bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Intervention by and for Transgender Women Living With HIV: Study Protocol for a Two-Arm Randomized Controlled Trial Testing the Efficacy of “Healthy Divas” to Improve HIV Care Outcomes
Authors: Sevelius Jae M. , Neilands Torsten B. , Reback Cathy J. , Castro Danielle , Dilworth Samantha E. , Kaplan Rachel L. , Johnson Mallory O. 
Published: October 2021

Introduction:Transgender women (assigned “male” at birth but who do not identify as male) are disproportionately impacted by HIV and experience unique barriers and facilitators to HIV care engagement. In formative work, we identified culturally specific and modifiable barriers to HIV treatment engagement among transgender women living with HIV (TWH), including prioritizing transition-related healthcare over HIV treatment, avoiding HIV care settings due to gender-related and HIV stigma, concerns about potential drug interactions with hormones, and inadequate social support. Grounded in the investigators' Models of Gender Affirmation and Health Care Empowerment, we developed theHealthy Divasintervention to optimize engagement in HIV care among TWH at risk for treatment failure and consequential morbidity, mortality, and onward transmission of HIV.Methods and Analysis:We conducted a 2-arm randomized controlled trial (RCT) of the intervention's efficacy in Los Angeles and San Francisco to improve engagement in care among TWH (N= 278). The primary outcome was virologic control indicated by undetectable HIV-1 level (undetectability = &lt; 20 copies/mL), at baseline and follow-up assessment for 12 months at 3-month intervals.Ethics and Dissemination:This study was approved by University of California, San Francisco Institutional Review Board (15-17910) and Western Institutional Review Board (20181370). Participants provided informed consent before enrolment in the study. We are committed to collaboration with National Institutes of Health officials, other researchers, and health and social services communities for rapid dissemination of data and sharing of materials. The results will be published in peer-reviewed academic journals and scientific presentations. We will make our results available to researchers interested in transgender health to avoid unintentional duplication of research, as well as to others in health and social services communities, including HIV clinics, LGBT community-based organizations, and AIDS service organizations.Clinical Trial Registration:Clinicaltrials.gov, identifier NCT03081559.
UKURAN PERUSAHAAN MEMODERASI DETERMINAN AUDIT DELAY
Authors: Maharsa Agustinus Guntur , Darminto Dwi Prastowo , Merawati Endang Etty 
Published: October 2021

Abstract

The time span between the issuance date of the audit report and the closing date of the financial year is called the audit delay. This study aims to examine the effect of good corporate governance represented by the board of commissioners and audit committee, leverage, auditor switching, profitability, on audit delay with company size as a moderating variable. This research was conducted at trade service and investment companies listed on the Indonesia Stock Exchange in 2015-2019. The number of samples was selected by purposive sampling method is 268 samples from 56 companies for five years. The type of data used is secondary data in the form of financial statements of trade service and investment companies. The data analysis technique used is Moderated Regression Analysis. The results showed that the board of commissioners and audit committee, leverage, profitability have an effect on audit delay, while auditor switching has no effect on audit delay. Company size moderates the effect of leverage and profitability on audit delay, but company size is unable to moderate the effect of auditor switching on audit delay.
Keywords: good corporate governance, board of commissioners, audit committee, leverage, auditor switching, profitability, company size, audit delay
Statistical Estimates of the Decline of the Russian Fertility: Regional Specifcs
Authors: Shubat O. M. 
Published: October 2021

The study focuses on analyzing regional features of the decline in the birth rate in Russia in 2016–2019. Taking into account regional specifcs is crucial when perfecting the implemented measures for improving the general demographic situation in the Russian Federation.The information base of the study contained time series of the total fertility rate in selected Russian regions. The author used methods of descriptive statistics and assessed convergent trends based on the sigma-, beta- and gamma-convergence methods. Spatial eﬀects in regional diﬀerentiation of fertility were assessed based on Moran's I.As a result of the analysis, the following features were established. Firstly, in recent years in Russia, there has been a high degree of diﬀerentiation in the recorded declining birth rates. Secondly, the processes of falling fertility in the regions have specifc characteristics, the absence of typical trajectories in those subjects where it fell most or least of all. Thirdly, in Russia, there are no pronounced territo rial localizations of the processes of fertility decline. And fourthly, based on a comparison of the birth rate dynamics in Russian regions, no convergent trends have been identifed, i. e., there is no convergence of territorial entities in terms of the birth rate.According to the author, the demographic policy of recent years has not yet responded positively either in terms of birth rate growth or leveling of regional diﬀerences. The results obtained indicate that unifed approaches are unsuited to solving the demographic problems of Russian territories, and there is a need for demographic policy measures that take into account regional variability and are aimed at smoothing regional disproportions. Consequently, it is necessary to conduct regular statistical and demographic studies of the specificity of regional situations using methods of convergence and spatial autocorrelation analysis, rarely used in demography
Experience of pharmacological cardioversion with refralon in persistent atrial fibrillation and flutter according to the data of the cardiology department of Orenburg regional clinical hospital
Authors: Kozlova L. K. , Sokolova N. V. , Sivkova A. V. , Kamyshanova A. E. , Abramova O. Y. , Kuchma G. B. , Turmukhambetova B. T. , Nikonova E. N. 
Published: October 2021

