bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ex Vivo Liver Resection and Autotransplantation as Surgical Option for Zone II–III Leiomyosarcoma of IVC: A Case Report and Literature Review
Authors: Tuxun Tuerhongjiang , Li Tao , Apaer Shadike , He Yi-Biao , Bai Lei , Gu Shen-Sen , Wang Zhi-Peng , Huo Qiang , Wang Jiang , Zhao Jin-Ming 
Published: June 2021

We report the first documented case of leiomyosarcoma at zone II-III of inferior vena cava with thrombi in three hepatic veins undergoing ex vivo liver resection and autotransplantation (ELRA) and hepatic veins thrombectomy. A 33-year-old female patient presented with abdominal distention and lower extremities edema. Abdominal wall varicosis and shifting dullness were positive on physical examination. Her liver function was classified as Child-Pugh B and a solid tumor at retro-hepatic vena cava extending to right atrium with thrombi in three hepatic veins were confirmed. The diagnosis of leiomyosarcoma with Budd-Chiari syndrome was highly suspected with preoperative ultrasound, echocardiogram, CT scan, and three-dimensional reconstruction. A zone II-III leiomyosarcoma of IVC origin was confirmed at surgery and ex vivo liver resection and autotransplantation, and hepatic vein thrombectomy with atrial reconstruction were performed under cardiopulmonary bypass (CPB). Operative time, anhepatic time, and CPB time were 12 h, 128 min, and 84 min, respectively. The patients experienced post-operative liver dysfunction and was cured with conservative therapy. Hepatic recurrence two years after surgery was managed with radiofrequency. The patient was alive with liver metastasis three years after surgery. Despite being regarded as an extremely aggressive procedure, ELRA could be considered in the treatment of advanced leiomyosarcoma with Budd-Chiari syndrome and hepatic vein thrombi.
Clinical Outcomes of Tanezumab With Different Dosages for Patient With Osteoarthritis: Network Meta-Analysis
Authors: Hu Rui , Song Ya-Feng , Yang Zhi-Yan , Zhang Chao , Tan Bo 
Published: June 2021

Background: Osteoarthritis (OA) high disability rate will increase as people getting older, and is the most prevalent form of arthritis in the future. This study identified the clinical effects of optimum doses of tanezumab for patients with OA.Method: Three electronic databases were searched up until January 15, 2021. The mean difference (MD) or odds ratio (OR) was considered an effect measure. The design-by-treatment interaction model was adopted for network meta-analyses. Analyses were conducted using WinBUGS 1.4.3 and R 4.0.5 software.Results: nine publications with 10 studies were included. Compared with placebo in network meta-analysis, except the outcomes of Western Ontario and McMaster Universities Osteoarthritis (WOMAC) stiffness subscale and joints replaced, all dosages of tanezumab in the other effectiveness outcome were superior to placebo, and the difference was statistically significant. However, there was no statistical difference among all different doses of tanezumab. Compared with placebo, except the outcomes of adverse events (AEs) and AEs of abnormal peripheral sensation, all different dosages of tanezumab weren’t superior to placebo in the other effectiveness outcome, and the difference was statistically significant. The 10 mg of tanezumab with highest SUCRA had the best effect, but it was associated with a higher safety event. Compared with placebo, except the outcomes of WOMAC stiffness subscale and joints replaced, all dosages of tanezumab in the other effectiveness outcome were superior to placebo, and the difference was statistically significant. Compared with placebo, except for the outcomes of AEs and AEs of abnormal peripheral sensation, all dosages of tanezumab in the other effectiveness outcome were superior to placebo, and the difference was statistically significant. Other direct comparisons showed no statistical difference.Conclusion: This study recommended that clinicians should give priority to the treatment of OA patients with a low dose of 2.5 mg according to the patient’s condition and actual situation. If the effect using tanezumab with 2.5 mg is not satisfactory, the increase up to 10 mg should be carefully pondered, because of a more unbalanced risk/benefit ratio.
AGR3 Regulates Airway Epithelial Junctions in Patients with Frequent Exacerbations of COPD
Authors: Ye Rui , Wang Cuihong , Sun Pengbo , Bai Shuang , Zhao Li 
Published: June 2021

