bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trade openness and financial development in sub‐Saharan Africa: The role of institutional structures
Authors: Abeka Mac Junior , Gatsi John Gartchie , Appiah Michael Owusu , Agyemang Otuo Serebour 
Published: October 2021

AbstractThis article examines the role of institutional structures in the relationship between trade openness and financial development in sub‐Saharan economies. The study is based on empirical data from sampled sub‐Saharan African countries for a period of 1996–2017. The system generalized method of moment was employed to estimate the models. The findings suggest that, even though trade openness has a positive significant influence on the level of financial development in sub‐Saharan African economies, this relationship is enhanced through the presence of good institutions in these economies. Thus, for these economies to realize the full benefit of the effect of trade openness on financial development, they need to strengthen their institutions.
Classical gravitational scattering from a gauge-invariant double copy
Authors: Brandhuber Andreas , Chen Gang , Travaglini Gabriele , Wen Congkao 
Published: October 2021

AbstractWe propose a method to compute the scattering angle for classical black hole scattering directly from two massive particle irreducible diagrams in a heavy-mass effective field theory approach to general relativity, without the need of subtracting iteration terms. The amplitudes in this effective theory are constructed using a recently proposed novel colour-kinematic/double copy for tree-level two-scalar, multi-graviton amplitudes, where the BCJ numerators are gauge invariant and local with respect to the massless gravitons. These tree amplitudes, together with graviton tree amplitudes, enter the construction of the requiredD-dimensional loop integrands and allow for a direct extraction of contributions relevant for classical physics. In particular the soft/heavy-mass expansions of full integrands is circumvented, and all iterating contributions can be dropped from the get go. We use this method to compute the scattering angle up to third post-Minkowskian order in four dimensions, including radiation reaction contributions, also providing the expression of the corresponding integrand inDdimensions.
The role of right-handed neutrinos in b → cτ (πντ, ρντ, μ$$ \overline{\nu} $$μντ)$$ \overline{\nu} $$τ from visible final-state kinematics
Authors: Penalva Neus , Hernández Eliecer , Nieves Juan 
Published: October 2021

Abstract
In the context of lepton flavor universality violation (LFUV) studies, we fully derive a general tensor formalism to investigate the role that left- and right-handed neutrino new-physics (NP) terms may have in b → cτ$$ \overline{\nu} $$

ν
¯

τ transitions. We present, for several extensions of the Standard Model (SM), numerical results for the Λb → Λcτ$$ \overline{\nu} $$

ν
¯

τ semileptonic decay, which is expected to be measured with precision at the LHCb. This reaction can be a new source of experimental information that can help to confirm, or maybe rule out, LFUV presently seen in $$ \overline{B} $$

B
¯

meson decays. The present study analyzes observables that can help in distinguishing between different NP scenarios that otherwise provide very similar results for the branching ratios, which are our currently best hints for LFUV. Since the τ lepton is very short-lived, we consider three subsequent τ-decay modes, two hadronic πντ and ρντ and one leptonic μ$$ \overline{\nu} $$

ν
¯

μντ, which have been previously studied for $$ \overline{B} $$

B
¯

→ D(*) decays. Within the tensor formalism that we have developed in previous works, we re-obtain the expressions for the differential decay width written in terms of visible (experimentally accessible) variables of the massive particle created in the τ decay. There are seven different τ angular and spin asymmetries that are defined in this way and that can be extracted from experiment. Those asymmetries provide observables that can help in constraining possible SM extensions.
Zur nichtkonsensuellen Weiterleitung persönlicher erotischer Fotos an Schulen
Authors: Dekker Arne , Behrendt Pia , Pregartbauer Lea 
Published: October 2021

Zusammenfassung
Hintergrund
Neben Chancen bringen Internet und digitale Medien für Kinder und Jugendliche auch Risiken mit sich. Ein solches stellen Fälle dar, bei denen persönliche erotische Fotos von Schüler:innen gegen deren Willen weiterverbreitet werden. Für Betroffene können die psychosozialen Konsequenzen gravierend sein.

Ziel der Arbeit
Mit der vorliegenden Arbeit sollen Prävalenz von und Umgang mit der nichteinvernehmlichen Weiterleitung persönlicher erotischer Fotos unter Schüler:innen an Schulen in Schleswig-Holstein erhoben werden.

