bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial Differences in the Phenotype of Colorectal Cancer: A Prospective Comparison Between Nigeria and South Africa
Authors: Alatise Olusegun I. , Knapp Gregory C. , Bebington Brendan , Ayodeji Patrick , Dare Anna , Constable Jeremy , Olasehinde Olalekan , Kingham T. Peter 
Published: September 2021

AbstractIntroductionThere are significant differences in the phenotype of CRC by race in the U.S. A similar CRC phenotype‐race relationship also appears to exist in South Africa (SA). However, there is a paucity of comparative data on the presentation and survival of CRC in sub‐Saharan African by country of origin or race. This study compares clinicopathologic variables between CRC patients in Nigeria and SA.MethodsFrom a prospective CRC database, consecutive patients diagnosed between September, 2013 and October, 2018 from the African Research Group for Oncology in South West Nigeria were compared to consecutive patients diagnosed from January, 2016 to October, 2018 from the Colorectal Cancer in South Africa database. Patients with histologically confirmed adenocarcinoma were included. Patients were excluded if they had in‐situ disease or no histological diagnosis. Clinical outcomes were calculated from the date of presentation. National census categories were used to define self‐reported race in SA.ResultsThe mean age at presentation in Nigeria (n = 347) was 54.1 years (SD 15.5) compared to 56.8 (SD 13.7) in SA (n = 534). The median age among Black SA (BSA) patients was significantly lower than the median age among White SA (WSA) patients (55 vs. 63, p < 0.001). Right‐sided colon cancer was more common in Nigerian (27.4%) and BSA (21.2%) patients compared to WSA patients (15.2%, p < 0.001). Nigerian (39.1%) and BSA (16.7%) patients were also more likely to present with mucinous histology than WSA patients (4.9%, p < 0.001). There was a significant difference in the stage‐at‐presentation between the cohorts, with a large burden of stage IV disease in the Nigerian cohort (52.6%). Adjusting for stage‐at‐presentation, there was a significant difference in the median overall survival between country and racial cohorts.ConclusionThere are significant differences in the phenotype of CRC between Nigeria and SA. Nigerian and BSA patients, appear to share characteristics that are different than those of WSA patients. Larger series with tissue banking and next‐generation sequencing are needed to better delineate these observed differences.
Epstein–Barr virus and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation in patients with non–Hodgkin lymphoma: the prevalence and impacts on outcomes
Authors: Ding Yiyang , Ru Yuhua , Song Tiemei , Guo Lingchuan , Zhang Xiang , Zhu Jinjin , Li Caixia , Jin Zhengming , Huang Haiwen , Tu Yuqing , Xu Mimi , Xu Yang , Chen Jia , Wu Depei 
Published: September 2021

AbstractEpstein–Barr virus (EBV) and cytomegalovirus (CMV) reactivations are common complications after allogeneic hematopoietic cell transplantation (allo-HCT), but data focusing on non–Hodgkin lymphoma (NHL) are limited. We retrospectively analyzed the prevalence of EBV and CMV reactivation post-allo-HCT and the impacts on transplant outcomes in 160 NHL patients. The 1-year incidences of EBV and CMV reactivation were 22.58% and 25.55%, respectively. Independent impactors for EBV reactivation were more than 6 lines of chemotherapy (P = 0.030), use of rituximab (P = 0.004), and neutrophil recovery within 30 days post-HCT (P = 0.022). For T-cell lymphoblastic lymphoma patients, the International Prognostic Index (IPI) (P = 0.015) and chronic GVHD (P = 0.001) increased the risk of CMV reactivation. CMV reactivation was independently related to a lower risk of relapse (P = 0.027) but higher transplant-related mortality (TRM) (P = 0.038). Although viral reactivation had no significant impact on overall survival (OS) in the whole cohort, it led to an inferior 2-year OS (67.6% versus 92.5%, P = 0.005) and TRM (20.1% versus 4.7%, P = 0.020) in recipients surviving for more than 180 days. We concluded that EBV and CMV reactivation post-allotransplant still deserved concern particularly in NHL patients with high-risk factors, since it is generally related to a deteriorated prognosis. Large-scale studies are warranted to validate our findings.
Distinguishing level-1 phylogenetic networks on the basis of data generated by Markov processes
Authors: Gross Elizabeth , van Iersel Leo , Janssen Remie , Jones Mark , Long Colby , Murakami Yukihiro 
Published: September 2021

