bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset
Authors: Stridh Pernilla , Kockum Ingrid , Huang Jesse 
Published: October 2021

AbstractVitamin D deficiency is associated with an increased risk of multiple sclerosis (MS). However, its effect on the age of disease onset remains unclear. This study examines the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and age of first symptom onset among recently diagnosed MS patients. Serum 25(OH)D was measured from forty MS patients sampled near disease onset. After correcting seasonal variability, the association between 25(OH)D levels, along with other clinical measures such as IgG index, and age at MS onset was examined using multivariable linear regression. Serum 25(OH)D was not correlated with age at onset (P > 0.5). We observed bias among previously reported associations between 25(OH)D and MS disease measures resulting from non-random distribution of sampling by season. After correcting for seasonal 25(OH)D and other clinical measures, only CSF IgG index remained significantly associated with age at disease onset (β = − 5.35, P = 0.028). In summary, we observed no association between age at onset and serum 25(OH)D levels but observed a negative correlation with CSF IgG index, although this will require further investigation.
Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information
Authors: Chen Shaw-Ji , Cheng Jen-Liang , Lee Sheng-An , Wang Tse-Yi , Jang Jyy-Yu , Chen Kuang-Chi 
Published: October 2021

AbstractType 1 diabetes (T1D) is an autoimmune disease. Different factors, including genetics and viruses may contribute to T1D, but the causes of T1D are not fully known, and there is currently no cure. The advent of high-throughput technologies has revolutionized the field of medicine and biology, and analysis of multi-source data along with clinical information has brought a better understanding of the mechanisms behind disease pathogenesis. The aim of this work was the development of a data repository linking clinical information and interactome studies in T1D. To address this goal, we analyzed the electronic health records and online databases of genes, proteins, miRNAs, and pathways to have a global view of T1D. There were common comorbid diseases such as anemia, hypertension, vitreous diseases, renal diseases, and atherosclerosis in the phenotypic disease networks. In the protein–protein interaction network, CASP3 and TNF were date-hub proteins involved in several pathways. Moreover, CTNNB1, IGF1R, and STAT3 were hub proteins, whereas miR-155-5p, miR-34a-5p, miR-23-3p, and miR-20a-5p were hub miRNAs in the gene-miRNA interaction network. Multiple levels of information including genetic, protein, miRNA and clinical data resulted in multiple results, which suggests the complementarity of multiple sources. With the integration of multifaceted information, it will shed light on the mechanisms underlying T1D; the provided data and repository has utility in understanding phenotypic disease networks for the potential development of comorbidities in T1D patients as well as the clues for further research on T1D comorbidities.
DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis
Authors: Zhao Xu , Wang Jizhao , Zhu Rui , Zhang Jing , Zhang Yunfeng 
Published: October 2021

AbstractCisplatin (CDDP) based chemotherapy is widely used as the first-line strategy in treating non-small cell lung cancer (NSCLC), especially lung squamous cell carcinoma (LUSC). However, secondary cisplatin resistance majorly undermines the cisplatin efficacy leading to a worse prognosis. In this respect, we have identified the role of the DLX6-AS1/miR-181a-5p/miR-382-5p/CELF1 axis in regulating cisplatin resistance of LUSC. qRT-PCR and Western blot analysis were applied to detect gene expression. Transwell assay was used to evaluate the migration and invasion ability of LUSC cells. CCK-8 assay was used to investigate the IC50 of LUSC cells. Flow cytometry was used to test cell apoptosis rate. RNA pull-down and Dual luciferase reporter gene assay were performed to evaluate the crosstalk. DLX6-AS1 was aberrantly high expressed in LUSC tissues and cell lines, and negatively correlated with miR-181a-5p and miR-382-5p expression. DLX6-AS1 expression was enhanced by H3K4me1 in cisplatin resistant LUSC cells. Besides, DLX6-AS1 knockdown led to impaired IC50 of cisplatin resistant LUSC cells. Furthermore, DLX6-AS1 interacted with miR-181a-5p and miR-382-5p to regulate CELF1 expression and thereby mediated the cisplatin sensitivity of cisplatin resistant LUSC cells. DLX6-AS1 induced by H3K4me1 played an important role in promoting secondary cisplatin resistance of LUSC through regulating the miR-181a-5p/miR-382-5p/CELF1 axis. Therefore, targeting DLX6-AS1 might be a novel way of reversing secondary cisplatin resistance in LUSC.
A Preliminary Study of the Relation of Visual Attention to Stimulus Complexity and Functional Vision in Individuals With Cortical Visual Impairment: Implications for Augmentative and Alternative Communication
Authors: McCarty Tara V. , Sowers Dawn J. , Wolf Sophie J. , Wilkinson Krista M. 
Published: October 2021

