bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Zeolite‐confined Pd/Acid Sites for High Efficiency of B−H Cleavage
Authors: Liu Jia‐Wen , Wu Si‐Ming , Wang Yi‐Tian , Qin Yuan , Wu Jing‐Xian , Wang Li‐Ying , Tian Ge , Zhao Xiao‐Fang , Yang Xiao‐Yu 
Published: March 2021

AbstractConfining noble nanometal in zeolite framework is a promising way to improve its efficiency and durability for catalytic reactions. Herein, the synergistic effect of Pd nanoparticles and intrinsic acid sites in zeolite on promoting hydrogen generation performance is demonstrated. Pd nanoparticles are embedded into macroporous ZSM‐5 (designed as Pd@ZSM‐5) via a steam‐thermal strategy. The confined Pd and acid sites in Pd@ZSM‐5 synergistically promote the activation of ammonia borane (AB) and water molecules, resulting in the enhanced H2 generation rates for AB hydrolysis. The interaction of Pd and acid sites in zeolite is further confirmed by solid‐state NMR techniques and the key aspect is the confinement effect of zeolite. Furthermore, Pd@ZSM‐5 shows high activity and durability in tandem hydrogenation of nitrobenzene.
No-go theorems on localization of gravity around higher codimensional branes in noncompact extra dimensions
Authors: Li Shing Yan 
Published: March 2021

Abstract
We study the brane world scenario of a single brane (or a single stack of branes) with codimension higher than one. When the extra dimensions are not small, localization of gravity around the brane is needed in order to reproduce the observable four-dimensional gravity. We focus on the case of noncompact extra dimensions, where the possibility of localized gravity becomes non-trivial. We show that in large class of gravity models, localization of massless gravity is not possible for codimension-2 branes with at least one noncompact extra dimension. With additional mild assumptions on field backgrounds, we also show that it is not possible for higher codimensional branes with two or more noncompact extra dimensions.
About magnetic AdS black holes
Authors: McInnes Brett 
Published: March 2021

Abstract
There has recently been a strong revival of interest in quasi-extremal magnetically charged black holes. In the asymptotically flat case, it is possible to choose the magnetic charge of such an object in such a manner that the black hole is surrounded by a corona in which electroweak symmetry is restored on macroscopic scales, a result of very considerable interest. We argue that holographic duality indicates that the asymptotically AdS analogues of these black holes have several interesting properties: the dual theory is only physical if the black hole is required to rotate; in the rotating case, the magnetic field at the poles does not attain its maximum on the event horizon, but rather somewhat outside it; the magnetic field at the equator is not a monotonically decreasing function of the magnetic charge; the electric fields induced by the rotation, while smaller than their magnetic counterparts, are by no means negligible; the maximal electric field often occurs neither at the poles nor at the equator; and so on. Most importantly, in the magnetically charged case it is possible to avoid the superradiant instability to which neutral AdS-Kerr black holes are subject; but the need to avoid this instability imposes upper bounds on the magnetic and electric fields. In some circumstances, therefore, the corona may not exist in the asymptotically AdS case.
Dark photon from light scalar boson decays at FASER
Authors: Araki T. , Asai K. , Otono H. , Shimomura T. , Takubo Y. 
Published: March 2021

Abstract
FASER is one of the promising experiments which search for long-lived particles beyond the Standard Model. In this paper, we focus on dark photon associating with an additional U(1) gauge symmetry, and also a scalar boson breaking this U(1) gauge symmetry. We study the sensitivity to the dark photon originated from U(1)-breaking scalar decays. We find that a sizable number of dark photon signatures can be expected in wider parameter space than previous studies.
Quark and lepton mass and mixing with non-universal Z′ from a 5d Standard Model with gauged SO(3)
Authors: de Anda Francisco J. , King Stephen F. 
Published: March 2021

