bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management status of mud crab fisheries in selected areas of FMA 713, East Kalimantan, Indonesia using the Indonesian Ecosystem Approach to Fisheries Management (EAFM) Assessment Methodology
Authors: Syahdan Muhammad , Rosadi Erwin , Nursalam  , Dewi Ira Puspita , Anshary Ananda Fitrian 
Published: May 2021

Abstract
The selected study area in Fisheries Management Area (FMA) 713 in Kartanegara District, East Kalimantan Province, Indonesia has extensive mangrove forests with suitable habitat for mud crabs (Scylla sp.), a valuable fisheries resource. Concerns have been raised regarding reported declines in the abundance of mud crabs and in the condition of their mangrove habitat. To evaluate the management status of the mud crab fishery in this area, an assessment was carried out using the Indonesian Ecosystem Approach to Fisheries Management (EAFM) methodology. The 25 indicators assessed represent 6 domains: Fisheries Resources, Habitat and Ecosystems, Fishing Technology, Social, Economic, and Institutional. The flag model technique was applied using multi-criteria analysis through an expansion of the composite index. The results indicate that the overall management status of mud crab fisheries in Kutai Kartanegara District was in the Moderate class (on a scale of Poor, Insufficient, Moderate, Good, Excellent). Indicators in the Habitat and Ecosystems, Fishing Technology, and Institutional Domains highlighted areas of concern where improvements are needed. The Fisheries Resources Domain aggregate status (moderate) indicated that wild mud crab stocks were still reasonably abundant and reliable, supporting the moderate status in the Social and Economic Domains, which relate to the welfare of fishing communities. The Institutional Domain status was in the poor category. Good governance measures to improve the Institutional Domain indicators have the potential to strengthen the other domains, in particular the Habitat and Ecosystem Domain and the Fishing Technology Domain, and to improve the overall EAFM status of the mud crab fishery in the future.
Plankton’s abundance and its implications for Sardinella lemuru catch in Prigi waters
Authors: Sartimbul Aida , Trishnayana Egha , Rohadi Erfan , Muslihah Nurul , Lutfi Oktiyas M , Iranawati Feni , Harlyan Ledhyane Ika , Wulandari Erawati , Sambah A B 
Published: May 2021

Abstract

Sardinella lemuru is well known as a dominant fish in Bali Strait. However, since 2010 the stocks have collapsed. Surprisingly, at the end of 2019 it was caught very abundantly in Prigi waters, Trenggalek, reaching 56.42% of the production by volume and 39.44% in value. The reason for this abundance is thought to be the abundant availability of food in nature. This study aimed to analyse the abundance of plankton in relation to the abundance of S. lemuru in Prigi waters at the end of November 2019. A total of 100 S. lemuru samples were caught using a purse seiner, while marine plankton were collected using a 20μm plankton net with a vertical method at 5 sampling sites in S. lemuru fishing grounds in Prigi waters. The morphology, morphometric and meristic characters of the S. lemuru specimens were analysed, as well as the gut contents. Plankton samples collected from the sea and S. lemuru guts were identified and their abundance analysed. The S. lemuru samples had a mean total length (TL) of 16.47 ± 0.19 cm. The plankton from the seawater consists of 52.8% zooplankton and 47.2% phytoplankton, consisting of 21 genera of phytoplankton and 12 genera of zooplankton. Actinocyclus dominated the phytoplankton group with an abundance of 14,098 ind/m3, while the zooplankton group was dominated by Acartia with an abundance of 15,592 ind/m3. Correlation analysis shows the value of the correlation coefficient between phytoplankton in the waters and the S. lemuru was r = 0.920 with a determination coefficient of 84.9%. The abundance of S. S. lemuru in November 2019 was due to the abundant availability of food in the fishing area, when phytoplankton is the main food choice for S. lemuru.
Chiral glass of charged DNA rods, cavity loops
Authors: Kang Kyongok 
Published: May 2021

