bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between vitamin D levels and mortality rates of critically ill patients in intensive care unit
Authors: SAĞIR Müslüm , KAPLAN Mustafa , TANOĞLU Alpaslan , DEMİREL Fevzi 
Published: April 2021

Introduction: Vitamin D have a pivotal role in bone metabolism. It regulates immunity and inflammation. In this current research, it was aimed to determine whether there is an association between the mortality rate and the vitamin D level of critically ill patients who were followed in intensive care unit (ICU).
Material and Methods: Fifty two patients (30 (58%) female and 22 (42%) male) admitted to ICU with the diagnosis of respiratory failure, sepsis, acute renal failure, multiple organ failure, GIS bleeding were included in the study. During the admission to the ICU, all of the patients’ complete blood count, C-reactive protein, serum calcium, albumin, urea, creatinine, 25-OH vitamin D, potassium, and arterial/venous blood gas levels were measured. Their acceptable mortality risk was calculated according to the APACHE II scoring system.
Results: The level of vitamin D was found at least 1 up to 78.6 range, and the average was 19.61 ng/dl. Eighteen (35%) patients were discharged and 34 (65%) of the ICU patients were died. Vitamin D deficiency was observed to be a very common issue in our critically ill patients (65.4%). The difference between the two groups of age, accepted mortality and urea levels were found to be statistically significant (p
Relics of Supermassive Black Hole Seeds: The Discovery of an Accreting Black Hole in an Optically Normal, Low Metallicity Dwarf Galaxy
Authors: Cann Jenna M. , Satyapal Shobita , Rothberg Barry , Canalizo Gabriela , Bohn Thomas , LaMassa Stephanie , Matzko William , Blecha Laura , Secrest Nathan J. , Seth Anil , Böker Torsten , Sexton Remington O. , Kamal Lara , Schmitt Henrique 
Published: April 2021

Abstract
The detection and characterization of supermassive black holes (SMBHs) in local low mass galaxies is crucial to our understanding of the origins of SMBHs. This statement assumes that low mass galaxies have had a relatively quiet cosmic history, so that their black holes have not undergone significant growth and therefore can be treated as relics of the original SMBH seeds. While recent studies have found optical signatures of active galactic nuclei (AGNs) in a growing population of dwarf galaxies, these studies are biased against low metallicity and relatively merger-free galaxies, thus missing precisely the demographic in which to search for the relics of SMBH seeds. Here, we report the detection of the [Si vi]1.963 μm coronal line (CL), a robust indicator of an AGN in the galaxy SDSS J160135.95+311353.7, a nearby (z = 0.031) low metallicity galaxy with a stellar mass approximately an order of magnitude lower than the LMC (M
* ≈ 108.56
M
⊙) and no optical evidence for an AGN. The AGN bolometric luminosity implied by the CL detection is ≈1042 erg s−1, precisely what is predicted from its near-infrared continuum emission based on well-studied AGNs. Our results are consistent with a black hole of mass ≈105
M
⊙, in line with expectations based on its stellar mass. This is the first time a near-infrared CL has been detected in a low mass, low metallicity galaxy with no optical evidence for AGN activity, providing confirmation of the utility of infrared CLs in finding AGNs in low mass galaxies when optical diagnostics fail. These observations highlight a powerful avenue of investigation to hunt for low mass black holes in the James Webb Space Telescope era.
Denosumab biosimilar in postmenopausal osteoporotic women
Authors: Singh Inderjeet , Jose Vinu , Patel Ronak , Arora Sumit 
Published: April 2021

OBJECTIVE:
The study assessed the efficacy, safety, pharmacokinetic (PK), and immunogenicity profiles of denosumab-biosimilar and denosumab-reference in postmenopausal osteoporotic women from India.

MATERIALS AND METHODS:
In this randomized, assessor-blind, active-control, multicenter trial, 114 patients were randomly allocated to receive denosumab-biosimilar (n = 58) or denosumab-reference (n = 56) at a subcutaneous dose of 60 mg every 6 months, for a year. Vitamin D and oral calcium were given daily. Lumbar spine bone mineral density (BMD) change was the primary end point.

