bluuebunny/crossref_metadata_2025_split huggingface dataset:
The local wave phenomenon in the quintic nonlinear Schrödinger equation by numerical methods
Authors: Tang Yaning , Liang Zaijun , Xie Wenxian 
Published: August 2021

Abstract
The nonlinear Schrodinger hierarchy has a wide range of applications in modeling the propagation of light pulses in optical fibers. In this paper, we focus on the integrable nonlinear Schrodinger (NLS) equation with quintic terms, which play a prominent role when the pulse duration is very short. First, we investigate the spectral signatures of the spatial Lax pair with distinct analytical solutions and their periodized wavetrains by Fourier oscillatory method. Then, we numerically simulate the wave evolution of the quintic NLS equation from different initial conditions through the symmetrical split-step Fourier method. We find many localized high-peak structures whose profiles are very similar to the analytical solutions, and we analyze the formation of rouge waves (RWs) in different cases. These results may be helpful to understand the excitation of nonlinear waves in some nonlinear fields, such as optical fibers, oceanography and so on.
Combination Therapy with miR-34a and Doxorubicin Synergistically Induced Apoptosis in T-Cell Acute Lymphoblastic Leukemia Cell Line
Authors: Najjary Shiva , Mohammadzadeh Reza , Mansoori Behzad , Vahidian Fatemeh , Mohammadi Ali , Doustvandi Mohammad Amin , Khaze Vahid , Hajiasgharzadeh Khalil , Baradaran Behzad 
Published: August 2021

Abstract
Reduced expression of tumor suppressor miRNAs leads to cancer cell development, so restoring the expression of these miRNAs can be an appropriate treatment option for cancer. Due to the heterogeneity of cancer cells, single-drug therapy often results in drug resistance. Therefore, the combination of chemotherapy with miRNA can be a powerful strategy for cancer treatment. In the current investigation, we researched the synergic effect of miR-34a in combination with doxorubicin (DOX) on cell death of acute T-cell lymphoblastic leukemia (T-ALL) Jurkat cell line, as well as the expression of some genes including Caspase-3, Bcl-2, and p53 which are involved in apoptosis. Our outcomes showed that the combination of miR-34a and doxorubicin remarkably reduced the expression of the Bcl-2 gene, the target gene of miR-34a. According to the results of the MTT assay in cells treated with miR-34a and doxorubicin, the survival rate was significantly decreased compared to the untreated cells. Results of the flow cytometry assay and DAPI staining demonstrated an increased apoptosis rate of Jurkat cells in combination therapy. Moreover, cell cycle arrest was observed at the G2/M phase in cells that were treated with miR-34a/doxorubicin. Most importantly, we showed that the transfection of the Jurkat cells with miR-34a increased the sensitivity of these cells to doxorubicin. Furthermore, the combination of miR-34a and doxorubicin drug effectively increased apoptosis of treated cells. Therefore, this method can be used as an impressive treatment for T-ALL.
The Effect of Intravenous Tranexamic Acid on Hemoglobin and Hematocrit Levels After Cesarean Delivery: a Randomized Controlled Clinical Trial
Authors: Jafarbegloo Esmat , Faridnyia Faride , nejad Atefeh sadat mohammad hoseini 
Published: August 2021

Abstract
Background: During a cesarean section, the mother loses a lot of blood. This bleeding can cause a drop in hemoglobin and hematocrit. Tranexamic acid, an anti-fibrinolytic agent, is a novel approach in an attempt to prevent this dreadful complication. This study aims to explore the effect of intravenous tranexamic acid on hemoglobin and hematocrit level after cesarean section(CS) in women who were low risk in postpartum hemorrhage.Methods: This prospective randomised placebo-controlled clinical trial was carried out on 50 pregnant women referred to Izadi hospital, Qom, Iran, 2017. women were divided into two groups of 25 cases using block randomization. The study group, 25 women, received tranexamic acid 10 minutes before CS whereas the control group, 25 women received distilled water. Hemoglobin and hematocrit levels were measured before and 12-24 hours after delivery. Results: There was no significant difference in pre-operative and 12-24 h post-operative hemoglobin and hematocrit levels between the two groups(p>0.05). Conclusions: Pre-operative prescription of 1gr tranexamic acid was not associated with improvement of post-operative hemoglobin and hematocrit.Trial registration: IRCT20091010002558N7.
Salicylic Acid Induced Physiological Responses of Microchaete Sp. NCCU-342 Under PQ Stress
Authors: Naaz Haleema , Afzal Bushra , Sami Neha , Yasin Durdana , Khan Nida Jamil , Fatma Tasneem 
Published: August 2021

