bluuebunny/crossref_metadata_2025_split huggingface dataset:
C–H activation by immobilized heterogeneous photocatalysts
Authors: Choi Isaac , Struwe Julia , Ackermann Lutz 
Published: November 2021

AbstractDuring the last decades, the merger of photocatalysis with transition metal chemistry has been surfaced as a sustainable tool in modern molecular syntheses. This Account highlights major advances in synergistic photo-enabled C‒H activations. Inspired by our homogenous ruthenium- and copper-catalyzed C‒H activations in the absence of an exogenous photosensitizer, this Account describes the recent progress on heterogeneous photo-induced C‒H activation enabled by immobilized hybrid catalysts until September 2021, with a topical focus on recyclability as well as robustness of the heterogeneous photocatalyst.
Address by the President of The International Astronomical Union
Authors: Oort J. H. 
Published: November 2021

Mr Chairman, Ambassador Stevenson, Doctor Menzel, Regent McLaughlin, Representatives of our sister Scientific Unions, Ladies and Gentlemen:It is a pleasure to open the second General Assembly which the International Astronomical Union is holding in America. It is a special privilege to be able to do this in California, to which astronomy owes so much of its development in this century. We are deeply indebted to the Government of the United States and the National Academy of Sciences for inviting us to their country and in particular for providing the means to enable us to hold so complete a meeting at such a large distance from Europe. I thank President Kennedy and the Governor of California for their messages of welcome. That you, Ambassador Stevenson, have come to Berkeley especially for this occasion to welcome us, is a source of particular gratitude. You may be assured that we astronomers will do all we can to make our small contribution to international understanding as perfect as possible.
Does anthropogenic fragmentation selectively filter avian phylogenetic diversity in a critically endangered forest system?
Authors: EHLERS SMITH DAVID A. , WILLOWS-MUNRO SANDI , EHLERS SMITH YVETTE C. , DOWNS COLLEEN T. 
Published: November 2021

SummaryDocumenting phylogenetic diversity for conservation practice allows elucidation of ecosystem functioning and processes by highlighting the commonality and divergence of species’ functional traits within their evolutionary context. Conserving distinct evolutionary histories has intrinsic value, and the conservation of phylogenetically diverse communities is more likely to preserve distinct or relic evolutionary lineages. We explored the potential for anthropogenic forest fragmentation to act as a selective filter of avian phylogenetic diversity within the community of forest-dependent birds of the critically endangered Indian Ocean Coastal Belt Forest (IOCBF), South Africa. We conducted avian point count surveys during the austral breeding season, and calculated fragmentation metrics of forest structural complexity, patch size and isolation. We constructed a maximum likelihood phylogeny using the combined analysis of two mitochondrial genes and three nuclear markers and measured the influence of the fragmentation metrics on six measures of phylogenetic diversity. Our results indicated that the avian community was variously affected by anthropogenic forest fragmentation, with the different metrics of phylogenetic diversity responding with no definitive overall pattern. However, forest structural complexity emerged as an important metric explaining phylogenetic structuring. While the avian community’s phylogenetic diversity displayed resilience to anthropogenic fragmentation, previous research showed a reduction in functional diversity along the fragmentation gradient. Therefore, we recommend studies that especially aim to guide conservation management, incorporate both phylogenetic and functional diversity measures to sufficiently interrogate communities’ resilience to the threats under investigation.
Meaning and Anti-Meaning in Life and What Happens After We Die
Authors: Nyholm Sven 
Published: November 2021

AbstractThe absence of meaningfulness in life is meaninglessness. But what is the polar opposite of meaningfulness? In recent and ongoing work together with Stephen Campbell and Marcello di Paola respectively, I have explored what we dub ‘anti-meaning’: the negative counterpart of positive meaning in life. Here, I relate this idea of ‘anti-meaningful’ actions, activities, and projects to the topic of death, and in particular the deaths or suffering of those who will live after our own deaths. Connecting this idea of anti-meaning and what happens after our own deaths to recent work by Samuel Scheffler on what he calls ‘the collective afterlife’ and his four reasons to care about future generations, I argue that if we today make choices or have lifestyles that later lead to unnecessarily early deaths and otherwise avoidable suffering of people who will live after we have died, this robs our current choices and lifestyles of some of their meaning, perhaps even making them the opposite of meaningful in the long run.
Meaning in Lives Nearing Their End
Authors: Kamm F. M. 
Published: November 2021

