bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of 1738 Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China
Authors: Ma Xiao , Gao Yujing , Di Lingling , Ma Hanning , Mei Bin , Zhang Junjian , Wang Amei , Feng Ke , Yang Lishan , Chen Zhongwei 
Published: April 2021

AbstractObjective:Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been discovered in Wuhan and spread rapidly across China and worldwide. Characteristics of infected patients are needed to get insight into the full spectrum of the disease.Methods:Epidemiological and clinical information of 1738 diagnosed patients during February 7-26, 2020 in Wuhan Dongxihu Fangcang Hospital were analyzed. A total of 709 patients were followed up on symptom, mental health, isolation site, and medication after discharge.Results:There were 852 males and 886 females in the cohort. The average age of the patients was 48.8 y. A total of 79.98% of the patients were from Wuhan, Hubei Province. The most common initial symptoms were fever, cough, and shortness of breath. Among all the patients, 1463 had complications, with respiratory distress as the most common complication. The average duration of hospitalization was 15.95 ± 14.69 d. The most common postdischarge symptom is cough. After discharge, most patients were full of energy and chose hotel as their self-isolation site. Coronavirus disease 2019 (COVID-19) Chinese medicine No.2 prescription is the medication used most commonly by the patients after discharge.Conclusions:The population is generally susceptible to SARS-CoV-2. After receiving aggressive treatment of combined Chinese and Western medicine, most patients had a good prognosis and mental health after discharge.
LAW, RELIGION, AND SAME-SEX RELATIONS IN AFRICA
Authors: Green M. Christian 
Published: April 2021

Some years back, around 2013, I was asked to write an article on the uses of the Bible in African law. Researching references to the Bible and biblical law across the African continent, I soon learned that, besides support for arguments by a few states in favor of declaring themselves “Christian nations,” the main use was in emerging debates over homosexuality and same-sex relationships—almost exclusively to condemn those relationships. In January 2013, the newly formed African Consortium for Law and Religion Studies (ACLARS) held its first international conference at the University of Ghana Legon. There, African sexuality debates emerged forcefully in consideration of a paper by Sylvia Tamale, then dean of the Makarere University School of Law in Uganda, who argued pointedly, “[P]olitical Christianity and Islam, especially, have constructed a discourse that suggests that sexuality is the key moral issue on the continent today, diverting attention from the real critical moral issues for the majority of Africans . . . . Employing religion, culture and the law to flag sexuality asthebiggest moral issue of our times and dislocating therealissue is a political act and must be recognised as such.”
Effect of transcranial direct current stimulation on in-vivo assessed neuro-metabolites through magnetic resonance spectroscopy: a systematic review
Authors: Chhabra Harleen , Thimmashetty Vani Holebasavanahalli , Shivakumar Venkataram , Venkatasubramanian Ganesan , Narayanswamy Janardhanan C. 
Published: April 2021

AbstractObjectives:Previous studies have examined the effect of transcranial direct current stimulation (tDCS) on the in-vivo concentrations of neuro-metabolites assessed through magnetic resonance spectroscopy (MRS) in neurological and psychiatry disorders. This review aims to systematically evaluate the data on the effect of tDCS on MRS findings and thereby attempt to understand the potential mechanism of tDCS on neuro-metabolites.Methods:The relevant literature was obtained through PubMed and cross-reference (search till June 2020). Thirty-four studies were reviewed, of which 22 reported results from healthy controls and 12 were from patients with neurological and psychiatric disorders.Results:The evidence converges to highlight that tDCS modulates the neuro-metabolite levels at the site of stimulation, which, in turn, translates into alterations in the behavioural outcome. It also shows that the baseline level of these neuro-metabolites can, to a certain extent, predict the outcome after tDCS. However, even though tDCS has shown promising effects in alleviating symptoms of various psychiatric disorders, there are limited studies that have reported the effect of tDCS on neuro-metabolite levels.Conclusions:There is a compelling need for more systematic studies examining patients with psychiatric/neurological disorders with larger samples and harmonised tDCS protocols. More studies will potentially help us to understand the tDCS mechanism of action pertinent to neuro-metabolite levels modulation. Further, studies should be conducted in psychiatric patients to understand the neurological changes in this population and potentially unravel the neuro-metabolite × tDCS interaction effect that can be translated into individualised treatment.
Holocene coastal landscape development in response to rising sea level in the Central Wadden Sea coastal region
Authors: Karle Martina , Bungenstock Friederike , Wehrmann Achim 
Published: April 2021

