bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Do Healthcare Professionals Make Decisions Concerning Low Value Care Practices? Study Protocol of a Factorial Survey Experiment on De-Implementation
Authors: Roczniewska Marta , Schwarz Ulrica von Thiele , Augustsson Hanna , Nilsen Per , Ingvarsson Sara , Hasson Henna 
Published: May 2021

Abstract
Background

A large number of practices used in health care lack evidence of effectiveness and may be unnecessary or even cause harm. As such, they should be de-implemented. While there are multiple actors involved in de-implementation of such low value care (LVC) practices, ultimately, the decision to abandon a practice is often made by each health care professional. A recent scoping review identified 6 types of factors affecting the utilization vs. abandonment of LVC practices. These factors concern: health care professionals, patients, outer context, inner context, processes, as well as the characteristics of LVC practice itself. However, it is unclear how professionals weigh these different factors in, and how these determinants influence their decisions about abandoning LVC practices. This project aims to investigate how health care professionals account for various factors as they make decisions regarding de-implementation of LVC practices.
Methods

This project will be carried out in two main steps. First, a factorial survey experiment (a vignette study) will be applied to empirically test the relevance of factors previously identified in the literature for health care professionals’ decision-making about de-implementation. Second, interactive workshops with relevant stakeholders will be carried out to develop a framework for professionals’ decision-making and to offer suggestions for interventions to support de-implementation of LVC practices.
Discussion

The project has the potential to contribute to improved understanding of the decision-making involved in de-implementation of LVC practices. We will identify which factors are more important when they make judgments about utilizing versus abandoning LVC practices. The results will provide the basis for recommendations concerning appropriate interventions to support de-implementation decision-making processes.
A Unique RGO Aerogel/TiO2/MoS2 Composite Photocatalyst with a 3D Sandwich Network for the Removal of Organic Dyes by the Cooperative Action of Adsorption and Photocatalysis
Authors: Zhang Yujuan , Qi Haojie , Zhang Liang , Wang Yao , Zhong Lvling , Zheng Yage , Wen Xin , Zhang Xiaomin , Xue Juanqin 
Published: May 2021

Abstract
A unique composite with a three dimensional (3D) sandwich network structure consisting of reduced graphene oxide aerogel/titanium dioxide/molybdenum disulfide (abbreviated as RGO aerogel/TiO2/MoS2) was developed for the removal of organic dyes from solution cooperatively by adsorption and photocatalytic degradation mechanisms. The composite was successfully synthesized by stepwise hierarchical assembly integration, including sol-gel and physical vapor deposition (PVD) methods. The resulting multicomponent composite material featured a high specific surface area (255.441 m2/g) absorption capacity manifested by the myriad negatively charged carboxylate function groups on the surface of the composite. The composite material demonstrated ideal optical and photocatalytic properties, including a large absorbance in the visible light region and a fast transfer of photogenerated electron-hole pairs, resulting in a superb photodegradation performance. The RGO aerogel/TiO2/MoS2 also exhibited a high cationic dyes removal efficiency through the cooperative adsorption and photocatalytic degradation mechanisms. Moreover, electron paramagnetic resonance (EPR) analysis and reactive oxygen species scavenging experiments confirmed that superoxide radicals (O2•−), holes (h+), and hydroxyl radicals (•OH) were involved in photocatalytic degradation of the organic dyes.
Multi-physics Coupling Analysis and Bench Experiment Research of Brake
Authors: Su Xuwu , Cheng Yi , Xia Hailong 
Published: May 2021

Abstract
In order to explore the comprehensive performance of a new type of brake-circular disc brake, a multi-physics coupling analysis was established using ANSYS Workbench software to study the heat generation mechanism and air-cooled heat dissipation effect of the brake under different working conditions. Under the condition of a single braking condition, the maximum temperature of the peripheral disc brake is 98.1℃; under the condition of continuous braking, the maximum temperature of the brake is 170.22℃, and the highest temperature occurs on the outer surface. A thermo-fluid-solid coupling analysis of the peripheral disc brake is established. Compared with the heat generation of a single braking condition, the maximum temperature of the brake is reduced by 14.77℃, which shows that the effect of forced air cooling is not obvious. Use the test bench to compare the finite element analysis results. It can be seen from the bench experiment that as the cyclic braking progresses, the maximum temperature of each braking cycle basically increases in a gradient manner, and the experimental and simulation results are basically consistent. The maximum error between the experiment and the finite element simulation is 8.29℃ , Verified the reliability of finite element analysis.
Differential proMMP-2 and proMMP-9 Secretion in Human Pre-implantation Embryos at Day 5 of Development.
Authors: Olvera-Valencia Mercedes , Acuña-González Ricardo Josué , Iyune-Cojab Esther , Vázquez-Cárdenas Paola , López-Canales Jorge Skiold , Lozano-Cuenca Jair , Osorio-Caballero Mauricio , Flores-Herrera Héctor 
Published: May 2021

