bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macroinvertebrate interactions stimulate decomposition in WWTP effluent-impacted aquatic ecosystems
Authors: van der Meer Tom V. , van der Lee Gea H. , Verdonschot Ralf C. M. , Verdonschot Piet F. M. 
Published: August 2021

AbstractAquatic ecosystems worldwide are impacted by an influx of nutrients and sludge particles from wastewater treatment plant (WWTP) effluents, leading to a degradation of benthic habitats and a loss of associated macroinvertebrate taxa. Hence, in habitats impacted by WWTPs, only a few tolerant macroinvertebrate taxa remain. These tolerant detritivore macroinvertebrate taxa play an important role in the degradation of organic matter, and biotic interactions between these taxa may either enhance or reduce the rate of sludge degradation. Therefore, the aim of the present study was to examine if the interaction between asellids and tubificids, both highly abundant in systems impacted by WWTP effluent, enhances the degradation of sludge. To this end, growth and reproduction of both taxa, sludge degradation and nutrient concentrations in the overlying water were measured in a 28-day laboratory experiment, subjecting WWTP sludge to 4 treatments: a control without macroinvertebrates, a tubificid, an asellid, and an asellid + tubificid treatment. Sludge degradation, phosphate concentration in the overlying water and asellid reproduction were enhanced when asellids and tubificids were jointly present, whereas tubificid growth and reproduction were hampered in comparison to the tubificid treatment. Hence, our results suggest that the biotic interactions between these tolerant detritivores stimulate sludge degradation, and thus possibly mitigating the negative impacts of WWTP-derived sludge particles on the benthic environment.
Second Tier Testing to Reduce the Number of Non-actionable Secondary Findings and False-Positive Referrals in Newborn Screening for Severe Combined Immunodeficiency
Authors: Blom Maartje , Pico-Knijnenburg Ingrid , Imholz Sandra , Vissers Lotte , Schulze Janika , Werner Jeannette , Bredius Robbert , van der Burg Mirjam 
Published: August 2021

AbstractPurposeNewborn screening (NBS) for severe combined immunodeficiency (SCID) is based on the detection of T-cell receptor excision circles (TRECs). TRECs are a sensitive biomarker for T-cell lymphopenia, but not specific for SCID. This creates a palette of secondary findings associated with low T-cells that require follow-up and treatment or are non-actionable. The high rate of (non-actionable) secondary findings and false-positive referrals raises questions about the harm-benefit-ratio of SCID screening, as referrals are associated with high emotional impact and anxiety for parents.MethodsAn alternative quantitative TREC PCR with different primers was performed on NBS cards of referred newborns (N = 56) and epigenetic immune cell counting was used as for relative quantification of CD3 + T-cells (N = 59). Retrospective data was used to determine the reduction in referrals with a lower TREC cutoff value or an adjusted screening algorithm.ResultsWhen analyzed with a second PCR with different primers, 45% of the referrals (25/56) had TREC levels above cutoff, including four false-positive cases in which two SNPs were identified. With epigenetic qPCR, 41% (24/59) of the referrals were within the range of the relative CD3 + T-cell counts of the healthy controls. Lowering the TREC cutoff value or adjusting the screening algorithm led to lower referral rates but did not prevent all false-positive referrals.ConclusionsSecond tier tests and adjustments of cutoff values or screening algorithms all have the potential to reduce the number of non-actionable secondary findings in NBS for SCID, although second tier tests are more effective in preventing false-positive referrals.
Reference data among general population and known-groups validity among hypertensive population of the EQ-5D-5L in Vietnam
Authors: Mai Vu Quynh , Giang Kim Bao , Minh Hoang Van , Lindholm Lars , Sun Sun , Sahlen Klas Göran 
Published: August 2021

Abstract
Purpose
This study aims to provide EQ-5D-5L population norms among the general population in Vietnam and to test EQ-5D-5L’ construction validity among people living with hypertension there.

