bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic behavior of precast reinforced concrete column-to-foundation grouted duct connections
Authors: Hofer Lorenzo , Zanini Mariano Angelo , Faleschini Flora , Toska Klajdi , Pellegrino Carlo 
Published: July 2021

AbstractThe paper shows the results of an experimental campaign aimed at investigating the cyclic behavior of a column-to-foundation joint for precast concrete elements. The tested connection is realized adopting corrugated steel ducts embedded into the foundation, in which column protruding rebars are anchored by grouting high performance mortar. The experimental program consists in testing six full-scale reinforced concrete square-section columns subject to quasi-static cyclic lateral load with a constant axial compression. A preliminary series of bond tests was carried out to define some experimental variables, i.e., longitudinal rebar diameter and anchorage length. Results of the precast joints are compared with those of two reference cast-in-place specimens with the same geometric characteristics, showing similar hysteretic behavior, energy dissipation and ductility values. Lastly, the plastic hinge height is computed for all the specimens based on experimental concrete strains, and compared to current codes formulations.
Ice giant system exploration within ESA’s Voyage 2050
Authors: Fletcher Leigh N. , Helled Ravit , Roussos Elias , Jones Geraint , Charnoz Sébastien , André Nicolas , Andrews David , Bannister Michele , Bunce Emma , Cavalié Thibault , Ferri Francesca , Fortney Jonathan , Grassi Davide , Griton Léa , Hartogh Paul , Hueso Ricardo , Kaspi Yohai , Lamy Laurent , Masters Adam , Melin Henrik , Moses Julianne , Mousis Oliver , Nettleman Nadine , Plainaki Christina , Schmidt Jürgen , Simon Amy , Tobie Gabriel , Tortora Paolo , Tosi Federico , Turrini Diego 
Published: July 2021

AbstractOf all the myriad environments in our Solar System, the least explored are the distant Ice Giants Uranus and Neptune, and their diverse satellite and ring systems. These ‘intermediate-sized’ worlds are the last remaining class of Solar System planet to be characterised by a dedicated robotic mission, and may shape the paradigm for the most common outcome of planetary formation throughout our galaxy. In response to the 2019 European Space Agency call for scientific themes in the 2030s and 2040s (known as Voyage 2050), we advocated that an international partnership mission to explore an Ice Giant should be a cornerstone of ESA’s science planning in the coming decade, targeting launch opportunities in the early 2030s. This article summarises the inter-disciplinary science opportunities presented in that White Paper [1], and briefly describes developments since 2019.
Study on the cohesive edge crack in a square plate with the cohesive element method
Authors: Kellner Leon , Lu Wenjun , Ehlers Sören , Høyland Knut V. 
Published: July 2021

AbstractThe size of the fully developed process zone (FDPZ) is needed for the arrangement of displacement sensors in fracture experiments and choosing element size in numerical models using the cohesive element method (CEM). However, the FDPZ size is generally not known beforehand. Analytical solutions for the exact FDPZ size only exist for highly idealised bodies, e.g. semi-infinite plates. With respect to fracture testing, the CEM is also a potential tool to extrapolate laboratory test results to full-scale while considering the size effect. A numerical CEM-based model is built to compute the FDPZ size for an edge crack in a finite square plate of different lengths spanning several magnitudes. It is validated against existing analytical solutions. After successful validation, the FDPZ size of finite plates is calculated with the same numerical scheme. The (FDPZ) size for finite plates is influenced by the cracked plate size and physical crack length. Maximum cohesive zone sizes are given for rectangular and linear softening. Further, for this setup, the CEM-based numerical model captures the size effect and can be used to extrapolate small-scale test results to full-scale.
The Impact of COVID-19 on Anxiety and Worries for Families of Individuals with Special Education Needs and Disabilities in the UK
Authors: Sideropoulos V. , Dukes D. , Hanley M. , Palikara O. , Rhodes S. , Riby D. M. , Samson A. C. , Van Herwegen J. 
Published: July 2021

