bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing presidential particularism: bureaucracy and the distribution of federal grants
Authors: Napolio Nicholas G. 
Published: July 2021

AbstractDo agencies implement the president's particularistic goals uniformly? This paper clarifies the presidential particularism literature by explicitly considering the mechanism through which the president pursues their policy goals: executive agencies. The constellation of bureaucratic agencies responsible for allocating grants plays a key role in facilitating or frustrating presidential policy priorities. Using a dataset of 21 agencies over 14 years, I find that only agencies ideologically proximate to the president engage in particularism benefiting the president. I find no evidence that politicization influences agency implementation of particularism. Critically, the moderating effect of the bureaucracy on particularism only occurs for distributive programs over which agencies have discretion. When disbursing formula grants written by Congress but administered by the bureaucracy with little or no discretion, ideological distance between agencies and presidents has no effect on particularism.
Foreign Aid and Soft Power: Great Power Competition in Africa in the Early Twenty-first Century
Authors: Blair Robert A. , Marty Robert , Roessler Philip 
Published: July 2021

AbstractIs foreign aid an effective instrument of soft power? Does it generate affinity for donor countries and the values they espouse? This article answers these questions in the context of Chinese aid to Africa and the competing aid regime of the United States. The study combines data on thirty-eight African countries from Afrobarometer, AidData, and the Aid Information Management Systems of African finance and planning ministries. The authors use spatial difference-in-differences to isolate the causal effects of Chinese and US aid. The study finds that Chinese aid to Africa does not increase (and may in fact reduce) beneficiaries’ support for China. By contrast, US aid appears to increase support for the United States and to strengthen recipients’ commitment to liberal democratic values, such as the belief in the importance of elections. Chinese aid does not appear to weaken this commitment, and may strengthen it. The study also finds that Chinese aid increases support for the UK, France and other former colonial powers. These findings advance our understanding of the conditions under which competing aid regimes generate soft power and facilitate the transmission of political principles and ideals.
Flattening the Illiquidity Curve: Retail Trading During the COVID-19 Lockdown
Authors: Ozik Gideon , Sadka Ronnie , Shen Siyi 
Published: July 2021

AbstractThis article studies the impact of retail investors on stock liquidity during the COVID-19 pandemic lockdown in spring 2020. Retail trading exhibits a sharp increase, especially among stocks with high COVID-19–related media coverage. Retail trading attenuated the rise in illiquidity by roughly 40% but less so for high-media-attention stocks. Causality is addressed using the staggered implementation of the stay-at-home advisory across U.S. states. The results highlight that ample free time and access to financial markets facilitated by fintech innovations to trading platforms are significant determinants of retail-investor stock market participation.
Assessment of anthelmintic effectiveness to control Fasciola hepatica and paramphistome mixed infection in cattle in the humid tropics of Mexico
Authors: Ico-Gómez Rodrigo , González-Garduño Roberto , Ortiz-Pérez Diego , Mosqueda-Gualito Juan J. , Flores-Santiago Ever del J. , Sosa-Pérez Gustavo , Salazar-Tapia Abel A. 
Published: July 2021

AbstractThe objective of this study was to evaluate the effectiveness of the main anthelmintics used for the control of trematodes in cattle in an endemic area in the humid Mexican tropics. A diagnostic study was carried out in nine cattle farms to determine the prevalence of flukes through faecal examination. Only three farms with more than 20 cows positive to trematodes were chosen to determine the effectiveness of commercial anthelmintics (triclabendazole, TCBZ; ivermectin + closantel, (IVM + CLOS); IVM + clorsulon, (CLORS); nitroxynil, NITROX). The prevalence of Fasciola hepatica was 27.1% and 29.6% of paramphistomes. The faecal egg count of trematodes ranged from 0.0 to 12.2 eggs per gram of faeces. The highest effectiveness against F. hepatica was 96.7%, and 92.7% against paramphistomes. NITROX was the most effective in the control of trematodes, while other products, such as IVM + CLORS and TCBZ obtained values lower than 90%, which puts sustainable trematode control at risk. The presence of trematodes was observed on most farms, although the prevalence per herd was highly variable, which indicates that the trematodes F. hepatica and paramphistomes are endemic to the region and a suitable management programme is suggested to control infections caused by these parasites.
Technological Change and the International System
Authors: Milner Helen V. , Solstad Sondre Ulvund 
Published: July 2021