AbstractPhylogenetic networks can represent evolutionary events that cannot be described by phylogenetic trees. These networks are able to incorporate reticulate evolutionary events such as hybridization, introgression, and lateral gene transfer. Recently, network-based Markov models of DNA sequence evolution have been introduced along with model-based methods for reconstructing phylogenetic networks. For these methods to be consistent, the network parameter needs to be identifiable from data generated under the model. Here, we show that the semi-directed network parameter of a triangle-free, level-1 network model with any fixed number of reticulation vertices is generically identifiable under the Jukes–Cantor, Kimura 2-parameter, or Kimura 3-parameter constraints.
Annotated expression and activity data for murine recombinase alleles and transgenes: the CrePortal resource
Authors: Perry Michelle N. , Smith Constance M. , Onda Hiroaki , Ringwald Martin , Murray Stephen A. , Smith Cynthia L. 
Published: September 2021

AbstractRecombinase alleles and transgenes can be used to facilitate spatio-temporal specificity of gene disruption or transgene expression. However, the versatility of this in vivo recombination system relies on having detailed and accurate characterization of recombinase expression and activity to enable selection of the appropriate allele or transgene. The CrePortal (http://www.informatics.jax.org/home/recombinase) leverages the informatics infrastructure of Mouse Genome Informatics to integrate data from the scientific literature, direct data submissions from the scientific community at-large, and from major projects developing new recombinase lines and characterizing recombinase expression and specificity patterns. Searching the CrePortal by recombinase activity or specific recombinase gene driver provides users with a recombinase alleles and transgenes activity tissue summary and matrix comparison of gene expression and recombinase activity with links to generation details, a recombinase activity grid, and associated phenotype annotations. Future improvements will add cell type-based activity annotations. The CrePortal provides a comprehensive presentation of recombinase allele and transgene data to assist researchers in selection of the recombinase allele or transgene based on where and when recombination is desired.
Surgery of congenital breast asymmetry—which objective parameter influences the subjective satisfaction with long-term results
Authors: Noisser Vivien , Eigenberger Andreas , Weiherer Maximilian , Seitz Stephan , Prantl Lukas , Brébant Vanessa 
Published: September 2021

Abstract
Purpose
Congenital breast asymmetry is a serious gynecological malformation for affected patients. The condition hits young women in puberty and is associated with socio-esthetic handicap, depression, and psychosexual problems. Surgical treatment is usually early in the patient's lifetime, so a long-term sustainable solution is important. Although postoperative outcome has been evaluated in several studies before, this study is the first to analyze which objective parameters have the greatest influence on subjective satisfaction with long-term results.

Methods
Thirty-four patients diagnosed with congenital breast asymmetry that underwent either lipofilling or implant therapy between the years of 2008 to 2019 were examined. On average, our collective comprised patients seven years after surgery. Data were mainly gathered through manual measurements, patient-reported outcome measures (Breast Q™), and breast volumetry based on 3D scans (Vectra® H2, Canfield Scientific).

Results
Among all analyzed parameters, only areolar diameter correlated significantly negatively with the subjective outcome satisfaction of the patient. Regarding the subjective assessment of postoperative satisfaction with similarity of the breasts, again the mean areolar diameter, but also the difference in areolar diameter and breast volume between the right and left breasts correlated significantly negatively.

Conclusion
Areolar diameter was revealed as being a significant factor influencing subjective long-term satisfaction in breast asymmetry patients. Moreover, 3D volumetry proves to be an effective tool to substantiate subjective patient assessments. Our findings may lead to further improvements to surgical planning and will be expanded in further studies.
Cardiac surgery for patients with schizophrenia: clinical experience of six patients
Authors: Tanaka Mutsuo , Okamoto Minoru , Yamashita Kensho 
Published: September 2021

Abstract
Purpose
The incidence of schizophrenia in Japan is 0.7%, which is similar to the worldwide incidence. The mortality rate of patients with schizophrenia is reported to be higher than that of the general population, and cardiovascular disease is high among the causes of death. Hence, strategies for cardiovascular surgery for patients with schizophrenia are necessary.

