bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear generation of long waves and the reversal of eddy momentum fluxes in a two-layer quasi-geostrophic model
Authors: Hsieh Tsung-Lin , Chang Chiung-Yin , Held Isaac M. , Zurita-Gotor Pablo 
Published: August 2021

AbstractAlthough classical theories of midlatitude momentum fluxes focus on the wave-mean flow interaction, wave-wave interactions may be important for generating long waves. It is shown in this study that this nonlinear generation has implications for eddy momentum fluxes in some regimes. Using a two-layer quasi-geostrophic model of a baroclinic jet on a β-plane, statistically steady states are explored in which the vertically integrated eddy momentum flux is divergent at the center of the jet, rather than convergent as in Earth-like climates. One moves towards this less familiar climate from more Earth-like settings by reducing either β, frictional drag, or the width of the baroclinic zone, or by increasing the upper bound of resolvable wavelengths by lengthening the zonal channel. Even in Earth-like settings, long waves diverge momentum from the jet, but they are too weak to compete with short unstable waves that converge momentum. We argue that long waves are generated by breaking of short unstable waves near their critical latitudes, where long waves converge momentum while diverging momentum at the center of the jet. Quasi-linear models with no wave-wave interaction can qualitatively capture the Earth-like regime but not the regime with momentum flux divergence at the center of the jet, because the nonlinear wave breaking and long wave generation processes are missing. Therefore, a more comprehensive theory of atmospheric eddy momentum fluxes should take into account the nonlinear dynamics of long waves.
Endoscope-Assisted Superior Semicircular Canal Dehiscence Repair: Single Institution Outcomes
Authors: Totten Douglas J. , Smetak Miriam R. , Manzoor Nauman F. , Perkins Elizabeth L. , Cass Nathan D. , Hatton Kelsey , Santapuram Pooja , O’Malley Matthew R. , Haynes David S. , Bennett Marc L. , Rivas Alejandro 
Published: August 2021

Objective: To compare outcomes of endoscope-assisted middle cranial fossa MCF) repair of superior semicircular canal dehiscence (SSCD) compared to microscopic MCF repair. Study design: Retrospective cohort. Setting: Tertiary medical center neurotology practice. Methods: Retrospective chart review and cohort study of patients who underwent surgical repair of SSCD via MCF approach from 2010 to 2019 at our institution. Patients were categorized according to use of endoscope intraoperatively. Pre- and post-operative symptom number was calculated from 8 patient-reported symptoms. Pre- and post-operative changes in symptom number were assessed using paired t-tests. Single-predictor binary logistic regression was used to compare final reported symptoms between cohorts. Linear regression was performed to assess air-bone gap (ABG) changes postoperatively between cohorts. Results: Forty-six patients received surgical management for SSCD. Of these, 27 (59%) were male and 19 (41%) were female. Bilateral SSCD was present in 14 cases (29%), of which 3 underwent surgical management bilaterally, for a total of 49 surgical ears. Surgery was performed on the right ear in 19 cases (39%) and on the left in 30 cases (61%). Forty ears (82%) underwent microscopic repair while 9 (18%) underwent endoscope-assisted repair. Microscopic and endoscope-assisted MCF repair both demonstrated significantly improved symptom number postoperatively ( P < .001 for each). There was no significant difference in change in ABG between the 2 cohorts. On average, patient-reported symptoms and audiometrically-tested hearing improved postoperatively in both groups. Conclusion: While endoscopic-assisted MCF repair has the potential to provide better visualization of medial and downslope defects, repair via this technique yields similar results and is equivalent to MCF repair utilizing the microscope alone.
The Neodevelopmentalist Front and Mercosur under the PT Governments: The Rise and Fall of Multidimensional Regionalism
Authors: Berringer Tatiana 
Published: August 2021

