bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study
Authors: Haar Anne Marleen ter , Vlist Merel M. Nap-van der , Hof Malon Van den , Nijhof Sanne L. , Litsenburg Raphaële R. L. van , Oostrom Kim J. , Pajkrt Dasja 
Published: May 2021

Abstract
Background

Fatigue is common among adults living with human immunodeficiency virus (HIV) as well as children with a chronic disease (CCD). Fatigue can have disastrous effects on health status, including health related quality of life (HRQOL). Even so, fatigue is underexplored in children and adolescents perinatally infected with HIV (PHIV+) in the Netherlands. This study aims to explore fatigue in PHIV + and its association with their HRQOL.
Methods

We measured HRQOL and fatigue using the Pediatric Quality of Life Inventory™ (PedsQL 4.0) and the PedsQL Multidimensional Fatigue Scale (MFS). The PedsQL MFS encompasses three subscales: general fatigue, sleep/rest fatigue and cognitive fatigue, and a total fatigue score. We compared outcomes of PHIV + with three groups: 1) HIV-uninfected controls (HIV-) matched for age, sex, socioeconomic status and adoption status, 2) CCD, and 3) the general Dutch population. Within the PHIV + group we explored associations between fatigue and HRQOL.
Results

We enrolled 14 PHIV+ (median age 10.2 years [IQR 9.2–11.4]) and 14 HIV-. Compared to CCD, PHIV + significantly reported less general fatigue (mean difference 13.0, 95% CI 1.3 to 24.8). PHIV + did not score significantly different on any of the other PedsQL MFS scales compared to HIV-, CCD or the general Dutch population. PHIV children scored relatively low on the cognitive fatigue scale in comparison to HIV-uninfected matched controls, CCD and the general population, although these differences did not reach significance. Among PHIV+, a lower score on total fatigue, sleep/rest fatigue and cognitive fatigue was associated with a lower HRQOL score.
Conclusions

The results of this study suggest that PHIV children and adolescents do not experience more symptoms of fatigue than their healthy peers. However, PHIV children and adolescents may be more likely to experience cognitive fatigue. Fatigue in PHIV also appears to be associated with children’s HRQOL. Further research should confirm these exploratory findings.
A Bayesian Geo-Additive Modeling of Childhood Anemia in India
Authors: Chungkham Holendro Singh , MARBANIANG STRONG P , Narzary Pralip Kumar 
Published: May 2021

Abstract
Background

The geographical differences that caused anaemia can be partially explained by the variability in environmental factors, particularly nutrition and infections. The studies failed to explain the non-linear effect of the continuous covariates on childhood anaemia. The present paper aimed to investigate the risk factors of childhood anaemia in India with focus on geographical spatial effect.
Methods

Geo-additive logistic regression models were fitted to the data to understand fixed as well as spatial effects of childhood anaemia. Logistic regression was fitted for the categorical variable with outcomes (anaemia (Hb < 11) and no anaemia (Hb ≥ 11)). Continuous covariates were modelled by the penalized spline and spatial effects were smoothed by the two-dimensional spline.
Results

At 95% posterior credible interval, the influence of unobserved factors on childhood anaemia is very strong in the Northern and Central part of India. However, most of the states in North Eastern part of India showed negative spatial effects. A U-shape non-linear relationship was observed between childhood anaemia and mother’s age. This indicates that mothers of young and old ages are more likely to have children who are anaemic; in particular mothers aged 15 years to about 25 years. Then the risk of childhood anaemia starts declining after the age of 25 years and it continues till the age of around 37 years, thereafter again starts increasing. Further, the non-linear effects of duration of breastfeeding on childhood anaemia show that the risk of childhood anaemia decreases till 29 months thereafter increases.
Conclusion

Strong evidence of residual spatial effect to childhood anaemia in India. Government child health programme should gear up in treating childhood anaemia by focusing on known measurable factors such as mother’s education, mother’s anaemia status, family wealth status, child fever, stunting, underweight, and wasting which have been found to be significant in this study, attention should also be given to effects of unknown or unmeasured factors to childhood anaemia at the community level. Special attention to these unmeasurable factors should be focused in the states of central and northern India which have shown significant positive spatial effects.
Project DASH: (Divas Against the Spread of HIV/AIDS): Results of a Pilot Study on HIV Risk and Mother-Daughter Communication Among HIV+ Mothers with African American Daughters
Authors: Amutah-Onukagha Ndidiamaka N. , Agbemenu Kafuli , Cederbaum Julie , Fletcher Faith , Abara Winston 
Published: May 2021