Abstract
Recently, the collective phase behaviors of charged DNA-viruses (rods) are explored in various low ionic strengths, where much slowing down relaxations are observed in equilibrium. These phases are distinguished by crossing the critical ionic strength, where the salt-dependent effective microscopic dynamics are important with non-monotonic multi-phase boundaries. This is also interested in terms of phase transition and replica symmetry breaking (RSB), realized by the divergence of relaxation time and the exponent power of correlation lengths in dynamic disorderorder transitions. RSB occurs as the result of many-body interactions of randomized orientations. Here, in this paper, one of the chiral mesophases, the X-pattern is highlighted for its long-time metastable state consisting of cavity loops bounded within the planar nematic, as a new type of a glass, noted as a chiral glass. The chiral glass is discussed in terms of the divergences for relaxations in the characteristic time as well the inverse of an optical pitch length, which are analyzed in the long-time-lapsed orientation textures via image-time correlations. The outcome highlights interesting aspects of charge effect in the ‘twist’ elasticity energy for optimizing the long-ranged repulsive electrostatic interactions among charged DNA rods.
Image segmentation for neuroscience: lymphatics
Authors: Tabassum N , Wang J , Ferguson M , Herz J , Dong M , Louveau A , Kipnis J , Acton S T 
Published: May 2021

Abstract
A recent discovery in neuroscience prompts the need for innovation in image analysis. Neuroscientists have discovered the existence of meningeal lymphatic vessels in the brain and have shown their importance in preventing cognitive decline in mouse models of Alzheimer’s disease. With age, lymphatic vessels narrow and poorly drain cerebrospinal fluid, leading to plaque accumulation, a marker for Alzheimer’s disease. The detection of vessel boundaries and width are performed by hand in current practice and thereby suffer from high error rates and potential observer bias. The existing vessel segmentation methods are dependent on user-defined initialization, which is time-consuming and difficult to achieve in practice due to high amounts of background clutter and noise. This work proposes a level set segmentation method featuring hierarchical matting, LyMPhi, to predetermine foreground and background regions. The level set force field is modulated by the foreground information computed by matting, while also constraining the segmentation contour to be smooth. Segmentation output from this method has a higher overall Dice coefficient and boundary F1-score compared to that of competing algorithms. The algorithms are tested on real and synthetic data generated by our novel shape deformation based approach. LyMPhi is also shown to be more stable under different initial conditions as compared to existing level set segmentation methods. Finally, statistical analysis on manual segmentation is performed to prove the variation and disagreement between three annotators.
The Impact of Surgical Procedures During Septorhinoplasty on the Intraoperative Pain Response
Authors: Ince Bilsev , Zuhour Moath , Yusifov Merve , Erol Atilla , Dadaci Mehmet 
Published: May 2021

Abstract

Background
During septorhinoplasty, many different surgical procedures are employed to bring the nose to the desired shape and solve breathing complaints. As a matter of course, intraoperative pain response occurs due to these procedures.

Objectives
With this study, the authors aimed to evaluate the intraoperative pain formed during septorhinoplasty surgery with numerical values and to determine which stage of surgery is more painful.

Methods
Between April 2019 and March 2020, a total of 30 female patients who were planned to undergo septorhinoplasty were included in this prospective study. Standard anesthesia and analgesia were applied to all patients. During surgery, state entropy measure was utilized to evaluate the depth of anesthesia, and Surgical Pleth Index was employed to evaluate the response of the central nervous system to pain “nociception.”

Results
The age of the patients ranged from 18 to 42 years (average, 25.3 ± 6.1 years). The average value of state entropy recorded during the surgery for all patients was found to be 45.43 ± 5.37. The mean beginning Surgical Pleth Index value recoded from all of the patients was 23.4 ± 8.84 compared with the beginning value; the values recorded during periost dissection, lateral osteotomy, and lower turbinate lateralization were statistically significantly higher (P &lt; 0.005).

