bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid microbial methanogenesis during CO2 storage in hydrocarbon reservoirs
Authors: Tyne R. L. , Barry P. H. , Lawson M. , Byrne D. J. , Warr O. , Xie H. , Hillegonds D. J. , Formolo M. , Summers Z. M. , Skinner B. , Eiler J. M. , Ballentine C. J. 
Published: December 2021

AbstractCarbon capture and storage (CCS) is a key technology to mitigate the environmental impact of carbon dioxide (CO2) emissions. An understanding of the potential trapping and storage mechanisms is required to provide confidence in safe and secure CO2 geological sequestration1,2. Depleted hydrocarbon reservoirs have substantial CO2 storage potential1,3, and numerous hydrocarbon reservoirs have undergone CO2 injection as a means of enhanced oil recovery (CO2-EOR), providing an opportunity to evaluate the (bio)geochemical behaviour of injected carbon. Here we present noble gas, stable isotope, clumped isotope and gene-sequencing analyses from a CO2-EOR project in the Olla Field (Louisiana, USA). We show that microbial methanogenesis converted as much as 13–19% of the injected CO2 to methane (CH4) and up to an additional 74% of CO2 was dissolved in the groundwater. We calculate an in situ microbial methanogenesis rate from within a natural system of 73–109 millimoles of CH4 per cubic metre (standard temperature and pressure) per year for the Olla Field. Similar geochemical trends in both injected and natural CO2 fields suggest that microbial methanogenesis may be an important subsurface sink of CO2 globally. For CO2 sequestration sites within the environmental window for microbial methanogenesis, conversion to CH4 should be considered in site selection.
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection
Authors: Dowell Alexander C. , Butler Megan S. , Jinks Elizabeth , Tut Gokhan , Lancaster Tara , Sylla Panagiota , Begum Jusnara , Bruton Rachel , Pearce Hayden , Verma Kriti , Logan Nicola , Tyson Grace , Spalkova Eliska , Margielewska-Davies Sandra , Taylor Graham S. , Syrimi Eleni , Baawuah Frances , Beckmann Joanne , Okike Ifeanyichukwu O. , Ahmad Shazaad , Garstang Joanna , Brent Andrew J. , Brent Bernadette , Ireland Georgina , Aiano Felicity , Amin-Chowdhury Zahin , Jones Samuel , Borrow Ray , Linley Ezra , Wright John , Azad Rafaq , Waiblinger Dagmar , Davis Chris , Thomson Emma C. , Palmarini Massimo , Willett Brian J. , Barclay Wendy S. , Poh John , Amirthalingam Gayatri , Brown Kevin E. , Ramsay Mary E. , Zuo Jianmin , Moss Paul , Ladhani Shamez 
Published: December 2021

AbstractSARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Neutralization of viral variants was comparable between children and adults. Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses. Importantly, children retained antibody and cellular responses 6 months after infection, whereas relative waning occurred in adults. Spike-specific responses were also broadly stable beyond 12 months. Therefore, children generate robust, cross-reactive and sustained immune responses to SARS-CoV-2 with focused specificity for the spike protein. These findings provide insight into the relative clinical protection that occurs in most children and might help to guide the design of pediatric vaccination regimens.
Association between magnesium concentrations and prediabetes: a systematic review and meta-analysis
Authors: Ebrahimi Mousavi Sara , Ghoreishy Seyed Mojtaba , Hemmati Amirhossein , Mohammadi Hamed 
Published: December 2021

AbstractStudies on the association between serum magnesium level and prediabetes yielded inconsistent results. Therefore, the present meta-analysis was designed to examine the association between serum magnesium levels and prediabetes. Online databases including PubMed, Embase, Scopus and Google Scholar were searched up to October, 2020. A total of 10 studies that reported mean and standard deviation (SD) of magnesium levels in prediabetes and healthy control group were identified. Random effects models were used to pool weighted mean differences (WMDs) of serum magnesium levels. Pooled-analysis showed that subjects with prediabetes had significantly lower serum magnesium levels compared with healthy controls (WMD =  − 0.07 mmol/L; 95% CI − 0.09, − 0.05 mmol/L, P < 0.001). A significant heterogeneity observed across included studies (I2 = 95.6%, P < 0.001). However, different subgroup analysis did not detect the potential source of observed heterogeneity. Withdrawal of each individual study had no effect on the overall results. The present meta-analysis showed that circulating magnesium levels in people with prediabetes were significantly lower than healthy controls, confirming that magnesium deficiency may play a role in development and progression of prediabetes. Further studies with larger sample size and robust design are warranted to confirm present results.
Facilitators and Barriers to Implementing the International Dysphagia Diet Standardisation Initiative in Care Facilities in Upstate New York
Authors: Harvey Caileen , Flemming Rachel , Davis Julia , Reynolds Victoria 
Published: December 2021

