bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of nutrition intervention strategies in the primary prevention of overweight and obesity in school settings: a protocol for a systematic review and network meta-analysis
Authors: Nury Edris , Morze Jakub , Grummich Kathrin , Rücker Gerta , Hoffmann Georg , Angele Claudia M. , Steinacker Jürgen M. , Conrad Johanna , Schmid Daniela , Meerpohl Jörg J. , Schwingshackl Lukas 
Published: April 2021

Abstract
Background
Overweight and obesity in children and adolescents are major public health challenges affecting quality of life and representing important risk factors in the development of non-communicable diseases. School environments provide great possibilities for the primary prevention of overweight and obesity and different school-based nutrition interventions are available. However, existing research on school-based nutrition interventions has important limitations and no network meta-analysis (NMA) has been performed yet to compare all available interventions. Therefore, the present research project aims to investigate the impact of different nutrition interventions in the school setting by comparing and ranking them using NMA methodology.

Methods/design
A systematic literature search will be performed in 11 electronic databases (PubMed, the Cochrane Library, Web of Science, ERIC, PsycINFO, CAB Abstracts, Campbell Library, BiblioMap EPPI, Australian Education Index, Joanna Briggs Institute Evidence-Based Practice Database and Practice-based Evidence in Nutrition Database). Parallel or cluster randomized controlled trials (RCTs) meeting the following criteria will be included: (1) generally healthy school students aged 4–18 years, (2) school-based intervention with ≥ 1 nutrition component, and (3) assessed anthropometric (overweight/obesity risk, body weight change, weight Z-score, [standardized] body mass index, body fat, waist circumference) and/or diet-quality measures (daily intake of fruits and vegetables, fat, and sugar-sweetened beverages). Random effects pairwise and NMA will be performed for these outcomes and surface under the cumulative ranking curve (SUCRA) estimated (P-score). Where possible, component NMA (CNMA) will be used additionally. Subgroup analyses are carried out for intervention duration, gender, age of school students, socioeconomic status, and geographical location, and sensitivity analyses by excluding high risk of bias RCTs.

Discussion
This systematic review and NMA will be the first to both directly and indirectly compare and rank different school-based nutrition interventions for the primary prevention of overweight and obesity in childhood and adolescence. Our analyses will provide important insights about the effects of the different interventions and show which are the most promising. The results of our study can help inform the design of new studies and will be of value to anyone interested in developing successful, evidence-based nutrition interventions in school settings.

Systematic review registration
PROSPERO: CRD42020220451.
Interventions to prevent obesity in Latinx children globally: protocol for a systematic review and meta-analysis
Authors: Bleiweiss-Sande Rachel , Jiménez-Cruz Arturo , Bacardí-Gascón Montserrat , Skelton Kara , Benjamin-Neelon Sara E. 
Published: April 2021

Abstract
Background
Rates of childhood obesity have accelerated rapidly over the past decade in low- and middle-income countries and in Latin America in particular. At the same time, Latinx children in high-income countries have been disproportionately affected by obesity. Public health and medical experts have called for greater focus on multi-sector approaches to obesity prevention, including policy, systems, and environmental strategies, but current evidence for effective intervention strategies among Latinx children is lacking. Several systematic reviews have investigated obesity prevention interventions in Latinx children in the United States and in Latin America, including our own review, but these are now a decade old. Thus, an updated review of existing interventions is needed. To address this gap, we will conduct a systematic review and summary of interventions for obesity prevention among Latinx children published over the past 10 years. The objective of this paper is to outline the protocol for conducting the systematic review and possible meta-analysis.

Methods
We will conduct a literature search using PubMed, ERIC, PsycINFO, Scopus, Scientific Electronic Library Online, and Google Scholar databases for studies of interventions to prevent obesity in Latinx children ages birth to 18 years of age. To meet our definition of an intervention, we will include study designs that evaluate the either the efficacy or effectiveness of obesity prevention interventions, including randomized controlled trials, quasi-experimental studies, and non-randomized interventions with a control or comparison group. We will exclude interventions that aimed to treat rather than prevent overweight or obesity. Interventions may take place in any country or setting. The primary outcome of interest will be child overweight or obesity, measured as adiposity, body mass, or similar anthropometric measures. We will assess risk of bias of included studies using the Cochrane risk of bias tool for randomized and non-randomized studies, as appropriate. We may conduct meta-analyses if studies with comparable exposure and outcome variables are available.

