bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Evaluation of bi-directional Roller Bearings for Seismic Isolation of Buildings Under Near-fault Earthquakes
Authors: Ortiz-Cano Nelson , González-Olaya Ricardo , Gaviria-Mendoza Carlos , Magluta Carlos , Roitman Ney 
Published: August 2021

Abstract
An advantage bidirectional sloped rolling type isolation device composed of multiple rollers in both orthogonal-in-plane directions is studied in this research. The analytical model of a single direction of roller bearing (RB) system is extended to a two-direction RB system. Also, a 3D linear-elastic frame element to build the finite element model is used to incorporate the response of the building model. Several experimental tests of a physical building model with and without an RB system are used to validate the numerical model. The model is used to assess the nonlinear response history analysis of a four-story multi-column building system with two different physical properties that represent buildings with low and high lateral stiffness when subjected to pairs of scaled near-fault earthquake records. The effect of the angle of inclination of bearing plates in the range of 1.0o to 4.0o and sliding friction force is also investigated in a parametric analysis to evaluate the performance of RB with supplementary damping mechanisms ranging from 0.0 to 0.5N/kg, i.e., friction force normalized with the structure mass. Results show that the proposed bi-directional RB system is suitable for reducing the seismic response of rigid and flexible multi-column structures. In particular, the RB system reduces structure acceleration responses by 5–85% in the flexible structure and 86–96% in the rigid structure. Furthermore, an angle of inclination of bearing plates greater than or equal to 3.0o is an advantage to ensure the self-centering capacity.
A network pharmacology study on the Cervix Prescription for treatment of Cervical Cancer
Authors: Ying Pian , Zhu Yingping 
Published: August 2021

Abstract
Purpose: Based on the method of network pharmacology to explore the mechanism of the Cervical Prescription(CP) in the treatment of cervical cancer(CC) . Methods: To obtain the active ingredients and potential targets of CP from the Traditional Chinese Medicine Systems Pharmacology database and analysis platform (TCMSP) ; To search for targets related to cervical cancer through the database, and map the CP and the targets; Screen the core Targets, a Chinese medicine compoundtarget network and STRING database was used to construct a protein-protein interaction network (PPI). The DAVID 6.8 online tool was used to perform gene ontology (GO) and kyoto encyclopedia of genes and genome (KEGG) pathway enrichment analyses of overlapping targets. Results: The CP contains 2 active ingredients, corresponding to 301 non-reactive targets; 10 GO biological process related items and 73 signal pathways were obtained. Conclusion: By constructing a network diagram of "components-targets-pathways", 1Project fund: Zhejiang Provincial Natural Science Foundation Project(CN) (LQ20H270016); Zhejiang Traditional Chinese Medicine Administration (CN) (2020ZB087). *Profile of the author: Zhu Yingping, (1987-), female, attending physician, from Ganzhou, Jiangxi Province, master's degree student, research direction: Chinese medicine prevention and treatment of gynecological malignancies; E-mail: zhuyingping_26@126.com this study revealed that CP can exert its efficacy through multiple components, multiple targets, and multiple pathways to achieve the purpose of preventing and treating CC.The network pharmacology-based approach in the present study showed promising potential for identifying the main therapeutic targets from TCM formulas. This study provides valuable information for TCM researchers and clinicians to better understand the main therapeutic targets and therapeutic roles of herbal decoctions in clinical settings.
Depletion of CD206+ tumour macrophages by mUNO targeted nanoconjugate inhibits tumourigenesis and dissemination in triple negative breast cancer
Authors: Lepland Anni , Malfanti Alessio , Haljasorg Uku , Asciutto Eliana , Pickholz Monica , Bringas Mauro , Đorđević Snežana , Salumäe Liis , Peterson Pärt , Teesalu Tambet , Vicent María , Scodeller Pablo 
Published: August 2021

