bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA MALAT1 and its target microRNA‐125b associate with disease risk, severity, and major adverse cardiovascular event of coronary heart disease
Authors: Lv Fanqin , Liu Liang , Feng Qiang , Yang Xuefeng 
Published: March 2021

AbstractBackgroundThis study aimed to explore the correlation of long non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with microRNA (miR)‐125b and further investigated their associations with disease risk, severity, and prognosis of coronary heart disease (CHD).MethodsTotally, 230 patients who underwent diagnostic coronary angiography were recruited; meanwhile, 140 of them were diagnosed as CHD and the remaining 90 non‐CHD patients served as controls. Plasma sample was collected from each participant for lncRNA MALAT1 and miR‐125b mRNA expression detection by reverse transcription‐quantitative polymerase chain reaction. The extent of coronary stenosis was evaluated by the Gensini score, and major adverse cardiovascular event (MACE) occurrence during the follow‐up was documented in CHD patients.ResultsLong non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1 relative expression was increased, but miR‐125b relative expression was decreased in CHD patients compared with controls. ROC curve exhibited that lncRNA MALAT1 and miR‐125b were of good value in differentiating CHD patients from controls, and further logistic regression analysis verified their independent correlation with CHD risk. Furthermore, lncRNA MALAT1 presented a closely negative correlation with miR‐125b in CHD patients, while it presented a weakly negative association with miR‐125b in controls. In CHD patients, lncRNA MALAT1 was positively correlated with Gensini score, total cholesterol, low‐density lipoprotein cholesterol, C‐reactive protein, tumor necrosis factor α, interleukin (IL)‐1β, IL‐6, IL‐17, and accumulating MACE occurrence; reversely, miR‐125b presented a opposite trend.ConclusionLong non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1 might be associated with increased CHD risk, severity, and accumulating MACE incidence via negative interaction with miR‐125b, suggesting their possible clinical application as biomarkers in the CHD screening and surveillance.
International differences in employee silence motives: Scale validation, prevalence, and relationships with culture characteristics across 33 countries
Authors: Knoll Michael , Götz Martin , Adriasola Elisa , Al‐Atwi Amer Ali , Arenas Alicia , Atitsogbe Kokou A. , Barrett Stephen , Bhattacharjee Anindo , Blanco Norman D. , Bogilović Sabina , Bollmann Grégoire , Bosak Janine , Bulut Cagri , Carter Madeline , Černe Matej , Chui Susanna L. M. , Di Marco Donatella , Duden Gesa S. , Elsey Vicki , Fujimura Makoto , Gatti Paola , Ghislieri Chiara , Giessner Steffen R. , Hino Kenta , Hofmans Joeri , Jønsson Thomas S. , Kazimna Pazambadi , Lowe Kevin B. , Malagón Juliana , Mohebbi Hassan , Montgomery Anthony , Monzani Lucas , Pieterse Anne Nederveen , Ngoma Muhammed , Ozeren Emir , O'Shea Deirdre , Ottsen Christina Lundsgaard , Pickett Jennifer , Rangkuti Anna A. , Retowski Sylwiusz , Ardabili Farzad Sattari , Shaukat Razia , Silva Silvia A. , Šimunić Ana , Steffens Niklas K. , Sultanova Faniya , Szücs Daria , Tavares Susana M. , Tipandjan Arun , van Dick Rolf , Vasiljevic Dimitri , Wong Sut I. , Zacher Hannes 
Published: March 2021

SummaryEmployee silence, the withholding of work‐related ideas, questions, or concerns from someone who could effect change, has been proposed to hamper individual and collective learning as well as the detection of errors and unethical behaviors in many areas of the world. To facilitate cross‐cultural research, we validated an instrument measuring four employee silence motives (i.e., silence based on fear, resignation, prosocial, and selfish motives) in 21 languages. Across 33 countries (N = 8,222) representing diverse cultural clusters, the instrument shows good psychometric properties (i.e., internal reliabilities, factor structure, and measurement invariance). Results further revealed similarities and differences in the prevalence of silence motives between countries, but did not necessarily support cultural stereotypes. To explore the role of culture for silence, we examined relationships of silence motives with the societal practices cultural dimensions from the GLOBE Program. We found relationships between silence motives and power distance, institutional collectivism, and uncertainty avoidance. Overall, the findings suggest that relationships between silence and cultural dimensions are more complex than commonly assumed. We discuss the explanatory power of nations as (cultural) units of analysis, our social scientific approach, the predictive value of cultural dimensions, and opportunities to extend silence research geographically, methodologically, and conceptually.
Successful bronchial arterial infusion chemotherapy combined with radiotherapy for an endobronchial metastasis after resection of small cell lung cancer
Authors: Horio Yoshitsugu , Sato Yozo , Tachibana Hiroyuki , Hosoda Waki , Shimizu Junichi , Hida Toyoaki 
Published: March 2021

