bluuebunny/crossref_metadata_2025_split huggingface dataset:
How healthcare providers’ IT identity is formed and how it affects the use of telemonitoring: a qualitative interview study in COPD care
Authors: Renting Nienke , Brands Martijn R , Velthausz Emmie A B , Gouw Samantha C 
Published: February 2025

BackgroundTelemonitoring is a promising approach to facilitate patients’ self-management and improve health outcomes, especially among people with chronic health conditions. Yet, many healthcare organisations struggle to implement telemonitoring successfully. IT identity, an individual’s self-identification with an information technology (IT) tool, has been suggested to strongly predict and shape the use of technology. IT identity is related to three emotional responses: emotional energy, dependence and relatedness.ObjectiveTo explore how healthcare professionals’ IT identity is shaped, and how it affects their attitude towards and intended use of telemonitoring.DesignQualitative, semistructured interview study.SettingPrimary care and hospitals (general and academic) in the Netherlands.ParticipantsSixteen nurses, pulmonologists, general practitioners and researchers working in chronic obstructive pulmonary disease (COPD) care.ResultsParticipants expressed varying emotional responses regarding the use of telemonitoring. We associated participants’ responses with the three dimensions of IT identity. Regarding emotional energy, some expressed pride in innovating, while others lacked faith in using telemonitoring. Regarding dependence, different perceived intentions and needs for using telemonitoring were identified: to coach patients, prevent deterioration of health, achieve logistical advantages for patients and preserve the accessibility of healthcare. Regarding relatedness, some participants expressed a strong external but weak internal motivation to use telemonitoring.Based on emotional responses, we identified five manifestations of IT identity that illustrate how different healthcare professionals use telemonitoring in COPD care: the Scientist, Innovator, Protector, Empowerer and Conversationalist. These manifestations differ in their readiness to innovate and in their beliefs what it means to be a good healthcare provider: to protect or to coach.ConclusionHealthcare professionals’ emotional energy, dependence and relatedness regarding telemonitoring in COPD care shaped their IT identity and how they used telemonitoring. Implementation strategies tailored towards the five manifestations of IT identity could help the sustainable implementation of telemonitoring in clinical practice.
Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study
Authors: Das Priya Mehta-Gupta , Madewell Zachary J , Blau Dianna M , Whitney Cynthia G , Ramakrishnan Usha , Stein Aryeh D , Young Melissa F , Suchdev Parminder S 
Published: February 2025

ObjectivesTo evaluate how postmortem anthropometric malnutrition (PAM) measures align with expert panel attribution of malnutrition as a causal or significant condition in under-5 mortality (U5M).DesignCohort study using data from the Child Health and Mortality Prevention Surveillance network, incorporating clinical records, postmortem anthropometrics, minimally invasive tissue sampling, clinical abstraction and verbal autopsy to determine multiple causes of death.Setting/participants1405 deaths of children aged 1–59 months from six African countries between 2016 and 2023.Primary and secondary outcome measuresPAM was determined using z-scores from the WHO Child Growth Standards: underweight (weight-for-age<(−2)), wasting (arm circumference-for-age or weight-for-length<(−2)) and stunting (length-for-age <(−2)). Performance metrics (sensitivity (SE), specificity (SP) and positive predictive values (PPV)) were calculated to determine the alignment between PAM and expert panel attribution of malnutrition as a causal or significant condition to death.ResultsNearly 75% of cases demonstrated moderate-to-severe malnutrition by PAM, while expert panels attributed malnutrition in 41% of cases. Performance metrics varied across anthropometric indices: underweight exhibited the highest SE (89.7%), while wasting based on arm circumference had the highest SP (81.9%) and PPV (76.8%). Discrepancies between PAM classification and expert panel attribution differed significantly by site, age, location of death and preventability of death (p<0.05). Adjusted multivariate regression showed that expert panel attribution was more likely with increasing severity of PAM.ConclusionsThe proportion of U5M attributable to malnutrition ranged between 41% (expert panel attribution) and 74% (PAM). Variability in classification underscores the need for monitoring and quality improvement measures to address discrepancies. Improved alignment between PAM and panel assessments is essential for accurately identifying malnutrition-related deaths and designing effective interventions to reduce U5M.
Patient and family engagement interventions for enhancing patient safety in the perioperative journey: a scoping review
Authors: Seyfulayeva Ayshe , Fonte Bianca Ferreira , Alho Ana Margarida , Shaikh Anum , Nunes Ana Beatriz , Casaca Pedro Gonçalves Carvalho , Leite Andreia , Taha Ayda , Dhingra-Kumar Neelam , Sousa Paulo 
Published: February 2025

