bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Systematic Development of a Mobile Phone Delivered Text-Messaging Tobacco Cessation Intervention in India
Authors: Sequeira Miriam , Naughton Felix , Velleman Richard , Gaikwad Leena , Murthy Pratima , Pacheco Marimilha Grace , D’souza Joseline , Nair Ganga , Shah Rachit , Sambari Seema , Bhatia Urvita , Nadkarni Abhijit 
Published: December 2024

Abstract

Introduction
Tobacco consumption is a leading cause of mortality globally. Eighty percent of these deaths occur in low- and middle-income countries. Despite this, there is a large treatment gap due to both demand and supply-side barriers. Digital interventions are an innovative solution to bridge this gap. We describe the systematic development of ToQuit, a text-messaging intervention for tobacco cessation in India.

Aims and Methods
ToQuit was developed in sequential steps: (1) Identifying Behaviour Change Techniques (BCTs) from evidence-based tobacco cessation interventions; (2) Identifying additional BCTs through in-depth interviews; (3) Online expert survey to rate BCTs on feasibility, acceptability, and perceived effectiveness when delivered via text messaging; and (4) A consultation workshop with practitioners.

Results
Thirty BCTs were identified from steps 1 and 2. Three were excluded in step 3. The final intervention included 27 BCTs delivered over three phases: phase 1—orientation (information about antecedents and consequences of tobacco consumption, goal setting, reattribution, pros and cons of quitting); phase 2—skill building (self-monitoring, avoidance of cues for behavior, behavior substitution, distraction, stress management, handling urges, restructuring physical and social environments, instructions on how to perform a behavior, prompts and cues, problem-solving, social support, and referrals among others); and phase 3—relapse prevention (psychoeducation about lapse and relapse, review goals, action planning, and feedback on behavior). The intervention is delivered via text messages over 8 weeks with 2–3 messages a day, 2–3 days a week.

Conclusions
ToQuit is a contextually relevant and potentially scalable text-messaging intervention for tobacco cessation in resource-constrained settings.

Implications
This manuscript is an important piece in the development of contextually relevant digital interventions for the cessation of both smoked and smokeless forms of tobacco. The detailed description of the steps followed in developing the ToQuit intervention will help others replicate these procedures while developing similar interventions responsive to their contexts; particularly in low- and middle-income countries.
Adherence and Retention in Early or Late Time-Restricted Eating: A Narrative Review of Randomized Controlled Trials
Authors: Lin Yi , Ezzati Armin , McLaren Christian , Zeidan Rola S , Anton Stephen D 
Published: December 2024

Abstract
Time-restricted eating (TRE) is a form of intermittent fasting that involves reducing the time-period in which food is typically consumed daily. While TRE is known to induce health benefits, particularly for adults with obesity, there is currently debate about whether the time of day in which food is consumed also contributes to the health benefits of TRE. Early TRE (eTRE) and late TRE (lTRE) are subtypes of TRE that involve consuming food and caloric beverages either in the early or later part of the day. A growing body of literature indicates that eTRE may offer additional health benefits compared with lTRE. An important and unanswered question, however, is whether most adults can adhere to this type of eating pattern and whether adherence and retention differ between eTRE and lTRE. This narrative review compared adherence and retention in studies that implemented either eTRE or lTRE in adults for 8 weeks or longer. Five databases were searched, and 10 studies met our eligibility criteria. The key finding was that participants had high and comparable levels of adherence and retention in both eTRE and lTRE interventions. Specifically, the mean adherence rate was 81.4% for eTRE and 82.3% for lTRE, while the mean retention rate was 81% for eTRE and 85.8% for lTRE in eligible studies. Thus, the findings support the feasibility of both approaches. The lowest adherence and retention rates occurred in studies in which either eTRE or lTRE regimens were combined with other dietary interventions. Notably, the duration of the eating window did not seem to negatively affect adherence and retention rates for either eTRE or lTRE. More research is warranted to determine the influence of other factors, such as age and study location, on adherence to and retention of both eTRE and lTRE interventions.
Disseminated TB With IRIS Presenting as a Pancreatic Mass in Newly Diagnosed HIV: A Case Report
Authors: Akbar Nina , Mariuz Peter 
Published: December 2024