Abstract
We propose a theory of quark and lepton mass and mixing with non-universal Z′ couplings based on a 5d Standard Model with quarks and leptons transforming as triplets under a new gauged SO(3) isospin. In the 4d effective theory, the SO(3) isospin is broken to U(1)′, through a S1/(ℤ2×$$ {\mathrm{\mathbb{Z}}}_2^t $$

ℤ
2
t

) orbifold, then subsequently dynamically broken, resulting in a massive Z′. Quarks and leptons in the 5d bulk appear as massless modes, with zero Yukawa couplings to the Higgs on the brane, and zero couplings to Z′, at leading order, due to the U(1)′ symmetry. However, after the U(1)′ breaking, both Yukawa couplings and non-universal Z′ couplings are generated by heavy Kaluza-Klein exchanges. Hierarchical quark and lepton masses result from a hierarchy of 5d Dirac fermion masses. Neutrino mass and mixing arises from a novel type Ib seesaw mechanism, mediated by Kaluza-Klein Dirac neutrinos. The non-universal Z′ couplings may contribute to semi-leptonic B decay ratios which violate μ − e universality. In this model such couplings are related to the corresponding quark and lepton effective Yukawa couplings.
Selected Clinical Features Fail to Predict Inflammatory Gene Expressions for TNF-α, TNFR1, NSMAF, Casp3 and IL-8 in Tendons of Patients with Rotator Cuff Tendinopathy
Authors: Struzik Slawomir , Czarkowska-Paczek Bozena , Wyczalkowska-Tomasik Aleksandra , Maldyk Paweł , Paczek Leszek 
Published: March 2021

AbstractThe pathophysiology of rotator cuff tendinopathy is not fully understood, particularly in terms of the local inflammatory process. This study aimed to investigate the expression of selected molecules in the tumour necrosis factor (TNF)-α transduction pathway, including TNF-α, TNF receptor 1 (TNFR1), neutral sphingomyelinase activation associated factor (NSMAF), caspase 3 (Casp3), and interleukin (IL)-8, in patients with rotator cuff tendinopathy that had undergone surgical treatment. We included 44 participants that underwent arthroscopy, due to rotator cuff tendinopathy. Samples from the injured tendon were collected during arthroscopy, and RT-PCR was performed to determine gene expression. Pearson correlation analyses or U-Mann–Whitney test were performed to identify associations with the following parameters: sex, age at admission, body mass index, the presence of night pain, previous treatment (nonsteroidal anti-inflammatory drugs and/or steroids), medical history of the shoulder injury, upper subluxation of the humeral head, and the number of tendons injured. RT-PCR showed that the selected pro-inflammatory factors involved in the TNF-α signalling pathway expression levels were expressed in the tendon tissues. However, the levels of expression varied from patient to patient. Variations were over 250-fold for TNF-α, about 130-fold for TNFR1, NSMAF, and Casp3, and 1000-fold for IL-8. We could not confirm that any of the clinical parameters investigated were associated with the level of gene expression in the TNF-α pathway and IL-8.
The circadian clock and metabolic homeostasis: entangled networks
Authors: de Assis Leonardo Vinícius Monteiro , Oster Henrik 
Published: March 2021

AbstractThe circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with biological processes and with the internal circadian clock. In this review, it is provided an in-depth view of the molecular functioning of the circadian molecular clock, how this system is organized, and how central and peripheral clocks communicate with each other. In this sense, we provide an overview of the neuro-hormonal factors controlled by the central clock and how they affect peripheral tissues. We also evaluate signals released by peripheral organs and their effects in the central clock and other brain areas. Additionally, we evaluate a possible communication between peripheral tissues as a novel layer of circadian organization by reviewing recent studies in the literature. In the last section, we analyze how the circadian clock can modulate intracellular and tissue-dependent processes of metabolic organs. Taken altogether, the goal of this review is to provide a systemic and integrative view of the molecular clock function and organization with an emphasis in metabolic tissues.
Dynamic conformal cooling improves injection molding
Authors: Kirchheim Andreas , Katrodiya Yogeshkumar , Zumofen Livia , Ehrig Frank , Wick Curdin 
Published: March 2021

