bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMODELAN DINDING CANTILEVER PENAHAN TANAH MENGGUNAKAN SAP 2000 DENGAN MENGANALISA KUAT TEKAN TERHADAP VARIASI BEBAN (STUDI KASUS DI RUAS JALAN BALEROJO KALEGEN)
Authors: Sihombing Jefrizal , I Yoga Satria , Putri Amelia Rosana , Utama Widya 
Published: April 2021

The modeling of retaining wall is adapted to the real conditions on Balerejo Kalegen Street. This wall modeling uses a Cantilever type wall which has a height of 550 cm and a width of 385 cm which is useful for calculating the minimum strength of a cantilever wall for retaining the soil on the Balerejo Kalegen road. In addition, this wall is modeled to have a width of 55 cm, a heel width of 130 cm, a foot width of 130 cm, the width of the next leg is 100 cm, with a wall that enters it is 50 cm and using evenly distributed load variations has been adjusted where the load used is the burden amounting to 11,138, 5.5, 0.3869 tons. When inputting data into SAP 2000 beforehand, calculations must be made related to the force that will affect the wall, then modeling the walls according to the Cantilever shape. After that, Cantilever wall that has been made can be calculated compressive strength and shear strength where the compressive strength of the front wall with an average of 175,154 tons m, the back with an average of 62,666 tons m, the average front heel 866,054 tons m , and the back heel averages 910,463 tons m. Keywords: Cantilever, Retaining Walls, SAP 2000.
Perilaku Retak Pelat Beton Bertulang Akibat Beban Statik
Authors: Agoes Soehardjono, Achfas Zacoeb Fitrayuddin, 
Published: April 2021

Masalah lebar retak merupakan hal yang masih memerlukan penelitian lebih lanjut, kajian riset tentang lebar retak, baik dari teori klasik sampai sekarang masih dibahas dalam sejumlah artikel jurnal. Adapun maksud penelitian ini adalah membuktikan lebar retak komposit pelat dengan variasi tulangan akibat beban statik. Pengujian ini menggunakan pelat dengan ukuran 170x60x20 cm diletakkan diatas tumpuan sederhana. Beban diberikan secara bertahap sampai mencapai retak yang diijinkan (ACI committee 224) sebesar 0,4 mm, benda uji dibuat sebanyak 6 benda uji masing-masing 3D13, 4D13, 5D13, 6D13, 5D16, 6D16. Dari 6 benda uji yang diteliti dapat diuraikan bahwa setelah mencapai retak awal, penambahan beban dilakukan tiap 1 kN agar data yang diperoleh lebih akurat. Kaitannya dengan spasi tulangan, perambatan retak lebih lambat sesuai dengan spasi tulangan pada masing-masing benda uji. Dengan kata lain dapat disimpulkan bahwa semakin banyak tulangan yang dipasang (ρ semakin besar) maka lebar retak maksimum semakin kecil. Berdasarkan grafik hubungan antara tegangan baja dan lebar retak antara eksperimen, peraturan dan peneliti ternyata bahwa pengaruh angka tulangan ρ pada beban statik adalah: 1.Hasil peraturan dan peneliti relatif lebih linier dibandingkan dengan eksperimen. 2. Hasil eksperimen lebih besar dibandingkan dengan hasil peraturan dan peneliti, hasil peraturan lebih kecil dari hasil peneliti. 3. Retak awal pada peraturan dan peneliti lebih cepat dibandingkan dengan hasil eksperimen tetapi perambatan retak eksperimen lebih cepat dari hasil peneliti dan peraturan. Kata-kata kunci: lebar retak, beban statik, tegangan baja.
Pengaruh Implementasi Rencana Tata Ruang Wilayah Terhadap Konservasi Sumber Daya Air Pada Wilayah Studi Kota Batu Jawa Timur
Authors: M.Bisri, Agus Suharyanto Puspa Permanasari, 
Published: April 2021

