bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Civil Code of Ukraine – A Reliable Regulator of Civil Relations in Civil Society
Authors: Kuznietsova Nataliia S. , Petryshyn Oleksandr V. , Pylypenko Denys S. 
Published: June 2021

Abstract
This article is a study of the Civil Code of Ukraine as the main regulator of civil relations in civil society. The history of adoption of the Civil Code of Ukraine and its conceptual foundations were reviewed. Particular attention is paid to the problem of dualism of private law in Ukraine. The structure and content of the Civil Code of Ukraine were analysed. Attention is also paid to the main novelties of the Civil Code of Ukraine. The principal rules for the regulation of legal entities were analysed. Novelties in defining the object composition of civil legal relations are considered. Particular attention is paid to the main directions of modern scientific research in the field of the civil law of Ukraine. The study confirms the urgent need for a thorough recodification of the Ukrainian civil law, with mandatory consideration of the experience of the implementation of modern recodifications in many European countries.
Convergence of the Contract Law of Ukraine and EU Member States
Authors: Luts Volodymyr V. , Hryniak Andrii B. , Pleniuk Mariana D. , Krykoves Valeriia V. 
Published: June 2021

Abstract
The purpose of the article is to analyse the modern contract law of Ukraine, which requires convergence with the provisions of the contract law of the countries of the European Community. The paper uses general scientific and special legal methods of scientific knowledge of private-law relations. The leading method of investigation of this issue is the modelling technique. In general, the issues of contractual regulation of private-law relations both in European Union law and in Ukraine are primarily addressed in terms of enhancing the role of the contract and shifting the emphasis from the statutory to individual regulation; strengthening the tendencies of the better legal protection of the interests of the weak side of the contractual obligation. Attention is drawn to the necessity of the introduction of a European methodology of binding law, which is reflected in the need for a combination of new and already known effective legal structures.
Implementation of the Right to Inheritance: Problems of Theory and Practice
Authors: Bychkova Svitlana S. , Bilianska Nataliia V. , Fedosieieva Tetiana R. 
Published: June 2021

Abstract
The article is devoted to the research into problematic aspects of exercising the right of inheritance by different categories of entities. As a result of the research conducted, recommendations for improvements to Ukrainian legislation have been developed. The status of a child born after 10 months and as a result of the use of assisted reproductive technologies after the death of one spouse should be determined at the legislative level. It also would be expedient in the Civil Code of Ukraine to fix the testator’s rights to settle the issue of birth of his children in the will through the use of assisted reproductive technologies after his death and to appoint such children as heirs. In addition, the Civil Code of Ukraine should provide for the possibility of individuals recognised as missing, to be heirs, and to secure the right to have a guardian over the property of such persons.
A Nonlinear Multiscale Theory of Atmospheric Blocking: Structure and Evolution of Blocking Linked to Meridional and Vertical Structures of Storm Tracks
Authors: Luo Dehai , Zhang Wenqi 
Published: June 2021

AbstractThis paper examines the impact of the meridional and vertical structures of a preexisting upstream storm track (PUST) organized by preexisting synoptic-scale eddies on eddy-driven blocking in a nonlinear multiscale interaction model. In this model, the blocking is assumed, based on observations, to be comprised of barotropic and first baroclinic modes, whereas the PUST consists of barotropic, first baroclinic, and second baroclinic modes. It is found that the nonlinearity (dispersion) of blocking is intensified (weakened) with increasing amplitude of the first baroclinic mode of the blocking itself. The blocking tends to be long lived in this case. The lifetime and strength of blocking are significantly influenced by the amplitude of the first baroclinic mode of blocking for given basic westerly winds (BWWs), whereas its spatial pattern and evolution are also affected by the meridional and vertical structures of the PUST. It is shown that the blocking mainly results from the transient eddy forcing induced by the barotropic and first baroclinic modes of PUST, whereas its second baroclinic mode contributes little to the transient eddy forcing. When the PUST shifts northward, eddy-driven blocking shows an asymmetric dipole structure with a strong anticyclone–weak cyclone in a uniform BWW, which induces northward-intensified westerly jet and storm-track anomalies mainly on the north side of blocking. However, when the PUST has no meridional shift and is mainly located in the upper troposphere, a north–south antisymmetric dipole blocking and an intensified split jet with maximum amplitude in the upper troposphere form easily for vertically varying BWWs without meridional shear.
Invented Forces in Supercell Models
Authors: Davies-Jones Robert 
Published: June 2021

