bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic Stem Cell Transplantation for Relapsed and Refractory Hodgkin Lymphoma: Real World Experience of a Single Center
Authors: Kopińska A. , Koclęga A. , Wieczorkiewicz-Kabut A. , Woźniczka K. , Kata D. , Włodarczyk M. , Helbig G. 
Published: July 2021

Introduction: Refractory and relapsed Hodgkin lymphoma (R/R HL) is associated with poor prognosis, and allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative approach.Aim: The aim of the study was to evaluate the feasibility of allotransplantation in R/R HL setting.Material: Overall, 24 patients (17 men and 7 women) at a median age of 27 years (range 18–44) underwent allo-SCT between 2002 and 2020.Results: Nineteen patients received prior autologous stem cell transplantation (ASCT1) whereas eight patients received second ASCT (ASCT2) after failure of ASCT1. Six patients received only brentuximab vedotin (BV; n = 4) or BV followed by checkpoint inhibitors (CPI; n = 2) before entering allo-SCT. Median time from ASCT1 to allo-SCT was 17.1 months. Fifteen patients received grafts from unrelated donors. Peripheral blood was a source of stem cells for 16 patients. Reduced-intensity conditioning was used for all patients. Disease status at transplant entry was as follows: complete remission (CR; n = 4), partial response (PR; n = 10), and stable disease (SD; n = 10). Acute and chronic graft-versus-host disease (GVHD) developed in 13 (54%) and 4 (16%) patients, respectively. Median follow-up for the entire cohort was 13.3 months. At the last follow-up, 17 (71%) patients died. The main causes of death were disease progression (n = 10), infectious complications (n = 6), and steroid-resistant GVHD (n = 1). Non-relapse mortality at 12 months was 25%. At the last follow-up, seven patients were alive; six patients were in CR, and one had PR. The 2-year overall survival (OS) was 40%.Conclusion: Chemosensitive disease at transplant was associated with better outcome. Allo-SCT allows for long-term survival in refractory and relapsed HL.
Nutritional and Functional Evaluation of Inula crithmoides and Mesembryanthemum nodiflorum Grown in Different Salinities for Human Consumption
Authors: Lima Alexandre R. , Gama Florinda , Castañeda-Loaiza Viana , Costa Camila , Schüler Lisa M. , Santos Tamára , Salazar Miguel , Nunes Carla , Cruz Rui M. S. , Varela João , Barreira Luísa 
Published: July 2021

The nutritional composition and productivity of halophytes is strongly related to the biotic/abiotic stress to which these extremophile salt tolerant plants are subjected during their cultivation cycle. In this study, two commercial halophyte species (Inula crithmoides and Mesembryanthemum nodiflorum) were cultivated at six levels of salinity using a soilless cultivation system. In this way, it was possible to understand the response mechanisms of these halophytes to salt stress. The relative productivity decreased from the salinities of 110 and 200 mmol L−1 upwards for I. crithmoides and M. nodiflorum, respectively. Nonetheless, the nutritional profile for human consumption remained balanced. In general, I. crithmoides vitamin (B1 and B6) contents were significantly higher than those of M. nodiflorum. For both species, β-carotene and lutein were induced by salinity, possibly as a response to oxidative stress. Phenolic compounds were more abundant in plants cultivated at lower salinities, while the antioxidant activity increased as a response to salt stress. Sensory characteristics were evaluated by a panel of culinary chefs showing a preference for plants grown at the salt concentration of 350 mmol L−1. In summary, salinity stress was effective in boosting important nutritional components in these species, and the soilless system promotes the sustainable and safe production of halophyte plants for human consumption.
CO2-Derived Carbon Capture Using Microalgae and Sodium Bicarbonate in a PhotoBioCREC Unit: Kinetic Modeling
Authors: Cordoba-Perez Maureen , de Lasa Hugo 
Published: July 2021

By converting bicarbonates via Chlorella vulgaris photosynthesis, one can obtain valuable biofuel products and find a route toward carbon-derived fossil fuel conversion into renewable carbon. In this research, experiments were carried out in the PhotoBioCREC prototype under controlled radiation and high mixing conditions. Sodium bicarbonate (NaHCO3) was supplied as the inorganic carbon-containing species, at different concentrations, in the 18 to 60 mM range. Both the NaHCO3 concentrations and the organic carbon concentrations were quantified periodically during microalgae culture, with the pH being readjusted every day to the 7.00 level. It was found that sodium bicarbonate was converted with a selectivity up to 33.0% ± 2.0 by Chlorella vulgaris. It was also observed that the reaction rate constant for inorganic carbon conversion was 0.26 ± 0.09 day−1, while the maximum reaction rate constant for organic carbon formation was achieved with a 28 mM NaHCO3 concentration and displayed a 1.18 ± 0.05 mmole L−1day−1 value.
Sentimentos
Authors: De Oliveira Jefferson 
Published: July 2021