Abstract
Background: Daughters of HIV positive women are often exposed to similar factors that placed their mothers at risk of HIV. Compared to women of other racial/ethnic groups, African American women have disproportionately higher rates of HIV/AIDS. This pilot study examines the relationship between African American HIV positive mothers and their daughters, and this relationship’s association with mother-daughter HIV risk communication and related domains.Methods: This mixed-method study employed quantitative surveys and qualitative interviews. All participants completed the quantitative survey while qualitative data were collected from a subset of participants. Results: Ninety-eight percent of respondents were African American, 73% had been HIV-infected for at least 10 years, and the mean age was 49.9 years. Among daughters, 85% reported feeling comfortable talking to their mothers about sex.Discussion: Results underscore the need to strengthen the mother-daughter communication around these topics in ways that may positively influence the sexual behaviors of the daughter.
Large-scale fabrication of SU-8 polymer micro/ nanoscale nozzle by hot embossing and UV exposure
Authors: Guo Ran , Qi Liping , Xu Liang , Yin Zhifu , Zou Helin 
Published: May 2021

Abstract
Electrohydrodynamic-jet printing (E-jet printing) is a direct-writing technology for manufacturing micro-nano devices. In order to further reduce the inner diameter of the nozzle to improve the printing resolution, a large-scale manufacturing method of an SU-8 polymer micro/nanoscale E-jet nozzle chip by means of a process combining inverse ultraviolet (UV) exposure and hot embossing is proposed. First. a convex nano-mold is made by pouring polydimethylsiloxane (PDMS) on the concave 2D silicon nano-mold. The convex patterns so achieved were transferred as nanochannels in a layer of SU-8 that was hot-embossed by the PDMS mold. After removal from the mold, the 188 nm wide and 80 nm deep SU-8 nanochannels were covered with an SU-8 cover layer to become nozzles, to which the microchannel were add by inverse UV photolithography and development. The method of manufacturing SU-8 polymer micro/ nanoscale E-jet nozzle chips developed in this study will greatly promote the study of the transport properties of nanoscale channels in E-jet nozzles, and enable further development of E-jet based applications.
The moment of communicating the diagnosis of neuromuscular diseases: an integrative review
Authors: Fernandes Isabella Araujo Mota , Batista Alex Novais , Melo Letícia Pinheiro , Menezes Renata Oliveira Almeida , Rego Guilhermina 
Published: May 2021

Abstract
Background: The communication of diagnosis of neuromuscular genetic diseases is a very important moment, because if there is a lack of understanding about the disease, it can limit decision-making, compromising freedom and autonomy of the patients, with several repercussions, such as tendency towards more aggressive therapies in detriment of ensuring better quality of life. Methods: The guiding question was: did the moment of communicating the diagnosis of neuromuscular diseases value the ethical principles of beneficence, non-maleficence and autonomy? So it was carried out a integrative review with the search for original research articles in the portals Pubmed, Bireme and Scopus between November 2020 and March 2021, whose descriptors were (“Muscular Diseases" OR "Neuromuscular Diseases") AND "Truth Disclosure".Results: Only one article was found, published in 1983, which had as object of study the diagnosis of Duchenne Muscular Dystrophy. In this study, most patients received the diagnosis without the support of a family member, the time elapsed until the diagnosis was variable, with greater satisfaction for those who had their diagnosis more quickly. Another relevant factor in satisfaction was the scheduling of a return visit to answer questions and discuss the disease management.Conclusions: The present studies deal with clinical observations, screening methods, complementary exams and treatments, but little is discussed about the communication of the diagnosis and how this moment impacts on the lives of the patients. Thus, the ethical principles of non-maleficence, beneficence and autonomy must also be applied when diagnosing these diseases, in order to ensure a better doctor-patient relationship and better follow-up of the disease.
Status małżeństw nieważnych z powodu zaistniałej przeszkody lub braku formy kanonicznej w kanonicznym porządku prawnym (kan. 1107 KPK)
Authors: Dzierżon Ginter 
Published: May 2021

W zaprezentowanym opracowaniu Autor poddał analizie kan. 1107 KPK dotyczącego statusu małżeństw nieważnych z powodu zaistniałej przeszkody lub braku formy kanonicznej w kanonicznym porządku prawnym. Z przeprowadzonych badań wynika, iż jego funkcjonowanie jest wyrazem troski prawodawcy kościelnego o ochronę wymiaru prawnoformalnego węzła małżeńskiego. Wykazał, iż ratio legis tego kanonu jest umożliwienie konwalidacji nieważnego związku z powodu zaistnienia przeszkody zrywającej lub braku formy kanonicznej.
Single Nucleotide Polymorphisms as the Efficient Prognostic Markers in Breast Cancer
Authors: Alimardani Maliheh , Moghbeli Meysam , Rastgar-Moghadam Azam , Shandiz Fatemeh Homaei , Abbaszadegan Mohammad Reza 
Published: May 2021

Background:
Breast cancer (BC) is known as the most common malignancy in women.
Environmental and genetic factors are associated with BC progression. Genetic polymorphisms
have been reported as important risk factors for BC prognosis and drug response.

