bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation
Authors: Oh Hyeon‐Ji , Park Gwang Yeol , Han Jieun , Son Boram , Han Jun‐Hyeok , Choi Hyomin , Park Chun Gwon , Choi Dong Wook , Park Sung‐Soo , Park Wooram , Park Hee Ho 
Published: December 2024

AbstractPhotodynamic therapy (PDT) is a promising cancer treatment, but its clinical use is limited by nontargeted photosensitizers (PS) that accumulate in normal tissues, causing adverse effects, and poor penetration in tumor tissues due to the dense extracellular matrix (ECM). Here an innovative approach is presented using cell‐derived nanovesicles (CNVs) engineered with chimeric antigen receptor (CAR) and hyaluronidase PH20 to enhance targeted PDT. The CAR–PH20 CNVs, loaded with the photosensitizer pheophorbide a (PheoA), specifically target HER2‐expressing tumor cells and degrade hyaluronic acid in the tumor microenvironment (TME), improving tumor penetration and drug distribution. In vitro and in vivo experiments demonstrate increased reactive oxygen species (ROS) generation, improved tumor retention, and enhanced therapeutic efficacy compared to conventional methods. When combined with laser irradiation, these CNVs induce significant tumor cell apoptosis and inhibit tumor growth in mouse models, while minimizing toxicity to normal tissues. This platform offers a promising strategy for targeted, TME‐modulating PDT with improved efficacy, and reduced side effects, marking a significant advance in nanodrug‐based cancer therapies.
Dual‐Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections
Authors: Li Gangfeng , Feng Zhuoya , Hou Zishuo , Chen Runze , Cui Hannan , Wang Tengjiao , Li Peng 
Published: December 2024

AbstractHydrogen selenide (H2Se) as one of the endogenous gaseous signaling molecules for antibacterial gas therapy, faces limitations such as high‐dose toxicity and short half‐life. Herein, a polymeric H2Se delivery nanogel (H2Se‐NG) incorporated with aldehyde‐modified selenobenzamide (SeAs) is designed for multidrug resistant (MDR) related healthcare‐associated infections (HAIs) treatment. H2Se‐NG facilitates a dual‐cascade responsive release of H2Se over 72 h, effectively addressing the safety issues caused by the rapid hydrolysis of traditional inorganic H2Se delivery methods. In vitro and in vivo studies demonstrate that nontoxic doses of H2Se‐NG at 150 µg mL−1 not only eliminated over 99% of MDR bacteria and their biofilm within 8 h while reducing levels of proinflammatory cytokines postinfection. Additionally, RNA sequencing results reveal that the released H2Se induces oxidative stress at infection site, kills biofilm‐embedded methicillin‐resistant Staphylococcus aureus (MRSA) and leads biofilm elimination by activating biofilm dispersion genes, suggesting the potential of H2Se‐NG as a promising strategy in antibacterial gas therapy.
Heterogeneous Architecture Light‐Responsive Stiffness‐Tunable Magnetic Actuator
Authors: Wu Chao , Li Jiawei , Zhang Qiankun , Kang Hongjun , Xie Zhimin , Cheng Zhongjun , Tao Qiang , Zhang Dongjie , Liu Yuyan 
Published: December 2024

AbstractActuators play important roles in various fields due to their high intelligence. However, the present actuators are hard to achieve high load capacity and easy and fast deformation simultaneously. Here, a novel heterostructure magnetic composite material is proposed, which can work as a matrix to create various actuators by easily tailored and magnetized. Initially, a UV‐responsive stiffness‐tunable polymer (URST‐polymer) is developed using in situ encapsulation of reactive double bonds, achieving a modulus increase of up to 15 600 times after stiffening. By introducing NdFeB@PDA particles into URST‐polymer, the heterostructure matrix is created through a one‐step curing process, which features dual‐functional layers: the layer with NdFeB@PDA particles ensures excellent magnetic actuation properties, while the pure polymer layer guarantees effective UV‐induced stiffening. Consequently, the light‐responsive stiffness‐tunable magnetic actuator (LRST‐MA) made by a heterostructure matrix demonstrates rapid actuation, bistable states, and high stiffness. The URST layer also imparts excellent shape memory properties due to a special polymer network. Combining those advantages with structural and magnetization design, the matrix can be used in applications such as multi‐morphic actuators, variable stiffness grippers, deployable antennas, and emergency robots, which provide a simple and effective strategy for designing actuators.
Critical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond
Authors: Hui Yue , Liu Yun , Yang Guangze , Weng Yilun , Hou Fei , Wang Xing , Fang Sheng , Gao Huajian , Zhao Chun‐Xia 
Published: December 2024

