bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world Risk of Relapse of Giant Cell Arteritis Treated With Tocilizumab: A Retrospective Analysis of 43 Patients
Authors: Clément Jérémy , Duffau Pierre , Constans Joel , Schaeverbeke Thierry , Viallard Jean-Francois , Barcat Damien , Vernhes Jean-Philippe , Sailler Laurent , Bonnet Fabrice 
Published: February 2021

ObjectiveTocilizumab (TCZ), an interleukin 6 (IL-6) receptor antagonist, is approved for giant cell arteritis (GCA) as a cortisone-sparing strategy and in refractory patients. This study assessed the real-world efficacy, safety, and long-term outcomes of patients with GCA treated with TCZ.MethodsWe conducted a multicenter retrospective observational study at 3 French centers. All patients aged ≥ 50 years who met the American College of Rheumatology (ACR) criteria, and had received at least 1 dose of TCZ were included. Relapse was defined by therapeutic escalation, such as increased doses of corticosteroids (CS), resumption of CS after weaning, or introduction or intensification of adjuvant therapy.ResultsBetween 2013 and 2019, 43 patients were included. Patients were followed up for a median 511 days between GCA diagnosis and inclusion, with 34/43 (79%) patients experiencing relapses. At inclusion, median age was 77 years, and median dose of CS was 15 mg/day. After inclusion, the mean cumulative dose of CS was 2.1 g/year vs 9.4 g/year before inclusion (P < 2 × 10–7), with 12/43 (28%) patients experiencing relapses on TCZ. Among 29 patients undergoing TCZ discontinuation, 18 (62%) experienced relapses. Factors associated with relapse after inclusion were introduction of TCZ > 6 months after diagnosis (P = 0.005), absence of ischemic signs at diagnosis (P = 0.006), relapse rate > 0.8/year (P = 0.03), and absence of CS tapering ≤ 5 mg/day (P = 0.03) before inclusion. Serious adverse events occurred in 18/43 patients (42%), including 4 deaths.ConclusionOur results confirm the effectiveness of TCZ for CS sparing, but after discontinuation of treatment, TCZ allows for a prolonged remission in < 50% of patients. Attention must be paid to the tolerance of this long-term treatment in this elderly, heavily treated refractory population.
Similarity of Response to Biologics Between Elderly-onset Rheumatoid Arthritis (EORA) and Non-EORA Elderly Patients: From the FIRST Registry
Authors: Ochi Sae , Mizoguchi Fumitaka , Nakano Kazuhisa , Tanaka Yoshiya 
Published: February 2021

ObjectiveIncreasing numbers of patients are developing rheumatoid arthritis (RA) at an older age, and optimal treatment of patients with elderly-onset RA (EORA) is attracting greater attention. This study aimed to analyze the efficacy and safety of biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in EORA and non-EORA elderly patients.MethodsA cohort of patients with RA treated with b/tsDMARDs were retrospectively analyzed. Only patients aged ≥ 60 years were included. Among them, patients who developed RA aged ≥ 60 years were categorized as EORA, whereas those aged < 60 years were categorized as non-EORA elderly. Disease activity was compared between the EORA and non-EORA elderly groups.ResultsIn total, 1040 patients were categorized as EORA and 710 as non-EORA elderly. There were no significant differences in characteristics at baseline between the 2 groups. The proportion of patients with low and high disease activity was comparable at Weeks 2, 22, and 54 between the EORA and the non-EORA elderly group. There were no significant differences in the reasons for the discontinuation of b/tsDMARDs between the 2 groups. Elderly RA onset did not affect changes in Clinical Disease Activity Index (CDAI) and Health Assessment Questionnaire–Disability Index, nor did it affect the reasons for b/tsDMARD discontinuation between the 2 groups. The trajectory analysis on CDAI responses to b/tsDMARDs for 54 weeks identified 3 response patterns. The proportion of patients categorized into each group and CDAI response trajectories to b/tsDMARDs were very similar between EORA and non-EORA elderly patients.ConclusionCDAI response patterns to b/tsDMARDs and HR of adverse events were similar between EORA and non-EORA elderly patients.
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs
Authors: Kaeley Gurjit S. , Eder Lihi , Aydin Sibel Zehra , Rich Phoebe , Bakewell Catherine J. 
Published: February 2021

