bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of US Healthcare Personnel Attitudes Towards Coronavirus Disease 2019 (COVID-19) Vaccination in a Large University Healthcare System
Authors: Shaw Jana , Stewart Telisa , Anderson Kathryn B , Hanley Samantha , Thomas Stephen J , Salmon Daniel A , Morley Christopher 
Published: January 2021

Abstract

Background
As a priority group, healthcare personnel (HCP) will be key to the success of coronavirus disease 2019 (COVID-19) vaccination programs. This study assessed HCP willingness to get vaccinated and identified specific concerns that would undermine vaccination efforts.

Methods
We conducted a cross-sectional survey of HCP, including clinical and nonclinical staff, researchers, and trainees, between 23 November and 5 December 2020. The survey evaluated attitudes, beliefs, and willingness to get vaccinated.

Results
There were 5287 respondents with a mean (SD) age of 42.5 (13.56) years; 72.8% were female (n = 3842). Overall, 57.5 % of individuals expressed intent to receive COVID-19 vaccine; 80.4% were physicians and scientists representing the largest group. 33.6% of registered nurses, 31.6% of allied health professionals, and 32% of master’s level clinicians were unsure they would take the vaccine (P &lt; .001). Respondents who were older, male, White, or Asian were more likely to get vaccinated than other groups. Vaccine safety, potential adverse events, efficacy, and speed of vaccine development dominated concerns listed by participants. Fewer (54.0%) providers of direct care versus non–care providers (62.4%) and 52.0% of those who had provided care for COVID-19 patients (vs 60.6% of those who had not) indicated they would take the vaccine if offered (P &lt; .001).

Conclusions
We observed that self-reported willingness to receive vaccination against COVID-19 differs by hospital roles, with physicians and research scientists showing the highest acceptance. These findings highlight important heterogeneity in personal attitudes among HCPs around COVID-19 vaccines and highlight a need for tailored communication strategies.
Building pan-genome infrastructures for crop plants and their use in association genetics
Authors: Jayakodi Murukarthick , Schreiber Mona , Stein Nils , Mascher Martin 
Published: January 2021

AbstractPan-genomic studies aim at representing the entire sequence diversity within a species to provide useful resources for evolutionary studies, functional genomics and breeding of cultivated plants. Cost reductions in high-throughput sequencing and advances in sequence assembly algorithms have made it possible to create multiple reference genomes along with a catalogue of all forms of genetic variations in plant species with large and complex or polyploid genomes. In this review, we summarize the current approaches to building pan-genomes as an in silico representation of plant sequence diversity and outline relevant methods for their effective utilization in linking structural with phenotypic variation. We propose as future research avenues (i) transcriptomic and epigenomic studies across multiple reference genomes and (ii) the development of user-friendly and feature-rich pan-genome browsers.
Morbidity and mortality of lung resection candidates defined by the American College of Chest Physicians as ‘moderate risk’: an analysis from the European Society of Thoracic Surgeons database
Authors: Gooseman Michael Richard , Falcoz Pierre-Emmanuel , Decaluwe Herbert , Szanto Zalan , Brunelli Alessandro 
Published: January 2021

Abstract

OBJECTIVES
The American College of Chest Physicians functional guidelines classify patients with predicted postoperative forced expiratory volume in 1 s or predicted postoperative carbon monoxide lung diffusion capacity &lt;60% and with maximal oxygen consumption (VO2max) between 10 and 20 ml/kg/min in a heterogeneous category broadly defined as ‘moderate risk’ with variable morbidity and mortality. Data to support this statement are lacking. Using the European Society of Thoracic Surgeons database, our goal was to test this definition by evaluating the morbidity and mortality of those patients falling into this class.

METHODS
All patients who had anatomical lung resection for lung cancer (2007–2019) and were deemed of moderate risk were identified in the European Society of Thoracic Surgeons database. Cardiopulmonary morbidity and 30-day mortality of these patients were assessed by the type of operation.

