bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotection of Extracellular Vesicles From Human Adipose Stem Cells Intranasally Administered 24 Hours After Stroke In Rats
Authors: Rohden Francieli , Teixeira Luciele Varaschini , Bernardi Luis Pedro , Ferreira Pâmela Cristina Lukasewicz , Colombo Mariana , Teixeira Geciele Rodrigues , Oliveira Fernanda dos Santos de , Lima Elizabeth Obino Cirne , Guma Fátima Rodrigues , Souza Diogo Onofre 
Published: March 2021

Abstract
Ischemic stroke is a prominent cause of death and disability, demanding for innovative and reachable therapeutic strategies. Thus, approaches presenting optimal period for therapeutic intervention and new routes of treatments administration as promising tools for stroke treatment. In this study, we evaluated the potential neuroprotective properties of nasally administration of human adipose tissue stem cells (hAT-MSC)-derived extracellular vesicles (EVs), obtained from healthy individuals submitted to liposuction. A single intranasal EVs (200 µg/Kg) administration performed 24 h after a focal permanent ischemic stroke in rats. Was observed a higher tropism of EVs by peri-infarct zone, surrounding the infarct core. Interestingly, in the same brain region, was observed a significant decrease in the volume of the infarct, improvement the blood-brain barrier and re-stabilization of vascularization. In addition, EVs recover the impairment on long-term motor and behavioral performance induced by ischemic stroke. Surprisingly, one single intranasal EVs administration reestablished: i) front paws symmetry; ii), short- and long-term memory; iii) anxiety-like behavior. In keeping with this, our work highlights hAT-MSC-derived EVs as a promising therapeutic strategy in stroke.
Silver Oxide Nanostructure: a Study on Physical Properties at Different Chemical Interaction Time
Authors: salim evan T. , Awayiz Muntadher Talib 
Published: March 2021

Abstract
Chemical bath deposition method was employed for the deposition of smooth quantum size Ag2O nanostructure thin film on glass substrate at three different chemical interaction times. The structural properties shows the demonstration of Ag2O cubic structure at (002) diffraction plane. Optical properties reflect the dependence of energy gab on the interaction time with moderate band gab energy of about 2.25eV.Other physical properties such as SEM, AFM, was also investigated.
An Artificial Neural Network approach for parametric study on Welding Defect Classification
Authors: HO mei po , NGAI Wing-kit , CHAN Tai-wing , WAI Hon-wah 
Published: March 2021

Abstract
In this paper, a welding defect prediction model has been developed and investigated through training an Artificial Neural Network (ANN) based model. The input data were three welding process measurements (Welding current, Travel speed, and Protective gas Flow). The output data were non-destructive test results of respective weldments on four defect types (Underfill, Lack of penetration, Incomplete fusion, and Porosity) to ensure the consistency of the welding following the designed parameters, all data were obtained from 289 specimens produced by an automated MIG welding manufacturing system. The 2-stages model with 13 inputs, hidden layers with 80–100 neurons, 4 outputs. the outputs were used to evaluate the classification accuracy in the confusion matrix for the prediction of weld quality. A further 73 specimens were used to test the accuracy of the trained ANN model. The model achieved 85% accuracy.
Investigation Structure and Properties of Wire From The Alloy of Al-rem System Obtained With The Application of Casting in The Electromagnetic Mold, Combined Rolling-Extruding and Drawing
Authors: Sidelnikov Sergey Borisovich , Voroshilov Denis Sergeevich , Motkov Mikhail Mikhaylovich , Timofeev Viktor Nikolaevich , Konstantinov Igor Lazarevich , Dovzhenko Nikolay Nikolaevich , Lopatina Ekaterina Sergeevna , Bespalov Vadim Mikhaylovich , Sokolov Ruslan Evgenyevich , Mansurov Yulbarskhon Nabievich , Voroshilova Marina Vladimirovna 
Published: March 2021

