bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Grape Seeds (Vitis vinifera L.) and Mandarin Peels (Citrus reticulate L.) Extracts on the Cardiotoxicity Induced by Cyclophosphamide in Rats
Authors: Mohamed Hanan Kamal , Abd El-Fattah Hanaa Mostafa , Barakat Heba , A. Ahmed Kawkab , Mousa Galal Sahar 
Published: October 2021

Aims: The current study was developed to investigate the influence of grape seeds (GS) and mandarin peels (MP) extracts as powerful antioxidants on the cardiotoxicity induced by cyclophosphamide (CP) in rats.
Place of Study: Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University.
Methodology: Sixty adult male Sprague-Dawley rats were divided into 6 groups. Group (1): Rats were received distilled water daily orally for 6 weeks and injected interperitoneally (i.p) with saline (0.9 %) (2.5 ml / kg BW) as single dose at the end of the sixth week of experiment. Group (2): Rats were received distilled water orally and injected with single dose of cyclophosphamide which dissolved in saline (200 mg/kg BW. i.p.) at the end of the sixth week of experiment. Groups (3 and 4): Rats were received grape seeds extracts low and high doses (150 and 300 mg /kg BW), respectively daily orally for 6 weeks then injected with cyclophosphamide as group 2. Groups (5 and 6): Rats were received mandarin peels extracts low and high doses (150 and 300 mg /kg BW), respectively daily orally for 6 weeks then injected with cyclophosphamide as group 2.
Results: Our results documented that CP caused a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALK-P), creatine kinase (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK) enzymes activity and serum malondialdehyde (MDA) level. While total antioxidant capacity level (TAC) showed a significant decrease. On the other hand cardiac catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and cardiac β cell lymphoma (Bcl-2) level showed a significant decrease in CP group while cardiac p53, caspase-3 and DNA fragmentation levels showed a significant increase in CP intoxicated group. Also, some histopathological changes were observed in liver and heart tissues in CP group. Oral administration of GS and MP caused an ameliorative effect in oxidative and apoptotic biomarkers, liver and heart function enzymes activity with an improvement of histopathological changes in liver and heart tissues.
Conclusion: Our data proved that the protective effect of grape seeds and mandarin peels in cyclophosphamide intoxicated group may be due to their antioxidant, anti-inflammatory and anti- apoptotic properties.
Effect of Organic Nutrients and Growth Regulators on Yield and Quality of Goldenrod (Solidago canadensis L)
Authors: Angel Y. , Vignesh Kumar A. , Abinaya S. 
Published: October 2021

An Investigation was conducted to study the effect of organic inputs and growth regulators on yield and quality of goldenrod (Solidago canadensis) was conducted at the floricultural unit, Department of Horticulture, Faculty of Agriculture, Annamalai University during 2018. The experiment was laid out in randomized block design with twelve treatments, various organic inputs and growth regulators including panchagavya @ 3%, vermiwash 1:5 dilutions, humic acid @ 0.2%, GA3 @ 250 ppm, NAA @ 250 ppm were applied. The yield and quality characters were studied at different stages. The observations recorded viz., yield of flower stalks/ha, days to first flowering, length of flower stalks and weight of individual flower stalks. The results revealed that plants treated with NAA @ 250 ppm + panchagavya @ 3% (T9) was observed highest flower stalk yield (1140.02 flower stalks/ha), No. of flower stalks/plant (24.48), weight of individual flower stalks, days to first flowering. Considering the overall performance, it was found that the plants treated with NAA @ 250ppm + Panchagavya @ 3% recorded better performance with regard to growth, yield and quality characters.
Microbiological Quality Assessment and Identification of Antibiotic Resistant Bacteria at Different Stages of the Milk Supply Chain in Dhaka City of Bangladesh
Authors: Nowar Abira , Ismail Ila , Binte Iqbal Raisa , Rumi Alim Sharmin 
Published: October 2021

