bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro‐inflammatory profiles in cardiovascular disease patients with peri‐implantitis
Authors: Wang I‐Ching , Sugai Jim V. , Majzoub Jad , Johnston Jeffery , Giannobile William V. , Wang Hom‐Lay 
Published: November 2021

AbstractBackgroundTo investigate the pro‐inflammatory cytokine profiles in patients with or without cardiovascular disease (CVD) and with or without peri‐implantitis.MethodsSerum, peri‐implant crevicular fluid (PICF), and gingival crevicular fluid (GCF) were collected from patients with (n = 82) or without CVD (n = 46) at the most severe peri‐implantitis site including sites with periodontitis. A panel of proinflammatory molecules including high‐sensitivity C‐reactive protein (hsCRP), fibrinogen, interleukin‐1 beta (IL‐1β), IL‐6, plasma tumor necrosis factor‐alpha (TNF‐α), matrix metallo‐proteinase‐8 (MMP‐8), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF), IL‐17, IL‐8, tissue inhibitor of metalloproteinase‐2 (TIMP‐2), myeloperoxidase (MPO), and prostaglandin E2 (PGE2) were analyzed using human custom Quantibody arrays. Krunskal‐Wallis test was used to compare groups. The diagnostic ability of each biomarker was assessed using chi‐square test and ROC analysis.ResultsSerum IL‐1β, TNF‐α and fibrinogen were significantly higher in CVD patients than those without. Serum fibrinogen displayed a trend of higher concentration in patients with radiographic bone loss (RBL) ≥2 mm (P = 0.08). PICF TNF‐α exhibited a significantly higher detection level in the CVD patients that is coincided with the local peri‐implant inflammation. In addition, PICF MMP‐8 was significantly higher in the RBL ≥2 mm sites than the healthy implants; whereas IL‐1β, IL‐8, MMP‐8, and TIMP‐2 proved to be the significant predictors for peri‐implant disease. GCF TNF‐α collected from patients with periodontitis was significantly associated with CVD cases.ConclusionThe augmented expression of local and systemic pro‐inflammatory cytokines found in the current study supports the weak association between the chronic peri‐implantitis with increasing severity and CVD.
Outcome of Extended Right Lobe Liver Transplantations
Authors: Lozanovski Vladimir J. , Unterrainer Christian , Döhler Bernd , Süsal Caner , Mehrabi Arianeb 
Published: November 2021

Split‐liver transplantation offers a solution to the organ shortage problem. However, the outcomes of extended right lobe liver transplantation (ERLT) and whether it is a suitable alternative to full‐size liver transplantation (FSLT) remain controversial. We compared the outcomes of ERLT and FSLT in adult recipients of 43,409 first deceased donor liver transplantations using Cox regression. We also analyzed 612 ERLT and 1224 FSLT 1:2 matched cases to identify factors that affect ERLT outcome. The risk of graft loss was significantly higher following ERLT than following FSLT during the first posttransplantation year in the matched and unmatched collective (hazard ratio [HR], 1.39 and 1.27 and P = 0.01 and 0.006, respectively). Every additional hour of cold ischemia time (CIT) increased the risk of 1‐year graft loss by 10% in the ERLT group compared with only 3% in the FSLT group (P = 0.003 and <0.001, respectively). Importantly, the outcome of ERLT and FSLT did not differ significantly if the CIT was below 10 hours (HR, 0.71; P = 0.22). One‐year graft and patient survival were lower in high‐risk ERLT recipients with a Model for End‐Stage Liver Disease (MELD) score of ≥20 (HR, 1.88; P = 0.03 and HR, 2.03; P = 0.02). In the male recipient–male donor combination, ERLT recipients had a higher risk of 1‐year graft loss than FSLT recipients (HR, 2.44; P = 0.006). This was probably because of the significantly higher MELD score in ERLT recipients (P = 0.004). ERLT in adults is an adequate alternative to FSLT and offers an elegant solution to the problem of organ shortage as long as the cold storage is less than 10 hours and the recipient’s MELD score is <20.
Fog probabilistic forecasting using an ensemble prediction system at six airports in Iran for 10 fog events
Authors: Pahlavan R. , Moradi M. , Tajbakhsh S. , Azadi M. , Rahnama M. 
Published: November 2021

