bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Learning Method for ECG Signal Prediction Based on VMD, Cao Method, and LSTM Neural Network
Authors: Huang Fuying , Qin Tuanfa , Wang Limei , Wan Haibin 
Published: January 2021

Abstract
Background: In body area network (BAN), accurate prediction of ECG signal can not only let doctors know the patient's condition in advance, but also help to reduce the energy consumption of sensors. In order to improve the accuracy of ECG signal prediction, this paper proposes a deep learning method for ECG signal prediction. Methods: The proposed prediction method combines variational mode decomposition (VMD), Cao method and a long short-term memory (LSTM) neural network. In the method, VMD decomposes ECG data into a series of intrinsic mode functions (IMFs), which reduces the non-stationary character of ECG signals and helps to improve the prediction accuracy. Cao method is used to determine the input dimension of LSTM input layer, namely, the minimum embedding dimension of each IMF is the input dimension of LSTM input layer. Each IMF is predicted by a LSTM neural network which adopts Adam optimizer. All IMFs predictions are aggregated to get the final prediction result. Results: To evaluate the prediction accuracy of the proposed method, simulation experiments are carried out on ECG data from the MIT-BIH Arrhythmia Database. Experimental results show that the RMSE (root mean square error) and MAE (mean absolute error) of the proposed model are 0.001326 and 0.001044 respectively, which are more than 10 percent lower than the traditional prediction methods.Conclusions: Compared with some traditional prediction methods, the proposed prediction method improves the prediction accuracy obviously.
Attitudes Towards Cardiopulmonary Resuscitation Situations and the Associations of Possible Affecting Factors – a Survey Among 3,602 in-hospital Healthcare Professionals
Authors: Silverplats Jennie , STRÖMSÖE Anneli , ÄNG Björn , Källestedt Marie-Louise Södersved 
Published: January 2021

Abstract
BackgroundAttitudes among in-hospital healthcare professionals (HCPs) towards cardiopulmonary resuscitation (CPR) are poorly understood. The aim of this study was therefore to evaluate attitudes among in-hospital HCPs towards CPR and furthermore to assess the associations of possible affecting factors.MethodsA questionnaire was distributed to n=6,055 HCPs. The associations of affecting factors were analysed using binary logistic regression.ResultsThe response rate was 59% (n=3,602). Fifty three percent of HCPs felt confident in their CPR knowledge, 80% would know what to do, and 52% would be able to take command if necessary in a cardiac arrest situation. A third of HCPs were worried about making mistakes/cause complications, 57% felt stressed, and 27% felt anxious in connection to the latest real-life CPR situation. A short time since the last real-life CPR performance and a high number of previous real-life CPR performances were associated with lower odds of a worry about making mistakes/cause complications, lower odds of feeling stressed or anxious, and higher odds of feeling calm. Despite previous real-life CPR experience, there were differences in attitudes between groups of profession, and between monitored and non-monitored wards. Time since last CPR training course was associated with anxiety.ConclusionsDespite overall positive attitudes towards performing CPR, feelings of stress and anxiety were common which could reflect possible stress overload. Many HCPs work in low-risk areas of cardiac arrest, therefore regular CPR training is important to maintain competence and reduce anxiety. The possible effect of attitudes on performing CPR needs to be studied further.
A Hazardous Foreign Body Perforating the Cervical Esophagus With Extra-Esophageal Impact
Authors: Sahin Mehmet Furkan , Beyoglu Muhammet Ali , Yazicioglu Alkin , Yekeler Erdal 
Published: January 2021

Abstract
BackgroundEsophageal perforation due to foreign body is a fatal complication when not diagnosed on time and not managed properly. Although admissions to the emergency department after foreign body ingestion are frequently observed, perforating the esophagus after ingestion of sharp-edged objects and being observed in the soft tissue in the extraesophageal area is a very rare condition. MethodsThe patient, who admitted to the emergency department with dysphgia after swallowing a sharp-pointed foreign body, was retrospectively analyzed. ResultsWe present our patient who developed esophageal perforation as a result of accidentally swallowing a sharp-edged glass object which we diagnosed immediately, approached with a lateral cervical incision within 24 hours and removed from the location very close to the carotid artery in the extraesophageal area. ConclusionsPerforating esophageal foreign bodies are urgent problems that require early diagnosis and intervention. Delayed surgery can lead to fatal consequences. Trial RegistirationThis case report was retrospectively registered by Institutional Thoracic Surgery Education and Research Committe. (Number:2020-12-15/01, Date: 18/12/2020)
Efficacy of Early Antifibrotic Treatment for Idiopathic Pulmonary Fibrosis
Authors: Sugino Keishi , Ono Hirotaka , Watanabe Natsumi , Shimizu Shigeru , Ando Masahiro , Tsuboi Eiyasu , Homma Sakae , Kishi Kazuma 
Published: January 2021