AbstractNanomaterials have become essential in the daily lives, finding applications in food, skincare, drugs, and vaccines. Traditionally, the surface chemistry of nanoparticles (NPs) is considered the key factor in determining their interactions with biological systems. However, recent studies have shown that the mechanical properties of nanomaterials are equally important in regulating nano‐bio interactions, though they have often been overlooked. Tuning the mechanical properties of nanomaterials and designing them for biomedical applications is thus crucial. This review begins by discussing the various mechanical cues in biological processes, including how viruses and cells adjust their mechanical properties throughout their life cycles. Basic concepts and terminology related to NP mechanical properties are introduced. Next, five different groups of nanomaterials with tunable mechanical properties are explored. The review then examines the impact of NP mechanical properties on their interactions in vitro and in vivo, covering tumor‐targeted drug delivery, nanovaccines, and emerging applications such as oral and intranasal drug delivery. Current challenges in the field and perspectives on future developments are also provided.
Bioinspired Heterogeneous Surface for Radiative Cooling Enhanced Power‐Free Moisture Harvesting in Unsaturated Atmosphere
Authors: Zhang Congyuan , Xie Heng , Du Yu , Wu Ting , Wang Zuankai , Qu Jinping 
Published: December 2024

AbstractThe development of zero‐power moisture‐harvesting technology in an unsaturated atmosphere is of great significance for coping with global freshwater scarcity. Here, inspired by Pachydactylus rangei's (Namib sand gecko) ability to evade thermal radiation and harvest moisture, a power‐free cooling moisture harvester (PFCMH) is fabricated using the continuous, industrialized micro‐extrusion compression molding. A Luneburg lens is introduced in the PFCMH for the first time, endowing it with a high reflectivity of ≈92.9% in 0.3 to the 2.5 µm waveband and emissivity of ≈98.1% in 8–13 µm waveband, which are ≈19.2% and ≈15.4% higher than those of the unstructured radiative cooler, respectively. Consequently, a temperature reduction of ≈6.9 °C is achieved. In addition, the wettability of PFCMH is well regulated, at a contact angle of ≈153° and a rolling angle of ≈42°, enabling its surface to efficiently nucleate and transport water droplets. The synergy between the surface and interface functions endows the PFCMH with exceptional passive sub‐dewpoint cooling and efficient harvesting performance. Importantly, every 1 m2 of PFCMH can yield ≈294.5–490.6 kg year−1 of water and save ≈198.7–331.0 kWh year−1 of electricity. The PFCMH offers an environmentally, power‐free, and promising solution to freshwater scarcity.
Stabilizing the Fe Species of Nickel‐Iron Double Hydroxide via Chelating Asymmetric Aldehyde‐Containing THB Ligand for Long‐Lasting Water Oxidation
Authors: Huang Yifan , Kong Fantao , Yu Xu , Yang Tao , Wu Ping , Shen Ruxiang , Zhuo Shangjun , Cui Xiangzhi , Shi Jianlin 
Published: December 2024

AbstractNickel‐iron layered double hydroxides (NiFe LDHs) are considered as promising substitutes for precious metals in oxygen evolution reaction (OER). However, most of the reported NiFe LDHs suffer from poor long‐term stability because of the Fe loss during OER resulting in severe inactivation. Herein, a dynamically stable chelating interface through in situ transformation of asymmetric aldehyde‐ligand (THB, 1,3,5‐Tris(3′‐hydroxy‐4′‐formylphenyl)‐benzene) modified NiFe LDHs to anchor Fe and significantly enhance the OER stability is reported. The fabricated asymmetric aldehyde‐containing ligand THB is capable of stimulating much more interfacial charge transfer from NiFe LDHs to the oxygen group of THB and accelerating the formation of highly valent active Fe species leading to the strong combination between Fe and ligand and the reduced activation energy barrier of the intermediate, respectively. The optimized aldehyde‐ligand‐chelated NiFe LDHs (NiFe LDH/THB) shows enhanced OER performance featuring an overpotential of 224 mV at 100 mA cm−2 and robust stability for over 3860 h at 100 mA cm−2 in a water splitting device maintaining a cell voltage of only 1.68 V, which paves a new avenue to improve the water electrolysis performance of non‐noble metal catalysts.
Wireless Printed Large‐Area Sensors for Continuous Structural Health Monitoring
Authors: Hassan Md Farhad , Li Zijie , Islam Mohammad Shafiqul , Gencturk Bora , Zheng Botong , Pan Xiaoying , Khan Yasser , Muin Sifat 
Published: December 2024

