bluuebunny/crossref_metadata_2025_split huggingface dataset:
Footprints in Time: Physical Activity Levels and Sociodemographic and Movement-Related Associations Within the Longitudinal Study of Indigenous Children
Authors: Macniven Rona , Wilson Rachel , Olds Tim , Evans John 
Published: February 2021

Background: Emerging evidence suggests that Indigenous children have higher physical activity levels that non-Indigenous children, yet little is known of the factors that influence these levels or how they may be optimized. This study examines correlates of achieving ≥1 hour/day of physical activity among Indigenous Australian children aged 8–13 years. Methods: Data were collected through parental self-report in the Longitudinal Study of Indigenous Children. Proportions of children achieving ≥1 hour/day physical activity, approximating the Australian aerobic physical activity recommendations, were calculated, and associations with sociodemographic, family composition, and movement-related factors were quantified using multiple logistic regression analyses. Results: Half of the 1233 children achieved ≥1 hour/day physical activity. Children from families with low parental education and unemployment, remote residence, low socioeconomic status, and without a father in the household were more likely to meet the recommendations. Achieving ≥1 hour/day of physical activity was also associated with low levels of playing electronic games and total screen time. Conclusions: Sociodemographic correlates of physical activity among Indigenous Australian children run counter to those typically found in non-Indigenous Australian children. Further longitudinal examination of the predictors of these associations would provide a greater understanding of Indigenous physical activity determinants, to inform strategies to facilitate participation.
Antibiotic exposure during pregnancy and childhood asthma: a national birth cohort study investigating timing of exposure and mode of delivery
Authors: Uldbjerg Cecilie Skaarup , Miller Jessica E , Burgner David , Pedersen Lars Henning , Bech Bodil Hammer 
Published: February 2021

ObjectiveTo investigate whether antibiotic exposure during pregnancy was associated with childhood asthma and if this relationship was conditional on timing of exposure and mode of delivery.DesignA cohort study using multivariable logistic regression models adjusting for a priori defined confounders. Pregnant women were recruited from 1996 to 2002.SettingThe Danish National Birth Cohort.PatientsOf the 96 832 children in the cohort, 32 651 children were included in the study population.Main outcome measureParent-reported childhood asthma at 11 years.ResultsA total of 5522 (17%) children were born to mothers exposed to antibiotics during pregnancy. In adjusted analyses, children born to exposed mothers had higher odds of asthma (OR 1.14, 95% CI 1.05 to 1.24). There was no association with antibiotic exposure in the first trimester (OR 1.02, 95% CI 0.83 to 1.26), but higher odds were observed for antibiotic exposure in the second to third trimester (OR 1.17, 95% CI 1.06 to 1.28), compared with unexposed children. The overall association between antibiotics during pregnancy and childhood asthma was only observed in vaginally born children (OR 1.17, 95% CI 1.07 to 1.28) but not in caesarean section born children (planned caesarean section: OR 0.95, 95% CI 0.66 to 1.37; caesarean emergency: OR 0.96, 95% CI 0.73 to 1.28). In exposed vaginally born children, the odds for childhood asthma requiring treatment during the preceding year were 34% higher (OR 1.34, 95% CI 1.21 to 1.49), compared with unexposed vaginally born children.ConclusionsAntibiotic exposure in mid-to-late pregnancy is associated with higher odds of childhood asthma in vaginally born children. Mode of delivery may modify the association.
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Authors: Sun Xiaoting , He Xingkang , Zhang Yin , Hosaka Kayoko , Andersson Patrik , Wu Jing , Wu Jieyu , Jing Xu , Du Qiqiao , Hui Xiaoli , Ding Bo , Guo Ziheng , Hong An , Liu Xuan , Wang Yan , Ji Qing , Beyaert Rudi , Yang Yunlong , Li Qi , Cao Yihai 
Published: February 2021

ObjectivePancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy.DesignTwo unselected cohorts of 154 and 20 patients with PDAC were subjected to correlation between interleukin (IL)-33 and CXCL3 levels and survivals. Unbiased expression profiling, and genetic and pharmacological gain-of-function and loss-of-function approaches were employed to identify molecular signalling in tumour-associated macrophages (TAMs) and myofibroblastic cancer-associated fibroblasts (myoCAFs). The role of the IL-33–ST2–CXCL3–CXCR2 axis in PDAC metastasis was evaluated in three clinically relevant mouse PDAC models.ResultsIL-33 was specifically elevated in human PDACs and positively correlated with tumour inflammation in human patients with PDAC. CXCL3 was highly upregulated in IL-33-stimulated macrophages that were the primary source of CXCL3. CXCL3 was correlated with poor survival in human patients with PDAC. Mechanistically, activation of the IL-33–ST2–MYC pathway attributed to high CXCL3 production. The highest level of CXCL3 was found in PDAC relative to other cancer types and its receptor CXCR2 was almost exclusively expressed in CAFs. Activation of CXCR2 by CXCL3 induced a CAF-to-myoCAF transition and α-smooth muscle actin (α-SMA) was uniquely upregulated by the CXCL3–CXCR2 signalling. Type III collagen was identified as the CXCL3–CXCR2-targeted adhesive molecule responsible for myoCAF-driven PDAC metastasis.ConclusionsOur work provides novel mechanistic insights into understanding PDAC metastasis by the TAM-CAF interaction and targeting each of these signalling components would provide an attractive and new paradigm for treating pancreatic cancer.
Adoption of focused ultrasound thalamotomy for essential tremor: why so much fuss about FUS?
Authors: Iorio-Morin Christian , Hodaie Mojgan , Lozano Andres M 
Published: February 2021

BackgroundFocused ultrasound (FUS) was approved as a new treatment modality for essential tremor (ET) in 2016. The goal of this study was to quantify FUS adoption for ET and understand its drivers.MethodsThe adoption of the various surgical options for ET was estimated using three measures: the number of presentations on the various surgical treatments for ET at specialised international meetings, the number of original papers published as identified by literature searches and the number of thalamotomy procedures performed worldwide for ET as provided by device manufacturers’ registries.ResultsFirst, we found that the number of presentations related to lesioning procedures is increasing relative to deep brain stimulation (DBS) at international meetings. Second, there are already more publications on FUS (93) than stereotactic radiosurgery (SRS) (68) or radiofrequency (43) for ET, although they still lag behind DBS papers (750). Third, the number of annual FUS thalamotomies performed for ET (n>1200 in 2019) in 44 centres has surpassed the annual procedures across 342 Gamma Knife units (n<400, 2018) but is yet to reach the number of DBS cases for ET estimated at over 2400/year.ConclusionFUS is being rapidly adopted for the treatment of ET. We hypothesise that its perceived minimally invasive nature coupled with the ability to perform intraoperative clinical assessments, its immediate effects and active marketing efforts are contributing factors. As lesioning modalities for the treatment of ET are reappraised, the superior popularity of FUS over SRS appears to arise for reasons other than differences in clinical outcomes.
Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes
Authors: Murley Alexander G , Rouse Matthew A , Coyle-Gilchrist Ian T S , Jones P Simon , Li Win , Wiggins Julie , Lansdall Claire , Vázquez Rodríguez Patricia , Wilcox Alicia , Patterson Karalyn , Rowe James B 
Published: February 2021

ObjectiveTo test the hypothesis that in syndromes associated with frontotemporal lobar degeneration, behavioural impairment predicts loss of functional independence and motor clinical features predict mortality, irrespective of diagnostic group.MethodsWe used a transdiagnostic approach to survival in an epidemiological cohort in the UK, testing the association between clinical features, independence and survival in patients with clinical diagnoses of behavioural variant frontotemporal dementia (bvFTD n=64), non-fluent variant primary progressive aphasia (nfvPPA n=36), semantic variant primary progressive aphasia (svPPA n=25), progressive supranuclear palsy (PSP n=101) and corticobasal syndrome (CBS n=68). A principal components analysis identified six dimensions of clinical features. Using Cox proportional hazards and logistic regression, we identified the association between each of these dimensions and both functionally independent survival (time from clinical assessment to care home admission) and absolute survival (time to death). Analyses adjusted for the covariates of age, gender and diagnostic group. Secondary analysis excluded specific diagnostic groups.ResultsBehavioural disturbance, including impulsivity and apathy, was associated with reduced functionally independent survival (OR 2.46, p<0.001), even if patients with bvFTD were removed from the analysis. Motor impairments were associated with reduced absolute survival, even if patients with PSP and CBS were removed from the analysis.ConclusionOur results can assist individualised prognostication and planning of disease-modifying trials, and they support a transdiagnostic approach to symptomatic treatment trials in patients with clinical syndromes associated with frontotemporal lobar degeneration.
Quality of life in isolated dystonia: non-motor manifestations matter
Authors: Junker Johanna , Berman Brian D , Hall James , Wahba Deena W , Brandt Valerie , Perlmutter Joel S , Jankovic Joseph , Malaty Irene A , Wagle Shukla Aparna , Reich Stephen G , Espay Alberto J , Duque Kevin R , Patel Neepa , Roze Emmanuel , Vidailhet Marie , Jinnah H.A. , Brüggemann Norbert 
Published: February 2021

