bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloud Microphysical Implications for Marine Cloud Brightening: The Importance of the Seeded Particle Size Distribution
Authors: Hoffmann Fabian , Feingold Graham 
Published: July 2021

AbstractMarine cloud brightening (MCB) has been proposed as a viable way to counteract global warming by artificially increasing the albedo and lifetime of clouds via deliberate seeding of aerosol particles. Stratocumulus decks, which cover wide swaths of Earth’s surface, are considered the primary target for this geoengineering approach. The macroscale properties of this cloud type exhibit a high sensitivity to cloud microphysics, exposing the potential for undesired changes in cloud optical properties in response to MCB. In this study, we apply a highly detailed Lagrangian cloud model, coupled to an idealized parcel model as well as a full three-dimensional large-eddy simulation model, to show that the choice of seeded particle size distribution is crucial to the success of MCB, and that its efficacy can be significantly reduced by undesirable microphysical processes. The presence of even a small number of large particles in the seeded size spectrum may trigger significant precipitation, which will reduce cloud water and may even break up the cloud deck, reducing the scene albedo and hence counteracting MCB. On the other hand, a seeded spectrum comprising a large number of small particles reduces the fraction of activated cloud droplets and increases entrainment and evaporation of cloud water, which also reduces the efficiency of MCB. In between, there may exist an aerosol size distribution that minimizes undesirable microphysical processes and enables optimal MCB. This optimal size distribution is expected to be case dependent.
The Diurnal Cycle of Entrainment and Detrainment in LES of the Southern Ocean Driven by Observed Surface Fluxes and Waves
Authors: Large William G. , Patton Edward G. , Sullivan Peter P. 
Published: July 2021

AbstractEmpirical rules for both entrainment and detrainment are developed from LES of the Southern Ocean boundary layer when the turbulence, stratification, and shear cannot be assumed to be in equilibrium with diurnal variability in surface flux and wave (Stokes drift) forcing. A major consequence is the failure of downgradient eddy viscosity, which becomes more serious with Stokes drift and is overcome by relating the angle between the stress and shear vectors to the orientations of Lagrangian shear to the surface and of local Eulerian shear over 5 m. Thus, the momentum flux can be parameterized as a stress magnitude and this empirical direction. In addition, the response of a deep boundary layer to sufficiently strong diurnal heating includes boundary layer collapse and the subsequent growth of a morning boundary layer, whose depth is empirically related to the time history of the forcing, as are both morning detrainment and afternoon entrainment into weak diurnal stratification. Below the boundary layer, detrainment rules give the maximum buoyancy flux and its depth, as well a specific stress direction. Another rule relates both afternoon and nighttime entrainment depth and buoyancy flux to surface layer turbulent kinetic energy production integrals. These empirical relationships are combined with rules for boundary layer transport to formulate two parameterizations; one based on eddy diffusivity and viscosity profiles and another on flux profiles of buoyancy and of stress magnitude. Evaluations against LES fluxes show the flux profiles to be more representative of the diurnal cycle, especially with Stokes drift.
Indoleamine 2,3 dioxygenase (IDO) level as a marker for significant coronary artery disease
Authors: Wongpraparut Nattawut , Pengchata Ploy , Piyophirapong Sudarat , Panchavinnin Pariya , Pongakasira Rungtiwa , Arechep Noppadol , Kasetsinsombat Kanda , Maneechotesuwan Kittipong 
Published: July 2021

Abstract
Background
Indoleamine 2,3 dioxygenase (IDO), the rate-limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) degradation, is modulated by inflammation, and is regarded as a key molecule driving immunotolerance and immunosuppressive mechanisms. Little is known about IDO activity in patients with active coronary artery disease (CAD).

Methods
We prospectively enrolled patients who were scheduled to undergo coronary angiography. Measurement of IDO, high-sensitivity troponin T (hs-TnT), and high-sensitivity C-reactive protein (hs-CRP) levels was performed at baseline, and IDO activity was monitored at the 6-month follow-up.

