bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphokinetic parameters comparison between euploid and aneuploid blastocysts
Authors: Le Phuong Thi Bich , Le Anh Hoang , Nguyen Loc Minh Tai , Dang Vinh Quang 
Published: May 2021

Background: Pre-implantation genetic testing for aneuploidy (PGT-A) has been using for years in embryoselection. However, this is an invasive method and may cause harm to the embryos. Therefore, time-lapse monitoring has been thought to be an alternative approach for embryo selection due to its efficiency. Up to now, several studies were investigating the relationship between the morphokinetic parameters and the embryo ploidy. However, the results are not consistent. This study aims to evaluate the correlation between morphokinetic parameters and PGT-A results.
Methods: This retrospective cohort study was conducted at IVFMD Phu Nhuan, My Duc Phu Nhuan Hospital, between September 2018 and June 2019. Patients undergoing PGT-A due to advanced maternal age, repeated implantation failure or recurrent miscarriage and having embryo cultured under time-lapse monitoring were included. Patients with the re-thawing embryo for PGT-A were not eligible. The time from insemination to the pronuclear appearing (tPN), the onset of two to eight-cell divisions (t2 to t8) and the duration of the second cell cycle (cc2, t3-t2) were observed.
Results: There were 39 patients included in the study, with mean age of 36.4 +/- 5.7 years. A total of 110 blastocysts were biopsied. Amongst them, 63 embryos (57.3%) were euploidy (group 1), and 47 embryos (42.7%) were aneuploidy (group 2). There was no significant difference between euploid, and aneuploid embryos regarding all morphokinetic parameters, including tPN, t2, t3, t4, t5, cc2, and t8 (7.2 +/- 1.5 hours vs. 7.4 +/- 1.6 hours; 25.0 +/- 2.8 hours vs. 25.6 +/- 3.2 hours; 35.8 +/- 3.6 hours vs. 36.9 +/- 3.3 hours; 37.5 +/- 4.4 hours vs. 38.3 +/- 4.3 hours; 49.2 +/- 5.52 hours vs. 49.9 +/- 6.2 hours; 10.7 +/- 2.6 hours vs. 11.2 +/- 1.7 hours; and 55.7 +/- 6.4 hours vs. 58.1 +/- 7.4 hours, respectively).
Conclusion: In this study, we found no difference in the morphokinetic parameters between euploid and aneuploid embryos.
Staphylococcus aureus and S. epidermidis in biological systems of hospital environment: Antibiotic resistance patterns in regions of Ukraine
Authors: Berezhna A. V. , Tertyshnyi V. O. , Makarova V. I. , Chumachenko T. O. 
Published: June 2021

Staphylococcus bacteria are ubiquitous and often circulate in the biological systems of the hospital environment. Staphylococci have developed antibiotic resistance mechanisms resulting in a significant medical and economic burden to the healthcare system. The goal of our research was to conduct a comparative analysis of resistance to antibiotics in S. aureus and S. epidermidis isolates found in surgical hospitals in Kharkiv and Poltava regions. In 2013 through 2019, 151,015 and 98,754 tests were made by disc-diffusion method to identify the sensitivity in the S. aureus strains to antibiotics in Kharkiv and Poltava regions respectively. In 2013–2015, 15,589 tests were made in Kharkiv region to identify antibiotics sensitivity in S. epidermidis strains. Comparison of antibiotic resistance of the S. aureus strains in Kharkiv and Poltava regions was performed using the Pearson Chi-square test (χ2) and Fisher’s exact test. The proportion of S. aureus strains resistant to penicillins, cephalosporins, carbapenems, aminoglycosides, and macrolides was higher in Kharkiv region in terms of statistical validity than in Poltava region. Overall, the proportion of S. aureus strains resistant to lincozamids, tetracycline antibiotics, and fluoroquinolones in Poltava region was higher in terms of statistical validity than in Kharkiv region. An analysis of resistance of S. aureus strains to linezolid demonstrated that in Poltava region the proportion of resistant microorganisms was higher in terms of statistical validity in 2013–2014 and in 2016–2018. In Kharkiv region, in 2013 and in 2014, 96.3% and 89.1% of isolated strains of S. aureus respectively, were resistant to vancomycin. In 2019, more than a quarter of the located isolates (26.6%) in Poltava region were resistant to this antibiotic. The analysis of the dynamic of resistance in S. epidermidis isolates demonstrated that in 2015 nearly half of the isolates located in Kharkiv region were insensitive to penicillin antibiotics. Between 2013 and 2015, the spread of resistance to cephalosporins, aminoglycosides, macrolides, and fluoroquinolones among the S. epidermidis isolates noticeably increased. When S. epidermidis resistance to vancomycin was analyzed, a decrease in the proportion of resistant strains from 88.0% in 2013 to 8.7% in 2015 was noted. A promising direction for further research is the creation of passports of microorganism resistance in the regions and various health-care settings, as well as the creation of a unified national database network on microorganism resistance using modern methodologies for determining the phenotypes and genotypes of microorganisms.
Шенфельдская волость: история возникновения и исчезновения меннонитских поселений
Authors: Черказьянова Ирина Васильевна 
Published: June 2021

