bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wavelet and cross correlation analysis on some climatology parameters of Nepal
Authors: Tiwari Babu Ram , Xu Jiyao , Adhikari Binod , Chapagain Narayan Prasad 
Published: June 2021

This study has been performed to understand the relationship between sunspot numbers (SSN) with climatology related parameters like temperature and rainfall from 1901 to 2016. The spectral characteristics of sunspot numbers, temperature and rainfall have been observed using continuous wavelet transform. Cross-correlation analyses were also performed to find any relation among temperature, rainfall, and sunspot numbers. The 9–11 year periodicity of sunspot numbers confirmed by wavelet transform in annual scale. The periodicity of high-frequency signals is identified between 4 to 11 years whereas the low frequencies signal is found throughout the periods of observation for temperature. Similarly, it is clear that there is more concentration of power between 8–16 years for rainfall. Cross-correlation analysis shows that the sunspot numbers is highly correlated with rainfall and temperature (correlation coefficient ~ 0.8054). The time lag relationship resulted in the almost simultaneous linear relationship between the temperature, rainfall, and the SSN tendency. The development of convective motions over the subtropics might be affected by the time rate of change of SSN combined with the surface temperature changes of diverse time scales. The convective motions were mostly controlled by the available amount of water vapor and the stability of the atmosphere that had a strong connection with the heat capacity of the concerned region. To produce more authentic findings for policy implications, further comprehensive and appropriate research can be undertaken and implemented in this very important field.
BIBECHANA 18 (2) (2021) 105-115
A rare case of lateral pontine syndrome-Marie Foix syndrome
Authors: Regmi Pradeep Raj , Amatya Isha 
Published: June 2021

Lateral pontine syndrome or Marie Foix Alajouanine syndrome refers to the brainstem stroke syndrome involving lateral pons due to the infarction in the distribution of the anterior inferior cerebellar artery. It involves the lateral inferior part of the pons, middle cerebellar peduncle, and floccular region. Computed Tomography (CT) is less sensitive in brainstem infarction than Magnetic Resonance Imaging (MRI). With the introduction of MRI, it is possible to precisely locate the brainstem infarcts. We present a case with a typical clinical picture of brainstem stroke with radiological findings consistent with the lateral pontine syndrome. Proper correlation with the clinical picture and radiological findings is important for the diagnosis of brainstem infarctions.
The system of internal quality assurance of educational activities and the quality of higher education: from the experience of the Faculty of Social and Psychological Education of Uman State Pedagogical University named after Pavel Tychyna
Authors: Kravchenko Oksana , Karpych Iryna 
Published: June 2021

The article highlights the experience of internal quality assurance of educational activities and the quality of higher education of the Faculty of Social and Psychological Education of Uman State Pedagogical University named after Pavel Tychyna. The current system of internal quality assurance of educational activity and quality of higher education at the Faculty of Social and Psychological Education of Uman State Pedagogical University named after Pavel Tychyna is analyzed.
It is established that the internal quality assurance of educational activities and the quality of higher education at the faculty has a systemic nature and is carried out in certain areas that are logically and consistently interconnected, namely: periodic review and updating of educational programs (updating educational programs; preparation of new and improvement of current curricula, monitoring the quality of working programs of academic disciplines, development of syllabuses, informing students about the disciplines of free choice, analysis of the availability of educational and methodological and information support); assessment of applicants for higher education (assessment of students, periodic surveys of participants in the educational process); promoting the principles of academic integrity; monitoring the quality of teaching staff (analysis of the timeliness of internships and in-service training by teachers, monitoring the quality of training sessions by teachers, analysis of compliance with the licensing conditions of staffing); ensuring the availability of necessary resources; ensuring publicity of information.
Ensuring the quality of educational activities and the quality of higher education at the Faculty of Social and Psychological Education is ensured by a holistic systematic interaction of all participants in the educational process, faculty and university in the implementation of appropriate internal measures and procedures aimed at improving the quality of education.
Pengaruh Supeltas Terhadap Tingkat Pelayanan Simpang Jalan Trans Kalimantan-Komplek Griya Permata
Authors: Hawinuti Riska 
Published: June 2021

