bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of systemic immune inflammation index in patients with urothelial carcinoma: a systematic review and meta-analysis
Authors: Zheng Lei , Wang Zuoping , Li Yunxiang , Ge Si , Zeng Zhiqiang , Gan Lijian , Meng Chunyang , Li Kangsen 
Published: December 2024

ObjectiveThis review assessed the prognostic significance of the systemic immune inflammation index (SII) in patients with urothelial carcinoma.MethodsWe performed a systematic review and cumulative meta-analysis of the primary outcomes according to the PRISMA criteria, and assessed study quality. Seven databases were searched: Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang, and SinoMed, from the creation of each database until October 2024.ResultsThe meta-analysis included 31 studies, including 14,437 patients with urothelial carcinoma. A low SII was significantly associated with better recurrence-free survival (RFS) (HR = 1.37, 95%CI (1.19, 1.56), P &lt; 0.05), cancer-specific survival (CSS) (HR = 1.87, 95%CI (1.50, 2.34), P &lt; 0.05), and overall survival (OS) (HR = 1.42, 95%CI (1.23, 1.64), P &lt; 0.05). In addition, subgroup analysis found that higher SII was associated with poorer prognosis regardless of treatment regimen, tumor type, or SII cutoff, and that high SII was an important prognostic biomarker in the UC population.ConclusionA low SII may be associated with better RFS, CSS, and OS. The SII can be used as a is a potentially noninvasive and promising prognostic indicator for urothelial carcinoma; however, further studies with appropriate designs and larger sample sizes are needed to verify these findings.
Beta-human chorionic gonadotropin, carbohydrate antigen 19-9, cancer antigen 125, and carcinoembryonic antigen as prognostic and predictive biological markers in bladder cancer
Authors: Yuk Hyeong Dong , Han Jang Hee , Jeong Seung-Hwan , Jeong Chang Wook , Kwak Cheol , Ku Ja Hyeon 
Published: December 2024

IntroductionWe evaluated the prognostic potential of the Beta-human chorionic gonadotropin (β-hCG), Carbohydrate Antigen 19-9 (CA19-9), Cancer Antigen 125 (CA125), and Carcinoembryonic Antigen (CEA) tumor markers for bladder cancer.MethodsWe analyzed the records of 369 patients who underwent radical cystectomy for urothelial cancer (UC) between October 2012 until December 2019. Levels of CA19-9, CA125, CEA, and β-hCG before radical cystectomy were measured in all patient samples, and serum biomarker cutoff values were used as normal and elevated values.Results and discussionThe proportion of abnormal β-hCG (P&lt;0.001), CA19-9 (P&lt;0.001), and CA125 (P=0.033) was significantly higher in locally advanced bladder UC than in organ-confined bladder UC. In patients with preoperative β-hCG and CA125 abnormality, there was poor prognosis of recurrence-free survival (RFS)(P=0.003, P=0.042) and overall survival (OS) (P=0.003, P=0.002). Using the Cox multivariate regression analysis, both β-hCG (HR: 3.88, 95% CI: 1.43–10.25) and CA125 (HR: 6.21, 95% CI: 1.34–32.16) were found to be significant independent factors for predicting OS and RFS. In addition, patients with a high number of increased tumor markers showed significantly worse OS ((P&lt;0.001) and RFS (P=0.002) than patients with a low number of increased tumor markers. In conclusion, serum β-hCG and CA125 levels could potentially be used for UC prognosis in patients undergoing radical cystectomy. To assess their usefulness in evaluating long-term recurrence and survival, further treatment responses and large-scale additional studies are needed.
Understanding unit-based nurse leader experiences in a psychoeducational group program: a qualitative study
Authors: Sawyer Amanda T. , Bailey Amanda K. , Harris Stephanie L. 
Published: December 2024

