bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1
Authors: Qin Linghui , Sun Xiaosong , Zhou Fei , Liu Cheng 
Published: June 2021

Abstract
Background
Circular RNA low-density lipoprotein receptor-related protein 6 (circLRP6) is considered as an oncogene in many types of cancers. However, the function and mechanisms of circLRP6 in prostate cancer (PCa) tumorigenesis remain largely undefined.

Methods
Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were conducted to assess the expression of circLRP6, microRNA (miR)-330-5p, and nuclear receptor binding protein 1 (NRBP1). Cell counting kit-8 (CCK-8), colony formation, 5-ethynyl-2’-deoxyuridine (EDU) incorporation, flow cytometry, transwell, wound healing, and western blot assays were performed to detect cell proliferation, apoptosis, and metastasis in vitro. Subcutaneous tumor growth was observed in nude mice to investigate the role of circLRP6 in vivo. The targeting relationship between miR-330-5p and NRBP1 or circLRP6 was verified using dual-luciferase reporter, pull-down, and RNA immunoprecipitation (RIP) assays. Immunohistochemistry was employed to test relative protein expression.

Results
CircLRP6 was highly expressed in PCa tissues and cells, knockdown of circLRP6 impaired PCa cell growth and metastasis in vitro by affecting cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Mechanistic studies showed that circLRP6 could competitively bind with miR-330-5p to prevent the degradation of its target gene NRBP1. Rescue assay suggested that miR-330-5p inhibition reversed the inhibitory effects of circLRP6 knockdown on PCa cell growth and metastasis. Moreover, overexpression of miR-330-5p suppressed PCa progression via NRBP1. Notably, tumor formation assay indicated that circLRP6 silencing impeded tumor growth and EMT in vivo.

Conclusion
Our findings demonstrated that circLRP6 promoted PCa tumorigenesis and metastasis through miR-330-5p/NRBP1 axis, suggesting a potential therapeutic target for PCa.
Improved naive Bayes classification algorithm for traffic risk management
Authors: Chen Hong , Hu Songhua , Hua Rui , Zhao Xiuju 
Published: June 2021

AbstractNaive Bayesian classification algorithm is widely used in big data analysis and other fields because of its simple and fast algorithm structure. Aiming at the shortcomings of the naive Bayes classification algorithm, this paper uses feature weighting and Laplace calibration to improve it, and obtains the improved naive Bayes classification algorithm. Through numerical simulation, it is found that when the sample size is large, the accuracy of the improved naive Bayes classification algorithm is more than 99%, and it is very stable; when the sample attribute is less than 400 and the number of categories is less than 24, the accuracy of the improved naive Bayes classification algorithm is more than 95%. Through empirical research, it is found that the improved naive Bayes classification algorithm can greatly improve the correct rate of discrimination analysis from 49.5 to 92%. Through robustness analysis, the improved naive Bayes classification algorithm has higher accuracy.
Peer-to-peer health promotion interventions among African American men: a scoping review protocol
Authors: Wippold Guillermo M. , Frary Sarah Grace , Abshire Demetrius , Wilson Dawn K. 
Published: June 2021

AbstractBackgroundHealth promotion efforts among African American men have been met with significant challenges and have produced limited results. Interventions that do not align with the values, perspectives, and preferences of African American men often produce less effective results. Research among African American men has provided compelling evidence that these men prefer informal networks of health support. Recent successful health promotion efforts among these men have benefited from peer-to-peer models of implementation. To date, no known scoping or systematic review of peer-to-peer health promotion interventions among African American men has been conducted. The goal of this scoping review is to understand the extent of, design, implementation, and use of peer-to-peer interventions to promote health, improve quality of life, and prevent disease among African American men.MethodsA review of the literature will be performed in PubMED, EMBASE, PsycInfo, CINAHL, and Web of Science. The development of this protocol was guided by the work of Arksey and O’Malley and the PICOS statement. Reporting will be guided by the PRISMA-ScR checklist. Eligible studies include those testing the effects of a peer-to-peer health promotion intervention targeting African American men. A comparison group will not be required. For the purposes of the current review, “peers” will be limited to other African American men. An initial screening of the titles and abstracts of potentially eligible studies will be completed by two independent reviewers. The full text of records that appear to meet the eligibility criteria will be accessed and further screened. Data will then be extracted and collected using a custom Microsoft Excel spreadsheet. Extracted data will include authors’ name and publication year, target health issue(s), design of the intervention, components of the intervention, peer-led components of the intervention, peer role, length and type of training for peer leaders, intervention duration, frequency of the intervention, study design and number of participants, and main outcomes. Finally, results will be presented in table format and summarized in text format.DiscussionResults will have implications for the design, implementation, and evaluation of health promotion interventions among African American men.Systematic review registrationPROSPERO CRD42020198664
Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice
Authors: Keskin Isil , Ekhtiari Bidhendi Elaheh , Marklund Matthew , Andersen Peter M. , Brännström Thomas , Marklund Stefan L. , Nordström Ulrika 
Published: June 2021

