bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worries and Benefit Finding in Cancer Survivors and Parents: A Longitudinal Study
Authors: Prikken Sofie , Raymaekers Koen , Lemiere Jurgen , Vercruysse Trui , Uyttebroeck Anne , Luyckx Koen 
Published: December 2021

Abstract

Objective
The interplay and longitudinal associations between positive and negative illness-related experiences in childhood cancer survivors and their families remain unclear. Therefore, benefit finding, cancer-related worries, depressive symptoms, and life satisfaction were prospectively investigated in childhood cancer survivors and parents. Directionality of effects and interactions between benefit finding and cancer-related worries in predicting general well-being were examined.

Methods
Childhood cancer survivors (n = 125 at T1; aged 14–25), mothers (n = 133 at T1), and fathers (n = 91 at T1) completed two annual questionnaires on benefit finding, cancer-related worries, depressive symptoms, and life satisfaction. Cross-lagged panel analyses including benefit finding, cancer-related worries, their interaction, and depressive symptoms or life satisfaction were conducted in survivors, mothers, and fathers.

Results
Relatively high stability coefficients were found for all study variables. In survivors, cancer-related worries predicted relative increases in depressive symptoms and benefit finding over time. Benefit finding predicted relative increases in life satisfaction over time and buffered negative effects of cancer-related worries on life satisfaction. In mothers and fathers, positive correlated change at T2 (the correlation between residuals at T2) indicated that relative change in benefit finding over time was positively related to relative change in cancer-related worries.

Conclusion
Benefit finding was related both to positive well-being and negative illness experiences, which calls for more research to unravel the different functions of benefit finding over time. Clinicians should be encouraged to attend to positive illness experiences along with more negative ones to obtain a more nuanced view on the illness experiences of survivors and their families.
Complexity of finite-variable fragments of products with non-transitive modal logics
Authors: Rybakov Mikhail , Shkatov Dmitry 
Published: December 2021

AbstractWe show that products of propositional modal logics where at least one factor is one of the monomodal logics $\textbf {K}$, $\textbf {KT}$, $\textbf {KB}$ and $\textbf {KTB}$ are polynomial-time embeddable into their single-variable fragments. Consequently, we obtain results about the computational complexity of single-variable fragments of logics belonging to intervals bounded by such products. We generalize our embeddability results to expanding relativized products and to products with polymodal logics.
Upper Gastrointestinal Manifestations of Crohn’s Disease: Differential Diagnosis and Treatment of an Uncommon Presentation of Crohn’s Disease
Authors: Mehta Ketan , Kurtz Maria T 
Published: December 2021

ABSTRACT
Esophagogastroduodenoileal involvement of Crohn’s disease (CD) is uncommon; less than 5% of adult patients will suffer from this condition, although this diagnosis is likely underestimated given the lack of routine evaluation of the upper gastrointestinal tract in the absence of symptoms. An interesting differential, including sarcoidosis, eosinophilic gastroenteritis, tuberculosis, and Brunner’s gland hyperplasia, should be considered. The consequences of this diagnosis can have profound impacts on the military career of a soldier. Learning objectives of this case report include workup, differential, diagnosis, and treatment of esophagogastroduodenoileal involvement of CD, as well as discussing the psychological effects of this diagnosis and impact on an individual’s military career.
Relativistic hydrodynamical simulations of the effects of the stellar wind and the orbit on high-mass microquasar jets
Authors: Barkov Maxim V , Bosch-Ramon V 
Published: December 2021