ABSTRACTDo world politics affect the adoption of new technology? States overwhelmingly rely on technology invented abroad, and their differential intensity of technology use accounts for many of their differences in economic development. Much of the literature on technology adoption focuses on domestic conditions. The authors argue instead that the structure of the international system is critical because it affects the level of competition among states, which in turn affects leaders’ willingness to enact policies that speed technology adoption. Countries adopt new technology as they seek to avoid being vulnerable to attack or coercion by other countries. By systematically examining states’ adoption of technology over the past two hundred years, the authors find that countries adopt new technologies faster when the international system is less concentrated, that changes in systemic concentration have a temporally causal effect on technology adoption, and that government policies to promote technology adoption are related to concerns about rising international competition. A competitive international system is an important incentive for technological change and may underlie global technology waves.
PHONOLOGICAL PROCESSING OF STRESS BY NATIVE ENGLISH SPEAKERS LEARNING SPANISH AS A SECOND LANGUAGE
Authors: Ortín Ramsés , Simonet Miquel 
Published: July 2021

AbstractOne feature of Spanish that presents some difficulties to second language (L2) learners whose first language (L1) is English concerns lexical stress. This study explores one aspect of the obstacle these learners face, weak phonological processing routines concerning stress inherited from their native language. Participants were L1 English L2 learners of Spanish. The experiment was a sequence-recall task with auditory stimuli minimally contrasting in stress (target) or segmental composition (baseline). The results suggest that learners are more likely to accurately recall sequences with stimuli contrasting in segmental composition than stress, suggesting reduced phonological processing of stress relative to a processing baseline. Furthermore, an increase in proficiency—assessed by means of grammatical and lexical tests—was found to be modestly associated with an increase in the accuracy of processing stress. We conclude that the processing routines of native English speakers lead to an acquisitional obstacle when learning Spanish as a L2.
The Starting Big approach to language learning
Authors: ARNON Inbal 
Published: July 2021

AbstractThe study of language acquisition has a long and contentious history: researchers disagree on what drives this process, the relevant data, and the interesting questions. Here, I outline the Starting Big approach to language learning, which emphasizes the role of multiword units in language, and of coarse-to-fine processes in learning. I outline core predictions and supporting evidence. In short, the approach argues that multiword units are integral building blocks in language; that such units can facilitate mastery of semantically opaque relations between words; and that adults rely on them less than children, which can explain (some of) their difficulty in learning a second language. The Starting Big approach is a theory of how children learn language, how language is represented, and how to explain differences between first and second language learning. I discuss the learning and processing models at the heart of the approach and their cross-linguistic implications.
Food insecurity and the double burden of malnutrition in Colombian rural households
Authors: Sansón-Rosas Ana María , Bernal-Rivas Jennifer , Kubow Stan , Suarez-Molina Andrés , Melgar-Quiñonez Hugo 
Published: July 2021

