bluuebunny/crossref_metadata_2025_split huggingface dataset:
A practice guideline and decision aid for blood transfusion
Authors: Littenberg B. , Corwin H. , Gettinger A. , Leichter J. , AuBuchon J. 
Published: May 2021

Abstract
An attempt was made to reduce exposure of patients to blood products by using a point-of-ordering decision support system and strict adherence to a practice guideline, by observing physician behavior in the multidisciplinary intensive-care unit (ICU) of a tertiary-care medical center. Hemoglobin (Hg) level at the time of transfusion, total units of red blood cells (RBCs) per admission, units per patient per ICU day. fraction of patients receiving no transfusions, and incidence of single-unit transfusions covering 628 patients were measured. In Phase 1, RBC transfusion behavior was observed without intervention. In Phase 2, a special order form for RBCs that suggested a transfusion threshold of 8.6 g/dL of Hg was introduced. In Phase 3, the suggested threshold was lowered to 7.0 g/dL and required all trans-fusions that did not meet the new guideline to be prospectively reviewed by a transfusion medicine physician. The Hg level at trans-fusion fell from 8.5 g/dL to 8.2 g/dL (p = 0.008). The use of single-unit transfusions fell from 32 percent to 17 percent (p = 0.001), but there was no change in the number of patients receiving any blood, the total units per admission, or units per patient per day. In this setting, a practice guideline with a point-of-decision support system did not influence blood usage. Intermediate outcomes (such as the level of anemia at transfusion or compliance to a guideline) should not substitute for more substantial outcomes (reduction in blood use or vims exposure) in assessing medical practices.
The Relationship Between the Severity of Coronary Artery Disease and
Erythrocyte Morphology Parameters Measured by New-Generation
Hematology Analyzer
Authors: Gönel Ataman , Yasak Ibrahin Halil , Tascanov Mustafa Begenc , Seyhanli Eyyup Sabri 
Published: May 2021

Background:
There is a possible relation between red blood cell distribution width
(RDW) and various clinical conditions. These conditions can render RDW disadvantageous in its
relation with cardiovascular disease. There may be a relation between the severity of acute
coronary syndrome (ACS) and the percentage of hypochromia (hypo%), percentage of
hyperchromia (hyper%), percentage of macrocytosis (MAC%), and percentage of microcytosis
(MIC%) values measured using new-generation hematological devices.

Objective:
We aimed to examine the relation between the SYNTAX score and the hypo%, hyper%,
MAC%, and MIC% values in patients admitted with ACS.

Method:
A group of 55 patients who underwent coronary angiography with diagnosis of ACS
(STEMI and NSTEMI) and a control group of 48 patients with normal coronary arteries were
included in the study. Venous blood samples were collected in the morning after a fasting of at
least 8 h and analyzed using standard laboratory methods. Hemogram parameters were studied
using Alinity HQ (Abbott, USA) a completely automated hemogram autoanalyzer. Biochemical
parameters were studied using Architect c16000 (Abbott, USA) a completely automated
biochemistry autoanalyzer.

Results:
Significant difference was observed in erythrocyte morphology-related tests (mean
corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration,
RDW, hypo%, hyper%, MIC%, and MAC%) between the groups. Correlation analysis showed a
positive correlation between the SYNTAX score and MAC% (r = 0.315, p = 0.019). Multivariate
logistic regression analysis was performed for MAC% to identify the independent predictors of the
SYNTAX score (β = 0.315, p = 0.019).

Conclusion:
Changes in MAC% test can be measured in emergencies with new-generation
hematological devices and used as independent predictors of the presence of severe coronary artery
disease.
Impact of COVID-19 Lockdown on Lethality of Suicide Cases
Authors: Almaghrebi Asma H. 
Published: May 2021

Background:
Studies show that the COVID-19 pandemic has promoted distress
and stress-related symptoms in the general population. It has also increased the suicide
rate in vulnerable groups who cannot handle the social and psychological consequences
of the pandemic and the measures in place to halt it.

Objective:
In this study, we compared the lethality of suicide attempts and the methods
chosen between the three months before the COVID-19 pandemic and three months during
curfew and lockdown in Saudi Arabia.