Methods
Descriptive statistics of the five dimensions and five levels, EQ-VAS and EQ-5D-5L indexes were categorised into gender and age groups for the EQ-5D-5L population norms. Known-groups testing was set for lower EQ-5D-5L outcomes among people who were aware of their hypertensive status, females, people with more comorbidities, less education, older ages, and higher body mass indexes. Level of confident interval was 95%.

Results
The mean EQ-VAS and EQ-5D-5L indexes were 81.10 (SD: 13.35) and 0.94 (SD: 0.09) among the general population. The EQ-5D-5L outcomes were better among younger people, males, people with more education, employees, and single people. Respondents reported fewer problems with self-care and usual activities and tend to have problems at higher levels across older ages. The known-group testing showed statistically significant results. The mean EQ-VAS and EQ-5D-5L indexes of people in the diagnosed hypertensive group (71.48 and 0.94, respectively) were statistically significantly smaller than they were in the non-hypertensive and undiagnosed hypertensive group (76.65 and 0.97; 76.95 and 0.96 accordingly). Statistically significant associations of lower EQ-5D-5L indexes and EQ-VAS were found among people diagnosed for hypertension, people suffering from an incremental comorbidity, and obese people.

Conclusion
This study has provided EQ-5D-5L population norms for the general population and evidence for known-groups validity of the EQ-5D-5L instrument among hypertensive people in Vietnam.
Report on outcomes of valve-in-valve transcatheter aortic valve implantation and redo surgical aortic valve replacement in the Netherlands
Authors: van Steenbergen G. J. , van Straten B. , Lam K. Y. , van Veghel D. , Dekker L. , Tonino P. A. 
Published: August 2021

Abstract
Objective
We sought to investigate real-world outcomes of patients with degenerated biological aortic valve prostheses who had undergone valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) or reoperative surgical aortic valve replacement (redo-SAVR) in the Netherlands.

Methods
Patients who had undergone ViV-TAVI or redo-SAVR for a degenerated biological aortic valve prosthesis in the Netherlands between January 2014 and December 2018 were eligible for this retrospective study. Patients with a prior homograft, active endocarditis or mechanical aortic valve prosthesis were excluded. Patients were matched using the propensity score. The primary endpoint was a composite of 30-day all-cause mortality and in-hospital postoperative stroke. Secondary endpoints were all-cause mortality at different time points, in-hospital postoperative stroke, pacemaker implantation and redo procedures within one year. Baseline characteristics and outcome data were collected from the Netherlands Heart Registration.

Results
From 16 cardiac centres, 653 patients were included in the study (374 ViV-TAVI and 279 redo-SAVR). European System for Cardiac Operative Risk Evaluation I (EuroSCORE I) was higher in ViV-TAVI patients (19.4, interquartile range (IQR) 13.3–27.9 vs 13.8, IQR 8.3–21.9, p < 0.01). After propensity score matching, 165 patients were matched with acceptable covariate balance. In the matched cohorts, the primary endpoint was not significantly different for ViV-TAVI and redo-SAVR patients (odds ratio 1.30, 95% confidence interval 0.57–3.02). Procedural, 30-day and 1‑year all-cause mortality rates, incidence of in-hospital postoperative stroke, pacemaker implantation and redo procedures within one year were also similar between cohorts.

Conclusion
Patients with degenerated aortic bioprostheses treated with ViV-TAVI or redo-SAVR have similar mortality and morbidity.
Publication Inaccuracies Listed in General Surgery Residency Training Program Applications
Authors: Yeh Daniel Dante , Reynolds John M. , Pust Gerd Daniel , Sleeman Danny , Meizoso Jonathan P. , Menzel Christopher , Horkan Davis , Lineberry Matthew , Yudkowsky Rachel , Park Yoon Soo 
Published: August 2021

BACKGROUND:
Professionalism is a core competency that is difficult to assess. We examined the incidence of publication inaccuracies in Electronic Residency Application Service applications to our training program as potential indicators of unprofessional behavior.

