bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Composites From Iron-chelating Pyridine Nitrogen-rich Coordinated Nanosheets for Oxygen Reduction
Authors: Zhang Bing , Guo Hele , Zhang Longsheng , Zhang Xu , Zhang Chao , Liu Tianxi 
Published: December 2021

Abstract
The exploration of a noble-metal-free and nitrogen-doped carbon (M-N/C) composite electrocatalyst for the oxygen reduction reaction (ORR) remains a great challenge. The activities of the M-N/C composite electrocatalysts are mainly affected by the metal active sites, pyridinic nitrogen, and graphitic nitrogen. In the present work, the iron-coordinated self-assembly is proposed for the preparation of iron-chelating pyridine nitrogen-rich coordinated nanosheet (IPNCN) composites as an electrocatalyst. Due to the highly conjugated structure of the IPNCN precursor, the pyridine nitrogen elements at both ends of the tetrapyrido [3,2-a:2',3'-c:3'',2''-h:2''',3'''-j] phenazine (TP) provide the multiple ligands, and the coordination interactions between the irons and the pyridine nitrogen further improve the thermodynamic stability, where the metal active sites and nitrogen elements are uniformly distributed in the whole structure. The resultant IPNCN composites exhibit excellent ORR performance with an onset potential of 0.93 V and a half potential of 0.84 V. Furthermore, the IPNCN composite electrocatalysts show the higher methanol resistance and electrochemical durability than the commercial Pt/C catalysts. It could be convinced that the as-designed IPNCN composite catalysts would be a promising alternative to the noble metal Pt-based catalysts in the practical applications.
Inequalities In Caries Among Pre-School Italian Children With Different Background
Authors: Campus Guglielmo , Cocco Fabio , Strohmenger Laura , Wolf Thomas Gerhard , Balian Araxi , Arghittu Antonella , Cagetti Maria Grazia 
Published: December 2021

Abstract
Background: The study was aimed to describe caries prevalence and severity and health inequalities among Italian preschool children with European and non-European background and to explore the potential presence of a social gradient. Methods: The ICDAS (International Caries Detection and Assessment System) was recorded at school on 6,825 children (52.76% females). Caries frequency and severity was expressed as a proportion, recording the most severe ICDAS score observed. Socioeconomic status (SES) and behavioral habits of children/parents/caregivers were estimated by mean a standardized self-submitted questionnaire filled-in by parents. The Slope Index of Inequality (SII) based on regression of the mid-point value of caries experiences score for each SES group was calculated and a social gradient was generated as the weighted sum of the worst circumstances deriving from social explanatory variables. Children were stratified into four social gradient levels based on the number of worst options. Multivariate regression models (Zero-Inflated Negative Binomial logistic regression in children with European background and a logistic regression in children with non-European background) were used to elucidate the associations between all explanatory variables and health outcome (namely the caries prevalence). Mantel Haenszel trend of odds adjusted by immigrant background and area of living were calculated to study the existence, dimensions and direction of a social gradient in oral health. Results: Overall, 54.37% (95%CI 46.71–58.28%) of the children were caries-free; caries prevalence was statistically significant higher in children with non-European background compared to European children (72.59% vs 41.62% p<0.01). A statistically significant trend was observed for ICDAS 5/6 score and the worst social/behavioral level (Z=5.24, p<0.01). Conclusions: Data show how caries in preschool children is an unsolved public health problem especially in those with a non-European background. The proposed gradient was clearly able to identify children with the worst dental conditions.
Abnormal Methylation of SF-1 Gene Promoter Region in Endometrial Cancer and Its Mechanism
Authors: Huang Zhen , Jia Mingzhu , Jiang Peng , Deng Ying , Ding Shanshan , Lai Li , Hu Yicheng , Hu Zhuoying 
Published: December 2021