ABSTRACT
High-mass microquasar jets, produced in an accreting compact object in orbit around a massive star, must cross a region filled with stellar wind. The combined effects of the wind and orbital motion can strongly affect the jet properties on binary scales and beyond. The study of such effects can shed light on how high-mass microquasar jets propagate and terminate in the interstellar medium. We study for the first time, using relativistic hydrodynamical simulations, the combined impact of the stellar wind and orbital motion on the properties of high-mass microquasar jets on binary scales and beyond. We have performed 3-dimensional relativistic hydrodynamic simulations, using the PLUTO code, of a microquasar scenario in which a strong weakly relativistic wind from a star interacts with a relativistic jet under the effect of the binary orbital motion. The parameters of the orbit are chosen such that the results can provide insight on the jet-wind interaction in compact systems like for instance Cyg X-1 or Cyg X-3. The wind and jet momentum rates are set to values that may be realistic for these sources and lead to moderate jet bending, which together with the close orbit and jet instabilities could trigger significant jet precession and disruption. For high-mass microquasars with orbit size a ∼ 0.1 AU, and (relativistic) jet power $L_j\sim 10^{37}(\dot{M}_w/10^{-6}\, {\rm M}_\odot \, {\rm yr}^{-1})$ erg s−1, where $\dot{M}_w$ is the stellar wind mass rate, the combined effects of the stellar wind and orbital motion can induce relativistic jet disruption on scales ∼1 AU.
A comprehensive search for the radio counterpart of GW190814 with the Australian Square Kilometre Array Pathfinder
Authors: Dobie D , Stewart A , Hotokezaka K , Murphy Tara , Kaplan D L , Buckley D A H , Cooke J , Ho A Y Q , Lenc E , Leung J K , Gromadzki M , O’Brien A , Pintaldi S , Pritchard J , Wang Y , Wang Z 
Published: December 2021

ABSTRACT
We present results from a search for the radio counterpart to the possible neutron star–black hole merger GW190814 with the Australian Square Kilometre Array Pathfinder. We have carried out 10 epochs of observation spanning 2–655 d post-merger at a frequency of 944 MHz. Each observation covered 30 deg2, corresponding to 87 per cent of the posterior distribution of the merger’s sky location. We conducted an untargeted search for radio transients in the field, as well as a targeted search for transients associated with known galaxies. We find one radio transient, ASKAP J005022.3−230349, but conclude that it is unlikely to be associated with the merger. We use our observations to place constraints on the inclination angle of the merger and the density of the surrounding environment by comparing our non-detection to model predictions for radio emission from compact binary coalescences. This survey is also the most comprehensive widefield search (in terms of sensitivity and both areal and temporal coverage) for radio transients to-date and we calculate the radio transient surface density at 944 MHz.
Stellar mass segregation as separating classifier between globular clusters and ultrafaint dwarf galaxies
Authors: Baumgardt H , Faller J , Meinhold N , McGovern-Greco C , Hilker M 
Published: December 2021

ABSTRACT
We have determined the amount of stellar mass segregation in over 50 globular clusters and ultrafaint dwarf galaxy candidates based on deep HST- and ground-based photometry. We find that the amount of mass segregation in globular clusters is strongly correlated with their relaxation time and that all clusters with relaxation times of the order of their ages or longer have little to no mass segregation. For each cluster, the amount of mass segregation seen is fully compatible with the amount expected by dynamical evolution from initially unsegregated clusters, showing that globular clusters formed without primordial mass segregation among their low-mass stars. Ultrafaint dwarf galaxy candidates split into two groups, star clusters which follow the same trend between relaxation time and amount of mass segregation as globular clusters and dark-matter dominated dwarf galaxies that are unsegregated despite having relaxation times smaller than a Hubble time. Stellar abundance and velocity dispersion data, where available, confirm our classification. After classification of the ultrafaint dwarf galaxy candidates, we find that outer halo star clusters have average densities inside their half-light radii of 0.03 ≲ ρh ≲ 1 M⊙ pc–3, while dwarf galaxies have stellar densities of 0.001 ≲ ρh ≲ 0.03 M⊙ pc–3. The reason for this separation in density is most likely a combination of the initial conditions by which the systems formed and the requirement to withstand external tidal forces.
Do gas-poor galaxy clusters have different galaxy populations? The positive covariance of hot and cold baryons
Authors: Puddu Emanuella , Andreon Stefano 
Published: December 2021

ABSTRACT
Galaxy clusters show a variety of intracluster medium properties at a fixed mass in gas fractions, X-ray luminosity and X-ray surface brightness. In this work, we investigate whether the yet-undetermined cause that produces clusters of X-ray low surface brightness also affects galaxy properties, such as richness, richness concentration, width and location of the red sequence, colour, luminosity, and dominance of the brightest cluster galaxy. We use Sloan Digital Sky Survey Data Release 12 photometry, and our analysis factors out the mass dependency to derive trends at fixed cluster mass. Clusters of low surface brightness for their mass have cluster richness in spite of their group-like luminosity. Gas-poor, low X-ray surface brightness, X-ray faint clusters for their mass display 25 per cent lower richness for their mass at the 4.4σ level. Therefore, richness and quantities depending on gas, such as gas fraction, Mgas and X-ray surface brightness, are covariant at fixed halo mass. In particular, we do not confirm the suggestion of anticorrelation of hot and cold baryons at fixed mass put forth in the literature. All the remaining optical properties show no covariance at fixed mass, within the sensitivities allowed by our data and sample size. We conclude that X-ray and optical properties are disjointed; the optical properties do not show signatures of those processes involving gas content, apart from the richness–mass scaling relation. The covariance between X-ray surface brightness and richness is useful for an effective X-ray follow-up of low-surface-brightness clusters because it allows us to pre-select clusters using optical data of survey quality and avoids expensive X-ray observations.
Spatially constrained direction-dependent calibration
Authors: Yatawatta Sarod 
Published: December 2021