Abstract
Chemotherapy is the standard of care for patients with triple negative breast cancer (TNBC), an aggressive breast cancer subtype with a poor prognosis. In many solid tumours, M2-skewed tumour-associated macrophages (TAMs) are known to promote progression, immunosuppression, relapse, and dissemination of the malignant disease. Although TAM depletion has been explored as an anticancer strategy, the currently available TAM depleting compounds suffer from poor efficacy and dose-limiting side effects. Here, we develop of a novel TAM-depleting agent that specifically targets CD206+ macrophages and show that it is efficacious as an anti-TNBC agent and well tolerated. This new TAM-depleting compound, called “OximUNO”, is a star-shaped polyglutamate decorated with the CD206-targeting peptide mUNO and carrying doxorubicin through a pH-responsive linker. In the orthotopic and experimental metastases of TNBC, fluorescent reporter mUNO-guided polyglutamate construct homed to CD206+ macrophages in the primary cancer lesions and at the sites of metastases. OximUNO displayed enhanced cytotoxicity towards primary M2 macrophages in vitro and exhibited no acute liver or kidney toxicity in vivo. In TNBC mouse models, OximUNO reduced the progression of primary breast cancer lesions and metastatic dissemination of malignant cells. Treatment with OximUNO had an immunomodulatory effect on the tumour microenvironment: besides reducing the number of CD206+ TAMs, it resulted in increased ratio of the CD8/FOXP3 expression. These studies suggest the potential utility of OximUNO based CD206+ TAM depletion strategies for the treatment of TNBC, and possibly, other types of solid tumours.
Synthesized Li2B4O7: Mg,Cu nanoparticles: a suitable thermoluminescence dosimeter for detection of high doses of gamma rays
Authors: Mehrabi Mohsen , Zahedifar Mostafa , hasanloo soheila , Nikmanesh hossein , Gheisari Rouhollah , li yangtao 
Published: August 2021

Abstract
Lithium tetraborate nanoparticles co-doped with various percentages of Cu and Mg impurities were synthesized through the combustion process. Scanning electron microscopy images along with X-Ray diffraction pattern confirmed the shape and structure of the products. The Williamson-Hall equation was used to measure the size of nanoparticles that resulted in approximately 47 nm for the crystallite size. The optical band gap of about 3.7 eV was obtained for the nanostructures from the UV-visible spectrum. Furthermore, the thermoluminescence features the samples under gamma irradiation were studied at ambient conditions. The highest thermoluminescence sensitivity achieved at 0.02 % wt Cu and 0.5 % wt Mg impurities simultaneously. The results show that the co-doped nanoparticles have a linear dose response up to an administrated dose of 30 kGy and about 10% of the thermoluminescence signal fades after 30 days of storage at room temperature.
Association between systemic lupus erythematosus and cancer: findings from cohort studies and Mendelian randomization analysis
Authors: Gu Dongqing , Tang Mingshuang , Cui Huijie , Zhang Min , Wang Yutong , Bai Ye , Wang Xin , Zhang Ben 
Published: August 2021

Abstract
Background

Observational studies suggested that systemic lupus erythematosus (SLE) was associated with an increased risk of cancer, however, the causal effect remains unclear. We aim to determine the causality between SLE and cancer using a meta-analysis and Mendelian randomization (MR) approach.
Methods

A systematic search was conducted using PubMed to identify cohort studies published before January 21, 2021. Meta-analysis was performed to calculate relative risk (RR) and corresponding 95% confidence intervals (CI), and the potentially causal relationships identified by observational studies were further validated using two-sample Mendelian randomization.
Results

Through meta-analysis of 43 cohort studies involving 231,499 patients, we observed an increased overall cancer risk among SLE patients (RR = 1.62, 95% CI, 1.47–1.79). Site-specific analysis suggested that SLE patients were associated with an increased risk of 17 cancers. Mendelian randomization analysis indicated that genetically predisposed SLE was causally associated with an increased risk of lymphoma (odds ratio = 1.0004, 95% CI, 1.0001–1.0007, P = 0.0035), whereas a decreased risk of bladder cancer (odds ratio = 0.9996, 95% CI, 0.9994–0.9998, P = 0.00004) in European ancestry. However, no relationship was observed between genetically predisposed SLE and risk of colon, pancreatic, lung, cervical and Non-melanoma skin cancer in European ancestry, liver cancer and lung cancer in Asian ancestry.
Conclusions

Findings from meta-analysis and Mendelian randomization analysis suggested that SLE might be causally associated with an increased risk of lymphoma. However, inconsistent results were observed between SLE and risk of bladder cancer.
The profile of menthol cigarette smokers in the months following the removal of these products from the market: a cross-sectional population survey in England
Authors: Kock Loren , Shahab Lion , Bogdanovica Ilze , Brown Jamie 
Published: August 2021