Aim. To assess the effectiveness and safety of refralon based cardioversion on the experience of the cardiology department of Orenburg Regional Clinical Hospital.Methods. The archival medical histories of 14 patients with persistent atrial fibrillation (AF) and 2 patients with persistent atrial flutter (AFL) (overall 16 patients), who underwent an attempt to restore sinus rhythm with refralon, were analyzed. The mean age of the patients was 51.7±10.4 years. The mean duration of AF/AFL since its last detection was 8.0±6.5 weeks (from 8 days to 8 months). Fifteen patients had hypertension, 3 of them had coronary artery disease (CAD), and 1 patient had CAD with type 2 diabetes mellitus. One of the patients had lone AF. Before cardioversion, all patients underwent the following examination: clinical and biochemical blood tests, clinical urine tests, electrocardiography (ECG), echocardiography (Echo), transesophageal Echo, Holter ECG, the determination of the level of thyroid-stimulating hormone, thyroxine, electrolytes, including potassium and magnesium.Results. According to Echo, initially, the transverse size of the left atrium in patients was 4.3±0.3 cm. Its increase was noted in 68.7% of patients (from 4.3 to 5.0 cm). Restoration of sinus rhythm after the first step of refralon administration at a dose of 10 μg/kg was achieved in 8 patients, after the second step of administration (total dose 20 μg/kg) - in 5 patients and after the third step (total dose 30 μg/kg) - in 2 patients. In 1 patient, restoration of sinus rhythm was not achieved after the administration of the third bolus. Out of 15 patients with restored sinus rhythm, AF recurrence occurred in three. In one of the patients with successful cardioversion, the sinus rhythm was restored the next day. The duration of the last episode of AF and the size of the left atrium did not significantly affect the effectiveness of cardioversion and amounted to 62±54 days and 4.3±0.35 cm, respectively, in patients with successful cardioversion, and with a recurrence of AF - 34.3±28 days and 4.2±0.35 cm (p=0.2; р=0.6). The efficacy of cardioversion with refralon was 71.4% in patients with AF, and 100% in patients with AFL. No adverse events of refralon were found in patients.Conclusion. At the time of discharge, sinus rhythm was recorded in 12 out of 16 patients (75%). The ineffectiveness of cardioversion with refralon was noted only in patients with AF; in all patients with AFL the sinus rhythm was restored.
Efficacy and safety of anticoagulant therapy in real clinical practice in patients with persistent atrial fibrillation after interventional treatment
Authors: Eshmatov O. R. , Batalov R. E. , Dragunova M. A. , Archakov E. A. , Popov S. V. 
Published: October 2021

Aim. To study the efficacy and safety of anticoagulant therapy in patients with persistent atrial fibrillation (AF) after interventional treatment during 36 months of follow-up.Material and methods. The study included 135 patients (78 men and 58 women) in the age from 31 to 80 years (mean age 61.0 [55; 66]) with persistent AF who underwent catheter treatment. All patients were treated in the arrhythmia department of the Research Institute of Cardiology (Tomsk National Research Medical Center from 01.01.2017 to 31.12.2017.Results. In patients with persistent AF, the effectiveness of catheter treatment was 60% after 12 months of follow-up (81 patients had no documented AF during this period) and 63.7 % (n=86) - after 24 and 36 months. No fatal outcomes, myocardial infarction, or ischemic stroke were observed within 12 months after catheter treatment in patients with an effective procedure. During 36 months of follow-up, the incidence of ischemic stroke on the background of receiving anticoagulant therapy and effective catheter treatment of persistent AF was significantly lower than in patients with unsuccessful ablation (1.16% and 10%, respectively), even though not all patients from the first group received prescribed medication.Conclusion. Successful radiofrequency procedure/cryo-ablation of AF persistent form significantly reduced the risk of ischemic stroke from 10% to 1.16% and almost eliminated the likelihood of other thromboembolic complications, while the invasive strategy did not increase the risk of large and small bleeding in this group of patients.
Atrial fibrillation and stroke risk factors in patients with cardiac implantable electronic devices
Authors: Rakhimova I. R. , Khaibullin T. N. , Kovalchuk V. V. , Abdrakhmanov A. S. 
Published: October 2021