The appearanced of the peoples called “Supeltas" (Sukarelawan Pengatur lalulintas=Traffic Regulatory Volunteers) occurs along with the increasing number of queue vehicles that will turn towards the road. Supeltas itself is persons (not official from the government) who manage traffic flow expecting voluntari giffts from people passing through the road. Often, these activities broke the road rules and exacerbate existing congestion. The purpose of this study was to compare the performance of unsignalizes intersections between the existing and non-existent of "Supeltas" it self.
The requirement data needed are the primary data in the form of geometric data, traffic conditions, traffic and environmental conditions data, and secondary data in the form of population and location map. Traffic data collection is done using manual calculation for 2 periods on Tuesday, Wednesday and Thursday at 06.30-08.00 in the morning, noon 12.00-14.00 and afternoon at 16.30-18.30 WITA for each condition of rush hours. The calculation refers to MKJI 1997.
The calculation results obtained by the degree of saturation (DS) without the "Supeltas" amounting to 1,816 and with the provision "Supeltas" of 1,525, this DS value exceeds the IHMC ( Indonesian Highway Manual Capacity) previsions 0,75. It can be concluded that the existence of "Supeltas" made a positive impact to reduce the number of DS where it decreased 16.02%.
Tinjauan Nilai Permeabilitas Tanah Tanggul Canal Blocking
Authors: Arifin Muhammad Amad , Fathurrozie Fathurrozie 
Published: June 2021

Air sangat berpengaruh pada sifat-sifat teknis tanah dan juga air berperan sangat penting dalam masalah-masalah teknis yang berhubungan dengan tanah yaitu permeabilitas. Permeabilitas tanah yaitu kecepatan air yang menembus tanah pada periode tertentu dan dinyatakan dalam cm/jam. Nilai permeabilitas sangat penting dalam menentukan penggunaan dan pengelolaan praktis tanah. Koefisien permeabilitas tanah memiliki nilai yang berbeda untuk berbagai jenis tanah. Ada dua macam alat untuk menentukan nilai permeabilitas, yaitu constant head permeameter dan falling head permeameter.
Lokasi penelitian tanggul canal blocking berada di Hutan Lindung Liang Anggang yang terletak di Kecamatan Liang Anggang, Kota Banjarbaru, Provinsi Kalimantan Selatan. Dimana tubuh tanggul canal blocking menggunakan tanah urugan setempat (tanah gambut) dijadikan tubuh tanggul canal blocking. Tugas Akhir ini menggunakan metode survei dan pengambilan data tanah pada kawasan tanggul canal blocking.
Bila dilihat nilai permeabilitasnya pada tubuh tanggul yang didapat, termasuk kelas sangat rendah yaitu kurang < 0,125 cm/jam. Jadi penggunaan tanah urugan setempat untuk dijadikan tubuh tanggul sudah cukup efektif .
Water is very influential on the technical properties of soil and also water plays a very important role in the technical problems related to soil, namely permeability. Soil permeability is the speed of water that penetrates the soil in a certain period and is expressed in cm / hour. Permeability values ​​are very important in determining the practical use and management of land. The soil permeability coefficient has different values ​​for various types of soil. There are two types of tools for determining permeability values, namely constant permeability head and permeability falling head.
The research location of the canal blocking dikes is in the Liang Anggang Protected Forest located in Liang Anggang District, Banjarbaru City, South Kalimantan Province. Where the canal blocking embankment body uses local soil (peat soil) as a canal blocking embankment body. This Final Project uses a survey and retrieval of soil data in the canal blocking embankment area.
If you see the permeability value on the embankment body obtained, including the class is very low, which is less than 0.125 cm / hour. So the use of local land to be used for embankment is quite effective.
Hubungan Kejadian Asfiksia Neonatorum dengan Gangguan Fungsi Koklea pada Neonatus
Authors: Shinta Nindya , Novira Afita 
Published: June 2021

