bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammals fail to regenerate organs when wound contraction drives scar formation
Authors: Yannas Ioannis V. , Tzeranis Dimitrios S. 
Published: July 2021

AbstractTo understand why mammals generally do not regenerate injured organs, we considered the exceptional case of spontaneous skin regeneration in the early lamb fetus. Whereas during the early fetal stage skin wounds heal by regeneration, in the late fetal stage, and after birth, skin wounds close instead by scar formation. We review independent evidence that this switch in wound healing response coincides with the onset of wound contraction, which is also enabled during late fetal gestation. The crucial role of wound contraction in determining the wound healing outcome in adults has been demonstrated in three mammalian models of severe injury (excised guinea pig skin, transected rat sciatic nerve, excised rabbit conjunctival stroma) where grafting the injury with DRT, a contraction-blocking scaffold of highly-specific structure, altered significantly the wound healing outcome. While spontaneous healing resulted in scar formation in these animal models, DRT grafting significantly reduced the extent of wound contraction, prevented scar synthesis, and resulted in partial regeneration. These findings, as well as independent data from species that heal spontaneously via regeneration, point to a striking hypothesis: The process of regeneration lies dormant in mammals until appropriately activated by injury. In spontaneous wound healing of the late fetus and in adult mammals, wound contraction impedes such endogenous regeneration mechanisms. However, engineered treatments, such as DRT, that block wound contraction can cancel its effects and favor wound healing by regeneration instead of scar formation.
A critical review of point-of-use drinking water treatment in the United States
Authors: Wu Jishan , Cao Miao , Tong Draco , Finkelstein Zach , Hoek Eric M. V. 
Published: July 2021

AbstractEnsuring safe water supply for communities across the United States is a growing challenge due to aging infrastructure, impaired source water, strained community finances, etc. In 2019, about 6% of public water utilities in the U.S. had a health-based violation. Due to the high risk of exposure to various contaminants in drinking water, point-of-use (POU) drinking water treatment is rapidly growing in popularity in the U.S. and beyond. POU treatment technologies include various combinations of string-wound sediment filters, activated carbon, modified carbon, ion exchange and redox media filters, reverse osmosis membranes, and ultraviolet lamps depending on the contaminants of concern. While the technologies are well-proven, highly commoditized, and cost-effective, most systems offer little in the way of real-time performance monitoring or interactive technology like other smart home appliances (e.g., thermostats, smoke detectors, doorbells, etc.). Herein, we review water quality regulations and violations in the U.S. as well as state-of-the-art POU technologies and systems with an emphasis on their effectiveness at removing the contaminants most frequently reported in notices of violations. We conclude by briefly reviewing emerging smart water technologies and the needs for advances in the state-of-the-art technologies. The smartness of commercially available POU water filters is critiqued and a definition of smart water filter is proposed.
A bibliometric study on biomimetic and bioinspired membranes for water filtration
Authors: Goel Gaurav , Hélix-Nielsen Claus , Upadhyaya Hari M. , Goel Saurav 
Published: July 2021

AbstractInsights into the biological channels and synthetic pore-forming assemblies have elucidated many fundamental aspects of selective water and solute transport over the last few decades. This has led to the development of novel technologies with unique selectivity and permeability. In terms of membrane separation technology, this development has proceeded by adapting either of two approaches: (i) one where biological channel proteins are reconstituted in suitable materials mimicking the biological bilayer membrane and (ii) one where selective transport is mimicked in synthetic structures. The development of water filtration membranes in the former approach takes advantage of aquaporin proteins as representative building blocks and that of carbon nanotubes and molecular pore-forming assemblies in the latter approach. The first approach is often referred to as the field dominated bybiomimetic membranesand the latter referred to asartificial water channels. In this study, a bibliometric analysis was conducted to investigate trends in these two areas based on growing publication trends, peer-reviewed journal selection, countries, institutions, authors, and collaborative networks. A total of 3199 records available from Scopus between 1962 and 2021 were extracted and analyzed. The results showed strong international collaborations and highlighted leading researchers and hubs of excellence in these two areas. This is very timely considering that the UN climate change conference (COP26) in Glasgow, UK later this year will bring focus to the global need for water treatment technologies. This work can serve as a quick reference for early-career researchers and industries working in the area of membrane development for water purification/filtration.
PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
Authors: Lundström Elin , Andersson Jonathan , Engström Mathias , Lubberink Mark , Strand Robin , Ahlström Håkan , Kullberg Joel 
Published: July 2021

