bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural history and mechanisms of COPD
Authors: Lange Peter , Ahmed Engi , Lahmar Zakaria Mohamed , Martinez Fernando J. , Bourdin Arnaud 
Published: January 2021

ABSTRACTThe natural history of COPD is complex, and the disease is best understood as a syndrome resulting from numerous interacting factors throughout the life cycle with smoking being the strongest inciting feature. Unfortunately, diagnosis is often delayed with several longitudinal cohort studies shedding light on the long ‘preclinical’ period of COPD. It is now accepted that individuals presenting with different COPD phenotypes may experience varying natural history of their disease. This includes its inception, early stages and progression to established disease. Several scenarios regarding lung function course are possible, but it may conceptually be helpful to distinguish between individuals with normal maximally attained lung function in their early adulthood who thereafter experience faster than normal FEV1 decline, and those who may achieve a lower than normal maximally attained lung function. This may be the main mechanism behind COPD in the latter group, as the decline in FEV1 during their adult life may be normal or only slightly faster than normal. Regardless of the FEV1 trajectory, continuous smoking is strongly associated with disease progression, development of structural lung disease and poor prognosis. In developing countries, factors such as exposure to biomass and sequelae after tuberculosis may lead to a more airway‐centred COPD phenotype than seen in smokers. Mechanistically, COPD is characterized by a combination of structural and inflammatory changes. It is unlikely that all patients share the same individual or combined mechanisms given the heterogeneity of resultant phenotypes. Lung explants, bronchial biopsies and other tissue studies have revealed important features. At the small airway level, progression of COPD is clinically imperceptible, and the pathological course of the disease is poorly described. Asthmatic features can further add confusion. However, the small airway epithelium is likely to represent a key focus of the disease, combining impaired subepithelial crosstalk and structural/inflammatory changes. Insufficient resolution of inflammatory processes may facilitate these changes. Pathologically, epithelial metaplasia, inversion of the goblet to ciliated cell ratio, enlargement of the submucosal glands and neutrophil and CD8‐T‐cell infiltration can be detected. Evidence of type 2 inflammation is gaining interest in the light of new therapeutic agents. Alarmin biology is a promising area that may permit control of inflammation and partial reversal of structural changes in COPD. Here, we review the latest work describing the development and progression of COPD with a focus on lung function trajectories, exacerbations and survival. We also review mechanisms focusing on epithelial changes associated with COPD and lack of resolution characterizing the underlying inflammatory processes.
Renewing the Auld Alliance: Marie Stuart’s poetics and the Catholic League’s politics☆
Authors: DeVos Jessica Erin 
Published: January 2021

AbstractFew historical sovereigns’ political fate and posthumous image have been as influenced by creative literature as those of Marie, Queen of Scots, yet comparatively little attention has been paid to how she depicted herself in her own poetry. Most research devoted to her verse over the past two decades has been undertaken by scholars of English literature, despite the fact that Marie Stuart was neither English, nor did she write poetry in that language. Acknowledging that Marie considered France her homeland and French her mother tongue, this article examines the poems contained in Oxford MS. Add C.92, fol.22 as works of Francophone literature and situates them within a transnational historical context that has also been understudied: the intersection of the English Catholic exile cause in Paris with the politics and propaganda of France’s Catholic League, led by Marie’s cousin, Henri, Duke of Guise. It seeks to clarify not only the language and meaning of the poems themselves, but also to highlight how they draw from and contribute to a larger pool of French poetic and political discourse during the French Wars of Religion.
Trends and applications in plant volatile sampling and analysis
Authors: Tholl Dorothea , Hossain Oindrila , Weinhold Alexander , Röse Ursula S. R. , Wei Qingshan 
Published: January 2021

SUMMARYVolatile organic compounds (VOCs) released by plants serve as information and defense chemicals in mutualistic and antagonistic interactions and mitigate effects of abiotic stress. Passive and dynamic sampling techniques combined with gas chromatography–mass spectrometry analysis have become routine tools to measure emissions of VOCs and determine their various functions. More recently, knowledge of the roles of plant VOCs in the aboveground environment has led to the exploration of similar functions in the soil and rhizosphere. Moreover, VOC patterns have been recognized as sensitive and time‐dependent markers of biotic and abiotic stress. This focused review addresses these developments by presenting recent progress in VOC sampling and analysis. We show advances in the use of small, inexpensive sampling devices and describe methods to monitor plant VOC emissions in the belowground environment. We further address latest trends in real‐time measurements of volatilomes in plant phenotyping and most recent developments of small portable devices and VOC sensors for non‐invasive VOC fingerprinting of plant disease. These technologies allow for innovative approaches to study plant VOC biology and application in agriculture.
ACOUSTICAL STANDARDS NEWS
Authors: Blair-DeLeon Nancy A. , Struck Christopher J. 
Published: January 2021

