bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN ANTARA INTERAKSI SOSIAL TEMAN SEBAYA DENGAN PENERIMAAN SOSIAL SISWA KELAS XI IPA SMA NEGERI 09 KOTA BENGKULU
Authors: Yuliani Maelan Tri , Syahriman Syahriman 
Published: March 2021

ABSTRAKPenelitian ini bertujuan untuk mengetahui hubungan antara interaksi sosial teman sebaya dengan penerimaan sosial pada siswa kelas XI di SMA Negeri 9 Kota Bengkulu.Penelitian ini menggunakan pendekatan kuantitatif dengan jenis korelasional. Subjek dalam penelitian ini adalah siswa kelas XI dengan jumlah siswa sebanyak 76 orang. Teknik pengambilan sampel dalam penelitian ini ialah dengan menggunakan total sampling. Alat pengumpulan data menggunakan skala interaksi sosial teman sebaya dan skala penerimaan sosial. Uji validitas instrumen menggunakan product moment dari Pearson, sedangkan reliabilitas menggunakan Alpha cronbach dengan nilai koefisien 0,753 pada interaksi sosial teman sebaya dan 0,908 pada penerimaan sosial. Analisis data untuk menguji hipotesis dengan menggunakan teknik korelasi product moment dari Pearson.Hasil penelitian ini menunjukkan bahwa terdapat hubungan yang positif dan signifikan antara interaksi sosial teman sebaya dengan penerimaan sosial pada siswa kelas XI di SMA Negeri 09 Kota Bengkulu. Hal ini ditunjukkan dengan koefisien korelasi (rxy) sebesar 0,91 atau lebih dari 0,05 dan p = 0,000 (p < 0,05) yang berarti hipotesis alternatif (Ha) diterima. Besarnya koefisien korelasi bersifat positif, artinya semakin tinggi tingkat interaksi sosial teman sebaya siswa, semakin tinggi pula tingkat penerimaan sosial, sebaliknya, semakin rendah tingkat interaksi sosial teman sebaya siswa, semakin rendah pula tingkat penerimaan sosial. Kata kunci : interaksi sosial teman sebaya, penerimaan sosial
Ganho ponderal e estado nutricional de mulheres portadoras de diabetes mellitus gestacional
Authors: Neris Vanessa Alves , Silva Tatiana Vanessa Nascimento da , Albuquerque Mellina Neyla de Lima , Augusto Flaviani Diogo Reis , Gomes Andressa Caroline Burgos , Silva Silvia Alves da , Maio Regiane , Burgos Maria Goretti Pessoa de Araújo 
Published: March 2021

Objetivo: Analisar o ganho ponderal e o estado nutricional de gestantes portadoras de diabetes mellitus gestacional. Metodologia: Trata-se de um estudo de caráter descritivo, com corte transversal, realizado entre agosto a dezembro de 2020, em serviço de referência de gestação de alto risco de Pernambuco. Foram estudadas variáveis antropométricas, sociodemográficas, clínicas, obstétricas e de estilo de vida. Para análise estatística foram utilizados os testes Qui-Quadrado de Pearson e Exato de fisher, quando aplicável, com nível de significância de 5%. Resultados: Foram avaliadas 101 gestantes com idade de 30,73 ± 6,29 anos, a maioria (79,2%) com excesso de peso prévio e com elevação durante a gestação (85,1%). O ganho ponderal acima do recomendado foi predominante (45,3%), revelando associação positiva com o estado nutricional atual. A presença de patologias associadas ao DMG foi a única variável obstétrica, que apresentou associação significativa com o estado nutricional prévio, atual e ganho ponderal gestacional, independente do tipo de comorbidades. Conclusão: O ganho ponderal acima do recomendado foi predominante, assim como a frequência de excesso de peso antes e durante a gestação, o que evidencia a importância do acompanhamento nutricional em portadoras de diabetes mellitus gestacional.
MANAJEMEN PRODUKSI PROGRAM MIMBAR AGAMA TVRI RIAU-KEPRI
Authors: Ismandianto Ismandianto , Susilawati Neneng Susi 
Published: March 2021