AbstractBronchial arterial infusion (BAI) chemotherapy has been reported to be an effective treatment option for centrally located early‐stage squamous cell lung cancer (SCC) and has a favourable response rates for patients with stage III or IV or recurrent non‐small cell lung cancer (NSCLC) without distant metastases who cannot tolerate standard chemotherapy. Here, we report a case of an 83‐year‐old male with a solitary polypoid endobronchial metastatic tumour in the left main bronchus one year and 10 months after video‐assisted thoracoscopic surgery (VATS) combined segmentectomy (left S6 + S8a) for small cell lung cancer (SCLC), pT1bN0. He was treated with BAI of 100 mg of cis‐Diamminedichloroplatinum/cisplatin (CDDP), followed by thoracic radiotherapy (56 Gy in 28 fractions). There was no recurrence for 2.5 years. BAI chemotherapy combined with radiotherapy seemed to be an effective salvage option for the treatment of solitary endobronchial metastases of SCLC in patients unfit for standard chemoradiotherapy.
Inverse probability weighted estimation for recurrent events data with missing category
Authors: Lin Feng‐Chang , Cai Jianwen , Deng Yu , Esther Jr Charles R. 
Published: March 2021

Modeling recurrent event data with multiple event types has drawn interest in recent biomedical studies due to its flexibility for understanding different risk factors for multiple recurrent event processes. However, in such data type, missing event type appears frequently because of various reasons such as recording ignorance or resource limitation. In this study, we aim to propose an inverse probability weighted estimation that is commonly used in the missing data literature to correct possibly biased estimation by a complete‐case analysis. This approach is not limited to a specific form of the recurrent event model. We derive the large sample theory in a general form. We demonstrate that our approach can be applied to either multiplicative or additive rates model with practical sample size via comprehensive simulations. Nonmucoid and mucoid Pseudomonas aeruginosa infections of 14 888 patients in 2016 Cystic Fibrosis Foundation Patient Registry data are analyzed to show that, without including 12% events with missing event type in the analysis, several factors may be misidentified as risk factors for the nonmucoid type of infections.
Anti‐Tubercular Insights of Carbolines – A Decade Critique
Authors: Tewari Upasana , Sharma Divya , Srivastava Shrey , Kumar Banoth Karan , Faheem  , Murugesan Sankaranarayanan 
Published: March 2021

AbstractTuberculosis is one of the top 10 leading causes of death worldwide and is caused by the bacteria “Mycobacterium tuberculosis.” The medications used to treat tuberculosis have many deficiencies, including long‐term treatment, expensive medications, etc. The continuing emergence of multidrug resistance (MTR) remains a critical health issue that needs to be tackled urgently. Increased HIV/AIDS co‐infection with tuberculosis has also worsened the condition. Carbolines, nitrogen‐containing tricyclic Compounds have a significant role in medicinal chemistry because of their broad pharmacological properties, such as anti‐tubercular, anti‐bacterial, anti‐leishmanial, anti‐cancer, anti‐viral, etc. A brief description of the anti‐tubercular ability of a diverse set of carbolines collected from the past ten years focused on synthetic procedures, structural‐activity relationship studies, and their molecular mechanism of action was clearly described in the current review.
Disciplinary Literacies in K–2 Classrooms: A Curriculum Exploration
Authors: Isidro Elizabeth I. 
Published: March 2021

