bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female mate preferences do not predict male sexual signals across populations
Authors: Calabrese Gina M , Pfennig Karin S 
Published: June 2021

Abstract
New species can arise when female preferences and male sexual signals diverge across populations and thereby reduce mating between populations. Under this hypothesized mechanism for speciation, mate preferences and sexual signals should be correlated, but divergent, across populations. We evaluated this prediction using spadefoot toads (Spea multiplicata). We measured a sexually selected male signal (call rate) for which female preferences are known to vary across populations in response to the risk of hybridizing with another species. Contrary to expectation, we found no correlation between male call rate and female preferences across populations. We discuss possible mechanisms of this pattern, including the effect of gene flow from heterospecifics on male call rate. Our results suggest that, even when populations vary in mating traits, the independent evolution of female preferences and male sexual signals might impede reproductive isolation between populations.
The effect of baculum shape and mating behavior on mating-induced prolactin release in female house mice
Authors: André Gonçalo I , Firman Renée C , Simmons Leigh W 
Published: June 2021

Abstract
Male genitalia are subject to rapid divergent evolution, and sexual selection is believed to be responsible for this pattern of evolutionary divergence. Genital stimulation during copulation is an essential feature of sexual reproduction. In mammals, the male intromittent genitalia induces a cascade of physiological and neurological changes in females that promote pregnancy. Previous studies of the house mouse have shown that the shape of the baculum (penis bone) influences male reproductive success and responds to experimentally imposed variation in sexual selection. Here, we test the hypothesis that the baculum is subject to sexual selection due to a stimulatory function during copulation. We selected male and female house mice (Mus musculus domesticus) from families with breeding values at the extremes of baculum shape and performed two series of experimental matings following which we examined the concentration of prolactin in the blood of females either 15 (“early”) or 75 (“late”) min after ejaculation. Our results provide evidence of a mating-induced release of prolactin in the female house mouse early after ejaculation, the level of which is dependent on an interaction between the shape of the baculum and male sexual behavior. Our data thereby provide novel insight into the mechanism(s) of sexual selection acting on the mammalian baculum.
Genetic Influence on Nociceptive Processing in the Human Brain—A Twin Study
Authors: Kastrati Gránit , Rosén Jörgen , Thompson William H , Chen Xu , Larsson Henrik , Nichols Thomas E , Tracey Irene , Fransson Peter , Åhs Fredrik , Jensen Karin B 
Published: June 2021

Abstract
Nociceptive processing in the human brain is complex and involves several brain structures and varies across individuals. Determining the structures that contribute to interindividual differences in nociceptive processing is likely to improve our understanding of why some individuals feel more pain than others. Here, we found specific parts of the cerebral response to nociception that are under genetic influence by employing a classic twin-design. We found genetic influences on nociceptive processing in the midcingulate cortex and bilateral posterior insula. In addition to brain activations, we found genetic contributions to large-scale functional connectivity (FC) during nociceptive processing. We conclude that additive genetics influence specific brain regions involved in nociceptive processing. The genetic influence on FC during nociceptive processing is not limited to core nociceptive brain regions, such as the dorsal posterior insula and somatosensory areas, but also involves cognitive and affective brain circuitry. These findings improve our understanding of human pain perception and increases chances to find new treatments for clinical pain.
COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart
Authors: Pesce Maurizio , Agostoni Piergiuseppe , Bøtker Hans-Erik , Brundel Bianca , Davidson Sean M , Caterina Raffaele De , Ferdinandy Peter , Girao Henrique , Gyöngyösi Mariann , Hulot Jean-Sebastien , Lecour Sandrine , Perrino Cinzia , Schulz Rainer , Sluijter Joost Pg , Steffens Sabine , Tancevski Ivan , Gollmann-Tepeköylü Can , Tschöpe Carsten , Linthout Sophie van , Madonna Rosalinda 
Published: June 2021

