bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine
Authors: Niazi Mostafa , Alizadeh Effat , Zarebkohan Amir , Seidi Khaled , Ayoubi‐Joshaghani Mohammad Hosein , Azizi Mehdi , Dadashi Hamed , Mahmudi Hossein , Javaheri Tahereh , Jaymand Mehdi , Hamblin Michael R. , Jahanban‐Esfahlan Rana , Amoozgar Zohreh 
Published: July 2021

AbstractAdvanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single‐cell approaches, capturing, analysis, and release of living cells, biomimetics of cell, tissue, and tumor‐specific niches. They can allow in vivo cell manipulation and act as novel drug delivery systems, allowing diagnostic, therapeutic, vaccination, and immunotherapy methods. In the present review of multitasking hydrogels, new approaches and devices classified into point‐of‐care testing (POCT), microarrays, single‐cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches are summarized. The potentials and application of each format are critically discussed, and some limitations are highlighted. Finally, how hydrogels can enable an “all‐in‐one platform” to play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases is being looked forward to.
Divalent Ion Selectivity in Capacitive Deionization with Vanadium Hexacyanoferrate: Experiments and Quantum‐Chemical Computations
Authors: Singh Kaustub , Li Guanna , Lee Juhan , Zuilhof Han , Mehdi B. Layla , Zornitta Rafael L. , de Smet Louis C. P. M. 
Published: July 2021

AbstractSelective removal of ions from water via capacitive deionization (CDI) is relevant for environmental and industrial applications like water purification, softening, and resource recovery. Prussian blue analogs (PBAs) are proposed as an electrode material for selectively removing cations from water, based on their size. So far, PBAs used in CDI are selective toward monovalent ions. Here, vanadium hexacyanoferrate (VHCF), a PBA, is introduced as a new electrode material in a hybrid CDI setup to selectively remove divalent cations from water. These electrodes prefer divalent Ca2+ over monovalent Na+, with a separation factor, βCa/Na ≈3.5. This finding contrasts with the observed monovalent ion selectivity by PBA electrodes. This opposite behavior is understood by density functional theory simulations. Furthermore, coating the VHCF electrodes with a conducting polymer (poly‐pyrrole, doped with poly‐styrenesulphonate) prevents the contamination of the treated water following the degradation of the electrode. This facile and modular coating method can be effortlessly extended to other PBA electrodes, limiting the extent of treated water contamination during repeated cycling. This study paves the way for tunable selectivity while extending the library of electrodes that can be successfully used in (selective) CDI.
Systematic Design and Demonstration of Multi‐Bit Generation in Layered Materials Heterostructures Floating‐Gate Memory
Authors: Gwon Oh Hun , Kim Jong Yun , Kim Han Seul , Kang Seok‐Ju , Byun Hye Ryung , Park Min , Lee Dong Su , Kim Yoon‐jeong , Ahn Seokhoon , Kim Jaekyung , Cho Sang‐Joon , Yu Young‐Jun 
Published: July 2021

AbstractVan der Waals (vdW) heterostructures with 2D materials have shown that atomically thin non‐volatile memories are advantageous in terms of integration, while offering high performance and excellent stability. The non‐volatile memory behavior of 2D materials has mainly been studied for single‐bit operation, and there is growing interest in expanding to multi‐bit operation to enhance the storage capacities of memory devices. However, the conditions or rules for generating the desired number of bits in 2D‐based multi‐bit memory remain to be identified. In this study, multiple bits are successfully created on non‐volatile memory based on vdW heterostructure floating‐gate memory (FGM) by systematically tuning the dimensions of the 2D materials. In particular, a fingerprint mechanism is established that links the bit number and dimensions of 2D crystals on vdW heterostructures. This approach could enable the precise generation of the desired number of bits in layered‐material‐based vdW FGMs.
A Smartphone‐Enabled Portable Digital Light Processing 3D Printer
Authors: Li Wanlu , Wang Mian , Mille Luis Santiago , Robledo Lara Juan Antonio , Huerta Valentín , Uribe Velázquez Tlalli , Cheng Feng , Li Hongbin , Gong Jiaxing , Ching Terry , Murphy Caroline A. , Lesha Ami , Hassan Shabir , Woodfield Tim B. F. , Lim Khoon S. , Zhang Yu Shrike 
Published: July 2021