Methode
Vom 25.04. bis zum 07.06.2019 wurden die Schulleitungen von weiterführenden Schulen mittels eines Onlinekurzfragebogens sowohl zum Vorkommen nichtkonsensueller Fotoweiterleitung an den jeweiligen Schulen befragt als auch zu ergriffenen Maßnahmen, Folgen für die betroffenen Schüler:innen und Konsequenzen für diejenigen, die die Fotos versendet haben. Die Angaben von 74 Schulleitungen konnten in die Datenanalyse aufgenommen werden.

Ergebnisse
An mehr als zwei Dritteln der Schulen wurde den Schulleitungen mindestens ein Fall von nichtkonsensueller Fotoweiterleitung bekannt. Ergriffene Maßnahmen waren zumeist die Information der Eltern aller Beteiligten und ein „angeleiteter Austausch“ zwischen den beteiligten Schüler:innen. Als Folgen für die betroffenen Schüler:innen wurden v. a. sozialer Rückzug, psychisches Leiden, schulische Leistungsprobleme und Erfahrungen mit Cybermobbing/-bullying berichtet. In acht Fällen verließen betroffene Schüler:innen die Schule.

Diskussion
Nichtkonsensuelle Fotoweiterleitung an Schulen ist ein Problem erheblichen Ausmaßes. Zeitgemäße spezifische Präventionsmaßnahmen sind dringend erforderlich.
COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view
Authors: von Metzler Ivana , Campe Julia , Huenecke Sabine , Raab Marc S. , Goldschmidt Hartmut , Schubert Ralf , Rabenau Holger F. , Ciesek Sandra , Serve Hubert , Ullrich Evelyn 
Published: October 2021

Abstract
Multiple myeloma patients are often treated with immunomodulatory drugs, proteasome inhibitors, or monoclonal antibodies until disease progression. Continuous therapy in combination with the underlying disease frequently results in severe humoral and cellular immunodeficiency, which often manifests in recurrent infections. Here, we report on the clinical management and immunological data of three multiple-myeloma patients diagnosed with COVID-19. Despite severe hypogammaglobulinemia, deteriorated T cell counts, and neutropenia, the patients were able to combat COVID-19 by balanced response of innate immunity, strong CD8+ and CD4+ T cell activation and differentiation, development of specific T-cell memory subsets, and development of anti-SARS-CoV-2 type IgM and IgG antibodies with virus-neutralizing capacities. Even 12 months after re-introduction of lenalidomide maintenance therapy, antibody levels and virus-neutralizing antibody titers remained detectable, indicating persisting immunity against SARS-CoV-2. We conclude that in MM patients who tested positive for SARS-CoV-2 and were receiving active MM treatment, immune response assessment could be a useful tool to help guide decision-making regarding the continuation of anti-tumor therapy and supportive therapy.

Key messages

Immunosuppression due to multiple myeloma might not be the crucial factor that is affecting the course of COVID-19.

In this case, despite pre-existing severe deficits in CD4+ T-cell counts and IgA und IgM deficiency, we noticed a robust humoral and cellular immune response against SARS-CoV-2.

Evaluation of immune response and antibody titers in MM patients that were tested positive for SARS-CoV-2 and are on active MM treatment should be performed on a larger scale; the findings might affect further treatment recommendations for COVID-19, MM treatment re-introduction, and isolation measures.
Continua with partially constrained microstructure
Authors: Giovine Pasquale 
Published: October 2021

AbstractThe mechanical balance equations for a body with microstructure are derived from an expansion of the general Noll’s axiom of frame-indifference that takes into account the behavior of measures of microstructural interactions. Next, we introduce perfect internal constraints and adopt an extended determinism principle to analyze the consequences of their presence. Finally, we define the class of continua with partially constrained microstructure to give a complete dynamical description for a broad family of peculiar materials such as suspensions of rigid rotating granules, pseudo-Cosserat continua and partially constrained micro-spins.
Design and validation of integrated clamping interfaces for post-processing and robotic handling in additive manufacturing
Authors: Ferchow Julian , Kälin Dominik , Englberger Gokula , Schlüssel Marcel , Klahn Christoph , Meboldt Mirko 
Published: October 2021

