bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermo-Economic Comparison Between Organic Rankine Cycle and Binary-Flashing Cycle for Geothermal Energy
Authors: Zhao Yuan , Du Bowen , Chen Shunyi , Zhao Jun , Gong Yulie , Bu Xianbiao , Li Huashan , Wang Lingbao 
Published: October 2021

Geothermal energy is a characteristic of widely distributed, high capacity factor, high reliability, and lower environmental impact potential values. And it will play an important role in achieving the goal of carbon neutral carbon peak. Nonetheless, geothermal energy presents its own particular challenges, i.e., the high investment cost and long payback period. The binary flashing cycle (BFC) system is proved to be a promising power generation technology due to the efficient and full utilization of a low-grade heat source. While the economic performance still needs further evaluation, in the present study, the thermo-economic comparison between organic Rankine cycle (ORC) and the BFC for geothermal energy has been investigated. R245fa has been chosen as the working fluid. Considering the thermodynamic and economic performance simutaneously, several evaluation indicators were selected including thermal efficiency, exergy efficiency, net power output per ton geothermal water, heat exchanger area, and heat recovery efficiency, and the system modeling and comparison were presented. The simulation results reveal that the BFC system obtains 32% more net power output than the ORC system under the working conditions investigated. The heat recovery efficiency of the BFC is 1.96 times as much as that of the ORC, which indicates that the BFC can realize the full utilization of low-grade energy. And more heat exchanger areas are required in the BFC system. What is more, the preliminary discussion of the economic feasibility of BFC system applied in the FengShun geothermal power plant is presented. The payback period of the BFC is just 6.0 years under the generation pressure of 600 kPa. It is indicated that the BFC system has obvious economic benefits, especially in a nonflowing geothermal well.
Effective Treatment of Postherpetic Neuralgia at the First Branch of the Trigeminal Nerve by High-Voltage Pulsed Radiofrequency
Authors: Li Hongxi , Ding Yuanyuan , Zhu Yongqiang , Han Zhenkai , Yao Peng 
Published: October 2021

Background: Postherpetic neuralgia (PHN) is one of the most common and serious complications of herpes zoster. PHN of the first branch of the trigeminal nerve is painful and difficult to treat, as no definitive effective treatment is available. The aim of this retrospective study was to observe the efficacy and safety of treatment of PHN of the first branch of the trigeminal nerve with high-voltage pulsed radiofrequency (PRF) of the supraorbital nerve.Methods: Fifty-two patients diagnosed with the PHN of the first branch of the trigeminal nerve at the Department of Pain Management, Shengjing Hospital, China Medical University, between April 2017 and October 2020 were selected. The PRF treatment of the supraorbital nerve was used. The patients were divided into two groups according to the treatment received: group C, conventional PRF group; and group H, high-voltage PRF group. The basic conditions, pain scores, and SF-36 scores of patients before treatment were recorded. Also, intraoperative and postoperative adverse events, visual analog scale (VAS) scores, 36-Item Short Form Health Survey (SF-36) scores at 1 week, 1 month, 3 months, and 6 months of follow-up were recorded. Furthermore, treatment efficiency was followed up at 6 months after treatment.Results: The VAS scores of patients in both groups were significantly lower at all time points after treatment compared with presurgery. VAS scores in group H were lower than those in group C 1, 3, and 6 months after treatment. SF36 scores of patients in group H were better than those in group C 1, 3, and 6 months after treatment. The treatment efficiency at 6 months after treatment was higher in group H than in group C. No serious adverse events occurred in both groups.Conclusion: The efficacy of the high-voltage PRF of the supraorbital nerve in treating the PHN of the first branch of the trigeminal nerve was superior to that of conventional PRF. It was a safe and effective treatment method.
CT Radiomics Model for Predicting the Ki-67 Index of Lung Cancer： An Exploratory Study
Authors: Fu Qing , Liu Shun li , Hao Da peng , Hu Ya bin , Liu Xue jun , Zhang Zaixian , Wang Wen hong , Tang Xiao yan , Zhang Chuan yu , Liu Shi he 
Published: October 2021