ABSTRACT
Direction-dependent calibration of widefield radio interferometers estimates the systematic errors, along with multiple directions in the sky. This is necessary because with most systematic errors, which are caused by effects such as the ionosphere or the receiver beam shape, there is a significant spatial variation. Fortunately, there is some deterministic behaviour of these variations in most situations. We enforce this underlying smooth spatial behaviour of systematic errors as an additional constraint on to spectrally constrained direction-dependent calibration. Using both analysis and simulations, we show that this additional spatial constraint improves the performance of multifrequency direction-dependent calibration.
The prevalence, burden of disease, and healthcare utilization of patients with eosinophilic granulomatosis with polyangiitis in Japan: a retrospective, descriptive cohort claims database study
Authors: Sada Ken-ei , Kojo Yoshiki , Fairburn-Beech Jolyon , Sato Keiko , Akiyama Shoko , Van Dyke Melissa K , Mukai Isao 
Published: December 2021

ABSTRACT

Objectives
To estimate eosinophilic granulomatosis with polyangiitis (EGPA) prevalence and disease burden in patients with newly diagnosed EGPA in Japan.

Methods
This retrospective descriptive cohort study (GSK ID: 209751, HO-18-19652) used administrative claim data from patients (aged ≤74 years) with EGPA (study period: January 1, 2005–December 31, 2017), identified from their first ICD-10 code for EGPA (index). Data were examined during the 12 months before (baseline) and 12 months following the index date (follow-up). EGPA prevalence, respiratory comorbidities, all-cause healthcare utilization, and oral corticosteroid (OCS) use were assessed.

Results
EGPA prevalence (95%CI) increased from 4.2 (0,23.7)/million people (2005) to 38.0 (31.8,45.1)/million people (2017), was generally more common in females versus males, and increased with age. Of the 45 patients with newly diagnosed EGPA, 57.8% had acute bronchitis and 42.2% had upper respiratory tract infections during baseline. During follow-up, 60.0% of patients were hospitalized at least once and 77.8% used OCS (OCS dependent [≥80% of days]: 73.1%).

Conclusions
In Japan, EGPA prevalence increased over time, was generally more common in females, and increased with patient age. EGPA burden was high; respiratory comorbidities were common, and most patients required hospitalization and OCS use. Our data suggest additional EGPA treatment options are needed.
Effectiveness and safety of infliximab dose escalation in patients with refractory Takayasu arteritis: A real-life experience from a monocentric cohort
Authors: Tomelleri Alessandro , Campochiaro Corrado , Sartorelli Silvia , Baldassi Francesco , Fallanca Federico , Picchio Maria , Baldissera Elena , Dagna Lorenzo 
Published: December 2021

