bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Established Pyroptosis-participant Genes Signature for Predicting the Prognosis of Idiopathic Pulmonary Fibrosis
Authors: He Qian , Cao Yi , Zhao Yue , Shen Yi , Xu Xiong , Zhang Qiu-Di 
Published: December 2021

Abstract
Idiopathic pulmonary fibrosis (IPF), caused by a strange reason and characterized by a bad clinical prognosis, is an advanced, long-time, and irreversible interstitial lung disease (ILD). In recent years, it has been confirmed that a pyroptosis is a phlogistic form of programmed cellular demise. At the same time, the expression of the pyroptosis-participant gene (PPG) in IPF and their pertinence behind prognosis remains indistinct. In this research, we identified 17 pyroptosis regulators that were distinguishingly expressed entre IPF and controls. The ground on these distinguishingly expressed genes (DEGs), entire IPF conditions could be uncoupled into two subtypes. The prognostic significance of respective PPG for surviving was assessed to find a polygenes signature doing with a Gene Expression Omnibus (GEO) pack (GSE28042). Via putting into use the least absolute shrinkage and selection operator (LASSO) Cox regression approach, a 6-gene signature was structured and ranged entire IPF sicks in GSE28042 into a shallow-threat or high-threat group. IPF sicks in the shallow-threat group revealed meaningfully upper survival chances than those in the high-threat group (pvalue < 0.001). Exploiting the mid threat-score from GSE28042, IPF sicks from another GEO cohort(GSE70866-GPL17077) were separated into two threat subgroups, and the shallow-threat set had augmented overall survival (OS) time ( P = 0.0018). United the clinical characteristics, the threat-score was a sole element for forecasting the overall survival of IPF sicks. Function enrichment analyses bespoke that modification of morphology or physiology of other organisms, killing of cellular of other organisms, and disruption of cellular of other organisms biological processes were increased in the high-threat group. GSEA(Gene Set Enrichment Analysis) showed that cancer- and autoimmune disease-participant “KEGG” gene sets were highly enriched in the high−threat phenotype. In general, PPGs play a crucial role in IPF and can be done to forecast the prognosis of IPFs, and our consequences suggest that the high-threat group of IPF may be linked with the response of other organisms and autoimmunity as well.
Swift Reduction of Nitroaromatics By Gold Nanoparticles Anchored On Steam-Activated Carbon Black Via Simple Preparation
Authors: Fu Yukui , Lai Cui , Chen Wenjing , Yi Huan , Liu Xigui , Huo Xiuqin , Cao Weicheng , Zeng Zhuotong , Qin Lei 
Published: December 2021

Abstract
Gold (Au) nanoparticles supported on certain platforms display highly efficient activity on nitroaromatics reduction. In this study, steam-activated carbon black (SCB) was used as a platform to fabricate Au/SCB catalysts via a green and simple method for 4-nitrophenol (4-NP) reduction. The obtained Au/SCB catalysts exhibit efficient catalytic performance in reduction of 4-NP (rate constant kapp = 2.1925 min-1). The effects of SCB activated under different steam temperature, Au loading amount, pH and reaction temperature were studied. The structural advantages of SCB as a platform were analyzed by various characterizations. Especially, the result of N2 adsorption-desorption method showed that steam activating process could bring higher surface area (from 185.9689 m²/g to 249.0053 m²/g), larger pore volume (from 0.073268 cm³/g to 0.165246 cm³/g) and more micropore for SCB when compared with initial CB, demonstrating the suitable of SCB for Au NPs anchoring, thus promoting the catalytic activity. This work contributes to the fabrication of other supported metal nanoparticle catalysts for preparing different functional nanocomposites for different applications.
Dimethyl Phthalate Induces Blood Immunotoxicity Through Oxidative Damage And Caspase-Dependent Apoptosis
Authors: Chi Zhenxing , Lin Hongwei , Meng Xuanlin , Zhou Jieqiong , Xiang Li , Cao Guodong , Wu Pengfei , Zhao Xingchen , Cai Zongwei 
Published: December 2021