ObjectiveTo evaluate the relationship between health-related quality of life (HR-QoL) and both physical and psychiatric factors in a large, international, multicentre cohort of patients with isolated dystonia, the Dystonia Coalition.MethodsNatural history data from 603 patients with isolated dystonia (median age 57 years (IQR: 48 to 64 years), 67.0% women) were prospectively acquired and analysed. HR-QoL (RAND 36-Item Health Survey), severity of depressive symptoms, generalised anxiety (Hospital Anxiety and Depression Scale) and social anxiety (Liebowitz Social Anxiety Scale) were assessed. Dystonia severity (Burke-Fahn-Marsden Dystonia Rating Scale) and dystonic tremor were examined. Statistical predictors of HR-QoL were calculated using saturated path analysis.ResultsReduced HR-QoL was strongly associated with the degree of depressive symptoms and generalised and social anxiety (8/8 RAND 36 subscales, p≤0.001). Increased dystonia severity was associated with worse physical functioning, physical and emotional role functioning and social functioning (all p≤0.001). The presence of tremor correlated with worse physical functioning and pain (all p≤0.006). Younger age was associated with reduced emotional well-being and vitality (all p≤0.006). There were no HR-QoL differences between sexes.ConclusionHR-QoL in isolated dystonia is strongly associated with psychiatric and physical features. While current standard of care focus on motor aspects of dystonia, comprehensive care should address both physical and mental aspects of health.
Clinical spectrum of high-titre GAD65 antibodies
Authors: Budhram Adrian , Sechi Elia , Flanagan Eoin P , Dubey Divyanshu , Zekeridou Anastasia , Shah Shailee S , Gadoth Avi , Naddaf Elie , McKeon Andrew , Pittock Sean J , Zalewski Nicholas L 
Published: February 2021

ObjectiveTo determine clinical manifestations, immunotherapy responsiveness and outcomes of glutamic acid decarboxylase-65 (GAD65) neurological autoimmunity.MethodsWe identified 323 Mayo Clinic patients with high-titre (>20 nmol/L in serum) GAD65 antibodies out of 380 514 submitted anti-GAD65 samples (2003–2018). Patients classified as having GAD65 neurological autoimmunity after chart review were analysed to determine disease manifestations, immunotherapy responsiveness and predictors of poor outcome (modified Rankin score >2).ResultsOn review, 108 patients were classified as not having GAD65 neurological autoimmunity and 3 patients had no more likely alternative diagnoses but atypical presentations (hyperkinetic movement disorders). Of remaining 212 patients with GAD65 neurological autoimmunity, median age at symptom onset was 46 years (range: 5–83 years); 163/212 (77%) were female. Stiff-person spectrum disorders (SPSD) (N=71), cerebellar ataxia (N=55), epilepsy (N=35) and limbic encephalitis (N=7) could occur either in isolation or as part of an overlap syndrome (N=44), and were designated core manifestations. Cognitive impairment (N=38), myelopathy (N=23) and brainstem dysfunction (N=22) were only reported as co-occurring phenomena, and were designated secondary manifestations. Sustained response to immunotherapy ranged from 5/20 (25%) in epilepsy to 32/44 (73%) in SPSD (p=0.002). Complete immunotherapy response occurred in 2/142 (1%). Cerebellar ataxia and serum GAD65 antibody titre >500 nmol/L predicted poor outcome.InterpretationHigh-titre GAD65 antibodies were suggestive of, but not pathognomonic for GAD65 neurological autoimmunity, which has discrete core and secondary manifestations. SPSD was most likely to respond to immunotherapy, while epilepsy was least immunotherapy responsive. Complete immunotherapy response was rare. Serum GAD65 antibody titre >500 nmol/L and cerebellar ataxia predicted poor outcome.
Efficacy of belimumab in two serologically distinct high disease activity subgroups of patients with systemic lupus erythematosus: post-hoc analysis of data from the phase III programme
Authors: Maslen Toni , Bruce Ian N , D'Cruz David , Ianosev Mihaela , Bass Damon L , Wilkinson Christel , Roth David A 
Published: February 2021

