bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creativity in public involvement: supporting authentic collaboration and inclusive research with seldom heard voices
Authors: Broomfield Katherine , Craig Claire , Smith Sarah , Jones Georgina , Judge Simon , Sage Karen 
Published: March 2021

Abstract
Background
The role of public involvement (PI) in healthcare research is growing in importance and it is imperative that researchers continuously reflect on how to promote the inclusion of patients and service users in the design and delivery of research. PI offers a mechanism for end-users to be involved planning, executing, and reporting research. Some patient groups, including people who have communication difficulties, may struggle to engage in the methods traditionally employed to promote PI engagement such as questionnaires and focus groups.

Methods
This article describes a longitudinal case-study of a PI group, consisting of people who have communication difficulties, for a patient-reported outcome development project. Creative methods, informed by the participatory design principles of enacting, seeing and doing, were introduced stepwise into seven PI meetings. Data from video and visual minutes were used to evaluate the impact of the methods, following each group. Feedback, in the form of verbal and visual outputs taken directly from group meeting minutes, along with vignettes evidenced the impact of the methods on the project and group members.

Results
Creative methods enabled the PI group members to successfully contribute in meetings, to interact dynamically and to engage with the aims and processes of the research project. Their involvement facilitated the development of accessible recruitment materials, informed data analysis and supported the dissemination of project outputs. Employing creative methods also enabled both PI group members and the academic team to reflect on their own roles within the research project and the impact that their active involvement in the PI group has had on their personal development and perspectives on research.

Conclusion
The impact of using creative methods in PI for this patient-reported outcome measure (PROM) development project improved collaboration and understanding between PI members and the academic team. The authentic engagement of people who have communication difficulties in PI generated a more accessible project in terms of both process and impact. Creativity has applicability beyond people whose communication is non-verbal; it should be harnessed by research teams to identify and breakdown barriers to involvement to develop outcome tools that reflect the diversity of our populations.
Titanium mesh and pedicled buccal fat pad for the reconstruction of maxillary defect: case report
Authors: Yoon Joo-Hyung , Park Young-Wook , Kim Seong-Gon 
Published: March 2021

AbstractBackgroundPedicled buccal fat pad (PBFP) has been used for the reconstruction of small-sized maxillary defects but cannot be used without hard tissue support on the defect larger than 4 cm × 4 cm × 3 cm.Case presentationA 64-year-old man had a history of squamous cell carcinoma of the left maxilla. After removal of the posterior maxilla, a complex bone defect (size, 5 cm × 4 cm × 3 cm) was immediately reconstructed using PBFP combined with a titanium mesh. A pinpoint fistula was found in the left palatal region 1 month after the surgery and was treated with a palatal sliding flap. There were no further complications during the follow-up.ConclusionThe present technique demonstrated that PBFP combined with a titanium mesh could be used for the reconstruction of complex maxillary defect (size, 5 cm × 4 cm × 3 cm) without additional bone graft.
Gamification and active learning in higher education: is it possible to match digital society, academia and students' interests?
Authors: Murillo-Zamorano Luis R. , López Sánchez José Ángel , Godoy-Caballero Ana Luisa , Bueno Muñoz Carmen 
Published: March 2021

AbstractThis study aims to examine whether it is possible to match digital society, academia and students interests in higher education by testing to what extent the introduction of gamification into active learning setups affects the skills development demanded by the workplace of the digital society of the twenty-first century, the academic achievement standards claimed by the academia, and the satisfaction with the learning process required by the students. Our results provide statistically significant empirical evidence, concluding that the generation of a co-creative and empowered gameful experience that supports students' overall value creation yields to satisfactory active learning setups without any loss of academic achievement, and allowing to develop a series of skills especially relevant for twenty-first century professionals.
Methods of measuring presynaptic function with fluorescence probes
Authors: Jang Yeseul , Kim Sung Rae , Lee Sung Hoon 
Published: March 2021

AbstractSynaptic vesicles, which are endogenous to neurotransmitters, are involved in exocytosis by active potentials and release neurotransmitters. Synaptic vesicles used in neurotransmitter release are reused via endocytosis to maintain a pool of synaptic vesicles. Synaptic vesicles show different types of exo- and endocytosis depending on animal species, type of nerve cell, and electrical activity. To accurately understand the dynamics of synaptic vesicles, direct observation of synaptic vesicles is required; however, it was difficult to observe synaptic vesicles of size 40–50 nm in living neurons. The exo-and endocytosis of synaptic vesicles was confirmed by labeling the vesicles with a fluorescent agent and measuring the changes in fluorescence intensity. To date, various methods of labeling synaptic vesicles have been proposed, and each method has its own characteristics, strength, and drawbacks. In this study, we introduce methods that can measure presynaptic activity and describe the characteristics of each technique.
Comprehensive Identification of Pathogenic Gene Variants in Patients With Neuroendocrine Disorders
Authors: Vishnopolska Sebastian Alexis , Mercogliano Maria Florencia , Camilletti Maria Andrea , Mortensen Amanda Helen , Braslavsky Debora , Keselman Ana , Bergadá Ignacio , Olivieri Federico , Miranda Lucas , Marino Roxana , Ramírez Pablo , Pérez Garrido Natalia , Patiño Mejia Helen , Ciaccio Marta , Di Palma Maria Isabel , Belgorosky Alicia , Martí Marcelo Adrian , Kitzman Jacob Otto , Camper Sally Ann , Pérez-Millán Maria Ines 
Published: March 2021

AbstractPurposeCongenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the prevalence of mutations in known and candidate genes for this disorder. It could also increase the proportion of patients that receive a genetic diagnosis.MethodsWe conducted target panel genetic screening using single-molecule molecular inversion probes sequencing to assess the frequency of mutations in known hypopituitarism genes and new candidates in Argentina. We captured genomic deoxyribonucleic acid from 170 pediatric patients with CH, either alone or with other abnormalities. We performed promoter activation assays to test the functional effects of patient variants in LHX3 and LHX4.ResultsWe found variants classified as pathogenic, likely pathogenic, or with uncertain significance in 15.3% of cases. These variants were identified in known CH causative genes (LHX3, LHX4, GLI2, OTX2, HESX1), in less frequently reported genes (FOXA2, BMP4, FGFR1, PROKR2, PNPLA6) and in new candidate genes (BMP2, HMGA2, HNF1A, NKX2-1).ConclusionIn this work, we report the prevalence of mutations in known CH genes in Argentina and provide evidence for new candidate genes. We show that CH is a genetically heterogeneous disease with high phenotypic variation and incomplete penetrance, and our results support the need for further gene discovery for CH. Identifying population-specific pathogenic variants will improve the capacity of genetic data to predict eventual clinical outcomes.
Supramolecular Thermocells Based on Thermo-Responsiveness of Host–Guest Chemistry
Authors: Zhou Hongyao , Yamada Teppei , Kimizuka Nobuo 
Published: March 2021

Abstract
Molecular machines leverage sub-nanometer level intermolecular forces and host–guest interactions to perform useful work observable at the macroscopic level. The development of molecular machines for the past three decades has resulted in successful applications from molecular switches, chemical sensing, to actuators. However, the application of molecular machines and supramolecular chemistry in energy production is rare and has been highly anticipated. This review introduces the advancement of supramolecular thermocells, initially proposed by our research group, which use thermo-responsive host–guest interaction to regenerate electrochemical energy from low-grade heat sources. The selective transport of a redox species carried by the host molecule from the cooled to the heated electrode creates a concentration gradient of the guest redox species and provides an additional voltage to the thermocell. The key properties of useful host molecules for the supramolecular thermocells are: (1) high selectivity of the host molecule to capture either the oxidized or reduced species as the guest, (2) inhibition of the redox activity after the encapsulation, (3) large entropy change at the release of the guest molecule in response to the temperature changes. Design principles and promising candidates of molecular machines for the future development of supramolecular thermocells are presented here.
Just Dance? Teachers Perspectives on Implementing a Daily Classroom Physical Activity Break
Authors: Janssen Mirka , van den Berg Vera , de Groot Annerose , Singh Amika 
Published: March 2021

ABSTRACT
A regular short physical activity break in the classroom may improve classroom behavior. The current study reports on the results of the implementation of a daily 10-min Just Dance break in the classroom. A total of 31 Dutch primary school teachers agreed to participate in the study. We collected data on the frequency of the use of the Just Dance breaks via an online registration system. Data on the long-term barriers and facilitators of the implementation were collected using two online questionnaires. In addition, we held five interviews with teachers to elucidate data on barriers and facilitators. The results show that none of the teachers maintained the Just Dance breaks on a daily basis, and only 19% (n = 6) of the teachers on a weekly basis (i.e., one to three times a week). According to all participating teachers, a lack of time was the primary barrier to implement Just Dance breaks on a daily basis. Teachers who did not maintain Just Dance breaks on a weekly basis also experienced difficulties in 1) keeping all pupils engaged during the full 10-min Just Dance break or 2) getting the pupils focused again after the Just Dance break. Teachers who maintained the Just Dance breaks on a weekly basis provided several practical recommendations for a more sustainable implementation process. This study shows that the implementation process of daily Just Dance breaks is challenging. We recommend providing teachers with professional support when implementing physical activity breaks in their daily program.
YouTube Searches for Anterior Cruciate Ligament Injury Promote Biased, Low-Quality Videos
Authors: Ward Brittany , Lin Alex , Lin Jasmine , Warren Christopher , Mattern Patrick , Paskhover Boris , Chu Alice 
Published: March 2021

ABSTRACT

Purpose
YouTube is the second most accessed website worldwide and is increasingly used by patients to search for medical knowledge. This study aims to evaluate the bias and overall quality of anterior cruciate ligament (ACL) YouTube videos.