Abstract

IntroductionIn May 2020 the EU Tobacco Products Directive ban on the sale of menthol cigarettes was implemented in England. This study examined the prevalence of menthol cigarette smoking after the ban, according to sociodemographic and smoking characteristics.MethodsCross-sectional data came from a representative survey of current smokers (18+) in England (unweighted n = 2,681) between July/2020 and June/2021. The weighted prevalence of menthol cigarette smoking as a proportion of total cigarette smoking was calculated, log-binomial regression explored trends over time, and chi-squared statistics assessed the relationship between menthol smoking, sociodemographic and smoking characteristics. Sources of purchase of menthol cigarettes were explored.ResultsBetween July 2020 and June 2021, 15.7% (95%CI 14.5–17.1) of smokers reported smoking menthol cigarettes. The fitted non-linear trend supported no initial change followed by a possible reduction across April-June 2021 and fit the data better than linear and null (no change) models (χ2(2) = 2519.7, P = 0.06; χ2(3) = 2519.7, P = 0.006). Menthol cigarette smoking was more common among younger groups (16–24 = 25.2%; 25–34 = 19.9%) and women (19.4%). Menthol cigarette smokers showed lower cigarette dependence compared with other smokers. Past six-month purchases of menthol cigarettes from any illicit source declined from 30.1% in the last 6 months of 2020 to 17.5% in the first 6 months of 2021.ConclusionsA substantial minority of current smokers in England reported menthol cigarette smoking between July/2020 and June/2021, despite the ban, possibly reflecting mitigation of restrictions by a variety of licit means, such as legal menthol accessories. The reduction in menthol smoking across April-June 2021 warrants further monitoring.
UPAYA PEMERINTAH DESA DALAM MENSEJAHTERAKAN MASYARAKAT DESA SETELAH BERLAKUNYA UU NO. 06 TAHUN 2014 TENTANG DESA
Authors: M Muksin 
Published: August 2021

The concept of village development has changed since the passing of Law number 06 of 2014. These changes have had a major impact on the concept of village development ranging from broader authority granted to village governments to the authority of village financial management. All these authorities have demands and responsibilities to the village government to strive for the welfare of the village community. The welfare of the village community becomes mandatory after the enactment of Law number 06 of 2014 concerning the Village, implicitly or explicitly giving clear instructions and making guidelines to the village government to maximize all efforts in realizing the welfare of the village community either through physical infrastructure development or human resource development. Because the village is a miniature of the Republic of Indonesia,the benchmark of the success and the progress of Indonesiaare reflectedby the smallest entity in the scale of village government. The impact of development in the village will be directly felt by the village community as a whole and indirectly affect the progress of the Republic of Indonesia.
PENYETARAAN GENDER DALAM HAL PEMBAGIAN WARISAN
Authors: Amalia Endah Amalia 
Published: August 2021

Inheritance is the transfer of property owned by someone who has died and then given to someone else who has the right to inherit it. Sons should inherit more shares than daughters. But along with the development of an increasingly advanced era, there is a phenomenon of equal distribution of inheritance between sons and daughters. Under the pretext of gender equality, and emancipation of women, it is fair. This research was conducted to find out the views of Islamic law regarding the equal distribution of inheritance between sons and daughters. This research uses qualitative analysis using the literature study method. This research found that gender equality in the distribution of inheritance occurs with the times and its implementation still adheres to the applicable Islamic law. The differences in the distribution of inheritance between men and women are not caused by gender difference, but the differences in responsibilities imposed on men more than women.
Keywords: Equal, Gender, Inheritance.
PEMENUHAN HAK DAN TANGGUNG JAWAB KONSUMEN DAN PELAKU USAHA SEBAGAI UPAYA PERLINDUNGAN HUKUM MELALUI KONSEP PEMBERDAYAAN
Authors: Siswati Indri Hadi , Puspitasari Reni Dwi 
Published: August 2021

Often the losses experienced by consumers in conducting transactions are the result of ignoring the responsibilities of business actors as stipulated in the Consumer Protection Law Number 8 of 1999 concerning Consumer Protection. The losses also happen because consumers often do not have the courage to defend their rights due to the lack of courage and helplessness due to a one-sided take-or-leave-it contract that gives business actors more authority so that the two parties are not in a balanced and equal position. Therefore, empowering consumers by showing their rights and how to defend their rights is important. Likewise, with the empowerment of business actors which emphasizes the fulfillment of their responsibilities, it is possible that the products and / or services offered have a small possibility of detrimental to consumers. In return, it also benefits to business actors in increasing the level of marketing of their products.
Keywords: Empowerment, Consumers, Bussines Actors, Fulfillment or Rights and Responsibilities.
ANALISIS USHUL FIKIH MENGENAI KALENDAR ISLAM DALAM KONTEKSTUALISASI NASH-NASH HISAB DAN RUKYAT
Authors: Saifurrohman Ahmad , Azzafi Ashif 
Published: August 2021