ABSTRACTObjectivesTo evaluate effectiveness and safety of infliximab dose escalation in Takayasu arteritis (TAK) patients. To identify factors associated with refractoriness to standard-dose infliximab.MethodsMedical records of infliximab-treated TAK patients from a large single-centre observational cohort were reviewed. Infliximab therapy duration, concomitant therapies, and reasons for dose escalation and therapy suspension were evaluated. Occurrence of adverse events was recorded. A comparison between patients who maintained infliximab standard-dose and those who needed dose-escalation was performed. Factors associated with refractoriness to standard dose were analysed.ResultsForty-one patients were included. Starting infliximab dose was 5 mg/kg 6-weekly and 28 patients (68%) needed dose escalation. Persistence/recurrence of clinical symptoms was the most frequent reason for escalation. Median therapy duration was 39 (IQR, 26–61) months in the standard-dose group and 68 (38–87) months in the intensified-dose group. In the intensified-dose-group, infliximab was suspended in eight patients (29%) after a median of 38 (31–71) months, due to loss of response (n = 7) or patient’s request (n = 1). Patients in the intensified-dose group had a higher number of relapses (3.4 vs 0.8 events/patient) and received a higher cumulative steroid dose (1.7 [1.6–2.3] vs 1.3 [1–1.6] g/month of prednisone). Three patients from the intensified-dose group had serious infections; one patient from the standard-dose group developed paradoxical psoriasis. At univariate analysis, age at diagnosis and age at infliximab start were associated with infliximab escalation.ConclusionIn TAK, dose escalation is safe and allows to optimise infliximab durability in refractory patients. Younger patients seem to be more refractory to standard dosages.
Proximal heat stress up-regulates angiopoietin-1 in fingers and reduces the severity of Raynaud’s phenomenon in systemic sclerosis: a single-centre pilot study
Authors: Shima Yoshihito , Watanabe Akane , Inoue Nobuto , Maruyama Tetsuya , Kunitomo Eiji , Hamano Kunihiko , Kawanishi Takashi , Takasugi Masashi , Kumanogoh Atsushi 
Published: December 2021

ABSTRACTObjectivesRaynaud’s phenomenon (RP) is a peripheral vascular disorder that frequently occurs in systemic sclerosis (SSc). Although therapeutic heating seems reasonable given that RP is elicited by cold stimuli, the effects of heating are still unclear. We examined the effects of heating applied on various body parts in SSc patients with RP of fingers.MethodsFourteen SSc patients heated their neck, elbows, and wrists with disposable heating pads for 1 week each. The visual analogue scale (VAS) for RP during each heating period was compared with that of each 1-week pre-treatment interval. On the day after the expiration of each heating period, their finger temperature, the finger blood flow, and angiogenesis-related factors (vascular endothelial growth factor, endostatin, angiopoietin-1, and angiopoietin-2) obtained from the cubital vein and fingertip were measured.ResultsThe mean VAS was significantly reduced during the heating of the neck and elbows. Fingertip blood samples showed significantly increased angiopoietin-1 after each of the heating periods and increased endostatin after wrist heating. After the termination of heating, changes in finger temperature or blood flow could not be detected.ConclusionsHeating the neck or elbows can alleviate RP in SSc. The heat up-regulates angiopoietin-1 in the fingers.
Effects of the COVID-19 pandemic on body composition among patients with rheumatoid arthritis
Authors: Mochizuki Takeshi , Yano Koichiro , Ikari Katsunori , Okazaki Ken 
Published: December 2021

ABSTRACT

Objectives
To evaluate effects of the COVID-19 pandemic on body composition among patients with rheumatoid arthritis (RA).

Methods
A total 102 patients with RA were enrolled. We examined muscle mass, fat-free mass index (FFMI) and fat mass index (FMI) values using bioelectrical impedance analysis between November 2019 and January 2020 (for the first measurement) and September 2020 and January 2021 (for the second measurement).

Results
The muscle mass was significantly decreased from a median of 34.6 kg at the first measurement to a median of 33.9 kg at the second measurement (p = 0.002). The FFMI was significantly decreased from a median of 15.3 at the first measurement to a median of 14.8 at the second measurement (p = 0.011).

Conclusions
The present study reveals that muscle mass and FFMI decreased among patients with RA during the COVID-19 pandemic.
Clinical characteristics of patients with polyarteritis nodosa based on a nationwide database in Japan
Authors: Kawazoe Mai , Nanki Toshihiro , Hagino Noboru , Ikegaya Noriko , Ito Satoshi , Kodera Masanari , Nakano Naoko , Suzuki Miki , Kaname Shinya , Harigai Masayoshi 
Published: December 2021

ABSTRACT

Objectives
This study aimed to clarify the epidemiological and clinical features and treatment of patients with polyarteritis nodosa (PAN) in Japan.

Methods
We used the database of the Ministry of Health, Labour and Welfare (MHLW) of Japan in 2013 and 2014. We analysed 121 patients who were antineutrophil cytoplasmic antibodies negative among the patients certified as PAN according to the MHLW diagnostic criteria.

