bluuebunny/crossref_metadata_2025_split huggingface dataset:
O Programa de Residência Pedagógica: Interface entre o conhecimento pedagógico e experiencial?
Authors: Tavares Andrezza Maria Batista do Nascimento , Lopes Rayssa Cyntia Baracho , Silva José Moisés Nunes da 
Published: January 2021

Neste estudo, abordaremos a temática relacionada ao Programa de Residência Pedagógica (PRP), a partir do questionamento: interface entre o conhecimento pedagógico e experiencial? Para tanto, temos como objetivo de pesquisa refletir sobre a relação que o Programa de Residência Pedagógica estabelece entre a formação profissional dos licenciandos e a aquisição do conhecimento experiencial da docência. No que concerne à metodologia, a pesquisa é de natureza qualitativa, subsidiada por revisão bibliográfica, com base nas proposições de Nóvoa, Tardif, Charlot e Imbernón, dentre outros, e análise documental, tendo como fontes leis, pareceres e o Edital CAPES PRP nº 06/2018. Diante do exposto, como resultados, o estudo sinaliza que o PRP compreende ciclos de formação inicial relevantes a partir da imersão direta de residentes no locus da profissão docente, estimulando a produção do conhecimento experiencial e a vivência de dinâmicas que impulsionam o desenvolvimento humano e o trabalho docente para a escola transformadora.
Phenotypic differentiation of patients with chronic heart failure
Authors: Voronina L. P. , Polunina O. S. , Bashkina O. A. , Polunina E. A. , Prokofieva T. V. 
Published: January 2021

Objective. According to the results of a complex analysis of gender-anamnestic, clinical, biochemical and instrumental parameters using the cluster analysis method to identify phenotypes of chronic heart failure (CHF) in the examined patients.Materials and methods. It was examined 345 patients with CHF with different left ventricular ejection fraction and 60 somatically healthy volunteers. For the study, groups of indicators were formed that most widely characterize the pathogenesis of CHF: gender-anamnestic and clinical, instrumental (echocardiographic study, study of the functional state of the vascular endothelium and skin microcirculation, calculation of the volume fraction of interstitial collagen), biochemical parameters of the functional state of the vascular endothelium, collagen balance, inflammation and oxidative stress.Results. After the cluster analysis by the methods of hierarchical classification and k-means, we identified 4 clusters/phenotypes of CHF: fibrous-rigid, fibrous-inflammatory, inflammatory-destructive and dilatation-maladaptive. According to the results of the analysis of variance were identified 27 of the 48 indicators in which the level of statistical significance of intergroup differences (for the Fisher test) was less than 0.05, that is, indicators that make the greatest contribution to the division of patients with CHF into phenotypic groups.Conclusion. Our analysis with the release of phenotypes indicates that patients with CHF with different phenotypes have clinical and pathogenetic features. The data obtained in the future can be used to determine the prognosis of the disease and the choice of tactics for the management and treatment of patients with CHF depending on the phenotype.
Control of the emission of elementary quantum systems using metamaterials and nanometaparticles
Authors: Klimov V V 
Published: January 2021

Abstract
The most important direction in the development of fundamental and applied physics is the study of the properties of optical systems at nanoscales for creating optical and quantum computers, biosensors, single-photon sources for quantum informatics, DNA sequencing devices, detectors of various fields, etc. In all these cases, nanosize light sources such as dye molecules, quantum dots (epitaxial or colloidal), color centers in crystals, and nanocontacts in metals are of utmost importance. In the nanoenvironment, the characteristics of these elementary quantum systems—pumping rates, radiative and nonradiative decay rates, the local density of states, lifetimes, level shifts—experience changes, which can be used to create nanosize light sources with the desired properties. Modern theoretical and experimental works on controlling the emission of elementary quantum systems with the help of plasmonic and dielectric nanostructures, metamaterials, and metamaterial nanoparticles are analyzed.
Intraseasonal Variability of the East Asia-Pacific Teleconnection and Its Impacts on Multiple Tropical Cyclone Genesis Over the Western North Pacific
Authors: Lin Xin , Wang Lan , Gao Jianyun , Chen Xiaoxiao , Zhang Wei 
Published: January 2021

