bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA damage-induced degradation of Sp1 promotes cellular senescence
Authors: Swift Michelle L. , Sell Christian , Azizkhan-Clifford Jane 
Published: September 2021

AbstractPersistent DNA damage (genotoxic stress) triggers signaling cascades that drive cells into apoptosis or senescence to avoid replicating a damaged genome. Sp1 has been found to play a role in double strand break (DSB) repair, and a link between Sp1 and aging has also been established, where Sp1 protein, but not RNA, levels decrease with age. Interestingly, inhibition ATM reverses the age-related degradation of Sp1, suggesting that DNA damage signaling is involved in senescence-related degradation of Sp1. Proteasomal degradation of Sp1 in senescent cells is mediated via sumoylation, where sumoylation of Sp1 on lysine 16 is increased in senescent cells. Taking into consideration our previous findings that Sp1 is phosphorylated by ATM in response to DNA damage and that proteasomal degradation of Sp1 at DSBs is also mediated by its sumoylation and subsequent interaction with RNF4, we investigated the potential contribution of Sp1’s role as a DSB repair factor in mediating cellular senescence. We report here that Sp1 expression is decreased with a concomitant increase in senescence markers in response to DNA damage. Mutation of Sp1 at serine 101 to create an ATM phospho-null mutant, or mutation of lysine 16 to create a sumo-null mutant, prevents the sumoylation and subsequent proteasomal degradation of Sp1 and results in a decrease in senescence. Conversely, depletion of Sp1 or mutation of Sp1 to create an ATM phosphomimetic results in premature degradation of Sp1 and an increase in senescence markers. These data link a loss of genomic stability with senescence through the action of a DNA damage repair factor.
Characterization of Mesenchymal Stem Cells Derived from Bisphosphonate-Related Osteonecrosis of the Jaw Patients’ Gingiva
Authors: Li Mengyu , Wang Jiajia , Yu Yejia , Zhou Yuqiong , Shi Yueqi , Zhang Wenjie , Son Geehun , Ge Jing , Zhao Jun , Yang Chi , Wang Shaoyi 
Published: September 2021

AbstractBisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition that specifically occurs in the oral cavity, characterized by retarded wound healing in oral mucosa accelerating the exposure of bone. Moreover, the pathological mechanism remains poorly understood. Gingival mesenchymal stem cells (GMSCs) play a critical role in gingival healing and soft tissue regeneration. Although previous studies have showed that bisphosphonates (BPs) are highly toxic to healthy GMSC, there is overall lack of direct evidence demonstrating the characterization of GMSCs derived from BRONJ patients. In present study, we isolated GMSCs for the first time from the central area of BRONJ patients’ gingiva (center-BRONJ GMSCs) and the peripheral area (peri-BRONJ GMSCs), and found that they exhibited decreased proliferation, adhesion, migration capacities and underwent early apoptosis in vitro compared control GMSCs. Notably, the central and peripheral BRONJ GMSCs transplantation in a mice excisional skin model also displayed lower cell survival rate and poor healing effects than that of controls. Mechanistically, TGF-β1 signaling pathway was suppressed not only in BRONJ patients’ gingival lesions but also in BRONJ GMSCs transplantation animal model. The results above suggested that under the microenvironment of BRONJ patients, the dysfunction of GMSCs and the suppressed TGF-β1 signaling pathway may be the vital factors in impaired gingival healing, thus contributing to persistent exposure of underlying bone and development of BRONJ. This study provides new insights into the prevention for BRONJ by improving the functions of GMSCs and upregulating TGF-β1 in accelerating gingival wound healing.
Graphical Abstract
Schematic illustration of the dysfunction of BRONJ GMSCs in vitro and BRONJ GMSCs transplantation in a mice skin model delaying cutaneous wound healing mainly via suppressing TGF-β1 signaling pathway.
Navigating Contradictory Narratives on Sexuality Between the School and the Mosque in Four Muslim Communities in the Netherlands
Authors: Kosar Altinyelken Hulya , Akhtar Yusra , Selim Nazek 
Published: September 2021