Introduction:
Dysphagia is a swallowing disorder that can result in aspiration, asphyxiation, or other complications. One method of facilitating safer swallowing is modification of the diet and fluids of individuals living with dysphagia. The International Dysphagia Diet Standardisation Initiative (IDDSI) is a globally standardized framework for texture modification. Its implementation has been recommended in the United States, but adoption is not yet universal. This study investigated implementation issues by surveying health care professionals in health care facilities in rural, Upstate New York.

Method:
A questionnaire created through the SurveyMonkey platform was distributed to health care facilities within a predetermined geographical area in Upstate New York. The survey consisted of 22 questions and utilized a mixed-methods design.

Results:
Forty-six participants from 10 individual professions and nine types of facilities completed the study. Twenty texture modification labels and 10 fluid modification labels were described. Analysis of qualitative data yielded three main barriers to implementation: funding, education, and communication. Within each barrier, awareness and resources were recurrent themes.

Discussion:
The variety of modification labels in comparison with the sample size demonstrates a lack of standardization of texture modification processes across facilities. While nearly half the respondents had not heard of IDDSI prior to the survey, 89% agreed that a standardized dysphagia diet would improve patient health and safety. This demonstrated a willingness to adopt IDDSI and indicated that staff attitudes may not be a barrier to its implementation. Participants felt that training was needed for successful implementation and expressed concern about the lack of availability of financial resources.

Supplemental Material:

https://doi.org/10.23641/asha.17270861
Dynamic reactive power optimization of distribution network with distributed generation based on fuzzy time clustering
Authors: Ji Yuqi , Chen Xuehan , Wang Tao , He Ping , Jin Nan , Li Congshan , Tao Yukun 
Published: December 2021

AbstractIn order to solve the coordinated optimization problem of distributed generation (DG), on‐load tap changer (OLTC) and capacitor banks, a dynamic reactive power optimization (DRPO) method based on fuzzy time clustering is proposed. In the method, fuzzy time clustering algorithm is used to cluster the static optimal switching sequence of OLTC and capacitor banks. The time decoupling of control variables is realized and it meets the constraints of the maximum switching times. Next, the influencing factors of DG reactive power limit are analysed. Considering the control ability of OLTC, capacitor banks and DG in voltage and reactive power optimization, a coordinated optimization method is proposed. Since the adjustment of OLTC tap position directly affects the voltage and reactive power distribution of the whole line, the switching time and tap position of OLTC are determined based on the static optimization results of each time and fuzzy time clustering algorithm. Then, the switching time of capacitor banks is determined by fuzzy time clustering algorithm. At last, the switching capacity of capacitor banks and DG reactive power are jointly optimized to get the final control scheme. The proposed method demonstrated good performance in the modified IEEE33 node system and two actual power grid examples.
Single‐layer tri‐state switching as an economical method to address linear light‐emitting diode arrays
Authors: Klein Eric , Ruther Patrick , Paul Oliver 
Published: December 2021

AbstractThis paper reports on new schemes based on the concept of tri‐state switching for routing linear arrays of light‐emitting diodes (LEDs) on slim substrates. The schemes use a minimal number of wires in single‐metal planar technologies, where wires are not allowed to cross. They have in common that the number of LEDs, NL, addressable by NW wires is given by NL = 4NW − 6. The designs are built on a family of hierarchically interconnected structures with (2n+1 − 2) LEDs and (2n−1 + 1) wires, for positive integers n. A process termed linear expansion straightforwardly extends them to arbitrary values of NW and adds 4 LEDs with each additional wire. Expressions for series resistances and the average wire length normalized to the array length are derived. In hierarchical designs, the average normalized wire length asymptotically approaches 7/12 for large n. A matrix formulation graphically elucidates the new interconnection schemes.
Fragebogen zur Erfassung der medizinisch-beruflichen Orientierung der
Rehabilitation aus der Perspektive der Rehabilitanden (MBOR-R):
Querschnittsstudie zum Vergleich der Kurz- und Langversion
Authors: Bürger Wolfgang , Nübling Rüdiger , Streibelt Marco 
Published: December 2021

