bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiparametric MRI and 18F-DCFPyL PET/CT for detection of locally recurrent prostate cancer after low dose rate brachytherapy
Authors: Walker Stephanie M. , Fernandez Martina , Roy Soumyajit , Mena Esther , Sackett Jonathan , Mease Ronnie , Merino Maria , Pomper Martin , Salerno Kilian , Schott Erica , Wood Bradford , Pinto Peter , Lindenberg Liza , Choyke Peter , Citrin Deborah , Turkbey Baris 
Published: March 2021

Abstract
Background and purpose: Both multiparametric magnetic resonance imaging (mpMRI) and prostate specific membrane antigen (PSMA)-targeting positron emission tomography (PET) imaging have shown promise in early localization of prostate cancer (PCa) recurrence after primary external beam radiotherapy. Detecting recurrence after brachytherapy for PCa using MRI is significantly hampered by susceptibility artifacts secondary to brachy seeds. Here, we compare the efficacy of 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT versus mpMRI for detecting sites of local recurrence after low dose rate (LDR) brachytherapy for prostate cancer.Materials and methods: A total of 155 patients with a history of recurrent PCa who underwent mpMRI at 3 Tesla and 18F-DCFPyL PET/CT were retrospectively reviewed. Patients who underwent LDR brachytherapy for PCa and had subsequent biochemical recurrence (BCR) followed by mpMRI and 18F-DCFPyL PET/CT were included in this study. mpMRI was performed on a 3T scanner with endorectal and surface coils and images were prospectively read by a single expert radiologist. The 18F-DCFPyL PET/CT scan was prospectively interpreted by two nuclear medicine physicians. Patients underwent targeted biopsy when deemed clinically necessary and specimens were interpreted by an expert GU pathologist. Positivity rates (PR) from mpMRI and 18F-DCFPyL PET/CT were compared, and pathology results were used to calculate the positive predictive value (PPV) of each imaging modality for detecting PCa recurrence.Results: 15 patients who underwent LDR brachytherapy and had subsequent biochemical failure were imaged with mpMRI and 18F-DCFPyL PET/CT. 18 non-lymph node lesions were identified on at least one imaging modality. The PR for detection of intraprostatic lesions was 60% (9/15) for both PET/CT and mpMRI, with 3 prostate lesions detected by only one modality. 18F-DCFPyL PET/CT identified pelvic and extra-pelvic lymph nodes in 8 (53%) patients, while mpMRI noted positive lymph node findings in only 2 (13%) patients. A total of 15 lesions corresponding to 9 patients were targeted for biopsy. The PPV of 18F-DCFPyL PET/CT and mpMRI for the detection of local recurrence were 84.6% and 71.4%, respectively. For the detection of intraprostatic lesions, 18F-DCFPyL PET/CT and mpMRI had a PPV of 87.5% and 71.4%, respectively. Conclusion: This case series analysis suggests that 18F-DCFPyL PET/CT may detect local and regional recurrent PCa after LDR brachytherapy at a higher rate than mpMRI and that it has the potential to detect suspicious pelvic lymph nodes at a much higher rate. Further studies are needed to validate these findings in larger cohorts.
Investigation of in Vitro Culturing Method for Ascaris lumbricoides Eggs in Laboratory: From Soil to Bench.
Authors: Nisha Mehru , Ghozi Athira Mohd , Davamani Fabian 
Published: March 2021

Abstract
Objective: Ascaris lumbricoides eggs are naturally available in contaminated soil and embryonated eggs are the source of Ascariasis infection to human. Investigation of in vitro culturing of Ascaris eggs in laboratory in not routinely reported in the literature. Hence, this study was carried out to investigate a simple method on in vitro culturing method for Ascaris lumbricoides eggs isolated from soil samples from an indigenous village in Malaysia.Results: Four stages of Ascaris lumbricoides eggs from the first-cell stage until the fourth stage were obtained. At the embryonation stage, the larvae of Ascaris worm was observed indicating survival of the eggs under an acidic environment.
Basilaphelenchus hyrcanus n. sp. (Rhabditida: Tylaphelenchinae) associated with bark of a beech tree (Fagus orientalis Lipsky) from northern Iran
Authors: Golhasan Behrouz , Miraeiz Esmaeil , Tanha maafi Zahra , Heydari Ramin 
Published: March 2021