In modern era, in line with the rapid development of astronomy, many new problems arise. For example, the issue in the Islamic calendar which has long been debated is the difference in determining the beginning of the month of Ramadan, Shawwal, and Zulhijjah or Arafat. From the above issue, what exactly the problem is the unification of the Islamic calendar and how the reckoning experts and astronomers in the effort to unify the Islamic calendar. To solve these problems requires the right way such as the infant method or textual analysis, the causation method, and the taufiki method.
Keywords: Unification of the Islamic Calendar, Islamic Calendar, Bayani, Causation, Taufiki, Interpretation.
HUKUMAN MATI BAGI ORANG YANG MURTAD DALAM PERSPEKTIF HADIS
Authors: Mutawali Muhammad 
Published: August 2021

Many Muslims who come out of their religion and embrace other religions with a variety of motives and reasons depending on their respective interests. This phenomenon seems to be a trend and lifestyle in the midst of the swift currents of globalization, democratic life, respect for Human right and religious freedom. In Islamic Criminal Law, apostasy (murtad) is a crime that is included in jarimah hudud. The punishment for apostates/riddah is the death penalty, and in the hereafter will get a reply in hell, this is in accordance with the message contained in the Qur'an and the Hadith of the Prophet Muhammad. This article explains the differences of opinion of the ulama regarding the punishment for the perpetrators of riddah / apostasy. Al-Qur'an does not specifically explain the punishment for apostates, it only stipulates the vanity of charity and in the hereafter will be given severe punishment. In the hadith of the Prophet which expressly punishes apostates with the death penalty. From the two sources of Islamic law as if there was a conflict. Therefore, it is very interesting to study considering that the problem of riddah is one of the problems in the study of Islamic criminal law which is always a concern of ulama and experts in contemporary Islamic law.
Keywords: Riddah/Apostasy, Death penalty, Jarimah, Ta`zir
HİCİV VE MİZAH AÇISINDAN 19. YÜZYILIN İKİNCİ YARISINDA İSTANBUL SOKAKLARINDA TEMİZLİK-DÜZEN SORUNLARI
Authors: ERDİNÇLİ İhsan 
Published: August 2021

Avrupa’da ilk olarak İngiltere özelinde 18. yüzyılın ikinci yarısından itibaren ortaya çıkan Sanayi Devrimi, yaklaşık bir asır sonra küresel etkiler meydana getirecek bir boyut kazanmıştır. Pek çok yönü olan modern çağın ortaya çıkardığı etkilerden biri de nüfus artışı ve yoğunluğuna paralel olarak temizlik sorunları karşısında bireyin daha yaşanılır kent hayatına olan isteğini kuvvetlendirmesidir. Devletler, değişen çağın olumsuz yansımalarıyla yine koşulların sunduğu imkânlardan faydalanarak çözüm bulmaya çalışmışlardır.
Osmanlı Devleti de modernleşme hareketleri kapsamında başta payitaht İstanbul olmak üzere Avrupa örneğinde daha yaşanılır kentler inşa etme yönünde düzenlemeler yapmıştır. Bu kapsamda kurulan Şehremaneti, öncelikle gayrimüslim ve Frenk nüfusuyla öne çıkan Beyoğlu’nda beledî hizmetleri uygulamaya başlamıştır. Daha sonra genişletilen beledî birimlerle sokakların temizliği, düzeni, genişletilmesi gibi hizmetler yerine getirilmeye çalışılmıştır. Konuyla ilgili klasik ve modern dönemde şehrin temizliğinin çeşitli yönlerini ele alan çalışmalar bulunmaktadır. Bu çalışma, 19. yüzyılın ikinci yarısında İstanbul örneğinde modern kentler inşasına yönelik başlatılan beledî hizmetlerin toplumdaki yansımalarını gazete, hatırat ve seyahatnameler ışığında eleştiri, hiciv ve mizah odaklı bir yaklaşımla belirlemeyi amaçlamaktadır. İnceleme dönemi, aynı zamanda İstanbul basınının oluşup çeşitlendiği, temizlik ve düzen sorunlarının tartışılmaya başlandığı bir zaman dilimini yansıtmaktadır. Bu doğrultuda toplumu oluşturan bireyin kendisini çepeçevre saran sorunlara karşı duyarsız kalmayarak şikâyet ve önerilerini basın aracılığıyla dile getirdiği görülmektedir.
EXPERIÊNCIA E REPRESENTAÇÃO DO ABANDONO E DO ARRUINAMENTO DO BAIRRO JARAGUÁ EM MACEIÓ/BRASIL
Authors: Gilcileide Rodrigues da Silva  
Published: August 2021

