bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closing the door to false memory: the effects of levels-of-processing and stimulus type on the rejection of perceptually vs. semantically dissimilar distractors
Authors: Nieznański Marek , Obidziński Michał 
Published: June 2021

AbstractFalse recognition memory for nonstudied items that share features with targets can be reduced by retrieval monitoring mechanisms. The recall-to-reject process, for example, involves the recollection of information about studied items that disqualifies inconsistent test probes. Monitoring for specific features during retrieval may be enhanced by an encoding orientation that is recapitulated during retrieval. In two experiments, we used concrete words or door scenes as materials and manipulated the level of processing at study and the type of distractors presented at test. We showed that for the verbal material, semantic level of processing at study results in an effective rejection of semantically inconsistent distractors. However, for the pictorial material, the perceptual level of processing leads to an effective rejection of perceptually inconsistent distractors. For targets, the effect of levels of processing was observed for words but not for pictures. The results suggest that retrieval monitoring mechanisms depend on interactions between encoding orientation, study materials, and differentiating features of distractors.
Survival predictors of 177Lu-Dotatate peptide receptor radionuclide therapy (PRRT) in patients with progressive well-differentiated neuroendocrine tumors (NETS)
Authors: Swiha Mina M. , Sutherland Duncan E. K. , Sistani Golmehr , Khatami Alireza , Abazid Rami M. , Mujoomdar Amol , Wiseman Daniele P. , Romsa Jonathan G. , Reid Robert H. , Laidley David T. 
Published: June 2021

Abstract
Purpose
177Lu-Dotatate is an emerging treatment modality for patients with unresectable or metastatic well-differentiated NETs. This study examines survival predictors in patients who received 177Lu-Dotatate.

Methods
A retrospective single-center review was conducted, examining 47 individuals with progressive well-differentiated NETs treated with 177Lu-Dotatate (four induction cycles of 5.5 GBq at 10-week intervals followed by eight maintenance cycles of 3.7 GBq at 6-month intervals).

Results
Median follow-up was 63.1 months with a median progression-free survival (PFS) of 34.1 months. However, median overall survival (OS) was not reached at the time of analysis. The presence of ≥ 5 bone metastases (hazard ratio HR 4.33; p = 0.015), non-gastroenteropancreatic (non-GEP) NETs (HR 3.22; p = 0.025) and development of interim ascites (HR 3.15; p = 0.047) independently predicted a worse OS. Patients with chromogranin A of ≥ 4 × upper limit of normal (ULN) had shorter OS (p < 0.001) and PFS (p = 0.004). Similarly, those with pre-existing ascites demonstrated a worse OS (p = 0.009) and PFS (p = 0.026). Liver metastases involving greater than 50% liver volume and the existence of unusual metastatic locations had a negative impact on OS (p = 0.033) and PFS (p = 0.026), respectively.

Conclusion
High burden of skeletal and hepatic metastases, non-GEP-NETs, chromogranin A of ≥ 4 × ULN, unusual metastatic sites, pre-existing and interim ascites are predictors of poor outcomes in patients treated with 177Lu-Dotatate. These common indicators can be used for the risk stratification and identification of patients most likely to benefit from PRRT.

Trial registration
ClinicalTrials.gov identifier: NCT02236910, Retrospectively registered on September, 2014.
3D mixed-reality visualization of medical imaging data as a supporting tool for innovative, minimally invasive surgery for gastrointestinal tumors and systemic treatment as a new path in personalized treatment of advanced cancer diseases
Authors: Wierzbicki Ryszard , Pawłowicz Maria , Job Józefa , Balawender Robert , Kostarczyk Wojciech , Stanuch Maciej , Janc Krzysztof , Skalski Andrzej 
Published: June 2021

Abstract
Background
The purpose of this study was to investigate the potential of a combination of 3D mixed-reality visualization of medical images using CarnaLife Holo (MedApp, Poland) system as a supporting tool for innovative, minimally invasive surgery/irreversible electroporation—IRA, Nano-Knife), microwave ablation (MWA)/for advanced gastrointestinal tumors. Eight liver and pancreatic tumor treatments were performed. In all of the patients undergoing laparoscopy or open surgery volume and margin were estimated by preoperative visualization. In all patients, neoplastic lesions were considered unresectable by standard methods.

