bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response Strategies for Demand Surges in Last‐Mile Logistics: Managing Delivery Efficiency in Volatile Environments
Authors: Suzuki Yoshinori , Chen Haozhe , Faires Christopher 
Published: December 2024

ABSTRACTLast‐mile logistics firms are facing increasingly volatile environments in which they must constantly cope with demand fluctuations. This study provides insights into how last‐mile logistics firms can effectively respond to sudden demand surges caused by unexpected events. Based on the literature review and practitioner interviews, we identify six popular last‐mile logistics response strategies and compare their effectiveness. We first develop a theoretical framework that can assess the effectiveness of multiple response strategies systematically by utilizing a well‐known transport economics theory, economies of scale. We then conduct a series of simulation experiments to (1) empirically evaluate the performance of the six strategies using our framework and (2) examine if the best‐performing strategy(s) differs from one operating condition to another using the contingency theory perspective. Results suggest that many popular strategies used in practice are “non‐viable” ones that can result in diseconomies of scale and reduce firms' competitiveness. Results also suggest that the set of “best” and “viable” strategies that can bring competitive advantages to firms varies from one firm to another depending on the firm's operating conditions.
Legumes as a Substitute for Red and Processed Meat, Poultry or Fish, and the Risk of Non‐Alcoholic Fatty Liver Disease in a Large Cohort
Authors: Langmann Fie , Ibsen Daniel B. , Johnston Luke W. , Perez‐Cornago Aurora , Dahm Christina C. 
Published: December 2024

ABSTRACTBackgroundDietary recommendations have globally shifted towards promoting the consumption of legumes as an environmentally friendly and healthy source of protein. This study investigated the replacement of red and processed meat, poultry or fish for equal amounts of legumes on the risk of non‐alcoholic fatty liver disease (NAFLD).MethodsUK Biobank participants who completed ≥ 2 dietary assessments and had complete covariate information were included in the analyses (N = 124,546). Information on dietary intake was collected using two to five 24‐h dietary assessments. Incident cases of NAFLD were determined through linkage to the National Health Service registries. The rate of developing NAFLD when replacing 80 g/week of red and processed meat, poultry or fish with legumes was estimated using multivariable‐adjusted Cox proportional hazards regression.ResultsDuring follow‐up (median 10.49, IQR: 10.4–10.9 years), 1205 individuals developed NAFLD. Replacing 80 g/week of red and processed meat or poultry with legumes was associated with 4% and 3% lower rates of NAFLD, respectively (red and processed meat HR: 0.96, 95% CI: 0.94; 0.98; poultry HR: 0.97, 95% CI: 0.95; 0.99). Replacing 80 g/week of fish with legumes was not associated with NAFLD (fish HR: 0.98, 95% CI: 0.96; 1.00). Results did not change markedly after adjustment for BMI.ConclusionsConsuming one serving of legumes weekly instead of red and processed meat or poultry was associated with a slightly lower rate of NAFLD, while consuming legumes instead of fish did not show an association with NAFLD. Further research in cohorts with higher legume consumption is needed to confirm these findings.
Sustainability or Greenwashing: Evidence from the Asset Market for Industrial Pollution
Authors: DUCHIN RAN , GAO JANET , XU QIPING 
Published: December 2024

ABSTRACTWe study the asset market for pollutive plants. Firms divest pollutive plants in response to environmental pressures. Buyers are firms facing weaker environmental pressures that have supply chain relationships or joint ventures with the sellers. While pollution levels do not decline following divestitures, sellers highlight their sustainable policies in subsequent conference calls, earn higher returns as they sell more pollutive plants, and benefit from higher Environmental, Social, and Governance (ESG) ratings and lower compliance costs. Overall, the asset market allows firms to redraw their boundaries in a manner perceived as environmentally friendly without real consequences for pollution but with substantial gains from trade.
Melatonin, an Antitumor Necrosis Factor Therapy
Authors: Álvarez‐López Ana Isabel , Cruz‐Chamorro Ivan , Lardone Patricia Judith , Bejarano Ignacio , Aspiazu‐Hinostroza Karla , Ponce‐España Eduardo , Santos‐Sánchez Guillermo , Álvarez‐Sánchez Nuria , Carrillo‐Vico Antonio 
Published: December 2024

