bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atraumatic Technique for Removal of Lingually Placed Mandibular Teeth
Authors: Karikal Arvind , Shetty Tripthi P. , S. Gopinath Thilak P. , Kudthadka Arathi 
Published: January 2021

AbstractWe describe an innovative and easy method to remove lingually placed mandibular single-rooted teeth which are not accessible to regular forceps method of extraction. This method is simple and atraumatic and preserves the lingual alveolar plate which is important for implant placement and socket perseveration. This note is aimed at highlighting a simple atraumatic technique for removal of these types of single-rooted teeth erupting on the lingual side with the help of surgical screws. This technique is more economical and considerably less cumbersome than the existing Benex system.
Comparative Analysis of Radiofrequency Ablation and Microwave Ablation for Critically Located Hepatocellular Carcinomas Smaller than 5 cm
Authors: Ramalingam Ravindran , Mukund Amar , Anandpara Karan Manoj , Patidar Yashwant , Sarin Shiv Kumar 
Published: January 2021

AbstractPurpose To compare the safety and efficacy of radiofrequency ablation (RFA) versus microwave ablation (MWA) for hepatocellular carcinomas (HCC) smaller than 5 cm in critical locations.Methods Single-center retrospective study of all patients who underwent RFA/MWA for HCC from July 2015 to Dec 2019. Critical location includes exophytic tumors, tumors ≤ 5 mm from the diaphragm, heart, gallbladder, kidney, gastrointestinal tract, and ≤ 10 mm from large vessels with caliber of ≥ 3 mm. Treatment effectiveness, local tumor progression, and complication rates were evaluated.Results Out of 119 patients with 147 HCC nodules in critical location, 65 (M:F = 49:16; mean age–61.7) were included in RFA group and 54 (M:F =43:11; mean age–60.5) in MWA group. Mean follow-up period was 16.5 and 14.8 months, respectively. At first follow-up imaging, 66/78 tumors in RFA group and 57/69 tumors in MWA group showed complete ablation with primary treatment effectiveness rates of 84.6% and 82.6%, respectively (p = 0.741). Local tumor progression (LTP) rate was 21.8% (17/78) and 20.3% (14/69), respectively (p = 0.826). Median time to LTP was 12 and 13.5 months, respectively. Fourteen tumors in RFA group and 12 in MWA group underwent reablation with a secondary treatment effectiveness rates of 78.6% (14/17) and 83.3% (12/14), respectively (p = 0.757). Mean LTP-free survival was 37.2 and 28.1 months, respectively. The total complication rate was 36.9% and 31.5%, respectively (p = 0.535) with no major complications in both the groups.Conclusion Our data suggest that both MWA and RFA are equally safe and effective for treating HCCs < 5 cm in critical locations.
The Promise of Percutaneous Transhepatic Variceal Embolization for Both Gastroesophageal and Ectopic Varices—An Australian Case Series
Authors: Ambati Chaitanya , Danta Mark , Boshell David , Ende Jesse , Williams David , Chaganti Joga 
Published: January 2021

Abstract
Purpose This article aims to report Australian experience of percutaneous transhepatic embolization of gastroesophageal and ectopic varices.
Method Eight consecutive patients (mean age 61.8 years, 7 men) who had undergone percutaneous transhepatic variceal embolization (PTVE) for variceal bleeding between October 2013 and February 2020 were analyzed. All patients were admitted from the emergency department. The following embolic materials were used—coils, Onyx 18 (Medtronic), and n-butyl cyanoacrylate plus lipiodol.
Results Post-PTVE, all eight patients demonstrated clinical and radiological improvement in the immediate postprocedure period (< 24 hours). Patients were followed for a mean of 44 ± 24 days postprocedure. Two patients were lost to follow-up. The postprocedure complications included rebleeding (n = 1), hepatic encephalopathy (n = 1), hemoperitoneum (n = 1), ileus (n = 1), and abdominal pain (n = 3).
Conclusion PTVE is an effective treatment option for patients with uncontrolled variceal bleeding (ectopic as well as gastroesophageal) especially when the traditional therapies such as transjugular intrahepatic portosystemic shunts, endoscopic variceal ligation, and balloon-occluded retrograde transvenous obliteration are contraindicated or ineffective.
Analysis System for Emotional Behavior in Football (ASEB-F): matches of FC Red Bull Salzburg without supporters during the COVID-19 pandemic
Authors: Leitner Michael Christian , Richlan Fabio 
Published: January 2021

