bluuebunny/crossref_metadata_2025_split huggingface dataset:
importancia de la música de fondo: comunicación con el cliente
Authors: Loureiro Marlene 
Published: October 2021

Objetivo del estudio: Demostrar cómo la música puede influir en el comportamiento del consumidor de forma positiva, siempre que se planifique para el público objetivo específico del espacio comercial.
Diseño/ Metodología/Enfoque: El entorno de los espacios comerciales presenta algunas variables independientes, como la música, los aromas y los colores, que pueden influir en el comportamiento del consumidor de forma positiva, siempre que se planifiquen para el público específico. En este sentido, la música ambiental puede influir en el comportamiento del consumidor de forma positiva, siempre que esté planificada para el público objetivo específico, ya que los diferentes estímulos musicales del entorno influyen en los individuos, acercándolos o alejándolos. En esta investigación se llevó a cabo un estudio de caso en una superficie comercial, con el fin de comprender si el género musical, así como el tempo de la música influyen realmente en la impresión que los clientes se llevan sobre el ambiente del espacio comercial. Para ello se llevó a cabo la observación participante y se aplicaron encuestas a los clientes de esta superficie comercial.
Resultados: Los resultados muestran que la música puede ayudar a los minoristas a aumentar sus ventas y hacer que su espacio comercial sea más atractivo para su público objetivo.
Limitaciones e implicaciones: A pesar de ser un estudio de caso, se puede demostrar que la música ambiental adecuada puede despertar ciertos estados de ánimo e intenciones de compra en torno a los productos que se venden en el espacio comercial y también que los diferentes géneros musicales cambian la percepción del tiempo que se pasa en ese espacio, contribuyendo a la fidelización de los clientes.
Originalidad/contribución: La música se considera desde hace mucho tiempo un medio eficaz para despertar estados de ánimo y comunicar de forma no verbal. Este artículo explora la importancia de la música asociada al marketing de consumo, como herramienta para cautivar a los clientes en los espacios comerciales.
Making Games for Impact
Authors: Squire Kurt 
Published: October 2021

Designing games for learning: case studies show how to incorporate impact goals, build a team, and work with experts to create an effective game.
Digital games for learning are now commonplace, used in settings that range from K–12 education to advanced medical training. In this book, Kurt Squire examines the ways that games make an impact on learning, investigating how designers and developers incorporate authentic social impact goals, build a team, and work with experts in order to make games that are effective and marketable. Because there is no one design process for making games for impact—specific processes arise in response to local needs and conditions—Squire presents a series of case studies that range from a small, playable game created by a few programmers and an artist to a multimillion-dollar project with funders, outside experts, and external constraints.
These cases, drawn from the Games + Learning + Society Center at the University of Wisconsin–Madison, show designers tackling such key issues as choosing platforms, using data analytics to guide development, and designing for new markets. Although not a how-to guide, the book offers developers, researchers, and students real-world lessons in greenlighting a project, scaling up design teams, game-based assessment, and more. The final chapter examines the commercial development of an impact game in detail, describing the creation of an astronomy game, At Play in the Cosmos, that ships with an introductory college textbook.
Estrogen receptor—positive breast cancer survival prediction and analysis of resistance–related genes introduction
Authors: Shuai Chen , Yuan Fengyan , Liu Yu , Wang Chengchen , Wang Jiansong , He Hongye 
Published: October 2021

Background
In recent years, ER+ and HER2- breast cancer of adjuvant therapy has made great progress, including chemotherapy and endocrine therapy. We found that the responsiveness of breast cancer treatment was related to the prognosis of patients. However, reliable prognostic signatures based on ER+ and HER2- breast cancer and drug resistance-related prognostic markers have not been well confirmed, This study in amied to establish a drug resistance-related gene signature for risk stratification in ER+ and HER2- breast cancer.

Methods
We used the data from The Cancer Genoma Atlas (TCGA) breast cancer dataset and gene expression database (Gene Expression Omnibus, GEO), constructed a risk profile based on four drug resistance-related genes, and developed a nomogram to predict the survival of patients with I-III ER+ and HER2- breast cancer. At the same time, we analyzed the relationship between immune infiltration and the expression of these four genes or risk groups.

