bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shallow Crustal Shear Velocity and Vp/Vs Across Southern California: Joint Inversion of Short‐Period Rayleigh Wave Ellipticity, Phase Velocity, and Teleseismic Receiver Functions
Authors: Berg Elizabeth M. , Lin Fan‐Chi , Schulte‐Pelkum Vera , Allam Amir , Qiu Hongrui , Gkogkas Konstantinos 
Published: July 2021

AbstractNear‐surface seismic velocity structure plays a critical role in ground motion amplification during large earthquakes. In particular, the local Vp/Vs ratio strongly influences the amplitude of Rayleigh waves. Previous studies have separately imaged 3D seismic velocity and Vp/Vs ratio at seismogenic depth, but lack regional coverage and/or fail to constrain the shallowest structure. Here, we combine three datasets with complementary sensitivity in a Bayesian joint inversion for shallow crustal shear velocity and near‐surface Vp/Vs ratio across Southern California. Receiver functions–including with an apparent delayed initial peak in sedimentary basins, and long considered a nuisance in receiver function imaging studies–highly correlate with short‐period Rayleigh wave ellipticity measurements and require the inclusion of a Vp/Vs parameter. The updated model includes near‐surface low shear velocity more in line with geotechnical layer estimates, and generally lower than expected Vp/Vs outside the basins suggesting widespread shallow fracturing and/or groundwater undersaturation.
Inferring the Shallow Layered Structure at the Chang’E‐4 Landing Site: A Novel Interpretation Approach Using Lunar Penetrating Radar
Authors: Giannakis Iraklis , Zhou Feng , Warren Craig , Giannopoulos Antonios 
Published: July 2021

AbstractThe current paper investigates the shallow layers of the lunar regolith at the Chang’E‐4 landing site. Four layers between 0 and 10 m were identified using lunar penetrating radar. Based on these outputs, a revised stratigraphic model is suggested for the post‐Imbrian ejecta at the Von Kármán crater. The layers were previously unseen due to the smooth boundaries between them. The revised model was inferred using an advanced hyperbola‐fitting scheme. Applying conventional hyperbola‐fitting to non‐homogeneous media results in errors and inaccuracies that are often wrongly assumed to be negligible. We propose a novel hyperbola‐fitting scheme that is, not constrained to homogeneous media and can be applied subject to any arbitrary one‐dimensional permittivity distribution. Via this approach, we can estimate the permittivity profile of an investigated area and detect layered structures that were previously transparent to electromagnetic waves due to the gradational dielectric properties at their interfaces.
On the Generation of Pi2 Pulsations due to Plasma Flow Patterns Around Magnetosheath Jets
Authors: Katsavrias C. , Raptis S. , Daglis I. A. , Karlsson T. , Georgiou M. , Balasis G. 
Published: July 2021

AbstractWe report observations of a magnetosheath jet followed by a period of decelerated background plasma. During this period, THEMIS‐A magnetometer showed abrupt disturbances which, in the wavelet spectrum, appeared as prominent and irregular pulsations in two frequency bands (7.6–9.2 and 12–17 mHz) within the Pi2 range. The observations suggest—for the first time to our knowledge—that these pulsations were locally generated by the abrupt magnetic field changes driven by the jet’s interaction with the ambient magnetosheath plasma. Furthermore, similar pulsations, detected by THEMIS‐D inside the magnetosphere with a 140 s time‐lag (which corresponds to the propagation time of a disturbance traveling with Alfvénic speed), are shown to be directly associated with the ones in the magnetosheath, which raises the question of how exactly these pulsations are propagated through the magnetopause.
Linking Large‐Scale Circulation Descriptors to Precipitation Variability in the Northern French Alps
Authors: Blanc Antoine , Blanchet Juliette , Creutin Jean‐Dominique 
Published: July 2021

AbstractThis work analyses the link between Western Europe large‐scale circulation and precipitation variability in the Northern French Alps from 1950 to 2017. We consider simple descriptors characterizing the daily 500 hPa geopotential height fields. They are the maximum pressure difference (MPD)—representing the range of geopotential heights over Western Europe, and the singularity—representing the mean distance between a geopotential shape and its closest analogs, that is, the way this geopotential shape is reproduced in climatology. We show that the MPD and the singularity of geopotential shapes explain a significant part of precipitation variability in the Isère River catchment () from 10 days to 10 years, especially in winter (correlations of 0.7). These simple descriptors ‐ that are easy to implement—provide as much information as weather pattern classification and much better performance than North Atlantic Oscillation to explain precipitation variability over a medium size mountainous catchment.
Aquifer Permeability Decreases Before Local Earthquakes Inferred From Water Level Response to Period Loading
Authors: Sun Xiaolong , Xiang Yang 
Published: July 2021

