bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPETITIVE EQUILIBRIA IN MATCHING MODELS WITH FINANCIAL CONSTRAINTS
Authors: Herings P. Jean‐Jacques , Zhou Yu 
Published: October 2021

AbstractWe consider a matching with contracts model in which buyers face financial constraints. In this model, a competitive equilibrium may fail to exist. We therefore propose the new notion of quantity‐constrained competitive equilibrium (QCCE). At a QCCE, buyers form expectations about the expected supply of trades. A buyer may expect that a trade is not to be supplied if the corresponding financial constraint is binding. We show the existence of QCCEs via a dynamic process that updates prices and quantity constraints, the equivalence between QCCE outcomes and stable outcomes, and some other properties of QCCEs like the lattice property.
Gene expression in Lucilia sericata (Diptera: Calliphoridae) larvae exposed to Pseudomonas aeruginosa and Acinetobacter baumannii identifies shared and microbe‐specific induction of immune genes
Authors: McKenna C. H. , Asgari D. , Crippen T. L. , Zheng L. , Sherman R. A. , Tomberlin J. K. , Meisel R. P. , Tarone A. M. 
Published: October 2021

AbstractAntibiotic resistance is a continuing challenge in medicine. There are various strategies for expanding antibiotic therapeutic repertoires, including the use of blow flies. Their larvae exhibit strong antibiotic and antibiofilm properties that alter microbiome communities. One species, Lucilia sericata, is used to treat problematic wounds due to its debridement capabilities and its excretions and secretions that kill some pathogenic bacteria. There is much to be learned about how L. sericata interacts with microbiomes at the molecular level. To address this deficiency, gene expression was assessed after feeding exposure (1 h or 4 h) to two clinically problematic pathogens: Pseudomonas aeruginosa and Acinetobacter baumannii. The results identified immunity‐related genes that were differentially expressed when exposed to these pathogens, as well as non‐immune genes possibly involved in gut responses to bacterial infection. There was a greater response to P. aeruginosa that increased over time, while few genes responded to A. baumannii exposure, and expression was not time‐dependent. The response to feeding on pathogens indicates a few common responses and features distinct to each pathogen, which is useful in improving the wound debridement therapy and helps to develop biomimetic alternatives.
Usefulness and yield of routine electroencephalogram: a retrospective study
Authors: Phamnguyen Thienan John , Szekely Alison , Swinburn Samuel , Babu Sangamithra , Boland‐Freitas Robert , Reutens David , Wolfe Nigel 
Published: October 2021

AbstractBackgroundThe electroencephalogram (EEG) is a common diagnostic tool used to investigate patients for various indications including seizure disorders.AimsTo investigate factors that predict the presence of epileptiform abnormalities on EEG and review the common indications for ordering an EEG.MethodsWe retrospectively reviewed all routine adult EEG performed in a hospital over a 6‐month period. Data collated included patient demographics, clinical indication for EEG, setting in which EEG was performed, activation procedures utilised, history of epilepsy, and whether the patient was on antiepileptic medication. Our primary objective was to evaluate the factors that were predictive of an EEG with epileptiform abnormalities.ResultsTwo hundred and thirty‐nine routine EEG were included with indications, including first seizure (25.9%), known epilepsy (25.1%), cognitive change (15.9%), syncope (15.0%), movement disorder (6.7%), psychogenic non‐epileptic events (5.4%), unresponsiveness/intensive care unit (4.6%) and psychiatric presentation (1.3%). Most (48.1%) EEG were normal; 8.9% of the EEG demonstrated epileptiform abnormalities. Using multivariate logistic regression, three variables proved significant in predicting an EEG with epileptiform abnormalities. Any seizure as an indication (first seizure or seizure in known epileptic), increasing patient age, and EEG conducted in an inpatient setting and within 48 h of seizure event were all statistically more likely to yield epileptiform abnormalities on EEG.ConclusionsOur findings suggest that careful selection of patients based on appropriate indications for EEG referral would likely improve the yield of an EEG. Depending on the indication, a normal EEG result can be of similar usefulness to an abnormal EEG demonstrating epileptiform abnormalities.
Potential predictors of quality of life in patients with venous leg ulcers: A cross‐sectional study in Taiwan
Authors: Lin Hsiao‐Ching , Fang Chien‐Liang , Hung Chang‐Chiao , Fan Jun‐Yu 
Published: October 2021