AbstractIn this paper, I consider the idea of meaning in life as I believe it has arisen in some discussions of ageing and death. I critically examine and compare the views of Atul Gawande and Ezekiel Emanuel, connecting their views to the idea of meaning in life. I further consider the relation of meaning in life to both the dignity of the person and the reasonableness of continuing or not continuing to live. In considering these issues, I evaluate and draw on Bernard Williams’ distinction between categorical and conditional desires, Susan Wolf's work on meaning in life, and Jeremy Waldron's views on dignity in old age.
Variability and Controls on δ18O, d‐excess, and ∆′17O in Southern Peruvian Precipitation
Authors: Aron Phoebe G. , Poulsen Christopher J. , Fiorella Richard P. , Levin Naomi E. , Acosta Rene P. , Yanites Brian J. , Cassel Elizabeth J. 
Published: November 2021

AbstractThe isotopic composition of precipitation is used to trace water cycling and climate change, but interpretations of the environmental information recorded in central Andean precipitation isotope ratios are hindered by a lack of multi‐year records, poor spatial distribution of observations, and a predominant focus on Rayleigh distillation. To better understand isotopic variability in central Andean precipitation, we present a three‐year record of semimonthly δ18Op and δ2Hp values from 15 stations in southern Peru and triple oxygen isotope data, expressed as ∆′17Op, from 32 precipitation samples. Consistent with previous work, we find that elevation correlates negatively with δ18Op and that seasonal δ18Op variations are related to upstream rainout and local convection. Spatial δ18Op variations and atmospheric back trajectories show that both eastern‐ and western‐derived air masses bring precipitation to southern Peru. Seasonal d‐excessp cycles record moisture recycling and relative humidity at remote moisture sources, and both d‐excessp and ∆′17Op clearly differentiate evaporated and non‐evaporated samples. These results begin to establish the natural range of unevaporated ∆′17Op values in the central Andes and set the foundation for future paleoclimate and paleoaltimetry studies in the region. This study highlights the hydrologic understanding that comes from a combination of δ18Op, d‐excessp, and ∆′17Op data and helps identify the evaporation, recycling, and rainout processes that drive water cycling in the central Andes.
Continental and Sea Ice Iron Sources Fertilize the Southern Ocean in Synergy
Authors: Person Renaud , Vancoppenolle Martin , Aumont Olivier , Malsang Manon 
Published: November 2021

AbstractIron release from melting continental and sea ice is deemed important for phytoplankton, the growth of which is iron‐limited in the Southern Ocean. Both sources are generally considered separately, yet their effects on the biological carbon pump could interact. Using a global ocean‐sea‐ice‐biogeochemical model with a representation of both continental and sea ice iron sources, we find them to have an overall additive effect on phytoplankton activity, increasing carbon export by +13.9% of the Southern Ocean total, with continental ice contributing +4.5% and sea ice +8.0%. The +1.4% residual is due to a coupled fertilization effect: When the iron source from continental ice is activated, iron in sea ice increases by 16%, so does iron transport toward low production areas. Overall, this increases phytoplankton activity: Fertilization is more efficient where sea ice melts than at locations of initial iron release by continental ice.
Evaluation of Biogenic Organic Aerosols in the Amazon Rainforest Using WRF‐Chem With MOSAIC
Authors: Mao Jingying , Zhou Luxi , Wu Liqing , Chen Weihua , Wang Xuemei , Yu Pengfei 
Published: November 2021