Abstract
Background: The most commonly used non-invasive criterion for evaluating the probable success of transferring in vitro human embryos for implantation is their morphological development. With this criterion, however, embryos in cellular arrests go unnoticed. Extracellular matrix metalloproteases type 2 (MMP-2) and MMP-9 are key markers of embryonic development and the implantation process, according to various animal studies. The current study investigated the proMMP-2 and proMMP-9 expression in the culture media developing human embryos that were transferred for implantation. Methods: Forty-two patients were accepted in the Department of Reproductive Biology of a Hospital in México City, based on the Institutional inclusion criteria for in vitro fertilization. On day 5 of development, embryos were transferred to women, and the culture medium was stored at -70 to await assessment of the activity of proMMP-2 and proMMP-9 in substrate gel zymography. Results: The patients showing embryo sac development were assigned to the pregnant group (n =17) or non-pregnant (n =25). In both groups, the activity of proMMP-2 and proMMP-9 was evaluated in substrate gel zymography. Our results indicate for all 17 women able to achieve a full-term pregnancy, the activity band of proMMP-2 was found in the corresponding culture medium. For 11 of them, the band of proMMP-9. Regarding the other 25 patients, the expression band for proMMP-2 detected in 3 and that proMMP-9 in 11 individuals. Conclusions: On day 5 of embryo development, the evaluation of proMMP-2 and proMMP-9 in the embryo culture medium is a reliable indicator of embryo quality and capacity to establish pregnancy.
Improving Prognosis of Surrogate Assay for Breast Cancer Patients by Absolute Quantitation of Ki67 Protein Levels using Quantitative Dot Blot (QDB) Method
Authors: Hao Junmei , Lv Yan , Zou Jiarui , Zhang Yunyun , Xie Shuishan , Jing Lili , Tang Fangrong , Lv Jiahong , Zhang Wenfeng , Zhang Jianbo , Wang Xunting , Chen Kuisheng , Zhang Jiandi 
Published: May 2021

Abstract
Background: Immunohistochemistry (IHC) based-surrogate assay is the prevailing method in daily clinical practice to determine the necessity of cytotoxic therapy for Luminal-like breast cancer patients worldwide. It relies on Ki67 scores to separates Luminal A-like from Luminal B-like breast cancer subtypes. Yet, IHC method is plagued with subjectivity and inconsistency. We attempted to circumvent these issues by measuring Ki67 levels absolutely, quantitatively and objectively.Methods: The Ki67 protein levels in a cohort of 253 specimens were measured with IHC and Quantitative Dot Blot (QDB) methods respectively, and used to assign these specimens into Luminal A-like and Luminal B-like subtypes accordingly. Their performances were compared with the Kaplan-Meier, univariate and multivariate survival analyses of the overall survival (OS) of Luminal-like patients.Results: The surrogate assay based on absolutely quantitated Ki67 levels (cutoff at 2.31 nmole/g) subtyped the Luminal-like patients more effectively than those based on Ki67 scores (cutoff at 14%) (Log rank test, p=0.00052 vs p=0.031). It is also correlated better with OS in multivariate survival analysis [Hazard Ratio (HR) at 6.89 (95%CI: 2.66-17.84, p=0.0001) vs 2.14 (95%CI: 0.89-5.11, p=0.087)].Conclusions: Our study showed the performance of surrogate assay may be improved significantly by measuring Ki67 levels absolutely, quantitatively and objectively.
A new classification for retinitis pigmentosa including multifocal electroretinography to evaluate the disease severity
Authors: Oner Ayse , Kahraman Neslihan Sinim 
Published: May 2021