O que eutentei fazerconsiste nas cansativas tratativasde tentar te esquecer,no esforço de deslembraro que jamais pode ser esquecidoe assim, abster-me em dizero que não precisou ser dito. Mesmo caminhandocontra meus sentimentosque insistem em lembrarvocê em todos os momentosme criando grande tormento,fomentoe vontadespor causa de um finalque deveria ser dadologo na primeira vez que você fez mal. E deste modo, nossa históriase resumenuma tentativa frustrada.Afinal,esquecer você jamaise ainda digo mais,mesmo com tudo issose o tempo voltasseeu diria améme ainda te aceitariapois até sendo mal você me fazia bem. Faz tempo que a gente não se falamas, minha vontadeé de conversar com você todo diae só pra te encontrar mais uma vezeu seria capazde criar um imprevistocom tudo previstooude causar uma coincidênciaque coincidejustamente com a sua,fazendo questãode esbarrar com você na ruae de cancelar minha agendapra impreterivelmentete sentir, nem que fosse de longenuma feira, na fila de um supermercado,numa cerimônia solenenum cotidiano banalna chuva, no sol,ao vivo, ao vinho, em coresou de modo artificial.
Abordagem qualitativa, pesquisa colaborativa e verdades pravdas sobre ensino de língua portuguesa
Authors: Silva Júnior Silvio Nunes da 
Published: July 2021

A abordagem qualitativa tem seu destaque por ultrapassar a chamada neutralidade do pesquisador e demais limitações da ciência clássica. Tal abordagem adota vertentes que são responsáveis por esclarecer reflexões e ações de pesquisa, assim como a pesquisa colaborativa, que acontece na parceria entre sujeitos da linguagem na produção conjunta de atos responsáveis (BAKHTIN, 2010), os quais são sempre novos e emergidos de situações histórico-sociais distintas. Por essa razão, é inviável, segundo Bakhtin (2012), que se pense numa verdade única, dentro de um círculo fechado. Nessa perspectiva, frente à multiplicidade de vozes e visões propiciada por investigações qualitativas na vertente da pesquisa colaborativa, proponho, com este estudo, uma reflexão sobre a constituição de verdades pravdas sobre ensino de língua portuguesa sob as orientações metodológicas já mencionadas.
Enhancement of optical sectioning capability of temporal focusing microscopy by using time-multiplexed multi-line focusing
Authors: Inazawa Kenta , Isobe Keisuke , Ishikawa Tomohiro , Namiki Kana , Miyawaki Atsushi , Kannari Fumihiko , Midorikawa Katsumi 
Published: July 2021

Abstract
Temporal focusing (TF) microscopy has a trade-off between temporal resolution, optical sectioning capability, and field of view. To improve this trade-off, we demonstrate time-multiplexed multi-line temporal focusing (TM-ML-TF) microscopy, which combines the time-multiplexed TF technique with multi-line focusing using a digital micromirror device. Compared with those for TF microscopy, the optical sectioning capability and the signal-to-background ratio were improved by factors of 2.5 and 4.17, respectively. In addition, by applying post-processing for structured illumination microscopy to TM-ML-TF microscopy, the optical sectioning capability and the signal-to-background ratio were further enhanced by factors of 1.2 and 4.63, respectively.
Ciudades Cambiantes: spazi aperti urbani in evoluzione per nuove città
Authors: Bellmunt Jordi 
Published: July 2021

La città cambia nello stesso modo in cui lo fanno anche le persone. Le vecchie città stanno lottando per la loro sopravvivenza, per il loro futuro, per essere più vivibili, più respirabili, più vicine alle persone che le abitano e, negli ultimi tempi, si stanno rilevando evidenti metamorfosi che rompono schemi, distruggono previsioni e modificano obiettivi pianificati. In un mondo in cui si presume che nei prossimi cinquant'anni oltre l'80% della popolazione vivrà in ambienti urbani, la lotta per rettificare le tendenze e per conquistare la città per il cittadino è cruciale.
Still Life – Natura Morta: the landscapes of proximity
Authors: Dobricic Sasa , Acri Marco 
Published: July 2021