Zusammenfassung
Hintergrund Die Nutzerwahrnehmung des erwerbsbezogenen
Behandlungsangebotes ist von großer Bedeutung für die
Weiterentwicklung und den Erfolg der medizinisch-beruflich orientierten
Rehabilitation (MBOR). Die Deutsche Rentenversicherung (DRV) Bund hat deshalb
die Entwicklung des Fragebogeninstrumentes MBOR-R gefördert, mit dessen
Hilfe Struktur-, Prozess- und Ergebnisqualität speziell des
erwerbsbezogenen Angebotes aus Rehabilitandensicht erfasst werden
können. In diesem Beitrag wird eine Kurzversion vorgestellt und mit der
Langversion verglichen.
Methodik Basierend auf einer repräsentativen, nach
Indikationsbereichen geschichteten Stichprobe wurden berufstätige
Versicherte bis 65 Jahren ein halbes Jahr nach ihrer Rehabilitation
zufallsgesteuert mit einer Langversion (N=28 276) oder einer
Kurzversion (N=6611) von MBOR-R befragt. Ergänzend wurden
Routinedaten des Rehabilitationsträgers (RSD) mit einbezogen. Je 27
Items der Langversion und 8 Items der Kurzversion wurden zu einem Gesamtwert
aufaddiert und im Hinblick auf teststatistische Gütekriterien und
Stichprobensensitivität verglichen.
Ergebnisse Die Teilnahmequoten lagen bei der Kurzversion mit 31%
(N=2115) geringfügig über der der Langversion mit
28% (N=8019). Die Bearbeitungsqualität in beiden
Versionen ist vergleichbar. Kurz- und Langversion korrelieren zu r=0,96
(p<0,01) miteinander. Beide Versionen weisen ähnliche Validitätskennwerte auf und
trennen gut zwischen MBOR und Standardrehabilitation. Sie sind beide robust gegenüber demografischen, krankheitsbezogenen sowie
sozialmedizinischen Risikofaktoren. Rehabilitanden mit Sucht und
psychosomatischen sowie neurologischen Erkrankungen bewerten ihre Rehabilitation
als deutlich stärker erwerbsorientiert im Vergleich zu anderen
Indikationen, insbesondere der Pneumologie.
Schlussfolgerung Die Kurzversion eignet sich aufgrund des geringen
Erhebungsaufwandes und der einfachen Auswertung und Interpretation v. a.
für routinemäßige Erhebungen der
MBOR-Versorgungsqualität. Die Langversion erlaubt eine differenzierte
Erfassung des MBOR-Angebotes von Rehabilitationseinrichtungen im Sinne von
Stärken-/Schwächen-Analysen.
Geographical Distribution of Access to Healthcare in Patients Diagnosed with Hypospadias
Authors: Fernandez Nicolas , Santander Jessica , Pérez-Sosa Marcela , Agudelo Alejandro , Sánchez Daniel , Vélez Nevianni , Zarante Ignacio , Gutierrez Andres 
Published: December 2021