Methods
We studied six patients with schizophrenia (five males, one female) who underwent cardiac surgery in our hospital between April 2008 and December 2019.

Result
The mean age was 63.6 years. The surgical procedures were coronary artery bypass grafting (CABG) (n = 4), CABG concomitant with valve procedures (n = 1), and resection of myxoma (n = 1). There were no major cardiovascular complications and no other fatal complications. The mean observation period was 1510.6 ± 1430.1 (140–4068) days, the mean post-operative hospital stay was 17.8 ± 3.5 (13–22) days, and there was no mortality within 30 days after surgery.
During the observation period, one patient died. The survival rate was 83.3% at 1, 3, and 5 years.

Conclusion
Cardiac surgery for patients with schizophrenia is possible with careful monitoring of indications and perioperative management.
Multiple ictal onset patterns underlie seizure generation in seizure-free patients with temporal lobe epilepsy surgery: an SEEG study
Authors: Xu Cuiping , Zhang Xiaohua , Yan Xiaoming , Ma Kai , Wang Xueyuan , Zhang Xi , Ni Duanyu , Qiao Liang , Yu Tao , Zhang Guojun , Wang Yuping , Li Yongjie 
Published: September 2021

Abstract
Purpose
Seizure originates from different pathological substrate; however, the same pathologies may have distinct mechanisms underlying seizure generation. We aimed to improve the understanding of such mechanisms in patients with temporal lobe epilepsy (TLE) by investigating the stereoelectroencephalography (SEEG) ictal onset patterns (IOPs).

Methods
We analyzed data from a cohort of 19 consecutive patients explored by SEEG and had 1–3-year seizure-freedom following temporal lobe resection.

Results
Six IOPs were identified. They were low voltage fast activity (LVFA) (36.5%), rhythmic spikes or spike-waves at low frequency and with high amplitude (34.1%), runs of spikes (10.6%), rhythmic sharp waves (8.2%), low frequency high amplitude repetitive spiking (LFRS) (7.1%), and delta activity (3.5%). All six patterns were found in patients with mesial temporal onset and only two patterns were found in patients with temporal neocortical onset. The most prevalent patterns for patients with mesial temporal onset were rhythmic spikes or spike-waves, followed by LVFA with a mean discharge rate 74 Hz. For patients with temporal neocortical onset, the most prevalent IOP pattern was LVFA with a mean discharge rate 35 Hz, followed by runs of spikes. Compared with Lateral TLE (LTLE), the duration between the onset of the IOPs to the onset of the symptom was longer for patients with MTLE (Mesial TLE) (MTLE:55.7 ± 50.6 s vs LTLE:19.5 ± 16.4 s).

Conclusion
Multiple IOPs underlie seizure generation in patients with TLE. However, the mesial and lateral temporal lobes share distinct IOPs.
Neuroglobin Provides a Convenient Scaffold to Investigate the Triplet-State Properties of Porphyrins by Time-Resolved EPR Spectroscopy and Magnetophotoselection
Authors: Ciuti Susanna , Barbon Antonio , Bortolus Marco , Agostini Alessandro , Bergantino Elisabetta , Martin Caterina , Di Valentin Marilena , Carbonera Donatella 
Published: September 2021