AbstrakProgram mimbar agama merupakan program pendidikan mengenai keagamaan yang ditayangkan secara live di TVRI Riau, dengan mengangkat tema yang berbeda-beda setiap minggunya sesuai dengan agama masing-masing, yaitu: Islam, Kristen Protestan, Khatolik, Budha dan Hindu yang diisi oleh narasumber yang berbeda. Penelitian dilakukan untuk melihat manajemen produksi program acara dengan menggunakan teori POAC yaitu perencanaan, pengorganisasian, penggerakan, dan pengawasan. Penelitian ini menggunakan metode deskriptif kualitatif. Teknik pengumpulan dilakukan dengan observasi, wawancara dan dokumentasi. Pengambilan narasumber dengan menggunakan pertimbangan tertentu sesuai dengan tujuan penelitian. Informan dalam penelitian ini sebanyak empat orang yaitu produser program, pengarah acara serta pengisi acara. Hasil dari penelitian ini yaitu: Pertama membuat susunan acara program mimbar agama mulai dari perencanaan isi dan biaya. Kedua membuat susunan kerabat kerja yang bertugas dalam pelaksanaan perencanaan produksi program. Ketiga penggerakan produksi program secara live di TVRI Riau yang melibatkan semua kru yang telah ditentukan dan yang terakhir pengawasan terhadap acara tersebut dengan cara evaluasi yang diakukan oleh produser program secara langsung. Kata Kunci: program; manajemen; agama; televisi. AbstractThe religious pulpit program is an educational program on religion that is broadcast live on TVRI Riau, with a different theme each week according to their respective religions, namely: Islam, Protestant Christianity, Catholicism, Buddhism and Hinduism filled with different sources.. The research was conducted to see the production management of the program using POAC theory, namely planning, organizing, mobilizing, and controlling. This study used descriptive qualitative method. Data collection techniques are the result of observation, interviews and documentation. Retrieval of sources by using certain considerations in accordance with the objectives of the study. The informants in this study were four people, namely program producer, program director and performers. The results of this study are: First, make arrangements for the religious pulpit program starting from content planning and cost planning. Second, make the arrangement of work relatives who are in charge of implementing program production planning. The third is the movement ofprogram production live on TVRI Riau involving all predetermined crews and the last one is supervision of the event by means of evaluation carried out by the program producer directly Keywords: program; management; religious; television.
Efficacy of Various Hypoglycemic Agents in the Treatment of Patients With Nonalcoholic Liver Disease With or Without Diabetes： A Network Meta-Analysis
Authors: Lian Jingxuan , Fu Jianfang 
Published: March 2021

ObjectiveTo comprehensively evaluate and compare the therapeutic effects of various hypoglycemic agents in NAFLD patients with or without diabetes.MethodsAll literature from the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Clinical Trials was searched, and the language was limited to English. Two reviewers independently assessed study eligibility, continuous data extraction, and independent assessment of bias risk. Our primary outcomes were alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride levels, while our secondary outcomes were high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels, body weight, BMI, and fasting glucose and glycosylated hemoglobin (HbA1c) levels.ResultsThe review identified 20 eligible trials that met the inclusion criteria. We found that, compared to other drugs, thiazolidinediones, especially pioglitazone, had a greater effect on the levels of ALT (-8.01 (95% CI -14.3 to 2.02)) and AST (-5.0 (95% CI -9.21 to -1,22)) and other biological indicators, but they were also associated with an increased risk of weight gain (3.62 (95% CI 2.25 to 4.99) and increased BMI (0.59 (95% Cl -0.13 to 1.29). GLP1 RAs and metformin also had better therapeutic effects than other drugs as measured by the levels of ALT (liraglutide: -9.36 (95% Cl -18 to -0.34), metformin: -2.84 (95% CI -11.09 to 5.28)) and AST (liraglutide: -5.14 (95% CI -10.69 to 0.37), metformin: -2.39 (95% CI -7.55, 2.49)) and other biological indicators.ConclusionDespite the significant risk of weight gain, thiazolidinediones, especially pioglitazone, are beneficial in normalizing liver and glucose metabolism in NAFLD patients. In clinical practice, we believe that GLP1 RAs such as liraglutide and exenatide or metformin can be used in combination to offset the risk of weight gain associated with thiazolidinediones. However, long-term studies are still needed to verify the efficacy and safety of individual hypoglycemic agents.Systematic Review Registration[PROSPERO], identifier [CRD42020212025].
Self-reference Network-Related Interactions During the Process of Cognitive Impairment in the Early Stages of Alzheimer’s Disease
Authors: Wei Ping-Hsuan , Chen Haifeng , Ye Qing , Zhao Hui , Xu Yun , Bai Feng ,   on behalf of Alzheimer’s Disease Neuroimaging Initiative
Published: March 2021

