bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Persian version of the centrality of event scale (CES): Assessment of validity and reliability among Iranian university students
Authors: Azadfar Zahra , Khosravi Zohreh , Farah Bijari Azam , Abdollahi Abbas 
Published: November 2021

AbstractBackgroundEvent centrality, the extent to which an experience is perceived as a central event in one's life, has been found to be a strong correlate of posttraumatic stress disorder (PTSD). The centrality of event scale (CES) is commonly used in different conditions and cultures to measure trauma‐related effects. However, the psychometric properties of this scale have not been investigated in the Iranian context.MethodsThe present study examined the psychometric properties of the Persian translation of the 7‐item CES in a sample of 525 university students with a history of a romantic breakup.ResultsConfirmatory factor analysis confirmed a one‐factor structure. The CES score was positively correlated with psychological inflexibility and PTSD symptoms. The measurement invariance analyses showed that the 7‐item CES is gender invariant and can be used for both men and women.FindingsFindings supported the good psychometric properties of the 7‐item CES for measuring event centrality in Iranian university students.
Development of a novel cell line‐derived xenograft model of primary herpesvirus 8‐unrelated effusion large B‐cell lymphoma and antitumor activity of birabresib in vitro and in vivo
Authors: Nishimori Tomohiro , Higuchi Tomonori , Hashida Yumiko , Ujihara Takako , Taniguchi Ayuko , Ogasawara Fumiya , Kitamura Naoya , Murakami Ichiro , Kojima Kensuke , Daibata Masanori 
Published: November 2021

AbstractBackgroundPrimary human herpesvirus 8 (HHV8)‐unrelated effusion large B‐cell lymphoma is a clinical disease entity distinct from HHV8‐positive primary effusion lymphoma (PEL). However, the lack of experimental HHV8‐unrelated effusion large B‐cell lymphoma models continues to hinder the pathophysiologic and therapeutic investigations of this disorder.MethodsThe lymphoma cells were obtained from the pleural effusion of a patient with primary HHV8‐unrelated effusion large B‐cell lymphoma and cultured in vitro.ResultsWe established a novel HHV8‐unrelated effusion large B‐cell lymphoma cell line, designated Pell‐1, carrying a c‐MYC rearrangement with features distinct from those of HHV8‐positive PEL. Moreover, we developed an HHV8‐unrelated effusion large B‐cell lymphoma cell line‐derived xenograft model. Pell‐1 cells induced profuse lymphomatous ascites and subsequently formed intra‐abdominal tumors after intraperitoneal implantation into irradiated nonobese diabetic/severe combined immunodeficient mice. Thus, this xenograft mouse model mimicked the clinical phenomena observed in patients and recapitulated the sequential stages of aggressive HHV8‐unrelated effusion large B‐cell lymphoma. The bromodomain and extraterminal domain (BET) inhibitors JQ1 and birabresib (MK‐8628/OTX015) reduced the proliferation of Pell‐1 cells in vitro through the induction of cell cycle arrest and apoptosis. The antitumor effect of BET inhibition was also demonstrated in vivo, as birabresib significantly reduced ascites and suppressed tumor progression without apparent adverse effects in the xenografted mice.ConclusionThese preclinical findings suggest the therapeutic potential of targeting c‐MYC through BET inhibition in HHV8‐unrelated effusion large B‐cell lymphoma.
Comparison of survival, acute toxicities, and dose–volume parameters between intensity‐modulated radiotherapy with or without internal target volume delineation method and three‐dimensional conformal radiotherapy in cervical cancer patients: A retrospective and propensity score‐matched analysis
Authors: Liang Yu‐Qin , Feng Sen‐Quan , Xie Wen‐Jia , Jiang Qiong‐Zhi , Yang Yan‐Fen , Luo Ren , Kidd Elizabeth A. , Zhai Tian‐Tian , Xie Liang‐Xi 
Published: November 2021

