bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring interleukin-6, lipopolysaccharide-binding protein and brain-derived neurotrophic factor following 12 weeks of adjunctive minocycline treatment for depression
Authors: Hasebe Kyoko , Mohebbi Mohammadreza , Gray Laura , Walker Adam J. , Bortolasci Chiara C. , Turner Alyna , Berk Michael , Walder Ken , Maes Michael , Kanchanatawan Buranee , Ashton Melanie M. , Berk Lesley , Ng Chee H. , Malhi Gin S. , Singh Ajeet B. , Dean Olivia M. 
Published: December 2021

AbstractThis study aimed to explore effects of adjunctive minocycline treatment on inflammatory and neurogenesis markers in major depressive disorder (MDD). Serum samples were collected from a randomised, placebo-controlled 12-week clinical trial of minocycline (200 mg/day, added to treatment as usual) for adults (n = 71) experiencing MDD to determine changes in interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) and brain derived neurotrophic factor (BDNF). General Estimate Equation modelling explored moderation effects of baseline markers and exploratory analyses investigated associations between markers and clinical outcomes. There was no difference between adjunctive minocycline or placebo groups at baseline or week 12 in the levels of IL-6 (week 12; placebo 2.06 ± 1.35 pg/ml; minocycline 1.77 ± 0.79 pg/ml; p = 0.317), LBP (week 12; placebo 3.74 ± 0.95 µg/ml; minocycline 3.93 ± 1.33 µg/ml; p = 0.525) or BDNF (week 12; placebo 24.28 ± 6.69 ng/ml; minocycline 26.56 ± 5.45 ng/ml; p = 0.161). Higher IL-6 levels at baseline were a predictor of greater clinical improvement. Exploratory analyses suggested that the change in IL-6 levels were significantly associated with anxiety symptoms (HAMA; p = 0.021) and quality of life (Q-LES-Q-SF; p = 0.023) scale scores. No other clinical outcomes were shown to have this mediation effect, nor did the other markers (LBP or BDNF) moderate clinical outcomes. There were no overall changes in IL-6, LBP or BDNF following adjunctive minocycline treatment. Exploratory analyses suggest a potential role of IL-6 on mediating anxiety symptoms with MDD. Future trials may consider enrichment of recruitment by identifying several markers or a panel of factors to better represent an inflammatory phenotype in MDD with larger sample size.
Pain and suicide: what should we tell our trainees?
Authors: Pakniyat-Jahromi Soroush , Korenis Panagiota , Sher Leo 
Published: December 2021

AbstractChronic pain is a debilitating medical condition affecting a significant percentage of the population worldwide. Considerable evidence suggests that pain is an independent risk factor for suicide and inadequately managing pain has been identified as a risk for suicidal behaviour. Additionally, medications used to treat pain may also contribute to suicidal behaviour. Extensive research on pain highlights deficiencies in the clinical management on pain with more gaps in care when patients have pain in combination with mental illness and suicidal behaviour. Providing trainees additional knowledge and equipping them with relevant tools to screen and manage chronic pain efficiently is a potential strategy to mitigate suicide risk. Also, trainees need to be educated on how to screen for suicidality in individuals with pain and apply suicide prevention interventions. This paper will emphasise the necessity to improve education about pain, its close relationship with suicide and effective suicide screening as well as management strategies for medical providers. With additional research, it is the hope that novel treatment modalities will be developed to treat pain to improve the quality of life of individuals suffering from this condition and to decrease suicide risk in this patient population.
The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study
Authors: Vlachos George S. , Yannakoulia Mary , Anastasiou Costas A. , Kosmidis Mary H. , Dardiotis Efthimios , Hadjigeorgiou Georgios , Charisis Sokratis , Sakka Paraskevi , Stefanis Leonidas , Scarmeas Nikolaos 
Published: December 2021