RESULTS
A total 2016 patients were identified. The incidence of cardiopulmonary complications in this group was 21% after lobectomy (294/1435), 29% after bilobectomy (33/112), 22% after pneumonectomy (72/333) and 16% after segmentectomy (22/136) (analysis of variance P = 0.07). The 30-day mortality was 3.4% after lobectomy (49/1435), 8.9% after bilobectomy (10/112), 7.8% after pneumonectomy (26/333) and 3.7% after segmentectomy (5/136) (analysis of variance P = 0.0005). The 30-day mortality rate was 1.6-fold higher in patients with a VO2max between 10 and 15 ml/kg/min compared to those with a higher VO2max [49/861 (5.7%) vs 41/1155 (3.5%); P = 0.022]. For operations that were less extensive than a pneumonectomy and were performed by minimally invasive surgery, there was no difference in mortality between patients with a VO2max between 10 and 15 ml/kg/min and those with a higher VO2max [7/181 (3.8%) vs 11/272 (4.0%); P = 0.92]. On the other hand, after open surgery, the mortality of patients with a lower VO2max (10–15 ml/kg/min) was higher than that of those with a higher VO2max [26/501 (5.1%) vs 20/721 (2.8%); P = 0.034]. Linear regression adjusting for the extent and access of the operation confirmed that within the moderate-risk group a VO2max &lt;15 ml/kg/min was associated with higher mortality (P = 0.028; odds ratio 1.61; 95% confidence interval 1.1–2.5).

CONCLUSIONS
Morbidity and mortality rates found in this study are not negligible and reinforce the recommendation to ensure careful patient discussion and informed decision-making prior to lung cancer resection surgery.
Age-related tilt test responses in patients with suspected reflex syncope
Authors: Rivasi Giulia , Torabi Parisa , Secco Gianmarco , Ungar Andrea , Sutton Richard , Brignole Michele , Fedorowski Artur 
Published: January 2021

Abstract

Aims
Tilt testing (TT) is recognized to be a valuable contribution to the diagnosis and the pathophysiology of vasovagal syncope (VVS). This study aimed to assess the influence of age on TT responses by examination of a large patient cohort.

Methods and results
Retrospective data from three experienced European Syncope Units were merged to include 5236 patients investigated for suspected VVS by the Italian TT protocol. Tilt testing-positivity rates and haemodynamics were analysed across age-decade subgroups. Of 5236 investigated patients, 3129 (60%) had a positive TT. Cardioinhibitory responses accounted for 16.5% of positive tests and were more common in younger patients, decreasing from the age of 50–59 years. Vasodepressor (VD) responses accounted for 24.4% of positive tests and prevailed in older patients, starting from the age of 50–59. Mixed responses (59.1% of cases) declined slightly with increasing age. Overall, TT positivity showed a similar age-related trend (P = 0.0001) and was significantly related to baseline systolic blood pressure (P &lt; 0.001). Tilt testing was positive during passive phase in 18% and during nitroglycerine (TNG)-potentiated phase in 82% of cases. Positivity rate of passive phase declined with age (P = 0.001), whereas positivity rate during TNG remained quite stable. The prevalence of cardioinhibitory and VD responses was similar during passive and TNG-potentiated TT, when age-adjusted.

Conclusions
Age significantly impacts the haemodynamic pattern of TT responses, starting from the age of 50. Conversely, TT phase—passive or TNG-potentiated—does not significantly influence the type of response, when age-adjusted. Vagal hyperactivity dominates in younger patients, older patients show tendency to vasodepression.
A hybrid approach to complex arrhythmias
Authors: Maesen Bart , Luermans Justin G L M , Bidar Elham , Chaldoupi Sevasti-Maria , Gelsomino Sandro , Maessen Jos G , Pison Laurent , Meir Mark La 
Published: January 2021

Abstract
Despite many years of research, the different aspects of the mechanism of atrial fibrillation (AF) are still incompletely understood. And although the latest guidelines recommend catheter ablation with pulmonary vein isolation as a rhythm control strategy, long-term results in persistent and long-standing persistent AF are suboptimal. Historically, a mechanistic-based patient-tailored approach for the treatment of AF was impossible because of the lack real-time mapping techniques and advanced ablation tools. Therefore, surgeons created lesion sets based upon the anatomy of both atria and the safety of the incisions made by the knife. These complex open-heart procedures had to be performed through a sternotomy on the arrested heart and where therefore not generally adopted. The use of controlled energy sources such as cryothermy and radiofrequency where the first step to make the creation of these lesions less complex. With the development and improvement of electrophysiology techniques and catheters, this invasive and solely anatomical approach could again be partially redesigned. Now less invasive, it prepared the way for collaboration between electrophysiologists working on the endocardial side of the heart and cardiac surgeons providing epicardial access. The introduction of video-assisted technology and hybrid procedures has further increased the possibilities of new successful therapies. Now more than 40 years since the beginning of this exciting maze of AF procedures and still working towards a less aggressive and more comprehensive approach we give an overview of the history of the different minimally invasive surgical solutions and of the hybrid approach.
Potential Recolonization Benefits of Retention Forestry Practices
Authors: Loehle Craig , Solarik Kevin A , Greene Daniel U , Six Laura , Sleep Darren J H 
Published: January 2021