AbstractThis qualitative study seeks to examine the sexuality-related values and norms that Muslim youth are taught and socialised into at non-formal Islamic education settings, compares these with values and norms conveyed at secondary schools, and then identifies the ways in which Muslim youth navigate these distinct messages and competing pressures around this subject. The data are based on 62 semi-structured in-depth interviews with young adults and secondary school students from four Muslim communities in the Netherlands (Turkish, Moroccan, Pakistani and Egyptian). The study reveals that explicit messaging as well as institutional practices in mosques convey a specific narrative about proper conduct between the sexes that prohibits sexual conduct before marriage, and in some cases, even any form of touching or socialising. This collides with the institutional practices and educational content in mainstream secondary schools, which are co-educational and provide sexuality education. Three strands of attitudinal choices young Muslims make are identified: opting for chastity, re-negotiating the norm, and embracing romantic entanglements, all having different ramifications for the wellbeing and relationships of these young people.
The Biopsychosocial Model and the Sex-Positive Approach: an Integrative Perspective for Sexology and General Health Care
Authors: Nimbi Filippo Maria , Galizia Roberta , Rossi Roberta , Limoncin Erika , Ciocca Giacomo , Fontanesi Lilibeth , Jannini Emmanuele Angelo , Simonelli Chiara , Tambelli Renata 
Published: September 2021

Abstract
Introduction
The Biopsychosocial model (BPS) represents a comprehensive paradigm of consolidated practices. Although it has been outlined as the gold standard in sexology, its implementation is often challenging. The sex-positive approach is a ground-breaking movement that is gaining popularity all over and is focused on the recognition of different sexual expressions as valid, consensual, healthy, and meaningful. However, a pragmatic implementation of this approach is still missing.

Methods
A critical review was conducted based on bibliographic research on Medline, PubMed, EBSCO, Cochrane Library, Scopus and Web of Science on relevant articles published from January 2011 to July 2021.

Results
A total of 116 papers were included in the following review, indicating an increasing body of research about BPS and sex-positive frameworks during the last 10 years. One of the main limitations in the BPS is the scarce attention paid to socio-cultural factors involved in sexual expressions, such as the role of negative attitudes towards sexuality that may affect health care professionals’ work. An application of the sex-positive approach to the BPS model may bring greater attention to the needs, values and desires of the individual, as well as allow a new knowledge and understanding of sexuality within a broader spectrum, including diversities and pleasures.

Conclusions
The sex-positive approach represents a viable path that entails the willingness of health care professionals to get involved actively; criticize their personal attitudes, beliefs, and knowledge about sex and work hard to improve their practice in sexology.

Policy Implications
A discussion of the possible fruitful integration between the BPS and the sex-positive approach is presented, highlighting practical applications in research, clinical practice, training and sex education and giving possible directions for future studies and policies.
Case study on the environmental impact and efficiency of travel
Authors: Otero Evelyn , Ringertz Ulf 
Published: September 2021

AbstractTraveling and possible impact on climate and environment are currently under intense debate, and air travel in particular is often in question due to the use of fossil fuels. Electric propulsion has therefore become very popular but the energy sources for electricity generation should as well be taken into consideration. On the other hand, the social aspect of traveling is usually forgotten and should be also included for a complete sustainability analysis. In this study, the business trip from Stockholm to Bordeaux experienced by airplane and train is analyzed. Though the journey by airplane generated six and a half times more CO2emissions than the journey by train on a per-passenger basis, this latter resulted in a 35-h journey compared to seven, and a cost up to eight and a half times more expensive than the airplane. The trip is defined as an optimization problem with focus on environmental, economic, and social impact to define acceptable trade-offs. The critical criteria for transportation mode choice were identified as the environment, time and comfort, and a value model for business travel mode optimization is proposed, integrating as well a personal value.
The Recording Industry as the Enemy? A Case Study of Early West German Metal Music
Authors: Herbst Jan-Peter 
Published: September 2021

