bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valuation in health and ageing innovation practices
Authors: van Hees Susan , Greubel Carla , Moors Ellen , Peine Alexander 
Published: October 2021

AbstractIn the development and deployment of health and ageing innovations, underlying values such as privacy or quality of life are often seen as a relatively stable starting point, if considered at all. However, values are neither stable nor singular. This paper introduces a valuation framework to explore the co-constitution of values and technological innovations. A careful and ongoing reflection on values and valuation, in particular in innovation practices targeted at older people, is crucial when aiming to increase sustainable innovations. Therefore, we include a Social Sciences and Humanities (SSH) perspective to technological development and innovation, to understand better the construction and co-constitution of ageing-in-place technologies. This framework is developed following a review of literature on values and valuation in the broad field of SSH. The proposed valuation framework consists of three core elements: (a) value multiplicity, (b) value dynamism, and (c) valuation implications. To demonstrate potential applicability of the framework, we conducted a thought experiment on values and valuation practices related to the development and potential further deployment of a COVID-19 health app in the Netherlands. This experiment pays special attention to multiple values at stake and implications for older adults who age in place. We argue this valuation framework provokes reflection on dynamic and multiple values underlying technology use and non-use, and contributes to responsible health and ageing innovations.
Socrates in the fMRI Scanner: The Neurofoundations of Morality and the Challenge to Ethics
Authors: Rueda Jon 
Published: October 2021

AbstractThe neuroscience of ethics is allegedly having a double impact. First, it is transforming the view of human morality through the discovery of the neurobiological underpinnings that influence moral behavior. Second, some neuroscientific findings are radically challenging traditional views on normative ethics. Both claims have some truth but are also overstated. In this article, the author shows that they can be understood together, although with different caveats, under the label of “neurofoundationalism.” Whereas the neuroscientific picture of human morality is undoubtedly valuable if we avoid neuroessentialistic portraits, the empirical disruption of normative ethics seems less plausible. The neuroscience of morality, however, is providing relevant evidence that any empirically informed ethical theory needs to critically consider. Although neuroethics is not going to bridge the is–ought divide, it may establish certain facts that require us to rethink the way we achieve our ethical aspirations.
Well-Being After Severe Brain Injury: What Counts as Good Recovery?
Authors: Graham Mackenzie , Naci Lorina 
Published: October 2021

AbstractDisorders of consciousness (DOC) continue to profoundly challenge both families and medical professionals. Once a brain-injured patient has been stabilized, questions turn to the prospect of recovery. However, what “recovery” means in the context of patients with prolonged DOC is not always clear. Failure to recognize potential differences of interpretation—and the assumptions about the relationship between health and well-being that underlie these differences—can inhibit communication between surrogate decisionmakers and a patient’s clinical team, and make it difficult to establish the goals of care. The authors examine the relationship between health and well-being as it pertains to patients with prolonged DOC. They argue that changes in awareness or other function should not be equated to changes in well-being, in the absence of a clear understanding of the constituents of well-being for that particular patient. The authors further maintain that a comprehensive conception of recovery for patients with prolonged DOC should incorporate aspects of both experienced well-being and evaluative well-being.
Validation of a Short and Generic Qualitative Job Insecurity Scale	(QUAL-JIS)
Authors: Fischmann Gabriel , De Witte Hans , Sulea Coralia , Elst Tinne Vander , De Cuyper Nele , Iliescu Dragos 
Published: October 2021

Abstract. The Qualitative Job Insecurity Scale (QUAL-JIS) has been used in job insecurity (JI) research for the past 9 years, without formal validation. The goal of the current study was to test the scale’s psychometric properties. We checked the scale’s reliability, as well as its validity, investigating evidence based on the scale’s content, internal structure, and relations to other variables (convergent and discriminant, predictive and concurrent, as well as incremental predictive evidence). We additionally evaluated its cross-country and longitudinal invariance over three measurement times (6 months apart) in two countries (Romania and Belgium; NRO = 388, NBE = 1,992). We found evidence for the scale’s reliability and validity, QUAL-JIS showing partial scalar invariance across time and between the two countries. Interestingly, qualitative JI measured with QUAL-JIS explained additional variance in the employees’ need for recovery above and beyond another popular qualitative JI scale.
Constraining Low‐Altitude Lunar Dust Using the LADEE‐UVS Data
Authors: Sharma H. , Hedman M. M. , Wooden D. H. , Colaprete A. , Cook A. M. 
Published: October 2021

