bluuebunny/crossref_metadata_2025_split huggingface dataset:
Error Estimation and Adaptivity for Differential Equations with Multiple Scales in Time
Authors: Lautsch Leopold , Richter Thomas 
Published: April 2021

AbstractWe consider systems of ordinary differential equations with multiple scales in time. In general, we are interested in the long time horizon of a slow variable that is coupled to solution components that act on a fast scale. Although the fast scale variables are essential for the dynamics of the coupled problem, they are often of no interest in themselves. Recently, we have proposed a temporal multiscale approach that fits into the framework of the heterogeneous multiscale method and that allows for efficient simulations with significant speedups. Fast and slow scales are decoupled by introducing local averages and by replacing fast scale contributions by localized periodic-in-time problems. Here, we generalize this multiscale approach to a larger class of problems, but in particular, we derive an a posteriori error estimator based on the dual weighted residual method that allows for a splitting of the error into averaging error, error on the slow scale and error on the fast scale. We demonstrate the accuracy of the error estimator and also its use for adaptive control of a numerical multiscale scheme.
Decreased expression of annexin A2 and loss of its association with vascular endothelial growth factor leads to the deficient trophoblastic invasion in preeclampsia
Authors: Ruikar Komal , Aithala Manjunatha , Shetty Praveenkumar , Dinesh Udupi Shastry , Bargale Anil , Sadashiv Roshni , Edachery veedu Sarathkumar , Khode Vitthal , Neravi Asha , Patil Prakash 
Published: April 2021

Abstract

Objectives
Preeclampsia (PE) remains the major cause for maternal and foetal mortality and morbidity. Invasion of endovascular trophoblast and remodelling of spiral artery are crucial actions of normal placental development. Non-fulfilment of these processes plays a leading role in the development of preeclampsia. Vascular endothelial growth factor (VEGF) is produced by extravillous trophoblastic tissue and decidual cell population is a well-known angiogenic growth which plays a fundamental role in placental pathogenesis of PE. Annexin A2 (ANXA2) is a profibrinolytic protein receptor required for plasminolysis, which is an important step in the formation of new blood vessel along with VEGF. Role of ANXA2 is poorly studied in context with human reproductive disease like preeclampsia. The purpose of the present study is to examine the expression and association of VEGF and ANXA2 in the term placentas of pregnancies with and without PE.

Methods
The study group comprised of placental tissues procured from gestations with PE (n=30) and without (n=20) PE. The expression of VEGF and ANXA2 in the placental villous tissue was evaluated quantitatively by means of IHC, western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR).

Results
Our IHC, western blotting and RT-PCR analysis illustrated the significant decrease in the expression of VEGF and ANXA2 in PE group compared with the normotensive control group (p<0.005). We observed statistically significant positive correlation among the expression of ANXA2 and VEGF in placentas of normotensive control group (p<0.0001).

Conclusions
The diminished expression of VEGF and ANXA2 in placenta may be associated with the defective angiogenesis and which may possibly play a vital role in PE pathogenesis.
Coherence & Confirmation: The Epistemic Limitations of the Impossibility Theorems
Authors: Poston Ted 
Published: April 2021

Abstract
It is a widespread intuition that the coherence of independent reports provides a powerful reason to believe that the reports are true. Formal results by Huemer, M. 1997. “Probability and Coherence Justification.” Southern Journal of Philosophy 35: 463–72, Olsson, E. 2002. “What is the Problem of Coherence and Truth?” Journal of Philosophy XCIX (5): 246–72, Olsson, E. 2005. Against Coherence: Truth, Probability, and Justification. Oxford University Press., Bovens, L., and S. Hartmann. 2003. Bayesian Epistemology. Oxford University Press, prove that, under certain conditions, coherence cannot increase the probability of the target claim. These formal results, known as ‘the impossibility theorems’ have been widely discussed in the literature. They are taken to have significant epistemic upshot. In particular, they are taken to show that reports must first individually confirm the target claim before the coherence of multiple reports offers any positive confirmation. In this paper, I dispute this epistemic interpretation. The impossibility theorems are consistent with the idea that the coherence of independent reports provides a powerful reason to believe that the reports are true even if the reports do not individually confirm prior to coherence. Once we see that the formal discoveries do not have this implication, we can recover a model of coherence justification consistent with Bayesianism and these results. This paper, thus, seeks to turn the tide of the negative findings for coherence reasoning by defending coherence as a unique source of confirmation.
Ignition–extinction analysis of catalytic reactor models
Authors: Balakotaiah Vemuri , Sun Zhe , Ratnakar Ram 
Published: April 2021