Abstract
The paper presents the results of studies of the structure and properties of a wire with a diameter of 0.5 mm from an alloy of the Al-REM system with a rare-earth metal content of 7-9%. Wire obtained as a result of the implementation of the technology of its manufacture using the methods of casting into an electromagnetic mold (EMM), continuous extruding and drawing.The rheological properties of the metal of continuously cast round billets from the experimental alloy obtained using an electromagnetic mold are determined. The modeling and analytical assessment of the possibility of carrying out the process of combined rolling-extruding (CRE) of such billets in a closed box-type roll groove of a continuous extruding unit are carried out. The features of metal shaping have been studied. The temperature-speed and technological parameters was found at which the CRE process can be carried out in a stable mode of operation. Data have been obtained for the forces acting on the die and rolls and the moments on the rolls during rolling-extruding.The results of experimental studies of the process of obtaining longish deformed semi-finished products from an experimental alloy on the laboratory unit CRE-200 and the pilot plant unit CRE-400 are presented. The structure of the metal has been studied; data on the ultimate tensile strength, yield strength, relative elongation, and electrical resistivity of hot-extruded rods and wires in cold-worked and annealed states have been obtained.It was found that the proposed processing modes make it possible to obtain by the method of combined rolling-extruding rods with a diameter of 9 mm in industrial conditions from longish billets with a diameter of 18 mm, cast by means of EMM. Wire in a cold-worked and annealed state with a diameter of 0.5 obtained by drawing from the rods with a diameter of 9 mm from an experimental alloy of the Al-REM system containing 7-9 rare earth metals with the required physical and mechanical properties.
Clinical effect analysis of laminectomy alone and laminectomy with instrumentation in the treatment of TOLF: a multicentre retrospective study
Authors: Wang Zhe Wei , Wang Zheng , Zhou Yan Hong , Sun Jia Yuan , Ding Wen Yuan , Yang Dalong 
Published: March 2021

Abstract
Background To explore the clinical effect of laminectomy alone and laminectomy with instrumentation in the treatment of TOLF.Methods A retrospective study was conducted on the clinical data of 142 patients with TOLF and laminectomy in the Spine surgery of the XXX Medical University from January 2003 to January 2018. According to whether the laminectomy was combined with instrumentation, the patients were divided into two groups: group A (laminectomy alone LA, n = 77) and group B (laminectomy with instrumentation LI, n = 65). Comparison possible influencing factors of demographic variables and operation-related variables between the two groups. In this study, the clinical effects of laminectomy alone and laminectomy with instrumentation in the treatment of TOLF were discussed. Thus to explore the clinical effect of LA and LI in the treatment of TOLF.Results In terms of demographics, there was a statistically significant difference in BMI between group A and Group B (P < 0.05). The differences in Age, Sex, Smoking, Drinking, Heart disease, Hypertension and Diabetes were not statistically significant (P༞0.05). In terms of preoperative symptoms, there was significant difference in Gait disturbance, Pain in LE,Urination disorder between group A and group B (P < 0.05), but there was no significant difference in other variables between the two groups (P > 0.05). In terms of operation-related variables, there was significant difference in Preoperative duration of symptoms, Intramedullary signal change on MRI, Dural ossification, Residual rate of cross-sectional spinal canal area on CT, Shape on the sgittal MRI, Operation time, Pre-mJOA, Post-mJOA at 1 year,Leakage of cerebrospinal fluid between group A and group B (P < 0.05), but there was no significant difference in other variables between the two groups (P > 0.05). The preoperative average JOA score of group A was 6.37, and that of group B was 5.19. In group A, the average JOA score at 6 months, 1 year and 2 years after surgery was 7.87, 8.23 and 8.26, respectively, and the average JOA score improvement rate was 32.79%, 38.32% and 38.53%, respectively. In group B, the average JOA score at 6 months, 1 year and 2 years after surgery was 7.74, 8.15 and 8.29, respectively, and the average JOA score improvement rate was 39.15%, 46.86% and 47.12%, respectively.Conclusions Currently, there was no consensus on whether instrumentation is needed after laminectomy for TOLF. We found that for patients with long duration of Gait disturbance, Urination disorder, Preoperative duration of symptoms, Intramedullary signal change on MRI, Dural ossification, Residual rate of cross-sectional spinal canal area on CT less than 60%, Shape on the sgittal MRI as Beak and low Pre-mJOA had better clinical effect after LI than that LA, and the incidence of perioperative complications was lower.
MiR-26a-1 Promotes DNA Damage Repair by Inhibiting Sirt1 and KDM5A in Human Liver Cancer Stem Cells
Authors: Wang Liyan , Li Xiaonan , Qin Rushi , Lu Yanan , Song shuting , Chen Yingjie , Xie Sijie , Jiang Xiaoxue , Lu Dongdong 
Published: March 2021

