bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrahigh Molecular Weight Polyethylene Lamellar‐Thin Framework on Square Meter Scale
Authors: Sun Weilong , Yang Kailin , Wang Zirui , Niu Mingze , Luo Tao , Su Zhaoming , Li Runlai , Fu Qiang 
Published: November 2021

AbstractA new member of low‐dimensional structures with a high aspect ratio (LDHA) is introduced. For the first time, commodity polymer is processed into LDHA, which has long been stagnated by the lack of suitable processing techniques. The key to solve the current bottleneck is to overcome the trade‐off between kinetic processability and thermodynamic stability. These two factors are both highly determined by intermolecular interaction level (IIL). Thus with a wide tuning range of IIL, ultrahigh molecular weight polyethylene (UHMWPE) is selected and investigated to break through the trade‐off. Polymeric LDHA preparation needs both thinning and stiffening. By focusing on one then the other sequentially, they are realized simultaneously. Thus the over sixty‐year‐old material is finally thinned down by seven orders of magnitude into a 65.5 nm thick and 0.64 m2 large lamellar‐thin framework (LTF). LTF exhibits a series of exceptional properties such as over‐95% transparency, and seven times higher specific strength referred to steel. For the first time, cryogenic electron microscopy (Cryo‐EM) is utilized to observe commodity polymers directly. This new LDHA material is promising to expand the scale boundaries of both fundamental research and practical applications, not only for UHMWPE, but also for more commodity polymers to come.
Near‐Infrared Multilayer MoS2 Photoconductivity‐Enabled Ultrasensitive Homogeneous Plasmonic Colorimetric Biosensing
Authors: Park Younggeun , Ryu Byunghoon , Ki Seung Jun , Liang Xiaogan , Kurabayashi Katsuo 
Published: November 2021

AbstractThe ability to detect low‐abundance proteins in human body fluids plays a critical role in proteomic research to achieve a comprehensive understanding of protein functions and early‐stage disease diagnosis to reduce mortality rates. Ultrasensitive (sub‐fM), rapid, simple “mix‐and‐read” plasmonic colorimetric biosensing of large‐size (≈180 kDa) proteins in biofluids using an ultralow‐noise multilayer molybdenum disulfide (MoS2) photoconducting channel is reported here. With its out‐of‐plane structure optimized to minimize carrier scattering, the multilayer MoS2 channel operated under near‐infrared illumination enables the detection of a subtle plasmonic extinction shift caused by antigen‐induced nanoprobe aggregation. The demonstrated biosensing strategy allows quantifying carcinoembryonic antigen in unprocessed whole blood with a dynamic range of 106, a sample‐to‐answer time of 10 min, and a limit of detection of 0.1–3 pg mL−1, which is ≈100‐fold more sensitive than the clinical‐standard enzyme‐linked immunosorbent assays. The biosensing methodology can be broadly used to realize timely personalized diagnostics and physiological monitoring of diseases in point‐of‐care settings.
Simultaneous Synthesis, Modification, and DFT Calculation of Three‐Color Lead Halide Perovskite Phosphors for Improving Stability and Luminous Efficiency of WLEDs
Authors: Sun Yao , Li Yini , Zhang Wanying , Zhu Peifen , Zhu Hongyang , Qin Weiping , Wang Guofeng 
Published: November 2021

AbstractThe all‐inorganic metal halide perovskite CsPbX3 (X = Cl, Br, and I) has received extensive attention in the field of white light‐emitting diodes (WLEDs) due to its high luminous intensity and high color purity. However, the shortcoming of poor stability directly affects the luminous performance of the WLED devices and reduces their luminous efficiency, which has become an urgent problem to be solved. Here, three‐color lead halide perovskite phosphors (blue‐emitting CsPbBr3 synthesized at 20 °C (CPB‐20), green‐emitting CsPbBr3‐80 (CPB‐80)/CsPbBr3:SCN−(CPB:SCN−), and red‐emitting PEA2PbBr4 (PPB)/PEA2PbBr4:Mn2+ (PPB:Mn2+)) with higher stability and luminous intensity are simultaneously prepared and applied in WLEDs. Density functional theory is used to optimize the structures of CsPbBr3 and PEA2PbBr4, and to calculate the work function, optical properties, and charge density difference. Not only the WLED devices with three‐color lead halide perovskite phosphors are constructed, but also WLED devices from warm white to cold white are realized by tuning the ratio of the different emissions, and a superior color quality (color rendering index of 96) and ideal correlated color temperature (CCT of 9376 K) are achieved. This work will set the stage for exploring low‐cost, environmentally friendly, high‐performance WLEDs.
Noble Metal‐Based Multimetallic Nanoparticles for Electrocatalytic Applications
Authors: Kim Hyunjoong , Yoo Tae Yong , Bootharaju Megalamane S. , Kim Jeong Hyun , Chung Dong Young , Hyeon Taeghwan 
Published: November 2021