Results
Three hundred and five patients were enrolled. Ninety-eight patients (32.1%) presented with recent acute coronary syndrome (ACS). Significant difference in IDO, kynurenine, and hs-TnT between patients with and without significant CAD was observed. Baseline IDO activity, kynurenine level, and hs-TnT level were all significantly higher in significant CAD patients with 3-vessel, 2-vessel, and 1-vessel involvement than in those with insignificant CAD [(0.17, 0.13, and 0.16 vs. 0.03, respectively; p = 0.003), (5.89, 4.58, and 5.24 vs. 2.74 µM/g, respectively; p = 0.011), and (18.27, 12.22, and 12.86 vs. 10.89 mg/dL, respectively; p < 0.001)]. One-year mortality was 3.9%. When we compared between patients who survived and patients who died, we found a significantly lower prevalence of left main (LM) disease by coronary angiogram (6.1% vs. 33.3%, p = 0.007), and also a trend toward higher baseline kynurenine (5.07 vs. 0.79 µM/g, p = 0.082) and higher IDO (0.15 vs. 0.02, p = 0.081) in patients who survived.

Conclusion
Immunometabolic response mediated via IDO function was enhanced in patients with CAD, and correlated with the extent and severity of disease. Patients with LM disease had higher 1-year mortality. Lower level of IDO, as suggested by inadequate IDO response, demonstrated a trend toward predicting 1-year mortality.
Trial registration TCTR Trial registration number TCTR20200626001. Date of registration 26 June 2020. “Retrospectively registered”.
Effect of COVID-19 on epidemiological characteristics of road traffic injuries in Suzhou: a retrospective study
Authors: Huang Wenjuan , Lin Qi , Xu Feng , Chen Du 
Published: July 2021

Abstract
Background
To present the new trends in epidemiology of road traffic injuries (RTIs) during the Coronavirus disease 2019 (COVID-19) pandemic in Suzhou.

Methods
Pre-hospital records of RTIs from January to May in 2020 and the same period in 2019 were obtained from the database of Suzhou pre-hospital emergency center, Jiangsu, China. Data were extracted for analysis, including demographic characteristics, pre-hospital vital signs, transport, shock index, consciousness, pre-hospital death. A retrospective study comparing epidemiological characteristics of RTIs in Suzhou during the 5-month period in 2020 to the parallel period in 2019 was performed.

Results
A total of 7288 RTIs in 2020 and 8869 in 2019 met inclusion criteria. The overall volume of RTIs has statistical difference between the 2 years (p < 0.001), with fewer RTIs in 2020 compared with 2019. Electric bicycle related RTIs increased during the pandemic (2641, 36.24% vs 2380, 26.84%, p < 0.001), with a higher incidence of RTIs with disorder of consciousness (DOC) (7.22% vs 6.13%, p = 0.006).

Conclusions
Under the impact of COVID-19, the total number of RTIs in Suzhou from January to May 2020 decreased. This observation was coupled with a rise in electric bicycle related injuries and an increase in the incidence of RTIs with DOC.
A multiyear systematic survey of the quality of reporting for randomised trials in dentistry, neurology and geriatrics published in journals of Spain and Latin America
Authors: Bachelet Vivienne C. , Navarrete María S. , Barrera-Riquelme Constanza , Carrasco Víctor A. , Dallaserra Matías , Díaz Rubén A. , Ibarra Álvaro A. , Lizana Francisca J. , Meza-Ducaud Nicolás , Saavedra Macarena G. , Tapia-Davegno Camila , Vergara Alonso F. , Villanueva Julio 
Published: July 2021

