bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of orthodontic bone stretching for correcting malpositioned dental implants
Authors: Bousquet Philippe , Barthélemi Stéphane , Artz Christèle , Delsol Laurent 
Published: October 2021

AbstractBackgroundDental implants are sometimes initially placed in a wrong position leading to esthetic damage, which is difficult to solve with prosthetics. Moreover, implants placed in the anterior sector, like ankylosed teeth, are frequently found in a wrong position over time with infraocclusion because of continuous anterior alveolar growth. Different treatments have been proposed to manage the consequences of malpositioned dental implants.Case presentationThis paper describes a surgical and orthodontic new procedure that can be used to relocate an implant in a wrong position: the Orthodontic Bone Stretching technique (OBS), which involves deep partial osteotomies combined with heavy orthodontic forces. The applied force facilitates esthetic rehabilitation with a movement towards the occlusal plane and can modify the implant axis and the gingival line alignment. This relocation is made possible thanks to a bone stretching phenomenon in the surgical area without immediate mobilization or repositioning of an alveolar segment. Three cases with the need for implant repositioning are presented here and were treated with the OBS technique.ConclusionIn the three cases presented, implant relocation was successfully performed with the OBS technique and the prosthetic crown was modified to improve esthetic results.
Circ_0045714/miR-331-3p interaction affects IL-1β-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade
Authors: Ding Ran , Zhou Jinsong , Xu Jianguo , Lu Huajie , Zhang Tingting , Xiang Xiong , Shi Zhen 
Published: October 2021

Abstract
Background
Osteoarthritis (OA) is characterized by joint pain and joint function limitation. Hsa_circ_0045714 (circ_0045714) is a novel OA-related circular RNA. However, its repertoire remains to be further clarified in joint chondrocytes.

Methods
RNA and protein expression levels and inflammatory factor levels were detected by real-time quantitative polymerase chain reaction, western blotting and enzyme-linked immunosorbent assay. Cell proliferation and apoptosis were determined by colony formation assay, cell counting kit-8 assay and apoptosis assay. Direct interaction was predicted by bioinformatics method and confirmed by dual-luciferase reporter assay.

Results
Expression of circ_0045714 and phosphoinositide-3-kinase (PI3K) regulatory subunit 3 (PIK3R3) was declined, and microRNA (miR)-331-3p was promoted in knee articular cartilages and cells from OA patients, as well as interleukin (IL)-1β-challenged human articular chondrocytes (HAC) cell line. In stimulation of IL-1β, HAC cells showed a loss of colony formation ability, cell viability and expression of Bcl-2 and Collagen II, allied with an increase in apoptosis rate and levels of IL-6, IL-8 and tumor necrosis factor-α, Bcl-2-associated X protein, cleaved caspase-3, and ADAM with thrombospondin motif-5. Noticeably, overexpressing circ_0045714 and inhibiting miR-331-3p could suppress IL-1β-evoked these effects, and both were through up-regulating PIK3R3, a key gene in PI3K/AKT signaling pathway. Mechanically, circ_0045714 functioned as competing endogenous RNA (ceRNA) for miR-331-3p and further regulated expression of the downstream target gene PIK3R3.

Conclusion
There was a novel circ_0045714/miR-331-3p/PIK3R3 ceRNA axis in HAC, and its inhibition might be one mechanism of HAC injury in OA.
Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway
Authors: Vatne Nina A. , Stormoen Marit , Lund Morten , Devold Magnus , Rimstad Espen , Wessel Øystein 
Published: October 2021

AbstractPiscine orthoreovirus-1 (PRV-1) is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). However, it has been shown that PRV-1 variants differ in their ability to induce HSMI. The objective of this work was to identify the PRV-1 variants in Norwegian aquaculture and their geographical distribution. Sequencing and subsequent analysis of the five genomic segments (S1, S4, M2, L1 and L2) putatively linked to virulence, made out the basis of the study. Thirty-seven Norwegian PRV-1 isolates were sequenced, and they grouped into eight genogroups based on combinations of the five analyzed genomic segments. Two groups were defined as high-virulent and two low-virulent, based on comparison with PRV-1 reference isolates with known virulence. The remaining four groups were of unknown virulence. The geographic distribution indicated a higher frequency of the high-virulent isolates in the mid- and northern regions. The present study confirms circulation of both high- and low-virulent isolates of PRV-1 in farmed Atlantic salmon in Norway. To reduce the impact of PRV-1 related disease, detection and differentiation between high- and low-virulent genogroups of PRV-1 could be a targeted approach for reduction of high-virulent variants.
Certain fractional formulas of the extended k-hypergeometric functions
Authors: Abdalla Mohamed , Boulaaras Salah , Akel Mohamed , Idris Sahar Ahmed , Jain Shilpi 
Published: October 2021