AbstractBackgroundTo evaluate whether the use of the internal target volume (ITV) delineation method improves the performance of intensity‐modulated radiotherapy (IMRT) and three‐dimensional conformal radiotherapy (3DCRT) in terms of survival, acute toxicities, and dose–volume parameters.MethodsA total number of 477 cervical cancer patients who received concurrent chemoradiotherapy (CCRT) from January 2012 to December 2016 were retrospectively analyzed. They were divided into four groups: the non‐ITV (N‐ITV) + IMRT, ITV + IMRT, N‐ITV + 3DCRT, and ITV + 3DCRT groups, with 76, 41, 327, and 33 patients, respectively. Survival analysis was performed with the Kaplan–Meier and the log‐rank tests, and acute toxicity analysis was performed with the chi‐squared test and the binary logistic regression test. Using the propensity score matching (PSM) method, 92 patients were matched among the four groups, and their dose–volume parameters were assessed with the Kruskal–Wallis method.ResultsThe median follow‐up time was 49 months (1–119) for overall survival (OS). The 5‐year OS rate was 66.4%. The ITV delineation method was an independent prognostic factor for OS (HR [95% CI]: 0.52 [0.27, 0.98], p = 0.044) and progression‐free survival (PFS) (HR [95% CI]: 0.59 [0.36, 0.99], p = 0.045). The ITV + IMRT group had the lowest incidence rate (22%) and the N‐ITV + IMRT group had the highest incidence rate of grade ≥3 hematological toxicity (HT) (46.1%) among the four groups. The pelvic bone marrow relative V10, V20, and V30 in the N‐ITV + IMRT group was higher than those in the ITV + IMRT and N‐ITV + 3DCRT groups (p < 0.05).ConclusionsThe use of ITV for IMRT treatment planning was associated with improved overall survival and progression‐free survival, with lower HT rate.
Netherton syndrome plus atopic dermatitis: Two new genetic mutations in the same patient
Authors: Moar Agata , Bruni Manfredo , Schena Donatella , Rigotti Erika , Colato Chiara , Novelli Antonio , Cesario Claudia , Girolomoni Giampiero 
Published: November 2021

AbstractA child who comes to our attention for the appearance of erythematous, scaly lesions localized to the upper and lower limbs for 2 months. Histological features suggested ichthyosiform disease and concomitant mutations in the SPINK5 and FLG2 genes confirmed Netherton syndrome with severe atopic manifestations.
Is single‐point acupuncture effective in treating acute low back pain?
Authors: Tiwari Sagun , Sapkota Namrata 
Published: November 2021

AbstractAcupuncture is often used for acute and chronic low back pain; however, its efficacy is controversial, primarily for acute low back pain (ALBP). An acupuncture point, GV‐26, could be used as an analgesic acupoint to treat acute low back pain. Our study suggests that single acupuncture could relieve ALBP within a short time without any adverse events. Acupuncture can be integrated with allopathic (western) medicine and used in the hospital's emergency department to treat acute painful conditions.
Successful implantation of S‐ICD using the intermuscular two‐incision technique in a patient with severe pectus excavatum
Authors: Guarracini Fabrizio , Marini Massimiliano , Strazzanti Mattia , Bonmassari Roberto , Guarracini Stefano , Di Mauro Michele , Droghetti Andrea 
Published: November 2021

AbstractA patient with severe pectus excavatum, dilated ischemic heart disease, and indication for defibrillator implantation for primary prevention of sudden death underwent successful ultrasound‐guided serratus anterior plane block and parasternal block with intermuscular two‐incision technique implantation with no complications. At follow‐up, all the parameters resulted stable with excellent signal sensing.
Mixed Oxygen Ionic and Electronic Conducting Membrane Reactors for Pure Chemicals Production
Authors: Wang Ao , Liang Man , Xiang Qingyun , Xue Jian , Wang Haihui 
Published: November 2021

AbstractTraditional gas separation technologies to produce pure oxygen, hydrogen and highly concentrated nitrogen, such as pressure swing adsorption and cryogenic separation, are cost and energy intensive. The mixed oxygen ionic and electronic conductor (MIEC) membrane can separate oxygen with 100 % selectivity, which can be applied as a platform reactor for pure chemicals production. In the MIEC membrane reactor, pure O2 can be directly produced. When the oxygen is all removed, highly concentrated N2 is generated. Moreover, if the feeding gas is water steam, hydrogen can be yielded through water decomposition. Significant progress has been made in the MIEC membrane reactor for pure chemicals production over the past few years. Therefore, this work summarizes the relative efforts on MIEC membranes for oxygen, nitrogen, and hydrogen purification. The principles of materials selection, membrane morphology optimizing, and reactions coupling are discussed in detail.
Analysis of commonly used scheduling models for multistage biopharmaceutical processes
Authors: Kumar Vaibhav , Shaik Munawar A. , Jain Arpit 
Published: November 2021