AbstractThe photo-excited triplet state of Zn-protoporphyrin IX located in the heme pocket of human neuroglobin has been investigated by time-resolved EPR coupled to magnetophotoselection. The triplet state in the protein matrix has been compared with the model complex in organic glass, considering both non-coordinating and coordinating solvent mixtures. The protein matrix plays an important role in stabilizing the coordination of the embedded chromophore, resulting in a more homogeneous environment relative to that of the chromophore in a glassy solvent, even in the presence of an axial nitrogenous ligand like pyridine. The EPR spectral parameters point out a slow Jahn–Teller interconversion between slightly different triplet states, both in organic solvent and in the protein matrix. The EPR-magnetophotoselection allows us to propose a reinterpretation of the assignment of the Q bands in the electronic absorption spectrum.
Comparing self-report and parental report of psychopathologies in adolescents with substance use disorders
Authors: Kuitunen-Paul Sören , Eichler Anna , Wiedmann Melina , Basedow Lukas A. , Roessner Veit , Golub Yulia 
Published: September 2021

AbstractBoth internalizing and externalizing psychopathologies interfere with the treatment of substance use disorders (SUD) in adolescents. Self-reports of psychopathologies are likely biased and may be validated with parental reports. We compared N = 70 standardized self-reports of adolescents entering outpatient SUD treatment (13.2–18.6 years old, 43% female) to parental reports on the same psychopathologies, and explored biases due to gender, age, SUD diagnoses and SUD severity. Bivariate bootstrapped Pearson correlation coefficients revealed several small to moderate correlations between both reporting sources (r = 0.29–0.49, all pcorrected ≤ 0.039). A repeated measures MANOVA revealed moderately stronger parental reports of adolescent psychopathologies compared to adolescent self-reports for most externalizing problems (dissocial and aggressive behaviors, p ≤ 0.016, η2part = 0.09–0.12) and social/attention problems (p ≤ 0.012, η2part = 0.10), but no differences for most internalizing problems (p ≥ 0.073, η2part = 0.02–0.05). Differences were not associated with other patient or parental characteristics including age, gender, number of co-occurring diagnoses or presence/absence of a certain SUD (all puncorrected ≥ 0.088). We concluded that treatment-seeking German adolescents with SUD present with a multitude of extensive psychopathologies. The relevant deviation between self- and parental reports indicate that the combination of both reports might help to counteract dissimulation and other reporting biases. The generalizability of results to inpatients, psychiatry patients in general, or adolescents without SUD, as well as the validity of self- and parental reports in comparison to clinical judgements remain unknown.
Energy mix, technological change, and the environment
Authors: Bongers Anelí 
Published: September 2021

AbstractThis paper studies the relationship between the energy mix and the environment using a theoretical framework in which two alternative energy sources are considered: fossil fuels (dirty energy) and renewable energy (clean energy). We find that a positive aggregate productivity shock increases energy consumption and emissions but reduces energy intensity and emissions per unit of output as renewable energy consumption increases, that is, carbon emissions are procyclical but emissions per unit of output are countercyclical. Second, an energy efficiency improvement provokes a “rebound effect” above 100% (the backfire effect), resulting in a rise of pollutant emissions by increasing energy use. Third, a technological improvement in emissions leads to a reduction in emissions per unit of fossil fuel, but also implies a slow-down in the adoption of renewable energy sources. Finally, we consider the case of a decentralized economy in which the government chooses an optimal specific tax on fossil fuel to maximize social welfare. We show that the “second-best” policy is highly effective in correcting the negative effects of the environmental externality and able to almost achive the centralized economy outcome.
Triaxial compression behavior of 3D printed and natural sands
Authors: Ahmed Sheikh Sharif , Martinez Alejandro 
Published: September 2021