AbstractThis study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (VA) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and VA were quantified with dynamic [15O]water-PET, and FF, with water-fat MRI. MRglu was assessed with dynamic [18F]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBATHI, by MRglu > 11 μmol/100 cm3/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MRglu (ρ ≤ − 0.87). After 3 h of cold, sBAT-FF decreased (− 2.13 percentage points) but tended to normalize during reheating although sBATHI-FF remained low. sBAT-perfusion and sBAT-VA increased during cold exposure (perfusion: + 5.2 ml/100 cm3/min, VA: + 4.0 ml/100 cm3). sBAT-perfusion remained elevated and sBAT-VA normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MRglu. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and VA, on the changes in FF observed during cold exposure, could not be ruled out.
New evidence of a Roman road in the Venice Lagoon (Italy) based on high resolution seafloor reconstruction
Authors: Madricardo Fantina , Bassani Maddalena , D’Acunto Giuseppe , Calandriello Antonio , Foglini Federica 
Published: July 2021

AbstractThis study provides new evidence of the presence of an ancient Roman road in correspondence to a paleobeach ridge now submerged in the Venice Lagoon (Italy). New high resolution underwater seafloor data shed new light on the significance of the Roman remains in the lagoon. The interpretation of the data through archive and geo-archaeological research allowed a three-dimensional architectural reconstruction of the Roman road. The presence of the ancient Roman road confirms the hypothesis of a stable system of Roman settlements in the Venice Lagoon. The study highlights the significance of this road in the broader context of the Roman transport system, demonstrating once more the Roman ability to adapt and to handle complex dynamic environments that were often radically different from today.
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study
Authors: Bal Antonin , Brengel-Pesce Karen , Gaymard Alexandre , Quéromès Grégory , Guibert Nicolas , Frobert Emilie , Bouscambert Maude , Trabaud Mary-Anne , Allantaz-Frager Florence , Oriol Guy , Cheynet Valérie , d’Aubarede Constance , Massardier-Pilonchery Amélie , Buisson Marlyse , Lupo Julien , Pozzetto Bruno , Poignard Pascal , Lina Bruno , Fassier Jean-Baptiste , Morfin Florence , Trouillet-Assant Sophie ,   COVID-SER Study group, Adnot Jerôme , Alfaiate Dulce , Bergeret Alain , Boibieux André , Bonnet Florent , Brunel-Dalmas Florence , Caire Eurydice , Charbotel Barbara , Chiarello Pierre , Cotte Laurent , d’Aubarede Constance , Durupt François , Escuret Vanessa , Fascia Pascal , Fontaine Juliette , Gaillot-Durand Lucie , Gillet Myriam , Godinot Matthieu , Gueyffier François , Josset Laurence , Lahousse Matthieu , Lozano Hélène , Makhloufi Djamila , Milon Marie-Paule , Moll Frédéric , Narbey David , Nazare Julie-Anne , Oria Fatima , Perry Marielle , Pitiot Virginie , Prudent Mélanie , Rabilloud Muriel , Samperiz Audrey , Schlienger Isabelle , Simon Chantal , Valette Martine 
Published: July 2021

AbstractA comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p = 0.07). The proportion of HCWs with a viral load > 5.0 log10 cp/mL (Ct value < 25) was less than 15% at 8 days after symptom onset; 12% of HCWs were positive after 40 days (Ct > 37). More than 90% of cultivable virus had a viral load > 4.5 log10 cp/mL (Ct < 26) and were collected within 10 days after symptom onset. Among negative HCWs, 6/190 (3.2%) seroconverted. Our data suggest that the determination of viral load can be used for appreciating the infectiousness of infected HCWs. These data could be helpful for facilitating their return to work.
Ecological effects on female bill colour explain plastic sexual dichromatism in a mutually-ornamented bird
Authors: Freitas Rita , Marques Cristiana , Cardoso Gonçalo C. , Trigo Sandra 
Published: July 2021

AbstractSex differences in ornamentation are common and, in species with conventional sex roles, are generally thought of as stable, due to stronger sexual selection on males. Yet, especially in gregarious species, ornaments can also have non-sexual social functions, raising the possibility that observed sex differences in ornamentation are plastic. For example, females may invest in costly ornamentation more plastically, to protect body and reproductive ability in more adverse ecological conditions. We tested this hypothesis with experimental work on the mutually-ornamented common waxbill (Estrilda astrild), supplementing their diets either with pigmentary (lutein, a carotenoid) or non-pigmentary (vitamin E) antioxidants, or alleviating winter cold temperature. We found that both lutein and vitamin E supplementation increased red bill colour saturation in females, reaching the same mean saturation as males, which supports the hypothesis that female bill colour is more sensitive to environmental or physiological conditions. The effect of vitamin E, a non-pigment antioxidant, suggests that carotenoids were released from their antioxidant functions. Alleviating winter cold did not increase bill colour saturation in either sex, but increased the stability of female bill colour over time, suggesting that female investment in bill colour is sensitive to cold-mediated stress. Together, results show that waxbill bill sexual dichromatism is not stable. Instead, sexual dichromatism can be modulated, and even disappear completely, due to ecology-mediated plastic adjustments in female bill colour.
Bioprocess development for biosorption of cobalt ions and Congo red from aquatic mixture using Enteromorpha intestinalis biomass as sustainable biosorbent
Authors: El-Naggar Noura El-Ahmady , Hamouda Ragaa A. , Abuelmagd Muhammad A. , Abdelgalil Soad A. 
Published: July 2021