AbstractRock and metal music have a complex relationship with the entertainment industries. They rely on commodified products but are also cautious towards the capitalist system with its instrumentalist mechanisms. This article examines early metal music from West Germany in the 1980s with its rock precursors in the 1970s to shed light on the music industry’s positive side other than the commonly portrayed enemy or villain image. Using journalistic sources, including magazines, biographies, documentaries, besides the music release database Discogs, the research reconstructs the independent recording industry for metal, examining key record companies, distribution channels and production staff, as well as their principles and intentions. The findings suggest that in the formative phase of German metal, the boundaries were blurred between fans, artists and entrepreneurs, most acting out of a passion for music. Fan practices, such as music-making, journalistic writing or tape trading, became serious leisure careers, eventually enabling some of the bands, journalists and entrepreneurs to make a living from their metal-related activities; others remained “semi-professional”. Communal spirit characterised German metal, and most of “the industry” worked together with the scene. The joint efforts made it possible for Germany to develop from a weak production location for subcultural rock music compared to the dominant cultures of the USA and UK to one of the leading recording industries for metal music. Rather than “the enemy” with manipulative intentions, the independent metal industry was a cultural intermediary and enabler of subcultural production and consumption.
Social Representations of Heroes: Triggers from the Past, Values in the Present, Patterns for the Future
Authors: Bigazzi Sára , Csernus Fanni , Siegler Anna , Bokrétás Ildikó , Serdült Sára , Ilea Izabella , Giourga Afroditi , Kahraman Melike , Takács Bálint 
Published: September 2021

AbstractThe representations of heroes and the heroic acts point to social values, norms, and morality of the present, creating a bridge between the past and a potential future. In this paper, a cross-cultural explorative study of heroes is presented aiming to explore general tendencies and possible patterns related to the different social contexts. Participants were reached from seven countries via social media (N = 974) for corpus construction. We asked by their choice of hero, national hero, and desired heroic action in their respective countries. A thematic analysis was conducted. Results show that there is a high rate of no choice, while among the chosen the prototypical hero is a lone moral man acting in the private (family) or public sphere (political actors). Both spheres offer the naturalization of the hero. There is a dialogical frame between the exceptional and the ordinary. Chosen heroes are dominantly contemporary males’ family members or political figures. While the purpose attributed to the personal hero is to maintain stability, the purpose attributed to the heroic actions of the public sphere is to obtain change. Similarities and differences between the seven subcorpuses are also described.
The effect of severe plastic deformation on the IF steel properties, evolution of structure and crystallographic texture after dual rolls equal channel extrusion deformation
Authors: Jabłońska M. B. , Kowalczyk K. , Tkocz M. , Chulist R. , Rodak K. , Bednarczyk I. , Cichański A. 
Published: September 2021

Abstract
This paper presents some results of the influence of severe plastic deformation on the microstructure evolution, grain refinement aspect, and mechanical properties of ultra-low carbon steel. Ti-stabilized experimental IF steel was deformed at a room temperature with unconventional SPD process—dual rolls equal channel extrusion (DRECE). Mechanical properties and structure of ferritic steel in initial state and after selected steps of deformation were investigated. The mechanical properties were determined by static tensile tests carried out at a room temperature and microhardness research. The structural investigations involved using scanning transmission electron microscopy observations, electron back scattered diffraction and measurements of the crystallographic texture. The DRECE process affects the evolution of the structure. The microstructural investigations revealed that the processed strips exhibited a dislocation cell and grain structures with mostly low angle grain boundaries. The electron backscattering diffraction (EBSD) examination showed that the processed microstructure is homogeneous along the strips thickness. The mechanical properties of the DRECE-processed IF steel strips increased with an increase the number of passes.
Effective and responsible marketing of online sports gambling to young adults in the UK
Authors: Dunlop Patrick , Ballantyne Erica E. F. 
Published: September 2021