Abstract
The pandemic of coronavirus disease (COVID)-19 is a global threat, causing high mortality, especially in the elderly. The main symptoms and the primary cause of death are related to interstitial pneumonia. Viral entry also into myocardial cells mainly via the angiotensin converting enzyme type 2 (ACE2) receptor and excessive production of pro-inflammatory cytokines, however, also make the heart susceptible to injury. In addition to the immediate damage caused by the acute inflammatory response, the heart may also suffer from long-term consequences of COVID-19, potentially causing a post-pandemic increase in cardiac complications. Although the main cause of cardiac damage in COVID-19 remains coagulopathy with micro- (and to a lesser extent macro-) vascular occlusion, open questions remain about other possible modalities of cardiac dysfunction, such as direct infection of myocardial cells, effects of cytokines storm, and mechanisms related to enhanced coagulopathy. In this opinion paper, we focus on these lesser appreciated possibilities and propose experimental approaches that could provide a more comprehensive understanding of the cellular and molecular bases of cardiac injury in COVID-19 patients. We first discuss approaches to characterize cardiac damage caused by possible direct viral infection of cardiac cells, followed by formulating hypotheses on how to reproduce and investigate the hyperinflammatory and pro-thrombotic conditions observed in the heart of COVID-19 patients using experimental in vitro systems. Finally, we elaborate on strategies to discover novel pathology biomarkers using omics platforms.
A Crohn’s Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling
Authors: Goldberg Rimma , Clough Jennie N , Roberts Luke B , Sanchez Jenifer , Kordasti Shahram , Petrov Nedyalko , Hertweck Arnulf , Lorenc Anna , Jackson Ian , Tasker Scott , Appios Anna , Omer Omer , Parkes Miles , Prescott Natalie , Jenner Richard G , Irving Peter M , Lord Graham M 
Published: June 2021

Abstract

Background and Aims
Differential responsiveness to interleukin [IL]-2 between effector CD4+ T cells [Teff] and regulatory T cells [Treg] is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism [SNP] rs61839660, located within IL2RA [CD25], has been associated with the development of Crohn’s disease [CD]. We sought to identify the T cell immune phenotype of IBD patients who carry this SNP.

Methods
Teff and Treg were isolated from individuals homozygous [TT], heterozygous [CT], or wild-type [CC] for the minor allele at rs61839660, and used for phenotyping [flow cytometry, Cytometry Time Of Flight] functional assays or T cell receptor [TCR] sequencing. Phosphorylation of signal transducer and activator of transcription 5 [STAT5] was assessed in response to IL-2, IL-7, and in the presence of basiliximab, a monoclonal antibody directed against CD25. Teff pro-inflammatory cytokine expression levels were assessed by reverse transcription quantitative polymerase chain reaction after IL-2 and/or TCR stimulation.

Results
Presence of the minor T allele enhances CD25 expression, leading to increased STAT5 phosphorylation and pro-inflammatory cytokine transcript expression by Teff in response to IL-2 stimulation in vitro. Teff from TT individuals demonstrate a more activated gut homing phenotype. TCR sequencing analysis suggests that TT patients may have a reduced clonal capacity to mount an optimal regulatory T cell response.

Conclusions
rs61839660 regulates the responsiveness of T cells to IL-2 signalling by modulating CD25 expression. As low-dose IL-2 is being trialled as a selective Treg modulator in CD, these findings highlight the potential for adverse effects in patients with this genotype.
On the Judge Centredness of the International Legal Self
Authors: Zarbiyev Fuad 
Published: June 2021

Abstract
The judicial representation of international law enjoys a privileged status in international legal discourse. While this state of affairs is often acknowledged in the literature, the power of international adjudication in shaping the discipline of international law is rarely questioned. The objective of this article is to subject the status of the judicial representation of international law to a close scrutiny with a view to identifying its possible explanations and problematizing its epistemic and distributional implications.
Associations between older African academics’ physical activity, walkability and mental health: a social distancing perspective
Authors: Asiamah Nestor , Vieira Edgar Ramos , Kouveliotis Kyriakos , Gasana Janvier , Awuviry-Newton Kofi , Eduafo Richard 
Published: June 2021