Methods
Preoperative CT or MRI were transformed into holograms and displayed thanks to the HoloLens 2. During operation, the surgeon’s field of view was augmented with a 3D model of the patient’s relevant structures.

Results
The intraoperative hologram contributed to better presentation of tumor size and locations, more precise setting of needles used to irreversible electroporation and for determining ablation line in case of liver metastases. Surgeons could easily compare the real patient's anatomy to holographic visualization just before the operations.

Conclusions
The combination of 3D mixed-reality visualization using CarnaLife Holo with IRA, MWA and next systemic treatment (chemotherapy) might be a new way in personalized treatment of advanced cancers.
Culex quinquefasciatus (Diptera: Culicidae) survivorship following the ingestion of bird blood infected with Haemoproteus sp. parasites
Authors: Adams Dayvion R. , Golnar Andrew J. , Hamer Sarah A. , Slotman Michel A. , Hamer Gabriel L. 
Published: June 2021

AbstractArthropod vectors are frequently exposed to a diverse assemblage of parasites, but the consequence of these infections on their biology and behavior are poorly understood. We experimentally evaluated whether the ingestion of a common protozoan parasite of avian hosts (Haemoproteusspp.; Haemosporida: Haemoproteidae) impacted the survivorship ofCulex quinquefasciatus(Say) (Diptera: Culicidae). Blood was collected from wild northern cardinals (Cardinalis cardinalis) in College Station, Texas, and screened for the presence ofHaemoproteusspp. parasites using microscopic and molecular methods. Experimental groups ofCx. quinquefasciatusmosquitoes were offeredHaemoproteus-positive cardinal blood through an artificial feeding apparatus, while control groups receivedHaemoproteus-negative cardinal blood or domestic canary (Serinus canaria domestica) blood.Culex quinquefasciatusmosquitoes exposed toHaemoproteusinfected cardinal blood survived significantly fewer days than mosquitoes that ingestedHaemoproteus-negative cardinal blood. The survival of mosquitoes fed on positive cardinal blood had a median survival time of 18 days post-exposure and the survival of mosquitoes fed on negative cardinal blood exceeded 50% across the 30 day observation period. Additionally, mosquitoes that fed on canary controls survived significantly fewer days than cardinal negative controls, with canary control mosquitoes having a median survival time of 17 days. This study further supports prior observations thatHaemoproteusparasites can be pathogenic to bird-biting mosquitoes, and suggests thatHaemoproteusparasites may indirectly suppress the transmission of co-circulating vector-borne pathogens by modulating vector survivorship. Our results also suggest that even in the absence of parasite infection, bloodmeals from different bird species can influence mosquito survivorship.
Real-world safety and effectiveness of nivolumab for recurrent or metastatic head and neck cancer in Japan: a post-marketing surveillance
Authors: Tahara Makoto , Kiyota Naomi , Nibu Ken-ichi , Akamatsu Ayumi , Hoshino Tomohiro , Hayashi Ryuichi 
Published: June 2021

Abstract
Background
On the basis of phase III CheckMate 141 results, nivolumab was approved for recurrent or metastatic head and neck cancer after undergoing platinum-containing chemotherapy in Japan. This post-marketing surveillance aimed to evaluate the safety and effectiveness of nivolumab for head and neck cancer in the real-world setting.

Methods
All patients with head and neck cancer who planned to receive nivolumab were centrally registered. This study monitored 607 patients for 6 months to assess nivolumab’s safety, especially treatment-related adverse events (TRAEs) of special interest, and effectiveness.

Results
TRAEs occurred in 36.1% patients, with no new safety signals. The most common TRAEs with grade ≥ 3 were interstitial lung disease (1.2%), diarrhea (0.8%), and hepatic function abnormal (0.7%). Meanwhile, thyroid dysfunction (10.2%), hepatic dysfunction (5.3%), and interstitial lung disease (4.1%) were the most common TRAE categories of special interest. Although the median time to the onset of each TRAE category of special interest was mostly 1–2 months, most of them occurred throughout the observation period; nonetheless, the majority of patients recovered or remitted. The 6-month survival rate was 55.9%.

