bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies to improve postpartum glucose screening rates are needed
Authors: Farid Huma , Blake Rachel , Hacker Michele R. , Erlinger Adrienne L. , Modest Anna M. 
Published: May 2021

AbstractAimsWomen with gestational diabetes mellitus (GDM) require postpartum glucose screening, as they have a 70% lifetime risk of developing Type 2 diabetes mellitus. However, less than half complete postpartum screening.MethodsWe conducted a retrospective chart review of patients who delivered at our institution from 2001 to 2019. Inclusion criteria were patients with gestational diabetes who were at least 18 years old and had delivered an infant at >24 weeks of gestation. Our primary outcome was completion of postpartum gestational diabetes screening.ResultsThe majority of patients (62%) did not complete screening. After adjusted risk ratio analyses, the only variables that remained significantly associated with an increased likelihood of completing screening were Asian race and having prenatal care at one particular community health center, which served a predominantly Asian population.ConclusionsThis community health center protocol for scheduling patients with GDM that complied with recommendations for postpartum care, indicating that evidence‐based methods can improve maternal health.
The Similarity between Target and Nontarget Affects Different Processing Stages Depending on Stimulus Feature Dimensions: An ERP Study1
Authors: Fujii Yumiko , Morita Hiromi , Takeda Yuji 
Published: May 2021

AbstractPrevious studies have demonstrated that when target and nontarget objects are similar, comparing the representation of the currently viewed object and the target representation in memory requires more attentional resources, thus resulting in less efficient discrimination processes. An important factor determining this effect is how many features are shared between the target and nontarget objects. The present study examined whether the effect of the target‐nontarget similarity on attentional processes depends mainly on the individual feature representations or on the feature‐integrated representation. A visual three‐category oddball task that required the detection of a target defined by a combination of color, shape, and motion was conducted. Results showed an increase in amplitudes of the earlier late positive complex (LPC) for the deviant stimuli when they shared the same color as the target. This increase lasted until the later LPC, when they also shared the same shape. Findings suggest that the target‐nontarget similarity in each feature dimension determined the amount of required attentional resources on later attentional processes in a serial and hierarchical manner.
The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration
Authors: Taira Yuki , Omote Yoshio , Kawahara Yuko , Nomura Emi , Sasaki Ryo , Matsumoto Namiko , Matsuoka Chika , Takemoto Mami , Morihara Ryuta , Hishikawa Nozomi , Yamashita Toru , Abe Koji 
Published: May 2021

AbstractWe report on a 35‐year‐old man who had gender dysphoria following unilateral ovariectomy and then received continuous testosterone injection for nine years, inducing chronic inflammatory demyelinating polyneuropathy (CIDP). He developed recurrent muscle weakness and numbness in the extremities and displayed demyelinating neuropathy, detected by nerve conduction studies and a sural nerve biopsy. Repeated intravenous immunoglobulin (IVIg) therapy and the administration of oral prednisolone improved symptoms and inhibited their recurrence. A relatively high level of serum testosterone as a genetic female might have caused the neurotoxicity of the peripheral nerve, leading to CIDP.
What About the Rest of the Pie? A Dynamic Compositional Approach to Modeling Inequality
Authors: Kagalwala Ali , Philips Andrew Q. , Whitten Guy D. 
Published: May 2021

ObjectiveTo demonstrate how a novel method enhances our understanding of determinants of inequality.MethodsWe take advantage of recent advances in dynamic models of compositional dependent variables to simultaneously study tradeoffs across multiple slices of the composition of income in the United States between 1947 and 2014.ResultsOur analyses demonstrate the utility of dynamic compositional models of income shares. Factors that increase the income share of the top income group often also increase the income share of the second income group and decrease the shares of lower groups at different rates. Polarization and marginal tax rates have large effects on relative income shares, while returns to labor, returns to capital, and partisan control of Congress have smaller, but statistically significant effects.ConclusionOur suggested approach allows researchers to effectively explore interesting variation across multiple income groups in response to changes in determinants of inequality.
CALIBRATION AND VALIDATION OF SWMM MODEL IN A SUB CATCHMENT IN ELDORET TOWN, KENYA
Authors: Abraham Metto Rotich , Clement Kiprotich Kiptum , Emmanuel Chessum Kipkorir 
Published: May 2021