Results
Four drug resistance genes (AMIGO2, LGALS3BP, SCUBE2 and WLS) were found to be promising tools for ER+ and HER2- breast cancer risk stratification. Then, the nomogram, which combines genetic characteristics with known risk factors, produced better performance and net benefits in calibration and decision curve analysis. Similar results were validated in three separate GEO cohorts. All of these results showed that the model can be used as a prognostic classifier for clinical decision-making, individual prediction and treatment, as well as follow-up.
Phylogeny ofCrataegus(Rosaceae) based on 257 nuclear loci and chloroplast genomes: evaluating the impact of hybridization
Authors: Liston Aaron , Weitemier Kevin A. , Letelier Lucas , Podani János , Zong Yu , Liu Lang , Dickinson Timothy A. 
Published: October 2021

BackgroundHawthorn species (CrataegusL.; Rosaceae tribe Maleae) form a well-defined clade comprising five subgeneric groups readily distinguished using either molecular or morphological data. While multiple subsidiary groups (taxonomic sections, series) are recognized within some subgenera, the number of and relationships among species in these groups are subject to disagreement. Gametophytic apomixis and polyploidy are prevalent in the genus, and disagreement concerns whether and how apomictic genotypes should be recognized taxonomically. Recent studies suggest that many polyploids arise from hybridization between members of different infrageneric groups.MethodsWe used target capture and high throughput sequencing to obtain nucleotide sequences for 257 nuclear loci and nearly complete chloroplast genomes from a sample of hawthorns representing all five currently recognized subgenera. Our sample is structured to include two examples of intersubgeneric hybrids and their putative diploid and tetraploid parents. We queried the alignment of nuclear loci directly for evidence of hybridization, and compared individual gene trees with each other, and with both the maximum likelihood plastome tree and the nuclear concatenated and multilocus coalescent-based trees. Tree comparisons provided a promising, if challenging (because of the number of comparisons involved) method for visualizing variation in tree topology. We found it useful to deploy comparisons based not only on tree-tree distances but also on a metric of tree-tree concordance that uses extrinsic information about the relatedness of the terminals in comparing tree topologies.ResultsWe obtained well-supported phylogenies from plastome sequences and from a minimum of 244 low copy-number nuclear loci. These are consistent with a previous morphology-based subgeneric classification of the genus. Despite the high heterogeneity of individual gene trees, we corroborate earlier evidence for the importance of hybridization in the evolution ofCrataegus. Hybridization between subgenusAmericanaeand subgenusSanguineaewas documented for the origin ofSanguineaetetraploids, but not for a tetraploidAmericanaespecies. This is also the first application of target capture probes designed with apple genome sequence. We successfully assembled 95% of 257 loci inCrataegus, indicating their potential utility across the genera of the apple tribe.
Effect of Irrigation and Herbicides on Most Tenacious Weed Cyperus rotundus in Wheat
Authors: Lakra Kairovin 
Published: October 2021

To manage the Cyperus rotundus (Purple nut sedge.) is a troublesome, economically damaging weed, widely naturalized in the tropical and subtropical regions of the world. A field experiment was done at Students Instructional Farm of Chandra Shekhar Azad University of Agriculture & Technology, Kanpur (U.P).The study was conducted to investigate the competitive effects of C. rotundus in wheat (Triticum aestivum L.) under varying irrigation regimes and herbicides in field conditions at Kanpur during Rabi 2017-18 and 2018-19 in a split plot design. The experiment was laid out in split-plot design with four irrigation schedule viz. irrigation at CRI and active tillering stage (I1), irrigation at CRI + jointing + booting (I2), CRI + active tillering + booting + flowering stage (I3) and irrigation at CRI + jointing + booting + flowering + milking stage (I4) were assigned to main plots and weed management practices viz. W1-weedy check, W2-two hand weeding at 20 and 40 DAS, W3-sulfosulfuron @25 g/ha , W4- pendimethalin (pre emergence) fbWCPL-15(clodinafop- propargyl 15 %) @400 g/ha , W5- carfentrazone ethyl 20% + sulfosulfuron 25%WG @ 100 g/ha , W6- halauxafen + penxasulam 23.5% @ 75 g/ha , W7- halauxafen - methyl 1.21% w/w + fluroxypyr @ and W8- clodinafop- propargyl 15% + metsulfuron 1% @ 400 g/ha were allocated to sub plots. Application of two irrigations at CRI and active tillering stage (I1) significantly reduced the density of C. rotundus and their fresh and dry weight with highest weed control efficiency (WCE) over irrigation at CRI+ jointing+ booting+ flowering+ milking stage (I4), irrigation at CRI + active tillering + booting + flowering stage (I3) and irrigation at CRI + jointing + booting (I2). However, maximum yield was recorded with the application of five irrigation at CRI+ jointing+ booting+ flowering+ milking stage (I4). Among herbicidal treatments, lowest density, fresh and dry weight of C. rotundus with the highest WCE resulted in higher yield of wheat was recorded with the application of carfentrazone ethyl 20% + sulfosulfuron 25%WG as post emergence (35 DAS) at 100 g/ha as compared to other treatments. However, none of the herbicidal treatments as effective as hand weeding twice at 20 and 40 DAS.
A novel CRT‐IMRT‐combined (Co‐CRIM) planning technique for peripheral lung stereotactic body radiotherapy in pinnacle treatment planning system
Authors: Duan YanHua , Zhou LiJun , Wang Hao , Chen Hua , Gu HengLe , Shao Yan , Feng AiHui , Huang Ying , Fu XiaoLong , Yue Ning Jeff , Ma Kui , Kong Qing , Xu ZhiYong 
Published: October 2021