Conclusions
Although sufficient depth of anesthesia and standard protocol of analgesia were applied, pain response was found to be significantly higher at some procedures during septorhinoplasty. The authors think that increasing the depth of anesthesia during these procedures will increase the comfort of this operation by inhibiting pain response.

Level of Evidence: 4
Males perceive honest information from female released sex pheromone in a moth
Authors: Gonzalez-Karlsson Adrea , Golov Yftach , Steinitz Hadass , Moncaz Aviad , Halon Eyal , Horowitz A Rami , Goldenberg Inna , Gurka Roi , Liberzon Alexander , Soroker Victoria , Jurenka Russell , Harari Ally R 
Published: May 2021

AbstractThere is accumulating evidence that male insects advertise their quality to conspecific females through pheromones. However, most studies of female released sex pheromone assume information transfer regarding merely the species of the female and her mating status. We show that more information is conveyed through the female sex pheromone, positioning it as an honest sexual trait. We demonstrate that females in bad physical conditions (small, starved, or old) lay significantly fewer eggs than females in good conditions (large, fed, or young). The ratio of components in the sex pheromone blend in gland extracts of the female pink bollworm moths provided honest information on most of the phenotypic conditions tested, whereas the pheromone amount in the glands provided an honest signal of quality for extreme phenotypes only. Moreover, males used the information conveyed by the female pheromone to choose their mates, approaching females that signaled higher reproductive potential. In addition, when simulating the female effect, using the synthetic pheromone blend that represents higher quality females (0.6:0.4 ZZ:ZE), more males were attracted to this blend than to the blend representing the population mean (0.5:0.5 ZZ:ZE). Both, female advertisement for males and the male choosiness, suggest that pheromones have evolved as sexual traits under directional, sexual selection. We suggest that the pheromone blend may serve as a multicomponent signal whereby each component adds information concerning the current condition of the female, and all are necessary to elicit a mate searching response.
Natural noise affects conspecific signal detection and territorial defense behaviors in songbirds
Authors: Reed Veronica A , Toth Cory A , Wardle Ryan N , Gomes Dylan G E , Barber Jesse R , Francis Clinton D 
Published: May 2021

Abstract
Recent research suggests that anthropogenic noise can substantially alter animal behavior. Although there are many sources of natural background noise, the relative influence of these sounds on behavior has received much less attention. Using landscape-scale playbacks of rushing rivers and crashing ocean surf, we investigated how habitat appropriate natural noise alters territorial defense behaviors in lazuli buntings (Passerina amoena) occupying riparian areas and spotted towhees (Pipilo maculatus) in riparian and coastal areas when exposed to simulated intruder song. We also incorporated naturally occurring cicada noise as an acoustic source influencing lazuli bunting behavior. Both songbird species possess songs that share substantial spectral overlap with low-frequency, water-generated noise, and lazuli bunting song shares an additional high-frequency overlap with cicada calls. Thus, there is potential for background acoustic conditions to mask conspecific signals. We found that detection and discrimination of conspecific playback occurred more slowly for both species as background sound levels increased. Lazuli buntings also exhibited complex flight behavior in noise, suggesting they respond differently depending on the amplitude and type of background noise (with versus without cicada calls). Our results suggest natural noise can impair territorial defense behaviors in songbirds, highlighting natural soundscapes as an under-appreciated axis of the environment.
LSTM-PHV: prediction of human-virus protein–protein interactions by LSTM with word2vec
Authors: Tsukiyama Sho , Hasan Md Mehedi , Fujii Satoshi , Kurata Hiroyuki 
Published: May 2021