Abstract3D printing has emerged as an enabling approach in a variety of different fields. However, the bulk volume of printing systems limits the expansion of their applications. In this study, a portable 3D Digital Light Processing (DLP) printer is built based on a smartphone‐powered projector and a custom‐written smartphone‐operated app. Constructs with detailed surface architectures, porous features, or hollow structures, as well as sophisticated tissue analogs, are successfully printed using this platform, by utilizing commercial resins as well as a range of hydrogel‐based inks, including poly(ethylene glycol)‐diacrylate, gelatin methacryloyl, or allylated gelatin. Moreover, due to the portability of the unique DLP printer, medical implants can be fabricated for point‐of‐care usage, and cell‐laden tissues can be produced in situ, achieving a new milestone for mobile‐health technologies. Additionally, the all‐in‐one printing system described herein enables the integration of the 3D scanning smartphone app to obtain object‐derived 3D digital models for subsequent printing. Along with further developments, this portable, modular, and easy‐to‐use smartphone‐enabled DLP printer is anticipated to secure exciting opportunities for applications in resource‐limited and point‐of‐care settings not only in biomedicine but also for home and educational purposes.
Plasmon‐Driven Catalytic Chemotherapy Augments Cancer Immunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway
Authors: Ding Yuan , Sun Zhongquan , Gao Yong , Zhang Sitong , Yang Caixia , Qian Zhefeng , Jin Lulu , Zhang Jiaojiao , Zeng Cheng , Mao Zhengwei , Wang Weilin 
Published: July 2021

AbstractClinical trials confirm the combination of indoleamine 2,3‐dioxygenase (IDO) blockade and immunogenic chemotherapy represents a brilliant future in cancer therapy. However, it remains challenging to precisely activate chemo‐immunotherapy in situ to avoid side effects from the systemic administrations and reverse the poor immunogenicity and immunosuppressive microenvironment in tumor sites. Herein, a hybrid nanomedicine (“RPMANB NPs”) to co‐deliver an IDO inhibitor (NLG919) and a chemotherapeutic prodrug to amplify the therapeutic benefits are designed. Attributed to the delicate surface engineering, the RPMANB NPs possess excellent pharmacokinetics and tumor accumulation. The loaded NLG919 are released inside cancer tissues/cells due to the collapse of the metal–organic framework platform triggered by the highly concentrated phosphate, reversing the immunosuppressive tumor microenvironment by suppressing IDO activity. The potent chemotherapeutic drug is precisely activated through a highly efficient plasmon‐driven catalysis in the presence of near‐infrared light, eliciting antitumor immunity by triggering immunogenic cell death and avoiding side effects through in situ activation of chemotherapy. In vivo studies demonstrate that the chemo‐immunotherapy greatly suppresses the tumor growth by promoting intratumoral accumulation of cytotoxic T lymphocytes and downregulating regulatory T cells. This work establishes a robust delivery platform to overcome the current obstacles of tumor treatments by combining precisely activatable chemotherapy with immunotherapy.
Polymer‐Assisted Metallization of Mammalian Cells
Authors: Wang Wenshuo , Gan Qi , Zhang Yuqi , Lu Xi , Wang Huixin , Zhang Yaokang , Hu Hong , Chen Lina , Shi Lianxin , Wang Shutao , Zheng Zijian 
Published: July 2021

AbstractDeveloping biotemplating techniques to translate microorganisms and cultured mammalian cells into metallic biocomposites is of great interest for biosensors, electronics, and energy. The metallization of viruses and microbial cells is successfully demonstrated via a genetic engineering strategy or electroless deposition. However, it is difficult to transform mammalian cells into metallic biocomposites because of the complicated genes and the delicate morphological features. Herein, “polymer‐assisted cell metallization” (PACM) is reported as a general method for the transformation of mammalian cells into metallic biocomposites. PACM includes a first step of in situ polymerization of functional polymer on the surface and in the interior of the mammalian cells, and a subsequent electroless deposition of metal to convert the polymer‐functionalized cells into metallic biocomposites, which retain the micro‐ and nanostructures of the mammalian cells. This new biotemplating method is compatible with different cell types and metals to yield a wide variety of metallic biocomposites with controlled structures and properties.
Site‐Specific Biomimicry of Antioxidative Melanin Formation and Its Application for Acute Liver Injury Therapy and Imaging
Authors: Zhao Caiyan , Li Zhi , Chen Jingxiao , Su Lichao , Wang Junqing , Chen Dean Shuailin , Ye Jiamin , Liao Naishun , Yang Huanghao , Song Jibin , Shi Jinjun 
Published: July 2021