Abstract

Basilaphelenchus hyrcanus n. sp., the sixth species of the newly established genus was isolated during a nematode survey associated with bark samples of beech tree in northern Iran, which differs from the other species by body size, stylet length, metacorpus structure, and tail characters of both genders. The new species is also characterized by elevated cephalic region with sclerotised vestibule, posteriorly directed stylet knobs, well-developed metacorpus filling corresponding body region, position of excretory pore at the level of base of metacarpus, length of post uterine sac by 38–60 μm long, conoid elongate tail by sharp to finely rounded tip in female. Based upon the morphological characteristics and phylogenetic analyses of partial 18 S and D2-D3 28 S rDNA segments, the new species mostly resembles B. magnabulbus. However, B. hyrcanus n. sp. is clearly different from this species by having a longer stylet, different position of the excretory pore, a different male tail tip characters and 4.4 and 13.2% sequence divergences in 18 S and D2-D3 28 S, respectively.
Retos del profesor universitario: un rol que se re-configura permanentemente
Authors: Martínez Delgado Cecilia María , Mejía Pérez Paula Natalia , Bano Jaramillo Iván David , Echeverri Escobar José Ignacio , Vélez Jaramillo Luis Fernando , Vélez Ríos Julián Emilio , Restrepo Restrepo Manuel 
Published: March 2021

La profesión docente constituye un desafío permanente para quienes la ejercemos, debido a que socialmente es una de las profesiones menos valoradas. Sin embargo, en ella recae la obligación de formar los ciudadanos del futuro, en cualquiera de las épocas en las que se ejerza. Se presenta una aproximación al deber ser del profesor universitario, teniendo en cuenta que se configura y re-configura en una labor de importancia, asociada a la calidad educativa. Se plantean no solo valores que se deben tener para este ejercicio, sino también los retos que el mundo actual en constante cambio le asigna, para la formación integral de los futuros profesionales. Esta reflexión se realizó a partir de conversaciones académicas de algunos integrantes de la comunidad educativa de un área de la salud.
Does Innovation Affect Company Performance? Exploring the Mediation Effects of Management Accounting Information Systems
Authors: Miftah Desrir , Julina  
Published: March 2021

This study attempt to determine the direct effect of innovation on company performance and its indirect effect through Management Accounting Information Systems (MAIS) as an mediating/intervening variable. Samples were managers in the manufacturing industry that produces Crude Palm Oil (CPO) operating in Riau Province. Data collected through questionnaires and processed using SEM-PLS. The results found that innovation affects firm performance. Management Accounting Information Systems mediates the effect of innovation and firm performance. Research on MAIS as intervening variable in the palm oil industry was first carried out especially in Indonesia. Innovations made by company through a good Management Accounting Information System will improve the performance of CPO producing company
Climate change and water insecurity in rural uMkhanyakude District Municipality: an assessment of coping strategies for rural South Africa
Authors: Patrick Hosea Olayiwola 
Published: March 2021

Abstract
The vulnerability of Africa to climate change extremes and eventual impacts is extremely high due to the weak coping strategies prevalent in the continent. The peculiarity of South Africa to these vulnerabilities, especially for water security, is an issue of socioeconomic and policy issue. Based on the premises of human security, the study assesses the coping strategies of rural communities in South Africa, focusing on uMkhanyakude District Municipality, KwaZulu-Natal province, given the effects of climate change-induced water scarcity on the area. The study employed a multilayered descriptive mixed method triangulation approach. It focused specifically on the connection between water and climate change and the adopted everyday vertical and horizontal coping strategies. The findings revealed a strong correlation between the behavioral and traditional coping strategies in the study area, water depletion/scarcity, and climate change. It also showed that government institutions are reactionary in their response to climate change-induced impacts. The study, therefore, recommends a pre-resilience mechanism that makes institutions and individuals proactive rather than adopting a reactionary post-resilience strategy in response to the effects of climate change-induced water security.
Assessment of basin-wise future agricultural drought status across India under changing climate
Authors: Suman Mayank , Maity Rajib 
Published: March 2021