AbstractStudying lunar dust is vital to the exploration of the Moon and other airless planetary bodies. The Ultraviolet and Visible Spectrometer on board the Lunar Atmosphere and Dust Environment Explorer spacecraft conducted a series of Almost Limb activities to look for dust near the dawn terminator region. During these activities the instrument stared at a fixed point in the zodiacal background off the Moon's limb while the spacecraft moved in retrograde orbit from the sunlit to the unlit side of the Moon. The spectra obtained from these activities probe altitudes within a few kilometers of the Moon's surface, a region whose dust populations were not well constrained by previous remote‐sensing observations from orbiting spacecraft. Filtering these spectra to remove a varying instrumental signal enables constraints to be placed on potential signals from a dust atmosphere. These filtered spectra are compared with those predicted for dust atmospheres with various exponential scale heights and particle size distributions to yield upper limits on the dust number density for these potential populations. For a differential size distribution proportional to s−3 (where s is the particle size) and a scale height of 1 km, we obtain an upper limit on the number density of dust particles at the Moon's surface of 142 m−3.
Metafabrics for cooling under a scorching sun
Authors: Zhang Shuang 
Published: October 2021

AbstractEngineering the spectral response of composite materials in a broad range from ultraviolet to infrared can lead to a significant passive cooling functionality. This principle is applied to the design of a novel type of metafabric for cooling the human body under direct sunlight. Besides cooling effect, the metafabric features other merits including superior mechanical and wetting properties.
RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner
Authors: Cai Xianlei , Chen Yunhao , Man Da , Yang Beng , Feng Xiaode , Zhang Deguo , Chen Junru , Wu Jian 
Published: October 2021

AbstractThe function of the N6-methyladenosine (m6A) methyltransferase RNA-binding motif protein 15 (RBM15) in hepatocellular carcinoma (HCC) has not been thoroughly investigated. Here we determined the clinical value, biological functions, and potential mechanisms of RBM15 in HCC. Expression of RBM15 was identified using tissue microarrays and online databases. A risk-prediction model based on RBM15 was developed and validated. We determined the biological role of RBM15 on HCC cells in vitro and in vivo. RNA sequencing was used to screen candidate targets of RBM15. Subsequently, the m6A dot blot assay, methylated RNA immunoprecipitation qPCR, dual-luciferase reporter assays, RNA decay assay, and RNA immunoprecipitation qPCR were employed to explore the mechanisms of RBM15. Our study showed that RBM15 was highly expressed in HCC, and overexpression of RBM15 indicated a worse outcome. A new nomogram combining RBM15 with age and TNM stage was developed and validated to predict the outcome of HCC patients; our nomogram increased the prediction accuracy of the TNM system. Functionally, RBM15 facilitates the proliferation and invasiveness of HCC. RBM15-mediated m6A modification contributed to a post-transcriptional activation of YES proto-oncogene 1 (YES1) in an insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)-dependent manner. In addition, YES1 was confirmed as an oncogene in HCC cells by activating the mitogen-activated protein kinase (MAPK) pathway. In conclusion, RBM15-mediated m6A modification might facilitate the progression of HCC via the IGF2BP1–YES1–MAPK axis. RBM15 may be a promising biomarker in the outcome prediction of HCC.
The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus)
Authors: Francikowski Jacek , Potrzebska Marta , Szulińska Elżbieta , Tarnawska Monika , Radai Zoltan , Łozowski Bartosz , Baran Bartosz , Krzyżowski Michał 
Published: October 2021

AbstractTryptophan (TRP) is one of the essential amino acids in the animal body. Its exogenicity and low concentrations mean that it can be regarded as one of the key regulatory molecules at the cellular as well as physiological level. It has been shown to have a number of essential functions, such as in the production of other biologically active molecules. The main objective of this project was to investigate the effects of a high monosaccharide diet (HMD) on a hemimetabolic insect—house cricket (Acheta domesticus) and a mutant strain with impaired visual pigment synthesis (closely related to the tryptophan and kynurenine (KYN) metabolic pathway)—white eye. This study was aimed at determining the effects of glucose and fructose on cricket development and biochemical composition. A parallel goal was to compare the response of both cricket strains to HMD. ELISA assays indicated dysfunction of the TRP-KYN pathway in white strain insects and an elevated KYN/TRP ratio. Biochemical analyses demonstrated the effects of HMD mainly on fat and glycogen content. A decrease in food intake was also observed in the groups on HMD. However, no changes in imago body weight and water content were observed. The results of the study indicate a stronger response of the white strain to HMD compared to the wild-type strain. At the same time, a stronger detrimental effect of fructose than of glucose was apparent. Sex was found to be a modulating factor in the response to HMD.
Regression discontinuity of blood culture contamination rate after changing of disinfectants: retrospective observational study
Authors: Ota Koshi , Nishioka Daisuke , Ito Yuri , Hamada Emi , Mori Naomi , Nishii Tomonobu , Ota Kanna , Shibata Yuriko , Takasu Akira 
Published: October 2021

AbstractBlood cultures are indispensable for detecting life-threatening bacteremia. Little is known about associations between contamination rates and topical disinfectants for blood collection in adults. We sought to determine whether a change in topical disinfectants was associated with the rates of contaminated blood cultures in the emergency department of a single institution. This single-center, retrospective observational study of consecutive patients aged 20 years or older was conducted in the emergency department (ED) of a university hospital in Japan between August 1, 2018 and September 30, 2020. Pairs of blood samples were collected for aerobic and anaerobic culture from the patients in the ED. Physicians selected topical disinfectants according to their personal preference before September 1, 2019; alcohol/chlorhexidine gluconate (ACHX) was mandatory thereafter, unless the patient was allergic to alcohol. Regression discontinuity analysis was used to detect the effect of the mandatory usage of ACHX on rates of contaminated blood cultures. We collected 2141 blood culture samples from 1097 patients and found 164 (7.7%) potentially contaminated blood cultures. Among these, 445 (20.8%) were true bacteremia and 1532 (71.6%) were true negatives. Puncture site disinfection was performed with ACHX for 1345 (62.8%) cases and with povidone-iodine (PVI) for 767 (35.8%) cases. The regression discontinuity analysis showed that mandatory ACHX usage was significantly associated with lower rates of contaminated blood cultures by 9.6% (95% confidence interval (CI): 5.0%–14.2%, P < 0.001). Rates of contaminated blood cultures were significantly lower when ACHX was used as the topical disinfectant.
Population-level laterality in foraging finless porpoises
Authors: Amano Masao , Kawano Yudai , Kubo Taketo , Kuwahara Tsuyoshi , Kobayashi Hayao 
Published: October 2021

AbstractLaterality has been reported in many vertebrates, and asymmetrical cerebral hemisphere function has been hypothesized to cause a left-bias in social behavior and a right-bias in feeding behavior. In this paper, we provide the first report of behavioral laterality in free-ranging finless porpoises, which seems to support the aforementioned hypothesis. We observed the turning behavior of finless porpoises in Omura Bay, Japan, using land-based and unmanned aerial system observations. We found a strong tendency in finless porpoises to turn counterclockwise with their right side down when pursuing and catching fish at the surface of the water. Our results suggest that this population of finless porpoises shows consistent right-biased laterality. Right-biased laterality has been observed in various foraging cetaceans and is usually explained by the dominance of the right eye-left cerebral hemisphere in prey recognition; however, right-biased laterality in foraging cetaceans may have multiple causes.
Individual Hearing Outcomes in Cochlear Implant Users Influence Social Engagement and Listening Behavior in Everyday Life
Authors: O'Neill Erin R. , Basile John D. , Nelson Peggy 
Published: October 2021

Purpose:
The goal of this study was to assess the listening behavior and social engagement of cochlear implant (CI) users and normal-hearing (NH) adults in daily life and relate these actions to objective hearing outcomes.

Method:
Ecological momentary assessments (EMAs) collected using a smartphone app were used to probe patterns of listening behavior in CI users and age-matched NH adults to detect differences in social engagement and listening behavior in daily life. Participants completed very short surveys every 2 hr to provide snapshots of typical, everyday listening and socializing, as well as longer, reflective surveys at the end of the day to assess listening strategies and coping behavior. Speech perception testing, with accompanying ratings of task difficulty, was also performed in a lab setting to uncover possible correlations between objective and subjective listening behavior.

Results:
Comparisons between speech intelligibility testing and EMA responses showed poorer performing CI users spending more time at home and less time conversing with others than higher performing CI users and their NH peers. Perception of listening difficulty was also very different for CI users and NH listeners, with CI users reporting little difficulty despite poor speech perception performance. However, both CI users and NH listeners spent most of their time in listening environments they considered “not difficult.” CI users also reported using several compensatory listening strategies, such as visual cues, whereas NH listeners did not.