A daily East Asia–Pacific teleconnection (EAP) index was constructed to investigate the impact of the intraseasonal variability (ISV) of this index on the genesis of multiple tropical cyclones (MTC) in boreal summer over the western North Pacific (WNP). The result indicates that the EAP index has dominant intraseasonal periods of 10–20 days, 20–40 days and 50–70 days, respectively. The ISV of the EAP during 1979–2019 can be classified into three types, a single-period-domination type (37%), a multiple period coexistence type (24%) and a transition type (39%). It is found that during El Niño (La Niña) summers, the ISV of the EAP is dominated by a higher-frequency (lower-frequency) oscillation with a period of around 20–30 (50–70) days. The distinctive ISV characteristics during the different ENSO years were accompanied with different dynamic and thermodynamic background conditions over the WNP and the South China Sea, which modulated the frequency and location of MTC genesis. By examining the relative contributions of individual environmental variables of the Genesis Potential Index, we found that the low-level absolute vorticity and mid-level relative humidity are two important environmental factors modulating MTC genesis. However, the relative role of these variables tends to change with the EAP ISV phase. The environmental condition over the SCS appears less influenced by ENSO. A more southern location of MTC genesis during El Niño is attributed to the change of the environmental humidity.
Short-Term Monitoring of Geogenic Soil CO2 Flux in a Non-Volcanic and Seismically Inactive Emission Site, South Korea
Authors: Kim Chan Yeong , Yu Soonyoung , Oh Yun-Yeong , Chae Gitak , Yun Seong-Taek , Shinn Young Jae 
Published: January 2021

Temporal changes of soil CO2 flux (FCO2) and soil CO2 concentration ([CO2]v) were surveyed in a natural CO2 emission site to characterize the factors controlling the short-term temporal variation of geogenic FCO2 in a non-volcanic and seismically inactive area. Due to a lack of long-term monitoring system, FCO2 was discontinuously measured for three periods: Ⅰ, Ⅱ at a high FCO2 point (M17) and Ⅲ about 30 cm away. Whereas [CO2]v was investigated at a point (60 cm depth) for all periods. A 2.1 magnitude earthquake occurred 7.8 km away and 20 km deep approximately 12 h before the period Ⅱ. The negative correlation of FCO2 with air pressure suggested the non-negligible advective transport of soil CO2. However, FCO2 was significantly and positively related with air temperature as well, and [CO2]v showed different temporal changes from FCO2. These results indicate the diffusive transport of soil CO2 dominant in the vadose zone, while the advection near the surface. Meanwhile [CO2]v rapidly decreased while an anomalous FCO2 peak was observed during the period Ⅱ, and the CO2 emission enhanced by the earthquake was discussed as a possible reason for the synchronous decrease in [CO2]v and increase in FCO2. In contrast, [CO2]v increased to 56.8% during the period Ⅲ probably due to low gas diffusion at cold weather. In addition, FCO2 was low during the period Ⅲ and showed different correlations with measurements compared to FCO2 at M17, implying heterogeneous CO2 transport conditions at the centimeter scale. The abnormal FCO2 observed after the earthquake in a seismically inactive area implies that the global natural CO2 emission may be higher than the previous estimation. The study result suggests a permanent FCO2 monitoring station in tectonically stable regions to confirm the impact of geogenic CO2 to climate change and its relation with earthquakes.
Case Report: Glucocorticoids Combined With Immunosuppressant in the Treatment of Acromegaly Complicated With Focal Segmental Glomerulosclerosis
Authors: Wang Ruiqiang , Wu Yunqi , An Dongyue , Ma Pupu , Guo Yuanyuan , Tang Lin 
Published: January 2021