AbstractObjectivesThis study attempts to explore a novel peripheral lung stereotactic body radiotherapy (SBRT) planning technique that can balance the pros and cons of three‐dimensional conformal radiotherapy (CRT) and intensity‐modulated radiation therapy (IMRT) / volumetric modulated arc therapy (VMAT).MethodsTreatment plans were retrospectively designed based on CRT, IMRT, VMAT, and the proposed CRT‐IMRT‐combined (Co‐CRIM) techniques using Pinnacle treatment planning system (TPS) for 20 peripheral lung cancer patients. Co‐CRIM used an inverse optimization algorithm available in Pinnacle TPS. To develop a Co‐CRIM plan, the number of segments in each field was limited to one, the minimum segment area was set to the internal target volume (ITV), and the minimum monitor units (MU) of the segment was the quotient of fractional dose divided by twice the number of total fields. The performance of Co‐CRIM was then compared with other techniques.ResultsFor conformity index (CI), Co‐CRIM performed comparably to IMRT/VMAT but better than CRT. For gradient index (GI), Co‐CRIM was similar to IMRT/VMAT or CRT. For heterogeneity index (HI), Co‐CRIM was comparable to IMRT/VMAT, higher than CRT. The dosimetric results of spinal cord and lung with Co‐CRIM were better than CRT, comparable to IMRT, but inferior to VMAT. The MU resulted from Co‐CRIM was lower than IMRT/VMAT but higher than CRT. For plan verification γ passing rate, Co‐CRIM was higher than IMRT/VMAT, comparable to CRT. For planning time, Co‐CRIM was shorter than CRT or VMAT but similar to IMRT.ConclusionsThe proposed Co‐CRIM technique on Pinnacle TPS is an effective planning technique for peripheral lung SBRT.
Sheer Frivolous Pleasure: Designing Sensory Stimulation
Authors: Spiller Neil 
Published: October 2021

AbstractDesigning architecture has always been about creating and conducting spatial experiences. Likewise this choreography of space, points of view, vistas and the unfolding of performative narratives through materiality and time are all critical components of entertainment architecture. AD's Editor Neil Spiller explores how the work of STUFISH resonates with and further amplifies familiar themes across architecture's history.
From Nice Ideas to Their Mortal Remains: Pink Floyd at the V&A
Authors: Broackes Victoria 
Published: October 2021

AbstractCurrently Director of the London Design Biennale, Victoria Broackes was previously Senior Curator for the Department of Theatre and Performance at London's Victoria and Albert Museum, where she was instrumental in assembling some of the museum's blockbuster music exhibitions. One of the most visited and iconic was 2017’s ‘Pink Floyd: Their Mortal Remains’. Here she tells its story.
Technology and Audience as Curator: In Conversation with Production Designer Willie Williams
Authors: Lipson Ric 
Published: October 2021

AbstractSTUFISH partner Ric Lipson talks to Willie Williams, who has been a key show director, stage and lighting designer and creative visionary of live entertainment for 40 years. Originally collaborating with STUFISH founder Mark Fisher (then of Fisher Park Partnership) beginning in 1992, the relationship between Williams and the STUFISH studio has created a plethora of innovative stage designs. Here they look forward to see how future audiences might experience such work and how designers need to react to the technological changes that are coming.
Computational Modeling and Experimental Characterization of Extrusion Printing into Suspension Baths
Authors: Prendergast Margaret E. , Burdick Jason A. 
Published: October 2021

AbstractThe extrusion printing of inks into suspension baths is an exciting tool, as it allows the printing of diverse and soft hydrogel inks into 3D space without the need for layer‐by‐layer fabrication. However, this printing process is complex and there have been limited studies to experimentally and computationally characterize the process. In this work, hydrogel inks (i.e., gelatin methacrylamide (GelMA)), suspension baths (i.e., agarose, Carbopol), and the printing process are examined via rheological, computational, and experimental analyses. Rheological data on various hydrogel inks and suspension baths is utilized to develop computational printing simulations based on Carreau constitutive viscosity models of the printing of inks within suspension baths. These results are then compared to experimental outcomes using custom print designs where features such as needle translation speed, defined in this work as print speed, are varied and printed filament resolution is quantified. Results are then used to identify print parameters for the printing of a GelMA ink into a unique guest–host hyaluronic acid suspension bath. This work emphasizes the importance of key rheological properties and print parameters for suspension bath printing and provides a computational model and experimental tools that can be used to inform the selection of print settings.
Enhancing the Kinetic Process in Biphasic Crystalline NiWO4/Amorphous Co‐B Electrode Materials toward Energy Storage with Ultrahigh Rate Performance
Authors: Hou Jing‐Feng , Gao Jian‐Fei , Kong Ling‐Bin 
Published: October 2021

AbstractHere, we report a two‐phase crystalline NiWO4/amorphous Co−B nanocomposite as an electrode material for supercapacitors, which is effectively synthesized via a simple hydrothermal method and chemical precipitation method. The obtained NiWO4/Co−B exhibits crystal‐amorphous contact, which makes it have more active sites than other crystalline‐crystalline phase boundaries, thereby enhancing electron transport. The NiWO4/Co−B electrode with the best mass ratio of crystalline and amorphous exhibits a great specific capacitance and excellent cycle durability. Compared to individual Co−B and NiWO4, it also shows enhanced rate capability Besides, NiWO4/Co−B/activated carbon supercapacitor device can provide a good specific capacitance and a maximum energy density of 10.92 Wh kg−1 at 200 W kg−1. This work provides new insights to develop novel electrode materials for energy storage and conversion.
Effective well management using the J100 framework and methodology
Authors: Güngör‐Demirci Gamze , Keck Jonathan , Lee Juneseok 
Published: October 2021

AbstractWell rehabilitation and replacement are critical functions and activities where water utilities can benefit from rational decision‐support frameworks and tools that enable them to navigate the complex range of technical, managerial, financial, and public/environmental health considerations involved. Based on this industry viewpoint and need, a 15‐variable risk‐based prioritization framework and methodology patterned after the ANSI/AWWA J100 Risk and Resilience Management Standard was therefore developed and tested on a relatively large water system in California. The framework draws from a wide range of information sources and analytical approaches, including existing drinking water source assessments, public documents concerning the health of groundwater basins and aquifers, the results of recently conducted climate change studies, and water distribution modeling to balance the three principal dimensions of the J100 methodology (threat, vulnerability, and consequence). The new tool is expected to help optimize routine monitoring and inspections, as well as enhance the scheduling and implementation of rehabilitation and replacement activities through the deeper and more holistic understanding it provides around regional, site and facility, and water distribution operational and systems engineering factors.
Ein Pilotmarkt der Zukunft – REWE Green Farming
Authors: Mittelstädt Jan , Peter Boris 
Published: October 2021

AbstractDas Pilotkonzept REWE Green Farming, entwickelt durch die Architekten von acme und die Ingenieure von knippershelbig, beschreibt ein Supermarktkonzept der Zukunft – eine Architektur, die einen menschlichen Bezug zu lokal erzeugten Lebensmitteln wiederherstellt und zugleich die Dimension nachhaltigen Bauens mit Holz sichtbar macht. Die Herstellungsprozesse von Lebensmitteln werden für den Nutzer zelebriert. Eine Aquaponikfarm wird in die Marktfunktionen integriert, mit einer Fischanzucht, die sich auf einem Mezzaningeschoss befindet, und dem Anbau von Basilikum in einem Gewächshaus auf der Dachfläche des Markts. Der Markt wurde als Prototyp geplant, mit dessen flexiblem und modularem Bauprinzip die Grundlage für die Übertragung auf weitere Standorte geschaffen wurde. Konstruktiv einfach und materialgerecht, so stellt sich der Tragwerksentwurf für den Holzbau dar. Ein räumliches Holztragwerk aus gestapelten Brettschichtholzbalken dient dem Abtrag der Lasten und wird zugleich prägendes Element der Raumgestaltung und Marktidentität. Die Formgebung der Stützenköpfe und der interne Kraftfluss von den Balkenlagen in die Stützenkonstruktion wurden wesentlich von den Materialeigenschaften des Holzes und reversiblen Fügetechniken beeinflusst. Ziel war es dabei, die Ansprüche der Nutzung, Architektur, Ausführbarkeit und Wirtschaftlichkeit zu beachten und die Ausdruckskraft einer ressourcenschonenden sowie wiederverwendbaren Bauweise in den Fokus zu stellen.
The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma
Authors: Tang Ling‐Long , Chen Yu‐Pei , Chen Chuan‐Ben , Chen Ming‐Yuan , Chen Nian‐Yong , Chen Xiao‐Zhong , Du Xiao‐Jing , Fang Wen‐Feng , Feng Mei , Gao Jin , Han Fei , He Xia , Hu Chao‐Su , Hu De‐sheng , Hu Guang‐Yuan , Jiang Hao , Jiang Wei , Jin Feng , Lang Jin‐Yi , Li Jin‐Gao , Lin Shao‐Jun , Liu Xu , Liu Qiu‐Fang , Ma Lin , Mai Hai‐Qiang , Qin Ji‐Yong , Shen Liang‐Fang , Sun Ying , Wang Pei‐Guo , Wang Ren‐Sheng , Wang Ruo‐Zheng , Wang Xiao‐Shen , Wang Ying , Wu Hui , Xia Yun‐Fei , Xiao Shao‐Wen , Yang Kun‐Yu , Yi Jun‐Lin , Zhu Xiao‐Dong , Ma Jun 
Published: October 2021

AbstractNasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa. To develop these comprehensive guidelines for the diagnosis and management of NPC, the Chinese Society of Clinical Oncology (CSCO) arranged a multi‐disciplinary team comprising of experts from all sub‐specialties of NPC to write, discuss, and revise the guidelines. Based on the findings of evidence‐based medicine in China and abroad, domestic experts have iteratively developed these guidelines to provide proper management of NPC. Overall, the guidelines describe the screening, clinical and pathological diagnosis, staging and risk assessment, therapies, and follow‐up of NPC, which aim to improve the management of NPC.
Design, Synthesis, Cytotoxic Screening and Molecular Docking Studies of Novel Hybrid Thiosemicarbazone Derivatives as Anticancer Agents
Authors: Mohammed Faten Zahran , Rizzk Youstina William , El Deen Ibrahim Mohey , Mourad Ahmed A. E. , El Behery Mohammed 
Published: October 2021

AbstractThiosemicarbazones have been the focus of scientists owing to their broad clinical anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were synthesized and confirmed through the use of different spectroscopic techniques along with elemental analysis. The in vitro cytotoxic activity of compounds 5–9 against MCF‐7 and A549 cell lines and normal breast cells were assessed. Several compounds were found to be active. The most active compound 7 caused MCF‐7 cell cycle arrest at G1/ S phases; and induced apoptosis at the pre‐G1 phase. The apoptosis‐inducing activity of compound 7 was proofed by the elevation of caspase 3/7 activity and also by up‐regulation of the expression of Bax and p53 proteins together with the down‐regulation of the expression of the Bcl‐2 protein. It also had a strong inhibitory effect topoisomerase IIβ enzyme. Molecular Docking study revealed that the synthesized compounds had good docking scores compared to the standard drug Etoposide towards the topoisomerase IIβ protein (3QX3). Overall, these findings confirmed that the new thiosemicarbazone derivatives could aid in the development of promising cancer drug candidates.
Heat and Mass Transfer at the Wall of a Square Mechanically Stirred Gas‐Liquid‐Solid Catalytic Reactor
Authors: Fathalla Ahmed S. , Amin Nevine K. , El-Ashtoukhy El-Sayed Z. , Sedahmed Gomaa H. 
Published: October 2021

AbstractWall mass and heat transfer rates in a square gas‐sparged, mechanically stirred reactor were measured by the electrochemical technique under the effect of various geometrical and hydrodynamic variables. For the 45° impeller, the mass transfer data fit the equation Sh = 0.7Sc0.33Re0.2Reg0.5 with an average deviation of ±6.9 %. For the 90° impeller, the data fit the equation Sh = 0.95Sc0.33Re0.14Reg0.53 with an average deviation of ±7.5 %. Gas sparging enhanced the wall mass transfer rates by factors of up to 2.61 and 3 for the 90° and 45° impellers, respectively, with a significant decrease in the total power consumption. The contribution of the present results to the operation of multiphase mechanically agitated vessels in different aspects is outlined.