Discussion
This protocol paper establishes a methodology for a future systemic review of obesity prevention interventions in Latinx children. A systematic review of this topic will provide an important update to the literature regarding interventions to prevent obesity in Latinx child populations globally over the past decade. Review results will be relevant to stakeholders across multiple sectors engaged in childhood obesity prevention among Latinx children.

Systematic review registration
PROSPERO CRD42020161339
Exploring the link among food loss, waste and food security: what the research should focus on?
Authors: Santeramo Fabio G. 
Published: April 2021

AbstractFood loss and food waste are highly debated topics and likely to stay in the research agendas for the next decades. Their relevance is not only important for developing economies, but also for developed economies, especially due to the impact that loss and waste have on the status of food security. In the present editorial, I comment on how research agendas should be shaped in order to focus on emerging issues, and put emphasis on the topics closely connected to the emerging literature on the circular economy.
The role of crowdsourcing and social media in crisis mapping: a case study of a wildfire reaching Croatian City of Split
Authors: Tavra Marina , Racetin Ivan , Peroš Josip 
Published: April 2021

AbstractAs climate change continues, wildfire outbreaks are becoming more frequent and more difficult to control. In mid-July 2017, a forest fire spread from the forests to the city of Split in Croatia. This unpredictable spread nearly caused emergency systems to collapse. Fortunately, a major tragedy was avoided due to the composure of the responsible services and the help of citizens. Citizens helped to extinguish the fire and provided a large amount of disaster-related information on various social media platforms in a timely manner. In this paper, we addressed the problem of identifying useful Volunteered Geographic Information (VGI) and georeferenced social media crowdsourcing data to improve situational awareness during the forest fire in the city of Split. In addition, social media data were combined with other external data sources (e.g., Sentinel-2 satellite imagery) and authoritative data to establish geographic relationships between wildfire phenomena and social media messages. This article highlights the importance of using georeferenced social media data and provides a different perspective for disaster management by filling gaps in authoritative data. Analyses from the presented reconstruction of events from multiple sources impact a better understanding of these types of events, knowledge sharing, and insights into crowdsourcing processes that can be incorporated into disaster management.
Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth
Authors: Villagomez Sofia , Dubal Dena B. , Hawkins Jessica , Wang Dan , Wojcicki Janet M. 
Published: April 2021

Abstract
Background
Klotho is an anti-aging protein mainly expressed in the kidneys with a smaller amount expressed in adipose tissue. Klotho effects include roles in reducing oxidative stress, insulin signaling, adipogenesis and glucose metabolism. Few studies have investigated the role of dietary factors such as sugar sweetened beverages (SSBs) on serum α-klotho levels in young children.

Methods
Data was collected from 60 low-income Latina pregnant women and their infants in San Francisco from birth until 2 years of life and examined for associations between dietary factors and child secreted α-klotho protein levels at 2 years.

Results
Mean α-klotho levels were 1782.96 ± 874.56 pg/mL at 2 years of age. Any consumption of SSBs was independently associated with increased α-klotho levels (Beta = 682.79, 95%CI 67.50, 1298.09; p = 0.03). Household income ranging from $25,000 to $50,000 was also correlated to higher levels of α-klotho in children compared with lower income levels (<$25,000) (Beta = 1613.35, 95%CI 527.37, 2699.33; p = 0.005).