The author studies the history of the Shenfeld Mennonite volost foundation and destruction. The research tasks were as follows: to analyze the reasons of this volost establishing at the period of the colonist reform; to study development of the settlements at the second part of the 19th century, to find out how its inhabitants participated in the modernization processes; to follow the cultural and spiritual life of the colonies and Aleksandrovsky district as a whole; to highlight the problem of the Mennonite settlements destruction. The Shenfeld (Krasnopolskaya) volost was situated in the Aleksandrovsky district of the Ekaterinoslav province. It was founded in 1873. Its uniqueness lays in the fact that it did not have definite administrative-territorial boundaries, since the possessions were dispersed. The population was made up of the Mennonites from Molochansk and (partly) Khortytsa colonies. The families settled on farms, united into small villages. The process of the eastern part of Aleksandrovsky district settlement was a part of the German colonization in this area and in the province as a whole. However, the volost differed from the other ones because it only consisted of private farms. Its economy was organized on the purchased (not granted by the tsars) land. The author pays attention to Zilberfeld estate that is the least studied settlement of the volost. The fates of its owners have not been researched yet. The volost was famous for its prosperity and contributed greatly into this region economy development. The destruction of an entire volost during the Civil War, that was the result of the Makhnovist movement, is also one of the important parts of its tragic history.
Key words: Mennonites, Shenfeld (Krasnopolskaya) volost, Alexandrovsky district, Ekaterinoslav province, Zilberfeld estate, Civil war, Yantsen family, Nestor Makhno.
Effect of neural therapy on NGF and BDNF serum levels in patients with chronic pain. A pilot study
Authors: Garzón Carolina , Caminos Jorge Eduardo , Alzate Juan Pablo , Eslava-Schmalbach Javier Hernando , Garcés María Fernanda , Beltrán-Dussan Eduardo Humberto 
Published: June 2021

