bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rituximab for the Treatment of Common Variable Immunodeficiency (CVID) with Pulmonary and Central Nervous System Involvement
Authors: Strunz Patrick-Pascal , Fröhlich Matthias , Gernert Michael , Schwaneck Eva C. , Nagler Lea-Kristin , Kroiss Anja , Tony Hans-Peter , Schmalzing Marc 
Published: April 2021

Background:
Granulomatous and lymphocytic interstitial lung disease (GLILD) represents a typical form of pulmonary manifestation of CVID. Except for glucocorticoid- and immunoglobulin-administration, no standardized treatment recommendations exist.

Objective:
To investigate our CVID-patients with GLILD for the applied immunosuppressive regimen, with a focus on rituximab.

Methods:
A retrospective analysis of all CVID-patients for the manifestation and treatment of GLILD at a single German center was performed in this study. For the evaluation of treatment-response, CT-imaging and pulmonary function testing were used.

Results:
50 patients were identified for the diagnosis of a CVID. 12% (n = 6) have radiological and/or histological confirmed diagnosis of a GLILD. Three patients received rituximab in a dose of 2 x 1000mg, separated by 2 weeks repeatedly. All patients showed radiological response and stabilization or improvement of the pulmonary function. Rituximab was used in one patient over 13 years with repeated treatment-response. Furthermore, the synchronic central nervous system-involvement of a GLILD-patient also responded to rituximab-treatment. With sufficient immunoglobulin-replacement-therapy, the occurring infections were manageable without the necessity of intensive care treatment.

Conclusion:
Rituximab might be considered as an effective and relatively safe treatment for CVID-patients with GLILD.
FASHION AS SIGN AND SYMBOLIC CONDITIONALITY: PHILOSOPHICAL AND SOCIOLOGICAL ASPECTS
Authors: Ovsiankina Liudmyla , Kuprii Tetiana 
Published: April 2021

The article is dedicated to revealing the specific features of fashion as a system of cultural and aesthetic values, as well as a contradictory social phenomenon which plays an important role as a symbolic regulator of mass society. The purpose of this article is to study the mechanism of creation of the sign and symbolic world of fashion, new models and patterns of behavior, evident and hidden functions of fashion in the era of globalization. Attention is focused on the fact that fashion, as one of the central phenomenon of the modern world, has become an industry based on the principle of rationality, for the production of original trends, in line with the trends and challenges of modern times. It reflects social reality, and people who actively contribute to changing its fashion patterns set in motion models of social reality. It is the sociological study of fashion that can contribute to its most adequate description and explanation. This is due to the fact that the process of spreading and changing fashion patterns is characterized by the value attitude of people both to things and to other people. The result of such an attitude is the social division of people into groups. A fashionable thing, which is desirable for a person, at the same time becomes for him a desirable image of the social status and interpersonal relations to which a person aspires. The article analyzes modern fashion in terms of symbolic conditionality and symbolic reality characterized by features of sociality, temporality, ambivalence and spectacularity. The main attention of authors of the study is devoted to the analysis of the specific behavior of a human-consumer, for whom the sign and symbolic world of fashion is not only a means of self-expression, but also an opportunity to fill the spiritual vacuum and feel a lost sense of stability. Attention is also focused on the importance of solving the problem of ethics of responsibility of modern fashion, which is the determinants of all relations in the sphere of contemporary consumer society.
Place zabaw w mieście – dla wszystkich a nie tylko dla dzieci
Authors: Nałęcz Hanna , Ostrowska-Tryzno Anna , Pawlikowska-Piechotka Anna 
Published: April 2021