BackgroundA psychoeducational group program for nurse leaders was developed based on the four themes of resilience, insight, self-compassion, and empowerment and involves therapeutic processing with a licensed mental health professional to alleviate burnout symptoms and protect wellbeing. The program was tested in a randomized controlled trial, which included a qualitative component to examine unit-based nurse leaders' perspectives of their job role and their experiences in the psychoeducational group program.MethodsOnline semi-structured interviews with 18 unit-based nurse leaders were conducted after completion of the program. Thematic analysis using the six-step process identified by Braun and Clarke resulted in the establishment of final themes.ResultsThree primary themes emerged from the data analysis: emotional and mental wellbeing, relationships and social support, and professional experiences. There were nine sub-themes, which included temporal exploration of the themes before, during, and after the program as participants experienced transformation and growth. Findings illustrate that unit-based nurse leaders contend with many workplace stressors that impact their mental health. The psychoeducational group program enabled participants to prioritize self-care, contributed to participants feeling empowered to make positive changes in their work and home lives, and fostered a sense of connection and belonging. Participants also expressed a perceived improvement in their ability to be effective leaders.ConclusionsThese qualitative findings can help guide future implementation efforts of wellbeing programs for unit-based nurse leaders.
Clinical characteristics and risk factors for Mycoplasma pneumoniae pneumonia in children
Authors: Zhao Xueqi , Lv Jiajia , Wu Min , Wu Qun 
Published: December 2024

BackgroundMycoplasma pneumoniae (M. pneumoniae) is one of the most common pathogens of community-acquired pneumonia (CAP) in children. Although Mycoplasma pneumoniae pneumonia (MPP) is considered a self-limiting disease, severe MPP (SMPP) occurs in some cases. This study aims to analyze clinical features of MPP and to explore predictive indicators in the early stage of M. pneumoniae infection.MethodsWe retrospectively enrolled patients with MPP and non-MPP (NMPP) hospitalized to the Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from 2023 to 2024. A total of 757 children with CAP were divided into MPP group and NMPP group. Patients with MPP included SMPP group and mild MPP (MMPP) group. Demographic and clinical characteristics as well as laboratory and imaging tests were deemed to be baseline data within 24 h after admission. We compared differences between MPP group and NMPP group as well as SMPP group and MMPP group. To exclude the impacts of age and gender, analysis of covariance and Logical regression was used to account for the baseline differences in the probability between MPP group and NMPP group, SMPP group and MMPP group. Logistic regression analysis was used to screen markers as potential early clinical predictors. ROC curves were applied to estimate the diagnostic and predictive value of different indicators for SMPP group.ResultsAmong the 757 cases of CAP, 464 cases were MPP group and 226 cases were SMPP group. There were significant differences in hospital stay and fever duration between the MPP and NMPP groups. Compared to NMPP group, MPP group exhibited higher levels of platelet count (PLT), heparin-binding protein (HBP), erythrocyte sedimentation rate (ESR), immunoglobulin G (IgG) (P &lt; 0.05). The levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum ferritin (SF), prothrombin time (PT), fibrinogen (Fg), interleukin-5 (IL-5) and Gamma interferon (IFN-γ) were significantly increased in SMPP group compared to MMPP group. PT, Fg, SF, IL-5 and IFN-γ were independent risk factors for SMPP group. Significantly, IL-5 and IFN-γ served as reliable predictive indices of SMPP.ConclusionsNotable differences were observed in both clinical characteristics and serum inflammatory markers between the MPP group and the NMPP group, as well as between the SMPP group and the MMPP group. Consequently, PT, Fg, SF, IL-5 and IFN-γ hold the potential to be employed as efficacious predictors for SMPP.
Medication non-adherence: reflecting on two decades since WHO adherence report and setting goals for the next twenty years
Authors: Kardas Przemyslaw , Bennett Bryan , Borah Bijan , Burnier Michel , Daly Christopher , Hiligsmann Mickael , Menditto Enrica , Peterson Andrew M. , Slejko Julia F. , Tóth Krisztina , Unni Elizabeth , Ágh Tamás 
Published: December 2024