Conclusions
The positive association between SSB intake and α-klotho levels at 2 years may reflect higher phosphate levels consistent with SSB intake. Higher socioeconomic status may be a proxy for reduced stress exposure in children, also associated with higher α-klotho levels. Future studies should evaluate the early impact of exposures to SSBs, stress and accelerated aging in children.
Seeking asylum in Scandinavia: a comparative analysis of recent restrictive policy responses towards unaccompanied afghan minors in Denmark, Sweden and Norway
Authors: Garvik Marianne , Valenta Marko 
Published: April 2021

AbstractThis article investigates recently imposed restrictions in the asylum regimes in Denmark, Sweden and Norway. The purpose of the paper is twofold. First, we aim to identify general changes in asylum policies and asylum legislation. Second, we discuss and compare the policy tools, practices and legislation that have undermined the rights of unaccompanied Afghan minors. We also observe new tools of internal and external deterrence and restrictive asylum policies, combined with tighter border controls. In the case of adult asylum seekers from Afghanistan, high rejection rates and deportations were used for years as an important tool of deterrence. However, these tools were seldom used against unaccompanied Afghan minors before the large influx of asylum seekers in 2015. Since 2015, increased use of rejections, combined with temporary protections, have emerged as the major tools for restriction. We identify similarities and differences in the policy restrictions targeting unaccompanied minors between the countries. Although we identify some recent diverging trends in Scandinavian asylum policies regarding unaccompanied minors from Afghanistan, the general trend of policy restrictions still prevails in all three countries.
A case report of achondrogenesis type II (Langer-Saldino achondrogenesis)
Authors: Maheshwari Saurabh , Ingole Dilip , Chatterjee Samar , Rajesh Uddandam , Anand Varun 
Published: April 2021

Abstract
Background
Achondrogenesis type II is a rare autosomal dominant skeletal dysplasia with a frequency of ~0.2 per 100,000 births. It is one of the lethal short-limbed dwarfisms associated with structural mutations in type II collagen and is also known as Langer-Saldino achondrogenesis. It is characterized by severe micromelia (shortening of entire limb), narrow chest, and prominent abdomen. It shares the striking feature of partial or complete vertebral body demineralization with achondrogenesis type I.

Case presentation
We present a case with antenatal diagnosis of this rare entity which was confirmed by post-termination radiographs of abortus.

Conclusion
The imaging plays a cardinal role in the diagnosis of this condition. This case represents only the 4th case of this rare entity from India.
CATCH: A Prospective Precision Oncology Trial in Metastatic Breast Cancer
Authors: Hlevnjak Mario , Schulze Markus , Elgaafary Shaymaa , Fremd Carlo , Michel Laura , Beck Katja , Pfütze Katrin , Richter Daniela , Wolf Stephan , Horak Peter , Kreutzfeldt Simon , Pixberg Constantin , Hutter Barbara , Ishaque Naveed , Hirsch Steffen , Gieldon Laura , Stenzinger Albrecht , Springfeld Christoph , Smetanay Katharina , Seitz Julia , Mavratzas Athanasios , Brors Benedikt , Kirsten Romy , Schuetz Florian , Fröhling Stefan , Sinn Hans-Peter , Jäger Dirk , Thewes Verena , Zapatka Marc , Lichter Peter , Schneeweiss Andreas 
Published: April 2021

PURPOSE CATCH (Comprehensive Assessment of clinical feaTures and biomarkers to identify patients with advanced or metastatic breast Cancer for marker driven trials in Humans) is a prospective precision oncology program that uses genomics and transcriptomics to guide therapeutic decisions in the clinical management of metastatic breast cancer. Herein, we report our single-center experience and results on the basis of the first 200 enrolled patients of an ongoing trial. METHODS From June 2017 to March 2019, 200 patients who had either primary metastatic or progressive disease, with any number of previous treatment lines and at least one metastatic site accessible to biopsy, were enrolled. DNA and RNA from tumor tissue and corresponding blood-derived nontumor DNA were profiled using whole-genome and transcriptome sequencing. Identified actionable alterations were brought into clinical context in a multidisciplinary molecular tumor board (MTB) with the aim of prioritizing personalized treatment recommendations. RESULTS Among the first 200 enrolled patients, 128 (64%) were discussed in the MTB, of which 64 (50%) were subsequently treated according to MTB recommendation. Of 53 evaluable patients, 21 (40%) achieved either stable disease (n = 13, 25%) or partial response (n = 8, 15%). Furthermore, 16 (30%) of those patients showed improvement in progression-free survival of at least 30% while on MTB-recommended treatment compared with the progression-free survival of the previous treatment line. CONCLUSION The initial phase of this study demonstrates that precision oncology on the basis of whole-genome and RNA sequencing is feasible when applied in the clinical management of patients with metastatic breast cancer and provides clinical benefit to a substantial proportion of patients.
Between Two Funerals: Zombie Temporality and Media Ecology in Japan
Authors: Zahlten Alexander 
Published: April 2021