AbstractBiocompatible nano‐antioxidants composed of natural molecules/materials, such as dopamine and melanin, are of great interest for diverse biomedical applications. However, the lack of understanding of the precise structure of these biomaterials and thus the actual dose of effective components impedes their advancement to translation. Herein, a strategy to mimic in situ melanin formation and explore its antioxidative applications is reported, by developing a PEGylated, phenylboronic‐acid‐protected L‐DOPA precursor (PAD) that can self‐assemble into well‐defined nanoparticles (PADN). Exposure to oxidative species leads to deprotection of phenylboronic acids, transforming PADN to PEG‐L‐DOPA, which, similar to the biosynthetic pathway of melanin, can be oxidized and polymerized into an antioxidative melanin‐like structure. With ultrahigh stability and superior antioxidative activity, the PADN shows remarkable efficacy in prevention and treatment of acute liver injury/failure. Moreover, the in situ structure transformation enables PADN to visualize damaged tissue noninvasively by photoacoustic imaging. Overall, a bioinspired antioxidant with precise structure and site‐specific biological activity for theranostics of oxidative stress‐related diseases is described.
Autonomous Off‐Equilibrium Morphing Pathways of a Supramolecular Shape‐Memory Polymer
Authors: Peng Wenjun , Zhang Guogao , Zhao Qian , Xie Tao 
Published: July 2021

AbstractThe diverse morphing behaviors of living creatures arise from their unlimited pathways. In contrast, the equilibrium‐driven morphing pathways of common synthetic shape‐shifting materials are very limited. For a shape‐memory polymer (SMP), its recovery from the temporary shape(s) to the permanent shape typically requires external stimulation and follows a single fixed route. Herein, a covalently crosslinked SMP is designed with ample ureidopyrimidinone (UPy) supramolecular moieties in the network. The UPy units endow the SMP with strong time–temperature dependency, which is explored as a mechanism for spatio‐temporal programming of autonomous shape‐shifting pathways. In particular, the use of digitally controlled photothermal heating provides versatility in control via an off‐equilibrium mechanism. In addition, cooling/heating across its glass transition introduces a locking/unlocking mechanism for its temporal morphing. The benefits of these unique features are demonstrated by multi‐shape‐transformation, an “invisible”‐color‐based clock, a time–temperature indicator, and sequence‐programmable 4D printing.
Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner
Authors: Guo Jianping , Cheng Ji , Zheng Nana , Zhang Xiaomei , Dai Xiaoming , Zhang Linli , Hu Changjiang , Wu Xueji , Jiang Qiwei , Wu Depei , Okada Hitoshi , Pandolfi Pier Paolo , Wei Wenyi 
Published: July 2021

AbstractCopper plays pivotal roles in metabolic homoeostasis, but its potential role in human tumorigenesis is not well defined. Here, it is revealed that copper activates the phosphoinositide 3‐kinase (PI3K)‐protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to facilitate tumorigenesis. Mechanistically, copper binds 3‐phosphoinositide dependent protein kinase 1 (PDK1), in turn promotes PDK1 binding and subsequently activates its downstream substrate AKT to facilitate tumorigenesis. Blocking the copper transporter 1 (CTR1)‐copper axis by either depleting CTR1 or through the use of copper chelators diminishes the AKT signaling and reduces tumorigenesis. In support of an oncogenic role for CTR1, the authors find that CTR1 is abnormally elevated in breast cancer, and is subjected by NEDD4 like E3 ubiquitin protein ligase (Nedd4l)‐mediated negative regulation through ubiquitination and subsequent degradation. Accordingly, Nedd4l displays a tumor suppressive function by suppressing the CTR1‐AKT signaling. Thus, the findings identify a novel regulatory crosstalk between the Nedd4l‐CTR1‐copper axis and the PDK1‐AKT oncogenic signaling, and highlight the therapeutic relevance of targeting the CTR1‐copper node for the treatment of hyperactive AKT‐driven cancers.
A comprehensive phylogenomic study of the monocot order Commelinales, with a new classification of Commelinaceae
Authors: Zuntini Alexandre R. , Frankel Lorna P. , Pokorny Lisa , Forest Félix , Baker William J. 
Published: July 2021