Aims: Milk works as an excellent medium for bacterial growth and can turn into a fatal source of food borne diseases when consumed without pasteurization. This study was carried out to examine the microbiological quality of milk from three different points of milk supply chain to investigate whether the dairy stakeholders are maintaining the consumer safety or not.
Study Design: A cross sectional study
Place and Duration: The study took place at the Food Microbiology lab of Institute of Nutrition and Food Science, University of Dhaka from November 2019 to February 2020.
Methodology: A total of 60 samples were studied including raw milk from collection centers, unpackaged pasteurized milk from processing plants and packaged pasteurized milks from retail shops. After carrying out the microbiological analysis the samples were examined for determining the total bacterial count (TBC) and total coliform count (TCC). Antibiotic susceptibility test was done using disk diffusion assay and detection of virulent gene in Salmonella spp. was done by Polymerase Chain Reaction (PCR) using specific invA primer.
Results: The results revealed that all raw milk samples were substandard in terms of TBC and TCC and pasteurized milks from processing plants maintained the standard quality. Importantly, packaged pasteurized milk samples from retail shops had high TBC (>4.0× 104 CFU/mL) and TCC (1.2×103 CFU/mL) containing Pseudomonas, Micrococcus, Streptococcus, Salmonella, Proteus, Staphylococcus, Bacillus and E. coli. Bacteria like Salmonella (75%), Proteus (62.5%) and Vibrio (62.5%) possessed high Multiple Antibiotic Resistance (MAR) index and showed resistance towards antibiotics namely Ampicillin, Amoxicillin, Erythromycin and Colistin. Through further molecular analysis we detected invA virulent gene one of the Salmonella isolates which was collected from the pasteurized milk samples of the retail shops.
Conclusion: High bacterial load in raw milk and packaged pasteurized milk indicate that the milk we consume is substandard in microbiological quality. Precautionary measurements and careful processing of milk may reduce the prevalence of microbiological contamination in the milk supply chain.
Antioxidant, Cytotoxic and larvicidal Potential in Oxalis latifolia Kunth. Methanolic Leaf Extract
Authors: Krishnan R. Gopi , Murugesh S. 
Published: October 2021

Aims: The current work was analyzed in antioxidants, cytotoxicity and larvicidal potential were examined for O. latifolia methanolic leaf extract.
Methodology: Antioxidant assasy for Hydroxyl radical (H2O2). Cytotoxicity potential was studied against colon (HT-29). Culex quinquefasciatus (IVth instar) larvae was used for larvicidal test.
Results: Antioxidant and cytotoxicity exhibits significant activities with IC50 value of 442.94 µg/mL and also the cytotoxicity activity IC50 values of 50.00μg/mL for HT-29. Larval mortality against the larvae of Cx. quinquefasciatus showed best activity with LC50 09.50mg/L and LC90 28.72 mg/L.
Conclusion: Thus, this study proved that methanolic leaf extracts of O. latifolia have significant biological activities. Hence, it can be used for pharmacetutical applications.
Comparative Evaluation of Antipyretic Activity of an Ayurvedic Herbo-mineral Formulation Dhatryadi Churna and Its Modified Dosage form in Albino Wistar Rats
Authors: Rathi Bharat , Shelke Sanket , Rathi Renu , Awari Devyani 
Published: October 2021

Introduction: Experimental studies are essential and expected part of a new drug development. The studies are conducted to know about the toxic effects (if any), produced by the drug & to access safety of the drug. Studies also help to ascertain the efficacy of the drug & measures to be taken so as to curtail the toxic effects.
Aim & Objective: Study was aimed to do comparative evaluation of antipyretic activity of an Ayurvedic herbo-mineral formulation Dhatryadi Churna and its modified dosage form in experimental albino rats.
Materials and Methods: Present study was carried out at Animal house attached with the Institute. 24 healthy Albino wistar rats of either sex weighing 180-200 gm were randomly selected and divided into 4 groups. Pyrexia was induced in rat by subcutaneous injection of 10 mL/kg b.w. of a 20% aqueous suspension of brewer's yeast. The trial drug Dhatryadi Churna and Dhatryadi Vati administered orally in the form of suspension to the albino rats.
Observation and Results: The present result shows that the Dhatryadi Churna (DC) and Dhatryadi Vati (DV) have a significant antipyretic effect in yeast induced pyrexia in rats. Hematological parameters were found to be within the normal biological and laboratory limits on comparison with the values of the control group.
Conclusion: Dhatryadi churna and Dhatryadi Vati does not show significant adverse effects on the blood, blood cells, and target organs at the doses used and can be safely used in human being.
Application of Elements of Quality by Design to Development and Optimization of HPLC Method for Fingolimod
Authors: Ansari Siddique Akber , Deshpande Mrinmayee , Sangshetti Jaiprakash N. , Ahmed Sarfaraz , Ansari Irfan Aamer 
Published: October 2021

