bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results from the German registry for refractory celiac disease
Authors: Weber Marko , Wolf Nina , Branchi Federica , Tangermann Paul , Itzlinger Alice , Poralla Lukas , Preiß Jan C. , Grunert Philip , Daum Severin , Siegmund Britta , Stallmach Andreas , Schumann Michael 
Published: September 2021

AbtractRefractory celiac disease (RCD) refers to a rare subgroup of patients with celiac disease who show clinical signs of malabsorption despite a gluten-free diet. RCD is divided into an autoimmune phenotype (RCD type I) and pre-lymphoma (RCD type II). To reflect the clinical reality in managing this disease in Germany, a national register was established based on a questionnaire developed specifically for this purpose. Between 2014 and 2020, a total of 53 patients were registered. The diagnosis of RCD was confirmed in 46 cases (87%). This included 27 patients (59%) with RCD type I and 19 patients (41%) with RCD type II. A wide range of diagnostic and therapeutic measures was used. Therapeutically, budesonide was used in 59% of the RCD patients regardless of the subtype. Nutritional therapy was used in only 5 patients (11%). Overall mortality was 26% (12 patients) with a clear dominance in patients with RCD type II (9 patients, 47%). In summary, RCD needs to become a focus of national guidelines to increase awareness, establish standards, and thus enable the treating physician to make the correct diagnosis in a timely manner. Moreover, we concluded that when treating such patients, contacting a specialized center is recommended to ensure sufficient management.
Akute Cholezystitis bei hohem OP-Risiko: sonografische und endoskopische Therapieoptionen
Authors: Götzberger Manuela , Nüssler Natascha , Braden Barbara , Dietrich Christoph F. , Müller Thomas 
Published: September 2021

ZusammenfassungDie Cholezystektomie ist der Goldstandard in der Behandlung der akuten Cholezystitis, hat aber bei multimorbiden Patienten oder bei schwerem Verlauf der akuten Cholezystitis ein deutlich erhöhtes OP-Risiko. In solchen Fällen kann eine Drainage der entzündeten Gallenblase in Kombination mit antibiotischer Therapie der primären Operation überlegen sein. Die Drainage kann entweder als sonografisch geführte perkutan transhepatische Gallenblasendrainage, als EUS-geführte transmurale Stentplatzierung oder endoskopisch-transpapilläre Gallenblasendrainage erfolgen. Diese minimalinvasiven Alternativen zur Cholezystektomie können sowohl als Langzeittherapie bei dauerhaft inoperablen Patienten als auch vorübergehend bei Patienten eingesetzt werden, bei denen die Cholezystektomie nach Verbesserung des Allgemeinzustands angestrebt wird.In dieser Übersicht werden die verschiedenen Drainagemethoden im Hinblick auf technische Anforderungen sowie klinische Sofort- und Langzeitergebnisse und Komplikationen diskutiert. Mit Fortschritten im Stentdesign entwickelt sich die EUS-geführte transmurale Stentplatzierung von Magen oder Duodenum in die Gallenblase zur bevorzugten Methode der Gallenblasendrainage in Zentren mit entsprechender Expertise.
Covid-19-Pandemie: Angsterleben von niedergelassenen und
Krankenhaus-Psychiatern
Authors: Bohlken Jens , Kostev Karel , Bartels Claudia , Wiltfang Jens , Broschmann Daniel , Lemke Matthias , Lempert Thomas , Michalowsky Bernhard , Riedel-Heller Steffi 
Published: September 2021