Penelitian ini bertujuan untuk mengevaluasi penggunaan lahan kondisi eksisting tahun 2010 dengan rencana dalam implementasinya pada Rencana Tata Ruang Wilayah Kota Batu tahun 2003 – 2013 dan menentukan pengaruh penggunaan lahan terhadap konservasi sumber daya air di kota Batu. Metode yang digunakan dalam penelitian ini adalah analisis regresi dan Analisis Proses Heirarki (AHP). Penelitian ini menunjukkan terdapat pengaruh dominan pada penggunaan lahan terhadap konservasi sumber daya air dan mempunyai hasil analis berbeda tiap kecamatan, penurunan nilai infiltrasi terjadi di kecamatan Junrejo sebesar 3 % dan kecamatan Batu sebesar 6%, hal berbeda terjadi di kecamatan Bumiaji, dengan peningkatan nilai infiltrasi sebesar 9%. Secara keseluruhan, besaran daya resap air hujan Kota Batu mengalami peningkatan sebesar 34.587.662 m³/tahun atau 15,9%, disebabkan peningkatan besaran curah hujan dan berhasilnya program penghijauan. Peningkatan infiltrasi di Kota Batu merupakan pengaruh dari peningkatan daya resap air hujan di kecamatan Bumiaji yang meningkat sebesar 46.065.437 m³/tahun atau 31,7%, dengan kontribusi sebesar 76% terhadap total infiltrasi di Kota Batu. Kata-kata kunci: konservasi, penggunaan lahan, infiltrasi
Pengaruh Penggunaan Alat Bantu Pasang Spesi (ALPI) Pada Pemasangan Dinding Bata Merah Sistem ½ Batu
Authors: Trijanto Djoko 
Published: April 2021

Makalah ini menyajikan hasil penelitian yang bertujuan untuk meningkatkan kecepatan dan efisiensi volume pemakaian adukan spesi/mortar pada pemasangan dinding bata merah sistem ½ batu. Jumlah sampel diambilkan dari hasil praktek mahasiswa jurusan Teknik Sipil Politeknik Negeri Malang sebanyak 20 mahasiswa yang terbagi 10 orang memakai ALPI dan 10 orang tanpa menggunakan ALPI. Hasil penelitian menunjukkan adanya peningkatan kecepatan 1,45 kali dan efisiensi volume spesi sebesar 29,9 %. Hasil ini menunjukkan bahwa dengan penggunaan ALPI berpengaruh besar terhadap kecepatan dan efisiensi volume pemakaian adukan spesi pada pemasangan dinding bata merah sistem ½ batu. Kata-kata kunci: spesi,kecepatan, efisiensi, ALPI
PENYUSUNAN PROJECT PLANNING PERBAIKAN TANAH LUNAK DENGAN PREFABRICATED VERTICAL DRAIN (STUDI KASUS PADA AREA LONG BEACH PAKUWON CITY-SURABAYA)
Authors: Amin Fahmi Muhammad 
Published: April 2021

The improvement project was carried out within 30 work days with the project price of IDR 551.439.500,-. In the project management a project planning is in need a carry out the project on time at precise cost and quality. The data needed in this arrangement of project planning were contract documents, list of work force cost, equipment and materials used. Work scheduling and cost arrangement for the project was done with benefit of Microsoft Project Program. The writer discusses the determination of project site layout, traffic management, implementation method, project time schedule, project cost planning, project quality management planning as well as K3 program planning. From the calculating result, the writer summed that the total cost was Rp. 270.950.000.-. When this sum compared to the previous project cost planning was Rp. 551.439.500,- we can difference as much as Rp. 280.489.500.-. In order to assure the working quality, material testing was conducted in laboratory so that the material mounted matched the technical qualifications as well as the use if correct implementation method. To avoid work accident, every worker must use the Self Protection Device and work carefully by the correct working procedures. Keywords: Vertical Drain, Soft Clay, Project Planning
ANALISA FINANSIAL PROYEK PEMBANGUNAN JALAN TOL AA DI JAWA TIMUR
Authors: Kusuma, Marjono, Fauziah S.C.S Maisarah Adham Indra 
Published: April 2021

One attempt to create a good transport system is the construction of new roads toll roads. A toll road construction soon to be implemented is AA segment a which is of investment oriented and expected to give profits to the investors. According to the plan, the toll road is 40.5 km long development is divided into 4 sections. Data required to perform financial analysis is the cost of investment, operation and maintenance cost, traffic volume, and the toll rate plans. These data to find the values of the parameters used to calculate the financial analysis include the Net Present Value (NPV), Internal Rate of Return (IRR), Benefit Cost Ratio (BCR), and Payback Period (PP). The financial analysis will use two funding alternatives, alternative I using 100% equity, alternative II using 30% equity and 70% loan. The purpose of this study is to determine the results of the financial analysis of the parameter values of highway construction project feasibility and determine the most influential factors after a sensitivity analysis has been made. Based on the financial analysis the investment cost results in IDR 3,827,698,222,645. The financial analysis NPV parameters alternative I results in IDR 661,439,934,962 and alternative II in IDR 230,334,925,350 which means they are feasible because both NPVs are greater than 0; both the IRR of 14.18% for alternative I and 13.02% for alternative II are greater than Minimum Attractive Rate Of Return (MARR) value of 12.42%; so, they are feasible; the value of BCR of alternative I is of 1.13 and alternative II is of 1.04; so, they are feasible because the value of BCR is greater than 1. While the PP of alternative I in the period of 12.1 years and alternative II in the period of 13.5 years. The sensitivity analysis of alternatives I and II result in the most influential alternative—when construction period experiences ≥ 3 years backwards.Keywords: investment cost, financial analysis, sensitivity analysis.
PENGARUH KEMACETAN DI SIMPANG SABILILLAH TERHADAP IMPLEMENTASI CITRA LALU LINTAS DI SIMPANG PROGRESIF
Authors: Dwi Ratnaningsih, Rudy Ariyanto Supiyono, 
Published: April 2021