Methods:
This is a retrospective, causal-comparative study conducted at King Saud Medical
City in Riyadh, Saudi Arabia. A total of 62 suicide attempt cases between January
2020 and June 2020 were included in this study. The scale for assessment of the lethality
of suicide attempts (SALSA) was used for comparison, and cross-tabulation was used for
the data of suicide methods.

Results:
There was a significant difference (P = 0.003) in the total SALSA score before
and during the COVID-19 lockdown. The scores of the lethality of suicide attempts were
high during the lockdown. No significant difference was found in the suicide methods
selected between the two time periods. However, the use of psychotropic medication
overdose and self-immolation were prominent during the lockdown period.

Conclusions:
Our findings suggest that the lockdown during the COVID-19 pandemic is
likely associated with increased lethality of suicide attempts as well as an increased suicide
rate. The development of appropriate mental health services is required.
Long Non-coding RNAs in Heart Failure: A Deep Belief Network Based Cluster Analysis
Authors: Madhavan Manu , Gopalakrishnan Gopakumar 
Published: May 2021

Background:
Heart failure (HF) is a leading cause of mortality rate worldwide, but studied
less for its underlying biomolecular mechanisms. With the advances in gene sequence analysis,
many non-coding RNAs, especially from long non-coding RNA (lncRNA) genre are found to be
involved in regulating HF conditions. Recent studies are based on competing endogenous RNA
(ceRNA) theory in which lncRNA-miRNA-mRNA compounds control many disease conditions.

Method:
In this paper, we present a topic model based network cluster analysis to identify the role
of lncRNAs in HF. The network is constructed based on the differentially expressed long noncoding
RNAs (lncRNAs), micro RNAs (miRNAs), and messenger RNAs (mRNAs) of heart failure
patients and control samples from the gene expression omnibus (GEO) database. Further, we extend
the primary ceRNA network by adding pathways as additional nodes. Deep belief network
based feature learning is used to extract the features from the network automatically.

Results:
We obtained two clusters where each cluster was a mixture of lncRNAs, mRNAs, miRNAs
and pathways. The analysis included the identification of key lncRNAs, enriched pathways,
and gene ontology terms from each cluster. Based on the shreds of evidence from literature, one of
the clusters obtained was identified to be an essential functional module in HF mechanism. The potential
of lncRNA as a diagnostic biomarker in HF was also analysed.

Conclusion:
The proposed work gives more insight on involvement of lncRNAs in the HF mechanism.
The cluster analysis also brought some significant lncRNA-pathway associations into notice,
which are supported by recent literature. The identification of lncRNA biomarkers can help in the
early detection of HF and discover the missing links in disease pathology.
Detailed Chemistry Studies of 225Actinium Labeled Radiopharmaceuticals
Authors: Kilbas Benan , Eryilmaz Kurtulus 
Published: May 2021

Background:
The synthesis of 225Actinium derivatives was afforded by using PSMA-
617, DOTATATE peptides, and EDTMP ligand. Detailed experiments, quality control (QC),
and stability studies were also well described. The radiolabelling reactions were performed in mild
conditions with desirable radiochemical yields and high radiochemical purities.

Methods:
PSMA-617, DOTATATE were radiolabelled with 225Actinium in 0.1 M HCl in the presence
of ascorbate buffer solution and passed through the C-18 light cartridge for purification and
the product was eluted by ethanol-water solution. EDTMP was also radiolabelled with 225Actinium
without using any stabilizer and purification step. All products were well analyzed by R-TLC and
R-HPLC. The stability of those compounds was also studied within the validity period of time.

Results:
225Ac-DOTATATE and 225Ac-PSMA-617 were obtained at the same condition. The radiochemical
yield of 225Ac-DOTATATE was less than 225Ac-PSMA 617. The stability experiments indicating
decay daughters of 225Actinium appeared after T0 +1 h due to the recoil effect radiolysis.
On the other hand, 225Ac-EDTMP was more stable than DOTA-peptide radiolabelled compounds.
225Ac-EDTMP was produced with more than 95% radiochemical yield and 99% radiochemical purity.

