bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between building attributes and room rates for private home rentals converted from quaint old houses in Osaka City through a hedonic approach
Authors: Kondo Rei , Matsushita Daisuke 
Published: March 2021

AbstractTwo groups of hedonic price models were constructed, one for quaint old private home rentals and the other for non‐quaint old private home rentals. In the case of quaint old private home rentals, a higher presence of traditional design corresponded to higher room rates. In the case of non‐quaint old private home rentals, closer distances to a train station and higher roadside land prices corresponded to higher room rates. A potential market was found for private home rentals of homes converted from old houses that had lost their market value as residences.
Multicenter randomized phase II study comparing docetaxel plus curcumin versus docetaxel plus placebo in first‐line treatment of metastatic castration‐resistant prostate cancer
Authors: Passildas‐Jahanmohan Judith , Eymard Jean‐Christophe , Pouget Mélanie , Kwiatkowski Fabrice , Van Praagh Isabelle , Savareux Laurent , Atger Marc , Durando Xavier , Abrial Catherine , Richard Damien , Ginzac Couvé Angeline , Thivat Emilie , Monange Brigitte , Chollet Philippe , Mahammedi Hakim 
Published: March 2021

AbstractBackgroundMetastatic castration‐resistant prostate cancer (mCRPC) patients have a poor prognosis, and curcumin is known to have antineoplastic properties. On the basis of previous phase I and phase II studies, we investigated whether the association of curcumin with docetaxel could improve prognosis among mCRPC patients.MethodsA total of 50 mCRPC patients (included from June 2014 to July 2016) treated with docetaxel in association with oral curcumin (6 g/d for 7 days every 3 weeks) versus placebo were included in this double‐blind, randomized, phase II study. The primary endpoint was to evaluate the time to progression. Among the secondary endpoints, compliance, overall survival, prostate‐specific antigen (PSA) response, safety, curcumin absorption, and quality of life were investigated. An interim analysis was planned in the modified intention‐to‐treat population with data at 6 months (22 patients per arm).ResultsDespite good compliance and a verified absorption of curcumin, no difference was shown for our primary endpoint: progression‐free survival (PFS) between the placebo and curcumin groups was, respectively, 5.3 months versus 3.7 months, p = 0.75. Similarly, no difference was observed for the secondary objectives: PSA response rate (p = 0.88), overall survival (p = 0.50), and quality of life (p = 0.49 and p = 0.47).ConclusionEven though our previous studies and data in the literature seemed to support an association between curcumin and cancer therapies in order to improve patient outcome and prognosis, the results from this interim analysis clearly showed that adding curcumin to mCRPC patients’ treatment strategies was not efficacious. The study was discontinued on the grounds of futility.
Cervical Lymph Node Features Predictive of Suboptimal Adequacy During Ultrasound‐Guided Fine‐Needle Aspiration in Thyroid Cancer Patients
Authors: Chen Joshua Vic , Morgan Tara A. , Liu Chienying , Khanafshar Elham , Choi Hailey H. 
Published: March 2021

PurposeTo determine the rate of cytologic and diagnostic adequacy and identify features associated with suboptimal tissue sampling in ultrasound‐guided fine‐needle aspiration (US‐FNA) of suspected nodal disease in thyroid cancer patients.MethodsA single‐institution pathology database was queried for lymph node FNA reports in thyroid cancer patients from 2014 to 2019. Charts were reviewed for demographics, body mass index (BMI), prior thyroidectomy, cancer type, and subsequent surgery. Ultrasound images were retrospectively reviewed for location, size, depth from skin, cystic components, macrocalcification, echogenic foci, and internal vascularity score. Pathology reports were categorized as cellular and diagnostic, hypocellular/acellular but diagnostic with abnormal cells or thyroglobulin levels, or hypocellular and nondiagnostic. Correlation and multivariate regression analyses were performed.ResultsInitial query yielded 552 lesions in 343 subjects. Following exclusion, 377 lesions in 255 subjects were included. Mean patient age was 48.5 years (14–90), BMI 28.5, and 66.7% female and 33.3% male. The majority (95.3%) had papillary thyroid carcinoma (PTC); and 65.5% had prior thyroidectomy. 17.7% of lesions were hypocellular/acellular (suboptimal), and 5.6% nondiagnostic. Patient factors had no association (P >.05). Right‐sidedness and hypovascularity were associated with hypocellularity (P <.05). Higher long/short‐axis ratio and cystic foci were weakly associated. On multivariate analysis, right‐sidedness (odds ratio [OR] 1.99; confidence interval [CI] 1.10–3.57) and lower vascularity score (OR 0.54; CI 0.39–0.73) were predictive of suboptimal sampling.ConclusionUS‐FNA has high diagnostic yield and cellular sample rate. Lesion size had no effect. Right‐sidedness and lower vascularity scores were predictive of suboptimal tissue. Identifying these features and expected sample adequacy rates can inform management decisions for thyroid cancer patients with cervical lymphadenopathy.
Drammatic breaks: Break recovery experiences as mediators between job demands and affect in the afternoon and evening
Authors: Virtanen Anniina , Van Laethem Michelle , de Bloom Jessica , Kinnunen Ulla 
Published: March 2021

