bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting nutrition–labor productivity link: new empirical evidence from farm households in Ethiopia
Authors: Berha Andu Nesrey , Mogess Yohannes Kefale , Wassie Mengistu Alamneh 
Published: October 2021

Abstract
Background
Among others, the productive use of surplus labor is a viable mechanism to transform the agricultural sector and thus the whole economy in low-income countries. It is critically important to understand the factors that condition labor productivity to design and deploy effective agricultural and labor market policies. A few studies confirm that, at low-income levels, improving nutrition can contribute to the labor productivity of households. These studies rely heavily on self-reported farm data, which are prone to systematic and random measurement errors. The empirical evidence on this topic remains inadequate and inconclusive for this reason. Here, we substantiate whether better nutritional status enhances the labor productivity of farm households using objective measures of plot-level data from a recent household survey in Ethiopia. We also employ alternative measures of nutrition status indicators known as, Food Consumption Score (FCS) and Household Dietary Diversity Score (HDDS), inter alia, to capture additional aspects of nutrition such as diet quality and diversity, which are overlooked by calorie intake data. To deal with possible endogeneity, we employ a panel fixed effect estimation technique with a rich set of household socioeconomic and plot characteristics.

Results
We observe that the impact of current nutritional status, as measured by HDDS, on labor productivity varies considerably depending on the initial level of diet quality and diversity with a stronger and positive effect for low-consumption households. In an alternative specification, we also observe a positive farm labor productivity effect of current nutritional status as measured by FCS with a homogenous effect across households. However, the effect of the outcome of past nutritional status as evaluated by the Activity of Daily Living Index (ADLI) seems negligible.

Conclusion
Our findings indicate that improving nutrition can contribute to farm labor productivity at least for households with low current diet quality and diversity. Also, based on the findings, we conclude that there is a possibility of a low consumption–low productivity trap in Ethiopia.
WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka
Authors: Galappatthy P. , Ranasinghe P. , Liyanage C. K. , Wijayabandara M. S. , Mythily S. , Jayakody R. L. 
Published: October 2021

Abstract
Background
Identification of internationally comparable indicators of medicines use are important for a country to implement strategies and regulations to improve usage of medicines. Sri Lanka established a new National Medicines Regulatory Authority in 2015 and this survey evaluated the medication use indicators in Sri Lanka, according to the International Network on Rational Use of Drugs (INRUD), prior to its implementation.

Methods
This descriptive-cross-sectional study was conducted in 80 pharmacies, representing all 25 districts of the country. Three pharmacy categories were included; privately owned pharmacies, ‘Rajya Osusala’ pharmacies operated by the State Pharmaceuticals Corporation (SPC) of Sri Lanka and SPC Franchisee pharmacy outlets. Selection of pharmacies from respective districts were done proportionate to estimated population. Data were collected to identify WHO/INRUD core drug use indicators and the commonly prescribed medicines.

Results
Total of 2328 prescriptions were included (‘Rajya Osusala 559; SPC Franchise 711; private pharmacies 1058). Altogether 7,255 medicines were prescribed, and the 3 most commonly prescribed medicines were atorvastatin, losartan and metformin. Average number of medicines per encounter was 3.1±1.9 (Median: 3; range 1-12) Highest average number of medicines per encounter was reported in prescriptions received at ‘Rajya Osusala’ pharmacies (3.6±2.2), significantly higher than in other categories of pharmacies (p<0.001). Percentage of medicines prescribed by generic name was only 35.5%, highest at the ‘Rajya Osusala’ pharmacies (40.6%), significantly higher than other categories of pharmacies. The overall percentage of medicines prescribed from essential medicine list (EML) was 68.8%, without any significant variation between different categories of pharmacies. The percentage of medicines actually dispensed and accurately labelled were 92.4 and 98.5% respectively.

