bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of myocardial MIBI washout rate in risk stratification of coronary artery disease
Authors: Othman Mohammed Omar Mohammed , Moustafa Hosna Mohammed , El-Ghany Mohammed Mahmoud Abd , El-Mon’em El-Rasad Shaimaa Ahmed Abd 
Published: March 2021

Abstract
Background
Although it is well established that MIBI does not redistribute as thallium within the myocardium, it showed a reverse redistribution phenomenon that can be expressed by the rate of myocardial MIBI washout. The aim in this study was calculating the global myocardial washout of the MIBI (GWR) in patients diagnosed with coronary artery disease (CAD) of different risk stratifications.

Results
This prospective study included 100 patients. All patients were stratified into low-, intermediate-, and high-risk groups according to clinical evaluation using Framingham score, stress ECG results using Duke’s score and finally myocardial perfusion imaging prognostic findings. GWR was estimated in each of these groups. GWR mean was 9.5%, 13%, and 18% within clinically stratified patients into low-, intermediate-, and high-risk patients respectively with correlation coefficient 0.4. In addition, GWR mean was 9.7%, 15.4%, and 18.7% within patients stratified according to exercise ECG findings into low-, intermediate-, and high-risk patients respectively with correlation coefficient 0.6. Combining all myocardial perfusion findings, GWR mean was 7.9%, 15.1%, and 19.3% in patient with low-, intermediate-, and high-risk imaging findings respectively with correlation coefficient 0.71.

Conclusion
GWR is positively correlated with the risk stratifications of the CAD patients. GWR can be used as an additional parameter to assess the risk of CAD patients.
Patient educational level and management of bipolar disorder
Authors: Karanti Alina , Bublik Lana , Kardell Mathias , Annerbrink Kristina , Lichtenstein Paul , Runeson Bo , Pålsson Erik , Landén Mikael 
Published: March 2021

Background
Socioeconomic factors can affect healthcare management.

Aims
The aim was to investigate if patient educational attainment is associated with management of bipolar disorder.

Method
We included patients with bipolar disorder type 1 (n = 4289), type 2 (n = 4020) and not otherwise specified (n = 1756), from the Swedish National Quality Register for Bipolar Disorder (BipoläR). The association between patients’ educational level and pharmacological and psychological interventions was analysed by binary logistic regression. We calculated odds ratios after adjusting for demographic and clinical variables.

Results
Higher education was associated with increased likelihood of receiving psychotherapy (adjusted odds ratio 1.34, 95% CI 91.22–1.46) and psychoeducation (adjusted odds ratio 1.18, 95% CI 1.07–1.46), but with lower likelihood of receiving first-generation antipsychotics (adjusted odds ratio 0.76, 95% CI 0.62–0.94) and tricyclic antidepressants (adjusted odds ratio 0.76, 95% CI 0.59–0.97). Higher education was also associated with lower risk for compulsory in-patient care (adjusted odds ratio 0.79, 95% CI 0.67–0.93).

Conclusions
Pharmacological and psychological treatment of bipolar disorder differ depending on patients’ educational attainment. The reasons for these disparities remain to be explained.
Changing practice: assessing attitudes toward a NICE-informed collaborative treatment pathway for bipolar disorder
Authors: Elliott Adele Louise , Watson Stuart , Dodgson Guy , Cohen-Tovée Esther , Ling Jonathan 
Published: March 2021

BackgroundBipolar disorder is a chronic mental health condition, which can result in functional impairment despite medication. A large evidence base supports use of psychological therapies and structured care in the treatment of mood disorders, but these are rarely implemented. e-Pathways are digital structures that inform and record patient progress through a healthcare system, although these have not yet been used for bipolar disorder.AimsTo assess the perceived benefits and costs associated with implementing a collaborative NICE-informed e-pathway for bipolar disorder.MethodHealthcare professionals and people with bipolar disorder attended a workshop to share feedback on e-pathways. Data were collected through questionnaires (n= 26) and transcription of a focus group, analysed qualitatively by a framework analysis.ResultsPatients and healthcare professionals welcomed the development of an e-pathway for bipolar disorder. There were five elements to the framework: quality and delivery of care, patient–clinician collaboration, flexibility and adaptability, impact on staff and impact on healthcare services.ConclusionsIdentification of benefits and costs ensures that future development of e-pathways addresses concerns of healthcare professionals and people with bipolar disorder, which would be essential for successful implementation. Recommendations for this development include making e-pathways less complicated for patients, ensuring sufficient training and ensuring clinicians do not feel their skills become invalidated. Limitations of the study, and directions for future research, are discussed.
Spenser’s Youth
Authors: Wilson-Okamura David 
Published: March 2021