ObjectiveAn estimated 40–50% of patients with psoriasis (PsO) have psoriatic nail disease, which is associated with and directly contributes to a greater clinical burden and worse quality of life in these patients. In this review, we examine how recent advances in the use of new diagnostic techniques have led to improved understanding of the link between nail and musculoskeletal manifestations of psoriatic disease (PsD; e.g., enthesitis, arthritis) and we review targeted therapies for nail PsO (NP).MethodsWe performed a literature search to identify which systemic therapies approved for the treatment of PsO and/or psoriatic arthritis (PsA) have been evaluated for the treatment of NP, either as a primary or secondary outcome. A total of 1546 articles were identified on February18, 2019, and evaluated for relevance.ResultsWe included findings from 66 articles on systemic therapies for the treatment of NP in PsD. With several scoring systems available for the evaluation of psoriatic nail disease, including varied subtypes and application of the Nail Psoriasis Area Severity Index, there was a high level of methodological heterogeneity across studies.ConclusionNP is an important predictor of enthesitis, which is associated with the early stages of PsA; therefore, it is important for rheumatologists and dermatologists to accurately diagnose and treat NP to prevent nail damage and potentially delay the onset and progression of joint disease. Further research is needed to address the lack of both standardized NP scoring systems and well-defined treatment guidelines to improve management of PsD.
Long-term Outcomes and Complications of the New Carlevale Sutureless Scleral Fixation Posterior Chamber IOL
Authors: Vaiano Agostino S. , Hoffer Kenneth J. , Greco Antonio , Greco Andrea , D'Amico Giovanni , Pasqualitto Valerio , Carlevale Carlo , Savini Giacomo 
Published: February 2021

PURPOSE:
To evaluate the visual outcomes and possible complications of a new foldable sutureless scleral fixation intraocular lens (SSF-IOL), the Carlevale IOL (Soleko).

METHODS:
The SSF-IOL, which has two T-shaped self-blocking plugs on each haptic, was inserted into the posterior chamber. Both haptics was grabbed through two sclerotomies and the two short arms were blocked under the scleral flap, without any suture. A complete clinical evaluation was done preoperatively and at 3, 6, and 12 months postoperatively.

RESULTS:

A total of 54 eyes of 50 consecutive patients were retrospectively analyzed. The mean corrected distance visual acuity was 0.93 ± 0.61 logMAR preoperatively and improved to 0.42 ± 0.34 logMAR at 3 months, 0.42 ± 0.37 logMAR at 6 months, and 0.38 ± 0.38 logMAR at 12 months postoperatively (all
P
< .0001). The mean corneal endothelial cell density decreased from 1,725.37 ± 528.06 to 1,612.81 ± 522.91 cells/mm
2
at 12 months postoperatively (
P
< .0001). The mean IOL tilt value was 3.1 ± 1.1° at 12 months postoperatively. The authors observed 6 cases (11.1%) of intraoperative rupture of the IOL haptics, 4 cases (7.4%) of early hyphema, 4 cases (7.4%) of macular cystoid edema, 2 cases (3.7%) of haptic exposure under the conjunctiva, and 1 (1.8%) late retinal detachment.

CONCLUSIONS:
This newly introduced surgical technique provided promising results regarding efficacy and safety. Complications occurred in a few cases and were successfully managed. The Carlevale IOL seems to be a surgical solution combining the advantages of an easy and minimally invasive implantation with a good functional recovery with minimal complications.

[
J Refract Surg
. 2021;37(2):126–132.]
Improving Teen Girls' Skills for Using Electronic Health Information
Authors: Zaim Hannah , Keedy Hannah , Dolce Millie , Chisolm Deena 
Published: February 2021

Background:
In a world increasingly dependent on the Internet for information, it is not surprising that people use the internet to find answers to their health-related questions. Research has shown that teen girls are more likely to search for health information online than boys, but that they do not feel confident in using the information they find.

Objective:
To address this disparity, teen girls were engaged in the process of developing a teen-friendly, internet-based tool that explains the best way to find, evaluate, and use online health information.

Methods:
Focus groups were held with girls and their parents to inform the design of the tool. After collaborating with information technology, marketing, and video production teams, a tool was developed consisting of a webpage, videos, and an interactive game. The efficacy and acceptability of the tool were tested among our target demographic through a usability trial.

Key Results:
Parent and teen focus groups informed the three-step design of the tool. Teen girls reported significantly higher levels of eHealth literacy after using the tool. Dissemination of the tool through a national targeted ad campaign generated web traffic to the tool.