AbstractCOVID-19 has affected people across the world. The current study examined anxiety and worries during the first UK national lockdown in March 2020. Parents (n = 402) reported on their own anxiety and worries as well as that of their son/daughter with Special Education Needs and Disabilities (SEND) and typically developing (TD) child (n = 186) at three time points. Although both groups showed increased anxiety across the three time points, levels of anxiety in the SEND group, but not the TD siblings, were predicted by awareness about COVID-19. In addition, worries differed between the groups showing that COVID-19 impacts the wellbeing of those with SEND differently to that of their TD siblings.
Self-lubricating triboactive (Cr,Al)N+Mo:S coatings for fluid-free applications
Authors: Bobzin K. , Brögelmann T. , Kalscheuer C. , Thiex M. 
Published: July 2021

AbstractWithin this study, self-lubricating and triboactive (Cr,Al)N+Mo:S coatings were developed and investigated for the deposition on components in a low-temperature physical vapor deposition (PVD) hybrid process. Therefore, direct current magnetron sputtering (dcMS) and high power pulse magnetron sputtering (HPPMS) PVD were combined by using an industrial coating machine. Hereby, it was possible to deposit dense and smooth triboactive, self-lubricating nitride coatings with different chemical compositions and architectures on 16MnCr5E samples. Two coating architectures, a matrix monolayer and a graded coating structure, were developed to evaluate the effect on the tribological behavior. The morphology and coating thickness were analyzed by means of scanning electron microscopy (SEM). Furthermore, the indentation hardness and modulus of indentation as well as the compound adhesion between substrate materials and coating were analyzed. Tribological analyses of (Cr,Al)N+Mo:S-coated and uncoated samples were conducted under fluid-free friction regime at room temperature T = (20 ± 3) °C, a velocity v = 0.1 m/s and a distance s = 1000 m by varying the Hertzian contact pressure from 400 MPa ≤ pH ≤ 1300 MPa against steel counterparts, 100Cr6, in a pin-on-disk (PoD) tribometer. The graded coating architecture of (Cr,Al)N+Mo:S enabled a significant wear and friction reduction. Furthermore, Raman analyses prove the formation of solid lubrication tribofilm containing MoS2, MoO3 MoO2 and MoxOy at the toplayer of a graded (Cr,Al)N+Mo:S coating, which are responsible for the improved tribological behavior.
Exploration of the temperature-dependent correlations present in the structural, morphological and electrical properties of thermally reduced free-standing graphene oxide papers
Authors: Ramamoorthy Harihara , Buapan Kanokwan , Chiawchan Tinna , Thamkrongart Krongtham , Somphonsane Ratchanok 
Published: July 2021

AbstractWe report on a corroborative study of the structural, morphological and electrical property alterations of free-standing graphene oxide (GO) papers subject to thermal reduction. Structural analysis performed using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Raman techniques prove that the onset of major structural changes, characterized by removal of oxygen functionalities, occur in the 200–300 °C temperature range. The results are corroborated with related morphological changes observed using Scanning electron microscopy (SEM) and Atomic force microscopy (AFM) imaging. Elemental analysis shows the GO paper reduced at 600 °C to contain an 85 wt. % carbon content and a remnant oxygen level of 13.31 wt. %. At the highest reduction temperatures, we see evidence of vacancy-type defects impeding the overall effectiveness of the reduction process. Detailed electrical resistance measurements and current–voltage (I-V) profiling conducted using four-point probe method reveals a several orders of magnitude drop in the sample resistance once the reduction temperature exceeds 200 °C, in good agreement with the structural and morphological changes. The fundamental insights revealed through these studies will be important for future applications where the electrical and mechanical properties of free-standing GO and reduced graphene oxide (rGO) are exploited in practical devices.
Graphical abstract
Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling
Authors: Leohr Jennifer , Kjellsson Maria C. 
Published: July 2021