AbstractBiogenic secondary organic aerosol (BSOA) accounts for 70%–80% of submicron aerosol over the Amazon rainforest. However, uncertainties with regard to the chemical formation pathway, mass budget, and radiative impact of BSOA in the region still remain high. To address the issue, we used a regional chemistry transport model (WRF‐Chem‐MOSAIC) to evaluate the budget of BSOA in the Amazon forest during the wet season (March) of 2014 when the air mass was clean from influences from anthropogenic and biomass burning emissions. We found that the default model underestimated the surface concentration of submicron organic aerosol (OA) by 57% at a ground measurement site (T3). We subsequently updated the WRF‐Chem‐MOSAIC model by including SOA formation from isoprene epoxydiols (IEPOX‐SOA) and SOA aging schemes. The updated model reproduced the observed submicron OA concentration well with an overestimation of only 2.5%. With the updated model, we will show that IEPOX‐SOA accounts for 23% of surface submicron OA averaged over the entire Amazon rainforest. The modeled surface SOA (smaller than 2.5 μm in diameter) concentration in the Amazon region was about a factor of 14 larger than the global mean. Finally, a sensitivity study was conducted which showed that convective plumes can remove more than 40% of submicron OA below 5 km in the Amazon region. Overall, our study highlights the importance of IEPOX chemistry as well as the convective removal processes in the global SOA budget.
An abiotic source of Archean hydrogen peroxide and oxygen that pre-dates oxygenic photosynthesis
Authors: He Hongping , Wu Xiao , Xian Haiyang , Zhu Jianxi , Yang Yiping , Lv Ying , Li Yiliang , Konhauser Kurt O. 
Published: November 2021

AbstractThe evolution of oxygenic photosynthesis is a pivotal event in Earth’s history because the O2 released fundamentally changed the planet’s redox state and facilitated the emergence of multicellular life. An intriguing hypothesis proposes that hydrogen peroxide (H2O2) once acted as the electron donor prior to the evolution of oxygenic photosynthesis, but its abundance during the Archean would have been limited. Here, we report a previously unrecognized abiotic pathway for Archean H2O2 production that involves the abrasion of quartz surfaces and the subsequent generation of surface-bound radicals that can efficiently oxidize H2O to H2O2 and O2. We propose that in turbulent subaqueous environments, such as rivers, estuaries and deltas, this process could have provided a sufficient H2O2 source that led to the generation of biogenic O2, creating an evolutionary impetus for the origin of oxygenic photosynthesis.
Fluids as primary carriers of sulphur and copper in magmatic assimilation
Authors: Virtanen Ville J. , Heinonen Jussi S. , Molnár Ferenc , Schmidt Max W. , Marxer Felix , Skyttä Pietari , Kueter Nico , Moslova Karina 
Published: November 2021

AbstractMagmas readily react with their wall-rocks forming metamorphic contact aureoles. Sulphur and possibly metal mobilization within these contact aureoles is essential in the formation of economic magmatic sulphide deposits. We performed heating and partial melting experiments on a black shale sample from the Paleoproterozoic Virginia Formation, which is the main source of sulphur for the world-class Cu-Ni sulphide deposits of the 1.1 Ga Duluth Complex, Minnesota. These experiments show that an autochthonous devolatilization fluid effectively mobilizes carbon, sulphur, and copper in the black shale within subsolidus conditions (≤ 700 °C). Further mobilization occurs when the black shale melts and droplets of Cu-rich sulphide melt and pyrrhotite form at ∼1000 °C. The sulphide droplets attach to bubbles of devolatilization fluid, which promotes buoyancy-driven transportation in silicate melt. Our study shows that devolatilization fluids can supply large proportions of sulphur and copper in mafic–ultramafic layered intrusion-hosted Cu-Ni sulphide deposits.
Direct evidence that twisted flux tube emergence creates solar active regions
Authors: MacTaggart D. , Prior C. , Raphaldini B. , Romano P. , Guglielmino S. L. 
Published: November 2021

AbstractThe magnetic nature of the formation of solar active regions lies at the heart of understanding solar activity and, in particular, solar eruptions. A widespread model, used in many theoretical studies, simulations and the interpretation of observations, is that the basic structure of an active region is created by the emergence of a large tube of pre-twisted magnetic field. Despite plausible reasons and the availability of various proxies suggesting the accuracy of this model, there has not yet been a methodology that can clearly and directly identify the emergence of large pre-twisted magnetic flux tubes. Here, we present a clear signature of the emergence of pre-twisted magnetic flux tubes by investigating a robust topological quantity, called magnetic winding, in solar observations. This quantity detects the emerging magnetic topology despite the significant deformation experienced by the emerging magnetic field. Magnetic winding complements existing measures, such as magnetic helicity, by providing distinct information about field line topology, thus allowing for the direct identification of emerging twisted magnetic flux tubes.
Cortical sensorimotor activity in the execution and suppression of discrete and rhythmic movements
Authors: Hervault Mario , Zanone Pier-Giorgio , Buisson Jean-Christophe , Huys Raoul 
Published: November 2021

