bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro evaluation of nanoparticle drug-coated balloons: a pectin-RGDS-OC8H17-paclitaxel solution
Authors: Wang Peng , Gui Lin , Wang Yuji , Wang Sheng 
Published: March 2021

AbstractDrug-coated balloons have proved to be an effective technology in percutaneous transluminal angioplasty in treating peripheral artery disease. Paclitaxel-based coating is mainly used. Solutions to such problems as drug loss and inefficient drug release during operations, however, have not been found yet. This study aims to explore the activity of a newly designed paclitaxel-coated balloon in vitro using pectin as the excipient (pectin-paclitaxel) compared with the commercially available shellac excipient balloon, and to characterize the novel nanoparticle paclitaxel-coated balloon with peptide (Arg-Gly-Asp-Ser, RGDS) derivative RGDS-OC8H17 (pectin-RGDS-OC8H17-paclitaxel). Two coating solutions, pectin-paclitaxel and pectin-RGDS-OC8H17-paclitaxel, were successively designed and prepared. The morphology of both coating solutions was first characterized compared with the control group, the commercially available paclitaxel-coated balloon. Then the in vitro experiments were conducted to determine the drug-releasing profiles of both pectin-paclitaxel and pectin-RGDS-OC8H17-paclitaxel coatings. The pectin-RGDS-OC8H17-paclitaxel-coated balloon was smoother and more homogeneous compared with the commercially available paclitaxel-coated balloon and the pectin-paclitaxel-coated balloon. This difference was more obvious when paclitaxel was at low concentration. During the in vitro trial, the drug-releasing curve of the pectin-RGDS-OC8H17-paclitaxel model showed an adjustable paclitaxel-releasing: more than 90% of the paclitaxel released in 2 h at 300 rpm and more than 99% released in 10 min at 1200 rpm. Compared to the performance of the current commercially available shellac excipient products and the pectin-paclitaxel coating, pectin-RGDS-OC8H17-paclitaxel coating provided higher drug-releasing speed. However, the clinical outcomes of this finding need to be further demonstrated. Paclitaxel-coated balloons as an effective therapeutic strategy currently in treating peripheral arterial disease need to be further improved in terms of its efficiency in anti-proliferative drug delivery and release. The pectin-RGDS-OC8H17-paclitaxel coating solution developed in this study exhibited excellent drug-releasing properties. Further experiments are still needed to demonstrate the performance of this novel drug-coated balloon in vivo and its clinical importance.
Impact of climate change on sensitive marine and extreme terrestrial ecosystems: Recent progresses and future challenges
Authors: Chen Deliang 
Published: March 2021

AbstractClimate change is the greatest global threat to ecosystems on the Earth. Previous studies assessed the impacts of climate change on sensitive tropical coral reefs, extreme environments in European Alps and the Arctic with a focus on snow and permafrost. This article reflects on the past developments and future challenges for scientific research and policy response relating to these topics from a peer’s perspective. This leads to the identification of several warning signs for potentially dangerous developments in these sensitive system and extreme environments as well as opportunities for research and policy in the future. While urgent actions are required to limit global warming, science-based policy can provide needed guidance.
Direct Synthesis of Molybdenum Phosphide Nanorods on Silicon Using Graphene at the Heterointerface for Efficient Photoelectrochemical Water Reduction
Authors: Jun Sang Eon , Choi Seokhoon , Choi Shinyoung , Lee Tae Hyung , Kim Changyeon , Yang Jin Wook , Choe Woon-Oh , Im In-Hyuk , Kim Cheol-Joo , Jang Ho Won 
Published: March 2021

Highlights

MoP nanorod-array catalysts were directly synthesized on graphene passivated silicon photocathodes without secondary phase.

Mo-O-C covalent bondings and energy band bending at heterointerfaces facilitate the electron transfer to the reaction sites.

Numerous catalytic sites and drastically enhanced anti-reflectance of MoP nanorods contribute to the high solar energy conversion efficiency.