Abstract
Weeds are the worst category of agricultural pests as they compete with crops for water, nutrients, and light, grow faster than crops and eventually reduces the crop productivity thereby increasing the production cost. Herbicide has been used as a management tool to control weeds, by modifying their physiological activities like reducing photosynthesis, increasing protease activity and free radicals etc. The application of non-selected herbicides kills not only the weeds but also non-target organisms including the main crop. Herbicides like paraquat have been used in rice fields but its toxic effects on other organisms is at par. Salicylic acid, a plant growth regulator, is known to regulate oxidative stress in plants subjected to unfavourable environmental conditions. Given this, the present study was designed to study the effect of salicylic acid in Microchaete sp. NCCU-342 exposed to paraquat. The results obtained demonstrated that the paraquat toxicity elevated MDA and H2O2 levels, indicating free radical formation. However, supplementation of salicylic acid in the culture medium reduced the paraquat toxicity. The content of MDA and H2O2 in presence of salicylic acid was similar to the control. It enhances phenolic compound (29.07%) and phytohormones content (IAA-2.96%, SA-96.59%) and regulate the redox state of the cells. A significant change (recorded in percentage) was observed in the antioxidant enzyme activities including SOD (121.62 %), CAT (30.38 %), APX (74.38 %), GPX (127 %) and GR (141%) in presence of paraquat and after supplementation of salicylic acid. Antioxidant assay confirmed the change in antioxidants in form of phenolic compounds. Salicylic acid supplementation also enhanced the antibacterial activity of cyanobacteria, highlighting that it induces resistance against biotic stress as well as the abiotic stress. This work provides evidence for the ability of salicylic acid to alleviate the paraquat-induced toxicity, maintain redox state and resist the cell against both biotic and abiotic stress.
A New Hybrid Method for Establishing Landslide Displacement Point Forecasting, Interval Forecasting and Probabilistic Forecasting
Authors: Wang Hong , Long Guangyu , Liao Jianxing , Xu Yan , Lv Yan 
Published: August 2021

Abstract
In addition to the inherent evolution trend, landslide displacement contains strong fluctuation and randomness, the omni-directional landslide displacement prediction is more scientific than single point prediction or interval prediction. In this work, a newly hybrid approach composed of double exponential smoothing (DES), variational mode decomposition (VMD), long short-term memory network (LSTM) and gaussian process regression (GPR), was proposed for point, interval and probabilistic prediction of landslide displacement. The proposed model includes two parts: (i) predicting the inherent evolution trend of landslide displacement by DES-VMD-LSTM; (ii) evaluating the uncertainty in the first prediction based on the GPR model. In the first part, DES is used to predict the trend displacement, VMD is used to extract the periodic and stochastic displacement from the residual displacement, and then LSTM is used to predict them. The triggering factors of periodic and stochastic displacement are screened by maximum information coefficient (MIC), and the screened factors are decomposed into low- and high-frequency components by VMD, to predict periodic and stochastic displacement respectively. The first cumulative displacement prediction results are achieved by adding the predicted trend, periodic and stochastic displacement. By setting the first predicted displacement as input and actual displacement as expected output, the point, interval and probability prediction of displacement are realized in GPR model. The plausibility of this method was validated firstly with the data from Bazimen (BZM) and Baishuihe (BSH) landslide in the Three Gorges Reservoir area. This model has potential capacity to realize deterministic prediction of displacement and exhibit uncertainty contained in displacement. A comparing study shows that this method has a high performance at point, interval and probability prediction of displacement.
Analysis of the effect of NEKs on the prognosis of patients with Non-small-cell lung carcinoma based on bioinformatics
Authors: YANG MENGXIA , GUO YIKUN , GUO XIAOFEI , MAO YUN , ZHU SHIJIE , WANG NINGJUN , LU DIANRONG 
Published: August 2021