BackgroundSurgical procedures present intricate challenges within healthcare delivery, often associated with higher risks of adverse events compared with non-surgical contexts. Patient and family engagement (PFE) throughout the perioperative journey is a possibility to enhance care quality, safety and patient-centredness. However, literature addressing PFE across the entirety of the perioperative journey remains sparse.ObjectiveThe current scoping review aims to comprehensively map the existing interventions with PFE approach focused on improving patient safety across various types of surgical procedures throughout the perioperative journey. In addition, the review aims to understand the level and type of PFE approach adopted in this context.Eligibility criteriaArticles published in indexed peer-reviewed journals from 2003 to 2023, written in English, Portuguese or Spanish, that report on interventions with PFE approach targeting adult surgical patients, their families, caregivers, patient advocates and patient champions. The review includes articles reporting on both inpatient and ambulatory surgical patients.MethodsFollowing Joanna Briggs Institute guidelines and the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews framework, this review systematically searched PubMed, Web of Science, SCOPUS, CINAHL, and PsycINFO for relevant articles. Eligible interventions were categorised using PFE framework regarding the level of engagement and mapped according to the WHO Global Patient Safety Action Plan 2021–2030.ResultsOut of 765 records initially identified, 32 met the eligibility criteria for data extraction and analysis, of which 40% originated from the USA, followed by the UK (18%) and Canada (12%). 47% of the interventions targeted ‘multiple/all types’ of procedures, 19% focused on cardiothoracic surgeries and 9% on gynaecological procedures or organ transplant. The majority of the interventions (88%) focused on PFE at the direct care level, predominantly adopting a consultation-based approach. Furthermore, 81% of eligible interventions emphasised patient information and education, 16% addressed codevelopment of policy and 3% of interventions focused on patient advocacy.ConclusionThe findings show a predominant focus on PFE interventions targeting patient safety at the direct care level, particularly in the provision of patient information and education. However, interventions at organisational and policy-making levels are notably scarce. Further investment is required to promote interventions engaging patients and families at broader organisational and policy-making levels.
Clinical use and impact of mechanical circulatory support for myocardial infarction-related cardiogenic shock in the Netherlands: a registry-based propensity-matched analysis
Authors: Bogerd Margriet , Griffioen Alexander M , Bunge Jeroen J H , Peters Elma J , Ten Berg Sanne , Timmermans Marijke J C , Kraaijeveld Adriaan O , Lipsic Erik , Otterspoor Luuk C , Bleeker Gabe , Montero-Cabezas José M , Sjauw Krischan D , Meuwissen Martijn , Dubois Eric A , van Geuns Robert-Jan M , Henriques José P S 
Published: February 2025

BackgroundDespite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes.MethodsThis real-world, multicentre registry included CS patients undergoing percutaneous coronary intervention between 2017 and 2021 in 14 Dutch hospitals. The impact on clinical outcomes was analysed after 1:1 average propensity-score (aPS) matching.ResultsThis AMI-CS registry included 2217 patients with a mean age of 66.4 (±12.3) years and predominantly male (72.8%, n=1613). MCS was deployed in 516 patients (23.3%), of which the intra-aortic balloon pump was used most frequently (n=253, 49.0%). Impella was used in 94 patients (18.2%), extracorporeal membrane oxygenation in 68 patients (13.2%) and 95 patients (18.4%) received multiple devices. Patients receiving MCS were younger (64.2 vs 67.0, p<0.01), presented with lower mean arterial pressures (74.7 vs 78.4 mm Hg, p<0.01), higher heart rates (88.3 vs 81.7 beats per minute, p<0.01) and higher initial lactate levels (6.4 vs 5.4 mmol/L, p<0.01). The percentage of resuscitated patients was comparable among MCS and non-MCS patients (38.6% vs 42.2%, p=0.17). The 30-day mortality rate was higher in MCS patients (55.0% vs 34.7%, p<0.01). After aPS-matching (n=970), 30-day mortality remained higher for MCS patients (53.8% vs 44.7%, p<0.01), with an associated OR of 1.44 (95% CI 1.12 to 1.85, p<0.01).ConclusionsDespite limited evidence, MCS was used in a fourth of all AMI-CS patients. MCS usage was associated with an increased 30-day mortality in this real-world setting, even after propensity-matching.
Peripandemic outcomes of infants treated for sentinel congenital heart diseases in England and Wales
Authors: Huang Qi , Lawlor Deborah A , Nolan John , Espuny-Pujol Ferran , Caputo Massimo , Pagel Christina , Crowe Sonya , Franklin Rodney CG , Brown Kate L 
Published: February 2025