AbstractNoble metal‐based multimetallic nanoparticles (NMMNs) have attracted great attention for their multifunctional and synergistic effects, which offer numerous catalytic applications. Combined experimental and theoretical studies have enabled formulation of various design principles for tuning the electrocatalytic performance through controlling size, composition, morphology, and crystal structure of the nanoparticles. Despite significant advancements in the field, the chemical synthesis of NMMNs with ideal characteristics for catalysis, including high activity, stability, product‐selectivity, and scalability is still challenging. This review provides an overview on structure‐based classification and the general synthesis of NMMN electrocatalysts. Furthermore, postsynthetic treatments, such as the removal of surfactants to optimize the activity, and utilization of NMMNs onto suitable support for practical electrocatalytic applications are highlighted. In the end, future direction and challenges associated with the electrocatalysis of NMMNs are covered.
Atezolizumab‐associated colitis mimic inflammatory bowel disease: A case report
Authors: Liu Yen‐Chun , Chiu Cheng‐Tang , Wu Ren‐Chin , Hsu Chao‐Wei , Chen Chun‐Wei , Le Puo‐Hsien , Kuo Chia‐Jung 
Published: November 2021

AbstractImmune checkpoint inhibitors (ICIs) are monoclonal antibodies that target downregulators of the anticancer immune response. ICIs have revolutionized the treatment of various malignancies. However, many immune‐related adverse events have also been described, which mainly occurs when the immune system becomes less suppressed, and affects various organs, including the gastrointestinal tract. We report a case of atezolizumab‐associated colitis with clinical and endoscopic follow‐ups. The patient was a 72‐year‐old male diagnosed with advanced squamous cell lung cancer treated with atezolizumab and combination chemotherapy. Two months after atezolizumab therapy, bloody diarrhea and abdominal pain were reported. Initial colonoscopy revealed colonic ulcers with diffuse erythema and loss of vascularity. Histology demonstrated ulcerated mucosa with acute inflammation. Steroids were promptly indicated due to suspicion of immune‐related colitis caused by atezolizumab. Follow‐up sigmoidoscopy performed 6 weeks after initiating steroid therapy showed improvement of inflammation. Histological findings revealed eroded colonic mucosa with abortive crypts, lymphoplasma, and eosinophil cell infiltration, which mimicked inflammatory bowel disease (IBD). However, there was no colitis relapse after steroid discontinuation. The case demonstrated endoscopic and histological presentations of immune‐mediated colitis that mimicked IBD.
Synthesis of self‐healing supramolecular waterborne polyurethane with quadruple hydrogen bonds via ureidotriazine
Authors: Liu Hao , Sun Dongcheng 
Published: November 2021

AbstractA supramolecular waterborne polyurethane (SWPU) with excellent mechanical and self‐healing properties simultaneously is reported in this work. Herein, the SWPU were synthesized by using 2,4‐diamino‐6‐undecyl‐1,3,5‐triazine react with isophorone diisocyanate to introduce ureidotriazine (UTr) structures into the main chain of polyurethane that can self‐assemble to form quadruple hydrogen bonds systems. A higher dimerization constant obtained through introducing two intramolecular hexatomic ring hydrogen bonds into the UTr structure, and the hydrophobicity, plasticity brought by the undecyl group on the triazine ring are beneficial to make a great balance between the binding strength for mechanical performance and the chain reversibility, mobility for self‐healing. Owing to the accuracy design, the SWPU exhibits high tensile stress (33.85 MPa) and excellent self‐healing ability (90.52%), which shows an enormous application potential in the field of functional coatings and adhesives.
Tuning response amplitude in nanoimprinted thermoresponsive polymer blend
Authors: Sargur Ranganath Anupama , Vellingiri Suganya , Low Hong Yee 
Published: November 2021

