bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event‐based impulsive consensus for delayed multi‐agent systems
Authors: Wang Yangling , Cao Jinde , Wang Haijun 
Published: July 2021

AbstractThis paper focuses on the average consensus problem for delayed nonlinear multi‐agent systems. To reduce unnecessary energy consumption, a novel event‐triggered impulsive control mechanism is adopted, in which the impulsive time series is determined by some pre‐designed events. Simultaneously, the Zeno‐behavior of the event‐triggering time series is excluded. By using Lyapunov–Krasovskii functional method as well as impulsive control theory, an easy‐to‐check sufficient criterion is derived to ensure the average consensus of the considered nonlinear multi‐agent systems. Finally, the applications and effectiveness of the obtained results is validated with a simulation example.
Two sensitive characteristics and their overlap with two questions per card
Authors: Xu Tonghui , Sedory Stephen A. , Singh Sarjinder 
Published: July 2021

AbstractIn this paper, we developed a new unique unrelated question randomized response model in which each card has two questions, either both questions on the sensitive characteristics or both questions on the two unrelated characteristics. The proposed model is unique in the sense this is the only way of asking two questions printed on each card that leads to protection of the privacy of the respondent. We first develop estimators of the prevalence of the two sensitive characteristics and of their overlap. Then we show that the resultant estimators are unbiased. Next we derive variance expressions for the developed estimators of the proportions. We also compute the relative efficiency and relative privacy protection of the proposed model with respect to its competitors. The variances of the proposed estimators are also verified by comparing them to the Cramer–Rao lower bounds of variance–covariance of the estimators. Estimators of conditional proportion, relative risk, and correlation coefficient are also discussed. Lastly, a real data application of the proposed model is considered, which shows the importance of the use of the proposed model in medical and social science studies.
MiR‐214‐3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4
Authors: Pang Bo , Qiao Ling , Wang Shaoxin , Guo Xin , Xie Yun , Han Liping 
Published: July 2021

AbstractThis study aimed to investigate the functions of miR‐214‐3p in diabetic neuropathic rodents. The diabetic neuropathy was induced by intraperitoneal injection of streptozotocin (STZ) in rats, and miR‐214‐3p was delivered via tail vein injection of lentivirus. Hot or cold stimulus tests demonstrated that STZ induced thermal hyperalgesia. Neurophysiological measurements revealed that motor and sensory nerve conduction velocity and nerve blood flow were decreased in diabetic neuropathic rats. However, the STZ‐induced hyperalgesia, and reduced nerve conduction velocity and nerve blood flow were all significantly reversed by miR‐214‐3p administration. HE staining, TUNEL, ELISA, and immunoblotting demonstrated that STZ led to obvious pathological lesion, cell apoptosis, and inflammation in dorsal root ganglion (DRG), evidenced by altered levels of apoptosis‐related protein molecules and inflammatory factors, and activation of Toll‐like receptor 4 (TLR4)/myeloid differentiation primary response gene 88/nuclear factor kappa B signaling. The pathological alterations in diabetic neuropathic rats in DRG were significantly ameliorated by miR‐214‐3p application. In addition, sodium channel protein type 3 subunit alpha isoform 1 (Nav1.3) and TLR4 were identified as targets of miR‐214‐3p via dual‐luciferase reporter assay. MiR‐214‐3p may play its roles by downregulating Nav1.3 and TLR4. In summary, miR‐214‐3p alleviated diabetes‐induced nerve injury, and pathological lesion, cell apoptosis, and inflammation in DRG by regulating Nav1.3 and TLR4 in STZ‐induced rats. These findings may provide novel therapeutic targets for clinical treatment of diabetic neuropathy.
A case of severe side effect due to muscle oil injections in combination with chemotherapy in a former bodybuilder
Authors: Gitz‐Johansen Gro , Als Anne Birgitte , Pallesen Kristine Appel Uldall 
Published: July 2021

AbstractThis case report presents an acute painful skin reaction several years after injection of site‐enhancing oils (SEO) induced by chemotherapy. This case exemplifies the long‐term dangerous side effects of the use of SEO, however treatable with prednisolone.
Isolated facial diplegia: A rare presentation of Guillain‐Barre syndrome
Authors: Sardar Sundus , Sasi Sreethish , Menik Arachchige Suresh , Zahid Muhammad , Melikyan Gayane 
Published: July 2021

