bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polarimetric spatio-temporal light transport probing
Authors: Baek Seung-Hwan , Heide Felix 
Published: December 2021

Light emitted from a source into a scene can undergo complex interactions with multiple scene surfaces of different material types before being reflected towards a detector. During this transport, every surface reflection and propagation is encoded in the properties of the photons that ultimately reach the detector, including travel time, direction, intensity, wavelength and polarization. Conventional imaging systems capture intensity by integrating over all other dimensions of the incident light into a single quantity, hiding this rich scene information in these aggregate measurements. Existing methods are capable of untangling these measurements into their spatial and temporal dimensions, fueling geometric scene understanding tasks. However, examining polarimetric material properties jointly with geometric properties is an open challenge that could enable unprecedented capabilities beyond geometric scene understanding, allowing for material-dependent scene understanding and imaging through complex transport, such as macroscopic scattering.In this work, we close this gap, and propose a computational light transport imaging method that captures the spatially- and temporally-resolved complete polarimetric response of a scene, which encodes rich material properties. Our method hinges on a novel 7D tensor theory of light transport. We discover low-rank structure in the polarimetric tensor dimension and propose a data-driven rotating ellipsometry method that learns to exploit redundancy of polarimetric structure. We instantiate our theory with two imaging prototypes: spatio-polarimetric imaging and coaxial temporal-polarimetric imaging. This allows us, for the first time, to decompose scene light transport into temporal, spatial, and complete polarimetric dimensions that unveil scene properties hidden to conventional methods. We validate the applicability of our method on diverse tasks, including shape reconstruction with subsurface scattering, seeing through scattering media, untangling multi-bounce light transport, breaking metamerism with polarization, and spatio-polarimetric decomposition of crystals.
Super Enhancer-Mediated Upregulation ofHJURPPromotes Growth and Survival of t(4;14)-Positive Multiple Myeloma
Authors: Jia Yunlu , Zhou Jianbiao , Tan Tze King , Chung Tae-Hoon , Chen Yongxia , Chooi Jing-Yuan , Sanda Takaomi , Fullwood Melissa J. , Xiong Sinan , Toh Sabrina H.M. , Balan Kalpnaa , Wong Regina W.J. , Lim Julia S.L. , Zhang Enfan , Cai Zhen , Shen Peng , Chng Wee Joo 
Published: December 2021

AbstractMultiple myeloma is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnormality t(4;14) (p16.3;q32.3) confers aggressive behavior in multiple myeloma. Recently, essential oncogenic drivers in a wide range of cancers have been shown to be controlled by super-enhancers (SE). We used chromatin immunoprecipitation sequencing of the active enhancer marker histone H3 lysine 27 acetylation (H3K27ac) to profile unique SEs in t(4;14)-translocated multiple myeloma. The histone chaperone HJURP was aberrantly overexpressed in t(4;14)-positive multiple myeloma due to transcriptional activation by a distal SE induced by the histone lysine methyltransferase NSD2. Silencing of HJURP with short hairpin RNA or CRISPR interference of SE function impaired cell viability and led to apoptosis. Conversely, HJURP overexpression promoted cell proliferation and abrogated apoptosis. Mechanistically, the NSD2/BRD4 complex positively coregulated HJURP transcription by binding the promoter and active elements of its SE. In summary, this study introduces SE profiling as an efficient approach to identify new targets and understand molecular pathogenesis in specific subtypes of cancer. Moreover, HJURP could be a valuable therapeutic target in patients with t(4;14)-positive myeloma.Significance:A super-enhancer screen in t(4;14) multiple myeloma serves to identify genes that promote growth and survival of myeloma cells, which may be evaluated in future studies as therapeutic targets.
Association of Region‐Specific Cardiac Adiposity With Dysglycemia and New‐Onset Diabetes
Authors: Sung Kuo‐Tzu , Kuo Jen‐Yuan , Yun Chun‐Ho , Lin Yueh‐Hung , Tsai Jui‐Peng , Lo Chi‐In , Hsiao Chih‐Chung , Lai Yau‐Huei , Tsai Cheng‐Ting , Hou Charles Jia‐Yin , Su Cheng‐Huang , Yeh Hung‐I , Chien Chen‐Yen , Hung Ta‐Chuan , Hung Chung‐Lieh 
Published: December 2021

Background
Visceral adipose tissue is assumed to be an important indicator for insulin resistance and diabetes beyond overweight/obesity. We hypothesized that region‐specific visceral adipose tissue may regulate differential biological effects for new‐onset diabetes regardless of overall obesity.