Progress of a country in line with the progress of traffic (transport). Fluency in traffic is determined by the smoothness of traffic on the road. Problems often arise on the highway is congestion at the intersection. Neither was signalized intersections and signalized intersections. Problems at the intersection is less accuracy green flame at the intersection with the number of vehicles in a segment. A road with high traffic volume vehicle green flame low while other road traffic volume small green flame length. So in a long queue roads, while other roads are deserted while still green flame. This study aims to minimize the occurrence of conflic at the intersection of green flame. Research will make iterations in the intersection, where a road section which will be nominated densely green flame, the flame of the green according to the volume of traffic on these roads. Each road will be a green flame in accordance with the volume of traffic, without having to change any program there is a change in traffic volume.The degree of saturation of the calculation obtained by ....Keywords: roads, hight traffic, progressive intersection, degree saturation
Levoketoconazole in the Treatment of Patients With Cushing’s Syndrome and Diabetes Mellitus: Results From the SONICS Phase 3 Study
Authors: Pivonello Rosario , Elenkova Atanaska , Fleseriu Maria , Feelders Richard A. , Witek Przemyslaw , Greenman Yona , Geer Eliza B. , Perotti Paola , Saiegh Leonard , Cohen Fredric , Arnaldi Giorgio 
Published: April 2021

BackgroundCushing’s syndrome (CS) is associated with numerous comorbidities, including diabetes mellitus (DM). Levoketoconazole, an orally administered ketoconazole stereoisomer, is in clinical trials for the treatment of CS.MethodsSONICS, a prospective, open-label, phase 3 study in adults with confirmed CS and mean 24-h urinary free cortisol (mUFC) ≥1.5× ULN, included dose-titration, 6-month maintenance, and 6-month extension phases. This subanalysis evaluated the efficacy of levoketoconazole in patients with DM (n = 28) or without DM (n = 49) who entered the maintenance phase. Safety was evaluated in the overall population (N = 94) during the dose-titration and maintenance phases.ResultsNormalization of mUFC at the end of maintenance phase (EoM), without a dose increase during maintenance (SONICS primary endpoint) was observed in 46% of patients with DM (95% CI, 28 to 66%; P = 0.0006 vs null hypothesis of ≤20%) and 33% of patients without DM (95% CI, 20 to 48%; P = 0.0209). At EoM, mean HbA1c decreased from 6.9% at baseline to 6.2% in patients with DM and from 5.5 to 5.3% in patients without DM. Mean fasting blood glucose decreased from 6.85 mmol/L (123.4 mg/dl) to 5.82 mmol/L (104.9 mg/dl) and from 5.11 mmol/L (92.1 mg/dl) to 4.66 mmol/L (84.0 mg/dl) in patients with and without DM, respectively. Adverse events that were more common in patients with DM included nausea (58.3%), vomiting (19.4%), and urinary tract infection (16.7%); none prompted study drug withdrawal.ConclusionsTreatment with levoketoconazole led to sustained normalization of mUFC and improvement in glycemic control that was more pronounced in patients with DM.Clinical Trial Registration(ClinicalTrials.gov), NCT01838551.
Identification of Prognostic Genes in the Tumor Microenvironment of Hepatocellular Carcinoma
Authors: Xiang Shixin , Li Jing , Shen Jing , Zhao Yueshui , Wu Xu , Li Mingxing , Yang Xiao , Kaboli Parham Jabbarzadeh , Du Fukuan , Zheng Yuan , Wen Qinglian , Cho Chi Hin , Yi Tao , Xiao Zhangang 
Published: April 2021