Background: The mechanisms underlying differences in the susceptibility to chronic obstructive pulmonary disease (COPD) exacerbations between patients are not well understood. Recent studies have shown that the patients with frequent COPD exacerbations is related to specific protein expression in lung tissue. Anterior gradient 3 (AGR3) is expressed in airway epithelial cells in the lung and proteomic analysis revealed that its expression is decreased in patients with frequent COPD exacerbations. Moreover, the loss of epithelial integrity might facilitate trans-epithelial permeability of pathogens in such patients. This study was performed to determine that AGR3 protein play a role in COPD frequency exacerbators.Methods: Human lung tissues were collected from current-smoking patients (Control; n = 15) as well as patients with infrequent COPD exacerbations (IFCOPD; n = 18) and frequent COPD exacerbations (FCOPD; n = 8). While AGR3 protein expression was measured by immunohistochemistry and western blotting, AGR mRNA expression was determined by real time quantitative polymerase chain reaction (RT-qPCR). Furthermore, adherent junctions (AJs) and tight junctions (TJs) protein expression in human lung tissues were measured by immunohistochemistry. The effects of cigarette smoke extract (CSE) on AJ and TJ protein and mRNA expression in BEAS-2B cells were assessed by western blotting and RT-qPCR. In addition, the effect of AGR3 overexpression and knockdown on AJ and TJ protein expression was determined.Results: AGR3 was mainly expressed in the airway epithelium and AGR3-positive products were localized in the cytoplasm. Western blotting and RT-qPCR results showed that AGR3 protein (p = 0.009) and mRNA (p = 0.04) expression in the FCOPD group was significantly lower than that in the IFCOPD group. Moreover, E-cadherin, occludin, and zonula occludens-1 (ZO-1) expression was lower in the FCOPD group than in the IFCOPD group. The protein and mRNA expression of E-cadherin, occludin, and ZO-1 was decreased within 24 h post-CSE exposure. AGR3 overexpression rescued CSE-induced downregulation of E-cadherin, occludin, and ZO-1.Conclusion: Difference in AGR3 expression in the lung tissue might be correlated with increased susceptibility to COPD exacerbation. AGR3 can prevent CSE-induced downregulation of E-cadherin, occludin, and ZO-1 in airway epithelial cells. Loss of AGR3 might promote viral and bacterial infection and induce immune inflammation to increase COPD exacerbation.
The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers
Authors: Coskun Hande , Elbahi Fatima Azzahra , Al-Karagholi Mohammad Al-Mahdi , Ghanizada Hashmat , Sheykhzade Majid , Ashina Messoud 
Published: June 2021

BackgroundCalcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (KATP) channels. Here, we investigated the effect of the KATP channel blocker glibenclamide on CGRP-induced headache and vascular changes in healthy volunteers.MethodsIn a randomized, double-blind, placebo-controlled, cross-over study, 20 healthy volunteers aged 18–27 years were randomly allocated to receive an intravenous infusion of 1.5 μg/min CGRP after oral pretreatment with glibenclamide (glibenclamide-CGRP day) or placebo (placebo-CGRP day). The primary endpoints were the difference in incidence of headache and the difference in area under the curve (AUC) for headache intensity scores (0–14 h) between glibenclamide and placebo. The secondary endpoints were the difference in AUC for middle cerebral artery blood flow velocity (VMCA), superficial temporal artery (STA) and radial artery (RA) diameter, facial flushing, heart rate (HR) and mean arterial blood pressure (MAP) (0–4 h) between glibenclamide and placebo.ResultsWe found no significant difference in the incidence of headache between glibenclamide-CGRP day (14/20, 70%) and placebo-CGRP day (19/20, 95%) (P = 0.06). The AUC for headache intensity, VMCA, STA, RA, facial skin blood flow, HR, and MAP did not differ between glibenclamide-CGRP day compared to placebo-CGRP day (P &gt; 0.05).ConclusionPretreatment with a non-selective KATP channel inhibitor glibenclamide did not attenuate CGRP-induced headache and hemodynamic changes in healthy volunteers. We suggest that CGRP-induced responses could be mediated via activation of specific isoforms of sulfonylurea receptor subunits of KATP channel.
Uma proposta de valoração do turismo de mergulho e surf nas Unidades de Conservação marinhas do Arquipélago de Fernando de Noronha (PE)
Authors: Silva-Júnior José Martins da , Souza Lume Garcia Monteiro de , Weysfield Flávia Queiroz , Martins Mariana Andrade , Silva Flávio José de Lima 
Published: June 2021