AbstractThe deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms that cause the spreading of template-directed aggregation of specific disease-associated proteins. In transgenic (Tg) mouse models of superoxide dismutase-1 (SOD1)-linked amyotrophic lateral sclerosis (ALS), inoculation of minute amounts of human SOD1 (hSOD1) aggregates into the spinal cord or peripheral nerves induces premature ALS-like disease and template-directed hSOD1 aggregation that spreads along the neuroaxis. This infectious nature of spreading pathogenic aggregates might have implications for the safety of laboratory and medical staff, recipients of donated blood or tissue, or possibly close relatives and caregivers. Here we investigate whether transmission of ALS-like disease is unique to the spinal cord and peripheral nerve inoculations or if hSOD1 aggregation might spread from the periphery into the central nervous system (CNS). We inoculated hSOD1 aggregate seeds into the peritoneal cavity, hindlimb skeletal muscle or spinal cord of adult Tg mice expressing mutant hSOD1. Although we used up to 8000 times higher dose—compared to the lowest dose transmitting disease in spinal cord inoculations—the peripheral inoculations did not transmit seeded aggregation to the CNS or premature ALS-like disease in hSOD1 Tg mice. Nor was any hSOD1 aggregation detected in the liver, kidney, skeletal muscle or sciatic nerve. To explore potential reasons for the lack of disease transmission, we examined the stability of hSOD1 aggregates and found them to be highly vulnerable to both proteases and detergent. Our findings suggest that exposed individuals and personnel handling samples from ALS patients are at low risk of any potential transmission of seeded hSOD1 aggregation.
Female (Under) Representation in Exercise Thermoregulation Research
Authors: Hutchins Kate P. , Borg David N. , Bach Aaron J. E. , Bon Joshua J. , Minett Geoffrey M. , Stewart Ian B. 
Published: June 2021

Abstract
Background
Despite an increasing rate of women participating in professional sports, emergency services, and military settings where they are exposed to exertional heat stress, our understanding of female thermoregulation and the detrimental effects of heat on women’s performance, especially regarding the menstrual cycle, is limited. This review aimed to quantify the representation of women in exercise thermoregulation research between 2010 and 2019 and the frequency that these articles reported details pertaining to female participants’ menstrual cycle to determine the volume of novel research that is directly relevant to this growing population.

Methods
Original exercise thermoregulatory studies published in three major sports medicine databases (PubMed, MEDLINE, and SPORTDiscus) between 2010 and 2019 were surveyed. Articles were screened to determine the number of female and male participants in the study and whether studies involving women reported menstrual orientation or phase. Research involving healthy adult participants and an exercise protocol with a thermoregulatory outcome measure were included in the review.

Results
A total of 1407 articles were included in the review, involving 28,030 participants. The annual representation of women ranged from a mean of 11.6% [95% credible interval (CI); 9.2, 14.3] to 17.8% [95% CI; 15.2, 20.6] across the 10 years, indicating studies predominantly included men. Nonetheless, there was a small statistical increase in the overall proportion of women, with a mean overall proportion change of 0.7% [95% CI; 0.2, 1.2] per year. The increase appeared to be driven by a reduction in the number of studies including only men, rather than studies including more women alongside men, or increased women-only studies. Less than one third of articles involving women reported the menstrual orientation of participants and less than one quarter reported both menstrual orientation and phase.

