bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cross-sectional study of demonstrating expertise and job satisfaction in pharmacists and dietitians working in community pharmacies in Japan
Authors: Shoji Masaki , Sakane Naoki , Ito Naoki , Sunayama Keiji , Onda Mitsuko 
Published: November 2021

Abstract
Background
In Japan, there has been a private-sector initiative to register dietitians in pharmacies. There is not yet an adequate amount of data on the attitudes of dietitians in pharmacies regarding their work.
Objectives
To assess the attitudes of pharmacists and dietitians working in community pharmacies in Japan about their work, and particularly about demonstrating expertise and overall job satisfaction.
Methods
We administered a web-based questionnaire to pharmacists and dietitians working in pharmacy branches with registered dietitians at two pharmacy chains that agreed to cooperate. We used our own 7-item questionnaire and compared the scores for each item between pharmacists and dietitians.
Results
A total of 61 persons (22 pharmacists and 39 dietitians) answered the questionnaire. The item with the highest mean score (standard deviation) for pharmacists was "I feel that I am helpful to patients," at 3.50 (0.74), and for dietitians it was "I have colleagues at my workplace whom I can talk to when I have a problem," at 3.51 (1.00). Conversely, the items with the lowest mean score (standard deviation) were "I am satisfied with my current job" for pharmacists, at 3.14 (0.83), and "I can grow sufficiently as a professional" for dietitians, at 2.41 (0.97). As a result of factor analysis, the seven-item question could be divided into two factors: "demonstrating expertise" and "overall job satisfaction.” The factor-score for "demonstrating expertise" was significantly lower for dietitians than for pharmacists (p<0.01), but there was no significant difference in overall job satisfaction between the two professions (p=0.36). Further research is needed to understand why dietitians find “demonstrating expertise” difficult in pharmacies.
Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors
Authors: Kanno Akitake , Nakasato Nobukazu , Oogane Mikihiko , Fujiwara Kosuke , Nakano Takafumi , Arimoto Tadashi , Matsuzaki Hitoshi , Ando Yasuo 
Published: November 2021

Abstract
Non-invasive human brain functional imaging with millisecond resolution can be achieved only with magnetoencephalography (MEG) and electroencephalography (EEG). MEG has better spatial resolution than EEG because signal distortion due to inhomogeneous head conductivity is negligible in MEG but serious in EEG. However, this advantage has been practically limited by the necessary setback distances between the sensors and scalp, because the Dewar vessel containing liquid helium for superconducting sensors requires a thick vacuum wall. Latest developments of high critical temperature (high-Tc) superconducting or optically pumped magnetometers have not allowed scalp-attached MEG due to cold or hot temperatures at the sensing point, respectively. Here we applied tunnel magneto-resistive (TMR) sensors that operate at room temperature. Improvement of TMR sensitivity with magnetic flux concentrators enabled scalp-attached and scalp-tangential MEG to target the largest signal component produced by the neural current below. In a healthy subject, our single-channel TMR-MEG system clearly demonstrated the N20m, the initial cortical component of the somatosensory evoked response after median nerve stimulation. Multisite measurement confirmed a spatially and temporally steep peak of N20m, immediately above the source at a latency around 20 ms, indicating a new approach to non-invasive functional brain imaging with millimeter and millisecond resolutions.
Multipoint Monitoring of Amplitude, Frequency, And Phase of Vibrations Using Concatenated Modal Interferometers
Authors: Chatterjee Kalipada , Arumuru Venugopal , Patil Dhananjay , Jha Rajan 
Published: November 2021

Abstract
Concatenated modal interferometers-based multipoint sensing system for detection of amplitude, frequency, and phase of mechanical vibrations is proposed and demonstrated. The sensor probes are fabricated using identical photonic crystal fiber (PCF) sections and integrated along a single fiber channel to act as a compact and efficient sensing system. Each identical probe acts as a modal interferometer to generate a stable interference spectrum over the source spectrum. In presence of external dynamic field about each probe, the probes respond independently, producing a resultant signal that is a superposition of each interferometer response signal. By analysing the resultant signals using computational techniques, the vibration parameters applied to each interferometer are realized. The sensing system has an operation range of 1 Hz-1 kHz with a sensitivity of 51.5 pm/V. Such a sensing system would find wide applications at industrial, infrastructural, and medical fronts for monitoring various unsteady physical phenomena.
Perovskite superlattices with efficient carrier dynamics
Authors: Xu Sheng , Lei Yusheng , Li Yuheng , Lu Chengchangfeng , Yan Qizhang , Gong Huaxin , Zhang Song , Zhou Jiayun , Zhang Ruiqi , Chen Yimu , Tsai Hsinhan , Gu Yue , Hu Hongjie , Lo Yu-Hwa , Nie Wanyi , Lee Taeyoon , Luo Jian , Yang Kesong , Jang Kyung-In 
Published: November 2021