Abstract
Pancreatic tuberculosis (TB) is an uncommon extrapulmonary presentation of TB. Identification of coinfection with HIV may unmask not only disseminated TB but also immune reconstitution inflammatory syndrome (IRIS). We present the case of a 70-year-old Indian woman newly diagnosed with AIDS and pancreatic tuberculosis with miliary disseminated disease. Her clinical course was complicated by IRIS related to HIV-TB coinfection despite sequential and targeted anti-infective therapies. We review the presentation, pathophysiology, and risk factors for developing IRIS with HIV and pancreatic TB.
Comprehensive performance analysis of an advanced power generation cycle for liquid hydrogen cold energy recovery
Authors: Xia Rui , Wang Jun , Lund Peter D 
Published: December 2024

Abstract
Liquid hydrogen is one of the most efficient ways to store hydrogen. To reduce the energy loss in the liquid hydrogen cycle, the cold energy released at ultra-low temperature in hydrogen regasification should be utilized. Here, an integrated two-stage organic Rankine cycle power generation system for cold energy recovery from liquid hydrogen regasification is proposed. The designed system could recover some 15.3% of the cold energy and increasing the hydrogen cycle exergy efficiency to 71.8%. The working fluid pair R41/R1270 gave the best results and improved the net present value by 2.3%.
Euphagus carolinus (Rusty Blackbird) from two different breeding populations in northeastern North America exhibit chain migration yet use the same region for stopover
Authors: Walker Jacob , Bégin-Marchand Camille , Terrigeol Alexandre , Therrien Jean-François , Côté Pascal , Burford Levi , Foss Carol R , Tremblay Junior A 
Published: December 2024

ABSTRACT
Bird populations within the same species may follow different migratory strategies and phenology depending on their breeding location and latitude, and migratory strategies may be influenced by important stopover sites. Understanding these strategies and identifying important stopover sites is crucial for the conservation of species with regionally varying population trends. In this study, Euphagus carolinus (Rusty Blackbird) from 2 populations in eastern North America were affixed with NanoTag (Lotek) transmitters and tracked using the Motus Wildlife Tracking System to determine migratory routes and connectivity, stopover locations, and wintering areas. During fall migration, birds tagged at Observatoire d’oiseaux de Tadoussac, Québec and breeding sites in New England maintained separate migratory routes north of 43° latitude, as indicated by positive Mantel statistics of migratory connectivity, before converging on stopover areas in the Chesapeake and Delaware Bays region of the mid-Atlantic U.S. Migratory strategy differed between the 2 populations: birds from New England spent ~2 months longer at breeding latitudes than birds from Québec, and Québec birds spent more time at fall stopover sites and wintering latitudes. Birds from both populations made &gt;1-week stopovers during spring and fall migrations and made long-distance (up to 645 km) nocturnal flights. The few winter detections suggested that E. carolinus from New England wintered at more southern latitudes than birds from Québec. Land cover data around stopover sites indicated that E. carolinus were positively associated with percent cover of wooded wetlands, croplands, and hay/pasture. Results from this study could help identify and protect regionally important stopover and wintering areas for E. carolinus, a species that has experienced dramatic long-term population declines linked to habitat loss in the nonbreeding range.
CRISPR/Cas9-mediated mutagenesis of SEED FATTY ACID REDUCER genes significantly increased seed oil content in soybean
Authors: Liao Wenying , Guo Runze , Li Jie , Liu Na , Jiang Lixi , Whelan James , Shou Huixia 
Published: December 2024

Abstract
Increasing seed oil content (SOC) is an important breeding goal for soybean breeding. While significant efforts have been made to improve SOC through metabolic pathway engineering, research to increase soybean SOC by reducing lipid degradation and fatty acid (FA) decomposition during seed maturation process is limited. Seed fatty acid reducers (SFARs) are members of the GDSL enzyme family and play a crucial role in lipid metabolism. Among them, a pair of the GmSFAR4 genes is highly expressed in soybean seeds during seed desiccation and germination. In the study, GmSFAR4a/b double mutants were generated using CRISPR/Cas9-mediated gene editing technique. The seed FA content of GmSFAR4a/b double mutants was significantly increased by ∼8% compared to wild type when grown in greenhouse, and ∼17% when grown in the field, without any adverse effects on seed vitality and plant growth. Our work enriches the understanding of soybean seed oil metabolism and provides a new approach to increase soybean SOC.
Calcium signaling in hypoxic response
Authors: Bakshi Arkadipta , Gilroy Simon 
Published: December 2024