Results
The analysis included 60 males and 61 females, with a mean age of 52.9 ± 21.0 years. As a general manifestation, fever was observed in 53.7%. Regarding organ involvement, skin manifestations (82.6%), joint and muscle manifestations (75.2%), and neuropsychiatric manifestations (50.4%) were common. Male patients had a higher proportion of mononeuritis multiplex involving motor neuropathy than female patients. Elderly patients had a higher proportion of general and respiratory manifestations. Glucocorticoids were used for treatment in all patients, and 19.0% underwent methylprednisolone pulse. Concomitant immunosuppressants were used in 25.6%, one-third of whom received cyclophosphamide. Methylprednisolone pulse and cyclophosphamide were mostly used in patients with life-threatening organ involvement.

Conclusions
PAN developed in middle-aged people and led to numerous clinical manifestations. The common manifestations varied with age, and treatment was determined based on the type of organ involvement and disease severity.
Sturnira tildae (Chiroptera: Phyllostomidae)
Authors: Carneiro Lucas , Monteiro Leandro R , Nogueira Marcelo R 
Published: December 2021

Abstract
Sturnira tildae de la Torre, 1959, Tilda’s yellow-shouldered bat, is a phyllostomid with wide geographic distribution across South America. It inhabits preferably lowland mature rainforests, but also has been captured in modified vegetation and tropical savannas, where it is less abundant. Globally, it is listed as “Least Concern” (LC) by the International Union for Conservation of Nature and Natural Resources, but local red lists in southern Brazil have recorded this species as “Vulnerable,” mainly due to habitat destruction (Atlantic Forest deforestation).
Gut microbiota-mediated ferroptosis contributes to mercury exposure-induced brain injury in common carp
Authors: Zhang Yue , Zhang Peijun , Li Yuehong 
Published: December 2021

Abstract
Mercury is a heavy metal, which causes irreversible toxicity to fish and is found in aquatic environments around the world. The purpose of this study was to investigate the relative mechanism of mercury exposure on brain injury in common carp. The results showed that mercury exposure could induce brain injury and memory loss in common carp. Meanwhile, mercury exposure could induce neuronal ferroptosis. The ferroptosis inhibitor ferrostatin-1 attenuated mercury-induced brain injury. However, in an in vitro study, mercury did not induce ferroptosis, and ferrostatin-1 did not attenuate mercury-induced common carp brain cell death. Therefore, we speculated that mercury exposure-induced ferroptosis might occur through other pathways. Studies have shown that the gut microbiota contributes to the pathological process of heavy metal-induced injury. Therefore, we detected the effects of mercury exposure on the gut microbiota composition. The results showed that the composition and diversity of the gut microbiota were affected by mercury chloride. Surprisingly, we found that the abundance of Aeromonas, one of the most important pathogenic bacteria of fish, increased significantly. Subsequently, we isolated Aeromonas hydrophila from mercury-exposed carp and these bacteria could lead to brain injury and ferroptosis in common carp. These results suggested that mercury exposure-induced brain injury partly by increasing intestinal A. hydrophila, which led to ferroptosis in common carp.
Structure–activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB
Authors: Warren Garrett M , Meir Aviv , Wang Juncheng , Patel Dinshaw J , Greene Eric C , Shuman Stewart 
Published: December 2021

Abstract
Mycobacterial AdnAB is a heterodimeric helicase-nuclease that initiates homologous recombination by resecting DNA double-strand breaks. The AdnB subunit hydrolyzes ATP to drive single-nucleotide steps of 3′-to-5′ translocation of AdnAB on the tracking DNA strand via a ratchet-like mechanism. Trp325 in AdnB motif III, which intercalates into the tracking strand and makes a π stack on a nucleobase 5′ of a flipped-out nucleoside, is the putative ratchet pawl without which ATP hydrolysis is mechanically futile. Here, we report that AdnAB mutants wherein Trp325 was replaced with phenylalanine, tyrosine, histidine, leucine, or alanine retained activity in ssDNA-dependent ATP hydrolysis but displayed a gradient of effects on DSB resection. The resection velocities of Phe325 and Tyr325 mutants were 90% and 85% of the wild-type AdnAB velocity. His325 slowed resection rate to 3% of wild-type and Leu325 and Ala325 abolished DNA resection. A cryo-EM structure of the DNA-bound Ala325 mutant revealed that the AdnB motif III peptide was disordered and the erstwhile flipped out tracking strand nucleobase reverted to a continuous base-stacked arrangement with its neighbors. We conclude that π stacking of Trp325 on a DNA nucleobase triggers and stabilizes the flipped-out conformation of the neighboring nucleoside that underlies formation of a ratchet pawl.