AbstractInternationally, the impact of venous leg ulcers (VLUs) on the quality of life is well recognised; however, in Taiwan, the focus is only on chronic wound management. This cross‐sectional correlational study conducted at the cardiovascular and plastic surgery clinics of a regional teaching hospital between August 2019 and June 2020 investigates venous clinical severity, pain, fatigue, depression, sleep quality, quality of life, and related factors among 167 patients with VLUs. The potential predictors of the quality of life in terms of activities were venous clinical severity (P < 0.001), pain (P = 0.004), and fatigue (P < 0.001) after adjusting for covariates. The potential predictors of the quality of life in terms of the psychological domain were marital status (single/divorced) (P = 0.016), marital status (widowed) (P = 0.027), venous clinical severity (P < 0.001), pain (P = 0.001), and fatigue (P = 0.002). The potential predictors of the quality of life with regard to symptoms were venous clinical severity (P < 0.001), pain (P < 0.001), fatigue (P = 0.001), and depression (P = 0.038). These potential predictors can serve as the basis of interventions for patients with VLUs, such as those related to nutrition or training in wound dressing.
Integrated LaB6/g‐C3N4 solar absorber for solving dye accumulation during solar steam generation
Authors: Yuan Baohua , Wei Lili , Yang Lixia , Bai Liangjiu , Yang Huawei , Wei Donglei , Wang Feng , Wang Wenxiang , Chen Hou 
Published: October 2021

AbstractSolar steam generation has attracted considerable interest due to its easy accessibility and sustainability. However, dye molecules were gradually concentrated on bulk water or the surface of solar absorbers during the disposal of dye wastewater. Herein, LaB6/g‐C3N4 composites were immobilized on porous cotton cloth, served as a solar absorber resistant to dye clogging. The optimal solar absorber possessed solar harvesting of 92.3% and showed great application potential in the field of the treatment of dye wastewater. This study presented a new approach for the treatment of dye wastewater.
Toward revealing atomic deformation mechanics in lithium disilicate and β‐quartz containing glass‐ceramics
Authors: Deng Binghui , Harris Jason T. , Smith Charlene M. , Luo Jian 
Published: October 2021

AbstractThe mechanics of glass‐ceramics subjected to sharp contact or other loading conditions remain elusive, even after being commercialized in many industrial applications. We present work herein to reveal atomic details of such deformations that are otherwise extremely difficult to probe experimentally for a lithium disilicate (LS2) and β‐quartz containing glass‐ceramics via molecular dynamics simulations. Specifically, the materials are comprised of LS2 and β‐quartz nanocrystals in a residual glass matrix. Regardless of the deformation mechanism, whether it be nanoindentation or crack propagation for samples with pre‐existing flaws, we observe that the LS2 nanocrystal itself undergoes substantial deformation, either by activating dislocations, forming an amorphization zone, or by initiating microcracks at glass‐crystal interfaces or weak crystallographic planes. In contrast, the β‐quartz nanocrystal is not easily deformed and remains almost intact with minimal plastic deformation, thereby forcing shear flow and crack propagation pathways to predominately occur in the residual glass and/or at interfaces. The dramatic difference between the crystalline phases also manifests itself in the deformation mode of interfaces under pure shear loading, in which shear bands preferably occur at the LS2‐glass interfaces, while cavities form at the β‐quartz‐glass interfaces. These observations significantly advance our understanding of glass‐ceramics and pave ways to exploit the understanding for more applications.
Higher education students' experiences and opinion about distance learning during the Covid‐19 pandemic
Authors: Stevanović Aleksandra , Božić Radoslav , Radović Slaviša 
Published: October 2021