AbstractTo achieve a certain visual quality or acceptable surface appearance in injection-molded components, a higher mold surface temperature is needed. In order to achieve this, injection molds can be dynamically tempered by integrating an active heating and cooling process inside the mold halves. This heating and cooling of the mold halves becomes more efficient when the temperature change occurs closer to the mold surface. Complex channels that carry cold or hot liquids can be manufactured close to the mold surface by using the layer by layer principle of additive manufacturing. Laser powder bed fusion (L-PBF), as an additive manufacturing process, has special advantages; in particular, so-called hybrid tools can be manufactured. For example, complex tool inserts with conformal cooling channels can be additively built on simple, machined baseplates. This paper outlines the thermal simulation carried out to optimize the injection molding process by use of dynamic conformal cooling. Based on the results of this simulation, a mold with conformal cooling channels was designed and additively manufactured in maraging steel (1.2709) and then experimentally tested.
Does sonification of action simulation training impact corticospinal excitability and audiomotor plasticity?
Authors: Castro Fabio , Osman Ladan , Di Pino Giovanni , Vuckovic Aleksandra , Nowicky Alexander , Bishop Daniel 
Published: March 2021

AbstractSonification is a sensory augmentation strategy whereby a sound is associated with, and modulated by, movement. Evidence suggests that sonification could be a viable strategy to maximize learning and rehabilitation. Recent studies investigated sonification of action observation, reporting beneficial effects, especially in Parkinson’s disease. However, research on simulation training—a training regime based on action observation and motor imagery, in which actions are internally simulated, without physical execution—suggest that action observation alone is suboptimal, compared to the combined use of action observation and motor imagery. In this study, we explored the effects of sonified action observation and motor imagery on corticospinal excitability, as well as to evaluate the extent of practice-dependent plasticity induced by this training. Nineteen participants were recruited to complete a practice session based on combined and congruent action observation and motor imagery (AOMI) and physical imitation of the same action. Prior to the beginning, participants were randomly assigned to one of two groups, one group (nine participants) completed the practice block with sonified AOMI, while the other group (ten participants) completed the practice without extrinsic auditory information and served as control group. To investigate practice-induced plasticity, participants completed two auditory paired associative stimulation (aPAS) protocols, one completed after the practice block, and another one completed alone, without additional interventions, at least 7 days before the practice. After the practice block, both groups significantly increased their corticospinal excitability, but sonification did not exert additional benefits, compared to non-sonified conditions. In addition, aPAS significantly increased corticospinal excitability when completed alone, but when it was primed by a practice block, no modulatory effects on corticospinal excitability were found. It is possible that sonification of combined action observation and motor imagery may not be a useful strategy to improve corticospinal, but further studies are needed to explore its relationship with performance improvements. We also confirm the neuromodulatory effect of aPAS, but its interaction with audiomotor practice remain unclear.
Number of Directions Determined by a Set in $$\mathbb {F}_{q}^{2}$$ and Growth in $$\mathrm {Aff}(\mathbb {F}_{q})$$
Authors: Dona Daniele 
Published: March 2021

AbstractWe prove that a set A of at most q non-collinear points in the finite plane $$\mathbb {F}_{q}^{2}$$

F

q

2

spans more than $${|A|}/\!{\sqrt{q}}$$

|
A
|

/

q

directions: this is based on a lower bound by Fancsali et al. which we prove again together with a different upper bound than the one given therein. Then, following the procedure used by Rudnev and Shkredov, we prove a new structural theorem about slowly growing sets in $$\mathrm {Aff}(\mathbb {F}_{q})$$

Aff
(

F
q

)

for any finite field $$\mathbb {F}_{q}$$

F
q

, generalizing the analogous results by Helfgott, Murphy, and Rudnev and Shkredov over prime fields.
A harmonically weighted filter for cyclical long memory processes
Authors: Maddanu Federico 
Published: March 2021