The social distancing does represent an oxymoron: how can there be distancing if what characterizes the very sociality is the proximity between individuals, and generally living beings? Comparable to living dead space (Todd R.W., 2007) or more notorious “still life” or “natura morta”, the paradox remains unsolved: how can something like nature that is impregnated with life, be dead?
PERANCANGAN SIMPLE STATELESS AUTENTIKASI DAN OTORISASI LAYANAN REST-API BERBASIS PROTOKOL HTTP
Authors: Ady Kusuma I Gusti Ngurah 
Published: July 2021

Arsitektur Microservice merupakan arsitektur pembangunan sistem yang sering digunakan saat ini. Konsepnya adalah memisahkan komponen program / fungsionalitas ke dalam aplikasi yang berbeda. Antar komponen menggunakan protokol Hypertext Transfer Protocol (HTTP) untuk berkomunikasi karena HTTP mendukung multiplatform layaknya sebuah website ditambah lagi munculnya skema REST API. REST API memungkinkan pengguna dan layanan untuk bertukar data antar platform. Permasalahan yang muncul berasal dari semua komunikasi pada protokol HTTP bersifat stateless, yang dimana setiap permintaan yang diterima akan dijalankan secara independen. Termasuk apakah klien sebelumnya sudah diautentikasi atau belum. Hal ini akan rentan terhadap penyusup yang belum terotentikasi sehingga tidak dapat dipastikan otoritasnya dalam mengakses suatu fungsi. Berdasarkan permasalahan tersebut, diperlukan skema otentikasi dan otorisasi yang dapat mengakomodasi skema layanan mikro. Metode yang dapat digunakan adalah dengan pemanfaatan kode otorisasi yang bersifat unik yang ditempelkan pada setiap permintaan layanan yang divalidasi oleh sebuah server independent. Alur dari skemanya digambarkan menggunakan sequence diagram dan didukung dengan konseptual database. Penelitian ini menghasilkan sebuah rancangan metode autentikasi dan otorisasi sederhana yang dapat digunakan sebagai alternatif kemanan pada arsitektur microservice
Random Forests as a Viable Method to Select and Discover High-redshift Quasars
Authors: Wenzl Lukas , Schindler Jan-Torge , Fan Xiaohui , Andika Irham Taufik , Bañados Eduardo , Decarli Roberto , Jahnke Knud , Mazzucchelli Chiara , Onoue Masafusa , Venemans Bram P. , Walter Fabian , Yang Jinyi 
Published: July 2021

Abstract
We present a method of selecting quasars up to redshift ≈6 with random forests, a supervised machine-learning method, applied to Pan-STARRS1 and WISE data. We find that, thanks to the increasing set of known quasars, we can assemble a training set that enables supervised machine-learning algorithms to become a competitive alternative to other methods up to this redshift. We present a candidate set for the redshift range 4.8–6.3, which includes the region around z = 5.5 where selecting quasars is difficult due to their photometric similarity to red and brown dwarfs. We demonstrate that, under our survey restrictions, we can reach a high completeness (66% ± 7% below redshift 5.6/

83

−
9

+
6

%

above redshift 5.6) while maintaining a high selection efficiency (

78

−
8

+
10

%

/

94

−
8

+
5

%

). Our selection efficiency is estimated via a novel method based on the different distributions of quasars and contaminants on the sky. The final catalog of 515 candidates includes 225 known quasars. We predict the candidate catalog to contain additional

148

−
33

+
41

new quasars below redshift 5.6 and

45

−
8

+
5

above, and we make the catalog publicly available. Spectroscopic follow-up observations of 37 candidates led us to discover 20 new high redshift quasars (18 at 4.6 ≤ z ≤ 5.5, 2 z ∼ 5.7). These observations are consistent with our predictions on efficiency. We argue that random forests can lead to higher completeness because our candidate set contains a number of objects that would be rejected by common color cuts, including one of the newly discovered redshift 5.7 quasars.
Dynamical Surface Imaging of λ Andromedae
Authors: Martinez Arturo O. , Baron Fabien R. , Monnier John D. , Roettenbacher Rachael M. , Parks J. Robert 
Published: July 2021

Abstract
We present temperature maps of RS CVn star λ Andromedae, reconstructed from interferometric data acquired in 2010 and 2011 by the Michigan Infra-Red Combiner instrument at the Center for High Angular Resolution Astronomy Array. To constrain the stellar parameters required for this imaging task, we first modeled the star using our GPU-accelerated code SImulation and Modeling Tool for Optical Interferometry. The stellar surface was then imaged using our open source interferometric imaging code ROTational Image Reconstruction, in the process further refining the estimation of stellar parameters. We report that the measured angular diameter is 2.742 ± 0.010 mas with a limb-darkening coefficient of 0.231 ± 0.024. While our images are consistent with those of prior works, we provide updated physical parameters for λ Andromedae (R
⋆ = 7.78 ± 0.05 R
⊙, M
⋆ = 1.24 ± 0.72 M
⊙, and log L/L
⊙ = 1.46 ± 0.04).
Can Stochastic Resonance Explain Recurrence of Grand Minima?
Authors: Albert Carlo , Ferriz-Mas Antonio , Gaia Filippo , Ulzega Simone 
Published: July 2021

