bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efecto protector de la vacuna estacional inactivada trivalente para uso en 2008-2009, contra virus pandémico A/H1N1
Authors: Hernández-Collazo A , Cuéllar-Garrido E , Rivera. Barragán V 
Published: March 2021

De abril a junio de 2009, se reportaron casos confirmados de influenza por un nuevo virus A/H1N1, que obligaron a la OMS a elevar el nivel de alerta de pandemia de fase 3 a fase 6. Se conoce la vacunación como medida clave en la prevención; sin embargo, se obtuvieron pocos datos que evalúan la eficacia de la vacuna estacional 2008-2009 contra la nueva cepa pandémica. Objetivo: Evaluar la asociación de la vacuna estacional trivalente 2008-9 de virus inactivados con los casos de influenza del Hospital General ISSSTE Aguascalientes, durante la epidemia en México. Material y métodos: 24 pacientes con influenza A/H1N1 confirmada por laboratorio y 55 controles con resultado negativo (neumonía no influenza) ingresados a nuestro Hospital. Aplicando la prueba estadística Ji cuadrada para valorar efectividad de vacuna trivalente. Resultados: El grupo sin antecedente de vacunación se encontró con mayor probabilidad de admisión hospitalaria debido a diagnóstico confirmado de neumonía por influenza A/H1N1 que aquellos con el antecedente con una diferencia estadísticamente significativa (p < .05). Conclusiones: La evidencia preeliminar sugiere cierta protección de la vacuna trivalente inactivada 2008-2009 contra la influenza pandémica A/H1N1, en especial en formas severas diagnosticada durante la epidemia de influenza 2009.
Enfermedad Trofoblástica Gestacional
Authors: Hernández-Gallo P D , García- Aguilar J R , Galaviz de Anda J M 
Published: March 2021

Resumen: La enfermedad trofoblástica gestacional (ETG), es un grupo de patologías con una característica común, la de la proliferación anormal del tejido del trofoblasto, con el crecimiento desorganizado del tejido acompañada o no de embrión o feto. Es el excesivo aporte paterno del genoma, en la mola, lo que se considera importante en la génesis tumoral. La inmunohistoquímica ha permitido conocer mejor la biología del trofoblasto lo que viene a constatar que la célula citotrofoblástica presenta una gran capacidad de proliferación. La mola hidatidiforme parcial o total afecta a aproximadamente 1 de cada 500 a 1.000 embarazos. El diagnóstico definitivo se hace con estudios histológicos y cariotipo tras el legrado. El diagnóstico se basa en la anamnesis, en la exploración general y ginecológica, en la ecografía y en la determinación de β HCG. La resolución de la mola será la interrupción del embarazo se debe de realizar vaciamiento uterino tan pronto se establezca el diagnóstico.
Catéteres con reservorio para uso prolongado
Authors: González-Fisher R F , Montiel-Mendoza Z I , Marín-Magallanes C 
Published: March 2021

La instalación de catéteres de silicón con reservorio subcutáneo para uso prolongado han mejorado sustancialmente la calidad de vida de los pacientes sometidos a quimioterapia antineoplásica, tratamiento antibiótico prolongado, nutrición parenteral total o aquellos que requieren de tomas frecuentes de sangre para estudios de laboratorio, sin embargo, su uso no está libre de complicaciones, presentamos la experiencia de un grupo quirúrgico con 100 catéteres en 98 pacientes con seguimiento mínimo de 6 meses, y discutimos las complicaciones encontradas y posibles formas de evitarlas
Trasplante ortotópico hepático en poliquistosis hepática
Authors: Alvarado-Murillo Ramón Fernando , Flores-Álvarez Efrén 
Published: March 2021

La poliquistosis hepática o enfermedad quística del hígado se define como la presencia de más de 20 quistes hepáticos, tiene un carácter autosómico dominante y predomina en el género femenino en una relación 4:1 Tiene una prevalencia del 2% al 7.8% en la población general. Se presenta el caso clínico de una paciente de 56 años con poliquistosis hepática difusa, la cual se sometió a trasplante hepático ortotópico como manejo definitivo. Se decidió realizar laparotomía exploradora para hepatectomía total con trasplante hepático ortotópico con técnica preservadora de la vena cava del receptor (piggyback technique), extrayendo una pieza quirúrgica con un peso neto de 7,890 gr. No se presentaron complicaciones perioperatorias. El seguimiento a los cuatro meses es favorable, con tratamiento a base de inhibidor de calcineurina y prednisona, con pruebas de funcionamiento hepático normal. LUX MÉDICA AÑO 8, NÚMERO 23, ENERO-ABRIL 2013, PP 39-46
Gated SPECT Myocardial Perfusion Imaging in female patients - an observational study
Authors: Sarker Azmal K , Naznin Afroza , Sultana Nasreen , Nasreen Faria , Nisa Lutfun 
Published: March 2021