Background: Normal establishment of cognition occurs after forming a sensation to stimuli from internal or external cues, in which self-reference processing may be partially involved. However, self-reference processing has been less studied in the Alzheimer’s disease (AD) field within the self-reference network (SRN) and has instead been investigated within the default-mode network (DMN). Differences between these networks have been proven in the last decade, while ultra-early diagnoses have increased. Therefore, investigation of the altered pattern of SRN is significantly important, especially in the early stages of AD.Methods: A total of 65 individuals, including 43 with mild cognitive impairment (MCI) and 22 cognitively normal individuals, participated in this study. The SRN, dorsal attention network (DAN), and salience network (SN) were constructed with resting-state functional magnetic resonance imaging (fMRI), and voxel-based analysis of variance (ANOVA) was used to explore significant regions of network interactions. Finally, the correlation between the network interactions and clinical characteristics was analyzed.Results: We discovered four interactions among the three networks, with the SRN showing different distributions in the left and right hemispheres from the DAN and SN and modulated interactions between them. Group differences in the interactions that were impaired in MCI patients indicated that the degree of damage was most severe in the SRN, least severe in the SN, and intermediate in the DAN. The two SRN-related interactions showed positive effects on the executive and memory performances of MCI patients with no overlap with the clinical assessments performed in this study.Conclusion: This study is the first and primary evidence of SRN interactions related to MCI patients’ functional performance. The influence of the SRN in the ultra-early stages of AD is nonnegligible. There are still many unknowns regarding the contribution of the SRN in AD progression, and we strongly recommend future research in this area.
Perampanel Improves Cortical Myoclonus and Disability in Progressive Myoclonic Epilepsies: A Case Series and a Systematic Review of the Literature
Authors: Assenza Giovanni , Nocerino Cristofaro , Tombini Mario , Di Gennaro Giancarlo , D'Aniello Alfredo , Verrotti Alberto , Marrelli Alfonso , Ricci Lorenzo , Lanzone Jacopo , Di Lazzaro Vincenzo , Bilo Leonilda , Coppola Antonietta 
Published: March 2021

Introduction: Progressive myoclonic epilepsies (PMEs) are a heterogenous group of genetic diseases presenting with epilepsy, cognitive impairment, and severe action myoclonus, which can severely affect daily life activities and independent walking ability. Perampanel is a recent commercially available antiseizure medication with high efficacy against generalized seizures. Some reports supported the role of perampanel in ameliorating action myoclonus in PMEs. Here, we aimed to describe a case series and provide a systematic literature review on perampanel effects on PMEs.Methods: We report the perampanel effectiveness on myoclonus, daily life activities, and seizures on an original Italian multicenter case series of 11 individuals with PMEs. Then, using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, we performed a systematic review on perampanel effect on myoclonus and disability in PMEs. We searched PubMed, Scopus, and Google Scholar articles on perampanel and PMEs up to June 2020. No prospective trials were found. We reviewed 11 case series manuscripts reporting 104 cases of different PMEs.Results: Here, we are reporting the effectiveness of perampanel in five individuals affected by Unverricht–Lundborg disease, three by Lafora disease, two by sialidosis, and one by an undetermined PME. Nine out of 11 individuals improved their disability related to the action myoclonus (two with Lafora disease did not). Among the 104 persons with PMEs collected by the systematic review, we found that more than half of the patients receiving perampanel exhibited an amelioration of action myoclonus and, consequently, of their independence in daily life activities. The Unverricht–Lundborg disease seemed to show the best clinical response to perampanel, in comparison with the other more severe PMEs. A significant seizure reduction was achieved by almost all persons with active epilepsy. Only 11% of PME patients dropped out due to inefficacy.Conclusions: Perampanel demonstrated a beneficial effect with regard to action myoclonus, disability, and seizures and was well-tolerated in people with PMEs, independently from their genetic diagnosis. Given the limited scientific evidence, broader prospective trials should be encouraged.
Protective Effects of Deferoxamine on Vestibulotoxicity in Gentamicin-Induced Bilateral Vestibulopathy Rat Model
Authors: Kim Hyo-Jung , Lee Jin-Ok , Kim Ji-Soo 
Published: March 2021