O turismo vem crescendo nas últimas décadas assim como a visitação a Unidades de Conservação (UCs). O incremento do turismo em UCs pode ajudar economicamente a região a se estruturar e investir na conservação. É fundamental realizar estudos para identificar o perfil do turista que visita as UCs, principalmente quanto à sua consciência ambiental. O ecoturismo, turismo de esportes e o de aventura têm grande potencial de serem atividades turísticas sustentáveis. Desta maneira, o presente estudo tem como objetivo realizar a valoração do turismo de surf e mergulho em Fernando de Noronha. A metodologia usada foi o método custo de viagem. Foram realizadas análises de dados pretéritos, metadados e de entrevistas com surfistas e mergulhadores visitantes no ano de 2019. Foi verificado que esse público é composto majoritariamente por adultos jovens com alto valor aquisitivo. Os gastos médios totais das viagens dos surfistas e dos mergulhadores foram R$ 7.912,47 e R$ 8.331,34, respectivamente. Os principais gastos para surfistas e mergulhadores foram com hospedagem, passagem e alimentação. Os gastos com mergulho representaram apenas 8% do total da viagem dos mergulhadores e foi o gasto com maior nível de satisfação. Já para os surfistas, o gasto que mais valeu a pena foi com o aluguel de automóvel (12% do total da viagem) para levar seus equipamentos a diversas praias. Outros gastos com alto nível de satisfação foram os relacionados ao contato com a natureza, como passeio de barco e canoa havaiana. Foi perceptível, que esse público injeta significativo capital na ilha. Desta maneira, fica claro que este público tem potencial em auxiliar na manutenção de um turismo econômico e ambientalmente sustentáveis, desde que também sejam oferecidos cursos de formação para prestadores de serviços turísticos e orientações para visitantes, para que o surf e mergulho não se tornem predatórios.
PSYCHOLOGICAL AND PEDAGOGICAL ASPECTS AND VALUE PREROGATIVES OF FAMILY LEGAL EDUCATION OF ADOLESCENTS IN MODERN RUSSIA
Authors: Туркаева Л. В. , Астамирова Х. Х. , Хадуева Я. А. 
Published: June 2021

В статье рассматриваются психолого-педагогические аспекты семьи как ячейки современного общества, выступающей фундаментальной основой социально-правовой политики государства. Ценностные прерогативы воспитания молодежи обоснованы в статье комплексом критериев повышения уровня семейно-правового воспитания малолетних подростков, совершенствования так называемого «родительского» института, пропаганды значимости образа семейной жизни. Семейное воспитание детей в настоящее время - существенный атрибут генезиса национальной политики. Особое внимание в статье уделено тематическому анализу различных экономико-социальных составляющих государства, направленных на создание благодатной почвы для роста демографических показателей, обеспечение необходимым комплексом материально-технических ресурсов семьи, находящейся в трудном социальном положении.
Today, the family as a cell of modern society, which is the fundamental basis of the state’s social and legal policy, is one of the criteria for raising the level of family values in terms of educating young adolescents, improving the so-called “parental” institution, and promoting the significance of family life. The various economic and social components of the state were aimed at creating a fertile ground for the growth of demographic indicators, providing the necessary complex of material and technical resources for families in difficult social situations. Whatever you may say, but a child brought up in a full-fledged healthy family, where he is comfortable and safe, clearly differs from other teenage children left without parental care for certain reasons.
CAMPUS OF THE GROZNY STATE OIL TECHNICAL UNIVERSITY IN THE SPACE OF THE URBAN ENVIRONMENT IN GROZNY
Authors: Алиев С. А. , Насуханов Ш. А. , Таймасханов Х. А. , Муртазаев И. С-А. 
Published: June 2021

В статье описаны основные принципы проектирования кампуса Грозненского государственного нефтяного технического университета. Представлены решения, принятые при разработке дизайна благоустройства территории кампуса университета, влияющие на формирование городской среды и город в целом. Также приведены формы участия студентов и преподавателей Грозненского нефтяного в разработке и реализации проекта, а также в национальных проектах, реализующихся на территории Чеченской Республики.
The article describes the basic design principles of the campus of the Grozny State Oil Technical University. The decisions made in the development of the design of the improvement of the campus of the university are presented, affecting the formation of the urban environment and the city as a whole. Also, the forms of participation of students and teachers of the Grozny Oil Field in the development and implementation of the project, as well as in the implementation of national projects being implemented on the territory of the Chechen Republic are given.
TEACHING AND LEARNING FOREIGN LANGUAGES USING ICT
Authors: Алисултанова Э. Д. , Исаева М. З. , Болтиев Д. У. 
Published: June 2021