Background: It had been a general observation that the number of female patients undergoing SPECT myocardial perfusion imaging (MPI) is lower per week.This study was done to find out their proportionand association among their symptoms, history of (h/o) acute coronary syndrome (ACS) and corresponding myocardial perfusion.
Patients and methods:This cross sectional retrospective study was conducted in 2017 on a group of patients who underwent gated SPECT myocardial perfusion imaging (GSMPI)from February 2005 to October 2016. Clinical record files and image files of all female patients were selected for analysis. The symptoms were retrospectively categorized according to New York Heart Association (NYHA) class while the patients were categorized according to their h/o ACS and myocardial perfusion in each patient was categorized as normal or perfusion defect. Data were analyzed using SPSS v.20.
Results:Among 1347 patients undergoing GSMPI 196 (14.6%) were female with a 4.4-fold increase in number over 12 years. Mean age was 51.8 ± 10.1 (27-80). Symptom categorization assigned 84 patients in NYHA class I and 112 in NYHA class II. There was no h/o ACS in 143 while 53 had a previous h/o hospitalization due to ACS. GSMPI revealed normal perfusion in 156 patients with mean left ventricular ejection fraction (LVEF) of 66.6 ± 13.6. Perfusion defect was present in 40 patients with mean LVEF of 45.5 ± 15.8. NYHA class of symptoms was not associated with perfusion status (p > 0.05).H/o ACS was found to have association both with NYHA class of symptoms and with perfusions status (p < 0.05).
Conclusions: Proportion of female patients undergoing GSMPI is low. Presence of perfusion defect in female was not associated with NYHA class of symptom.
Bangladesh J. Nuclear Med. 22(2): 103-107, Jul 2019
Pelvic Kidney Mimicking Skeletal Metastasis on Bone Scan- Interesting Image
Authors: Bhuiyan Mohammed Mehedi Al Zahid , Sarker Azmal Kabir , Choi Hongyoon , Suh Minseok , Cheon Gi Jeong 
Published: March 2021

A 57-year-old female patient underwent left breast-conserving surgery with sentinel lymph node biopsy for Left breast carcinoma (stage IIA). The patient had hypertension and diabetes mellitus. Other findings include multiple hepatic cyst, bilateral renal cysts and uterine myoma. She had no significant renal symptoms and her liver &renal function test were normal.She was sent for Technetium-99m-methylene diphosphonate (99mTc-MDP) bone scan. There was a large area of intense tracer concentration in the region of right sacro-iliac (SI) joint which appeared like an osteoblastic metastasis at first glance. However, absence of uptake in the right renal fossa with the left kidney being normal in position contemplated the probability of right-sidedpelvickidneywhich was confirmed later by a contrast enhanced computerized tomography (CT) scan of abdomen that showed a pelvic right kidney overlying the sacrum.
Bangladesh J. Nuclear Med. 22(2): 155-156, Jul 2019
SISTEM PENGOLAHAN DATA JEMAAT GKJ KISMOREJO BERBASIS WEB
Authors: Aji Setiawan Oktavianus Bima , WINARSIH S.M SANTI 
Published: March 2021