American National Standards (ANSI Standards) developed by Accredited Standards Committees S1, S2, S3, S3/SC 1, and S12 in the areas of acoustics, mechanical vibration and shock, bioacoustics, animal bioacoustics, and noise, respectively, are published by the Acoustical Society of America (ASA). In addition to these standards, ASA publishes a catalog of Acoustical American National Standards. To browse the latest copy of our catalog, visit our website at https://acousticalsociety.org/download-catalog/.
Comments are welcomed on all material in Acoustical Standards News.
This Acoustical Standards News section in JASA, as well as the National Catalog of Acoustical Standards and other information on the Standards Program of the Acoustical Society of America, are also available via the ASA Standards home page: https://acousticalsociety.org/acoustical-society-standards/.
Are There Associations Between Submaximal and Maximal Aerobic Power and International Ski Federation World Cup Ranking in Elite Alpine Skiers?
Authors: Schobersberger Wolfgang , Mairhofer Michael , Haslinger Simon , Koller Arnold , Raschner Christian , Puntscher Sibylle , Blank Cornelia 
Published: January 2021

Purpose: To analyze the predictive value of parameters of submaximal and maximal cardiopulmonary exercise performance on International Ski Federation (Fédération Internationale de Ski) World Cup ranking (FIS ranking) in elite Austrian Alpine skiers. Methods: Over 7 World Cup seasons (2012–2018), exercise data (maximal oxygen uptake and maximum power output, lactate threshold 2, and ventilatory threshold 2, based on stepwise cycle spiroergometry) were analyzed to determine whether there was a correlation between world FIS ranking and exercise capacity of male and female elite Alpine skiers. Results: The data of 39 male skiers (age: 27.67 [4.20] y, body mass index: 26.03 [1.25] kg/m2) and 36 female skiers (age: 25.49 [3.18] y, body mass index: 22.97 [1.71] kg/m2) were included in this study. The maximum oxygen uptake and maximum power output ranged from 4.37 to 4.42 W/kg and 53.41 to 54.85 mL/kg/min in men and from 4.17 to 4.30 W/kg and 45.96 to 49.16 mL/kg/min in women, respectively, over the 7 seasons; the yearly mean FIS ranking ranged from 17 to 24 in men and 9 to 18 in women. In a fixed-effects model used for the subsequent panel regression analysis, no statistically significant effect on FIS ranking was found for the exercise parameters of interest. Conclusions: Neither maximal aerobic tests nor maximum power output significantly predicted competitive performance, as indexed by the FIS ranking. This reinforces the assumption that no single parameter determines competition performance in this complex sport. Therefore, identifying the optimum amount of endurance training remains a major challenge for athletes and coaches, as does identifying and improving the factors that determine performance.
Effects of Presession Well-Being Perception on Internal Training Load in Female Volleyball Players
Authors: Ungureanu Alexandru Nicolae , Brustio Paolo Riccardo , Boccia Gennaro , Rainoldi Alberto , Lupo Corrado 
Published: January 2021