AbstractThis paper examines methods used in supercell models to maintain a steady, sheared, horizontally uniform environment with a three-force balance in the planetary boundary layer (PBL) and a two-force balance above it. Steady environments are maintained while ignoring the thermal-wind balance that permits large shear above the PBL. The Taylor-Proudman theorem indicates that wind profiles above the PBL must be unidirectional for balanced environments. In principle, supercell models that do not accommodate thermal advection should not support balanced steady environments with veering horizontally uniform winds.Recent methods add a permanent, pervasive, horizontal external force that varies only with height. By adding two more degrees of freedom, this force circumvents the Taylor-Proudman theorem and enables a static, horizontally uniform environment for any wind profile. It succeeds by adding spurious energy in lieu of flow towards low pressure to offset frictional loss of kinetic energy. However, the artificial force has downsides. It decouples the environmental horizontal equation of motion from the hydrostatic equation and the thermodynamics from the dynamics. It cancels environmental friction and the part of the Coriolis force that acts on the environmental wind. Within the storm, its curl can speciously generate significant horizontal vorticity near the ground. Inaccuracies arise in circulations around material circuits because of modifications by the artificial force and resulting miscalculations of parcel trajectories. Doubt is cast on conclusions about tornadogenesis drawn from recent simulations that contain an invented force.
A New Framework for Identifying and Investigating Seasonal Climate Extremes
Authors: Röthlisberger Matthias , Hermann Mauro , Frei Christoph , Lehner Flavio , Fischer Erich M. , Knutti Reto , Wernli Heini 
Published: June 2021

AbstractPrevious studies have recognized the societal relevance of climatic extremes on the seasonal time scale and examined physical processes leading to individual high-impact extreme seasons (e.g., extremely wet or warm seasons). However, these findings have not yet been generalized beyond case studies since at any specific location only very few seasonal events of such rarity occurred in the observational record. In this concept paper, a pragmatic approach to pool seasonal extremes across space is developed and applied to investigate hot summers and cold winters in ERA-Interim and the Community Earth System Model Large Ensemble (CESM-LENS). We identify spatial extreme season objects as contiguous regions of extreme seasonal mean temperatures based on statistical modeling. Regional pooling of extreme season objects in CESM-LENS then yields considerable samples of analogs to even the most extreme ERA-Interim events. This approach offers numerous opportunities for systematically analyzing large samples of extreme seasons, and several such analyses are illustrated. We reveal a striking co-occurrence of El Niño to La Niña transitions and the largest ERA-Interim midlatitude extreme summer events. Moreover, we perform a climate model evaluation with regard to extreme season size and intensity measures and estimate how often an extreme winter like the cold North American 2013/14 winter is expected anywhere in midlatitude regions. Furthermore, we present a large set of simulated analogs to this event, which makes it possible to study commonalities and differences of their underlying physical processes. Finally, substantial but spatially varying climatological differences in the size of extreme summer and extreme winter objects are identified.
Exploring the Relationship between Shared Decision-Making, Patient-Centered Medicine, and Evidence-Based Medicine
Authors: Páez Gustavo , Forte Daniel Neves , Gabeiras María del Pilar López 
Published: June 2021

