bluuebunny/crossref_metadata_2025_split huggingface dataset:
GIS and remote Sensing based impacts of urban sprawl on the Livelihood of Farming community in Peri-urban areas of Dessie town
Authors: Tefera Jemal 
Published: October 2021

Abstract
The high rate of urbanization coupled with population growth and migration has brought about adjustments in land use and land cover in Ethiopia. consequently, understanding and quantifying the spatio- temporal dynamics of urban land use and land cover changes and its using elements requires lu/lc map integrated with socio economic records. consequently, the objective of this study turned into to assess the effect of urban sprawl on farming communities over the ultimate 30 years of Dessie town. This examines used remote Sensing and Geographic information system for quantifying urban land use and land cover change dynamics. Socio-economic information changed into used to analyze the influences and elements of urban sprawl on prei- urban farming communities. Three dates of Land sat image information of the 1989, 2005 and 2019 had been used to supply land cover map in general and concrete enlargement map particularly. Digitization, image differencing and post-class assessment exchange detection techniques had been employed. Similarly to this, socio-economic facts had been used in explaining the drivers of urban expansion inside the examine location. The consequences showed that over the last 30 years, built-up area increased from 1088.19ha in 1989 to 3826.5hain 2005 and 6091.12 ha inside the yr 2019.the annual rate of built-up area cover exchange among 1988 and 2005 turned into 182.52ha/yr. The socio-economic factors like population growth, rural-urban migration, and reclassification of land is the main using forces for the determined built-up area increment. consequently, with a view to reduce the problem national and regional government policies in terms of urban growth and different responsible body need to get vast interest for city making plans to reduce the charge of the ones factors. Like that of improving vertical expansion in preference to horizontal.
Causes of Death After Rectal Cancer Diagnosis: A population-based study
Authors: Jin Yanyan , Tan GuiRong , Xia Yifan , Wu Lijun 
Published: October 2021

Abstract
BACKGROUND

The focus on non-rectal cancer causes of death in patients with rectal cancer remains superficial. The purpose of the current study was to review the causes of death in rectal cancer survivors.
METHODS

We used the population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in rectal cancer patients. We summarized characteristics of patients after diagnosis and survival outcomes, using Kaplan–Meier analysis and multivariate Cox proportional hazard regression analysis for survival analysis.
RESULTS

The study included 121742 patients who were diagnosed with rectal cancer, of whom 72,007 (59.1%) died during follow-up. Most deaths occurred from rectal cancer (n =31,505, 43.80%), and the number of rectal cancer deaths decreased as more years passed after diagnosis. >10 years after diagnosis, the most common causes of death were heart disease followed by rectal cancer. The 5-year overall survival rate, rectal cancer-specific survival rate, and non-rectal cancer-specific survival rate were 32.0%, 17.3% and 56.6%, respectively. And the 10-year overall survival rate, rectal cancer-specific survival rate and non-rectal cancer-specific survival rate were 14.6%, 4.4% and 31.8%, respectively. On multivariate analysis, factors associated with heart disease-specific survival among rectal cancer survivors include white race, female, married, grade I, earlier stages, surgery and chemotherapy.
CONCLUSIONS

Rectal cancer is the most common cause of death after diagnosis, however, the proportion of non-rectal cancer causes increases with longer survival. Routine follow-up care for rectal cancer survivors should be given more attention than ever.
Modeling biogas technology adoption in Pakistan: A way forward for sustainable research of energy
Authors: Ali Shahid , Yan Qingyou , Elavarasan Rajvikram Madurai , Irfan Muhammad , Abbasi Kashif Raza , Işik Cem 
Published: October 2021