AbstractStructural health monitoring (SHM) is critical to the continuous safety assessment of infrastructure components, particularly for those with concerns over aging and structural deterioration. Traditional strain sensors in SHM often face limitations in sensitivity, durability, and scalability, particularly for large‐area monitoring. In this work, these challenges are addressed by introducing a digitally fabricated strain sensor using additive 3D direct writing technology. The sensor uses a hybrid structure of stretchable carbon and silver materials to improve sensitivity and durability. It achieves dual‐axis strain sensing by positioning carbon elements in both horizontal and vertical directions, enabling 2D strain mapping. A temperature sensor with nickel oxide nanoparticles provides temperature compensation, ensuring accurate strain measurements. To optimize performance, design parameters are fine‐tuned, and comprehensive tests—including static, dynamic, and tensile strength evaluations are performed. The sensor, measuring 5 cm in length and 0.8 mm in width, reaches a maximum gauge factor of 2.45 at room temperature and shows minimal resistance change (0.01%) after 1000 bending cycles with a 5 mm radius. It detects small deformations with a resolution of 0.05%, and dynamic tests, such as earthquake simulations, verify its stability. Tensile testing, using a dynamic servohydraulic Material Testing System (MTS) frame for tension/compression, validates the accuracy of the sensor. This research advances SHM technology by offering a novel digital manufacturing approach for dual‐axis strain sensing, demonstrating the potential of the sensor for continuous, low‐cost, large‐area monitoring.
In Silico Study on the Geometry of Thermal Transducers in Magnetothermal Stimulation
Authors: Midler Noy , Kuznetsova Ekaterina , Shalom Shahar , Begmatova Dilorom , Rosenfeld Dekel 
Published: December 2024

AbstractHyperthermia therapy involves the controlled elevation of tissue temperature. It holds promise as a therapeutic modality for various medical applications, including tissue ablation and the activation of thermosensitive cellular mechanisms. This study leverages finite element modeling (FEM) of nanomaterial‐mediated hyperthermia to optimize the geometry of the heat source within the tissue, with the goal of maximizing temperature distribution in solid and hollow organs, tailored for activation of heat‐sensitive ion channels while aspiring to minimize tissue damage or ablation. The models consider physiological factors, such as surrounding fat tissues, vascularization, and fluids, and are developed to match rodent experiments with a scale‐up to human scale organs. The two examined heat source configurations are direct injection of droplets of magnetic nanoparticles versus attached heat‐generating magnetic transducers. The externally attached heat sources prove more effective at achieving therapeutic temperatures with minimal invasiveness, particularly in hollow organs. Furthermore, the simulations demonstrate the importance of heat source volume and density for uniform temperature distribution and reduced tissue damage. Human‐scale models demonstrate the heat source and stimulation duration required for hyperthermia in organs. The suggested model is verified experimentally to match electrogenic cell modulation via heat‐sensitive receptors, paving the way for more precise and safer treatments.
Inhibition of CDH11 Activates cGAS‐STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma
Authors: Li Rui‐Feng , Liu Shuo , Gao Qian , Fu Min , Sun Xin‐Yi , Xiao Mian , Ge Xi‐Yuan , Peng Xin 
Published: December 2024