Conclusions:

An internet-based training tool has been shown to improve teen girls' eHealth literacy. Findings from this developmental study can be used to inform efforts to improve eHealth literacy in adolescent girls.

[
HLRP: Health Literacy Research and Practice.
2021;5(1):e26–e34.]

Plain Language Summary:
This research study used teen and parent input to help design an internet-based training tool to teach teen girls the best way to use the internet to find health information. Teen girls' ability to find, understand, and evaluate online health information significantly improved after using the tool. The tool was advertised throughout the United States on various social media platforms.
Interculturalité et apprentissage à distance en formation d’enseignants
Authors: Chartofylaka Lamprini , Odacre Elisabeth , Delcroix Antoine 
Published: February 2021

L’étude rend compte d’une expérimentation, réalisée dans le cadre du projet « Technologies éducatives pour l'enseignement en contexte – TEEC », ayant mis en contact des étudiants de l’Université des Antilles et de l’Université du Québec à Montréal. Ces étudiants se destinent au métier de professeur et bénéficient tous d’un enseignement d’histoire. Les traits culturels (communs et spécifiques) des deux territoires ont été exploités dans un scénario pédagogique élaboré avec l’objectif de contribuer à la construction de conceptions robustes sur des concepts sociaux historiques communs aux deux programmes de formation. Une série d’échanges synchrones (par visioconférence) entre les étudiants montre qu’ils prennent conscience que les mêmes concepts peuvent être enseignés au travers d’entrées thématiques différentes, dépendant d’éléments socioculturels propres à chaque territoire. Cependant, leurs conceptions restent conditionnées par les approches retenues dans l’enseignement scolaire qu’ils ont suivi.
Profile of Kawasaki disease at a tertiary care center in India
Authors: Bhattad Sagar , Gupta Sandip , Israni Neha , Mohanty Sweta 
Published: February 2021

Background:
Kawasaki disease (KD) is the most common cause of acquired heart disease in developed countries. KD is increasingly being reported from India; however, studies involving the large number of patients are few.

Methods:
All children presenting to the center from January 2017 to December 2019, diagnosed to have KD, were retrospectively included in the study. Clinical and laboratory profiles, including echocardiograms, were reviewed. Factors contributing to intravenous immunoglobulin (IVIg) refractoriness and the development of coronary artery abnormalities (CAA) were assessed.

Results:
A total of 39 children with KD presented to the center during the study. While 32 received initial treatment at our center, seven were referred after the initial IVIg infusion. The age range was 2 months to 11 years (mean 42.15 ± 38.51 months). More than two-thirds of the cohort was male (n = 27/39). Mucosal involvement was the commonest clinical abnormality for the group, followed by rash. Hemoglobin was significantly lower in the group with coronary artery involvement (P = 0.001). CAA (61.5%), incomplete KD, and atypical features were much more common in infants compared to the rest. Refractoriness to treatment was significantly more common in infants (P = 0.029).

Conclusions:
A significant proportion of infants with KD had cardiac involvement. Infants were more likely to have IVIg-resistant disease.
Steroid Response Rate in Childhood Nephrotic Syndrome at a Tertiary Hospital in South-Eastern Nigeria
Authors: Ibeneme Chikaodili Adaeze , Ezuruike Ezinwa Olekaibenma , Onuh Emeka Felix 
Published: February 2021

Background:
Response to corticosteroids in childhood nephrotic syndrome (NS) remains the best prognostic marker of the disease. African children have been noted to respond poorly to corticosteroids. However, recent reports in some parts of Nigeria suggest high steroid responsiveness.

Objectives:
This study was done to determine the steroid response rate and associated clinical variables among children with NS in Umuahia, South-Eastern Nigeria.

Patients and Methods:
A retrospective, descriptive study of all the children managed for NS from June 2013 to June 2018 was retrieved and relevant information obtained. Data analysis was done using the SPSS software version 20.0 for Windows® (IBM SPSS Inc. 2011 Chicago, Illinois, USA).