AbstractDuring the COVID-19 pandemic the “Austrian Bundesliga”—as in many other European football leagues—resumed the season around the end of May 2020 without supporters in the stadiums. These so-called “ghost games” represent a unique and unprecedented opportunity to study the effects of the (missing) audience on the behavior and experience of sports professionals. The present study is the first of its kind, aimed at addressing the psychological effects of these “ghost games” on football players, staff, and officials. The newly developed “Analysis System for Emotional Behavior in Football” (ASEB-F) was used to video analyze and compare the behavior of players, staff, and officials in—in sum—20 games of FC Red Bull Salzburg in the “Championship Groups” of season 2018/19 (“regular games”) and season 2019/20 (“ghost games”). Additionally, the two seasons were compared based on official matchday statistics. Overall, there were 19.5% fewer emotional situations in “ghost games” than in “regular games”. The results further show a relative increase in the number of emotional behaviors “Self-Adaptor” (+0.8%), “Protest” (+4.2%), and “Fair-Play-Behavior” (+3.1%) in “ghost games”, whereas “Words fight” (−5.1%) and “Discussion” (−5.1%) decreased in “ghost games”. In “regular games” referees were actively involved in 39.4% of all documented emotional situations, whereas in “ghost games” referees were actively involved in only 25.2% of all documented emotional situations (−14.2%). Chronological analysis within games—from kick-on to kick-off—further shows substantial differences in the temporal occurrence of emotional behavior between “regular games” and “ghost games”. The study provides unprecedented insights into the effects of missing supporters in the football games during the COVID-19 pandemic on emotional behavior on the pitch. Without the external factor of supporters, players and staff acted more factually and got less carried away with longer-lasting and extensive “Words fights” and “Discussion”. The evidence from this study indicates that—from a sport psychological perspective—the absence of supporters has a substantial influence on the experience and behavior of players, staff, and officials alike.
Superconductivity in Mo5GeB2 with a tetragonal structure
Authors: Xu Binjie , Lou Zhefeng , Chen Huancheng , Zhou Yuxing , Chen Qin , Chen Shuijin , Wu Chunxiang , Wang Hangdong , Yang Jinhu , Du Jianhua , Fang Minghu 
Published: January 2021

Abstract
The discovery of 39 K superconductivity in MgB2 and the recent observations of high-T

c
superconductivity in the high-pressured hydrides motivate ones to search for new superconductors in the compounds containing H or B light element. In this article, we chose the heavier Ge to replace the Si in the ternary borides Mo5SiB2 with the Cr5B3 type tetragonal structure, a relative new group borosilicate superconductors, and prepared Mo5GeB2 polycrystalline sample. By the combination of resistivity, magnetization, and specific heat measurements and band calculations, we determine its superconducting parameters. It was found that Mo5GeB2 is a type II superconductor, with the critical temperature T

c
= 5.4 K, and the Ginzburg–Landau (GL) parameter k

GL
(0) = 4.2. The estimated electron-phonon coupling constant λ

ph
(0.57) and the specific heat jump

△

C

e
l

/

γ
n

T
c

(1.33) demonstrate that Mo5GeB2 is a weak-coupling, single-gap phonon-mediated superconductor. Band calculations reveal that Mo5GeB2 has a similar density of state (DOS) near Fermi energy to that of Mo5SiB2 with the same T

c
, but smaller than that Mo5PB2 with T

c
= 9.2 K.
Influence of kinetic energy on the metrology of Rabi frequency
Authors: Zhang Xingyu , Wang Xiaoguang 
Published: January 2021

