bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep pattern gender differences and fragmentation in postpartum parents of twins
Authors: Damato Elizabeth G , Burant Christopher J , Brubaker Jennifer A , Decker Michael J 
Published: December 2021

Objective Parents of newborn twins are at risk for both shortened sleep duration and sleep discontinuity. The purpose of this study was to characterize weekday and weekend sleep duration, sleep continuity, and awakenings in both mothers and fathers of newborn twins during the first 3 months at home.
Material and Methods Sleep-wake parameters were assessed at two time points using self-report diaries and actigraphy in 75 families with newborn twins. To assess sleep on weekdays and weekends with minimal subject burden, actigraphy recordings of both parents commenced at 9:00 p.m. Saturday and terminated at 9:00 p.m. Tuesday.
Results Mean sleep duration over 24 hours for parents of twins ranged between 6.7 and 7.5 hours during the first 3 months postpartum and did not significantly differ on weekdays or weekends for mothers. Weekend sleep was more fragmented for fathers at both one month and three months with more awakenings, compared to weekday sleep. Mothers had more fragmented night sleep compared to fathers at one month. In contrast, at three months postpartum fathers had shorter total sleep time and night sleep time, but fewer night awakenings on weekdays than mothers. No differences were observed in weekend sleep duration or sleep patterns between mothers and fathers at three months.
Discussion Consolidated sleep periods for both parents averages three hours or less during the first three months postpartum and sleep for both parents is fragmented. In families with newborn twins, the extent of sleep disruption for mothers and fathers is similar.
Integración de la tecnología digital en el aula: Diseño de una propuesta formativa online desde una mirada de la práctica reflexiva
Authors: Recio-Muñoz Francisco , Joo Nagata Jorge 
Published: December 2021

Ante la necesidad de crear espacios o contextos, tanto formales como informales, que supongan una conexión real del profesorado con su entorno, es que se presenta una propuesta de experiencia de aprendizaje diseñada para la Formación Inicial Docente (FID) sobre el pensamiento reflexivo, la integración de la tecnología digital en el aula y la Competencia Digital Docente (CDD) de estudiantes de Pedagogía en Chile. Dicha propuesta se centra en los círculos de reflexión pedagógica con el objetivo principal de explorar cómo se construye la práctica reflexiva durante las interacciones en línea, concretamente en sesiones asincrónicas por medio de foros de debate, a través del análisis del discurso del contenido generado en los mismos y si resulta ser una estrategia eficaz para el desarrollo de habilidades de pensamiento reflexivo al momento de analizar las prácticas docentes entorno a la integración de las tecnologías digitales en el aula. Encontrando preliminarmente cuatro categorías a la hora de justificar por parte del alumnado sobre qué definición de reflexión más se identifican. Y aludiendo a que cuando reflexionan sobre su quehacer docente al momento de integrar las tecnologías digitales en el aula lo hacen principalmente sobre las dimensiones del contenido y alumnado, siendo en menor medida el contexto sociopolítico.
Faced with the need to create spaces or contexts, both formal and informal, that involve a real connection between teachers and their environment, a proposal for a learning experience designed for Initial Teacher Training (ITT) on reflective thinking, integration of digital technology in the classroom and the Teaching Digital Competence (TDC) of Pedagogy students in Chile. This proposal focuses on pedagogical reflection circles with the main objective of exploring how reflective practice is built during online interactions, specifically asynchronous sessions through discussion forums, through the analysis of the discourse of the content generated in them. and if it turns out to be an effective strategy for the development of reflective thinking skills when analyzing teaching practices around the integration of digital technologies in the classroom. Preliminarily finding four categories when justifying by the students about which definition of reflection they most identify. And alluding to the fact that when they reflect on their teaching work when integrating digital technologies in the classroom, they do so mainly on the dimensions of the content and students, being to a lesser extent the socio-political context.
Ruang daring bercerita: Sebuah narasi tentang rute, navigasi, dan batas dalam arsitektur
Authors: Handayani Nina Dwi 
Published: December 2021