Abstract
Plants can experience a lack of oxygen due to environmental conditions, such as flooding events or intense microbial blooms in the soil, and from their own metabolic activities. The associated limit on aerobic respiration can be fatal. Therefore, plants have evolved sensing systems that monitor oxygen levels and trigger a suite of metabolic, physiologic, and developmental responses to endure, or potentially escape, these oxygen-limiting conditions. Low oxygen stress has long been known to trigger changes in cytosolic Ca2+ levels in plants, and recent work has seen some major steps forward in characterizing these events as part of a Ca2+-based signaling system through (1) defining how hypoxia may trigger and then shape the dynamics of these Ca2+ signals, and (2) identifying a host of the downstream elements that allow Ca2+ to regulate a wide-ranging network of hypoxia responses. Calcium transporters such as the CAX family of Ca2+/H+ antiporters at the tonoplast have emerged as important components of the system that forms hypoxia-related Ca2+ signals. Downstream lies a web of Ca2+-responsive proteins such as the calmodulin like proteins, Ca2+-dependent kinases, and the calcineurin-B like proteins along with their interacting kinases. A host of other regulators such as reactive oxygen species and lipid-mediated signals then act in parallel to the Ca2+-dependent events to closely control and coordinate the myriad responses that characterize the plant's low oxygen response.
Regulation of abscisic acid receptor mRNA stability: Involvement of microRNA5628 in PYL6 transcript decay
Authors: Vieira João G P , Duarte Gustavo T , Barrera-Rojas Carlos H , Matiolli Cleverson C , Viana Américo J C , Campos Raphael de A , Canesin Lucas E D , Vicentini Renato , Nogueira Fabio T S , Vincentz Michel 
Published: December 2024

Abstract
Phytohormone signaling is fine-tuned by regulatory feedback loops. The phytohormone abscisic acid (ABA) plays key roles in plant development and abiotic stress tolerance. PYRABACTIN RESISTENCE 1/PYR1-LIKE/REGULATORY COMPONENT OF ABA RECEPTOR (PYR/PYL/RCAR) receptors sense ABA, and in turn, ABA represses their expression. Conversely, ABA induces expression of Type 2C PROTEIN PHOSPHATASES (PP2C) genes, which negatively regulate the ABA signaling pathway. This regulatory feedback scheme is likely important for modulating ABA signaling. Here, we provide insight into the mechanisms underlying the ABA-induced repression of PYR/PYL/RCAR expression in Arabidopsis (Arabidopsis thaliana). ABA time course analyses revealed strong and sustained repression of PYR/PYL/RCARs, suggesting that receptor gene regulation is an important step in resetting the ABA signaling pathway. Cordycepin-induced transcription inhibition showed that PYL1/4/5/6 mRNA destabilization is involved in the ABA-induced repression of these genes. Furthermore, genetic evidence indicated that decapping may play a role in PYL4/5/6 mRNA decay. We also provide evidence that the Arabidopsis-specific microRNA5628 (miR5628), which is transiently induced by the ABA core signaling pathway, guides PYL6 transcript cleavage in response to ABA. After cleavage, the resulting 5′- and 3′-cleaved fragments of PYL6 mRNA may be degraded by the XRN4 exoribonuclease. miR5628 is an evolutionary novelty that may enhance PYL6 mRNA degradation, along with decapping and XRN4 activity. Thus, regulating the stability of PYR/PYL/RCAR transcripts maintains ABA signaling homeostasis.
Characterizing the Clinical Trajectory and Predicting Persistence and Deterioration of Attenuated Psychotic Symptoms in Ultra-High-Risk Individuals
Authors: Wannan Cassandra , Scott Isabelle , Dwyer Dominic , Clark Scott R , Hartmann Simon , Ye Rochelle Ruby , Amminger G Paul , Yuen Hok Pan , Lavoie Suzie , Markulev Connie , Schaefer Miriam R , Hartmann Jessica A , Mossaheb Nilufar , Schlögelhofer Monika , Smesny Stefan , Hickie Ian B , Berger Gregor , Chen Eric Y H , de Haan Lieuwe , Nieman Dorien H , Nordentoft Merete , Riecher-Rössler Anita , Verma Swapna , Thompson Andrew , Yung Alison R , Kerr Melissa , Spark Jessica , Wallis Nicky , Polari Andrea , McGorry Patrick D , Nelson Barnaby 
Published: December 2024

Abstract

Background
Almost 40% of individuals at ultra-high risk (UHR) for psychosis experience persistent attenuated psychotic symptoms (APS) yet it is unclear (1) whether they share overlapping clinical and functional outcomes compared to individuals who transition to psychosis, (2) when symptom and functioning trajectories begin to diverge between UHR individuals with different clinical outcomes, and (3) whether non-remission (persistent APS or transition) can be predicted using baseline and/or longitudinal data.