Abstract
Transition metal phosphides (TMPs) and transition metal dichalcogenides (TMDs) have been widely investigated as photoelectrochemical (PEC) catalysts for hydrogen evolution reaction (HER). Using high-temperature processes to get crystallized compounds with large-area uniformity, it is still challenging to directly synthesize these catalysts on silicon photocathodes due to chemical incompatibility at the heterointerface. Here, a graphene interlayer is applied between p-Si and MoP nanorods to enable fully engineered interfaces without forming a metallic secondary compound that absorbs a parasitic light and provides an inefficient electron path for hydrogen evolution. Furthermore, the graphene facilitates the photogenerated electrons to rapidly transfer by creating Mo-O-C covalent bondings and energetically favorable band bending. With a bridging role of graphene, numerous active sites and anti-reflectance of MoP nanorods lead to significantly improved PEC-HER performance with a high photocurrent density of 21.8 mA cm−2 at 0 V versus RHE and high stability. Besides, low dependence on pH and temperature is observed with MoP nanorods incorporated photocathodes, which is desirable for practical use as a part of PEC cells. These results indicate that the direct synthesis of TMPs and TMDs enabled by graphene interlayer is a new promising way to fabricate Si-based photocathodes with high-quality interfaces and superior HER performance.

Graphic Abstract
Roughness Measurements with Polychromatic Speckles on Tilted Surfaces
Authors: Stempin Johannes , Tausendfreund Andreas , Stöbener Dirk , Fischer Andreas 
Published: March 2021

AbstractSurface light scattering enables contactless and fast measurements of surface roughness. A surface inclination alters the direction of the scattering beam and thus the measured surface roughness is calculated from the detected intensity distribution. Hence, an accurate sensor–surface alignment is necessary. In order to achieve tilt-independent roughness measurements, a model-based evaluation approach for polychromatic speckle patterns is presented. By evaluating the shape of the superposed speckles, which occur for polychromatic illumination, with regard to the distance to the scattering centre, surfaces with an Sa roughness value in the range of 0.8–3.2 μm are measurable. Experimental investigations demonstrate that the influence of a surface tilt up to ± 1.25° on the roughness measurement is reduced by 90%. As a result, the robustness of the polychromatic speckle roughness measurement is improved, which allows to speed up the adjustment of the measurement system or the surface sample, respectively.
Spatial variability and mapping of soil fertility status in a high-potential smallholder farming area under sub-humid conditions in Zimbabwe
Authors: Soropa Gabriel , Mbisva Olton M. , Nyamangara Justice , Nyakatawa Ermson Z. , Nyapwere Newton , Lark R. Murray 
Published: March 2021

AbstractA study was conducted to examine spatial variability of soil properties related to fertility in maize fields across varying soil types in ward 10 of Hurungwe district, Zimbabwe; a smallholder farming area with sub-humid conditions and high yield potential. Purposively collected and geo-referenced soil samples were analyzed for texture, pH, soil organic carbon (OC), mineral N, bicarbonate P, and exchangeable K. Linear mixed model was used to analyze spatial variation of the data. The model allowed prediction of soil properties at unsampled sites by the empirical best linear unbiased predictor (EBLUP). Evidence for spatial dependence in the random component of the model was evaluated by calculating Akaike’s information criterion. Soil pH ranged from 4.0 to 6.9 and showed a strong spatial trend increasing from north to south, strong evidence for a difference between the home and outfields with homefields significantly higher and between soil textural classes with the sand clay loam fraction generally higher. Soil OC ranged from 0.2 to 2.02% and showed no spatial trend, but there was strong evidence for a difference between home and outfields, with mean soil OC in homefields significantly larger, and between soil textural classes, with soil OC largest in the sandy clay loams. Both soil pH and OC showed evidence for spatial dependence in the random effect, providing a basis for spatial prediction by the EBLUP, which was presented as a map. There were significant spatial trends in mineral N, available P and exchangeable K, all increasing from north to south; significant differences between homefields and outfields (larger concentrations in homefields), and differences between the soil textural classes with larger concentrations in the sandy clay loams. However, there was no evidence for spatial dependence in the random component, so no attempt was made to map these variables. These results show how management (home fields vs outfields), basic soil properties (texture) and other factors emerging as spatial trends influence key soil properties that determine soil fertility in these conditions. This implies that the best management practices may vary spatially, and that site-specific management is a desirable goal in conditions such as those which apply in Ward 10 of Hurungwe district in Zimbabwe.
Non-invasive Intrauterine Administration of Botulinum Toxin A Enhances Endometrial Angiogenesis and Improves the Rates of Embryo Implantation
Authors: Koo Hwa Seon , Yoon Min-Ji , Hong Seon-Hwa , Ahn Jungho , Cha Hwijae , Lee Danbi , Park Chan Woo , Kang Youn-Jung 
Published: March 2021