Kondisi pandemi yang membatasi pola pergerakan manusia atas ruang, di satu sisi menyebabkan manusia kehilangan makna dan rasa atas kehadiran ruang fisik, tapi di sisi lain memberikan peluang bagaimana cara memaknai ruang dengan cara yang berbeda. Instalasi Kisah Antah-berantah karya Citra Sasmita yang diinisiasi oleh Ruang Seni Anak Komisi UOB Museum MACAN, Jakarta ini berkisah tentang cerita fabel mitologis untuk anak-anak yang diinspirasi dari lukisan kamasan dan karakter cerita rakyat Tantri di Bali. Mempergunakan teknologi web-based augmented reality, Kisah Antah-berantah merupakan perpaduan objek seni dan ruang secara fisik dengan teknologi dunia maya, yang bisa dinikmati secara daring dan luring. Pengamatan karya instalasi Kisah Antah-berantah ini bertujuan untuk memperkaya gagasan atas keterlibatan rute, tur dan bagaimana memaknai batas pada ruang maya.
Pengamatan “mengalami ruang” secara daring oleh penulis dijelaskan melalui 2 cara yaitu mode operasi pasif 360˚ dan mode operasi aktif manual. Mode operasi pasif 360˚ menunjukkan bahwa dengan rute yang statis dan terukur, pengalaman memaknai ruang daring bercerita bisa tercapai, meskipun tidak memberikan pemahaman akan batas ruang yang baru. Sebaliknya dengan mode operasi manual aktif, dengan kebebasan rute yang dipilih dan diciptakan sendiri, pengunjung mampu menciptakan batas dan pemaknaan ruang baru yang berbeda. Dari kedua mode operasi ini, tanda (landmark) berupa titik kode optik hadir melampaui objek fisiknya sebagai bagian dari navigasi dalam ruang maya.

The pandemic condition that limits human movement over space has consequences that humans lose their meaning and sense of the presence of physical space, otherwise, it provides opportunities to interpret space differently. The installation Kisah Antah-berantah by Citra Sasmita, which was held during a pandemic and initiated by the Ruang Seni Anak Komisi UOB Museum MACAN, Jakarta tells the story of mythological fables for children inspired by kamasan paintings and Tantri folklore characters in Bali, Indonesia. Implementing web-based augmented reality technology, this installation has an equal collaboration of art objects and physical space which can be enjoyed virtually and in a real-time exhibition mode. Kisah Antah-berantah investigates ideas on the involvement of routes, tours, and how to define boundaries in architecture and virtual space.
The "experiencing space" will be explained in 2 ways, namely passive 360˚ operation mode and manual active operation mode. The 360˚ passive mode of operation shows that with a static and measurable route, the visitor interprets the virtual space of storytelling completely, although it does not provide a new understanding of spatial boundaries. In manual active of operation mode, visitors potentially create new boundaries and different meanings of space, by creating their routes. In these two modes of operations, an optical code point is presented as a landmark, as an important part of navigation in virtual space.
Hyperuricemia and Smoking Correlation in Egyptian Young Adults with Coronary Artery Disease: Observational Study
Authors: El-Sayed Youssef Ali Youssef , Badr Seham Fahmy , Abd El-Aal Mohamed Ahmed , El-Sheikh Ayman Ahmed 
Published: December 2021

Background: Young adults, especially those under 35, are often overlooked; however, previous studies have shown that coronary artery disease (CAD) incidence increases rapidly. Previous studies proved many risk factors for CAD, such as hyperlipidemia, hypertension, diabetes, and smoking. The present study ultimately aimed to figure out the correlation between Hyperuricemia (HUA) and smoking in CAD Patients under the age of 35.
Methods: This observational study included 100 young adults (18–35 years of age) suspected of CAD. We used the Gensini Score system to ascertain coronary angiography outcome and CAD; based on the number of affected vessels, localization of the segment, and the stenosis grade.
The Gensini score being > 0 indicated the presence of CAD.
Results: In young adults under 35, there was a significant correlation between HUA and CAD. The interaction between HUA and smoking had a contrast for CAD that statistically shown the existence of CAD increased in patients who have hyperuricemia and non-smokers compared to smokers.
Conclusions: By monitoring various parameters in young adults ≤ 35 years old. This study strengthens the correlation between:1) hyperuricemia and the occurrence of CAD, 2) Smoking and the CAD. Furthermore, there is a clear association between HUA and the occurrence of CAD in non-smokers.
Effect of Different Nutrient Management Practices on Productivity and Profitability of Double Zero Indian Mustard (Brassica juncea L.)
Authors: Indira Gajjela , Yadav R. B. , Vivek . , Naresh R. K. , Chandra M. Sharath , Chandrakanth Alladi , Shivangi . , Nath Ashish 
Published: December 2021