Abstract
Dimethyl phthalate (DMP), a low molecular weight phthalate ester, is present in ectoparasiticides, plastics, and insect repellants, has been linked to neurotoxic, reproductive, and endocrine disruptive responses. However, its blood immunotoxic effects and mechanism remain poorly understood. In this study, rats were exposed to graded concentrations of DMP through intragastric administration to assess the blood immunotoxic effects using a combination assay of biomarker, cytometry, and transcriptomics. DMP treatment altered the redox status of rats, causing that oxidative damage. Significantly decreased blood cell counts and disordered antibody and cytokine secretion were observed, suggesting the suppressed immune defense and destructed inflammatory regulation. Flow cytometry showed for lymphocytes, especially CD3+CD4+ T cells, apoptosis/necrosis occurred positively related to DMP exposure level. Transcriptomics revealed responses that were in line with oxidative damage effects. Overexpression of the Bcl-2 family genes and activation of the Fas/FasL pathway trigger downstream caspase cascade, causing reactive oxygen species signaling mediated apoptosis/necrosis. This is the first report on immunotoxic effects of low molecular weight phthalate esters.
Efficacy And Safety of Wound Infiltration Modalities For Postoperative Pain Management After Cesarean Section: A Systematic Review, Meta-Analysis, And Trial Sequential Analysis Protocol
Authors: Abate Semagn Mekonnen , Mantefardo Bahiru , Nega Solomon , Basu Bivash , Taddesse Moges 
Published: December 2021

Abstract
Background: Inadequately managed postoperative pain after cesarean section has a number of consequences to the mother in the postoperative period. Different postoperative pain management modalities have been practiced after cesarean section over the years. The opioid based analgesics and land mark techniques have undesirable consequences, regional analgesia technique with ultrasound requires resource and expertise while different wound infiltration techniques are new techniques with minimal side effect and easy to administer. However, the effectiveness of each technique is uncertain and needs further investigation.Objective: This systematic review will provide the most effective wound infiltration technique to prevent undesirable adverse effects of opioids and untreated painMethod: A comprehensive search will be conducted in PubMed/Medline, Cochrane, Science direct, CINHAL, and LILACS without date and language restriction. All randomized trials comparing the efficacy of wound infiltration for postoperative pain management after cesarean section will be included. The data will be extracted with two independent authors in a customized format. The methodological quality of included studies will be evaluated using the Cochrane risk of bias tool. The overall quality of the evidence will be determined by GRADEpro software. Trial Sequential Analysis will be conducted to investigate the necessity of further trials.Discussion: The incidence of postoperative acute as well as chronic pain is very high which has a tremendous impact on the mother, family, healthcare providers, and healthcare delivery. It is a basic human right to provide postoperative pain management to every patient that is feasible to everyone in terms of resources, technique, cost, and minimal adverse events profileRegistration: This systematic review protocol was registered in Prospero (CRD42021270710) on September 5, 2021
Dominant Controls of Cold-Season Precipitation Variability Over the High Mountains of Asia
Authors: Ashfaq Moetasim , Mehmood Shahid , Kapnick Sarah , Ghosh Subimal , Abid Muhammad Adnan , Kucharski Fred , Batibeniz Fulden , Saha Anamitra , Evans Katherine , Hsu Huang-Hsiung 
Published: December 2021

Abstract
A robust understanding of the sub-seasonal cold season (November–March) precipitation variability over the High Mountains of Asia (HMA) is currently lacking. Here, we identify dynamic and thermodynamic pathways through which natural modes of climate variability establish their teleconnections over the HMA. First, we identify evaporative sources that contribute to the cold season precipitation over the HMA and surroundings areas. The predominant moisture contribution comes from the mid-latitude regions including Mediterranean/Caspian Seas and Mediterranean land. Second, we establish that several tropical and extratropical forcing display a sub-seasonally fluctuating influence on the cold season precipitation distribution over the region, and given that many of them varyingly interact with each other, their impacts cannot be explained exclusively or at seasonal timescales. Lastly, a single set of evaporative sources cannot always be identified as the only determinant in propagating a remote teleconnection, because nature of moisture anomalies and its sources depend on the pattern of sub-seasonally varying dynamical forcing in the atmosphere.
Direct growth of copper(I) oxide nanocubes on graphitic carbon nitrides enhancing aqueous carbon dioxide photoreduction
Authors: Song Hyunjoon , Choi Byeonghoon , Lim Chan Kyu , Kim Minjun , Park Bumjin , Park Won-Woo , Kwon Oh-Hoon , Lee Hee-Seung 
Published: December 2021