AbstractWe demonstrate the potential of thermoresponsive poly N‐(isopropylacrylamide) (PNIPAM) based surfaces in achieving a low‐energy approach to modulate surface wetting for applications such as fog harvesting and anti‐fogging. Alternative to grafting methods, we use a two‐step approach for tuning the response amplitude. First, we blend PNIPAM with a chemically non‐reactive poly (vinylidene fluoride), PVDF (1/3, 1/1, 3/1 by weight). Second, thermal nanoimprint lithography is used to create micro (3, 5, 10, and 20 μm) and nano‐scale (100 and 200 nm) pillars. Nano‐patterned surfaces show a response amplitude of ~30°–50° compared to ~15°–30°, observed for the micro‐patterned surface. X‐ray photo‐electron spectroscopy and energy dispersive X‐ray analysis confirms the reduction of polyvinylidene fluoride phase domains and enrichment of PNIPAM on the nano‐patterned surface. A real‐time dynamic mist condensation study showed that the nano‐patterned blend exhibited a lower temperature range (34/41°C) for on/off (wetting/drying) state compared to an unpatterned blend (37/50°C).
Resolved simulations of jet–ISM interaction: Implications for gas dynamics and star formation
Authors: Mukherjee Dipanjan , Bicknell Geoffrey V. , Wagner Alexander Y. 
Published: November 2021

AbstractRelativistic jets can interact with the ambient gas distribution of the host galaxy, before breaking out to larger scales. In the past decade, several studies have simulated jet‐driven outflows to understand how they affect the nearby environment, and over what spatial and temporal scales such interactions occur. The simulations are able to capture the interaction of the jets with the turbulent clumpy interstellar medium and the resultant energetics of the gas. In this review, we summarize the results of such recent studies and discuss their implications on the evolution of the dynamics of the gas distribution and the star formation rate.
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Authors: Silva Valdenizia R. , Santos Luciano de S. , Dias Rosane B. , Quadros Claudio A. , Bezerra Daniel P. 
Published: November 2021

AbstractColorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self‐renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self‐renewal properties, and most of them are dysregulated in CSCs, including the Wingless (Wnt)/β‐catenin, Notch, Hedgehog, nuclear factor kappa B (NF‐κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), peroxisome proliferator‐activated receptor (PPAR), phosphatidyl‐inositol‐3‐kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR), and transforming growth factor‐β (TGF‐β)/Smad pathways. In this review, we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways, which will contribute to the study of potential therapeutic schemes, combining conventional drugs with CSC‐targeting drugs, and allowing better cure rates in anti‐CRC therapy.
First in‐human evaluation of a novel intravascular ultrasound and optical coherence tomography system for intracoronary imaging
Authors: Akl Elie , Pinilla‐Echeverri Natalia , Garcia‐Garcia Hector M. , Mehta Shamir R. , Dan Kazuhiro , Kuku Kayode O. , Courtney Brian K. , Sheth Tej 
Published: November 2021