Background: Acromegaly is a chronic disease caused by excessive secretion of growth hormone (GH), which circulates and stimulates the liver and body tissues to produce insulin-like growth factor type 1 (IGF-1). Experimental studies have shown that excessive secretion of GH is related to glomerular sclerosis, and elevated IGF-1 levels may be involved in the occurrence of glomerular hypertrophy. But relevant clinical cases are rare. Here, we reported a case of acromegaly complicated with focal segmental glomerulosclerosis (FSGS).Case Presentation: A 49-year-old man was admitted to our hospital because of acromegaly for more than 10 years and proteinuria for more than 3 years. Acromegaly was confirmed by contrast-enhanced magnetic resonance imaging, minimally invasive surgery and pathology. The results of renal biopsy showed FSGS-NOS (not otherwise specified) with ischemic renal injury and mesangial IgA deposition. One month after transnasal transsphenoidal space occupying resection, GH and urinary protein decreased significantly, and nephropathy was partially relieved. In the next 4 months, GH stabilized at the normal level, while urinary protein gradually increased. When the urinary protein increased to 4.2 g/d, the dosage of glucocorticoids increased to 20 mg/d, and tacrolimus 1 mg/d were added, and the urinary protein decreased again. However, when the urinary protein decreased to 0.43 g/d, the patient stopped taking glucocorticoids and tacrolimus, and the urinary protein increased to 2.85 g/d after 8 months, but the GH was still in the normal range.Conclusion: In this case, GH is partially involved in the formation of FSGS. Not only does surgery reduce the effects of GH, but low doses of glucocorticoids and immunosuppressant are effective in slowing the progression of kidney disease, at least in reducing urinary protein.
Efficacy and Safety of TACE Combined With Sorafenib Plus Immune Checkpoint Inhibitors for the Treatment of Intermediate and Advanced TACE-Refractory Hepatocellular Carcinoma: A Retrospective Study
Authors: Zheng Liyun , Fang Shiji , Wu Fazong , Chen Weiqian , Chen Minjiang , Weng Qiaoyou , Wu Xulu , Song Jingjing , Zhao Zhongwei , Ji Jiansong 
Published: January 2021

Purpose: The study aims to retrospectively investigate the efficacy and safety of sorafenib combined with transarterial chemoembolization (TACE) (TACE+Sor) vs. TACE combined with sorafenib plus immune checkpoint inhibitors (TACE+Sor+ICIs) in treating intermediate and advanced TACE-refractory hepatocellular carcinoma (HCC).Materials and Methods: This study was approved by the ethics committee of Lisui Hospital, Zhejiang University, China. From January 2016 to June 2020, 51 eligible patients with intermediate or advanced TACE-refractory HCC received TACE+Sor (n = 29) or TACE+Sor+ICIs (n = 22). The differences in tumor response, adverse events (AEs), progression-free survival (PFS), and overall survival (OS) were compared between the two groups. Factors affecting PFS and OS were determined by Cox regression.Results: The disease control rate was higher in the TACE+Sor+ICIs group than in the TACE+Sor group (81.82 vs. 55.17%, P = 0.046). Compared with the TACE+Sor group, PFS and OS were prolonged in the TACE+Sor+ICIs group (median PFS: 16.26 vs. 7.30 months, P &lt; 0.001; median OS: 23.3 vs. 13.8 months, P = 0.012). Multivariate analysis showed that BCLC stage, alpha-fetoprotein and treatment were independent factors of PFS; BCLC, Child-Pugh class, ablation after disease progression and treatment were independent predictive factors of OS. Four patients in the TACE+Sor+ICIs group and three patients in the TACE+Sor group suffered from dose reduction or interruption (18.18 vs. 10.34%, P = 0.421). The incidence of ICI-related AEs in the TACE+Sor+ICIs group was well-controlled.Conclusion: The therapeutic schedule of TACE+Sor+ICIs demonstrated efficacy and safety in intermediate and advanced TACE-refractory HCC.
A Novel INCNS Score for Prediction of Mortality and Functional Outcome of Comatose Patients
Authors: Zhao Zhihan , Zhang Xiao , Song Changgeng , Zhao Jingjing , Gao Qiong , Jiang Wen 
Published: January 2021