AbstractMost of the existing studies on meteorological drought suggest more intense and frequent drought events due to changing climate. However, basin-scale assessment of future agricultural drought is lacking due to many reasons. In this study, the intensity and frequency of future agricultural drought (characterized by the Standardized Soil Moisture Index, SSMI) for 226 sub-basins across India are analyzed, and vulnerable basins are identified. The prediction of the future agricultural drought status is achieved using the wavelet-based drought temporal consequence modeling of meteorological drought with the best performing bias-corrected Coordinated Regional Downscaling Experiment (CORDEX) simulations, selected by Multi-Criteria Decision-Making frameworks. This study reveals a geographically contrasting change in future agricultural drought that indicates more intense agricultural drought in north, north-east, and central India as compared with south India. The area under drought is also expected to increase, and about 20 and 50% of the Indian mainland is expected to suffer from extreme (SSMI ≤ −2) and moderate (SSMI ≤ −1) agricultural drought conditions by the end of this century. Sub-basins lying in north and central India are expected to have a longer time under drought conditions. Thus, the findings of this study will be useful for future planning and preparedness against agricultural productivity.
Parameters optimization for eutrophic lake water treatment by a novel process of iron-carbon micro-electrolysis coupled with catalytic ozonation using response surface methodology
Authors: Jiang Shanqing , Cao Yu , Han Pei , Zhang Yanan , Zhang Hankun , Zhang Qiuya , Xu Xia , Zhou Yuanyuan , Wang Liping 
Published: March 2021

Abstract
A novel process of iron-carbon micro-electrolysis (ICME) coupled with catalytic ozonation (CO) for treatment of eutrophic lake water was developed. A series of batch experiments with ICME alone and CO alone was designed to investigate the effects of process parameters, such as initial pH, dose of Fe-C, time of micro-electrolysis, ozone flux, dose of TiO2/activated carbon (TiO2/AC), and time of ozonation, on the removal rates of total nitrogen (TN), total phosphorus (TP), CODMn and Chl-a. The process parameters were optimized using response surface methodology. The results showed that initial pH, dose of Fe-C and ozone flux had significant effects on removal of TN, TP, CODMn and Chl-a. Within the range of selected operating conditions, the optimized values of initial pH, dose of Fe-C, time of micro-electrolysis, ozone flux, dose of TiO2/AC, and time of ozonation were 3.8, 13.7 g/L, 29.6 min, 3.19 L/min, 294.74 mg/L and 106.73 min, respectively. Furthermore, ICME alone had significant advantages in TP and CODMn removal and CO alone favored TN and Chl-a. Under the optimal process conditions, the final removal rates of TN, TP, CODMn, and Chl-a by the hybrid ICME-CO process reached 75.33%, 86.29%, 94.42% and 97.57%, respectively. The present research provides a new alternative technology with promise for treatment of eutrophic lake water.
Characteristics of the extracellular products of pure oxygen aerated activated sludge in batch mode
Authors: He Jia-Ying , Zhang Hong-Ling , Wang Hong , Hu Ya-Qi , Zhang Yong 
Published: March 2021

Abstract
The effects of pure oxygen aeration on compositional characteristics of soluble microbial products (SMP) and extracellular polymeric substances (EPS) of the activated sludge acclimated in a sequential batch reactor (SBR) were explored in batch mode. The structure of the extracellular products would change with different aeration methods or aeration rates. The proportion of SMP of most oxygen aerated sludge was less than 10%, while that in air aerated sludge was as high as 30–40%. The proportion of TB-EPS decreased from 56.95% to 30.63%, and the proportion of LB-EPS increased obviously with the increase of oxygen aeration rate. The contents of the protein (PN) and the polysaccharide (PS) of extracellular products with oxygen aeration were significantly different, and the PN was much higher than PS (p &lt; 0.05). The zeta potential of each component in activated sludge was negative, gradually decreasing with the progress of biological treatment. The fluorescence peaks in SMP, LB-EPS and TB-EPS with pure oxygen aeration were attributed to tryptophan PN-like and humic acid-like fractions. The results showed that the proportion of the components in the extracellular products could be regulated by adjusting the aeration rate and aeration mode, so as to optimize the treatment process of activated sludge.
Novel Study Designs in Precision Medicine – Basket, Umbrella and Platform
Trials
Authors: Kesari Harshad V. , Ravi Renju 
Published: March 2021