The problems faced by GKJ Kismorejo currently are still using Microsoft Office Word and in disseminating information such as data on congregations that are still active or not active, information on congregations who died, congregational marriages, and other congregational data through paper-based congregations. To print church messages and reports requires a large amount of operational funds. In addition, data collection and storage still have shortcomings, including recording some data in books, difficulties in processing large amounts of data and storing it in only one place. For this reason, the authors raise the background of the problems that occur, the authors are interested in conducting research with the title Designing Data Processing Systems for Web-Based GKJ Kismorejo Congregation. The purpose of this research is to design and produce a data processing system for the church. Using this system can facilitate data processing in the church.
Keywords: web, data processing, operational
Permasalahan yang dihadapi GKJ Kismorejo saat ini masih menggunakan Microsoft Office Word dan dalam penyebaran informasi seperti data jemaat yang masih aktif atau sudah tidak aktif, informasi jemaat meninggal dunia, pernikahaan jemaat, dan data jemaat lainnya melalui warta jemaat yang berbasis kertas. Untuk mencetak warta jemaat dan laporan membutuhkan dana operasional cukup besar. Selain itu pengumpulan dan penyimpanan data masih terdapat kekurangan di antaranya mencatat beberapa data pada buku, kesulitan untuk mengolah data dalam jumlah besar dan tersimpan hanya pada satu tempat. Untuk itu penulis mengangkat latar belakang dari permasalahan yang terjadi, penulis tertarik untuk melakukan penelitian dengan judul Perancangan Sistem Pengolahan Data Kegiatan Jemaat GKJ Kismorejo Berbasis Web. Tujuan penelitian ini untuk merancang dan menghasilkan suatu sistem pengolahan data untuk gereja. Dengan menggunakan sistem ini dapat memudahkan dalam pengolahan data dalam gereja.
Kata kunci : web, pengolahan data,operasional
Cord Lining Mesenchymal Stem Cells Have a Modest Positive Effect on Angiogenesis in Hindlimb Ischemia
Authors: Chua Kenon , Lim Fui Ping , Lee Victor Kwan Min , Phan Toan Thang , Tai Bee Choo , Tan Yih Kai 
Published: March 2021

Purpose: We investigated the use of human Cord Lining Mesenchymal Stem Cells (CL-MSCs) (US Patent number 9,737,568), in a rabbit hindlimb ischemia model, and evaluated their potential in stimulating neovascularization. Allogenic human CL- MSCs could potentially be used to treat patients with lower limb ischemia and non-healing wounds.Methods: Twenty rabbits were divided into two separate groups. We created a hindlimb ischemia model surgically. At 21 and 49 days post-operatively, animals in the treatment group were injected with CL-MSCs (500,000 cells per 0.2 ml on each site) at 10 different sites (Quadriceps- 4 sites, Hamstrings- 4 sites and Calf-−2 sites) in the hindlimb muscles. The control group received only saline injection to the corresponding sites at the same time point as the treatment group. We then evaluated the effects of treatment on neovascularization by angiography, laser doppler perfusion imaging, as well as by histology. We evaluated the tissue samples for any signs of local immune reaction to the cell implantation. We also observed the rabbit clinically for any adverse effects after treatment.Results: We found a higher number of CD31 positive cells in the treatment group, with a greater number of capillaries found in the treated muscles. The Rectus Femoris demonstrated a median vessel count/muscle fiber of 0.121 for the treatment group, compared to 0.076 in the control group (median difference 0.04; 95% CI 0.001–0.11; p = 0.041). The Gastrocnemius demonstrated a median vessel count/muscle fiber of 0.175 for the treatment group, compared to 0.089 in the control group (median difference 0.087; 95% CI −0.006 to 0.234; p = 0.07). Blood perfusion quantification through Laser Doppler Perfusion Imaging (LDPI) also demonstrated a non-statistically significant increase in perfusion in favor of the treatment group. CL-MSCs demonstrated no toxicity associated morbidity and minimal local immune reaction to implantation.Conclusion: CL-MSCs have a positive effect on angiogenesis in a rabbit hindlimb ischemia model. This preliminary data is encouraging and paves the way for future large animal studies or for clinical trials.
Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
Authors: Liu Shan-Kui , Hao Haifang , Bian Yuan , Ge Yong-Xi , Lu Shengyuan , Xie Hong-Xu , Wang Kai-Ming , Tao Hongrui , Yuan Chao , Zhang Juan , Zhang Jie , Jiang Cheng-Shi , Zhu Kongkai 
Published: March 2021

α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and promote glucose conversion, which have been used for the treatment of type 2 diabetes. In the present study, 52 candidates of α-glycosidase inhibitors were selected from commercial Specs compound library based on molecular docking–based virtual screening. Four different scaffold compounds (7, 22, 37, and 44) were identified as α-glycosidase inhibitors with IC50 values ranging from 9.99 to 35.19 μM. All these four compounds exerted better inhibitory activities than the positive control (1-deoxynojirimycin, IC50 = 52.02 μM). The fluorescence quenching study and kinetic analysis revealed that all these compounds directly bind to α-glycosidase and belonged to the noncompetitive α-glycosidase inhibitors. Then, the binding modes of these four compounds were carefully investigated. Significantly, these four compounds showed nontoxicity (IC50 &gt; 100 μM) toward the human normal hepatocyte cell line (LO2), which indicated the potential of developing into novel candidates for type 2 diabetes treatment.
Meta-Analysis: Association Between Hypoglycemia and Serious Adverse Events in Older Patients Treated With Glucose-Lowering Agents
Authors: Mattishent Katharina , Loke Yoon K. 
Published: March 2021