AbstractDisciplinary literacy approaches recently have been finding their way into early elementary classrooms (K‐2) and preschool, but this idea still needs more careful study, discussion, and operationalizing before determining its value and place in the early grades curriculum. The purpose of this article is to describe a case of curriculum exploration by two teachers (using specific texts and developmentally appropriate practice) within an integrated disciplinary literacy–engineering unit and to identify any emerging disciplinary literacy skills among the K‐2 students. The results of this exploration serve as evidence of emerging disciplinary literacy skills among the young learners with teacher scaffolding and developmentally appropriate materials and tasks. Additionally, the study shows concrete literacy outcomes related to comprehension in discussion during and after read‐alouds, as well as particular disciplinary literacy skills based on the engineering design process (i.e., ask, imagine, plan, create, and improve).
Coupled effect of curved surface and interface on stress state of wrinkled thin film coating at the nanoscale
Authors: Kostyrko Sergey , Grekov Mikhail , Altenbach Holm 
Published: March 2021

AbstractIn this paper, we present the model of continuum mechanics for an analysis of the size‐dependent elastic state of the wrinkled thin film coating with the nanosized thickness. For this purpose, we formulate the two‐dimensional boundary value problem for the film‐on‐substrate system under plane strain conditions in terms of the complex variable. To analyse the effect of surface and interface elasticity, the surface and interphase domains are modelled as negligibly thin layers adhering to the bulk phases without slipping. The algorithm of deriving the expressions for the stress tensor components in the first‐order approximation of the boundary perturbation method is described. Based on this algorithm, the influence of the size of the wrinkles, film‐to‐substrate stiffness ratio and film thickness on the stress concentration in the film is examined.
Artifacts and affordances: from designed properties to possibilities for action
Authors: Tollon Fabio 
Published: March 2021

AbstractIn this paper I critically evaluate the value neutrality thesis regarding technology, and find it wanting. I then introduce the various ways in which artifacts can come to influence moral value, and our evaluation of moral situations and actions. Here, following van de Poel and Kroes, I introduce the idea of value sensitive design. Specifically, I show how by virtue of their designed properties, artifacts may come to embody values. Such accounts, however, have several shortcomings. In agreement with Michael Klenk, I raise epistemic and metaphysical issues with respect to designed properties embodying value. The concept of an affordance, borrowed from ecological psychology, provides a more philosophically fruitful grounding to the potential way(s) in which artifacts might embody values. This is due to the way in which it incorporates key insights from perception more generally, and how we go about determining possibilities for action in our environment specifically. The affordance account as it is presented by Klenk, however, is insufficient. I therefore argue that we understand affordances based on whether they are meaningful, and, secondly, that we grade them based on their force.
Risk of Poor Outcomes with COVID-19 Among U.S. Detained Immigrants: A Cross-Sectional Study
Authors: Patler Caitlin , Saadi Altaf 
Published: March 2021

AbstractConditions in immigrant detention centers facilitate the spread of infectious diseases like COVID-19. However, there is no publicly-available data on detainees’ health characteristics, making it difficult to estimate the prevalence of risk among detained people. We use cross-sectional survey data from the only survey of detained immigrants, conducted in California in 2013–2014, to assess the prevalence and health-related correlates of health conditions among detained immigrants. We calculated the proportion of detained immigrants with chronic conditions, their interruptions in care, and stratified by sociodemographic characteristics, evaluating differences using two-tailed tests. Among 529 detained immigrants, 42.5% had at least one chronic health condition; 15.5% had multiple chronic conditions. 20.9% experienced disruption in care upon entering detention. 95.6% had access to stable housing in the U.S. Many detained people face health conditions that confer greater risk for poor outcomes with COVID-19. Stable residence can facilitate release of detainees via Alternatives to Detention programs.
Creating leadership collectives for sustainability transformations
Authors: Care O. , Bernstein M. J. , Chapman M. , Diaz Reviriego I. , Dressler G. , Felipe-Lucia M. R. , Friis C. , Graham S. , Hänke H. , Haider L. J. , Hernández-Morcillo M. , Hoffmann H. , Kernecker M. , Nicol P. , Piñeiro C. , Pitt H. , Schill C. , Seufert V. , Shu K. , Valencia V. , Zaehringer J. G. 
Published: March 2021

AbstractEnduring sustainability challenges requires a new model of collective leadership that embraces critical reflection, inclusivity and care. Leadership collectives can support a move in academia from metrics to merits, from a focus on career to care, and enact a shift from disciplinary to inter- and trans-disciplinary research. Academic organisations need to reorient their training programs, work ethics and reward systems to encourage collective excellence and to allow space for future leaders to develop and enact a radically re-imagined vision of how to lead as a collective with care for people and the planet.
Alternative and additive arthroscopic soft-tissue procedures for anterior shoulder instability
Authors: Trellopoulos Angelos , Brilakis Emmanouil , Antonogiannakis Emmanouil 
Published: March 2021