AbstractThe estimation of the long memory parameter d is a widely discussed issue in the literature. The harmonically weighted (HW) process was recently introduced for long memory time series with an unbounded spectral density at the origin. In contrast to the most famous fractionally integrated process, the HW approach does not require the estimation of the d parameter, but it may be just as able to capture long memory as the fractionally integrated model, if the sample size is not too large. Our contribution is a generalization of the HW model, denominated the Generalized harmonically weighted (GHW) process, which allows for an unbounded spectral density at $$k \ge 1$$

k
≥
1

frequencies away from the origin. The convergence in probability of the Whittle estimator is provided for the GHW process, along with a discussion on simulation methods. Fit and forecast performances are evaluated via an empirical application on paleoclimatic data. Our main conclusion is that the above generalization is able to model long memory, as well as its classical competitor, the fractionally differenced Gegenbauer process, does. In addition, the GHW process does not require the estimation of the memory parameter, simplifying the issue of how to disentangle long memory from a (moderately persistent) short memory component. This leads to a clear advantage of our formulation over the fractional long memory approach.
Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies
Authors: Saul Nadine , Möller Steffen , Cirulli Francesca , Berry Alessandra , Luyten Walter , Fuellen Georg 
Published: March 2021

AbstractSeveral biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the “Healthy Worm Database” (http://healthy-worm-database.eu). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans-based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.
TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection
Authors: Zhou Hongli , Zhou Minyu , Hu Yue , Limpanon Yanin , Ma Yubin , Huang Ping , Dekumyoy Paron , Maleewong Wanchai , Lv Zhiyue 
Published: March 2021

AbstractAngiostrongylus cantonensis (AC) can cause severe eosinophilic meningitis or encephalitis in non-permissive hosts accompanied by apoptosis and necroptosis of brain cells. However, the explicit underlying molecular basis of apoptosis and necroptosis upon AC infection has not yet been elucidated. To determine the specific pathways of apoptosis and necroptosis upon AC infection, gene set enrichment analysis (GSEA) and protein–protein interaction (PPI) analysis for gene expression microarray (accession number: GSE159486) of mouse brain infected by AC revealed that TNF-α likely played a central role in the apoptosis and necroptosis in the context of AC infection, which was further confirmed via an in vivo rescue assay after treating with TNF-α inhibitor. The signalling axes involved in apoptosis and necroptosis were investigated via immunoprecipitation and immunoblotting. Immunofluorescence was used to identify the specific cells that underwent apoptosis or necroptosis. The results showed that TNF-α induced apoptosis of astrocytes through the RIP1/FADD/Caspase-8 axis and induced necroptosis of neurons by the RIP3/MLKL signalling pathway. In addition, in vitro assay revealed that TNF-α secretion by microglia increased upon LSA stimulation and caused necroptosis of neurons. The present study provided the first evidence that TNF-α was secreted by microglia stimulated by AC infection, which caused cell death via parallel pathways of astrocyte apoptosis (mediated by the RIP1/FADD/caspase-8 axis) and neuron necroptosis (driven by the RIP3/MLKL complex). Our research comprehensively elucidated the mechanism of cell death after AC infection and provided new insight into targeting TNF-α signalling as a therapeutic strategy for CNS injury.
Observations of greenhouse gases as climate indicators
Authors: Bruhwiler Lori , Basu Sourish , Butler James H. , Chatterjee Abhishek , Dlugokencky Ed , Kenney Melissa A. , McComiskey Allison , Montzka Stephen A. , Stanitski Diane 
Published: March 2021