Introduction: Administration of aminoglycoside (AG) antibiotics is one of the most common causes of ototoxicity. This study aimed to determine the protective effects of deferoxamine, an iron-chelating agent, on vestibulotoxicity using an intratympanic gentamicin injection (ITGM)-induced bilateral vestibulopathy rat model.Methods: Fifteen Sprague-Dawley rats were randomly assigned to the ITGM only (n = 5), the ITGM combined with intramuscular deferoxamine (DFO) injection (ITGM+DFO, n = 5), or the intratympanic normal saline (control, n = 5) group. The rats in the ITGM+DFO group received intramuscular injection of 150 mg/kg of deferoxamine at 30, 90, and 150 min after the ITGM. The vestibular function was evaluated using the rotarod and open field test every 3 days after the injection until Day 16 when the rats were subjected to histological changes.Results: The rats in the ITGM only group began to show significantly impaired vestibular function 2 days after ITGM into both ears. In contrast, the vestibular function was maintained in the control and ITGM+DFO groups without a difference throughout the experiments. The rats in the ITGM only group showed a near-complete loss of the type I and II hair cells and a collapse of the sensory epithelium in both the saccule and utricle. In contrast, the rats in the ITGM+DFO and control groups showed a relatively well-preserved sensory epithelium including the hair cells, cilia, and otolith layer.Conclusion: This study provides experimental evidence for preventive effects of iron-chelating agents on AG-induced vestibulotoxicity. Simultaneous administration of iron-chelating agents may be considered when using ototoxic agents, especially in those considered to be vulnerable to toxic damage of the inner ear.
PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model
Authors: Li Xilei , Guo Qulian , Ye Zhi , Wang E. , Zou Wangyuan , Sun Zhihua , He Zhenghua , Zhong Tao , Weng Yingqi , Pan Yundan 
Published: March 2021

BackgroundPrevious studies have proved that peripheral nerve injury is involved in the pathogenesis of neuropathic pain (NP). The peripheral nerve injury primes spinal M1 microglia phenotype and produces pro-inflammatory cytokines, which are responsible for neurotoxic and neuronal hyper-excitable outcomes. Spinal peroxisome proliferator-activated receptor gamma (PPAR γ) has been shown to play an anti-inflammatory role in the development of NP. However, the role of PPAR γ in attenuating the pathological pathway of spinal microgliosis is still unknown.MethodsSprague-Dawley rats (male, aged 8–10 weeks) were randomly divided into three groups, i.e., a control group, a NP group, and a NP + lentivirus encoding PPAR γ (LV-PPAR γ) group. The sciatic chronic constriction injury (CCI) model was used to induce NP in rats. Pain behavior was assessed by monitoring the rat hind-paw withdrawal threshold to mechanical stimuli and withdrawal latency to radiant heat. The LV-PPAR γ was intrathecally infused 1 day before CCI. Western blot analysis and real-time qPCR were used to detect the microglia phenotypic molecules and CX3CR1 expression in the spinal cord. In vitro, BV-2 microglia cells were transfected with LV-PPAR γ and incubated with lipopolysaccharides (LPS), and the levels of M1 microglia phenotypic molecules and CX3CR1 in BV-2 microglia cells were assessed by western blot analysis, real-time qPCR, and enzyme-linked immunosorbent assay.ResultsPreoperative intrathecal infusion of LV-PPAR γ attenuated pain in rats 7 days post-CCI. The M1-microglia marker, CX3CR1, and pro-inflammatory signaling factors were increased in the spinal cord of CCI rats, while the preoperative intrathecal infusion of LV-PPAR γ attenuated these changes and increased the expression of IL-10. In vitro, the overexpression of PPAR γ in BV-2 cells reduced LPS-induced M1 microglia polarization and the levels of CX3CR1 and pro-inflammatory cytokines.ConclusionIntrathecal infusion of LV-PPAR γ exerts a protective effect on the development of NP induced by CCI in rats. The overexpression of PPAR γ may produce both analgesic and anti-inflammatory effects due to inhibition of the M1 phenotype and CX3CR1 signaling pathway in spinal microglia.
Identification and Development of Subtypes With Poor Prognosis in Pan-Gynecological Cancer Based on Gene Expression in the Glycolysis-Cholesterol Synthesis Axis
Authors: Wang Guangwei , Liu Xiaofei , Wang Dandan , Sun Meige , Yang Qing 
Published: March 2021