Purpose: To evaluate if the internal training load (ITL; Edwards heart rate [HR]-based and session-rating of perceived exertion [RPE] methods) is affected by the presession well-being perception, age, and position in elite (ie, Serie A2) female volleyball training. Methods: Twelve female elite volleyball players (age: 22 [4] y, height: 1.80 [0.06] m, body mass: 74.1 [4.3] kg) were monitored using an HR monitor during 32 team training sessions (duration: 1:36:12 [0:22:24], in h:min:s). Linear mixed-effects models were applied to evaluate if well-being perception (ie, perceived sleep quality/disorders, stress level, fatigue, and delayed-onset muscle soreness) may affect ITL depending on age and tactical position. Results: Presession perceived fatigue influenced ITL according to the session-RPE (P = .032) but not according to the Edwards method. Age was inversely correlated to the Edwards method (P < .001) and directly correlated to the session-RPE (P = .027). Finally, central blockers experienced a higher training load than hitters (P < .001) and liberos (P < .001) for the Edwards method, as well as higher than hitters (P < .001), liberos (P = .003), and setters (P = .008) for session-RPE. Conclusions: Findings indicated that female volleyball players’ perceived ITL is influenced by presession well-being status, age, and position. Therefore, coaches can benefit from this information to specifically predict players’ ITL in relation to their individual characteristics.
Objectively Measured Sedentary Behavior and Physical Activity Across 3 Trimesters of Pregnancy: The Monitoring Movement and Health Study
Authors: Barone Gibbs Bethany , Jones Melissa A. , Jakicic John M. , Jeyabalan Arun , Whitaker Kara M. , Catov Janet M. 
Published: January 2021

Background: Though moderate- to vigorous-intensity physical activity is recommended, limited research exists on sedentary behavior (SED) during pregnancy. Methods: The authors conducted a prospective cohort study to describe objectively measured patterns of SED and activity during each trimester of pregnancy. Women wore thigh- (activPAL3) and waist-mounted (ActiGraph GT3X) activity monitors. SED and activity were compared across trimesters using likelihood ratio tests and described using group-based trajectories. Exploratory analyses associated SED and activity trajectories with adverse pregnancy outcomes and excessive gestational weight gain. Results: Pregnant women (n = 105; mean [SD] age = 31 [5] y; prepregnancy body mass index = 26.2 [6.6] kg/m2) had mean SED of 9.7, 9.5, and 9.5 hours per day (P = .062) across trimesters, respectively. Some activities differed across trimesters: standing (increased, P = .01), stepping (highest in second trimester, P = .04), steps per day (highest in second trimester, P = .008), and moderate- to vigorous-intensity physical activity (decreased, P < .001). Prolonged SED (bouts ≥ 30 min) and bouted moderate- to vigorous-intensity physical activity (≥10 min) were stable (P > .05). In exploratory analyses, higher SED and lower standing, stepping, and steps per day trajectories were associated with increased odds of adverse pregnancy outcomes (P < .05). No trajectories were associated with excessive gestational weight gain. Conclusions: Pregnant women exhibited stable SED of nearly 10 hours per day across pregnancy. Future research evaluating SED across pregnancy and adverse pregnancy outcome risk is warranted.
Antibiotic-Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty: A Register-based Multicentre Randomised Controlled Non-inferiority Trial (ALBA trial)
Authors: Leta Tesfaye H , Gjertsen Jan-Erik , Dale Håvard , Hallan Geir , Lygre Stein Håkon Låstad , Fenstad Anne Marie , Dyrhovden Gro Sævik , Westberg Marianne , Wik Tina Stromdal , Jakobsen Rune Bruhn , Aamodt Arild , Röhrl Stephan Maximillian , Gøthesen Øystein Johannes , Lindalen Einar , Heir Stig , Ludvigsen Jarle , Bruun Trond , Hansen Ann Kristin , Aune Knut Erik Moen , Warholm Marianne , Skjetne John Petter , Badawy Mona , Høvding Pål , Husby Otto Schnell , Karlsen Øystein Espeland , Furnes Ove 
Published: January 2021