AbstractHumans have significantly altered the energy balance of the Earth’s climate system mainly not only by extracting and burning fossil fuels but also by altering the biosphere and using halocarbons. The 3rd US National Climate Assessment pointed to a need for a system of indicators of climate and global change based on long-term data that could be used to support assessments and this led to the development of the National Climate Indicators System (NCIS). Here we identify a representative set of key atmospheric indicators of changes in atmospheric radiative forcing due to greenhouse gases (GHGs), and we evaluate atmospheric composition measurements, including non-CO2 GHGs for use as climate change indicators in support of the US National Climate Assessment. GHG abundances and their changes over time can provide valuable information on the success of climate mitigation policies, as well as insights into possible carbon-climate feedback processes that may ultimately affect the success of those policies. To ensure that reliable information for assessing GHG emission changes can be provided on policy-relevant scales, expanded observational efforts are needed. Furthermore, the ability to detect trends resulting from changing emissions requires a commitment to supporting long-term observations. Long-term measurements of greenhouse gases, aerosols, and clouds and related climate indicators used with a dimming/brightening index could provide a foundation for quantifying forcing and its attribution and reducing error in existing indicators that do not account for complicated cloud processes.
A phase Ib, open label, dose escalation trial of the anti-CD37 monoclonal antibody, BI 836826, in combination with ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia
Authors: Danilov Alexey V. , Spurgeon Stephen E. , Siddiqi Tanya , Quinson Anne-Marie , Maier Daniela , Smith Dionne , Brown Jennifer R. 
Published: March 2021

SummaryBI 836826 is a chimeric immunoglobulin G1 antibody targeting CD37, a transmembrane protein expressed on normal and malignant B cells. This open-label, phase Ib, dose-escalation study was conducted to determine the recommended phase II dose (RP2D) of BI 836826 + ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Eligible patients received 420 mg/day of ibrutinib with escalating doses of BI 836826. BI 836826 was administered in 4-week cycles. After Cycle 12, patients achieving complete response (CR), CR with incomplete marrow recovery, or minimal residual disease-negative partial response could continue to receive BI 836826 + ibrutinib every 4 weeks for ≤ 12 additional cycles. Patients received either 100 mg (n = 3) or 200 mg (n = 3) BI 836826 + ibrutinib. In the 100 mg BI 836826 cohort, one patient received two cycles and two patients received 22 cycles of BI 836826. In the 200 mg BI 836826 cohort, patients received 12, 16 and 20 cycles of BI 836826, respectively. All patients discontinued BI 836826 and continued ibrutinib outside the trial. No dose-limiting toxicities were reported in the maximum tolerated dose (MTD) evaluation period. As the trial was discontinued before the MTD was reached, the RP2D was not determined. Grade 3/4 adverse events (AEs) were predominantly hematological. Pseudomonal bacteremia was the only drug-related AE of special interest. BI 836826 + ibrutinib did not exceed the MTD at doses up to 200 mg in patients with CLL. However, RP2D and MTD were not formally established, as the sponsor discontinued the trial.
How to deal with low-flow low-gradient aortic stenosis and reduced left ventricle ejection fraction: from literature review to tips for clinical practice
Authors: Contorni F. , Fineschi M. , Iadanza A. , Santoro A. , Mandoli G. E. , Cameli M. 
Published: March 2021

AbstractLow-flow low-gradient aortic stenosis (LFLG AS) with reduced left ventricle ejection fraction (LVEF) is still a diagnostic and therapeutic challenge. The aim of this paper is to review the latest evidences about the assessment of the valvular disease, usually difficult because of the low-flow status, and the therapeutic options. Special emphasis is given to the available diagnostic tools for the characterization of LFLG AS without functional reserve at stress echocardiography and to the factors that clinicians should evaluate to choose between surgical aortic valve repair, transcatheter aortic valve implantation, or medical therapy.
Investigating Botanical Tributes in Post-Medieval British Burials: Archaeological Evidence from Three Burial Grounds
Authors: Ives Rachel 
Published: March 2021

AbstractArchaeological evidence from Britain shows botanical inclusions formed part of the post-medieval funeral. Findings from the analysis of three burial grounds consider the extent of demographic, socioeconomic, and local variation in the manner of tributes. Twenty-six of 1431 excavated burials showed evidence for flowers placed inside or bouquets or wreaths placed on top of the coffins, and adults and children had received botanical tributes. The use of tributes increased during the later nineteenth century but local variation existed in the manner and extent of botanical tributes adopted but trends can be affected by biases introduced by preservation and survival between different sites.