AbstractThis article explores the popular shift to a media-ecological understanding in post-1960s Japan. Bookending its investigation with two actual funerals held for fictional characters in 1970 and 2007, it tracks the trope of death to map the increased interlocking of media temporality and everyday temporality in intensified media capitalism. As characters attain the ability to die, they are increasingly reanimated (to die again) in other media. Death and reanimation thereby become an expression of transformations at the intersection of media-systemic, economic, and aesthetic levels. The article concludes that death and reanimation across media channels point to a new rhythmic temporal regime. Characters are now mortal but cannot die, doomed to become eternally wandering media-mix zombies. The article relates this media economy linked to themes of death and animation to recent discussions of capitalist animism by figures such as Michael Taussig, Achille Mbembe, and Steven Shaviro. The article then offers a brief outlook on the most recent expressions of this zombie economy in narrative tropes of time loops and alternative realities.
On the Receptor Function of the Swim Bladder of Fishes
Authors: Koshtojanz CH. S. , Vassilenko PH. D. 
Published: April 2021

ABSTRACT
In spite of extensive investigation of the function of the swim bladder of fishes, our knowledge of the physiological role of this organ is far from complete. Two functions are usually ascribed to the swim bladder, viz. a participation in the co-ordination of the movements of fishes, and a participation in the act of breathing. Recent research has made it evident that the secretion of gas by those fishes which possess a red body in their bladder and the introduction of air into the bladder of those which have no red body provide stimuli which are capable of modifying to a marked degree the locomotory responses of the animals. The present paper constitutes an attempt to investigate the physiological mechanism by means of which the swim bladder performs this role.
Clinical Analysis of Interventional Therapy for Eight Cases of Extracranial ICA Aneurysm
Authors: Xu Jian-Feng , Liu Zao-Bin , Wang Tong , Liu Yang 
Published: April 2021

Objective: To explore the interventional therapy and clinical efficacy of extracranial ICA aneurysm.
Methods: The clinical data of eight patients with extracranial ICA aneurysm treated by interventional stent implantation from December 2014 to February 2018 in the Neurosurgery Department of the Third Hospital of Mianyang were analyzed. And this research was a retrospective analysis. All patients underwent digital subtraction angiography (DSA) and were diagnosed with extracranial carotid artery aneurysm. These patients, therefore, were treated with interventional stent implantation.
Results: Interventional treatment was successfully conducted on all eight patients. In eight patients, the aneurysm cavity was not developed immediately after angiography, and in one case, the aneurysm cavity was developed with coil-assisted embolization. All the internal carotid arteries were well developed, with no complications such as intraoperative rupture, bleeding and thrombosis occur. Follow-up for three months to two years showed that the patients recovered well, the GOS score was 4 points for patients with cerebral infarction, and the rest reached five points. Follow-up CTA showed no signs of aneurysm recurrence or ICA restenosis.
Conclusion: Interventional stent placement is a preferable and relatively safe method for the treatment of extracranial carotid artery aneurysm with less trauma and short operation time.
doi: https://doi.org/10.12669/pjms.37.4.3957
How to cite this:Xu JF, Liu ZB, Wang T, Liu Y. Clinical Analysis of Interventional Therapy for Eight Cases of Extracranial ICA Aneurysm. Pak J Med Sci. 2021;37(4):1086-1092. doi: https://doi.org/10.12669/pjms.37.4.3957
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Associations between dialysate interleukin-6 and Tie-2 and peritoneal solute transport rate and outcomes for patients undergoing peritoneal dialysis: A prospective cohort study
Authors: Hang Ying , Yan Hao , Zhang He , Li Zhenyuan , Fang Wei 
Published: April 2021