AbstractLow visibility conditions due to fog affect air traffic and, in some cases, are the leading cause of aviation accidents. Accurate forecasting of fog can lead to a significant reduction of human and financial losses. Numerical weather prediction (NWP) models have limitations in simulating fog accurately for operational purposes. However, recent studies have confirmed that ensemble‐based forecasts are effective in fog forecasting. In this study, a multi‐physics ensemble prediction system (EPS) was used to simulate the occurrence of several radiation, cloud base lowering (CBL), and advection fog events that occurred at Arak, Ardebil, Hamedan, Orumiyeh, Rasht and Shahrekord airports located across Iran, during January and December 2015. The multi‐physics EPS including a reference deterministic forecast consists of 16 different configurations of the weather research and forecasting (WRF) model and was run from 12 UTC 12 January to 12 UTC 16 January 2015 and from 00 UTC 27 December to 12 UTC 31 December 2015 to simulate fog occurrences at six airports. SW99 and G2009 visibility algorithms were applied to the EPS outputs to predict the fog. The advantages of probabilistic fog forecasting in this study were shown by comparing the reference forecast and the ensemble‐based forecasts of fog events. The results showed that by considering a probability threshold of 37.5%, 50% and 62.5% for the ensemble forecasts, the EPS outperformed the deterministic fog forecasts obtained from a deterministic reference forecast. Such that, with 37.5% and 50% probability thresholds, the equitable threat score (ETS) was much higher than the ETS for the reference deterministic fog forecast. Also, the EPS with 37.5% and 50% probability thresholds could correctly predict 3 and 4 (out of 10) more fog events compared with the reference deterministic forecast.
Geometric analysis of the urethral‐vaginal interface curvature in women with and without stress urinary incontinence: A pilot magnetic resonance imaging study
Authors: Hong Christopher X. , Sheyn David D. , Sammarco Anne G. , DeLancey John O. 
Published: November 2021

AbstractAimsTo evaluate differences in the curvature of the urethral‐vaginal interface in women with and without stress urinary incontinence (SUI) using geometric morphometric analysis techniques.MethodsWe conducted a pilot case–control study using magnetic resonance imaging (MRI) scans of 18 women with and without SUI. The urethral‐vaginal interface at the level of the mid‐urethra was fitted with a second‐order polynomial regression. The chord length and chord‐to‐vertex length of the resulting parabolic curve were used to calculate the arc length and radius of a circular arc fitted to the interface curvature. Demographic characteristics and Pelvic Organ Prolapse Quantification (POP‐Q) parameters were collected. Subjects were stratified by those with and without SUI, as well as by those with and without anterior wall prolapse beyond 2 cm proximal to the hymen (Aa > −2 cm).ResultsThe radius of the urethral‐vaginal interface curvature was not found to be different between subjects with and without SUI (8.8 vs. 9.2 mm, p = 0.53); however, this value was smaller in subjects with Aa > −2 (8.4 vs. 11.9 mm, p = 0.03). The chord length, chord‐to‐vertex length, and arc length comprising the urethral‐vaginal interface curvature were similar between subjects with and without SUI, and between subjects with and without Aa > −2 cm (p > 0.05 for all).ConclusionsIn this pilot study population, the radius of the urethral‐vaginal interface curvature at the mid‐urethra was smaller among women with anterior vaginal wall prolapse beyond 2 cm proximal to the hymen. A difference in the urethral‐vaginal interface curvature among women with and without SUI was not found.
Clinical Impact of GLP‐1 receptor agonists in veterans receiving basal‐bolus insulin
Authors: Hopton Olivia M. , Waterbury Nancee V. , Egge Jason A. , Lund Brian C. 
Published: November 2021