RESULTS:
Of 114 randomized patients, 111 (denosumab-biosimilar, n = 56; denosumab-reference, n = 55) completed the study. All 114 patients were part of safety and immunogenicity analyses, 110 (denosumab-biosimilar, n = 56; denosumab-reference, n = 54) were part of efficacy analysis, and 20 (denosumab-biosimilar, n = 10; denosumab-reference, n = 10) were part of PK analysis. The bone mineral density (BMD) (lumbar spine) percent change at 1 year with denosumab-biosimilar and denosumab-reference (7.22 vs. 7.62; difference:−0.40; 95% confidence interval: −5.92, 5.12) showed no statistically relevant difference. Likewise, alkaline phosphatase (bone-specific) and PK parameters also did not show statistically relevant differences. Adverse events were reported in 44.83% of patients on denosumab-biosimilar versus 33.93% of patients on denosumab-reference; most events were mild or moderate and not related to the study drugs. No patients showed anti-denosumab antibody positivity.

CONCLUSIONS:
Denosumab-biosimilar and denosumab-reference showed biosimilarity in osteoporotic postmenopausal women. Availability of denosumab-biosimilar provides a treatment alternative for patients.
Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity
Authors: Mohamed Mervat , El Sheikh Azza Kamal , Mohammed Hanaa Hassanien 
Published: April 2021

OBJECTIVES:
Methotrexate (MTX) is a broadly used anticancer. Its major side effect is hepatotoxicity. Gossypin is a flavonoid has a hepatoprotective effect as well as antitumor property. The study aimed at inspecting the protective effect of gossypin against MTX hepatotoxicity.

MATERIALS AND METHODS:
Twenty-four adult male rats arranged into four groups (six rats each): control, gossypin control, MTX, and MTX+ gossypin. Animals were orally administered gossypin at 10 mg kg-1 day-1 for 7 days. MTX was injected i.p. (20 mg/kg-1 once) on 5th day. Liver enzyme and oxidative stress markers were assessed. BAX, transforming growth factor-beta (TGF-β) gene expressions, and P-glycoprotein (P-gp) were assessed. The histopathological study as well as the immunohistochemical study for hepatic caspase 3 and nuclear factor kappa-B (NFκ-B) was done.

RESULTS:
MTX produced a significant increase of liver enzymes and distortion of hepatic architecture alongside with increased the hepatic collagen content. MTX administration significantly increased the oxidative stress markers and upregulated the pro-apoptotic BAX and the pro-fibrogenic TGF-β. MTX increased caspase 3 and NFκ-B expression, while diminished the expression of P-gp. Gossypin pretreatment improved the previous parameters, restored the normal hepatic architecture, reduced the hepatic fibrosis, and regained nearly normal expressions for BAX, TGF-β, caspase 3, and NFκ-B. Gossypin caused more reduction in P-gp hepatic expression.

CONCLUSIONS:
Gossypin may be a valuable adjuvant therapy that protects the liver against MTX toxicity through antioxidant, anti-inflammatory, antiapoptotic mechanisms, and mediated P-gp expression reduction.
A study of medication compliance in geriatric patients with chronic illness
Authors: Punnapurath Savithri , Vijayakumar Priya , Platty Princy L. , Krishna Shari , Thomas Thressiamma 
Published: April 2021

Introduction:
Adherence is a multifactorial phenomenon. Usually geriatric patients will have multiple co morbidities because of which poly pharmacy results. This can adversely affect medication compliance. The purpose of our study is to identify various factors responsible for low medication compliance. Elderly people are usually affected with chronic illnesses like Hypertension, Diabates Mellitus, Dyslipidemia, Coronary artery diseases, Osteoarthritis, etc., All these diseases require long-term treatment. So, medication compliance is a very important factor which increases therapeutic outcome.

Materials and Methods:
The study subjects were assessed by using 15 item structured questionnaires as per indigenously modified Morisky Medication Adherence Scale (MMAS).

Results:
A total of 100 patients of geriatric age group were assessed for the level of compliance for long term medication. The compliance level was assessed by providing a 15-item structured questionnaire as per indigenously modified MMAS. The level of compliance was high in 82%, medium in 16% and low in 2% in the first visit. The level of compliance was again assessed during next review visit. The level of score during review visit was high in 74%, medium in 25% and low in 1%.