AbstractAdditive manufacturing (AM), particularly laser-based powder bed fusion of metals (LPBF), enables the fabrication of complex and customized metallic parts. However, 20–40% of the total manufacturing costs are usually attributed to post-processing steps. To reduce the costs of extensive post-processing, the process chain for AM parts has to be automated. Accordingly, robotic gripping and handling processes, as well as an efficient clamping for subtractive machining of AM parts, are key challenges. This study introduces and validates integrated bolts acting as a handling and clamping interface of AM parts. The bolts are integrated into the part design and manufactured in the same LPBF process. The bolts can be easily removed after the machining process using a wrench. This feasibility study investigates different bolt elements. The experiments and simulations conducted in the study show that a force of 250 N resulted in a maximum displacement of 12.5 µm. The milling results of the LPBF parts reveal a maximum roughness value, Ra, of 1.42 µm, which is comparable to that of a standard clamping system. After the bolt removal, a maximum residual height of 0.067 mm remains. Two case studies are conducted to analyze the form deviation, the effect of bolts on build time, and material volume and to demonstrate the application of the bolts. Thus, the major contribution of this study is the design and the validation of standardized interfaces for robotic handling and clamping of complex AM parts. The novelties are a simple and clean interface removal, less material consumption, less support structure required, and finally an achievement of a five-side tool accessibility by combining the interfaces with a three-jaw chuck.
An adaptive time-stepping method based on a posteriori weak error analysis for large SDE systems
Authors: Merle Fabian , Prohl Andreas 
Published: October 2021

AbstractWe develop an adaptive algorithm for large SDE systems, which automatically selects (quasi-)deterministic time steps for the semi-implicit Euler method, based on an a posteriori weak error estimate. Main tools to construct the a posteriori estimator are the representation of the weak approximation error via Kolmogorov’s backward equation, a priori bounds for its solution and the Clark–Ocone formula. For a certain class of SDE systems, we validate optimal weak convergence order 1 of the a posteriori estimator, and termination of the adaptive method based on it within $${{\mathcal {O}}}(\mathtt{Tol}^{-1})$$

O
(

Tol

-
1

)

steps.
Root-Associated Bacteria Community Characteristics of Antarctic Plants: Deschampsia antarctica and Colobanthus quitensis—a Comparison
Authors: Znój Anna , Gawor Jan , Gromadka Robert , Chwedorzewska Katarzyna J. , Grzesiak Jakub 
Published: October 2021

Abstract
Colobanthus quitensis (Kunth) Bartl. and Deschampsia antarctica Desv. are the only Magnoliophyta to naturally colonize the Antarctic region. The reason for their sole presence in Antarctica is still debated as there is no definitive consensus on how only two unrelated flowering plants managed to establish breeding populations in this part of the world. In this study, we have explored and compared the rhizosphere and root-endosphere dwelling microbial community of C. quitensis and D. antarctica specimens sampled in maritime Antarctica from sites displaying contrasting edaphic characteristics. Bacterial phylogenetic diversity (high-throughput 16S rRNA gene fragment targeted sequencing) and microbial metabolic activity (Biolog EcoPlates) with a geochemical soil background were assessed. Gathered data showed that the microbiome of C. quitensis root system was mostly site-dependent, displaying different characteristics in each of the examined locations. This plant tolerated an active bacterial community only in severe conditions (salt stress and nutrient deprivation), while in other more favorable circumstances, it restricted microbial activity, with a possibility of microbivory-based nutrient acquisition. The microbial communities of D. antarctica showed a high degree of similarity between samples within a particular rhizocompartment. The grass’ endosphere was significantly enriched in plant beneficial taxa of the family Rhizobiaceae, which displayed obligatory endophyte characteristics, suggesting that at least part of this community is transmitted vertically. Ultimately, the ecological success of C. quitensis and D. antarctica in Antarctica might be largely attributed to their associations and management of root-associated microbiota.
The duration of artificial light defines sexual signalling in the common glow-worm
Authors: Elgert Christina , Lehtonen Topi K. , Kaitala Arja , Candolin Ulrika 
Published: October 2021