AbstractThe present study focused on within‐workday recovery, which has received less scholarly attention than has recovery outside work. We examined six break recovery experiences (detachment, relaxation, autonomy, mastery, meaning and affiliation) as possible mediators between daily emotional job demands, positive and negative affect both in the afternoon and in the evening. We conducted a one‐work week diary study (N = 107) among Finnish schoolteachers with three daily measurements per workday. Most participants (88%) were women, and the average age was 50 years. The data were analysed with multilevel path modelling. Regarding daily afternoon affect, both low break detachment and low break meaning mediated the relationship between high daily emotional demands and low afternoon positive affect and high afternoon negative affect. Regarding daily evening affect, only low break meaning mediated the relationship between high daily emotional demands and low evening positive affect. In addition, afternoon positive and negative affect did mediate the relationships between break detachment and meaning and positive and negative evening affect. Our findings offer new insights into the interplay of daily job demands, break recovery experiences and affective well‐being. Despite detachment, meaning, which has received limited research attention as a recovery experience, seems to play an important role in within‐workday recovery. Our study also suggests that successful break recovery can benefit employees' affective well‐being in the evening.
Teamarbeit und Stress bei Routineeingriffen: eine Beobachtungsstudie multiprofessioneller OP-Teams
Authors: Passauer-Baierl Stefanie , Stumpf Ulla , Weigl Matthias 
Published: March 2021

Zusammenfassung
Hintergrund
Effektive interprofessionelle Teamarbeit im Operationssaal (OP) und intraoperativer Stress sind von großer Bedeutung für Patientensicherheit und Versorgungsqualität. Dennoch gibt es nur wenige systematische Studien zum Zusammenhang von Teamarbeit im OP und Arbeitsstress.

Ziele der Arbeit
Untersuchung des Zusammenhangs von Teamarbeit und empfundenem Stress bei Routineeingriffen – für das OP-Team als Gesamtheit sowie für die einzelnen Professionen Chirurgie, Anästhesie und Pflege.

Material und Methoden
Durchgeführt wurde eine Mehrmethodenstudie bestehend aus Expertenbeobachtungen mittels eines standardisierten Beobachtungsinstruments (OTAS-D) und systematischer Selbstberichte des gesamten OP-Teams. Erfasst wurden 64 elektive Routineeingriffe unterschiedlicher chirurgischer Fachbereiche. Die statistischen Zusammenhangsanalysen unter Kontrolle prozeduraler Einflussfaktoren wurden mit „Mixed-effects“-Regressionsmodellen berechnet.

Ergebnisse
Die Güte der intraoperativen Teamarbeit lag auf mittlerem Niveau. Der situative Stress während des Eingriffs wurde durch die Befragten eher auf niedrigerem Niveau berichtet, mit signifikanten Unterschieden zwischen den Professionen Chirurgie, Pflege und Anästhesie. Mitglieder des chirurgischen Teams berichteten im Durchschnitt die höchsten Stressniveaus. Ein genereller Zusammenhang zwischen Teamarbeit und Stresserleben konnte nicht beobachtet werden, allerdings für die einzelnen Professionen: Für das chirurgische Team ergaben sich signifikante, positive Zusammenhänge, sowie für die Teamarbeitsdimensionen Zusammenarbeit und Führung. Signifikante negative Zusammenhänge ergaben sich für das Pflegeteam hinsichtlich der Qualität der interdisziplinären Teamarbeit insgesamt sowie für die Teamarbeitsdimension Team-Monitoring.

