bluuebunny/crossref_metadata_2025_split huggingface dataset:
O impacto da pandemia do COVID-19 na gestão financeira das micro e pequenas empresas do setor varejista de Cláudio-MG
Authors: Salomé Fernanda Franciele  Sousa , Sousa Raímme Mayra do Nascimento , Sousa Raquel Elaine Amaral de , Silva Valdilene Gonçalves Machado 
Published: June 2021

O objetivo deste trabalho foi analisar o impacto da pandemia do COVID-19 na gestão financeira das micro e pequenas empresas do setor varejista de Cláudio-MG. Foi realizada uma pesquisa exploratória, com abordagem quantitativa, através de um estudo de caso das micro e pequenas empresas do setor varejista que fizeram parte da campanha “Comércio Consciente contra a COVID-19”, em Cláudio-MG. As informações foram coletadas através de questionário utilizando-se o aplicativo google formulários. Identificou-se que a maioria das empresas eram preponderantemente do ramo de vestuário e atuavam no mercado entre dois e cinco anos. A gestão financeira era realizada pelos próprios empreendedores, em sua maioria do gênero feminino, atuavam na área financeira de um a cinco anos, possuíam ensino médio completo e não tinham formação na área financeira, porém, durante a pandemia alguns buscaram capacitação na área. Antes da pandemia a maior parte da amostra estava com o faturamento em crescimento, conseguiam pagar suas contas em dia e não era da prática diária das empresas a utilização sistemática de ferramentas de gestão financeira. Sendo que, as mais utilizadas eram o controle de fluxo de caixa, o controle de contas a pagar e receber, o controle de custos, o controle de estoque e realizavam vendas pelo cartão de crédito. Com a crise ocasionada pela pandemia o faturamento diminuiu e começaram a ter mais dificuldade de manter os pagamentos em dia. Uma parte delas teve aumento dos custos com pessoal, impostos, energia elétrica, entre outros. Continuaram utilizando as mesmas ferramentas empregadas antes da pandemia, porém mais empresas passaram a aplicar as mesmas. A análise da necessidade de capital de giro, que era pouco usada passou a ser utilizada pelas organizações. Portanto, os principais impactos ocasionados pela crise decorrente da pandemia sobre a maioria das empresas foram negativos, entre eles estão a queda do faturamento; a mudança na forma de funcionamento da empresa; o aumento dos gastos, principalmente com pessoal, energia elétrica, água e impostos; a demissão ou afastamento de funcionários, redução da jornada de trabalho e suspensão do contrato de trabalho; entre outros. Porém, algumas tiveram impacto positivo, considerando que houve aumento do faturamento.
Uma proposta de aula prática para facilitar o ensino de Bioquímica: Identificando a ação proteolítica de frutas tropicais e do amaciante de carne
Authors: Gonçalves Tiago Maretti 
Published: June 2021

A Bioquímica é uma vertente da Biologia fascinante que possui como principal objetivo o estudo da química da vida. No entanto, no Ensino Médio ela é encarada por muitos alunos como uma área complexa e abstrata. Para superarmos tais obstáculos, o objetivo do presente trabalho é a proposta de uma atividade metodológica prática com o intuito de facilitar e instigar a aprendizagem dos alunos dentro da disciplina de Biologia no Ensino Médio. Nesse sentido, é utilizado materiais simples e de baixo custo, na abordagem da identificação proteolítica de proteínas com o uso de sucos de frutas tropicais como o abacaxi, mamão, kiwi e o amaciante de carnes em pó, na degradação da gelatina e de fibras da carne de boi. Por ser uma atividade que não demanda a existência de um laboratório físico, os próprios alunos podem replicá-la em suas próprias casas, sendo altamente recomendada nos dias de hoje, em que as aulas estão seguindo um modelo virtual, em detrimento ao novo coronavírus (SARS-CoV-2). Assim, acreditamos que a proposta metodológica experimental, possa facilitar a aprendizagem dos alunos no tema proposto, despertando o seu lado científico, promovendo a discussão e a problematização de hipóteses na realização do experimento. Por fim, com essa atividade prática, o professor pode trabalhar com os discentes, outros assuntos da Biologia como a Botânica e até mesmo a Fisiologia Animal do sistema digestório.
COVID-19 and Mental health in School-Aged Children and Young People: Thinking ahead while preparing the return to school and to life “as usual”
Authors: Gaspar de Matos Margarida , Wainwright Tony 
Published: June 2021