Abstract
The extensive need for energy has become a global issue due to the enormous population growth and demand for electricity-based products. Energy crises are rapidly increasing, which have destructive impacts on the industry in Pakistan. Biogas technology adoption is a challenge in a developing country like Pakistan. The government sector has taken initial steps to eliminate the energy crisis and promoted biogas plants. The primary objective of this study is to explore the satisfied and unsatisfied ratio of farmers who have adopted biogas plants in the country. The sample size was identified through the snowball sampling method. A total of 51 biogas adopters participated in this study. The structured questionnaires were used to collect data through online interviews. The results indicate that 34% of biogas plant respondents were satisfied with their plant feedback. The partially satisfied respondents were 24%, whereas 42% showed unsatisfaction. More than half (58%) of the respondents expressed that biogas plants are in good working conditions; however, 42% of biogas users were unrestrained for several causes. The findings of this study indicate that major maintenance and day-to-day operations of biogas plants are expensive due to lack of skilled operators, untrained or partially trained owners, and unavailability of technicians. The results suggest that the government needs to plan a clear policy, technical support with skilled technicians to biogas plant owners, all through an integrated and coherent way.
Prevalence and risk factors of irritable bowel syndrome in Irkutsk
Authors: Tsukanov V. V. , Vasyutin A. V. , Onuchina E. V. , Petrun’ko I. L. , Kasparov E. V. , Tonkikh Ju. L. 
Published: October 2021

Introduction. The study of the problem of irritable bowel syndrome (IBS) in recent years has been very dynamic. In the Rome IV criteria, new criteria for the diagnosis of this pathology were proposed. Along with the existence of ethnic and geographic differ­ences, this has led to an increase in the activity of studies on the prevalence of IBS.Aim. To study the prevalence and risk factors of irritable bowel syndrome in Irkutsk.Materials and methods. A single-stage observational non-randomized study was performed on the basis of three medical institu­tions in Irkutsk. Interviewing and clinical examination were performed in 1 529 people: 724 men and 805 women, average age 51.0 years. The questionnaire contained questions to determine the presence of alarm symptoms. The diagnosis of IBS was based on the Rome IV criteria. IBS with a predominance of diarrhea, IBS with a predominance of constipation and mixed and undiffer­entiated IBS were distinguished. Taking into account the position of the Rome IV criteria and the recommendations of the American College of Gastroenterology (2021), we used a positive diagnosis of IBS in our study and did not perform an instrumental examination of patients.Results. The prevalence of IBS was 12.3%. Among the subtypes of IBS, IBS prevailed with a predominance of constipation (preva­lence 5.7%) and IBS of mixed and undifferentiated type (prevalence 4.6%). Risk factors for IBS were female sex (OR = 0.73; CI 0.53-0.99; p = 0.05), age over 50 years (OR = 0.66; CI 0.48-0.90; p = 0.01) and obesity (OR = 0.46; CI 0.31-0.69; p < 0.001). Risk factors for IBS with a predominance of constipation were female sex (OR = 0.46; CI 0.29-0.73; p = 0.001), age over 50 years (OR = 0.46; CI 0.29-0.73; p = 0.001) and obesity (OR = 0.41; CI 0.23-0.72; p = 0.002).Conclusions. In general, our results are consistent with data from other regions of the world. It should be emphasized that the prevalence of IBS in Irkutsk is quite high, which requires careful attention to this problem.
Efficacy and safety of tofacitinib in moderate and severe ulcerative colitis in real clinical practice: three years of observation
Authors: Knyazev O. V. , Kagramanova A. V. , Lishchinskaya A. A. , Li I. A. , Podolskaya D. V. , Shkurko T. V. , Nanaeva B. A. , Aleksandrov T. L. , Baranova T. A. , Tishaeva I. A. , Zvyaglova M. Yu. , Parfenov A. I. 
Published: October 2021