BackgroundNon-adherence to medication remains a persistent and significant challenge, with profound implications for patient outcomes and the long-term sustainability of healthcare systems. Two decades ago, the World Health Organization (WHO) dedicated its seminal report to adherence to long-term therapies, catalysing notable changes that advanced both research and practice in medication adherence. The aim of this paper was to identify the most important progress made over the last 2 decades in medication adherence management and to initiate a discussion on future objectives, suggesting priority targets for the next 20 years.MethodsThis research used the WHO adherence model as a theoretical framework, categorizing adherence factors into five dimensions: health system, therapy, condition, patient-related, and socioeconomic. Ten international experts, five from Europe and five from the United States, were assigned to these dimensions and participated in structured online discussions. Initially, based on their desk reviews, experts identified significant achievements and future targets. They then ranked these items and provided feedback through several rounds, ensuring anonymity to minimize bias, ultimately reaching a consensus. This iterative process allowed for the creation of top-ten lists of past achievements and future targets for medication adherence management over the next 20 years.ResultsAnalysis of the top-ranked achievements affirms that notable progress has been made in medication adherence research and practice over the past 20 years, with increased awareness and a surge in dedicated scientific publications. Despite these advancements, non-adherence remains a prevalent issue, underscoring the need for the ongoing implementation of innovative solutions identified in this work, such as novel digital health solutions. Interdisciplinary collaboration and a holistic understanding of patient behaviours and socio-economic factors are crucial.ConclusionWhile refraining from imposing a rigid “adherence Decalogue,” we are confident that this overview of recent achievements and the curated selection of future targets may provide a useful foundation for further discussions aimed at advancing medication adherence management. Our results call for a paradigm shift, advocating the repositioning of medication adherence on national agendas and underscoring the necessity for an adherence-supportive ecosystem that extends beyond mere patient support.
Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model
Authors: Proud Emma K. , Rodríguez-Ruiz Mar , Gummerson Dana M. , Vanin Sebastian , Hardy Daniel B. , Rushlow Walter J. , Laviolette Steven R. 
Published: December 2024

IntroductionPrenatal nicotine exposure (PNE) from maternal smoking disrupts regulatory processes vital to fetal development. These changes result in long-term behavioral impairments, including mood and anxiety disorders, that manifest later in life. However, the relationship underlying PNE, and the underpinnings of mood and anxiety molecular and transcriptomic phenotypes remains elusive.MethodsTo model nicotine exposure during prenatal development, our study used human cerebral organoids that were chronically exposed to nicotine and collected for molecular analyses.ResultsShort-term, nicotine altered molecular markers of neural identity, mood and anxiety disorders and those involved in maintaining the excitatory/inhibitory (E/I) balance in the cortex. RNA sequencing further revealed transcriptomic changes in genes pertaining to embryonic development, neurogenesis, and DNA binding. Long-term, mature organoids demonstrated similar disruptions in E/I balance, decreased expression of neural identity markers, and altered dopamine receptor expression.DiscussionCollectively, our results demonstrate that nicotine-induced alterations occur acutely and persist at later stages of development. These findings validate an in vitro model of PNE to better comprehend the emergence of neuropsychiatric molecular and transcriptomic endophenotypes resulting from gestational nicotine exposure.
Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding
Authors: Pejšková Lucie , Pisconti Addolorata , Lunde Marianne , Ho Ka Yi , Solberg Nina Therese , Koga Shiori , Tengstrand Erik , Carlson Cathrine Rein , Pedersen Mona Elisabeth , Rønning Sissel Beate 
Published: December 2024

