bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putative Blood Somatic Mutations in Post-Traumatic Stress Disorder-Symptomatic Soldiers: High Impact of Cytoskeletal and Inflammatory Proteins
Authors: Sragovich Shlomo , Gershovits Michael , Lam Jacqueline C.K. , Li Victor O.K. , Gozes Illana 
Published: January 2021

Background: We recently discovered autism/intellectual disability somatic mutations in postmortem brains, presenting higher frequency in Alzheimer’s disease subjects, compared with the controls. We further revealed high impact cytoskeletal gene mutations, coupled with potential cytoskeleton-targeted repair mechanisms. Objective: The current study was aimed at further discerning if somatic mutations in brain diseases are presented only in the most affected tissue (the brain), or if blood samples phenocopy the brain, toward potential diagnostics. Methods: Variant calling analyses on an RNA-seq database including peripheral blood samples from 85 soldiers (58 controls and 27 with symptoms of post-traumatic stress disorder, PTSD) was performed. Results: High (e.g., protein truncating) as well as moderate impact (e.g., single amino acid change) germline and putative somatic mutations in thousands of genes were found. Further crossing the mutated genes with autism, intellectual disability, cytoskeleton, inflammation, and DNA repair databases, identified the highest number of cytoskeletal-mutated genes (187 high and 442 moderate impact). Most of the mutated genes were shared and only when crossed with the inflammation database, more putative high impact mutated genes specific to the PTSD-symptom cohorts versus the controls (14 versus 13) were revealed, highlighting tumor necrosis factor specifically in the PTSD-symptom cohorts. Conclusion: With microtubules and neuro-immune interactions playing essential roles in brain neuroprotection and Alzheimer-related neurodegeneration, the current mutation discoveries contribute to mechanistic understanding of PTSD and brain protection, as well as provide future diagnostics toward personalized military deployment strategies and drug design.
CONTROL OF ADULT AND LARVAL AEDES ALBOPICTUS WITH ATTRACTIVE TOXIC SUGAR BAITS (ACTIVE INGREDIENT: CINNAMON-SESAME OIL) IN NORTHEASTERN FLORIDA
Authors: Traore Mohamed M. 
Published: January 2021

Because traditional methods of mosquito control using insecticides has produced resistance, new methods that are environmentally friendly, sustainable and cost effective have been sought. One method, attractive toxic sugar baits (ATSB), uses the biological requirements, ecology, and behavior of mosquitoes to attract and kill them. In this study, the efficacy of a new ATSB active ingredient, microencapsulated cinnamon oil-plus-sesame oil, was tested in the laboratory and field against Aedes albopictus (Skuse) and the effect on non-target organisms was evaluated. The average mortality among groups of 20 third instar larvae after exposure to microencapsulated cinnamon-sesame oil ATSB in the laboratory for 48 h was high. Mortality at 10% and 1% ATSB concentration was 95.8% and 90.0% respectively and began to drop off (to 65%) at 0.1%. After application of the ATSB in the field, on day 11 of the study, the adult Ae. albopictus populations at the experimental site dropped significantly compared to pre-treatment levels and to the untreated control population. The differences between the control and the treated sites remained significant until the end of the study period on day 28. If used in accordance with label instructions and applied on non-flowering green vegetation, the potential impact on non-target populations was negligible with the exception of non-biting midges (Chironomidae). The synergistic effect of the attracting and killing adult mosquitoes as well as wash-off into part of the breeding sites with larvicidal cinnamon oil-plus-sesame oil product likely explains the high mortality of this ATSB formulation.
LABORATORY TOXICITY OF MOSQUITO ADULTICIDES TO THE ASIAN TIGER MOSQUITOES, AEDES ALBOPICTUS AND THE HONEY BEES, APIS MELLIFERA
Authors: Sanchez-Arroyo Hussein 
Published: January 2021