Conclusion
Japanese patients with head and neck cancer treated with nivolumab in the real-world setting manifested no new safety signals.

Clinical Trial Registration
clinicaltrials.jp: JapicCTI-184071.
The influence of standards and patents on long-term economic growth
Authors: Blind Knut , Ramel Florian , Rochell Charlotte 
Published: June 2021

AbstractFormal standards codify knowledge. Next to patents representing the generation of innovative knowledge, standards can hence be used to proxy the diffusion of innovative knowledge in macroeconomic growth models. Previous work mainly investigates the positive impact of in particular patents, but also standards on economic growth in short term, single country studies. This study is the first to examine the long-term effects of formal standards and patents on economic growth in a panel of eleven EU-15 countries between 1981 and 2014 using panel cointegration techniques. From policy makers' perspective standardization has also gained recently an increasing attention, e.g. in the call for the development of a European standardization strategy in the update of the industrial strategy. Our results show that European and international standards foster growth for the group of countries but that national standards have ambiguous growth effects in the panel. For patents, no significant effect on growth in this group of countries is identified.
On the applicability of viscosity-based capillary bundle concepts to predict the penetration behaviour of polymer solutions into sand
Authors: Verst Rowena , Lieske Wolfgang , Baille Wiebke , Pulsfort Matthias , Wichtmann Torsten 
Published: June 2021

AbstractThe increasing use of polymer solutions as support fluids in pile drilling, diaphragm walling or tunnelling applications demands a more detailed discussion of their penetration behaviour and prediction thereof. In this context, the capillary bundle approach can be a useful tool. However, while it is widely discussed in the oil and gas application, the subject is currently addressed only scarcely with regard to support fluid penetration targeting stagnation, where small flow velocities and non-cohesive soil environments are of relevance. In these boundary conditions, the applicability of capillary bundle approaches is not yet sufficiently confirmed and substantiated. The current paper thus reviews current capillary bundle models based on Hagen–Poiseuille in combination with a power-law rheological model and discusses their applicability with respect to support fluid application in the context of experimental soil permeation tests for small gradients ($$i\le 10$$

i
≤
10

). Two granular materials of similar grain size, but different angularity (glass beads and sand), and four polymer solutions varying in polymer chain length and concentration are investigated, and the impact of model assumptions and bulk material input variables is systematically discussed. The experimental results show that the theoretical models are generally able to predict the filter velocity qualitatively for values above $${\bar{v}}=5\times 10^{-7}$$

v

¯

=
5
×

10

-
7

m/s and also quantitatively, when an empirical shift factor $$\alpha ^*$$

α
∗

is introduced and water permeability values are determined experimentally. With respect to the influence of soil parameters, it was found that the soil particle roughness decreases the flow velocity of the polymer solution despite similar hydraulic conductivity in water. Polymer chain length and concentration were observed to control the degree of possible dilution ($$\alpha ^*<1$$

α
∗

<
1

) in the porous system compared to bulk rheological characteristics. It can therefore be concluded that capillary bundle models can indeed be applied in the targeted fields even though they are unable to predict a complete stagnation for $$i>0$$

i
>
0

. However, rather than specific model assumptions for tortuosity, taking into account the specific soil-polymer interaction has shown to be of primary importance to ensure no under- or over-prediction of penetration velocities solely based on bulk rheology.
Die Wirkung der Authentizität von Lernort und Laborgeräten auf das situationale Interesse und die Relevanzwahrnehmung beim Besuch eines naturwissenschaftlichen Schülerlabors
Authors: Schüttler Tobias , Watzka Bianca , Girwidz Raimund , Ertl Bernhard 
Published: June 2021