Purpose. Determination the proportion and burden of new-onset atrial fibrillation (AF) in patients with cardiac implantable electronic devices (CIED) and without prior AF and assessing the incidence of risk factors for stroke in patients with AF.Methods. The medical history of 111 patients with CIED with remote monitoring function were analyzed. AF diagnosed by the device was interpreted by an arrhythmologist and cases of significant AF were selected. The group of patients with and without AF was compared for several factors. To clarify the influence of risk factors on the duration of AF, all AF cases were divided into 3 categories depending on the AF burden per day. The first group included patients with an AF burden per day of 0.1% or less (n=10, (45.5%)), the second - from 0.3% to 12.2% (n=7, (31.8%)), and the third group - with 100% (n=5, (22.7%)). Patients with a burden of 0.2%, 12.3-99.9% were absent.Results. Newly diagnosed AF was registered in 19.8% of cases. The risk of stroke among these patients was high - 2 [1; 3] points on the CHA2 DS2 -VASc for men, and 3 [2,75; 3,75] points for women. Hypertension of 2 and 3 degrees was recorded in all patients in the group with an AF burden of 100% per day. That significantly differed from the other 2 groups (p=0.043). In the group with an AF burden of 100%, the levels of NT-proBNP, D-dimer, and creatinine were significantly higher than in the other groups (p=0.037, p=0.031 and p=0.036, respectively). When analyzing the dependence of creatinine level on the presence of AF, the area under the ROC-curve was 0.653 with 95% confidence interval 0.528-0.779 (p=0.017). The proportion of right ventricular pacing in patients with ICD was higher in the group of patients with AF.Conclusion. AF occurs in 1/5 of patients with CIED. All patients with AF were potential candidates for anticoagulation due to their high risk of stroke. The daily burden of AF is positively correlated with the presence and degree of hypertension, as well as with markers of renal dysfunction, chronic heart failure, and thrombosis. Elevated creatinine levels are a predictor of AF.
Experience with various occluder types for endovascular hemodynamic isolation of the left atrium appendage in patients with non-valvular atrial fibrillation
Authors: Pevzner D. V. , Merkulov E. V. , Arutyunyan G. K. , Komarov A. L. , Shakhmatova O. O. , Ushanova A. M. , Merkulova I. A. , Davtyan K. V. , Chazova I. E. 
Published: October 2021

The aimof our study was to evaluate implantation efficacy and safety across various occluder types and to identify factors determining device selection.Methods. This single-site prospective observational study included patients above the age of 40 years with non-valvular atrial fibrillation (AF) and high thromboembolic risk, undergoing endovascular isolation of the left atrium appendage (LAA) with Watchman or Amplatzer Cardiac Plug/Amulet devices. Occluders were implanted to patients without either had contraindications to anticoagulant therapy (ACT) or refused ACT. We evaluated technical aspects of device implantation, short- and long-term outcomes of the intervention over 3 years of follow-up.Results. 90 patients were enrolled in the study (62 into the Watchman arm and 28 into the Amplatzer arm). Interventions were technically successful in 89 cases. In 1 patient (1/90, 1.1%) technical success was not achieved due to device migration (Amplatzer Amulet). The incidence of early (occurring within˂ 24 hours) implantation complications was 0% in the Watchman arm, and 3.6% in the Amplatzer arm (1/28) (р=0.135) (device migration). The cumulative incidence of all in-hospital complications was 11.3% and 14.3%, respectively (р=0.734). No significant differences between arms were found in the incidence of device thrombosis within 90 days post-implantation (3.3% in the Watchman’s arm and 8.3% in the Amplatzer arm, р=0.316). During the observation period, there were no significant differences in comparison groups in the incidence of net clinical efficacy endpoint events (р=0.58). The bleeding rate was 17.7% and 14.3%, respectively, р=0.769. No factors influencing the choice of the device could be identified reliably; however, there was a trend towards Watchman preference for appendage anatomic variants such as broccoli and cactus. Amplatzer was preferred in patients with contraindications to ACT.Conclusion.Implantation of Watchman and Amplatzer Amulet occluders is equally effective and safe in preventing thromboembolism in patients with AF not receiving ACT for various reasons. The individual choice of a device may be influenced by appendage anatomy and indications to occluder implantation.
Peragaan Penggunaan Meja Instrumen Multifungsi Pemantau Kesehatan Balita di Posyandu
Authors: Purwanti Bernadeta S. Rahayu , Nuralam Nuralam , Mawardi Latif 
Published: October 2021