IntroductionThe current evidence on the efficacy of antibiotic-loaded bone cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient. In several European countries, the use of ALBC is routine practice unlike in the USA where ALBC use is not approved in low-risk patients. Therefore, we designed a double-blinded pragmatic multicentre register-based randomised controlled non-inferiority trial to investigate the effects of ALBC compared with plain bone cement in primary total knee arthroplasty (TKA).Methods and analysisA minimum of 9,172 patients undergoing full-cemented primary TKA will be recruited and equally randomised into the ALBC group and the plain bone cement group. This trial will be conducted in Norwegian hospitals that routinely perform cemented primary TKA. The primary outcome will be risk of revision surgery due to PJI at 1-year of follow-up. Secondary outcomes will be: risk of revision due to any reason including aseptic loosening at 1, 6, 10 and 20 years of follow-up; patient-related outcome measures like function, pain, satisfaction and health-related quality of life at 1, 6 and 10 years of follow-up; risk of changes in the microbial pattern and resistance profiles of organisms cultured in subsequent revisions at 1, 6, 10 and 20 years of follow-up; cost-effectiveness of routine ALBC versus plain bone cement use in primary TKA. We will use 1:1 randomisation with random permuted blocks and stratify by participating hospitals to randomise patients to receive ALBC or plain bone cement. Inclusion, randomisation and follow-up will be through the Norwegian Arthroplasty Register.Ethics and disseminationThe trial was approved by the Western Norway Regional Committees on Medical and Health Research Ethics (reference number: 2019/751/REK vest) on 21 June 2019. The findings of this trial will be disseminated through peer-reviewed publications and conference presentations.Trial registration numberNCT04135170.
Protocol for the Stather Canadian Outcomes Registry for Chest ProcedurEs (SCOPE)
Authors: Tremblay Alain , Chee Alex C , Dhaliwal Inderdeep , Dumoulin Elaine , Gillson Ashley , MacEachern Paul R , Mitchell Michael , Schieman Colin , Stollery Daniel , Li Pen , Fortin Marc , Tyan Chung C , Vakil Erik , Hergott Christopher 
Published: January 2021

IntroductionThe Stather Canadian Outcomes registry for chest ProcedurEs (SCOPE registry) is a Canadian multicentre registry of chest procedures.Methods and analysisThe SCOPE registry is designed as a multicentre prospective database of specific bronchoscopic or other pulmonary procedures. Each procedure of interest will be associated with a registry module, and data capture designed to evaluate effectiveness of procedures on relevant patient outcomes. Participating physicians will be asked to enter data for all procedures performed in a given module. The anonymised dataset will be housed in a web-based electronic secure database. Specific modules included will be based on participating physician suggestions, capacity and consensus of the steering committee and relevance of hypotheses/research potential.Ethics and disseminationThe central registry is under approval from the Conjoint Health Research Ethics Board at the University of Calgary. We aim for registry data to lead to publication of manuscripts in international medical journals as the primary mode of dissemination. Data may also be used by local investigators for personal and/or institutional quality control purposes as well as to inform health policies. Data requests from non-participating investigators for use under ethics approved research protocols can be considered.
Orotracheal intubation incorporating aerosol-mitigating strategies by anaesthesiologists, intensivists and emergency physicians: a simulation study
Authors: Silveira Saullo Queiroz , da Silva Leopoldo Muniz , Ho Anthony M-H , Kakuda Cláudio Muller , Santos Daniel Wagner de Castro Lima , Nersessian Rafael Souza Fava , Abib Arthur de Campos Vieira , de Sousa Marcella Pellicciotti , Mizubuti Glenio Bitencourt 
Published: January 2021

BackgroundOrotracheal intubation (OTI) can result in aerosolisation leading to an increased risk of infection for healthcare providers, a key concern during the COVID-19 pandemic.ObjectiveThis study aimed to evaluate the OTI time and success rate of two aerosol-mitigating strategies under direct laryngoscopy and videolaryngoscopy performed by anaesthesiologists, intensive care physicians and emergency physicians who were voluntarily recruited for OTI in an airway simulation model.MethodologyThe outcomes were successful OTI, degree of airway visualisation and time required for OTI. Not using a stylet during OTI reduced the success rate among non-anaesthesiologists and increased the time required for intubation, regardless of the laryngoscopy device used.ResultsSuccess rates were similar among physicians from different specialties during OTI using videolaryngoscopy with a stylet. The time required for successful OTI by intensive care and emergency physicians using videolaryngoscopy with a stylet was longer compared with anaesthesiologists using the same technique. Videolaryngoscopy increased the time required for OTI among intensive care physicians compared with direct laryngoscopy. The aerosol-mitigating strategy under direct laryngoscopy with stylet did not increase the time required for intubation, nor did it interfere with OTI success, regardless of the specialty of the performing physician.ConclusionsThe use of a stylet within the endotracheal tube, especially for non-anaesthesiologists, had an impact on OTI success rates and decreased procedural time.
Stable isotope analysis suggests that tetrodotoxin-resistant Common Gartersnakes (Thamnophis sirtalis) rarely feed on newts in the wild
Authors: Durso Andrew M. , Neuman-Lee Lorin A. , Hopkins Gareth R. , Brodie Edmund D. 
Published: January 2021