Podczas gdy w przeszłości place zabaw były zazwyczaj przeznaczone tylko dla dzieci, dziś możemy obserwować więcej miejsc publicznych, terenów sportu i wypoczynku przeznaczonych dla wszystkich grup wiekowych, w tym osób dorosłych i w wieku podeszłym. Tradycyjne place zabaw wyposażone są w sprzęt rekreacyjny adresowany do użytkowników najmłodszych: huśtawki, zjeżdżalnie i karuzele, natomiast place zabaw o charakterze uniwersalnym mają również wyposażenie atrakcyjne dla osób dorosłych, takie jak boisko do koszykówki czy szachy. Te udogodnienia pozwalają rodzinom spędzać czas wspólnie, rozwijać koordynację fizyczną, siłę, elastyczność poczucia własnej wartości i umiejętności społeczne, a także zapewnić rekreację i przyjemność. Na podstawie publicznych placów zabaw mieszczących się w Warszawie autorzy próbowali odpowiedzieć na następujące pytania: które urządzenia pomagają pobudzać i rozwijać umiejętności społeczne, umysłowe i fizyczne oraz jakie są najczęstsze sugestie użytkowników w sprawie zmian i ulepszeń? Z wykorzystaniem badania terenowego (obserwacje uczestników, wywiady strukturalne i semistrukturalne) określono wiele czynników subiektywnych i obiektywnych, które mogłyby określić potencjał „inkluzyjnego terenu rekreacji”. Wyróżniono silne i słabe punkty placów zabaw (dostępność, lokalizację, atrakcyjność urządzeń, ich poziom bezpieczeństwa), a także oceniono relacje między zestawem urządzeń a płcią, grupą wiekową, stymulacją fizyczną i psychiczną – za pomocą przyjętych kryteriów. Uniwersalne, zintegrowane place zabaw (dla zróżnicowanych grup wiekowych) powinny być dostępne dla wszystkich członków społeczności, w tym seniorów i osób niepełnosprawnych. Aby to osiągnąć, należy przestrzegać podstawowych zasad: dostępności, infrastruktury przeznaczonej dla użytkowników o różnych możliwościach fizycznych i wieku, dostosowanych do oczekiwań i zainteresowań społeczności lokalnej. Jak się okazuje, inspirujące i ekscytujące urządzenia, atrakcyjnie urządzony i dostępny teren sportu i rekreacji jest ważny, aby zachęcić do codziennej aktywności fizycznej, ma znaczenie integrujące i pomaga w zacieśnianiu więzi społecznych. Artykuł powstał na podstawie materiału badań w ramach projektu statutowego ds. -300 AWF zrealizowanego w Akademii Wychowania Fizycznego Józefa Piłsudskiego w Warszawie, dzięki dotacji grantu Ministerstwa Nauki i Szkolnictwa Wyższego.
Piękno – geneza i funkcje
Authors: Pala Janusz 
Published: April 2021

Piękno jest jedną z charakterystycznych cech harmonii świata. Spełnia ono również ważne funkcje biologiczne, sprzyjając przetrwaniu człowieka jako gatunku w warunkach naturalnych. Poczucie piękna ma charakter uniwersalny i jest uwarunkowane genetycznie. W wyniku tego rzeczy piękne były takimi zarówno dla człowieka pierwotnego, jak dla żyjącego współcześnie. Podstawą piękna jest symetria. Jednostkami symetrii są fraktale. Geometria fraktalna pozwala wykryć piękno ukryte w pozornie chaotycznych strukturach.
Urban renewal in post-industrial districts: the example of Lyon Metropolis
Authors: Coudroy de Lille Lydia , Bouloc Caroline 
Published: April 2021

Urban renewal issues in France are very often discussed with reference to the demolition or renovation of large-scale housing estates. But these issues also concern former industrial areas which have their own distinct architectural, social, and economic difficulties. This article aims to present analysis of these differences using the example of two case studies in the Lyon metropolitan area, the second largest agglomeration in France. First, we outline the background of urban policy in France and Lyon in particular, together with mapping “priority geography” of urban policy in Lyon. Our two case studies, La Saulaie and Carré de Soie, are located in suburbs of the metropolis. Through our analysis of the social and spatial features of these two renewal projects which are currently under way, we demonstrate that urban renewal policies in France are multi-layered, and that the case of Lyon illustrates especially robust engagement on the part of local authorities. Tackling poverty and isolation are the priorities in La Saulaie. In Carré de Soie, the challenges are to create a public transportation hub, a new housing market, and to attract companies to this new secondary centre. We also show that urban renewal operations are not limited to the areas defined by the “priority geography”.
Czy Kazimierz Dolny jest pomnikiem historii?
Authors: Wieczorek Anna 
Published: April 2021

Pozostaje bezspornym, że Kazimierz Dolny ma szczególne wartości dla kultury, a tym samym spełnia wymagania stawiane obiektowi, który chce się uznać za pomnik historii. Niestety, regulacje dotyczące ochrony zabytków: decyzje z 1966 r. i z 1983 r. o wpisie do rejestru zabytków oraz zarządzenie Prezydenta RP z 1994 r. w sprawie uznania za pomnik historii Kazimierza Dolnego budzą szereg wątpliwości natury merytorycznej i prawnej – nie wiadomo czy obowiązują. Taka sytuacja wywołuje konflikty pomiędzy mieszkańcem Kazimierza Dolnego a władzami, w szczególności wojewódzkim konserwatorem zabytków. Dla zapewnienia Kazimierzowi Dolnemu odpowiedniej ochrony konserwatorskiej należy doprowadzić do wyeliminowania z obrotu prawnego ww. decyzji z 1966 r. i z 1983 r. oraz zarządzenia z 1994 r. Następnie powinno zostać wydane rozporządzenie Prezydenta RP w sprawie uznania za pomnik historii, które w sposób jednoznaczny określi przedmiot i zasady ochrony. Wydanie rozporządzenia trzeba poprzedzić badaniami, które w sposób jednoznaczny wskażą obszar podlegający ochronie oraz co i dlaczego na tym obszarze należy chronić. Artykuł należy traktować jako apel o likwidację chaosu prawnego dotyczącego zabytków. W podobnej sytuacji jak Kazimierz Dolny jest kilkanaście obiektów, które uznano za pomniki historii zarządzeniami Prezydenta RP wydanymi w 1994 r. Ochrona zabytków jest obowiązkiem zarówno władz, jak i społeczeństwa. Żeby była skuteczna, nie może być nacechowana uznaniowością. Tylko jednoznacznie, precyzyjnie ustalone obowiązki znajdą akceptacje społeczną, a bez niej trudno coś chronić. Ponadto potrzebna jest szeroko rozumiana edukacja. Karami nie wymusi się wrażliwości na piękno i szacunku dla historii. Uznanie za pomnik historii powinno być traktowane jako zaszczyt przez mieszkańców terenu, który ten status uzyskał, a nie jako „dopust boży”.
Impact of a Face-To-Face Versus Smartphone App Versus Combined Breastfeeding Intervention Targeting Fathers: Randomized Controlled Trial
Authors: Scott Jane Anne , Burns Sharyn K , Hauck Yvonne L , Giglia Roslyn C , Jorgensen Anita M , White Becky Kate , Martin Annegret , Robinson Suzanne , Dhaliwal Satvinder S , Binns Colin W , Maycock Bruce R 
Published: April 2021

Background
Despite the recognized health and economic benefits of exclusive breastfeeding, few Australian infants are exclusively breastfed beyond 5 months of age. Social support for breastfeeding, in particular the support of an infant’s father, has been identified as a crucial element for successful breastfeeding.

Objective
The objective of this study was to determine the effectiveness of various father-focused breastfeeding interventions in terms of key infant feeding outcomes.

Methods
The study was a 4-arm, factorial, randomized controlled trial conducted in Perth, Australia. The trial arms included a control group and 3 interventions, consisting of a face-to-face father-focused antenatal breastfeeding class facilitated by a male peer facilitator; Milk Man, a breastfeeding smartphone app designed specifically for fathers; and a combination of both interventions. Expecting couples were recruited from hospital-based antenatal classes and block randomized to 1 of the 4 arms. Each partner completed surveys at recruitment and at 6 weeks and 26 weeks postpartum. Primary outcomes were duration of exclusive and any breastfeeding. Secondary outcomes included age of introduction of formula and complementary foods, maternal breastfeeding self-efficacy, and partner postpartum support.

Results
A total of 1426 couples were recruited from public (443/1426, 31.1%) and private (983/1426, 68.9%) hospitals. Of these, 76.6% (1092/1426) of fathers completed the baseline questionnaire, 58.6% (836/1426) completed the 6-week follow-up questionnaire, and 49.2% (702/1426) completed the 26-week follow-up questionnaire. The average age of fathers who completed the baseline questionnaire was 33.6 (SD 5.2) years; the majority were born in Australia (76.4%) and had attended university (61.8%). There were no significant differences between the control and any of the intervention groups in any of the infant feeding outcomes or level of breastfeeding self-efficacy and postpartum partner support reported by mothers.