Summary/Conclusion
This study shows that women were proportionally underrepresented in exercise thermoregulation research during the past decade and the majority of studies did not report menstrual cycle details of female participants. Researchers should consider including women in future work where their inclusion could contribute meaningful data that enhance the evidence-based and ultimately improves our comprehension of women’s thermal physiology.
In silico studies of bioactive compounds from selected African plants with inhibitory activity against nitric oxide synthase and arginase implicated in asthma
Authors: Umar Haruna Isiyaku , Saliu Tolulope Peter , Josiah Sunday Solomon , Ajayi Adeola , Danjuma Jamilu Bala 
Published: June 2021

AbstractBackgroundIt is a known fact that arginine is a common substrate for arginase and nitric oxide synthase (NOS). However, an imbalance between both enzymes could lead to a change in airway responses. Reports suggest that increased activities of both enzymes could lead to airway hyper-responsiveness. Thus, the requests for NOS inhibitors that can also inhibit arginase as the elevated activities of both enzymes have detrimental consequence on airways in asthma. Bioactive compounds fromAzadirachta indica,Crinum glaucum, andMangifera indicaare documented for anti-inflammatory, immunomodulatory, anti-histaminic, smooth-muscle relaxants, and anti-allergic potentials. However, the mechanisms of action of these bioactive compounds in conferring the aforementioned protections are not well characterized. The objective of this present study is to assess in silico inhibitory potentials of these bioactive compounds against NOS and arginase via binding at their active sites. The crystal structures of NOS and arginase were retrieved from the protein database, while the bioactive compounds were retrieved from PubChem. Drug-likeness of the selected bioactive compounds was assessed using DruLiTo software. The successful compounds were docked with active sites of enzymes using AutoDock Vina docking software, and the docked complexes were analyzed using LigPlot and protein-ligand profiler web server.ResultsThe findings of the study revealed that the bioactive compounds fromA.indica,C.glaucum, andM. indicawere able to interact with the active sites of NOS and arginase with the exception of gallic acid (fromM.indica) and nimbandiol (fromA.indica); these compounds showed differential binding energies (kcal/mol) and a number of them had higher binding energies thanl-arginine when docked with NOS.ConclusionConclusively, the in silico analysis proposes that these compounds could prove to be probable anti-asthmatic drugs.
Gender differences in patients presenting with non-ST segment elevation myocardial infarction in the STAR registry
Authors: Kinsara Abdulhalim Jamal , Ismail Yasser M. 
Published: June 2021

Abstract
Background
In most acute coronary artery (ACS) related literature, the female gender constitutes a smaller proportion. This study is based on gender-specific data in the Saudi Acute Myocardial Infarction Registry Program (STARS-1 Program). A prospective multicenter study, conducted with patients diagnosed with ACS in 50 participating hospitals.

Results
In total, 762 (34.12%) patients were diagnosed with non-ST segment elevation myocardial infarction. Of this group, only 164 (21.52%) were women. The mean age (64.52 ± 12.56 years) was older and the mean body mass index (BMI) was higher (30.58 ± 6.23). A significantly proportion was diabetic or hypertensive; however, a smaller proportion was smoking. Hyperlipidemia was present in 48%. The history of angina/MI/stroke and revascularization was similar, except for renal impairment. The presentation was atypical as only 70% presented with chest pain, and the rest with shortness of breath or epigastric pain. At presentation, the female group were more tachycardiac, had higher blood pressure, and a higher incidence of being in class 11-111 Killip heart failure. Only 32% had a normal systolic function, and the majority had either mild or moderate systolic dysfunction.
In particular, the rate of percutaneous coronary intervention was similar. The in-hospital mortality was similar (5%), with more women diagnosed with atrial fibrillation and heart failure at follow-up.