Abstract
The interacting model describing the Rabi transition is essential in studying atom-photon interactions, where the kinetic energy term is often neglected for the convenience of analysis. We first study the approximation through the fidelity approach and verify its valid region in the parameter space of detuning and momentum. We find that as the radiation field’s momentum and the absolute value of detuning decrease, the approximation becomes valid. We further discover that the omission of the kinetic energy term will overestimate the measuring accuracy of the Rabi frequency in some parameter regions and underestimate the precision in other regimes with Fisher information tools’ help. Notably, a specific choice of the initial Gaussian state’s variance in position space will improve the measuring accuracy when we take the kinetic energy term into account. We also study the realistic measurement of the Rabi frequency for cases with and without the kinetic energy.
Excited-state quantum phase transitions
Authors: Cejnar Pavel , Stránský Pavel , Macek Michal , Kloc Michal 
Published: January 2021

Abstract
We review the effects of excited-state quantum phase transitions (ESQPTs) in interacting many-body systems with finite numbers of collective degrees of freedom. We classify typical ESQPT signatures in the spectra of energy eigenstates with respect to the underlying classical dynamics and outline a variety of quantum systems in which they occur. We describe thermodynamic and dynamic consequences of ESQPTs, like those in microcanonical thermodynamics, quantum quench dynamics, and in the response to nearly adiabatic or periodic driving. We hint at some generalizations of the ESQPT concept in periodic lattices and in resonant tunneling systems.
A discussion on the possible involvement of singlet oxygen in oxygen electrocatalysis
Authors: Chen Gao , Sun Yuanmiao , Chen Riccardo Ruixi , Biz Chiara , Fisher Adrian C , Sherburne Matthew P , Ager III Joel W , Gracia Jose , Xu Zhichuan J 
Published: January 2021

Abstract
The dioxygen molecule has two bound states, singlet and triplet, which are different in energy, lifetime, and reactivity. In the context of oxygen electrocatalysis as applied to fuel cells and water splitting the involved O2 is typically considered to be exclusively in its triplet ground state. However, applying spin-conservation rules for the transformation between triplet O2 and singlet OH−/H2O reaction intermediates predicts an additional free energy barrier associated with the required spin flip. As a result, for conditions under which both can form, the formation of triplet dioxygen from the singlet OH−/H2O might be slower than the formation of singlet O2. Correspondingly, singlet O2 might be more active than triplet O2 in the oxygen reduction reaction. Here, we discuss the possible existence and influence of singlet oxygen in oxygen electrocatalysis. Some perspectives for studying singlet oxygen in oxygen electrocatalysis are also provided.
Enzyme promiscuity prediction using hierarchy-informed multi-label classification
Authors: Visani Gian Marco , Hughes Michael C , Hassoun Soha 
Published: January 2021

Abstract

Motivation
As experimental efforts are costly and time consuming, computational characterization of enzyme capabilities is an attractive alternative. We present and evaluate several machine-learning models to predict which of 983 distinct enzymes, as defined via the Enzyme Commission (EC) numbers, are likely to interact with a given query molecule. Our data consists of enzyme-substrate interactions from the BRENDA database. Some interactions are attributed to natural selection and involve the enzyme’s natural substrates. The majority of the interactions however involve non-natural substrates, thus reflecting promiscuous enzymatic activities.

Results
We frame this ‘enzyme promiscuity prediction’ problem as a multi-label classification task. We maximally utilize inhibitor and unlabeled data to train prediction models that can take advantage of known hierarchical relationships between enzyme classes. We report that a hierarchical multi-label neural network, EPP-HMCNF, is the best model for solving this problem, outperforming k-nearest neighbors similarity-based and other machine-learning models. We show that inhibitor information during training consistently improves predictive power, particularly for EPP-HMCNF. We also show that all promiscuity prediction models perform worse under a realistic data split when compared to a random data split, and when evaluating performance on non-natural substrates compared to natural substrates.

Availability and implementation
We provide Python code and data for EPP-HMCNF and other models in a repository termed EPP (Enzyme Promiscuity Prediction) at https://github.com/hassounlab/EPP.

Supplementary information
Supplementary data are available at Bioinformatics online.
Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome
Authors: Banerji Rajeswari , Huynh Christopher , Figueroa Francisco , Dinday Matthew T , Baraban Scott C , Patel Manisha 
Published: January 2021

AbstractEnergy-producing pathways are novel therapeutic targets for the treatment of neurodevelopmental disorders. Here, we focussed on correcting metabolic defects in a catastrophic paediatric epilepsy, Dravet syndrome which is caused by mutations in sodium channel NaV1.1 gene, SCN1A. We utilized a translatable zebrafish model of Dravet syndrome (scn1lab) which exhibits key characteristics of patients with Dravet syndrome and shows metabolic deficits accompanied by down-regulation of gluconeogenesis genes, pck1 and pck2. Using a metabolism-based small library screen, we identified compounds that increased gluconeogenesis via up-regulation of pck1 gene expression in scn1lab larvae. Treatment with PK11195, a pck1 activator and a translocator protein ligand, normalized dys-regulated glucose levels, metabolic deficits, translocator protein expression and significantly decreased electrographic seizures in mutant larvae. Inhibition of pck1 in wild-type larvae mimicked metabolic and behaviour defects observed in scn1lab mutants. Together, this suggests that correcting dys-regulated metabolic pathways can be therapeutic in neurodevelopmental disorders such as Dravet syndrome arising from ion channel dysfunction.
Sex differences in cardiorespiratory fitness are explained by blood volume and oxygen carrying capacity
Authors: Diaz-Canestro Candela , Pentz Brandon , Sehgal Arshia , Montero David 
Published: January 2021

AbstractAims Intrinsic sex differences in fundamental blood attributes have long been hypothesized to contribute to the gap in cardiorespiratory fitness between men and women. This study experimentally assessed the role of blood volume and oxygen (O2) carrying capacity on sex differences in cardiac function and aerobic power.Methods and results Healthy women and men (n = 60) throughout the mature adult lifespan (42–88 yr) were matched by age and physical activity levels. Transthoracic echocardiography, central blood pressure, and O2 uptake were assessed throughout incremental exercise (cycle ergometry). Main outcomes such as left ventricular end-diastolic volume (LVEDV), stroke volume (SV), cardiac output (Q), and peak O2 uptake (VO2peak), as well as blood volume (BV) were determined with established methods. Measurements were repeated in men following blood withdrawal and O2 carrying capacity reduction matching women’s levels. Prior to blood normalization, BV and O2 carrying capacity were markedly reduced in women compared with men (P &lt; 0.001). Blood normalization resulted in a precise match of BV (82.36 ± 9.83 vs. 82.34 ± 7.70 ml·kg−1, P = 0.993) and O2 carrying capacity (12.0 ± 0.6 vs. 12.0 ± 0.7 g·dl−1, P = 0.562) between women and men. Body size-adjusted cardiac filling and output (LVEDV, SV, Q) during exercise as well as VO2peak (30.8 ± 7.5 vs. 35.6 ± 8.7 ml·min−1·kg−1, P &lt; 0.001) were lower in women compared with men prior to blood normalization. VO2peak did not differ between women and men after blood normalization (30.8 ± 7.5 vs. 29.7 ± 7.4 ml·min−1·kg−1, P = 0.551).Conclusions Sex differences in cardiorespiratory fitness are abolished when blood attributes determining O2 delivery are experimentally matched between adult women and men.
Rapid Spread of Mutant Alleles in Worldwide SARS-CoV-2 Strains Revealed by Genome-Wide Single Nucleotide Polymorphism and Variation Analysis
Authors: Zhu Zhenglin , Liu Gexin , Meng Kaiwen , Yang Liuqing , Liu Di , Meng Geng 
Published: January 2021

Abstract
The novel coronavirus (SARS-CoV-2) has become a pandemic and is threatening human health globally. Here, we report nine newly evolved SARS-CoV-2 single nucleotide polymorphism (SNP) alleles those underwent a rapid increase (seven cases) or decrease (two cases) in their frequency for 30–80% in the initial four months, which are further confirmed by intrahost single nucleotide variation analysis using raw sequence data including 8,217 samples. The nine SNPs are mostly (8/9) located in the coding region and are mainly (6/9) nonsynonymous substitutions. The nine SNPs show a complete linkage in SNP pairs and belong to three different linkage groups, named LG_1 to LG_3. Analyses in population genetics show signatures of adaptive selection toward the mutants in LG_1, but no signal of selection for LG_2. Population genetic analysis results on LG_3 show geological differentiation. Analyses on geographic COVID-19 cases and published clinical data provide evidence that the mutants in LG_1 and LG_3 benefit virus replication and those in LG_1 have a positive correlation with the disease severity in COVID-19-infected patients. The mutants in LG_2 show a bias toward mildness of the disease based on available public clinical data. Our findings may be instructive for epidemiological surveys and disease control of COVID-19 in the future.
Discharge curve-based formation of retired power batteries for secondary use
Authors: Xiao Ziyu , Wu Siqi 
Published: January 2021

Abstract
To address the problem of optional group formation in the process of retired power batteries for secondary use, a detection method based on the ampere-time integration method is used for batch testing of retired power batteries. The dynamic time-bending dynamic time warping distance between different batteries is calculated by comparing the discharge curves during the testing process. Combining the remaining capacity, open circuit voltage and internal resistance of the battery as a common battery classification condition, each condition is normalised and a density canopy + K-means clustering algorithm is applied to regroup the retired power batteries. This method improves the regrouping technique for the retired batteries and improves the performance of the regrouped battery modules in terms of capacity and consistency.
The numerical unified transform method for initial-boundary value problems on the half-line
Authors: Deconinck Bernard , Trogdon Thomas , Yang Xin 
Published: January 2021

Abstract
We implement the unified transform method of Fokas as a numerical method to solve linear evolution partial differential equations on the half-line. The method computes the solution at any $x$ and $t$ without spatial discretization or time stepping. With the help of contour deformations and oscillatory integration techniques, the method’s complexity does not increase for large $x,t$ and the method is more accurate as $x,t$ increase (absolute errors are smaller, relative errors are bounded). Our goal is to make no assumptions on the functional form of the initial or boundary functions beyond some decay and smoothness, while maintaining high accuracy in a large region of the $(x,t)$ plane.
The state of the art in soybean transcriptomics resources and gene coexpression networks
Authors: Almeida-Silva Fabricio , Moharana Kanhu C , Venancio Thiago M 
Published: January 2021

Abstract
In the past decade, over 3000 samples of soybean transcriptomic data have accumulated in public repositories. Here, we review the state of the art in soybean transcriptomics, highlighting the major microarray and RNA-seq studies that investigated soybean transcriptional programs in different tissues and conditions. Further, we propose approaches for integrating such big data using gene coexpression network and outline important web resources that may facilitate soybean data acquisition and analysis, contributing to the acceleration of soybean breeding and functional genomics research.
Single-Laboratory Validation to Extend the Scope of AOAC Official MethodSM 2015.06 to Indian Infant, Child, and Adult Nutritional Matrixes
Authors: Girdhar Rajesh , Thompson Joseph J , Yadlapalli Sudhakar , Srivastava Vinod , Mittal Ashutosh Kumar , Arora Vishal 
Published: January 2021

Abstract

Background
AOAC Method 2015.06 is a Final Action Official MethodSM for the determination of 12 elements (Na, Mg, P, K, Ca, Cr, Mn, Fe, Cu, Zn, Se, and Mo) in infant formula and adult nutritional products, based on inductively coupled plasma (ICP)-MS. Currently, its scope does not include certain kinds of formulations used in India. The method would likely be used more in Indian laboratories if its performance were characterized on Indian matrixes.

Objective
In this study we describe a typical single-laboratory validation (SLV) exercise designed to characterize the precision and accuracy of AOAC Method 2015.06 for common Indian nutritional matrixes so that the scope of the method can be extended to include them.

Method
Six matrixes specific to the Indian market were carried through an SLV and the Standard Method Performance Requirements (SMPRs®) previously published for this method were used to evaluate the results.

Results
The method demonstrated typical repeatability (&lt;5% RSD), and intermediate precision (5–8% RSD) on the Indian matrixes, with very few exceptions. Accuracy was demonstrated by overspike recoveries in the range of 90–110% over 3 days for the Indian matrixes, as well as excellent agreement with previously published results for three additional matrixes tested. Some of the new Indian matrixes required alternate sample preparation procedures versus the usual reconstitution prescribed by the SMPRs.

Conclusions
The SLV results showed that AOAC Method 2015.06 can be extended to include these Indian matrices.

Highlights
The two special sample preparation procedures can now be considered validated.