AbstractEndometrial angiogenesis plays crucial roles in determining the endometrial receptivity. Defects in endometrial receptivity often cause repeated implantation failure, which is one of the major unmet needs for infertility and contributes a major barrier to the assisted reproductive technology. Despite the numerous extensive research work, there are currently no effective evidence-based treatments to prevent or cure this condition. As a non-invasive treatment strategy, botulinum toxin A (BoTA) was administered into one side of mouse uterine horns, and saline was infused into the other side of horns for the control. Impact of BoTA was assessed in the endometrium at 3 or 8 days after infusion. We demonstrated that BoTA administration enhances the capacity of endothelial cell tube formation and sprouting. The intrauterine BoTA administration significantly induced endometrial angiogenesis displaying increased numbers of vessel formation and expression levels of related marker genes. Moreover, BoTA intrauterine application promoted the endometrial receptivity, and the rates of embryo implantation were improved with BoTA treatment with no morphologically retarded embryos. Intrauterine BoTA treatment has a beneficial effect on vascular reconstruction of functional endometrium prior to embryo implantation by increasing endometrial blood flow near the uterine cavity suggesting BoTA treatment as a potential therapeutic strategy for patients who are suffering from repeated implantation failure with the problems with endometrial receptivity.
Relationship Between Sexual Function and Pelvic Floor and Hip Muscle Strength in Women With Stress Urinary Incontinence
Authors: Hwang U.J. , Lee M.S. , Jung S.H. , Ahn S.H. , Kwon O.Y. 
Published: March 2021

Abstract

Introduction
The pelvic floor muscle (PFM) could affect female sexual functions. The hip muscles are morphologically and functionally linked to PFM and are important elements of female sexual attraction.

Aim
To determine the relationship between female sexual function and hip muscle strength and PFM functions in women with stress urinary incontinence (SUI).

Methods
A total of 42 women with SUI were recruited in this study. Female sexual function was measured using the pelvic organ prolapse urinary incontinence sexual function questionnaire (PISQ). PFM functions were measured using a perineometer. Hip muscle strength was measured using a Smart KEMA tension sensor. The relationship between female sexual function and PFM function and hip muscle strength was assessed using Pearson correlation coefficients and multiple regression analyses with forward selection.

Main Outcome Measures
PISQ score, PFM functions (strength and endurance), and strength of hip extensor, abductor, and adductor were the main outcome measures.

Results
For the behavioral/emotive domain in the PISQ, hip extensor strength (r = 0.452), PFM strength (r = 0.441), PFM endurance (r = 0.362), and hip adductor strength (r = 0.324) were significantly correlated and hip extensor strength emerged in multiple regression. For the physical domain in the PISQ, hip abductor strength (r = 0.417), PFM endurance (r = 0.356), hip adductor strength (r = 0.332), and PFM strength (r = 0.322) were significantly correlated and hip abductor strength entered in multiple regression. For partner-related domain in the PISQ, hip adductor (r = 0.386) and abductor strength (r = 0.314) were significantly correlated and hip adductor strength appeared in multiple regression. For the PISQ total score, hip extensor strength (r = 0.484), PFM endurance (r = 0.470), hip adductor strength (r = 0.424), hip abductor strength (r = 0.393), and PFM strength (r = 0.387) were significantly correlated and hip extensor strength and PFM endurance emerged in multiple regression.

