bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of housing policies on housing segregation in Indonesia
Authors: Wiranegara H W , Situmorang R , Safitri G , Dewi R C P , Maharaniputri S , Haridza T Q 
Published: April 2021

Abstract
Housing segregation has occurred in urban areas in Indonesia. Spatial segregation is shown by the phenomenon of gated community and social segregation is indicated by the absence of social relations among the groups. This housing segregation endangers the unity and integrity of the community. It is far from the ideal goal in housing development, i.e. to create harmonious community. This problem can be caused by the housing policies. Therefore, this study aims to identify housing policies that affect housing segregation in Indonesia. The methods used in this study were: 1) compose the conceptual framework of the emergence of segregation based on the results of the research article review; 2) collecting policy texts in the form of laws and regulations at the national level (constitution, government regulation, and ministerial regulation) for the past ten years; 3) review and map the contents of the policies following the conceptual framework; 4) analyze the mapping and look for policies relating to segregation. The results of the policy mapping show that although there are many policies to increase housing affordability and harmonious housing (diversity and balance), there is a clause in a balanced housing policy which states that the construction of simple housing for low-income groups may not be in the same location with the moderate and luxury housing has triggered the emergence of spatial segregation. Thus, it can be concluded that housing policy influences the occurrence of housing segregation in Indonesia.
Bacteriological air quality at transfer station area (case study: Gegerkalong Transfer Station, Bandung City)
Authors: Hasbiah A W , Nugroho F L , Juliana J 
Published: April 2021

Abstract
This study aims to measure air bacteriological concentration, to determine the effect of temperature, humidity, and wind speed on bacteriological concentration, and to identify the genus of bacteria found around Gegerkalong waste transfer station. Sampling of air bacteria at stations was based on a radius of 0, 10, 30 and 60 meters East, West, South and North of the transfer station at 09:00, 12:00 and 18:30 with 3 replicates. The method used to measure the concentration of air bacteria was the settling plate method. The results showed that maximum concentration of air bacteria found around the transfer station area was 67626 cfu/m3 and the minimum was 1153 cfu/m3 for agar nutrient media. Referring to the quality standards of the UK Environmental Agency, bacterial concentration in Gegerkalong waste transfer station exceeds the bacterial concentration standard of 1000 cfu/m3, whereas Coliform bacteria were below the standard. Bacteria found in the air around the transfer station are Pseudomonas, Klebsiella, Shigella, Alcaligenes, Salmonella, Escherichia, Bacillus, Staphyloococcus and Coliform. These can be concluded that a transfer station can be a source of airborne bacteria dispersion, which can have an impact on the surrounding community.
Effect of pH on metal mobility in the soil
Authors: Sintorini M M , Widyatmoko H , Sinaga E , Aliyah N 
Published: April 2021

Abstract
pH is a parameter that can be used to estimate the mobility of chemical elements in the soil and can be used to measure the level of toxicity and soil pollution. The purpose of this study is to prove how far the influence of pH on metal mobility in the soil. Method that used in this study, 35 samples each 1 kg were taken from the soil profile in Cilengsi Bogor and then dried at room temperature. From each sample 20 grams were taken for pH and Eh measurements. The result of this study that the analysis showed a significant correlation between pH and Eh with r = 0.888. Although the samples are heterogeneous or come from different soils, there is still a positive correlation between metal concentration and pH (pH-Mn = 0.12; pH-Cd = 0.0058; pH-Pb = 0.39). This means that for homogeneous samples, the correlation between pH-metals will be more significant. Eh and soil pH variations depends on the activity and decomposition of carbon by plants and microorganisms. Therefore, it can be ideally be concluded that the topsoil Eh is higher than the bottom Eh. The aerobic-anaerobic boundary is at around 300 mV.
Analysis of kitchen organic waste for processing using Black Soldier Flies in Kecamatan Cibiru, Bandung, West Java
Authors: Rochaeni A , Ismaria R , Fanira S 
Published: April 2021