Conclusions
This study did not demonstrate that any intervention was superior to another or that any intervention was inferior to the standard care delivered in routine antenatal classes. Further studies are needed to test the effectiveness of these interventions in more socioeconomically diverse populations that are likely to benefit most from additional partner supports.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12614000605695; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12614000605695

International Registered Report Identifier (IRRID)
RR2-10.1186/s12884-015-0601-5
COVID-19 Rehabilitation With Herbal Medicine and Cardiorespiratory Exercise: Protocol for a Clinical Study
Authors: Gao Yang , Zhong Linda L D , Quach Binh , Davies Bruce , Ash Garrett I , Lin Zhi-Xiu , Feng Yibin , Lau Benson W M , Wagner Peter D , Yang Xian , Guo Yike , Jia Wei , Bian Zhaoxiang , Baker Julien S 
Published: April 2021

Background
Recent studies have revealed that many discharged patients with COVID-19 experience ongoing symptoms months later. Rehabilitation interventions can help address the consequences of COVID-19, including medical, physical, cognitive, and psychological problems. To our knowledge, no studies have investigated the effects of rehabilitation following discharge from hospital for patients with COVID-19.

Objective
The specific aims of this project are to investigate the effects of a 12-week exercise program on pulmonary fibrosis in patients recovering from COVID-19. A further aim will be to examine how Chinese herbal medicines as well as the gut microbiome and its metabolites regulate immune function and possibly autoimmune deficiency in the rehabilitation process.

Methods
In this triple-blinded, randomized, parallel-group, controlled clinical trial, we will recruit adult patients with COVID-19 who have been discharged from hospital in Hong Kong and are experiencing impaired lung function and pulmonary function. A total of 172 eligible patients will be randomized into four equal groups: (1) cardiorespiratory exercise plus Chinese herbal medicines group, (2) cardiorespiratory exercise only group, (3) Chinese herbal medicines only group, and (4) waiting list group (in which participants will receive Chinese herbal medicines after 24 weeks). These treatments will be administered for 12 weeks, with a 12-week follow-up period. Primary outcomes include dyspnea, fatigue, lung function, pulmonary function, blood oxygen levels, immune function, blood coagulation, and related blood biochemistry. Measurements will be recorded prior to initiating the above treatments and repeated at the 13th and 25th weeks of the study. The primary analysis is aimed at comparing the outcomes between groups throughout the study period with an α level of .05 (two-tailed).

Results
The trial has been approved by the university ethics committee following the Declaration of Helsinki (approval number: REC/19-20/0504) in 2020. The trial has been recruiting patients. The data collection will be completed in 24 months, from January 1, 2021, to December 31, 2022.

Conclusions
Given that COVID-19 and its sequelae would persist in human populations, important findings from this study would provide valuable insights into the mechanisms and processes of COVID-19 rehabilitation.

Trial Registration
ClinicalTrials.gov NCT04572360; https://clinicaltrials.gov/ct2/show/NCT04572360

International Registered Report Identifier (IRRID)
PRR1-10.2196/25556
Telepsychiatry Consultation for Primary Care Treatment of Children and Adolescents Receiving Child Protective Services in Chile: Mixed Methods Feasibility Study
Authors: Mundt Adrian P , Irarrázaval Matías , Martínez Pablo , Fernández Olga , Martínez Vania , Rojas Graciela 
Published: April 2021

Background
Children and adolescents living under the supervision of child protective services have complex mental health care needs. The scarcity and uneven distribution of specialized mental health teams in Chile may limit the provision and quality of care for this vulnerable population. Telepsychiatry can address such health inequities.

Objective
The objective of this study was to evaluate the feasibility of a telepsychiatry consultation program for primary health care (PHC) treatment of children and adolescents living under the supervision of child protective services.

Methods
We developed a telepsychiatry consultation program for two rural PHC clinics located in central Chile (Valparaíso Region) and evaluated its implementation using a mixed methods study design. The program consisted of videoconferencing mental health consultation sessions scheduled twice per month (each 90 minutes long), over a 6-month period, delivered by child and adolescent psychiatrists based in Santiago, Chile. We described the number of mental health consultation sessions, participant characteristics, perceived usefulness and acceptability, and experiences with the telepsychiatry consultation program.

Results
During the 6-month study period, 15 videoconferencing mental health consultation sessions were held. The telepsychiatry consultation program assisted PHC clinicians in assigning the most adequate diagnoses and making treatment decisions on pharmacotherapy and/or psychotherapy of 11 minors with complex care needs. The intervention was perceived to be useful by PHC clinicians for improving the resolution capacity in the treatments of this patient population. Limitations such as connectivity issues were resolved in most sessions.