AbstractIn this article, we aim to investigate various formulae for the $(p,k)$
(
p
,
k
)
-analogues of Gauss hypergeometric functions, including the integral transforms and the operators of fractional calculus. All the outcomes presented here are of general attractiveness and can yield a number of previous works as special cases.
Determinants of uptake of intermittent preventive treatment for malaria with sulfadoxine pyrimethamine in pregnancy: a cross-sectional analytical study in the Sekondi-Takoradi Metropolis of Ghana
Authors: Anto Francis , Ayepah Christabel , Awini Elizabeth , Bimi Langbong 
Published: October 2021

Abstract
Background
Ghana malaria control programme recommends the uptake of five doses of sulfadoxine pyrimethamine (SP) during pregnancy following the review of the World Health Organization recommendations in 2012. The uptake of higher doses of SP since the implementation of the new policy in 2016, has been low across the country. The current study determined factors that can be improved to increase uptake of SP for intermittent preventive treatment of malaria in pregnancy (IPTp-SP).

Methods
A cross-sectional analytical study was carried out among women who had just delivered in selected health facilities in the Sekondi-Takoradi Metropolis of Ghana. Participants were enrolled from the lying-in wards of the study facilities after delivery. Data including time of initiating antenatal care (ANC), number of visits, time of first dose of SP and number of doses were collected. ANC books were also reviewed. Logistic and ordered logistic regression analysis were done to determine respondent factors associated with uptake of IPTp-SP using Stata 15.

Results
Out of the 496 mothers who participated in the study, 370 (74.60%) initiated ANC during the first trimester, 123 (24.80%) during the second, with only three (0.60%) starting during the third trimester. Majority (463/496, 93.35%) made > 4 visits. Uptake of at least one dose of SP was 98.79% (490/496), ≥ 2 doses was 92.75 (460/496), ≥ 3 doses was 80.65% (400/496) and ≥ 4 doses was 40.32% (200/496). Uptake of IPTp 5 was very low (6.65%, 33/490).
A unit increase of one ANC visit was associated with 20% higher odds of receiving 3-4 doses of SP with respect to receiving 1-2 doses (p <  0.001). The probability of receiving 5 or more doses of SP with respect to 1-2 doses was 26% higher with a unit increase of one ANC visit.

Conclusion
Uptake of 3-4 doses and ≥ 5 doses of SP were associated with making more ANC visits. Encouraging and motivating expectant mothers to make more ANC visits can improve uptake of ≥5 doses of SP.
Predictors of physical activity among women in Bojnourd, north east of Iran: Pender’s health promotion model
Authors: Tavakoly Sany Seyedeh Belin , Vahedian Shahroodi Mohammad , Hosseini Khaboshan Zahra , Orooji Arezoo , Esmaeily Habibollah , Jafari Alireza , Tajfard Mohammad 
Published: October 2021

AbstractBackgroundThis study examined how socio-demographic characteristics constructs derived from the health promotion model (HPM) influence the level of physical activity (PA) women in Bojnourd, North East of Iran.MethodThis cross-sectional study has been carried out through multi-stage sampling design on 356 women aged 18–60 years living in Iran. Data was collected through reliable and valid questionnaire survey women who were selected from their homes.ResultsMost of participants (53.40%) had a low level of physical activity behaviors with minimal physical activity (PA) scores. Using regression analysis showed that 23.22% of the total variance in PA behaviors was predicted by socio-demographic variables, whilst 40.81% of the variance in PA behaviors was predicted by constructs from the HPM. The results from Path modeling indicated that prior behavior, interpersonal influences, perceived self-efficacy, perceived barriers and commitment to PA, were significant predictors for PA behaviors with 86.93% of total effects on PA, whereas, activity-related affect and situational influences had no significant effect on the PA behaviors.ConclusionsWe found that constructs derived from the HPM are determinants of PA among Iranian women and may be important in developing educational intervention programs to facilitate a physically active lifestyle in this population.
Tuberculous pleural effusion in a patient with sympathetic ophthalmia on immunosuppression: a case report
Authors: Thiagarajan Dharshana , Teh Daphne Ai Lin , Ahmad Tarmidzi Nor Azita , Ishak Hamisah , Abu Bakar Zamzurina , Bastion Mae-Lynn Catherine 
Published: October 2021