Abstract
Background: Although miR-26a-1 was down-regulated expressin in several cancers, the role of miR-26a-1in malignancies has yet to be systematically elucidated. Methods: RT-PCR, Western blotting and tumorigenesis test in vitro and in vivo were performed to analyze the signaling pathway. Results: miR-26a-1 inhibits the NAD(+)-dependent deacetylase Sirt1 expression by targeting the 3' non-coding region of Sirt1 which enhances the acetylation modification of H4 on the 16th lysine of histone and the expression of protein arginine methyltransferase PRMT6. Therefore, miR-26a-1 promotes arginine methylation modification of POLB (R137) and histone. On the other hand, miR-26a-1 inhibits the expression of KDM5A by targeting its 3' non-coding region, which enhances the methylation modification of histone H3 ysine 4. Moreover, miR-26a-1 enhances the expression of histone methyltransferase SETD2 dependent on H3K4me3 and further increases the trimethylation modification of the histone H3 lysine 36 . Significantly, miR-26a-1 promotes the formation of DNA damage repair complex (Rad51-PARP1-ATR-ATM-hMSH6-XRCC-POLB-SKP2) via H3K36me3. In particular, it was found that miR-26a-1 inhibited the function of long non-coding RNA HULC and promoted the formation of DNA damage repair complex. Furthermore, miR-26a-1 promotes the DNA damage repair ability by promoting the DNA damage repair complex to bind to the DNA damage site, thereby inhibiting the DNA damage of liver cancer stem cells. In particular, miR-26a-1 enhanced the binding of H3F3A to Skp2, CUL1, and F-box at the DNA damage site and enhanced the protein ubiquitination modification of H3F3A, which promoted Histone H3 replaces H3F3A by degrading H3F3A, realizing the renewal of histones after DNA damage repair. It was further found that miR-26a-1 inhibited the formation and instability of DNA microsatellites by promoting DNA damage repair, thereby affecting the expression of several cyclins and protein kinases in liver cancer stem cells, such as, inhibiting CDK2 and CyclinE , CDK4, CyclinD1, CDK6, CDK8, CyclinM2, CDK15, pRB, PCNA, MAP3K2, PGK1 and promoting RB, P18, P21/WAF1/Cip1, and thus inhibited the growth of liver cancer stem cells. Strikingly, the rescued-test further confirmed that excessive Sirt1 and KDM5A abrogated the oncogenic function of miR-26a-1. Conclusions: miR26a-1 may acts as the potential biomarker and therapeutic target for liver cancer.
Malnutrition is an Independent Risk Factor for Low Health-related Quality of Life Among Centenarians
Authors: Yang Shanshan , Wang Shengshu , Liu Wei , Han Ke , Jia Wangping , Liu Guangdong , Tai Penggang , Kou Fuyin , Liu Miao , He Yao 
Published: March 2021