AbstractThe aim of this work was to develop and evaluate approaches of linked categorical models using individual predictions of probability. A model was developed using data from a study which assessed the perception of sweetness, creaminess, and pleasantness in dairy solutions containing variable concentrations of sugar and fat. Ordered categorical models were used to predict the individual sweetness and creaminess scores and these individual predictions were used as covariates in the model of pleasantness response. The model using individual predictions was compared to a previously developed model using the amount of fat and sugar as covariates driving pleasantness score. The model using the individual prediction of odds of sweetness and creaminess had a lower variability of pleasantness than the model using the content of sugar and fat in the test solutions, which indicates that the individual odds explain part of the variability in pleasantness. Additionally, simultaneous and sequential modeling approaches were compared for the linked categorical model. Parameter estimation was similar, but precision was better with sequential modeling approaches compared to the simultaneous modeling approach. The previous model characterizing the pleasantness response was improved by using individual predictions of sweetness and creaminess rather than the amount of fat and sugar in the solution. The application of this approach provides an advancement within categorical modeling showing how categorical models can be linked to enable the utilization of individual prediction. This approach is aligned with biology of taste sensory which is reflective of the individual perception of sweetness and creaminess, rather than the amount of fat and sugar in the solution.
Earnings management in state-owned enterprises: bringing publicness back in
Authors: Ruggiero Pasquale , Sorrentino Daniela , Mussari Riccardo 
Published: July 2021

AbstractFinancial accountability is a major issue for State-owned Enterprises (SOEs) especially because of the large amount of public resources invested in them and the social relevance of their performance. In the awareness that the public interest is increasingly pursued in abstract arenas, the investigation of accounting should be anchored to conceptual rather than contextual spaces. Building on the dimensional concept of publicness, this paper investigates the impact of three publicness dimensions (ownership, political control, and goal ambiguity) on earnings management (EM) in SOEs, a managerial practice that affects the quality of financial accountability. Drawing on data from a sample of 1200 Italian SOEs, the conditional revenue model (Stubben, 2010) is used to estimate their EM during the period 2009–2017. These EM estimates are then regressed against dimensions of publicness. Findings show that publicness is either neutral or relevant for the quality of SOEs’ financial accountability, depending on the dimensions analysed: while ownership and financial control are positively related to EM in SOEs, administrative control and goal ambiguity are not statistically significant predictors of EM. Moreover, the interaction of publicness dimensions does not affect EM in SOEs. Therefore, this paper shows that SOEs’ publicness is either irrelevant or detrimental to the quality of SOEs’ financial accountability, depending on the dimension of publicness considered. Efforts should be made to define policies and governance arrangements able to influence managers’ behaviour in a way that preserves SOEs’ financial accountability.
Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders
Authors: Sanchez-Aranguren Lissette , Nadeem Sarah 
Published: July 2021

AbstractPregnancy is a challenging physiological process that involves maternal adaptations to the increasing energetics demands imposed by the growing conceptus. Failure to adapt to these requirements may result in serious health complications for the mother and the baby. The mitochondria are biosynthetic and energy-producing organelles supporting the augmented energetic demands of pregnancy. Evidence suggests that placental mitochondria display a dynamic phenotype through gestation. At early stages of pregnancy placental mitochondria are mainly responsible for the generation of metabolic intermediates and reactive oxygen species (ROS), while at later stages of gestation, the placental mitochondria exhibit high rates of oxygen consumption. This review describes the metabolic fingerprint of the placental mitochondria at different stages of pregnancy and summarises key signs of mitochondrial dysfunction in pathological pregnancy conditions, including preeclampsia, gestational diabetes and intrauterine growth restriction (IUGR). So far, the effects of placental-driven metabolic changes governing the metabolic adaptations occurring in different maternal tissues in both, healthy and pathological pregnancies, remain to be uncovered. Understanding the function and molecular aspects of the adaptations occurring in placental and maternal tissue’s mitochondria will unveil potential targets for further therapeutic exploration that could address pregnancy-related disorders. Targeting mitochondrial metabolism is an emerging approach for regulating mitochondrial bioenergetics. This review will also describe the potential therapeutic use of compounds with a recognised effect on mitochondria, for the management of preeclampsia.
Diffusion tractography for awake craniotomy: accuracy and factors affecting specificity
Authors: Voets Natalie L. , Pretorius Pieter , Birch Martin D. , Apostolopoulos Vasileios , Stacey Richard , Plaha Puneet 
Published: July 2021

