending. Yet, contrary to contemporary perceptions, the Weimar forced loan was not a result of governmental impotence or an exceptional incident within the history of public finance. As a political tool, it helped to solve conflicts on the national as well as the international level, if only for a short period of time. As an instrument of state finance, it was not an act of failure to still fiscal needs the ‚normal way‘ but a conscious claim for the autonomy of the Weimar state. But the conviction that compulsory loans might be a legitimate element of fiscal politics under the auspices of a strong and well-informed state emerged only with the Second World War – in Germany as well as on an international level.