AbstractEpics modeled on the Odyssey typically include a version of Homer’s Circe episode. Edmund Spenser’s variant, the Bower of Bliss, is unusual for ending in physical violence so pronounced that many readers have taken against its putative hero, Sir Guyon. This essay reviews the role of magic in similar episodes to show the enormity of Spenser’s seemingly conservative storytelling. It also defends Spenser’s hero from charges of intemperance and immaturity. The question of intemperance stems from misunderstanding Aristotle. That of immaturity is more complicated. In the economy of justice, youth counteracts complacency. One of Guyon’s prototypes, the biblical king Josiah, is an example. Spenser pictures all his heroes as young, and growing up is part of his design for the epic as a whole. His attitude, though, is not condescending. The danger of sexual indulgence, which Guyon’s critics sometimes dismiss, is one that the epic tradition took seriously and that Spenser himself connected with the recent downfall of public figures.
Construction of Boronate-Affinity Magnetic Immunity SERS Sensor and Detection of Alpha-Fetoprotein (AFP) in Human Serum
Authors: He Yuhan , Li Lijun , Li Xiaoxuan , Lin Chubing , Zhang Yan 
Published: March 2021

Abstract
According to its characteristics, borate can recognize and adsorb target glycoproteins and specific binding properties of antigens and antibodies. This article introduces a preparation method for a magnetic immune SERS sensor, and it is used for the specific identification and detection of trace AFP in human serum. The test used AFP as the target protein and 4-mercaptophenylboronic acid (4-MPBA) modified gold-coated silver nanoparticles (Ag@AuNPs) as the signal factor. After the AFP antibody was grafted on the boric acid group, the SERS detection probe (Ag@Au@4-MPBA@Anti-AFP) was obtained. On the surface of boric acid-functionalized (-P) magnetic silica particles, AFP antibody was modified, and the particles were used as magnetic immunocapture probes (Fe3O4@SiO2-P@Anti-AFP). Finally, the sandwich structure complex of “detection probe-target protein-capture probe” was successfully constructed. The prepared magnetic immune SERS sensor exhibits excellent selectivity and high sensitivity for AFP detection; based on the signal-to-noise ratio S/N = 3, the detection limit can reach 1.0 ng/mL; by performing a spike test on AFP in human serum, the sensor can be used to detect AFP in actual samples. The recovery rate was between 85.8% and 105.7%, and the RSD distribution was ≤3.52%. The sensor was easy to prepare, required no complex processing of samples and can achieve rapid detection, so that it is expected to become a new strategy for clinical detection of AFP.
Bilevel Integer Programs with Stochastic Right-Hand Sides
Authors: Zhang Junlong , Özaltın Osman Y. 
Published: March 2021

We develop an exact value function-based approach to solve a class of bilevel integer programs with stochastic right-hand sides. We first study structural properties and design two methods to efficiently construct the value function of a bilevel integer program. Most notably, we generalize the integer complementary slackness theorem to bilevel integer programs. We also show that the value function of a bilevel integer program can be characterized by its values on a set of so-called bilevel minimal vectors. We then solve the value function reformulation of the original bilevel integer program with stochastic right-hand sides using a branch-and-bound algorithm. We demonstrate the performance of our solution methods on a set of randomly generated instances. We also apply the proposed approach to a bilevel facility interdiction problem. Our computational experiments show that the proposed solution methods can efficiently optimize large-scale instances. The performance of our value function-based approach is relatively insensitive to the number of scenarios, but it is sensitive to the number of constraints with stochastic right-hand sides.Summary of Contribution: Bilevel integer programs arise in many different application areas of operations research including supply chain, energy, defense, and revenue management. This paper derives structural properties of the value functions of bilevel integer programs. Furthermore, it proposes exact solution algorithms for a class of bilevel integer programs with stochastic right-hand sides. These algorithms extend the applicability of bilevel integer programs to a larger set of decision-making problems under uncertainty.
Stability Analysis of Spools with Imperfect Sealing Gap Geometries
Authors: Rituraj Rituraj , Scheidl Rudolf 
Published: March 2021