Aedes albopictus and Apis mellifera were exposed to six insecticide active ingredients and five commercial insecticide formulations by topical application and insecticide-impregnated paper strips respectively to determine the differential toxicity and the potential use of the two methods in insecticide resistance monitoring surveys. By topical application deltamethrin was the most toxic active ingredient (LD 50 = 0.018 µg/g) for Ae. albopictus whereas chlorpyrifos was the least toxic (LD 50 = 0.499 µg/g). For Apis mellifera, the most toxic active ingredients were bifenthrin (LD 50 = 0.047 µg/g) and deltamethrin (LD 50 = 0.055 µg/g) while chlorpyrifos (LD 50 = 0.215 µg/g) and permethrin (LD 50 = 0.287 µg/g) had comparatively low toxicity. When the insecticide-impregnated method was used, Mosquito Mist (a.i. chlorpyrifos) was the most toxic commercial formulation for both Ae. albopictus (LC50 = 0.028 µg/cm2 ) and A. mellifera (LC50 = 0.059 µg/ cm2 ). Duet and DeltaGard showed the least toxicity (LC50 = 2.429 µg/cm 2 and LC50 = 0.491 µg/cm 2 respectively) for Ae. albopictus and DeltaGard was the least toxic to A. mellifera (LC50 = 18.09 µg/cm2 ).
When using the topical application method with insecticide active ingredients, more than 3 times permethrin and deltamethrin were required to obtain the same mortality rate in A. mellifera as in Ae. albopictus. However, chlorpyrifos was more toxic for A. mellifera than for Ae. albopictus. In the insecticide-impregnated paper-strip method with commercial insecticide formulations, more than 36 times of DeltaGard was required to obtain the same mortality rate in A. mellifera as in Ae. albopictus. Even though the Mosquito Mist is the most toxic commercial formulation for both insect species, A. mellifera were more than 2 times tolerant to this insecticide compared to Ae. albopictus.
The study concludes the active ingredient deltamethrin or its commercial formulation DeltaGard is the best among tested insecticides to control Ae. albopictus with minimal effects to A. mellifera.
Aliran Fluida Laminer Pada Pipa Non Horizontal
Authors: Basuki Imam , Susanto Fredy 
Published: January 2021

aliran fluida dalam pipa nonhorizontal merupakan aliran dalam koordinat silindrikal merupakan aliran yang berkembang secara penuh dalam arah subu z. dengan menerapkan prinsip-prinsip hokum kekekalan masa dan momentum, serta berpendekatan pada teorema gauss serta menentukan kondisi batas teoritisnya, maka aplikasi persamaan navier stoke menghasilkan gambaran nilai laju arah aliran fluida berkembang penuh dalam pipa, profile aliran berupa profil aliran hiperbolik dalam pipa alir, dan laju rata-rata volume fluida yang memiliki kekuatan laju dalam nilai kuadrat 4 nilai jari-jari pipa alirnya (a^4 ).
PENGARUH PEMBERIAN ABU JANJANG KELAPA SAWIT TERHADAP PERTUMBUHAN DAN PRODUKSI JAGUNG MANIS (Zea mays saccharata sturt) DI LAHAN GAMBUT
Authors: Marlina  
Published: January 2021