Results:
A total of 30 children aged 2 years to 15 years with a median of 8 years were studied. Male-to-female ratio was 2:1. Fifteen patients achieved remission with steroid with remission rates of 50% overall and 62.5% among children with idiopathic NS. Patients that achieved remission had a lower mean age (mean difference = -5.13, confidence interval [CI] −7.73, −2.54; P < 0.001) compared to those that had steroid resistance. The frequency of steroid resistance in males was not different from females (odd ratio = 1, CI = 0.22–4.56; χ2 = 0.00 P = 1.00). Children aged 5 years and below had the highest remission rate, whereas those above the age of 10 years were all steroid resistant. There was no significant mean difference in the levels of serum albumin and total cholesterol among the children who achieved remission compared to nonresponders. Frequencies of hematuria, hypertension, and raised serum creatinine were not significantly different between the two groups.

Conclusions:
About two-thirds of children with idiopathic NS in our center achieve complete remission with steroid therapy, whereas about one-third have steroid resistance which predominates after the age of 10 years. Frequency of some clinical variables such as hematuria, hypertension, and raised serum creatinine did not significantly differ among steroid responders compared to nonresponders.
Hepatitis B Virus Knowledge and Vaccination Status among Health-care Workers in Calabar, Nigeria
Authors: Kooffreh-Ada Mbang , Okpokam Dorothy , Chukwudike Evaristus , Oku Afiong , Ameh Soter , Effa Emmanuel 
Published: February 2021

Background and Objectives:
The World Health Organization estimates that 2 million health-care workers (HCWs) are at risk of occupational exposure to hepatitis B virus (HBV), with the majority (90%) of such infections arising in sub-Saharan Africa. This study aimed to determine HBV knowledge and vaccination uptake among HCWs.

Materials and Method:
This was a cross sectional analytical study conducted among 392 HCWs from two major health institutions in Calabar i.e. the University of Calabar Teaching Hospital (UCTH) and the General Hospital Calabar (GHC), Cross river State. Multi-staged sampling method comprising of two stages was used to recruit participants into the study. The study population comprised of doctors, nurses, laboratory scientists/technologist, and other categories of HCWs such as pharmacists, ward orderlies, and mortuary attendants. A semi-structured self-administered questionnaire was used to obtain data on the socio-demographic characteristics of HCWs, the knowledge of HCWs regarding HBV and vaccine. The analysis of data was done using the Statistical Package for Social Sciences version 20.

Study Design:
This was a cross-sectional, study of HCWs in Calabar.

Sampling Method:
Multi-staged sampling method was used to select participants from two major health institutions in Calabar, i.e., the University of Calabar Teaching Hospital (UCTH) and the General Hospital Calabar (GHC). Thereafter, through balloting, simple random sampling technique was used to recruit the participants.

Study Population:
Three hundred and ninety-two HCWs were recruited from UCTH and GHC under the following categories: doctors, nurses, laboratory scientists/technologist, and other categories of HCWs such as pharmacists, ward orderlies, and mortuary attendants.

Data Management:
A semi-structured self-administered questionnaire was used to obtain data on the socio-demographic characteristics of HCWs, the knowledge of HCWs regarding HBV and vaccine. The analysis of data was done using the Statistical Package for Social Sciences version 20.

Results:
Overall, 67.9% of the respondents were found to have adequate knowledge of HBV vaccination and infection. Less than half (43.4%) of HCWs admitted receiving three doses (i.e., full coverage) of the vaccine. Difficulty in accessing the vaccine (48, 23.4%) was identified as the major reason given for suboptimal vaccination.

Conclusion:
The knowledge of HBV infection and vaccination is quite modest among HCWs in Calabar. Despite this observation, the vaccination status among HCWs is unsatisfactory. The implication of the findings of our study for health policy and practice is to prevent further occupational exposure of HCWs to HBV infection through mandatory vaccination.
Effects of Different Lipid Sources on the Growth Performance and Muscle Fatty Acid Composition of Juvenile Anguilla marmorata
Authors: Gan Lian , Li Xiao-xia , Zhou Li Liu , Zhu Shao Xuan , Dan Xue Ming , Liu Li , Tang Hui-juan , Li Gui feng , Wang Guang jun 
Published: February 2021