Conclusion
The female sexual function could be related to not only PFM functions but also hip muscle strength in women with SUI.
The impact of natural disasters on migration: findings from Vietnam
Authors: Trinh Trong-Anh , Feeny Simon , Posso Alberto 
Published: March 2021

AbstractIncreasingly, studies are examining whether the incidence of natural disasters influences household migration. This paper examines whether the severity of natural disasters is important for migration decisions in Vietnam, rather than just examining their occurrence. Data for a sample of 1,003 farm households from the Vietnam Household Living Standard Survey are examined for the period 2006–2008. A residual generated regressor approach is adopted to isolate the direct impact of disasters on migration from the indirect impact they have on migration through reducing agricultural output and income. Findings suggest that more severe disasters are directly associated with a greater probability of migration. Furthermore, such outcomes are the same for poor householdsvis-à-vistheir non-poor counterparts.
A new method for identifying the role of marital preferences at shaping marriage patterns
Authors: Naszodi Anna , Mendonca Francisco 
Published: March 2021

AbstractWe develop a method which assumes that marital preferences are characterized either by the scalar-valued measure proposed by Liu and Lu, or by the matrix-valued generalized Liu–Lu measure. The new method transforms an observed contingency table into a counterfactual table while preserving its (generalized) Liu–Lu value. After exploring some analytical properties of the new method, we illustrate its application by decomposing changes in the prevalence of homogamy in the US between 1980 and 2010. We perform this decomposition with two alternative transformation methods as well where both methods capture preferences differently from Liu and Lu. Finally, we use survey evidence to support our claim that out of the three considered methods, the new transformation method is the most suitable for identifying the role of marital preferences at shaping marriage patterns. These data are also in favor of measuring assortativity in preferences à la Liu and Lu.
Market Privilege: The Place of Neoliberalism in American Political Development
Authors: Weaver Timothy P. R. 
Published: March 2021

AbstractSince the 1970s, the neoliberal worldview has become reflected increasingly in the policy ideas and institutional innovations advanced by both major parties in the United States. This is most obvious in the realm of economic and social policy, but especially evident at the subnational level, particularly in the city. I argue that neoliberalism, as an ideology, a set of policy prescriptions, and institutional designs, is conceptually distinct from liberalism, especially in its “New Deal” form, social democracy, and from conservatism. Moreover, it is having a developmental effect—neoliberal ideas and institutions have proved durable. This article argues that an urban lens most strikingly reveals the presence of a neoliberal political order that has also made its mark on national political institutions, particularly in the American political economy.
The implicit taxonomy of the equality jurisprudence of the UN Human Rights Committee
Authors: Petersen Niels 
Published: March 2021

AbstractThe article analyses the individual communications of the UN Human Rights Committee (HRC) on how the latter conceptualizes equality under the International Covenant on Civil and Political Rights (ICCPR). It finds an implicit taxonomy in the case law that is not reflected in the doctrinal formulae that the HRC applies. The argument proceeds in several steps: First, I argue that the concept of equality in human rights treaties depends heavily on its operationalization by courts and quasi-judicial bodies, like the HRC. Second, I analyse the doctrinal formulae that the HRC has developed in order to specify equality. I argue that the doctrine is rather inconsistent and does not give significant guidance for resolving actual cases. Third, I present the results of a systematic analysis of the case law of the HRC. The latter shows a rather stable pattern which is not reflected in the doctrinal formulae: The best predictor whether the HRC finds a violation of Article 26 ICCPR or another equality norm of the Convention is the existence of a suspect criterion on which the challenged distinction was based. There are only very few cases in which a violation is found in the absence of a suspect criterion. The majority of these cases arguably concern arbitrary state actions. At the same time, the HRC has only rarely held that a state has not violated an equality norm despite the existence of a suspect criterion.
Delivering cognitive therapy for adolescent social anxiety disorder in NHS CAMHS: a clinical and cost analysis
Authors: Leigh Eleanor , Creswell Cathy , Stallard Paul , Waite Polly , Violato Mara , Pearcey Samantha , Brooks Emma , Taylor Lucy , Warnock-Parkes Emma , Clark David M. 
Published: March 2021