Penelitian dengan judul Pengaruh Pemberian Abu Janjang Kelapa Sawit (AJKS) Terhadap Pertumbuhan dan Produksi Jagung Manis di Lahan Gambut ini dilaksanakan dari Bulan Oktober 2017 sampai Bulan Maret 2018 di parit 3 Kelurahan Tembilahan Hulu, Kecamatan Tembilahan Hulu Kabupaten Indragiri Hilir, analisis tanah dan AJKS dilakukan di Laboratorium Institut Pertanian Bogor. Tujuan dari Penelitian ini untuk mengetahui Pengaruh Pemberian AJKS Terhadap Pertumbuhan Dan Produksi Tanaman Jagung Manis (Zea mays saccharata sturt)) Di Lahan Gambut. Rancangan yang digunakan adalah Rancangan Acak Kelompok Non Faktorial yang terdiri dari 4 perlakuan dengan tiga kelompok/ulangan. Perlakuan yang diberikan adalah AJKS yang terdiri dari 4 taraf, yaitu: : A0: 0 kg/ha, A1: 500 kg/ha, A2: 1000 kg/ha, A3: 1500 kg/ha. Berdasarkan hasil penelitian yang telah dilakukan, terjadi pengaruh nyata antara perlakuan pemberian AJKS terhadap semua parameter yang diamati kecuali pada jumlah tongkol pertanaman. Pemberian AJKS 1500 kg/ha memberikan hasil tertinggi pada semua parameter yang diamati kecuali pada jumlah tongkol.
PEMUPUKAN PADA TANAMAN KARET (Havea Brasiliesis) DI INSTALASI BENIH PERKEBUNAN KUALU PROVINSI RIAU
Authors: Kailani  
Published: January 2021

Karet merupakan salah satu komoditi pertanian yang sangat penting, baik sebagi sumber pendapatan, kesempatan kerja, dan sumber devisa Negara. Indonesia merupakan Negara dengan luas areal perkebunan karet terbesar di dunia 3,4 hektar di ikuti Thailand 2,6 juta hektar dan Malaysia 1,02 juta hektar. Penelitian ini dilakukan Tempat dan waktu Penelitian/magang dilaksanakandi lahan instansi Benih Perkebunan Kualu Nenas , Kab Kamapr. Dilakukan pada tangal 08 Januari sampai dengan 08 Februari 2020 di Pekanbaru. Metode pelaksanaan Pada pelaksanaan kegiatan magang,penulis diberi kesempatan berkerja secara langsung dilapangan sebagai karyawan harian lepas dan mengikuti semua kegiatan selama 1 bulan. Pemupukan menurut pengertian khusus ialah pemberian bahan yang dimaksudkan untuk menyediakan hara bagi tanaman. Umum nya pupuk diberikan dalam bentuk padat ataupun cair melalui tanah yang di serap oleh akar tanaman. pemupukan yang dianjurkan oleh Balai Penelitian Karet Sembawa (2003), yaitu dengan dosis : Urea: 175 gram ph -1 aplikasi -1 , SP-36 : 130 gram ph -1 aplikasi -1 , dan KCl: 150 gram ph -1 aplikasi -1 .
E-Promosi untuk Komunikasi pelanggan di Sektor Minuman: Studi Kopi Kenangan
Authors: Rachmawati Eva , Hurriyati Ratih , Dewi Dirgantari Puspo 
Published: January 2021

Penelitian untuk mengetahui pengaruh e-promotion pada media sosial terhadap keputusan pembelian konsumen Kopi Kenangan. Variabel yang diteliti yaitu: Personal relevance (X1), Interactivity (X2), Message (X3), dengan variable keputusan pembelian pada konsumen Kopi Kenangan menggunakan model attention, intersert, disire, action. Penelitian ini menggunakan sampel sebanyak 165 responden. Penelitian ini termasuk ke dalam penelitian deskriptif dan verifikatif dengan menggunakan metode non probality sampling. Teknik pengambilan sampel secara accidental sampling, yaitu cara untuk mendapatkan sampel berdasarkan siapa saja konsumen yang kebetulan bertemu pada saat melakukan penelitian. Uji yang digunakan untuk menguji instrumen penelitian berupa uji validitas dan uji realibilitas. Uji hipotesis menggunakan uji F dan uji t, analisis data yang digunakan adalah regresi berganda.Variabel Personal Relevance (X1) memberikan pengaruh terhadap Keputusan Pembelian (Y) pada kopi kenangan. Variabel Interactive (X2) tidak memberikan pengaruh terhadap Keputusan Pembelian Kopi Kenangan. Sedangkan Variabel Message (X3) memberikan pengaruh terhadap Keputusan Pembelian Kopi Kenangan. Variable yang memberikan pengaruh besar terhadap Keputusan Pembalian (Y) adalah variable Personal Relevance.
Kata Kunci: e-promotion, personal relevance, interactivity, message, analisis regresi berganda.
Faktor Penentu Kinerja Keuangan Dan Nilai Perusahaan Sektor Pertambangan Di Bursa Efek Indonesia
Authors: Yusrizal Yusrizal , Suharti Suharti 
Published: January 2021