AbstractAimsWe evaluated the first in‐human performance of a novel hybrid imaging catheter that permits simultaneous and co‐registered acquisition of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images.Methods and ResultsA total of 17 patients undergoing planned percutaneous coronary intervention (PCI) were imaged between August 2018 and August 2019. Eleven patients with both pre‐ and post‐PCI IVUS and OCT images were included in the offline image analysis. IVUS and OCT images were analyzed separately then together with co‐registered images for pre‐stent findings, and only separately for post‐stent findings. A total of 926 frames were analyzed (218 pre‐PCI, 708 post‐PCI). There was substantial agreement to detect calcific plaque between co‐registered IVUS‐OCT and standalone IVUS (Kappa 0.72 [0.65–0.79]) and standalone OCT (Kappa 0.75 [0.68–0.81]) while standalone imaging modalities showed lower agreement to detect lipidic and fibrotic plaques compared with co‐registered IVUS‐OCT. There were more frames with stent underexpansion on IVUS than OCT [72 (28.7%) vs. 58 (23.1%), respectively, p = 0.039]. Detection rates of incomplete stent apposition (present on 20 OCT frames vs. 2 IVUS frames, p < 0.001) and tissue protrusion (40 vs. 27 frames, p < 0.001) were higher on OCT than IVUS. One stent edge dissection was detected in the image analysis and was seen on OCT but not IVUS. All 177 frames with image artifacts contained at least one co‐registered imaging modality with interpretable diagnostic content. There were no study device‐related adverse events.ConclusionsHybrid image acquisition was safe. The availability of both IVUS and OCT changed image interpretation compared to either modality alone, suggesting a complementary role of these two techniques.
Electrochemical Sensitization of Activated Carbon by Microporous MOF for Supercapacitor Applications
Authors: Ali Aya , Basuni Mustafa , Soliman Ahmed B. , El‐Mehalmey Worood A. , Ibrahim Ahmed H. , El‐Bahry Mady , Alkordi Mohamed H. 
Published: November 2021

AbstractThe remarkable performance of activated carbon as active electrode material in supercapacitors enabled its large‐scale industrialization. Herein, the utilization of facile physical mixing process of microporous, chemically robust, Zr‐based metal‐organic framework for surface‐modification of activated carbon to enhance its charge retention capacitance is reported. In this approach, the high surface area of the microporous MOF increases the active surface area of the activated carbon, providing an extra layer with facilitated electrolyte diffusion properties that effectively modulates the solid–electrolyte interface. A critical optimal coverage of 5wt % by the MOF crystallites is identified, resulting in increased specific capacitance of the activated carbon by ∼80 %, as compared to the pristine carbon. At higher MOF coverage, the poor electronic conductivity of the MOF hindered the inter‐grain charge mobilization within the activated carbon, thus adversely affecting the overall capacitive performance.
Halogen Bonding Adsorbent Pyridine N‐oxides for Iodine Capture in Water
Authors: Wu Wen Xin , Liu Hu Cheng , Jin Wei Jun 
Published: November 2021

AbstractRapid capture of 129I with high volatility and toxicity in the environment has attracted much attention. Herein we reported a firstly synthesized nonporous material: pyridine N‐oxides (NTPO and ATPO) as iodine adsorbent. Both of NTPO and ATPO exhibit remarkable performance on the adsorption of iodine in aqueous solution, vapor state and organic solvents. Upon the capture of iodine, pyridine N‐oxides were transformed to binary cocrystals combined with the pyridine N‐oxides and iodine which is driven by halogen bond between iodine and oxygen atoms. Moreover, pyridine N‐oxides shows high chemical, thermal and moisture stability.
Rational Design of Self‐Assembled Mitochondria‐Targeting Lytic Peptide Conjugates with Enhanced Tumor Selectivity
Authors: Liu Sijin , Wang Biao , Sheng Yina , Dong Suwei , Liu Guoquan 
Published: November 2021

AbstractMembrane lytic peptides (MLP) are widely explored as cellular delivery vehicles or antitumor/antibacterial agents. However, the poor selectivity between cancer and normal cells slims their prospects as potential anti‐tumor drugs. Herein, we have developed a rationally designed self‐assembly strategy to enhance tumor selectivity of MLP‐based conjugates, incorporating a hydrophobic triphenylphosphonium (TPP) group for mitochondria targeting, and a hydrophilic arginine‐glycine‐aspartic acid (RGD) sequence targeting integrins. The self‐assembly nanoparticles can enhance the stability of the peptides in vitro plasma and be endocytosed selectively into the cancer cells. The histidine‐rich lytic peptide component assists the disruption of endosomal/lysosomal membranes and subsequent the mitochondria membrane, which leads to apoptosis. This rational design of MLP‐based conjugates provides a practical strategy to increase the application prospects of lytic peptides in cancer treatment.
Study on degradation of Cambodian panel painting during UV aging
Authors: Buntem Radchada , La Sokheng 
Published: November 2021