Flooding in Eldoret town has been occurring during heavy downpours resulting in loss of property, live and interruption of transportation systems. This study aimed at determining the catchment characteristics in Eldoret town for the calibration and validation of SWMM5 model. This model was developed by US Environmental Protection Agency. The model has been evolving from Version 1 in 1971 to Version 5 of 2005 called SWMM5. It can simulate runoff quantity in any given catchment. Rainfall was measured using rain gauge while discharge was measured using current meter. Digital Elevation Model of the study area was also obtained. The results showed that the catchment drained an area of approximately 696.5 hectares with a total of 23 sub catchments. The average slope was found to be 2.57% and the mean average imperviousness was 25.72%. The drain base flow was found to be 0.002 m3/s. However, during prolonged rainfall, the discharge increased up to 32.4 m3/s. The maximum rainfall observed during the study period was 32.4 mm which resulted in the maximum average discharge of 0.131m3/s and resulted in overflow in the drain. Calibrated model had N-Imperv of 0.45, Dstore-Imperv of 2.5 and Dstore-Perv of 8. ISE values of 1.9 and 1.4 were observed for calibration and validation, respectively. NSE values of 0.97 and 0.99 were observed for calibration and validation, respectively. This meant that model excellently simulated rainfall-discharge relationship in the study area and can be used for final design by the Eldoret town engineers. Future study is required to calibrate the model based on more measurements of rainfall and their discharges in the catchment.
Dose–Response Relationship Between Velocity Loss During Resistance Training and Changes in the Squat Force–Velocity Relationship
Authors: Alcazar Julian , Cornejo-Daza Pedro J. , Sánchez-Valdepeñas Juan , Alegre Luis M. , Pareja-Blanco Fernando 
Published: May 2021

Purpose: This study aimed to compare the adaptations provoked by various velocity loss (VL) thresholds used in resistance training on the squat force–velocity (F–V) relationship. Methods: Sixty-four resistance-trained young men were randomly assigned to one of four 8-week resistance training programs (all 70%–85% 1-repetition maximum) using different VL thresholds (VL0 = 0%, VL10 = 10%, VL20 = 20%, and VL40 = 40%) in the squat exercise. The F–V relationship was assessed under unloaded and loaded conditions in squat. Linear and hyperbolic (Hill) F–V equations were used to calculate force at zero velocity (F0), velocity at zero force (V0), maximum muscle power (Pmax), and force produced at mean velocities ranging from 0.0 to 2.0 m·s−1. Changes in parameters derived from the F–V relationship were compared among groups using linear mixed models. Results: Linear equations showed increases in F0 (120.7 N [89.4 to 152.1]) and Pmax (76.2 W [45.3 to 107.2]) and no changes in V0 (−0.02 m·s−1 [−0.11 to 0.06]) regardless of VL. Hyperbolic equations depicted increases in F0 (120.7 N [89.4 to 152.1]), V0 (1.13 m·s−1 [0.78 to 1.48]), and Pmax (198.5 W [160.5 to 236.6]) with changes in V0 being greater in VL0 and VL10 versus VL40 (both P < .001). All groups similarly improved force at 0.0 to 2.0 m·s−1 (all P < .001), although in general, effect sizes were greater in VL10 and VL20 versus VL0 and VL40 at velocities ≤0.5 m·s−1. Conclusions: All groups improved linear and hyperbolic F0 and Pmax and hyperbolic V0 (except VL40). The dose–response relationship exhibited an inverted U-shape pattern at velocities ≤0.5 m·s−1 with VL10 and VL20 showing the greatest standardized changes.
Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis
Authors: Shipley Lara , Mistry Aarti , Sharkey Don 
Published: May 2021