The aim of this study was to investigate the effects of different oils on growth performance of juvenile Anguilla marmorata. Five isonitrogenous and isoenergetic experimental diets were formulated to contain fish oil (FO), sunflower oil (SFO), peanut oil (PO), corn oil (CO) and soybean oil (SBO), respectively, as lipid sources each at an inclusion level of 50 g/kg. The diets were fed to apparent satiation for 10 weeks, twice a day to triplicate tanks of 30 fish each with an initial body weight 6.00±0.06 g. Weight gain (WG) and specific growth rate (SGR) of fish fed the FO and SBO diets were markedly higher than those fed the CO diet, while no other difference in WG and SGR were observed among other treatments. Fish fed FO and SBO diets had better feed utilization than the other diet fish groups. Muscle of fish fed the FO diet had significantly higher levels of C20:5n-3 and n-3/n-6 ratio compared with fish fed vegetable oil (VO) diets, while muscle n-6 PUFA and C18:2n-6 content showed an opposite trend. The present results suggest that soybean oil is a suitable replacement for fish oil for Anguilla marmorata. The IJA appears exclusively as a peer-reviewed on-line open-access journal at http://www.siamb.org.il. To read papers free of charge, please register online at registration form. Sale of IJA papers is strictly forbidden.
Nasal Schwannoma
Authors: Singhal Surinder K , Gulati Ankit , Gupta Nitin , Singh Mugdha 
Published: February 2021

Introduction
A schwannoma is a benign nerve sheath tumuor of myelinated nerves arising from Schwann cells. In the head and neck region, the most common site is the eighth cranial nerve (vestibulocochlear). Only 4% of schwannomas seen in the head and neck region arise from the nose and paranasal sinuses involving branches of the trigeminal nerve (ophthalmic or maxillary) or from the autonomic nervous system.

Case Report
A 29 year old female patient presented to the Ear, Nose and Throat Out Patient Department with the complaints of left sided nasal obstruction and left sided nasal bleed. On anterior rhinoscopy, a single, smooth, greyish, non-pulsatile polypoidal mass was seen in the left nasal cavity seeming to be arising medial to middle turbinate. A provisional diagnosis of benign nasal mass was made and the patient underwent excision under general anaesthesia. On histopathology, an impression of Schwannoma was made.

Discussion
Sino-nasal schwannomas are a very rare entity with non specific imaging studies. A confirmatory diagnosis can be made only after histopathology. The treatment modality of choice is surgical excision of the mass, taking care to leave no residual, so as to prevent a recurrence.
Alteration in Status of Olfaction amongst COVID 19 Patients: A Descriptive Study in a Dedicated COVID Hospital of Eastern India
Authors: Mukherjee Monoj , Ray Anupam , Mohanty Arpita , Paul Sekhar 
Published: February 2021

Introduction
COVID 19 patients present with symptoms of respiratory tract infection as it is caused by SARS Cov-2 which is a β corona virus. A significant number of patients may complain of changes in olfaction either at the onset or later. The incidence, severity and recovery from anosmia/hyposmia varies in different patients. This study was done to investigate the effect of COVID 19 on olfactory dysfunction in the Indian population.
Materials & Methods
100 patients admitted with RT-PCR positive reports for SARS Cov-2, in a dedicated COVID hospital in eastern India, were included in this study. Their olfactory function was estimated by pocket smell test (4 items) during ENT examination at bed side. Recovery from anosmia/hyposmia were noted during follow up visits.
Results
In our study 36% of patients had some alteration in smell. Out of the 36%, 12% had anosmia and 24% had hyposmia. Chances of complete recovery is more in patients suffering from anosmia than hyposmia.
Conclusion
Changes in smell sensation is a significant marker for screening and diagnosis of cases of COVID 19. Most of the patients recover completely.
Tinjauan Teologis Tentang Gereja Dan Pertumbuhannya Berdasarkan Kitab Kisah Para Rasul
Authors: Sahari Gunar 
Published: February 2021

Abstract: This study discusses the Theological Review of the Church and Its Growth Based on the Book of Acts. Researchers used qualitative methods to study this topic. After conducting the research, the researchers concluded that the Acts of the Apostles provided an excellent picture of church growth to serve as the biblical basis for studies of church growth today.
Abstrak: Penelitian ini membahas tentang Tinjauan Teologis Gereja dan Pertumbuhannya Berdasarkan Kitab Kisah Para Rasul. Peneliti menggunakan metode kualitatif untuk mengkaji topik ini. Setelah melakukan penelitian, maka peneliti memperoleh kesimpulan bahwa Kisah Para Rasul memberikan gambaran pertumbuhan gereja yang sangat baik untuk dijadikan dasar Alkitab untuk studi-studi pertumbuhan gereja masa kini.