Abstract
Background: To explore the association and understand gender disparities between nutritional status and quality of life among centenarians.Methods: It was a full-sample survey of centenarians conducted in Hainan that included a total of 1,002 eligible centenarians whose age had been verified. The Mini Nutritional Assessment – Short Form (MNA-SF) questionnaire and the EuroQol five dimensions visual analog scale (EQ-5D-VAS) were used to measure participants’ nutritional status and quality of life, respectively. Findings: In the 1002 centenarians (822 women and 180 men), 797 (79·5%) reported multimorbidity. The adjusted standardized β estimate for the association between the MNA-SF and EQ-5D scores was 0·508 in the complete sample. With reference to the normal nutrition group, the standardized β estimate of the association between EQ-5D score and nutritional status were −0·179 and −0·583 for the at risk of malnutrition and malnutrition groups, respectively (both P <0·001). Nutritional status significantly affected the five dimensions of quality of life, particularly mobility and self-care. Compared with the normal nutrition group, the malnutrition group had greater odds of low mobility (Odds ratio (OR)=23·15; 95% CI: 9·81–54·64) and low self-care (OR=24·58; 95% CI: 12·62–47·89). Among males, nutritional status was significantly associated with the usual activities and anxiety/depression dimensions after adjustment. Female participants had results similar to the general population. Interpretation: Malnutrition and being at risk of malnutrition is prevalent among centenarians. Maintaining normal nutritional status is an important protective factor and should receive more attention to improve centenarians’ quality of life.
Microsurgical Resection of Foramen Magnum Meningioma: Multi-institutional Retrospective Case Series and Proposed Surgical Risk Scoring System.
Authors: Fatima Nida , Shin John H. , Curry William T. , Chang Steven D. , Meola Antonio 
Published: March 2021

Abstract
Purpose

Foramen magnum meningiomas (FMMs) are a major surgical challenge, due to relevant surgical morbidity and mortality. The paper aims to review the clinical (symptomatic improvement, complication rate, length of hospital stay) and radiological outcome (completeness of resection) of microsurgical resection of FMMs, and to identify predictors of complications.
Methods

A multi-institutional retrospective review of prospectively maintained database of FMMs included 51 patients (74.5% females) with a median tumor volume of 8.18 cm3 (range, 1.77–57.9 cm3) and median follow-up of 36 months (range, 0.30–180.0 months). Tumors were resected though suboccipital approach (58.8%) or transcondylar approach (39.3%).
Results

Gross-total resection (GTR) was achieved in 80.4%, while local tumor control in 98% of cases. Clinical symptoms improved in 34 patients (66.7%) and worsened in 5 (9.8%). The median length of hospital stay was 5 days. Mortality was null. Postoperative complications developed in 15 patients (29.4%), with cerebrospinal fluid leak (7.8%) and lower cranial nerves deficits (7.8%) as the most frequent. Craniospinal location (p = 0.03), location anterior to the dentate ligament (DL) (p = 0.02), involvement of vertebral artery (VA) (p = 0.03) were significantly associated with complication rate. These three elements allow calculating the Foramen Magnum Meningioma Risk Score (FRMMRS), to estimate the risk of post-operative complications.
Conclusion

Microsurgical resection allows for high GTR rate and local tumor control rate, despite complications in one third of the patients. The FMMRS allows classifying FMMs and estimating the risk of post-operative complications.
A Siamese Network with Adaptive Gated Feature Fusion for Individual Knee OA Features Grades Prediction
Authors: Wang Kang , Niu Xin , Dou Yong , Xie Dongxing , Yang Tuo 
Published: March 2021

Abstract
Grading individual knee osteoarthritis (OA) features is a fine-grained knee OA severity assessment. Existing methods ignore following problems: (1) more accurately located knee joints benefit subsequent grades prediction; (2) they do not consider knee joints’ symmetry and semantic information, which help to improve grades prediction performance. To this end, we propose a SE-ResNext50-32x4d-based Siamese network with adaptive gated feature fusion method to simultaneously assess eight tasks. In our method, two cascaded small convolution neural networks are designed to locate more accurate knee joints. Detected knee joints are further cropped and split into left and right patches via their symmetry, which are fed into SE-ResNext50-32x4d-based Siamese network with shared weights, extracting more detailed knee features. The adaptive gated feature fusion method is used to capture richer semantic information for better feature representation here. Meanwhile, knee OA/non-knee OA classification task is added, which helps extract richer features. We specially introduce a new evaluation metric (top±1 accuracy) aiming to measure model performance with ambiguous data labels. Our model is evaluated on two public datasets: OAI and MOST datasets, achieving the state-of-the-art results comparing to competing approaches. It has the potential to be a tool to assist clinical decision making.
Modeling and Estimation of Cutting Forces in Ball Helical Milling Process
Authors: Wang Haiyan , Tao Kexin , Jin Tian 
Published: March 2021