AbstractThe Holocene sea-level rise has led to significant changes in present-day coastal zones through multifold retrogradational and slightly progradational displacements of the mainland coastline. During the course of this postglacial transgression, sediments characteristic of coastal environments accumulated first in palaeovalleys of the pre-Holocene landscape and later on the subsequently developed coastal plain. Based on a compilation of sedimentological, lithological and litho-chronostratigraphical data of more than 1200 sediment cores, we generated four palaeogeographic maps of the coastal zone of the central Wadden Sea to document with a high spatial resolution the landscape changes during characteristic phases of the Holocene sea-level rise, i.e. the periods 8600–6500 cal BP, 6500–2700 cal BP, 2700–1500 cal BP and 1500–1000 cal BP. Along three cross-sections, representing different hydrodynamic conditions and exposure, we exemplify how the Holocene landscape development and sedimentary facies types are controlled by the local palaeorelief, sea-level changes, sediment supply, accommodation space, the morphodynamic impact of channel shifts, and their erosion base. This leads to a better understanding of main factors controlling the local depositional processes of the coastal landscape along the central Wadden Sea during the Holocene transgression.
Landscape changes and human–landscape interaction during the first millennium AD in the Netherlands
Authors: Pierik Harm Jan 
Published: April 2021

Abstract
The first millennium AD encompasses the Roman period (12 BC to AD 450) and the Early Middle Ages (AD 450 to 1050). In the Netherlands, this millennium saw population growth, steep decline and subsequent revival. In addition, many changes occurred in the physical landscape, marking a transition from a mainly natural prehistorical lowland landscape to an increasingly human-affected landscape. This paper synthesises the main landscape changes and human–landscape interactions in the Netherlands during this dynamic period. The degree of landscape change is compared between the coastal plain, the delta and the Pleistocene sand area.
Human activities caused major often unintended geomorphological changes in all studied landscapes. Landscape sensitivity to human impact, however, strongly varied as a function of preceding landscape state. The most prominent changes took place in many parts of the coastal plain, where back-barrier peatlands transformed into open tidal basins. Presence of compaction-prone peat and intensified artificial drainage led to subsidence. This precondition and slow anthropogenic forcing combined, made the area more sensitive to stochastically occurring storms, which could serve as tipping points for large-scale drowning. Eventually, major peatlands turned into tidal areas that for many centuries would remain unsuitable for habitation. Human-induced peatland subsidence also led to the formation of the new Hollandse IJssel and Lek river branches. This marked a major reorganisation of the river network in the lower Rhine–Meuse delta. In the middle and upstream parts of the delta, the landscape was more stable. Yet, settlements on the natural levees show adaption to increasing flooding frequency from the Late Roman period onwards. The settlements shifted towards higher positions, while route networks between them largely remained intact. Smaller-scale landscape changes were found in the Pleistocene sand area. Here, local sand drifting occurred, most frequently occurring close to human movement corridors. Drift sand intensity became larger as population density increased after c.AD 900.
HEIDELBERG RADIOCARBON LAB – ESTABLISHING A NEW CARBON DIOXIDE EXTRACTION LINE FOR CARBONATE SAMPLES
Authors: Therre S , Proß L , Friedrich R , Trüssel M , Frank N 
Published: April 2021

ABSTRACTTo achieve high-precision and reproducible results from radiocarbon (14C) dating of carbonate samples in paleoclimate research, a new CO2 extraction line was designed, constructed, and characterized at the Heidelberg Radiocarbon Lab of the Institute of Environmental Physics, Heidelberg. The setup includes a circular glass-tube design, which is operated at vacuum pressure levels of the order of 10–5 mbar. The efficiency of the extraction process was assessed, showing significantly favorable conditions for solid piece samples (99.58 ± 4.69)% over powdered samples (88.28 ± 10.03)%. Process blank values are below 0.2 pMC apparent 14C activity. Repeated measurements of IAEA C2 standards with an average value of (41.09 ± 0.23) pMC attest high accuracy and reproducibility of the instrument. Six consecutive samples of 6 to 12 mg carbonate mass can be processed in one run of roughly 2.5 hours. Thus, the new setup contributes to time-efficient and reproducible radiocarbon dating results for paleoclimate research at the Institute of Environmental Physics. In a first application, Dead Carbon Fraction (DCF) values of a Holocene alpine stalagmite from Schratten Cave are presented, revealing extraordinarily high offsets between atmospheric and stalagmite 14C with DCF values between (49.4 ± 0.4)% and (61.6 ± 0.4)%.
SEMANTIC SATIATION FOR POETIC EFFECT
Authors: Anderson Daniel 
Published: April 2021