Conclusion:
A detailed chemistry study was presented for the synthesis of 225Actinium derivatives
in mild conditions with absolute radiochemical purities and high yields. The experimental results
showed that 225Ac-EDTMP could be a suitable radiopharmaceutical alternative for bone metastases
arising from primer tumors as a cocktail therapy.
Pengaruh Edukasi Gizi terhadap Asupan dan Status Gizi Pasien Sirosis Hati
Authors: Mustika Syifa , Nurmalita Shafira , Samichah Samichah , Putri Fildzah Karunia , Sembiring Frinny , Ruliana Ruliana , Handayani Dian 
Published: May 2021

ABSTRAK Malnutrisi adalah masalah yang umum terjadi pada pasien sirosis hati. Kurangnya pengetahuan tentang gizi sehingga menyebabkan adanya pembatasan diet yang tidak perlu dan kemudian berkontribusi pada kejadian malnutrisi. Penelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian edukasi gizi terhadap status gizi dan asupan pasien sirosis hati di Poli Gastroenterohepatologi Rumah Sakit dr. Saiful Anwar Malang. Jenis penelitian yang dilakukan termasuk dalam penelitian experimental dengan desain penelitian pre-post test control group design. Kelompok intervensi adalah kelompok yang diberi edukasi gizi pada awal pengambilan data, sedangkan kelompok kontrol adalah kelompok yang tidak diberi edukasi gizi. Data yang diambil pada penelitian ini adalah data antropometri, data asupan saat pengambilan data awal dan akhir serta data asupan makan partisipan yang dimonitoring selama 1 bulan menggunakan food diary. Hasil penelitian ini menunjukkan tidak terdapatnya penurunan yang signifikan (p=0.48) pada Indeks Massa Tubuh partisipan di kelompok intervensi dan kontrol. Sedangkan asupan energi dan karbohidrat pada kelompok intervensi mengalami peningkatan yang signifikan (p<0.05). Pemberian edukasi akan memberikan efek positif dan efektif jika dilakukan bersama dengan peningkatan aktivitas fisik. Efek dari pemberian edukasi gizi akan nampak bila durasi monitoring dan evaluasi diperpanjang.Â Kata kunci: edukasi gizi, sirosis hati, status gizi, asupan zat gizi, antropometri giziABSTRACT Malnutrition is a common problem among liver cirrhosis patients. Lack of knowledge about nutrition causes unnecessary dietary restrictions and leads to the incidence of malnutrition. This study aimed to determine the effect of nutrition education on intake and nutritional status of patients with liver cirrhosis at the Gastroenterohepatology Department, dr. Saiful Anwar General Hospital, Malang. The design used was an experimental study with a pre-post test control group. The intervention group is the group given nutrition education, while the control group is the group without nutrition education. The data taken in this study were anthropometric, intake data when taking initial and final data, and participants' daily food intake monitored for a month using a food diary. The study results showed no significant decrease (p = 0.48) in the body mass index of participants in the intervention and control groups. However, the energy and carbohydrate intake in the intervention group experienced a significant increase (p <0.05). Providing nutrition education will have a positive and effective effect if done together with increased physical activity. The duration of monitoring and evaluation should be extended to see the effectiveness of the nutrition educationKeywords: nutritional education, liver cirrhosis, nutritional status, nutrient intake, nutritional anthropometry
User Perspectives on a Resilience-Building App (JoyPop): Qualitative Study
Authors: Mushquash Aislin R , Pearson Erin S , Waddington Kayla , MacIsaac Angela , Mohammed Shakira , Grassia Elizabeth , Smith Savanah , Wekerle Christine 
Published: May 2021