AbstractObjective:This study aimed to examine in Colombian rural households the association between different severity levels of household food insecurity and the presence of the double burden of malnutrition (SCOWT), defined as the coexistence of a stunted child under 5 years of age and an overweight or obese (OWOB) mother.Design:A secondary data analysis was conducted using cross-sectional data from the Colombian National Nutritional Survey (ENSIN) 2015. Household food insecurity status was assessed by using the Latin-American and Caribbean Food Security Scale (ELCSA). The household SCOWT status (child stunting and OWOB mother) was determined using anthropometric data from a mother and her child.Setting:Rural Colombia.Participants:Totally, 2·350 mother–child pairs living in the same household.Results:Sixty-two per cent of the households were food-insecure and SCOWT was present in 7·8 % of the households. Moderate (OR: 2·39, 95 % CI (1·36, 4·21)) and severe (OR: 1·86, 95 % CI (1·10, 3·15)) food insecurity was associated with SCOWT in an unadjusted logistic regression. Only moderate food insecurity remained significantly associated with SCOWT in a multivariate logistic regression (adjusted OR: 2·41, 95 % CI (1·24, 4·68)).Conclusions:Colombian rural areas are not exempt from the worldwide concern of increasing OWOB rates while stunting is still persistent. These results highlight the need of implementing double-duty rural actions targeting the most vulnerable households to SCOWT, particularly in terms of overcoming food insecurity beyond hunger satisfaction to prevent all forms of malnutrition.
Design of a linear to circular polarization converter integrated into a concrete construction for radome applications
Authors: Öztürk Murat , Sevim Umur Korkut , Altıntaş Olcay , Ünal Emin , Akgöl Oğuzhan , Karaaslan Muharrem , Sabah Cumali 
Published: July 2021

AbstractIn this paper, we present a linear to circular polarization converter integrated in a concrete structure to eliminate signal transmission problem originated from the concrete buildings in microwave regime. Two polarization converter samples and a control specimen made by traditional concrete are designed and their signal transmission responses are compared experimentally. Axial ratio values which can be calculated by the ratio between the co-polar transmission and cross-polar transmission results of the proposed samples are below 3 dB and highly sufficient for linear to circular polarization conversion activity. The operating frequency for the proposed sample 1 is between 6 and 6.5 GHz with 500 MHz of bandwidth. The proposed sample 2 exhibits dual-band operation covering frequency bands, 4.58–5.13 and 6.0–6.4 GHz with bandwidths of 550 and 400 MHz, respectively. Operating frequencies of the samples are in the WIMAX frequency bands. In addition, the liner to circular polarization converter design integrated to concrete has a huge potential to improve reflection and directivity parameters of many antennas if it is considered as a radome.
Evaluating Precipitation Errors Using the Environmentally Conditioned Intensity‐Frequency Decomposition Method
Authors: Di Luca A. , Argüeso D. , Sherwood S. , Evans J. P. 
Published: July 2021

AbstractA fundamental issue when evaluating the simulation of precipitation is the difficulty of quantifying specific sources of errors and recognizing compensation of errors. We assess how well a large ensemble of high‐resolution simulations represents the precipitation associated with strong cyclones. We propose a framework to breakdown precipitation errors according to different dynamical (vertical velocity) and thermodynamical (vertically integrated water vapor) regimes and the frequency and intensity of precipitation. This approach approximates the error in the total precipitation of each regime as the sum of three terms describing errors in the large‐scale environmental conditions, the frequency of precipitation and its intensity. We show that simulations produce precipitation too often, that its intensity is too weak, that errors are larger for weak than for strong dynamical forcing and that biases in the vertically integrated water vapor can be large. Using the error breakdown presented above, we define four new error metrics differing on the degree to which they include the compensation of errors. We show that convection‐permitting simulations consistently improve the simulation of precipitation compared to coarser‐resolution simulations using parameterized convection, and that these improvements are revealed by our new approach but not by traditional metrics which can be affected by compensating errors. These results suggest that convection‐permitting models are more likely to produce better results for the right reasons. We conclude that the novel decomposition and error metrics presented in this study give a useful framework that provides physical insights about the sources of errors and a reliable quantification of errors.
Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis
Authors: Heurich Meike , Föcking Melanie , Mongan David , Cagney Gerard , Cotter David R. 
Published: July 2021