From December 2019 onwards, the COVID-19 pandemic brought with it several health, social and economic issues, particularly associated with home confinement measures, lockdown, and fear of being infected or otherwise affected by the virus, or even die. As with everybody else, children and young people are experiencing a new reality. The question is how well, and how long will it take for recovery. Furthermore, what is the likely affective, social, academic and economic cost for this recovery. There are at least four psychosocial scenarios that must be separately analysed: children and young people with previous mental ill health that may be left unattended by health services; those who may have a first episode of mental ill health during home confinement and had no health care; those with psychosocial vulnerabilities that may be left under-monitored and exposed to undermining circumstances, and finally those that have faced a huge change in their routines and may have formed a relatively stable pessimistic outlook that affects their wellbeing. Social isolation and quarantine have precipitated a decrease in wellbeing and an increase in mental health problems and psychosocial vulnerabilities, plus a lowering of general capacity for health, education and social security care. Confined children and young people are separated from their usual social support, deprived of the personal freedom that they are used to, and see a comprehensive change in the usual life routine and lifestyle with an enormous change in physical, social, affective and even digital environments. All children and young people are in need of a monitoring system and of arrangements to promote social participation and engagement, that runs at the same time as their return to school. Mitigating negative mental health effects requires a concerted effort from the general population, policy makers, education and healthcare professionals. Moreover, international health and educational organisations have advised governments that this action would benefit by being proactive: meaning there is an urgent need to get ready immediately – being ready for the “day after”, thinking ahead and being able to put together in the field and on time, an adequate nation-wide, participatory, multidisciplinary, mental health related set of interventions.
Prolonged Hypophosphatemia and Intensive Care After Curative Surgery of Tumor Induced Osteomalacia: A Case Report
Authors: Ryhänen Eeva M. , Schalin-Jäntti Camilla , Matikainen Niina 
Published: June 2021

IntroductionRare FGF23-producing mesenchymal tumors lead to paraneoplastic tumor-induced osteomalacia (TIO) presenting with phosphate wasting, hypophosphatemia, chronic hypomineralization of the bone, fragility fractures and muscle weakness. Diagnosis of TIO requires exclusion of other etiologies and careful search for a mesenchymal tumor that often is very small and can appear anywhere in the body. Surgical removal of the tumor is the only definitive treatment of TIO. Surgical complications due to chronic hypophosphatemia are not well recognized.Case DescriptionThe current case describes severe fragility fractures in a 58-year-old woman, who lost her ability to walk and was bedridden for two years. First, the initial diagnostic laboratory work-up did not include serum phosphorus measurements, second, the suspicion of adverse effects of pioglitazone as an underlying cause delayed correct diagnosis for at least two years. After biochemical discovery of hyperphosphaturic hypophosphatemia at a tertiary referral centre, a FGF23-producing tumor of the mandible was discovered on physical examination, and then surgically removed. Postoperatively, severe hypophosphatemia and muscle weakness prolonged the need for ventilation support, intensive care and phosphate supplementation. After two years of rehabilitation, the patient was able to walk short distances. The tumor has not recurred, and serum phosphate concentration has remained within normal limits during 3.5 years of follow-up.ConclusionsThe case report illustrates knowledge gaps in the diagnostic work-up of rare causes of low bone mass and fragility fractures. Compared to other low phosphate conditions, surgical recovery from TIO-induced hypophosphatemia warrants special attention. Increased alkaline phosphatase concentration may indicate impaired postsurgical recovery due to prolonged hypophosphatemia, underlining the need for proactive perioperative correction of hypophosphatemia.
Identification of a Competing Endogenous RNA Network Related to Immune Signature in Lung Adenocarcinoma
Authors: Zhu Ting , Yu Yong , Liu Jun , Ren Kaiming 
Published: June 2021