В образовательном сообществе резко возросло использование информационных и коммуникационных технологий (ИКТ) в преподавании и изучении иностранных языков. Учителя получают доступ к инновациям и внедряют их, не всегда осознавая их значение для самих себя и своих учеников. В статье представлены некоторые особенности ИКТ, которые можно использовать учебной среде, а также использование видео в качестве инструмента ИКТ на уроках иностранного языка. В данной статье также обсуждается роль учителя во внедрении технологий, именно учитель, а не технология, определяет качество обучения и преподавания. Роль учителя будет поставлена под угрозу, если мы интегрируем информационно-коммуникационные технологии в образование; однако в «техно-гуманистической» системе, учитель, ученики и технологии образуют прочный и значимый союз.
The use of information and communication technologies (ICT) in teaching and learning foreign languages has increased dramatically in the educational community. Teachers gain access to innovations and implement them, not always realizing their importance for themselves and their students. The article presents some of the ICT features that can be used in a learning environment, as well as the use of video as an ICT tool in foreign language lessons. This article also discusses the role of the teacher in the implementation of technology, it is the teacher, not technology, that determines the quality of teaching and learning. The role of the teacher will be compromised if we integrate information and communication technologies into education; however, in a “techno-humanistic” system, teacher, students and technology form a strong and meaningful union.
Tuturan Ekspresif Pengajar BIPA dalam Pembelajaran Keterampilan Berbicara dengan Metode Dengar Pandang
Authors: Rudi Rudi , Mujianto Gigit 
Published: June 2021

Penelitian ini bertujuan mendeskripsikan bentuk tuturan ekspresif pengajar BIPA, dan sintaks pembelajaran dengan metode dengar pandang. Penelitian dilakukan dengan pendekatan deskriptif kualitati. Sumber data penelitian adalah interaksi pembelajaran antara pengajar dan pemelajar BIPA dalam video Pesta Akademia 21 Tahun APPBIPA: Kelas Maya APPBIPA Jawa Timur dan Sumatra Utara. Adapun data penelitian berupa kalimat yang mencerminkan tuturan ekspresif pengajar BIPA dan sintaks pembelajaran keterampilan berbicara dengan metode dengar pandang. Pengumpulan data dilakukan dengan teknik observasi. Teknik analisis data menggunakan model Miles dan Huberman, yang meliputi tahapan reduksi data, penyajian data, dan penarikan kesimpulan/verifikasi. Hasil penelitian menunjukkan: (1) bentuk tuturan ekspresif pengajar BIPA meliputi ucapan terima kasih, ucapan minta maaf, ucapan memuji, dan ucapan selamat. (2) Sintaks pembelajaran keterampilan berbicara dengan metode dengar pandang meliputi tahapan, penyajian konten oleh pengajar BIPA, pengajar BIPA menjelaskan konten, pengulangan konten, dan pemelajar BIPA mengembangkan keterampilan berbicara.Katakunci: dengar pandang, sintaks pembelajaran, tuturan ekspresif Abstract:This study aims to describe the expressive speech act of BIPA teachers and the syntax of learning using dengar pandang method. This research used descriptive qualitative approach. The source of research data was learning interaction between BIPA teachers and learners in the video Pesta Akademia 21 Tahun APPBIPA: Kelas Maya APPBIPA Jawa Timur dan Sumatra Utara. The data were sentences that show the BIPA teacher's expressive speech act and the syntax of learning speaking skills using the pandang dengar method. Data were collected by using observation technique. The data analysis technique used Miles and Huberman model, including the stage of data reduction, data presentation, and conclusion/verification. The results showed: (1) the expressive speech acts of BIPA teachers include thanking, apologizing, praising, and congratulating. (2) The syntax of learning speaking skills using pandang dengar method including stages of content presentation by BIPA teachers, content explanation, content repetition, and BIPA learners develop their speaking skillsKeywords: dengar pandang, learning syntax, expressive speech
ТЕХНОЛОГІЧНІ ЗАСАДИ ПІДГОТОВКИ МАЙБУТНІХ МАГІСТРІВ З ДОШКІЛЬНОЇ ОСВІТИ ДО ІННОВАЦІЙНОЇ ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ
Authors: Козак Людмила 
Published: June 2021