AbstractEarly identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psychosis, enabling stratification of individuals who are most likely to transition to psychotic disorder from those who are not. This reinforces the concept that the psychosis spectrum is likely a central nervous system manifestation of systemic changes and highlights the need to investigate plasma proteins as diagnostic or prognostic biomarkers and pathophysiological mediators. In this review, we integrate evidence of alterations in proteins belonging to the complement and coagulation protein systems, including the coagulation, anticoagulation, and fibrinolytic pathways and their dysregulation in psychosis, into a consolidated mechanism that could be integral to the progression and manifestation of psychosis. We consolidate the findings of altered blood proteins relevant for progression to psychotic disorders, using data from longitudinal studies of the general population in addition to clinical high-risk (CHR) individuals transitioning to psychotic disorder. These are compared to markers identified from first-episode psychosis and schizophrenia as well as other psychosis spectrum disorders. We propose the novel hypothesis that altered complement and coagulation plasma levels enhance their pathways’ activating capacities, while low levels observed in key regulatory components contribute to excessive activation observed in patients. This hypothesis will require future testing through a range of experimental paradigms, and if upheld, complement and coagulation pathways or specific proteins could be useful diagnostic or prognostic tools and targets for early intervention and preventive strategies.
Mental health and music engagement: review, framework, and guidelines for future studies
Authors: Gustavson Daniel E. , Coleman Peyton L. , Iversen John R. , Maes Hermine H. , Gordon Reyna L. , Lense Miriam D. 
Published: July 2021

AbstractIs engaging with music good for your mental health? This question has long been the topic of empirical clinical and nonclinical investigations, with studies indicating positive associations between music engagement and quality of life, reduced depression or anxiety symptoms, and less frequent substance use. However, many earlier investigations were limited by small populations and methodological limitations, and it has also been suggested that aspects of music engagement may even be associated with worse mental health outcomes. The purpose of this scoping review is first to summarize the existing state of music engagement and mental health studies, identifying their strengths and weaknesses. We focus on broad domains of mental health diagnoses including internalizing psychopathology (e.g., depression and anxiety symptoms and diagnoses), externalizing psychopathology (e.g., substance use), and thought disorders (e.g., schizophrenia). Second, we propose a theoretical model to inform future work that describes the importance of simultaneously considering music-mental health associations at the levels of (1) correlated genetic and/or environmental influences vs. (bi)directional associations, (2) interactions with genetic risk factors, (3) treatment efficacy, and (4) mediation through brain structure and function. Finally, we describe how recent advances in large-scale data collection, including genetic, neuroimaging, and electronic health record studies, allow for a more rigorous examination of these associations that can also elucidate their neurobiological substrates.
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma
Authors: Tian Yu , Tang Bo , Wang Chengye , Wang Yan , Mao Jiakai , Yao Yifan , Gao Zhenming , Liang Rui , Ye Mingliang , Cai Shijie , Wang Liming 
Published: July 2021

AbstractOncogenic ubiquitin-specific protease 22 (USP22) is implicated in a variety of tumours; however, evidence of its role and underlying molecular mechanisms in cholangiocarcinoma (CCA) development remains unknown. We collected paired tumour and adjacent non-tumour tissues from 57 intrahepatic CCA (iCCA) patients and evaluated levels of the USP22 gene and protein by qPCR and immunohistochemistry. Both the mRNA and protein were significantly upregulated, correlated with the malignant invasion and worse OS of iCCA. In cell cultures, USP22 overexpression increased CCA cell proliferation and mobility, and induced epithelial-to-mesenchymal transition (EMT). Upon an interaction, USP22 deubiquitinated and stabilized sirtuin-1 (SIRT1), in conjunction with Akt/ERK activation. In implantation xenografts, USP22 overexpression stimulated tumour growth and metastasis to the lungs of mice. Conversely, the knockdown by USP22 shRNA attenuated the tumour growth and invasiveness in vitro and in vivo. Furthermore, SIRT1 overexpression reversed the USP22 functional deficiency, while the knockdown acetylated TGF-β-activated kinase 1 (TAK1) and Akt. Our present study defines USP22 as a poor prognostic predictor in iCCA that cooperates with SIRT1 and facilitates tumour development.
DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury
Authors: Bao Yinwu , Bai Mengqiu , Zhu Huanhuan , Yuan Yuan , Wang Ying , Zhang Yunjing , Wang Junni , Xie Xishao , Yao Xi , Mao Jianhua , Fu Xianghui , Chen Jianghua , Yang Yi , Lin Weiqiang 
Published: July 2021