Abstract
Viral infection involves a large number of protein–protein interactions (PPIs) between human and virus. The PPIs range from the initial binding of viral coat proteins to host membrane receptors to the hijacking of host transcription machinery. However, few interspecies PPIs have been identified, because experimental methods including mass spectrometry are time-consuming and expensive, and molecular dynamic simulation is limited only to the proteins whose 3D structures are solved. Sequence-based machine learning methods are expected to overcome these problems. We have first developed the LSTM model with word2vec to predict PPIs between human and virus, named LSTM-PHV, by using amino acid sequences alone. The LSTM-PHV effectively learnt the training data with a highly imbalanced ratio of positive to negative samples and achieved AUCs of 0.976 and 0.973 and accuracies of 0.984 and 0.985 on the training and independent datasets, respectively. In predicting PPIs between human and unknown or new virus, the LSTM-PHV learned greatly outperformed the existing state-of-the-art PPI predictors. Interestingly, learning of only sequence contexts as words is sufficient for PPI prediction. Use of uniform manifold approximation and projection demonstrated that the LSTM-PHV clearly distinguished the positive PPI samples from the negative ones. We presented the LSTM-PHV online web server and support data that are freely available at http://kurata35.bio.kyutech.ac.jp/LSTM-PHV.
Pupal colour plasticity in the butterfly Catopsilia pomona (Lepidoptera: Pieridae)
Authors: Yumnam Tarunkishwor , Banerjee Birupaksha , Kodandaramaiah Ullasa 
Published: May 2021

Abstract
Pupal colour plasticity (PCP) in many lepidopterans can be adaptive by helping pupae match their background colours. Studies on PCP, most of which have been laboratory-based, have largely used human assessment of colour to categorize pupae as green or brown. This binary categorization limits the understanding of finer pupal colour variations and their function. We conducted a study of PCP in the butterfly Catopsilia pomona by comparing laboratory-reared and wild populations. Considering pupal colour as a continuous variable, we showed that a large proportion of the pupae matched the colours of their substrates, with leaf-borne pupae tending to be greener and off-leaf pupae browner. Pupal colour also responded to the leaf substrate’s finer colour variations, highlighting the importance of treating pupal colour as a continuous variable. Compared to the wild population, the laboratory population had more green pupae on off-leaf substrates. Our study thus illustrates that caution should be used when extrapolating the results from laboratory-based studies to the natural world. In leaf-borne wild pupae, pupation position on the leaf, the thickness of the midrib where pupation occurred and the leaf’s length influenced the pupal colour. Our study underscores the need for further research on PCP as a background-matching strategy in light of predation.
RP11-51O6.1 sponges miR-206 to accelerate colorectal cancer carcinogenesis and metastasis through upregulating YAP1
Authors: Zhu Xiaojian , Zhu Jinfeng , Tan Ting , Bu Fanqin , Zhao Jiefeng , Luo Chen , Luo Hongliang 
Published: May 2021

Abstract
Long non-coding RNAs (lncRNAs) have been characterized by playing a crucial role in tumorigenesis. However, the detail biological function and clinical importance of lncRNAs in colorectal cancer (CRC) are unclear and have attracted different levels of in-depth research. In this context, we explored the differentially expressed profiles of lncRNAs in six CRC tissues and three adjacent non-tumor tissues from RNA-sequencing (RNA-seq) study and noted a lncRNA, RP11-51O6.1, which is markedly overexpressed in CRC tissues, particularly in aggressive cases. Impressively, an elevated RP11-51O6.1 level was highly correlated with poor prognosis in clinical patients. Functional analyses revealed that RP11-51O6.1 could promote cell proliferation in vitro and in vivo. Furthermore, we reported that RP11-51O6.1 enhances cell migration and invasion in vitro. Mechanistic studies (Bioinformatics binding site analyses, the Luciferase reporter, Ago2 immunoprecipitation, the RNA pull-down, immunofluorescence colocalization, rescued assays and western blotting) implicated that RP11-51O6.1 could regulate YAP1 expression by competitively sponging miR-206 and blocking its activity in promoting CRC progression. Conclusively, our findings identify a novel RP11-51O6.1/miR-206/YAP1 regulatory axis that participates in CRC progression and development, suggesting RP11-51O6.1 is an exploitable biomarker and appealing therapeutic target in treating CRC.
Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences
Authors: Kushki Azadeh , Cardy Robyn E , Panahandeh Sina , Malihi Mahan , Hammill Christopher , Brian Jessica , Iaboni Alana , Taylor Margot J , Schachar Russell , Crosbie Jennifer , Arnold Paul , Kelley Elizabeth , Ayub Muhammad , Nicolson Robert , Georgiades Stelios , Lerch Jason P , Anagnostou Evdokia 
Published: May 2021