Abstract
We aim to investigate the methylation status, protein expression and clinical significance of the steroidogenic factor-1(SF-1) in endometrial carcinoma (EC), and explore the effect of abnormal methylation of SF-1 on the biological behaviour of EC. Bisulfite sequencing (BSP), western blotting (WB), and immunohistochemical were used to detect the methylation status and protein expression of SF-1 in EC tissues, paracancerous tissues and normal endometrial tissues. DNA methyltransferase inhibitor 5-Aza-CdR were used to treat HEC-1-A cell lines to demethylate SF-1. After treatment, WB and qPCR were used to detect the expression of SF-1 and its downstream target genes. Cell proliferation and apoptosis were detected by the EdU fluorescent labelling method and flow cytometry between the groups. Compared with paracancerous tissues and normal endometrial tissues, the expression of SF-1 protein in EC tissues was significantly increased (P﹤0.05). The percentage of methylated cytosine in the promoter region of the SF-1 gene in EC tissues (8.2%) was significantly lower than that in paracancerous tissues by 40.9% (P<0.05). Compared with the control group, after 5-Aza-CdR treatment, the methylation level of the SF-1 gene was significantly reduced (P﹤0.05), the expressions of SF-1 and its downstream target genes were significantly increased (P <0.05), the cell proliferation was enhanced and the cell apoptosis was significantly reduced (P <0.05). In conclusion, in EC, SF-1 gene was hypomethylated and the expression of SF-1 was increased, which promotes cell proliferation and inhibits cell apoptosis. SF-1 may become a new molecular target for early diagnosis and treatment in EC.
Hemicortical Resection and Biological Reconstruction using Allograft for Parosteal Osteosarcoma of the Distal Femur. A Case Series
Authors: Savvidou Olga D , Goumenos Stavros , Trikoupis Ioannis , Kaspiris Angelos , Melissaridou Dimitra , Gavriil Panagiotis , Georgoulis Jimmy , Papagelopoulos Panayiotis J 
Published: December 2021

Abstract
Background: Parosteal osteosarcoma (PAO), which is a surface osteosarcoma, can be treated with wide excision and endoprosthetic or allograft application. However, due to the low local recurrence and metastasis rate, when it appears in the posterior surface of the distal femur, can be managed with hemicortical wide resection and biological reconstruction with hemicortical allograft.The purpose of this study was to evaluate the oncological and functional outcomes of patients with parosteal osteosarcoma (PAO) of the posterior cortex of the distal femur who underwent biological reconstruction after hemicortical resection. Methods: Eleven patients who underwent wide tumor resection and defect reconstruction of the posterior surface of the distal femur using hemicortical allograft were studied retrospectively. Local recurrence, metastasis, complications and the functional outcome using the Musculoskeletal Tumor Society scoring system (MSTS Score) were evaluated.Results: The average postoperative follow-up period was 53.64 months (range, 30 to 84 months). At the latest follow up, all patients were free of the disease without appearing any metastases. A patient with local recurrence underwent revision surgery with fibula autograft reconstruction. The mean MSTS score was 93.45 ± 3.56. Conclusions: In patients with PAO of the posterior aspect of the distal femur the treatment of hemicortical resection and allograft reconstruction has satisfactory oncological and functional outcomes and low complication rates.
Staff-to-Residence Abuse in Nursing Homes: A Scoping Review
Authors: Hirt Julian , Adlbrecht Laura , Heinrich Steffen , Zeller Adelheid 
Published: December 2021

Abstract
Background: Elder abuse in long-term care is an important public health concern with social, health-related, and economic implications. Staff-to-resident abuse is of particular interest since institutions should protect residents’ rights and prevent harm. To provide an up-to date comprehensive overview of staff-to-resident abuse in nursing homes, we performed a scoping review considering types of abuse, their prevalence and associated factors, descriptions, experiences, and preventive interventions.Methods: We performed a scoping review following the framework provided by Arksey and O’Malley. We searched MEDLINE (via PubMed), CINAHL, PsycINFO via Ovid, and Cochrane Library. Additionally, we performed free web searching using Google Scholar and checked relevant reviews. Two reviewers independently selected studies. We narratively synthesised the results.Results: Out of 3876 references retrieved by our search, we included 46 studies in 47 reports. The prevalence rates of abuse varied widely, ranging from 0 to 93% depending on the type of abuse. Associated factors of abuse at the staff, resident, and nursing home level were evaluated inconsistently. Abuse was perceived ambiguous: even though it was considered unacceptable, it was underreported. We found only four studies addressing preventive interventions. Of these, four made recommendations for intervention development. Only one study with an experimental design examined a multi-component intervention including education and mutual support.Conclusions: The review yielded heterogenous evidence not allowing a concrete conclusion on prevalence and associated factors. However, the results show the significance of the problem and indicate that there are associate factors of abuse that can be influenced by appropriate interventions. These are amongst other staff education, organisational culture, and conditions. Further research should investigate the composition and content of preventive interventions and their potential to reduce abusive behaviours.
Correlation Analysis Between Uric Acid and Metabolic Syndrome in the Elderly Population
Authors: Nie Guqiao , Wan Jing Jing , Jiang Lei , Hou Shu Kai , Peng Wen 
Published: December 2021