Purpose: A HPLC method for Fingolimod was developed using a Quality by Design concept. QbD has gained importance in recent times due to regulatory requirements. Actual study was started after determination of target profile and qualification of instrument.
Methods: Separation was carried on a Grace C-8 column (4.6 x 250 mm, 5-μm particle size).The composition of mobile phase was methanol and 20 mM ammonium formate buffer of pH5.8 in gradient mode HPLC method development is affected by critical factors like pH, flow rate and mobile phase composition.
Results: To study the effects of these three factors on USP tailing, Box Behnken optimization model was applied. Desirability of the model was set at Tailing less than 1.2.Analysis of results was done using surface diagrams. Verification of Software generated results was done by taking six replicates of the run. Thus developed and optimised method was Finally validated as per ICH guideline.
Conclusion: A Quality by Design approach has been successfully utilised in method development of the Fingolimod in bulk. All key aspect of QbD were tried to be implemented in said study.
Systematic approach was utilized for method development which includes beginning with determination of target profile characteristics, instrument qualification, risk assessment, design of experiment and validation.
Three factors i.e. Ph, flow rate and methanol concentration were analysed for their effect on USP tailing as a responce. Interaction and quadratic effect of the factors were studied with least possible runs by using Box Behnken model. Response surface diagrams and contour plots were studied for coming to conclusion which factors are affecting response and their limits were recorded. Optimum run condition was obtained; Replicates of run having optimized condition were taken to confirm the predicted response with actual response.
Anti-Inflammatory Drugs and Usage of Them among Saudi Population: Knowledge and Attitude Assessment
Authors: Algamdi Khalid A. , Aldajam Muteb A. , Alanazi Fadiyah D. , Rajab Alya M. , Alshammari Rasha S. , Almohaimeed Muhannad A. , Alzahrani Khames T. 
Published: October 2021

Aims: To measure knowledge and attitude among the Saudi population about non-steroidal inflammatory drugs.
Study Design: This is an observational cross-sectional study.
Place and Duration of Study: Conducted in the north region of Saudi Arabia between June 2020 and July 2021.
Methodology: The data collection done by using an electronic questionnaire. Total sample size of 1018 participants, aged between 15-60, Female and Male, agree to participate. Each person meeting the inclusion criteria was provided informed consent, explaining the study aim, and ensuring the confidentiality of information. Data were obtained by filling out the designed Questionnaire.
Results: A total of 1018 participants completed the survey questionnaire. About 81% of the study participants stated that they have a history of analgesic use without physician prescription in the past six months. More than 30% of participants stated that the pharmacist is the frequent source of recommendation about medication. The most common indication for the participants to use analgesia was headache followed by insomnia.
Conclusion: The awareness and attitude of the participants to NSAIDs' usage and its complications was not that adequate. Paracetamol was the most usually used analgesic. It must to teach and strengthen the awareness among citizens about the proper method to use NSAIDs.
Evaluate the Effectiveness of Reminiscence Therapy
Authors: Bharathi A. R. 
Published: October 2021

Background: The aging begun with the birth and observed as a continuous change in different phases of life due to weakening of the body function with respect to the time and quantity. Aging also causes a continuous stress on the adaptive response and indirectly enhance the disease conditions. The adaptive childhood degree is more important to the man for his well- being and happiness. But, due to stress increasing, a strong decreased adoptability led to the increase of the inner withdrawal,bitterness, weariness of life and depression are the results of failure to adapt.
Methodology: The geriatrics eventually lead to depressed state and lack a prominentsupport. The current study aimed to analyze efficiency of the Reminiscence based therapy in aged and depressed people. The present work was based on quasi experimental nonequivalent control group designin selected senior citizen home, Chennai.Of 64 samples, experimental group (31)and control group (33) using Non-probability, purposive- sampling technique and measured based on Yesavage geriatric depression scale.
Results: Continuously, twenty-one days, two session per day (morning and evening) the experimental group were demonstrated with Reminiscence therapy. Reminiscence therapy characteristically having non-pharmacological psychosocial intervention for depression remedy. The results showed the significant difference in degree of depression between the two groups.
Conclusion: As conclusion, the study showed that reminiscence therapy had tremendously decreases the depression and elevated the well-being feeling in elder people.
Isolation of Microbes Associated With Automated Teller Machine (ATM) Keypads Studied at Rumuokoro Port Harcourt, Rivers State
Authors: Anele B. C. , Ikeh I. M. , Stanley H. O. 
Published: October 2021