An analysis of the relationship between classes and class fractions and Mercosur under the PT (Workers’ Party) governments suggests that the transition from the open regionalism of the 1990s to the multidimensional regionalism of the 2000s and the crisis of the latter were linked to the overlap between the regional integration mechanisms Unasur and Mercosur and the social base of the neodevelopmentalist front. Multidimensional regionalism went into crisis after 2012, when the country began to suffer the impact of the 2008 financial crisis and changes in international politics and when the political process that culminated in the 2016 coup began. Uma análise da relação entre as classes e frações de classe e o Mercosul dos governos PT sugere que a transição do regionalismo aberto dos anos 1990 para o regionalismo multidimensional dos anos 2000 e a crise deste ultimo estão ligados à imbricação entre os processos de integração regional, Unasur e Mercosur, e a base social da frente neodesenvolvimentista. O regionalismo multidimensional entrou em crise a partir de 2012 quando o país começou a sofrer mais o impacto da crise financeira de 2008 e das transformações na política internacional e iniciou-se o processo político que culminou no golpe de 2016.
Sarcopenia measured with paraspinous muscle using computed tomography for predicting prognosis in elderly pneumonia patients
Authors: Bae Sung Jin , Kim Keon , Yun Seong Jong , Lee Sun Hwa 
Published: August 2021

Background: In the elderly, diagnostic findings of pneumonia are often atypical. Computed tomography was recommended for the diagnosis of pneumonia in elderly patients. Recently, the usage of computed tomography as a screening tool for pneumonia in emergency departments has increased. Sarcopenia is defined as the loss of skeletal muscle mass and strength with aging. In this study, the association between sarcopenia and prognosis measured through computed tomography was evaluated compared to CURB-65. Methods: This study was conducted on patients diagnosed with pneumonia through computed tomography from 1 March 2018 to 31 March 2020. The paraspinous muscle size and attenuation were measured at a level located at the T12 pedicle level on axial computed tomography images. Paraspinous muscle size was presented as paraspinous muscle index. Differences in the prognostic performance among the paraspinous muscle size and attenuation, and CURB-65 were evaluated by the area under the receiver operating characteristic curve. Results: A total of 509 patients were included and 132 patients (25.9%) were admitted to the ICU, and 58 patients (11.4%) died in hospital. Paraspinous muscle index was the significant factor for predicting in-hospital mortality and ICU admission. The area under the receiver operating characteristic value of paraspinous muscle index for prediction of mortality was 0.738 and CURB-65 was 0.707. The area under the receiver operating characteristic of paraspinous muscle index and CURB-65 for predicting ICU admission were 0.766 and 0.704, respectively. Conclusion: As a method of measuring sarcopenia, paraspinous muscle index was superior to CURB-65 in elderly pneumonia patients. The use of computed tomography in predicting prognosis for elderly pneumonia patients will ease the economic burden.
Constantly on the move Chinese engineers’ job-hopping strategies in information technology work
Authors: Wu Tongyu 
Published: August 2021

AbstractThis article examines Chinese immigrant engineers’ navigation in the highly flexible information technology (IT) industry in the United States and their strategies of utilizing the high-velocity labour market to their advantage. Flexible employment has grown both in prevalence and prominence in the study of the American IT industry. What flexibility theorists fail to attend to, however, is the ethnicised demission of the high-velocity labour market in the IT sector. To address this vacancy, the researcher conducted a 13-month ethnography at a leading internet-services firm in the United States and 66 additional interviews with engineers from eight leading tech companies. The ethnographic work showed that inequality that emerged within the tech firms (e.g. ‘bamboo ceilings’) disadvantaged Chinese engineers’ career development. The ‘bamboo ceiling’ stimulated Chinese immigrants to use the high-velocity labour market to normalize their job-hopping practices, in order to circumvent their career disadvantage. To facilitate their job-hopping, Chinese engineers developed university-based networks. This study concludes that, with help of their university network, Chinese immigrants became the most mobile group in the US tech industry, which further preserved the industry’s flexibility.
A Review of Direct Oral Anticoagulants in Patients With Stage 5 or End-Stage Kidney Disease
Authors: Starr Jessica A. , Pinner Nathan A. , Mannis Melanie , Stuart Mary Katherine 
Published: August 2021