AbstractThe paper presents a case of bilateral facial nerve palsy and its unique presentation. It discusses the etiologies of bilateral facial nerve palsy. We aim to provide awareness to its presentation, diagnosis, and management.
Primary follicular lymphoma of colon: A case series and review of literature
Authors: Mohammed Abdul , Shariati Farnaz , Paranji Neethi , Waghray Nisheet 
Published: July 2021

AbstractFollicular lymphoma of the colon is rare, accounting for 1% to 2% of cases in the gastrointestinal tract. Despite the absence of randomized clinical trials, NCCN stage III and IV colonic follicular lymphomas are routinely treated with chemotherapy with good clinical response. We present 2 cases of advanced stage follicular lymphoma of colon that were effectively treated with bendamustine‐based chemotherapy regimens.
The confused puzzles in antineutrophil cytoplasmic antibody‐associated vasculitis activity evaluation: A case report
Authors: Zhang Ai‐hua , Yao Wei‐long , Liu Wen‐hu 
Published: July 2021

AbstractAntineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) is a group of chronic multisystem autoimmune diseases with substantial mortality and morbidity and frequent relapses. The complexity of the disease condition and treatment‐related adverse reactions as well as infections play important roles in the poor outcomes. Unfortunately, the subjective symptoms and objective indicators are not fully parallel, and manifestations between disease activity and treatment‐related adverse reactions are often similar. Here, we describe a case of pulmonary mucormycosis in an old female patient with AAV to highlight these challenges.
Complete eradication of chronic lymphocytic leukemia with unusual skin involvement of high mitotic index after time‐limited venetoclax/obinutuzumab treatment
Authors: Dimou Maria , Iliakis Theodoros , Paradalis Vasileios , Bitsani Aikaterini , Kyrtsonis Marie‐Christine , Panayiotidis Panayiotis 
Published: July 2021

AbstractThe novel time‐limited combinations with the bcl‐2 inhibitor venetoclax can induce deep responses even in CLL cases with unusual and biologically aggressive presentations, like the skin masses of our patient.
Dual coronary ‐ cameral fistula “double the trouble”
Authors: Kalavakunta Jagadeesh K. , Sachdev Sarina , Randhawa Mandeep 
Published: July 2021

AbstractA patient presenting with worsening dyspnea and left‐sided chest pain underwent heart catheterization, found to have a rare connection between the right and left coronary arteries draining into the left ventricle, consistent with dual coronary‐cameral fistula.
Lipomatosis of appendix in a teenager
Authors: Shanmugarajah Inthujan , Sundrehagen Bendik H. , Warberg Eivind A. , Kazaryan Airazat M. 
Published: July 2021

AbstractCase of rare diagnosis of lipomatosis of appendix was established based on histologic report of appendicular specimen after laparoscopic appendectomy for suspected appendicitis in 16‐year‐old boy. Application of imaging modality may avoid unnecessary appendectomy.
Stepwise Stress‐Induced Transformations of Metal‐Organic Polyhedral Cluster‐Based Assemblies: Where Conformational and Supramolecular Features Meet
Authors: Terlecki Michał , Sobczak Szymon , Leszczyński Michał K. , Katrusiak Andrzej , Lewiński Janusz 
Published: July 2021

AbstractUnderstanding the factors governing the formation of supramolecular structures and phase transitions between various forms of molecular crystals is pivotal for developing dynamic, stimuli‐responsive materials and polymorph‐controlled syntheses. Here, we investigate the pressure‐induced dynamic of both the intrinsic molecular structure and the supramolecular network of a predesigned polyhedral oxo‐centered zinc cluster incorporating monoanionic N,N’‐diphenylformamidinate and featuring N‐bonded phenyl groups in close proximity to the primary coordination sphere. We demonstrate that the model oxo cluster is prone to undergoing pressure‐induced conformational transformations of the secondary coordination sphere and simultaneous stepwise (initially every second polyhedral molecule undergoes the conformational transformations) and reversible transitions from an ambient phase α to high‐pressure phases β and γ, as single‐crystal‐to‐single‐crystal events. The observed phase transitions illustrate the key role of an interplay between the low‐energy conformation perturbations and cooperative intra‐ and intermolecular noncovalent interactions.
Stimulation of Ca2+‐ATPase Transport Activity by a Small‐Molecule Drug
Authors: Sordi Giacomo , Goti Andrea , Young Howard S. , Palchetti Ilaria , Tadini‐Buoninsegni Francesco 
Published: July 2021