ObjectiveTo establish a radiomics signature and a nomogram model based on enhanced CT images to predict the Ki-67 index of lung cancer.MethodsFrom January 2014 to December 2018, 282 patients with lung cancer who had undergone enhanced CT scans and Ki-67 examination within 2 weeks were retrospectively enrolled and analyzed. The clinical data of the patients were collected, such as age, sex, smoking history, maximum tumor diameter and serum tumor markers. Our primary cohort was randomly divided into a training group (n=197) and a validation group (n=85) at a 7:3 ratio. A Ki-67 index ≤ 40% indicated low expression, and a Ki-67 index &gt; 40% indicated high expression. In total, 396 radiomics features were extracted using AK software. Feature reduction and selection were performed using the lasso regression model. Logistic regression analysis was used to establish a multivariate predictive model to identify high and low Ki-67 expression in lung cancer. A nomogram integrating the radiomics score was established based on multiple logistic regression analysis. Area under the curve (AUC) was used to evaluate the prediction efficiency of the radiomics signature and nomogram.ResultsThe AUC,sensitivity, specificity and accuracy of the radiomics signature in the training and validation groups were 0.88 (95% CI: 0.82~0.93),79.2%,84.3%,81.2% and 0.86 (95% CI: 0.78~0.94),74.6%,88.1%,79.8%, respectively. A nomogram combining radiomics features and clinical risk factors (smoking history and NSE) was developed. The AUC, sensitivity, specificity and accuracy were 0.87 (95% CI: 0.80~0.95), 75.0%, 90.2% and 83.5% in the validation group, respectively.ConclusionThe radiomics signature and nomogram based on enhanced CT images provide a way to predict the Ki-67 expression level in lung cancer.
Tnfaip6 Secreted by Bone Marrow–Derived Mesenchymal Stem Cells Attenuates TNBS-Induced Colitis by Modulating Follicular Helper T Cells and Follicular Regulatory T Cells Balance in Mice
Authors: Gu Guangli , Lv Xiaodan , Liu Gengfeng , Zeng Ruizhi , Li Shiquan , Chen Lan , Liang Zhaoliang , Wang Huiqin , Lu Fei , Zhan Lingling , Lv Xiaoping 
Published: October 2021

Objective: To investigate the immunological mechanism of bone marrow–derived mesenchymal stem cells (BM-MSCs) in inflammatory bowel disease (IBD).Methods: Mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)–induced colitis were intraperitoneally injected with phosphate-buffered saline, BM-MSCs, BM-MSCs with tumor necrosis factor–induced protein 6 (Tnfaip6) knockdown mediated by RNA interference recombinant adenovirus, and BM-MSCs–infected with control adenovirus or recombinant mouse Tnfaip6. The disease activity index, weight loss, and histological scores were recorded. Serum levels of Tnfaip6 and pro- and anti-inflammatory cytokines, including interleukin (IL)-21, tumor necrosis factor-alpha (TNF-α), IL-10 were measured by enzyme-linked immunosorbent assay. The relative expression levels of these cytokines, B-cell lymphoma 6 (BCL-6) and fork-like transcription factor p3 (Foxp3) in the colon were determined by real-time quantitative PCR (RT-qPCR). BCL-6 and Foxp3 are the master regulators of follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr), respectively. The infiltration of Tfh and Tfr in mesenteric lymph nodes (MLNs) and spleens was analyzed by flow cytometry.Results: Compared to the normal control group, the expression levels of BCL-6 and IL-21 in the colon, Tfh infiltration, and ratios of Tfh/Tfr in the MLNs and spleen, and the serum concentrations of IL-21 and TNF-α increased significantly in the colitis model group (p &lt; 0.05). Intraperitoneal injection of BM-MSCs or Tnfaip6 ameliorated weight loss and clinical and histological severity of colitis, downregulated the expression of BCL-6, IL-21, and TNF-α, upregulated the expression of Foxp3, IL-10, and Tnfaip6 (p &lt; 0.05), increased Tfr and reduced the infiltration of Tfh in the MLNs and spleen, and downregulated the Tfh/Tfr ratio (p &lt; 0.05). On the other hand, BM-MSCs lost the therapeutic effect and immune regulatory functions on Tfh and Tfr after Tnfaip6 knockdown.Conclusion: Tfh increase in the inflamed colon, Tfh decrease and Tfr increase during the colitis remission phase, and the imbalance of the Tfh/Tfr ratio is closely related to the progression of IBD. Tnfaip6 secreted by BM-MSCs alleviates IBD by inhibiting Tfh differentiation, promoting Tfr differentiation, and improving the imbalance of Tfh/Tfr in mice.
How Singing can Help People With Dementia and Their Family Care-Partners: A Mixed Studies Systematic Review With Narrative Synthesis, Thematic Synthesis, and Meta-Integration
Authors: Thompson Zara , Baker Felicity A. , Tamplin Jeanette , Clark Imogen N. 
Published: October 2021