Spools in hydraulic valves are prone to sticking caused by unbalanced lateral forces due to geometric imperfections of their sealing lands. This sticking problem can be related to the stability of the coaxial spool position. Numerical methods are commonly used to study this behaviour. However, since several parameters can influence the spool stability, parametric studies become significantly computationally expensive and graphical analysis of the numerical results in multidimensional parameter space becomes difficult.
To overcome this difficulty, in this work, an analytical approach for studying the stability characteristics of the spool valve is presented. A Rayleigh-Ritz method is used for solving the Reynolds equation in an approximate way in order to determine an analytical expression for the lateral force on the sealing lands. This analytical expression allows stability analysis of the spool via analytical means which finally results in the expression of critical axial velocity which demarcates the regions of stable behaviour. Simplicity of the expression allows an immediate insight into the role of design parameters in the stability of the spool. To verify the analytical model, a numerical model for spool dynamics is developed in this work and the numerical results are found to match the analytical model in terms of the stability behaviour of the spool.
Effects of Paclobutrazol on Growth and Antioxidant Content of Brassica Rapa Var. Oleifera
Authors: Yusop Z , Y Tsan F , M Jusoh J , S Sahmat S 
Published: March 2021

The experiment was conducted with the main objective was to study the effects of Paclobutrazol (PBZ) on growth and antioxidant content of Brassica rapa var. oleifera. The PBZ was applied at various concentrations (0, 5, 10, 15 and 20 mg /L) through seed soaking and seedling as soil drenching. The growth performance data collection was conducted on weekly basis starting from week 3 until week 6 of planting while antioxidant content analyses were conducted on day 38. It was found that PBZ affected the growth and antioxidant content of Brassica rapa var. oleifera. The soil drenching techniques was found significantly affect the plant height, number of leaves and internode length. Similarly, both ascorbic acid and phenolic content were significantly affected by the technique. It was found that application of 10mg/L and 5mg/L of PBZ has recorded highest amount of ascorbic acid and phenolic content, respectively. This study has proven that the application of PBZ using soil drenching technique on Brassica rapa var. oleifera has contributed to enhancement of its antioxidant content which is also one of the important component in healthy diet intake.Â Â
Isolation and Molecular Identification of Biosurfactant Producing Soil Bacteria
Authors: A N Zamani N , E Tengku Zainal Mulok T , Mat Nor R , . . 
Published: March 2021

Biosurfactants are amphiphilic compound, having hydrophilic and hydrophobic moieties enabling them to reduce surface and interfacial tension at the surface. Their unique properties are applied in various industries such as foaming and wetting agents, emulsifiers, detergents and bioremediation. A total of 98 isolates showed biosurfactant activity using hemolytic activity, drop collapse test and oil spreading assay. All isolates were rod-shaped, Gram positive and majority of them were non-endospore former. Only the isolates showing the highest percentage of emulsification index (E24) and ability to reduce tension were used for species identification using 16S rDNA gene sequencing which were isolates A1(6) and A2(1). Both isolates were identified as Bacillus sp. cp-h50 and Bacillus sp. XT-24 respectively, rod-shaped, endospore former and Gram positive. The biosurfactant produced by both species showed high emulsification index (E24) (A1(6), 63.3% and A2(1), 46.7%) and good surfactant capacity. The size of amplified gene of 16S rDNA gene was approximately 1.5 kb. These features provide evidence that both species could be a potential biosurfactant producer with proper optimization for the production of biosurfactant. The biosurfactant produced by both bacterial species were identified as surfactin using Fourier Transform Infrared Spectroscopy (FTIR).Â Â
Diversity and Distribution of the Mangrove Gastropods of Kuala Selangor Nature Park, Selangor
Authors: Jahid A , R Singh H 
Published: March 2021