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The efficacy of immunotherapy usually depends on the interaction of immunomodulation in the tumor microenvironment (TME). This study aimed to explore the potential stromal-immune score-based prognostic genes related to immunotherapy in HCC through bioinformatics analysis.Methods: ESTIMATE algorithm was applied to calculate the immune/stromal/Estimate scores and tumor purity of HCC using the Cancer Genome Atlas (TCGA) transcriptome data. Functional enrichment analysis of differentially expressed genes (DEGs) was analyzed by the Database for Annotation, Visualization, and Integrated Discovery database (DAVID). Univariate and multivariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) regression analysis were performed for prognostic gene screening. The expression and prognostic value of these genes were further verified by KM-plotter database and the Human Protein Atlas (HPA) database. The correlation of the selected genes and the immune cell infiltration were analyzed by single sample gene set enrichment analysis (ssGSEA) algorithm and Tumor Immune Estimation Resource (TIMER).Results: Data analysis revealed that higher immune/stromal/Estimate scores were significantly associated with better survival benefits in HCC within 7 years, while the tumor purity showed a reverse trend. DEGs based on both immune and stromal scores primarily affected the cytokine–cytokine receptor interaction signaling pathway. Among the DEGs, three genes (CASKIN1, EMR3, and GBP5) were found most significantly associated with survival. Moreover, the expression levels of CASKIN1, EMR3, and GBP5 genes were significantly correlated with immune/stromal/Estimate scores or tumor purity and multiple immune cell infiltration. Among them, GBP5 genes were highly related to immune infiltration.Conclusion: This study identified three key genes which were related to the TME and had prognostic significance in HCC, which may be promising markers for predicting immunotherapy outcomes.
Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis
Authors: Khan Samer R. , van der Burgh Anna C. , Peeters Robin P. , van Hagen P. Martin , Dalm Virgil A. S. H. , Chaker Layal 
Published: April 2021

BackgroundAn up-to-date overview of determinants of serum immunoglobulins in adults is pivotal for clinical practice and research, but currently lacking. We therefore performed a systematic review and meta-analysis to identify determinants of serum immunoglobulin levels.MethodsEmbase, Web of Science, Medline, Cochrane, and Google Scholar were searched from inception to July 11th, 2019 for articles reporting on determinants of serum immunoglobulin A, G or M (IgA, IgG or IgM) in adult humans. Random and fixed effect models were applied to obtain pooled mean differences (MDs) and 95% confidence intervals (CIs) for the association of age and sex with serum immunoglobulins.ResultsWe retrieved 117 articles reporting on determinants of serum immunoglobulins, of which 28 could be meta-analyzed. Older compared to younger individuals had higher IgA (MD: 0.38; CI: 0.18 – 0.58), but lower IgM levels (MD: -0.40; 95%: -0.66 – -0.14). Men had higher IgA (MD: 0.22; CI: 0.03 – 0.42), but lower IgM levels (MD: -0.21; CI: -0.32 – -0.10) than women. Age and sex did not influence IgG. Caucasian ethnicity was associated with lower IgA, IgG, and IgM. Smoking and corticosteroid use were associated with lower IgG. Positive associations were reported of probiotics with IgG, alcohol with IgA, hypertension with IgA and IgG, and acute psychological stress with IgA, IgG, and IgM.ConclusionsOlder age and male sex are associated with higher IgA, but lower IgM, and urge investigation of age- and sex-specific reference ranges of immunoglobulins. Other identified determinants were ethnicity, diet, lifestyle and cardio-metabolic factors.
Identify the Characteristics of Metabolic Syndrome and Non-obese Phenotype: Data Visualization and a Machine Learning Approach
Authors: Yu Cheng-Sheng , Chang Shy-Shin , Lin Chang-Hsien , Lin Yu-Jiun , Wu Jenny L. , Chen Ray-Jade 
Published: April 2021

Introduction: A third of the world's population is classified as having Metabolic Syndrome (MetS). Traditional diagnostic criteria for MetS are based on three or more of five components. However, the outcomes of patients with different combinations of specific metabolic components are undefined. It is challenging to be discovered and introduce treatment in advance for intervention, since the related research is still insufficient.Methods: This retrospective cohort study attempted to establish a method of visualizing metabolic components by using unsupervised machine learning and treemap technology to discover the relations between predicting factors and different metabolic components. Several supervised machine-learning models were used to explore significant predictors of MetS and to construct a powerful prediction model for preventive medicine.Results: The random forest had the best performance with accuracy and c-statistic of 0.947 and 0.921, respectively, and found that body mass index, glycated hemoglobin, and controlled attenuation parameter (CAP) score were the optimal primary predictors of MetS. In treemap, high triglyceride level plus high fasting blood glucose or large waist circumference group had higher CAP scores (&gt;260) than other groups. Moreover, 32.2% of patients with high CAP scores during 3 years of follow-up had metabolic diseases are observed. This reveals that the CAP score may be used for detecting MetS, especially for the non-obese MetS phenotype.Conclusions: Machine learning and data visualization can illustrate the complicated relationships between metabolic components and potential risk factors for MetS.
Efficacy of Teprenone for Prevention of NSAID-Induced Gastrointestinal Injury: A Systematic Review and Meta-Analysis
Authors: Zhao Chongxiang , Wang Jingwu , Xiao Qiang 
Published: April 2021