AbstractAnterior glenohumeral instability is a widespread pathological condition, not only in athletes but also in the general population. The variations in the lesions (soft tissue and bone defects) that occur after traumatic dislocation or recurrence, combined with the degree of ligamentous laxity and activity, have led to numerous surgical techniques. Following the introduction of arthroscopy in the treatment of shoulder pathology, several new procedures and modifications of old methods were introduced to treat anterior instability. Despite this, there is still controversy regarding the proper management of instability cases combined with bone loss or insufficient anterior soft tissue wall or laxity. Additional soft tissue procedures, along with the simple Bankart repair, strengthen the stability of the repair and can fill the gap in the transition from the classic Bankart repair to the potential overtreatment of bony procedures. This literature review attempts to summarize all the critical studies referring to soft tissue techniques and highlight the most crucial points of their conclusions.
A preliminary study on changes in heat shock protein 70 levels induced by Fusarium mycotoxins in rats: in vivo study
Authors: Kócsó Dániel J. , Ali Omeralfaroug , Kovács Melinda , Mézes Miklós , Balogh Krisztián , Kachlek Mariam L. , Bóta Brigitta , Zeebone Yarsmin Y. , Szabó András 
Published: March 2021

AbstractThe heat shock protein (Hsp70) level was assessed after 14 days of oral gavage-exposure to fumonisin B1 (FB1: 150 µg/animal/day), deoxynivalenol (DON: 30 µg/animal/day) and zearalenone (ZEN: 150 µg/animal/day), alone or in combinations (in additive manner: FD = FB1 + DON, FZ = FB1 + ZEN, DZ = DON + ZEN and FDZ = FB1 + DON + ZEN) in the liver, kidneys and lung of 24 adult male Wistar rats (n = 3/group). The liver was the most responsive tissue, as compared with kidney and lung. Except of DZ-treatment, mycotoxins elevated the Hsp70 levels in livers. The highest Hsp70-levels (≈ twofold) were in the DON, FD, FZ and FDZ treatments (additive effects). In the kidney, alterations (↑ ≈ twofold) were detected in ZEN, FD, FZ and DZ treatments. The least responsive organ was the lung (↑ only in FDZ, antagonistic effect). DON and ZEA exposures have altered the reduced glutathione concentration (↓) and glutathione peroxidase activity (↓) in the blood serum. The serum malondialdehyde level increased only after exposure to FD (synergistic effect), as compared with the DZ group (antagonistic effect). When the blood clinical chemistry was assessed, significant alterations were in alanine aminotransferase (80% increase in FDZ, antagonistic effect) and total protein (↓ ZEN). Results varied according to the organ, toxin type and interactions. Furthermore, oxidative stress was not the only key player behind the Hsp70 increase, in which another mechanism is suggested.
Triangles of nearly equal area
Authors: Swanepoel Konrad J. 
Published: March 2021

AbstractGiven anynpoints in the plane, not all on the same line, there exist two non-collinear triples such that the ratio of the areas of the triangles they determine, differs from 1 by at most$$O(\log n/n^2)$$O(logn/n2). If we furthermore insist that the two triangles have a common edge, then there are two with area ratios differing from 1 by at mostO(1/n). This improves some results of Ophir and Pinchasi (Discrete Appl. Math.174(2014), 122–127). We also give some constructions for these and related problems.
Fault diagnosis under uncertain situations within a Bayesian knowledge-intensive CBR system
Authors: Nikpour Hoda , Aamodt Agnar 
Published: March 2021

AbstractThis paper presents fault diagnosis and problem solving under uncertainty by a Bayesian supported knowledge-intensive case-based reasoning (CBR) system called BNCreek. In this system, the main goal is to diagnose the causal failures behind the symptoms in complex and uncertain domains. The system’s architecture is described in three aspects: the general, structural, and functional architectures. The domain knowledge is represented by formally defined methods. An integration of semantic networks, Bayesian networks, and CBR is employed to deal with the domain uncertainty. An experiment is conducted from the oil well drilling domain, which is a complex and uncertain area as an application domain. The system is evaluated against the expert estimations to find the most efficient solutions for the problems. The obtained results reveal the capability of the system in diagnosing causal failures.
Interpreting academic integrity transgressions among learning communities
Authors: Mathrani Anuradha , Han Binglan , Mathrani Sanjay , Jha Meena , Scogings Chris 
Published: March 2021

AbstractEducational institutions rely on academic citizenship behaviors to construct knowledge in a responsible manner. However, they often struggle to contain the unlawful reuse of knowledge (or academic citizenship transgressions) by some learning communities. This study draws upon secondary data from two televised episodes describing contract cheating (or ghostwriting) practices prevalent among international student communities. Against this background, we have investigated emergent teaching and learning structures that have been extended to formal and informal spaces with the use of mediating technologies. Learners’ interactions in formal spaces are influenced by ongoing informal social experiences within a shared cultural context to influence learners’ agency. Building upon existing theories, we have developed an analytical lens to understand the rationale behind cheating behaviors. Citizenship behaviors are based on individual and collective perceptions of what constitutes as acceptable or unacceptable behavior. That is, learners who are low in motivation and are less engaged with learning may collude; more so, if cheating is not condemned by members belonging to their informal social spaces. Our analytical lens describes institutional, cultural, technological, social and behavioral contexts that influence learner agency.
Neurofibromatose Typ 1 – State of the art
Authors: Baumgartner Alicia-Christina , Azizi Amedeo A. 
Published: March 2021

ZusammenfassungNeurofibromatose Typ 1 (NF1) ist ein autosomal dominantes Tumorprädispositionssyndrom, dessen Verlauf nicht vorhersagbar ist und das in Abhängigkeit der Schwere der Symptome vom Kindesalter an eine lebenslange Betreuung durch SpezialistInnen erfordert. Neben harmlosen Hautmanifestationen (u. a. Café-au-lait-Flecken) kann es auch zu Tumoren (Neurofibrome, Optikusgliome, plexiforme Neurofibrome), zu Störungen der Knochenentwicklung, kardiovaskulären sowie endokrinologischen Problemen, aber auch zu Lern- und Entwicklungsstörungen kommen. Aufgrund des heterogenen Verlaufs und der Vielfältigkeit möglicher Symptome kann das Diagnose- und Therapiemanagement herausfordernd sein, wobei ein 2017 gegründetes NF1-Expertisezentrum (in Kooperation zwischen der Patientenorganisation NF-Kinder und der Univ.-Klinik für Kinder- und Jugendheilkunde an der Medizinischen Universität Wien, AKH Wien) Hilfestellung für Betroffene aller Altersstufen im medizinischen wie auch psychosozialen Bereich anbietet.
Lead extraction as metallic phase from waste lead oxide-containing glass by redox reaction in hydrothermal treatment
Authors: Suzuki Masanori , Ukisu Yuma , Murayama Norihiro 
Published: March 2021

AbstractA new low-energy and eco-friendly method for extracting lead from waste PbO-containing funnel glass is required. Conventional methods use either energy intensive smelting reduction at temperatures higher than 1273 K or involve phase separation of the glass, requiring an acid treatment to extract elemental Pb partitioned in one of the decomposed phases as Pb2+ ion. In this study, the mechanism of a unique phenomenon is investigated, involving spontaneous precipitation of metallic lead when PbO-containing glass is subjected to a hydrothermal water environment in a stainless-steel container. The roles of the hydrothermal environment and container materials on the metallic lead precipitation were investigated. The synthesized PbO-containing glass was placed in a container made of stainless steel or pure iron and set in a sealed autoclave with water, which was held at 613 K to provide the hydrothermal conditions. As a result, metallic lead droplets precipitated either on the surface of the glass or the container, whereas an iron oxide (Fe3O4) phase was detected on the surface of the container. Conversely, no metallic lead was observed when the glass and stainless-steel container were heated in dry air. The above results indicate that a hydrothermal environment is necessary for metallic lead precipitation because subcritical water or steam leaches Pb2+ from the glass. In addition, a redox reaction was suggested between the Pb2+ ions transported to the surface of the container and metallic iron in the container to explain metallic lead droplets precipitation.
Exponential Tail Bounds for Chisquared Random Variables
Authors: Ghosh Malay 
Published: March 2021

AbstractThe paper derives some exponential tail bounds for central and non-central chisquared random variables. The bounds are simple and can easily be applied in statistical analysis. Especially relevant are the tail bounds for non-central chisquares, which are different from some of the other exponential bounds available in the literature, for example the one given in [1].