bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic therapies in advanced epithelioid haemangioendothelioma: A retrospective international case series from the World Sarcoma Network and a review of literature
Authors: Frezza Anna M. , Ravi Vinod , Lo Vullo Salvatore , Vincenzi Bruno , Tolomeo Francesco , Chen Tom Wei‐Wu , Teterycz Pawel , Baldi Giacomo G. , Italiano Antoine , Penel Nicolas , Brunello Antonella , Duffaud Florance , Hindi Nadia , Iwata Shintaro , Smrke Alannah , Fedenko Alexander , Gelderblom Hans , Van Der Graaf Winette , Vozy Aurore , Connolly Elizabeth , Grassi Massimiliano , Benjamin Robert S. , Broto Javier‐Martin , Grignani Giovanni , Jones Robin L. , Kawai Akira , Tysarowski Andrzej , Mariani Luigi , Casali Paolo G. , Stacchiotti Silvia 
Published: March 2021

AbstractBackgroundThis observational, retrospective effort across Europe, US, Australia, and Asia aimed to assess the activity of systemic therapies in EHE, an ultra‐rare sarcoma, marked by WWTR1‐CAMTA1 or YAP1‐TFE3 fusions.MethodsTwenty sarcoma reference centres contributed data. Patients with advanced EHE diagnosed from 2000 onwards and treated with systemic therapies, were selected. Local pathologic review and molecular confirmation were required. Radiological response was retrospectively assessed by local investigators according to RECIST. Progression free survival (PFS) and overall survival (OS) were estimated by Kaplan‐Meier method.ResultsOverall, 73 patients were included; 21 had more than one treatment. Thirty‐three patients received anthracyclines regimens, achieving 1 (3%) partial response (PR), 25 (76%) stable disease (SD), 7 (21%) progressive disease (PD). The median (m‐) PFS and m‐OS were 5.5 and 14.3 months respectively. Eleven patients received paclitaxel, achieving 1 (9%) PR, 6 (55%) SD, 4 (36%) PD. The m‐PFS and m‐OS were 2.9 and 18.6 months, respectively. Twelve patients received pazopanib, achieving 3 (25%) SD, 9 (75%) PD. The m‐PFS and m‐OS were.2.9 and 8.5 months, respectively. Fifteen patients received INF‐α 2b, achieving 1 (7%) PR, 11 (73%) SD, 3 (20%) PD. The m‐PFS and m‐OS were 8.9 months and 64.3, respectively. Among 27 patients treated with other regimens, 1 PR (ifosfamide) and 9 SD (5 gemcitabine +docetaxel, 2 oral cyclophosphamide, 2 others) were reported.ConclusionSystemic therapies available for advanced sarcomas have limited activity in EHE. The identification of new active compounds, especially for rapidly progressive cases, is acutely needed.
Exploring the experiences of non‐statutory homeless individuals who engaged in an adventure therapy intervention
Authors: Shehade Orla , Kyriakopoulos Alex 
Published: March 2021

AbstractIt has been suggested that homeless people might struggle with access to accommodation and health services and experience poor mental health. Although housing support is suggested to be the most important service provision, it has been recommended that integrated approaches, incorporating both housing and psychosocial support, are required. Nevertheless, there is limited research exploring therapeutic interventions for homeless people. This study focuses on experiences of individuals experiencing “non‐statutory” homelessness with self‐reported mental health difficulties who were living in supported hostel accommodation and had engaged in an adventure therapy intervention. Semi‐structured interviews with the use of repertory‐grid technique were carried out with seven participants. Transcripts were analysed using interpretative phenomenological analysis. Three master themes were identified: (a) respite from negative experiences of homelessness; (b) empowerment in relation to developing a sense of purpose and increased perceived self‐efficacy; and (c) changed worldviews in relation to themselves and others. Participants reported development of a community, which provided a holding environment to meet their expressed support and psychological healthcare needs. The psychological implications of this study point towards therapeutic interventions, which involve meaningful activities, encourage contact with the natural environment, provide a space of emotional containment and develop a sense of community as a means of improving sense of well‐being.
Mindfulness as practice: A network analysis of FMI data
Authors: Smith Joseph H. , Kempton Heather M. , Williams Matt N. , van Ommen Clifford 
Published: March 2021