Shared decision-making is a possible link between the best of patient-centered medicine and evidence-based medicine. This article seeks to describe the link between them. It discusses to what extent the integration of such perspectives is successful in assuring respect for the patient’s autonomy. From the evidence herein, we conclude that if the doctor–patient relationship and communication are strengthened to cover all issues relevant to the patient’s health and values, is it possible for him or her to achieve more autonomous decisions by this linkage of shared decision-making and patient-centered medicine? Summary: Shared decision-making is a possible link between the best of patient-centered medicine and evidence-based medicine. This article seeks to describe the link between them.
Periocular apocrine adenocarcinoma presenting as an orbital mass: clinicopathological features and management in four patients
Authors: Koç İrem , Kiratli Hayyam , Kapucu Yasemin , Söylemezoğlu Figen 
Published: June 2021

Purpose: Apocrine adenocarcinoma is a cutaneous adnexal malignancy which can rarely arise from ocular structures. In this retrospective study, we report our experience with four patients who had primary periocular apocrine adenocarcinoma initially presenting with an orbital tumor. Methods: Data extracted included demographics, clinical, imaging, and histopathological features, and treatment outcomes. Results: The definitive diagnosis was established after an incisional biopsy in all cases. Two patients were then managed with exenteration. The third patient underwent local resection followed by radiotherapy but had to be exenterated because of new tumor formation 7 years later. The fourth patient had to be managed with oral bicalutamide which kept the tumor stable for 3 years. Recurrence-free survival for the radical surgical treatment group was 10, 6, and 7 years respectively. Conclusion: Periocular apocrine adenocarcinoma may insidiously develop as an orbital mass without any clinically detectable primary eyelid skin or conjunctival lesions. This tumor must be in the differential diagnosis of medially located ill-defined orbital masses in patients over 50 years of age. Orbital exenteration appeared as an effective treatment of apocrine adenocarcinoma with orbital extension. Anti-androgenic treatment in an androgen receptor-positive tumor provided temporary local tumor control.
Multicenter Experience With Large Diameter Balloon-Expandable Stent-Grafts for the Treatment of Infrarenal Penetrating Aortic Ulcers
Authors: Stana Jan , Fernandez Prendes Carlota , Kruszyna Lukasz , Passaloglou Ioannis Thomas , Ruffino Maria Antonella , Reyes Valdivia Andres , del Castro Madrazo Jose Antonio , Oikonomou Kyriakos , Chan Hon Lai , Makaloski Vladimir , Tsilimparis Nikolaos 
Published: June 2021

Purpose To describe the use of large-diameter balloon-expandable stent-grafts (BeGraft aortic stent-graft, Bentley InnoMed GmbH, Hechingen, Germany) in the treatment of infrarenal penetrating aortic ulcer (iPAU). Materials and Methods Retrospective analysis of patients undergoing endovascular treatment with the BeGraft aortic stent-graft in 8 European centers from January 2017 to October 2020. Demographics, perioperative data, and midterm outcomes were collected. Endpoints of the study were technical feasibility, early mortality, and morbidity. Results A total of 40 patients were included. The mean age was 73.9±7.05 years and 63.2% were male. Indications for treatment included size and morphology (65%), presence of symptoms (29.5%), and contained ruptures (5.5%). Urgent treatment was performed in 5% of cases. Technical success was 97.5%. Median operation time was 58 minutes (19–170 minutes), with 27.5% of patients having additional procedures during the main intervention (1 additional repair with a C-TAG (W.L. Gore & Associates, Inc, Flagstaff, AZ, USA) thoracic endoprosthesis, 5 covered endovascular reconstruction of aortic bifurcation procedures, 3 extensions with proximal cuffs, and 2 percutaneous angioplasties of the common iliac arteries). Percutaneous femoral access was used in 72.5%, while groin cut-down was performed in 27.5%. Repair was successful with only 1 stent in 45% of cases, while 37.5% required 2 stents and nearly 17.5% required 3/4 stent-grafts. The 30-day mortality was 0%, with a 2.5% reintervention rate (1 patient required evacuation of an intra-abdominal hematoma). Median follow-up was 13.9 months (2–39 months), during which no vascular-related reinterventions or deaths were reported. In 4 patients, a type II endoleak was observed. No cases of graft migration, thrombosis, or stent-fracture were observed. Conclusions The treatment of iPAU with the BeGraft aortic stent-graft in a selective patient group is feasible with low rate of perioperative morbidity and mortality. Balloon-expandable stent-grafts offer the option to repair iPAUs with a shorter coverage of the aorta using low-profile sheath, that enables treatment in the presence of calcified access vessels and small diameter aortic bifurcations.
Comparison of healthcare resource utilization and medical costs between patients with seropositive and seronegative rheumatoid arthritis
Authors: Kim Hyoungyoung , Cho Soo-Kyung , Choi Seongmi , Im Seul Gi , Jung Sun-Young , Jang Eun Jin , Sung Yoon-Kyoung 
Published: June 2021

