bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Neoadjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A Population Based Analysis
Authors: Venkat Siv , Lewicki Patrick J. , Basourakos Spyridon P. , Scherr Douglas S. 
Published: September 2021

BACKGROUND AND OBJECTIVES: We examined pathologic complete response (pCR) and pathologic downstaging (pDS) rates after neoadjuvant chemotherapy (NAC) in high-risk upper tract urothelial carcinoma, as well as their predictors. We further sought to determine their effects on overall survival and examine prognosticators of survival after NAC. METHODS: The National Cancer Database was used to identify all patients from 2004 to 2016 with nonmetastatic high grade upper tract urothelial carcinoma who received NAC followed by nephroureterectomy. pCR and pDS rates were examined, and univariate and multivariate logistic regression was performed to identify clinical predictors. Kaplan-Meier and Cox proportional hazard methods were used to estimate overall survival. RESULTS: 309 patients met inclusion criteria. 27 patients (8.74%) had pCR, and 92 (29.77%) had pDS. pCR and pDS rates for N+ subgroup were 6.82% and 47.73% respectively, and for N0 subgroup, 9.50% and 22.62%. Female sex (OR 2.94, p = 0.010) was the only predictor of pCR. Node-positive disease (cN1 vs. cN0: OR 6.40, p < 0.001; cN2 vs. cN0: OR 7.46, p < 0.001) was a positive predictor of pDS, and the presence of lymphovascular invasion (LVI) (OR 0.14, p < 0.001) was a negative predictor of pDS. The median OS for all patients was 45.5 months. pCR and pDS were both associated with improved OS, ( p < 0.001 for both); median was 99.1 months for both. LVI was the strongest negative prognostic factor for OS (HR 2.85, p < 0.001). CONCLUSIONS: Overall pathological complete response and downstaging rates were 8.74% and 29.77% respectively after multi-agent neoadjuvant chemotherapy. Node-negative and node-positive disease had equivalent rates of complete response, but node-positive disease had a significantly higher rate of downstaging. The presence of LVI was associated with worse overall survival.
АЛГЕБРА ПРЕДИКАТІВ ЯК ОСНОВА ЛОГІСТИЧНО-ІНФОРМАЦІЙНИХ МОДЕЛЕЙ У СИСТЕМІ ПІДТРИМКИ ПРИЙНЯТТЯ РІШЕНЬ ЛОГІСТИЧНОГО ЗАБЕЗПЕЧЕННЯ
Authors: Мартинюк Іван , Стаднічук Олена , Петрухін Сергій 
Published: September 2021

У статті розглядається управління процесами, що є складовою логістичного забезпечення ЗС України. Як правило, вони частково структуровані, без чіткої взаємодії з іншими складовими та потребують прийняття складних рішень. Відповідно, на сьогодні розробка математичного забезпечення (моделей, методів, алгоритмів) системи підтримки прийняття рішень у логістичному забезпеченні потреб ЗС України, що враховують відповідні завдання та особливості ведення операцій, є потрібною, а їх впровадження – актуальним завданням. Матеріали статті передбачають можливість удосконалення системи логістичного забезпечення ЗС України шляхом розробки та впровадження логістично-інформаційних моделей системи підтримки прийняття рішень на основі алгебри предикатів. Проаналізовано наукові досягнення у галузі логістики, стан та сучасні погляди на питання логістичного забезпечення збройних сил в Україні та країн-членів НАТО. Запропоновано для розробки логістично-інформаційної моделі системи підтримки прийняття рішень використовувати функціонально-структурний підхід та метод компараторної ідентифікації, що дозволить перейти до єдиної математичної моделі ефективного інформаційного забезпечення особі, що приймає рішення. Рекомендовано застосування багатовимірної моделі зберігання та представлення інформації під час роботи з логістично-інформаційними системами, що дозволить забезпечити визначення всіх ієрархічних складових кожної з підсистем єдиної системи логістики Збройних Сил України. У результаті роботи таких моделей формується раціональний, обґрунтовано визначений вектор логістичного стану до конкретного об'єкта, процесів логістичного забезпечення чи ситуації, що склалась з врахуванням усіх впливів факторів зовнішньої й внутрішньої дії на кожний окремий елемент об’єкта спостереження і надається інформація особам, що приймають рішення. Здійснення інформаційно-аналітичної підтримки особам, які приймають рішення у галузі логістики має відбуватись завдяки наданню таким особам всебічної, необхідної та достатньої інформації для прийняття ефективного управлінського рішення щодо перебігу процесів у системі логістичного забезпечення, впливу внутрішніх і зовнішніх факторів, зворотних зв’язків системи логістично-інформаційних моделей. Представлення даних на основі логістично-інформаційних систем стає перспективним підходом щодо оптимізації управлінського рішення урегулювання відносин між різноплановими процесами логістичного забезпечення.
The Problem-Solution Approach to Study Indonesian Literatures in a Global Context
Authors: Tarigan Karisma Erikson , Stevani Margaret 
Published: September 2021