AimsWe conducted a meta-analysis of serious adverse events (dementia, macro- and micro-vascular events, falls and fractures, and death) associated with hypoglycemia in older patients treated with glucose lowering drugs.Materials and MethodsMeta-analysis of studies reporting on hypoglycemia and adverse events. The search included studies from two previously published systematic reviews, and an updated search of MEDLINE and EMBASE from April 2014 to November 2019. We assessed study validity based on ascertainment of hypoglycemia, adverse events and adjustment for confounders, and conducted a random effects meta-analyses, assessing heterogeneity using the I2 statistic.ResultsWe included 44 studies involving 2,507,434 participants. Most of the studies used adjusted analysis for confounders and hypoglycaemic events were typically identified based on healthcare databases (severe events). Hypoglycemia was associated with increased likelihood of death in a meta-analysis of eighteen studies, pooled OR 2.02 (95% Confidence Interval 1.75–2.32). Studies assessing mortality signal a time-response relationship with a higher risk of adverse events occurring within the first 90 days after hypoglycemia. Our meta-analysis of nine studies demonstrated that hypoglycaemic episodes were associated with dementia – pooled OR 1.50 (95% CI 1.29–1.74). Our meta-analysis of nineteen studies demonstrated associations between hypoglycaemia and macrovascular complications, pooled OR 1.81 (95% CI 1.70–1.94), and microvascular complications (two studies) pooled OR 1.77 (95% CI 1.49–2.10). There is also an association between hypoglycemia and cardiovascular death (six studies) – pooled OR 2.11 (95% CI 1.55 to 2.87). Similarly, our meta-analysis of six studies demonstrated an association between hypoglycemia and falls and fractures, pooled OR 1.78 (95% CI 1.44–2.21) and 1.68 (95% CI 1.37–2.07) respectively.ConclusionThis meta-analysis confirms previously reported concerns of serious harm following hypoglycemia, especially in the immediate time period after a hypoglycaemic event. Avoidance of hypoglycaemic episodes should be a priority in this vulnerable population.
Beyond Alkaloids: Novel Bioactive Natural Products From Lobelia Species
Authors: Zheng Qinfang , Wang Ye , Zhang Shuihan 
Published: March 2021

In this work, we reviewed the progress in the phytochemical and biological investigations of bioactive components derived from medicinally valuable Lobelia species. In the last 60 years, Lobelia has garnered significant attention from the phytochemist from around the world, majorly due to the discovery of bioactive piperidine alkaloids (e.g., lobinaline and lobeline) in the early 1950s. Later, lobeline underwent clinical trials for several indications including the treatment of attention deficit hyperactivity disorder and a multicenter phase three trial for smoking cessation. Subsequently, several other alkaloids derived from different species of Lobelia were also investigated for their pharmacological characteristics. However, in the last few years, the research focus has started shifting to the characterization of the other novel chemical classes. The major shift has been noticed due to the structurally similar alkaloid components, which essentially share similar pharmacological, physicochemical, and toxicological profiles. In this review, we present an up-to-date overview of their progress with special attention to understanding the molecular mechanisms of the novel bioactive components.
Seasonal variation in ground water quality in and around Integrated Industrial Estate (IIE) Haridwar, India
Authors: Khanna D.R. , Bhutiani R. , Kulkarni Dipali Bhaskar 
Published: March 2021

A total of eighteen groundwater sources were sampled over a year to study physico-chemical properties and heavy metal content of ground water in and around the integrated industrial estate of Haridwar. Study area included locations with in approximately 5 kms around the industrial area. Samples taken were representative of different land uses including the ecosensitive zone of Rajaji National park. Ground water quality in the study area exceeds permissible standard limits for conductivity, hardness, alkalinity, nitrate, total solids and total dissolved solids at some locations. Total alkalinity in the study area was found to be maximum in summer (574.67 mg/l) at the Railway station area and minimum (85.33 mg/l) in rainy season. Nitrate levels were found to be maximum in winter (1291.61 mg/l) at the rural area. Chloride level in the study area was found to range from a minimum (12.67 mg/l) in summer to a maximum (169.33 mg/l) in winter. Highest sulphate level (192.67 mg/l) was recorded at the rural area. Chromium and iron levels were found to exceed standard limits at almost all locations in the study area.
Mycological and physico-chemical study of a fish pond in Paniyala in Haridwar district of Uttarakhand
Authors: Khanna D.R. , Rana Rajni , Ishaq Fouzia 
Published: March 2021