Introduction: Neurotrophins (NT) are a family of proteins consisting of the nerve growth factor (NGF), the brain-derived neurotrophic factor (BDNF) and NT-3 and NT-4/5. These proteins play an essential role in neuronal survival, differentiation, and proliferation.
Objectives: To analyze the variations of NGF and BDNF serum levels in patients with chronic pain after undergoing neural therapy and to establish the effects of this type of intervention on their quality of life.
Materials and methods: Prospective pilot study conducted in 10 patients with chronic pain treated with neural therapy between July 2017 and April 2018 in Bogotá D.C., Colombia. Three consultations were performed (one in which the intervention was initiated, and two follow-up visits every three weeks). During each consultation, the patients’ quality of life was assessed using the SF-12 scale and their NGF and BDNF serum levels were measured. Data were analyzed by means of descriptive statistics, using medians and interquartile ranges for quantitative variables, and absolute frequencies and percentages for qualitative variables.
Results: The median score on the SF-12 scale tended to improve in the first and second follow-up visits compared with the baseline score (pre-intervention), particularly during the first follow-up visit (consultation No. 1: 34.5; follow-up No. 1: 39.5, and follow-up No. 2: 38). Median NGF serum levels had a downward trend after the intervention, particularly in the first follow-up visit (157.6, 42.95, and 237.8, respectively), and in the case of BNDF, an overall downward trend was also found (29.96, 19.24 and 20.43, respectively). An improvement in quality of life related to the decrease in the serum levels of both neurotrophins was observed.
Conclusion: Neural therapy intervention reduced NGF and BDNF serum levels and improved the quality of life of the participants. Therefore, the behavior of these neurotrophins could become a biomarker for the diagnosis, treatment, and follow-up of patients with chronic pain.
Friends, physical activity, and sedentary behavior in university students: A social network analysis
Authors: Arango-Paternina Carlos Mario , Cardona-Gómez Jason , Arboleda-Serna Víctor Hugo , Muñoz-Rodríguez Diana Isabel 
Published: June 2021

Introduction: Understanding the processes of socialization during youth and their association with healthy behaviors is crucial for university education.
Objective: To explore the associations of the characteristics of friendship networks with being physically active and having a sedentary behavior in university students.
Materials and methods: Cross-sectional study conducted in 475 university students and based on a social network analysis. Measurements included sociodemographic, physical activity, sedentary behavior, and friendship network variables. The associations between the characteristics of friendship networks and physical activity and sedentary behavior were explored using logistic regression models. Confidence intervals (95%) were estimated and a significance level of p<0.05 was considered.
Results: In women, being part of at least a cluster of friends was significantly associated with being physically active (adjusted OR [aOR]: 2.3; 95%CI: 1.2-4.6), while being popular was significantly associated with a lower probability of being physically active (aOR: 0.3; 95%CI: 0.1-0.7). Also, a ten-percentage point increase in active friends was significantly associated with a higher probability of being physically active (aOR: 9.3; 95%CI: 3.5-24.6). Regarding sedentary behavior, a ten-percentage point increase in the number of sedentary friends was significantly associated with a higher probability of being sedentary (aOR: 5.5; 95%CI: 2.5-12.3). In men, none of the studied associations were statistically significant.
Conclusion: Some characteristics of social network are relevant for female university students in relation to their physical activity levels and sedentary behaviors. These findings highlight the need to consider friendship network dynamics for designing initiatives aimed at physical activity promotion and sedentary behavior reduction.
Mechanochemical technology of iron extraction from enrichment tailings
Authors: Golik V. I. , Dmitrak Yu. V. , Razorenov Yu. I. , Maslennikov S. A. , Lyashenko V. I. 
Published: June 2021

The article describes the results of studies on ore dressing waste processing at the enterprises of the Kursk Magnetic Anomaly with production of metals and building materials. About 1.8 billion tons of tailings were stored there. Significant feature of deposits formation is division of tailings by size and specific gravity in water stream, since tailings are transported from the enrichment plant to the tailing dams by hydrotransport. Characteristics of the tailings from wet magnetic research method was applied, including system analysis and scientific generalization, data processing using methods of statistics, probability theory and mathematical modeling. The authors have systematized the results of tailings leaching of following types: agitation leaching in percolator, agitation leaching after activation in disintegrator in the dry state and reagent leaching in disintegrator. Regression analysis of experimental data have been carried out, on the basis of which graphs of dependence of iron extraction on the values of variable process factors were constructed. The used enrichment technologies are limited by extraction limit, which results in processing tailings. The use of these tailings by traditional technologies is not economically efficient, and upgrading of enrichment processes is advisable using hydrometallurgical and chemical technologies. Promising direction in metals extraction from mining waste is combination of processing technologies based on possibilities of both chemical enrichment and activation in disintegrator. It was determined that mechanochemical activation of tailings in disintegrator simultaneously with leaching can significantly increase extraction while the processing time is reduced hundredfold. Recommended technology may be in demand at mining enterprises with the prospect of transition to underground mining.
Influence of ferrous metallurgy enterprises on atmospheric air quality as an ecological component of territories sustainable development. Report 1
Authors: Glushakova O. V. , Chernikova O. P. 
Published: June 2021