ZusammenfassungAls besonderes Merkmal von Schülerlaboren, die u. a. das Interesse an Naturwissenschaften fördern sollen, wird häufig die Authentizität der Lernumgebung genannt. Allerdings besteht Klärungsbedarf, welche Gestaltungsaspekte von authentischen Lernsettings interesseförderlich wirken. Die Faktoren Authentizität des Lernorts und Echtheit der Laborgeräte standen daher bei der hier beschriebenen quasi-experimentellen Interventionsstudie im 2 × 2-faktoriellen Design im Vordergrund. Untersucht wurde die Wirkung dieser Faktoren auf das situationale Interesse sowie auf die subjektiv wahrgenommene inhaltliche Relevanz und die wahrgenommene Authentizität der Laborgeräte beim Besuch eines forschungsnahen, naturwissenschaftlichen Schülerlabors. Dazu wurde ein Workshop zur Infrarotfernerkundung entwickelt und mit insgesamt 166 Schüler*innen der zehnten Klasse an unterschiedlich authentischen Lernorten (Schülerlabor vs. Schule) durchgeführt. Kontrastierend kamen an beiden Orten echte High-End-Laborgeräte, die im Allgemeinen nur Forschungseinrichtungen zur Verfügung stehen, bzw. vereinfachte, für Schulen verfügbare, weniger authentische Low-Cost-Geräte zum Einsatz. Die Arbeit mit den echten Laborgeräten führte unabhängig vom Lernort zu einer stärkeren Authentizitätswahrnehmung. Die Wahrnehmung inhaltlicher Relevanz hingegen war unabhängig von den Laborgeräten und wurde am authentischen Lernort signifikant höher bewertet als in der Schule. Das situationale epistemische Interesse war in der Gruppe am größten ausgeprägt, die am authentischen Lernort mit echten Laborgeräten arbeiten konnte.
Socio-economic impacts and challenges associated with the electrification of a remote area in rural Tanzania through a mini-grid system
Authors: Falk Joern , Angelmahr Martin , Schade Wolfgang , Schenk-Mathes Heike 
Published: June 2021

AbstractElectricity is an indispensable building block for sustainable development. As national and international electrification measures in rural areas of Tanzania are progressing slowly, a solar-powered mini-grid system with second-life battery storage was commissioned on an island in Lake Victoria in 2019 to support local development. This article evaluates the socio-economic impacts associated with electrification through this system. On average, 42.31 kWh of electricity could be provided per day. The daily demand of the main infrastructure (hospital and school) was 18.75 kWh on average. The remaining capacity thus offers enough potential to supply private households and possible economic activities. In order to evaluate the impact of electrification, a qualitative survey was conducted on site 12 months after commissioning, with 7% of the people living there being interviewed. Language barriers as well as intercultural hurdles made the survey difficult and required an adaptation of the on-site implementation. The focus of the survey was on the areas of health, education and economics. The study revealed that the availability of electricity has enormous potential to improve people's living conditions. Initial successes could be seen, especially in the areas of health care and the economic sector. So far, electrification has had no influence on the area of education. While the connections for the main infrastructure have been institutionally supported, the system-related electricity price of €1.30/kWh has proven to be a major obstacle for private households. This is far too high for widespread use compared to incomes. The article thus focuses on the observation that full socio-economic development through electrification can only succeed if local people can afford it. Possibilities to solve this problem are analysed. Since the energy is generated on the basis of renewable resources, the analysis focuses on the use of mechanisms of the emissions trading system (ETS). The aim is to generate revenue through the sale of certified emission reductions (CERs) for the saved CO2emissions and thus reduce the electricity price. A reference scenario of conventional energy production forms the basis for discussion of the effectiveness of the Clean Development Mechanism (CDM) and the Carbon Initiative for Development (Ci-Dev). In addition, the approach of a monthly free quota of electricity, the free basic electricity initiative (FBE), is included in the evaluation.Graphical abstract
Spatial and temporal variations of faecal indicator bacteria in Lake Bunyonyi, South-Western Uganda
Authors: Saturday Alex , Lyimo Thomas J. , Machiwa John , Pamba Siajali 
Published: June 2021