Abstract
Introduction
Despite evidence of correspondence with intraoperative stimulation, there remains limited data on MRI diffusion tractography (DT)’s sensitivity to predict morbidity after neurosurgical oncology treatment. Our aims were: (1) evaluate DT against subcortical stimulation mapping and performance changes during and after awake neurosurgery; (2) evaluate utility of early post-operative DT to predict recovery from post-surgical deficits.

Methods
We retrospectively reviewed our first 100 awake neurosurgery procedures using DT- neuronavigation. Intra-operative stimulation and performance outcomes were assessed to classify DT predictions for sensitivity and specificity calculations. Post-operative DT data, available in 51 patients, were inspected for tract damage.

Results
91 adult brain tumor patients (mean 49.2 years, 43 women) underwent 100 awake surgeries with subcortical stimulation between 2014 and 2019. Sensitivity and specificity of pre-operative DT predictions were 92.2% and 69.2%, varying among tracts. Post-operative deficits occurred after 41 procedures (39%), but were prolonged (> 3 months) in only 4 patients (4%). Post-operative DT in general confirmed surgical preservation of tracts. Post-operative DT anticipated complete recovery in a patient with supplementary motor area syndrome, and indicated infarct-related damage to corticospinal fibers associated with delayed, partial recovery in a second patient.

Conclusions
Pre-operative DT provided very accurate predictions of the spatial location of tracts in relation to a tumor. As expected, however, the presence of a tract did not inform its functional status, resulting in variable DT specificity among individual tracts. While prolonged deficits were rare, DT in the immediate post-operative period offered additional potential to monitor neurological deficits and anticipate recovery potential.
The effectiveness of antiepileptic drug treatment in glioma patients: lamotrigine versus lacosamide
Authors: van Opijnen Mark P. , van der Meer Pim B. , Dirven Linda , Fiocco Marta , Kouwenhoven Mathilde C. M. , van den Bent Martin J. , Taphoorn Martin J. B. , Koekkoek Johan A. F. 
Published: July 2021

Abstract
Purpose
Optimal treatment with antiepileptic drugs (AEDs) is an important part of care for brain tumor patients with epileptic seizures. Lamotrigine and lacosamide are both examples of frequently used non-enzyme inducing AEDs with limited to no drug-drug interactions, reducing the risk of unfavorable side effects. This study aimed to compare the effectiveness of lamotrigine versus lacosamide.

Methods
In this multicenter study we retrospectively analyzed data of patients with diffuse grade 2–4 glioma with epileptic seizures. All patients received either lamotrigine or lacosamide during the course of their disease after treatment failure of first-line monotherapy with levetiracetam or valproic acid. Primary outcome was the cumulative incidence of treatment failure, from initiation of lamotrigine or lacosamide, with death as competing event, for which a competing risk model was used. Secondary outcomes were uncontrolled seizures after AED initiation and level of toxicity.

Results
We included a total of 139 patients of whom 61 (44%) used lamotrigine and 78 (56%) used lacosamide. At 12 months, there was no statistically significant difference in the cumulative incidence of treatment failure for any reason between lamotrigine and lacosamide: 38% (95%CI 26–51%) versus 30% (95%CI 20–41%), respectively. The adjusted hazard ratio for treatment failure of lacosamide compared to lamotrigine was 0.84 (95%CI 0.46–1.56). The cumulative incidences of treatment failure due to uncontrolled seizures (18% versus 11%) and due to adverse events (17% versus 19%) did not differ significantly between lamotrigine and lacosamide.