Abstract
Black Soldier Flies (BSF) is a type of fly that is larger than ordinary flies and is famous for its ability to consume and reduce organic waste, especially kitchen organic waste (KOW). KOW processing using BSF will be carried out in Kecamatan Cibiru, Bandung City, so the characteristics of KOW produced by the community need to be analyzed. The number of samples is calculated based on SNI M 36-1991 on Method of Taking and Measuring Example of Formation and Composition of Municipal Waste, obtained 63 households, which are then divided into 3 income groups. Results show the average KOW generation in populations with high, medium and low incomes are 0.223, 0.153, and 0.103 kg/person/day, respectively. Based on the speed of consuming KOW by BSF where the composition of KOW is divided into 3 categories, the results are obtained that 47% KOW is consumed quickly, 29% KOW is consumed slowly, and 24% KOW is not consumed. It was also found that the high income population turned out to contribute the highest fast eaten KOW compared to the middle and low income population. This turned out to be influenced by cooking patterns and patterns of handling leftovers.
Information technology in monitoring the health of Stavropol State Agrarian University students in the environmental conditions
Authors: Tarasova S I , Dukhina T N , Limonova O O , Chudnova O A , Chvalun R V 
Published: April 2021

Abstract
The article discusses the features of the influence of the environmental situation on the state of human health. We revealed the necessity of monitoring students’ health with the use of information technologies as a factor influencing the training of future specialists and thereby improving the quality of education. The factors of optimization of the processes of preserving and strengthening the health of students of Stavropol State Agrarian University are determined. The tasks of the research are described, which consist in obtaining psychological information from monitoring the state of health of students, characterizing the educational process at the university, thereby ensuring the structuring of the system of psychological and pedagogical corrective measures.
Evaluation of the results of exploitation of directional wells in underground gas storage
Authors: Verzhbitsky V V , Gunkina T A , Verzhbitskaya V V , Khandzel A V , Prachev Y N 
Published: April 2021

Abstract
The article presents an assessment of the effective use of directional wells as a way to increase the productivity of underground gas storage. It analyzes the solutions to the problem of gas inflow to a horizontal well based on the use of a flat model of filtration flows. Evaluation of the efficiency of operation of directional (horizontal) wells was carried out using the example of the Kushchevsky underground gas storage.
Damage to the Vertical Braces of Industrial Buildings
Authors: Krahmalniy T A , Evtushenko S I 
Published: April 2021

Abstract
The article describes the types of vertical connections of industrial buildings, presents the results of surveys, describes typical defects: bends of the connecting grid, cutouts of elements, local bends and curvature of branches of connections, destruction of attachment points. The description of unique damages of vertical connections is given: cut branches of connections, fastening of connections to crane beams, change of the design decision of connection. In conclusion, the analysis of zones of formation of defects and grouping of defects by zones of formation is performed.
Perspective Directions of Renovation of Industrial Enterprises on the Example of Khabarovsk City
Authors: Putilov I D , Bazilevich M E 
Published: April 2021

Abstract
The article is devoted to the problems of renovation and functional re-profiling of industrial facilities of the Soviet industrialization period. On the example of the city of Khabarovsk, the possibility of revitalizing the territories of the Dalenergomash, Daldizel, Splav and Amurkabel factories, which at one time were the largest industrial enterprises in the region, is considered. An excursion into the history of these enterprises is given, their current state is considered, promising directions for the development of these objects and their territories are identified. Special attention is pays to the study of Russian and foreign experience in the renovation of industrial enterprises, which can be used in the Far East. As a result, the authors propose recommendations for possible renovation of industrial heritage sites in the city of Khabarovsk, taking into account the existing urban planning and economic situation.
Rheological Model of the Full Flow Curve of Highly Viscous and Solidifying Oil at Starting and Steady-State Mode Conditions
Authors: Karimov R M , Tashbulatov R R , Rabaev R U 
Published: April 2021