Abstract
NEKs are proteins that are involved in various cell processes and play important roles in the formation and development of cancer. However, few studies have examined the role of NEKs in the development of non-small-cell lung carcinoma (NSCLC). To address this problem, the Oncomine, UALCAN, and the Human Protein Atlas databases were used to analyze differential NEK expression and its clinicopathological parameters, while the Kaplan-Meier, cBioPortal, GEPIA, and DAVID databases were used to analyze survival, gene mutations, similar genes, and biological enrichments. The rate of NEK family gene mutation was high (>50%) in patients with NSCLC, in which NEK2/4/6/8/ was overexpressed and significantly correlated with tumor stage and nodal metastasis status. In addition, the high expression of NEK2/3mRNA was significantly associated with poor prognosis in patients with NSCLC, while high expression of NEK1/4/6/7/8/9/10/11mRNA was associated with good prognosis. In summary, these results suggest that NEK2/4/6/8 may be a potential prognostic biomarker for the survival of patients with NSCLC.
Molecular docking study of copaíba oil interacting with the spike protein of Sars-CoV-2
Authors: Santos Willian Oliveira , Venâncio José Robson da Costa , Ferreira Fernanda Carla Lima , de Oliveira Glaura Caroena Azevedo , Rodrigues Aldimar Machado , Frazão Nilton Ferreira , Novais Erico Raimundo Pereira , Souza Divanizia do Nascimento , Novais Andrea de Lima Ferreira 
Published: August 2021

Abstract
COVID-19 triggered by Sars-CoV-2 has caused hundreds of thousands of deaths worldwide. Organic and inorganic compounds have been tested as potential inhibitors of this lethal virus. For these tests, several techniques are use to design molecules of biological interest for drug composition, in which molecular coupling plays an important role. In the present work, the compounds acids kaurenoic, copalic, and beta-caryophyllene that form the copaiba oil were studied as anti-inflammatories and opens the possibility to inhibit Sars-CoV-2. Molecular docking showed alkyl, pi-alkyl, conventional H-bond, unfavorable bump, and Van der Waals interactions. The calculated electrostatic potential maps showed the nucleophilic and electrophilic regions. The negative binding energies obtained for the three acids suggest the stability of the complexes. The minimum energy states for β-caryophyllene are lower than the other compounds analyzed, and it can be predicted that this is the most stable.
Definitive Results of a Phase III Adjuvant Trial Comparing Six Cycles of FEC-100 to Four Cycles of AC in Women with Operable Node-negative Breast Cancer: The NSABP B-36 Trial (NRG Oncology)
Authors: Geyer Charles E , Bandos Hanna , Rastogi Priya , Jacobs Samuel A , Robidoux Andre , Fehrenbacher Louis , Ward Patrick J , Polikoff Jonathan , Brufsky Adam M , Provencher Louise , Paterson Alexander H.G. , Hamm John T , Carolla Robert L , Baez-Diaz Luis , Julian Thomas B , Swain Sandra , Mamounas Terry , Wolmark Norman 
Published: August 2021