The keypads of Automated Teller Machines (ATMs) are subjected to several microbial contaminations due to their large dermal contact by numerous users and different personal hygiene practice. The study investigated the bacterial diversity and level of contamination obtainable on the ATM keypads during transactions and antibiotics susceptibility pattern of the isolates. The population of culturable bacterial isolates was determined by plating. Isolates were characterized culturally, morphologically and biochemically. Antibiotic susceptibility pattern of the isolates was determined using the disc diffusion method. The total culturable heterotrophic bacterial counts ranssged from 5.23 to 9.25 log cfu/g. The bacterial identified and frequency of occurrence is Staphylococcus aureus (17.5%), Escherichia coli (22.5%), Bacillus spp (17.5%), Salmonella spp (10.0%), Pseudomonas aeruginosa (10.0%), Proteus spp (7.5%) and Klebsiella spp (15.0%) respectively. Staphylococcus aureus were more susceptible to Chloramphenicol (37mm) and were more resistant to Rifampicin (00mm) and Levofloxacin (00mm) respectively. The Gram negative isolates in the study were susceptible to ciprofloxacin and gentamycin and more resistant to ceporex, nalidixic acid, septrin and ampicillin respectively. The highest gram negative isolates that showed more susceptible to all the used gram negative antibiotics were Escherichia coli and Salmonella spp while the lowest were Klebsiella spp and Proteus spp respectively. The study has revealed that bacterial contamination on ATM keypads is of health significance and could result to public health challenges if not properly managed. Therefore, adequate hand- washing hygienic practices and cleaning agents are advocated towards reducing the related ill- health among ATM users.
Ninguém nasce homem, torna-se homem:as masculinidades no corpo e o corpo nas práticas curriculares das masculinidades
Authors: Vale Caetano Marcio Rodrigo , Da Silva Júnior Paulo Melgaço , Hernandez Jimena de Garay 
Published: October 2021

Nas atuais configurações sociais, graças aos avanços tecnológicos e as possibilidades proporcionadas com a globalização, acessamos e somos seduzidos e seduzidas por vários estilos de vida que interpelam nossa projeçãode gênero e influenciam na forma como nos percebemos e nos articulamos nas redes de sociabilidade. Como uma dessas consequências, a identidade masculina vem sendo interpelada, problematizada e desestabilizada por outras formas de vivê-la. A sua projeção unívoca identificada na apresentação branca, racional, heterossexual e judaico-cristã vem sendo fragmentada e, em suas brechas, emergem outras configurações, sobretudo após a crítica feminista ao universalismo e a emergência dos movimentos sociais de lésbicas e gays. Neste trabalho, a partir da observação e as anotações de conversas informais consideradas significantes, percorremos, balizados nos estudos culturais, os modos com que os jovens da periferia do Rio de Janeiro- Brasil constroem suas masculinidades e como elas são vividas nasescolas. Ao investigar as práticas curriculares, constatamos que, independente do entendimento de que as identidades são temporárias e contraditórias, elas se configuram em diálogo com os instrumentos educacionais que ensinam formas de ser e de viver a identidade de gênero. Durante a investigação vivenciamos a percepção de que a categoria ‘masculinidade’ foi ampliada e que sua projeção trouxe outros arranjos sexuais interagindo e criando tensões na escola.
Unraveling the Charge Storage and Activity‐Enhancing Mechanisms of Zn‐Doping Perovskite Fluorides and Engineering the Electrodes and Electrolytes for Wide‐Temperature Aqueous Supercabatteries
Authors: Jia Ziyang , Ding Rui , Yu Wujiang , Li Yi , Wang Ailin , Liu Miao , Yang Feng , Sun Xiujuan , Liu Enhui 
Published: October 2021

AbstractHerein, a trimetallic Ni–Co–Zn perovskite fluoride (ABF3) (denoted as KNCZF) electrode material is explored for advanced aqueous supercabatteries (ASCBs), with KNCZF and activated carbon–FeBiCu@reduced graphene oxides (AC–FeBiCu@rGO) as cathode and anode, respectively, which outperform aqueous supercapacitors (ASCs) and batteries (ABs) with AC and FeBiCu@rGO anodes because of the synergistic effect of pseudocapacitive (KNCZF), capacitive (AC), and faradaic (FeBiCu@rGO) responses. One of the important findings is that the KNCZF shows a typical bulk phase conversion mechanism for charge storage in the alkaline media with the transition of ABF3 perovskite nanocrystals into amorphous metal oxides/(oxy)hydroxides nanosheets, showing the redox‐active and redox‐inert roles for the Ni/Co and Zn species, respectively, which can be deduced by various ex‐situ techniques. Another interesting finding is that the redox‐inert Zn species largely enhance the activity of Ni/Co redox‐active species in the ABF3 materials, mainly owing to the promotion of surface electroactive sites, adsorption of OH−, and charge transfer of surface Ni/Co atoms by Zn‐doping, which can be proved by ex‐situ characterizations and theoretical calculations. Overall, this study reveals the structure–activity relationship and charge storage mechanisms of Zn‐doping ABF3 materials for advanced ASCBs, showing a great impact on developing advanced electrochemical energy storage.
Elemental Topological Dirac Semimetal α‐Sn with High Quantum Mobility
Authors: Anh Le Duc , Takase Kengo , Chiba Takahiro , Kota Yohei , Takiguchi Kosuke , Tanaka Masaaki 
Published: October 2021