STUDY DESIGN:
We reviewed all 2019–2020 National Resident Matching Program applicants being considered for interview. Applicant demographic characteristics recorded included standardized examination scores, gender, medical school, and medical school ranking (2019 US News & World Report). Publication verification by a medical librarian was performed for peer-reviewed journal articles/abstracts, peer-reviewed book chapters, and peer-reviewed online publications. Inaccuracies were classified as “nonserious” (eg incorrect author order without author rank promotion) or “serious” (eg miscategorization, non-peer-reviewed journal, incorrect author order with author rank promotion, nonauthorship of cited existing publication, and unverifiable publication). Multivariate logistic regression analysis was performed for demographic characteristics to identify predictors of overall inaccuracy and serious inaccuracy.

RESULTS:
Of 319 applicants, 48 (15%) had a total of 98 inaccuracies; after removing nonserious inaccuracies, 37 (12%) with serious inaccuracies remained. Seven publications were reported in predatory open access journals. In the regression model, none of the variables (US vs non-US medical school, gender, or medical school ranking) were significantly associated with overall inaccuracy or serious inaccuracy.

CONCLUSIONS:
One in 8 applicants (12%) interviewing at a general surgery residency program were found to have a serious inaccuracy in publication reporting on their Electronic Residency Application Service application. These inaccuracies might represent inattention to detail or professionalism transgressions.
Decreased leucocyte telomere length in male patients with chronic bipolar disorder: lack of effect of long-term lithium treatment
Authors: Ferensztajn-Rochowiak Ewa , Kurczewska Ewa , Rubiś Błażej , Lulkiewicz Michalina , Hołysz Hanna , Rybakowski Filip , Rybakowski Janusz K. 
Published: August 2021

AbstractObjectives:Bipolar disorder (BD) may be connected with accelerated aging, the marker of this can be shorter telomere length (TL). Some data suggest that lithium may exert a protective effect against telomere shortening. The study aimed to compare the TL between patients with BD and control subjects. The effect of long-term lithium treatment was also assessed.Methods:The study group comprised 41 patients with BD, including 29 patients treated longitudinally with lithium (mean 16.5 years) and 20 healthy people. TL was assessed by the quantitative polymerase chain reaction (qPCR).Results:In the control group, the TL was significantly longer in males than in females. Male bipolar patients had significantly shorter TL compared with the control male group. In bipolar patients, there was no correlation between TL and duration of treatment. The TL was negatively correlated with age in male bipolar patients.Conclusions:The study did not confirm the lithium effect on TL in bipolar patients. TL showed gender differences, being shorter in BD males, compared to control males, and longer in healthy males, compared to control females.
Selection of reference genes for quantitative real-time PCR normalization in the coffee white stem borer, Xylotrechus quadripes Chevrolat (Coleoptera: Cerambycidae)
Authors: Meng Qianqian , Shu Benshui , Sun Shiwei , Wang Ying , Yang Mei , Zhu Enhang , Liu Aiqin , Gao Shengfeng , Gou Yafeng , Wang Zheng 
Published: August 2021

AbstractThe coffee white stem borer, Xylotrechus quadripes Chevrolat (Coleoptera: Cerambycidae), is a major destructive pest of Coffea arabica L. (Gentianales: Rubiaceae), widely planted in many Asian countries, including China. Quantitative real-time polymerase chain reaction (qRT-PCR) is a common method for quantitative analysis of gene transcription levels. To obtain accurate and reliable qRT-PCR results, it is necessary to select suitable reference genes to different experimental conditions for normalizing the target gene expression. However, the stability of the expression of reference genes in X. quadripes has rarely been studied. In this study, the expression stability of nine candidate reference genes were investigated under biotic and abiotic conditions for use in qRT-PCR's normalization. By integrating the results of four algorithms of NormFinder, BestKeeper, geNorm, and RefFinder, the optimal reference gene combinations in different experimental conditions were performed as follows: RPL10a and EIF3D were the optimal reference genes for developmental stage samples, EIF4E, RPL10a, and RPS27a for tissue samples, V-ATP and EF1α for the sex samples, EIF3D and V-ATP for temperature treatment, RPS27a and RPL10a for insecticide stress, and RPL10a, RPS27a, and EF1α for all the samples. This study will help to obtain the stable internal reference genes under biotic and abiotic conditions and lay the foundation for in-depth functional research of target genes or genomics on olfactory molecular mechanisms, temperature adaptability, and insecticide resistance in X. quadripes.
Making an Arab-Muslim Elite in Paris: The Pan-Maghrib Student Movement of the 1930s
Authors: Watanabe Shoko 
Published: August 2021