Conclusion
Lamotrigine and lacosamide show similar effectiveness in diffuse glioma patients with epilepsy.
Is corruption distasteful or just another cost of doing business?
Authors: Banerjee Ritwik , Boly Amadou , Gillanders Robert 
Published: July 2021

AbstractUsing data from a lab experiment carried out in Kenya, we show that while “legitimate” costs and costs imposed by corruption both deter investment, the latter is no more of a disincentive than the former. We interpret the evidence as consistent with the conclusion that our participants viewed corruption as just another cost of doing business. We also experimented with giving participants in some treatments information about the corruption expectations of participants in previous sessions and the actual extent of corruption in previous sessions. We find some evidence that the objective information actually increased investment without changing the participants’ own expectations regarding corruption. That result is compatible with the idea that revealing the level of corruption changes the descriptive norm and facilitates investment in a corrupt environment.
Metabolic responses of light and taste receptors – unexpected actions of GPCRs in adipocytes
Authors: Ekechukwu Onyinye Nuella , Christian Mark 
Published: July 2021

AbstractThe G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered ‘non-sensory’ such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light and in adipocytes control lipolysis as well as affect brown adipocyte activity. Furthermore, Opsin 3 signals to regulate the conversion of white to thermogenic beige/BRITE (Brown-in-white) adipocytes. Taste receptors that respond to fatty acids, sweet and bitter are expressed in adipocytes as well as in taste buds. Ffar2 and the long chain fatty acid receptor GPR120 are highly expressed in white adipocytes and the human tongue. In adipose tissue Ffar2 mediates the metabolic effects of butyrate and propionate produced by the gut microbiome. GPR120 is highly expressed in brown adipose tissue and regulates fatty acid oxidation and mitochondrial function. The type I taste receptor Tas1r3 senses sweet and umami, is expressed in adipocytes and on obesogenic diets Tas1r3 global gene knockout protects from metabolic dysfunction. Type II taste receptors that sense bitter are expressed by adipocytes and bitter agonists have been found to modulate adipocyte differentiation and lipid storage levels. This review explores recent unexpected findings of light and taste receptors in adipocytes and examines effects of their signaling in the control of adipose tissue biology.
Credible Futures
Authors: Iacona Andrea , Iaquinto Samuele 
Published: July 2021

AbstractThis paper articulates in formal terms a crucial distinction concerning future contingents, the distinction between what is true about the future and what is reasonable to believe about the future. Its key idea is that the branching structures that have been used so far to model truth can be employed to define an epistemic property, credibility, which we take to be closely related to knowledge and assertibility, and which is ultimately reducible to probability. As a result, two kinds of claims about future contingents—one concerning truth, the other concerning credibility—can be smoothly handled within a single semantic framework.
Validation of MATLAB algorithm to implement a two-step parallel pyrolysis model for the prediction of maximum %char yield
Authors: Horsfall Ibiba Taiwo , Ndukwu Macmanus Chinenye , Abam Fidelis Ibiang , Olatunji Ololade Moses , Ojong Ojong Elias , Osa-Aria Keavey 
Published: July 2021

AbstractNumerical modeling of biomass pyrolysis is becoming a cost and time-saving alternative for experimental investigations, also to predict the yield of the by-products of the entire process. In the present study, a two-step parallel kinetic model was used to predict char yield under isothermal condition. MATLAB ODE45 function codes were employed to solve a set of differential equations that predicts the %char at varying residence times and temperatures. The code shows how the various kinetic parameters and mass of pyrolysis products were determined. Nevertheless, the algorithm used for the prediction was validated with experimental data and results from past works. At 673.15 K, the numerical simulation using ODE45 function gives a char yield of 27.84%. From 573.15 K to 673.15 K, char yield ranges from 31.7 to 33.72% to 27.84% while experimental yield decreases from 44 to 22%. Hence, the error between algorithm prediction and experimental data from literature is − 0.26 and 0.22. Again, comparing the result of the present work with the analytical method from the literature showed a good agreement.