Conclusion:
The compliance to medication is adversely affected by complicated regimes, ignorance about the disease and complications, physical and economic problems. Geriatric patients especially have a tendency to stop taking drugs off their own when they consider their symptoms have been ameliorated. This can hinder the expected improvement in adherence in the review visit
Patient satisfaction with services at the Family Medicine Employee Clinic in a tertiary hospital in Riyadh
Authors: Allafi Abrar H. , Alqhatani Jarman S , Alruwayshid Mashael S. , Alshuniefi Abeer S. , Alarik Enas F. , Alreshidi Fatmah , Almughais Ebtehaj S. , AlQudairy Reem A 
Published: April 2021

Background:
Patient satisfaction reflects the healthcare quality of the facility. Therefore, it is important to determine satisfaction level of the patient satisfaction in order to improve services'quality provided to patients.

aim:
to assess the satisfaction level of patients at the Family Medicine Employee Clinic at a tertiary hospital in Riyadh, Saudi Arabia. This study is a cross-sectional that included 224 patients.

Method:
The study was conducted in King Fahad Medical City at the Family Medicine Employee Clinic between March and December 2019. Self-administered questionnaires were used to gather the data. The questionnaire included questions regarding the demographics of patients and questions to examine their satisfaction with the services provided by the clinic. SPSS version 21 was used for data analysis.

Results:
The study comprised 90 patients, 71.1% of which were female; 77.8% of participants lived in Riyadh; 92.2% of patients were in the age range of 25–75 years; 51.1% were single; 56.7% had income lower than 10,000 SR; 63.3% had college education; and 95.6% were employees of King Fahd Hospital. The mean ± SD of satisfaction was determined to be at 8.6 ± 1.7. There was a significant inverse correlation between income and satisfaction (P = 0.03).

Conclusion:
Patients reportedly showed high levels of satisfaction, especially regarding the experience of nurses, ease of registration and making appointments, treatment by receptionists, and cleanliness of clinics. The results of the survey reflect the effectiveness and efforts of the employees of the clinic.
Respectful maternity care in public health care facilities in Gujarat
Authors: Raval Hiral , Puwar Tapasvi , Vaghela Prakash , Mankiwala Manshi , Pandya Apurva Kumar , Kotwani Priya 
Published: April 2021

Introduction:
Respectful maternity care (RMC) is not only the marker of quality maternity care but also ensures the protection of basic human rights of every child-bearing woman. This paper discusses the assessment of RMC services during the intrapartum period at public health care facilities in Gujarat state.

Material and Methods:
A cross-sectional research design was used for the study. The data were collected from three different levels of public health facilities such as primary health center (PHC), community health center (CHC), and district hospital (DH) in one of the districts in Gujarat. A standardized tool developed by the United States Agency for International Development based on the RMC charter was used for data collection. A total of 41 pregnant women across three public health facilities were observed during intrapartum care.

Findings:
Most women experienced disrespectful intrapartum care provided at the public health care facilities; however, at-least two performance standards of the RMC charter were met during intrapartum care at each public health care facility. Comparatively, the PHC demonstrated higher RMC performance compliance than DH and the CHC. Most often violations of RMC standards included beneficiaries were not greeted, privacy not maintained, they were not encouraged to ask questions, and support not provided during labor.

Conclusion:
Respectful maternity care is evidently not practiced in public health care facilities. Designing comprehensive behavioral training on RMC, especially for primary, secondary, and tertiary care physicians and nursing staff can improve the adaption of RMC standards in respective public health care facilities. Positive experiences of intrapartum care can potentially improve the uptake of maternal care facilities. Further research is needed to understand local contextual factors, social norms, and patient-provider interactions.
Effect of COVID-19 on control of T1DM patients in Aseer region of Saudi Arabia
Authors: Alqahtani Mohammad Ahmad Awwad , Al Othman Abdullah Othman , Alqahtani Amal Mohammed , AlQahtani Abdullah Mohammed Ahmed , Asiri Fatimah Abdullah Mohammad , Mesfer Alqahtani Mohammed , Alshehri Sahar Dahman , Al-Fifi Suliman H. 
Published: April 2021

Background:
The novel corona virus disease, also known as COVID-19, has emerged as a major health concern globally. Its association with comorbid condition has increased its mortality. Diabetes mellitus (DM) is associated with increased risk of infection in comparison to general population. This risk is higher in type 1 DM that type 2 DM.