This study reports on the diversity and distribution of mangrove gastropods from Kuala Selangor Nature Park sampled from August to November 2017. The line transect with quadrat method was employed to sample gastropods which were handpicked from the various mangrove structures (root, stem, branch) and mangrove floor within 5m x 5m quadrats. Nineteen gastropod taxa were recorded from the Bruguiera, mixed (Bruguiera, Avicennia & Rhizophora), and Avicennia & Rhizophora zones. The Ellobiidae (Elobium aurisjudae and Cassidula aurisfelis), Potamidae (Cerithedia obtusa, Cerithidea cingulata and Telescopium telescopium), Muricidae (Chicoreus capucinus) and Naticidae (Nerita balteata) were the most distributed gastropod families at the study site. Gastropod horizontal distribution varied between tree zones (Bruguiera; Bruguiera-Avicennia-Rhizophora; and Avicennia-Rhizophora) and tree type (Brugueira, Rhizophora and Avicennia), while gastropod vertical distribution varied based on height on tree (0 â€“ 120cm) and sub-habitats (roots, floor and trunk) as shown by the principle components analysis (PCA) biplots. The Margalefâ€™s species richness (D=2.90) and Shannon-Weiner diversity (Hâ€™=2.32) was low which is typical of mangroves that are mature while Pielouâ€™s evenness (J=0.77) was high implying lack of dominance by specific gastropod taxa.Â Â
Anti-Acetylcholinesterase, Anti-Inflammatory and Anti-Oxidant Activities of Raw-Extract Centella Asiatica (RECA) on Lipopolysaccharide (LPS)-Induced Neuroinflammation Sprague Dawley Rats
Authors: Hafiz Z , Shamsuddin N , M Mukhtar S , J James R , I Adenan M 
Published: March 2021

The present study was designed to investigate the potential of raw-extract of Centella asiatica (RECA) in suppressing acetylcholinesterase (AChE), inflammations and oxidative stress via induction of lipopolysaccharide (LPS) on animal model of Sprague Dawley rats. Centella asiatica is a plant thatÂ has been used as a traditional herbal remedy for the management of several diseases, including memory improvement, treatment of mental fatigue and wound healing. Pre-treatment with RECA in vitro significantly reduced the AChE activity in a concentration-dependent manner with IC50 value of 57.47 Â± 13.55 Âµg/ml. Interestingly, this result was parallel with in vivo studies. Moreover, the level of pro-inflammatory cytokines and oxidative stress were significantly reduced by RECA in dose-dependent manner. Overall, our findings clearly dictate the potential of RECA as AChE inhibitor as well anti-inflammatory and anti-oxidant agents.Â
Potential Use of Jackfruit (Artocarpus Heterophyllus) and Breadfruit (Artocarpus Altilis) as Fat Replacer to Produce Low-Fat Chicken Patties
Authors: Rashedi Ismail-Fitry Mohammad , Farihah Azwa Abas Nur 
Published: March 2021

Commercial chicken patties contain high fat, which could affect consumersâ€™ health. Jackfruit (Artocarpus heterophyllus) and breadfruit (Artocarpus altilis) may have the potential to be used as the fat replacer in the chicken patties.Â This study aimed to evaluate the low-fat chicken patties produced by replacing the fat with jackfruit (JF) or breadfruit (BF) at 0% (control), 50% and 100%. The samples were analysed in terms of water holding capacity (WHC), cooking yield (CY), proximate analysis, colour, texture properties, and sensory parameters. Both BF and JF showed higher value (p<0.05) for WHC, moisture content and protein compared to the control. BF (100%) and JF (100%) were recorded of having significantly reduced fat (p<0.05) at 1.80% and 2.23%, respectively. BF showed higher L*(lightness) and b*(yellowness) values significantly (p<0.05) compared to the control. Not many significant differences (p>0.05) between the control and newly formulated chicken patties texture based on the hardness, cohesiveness, and chewiness recorded, proving that BF and JF did not affect the patties texture. Overall, the sensory evaluation of BF (100%) was preferred by the consumer in terms of appearance, texture, flavour, juiciness, and aroma. Thus, BF (100%) can be considered as the best fat replacer in this study.Â Â
Effect of Pre-Treatment on the Morphology and Chemical Properties of Polyethylene Terephthalate (PET)/Pineapple Leaf Fiber (PALF) Electrospun Mat
Authors: N Surip S , M A Aziz F , H Yuwono A , Sofyan N 
Published: March 2021