Abstract
PURPOSE: Results from adjuvant trials evaluating 6 cycles of epirubicin-based chemotherapy regimens suggested these programs may be more effective than 4 cycles of doxorubicin-based chemotherapy. METHODS: NSABP B-36 was a phase III clinical trial originally designed as a 2x2 factorial study comparing 6 cycles of FEC-100 (5-FU, epirubicin, cyclophosphamide) to 4 cycles of conventional AC (Adriamycin/cyclophosphamide) with celecoxib or placebo. Shortly after activation, concerns regarding increased cardiovascular risks among selective COX-2 inhibitors resulted in a decision to remove the celecoxib/placebo from the trial. Women with histologically node-negative invasive breast cancer who had undergone primary surgery with a lumpectomy or total mastectomy were eligible. Primary endpoint was disease-free survival (DFS).RESULTS: Between May 2004-July 2008, 2,722 patients were enrolled. Administration of FEC-100 did not result in improvement in DFS compared to AC (HR=1.09; 95% CI 0.92-1.29, p-value=0.31). The effect of FEC-100 compared to AC on DFS was significantly different for receptor-positive (HR=1.32, 95% CI=1.05-1.66) compared to receptor-negative patients (HR=0.86, 95% CI=0.66-1.11) (treatment-by-receptor status interaction p-value=0.02). There was no statistically significant difference in the effect of treatment on overall survival (OS) with FEC-100 compared to AC (HR=1.06; 95% CI 0.84-1.35, p-value=0.61). Overall, Grade 3 and 4 adverse events were more frequent in the FEC-100 group.CONCLUSIONS: The results of B-36 do not support use of six-cycle anthracycline-based regimens in node-negative breast cancer. Prolongation of anthracycline-based therapy with FEC-100 does not improve DFS or OS, relative to AC for 4 cycles, and was associated with expected increases in toxicity. A statistically significant interaction between treatment and hormone receptor status favoring AC in hormone-receptor-positive breast cancers is consistent with the hypothesis that optimal duration of chemotherapy may be four cycles in these patients. Late cardiac events and deaths prior to recurrence or second cancer were infrequent on both arms, but slightly higher with FEC-100.ClinicalTrials.gov: NCT00087178
Associations of the COVID-19 Pandemic With Social Wellbeing Indicators in Mexico
Authors: Vilar-Compte Mireya , Hernandez-F Mauricio , Gaitán-Rossi Pablo , Pérez Víctor , Teruel Graciela 
Published: August 2021

Abstract
Background: Public health measures for COVID-19 containment have implied economic and social life disruptions, which have been particularly deleterious in low- and middle-income countries (LMIC) due to high rates of informal employment, overcrowding, and barriers to accessing health services, amongst others social determinants. Mexico, a LMIC, is a country with a high COVID-19 mortality in which there has been a very limited governmental response to help mitigate such COVID-related disruptions. This study analyzes the association of the first wave of the COVID-19 crisis in Mexico with four wellbeing indicators: income, employment, anxiety, and food security. Methods: It uses pooled cross-sectional data (n=5,453) of five monthly nationally representative surveys collected between April and August 2020. Probit models are estimated to assess the association of the pandemic with job loss and anxiety; a multinomial logistic regression is estimated for food security, and an ordinary least squares regression assesses the association between the pandemic and changes in household’s income. Results: Females were significantly associated with worse outcomes for the 4 wellbeing measures with an average reduction of 2.3% in household income compared to pre-COVID-19 levels, an increased probability (6.4 pp) if being in a household that had lost jobs, decreased probability of food security (6.9 pp), and an increased risk of anxiety symptoms (8.5 pp). In addition, those with lower SES and household with children also reported worse outcomes for employment, income and food security. The month variable was also statistically significant in these models suggesting that as more months of the pandemic elapsed the effects persisted. Conclusion: The currents study documents hos the COVID-19 pandemic is associated with different wellbeing indicators in a LMIC. It suggests the urgent need to take actions to support vulnerable groups, particularly women, households with children and those in the lowest SES. If policy actions are not taken, the pandemic will increase social and gender disparities, and will jeopardize childhood development
Quality and Efficiency of Health Care Systems During the COVID-19 Pandemic: Assessment of G20 Unified Procurement Systems for Medical Equipment
Authors: Aljafari Abdulmalek 
Published: August 2021

Abstract
Background

Country level comparative studies on the performance and experiences of medical device procurement systems, in terms of both quality and efficiency, particularly during COVID-19 are lacking.
Objective

To evaluate the impact on healthcare cost and efficiency of four national models of medical device procurement. Further, to propose procurement system "best practices" using the response to COVID-19 as a reference.
Methods

A review of qualitative data drawn from public and private sources was conducted, as well as various studies related to national procurement systems in four G20 countries, to (1) identify differences, strengths and weaknesses; (2) evaluate how each system responded to the COVID-19 crisis; and, (3) identify best practices for policy-makers.
Results