AbstractBackgroundIn 2017, an estimated 7.4 million Americans used insulin to treat diabetes. Insulin is proven to lower A1c but can result in hypoglycemia and weight gain. Combining insulin with a glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) may provide additional blood glucose control while limiting undesirable effects including weight gain.ObjectiveTo characterize the clinical impact of adding a GLP‐1‐RA to a basal‐bolus insulin regimen in patients with type 2 diabetes.MethodsThis retrospective observational study used national Veteran's Health Administration data to identify patients with an existing basal‐bolus insulin regimen who initiated a GLP‐1‐RA between January 1, 2005 and December 31, 2017. A1c, insulin total daily dose (TDD), and weight were collected at GLP‐1‐RA initiation (baseline), 3‐, 6‐, and 12‐month time points and then analyzed using an intent‐to‐treat approach with the last observation carried forward. Decreases in A1c ≥ 0.5% and weight ≥2 kg were deemed clinically significant.ResultsAmong 7651 patients initiating GLP‐1‐RA therapy, mean A1c had a clinically significant decline at 3, 6, and 12 months by −0.5%, −0.7%, and −0.7%, respectively, from a mean baseline of 9%. Patients with lower baseline A1c levels did not have clinically significant changes in A1c, whereas patients with baseline A1c ≥9% had more clinically significant declines. Insulin TDD decreased by −32, −38, and −42 units/day at 3, 6, and 12 months, respectively, where the mean decrease in insulin TDD at 12 months was 79 units/day among patients who discontinued bolus insulin (52.3%) compared with a mean decrease of 2 units/day among those who continued bolus insulin. Mean weight reductions at 3, 6, and 12 months were −1.2, −2.3, and −2.9 kg, respectively, from a mean baseline of 120.6 kg.ConclusionCombining a GLP‐1‐RA with basal‐bolus insulin had a clinically significant improvement on blood glucose control, lowered insulin TDD, and reduced weight. These outcomes were achieved within 3 to 6 months following GLP‐1‐RA initiation and were maintained through 1 year.
Concordance of biopsy and pathologic ISUP grading in salvage radical prostatectomy patients for recurrent prostate cancer
Authors: Preisser Felix , Würnschimmel Christoph , Pose Randi M. , Heinze Alexander , Steuber Thomas , Michl Uwe , Salomon Georg , Mandel Philipp , Graefen Markus , Tilki Derya 
Published: November 2021

AbstractPurposeTo investigate the concordance of biopsy and pathologic International Society of Urological Pathology (ISUP) grading in salvage radical prostatectomy (SRP) patients for recurrent prostate cancer.MethodsWithin a high‐volume center database, we identified patients who underwent SRP for recurrent prostate cancer (PCa) between 2004 and 2020. Upgrading, downgrading, concordance, and any discordance between posttreatment biopsy ISUP and ISUP at SRP were tested. Logistic regression models were used to predict ISUP upgrading and ISUP discordance. Models were adjusted for prostatic specific antigen before SRP, age at surgery, initial prostatic specific antigen (PSA), type of primary treatment, time from primary PCa diagnosis to SRP, number of positive cores at biopsy, and original Gleason score.ResultsOverall, 184 patients with available biopsy and pathologic ISUP grading were identified. Of those, 17.4% (n = 32), 40.8% (n = 75), 19.6% (n = 36), and 22.2% (n = 41) harbored biopsy ISUP 1, ISUP 2, ISUP 3, and ISUP 4–5 grading, respectively. Pathologic ISUP 1, ISUP 2, ISUP 3, and ISUP 4–5 grading was recorded in 6.0% (n = 11), 40.8% (n = 75), 32.1% (n = 59), and 21.2% (n = 39), respectively. Median PSA before SRP was 5.5 ng/ml (interquartile range [IQR]: 3.1–8.1 ng/ml), median age at SRP was 65.1 years (IQR:60.7–69.4 years) and median time from original PCa diagnosis to SRP was 47 months (IQR: 27.3–85.2 months). Concordance of biopsy and pathologic ISUP was identified in 45.1% (n = 83). Conversely, any ISUP discordance, upgrading and downgrading of at least one ISUP group was identified in 54.9% (n = 101), 35.3% (n = 65), and 19.6% (n = 36). In logistic models, none of the preoperative characteristics was associated with upgrading or ISUP discordance (all p > 0.1).ConclusionDiscordance between biopsy and pathologic ISUP grading is common at SRP. However, in 45% of SRP cases biopsy ISUP is capable to predict pathologic ISUP. Further studies are necessary to identify characteristics for ISUP upgrading at SRP.
Phase I clinical trial of HC‐1119 soft capsule in Chinese healthy adult male subjects: Pharmacokinetics and safety of single‐dose proportionality and effects of food
Authors: Ma Haiping , Xu Weidong , Ni Jin , Zhao Naping , Tang Shouyan , Li Song , Cai Tingting , Xiu Jianping , Kang Xin , Gao Shen , Zhang Li , Zhou Tie 
Published: November 2021