Water is essential to life, but many people do not have access to clean and safe drinking water and many die of waterborne microbial infections. Mycological studies and physico-chemical parameters are an important criterion for evaluating the suitability of water for various purposes. In this study, we tried to assess the fungal species richness and physico-chemical status of fish pond in Paniyala in Haridwar district of Uttarakhand to predict the state of this pond. A total of four species were recorded which include Aspergillus flavus, Candida albicans, Penicillium Spp. and Fusarium Spp. Present study revealed that among fungal species, Aspergillus flavus was reported with higher in number 7.44±3.45 (ml-1x103) and Fusarium Spp.was recorded with minimum number of 5.15±2.06 (ml-1x103). The total species diversity was higher in the month of April (39.80 ml1x103. The water samples were also analyzed for physico-chemical parameters like temperature, pH, conductivity, DO, BOD, Free CO2, calcium and magnesium. Higher value of temperature, pH, BOD, Free CO2 and lower values of dissolved oxygen concentration were recorded and the results revealed deteriorated water quality. The fungal population showed positive significant correlation with physico-chemical parameters like, temperature, pH, biological oxygen demand, calcium and magnesium whereas negatively correlated with conductivity and dissolved oxygen.
First record of Longnose marbled whipray Fluvitrygon oxyrhyncha (Sauvage, 1878) (Myliobatiformes: Dasyatidae) in Malaysian waters
Authors: Hasan Veryl , Gausmann Peter , Nafisyah Ayu Lana , Isroni Wahyu , Widodo Maheno Sri , Islam Izzul , Anggih Chaidir Riri Rimbun 
Published: March 2021

An individual of Longnose marbled whipray Fluvitrygon oxyrhyncha (Sauvage, 1878) (60 cm of total length) was caught and photographed on 3 August 2020, from Pahang River, Kuala Lipis District, Pahang, Malaysia. This rare finding represents the first-ever known record of F. oxyrhyncha in Malaysian waters, and only the fourth record in Southeast Asia besides former records of F. oxyrhyncha from Thailand, Cambodia, and Indonesia. Further study and monitoring is needed to asses the possibility of the importance of Pahang River as habitat of F. oxyrhyncha.
Analysis of the primary presenting symptoms and hematological findings of COVID-19 patients in Bangladesh
Authors: Mohiuddin Chowdhury Abu Taiub Mohammed , Karim Md Rezaul , Mehedi HM Hamidullah , Shahbaz Mohammad , Chowdhury Md Wazed , Dan Guo , He Shuixiang 
Published: March 2021

Introduction: SARS-Cov-2 infection or COVID-19 is a global pandemic. In this manuscript, we investigated the primary symptoms and basic hematological presentations of SARS-CoV-2 infection among the Bangladeshi patients.
Methodology: This was a multicentre cross-sectional study done on COVID-19 patients tested positive by RT PCR in Bangladesh. Clinical features of mild to moderate degree of COVID-19 patients; hematological and biochemical admission day laboratory findings of moderate to severe degree hospitalized COVID-19 patients were analyzed.
Results: COVID-19 patients in Bangladesh commonly presented with fever, cough, fatigue, shortness of breath, and sore throat. But symptoms like myalgia, diarrhea, skin rash, headache, Abdominal pain/cramp, nausea, vomiting, restlessness, and a higher temperature of >100°F have a greater presentation rate and more frequent than other published studies. CRP and Prothrombin time was found to increase in all the patients. Serum ferritin, ESR, SGPT, and D-Dimer were increased among 53.85%, 80.43, 44%, and 25% patients. 17.39% of the patients had leucocytosis and neutrophilia, 28.26% presented with lymphocytopenia, and 62.52% had mild erythrocytopenia. The difference between the decrease hemoglobin count (higher in the male) and increased SGPT (higher in female) against gender was significant.
Conclusions: Our study had evaluated a different expression in presenting symptoms of COVID-19 patients in Bangladesh. CRP, Prothrombin time, serum ferritin, ESR, SGPT, D-Dimer, erythrocytopenia, and lymphocytopenia can be assessments for diagnosis and prognosis of COVID-19 disease. Decrease hemoglobin count (higher in the male) and increased SGPT (higher in female) establish these two markers as a good candidate for diagnostic value against gender.