Objective: Metabolic reprogramming is an important biomarker of cancer. Metabolic adaptation driven by oncogenes allows tumor cells to survive and grow in a complex tumor microenvironment. The heterogeneity of tumor metabolism is related to survival time, somatic cell-driven gene mutations, and tumor subtypes. Using the heterogeneity of different metabolic pathways for the classification of gynecological pan-cancer is of great significance for clinical decision-making and prognosis prediction.Methods: RNA sequencing data for patients with ovarian, cervical, and endometrial cancer were downloaded from The Cancer Genome Atlas database. Genes related to glycolysis and cholesterol were extracted and clustered coherently by using ConsensusClusterPlus. The mutations and copy number variations in different subtypes were compared, and the immune scores of the samples were evaluated. The limma R package was used to identify differentially expressed genes between subtypes, and the WebGestaltR package (V0.4.2) was used to conduct Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology functional enrichment analyses. A risk score model was constructed based on multivariate Cox analysis. Prognostic classification efficiency was analyzed by using timeROC, and internal and external cohorts were used to verify the robustness of the model.Results: Based on the expression of 11 glycolysis-related genes and seven cholesterol-related genes, 1,204 samples were divided into four metabolic subtypes (quiescent, glycolysis, cholesterol, and mixed). Immune infiltration scores showed significant differences among the four subtypes. Survival analysis showed that the prognosis of the cholesterol subtype was better than that of the quiescent subtype. A nine-gene signature was constructed based on differentially expressed genes between the cholesterol and quiescent subtypes, and it was validated by using an independent cohort of the International Cancer Genome Consortium. Compared with existing models, our nine-gene signature had good prediction performance.Conclusion: The metabolic classification of gynecological pan-cancer based on metabolic reprogramming may provide an important basis for clinicians to choose treatment options, predict treatment resistance, and predict patients' clinical outcomes.
Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training
Authors: Lionett Sofie , Kiel Ida Almenning , Røsbjørgen Ragnhild , Lydersen Stian , Larsen Steen , Moholdt Trine 
Published: March 2021

Background: Polycystic ovary syndrome (PCOS) and metabolic inflexibility are linked to insulin resistance, and women with PCOS appear to be metabolic inflexible in the rested, insulin-stimulated state. Exercise training is a primary lifestyle intervention in PCOS. Exercise training improves whole-body fat oxidation during submaximal exercise in healthy women, yet little is known about the effect on this outcome in women with PCOS.Methods: We measured whole-body fat oxidation rates during sub maximal exercise before and after 16 weeks of high-intensity interval training (HIT) in women with PCOS randomly allocated to either: low- or high-volume HIT (n = 41; low-volume HIT, 10 × 1 min work bouts at maximal, sustainable intensity and high-volume HIT, 4 × 4 min work bouts at 90–95% of maximal heart rate) or non-exercise control (n = 23), and in women without PCOS (Non-PCOS) allocated to low- or high volume HIT (n = 15). HIT was undertaken three times weekly. In a subset of women with and without PCOS, we measured mitochondrial respiration in abdominal and gluteal subcutaneous adipose tissue using high-resolution respirometry, as well as fat cell sizes in these tissues.Results: At baseline, women with PCOS had lower whole-body fat oxidation and mitochondrial respiration rates in abdominal adipose tissue compared to Non-PCOS. Peak oxygen uptake (mL/min/kg) increased in women with PCOS (~4%, p = 0.006) and Non-PCOS (~6%, p = 0.003) after 16 weeks of HIT. Whole-body fat oxidation only improved in Non-PCOS after HIT. No changes were observed in mitochondrial respiration and cell size in abdominal and gluteal adipose tissue after HIT in either group of women.Conclusion: We observed exercise-induced improvements in whole-body fat oxidation during submaximal exercise in Non-PCOS, but not in women with PCOS, after 16 weeks of HIT, suggesting metabolic inflexibility in women with PCOS.Clinical Trial Registration:www.clinicaltrials.gov, identifier NCT02419482 and NCT02943291.