ABSTRACTTumor necrosis factor (TNF) is a biomarker of inflammation whose levels are elevated in patients with several diseases associated with dysregulation of the immune response. The main limitations of currently used anti‐TNF therapies are the induction of immunodepression, which in many cases leads to serious adverse effects such as infection and cancer, and the inability to cross the blood‐brain barrier in neuroinflammatory conditions. Melatonin, in addition to being a chronobiotic compound, is widely known for its antioxidant and immunomodulatory capacity to control inflammatory processes in different pathological contexts. The aim of the present review is to address human‐based studies that describe the effect of melatonin on TNF production. The review includes all the articles published in PubMed databases until April 15, 2024. After depuration, 45 studies were finally included in the review, 23 related to the in vitro action of melatonin in human cells and 22 in vivo studies in humans. Most of the data reviewed support the idea that melatonin has an immunosuppressive effect on TNF levels, which, together with its low toxicity profile, low cost, and ability to cross the blood‐brain barrier, points to melatonin as a potential anti‐TNF therapy. Therefore, improving our knowledge of the action of melatonin in regulating TNF through appropriate clinical trials would reveal the true potential of this molecule as a possible anti‐TNF therapy.
A feature‐based pavement image registration method for precise pavement deterioration monitoring
Authors: Yang Zhongyu , Mohammadi Mohsen , Wang Haolin , Tsai Yi‐Chang (James) 
Published: December 2024

AbstractOver the past decade, pavement imaging systems, particularly 3D laser technology, have been widely adopted by transportation agencies for network‐level pavement condition evaluations. State Highway Agencies, including Georgia Department of Transportation (DOT), Florida DOT, and Texas DOT, have been collecting pavement images for over 5 years. However, these multi‐year pavement images have not been fully utilized for analyzing detailed pavement deterioration. One challenge is the accurate and efficient registration of multi‐temporal pavement images. This study pioneers the use of feature‐based methods to address this challenge. It evaluates various feature‐based image registration methods, including both state‐of‐the‐art and novel combinations of feature detectors and descriptors. These methods are rigorously assessed using hybrid “step‐by‐step” and “end‐to‐end” performance evaluation metrics, with a ground reference dataset containing 100 pavement image pairs featuring diverse crack types and varying year gaps. The results confirm the feasibility of using feature‐based techniques to register multi‐temporal pavement images. A novel combination of the AKAZE detector and the Binary Robust Independent Elementary Features (BRIEF) descriptor was identified as the best‐performing method, successfully registering 96 out of 100 image pairs. This advancement enables pavement engineers to accurately monitor pavement deterioration using multi‐temporal images.
Evaluation of Perceived Competence and Satisfaction in Neurogastroenterology and Motility Training During the Gastroenterology Fellowship in Spain
Authors: Alcala‐Gonzalez Luis G. , Alcedo Javier , Santander Cecilio , Suárez José Francisco , Serra Jordi 
Published: December 2024

ABSTRACTIntroductionWe evaluated the level of achievement of the published recommendations of the European and American neurogastroenterology and motility (NGM) Societies, on the competence in managing NGM disorders in a European Country with regulated gastroenterology training program.MethodsWe conducted a nationwide survey to gastroenterologists in Spain. Information regarding demographics, training center characteristics, NGM training, self‐reported interest, satisfaction with the Tier 1 skills recommended by the ANMS‐ESNM, and perceived competence in the diagnosis and management of diseases in the spectrum of NGM was obtained.ResultsSurveys of 222 participants were analyzed (age 31 ± 3 years, 68% female, 77% specialists, 23% residents). During GI training, the average time spent on NGM was 4 (IQR 2–8) weeks, and 14% of participants reported they did not have any (0 weeks total) specific time dedicated to NGM in their training center. Ninety‐two (41%) participants reported low satisfaction in the NGM skills obtained during training. There was a disparity in the skills acquired, being greatest for gastroesophageal reflux disease and lowest for colonic inertia (97% and 19% confident, respectively). Multiple regression analysis showed that the weeks of specific training in NGM was an independent factor associated with perceived satisfaction in the skills obtained (IC 95% 1.8–2.9, p < 0.001).ConclusionOur data reveal a relevant deficit in training on NGM during gastroenterology fellowships and highlight the urgent need to extend and standardize the time allocated to learning NGM in the training programs, as training time correlates with satisfaction in the skills obtained.
Mean Nocturnal Baseline Impedance May Be Greater Than 2500 Ohms in Chinese Patients With GERD
Authors: Wang Dongke , Duan Chaofan , Zhang Xiaohao , Xu Junying , Hou Xiaohua , Xiang Xuelian 
Published: December 2024