Abstract
Aim: To establish a useful and objective classification for retinitis pigmentosa (RP) to evaluate the disease severity.Methods: This is a retrospective cross-sectional study. Visual acuity (VA), visual field width, ellipsoid zone width on optic cohorence tomography and multifocal electroretinography values were obtained from medical records of patients with RP. A scoring criterion was developed wherein each variable was assigned a score from 0 to 5 depending on its distribution. The cumulative score (from 0 to 20) was used to classify disease severity from grade 0 to 5. The scores were correlated with each other and the final grade.Results: Data of 152 eyes of 92 patients who had the results of all tests were reviewed. The mean age was 41.2 years. The mean VA of the patients was 0.13±0.16 Snellen lines. The majority of patients had a VA less than 20/40 (88.6%), a visual field smaller than 20° (78%), and an ellipsoid zone width smaller than 7° (84.4%). The majority of the patients (85.4%) were in advanced stage of the disease (Grade 4 and 5). Conclusions: We present a simple, objective and easy to use disease severity classification for RP which can be used to categorise patients and to evaluate and compare treatment results.
Bilateral Retinal Artery Occlusion; A Retrospective Analysis of Clinical Presentation and Management
Authors: Kumar Jayant , Adenuga Olukorede Olusoga , Chhablani Deepesh , Parida Haemoglobin , Muraleedharan Sabareesh , Kannan Naresh B. , Ramasamy Kim 
Published: May 2021

Abstract
Purpose; Retinal artery occlusion (RAO) is an ophthalmologic emergency and involvement of both eyes is rare. The aim of this study was to determine the pattern of presentation of bilateral RAO in south India and the associated systemic disorders.Methods; A retrospective review of the medical records of patients with bilateral RAO seen at a tertiary eye hospital in south India over a period of eight years was carried out. The patients’ demographic and clinical data were extracted from the case files, and analysed using Epi Info statistical software.Results; Six hundred and seventy-four eyes of 662 patients were seen with RAO during the period of the study with 12 (1.8%) patients having bilateral involvement. The mean age of the patients was 58.3 years and males comprised 66.7%. There were 22 (91.7%) eyes with CRAO, and two (8.4%) with branch RAO. Three (25%) patients had simultaneous RAO. The median interval for involvement of the fellow eye was 90 days. Hypertension and diabetes were the most common associated systemic disorders.Conclusion; Bilateral RAO is very rare and usually nonsimultaneous. Patients need to be aware of the possibility of involvement of the fellow eye after a unilateral RAO, and the importance of seeking medical care promptly if this occurs.
Fruit Evaluation of 103 Acerola (Malpighia Emarginata D. C.) Phenotypes from the Subtropical Region of Brazil
Authors: Farinelli Daniela , Silvia Portarena , Silva Daniel Fernandes , Chiara Traini , Menegazzo Silva Giordana , Costa Silva Edvan , Ferreira Veiga Joice , Paola Pollegioni , Fabiola Villa 
Published: May 2021

Abstract
Acerola fruit is one of the richest natural sources of ascorbic acid ever known. As a consequence, acerola fruit and its products are demanded worldwide for the production of health supplements and for the development of functional products. Acerola phenotypes (103) were selected from Western Paraná State and evaluated to obtain information on fruit quality characteristics with the aim of using them in genetic breeding programs for improving acerola in the subtropical region of Brazil. Multivariate analysis of the dissimilarity among the phenotypes was performed using the heat map clustering method and principal component analysis. Results obtained using the two methods were comparable, and the methods were effective in discriminating between samples and variables. This indicates variability among phenotypes with potential for its use in breeding programs. Based on the mean values of the chemical and physical characteristics of fruits and considering the differences among the phenotypes, nine crosses are suggested to generate a future improved population, namely between phenotype numbers 37, 4, 14, 29 and phenotype numbers 99, 60 and 66, belonging to the two different clusters and characterized by high vitamin C content and yield or higher values of fruit size and color parameters.
Impact of Time-of-Flight Reconstructions on Maximum Standard Uptake Value in PET/MRI: Using of 18F-FDG, 11C-CFT and 11C-PIB
Authors: Wimalarathne Dewalage Dilani Neranjana , Ruan Weiwei , Sun Xun , Liu Fang , Hu Fan , Lan Xiaoli 
Published: May 2021