Background: Recent research on the efficacy of music-based interventions for people with dementia have focused on specific outcomes and methods, and singing has been noted as a particularly beneficial activity. However, due to heterogeneity of research methods, there is a need to synthesise the findings of both quantitative and qualitative research in order to better understand both the impact and potential mechanisms of singing for people in this population.Method: This systematic review included quantitative, qualitative and mixed-methods studies, and analysed these using a systematic mixed-studies synthesis (with a results-based convergent approach). Quantitative and qualitative data were initially synthesised using a narrative synthesis and thematic synthesis method, respectively, before a final meta-integration method was used to synthesise common themes across the two data forms.Results: Electronic and hand search strategies revealed 1,815 relevant studies, 40 of which met the full eligibility criteria. Narrative synthesis of quantitative data revealed six key outcome areas (quality of life; psychological well-being; cognition; engagement; activities of daily living; care-partner well-being), and thematic synthesis of qualitative data generated seven themes relating to the impact and mechanisms of singing (pragmatic elements; social benefits; mood; identity; memory; flow-on effects; and relationships). Meta-integration identified four key areas relating to the impact and mechanisms of singing for people with dementia and care-partners: psychological well-being, quality of life, cognition, and care-partner well-being.Conclusion: Results from the syntheses suggest that singing can positively impact the lives of people with dementia and their care-partners, although due to heterogeneity of study design and outcome measures, it is difficult to draw conclusions based on quantitative data alone. Qualitative data provides further context and insights from participant perspectives, and when integrated with quantitative data, contextual factors that may influence the benefits that participants experience from singing are revealed.
Correlation Between Body Mass Index and Anterolateral Thigh Flap Thickness: A Retrospective Study From a Single Center in China
Authors: Yin Jianxin , Wang Lei , Yang Gongxin , Qin Xingjun , Xiong Ping 
Published: October 2021

Background: During repair of oral and maxillofacial soft tissue defects, organ function is largely related to the amount of thickness of the flap. However, there are few studies on the influencing factors of the thickness of the flap. In this retrospective study, we aim to explore the correlation between body mass index (BMI) and anterolateral thigh (ALT) flap thickness by computed tomography (CT) and ultrasound and provide guidance for evaluating the ALT flap thickness before surgery.Methods: We selected three points A, B, and C on ALT flap and two skilled clinicians measured the thickness of these points. Age and gender as covariates and evaluated by the Chi-square analysis. Inter-group differences between the two BMI groups were examined by the student t test. Intra-group differences within each BMI group were tested by ANOVA. Linear regression analysis was performed to examine the relationship between BMI and ALT flap thickness.Results: One hundred sixty patients measured by CT were included in this study, and the ALT flap thickness measured by CT were 8.96 mm and 11.00 mm (P &lt; 0.0001, t test) at point B in groups with BMI&lt;24.0 and BMI≥24.0, respectively. The thicknesses at points A, B, and C were significantly correlated with the BMI (P &lt; 0.001, correlation analysis, r = 0.462, 0.372, and 0.349 at the points A, B, and C, retrospectively, Pearson test).Conclusion: There was a significant correlation between the ALT flap thickness and BMI. A higher BMI was correlated with a thicker ALT flap.
Perfil de diversidade florística e padrão espacial de espécies arbóreas em florestas com ocorrência de bambu na Amazônia
Authors: Leal Glória da Silva Almeida , Assis Leal Fabrício , Da Silva Almeida da Cruz Adriana 
Published: October 2021