ABSTRACTBackgroundAccording to the Lyon Consensus 2.0, mean nocturnal baseline impedance (MNBI) greater than 2500 Ω is considered evidence against gastroesophageal reflux disease (GERD). However, we have observed that a subset of GERD patients presents with MNBI exceeding 2500 Ω.AimsTo investigate MNBI characteristics in Chinese GERD patients, identify clinical features of those with normal MNBI, and examine factors influencing MNBI values.MethodsWe retrospectively investigated 259 patients with typical reflux symptoms. Demographics, symptoms, proton pump inhibitor (PPI) response, esophageal motility parameters were compared between patients with different AET levels and MNBI levels.ResultsAmong the cohort, 38.2% had AET 4%–6%, and 37.5% had AET > 6%. Notably, 95.2% of patients with AET < 4%, 49.5% with AET 4%–6%, and 17.6% with AET > 6% had MNBI > 2500 Ω. Independent risk factors for MNBI > 2500 Ω included the number and duration of supine acid reflux and lower esophageal sphincter (LES) resting pressure. In GERD patients with heartburn, patients with MNBI ≤ 2500 Ω had higher PPI response than MNBI > 2500 Ω (81.1% vs. 55.6%, p = 0.009).ConclusionsApproximately one‐third of Chinese GERD patients have an MNBI > 2500 Ω. The thresholds of MNBI for supporting or ruling out GERD in the Chinese population should be adjusted. MNBI values are independently predicted by the severity of supine acid reflux and the LES resting pressure. GERD patients with mild supine acid reflux may still exhibit normal MNBI levels. Patients with lower MNBI values tend to show better responses to PPI therapy.
Over‐The‐Top Technique for ACL Reconstruction: Advantages, Disadvantages, and Postoperative Complications
Authors: Du Haocheng , Li Lin , Qin Ziwen , Guo Jiang , Zhang Xintao 
Published: December 2024

ABSTRACTAnterior cruciate ligament (ACL) injuries are the most common knee joint injuries related to sports activities in clinical practice. For treating ACL injuries, anatomical reconstruction surgery is often the preferred method. The over‐the‐top (OTT) technique is a surgical approach that eliminates the need for creating a femoral tunnel. According to the existing literature, the OTT technique offers distinct advantages, particularly for skeletally immature individuals and in revision cases. Currently, femoral tunnel failure is the most common cause of ACL reconstruction failure, which can lead to less than optimal postoperative performance of the ACL and a higher likelihood of needing a revision. Additionally, mistakes in the placement of the femoral tunnel and the subsequent risk of tunnel enlargement can increase the complexity of revision procedures, ultimately reducing the long‐term clinical effectiveness for patients. In contrast, the OTT technique has shown excellent biomechanical performance, avoids the need for bone tunnels, is economically practical, and has been proven to provide satisfactory therapeutic outcomes both in the short and long term, especially for skeletally immature individuals and in revision cases. The OTT technique is deemed a safe and effective surgical method for treating ACL injuries. In summary, the OTT technique has unique benefits for skeletally immature individuals and in revision cases, making it a viable option worth considering.Level of evidence V.
CsCIPK20 Improves Tea Plant Cold Tolerance by Modulating Ascorbic Acid Synthesis Through Attenuation of CsCSN5‐CsVTC1 Interaction
Authors: Di Taimei , Wu Yedie , Wang Jie , He Mingming , Huang Jianyan , Li Nana , Hao Xinyuan , Ding Changqing , Zeng Jianming , Yang Yajun , Wang Xinchao , Wang Lu 
Published: December 2024