AbstractAlthough the engagement of sensorimotor cortices in movement is well documented, the functional relevance of brain activity patterns remains ambiguous. Especially, the cortical engagement specific to the pre-, within-, and post-movement periods is poorly understood. The present study addressed this issue by examining sensorimotor EEG activity during the performance as well as STOP-signal cued suppression of movements pertaining to two distinct classes, namely, discrete vs. ongoing rhythmic movements. Our findings indicate that the lateralized readiness potential (LRP), which is classically used as a marker of pre-movement processing, indexes multiple pre- and in- movement-related brain dynamics in a movement-class dependent fashion. In- and post-movement event-related (de)synchronization (ERD/ERS) observed in the Mu (8–13 Hz) and Beta (15–30 Hz) frequency ranges were associated with estimated brain sources in both motor and somatosensory cortical areas. Notwithstanding, Beta ERS occurred earlier following cancelled than actually performed movements. In contrast, Mu power did not vary. Whereas Beta power may reflect the evaluation of the sensory predicted outcome, Mu power might engage in linking perception to action. Additionally, the rhythmic movement forced stop (only) showed a post-movement Mu/Beta rebound, which might reflect an active "clearing-out" of the motor plan and its feedback-based online control. Overall, the present study supports the notion that sensorimotor EEG modulations are key markers to investigate control or executive processes, here initiation and inhibition, which are exerted when performing distinct movement classes.
A novel aerial manipulator system compensation control based on ADRC and backstepping
Authors: Ma Le , Yan Yiming , Li Zhiwei , Liu Jie 
Published: November 2021

AbstractThis paper proposes a fully-actuated control method for a novel aerial manipulation system (AMS). A customized carbon frame structure supports the servo actuators, on which eight propellers group into pairs located. We present kinematics and dynamics modeling of the AMS based on Craig parameter method and recursive Newton–Euler equation, respectively. Then, an Active disturbance rejection control (ADRC)—Backstepping—Compensation controller is designed to control the exact position and orientation of the manipulator in the Cartesian space. Finally, the performance of the system is demonstrated through simulations and virtual experiments.
Combined effects of ARNI and SGLT2 inhibitors in diabetic patients with heart failure with reduced ejection fraction
Authors: Kim Hyue Mee , Hwang In-Chang , Choi Wonsuk , Yoon Yeonyee E. , Cho Goo-Yeong 
Published: November 2021

AbstractAngiotensin receptor-neprilysin inhibitor (ARNI) and sodium–glucose co-transporter-2 inhibitor (SGLT2i) have shown benefits in diabetic patients with heart failure with reduced ejection fraction (HFrEF). However, their combined effect has not been revealed. We retrospectively identified diabetic patients with HFrEF who were prescribed an ARNI and/or SGLT2i. The patients were divided into groups treated with both ARNI and SGLT2i (group 1), ARNI but not SGLT2i (group 2), SGLT2i but not ARNI (group 3), and neither ARNI nor SGLT2i (group 4). After propensity score-matching, the occurrence of hospitalization for heart failure (HHF), cardiovascular mortality, and changes in echocardiographic parameters were analyzed. Of the 206 matched patients, 92 (44.7%) had to undergo HHF and 43 (20.9%) died of cardiovascular causes during a median 27.6 months of follow-up. Patients in group 1 exhibited a lower risk of HHF and cardiovascular mortality compared to those in the other groups. Improvements in the left ventricular ejection fraction and E/e′ were more pronounced in group 1 than in groups 2, 3 and 4. These echocardiographic improvements were more prominent after the initiation of ARNI, compare to the initiation of SGLT2i. In diabetic patients with HFrEF, combination of ARNI and SGT2i showed significant improvement in cardiac function and prognosis. ARNI-SGLT2i combination therapy may improve the clinical course of HFrEF in diabetic patients.
Characterization of normal and cancer stem-like cell populations in murine lingual epithelial organoids using single-cell RNA sequencing
Authors: Johansson Erik , Ueno Hiroo 
Published: November 2021