Abstract
The present study aimed to clarify the efficacy of nintedanib and pirfenidone in patients with early-stage IPF. We compared survival, disease progression, and efficacy of antifibrotics between patients with IPF with Japanese Respiratory Society (JRS) disease severity system stage I with and without oxygen desaturation on the 6-minute walk test (6MWT) and increased the gender–age–physiology (GAP) staging. The severity of stage I IPF (n = 179) according to the JRS criteria consisted of the following GAP staging criteria: stage I, 111 cases; stage II, 58 cases; stage III, 10 cases. The duration from the initial visit to disease progression and survival time was significantly shorter in JRS stage I patients with oxygen desaturation on the 6MWT or with increased GAP staging (unfavorable group) compared with patients without those factors. In the unfavorable group, the forced vital capacity (FVC) decline and relative decline in percentage predicted FVC over 6 months was significantly lower in patients undergoing antifibrotic treatment compared with non-treated patients. Antifibrotics have a beneficial effect on the decline in FVC in Japanese patients with early-stage IPF who have oxygen desaturation on the 6MWT or increased GAP staging.
The Deubiquitinase OTUD3&nbsp;Stabilizes ACTN4&nbsp;to Activate NF-κB&nbsp;Signaling Pathway in Hepatocellular Carcinoma
Authors: Xie Peiyi , Chen Yanglin , Zhang Hongfei , Zhou Guichao , Chao Qing , Wang Jiangwen , Wang Zhiyuan , Hao Liang , Huang Da 
Published: January 2021

Abstract
Background: OTUD3, a deubiquitinating enzyme, has emerged as important role in some cancer. It showed that OTUD3 plays suppressive role in breast cancer whereas oncogenic role in lung cancer. However, the function and mechanism of OTUD3 in hepatocellular carcinoma (HCC) progression remain elusive. Methods: Gene and protein expression of OTUD3 in HCC tissues were determined by qRT-PCR, western blot and immunohistochemistry. A series of gain- and loss-of-function assays were used to investigated the role of OTUD3 in HCC cells progression. Moreover, mass spectroscopic analysis and RNA-seq were used to identify the downstream targets of OTUD3 in HCC cells. The interaction between OTUD3 and ACTN4 was examined through co-IP experiment and in vitro ubiquitination assay.Results: In our research, OTUD3 was significantly overexpressed in HCC tissues and higher OTUD3 expression was correlated with bigger tumor size, more distant metastasis, and worse TNM stage. Additionally, OTUD3 promoted HCC cells growth and metastasis in vitro and in vivo. Furthermore, ACTN4 was identified as a downstream target of OTUD3 and ACTN4 protein level was significantly related to OTUD3 expression. Rescue experiments indicated that ACTN4 was essential for OTUD3-mediated HCC proliferation and metastasis in vitro and in vivo. Moreover, we identified that NF-κB signaling pathway was activated by OTUD3 through ACTN4 to promote HCC cells progression. Importantly, OTUD3 protein level was correlated with ACTN4 protein level and activity of NF-κB signaling pathway in HCC tissues. Conclusion: Our findings identify the oncogenic role of OTUD3 in HCC and suggest that OTUD3 can be considered as a pivotal prognostic biomarker and a potential therapeutic target.
Co-treatment With the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer’s Disease
Authors: Liu Quan Feng , Choi Hoon , Son Taekwon , Kim Young-Mi , Kanmani Suganya , Chin Young-Won , Kim Seung-Nam , Kim Kwang-Ki , Kim Kyu-Won , Koo Byung-Soo 
Published: January 2021