BackgroundResilience is the capability, resources, and processes that are available to a person or system to adapt successfully in the face of stress or adversity. Given that resilience can be enhanced, using advances in technology to deliver and evaluate the impact of resilience interventions is warranted. Evidence supports the effectiveness of the resilience-building JoyPop app in improving resilience-related outcomes after use; however, experiential data from users is also needed to provide a more comprehensive account of its utility.ObjectiveThe aim of this study was to explore users’ experiences with the JoyPop app and their perspectives on its utility.MethodsThis qualitative description study involved a combination of group and one-on-one semistructured interviews with a subset of first-year undergraduate students who participated in a larger evaluation of the JoyPop app. Participants used the app for a 4-week period and were subsequently asked about their frequency of app use, most and least used features (and associated reasons), most and least helpful features (and associated reasons), barriers to use, facilitators of use and continuation, and recommendations for improvement. Data were coded and categorized through inductive content analysis.ResultsThe sample of 30 participants included 24 females and 6 males, with a mean age of 18.77 years (SD 2.30). App use ranged from 1 to 5 times daily (mean 2.11, SD 0.74), with the majority indicating that they used the app at least twice daily. The Rate My Mood, Journal, and SquareMoves features were reported to be used most often, while the Rate My Mood, Journal, and Breathing Exercises features were identified as the most helpful. A number of themes and subthemes pertaining to facilitators of app use (prompts, creating routine, self-monitoring opportunities, expressive opportunities), barriers to app use (editing, lack of variety, student lifestyle), outcomes of app use (increased awareness, checking in with oneself, helpful distraction, emotional control), and recommendations for app improvement (adding more features, enhancing existing features, enhancing tracking abilities, providing personalization) were identified.ConclusionsThis study provides insight into the aspects of the JoyPop app that motivated and benefitted users, as well as measures that can be taken to improve user experiences and promote longer-term uptake. Users were willing to engage with the app and incorporate it into their routine, and they valued the ability to self-monitor, express emotion, and engage in distraction.
Evaluating Scholars’ Impact and Influence: Cross-sectional Study of the Correlation Between a Novel Social Media–Based Score and an Author-Level Citation Metric
Authors: Oliveira J e Silva Lucas , Maldonado Graciela , Brigham Tara , Mullan Aidan F , Utengen Audun , Cabrera Daniel 
Published: May 2021

Background
The development of an author-level complementary metric could play a role in the process of academic promotion through objective evaluation of scholars’ influence and impact.

Objective
The objective of this study was to evaluate the correlation between the Healthcare Social Graph (HSG) score, a novel social media influence and impact metric, and the h-index, a traditional author-level metric.

Methods
This was a cross-sectional study of health care stakeholders with a social media presence randomly sampled from the Symplur database in May 2020. We performed stratified random sampling to obtain a representative sample with all strata of HSG scores. We manually queried the h-index in two reference-based databases (Scopus and Google Scholar). Continuous features (HSG score and h-index) from the included profiles were summarized as the median and IQR. We calculated the Spearman correlation coefficients (ρ) to evaluate the correlation between the HSG scores and h-indexes obtained from Google Scholar and Scopus.

Results
A total of 286 (31.2%) of the 917 stakeholders had a Google Scholar h-index available. The median HSG score for these profiles was 61.1 (IQR 48.2), and the median h-index was 14.5 (IQR 26.0). For the 286 subjects with the HSG score and Google Scholar h-index available, the Spearman correlation coefficient ρ was 0.1979 (P<.001), indicating a weak positive correlation between these two metrics. A total of 715 (78%) of 917 stakeholders had a Scopus h-index available. The median HSG score for these profiles was 57.6 (IQR 46.4), and the median h-index was 7 (IQR 16). For the 715 subjects with the HSG score and Scopus h-index available, ρ was 0.2173 (P<.001), also indicating a weak positive correlation.

Conclusions
We found a weak positive correlation between a novel author-level complementary metric and the h-index. More than a chiasm between traditional citation metrics and novel social media–based metrics, our findings point toward a bridge between the two domains.
A Multimodal Imaging–Based Deep Learning Model for Detecting Treatment-Requiring Retinal Vascular Diseases: Model Development and Validation Study
Authors: Kang Eugene Yu-Chuan , Yeung Ling , Lee Yi-Lun , Wu Cheng-Hsiu , Peng Shu-Yen , Chen Yueh-Peng , Gao Quan-Ze , Lin Chihung , Kuo Chang-Fu , Lai Chi-Chun 
Published: May 2021

Background
Retinal vascular diseases, including diabetic macular edema (DME), neovascular age-related macular degeneration (nAMD), myopic choroidal neovascularization (mCNV), and branch and central retinal vein occlusion (BRVO/CRVO), are considered vision-threatening eye diseases. However, accurate diagnosis depends on multimodal imaging and the expertise of retinal ophthalmologists.

Objective
The aim of this study was to develop a deep learning model to detect treatment-requiring retinal vascular diseases using multimodal imaging.

Methods
This retrospective study enrolled participants with multimodal ophthalmic imaging data from 3 hospitals in Taiwan from 2013 to 2019. Eye-related images were used, including those obtained through retinal fundus photography, optical coherence tomography (OCT), and fluorescein angiography with or without indocyanine green angiography (FA/ICGA). A deep learning model was constructed for detecting DME, nAMD, mCNV, BRVO, and CRVO and identifying treatment-requiring diseases. Model performance was evaluated and is presented as the area under the curve (AUC) for each receiver operating characteristic curve.