Purpose:
Individuals with cortical visual impairment (CVI) can have difficulties with visual processing due to physical damage or atypical structures of visual pathways or visual processing centers in the brain. Many individuals with CVI have concomitant disabilities, including significant communication support needs; these individuals can benefit from augmentative and alternative communication (AAC). Because much AAC involves a visual channel, implementation of AAC must consider the unique visual processing skills and challenges in CVI. However, little is known empirically about how to best design AAC for individuals with CVI. This study examined processing of visual stimuli in four young adolescents with CVI.

Method:
This study used a within-subjects experimental design that sought to provide an in-depth description of the visual engagement of individuals with CVI when viewing stimuli of various levels of complexity, either with or without a social cue.

Results:
Participants engaged most with the simplest stimuli (relative to the size of those stimuli) and engaged more when a social cue was provided during the task. The level of engagement with more complex stimuli was related to participants' score on the CVI Range, a clinical assessment tool that characterizes level of visual functioning.

Conclusions:
Implications for AAC include considerations for the internal complexity of AAC symbols and the complexity of the arrays created for individuals with CVI. Clinicians working with children with CVI who use AAC should consider the unique features of their visual processing.
Jetzt die Weichen stellen für ein leistungsfähiges
Forschungsdatenzentrum Gesundheit
Authors: Swart Enno , Gothe Holger , Hoffmann Falk , Ihle Peter , Semler Sebastian Claudius , March Stefanie 
Published: October 2021

ZusammenfassungAuf der Grundlage der §§ 303a bis 303f SGBV werden aktuell die
Weichen für eine innovative und leistungsstarke Informations- und
Datenplattform gestellt. Dies erfordert die aktuelle und kurzfristige
Bereitstellung maßgeblicher Daten des Gesundheitswesens, vor allem von
Prozessdaten der gesetzlichen Krankenversicherung und anderer
Sozialversicherungsträger, unter Anwendung wissenschaftlich anerkannter
Standards und unter gleichzeitiger Einhaltung datenschutzrechtlicher
Bestimmungen. In zehn Empfehlungen werden aus der Sicht künftiger
Nutzer*innen Erwartungen an ein „ideales“ FDZ Gesundheit
gestellt. Der Beitrag richtet sich als Angebot der Wissenschaft und
Versorgungsforschung an Entscheidungsträger im Bereich der Politik und
der Selbstverwaltung im deutschen Gesundheitssystem, diese bei Aufbau und
Weiterentwicklung des FDZ zu unterstützen und kontinuierlich zu
begleiten.
COVID-19 and the Incidence of Acute Myocardial Injury
Authors: Mizera Lars , Borst Oliver 
Published: October 2021

AbstractCardiovascular manifestations are frequent in COVID-19 infection and are predictive of adverse outcomes. Elevated cardiac biomarkers are common findings in patients with cardiovascular comorbidities and severe COVID-19 infection. Troponin, inflammatory and thrombotic markers may also improve risk prediction in COVID-19. In our comprehensive review, we provide an overview of the incidence, potential mechanisms and outcome of acute cardiac injury in COVID-19. Thereby, we discuss coagulation abnormalities in sepsis and altered immune response as contributing factors favoring myocardial injury. We further highlight the role of endothelial damage in the pathophysiological concepts. Finally, observational studies addressing the incidence of myocardial infarction during COVID-19 pandemic are discussed.
Detecção de Cutibacterium acnes em amostras de tecidos de cirurgias limpas primárias do ombro – Parte I
Authors: Miyazaki Alberto Naoki , Checchia Caio Santos , Fonseca Filho João Manoel , Gonçalves Guilherme Vieira , Conte Luiz Henrique Gallego , Sella Guilherme do Val 
Published: October 2021