No Acre encontra-se a maior reserva de bambu nativo do mundo, todavia esses ambientes ainda são poucos estudados. Logo, conhecer sua florística e estrutura é fator chave para o manejo e conservação desses ecossistemas. Assim, objetivou-se neste trabalho avaliar se o bambu afeta a diversidade e a estrutura espacial de espécies florestais nativas. Para obtenção dos dados realizou-se um inventário em áreas de Floresta Aberta com Palmeira e Bambu (FAPB) e Floresta Aberta com Palmeira (FAP), localizadas no Acre. Dos dados oriundos do inventário realizou-se a análise de cluster a fim de verificar a similaridade entre as áreas. Para comparar a diversidade florística foram avaliados o perfil de diversidade e o índice de Shannon. Já a estrutura espacial das espécies foi verificada pelo índice de Morisita. Os resultados apontaram maior diversidade florística para PAPB (H’ = 3,83 e J = 0,87) em relação a FAP (H’ = 3,55 e J = 0,78), com diferença significativa ao nível de 5% de significância. A similaridade entre as áreas FAPB e FAP foi considerada baixa, apenas 28% das espécies são comuns as duas áreas. E quanto a estrutura espacial, as espécies apresentaram padrão de distribuição semelhante (agregado) tanto na FAPB quanto na FAP. Desta forma, concluiu-se que o bambu não afetou a diversidade florística, tão pouco a estrutura espacial das espécies, isto porque a ocorrência do bambu pode estar relacionada a existência das espécies.
Offset-locking-based frequency stabilization of external cavity diode lasers for long-distance quantum communication
Authors: Miyashita Takuto , Kondo Takeshi , Ikeda Kohei , Yoshii Kazumichi , Hong Feng-Lei , Horikiri Tomoyuki 
Published: October 2021

Abstract
Quantum repeaters are required for long-distance quantum communication. For efficient coupling of quantum entangled photon sources with narrow-linewidth quantum memories, we performed the frequency stabilization of two lasers at 1514 and 1010 nm. The 1514 nm pump laser of the entangled photon source exhibited a frequency stability of 3.6 × 10–12 (τ = 1 s). The 1010 nm pump laser of the wavelength conversion system exhibited a frequency stability of 3.4 × 10–12 (τ = 1 s). The stabilities of both lasers were approximately two orders of magnitude smaller than the frequency width of 4 MHz of the Pr:YSO quantum memory. Such frequency-stabilized lasers can realize the remote coupling of a quantum memory and an entangled photon source in quantum repeaters.
The Effect of Shallot Extract and Auxin-Plant Growth Regulators on the Growth of Mucuna bracteata D.C.
Authors: Prameswari Silvana , Pratomo Bayu 
Published: October 2021