Results
A total of 2992 eyes of 2185 patients were studied, with 239, 1209, 1008, 211, 189, and 136 eyes in the control, DME, nAMD, mCNV, BRVO, and CRVO groups, respectively. Among them, 1898 eyes required treatment. The eyes were divided into training, validation, and testing groups in a 5:1:1 ratio. In total, 5117 retinal fundus photos, 9316 OCT images, and 20,922 FA/ICGA images were used. The AUCs for detecting mCNV, DME, nAMD, BRVO, and CRVO were 0.996, 0.995, 0.990, 0.959, and 0.988, respectively. The AUC for detecting treatment-requiring diseases was 0.969. From the heat maps, we observed that the model could identify retinal vascular diseases.

Conclusions
Our study developed a deep learning model to detect retinal diseases using multimodal ophthalmic imaging. Furthermore, the model demonstrated good performance in detecting treatment-requiring retinal diseases.
Recent studies of synthetic antibody-based 3-MCPD determination technology
Authors: MUNAWAR Hasim , LUNA Prima , KRESNAWATY Irma , WIDIASTUTI Happy 
Published: May 2021

3-Chloro-1,2-propanediol (3-MCPD) is classified by the International Agency for Research on Cancer as carcinogenic material. 3-MCPD will also become one of the European Union's requirements, proposing the maximum level of the 3-MCPD in palm oil until 2.5 ppm. Although the reported technologies GCMS and HPLC-FLD demonstrated high sensitivity and selectivity on 3-MCPD determination, those technologies invest in chemical and time-consuming sample preparation and analysis. Molecularly imprinted polymer (MIP), or a synthetic antibody, can be used to recognize 3-MCPD. MIP is more robust under extreme environments such as temperature and pH. This paper, therefore, aims to discuss the application of MIP on sample extraction and analysis to detect 3-MCPD. MIP is synthesized by polymerization of functional monomers surrounding 3-MCPD as a template. 3-MCPD is then removed from the MIP, leaving active cavities. Thus, these sites can either covalently or non-covalently rebind to 3-MCPD. Computational or empirical studies could investigate the composition of MIP. MIP can be manufactured as MIP-based solid phase extraction (MIPSPE) and MIP-based sensor. Both applications showed significant analytical parameters, such as recovery higher than 90% and detection limit lower than 2.5 ppm. Therefore, the application of MIP can be flexible for sample preparation and analysis on the 3-MCPD determination. MIP-based technology would be a prospective instrument to detect 3-MCPD. In the future, producing MIP on an industrial scale will be a challenge to monitor the 3-MCPD level in palm oil.
The role of calcium in drought stress response induced through antioxidant activity in oil palm (Elaeis guineensis Jacq.) seedlings
Authors: NURWAHYUNI Endah , PUTRA Eka Tarwaca Susila 
Published: May 2021

Oil palm productivity in Indonesia faces challenges related to drought that occur during the dry season. Calcium is an element that plays a role in determining the response of plant resistance to drought through biochemical activity. This study aims to determine the contribution of calcium in biochemical mechanisms involving various antioxidants. The treatment was arranged in factorial of 3 x 4 in a split-plot design. The first factor was calcium dosage, which consisted of 0 g (control/without calcium), 0.04 g, 0.08 g, and 0.12 g of calcium per plant. The second factor was the intensity of drought stress, referred as the Fraction of Transpirable Soil Water (FTSW) at 1 (control/field capacity), 0.35 (moderate drought), and 0.15 (severe drought) with a week duration of intensity. Calcium was applied in a ring placement on four-month-old seedlings planted in 40 x 40 cm polybags with alfisol soil planting medium and given drought treatment two months later for three weeks. The results showed that calcium could induce plant response to drought through the increase in superoxide dismutase (SOD) activity, the decrease in hydrogen peroxide (H₂O₂) concentration, and the decrease in malondialdehyde (MDA) concentration. The study concluded that calcium is an essential element used to reduce the effects of drought on oil palm seedlings through the change of biochemical activities regulated by enzymatic antioxidants.