This study was aimed to describe the problems of learning literature and offered the solutions that were expected to overcome the problems of learning Indonesian literature in schools in a global context. This study used a qualitative approach and contextual methods through a literature study. The results of this study indicated that only through continuous efforts the problems of literary learning could be realized as follows: Students were needed to be guided to know literature in a fun way and instill longing. Students read literary works directly, not summaries or reviews. Students were given the freedom to convey various interpretations in discussing literary works. Every opinion or achievement of student work was given an award. The portion of literary appreciation must be prioritized in literary learning. Knowledge of theory, definition and literary history was sufficient to serve as secondary information when discussing literary works. Reading and writing skills were closely related to learning to appreciate literature. Literary appreciation began with reading activities, while literary expression was related to writing literary works. Thus, literacy development through literary learning in the form of reading habits and writing skills in turn was able to form a strong generation and can compete in a global life that was full of challenges.
Методы моделирования социально-экономических явлений: семиотический и цепочечный анализ
Authors: Shcherbin Vyacheslav K. 
Published: September 2021

Рассматриваются методы семиотического моделирования – семиотический и цепочечный анализ. Определяется релевантность использования указанных методов для изучения социально-экономических явлений. Описываются особенности применения рассматриваемых методов на материале двух групп цепочек: группы коммуникационных, речевых, текстовых цепочек, цепочек мотивов и др.; группы знаниевых, лингвистических, социальных, стоимостных, технологических, философских, экономических и др. Показано, что отличия рассматриваемых методов обусловлены не только тем материалом, для описания которого они используются, но и другими атрибутами: а) различными целями и объектами проводимых с их помощью исследований (целью проведения семиотического анализа явля[1]ется моделирование сложных знаков для более глубокого понимания социально-экономических явлений в целом, представления таких явлений в качестве знаковых систем, кодов, текстов, дискурсов; объектом цепочечного анализа выступают социально-экономические цепочки разных типов, посредством моделирования которых изучаются многообразные социальные и экономические связи); б) ключевыми концептами, составляющими понятийную основу рассматриваемых методов (для семиотического анализа ключевыми являются концепты «код» и «текст»; для цепочечного анализа – концепты «цепная связь» и «цепочка»). Обосновывается вывод о вхождении семиотического и цепочечного анализа наряду с другими методами семиотического моделирования в состав методологического ба[1]зиса новейшего направления социологической науки – социальной семиотики.
Epicardial Transplantation of Autologous Cardiac Micrografts During Coronary Artery Bypass Surgery
Authors: Nummi Annu , Mulari Severi , Stewart Juhani A. , Kivistö Sari , Teittinen Kari , Nieminen Tuomo , Lampinen Milla , Pätilä Tommi , Sintonen Harri , Juvonen Tatu , Kupari Markku , Suojaranta Raili , Kankuri Esko , Harjula Ari , Vento Antti ,   the AADC consortium
Published: September 2021