Salah satu cara untuk meningkatkan kemakmuran perusahaan antara lain dengan meningkatkan nilai perusahaan (firm value). Dimana nilai perusahaan (firm value) akan tergambar dari harga saham perusahaan. Pada umumnya, tingginya nilai perusahaan (firm value) dapat memancing ketertarikan investor untuk melakukan keputusan berinvestasi perusahaan yang dipilih. Hal tersebut dikarenakan perusahaan tersebut dianggap memiliki prospek yang bagus dan menjanjikan untuk jangka panjang. Penelitian ini bertujuan untuk menguji pengaruh kepemilikan manajerial, kepemilikan institusional, Dewan komisaris independen, komite audit dan leverage terhadap kinerja keuangan dan nilai perusahaan. Populasi dalam penelitian ini adalah perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia pada tahun 2013-2018 berjumlah 41 perusahaan. Teknik pengambilan sampel perusahaan yang digunkan yaitu metode purpose sampling, dimana berdasarkan teknik tersebut maka dapat diperoleh sampel dalam penelitian ini sebanyak 37 perusahaan. Teknik analisis yang digunakan yaitu teknik analisis deskriptif dan Path analysis dengan bantuan software Smart PLS. Hasil penelitian ditemukan bahwa variabel kepemilikan manajerial, kepemilikan institusional, dewan komisaris independen, komite audit dan DER tidak berpengaruh secara signifikan terhadap profitabilitas (ROA) perusahaan pertambangan yang terdaftar dibursa efek indonesia selama 2013 sampai dengan 2018. kepemilikan manajerial dan kepemilikan institusional mempunyai pengaruh positif dan signifikan terhadap nilai perusahaan pertambangan yang terdaftar dibursa efek indonesia selama 2013 sampai dengan 2018. Sedangkan dewan komisaris independen, komite audit, DER dan ROA tidak mempunyai pengaruh signifikan terhadap nilai perusahaan pertambangan yang terdaftar dibursa efek indonesia selama 2013 sampai dengan 2018.
DESAFIOS E POLITICAS DE DESENVOLVIMENTO DA CIRCULAÇÃO E DA MOBILIDADE URBANA E RURAL
Authors: Siqueira Ana Cristina Costa , Souza Edson Belo Clemente de 
Published: January 2021

A mobilidade é essencial para que haja a circulação, bem como o deslocamento de pessoas para diversos lugares, principalmente com o aumento do fluxo de veículos e pessoas que as cidades estão observando nos últimos tempos. A falta de mobilidade traz aspectos negativos à população, sendo necessária a transformação dos espaços urbanos com a finalidade de tornar a vida dos moradores com qualidade, intensificando o tempo com relação aos deslocamentos. Dessa forma planos de mobilidade urbana foram instituídos levando gestores das cidades a pensarem medidas para que os impactos negativos sejam minimizados e com isso, tragam fluidez para seus usuários, reduzindo o espaço-tempo em que realizam suas atividades, sejam elas em torno do trabalho, educação ou até mesmo do lazer. Com a importância que o estudo da mobilidade apresenta na sociedade atual, o objetivo deste artigo é analisar, ainda que teoricamente, o papel da mobilidade urbana e rural no contexto atual da sociedade. As interfaces estão contidas na circulação, na (tele)comunicação e nas redes geográficas constituídas. A metodologia utilizada é de caráter bibliográfica, a partir de conceitos e teorias que norteiam a mobilidade no sentido do deslocamento em espaços urbano e rural. Depreende-se, a partir deste estudo, que a mobilidade no atual momento da sociedade capitalista é um tema relevante e deve ser prioridade dos gestores públicos para implementar políticas públicas que assegurem o deslocamento de qualidade de um lugar para o outro.
Aplicación de un instrumento para medir el grado de liderazgo en el hotel Villa Cuba
Authors: Mesa Ramos Darien , Jiménez Valero Bisleivys , Bordón Gómez Yunislay 
Published: January 2021