Abstractα‐Sn provides an ideal avenue to investigate novel topological properties owing to its rich diagram of topological phases and simple elemental material structure. Thus far, however, the realization of high‐quality α‐Sn remains a challenge, which limits the understanding of its quantum transport properties and device applications. Here, epitaxial growth of α‐Sn on InSb (001) with the highest quality thus far is presented. The studied samples exhibit unprecedentedly high quantum mobilities of both the surface state (30 000 cm2 V−1 s−1), which is ten times higher than the previously reported values, and the bulk heavy‐hole state (1800 cm2 V−1 s−1), which is never obtained experimentally. These excellent features allow quantitative characterization of the nontrivial interfacial and bulk band structure of α‐Sn via a thorough investigation of Shubnikov–de Haas oscillations combined with first‐principles calculations. The results firmly identify that α‐Sn grown on InSb (001) is a topological Dirac semimetal (TDS). Furthermore, a crossover from the TDS to a 2D topological insulator and a subsequent phase transition to a trivial insulator when varying the thickness of α‐Sn are demonstrated. This work indicates that α‐Sn is an excellent model system to study novel topological phases and a prominent material candidate for topological devices.
Aggregation‐induced demulsification triggered by the hydrophilic fabric for the separation of highly emulsified oil droplets from water
Authors: Zhang Yu‐Rong , Meng Bi‐Wei , Hao Bin , Ma Peng‐Cheng 
Published: October 2021

AbstractA functional fabric with hierarchical structure consisting of basalt fibre fabric as a substrate and polyvinyl alcohol as a coating was developed, aiming at providing a low cost and high‐performance way to separate highly emulsified oil in water. The coating functioned as a hydrophilic gate for the penetration of water in the emulsion, whereas the micro‐channels formed in the fabric offered capillary force for the continuous flow of water. The synergy of these two materials led to the increase on the oil concentration in the liquid, which in turn enhanced the collision of emulsified oil droplets to aggregate into large ones in the emulsion and resulted separation from the water. Based on these findings, an aggregation‐induced demulsification process was proposed to explain the above phenomenon, and the mechanism was confirmed by studying the distribution of oil droplets in emulsion with a controlled separation degree.
Vacancy Modulating Co3Sn2S2 Topological Semimetal for Aqueous Zinc‐Ion Batteries
Authors: Zhao Yuwei , Zhu Yongbin , Jiang Feng , Li Yiyao , Meng You , Guo Ying , Li Qing , Huang Zhaodong , Zhang Shaoce , Zhang Rong , Ho Johnny C. , Zhang Qianfan , Liu Weishu , Zhi Chunyi 
Published: October 2021

AbstractWeyl semimetals (WSMs) with high electrical conductivity and suitable carrier density near the Fermi level are enticing candidates for aqueous Zn‐ion batteries (AZIBs), meriting from topological surface states (TSSs). We propose a WSM Co3Sn2S2 cathode for AZIBs showing a discharge plateau around 1.5 V. By introducing Sn vacancies, extra redox peaks from the Sn4+/Sn2+ transition appear, which leads to more Zn2+ transfer channels and active sites promoting charge‐storage kinetics and Zn2+ storage capability. Co3Sn1.8S2 achieves a specific energy of 305 Wh kg−1 (0.2 Ag−1) and a specific power of 4900 Wkg−1 (5 Ag−1). Co3Sn1.8S2 and ZnxCo3Sn1.8S2 benefit from better conductivity at lower temperatures; the quasi‐solid Co3Sn1.8S2//Zn battery delivers 126 mAh g−1 (0.6 Ag−1) at −30 °C and a cycling stability over 3000 cycles (2 Ag−1) with 85 % capacity retention at −10 °C.