Abstract
Background
Tuberculous pleural effusion (TPE) is paucibacillary, making its diagnosis difficult based on laboratory investigations alone. We present a case of a patient with a TPE who was initially misdiagnosed to have azathioprine-induced lung injury. The diagnosis of TPE was arrived at with the help of clinical assessment, laboratory and radiological investigations.

Case presentation
A 25-year-old chronic smoker with sympathetic ophthalmia on long-term immunosuppression, latent tuberculosis infection and a significant family history of tuberculosis presented with a three-week history of productive cough, low-grade fever, night sweats and weight loss. Examination of the lungs showed reduced breath sounds at the right lower zone. Chest x-ray showed minimal right pleural effusion with a small area of right upper lobe consolidation. The pleural fluid was exudative with predominant mononuclear leukocytes. Direct smears of sputum and pleural fluid; polymerase chain reaction of pleural fluid; and sputum, pleural fluid and blood cultures were negative for M. tuberculosis (MTB) and other organisms. As he did not respond to a course of broad-spectrum antibiotics, he was then treated as a case of azathioprine-induced lung injury. However, his condition did not improve despite the cessation of azathioprine. A contrast-enhanced computed tomography of the thorax showed right upper lobe consolidation with tree-in-bud changes, bilateral lung atelectasis, subpleural nodule, mild right pleural effusion and mediastinal lymphadenopathy. Bronchoalveolar lavage was negative for malignant cells and microorganisms including, MTB. However, no pleural biopsy was done. He was empirically treated with anti-tubercular therapy for 9 months duration and showed complete recovery.

Conclusion
A high index of suspicion for TPE is required in individuals with immunosuppression living in regions endemic to tuberculosis. Targeted investigations and sound clinical judgement allow early diagnosis and prompt treatment initiation to prevent morbidity and mortality.
A place migrants would call home: open-ended constructions and social determinants over time among Ecuadorians in three European cities
Authors: Boccagni Paolo , Armanni Bernardo , Santinello Cristiano 
Published: October 2021

AbstractIs there a place in particular that international migrants would call home? How do they talk about it, where does it lie, and what characteristics is it expected to have, given their demographics and patterns of settlement? Similar questions are meaningful in themselves and in illuminating migrant biographical, family and housing trajectories. We address them, in this paper, through the categorization and multinomial analysis of the responses to a dedicated open-ended question in a survey on Ecuadorians in Madrid, Milan and London (n = 1175). This original dataset allows us to explore migrant views of home against the background of their demographics and of their migration and housing conditions. We analyse respondents’ ways to articulate, spatialize and prioritize key aspects of home through a logit model, thereby assessing their association with age, length of stay, housing tenure, family networks and city of residence. Overall, their predominant construction of home points to a place in the country of settlement, but not necessarily to their own dwelling. Younger and newcomer immigrants see home as a primarily relational construct, whereas older and long-stayers emphasize its place-based and private dimension. Significant variations in the expected emplacement and bases of home can be found across cities of residence. However, no significant variations are associated either with gender or with migrants’ transnational engagement.
Development and Proof of Concept of an Audit Toolkit for the Safe Handling of Cytotoxic Drugs in Low- and Middle-Income Countries
Authors: von Grünigen Sandrine , Falaschi Ludivine , Guichard Nicolas , Fleury-Souverain Sandrine , Geissbühler Antoine , Bonnabry Pascal 
Published: October 2021