Abstract
Background：The prevalence of metabolic syndrome in the elderly is gradually increasing，which accounts for the largest burden of non-communicable diseases worldwide and has direct effects on health. Research on the relationship between uric acid and metabolic syndrome in the elderly is relatively lacking. The purpose of this study is to explore the diagnostic value of uric acid levels for metabolic syndrome, compared to other components of metabolic syndrome.Materials and methods：We collected the physical examination data of 1,267 elderly people in the community in Wuhan, and used SPSS IBM 22.0 for data analysis. Perform correlation analysis, logistic regression analysis and draw ROC curve. Results：The prevalence of hyperuricemia was 28.1%, and metabolic syndrome was 18.6%; the uric acid level of the non-metabolic syndrome group was lower than that of the metabolic syndrome group (337.31 vs 381.91 µmol/ L; P<0.05); Pearson analysis revealed uric acid levels are correlated with blood pressure, BMI, triglyceride, high-density lipoprotein cholesterol. Logistic regression analysis results suggest that uric acid is a risk factor for metabolic syndrome. Metabolic syndrome components TG and HDL levels are also related to uric acid levels. The result is described as OR value and 95% CI (OR 1.003 [1.001, 1.005]). By drawing the ROC curve, we found that the area under the curve for uric acid to diagnose metabolic syndrome is 0.64 (sensitivity: 79.3%, specificity: 45.1%), which is similar to other components of metabolic syndrome. Conclusion：We confirmed the correlation between uric acid levels and metabolic syndrome in the elderly Chinese population.
Assessment of Compliance to Animal Source Foods Quality and Safety Standards in Uganda. A Case of Kampala and Mbarara Districts
Authors: Kungu Joseph M , Ejobi Francis , Atuheire Collins , Baluka Sylivia , Kiganira Dan Brian , Namyalo Edity , Meeme Rehema , Okuyo Bosco A 
Published: December 2021

Abstract
Animal source foods (ASFs) can be sources of illness when poorly handled both at the farms and during processing. Efforts have been undertaken by government to promote good food standards, quality and safety but have not paid off due to limited holistic involvement of all ASFs value chain actors like the farmers, transporters, traders, and the consumers. An assessment was conducted in Kampala and Mbarara districts to determine the level of compliance to existing food control standards.The findings are to help inform policies to adapt, promote and implement standards and quality of ASF products free or with minimal contamination, services to promote local industries and protect consumers as well as facilitate access to international markets. This assessment was carried out in Kampala and Mbarara district with major objective of mapping various institutions involved in designing and implementing food control standards with the core mandate lying with Uganda National Bureau of Standards and assessing of compliance to food control standards along the ASFs value chain.The studies were conducted in Kampala, Uganda’s capital and Mbarara, the second biggest city in the country. These districts constitute the major market hub of agricultural products due to their high consumer population. The ASFs value chain assessments were conducted through workshops using focus group discussions with stakeholders in the meat, milk, poultry and fish value chains.A number of organisations along the food chain were involved in designing and implementing of food safety standards and regulations, as well as regulatory norms for setting and controlling of quality standards for animal source foods in Uganda. These included; farmers, transporters, processors, academia, researchers, trade organisations, government institutions, private organisations, international bodies and consumers’ organisations.Majority of the outlet operators had both operating certificates and health certificates, however the remaining proportion that was noncompliant is still significant considering that they still distribute ASFs products. The study also observed that most of the measures required to ensure safety of ASFs are not followed along the food chain such as; poor transportation of animals and their products and use of antibiotics in animal feeds. It was also observed that product quality and cost of the product greatly contribute to the consumers’ demand and confidence for a particular animal source product.
Multi-timescale control of Southern Ocean diapycnal mixing over Atlantic tracer budgets
Authors: Ellison Elizabeth , Mashayekh Ali , Cimolo Laura 
Published: December 2021