Methods
A list of 40 videos was compiled using the terms “ACL tear” and “ACL reconstruction.” The DISCERN criteria, which utilizes a 5-point Likert scale, was used to evaluate the bias and overall quality of each and assign a DISCERN score (DS). The presence of a US board-certified orthopedic surgeon, publisher type, publication date, number of views, and video length were recorded. Additional ACL videos on the websites of the American Orthopaedic Society for Sports Medicine and the American Academy of Orthopaedic Surgeons were rated using DISCERN.

Results
Mean bias DS for “ACL reconstruction” was 1.85 ± 1.57, and that for “ACL tear” was 2.30 ± 1.78. Mean overall quality DS was 2.05 ± 1.19 for “ACL reconstruction” and 2.00 ± 1.12 for “ACL tear.” Unique videos received 25,198,961 total views and were an average of 6.83 ± 7.20 min and 5.61 ± 3.21 yr old. Most videos were posted by hospitals, followed by companies. Fifty-three percent of videos included commentary by US-board certified orthopedic surgeons, and the bias and overall quality DS were significantly higher than the remaining videos (P < 0.05). Videos from the American Orthopaedic Society for Sports Medicine and American Academy of Orthopaedic Surgeons had a bias DS of 3.00 ± 0.00 and overall DS of 2.00 ± 0.00.

Discussion
The general public does not have access to unbiased, high-quality ACL injury videos, despite an increasing need for access to educational videos. Physicians and professional societies are educated resources who can help increase public access and availability to unbiased, high-quality video medical information online.
Effects of Exercise during Weight Loss Maintenance on Appetite Regulation in Women
Authors: Foright Rebecca , Halliday Tanya M. , Melanson Edward L. , Hild Allison , Legget Kristina T. , Tregellas Jason R. , Cornier Marc-Andre 
Published: March 2021

ABSTRACT
Exercise is accepted as a method to improve weight loss maintenance; however, the mechanisms by which this occurs have yet to be elucidated. In this pilot study, 13 women with obesity underwent a structured weight loss program (goal 8%–10% weight loss) and were then randomized to either a 12-wk diet (n = 7) or an aerobic exercise training (n = 6) intervention aimed at maintaining weight loss. At baseline, post–weight loss, and following the weight loss maintenance interventions, measurements of appetite (hunger and satiety) and appetite-regulating hormones (leptin, ghrelin, peptide tyrosine tyrosine, and glucagon-like peptide 1) were obtained after an overnight fast and for 3 h after a standardized test meal. Ad libitum energy intake was measured at a lunch meal. During the weight loss phase, participants lost 9.1% ± 1.1% of baseline body weight. Participants in both groups maintained weight loss during the 12-wk weight loss maintenance intervention. No differences in fasting leptin (P = 0.68) or in ghrelin (P = 0.30), peptide tyrosine tyrosine (P = 0.93), and glucagon-like peptide 1 (P = 0.98) area under the curve were detected between groups. Similarly, ratings of hunger (P = 0.99) and satiety (P = 0.65) area under the curve after the standardized test meal also did not differ between the groups nor did ad libitum energy intake at lunch. In summary, the 12-wk diet and exercise interventions were equally effective at maintaining weight loss in women, and no differences in measures of appetite regulation and food intake were found.
Archaeological research as a benefit for the local community
Authors: Radziwiłko Katarzyna , Kutyło Łukasz , Kołodziejczyk Piotr 
Published: March 2021

Archaeological research as a benefit for the local community. Southern Jordan in the preliminary socioarchaeological study
Starting an archaeological research is not only the beginning of gathering new scientific data for academic analysis. The role of a scientist is not only to build the ‘tower of knowledge,’ but also to make it beneficial to people. Therefore, archaeological projects should also vastly contribute to the promotion of the heritage of the region and its modern value and to the development of tourism, education and local community activities. Understanding the local community and its view on the historical heritage, as well as on archaeological research seems to be a very important aspect of this type of activity. It will not only allow to identify potential risks and create a plan of regular research, excavations, as well as future maintenance. As a benefit of the sociological study, the future revitalization of the area will occur. This outcome may be an important extension of theoretical and practical principles of global heritage protection and may become a standard solution based on the belief that cultural heritage can be a factor of local community development and prosperity.
Collateralized Networks
Authors: Ghamami Samim , Glasserman Paul , Young H. Peyton 
Published: March 2021