AbstractIn this research, the glue films, ground and paint layers were aged under UV‐C radiation. The glue films were prepared using tamarind gum and liang‐chey resin powders. The ground (calcium carbonate mixed with tamarind glue) and paint layers (red cinnabar, malachite, Prussian blue mixed with liang‐chey resin) were applied on the iron wood using traditional tempera technique. The degree of disintegration was determined using scanning electron microscopy with energy dispersive X‐ray instrumentation, thermogravimetric analysis, attenuated total reflectance Fourier transformed infrared spectroscopy and powder X‐ray diffraction. The tamarind film turned brown after 14 days. While, liang‐chey resin film did not show any significant color change. The thermogravimetric analysis showed the lower thermal stability of the aged tamarind film. The discoloration and cracking on the ground layer surface stemmed from the disintegration of tamarind binder. After 14‐day exposure, the color of red cinnabar changed from bright red to dark red with black spots all over the surface. These spots were identified by powder X‐ray diffraction measurements as β‐HgS (black). After prolonged UV exposure, the white solid was appeared on the cinnabar surface and identified as anhydrite (anhydrous CaSO4) and gypsum (CaSO4.2H2O). The yellow color appeared on the malachite surface might come from the discoloration of the tamarind glue binder in the ground layer. While the brown layer found on aged Prussian blue surface was confirmed as the mixture of β‐PbO2, Pb3O4, and β‐FeOOH.
Synthesis and Functionality Study of Photoswitchable Hydrazone Oligodeoxynucleotides
Authors: Chang Zhihua , Mao Song , Zheng Ya Ying , Sheng Jia 
Published: November 2021

AbstractThis article provides a detailed procedure for the chemical synthesis and characterization of photoswitchable hydrazone phosphoramidite and its incorporation into oligodeoxynucleotides. The synthesis starts with commercially available deoxyuridine, followed by conversion of the 4‐oxo into a 4‐chloro moiety via Appel reaction to install the key hydrazone group in the absence of base. The hydrazone phosphoramidite building block is compatible with the conventional amidite chemistry protocols for solid‐phase synthesis of oligodeoxynucleotides. Our method expands the current nucleotide pool by adding a novel, functional DNA building block that is suitable for a broad spectrum of applications, including the regulation of DNA‐enzyme interactions and DNA synthesis by irradiation with cell‐friendly blue light. © 2021 Wiley Periodicals LLC.Basic Protocol 1: Preparation of photoswitchable hydrazone phosphoramiditeBasic Protocol 2: Synthesis and purification of oligodeoxynucleotides containing the hydrazone photoswitchBasic Protocol 3: Primer extension assay for functionality studies of hydrazone cytidine
Oral health problems linked to obstructive sleep apnea are not always recognized within dental care—As described by dental professionals
Authors: Berggren Kristina , Broström Anders , Firestone Allen , Wright Bridget , Josefsson Eva , Lindmark Ulrika 
Published: November 2021

AbstractObjectivesObstructive sleep apnea (OSA) has an impact on an individual's quality of life and general health, and can also affect their oral health. The patient's experiences, together with intraoral signs and symptoms could indicate the presence of OSA. Knowledge that the patient has, or is at high risk for having OSA can help the dental healthcare provider maintain the oral health and general health for these patients. The purpose was to explore dentists and dental hygienists' experiences when encountering adult patients with potential, untreated and treated OSA.MethodsA qualitative inductive approach was used. Experienced dentists and dental hygienists working within Swedish Public Dental Service were strategically selected. Semi‐structured face‐to‐face interviews were performed followed by qualitative content analysis.ResultsInterviews from 13 participants, seven dental hygienist and six dentists, led to three areas describing varied experience: Importance of the patient encounter and identifying intraoral signs both of which describe experiences related to the importance of the initial unstructured conversation and focused clinical assessments, and strategies for nurturing care which point to interest about care, treatment, and collaborations with medical health care providers.ConclusionsDental professionals are not able to consistently recognize patients who have, or are at high risk for OSA. During the patient encounter, is it important to determine if a patient is at risk for, or has oral signs of OSA.