AbstractThis paper aims to clarify the scope and limitations of the ideals of Pan-Maghrib nationalism as developed by the Association of North African Muslim Students in France (AEMNAF) in the 1930s. The AEMNAF members’ inclination toward sciences and technology and their emphasis on conserving their mother culture made them consider Arabism and Islam their most important identity markers. Moreover, the AEMNAF created a sense of solidarity among Maghribi students in France and extended its social influence by cooperating with French and Mashriqi opinion leaders in Europe. However, the AEMNAF's narrow definition of Muslim-ness and its elitist nature led to the exclusion of Maghribis with French citizenship from the organization. The dualistic view of technology and culture in Maghribi nationalist thought also contributed to prioritizing Francophones over Arabophones, Muslims over non-Muslims, men over women, and students in the sciences over those in humanities.
Counterparty Risk in Over-the-Counter Markets
Authors: Frei Christoph , Capponi Agostino , Brunetti Celso 
Published: August 2021

AbstractWe study trading and risk management decisions of banks in over-the-counter markets, accounting for 2 types of risk: payoff risk from loans and counterparty risk from trading activities. Our model provides empirically supported predictions on the structure of the interbank credit default swap (CDS) market: i) banks with high default probabilities either buy or sell CDS contracts; ii) because of the counterparty risk friction, payoff risk is only partially shared; and iii) safe banks act as intermediaries and help diversify counterparty risk. Banks manage their default probabilities to become creditworthy counterparties, but they do so in a socially inefficient way.
Visiting the complex bibliography ofThe Zoology of the Voyage of H.M.S. Erebus and Terror, 1839-1843
Authors: Rosove Michael H. 
Published: August 2021

AbstractDeciphering the bibliographical details ofThe Zoology of the Voyage of H.M.S. Erebus and Terror, 1839-1843has long been problematic owing to production of theZoologyin 24 parts over a 31-year time span (1844−1875), two publication periods (1844−1848, 1874−1875) each with a different publisher, non-consecutive issuance of text pages and plates, non-uniform plate numbering, ambiguities in publication dates and publisher imprints, conflicting bibliographical information in previous reports, and perhaps most of all the extreme rarity of parts still in their original state. The present report, based on what appears to be the most thorough examination of parts and reissues in original state to date, closes numerous knowledge gaps.
GROWTH, FIXED, AND MIXED MINDSETS
Authors: Lou Nigel Mantou , Chaffee Kathryn Everhart , Noels Kimberly A. 
Published: August 2021

AbstractLanguage learners’ mindsets–their beliefs about whether language is a fixed aptitude that is immutable or a malleable capacity that can be developed–are associated with achievement goals, language-use anxiety, reappraisals of challenges, and persistence. This study integrates these mindset-related constructs to identify mindset-system profiles among foreign language learners. A latent profile analysis of 234 university students in foreign language courses revealed three distinct profiles. The fixed (21.8%) and growth (20.5%) profiles showed distinct and contrasting patterns of goals, reappraisals, anxiety, and persistence. However, most learners (57.7%) endorsed a mixed profile. Although mindsets alone did not predict grades, students in the growth profile were consistently most engaged and achieved the highest grades, suggesting that mindsets function as a system, in concert with related factors. This person-centered approach enhances our understanding of the complexity and functions of the mindset system, as well as the motivation of learners with mixed mindsets.
Associations of observed callous–unemotional behaviors in early childhood with conduct problems and substance use over 14 years
Authors: Donohue Meghan Rose , Hoyniak Caroline P. , Tillman Rebecca , Barch Deanna M. , Luby Joan 
Published: August 2021