Zusammenfassung
Hintergrund Bisher gibt es keine Studien, die das Pandemie bedingte
Belastungserleben von stationär im Vergleich zu ambulant tätigen
Psychiatern untersucht hat. Es soll deshalb das Ausmaß der
Covid-19-Exposition, die Angst, das Belastungserleben und die
Bewältigungsmöglichkeiten bei niedergelassenen Psychiatern im
Vergleich zu Ärzten in psychiatrischen und psychosomatischen Kliniken
untersucht werden.
Methode Zur Erfassung von Angst- und Belastungserleben wurden
E-Mail-gestützte Fragebögen mit 13 Items genutzt. Insgesamt
wurden 105 niedergelassene Psychiater, und 73 Ärzte und Psychologen aus
vier Klinikern (inkl. Klinik für Psychosomatische Medizin und
Psychotherapie) zwischen Anfang April bis Mitte Mai 2020 befragt.
Ergebnis In ihrem Belastungserleben fühlten sich niedergelassene
im Vergleich zu Krankenhauspsychiatern häufiger stark
eingeschränkt (52,4 vs. 32,9% p=0,010),
infektionsgefährdet (35,2 vs. 13,7%, p<0,001) und
finanziell bedroht (24,7 vs. 6,9%, p=0,002). Der Anteil gut
Informierter niedergelassener Psychiater war geringer (47,6 vs. 63,0%,
p=0,043) und der Anteil mit fehlender Schutzausrüstung
höher (27,6 vs. 4,1%, p<0,001). Bei gleichem COVID-19
Expositionsniveau (8,6 vs. 8,2%) berichteten niedergelassene Psychiater
im Vergleich zu Krankenhaus-Psychiatern häufiger, wenn auch nicht
signifikant, große Angst (18,1 vs. 9,6%, p=0,114).
Risikofaktoren für ein Angsterleben waren in beiden Gruppen das
Gefühl der Einschränkung (OR=5,52, p=0,025) und
die erlebte Infektionsgefahr (OR=5,74, p=0,005). Keinen Einfluss
hatten das Expositionsniveau, die Klinik- bzw. Praxiszugehörigkeit, das
Alter, das Geschlecht und andere Dimensionen des Bedrohungserlebens und des
Bewältigungsverhaltens.
Diskussion Niedergelassene Psychiater fühlten sich im Vergleich zu
den Kollegen im Krankenhaus durch die COVID-19 Pandemie mehr belastet und
bedroht. Das Erleben von Angst war abhängig vom Gefühl der
Einschränkung und der Expositionsgefahr, nicht jedoch von der
Exposition, der Ausstattung mit Schutzmitteln. Für die
Ausprägung der Angst scheinen weniger objektive Indikatoren als das
subjektive Erleben eine wichtige Rolle zu spielen.
Suicidal Ideation and Pesticide Exposure in Rural Communities of Central India
Authors: Behere Prakash B. , Nagdive Amit B. , Behere Aniruddh P. , Yadav Richa , Fernandes Rouchelle 
Published: September 2021

AbstractBackground This study aims to evaluate association between suicidal ideation and pesticide exposure in rural communities of Wardha district of Central rural India compared with villagers who are not exposed to it.Method It was a cross-sectional study done in rural community of Wardha district in Central India. About 100 farmers who were exposed to pesticides and 100 controls who were not exposed to pesticides were included. A Semistructured proforma to record sociodemographic variables and Indian version of the Self Reporting Questionnaire-20 was used.Results Of these 200 subjects, data were available for 85 farmers in study group and 74 in control group. In the farmers group, 31% of farmers had suicidal ideas, while 8% of controls felt like ending their life.Conclusion Measures must be taken to store pesticides at a safer place thus reducing long-term exposure. Organic farming is a better choice to avoid suicidal ideas.
The Large Focal Isolated Chondral Lesion
Authors: Chahla Jorge , Williams Brady T. , Yanke Adam B. , Farr Jack 
Published: September 2021

AbstractFocal chondral defects (FCDs) of the knee can be a debilitating condition that can clinically translate into pain and dysfunction in young patients with high activity demands. Both the understanding of the etiology of FCDs and the surgical management of these chondral defects has exponentially grown in recent years. This is reflected by the number of surgical procedures performed for FCDs, which is now approximately 200,000 annually. This fact is also apparent in the wide variety of available surgical approaches to FCDs. Although simple arthroscopic debridement or microfracture are usually the first line of treatment for smaller lesions, chondral lesions that involve a larger area or depth require restorative procedures such as osteochondral allograft transplantation or other cell-based techniques. Given the prevalence of FCDs and the increased attention on treating these lesions, a comprehensive understanding of management from diagnosis to rehabilitation is imperative for the treating surgeon. This narrative review aims to describe current concepts in the treatment of large FCDs through providing an algorithmic approach to selecting interventions to address these lesions as well as the reported outcomes in the literature.
Zonal Fixation in Revision TKA: The Key Is Metaphyseal Fixation
Authors: Oh Jason H. , Scuderi Giles R. 
Published: September 2021