Objective: To evaluate the role of oral anticoagulation in patients with stage 5 chronic kidney disease (CKD-5) or end-stage kidney disease (ESKD). Data Sources: A literature search of PubMed (January 2000 to July 1, 2021), the Cochrane Library, and Google Scholar databases (through April 1, 2021) was performed with keywords DOAC (direct-acting oral anticoagulant) OR NOAC or dabigatran OR rivaroxaban OR apixaban OR edoxaban AND end-stage kidney disease combined with atrial fibrillation (AF) or venous thromboembolism (VTE) OR pulmonary embolism OR deep-vein thrombosis. Study Selection and Data Extraction: Case-control, cohort, and randomized controlled trials comparing DOACs to an active control for AF or VTE in patients with CKD-5 or ESKD and reporting outcomes of stroke, recurrent thromboembolism, or major bleeding were included. Data Synthesis: Nine studies were included. Efficacy data supporting routine use of warfarin or DOACs in CKD-5 or ESKD are limited. Rivaroxaban and apixaban may provide enhanced safety compared to warfarin in patients with AF. Data for VTE are limited to 1 retrospective study. Relevance to Patient Care and Clinical Practice: Because of the paucity of rigorous, prospective studies in CKD-5 or ESKD, OACs should not be broadly used in this population. It is clear that data regarding efficacy of DOACs cannot be reliably and safely extrapolated from the non-ESKD population. Therefore, use of OACs in this population should be individualized. Conclusions: If OACs for stroke prevention with AF are deemed necessary, apixaban or rivaroxaban can be considered. DOACs cannot currently be recommended over warfarin in patients with CKD-5 or ESKD and VTE.
Diagnostic sensitivity of vitrectomy and vitreous biopsy for vitritis
Authors: Kumaran Neruban , Tan Shi Zhuan , Neffendorf James E , Robins Julian J , Dell’Aversana Orabona Giancarlo , Williamson Tom H 
Published: August 2021

Purpose: To investigate sensitivity of diagnostic vitrectomy and vitreous biopsy for patients with vitritis of unknown aetiology. Methods: Retrospective analysis of all vitrectomies and vitreous biopsies, performed at St Thomas’ Hospital, London, UK, for vitritis between February 2001 and February 2019. Patients were identified using the VITREOR database and records were reviewed. Patients were categorised as infectious, non-infectious or masquerade based on final diagnosis. Sensitivity of both diagnostic pars plana vitrectomy (PPV) and vitreous cutter biopsy in each category was investigated. Furthermore, data on gender, age, and method of anaesthesia were also collected. Results: In our cohort, 64 patients underwent PPV with a diagnostic sensitivity of 67% (43/64) overall and 60% (18/30), 56% (9/16) and 89% (16/18) for those with infectious, masquerade and non-infectious aetiologies, respectively. In comparison, 96 patients underwent a vitreous cutter biopsy with diagnostic sensitivity of 74% (71/96) overall and 71% (55/77), 67% (4/6) and 92% (12/13) for those with infectious, masquerade and non-infectious aetiologies, respectively. No statistically significant difference in sensitivity was identified between the vitrectomy and vitreous biopsy groups for either aetiology. Patients undergoing vitrectomy were noted to be older ( p = 0.02) and more likely to undergo a general anaesthetic ( p < 0.01). Conclusions: Herein we demonstrate similar diagnostic sensitivity of PPV and vitreous cutter biopsy in patients with vitritis of unknown aetiology.
Systematic review and meta-analysis of clinical outcomes of COVID-19 patients undergoing gastrointestinal endoscopy
Authors: Tan Xiangzhou , Guo Jianping , Chen Zihua , Königsrainer Alfred , Wichmann Dörte 
Published: August 2021