Objectives: To compare healthcare utilization and medical costs between patients with seronegative (SN) and seropositive (SP) rheumatoid arthritis (RA). Methods: We conducted a nationwide population study using the Korean health insurance claims database in 2016. We divided patients with RA into SN and SP groups and compared healthcare utilization including medications, medical utilization, and direct medical costs for 1 year between the groups in a cross-sectional analysis. Differences in costs between patients with SPRA and SNRA were assessed using the quantile regression model. We performed longitudinal analysis using data from 2012 and 2016 to examine changes over time. Results: A total of 103,815 SPRA and 75,809 SNRA patients were included in the analyses. The SPRA group used significantly more methotrexate (73.2% versus 30.3%) and biologic agents (7.9% versus 2.9%) than the SNRA group. The number of RA-related outpatient visits [6.0 ± 3.7 versus 4.4 ± 4.0 times/year, standardized difference (SD) = 0.41] and annual medical costs per patient ($1027 versus $450/year, SD = 0.25) were higher in the SPRA group than the SNRA group. Quantile regression results indicated that the incremental cost of seropositivity on total medical costs of RA patients gradually increased as medical costs approached the upper quantile. The annual direct medical costs for each patient between 2012 and 2016 increased in both groups: by 25.1% in the SPRA group and 37.6% in the SNRA group. Conclusion: Annual RA-related direct medical costs and RA-related healthcare utilization per patient are higher in patients with SPRA than those with SNRA.
Validation of reference genes for whole blood gene expression analysis in cord blood of preterm and full-term neonates and peripheral blood of healthy adults
Authors: Hieronymus Kristin , Dorschner Benjamin , Schulze Felix , Vora Neeta L. , Parker Joel S. , Winkler Jennifer Lucia , Rösen-Wolff Angela , Winkler Stefan 
Published: June 2021

Abstract
Background
Preterm birth is the leading cause of neonatal morbidity and mortality, but research efforts in neonatology are complicated due to the unavailability of large volume blood samples. Whole blood assays can be used to overcome this problem by performing both functional and gene expression studies using small amounts of blood. Gene expression studies using RT-qPCR estimate mRNA-levels of target genes normalized to reference genes. The goal of this study was to identify and validate stable reference genes applicable to cord blood samples obtained from developing neonates of different gestational age groups as well as to adult peripheral blood samples. Eight reference gene candidates (ACTB, B2M, GAPDH, GUSB, HPRT, PPIB, RPLP0, RPL13) were analyzed using the three published software algorithms Bestkeeper, GeNorm and NormFinder.

Results
A normalization factor consisting of ACTB and PPIB allows for comparative expression analyses of neonatal samples from different gestational age groups. Normalization factors consisting of GAPDH and PPIB or ACTB and GAPDH are suitable when samples from preterm and full-term neonates and adults are compared. However, all candidate reference genes except RPLP0 exhibited significant intergroup gene expression variance and a higher gene expression towards an older age which resulted in a small but statistically significant systematic bias. Systematic analysis of RNA-seq data revealed new reference gene candidates with potentially superior stability.