AbstractSalivary adenoid cystic carcinoma (SACC) is an intractable malignant tumor originates in the secretory glands and frequently metastasizes to the lungs. Hybrid epithelial‐mesenchymal transition (EMT) cells within the tumors are correlated with augmented proliferative capacity and facilitation of lung metastasis. Single‐cell RNA sequencing and spatial transcriptomic sequencing are employed to reveal the hybrid EMT subsets within the vascular fibroblast microenvironment. These hybrid EMT cells exhibit a pro‐tumorigenic impact in vitro. Notably, cadherin 11 (CDH11), a specific marker for hybrid EMT cells, may exert its regulatory role in cellular function by interfering with branched‐chain amino acids (BCAA) metabolism by inhibiting branched‐chain ketoacid dehydrogenase to activate the mammalian target of the rapamycin pathway, thus making it a potential therapeutic target for SACC. Furthermore, celecoxib and its derivatives are specific CDH11 inhibitors that regulate BCAA metabolism, increase reactive oxygen species production, and subsequently activate the cyclic GMP‐AMP synthase‐stimulator of the interferongene pathway (cGAS‐STING). They also inhibit lung metastasis in NOD‐SCID mice in vivo. Overall, these findings suggest a promising treatment strategy that targets hybrid EMT cells to mitigate lung metastasis in SACC. Celecoxib may serve as a promising clinical intervention for the treatment of lung metastases in patients with SACC.
Toward Green Liquid Nitrogen Fertilizer Synthesis: Plasma‐Driven Nitrogen Oxidation and Partial Electrocatalytic Reduction
Authors: Qu Zhongping , Hong Jungmi , Gao Yuting , Sun Jing , Huang Jingwen , Zhang Mingyan , Zhu Mengying , Li Tianyu , Wang Xiangyu , Gan Dingwei , Song Qiang , Zhang Tianqi , Zhou Rusen , Liu Dingxin , Cullen Patrick J. , Zhou Renwu 
Published: December 2024

AbstractLiquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NH4NO3) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air‐to‐NOx‐to‐NH4NO3 pathway for synthesizing liquid nitrogen fertilizer. The process employs an underwater multi‐bubble plasma reactor powered by nanosecond pulse to generate aqueous NOx, which is then partially reduced to NH4NO3 through electrocatalysis. Results show that the highest NOx production rate, 786.5 mol h−1, is achieved when the N2/O2 ratio closely resemble that of air, and short pulse rise/fall times significantly increase NOx yield. Further plasma diagnostic and global plasma chemistry modeling indicate that short rise/fall times facilitate simultaneous dielectric barrier discharge and spark discharge, synergistically enhancing nitrogen fixation efficiency. The partially electro‐reduced liquid NH4NO3 fertilizer significantly improves plant growth, with stem length and leaf length increasing by 91.26% and 54.72%, respectively. Cost estimation reveals that 44.22% of the production cost is attributed to electricity consumption, underscoring the potential for optimization with renewable energy integration. Overall, the study provides new insight for the sustainable production and in‐place utilization of liquid nitrogen fertilizers which may advance sustainable agriculture.
Specific Monitoring the DNA Helicase Function via Anchor‐Embedded DNA Probe
Authors: Ning Keni , Tang Xiaoyan , Li Zhe , Zhong Liting , Zhou Yingchen , Wang Jiaen , Huang Wanyi , Zhang Han , Ke Jiajun , Luan Tiangang , Chen Shuo‐Bin , Zhai Junqiu 
Published: December 2024

AbstractDNA helicases play a pivotal role in maintaining genome integrity by unwinding the DNA double helix and are often considered promising targets for drug development. However, assessing specific DNA helicase activity in living cells remains challenging. Herein, the first anchor‐embedded duplex (ATED) probe, 17GC, is constructed to uniquely monitor the unwinding activity of Werner syndrome helicase (WRN), a clinical anticancer target. This probe integrates biophysical screening and molecular simulation approaches. The 17GC probe consists of two components: the first one is a bubble structure as an anchor for recruiting WRN in cells, and the second one is GC‐rich double helices on both ends of the bubble, which allow high sensitivity in detecting WRN activity. In vitro evaluations demonstrate that 17GC is highly sensitive and specific to WRN (LOD = 33.5 pm) compared to a wide range of other enzymes, including helicases and nucleases. Cellular evaluation reveals that the ATED probe exhibits remarkable performance in monitoring WRN helicase activity and assessing the inhibitory efficiency of clinical WRN inhibitors in various cell types. This study introduces a novel approach for designing specific and sensitive probes for DNA helicases in cells, which holds promise for biological characterization and drug development.
Ferritin‐Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor‐Targeted Therapy
Authors: Zhang Baoli , Yang Libin , Jin Yiliang , Lu Yicheng , Li Jianru , Tang Guoheng , Liu Yang , Huo Jiawei , Xu Ran , Wang Chunru , Yan Xiyun , Li Jie , Fan Kelong 
Published: December 2024