Conclusions
Women had a higher prevalence of risk factors affecting the presentation and morbidity but not mortality. Improving these risk factors and the lifestyle is a priority to improve the outcome and decrease morbidity.
Dural carotid-cavernous fistulas: our experience with endovascular management
Authors: Prasad Surya Nandan , Singh Alok Pratap , Kanaujia Vikas , Singh Vivek , Phadke Rajendra Vishnu , Sharma Kumudini 
Published: June 2021

Abstract
Background
Indirect carotid-cavernous fistulas (CCF) are dural arteriovenous fistula of the cavernous sinus and generally present with ocular symptoms. High index of clinical suspicion and radiological work up is required for diagnosis, and treatment is primarily endovascular embolization. We present our experience in diagnosis and management of indirect CCF along with technical evolution to perform embolization and different vascular accesses for difficult anatomy.

Results
Among a total of 20 indirect CCF cases who were treated with embolization in our department from 2013 to 2020, five (25%) were type C and 15 (75%) were type D. Seven were treated with trans-arterial access only, 11 were treated by transvenous access only, and two were treated by taking both transvenous and trans-arterial access. No recurrence was seen in angiographically cured patients. Out of seven patients who suffered various grades of visual deficit, five recovered completely and two had fixed visual deficit. Third and sixth cranial nerve palsy persisted in two patients even after CCF embolization.

Conclusion
Indirect CCF is a treatable cause of troublesome ocular symptoms. Endovascular embolization is preferred treatment with excellent short- and long-term outcome. The embolization becomes difficult and challenging in cases where the conventional vascular access to the cavernous sinus is occluded.
Multi-sensor data collection and fusion using autoencoders in condition evaluation of concrete bridge decks
Authors: Pashoutani Sepehr , Zhu Jinying , Sim Chungwook , Won Kwanghee , Mazzeo Brian A. , Guthrie W. Spencer 
Published: June 2021

AbstractThis paper presents a multi-sensor data collection and data fusion procedure for nondestructive evaluation/testing (NDE/NDT) of a concrete bridge deck. Three NDE technologies, vertical electrical impedance (VEI), ground-penetrating radar (GPR), and high-definition imaging (HDI) for surface crack detection, were deployed on the bridge deck. A neural network autoencoder was trained to quantify the relationship between VEI and GPR results using the data collected at common positions. This relationship was then used for fusion of VEI and GPR data to increase the reliability and spatial resolution of the NDE measurements and to generate a data-fused condition map that showed novel characteristics. Threshold values for VEI and GPR tests were obtained and used to determine the color scale in the fused map. Surface cracks identified from HDI show reasonable agreement with the deterioration areas on the data-fused condition map. Chloride concentration measurements on sound and deteriorated areas of the deck were consistent with the NDE results.
Zur Entdeckung eines Faustkeiles und anderen paläolithischen Funden aus Bettingen
Authors: Braun Ingmar M. , Jagher Reto 
Published: June 2021

In den letzten Jahren konnten in der Landgemeinde Bettingen dank zahlreicher Feldbegehungen mehrere steinzeitliche Siedlungsstellen lokalisiert werden, die ins Neolithikum datieren. Anlässlich des Baus des neuen Sendeturms auf der St. Chrischona wurde überdies ein Fragment eines Mammutstosszahns gefunden. Dies blieb bis 1990 der einzige paläolithische Fund aus der Gemeinde Bettingen. Damals fand der Verfasser auf einem Feld einen Levallois-Kern und 1998 einen Faustkeil - beides ebenfalls Zeugnisse aus dem Paläolithikum. Vor allem der Faustkeil ist von überregionaler Bedeutung, da er ein sehr seltenes Fundstück darstellt.
Die technologische Beurteilung des Levallois-Kerns von Bettingen konnte ein für die Levallois-Technik unorthodoxes Vorgehen nachweisen. Gut vergleichbare Parallelen zu dem in Bettingen angewandten Produktionsschema sind bis heute keine bekannt.
Zur Entstehung von Gehniveaus in sandig-lehmigen Ablagerungen
Authors: Rentzel Philippe , Narten Gesa-Britt 
Published: June 2021