Objectives: The purpose of this study was to verify the veracity and reliability of the INCNS score for prediction of neurological ICU (NICU) mortality and 3-month functional outcome and mortality in comatose patients.Methods: In this prospective study, data of the patients admitted to NICU from January 2013 to January 2019 were collected for validation. The 3-month functional outcomes were evaluated using modified Rankin Scale (mRS). By using the receiver operating characteristics curve (ROC) analysis, we compared the INCNS score with Glasgow Coma Scale (GCS), Full Outline of Un-Responsiveness Score (FOUR) and Acute Physiology and Chronic Health Evaluation II (APACHE II) for assessment of the predictive performance of these scales for 3-month functional outcome and mortality and NICU mortality performed at 24- and 72-h after admission to the NICU.Results: Totally 271 patients were used for evaluation; the INCNS score achieved an AUC (area under the receiver operating characteristic curve) of 0.766 (95% CI: 0.711–0.815) and 0.824 (95% CI: 0.774–0.868) for unfavorable functional outcomes, an AUC of 0.848 (95% CI: 0.800–0.889) and 0.892 (95% CI: 0.848–0.926) for NICU mortality, and an AUC of 0.811 (95% CI: 0.760–0.856) and 0.832 (95% CI: 0.782–0.874) for the 3-month mortality after discharge from the NICU at 24- and 72-h. The INCNS score exhibited a significantly better predictive performance of mortality and 3-month functional outcomes than FOUR and GCS. There was no significant difference in predicting NICU mortality and 3-month functional outcomes between INCNS and APACHE II, but INCNS had better predictive performance of 3-month mortality than APACHE II.Conclusions: The INCNS score could be used for predicting the functional outcomes and mortality rate of comatose patients.
Olfactory Cues in Infant Feeds: Volatile Profiles of Different Milks Fed to Preterm Infants
Authors: Muelbert Mariana , Bloomfield Frank H. , Pundir Shikha , Harding Jane E. , Pook Chris 
Published: January 2021

Background: Smell is determined by odor-active volatile compounds that bind to specific olfactory receptors, allowing us to discriminate different smells. Olfactory stimulation may assist with digestion and metabolism of feeds in the neonate by activation of the cephalic phase response of digestion. Infants' physiological responses to the smell of different milks suggest they can distinguish between breastmilk and infant formula. We aimed to describe the profile of volatile compounds in preterm breastmilk and investigate how this differed from that of other preterm infant feeding options including pasteurized donor breastmilk, breastmilk with bovine milk-based fortifier, human milk-based products and various infant formulas.Methods: Forty-seven milk samples (13 different infant formulas and 34 human milk-based samples) were analyzed. Volatile compounds were extracted using Solid Phase Micro Extraction. Identification and relative quantification were carried out by Gas Chromatography with Mass Spectrometry. Principal Component Analysis (PCA) and one-way Analysis of Variance (ANOVA) with Tukey's HSD (parametric data) or Conover's post-hoc test (non-parametric data) were used as appropriate to explore differences in volatile profiles among milk types.Results: In total, 122 compounds were identified. Breastmilk containing bovine milk-based fortifier presented the highest number of compounds (109) and liquid formula the lowest (70). The profile of volatile compounds varied with 51 compounds significantly different (adjusted p &lt; 0.001) among milk types. PCA explained 47% of variability. Compared to preterm breastmilk, the profile of volatile compounds in breastmilk with added bovine milk-based fortifier was marked by presence of fatty acids and their esters, ketones and aldehydes; infant formulas were characterized by alkyls, aldehydes and furans, and human milk-based products presented high concentrations of aromatic hydrocarbons, terpenoids and specific fatty acids.Conclusions: Sensory-active products of fatty acid oxidation are the major contributors to olfactory cues in infant feeds. Analysis of volatile compounds might be useful for monitoring quality of milk and detection of oxidation products and environmental contaminants. Further research is needed to determine whether these different volatile compounds have biological or physiological effects in nutrition of preterm infants.
Malignant Progression Contributes to the Failure of Combination Therapy for Atypical Meningiomas
Authors: Zhang Qing , Wen Zheng , Ni Ming , Li Da , Wang Ke , Jia Gui-Jun , Wu Zhen , Zhang Li-Wei , Jia Wang , Wang Liang , Zhang Jun-Ting 
Published: January 2021