Conclusions
The telepsychiatry consultation program was feasible and potentially useful to support PHC clinicians in the management of institutionalized children and adolescents with complex psychosocial care needs living in a poorly resourced setting. A larger scale trial should assess clinical outcomes in the patient population. Regulations and resources for this service model are needed to facilitate sustainability and large-scale implementation.
Evaluation of an Intrahospital Telemedicine Program for Patients Admitted With COVID-19: Mixed Methods Study
Authors: Legler Sean , Diehl Matthew , Hilliard Brian , Olson Andrew , Markowitz Rebecca , Tignanelli Christopher , Melton Genevieve B , Broccard Alain , Kirsch Jonathan , Usher Michael 
Published: April 2021

Background
The increasing incidence of COVID-19 infection has challenged health care systems to increase capacity while conserving personal protective equipment (PPE) supplies and minimizing nosocomial spread. Telemedicine shows promise to address these challenges but lacks comprehensive evaluation in the inpatient environment.

Objective
The aim of this study is to evaluate an intrahospital telemedicine program (virtual care), along with its impact on exposure risk and communication.

Methods
We conducted a natural experiment of virtual care on patients admitted for COVID-19. The primary exposure variable was documented use of virtual care. Patient characteristics, PPE use rates, and their association with virtual care use were assessed. In parallel, we conducted surveys with patients and clinicians to capture satisfaction with virtual care along the domains of communication, medical treatment, and exposure risk.

Results
Of 137 total patients in our primary analysis, 43 patients used virtual care. In total, there were 82 inpatient days of use and 401 inpatient days without use. Hospital utilization and illness severity were similar in patients who opted in versus opted out. Virtual care was associated with a significant reduction in PPE use and physical exam rate. Surveys of 41 patients and clinicians showed high rates of recommendation for further use, and subjective improvements in communication. However, providers and patients expressed limitations in usability, medical assessment, and empathetic communication.

Conclusions
In this pilot natural experiment, only a subset of patients used inpatient virtual care. When used, virtual care was associated with reductions in PPE use, reductions in exposure risk, and patient and provider satisfaction.
Technology Acceptance and Usability of the BrainFx SCREEN in Canadian Military Members and Veterans With Posttraumatic Stress Disorder and Mild Traumatic Brain Injury: Mixed Methods UTAUT Study
Authors: Jones Chelsea , Miguel-Cruz Antonio , Brémault-Phillips Suzette 
Published: April 2021

Background
Canadian Armed Forces service members (CAF-SMs) and veterans exhibit higher rates of injuries and illnesses, such as posttraumatic stress disorder (PTSD) and traumatic brain injury, which can cause and exacerbate cognitive dysfunction. Computerized neurocognitive assessment tools have demonstrated increased reliability and efficiency compared with traditional cognitive assessment tools. Without assessing the degree of technology acceptance and perceptions of usability to end users, it is difficult to determine whether a technology-based assessment will be used successfully in wider clinical practice. The Unified Theory of Acceptance and Use of Technology model is commonly used to address the technology acceptance and usability of applications in five domains.

Objective
This study aims to determine the technology acceptance and usability of a neurocognitive assessment tool, which was titled BrainFx SCREEN, among CAF-SMs and veterans with PTSD by using the Unified Theory of Acceptance and Use of Technology model.

Methods
This mixed methods embedded pilot study included CAF-SMs and veterans (N=21) aged 18-60 years with a diagnosis of PTSD who completed pre- and postquestionnaires on the same day the BrainFx SCREEN was used. A partial least squares structural equation model was used to analyze the questionnaire results. Qualitative data were assessed using thematic analysis.

Results
Facilitating conditions, which were the most notable predictors of behavioral intention, increased after using the BrainFx SCREEN, whereas effort expectancy decreased. Performance expectancy, effort expectancy, and social interaction were not factors that could predict behavioral intention. Participants who reported a previous mild traumatic brain injury were significantly more likely to report current symptoms of cognitive impairment. The BrainFx SCREEN is a feasible, usable, and accepted assessment tool for CAF-SMs and veterans who experience PTSD.

Conclusions
As military health care systems integrate technological innovations to improve the services and care provided, research must continue to address the acceptability and use of these novel assessments and interventions.