Abstract
A detailed analysis of the ignition–extinction and hysteresis behavior of the two widely used catalytic reactor models (packed-bed and monolith) for the case of a single exothermic reaction is presented. First, limiting models are used to determine the minimum adiabatic temperature rise and/or catalyst activity needed to observe hysteresis behavior. Next, explicit expressions are provided for estimating the feed temperature or space time at ignition (light-off) and extinction (blow-out) as a function of the adiabatic temperature rise (or inlet concentration of limiting reactant), effective thermal conductivity, time and length scales (reactor, tube/channel diameter, effective diffusion length and pore size), catalyst activity (or dilution) and heat loss. It is shown that various limiting reactor models such as the thin-bed, long-bed, lumped thermal, adiabatic and strongly cooled cases that are defined in terms of various inter- and intraphase heat and mass dispersion time scales can be used to derive scaling relations that are useful in predicting the ignition/extinction loci for both laboratory scale (with heat exchange) and large scale (near adiabatic) reactors.
The Maldives Heritage Survey
Authors: Feener R. Michael , Daly Patrick , Frachetti Michael , Mujah Ibrahim , Irawani Maida , Taran Jovial Pally , Zaki Ahmad , Maasa Fathimath , Shamran Mohamed , Zahara Multia , Azees Mariyam Isha , Baranyai Krisztina , Levick Paula , Bakheit Hala , Rahardjo Jessica , Clark Gabriel 
Published: April 2021

AbstractThe Maldives Heritage Survey was established to document cultural heritage vulnerable to human and environmental threats in the Maldives. An open-access online database is being produced to inform academic studies, support heritage-management plans and create a permanent archive of digital heritage resources.
Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1
Authors: Yang Ya Lan , Lai Ted Weita 
Published: April 2021

Pain at the injection site is a common complaint of patients receiving therapeutic formulations containing citric acid. Despite the widely acknowledged role of acid-sensing ion channels (ASICs) in acid-related perception, the specific ASIC subtype mediating pain caused by subcutaneous acid injection and the mechanism by which citrate affects this process are less clear. Here, male mice subjected to intraplantar acid injection responded by executing a withdrawal reflex, and this response was abolished by ASIC1 but not ASIC2 knockout. Although intraplantar injection of neutral citrate solution did not produce this response, intraplantar injection of acidic citrate solution produced a withdrawal reflex greater than that produced by acidity alone. Consistent with the behavioral data, neutral citrate failed to produce an electrophysiological response in HEK293 cells, which express ASIC1, but acidic citrate produced a whole-cell inward current greater than that produced by acidity alone. Saturating the intracellular solution with citrate had no effect on the potentiating effect of extracellular citrate, suggesting that citrate acted extracellularly to potentiate ASIC1. Moreover, exposure to citrate immediately before acid stimulation failed to potentiate ASIC1 currents, which ruled out the involvement of a metabotropic receptor gated by a citrate metabolite. Finally, removal of calcium ions from the extracellular solution mimicked the potentiating effect of citrate and prevented citrate from further potentiating ASIC1. Our data demonstrate that ASIC1 is necessary for the nociceptive response caused by subcutaneous acid infusion and that neutral citrate, despite not inducing ASIC1 currents or nociceptive behavior on its own, potentiates acid nociception by removing the inhibitory effect of extracellular calcium ions on ASIC1.SIGNIFICANCE STATEMENTCitric acid is a common ingredient used in pharmaceutical formulations. Despite the widespread clinical use of these formulations, it remains unclear how citric acid causes pain when injected into patients. We identified ASIC1 as the key receptor used to detect injection-site pain caused by acid, and we showed that neutral citrate does not stimulate ASIC1; instead, citrate substantially potentiates ASIC1 activation when injected simultaneously with acid. In addition, we demonstrated that citrate potentiates ASIC1 by removing the inhibitory action of calcium on the extracellular side of the receptor. Given that injection-site pain is the primary complaint of patients receiving citrate-containing medical products, our data provide mechanistic insight into a common medical complaint and suggest a means of avoiding injection pain.
mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease
Authors: Van Skike Candice E. , Hussong Stacy A. , Hernandez Stephen F. , Banh Andy Q. , DeRosa Nicholas , Galvan Veronica 
Published: April 2021

