bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It’s a change your life kind of program”: A Healing-Focused Camping Weekend for Urban Indigenous Families Living in Fredericton, New Brunswick
Authors: Hickey Jason , Powling Hayley , McKinney Patsy , Robbins Tristin , Carrier Nathan , Nash Abigail 
Published: October 2021

We present a community-driven research project designed to evaluate an innovative land-based healing initiative – a traditional camping weekend – for urban Indigenous families. The initiative was developed and implemented by Under One Sky Friendship Centre in Fredericton, NB, and involved a weekend-long celebration of culture and community. We gathered data from family members, staff, and stakeholders, and completed a thematic analysis and community review before synthesizing results into a narrative summary. Themes included Skitkəmikw (Land), Cəcahkw (Spirit), Skicinowihkw & Nekwtakotəmocik (Community & Family), and Sakələməlsowakən (Wellbeing). These connections are echoed throughout the article by quotes from participants that capture the essence of the experience. Our research helps to fill a knowledge gap in this area and supports the limited body of existing literature in demonstrating that community-led, land-based healing initiatives support Indigenous wellbeing in many ways that mainstream approaches cannot. Future work is needed to scale up land-based healing initiatives that provide community-led approaches to health promotion, and to examine the effects of ongoing participation on long-term health and wellness outcomes.
Le comité Witcihitisotan (entraide) par et pour les familles d’adolescents autochtones en ville
Authors: Blanchet-Cohen Natasha , di Mambro Giulietta , Petiquay Minic 
Published: October 2021

Cet article présente le processus et les apports du comitéWitcihitisotan(entraide, en atikamekw), mis en oeuvre par des parents d’adolescents dans un Centre d’amitié autochtone au Québec. À ce jour, les formes de soutien adéquates pour les familles d’adolescents autochtones demeurent sous-documentées, ce qui représente une lacune, considérant les ruptures et transitions particulières vécues par les jeunes autochtones en milieu urbain. L’analyse de la documentation des 14 mois d’activité du comité fait émerger trois formes de soutien interdépendantes et complémentaires : le comité permet de « se dire », pour échanger et partager des conseils entre parents ; de « se raconter », où l’écoute permet de cheminer vers la guérison ; et de « se projeter », afin de s’exprimer sur la façon de vivre sa culture en ville. Mettant en oeuvre une approche semblable à celle dustorytelling, le comité offre un lieu intergénérationnel de valorisation, de renforcement et d’autoguérison qui soutient l’apprentissage collectif des familles vers la réappropriation de compétences parentales et un mieux-être de la communauté. L’occasion de se rassembler dans un lieu émotionnellement et culturellement sécuritaire fait partie intégrante de l’approche décolonisante axée sur les forces. Cette étude de cas démontre l’importance de stimuler l’entraide entre pairs et de se moduler aux besoins du groupe. Ce type d’initiative permet de cheminer vers une amélioration des relations parent-jeune et une meilleure communication et connaissance de soi, qui seraient irréalisables par l’intermédiaire des approches apportées par des experts extérieurs, qui sont souvent préformatées et centrées sur les lacunes.
Digital Suffragists
Authors: Tessier Marie 
Published: October 2021

Why women's voices are outnumbered online and what we can do about it, by a New York Times comment moderator.
If you've read the comments posted by readers of online news sites, you may have noticed the absence of women's voices. Men are by far the most prolific commenters on politics and public affairs. When women do comment, they are often attacked or dismissed more than men are. In fact, the comment forums on news sites replicate conditions of the offline and social media worlds, where women are routinely interrupted, threatened, demeaned, and called wrong, unruly, disgusting, and out of place. In Digital Suffragists, Marie Tessier—a veteran journalist and a New York Times comment moderator for more than a decade—investigates why women's voices are outnumbered online and what we can do about it.
The suffragists of the early twentieth century were jailed for trying to vote. Can a twenty-first-century democracy be functional when half of the population is not fully represented in a primary form of political communication? Tessier shows that for online comments, it's a design problem: the linear blog comment formula was based on deeply gender-biased assumptions. Technologies designed with a broad range of end users in mind, she points out, are more successful and beneficial than those that reflect the designer's own habits of mind. Tessier outlines benchmarks for a more democratic media, all of which stem from one fundamental idea: media must adopt gender and racial representation as key performance indicators. Equal speaking time for women is a measure of democracy.
Elevated Plasma Fibrinogen and the Risk of Stroke: A Hospital Based Prospective Case-Control Study in Uyo, Nigeria
Authors: Ekwere Timothy A. , Ayoade Olufisayo G. , Ekeh Bertha C. , Dike Franklin O. 
Published: October 2021