AbstractSeveral works have been reported in the literature over the past two decades to schedule a multiproduct facility in the biopharmaceutical industry. The present work attempts to analyze a few commonly used scheduling models, based on different time representations, for midterm planning or long‐term scheduling of multistage, multiproduct biopharmaceutical facilities for multiperiod demand. Several model inconsistencies/limitations in the published literature and in the reported Gantt charts, such as (i) real‐time storage violation, (ii) early product delivery, (iii) inadequate mapping of upstream and downstream tasks, (iv) no initial setup time, and (v) incomplete sequencing/modelling of storage tasks, thus (iv) overestimating the reported objective values in their results, are identified. Accordingly, one of the unit‐specific‐event‐based literature models is improved in this work to address these limitations. An improved model is proposed with enhanced/new features such as modified material balances, proper sequencing of storage based on storage bypassing allowed for intermediates and bypassing not allowed for products, modified shelf‐life constraints, initial setup time constraints, and updated bounds on storage, giving better results compared to the published literature models.
Controllable Synthesis of Silicon‐Based Nanohybrids for Reliable Surface‐Enhanced Raman Scattering Sensing
Authors: Lu Xing , Wang Houyu , He Yao 
Published: November 2021

Comprehensive SummaryInterface between metallic nanoparticles and dielectric silicon substrate can strongly confine electromagnetic field (EM‐field) through its localized surface plasmons, together contributing great surface‐enhanced Raman scattering (SERS) enhancement. Typically, silicon‐based nanohybrids (metallic nanoparticles in situ grown on silicon substrate) have been widely employed as SERS‐active substrates in sensing platforms for the detection of chemical and biological analytes. Silicon‐based nanohybrids with surface plasmons allow amplifying Raman signals that associate molecular binding events by several orders of magnitude. Together with interfacial architectures for the specific binding of target analyte on the silicon‐based nanohybrid surface, silicon‐based nanohybrid‐enhanced Raman scattering represents a promising method for increasing reliability and sensitivity. This review affords a presentation to the basics of SERS enhancement of silicon‐based nanohybrid, illustrates current advances in controllable synthesis of silicon‐based nanohybrid substrates, and outlines current implementations to sensors for reliable detection of ultralow amounts of analytes.
What is the most favorite and original chemistry developed in your research group?The design and fabrication of silicon‐based platform for long‐term bioimaging and reliable biosensing analysis.What is the most important personality for scientific research?Cooperation and conscientiousness.What are your hobbies? What's your favorite book(s)?Music. History book.Who influences you mostly in your life?Family and supervisors.What is your favorite journal(s)?Nature serials, JACS, Angew. Chem., etc.Could you please give us some advices on improving Chinese Journal of Chemistry?Publishing original and significant discoveries.
Self‐assembly into Polymorphic 2D Nanosheets with Crystallization‐Induced Emission Enhancement
Authors: Zhang He , Jin Dong , Lin Dongqing , Huang Lei , Wang Jin , Wang Shasha , Xie Linghai 
Published: November 2021

Comprehensive SummaryOrganic micro/nanocrystals with polymorphic tailorability and perfect platform to modulate decode the complex relationship among molecular structures, supramolecular/noncovalent interactions, aggregates and exciton behaviors. Herein, we precisely tune the polymorphic two‐dimensional organic nanosheets (2DONs) of cyano‐spirocyclic aromatic hydrocarbon (2'‐CN‐SFX), where the crystal growth processes are dominated by precursor concentration. The low concentration (ca. 2 mmol/L) affords the rhombus‐like nanosheets with monoclinic P21/c space group, in which molecules adopt antiparallel and slipped stacking mode. In contrast, the high concentration (ca. 4 mmol/L) favors herringbone‐like molecular packing pattern and then generates shuttle‐like nanosheets with monoclinic C2/c space group. Both above polymorphic nanosheets exhibit unprecedented crystallization‐induced emission enhancement (CIEE) feature that increases the photoluminescence quantum yields (PLQYs) from 16% in solution, 21% in amorphous film to 37%—39% in crystalline states. This result will offer promising opportunities for nanophotonics and organic intelligent semiconductors.
Orthogonality of Redesigned tRNA Molecules with Three Stop Codons
Authors: Zhang Zhao‐Yang , Liao Dan‐Ni , Ma Yu‐Xin , Jia Bin , Yuan Ying‐Jin 
Published: November 2021