Abstract
Compared with their three-dimensional counterparts, low-dimensional metal halide perovskites with periodic inorganic/organic structures have shown promising stability and hysteresis-free electrical performance, which paves the way for next-generation optoelectronic devices. However, when integrated in devices, they have relatively limited efficiencies because devices usually require carrier transport through the film thickness direction. In conventionally grown single crystals, the carrier transport in the thickness direction is hindered by the insulating organic spacers. In addition, the strong quantum confinement from the organic spacers limits the generation and transport of free carriers. The carrier dynamics is further compromised by the presence of grain boundaries in polycrystals. Here, we report a low-dimensional metal halide perovskite superlattice with efficient carrier transport in three dimensions by epitaxial growth. Epitaxy on a slightly lattice-mismatched substrate compresses the organic spacers in the superlattice, which weakens the quantum confinement and further improves carrier dynamics. The performance of a low-dimensional perovskite superlattice solar cell has been certified under the quasi-steady state for the first time. Moreover, the device shows an unusually high open-circuit voltage, due to a unique intra-band exciton relaxation mechanism.
Three-dimensional changes in the upper airway and craniomaxillofacial morphology of patients with Angle Class III malocclusion treated with a Frankel III appliance
Authors: Liu Yinan , Yang Kai 
Published: November 2021

Abstract
Background
Angle Class III malocclusion, characterized by a concave profile, can cause serious harm to children’s physical and mental health. The Frankel III appliance is an effective treatment for Angle Class III malocclusion in mixed denition. We explored three-dimensional changes in the upper airway and craniomaxillofacial morphology, after one year of Frankel III appliance treatment, in children with Angle Class III malocclusion.
Methods
We included 20 children (9 males), aged 8-10 years, with Angle Class III malocclusion from the Orthodontics Department of our hospital. Each child was treated with a Frankel III appliance for one year. Cone beam computed tomography was performed before and after treatment to evaluate three-dimensional changes in the upper airway and craniomaxillofacial morphology.
Results
After one year of treatment, in the upper airway, we observed significant increases in the nasopharynx volume and height (P<0.05); the velopharyngeal volume, height, and average cross-sectional area (P<0.05); the glossopharynx volume and minimum cross-sectional area (P<0.05); and the laryngopharynx height (P<0.05). Accordingly, the total upper airway volume, height, and average cross sectional area increased significantly (P<0.05). An examination of craniomaxillofacial morphology showed significant increases in some bone tissues (P<0.05) and dental measurements, and a significant reduction in the inclination of the mandibular central incisor (P<0.05).
Conclusion
Children with Angle class III malocclusion treated with a Frankel III appliance showed no upper airway narrowing, even after repositioning the mandible posteriorly. Moreover, treatment promoted forward maxilla development and increased its width, in both the dental arch and alveolar bone, which provided a more harmonious craniofacial morphology.
Spatial Distribution and Risk Assessment of Heavy Metals in Urban Road Dust From Shenyang, a Heavy Industrial City in Northeast China
Authors: Cui Zhengwu , Wang Yang , Yu Rui , Yu Yong , Luo Nana 
Published: November 2021