Abstract

Artificial light at night is increasing globally, interfering with both sensory ecology and temporal rhythms of organisms, from zooplankton to mammals. This interference can change the behaviour of the affected organisms, and hence compromise the viability of their populations. Limiting the use of artificial light may mitigate these negative effects. Accordingly, we investigated whether the duration of artificial light affects sexual signalling in female glow-worms, Lampyris noctiluca, which are flightless and attract flying males to mate by emitting glow that is interfered by light pollution. The study included three treatments: no artificial light (control), 15 min of artificial light, and 45 min of artificial light. The results show that females were more likely to cease glowing when the exposure to light was longer. Furthermore, small females were more likely to cease their glow, and responded faster to the light, than larger females. These findings suggest that glow-worms can react rapidly to anthropogenic changes in nocturnal light levels, and that prolonged periods of artificial light trigger females to stop sexual signalling. Thus, limiting the duration of artificial light can mitigate the adverse effects of light pollution on sexual signalling, highlighting the importance of such mitigation measures.

Significance statement
Interest in the effects of artificial light at night on animal behaviour has increased in recent years. With evidence for its negative impact accumulating, potential remedies, such as limiting the duration of light exposure, have emerged. To date, however, knowledge on the effectiveness of these methods has remained very limited. We show that female European common glow-worms, which are wingless beetles that glow to attract flying males to mate, responded to prolonged artificial light exposure by discontinuing their glow. Such non-glowing females are not expected to find a mate, making it difficult for them to reproduce. Hence, our study indicates that the duration of artificial light should be limited to protect this night-active beetle and its opportunities for effective sexual signalling. Because many other nocturnal species also need darkness, this study provides valuable information for the development and use of less disruptive night-time lights.
Organic crystal-based THz source for complex refractive index measurements of window materials using single-shot THz spectroscopy
Authors: Du Lufan , Roeder Franz , Li Yun , Shalaby Mostafa , Beleites Burgard , Ronneberger Falk , Gopal Amrutha 
Published: October 2021

AbstractWe employed N-benzyl-2-methyl-4-nitroaniline (BNA) crystals bonded on substrates of different thermal conductivity to generate THz radiation by pumping with 800 nm laser pulses. Crystals bonded on sapphire substrate provided four times more THz yield than glass substrate. A pyrodetector and a single-shot electro-optic (EO) diagnostic were employed for measuring the energy and temporal characterisation of the THz pulse. Systematic studies were carried out for the selection of a suitable EO crystal, which allowed accurate determination of the emitted THz spectrum from both substrates. Subsequently, the THz source and single-shot electro-optic detection scheme were employed to measure the complex refractive index of window materials in the THz range.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastases: analysis of short- and long-term outcomes
Authors: Rosa Fausto , Galiandro Federica , Ricci Riccardo , Di Miceli Dario , Quero Giuseppe , Fiorillo Claudio , Cina Caterina , Alfieri Sergio 
Published: October 2021

Abstract
Background
Peritoneal metastases carry the worst prognosis among all sites of colorectal cancer (CRC) metastases. In recent years, the advent of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival for selected patients with limited peritoneal involvement. We report the evolution of CRS and HIPEC for colorectal peritoneal metastases at a tertiary referral center over a 10-year period.

Methods
Patients with colorectal peritoneal metastases undergoing CRS and HIPEC were included and retrospectively analyzed at a tertiary referral center from January 2006 to December 2015. Main outcomes included evaluation of grade III/IV complications, mortality rate, overall and disease-free survival, and prognostic factors influencing survival on a Cox multivariate analysis.

Results
Sixty-seven CRSs were performed on 67 patients during this time for colorectal peritoneal metastases. The median patient age was 57 years with 55.2% being female. The median peritoneal carcinomatosis index (PCI) was 7, with complete cytoreduction achieved in 65 (97%) cases. Grade > 2 complications occurred in 6 cases (8.9%) with no mortality. The median overall survival for the entire cohort was 41 months, with a 3-year overall survival of 43%. In case of complete cytoreduction, median overall and disease-free survival were 57 months and 36 months respectively, with a 3-year disease-free survival of 62%. Complete cytoreduction and nonmucinous histology were key factors independently associated with improved overall survival.