AbstractTree retention after forest harvest is often used to enhance biodiversity in forests that are otherwise managed using even-aged systems. It remains unclear to what extent scattered trees and residual patches (i.e., retained structures) actually facilitate recolonization of species in logged areas. For assessing recolonization benefits, it is necessary to consider both survival in retained structures postharvest and recolonization in cleared areas. We conducted a literature review to assess recolonization responses of birds, mammals, reptiles, amphibians, vascular plants, invertebrates, lichens/bryophytes, and mycorrhizal fungi. The clearest benefits of retention were for poorly dispersing plants. Seed dispersal type may be a key life-history trait relative to effectiveness of recolonization, with animal-dispersed seeds having the greatest dispersal range. We found that lichens/bryophytes are likely not dispersal limited (with possible exceptions) but are slow growing and require the development of moist microsite conditions. Significant literature gaps exist for amphibians, nonvolant invertebrates, and mycorrhizal fungi. Overall, recolonization success postharvest is taxon specific, where the benefits of implementing retention systems will depend on the region and species within that region. Species that require a long growth period (some lichens) or are poor dispersers (some herbaceous species) may benefit more from the creation of forest reserves than from retention practices.
Application of multi-trait Bayesian decision theory for parental genomic selection
Authors: Villar-Hernández Bartolo de Jesús , Pérez-Elizalde Sergio , Martini Johannes W R , Toledo Fernando , Perez-Rodriguez P , Krause Margaret , García-Calvillo Irma Delia , Covarrubias-Pazaran Giovanny , Crossa José 
Published: January 2021

AbstractIn all breeding programs, the decision about which individuals to select and intermate to form the next selection cycle is crucial. The improvement of genetic stocks requires considering multiple traits simultaneously, given that economic value and net genetic merits depend on many traits; therefore, with the advance of computational and statistical tools and genomic selection (GS), researchers are focusing on multi-trait selection. Selection of the best individuals is difficult, especially in traits that are antagonistically correlated, where improvement in one trait might imply a reduction in other(s). There are approaches that facilitate multi-trait selection, and recently a Bayesian decision theory (BDT) has been proposed. Parental selection using BDT has the potential to be effective in multi-trait selection given that it summarizes all relevant quantitative genetic concepts such as heritability, response to selection and the structure of dependence between traits (correlation). In this study, we applied BDT to provide a treatment for the complexity of multi-trait parental selection using three multivariate loss functions (LF), Kullback–Leibler (KL), Energy Score, and Multivariate Asymmetric Loss (MALF), to select the best-performing parents for the next breeding cycle in two extensive real wheat data sets. Results show that the high ranking lines in genomic estimated breeding value (GEBV) for certain traits did not always have low values for the posterior expected loss (PEL). For both data sets, the KL LF gave similar importance to all traits including grain yield. In contrast, the Energy Score and MALF gave a better performance in three of four traits that were different than grain yield. The BDT approach should help breeders to decide based not only on the GEBV per se of the parent to be selected, but also on the level of uncertainty according to the Bayesian paradigm.
A data mining approach for improved interpretation of ERT inverted sections using the DBSCAN clustering algorithm
Authors: Sabor Kawtar , Jougnot Damien , Guerin Roger , Steck Barthélémy , Henault Jean-Marie , Apffel Louis , Vautrin Denis 
Published: January 2021