Abstract
Background: Alzheimer’s disease (AD) is a lethal progressive neurodegenerative disorder. Currently, many acetylcholinesterase inhibitors, such as donepezil, is widely used for the treatment of AD. However, the efficacy of long-term donepezil use is limited. SIP3, a mixture of Santalum album, Illicium verum, and Polygala tenuifolia, a new formula derived from traditional Korean herbal medicine. In this study, SIP3 were assessed the survival of Drosophila AD model and synergistic effect of SIP3, donepezil co-treatment of AD using APP/PS1 transgenic mice. Methods: In Drosophila AD models, we analyzed the survival, climbing ability and acridine orange (AO) staining. In APP/PS1 mice, at six months of age were randomized into four groups. Then, these groups were orally administered vehicle (for the control), donepezil, low and high doses SIP3 plus Donepezil respectively for six months. The passive avoidance test (PAT) and the Morris water maze (MWM) were analyzed cognitive behavioral changes. In addition, the forced swimming test (FST) and the tail suspension test (TST) were assessed depression-like behavior. To investigate the molecular and cellular mechanisms underlying positive effects of SIP3 on AD, the cerebral cortex transcriptomes were analyzed by RNA sequencing.Results: Using the passive avoidance test (PAT), we analyzed the combination of SIP3 and donepezil improved the learning capabilities and memory of APP/PS1 mice, compared with the group treated with donepezil only, in late stage of AD. In addition, using the Morris water maze (MWM) test, co-treatment with donepezil and a low concentration of SIP3 significantly ameliorated cognitive impairment. Co-administration of SIP3 and donepezil effectively reduced depression-like behavior in the forced swimming and tail suspension tests. Furthermore, RNA sequencing of cerebral cortex transcriptome revealed that gene expression profiles after low dose of SIP3 co-treatment are slightly similar to those of normal phenotype mice than those obtained after donepezil treatment alone. Gene ontology (GO) along with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway have demonstrated that differentially expressed genes were involved in locomotor behavior and neuroactive ligand-receptor interactions. Collectively: our results suggest that co-treatment of low dose of SIP3 and donepezil improves impaired learning, memory, and depression in late stage of AD in mice.
Glial Associated Impairment of the Glymphatic System in Experimental Neonatal Hydrocephalus
Authors: Vasas Joseph Tyler , McAllister James Pat , Eskandari Ramin 
Published: January 2021

Abstract
Background

Changes in aquaporin-4 (AQP4) and glial fibrillary acid protein (GFAP) expression by astrocytes have been observed in several pathologies. It is hypothesized that prolonged exposure to pathologically elevated intracranial pressure (ICP) may be linked to impaired glymphatic pathways. In this study we explore histological consequences of prolonged pressure-induced injury in a feline model of neonatal hydrocephalus through changes in AQP4 and GFAP expression. We discuss the implications this may have in gaining a better understanding of the underlying mechanisms of hydrocephalus (HCP).
Methods

Using a neonatal feline model, obstructive HCP was induced through kaolin injection into the cisterna magna. Time between injection and intervention via ventricular reservoir placement was used to divide groups into early and late treatment groups. Early and late animals received reservoirs at 1- and 2-weeks post kaolin injection, respectively. Controls underwent sham operations (saline injection instead of kaolin). Animals were sacrificed at 4 months allowing for a chronic treated hydrocephalic model at time of brain harvest. Immunofluorescent staining for GFAP, AQP4 and DAPI was performed on histological brain sections from each group, and densitometry was used to quantify the relative signal of protein expression.
Results

Hydrocephalus was seen in all animals receiving kaolin injection as demonstrated by magnetic resonance imaging, clinical examination and neurological sequelae. Hydrocephalic animals demonstrated lower levels of perivascular AQP4 expression, increased diffuse AQP4 expression and increased glial scarring of perivascular, ependymal and subependymal spaces. Cerebral microvasculature of early treatment groups demonstrated increased astrocytic processes in the perivascular spaces, while late treatment groups demonstrated increased glial scar formation. Overall, the glymphatic system was severely disrupted in chronic treated hydrocephalus compared to controls.
Conclusions