ObjectiveTherapeutic hypothermia (TH) for neonatal hypoxic-ischaemic encephalopathy (HIE), delivered mainly in tertiary cooling centres (CCs), reduces mortality and neurodisability. It is unknown if birth in a non-cooling centre (non-CC), without active TH, impacts short-term outcomes.DesignRetrospective cohort study using National Neonatal Research Database and propensity score-matching.SettingUK neonatal units.PatientsInfants ≥36 weeks gestational age with moderate or severe HIE admitted 2011–2016.InterventionsBirth in non-CC compared with CC.Main outcome measuresPrimary outcome was survival to discharge without recorded seizures. Secondary outcomes were recorded seizures, mortality and temperature on arrival at CCs following transfer.Results5059 infants were included with 2364 (46.7%) born in non-CCs. Birth in a CC was associated with improved survival without seizures (35.1% vs 31.8%; OR 1.15, 95% CI 1.02 to 1.31; p=0.02), fewer seizures (60.7% vs 64.6%; OR 0.84, 95% CI 0.75 to 0.95, p=0.007) and similar mortality (15.8% vs 14.4%; OR 1.11, 95% CI 0.93 to 1.31, p=0.20) compared with birth in a non-CC. Matched infants from level 2 centres only had similar results, and birth in CCs was associated with greater seizure-free survival compared with non-CCs. Following transfer from a non-CC to a CC (n=2027), 1362 (67.1%) infants arrived with a recorded optimal therapeutic temperature but only 259 (12.7%) of these arrived within 6 hours of birth.ConclusionsAlmost half of UK infants with HIE were born in a non-CC, which was associated with suboptimal hypothermic treatment and reduced seizure-free survival. Provision of active TH in non-CC hospitals prior to upward transfer warrants consideration.
Poor Masticatory Capacity and Blood Biomarkers of Elevated Cardiovascular Disease Risk in the Community: The Paris Prospective Study III
Authors: Chatzopoulou Eirini , Rangé Hélène , Deraz Omar , Boutouyrie Pierre , Perier Marie-Cécile , Guibout Catherine , Thomas Frédérique , Andrieu Muriel , Bailly Karine , Vedie Benoît , Danchin Nicolas , Jouven Xavier , Bouchard Philippe , Empana Jean-Philippe 
Published: May 2021

Objective:
The mechanisms underlying the association between low number of masticatory units and cardiovascular disease remain unclear. Under a nutritional framework, we hypothesized that poor masticatory capacity could represent an early sign of elevated cardiovascular disease risk as evaluated by circulating markers of systemic inflammation and cardiomyocyte stress or damage.

Approach and Results:

In this cross-sectional analysis of the Paris Prospective Study III, a community-based observational study, 4837 adults aged 50 to 75 without cardiovascular disease history underwent a full-mouth clinical examination and plasma NTproBNP (N-terminal natriuretic propeptide), hs-CRP (high-sensitivity C-reactive protein), IL-6 (interleukin-6), hs-TNI (high-sensitivity troponin I) were measured using highly sensitive technics. Poor masticatory capacity was defined as <5 functional masticatory units, that is, pairs of opposing natural or prosthetically replaced posterior teeth. In linear regression analysis accounting for sociodemographic factors, cardiovascular disease risk factors, gingival inflammation, and body mass index, poor masticatory capacity was significantly associated with lower levels of NTproBNP (β=−0.11,
P
=0.045). The significant association between poor masticatory capacity and higher IL-6 in multivariable analysis was confounded by body mass index. There was no association between functional masticatory units and hs-TNI even in unadjusted analysis.

Conclusions:
The present findings support a nutritional pathway whereby diet alterations and the resulting abdominal obesity associated with poor masticatory capacity may contribute to the higher level of IL-6 and to the lower level of NTproBNP, respectively.
al-Nuzha al-Sāsāniyya by Shīrīn Maghribī (d. 810/1408)
Authors: Martini Giovanni Maria 
Published: May 2021

Abstract
This article presents for the first time the treatise al-Nuzha al-Sāsāniyya by the Tabrizi Sufi scholar and poet Muḥammad Shīrīn Maghribī (d. 810/1408), hitherto considered lost. The analysis of this Persian cosmology work, the rich graphic materials it contains, and its relationship with some of Ibn al-ʿArabī’s (d. 638/1240) most important cosmological texts including the treatise ʿUqlat al-mustawfiz and Chapter 371 of al-Futūḥāt al-Makkiyya, offers a unique opportunity for shedding new light on Maghribī as an eminent member of the so-called ‘School of Ibn al-ʿArabī’ and on his intellectual activity as a teacher and interpreter of the works and ideas of the Shaykh al-Akbar. At the same time, it explores the use of visual elements, and more specifically of diagrams, in the Sufi literature of the period, and their potential value for codicological and philological purposes.
On Tidal Modulation of the Evolution of Internal Solitary-Like Waves Passing Through a Critical Point
Authors: Bai Xiaolin , Lamb Kevin G. , Hu Jianyu , Liu Zhiyu 
Published: May 2021