Vascular dysfunction is a universal feature of aging and decreased cerebral blood flow has been identified as an early event in the pathogenesis of Alzheimer's disease (AD). Cerebrovascular dysfunction in AD includes deficits in neurovascular coupling (NVC), a mechanism that ensures rapid delivery of energy substrates to active neurons through the blood supply. The mechanisms underlying NVC impairment in AD, however, are not well understood. We have previously shown that mechanistic/mammalian target of rapamycin (mTOR) drives cerebrovascular dysfunction in models of AD by reducing the activity of endothelial nitric oxide synthase (eNOS), and that attenuation of mTOR activity with rapamycin is sufficient to restore eNOS-dependent cerebrovascular function. Here we show mTOR drives NVC impairments in an AD model through the inhibition of neuronal NOS (nNOS)- and non-NOS-dependent components of NVC, and that mTOR attenuation with rapamycin is sufficient to restore NVC and even enhance it above WT responses. Restoration of NVC and concomitant reduction of cortical amyloid-β levels effectively treated memory deficits in 12-month-old hAPP(J20) mice. These data indicate that mTOR is a critical driver of NVC dysfunction and underlies cognitive impairment in an AD model. Together with our previous findings, the present studies suggest that mTOR promotes cerebrovascular dysfunction in AD, which is associated with early disruption of nNOS activation, through its broad negative impact on nNOS as well as on non-NOS components of NVC. Our studies highlight the potential of mTOR attenuation as an efficacious treatment for AD and potentially other neurologic diseases of aging.SIGNIFICANCE STATEMENTFailure of the blood flow response to neuronal activation [neurovascular coupling (NVC)] in a model of AD precedes the onset of AD-like cognitive symptoms and is driven, to a large extent, by mammalian/mechanistic target of rapamycin (mTOR)-dependent inhibition of nitric oxide synthase activity. Our studies show that mTOR also drives AD-like failure of non-nitric oxide (NO)-mediated components of NVC. Thus, mTOR attenuation may serve to treat AD, where we find that neuronal NO synthase is profoundly reduced early in disease progression, and potentially other neurologic diseases of aging with cerebrovascular dysfunction as part of their etiology.
Ambivalence in the Kierkegaardian Conception of Angest
Authors: Grigas Justinas 
Published: April 2021

The paper considers two problems related to the interpretation of S. Kierkegaard’s conception of Angest. Firstly, a tendency to interpret Kierkegaard’s Angest as a “fear without an object” and to posit its similarity to Heidegger’s Angst is put in question. Questioning this interpretation, an analysis of The Concept of Anxiety is undertaken, in order to reveal ambivalence as the primary feature of Kierkegaard’s conception of Angest. Secondly, the question of translating Angest into Lithuanian is addressed, criticizing the established tradition of translating Angest as “baimė” (fear) and supporting translator’s I. Tomaševičiūtė’s choice of “nerimas”. The aforementioned ambivalence of Angest serves as the basis for the critique, revealing Angest as a paradoxical attraction to that, which frightens. The first part of the paper expounds on the moment of ambivalence in the descriptions of Angest, found in The Concept of Anxiety. The second part compares and underlines the differences between the philosophical approaches of Kierkegaard and Heidegger. It is shown that Kierkegaard’s attention to the ambivalence of Angest is related to the practical bent of Kierkegaard’s philosophy and the problematics of personal individuation.
Indicators of dental status in professional sportswomen
Authors: Safaraliyev F. R. 
Published: April 2021