Abstract
Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive–compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and diagnosis-agnostic approach to discover brain correlates of social communication differences in ASD, ADHD, and OCD, and subgroups of individuals who share similar patterns of brain-behavior associations. A machine learning pipeline (regression clustering) was used to discover the pattern of association between structural brain measures (volume, surface area, and cortical thickness) and social communication abilities. Participants (n = 416) included children with a diagnosis of ASD (n = 192, age = 12.0[5.6], 19% female), ADHD (n = 109, age = 11.1[4.1], 18% female), or OCD (n = 50, age = 12.3[4.2], 42% female), and typically developing controls (n = 65, age = 11.6[7.1], 48% female). The analyses revealed (1) associations with social communication abilities in distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, and (2) three data-driven, diagnosis-agnostic subgroups based on the patterns of association in the above networks. Our results suggest that different brain networks may contribute to social communication differences in subgroups that are not diagnosis-specific.
Alcohol Availability and Alcohol-Attributable Mortality: Economic Implications following a Change in Sales Policy
Authors: Stoppel Relika 
Published: May 2021

AbstractIt is commonly known that irresponsible alcohol use can have adverse effects. For some people, it results in health problems, for others in productivity loss, and some experience the worst possible outcome of alcohol misuse – death. This paper estimates the effect of reduced alcohol sales hours on alcohol-attributable mortality (AAM) in Estonia. Using novel mortality data from 1997 to 2015, this paper analyzes the effect of alcohol sales policies at both the county level and the country level. By applying the difference-in-differences method and the ARIMA model, this paper finds that the alcohol sales policy reduced AAM to between 1.710 and 2.401 deaths per 100,000 per month, which equals a reduction of 31% to 40% in AAM deaths. These findings suggest that individuals who are the most at risk of dying from alcohol-attributable causes of death benefit remarkably from reduced alcohol availability (JEL codes: I12, I18, and H75).
Rotavirus Vaccination Likely to Be Cost Saving to Society in the United States
Authors: Newall Anthony T , Leong Robert Neil , Reyes Josephine F , Curns Aaron T , Rudd Jessica , Tate Jacqueline , Macartney Kristine , Parashar Umesh 
Published: May 2021

Abstract

Background
Following the introduction of rotavirus immunization in 2006 in the United States, there were substantial declines in the domestic rotavirus disease burden. In this study, we assess the value for money achieved by the program in the decade following vaccine introduction.

Methods
We applied an age-specific, static, multicohort compartmental model to examine the impact and cost-effectiveness of the US rotavirus immunization program in children &lt;5 years of age using healthcare utilization data from 2001 to 2015 inclusive. We calculated the incremental cost-effectiveness ratio (ICER) per quality-adjusted life year (QALY) gained from both a healthcare system and societal perspective.

Results
Declines in healthcare use associated with the rotavirus and acute gastroenteritis occurred from 2006 and continued to grow before stabilizing from 2010 through 2011. From 2011 to 2015, an estimated annual average of approximately 118 000 hospitalizations, 86 000 emergency department presentations, and 460 000 outpatient and physician office visits were prevented. From a societal perspective during this same period, the program was estimated to be cost saving in the base case model and in &gt;90% of probabilistic sensitivity analysis simulations and from a healthcare system perspective &gt;98% of simulations found an ICER below $100 000 per QALY gained.

Conclusions
After the program stabilized, we found the rotavirus immunization in the United States was likely to have been cost saving to society. The greater than expected healthcare and productivity savings reflect the success of the rotavirus immunization program in the United States.