:
The concept of ‘one size fits all’ - one treatment for patients with a particular disease,
seems to be outdated. The advent of precision medicine has prompted profound changes in clinical
research and it allows researchers to predict more accurately, the prevention and treatment strategies
for a specific disease population. Novel study designs are, therefore, essential to establish safe
and effective personalized medicine. Basket, umbrella and platform trial designs (collectively referred
to as master protocols) are biomarker enrichment designs that allow for testing more than
one hypotheses within a protocol, thus accelerating drug development. These trial designs tailor intervention
strategies based on patient’s risk factor(s) that can help predict whether they will respond
to a specific treatment. Basket trials evaluate therapy for various diseases that share a common
molecular alteration, while umbrella trials evaluate multiple targeted therapies for a single disease
that is stratified into subgroups based on different molecular alterations/ risk factors. These designs
are complex and their major limitations stem from the fact that it would be inappropriate to
completely replace histological typing with molecular profiling alone. However, in the upcoming
decades, these trial designs are likely to gain popularity and improve the efficiency of clinical research.
This article briefly overviews the characteristics of master protocol designs with examples
of completed and ongoing clinical trials utilizing these study designs.
Konsep Pendidikan Islam Holistik Prof. Dr. Tuty Alawiyah serta relevansinya di Era Millenium
Authors: Ulya Amaliy Atul , Ulya Amaliy Atul 
Published: March 2021

<p><em>Prof. Dr. Tuty Awawiyah is a female scholar as well as educational thinker who succeded establishing and managing Pesantren-based schools starting form kindergarten, the elementary school, junior high school, the senior high school until the college. The Purpose of this paper is to add insight and treasure about the concept of holistic Islamic education of Prof. Dr. Tuty Alawiyah and its relevance in the Millenium Era. Based on reseach and literature review that have been done, Islamic holistic education can be interpreted as education that is able to answer the problems of education faced in the word of education di the millennium era, for Islamic holistic education is education that shapes something in a whole way, therefore it becomes a very large unity that any other exithing combination. In can be concluded that, some holictic Islamic Education concept form Prof. Dr Tuty Alawiyah are very relevant so it needs to be discussed and they will appropriate as a quide in the millennium Era. </em></p><p><em> Keyword: Tuty Alawiyah, Education, Millennium Era.</em></p>
WeChat as a Platform for Problem-Based Learning Among Hematological Postgraduates: Feasibility and Acceptability Study
Authors: Luo Ping , Pang Wenwen , Wang Yingying , Liu Minghui , Zhou Shu , Liu Shuai , Zhang Xian , Liu Li , Liu Yanan , Zhou Fuling 
Published: March 2021

Background
Hematological medicine is a practical discipline that is difficult to study. Problem-based learning (PBL) is an innovative student-centered teaching method wherein students define their own learning objectives from clinically based problems. Considering that WeChat is the most popular communication app in China, we selected it as a new platform for online PBL to reduce the limitations of traditional PBL in hematology teaching.

Objective
This study aims to explore a new pedagogical method called WeChat-PBL, which is based on real micro clinical cases for postgraduates majoring in hematology and to demonstrate its feasibility and acceptability.

Methods
A total of 48 hematological postgraduates and 7 tutors participated in this study. We divided the participants into 7 groups where students can learn theoretical knowledge. After each course, the members of each group were required to complete in-class quizzes. Moreover, the students and tutors were required to fill out periodic (after each class) and overall (after each semester) evaluations.

Results
A total of 8 micro clinical cases were presented in WeChat-PBL. The average quiz score for acute myelogenous leukemia, chronic myeloid leukemia, multiple myeloma, acute promyelocytic leukemia, and lymphoma were 89.0%, 86.0%, 83.4%, 88.8%, and 77.5%, respectively. Periodic evaluations showed that both students and tutors were satisfied with the process of WeChat-PBL. The overall evaluation results showed that WeChat-PBL was able to positively impact the learning experiences of hematological postgraduates.

Conclusions
Our results indicate the feasibility and acceptability of the WeChat-PBL teaching method for postgraduates majoring in hematology.
Emotional Reactions to Cybersecurity Breach Situations: Scenario-Based Survey Study
Authors: Budimir Sanja , Fontaine Johnny R J , Huijts Nicole M A , Haans Antal , Loukas George , Roesch Etienne B 
Published: March 2021