BackgroundInfants with congenital heart disease (CHD) are clinically vulnerable to cardiac deteriorations and intercurrent infections. We aimed to quantify the impact of health system disruptions during the COVID-19 pandemic, on their clinical outcomes and whether these differed by socioeconomic and ethnic subgroups.MethodsIn this population-based cohort study, we used linked electronic healthcare datasets from England and Wales to identify infants with nine sentinel CHDs born and undergoing intervention in 2018–2022. The outcomes of cardiac intervention timing, infant mortality and hospital care utilisation, were described by birth eras, and risk factors were explored using multivariable regression.ResultsOf 4900 included infants, 1545 (31.5%) were born prepandemic (reference), 1175 (24.0%) in the transition period, 1375 (28.0%) during restrictions and 810 (16.5%) postrestrictions. The casemix was hypoplastic left heart syndrome (195; 3.9%), functionally univentricular heart (180; 3.7%), transposition (610; 13.5%), pulmonary atresia (290; 5.9%), atrioventricular septal defect (590; 12.1%), tetralogy of Fallot (820; 16.7%), aortic stenosis (225; 4.6%), coarctation (740; 15.1%) and ventricular septal defect (1200; 24.5%).Compared with prepandemic, there was no evidence for delay in treatment procedures in transition, restrictions or postrestrictions eras. Infant mortality increased for those born in the transition period, adjusted OR 1.60 (95% CI 1.06, 2.42) p=0.01, but not in restrictions or postrestrictions. The days spent at home were similar with birth in transition and restrictions, but fewer for postrestrictions, adjusted days difference −2 (95% CI −4, 0), p=0.05.Outcomes did not vary by pandemic birth era according to social characteristics. There was higher infant mortality in the deprived versus non-deprived binary category (adjusted OR 1.56 (95% CI 1.11, 2.18), p=0.004) and there were fewer days spent at home for the most versus least deprived neighbourhood quintile (adjusted difference −4 (95% CI −6, –2), p<0.001).ConclusionsSpecialist care for infants with CHD during the pandemic, in terms of pathway procedure timing and healthcare contacts, was not compromised. Increased healthcare utilisation postpandemic and heath inequality based on socioeconomic status require further evaluation.
SIRT2 regulates the SMARCB1 loss-driven differentiation block in ATRT
Authors: Alimova Irina , Wang Dong , DeSisto John , Danis Etienne , Lakshmanachetty Senthilnath , Prince Eric , Murdock Gillian , Pierce Angela , Donson Andrew , Balakrishnan Ilango , Serkova Natalie , Lin Hening , Foreman Nicholas K. , Dahl Nathan , Venkataraman Sujatha , Vibhakar Rajeev 
Published: February 2025