Methods and Results

We quantified various visceral adipose tissue measures, including epicardial adipose tissue, paracardial adipose tissue, interatrial fat, periaortic fat, and thoracic aortic adipose tissue in 1039 consecutive asymptomatic participants who underwent multidetector computed tomography. We explored the associations of visceral adipose tissue with baseline dysglycemic indices and new‐onset diabetes. Epicardial adipose tissue, paracardial adipose tissue, interatrial fat, periaortic fat, and thoracic aortic adipose tissue were differentially and independently associated with dysglycemic indices (fasting glucose, postprandial glucose, HbA1c, and homeostasis model assessment of insulin resistance) beyond anthropometric measures. The superimposition of interatrial fat and thoracic aortic adipose tissue on age, sex, body mass index, and baseline homeostasis model assessment of insulin resistance expanded the likelihood of baseline diabetes (from 67.2 to 86.0 and 64.4 to 70.8,
P
for ∆ ꭕ
2
: <0.001 and 0.011, respectively). Compared with the first tertile, the highest interatrial fat tertile showed a nearly doubled risk for new‐onset diabetes (hazard ratio, 2.09 [95% CI, 1.38–3.15],
P
<0.001) after adjusting for Chinese Visceral Adiposity Index.

Conclusions
Region‐specific visceral adiposity may not perform equally in discriminating baseline dysglycemia or diabetes, and showed differential predictive performance in new‐onset diabetes. Our data suggested that interatrial fat may serve as a potential marker for new‐onset diabetes.
From Stone to Dust: The Life of the Kufic-Inscribed Frieze of Wuqro Cherqos in Tigray, Ethiopia
Authors: Muehlbauer Mikael 
Published: December 2021

Abstract
Until 2010 (when it was broken by a tourist), a curious Kufic-inscribed sandstone block greeted those who entered the narthex of the eleventh-century church of Wuqro Cherqos in East Tigray, Ethiopia. My paper identifies the origin of this misunderstood fragment and presents it in the longue durée, from its architectural placement as part of an inscribed arch in the great mosque of a Fatimid trading colony to its medieval spoliation and use as a chancel arch in the church of Wuqro Cherqos, after northern Ethiopia emerged as a centralized power under the Zagwe dynasty. As the chancel in Wuqro Cherqos, the stone took on new meaning as a luxurious liturgical threshold, complementing the Egyptian and Indian silks that hung alongside it. After the arch came apart in the late 1990s, I show how modern Ethiopian scholars promoted the remaining Arabic-inscribed fragment as an ancient Ethiopian inscription. The life story of this stone fragment reveals a larger picture of Islam’s changing reception in Ethiopia from the Middle Ages to the twenty-first century.
A History of the Ottoman Fez before Mahmud II (ca. 1600–1800)
Authors: Ben Ismail Youssef 
Published: December 2021

Abstract
The history of the Ottoman fez is usually told with the nineteenth century as a point of departure. In the 1820s and 1830s, the reforms initiated by Sultan Mahmud II (r. 1808–39) elevated the red felt cap to the rank of official headgear of the Ottoman empire. But little is known about its history prior to its adoption by the state: where did the fez come from and how did it become so prevalent in the Ottoman empire? This essay examines the global history of the fez in the seventeenth and eighteenth centuries. Taking Mahmud II’s reforms as an endpoint, it examines the process by which the headgear first came to be both culturally visible and commercially available in the Ottoman realm. Three aspects of this history are considered: the trans-imperial history of the fez as a commercial commodity, its cultural reception in the Ottoman world, and the establishment of a community of Tunisian fez merchants in early modern Istanbul.
Colonial Zaytuna: The Making of a Minaret in French-Occupied Tunisia
Authors: Lamine Sihem 
Published: December 2021