BackgroundWith the ever-expanding interconnectedness of the internet and especially with the recent development of the Internet of Things, people are increasingly at risk for cybersecurity breaches that can have far-reaching consequences for their personal and professional lives, with psychological and mental health ramifications.ObjectiveWe aimed to identify the dimensional structure of emotion processes triggered by one of the most emblematic scenarios of cybersecurity breach, the hacking of one’s smart security camera, and explore which personality characteristics systematically relate to these emotion dimensions.MethodsA total of 902 participants from the United Kingdom and the Netherlands reported their emotion processes triggered by a cybersecurity breach scenario. Moreover, they reported on their Big Five personality traits, as well as on key indicators for resilient, overcontrolling (internalizing problems), and undercontrolling (aggression) personality types.ResultsPrincipal component analyses revealed a clear 3-dimensional structure of emotion processes: emotional intensity, proactive versus fight/flight reactions, and affective versus cognitive/motivational reactions. Regression analyses revealed that more internalizing problems (β=.33, P<.001), resilience (β=.22, P<.001), and agreeableness (β=.12, P<.001) and less emotional stability (β=–.25, P<.001) have significant predictive value for higher emotional intensity. More internalizing problems (β=.26, P<.001), aggression (β=.25, P<.001), and extraversion (β=.07, P=.01) and less resilience (β=–.19, P<.001), agreeableness (β=–.34, P<.001), consciousness (β=–.19, P<.001), and openness (β=–.22, P<.001) have significant predictive value for comparatively more fight/flight than proactive reactions. Less internalizing problems (β=–.32, P<.001) and more emotional stability (β=.14, P<.001) and aggression (β=.13, P<.001) have significant predictive value for a comparatively higher salience for cognitive/motivational than affective reactions.ConclusionsTo adequately describe the emotion processes triggered by a cybersecurity breach, two more dimensions are needed over and above the general negative affectivity dimension. This multidimensional structure is further supported by the differential relationships of the emotion dimensions with personality characteristics. The discovered emotion structure could be used for consistent predictions about who is at risk to develop long-term mental well-being issues due to a cybersecurity breach experience.
HPLC Method Development and Validation for the Estimation of Amlodipine and Atorvastatin in Bulk and Formulation
Authors: Vishwakarma Ranu , Bhadoriya Santosh Singh , Loksh Kavita R. 
Published: March 2021

In the present research work, a successful attempt was made for Validated UV and HPLC method development for the estimation of Amlodipine and Atorvastatin in marketed formulation which was developed by experimentation based on thorough literature survey and ascertained by statistical parameters of sampling. The simplicity, rapidity, accurate and reproducibility of the proposed methods completely fulfill the objective of the research work of estimation of the drug in marketed formulation. Liquid chromatographic system from waters comprising of manual injector, Waters 515 binary pump for constant flow and constant pressure delivery and U.V. detector connected to data ace software controlling the instrumentation as well as processing the data generated were used. The isocratic mobile phase consisted of 20 mM KH2PO4: Acetonitrile (pH 3 with OPA) in the ratio of 20:80 v/v at a flow rate of 1.0 ml min-1. A thermo C-18 column (4.6 x 250mm, 5μ particle size) was used as the stationary phase, 237.0 nm was selected as the detection wavelength for UV-vis. detector. The proposed methods were found to be linear in the range of 1-5 μg/ml & 5-25 μg/ml with correlation coefficient close to one for amlodipine and atorvastatin respectively. Precision was determined by repeatability, Intermediate precision and reproducibility of the drugs. The robustness of developed method was checked by changing in the deliberate variation in solvent. The Simplicity, Rapidly and Reproducibility of the proposed method completely fulfill the objective of this research work.
Keywords: Amlodipine, Atorvastatin, Method development, HPLC, Validation
A CORRUPÇÃO ENQUANTO FENÔMENO SOCIAL: ELEMENTO PERNICIOSO NAS ESTRUTURAS ESTATAIS OU GRAXA SOBRE AS RODAS DA ECONOMIA?
Authors: GOMES ALVES DIEGO 
Published: March 2021

Diversos estudos procuram entender a corrupção, desde sua origem até suas formas de repressão. Este ensaio, entretanto, buscará fugir do usual e pesquisar se, de alguma forma, a corrupção pode ajudar a impulsionar o crescimento de economias engessadas por burocratizações excessivas, regulamentações paralisantes e instituições com baixa efetividade.
Sobre o tema, serão analisadas duas teorias econômicas antagônicas (teoria da graxa sobre rodas X teoria da areia sobre rodas), bem como os diversos autores que as sustentam, ainda que de forma indireta, em seus estudos.