Resumo
Objetivo Identificar agentes bacterianos em amostras de cirurgias do ombro de pacientes sem histórico de infecção e de cirurgias prévias no ombro.
Métodos Amostras de tendão, bursa e osso foram coletadas no intraoperatório, armazenadas em frascos estéreis a seco e enviadas para análise de crescimento de cultura em meios para agentes aeróbios e anaeróbios no laboratório credenciado ao hospital. Foram analisados os resultados de 141 amostras de 47 ombros.
Resultados Obtivemos resultados de culturas negativas em 46 casos (97,8%) e em 140 amostras (99,2%). Apenas um paciente apresentou resultado positivo, com crescimento bacteriano do Staphylococcus hominis em uma das três amostras coletadas.
Conclusões Não evidenciamos taxas de crescimento bacteriano condizentes com a literatura internacional, alertando para a baixa eficácia dos métodos laboratoriais utilizados no nosso país.
Validation of RNA Aptamer Probes to Image Candida albicans in Paraffin-Embedded Sections of Wistar Rat Tongue
Authors: Bachtiar Boy M. , Srisawat Chatchawan , Rahayu Retno Pudji , Soedjodono Retno D. , Prabandari Silvia Arin , Bachtiar Endang W. 
Published: October 2021

Abstract
Objective This study aimed to validate the use of Ca-apt-1, an RNA aptamer, that we generated previously as a probe for immunostaining of Candida albicans in rat tongue paraffin-fixed tissue sections
Material and Methods The performance of Ca-apt-1 as a detector molecule was compared with that of anti-C. albicans polyclonal antibody (PcAb), which was used as a positive control. Immunostaining images were visualized by light microscopy and were analyzed by using ImageJ software.
Results Microscopic results demonstrated that Ca-apt-1 specifically recognized and immunostained C. albicans cells of rat tongue candidiasis, with a specificity comparable to that of PcAb. ImageJ analysis showed that the area (pixels) detected by Ca-apt-1 was wider than that detected by the antibody. This indicates that the binding affinity of Ca-apt-1 toward C. albicans was better than that of PcAb on paraffin-embedded tissues.
Conclusion This study demonstrates that Ca-apt-1 can be used as a probe for immunostaining of fixed tissue sections for oral candidiasis diagnosis.
Salivary Atopy Biomarkers in Patients with Geographic Tongue
Authors: Farhad-Mollashahi Leila , Dalirsani Zohreh , Honarmand Marieh , Salimi Saeedeh , Shahabi Nezhad Soudeh 
Published: October 2021

AbstractObjectives Geographic tongue is the mucositis of the dorsal surface of the tongue with no definite etiology, although it may be associated with atopic conditions. In this study, the salivary immunoglobulin E (IgE) and eosinophilic cationic protein (ECP) levels were assessed in patients with geographic tongue to examine the relationship between this condition and allergy-related biomarkers.Materials and Methods In this case-control study, unstimulated saliva was collected from 45 geographic tongue patients and 45 controls, and the salivary IgE and ECP levels were assessed. The data were analyzed with SPSS 20.0 using the Mann–Whitney test with a significance level of p < 0.05.Results The salivary IgE level in the case and control groups was 123.76 ± 8.1 and 74.34 ± 6.2 IU/mL, respectively, and the salivary ECP level was 9.4 ± 6.0 and 7.6 ± 3.2 ng/mL, respectively. There was a statistically significant difference between the two groups in terms of salivary IgE (p = 0.007) and ECP (p = 0.001) levels.Conclusion Salivary IgE and ECP levels increase in patients with geographic tongue. They can, therefore, be used for the initial diagnostic workup and to investigate the possible association of geographic tongue with allergic reactions.
Journalists’ use of social media
Authors: Haapanen Lauri 
Published: October 2021