Abstract
124 road dust samples were collected from an urban area of Shenyang, a typical heavily industrial city in Northeast China, to study the concentration, pollution level, source, spatial distribution, and health risk of heavy metals. The average concentrations of Cd, Cr, Cu, Mn, Ni, Pb, and Zn were 1.802, 132.1, 60.33, 778.3, 54.80, 86.73, and 391.2 mg/kg, respectively. The levels of metal pollution ranged from minimal to extremely high, with average levels in the ranked order: Mn < Ni < Cr < Cu < Pb < Zn < Cd, indicating that the road dust was heavily polluted by Cd, Zn, and Pb. Source identification results demonstrated that Cr, Mn, and Ni had mixed sources including industrial emissions and weathering of soil, pavements, and building materials, while Cu, Pb, and Zn mainly originated from traffic and industrial activities, and Cd had a complex mixture of sources (with various anthropogenic sources). Hotspots of heavy metal pollution levels were closely correlated with local anthropogenic activities, such as industrial discharge, traffic-related exhaust emissions, and agricultural activities. Furthermore, health risk assessment revealed significant non-carcinogenic risks for children from multiple metals, and the carcinogenic risk assessment identified significant risks for children from Cd, with ingestion being the main exposure pathway for carcinogenic and non-carcinogenic risk for adults and children. However, no health risk was observed due to dermal and inhalation exposure pathways.
Overexpressed Integrin Alpha 2 Inhibits the Activation of the Transforming Growth Factor β Pathway in Pancreatic Cancer via the TFCP2-SMAD2 Axis
Authors: Cai Hongkun , Guo Feng , Wen Shuang , Jin Xin , Wu Heshui , Ren Dianyun 
Published: November 2021

Abstract
BackgroundIntegrin alpha 2 (ITGA2) has been recently reported to be an oncogene and to play crucial roles in tumor cell proliferation, invasion, metastasis, and angiogenesis. Our previous study showed that ITGA2 was overexpressed in pancreatic cancer and promoted its progression. However, the mechanism of ITGA2 overexpression and other mechanisms for promoting the progression of pancreatic cancer are still unclear. MethodsThe GEPIA database was used to confirm the expression of ITGA2 in pancreatic cancer. To verify the influence of ITGA2 and TGF-β on the morphological changes of pancreatic cancer and tumor cell progression, we conduct CCK8 test, plate cloning, flow cytometry experiments and animal experiments. Then we conduct Western blot, RT-qPCR to explore the relationship between ITGA2 and TGF-β, and then find the key molecules which can regulate them by immunoprecipitation, Western blot, RT-qPCR, CHIP, nuclear and cytoplasmic separation test.ResultsThe results of the present study show that the abnormal activation of KRAS induced the overexpression of ITGA2 in pancreatic cancer. Moreover, ITGA2 expression significantly suppressed the activation of the TGF-β pathway. ITGA2 silencing enhanced the anti-pancreatic cancer proliferation and tumor growth effects of TGF-β. Mechanistically, ITGA2 expression suppressed the activation of the TGF-β pathway by inhibiting the SMAD2 expression transcriptionally. In addition, it interacted with and inhibited the nuclear translocation of TFCP2, which induced the SMAD2 expression as a transcription factor. Furthermore, TFCP2 also induced ITGA2 expression as a transcription factor, and the TFCP2 feedback regulated the ITGA2-TFCP2-SMAD2 pathway. ConclusionTaken together, our results indicate that ITGA2 expression inhibited the activation of the TGF-β pathway in pancreatic cancer via the TFCP2-SMAD2 axis. Therefore, especially when combined with TGF-β treatment, ITGA2 might be a potential clinical therapeutic target for pancreatic cancer.
Alterations of Chromatin Accessibility of Human Mesenchymal Stem Cells During Early Differentiation Stage Toward Osteoblasts and Adipocyte
Authors: Liu Jianyun , Gan Lijun , Ma Baichen , He Shan , Wu Ping , Li Huiming , Xiong Jianjun 
Published: November 2021

Abstract
Although differential expression of genes is apparent during the adipogenic/osteogenic differentiation of marrow mesenchymal stem cells (MSCs), it is not known whether this is associated with changes in chromosomal structure. In this study, we used ATAC-sequencing technology to observe variations in chromatin assembly during the early stages of MSC differentiation. This showed significant changes in the number and distribution of chromosome accessibility at different time points of adipogenic/osteogenic differentiation. Sequencing of differential peaks indicated alterations in transcription factor motifs involved in MSC differentiation. Gene Ontology (GO) and pathway analysis indicated that changes in biological function resulted from the alterations in chromatin accessibility. We then integrated ATAC-seq and RNA-seq and found that only a small proportion of the overlapped genes were screened out from ATAC-seq and RNA-seq overlapping. Through GO and pathway analysis of these overlapped genes, we not only observed some known biological functions related to adipogenic/osteogenic differentiation but also noticed some unusual biological clustering during MSC differentiation. In summary, our work not only presents the landscape of chromatin accessibility of MSC during differentiation but also helps to further our understanding of the underlying mechanisms of gene expression in these processes.
Development of a Family-Community Interactive Program to Prevent Postpartum Depression: A Mixed Method Study Protocol
Authors: Zhao Di , Niu Meilan , Ma Rui , Yang Huashan , Guo Panpan , Wu Chuqiao , Wang Yan , Wang Shanshan , Wang Peng 
Published: November 2021