IntroductionSkeletal muscle satellite cells (MuSCs or stem cells) play a crucial role in muscle development, maintenance, and regeneration, supporting both hypertrophy and regenerative myogenesis. Syndecans (SDCs) act as communication bridges within the muscle microenvironment, regulating interactions with extracellular matrix components and contributing significantly to tissue repair and inflammation. Specifically, syndecan-4 (SDC4) is involved in muscle regeneration at multiple stages.MethodsThis study delves into the emerging challenge of wooden breast (WB) myopathy and its connection with SDC4. Our hypothesis proposes that disruptions in MuSC dynamics through SDC4 contribute to the increased incidence of breast myopathies observed in growing broilers. To test our hypothesis, non-affected and affected broilers were systematically selected, and the characteristics of WB myopathy were studied both in vitro and in vivo. SDC4 overexpression in MuSCs and blocking peptides (BPs) corresponding to the SDC4 ectodomain were used for investigating the role of SDC4 in muscle development and its shedding levels.Results and discussionIn vivo examination of affected muscles revealed smaller fibers and changes in metabolic pathways. In vitro studies unveiled disrupted proliferation of MuSCs in WB myopathy, accompanied by the downregulation of several muscle markers. Investigation of the potential role of SDC4 in the pathogenesis of WB myopathy revealed a decreased tendency in SDC4 gene expression and increased shedding of its ectodomain. Moreover, we showed that SDC4 overexpression is linked to reduced proliferation in MuSCs and affected myogenesis. We detected an impaired proliferation of WB-affected MuSCs, revealing critical insights into the dysfunctional state of these cells in myopathy. Additionally, by treating MuSCs with blocking peptides derived from the SDC4 ectodomain, we identified altered proliferation. Taken together, this work contributes with valuable knowledge on the molecular mechanisms underlying WB myopathy and the role of SDC4 in this chicken myopathy.
The effect of plasma-treated nutrient solution on yield, pigments, and mineral content of rocket [Diplotaxis tenuifolia (L.) DC.] grown under different nitrogen fertilization levels
Authors: Sodini Mirko , Traversari Silvia , Cacini Sonia , Gonfiotti Irene , Lenzi Anna , Massa Daniele 
Published: December 2024

IntroductionThe non-thermal plasma (NTP) technique has been suggested as a sustainable horticultural practice to promote biomass accumulation, nutrient uptake, N metabolism, and disease prevention in plants. In particular, the potentiality of this technique to promote the natural accumulation of nutrients into plants deserve to be explored as input saving is strongly recommended in the horticultural sector.MethodsThe nutrient solution supplied to a red coloured variety of rocket salad [Diplotaxis tenuifolia (L.) DC. ‘Dragon’s Tongue’] grown in a hydroponic close loop system was treated with NTP. Low, medium, and high concentrations of N (i.e., 1, 10, and 20 mM) of the nutrient solution were tested in control (no NTP) or NTP treated conditions in two consecutive growing cycles. Results and discussionResults highlighted a N-dependent effect of NTP treatment showing a biomass stimulation at 10 mM N while negative effects of this technique at 1 and 20mM N. The biomass boosting of NTP found at 10 mMN coupled with an increase in K and Zn showing positive effects also on the nutraceutical aspects. Interestingly, different mechanisms seemed to be involved in the detrimental effects found at low and high N levels, i.e., a lower sensibility to N deficiency at 1 mM and a synergic negative effect of N and NTP in promoting oxidative stress at 20 mM.
Effect of passion on the athlete engagement of college students specializing in DanceSport: the mediating role of the DanceSport partnership
Authors: Ziyou Huang , Yuxin Yuan , Xiaofen Li 
Published: December 2024

ObjectiveThis research investigates the influence of passion on DanceSport engagement (DSE) among university students specializing in DanceSport, along with the mediating function of DanceSport partnership (DSP).MethodsA survey involving 1,029 participants was conducted using the Passion Scale, Athlete Engagement Questionnaire, and Chinese DanceSport Partnership Scale.ResultsThere were significant positive associations among passion, DSP, and DSE. The path coefficient revealed that passion had a 0.631 (p &lt; 0.001) effect on DSE, a 0.548 (p &lt; 0.001) effect on DSP, and DSP had a 0.217 (p &lt; 0.001) effect on DSE. The direct impact of passion on DSE was 0.725, while the indirect impact was calculated at 0.137, resulting in a total effect of 0.862.ConclusionPassion was identified as an internal motivator enhancing DSE, whereas DSP was found to be an external factor contributing to the increase in DSE levels. DSP played a partial mediating role in the influence of passion on DSE, the more harmonious the DSP, the higher the engagement level. In the future, by understanding the current status and trends of college students’ passion, DSE, and DSP, coaches can timely adjust course content to enhance engagement levels and sports performance by exchanging partners and changing cooperation forms.
Association between weekday sleep, weekday-weekend sleep duration gap, and hypertension in American adolescents: a nationwide cross-sectional study
Authors: Luo Yan , Li Qingyuan , Feng Tong , Duan Ran , Chen Yingyi 
Published: December 2024