Introduction: This study aims to obtain concentration of shallot extract (Allium cepa ) and growth regulators to increase growth of Mucuna bracteata. Mucuna is a land cover plant that must be planted in oil palm plantation areas. It is very important to be able to cover the planting area.
Materials and Methods: This study used two factorial in randomized block design. The first was concentration of shallot extract per 100 ml distilled water consists of 4 levels, such as control (B0), 10 cc (B1), 20 cc (B2), 30 cc (B3) and the second was the auxins-plant growth regulator consists of 4 levels: Control (G0), 100 ppm (G1), 200 ppm (G2), 300 ppm (G3). Data analyzed with ANOVA with a significant 5% and continued with the DMRT using SAS version 9.1.3.
Results: It was found that effect of concentration of shallot extract had a significant effect on survival percentage of Mucuna bracteata at a concentration of 10 cc (B2) after opening the lid at four weeks after planting (WAP) and did not change until 8 WAP. Likewise, the number of leaves at the control concentration (B0) at the age of 6 WAP, and a concentration of 10 cc (B1) at the age of 7-8 WAP. The concentration of growth regulators and their interactions did not significantly affect the survive percentage and number of leaves in Mucuna bracteata.
TINDAK TUTUR ILOKUSI DALAM UJARAN ENG TAY DALAM GEGURITAN ‘SAMPIK TONG NAWANG NATAH’
Authors: I Komang Sulatra  , Desak Putu Eka Pratiwi  , I Gusti Bagus Wahyu Putra Nugraha  
Published: October 2021

This study aims at finding out the types of illocutionary act and explaining the meaning of utterances found in Balinese traditional literary work named geguritan entitled ‘Sampik tong Nawang Natah’. The method in collecting the data was observation method by reading the script of geguritan Sampik tong nawang Natah and note taking the lyrics which have the illocutionary act spoken by one of the main characters ‘Eng Tay’. The analysis was done by applying the theory of speech act by Searle (1969) related to the types of illocutionary act. This study found that Eng Tay used assertive, directive, commissive and expressive illocutionary act. This study also shows the misinterpretation of the utterance which exists in the utterances spoken by Eng Tay has made fatal result. Sampik was fault to catch the meaning therefore he couldn’t able to marry Eng Tay. Geguritan Sampik has shown how ambiguities can make problem in communication. This study also shows the important of pragmatics in relation to understand the speakers meaning, the listeners have to be able to interpret the meaning of utterances based on the context..
Abstrak
Penelitian ini bertujuan untuk mengetahui jenis tindak tutur ilokusi dan menjelaskan tentang makna tuturan yang diujarkan oleh Eng Tay dalam karya sastra tradisional Bali yaitu geguritan berjudul Sampik tong Nawang Natah. Penelitian ini menggunakan metode observasi atau metode simak dengan membaca naskah geguritan dan juga mencatat tuturan yang diujarkan oleh karakter utama yaitu Eng Tay. Analisis data dilakukan dengan menerapkan teori speech act oleh Searle (1969) berkaitan dengan tipe tindak tutur ilokusi. Hasil penelitian ini menunjukkan bahwa Eng Tay mengujarkan tindak tutur ilokusi tipe asertif, direktif, komisif dan ekspresif. Penelitian ini juga menunjukkan bagaimana kesalahan interpretasi terhadap makna tuturan telah mengakibatkan hal yang buruk. Sampik gagal memaknai tuturan Eng Tay sehingga dia tidak bisa menikah dengan Eng Tay. Geguritan Sampik juga menunjukan bagaimana ambiguitas makna memunculkan permasalahan dalam komunikasi. Penelitian ini menjelaskan bahwa memahami makna pragmatic sebuah tuturan sangatlah penting, penyimak harus mampu menginterpretasi makna berdasarkan konteks.
RAGAM BAHASA DALAM VIDEO YOUTUBER JEPANG
Authors: Ni Wayan Meidariani  
Published: October 2021