ObjectiveTo investigate the independent risk factors for recurrence in intracranial atypical meningiomas (AMs) treated with gross total resection (GTR) and early external beam radiotherapy (EBRT).MethodsClinical, radiological, and pathological data of intracranial AMs treated with GTR-plus-early-EBRT between January 2008 and July 2016 were reviewed. Immunohistochemical staining for Ki-67 was performed. Kaplan–Meier curves and univariate and multivariate Cox proportional hazards regression analyses were used to explore independent predictors of tumor recurrence. Chi square test was performed to compare variables between subgroups.ResultsForty-six patients with intracranial AMs underwent GTR and early EBRT. Ten (21.7%) recurred and three (6.5%) died during a median follow-up of 76.00 months. Univariate and multivariate Cox analyses revealed that malignant progression (MP) (P = 0.009) was the only independent predictor for recurrence, while Ki-67 was of minor value in this aspect (P = 0.362). MP-AMs had a significantly higher recurrence rate (P = 0.008), a higher proportion of irregularly shaped tumors (P = 0.013) and significantly lower preoperative Karnofsky Performance Scale (KPS) scores (P = 0.040) than primary (Pri) AMs. No significant difference in Ki-67 expression was detected between these subgroups (P = 0.713).ConclusionsMP was significantly correlated with an increased incidence of recurrence in GTR-plus-early-EBRT-treated intracranial AMs. Significantly higher frequencies of tumor relapse and irregularly shaped tumors and lower preoperative KPS scores were observed in MP-AMs compared with Pri-AMs. Ki-67 expression is of minor value in predicting tumor recurrence or distinguishing tumor origins in AMs.
Prognostic Analysis and Influencing Serum Biomarkers of Patients With Resectable Pancreatic Adenosquamous Cancer
Authors: Shi Yusheng , Wang Xinjing , Wu Weize , Xie Junjie , Jin Jiabin , Peng Chenghong , Deng Xiaxing , Chen Hao , Shen Baiyong 
Published: January 2021

ObjectivesThere are few reports about the survival rate of patients with pancreatic adenosquamous cancer (PASC). This study evaluated and analyzed prognostic factors of patients with resectable pancreatic adenosquamous cancer (rPASC), which might fulfill the blank in the research of PASC.MethodsIn this study, we identified and analyzed 55 patients who were diagnosed with rPASC from January 2013 to May 2019 at the Pancreatic Disease Center of the Shanghai Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine. Age, sex, BMI, tumor position, and other important demographic data were collected and analyzed. The follow-up was updated by December 31th, 2019 with a median follow-up of nine months.ResultsAmong the 55 patients, 23 (41.8%) patients were female, and the mean age was 62.0 ± 10.3 years. The median overall survival (OS) time was 10 ± 2.1 months, and the median disease-free survival (DFS) time was 4 ± 0.9 months. The 1-year, 3-year, and 5-year survival rates were 40.9, 17.5, and 11.6%, respectively. The multivariate analysis showed that normal serum level of Ca199 (HR = 0.464, 95% CI = 0.222–0.970, P = 0.041) and Ca125 (HR = 0.441, 95% CI = 0.233–0.835, P = 0.012) were independent favorable prognostic factors.ConclusionPatients with rPASC had poor survival. The 5-year survival rate was only 11.6%. Normal serum levels of Ca199 and Ca125 were independent favorable prognostic factors that predicted prognosis.
Isoprostanes as Biomarker for White Matter Injury in Extremely Preterm Infants
Authors: Coviello Caterina , Perrone Serafina , Buonocore Giuseppe , Negro Simona , Longini Mariangela , Dani Carlo , de Vries Linda S. , Groenendaal Floris , Vijlbrief Daniel C. , Benders Manon J. N. L. , Tataranno Maria Luisa 
Published: January 2021

Background and Aim: Preterm white matter is vulnerable to lipid peroxidation-mediated injury. F2-isoprostanes (IPs), are a useful biomarker for lipid peroxidation. Aim was to assess the association between early peri-postnatal IPs, white matter injury (WMI) at term equivalent age (TEA), and neurodevelopmental outcome in preterm infants.Methods: Infants with a gestational age (GA) below 28 weeks who had an MRI at TEA were included. IPs were measured in cord blood (cb) at birth and on plasma (pl) between 24 and 48 h after birth. WMI was assessed using Woodward MRI scoring system. Multiple regression analyses were performed to assess the association between IPs with WMI and then with BSITD-III scores at 24 months corrected age (CA). Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of pl-IPs for the development of WMI.Results: Forty-four patients were included. cb-IPs were not correlated with WMI score at TEA, whereas higher pl-IPs and lower GA predicted higher WMI score (p = 0.037 and 0.006, respectively) after controlling for GA, FiO2 at sampling and severity of IVH. The area under the curve was 0.72 (CI 95% = 0.51–0.92). The pl-IPs levels plotted curve indicated that 31.8 pg/ml had the best predictive threshold with a sensitivity of 86% and a specificity of 60%, to discriminate newborns with any WMI from newborns without WMI. IPs were not associated with outcome at 24 months.Conclusion: Early measurement of pl-IPs may help discriminate patients showing abnormal WMI score at TEA, thus representing an early biomarker to identify newborns at risk for brain injury.