AbstractVery few data are available regarding the association of adherence to the Mediterranean Diet (MeDi) with Subjective Cognitive Decline (SCD) evolution over time. A cohort of 939 cognitively normal individuals reporting self-experienced, persistent cognitive decline not attributed to neurological, psychiatric or medical disorders from the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD study) was followed-up for a mean period of 3·10 years. We defined our SCD score as the number of reported SCD domains (memory, language, visuoperceptual and executive), ranging from 0 to 4. Dietary intake at baseline was assessed through a food frequency questionnaire; adherence to the MeDi pattern was evaluated through the Mediterranean Diet Score (MDS) that ranged from 0 to 55, with higher values indicating greater adherence to the MeDi. The mean SCD score in our cohort increased by 0·20 cognitive domains during follow-up. After adjustment for multiple potential confounders, we showed that an MDS higher by 10 points was associated with a 7% reduction in the progression of SCD within one year. In terms of food groups, every additional vegetable serving consumption per day was associated with a 2·2% reduction in SCD progression per year. Our results provide support to the notion that MeDi may have a protective role against the whole continuum of cognitive decline, starting at the first subjective complaints. This finding may strengthen the role of the MeDi as a population-wide, cost-effective preventive strategy targeting the modifiable risk factors for cognitive decline.
Growth rate and behaviour in separated, partially separated or non-separated kids and the corresponding milk production of their mothers
Authors: Högberg Madeleine , Winblad von Walter Louise , Hydbring-Sandberg Eva , Forkman Björn , Dahlborn Kristina 
Published: December 2021

AbstractWe address the hypothesis that keeping kids and mothers together would have positive effects on the milk composition of the mother and the behaviour of the kids. Kids were either permanently separated (SEP), daily separated between 7.30 and 15 h (DAY-SEP) or kept with mothers 24 h/d (NON-SEP). The NON-SEP kids were only allowed to suckle one teat. All kids had similar growth rate throughout the study (lactation days 5–70). DAY-SEP kids spent 24% of their time with their mother at both ages. NON-SEP spent only 15% of the time with their mothers at 2 weeks of age and this increased to 28% at 2 months of age. NON-SEP kids showed more hiding behaviour at 2 weeks and SEP were more active alone, at both 2 weeks and 2 months, compared to the other treatments. The mean available milk yield and fat concentration were higher in DAY-SEP goats (2420 g ± 119 g and 4.9 ± 0.1%) compared with NON-SEP goats (2149 ± 79 g and 4.4 ± 0.1%). There were no differences between DAY-SEP and NON-SEP goats in total protein, lactose, or casein concentrations. Based on these data it was estimated that 7.1 kg milk was needed to produce 1 kg semi-hard cheese in DAY-SEP goats and 7.5 kg in NON-SEP goats, respectively. When comparing milk yield and composition between udder halves, the milk yield was, as expected, higher from the machine milked teat than from the suckled one in the NON-SEP goats but there was no difference between right and left udder halves in DAY-SEP goats. Milk fat concentration varied between teats at morning and afternoon milkings in NON-SEP goats, but there was no difference in milk fat between udder-halves in DAY-SEP goats. In conclusion, the kid growth rate was similar in all treatments, however, an altered behaviour was seen in permanently separated kids (SEP). The results show that it is possible to have a high milk yield and fat concentration with one kid together with the dam.
Gramian-constrained optimization process for the stiffness model identification of industrial manipulators
Authors: Oliveira W. R. , Trabasso L. G. 
Published: December 2021

AbstractThis work deals with the elastostatic identification of industrial manipulators. By reviewing the basics of the physical elastic properties of both links and joints in the framework of the lumped stiffness modeling techniques, the Gramian nature of the stiffness matrices has been found out adequate to do so. Then, a novel optimization method has been developed, which incorporates the Gramian matrix formulation along a non-linear optimization process, acting as an intrinsic constraint for the conservativeness of the elastostatic modeling. Numerical and experimental analyses evince the effectiveness of the proposed method, as the elastostatic models obtained by means of the proposed technique predict more than 93.7% of the compliance deviations of a real industrial robot. The proposed method is simple enough to be jointly applicable to the most recent elastostatic model reduction techniques.
Advertising patterns of a fast-food chain on social media in Brazil
Authors: da Silva Jéssica Moreira , Matos Juliana de Paula , Rodrigues Michele Bittencourt , Mais Laís Amaral , Claro Rafael Moreira , Horta Paula Martins 
Published: December 2021