AbstractThe advances in oral cancer research and therapies have not improved the prognosis of patients with tongue cancer. The poor treatment response of tongue cancer may be attributed to the presence of heterogeneous tumor cells exhibiting stem cell characteristics. Therefore, there is a need to develop effective molecular-targeted therapies based on the specific gene expression profiles of these cancer stem-like cell populations. In this study, the characteristics of normal and cancerous organoids, which are convenient tools for screening anti-cancer drugs, were analyzed comparatively. As organoids are generally generated by single progenitors, they enable the exclusion of normal cell contamination from the analyses. Single-cell RNA sequencing analysis revealed that p53 signaling activation and negative regulation of cell cycle were enriched characteristics in normal stem-like cells whereas hypoxia-related pathways, such as HIF-1 signaling and glycolysis, were upregulated in cancer stem-like cells. The findings of this study improved our understanding of the common features of heterogeneous cell populations with stem cell properties in tongue cancers, that are different from those of normal stem cell populations; this will enable the development of novel molecular-targeted therapies for tongue cancer.
Optimized production, Pb(II) adsorption and characterization of alkali modified hydrochar from sugarcane bagasse
Authors: Malool Mohamad Ebrahim , Keshavarz Moraveji Mostafa , Shayegan Jalal 
Published: November 2021

AbstractToday, sugarcane bagasse (SB) is used for bioethanol and biodiesel production, energy generation, and adsorbent synthesis. The goal of this project is to determine the optimized conditions for producing adsorbent from sugarcane bagasse using hydrothermal carbonization (HTC) and KOH activation. To optimize process parameters such as reaction temperature, residence time, ZnCl2/SB mixing ratios, and water/SB mixing ratios, response surface methodology was used. The results revealed that the optimum modified adsorption occurred at 180 °C, 11.5 h, a water to biomass ratio of (5:1), and a ZnCl2 to precursor ratio of (3.5:1). The physicochemical features of optimum activated hydrochar were investigated, as well as batch adsorption experiments. The pseudo-second-order kinetic model and the Langmuir isotherm model were found to fit the experimental results in batch adsorption studies [$${q}_{max}=90.1$$

q

max

=
90.1

(mg/g)]. Thermodynamic experiments further confirmed the spontaneous and exothermic adsorption mechanism.
Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
Authors: Kim Hosu , Jung Jaehoon , Cho Young-Seok , Choi Joon Young , Park Hyunju , Lee You-Bin , Kim Sun Wook , Chung Jae Hoon , Kim Tae Hyuk 
Published: November 2021

AbstractSerum thyrotropin (TSH) level after thyroid surgery affects the prognosis of differentiated thyroid cancer (DTC). However, the effects of preoperative serum TSH levels on the prognosis of DTC remain contradictory. In this study, to better understand the relationship between preoperative TSH levels and the prognosis of DTC, we performed pattern analysis of prognostic factors of DTC according to preoperative serum TSH levels. We retrospectively reviewed the clinical records of patients who were diagnosed and treated for DTC at the Samsung Medical Center, between 1994 and 2016. We reviewed preoperative serum TSH levels and performed a pattern analysis with prognostic risk factors for DTC. For pattern analysis, TSH was divided into 10 groups of equal fractions (TSH decile). We found a linear association between preoperative TSH levels and extra-thyroidal extension and lymph node metastasis. However, primary tumor size and initial distant metastasis showed a bimodal peak, which was similar to the pattern of overall and disease-specific death. We found that preoperative TSH range which showed the lowest mortality rate was about 0.8 to 1.59 mIU/L, which are slightly lower normal TSH levels. Although there was no linear trend, the primary tumor size, initial distant metastasis, and mortality of DTC were closely related with preoperative TSH decile and they showed a bimodal pattern. The results obtained in this study provide additional information for understanding the association between preoperative TSH levels and DTC prognosis.
Regulating the *OCCHO intermediate pathway towards highly selective photocatalytic CO2 reduction to CH3CHO over locally crystallized carbon nitride
Authors: Liu Qiong , Cheng Hui , Chen Tianxiang , Lo Tsz Woon Benedict , Xiang Zhangmin , Wang Fuxian 
Published: November 2021

Locally crystallized PCN is prone to form *OCCHO groups rather than *CH2O groups, regulating the endoergic C–C coupling step to a simultaneous exoergic reaction and changing the reaction pathway towards CH3CHO (selectivity of 98.3%) instead of HCHO.