AbstractBackground Microbial water quality serves to indicate health risks associated with the consumption of contaminated water. Nevertheless, little is known about the microbiological characteristics of water in Lake Bunyonyi. This study was therefore undertaken to examine the spatial and temporal variations of faecal indicator bacteria (FIB) in relation to physicochemical parameters in Lake Bunyonyi. Result The FIB concentration was consistently measured during sampling months and correlated with each other showing the presumed human faecal pollution in the lake. The highest concentration values for E. coli (64.7 ± 47.3 CFU/100 mL) and enterococci (24.6 ± 32.4 CFU/100 mL were obtained in the station close to the Mugyera trading centre. On a temporal basis, the maximum values were recorded during the rainy season in October 2019 (70.7 ± 56.5 CFU/100 mL for E. coli and 38.44 ± 31.8 CFU/100 mL for enterococci. FIB did not differ significantly among the study stations (p > 0.05) but showed significant temporal variations among the months (p < 0.05) with concentrations being significantly high in wet season than dry season (U = 794, p < 0.0001 for E. coli; U = 993.5, p = 0.008 for enterococci). Spearman’s rank correlation revealed that FIB concentrations were significantly positively correlated with turbidity and DO concentration levels (p < 0.05). Approximately 97.2% of the water samples had E. coli and enterococci concentrations levels below USEPA threshold for recreational waters. Likewise, 98.1 and 90.7% of samples recorded E. coli and enterococci counts exceeding the UNBS, APHA, WHO and EU threshold values for drinking water. Conclusion The FIB counts show that the Lake Bunyonyi water is bacteriologically unsuitable for drinking unless it is treated since the FIB pose health risks to consumers. Besides, the water can be used for recreational purposes.
In-orbit results from the attitude determination and control system of ALSAT-2B
Authors: Benzeniar H. 
Published: June 2021

ABSTRACTThe Algerian Space Agency has been active in the field of microsatellite engineering for more than 15 years and has successfully developed microsatellites under several know-how transfer technology programs, six to date. This paper presents the flight results and lessons learned from the attitude determination and control system (ADCS) flown on the ALSAT-2B satellite, an Earth observation microsatellite, by analysing the behaviour of the satellite from the initial attitude acquisition through the coarse pointing mode then the nominal mode, where the payload is first tested, and finally the orbit control mode. The spacecraft was launched on 26 September 2016 and placed into a 670km Sun-synchronous orbit with a solar local time at an ascending node of 22:15. The ADCS performance presented here mainly focuses on the launch and early operation results. ALSAT-2B includes four reaction wheels in a pyramidal configuration, three gyros, three Sun sensors, three magneto-torquers, one magnetometer, and one star tracker for agile and accurate attitude control. In addition, a propulsion system based on four 1N hydrazine thrusters is also used on board the microsatellite. The main new development in this platform compared with previous ones of the same type is the fusion of the star tracker and measurements by the three gyroscopes into one gyrostellar estimator that was implemented for the first time on ALSAT-2B, and the pyramidal configuration of the wheels, aiming to increase the angular momentum. The results obtained from the early launch operations for different ADCS modes are very encouraging and fulfil all the requirements set during design and testing. Currently, the satellite has accomplished its fourth year in orbit and is still operational and producing high-quality images.
An Investigation Into the Influence of Positive Peer Feedback on Self-Relevant Cognitions in Social Anxiety
Authors: Miers Anne C. 
Published: June 2021

AbstractThis study investigated whether positive feedback from same-age peers can modify self-relevant cognitive processes of high socially anxious youth in a positive direction. Thirty-three high socially anxious and 32 non-socially anxious undergraduate students (17–22 years) gave an impromptu speech and received either positive or neutral feedback post-speech. Anticipatory processing (AP) was rated prior to the speech via self-report. One week later participants returned to the laboratory and completed questionnaires assessing post-event processing (PEP) thoughts related to the impromptu speech and AP about a future speech. For high socially anxious youth receiving positive feedback, AP about their speech performance significantly improved over time. In addition, high socially anxious participants who received positive feedback reported a higher frequency of positive PEP thoughts about their speech in the intervening week. These improvements did not occur in the neutral peer feedback condition. Non-socially anxious participants’ AP improved in both feedback conditions, whereas their frequency of PEP was unaffected by feedback. These findings suggest that, in high socially anxious youth, positive feedback from same-age peers can modify self-relevant cognitive processes in a positive direction. We discuss how methodological improvements could more thoroughly investigate the potential of positive peer feedback for changing cognitions.