Covid-19 memberlakukan 5M, yaitu Memakai masker, Mencuci tangan pakai sabun dan air mengalir, Menjaga jarak, Menjauhi kerumunan, serta Membatasi mobilisasi dan interaksi. Dua dari 5M, yaitu menjaga jarak dan menjauhi kerumunan sangat ketat diterapkan sampai sekarang, walaupun hampir seluruh masyarakat sudah divaksinasi. Demikian juga para kader Posyandu Rambutan di Blok Tempe, RT6 RW II, Desa Citeureup yang secara rutin memantau kesehatan balita. Pemantauan dilakukan lebih cepat dengan pengukuran berat badan, pengukuran tinggi badan, dan suhu menggunakan tiga alat ukur yang berbeda. Ketiga layanan pengukuran tersebut dapat menimbulkan antrian, akibat alat-alat ukur masih konvensional. Oleh karena itu muncul ide, membuat meja multifungsi dengan tiga macam pengukuran secara otomatis. Selain sebagai alat pengukur suhu, secara bersamaan juga untuk menimbang badan dan mengukur tinggi balita. Selanjutnya, secara spesifik hanya membahas uji alat ukur yaitu memastikan fungsi dari sensor loadcell, LiDAR, dan infrared pada meja instrument. Cara kerja meja instrumen; balita ditidurkan di atas kasur busa. Kaki balita harus menyentuh kayu pembatas di ujung laci meja agar tinggi badan balita dapat terukur. Kasur busa berada di dalam laci meja yang didesain sedemikian rupa sehingga balita aman. Salah satu sisi meja terdapat dinding yang telah dipasang sensor ultrasonik sebagai pengukur tinggi, dan berat badan balita juga dapat diukur pada saat bersamaan. Hal tersebut dikarenakan, bagian bawah penyangga laci dipasang sensor loadcell sebagai penimbang. Laci bagian bawah untuk layanan balita ≤ 12 bulan atau belum bisa berdiri di atasnya. Sedangkan balita yang usia 12-59 bulan, pemeriksaannya dilakukan di bagian sisi dinding kompartemen. Hasil pengukuran pada alat dapat ditampilkan di Liquid Crystal Display (LCD) data hasil deteksi tiga sensor. Kader dapat melakukan pengukuran suhu tubuh balita (oC), berat badan (kg), dan tinggi badan (cm) menggunakan meja instrument dengan mengikuti petunjuk pengunaannya. Booklet yang memuat petunjuk penggunaan sesuai tahap pengukuran, dipasang di sisi depan dinding meja instrument. Kata Kunci: Balita, Berat, Pengukur, Sensor, Tinggi.
Cold sintering for Li1.5Al0.5Ge1.5(PO4)3 using LiNO3-LiOH as a transient solvent
Authors: Takashima Kenji , Iwazaki Yoshiki , Randall Clive A. 
Published: October 2021

Abstract
The cold sintering process (CSP) is an innovative technique to densify ceramic powders at ultralow temperatures by applying uniaxial pressure and using a transient solvent. However, obtaining dense Li1.5Al0.5Ge1.5(PO4)3 (LAGP) ceramics, which have high ionic conductivity, by CSP has been a challenging subject, because incongruent dissolution from the powder to a solvent can happen during CSP, and that deteriorates the grain boundary. In this study, LiNO3-LiOH salt is used as the transient solvent to suppress the incongruent dissolution. LAGP ceramics densified by the CSP at 220 °C and 400 MPa for 5 h have no damage at the grain boundary. As the result, the total ionic conductivity reaches 1.9 × 10−5 S cm−1, which is the highest value ever reported among LAGP ceramics prepared by CSP only using inorganic materials.
Multi-level 2-bit/cell operation utilizing Hf-based metal/oxide/nitride/oxide/silicon nonvolatile memory with HfO2 and HfON tunneling layer
Authors: Pyo Jooyoung , Ihara Akio , Zhang Wendi , Nishino Shuma , Ohmi Shun-ichiro 
Published: October 2021

Abstract
This paper investigated the multi-level 2-bit/cell operation utilizing a Hf-based metal/oxide/nitride/oxide/silicon (MONOS) nonvolatile memory (NVM) device with a HfO2 and HfON tunneling layer (TL). The 2-bit/cell operation is realized by utilizing the localized charge injection method. It was found that drain-current–gate-voltage (I
D–V
G) characteristics of the programmed states were affected by asymmetry localized in a trapped location along the channel direction. Moreover, the amount of localized trapped charge is strongly affected by drain-source voltage (V
DS) in the case of HfON TL. HfON TL shows distinguishable separated all programmed states compared to HfO2 TL. Finally, it was found that all programmed states of HfO2 and HfON TL show similar characteristics according to the channel length and width (L/W) of 2–10/15–90 μm.
Effect of dehydration time and air tightness on pore distribution of potassium and metakaolin-based geopolymer
Authors: Yang Yaru , Le Thi-Chau-Duyen , Kudo Isamu , Do Thi-Mai-Dung , Niihara Koichi , Suematsu Hisayuki 
Published: October 2021

Abstract
As a catalyst support in the nuclear waste containers in the Fukushima Daiichi Nuclear Power Station, geopolymer is required to show high strength, high porosity and durability. The aim of this study is to evaluate the mechanical properties and pore size distribution of hardened samples based on two test variables, which include early-age dehydration time and air tightness. The early-age dehydration time ranges from 1–4 d, and air tightness is implemented using the two methods of total sealing and air contact. However, the average pore size was around 2.0 × 102
μm, the Vickers hardness was around 90 MPa, and the relative weight change on the 14th day was within 10% for all the samples that were not affected by the curing time and air tightness. It can be inferred that the pores of the sample may have been formed within a day and may not be affected by the curing time.
Genetically modified animals for use in biopharmacology: from research to production
Authors: Deykin Alexey V. , Shcheblykina Olesya V. , Povetka Elena E. , Golubinskaya Polina A. , Pokrovskiy Vladimir M. , Korokina Liliya V. , Vanchenko Olesya A. , Kuzubova Elena V. , Trunov Konstantin S. , Vasyutkin Viktor V. , Radchenko Alexandra I. , Danilenko Anton P. , Stepenko Julia V. , Kochkarova Indira S. , Belyaeva Veronika S. , Yakushev Vladimir I. 
Published: October 2021

Introduction: In this review, the analysis of technologies for obtaining biologically active proteins from various sources is carried out, and the comparative analysis of technologies for creating producers of biologically active proteins is presented. Special attention is paid to genetically modified animals as bioreactors for the pharmaceutical industry of a new type. The necessity of improving the technology of development transgenic rabbit producers and creating a platform solution for the production of biological products is substantiated.
The advantages of using TrB for the production of recombinant proteins: The main advantages of using TrB are the low cost of obtaining valuable complex therapeutic human proteins in readily accessible fluids, their greater safety relative to proteins isolated directly from human blood, and the greater safety of the activity of the native protein.
The advantages of the mammary gland as a system for the expression of recombinant proteins: The mammary gland is the organ of choice for the expression of valuable recombinant proteins because milk is easy to collect in large volumes.
Methods for obtaining transgenic animals: The modern understanding of the regulation of gene expression and the discovery of new tools for gene editing can increase the efficiency of creating bioreactors for animals and help to obtain high concentrations of the target protein.
The advantages of using rabbits as bioreactors producing recombinant proteins in milk: The rabbit is a relatively small animal with a short duration of gestation, puberty and optimal size, capable of producing up to 5 liters of milk per year per female, receiving up to 300 grams of the target protein.
Violência contra as mulheres nos games:
Authors: Galdino Renata Jéssica , Silva Tarcisio Torres 
Published: October 2021

Este trabalho discute a violência contra as mulheres nos games. Evidencia ser este um campo de tensão, pois ao mesmo tempo em que cresce a participação feminina em competições e em iniciativas do setor, crescem também as manifestações contrárias à maior presença feminina num ambiente até pouco tempo atrás predominantemente masculino. Através do levantamento de dados quantitativos, análise de conteúdo e discussão de casos como o da ativista Anita Sarkeesian e da hashtag gamergate, observamos que a violência que se manifesta nos games é reflexo de uma cultura machista presente na indústria e em parte da comunidade gamer. Por outro lado, a antipatia de uma parcela do público masculino tem contribuído para a melhor organização das mulheres de iniciativas para buscar espaço no setor e fortalecer sua presença.
Palavras-chave: mulher, games, misoginia.