AbstractObjective:To investigate the advertising patterns on the posts of a fast-food chain in Brazil on three social media platforms in 2019.Design:An exploratory cross-sectional study.Setting:Advertising strategies on the posts of a major fast-food chain on their official Facebook, Instagram and YouTube accounts. The strategies were investigated according to the INFORMAS protocol for food promotion monitoring. Principal component analysis (PCA) was employed to identify advertising patterns in each platform.Participants:305 advertisementsResults:Four advertising patterns were identified in the PCA of Facebook and Instagram. In both platforms, the components for kids and product exaltation were similar. On Facebook, a pattern corresponding to economic appeal was identified as price and discount, while on Instagram, this pattern also included a practical approach. On Facebook, the fourth component was named celebrity, while on Instagram it was celebrity/innovation since on this second social media the component also included the ‘new brand development’ variable. On YouTube, three advertising patterns were identified in PCA. Similar to the other platforms, the first and the second patterns were called for kids and price and discount, and the third component referred to both celebrity and commemorative dates.Conclusions:The advertising patterns of the fast-food chain on three social media platforms were commonly directed to children and addressed price, discounts and the celebrities’ universe. The findings of this study corroborate other data in the literature regarding unhealthy food advertising on social media. This study discusses the urgency of regulating food advertising content on this medium.
The Case for Coordinating Earth & Space Science Education Worldwide
Authors: Waller William H. 
Published: December 2021

AbstractDespite the many amazing advances that have occurred in the space sciences (planetary science, heliophysics, astronomy, and cosmology) these subjects continue to play minor roles in pre-collegiate science education. Similarly, the Earth sciences are woefully under-represented in most school science programs – despite their vital relevance to our physical well-being. Some countries have educational standards that formally prioritize the Earth & space sciences as much as the physical and life sciences, but even they fail to actualize their mandated priorities. I contend that better coordination and advancement of Earth & space science education at the national, state, society, and educator levels would lead to better educational outcomes worldwide.
The oldest astronomical observatories in Ukraine
Authors: Vavilova I.B. , Artemenko T.G. 
Published: December 2021

AbstractWe present the data related to the revealed astronomical oldest observatories at the territory of Ukraine and describe briefly the principles of observations which could be realized at these sites with usage of megalithic stones. Among these oldest observatories are as follows: the stone complex at the Lysyna Kosmatska mountain (Charpatian region); Bakhchysaray Menhir in Crimea; a complex of shafts at the Mavrin Maidan near Pavlograd city.
The sample of eight LLAGNs: X-ray properties
Authors: Pulatova Nadiia G. , Tugay Anatoliy V. , Zadorozhna Lidiia V. 
Published: December 2021

AbstractLLAGN are very important objects for studying as they are found in a large fraction of all massive galaxies. Nevertheless this topic needs more investigation as fraction of LLAGN in all AGN are much more higher than fraction of researches dedicated to LLAGN among all AGN studies. The goal of our work is checking out X-ray properties of LLAGN. For this purpose we created a sample of LLAGN by selecting most prominent LLAGN from literature and analyzed their X-ray spectral properties. As a result, we obtained 12 LLAGN and for 8 of them XMM X-ray observations are available. The spectra from one XMM camera, PN, were fitted with power law + absorption of neutral hydrogen. In the current report we present the previous results of this study. We plan to increase numbers of objects in our future studies.
The right to the night sky in punitive enclosure context
Authors: Guevara Natalia , Haack Rodrigo F. , Acosta Victoria B. , Senn María A. , Silva Carolina A. , Adamson Rocío , Ruta Jeremias , Gómez Natalia M. , Brellis Karen A. , Puga Marina S. , De Bortoli Bruno J. , Pallazo Fiamma S. , Lizzi Ayelén 
Published: December 2021