Conclusions
CRS and HIPEC for limited peritoneal metastases from CRC are safe and effective, with acceptable morbidity. In selected patients, it offers a highly favorable long-term outcomes.
Changes in characteristics and outcomes of critically ill COVID-19 patients in Tyrol (Austria) over 1 year
Authors: Mayerhöfer Timo , Klein Sebastian J. , Peer Andreas , Perschinka Fabian , Lehner Georg F. , Hasslacher Julia , Bellmann Romuald , Gasteiger Lukas , Mittermayr Markus , Eschertzhuber Stephan , Mathis Simon , Fiala Anna , Fries Dietmar , Kalenka Armin , Foidl Eva , Hasibeder Walter , Helbok Raimund , Kirchmair Lukas , Stögermüller Birgit , Krismer Christoph , Heiner Tatjana , Ladner Eugen , Thomé Claudius , Preuß-Hernandez Christian , Mayr Andreas , Pechlaner Agnes , Potocnik Miriam , Reitter Bruno , Brunner Jürgen , Zagitzer-Hofer Stefanie , Ribitsch Alexandra , Joannidis Michael 
Published: October 2021

SummaryBackgroundWidely varying mortality rates of critically ill Coronavirus disease 19 (COVID-19) patients in the world highlighted the need for local surveillance of baseline characteristics, treatment strategies and outcome. We compared two periods of the COVID-19 pandemic to identify important differences in characteristics and therapeutic measures and their influence on the outcome of critically ill COVID-19 patients.MethodsThis multicenter prospective register study included all patients with a SARS-CoV‑2 infection confirmed by polymerase chain reaction, who were treated in 1 of the 12 intensive care units (ICU) from 8 hospitals in Tyrol, Austria during 2 defined periods (1 February 2020 until 17 July: first wave and 18 July 2020 until 22 February 2021: second wave) of the COVID-19 pandemic.ResultsOverall, 508 patients were analyzed. The majority (n = 401) presented during the second wave, where the median age was significantly higher (64 years, IQR 54–74 years vs. 72 years, IQR 62–78 years,p < 0.001). Invasive mechanical ventilation was less frequent during the second period (50.5% vs 67.3%,p = 0.003), as was the use of vasopressors (50.3% vs. 69.2%,p = 0.001) and renal replacement therapy (12.0% vs. 19.6%,p = 0.061), which resulted in shorter ICU length of stay (10 days, IQR 5–18 days vs. 18 days, IQR 5–31 days,p < 0.001). Nonetheless, ICU mortality did not change (28.9% vs. 21.5%,p = 0.159) and hospital mortality even increased (22.4% vs. 33.4%,p = 0.039) in the second period. Age, frailty and the number of comorbidities were significant predictors of hospital mortality in a multivariate logistic regression analysis of the overall cohort.ConclusionAdvanced treatment strategies and learning effects over time resulted in reduced rates of mechanical ventilation and vasopressor use in the second wave associated with shorter ICU length of stay. Despite these improvements, age appears to be a dominant factor for hospital mortality in critically ill COVID-19 patients.
European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part I: assessment
Authors: Szejko Natalia , Robinson Sally , Hartmann Andreas , Ganos Christos , Debes Nanette M. , Skov Liselotte , Haas Martina , Rizzo Renata , Stern Jeremy , Münchau Alexander , Czernecki Virginie , Dietrich Andrea , Murphy Tara L. , Martino Davide , Tarnok Zsanett , Hedderly Tammy , Müller-Vahl Kirsten R. , Cath Danielle C. 
Published: October 2021

AbstractIn 2011 a working group of the European Society for the Study of Tourette Syndrome (ESSTS) has developed the first European assessment guidelines for Tourette syndrome (TS). Now, we present an updated version 2.0 of these European clinical guidelines for Tourette syndrome and other tic disorders, part I: assessment. Therefore, the available literature has been thoroughly screened, supplemented with national guidelines across countries and discussions among ESSTS experts. Diagnostic changes between DSM-IV and DSM-5 classifications were taken into account and new information has been added regarding differential diagnoses, with an emphasis on functional movement disorders in both children and adults. Further, recommendations regarding rating scales to evaluate tics, comorbidities, and neuropsychological status are provided. Finally, results from a recently performed survey among ESSTS members on assessment in TS are described. We acknowledge that the Yale Global Tic Severity Scale (YGTSS) is still the gold standard for assessing tics. Recommendations are provided for scales for the assessment of tics and psychiatric comorbidities in patients with TS not only in routine clinical practice, but also in the context of clinical research. Furthermore, assessments supporting the differential diagnosis process are given as well as tests to analyse cognitive abilities, emotional functions and motor skills.