Toxin-resistant predators may suffer costs from eating chemically defended prey and do not feed exclusively on toxic prey. Common Gartersnakes (Thamnophis sirtalis (Linnaeus, 1758)) have been considered the drivers of an evolutionary arms race with highly toxic newts (genus Taricha Gray, 1850), which they consume with few or no deleterious effects. However, how frequently newts are consumed in nature is less clear. To address this question, we investigated the diets of Th. sirtalis at a site in central Oregon where snakes have high levels of resistance and newts have high levels of tetrodotoxin in the skin. Because snake diets are difficult to quantify using traditional means, we used stable isotopes to estimate the proportion of Th. sirtalis diets made up of newts. Our estimate for the proportion of Th. sirtalis diet made up of Rough-skinned Newts (Taricha granulosa (Skilton, 1849)) at this site is 3.2%. Mole Salamanders (genus Ambystoma Tschudi, 1838) were predicted to be the most important prey, followed by slugs, chorus frogs, and mice, with a very minor role for earthworms. Our results demonstrate that even though Th. sirtalis are physiologically capable of consuming toxic prey, they do not often do so. Generalist predators can be exposed to very strong selection from, and exert reciprocal selection on even rarely eaten, chemically defended prey.
Straightening of superconducting HERA dipoles for the any-light-particle-search experiment ALPS II
Authors: Albrecht Clemens , Barbanotti Serena , Hintz Heiko , Jensch Kai , Klos Ronald , Maschmann Wolfgang , Sawlanski Olaf , Stolper Matthias , Trines Dieter 
Published: January 2021

AbstractAt DESY the ALPS II experiment is being installed in the HERA tunnel to search for axion like particles. A laser beam will be injected into the magnetic field of a string of superconducting (s.c.) dipole magnets, available from the HERA proton storage ring, to produce axion like particles. After passing a light tight wall, the ALPs can reconvert into photons in a second string of HERA s.c. dipoles. The sensitivity of the experiment will be increased by two mode-matched optical cavities before and behind the wall. The dipoles for the HERA storage ring are curved, suited for stored proton beam. However, the curvature of the magnets limits the aperture and hence the performance of the optical resonators beyond a certain length. As the sensitivity of the search scales with the length of the magnetic field, the aperture for the optical resonators inside the HERA dipoles was increased by straightening the curved magnet yoke. The procedure of straightening the s.c. HERA dipoles is described in this report.
Injection of Lidocaine Alone versus Lidocaine plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation
Authors: Alizargar Javad , Etemadi Sh Milad , Kaviani Nasser , Wu Shu-Fang Vivienne , Jafarzadeh Keyvan , Ranjbarian Parisa , Hsieh Nan-Chen 
Published: January 2021

Objectives. Administration of medications such as dexmedetomidine as a topical anesthetic has been suggested in the pain control in dentistry. This double-blind randomized control trial study evaluated postoperative pain and associated factors following impacted third molar extraction surgery. Lidocaine alone was taken as the control and lidocaine plus dexmedetomidine as the intervention. Materials and Methods. Forty patients undergoing mandibular third molar extraction entered the study and were randomly allocated to the control and interventional groups. 0.15 ml of dexmedetomidine was added to each lidocaine cartridge and the drug concentration was adjusted to 15 μg for the intervention group while only lidocaine was used in the control group. A visual analog scale was used to measure and record pain levels at the end of the surgery and 6, 12, and 24 hours after the surgery and number of painkillers taken by the patients after the surgery was also recorded. Results. Pain scores of the intervention group decreased significantly during the surgery and also 6, 12, and 24 hours after the surgery compared to the control group. The pain score was correlated significantly with our intervention during the surgery and also 6 and 12 hours after that (all

P

value
<
0
.
05

). There was a nonsignificant reduction in the number of painkillers taken by the patients at 6, 12, and 24 hours after surgery (all

P
value
>
0
.
05

). Conclusion. In patients undergoing molar surgery, administration of a combination of dexmedetomidine and lidocaine is beneficial for the pain control. Clinical Relevance. Compared to the injection of lidocaine alone, combination of dexmedetomidine and lidocaine can be used for a better pain control in molar surgeries.