Gangguan pendengaran pada masa bayi dapat menyebabkan gangguan bicara, berbahasa, kognitif, masalah sosial, dan emosional sehingga dapat menurunkan kualitas hidup seseorang. The Joint Committee of Infants Hearing (JCIH) tahun 2007 menyatakan asfiksia neonatorum sebagai salah satu faktor risiko gangguan pendengaran pada neonatus. Hipoksia pada bayi dengan kondisi asfiksia dapat menyebabkan kerusakan pada outer hair cell (OHC) dan edema stria vaskularis sehingga mengganggu fungsi koklea. Kerusakan outer hair cell dapat dinilai dengan pemeriksaan Otoacoustic Emission (OAE). Tujuan penelitian ini untuk menganalisis hubungan kejadian asfiksia neonatorum terhadap gangguan fungsi koklea pada neonatus. Penelitian ini merupakan penelitian analitik observasional dengan metode cross sectional. Penelitian ini dilakukan di RSD dr. Soebandi dan RSU Kaliwates Jember pada 29 November 2019 - 8 Januari 2020 di Ruang Perinatologi. Pengambilan data menggunakan consecutive sampling. Analisis data dilakukan menggunakan Chi-square test dengan p-value < 0,05. Dari 16 neonatus, 8 neonatus memiliki riwayat asfiksia derajat sedang dan 8 neonatus lainnya tidak memiliki riwayat asfiksia. Gangguan fungsi koklea ditemukan pada 3 (37,5%) neonatus dengan asfiksia derajat sedang dan 6 (75%) neonatus tanpa riwayat asfiksia. Hasil penelitian menunjukkan tidak terdapat hubungan antara asfiksia neonatorum derajat sedang dengan gangguan fungsi koklea (p=0,142).
Hubungan Perilaku Sedentari terhadap Nilai Tekanan Darah pada Mahasiswa
Authors: Destira Fellycia , Mariani Mariani 
Published: June 2021

Proporsi penduduk Indonesia dengan perilaku sedentari lebih dari sama dengan 6 jam perhari adalah 24,1%. Salah satu dampak negatif yang dapat ditimbulkan oleh perilaku sedentari adalah tekanan darah tinggi. Hal ini dapat terjadi karena perilaku sedentari dapat memberikan efek sistemik pada vaskular, metabolik dan otonom. Tujuan penelitian ini untuk mengetahui hubungan antara perilaku sedentari dengan nilai tekanan darah. Penelitian ini merupakan penelitian analitik dengan pendekatan studi potong lintang yang dilaksanakan pada bulan Juli 2019 hingga September 2019 terhadap 107 responden dengan rentang usia 16 hingga 22 tahun. Data jenis kelamin, perilaku sedentari , dan nilai tekanan darah yang didapat melalui kusioner Bouchard’s Physical Activity Record dan sphygmomanometer dianalisis menggunakan metode chi-square. Sedangkan, data rerata durasi aktivitas fisik sedentari dan nilai tekanan darah dianalisis menggunakan metode uji T tidak berpasangan. Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara jenis kelamin dengan tekanan darah (p = 0,000), aktivitas fisik sedentari seperti menonton TV (p = 0,001), bermain laptop (p = 0,000), duduk bermain Hp (p = 0,001), duduk berkendara (p = 0,004), belajar (p = 0,038), menyetir (p = 0,003), dan hubungan yang bermakna antara perilaku sedentari dengan nilai tekanan darah (p = 0,001) dengan OR = 6,981. Kesimpulan penelitian ini meunjukkan bahwa perilaku sedentari merupakan faktor risiko terjadinya peningkatan tekanan darah.
CRISPR-Cas9 Potential in Eradicating HIV Latent Reservoir as The Up-to-date Therapy For HIV-1
Authors: Salim Jesica Putri , Anggraini Friska , Safa Nabila Putri  , Maritska Ziske 
Published: June 2021

According to the Ministry of Health in Indonesia, in 2018, there are about 640 thousand cases of people with HIV within the death rate of 38 thousand people. This number grows annually, in fact, according to WHO, there are approximately 38 million people who are diagnosed with HIV in the world in 2019. Thus, HIV-AIDS is a dangerous health problem and needs to be taken care of as soon as possible. HIV (Human Immunodeficiency Virus) is a retrovirus that got its name from the infecting immune cells in the human body. There are two types of HIV, named HIV-1 and HIV-2. Both have the same basic gene arrangement, transmission process, intracellular replication lane, and both cause AIDS. The differences between them are the HIV-1 spreads globally, while HIV-2 locally happens in West Africa. Currently, ART (Antiretroviral Therapy) is the most commonly used method of treatment for HIV-1. Treatment for HIV-1 with ART is effective in controlling HIV-1 virus replication but has not been able to completely eradicate the latent viral reservoir. In the past few years, it is known that there is a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) method that can modify genes (DNA) in the body of an organism. However, apart from its potential in handling HIV-1, there are still obstacles in the mechanism.
DEMAND-SIDE MANAGEMENT FOR ENERGY PRODUCTION USING MICRO COMBINED HEAT AND POWER SYSTEM – A REVIEW
Authors: Abdulsalam Hassan , Nuhu Ibrahim 
Published: June 2021