AbstractIn an industry that has experienced rapid growth for a number of years, where product differentiation is minimal, the marketing tactics of online sports gambling (OSG) bookmakers are likely to push the boundaries of what can be considered responsible, as companies seek to stand out from competitors and take advantage of industry growth. This research aims to explore how the marketing tactics of OSG companies shape the gambling habits of young adult consumers, and whether this demographic considers these tactics responsible. Recommendations are made on how online bookmakers can remain responsible in their marketing to young adults. Findings revealed that the primary motivation behind young adults’ recreational gambling was the excitement induced through participation. Further, young adults’ OSG bookmaker preference is influenced by promotional offers for existing customers. Results from the study indicate that in general, young adults do not deem the varied marketing techniques employed by OSG companies as irresponsible practices. However there were concerns regarding the potential impact of the continued increase in OSG marketing on problem gamblers and children (under 18).
Strengthening producer organizations to increase market access of smallholder farmers in Uganda
Authors: Hill Ruth Vargas , Maruyama Eduardo , Olapade Markus , Frölich Markus 
Published: September 2021

AbstractSmallholder agriculture in Sub-Saharan Africa is largely exposed to pervasive market failures, translating into missed opportunities and sub-optimal economic behavior. These failures can partly be traced to the importance of economies of scale in procuring inputs and marketing produce, where smallholders face disproportionately high transaction costs. Producer organizations could help to lessen transaction costs; however, only a few farmers in Uganda sell through them. We introduce two interventions aimed at promoting marketing via producer organizations: cash on delivery, and information on sales, and analyze their impacts in an RCT design: We find that providing cash on delivery increases the probability that a member chooses to sell through the group, and hence the volumes bulked by each group. This increase in volumes appears to have enabled groups to secure higher prices for their produce. No significant effect could be found for providing information on sales.
Relatedness within and between Agta residential groups
Authors: Dyble Mark , Migliano Andrea Bamberg , Page Abigail E. , Smith Daniel 
Published: September 2021

AbstractTheoretical models relating to the evolution of human behaviour usually make assumptions about the kinship structure of social groups. Since humans were hunter–gatherers for most of our evolutionary history, data on the composition of contemporary hunter–gatherer groups has long been used to inform these models. Although several papers have taken a broad view of hunter–gatherer social organisation, it is also useful to explore data from single populations in more depth. Here, we describe patterns of relatedness among the Palanan Agta, hunter–gatherers from the northern Philippines. Across 271 adults, mean relatedness to adults across the population isr =0.01 and to adult campmates isr =0.074, estimates that are similar to those seen in other hunter–gatherers. We also report the distribution of kin across camps, relatedness and age differences between spouses, and the degree of shared reproductive interest between camp mates, a measure that incorporates affinal kinship. For both this this measure (s) and standard relatedness (r), we see no major age or sex differences in the relatedness of adults to their campmates, conditions that may reduce the potential for conflicts of interest within social groups.
Solidity effects on the performance of vertical-axis wind turbines
Authors: Miller Mark A. , Duvvuri Subrahmanyam , Hultmark Marcus 
Published: September 2021

Abstract
The variety of configurations for vertical-axis wind turbines (VAWTs) make the development of universal scaling relationships for even basic performance parameters difficult. Rotor geometry changes can be characterized using the concept of solidity, defined as the ratio of solid rotor area to the swept area. However, few studies have explored the effect of this parameter at full-scale conditions due to the challenge of matching both the non-dimensional rotational rate (or tip speed ratio) and scale (or Reynolds number) in conventional wind tunnels. In this study, experiments were conducted on a VAWT model using a specialized compressed-air wind tunnel where the density can be increased to over 200 times atmospheric air. The number of blades on the model was altered to explore how solidity affects performance while keeping other geometric parameters, such as the ratio of blade chord to rotor radius, the same. These data were collected at conditions relevant to the field-scale VAWT but in the controlled environment of the lab. For the three highest solidity rotors (using the most blades), performance was found to depend similarly on the Reynolds number, despite changes in rotational effects. This result has direct implications for the modelling and design of high-solidity field-scale VAWTs.
ATP-binding cassette transporters ABCF2 and ABCG9 regulate rice black-streaked dwarf virus infection in its insect vector, Laodelphax striatellus (Fallén)
Authors: Yang Yuanxue , Wang Aiyu , Wang Man , Zhang Yun , Zhang Jianhua , Zhao Ming 
Published: September 2021