O estudo Geográfico de um recorte espacial, da cidade de Maceió, Estado de Alagoas (BR), versa acerca do abandono e do arruinamento dos espaços edificados. A finalidade consiste em entender como as pessoas experienciam e/ou representam o abandono e o arruinamento do bairro Jaraguá, institucionalizado como Zona Especial de Preservação Cultural. Apesar de ser uma zona de preservação cultural, os espaços em estado de abandono como casas, sobrados, armazéns e outras formas edificadas são perceptivos aos olhos do observador. A problemática nos instigou a entender: como as pessoas experienciam o abandono e o arruinamento? Assim, através de uma abordagem fenomenológica em Geografia, utilizou-se de narrativas de moradores e técnicos de órgãos públicos e privados situados no próprio bairro, para relatar suas experiências. Conclui-se que o abandono e o arruinamento são manifestados, enquanto um processo descontínuo, com evidências de um futuro incerto para aqueles que estão “ausentes” e presentes no bairro.
A IMPLEMENTAÇÃO DAS AÇÕES INCLUSIVAS PELO NAPNE E A CAPACITAÇÃO POR MEIO DOS CURSOS DE LIBRAS
Authors: Dorisvan da Silva Portela Antônia 
Published: August 2021

RESUMO

Pensando na acessibilidade e na inclusão de surdos nas dependências do Instituto Federal do Pará (IFPA) – Campus Santarém, buscamos desenvolver um Projeto de Extensão para o ensino da Língua de Sinais Brasileira nas dependências do instituto no período de 2018 à 2019, cujo público alvo foram servidores e alunos do IFPA, além de vagas ofertadas para alunos e professores externos à nstituição. O trabalho teve como objetivo contribuir com o ensino e aprendizagem da Língua de Sinais Brasileira, assim como sua estrutura gramatical e sua funcionalidade na sociedade. O projeto foi desenvolvido obedecendo a um cronograma de execução. Inicialmente levantamos o número de pessoas interessadas, em seguida a disponibilidade de dias e horários para que pudéssemos organizar o cronograma dos encontros, de acordo com a disponibilidade do instituto e dos interessados. O resultado foi satisfatório pelo número de participantes, fazendo-se necessária a repetição do projeto nos próximos anos.

Palavras chaves: Libras. Educação. – Inclusão do surdo. Libras – Capacitação.
ASSISTÊNCIA NUTRICIONAL MATERNO-INFANTIL NO CENÁRIO DA COVID-19
Authors: Teodósio Almeida de Melo Andressa , Rodrigues Carneiro Byanca , Artuanne Figueredo da Silva Esther , De Sousa Rebouças Amanda , Fernandes dos Santos Dametto Juliana 
Published: August 2021

O aleitamento materno e a alimentação complementar contribuem para a formação de hábitos saudáveis nos primeiros anos de vida e tais informações precisam ser divulgadas para gestantes, lactantes e profissionais de saúde, mesmo diante do isolamento social devido o coronavírus. Assim, esse relato tem como objetivo mostrar a criação de materiais educativos sobre o aleitamento materno e a introdução alimentar para crianças menores de 2 anos e sua divulgação em redes sociais no cenário da COVID-19. O trabalho resultou na produção de folders informativos e banner, que teve como referência principal o Guia Alimentar para Crianças Menores de 2 Anos. O material tornou-se um instrumento para a realização de ações de educação em Nutrição no cenário de isolamento social, contribuindo para a promoção continuada de ações em saúde e formação dos discentes do grupo de extensão.
Palavras-chave: aleitamento materno; alimentação complementar; COVID-19.