Abstract
Milling forces play an important role in the milling process and are generally calculated by the mechanistic or numerical methods, reliable model of cutting force is very important for the simulation of milling process, which has big scientific significance to further improve machining quality. Ball helical milling technology is used to make holes based on the cutting principle of helical milling using ball end cutter, due to the influence of spherical surface machining characteristic, the modeling of cutting force in ball helical milling is difficult. Therefore, the main purpose of this paper is to first establish an analytical cutting force model in the ball helical milling process. Considering cutting characteristics in the axial feed, the kinematics of ball helical milling is first presented, then the chip thickness distribution in different directions along the cutting edges are predicted. Furthermore, based on the characteristics of helical milling technology and geometry shape of ball end mill and the classical mechanical cutting force model, through the study on the ball-end milling mechanics, a new relatively accurate theoretical cutting force model is established. At the same time, cutting force coefficients are identified through instantaneous force method according to the Ti-alloy experimental research result. Finally, higher simulation precision of cutting force model in ball helical milling process is received.
Effects of Medicaid Expansion on Poverty Disparities in Health Insurance Coverage
Authors: Lin Yilu , Monnette Alisha , Shi Lizheng 
Published: March 2021

Abstract
Background: More than 30 States have either expanded Medicaid or considering expansion. The coverage gains from this policy is well documented, however, the impacts of its increasing coverage on poverty disparity are unclear at national level.Method: American Community Survey (2012-2018) was used to examine the effects of Medicaid expansion (ME) on poverty disparity in insurance coverage for nonelderly adults in the United States. Differences-in-differences-in-differences design was used to analyze the trends in uninsured rates (UR) by different poverty levels: <138%, 138–400% and >400% federal poverty level (FPL).Results: Compared with UR in 2012, UR in 2018 decreased by 10.75%, 6.42%, and 1.11% for <138%, 138-400%, and >400% FPL. From 2012-2018, >400% FPL group continuously had the lowest UR and <138% FPL group had the highest UR. Compared with ≥ 138% FPL groups, there was a 2.54% reduction in uninsured risk after ME among <138% FPL group in ME states versus control states. After eliminating the impact of the ACA market exchange premium subsidy, 3.18% decrease was estimated. Conclusion: Poverty disparity in UR improved with ME. However, <138% FPL population are still at a higher risk for being uninsured.
Immediate Effects of Using Insoles With Various Wedges on Plantar Pressure Measurements and Comfort Level During Marching
Authors: Shirvani Hossein , Ghasemi Mohamad Hossein , Shamsoddini Alireza , Barati Kourosh 
Published: March 2021

Abstract
Background: Orthotic devices like insoles are widely used to improve performance. This study investigated whether immediate effects of using insoles with various wedges influence on plantar pressure measurements and comfort level during marching.Methods: Twenty five able-bodied males participated in this study voluntarily. Repeated measures analysis of variance test with a Bonferroni correction (P<0.0014) was used to compare dependent variables among nine insole wedge conditions.Results: The result of present study showed that the comfort level was non-significantly higher in the anterior and medial wedges compared to the posterior-lateral and anterior-lateral wedges during marching (P>0.0014). The peak of plantar pressure and impulse in the first to third metatarsal regions decreased in the anterior, medial and anterior-medial wedges compared to the lateral and posterior-lateral wedges (P<0.0014). In addition, a significant negative relation between the comfort level and plantar pressure measurements was observed in the second and third metatarsals and midfoot regions during marching (P<0.05).Conclusion: It seems that using anterior, medial and anterior-medial wedge for insole may have some advantage through increasing comfort sense and decreasing the risk of stress fracture injuries in the second and third metatarsal regions. These findings should be considered during designation of shoes or insoles for military environments.