Comprehensive SummaryThe ability to expand genetic code in living cells has emerged as a powerful method with diverse applications. Here, we design replacement of the anticodons of E. coli tRNAs that recognize codons for 20 natural amino acids, with three anti‐stop codons, resulting in a total of 60 engineered tRNA constructs. We test these constructs one by one in E. coli, and found that six tRNAsCUA (tyrV, serX, hisR, trpT, glnV and leuX), two tRNAsUCA (trpT and leuX) and one tRNAUUA (tyrV) allowed efficient expression of Red Fluorescence Protein (RFP) with the presence of a corresponding stop codon in frame. Furthermore, we exploit the mutual orthogonality of tRNASerCUA, tRNATrpUCA and tRNATyrUUA with corresponding stop codons and demonstrated that the tRNASerCUA and the tRNATrpUCA can provide dynamic range and low crosstalk. Finally, we show the TAG and TGA can not only be used as an “AND gate” circuit to control the translation of target gene, but also be used to control the translation of a prodeoxyviolacein (PDV) pathway and a reporter in parallel. Overall, this work provides flexible tools for translational control and holds great potential to promote synthetic biology studies.
Mantle cell lymphoma: A clinical review of the changing treatment paradigms with the advent of novel therapies, and an insight into Indian data
Authors: Radhakrishnan Vivek Sulekha , Lokireddy Padmaja , Parihar Mayur , Prakash Prashanth Srirangapattana , Menon Hari 
Published: November 2021

AbstractBackgroundMantle cell lymphoma (MCL) is a rare type of mature B‐cell lymphoid malignancy with the pathologic hallmark of translocation t(11;14) (q13, q32), which leads to an overexpression of Cyclin D1 (CCND1). The disease is also characterized by the presence of a high number of recurrent genetic alterations, which include aberrations in several cellular pathways. MCL is a heterogeneous disease with a wide range of clinical presentations and a majority presenting with aggressive disease in advanced stages.Recent findingsManagement of MCL is bereft with challenges due to its resistant and relapsing pattern. Despite improvements in remission durations, the disease is currently incurable with standard therapy and has a median survival of about 3–5 years. The use of small molecules like the bruton tyrosine kinase (BTK) and BCL2 inhibitors, for treating relapsed MCL has been established leading to a diminishing role for conventional chemotherapy. Combinations of small molecule inhibitors with or without chemoimmunotherapy, are showing promising results. Cellular therapy in the form of CAR‐T cell therapy, has been approved recently.ConclusionsPersonalized cancer treatment and chemo‐free regimens are showing promise and results from well‐planned long‐term studies are evolving. In India, there is a paucity of epidemiological, clinical, and research data in this field.
Therapeutic engagement in robot‐assisted psychological interventions: A systematic review
Authors: Riches Simon , Azevedo Lisa , Vora Alkesh , Kaleva Ina , Taylor Lawson , Guan Peipei , Jeyarajaguru Priyanga , McIntosh Harley , Petrou Constantina , Pisani Sara , Hammond Neil 
Published: November 2021

AbstractPurposeTherapeutic engagement is a key component of psychological interventions. Robot‐assisted psychological interventions appear to have therapeutic benefits for service users that are challenging to engage. However, engagement with robots in robot‐assisted psychological interventions is not well understood. The aim of this systematic review is to evaluate the quality of therapeutic engagement in robot‐assisted psychological interventions (PROSPERO: 122437).MethodsScopus, Web of Science, PsycInfo and Medline were searched until 15 January 2021 for studies which quantitatively evaluated therapeutic engagement in robot‐assisted psychological interventions. The Effective Public Health Practice Project (EPHPP) quality assessment tool was used to assess methodological dimensions of studies.Results3647 studies were identified through database searching. Thirty studies (N = 1462), published between 2004 and 2020, and from 14 countries, were included. Robots were typically toy animals or humanoids and were used to provide support and improve wellbeing through social interaction. Studies primarily tested robots on older adults with dementia and children with autism and indicated positive therapeutic engagement. Twelve studies included a control group. EPHPP ratings were ‘strong’ (N = 1), ‘moderate’ (N = 10) and ‘weak’ (N = 19).ConclusionsTherapeutic engagement between service users and robots is generally positive. Methodological limitations of studies, such as small sample sizes, and lack of control groups and longitudinal data, mean that the field is in early stages of its development and conclusions should be drawn with caution. There are important practical and ethical implications for policymakers to consider, such as responsible clinical practice and how service users may understand the therapeutic relationship with robots.
A OneStep Solution to Fix and Stain Cells for Correlative Live and Fixed Microscopy
Authors: Velle Katrina B. , Fermino do Rosário Carline , Wadsworth Patricia , Fritz‐Laylin Lillian K. 
Published: November 2021