Abstract
Objective: To evaluate the impact of time-of-flight (TOF) reconstruction on the maximum standard uptake value (SUV max) among 18F-FDG, 11C-CFT and 11C-PIB in positron emission tomography/magnetic resonance imaging (PET/MR) brain images.Methods: Suspected Alzheimer’s and Parkinson’s patients (AD/PD) who underwent 18F-FDG, 11C-CFT or 11C-PIB PET-MR imaging were retrospectively included in the study. Each PET LIST mode data was reconstructed with and without TOF respectively using the system default three-dimensional ordered subset expectation maximization iterative reconstruction algorithm (3D-OESM). SUVmax of the selected brain volume of interest (VOI) were measured using the PMOD 3.906 PNEURO module in both TOF and non-TOF images. TOF and non-TOF SUVmax values were assessed by paired t-test and Pearson’s correlation graphs. Contrast improvement of VOIs, relative % SUVmax difference and the percentage signal-to-noise ratio (%SNR) of whole-brain were measured using standard formulas.Results: A total 109 patients were included with the median age (years) and body mass index (BMI-kg/m2) of 62.2±6.8 y and 24.7±2.9 kg/m2 in 11C-PIB (n=34), 60.2±10.9 y and 23.9±3.7 kg/m2 in 11C-CFT (n=41) and 62.3±9.0 y, 23.6±3.5 kg/m2 in 18F-FDG (n=34), respectively. Higher average SUVmax values were observed in all the brain VOIs in TOF compared to non-TOF reconstructions, and relative % average SUVmax difference for all segmented brain VOIs were positive for all three radiotracers. Differences of SUVmax were significant in 100% of segmented VOIs in 18F-FDG (P<0.01), similarly 83.34% of VOIs in 11C-PIB (P<0.05), inversely not in 11C-CFT. Contrast improvement was showed significant (P<0.05) for 60.0%, 66.7% and 50.0% of segmented VOIs in 18F-FDG, 11C-PIB and 11C-CFT in TOF, respectively. %SNR gain for whole-brain showed slightly higher in 11C-PIB and 18F-FDG only in TOF, inequitably difference was significant (P<0.05) in 11C-CFT non-TOF images. TOF versus non-TOF reconstructions were strongly correlated positively and differences were significant (P<0.01) in all the VOIs among three radiotracers. Conclusion: The TOF reconstructions significantly improve the SUVmax value among all the brain VOIs in 11C-PIB, 11C-CFT and 18F-FDG. Consequently, it enhanced image contrast and SNR. Thus, the quantitative effect of TOF reconstruction in simultaneous PET/MRI may positively impact the proper diagnosis of some diseases, such as Alzheimer’s and Parkinson’s diseases.
A Rasch Analysis of the 10-item Kessler Psychological Distress Scale (K10) in the Urban-rural fFinge of China
Authors: Zhu Gaopei , Wang Zhongli , Guan Peixia , Zhu Yuhang , Li Juan , Liu Yujie , Shi Fuyan , Wang Suzhen 
Published: May 2021

Abstract
Background The impact of urbanization on the physical and mental health of the rural-urban population has been ignored. The primary objective of this investigation was to demonstrate the reliability, validity, and responsiveness of the 10-item Kessler Psychological Distress Scale (K10) in the measurement of psychological distress in the rural-urban fringe population. Methods Data were obtained from the mental health section of chronic disease survey in Longzihu District, urban-rural fringe area, of Bengbu City, with 3354 participants. The Mandarin version of K10 was used for face-to-face interviews. The Rasch model was used to analyze the psychometry characteristics and differential item functioning (DIF) of K10.Results Rasch analysis results revealed that the K10 scale showed ordered response categories. The results of principal component analysis (PCA) and information-weighted fit statistic (infit) mean square (MNSQ) indicated that the K10 scale conforms to unidimensionality. The Cronbach's alpha coefficient of K10 was 0.916 (95% confidence interval (CI): 0.907,0.924), which had good reliability, but the Cronbach's alpha coefficient would be increased if the fifth item was removed. The results of the Rasch model showed that all the 10 items in the K10 scale had a good fitting effect (Infit MNSQ value, 0.928-1.072). A non-significant differential item functioning (DIF) was found on K10 of age and gender. Overall, the K10 scale was more difficult, and the psychological distress score of the subjects was generally low.Conclusion Rasch analysis showed that the Mandarin version of K10 was an effective and reliable scale for measuring and screening mental distress of residents in the urban-rural fringe. However, it was still recommended that further research should be conducted to solve inappropriate and difficult items.
Using Probability Distribution Functions to Correlate Breakthrough Curves of Water and air Contaminants
Authors: Chu Khim Hoong 
Published: May 2021