Abstract
The amplitude of the 11 yr solar cycle is well known to be subject to long-term modulation, including sustained periods of very low activity known as Grand Minima. Stable long-period cycles found in proxies of solar activity have given new momentum to the debate about a possible influence of the tiny planetary tidal forcing. Here, we study the solar cycle by means of a simple zero-dimensional dynamo model, which includes a delay caused by meridional circulation as well as a quenching of the α-effect at toroidal magnetic fields exceeding an upper threshold. Fitting this model to the sunspot record, we find a set of parameters close to the bifurcation point at which two stable oscillatory modes emerge. One mode is a limit cycle resembling normal solar activity including a characteristic kink in the decaying limb of the cycle. The other mode is a weak sub-threshold cycle that could be interpreted as Grand Minimum activity. Adding noise to the model, we show that it exhibits Stochastic Resonance, which means that a weak external modulation can toss the dynamo back and forth between these two modes, whereby the periodicities of the modulation get strongly amplified.
Benthic habitat mapping of Plazh Gradina – Zlatna ribka (Black Sea) and Karpathos and Saria islands (Mediterranean Sea)
Authors: Nikolopoulou Stamatina , Berov Dimitar , Klayn Stefania , Dimitrov Lyubomir , Velkovsky Kiril , Chatzinikolaou Eva , Chatzigeorgiou Giorgos , Karamfilov Ventzislav , Pavloudi Christina 
Published: July 2021

Habitat mapping is nеcessary for the efficient conservation and protection of marine ecosystems. In addition, it is a requirement for EU Member States as stated in the European Union (EU) Habitats Directive (92/43/EEC), as well as necessary for the achievement and maintenance of 'good environmental status (GES)' of benthic marine habitats in the framework of the EU Marine Strategy Framework Directive (2008/56/EC).
This study provides baseline information on the marine benthic habitats of Sozopol Bay (Black Sea) and Karpathos and Saria islands (Mediterranean Sea). These two Natura 2000 sites were selected as study sites of the RECONNECT project, which aimed at creating a transnational cooperative network to confront the environmental threats of ecosystems with a high natural and cultural interest, by the establishment of common practices and a joint regional strategy. The specific objective was to map the marine habitats using a defined a priori classification (EUNIS), with the ultimate purpose of supporting government marine spatial planning, management and decision-making processes through the development of a Decision Support System.
La recherche CCO comme pratique réflexive : une approche relationnelle
Authors: Vézy Camille , Brummans Boris H. J. M. 
Published: July 2021

Comment les recherches CCO peuvent rendre compte de la contribution des chercheur.e.s à la constitution des organisations dans lesquelles ils.elles s’immergent ? Nous proposons une conception relationnelle de la pratique réflexive qui permet à la dimension constitutive de l’organisation de se manifester au fil de l’engagement des chercheur.e.s dans une relation de co-constitution avec l’organisation.
Décoloniser les perspectives CCO : Écouter les voix des traditions critiques latino-américaines en communication
Authors: Vásquez Donoso Consuelo , Marroquín Velásquez Lissette , Guillén Ojeda Griselda 
Published: July 2021

Cet article interroge les approches constitutives de la communication organisationnelle (CCO) en déplaçant le lieu d’énonciation du Nord vers le Sud global, à partir des traditions critiques latino-américaines de la communication (organisationnelle). À cette fin, nous problématisons l’idée de « donner la parole », commune parmi les tendances émergentes en CCO. La relation humain-non humain-nature du Buen Vivir, ainsi que l’agenda de communication pour le changement social, axes d’une théorisation transformatrice, invitent à une posture facilitatrice pour la « prise de la parole » et « l’écoute de la pluralité des voix ».
Histórias da educação brasileira em contextos de ditadura civil-militar
Authors: Zaluski Jorge Luiz 
Published: July 2021

Resenha de:
Gonçalves, N. G., & Bornatto, S. P. (2019). Educação e sociedade na ditadura civil-militar: adesão, acomodações e resistência. Curitiba, PR: CRV.
Identification of vaccine candidate proteins in Ureaplasma urealyticum causing infertility
Authors: Shiragannavar Shilpa Jeevappa , Madagi Shivakumar B. 
Published: July 2021

Background:

Ureaplasma urealyticum has gained resistance to number of antibiotics and has been of the greatest concerns nowadays. The treatment options remain extremely low due to the increased levels of intrinsic resistance gained by the pathogen.

Aim:
The present study focuses on designing a peptide-based vaccine as there is no vaccine available for the pathogen.

Materials and Methods:
All the protein sequences of pathogen were collected and examined using various in silico methods to identify the most immunogenic proteins. The study identifies the proteins which are antigenic in nature which induce the immune response, which lends to quick response of immune system on reinfection. The study describes peptide-based vaccine against U. urealyticum using molecular docking and molecular dynamics simulation approach.

Results:
The study identifies novel putative vaccine candidate proteins that are antigenic, membrane bound and non-allergenic.

Conclusion:
The results of the study imply that the vaccine candidate proteins identified may bring about vigorous enduring defensive immunity against U. urealyticum.
Sex Hormone-Binding Globulins and Testosterone Levels as a Risk Marker for Type 2 Diabetes Mellitus among Postmenopausal Women
Authors: Saikia Uma K. , Jabbar P. K. , Das Darvin V. 
Published: July 2021

Background:
Endogenous sex hormones and sex hormone-binding globulins (SHBG) determine the risk of occurrence of Type 2 diabetes mellitus (T2DM) in postmenopausal (PM) women.

Aims:
To investigate the association between sex hormones (estradiol and testosterone) and SHBG with plasma glucose, fasting insulin levels, HbA1c, and homeostasis model assessment insulin resistance (HOMA-IR) and also to investigate independent role of sex hormones in the occurrence of T2DM among PM.

Settings and Design:
Cross-sectional case–control study.

Subjects and Methods:
The present study was conducted in Endocrinology department Guwahati, Medical College, Assam, India. The participants included cases – PM women with T2DM (n = 100) and controls – Healthy PM women (n = 86). The medical history, clinical examination, and investigations including total testosterone, serum estradiol, SHBG, free testosterone index, high sensitivity C-reactive protein (hs-CRP), lipid profile, fasting insulin, fasting plasma glucose (FPG), and postprandial plasma glucose (PPPG) were done and analyzed. HOMA-IR was calculated.

Statistical Analysis:
Pearson correlation between sex hormone level and SHBG with plasma glucose, HbA1c, fasting insulin, hs-CRP, and HOMA-IR was seen. Multivariance logistic analysis was done to find the independent association between sex hormones/SHBG and the occurrence of T2 DM. P < 0.05 was considered statistically significant.

Results:
Among the cases, a significant positive correlation was found between total testosterone/free testosterone index with waist circumference, FPG PPPG, HbA1c, fasting insulin, and HOMA-IR, and a significant negative correlation was found between SHBG and FPG, PPPG, HbA1c, fasting insulin, and HOMA-IR (P < 0.01). The logistic analysis showed total testosterone levels and SHBG are independently associated with the occurrence of T2 DM among PM (P < 0.01).

Conclusion:
SHBG and testosterone levels in PM can be a risk marker for the development of T2DM.
Pelvic Floor Disorders among Gynecological Cancer Survivors in Sub-urban Regions of Kanchipuram District–India
Authors: Sureshbabu M. Anbupriya , Abirami P. S. 
Published: July 2021

Background:
Pelvic floor muscle is the group of muscles: layering down the pelvic region; Controlling the bowel movements, urination, and sexual intercourse; working in a balanced and coordinated contraction and relaxation. The inability to control the pelvic floor muscles leads to pelvic floor disorders like urinary incontinence, faecal incontinence, dyspareunia, and pelvic pain.

Objective:
The aim of this study is to find the prevalence of pelvic floor disorders among gynaecological cancer survivors in sub-urban regions of Kanchipuram district, India.

Materials and Methods:
This study employs a nonexperimental study design. The procedure is well explained and informed consent is obtained from the gynaecological cancer survivors based on the inclusion and exclusion criteria. Gynecological cancer survivors who are not under any treatments for the last 1 year has been considered for this study. There were two sets of questionnaires in which one depicts vulvar pain function (Vulvar Pain Functional Questionnaire) and the other relates to pelvic floor symptom botheration (Pelvic Floor Bother Questionnaire). The individual has given enough time to fill the questionnaire. Patients seem necessary are further referred to the outpatient physiotherapy department.

Results:
A moderate amount of Pelvic pain was reported to be felt by at least 64.6% of survivors. Added to it, a moderate level of bothersome was found to be reported by at least 56.2 % of survivors.

Conclusion:
Findings conclude that there is a higher prevalence of pelvic floor dysfunction among gynecological cancer survivors.