AbstractAs the volume of primary total knee arthroplasties continues to rise, so will the volume of revision arthroplasties. Bone loss is commonly encountered in revision surgery and must be managed appropriately to optimize outcomes. The concept of zonal fixation highlights the importance of attaining secure fixation within each of the three major osseous zones: the epiphysis, the metaphysis, and the diaphysis. While each zone is important, the metaphysis carries particular significance. The development of new implants such as metaphyseal cones and sleeves has greatly expanded the orthopedic surgeon's armamentarium to allow for solid metaphyseal fixation in virtually every case.
Surgical Treatment for Avulsion Fractures of the Anterolateral Ligament Associated with Periarticular Fractures of the Knee
Authors: Wei Xuelei , Wang Zengliang , Lu Yandong , Sun Jie , Riehl John 
Published: September 2021

AbstractThe existence and anatomy of the anterolateral ligament (ALL) of the knee are a somewhat controversial topic in orthopaedic surgery. The fixation of the avulsion fracture of the ALL (Segond fracture), associated with periarticular knee fractures, is rarely given much consideration while the major fracture fragments are reconstructed. This study aims to confirm the existence of ALL and evaluate the clinical outcomes of surgical management for avulsion fractures, involving its insertion, when associated with periarticular knee fractures. Twenty-three patients (16 males and 7 females) with avulsion fractures of the ALL associated with periarticular knee fractures were fixed with a spider plate, cannulated screw, or suture anchor. Eight patients were diagnosed with distal femoral fracture, 10 with tibial plateau fracture, and 5 with tibial eminence avulsion fracture. All patients underwent X-rays at follow-up. Clinical and functional outcomes were assessed with the pivot-shift test, objective and subjective International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner activity scale. The ALL was found and identified as a distinct ligamentous structure in all patients. Prior to Segond repair, patients had significantly more instability, as determined by pivot-shift test, than seen postoperatively (p < 0.0001). At final follow-up, the mean subjective IKDC score was 83.2 ± 10.3. Fourteen patients were graded A, 6 were graded B, and 3 was graded C on the IKDC objective score. The mean Lysholm score was 85.4 ± 12.2. The mean Tegner score was 7.5 ± 1.2. This study confirmed that the ALL is a distinct structure in the anterolateral portion of the knee. The fixation of the avulsion fracture of the ALL associated with periarticular knee fractures can be an effective procedure without specific complications. Long-term and comparative follow-up studies are necessary to confirm the effects.
Multisystem Inflammatory Syndrome in Children: Experience from October 2020 to January 2021 at a Tertiary Hospital in Navi Mumbai, India
Authors: Amonkar Priyanka S. , Kharche Suhas N. , Madave Amol A. , Gavhane Jeetendra B. 
Published: September 2021

AbstractAlthough presentation of multisystem inflammatory syndrome (MIS-C) in children is typically with fever and symptoms like diarrhea, vomiting, rash, conjunctival injection, or shock, the spectrum of associated multisystem involvement is wide. Here, we present an account of patients with MIS-C that presented at a tertiary hospital in Navi Mumbai, India in the latter half of the pandemic from October 2020 to January 2021. We retrospectively studied the clinical features of 12 patients satisfying World Health Organization criteria for MIS-C. Eleven (91.6%) required PICU admission. Median age was 7 years and two had comorbidity. At the time of presentation, eight (66.6%) had respiratory failure, four (33.3%) had shock, and one (8.3%) had renal failure. The most common system involved was respiratory (75%) followed by mucocutaneous manifestations (66.6%). Seven patients (58.3%) showed involvement of >4 systems. Atypical presentations included a 14-year-old male with COVID-19 like pulmonary involvement on computed tomography, and a 20-month-old male with gross hematuria, nephrotic range proteinuria, and rapidly progressive renal failure. Elevated N-terminal-pro B-type natriuretic peptide was seen in 75% patients and abnormal two-dimensional echo in 50%. All patients were treated with intravenous methylprednisolone at 30 mg/kg/day for 5 days. Death occurred in three (25%), all of whom had hypotensive shock at presentation. In the wake of an ongoing pandemic, any febrile child with nonspecific symptoms suggestive of multisystem involvement warrants suspicion of MIS-C and should be evaluated with the help of markers of systemic inflammation and organ involvement, after ruling out other obvious causes. We report good response to methylprednisolone in patients without hypotensive shock at presentation and its use as firstline drug may be considered in settings with financial constraints.
Augmented Reality for Retrosigmoid Craniotomy Planning
Authors: Leuze Christoph , Neves Caio A. , Gomez Alejandro M. , Navab Nassir , Blevins Nikolas , Vaisbuch Yona , McNab Jennifer A. 
Published: September 2021