Diskussion
Die Effekte interprofessioneller Zusammenarbeit im OP auf subjektives Stressempfinden bei Routineeingriffen hängen von Professionszugehörigkeit, Aufgabe und Tätigkeit ab. Weitere Forschungsarbeit ist notwendig, inwiefern gute Teamarbeit bei Routineeingriffen innerhalb und über die Professionen hinweg intraoperativen Stress beeinflusst.
Is It Freedom? The Coming About of the EU Directive on Whistleblower Protection
Authors: Vandekerckhove Wim 
Published: March 2021

AbstractIn November 2019 the EU Whistleblower Directive came into force. Whistleblowing has been described as a human right and a freedom fundamental to democracy. But it is not always straightforward to understand concrete cases of reporting wrongdoing in terms of abstract political philosophy. This paper uses a discussion between Berlin and Skinner about what negative freedom is, as a theoretical framework to understand the struggles of a campaigning platform of trade unions and civil society organizations, in the coming about of the EU Whistleblower Directive. The paper is empirically based on a document analysis of two Resolutions in the European Parliament, the European Commission’s proposal text, the approved text in the European Parliament, and messages on the listserv of the campaigning platform between February 2017 and April 2019. The paper provides insights on how whistleblowing freedom relates to public interest and autonomy.
Software product-line evaluation in the large
Authors: Lindohf Robert , Krüger Jacob , Herzog Erik , Berger Thorsten 
Published: March 2021

AbstractSoftware product-line engineering is arguably one of the most successful methods for establishing large portfolios of software variants in an application domain. However, despite the benefits, establishing a product line requires substantial upfront investments into a software platform with a proper product-line architecture, into new software-engineering processes (domain engineering and application engineering), into business strategies with commercially successful product-line visions and financial planning, as well as into re-organization of development teams. Moreover, establishing a full-fledged product line is not always possible or desired, and thus organizations often adopt product-line engineering only to an extent that deemed necessary or was possible. However, understanding the current state of adoption, namely, the maturity or performance of product-line engineering in an organization, is challenging, while being crucial to steer investments. To this end, several measurement methods have been proposed in the literature, with the most prominent one being the Family Evaluation Framework (FEF), introduced almost two decades ago. Unfortunately, applying it is not straightforward, and the benefits of using it have not been assessed so far. We present an experience report of applying the FEF to nine medium- to large-scale product lines in the avionics domain. We discuss how we tailored and executed the FEF, together with the relevant adaptations and extensions we needed to perform. Specifically, we elicited the data for the FEF assessment with 27 interviews over a period of 11 months. We discuss experiences and assess the benefits of using the FEF, aiming at helping other organizations assessing their practices for engineering their portfolios of software variants.
Genetic variation of seed phosphorus concentration in winter oilseed rape and development of a NIRS calibration
Authors: Eifler Jakob , Wick Jürgen Enno , Steingrobe Bernd , Möllers Christian 
Published: March 2021

AbstractPhytic acid is the major organic phosphorus storage compound in rapeseed. Following oil extraction, the defatted meal is used in feed mixtures for livestock. However, monogastric pigs and chickens can only poorly metabolize phytate. Hence, their excrements are rich in phosphorus (P), which when applied as manure may lead to eutrophication of surface waters. The aim of the present study was to analyze the genetic variation for total and organic P concentration (i.e. mainly phytate) in rapeseed and to compare the results with soybean. Two sets of rapeseed material were tested in field experiments in different environments with varying soil P levels and harvested seeds were used for seed quality analysis. Results revealed significant genotypic differences in total seed P concentration, which ranged from 0.47 to 0.94%. Depending on the experiment, the heritability for total P concentration ranged from 52 to 93%. The organic P portion of total P concentration was above 90% for current rapeseed hybrids. In both sets, there was a significant positive correlation between seed protein and P concentration. A NIRS calibration for total P concentration in intact seeds showed in cross validation a standard error of 0.05% and a coefficient of determination of R2 = 0.83. Total P concentration of soybean seeds and meal was between 0.55 and 0.65%, and around 1.1% for rapeseed meal. Rapeseed meal had a twofold higher ratio of total P to nitrogen concentration as compared to soybean which could be considered adverse when the meal is used for feeding livestock.
ExoSim: the Exoplanet Observation Simulator
Authors: Sarkar Subhajit , Pascale Enzo , Papageorgiou Andreas , Johnson Luke J. , Waldmann Ingo 
Published: March 2021