Reactive astrogliosis and AQP4 mislocation are evident in early and late reservoir-treated HCP. Glial scarring in the perivascular, ependymal and subependymal spaces concurrent with AQP4 internalization from the perivascular region are prominent in HCP conditions present within the neonatal period. Delay in treatment by 1 week demonstrates quantifiable increases in perivascular and ependymal glial scarring at 4 months of age. Further investigation is needed to correlate glymphatic disruption with impaired CSF absorption and its role in promoting progressive hydrocephalus.
Rosiglitazone Protects Blood-Brain Barrier Integrity Following Ischemic Stroke by Reducing MMP-9 Expression Through a Caveolin-1-Dependent Pathway
Authors: Huang Qianyi , Zhong Wei , Yi Xia , Qin Zhen , Tang Xiangqi 
Published: January 2021

Abstract
Background

Rosiglitazone (RSG) is a widely used antidiabetic drug which activates peroxisome proliferator-activated receptor-γ. Recent work have shown that RSG can up-regulate caveolin-1 levels and ameliorate both chronic and acute brain injury. However, whether rosiglitazone can ameliorate ischemic injury in the brain via a caveolin-1-dependent pathway remains unknown.
Methods

Adult male sprague-dawley rats were randomly divided into sham operation group, model group, rosiglitazone group and rosiglitazone + daidzein group. The rat models of middle cerebral artery occlusion (MCAO) was established using the suture method, with ischemia for 2 hours and reperfusion for 22 hours. Neurological deficits were evaluated by the methods of Longa’s standard scoring. Cerebral infarction volume was observed by staining with 2, 3, 5-triphenyltetrazolium chloride. Evans blue content reflects BBB permeability. The expressions of caveolin-1, matrix metalloproteinase-9(MMP-9) and occludin were detected by immunofluorescent staining and western blot.
Results

In this study, we found that the expression of caveolin-1 was increased in a rat model of stroke, and treatment with RSG significantly increased the levels of caveolin-1, reduced the release of MMP-9, and increased the expression of occludin. On the other hand, a caveolin-1 inhibitor daidzein canceled the protective roles of RSG in the MCAO model.
Conclusions

These data unveil that RSG might protect blood-brain barrier integrity by down-regulating the levels of MMP-9 via a caveolin-1-dependent pathway.
Dietary Habits, BMI, and demographic characteristics affect the Academic Performance of University Students in Saudi Arabia: A cross-sectional study
Authors: Jalloun Rola A. , Shikieri Ahlam Badreldin El 
Published: January 2021

Abstract
Background

Students' academic performance remains one of the ongoing topics of debate among educators, academicians, and policy-makers. We aimed to assess the effect of dietary habits, demographic characteristics, and body mass index (BMI) on academic performance.
Method

: An epidemiological, cross-sectional, retrospective study design was conducted. Data were collected from 385 full-time, Saudi undergraduate students at Taibah University aged between 18–24 years old. Students were asked about their breakfast, fast food, and soft drink consumption, and their daily number of meals. Information about their gender, residence in hostels, and smoking status were obtained. Grade point average (GPA) was used to assess academic performance. BMI was also calculated. All statistical analyses were performed using the SPSS software program version 20.
Results

More females (n = 290; 75.3%) than males were included. High academic performers were non-smokers (P < 0.0005) and didn't stay in hostels (P = 0.026). BMI associated negatively with academic performance. Females had better academic performance (95%) compared to males (58%, P < 0.0005), GPA (2.72 vs 3.53, P < 0.0005 respectively), lower number of meals (Mean: 2.31 vs 1.99), and low prevalence of overweight/obesity (43% vs 30%).
Conclusion

Nutrition education programs targeting Taibah University students are to be developed to raise awareness about the importance of healthy eating and normal body weight.
Fabrication of perfect plasmonic absorbers for blue and near-ultraviolet lights using double-layer wire-grid structures
Authors: Motogaito Atsushi , Tanaka Ryoga , Hiramatsu Kazumasa 
Published: January 2021

Abstract
This study proposes using double-layer wire-grid structures to create narrow-band, perfect plasmonic absorbers, which depend on polarization, for the short-wavelength visible and near-ultraviolet regions of the electromagnetic spectrum. A rigorous coupled-wave analysis reveals that the maximum absorption attained using Ag and Al is ~90% at 450 nm and 375 nm. Experiments using Ag yielded results similar to those predicted by simulations. These results demonstrate that narrow-band perfect plasmonic absorbers, which depend on the polarization, can be realized at 450 nm and 375 nm using Ag or Al.
Assessment of Modern Contraceptive Utilization and Associated Factors Among Women Living With HIV/AIDS In Debre Tabor Referral Hospital In Debre Tabor Town, South Gondar Zone, North Central Ethiopia
Authors: Abebe Endeshaw Chekol , Mengie Teklie , Dejenie Tadesse Asmamaw , Muchie Zelalem Tilahun 
Published: January 2021