AbstractBecause of the increased amount of cobalt and Congo red dye effluents attributable to the industrial operations, the capacity of Enteromorpha intestinalis biomass as a sustainable source to achieve significant biosorption percent for both pollutants from dual solution was assessed. A fifty batch FCCCD experiments for biosorption of cobalt ions and Congo red dye were performed. The complete removal of Congo red dye was obtained at 36th run using an initial pH value of 10, 1.0 g/L of Enteromorpha intestinalis biomass, 100 and 200 mg/L of Congo red and cobalt for a 20-min incubation time. Meanwhile, a cobalt removal percent of 85.22 was obtained at 35th run using a neutral pH of 7.0, 3.0 g/L of algal biomass, 150 and 120 mg/L of Congo red, and cobalt for a 60-min incubation time. For further illustration and to interpret how the biosorption mechanism was performed, FTIR analysis was conducted to inspect the role of each active group in the biosorption process, it can be inferred that –OH, C–H, C=O, O–SO3- and C–O–C groups were mainly responsible for Co2+ adsorption of from aqueous dual solution. Also, scan electron microscope revealed the appearance of new shiny particles biosorbed on E. intestinalis surface after the biosorption process. EDS analysis proved the presence of Co2+ on the algal surface after the biosorption process.
Assisted peritoneal dialysis: a feasible KRT modality for frail older patients with end-stage kidney disease (ESKD)
Authors: Song Qianhui , Yan Hao , Yu Zanzhe , Li Zhenyuan , Yuan Jiangzi , Ni Zhaohui , Fang Wei 
Published: July 2021

AbstractAssisted PD is used as an alternative option for the growing group of frail, older ESKD patients unable to perform their own PD. This study was undertaken to investigate the outcomes of assisted PD in older patients by comparing assisted PD patients with self-care PD patients. This study included all patients aged 70 and above who started on PD in our hospital from 2009 to 2018. Patients were followed up until death, PD cessation or to the end of the study (December 31, 2019). Risk factors associated with mortality, peritonitis and technique failure were evaluated using both cause-specific hazards and subdistribution hazards models. 180 patients were enrolled, including 106 (58.9%) males with a median age of 77.5 (77.2–81.2) years. Among the 180 patients, 62 patients (34.4%) were assisted. Patients on assisted PD group were older, more likely to be female, more prevalent in DM and CVD, with a higher Charlson score than patients undergoing self-care PD (P all < 0.05). In the multivariable analysis, assisted patients had a comparable patient survival and peritonitis-free survival compared to self-care PD patients either in the Cox or in the FG models. According to a Cox model, the use of assisted PD was associated with a lower risk of technique failure (cs-HR 0.20, 95% CI 0.04–0.76), but the association lost its statistical significance in the Fine and Gray model. Our results suggest that assisted PD could be a safe and effective KRT modality for older ESKD patients who need assistance.
High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro
Authors: Gard A. L. , Luu R. J. , Miller C. R. , Maloney R. , Cain B. P. , Marr E. E. , Burns D. M. , Gaibler R. , Mulhern T. J. , Wong C. A. , Alladina J. , Coppeta J. R. , Liu P. , Wang J. P. , Azizgolshani H. , Fezzie R. Fennell , Balestrini J. L. , Isenberg B. C. , Medoff B. D. , Finberg R. W. , Borenstein J. T. 
Published: July 2021

AbstractInfluenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as from COVID-19. A barrier to the development of effective therapeutics is the absence of a robust and predictive preclinical model, with most studies relying on a combination of in vitro screening with immortalized cell lines and low-throughput animal models. Here, we integrate human primary airway epithelial cells into a custom-engineered 96-device platform (PREDICT96-ALI) in which tissues are cultured in an array of microchannel-based culture chambers at an air–liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing. We apply this platform to influenza A virus and coronavirus infections, evaluating viral infection kinetics and antiviral agent dosing across multiple strains and donor populations of human primary cells. Human coronaviruses HCoV-NL63 and SARS-CoV-2 enter host cells via ACE2 and utilize the protease TMPRSS2 for spike protein priming, and we confirm their expression, demonstrate infection across a range of multiplicities of infection, and evaluate the efficacy of camostat mesylate, a known inhibitor of HCoV-NL63 infection. This new capability can be used to address a major gap in the rapid assessment of therapeutic efficacy of small molecules and antiviral agents against influenza and other respiratory viruses including coronaviruses.
Magnetic generation of normal pseudo-spin polarization in disordered graphene
Authors: Baghran R. , Tehranchi M. M. , Phirouznia A. 
Published: July 2021