Abstract
The article is devoted to the need of taking into account the thixotropic properties of oils when oil pipeline starts after a long stop, as well as to calculation of the time of its safe stop. To evaluate the parameters of thixotropy, it is proposed to use the results of laboratory experiments of oil samples on a rotary viscometer. Typical properties of the rheological flow curves of thixotropic oils for the starting flow mode are determined. The use of the wave equation of damped vibrations is proposed to describe the rheological flow curve of the forward course of measurements of a rotational viscometer, characterized by the presence of ascents and descents of shear stresses. This equation, supplemented by a model of nonlinear-visco-plastic liquids, allows accurately finding the areas of appearance of thixotropic properties of oils. The article presents the results of experimental studies of the manifestation of thixotropic properties of two oil samples at a lower temperature. The wave equation of damped vibrations allows describing mathematically the ascents and descents of shear stresses observed at low oil temperatures. Experiments have shown that the wave properties of thixotropic oil do not change with a decrease in temperature except for the amplitude of maximum vibrations and are invariant properties of the studied liquid. The presented explanation of the physical mechanism for the manifestation of wave properties based on the hardening of the supramolecular paraffin crystal lattice characteristic of thixotropic oils explains the invariance of the frequency change function and the attenuation coefficient during starting processes at the beginning of the movement of the movable cylinder of a rotary viscometer. The result of laboratory studies allows determining the nature of changes in the contours of the zones of manifestation of thixotropic oil properties as a dependence on the temperature and shear rate.
A Machine Learning Model to Successfully Predict Future Diagnosis of Chronic Myelogenous Leukemia With Retrospective Electronic Health Records Data
Authors: Hauser Ronald G , Esserman Denise , Beste Lauren A , Ong Shawn Y , Colomb Denis G , Bhargava Ankur , Wadia Roxanne , Rose Michal G 
Published: April 2021

AbstractBackgroundChronic myelogenous leukemia (CML) is a clonal stem cell disorder accounting for 15% of adult leukemias. We aimed to determine if machine learning models could predict CML using blood cell counts prior to diagnosis.MethodsWe identified patients with a diagnostic test for CML (BCR-ABL1) and at least 6 consecutive prior years of differential blood cell counts between 1999 and 2020 in the largest integrated health care system in the United States. Blood cell counts from different time periods prior to CML diagnostic testing were used to train, validate, and test machine learning models.ResultsThe sample included 1,623 patients with BCR-ABL1 positivity rate 6.2%. The predictive ability of machine learning models improved when trained with blood cell counts closer to time of diagnosis: 2 to 5 years area under the curve (AUC), 0.59 to 0.67, 0.5 to 1 years AUC, 0.75 to 0.80, at diagnosis AUC, 0.87 to 0.92.ConclusionsBlood cell counts collected up to 5 years prior to diagnostic workup of CML successfully predicted the BCR-ABL1 test result. These findings suggest a machine learning model trained with blood cell counts could lead to diagnosis of CML earlier in the disease course compared to usual medical care.
Autogenous Fat Transplantation and Botulinum Toxin Injection Into the Masseter Muscle to Create an Ideal Oval Face
Authors: Zheng Zhifang , Hao Yongsheng , Yin Junfeiyang , Lei Xiaoxuan , Cheng Biao , Huang Wenhua 
Published: April 2021

Abstract

Background
East Asian faces vary in shape but only oval faces seem to be considered attractive. Many patients with wide faces seek removal of part of the mandibular angle and/or zygoma to achieve an ideal facial contour, but the procedure is high risk and the recovery period is relatively protracted.

Objectives
We sought to achieve ideal facial contours through the use of autologous fat grafting (AFG) combined with masseter botulinum toxin (BTX) injection for patients with wide faces and masseter hypertrophy.

Methods
Fourteen patients with wide faces underwent AFG of the forehead, temporal region, cheeks, zygomatic body, nose, nasolabial fold, tear trough, and chin; and BTX injection into the masseter muscles. Each patient was photographed more than 6 months after the operation. The pre- and postoperative ratios pertaining to the facial aesthetics of the face were calculated. The Hollowness Severity Rating Scale (HSRS) and Ricketts’s E-line were used to evaluate the photographs. Patient satisfaction was also investigated.