AbstractThe sarco(endo)plasmic reticulum Ca2+−ATPase (SERCA) hydrolyzes ATP to transport Ca2+ from the cytoplasm to the sarcoplasmic reticulum (SR) lumen, thereby inducing muscle relaxation. Dysfunctional SERCA has been related to various diseases. The identification of small‐molecule drugs that can activate SERCA may offer a therapeutic approach to treat pathologies connected with SERCA malfunction. Herein, we propose a method to study the mechanism of interaction between SERCA and novel SERCA activators, i. e. CDN1163, using a solid supported membrane (SSM) biosensing approach. Native SR vesicles or reconstituted proteoliposomes containing SERCA were adsorbed on the SSM and activated by ATP concentration jumps. We observed that CDN1163 reversibly interacts with SERCA and enhances ATP‐dependent Ca2+ translocation. The concentration dependence of the CDN1163 effect provided an EC50=6.0±0.3 μM. CDN1163 was shown to act directly on SERCA and to exert its stimulatory effect under physiological Ca2+ concentrations. These results suggest that CDN1163 interaction with SERCA can promote a protein conformational state that favors Ca2+ release into the SR lumen.
LYTACs: An Emerging Tool for the Degradation of Non‐Cytosolic Proteins
Authors: Ramadas Bhavana , Kumar Pain Pritam , Manna Debasish 
Published: July 2021

AbstractIn the last two decades, targeted protein degradation has rapidly gained popularity as a technique to eliminate disease‐causing undruggable proteins. Over the years, many tools have been devised to degrade proteins by exploiting natural protein homeostasis machinery available in our body, with LYTACs being the latest to come on board. LYTACs, or lysosome‐targeting chimeras, make use of the lysosome degradation pathway by recruiting proteins to lysosome‐shuttling receptors located at the cell surface. LYTACs are specifically meant for the degradation of membrane‐bound and extracellular proteins, which account for the products of 40 % of all protein‐encoding genes. In this highlight, we describe two studies that demonstrate the scope of LYTACs and its advantages over the other protein degradation platforms. In the first study, the LYTAC utilizes the cation‐independent mannose‐6‐phosphate receptor (CI−M6PR), while the second study uses the asialoglycoprotein receptor (ASGPR) which is found only on the surface of liver cells.
Compression and load balancing for efficient sparse matrix‐vector product on multicore processors and graphics processing units
Authors: Aliaga José I. , Anzt Hartwig , Grützmacher Thomas , Quintana‐Ortí Enrique S. , Tomás Andrés E. 
Published: July 2021

SummaryWe contribute to the optimization of the sparse matrix‐vector product by introducing a variant of the coordinate sparse matrix format that balances the workload distribution and compresses both the indexing arrays and the numerical information. Our approach is multi‐platform, in the sense that the realizations for (general‐purpose) multicore processors as well as graphics accelerators (GPUs) are built upon common principles, but differ in the implementation details, which are adapted to avoid thread divergence in the GPU case or maximize compression element‐wise (i.e., for each matrix entry) for multicore architectures. Our evaluation on the two last generations of NVIDIA GPUs as well as Intel and AMD processors demonstrate the benefits of the new kernels when compared with the optimized implementations of the sparse matrix‐vector product in NVIDIA's cuSPARSE and Intel's MKL, respectively.
Utilizing ensemble learning for performance and power modeling and improvement of parallel cancer deep learning CANDLE benchmarks
Authors: Wu Xingfu , Taylor Valerie 
Published: July 2021

AbstractMachine learning (ML) continues to grow in importance across nearly all domains in modeling to learn from data. Often a tradeoff exists between a model's ability to minimize bias and variance. In this article, we utilize ensemble learning to combine linear, nonlinear, and tree‐/rule‐based ML methods to cope with the bias‐variance tradeoff and result in more accurate models. We use the datasets collected for two parallel cancer deep learning CANDLE benchmarks, NT3 and P1B2, to build performance and power models based on hardware performance counters using single‐object and multiple‐objects ensemble learning to identify the most important counters for improvement on the Cray XC40 Theta at Argonne National Laboratory. Based on the insights from these models, we improve the performance and energy of P1B2 and NT3 by optimizing the deep learning environments TensorFlow, Keras, Horovod, and Python under the huge page size of 8 MB. Experimental results show that ensemble learning not only produces more accurate models but also provides more robust performance counter ranking. We achieve up to 61.15% performance improvement and up to 62.58% energy saving for P1B2 and up to 55.81% performance improvement and up to 52.60% energy saving for NT3 on up to 24,576 cores.
Improved access to the bone marrow space by multiple perforations of the alveolar bundle bone after tooth extraction—A case report
Authors: Ulm Christian , Strbac Georg D. , Stavropoulos Andreas , Esfandeyari Azadeh , Dobsak Toni , Bertl Kristina 
Published: July 2021