AbstractBackgroundThe Covid‐19 pandemic has created significant challenges for the global higher education community. Understanding of students' perception has important implications for the quality of the learning process, as it affects students' engagement in learning, helps educators rethink the principles of the learning design and further improve the developed programs.ObjectivesUnderstanding of how rapid and necessary changes of learning caused by the pandemic are related to students' intrinsic motivation and awareness.MethodsThere were 832 participants in this study. Quantitative and qualitative research methods employing relevant statistical techniques were used to research students' opinions regarding the distance learning process.Results and ConclusionsOur analysis showed that first‐year students were significantly less motivated during the learning process than older students, they saw distance learning as less valuable and less interesting than the others. Our research found several positive consequences of the pandemic: working according to students' own schedule in a relaxed environment, looking at the lecture again if necessary, feeling free to ask questions and communicate with teachers and saving travel time.ImplicationsTeachers should have more understanding for the first‐year students who are threatened when it comes to developing motivation to learn and help them cope with learning anxieties, encourage their self‐belief and give them extra support during the learning process.
Aucubin prevents steroid‐induced osteoblast apoptosis by enhancing autophagy via AMPK activation
Authors: Yue Chen , Jin Hongting , Zhang Xue , Li Wuyin , Wang Deli , Tong Peijian , Liu Youwen , Tan Zhen 
Published: October 2021

AbstractSteroid‐induced osteoblast apoptosis is a crucial pathological process in steroid‐induced osteonecrosis of the femoral head (SONFH). Autophagy can resist apoptosis and AMPK plays an important role in autophagy regulation. Aucubin from the small tree Eucommia ulmoides Oliv., which has a long history of use in orthopaedics and traumatology in Asian medicine, can promote bone formation, but whether it can slow or prevent steroid‐osteoblast apoptosis is unclear. Therefore, we investigated the pathogenesis of SONFH and how the osteoblast responds to aucubin under the dexamethasone stimulation. In human femoral head osteonecrosis specimens, we found that the autophage and apoptosis level were increased, and the AMPK signalling was crucial to autophagy. We observed that aucubin could prevent dexamethasone‐induced apoptosis in osteoblasts by enhancing the level of autophagy. Further, we confirmed that the regulatory effect of aucubin on autophagy and apoptosis was achieved by activating AMPK signalling. We have demonstrated a mechanism of disease progression and shown that aucubin could enhance autophagy through AMPK signalling to prevent osteoblast apoptosis. These findings provide a basis for the further investigation of the potential therapeutic role of aucubin in the SONFH.
Development and characterization of five novel cell lines from snubnose pompano, Trachinotus blochii (Lacepede, 1801), and their application in gene expression and virological studies
Authors: Abdul Nafeez Ahmed , Seepoo Abdul Majeed , Gani Taju , Sugumar Vimal , Selvam Suryakodi , Allahbagash Badhusha , Abdul kuthoos Abdul Nazar , Palsamy Ramesh Kumar , Kishore M. Paknikar , M. Rajwade Jyutika , Azeez Sait Sahul Hameed 
Published: October 2021

AbstractFive novel permanent cell lines have been established from gill, heart, kidney, eye and fin of snubnose pompano, Trachinotus blochii. They were designated as snubnose pompano gill (SPG), snubnose pompano heart (SPH), snubnose pompano kidney (SPK), snubnose pompano eye (SPE) and snubnose pompano fin (SPF), respectively. All these cell lines were characterized and cryopreserved successfully at different passage levels. Cell lines were passaged every alternate day; SPG, SPH, SPK, SPE and SPF cell lines attained passage levels of 68, 74, 82, 79 and 106, respectively, since the initiation of their development in 2019. The cell lines grew well in Leibovitz's 15 medium containing 15% foetal bovine serum at 28°C. Immunophenotyping of the cell lines revealed the presence of fibronectin and pancytokeratin. No mycoplasma contamination was found. The transfection study revealed the gene expression efficiency of these cell lines by expressing the green fluorescent protein (GFP). The authentication on origin of cell lines from T. blochii was confirmed by amplification of species‐specific mitochondrial cytochrome oxidase I gene. The results showed the susceptibility of these cell lines to fish nodavirus (FNV) and tilapia lake virus (TiLV) and resistance to cyprinid herpesvirus 2 (CyHV‐2). The FNV infection in the cell lines was confirmed by RT‐PCR, Western blot, ELISA and immunocytochemistry, while TiLV infection was confirmed by RT‐PCR assay. These results revealed that these cell lines are suitable for virological and foreign gene expression studies.
Using Theories of Posttraumatic Stress to Inform Perinatal Care Clinician Responses to Trauma Reactions
Authors: Granner Josephine R. , Seng Julia S. 
Published: October 2021