У статті обґрунтовано технологічні засади підготовки майбутніх магістрів з дошкільної освіти до інноваційної професійної діяльності. Автором подано авторське тлумачення понять «інноваційна професійна діяльність магістра з дошкільної освіти», «готовність магістра з дошкільної освіти до інноваційної професійної діяльності»; представлено розроблену технологію підготовки майбутніх магістрів з дошкільної освіти до інноваційної професійної діяльності, яка містить концептуальний, змістово-процесуальний, оцінно-результативний компоненти. Концептуальний компонент розкриває провідну ідею, мету, завдання, підходи, принципи підготовки майбутніх магістрів з дошкільної освіти до інноваційної професійної діяльності. Змістово-процесуальний компонент охоплює етапи підготовки майбутніх магістрів з дошкільної освіти до інноваційної професійної діяльності. Оцінно-результативний компонент відображає процедуру оцінювання рівня готовності майбутніх магістрів з дошкільної освіти до інноваційної професійної діяльності та результат такої підготовки. Формування готовності майбутніх магістрів до інноваційної професійної діяльності відбувається у процесі оволодіння інноваційною складовою змісту навчальних дисциплін та виробничої практики, використання технологій проблемного, евристичного, проєктного, контекстного, інтерактивного, змішаного навчання, цифрових сервісів і ресурсів, сучасних форм організації освітнього процесу в закладі вищої освіти.
Aspectos socioeconômicos relacionados à pesca amadora de robalo (Centropomus undecimalis e C. parallelus) na Baía da Babitonga, Santa Catarina, Brasil.
Authors: Menezes Antonio Alberto da Silveira , Lin Celso Fernandes , Silva Carlos , Dos Santos Roberta Aguiar 
Published: June 2021

O presente trabalho visa mostrar alguns aspectos da pesca amadora das espécies de robalo Centropomus undecimalis e Centropomus parallelus, na Baía da Babitonga, localizada no norte de Santa Catarina. Para descrição da pescaria e levantamento dos dados do perfil socioeconômico dos pescadores amadores, foram realizadas entrevistas estruturadas e semiestruturadas (Gil, 1999) e observações “in situ”. Entre setembro de 2004 e outubro de 2006, foram entrevistados 417 pescadores amadores embarcados em 23 saídas a campo. Para avaliação das capturas, foram aplicados formulários durante o 2° semestre de 2006, em duas marinas situadas em pontos diferentes da baía, sendo amostradas 860 embarcações, para 2.184 pescadores atuantes. Foram distribuídos questionários em pousadas na localidade de Palmital, em Garuva-SC, com o objetivo de se obter informações sobre a composição e características dos grupos de pescadores, sendo que apenas 62 pessoas responderam. Os resultados indicaram que o pescador amador atuou durante o ano todo na região; 96% deles foram compostos pelo sexo masculino, idade entre 30 e 60 anos; 41% possuem o Ensino Superior completo e 60% deles possuíam a Licença de Pesca Amadora. O automóvel é o principal meio de transporte que foi utilizado para chegar à região. Cada pescador utilizou uma ou duas varas com molinete ou carretilha e um único anzol por petrecho, sendo o camarão vivo a isca mais empregada. Das 30 espécies de peixes capturados, o grupo das pescadas (Cynoscion spp.) foi o segundo mais abundante, depois das duas espécies de robalo C. undecimalis e C. parallelus.
Article Sistem Informasi Pengelolaan Masjid Darussalam GKB2 berbasis Web
Authors: Purnomo Sigit , Septa Frandika 
Published: June 2021

One computer-based information system is the website, usually in its online form. The amount of activity, financial management and data processing still conducted in manual bogies of difficulty. To address that problem requires easily accessible system of management, at any time, anywhere, precisely, fast and accurate by the mosque and community. On that basis it developed a web based mosque management information systems that are made with a PHP programming language, javascript and mysql database. The goal of the system is to make it easier for the mosque to manage the financial data, to manage activities of the mosque and to make it easier for the public to search for information on the existing website system.
The sequence of these studies includes critical analysis, system desaign, implementation, testing and maintenance. The Darussalam mosque management system was tested by the black box method and focused on functional requirements using alpha testing.
This research examination is still ina purely functionality testing phase incolving unintended objects can occur without specific testing especially on the interface part where ddynamic programming of the interface elements blending in using HTML and CSS presentation of documents. So in running the system as a web-based application, it should affect the web browser in running the system.