AbstractWhile medical imaging data have traditionally been viewed on two-dimensional (2D) displays, augmented reality (AR) allows physicians to project the medical imaging data on patient's bodies to locate important anatomy. We present a surgical AR application to plan the retrosigmoid craniotomy, a standard approach to access the posterior fossa and the internal auditory canal. As a simple and accurate alternative to surface landmarks and conventional surgical navigation systems, our AR application augments the surgeon's vision to guide the optimal location of cortical bone removal. In this work, two surgeons performed a retrosigmoid approach 14 times on eight cadaver heads. In each case, the surgeon manually aligned a computed tomography (CT)-derived virtual rendering of the sigmoid sinus on the real cadaveric heads using a see-through AR display, allowing the surgeon to plan and perform the craniotomy accordingly. Postprocedure CT scans were acquired to assess the accuracy of the retrosigmoid craniotomies with respect to their intended location relative to the dural sinuses. The two surgeons had a mean margin of davg = 0.6 ± 4.7 mm and davg = 3.7 ± 2.3 mm between the osteotomy border and the dural sinuses over all their cases, respectively, and only positive margins for 12 of the 14 cases. The intended surgical approach to the internal auditory canal was successfully achieved in all cases using the proposed method, and the relatively small and consistent margins suggest that our system has the potential to be a valuable tool to facilitate planning a variety of similar skull-base procedures.
Treatment and Prognosis of Inflammatory Pseudotumor of the Skull Base
Authors: Perkins Sidney J. , Gao Rebecca , Glazer Tiffany A. , Zhao Cher X. , Basura Gregory , McKean Erin L. 
Published: September 2021

Abstract
Background Inflammatory pseudotumor (IPT) of the skull base is a rare, locally destructive lesion managed with a variety of treatments. We explore the impact of treatment on outcome and assess the prognosis of IPT.
Methods This is a retrospective review of IPT of the skull base at a tertiary academic medical center. The primary outcome was radiographic progression after treatment. Outcome versus tumor location was also examined and a prognostic model was developed using a logistic regression.
Results The demographics of 21 patients with IPT are reported. Treatment consisted of corticosteroids (in 80.1% of patients), disease modifying antirheumatic drugs (DMARDs; 33.3%), surgical resection (28.6%), radiation (23.8%), antibiotics (14.3%), chemotherapy (rituximab; 9.5%), and antivirals (4.8%). At 50.7 months, 50.8% had radiographic progression. Local therapy trended toward having a better response than systemic therapy (p = 0.60). IPT of the orbit required 2.4 treatment modalities, compared with 2.0 for pharyngeal IPT, and 1.3 for posterior skull base masses (p = 0.14). A total of 75% orbital IPT underwent radiographic progression, compared with 71% of pharyngeal IPT and 50% of posterior skull base masses (p = 0.62). Sixteen patients were used to create the logistic model of radiographic progression. The Cox–Snell R
2 was 0.71 (p = 0.03). No individual variables were statistically significant.
Conclusion To our knowledge, this is among the largest sample of cases describing the presentation, treatment, and prognosis of IPT of the skull base. Our data suggest that there may be an improved response with local therapy over systemic therapy and better prognosis among posterolateral skull base masses.
Pain Sensation: Infrequent Case of Root Resorption of the Lower Second Molar Root with Bone Regeneration after Impacted Third Molar Removal
Authors: Pandey Chandrashekhar , Bhattarai Bishwa Prakash , Khanijou Manop , Songkla Pimolmas Na , Wongsirichat Natthamet , Suphangul Suphachai 
Published: September 2021

AbstractThere have been infrequent case reports of bilateral root resorption in the lower second molar secondary from impacted third molar removal with bone regeneration without pain. Root resorption is commonly observed during third molar surgical impaction that affects mandibular second molars. The bone regeneration into the adjacent affected tooth is evident simply after the surgical extraction of the impacted tooth. However, there have been a few previous reports on the prognosis of the remaining resorbed tooth. Most dentists often choose to extract them when damaged if root resorption is observed. This report case involved bilateral root resorption of the lower second molar due to lower adjacent impacted third molar teeth and bone regeneration without pain sensation. After surgical extraction of bilateral lower impacted third molar teeth, the remaining teeth retained vital pulp and survived as functional teeth.
Qābeli nadāre (It is not worthy of you)
Authors: Yaqubi Mojde , Abdul Rahman Wan Rose Eliza 
Published: September 2021