AbstractUnderstanding of the importance of addressing trauma in health care is increasing rapidly. Health care providers may be actively seeking ways to address trauma sequelae affecting their patients with a trauma‐informed continuum of care. Such a continuum includes a universal approach, targeted interventions (ie, practices and programs), and specialist treatment for posttraumatic stress disorder (PTSD), as well as responses to historic and intergenerational trauma. Client presentations and their needs are highly individualized. Therefore, an understanding of prominent theories of what causes PTSD may assist perinatal care professionals in adapting their practice to be trauma‐informed and trauma‐specific. The purpose of this article is to review 4 theories of PTSD relevant to perinatal practice and present an evidence‐based practice framework that encourages collaborative choices consistent with client values and preferences. A brief summary of current evidence‐based PTSD treatment guidelines is presented.
A Student‐Driven Community Engagement Model for School Nutrition Education Programs
Authors: Cory Megan , Johnston Bryan , Nelson David 
Published: October 2021

ABSTRACTBACKGROUNDParental engagement in nutrition education programs often focuses on direct communication with parents. While this is an important component for the success of nutrition education, the role that students can play in connecting the program to their home is often overlooked.METHODSFeedback from students participating in a nutrition education program was used to develop an intervention that allowed students to take snacks they prepared in class home to their families. Change in parental awareness and family communication about the program was assessed in response to this intervention. A total of 257 third‐grade students and 80 of their parents completed surveys to assess communication and interest in learning more about nutrition through the program.RESULTSA significant increase in family awareness and communication about the nutrition program was reported in response to the intervention that gave the students the ability to share food they made in class with their families.CONCLUSIONSCommunity engagement for school nutrition education programs is effective in stimulating family conversation about nutrition when methods are cognizant of students potential and motivation for driving these conversations. Our model for student‐centered community engagement can be used by nutrition education programs to increase parental engagement.
First report of root rot disease on Solanum lycopersicum L. caused by Fusarium vanettenii in India
Authors: Debbarma Rubin , Kamil Deeba , Maya Bashyal Bishnu , Choudhary Shiv Pratap , Thokla Prameeladevi 
Published: October 2021

AbstractTomato (Solanum lycopersicum L.) is one of the most important and widely grown vegetable crops throughout India. Typical symptoms of root rot were observed in an experimental field of ICAR‐Indian Agricultural Research Institute, New Delhi (India), during July‐August 2019 with an incidence of 25%. Based on morphological characteristics and multi‐locus sequence‐based analyses, the pathogen was identified as Fusarium vanettenii. The pathogenicity test was also done to prove Koch's postulate. To the best of our knowledge, this is the first report of F. vanettenii causing root rot disease on tomato in India.
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease
Authors: Chen Chongyang , Yang Chao , Wang Jing , Huang Xi , Yu Haitao , Li Shangming , Li Shupeng , Zhang Zaijun , Liu Jianjun , Yang Xifei , Liu Gong‐Ping 
Published: October 2021

AbstractWhile melatonin is known to have protective effects in mitochondria‐related diseases, aging, and neurodegenerative disorders, there is poor understanding of the effects of melatonin treatment on mitophagy in Alzheimer's disease (AD). We used proteomic analysis to investigate the effects and underlying molecular mechanisms of oral melatonin treatment on mitophagy in the hippocampus of 4‐month‐old wild‐type mice versus age‐matched 5 × FAD mice, an animal model of AD. 5 × FAD mice showed disordered mitophagy and mitochondrial dysfunction as revealed by increased mtDNA, mitochondrial marker proteins and MDA production, decreased electron transport chain proteins and ATP levels, and co‐localization of Lamp1 and Tomm20. Melatonin treatment reversed the abnormal expression of proteins in the signaling pathway of lysosomes, pathologic phagocytosis of microglia, and mitochondrial energy metabolism. Moreover, melatonin restored mitophagy by improving mitophagosome–lysosome fusion via Mcoln1, and thus, ameliorated mitochondrial functions, attenuated Aβ pathology, and improved cognition. Concurrent treatment with chloroquine and melatonin blocked the positive behavioral and biochemical effects of administration with melatonin alone. Taken in concert, these results suggest that melatonin reduces AD‐related deficits in mitophagy such that the drug should be considered as a therapeutic candidate for the treatment of AD.
Adjunctive Er:YAG laser in non‐surgical periodontal therapy of patients with inadequately controlled type 2 diabetes mellitus: A split‐mouth randomized controlled study
Authors: Feng Chenchen , Ding Yi , Tang Liqin , Gui Yong , Shen Xiaoyun , He Linlin , Lu Xinyan , Leung Wai Keung 
Published: October 2021