ABSTRACTLow temperature is a limiting environmental factor for tea plant growth and development. CBL‐interacting protein kinases (CIPKs) are important components of the calcium pathway and involved in plant development and stress responses. Herein, we report the function and regulatory mechanisms of a low‐temperature‐inducible gene, CsCIPK20, in tea plants. The overexpression of CsCIPK20 in Arabidopsis and its transient knockdown in tea plants confirmed its positive role in cold resistance. Notably, the ascorbic acid (AsA) levels increased in the overexpression lines and decreased in the CsCIPK20 knockdown tea plants under freezing stress. Transcriptomic analysis revealed that genes involved in flavonoid metabolism, glutathione metabolism, and AsA biosynthesis were significantly regulated by CsCIPK20. Furthermore, we found that CsCSN5, a key component of the COP9 signalosome, interacted with CsCIPK20 to mediate CsCIPK20 degradation. CsCSN5 interacted with CsVTC1, a key enzyme in AsA biosynthesis, and mediated CsVTC1 degradation. Knockdown of CsVTC1 in tea plants enhanced sensitivity to low temperature. Moreover, we demonstrated that CsCIPK20 competed with CsVTC1 to bind to CsCSN5, which protected CsVTC1 from degradation mediated by CsCSN5 and contributed to AsA accumulation. Overall, our findings uncovered a mechanistic framework through which the CsCIPK20‐CsCSN5‐CsVTC1 module mediated AsA accumulation and low‐temperature resistance in tea plants.
Art in movement, art as movement: Collective action and collective gathering for intangible cultural heritage sustainability
Authors: Rincón‐Unigarro Camilo , Jaramillo Andrés , Riascos Carlos , Checa Guisella , da Costa Silvia , López‐López Wilson , Páez Darío , Díaz‐Fuentes Laura , Gómez‐Ortiz Daniela , Ordoñez Camila , Ortíz Isabella , Velásquez Valeria , Venegas Patricia , Jaramillo Juan‐Camilo 
Published: December 2024

AbstractCarnaval de Negros y Blancos is a mixed‐race festive act inscribed on UNESCO's list of intangible cultural heritage (ICH). It hosts collective gatherings that provide opportunities for identity emergence and reaffirmation, where heritage owners lead top‐down and bottom‐up safeguarding efforts. This study aims to document the processes of collective action for sustainability, by analyzing top‐down and bottom‐up initiatives for safeguarding. We conducted a mixed‐methods study in Pasto, Colombia, using data from interviews with ICH stakeholders (n = 59) and from surveys with carnival players (n = 403). Heritage safeguarding, peacebuilding, human expression, transcendent experience, and evolving identities are the main themes within safeguarding movements. Additionally, the quality of participation in the event, either as performer or not performer at Senda del Carnaval, relates to sociocognitive and emotional processes of both social movements and collective gatherings. Findings portray ICH as a context for sustainable cities and communities, as well as increased peace, justice, and responsive institutions.
Inflammation and mechanical force‐induced bone remodeling
Authors: Jeon Hyeran Helen , Huang Xin , Rojas Cortez Leticia , Sripinun Puttipong , Lee Jung‐me , Hong Julie J. , Graves Dana T. 
Published: December 2024

AbstractPeriodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment. There is no consensus on the factors that lead to a conversion from gingivitis to periodontitis, but one possibility is the proximity of the inflammation to the bone, which promotes bone resorption and inhibits subsequent bone formation during coupled bone formation. Conversely, orthodontic tooth movement is triggered by the mechanical force applied to the tooth, resulting in bone resorption on the compression side and new bone formation on the tension side. However, the environment around orthodontic brackets readily retains dental plaque and may contribute to inflammation and bone remodeling. The immune, epithelial, stromal, endothelial and bone cells of the host play an important role in setting the stage for bone remodeling that occurs in both periodontitis and orthodontic tooth movement. Recent advancements in single‐cell RNA sequencing have provided new insights into the roles and interactions of different cell types in response to challenges. In this review, we meticulously examine the functions of key cell types such as keratinocytes, leukocytes, stromal cells, osteocytes, osteoblasts, and osteoclasts involved in inflammation‐ and mechanical force‐driven bone remodeling. Moreover, we explore the combined effects of these two conditions: mechanical force‐induced bone remodeling combined with periodontal disease (chronic inflammation) and periodontally accelerated osteogenic orthodontics (acute transient inflammation). This comprehensive review enhances our understanding of inflammation‐ and mechanical force‐induced bone remodeling.
Occupational Therapists’ Perceptions on The Training Needed for Children with Upper Limb Prosthesis
Authors: Chu Ai Reen , Jamaludin Mohd Najeb , Kadar Masne , Siaw Chui Chai 
Published: December 2024