Study Design
Participants were drawn from 2 randomized clinical trials: Neurapro (n = 220; discovery sample) and STEP (n = 180; external validation sample). First, 12–24 month symptoms and functioning were compared between UHR individuals with persistent APS, sustained remission, or transition to psychosis. Next, short-term changes in symptoms and functioning were compared between groups to determine timepoints at which trajectories began to diverge. Finally, we used support vector machines to predict non-remission (persistent APS or transition) vs sustained remission using data from baseline, 6-month follow-up, and combined baseline and 6-month follow-up.

Results
Individuals with persistent APS had substantially poorer outcomes compared to those who remitted, and more closely resembled individuals who later transitioned to psychosis. Despite few baseline differences between groups, clinical and functional trajectories of the persistent APS and transition groups rapidly diverged from those who remitted. Prediction of non-remission was poor using baseline data but improved substantially when using 6-month follow-up or combined baseline-6-month data.

Conclusions
Ultra-high-risk individuals with persistent APS display similar clinical and functional trajectories to transitioned cases, suggesting that more intensive and sustained intervention is required for this subgroup. However, prospective identification of individuals with poor clinical outcomes (ie, persistence or deterioration of attenuated psychotic symptoms) may require longitudinal monitoring of symptom and functioning trajectories for several months.
Development and Validation of a Brief Age-Normed Screening Tool for Subthreshold Psychosis Symptoms in Youth
Authors: Calkins Monica E , Ered Arielle , Moore Tyler M , White Lauren K , Taylor Jerome , Moxam Alexander B , Ruparel Kosha , Wolf Daniel H , Satterthwaite Theodore D , Kohler Christian G , Gur Ruben C , Gur Raquel E 
Published: December 2024

Abstract

Background and Hypothesis
Improvements in screening tools for early subthreshold psychosis symptoms are needed to facilitate early identification and intervention efforts, especially given the challenges of rapidly differentiating age-appropriate experiences from potential early signs of emerging psychosis. Tools can be lengthy and time-consuming, impacting their utility and accessibility across clinical settings, and age-normed data are limited. To address this gap, we sought to develop and validate a brief, empirically derived, age-normed, subthreshold psychosis screening tool, for public use.

Study Design
Computerized adaptive test simulation was used to derive a 5-item short form with age norm equivalencies from a 12-item PRIME-Screen-Revised (PRIME-12) administered to 7053 youth (Mage = 15.8, SD = 2.7; 54% female; 33% Black). Concurrent validity was assessed (n = 758) using contemporaneous administration of the PRIME-5 and the Structured Interview for Prodromal Syndromes. Comparability of criterion-related validity of the PRIME-5, PRIME-12, and Scale of Prodromal Symptoms (SOPS) was assessed by relating scores to psychosis-risk-relevant criteria. Finally, self-report versus assessor-administered PRIME total scores were compared (n = 131) to assess their concurrent validity.

Study Results
Correlations among PRIME-5, PRIME-12, and SOPS were comparable and moderate, supporting their convergent validity. The PRIME-5 also showed comparable criterion-related validity, demonstrating similar relationships with psychosis-risk indicators as the other tools. Self-reported and assessor-administered PRIME-5 were moderately correlated.

Conclusions
Public availability of a brief, age-normed, and validated screening tool—which can be assessor or self-administered—will expedite and improve early identification of youth (age 11 and older) at risk for psychosis.
NK cell cytotoxicity towards pluripotent stem cells and their neural progeny: impacts of activating and inhibitory receptors and KIR/HLA mismatch
Authors: Henden Camilla , Fjerdingstad Hege B , Bjørnsen Elisabeth G , Thiruchelvam-Kyle Lavanya , Daws Michael R , Inngjerdingen Marit , Glover Joel C , Dissen Erik 
Published: December 2024

Abstract
Pluripotent stem cells provide opportunities for treating injuries and previously incurable diseases. A major concern is the immunogenicity of stem cells and their progeny. Here, we have dissected the molecular mechanisms that allow natural killer (NK) cells to respond to human pluripotent stem cells, investigating a wide selection of activating and inhibitory NK cell receptors and their ligands. Reporter cells expressing the activating receptor NKG2D responded strongly to embryonic stem (ES) cell lines and induced pluripotent stem (iPS) cell lines, whereas reporter cells expressing the activating receptors NKp30, NKp46, KIR2DS1, KIR2DS2 and KIR2DS4 did not respond. Human ES and iPS cells invariably expressed several ligands for NKG2D. Expression of HLA-C and HLA-E was lacking or low, insufficient to trigger reporter cells expressing the inhibitory receptors KIR2DL1, -2DL2 or -2DL3. Similar results were obtained for the pluripotent embryonic carcinoma cell lines NTERA-2 and 2102Ep, and also iPS cell-derived neural progenitor cells. Importantly, neural progenitor cells and iPS cell-derived motoneurons also expressed B7H6, the ligand for the activating receptor NKp30. In line with these observations, IL-2 stimulated NK cells showed robust cytotoxic responses to ES and iPS cells as well as to iPS cell-derived motoneurons. No significant differences in cytotoxicity levels were observed between KIR/HLA matched and mismatched combinations of NK cells and pluripotent targets. Together, these data indicate that pluripotent stem cells and their neural progeny are targets for NK cell killing both by failing to sufficiently express ligands for inhibitory receptors and by expression of ligands for activating receptors.
Can pension fund design increase pension savings? Evidence from a conjoint experiment in six European countries
Authors: Fernández Juan J , Gonzales Sara , James Hayley , Wiß Tobias 
Published: December 2024

Abstract
In times of welfare state retrenchment, occupational pension savings become essential for ensuring adequate retirement income. We know that individuals’ socioeconomic characteristics and a country’s characteristics matter for the level of occupational pension plan (OPP) savings. However, there is a gap in knowledge regarding how pension fund design affects pension savings. This paper fills this gap by examining the influence of OPP characteristics on the willingness of individuals to increase their contribution level. We analyze a conjoint experiment embedded in an online representative survey conducted in Austria, Denmark, Germany, Ireland, The Netherlands, and Spain. The plans differed across seven attributes. The results indicate that (i) past financial returns, (ii) the structure of the OPP board, and (iii) board responsiveness to participants’ demands have the strongest effects, followed by current (iv and v) contributions by employees and employers and (vi) environmental, social, and governance (ESG) policies. The type of (vii) tools used to inform participants proves unrelated to OPP selection.
Deficiency of DDI2 suppresses liver cancer progression by worsening cell survival conditions
Authors: Liu Keli , Hu Shaofan , Wufuer Reziyamu , Zhang Qun , Qiu Lu , Zhang Zhengwen , Wang Meng , Zhang Yiguo 
Published: December 2024

AbstractThe levels of reactive oxygen species (ROS) and the extent of ensuing DNA damage significantly influence cancer initiation and progression. Of crucial importance, the aspartate protease DDI2 has been proposed to play a pivotal role in monitoring intracellular ROS levels (to trigger oxidative eustress or distress), as well as in the oxidative DNA damage repair, through redox homeostasis-determining factor Nrf1 (encoded byNFE2L1). However, the specific role of DDI2 in the multi-step process resulting in the development and progression of liver cancer remains elusive to date. In the present study, we employed the CRISPR/Cas9 gene editing system to create two nuanced lines ofDDI2knockout (i.e.,DDI2−/−andDDI2insG/−) from liver cancer cells. Subsequent experiments indicate that the knockout ofDDI2leads to increased ROS levels in hepatoma cells by downregulating two major antioxidant transcription factors Nrf1 and Nrf2 (encoded byNFE2L2), exacerbating endogenous DNA damages caused by ROS and not-yet-identified factors, thereby inhibiting cell proliferation and promoting apoptosis, and ultimately hinderingin vivomalignant growth of xenograft tumor cells. Conversely, the restoration of DDI2 expression reverses the accumulation of ROS and associated DNA damage caused byDDI2knockout, eliminating the subsequent inhibitory effects ofDDI2deficiency on bothin vitroandin vivogrowth of liver cancer cells. Collectively, these findings demonstrate thatDDI2deficiency impedes liver tumor growth by disrupting its survival environment, suggesting that DDI2 may serve as a novel therapeutic target for anti-cancer strategies aimed at modulating ROS or DNA damage processes.