AbstractMindfulness research implicitly conceives of mindfulness as an identifiable real ‘thing’ that exists beyond what is directly observed. Recently, a new methodology has been developed which allows mindfulness to be modelled as a complex system or network at the level of self‐report. In these models, items become a network's nodes, and the statistical relations between them, edges. Interpreted causally, nodes are thought to increasingly influence each other via their edges, such that they become increasingly correlated. This study hypothesises that at a cross‐sectional level, this may result in differences in overall network connectivity (density) between practitioners and non‐practitioners.Mindfulness networks were estimated for practitioners and non‐practitioners using the Friedberg Mindfulness Inventory (FMI). A total of 371 regular mindfulness practitioners and 283 non‐practitioners (including 59 irregular practitioners) were recruited online from Amazon Mechanical Turk.Comparisons of practitioners’ and non‐practitioners’ networks indicated that network density did not significantly differ, whereas evidence was found in support of a significant difference in network structure. An exploratory analysis revealed substantive group differences in how items (practices) were connected. In particular, the practice of Acceptance appeared more central to the practitioners’ network relative to the non‐practitioners' network, indicating Acceptance may be particularly useful for engagement in mindfulness practices.The study supports investigating mindfulness as a complex network at the level of self‐report, with implications for how the development of mindfulness is conceptualised. The lack of difference in network density indicates that research is needed to examine network dynamics in the context of regular mindfulness practice.
Therapists' perspectives on working with clients taking psychiatric drugs: Findings from a mixed‐methods survey
Authors: Blair Lewis , Heydon‐Hatchett Victoria , Davies Gabriel , Guy Anne , Davies James 
Published: March 2021

AbstractObjectivesAround 26% of the British adult population are prescribed psychiatric drugs each year. Most therapists (counsellors, psychotherapists and psychologists) provide therapy to some clients taking prescribed psychiatric drugs. This study aimed to better understand the experience, knowledge, training and concerns of therapists working therapeutically with clients prescribed psychiatric drugs.DesignThis was a survey study, generating both quantitative and qualitative data.MethodsThe online survey was completed by 1,230 therapists (members of UKCP, BACP and the BPS). Brief descriptive statistics for the quantitative data are reported. The qualitative data were analysed thematically.ResultsTherapists would welcome professional guidance as to how to work better with clients taking prescribed psychiatric drugs, with some feeling their training had left them unprepared for this. Qualitative themes were broad‐ranging and encompassed the following: client factors, therapist factors, prescriber actions and inactions, medicating therapy, the ideological and professional context, areas of therapist need, and actions and justifications that mitigate concerns.ConclusionsThis article illustrates the complex nature of therapeutic work with clients taking, or withdrawing from, prescribed psychiatric drugs. Therapists want to work within their remit to appropriately help clients but need better information and improved relationships with prescribing clinicians.
The software will see you now: The promise and peril of digital therapy
Authors: Quill Lawrence 
Published: March 2021

AbstractThe response to the COVID‐19 pandemic has prompted discussion across a range of fields and disciplines as numerous professions embrace an online or virtual environment. This paper focuses upon the provision of therapy in a digital environment specifically through the development of Mental Health Apps (mHealth). The latter are seen as a remedy to the lack of qualified therapists providing mental health services to populations who lack access to adequate and affordable mental health care. Within this context, this paper draws attention to the central value of dignity. Dignity lies at the heart of the therapeutic encounter and the profession more broadly. I consider some of the challenges posed to dignity both philosophically and from the perspective of technologists. These challenges pose an acute dilemma for therapists who find themselves providing a ‘service’ that is increasingly driven by demands for greater efficiency and a digital environment that offers therapy on demand. I place the perceived ‘crisis of mental health’ in context and suggest that some form of regulation is required for digital therapy apps if trained therapists are to continue to offer a professional service while clients are protected from exploitative practices.
Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Novel Indolylacrylamide Derivatives: Synthesis and Biological Evaluation
Authors: Hawash Mohammed , Kahraman Deniz Cansen , Cetin‐Atalay Rengul , Baytas Sultan Nacak 
Published: March 2021

AbstractHepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and one of the leading causes of cancer associated death worldwide. This is due to the highly resistant nature of this malignancy and the lack of effective treatment options for advanced stage HCC patients. The hyperactivity of PI3K/Akt and Ras/Raf/MEK/ERK signaling pathways contribute to the cancer progression, survival, motility, and resistance mechanisms, and the interaction of these two pathways are responsible for the regulation of cancer cell growth and development. Therefore, it is vital to design and develop novel therapeutic options for HCC treatment targeting these hyperactive pathways. For this purpose, novel series of trans‐indole‐3‐ylacrylamide derivatives originated from the lead compound, 3‐(1H‐indole‐3‐yl)‐N‐(3,4,5‐trimethoxyphenyl)acrylamide, have been synthesized and analyzed for their bioactivity on cancer cells along with the lead compound. Based on the initial screening, the most potent compounds were selected to elucidate their effects on cellular signaling activity of HCC cell lines. Cell cycle analysis, immunofluorescence, and Western blot analysis revealed that lead compound and (E)‐N‐(4‐tert‐butylphenyl)‐3‐(1H‐indole‐3‐yl)acrylamide induced cell cycle arrest at the G2/M phase, enhanced chromatin condensation and PARP‐cleavage, addressing induction of apoptotic cell death. Additionally, these compounds decreased the activity of ERK signaling pathway, where phosphorylated ERK1/2 and c‐Jun protein levels diminished significantly. Relevant to these findings, the lead compound was able to inhibit tubulin polymerization as well. To conclude, the novel trans‐indole‐3‐ylacrylamide derivatives inhibit one of the critical pathways associated with HCC which results in cell cycle arrest and apoptosis in HCC cell lines.
COVID‐19, when fourteen days are not enough—A case series of affected healthcare workers
Authors: Murphy Catherine , Noonan Noirin , O’Toole Eilis , Plunkett Patrick , Paula Colgan Mary , Canning Caitriona , Martin Zenia , Hennessy Martina 
Published: March 2021

AbstractWe highlight the need for planning for mass workforce absentees as we prepare for subsequent surges. We suggest a multicomponent intervention including guiding return dates more by symptomatology and fitness for work rather than infectivity status.
Rectal ulcer in a hemodialysis patient receiving Kayexalate®
Authors: Collot Julia , Salaouatchi Tayeb , Rickaert Fabienne , Floriani Albino , Buysschaert Benoit , Mesquita Maria , Godon Eric 
Published: March 2021

AbstractKayexalate can cause severe unrecognized GI lesions. Diagnosis of kayexalate crystals in GI biopsy samples is important. Pathologists and clinicians should work hand in hand. New drugs should be available to all patients to treat hyperkalemia.
Zeolite‐Supported Rhenium Catalysts for the Deoxydehydration of 1,2‐Hexanediol to 1‐Hexene
Authors: Meiners Isabell , Louven Yannik , Palkovits Regina 
Published: March 2021

AbstractFor the first time ammonium perrhenate (APR) supported on zeolites of the types H‐β, H‐ZSM‐5 and H−Y were shown to be efficient catalysts for the deoxydehydration (DODH). They catalyzed the transformation of 1,2‐hexanediol (1,2‐HDO) to 1‐hexene in the presence of 3‐octanol as reductant and solvent with productivities up to 0.24 mol1‐hexene ⋅ gRe−1 ⋅ h−1. The productivity decreased with increasing Si : Al ratio, independent of the zeolite structure. Catalyst characterization indicates Re‐species to preferably bind to the Al centers of the support, resulting in a higher amount of active metal centers.
Enhanced Electrochemiluminescence in a Microwell Bipolar Electrode Array Prepared with an Optical Fiber Bundle
Authors: Li Haidong , Zhang Tian , Zhou Han , Zhang Zhicheng , Liu Miaoxia , Wang Chengyin 
Published: March 2021