Main body:
In the present review, we have summarized all of the single nucleotide polymorphisms
(SNPs) which have been significantly associated with drug response in BC patients in the
world. We have also categorized the reported SNPs based on their related gene functions to clarify
the molecular biology of drug responses in BC.

Conclusion:
The majority of SNPs were reported in detoxifying enzymes which introduced such
genes as the main genetic risk factors during BC drug responses. This review paves the way for introducing
a prognostic panel of SNPs for the BC patients in the world.
Digital Eye Strain During COVID-19 Lockdown in Jeddah, Saudi Arabia
Authors: Almarzouki Nawaf , Faisal Konooz , Nassief Arwa , Najem Noura , Eid Rayana , Albakri Renad , Alhibshi Dana , Alwethinani Shehana , Ashi Heba 
Published: May 2021

Objectives: This study aimed to determine the prevalence of computer vision syndrome (CVS) and associated risk factors of prolonged use of electronics.
Methods:
This was an online non-interventional cross-sectional studyconducted over the period of COVID curfew in Jeddah city from April to June 2020, through a questionnaire. Participants were between 20 and 60 years of age and used electronic devices.
Results:
Total 1,227 participants were recruited between 20 and 60 years of age. The majority of them were females (69.9%). Almost 1,048 participants used smartphones or laptops. More than half (54.5%) of them used electronics for more than 4 hours daily. A high symptom severity score was found in 44% of the respondents. Taking breaks during electronics use <30 minutes (P=0.018), viewing computers at a distance less than arm length (P=0.001), and the use of screen protectors (p=0.014) were significant factors related to the symptomâ€™s severity score.
Conclusion:
CVS was prevalent among the participants who used electronics for more than 4 hours daily. Taking breaks during electronics use, viewing computers at an appropriate distance, and the use of screen protectors were effective practices to relieve the eye symptoms severity score.
Oral health of children in association with gender and mothersâ€™ education: a comparative cross-sectional study
Authors: Ashi Heba 
Published: May 2021

Objectives: To evaluate the association between gender and mothers' education, and the oral hygiene of their children.
Methods: This comparative cross-sectional study included 531 children in Jeddah, Saudi Arabia. Arabic was chosen for this survey to avoid possibilities of language barriers, followed by data analysis and segregation from the survey. Students were stratified according to gender and their motherâ€™s education. Data was analyzed using the Statistical Package for the Social Sciences (SPSS), version 25.
Results: Brushing twice daily, using the dental floss, using fluoridated toothpaste, using mouthwash regularly, and bruxism were higher among females than males (58% VS 28%, 28.2% VS 10.9%, 71% VS 30%,55% VS 35% and 16.5% VS 9.8% respectively) with a significant difference (p<0.001, <0.001, <0.001, <0.001 and <0.001 respectively). Meanwhile, using toothpick, clenching, and biting on hard objects were higher among males than females
49.3% VS 34.9%, 21.7% VS 7.1% and 46.7% VS 34.9% respectively) with a significant difference (<0.001 and <0.001, respectively).
Going to dentists during the last three months was significantly higher among females than males (47% vs. 33%), with a significant difference (p<0.001). On the other hand, going to dentists every six months was notably higher among males than females (22% vs. 17%) (p<0.001). Regular check-ups were higher among females (27.8% vs. 16.7%), with a significant difference (p=0.007). In accordance with the mothers' education, brushing more than twice daily, manual toothbrush, electrical toothbrush, dental floss, and using toothpaste were significantly higher among those who received a university and post-graduate education (p<0.001, <0.001, <0.001, and 0.049, respectively). Going to dentists during the previous three and six months was higher among those who received a university and post-graduate education (p=0.001).
Conclusion: Girls and children whose mothers had a university and post-graduate education had better attitudes toward oral hygiene. Therefore, we highly recommend more oral hygiene health education programs, especially for mothers with less education.
EFEITO DE HIPERONÍMIA NO PROCESSAMENTO DA CORREFERÊNCIA INTERFRASAL EM PORTUGUÊS BRASILEIRO
Authors: Teixeira Elisângela Nogueira , Soares Maria Elias 
Published: May 2021