Background: Stroke is one of the leading causes of morbidity and mortality globally. In recent time, there is increasing evidence that suggest that increased plasma fibrinogen is associated with increased risk of stroke with unfavourable clinical outcome.
Objectives: To determine the plasma fibrinogen levels in stroke patients and compare with healthy controls.
Study Design: The study design was Prospective case- control study.
Place and Duration of Study: The study was conducted in the department of Internal Medicine (Neurology Unit) and the department of Haematology between March to August, 2019.
Methodology: A case- control study consisting of 41 patients (21M: 19F) diagnosed with stroke in line with WHO definition and confirmed by CT-Scan of the brain were recruited consecutively into the study. 20 (10M: 10F) healthy age and gender matched consenting adults were used as controls. Plasma fibrinogen was determined for both the patients and controls using ELISA method. Also, socio-demographic and clinical data were collected using questionnaire designed for the study. The level of significance was set at P=.05.
Results: The mean plasma fibrinogen level of 458.0 ± 89.1 was significantly higher in the stroke patients compared to the controls 307.8 ± 61.5 (P<0.001). An increasing level of plasma fibrinogen was observed with increasing age in both the patients and controls. However, this increase was not statistically significant (P=0.98). Also, the plasma fibrinogen level was significantly higher in the female patients (501.21±83.96) than the males 420.59±77.02 (P=0.003).
Conclusion: Plasma fibrinogen was significantly higher in the stroke patients compared to the controls with female patients having a significantly higher levels than males. Also, the plasma fibrinogen levels appear to increase proportionally with increasing age.
Evaluation of OPTOS wide‐field fundus image projections for radiotherapy planning of uveal melanoma
Authors: Wulff Jörg , Koska Benjamin , Giese Michael , Bäumer Christian , Richter Ronald , Foerster Andreas , Bechrakis Nikolaos E. , Timmermann Beate 
Published: February 2025

AbstractPurposeTo investigate the relationship between the stereographic and azimuthal equidistant projection (AEP) of the human retina for radiotherapy planning with OPTOS optomap wide‐field fundus images (Optos, UK). Further, the geometric accuracy of an OPTOS fundus image is quantified.MethodsThe fundamental relationship between both projection modes was applied to transform images acquired with an OPTOS Silverstone camera to the azimuthal equidistant projection using MATLAB. Fundus images of four patients were used to quantitatively demonstrate the impact for neglecting the proper projection. For that purpose, a delineated contour for each patient was analyzed if created in a treatment planning system, which assumes AEP, and compared with an OPTOS image. Furthermore, an eye model with a novel 3D printed retina pattern was used to quantify the geometric accuracy for an OPTOS optomap image.ResultsThe difference between both projections was found substantial, leading to a change in delineated contours of more than 5 mm in the investigated cases and a change of delineated area of more than 40%. The geometric accuracy of OPTOS images of a customized eye model was found to be 0.2 mm on average, increasing to at most ∼0.5 mm at eye angles of 81°.ConclusionThe fundamental difference in the representation of the eye fundus needs to be accounted for in radiotherapy planning of uveal melanoma. The basic underlying relationship for transformation is known, but more research is required to quantify other aberrations. The novel use of 3D printed retina patterns with known dimensions is providing a flexible approach for further investigations.
Si‐CMOS Compatible Synthesis of Wafer‐Scale 1T‐CrTe2 with Step‐Like Magnetic Transition
Authors: Liu Jiwei , Wang Cong , Wang Yuwei , Xu Jianbin , Ji Wei , Xu Mingsheng , Yang Deren 
Published: February 2025