Summary
This study aimed to assess the moderating influence of neighborhood walkability on the association between physical activity (PA) and mental health among older African academics aged 50 years or more in cities with social distancing protocols in response to the Coronavirus disease 2019 (COVID-19). A total of 905 volunteer academics participated in the study. A hierarchical linear regression analysis was employed to conduct sensitivity analyses and test the study hypotheses. After controlling for sex, education and age, there was a positive association between PA and mental health. Neighborhood walkability moderated the relationship between PA and mental health, which suggests that during the pandemic PA was associated with higher mental health scores in more walkable neighborhoods. The study concludes that PA was beneficial to mental health in the social distancing context and was associated with higher mental health in more walkable neighborhoods, particularly in a social distancing context.
Thermal Sensitivity of Axolotl Feeding Behaviors
Authors: Panessiti Caitlin , Rull-Garza Mateo , Rickards Gabriella , Konow Nicolai 
Published: June 2021

SynopsisMusculoskeletal movement results from muscle contractions, recoil of elastic tendons, aponeuroses, and ligaments, or combinations thereof. Muscular and elastic contributions can vary both across behaviors and with changes in temperature. Skeletal muscles reach peak contraction speed at a temperature optimum with performance declining away from that optimum by approximately 50% per 10°C, following the Q10 principle. Elastic recoil action, however, is less temperature sensitive. We subjected Axolotls (Ambystoma mexicanum) to changes from warm (23°C), via medium (14°C), to cold (6°C) temperature across most of their thermal tolerance range, and recorded jaw kinematics during feeding on crickets. We sought to determine if suction feeding strikes and food processing chews involve elastic mechanisms and, specifically, if muscular versus elastic contribution vary with temperature for gape opening and closing. Measurements of peak and mean speed for gape opening and closing during strikes and chews across temperature treatments were compared with Q10-based predictions. We found that strike gape speed decreased significantly from warm and medium to cold treatments, indicating low thermal robustness, and no performance-enhancement due to elastic recoil. For chews, peak, and mean gape closing speeds, as well as peak gape opening speed, also decreased significantly from warm to cold treatments. However, peak gape opening and closing speeds for chews showed performance-enhancement, consistent with a previously demonstrated presence of elastic action in the Axolotl jaw system. Our results add to a relatively small body of evidence suggesting that elastic recoil plays significant roles in aquatic vertebrate feeding systems, and in cyclic food processing mechanisms.
Review of Methods for Animal Videography Using Camera Systems that Automatically Move to Follow the Animal
Authors: Straw Andrew D 
Published: June 2021

SynopsisDigital photography and videography provide rich data for the study of animal behavior and are consequently widely used techniques. For fixed, unmoving cameras there is a resolution versus field-of-view tradeoff and motion blur smears the subject on the sensor during exposure. While these fundamental tradeoffs with stationary cameras can be sidestepped by employing multiple cameras and providing additional illumination, this may not always be desirable. An alternative that overcomes these issues of stationary cameras is to direct a high-magnification camera at an animal continually as it moves. Here, we review systems in which automatic tracking is used to maintain an animal in the working volume of a moving optical path. Such methods provide an opportunity to escape the tradeoff between resolution and field of view and also to reduce motion blur while still enabling automated image acquisition. We argue that further development will be useful and outline potential innovations that may improve the technology and lead to more widespread use.
Localization and snaking in axially compressed and internally pressurized thin cylindrical shells
Authors: Groh Rainer M J , Hunt Giles W 
Published: June 2021