Investigamos as relações de hiperonímia e hiponímia entre antecedente e correferente em posição sintática de sujeito e de objeto. Reportamos dois estudos que analisaram a movimentação ocular de participantes durante a leitura de orações coordenadas em Português Brasileiro. Nossos resultados de tempo total de leitura corroboram estudos prévios que identificaram menor custo de processamento para a relação de hiperonímia.
Supply Chain Management dan Value Chain Analysis Produksi Ampelas
Authors: Hendri Hendri 
Published: May 2021

Penelitian ini bertujuan untuk membuat Supply Chain Management (SCM), mengetahui kondisi internal dan usulan perbaikan industri ampelas. Supply chain adalah mencakup lingkup area bisnis yang terdiri dari pemasok bahan baku,proses serta pengiriman produk ke pelanggan akhir. Sedangkan Value Chain Analysis (VCA) adalah rantai nilai yang dapat mengetahui kekuatan rantai dari aktivitas internal perusahaan. Ampelas adalah berfungsi untuk menghaluskan permukaan benda kerja dengan cara digosok. Metode analisis yang digunakan SCM dan VCA. Hasil penelitian ini diketahui SCM ampelas terdiri dari rantai pasok jumbo roll, converting dan import. Produksi jumbo roll diketahui Inbound Semua perusahaan menggunakan metoda sederhana dan dapat mengunakan sistem Informasi Teknologi (IT). Aktivitas Operations satu perusahaan menggunakan mesin otomatis dan Tiga perusahaan menggunakan mekanisasi yang dapat ditingkatkan menggunakan mesin semi otomatis dan aktivitas Outbound Logistics, satu perusahaan ada jalur distribusi pelayanan sudah seimbang.dan tiga perusahaan belum memiliki jalur distribusi, dapat menggunakan jalur distribusi pelayanan seimbang antara produksi dan distribusi.
PENERAPAN METODE PRAKTIKUM VIRTUAL BERBASIS SIMULASI PHET BERBANTUAN GUIDED-INQUIRY MODULE UNTUK MENINGKATKAN PENGETAHUAN KONTEN FISIKA
Authors: Defianti Aprina , Hamdani Dedy , Syarkowi Ahmad 
Published: May 2021

AbstrakPenelitian ini bertujuan untuk mengetahui peningkatan pengetahuan konten fisika melalui penerapan metode praktikum virtual berbasis simulasi PhET berbantuan Guided-Inquiry Module. Metode yang digunakan dalam penelitian ini adalah metode penelitian tindakan kelas. Subjek penelitian adalah 1 kelas mahasiswa yang mengambil mata kuliah Fisika Dasar pada semester ganjil tahun ajaran 2019/2020. Hasil penelitian menunjukkan bahwa rata-rata nilai pengetahuan konten mahasiswa adalah sebesar 50.56 pada siklus I, 60.76 pada siklus II, dan 70.08 pada siklus III. Persentase ketuntasan belajar yang diperoleh kelas adalah sebesar 20% pada siklus I, 24% pada siklus II, dan 56% pada siklus III. Berdasarkan hasil penelitian tersebut,dapat disimpulkan bahwa terdapat peningkatan pengetahuan konten mahasiswa setelah mengikuti pembelajaran dengan metode praktikum virtual berbasis simulasi PhET berbantuan guided-inquiry module. Kata kunci: Pengetahuan Konten Fisika,Praktikum Virtual, Simulasi PhET, Guided-Inquiry Module AbstractThis research aimed to determine the increase in student's physics content knowledge through the application of a virtual practicum method based on a PhET simulation assisted by the guided-inquiry module. The method used in this research was a classroom action research method. The research subjects were 1 class of students who took the Basic Physics course in odd semester of the 2019/2020 academic year. The results showed that the average score of student content knowledge was 50.56 in the first cycle, 60.76 in the second cycle, and 70.08 I n the third cycle. The percentage of subject matter mastery obtained by the class was 20% in the first cycle, 24% in the second cycle, and 56% in the third cycle. Based on these results, it can be concluded that there is an increase in student’s physics content knowledge after participating in learning with a virtual practicum method based on a PhET simulation assisted by the guided-inquiry module. Keywords : Physics Content Knowledge, Virtual Practicum, PhET Simulation, Guided-Inquiry Module
PENGEMBANGAN HANDOUT FISIKA BERBASIS CONTEXTUAL TEACHING AND LEARNING (CTL) UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR FISIKA SISWA SMA
Authors: Amin Ahmad , Sulistiyono Sulistiyono 
Published: May 2021