Background: The study aimed to conduct a systematic review and meta-analysis comparing the efficacy of teprenone with control or other drugs for reducing the incidence of gastrointestinal (GI) adverse events in patients receiving long-term non-steroidal anti-inflammatory drugs (NSAIDs).Methods: Databases of PubMed, Embase, BioMed Central, CENTRAL, and Google Scholar were searched up to November 10th, 2020 for randomized controlled trials (RCTs) comparing teprenone with control or other drugs. A random-effects model was used for the meta-analysis. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used for assessing the certainty of evidence.Results: Seven RCTs were included. Six compared teprenone with control and one with famotidine. Meta-analysis indicated a statistically significant reduced risk of GI ulcers in patients receiving teprenone as compared to control after 12 weeks/3months (RR 0.37 95% CI 0.17, 0.18 I2 = 0% p = 0.01). Pooled data of three open-label studies indicated statistically significant reduction of GI symptoms in patients on teprenone as compared to control at 6 months and 12 months, but not at 3 months. Comparing teprenone with control, our analysis indicated non-significant but a tendency of better reduction in Modified Lanza Score (MLS) with teprenone. The RCT comparing teprenone to famotidine demonstrated better reduction of MLS with famotidine. The certainty of evidence-based on GRADE was deemed to be low.Conclusion: Low-quality evidence indicates a beneficial role of teprenone in preventing GI injuries in patients receiving long-term NSAIDs. Further high-quality RCTs comparing teprenone with placebo as well as other gastroprotective drugs are needed to strengthen current evidence.
Small Vessel Disease Burden and Outcomes of Mechanical Thrombectomy in Ischemic Stroke: A Systematic Review and Meta-Analysis
Authors: Xu Tao , Wang You , Yuan Jinxian , Chen Yangmei , Luo Haiyan 
Published: April 2021

Background: Cerebral small vessel disease (SVD) is prevalent in the population, especially among elderly individuals. Substantial uncertainties remain about the clinical relevance of SVD with outcomes of mechanical thrombectomy (MT) in acute ischemic stroke (AIS).Objectives: This systematic review and meta-analysis was performed to evaluate the association between SVD and clinical outcomes in patients with AIS undergoing MT.Methods: We systematically searched the Medline, Embase, and Cochrane databases for relevant clinical studies. The exposure of SVD mainly included leukoaraiosis, cerebral microbleeds (CMBs), and lacunes. The pooled OR was used to calculate the association between each subtype of SVD and outcomes of MT. The primary outcome was poor functional outcome, which was defined as a modified Rankin Scale score (mRS) ≥3 at 90 days after MT. The secondary outcomes included mortality at 90 days, in-hospital mortality, intracranial hemorrhage (ICH) and symptomatic intracranial hemorrhage (sICH), successful recanalization and futile recanalization (FR), early neurological improvement, and early neurological deterioration (END) after MT.Results: Overall, 20 studies with 5,189 patients with AIS undergoing MT were included. High leukoaraiosis burden (HLB) at baseline was associated with increased risks of poor functional outcome at 90 days (OR 2.70, 95% CI 2.01–3.63; p &lt; 0.001; 10 studies; n = 2,004), in-hospital mortality (OR 4.06, 95% CI 1.48–11.13; p = 0.006; 2 studies; n = 314), FR (OR 5.00, 95% CI 2.86–8.73; p &lt; 0.001; 3 studies; n = 493), and END (OR 2.65, 95% CI 1.09–6.45; 1 study; n = 273) after MT. HLB (VSS 3–4 or FS ≥ 2) at baseline was not associated with mortality at 90 days, ICH, or sICH after MT. CMBs at baseline were found to be associated with increased risks of poor functional outcome at 90 days (OR 1.84, 95% CI 1.17–2.90; p = 0.008; 2 studies; n = 1,924) after MT. We found no association between the presence of lacunes and poor functional outcome at 90 days after MT.Conclusions: In patients with AIS undergoing MT, HLB and CMBs were associated with increased risks of unfavorable outcomes after MT.