Abstract
Semiconductor hybrid structures containing multiple components have been considered an ideal photocatalyst design to generate long-lived charge-separated states. Particularly for the reactions requiring high activation energies, such as a CO2 reduction reaction (CO2RR), the reaction activity is highly susceptible to the catalyst component and morphology. In this study, we selected g-C3N4 and Cu2O as photocatalytic components having bandgaps suitable for CO2RR. Then, we tried to form good electric junctions between two domains by direct growth of Cu on g-C3N4 using a polyol process. The resulting g-C3N4/Cu2O hybrid was employed as photocatalysts in an aqueous medium without hole acceptors. The catalyst exhibited a noticeable activity (5.4 mmol gcat-1h-1) and quantum yield (3.7%) with a nearly quantitative selectivity for CH4 production, superior to any other photocatalysts for CO2RR. The strong coordination of g-C3N4 to the Cu2O surface could form a conductive junction and induce effective electron transfer enforcing the Z-scheme process for CO2RR in high activity and selectivity. This result ensured the importance of junctions and interfaces in the hybrid catalyst structure to exhibit excellent photocatalytic CO2RR performances.
Identification and Evaluation of Circulating Small Extracellular Vesicle Micrornas as Diagnostic Biomarkers for Patients with Indeterminate Pulmonary Nodules
Authors: Zheng Di , Zhu Yuming , Zhang Jiyang , Zhang Wei , Wang Huizhen , Chen Hao , Wu Chunyan , Ni Jian , Xu Xiaoya , Nian Baoning , Chen Sheng , Wang Beibei , Li Xiaofang , Zhang Yanan , Zhang Jiatao , Zhong Wenzhao , Xiong Lei , Li Fugen , Zhang Dadong , Xu Jianfang , Jiang Gening 
Published: December 2021

Abstract
Background: The identification of indeterminate pulmonary nodules (IPNs) following a low-dose computed tomography is a major challenge for early diagnosis of lung cancer. The inadequate assessment of IPNs’ malignancy risk results in a large number of unnecessary surgeries or an increased risk of cancer metastases. However, limited studies on non-invasive diagnosis of IPNs have been reported.Methods: In this study, we identified and evaluated the diagnostic value of circulating sEV miRNAs in patients with IPNs that had been newly detected using LDCT scanning and were scheduled for surgery. Out of 459 recruited patients, 109 eligible patients with IPNs were enrolled in the training cohort (n = 47) and the test cohort (n = 62). An external cohort (n=99) was used for validation. MiRNAs were extracted from plasma sEVs, and assessed using Small RNA sequencing. 490 lung adenocarcinoma samples and follow-up data were used to investigate the role of miRNAs in overall survival.Results: A circulating sEV miRNA (CirsEV-miR) model was constructed from five differentially expressed miRNAs (DEMs), showing 0.920 AUC in the training cohort (n = 47), and further identified in the test cohort (n = 62) and in an external validation cohort (n = 99). Among five DEMs of the CirsEV-miR model, miR-101-3p and miR-150-5p were significantly associated with better overall survival (p = 0.0001 and p = 0.0069). The CirsEV-miR scores were calculated, which significantly correlated with IPNs diameters (p < 0.05), and were able to discriminate between benign and malignant PNs (diameter ≤ 1 cm). The expression patterns of sEV miRNAs in the benign, adenocarcinoma in situ/minimally invasive adenocarcinoma, and invasive adenocarcinoma subgroups were found to gradually change with the increase in aggressiveness for the first time. Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients.Conclusions: Our results indicate that the CirsEV-miR model could help distinguish between benign and malignant PNs, providing insights into the feasibility of circulating sEV miRNAs in diagnostic biomarker development.Trial registration: Chinese Clinical Trials, ChiCTR1800019877. Registered 05 December 2018, https://www.chictr.org.cn/showproj.aspx?proj=31346.
Detection Of Change In Land Cover In Jabalpur District From 1991-2021 Using Remote Sensing
Authors: Lakhera Shubham , Rahi Dal Chand 
Published: December 2021