Introduction. Tofacitinib is the first member of a new class of targeted synthetic anti-inflammatory drugs for the treatment of ulcerative colitis (UC). The article presents a three-year Russian experience of tofacitinib use for the treatment of moderate and severe UC.Aim of the study. To evaluate the efficacy and safety of tofacitinib therapy in real clinical practice in moderate to severe UC patients during three years of follow-up. Methods. The study included 56 patients with UC who had moderate (60.7%) and severe (35.8%) states of disease, the total lesion was diagnosed in 67.8%, and extraintestinal manifestations in 57.1% of patients. Early achievement of clinical response, clinical and endoscopic, corticosteroid-free remission, and safety were evaluated.Results. Early response to tofacitinib therapy was obtained in 47 (83.9%) patients. Clinical remission was achieved in 36 (64.3%) at week 8 of therapy and clinical response was achieved in 13 (23.2%) patients. The majority of patients who achieved clinical remission at weeks 8 and 12 achieved healing of colon mucosa at week 24. Clinical and endoscopic remission rates after 24 weeks – 44 (78.6%) patients, clinical response in 7 (12.5%) patients, 5 (8.9%) did not respond to TFCB therapy. Corticosteroidfree remission was 77.6%. After 2 years of tofacitinib therapy, remission of UC was maintained in 46 (82.1%). After 36 months, remission of UC was maintained in 45 (80.3%) of the 56 patients who had been started on tofacitinib therapy. The cumulative effect of survival in the treatment of tofacitinib in UC was 87.5% after 6 months and persisted for one year, 82.1% after 2 years, and 80.3% after 3 years.Conclusions. The administration of tofacitinib in UC is effective in achieving rapid clinical response, clinical remission, and mucosal healing in patients who do not respond well to biological therapy.
Clinical and pharmacological approaches to the management of exocrine pancreatic insufficiency in chronic pancreatitis
Authors: Drozdov V. N. , Shikh E. V. , Astapovskiy A. A. , Kotlyachkova Yu. V. , Dobrovolskaya L. E. , Starodubtsev A. K. , Komissarenko I. A. , Serebrova S. Y. 
Published: October 2021

Chronic pancreatitis is a multifactorial disease in which repeated episodes of inflammation of the pancreas contribute to the development of fibrous tissue, leading to chronic pain, as well as exocrine and endocrine insufficiency. The incidence and prevalence of chronic pancreatitis in the world are growing, as evidenced by current statistics. In addition, the annual costs associated with the treatment of exocrine and endocrine insufficiency are also increasing. In the United States alone, the annual cost of treating these complications is $ 75.1 million. Exocrine insufficiency is one of the most frequent complications, which is characterized by a deficiency of pancreatic enzymes, leading to the development of malabsorption syndrome (impaired absorption of nutrients, vitamins and minerals). Due to the increased incidence and deterioration of the quality of life associated with this condition, the goal of treatment is to compensate for the deficiency of exocrine enzymes with oral pancreatic enzyme replacement therapy. The core of this therapy is to deliver activated, unbroken enzymes directly to the small intestine during a meal. Many studies have shown that prescribing enzyme replacement therapy improves symptoms associated with exocrine insufficiency, reduces the progression of osteopenia, and improves survival in such patients. The use of pancreatin contributes to the correction of exocrine insufficiency in patients with chronic pancreatitis. The data presented in the article indicate that the drug is a safe and effective agent, meets all modern standards and requirements, and can be used to correct enzymatic pancreatic insufficiency.
Genetic predictors and pathophysiological features of non-alcoholic fat liver disease
Authors: Smirnova O. V. , Moskalenko O. L. , Kasparov E. V. , Kasparova, I. E. 
Published: October 2021

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in highly developed countries. The risk of developing NAFLD and associated complications varies greatly among people of different nationalities and is determined by environmental and genetic factors. Genome-wide studies have revealed strong and reproducible associations between gene variations such as PNPLA3, TM6SF2, MBOAT7, GCKR, HSD17B1, and NAFLD. In this article, we consider the influence of genes and environmental factors on the pathophysiological features of NAFLD. The use of a sufficient population sample with the analysis of SNP arrays and the use of sequencing methods (exome and genome as a whole) will lead to the discovery of additional genetic variants, will inevitably improve the understanding of the pathogenesis of NAFLD, and will allow the development of a technology for personalized risk in assessing the disease in a patient. The aim of our study was to study the genetic predictors of NAFLD based on literature data with the interpretation of the studies. There is now strong evidence that specific variants of genetic risk have a large effect on NAFLD, and their effect is comparable to that of major metabolic risk factors such as obesity and type 2 diabetes. The increased risk extends to the onset and progression of the entire spectrum of NAFLD manifestations, including overall mortality due to liver disease. Currently, individual genetic variants do not allow the creation of a personalized risk profile; therefore, the most expedient approach today is the development of polygenic risk assessments. The number of genetic loci associated with the prevalence and outcome of NAFLD remains limited. The use of a sufficient population sample with the analysis of SNP arrays and the use of sequencing methods (exome and genome as a whole) will lead to the discovery of additional genetic variants and will inevitably improve the understanding of the pathogenesis of NAFLD and will allow the development of a technology for personalized risk in the assessment of the disease.
Conducta prosocial asociada al bienestar en adolescentes
Authors: González-González Alejandro , Betancourt Ocampo Diana 
Published: October 2021