El turismo es la actividad impulsora de otras actividades económicas y sigue creciendo, sin embargo, en la actualidad no existe el conocimiento y la preparación necesaria en cuanto a la Gestión de la Tecnología y la innovación en los servicios turísticos.
Este trabajo se realizó con el objetivo de medir el grado de liderazgo en la entidad objeto de estudio, para ello se utilizó un instrumento que es una novedad científica y radica en la puesta en práctica de un cuestionario hecho por los profesores del CETUM de la UMCC.
El uso de esta metodología evidenció que el valor percibido del liderazgo es bajo, los trabajadores no son motivados y no se ejerce un buen liderazgo, por lo que no tienen un buen rendimiento, es por ello que es necesario evaluar y proponer medidas y objetivos para mejorar su accionar.
Análisis semiótico de videos en la resolución de problemas de la física
Authors: León Arencibia Ariel , Rodríguez Brito Bárbaro Evelio , Dorvigny González Beatriz de la Caridad 
Published: January 2021

El mundo de hoy está caracterizado por el desarrollo electrónico en las diferentes esferas sociales. Cuba no está exenta a esta situación. Escuelas nuevas, excelentes materiales de estudios y la aplicación de los nuevos programas de la revolución ponen al maestro en condiciones para lograr resultados muy superiores a todo el quehacer precedente. La computadora permite automatizar el procesamiento de datos e inmediatamente presentar los resultados en forma gráfica y de ecuaciones, su empleo en un experimento contribuye a elevar su calidad, por otras razones relacionadas con objetivos fundamentales del proceso de enseñanza aprendizaje de la Ciencia. También el análisis semiótico sobre el texto constituido por la simulación, a partir de la triada de Peirce, origina el fenómeno por el cual un signo da nacimiento a otro signo y, especialmente, un pensamiento da nacimiento a otro pensamiento. En el trabajo se pretende presentar y ejemplificar cómo hacer uso del software Tracker, IDES y GeoGebra con una pequeña descripción desde la semiótica de su significado, permitiendo hacer el análisis de videos relacionados con la vida práctica en el curso Optativo de la Carrera de Licenciatura en Educación. Física, siendo el mismo una herramienta poderosa para el desarrollo del proceso enseñanza aprendizaje de la Física.
Como influyen los ejercicios de flexibilidad y elasticidad para aliviar el estrés en el adulto mayor
Authors: Cabezas Flores Mónica Cabezas , Ochoa Sangurima Vanessa Lucia , Carrasco Coca Orlando Rodrigo , Jara Martínez Ricardo Manolo 
Published: January 2021

La flexibilidad y elasticidad es necesaria para poder recuperar rápidamente la eficacia muscular en cada articulación, poder realizar los movimientos con fluidez, armonía, y amplitud, manteniendo el organismo en constante movimiento para que no exista la pérdida de la misma, los componentes integradores fundamentales de la flexibilidad son la movilidad articular y la elasticidad muscular, la extensión de un movimiento en su mayor o menor amplitud es la responsabilidad de la movilidad articular, es decir, de la admisión de movimientos por parte de la propia articulación y de la elasticidad de músculos y tendones que permiten mayores elongaciones. Stress en inglés, fue introducida por Hans Selye, un médico canadiense (significa "fatiga"), es una reacción fisiológica del organismo en la cual se manifiesta cuando un individuo en su vida cotidiana, reacciona ante un suceso o situación amenazante o agobiante como respuesta natural y necesaria para la supervivencia, no solo las situaciones agresivas, violentas, desfavorables, son causantes de estrés. También lo pueden ser circunstancias agradables, bienvenidas pero muy cargadas de emoción o de tensión como puede ocurrir frente a una mudanza muy deseada, o el casamiento de un hijo, etc. Entre las desfavorables están las muertes, en especial las repentinas, las crisis económicas y sociales, lo que implica vivir con mucha tensión, traumas físicos, emocionales y/o sociales.
The Effect Of Model CRH By Board Reward On Student Learning Outcomes Of Class II In Elementary School
Authors: Khasanah Rahmawatin , Supratno Haris , Siswanto M. Bambang Edi 
Published: January 2021