Abstract
This paper reports the use of five probability cumulative distribution functions (normal, log-normal, logistic, Gompertz, and Weibull) to correlate published breakthrough data of water and air contaminants (ciprofloxacin, ammonium, hydrogen chloride, and hydrogen sulfide). Because the shape of the ciprofloxacin breakthrough curve is fairly symmetric, it is well correlated by all five functions (R2 > 0.99). They also provide a good representation of the overall shape of the ammonium breakthrough curve (R2 > 0.99). However, none can describe the leakage of ammonium during the initial period of column operation. The log-normal and Weibull functions give an excellent representation of the tailing HCl data while the normal, logistic, and Gompertz functions are quite poor. This difference in performance can be explained by the different characteristics of their inflection points. The log-normal and Weibull functions have a floating inflection point, which gives them flexibility in tracing the shape of the tailing data. The invariant inflection points of the normal, logistic, and Gompertz curves restrict their data fitting ability. Only the log-normal function can provide a reasonable fit to the H2S data with strong tailing. It is shown that the invariant inflection point of a probability function can be converted to a floating one. A version of the Gompertz function so modified provides a good quantitative correlation of the tailing data of H2S (R2 = 0.99).
Tannery Liming Sludge in Compost Production: Sustainable Waste Management
Authors: Hashem Md. Abul , Sahen Md. Sahariar , Hasan Mehedi , Payel Sofia 
Published: May 2021

Abstract
In tannery at beamhouse, hair burning liming wastewater is the most toxic substance, which has adverse impact on the environment. Treatment of hair burning liming wastewater begets substantial amount of solid waste termed as ‘sludge’. In this investigation, in-situ prepared liming sludge from hair burning liming wastewater is used for compost processing. The liming sludge is mixed with sawdust, cow dung, and chicken manure; piled onto a horizontal bamboo aerator. Three compost piles were built up weighing 650, 690, and 630 Kg. Drastic changes were observed in temperature due to the revolving of the piles. The highest temperature generated in the piles were in the thermophilic range at 59.69°C, 64.41°C, and 63.36°C respectively, ensures the destruction of pathogenic microorganism. The heavy metals Zn, Cu, Cr, Ni, Cd, and Pb of the compost were analyzed and the highest amounts found among the piles were 152.64, 21.20, 21.02, 6.93, 5.78, and 3.30 mg/kg, correspondingly. Moreover, the nutrient nitrogen, phosphorous, potassium, sulfur of the compost fulfills the requirement of the investigated material as compost. SEM analysis indicates the degradation of the composting materials. This study reveals that without any pretreatment, the generated tannery liming sludge can be transformed into a value-added product with the use of a zero-waste approach.
Heat Transfer Analysis of Pin-fin Profiles for Aerospace Application using CFD
Authors: N Manikanda Prabu , P Venkateshwaran , Murali Ganesh 
Published: May 2021

Abstract
Heat transfer is key phenomena of any cooling systems for the safe and satisfactory operating condition of an appliance. Fins are occupying a greater role in cooling of vehicle systems and specifically, radiating fins are used in space vehicles which represents an important part of the satellite thermal control system. The present work assumed three different profiles such as rectangular, stepped and elliptical pin-fins in radiation ambiance. The experiment is conducted in vacuum chamber setup to show the possibilities of heat transfer enhancement in radiating fins by taking those different profiles, also with Computational fluid dynamics. The performance of fins can be depicted in terms of the thermal conductivity and amount of heat transfer which is possible to evaluate from fin’s temperature distribution. However, a temperature dependent thermal conductivity is considered when there is a large temperature difference. Hence, the finite volume method is employed to simulate the temperature distribution due to the lower temperature gradient. The results of experimental and numerical analysis are used to compare the fin profiles for suitability in space vehicles.