Background: The impact of gastrointestinal endoscopy on COVID-19 infection remains poorly investigated. We herein performed a systematic review and meta-analysis to evaluate the outcomes of COVID-19 in patients undergoing gastrointestinal endoscopy. Method: Ovid Medline, Ovid EMBASE, Ovid the Cochrane Library, and other electronic databases were searched until 30 November 2020 to identify publications with confirmed COVID-19 infection in patients undergoing gastrointestinal endoscopy. The primary outcomes were SARS-CoV-2 transmission, personal protective equipment use, rates of case fatality, complications, and procedural success. Results: A total of 18 articles involving 329 patients were included in this systematic review and meta-analysis. The overall basic reproduction rate is 0.37, while the subgroup results from Asia, Europe, and North America are 0.13, 0.44, and 0.33, respectively. The differences in personal protective equipment use between the positive transmission and non-transmission group are mainly in isolation gowns, N95 or equivalent masks, and goggles or face-shields. The rate of case fatality, complication, and procedural success are 0.17 (95% confidence interval = 0.02–0.38), 0.00 (95% confidence interval = 0.00–0.02), and 0.89 (95% confidence interval = 0.50–1.00), respectively. The fatality rate in Europe was the highest (0.23, 95% confidence interval = 0.04–0.50), which is significantly different from other continents ( p = 0.034). Conclusion: The risk of SARS-CoV-2 transmission within gastrointestinal endoscopy units is considerably low if proper use of personal protective equipment is applied. Similarly, a low fatality and complication rate, as well as a high procedural success rate, indicated that a full recovery of endoscopic units should be considered.
COVID, Its Impact on the Mental Health of Caregivers in Childcare Institutions of South Asian Countries and Their Coping Techniques: Analysis of the Caregivers in Childcare Institutions Using Data from Seven South Asian Countries
Authors: Modi Kiran , Kalra Gurneet , Prasad Leena , Babrakzai Najeebullah 
Published: August 2021

Widely across the globe, COVID has placed massive strain on various parameters of life, including child protection, health, education and economic systems. Apart from these visible threats, this situation has an ongoing devastating impact on the mental health and psychological well-being of people. The word of the law enforces care and support for children with disadvantages, disabilities and vulnerabilities on caregivers, Managers and Staff, managing Alternative Care programmes, but the spirit of such child protection laws also underlines the importance of caring for caregivers, especially in childcare institutions (CCIs). The well-being of the caregivers is the cornerstone of every well-functioning childcare institution and other residential care spaces. This article is designed to document the mental health status of caregivers (residential staff staying with children), in residential care spaces in the COVID times and to determine how the new stresses impacted them and the coping patterns they acquired in current situation; across different countries of South Asia, including Afghanistan, Bangladesh, India, Maldives, Nepal, Pakistan and Sri Lanka. This exploratory rapid assessment project aimed to reach out to the registered childcare homes/ institutions, across the South Asian region, with the help of different NGOs, as well as Government mechanisms. The data was collected through purposive sampling and analysed quantitatively where the sample included the selected caregivers of participating CCIs across these nations. This study aimed to synthesize the responses of caregivers across the region; develop an analysis, which may help authorities to rethink, reform and strengthen the current practices, in order to develop approach-centred strategies for improving the well-being of caregivers as this has a direct bearing on the well-being of children in their care. Since the start of the COVID pandemic, for the residential caregivers, the access to external resources, including physical support from professional staff, has become restricted to bare minimum, due to lockdown and quarantine measures. Any interventions to prevent, treat and mitigate the effects of COVID among caregivers needed to be taken at the ground level by the care team management.
Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia
Authors: Stasik Sebastian , Eckardt Jan-Niklas , Kramer Michael , Röllig Christoph , Krämer Alwin , Scholl Sebastian , Hochhaus Andreas , Crysandt Martina , Brümmendorf Tim H. , Naumann Ralph , Steffen Björn , Kunzmann Volker , Einsele Hermann , Schaich Markus , Burchert Andreas , Neubauer Andreas , Schäfer-Eckart Kerstin , Schliemann Christoph , Krause Stefan , Herbst Regina , Hänel Mathias , Frickhofen Norbert , Noppeney Richard , Kaiser Ulrich , Baldus Claudia D. , Kaufmann Martin , Rácil Zdenek , Platzbecker Uwe , Berdel Wolfgang E. , Mayer Jiri , Serve Hubert , Müller-Tidow Carsten , Ehninger Gerhard , Bornhäuser Martin , Schetelig Johannes , Middeke Jan M. , Thiede Christian ,   on behalf of the Study Alliance Leukemia (SAL)
Published: August 2021