SUMMARY
Geophysical imaging using the inversion procedure is a powerful tool for the exploration of the Earth's subsurface. However, the interpretation of inverted images can sometimes be difficult, due to the inherent limitations of existing inversion algorithms, which produce smoothed sections. In order to improve and automate the processing and interpretation of inverted geophysical models, we propose an approach inspired from data mining. We selected an algorithm known as DBSCAN (Density-Based Spatial Clustering of Applications with Noise) to perform clustering of inverted geophysical sections. The methodology relies on the automatic sorting and clustering of data. DBSCAN detects clusters in the inverted electrical resistivity values, with no prior knowledge of the number of clusters. This algorithm has the advantage of being defined by only two parameters: the neighbourhood of a point in the data space, and the minimum number of data points in this neighbourhood. We propose an objective procedure for the determination of these two parameters. The proof of concept described here is applied to simulated ERT (electrical resistivity tomography) sections, for the following three cases: two layers with a step, two layers with a rebound, and two layers with an anomaly embedded in the upper layer. To validate this approach, sensitivity studies were carried out on both of the above parameters, as well as to assess the influence of noise on the algorithm's performance. Finally, this methodology was tested on real field data. DBSCAN detects clusters in the inverted electrical resistivity models, and the former are then associated with various types of earth materials, thus allowing the structure of the prospected area to be determined. The proposed data-mining algorithm is shown to be effective, and to improve the interpretation of the inverted ERT sections. This new approach has considerable potential, as it can be applied to any geophysical data represented in the form of sections or maps.
Upper crustal shear wave velocity and radial anisotropy beneath Jeju Island volcanoes from ambient noise tomography
Authors: Lee Sang-Jun , Kim Seongryong , Rhie Junkee , Kang Tae-Seob , Kim YoungHee 
Published: January 2021

SUMMARYJeju Island offshore of the southern Korean Peninsula is an isolated intraplate volcano formed by multiple basaltic eruptions from the Pleistocene (∼1.8 Ma) to the Holocene (∼3.7 ka). Due to the lack of available seismic data, magma structures at upper crustal depths of the island have not been clearly revealed. In this study, we imaged upper crustal isotropic and radial anisotropic structures beneath the island using ambient noise data from a temporary seismic network. A series of transdimensional hierarchical Bayesian inversions were performed to construct upper crustal (1–10 km) isotropic and anisotropic structures. Surface wave (Rayleigh and Love wave) group and phase velocity dispersion data were jointly inverted for 2–15 s. The results show that layers of negative anisotropy (VSH &lt; VSV) are predominant at shallower (&lt;2 km) and deeper (&gt;5 km) depths, which was interpreted as reflecting dyke swarms responsible for the more than 400 cinder cones at the surface and the vertical plumbing systems supplying magma from deeper sources, respectively. Additionally, a layer with significantly positive radial anisotropy (VSH &gt; VSV, up to 5 per cent) was found at middle depths (2–5 km), and was interpreted as horizontally aligned magma plumbing systems (e.g. sills) through comparisons with several other volcanoes worldwide. In comparison with the isotropic structure, the positive anisotropic layer was separated into upper and lower layers with locally neutral to slightly fast and slower shear wave velocities, respectively, beneath the largest central crater (Mt Halla). Such a structure indicates that the cooled upper part of the magma plumbing systems formed within the horizontally developed sill complex, and is underlain by still-warm sill structures, potentially with a small fraction of melting. With dykes predominant above and below, the island-wide sill layer and locally high-temperature body at the centre explain the evolution of the Jeju Island volcanoes by island-forming surface lava flows and central volcanic eruptions before and after the eruptions of cinder cones.
Prevalence and factors associated with use of sleeping pills among older adults in Brazil
Authors: Seixas Brayan V 
Published: January 2021