The aim of this study was to develop and conduct content validation through expert panel discussion to develop a home-based self-care training module for children who fitted with a 3D printed hand prosthesis. A three-round Delphi technique was implemented. Round one involved 1) a literature search, and 2) a review of an existing user manual, and experiences of 12 occupational therapists specializing in pediatrics and orthopedic was obtained by rating the proposed components using a Likert scale from a range of 1 to 5 in round two of the study. An analysis of consensus, stability, and agreement was then performed according to the characteristics of relevance, clarity, simplicity and sufficiency in round three by 12 occupational therapists from each state in Peninsular Malaysia. Fleiss kappa statistical test was used to measured strength of agreement. All 12 experts completed and returned the survey where consensus was attained with a mean score of > 4 or 80% agreement. The strength of agreement obtained for each of the dimensions was almost perfect (κ= 1). Following the final round of the survey, a total of three phases, four steps, and 21 activities and items were finalized as the main components in the home-based self-care training module. The Delphi methodology allowing a strong consensus obtained on the key domains for a home-based self-care training module for children who fitted with a 3D printed hand prosthesis.
Isolation, Characterization and Identification of Purple Non Sulfur Bacteria for Cadmium Removal from Aqueous Solution
Authors: Armadi Balqis Nurul Huda , Hasmoni Siti Halimah , Shahir Shafinaz , Al Towayti Wahid Ali Hamood , Ibrahim Zaharah 
Published: December 2024

Cadmium (Cd) contamination in aquatic ecosystems poses serious environmental and health challenges due to its high toxicity and non-biodegradable nature. Conventional methods for Cd removal are often expensive and environmentally unsustainable, highlighting the need for alternative bioremediation approaches. Purple Non-Sulfur Bacteria (PNSB) have shown potential in heavy metal biosorption, but their application in Cd removal requires further exploration.This study is focused on the isolation, characterization and identification of purple non sulfur bacteria (PNSB) isolated from Kim Kim River, Pasir Gudang, Johor and its ability in removal of Cadmium from aqueous solution. PNSB was isolated and identifies based on morphological, pigment analysis and 16S rRNA approaches. Rhodobacter sp. was isolated and identified and was then studied for its ability to remove Cd in different environmental conditions such as various temperature, initial Cd solution pH and microbial growth conditions. The results showed that the best condition for Cd biosorption by Rhodobacter sp. was at 25°C, initial cadmium pH of 5.5 and facultative light incubation condition with 37.77% removal of Cd from aqueous solution. In conclusion, Rhodobacter s sp. isolated from Kim Kim River has the potential to remove cadmium from aqueous solution.
Spectral convergence in large finite resonator arrays: The essential spectrum and band structure
Authors: Ammari Habib , Davies Bryn , Hiltunen Erik Orvehed 
Published: December 2024

AbstractWe show that the resonant frequencies of a system of coupled resonators in a truncated periodic lattice converge to the essential spectrum of the corresponding infinite lattice. We use the capacitance matrix as a model for fully coupled subwavelength resonators with long‐range interactions in three spatial dimensions. For one‐, two‐ or three‐dimensional lattices embedded in three‐dimensional space, we show that the (discrete) density of states (DOS) for the finite system converges in distribution to the (continuous) DOS of the infinite system. We achieve this by proving a weak convergence of the finite capacitance matrix to corresponding (translationally invariant) Toeplitz matrix of the infinite structure. With this characterisation at hand, we use the truncated Floquet transform to introduce a notion of spectral band structure for finite materials. This principle is also applicable to structures that are not translationally invariant and have interfaces. We demonstrate this by considering examples of perturbed systems with defect modes, such as an analogue of the well‐known interface Su–Schrieffer–Heeger model.
Asymptotic growth rate of solutions to level‐set forced mean curvature flows with evolving spirals
Authors: Mitake Hiroyoshi , Tran Hung V. 
Published: December 2024

AbstractHere, we study a level‐set forced mean curvature flow with evolving spirals and the homogeneous Neumann boundary condition, which appears in a crystal growth model. Under some appropriate conditions on the forcing term, we prove that the solution is globally Lipschitz. We then study the large time average of the solution and deduce the asymptotic growth rate of the crystal. Some large time behavior results of the solution are obtained.