BackgroundThe increasing prevalence of primary hypertension among children and adolescents is a global health concern, with inadequate sleep duration identified as a significant risk factor. This study investigates the impact of weekday-weekend sleep duration gap (WWSDG) on hypertension among American adolescents.MethodsUsing data from the NHANES 2017-2020 cohort, we analyzed sleep patterns and hypertension prevalence among 430 adolescents. Sleep durations on weekdays and weekends were used to calculate WWSDG. Hypertension was defined according to the American Academy of Pediatrics guidelines.ResultsThe study found that among 430 American adolescents, shorter weekday sleep duration (less than 8 hours) was significantly associated with an increased risk of hypertension (OR: 1.092, 95% CI: 1.042–1.144), while extended weekend sleep did not show a protective effect. Additionally, longer total weekly sleep duration (over 10 hours) was linked to a reduced risk of hypertension, but the difference in sleep duration between weekdays and weekends was not significantly correlated with hypertension risk.ConclusionsThe study highlighted that insufficient weekday sleep duration significantly increases hypertension risk among adolescents. Contrary to popular belief, compensating for sleep deprivation through extended WWSDG did not mitigate this risk. Public health interventions should focus on promoting consistent and adequate sleep throughout the week for cardiovascular health benefits in adolescents. Further longitudinal research is necessary to explore causal relationships and the long-term effects of sleep variability on health outcomes.
Macro-level socioeconomic factors and mental health in midlife and older adults in China: a multilevel analysis
Authors: Li Guannan , Tampubolon Gindo , Maharani Asri , Tu Chenglin 
Published: December 2024

ObjectiveThis study explores the associations between four macro-level factors—Economic Development (ED), Economic Inequality (EI), Governmental Willingness and capacities to invest in Public Health (GWPH) and Public Health-Related Infrastructures (PHRI)—and three mental health indicators: depressive symptoms, cognitive function and life satisfaction, among middle-aged and older adults in China.Materials and methodsWe obtained individual-level data from the Harmonised China Health and Retirement Longitudinal Survey (H-CHARLS) 2018 and acquired our provincial-level data from the Chinese Statistical Yearbook. Two-level linear mixed models are used to examine the associations. Supplementary analyses are carried out to test the robustness of the study.ResultsThere are provincial variations in macro-level factors. Depressive symptoms and cognitive functions also vary across provinces, whereas life satisfaction does not. We find that ED contributes to better depressive status. EI contributes to worse cognitive functions and life dissatisfaction. GWPH and PHRI are not associated with mental health.ConclusionThe study suggests that macro-level ED contributes to better depressive status. EI and potential systematic inequality lead to worsened cognitive functions and life dissatisfaction. It is too soon to generalise whether institutional factors like GWPH and PHRI are good or bad for mental health, but the current public health system in China does not adequately support mental and cognitive health.
The challenge of home and community older adult care in China: a survey of the capability of primary care physicians in providing geriatric healthcare services
Authors: Chen Xiufang , Xie Kun , Li Yahui , Hu Dan , Chen Yong , Chen Jiaying 
Published: December 2024

IntroductionIn the context of ageing at home and in the community, healthcare services for older adult people in China are mainly provided by primary care physicians (PCPs). This study aimed to understand the level of geriatric healthcare service capability of PCPs in China and to give recommendations for improving care.MethodsWe surveyed PCPs in the eastern, central, and western regions of China, using a combination of multi-stage stratified cluster sampling and typical sampling. We evaluated the capability of PCPs in geriatric healthcare services in terms of diagnosis and treatment of common diseases, health management of the older adult, and health management of patients with chronic diseases. We compared the capability of PCPs in different regions, in urban and rural areas, and with different characteristics.ResultsWe found that Chinese primary care doctors had a low level of education and tended to be older in age. We also found a lack of general practitioners in China. Among the 8,469 respondents, 6,497 (76.7%) could diagnose and treat common diseases; 7,755 (91.6%) were capable of managing the health of the older adult, and 7,787 (91.9%) could manage the health of patients with chronic diseases.ConclusionResults indicated that China’s primary care physician workforce was of low quality. There were deficiencies in all competencies in geriatric healthcare services, and there were differences in capability between urban and rural areas. The findings suggest China’s primary healthcare services should be strengthened with targeted training and an emphasis should be placed on developing basic skills in geriatric healthcare services.