Penelitian pengembangan ini bertujuan untuk: (1) menghasilkan produk berupa handout fisika berbasis contextual teaching and learning yang layak untuk meningkatkan aktivitas dan hasil belajar fisika siswa; (2) mengetahui besar peningkatan aktivitas belajar siswa setelah menggunakan handout fisika berbasis contextual teaching and learning dan (3) mengetahui besar peningkatan hasil belajar fisika siswa setelah menggunakan handout fisika berbasis contextual teaching and learning. Penelitian ini merupakan penelitian pengembangan (R&D) dengan model 4D (FourD Models), yaitu: tahap Define, Design, Develop, dan Disseminate. Instrumen penelitian ini berupa lembar validasi handout, lembar observasi aktivitas belajar dan soal tes hasil belajar siswa. Hasil penelitian menunjukkan bahwa 1) Handout fisika berbasis CTL hasil pengembangan layak digunakan untuk meningkatkan aktivitas dan hasil belajar fisika siswa dengan kategori sangat baik; 2) Peningkatan aktivitas belajar siswa dengan menggunakan handout fisika berbasis CTL ditunjukkan dengan nilai standard gain sebesar 0,72 dengan kategori tinggi dan 3) peningkatan hasil belajar fisika sebesar 0,92 dengan kategori tinggi.
Spirometric Indices in Type 2 Diabetes Mellitus Patients in a Nigerian Tertiary Institution
Authors: Adeoti Adekunle O. , Raimi Taiwo H. , Fadare Joseph O. , Ibidapo Raphael 
Published: May 2021

Background: Diabetes mellitus is a non-communicable disease of global health importance. It is a metabolic disorder caused by increased levels of blood glucose over a prolonged period of time. Type 2 diabetes mellitus (T2DM) is usually associated with obesity and insulin resistance. Several studies have also revealed that diabetes mellitus hampers pulmonary functions. This study was aimed at estimating the spirometric indices in type 2 diabetes mellitus patients.
Methods: A cross-sectional study of T2DM patients and apparently healthy control attending the medical outpatient clinic in a tertiary institution in south western Nigeria.
Results: A total of 146 participants with 73 patients with T2DM and 73 control groups. There were no significant differences in the age, body mass index, and gender distribution of the diabetics and control. However, patients with diabetes had higher SBP (133.2±20.17 mmHg vs 111.6±6.5 mmHg p<0.0001), and DBP (78.4±11.8mmHg vs 73.7±6.3 mmHg, p=0.003) when compared to the control. The mean FEV (1.98±0.5 vs 2.09±1.2, p=0.033), FVC (2.35±0.6 vs 2.53±1.3, p=0.045) and FEV/FVC ratio (83.61±7.2 vs 81.14±10.7, p=0.029) were significantly lower in diabetic patients when compared to matched controls. There was no significant difference in the PEF and FEF of both groups.
Conclusion: Type 2 diabetes mellitus patients had significant decrease in their spirometric indices, hence pulmonary function should be included in the periodic comprehensive diabetic check for holistic management.
DAMPAK MEDIA SOSIAL PADA KINERJA UMKM DI KOTA BANDAR LAMPUNG
Authors: Arinda Anggun Yustia 
Published: May 2021

Pemanfaatan perkembangan teknologi informasi banyak sekali digunakan untuk mengembangkan bisnis, baik dari perusahaan maupun dari individu. Perkembangan teknologi digital yang cukup pesat selama beberapa tahun terakhir memberikan dampak besar pada berbagai pelaku ekonomi yang ada, termasuk para pelaku UMKM untuk bertahan dan terus bersaing. Penelitian ini mengkaji dampak adanya media sosial terhadap kinerja UMKM di Kota Bandar Lampung. Penelitian ini menggunakan data primer dengan metode survey secara langsung terdahap 100 responden pelaku usaha UMKM dengan berbagai industri di Kota Bandar Lampung. Berdasarkan analisis deskriptif kuantitatif dan deskriptif kualitatif penelitian ini menemukan bukti empiris bahwa media sosial berpengaruh positif terhadap kinerja pejualan, kinerja pemasaran, dan interaktivitas. Namun masih kurang berpengaruh terhadap peningkatan jumlah pegawai