AbstractObjectivesThe dental alveolus is lined by a thin cortical layer (“bundle bone”, “alveolar bone proper”, “cribriform plate”, “lamina dura”), that can impede access to the bone marrow and its vasculature. During unassisted socket healing, the alveolar bundle bone is gradually resorbed allowing tissue resources from the bone marrow to enter into the socket space. An optimized wound healing process, either during unassisted socket healing or during ridge preservation procedures, with autogenous bone and/or any bone/collagen substitute material, depends at least partly on an adequate vascularization of the socket space. This ensures sufficient recruitment of osteoblast and osteoclast precursor cells and facilitates fast bone regeneration and/or uneventful integration of the augmentation material.MethodsThe present technical note describes an easy treatment step after tooth extraction aiming to improve socket healing with or without any ridge preservation procedure, by facilitating an increased blood inflow into the dental alveolus. Specifically, after tooth extraction the alveolar bundle bone is perforated several times – mainly in a palatally/lingually – by a small round bur (diameter < 1 mm) extending into the trabecular bone.Results and conclusionsBy means of this relatively simple treatment step, an increased blood inflow into the alveolus is achieved after tooth extraction, which might enhance socket healing and corticalization of the entrance, and in turn result in a lower complication rate (e.g., dry socket), in an enhanced graft incorporation, and/or in a reduced loss of alveolar ridge volume.
Design of high‐isolation and low‐loss single pole double throw switch based on the triple‐coupled transformer for ultra‐wideband phased array systems
Authors: Wang Zeyuan , Li Zhenrong , Wang Yuxin , Li Zhen , Zhuang Yiqi 
Published: July 2021

AbstractThis paper proposes a single pole double throw (SPDT) switch based on the triple‐coupled transformer. The triple‐coupled transformer utilizes a novel structure with three stacked coupled inductors which are placed in nonconcentric positions to ensure the isolation of SPDT switch. The SPDT switch obtains additional optimization space to improve insertion loss performance under the premise of reassuring isolation. The equivalent circuit model is built to interpret the mechanism of the SPDT switch and transformer. The proposed switch is implemented with the 65‐nm CMOS process, the simulated results show the isolation between input‐to‐output ports are better than 25 dB at 24–38 GHz. The proposed SPDT switch achieves a minimum insertion loss of 1.56 dB with compact chip size 625 × 370 μm2 (with PADs).
Effects of camera‐trap placement and number on detection of members of a mammalian assemblage
Authors: Hofmeester Tim R. , Thorsen Neri H. , Cromsigt Joris P. G. M. , Kindberg Jonas , Andrén Henrik , Linnell John D. C. , Odden John 
Published: July 2021

AbstractA central goal in camera‐trapping (CT) studies is to maximize detection probability and precision of occupancy estimates while minimizing the number of CTs to reduce equipment and labor costs. Few studies, however, have examined the effect of CT number on detection probability. Moreover, historically, most studies focused on a specific species and the design could be tailored toward maximizing detection of this target species. Increasingly, however, such studies use data for all captured, non‐target, species (by‐catch data) for animal community‐level analyses. It remains unclear if, and how, the targeting of CTs toward one species affects the detection of non‐target species. We paired CTs from a permanent camera‐trapping grid (with 38 CTs) targeted at monitoring Eurasian lynx (Lynx lynx) in Innlandet County, Norway, with additional randomly placed CTs at two spatial scales (38 CTs within the same habitat patch and 38 CTs within the same 50‐km2 grid cell as the lynx‐targeted CTs) for three months. We combined multi‐scale occupancy models that enable the separation of large‐scale occupancy, CT‐scale site use, and detection probability with single‐scale occupancy models. This allowed us to study the effects of targeted placement and CT number on the detection probability of the target species (lynx) and seven non‐target mammal species (four carnivores, three herbivores, and one rodent). We found that all species, except moose (Alces alces), had the highest detection probability at lynx‐targeted CTs. Moose had equal detection probabilities at all three placement types. Adding extra CTs generally increased detection probabilities. Consequently, for all species, combining a lynx‐targeted CT with one or more randomly placed CTs, increased the accuracy and precision of occupancy estimates for 50‐km2 grid cells compared to single CT estimates. The placement of single CTs underestimated grid‐cell occupancy compared to known minimum occupancy and were similar to site‐use probability estimates of multi‐scale models. It is, however, uncertain to which spatial extent these site‐use probabilities refer. We therefore recommend the use of multiple (targeted) CTs to estimate occupancy in large grid cells and to interpret occupancy estimates from single CTs as site use of an, as of yet undefined, area surrounding the CT.
Right coronary artery diastolic perfusion pressure on outcome of patients with left heart failure and pulmonary hypertension
Authors: Hamud Amir , Brezins Marc , Shturman Alexander , Abramovich Adrian , Dragu Robert 
Published: July 2021