Objective. To study the indicators of the dental status in professional athletes.
Materials and methods. The object of the study was 200 professional female athletes representing various kinds of sport and 200 practically healthy female individuals who are not involved in sports. The total sports experience of the subjects was on average 1315 years. The prevalence of periodontal diseases among female athletes was determined using the CPITN index. The prevalence and intensity of caries was determined by the CPI index. The hygienic state of the oral cavity was determined using the oral hygiene efficiency index (PHP). In the main group, patients were administered applications of a drug based on propolis and vegetable oil for two weeks; in the comparison group, the traditional antiseptic, chlorhexidine bigluconate, was used for the same period.
Results. In the control group, the prevalence of chronic generalized gingivitis was on average two times less than in the main group, in which the value of this indicator varied within 50 %. Among all the studied diseases of the oral cavity in athletes in general, the most essential and significant differences were observed in relation to the prevalence of dental caries and its complications, which were more common in the group of athletes than in the control group 95.0 1.54 %, versus 89.5 2.17 %, respectively (p 0.001). The need for treatment of moderate and severe inflammatory periodontal diseases in the main group was approximately 1.5 times higher than in the control group (77.0 2.98 vs. 42.5 3.50 %, p 0.001), and for gingivitis almost 2 times higher than in the control group (61.5 3.44 vs. 39.0 3.45 %, p 0.001). The results of the study showed that among the oral diseases in sportswomen, the most essential and significant differences were observed in the prevalence of dental caries and its complications. The intensity of periodontal tissue damage over the entire period of sports career in athletes of the older age group corresponded to moderate and severe periodontitis. The high percentage of cases of major dental diseases detected among female athletes indicates their high need for periodontal care.
Conclusions. Regular use of a biologically neutral propolis-based preparation for preventive purposes leads to a relatively more pronounced improvement in laboratory and clinical indicators of the oral cavity status.
Pelaksanaan Ketentuan Dan Penyelesaian Hambatan Pada Pembangunan Apartemen
Authors: Magatri Alia Laksmi Dyah , Sunarno Sunarno 
Published: April 2021

Perkembangan penduduk di Kota Yogyakarta terbilang cukup pesat sehingga membuat kebutuhan primer akan hunian pun juga ikut meningkat pesat. Terbatasnya lahan yang ada di Yogyakarta dan harga yang terus meningkat membuat beberapa masyarakat Yogyakarta tidak dapat memiliki hunian tunggal. Hunian atau tempat tinggal bersama dipilih untuk menjadi solusi penyediaan hunian bagi masyarakat yang tidak dapat membeli hunian tunggal. Hunian bersama yang sudah ada di Yogyakarta seperti rumah susun dan apartemen juga sudah banyak diminati beberapa masyarakat di Yogyakarta untuk memenuhi kebutuhan akan tempat tinggalnya. Dalam usaha pemenuhan kebutuhan akan tempat tinggal, pembangunan rumah susun dan apartemen memiliki proses yang cukup panjang dari mulai pengajuan perizinan hingga pembangunan rumah susun dan apartemen tersebut. Dalam proses pengajuan izinnya sendiri dapat memakan waktu yang cukup lama dikarenakan prosedurnya sendiri yang juga cukup panjang. Pemmbanunan baru akan dilakukan apabila semua persyaratan telah terpenuhi dan izin telah keluarkan oleh pihak yang berwewenang atas pengajuan izin pihak yang bersangkutan (pembangun). Dalam pembangunan apartemen maupun rumah susun juga tidak jarang terjadi hambatan baik faktor internal maupun eksternal hambatan dari faktor internal biasanya terjadi apabila syarat pembangunan belum terpenuhi secara sempurna, sedangkan hambatan dari faktor eksternal biasanya terjadi karena kurangnya komunikasi atau sosialisasi dengan masyarakat setempat sehingga sering terjadi kesalahpahaman. Solusinya dengan memenuhi semua persyaratan dalam prmbangunan dan juga melakukan sosialisasi kepada masyarakat setempat agar tidak terjadi sengketa.
Physical Condition Comparison between Female Athlete Indoor Hockey of East Java Team and National Team
Authors: Oemar Fitry Nachamory , Subagio Irmantara , Setiawan Hayuris Kinandita , Rejeki Purwo Sri 
Published: April 2021