AbstractDifferent particle properties, such as shape, size, surface roughness, and constituent material stiffness, affect the mechanical behavior of coarse-grained soils. Systematic investigation of the individual effects of these properties requires careful control over other properties, which is a pervasive challenge in investigations with natural soils. The rapid advance of 3D printing technology provides the ability to produce analog particles with independent control over particle size and shape. This study examines the triaxial compression behavior of specimens of 3D printed sand particles and compares it to that of natural sand specimens. Drained and undrained isotropically-consolidated triaxial compression tests were performed on specimens composed of angular and rounded 3D printed and natural sands. The test results indicate that the 3D printed sands exhibit stress-dilatancy behavior that follows well-established flow rules, the angular 3D printed sand mobilizes greater critical state friction angle than that of rounded 3D printed sand, and analogous drained and undrained stress paths can be followed by 3D printed and natural sands with similar initial void ratios if the cell pressure is scaled. The results suggest that some of the fundamental behaviors of soils can be captured with 3D printed soils, and that the interpretation of their mechanical response can be captured with the critical state soil mechanics framework. However, important differences in response arise from the 3D printing process and the smaller stiffness of the printed polymeric material.Graphic abstractArtificial sand analogs were 3D printed from X-ray CT scans of sub-rounded and sub-angular natural sands. Triaxial compression tests were performed to characterize the strength and dilatancy behavior as well as critical staste parameters of the 3D printed sands and to compare it to that exhibited by the natural sands.
Critical numerical analysis of quasi-two-dimensional silo-hopper discharging
Authors: Blanco-Rodríguez Rodolfo , Hidalgo Raúl Cruz , Pérez-Ángel Gabriel , Maza Diego 
Published: September 2021

AbstractWe present a critical comparative analysis between numerical and experimental results of quasi-two-dimensional silo and hopper flows. In our approach, the Discrete Element Method was employed to describe a single-layer mono-disperse sphere confined by two parallel walls with an orifice at the bottom. As a first step, we examined the discharge process, varying the size of the outlet and the hopper angle. Next, we set the simulation parameters fitting the experimental flow rate values obtained experimentally. Remarkably, the numerical model captured the slight non-monotonic dependence of the flow rate with the hopper angle, which was detected experimentally. Additionally, we analyzed the vertical velocity and solid fractions profiles at the outlet numerically and experimentally. Although numerical results also agreed with the experimental observations, a slight deviation appeared systematically between both approaches. Finally, we explored the impact of the system’s confinement on this process, examining the consequences of particle-particle and particle-wall friction on the system macroscopic response. We mainly found that the degree of confinement and particle-wall friction have a relevant impact on the outflow dynamics. Our analysis demonstrated that the naive 2D approximation of this 3D flow process fails to describe it accurately.
Perioperative red blood cell transfusion is associated with poor functional outcome and overall survival in patients with newly diagnosed glioblastoma
Authors: Schneider Matthias , Schäfer Niklas , Potthoff Anna-Laura , Weinhold Leonie , Eichhorn Lars , Weller Johannes , Scharnböck Elisa , Schaub Christina , Heimann Muriel , Güresir Erdem , Lehmann Felix , Vatter Hartmut , Herrlinger Ulrich , Schuss Patrick 
Published: September 2021

AbstractThe influence of perioperative red blood cell (RBC) transfusion on prognosis of glioblastoma patients continues to be inconclusive. The aim of the present study was to evaluate the association between perioperative blood transfusion (PBT) and overall survival (OS) in patients with newly diagnosed glioblastoma. Between 2013 and 2018, 240 patients with newly diagnosed glioblastoma underwent surgical resection of intracerebral mass lesion at the authors’ institution. PBT was defined as the transfusion of RBC within 5 days from the day of surgery. The impact of PBT on overall survival was assessed using Kaplan–Meier analysis and multivariate regression analysis. Seventeen out of 240 patients (7%) with newly diagnosed glioblastoma received PBT. The overall median number of blood units transfused was 2 (95% CI 1–6). Patients who received PBT achieved a poorer median OS compared to patients without PBT (7 versus 18 months; p < 0.0001). Multivariate analysis identified “age > 65 years” (p < 0.0001, OR 6.4, 95% CI 3.3–12.3), “STR” (p = 0.001, OR 3.2, 95% CI 1.6–6.1), “unmethylated MGMT status” (p < 0.001, OR 3.3, 95% CI 1.7–6.4), and “perioperative RBC transfusion” (p = 0.01, OR 6.0, 95% CI 1.5–23.4) as significantly and independently associated with 1-year mortality. Perioperative RBC transfusion compromises survival in patients with glioblastoma indicating the need to minimize the use of transfusions at the time of surgery. Obeying evidence-based transfusion guidelines provides an opportunity to reduce transfusion rates in this population with a potentially positive effect on survival.