AbstractThe “Right to the night sky” outreach project holds astronomy workshops for children and teens deprived of their liberty in juvenile detention centers. It is carried out by an interdisciplinary group of students, graduates, and teachers of Astronomy, Geophysics, Educational Science, Law, Psychology, Social Work, and Social Communication. It’s has been accredited and recognized by the Faculty of Astronomical and Geophysical Sciences, and the National University of La Plata (Argentina) since the year 2014. This work presents the diverse activities developed in the project, the methodologies used, and an analysis of how the project evolved, grew, and expanded over time, continuing what has already been presented by Charalambous et al. (2014) and Haack et al. (2019)
Astronomy in The Malaysian National School Syllabus
Authors: Aimran Wan Mohd , Kamil Wan Mohd 
Published: December 2021

AbstractThis is a preliminary survey of astronomy topics incorporated into the Malaysian national school syllabus. Topics directly relevant to astronomy are situated within the general science subject from Year 4 (age 10 years old) until Year 9 (age 15 years old) and are grouped under four main themes: Earth-Sun-Moon system, the Solar System, Stars, and Exploration of Outer Space. Contemporary topics such as exoplanets and astrobiology are not explicitly mentioned, but students are required to engage in hypothetical thinking by speculating on planetary diversity and its implications for life in the Universe. We characterize the astronomy content in the Malaysian national school syllabus to be life-centric and relatively open-ended.
Basics of Astrophysics in primary school: Marvel, play and learn
Authors: Torres-Campos Ana 
Published: December 2021

AbstractIn this poster is presented the development and testing of a pilot project to teach basics of astronomy to primary school students. This is a learning program that bases on the interdisciplinary nature of astronomy with amusing and playful activities. The objective of the programme is to engage children in astronomy and make them aware of the importance of the development of science and technology for society. The program has been tested a small non-government-funded school in the state of Puebla, in Mexico. Due COVID-19 lockdown the classes had to switch from face-to-face to online. Over 80% of the students that completed the course had considerably increased their knowledge of astronomy and requested to continue with the classes on the next school term.
Solar Eclipse: a didactic alternative for education in Astronomy
Authors: Sebben Viviana , Romagnoli Claudia 
Published: December 2021

AbstractThis article presents a didactic experience in teacher training carried out in the province of Santa Fe, Argentina. The training was carried out on the occasion of a total solar eclipse taking place in this region on July 2, 2019. Prior to this event, the authors, members of NASE, developed training meetings of the Ministry of Education of Santa Fe , on topics of Astronomy. From these workshops, participants of all educational levels with different specialties, carried out with their students school science activities where they applied Astronomy with an interdisciplinary perspective. In this way, the eclipse became an event that made possible an enrichment of astronomical education in the region.
Research, innovation, scientific literacy and inclusion in astronomy
Authors: Lanciano Nicoletta , Ortiz-Gil Amelia , Camino Néstor 
Published: December 2021

AbstractWith this roundtable we wished to discuss about different topics related to research, innovation, scientific literacy and inclusion in Astronomy education, putting together the expertise of educators from all around the world. The present paper includes the introduction to the roundtable prepared by the chairs of the session as well as the contributions from several of the participants.
Accessible Astronomy Activities for the Blind and Visually Impaired in Puerto Rico
Authors: Isidro Villamizar Gloria M. , Pantoja Pantoja Carmen A. , Lebrón Santos Mayra E. 
Published: December 2021

AbstractWe present the design and development of accessibleWe have shortened the running head. Please check. activities in astronomy for blind persons in Puerto Rico. We design for a diverse audience that sees from different perspectives, but with the same purpose: to know and discover the Universe. We adapt tactile materials to develop themes that require visual images. We design and develop three-dimensional tactile material to offer blind people the opportunity to get the conceptual idea of the specific topic under consideration. Listening and designing bearing in mind the voice of blind people with their different life experiences is essential. Through years of experience (2006 – 2020) we have learned to use new strategies in the design and development of tactile materials. We recognize that what we have achieved to date has been possible through the exchange of efforts, collaboration, and volunteering. In recent months, we have been publishing videos with each of the tactile materials, with the purpose of contributing to the literacy of astronomy worldwide.
Japan Astronomical Heritage: The First Two Years
Authors: Horaguchi Toshihiro 
Published: December 2021