Abstract
Oceanic cross-density (diapycnal) mixing helps sustain the ocean den- sity stratification and its Meridional Overturning Circulation (MOC) and is key to global tracer distributions. The Southern Ocean (SO) is a key region where different overturning cells connect, allowing nutri- ent and carbon rich Indian and Pacific deep waters, and oxygen rich Atlantic deep waters to resurface. The SO is also rife with localized intense diapycnal mixing due to breaking of internal waves induced by the interaction of energetic eddies and currents with rough topogra- phy. SO diapycnal mixing is believed to be of secondary importance for the MOC. Here we show that changes to SO mixing can cause sig- nificant alterations to Atlantic biogeochemical tracer distributions over short and long timescales in an idealized model of the MOC. While such alterations are dominated by the direct impact of changes in diapycnal mixing on tracer fluxes on annual to decadal timescales, on centennial timescales they are dominated by the mixing-induced variations in the advective transport of the tracers by the Atlantic MOC. This work sug- gests that an accurate representation of spatio-temporally variable local and non-local mixing processes in the SO is essential for climate mod- els’ ability to i) simulate the biogeochemical cycles and air sea carbon fluxes on decadal timescales, ii) represent the indirect impact of mixing- induced changes to MOC on biogeochemical cycles on longer timescales.
Meta-analysis of genetic association studies on gestational diabetes mellitus
Authors: BHUSHAN Ravi , Upadhyay Sonal , AWASTHI Shally , Panday Monika 
Published: December 2021

Abstract
Background

Several molecular epidemiological studies have analyzed the associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, all these studies suffer from inconsistent and conflicting results owing to relatively smaller sample sizes, fewer genetic variants included in the research, and limited statistical power. Hence, a coherent review and meta-analysis were carried out to provide a quantitative summary related to the associations of commonly studied SNPs with GDM risk.
Methods

Eligible studies were retrieved from PubMed,updated on Dec. 2019. Based on several inclusion and exclusion criteria, 71 articles with 42928 GDM patients and 77793 controls were finally considered for meta-analysis. The genotype data from 23 variants of sixteen genes were statistically analyzed using RevMan v 5.2 software. Newcastle-Ottawa Scale (NOS) was used to assess the quality of the research article. Heterogeneity among studies was tested by I2 and odds ratio with 95% confidence interval (CI) was carried out for all five genetic models.
Results

The overall combined odds ratio reveals that variants like MTNR1B (rs1083963, rs1387153), GCK (rs1799884), CANP10 (rs3792267), and GCKR (rs780094) are significantly associated with GDM in all genetic models while CANP10 (rs5030952), ADRB (rs4994) and FTO (rs8050136) are not significantly associated with GDM in any genetic models. Variants MTNR1B (rs1083963, rs1387153) and GCK (rs1799884) are associated with increased risk (OR>1, p<0.05) of GDM, and all these are related to insulin secretion. Other variants related to insulin secretion like TCF7L2 (rs7903146) and SLC30A8 (rs1326634) are also associated with increased risk (OR>1, p<0.05) of GDM. On the contrary, CANP10 (rs3792267) and GCKR (rs780094) are found associated with decreased risk (OR<1, p<0.05) of GDM. Other variants are significantly associated with the GDM in at least one or more genetic models.
Conclusion