Conclusions
The average number of medicines per encounter was higher than the WHO recommended value but the usage of antibiotic and injectable drugs were within recommended standards. Generic prescribing, was very much lower. The EML prescribing, labelling and percentage dispensed medicines fared much better although lower than the WHO recommended 100% compliance. This island wide study has provided national wide data before the implementation of key changes in regulation of medicines in Sri Lanka and a repeat survey will be useful to identify impact of the new legislations.
A multi-responsive coumarin–benzothiazole fluorescent probe for selective detection of biological thiols and hydrazine
Authors: Chen Kangni , Li Yanbo , Shang Jinyan , Li Heping 
Published: October 2021

AbstractBiothiols play important roles in various physiological and biological processes, which closely related to many diseases. Hydrazine is widely used in the chemical industry, but it is harmful to humans and animals. Therefore, it is very important to develop a fluorescent probe that can simultaneously detect biological thiols and hydrazine. In this work, a new fluorescent probe (2E,4Z)-2-(benzo[d]thiazol-2-yl)-5-chloro-5-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)penta-2,4-dienenitrile (BCD) was synthesized by integrating coumarin and benzothiazole acetonitrile. Featured with four binding sites and different bonding mechanism between probe with biothiols and hydrazine, this probe exhibited fluorescent turn-on for distinguishing Cys, Hcy, GSH and hydrazine with 760-, 8-, 6- and 637-fold fluorescent intensity increase at 502, 479, 476 and 458 nm, respectively, through different excitation wavelengths. Research on the effect of pH on the fluorescent performance of BCD shows that the probe exhibits superior stability in a weakly alkaline to weakly acidic environment, which will facilitate the detection of biological thiols or hydrazine hydrate by BCD. Selectivity studies have shown that the probe has high specificity to biological thiols and hydrazine, which is of great significance to the application of BCD.
Magnetic resonance imaging of pure ovarian dysgerminoma: a series of eight cases
Authors: Cacioppa Laura Maria , Crusco Federico , Marchetti Francesco , Duranti Michele , Renzulli Matteo , Golfieri Rita 
Published: October 2021

Abstract
Background
Imaging findings have a prominent role in early and correct identification of ovarian dysgerminoma, the most common ovarian malignant germ cell tumor (OMGCT). Despite Computed Tomography (CT) is widely used, Magnetic Resonance Imaging (MRI) has proved to be superior in adnexal masses characterization. Limited data and small series are available concerning MRI aspects of dysgerminoma.

Case presentation
From January 2012 to December 2018, a database of solid ovarian masses was retrospectively reviewed. Eight patients with histologically proven pure ovarian dysgerminoma and complete imaging available were identified and analyzed. Imaging findings were evaluated separately by two radiologists expert in female genito-urinary MRI.

Conclusions
MRI findings of a lobulated, purely solid, encapsulated mass with hyper-intensity of lobules and hypo-intensity of septa on T2w images contribute to differentiate dysgerminomas from other ovarian neoplasms.
Shipping optimization systems (SOS) for tramp: stochastic cargo soft time windows
Authors: El Noshokaty Said 
Published: October 2021

AbstractCargo time windows have been discussed in the shipping literature in several ways and within several contexts. One way considers the hard time windows, where a fixed date is assigned to both the open and close laycan for the cargo loading and discharging ports. According to this way, the cargo is rejected if the ship cannot meet these time windows. Another way develops soft time windows, where the ship for an additional cost or a penalty may violate the cargo laycan. The context in the previous ways includes a tramp deterministic model. In this paper, the soft time windows are considered within a context of a tramp stochastic model, where both the cargo transport demand and the laycan dates are random variables. The objective is a gross-profit-per-day accompanied with realistic shipping elements embedded into decision support systems known as shipping optimization systems (SOS). The chance-constraint programming and the modified version of the Dantzig–Wolfe decomposition principle known as block-angular linear ratio programming solve the problem. A case study demonstrates that using stochastic soft time windows with stochastic cargo transport demand has considerably improved the gross profit-per-day better than trying to arrive on time by varying ship speed or being within a non-stochastic shipping context.
A workflow to generate patient-specific three-dimensional augmented reality models from medical imaging data and example applications in urologic oncology
Authors: Wake Nicole , Rosenkrantz Andrew B. , Huang William C. , Wysock James S. , Taneja Samir S. , Sodickson Daniel K. , Chandarana Hersh 
Published: October 2021