Abstract
Objective Hypospadias is a congenital disease of unknown etiology involving multiple epigenetic, genetic, and endocrinological factors. It is a highly incapacitating condition. Its surgical management is one of the most frequent surgical procedures done by pediatric urologists. Furthermore, the geographical distribution and healthcare access is limited in Colombia. The Colombian Ministry of Health has consolidated a nationwide registry called Integrated Social Protection Information System (SISPRO, in the Spanish acronym) to collect comprehensive information on the use and frequency of resources associated with health care in Colombia. The aim of the present study was to analyze the number of cases reported between 2014 and 2018 and the geographical distribution of access to healthcare of patients with hypospadias in Colombia.
Methods An observational, retrospective study of hypospadias in Colombia, 2014–2018, was performed using data extracted from the Individual Health Records System (RIPS) in SISPRO. Satscan, version 9.6 was used to perform a distribution analysis of the georeferenced population using a Poisson model. To visualize the results, the software projected the result onto a Google Earth map.
Results Between January 2014 and December 2018, a total of 8,990 cases of hypospadias were evaluated in Colombia. The geographical distribution in the national territory has areas with high evaluation rates. On average, the departments in which the majority of cases were evaluated during the study period were Bogotá, D.C., Antioquia, and Valle del Cauca (2,196, 1,818 and 1,151 cases, respectively). The statistical analysis of the space exploration (Fig. 1) identified the area with the highest concentration of cases (red) and the areas in which the lowest number of patients was evaluated (blue). The geographical distribution showed increasing trends in areas near the center of the country, especially in the cities of Bogotá, Cali, Ibagué, and Pereira.
Conclusion There is a greater concentration of cases evaluated in the center of the country, where the cities with better access to subspecialized medical care are located. This highlights inequalities in health services and the opportunity for surgical care among regions of the country. If we consider that the prevalence rates of hypospadias remain stable, ∼ 87% of the patients with hypospadias will not be evaluated by a subspecialist.
Orthobiologics: Diagnosis and Treatment of Common Tendinopathies
Authors: Van Schaik Katherine D. , Lee Kenneth S. 
Published: December 2021

AbstractOrthobiologics, including platelet-rich plasma, prolotherapy, and mesenchymal stem cells, are seeing increasing use in the treatment of osteoarthritis (OA), muscle injury, and tendinopathy. This article reviews the biology and applications of orthobiologics in tendons, muscles, and joints, and focuses on platelet-rich plasma (PRP). Clinical evidence-based literature related to the use of PRP in the treatment of rotator cuff injury, lateral epicondylosis, Achilles tendinopathy, plantar fasciitis, knee OA, and acute muscle injury are discussed.
Tratamiento de la fractura conminuta de patela: ¿existen diferencias entre realizar o no una eversión?
Authors: Carredano G Xabier , Valderrama R Juanjosé , Valderrama S Ignacio , Hube L Maximiliano , Bernal B Nazira , Mellado M Carolina , Espinoza L Gonzalo 
Published: December 2021

Resumen
Objetivo Comparar los resultados clínicos, funcionales e imagenológicos de dos técnicas quirúrgicas para el manejo de fracturas conminutas de patela: con y sin eversión patelar.
Métodos En una serie de casos retrospectivos de fracturas conminutas de patela tratadas en el mismo centro entre 2014 y 2017, con un seguimiento ≥ 3 meses, se hizo una comparación entre el grupo con eversión y el grupo sin eversión. Los criterios de exclusión fueron patelectomía parcial o total, reinserción tendínea, o rehabilitación incompleta. Las variables analizadas fueron edad, sexo, tabaquismo, diabetes mellitus, energía del accidente, tipo de fractura, variables quirúrgicas (banda de tensión, tornillos, alambres, nudos, cerclaje circular), rango de movimiento (RDM) articular postoperatorio, presencia de osteosíntesis sintomática, puntaje de escalas funcionales (de Tegner-Lysholm y de Kujala) al alta definitiva, complicaciones (rigidez articular, infección, trombosis venosa profunda), y variables imagenológicos con tomografías computarizadas pre- y postoperatorias (brecha, desnivel articular > 2 mm, elementos de fijación intraarticular).
Resultados En total, 20 de 22 pacientes, 13 con eversión y 7 sin eversión, cumplieron con los criterios de selección. El seguimiento fue de 3 a 12 meses, y no hubo diferencias estadísticamente significativas respecto a las variables demográficas entre ambos grupos, lo cual los hace comparables. Destacaron el tiempo desde el ingreso al alta, con 7 meses para los pacientes con eversión y 5 meses para los sin eversión (p = 0.032), la proporción de pacientes con desnivel articular > 2 mm, con 7.7% para los con eversión y 14.3% para los sin eversión (p = 0.016), y una tendencia a resultados superiores en escalas funcionales para el grupo con eversión.
Conclusión El tratamiento de fracturas conminutas de patela con eversión parece ser una alternativa viable dados sus resultados imagenológicos y funcionales superiores a los de la técnica habitual.
Disfunción sexual femenina: una mirada a los últimos 44 años. Análisis bibliométrico
Authors: Ceballos Domínguez Maria del Pilar , Vásquez Franco Andrea , Arroyo Malaver Lisset Fernanda , Castillo Carvajal Luisana , Montes Johanna María , Perdomo Pamela , Vega Johanna , Solano Mendoza Catalina 
Published: December 2021