AbstractBackgroundPreclinical studies showed that HC‐1119, a deuterated version of enzalutamide, could competitively inhibit androgen binding to androgen receptor by blocking the transmission of androgen receptor signaling pathway as enzalutamide, inducing apoptosis of prostate cancer cells and reducing the proliferation of prostate cancer cells. Animal pharmacokinetic studies also show that deuterization of enzalutamide as HC‐1119 could retain the basic properties of mother drug, increases the stability of compounds to metabolic enzymes and the drug exposure in vivo, prolong the half‐life and reduce the production of metabolites, which may lead to a better efficacy and safety of HC‐1119 compared with enzalutamide.MethodsTo evaluate the pharmacokinetics and safety of HC‐1119 and the effects of food on pharmacokinetics in healthy adult Chinese men after single‐dose administration of HC‐1119. A total of 47 Chinese healthy adult male subjects received HC‐1119 soft capsule at a single oral dose of 40, 80, or 160 mg followed on fasting or 160 mg after high‐fat meal respectively. HC‐1119 prototype and its metabolites M1 and M2 in plasma were collected individually in a total 23 time points. Pharmacokinetics were determined by sensitive LC/MS/MS for dose‐proportionality study.ResultsIn subjects taking HC‐1119 soft capsules on fasting, Cmax of HC‐1119 prototype increased dose‐dependently. Either Cmax and AUC0‐∞ of M1 or Cmax of M2 showed statistically significant difference. Dose‐proportionality evaluation showed linear pharmacokinetic characteristics in Cmax of HC‐1119 prototype, Cmax and AUC0‐∞ of M2 in dose range of 40–160 mg. Cmax of HC‐1119 was significantly different between the two groups as 160 mg HC‐1119 on fasting or after a high‐fat diet respectively, while the other parameter were not. HC‐1119 and its metabolites M1 and M2 showed a linear dynamic trend.ConclusionsHC‐1119 is expected to have lower clinical dose than the similar drug enzalutamide. The absorption of HC‐1119 and the main pharmacokinetic parameters of HC‐1119 and its metabolites M1 and M2 were not affected by high‐fat diet. The clinical application of HC‐1119 soft capsule in the later stage can be recommended for both fasting and postprandial. The safety and tolerance were good in this population.
Feasibility and accuracy of orthopaedic surgical robot system for intraoperative navigation to locate bone tunnel in anterior cruciate ligament reconstruction
Authors: Ding Guocheng , Yang Gang , Zhang Jiahao , Huang Hongjie , Du Jianing , Ren Shuang , Wang Qining , Zhou Zhihao , Zhang Xin , Ao Yingfang 
Published: November 2021