AbstractBackground and ObjectiveLimited studies are available comparing the outcomes of non‐surgical periodontal therapy (NSPT) with or without adjunctive Er:YAG laser (ERL) in patients with type 2 diabetes mellitus (T2DM). This study evaluated the effects of ERL adjunctive NSPT on single‐rooted teeth of inadequately controlled T2DM patients with periodontitis.MethodsTwenty‐two inadequately controlled T2DM participants with periodontitis were recruited. Adopting a double‐blinded split‐mouth design and under block randomization, we investigated the effects of ERL in calculus removal then degranulation mode, or a sham treatment, adjunct NSPT, which included two visits of full‐mouth root surface debridement delivered within 4–10 days, to test or control single‐rooted teeth (Wuxi Stomatology Hospital, trial 2017‐016). We followed periodontal parameters (plaque %, bleeding on probing [BOP] %, probing pocket depth [PPD], probing attachment level [PAL]) and selected systemic parameters (fasting plasma glucose [FPG], glycosylated hemoglobin [HbA1c%], high sensitivity C‐reactive protein) at baseline, one, three, and six months after periodontal treatment.ResultsThe study was completed as planned. Periodontal parameters, FPG and HbA1c% of the 22 participants appeared significantly improved at six months (p < 0.001). The 44 ERL treated, compared to 44 sham treated single‐rooted teeth exhibited significant improvement in BOP, mean PPD, and mean PAL at various postoperative follow‐up time points (effect size ≥0.44; p < 0.001). No adverse event was reported.ConclusionPeriodontal treatment outcomes in the T2DM patients with inadequate glycemic control were better in the single‐rooted teeth received ERL adjunct NSPT. Further studies are warranted to confirm the observations reported in this short‐term clinical study.
Pharmacokinetics and milk excretion pattern of eprinomectin at different dose rates in dairy cattle
Authors: Ballent Mariana , Canton Candela , Dominguez Paula , Mate Laura , Ceballos Laura , Lanusse Carlos , Lifschitz Adrian 
Published: October 2021

AbstractThis study aimed at determining the plasma disposition kinetics of eprinomectin (EPM) and EPM excretion pattern through milk after topical administration to dairy cattle at the recommended dose of 0.5 mg/kg and at 1 and 1.5 mg/kg. A high variability in the plasma concentration profiles was observed among animals, particularly in the Cmax values, with a coefficient of variation between 39 and 53%. The Cmax and AUC values were significantly affected by the dose administered at 1.5 mg/kg. However, such differences did not seem to follow a linear pattern among treatments. These parameters did not differ among dose rates after dose normalization; nevertheless, the simulation of a linear kinetic disposition showed a mean plasma AUC value of 254 ng.d/ml instead of the observed value of 165 ng.d/ml. EPM concentration profiles in milk were significantly lower than those measured in plasma. The Cmax and AUC milk‐to‐plasma ratios ranged from 0.14 to 0.26 and 0.16 to 0.21, respectively (p>0.05). The low milk‐to‐plasma ratio of EPM accounted for a low percentage of the fraction of the administered dose excreted through milk, being significantly higher at a dose rate of 0.5 mg/kg (0.07%) of EPM than at 1.5 mg/kg (0.04%) (p<0.05). The topical administration of EPM to lactating dairy cows at higher doses than that recommended for gastrointestinal nematodes showed a milk excretion pattern with a zero milk withdrawal period. In conclusion, the administration of topical EPM formulation at 1 or 1.5 mg/kg may be a valuable tool to be used in regional strategic deworming programs aimed to control ectoparasite infections in dairy production systems.