Introducción: a partir de la perspectiva del desarrollo positivo, la búsqueda del bienestar adquiere gran relevancia, ya que se sugiere que el ser humano estará en búsqueda constante del bienestar a través de las diferentes etapas de su vida. Este constructo se ha estudiado desde dos aproximaciones: desde la visión del bienestar psicológico y desde la visión del bienestar subjetivo. La literatura sugiere que las tendencias de contribución y ayuda hacia las personas que nos rodean favorecen el estado de bienestar y desarrollo saludable, por lo que algunos autores indican que las conductas prosociales deben favorecerse, en especial en la etapa de la adolescencia, para promover un adecuado desarrollo de los individuos.
Método: se realizó un estudio no experimental, transversal, con alcance descriptivo y correlacional, cuyo objetivo fue analizar el impacto que tiene la conducta prosocial en el bienestar, tanto psicológico como subjetivo, en población adolescente de México. Para esto, se contó con una muestra no probabilística por conveniencia de 803 adolescentes, con una media de edad de 14.87 años (49.1 % fueron hombres y 50.9 % mujeres). Se utilizó el Instrumento de Tendencias Prosociales, que consta de tres dimensiones: 1) ayuda emocional; 1) reconocimiento; y 3) altruismo. Además, se empleó la escala de Bienestar Psicológico de González-Fuentes (2013), que se conforma de siete dimensiones: 1) propósito de vida; 2) rechazo personal; 3) control personal; 4) planeación al futuro; 5) autoaceptación; 6) relaciones positivas con otros; y 7) crecimiento personal. También se utilizó la escala adaptada para población mexicana de Satisfacción de vida de Dienner, a fin de valorar el bienestar subjetivo. Todos los instrumentos empleados han sido utilizados previamente en población adolescente en México.
Resultados: se realizaron análisis de correlación de Pearson para determinar la relación entre las dimensiones de la conducta prosocial con las dimensiones del bienestar psicológico, así como con el bienestar subjetivo. Los resultados de estos análisis mostraron relaciones significativas en las tres dimensiones de la conducta prosocial (ayuda emocional, reconocimiento y altruismo) con la mayoría de las dimensiones del bienestar psicológico. Además, se encontraron correlaciones significativas entre la conducta prosocial con el bienestar subjetivo. Para analizar el efecto de la conducta prosocial sobre las dimensiones de bienestar psicológico y subjetivo se realizaron análisis de regresión lineal múltiple, paso por paso, las cuales mostraron que las dimensiones de conducta prosocial fueron variables predictoras tanto del bienestar subjetivo como del psicológico, con porcentajes de varianza del 7 % al 24 %.
Discusión: se discuten los datos a la luz de la perspectiva del desarrollo positivo, donde se plantea que los adolescentes son fuente de recursos y posibilidades más que de conflictos, por lo que se sugiere promover conductas prosociales en ellos para favorecer su desarrollo.
Removal of metronidazole antibiotic from aqueous solution by ammonia-modified activated carbon: adsorption isotherm and kinetic study
Authors: Ahmadfazeli Ali , Poureshgh Yousef , Rashtbari Yousef , Akbari Hamed , Pourali Peyman , Adibzadeh Amir 
Published: October 2021

Abstract
This article was aimed at investigating the removal of metronidazole (MNZ) from aquatic solutions by modified activated carbon (MAC) with amine groups. The effect of various parameters on the adsorption rate such as the initial pH, adsorbent dose and initial concentration of MNZ and contact time were scrutinized. MAC was characterized by Fourier transform infrared spectroscopy and Brunauer–Emmett–Teller techniques. The obtained results illustrated that under the optimum conditions (pH = 3, contact time = 50 min, initial MNZ concentration = 5 mg/L and MAC dose = 0.5 g/L), the maximum adsorption efficiency was 95%. Furthermore, the kinetic studies indicated the applicability of the pseudo-second-order kinetic model, whereas the adsorption isotherm fitted well with the Freundlich model (0.996), and the maximum adsorption capacity was 66.22 mg/g. The SBET and the total pure volume of MAC were 706.92 m2/g and 0.532 cm3/g, respectively. Also, the regeneration tests demonstrated that MAC had good stability after five cycles (73%). It can be concluded that MAC, as an effective adsorbent, has a high ability to remove MNZ from aqueous solutions.
Detection of methanotrophic microorganisms in sludge and sediment samples from sewage treatment systems
Authors: Siniscalchi L. A. B. , Siqueira J. C. , Batista A. M. M. , Araújo J. C. 
Published: October 2021