AbstractCorrelating the location of subcellular structures with dynamic cellular behaviors is difficult when working with organisms that lack the molecular genetic tools needed for expressing fluorescent protein fusions. Here, we describe a protocol for fixing, permeabilizing, and staining cells in a single step while imaging on a microscope. In contrast to traditional, multi‐step fixing and staining protocols that take hours, the protocol outlined here achieves satisfactory staining within minutes. This approach takes advantage of well‐characterized small molecules that stain specific subcellular structures, including nuclei, mitochondria, and actin networks. Direct visualization of the entire process allows for rapid optimization of cell fixation and staining, as well as straightforward identification of fixation artifacts. Moreover, live imaging prior to fixation reveals the dynamic history of cellular features, making it particularly useful for model systems without the capacity for expressing fluorescent protein fusions. © 2021 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol: Fixing, permeabilizing, and staining mammalian cells in one step on the microscope
Information wars as a threat to the information security of Ukraine
Authors: Sopilko Iryna , Svintsytskyi Andrii , Krasovska Yevheniia , Padalka Andrii , Lyseiuk Andrii 
Published: November 2021

AbstractThe study gives definitions of information war (information warfare) and related terms, such as cyberwar and others, indicates the purposes, objects, subject matter, and subjects of the concepts under consideration. The author also considers the features of strategic information warfare conducted by the Russian Federation against Ukraine, the stages in the development of information war, and the classification of its types and methods. The approaches of scientists who studied certain aspects of information warfare were analyzed, based on their work relevant conclusions were drawn and the conceptual basis of the paper was formed. Independently, the definition and characteristics of the concept of cyber warfare inextricably linked with information warfare are given. Methods for solving the problems arising during the information war are introduced, ways of ensuring the information security of the state are provided. Information war in this study is considered as methods and means of presenting information to form the point of view needed by the organizers of information propaganda and the corresponding public opinion in a certain group of people. The author made an in‐depth analysis of the regulatory and legal instruments in force for counterfeiting information warfare and protecting the Ukrainian people from it, pointed out the deficiencies of such documents, and gave recommendations for their further advancement. Recommendations are given to improve the current information awareness among Ukrainians, the directions of the state policy in this field are suggested and ways to ensure the stability of the national information security system of Ukraine are provided.
Dense cold‐water coral garden of Paragorgia johnsoni suggests the importance of the Mid‐Atlantic Ridge for deep‐sea biodiversity
Authors: Morato Telmo , Dominguez‐Carrió Carlos , Mohn Christian , Ocaña Vicente Oscar , Ramos Manuela , Rodrigues Luís , Sampaio Íris , Taranto Gerald H. , Fauconnet Laurence , Tojeira Inês , Gonçalves Emanuel J. , Carreiro‐Silva Marina 
Published: November 2021

AbstractMid‐ocean ridges generate a myriad of physical oceanographic processes that favor the supply of food and nutrients to suspension‐ and filter‐feeding organisms, such as cold‐water corals and deep‐sea sponges. However, the pioneering work conducted along the Mid‐Atlantic Ridge failed to report the presence of large and dense living coral reefs, coral gardens, or sponge aggregations. Here, we describe the densest, near‐natural, and novel octocoral garden composed of large red and white colonies of Paragorgia johnsoni Gray, 1862 discovered at 545–595 m depth on the slopes of the Mid‐Atlantic Ridge, in the Azores region. This newly discovered octocoral garden is a good candidate for protection since it fits many of the FAO criteria that define what constitutes a Vulnerable Marine Ecosystem. The observations described here corroborate the existence of a close relationship between the octocoral structure and the ambient currents on ridge‐like topographies, providing new insights into the functioning of mid‐ocean ridges' ecosystems. The ubiquitous presence of biogenic and geological topographies associated with mid‐ocean ridges, which could act as climate refugia, suggests their global importance for deep‐sea biodiversity. A better understanding of the processes involved is, therefore, required. Our observations may inspire future deep‐sea research initiatives to narrow existing knowledge gaps of biophysical connections with benthic fauna at small spatial scales along mid‐ocean ridges.