AbstractThe creation of microwells on an electrode surface has been used to improve the electrode performance. Herein, we report the fabrication of a microwell bipolar electrode array (MBEA) by selectively etching a fiber core and coating a thin gold layer on one pole of optical fiber bundle. The remote electrochemiluminescence (ECL) sensing platform is developed with the combination of the MBEA and ECL, such that light emission is generated at the distal face of the optical fiber bundle and detected at its proximal face. The resulting microwells in the MBEA can enhance the ECL generation, and produce a bell‐like ECL emission, for which higher light intensity is measured in the center of the fiber core than around its periphery. Then, it is revealed in theoretical simulations that the parabolic‐shaped bottom in the microwell induces the strong overlapped diffusion fields in its center and promotes the generation of ECL there. Finally, the application of MBEA is demonstrated in the detection of nicotinamide adenine dinucleotide (NADH).
A common theme for axonopathies? The dependency cycle of local axon homeostasis
Authors: Prokop Andreas 
Published: March 2021

AbstractThe number of acquired or inherited conditions leading to axon degeneration (from now on referred to as axonopathies) is vast. To diagnose patients, clinicians use a range of indicators including physiology, morphology, family and patient history, as well as genetics, with the specific location of the lesion within the nervous system being a prominent feature. For the neurobiologist, these criteria are often unsatisfactory, and key questions remain unanswered. For example, does it make sense that different axonopathies affect distinct neuron groups through distinct mechanisms? Would it not be more likely that there are common routes to axon degeneration? In this opinion piece, I shall pose this fundamental question and try to find answers that are hopefully thought‐provoking and trigger some conceptual rethinking in the field. I will conclude by describing the ‘dependency cycle of axon homeostasis’ as a new approach to make sense of the intricate connections of axon biology and physiology, also suggesting that different axonopathies might share common paths to axon degeneration.
Observer variability study and method to implement observer categories for novel light source projection system
Authors: Bai Chris Yi‐Ho , Ou Li‐Chen 
Published: March 2021

AbstractAs display technology advances in color gamut, the potential of experiencing higher degree of observer metamerism is more likely with narrow bandwidth stimuli display devices. In previous studies, it is confirmed that observer metamerism was introduced in soft proofing with monitor and color grading with projector scenarios, and also led to serious implications. Hence, it is desired to investigate whether laser‐based projection system would introduce observer metamerism compared to halogen‐based projection system. In this study, a two‐part experiment was designed and conducted. Experiment 1 was based on color patches and experiment 2 was based on test images. Intra‐observer and inter‐observer variability were calculated and analyzed. Both experiments had illustrated observer metamerism was introduced in laser‐based projection system. Comparison to CIE Standard Observers was also conducted for each experiment, and the results had suggested that the CIE Standard Observers were not suitable for laser‐based projection system. A new observer category was required at least for the group of observers participating the experiments. A quick method to transform the content from the CIE 1964 Standard Observer for color patches or the CIE 1931 Standard Observer for images has been established in experiment 1, and this quick method could help to facilitate the growth of personalized color management system.
Computational evidence of first extensive usage of violet in the 1860s
Authors: Tager Allen , Kirchner Eric , Fedorovskaya Elena 
Published: March 2021

AbstractTager showed that works of art rarely contained the color violet until the Impressionists in the mid‐19th century. This article further investigates the prevalence of different colors in paintings. We analyzed 4117 Western and Eastern paintings, extending Tager's previous research. Combining color science, image analysis algorithms, and new research on color categorization, we were able to calculate the frequencies of occurrence of several different color categories in digital images of paintings from several major art museums. Our analysis shows how the frequency of use of the various color categories vary between different cultural periods and regions. The color violet was shown to have a substantial presence on only 2% to 4% of the artworks created before the early 1860s. It quickly became very popular soon after that date, rising to a substantial presence of 36.5% to 47.9%. Textual analyses indicate a similar trend in the popularity of the color term violet. We discuss several explanations for the steep increase in the use of violet in paintings in the early 1860s. Neither cultural factors with roots in ancient Greece, nor the introduction of cheap purple and so‐called violet pigments in the 1860s, can sufficiently explain the trends that we found. An increased sensitivity to violet colors due to continuous evolution of the human visual system offers an alternative explanation. We finally show that contemporary developments in color theory and their adoption by Impressionist painters may almost naturally have led to an increase in the use of violet from 1863 onwards.
Secure decision tree twin support vector machine training and classification process for encrypted IoT data via blockchain platform
Authors: Dey Prasanjit , Chaulya Swades Kumar , Kumar Sanjay 
Published: March 2021