AbstractThis article argues that the defamiliarization caused by extensive repetition, termed ‘semantic satiation’ in psychology, was used by ancient poets for specific effects. Five categories of repetition are identified. First, words undergo auditory deformation through syllable and sound repetition, as commonly in ancient etymologies. Second, a tradition of emphatic proper-name repetition is identified, in which the final instance of the name is given special emphasis; this tradition spans Greek and Latin poetry, and ultimately goes back to the Nireus entry in the Catalogue of Ships. Third, repetition is used for wordplay, where the final instance of the repeated term not only is emphasized but also incurs some change to its meaning or shape. Fourth, the incantatory repetition of divine names in hymns and cultic invocations amplifies a sense of divine presence behind and beyond the repetend. Fifth, repetition of half and full lines by different speakers in Old Comedy serves to undercut and parody the original sense of the repeated words. Extensive repetition in ancient literature was never merely ornamental but was used for a range of specific auditory and semantic effects with distinct and identifiable structures.
Multiplicities, invariant subspaces and an additive formula
Authors: Chattopadhyay Arup , Sarkar Jaydeb , Sarkar Srijan 
Published: April 2021

AbstractLet$T = (T_1, \ldots , T_n)$be a commuting tuple of bounded linear operators on a Hilbert space$\mathcal{H}$. The multiplicity of$T$is the cardinality of a minimal generating set with respect to$T$. In this paper, we establish an additive formula for multiplicities of a class of commuting tuples of operators. A special case of the main result states the following: Let$n \geq 2$, and let$\mathcal{Q}_i$,$i = 1, \ldots , n$, be a proper closed shift co-invariant subspaces of the Dirichlet space or the Hardy space over the unit disc in$\mathbb {C}$. If$\mathcal{Q}_i^{\bot }$,$i = 1, \ldots , n$, is a zero-based shift invariant subspace, then the multiplicity of the joint$M_{\textbf {z}} = (M_{z_1}, \ldots , M_{z_n})$-invariant subspace$(\mathcal{Q}_1 \otimes \cdots \otimes \mathcal{Q}_n)^{\perp }$of the Dirichlet space or the Hardy space over the unit polydisc in$\mathbb {C}^{n}$is given by\[ \mbox{mult}_{M_{\textbf{{z}}}|_{ (\mathcal{Q}_1 \otimes \cdots \otimes \mathcal{Q}_n)^{{\perp}}}} (\mathcal{Q}_1 \otimes \cdots \otimes \mathcal{Q}_n)^{{\perp}} = \sum_{i=1}^{n} (\mbox{mult}_{M_z|_{\mathcal{Q}_i^{{\perp}}}} (\mathcal{Q}_i^{\bot})) = n. \]A similar result holds for the Bergman space over the unit polydisc.
Using distance sampling with camera traps to estimate the density of group-living and solitary mountain ungulates
Authors: Pal Ranjana , Bhattacharya Tapajit , Qureshi Qamar , Buckland Stephen T. , Sathyakumar Sambandam 
Published: April 2021

AbstractThroughout the Himalaya, mountain ungulates are threatened by hunting for meat and body parts, habitat loss, and competition with livestock. Accurate population estimates are important for conservation management but most of the available methods to estimate ungulate densities are difficult to implement in mountainous terrain. Here, we tested the efficacy of the recent extension of the point transect method, using camera traps for estimating density of two mountain ungulates: the group-living Himalayan blue sheep or bharalPseudois nayaurand the solitary Himalayan musk deerMoschus leucogaster. We deployed camera traps in 2017–2018 for the bharal (summer: 21 locations; winter: 25) in the trans-Himalayan region (3,000–5,000 m) and in 2018–2019 for the musk deer (summer: 30 locations; winter: 28) in subalpine habitats (2,500–3,500 m) in the Upper Bhagirathi basin, Uttarakhand, India. Using distance sampling with camera traps, we estimated the bharal population to be 0.51 ± SE 0.1 individuals/km2(CV = 0.31) in summer and 0.64 ± SE 0.2 individuals/km2(CV = 0.37) in winter. For musk deer, the estimated density was 0.4 ± SE 0.1 individuals/km2(CV = 0.34) in summer and 0.1 ± SE 0.05 individuals/km2(CV = 0.48) in winter. The high variability in these estimates is probably a result of the topography of the landscape and the biology of the species. We discuss the potential application of distance sampling with camera traps to estimate the density of mountain ungulates in remote and rugged terrain, and the limitations of this method.
Simulation-based evaluation of school reopening strategies during COVID-19: A case study of São Paulo, Brazil
Authors: Cruz E. H. M. , Maciel J. M. , Clozato C. L. , Serpa M. S. , Navaux P. O. A. , Meneses E. , Abdalah M. , Diener M. 
Published: April 2021