A field experiment was conducted at Crop Research Center, Sardar Vallabhbhai Patel University of Agriculture & Technology, Meerut, Uttar Pradesh in Rabi season 2021 with a view to compare the production potential under different nutrient management practices and also to find out the economic viability of this cultivar for soil quality. The experiment was analysed in Randomised block design (RBD) and the treatments comprised of Control (T1), 100% N (T2), 100% NP (T3), 100% NPK (T4), 125%NPK (T5), 100% NPK+ S@40kg ha-1 (T6), 100%NPK+ Zn@5kg ha-1 (T7), 100%NPK + B@1kg ha-1 (T8), 75% NPK+ VC@ 2t ha-1 (T9), 75%NPK+FYM@ 6t ha-1 (T10), 75%NPK + VC@ 2t ha-1+ Azotobacter (T11) and 75%.
NPK + FYM@6t ha-1 + Azotobacter (T12). Results revealed that treatment T11 and T12 exhibited significant influence on yield attributes and yields of mustard as compared to the application of 100% NPK alone. The maximum gross return was obtained in T12 followed by T11. The highest net return was obtained in T5 followed by T12, T6 and T11, whereas, minimum gross return and net return was obtained in T1.T11 recorded higher gross return and net return but the B:C ratio was lower due to higher cost of vermicompost. Higher values of B: C ratio (4.23) was obtained in T6 and T5 respectively. The current study reveals that T11 and T12 exhibited significant beneficial for yield, yield attributes and profitability of mustard.
Nocturnal Enuresis in Primary Schools Children (6-12 Years) of Tabuk City, Saudi Arabia
Authors: Alomani Omaima Tawfiq , Khalil Tahani 
Published: December 2021

Background: Regardless of the significance and the disturbing magnitudes of NE, this problem remains under-reported in Tabuk, Saudi Arabia and comprehensive studies in this regard are considerably lacking in that region. This study aimed to discuss the prevalence and associated risk factors of NE among children in Saudi Arabia.
Methodology: A cross sectional study design was adopted in Tabuk, KSA using a self-administered questionnaire for data collection distributed online on social media sites to be filled out personally. All data were collected, tabulated, and statistically analyzed using SPSS 23.0 for windows (SPSS Inc., Chicago, IL, USA).
Results: The study included 431 participants. (37.4%) of children aged between six and seven years old, (32.7%) between eight and nine years old, and (17.2%) between ten and twelve years old. (58.9%) of children were males and (41.1%) females. Average frequency various from (53.8%) one time to two times per week, (31.3%) three times to four times per week, (14.8% five times to seven times per week. Enuresis was at night only in (77.5%) while (22.5%) at day or night. (64.5%) don’t seek to medical advice, while (35.5%) getting medical advice. (48.5%) of children getting behavioral therapy to treat this condition, (15.8%) exercise to strengthen bladder muscles, (14.6%) getting medical treatment, (10%) getting urination alarm, (0.5%) doing surgical intervention. There was a significant relationship between frequency per week of enuresis with mother educational level, number of family member, age of child (6-7) years old, sex of child (female), family history of nocturnal enuresis and delayed growth. Also, there was a significant relation between timing of enuresis during night or day and night with parents suffering from nocturnal enuresis, father’s education level, mother’s education level, and caring of parents to awaken the child.
Conclusion: Nocturnal enuresis associated factors and parenteral knowledge of definition and causes of it were among universal reported figures. Referral to a pediatric urologist can be indicated for children with primary enuresis refractory to standard and combination therapies, and for children with some secondary causes of enuresis, including urinary tract malformations, recurrent urinary tract infections, or neurologic disorders.
Formulation Development and Evaluation of Migraine Almotriptan Loaded Ethosomes Using Box Behnken Design
Authors: Parashar Megha , Jain Ashish 
Published: December 2021