AbstractObjectivesLittle is known about sleeping pills consumption among older adults in low- and middle-income countries. This study investigated the prevalence and factors associated with sleeping pills use among Brazilians aged 50 and over.MethodsA cross-sectional study was conducted using baseline data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil), a nationally representative study of persons aged 50 years and older (n = 9412). Univariate and bivariate analyses were used to describe the sample. Robust Poisson regression was employed to estimate prevalence ratios and predict probabilities.Key findingsPrevalence of sleeping pills use among older Brazilians was estimated at 16.8%, with considerable disparities related to gender (22.3% among women and 10.3% among men), race/skin colour (19.7% among whites and 11.9% among blacks) and geographic region (ranging from 5.9% in the North to 20.5% in the South). The multivariate analysis showed associations between sleeping pills consumption and sociodemographic factors (age, gender, race/skin colour, geographic region and income), health status/behaviour characteristics (poor self-rated health status, number of chronic conditions and alcohol consumption) and variables related to healthcare utilisation (number of visits, usual source of care, care coordination, doctor’s awareness of all medication, difficulty in managing own medication and number of medicines).ConclusionsOur work found that sleeping pills consumption is disproportionately prevalent among women, is associated with worse health status and increases with more medical office visits and use of additional medicines. Moreover, the large inexplicable variations in care deserve special attention from policy-makers and clinicians.
High burden of infections caused by ESBL-producing MDR Escherichia coli in paediatric patients, Yangon, Myanmar
Authors: San Thida , Moe Ingyin , Ashley Elizabeth A , San Nilar 
Published: January 2021

Abstract

Background
There is mounting evidence of a high burden of antimicrobial-resistant infections in children in low- and middle-income countries (LMICs).

Objectives
To detect the frequency of ESBL-producing Escherichia coli in clinical specimens from paediatric patients attending Yangon Children’s Hospital in Myanmar.

Methods
All children attending Yangon Children’s Hospital who had clinical specimens submitted to the hospital diagnostic microbiology laboratory from June 2019 to December 2019 were included in the study. Specimens were processed routinely using standard methods with BD Phoenix used for pathogen identification and susceptibility testing. Presence of ESBLs was determined using the cephalosporin/clavulanate combination disc method with confirmation by PCR.

Results
From 3462 specimens submitted to the Microbiology Laboratory, a total of 123 E. coli were isolated. Among them, 100 isolates were phenotypically ESBL producers, 94 (76.4%) of which were confirmed by PCR [82/94 (87%) CTX-M, 72/94 (77%) TEM, 1/94 (1%) SHV]. Most of the ESBL-producing E. coli were isolated from urine samples (52.1%, 49/94) and the majority were from the surgical unit (61.7%, 58/94). Only 34/94 (36%) isolates were susceptible to meropenem.

Conclusions
This study confirms a high proportion of infections caused by ESBL-producing and MDR E. coli in children hospitalized in Yangon, where access to effective second-line antimicrobials is limited.
Selective Determination of Entecavir in the Presence of its Oxidative Degradate by Spectrophotometric and Chromatographic Methods
Authors: El-Sayed Heba M , Abdel Fattah Laila E , Abdellatef Hisham E , Hegazy Maha A , Abd El-Aziz Mai M 
Published: January 2021

Abstract

Background
Entecavir (ENT) is an antiretroviral agent prescribed for the treatment of the hepatitis B virus(HBV) and human immunodeficiency virus(HIV).

Objective
Development and validation of three simple, sensitive, selective, and precise methods for determination of ENT in the presence of its oxidative degradation product (ENT deg.).

Method
The first method was based on second derivative (D2) spectrophotometry through measuring the peak amplitude of D2 spectra at 293.6 nm. The second one is mean centering of the ratio spectra (MCR), which enabled measurement of the peak amplitude at 280.0 nm. The third method was HPLC, where ENT was separated from ENT deg. using a Zobrax C18 column and methanol:water (30:70, v/v) with pH 3 as a mobile phase. The three developed methods were validated according to the International Conference on Harmonization guidelines.

Results
Linearity range of ENT was 5.00–50.00 μg/mL for both D2 and MCR. However, higher sensitivity was achieved using HPLC (1.00–50.00 μg/mL). Accuracy of ENT were 100.60 ± 0.547%, 101.55 ± 1.2071%, and 100.61 ± 1.207% for D2, MCR, and HPLC methods, respectively, and precision was within 1.280.

Conclusions
The developed methods were successfully applied for the determination of ENT in Tecavir® tablets without interference from ENT deg. They showed no significant difference in comparison with the official method and they can be applied in the quality analysis of ENT with high selectivity, accuracy, and precision.

Highlights
ENT was quantified using two spectrophotometric (D2 and MCR) methods and an HPLC method in presence of ENT deg. The proposed methods were applied to analysis of ENT tablets with high selectivity, sensitivity, and accuracy.