AbstractBackgroundThe Iberoamerican Cochrane Network is currently developing an extensive project to identify Spanish-language journals that publish original clinical research in Spain and Latin America. The project is called BADERI (Database of Iberoamerican Essays and Journal) and feeds the research articles, mainly randomised clinical trials (RCTs), into CENTRAL (Cochrane Collaboration Central Register of Controlled Trials). This study aims to assess the quality of reporting of RCTs published in Spanish and Latin American journals for three clinical fields and assess changes over time.MethodsWe did a systematic survey with time trend analysis of RCTs for dentistry, geriatrics, and neurology. These fields were chosen for pragmatic reasons as they had not yet been completed in BADERI. After screening RCTs from 1990 to 2018 for randomised or quasi-randomised clinical trials, we extracted data for 23 CONSORT items. The primary outcome was the total score of the 23 predefined CONSORT 2010 items for each RCT (score range from 0 to 34). The secondary outcome measure was the score for each one of these 23 items.ResultsA total of 392 articles from 1990 to 2018 were included as follows: dentistry (282), neurology (80), and geriatrics (30). We found that the overall compliance score for the CONSORT items included in this study for all 392 RCTs analysed was 12.6 on a scale with a maximum score of 34. With time, the quality of reporting improved slightly for all RCTs. None of the articles achieved the complete individual CONSORT item compliance score. The lowest overall compliance percentage was for item 10 (Randomisation implementation) and item 24 (Protocol registration), with a dismal 1% compliance across all included RCTs, regardless of country.ConclusionsCONSORT compliance is very poor in the 392 analysed RCTs. The impact of the CONSORT statement on improving the completeness of RCT reporting in Latin America and Spain is not clear. Iberoamerican journals should become more involved in endorsing and enforcing adherence to the CONSORT guidelines.
Transcriptional landscape of PTEN loss in primary prostate cancer
Authors: Imada Eddie Luidy , Sanchez Diego Fernando , Dinalankara Wikum , Vidotto Thiago , Ebot Ericka M. , Tyekucheva Svitlana , Franco Gloria Regina , Mucci Lorelei Ann , Loda Massimo , Schaeffer Edward Matthew , Lotan Tamara , Marchionni Luigi 
Published: July 2021

AbstractBackgroundPTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have not been described in detail. In this study, we highlight the transcriptional changes associated with PTEN loss in PCa.MethodsUsing a meta-analysis approach, we leveraged two large PCa cohorts with experimentally validated PTEN and ERG status by Immunohistochemistry (IHC), to derive a transcriptomic signature ofPTENloss, while also accounting for potential confounders due toERGrearrangements. This signature was expanded to lncRNAs using the TCGA quantifications from the FC-R2 expression atlas.ResultsThe signatures indicate a strong activation of both innate and adaptive immune systems uponPTENloss, as well as an expected activation of cell-cycle genes. Moreover, we made use of our recently developed FC-R2 expression atlas to expand this signature to include many non-coding RNAs recently annotated by the FANTOM consortium. Highlighting potential novel lncRNAs associated with PTEN loss and PCa progression.ConclusionWe created a PCa specific signature of the transcriptional landscape ofPTENloss that comprises both the coding and an extensive non-coding counterpart, highlighting potential new players in PCa progression. We also show that contrary to what is observed in other cancers, PTEN loss in PCa leads to increased activation of the immune system. These findings can help the development of new biomarkers and help guide therapy choices.
A pilot study of the impact of an integrated individual- and family therapy model for self-harming adolescents on overall healthcare consumption
Authors: Wijana Moa Bråthén , Feldman Inna , Ssegonja Richard , Enebrink Pia , Ghaderi Ata 
Published: July 2021

AbstractBackgroundSelf-harming behaviors in adolescents cause great suffering and can lead to considerable costs to the healthcare system. The aim of the current study was to investigate the cost of an integrated individual and family therapy (Intensive Contextual Treatment: ICT) and to compare the adolescent’s healthcare consumption 1 year before and 1 year after treatment.MethodThe study had a within group design with repeated measures. The clinical outcomes and the cost of ICT treatment are based on a sample of 49 participants who were previously enrolled in an intervention trial. Participants with significantly improved clinical outcomes (self-harm behavior, or general mental health symptoms) were defined as treatment responders. Calculation of changes in healthcare consumption is based on 25 participants who gave their consent to participate in a retrospective collection of healthcare data from medical records, including inpatient and outpatient care, and prescribed medication.ResultsThe average estimated cost of ICT per person was €5293. There were no significant differences between the cost of healthcare consumption 1 year before and after ICT, but the results suggested that the adolescents consumed less inpatient and specialized care after treatment. There was a significantly higher cost of psychotropic medication after treatment explained by a higher consumption of central stimulants. Treatment responders (general mental health problems) reduced their consumption of healthcare resources significantly more than non-responders, especially regarding hospital visits and total health care costs.ConclusionsGood response to the ICT in terms of improved general mental health symptoms seems to be associated with reduced healthcare consumption during the post-treatment period. However, controlled studies with larger sample sizes are needed to draw causal conclusions. The results of this study should be interpreted with caution as it is based on a small sample and attrition rate was high.Trial registrationThis study has been registered with the ISRCTN:15885573.
Increasing obesity odds among foreign-born New Yorkers are not explained by eating out, age at arrival, or duration of residence: results from NYC HANES 2004 and 2013/2014
Authors: Horlyck-Romanovsky Margrethe F. , Haley Sean J. 
Published: July 2021