World development increased dramatically ever since the Industrial Revolution, in particular after second world war (WWII), which drove the rise of energy consumption. Thus, energy consumption in the World has been growing continuously in the past 50 years. Using micro Combined Heat and Power (mCHP) allows energy scheduling and demand-side management depending on different variables which will benefit users and suppliers. Different researches have been conducted due to increasing interest from researchers to increase and optimise the advantages of energy scheduling. In addition to the mCHP system, optimisation process also includes distributed energy sources (solar panels) with electricity storage. On the demand side, various devices with different load profiles which can be controlled over time can be considered. This study therefore, being a desktop based one, sought to review the energy demand-side management as it applies to the use of mCHP in residential settings.
Nebulization Practice and use of Antibiotic in the Treatment of Childhood Asthma at the Rural Area
Authors: Alam MD Shafiul , Yasmeen B H Nazma , Md Benzamin - , Haq Nadia , Hasan Md Shariful 
Published: June 2021

Background : Management of childhood asthma is not optimum in our country especially at the community level.
Objectives : The study was conducted to see the nebulization practice in the management of moderate and sever acute asthma in children at the community level.
Methodology : This cross-sectional observational study was conducted in different private clinics and pharmacy of Daudkandi Upazila of Cumilla during the period of November 2017 to March 2018. Total 30 doctors’ diagnosed cases of acute exacerbation of moderate and severe asthma between 2-15 years of age were included in this study. Each patient’s treatment advice was followed up to see whether the use of nebulized Salbutamol and Antibiotic in the management of acute asthma was appropriate or not. All data were recorded in to a pretested proforma. Data were analyzed manually, and values were expressed as frequency and percentage.
Results : Among the cases 25 (83.33%) cases had moderate and 5 (16.67%) cases had severe exacerbation of asthma. For nebulization, salbutamol was used to all cases and ipratropium bromide was added to 11 (36.7%) cases. Nebulization frequency was as per national guideline but the ratio of salbutamol respiratory solution to normal saline was not appropriate in most of the cases. Antibiotic was given to all cases and among them parenteral Ceftriaxone was given to 22 (73.3%) cases.
Conclusion : Frequency of nebulization was appropriate but ratio of Salbutamol respiratory solution to normal saline was inappropriate. Antibiotic was given to all cases.
Northern International Medical College Journal Vol.11 (2) Jan 2020: 471-474
Long-Term Antithyroid Drug Treatment of Graves’ Disease in Children and Adolescents: A 20-Year Single-Center Experience
Authors: Song Ari , Kim Su Jin , Kim Min-Sun , Kim Jiyeon , Kim Insung , Bae Ga Young , Seo Eunseop , Cho Young Seok , Choi Joon Young , Cho Sung Yoon , Jin Dong-Kyu 
Published: June 2021

Background/purposeGraves’ disease (GD) is the most common cause of thyrotoxicosis in children and adolescents. There is some debate regarding the optimal treatment and predicting factors of remission or relapse in children and adolescents with GD. In this study, we report a retrospective study of 195 children and adolescents with GD treated at a single tertiary institution in Korea.MethodsThis study included children and adolescents with GD diagnosed before 19 years of age from January of 2000 to October of 2020. The diagnosis of GD was based on clinical features, high thyroxine (FT4), suppressed thyroid-stimulating hormone, and a positive titer of thyrotropin receptor antibodies. Remission was defined as maintenance of euthyroid status for more than six months after discontinuing antithyroid drug (ATD).ResultsA total of 195 patients with GD were included in this study. The mean age at diagnosis was 12.9 ± 3.2 years, and 162 patients (83.1%) were female. Among all 195 patients, five underwent thyroidectomy and three underwent radioactive iodine therapy. The mean duration of follow-up and ATD treatment were 5.9 ± 3.8 years and 4.7 ± 3.4 years, respectively. The cumulative remission rates were 3.3%, 19.6%, 34.1%, 43.5%, and 50.6% within 1, 3, 5, 7, and 10 years of starting ATD, respectively. FT4 level at diagnosis (P = 0.001) was predicting factors for remission [HR, 0.717 (95% CI, 0.591 – 0.870), P = 0.001]. Methimazole (MMI)-related adverse events (AEs) occurred in 11.3% of patients, the most common of which were rash and hematologic abnormalities. Of a total of 26 AEs, 19 (73.1%) occurred within the first month of taking MMI.ConclusionsIn this study, the cumulative remission rate increased according to the ATD treatment duration. Long-term MMI treatment is a useful treatment option before definite treatment in children and adolescents with GD.
A Competing Risk Analysis of Women Dying of Maternal, Infectious, or Non-Communicable Causes in the Kintampo Area of Ghana
Authors: Abubakari Sulemana Watara , Badasu Delali Margaret , Apraku Edward Anane , Amenga-Etego Seeba , Asante Kwaku Poku , Bawah Ayaga Agula , Owusu-Agyei Seth 
Published: June 2021