This paper studies the spread of losses and defaults in financial networks with two interrelated features: collateral requirements and alternative contract termination rules. When collateral is committed to a firm’s counterparties, a solvent firm may default if it lacks sufficient liquid assets to meet its payment obligations. Collateral requirements can, thus, increase defaults and payment shortfalls. Moreover, one firm may benefit from the failure of another if the failure frees collateral committed by the surviving firm, giving it additional resources to make other payments. Contract termination at default may also improve the ability of other firms to meet their obligations through access to collateral. As a consequence of these features, the timing of payments and collateral liquidation must be carefully specified to establish the existence of payments that clear the network. Using this framework, we show that dedicated collateral may lead to more defaults than pooled collateral, we study the consequences of illiquid collateral for the spread of losses through fire sales, we compare networks with and without selective contract termination, and we analyze the impact of alternative resolution and bankruptcy stay rules that limit the seizure of collateral at default. Under an upper bound on derivatives leverage, full termination reduces payment shortfalls compared with selective termination. This paper was accepted by Kay Giesecke, finance.
Large abdominal hernia repair with closed incision negative pressure therapy: a case series
Authors: Wang Edward , Archer Leigh , Foster Amanda , Ballal Mohammed 
Published: March 2021

Objective: A major challenge of large abdominal incisional hernia repair is the high rates of wound complications. Closed incision negative pressure therapy (CINPT) can offer many treatment advantages in the management of these wounds and has been shown to reduce complications for other postoperative incisions. This study assesses the wound outcomes for hernia repair patients receiving CINPT. Method: A six-year retrospective case series of patients who had undergone large abdominal incisional hernia repair wounds treated with CINPT was conducted. Outcomes for patients treated with CINPT were compared with patients who had not received CINPT acting as a control. Results: A total of 23 patients were treated with CINPT after hernia repair and compared with 12 patients in the control group. A statistically significant decreased rate of return to theatre (odds ratio: 0.12) was found in this study. Non-significant reductions in wound infection, seroma and wound dehiscence were also seen. No adverse events with CINPT therapy were reported. Conclusions: CINPT, when used after large abdominal incisional hernia repair, may help in the prevention of wound complications.
High-speed silicon Michelson interferometer modulator and streamlined IMDD PAM-4 transmission of Mach-Zehnder modulators for the 2 μm wavelength band
Authors: Cao Wei , Liu Shenghao , Littlejohns Callum G. , Thomson David J. , Nedeljkovic Milos , Zhang Weiwei , Li Ke , Banakar Mehdi , Tran Ying , Yan Xingzhao , Du Han , Ren Zhengqi , Gardes Frederic , Reed Graham T. , Mashanovich Goran Z. 
Published: March 2021

We demonstrate high-speed silicon modulators optimized for operating at the wavelength of 2 μm. The Mach-Zehnder interferometer (MZI) carrier-depletion modulator with 2 mm phase shifter has a single-arm modulation efficiency (V
π
·L
π
) of 2.89 V·cm at 4 V reverse bias. Using a push-pull configuration it operates at a data rate of 25 Gbit/s OOK with an extinction ratio of 6.25 dB. We also proposed a mathematically-analysed streamlined IMDD PAM-4 scheme and successfully demonstrated a 25 Gbit/s datarate PAM-4 with the same 2 mm modulator. A Michelson interferometer carrier-depletion modulator with 0.5 mm phase shift length has also been shown with modulation efficiency (V
π
·L
π
) of 1.36 V·cm at 4 V reverse bias and data rate of 20 Gbit/s OOK. The Michelson interferometer modulator performs similarly to a Mach-Zehnder modulator with twice the phase shifter length.
A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?
Authors: Jittamala Podjanee , Monteiro Wuelton , Smit Menno R. , Pedrique Belen , Specht Sabine , Chaccour Carlos J. , Dard Céline , Del Giudice Pascal , Khieu Virak , Maruani Annabel , Failoc-Rojas Virgilio E. , Sáez-de-Ocariz Marimar , Soriano-Arandes Antoni , Piquero-Casals Jaime , Faisant Anne , Brenier-Pinchart Marie-Pierre , Wimmersberger David , Coulibaly Jean T. , Keiser Jennifer , Boralevi Franck , Sokana Oliver , Marks Michael , Engelman Daniel , Romani Lucia , Steer Andrew C. , von Seidlein Lorenz , White Nicholas J. , Harriss Eli , Stepniewska Kasia , Humphreys Georgina S. , Kennon Kalynn , Guerin Philippe J. , Kobylinski Kevin C. 
Published: March 2021

BackgroundOral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg.Methodology/Principal findingsA systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported.Conclusions/SignificanceExisting limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance.