bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual and collective stop-based adaptive trajectory segmentation
Authors: Bonavita Agnese , Guidotti Riccardo , Nanni Mirco 
Published: October 2021

AbstractIdentifying the portions of trajectory data where movement ends and a significant stop starts is a basic, yet fundamental task that can affect the quality of any mobility analytics process. Most of the many existing solutions adopted by researchers and practitioners are simply based on fixed spatial and temporal thresholds stating when the moving object remained still for a significant amount of time, yet such thresholds remain as static parameters for the user to guess. In this work we study the trajectory segmentation from a multi-granularity perspective, looking for a better understanding of the problem and for an automatic, user-adaptive and essentially parameter-free solution that flexibly adjusts the segmentation criteria to the specific user under study and to the geographical areas they traverse. Experiments over real data, and comparison against simple and state-of-the-art competitors show that the flexibility of the proposed methods has a positive impact on results.
Neighbourhood cohesion and territorial cohesion: in search for conceptual integrity
Authors: Damurski Łukasz 
Published: October 2021

AbstractNeighbourhood cohesion is a concept describing the residents’ sense of community, engagement in acts of neighbouring, and attractiveness of living in the neighbourhood. Since 2000’s the term ‘cohesion’ has also been used in geography and in spatial policy to represent the distribution of functions and opportunities in space. The two approaches seem be complementary, but they lack consistency and appropriate conceptual framework. This paper aims at developing an integrated methodological framework which will include both social and spatial aspects of cohesion at the local level. Its empirical content refers to studies conducted in 2017–2019 in five locations in Poland. Three methods of spatial analysis are presented depicting various aspects of territorial cohesion of a neighbourhood: functional balance, accessibility of facilities and match between supply and demand. Such approach enables effective measurement and comparison of neighbourhoods representing various settlement types. The results show that the highest levels of cohesion were obtained for large cities where the density of amenities is the highest, and the lowest levels were noted in suburban settlements which confirms their malfunctioning character. The paper concludes with a critical revision of the concept of neighbourhood cohesion which can serve as a guideline for local urban policy.
Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid
Authors: Sabbah Hani N. 
Published: October 2021

AbstractBarth syndrome is a rare and potentially fatal X-linked disease characterized by cardiomyopathy, skeletal muscle weakness, growth delays, and cyclic neutropenia. Patients with Barth syndrome are prone to high risk of mortality in infancy and the development of cardiomyopathy with severe weakening of the immune system. Elamipretide is a water-soluble, aromatic-cationic, mitochondria-targeting tetrapeptide that readily penetrates and transiently localizes to the inner mitochondrial membrane. Therapy with elamipretide facilitates cell health by improving energy production and inhibiting excessive formation of reactive oxygen species, thus alleviating oxidative stress. Elamipretide crosses the outer membrane of the mitochondrion and becomes associated with cardiolipin, a constituent phospholipid of the inner membrane. Elamipretide improves mitochondrial bioenergetics and morphology rapidly in induced pluripotent stem cells from patients with Barth syndrome and other genetically related diseases characterized by pediatric cardiomyopathy. Data with elamipretide across multiple models of disease are especially promising, with results from several studies supporting the use of elamipretide as potential therapy for patients with Barth syndrome, particularly where there is a confirmed diagnosis of cardiomyopathy. This review highlights the challenges and opportunities presented in treating Barth syndrome cardiomyopathy patients with elamipretide and addresses evidence supporting the durability of effect of elamipretide as a therapeutic agent for Barth syndrome, especially its likely durable effects on progression of cardiomyopathy following the cessation of drug treatment and the capability of elamipretide to structurally reverse remodel the failing left ventricle at the global, cellular, and molecular level in a gradual manner through specific targeting of the mitochondrial inner membrane.
Context Modulates Attention to Faces in Dynamic Social Scenes in Children and Adults with Autism Spectrum Disorder
Authors: Kaliukhovich Dzmitry A. , Manyakov Nikolay V. , Bangerter Abigail , Pandina Gahan 
Published: October 2021

AbstractIndividuals with autism spectrum disorder (ASD) have been found to view social scenes differently compared to typically developing (TD) peers, but results can vary depending on context and age. We used eye-tracking in children and adults (age 6–63) to assess allocation of visual attention in a dynamic social orientation paradigm previously used only in younger children. The ASD group (n = 94) looked less at the actor’s face compared to TD (n = 38) when they were engaged in activity (mean percentage of looking time, ASD = 30.7% vs TD = 34.9%; Cohen’s d = 0.56; p value < 0.03) or looking at a moving toy (24.5% vs 33.2%; d = 0.65; p value < 0.001). Findings indicate that there are qualitative differences in allocation of visual attention to social stimuli across ages in ASD.ClinicalTrials.gov identifier: NCT02668991.
Liberation of eicosapentaenoic acid and degradation of the major cell wall polysaccharide porphyran by fermentation of nori, the dried thalli of Pyropia yezoensis, with koji
Authors: Hama Yoichiro , Yamagata Emi , Takahama Noriko , Yoshimura Yuka , Yanagida Rin , Mitsutake Susumu 
Published: October 2021

AbstractIn this study, dried sheets of nori, shredded and processed thalli of the red alga Pyropia yezoensis, were fermented with either barley, rice or soybean koji. High-performance liquid chromatographic analyses of the lipid extracts of the fermented products indicated that the fermentation of nori with all kinds of tested koji released free fatty acids, including the eicosapentaenoic acid, from ester lipids. We found that approximately half of the eicosapentaenoic acid in nori had been released as the free fatty acid at up to 4 weeks of fermentation at 30 °C and more than 65% at 8 to12 weeks in the fermented products with barley and rice koji. We also demonstrated the degradation of porphyran, a major cell wall polysaccharide of nori, by gel chromatography on Sephacryl S-300 HR of hot water extracts of the fermented products of nori with barley koji. Approximately two-third of porphyran had been degraded to porphyran oligosaccharides up to 6 weeks of fermentation. Fermentation of nori with koji may bring out the potential health-promoting functions of nori.
Family Alliance in Infancy and Toddlerhood Predicts Social Cognition in Adolescence
Authors: Tissot Hervé , Lapalus Noémie , Frascarolo France , Despland Jean-Nicolas , Favez Nicolas 
Published: October 2021

AbstractInfants developing in a cooperative family alliance (FA), characterized by cohesion and mutual support between family members observable during mother–father–child interactions, will likely experience more affect sharing and empathy early in life. Previous studies showed that these experiences might have a positive impact on the development of social cognition, as the development of FA from 3 to 18 months was shown to predict theory of mind (ToM) competences at age 4.5. This study aimed to extend these results to adolescence, as we hypothesized that higher FA in the postpartum would be linked better social cognition skills at age 15 years. We assessed FA during mother–father–child interactions at 3, 9, and 18 months postpartum (N = 49) and adolescents’ social cognition skills in a computerized emotion recognition task at age 15 years. Results of growth curve models showed that the stable, but not the changing, components of FA from 3 to 18 months, predicted better emotion recognition—particularly for positive emotional expressions—at age 15 years, when controlling for ToM at age 4.5 years. Results are discussed in light of prior research on the links between early family relationships and children’s development from early childhood to adolescence.
Design of a Security and Trust Framework for 5G Multi-domain Scenarios
Authors: Jorquera Valero José María , Sánchez Sánchez Pedro Miguel , Lekidis Alexios , Fernandez Hidalgo Javier , Gil Pérez Manuel , Siddiqui M. Shuaib , Huertas Celdrán Alberto , Martínez Pérez Gregorio 
Published: October 2021