Ausgehend von zwei Experimentalreihen werden zuerst die Auswirkungen menschlicher Begehung auf sandig-lehmige Oberflächen vorgestellt. Die naturwissenschaftliche Auswertung der Versuche gestattet dabei Aussagen über Art, Intensität und Tendenz der Gefügeveränderungen in feuchten und trockenen Sedimenten.
Der zweite Teil der Arbeit behandelt gut konservierte archäologische Gehniveaus, deren Merkmale mit den Resultaten aus den Experimentalreihen verglichen werden.
Education and training to support physiotherapists working in dementia care: a scoping review protocol
Authors: O'Sullivan Trish , Foley Tony , McVeigh Joseph G. , Timmons Suzanne 
Published: June 2021

Background: The care of people with dementia is of global concern. Physiotherapeutic intervention can be of benefit to patients with dementia. Physiotherapists can play a role in assessment, falls prevention, pain management and gait re-education. Dementia care forms a significant part of the workload of a physiotherapist. However, there is a paucity of evidence on what constitutes effective education and training for physiotherapists working in dementia care. Objective: This scoping review aims to explore and map the evidence on education and training for physiotherapists working in dementia care. Inclusion criteria: Studies that explore dementia training and/or education for physiotherapists or for multidisciplinary teams, in which physiotherapists have been included. Studies that explore student physiotherapy training will also be considered. Qualitative, quantitative, mixed methods studies, case studies and observational studies will be included. Methods: This scoping review will follow the Joanna Briggs Institute (JBI) methodology for scoping reviews. Databases to be searched as part of this review include: Medline, SocINDEX, CINAHL and, PsycINFO, with no limitation on publication date. Google Scholar and Open-Grey will be searched for grey literature, limited to the first 100 searches. Titles and abstracts will be screened for inclusion and identified full texts reviewed independently by two reviewers. Data will be extracted using a draft data extraction tool based on the JBI data extraction tool. A chronological narrative synthesis of the data will outline how the results relate to the aims and objective of this scoping review.
Runaway: Gregory Bateson, the Double Bind, and the Rise of the Ecological Consciousness, Andrew Chaney (2017)
Authors: Ward Joel 
Published: June 2021

Review of: Runaway: Gregory Bateson, the Double Bind, and the Rise of the Ecological Consciousness, Andrew Chaney (2017)
Chapel Hill, NC: University of North Carolina Press, 304 pp.,
ISBN 978-1-46963-173-8, h/bk, $32.95, Kindle, $14.74
Eu não sei dizer
Authors: Osses Patricia Andrea Soto 
Published: June 2021

Neste ensaio teórico-visual o entendimento do feminino - na sua percepção como falta e silêncio - a partir da literatura de Marguerite Duras entra em relação com reflexões espaciais e imagens realizadas durante período de pesquisa na França. Tendo como ponto de partida a obra literária e cinematográfica de duras, especialmente o roteiro do filme “Hiroshima meu amor” e a cidade de Nevers, a realização dos trabalhos visuais surgem no percorrer de seus lugares literários, considerando aspectos locais, elementos de sobreposição entre realidade e ficção e uma ideia de reconstrução do lugar a partir da experiência. Visualidade e literatura se tornam diferentes formas de vivenciar tanto um texto como um lugar.
Lability in Old English Verbs: Chronological and Textual Distribution
Authors: García García Luisa , Ruiz Narbona Esaúl 
Published: June 2021

Abstract
Present-Day English has an unusually high number of labile verbs, such as melt or burn, both cross-linguistically and with respect to genetically related languages. Comparison among early Germanic languages has allowed researchers to detect an incipient favouring of labile coding already in Old English, where it is more frequent than in any other language of this group (Hermodsson 1952) and replaces causative coding in a considerable proportion of former causative verb pairs (van Gelderen 2011; García García 2020). This article attempts to map the chronological and textual distribution of labile verbs between the seventh and the eleventh centuries CE in order to explore how lability develops throughout the Old English period. Old English labile verbs coming from Germanic causative oppositions are the sample on which we base our study. The choice ensures that the verbs in question were originally not labile and underwent a process of labilization in (pre-)Old English. Some of the questions addressed in the study are: Can a tendency towards labilization in Old English be confirmed by internal evidence, as it arguably can by external comparison with other Germanic languages? Can an increase in lability be detected in English before French influence was effective? Does it show any restrictions by genre or individual text?