Abstract
This paper shows that journalists are gradually taking
greater advantage of social media and the interactional affordances it
offers. This means, firstly, that journalists can benefit from social media
not only by monitoring conversations, but also by participating in and
initiating them. Secondly, journalists can not only collect information and
identify sources, but also actively ask for them. Thirdly, journalists can
not only distribute their work, but also market it and brand themselves. As
these interactional extensions enable journalists to already engage with
their audience during the newswriting, the paper concludes by discussing the
potential of social media for improving the transparency of journalistic
work and, therefore, for restoring a trusting relationship between the news
media and their audience.
How oral texts are organized in monolingual and heritage Russian
Authors: Gagarina Natalia , Fichman Sveta , Galkina Elena , Protassova Ekaterina , Ringblom Natalia , Rodina Yulia 
Published: October 2021

Abstract
The present study examines narrative macrostructure, measured as Story Structure (SS) and Story Complexity (SC), in bilinguals speaking Russian as their home/heritage language (L1) and exposed to different societal languages (L2), while focusing on the effects of different L2s, bilingualism, and episodic structure and compares it to monolingual Russian. The Multilingual Assessment Instrument for Narratives (LITMUS-MAIN) was used to elicit narratives in L1/Russian from 162 L2 Finnish, German, Hebrew, Norwegian, or Swedish bilinguals (4- and 6-year-olds) and 21 monolingual Russian children (4-year-olds). Age-matched bilinguals showed similarity in SS (except for children speaking L2 German or Hebrew) and SC. Monolinguals (age range 50–59 months) outperformed younger bilinguals (age range 48–59 months) in SS and SC but performed similarly to older bilinguals (age range 66–83 months). Fine-grained analysis revealed that a well-formed episode might include an Attempt-Outcome sequence combined with Internal States (and not only Goal-Attempt-Outcome) and that children are sensitive to events depicted in each episode. The findings show some evidence for the universality of macrostructure and provide insight into macrostructural knowledge at the episode level. The results are discussed within the theoretical model of multidimensional text organization.
Lexical diversity in bilingual speakers of Croatian and Italian
Authors: Hržica Gordana , Roch Maja 
Published: October 2021

Abstract
The aim of this study was to determine whether measures of lexical diversity (LD) can be used to assess general lexical knowledge. This study focused on 30 sequential Croatian/Italian bilinguals aged between 5 and 7 years, who were compared with 30 Croatian and 30 Italian monolinguals matched in age. LD was assessed from narrative language samples using standard measures and compared with Peabody Picture Vocabulary Test (PPVT) results. Two LD measures, the type-token ratio (TTR) and Maas Index based on TTR transformation, did not differentiate between bilinguals and monolinguals, whereas several other did: total number of words (NTW), number of different words (NDW), measure D, moving average type-token ratio (MATTR) and hypergeometric diversity of D (HD-D). NTW, NDW, D, MATTR and HD-D were predictive of PPVT results for monolinguals, whereas NDW, TNW and D (with replacements, Dr) were predictive of PPVT results for bilinguals. Our results suggest that LD measures can be reliable measures of bilinguals’ vocabulary knowledge and can adequately reflect PPVT results in languages other than English.
Effects of Specific Language Impairment (SLI) and bilingualism on verbal short-term memory
Authors: Meir Natalia 
Published: October 2021

Abstract
The current study assessed independent and combined effects of SLI and bilingualism on tasks tapping into verbal short-term memory (vSTM) with varying linguistic load in two languages (Russian and Hebrew). The study explored the extent to which the presence of SLI is related to limited vSTM storage and bilingualism is associated with reduced vocabulary size.
A total of 190 monolingual and bilingual children aged 5;5–6;8 participated in the current study: 108 sequential Russian-Hebrew bilinguals (18 with SLI), 48 Hebrew monolinguals (13 with SLI) and 34 Russian monolinguals (14 with SLI). Children performed three repetition tasks: forward-digit span (FWD), non-word repetition (NWR) and sentence repetition (SRep); bilingual children were tested in both of their languages.
Results indicated a negative effect of SLI on all experimental tasks tapping into vSTM. The effect of SLI rose as a function of increased linguistic load. Regarding bilingualism, no effect was found on the measure of vSTM with the lowest linguistic load (FWD), while its effect was robust once the linguistic load was increased (SRep). The results reported in this study bring evidence that lower performance on measures of vSTM in children with SLI and bilingual children stem from different sources. Although, children with SLI have limitations of vSTM, deficient vSTM cannot fully account for the linguistic difficulties observed in children with SLI. As for bilingualism, it does not affect verbal storage when the linguistic load is minimal, while poor performance in bilingual children on tasks with greater linguistic load is attributed to smaller vocabulary sizes.
Integration of chirping and apodization of Topas materials for improving the performance of fiber Bragg grating sensors
Authors: Saktioto T , Ramadhan K , Soerbakti Y , Irawan D , Okfalisa  
Published: October 2021