ObjectiveTo assess the appropriateness of expanded serological activity eligibility criteria for belimumab use in the UK systemic lupus erythematosus (SLE) population (and possibly other countries), which includes patients with either anti-double-stranded DNA (anti-dsDNA) positivityorhypocomplementaemia rather than both criteria.MethodsThis post-hoc analysis used data from three randomised, double-blind, placebo-controlled phase III belimumab trials: BLISS-52 (BEL110752;NCT00424476), BLISS-76 (BEL110751;NCT00410384) and BLISS-SC (BEL112341;NCT01484496). Patients with SLE were stratified by high disease activity (HDA): HDA1, Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) score ≥10, low complementandpositive anti-dsDNA; and HDA2, SELENA-SLEDAI ≥10 and either low complementorpositive anti-dsDNA.ResultsThis analysis included 660 HDA1 patients (n=396 on intravenous treatment; n=264 on subcutaneous treatment) and 969 HDA2 patients (n=532 on intravenous treatment; n=437 on subcutaneous treatment). Significant improvements were observed at week 52 with belimumab versus placebo, irrespective of subgroups or drug formulations, in SLE Responder Index (SRI) 4 response (OR (95% CI): HDA1 intravenous 2.7 (1.8 to 4.1); HDA2 intravenous 2.3 (1.61 to 3.26); HDA1 subcutaneous 2.2 (1.22 to 3.85); HDA2 subcutaneous 1.8 (1.17 to 2.74)); proportion of patients achieving ≥4-point reduction in SELENA-SLEDAI score (OR (95% CI): HDA1 intravenous 2.6 (1.7 to 3.9); HDA2 intravenous 2.1 (1.49 to 3.03); HDA1 subcutaneous 2.3 (1.30 to 4.14); HDA2 subcutaneous 1.9 (1.21 to 2.84)); patients with no worsening in Physician Global Assessment (OR (95% CI): HDA1 intravenous 2.0 (1.3 to 3.1); HDA2 intravenous 1.7 (1.17 to 2.45); HDA1 subcutaneous 2.3 (1.18 to 4.40); HDA2 subcutaneous 1.8 (1.11 to 2.92)); and risk of severe flares (HR (95% CI): HDA1 intravenous 0.6 (0.37 to 0.81); HDA2 intravenous 0.6 (0.43 to 0.86); HDA1 subcutaneous 0.52 (0.30 to 0.92); HDA2 subcutaneous 0.59 (0.37 to 0.94)).ConclusionBroadening the HDA population to include either low complementorpositive anti-dsDNA, rather than both, would enable more UK patients to receive SLE treatment and experience improved clinical outcomes.
Association between Physical Activity and Inflammatory Markers in Community-Dwelling, Middle-Aged Adults
Authors: Cho So Mi Jemma , Lee Hokyou , Shim Jee-Seon , Jeon Justin Y , Kim Hyeon Chang 
Published: February 2021

Physical activity has been known to deter inflammatory process; yet, the evidence is scarce in healthy, middle-aged population. We assessed the association between physical activity and inflammatory biomarkers, including high sensitivity (hs) C-reactive protein (CRP), interleukin (IL)-1α, -1β, -6, tumor necrosis factor (TNF) -α, -β, and monocyte chemotactic protein (MCP) -1, -3. Functional and leisure-time physical activity was assessed by the International Physical Activity Questionnaire. Inflammatory biomarkers were measured by multiplex enzyme-linked immunosorbent assay. Compared to highly physically active participants based on total metabolic equivalent of task, the most sedentary group had significantly higher odds ratio (OR) and [95% confidence interval (CI)] for ≥75th percentile of TNF-α (1.64 [1.10-2.44]), TNF-β (1.50 [1.09-2.07]), IL-1β (2.14 [1.49-3.09]), hsIL-1β (1.72 [1.15-2.58]), IL-6 (1.84 [1.24-1.73]), hsIL-6 (2.05 [1.35-3.12]), and MCP-1 (1.91 [1.28-2.87]) levels. Results for IL-1α and MCP-3 were inconsistent, as the least active group had lower odds for above the median IL-1α (0.65 [0.49-0.95]) and MCP-3 (0.71 [0.54-0.93]) yet higher odds for ≥75th percentile IL-1α (2.36 [1.63-3.42]) and MCP-3 (2.44 [1.63-3.64]) levels. Based on duration of moderate-to-vigorous physical activity, sedentary participants had significantly higher odds for above median (1.40 [1.13-1.73]) and ≥75th percentile (1.33 [1.00-1.77]) IL-1β compared to those fulfilling the guideline recommendation. Subgroup analyses showed minimal sex differences. Routine inflammatory assessment may help to achieve primordial prevention of cardiovascular and metabolic diseases. NOVELTY ●Healthy, middle-aged adults with physically active lifestyle were generally at lower odds for elevated inflammatory status. ●The associations persisted regardless of sex, age, comorbidities, adiposity, and diet.
Do lake-specific characteristics mediate the temporal relationship between walleye growth and warming water temperatures?
Authors: Massie Danielle L. , Hansen Gretchen J.A. , Li Yan , Sass Greg G. , Wagner Tyler 
Published: February 2021