This study applies the model course review horay (CRH) with the help of media board reward on the theme of learning 6 caring for animals and plants in SDN Jatirejo. The method used is an experimental method in Pre-Experimental Design in the form of Intact-Group Comparison. The subjects of the study were of grade II SDN Jatirejo in academic year 2019/2020. Data collection through observation of learning activities and written tests to measure student learning outcomes before and after being given treatment. The results of data analysis using the t-test formula to determine the effect of treatment in the experimental and control groups. The results of the study using the model course review horay helped by the media reward board were more fun and students were actively learning so that the teacher easily delivered teaching material with a very good category namely the experimental group (11,843 ) > the control group (11,655) which means that there is an influence on the use of the model course review horay with the help of media board reward in the experimental group is greater than conventional learning applied to the control group. The results of this study as a source of information input and consideration for institutions involved in learning theme 6 grade II elementary school.
Altered production of membrane-associated proteins, providing iodine accumulation by thyroid gland, after exposure to endocrine disruptor DDT
Authors: Obernikhin Sergey S. , Yaglova Nataliya V. , Nazimova Svetlana V. , Yaglov Valentin V. 
Published: January 2021

Exposure to endocrine disruptors has a sufficient impact in rise of thyroid disorders. Iodine accumulation by the thyroid is provided by sodium iodide symporter, a glycoprotein, located in the basolateral membrane of thyroid cells. Therefore, sodium iodide symporter might be a putative target for endocrine disruptors. Objective of the research – investigation of sodium iodide symporter production after long-term exposure to endocrine disruptor dichlorodiphenyltrichloroethane (DDT) in different periods on postnatal development. Newly borne and 7-week old male Wistar rats were exposed to low doses of DDT during 6 and 10 weeks. Expression of sodium iodide symporter in thyroid cells was evaluated by immunohistochemistry. Quantification of sodium iodide symporter, thyroid hormones (T3 and T4) and thyroid stimulating hormone (TSH) in serum was performed by enzyme-linked immunosorbent assay. The investigation also included morphological examination of thyroid slides and morphometry. Adult rats after 6 weeks of exposure showed diminished level of total T4 and increase in T3 production, associated with significantly lowered TSH and sodium iodide symporter serum concentration. Rats, exposed to endocrine disruptor since birth, demonstrated slight decrease in T4 and sodium iodide symporter. Reduced level of free T3 and elevated serum TSH were found in adult rats after 10 weeks of exposure. Exceeded level of serum sodium iodide symporter was revealed. It was provided by increased number of thyroid cells, producing this protein, due to formation of numerous microfollicles in the thyroid gland. Young rats after 10 weeks of exposure demonstrated diminished total and free T3 levels and elevated TSH. No up-regulation of sodium iodide symporter expression was found. Morphological examination revealed enlarged follicles and no microfollicular rearrangement of thyroid parenchyma. Considered that low dose exposure to endocrine disruptor DDT irreversibly depresses expression of membrane glycoprotein sodium iodide symporter, which provides iodine uptake by the thyroid gland. After-birth exposure impairs compensatory activation of proliferation and increase in number of sodium iodide symporter-producing cells.