AbstractA new generation of exoplanet research beckons and with it the need for simulation tools that accurately predict signal and noise in transit spectroscopy observations. We developed ExoSim: an end-to-end simulator that models noise and systematics in a dynamical simulation. ExoSim improves on previous simulators in the complexity of its simulation, versatility of use and its ability to be generically applied to different instruments. It performs a dynamical simulation that can capture temporal effects such as correlated noise and systematics on the light curve. It has also been extensively validated, including against real results from the Hubble WFC3 instrument. We find ExoSim is accurate to within 5% in most comparisons. ExoSim can interact with other models which simulate specific time-dependent processes. A dedicated star spot simulator allows ExoSim to produce simulated observations that include spot and facula contamination. ExoSim has been used extensively in the Phase A and B design studies of the ARIEL mission, and has many potential applications in the field of transit spectroscopy.
Just look at to open it up:
Authors: Smiatacz Maciej , Wiszniewski Bogdan 
Published: March 2021

AbstractElectronic documents constitute specific units of information, and protecting them against unauthorized access is a challenging task. This is because a password protected document may be stolen from its host computer or intercepted while on transfer and exposed to unlimited offline attacks. The key issue is, therefore, making document passwords hard to crack. We propose to augment a common text password authentication interface to encrypted documents with a biometric facial identity verification providing highly personalized security mechanism based on pseudo-identities. In consequence the encrypted document can be unlocked with the legitimate user’s face, while for everyone else stays encrypted with a hard to crack text password. This paper makes two contributions: (1) The proposed scheme enables password autofill without referring to any external service, which significantly limits the possibilities of an attack by adversaries when opening, reading and editing the protected document, (2) By the adoption of biometric verification techniques enabling fine-tuning of false acceptance and false rejection rates, it provides for responsible adaptation to users.
Energetic and geometric characteristics of the substituents. Part 1. The case of NO2 and NH2 groups in their mono-substituted derivatives of simple benzenoid hydrocarbons
Authors: Wieczorkiewicz Paweł A. , Szatylowicz Halina , Krygowski Tadeusz M. 
Published: March 2021

AbstractSimple polycyclic aromatic hydrocarbons, substituted by strongly electron-donating (NH2) and withdrawing (NO2) groups, are studied employing density functional theory (DFT) calculations. A new approach to a description of the substituent effect, the energy of substituent, E(X), is proposed and evaluated. It is defined as E(X) = E(R-X)−E(R), where R is the unsubstituted system; X = NH2, NO2. Changes in the energy of the substituents, estimated for the benzene analog, Erel(X), allow the energy of the various substituents to be compared. The obtained values are interpreted through correlations with the geometry of the substituent and the substituted system. We show that Erel(X) is strongly dependent on the proximity of the substitution. Values of Erel(X) are also compared with a substituent descriptor based on atomic charge distribution–charge of the substituent active region, cSAR(X). It has been shown that these two descriptors correlate very well (R2 > 0.99); however, only for linear acenes with similar, “benzene-like” proximity. Moreover, relations between Erel(X) and cSAR(X), the geometry of the substituents, and angle at the ipso carbon atom can be explained by the well-established Bent–Walsh rule.
A Pragmatic Assessment of Google Translate for Emergency Department Instructions
Authors: Taira Breena R. , Kreger Vanessa , Orue Aristides , Diamond Lisa C. 
Published: March 2021

ABSTRACT
Background
Because many hospitals have no mechanism for written translation, ED providers resort to the use of automated translation software, such as Google Translate (GT) for patient instructions. A recent study of discharge instructions in Spanish and Chinese suggested that accuracy rates of Google Translate (GT) were high.

Study Objective
To perform a pragmatic assessment of GT for the written translation of commonly used ED discharge instructions in seven commonly spoken languages.