Abstract
During the coronavirus disease 2019 (COVID-19) pandemic, many countries opted for strict public health measures, including closing schools. After some time, they have started relaxing some of those restrictions. To avoid overwhelming health systems, predictions for the number of new COVID-19 cases need to be considered when choosing a school reopening strategy. Using a computer simulation based on a stochastic compartmental model that includes a heterogeneous and dynamic network, we analyse different strategies to reopen schools in the São Paulo Metropolitan Area, including one similar to the official reopening plan. Our model allows us to describe different types of relations between people, each type with a different infectiousness. Based on our simulations and model assumptions, our results indicate that reopening schools with all students at once has a big impact on the number of new COVID-19 cases, which could cause a collapse of the health system. On the other hand, our results also show that a controlled school reopening could possibly avoid the collapse of the health system, depending on how people follow sanitary measures. We estimate that postponing the schools' return date for after a vaccine becomes available may save tens of thousands of lives just in the São Paulo Metropolitan Area compared to a controlled reopening considering a worst-case scenario. We also discuss our model constraints and the uncertainty of its parameters.
Thermal requirements and germination niche breadth of Polygonum ferrugineum Wedd. from southeastern Brazil
Authors: Marques Andréa R. , Gonçalves Ana Letícia B. R. , Santos Fábio S. , Batlla Diego , Benech-Arnold Roberto , Garcia Queila S. 
Published: April 2021

AbstractTemperature may regulate seed dormancy and germination and determine the geographical distribution of species. The present study investigated the thermal limits for seed germination of Polygonum ferrugineum (Polygonaceae), an aquatic emergent herb distributed throughout tropical and subtropical America. Seed germination responses to light and temperature were evaluated both before (control) and after stratification at 10, 15 and 20°C for 7, 14 and 28 d. Germination of control seeds was ~50% at 10 and 15°C, and they did not germinate from 20 to 30°C. The best stratification treatment was 7 d at 10°C, where seed germination was >76% in the dark for all temperatures, except at 30°C, and < 60% in light conditions. A thermal time approach was applied to the seed germination results. Base temperature (Tb) was 6.3°C for non-dormant seeds and optimal temperature (To) was 20.6°C, ceiling temperature (Tc (<50)) was 32.8°C, and thermal time requirement for 50% germination was 44.4°Cd. We concluded that a fraction of P. ferrugineum seeds is dormant, has a narrow thermal niche to germinate (10 and 15°C) and that cold stratification (10°C) alleviated dormancy and amplified the thermal range permissive for germination of the species. Consequently, P. ferrugineum is expected to occur in colder environments, for example, at high altitudes. Higher temperatures decrease the probabilities of alleviate dormancy and the ability of their seeds to germinate.
Comparison of Safety and Tolerability of Deutetrabenazine During Titration and Maintenance in Patients with Tardive Dyskinesia
Authors: Wilhelm Amanda , Anderson Karen E. , Fernandez Hubert H. , Barkay Hadas , Chaijale Nayla , Send Alexander F. , Savola Juha-Matti , Gordon Mark Forrest 
Published: April 2021