Abstract
Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive pediatric brain tumor driven by the loss of SMARCB1, which results in epigenetic dysregulation of the genome. SMARCB1 loss affects lineage commitment and differentiation by controlling gene expression. We hypothesized that additional epigenetic factors co-operate with SMARCB1 loss to control cell self-renewal and drive ATRT. We performed an unbiased epigenome targeted screen to identify genes that co-operate with SMARCB1 and identified SIRT2 as a key regulator. Using in vitro pluripotency assays combined with in vivo single cell RNA transcriptomics, we examined the impact of SIRT2 on differentiation of ATRT cells. We employed a series of orthotopic murine models treated with SIRT2 inhibitors to examine the impact on survival and clinical applicability. We found that ATRT cells are highly dependent on SIRT2 for survival. Genetic or chemical inhibition led to decrease cell self-renewal and induction of differentiation in tumor spheres and in vivo models. We found that SIRT2 inhibition can restore gene expression programs lost due to SMARCB1 loss and reverse the differentiation block in ATRT in vivo. Finally, we showed the in vivo efficacy of a clinically relevant inhibitor demonstrating SIRT2 inhibition as a potential therapeutic strategy. We concluded that SIRT2 is a critical dependency in SMARCB1 deficient ATRT cells and acts by controlling the pluripotency-differentiation switch. Thus, SIRT2 inhibition is a promising therapeutic approach that warrants further investigation and clinical development. Implications: SIRT2 inhibition is a molecular vulnerability in SMARCB1-deleted tumors.
Online teaching style: insights of faculty and students’ perspectives and student engagement
Authors: Padmaja Goteti Venkata , Malay Jhancy , Sultana Juveria , Rangraze Imran Rashid , Harshita Chilakalapalli Ramya 
Published: February 2025

<div align="center">Medical education had a paradigm shift to online learning during COVID 19 pandemic. The studies conducted identify the benefits and limitations of online learning but not much studies on the faculty and students’ perceptions of faculty online teaching style and the degree of online student engagement. The study was done at Kakatiya Medical College, India. At the end of one year of online teaching to the novice foundation year students during lockdown period, the faculty and students’ perceptions on faculty’s online teaching styles and degree of student engagement were recorded using teaching style inventory (TSI) and online student engagement questionnaire. The study found that 60% of the faculty and 42% of the students perceived that the faculty adopted collaborative teaching style, thus the perception difference was significant (p=0.05). The perception of other teaching styles such as suggestive, assertive, and facilitative among faculty and students were different but statistically not significant. Students positively engaged when faculty practiced facilitative and collaborative teaching styles. To conclude, facilitative, and collaborative, teaching methods help medical students’ motivation for online engagement. Medical students were better engaged with online instruction when instructors gave prompt responses to questions, insightful criticism of work, and individualized coaching.</div><p align="center"> </p>
The relationship between physical activity level, dietary patterns, and metabolic syndrome: An empirical study in Saudi Arabia
Authors: Alhajrim Ahlam Saleh , Alanzi Turki , Alzahrani Wala , Alshehab Hassan Abdullah , Alanazi Elham , Alhajri Esmat , Aljamaan Nahla , Aldandan Fadhel Abbas Ali , Almumttin Zahra , Alnwaisser Mariam , Abdullah Almajed Zahrah , Alzahrani Amaal , Alanzi Nouf 
Published: February 2025

Background Metabolic syndrome, a cluster of conditions increasing the risk of heart disease, stroke, and diabetes, is a growing concern globally. In Saudi Arabia, lifestyle factors such as physical activity and dietary patterns play a significant role in the prevalence of metabolic syndrome. Study Purpose This study aims to explore the relationship between physical activity levels, dietary patterns, and the prevalence of metabolic syndrome among adults in Saudi Arabia. Methods A cross-sectional study was conducted using purposive and convenience sampling techniques. A total of 468 participants completed questionnaires assessing their physical activity levels and dietary patterns. Metabolic syndrome was determined based on clinical measurements of waist circumference, blood pressure, fasting glucose, and lipid levels. Results The analysis revealed a significant association between lower physical activity levels and poor dietary patterns with higher prevalence rates of metabolic syndrome. The analysis revealed that participants with low physical activity levels had a higher prevalence of metabolic syndrome ( p < 0.01). Similarly, those with unhealthy dietary patterns (high in saturated fats and sugars) showed a metabolic syndrome risk ( p < 0.01), compared to those with healthy dietary patterns. Conclusion The findings underscore the critical role of physical activity and dietary patterns in the development of metabolic syndrome in Saudi Arabia. Public health interventions targeting lifestyle modifications could be essential in mitigating metabolic syndrome and improving overall health.
Evaluation of potential markers of early infection in patients undergoing elective colorectal malignancy surgery
Authors: Calik Bulent , Calik Sebnem , Yildirim Mehmet , Kamer Erdinç , Tosun Selma , Kavak Selcuk 
Published: February 2025