The main provisions of the Concept of Sustainable Development, formulated in 1992 at the conference in Rio de Janeiro, based on the economy – environment – society sustainability triad, are accepted as the basis for development by most countries. Over the past period, an institutional framework for sustainable development has been formed both at the international level and at the level of states. Reducing level of air pollution is one of the key tasks, solution of which is necessary to achieve the 2030 Sustainable Development Goals stated by the United Nations. Despite of adoption of the Concept of Transition to Sustainable Development in Russia back in 1996, focus on environmental component took a long time to be made. The article considers the stages of regulatory environment development aimed at ensuring sustainable development and reducing level of air pollution in Russia. It was revealed that a significant expansion of the regulatory and legal field in this area occurred only in 2017 – 2019. In many ways, this is due to Russia’s orientation towards achieving the 2030 Sustainable Development Goals stated by the UN, and adoption of the national development goals of the Russian Federation. It was found that despite the use of such financial mechanisms as the state program of the Russian Federation “Environmental Protection” and the national project “Ecology” to achieve sustainability goals, the share of environmental protection expenditures in total expenditures of the federal budget in 2019 was only 1.3 %. At present, in twelve cities of the Russian Federation, level of air pollution is assessed as high and very high. In seven of them, ferrous metallurgy enterprises operate, which exert significant anthropogenic pressure on the environment.
Deterministic Application of Process-centric Law to the System-centric Requirements of Procurement Procedures
Authors: Wickens David John 
Published: May 2021

South Africa's public procurement system is accorded constitutional status, establishing fundamental requirements for the operation of the system. The application of these constitutional system requirements and their interpretation in the judicial adjudication of procurement cases have highlighted the tension between the administrative, or process-centric, legal requirements and the system-centric nature of procurement procedures. The importance of a deterministic approach for procurement decision-making can be considered from two angles – the certainty of the procurer in the conformity of its own conduct and external certainty to diminish the risk of unnecessary challenge.
This article revisits the foundational rationale for system-based procurement procedures and associated decision-making for its potential for finding a deterministic approach to balancing the legal requirements, both system- and process-based. These principles are tested against a selection of adjudicated outcomes to formulate practical recommendations for practitioners aimed at deterministic decision-making in the procurement process.
What's new for the clinician? - Excerpts from and summaries of recently published papers
Authors: Yengopal Veerasamy 
Published: May 2021

1. Is there an association between stress and periodontitis? JM Coelho, SS Miranda, SS da Cruz, et al. Is there association between stress and periodontitis? Clinical Oral Investigations. 2020; 24: 2285-94.
2. Is there an association between periodontitis and all-cause and cancer mortality? P Chung, T Chan. Association between periodontitis and all-cause and cancer mortality: retrospective elderly community cohort study. BMC Oral Health. 2020; 20: 168.
Oral health care for patients undergoing therapy for head and neck cancer in KwaZulu-Natal, South Africa - A qualitative study
Authors: Bauluck-Nujoo Bibi S , Singh Shenuka 
Published: May 2021

BACKGROUND: There is limited published evidence in KwaZulu-Natal on access to oral health care for patients undergoing cancer therapy in the head and neck region. OBJECTIVES: This study aimed to assess patients' oral health-related perceptions, practices and needs during cancer therapy. METHODS: This was a descriptive case study. A semi-structured face-to-face interview was conducted with volunteers (n=12) undergoing cancer therapy in head and neck region. Purposive sampling was used to select study participants who were recruited from a public tertiary central referral hospital in KwaZulu-Natal. A semi-structured interview was also conducted with the eThekwini district coordinator for oral health services to gain better insight into oral health service delivery for patients with special needs. RESULTS: The results indicated that oral health care in the sample population was not prioritised. Some of the emergent themes included: participants' knowledge and oral health self-care practices, support for participants to cope with head and neck cancer, barriers in accessing facility-based oral health care (poor access to dental services, failure of the local clinic to provide appropriate care), lack of referral by oncology care practitioners for patients to access dental care, and existing gaps in oral health service delivery The reported non-existence of a specific oral health policy to address cancer and the absence of a risk factor intervention program highlighted some of the shortcomings for quality oral health service delivery in this population group. CONCLUSION: The results indicated that oral health care is important for patients undergoing cancer therapy. There is an urgent need for oral health planning in the province to take into account the specific oral health needs of this vulnerable population.
During the COVID-19 pandemic, oral health services including routine treatment may continue but must follow established international and South African protocol
Authors: Makhubele KC 
Published: May 2021