PremiseResolving relationships within order Commelinales has posed quite a challenge, as reflected in its unstable infra‐familial classification. Thus, we investigated (1) relationships across families and genera of Commelinales; (2) phylogenetic placement of never‐before sequenced genera; (3) how well off‐target plastid data integrate with other plastid‐based data sets; and (4) how the novel inferences coincide with the infra‐familial classification.MethodsWe generated two large data sets (nuclear and plastome) by means of target sequence capture using the Angiosperms353 probe set, with additional sequences mined from publicly available transcriptomes and full plastomes. A third extended‐plastid data set was considered, including all species with sequences in public repositories. Species trees were inferred under a multispecies coalescent framework from individual gene trees and also using maximum likelihood analyses from concatenated and partitioned data.ResultsThe nuclear, plastome, and extended‐plastid data sets include 52, 53, and 58 genera, respectively, and up to 290 species of Commelinales, representing the most comprehensive molecular sampling for the order to date, which includes seven never‐before sequenced genera.ConclusionsWe inferred robust phylogenies supporting the monophyly of Commelinales and its five constituent families, and we recovered the clades Pontederiaceae‐Haemodoraceae and Hanguanaceae‐Commelinaceae, as previously reported. The placement of Philydraceae remains contentious. Relationships within the two largest families, Commelinaceae and Haemodoraceae, are resolved. Based on the latter results, we confirm the subfamilial classification of Haemodoraceae and propose a new classification for Commelinaceae, which includes the synonymization of Tapheocarpa in Commelina.
Technique for ultrasound‐guided radiofrequency denervation of genicular nerves for chronic knee pain
Authors: Merrin Elizabeth , Grimshaw Le‐Anne 
Published: July 2021

AbstractGenicular nerve radiofrequency denervation (GNRFD), also called radiofrequency ablation or genicular neurotomy, has been demonstrated to be a safe and effective method of treating and managing chronic knee pain caused by osteoarthritis (OA). The genicular nerves have been identified as key sensory nerves that innervate the knee joint. Using ultrasound guidance, the genicular nerves can be heated to temperatures up to 80°C, creating a local neuronal lesion, causing denervation and therefore temporarily alleviating knee pain. GNRFD is an effective treatment for those with chronic knee pain in whom conservative treatment has failed, who are poor candidates for surgery or who are on an extended waiting list for their surgery. This article outlines the technique for introducing the radiofrequency (RF) probes so the tip is in close proximity to the genicular nerves using ultrasound guidance.
Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo‐ and Enantioselective Oxidative 1,6‐Conjugate Addition
Authors: Liu Xigong , Zhao Changyin , Zhu Rongxiu , Liu Lei 
Published: July 2021

AbstractThe asymmetric construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. We disclose a solution involving diastereo‐ and enantioselective oxidative 1,6‐conjugate addition. The practical asymmetric cross‐dehydrogenative coupling of 2,2‐diarylacetonitriles and diverse α‐substituted cyclic 1,3‐dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach is further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β‐ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo‐ and enantioselectivity.
Exquisite Vesicular Nanomedicine by Paclitaxel Mediated Co‐assembly with Camptothecin Prodrug
Authors: Zhou Zijian , Du Chao , Zhang Qianyu , Yu Guocan , Zhang Fuwu , Chen Xiaoyuan 
Published: July 2021