While some governments have centralized the procurement of medical devices, developing a national scheme for tendering and purchase, other countries have deployed a decentralized approach where regions or even individual hospitals are responsible for all or some aspects of procurement. This dichotomy has led to a variety of efficiency and quality of service outcomes, with models implementing national uniformity achieving greater cost-savings. Furthermore centralized systems of procurement performed better during times of health crisis. It remains unclear whether these short-term savings lead to long-term efficiencies achieved through improved patient outcomes as data is lacking.
Conclusion

The available data indicates that countries that have adopted a centralized approach to the procurement of medical devices tend to have an advantage during times of crisis, as well as in the normal provision of healthcare services.
Response of Soil Biological Properties and Bacterial Diversity to Different Levels of Nitrogen Application in Sugarcane Fields
Authors: Yang Shangdong , Xiao Jian , Liang Tian , He Weizhong , Tan Hongwei 
Published: August 2021

Abstract
Field experiments were performed in early March 2019 at the farm of the Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences. Four concentrations of nitrogen application were employed as follows: that is, urea applications 964, 482, 96, 0 kg ha− 1, respectively. And 300 kg ha− 1 calcium, magnesium, and phosphorus were likewise applied in 4 different treatments. The results showed that the soil microbial biomass carbon and phosphorus were altered significantly by non- and low-nitrogen input. Moreover, the indexes of soil bacterial richness and diversity in the sugarcane field could be significantly improved, even by low nitrogen input. At the genus level, norank_f__SC-I-84, Mycobacterium, norank_f__Micropepsaceae, norank_f__norank_o__Saccharimonadales, norank_f__norank_o__Subgroup_2 and norank_f__Acetobacteraceae were the unique dominant bacteria in the soil with the high nitrogen input treatment. norank_f__JG30-KF-CM45 and Jatrophihabitans were the unique dominant genera in the moderate nitrogen input treatment. norank_f__norank_o__norank_c__Subgroup_6, HSB_OF53-F07, Streptomyces, norank_f__67 − 14, norank_f__norank_o__SBR1031 and norank_f__norank_o__norank_c__KD4-96 were the unique dominant genera in the low nitrogen input treatment. In contrast, FCPS473, Actinospica, 1921-2, Sinomonas, and norank_f__Ktedonobacteraceae were the unique dominant genera in CK (no nitrogen application treatment). It suggested that low nitrogen input was the most significant effect on the soil microbial biomass carbon and phosphorus in the sugarcane field. Moreover, low nitrogen input also can improve the diversity and richness of sugarcane soil bacteria. The dominant bacterial genera of low nitrogen input and the other treatments were different for the compositions of dominant bacteria, and the largest abundance difference of dominant bacterial genera was norank_f__norank_o__norank_c__Subgroup_6. However, whether low nitrogen stress can improve the yield and quality of sugarcane warrants further research.
Metal Doping Silicates as Inorganic Ion Exchange Materials for Environmental Remediation
Authors: Abou-Mesalam Mamdouh Mohamed , Abass Mohamed Ragab , Zakaria Essam Saleh , Hassan Ali Mostafa 
Published: August 2021

Abstract
Titano-silicate (TiSi) and in-situ dopped composites were obtained by precipitation technique. The composition of these materials was established by IR, XRD, TGA&DTA, and XRF. The capacity for Co(II), & Cd(II) ions revealed that Co-TiSi & Cd-TiSi is a higher capacity than those obtained for TiSi by 1.81, & 1.41 values, respectively. To explore the separation potentiality of Co-TiSi for studied cations distribution coefficients in HNO3 were estimated. Langmuir isotherm model is the most representative for discussing the sorption process with a maximum sorption capacity of 16.02, and 10.96 mg/g for Co(II), & Cd(II) ions, respectively. Co-TiSi is suitable for the column technique for the recovery of studied cations. The investigation proved that Co-TiSi composite is suitable for the uptake of the studied ions from liquid solutions and could be considered as potential material for the refining of effluent polluted with these ions.