Abstract2D room‐temperature ferromagnet CrTe2 is a promising candidate material for spintronic applications. However, its large‐scale and cost‐effective synthesis remains a challenge. Here, the fine controllable synthesis of wafer‐scale 1T‐CrTe2 films is reported on a SiO2/Si substrate using plasma‐enhanced chemical vapor deposition at temperatures below 400 °C. Magnetic hysteresis measurements reveal that the synthesized 1T‐CrTe2 films exhibit perpendicular magnetic anisotropy along with distinct step‐like magnetic transitions. It is found that 1T‐CrTe2 is susceptible to oxygen adsorption even in ambient conditions. The theoretical calculations indicate that the oxidation of surface layers is crucial for the absence of out‐of‐plane easy axis in few‐layer CrTe2, while the interlayer antiferromagnetic coupling among the upper surface layers leads to the observed step‐like magnetic transitions. The study provides a Si‐CMOS compatible approach for the fabrication of magnetic 2D materials and highlights how unintentional adsorbents or dopants can significantly influence the magnetic behaviors of these materials.
Polarization Boost and Ferroelectricity Down to One Unit Cell in Layered Carpy‐Galy La2Ti2O7 Thin Films
Authors: Gradauskaite Elzbieta , Goossens Anouk S. , Li Xiaoyan , Iglesias Lucía , Gloter Alexandre , Meier Quintin N. , Bibes Manuel 
Published: February 2025

AbstractLayered perovskite‐based compounds offer a range of unconventional properties enabled by their naturally anisotropic structure. Among these, the Carpy‐Galy phases (AnBnO3n+2), characterized by (110)‐oriented perovskite planes interleaved with additional oxygen layers, stand out for robust in‐plane polarization. However, the challenges associated with the synthesis of ultrathin Carpy‐Galy films and understanding the impact of strain on their properties limit their integration into devices. Here, La2Ti2O7 (n = 4) films grown on substrates imposing tensile, compressive, or negligible epitaxial strains are investigated. Surprisingly, a 3% tensile strain from DyScO3 (100) substrates facilitates layer‐by‐layer growth mode, whereas compressive (LaAlO3‐Sr2TaAlO6 (110)) or negligible (SrTiO3 (110)) epitaxial strains require post‐deposition annealing to reach comparable crystallinity. Using density‐functional theory calculations, scanning probe microscopy, X‐ray diffraction, scanning transmission electron microscopy, and polarization switching experiments, it is confirmed that these films possess exceptional ferroelectric properties, including a polarization of 18 µCcm−2 – more than three times higher than previously reported – as well as persistence of ferroelectricity down to a single‐unit‐cell thickness. This study not only advances the understanding of Carpy‐Galy phases as epitaxial thin films but also lays a foundation for their integration into advanced ferroelectric device architectures.
Fabrication of Light‐Harvesting Au Nanoclusters System via Sequential Energy Transfer and the Usage as “On/Off” Switchable Logic Gates
Authors: Yang Mengqi , Sun Yuchen , Wang Xiaonan , Wang Jia , Liu Yongwei , Zhang Ailing , Shen Jinglin , Qi Wei 
Published: February 2025

AbstractLight‐harvesting is an indispensable process in photosynthesis, and researchers have been exploring various structural scaffolds to create artificial light‐harvesting systems. Herein, a light‐harvesting system (LHS) is constructed by AuNCs. First, ionic liquid 1‐Dodecyl‐3‐methylammonium bromide (C12mimBr) and Ba2+ are used to co‐assembly with 6‐aza‐2‐thiothymine (ATT) modified AuNCs to get ATT‐AuNCs/C12mimBr/Ba2+ (M‐AuNCs) with network superstructures and improved emission efficiency. This makes M‐AuNCs applicable for aqueous LHS. Furthermore, the green‐emitting network serves as energy donors, and red‐emitting positive dyes (rhodamine B) act as acceptors. An efficient energy transfer process occurs between them with an energy transfer efficiency of 94.1%. Significantly, sequential energy transfer can also be realized with the further addition of deep‐red emitting dye (sulforhodamine 101). Notably, the system can only be constructed by M‐AuNCs instead of mono‐dispersed ATT‐AuNCs. Based on this, a FRET‐triggered logic gate is established, in which C12mimBr and Ba2+ can be considered as energy switches to turn on/off the logic gate. Therefore, this work not only fabricates an AuNCs‐based LHS through sequential energy transfer, but also develops a FRET‐triggered logic gate, which has potential application in molecular recognition and information encryption.
Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism
Authors: Gagliardini Mathilde , Mechaussier Sabrina , Campos Pina Carolina , Morais Monica , Postal Olivier , Jean Philippe , Dupont Typhaine , Singh‐Estivalet Amrit , Udugampolage Shéhanie , Scandola Cyril , Verpy Elisabeth , Libé‐Philippot Baptiste , Inbar Talya C. , Schwenkgrub Joanna , Spinola Carla Maria Barbosa , Etournay Raphaël , El‐Amraoui Aziz , Bathellier Brice , Mallet Adeline , Delmaghani Sedigheh , Giraudet Fabrice , Petit Christine , Gourévitch Boris , Avan Paul , Michalski Nicolas 
Published: February 2025