BackgroundThe establishment of immunotherapy has led to a new era in oncotherapy. But the signature of immune-related genes (IRGs) in LUAD remains to be elucidated. Here we use integrated analysis to identify IRGs roles in immune signature and detect their relationship with competing endogenous RNA (ceRNA) networks in LUAD progression.MethodsBy analyzing the RNA-seq data from different platforms, we recognized the differentially expressed genes (DEGs) of each platform and screened out the top 20 hub IRGs related to immune responses. Then, we applied the CIBERSORT algorithm to explore the landscape of tumor-infiltrating immune cells (TILs) in LUAD and their connection with hub genes. Next, we predicted and validated the upstream miRNAs and lncRNAs according to their expression and prognostic roles. Finally, we constructed and validated an immune-related ceRNA network by co-expression analysis.ResultsA total of 71 IRGs were identified among 248 DEGs, which play key roles in immune responses. CIBERSORT analysis showed that six hub genes were closely related to TILs, such as SPP1 and naive B cells (R = −0.17), TEK and resting mast cells (R = 0.37). Stepwise prediction and validation from mRNA to lncRNA, including 6 hub genes, 5 miRNAs, and 9 lncRNAs, were applied to construct a ceRNA network. Ultimately, we confirmed the TMPO-AS1/miR-126-5p/SPP1 and CARD8-AS1/miR-21-5p/TEK as immune-related ceRNA networks in LUAD progression.ConclusionWe elucidated two immune-related ceRNA networks in LUAD progression, which can be considered as immunotherapy targets for this disease.
Oncological Outcomes of Patients With Different Pathological Features of pT3a Renal Tumor: A Systematic Review and Quantitative Synthesis
Authors: Guo Pengju , Wang Yongxing , Han Yili , Wei Dechao , Zhao Jiahui , Li Mingchuan , Jiang Yongguang , Luo Yong 
Published: June 2021

PurposeTo identify the differences in oncological outcomes for patients with different pT3a renal tumor invasion patterns and pathological features.MethodsThe protocol of this study was registered on PROSPERO (CRD42021234475). Relevant studies were identified by searching the PubMed, Cochrane library, Embase, and Web of Science databases. Cancer-specific survival (CSS) was selected as the endpoint. Pooled hazard ratio (HR) and 95% confidence interval (CI) extracted from multivariate Cox models were evaluated to identify the hazard association.ResultsA total of 22 studies, which enrolled 12384 patients were included for quantitative synthesis. Sinus fat invasion (SFI) + perinephric fat invasion (PFI) was associated with inferior CSS compared to SFI only (p = 0.02). Comparable CSS was observed between SFI and PFI (p = 0.57). SFI ± PFI showed inferior CSS compared to PFI only (p = 0.0002). The presence of pelvicalyceal system invasion significantly increased the risk of cancer-specific mortality (p = 0.0005). Renal vein invasion (RVI) indicated poor oncological outcomes in terms of CSS (p = 0.002). The concomitant RVI and fat invasion (FI) significantly increased the risk of deterioration of CSS compared to RVI or FI (p &lt; 0.0001). Multiple invasion patterns translated into a significantly decreased CSS (p &lt; 0.0001). Aggressive tumor behavior, including lymph node involvement (p = 0.006), distant metastases (p &lt; 0.00001), sarcomatoid differentiation (p &lt; 0.0001), necrosis (p &lt; 0.0001), Fuhrman grade III or IV (p &lt; 0.0001), positive margin (p &lt; 0.0001), and tumor size &gt;7cm (p &lt; 0.0001) were the predictors of inferior CSS. The lymphovascular invasion (p = 0.67) was indolent in terms of CSS.ConclusionThis study confirmed the heterogenicity of pT3a renal tumors. Multiple invasion patterns could translate into a significantly decreased CSS, and SFI should not be merged in the SFI + PFI group. The presence of PSI or RVI could significantly increase the risk of cancer-specific mortality. Lymph node involvement, distant metastases, sarcomatoid differentiation, necrosis, high Fuhrman grade, positive margin, and size &gt;7cm were the predictors of inferior CSS. A precise-risk grade of CSS for different invasion patterns including comprehensive combinations may be useful for the further refinements of the TNM system.Systematic Review RegistrationThe current study was registered on PROSPERO, and the registration numbers is CRD42021234475.
The PREgnancy and FERtility (PREFER) Study Investigating the Need for Ovarian Function and/or Fertility Preservation Strategies in Premenopausal Women With Early Breast Cancer
Authors: Blondeaux Eva , Massarotti Claudia , Fontana Valeria , Poggio Francesca , Arecco Luca , Fregatti Piero , Bighin Claudia , Giannubilo Irene , Ruelle Tommaso , Razeti Maria Grazia , Boni Luca , Anserini Paola , Del Mastro Lucia , Lambertini Matteo 
Published: June 2021