Methods
A prospective assessment of the accuracy of GT for 20 commonly used ED discharge instruction phrases, as evaluated by a convenience sample of native speakers of seven commonly spoken languages (Spanish, Chinese, Vietnamese, Tagalog, Korean, Armenian, and Farsi). Translations were evaluated using a previously validated matrix for scoring machine translation, containing 5-point Likert scales for fluency, adequacy, meaning, and severity, in addition to a dichotomous assessment of retention of the overall meaning.

Results
Twenty volunteers evaluated 400 google translated discharge statements. Volunteers were 50% female and spoke Spanish (5), Armenian (2), Chinese (3), Tagalog (4), Korean (2), and Farsi (2). The overall meaning was retained for 82.5% (330/400) of the translations. Spanish had the highest accuracy rate (94%), followed by Tagalog (90%), Korean (82.5%), Chinese (81.7%), Farsi (67.5%), and Armenian (55%). Mean Likert scores (on a 5-point scale) were high for fluency (4.2), adequacy (4.4), meaning (4.3), and severity (4.3) but also varied.

Conclusion
GT for discharge instructions in the ED is inconsistent between languages and should not be relied on for patient instructions.
Evaluation of plasma tau and neurofilament light chain biomarkers in a 12-year clinical cohort of human prion diseases
Authors: Thompson Andrew G. B. , Anastasiadis Prodromos , Druyeh Ronald , Whitworth Ines , Nayak Annapurna , Nihat Akin , Mok Tze How , Rudge Peter , Wadsworth Jonathan D. F. , Rohrer Jonathan , Schott Jonathan M. , Heslegrave Amanda , Zetterberg Henrik , Collinge John , Jackson Graham S. , Mead Simon 
Published: March 2021

AbstractPrion diseases are fatal neurodegenerative conditions with highly accurate CSF and imaging diagnostic tests, but major unmet needs for blood biomarkers. Using ultrasensitive immuno-assays, we measured tau and neurofilament light chain (NfL) protein concentrations in 709 plasma samples taken from 377 individuals with prion disease during a 12 year prospective clinical study, alongside healthy and neurological control groups. This provides an unprecedented opportunity to evaluate their potential as biomarkers. Plasma tau and NfL were increased across all prion disease types. For distinguishing sCJD from control groups including clinically-relevant “CJD mimics”, both show considerable diagnostic value. In sCJD, NfL was substantially elevated in every sample tested, including during early disease with minimal functional impairment and in all follow-up samples. Plasma tau was independently associated with rate of clinical progression in sCJD, while plasma NfL showed independent association with severity of functional impairment. In asymptomatic PRNP mutation carriers, plasma NfL was higher on average in samples taken within 2 years of symptom onset than in samples taken earlier. We present biomarker trajectories for nine mutation carriers healthy at enrolment who developed symptoms during follow-up. NfL started to rise as early as 2 years before onset in those with mutations typically associated with more slowly progressive clinical disease. This shows potential for plasma NfL as a “proximity marker”, but further work is needed to establish predictive value on an individual basis, and how this varies across different PRNP mutations. We conclude that plasma tau and NfL have potential to fill key unmet needs for biomarkers in prion disease: as a secondary outcome for clinical trials (NfL and tau); for predicting onset in at-risk individuals (NfL); and as an accessible test for earlier identification of patients that may have CJD and require more definitive tests (NfL). Further studies should evaluate their performance directly in these specific roles.
Palliative radiation therapy for symptomatic advance breast cancer
Authors: Jacobson Galia , Kaidar-Person Orit , Haisraely Ory , Galper Shira , Rabin Tatiana , Dromi Shahadi Ilanit , Lawrence Yaacov Richard , Symon Zvi , Akiva Ben-David Merav 
Published: March 2021

AbstractIn this study, we evaluated the effectiveness of palliative breast radiation therapy (RT), with single fraction RT compared with fractionated RT. Our study showed that both RT fractionation schemas provide palliation. Single fraction RT allowed for treatment with minimal interference with systemic therapy, whereas fractionated RT provided a more durable palliative response. Due to equivalent palliative response, at our institution we have increasingly been providing single fraction RT palliation during the COVID-19 pandemic.