Abstract
The tyrosine-protein phosphatase nonreceptor type 11 (PTPN11) is an important regulator of RAS signaling and frequently affected by mutations in patients with acute myeloid leukemia (AML). Despite the relevance for leukemogenesis and as a potential therapeutic target, the prognostic role is controversial. To investigate the prognostic impact of PTPN11 mutations, we analyzed 1529 adult AML patients using next-generation sequencing. PTPN11 mutations were detected in 106 of 1529 (6.93%) patients (median VAF: 24%) in dominant (36%) and subclonal (64%) configuration. Patients with PTPN11 mutations were associated with concomitant mutations in NPM1 (63%), DNMT3A (37%), and NRAS (21%) and had a higher rate of European LeukemiaNet (ELN) favorable cytogenetics (57.8% vs 39.1%; P &lt; .001) and higher white blood cell counts (P = .007) compared with PTPN11 wild-type patients. In a multivariable analysis, PTPN11 mutations were independently associated with poor overall survival (hazard ratio [HR]: 1.75; P &lt; .001), relapse-free survival (HR: 1.52; P = .013), and a lower rate of complete remission (odds ratio: 0.46; P = .008). Importantly, the deleterious effect of PTPN11 mutations was confined predominantly to the ELN favorable-risk group and patients with subclonal PTPN11 mutations (HR: 2.28; P &lt; .001) but not found with dominant PTPN11 mutations (HR: 1.07; P = .775), presumably because of significant differences within the rate and spectrum of associated comutations. In conclusion, our data suggest an overall poor prognostic impact of PTPN11 mutations in AML, which is significantly modified by the underlying cytogenetics and the clonal context in which they occur.
Adaptive Multi-modal Fusion Instance Segmentation for CAEVs in Complex Conditions: Dataset, Framework and Verifications
Authors: Peng Pai , Geng Keke , Yin Guodong , Lu Yanbo , Zhuang Weichao , Liu Shuaipeng 
Published: August 2021

AbstractCurrent works of environmental perception for connected autonomous electrified vehicles (CAEVs) mainly focus on the object detection task in good weather and illumination conditions, they often perform poorly in adverse scenarios and have a vague scene parsing ability. This paper aims to develop an end-to-end sharpening mixture of experts (SMoE) fusion framework to improve the robustness and accuracy of the perception systems for CAEVs in complex illumination and weather conditions. Three original contributions make our work distinctive from the existing relevant literature. The Complex KITTI dataset is introduced which consists of 7481 pairs of modified KITTI RGB images and the generated LiDAR dense depth maps, and this dataset is fine annotated in instance-level with the proposed semi-automatic annotation method. The SMoE fusion approach is devised to adaptively learn the robust kernels from complementary modalities. Comprehensive comparative experiments are implemented, and the results show that the proposed SMoE framework yield significant improvements over the other fusion techniques in adverse environmental conditions. This research proposes a SMoE fusion framework to improve the scene parsing ability of the perception systems for CAEVs in adverse conditions.
Acoustics Based Monitoring and Diagnostics for the Progressive Deterioration of Helical Gearboxes
Authors: Lu Kaibo , Gu James Xi , Fan Hongwei , Sun Xiuquan , Li Bing , Gu Fengshou 
Published: August 2021

AbstractGearbox condition monitoring (CM) plays a significant role in ensuring the operational reliability and efficiency of a wide range of critical industrial systems such as wind turbines and helicopters. Accurate and timely diagnosis of gear faults will improve the maintenance of gearboxes operating under sub-optimal conditions, avoid excessive energy consumption and prevent avoidable damages to systems. This study focuses on developing CM for a multi-stage helical gearbox using airborne sound. Based on signal phase alignments, Modulation Signal Bispectrum (MSB) analysis allows random noise and interrupting events in sound signals to be suppressed greatly and obtains nonlinear modulation features in association with gear dynamics. MSB coherence is evaluated for selecting the reliable bi-spectral peaks for indication of gear deterioration. A run-to-failure test of two industrial gearboxes was tested under various loading conditions. Two omnidirectional microphones were fixed near the gearboxes to sense acoustic information during operation. It has been shown that compared against vibration based CM, acoustics can perceive the responses of vibration in a larger areas and contains more comprehensive and stable information related to gear dynamics variation due to wear. Also, the MSB magnitude peaks at the first three harmonic components of gear mesh and rotation components are demonstrated to be sufficient in characterizing the gradual deterioration of gear transmission. Consequently, the combining of MSB peaks with baseline normalization yields more accurate monitoring trends and diagnostics, allowing the gradual deterioration process and gear wear location to be represented more consistently.