PURPOSE Chemotherapies are considered high-risk drugs for patient and staff safety. Considering the rising burden of cancer and the increasing use of chemotherapy drugs in low- and middle-income countries (LMICs), promoting continuous improvements in the safety and quality of practices in these settings is essential. This paper describes the development and proof of concept of a toolkit to audit chemotherapy handling practices in the health care facilities of LMICs. METHODS A steering committee defined the audit method and the toolkit content. Several checklists were developed to facilitate the audit and data collection. Items included in checklists were derived from key reference works on safe handling. Different tools were validated using Delphi surveys and expert reviews. Audits of pilot sites were performed to test the toolkit's applicability and relevance. RESULTS The toolkit contains a 134-item global assessment tool for the different processes at each step of the medication pathway and three step-specific observation checklists to assess different health workers' practices during the prescription, preparation, and administration of chemotherapies. The toolkit also proposes using a surface-wipe sampling method to measure any cytotoxic contamination of the immediate environment. The toolkit was tested in three teaching hospitals in Africa. CONCLUSION The toolkit developed was successfully implemented in a variety of LMIC settings, providing a comprehensive evaluation of the quality and safety of the chemotherapy drug handling practices in participating health care facilities. This toolkit can help facilities in LMICs to implement a new approach to continuously improving the quality and safety of their practices and ultimately ensure patient and staff safety.
Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Transarterial Chemoembolization for Large Hepatocellular Carcinoma: A Randomized Phase III Trial
Authors: Li Qi-Jiong , He Min-Ke , Chen Huan-Wei , Fang Wan-Qiang , Zhou Yuan-Min , Xu Li , Wei Wei , Zhang Yao-Jun , Guo Ying , Guo Rong-Ping , Chen Min-Shan , Shi Ming 
Published: October 2021

PURPOSE In a previous phase II trial, hepatic arterial infusion chemotherapy (HAIC) with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX) yielded higher treatment responses than transarterial chemoembolization (TACE) in large unresectable hepatocellular carcinoma. We aimed to compare the overall survival of patients treated with FOLFOX-HAIC versus TACE as first-line treatment in this population. METHODS In this randomized, multicenter, open-label trial, adults with unresectable hepatocellular carcinoma (largest diameter ≥ 7 cm) without macrovascular invasion or extrahepatic spread were randomly assigned 1:1 to FOLFOX-HAIC (oxaliplatin 130 mg/m2, leucovorin 400 mg/m2, fluorouracil bolus 400 mg/m2 on day 1, and fluorouracil infusion 2,400 mg/m2 for 24 hours, once every 3 weeks) or TACE (epirubicin 50 mg, lobaplatin 50 mg, and lipiodol and polyvinyl alcohol particles). The primary end point was overall survival by intention-to-treat analysis. Safety was assessed in patients who received ≥ 1 cycle of study treatment. RESULTS Between October 1, 2016, and November 23, 2018, 315 patients were randomly assigned to FOLFOX-HAIC (n = 159) or TACE (n = 156). The median overall survival in the FOLFOX-HAIC group was 23.1 months (95% CI, 18.5 to 27.7) versus 16.1 months (95% CI, 14.3 to 17.9) in the TACE group (hazard ratio, 0.58; 95% CI, 0.45 to 0.75; P < .001). The FOLFOX-HAIC group showed a higher response rate than the TACE group (73 [46%] v 28 [18%]; P < .001) and a longer median progression-free survival (9.6 [95% CI, 7.4 to 11.9] v 5.4 months [95% CI, 3.8 to 7.0], P < .001). The incidence of serious adverse events was higher in the TACE group than in the FOLFOX-HAIC group (30% v 19%, P = .03). Two deaths in the FOLFOX-HAIC group and two in the TACE group were deemed to be treatment-related. CONCLUSION FOLFOX-HAIC significantly improved overall survival over TACE in patients with unresectable large hepatocellular carcinoma.
Kinematics of sea star legged locomotion
Authors: Ellers Olaf , Khoriaty Melody , Johnson Amy S. 
Published: October 2021