AbstractSpin to pseudo-spin conversion by which the non-equilibrium normal sublattice pseudo-spin polarization could be achieved by magnetic field has been proposed in graphene. Calculations have been performed within the Kubo approach for both pure and disordered graphene including vertex corrections of impurities. Results indicate that the normal magnetic field $$B_z$$

B
z

produces pseudo-spin polarization in graphene regardless of whether the contribution of vertex corrections has been taken into account or not. This is because of non-vanishing correlation between the $$\sigma _z$$

σ
z

and $$\tau _z$$

τ
z

provided by the co-existence of extrinsic Rashba and intrinsic spin–orbit interactions which combines normal spin and pseudo-spin. For the case of pure graphene, valley-symmetric spin to pseudo-spin response function is obtained. Meanwhile, by taking into account the vertex corrections of impurities the obtained response function is weakened by several orders of magnitude with non-identical contributions of different valleys. This valley-asymmetry originates from the inversion symmetry breaking generated by the scattering matrix. Finally, spin to pseudo-spin conversion in graphene could be realized as a practical technique for both generation and manipulation of normal sublattice pseudo-spin polarization by an accessible magnetic field in a easy way. This novel proposed effect not only offers the opportunity to selective manipulation of carrier densities on different sublattice but also could be employed in data transfer technology. The normal pseudo-spin polarization which manifests it self as electron population imbalance of different sublattices can be detected by optical spectroscopy measurements.
Quantification of muscles activations and joints range of motions during oil palm fresh fruit bunch harvesting and loose fruit collection
Authors: Teo Yu Xuan , Chan Yon Sin , Gouwanda Darwin , Gopalai Alpha Agape , Nurzaman Surya Girinatha , Thannirmalai Subbiah 
Published: July 2021

AbstractAlthough global demand for palm oil has been increasing, most activities in the oil palm plantations still rely heavily on manual labour, which includes fresh fruit bunch (FFB) harvesting and loose fruit (LF) collection. As a result, harvesters and/or collectors face ergonomic risks resulting in musculoskeletal disorder (MSD) due to awkward, extreme and repetitive posture during their daily work routines. Traditionally, indirect approaches were adopted to assess these risks using a survey or manual visual observations. In this study, a direct measurement approach was performed using Inertial Measurement Units, and surface Electromyography sensors. The instruments were attached to different body parts of the plantation workers to quantify their muscle activities and assess the ergonomics risks during FFB harvesting and LF collection. The results revealed that the workers generally displayed poor and discomfort posture in both activities. Biceps, multifidus and longissimus muscles were found to be heavily used during FFB harvesting. Longissimus, iliocostalis, and multifidus muscles were the most used muscles during LF collection. These findings can be beneficial in the design of various assistive tools which could improve workers' posture, reduce the risk of injury and MSD, and potentially improve their overall productivity and quality of life.
Substituted 1,2,3-triazoles: a new class of nitrification inhibitors
Authors: Taggert Bethany I. , Walker Charlie , Chen Deli , Wille Uta 
Published: July 2021

AbstractNitrogen (N) fertilisers amended with nitrification inhibitors can increase nitrogen use efficiencies in agricultural systems but the effectiveness of existing commercial inhibitor products, including 3,4-dimethylpyrazole phosphate (DMPP), is strongly influenced by climatic and edaphic factors. With increasing pressure to reduce the environmental impact of large-scale agriculture it is important to develop new nitrogen-stabilising products that can give reliable and consistent results, particularly for warmer climatic conditions. We synthesised a library of 17 compounds featuring a substituted 1,2,3-triazole motif and performed laboratory incubations in two south-eastern Australian soils. In the neutral (pH 7.3) soil, the compounds N002, N013, N016 and N017, which possess short non-polar alkyl or alkynyl substituents at the triazole ring, retained NH4+-N concentrations at 35 °C soil temperature to a better extent (P < 0.001) than DMPP. In the alkaline soil (pH 8.8) N013 performed better with regards to NH4+-N retention (P = 0.004) than DMPP at 35 °C soil temperature. Overall, our data suggest that substituted 1,2,3-triazoles, which can be synthesized with good yields and excellent atom economy through 1,3-dipolar cycloaddition from readily available starting materials, are promising nitrification inhibitors performing similar to, or better than DMPP, particularly at elevated soil temperatures.