AbstractOwing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, their in vivo applications are severely limited due to cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, to develop a novel supramolecular assembly drug delivery system. Specifically, tetra[4‐(amino)piperidin‐1‐yl]‐C60 (TAPC) is selected as the representative aminated fullerene, and a layer‐by‐layer assembly strategy is designed to controllably assemble TAPC with the negatively charged HFn into a hierarchical coassembly (H@T@H) via electrostatic interactions and hydrogen bonds. In this ordered multilayer structure, the surface displayed HFn endows the inner TAPC with biocompatibility, tumor‐targeting and blood‐brain barrier crossing ability. Additionally, the electrostatic assembly mode enables the acid‐responsive disassembly of H@T@H to release TAPC in lysosomes. In the orthotopic glioma mouse model, the HFn‐assembled TAPC (H@T@H) shows higher brain accumulation and a stronger inhibitory effect on glioma than polyethylene glycol (PEG)‐coated TAPC. Moreover, in an experimental metastasis mouse model, H@T@H have significant preventive and therapeutic effects on tumor metastasis. Encouragingly, the ferritin‐based supramolecular assembly strategy has been proven to have broad applicability for various aminated fullerene derivatives, showing promising potential for tackling the in vivo delivery challenges of cationic drugs.
Redox‐active Co(II) and Zn(II) Pincer Complexes as High‐Capacity Anode Materials for Lithium‐Ion Batteries
Authors: Seong Honggyu , Moon Joon Ha , Jin Youngho , Kim Geongil , Jung Taejung , Yoo Hyerin , Lee Woonghee , Lee Kyounghoon , Cho Se Youn , Choi Jaewon 
Published: December 2024

AbstractTo address the ongoing demand for high‐performance energy storage devices, it is crucial to identify new electrode materials. Lithium‐ion batteries (LIBs) store energy via the electrochemical redox process, so their electrode materials should have reversible redox properties for rechargeability. On that note, redox‐active metal complexes are explored as innovative electrode materials for LIBs. Redox‐active metal(II) chloride complexes (MCC) demonstrate promising potential as anode materials, exhibiting high capacity and excellent rate capability. In particular, zinc(II) chloride complexes, referred to as ZCC, achieve a capacity of 1720 mAh g−1 at 2.0 A g−1 over 200 cycles. Additionally, the lithium‐ion storage mechanism of MCC is elucidated using ex situ analyses of MCC anode's surface in its fully discharged state. The high capacity of the MCC anode is attributed to conversion reaction with Li+ ions forming LiCl and electrodeposition of metallic lithium from the over‐lithiated Li+ ions. These findings support the potential use of redox‐active metal complexes as novel anode materials for LIBs.
On farm soil health assessment across seven sub‐tropical cover crop management systems
Authors: Jesmin Tanjila , Amgain Naba R. , Rabbany Abul , Manirakiza Noel , Capasso Jay , Korus Kevin , Bhadha Jehangir H. 
Published: December 2024

AbstractThe integration of cover cropping in conventional farming systems has shown positive impacts on soil health enhancement. In Florida, where concerns persist about low productivity in mineral soils and significant carbon loss from organic soils, farmers are increasingly adopting cover crops in their routines. This collaborative study aimed to evaluate the immediate effects of cover cropping, comprehend the connections between soil health indicators, and measure quality indices for both mineral and organic soils. Across Florida, we conducted a comprehensive on‐farm study, gathering 272 samples from both mineral and organic surface soils, which were treated with winter or summer cover cropping, rice cultivation, and fallow or flooded fallow. After analyzing 12 health indicators, we employed statistical methods such as mean comparison, non‐parametric correlation, and regression for both pre‐ and post‐cover cropping periods. A modified Comprehensive Assessment of Soil Health scoring system was utilized to assess the quality indices of both soil types. Notably, cover cropping enhanced cation exchange capacity (CEC) and soil protein (SP) in organic soil while preserving an unchanged active carbon (AC) pool. In mineral soils, such practices improved CEC, organic matter, maximum water holding capacity, SP, and total Kjeldahl nitrogen while reducing bulk density and AC. Following cover cropping, correlations among indicators became more pronounced, emphasizing the intricate relationships among soil properties and essential nutrients. Despite this alteration, the health indices did not change in both soils after cover cropping. The study's confined duration, limited to a single cover crop season, may account for the observed impact.