The South African Dental Association (SADA) hereby responds to the statement released by the World Health Organization (WHO): Considerations for the provision of essential oral health services in the context of COVID-19, on 7th August 2020.
After careful consideration and in consultation with workstreams working in various protocols regarding the provision of oral health services during the COVID-19 pandemic, SADA respectfully yet strongly disagrees with the World Health Organization's (WHO) recommendation to delay "routine" dental care in certain situations due to COVID-19.
A blanket statement such as the recent one by the WHO cannot, therefore, be supported. It is without a doubt that oral health is integral to overall health and neglect and delay of certain treatments may lead to extensive damage and increased financial implications to correct.
Consequently, dentistry is essential healthcare, because of its role in evaluating, diagnosing, preventing or treating oral diseases, which can adversely affect systemic health. Each country is at a different stage of the pandemic and each country has to respond appropriately based on its assessment of its unique situation.
Experiências dos programas de alimentação escolar: um estudo bibliométrico
Authors: Silva Romário Nunes da , Bezerra Amanda Souza , Soares Beatriz Oliveira , Severo Jessica Porfirio , Andrade Horasa Maria Lima da Silva , Andrade Luciano Pires de 
Published: June 2021

RESUMO: Os programas de alimentação escolar despontam como um dos instrumentos capazes de melhorar a nutrição e segurança alimentar dos estudantes. Além disso, programas como PNAE (Programa Nacional de Alimentação Escolar) tem fortalecido a agricultura familiar ao preferir a aquisição de seus produtos. Nesse sentido, o presente estudo teve por objetivo traçar um panorama de publicações que trazem experiências dos impactos de programas de alimentação escolar à nutrição e segurança alimentar dos estudantes e os ganhos socioeconômicos dos agricultores familiares. Como instrumento metodológico utilizou-se a bibliometria. A coleta dos dados aconteceu em julho de 2020 e abrangeu a produção de artigos científicos entre os anos de 2005 e 2019. Como fonte de dados, realizou-se uma varredura nas bases de dados acadêmicas da Scielo, Scopus e Web of Science. Para a busca dos artigos, utilizou-se uma combinação dos termos “Programa nacional de alimentação escolar”; “Merenda escolar e segurança alimentar e nutricional”; “Agricultura familiar e adesão à alimentação escolar”. Tais termos também foram aplicados no idioma inglês. Considerou-se apenas artigos científicos de cunho teórico-empírico. Após uma triagem que excluiu os artigos repetidos e os que não atendiam ao tema, restou-se 46 artigos, os quais foram analisados no presente estudo bibliométrico. Verificou-se uma concentração de publicações em um grupo de periódicos, o que contempla os preceitos da Lei de Bradford. Quanto a produtividade por autor, a Lei de Lotka não foi amplamente atendida, pois, verificou-se uma pulverização da produção e do total de 160 autores encontrados com a pesquisa, somente 19 autores possuem mais de uma publicação sobre o tema. As palavras de maior recorrência foram Agricultura Familiar, PNAE e Alimentação Escolar. Em relação aos procedimentos metodológicos, constatou-se que a abordagem qualitativa foi a mais utilizada. O tema políticas de alimentação escolar tem relevância científica, assim, a realização de avaliação sobre os níveis dessas produções é válido.
Palavras-chave: Agricultura familiar; Bibliometria; PNAE.