AbstractAugmented reality (AR) and virtual reality (VR) are burgeoning technologies that have the potential to greatly enhance patient care. Visualizing patient-specific three-dimensional (3D) imaging data in these enhanced virtual environments may improve surgeons’ understanding of anatomy and surgical pathology, thereby allowing for improved surgical planning, superior intra-operative guidance, and ultimately improved patient care. It is important that radiologists are familiar with these technologies, especially since the number of institutions utilizing VR and AR is increasing. This article gives an overview of AR and VR and describes the workflow required to create anatomical 3D models for use in AR using the Microsoft HoloLens device. Case examples in urologic oncology (prostate cancer and renal cancer) are provided which depict how AR has been used to guide surgery at our institution.
Role of collagen degradation pathway in sphingomyelin synthase 2-deficient mouse skin
Authors: Hiranuma Takenaga , Watanabe Ken , Yamashita Tadashi , Okazaki Toshiro , Tokudome Yoshihiro 
Published: October 2021

Abstract
Background
Sphingomyelin synthase (SMS) is the only enzyme that synthesizes sphingomyelin from ceramide. The role of sphingomyelin synthase in epidermis is being understood, but there is no report on its role in the dermis. Quantitative and qualitative evaluation of collagen in SMS2-deficient mice reveals the role of SMS2 in collagen production.

Methods
SMS2-deficient mice were used for in this study. The dermis thickness was measured by Elastica van Gieson staining, the collagen fiber was observed by Scanning Electron Microscopy, the collagen content by ELISA, the ceramide and sphingomyelin content by Thin Layer Chromatography, the collagen-generating and metabolizing gene expression level by RT-PCR, and MMP13 protein level was measured by western blotting.

Results
Thinner dermis in these mice compared to wild-type mice. A reduced number of collagen fibers were observed, and decreased levels of type I collagen and sphingolipids. Gene expression levels of collagen production-related genes in the dermis were found to be unaltered. The expression of several genes related to collagen degradation was found to be affected. The expression level of TNFα and MMP13 and MMP13 protein levels were increased relative to those of wild-type mice, while the expression level of TIMP1 was decreased.

Conclusions
These results indicate that SMS is involved not only in maintaining the sphingolipid content of the epidermal barrier but also in maintaining collagen homeostasis. Further elucidation of the role of SMS2 in the skin may lead to SMS2 comprising a new target for the treatment of skin diseases and the development of functional cosmetics.
Influence of phosphorus and nitrogen co-doping of activated carbon from littered cigarette filters for adsorption of methylene blue dye from wastewater
Authors: Macchi Samantha , Alsebai Zane , Watanabe Fumiya , Ilyas Arooba , Atif Shiraz , Viswanathan Tito , Siraj Noureen 
Published: October 2021

AbstractGlobal access to sanitary water is of utmost importance to human health. Presently, textile dye water pollution and cigarette pollution are both plaguing the environment. Herein, waste cigarette filters (CFs) are converted into useful carbon-based adsorbent materials via a facile, microwave-assisted carbonization procedure. The CFs are activated and co-doped with phosphorus and nitrogen simultaneously to enhance their surface characteristics and adsorbent capability by introducing chemisorptive binding sites to the surface. The doped carbonized CF (DCCF) and undoped carbonized CF (CCF) adsorbents are characterized physically to examine their surface area, elemental composition, and surface charge properties. The maximum adsorption capacity of synthesized adsorbents was determined via batch adsorption experiments and Langmuir modelling. Additionally, the influence of different parameters on the adsorption process was studied by varying the adsorption conditions such as adsorbent dosage, initial concentration, contact time, temperature, and pH. The DCCF adsorbent showed a maximum adsorption capacity of 303 mg g− 1. Adsorption of both adsorbents fit best to Langmuir model and pseudo-second order kinetics, indicating chemisorptive mechanism. Both adsorbents showed endothermic adsorption process which is indicated by increasing adsorption capacity with increased temperatures. DCCF exhibited greater adsorption capability than CCF at all temperatures from 25 to 55 °C. The pH of the solution significantly affected the adsorption capacity of CCF while DCCF adsorption is favorable at a wide pH range due to low value of the adsorbent’s point of zero charge. Reusability results showed that both adsorbents can be used over several cycles for removal of dye. Thus, results conclude that the waste DCCF-based adsorbent does not only show a profound potential as a sustainable solution to combat textile dye water pollution but also addresses the valuable use of the CF pollution simultaneously. This approach, which can target two major pollutants, is attractive due to its ease of preparation, negligible cost, and versatility in application.
Association of LH/FSH ratio with menstrual cycle regularity and clinical features of patients with polycystic ovary syndrome
Authors: Mitrašinović-Brulić Maja , Buljan Mihaela , Suljević Damir 
Published: October 2021