AbstractBackgroundDeutetrabenazine is approved to treat tardive dyskinesia (TD) in adults and is titrated weekly by 6 mg/day, from 12 to 48 mg/day, based on dyskinesia control and tolerability. This analysis compared the safety of deutetrabenazine during titration versus maintenance.MethodsSafety was assessed during titration versus maintenance using integrated data from two 12-week placebo-controlled studies (ARM-TD and AIM-TD) and the open-label extension study. Rates were compared for overall and serious adverse events (AEs), AEs leading to discontinuation, treatment-related AEs, common AEs (≥4%), and specific AEs (parkinsonism, suicidal ideation, akathisia, restlessness).ResultsIn titration versus maintenance, AE rates with placebo (n=130) were: overall, 43.1% vs 25.4%; serious, 4.6% vs 2.3%; leading to discontinuation, 3.1% vs 0; treatment-related, 26.9% vs 10.0%. For placebo, common AEs during titration were somnolence, headache, nausea, fatigue, and dry mouth; none occurred during maintenance. In titration versus maintenance, AE rates in fixed-dose deutetrabenazine 12–36 mg (n=216) were: overall, 33.3–38.9% vs 22.2–29.2%; serious, 2.8–6.9% vs 0–1.4%; leading to discontinuation, 2.8–5.6% vs 0; treatment-related, 8.3–16.7% vs 8.3–13.9%. For fixed-dose deutetrabenazine, common AEs during titration were headache, diarrhea, nasopharyngitis, depression, hypertension, and dry mouth; headache was the only common AE during maintenance. In titration versus maintenance, AE rates with flexible-dose deutetrabenazine (n=168) were: overall, 49.4% vs 32.7%; serious, 3.6% vs 2.4%; leading to discontinuation, 2.4% vs 0.6%. For flexible-dose deutetrabenazine, the only common AE during titration was somnolence; none occurred during maintenance. Rates of parkinsonism, suicidal ideation, akathisia, and restlessness were low and comparable in titration and maintenance.ConclusionsDeutetrabenazine was well-tolerated, with AE rates similar to placebo during both phases; AE rates were higher during titration and decreased during maintenance.FundingTeva Pharmaceutical Industries Ltd., Petach Tikva, Israel
Statistical predictors of psychosocial impairment in body-focused repetitive behaviors
Authors: Grant Jon E. , Aslan Ibrahim H. , Chamberlain Samuel R. 
Published: April 2021

AbstractBackgroundSkin picking disorder and trichotillomania, also characterized as body-focused repetitive behaviors (BFRBs), often lead to functional impairment. Some people with BFRBs, however, report little if any psychosocial dysfunction. There has been limited research as to which clinical aspects of BFRBs are associated with varying degrees of functional impairment.MethodsAdults (n = 98), ages 18 to 65 with a current diagnosis of trichotillomania (n = 37), skin picking disorder (n = 32), trichotillomania plus skin picking disorder (n = 10), and controls (n = 19) were enrolled. Partial least squares regression (PLS) was used to identify variables associated with impairment on the Sheehan Disability Scale.ResultsPLS identified an optimal model accounting for 45.8% of variation in disability. Disability was significantly related to (in order of descending coefficient size): severity of picking, perceived stress, comorbid disorders (specifically, anxiety disorders / obsessive–compulsive disorder), trait impulsivity, family history of alcohol use disorder, atypical pulling/picking sites, and older age.ConclusionsAt present mental disorders are viewed as unitary entities; however, the extent of impairment varies markedly across patients with BFRBs. These data suggest that whereas symptom nature/severity is important in determining impairment, so too are other variables commonly unmeasured in clinical practice. Outcomes for patients may thus be maximized by rigorously addressing comorbid disorders; as well as integrating components designed to enhance top-down control and stress management. Interestingly, focused picking and emotional pulling were linked to worse disability, hinting at some differences between the two types of BFRBs, in terms of determinants of impairment.
The Politics of Pandemics: The Effect of Stay-At-Home Orders on COVID-19 Mitigation
Authors: Patterson Shawn 
Published: April 2021

AbstractThe COVID-19 pandemic has upended every aspect of American life. State governments responded quickly to protect public health and stabilize overwhelmed hospital systems. The most restrictive policy, the stay-at-home order, was seen by public health officials as a cornerstone of successful state mitigation strategies. But like many aspects of contemporary politics, support for these efforts took on a distinctly partisan hue. In this paper, I argue that party politics significantly affected state policy responses to COVID-19, which in turn limited mitigation efforts. To this point, I first demonstrate that Democratic governors were faster and more likely to adopt stay-at-home orders than Republicans. Next, using a synthetic control approach, I show that these orders caused residents to practice greater social distancing. Finally, I find that greater social distancing worked to “flattened the curve” by limiting the growth of COVID-19 cases. Together these findings show how party politics affected state pandemic responses and have important long-term implications as states begin lifting restrictions.