AbstractThe Astronomical Society of Japan has started authorization of Japan Astronomical Heritage since 2018. The society certificates two or three sites/materials/literature every year not only for preservation but also for utilization. The certification influences citizens and local governments, and stimulates various movements. The idea of national astronomical heritage will help to preserve valuable properties of each country and to promote the utilization.
The sky is the limit fifteen years of literacy in astronomy
Authors: Cabezas Daniel , Curcio Omar , De La Rosa Joaqun , Escudero Jorge , Fabbro José , Flores Daniel , Girola Rafael , Iglesias Patricia , Lucarelli Carlos , Pernicone Verónica , Plem José , Racchiusa Norma , Vinet Néstor 
Published: December 2021

AbstractEnDiAs is an argentine group of astronomy fans founded fifteen years ago, whose goal is the public dissemination of Astronomy through Non-Formal Education. We consider that the sky is a World Heritage and everyone should have access to its observation and study. This paper shows the activities carried out by EnDiAs to fulfill its goal.
Modeling astronomy education, the case of F-HOU tools : SalsaJ and Human Orrery
Authors: Rollinde Emmanuel 
Published: December 2021

AbstractThis communication introduces two cases of the use of astronomy as a motivating context to interdisciplinary science education with emphasis on modeling activities. Firstly, a dedicated software, called SalsaJ, allows students to reproduce the same data analysis as made by astronomers. The case of exoplanet detection will be used as an exemple. Secondly, bodies of learners are considered to model movements of planets with a Human Orrery (a Spatio-Temporal Map of the Solar System), connecting thus mathematics, physics, geography and arts.
Antofagasta: Astronomy education on the shoulders of giants
Authors: Unda-Sanzana Eduardo 
Published: December 2021

AbstractThis work presents the motivation, history and current status of the Primera Luz initiative, a long-term educational project run by researchers and professionals of the Astronomy Center (CITEVA) at Universidad de Antofagasta (UA, Chile), primarily focused on connecting Astronomy with the people living in the Region of Antofagasta (Chile) but producing results designed to be shared with international audiences.
With Covid-19: Attempt of learning to observe the moon using a telescope at home
Authors: Agata Hidehiko 
Published: December 2021

AbstractStudents took an assembly-type telescope kit from a public elementary school and brought it to their homes in 2019. Three classes attempted to observe the Moon at home using the Kaifu-NAOJ Telescope Kit. As a result, all children observed the Moon at home using the kit. From their observations, around 90% identified the existence of craters and understood the reflection of sunlight on the Moon’s surface. As Covid-19 prevention measures in education, we propose the introduction of at-home telescopic observations for STEAM activities.
Outreach in the era of big data with the Pierre Auger Observatory
Authors: Caballero-Mora Karen S. ,   for the Pierre Auger Collaboration
Published: December 2021

AbstractThe Pierre Auger Observatory, built to study the physics of astroparticles, has expanded its endeavours in outreach and education. Since its inception, the collaboration has been informing the general public about its discoveries. From creating a visitor center in Malargüe, Argentina, to providing talks for different audiences, science fairs for students, international measurement workshops, and making compilations of the scientific contributions of women in different countries throughout history, we share the passion for science with the population. The collaboration processes a huge amount of data and requires a large storage capacity. However, 10% of this data is made available to the general public in a useable format. The collaboration developed special masterclasses aimed at high school students, providing the software that can be used to analyse the public data set. In addition, a summary of the different outreach activities performed by the members of the Pierre Auger Collaboration will be presented.
Solar eclipses in India’s cultural and political history
Authors: Kapoor R. C. 
Published: December 2021

AbstractThis contribution presents earliest records in the Indian stone inscriptions and literature that specifically mention the eclipse as total or annular and the eclipses that timed with wars. Solar cult temples can be found all over India. In a few, the assigned dates coincide or are close to the dates of solar eclipses of large magnitude in the area.