Background: Maternal, infectious, and non-communicable causes of death combinedly are a major health problem for women of reproductive age (WRA) in sub-Saharan Africa (SSA). Little is known about the relative risks of each of these causes of death in their combined form and their demographic impacts. The focus of studies on WRA has been on maternal health. The evolving demographic and health transitions in low- and middle-income countries (LMICs) suggest a need for a comprehensive approach to resolve health challenges of women beyond maternal causes.Methods: Deaths and person-years of exposure (PYE) were calculated by age for WRA within 15–49 years of age in the Kintampo Health and Demographic Surveillance System (KHDSS) area from January 2005 to December 2014. Causes of death were diagnosed using a standard verbal autopsy questionnaire and the 10th Revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10). Identified causes of death were categorized into three broad areas, namely, maternal, infectious, and non-communicable diseases. Multiple decrements and associated single decrement life table methods were used.Results: Averting any of the causes of death was seen to lead to improved life expectancy, but eliminating infectious causes of death leads to the highest number of years gained. Infectious causes of death affected all ages and the gains in life expectancy, assuming that these causes were eliminated, diminished with increasing age. The oldest age group, 45–49, had the greatest gain in reproductive-aged life expectancy (RALE) if maternal mortality was eliminated.Discussion: This study demonstrated the existence of a triple burden. Infectious causes of death are persistently high while deaths from non-communicable causes are rising and the level of maternal mortality is still unacceptably high. It recommends that attention should be given to all the causes of death among WRA.
Absolute Cardiovascular Disease Risk Is Associated With the Incidence of Non-amnestic Cognitive Impairment in Japanese Older Adults
Authors: Makino Keitaro , Lee Sangyoon , Bae Seongryu , Chiba Ippei , Harada Kenji , Katayama Osamu , Shinkai Yohei , Shimada Hiroyuki 
Published: June 2021

BackgroundThe estimated absolute cardiovascular disease (CVD) risk level is known to be a useful surrogate marker for future cognitive impairment; however, evidence regarding its predictive validity in terms of cognitive subtypes is limited. We aimed to examine subtype-dependent differences in the associations between absolute CVD risk and the incidence of cognitive impairment in a community-dwelling older Japanese cohort.Methods and ResultsThis study comprised 1,641 cognitively intact older Japanese participants without CVDs at baseline. We estimated absolute CVD risk using WHO region-specific risk estimation charts and included age, sex, diabetes mellitus, smoking, systolic blood pressure, and total cholesterol at baseline, and the CVD risk level was stratified into the three following risk categories: low (&lt;10%), moderate (10 to &lt;20%), and high (≥20%). Objective cognitive screening was performed using a multicomponent neurocognitive test at baseline and follow-up, and the incidence of cognitive impairment over 48 ± 2 months was determined. The incidence of cognitive impairment in low-, moderate-, and high-CVD risk participants was 1.2, 3.0, and 5.4%, respectively, for amnestic subtypes and 5.8, 10.1, and 14.0%, respectively, for non-amnestic subtypes. After adjusting for potential confounding factors, the absolute CVD risk level was significantly associated with non-amnestic impairment but not with amnestic impairment.ConclusionsThe absolute CVD risk estimated using region-specific risk estimation charts in old age is useful to predict incidence of cognitive impairment. Strategies to screen populations at risk of cognitive impairment and to prevent progression to dementia should be cognitive subtype-specific.