Abstract
Land use/ land cover is an important component in understanding the interactions of human activities with the environment and thus it is necessary to monitor and detect the changes to maintain a sustainable environment. In this paper, an attempt has been made to study the changes in land use and land cover of Jabalpur district in the last 4 decades from 1991 to 2021 classifying majorly in Forest (Medium to Dense), Trees, Waterbody, Settlements & Agricultural fields. The study was carried out through the Remote Sensing and GIS approach using High-resolution Imagery from Google Earth, and LANDSAT 8, 7, 5 imagery of 2021, 2011, 2001, 1991 respectively. The land use/land cover classification was performed based on the Supervised Classification approach available in ArcGIS. GIS software is used to prepare the thematic maps and ground truth observations were also performed to check the accuracy of the classification. The present study has brought out that the Tree cover has been decreased from 12.97–5.40% during 1991-2021 showing a considerable decrease in Forest area as well. The settlement area increased from 4.26% in 1991 to 12.46% in 2021. The areas under natural streams, have shown no significant change and can be considered as a positive sign for sustainable development.
Configuration Design and Motion Performance Analysis of a New Wheeled Rolling Robot
Authors: Bian Hui , Zhang Chun , Wang Shi-Jie , Li Jia-Chen , Xie Xue-Lei , Guan Wen-Bo 
Published: December 2021

Abstract
A new wheeled rolling robot is designed based on planar 3-RRR parallel mechanism and spoke wheel with variable diameter, by adjusting the 3-DOF outputs of the planar 3-RRR parallel mechanism, the deformation and rolling motion of the rolling robot are realized, the rotation output of the parallel mechanism realizes the differential change of the diameter of the two supporting wheels of the rolling robot, and the moving output of the parallel mechanism changes the mass distribution of the system, so that the rolling robot can complete the forward, backward, turning and other motions. Based on the introduction of the performance parameters, driving system, variable diameter wheel configuration and motion mechanism of the rolling robot, the eccentric driving torque is analysis and the existing space of the eccentric torque is given, so as to further complete the selection of the driving motor of the robot. This article analysis three typical motions of robots and its performance parameters, such as straight movement, turn movement, climbing exercise, and builds a simple prototype under laboratory conditions to verify the feasibility of the three movements.
Low-Dose Cone-Beam CT Iterative Reconstruction via Total Variation and Gradient Total Variation
Authors: Cui Junlong , Yu Gang 
Published: December 2021

Abstract
The compressed sensing (CS) technique has been utilized to reconstruct Cone-beam computed tomography (CBCT) images via limited projection from under-sampled measurements. However, the condition of limited projection is an ill-posed problem. Since the CBCT image itself doesn’t have sparse features, the total variation (TV) transform has been widely adopted in CBCT reconstruction. This method, which penalizes the weight of each voxel at a constant rate regardless of different spatial gradient, may not recover qualified CBCT images from ill-posed projection data. This work presents a new strategy to deal with the deficits stated above by utilizing non-uniform weighting penalization in CBCT reconstruction. The proposed new strategy combines TV and gradient total variation (GTV) for reconstruction in a hybrid weighting penalization way, where the total variation is penalized by the gradient total variation in advance. The proposed penalty not only retains the benefits of TV, including artifact and noise suppression, but also maintains the structures in regions with gradual gradient intensity transition more effectively. This study tested the proposed method by under-sampled projections of 2 objects and 2 experiments (2 digital phantom). We assessed its performance against the OS-SART method, FDK method, conventional TV method and TV+GTV method in the tissue contrast, reconstruction accuracy, and imaging resolution by comparing the root mean squared error (RMSE), the correlation coefficient (CC), the structural similarity (SSIM), and profiles intensity of the reconstructed images. The proposed method produced the reconstructed image with the lowest RMSEs and the highest CCs and SSIMs for each experiment.
Population-based Estimates of Overtreatment with Adjuvant Systemic Therapy in Early Breast-cancer Patients with Data from the Netherlands and the USA
Authors: Ragusi Max , Velden Bas H.M. van der , Maaren Marissa C. van , Wall Elsken van der , Gils Carla H. van , Pijnappel Ruud M. , Gilhuijs Kenneth G.A. , Elias Sjoerd G. 
Published: December 2021