Abstract
In March 1892, eleven years after the establishment of the French protectorate in Tunisia, a congregation of ulemas, religious scholars, and students, as well as representatives of the waqf administration (Jamʿiyyat al-Awqāf) gathered in the ṣaḥn of the Zaytuna Mosque to lay the cornerstone of a new minaret. The pre-exiting tower, whose latest major renovations dated from the seventeenth-century Ottoman Muradid times, was deemed hazardous; it was therefore entirely demolished and replaced by a large-scale replica of the nearby Hafsid Kasbah Mosque of Tunis. The new minaret of the Zaytuna Mosque rose in tandem with the Saint Vincent de Paul Cathedral of Tunis, and simultaneously with the nascent French neighborhoods of Tunis outside and along the medina walls. This article explores the intricate and fascinating context of the construction of a monumental minaret in a city that was gradually severing ties with its Ottoman past and surrendering to a newly established colonial rule. It questions the role and aspirations of the French administration in the minaret project, the reasons that led to the revival of the Almohad architectural style in the late nineteenth-century Maghrib, and the legacy left by the re-appropriation of this style in North Africa.
New Data on the Luster Tiles of ʿAbd al-Samad’s Shrine in Natanz, Iran
Authors: Leone Anaïs 
Published: December 2021

Abstract
This essay offers new data for identifying and reconstructing the original luster tilework decoration of the tomb chamber of the ʿAbd al-Samad shrine in Natanz, central Iran. The decorated complex around the tomb was likely built during the Ilkhanid period. The removal of Ilkhanid-period luster tiles from their original location has left very few buildings with their original decoration. Moreover, the stripping of an important number of monuments led to the arrival of thousands of tiles of unidentified or incomplete provenance in public and private collections. By cross-referencing available information about preserved revetments (e.g., dimensions, inscriptions, provenance, designs) with verifiable data collected at surviving monuments, it is possible to bridge the gap and unite formerly isolated elements. This study formulates new proposals about the luster tilework in the shrine of ʿAbd al-Samad, especially with regard to the complex ensemble of the mihrab. By locating and detailing the different zones of its decorative scheme, the ensemble becomes more coherent as a whole despite its remaining gaps.
Pre-service Physics Teachers’ Beliefs about Learning Physics and Their Learning Achievement in Physics
Authors: Kim Hong-Jeong , Im Sungmin 
Published: December 2021

Abstract
This study investigates pre-service teachers’ beliefs about learning physics and explores how beliefs correlate with learning achievement as evidenced by conceptual understanding and grades in a year-long physics course. To investigate beliefs about learning physics, 14 second-year pre-service teachers in a teacher training program in South Korea completed a Likert-style questionnaire called the Beliefs About Learning Physics Survey (BAPS). To measure learning achievement, final grades for the physic course were obtained and the Force Concept Inventory (FCI) was used to assess conceptual understanding. Analysis revealed that pre-service physics teachers’ beliefs about learning physics had a positive correlation with conceptual understanding but not with motivational beliefs. Students’ grades in physics had a positive correlation with cognitive beliefs, regardless of changes in pre- and post-test responses. Implications about how to utilize pre-service physics teachers’ beliefs about learning physics as an epistemological resource for teaching and learning physics are discussed.
Effective interventions within the scope of occupational therapy practice to address participation for adults with aphasia: A systematic review
Authors: Escher Anne A , McKinnon Sarah , Berger Sue 
Published: December 2021

Introduction Occupational therapists work with clients with impaired communication to re-engage in valued occupations. This systematic review seeks to answer the question: What are effective interventions within the scope of occupational therapy practice to address participation for adults with aphasia? Method A systematic review of the literature was completed using PubMed, PsychInfo, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, Cochrane Database of Systematic Reviews, and OT Seeker databases. Intervention studies within the scope of occupational therapy practice with a participation outcome, and published in peer reviewed journals from 2000 to 2019, were included. The quality of each study was assessed using the Mixed Methods Appraisal Tool. Findings Thirteen articles fit the inclusion criteria. Categories of interventions that emerged from the data include community-based groups, individually tailored programs, adaptation/presentation of materials, interprofessional interventions, and psychoeducation. Conclusion There is evidence to support the use of interventions within the scope of occupational therapy practice to increase participation for people with aphasia. Specifically, the use of community-based groups and adaptation of materials are effective to facilitate participation. Most of the studies were pre-post one group design; however, they demonstrated positive results for participation outcomes. More research is needed on people with aphasia that focuses on participation in meaningful occupations.
Avoiding material hardship: The buffer function of wealth
Authors: Rodems Richard , Pfeffer Fabian T 
Published: December 2021