Conclusion:
Overall, the data indicate systematic differences between how individual CI users and NH adults navigate and manipulate listening and social environments in everyday life.
Neoplastic Elbow Diseases and Mimickers
Authors: Kaur Simranjeet , Lalam Radhesh , Cassar-Pullicino Victor , Tyrrell Prudencia , Singh Jaspreet 
Published: October 2021

AbstractTumors around the elbow are infrequent, and delayed diagnosis is a common theme because of the low incidence and lack of familiarity. However, just like any other site, the radiologic work-up of musculoskeletal tumors around the elbow remains the same, with plain films the first investigation in a patient with a suspected bone tumor and ultrasound the first modality to evaluate a soft tissue lump. The management of both bone and soft tissue tumors around the elbow is unique because of a large number of important structures in an anatomically confined space and little normal tissue to spare without severely compromising the joint's function. Many benign nonneoplastic entities can mimic bone and soft tissue tumors on imaging. It is important to keep the characteristic imaging appearance in mind while formulating a differential diagnosis to avoid an unnecessary additional work-up. This article reviews the most common benign and malignant bone and soft tissue tumors around the elbow, mimickers, imaging features, and current therapeutic concepts.
Keeping race at bay: familial DNA research, the ‘Turkish Community,’ and the pragmatics of multiple collectives in investigative practice
Authors: van Oorschot Irene , M’charek Amade 
Published: October 2021

AbstractIn this contribution, we analyze the recently adjudicated Milica van Doorn rape and murder case. In this case, committed in 1992, no suspect could be identified until investigatory actors employed familial DNA searching in 2017. Crucially, familial DNA typing raised the possibility of ethnic and racial stereotyping and profiling, particularly against the background of the first case in which familial DNA typing was used in the Netherlands: the Marianne Vaatstra case, which from the start had been marred by controversy about the ethnicity of the unknown perpetrator. In our analysis, we show how criminal justice actors managed this potential for racialization through strategically mobilizing and carefully managing multiple collectives. Drawing on the notions of multiplicity and non-coherence, we show we do not only empirically trace the situated ethics and pragmatics of familial DNA research in this specific case, but we also develop a theoretical argument on the multiple and non-coherent character of race itself and its attendant ethical, political, and methodological possibilities and obligations.
Legitimate suffering: a case of belonging and sickle cell trait in Brazil
Authors: Creary Melissa 
Published: October 2021

AbstractPatient activism organizations are formed around and seek legitimacy via both biological and biographical identities (Fassin, in: Theory Cult Soc 26(5):44–60, 2009). In the case of sickle cell disease (SCD) in Brazil, two different modes of suffering authenticate the lived experience—one is based on the disease state, the other is based on the ways in which racial inequalities and disadvantage contribute to its own suffering while also entangled with disease-based suffering. SCD is a rare genetic disorder that affects red blood cells and whose hallmark symptom is pain. This paper places an ethnographic focus on the failed mobilization of suffering by an organization leader in attempts to make claims for inclusion. The leader’s social and biological identities of mother, sickle cell trait carrier, middle class, andmulatadisrupted biosocial cohesion. This disruption reveals a hierarchy of suffering, where some indices of suffering are delegitimized. This hierarchy illuminates how exclusion and representation work within a patient organization whose membership embody both physical and social distress.
Simulation of absorption and scattering spectra of crystalline organic nanoparticles with the discrete dipole approximation: Effects of crystal shape, crystal size, and refractive index of the medium
Authors: Zutterman Freddy , Champagne Benoît 
Published: October 2021

The effect of the shape (habit) of crystalline organic nanoparticles on their absorption spectra is studied by simulations using the discrete dipole approximation, focusing, in particular, on the vibronic structure of the absorption bands in the spectra. Simulations predict a significant effect that, for sufficiently small particles, can be simply rationalized by the depolarization factor. The crystal size and the refractive index of the medium in which the nanoparticles are embedded are also found to have an effect on the absorption spectra. All factors mentioned are found to influence also the spectra of scattered light. These effects, already broadly documented for metallic nanoparticles, are here demonstrated theoretically for the first time for crystalline organic nanoparticles, providing novel insight into the optical response of such particles. The effects are expected to be displayed by all organic nanoparticles, as long as they have a well-defined crystal structure and are large enough for the optical properties to be understandable using a macroscopic dielectric tensor. The effects demonstrated here should be taken into account when rationalizing differences in absorption spectra of a substance in solution and in nanoparticle form, e.g., in deducing the type of intermolecular packing. The effects are much less pronounced for optically isotropic nanoparticles.
Topological barriers to defect nucleation generate large mechanical forces in an ordered fluid
Authors: Zappone Bruno , Bartolino Roberto 
Published: October 2021

SignificanceLiquid–solid mixtures, such as gels and clays, show a weak elastic response due to the compression of liquid molecules between solid surfaces. Liquid crystals exhibit a supramolecular structure and have the potential to generate strong forces in the fluid state. We devised a method to “harden” a liquid crystal using a surface geometry that approximates the contact between spherical particles. During compression, a large energy barrier prevents the release of elastic energy into dislocation defects so that the fluid film becomes trapped in a highly distorted state that generates exceptionally strong elastic forces. Because liquid crystals are optically anisotropic and respond to temperature and electric fields, mixtures with spherical colloids could produce an unusually strong and tunable optomechanical response.