Abstract
Introduction: Preventing unintended pregnancy among HIV-positive women constitutes a critical global public health priority for addressing the desperate state of maternal and child health in HIV hyper endemic settings, yet few data exist on contraceptive use among women entering ART follow up in Debre Tabor Referral Hospital. Objective: The main objective of this study was to assess contraceptive utilization and associated factors among women aged 15-49 years living with HIV/AIDS in Debre Tabor Referral Hospital.Methods: Institution based cross-sectional study was conducted from January 02 to February 03, 2020 on women aged 15-49 years living with HIV/AIDS in Debre Tabor Referral Hospital. A total of 415 reproductive women living with HIV/AIDS were selected for the study using simple random sampling technique. Data was collected using a Structured questionnaires through face to face interview by two trained nurses assigned at ART clinic of DTH during data collection period. The data was presented using descriptive statistics of frequency and percentage and the association between dependent and selected independent variables was determined by inferential statistics of chi-square test.Result: The study analysis shows that there is significant association (p-value<0.05) between educational status (p-value=0.000), knowledge about modern contraceptive (p-value=0.000), spouse approval (p-value=0.000) and receive counseling about modern contraceptive (p-value=0.000) with their modern contraceptive use.Conclusion: This study in generally showed lower utilization of modern contraceptive in the study area.
Is affiliation system successful in healthcare at Turkey?
Authors: BALKAN DURSUN 
Published: January 2021

Abstract
The main objective of the study was to compare technical efficiency between affiliated and non-affiliated hospitals of Turkey. There was six otput variables and four input variables to evaluate hospitals efficiencies using with Ministry of Health (MoH) data from 2013 to 2017. Totally, 25 affiliated hospitals and 53 non-affiliated hospitals were analysed using input-oriented Data Envelopment Analysis (DEA) model under variable return to scale assumptions. The study results that, affiliated hospitals efficiency scores were higher than non-affiliated training and research hospitals. These results showed us the application of the affiliation system was successful in Turkey. Furthermore, this is the first study which has been performing whole affiliated and non-affiliated hospital efficiency measures together in Turkey and it offers an original contribution to literature with this direction.
Exercise, disability and physical functioning in older Chinese adults during their last six years of life: a cohort study
Authors: Chen Meng-Lei , Huang Cong , Huang Yu-Min , Wu Chun-Chun , Xue Sen , Yang Yu-xin , Wen Xu 
Published: January 2021

Abstract
Background

Little is known about the potential effects of exercise behaviour on disability and physical functioning (PF) in late-life. This study aimed to investigate whether exercise behaviour with four different long term exercise status influences disability and PF in older Chinese adults during their last six years of life.
Methods

Secondary data analyses were performed using participants (≥ 65 years) from the Chinese Longitudinal Healthy Longevity Study. Exercise behaviour was collected every three years during their last six years of life. 4265 participants were enrolled and divided into four groups, including long-term non-exercising (NN), non-exercising to exercise (NY), exercise to non-exercising (YN), and long-term exercising (YY). Disability was measured based on the Katz Index of Activities of Daily Living scale and divided into three disability levels. PF was included as chair-rise, pick-up book and turn-around. Risks burden in disability and PF among four groups were compared using logistic regression analyses.
Results

Compared with NN, the risk of developing severe disability was attenuated in YY (OR 0.11, 95%CI 0.06 to 0.21) and attenuated in NY (OR 0.27, 95%CI 0.17 to 0.44) and increased in YN (OR 1.36, 95%CI 1.08 to 1.72). Moderate disability risk was increased in YN (OR 1.85, 95%CI 1.26 to 2.71) only. The risk of developing physical dysfunction ( chair-rise, pick-up book, and turning around 360°) was decreased in YY and NY, and did not have significant difference in YN.
Conclusions

EP were associated with disability and PF in older Chinese adults during their late-life. Late-life exercise behaviour is still beneficial. Our findings suggest that it is meaning to encourage older people doing EP at late-life in China.