Walleye (Sander vitreus) population declines have been linked to climate change, but it is unclear how the growth of this cool-water species may be affected by warming water temperatures. Because warming rates vary among lakes, it is uncertain whether lake characteristics may mediate the temperature effects on walleye growth or may vary as a result of differences in lake habitat or productivity. In this study, we (i) quantified walleye annual growth from 1983 to 2015 in 61 lakes in midwestern United States; (ii) estimated the relationship between annual early life growth (ω; mm·year–1) and water growing degree days (GDD); and (iii) identified lake characteristics affecting loge(ω)–GDD relationships. On average, ω estimates significantly increased with increasing GDD; however, this relationship varied in direction and magnitude among lakes. We estimated an 84% posterior probability of a negative effect of water clarity on the loge(ω)–GDD relationship, suggesting that water clarity may mediate the effect of warming water temperatures by affecting the magnitude and direction of the loge(ω)–GDD relationship. Our results provide insights into the conservation of cool-water species in a changing environment and identify lakes characteristics in which walleye growth may be more resilient to climate change.
Contemporary status, distribution, and trends of mixedwoods in the northern United States
Authors: Vickers Lance A. , Knapp Benjamin O. , Kabrick John M. , Kenefic Laura S. , D’Amato Anthony W. , Kern Christel C. , MacLean David A. , Raymond Patricia , Clark Kenneth L. , Dey Daniel C. , Rogers Nicole S. 
Published: February 2021

As interest in managing and maintaining mixedwood forests in the northern United States (US) grows, so does the importance of understanding their abundance and distribution. We analyzed Forest Inventory and Analysis data for insights into mixedwood forests spanning 24 northern US states from Maine south to Maryland and westward to Kansas and North Dakota. Mixedwoods, i.e., forests with both hardwoods and softwoods present but neither exceeding 75%–80% of composition, comprise more than 19 million hectares and more than one-quarter of the northern US forest. They are most common in the Adirondack – New England, Laurentian, and Northeast ecological provinces but also occur elsewhere in hardwood-dominated ecological provinces. These mixtures are common even within forest types nominally categorized as either hardwood or softwood. The most common hardwoods within those mixtures were species of Quercus and Acer, and the most common softwoods were species of Pinus, Tsuga, and Juniperus. Although mixedwoods exhibited stability in total area during our analysis period, hardwood saplings were prominent, suggesting widespread potential for eventual shifts to hardwood dominance in the absence of disturbances that favor regeneration of the softwood component. Our analyses suggest that while most mixedwood plots remained mixedwoods, harvesting commonly shifts mixedwoods to either hardwood- or softwood-dominated cover types, but more specific information is needed to understand the causes of these shifts.
Validation of an optical potential for incident and emitted low-energy $$\alpha $$-particles in the $$A\sim 60$$ mass range
Authors: Avrigeanu V. , Avrigeanu M. 
Published: February 2021

AbstractA consistent set of statistical-model input parameters, validated by analysis of various independent data, makes possible the assessment of an $$\alpha $$
α
-particle optical model potential [Phys. Rev. C 90, 044612 (2014)] also for nucleon-induced $$\alpha $$
α
-emission within the $$A \sim 60$$

A
∼
60

mass-number range. The advantage of recent data for low-lying states feeding is taken as well. Consideration of additional reaction channels leading to increase of the $$\alpha $$
α
-emission beyond the statistical predictions has concerned the pickup direct interaction and Giant Quadrupole Resonance similar features.