Background: Cardio-regenerative cell therapies offer additional biologic support to coronary artery bypass surgery (CABG) and are aimed at functionally repairing the myocardium that suffers from or is damaged by ischemia. This non-randomized open-label study assessed the safety and feasibility of epicardial transplantation of atrial appendage micrografts (AAMs) in patients undergoing CABG surgery.Methods: Twelve consecutive patients destined for CABG surgery were included in the study. Six patients received AAMs during their operation and six patients were CABG-operated without AAMs transplantation. Data from 30 elective CABG patients was collected for a center- and time-matched control group. The AAMs were processed during the operation from a biopsy collected from the right atrial appendage. They were delivered epicardially onto the infarct scar site identified in preoperative late gadolinium enhancement cardiac magnetic resonance imaging (CMRI). The primary outcome measures at the 6-month follow-up were (i) patient safety in terms of hemodynamic and cardiac function over time and (ii) feasibility of therapy administration in a clinical setting. Secondary outcome measures were left ventricular wall thickness, change in myocardial scar tissue volume, changes in left ventricular ejection fraction, plasma concentrations of N-terminal pro-B-type natriuretic peptide levels, NYHA class, number of days in hospital and changes in the quality of life.Results: Epicardial transplantation of AAMs was safe and feasible to be performed during CABG surgery. CMRI demonstrated an increase in viable cardiac tissue at the infarct site in patients receiving AAMs treatment.Conclusions and Relevance: Transplantation of AAMs shows good clinical applicability as performed during cardiac surgery, shows initial therapeutic effect on the myocardium and has the potential to serve as a delivery platform for cardiac gene therapies.Trial Registration:ClinicalTrials.gov, identifier: NCT02672163.
LncRNA PVT1 Knockdown Ameliorates Myocardial Ischemia Reperfusion Damage via Suppressing Gasdermin D-Mediated Pyroptosis in Cardiomyocytes
Authors: Li Cuizhi , Song Huafeng , Chen Chunlin , Chen Shaoxian , Zhang Qiyu , Liu Dehui , Li Jinglong , Dong Haojian , Wu Yueheng , Liu Youbin 
Published: September 2021

Objective: Myocardial ischemia reperfusion (I/R) damage is a life-threatening vascular emergency after myocardial infarction. Here, we observed the cardioprotective effect of long non-coding RNA (lncRNA) PVT1 knockdown against myocardial I/R damage.Methods: This study constructed a myocardial I/R-induced mouse model and a hypoxia/reoxygenation (H/R)-treated H9C2 cells. PVT1 expression was examined via RT-qPCR. After silencing PVT1 via shRNA against PVT1, H&amp;E, and Masson staining was performed to observe myocardial I/R damage. Indicators of myocardial injury including cTnI, LDH, BNP, and CK-MB were examined by ELISA. Inflammatory factors (TNF-α, IL-1β, and IL-6), Gasdermin D (GSDMD), and Caspase1 were detected via RT-qPCR, western blot, immunohistochemistry, or immunofluorescence. Furthermore, CCK-8 and flow cytometry were presented for detecting cell viability and apoptosis.Results: LncRNA PVT1 was markedly up-regulated in myocardial I/R tissue specimens as well as H/R-induced H9C2 cells. Silencing PVT1 significantly lowered serum levels of cTnI, LDH, BNP, and CK-MB in myocardial I/R mice. H&amp;E and Masson staining showed that silencing PVT1 alleviated myocardial I/R injury. PVT1 knockdown significantly lowered the production and release of inflammatory factors as well as inhibited the expression of GSDMD-N and Caspase1 in myocardial I/R tissue specimens as well as H/R-induced H9C2 cells. Moreover, silencing PVT1 facilitated cell viability and induced apoptosis of H/R-treated H9C2 cells.Conclusion: Our findings demonstrated that silencing PVT1 could alleviate myocardial I/R damage through suppressing GSDMD-mediated pyroptosis in vivo and in vitro. Thus, PVT1 knockdown may offer an alternative therapeutic strategy against myocardial I/R damage.
An Assessment of Recently Released High-Degree Global Geopotential Models Based on Heterogeneous Geodetic and Ocean Data
Authors: Wu Yihao , He Xiufeng , Luo Zhicai , Shi Hongkai 
Published: September 2021