Resumen
Objetivo La disfunción sexual femenina (DSF) es un trastorno prevalente que afecta la calidad de vida de las mujeres y combina factores biológicos, psicológicos e interpersonales. Su estudio ha sido de poco interés, en campos como la investigación y el tratamiento, debido a la dificultad en la medición de las respuestas sexuales en las mujeres y otros factores, como el tabú acerca de la sexualidad femenina. Este estudio caracteriza las tendencias de publicaciones científicas acerca del tema, para que los urólogos puedan comprender la necesidad de realizar la búsqueda de este trastorno en la práctica diaria.
Métodos Se realizó una búsqueda de la literatura en las bases de datos PubMed, FABUMED y Scopus, utilizando la estrategia «((«female sexual dysfunction» [Title/Abstract])». Se realizó un análisis bibliométrico descriptivo, de corte retrospectivo, de la literatura médica obtenida en MEDLINE. A través de las herramientas estadísticas FABUMED, PubReminer y Scopus, se recopilaron los datos y se obtuvo los resultados de las variables que posteriormente fueron analizadas de forma estadística y descriptiva. Con base en esta información, elaboramos tablas y gráficas en Microsoft Office Excel 2017. Adicionalmente, realizamos un análisis de mapeo bibliométrico utilizando el programa VOSviewer. Para la obtención del factor de impacto (FI), utilizamos el Journal Citation Reports 2017/2018.
Resultados Desde 1975 hasta 2019, se publicaron 1.292 estudios, y la tasa anual de publicación permaneció estable entre 1975 y 2000. Pero, a partir del año 2000, se evidenció un aumento en el número de publicaciones, con un crecimiento del 92,1%. De las veinte revistas con más publicaciones, sólo cuatro son de urología. Los países con más publicaciones fueron: Estados Unidos (31,4%), Reino Unido (12,9%), Italia (8,9%), Turquía (5,9%), y Australia (4%). Estos datos son muy diferentes a los de los países de América Latina, en los que se encontraron muy pocas publicaciones, como Colombia, con tan sólo tres estudios.
Conclusiones Este análisis bibliométrico mostró las diferentes tendencias y tasas de publicación de estudios sobre DSF, y evidenció una baja tasa de producción con relación a otras temáticas, sobre todo en las revistas urológicas, con predominio de mujeres como autores, aunque en los últimos años se ha identificado un crecimiento importante y sostenido. Se hace evidente la necesidad de desarrollar estrategias para mejorar la formación tanto en los niveles de posgrado como de pregrado y, así, generar más adhesión a este tema en una especialidad quirúrgica como la nuestra.
Multiplexed two-photon excitation spectroscopy of single gold nanorods
Authors: Vlieg Redmar C. , van Noort John 
Published: December 2021

Plasmonic metallic nanoparticles are commonly used in (bio-)sensing applications because their localized surface plasmon resonance is highly sensitive to changes in the environment. Although optical detection of scattered light from single particles provides a straightforward means of detection, the two-photon luminescence (TPL) of single gold nanorods (GNRs) has the potential to increase the sensitivity due to the large anti-Stokes shift and the non-linear excitation mechanism. However, two-photon microscopy and spectroscopy are restricted in bandwidth and have been limited by the thermal stability of GNRs. Here, we used a scanning multi-focal microscope to simultaneously measure the two-photon excitation spectra of hundreds of individual GNRs with sub-nanometer accuracy. By keeping the excitation power under the melting threshold, we show that GNRs were stable in intensity and spectrum for more than 30 min, demonstrating the absence of thermal reshaping. Spectra featured a signal-to-noise ratio of &gt;10 and a plasmon peak width of typically 30 nm. Changes in the refractive index of the medium of less than 0.04, corresponding to a change in surface plasmon resonance of 8 nm, could be readily measured and over longer periods. We used this enhanced spectral sensitivity to measure the presence of neutravidin, exploring the potential of TPL spectroscopy of single GNRs for enhanced plasmonic sensing.