AbstractCallous–unemotional (CU) behaviors (i.e., low concern and active disregard for others) uniquely predict severe conduct problems and substance use when present by late childhood. Less is known about the predictive utility of CU behaviors displayed in early childhood, when morality is developing and interventions may be more effective. Children aged 4–7 years (N = 246; 47.6% girls) completed an observational task wherein they were encouraged to tear an experimenter's valued photograph, and blind raters coded children's displayed CU behaviors. During the next 14 years, children's conduct problems (i.e., oppositional defiant and conduct symptoms) and age of onset of substance use were assessed. Compared to children displaying fewer CU behaviors, children displaying greater CU behaviors were 7.61 times more likely to meet criteria for a conduct disorder (n = 52) into early adulthood (95% CI, 2.96–19.59; p = <.0001), and their conduct problems were significantly more severe. Greater CU behaviors were associated with earlier onset of substance use (B = −.69, SE = .32, t = −2.14, p = .036). An ecologically valid observed indicator of early CU behavior was associated with substantially heightened risk for conduct problems and earlier onset substance use into adulthood. Early CU behavior is a powerful risk marker identifiable using a simple behavioral task which could be used to target children for early intervention.
Medical Care in a Police Intervention with Conducted Electrical Weapons: Zaragoza (Spain) Fire Department Protocol
Authors: Cester-Martínez Armando , Serrano-Lasaosa Leticia , Borraz-Clares Diego 
Published: August 2021

AbstractIn the last decade, conducted electrical weapons (CEWs) have become a new tool for law enforcement agencies as an alternative to firearms. They provide security in the intervention for both the police and the citizen and try to cause the least possible harm to the subject to immobilize.The health care providers who perform in joint actions with the police in which CEWs are used should be aware of how they work, risk groups, as well as the most frequent clinical effects associated with the application of electrical discharge, and the complications that can be produced according to the area of impact of the electrodes.For this purpose, the current medical literature was reviewed by consulting the main health care sciences database (PubMed) to determine the medical measures to be taken before, during, and after the use of these weapons. Also presented and shared is the Zaragoza (Spain) Fire Department protocol.
Design of cost-efficient Glucose meter
Authors: Rao Sanjana , Mohanty Sattwik , Amarnani Chirag , Fakir Kausar , Dhobale Sandip , Agarkar Trupti 
Published: August 2021

A blood glucose metre is a small, portable device that measures blood glucose levels. To avoid long-term complications from diabetes, careful blood glucose control is required. New blood glucose metres have a small size, a large memory capacity, blood glucose manipulation techniques, and computer-based data processing capabilities.The Glucose Detection System is implemented in tandem with an improved Op-based Potentiostat and an automatic test system. This project's goal is to investigate an improved OP-based Three-Electrode Potentiostat that can be used in an Electrochemical Glucose Biosensor device to achieve comparable measurement accuracy. This Project enables us to make the Glucometer Cost-Efficient, Affordable and Easy to Use. They hold a lot of promise in the field of bio-detection on the go systems for use in health care and biomedicine.
Taste Dysfunction in Children—A Clinical Perspective and Review of Assessment Methods
Authors: van den Brink Mirjam , IJpma Irene , Tissing Wim J E , Havermans Remco C 
Published: August 2021

Abstract
Taste dysfunction has been associated with aging and is therefore thought to be less common in children. However, children can face medical conditions influencing their taste function. Measuring and understanding taste dysfunction in children may foster the development of treatments/interventions mitigating the detrimental effects of taste dysfunction on children’s appetite and quality of life. But measuring loss of taste function requires adequate tools. This review was conducted to 1) provide an overview of etiologies (i.e., disease and iatrogenic) associated with taste dysfunction in a pediatric population; 2) to investigate which tools (psychophysical tests and questionnaires) are available to assess taste function in children; and 3) to identify what tools can be and are actually used in clinical practice. It is concluded that only a minority of available tools to assess taste function in children are readily suitable for a pediatric clinical setting. Considering the profound impact of taste dysfunction in the pediatric setting, developing, and implementing a standard taste test that is sensitive, simple, and practical to use with children is pertinent.