The development of the global geopotential model (GGM) broadens its applications in ocean science, which emphasizes the importance for model assessment. We assess the recently released high-degree GGMs over the South China Sea through heterogeneous geodetic observations and synthetic/ocean reanalysis data. The comparisons with a high resolution (∼3 km) airborne gravimetric survey over the Paracel Islands show that XGM2019e_2159 has relatively high quality, where the standard deviation (SD) of the misfits against the airborne gravity data is ∼3.1 mGal. However, the comparisons with local airborne/shipborne gravity data hardly discriminate the qualities of other GGMs that have or truncated to the same expansion degree. Whereas, the comparisons with the synthetic/ocean reanalysis data demonstrate that the qualities of the values derived from different GGMs are not identical, and the ones derived from XGM2019e_2159 have better performances. The SD of the misfits between the mean dynamic topography (MDT) derived from XGM2019e_2159 and the ocean data is 2.5 cm; and this value changes to 7.1 cm/s (6.8 cm/s) when the associated zonal (meridian) geostrophic velocities are assessed. In contrast, the values derived from the other GGMs show deteriorated qualities compared to those derived from XGM2019e_2159. In particular, the contents computed from the widely used EGM2008 have relatively poor qualities, which is reduced by 3.9 cm when the MDT is assessed, and by 4.0 cm/s (5.5 cm/s) when the zonal (meridian) velocities are assessed, compared to the results derived from XGM2019e_2159. The results suggest that the choice of a GGM in oceanographic study is crucial, especially over coastal zones. Moreover, the synthetic/ocean data sets may be served as additional data sources for global/regional gravity field assessment, which are useful in regions that lack of high-quality geodetic data.
Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients
Authors: Ran Zijing , Xue Xiaomei , Han Lin , Terkeltaub Robert , Merriman Tony R. , Zhao Ting , He Yuwei , Wang Can , Li Xinde , Liu Zhen , Cui Lingling , Li Hailong , Ji Aichang , Hu Shuhui , Lu Jie , Li Changgui 
Published: September 2021

ObjectiveTo clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout.MethodsWe retrospectively analyzed 237 male gout patients who had two sets of body composition and metabolic measurements within 6 months. Subjects included had all been treated with urate-lowering therapy (ULT) (febuxostat 20–80 mg/day or benzbromarone 25–50 mg/day, validated by the medical record). All patients were from the specialty gout clinic of The Affiliated Hospital of Qingdao University. The multiple linear regression model evaluated the relationship between change in SU [ΔSU, (baseline SU) – (final visit SU)] and change in VFA [ΔVFA, (baseline VFA) – (final visit VFA)].ResultsULT resulted in a mean (standard deviation) decrease in SU level (464.22 ± 110.21 μmol/L at baseline, 360.93 ± 91.66 μmol/L at the final visit, p &lt;0.001) accompanied by a decrease in median (interquartile range) VFA [97.30 (81.15–118.55) at baseline, 90.90 (75.85–110.05) at the final visit, p &lt; 0.001]. By multiple regression model, ΔSU was identified to be a significant determinant variable of decrease in VFA (beta, 0.302; p = 0.001).ConclusionsThe decrease in SU level is positively associated with reduced VFA. This finding provides a rationale for clinical trials to affirm whether ULT promotes loss of visceral fat in patients with gout.
Study on the Residual Stress Relieving Mechanism of C/C Composite-Nb Brazed Joint by Employing a Structurally Optimized Graphene Reinforced Cu Foam Interlayer
Authors: Li Hongliang , Wang Zeyu , Butt Hassaan Ahmad , Ye Maocheng , Chen Hao , Zhao Tianmo , Li Manni , Ma Qiang , Lei Yucheng 
Published: September 2021

Cu foam has previously been investigated and verified to be an excellent interlayer candidate for relieving high residual stress within C/C composite-Nb brazed joints. However, the optimized geometric structure of Cu foam for brazing has never been properly investigated since it was always employed as a reactant for acquiring homogeneous distribution of the interfacial structures in the brazed joints. In this work, graphene reinforced Cu foam composite (G-Cuf) interlayers were used for brazing C/C composite and Nb. Through the protection effect of graphene on the Cu foam substrate, the impact of porosity and thickness of a structurally intact Cu foam on the joint structure and properties were investigated by finite elemental analysis as well as through experimental studies. By introducing a G-Cuf interlayer with an optimized porosity of 90% and thickness of 0.15 mm, the shear strength of the C/C composite-Nb brazed joint reached 45 MPa, which is 3.5 times higher than that of the joint brazed directly without an interlayer. The strain energy of the brazed joint assisted by G-Cuf interlayer reduced from as high as 10.98 × 10–6 J to 6.90 × 10–6 J, suggesting that the residual stress was effectively mitigated.
Hospital Admission to a Window-Side Bed Does Not Prevent Delirium: A Retrospective Cohort Study of Older Medical Inpatients in General Wards
Authors: Aomura Daiki , Yamada Yosuke , Harada Makoto , Hashimoto Koji , Kamijo Yuji 
Published: September 2021