We assess how a variety of disruptive life-course events impact the economic wellbeing of US households and trace the importance of household wealth in helping families who experience these events avoid entering a spell of material hardship. Using longitudinal data from two panels of the Survey of Income and Program Participation (SIPP), we draw on direct measures of material hardship, disruptive events and household assets. Our analyses reveal that the relationship between disruptive events and the likelihood of experiencing a new spell of material hardship strongly varies across the wealth distribution, suggesting that high household wealth provides an effective private safety net. By distinguishing different types of disruptive events, we demonstrate that divorce, disability and income loss entail a risk of material hardship but also that this risk is effectively buffered by substantial wealth. Different types of hardship – namely, financial, food and medical hardship – respond in similar ways. Like public insurance schemes, wealth insurance helps buffer the effects of disruptive events on material hardship, but unlike public insurance schemes, reliance on private wealth further stratifies the economic wellbeing of households. Policy options for addressing this highly stratified private insurance scheme include disposing of the need for it by funding more robust public insurance, for instance through wealth taxation.
Changes in Sleep Quality Following Treatment for Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Authors: Fried Jacob , Yuen Erick , Gudis David A. , Schlosser Rodney J. , Nguyen Shaun A. , Rowan Nicholas R. 
Published: December 2021

Background Chronic rhinosinusitis (CRS) presents with broad and systemic manifestations, including impaired sleep; however, the impact of CRS treatments upon sleep is unknown. Objective To establish the effect of medical or surgical CRS treatment on subjective and objective sleep metrics for patients not previously diagnosed with sleep apnea. Methods Review of PubMed, Scopus, Web of Science, and the Cochrane Library was performed from the databases’ date of inception through August 13, 2020, for studies evaluating the effect of CRS treatment on sleep quality. All studies reporting on subjective and objective sleep parameters for patients with CRS, with completed pre- and posttreatment data were included. Studies composed of patients with diagnosed sleep apnea were excluded. Results Sixteen unique studies reporting data on a total of 1770 patients (mean age, 50.6 ± 15.6 (n = 1675) years) following treatment for CRS were included. Patient-reported outcome measures, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Fatigue Severity Scale, demonstrated mean posttreatment differences of −2.8 (95% CI: −4.9 to −0.7), −2.4 (95% CI: −3.7 to −1.2), and −1.2 (95% CI: −1.6 to −0.7), respectively. The SNOT-22 and its sleep domain demonstrated a mean posttreatment difference of −23.5 (95% CI: −31.7 to −15.3) and −5.4 (95% CI: −6.8 to −4.0), respectively. EpSS, FSS and SNOT-22 exceeded their respective reported MCID values. Objective findings did not significantly change with treatment; mean difference: AHI: 0.7 (95% CI: −1.5 to 2.9), oxygen nadir: 0.3 (95% CI: −0.4 to 0.9). Conclusions Treatment of CRS may lead to clinically meaningful reduction in disease burden and improvements in both overall sleep quality and patient-reported fatigue. Despite clinically meaningful quality of life improvements, objective sleep parameters did not demonstrate corresponding posttreatment improvements.
Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis
Authors: Marar Tanya T. , Matzko Chelsea N. , Wu Jie , Esmon Charles T. , Sinno Talid , Brass Lawrence F. , Stalker Timothy J. , Tomaiuolo Maurizio 
Published: December 2021