AbstractAimsRight ventricle adaptation to prolonged exposure against pulmonary hypertension (PH) includes structural and functional abnormalities, translated into modifications of blood flow pattern through the right coronary artery. Given these changes, we investigate the relationship between right coronary artery diastolic perfusion pressure (RCDPP) and clinical outcome, in patients with PH secondary to left‐sided heart failure (HF).Methods and resultsWe studied 108 HF patients who underwent right heart catheterization. PH was present in 75 (69.4%). Mean RCDPP was lower in patients with PH (59.4 ± 14.0 mmHg) as compared with no PH patients (65.5 ± 11.6 mmHg) (P = 0.03). Aortic diastolic pressure accounted for 79% of RCDPP variability explained by the model (P < 0.0001). During a median follow‐up of 26 months, the RCDPP 1st tertile (<55 mmHg) [hazard ration (HR) 5.19, 95% confidence interval (CI) 1.08–25.12, P = 0.04] and left ventricular ejection fraction <45% [HR 7.26, 95% CI 1.77–29.73, P = 0.006] were independent predictors of mortality.ConclusionsRight coronary artery diastolic perfusion pressure is a strong independent haemodynamic maker of mortality in left‐sided HF and PH. Excessive reduction of aortic diastolic pressure may be detrimental. Future research is necessary to determine the therapeutic approach to blood pressure in this population.
Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole‐body‐irradiated mice
Authors: D'Auria Vieira de Godoy Paulo Roberto , Nakamura Ayumi , Khavari Ali Pour , Sangsuwan Traimate , Haghdoost Siamak 
Published: July 2021

AbstractIt is well‐known that the cytotoxicity and mutagenic effects of high dose rate (HDR) ionizing radiation (IR) are increased by increasing the dose but less is known about the effects of chronic low dose rate (LDR). In vitro, we have shown that in addition to the immediate interaction of IR with DNA (the direct and indirect effects), low doses and chronic LDR exposure induce endogenous oxidative stress. During elevated oxidative stress, reactive oxygen species (ROS) react with DNA modifying its structure. Here, BL6 mice were exposed to IR at LDR and HDR and were then sacrificed 3 hours and 3 weeks after exposure to examine early and late effects of IR. The levels of micronuclei, MN, were determined in bone marrow cells. Our data indicate that the effects of 200 mGy on MN‐induction are transient, but 500 and 1000 mGy (both HDR and LDR) lead to increased levels of MN up to 3 weeks after the exposure.
Treatment of intermediate landfill leachate using different anode materials in electrooxidation process
Authors: Can Orhan Taner , Gazigil Leyla , Keyikoglu Ramazan 
Published: July 2021

AbstractThis study aims to investigate the performances of widely used anode materials in the treatment of intermediate landfill leachate treatment by electrooxidation (EO) process. The raw leachate was collected from an 8‐year‐old landfill facility and had a chemical oxygen demand (COD) of 4660 mg/L, biological oxygen demand (BOD5) of 1370 mg/L, and total organic carbon (TOC) of 2260 mg/L. TOC and COD removal efficiencies of Boron‐Doped Diamond (BDD), Pt, and four different Ti‐based mixed metal oxide (MMO) anodes ((RuO2–TiO2, RuO2–IrO2, PtO2–IrO2, and IrO2–Ta2O5) were compared at the current densities of 25 mA/cm2, 75 mA/cm2, and 125 mA/cm2. At the highest current density, the BDD achieved 100% TOC and COD removal efficiencies in 240 min. BDD was followed by the Pt anode, which achieved 95.53% COD and 92.74% TOC removal efficiencies. The Pt electrode also had the lowest SEC values at all current densities. Although the performances of four MMO electrodes were very close, RuO2–TiO2 achieved a slightly higher performance than the others. It was concluded that Pt anode can be a promising alternative to BDD, which was 18 times more expensive, with its comparable pollutant removal performance and low specific energy consumption.