Objectives We aimed to investigate the value of leukocyte biomarkers and disease scores for the early detection of infection in patients who have undergone elective colorectal surgery for malignancy. Methods We conducted a prospective study at a training and research hospital. Patients who developed infection were considered to be an Infection group, and the others were regarded as a Control group. For individuals in both groups, the Sequential Organ Failure Assessment Score (SOFA), quick SOFA, and National Early Warning Score (NEWS) were calculated and blood samples were collected for flow cytometry analysis. A model was developed using logistic regression analysis to identify parameters that were predictive of mortality. Results One hundred thirty-two patients were included in the study. Infections developed in 36 (27.3%) of the participants, of which 14 (38.9%) were intra-abdominal, 10 (27.8%) were pneumonia, 8 (22.2%) were superficial incisional infections, and 4 (11.1%) were urinary tract infections. The NEWS was the most effective parameter for the detection of early infection in patients undergoing surgery for colorectal malignancy. Conclusion The NEWS score can be easily used to predict infection soon after surgery for colorectal malignancy.
Spatial clusters and temporal trends of cutaneous malignant melanoma mortality in Spain
Authors: Cayuela Lucía , Pereyra-Rodriguez José-Juan , Hernández-Rodríguez Juan-Carlos , Cayuela Aurelio 
Published: February 2025

Objective To analyse time trends in mortality due to cutaneous malignant melanoma (CMM) in Spain between 1980 and 2020, and to identify possible spatial clusters of provinces with an excess risk of CMM mortality during the period 2011–2020. Methods Joinpoint regression models were used to assess temporal trends in data from the Spanish National Institute of Statistics. Crude rates, standardized mortality ratio (SMR), smoothed relative risk (RR), and posterior probabilities (PP) of RR >1 during the period 2011–2020 were calculated. The Global Moran I index was used to assess global spatial autocorrelation. Results Two time-periods were detected in women: a significant increase during 1980–1994 (annual percent change [APC], 6.5% per year) and rate stabilization during 1994–2020 (nonsignificant APC, −0.17%). A similar pattern was observed in men, with three periods comprising a significant increase during 1980–1985 (APC, 16.59%), a slowing of the increase during 1985–1998 (APC, 4.40%), and stabilization during 1998–2020 (nonsignificant APC, 0.37%). Spatial analysis showed greater spatial heterogeneity with an east-north pattern in men compared with the pattern in women, which tended to be concentrated in north-western areas. Conclusion Mortality rates associated with CMM in Spain have remained stable in recent years. There were provincial clusters that exhibited an excess risk of mortality from CMM, with different patterns according to sex.
Relationship between plasma polymyxin B concentrations and acute kidney injury in critically ill elderly patients: Findings from a prospective study
Authors: Zhao Changyun , Mao Wenchao , Ye Feifei , Cai Kailun , Gong Shijin , Ye Cong , Yu Yihua 
Published: February 2025

Objective The objective of this study was to determine the relationship between the plasma polymyxin B concentration and renal function in elderly patients. Methods This prospective, case-control, observational study included elderly patients who received polymyxin B therapy and were divided into an acute kidney injury (AKI) group and a non-AKI group based on their renal function. We monitored the pharmacokinetics and pharmacodynamics of polymyxin B, including the minimum plasma concentration (Cmin), mean blood drug concentration at steady state (Css,avg), and area under the concentration-time curve across 24 h at steady state (AUCss,24h) in both study groups. The plasma polymyxin concentration was determined using high-performance liquid chromatography-tandem mass spectrometry. Results The loading doses, Cmin, Css,avg, and AUCss,24h were significantly higher in the AKI group than in the non-AKI group ( p < 0.05). Receiver-operating characteristic curve analysis showed that the optimal cutoff values for predicting AKI were 2.94 mg/L for Cmin, 4.14 mg/L for Css,avg, and 99.35 mg·h/L for AUCss,24h, with corresponding sensitivities and specificities ranging from 78.57% to 82.14%. Conclusion Monitoring plasma polymyxin B concentrations is essential in elderly patients. Keeping the Cmin below 2.94 mg/L, the Css,avg below 4.14 mg/L, and the AUCss,24h below 99.35 mg h/L may help prevent AKI in this population.