In the past decades, conventional petroleum-based plastics have resulted in environmental and sustainability issues. Thus, there has been significant interest in the utilization of natural materials for nanofibers product such as for filtration media.Â However, poor compatibility exists between polymers and natural fibers due to natural fibers hydrophilic properties leading to poor nanofibers formation. In this study, Pineapple Leaf Fiber (PALF) remarkable properties were explored. PALF undergo alkaline treatment and bleaching treatment in order to improve its compatibility. Thermal, morphology and structural properties of PALF raw (PR), PALF after alkali treatments (PA) and PALF after alkali + bleaching treatment (PB) were studied. Further, all the samples were diluted using Trifluoroacetic Acid (TFA) as the solvent and Polyethylene Terephthalate (PET) as the polymer carrier and proceed to electrospinning to produce a nanofibers electrospun mats. The electrospun mats were then characterized in terms of its chemical properties using Fourier transform infrared spectroscopy (FTIR) as well as the morphology which using Fields Emission Scanning Electron Microscopy (FESEM).Â FTIR result shows the electrospun PET does not produce any peak at ~3400cm-1 due to its hydrophobic properties. Nevertheless, with addition of PALF, the peak was significantly increased. FESEM results indicated that the present of fibers led to a tendency of lower average fiber diameter compared to the neat PET. Unconnected and thin fibers were coexited from single fiber of PALF raw electrospun indicated that new fibers were ejected however the bond were collapsed during ejection thus did not produce a complete single fiber. Despite that, more uniform fibers of electrospun mat were produced by pre-treatment of PALF.Â
Mechanical Characterization of Aluminium-Silicon-Titanium Diboride (Al-Si-TiB2) Reinforced by Scandium (Sc) and Strontium (Sr)
Authors: N.A. Basir N. , H. Mustafa N. , E. Ibrahim R. , Rosmamuhamadani R. , M. Mahat M. , M. Yahaya Sabrina , K. Talari M. 
Published: March 2021

Aluminium based metal matrix composites (MMCs) have better properties and performance. They are commonly used in transport applications which require combinations of high strength and ductility. They are quite attractive due to their low density, capability to be strengthened by precipitation, good corrosion resistance, high thermal and electrical conductivity. Grain refinement plays a crucial role in improving characteristics and properties of aluminium-silicon (Al-Si) alloy. In this investigation, scandium (Sc) and strontium (Sr) elements were added to aluminium-silicon-titanium diboride (Al-Si-TiB2) alloy for refinement of grains. The compositions of 93 wt.% Al-Si, 6 wt.% TiB2, 0.5 wt.% Sc and 0.5 wt.% Sr were melted into induction furnace. Then the composites have been characterized on the mechanical properties and microstructure characterization. Instron tensile machine and vickers hardness tester were used to characterize the mechanical properties of the composite alloy. Microstructure and phase composition were characterized by Field Emission Scanning Electron Microscope (FESEM) and X-ray Diffraction (XRD). From the results obtained, addition of Sc and Sr, into Al-S-TiB2 improved the tensile strength and hardness of composite alloy. Results also showed that the inoculants addition able to enhance the refinement of grains and escalate the values of hardness and tensile strength of Al-Si-TiB2 composite. Mechanical properties related much on the microstructure as it can be seen that the addition of grain refiners produced much higher value of mechanical properties.Â Â
Dyeability of Red Cabbage Colorant on Silk Fabric Treated With Entada Spiralis Extracts
Authors: Mat Shom N. , I.A. Kadir M. , R. Ahmad M. 
Published: March 2021

Of late, dyeing fabrics with natural colorants have been the attention of the industry. Natural colorants especially from plants have the advantage of being friendly towards the environment as the extraction, processing and dyeing procedures are considered green and safe. However, most natural dyes have poor colourfastness and needed mordants to improve their dyeability. In this study, the addition of Entada spiralis was utilized as a surface modifier to improve dyeability on 100% silk fabrics using extracts from red cabbage. The plant serves as a surface-active agent to reduce the surface tension of the fabrics. The surfactant is also a natural resource and therefore is not harmful to the environment. The Entada spiralis was extracted through boiling for 30 minutes on a hot plate before treating the extracts on the fabrics. During dyeing, lime was used as the mordant simultaneously with dyeing. The dyed fabrics were evaluated for colorfastness to washing, rubbing/crocking and perspiration using the Gray Scale Standard. In addition, the dyed fabrics were also measured for their colour strength, colour coordinates and % reflectance. The results showed that dyed fabrics with Entada spiralis have darker shades in comparisons with the untreated fabric.Â Â