AbstractWith the expansion of 5G networks, new business models are arising where multi-tenancy and active infrastructure sharing will be key enablers for them. With these new opportunities, new security risks are appearing in the form of a complex and evolving threat landscape for 5G networks, being one of the main challenges for the 5G mass rollout. In 5G-enabled scenarios, adversaries can exploit vulnerabilities associated with resource sharing to perform lateral movements targeting other tenant resources, as well as to disturb the 5G services offered or even the infrastructure resources. Moreover, existing security and trust models are not adequate to react to the dynamicity of the 5G infrastructure threats nor to the multi-tenancy security risks. Hence, we propose in this work a new security and trust framework for 5G multi-domain scenarios. To motivate its application, we detail a threat model covering multi-tenant scenarios in an underlying 5G network infrastructure. We also propose different ways to mitigate these threats by increasing the security and trust levels using network security monitoring, threat investigation, and end-to-end trust establishments. The framework is applied in a realistic use case of the H2020 5GZORRO project, which envisions a multi-tenant environment where domain owners share resources at will. The proposed framework forms a secure environment with zero-touch automation capabilities, minimizing human intervention.
What’s in a Word? Just vs. Fair vs. Appropriate Earnings for Self and Others
Authors: Adriaans Jule , Liebig Stefan , Sabbagh Clara , Jasso Guillermina 
Published: October 2021

AbstractDespite Rawls’ famous call to distinguish between justice and fairness, these and other justice-related words often seem to be used interchangeably by both ordinary people and justice researchers. Based on a survey-embedded question wording experiment (N = 4534) fielded in Germany as part of the GESIS Panel, we explore the effects of three justice words— “just,” “fair,” and “appropriate”—on the sense of justice about earnings for self and others. We observe differences in the just reward, justice evaluation, and justice consequences by justice word. For example, justice evaluations of one’s own earnings are more negative, i.e., deeper in the underreward territory, signaling larger just rewards, when using “just” instead of “fair” or “appropriate” in the question wording. No such clear pattern emerges for justice evaluations of others’ earnings. Our analyses show the decreasing effect of an underreward situation on psychosocial health to be significantly stronger in the “just” condition compared to the “fair” condition but do not reveal differential consequences by justice word for measures of satisfaction and trust. Overall, the observed differences by justice words are moderate in size. Nonetheless, our findings suggest caution for justice researchers in communicating with peers and respondents and warrant further inquiry extending research on the role of “justice language” to other language–country contexts.
NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s Disease
Authors: Anantha Jayanth , Goulding Susan R. , Tuboly Eszter , O’Mahony Adam G. , Moloney Gerard M. , Lomansey Gareth , McCarthy Cathal M. , Collins Louise M. , Sullivan Aideen M. , O’Keeffe Gerard W. 
Published: October 2021

AbstractParkinson’s disease (PD) is a neurodegenerative disease characterised by the progressive degeneration of midbrain dopaminergic neurons, coupled with the intracellular accumulation of α-synuclein. Axonal degeneration is a central part of the pathology of PD. While the majority of PD cases are sporadic, some are genetic; the G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic form. The application of neurotrophic factors to protect dopaminergic neurons is a proposed experimental therapy. One such neurotrophic factor is growth differentiation factor (GDF)5. GDF5 is a dopaminergic neurotrophic factor that has been shown to upregulate the expression of a protein called nucleoside diphosphate kinase A (NME1). However, whether NME1 is neuroprotective in cell models of axonal degeneration of relevance to PD is unknown. Here we show that treatment with NME1 can promote neurite growth in SH-SY5Y cells, and in cultured dopaminergic neurons treated with the neurotoxin 6-hydroxydopamine (6-OHDA). Similar effects of NME1 were found in SH-SY5Y cells and dopaminergic neurons overexpressing human wild-type α-synuclein, and in stable SH-SY5Y cell lines carrying the G2019S LRRK2 mutation. We found that the effects of NME1 require the RORα/ROR2 receptors. Furthermore, increased NF-κB-dependent transcription was partially required for the neurite growth-promoting effects of NME1. Finally, a combined bioinformatics and biochemical analysis of the mitochondrial oxygen consumption rate revealed that NME1 enhanced mitochondrial function, which is known to be impaired in PD. These data show that recombinant NME1 is worthy of further study as a potential therapeutic agent for axonal protection in PD.
Metta-Based Therapy for Chronic Depression: a Wait List Control Trial
Authors: Stangier Ulrich , Frick Artjom , Thinnes Isabel , Arens Elisabeth A. , Hofmann Stefan G. 
Published: October 2021