This research discusses about the Japanese language variation looked at from the perspective of its speakers and usages. The use of Japanese based on its speakers’ positions in the society is known to have three varieties such as sonkeigo, teineigo and futsugo. It is the speaker, the context and the situation which determine the distinctive use of either one of the three styles in the daily conversation. This article focuses on the variety of Japanese language on youtuber videos. The purpose of this study is to increase the Japanese learners’ knowledge on different kinds of Japanese varieties used in daily communication, such as trending vocabulary in Japan. The data are collected from Japan youtuber videos Hikakin TV on youtube. The approach used in this study is a qualitative approach. Methodologically, the data found are processed descriptively. The writer found that Japanese youtubers use futsugo and teineigo in their speech. The analysis also reveals that they use the word patterns of ryuukougo and wakamonokotoba in their use of adjectives, verbs as well as adverbials. The pattern of wakamono kotoba processes of shortening in the middle and the end of a word, changing sound in some words, borrowing, and adding -i to a word that changes the word class into an adjective are also found.
Abstrak
Penelitian ini membahas tentang ragam bahasa Jepang berdasarkan penutur ditinjau dari penutur dan penggunaannya. Ragam bahasa Jepang berdasarkan penutur dikenal dengan ragam sonkeigo, teineigo dan futsugo yang penggunaannya berbeda berdasarkan penutur dan konteks penggunaanya. Ragam futsuugo biasanya digunakan dalam percakapan sehari-hari, dimana penuturnya memiliki hubungan kedekatan dengan lawan tutur. Sedangkan ragam sonkeigo digunakan untuk menunjukkan kesantunan berbicara terhadap lawan bicara. Berdasarkan hal tersebut, maka tulisan ini memfokuskan pada variasi bahasa Jepang yang digunakan youtuber Jepang pada chanel hikakin TV dalam media youtube. Penelitian ini berkontribusi dalam menambah pengetahuan para pembelajar bahasa Jepang untuk memahami variasi bahasa Jepang yang digunakan dalam ragam kasual yakni penggunaan kosakata yang sedang trend di Jepang saat ini. Sumber data yang digunakan dalam tulisan ini berupa video dari youtuber Jepang pada akun chanel Hikakin TV dalam media Youtube. Tulisan ini menggunakan pendekatan secara kualitatif. Berdasarkan hasil analisis, para youtuber Jepang menggunakan ryuukougo dan wakamono kotoba dalam tuturan. Ryuukougo dan wakamono kotoba yang sering digunakan dalam bentuk adjektiva, verba dan adverbial. Pola pembentukkan wakamono kotoba ditemukan dalam bentuk proses pemendekkan di tengah dan di akhir kata, perubahan bunyi pada kata, peminjaman kosakata bahasa asing dan penambahan -i pada sebuah kata sehingga mengubah kelas kata tersebut menjadi kelas adjektiva.
The Efficacy of Topical 0.03% Tacrolimus Dermatologic Ointment in Treatment of Vernal Keratoconjunctivitis
Authors: Adnan Muhammad , Masrur Amena , Khan Furqan Ahmed , Tayyab Ali 
Published: October 2021

Objective: To determine the efficacy of 0.03% Tacrolimus dermatologic ointment in the treatment of Vernalkeratoconjunctivitis.Study Design: Cross-sectional.Place and Duration of Study: The study was conducted at Eye Donors Association Hospital, Wah Cantonmentfrom August 2019 to January 2020.Materials and Methods: 103 diagnosed patients ofvernal keratoconjunctivitis, aged 3-16 years, were includedin this study. They were treated with 0.03% Tacrolimus dermatologic ointment,applied in the inferior fornixonce at night time, for a period of two months. In addition, these patients were also prescribeda topical antihistamine(0.05 % ketotifen eye drops 3 times a day)and preservative free artificial tearsfor symptomatic relief.The patients were evaluated at 4 and 8 weeks after the initiation of treatment. At each follow up the clinicalsigns were assessed on a slit lamp biomicroscope by a single observer and recorded on a standardized gradingsheet.Results: Out of 103 patients, 66% were male and mean age was 9 years (range 3-16 years). The mean baselinescores showed a statistically significant decrease, with the exception of palpebral follicles & limbal Trantas dotsafter 8 weeks of treatment.Conclusion: 0.03% Tacrolimus dermatologic ointment was found to be safe and effective in the treatment ofvernal kerato-conjunctivitis.