Methods:
A cross sectional study was done in T1DM patients in whom a structured questionnaire was administered after lockdown. Data regarding social demographical variables, Information regarding sugar levels, psychological effects, changes in weight, exercise habits and other variables were included in the validated, electronic questionnaire. Ethic approval was obtained from the Diabetic center Abha, study duration was from January-2020 to October-2020.

Results:
Out of 143 total patients (46.9%) were males while 53.1% were females. Mean ± S.D of age was obtained 29.6 ± 1.8. [Figure 1] depicted that 23% of the respondents were effected psychologically. [Figure 2] depicted that 80.4% used insulin as a treatment. [Figure 3] depicted that 8% of the respondents make an emergency visit to the health care centers for high rise in diabetes during lockdown.

Conclusion:
COVID-19 and the lockdown affected the management of T1DM. It resulted in changes in lifestyle, compliance to medication, and psychological impact on the participant.
Assessment of safe handling practices among resident doctors in Jos University Teaching Hospital Plateau state, Nigeria
Authors: Afolaranmi Tolulope O. , Hassan Zuwaira I. , Pam Obadiah S. , Ugwu Lotanna M. , Oyegoke Temidayo I. , Bello Kayode K. , Miner Chundung A. , Ogbeyi Gabriel O. 
Published: April 2021

Background:
Standard safety precautions are essential in health care deliveryregardless of the presumed infectious state of the patients. Safe handling practices as detailed in the universal safety precaution guidelines are available to health care workers globally. However, there have been documentation of suboptimal adherence to it especially in the developing countries including Nigeria. Hence, this study was conducted to assess the level of safe handling practices and its determinants among resident doctors in Jos University Teaching Hospital, Plateau state, Nigeria.

Methods:
This was a cross sectional study conducted among 192 resident doctors using quantitative method of data collection in 2018.SPSS version 20 was used for data analysis with chi square test used to identify the determinants of safe handling practices. Crude odds ratio as well as 95% confidence interval were used with a p-value of < 0.05 considered statistically significant.

Results:
The mean age of the respondents in the study was 33 ± 3 years with 119 (62.0%) of the respondents being males. Good knowledge of infection, prevention and control was reported among 120 (62.5%) while 137 (71.3%) were found to have engaged in safe handling practices. Sex (OR = 4.5; 95% CI = 2.05–9.85) and level of knowledge (OR = 1.97; 95% CI = 1.05–3.72) were found as the determinants of safe handling practice.

Conclusion:
This study has brought to light the need for improvement in the level of compliance with safe handling practices as it is far from the optimum.
Asthma monitoring and lung function in children with physician-diagnosed asthma
Authors: Yiltok Esther S. , Akhiwu Helen O. 
Published: April 2021

Background:
Childhood asthma is the most common chronic lung disease of childhood that requires monitoring including lung function test. This study aimed to evaluate the lung function and the monitoring strategies of children with physician-diagnosed asthma.

Methods:
Children aged 6 to 18 years attending the respiratory clinic with physician-diagnosed asthma were studied. Clinical status and asthma monitoring strategies were obtained followed by spirometry. The tools used for monitoring asthma included symptom diary, peak expiratory flow meter, exacerbations, and use of rescue bronchodilator in the past 1 year.

Results:
There were 45 children aged between 6 and 18 years with 29 (64.4%) females and 16 (35.6%) males. There was no seasonal variation in the development of symptoms and most of the parents and siblings had no allergic conditions. Nearly all children did not use monitoring tools; none of them kept a symptom diary and only one (2.2%) and three (6.7%) had an action plan and peak flow meter, respectively. Only one (2.2%) had a history of being admitted to the intensive care unit (ICU). Thirty-three (73.3%) patients had identifiable triggers (single or multiple) with cold being the most common. Eleven (24.4%) patients had the need to use a rescue bronchodilator in the past 12 months. Thirteen (28.9%) patients had an abnormal spirometric pattern and the most common being the obstructive type.