Abstract
Objectives
Current treatments for chronic depression have focused on reducing interpersonal problems and negative affect, but paid little attention to promoting prosocial motivation and positive affect. Following this treatment focus, the objective of the present study was to examine whether the combination of metta (Loving Kindness) group meditation and subsequent tailored individual therapy focusing on kindness towards oneself and others (metta-based therapy, MBT) shows greater improvements in depressive symptoms than a wait list control group in patients with chronic depression.

Methods
Forty-eight patients with DSM-5 persistent depressive disorder were randomly assigned to MBT or a wait list control condition. Outcome was assessed after group meditation, after subsequent individual therapy, and at 6-month follow-up. The primary outcome measure was an independent blind rating of depressive symptoms at post-test. Secondary outcome included changes in self-reported depression, behavioral activation, rumination, social functioning, mindfulness, compassion, and clinician-rated emotion regulation.

Results
Mixed-design analyses showed significant differences between MBT and WLC in changes from pre- to post-test in clinician-rated and self-rated depression, behavioral activation, rumination, social functioning, mindfulness, and emotion regulation. Most of the changes occurred during group meditation and were associated with large effect sizes. Improvements were maintained at 6-month follow-up.

Conclusions
The results provide preliminary support for the effectiveness of MBT in treating chronic depression.

Trial Registration
ISRCTN, ISRCTN97264476.
The basic principles of a socially just arts curriculum, and the place of drama
Authors: O’Toole John 
Published: October 2021

AbstractThis paper provides a descriptive historical analysis of the planning and writing of the Australian Curriculum: The Arts which occurred from 2009 to 2013. This process involved extensive consultation across a range of stakeholders, including curriculum research, background reading and analysis that preceded the Australian Curriculum, Assessment and Reporting Authority’s writing process. The curriculum itself was underpinned by a range of democratic principles, including the importance of developing a socially just curriculum. This necessitated extensive discussion which interrogated the terms excellence and equity to ensure a high-quality arts education was accessible for all students, regardless of their background. The implementation of these principles is then explored through the perspective of the Drama writing team, including the importance of the subject Drama in developing a sense of inquiry and empathy in students by exploring their own and others’ stories and points of view. The final curriculum document for the Arts, and specifically for Drama exemplifies the importance of these social justice principles in responding to the Melbourne Declaration on Educational Goals for Young Australians (2008) which advocates for equity and excellence in Australian schooling and for all young Australians to become successful learners, confident and creative individuals and active and informed citizens.
Optimal bounds of classical and non-classical means in terms of Q means
Authors: Nowicka Monika , Witkowski Alfred 
Published: October 2021

AbstractWe show optimal bounds of the form $$Q_\alpha<M<Q_\beta $$

Q
α

<
M
<

Q
β

, where $$\begin{aligned} Q_\alpha (x,y)={\mathsf {A}}(x,y)\frac{{\mathsf {A}}^2(x,y)}{(1-\alpha ){\mathsf {A}}^2(x,y)+\alpha {\mathsf {G}}^2(x,y)} \end{aligned}$$

Q
α

(
x
,
y
)

=
A

(
x
,
y
)

A

2

(
x
,
y
)

(
1
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α
)

A

2

(
x
,
y
)

+
α

G

2

(
x
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)

and M belongs to a broad class of classical homogeneous, symmetric means of two variables.
Phenotypic and genotypic data of a European beech (Fagus sylvatica L.) progeny trial issued from three plots along an elevation gradient in Mont Ventoux, South-Eastern France
Authors: Oddou-Muratorio Sylvie , Gauzere Julie , Angeli Nicolas , Brahic Patrice , Brendel Oliver , De Castro Marie , Gilg Olivier , Hossann Christian , Jean Frédéric , Lingrand Matthieu , Pringarbe Mehdi , Rei Frank , Roig Anne , Thevenet Jean , Turion Norbert 
Published: October 2021