ABSTRACT
Sea stars have slower crawling and faster bouncing gaits. Both speed and oscillation amplitude increase during the transition from crawling to oscillating. In the bouncy gait, oscillating vertical velocities precede oscillating horizontal velocities by 90 deg, as reflected by clockwise circular hodographs. Potential energy precedes horizontal kinetic energy by 9.6 deg and so they are nearly in phase. These phase relationships resemble terrestrial running gaits, except that podia are always on the ground. Kinetic and potential energy scale with body mass as Mb   1.1, with the change in kinetic energy consistently two orders of magnitude less, indicating that efficient exchange is not feasible. Frequency of the bouncy gait scales with Mb−0.14, which is similar to continuously running vertebrates and indicates that gravitational forces are important. This scaling differs from the Hill model, in which scaling of muscle forces determine frequency. We propose a simple torque-stabilized inverted pendulum (TS-IP) model to conceptualize the dynamics of this gait. The TS-IP model incorporates mathematics equivalent to an angular spring, but implemented by a nearly constant upward force generated by the podia in each step. That upward force is just larger than the force required to sustain the underwater weight of the sea star. Even though the bouncy gait is the rapid gait for these sea stars, the pace of movement is still very slow. In fact, the observed Froude numbers (10−2 to 10−3) are much lower than those typical of vertebrate locomotion and are as low or lower than those reported for slow-walking fruit flies, which are the lowest values for pedestrian Froude numbers of which we are aware.
Diet mediates thermal performance traits: implications for marine ectotherms
Authors: Hardison Emily A. , Kraskura Krista , Van Wert Jacey , Nguyen Tina , Eliason Erika J. 
Published: October 2021

ABSTRACT
Thermal acclimation is a key process enabling ectotherms to cope with temperature change. To undergo a successful acclimation response, ectotherms require energy and nutritional building blocks obtained from their diet. However, diet is often overlooked as a factor that can alter acclimation responses. Using a temperate omnivorous fish, opaleye (Girella nigricans), as a model system, we tested the hypotheses that (1) diet can impact the magnitude of thermal acclimation responses and (2) traits vary in their sensitivity to both temperature acclimation and diet. We fed opaleye a simple omnivorous diet (ad libitum Artemia sp. and Ulva sp.) or a carnivorous diet (ad libitum Artemia sp.) at two ecologically relevant temperatures (12 and 20°C) and measured a suite of whole-animal (growth, sprint speed, metabolism), organ (cardiac thermal tolerance) and cellular-level traits (oxidative stress, glycolytic capacity). When opaleye were offered two diet options compared with one, they had reduced cardiovascular thermal performance and higher standard metabolic rate under conditions representative of the maximal seasonal temperature the population experiences (20°C). Further, sprint speed and absolute aerobic scope were insensitive to diet and temperature, while growth was highly sensitive to temperature but not diet, and standard metabolic rate and maximum heart rate were sensitive to both diet and temperature. Our results reveal that diet influences thermal performance in trait-specific ways, which could create diet trade-offs for generalist ectotherms living in thermally variable environments. Ectotherms that alter their diet may be able to regulate their performance at different environmental temperatures.
SRAP analysis of brown planthopper (Nilaparvata lugens) populations maintained on differential rice host varieties
Authors: Chaerani Chaerani , Dadang Ahmad , Fatimah Fatimah , Amir Husin Bahagiawati , Sutrisno Sutrisno , Yunus Muhamad 
Published: October 2021

Abstract. Chaerani, Dadang A, Fatimah, Husin BA, Sutrisno, Yunus M. 2021. SRAP analysis of brown planthopper (Nilaparvata lugens) populations maintained on differential rice host varieties. Biodiversitas 22: 4266-4272. Brown planthopper (Nilaparvata lugens Stål) biotypes differ in virulence to rice varieties carrying different Bph resistance genes. These biotypes are reported can be genetically discriminated against using DNA markers. Four brown planthoppers (BPH) populations, which displayed two virulence phenotypes, have been produced by selection and adaptation on four differential host varieties. Sequence-related amplified polymorphism (SRAP) marker preferentially amplifies the coding regions in the genome and, thus, can discriminate the observed virulence variations among those populations. This study aimed to analyze the genetic variation of four developed BPH populations using SRAP markers. Genetic analysis of a total of 40 BPH females with 18 polymorphic primers revealed equal genetic diversity parameter values among populations (Na: 1.1 to 1.4, Ne: 1.2 to 1.3, I: 0.22 to 0.29, He: 0.14 to 0.18, and UHe: 0.15 to 0.19). Analysis of population structure by AMOVA indicated low genetic variation among populations (9%). Still, pairwise PhiPT population values between all pairs of the population revealed the presence of moderate genetic differentiations (PhiPT ranged from 0.57 to 0.133, P<0.01). Two partial clusters in plots of PCoA were corresponded to two virulence groups, indicating the ability of SRAP markers to discriminate virulence phenotype. Further selection and adaptation are expected can form four desired virulence patterns with complete genetic separation among the population before its application as resistance screening agents of rice lines.