One of the most common nervous system illnesses is headache disorders, which are characterized by chronic headaches. In Present investigation Almotriptan loaded Ethosomes were prepared by water phase addition method. The three independent factors including Phosphotidylcholine: Cholestrol: DSPE (6:3:1molar ratio), Surfactant concentration and sonication time. A factorial design 3*3(3 factor 3 level) was applied to prepare 17 formulation. Optimization of ethosomal preparation was carried out by applying Box Behnken response surface randomized factorial design following quadratic model using Design of Experiment (DOE) software version 11.04.0. The factor Soya PC: Cholesterol: DSPE in molar ration (6:3:1), Concentration of Tween-80 and sonication time were selected as dependable process and formulation factors that can be effect formulation characteristics like entrapment efficiency, average vesicle size, Polydispersity Index (PDI). All other factors like sonication speed and rotation speed was kept constant All the formulation were prepared by simple solvent evaporation thin film formation method and characterized for the drug entrapment, average vesicle size and PDI, shape morphology. Formulations were optimized on the basis of responses such as average vesicle size, PDI, and entrapment efficiency. All the characterized values of the responses were putted in the formulation design table and analyse to best fitted model for the design. It was observed that, quadaratic model is best fitted model for the design. The prepared ethosomes formulation can further incorporated in situ gel for effective treatment of migraine.
Report of a recent examination of the Roman Camp at Cleghorn, Lanarkshire, styled 'Agricola's Camp;' with Notices of General Roy and his Family
Authors: Rankin D R 
Published: December 2021

The author has issued a correction to the publication Caledonia Romana by Robert Stuart (1845). Stuart's publication claims that Agricola's camp near Cleghorn is on the right of the road to Edinburgh and that only one part of its ramparts remains visible. However, according to Rankin, this camp is on the left of the road and is mostly in tact. He relates a description of the current state of the camps at Cleghorn and Castledykes with regerence to General Roy's plans from 1753 an 1764. Rankin then finishes with a brief overview of General Roy's early life in Carluke.

Meetings minutes for 14 March 1853 are appended.
On some suggestive examples of Abortive Discovery in Ancient Art
Authors: - - , Wilson Daniel 
Published: December 2021

The final conversazione of this session was held in the Society's rooms on 26 April 1853.

Dr Daniel Wilson delivered a lecture on brass engravings. He argues that the Society's collection of ancient art can be viewed as examples of early engraved printing plates (chalcographic art). He discusses examples from throughout antiquity and the medieval period, referencing brass engravings from Europe, Africa and Asia. He notes that although ancient engraved pieces could be used to create printed artwork, they were not used for this purpose because of how delicate and valuable they were. He also touches on other forms of engraving including wood engraving, seal and gem engraving, engraved personal ornaments, and the use of engraving in creating materials for printing presses or coin mints. He concludes with examples of engraved items found in Scotland on both Roman and church sites.

The meeting notes for 9 May 1853 are appended.
An attempt to define how far the cymric encroached upon the Gaelic Branch of the early Celtic population of North Britain
Authors: Rhind Alexander Henry 
Published: December 2021

The author presents his argument regarding the extent of Brittonic territory in Roman-age Scotland. He compares the names of tribes recorded in Ptolemy's Geography to similar tribal names recorded in southern parts of Britain and concludes that there is significant overlap for tribal names in the central belt, as well as the areas that are now Fife, Perthshire and Angus. He also supports his argument with evidence from contemporary place-names, particularly the use of the prefix 'aber', that he argues is imported from Brittonic areas such as Wales rather than Gaelic-speaking Ireland. Rhind summarises his argument through using tables and lists at the end of the article.