Our study identified that most of the variants related to insulin secretions like MTNR1B (rs1083963), GCK (rs1799884), TCF7L2 (rs7903146), GCKR (rs780094), and SLC30A8 (rs1326634) are more strongly associated (p<0.005) with GDM as compared to the variants related to the insulin resistance like PPARG (rs1801282), IRS1 (rs1801278) and ADIPOQ (rs266729).
The effect of a life skills education program on mental health and social competencies among young prisoners in Cambodia: an intervention study
Authors: Pat Puthy , Richter-Sundberg Linda , Jegannathan Bhoomikumar , Sebastian Miguel San 
Published: December 2021

Abstract
Background: Young prisoners are more susceptible to mental health problems as compared to adult prisoners and the general population. The lack of life skills has been reported as one of the main reasons for this vulnerability.Method: This study aimed to assess the effectiveness of the life skills education program on mental health and life skills among young prisoners in Cambodia. A pre-post intervention study was conducted with 412 young prisoners aged 15–24 years who were randomised into intervention and control groups. The Youth Self-Report and Life Skills Development – Adolescent Form scales were applied to assess impact of the intervention program.Result: Both intervention and control groups reported decreased mental health problems (DiD=3.78, p=0.34) and improved life skills competencies (DiD=0.39, p=0.80) after the intervention; however, the differences were not statistically significant.Conclusion: Further studies should be conducted to evaluate long-term effects of the like skills education program in the prison setting.
Two-Echelon Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery
Authors: Zhou Hang , Qin Hu , Zhang Zizhen , Li Jiliu 
Published: December 2021

Abstract
In this paper, we propose a tabu search algorithm for the two-echelon vehicle routing problem with time windows and simultaneous pickup and delivery (2E-VRPTWSPD), which is a new variant of the two-echelon vehicle routing problem (2E-VRP) by considering the time windows constraints and simultaneous pickup and delivery. In 2EVRPTWSPD, the pickup and delivery activities are performed simultaneously by the same vehicles through the depot to satellites in the first echelon and satellites to customers in the second echelon, where each customer has a specified time window. To solve this problem, firstly, we formulate the problem with a mathematical model. Then, we implement a variable neighborhood tabu search algorithm with the proposed solution representation of dummy satellites to solve large-scale instances. Dummy satellites time windows are used in our algorithm to speed up the algorithm. Finally, we generate two instance sets based on the existing 2E-VRP and 2E-VRPTW benchmark sets and conduct additional experiments to analyze the performance of our algorithm.
Optimization of Irrigation Water Depth under Water Limiting Condition
Authors: Kamali Mohammad Ismaeil , Ansari Hossein , Nazari Rouzbeh 
Published: December 2021

Abstract
Water productivity is a major challenge in all agricultural regions and despite the use of pressurized irrigation system, it has not increased as expected in Iran. In addition, in spite of water shortage in Iran, gardeners because of lack of knowledge in economic consequences do not welcome deficit irrigation and irrigation scheduling. To this end, optimization of irrigation water depth in an orange orchard was conducted for two irrigation scheduling methods (with and without 4 days irrigation frequency) under water and land limitations conditions by mathematical analysis of production and cost functions. Then, their effect on the net income by changing in water and fruit price was assessed. Production and cost functions were developed based on two scenarios of applied water including only irrigation water depth and irrigation water depth plus rainfall. According to results, when water is limiting, by using the optimum water depth (Ww), 26% of irrigation water use can be saved that causes only 3–4% decrease in the net income per unit of land and 16% increase in the net income per unit of irrigation water. In addition, when water limiting is serious, using 46% deficit irrigation (Wew) is more useful and resultes the highest water productivity, even though it causes 14–17% decrease in the net income per unit of land. However in water limiting condition, if land is not limiting, using Wew causes the maximum net income per unit of land even 50–60% more than full irrigation. Moreover, using the optimum water depths in water limitation conditions (Ww and Wew) increases the water productivity 26–47% relative to full irrigation. On the other side, the net income and the amount of optimum water depths are not sensitive to the price of water at the present value of water. However, they are highly sensitive to the price of fruit. Furthermore, having an irrigation schedule causes 27% increase in the net income per unit of land. According to positive effects of deficit irrigation and irrigation scheduling on the water productivity and the income, they are highly recommended for addressing water scarcity in Iran.