Abstract
This paper uncovers new manifestations of the homoclinic snaking mechanism in the post-buckling regime of a pressurized thin cylindrical shell under axial load. These new forms tend to propagate either wholly or partially in a direction that is orthogonal to the direction of the applied load and so, unlike earlier forms in Woods & Champneys (1999, Heteroclinic tangles in the unfolding of a degenerate Hamiltonian Hopf bifurcation. Phys. D, 129, 147–170), are fundamentally 2D in nature. The main effect of internal pressurization on the snaking mechanism is firstly to transition the circumferential multiplication of buckles from a one-tier pattern to a three-tier pattern. Secondly, internal pressurization can induce oblique snaking, whereby the sequential multiplication of buckles occurs in a helical pattern across the cylinder domain. For low levels of internal pressure, the single dimple remains—as in the unpressurized case—the unstable edge state that forms the smallest energy barrier around the stable pre-buckling equilibrium. For greater levels of pressure, the edge state changes to a single dimple surrounded by four smaller dimples. By tracing the limit point that denotes the onset of these edge states in the parameter space of internal pressure and axial load, we justify and validate the empirically derived design guideline for buckling of pressurized cylinders proposed by Fung & Sechler (1957, Buckling of thin-walled circular cylinders under axial compression and internal pressure. J. Aeronaut. Sci., 24, 351–356).
The Potential of the Singapore Convention on Mediation for Art and Cultural Property Disputes
Authors: Tanzi Attila M , Mason Paul Eric 
Published: June 2021

Abstract
The article focuses on the applicability of the 2019 Singapore Convention (UN Convention on International Settlement Agreements Resulting from Mediation) to art and cultural property disputes. The latter are characterized by highly diversified cultural, commercial, political and legal frameworks, which provide the grounds upon which these disputes have to be addressed. A preliminary analysis tackles the nature of the disputes under consideration, highlighting the potential combinations of disputing parties and the different dispute settlement mechanisms drawn by each international instrument. In the context of art-related disputes, mediation plays a critical role, which is witnessed by a number of case studies in the field. Thus, the settlement of international art and cultural heritage controversies may benefit from the entry into force of the Singapore Convention. The main features and challenges of the Convention are addressed by this contribution, with special regard to the effects that the treaty could have on international art and cultural property transactions and dispute resolution.
Children’s Sleep During COVID-19: How Sleep Influences Surviving and Thriving in Families
Authors: MacKenzie Nicole E , Keys Elizabeth , Hall Wendy A , Gruber Reut , Smith Isabel M , Constantin Evelyn , Godbout Roger , Stremler Robyn , Reid Graham J , Hanlon-Dearman Ana , Brown Cary A , Shea Sarah , Weiss Shelly K , Ipsiroglu Osman , Witmans Manisha , Chambers Christine T , Andreou Pantelis , Begum Esmot , Corkum Penny 
Published: June 2021

Abstract

Objective
The COVID-19 pandemic has the potential to disrupt the lives of families and may have implications for children with existing sleep problems. As such, we aimed to: (1) characterize sleep changes during the COVID-19 pandemic in children who had previously been identified as having sleep problems, (2) identify factors contributing to sleep changes due to COVID-19 safety measures, and (3) understand parents’ and children’s needs to support sleep during the pandemic.

Methods
Eighty-five Canadian parents with children aged 4–14 years participated in this explanatory sequential, mixed-methods study using an online survey of children’s and parents’ sleep, with a subset of 16 parents, selected based on changes in their children’s sleep, participating in semi-structured interviews. Families had previously participated in the Better Nights, Better Days (BNBD) randomized controlled trial.

Results
While some parents perceived their child’s sleep quality improved during the COVID-19 pandemic (14.1%, n = 12), many parents perceived their child’s sleep had worsened (40.0%, n = 34). Parents attributed children’s worsened sleep to increased screen time, anxiety, and decreased exercise. Findings from semi-structured interviews highlighted the effect of disrupted routines on sleep and stress, and that stress reciprocally influenced children’s and parents’ sleep.