Results
All patients received AFG and 1 to 3 BTX injections. The face length:bizygomatic breadth, bigonial breadth:bizygomatic breadth, and lower-face height:middle-face height ratios improved greatly after treatment. The mean HSRS score decreased from 2.214 preoperatively to 1.071 postoperatively. The chin and nose became more prominent than before. Facial swelling persisted for an average of 11.929 days. All patients were satisfied with the treatment outcome.

Conclusions
A combination of AFG and BTX injection was able to achieve an ideal oval face in East Asian patients with wide faces and masseter hypertrophy, with very few complications. Recovery was rapid and patient satisfaction was high.

Level of Evidence: 4
Breast Implant–Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Are You Covered?
Authors: Ha Michael , Ngaage Ledibabari M , Zhu Kevin , Hricz Nicholas , Slezak Sheri , Rasko Yvonne M 
Published: April 2021

Abstract

Background
Breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a locally aggressive T-cell lymphoma that can develop following breast implantation. In 2017, and updated in 2019, the National Comprehensive Cancer Network (NCCN) recommended total capsulectomy with implant removal as definitive therapy.

Objectives
The aim of this study was to evaluate the US insurance coverage for the management of BIA-ALCL and compare it to the NCCN recommendations.

Methods
A cross-sectional analysis of US insurance policies for coverage of BIA-ALCL treatment was conducted. Insurance companies were selected based on their market share and state enrollment. Medical necessity criteria were abstracted from the publicly available policies.

Results
Of the 101 companies assessed, only 30 (30%) had a policy for the management of BIA-ALCL. Of those policies, all (n = 30, 100%) provided coverage of the implant removal of the breast diagnosed with BIA-ALCL. For the contralateral breast implant, 20 policies (67%) covered their removal, but significantly fewer did so if the implant was placed for cosmetic reasons vs medically necessary (n = 13 vs n = 20, 43% vs 67%; P = 0.0026). Twenty-one policies (70%) covered an implant reinsertion, but fewer would do so if the implant was cosmetic rather than medically necessary (n = 5, 17% vs 70%; P &lt; 0.0001).

Conclusions
There was notable intercompany variation in the coverage of BIA-ALCL treatment, some of which is unnecessarily based on whether the original reason for the breast implant was cosmetic or medically necessary. This variability may significantly reduce access to definitive treatment in patients with a BIA-ALCL diagnosis.
Aspiration Revisited: Prospective Evaluation of a Physiologically Pressurized Model With Animal Correlation and Broader Applicability to Filler Complications
Authors: Moon Hyoung-Jin , Lee Won , Kim Ji-Soo , Yang Eun-Jung , Sundaram Hema 
Published: April 2021

Abstract

Background
Aspiration testing before filler injection is controversial. Some believe that aspiration can help prevent inadvertent intravascular injection, whereas others cite false-negative results and question its value given that the needle position always changes somewhat during injection procedures.

Objectives
The authors sought to test the relation of false-negative results to the viscosity of the material within the needle lumen and determine whether a less viscous material within the needle lumen could decrease the incidence of false-negative results.

Methods
In vitro aspiration tests were performed utilizing 30-G and 27-G needle gauges, 2 cross-linked hyaluronic acid fillers, normal saline bags pressurized at 140 and 10 mmHg to mimic human arterial and venous pressures, and 3 needle lumen conditions (normal saline, air, and filler). Testing was repeated 3 times under each study condition (72 tests in total). For in vivo correlation, aspiration tests were performed on femoral arteries and central auricular veins in 3 rabbits (4–5 aspirations per site, 48 tests in total).

Results
In vitro and in vivo testing utilizing 30-G needles containing filler both showed false-negative results on aspiration testing. In vitro and in vivo testing utilizing needles containing saline or air showed positive findings.