Key Message
We provide phenotypic and genotypic data for a progeny trial of 5813 European beech seedlings, originating from 60 open-pollinated families collected at three altitudes (1020 m; 1140 m, 1340 m) on Mont Ventoux (44° 11′ N; 17° 5′ E).
Fear-Related Reasons for Avoiding Sexual Intercourse in Early Pregnancy: A Cross-Sectional Study
Authors: Phan Thanh C. , Hoang Long B. , Tran Thanh K. , Pham Trang T.T. , Bui Anh V. , Dao Hoa T. , Ngo Toan V. , Tran Cuong D. 
Published: October 2021

Abstract

Introduction
Several studies have reported women's worry that sexual intercourse may harm the course of pregnancy. This worry might lead to avoidance of sexual intercourse during pregnancy.

Aim
To assess if fears about harming the pregnancy are associated with avoidance of sexual intercourse during pregnancy.

Methods
A cross-sectional study was conducted on 250 Vietnamese pregnant women in the first or second trimester who visited our hospital for antenatal care. We explored 5 types of fears including miscarriage/preterm labor, premature rupture of membranes, bleeding, infection, and injury to the fetus. Fears were measured by modified questions from the Reasons For Not Engaging in Sexual Activity During Pregnancy questionnaire. Using the total fear score, pregnant women were categorized into having low, moderate, and high fear.

Main Outcome Measure
Not having sexual intercourse during the past 4 weeks.

Results
72 (28.8%) pregnant women had no sexual intercourse for the past 4 weeks. All types of fear were considered important among pregnant women; the more important fears were infection and injury to the fetus. In multivariable regression analysis, the prevalence of not having sexual intercourse was higher in both women who had moderate (adjusted prevalence ratio = 2.84, 95% CI 1.42–5.67) and high fear (adjusted prevalence ratio = 4.39, 95% CI 2.28–8.44).

Conclusion
Avoidance of sexual intercourse was common among Vietnamese pregnant women and was associated with the fears about harming the pregnancy. This can be a target in the health education programs for pregnancy couples.
The Relationship Between Pelvic Floor Function and Sexual Function in Perimenopausal Women
Authors: Zhuo Zhihong , Wang Chuhan , Yu Huimin , Li Jing 
Published: October 2021

Abstract

Introduction
Perimenopausal women with pelvic floor dysfunction have worse sexual function than women with functional pelvic floor muscle (PFM), especially in terms of libido, orgasm, sexual satisfaction, and total Female Sexual Function Index (FSFI) scores.

Aim
To explore the relationship between pelvic floor muscle function, hormone levels and sexual function in perimenopausal women.

Methods
An analytical cross-sectional study was conducted in 252 women aged 40–55 without pelvic floor disease with FSFI, pelvic floor muscle strength and the hormone levels.

Main Outcome Measure
The principle aim was to determine the relationships between sexual dysfunction, PFM strength, and hormone levels.

Results
In the functional PFM group, the proportion of menopausal hormone therapy was higher. The proportion of overweight in the dysfunctional PFM group was higher, and had more sexual desire disorder, more orgasm disorder, lower sexual satisfaction, and poor FSFI scores. The correlation between PFM strength, sexual function and female sex hormones suggested that PFM strength and libido, sexual satisfaction and FSFI score are significantly positively correlated, while PFM strength and sexual arousal disorder and vaginal lubricity had a positive correlation. In the multivariate analysis of the risk of sexual dysfunction among perimenopausal women, the higher the PFM strength, the lower the risk of sexual dysfunction.

Conclusions
Perimenopausal women with pelvic floor dysfunction have worse sexual function than women with functional PFM, especially in obese women, those with central adiposity, and not using hormone replacement therapy. The PFM strength was weakly positively correlated with sexual arousal, orgasm, sexual satisfaction, and FSFI score.