Abstract
Background: Postpartum depression has become a serious public health hazard. Family and community support can be effective in alleviating the symptoms of postpartum depression. Currently, there is a lack of research directed at promoting family and community caregiver interactions to avoid postpartum depression. Therefore, this study aimed to construct a family-community interaction program to avoid postpartum depression.Method: This mixed-methods study with the longitudinal design consists of two phases. Phase one :quantitative study. A quantitative analysis method is applied to conduct longitudinal research on the pregnant and parturient women to explore the status quo of indicators of family support, social support, quality of life, and postnatal depression. Phase two: qualitative study to explore the current status of the interaction. In this phase, the subjects will be selected through purposive sampling; In-depth individual interviewing will be used for data collection. Mixed data were used to analyze qualitative and quantitative results and to construct a family-community interaction intervention program.Discussion: The present research is the first study to investigate family-community Interactions. For the purposes of the study, a mixed-methods approach will be used which aims to develop family-community Interactive Program, which can prevent postpartum depression of pregnant and parturient women and clarify the responsibilities of family members and Community caregivers in the prevention of postpartum depression, cultivating the awareness of interaction and collaboration between families and communities, and providing the targeted intervention policy to long-term positive interaction.Trial registration number: ChiCTR2100045901
Chemical Composition and Antioxidant Activity of the Ceratonia Siliqua L. Seeds Oil
Authors: Abbout Said , CHEBABE Driss , REHIOUI Malak , ERRAMLI Hamid , HAJJAJI Najat 
Published: November 2021

Abstract
In this work, we are interested in the antioxidant activity of Ceratonia Siliqua L. seeds oil. After extraction of seeds oil by Soxhlet, we characterized by GC-MS and evaluated the antioxidant activity by DPPH• and ABTS+•. The obtained results show that the seeds oil of Ceratonia Siliqua L. contains various organic compounds, the majority of which are fatty acids. Furthermore, the determination of IC50 by the DPPH• and ABTS+• methods show that cyclohexane has good IC50 compared to hexane.
Identification of Metastasis-Associated Gene And Its Correlation With Immune Infiltrates For Skin Cutaneous Melanoma
Authors: Luan Hong , He Ye , Jian Linge , Zhang Tuo , Zhou Liping 
Published: November 2021

Abstract
Background: Skin cutaneous melanoma is a malignant and highly metastatic skin tumor. As the most common cause of death in skin cancer, its morbidity and mortality are still rising worldwide. However, the molecular mechanisms of melanoma metastasis are unclear. Methods: Three Gene Expression Omnibus (GEO) datasets (GSE15605, GSE7553 and GSE8401) were downloaded to identify the differentially expressed genes (DEGs) between primary and metastatic melanoma samples. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were performed to explore the functional of DEGs by Metascape. The protein-protein interaction (PPI) network was constructed using STRING tool and Cytoscape software. We used the cytoHubba plugin of Cytoscape to identify the most significant hub genes by four topological analyses (Degree, MCC, DMNC, and MNC). Hub genes expression was validated using UALCAN website. Finally, we explored the association between metastasis-associated genes and immune infiltrates through Tumor Immune Estimation Resource (TIMER) database.Results: In total, we obtained 196 DEGs including 12 upregulated and 184 downregulated genes. GO and KEGG enrichment results indicated that DEGs were mainly concentrated in epidermis development, cornified envelope, structural molecule activity, and p53 signaling pathway. Eight hub genes were identified to be closely related to melanoma metastasis, including SPRR1B, DSC1, PKP1, TGM1, DSG1, IVL, SPRR1A and DSC3. On the ULCAN website, all hub genes expression levels are lower in metastatic tissues than in primary cancers. Results from TIMER database revealed that DSC1 and TGM1 were significantly related with most of immune cell infiltration.Conclusions: SPRR1B, DSC1, PKP1, TGM1, DSG1, IVL, SPRR1A and DSC3 may be hub genes involved in the progression of melanoma metastasis and thus may be regarded as therapeutic targets in the future. DSC1 and TGM1 play an important role in the microenvironment of metastatic melanoma by regulating the tumor infiltration of immune cells.
A Pyroptosis-Related LncRNA Signature for Predicting Prognosis and Treatment in Hepatocellular Carcinoma
Authors: Zhang Yuhao , Zhang Jiaxin , Wei Fengxian , Zhang Haodong , Wang Dongdong , Deng Hongyang , Xu Xiaodong 
Published: November 2021