Abstract
Background
Understanding the global prevalence and phenotypic features of polycystic ovary syndrome (PCOS) is important as geographic factors and ethnic variations can significantly alter the clinical syndrome. The aim of this study was to determine and evaluate the luteinizing hormone/follicle-stimulating hormone ratio (LH/FSH) in women with PCOS during therapy on selected endocrine and biochemical parameters.

Results
Women with PCOS were included in the study and were classified into two groups: women without therapy (de novo) and women with therapy for PCOS. ESHERE/ASRM criteria that require the presence of two out of three criteria: ovulatory dysfunction, hyperandrogenism, and morphological PCOS detected by ultrasound diagnostics. Electrochemiluminescence immunoassay (ECLIA) was used for FSH and insulin analysis. The enzymatic method was used to analyze the biochemical profile. There was a significant difference between the two groups in terms of the LH/FSH ratio (2.56 vs. 2.41, P=0.043), glucose (6.23 vs. 5.12, P=0.003), insulin (19.21 vs. 7.35, P=0.000), IR (3.22 vs. 1.42, P=0.000), cholesterol (5.97 vs. 4.92, P=0.002), and LDL (3.56 vs. 2.56, P=0.001). The data suggest that patients with PCOS therapy have reduced hyperinsulinemia and insulin resistance. There was a significant correlation between the LH and FSH in the de novo group, as well as the correlation between hormone levels and LH/FSH ratio in both groups. Patients with PCOS therapy have a tendency for normal body weight and reduction of severe obesity compared to patients without therapy. Clinical features such as regular menstrual cycle and the prevalence of acne and hirsutism are not significantly different between groups.

Conclusion
PCOS cause irregularities of the menstrual cycle, the appearance of clinical manifestations, especially changes of LH/FSH ratio. Therapy for PCOS contributes to better regulation of endocrine and biochemical parameters, especially in the reduction of hyperinsulinemia, insulin resistance, and reduced LH/FSH ratio.
Learning from the “tail end” of de-implementation: the case of chemical castration for localized prostate cancer
Authors: Skolarus Ted A. , Forman Jane , Sparks Jordan B. , Metreger Tabitha , Hawley Sarah T. , Caram Megan V. , Dossett Lesly , Paniagua-Cruz Alan , Makarov Danil V. , Leppert John T. , Shelton Jeremy B. , Stensland Kristian D. , Hollenbeck Brent K. , Shahinian Vahakn , Sales Anne E. , Wittmann Daniela A. 
Published: October 2021

Abstract
Background
Men with prostate cancer are often treated with the suppression of testosterone through long-acting injectable drugs termed chemical castration or androgen deprivation therapy (ADT). In most cases, ADT is not an appropriate treatment for localized prostate cancer, indicating low-value care. Guided by the Theoretical Domains Framework (TDF) and the Behavior Change Wheel’s Capability, Opportunity, Motivation Model (COM-B), we conducted a qualitative study to identify behavioral determinants of low-value ADT use to manage localized prostate cancer, and theory-based opportunities for de-implementation strategy development.

Methods
We used national cancer registry and administrative data from 2016 to 2017 to examine the variation in low-value ADT use across Veterans Health Administration facilities. Using purposive sampling, we selected high- and low-performing sites to conduct 20 urology provider interviews regarding low-value ADT. We coded transcripts into TDF domains and mapped content to the COM-B model to generate a conceptual framework for addressing low-value ADT practices.