SummaryA secure decision tree twin support vector machine (DT‐TSVM) multi‐classification algorithm has been proposed in this paper for improving the reliability and security of the collected IoT data from multiple data providers. The multiclass secure DT‐TSVM algorithm has been employed to train a machine learning model using the encrypted training dataset. The training dataset is collected via a blockchain platform. A blockchain method has been adopted to construct a secure and reliable distributed platform among dataset providers. The Paillier homomorphic cryptosystem has been applied for encrypting the IoT dataset. Then, the dataset has been recorded on the distributed ledger. The secure DT‐TSVM algorithm's‐based train model effectiveness has been compared with the other two available algorithms, namely the multiclass binary support vector machine (MBSVM) and one‐to‐one SVM algorithms. The experiment results showed that the privacy‐preserving multiclass secure DT‐TSVM‐based model did not reduce the accuracy, but it increased the average precision and recall by 0.53% and 0.44% than MBSVM and 0.82% and 0.71% than one‐to‐one SVM, respectively. Further, the time consumption of data providers and data analysts did not change significantly with the increase of number of data provider.
Tracking Charge Accumulation in a Functional Triazole‐Linked Ruthenium‐Rhenium Dyad Towards Photocatalytic Carbon Dioxide Reduction
Authors: Gotico Philipp , Tran Thu‐Trang , Baron Aurelie , Vauzeilles Boris , Lefumeux Christophe , Ha‐Thi Minh‐Huong , Pino Thomas , Halime Zakaria , Quaranta Annamaria , Leibl Winfried , Aukauloo Ally 
Published: March 2021

AbstractThe [Re(bpy)(CO)3Cl] catalyst pioneered by Lehn for the two‐electron reduction of CO2 has constantly revealed unique facets in the mechanistic understanding of the selective transformation of CO2. A novel triazole‐linked ruthenium photosensitizer and a rhenium catalyst dyad was synthesized and investigated for photo‐induced charge accumulation using time‐resolved absorption spectroscopy. The triazole bridging ligand promoted weak electronic communication between the two units, resulting in an anodic shift of the reduction potentials of the Re moiety. Upon excitation of the photosensitizer, the first reduction of the catalyst occurred with a fast apparent rate of >5×107 s−1. Using a double‐excitation nanosecond pump‐pump‐probe setup to track the second electron accumulation on the catalytic unit was not conclusive as no observable absorption changes occurred upon the second excitation, suggesting a pathway for an efficient intramolecular reverse electron transfer preventing the two‐electron accumulation at the catalyst under our experimental conditions. Nevertheless, under continuous irradiation and with the use of sacrificial electron donors, photocatalytic CO2 reduction assays showed good turnover numbers, hinting at the non‐innocent role of byproducts in solution.
Traffic load access barring scheme for random‐access channel in massive machine‐to‐machine and human‐to‐human devices coexistence in LTE‐A
Authors: Shukry Suzan , Fahmy Yasmine 
Published: March 2021

SummaryA major challenge for the development of the upcoming generations of wireless systems is to match the massive expansion of the Internet of things (IoT) applications along with the traditional human communication. Recently, 3rd Generation Partnership Project (3GPP) has suggested the use of LTE‐A to support machine‐to‐machine (M2M) communications to realize the IoT applications. One of the key concerns is the random‐access procedure in LTE‐A, the existence of a massive number of M2M devices results in system overload and congestion in the random‐access channel (RACH). In this paper, we present a new extension to the active barring‐based random‐access scheme. The proposed traffic load access barring (TLAB) RACH access scheme considers the dynamic changes in system traffic when setting the barring information. At the same time, the proposed scheme avoids unnecessary barring of some M2M devices. Our scheme improves the access delay that results from the barring of M2M devices by applying a new rule in the selection of classes to bar and classes to unbar. The simulation results show the superiority of our scheme in terms of success probability, average access delay, and average power consumption.