Background:Delirium in older inpatients is a serious problem. The presence of a window in the intensive care unit has been reported to improve delirium. However, no study has investigated whether window-side bed placement is also effective for delirium prevention in a general ward.Objectives:This study aims to clarify the association between admission to a window-side bed and delirium development in older patients in a general ward.Design:This research is designed as a retrospective cohort study of older patients admitted to the internal medicine departments of Shinshu University Hospital, Japan.Participants:The inclusion criteria were the following: (1) admitted to hospital internal medicine departments between April 2009 and December 2018, (2) older than 75 years, (3) admitted to a multi-patient room in a general ward, and (4) unplanned admission. The number of eligible patients was 1,556.Exposure:This study is a comparison of 495 patients assigned to a window-side bed (window group) with 1,061 patients assigned to a non-window-side bed (non-window group). When patients were transferred to the other type bed after admission, observation was censored.Main Measures:The main outcome of interest was “delirium with event” (e.g., the use of medication or physical restraint for delirium) within 14 days after admission as surveyed by medical chart review in a blinded manner.Key Results:The patients had a median age of 80 years and 38.1% were female. The main outcome was recorded in 36 patients in the window group (10.7 per thousand person-days) and 84 in the non-window group (11.7 per thousand person-days). Log-rank testing showed no significant difference between the groups (p= 0.78). Multivariate analysis with Cox regression modeling also revealed no significant association for the window group with main outcome development (adjusted hazard ratio 0.90, 95% confidence interval of 0.61–1.34).Conclusions:Admission to a window-side bed did not prevent delirium development in older patients admitted to a general ward.
First Experience of Three Neurovascular Centers With the p64MW-HPC, a Low-Profile Flow Diverter Designed for Proximal Cerebral Vessels With Antithrombotic Coating
Authors: Winters Helge , Schüngel Marie-Sophie , Scherlach Cordula , Mucha Dirk , Thalwitzer Jörg , Härtig Wolfgang , Donitza Aneta , Bailis Nikolaos , Maybaum Jens , Hoffmann Karl Titus , Quäschling Ulf , Schob Stefan 
Published: September 2021

Background: In the last decade, flow diversion (FD) has been established as hemodynamic treatment for cerebral aneurysms arising from proximal and distal cerebral arteries. However, two significant limitations remain—the need for 0.027” microcatheters required for delivery of most flow diverting stents (FDS), and long-term dual anti-platelet therapy (DAPT) in order to prevent FDS-associated thromboembolism, at the cost of increasing the risk for hemorrhage. This study reports the experience of three neurovascular centers with the p64MW-HPC, a FDS with anti-thrombotic coating that is implantable via a 0.021” microcatheter.Materials and methods: Three neurovascular centers contributed to this retrospective analysis of patients that had been treated with the p64MW-HPC between March 2020 and March 2021. Clinical data, aneurysm characteristics, and follow-up results, including procedural and post-procedural complications, were recorded. The hemodynamic effect was assessed using the O'Kelly–Marotta Scale (OKM).Results: Thirty-two patients (22 female, mean age 57.1 years) with 33 aneurysms (27 anterior circulation and six posterior circulation) were successfully treated with the p64MW-HPC. In 30/32 patients (93.75%), aneurysmal perfusion was significantly reduced immediately post implantation. Follow-up imaging was available for 23 aneurysms. Delayed aneurysm perfusion (OKM A3: 8.7%), reduction in aneurysm size (OKM B1-3: 26.1%), or sufficient separation from the parent vessel (OKM C1-3 and D1: 65.2%) was demonstrated at the last available follow-up after a mean of 5.9 months. In two cases, device thrombosis after early discontinuation of DAPT occurred. One delayed rupture caused a caroticocavernous fistula. The complications were treated sufficiently and all patients recovered without permanent significant morbidity.Conclusion: Treatment with the p64MW-HPC is safe and feasible and achieves good early aneurysm occlusion rates in the proximal intracranial circulation, which are comparable to those of well-established FDS. Sudden interruption of DAPT in the early post-interventional phase can cause in-stent thrombosis despite the HPC surface modification. Deliverability via the 0.021” microcatheter facilitates treatment in challenging vascular anatomies.