Objectives: We designed this prospective observational study to clarify the associations between dialysate IL-6, a marker of ongoing peritoneal inflammation, Tie2, an important factor in angiogenesis in the peritoneum, and a high peritoneal solute transport rate (PSTR) in patients undergoing peritoneal dialysis (PD) and to investigate their outcome predictive roles.
Methods: A total of 60 stable continuous ambulatory peritoneal dialysis (CAPD) patients from a single center in China were analyzed in this prospective study. We measured dialysate levels of IL-6 and Tie-2 using ELISAs. Our primary study endpoint was all-cause mortality with 10 years’ follow-up.
Results: For the evaluation of PSTR, we used the Dialysis/Plasma creatinine (D/Pcr) ratio. We subdivided the patients into two groups for statistical evaluation: low and low average D/Pcr (<0.64; L/A), and high and high average D/Pcr (≥0.65; H/A) transporters. The mean levels of dialysates IL-6 (21.71 ± 8.88 pg/mL) and Tie-2 (1.23 ± 0.43 ng/mL) were significantly higher in the H/A (high and high average, group than those in the L/A group (13.94 ± 5.43 pg/mL, p<0.001 and 0.95 ± 0.43 ng/mL, p=0.019; respectively). Moreover, IL-6 and Tie-2 were positively correlated with D/Pcr (r=0.366, p=0.004 and r=0.402, p=0.001; respectively). Both dialysates IL-6 and Tie-2 were independent determinants of a high peritoneal solute transport rate. After follow-up for 42.65±18.08 months, 30 patients (50.0%) had died. An increased D/Pcr increased the risk of all-cause mortality in patients with CAPD (p=0.018), but the dialysates IL-6 and Tie2 were not independent predictors of all-cause mortality (p>0.05).
Conclusion: Our results suggest that patients undergoing CAPD have a high peritoneal solute transport status with local peritoneal inflammation and angiogenesis. Increased D/Pcr is a relative risk factor for mortality and technique failure in patients undergoing CAPD.
doi: https://doi.org/10.12669/pjms.37.4.4328
How to cite this:Hang Y, Yan H, Zhang H, Li Z, Fang W. Associations between dialysate interleukin-6 and Tie-2 and peritoneal solute transport rate and outcomes for patients undergoing peritoneal dialysis: A prospective cohort study. Pak J Med Sci. 2021;37(4):1104-1110. doi: https://doi.org/10.12669/pjms.37.4.4328
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Association between attendance at a specialist palliative care day unit and improvement in patient symptoms and quality of life
Authors: Reed Jacqueline , O'Hara Mary , O'Sullivan Elizabeth , Cobbe Sinead , Reilly Martina O’ 
Published: April 2021

Background: Specialist palliative day care is an area of palliative care which has a notable scarcity of research. Evidence is needed on the role of palliative day care to improve patients' quality of life and symptom management, while recognising the different patient cohorts that use the service. Aim: To determine the symptoms and quality of life of the patient cohort that are affected by the completion of a full therapeutic cycle (8 to 9 weeks) at a specialist palliative care day unit (SPCDU). Method: A retrospective cohort study was carried out from January 2016 to December 2017. Patient related outcome measures (PROMs) were collected as part of routine clinical paperwork at admission and discharge, and these were used to determine symptoms and quality of life pre-attendance and on completion of an 8 to 9 week therapeutic cycle at the SPCDU. Results: Descriptive analysis demonstrated improvement across the many symptoms that were analysed. Quality of life analysis also established improvement. Statistically significant difference was achieved in several areas. Total physical symptoms (p value=.009) confirmed the positive impact attendance at SPCDU has on physical symptoms. Specific symptoms which displayed a statistically significant difference included: poor appetite (p value=.002), weakness (p value=.03) and the anxiety felt by family/friends (p value=.029). The quality of a patient's life also displayed statistically significant difference (p value=.000). Conclusion: This study demonstrates that attendance at a SPCDU may positively impact a patients' symptoms and quality of life. A more uniform national approach to specialist palliative day care delivery, alongside multi-setting research, may further bolster the image of palliative day care. This will improve referrals to and occupancy of SPDCUs and benefit the palliative patient in the community.