Conclusion:
The majority of the children had no asthma monitoring tools and a third of them had an abnormal spirometric pattern with the obstructive type being the most common.
Pattern of presentation and visual outcome of glaucoma in a tertiary hospital, Makurdi, Nigeria
Authors: Malu K. N. , Ramyil A. V. , Malu D. D. 
Published: April 2021

Background:
About 15% of blindness in Africa is due to glaucoma. The Nigerian National Blindness and Visual Impairment Survey found that glaucoma accounted for 16.7% of blindness with regional variations. The purpose of the study was to find the regional pattern of presentation and visual outcome to implement preventive measures.

Methods:
This was a descriptive retrospective study of new patients who presented to the eye clinic of Benue State University Teaching Hospital, Makurdi and were diagnosed of glaucoma.

Results:
In this study, 795 consecutive new patients who fulfilled the diagnostic criteria for glaucoma were included. Their mean age was 45.5 ± 18.3. There were 450 (56.6%) males. More patients presented in the fourth and fifth decade of life (n = 299, 37.6%). Primary open-angle glaucoma (inclusive of juvenile open-angle glaucoma, n =595, 74.8%, and normal tension glaucoma, n = 8, 1.0%) accounted for a total of 603 (75.8%). There were 145 (18.2%) glaucoma suspects, 23 (2.9%) primary angle-closure glaucoma, 20 (2.5%) secondary glaucoma, and four cases of congenital glaucoma. Vertical cup-to-disc ratio of ≥0.9 was in 634 (39.9%) of eyes; 274 (34.4%) were bilateral, and were all considered to have severe, advanced or end-stage glaucoma. About 203 (25.5%) had discs asymmetry of ≥0.2. About 355 (22.3%) patients’ eyes were blind: 95 (11.9%) bilateral and 165 (20.8%) uniocular.

Conclusion:
Open-angle glaucoma was most common, and patients presented at a young age with severe eye disease, visual impairment, and blindness.
The Experiences of Ethiopian Unaccompanied and Separated Migrant Children in Yemen
Authors: Molla Bekele , Berhanu Zena 
Published: April 2021

International child migration has become a modern form of brutality. Ethiopia is also one of the source countries for thousands of young migrants leaving their villages in search of better opportunities elsewhere. The article aims to explore the experiences of Ethiopian unaccompanied and separated migrant children in Yemen. The study was conducted using constructivist research paradigm qualitative hermeneutic phenomenological inquiry with a cross sectional exploratory study design. Twelve purposefully selected unaccompanied and separated migrant children returnees from Yemen, with the registered age of sixteen and seventeen, had participated in the study. Data collected through in-depth interviews, focus group discussion and observation were analyzed thematically. The finding indicated dreadful experiences such as detention; bomb attack; physical abuses; emotional problems; imprisonment; starvation; military recruitment; and sexual abuse which were part of the lives of unaccompanied and separated migrant children in Yemen. The study concluded that the experiences of the migrant minors in Yemen were against the universally declared basic human and child rights that recognize the inherent dignity of all human beings and the developmental needs of children in particular. Findings implied points for comprehensive social work practice, and further research endeavors on the topic under investigation.Keywords: Child migrants, Unaccompanied Child, Separated Child, Ethiopia, Experiences, Yemen
Contributions of Youth Centers to the Development of Young People in Ethiopia
Authors: Belay Tefera  , Melese Getu  , Befekadu Zeleke  , Yekoyealem Dessie  
Published: April 2021

There has been a global paradigm shift in conceptualizing how best young persons can be assisted from a conventional deficit-based approach of targeting youth to a more enabling approach of promoting their strengths and competencies. Establishment of youth centers was one such global initiative meant to catalyze positive youth development through supervised and youth-friendly services. In recognition of this, several youth centers have been established in Ethiopia in the last few decades. This research was thus conducted to examine contributions of these centers to the development of young people. Data were collected through questionnaire from a sample of 2,165 participants (service providers and service users) and observation of 94 youth centers drawn from all regions of the country. Findings indicated that the contributions of youth centers were generally minimal in terms of promoting overall positive youth development. Some evidence even showed that youth centers could serve as a platform for acquiring undesirable behaviors among the youth mainly because supervisory and follow up services were not evident. While expanding establishment of youth centers is indeed commendable to ensure access to the greater majority of youth, the need to improve service quality, however, is a priority concern for the relevant actors.