Abstract
Background
Among the foreign-born in the United States (US) dietary acculturation and eating out may increase obesity risk.
Using the 2004 (N = 1952) and 2013/14 (N = 1481) New York City (NYC) Health and Nutrition Examination Surveys, we compared for the foreign-born and US-born by survey year: 1) odds of obesity; 2) association between eating out and obesity and 3) effect of age at arrival and duration of residence among the foreign-born. Weighted logistic regression estimated odds of obesity.

Results
Compared to the US-born, the foreign-born had lower odds of obesity in 2004, (aOR = 0.51 (95%CI 0.37–0.70), P = <.0001). Odds were no different in 2013/14. In 2013/14 the foreign-born who ate out had lower obesity odds (aOR = 0.49 (95%CI 0.31–0.77), P = 0.0022). The foreign-born living in the US≥10 years had greater odds of obesity in 2004 (aOR = 1.73 (95%CI 1.08–2.79), P = 0.0233) but not in 2013/14.

Conclusions
Eating out does not explain increasing obesity odds among the foreign-born.
Significance of initial, interim and end-of-therapy 18F-FDG PET/CT for predicting transformation risk in follicular lymphoma
Authors: Xie Mixue , Wang Lulu , Jiang Qi , Luo Xuxia , Zhao Xin , Li Xueying , Jin Jie , Ye Xiujin , Zhao Kui 
Published: July 2021

Abstract
Background
Histological transformation (HT) of follicular lymphoma to a more aggressive lymphoma is a serious event affecting patients’ outcomes. To date, no strong clinical HT predictors present at diagnosis have yet been identified. The fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) is highlighted as a non-invasive diagnostic tool for the detection of HT, but its ability to predict HT at early stage of disease has not been clear. Therefore, this study investigated the predictive values of the pre-transformation standardized uptake value (SUVmax) for the risk of transformation in FL.

Methods
This retrospective study involved 219 patients with FL between June 2008 and October 2019 who had undergone 18F-FDG PET/CT scan. One hundred and thirty-two, 64, and 78 patients underwent PET at baseline (PETbaseline), interim (PETinterim) and end-of-induction therapy (PETend), respectively. Qualitative assessment was performed using the 5-point Deauville scale. Statistical analysis was done using Cox regression models, receiver operating characteristic (ROC) analysis, and Kaplan–Meir survival curves.

Results
Of the 219 patients included, 128 had low-grade FL (grade 1–2) and 91 had high-grade FL (grade 3a). HT eventually occurred in 30 patients. The median time to HT was 13.6 months. Among clinical indicators, advance pathological grade was shown as the most significant predictor of HT (HR = 4.561, 95% CI 1.604–12.965). We further assessed the relationship between PET and HT risk in FL. Univariate Cox regression determined that SUVbaseline and SUVend were significant predictors for HT, while neither SUVinterim nor qualitative assessment of Deauville score has predictive value for HT. Due to the noticeable impact of high pathological grade on the HT risk, we conducted the subgroup analysis in patients with low/high pathological grade, and found SUVbaseline could still predict HT risk in both low-grade and high-grade subgroups. Multivariate analysis adjusted by FLIPI2 score showed the SUVbaseline (HR 1.065, 95% CI 1.020–1.111) and SUVend (HR 1.261, 95% CI 1.076–1.478) remained as significant predictors independently of the FLIPI2 score. According to the cut-off determined from the ROC analysis, increased SUVbaseline with a cutoff value of 14.3 and higher SUVend with a cutoff value of 7.3 were highly predictive of a shorter time to HT.