AbstractDemethylase Tet2 plays a vital role in the immune response. Acute kidney injury (AKI) initiation and maintenance phases are marked by inflammatory responses and leukocyte recruitment in endothelial and tubular cell injury processes. However, the role of Tet2 in AKI is poorly defined. Our study determined the degree of renal tissue damage associated with Tet2 gene expression levels in a cisplatin-induced AKI mice model. Tet2-knockout (KO) mice with cisplatin treatment experienced severe tubular necrosis and dilatation, inflammation, and AKI markers’ expression levels than the wild-type mice. In addition, the administration of Tet2 plasmid protected Tet2-KO mice from cisplatin-induced nephrotoxicity, but not Tet2-catalytic-dead mutant. Tet2 KO was associated with a change in metabolic pathways like retinol, arachidonic acid, linolenic acid metabolism, and PPAR signaling pathway in the cisplatin-induced mice model. Tet2 expression is also downregulated in other AKI mice models and clinical samples. Thus, our results indicate that Tet2 has a renal protective effect during AKI by regulating metabolic and inflammatory responses through the PPAR signaling pathway.
The emerging role of WWP1 in cancer development and progression
Authors: Hu Xiaoli , Yu Jiangtao , Lin Zixia , Feng Renqian , Wang Zhi-wei , Chen Gang 
Published: July 2021

AbstractEmerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association between dysregulated WWP1 expression and clinical features of cancer patients. Moreover, we summarize the both oncogenic and tumor suppressive functions of WWP1 in a variety of human cancers. Furthermore, we briefly describe the downstream substrates of WWP1 and its upstream factors to regulate the expression of WWP1. Notably, targeting WWP1 by its inhibitors or natural compounds is potentially useful for treating human malignancies. Finally, we provide the perspectives regarding WWP1 in cancer development and therapies. We hope this review can stimulate the research to improve our understanding of WWP1-mediated tumorigenesis and accelerate the discovery of novel therapeutic strategies via targeting WWP1 expression in cancers.
NF-κB is involved in the regulation of autophagy in mutant p53 cells in response to ionizing radiation
Authors: Zhu Ying , Zuo Wenqing , Shen Xiao , Liu Yali , Zhao Yifan , Xiong Yajie , Cao Huimin , Wang Yan , Liang Zhongqin 
Published: July 2021

AbstractChemotherapy and ionizing radiation (IR) can induce autophagy in tumor cells. Here, we report that the level of autophagy in tumor cells was related to the background of p53 gene that NF-κB acts as a negative regulator of autophagy in mutant p53 (p53-R273H) cells, and that acetylation was involved in the IR-induced nuclear translocation of NF-κB. We found that autophagy-related proteins were highly expressed in wild-type p53 (wt-p53) cells and that IR increased their levels further. p53-R273H cells exhibited low levels of autophagy; there was no change following IR treatment. The nuclear translocation of p65 was upregulated in p53-R273H cells following IR; when p65 was competitively inhibited from entering the nucleus with SN50, the level of autophagy increased. The nuclear translocation of p65 was mediated by p300; this factor also regulates the nuclear behavior of NF-κB. The knockdown of p300 in p53-R273H cells led to an inhibition of p65 expression and an increase in autophagy. In addition, the inhibition of p300 or p65 not only activated autophagy, it also induced radiosensitivity in p53-R273H cells. The relationship between the p53 gene, NF-κB, and autophagy was further analyzed in a mouse model of xenograft tumors and in clinical tumor pathological specimens; the results were consistent with the in vitro experiments. Our findings indicate that autophagy may be regulated by NF-κB in p53-R273H cells. These findings may help to improve the therapeutic strategy adopted for tumors related to the mutant p53-R273H gene; such therapy would aim to target NF-κB to induce autophagy.