Abstract
Purpose: Although adjuvant systemic therapy (AST) helps increase breast cancer-specific survival (BCSS), there is a growing concern for overtreatment. By estimating the expected BCSS of AST using PREDICT, this study aims to quantify the number of patients treated with AST without benefit to provide estimates of overtreatment.Methods: Data of all non-metastatic unilateral breast cancer patients diagnosed in 2015 were retrieved from cancer registries from The Netherlands and the USA. The PREDICT tool was used to estimate AST survival benefit. Overtreatment was defined as the proportion of patients that would have survived regardless of or died despite AST within 10 years. Three scenarios were evaluated: actual treatment, and recommendations by the Dutch or USA guidelines.Results: 59.5% of Dutch patients were treated with AST. 6.4% (interquartile interval [IQI] = 2.5, 8.2%) was expected to survive at least 10 years due to AST, leaving 93.6% (IQI = 91.8, 97.5%) without AST benefit (overtreatment). The lowest expected amount of overtreatment was in the targeted and chemotherapy subgroup, with 86.5% (IQI = 83.4, 89.6%) overtreatment, and highest in the only endocrine treatment subgroup, with 96.7% (IQI = 96.0, 98.1%) overtreatment. Similar results were obtained using data from the USA, and guideline recommendations.Conclusion: Based on PREDICT, AST prevents 10-year breast cancer death in 6.4% of the patients treated with AST. Consequently, AST yields no survival benefit to many treated patients. Especially improved personalization of endocrine therapy is relevant, as this therapy is widely used and is associated with the highest amount of overtreatment.
Effect of Implantoplasty on Fatigue Performance and Surface Roughness of Narrow Diameter Dental Implants
Authors: Camps-Font Octavi , Toledano-Serrabona Jorge , Juiz-Camps Ana , Figueiredo Rui , Gay-Escoda Cosme , Valmaseda-Castellón Eduard 
Published: December 2021

Abstract
Implantoplasty (IP) is used in dental implants with peri-implantitis and aims to remove threads and polish rough surfaces in order to prevent bacterial colonization. As a result of this procedure, implant strength might be compromised. We tested 20 tapered screw-shaped Ti6Al4V dental implants with a simulated bone loss of 50%. Ten implants underwent IP and 10 served as controls. Surface topography (Sa, Sz, Ssk and Sdr) was analyzed with a confocal optical microscope. Subsequently, cyclic loads were applied with a servo-hydraulic mechanical testing machine (5x106 cycles at 15 Hz, between the maximal compression force - 529N in the IP group and 735N in the control group - and 10% of that force). We recorded the number of cycles until failure and the type of failure. Implant failure was analyzed by visual inspection and scanning electron microscopy. Implantoplasty reduced the median Sa from 1.76 (IQR=0.11) to 0.49 (IQR=0.16). The fatigue limits of the control and implantoplasty groups were 551 N and 529 N, respectively. The scanning electron micrographs showed fatigue striations indicating fatigue failure. The infinite life range of the dental implants evaluated was largely above the threshold of usual chewing forces. Implantoplasty seems to render a fairly smooth surface and has a limited impact upon fatigue resistance.
Unconventional COPII-mediated secretory protein trafficking continues in the absence of the Sar1 GTPase
Authors: Kasberg William , Luong Peter , Hanna Michael , Minushkin Kayla , Tsao Annabelle , Lee Hugo Hugo , Engin Feyza , Shankar Raakhee , Block Samuel , Audhya Anjon 
Published: December 2021

Abstract
Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from discrete membrane subdomains. Lipid bilayer remodeling necessary for this process is driven initially by membrane penetration of the coat subunit Sar1 and further stabilized by assembly of a multi-layer complex of several COPII proteins. However, the relative contributions of these distinct factors to transport carrier formation and protein trafficking remain unclear. Here, we demonstrate that anterograde cargo transport from the ER continues in the absence of Sar1, although the unconventional carriers that form fail to efficiently deliver their contents to subsequent compartments in the secretory pathway. Instead, cargoes accumulate immediately adjacent to the perinuclear Golgi under these conditions, together with components of the COPII coat. Our findings highlight new mechanisms by which COPII promotes transport carrier biogenesis and strongly suggests that the Sar1 GTPase plays a critical role in transport carrier uncoating ahead of membrane fusion and secretory cargo delivery at acceptor compartments.