AbstractBackground:Cognitive therapy, based on the Clark and Wells (1995) model, is a first-line treatment for adults with social anxiety disorder (SAD), and findings from research settings suggest it has promise for use with adolescents (Cognitive Therapy for Social Anxiety Disorder in Adolescents; CT-SAD-A). However, for the treatment to be suitable for delivery in routine clinical care, two questions need to be addressed.Aims:Can therapists be trained to achieve good outcomes in routine Child and Adolescent Mental Health Services (CAMHS), and what are the costs associated with training and treatment?Method:CAMHS therapists working in two NHS trusts received training in CT-SAD-A. They delivered the treatment to adolescents with SAD during a period of supervised practice. We examined the clinical outcomes for the 12 patients treated during this period, and estimated costs associated with treatment and training.Results:Treatment produced significant improvements in social anxiety symptoms, general anxiety and depression symptoms, and reductions in putative process measures. Seventy-five per cent (9 out of 12) patients showed a reliable and clinically significant improvement in social anxiety symptoms, and 64% (7/11) lost their primary diagnosis of SAD. The total cost to the NHS of the CT-SAD-A treatment was £4047 (SD = £1003) per adolescent treated, of which £1861 (SD = £358) referred to the specific estimated cost of face-to-face delivery; the remaining cost was for training and supervising therapists who were not previously familiar with the treatment.Conclusions:This study provides preliminary evidence that clinicians can deliver good patient outcomes for adolescents with SAD in routine CAMHS during a period of supervised practice after receiving a 2-day training workshop. Furthermore, the cost of delivering CT-SAD-A with adolescents appeared to be no more than the cost of delivering CT-SAD with adults.
Rotating savings and credit associations as traditional mutual help networks in East Asia
Authors: Onda Morio 
Published: March 2021

AbstractThis paper presents micro finance as a traditional system of mutual help networks in East Asia. These are called “Rotating Savings and Credit Associations” (ROSCAS) and can also be seen in other areas. Micro finance means that invested money is small and managed by members. Mutual help actions are divided into three categories: reciprocal, redistributional, and unidirectional action. The content of redistribution is labor, goods, and money. ROSCAS are the distributional action of money. It has been called tanaomoshi or mujin in Japan. ROSCAS have different names: South Korean ke, Chinese kai (huì), and Taiwanese hyokai (biāo huì) can be compared with the already well-studied Japanese case through the results of an interview survey and fact-finding fieldwork study. The purpose of the paper is to show that ROSCAS are important not only economically but also socially in terms of friendship and bonds. The economy is embedded in social relations and institutions. Although ROSCAS have almost disappeared from modern life and some are interest-oriented, they contributed to sustainable communities and can still be identified in East Asia. The paper concludes that modern societies might do well to reconsider ROSCAS as mutual help networks in search of ways of reconstructing communities.
Unsupervised content-preserving transformation for optical microscopy
Authors: Li Xinyang , Zhang Guoxun , Qiao Hui , Bao Feng , Deng Yue , Wu Jiamin , He Yangfan , Yun Jingping , Lin Xing , Xie Hao , Wang Haoqian , Dai Qionghai 
Published: March 2021

AbstractThe development of deep learning and open access to a substantial collection of imaging data together provide a potential solution for computational image transformation, which is gradually changing the landscape of optical imaging and biomedical research. However, current implementations of deep learning usually operate in a supervised manner, and their reliance on laborious and error-prone data annotation procedures remains a barrier to more general applicability. Here, we propose an unsupervised image transformation to facilitate the utilization of deep learning for optical microscopy, even in some cases in which supervised models cannot be applied. Through the introduction of a saliency constraint, the unsupervised model, named Unsupervised content-preserving Transformation for Optical Microscopy (UTOM), can learn the mapping between two image domains without requiring paired training data while avoiding distortions of the image content. UTOM shows promising performance in a wide range of biomedical image transformation tasks, including in silico histological staining, fluorescence image restoration, and virtual fluorescence labeling. Quantitative evaluations reveal that UTOM achieves stable and high-fidelity image transformations across different imaging conditions and modalities. We anticipate that our framework will encourage a paradigm shift in training neural networks and enable more applications of artificial intelligence in biomedical imaging.
Towards next generation white LEDs: optics-electronics synergistic effect in a single-layer heterophase halide perovskite
Authors: Rogach Andrey L. 
Published: March 2021

AbstractA novel concept of the heterophase optics-electronics synergistic effect has been demonstrated in a single-layer α/δ-heterophase perovskite CsPbI3 in order to realize white LEDs featuring only one broadband emissive layer.