AbstractInternal solitary-like waves (ISWs) evolve considerably when passing through a critical point separating the deep water where ISWs are waves of depression and shallower water where they are waves of elevation. The location of the critical point is determined by the background current and stratification. In this study, we investigate the influence of tidal currents on the cross-shelf movement of the critical point and elucidate the underlying processes via fully nonlinear numerical simulations. Our simulations reveal phase-locked tidal variations of the critical point, which are mainly attributed to stratification fluctuations that are modulated by the combined effects of cross-shelf barotropic tidal currents and locally generated baroclinic tides. The barotropic tidal currents drive isopycnal displacements as they flow over the slope, and as this occurs baroclinic tides are generated, modulating the stratification and inducing sheared currents. This results in a cross-shelf movement of the critical point, which moves onshore (offshore) when the pycnocline is elevated (depressed) by the flood (ebb) tide. Our idealized numerical simulations for the study region in the South China Sea suggest that the cross-shelf movement of the critical point reaches to O(10) km within a tidal cycle. This distance depends on the strength of tidal currents, stratification, and bathymetry. Because of tidal currents, ISWs of depression may undergo a complex evolution even in a stratification with a shallow pycnocline. For the stratification with a deep pycnocline, the critical point may be at a location deep enough so that its tidal movement becomes insignificant.
Loss of a 7q gene,CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms
Authors: Imgruet Molly K. , Lutze Julian , An Ningfei , Hu Bonnie , Khan Saira , Kurkewich Jeffrey , Martinez Tanner C. , Wolfgeher Donald , Gurbuxani Sandeep K. , Kron Stephen J. , McNerney Megan E. 
Published: May 2021

AbstractTherapy-related myeloid neoplasms (t-MNs) are high-risk late effects with poorly understood pathogenesis in cancer survivors. It has been postulated that, in some cases, hematopoietic stem and progenitor cells (HSPCs) harboring mutations are selected for by cytotoxic exposures and transform. Here, we evaluate this model in the context of deficiency of CUX1, a transcription factor encoded on chromosome 7q and deleted in half of t-MN cases. We report that CUX1 has a critical early role in the DNA repair process in HSPCs. Mechanistically, CUX1 recruits the histone methyltransferase EHMT2 to DNA breaks to promote downstream H3K9 and H3K27 methylation, phosphorylated ATM retention, subsequent γH2AX focus formation and propagation, and, ultimately, 53BP1 recruitment. Despite significant unrepaired DNA damage sustained in CUX1-deficient murine HSPCs after cytotoxic exposures, they continue to proliferate and expand, mimicking clonal hematopoiesis in patients postchemotherapy. As a consequence, preexisting CUX1 deficiency predisposes mice to highly penetrant and rapidly fatal therapy-related erythroleukemias. These findings establish the importance of epigenetic regulation of HSPC DNA repair and position CUX1 as a gatekeeper in myeloid transformation.
Albino seedling lethality 4; Chloroplast 30S Ribosomal Protein S1 is Required for Chloroplast Ribosome Biogenesis and Early Chloroplast Development in Rice
Authors: Zhou Kunneng , Zhang Caijuan , Xia Jiafa , Yun Peng , Wang Yuanlei , Ma Tingchen , Li Zefu 
Published: May 2021

AbstractBackgroundRibosomes responsible for transcription and translation of plastid-encoded proteins in chloroplasts are essential for chloroplast development and plant growth. Although most ribosomal proteins in plastids have been identified, the molecular mechanisms regulating chloroplast biogenesis remain to be investigated.ResultsHere, we identified albinic seedling mutantalbino seedling lethality 4(asl4) caused by disruption of 30S ribosomal protein S1 that is targeted to the chloroplast. The mutant was defective in early chloroplast development and chlorophyll (Chl) biosynthesis. A 2855-bp deletion in theASL4allele was verified as responsible for the mutant phenotype by complementation tests. Expression analysis revealed that theASL4allele was highly expressed in leaf 4 sections and newly expanded leaves during early leaf development. Expression levels were increased by exposure to light following darkness. Some genes involved in chloroplast biogenesis were up-regulated and others down-regulated inasl4mutant tissues compared to wild type. Plastid-encoded plastid RNA polymerase (PEP)-dependent photosynthesis genes and nuclear-encoded phage-type RNA polymerase (NEP)-dependent housekeeping genes were separately down-regulated and up-regulated, suggesting that plastid transcription was impaired in the mutant. Transcriptome and western blot analyses showed that levels of most plastid-encoded genes and proteins were reduced in the mutant. The decreased contents of chloroplast rRNAs and ribosomal proteins indicated that chloroplast ribosome biogenesis was impaired in theasl4mutant.ConclusionsRiceASL4encodes 30S ribosomal protein S1, which is targeted to the chloroplast.ASL4is essential for chloroplast ribosome biogenesis and early chloroplast development. These data will facilitate efforts to further elucidate the molecular mechanism of chloroplast biogenesis.
RNA-Seq analysis of blood meal induced gene-expression changes in Aedes aegypti ovaries
Authors: Nag Dilip K. , Dieme Constentin , Lapierre Pascal , Lasek-Nesselquist Erica , Kramer Laura D. 
Published: May 2021