Results
Our interview findings reflected provider perspectives on prescribing ADT as low-value localized prostate cancer treatment, including barriers and facilitators to de-implementing low-value ADT. We characterized providers as belonging in 1 of 3 categories with respect to low-value ADT use: 1) never prescribe 2); willing, under some circumstances, to prescribe: and 3) prescribe as an acceptable treatment option. Provider capability to prescribe low-value ADT depended on their knowledge of localized prostate cancer treatment options (knowledge) coupled with interpersonal skills to engage patients in educational discussion (skills). Provider opportunity to prescribe low-value ADT centered on the environmental resources to inform ADT decisions (e.g., multi-disciplinary review), perceived guideline availability, and social roles and influences regarding ADT practices, such as prior training. Provider motivation involved goals of ADT use, including patient preferences, beliefs in capabilities/professional confidence, and beliefs about the consequences of prescribing or not prescribing ADT.

Conclusions
Use of the TDF domains and the COM-B model enabled us to conceptualize provider behavior with respect to low-value ADT use and clarify possible areas for intervention to effect de-implementation of low-value ADT prescribing in localized prostate cancer.

Trial registration
ClinicalTrials.gov, NCT03579680
Audit feedback interventions to address high-risk prescriptions in long-term care homes: a costing study and return on investment analysis
Authors: Thavorn Kednapa , Kumar Srishti , Reis Catherine , Lam Jonathan , Dobell Gail , Mulhall Cara , Grimshaw Jeremy M. , Ivers Noah 
Published: October 2021

Abstract
Background
Audit and feedback is a common implementation strategy, but few studies describe its costs. ‘MyPractice’ is a province-wide audit and feedback initiative to improve prescribing in nursing homes. This study sought to estimate the costs of ‘MyPractice’ and assess whether the financial benefit of ‘MyPractice’ offsets those costs.

Methods
We conducted a costing study from the perspective of the Ontario government. Total cost of ‘MyPractice’ was calculated as the sum of the costs of producing and disseminating the reports (covering three report releases) which were obtained from Ontario Health staff interviews and document reviews. Return on investment (ROI) was calculated as the ratio of net cost-savings and the intervention cost. Cost savings were based on the effectiveness of ‘MyPractice’ derived from a published cohort study. Cost-savings attributable to ‘MyPractice’ were estimated from the changes in the rates of antipsychotics over time between physicians who signed up and viewed the reports and those who did not sign up to the reports.

Results
Total intervention costs were C$223,691 (C$838 per physician and C$74,564 per release). Costs incurred during the development phase accounted for 74% of the total cost (C$166,117), while implementation costs for three report releases were responsible for 26% of the total costs (C$57,575). The ROI for every C$1 spent on the ‘MyPractice’ intervention was 1.02 (95% CI 0.51, 1.93) for three report releases.

Conclusion
‘MyPractice’ report offers a good return on investment and the value for money could improve with greater number of report releases.
Digital gangrene as an unusual paraneoplastic manifestation of hodgkins lymphoma—a rare case report
Authors: Deme Swaroopa , Kakarla Bhaskar , P. Venkateswar Rao , YSN Raju , M. Nageswara Rao 
Published: October 2021

Abstract
Background
Hodgkin’s lymphoma presenting with digital ischemia and gangrene is a rare manifestation. Paraneoplastic manifestations are rare in Hodgkin’s lymphoma but can occur in the form of paraneoplastic cerebellar degeneration (PCD) and dermatomyositis/polymyositis. This case report adds an exceptional presentation of Hodgkin's lymphoma as digital ischemia and gangrene.

Case presentation
We report a case of a 60-year-old male patient who presented with fever, cough, shortness of breath, the pain in the right middle finger. On examination bluish-black discoloration of the right middle finger, left middle finger, ring finger, and generalized lymphadenopathy was noted. On further evaluation, he was found to have anemia, eosinophilia, and severe thrombocytopenia with a normal coagulation profile and negative rheumatological workup. Arterial Doppler of both upper limbs showed the normal study. He was diagnosed to have Hodgkin’s lymphoma on the lymph node and bone marrow biopsy. He was started on chemotherapy with partial improvement in symptoms and was lost to follow-up after 2 cycles.

Conclusions
Digital ischemia can be a rare paraneoplastic manifestation of Hodgkin’s lymphoma.