Conclusions
The current study identified suitable normalization factors and proposed the use of the additional single gene RPLP0 to avoid systematic bias. This combination will enable comparative analyses not only between neonates of different gestational ages, but also between neonates and adults, as it facilitates more detailed investigations of developmental gene expression changes. The use of software algorithms did not prevent unintended systematic bias. This generally highlights the need for careful validation of such results to prevent false interpretation of potential age-dependent changes in gene expression. To identify the most stable reference genes in the future, RNA-seq based global approaches are recommended.
Insertion of an endogenous Jaagsiekte sheep retrovirus element into the BCO2 - gene abolishes its function and leads to yellow discoloration of adipose tissue in Norwegian Spælsau (Ovis aries)
Authors: Kent Matthew , Moser Michel , Boman Inger Anne , Lindtveit Kristine , Árnyasi Mariann , Sundsaasen Kristil Kindem , Våge Dag Inge 
Published: June 2021

Abstract
Background
The accumulation of carotenoids in adipose tissue leading to yellow fat is, in sheep, a heritable recessive trait that can be attributed to a nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene. However, not all sheep breeds suffering from yellow fat have this nonsense mutation, meaning that other functional mechanisms must exist. We investigated one such breed, the Norwegian spælsau.

Results
In spælsau we detected an aberration in BCO2 mRNA. Nanopore sequencing of genomic DNA revealed the insertion of a 7.9 kb endogenous Jaagsiekte Sheep Retrovirus (enJSRV) sequence in the first intron of the BCO2 gene. Close examination of its cDNA revealed that the BCO2 genes first exon was spliced together with enJSRV-sequence immediately downstream of a potential -AG splice acceptor site at enJSRV position 415. The hybrid protein product consists of 29 amino acids coded by the BCO2 exon 1, one amino acid coded by the junction sequence, followed by 28 amino acids arbitrary coded for by the enJSRV-sequence, before a translation stop codon is reached.

Conclusions
Considering that the functional BCO2 protein consists of 575 amino acids, it is unlikely that the 58 amino acid BCO2/enJSRV hybrid protein can display any enzymatic function. The existence of this novel BCO2 allele represents an alternative functional mechanism accounting for BCO2 inactivation and is a perfect example of the potential benefits for searching for structural variants using long-read sequencing data.
Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES)
Authors: Nkeh-Chungag Benedicta Ngwenchi , Engwa Godwill Azeh , Businge Charles , Mdondolo Mziwohlanga , Pajaro Medina Magdevy , Goswami Nandu 
Published: June 2021

Abstract
Background
The risk of cardiovascular diseases (CVDs) is becoming more prevalent in pregnant women though not much data is available for pregnant women with human immunodeficiency virus (HIV). Foetoplacental vascular endothelial dysfunction is thought to be at the origin of chronic diseases such as diabetes and obesity later on in life. Because HIV and anti-retroviral treatment (ARTs) are associated with endothelial dysfunction, children exposed in utero to these conditions may be at greater risk of developing CVDs. Despite the high prevalence of HIV in pregnant South African women, little is known about the effects of ART on the cardiovascular health of the mother and offspring. Hence, the proposed study intends to investigate how HIV/ARTs may affect the cardiovascular health of the mother and offspring at different time points during the pregnancy and up to 2 years after birth.

Methods
A longitudinal case–control study in HIV positive pregnant women on ART and HIV negative pregnant women will be conducted. All pregnant women will be assessed for cardio-metabolic risk factors and markers (lipids, anthropometric and glycaemic indies, oxidative stress), hemodynamic status (blood pressure parameters) and vascular function (arterial compliance, retinal microvasculature, uterine artery mean pulsatility index). Child health will be monitored in utero and postnatally via routine foetal health screening, placental integrity, anthropometry, blood pressure parameters, markers of oxidative stress and endothelial function in cord blood and cardiovascular epigenetic markers in urine.

Discussion
There is a paucity of studies in South Africa and sub-Sahara Africa as a whole that utilised a longitudinal study model to assess the effects of ARTs on vascular endothelial changes in pregnant women living with HIV and the cardiometabolic health of their offspring. This study will therefore help to monitor changes in cardiometabolic risk during pregnancy and in children exposed in utero to HIV-infection and ART use. Findings from this study will provide useful information for developing guidelines on the use of ARTs in pregnancy and management of cardiometabolic health of the offspring of HIV positive mothers.