Abstract
Background
Transmission of pathogens by vector mosquitoes is intrinsically linked with mosquito’s reproductive strategy because anautogenous mosquitoes require vertebrate blood to develop a batch of eggs. Each cycle of egg maturation is tightly linked with the intake of a fresh blood meal for most species. Mosquitoes that acquire pathogens during the first blood feeding can transmit the pathogens to susceptible hosts during subsequent blood feeding and also vertically to the next generation via infected eggs. Large-scale gene-expression changes occur following each blood meal in various tissues, including ovaries. Here we analyzed mosquito ovary transcriptome following a blood meal at three different time points to investigate blood-meal induced changes in gene expression in mosquito ovaries.

Results
We collected ovaries from Aedes aegypti that received a sugar meal or a blood meal on days 3, 10 and 20 post blood meal for transcriptome analysis. Over 4000 genes responded differentially following ingestion of a blood meal on day 3, and 660 and 780 genes on days 10 and 20, respectively. Proteins encoded by differentially expressed genes (DEGs) on day 3 include odorant binding proteins (OBPs), defense-specific proteins, and cytochrome P450 detoxification enzymes. In addition, we identified 580 long non-coding RNAs that are differentially expressed at three time points. Gene ontology analysis indicated that genes involved in peptidase activity, oxidoreductase activity, extracellular space, and hydrolase activity, among others were enriched on day 3. Although most of the DEGs returned to the nonsignificant level compared to the sugar-fed mosquito ovaries following oviposition on days 10 and 20, there remained differences in the gene expression pattern in sugar-fed and blood-fed mosquitoes.

Conclusions
Enrichment of OBPs following blood meal ingestion suggests that these genes may have other functions besides being part of the olfactory system. The enrichment of immune-specific genes and cytochrome P450 genes indicates that ovaries become well prepared to protect their germ line from any pathogens that may accompany the blood meal or from environmental contamination during oviposition, and to deal with the detrimental effects of toxic metabolites.
Aseptic meningitis as the initial presentation of Leptospira borgpetersenii serovar Tarassovi: two case reports and a literature review
Authors: Bandara A. G. N. M. K. , Kalaivarny G. , Perera Nilanka , Indrakumar J. 
Published: May 2021

Abstract
Background
Leptospirosis is a zoonotic illness caused by pathogenic spirochetes of the genus Leptospira. The disease spectrum ranges from a mild influenza-like presentation to a more serious Weil’s syndrome. Leptospirosis rarely presents as a primary neurological syndrome. We report two cases of Leptospira borgpetersenii serovar Tarasssovi presenting as aseptic meningitis in Sri Lanka.

Case presentation
We describe case reports of two patients presenting as symptomatic aseptic meningitis due to neuroleptospirosis. Both patients had significant neurological involvement at presentation in the absence of common clinical features of leptospirosis. These patients were initially managed as bacterial or viral meningitis and leptospirosis was suspected due to a history of exposure to contaminated water. Subsequently, they were diagnosed to have neuroleptospirosis by positive Leptospira serology and both patients gained full recovery.

Conclusion
Our report highlights the importance of considering leptospirosis as a differential diagnosis in patients with aseptic meningitis in endemic settings. Obtaining a detailed occupational and recreational history is helpful in diagnosing neuroleptospirosis promptly. We report the association of Leptospira borgpetersenii serovar (sv.) Tarassovi (strain bakeri) in causing aseptic meningitis, which has not been reported to the best of our knowledge.