AbstractBackgroundThe combination of navigational system and robotics has the potential to accurately identify and drill bone tunnels in anterior cruciate ligament (ACL) reconstruction. This study explores the feasibility and accuracy of bone tunnel positioning using the TiRobot, an orthopaedic surgical robot.MethodsThe experiment was divided into two groups. In group A, the bone tunnels were positioned using the TiRobot surgical robot (n = 8). In group B, handheld locators were used for positioning (n = 8).ResultsTiRobot can be used for positioning the ACL bone tunnel. The accuracy of positioning the femoral tunnel in group A and B was 1.00 ± 0.20 and 3.10 ± 0.59 mm, respectively (t = −9.49, P < 0.001). As for tibial tunnel, the accuracy was 1.02 ± 0.20 and 2.64 ± 0.14 mm, respectively (t = −18.54, P < 0.001).ConclusionsThe bone tunnel drilling precision using TiRobot for ACL reconstruction surgery was more accurate than traditional surgical techniques.
Genetic mapping reveals complex architecture and candidate genes involved in common bean response to Meloidogyne incognita infection
Authors: Giordani Willian , Gama Henrique Castro , Chiorato Alisson Fernando , Marques João Paulo Rodrigues , Huo Heqiang , Benchimol‐Reis Luciana Lasry , Camargo Luis Eduardo Aranha , Garcia Antonio Augusto Franco , Vieira Maria Lucia Carneiro 
Published: November 2021

AbstractRoot‐knot nematodes (RKNs), particularly Meloidogyne incognita, are among the most damaging and prevalent agricultural pathogens due to their ability to infect roots of almost all crops. The best strategy for their control is through the use of resistant cultivars. However, laborious phenotyping procedures make it difficult to assess nematode resistance in breeding programs. For common bean, this task is especially challenging because little has been done to discover resistance genes or markers to assist selection. We performed genome‐wide association studies and quantitative trait loci mapping to explore the genetic architecture and genomic regions underlying the resistance to M. incognita and to identify candidate resistance genes. Phenotypic data were collected by a high‐throughput assay, and the number of egg masses and the root‐galling index were evaluated. Complex genetic architecture and independent genomic regions were associated with each trait. Single nucleotide polymorphisms on chromosomes Pv06, Pv07, Pv08, and Pv11 were associated with the number of egg masses, and SNPs on Pv01, Pv02, Pv05, and Pv10 were associated with root‐galling. A total of 216 candidate genes were identified, including 14 resistance gene analogs and five differentially expressed in a previous RNA sequencing analysis. Histochemical analysis indicated that reactive oxygen species might play a role in the resistance response. Our findings open new perspectives to improve selection efficiency for RKN resistance, and the candidate genes are valuable targets for functional investigation and gene editing approaches.
Diagnosis and treatment of a low‐grade tracheal B‐cell lymphoma and associated complications in a mixed breed cat
Authors: Hart Julia , Dupré Gilles , Gumpenberger Michaela , Ludewig Eberhard , Cruz Benedetti Inga‐Catalina 
Published: November 2021

AbstractThis case report describes a low‐grade malignant B‐cell lymphoma (lymphocytic lymphoma) in a 14‐year‐old mixed breed cat, diagnosed by bronchoscopy and diagnostic imaging (radiography, ultrasound and computed tomography). The patient was treated with surgery, and postoperative complications included blindness and a severe mycoplasma infection of the thoracic cavity, which was treated using a vacuum‐assisted closure device. Long‐term therapy with prednisolone and chlorambucil and outcome with a survival time of 1385 days after discharge are also presented.
Prevalence of regurgitation and reingestion and occurrence of coprophagy in the North American AZA Gorilla (Gorilla gorilla gorilla) population
Authors: Tennant Kaylin S. , Dennis Patricia M. , Less Elena H. , Lukas Kristen E. 
Published: November 2021