BackgroundOffering ovarian function and/or fertility preservation strategies in premenopausal women with newly diagnosed breast cancer candidates to undergo chemotherapy is standard of care. However, few data are available on uptake and main reasons for refusing these options.MethodsThe PREFER study (NCT02895165) is an observational, prospective study enrolling premenopausal women with early breast cancer, aged between 18 and 45 years, candidates to receive (neo)adjuvant chemotherapy. Primary objective is to collect information on acceptance rates and reasons for refusal of the proposed strategies for ovarian function and/or fertility preservation available in Italy.ResultsAt the study coordinating center, 223 patients were recruited between November 2012 and December 2020. Median age was 38 years (range 24 – 45 years) with 159 patients (71.3%) diagnosed at ≤40 years. Temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) was accepted by 58 out of 64 (90.6%) patients aged 41-45 years and by 151 out of 159 (95.0%) of those aged ≤40 years. Among patients aged ≤40 years, 57 (35.8%) accepted to access the fertility unit to receive a complete oncofertility counseling and 29 (18.2%) accepted to undergo a cryopreservation technique. Main reasons for refusal were fear of delaying the initiation of antineoplastic treatments and contraindications to the procedure or lack of interest in future childbearing. Patients with hormone-receptor positive breast cancer had a tendency for a higher acceptance rates of ovarian function and/or fertility preservation strategies than those with hormone-receptor negative disease.ConclusionsMore than 90% of premenopausal women with early breast cancer, and particularly those with hormone receptor-positive disease, were concerned about the potential risk of chemotherapy-induced premature ovarian insufficiency and/or infertility and accepted GnRHa administration. Less than 1 out of 5 women aged ≤40 years accepted to undergo cryopreservation strategies.
Libertad, pasiones y racionalidad: una perspectiva desde la teoría de los tres entornos
Authors: Duque Laura , Echeverría Ezponda Javier 
Published: June 2021

En el marco de la Lección inaugural organizada en el año 2019 por el Programa de Filosofía de la Universidad del Quindío, y del Seminario en Ciencia, Tecnología y Sociedad (CTS) del Grupo de Investigación SOFOS, tuvimos como invitado al profesor Javier Echeverría Ezponda.[1] En su libro Entre cavernas: de Platón al cerebro, pasando por Internet, el profesor Echeverría establece la teoría de los tres entornos: ésta consiste en que los seres humanos vivimos en un mundo que nos ofrece los siguientes entornos: 1. Entorno natural: la biosfera. 2. Entorno social: las ciudades, la polis, y 3. Entorno del espacio electrónico: Internet. la luz de la teoría de los tres entornos, y tomando como foco de conversación el tercero, se realizó la siguiente entrevista.
Revoluciones modernas y sus historias encarnadas en agentes políticos
Authors: Cardenas Maldonado Carlos Humberto 
Published: June 2021

La filosofía política de Hannah Arendt resulta ser, desde diferentes lecturas elaboradas por sus críticos y seguidores, un estudio social (filosófico) marcado por desventajas y también por aciertos en sus posturas sancionatorias a las restricciones de expresión en los escenarios propios de las polis actuales, donde existe la oportunidad de manifestar una idea, por caprichosa que esta sea, de vida de una ciudad, de ser en el mundo de la actividad política.

El siguiente escrito es una lectura más sobre dos de los acontecimientos que marcaron diferencia en su ejercicio teórico, en tanto le valieron como soporte a los eventos históricos que darían paso al periodo moderno: el periodo de las revoluciones de Francia y de Estados Unidos. Siendo precisos, el interés de este documento parte de los levantamientos sociales que dieron vida a estas dos revoluciones que dejaron huella en la historia de Occidente y en quienes dieron su vida a ambos sucesos, sin detallar en uno u otro agente político en particular. Finalmente, se hará mención a los errores en los que incurrió Arendt y que la llevaron a imprecisiones de orden histórico que le impidieron analizar cada uno de estos sucesos desde una perspectiva histórica, y sí desde las ansias teóricas especulativas, como el hecho de observar una revolución bien lograda y otra mal ejecutada.
Revealing How Coca Cola Successfully Broke into Indonesia Market with a Coke
Authors: Susilo Donny 
Published: June 2021