Meeting notes for the meeting held 13 June 1853 are appended.
Suggestions for a National Exhibition of Scottish Portraits in Edinburgh, in the year 1855; including a communication on the subject from Thomas Carlyle
Authors: Laing David 
Published: December 2021

Secretary David Laing returned to the proposal for a National Portrait Gallery of Scotland. He presented a letter from historian and essayist Thomas Carlyle on the subject. Carlyle highlights the importance of portraiture for encouraging an interest in history, as well as the artistic value of displaying portraits. He makes the point that the selection of whose portraits to include will be key to the success of the gallery. He ends his letter with some recommendations on how the gallery should be created and run. David Laing then requests that this idea be put before the Board of Trustees again and suggests that a committee should be formed to make enquiries about portraits that might be included. His proposals were approved by the members.

Meeting notes for 10 July, 1854 are appended.
Anniversary Meeting
Authors: - - 
Published: December 2021

After covering the resignation of the previous year's Secretary and Museum Curator, the Vice-President then commemorated the Fellows who died in the preceding year. It was noted that there were more than twice the number of visitors to the Museum in the past year, after changes were made to the regulations to allow the public to be admitted.

Meeting minutes for the meeting held December 11, 1854 are appended.
Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery
Authors: Lin Long , Wang Yuqiong , Cai Minkun , Jiang Xinran , Hu Yongyan , Dong Zaizai , Yin Dedong , Liu Yilin , Yang Shaohua , Liu Zhiguang , Zhuang Jian , Xu Ye , Guo Chuan Fei , Chang Lingqian 
Published: December 2021

AbstractCommon delivery routes for chemotherapeutics are based on circulation, which faces clinical limitations to local delivery efficiency, and the conflict between the dose for anticancer effect and the systemic toxicity. The recent advances in localized delivery strategies aim to improve drug accumulation at the target site or directly transport into cells. However, most are not equipped to provide additional momentum in the process of cargo release, propagation, and intracellular movement, which limit their locomotion that relies on passive diffusion. In this work, a multimicrochannel microneedle microporation (4M) platform that achieves high efficiency, safety, and uniformity for in vivo intracellular delivery is proposed. By high precision 3D printing, internal microchannels are implemented through the microneedle, which offer a concentrated, safe electric field that not only accelerates the movement of cargo into deep tissue under electrophoresis, but also triggers cell electroporation, achieving enhanced transport across cell membrane. The platform proves efficient for the delivery of chemotherapeutics in solid tumors in vitro and in vivo, with significantly enhanced anticancer effect and reduced systemic toxicity. The platform serves as a general‐purpose delivery tool to emerging drugs in vivo.
d‐Amino Acid‐Based Metabolic Labeling Enables a Fast Antibiotic Susceptibility Test of Both Isolated Bacteria and Bronchoalveolar Lavage Fluid
Authors: Gao Juan , Guo Junnan , Chen Jianxiao , Ding Chenling , Wang Jiemin , Huang Qian , Jian Ying , Zhao Xianyuan , Li Min , Gao Yuan , Yang Chaoyong , Wang Wei 
Published: December 2021

AbstractThe threat of multidrug‐resistant bacteria has escalated rapidly, increasing the demand for accurate antibiotic susceptibility tests (ASTs). Traditional bacterial growth yield‐based ASTs often take overnight to report, delaying the timely guidance of antibiotic use. Here, a fluorescent d‐amino acid (FDAA) labeling‐based AST (FaAST) is reported, which can quickly provide accurate minimum inhibitory concentrations (MICs). The FDAA‐labeling signals that reflect the bacterial metabolic status underlie the flow cytometry‐based strategy for MIC determination. Resistant bacteria show a reluctant decline in FDAA‐labeling (inhibited metabolism) after treatment with the corresponding antibiotics, whereas susceptible bacteria demonstrate quick responses to low doses of drugs. The MICs are determined based on the changing trends in labeling. After testing 23 clinical isolates and laboratory strains of the most critical drug‐resistant bacteria against a panel of representative antibiotics, FaAST shows a high susceptibility category with an accuracy of 98.13%. Moreover, FaAST can also make quick and accurate diagnosis against bronchoalveolar lavage fluids collected from hospital‐acquired pneumonia patients, saving 2–4 days in guiding antibiotic use for this life‐threatening infection. Thus, the speed, accuracy, and broad applicability of FaAST will be valuable in informing antibiotic decisions when treating critical infections caused by drug‐resistant bacteria.