Abstract
This article reports on a study of English subtitles of Persian Ostensible Offer of Money (POOM). The first stage of
this study involved identifying instances of POOM in Iranian films on the basis of their locutions (forms) and culture-specific
contextual features and underlying concepts. At this stage we highlighted the potential problems that may be encountered when
relaying the meaning of POOMs in English, and described the translation strategies used by the subtitlers. In order to corroborate
our findings, we also conducted a survey of the perceptions of non-Iranian viewers. On the basis of our analysis, we conclude
that, owing to subtitling restrictions such as space and time, subtitlers can rely on information provided in the preceding and
following scenes of instances of POOM as well as dialogues, audiences’ familiarity with Persian culture, and similarities with
other cultures in order to avoid mistranslations or misunderstandings.
Differences in execution and perception of training sessions as experienced by (semi‐) professional cyclists and their coach
Authors: Voet Jens G. , Lamberts Robert P. , de Koning Jos J. , de Jong Jelle , Foster Carl , van Erp Teun 
Published: September 2021

ABSTRACTThis study aimed to investigate whether (semi‐)professional cyclists’ execution of a training programme differs from the coach's designed training programme. Also, the study sought to ascertain, in instances where the training sessions were indeed executed as designed by the coach, whether the perception of the cyclists differed from the intention of the coach. This study highlights the differences between the coach and the individual cyclist. In total, 747 training sessions were collected from 11 (semi‐)professional cyclists. Rating of Perceived Exertion (RPE) and session Rating of Perceived Exertion (sRPE) were compared with intended RPE (iRPE) and intended sRPE (isRPE), planned by the coach. Pearson's correlation, regression coefficients and Typical Error of Estimate (TEE) were used to identify differences between the executed and planned training sessions. Moderate to large TEEs were noted between executed and intended sRPE, which indicates that cyclists do not always execute the training programme planned by the coach. Furthermore, when the training was executed as planned by the coach, very large correlations but moderate to very large TEEs were noted between cyclists’ (s)RPE and the coach's i(s)RPE, with unique individual regression coefficients. This indicates that the relationship between RPE and iRPE is unique to each cyclist. Both the different execution and perception of the training programme by the individual cyclists could cause an impaired training adaptation. Therefore, the coach must pay attention to the perception of training sessions by the individual cyclist. Improved individual management of training load could result in the optimisation of the proposed training programme.
Investigation of infinitely rapidly oscillating distributions
Authors: Kim U-Rae , Cho Sungwoong , Han Wooyong , Lee Jungil 
Published: September 2021

Abstract
We rigorously investigate the rapidly oscillating contributions in the sinc-function representation of the Dirac delta function and the Fourier transform of the Coulomb potential. Beginning with a derivation of the standard integral representation of the Heaviside step function, we examine the representation of the Dirac delta function that contains a rapidly oscillating sinc function. By contour integration, we prove that the representation satisfies the properties of the Dirac delta function, although it is a function divergent at nonzero points. This is a good pedagogical example demonstrating the difference between a function and a distribution. In most textbooks, the rapidly oscillating contribution in the Fourier transform of the Coulomb potential into the momentum space has been ignored by regulating the oscillatory divergence with the screened potential of Wentzel. By performing the inverse Fourier transform of the contribution rigorously, we demonstrate that the contribution is a well-defined distribution that is indeed zero, even if it is an ill-defined function. Proofs are extended to exhibit that the Riemann–Lebesgue lemma can hold for a sinc function, which is not absolutely integrable.
Elastic and magnetoelastic properties of TbMnO3 single crystal by nanosecond time resolved acoustics and first-principles calculations
Authors: Hemme P , Li C-H , Djemia P , Rovillain P , Houver S , Gallais Y , Sacuto A , Sakata H , Nowak S , Baptiste B , Charron E , Perrin B , Belliard L , Cazayous M 
Published: September 2021

Abstract
Time resolved pump and probe acoustics and first-principles calculations were employed to assess elastic properties of the TbMnO3 perovskite manganite having orthorhombic symmetry. Measuring sound velocities of bulk longitudinal and shear acoustic waves propagating along at least two different directions in the high symmetry planes (100), (010) and (001), provided a powerful mean to selectively determine the six diagonal elastic constants C
11 = 227 GPa, C
22 = 349 GPa, C
33 = 274 GPa, C
44 = 71 GPa, C
55 = 57 GPa, C
66 = 62 GPa. Among the three remaining off-diagonal ones, C
23 = 103 GPa was determined with a bissectrice direction. Density functional theory calculations with colinear spin-polarized provided complementary insights on their optical, elastic and magnetoelastic properties.