Indonesia has been attractive investment destination to many multinational companies since a long time ago, due to its big population, plenty natural resources and cheap labors, including to Coca Cola. This study aims to analyze international market entry and business strategy of Coca Cola when entering Indonesia market. Moreover, this study also aims to identify internal and external factor that affects Coca Cola business in Indonesia by SWOT analysis, resulting in growth strategy recommendation. The result reveals out that Coca Cola came to Indonesia by foreign direct investment at first time, but then decided to expand their distribution all over Indonesia. Therefore, they opened opportunity for franchise. By keeping their secret formula, they can provide differentiation that makes them remains competitive. The strategy adopted by Coca Cola Amatil Indonesia to conquer Indonesia market is transnational strategy, which has characteristics of high in local responsiveness and also high in global integration. Meanwhile, the SWOT analysis suggests that Coca Cola should put priority on market penetration first instead of market development for the time being. Company should focus on sales and distribution in specific market first then explore more market for their product. There are still many possible markets to exploit in Indonesia as well as abroad.
PENGARUH ATTACHMENT STYLE DAN KEPUASAN HUBUNGAN ROMANTISTERHADAP PERILAKU DATING VIOLENCE PADA MAHASISWA UNIVERSITAS BUANA PERJUANGAN KARAWANG ANGKATAN 2016
Authors: Wina Lova Riza  , Arif Rahman Hakim  , Lulu Lutfiah Damayanti  
Published: June 2021

The phenomenon of dating violence is often encountered and shows a number that continues to increase every year. This can affect individual satisfaction in their romantic relationships. This study aims to examine the effect of attachment style and romantic relationship satisfaction toward dating violence behavior. The subjects in this study were students of University Buana Perjuangan Karawang 2016. This study used a quantitative approach with snowball sampling techniques. The sample used was 251 from 936 students. The data analysis technique used is multiple linear regression with an error rate of 5%. The research instrument used three Likert scale questionnaire such as the Experiences in Close Relationships-Revised (ECR-R) questionnaire, the Relationship Assessment Scale, and the Conflict Tactics Scale. The results of the research obtained a significant value of 0.053; p>0.05 indicates that there is no influence between attachment style and romantic relationship satisfaction toward dating violence behavior. Keywords: Attachment style, dating violence, romantic relationship satisfaction, student dating.
Fenomena kekerasan dalam pacaran sering banyak dijumpai dan menunjukkan angka yang terus meningkat setiap tahunnya. Hal ini dapat berpengaruh pada kepuasan individu dalam menjalani hubungan romantisnya. Penelitian ini bertujuan untuk menguji pengaruh attachment style dan kepuasan hubungan romantis terhadap perilaku dating violence. Subjek pada penelitian ini adalah Mahasiswa Universitas Buana Perjuangan Karawang angkatan 2016. Penelitian ini menggunakan pendekatan kuantitatif dengan teknik pengambilan snowball sampling. Sampel yang digunakan sebanyak 251 dari 936 mahasiswa. Teknik analisis data yang digunakan adalah regresi linear berganda dengan taraf kesalahan 5%. Instrumen penelitian menggunakan tiga kuesioner skala likert, yaitu kuesioner Experiences in Close Relationships-Revised (ECR-R), Relationship Assessment Scale, dan Conflict Tactics Scale. Hasil penelitian diperoleh nilai signifikan 0,053; karena p > 0,05 menunjukkan bahwa tidak terdapat pengaruh antara attachment style dan kepuasan hubungan romantis terhadap perilaku dating violence. Kata Kunci: Attachment style, dating violence, kepuasan hubungan romantis, mahasiswa berpacaran.
Manajemen Stres Istri yang Melangsungkan Pernikahan Dini
Authors: Fitria Cut Intan , Yusmami  , Marimbun  
Published: June 2021

Pernikahan yang dilakukan pada saat berumur 16 tahun bagi perempuan dan 19 tahun bagi laki-laki tanpa adanya kesiapan psikis maupun materi disebut dengan pernikahan dini. Pernikahan dini dapat menimbulkan berbagai masalah secara psikologis, sosial dan ekonomi yang dapat menimbulkan stres. Tujuan penelitian ini untuk mendeskripsikan manajemen stres istri yang melangsungkan pernikahan dini di Desa Beusa Meranoe Kecamatan Peureulak. Penelitian ini menggunakan metode studi kasus dengan pendekatan studi kasus. Pengumpulan data diperoleh dari hasil observasi dan wawancara. Informan penelitian adalah dua istri yang menikah di usia dini, suami dan orang tua yang bersangkutan. Hasil penelitian menunjukkan bahwa upaya yang dilakukan istri dalam manajemen stres adalah berpikir positif, memikirkan hal-hal yang disenangi, mengontrol keadaan, melakukan kegiatan-kegiatan yang disenangi, meminta support dari keluarga, dan bersabar.