AbstractAuditory neuropathies affect the spiral ganglion neurons of the auditory nerve or their synapses with the sensory hair cells, distorting the sound information transmitted from the ear to the brain. Deciphering the underlying pathophysiological mechanisms remains challenging owing to the diversity of spiral ganglion neuron subtypes and associated central auditory circuits. An auditory neuropathy mechanism is unraveled by investigating the origin of auditory hyperexcitability in a mouse model for hereditary congenital deafness. Otogl encodes the large Otogelin‐like protein, which is related to secreted epithelial mucins and is implicated in the mechanical stimulation of cochlear outer hair cells. Heterozygous Otogl+/− mutant mice display auditory hyperexcitability, highlighted by their susceptibility to audiogenic seizures induced by loud sounds. It is shown that Otogl is transiently expressed in a subpopulation of spiral ganglion neurons during cochlear development. Despite their apparently normal hearing, Otogl+/− mice display poor activation of the spiral ganglion neurons processing loud sounds and an elevation of the activation threshold of the middle the ear muscle reflex that attenuates loud sounds. The findings reveal how a neuropathy affecting spiral ganglion neurons specialized in loud sound processing and associated with the middle the ear muscle reflex can manifest itself as auditory hyperexcitability.
EIF4A3‐Mediated Biogenesis of CircFADS1 Promotes the Progression of Hepatocellular Carcinoma via Wnt/β‐Catenin Pathway
Authors: Tang Lei , Ji Yang , Ni Chuangye , Xu Zhenggang , Shen Yanjun , Lu Hao , Zhang Chuanyong , Yang Shikun 
Published: February 2025

AbstractMounting research indicates that circRNAs are pivotal elements in tumorigenesis and progression. Understanding the mechanisms by which circRNAs function in tumors is crucial for identifying undiscovered diagnostic and treatment targets. This research centers on unraveling the mechanisms by which the novel circRNA, circFADS1, influences hepatocellular carcinoma (HCC) progression. CircFADS1 shows elevated expression in HCC and is linked to unfavorable prognosis. Functionally, circFADS1 overexpression accelerates HCC progression through inducing HCC proliferation and inhibited apoptosis. Mechanistically, RNA‐seq analysis demonstrates its connection to the Wnt/β‐catenin pathway. Moreover, circFADS1 interacts with GSK3β and promotes its ubiquitination and degradation by recruiting the ubiquitin ligase RNF114 while EIF4A3 facilitates the biogenesis of circFADS1. Additionally, circFADS1 is closely linked to lenvatinib resistance. Overall, this study reveals that circFADS1 regulates GSK3β function, influencing the progression of hepatocellular carcinoma. The EIF4A3/circFADS1/GSK3β/β‐catenin axis is discovered to hold promise as a novel therapeutic target for hepatocellular carcinoma, while circFADS1 is also a significant factor in lenvatinib resistance.
Amidoxime‐Functionalized sp2‐Carbon‐Conjugated Covalent Organic Frameworks for Overall Photocatalytic Hydrogen Peroxide Production
Authors: Yu Zhiwu , Yu Fengtao , Xu Mei , Feng Shufan , Qiu Jianding , Hua Jianli 
Published: February 2025