AbstractThe aims of this study were to determine the current prevalence of regurgitation and reingestion (R/R) and gain an insight on the occurrence of coprophagy in the Association of Zoos & Aquariums (AZA) gorilla (Gorilla gorilla gorilla) population. To do this, an online survey was sent to all AZA accredited gorilla institutions in 2018. This survey collected information on the severity of R/R at the individual level and the occurrence of coprophagy at the zoo level. Previous research suggests more than half of zoo‐housed gorillas in the North American population engaged in R/R and coprophagy to some extent. The current study had a 100% response and completion rate; data were collected on all 296 noninfant gorillas in the population. Responses indicated that 60% of the AZA gorilla population engages in R/R to some degree and 24% of the population are observed exhibiting coprophagy on a weekly basis. With this preliminary information on coprophagy, and the realization that the Zoo community has been unsuccessful at eliminating R/R over the past 30 years, the next steps should be aimed at empirically assessing the potential drivers of these behaviors. Continuing efforts to further understand and eliminate R/R and coprophagy in zoo‐housed primates is important not only because these behaviors are unsightly to visitors, but more importantly, R/R and coprophagy may signal deficiencies in current practices surrounding animal care.
How is the distribution of psychological distress changing over time? Who is driving these changes? Analysis of the 1958 and 1970 British birth cohorts
Authors: Gondek Dawid , Lacey Rebecca E. , Blanchflower Dawid G. , Patalay Praveetha 
Published: November 2021

Abstract
Aims
The main objective of this study was to investigate distributional shifts underlying observed age and cohort differences in mean levels of psychological distress in the 1958 and 1970 British birth cohorts.

Methods
This study used data from the 1958 and 1970 British birth cohorts (n = 24,707). Psychological distress was measured by the Malaise Inventory at ages 23, 33, 42 and 50 in the 1958 cohort and 26, 34, 42 and 46–48 in the 1970 cohort.

Results
The shifts in the distribution across age appear to be mainly due to changing proportion of those with moderate symptoms, except for midlife (age 42–50) when we observed polarisation in distress— an increase in proportions of people with no symptoms and multiple symptoms. The elevated levels of distress in the 1970 cohort, compared with the 1958 cohort, appeared to be due to an increase in the proportion of individuals with both moderate and high symptoms. For instance, at age 33/34 42.3% endorsed at least two symptoms in the 1970 cohort vs 24.7% in 1958, resulting in a shift in the entire distribution of distress towards the more severe end of the spectrum.

Conclusions
Our study demonstrates the importance of studying not only mean levels of distress over time, but also the underlying shifts in its distribution. Due to the large dispersion of distress scores at any given measurement occasion, understanding the underlying distribution provides a more complete picture of population trends.
Nachweis der BRAF-V600E-Mutation beim metastasierten kolorektalen Karzinom
Authors: Jöhrens Korinna , Fischer Josephine , Möbs Markus , Junker Klaus , Kirfel Jutta , Perner Sven , Laßmann Silke , Werner Martin , Borgmann Vanessa , Bläker Hendrik , Hummel Michael 
Published: November 2021

ZusammenfassungRingversuche sind ein wichtiges Instrument zur Qualitätssicherung. Dies betrifft in zunehmendem Maße auch die molekulare Diagnostik in der Pathologie, von deren Ergebnissen Therapieentscheidungen in der Präzisionsonkologie direkt abhängen. Beim metastasierten kolorektalen Karzinom (mKRK) stand bisher der Nachweis von KRAS-und NRAS-Mutationen im Vordergrund, deren Abwesenheit eine Therapie mit EGFR-blockierenden Antikörpern ermöglicht. Nun ist BRAF als weiterer prädiktiver Marker hinzugekommen, da mKRK Patienten mit einer BRAF-V600E-Mutation nach systemischer Vortherapie von einer Behandlung mit Encorafenib (einem BRAF-Inhibitor) in Kombination mit Cetuximab (Anti-EGFR-Antikörper) profitieren. Aufgrund der 2020 erfolgten Zulassung für diese Behandlung ist es wichtig, dass der diagnostische Nachweis einer BRAF-V600E-Mutation zuverlässig in den Pathologien durchgeführt werden kann. Daher wurde dieser Ringversuch durchgeführt, bei dem der Nachweis der BRAF-V600E-Mutation entweder mittels Immunhistochemie oder molekularer Verfahren erfolgen konnte. Die Ergebnisse des Ringversuchs belegen eindeutig, dass derzeit die molekulare BRAF-V600E-Bestimmung dem immunhistologischen Nachweis überlegen ist.