Abstract
The discovery of the fiber Bragg grating (FBG) is an early milestone in developing optical fiber technology, such as optical communication to monitoring material health structures as sensors. For optical communication, the FBG components are capable of filtering functions. As a sensor, it has a high sensitivity immune to electromagnetic wave interference, is small in size, and is resistant to extreme environmental conditions. The sensitivity of the FBG sensor is obtained from the shift in the peak wavelength of each of the temperature and strain quantities. However, the performance of the FBG sensor can be improved by engineering the distribution of the refractive index on the grid with the apodization and chirp functions. Apodization is a technique to improve the performance of the FBG to eliminate noise, narrow the full width half maximum, lower the side lobes of the main lobe, and improve the spectrum ripple factor. Apart from apodization, the chirp function also affects the sensor sensitivity and the refractive index distribution on the grid. Numerical experiments were carried out in designing the FBG component as a sensor using Gaussian apodization and Topas (cyclic olefin copolymer) for several chirp functions. The results show that the Gaussian apodization Topas for all chirp functions as a strain sensor has the same sensitivity, namely 0.84 pm/μstrain while for temperature sensors with the highest sensitivity is obtained at cubic root chirp of 13.82857 pm/°C followed by square root chirp of 13.74286 pm/°C, quadratic chirp 13.71429 pm/°C, and linear chirp 13.4 pm/°C. The Bragg wavelength shift was greater for 1 °C than for the 1 μstrain.
Antioxidant Extraction from Purple Sweet Potato (Ipomea batatas l.) using Ultrasound Assisted Extraction (UAE)
Authors: Yasser M. , Badai M. , Thahir Ridhawati , Sukasri Arifah , Kurniawan  
Published: October 2021

Abstract
Ultrasound technology has been used in extracting the antioxidant reserves the Purple Sweet Potato (Ipomea batatas L.). Total Phenolic Content was determined using the Folin-Ciocalteau method and Antioxidant Activity was measured using the DPPH method. The extract was also characterized using FTIR. The best results were obtained with the Total Phenolic Content of 51.167 ± 0.2887 mg/g in GAE and value of IC50 of 26.7861 mg/L at the extraction temperature of 50° C. These results indicate that the purple sweet potato can be used as an immune system booster foods.
Software Engineering Development of Finite Element Method Programming Applications in 2D Frame Structures Using Python Programs
Authors: Nazaruddin N , Siallagan Richard 
Published: October 2021

Abstract
The application of the Finite Element Method as one of the numerical methods to solve various engineering problems is of course inseparable from the development of computers with various other related fields such as Computer Aided Design (CAD) and Computer Aided Engineering (CAE) which continuously becomes a concentration of interest in the engineering field. Element analysis has so far been in great demand by various industries due to its reliability and speed in terms of optimization in the world of design and analysis. There are many finite element software such as Abaqus, Nastran, Ansys, CosmosWork, LS-Dyna, Pro-Mecanica, SAP2000. However, the application is paid at a relatively high cost and has quite strict licensing rules, of course this is an obstacle for students at the University of Riau who want to use it. From these problems the author is interested in developing a programming application that can be an alternative to analyzing a structure. The solution that the author can propose is to develop an application using the python programming language to analyze a two-dimensional (2D) frame structure that is under load and is in an elastic condition. From the results of the research that has been carried out, the simulation results of the frame A model obtained data on the 2nd frame model of frame A, the horizontal displacement of -0.06098 m, the vertical displacement of -0.00002857 m, and the angular displacement of 0.00762 rad. These results are compared with manual solutions, analytical solutions, and previous research, it can be concluded that the results of calculations in the developed application show values that are close to that comparison, where the percentage error is not more than 3%, with the highest percentage difference of 2.5%.