Abstract
Rebalancing the hemostatic system by targeting endogenous anticoagulant pathways, like the protein C (PC) system, is being tested as a means of improving hemostasis in patients with hemophilia. Recent intravital studies of hemostasis demonstrated that, in some vascular contexts, thrombin activity is sequestered in the extravascular compartment. These findings raise important questions about the context-dependent contribution of activated PC (APC) to the hemostatic response, because PC activation occurs on the surface of endothelial cells. We used a combination of pharmacologic, genetic, imaging, and computational approaches to examine the relationships among thrombin spatial distribution, PC activation, and APC anticoagulant function. We found that inhibition of APC activity, in mice either harboring the factor V Leiden mutation or infused with an APC-blocking antibody, significantly enhanced fibrin formation and platelet activation in a microvascular injury model, consistent with the role of APC as an anticoagulant. In contrast, inhibition of APC activity had no effect on hemostasis after penetrating injury of the mouse jugular vein. Computational studies showed that differences in blood velocity, injury size, and vessel geometry determine the localization of thrombin generation and, consequently, the extent of PC activation. Computational predictions were tested in vivo and showed that when thrombin generation occurred intravascularly, without penetration of the vessel wall, inhibition of APC significantly increased fibrin formation in the jugular vein. Together, these studies show the importance of thrombin spatial distribution in determining PC activation during hemostasis and thrombosis.
Treatment of older adult or frail patients with multiple myeloma
Authors: Grant Shakira J. , Freeman Ciara L. , Rosko Ashley E. 
Published: December 2021

Abstract
Older adults with multiple myeloma (MM) are a growing population, and personalizing treatment based on disease and health status is imperative. Similar to MM staging systems that provide disease-related prognostic information, myeloma-specific frailty tools can better identify subgroups at greatest risk for treatment-related toxicity and early treatment discontinuation, as well as predict overall survival. Several myeloma-specific validated tools are well studied. Although these fitness/frailty scores have shaped our understanding of the heterogeneity among older adults with myeloma, the application of such scores in treatment decision making (ie, transplant considerations, relapse) is an unmet need. Here we outline how to incorporate frailty assessments in the evaluation of older adults with MM in the clinical setting with consideration of other factors such as patient preferences, treatment risks/benefits, life expectancy, and disease biology.
Cryptogenic oozers and bruisers
Authors: Smock Kristi J. , Moser Karen A. 
Published: December 2021

AbstractBleeding disorders with normal, borderline, or nondiagnostic coagulation tests represent a diagnostic challenge. Disorders of primary hemostasis can be further evaluated by additional platelet function testing modalities, platelet electron microscopy, repeat von Willebrand disease testing, and specialized von Willebrand factor testing beyond the usual initial panel. Secondary hemostasis is further evaluated by coagulation factor assays, and factor XIII assays are used to diagnose disorders of fibrin clot stabilization. Fibrinolytic disorders are particularly difficult to diagnose with current testing options. A significant number of patients remain unclassified after thorough testing; most unclassified patients have a clinically mild bleeding phenotype, and many may have undiagnosed platelet function disorders. High-throughput genetic testing using large gene panels for bleeding disorders may allow diagnosis of a larger number of these patients in the future, but more study is needed. A logical laboratory workup in the context of the clinical setting and with a high level of expertise regarding test interpretation and limitations facilitates a diagnosis for as many patients as possible.
Blast and accelerated phase CML: room for improvement
Authors: How Joan , Venkataraman Vinayak , Hobbs Gabriela Soriano 
Published: December 2021

Abstract
Tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic myeloid leukemia (CML). With TKI therapy, the percentage of patients who progress to accelerated phase (AP) or blast phase (BP) CML has decreased from more than 20% to 1% to 1.5% per year. Although AP- and BP-CML occur in a minority of patients, outcomes in these patients are significantly worse compared with chronic phase CML, with decreased response rates and duration of response to TKI. Despite this, TKIs have improved outcomes in advanced phase CML, particularly in de novo AP patients, but are often inadequate for lasting remissions. The goal of initial therapy in advanced CML is a return to a chronic phase followed by consideration for bone marrow transplantation. The addition of induction chemotherapy with TKI is often necessary for achievement of a second chronic phase. Given the small population of patients with advanced CML, development of novel treatment strategies and investigational agents is challenging, although clinical trial participation is encouraged in AP and BP patients, whenever possible. We review the overall management approach to advanced CML, including TKI selection, combination therapy, consideration of transplant, and novel agents.