Conclusions
In follicular lymphoma, quantitative assessment used SUVmax at the pre-treatment and end-of-treatment PET/CT scan may be helpful for early screen out patients at high risk of transformation and guide treatment decisions.
Analysis of immune cell components and immune-related gene expression profiles in peripheral blood of patients with type 1 diabetes mellitus
Authors: Lin Jian , Lu Yuanhua , Wang Bizhou , Jiao Ping , Ma Jie 
Published: July 2021

AbstractBackgroundType 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators of β cell destruction. This study attempted to investigate the role of immune cells and immune-related genes in the occurrence and development of T1DM.MethodsThe raw gene expression profile of the samples from 12 T1DM patients and 10 normal controls was obtained from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by Limma package in R. The least absolute shrinkage and selection operator (LASSO)—support vector machines (SVM) were used to screen the hub genes. CIBERSORT algorithm was used to identify the different immune cells in distribution between T1DM and normal samples. Correlation of the hub genes and immune cells was analyzed by Spearman, and gene-GO-BP and gene-pathway interaction networks were constructed by Cytoscape plug-in ClueGO. Receiver operating characteristic (ROC) curves were used to assess diagnostic value of genes in T1DM.ResultsThe 50 immune-related DEGs were obtained between the T1DM and normal samples. Then, the 50 immune-related DEGs were further screened to obtain the 5 hub genes. CIBERSORT analysis revealed that the distribution of plasma cells, resting mast cells, resting NK cells and neutrophils had significant difference between T1DM and normal samples. Natural cytotoxicity triggering receptor 3 (NCR3) was significantly related to the activated NK cells, M0 macrophages, monocytes, resting NK cells, and resting memory CD4+T cells. Moreover, tumor necrosis factor (TNF) was significantly associated with naive B cell and naive CD4+T cell.NCR3[Area under curve (AUC) = 0.918] possessed a higher accuracy thanTNF(AUC = 0.763) in diagnosis of T1DM.ConclusionsThe immune-related genes (NCR3andTNF) and immune cells (NK cells) may play a vital regulatory role in the occurrence and development of T1DM, which possibly provide new ideas and potential targets for the immunotherapy of diabetes mellitus (DM).
Dissecting indirect genetic effects from peers in laboratory mice
Authors: Baud Amelie , Casale Francesco Paolo , Barkley-Levenson Amanda M. , Farhadi Nilgoun , Montillot Charlotte , Yalcin Binnaz , Nicod Jerome , Palmer Abraham A. , Stegle Oliver 
Published: July 2021

AbstractBackgroundThe phenotype of an individual can be affected not only by the individual’s own genotypes, known as direct genetic effects (DGE), but also by genotypes of interacting partners, indirect genetic effects (IGE). IGE have been detected using polygenic models in multiple species, including laboratory mice and humans. However, the underlying mechanisms remain largely unknown. Genome-wide association studies of IGE (igeGWAS) can point to IGE genes, but have not yet been applied to non-familial IGE arising from “peers” and affecting biomedical phenotypes. In addition, the extent to which igeGWAS will identify loci not identified by dgeGWAS remains an open question. Finally, findings from igeGWAS have not been confirmed by experimental manipulation.ResultsWe leverage a dataset of 170 behavioral, physiological, and morphological phenotypes measured in 1812 genetically heterogeneous laboratory mice to study IGE arising between same-sex, adult, unrelated mice housed in the same cage. We develop and apply methods for igeGWAS in this context and identify 24 significant IGE loci for 17 phenotypes (FDR < 10%). We observe no overlap between IGE loci and DGE loci for the same phenotype, which is consistent with the moderate genetic correlations between DGE and IGE for the same phenotype estimated using polygenic models. Finally, we fine-map seven significant IGE loci to individual genes and find supportive evidence in an experiment with a knockout model thatEpha4gives rise to IGE on stress-coping strategy and wound healing.ConclusionsOur results demonstrate the potential for igeGWAS to identify IGE genes and shed light into the mechanisms of peer influence.
We need to bring R0 < 1 to treat cancer too
Authors: Srikrishna Devabhaktuni , Sachsenmeier Kris 
Published: July 2021

AbstractIf each cancer cell produces on average more than one cancer cell, we see a net growth of the tumors and metastases and vice versa. We review recent clinical results for microsatellite stable metastatic colorectal cancer (MSS-mCRC) suggesting immunotherapy combinations with personalized vaccines, checkpoint inhibitors, targeted therapies, multikinase inhibitors, chemotherapies, and radiation that simultaneously slow cancer cell growth rate and enhance T cell killing rate of cancer cells may in future synergize to control the disease.