AbstractWe report that the self‐assembly of drug amphiphiles, Evans blue conjugated camptothecin prodrug (EB‐CPT), can be modulated by another anticancer drug paclitaxel (PTX), resulting in ultrahigh quality of nanovesicles (NVs) with uniform shape and diameters of around 80 nm with the EB‐CPT:PTX weight ratio of 1:1, 1:2, and 1:3, denoted as ECX NVs. Significantly, the co‐assembly of EB‐CPT and PTX without adding other excipients has nearly 100 % drug loading efficiency (DLE) and ultrahigh drug loading content (DLC) of PTX alone of up to 72.3±1.7 wt % which, to our best knowledge, is among the highest level reported in literature. Moreover, the ECX NVs with the EB‐CPT:PTX weight ratio of 1:2 showed remarkable combination index of 0.59 at a level of 50 % efficacy against HCT116 cells in vitro and greatly improved tumor inhibition effect in vivo compared with two clinically approved CPT‐ and PTX‐based anticancer nanomedicines (Onivyde and Abraxane) individually and their combinations.
Molecular Tailoring of an n/p‐type Phenothiazine Organic Scaffold for Zinc Batteries
Authors: Wang Nan , Guo Zhaowei , Ni Zhigang , Xu Jie , Qiu Xuan , Ma Jing , Wei Peng , Wang Yonggang 
Published: July 2021

AbstractThe p‐type or n‐type redox reactions of organics are being used as the reversible electrodes to build the next‐generation rechargeable batteries with sustainable and tunable characteristics. However, the n‐type organics that store cations generally exhibit low potential (<0.8 V vs. Zn/Zn2+), while the p‐type organics that store anions suffer from limited capacity (<100 mAh g−1). Herein, we demonstrate that bis(phenylamino)phenothiazin‐5‐ium iodide (PTD‐1) containing both n‐type and p‐type redox moieties exhibits a hybrid charge storage mechanism (n/p‐type at low potential, p‐type at high potential). Such a hybrid mechanism combines the advantages of n‐ and p‐type reactions and compensates for the associated drawbacks of each. Accordingly, the aqueous Zn//PTD‐1 full cell shows a high voltage (1.8 Vmaximum or 1.1 Vaverage), a high capacity 188.24 mAh gPTD‐1−1 (achieved at 40 mA g−1), a long‐life and a supercapacitor‐like high power. These results shed new light on the design of advanced organic electrodes.
Electrical and mechanical properties of partially bio‐based PP/PBS blends nanocomposites elaborated by twin‐screw extrusion
Authors: Bencharki Mouhja , Rondot Sébastien , Tara Ahmed , Jbara Omar , Berzin Françoise 
Published: July 2021

AbstractOrganically modified montmorillonite (OMMT, Cloisite 20) was used as reinforcing filler to prepare nanocomposites from a blend of polypropylene (PP) and eco‐friendly degradable polybutylene succinate (PBS). A PP grafted with maleic anhydride was also added as a compatibilizer. Scanning electron microscopy observations indicated that the blend morphology was affected by the presence of OMMT, which acted as a compatibilizer between PP and PBS. Rheological measurements showed a significant increase of the complex viscosity when OMMT was added above a certain amount. X‐ray diffraction indicated an intercalated structure for all nanocomposites. The addition of OMMT improved mechanical properties of neat matrices and blends. The electrical insulation properties were preserved for low concentrations of OMMT, up to 2 wt%. Then, to guarantee good mechanical properties without deteriorating electrical ones, while maintaining a sufficient bio‐based composition, the 70/30 (PP/PBS) blend with clay concentrations of less than 2 wt% appeared to be the most satisfactory nanocomposite for applications in the field of electrical insulation.
Hydrophobically modified melamine‐formaldehyde sponge used for conformance control and water shutoff during oil production
Authors: Ou Wen , Luo Xinjie , Feng Yujun 
Published: July 2021

AbstractPolymer or polymer gels have been widely used to control excessive water during oil production by homogenizing injection profile and reducing water cut in the produced fluids. However, the gels used are generally unable to selectively minimize water production, and face the challenge of syneresis of gels under high temperature and high salinity environment. In this work, melamine‐formaldehyde sponge was modified with AlCl3 solution, rendering a transition from hydrophilic to hydrophobic state with a water contact angle of 130° on the surface of the modified product. Filtration results show that mineral oil and water can be selectively separated with the hydrophobically modified sponge powders. Simulated water shutoff experiments demonstrated the blockage efficiency against water was 30% higher than that against oil, and the oil production was increased 7.4% after blocking. The parallel profile control tests confirmed that the fraction flow of high permeable channel decreased about 75%, accompanied with 60% rise of oil recovery factor. These results indicated that such hydrophobic materials can significantly reduce excessive water production, and this work provided a new idea to offer a low‐cost hydrophobic material for conformance control and water shutoff during oil production.