ABSTRACTThe purpose of this research is to describe the physical condition differences between female athletes indoor hockey of East Java Team and National Team. Data sampling is taken from 12 female athletes indoor hockey of PON 2016 with age range 17-28 years old and 12 athletes of indoor hockey of Indonesia’s National Team at SEA Games 2017 with age range 19-28 years old for comparison. Physical condition that measured is VO2max to represent endurance, abdominal muscle strength, speed and flexibility. Obtained data is then analyzed using SPSS. VO2max of East Java Team is (39.54±4.18) ml/kg/minute and for National Team is (43.43±7.59) ml/kg/minute (ρ=0.14). For abdominal muscle strength, East Java Team has (41.50±7.01) kg and National Team has (51.83±3.32) kg (ρ=0.00). For Speed, East Java Team has (3.59±0.30) second and National Team has (3.94±0.38) second (ρ=0.51). For Flexibility, East Java Team has (23.75±5.10) cm and National Team has (29.50±4.91) cm (ρ=0.01). From these data we can conclude that East Java Team physical condition is under National Team and it has significant differences at flexibility and abdominal muscle strength. Furthermore, optimal interventions are needed to improve both of those physical conditions.Keywords: hockey, endurance, flexibility, strength, speed
Oxidative degradation of p-chlorophenol by the persulfate-doped Fe-Mn bimetallic hydroxide, the parametrical significance, and systematical optimization
Authors: Huang Tao , Du Jing , Yu Danni , Deng Shihan , Zhang Shuwen , Liu Longfei 
Published: April 2021

Abstract
Aqueous Fe(II)-catalyzed activation commonly deteriorates the oxidation performance of persulfate (PS) to the treatment of organic contaminants. In this study, a PS-doped layered bimetallic hydroxide (Fe-Mn hydroxide) was synthesized to construct a heterogeneously catalytic system to solve the issue brought by homogeneity. The molar ratio of Fe(II) to Mn(II) and the mass ratio of PS to Fe-Mn hydroxide both had a significant impact on the catalytic degradation of p-CP. Reaction temperatures engaged in the most essential role in influencing the degradation and removal of p-chlorophenol (p-CP). The optimal combination of factors for the preparation of PS-hydroxide and the treatment of p-CP was finally determined by significance analysis. The degradation process was appropriately fitted by the pseudo-first-order kinetic model. the benzene ring in p-CP was broken by PS-hydroxide during the adsorption. The surface modification of PS-hydroxide caused by the valence transition of Mn was beneficial to the adsorption and catalytic degradation of p-CP.CapsuleA persulfate-doped layered bimetallic hydroxide was synthesized to construct a heterogeneously catalytic system to solve the drawback of homogeneity for the effective treatment of p-chlorophenol.
The costs of positon, velocity and force requirements in optimal control induce triphasic muscle activation during reaching movement
Authors: Ueyama Yuki 
Published: April 2021

Abstract
The nervous system activates a pair of agonist and antagonist muscles to determine the muscle activation pattern for a desired movement. Although there is a problem with redundancy, it is solved immediately, and movements are generated with characteristic muscle activation patterns in which antagonistic muscle pairs show alternate bursts with a triphasic shape. To investigate the requirements for deriving this pattern, this study simulated arm movement numerically by adopting a musculoskeletal arm model and an optimal control based on the minimization of neural input. The simulation reproduced the triphasic electromyogram (EMG) pattern observed in a reaching movement using a cost function that considered three terms: end-point position, velocity, and force required. The first, second and third bursts of muscle activity were generated by the cost terms of position, velocity and force, respectively. Thus we concluded that the costs of position, velocity and force requirements in optimal control can induce triphasic EMG patterns. Therefore we suggest that the nervous system may control the body by using an optimal control mechanism that adopts the costs of position, velocity and force required, which serve to initiate, decelerate and stabilize movement, respectively.