AbstractCyano‐functionalized sp2‐carbon‐conjugated covalent organic frameworks (CN‐COFs) have been considered as promising candidates for artificial photosynthesis of hydrogen peroxide (H2O2). Nevertheless, the performance of CN‐COFs is inherently limited by constrained oxygen capture capacity, insufficient charge separation, and rapid carrier recombination. Herein, the study rationally reports a strategy for integrating amidoxime groups (AO) into a COF through one‐step cyano hydrolysis process to increase photocatalytic H2O2 production. Combined simulations and characterizations reveal that introducing AO groups enhances hydrophilicity, stabilizes adsorbed Oxygen (O2) via hydrogen bonding, accelerates the charge separation and transfer, as well as lowers the energy barrier for oxygen reduction reaction pathway, thus achieving an unmatched H2O2 production rate of 6024 µmol h−1 g−1. Importantly, the solar‐to‐chemical conversion (SCC) efficiency of PTTN‐AO reaches 0.61%, significantly surpassing that of natural plants (≈0.1%) and most COF‐based photocatalysts. The current findings are encouraging for the molecular design of polymers for green and efficient H2O2 production.
Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature
Authors: He Xiaoyan , Wang Runyuan , Cao Yan , Ding Yan , Chang Yan , Dong Haoru , Xie Rong , Zhong Guisheng , Yang Huiying , Li Jianfeng 
Published: February 2025

AbstractTargeted delivery of mRNA with lipid nanoparticles (LNPs) holds great potential for treating pulmonary diseases. However, the lack of rational design principles for efficient lung‐homing lipids hinders the prevalence of mRNA therapeutics in this organ. Herein, the combinatorial screening with structure‐function analysis is applied to rationalize the design strategy for nonpermanently charged lung‐targeted ionizable lipids. It is discovered that lipids carrying N‐methyl and secondary amine groups in the heads, and three tails originated from epoxyalkanes, exhibiting superior pulmonary selectivity and efficiency. Representative ionizable lipids with systematically variation in chemical structures are selected to study the well‐known but still puzzling “protein corona” adsorbed on the surface of LNPs. In addition to the commonly used corona‐biomarker vitronectin, other arginine‐glycine‐aspartic acid (RGD)‐rich proteins usually involved in collagen‐containing extracellular matrix, such as fibrinogen and fibronectin have also been identified to have a strong correlation with lung tropism. This work provides insight into the rational design of lung‐targeting ionizable lipids and reveals a previously unreported potential function of RGD‐rich proteins in the protein corona of lung‐homing LNPs.
Impact of a Multidisciplinary Approach to Polypharmacy Management in Community‐Dwelling Older Adults: Insights From a Specialized Outpatient Clinic
Authors: Roncal‐Belzunce Victoria , Gutiérrez‐Valencia Marta , Cedeño‐Veloz Bernardo Abel , San Miguel Ramón , Marín‐Epelde Itxaso , Galbete Arkaitz , Preciado Goldaracena Javier , Ezpeleta María Irache , Garaioa‐Aramburu Karmele , Martínez‐Velilla Nicolás 
Published: February 2025

ABSTRACTObjectivesThe increase in polypharmacy among older adults increases the risk of drug‐related problems, making multidisciplinary interventions essential. This study evaluated the impact of a multidisciplinary polypharmacy consultation on medication management and outcomes in older outpatients.MethodsThis prospective observational study at a Spanish teaching hospital involved geriatricians, clinical pharmacists, and nurses. Older adults (≥ 75 years) with polypharmacy underwent medication review at baseline and at 3 and 6 months. Data on medication use, adherence to Screening Tool of Older Person's Prescriptions (STOOP) criteria, and anticholinergic burden were analyzed.ResultsThe study included 104 older adults (mean age 86.2 years; 66% female). An average of 3.6 recommendations per participant was made (63.8% acceptance rate). Common drug‐related problems were adverse effects (20%), non‐adherence (18.1%), and incorrect dose/regimen (14.4%). Interventions led to an average reduction of 1.7 medications per patient, with 1.3 dosage or regimen changes and 1.1 new prescriptions. The mean number of medications decreased from 9.6 at baseline to 8.9 at 3 months (p < 0.001) and remained below baseline at 6 months. STOPP criteria violations per patient dropped from 1.2 to 1.0 (p = 0.036). Of the 126 medications flagged by STOPP criteria, 68.3% were addressed, 24.6% discontinued, mainly psychotropics, and 89.3% of these discontinuations were maintained. The anticholinergic burden decreased from 1.3 to 1.1 at 3 months (p = 0.036) and remained below baseline at 6 months.ConclusionsA multidisciplinary clinic effectively managed polypharmacy in older adults by reducing medication load and improving appropriateness per STOPP criteria, highlighting the importance of proactive medication management.Trial RegistrationClinicalTrials.gov: NCT05408598 (March 1, 2022)