Conclusions
False-negative results from aspiration testing may be reduced by pre-filling the needle lumen with saline rather than a filler. The pressurized system may help overcome challenges of animal models with intravascular pressures significantly different from those of humans. The adaptability of this system to mimic various vessel pressures may facilitate physiologically relevant studies of vascular complications.
Isolation and characterization of neuroprotective lignans from salted Aconiti lateralis Radix Praeparata
Authors: Ma Qinge , Chen Lihua , Wei Rongrui 
Published: April 2021

ABSTRACT
Six lignans (1-6) were isolated from salted Aconiti lateralis Radix Praeparata for the first time. These isolates were elucidated as hedyotisol-A (1), (7″R,8″R)-8″-syringaresinol-4″-hydroxy-3″,5″-dimethoxyphenyl-7″,9″-propanediol (2), lariciresinol-4-O-β-d-glucopyranoside (3),(7S,8S)-4-hydroxy-3-methoxy-7,8-(2′,1′-O-β-d-glucopyranosyl)phenyl-propanetriol (4), (+)-isolariciresinol (5), and (+)-lyoniresinol (6) by analyzing extensive and comprehensive spectral data and compared with the data described in the literature, respectively. Compounds (1-6) were evaluated for their neuroprotective activities against corticosterone-induced cell death in PC12 cells with desipramine as the positive control drug. Among them, compounds 1 and 2 showed moderate neuroprotective activities, which increased the survival rates of PC12 cells from 45.50 ± 2.23% to 65.98 ± 1.29%, 58.19 ± 2.94% at 10 µm, respectively.
MetaFusion: a high-confidence metacaller for filtering and prioritizing RNA-seq gene fusion candidates
Authors: Apostolides Michael , Jiang Yue , Husić Mia , Siddaway Robert , Hawkins Cynthia , Turinsky Andrei L , Brudno Michael , Ramani Arun K 
Published: April 2021

Abstract

Motivation
Current fusion detection tools use diverse calling approaches and provide varying results, making selection of the appropriate tool challenging. Ensemble fusion calling techniques appear promising; however, current options have limited accessibility and function.

Results
MetaFusion is a flexible metacalling tool that amalgamates outputs from any number of fusion callers. Individual caller results are standardized by conversion into the new file type Common Fusion Format. Calls are annotated, merged using graph clustering, filtered and ranked to provide a final output of high-confidence candidates. MetaFusion consistently achieves higher precision and recall than individual callers on real and simulated datasets, and reaches up to 100% precision, indicating that ensemble calling is imperative for high-confidence results. MetaFusion uses FusionAnnotator to annotate calls with information from cancer fusion databases and is provided with a Benchmarking Toolkit to calibrate new callers.

Availability and implementation
MetaFusion is freely available at https://github.com/ccmbioinfo/MetaFusion.

Supplementary information
Supplementary data are available at Bioinformatics online.
Extracellular histones are a target in myocardial ischaemia–reperfusion injury
Authors: Shah Mohammed , He Zhenhe , Rauf Ali , Beikoghli Kalkhoran Siavash , Heiestad Christina Mathisen , Stensløkken Kåre-Olav , Parish Christopher R , Soehnlein Oliver , Arjun Sapna , Davidson Sean M , Yellon Derek 
Published: April 2021

Abstract

Aims
Acute myocardial infarction causes lethal cardiomyocyte injury during ischaemia and reperfusion (I/R). Histones have been described as important Danger Associated Molecular Proteins (DAMPs) in sepsis. The objective of this study was to establish whether extracellular histone release contributes to myocardial infarction.

Methods and results
Isolated, perfused rat hearts were subject to I/R. Nucleosomes and histone-H4 release was detected early during reperfusion. Sodium-β-O-Methyl cellobioside sulfate (mCBS), a newly developed histone-neutralizing compound, significantly reduced infarct size whilst also reducing the detectable levels of histones. Histones were directly toxic to primary adult rat cardiomyocytes in vitro. This was prevented by mCBS or HIPe, a recently described, histone-H4 neutralizing peptide, but not by an inhibitor of TLR4, a receptor previously reported to be involved in DAMP-mediated cytotoxicity. Furthermore, TLR4-reporter HEK293 cells revealed that cytotoxicity of histone H4 was independent of TLR4 and NF-κB. In an in vivo rat model of I/R, HIPe significantly reduced infarct size.

Conclusion
Histones released from the myocardium are cytotoxic to cardiomyocytes, via a TLR4-independent mechanism. The targeting of extracellular histones provides a novel opportunity to limit cardiomyocyte death during I/R injury of the myocardium.