Conclusions
The sleep of many Canadian children was affected by the first wave of the COVID-19 pandemic, with the disruption of routines influencing children’s sleep. eHealth interventions, such as BNBD with modifications that address the COVID-19 context, could help families address these challenges.
Printing Leibniz's Calculus: Dating and Numbering the Editions of the Nova Methodus pro Maximis et Minimis (October 1684)
Authors: Lemley Samuel V 
Published: June 2021

Abstract
The textual history of the first work on infinitesimal calculus and differentiation in print—Gottfried Wilhelm Leibniz’s ‘Nova methodus pro maximis et minimis …’ in the October 1684 instalment of the Leipzig scientific journal Acta Eruditorum—remains unstudied. Consequent to this inattention, extant copies of Leibniz’s article have been assigned to a single edition and a single press, despite evidence of substantive variation among them. This article examines the typographic and bibliographical evidence across multiple copies of the October 1684 instalment of the Acta to demonstrate that these extant copies in fact represent three separate editions printed on multiple presses over many years. This evidence, in turn, casts new light on both the complex printing history of the Acta Eruditorum in its first decade of publication (1682–93) and the distribution of learned periodicals in the seventeenth century.
Pericentric passage-driven star formation in satellite galaxies and their hosts: CLUES from local group simulations
Authors: Di Cintio Arianna , Mostoghiu Robert , Knebe Alexander , Navarro Julio F 
Published: June 2021

ABSTRACT
Local Group satellite galaxies show a wide diversity of star formation histories (SFHs) whose origin is yet to be fully understood. Using hydrodynamical simulations from the Constrained Local UniversE project, we study the SFHs of satellites of Milky Way-like galaxies in a cosmological context: while in the majority of the cases the accretion on to their host galaxy causes the satellites to lose their gas, with a subsequent suppression in SF, in about 25 per cent of our sample we observe a clear enhancement of SF after infall. Peaks in SF clearly correlate with the satellite pericentric passage around its host and, in one case, with a satellite–satellite interaction. We identify two key ingredients that result in enhanced SF after infall: galaxies must enter the host’s virial radius with a reservoir of cold gas Mgas, inf/Mvir, inf ≳ 10−2 and with a minimum pericentric distance ≳10 kpc (mean distance ∼50 kpc for the full sample), in order to form new stars due to compression of cold gas at pericentric passage. On the other hand, satellites that infall with little gas or whose pericentric distance is too small, have their gas ram-pressure stripped and subsequent SF quenched. The pericentric passage of satellites likewise correlates with SF peaks in their hosts, suggesting that this mechanism induces bursts of SF in satellites and central galaxies alike, in agreement with recent studies of our Galaxy’s SFH. Our findings can explain the recently reported multiple stellar populations observed in dwarf galaxies such as Carina and Fornax, and should be taken into account in semi-analytic models of galaxy formation and satellite quenching.
The role of human endogenous retroviruses in gliomas: from etiological perspectives and therapeutic implications
Authors: Shah Ashish H , Gilbert Mark , Ivan Michael E , Komotar Ricardo J , Heiss John , Nath Avindra 
Published: June 2021

AbstractAccounting for approximately 8% of the human genome, human endogenous retroviruses (HERVs) have been implicated in a variety of cancers including gliomas. In normal cells, tight epigenetic regulation of HERVs prevent aberrant expression; however, in cancer cells, HERVs expression remains pervasive, suggesting a role of HERVs in oncogenic transformation. HERVs may contribute to oncogenesis in several ways including insertional mutagenesis, chromosomal rearrangements, proto-oncogene formation, and maintenance of stemness. On the other hand, recent data has suggested that reversing epigenetic silencing of HERVs may induce robust anti-tumor immune responses, suggesting HERVs’ potential therapeutic utility in gliomas. By reversing epigenetic modifications that silence HERVs, DNA methyltransferase, and histone deacetylase inhibitors may stimulate a viral-mimicry cascade via HERV-derived dsRNA formation that induces interferon-mediated apoptosis. Leveraging this anti-tumor autoimmune response may be a unique avenue to target certain subsets of epigenetically-dysregulated gliomas. Nevertheless, the role of HERVs in gliomas as either arbitrators of oncogenesis or forerunners of the innate anti-tumor immune response remains unclear. Here, we review the role of HERVs in gliomas, their potential dichotomous function in propagating oncogenesis and stimulating the anti-tumor immune response, and identify future directions for research.