AbstractThe majority of plant viral disease is transmitted and spread by insect vectors in the field. The small brown planthopper, Laodelphax striatellus (Fallén), is the only efficient vector for rice black-streaked dwarf virus (RBSDV), a devastating plant virus that infects multiple grain crops, including rice, maize, and wheat. Adenosine triphosphate (ATP)-binding cassette (ABC) transporters participate in various biological processes. However, little is known about whether ABC transporters affect virus infection in insects. In this study, RBSDV accumulation was significantly reduced in L. striatellus after treatment with verapamil, an effective inhibitor of ABC transporters. Thirty-four ABC transporter genes were identified in L. striatellus and expression analysis showed that LsABCF2 and LsABCG9 were significantly upregulated and downregulated, respectively, after RBSDV infection. LsABCF2 and LsABCG9 were expressed during all developmental stages, and LsABCG9 was highly expressed in the midgut of L. striatellus. Knockdown of LsABCF2 promoted RBSDV accumulation, while knockdown of LsABCG9 suppressed RBSDV accumulation in L. striatellus. Our data showed that L. striatellus might upregulate the expression of LsABCF2 and downregulate LsABCG9 expression to suppress RBSDV infection. These results will contribute to understanding the effects of ABC transporters on virus transmission and provide theoretical basis for virus management in the field.
PLATO,STATESMAN275D8–E1
Authors: Politis Vasilis 
Published: September 2021

AbstractIn his dialogueStatesman(=Plt.), Plato first sets out one way of thinking of the statesperson, on the model of a nurturer of a herd such as a shepherd; then he sets out a very different way of thinking of him, on the model of a weaver of a social fabric. Critics have long been wondering whether Plato wants to combine the two models or, on the contrary, to abandon the nurturing model in favour of the weaving model.This article shows that a particular passage in the dialogue, 275d8–e1, is crucial for this question. As this passage is understood by all commentators and translators, it says that the statesperson is not a nurturer. This ought to have settled the question. But the article argues that we cannot read the passage like that. For an adjacent passage, 275b1–7, says that the statesperson is a nurturer. There is no way out of this contradiction, unless we reconsider the traditional reading of 275d8–e1.The article defends a different reading of 275d8–e1, which avoids the contradiction. On this new reading, the passage does not say that the statesperson is not a nurturer, it says that her/his being a nurturer is not the grounds for her/him deserving the title ‘statesperson’.
NOTHING BUT RHETORIC? RHETORIC, PRAGMATICS AND MYTH-MAKING IN THE AGŌN OF EURIPIDES’ ALCESTIS
Authors: Martin Gunther 
Published: September 2021

AbstractThis paper draws on Euripides’ Alcestis to propose a new way of approaching the tragic agōn. It reads the debate scene of that play not as a rhetorical showpiece but as a piece of dialogue and an interaction that follows the principles of communicative pragmatics. In this interpretation Admetus and Pheres do not aim to persuade each other about whether it would have been right for Pheres to sacrifice his life for his son; instead, father and son are engaged in redefining their relationship, at the same time hurting each other as much as possible. Therefore, analyses that focus on ethical arguments concerning Pheres’ refusal to die and on how they reflect on the two persons' characters fail to capture an essential aspect of the quarrel. If, however, the communicative nature of the agōn is taken into consideration, illogical and seemingly idiosyncratic passages of the speeches can be explained as functional, and its transformed purpose chimes with Euripides’ rearrangement of the traditional myth, as he places the debate after Alcestis’ death.