Abstract
This study investigated various groups of methanotrophic microorganisms, including the anaerobic methane-oxidizing archaea (ANME) group, aerobic methanotrophic bacteria, and bacteria of the phylum NC10 (Candidatus Methylomirabilis oxyfera). The polymerase chain reaction (PCR) technique was employed with specific primers for the pmoA gene from the aerobic methanotrophic and M. Oxyfera methanotrophic denitrifying (NC10 phylum) and for the anaerobic methanotrophic archaea 16S rRNA gene (ANME-1 and ANME-2). Sludge and sediment samples were analyzed from different sewage treatment systems installed at the Sanitation Research and Training Center (CePTS) at the Arrudas wastewater treatment plant (Arrudas WWTP), in Belo Horizonte, Brazil. ANME was shown to be present in sludges from the upflow anaerobic sludge blanket (UASB) reactor and activated sludge system, and in sediments from the polishing pond and wetlands. On the other hand, aerobic methanotrophic bacteria were detected only in the polishing pond samples, while no methanotrophic denitrifiers of the M. oxyfera genre were detected at all. Besides investigating and detecting different groups of methanotrophs in the treatment systems, the study provided support for another in which samples from the systems analyzed were selected for use as inoculum for methane anaerobic oxidation potential experiments and methanotrophic microorganism enrichment.
Microglial Activation in the Neurodevelopment: A Narrative Review
Authors: de Moura Airam Barbosa , Abitante Morgana Sonza , Silva Ritele Hernandez , Quevedo João , Réus Gislaine Zilli 
Published: October 2021

Abstract:
Microglia are immune cells found in the central nervous system (CNS)
involved in infection combat and cellular debris clean. These glial cells are involved in
synaptogenesis during brain development by their interactions with neurons and other
glial cells. These relations are associated with the secretion of signaling molecules, such
as chemokines and neurotrophic factors. Microglia cells influence synapsis and neuron
morphology during different phases of development. Also, other systems, for example,
gut microbiota, indirectly affect microglial functions and morphology. Several factors that
can occur in different development periods, including intrauterine through adult life,
could impact microglia. Impairment in these cells could be associated with the
development of some psychiatric conditions, such as schizophrenia, autistic spectrum
disorder (ASD), and depression. This review focuses on describing microglia functions in
the maintenance of CNS and how they are associated with other systems, as the gutmicrobiota
brain axis and environmental stressors, such as stress, maternal deprivation,
sleep deprivation, immune activation, and ethanol exposure, that can influence the
function of the microglia during neurodevelopment.
Combining Daily Electricity Forecasts Based on DBSCAN and Stacking Fusion
Authors: Lv Zhixing , Cheng Sijin , Wang Yi , Wang Shenzheng , Li Xinyi , Ran Ran 
Published: October 2021

Background:
Modern upgrades of power grids and a rapidly expanding economy complexify
the uncertainties of electricity demand.

Objective:
The objective of the study is to have a more precise prediction on the demand side, which is
beneficial in affirming the stable operation of the power system.

Methods:
This paper presents a combined electricity forecasting method based on the users clustering
and stacking ensemble learning to mine underlying properties of different individual consumers. The
preprocessed electricity consumption profiles are inputted into the DBSCAN clustering algorithm to
obtain the clusters. The alternative models are tailored for different clusters in the stacking fusion
framework for training and testing.

Result:
Experimental results on the operating data of Shandong Power Grid show that the proposed
method has higher prediction accuracy and better generalization ability.

Conclusion:
The framework is of great significance for improving the level of power supply service.