Abstract
Background: Hepatocellular carcinoma (HCC), which carries a very bad prognosis, is a common malignant tumor worldwide. This study aim to identify a pyroptosis-related long non-coding RNA(pyLncRNA) prognostic signature in HCC by integrated bioinformatics analysis. Methods: All expression profiles of HCC were obtained from The Cancer Genome Atlas (TCGA) and pyroptosis-related genes were from the GSEA website. After identified differentially expressed pyLncRNAs, univariate Cox regression and Lasso analysis were used to identify a pyroptosis-related LncRNAs prognositic signature(py-LPS). Internal validation was used to validate the prognostic value of the py-LPS via the Kaplan-Meier(K-M) curve and receiver operating characteristic(ROC) curve. Additional, we established the nomogram and analyzed the correlation between the signature and immune immune infiltration as well as clinical treatment. Result: 7 pyLncRNAs were established the signature for HCC prognosis. K-M curves exhibited the low risk group presented a markedly longer OS than the high. Clinical subgroups analysis based age, gender, grade and stage yielded the similar results. The signature had an independent prognostic value for HCC(p<0.001). Nomogram estimated one-, three- and five-year survival were 0.777, 0.741 and 0.709. Then, gene set enrichment analysis(GSEA) demostrated significant pathways. Futhermore, we found immune cell infiltration and immunotherapy targets was associated with the signature,which could provided clinical recommendations for chemotherapy.Conclusion: In this study, a novel pyroptosis-related LncRNAs porgnostic signature of HCC, correlated with immune infiltration, could predict the survival of HCC patients and give suggestions for clinical treatment.
Serum Total Bilirubin and Long-Term Prognosis of Patients With New-Onset Non-ST Elevation Myocardial Infarction: A Cohort Study
Authors: Yang Yi , Wang Jun , Ding A Ji Gu Li Wai Si , Xu Yanan , Jiang Haibing , Ma Kezhong , Zhu Tongjian 
Published: November 2021

Abstract
Background: The potential prognostic role of total bilirubin (TBIL) in patients with new-onset non-ST elevation myocardial infarction (NSTEMI) is not fully understood. This study aims to evaluate the potential predictive value of TBIL for long-term prognosis in patients with new-onset NSTEMI.Methods: Patients with new-onset NSTEMI that underwent emergency coronary angiography in our department from June 2015 to March 2020 were included. Baseline TBIL was measured at admission. SYNTAX scores were used to indicate the severity of coronary lesions. The association between TBIL and SYNTAX scores was analyzed using multivariate logistic regression. The patients were followed for the incidence of major adverse cardiac and cerebrovascular events (MACCEs). The association between TBIL and MACCEs was analyzed using Kaplan–Meier survival methods.Results: In total 327 patients were included in this study. Patients were divided according to tertiles of TBIL (first tertile <10.23 µmol/L, n = 109; second tertile 10.23–14.30 µmol/L, n = 109; and third tertile ≥14.30 µmol/L, n = 109). TBIL was independently associated with the severity of coronary lesions in patients with NSTEMI, with an adjusted odds ratio (OR) and 95% confidence interval (CI) for the third tertile and the second tertile compared with the first tertile of TBIL of 2.259 (1.197-4.263) and 2.167 (1.157-4.059), respectively (both p<0.05). After a mean follow-up of 30.33 months, MACCE had occurred in 57 patients. TBIL was independently associated with the increased risk of MACCEs, with an adjusted hazard ratio (HR) and 95% CI for the third tertile and the second tertile compared with the first tertile of TBIL of 2.737 (1.161 -6.450) and 3.272 (1.408-7.607), respectively (both p<0.05).Conclusions: Higher myocardial infarction admission TBIL might independently predict poor prognosis in patients with NSTEMI.