AbstractChanges of permeability caused by dynamic stress induced by distant earthquakes have been widely reported. Permeability decreases before local earthquakes have been less commonly reported. In this study, we document pre‐earthquake aquifer permeability decreases in a well named X11 in northwest China. The response of the water level to barometric pressure and Earth tides was used to calculate relative changes in permeability between July 2014 and February 2020. The results revealed that there was a decrease in the permeability of the aquifer prior to four local earthquakes between 2015 and 2020. We infer that crack clogging caused by particle deposition causes the permeability decreases before earthquakes.
Stratigraphic Evidence for Early Martian Explosive Volcanism in Arabia Terra
Authors: Whelley Patrick , Matiella Novak Alexandra , Richardson Jacob , Bleacher Jacob , Mach Kelsey , Smith Reagan N. 
Published: July 2021

AbstractSeveral large paterae in Arabia Terra are suggested to be calderas that produced colossal explosive eruptions (i.e., supereruptions). If these features are indeed explosive calderas, dispersion modeling suggests extensive ash deposits should be common throughout the region. However, such deposits have not previously been linked with the suggested calderas. Here, we describe layered deposits containing minerals both consistent with and diagnostic of altered volcanic ash throughout Arabia Terra. These deposits include Al‐dominant minerals such as montmorillonite, imogolite, and allophane among others. Altered ash deposits are found to thin (from 1‐km to 100‐m thickness) away from the suggested calderas. We estimate that the volcanic ash observed in Arabia Terra is the result of between 1,000 and 2,000 individual explosive eruptions over 500‐million years. Our observations support the hypothesis that Arabia Terra hosted supereruptions in the late Noachian‐early Hesperian that repeatedly blanketed the region with layers of ash.
Reorganized Atmospheric Circulation During the Little Ice Age Leads to Rapid Southern California Deoxygenation
Authors: Wang Yi , Hendy Ingrid L. 
Published: July 2021

AbstractThe magnitude of natural oceanic dissolved oxygen (DO) variability remains poorly understood due to the short duration of the observational record. Here we present a high‐resolution (4–9 years) reconstruction of the Southern California oxygen minimum zone (OMZ) through the Common Era using redox‐sensitive metals. Rapid OMZ intensification on multidecadal timescales reveals greater DO variability than observed in instrumental records. An anomalous interval of intensified OMZ between 1600–1750 CE contradicts the expectation of better‐ventilated mid‐depth North Pacific during cool climates. Although the influence of low‐DO Equatorial Pacific Intermediate Water on the Southern California Margin was likely weaker during this interval, we attribute the observed rapid deoxygenation to reduced North Pacific Intermediate Water (NPIW) ventilation. NPIW ventilation thus appears very sensitive to atmospheric circulation reorganization (e.g., a weakened Siberian High and Aleutian Low). In addition to temperature‐induced gas solubility, atmospheric forcing under future anthropogenic influences could amplify OMZ variability.
The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA–RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis
Authors: Li Dandan , She Jiajun , Hu Xinhui , Zhang Meixin , Sun Ruonan , Qin Shanshan 
Published: July 2021

AbstractLncRNAs play essential roles in tumorigenesis and tumor progression. Pseudogene UBE2CP3 is an antisense intronic lncRNA. However, the biological function of UBE2CP3 in gastric cancer (GC) remains unknown. In this study, we revealed that lncRNA UBE2CP3 was aberrantly upregulated in multiple independent gastric cancer cohorts, and its overexpression was clinically associated with poor prognosis in GC. UBE2CP3 was mainly located in cytoplasm and promoted migratory and invasive capacities of GC cells in vitro and in vivo. Mechanismly, a novel dysregulated ceRNA network UB2CP3/miR-138-5p/ITGA2 was identified in GC by transcriptome sequencing. Furthermore, rescue assay further confirmed that UBE2CP3 mainly promoted GC progression through miR-138-5p/ITGA2 axis. More importantly, our data proved that UBE2CP3/IGFBP7 could form an RNA duplex, thereby directly interacting with the ILF3 protein. In turn, this RNA-RNA interaction between IGFBP7 mRNA and UBE2CP3 mediated by ILF3 protein plays an essential role in protecting the mRNA stability of UBE2CP3. In addition, transcription factor ELF3 was identified to be a direct repressor of lncRNA UBE2CP3 in GC. Taken together, overexpression of UBE2CP3 promotes tumor progression via cascade amplification of ITGA2 upregulation in GC. Our finding has revealed that the dysregulation of UBE2CP3 is probably due to the downregulation of ELF3 and/or the overexpression of IGFBP7 mRNA in GC. Our findings reveal, for the first time, that UBE2CP3 plays crucial a role in GC progression by modulating miR-138-5p/ITGA2 axis, suggesting that UBE2CP3 may serve as a potential therapeutic target in GC.
Articaine in dentistry: an overview of the evidence and meta-analysis of the latest randomised controlled trials on articaine safety and efficacy compared to lidocaine for routine dental treatment
Authors: Martin Erica , Nimmo Alan , Lee Andrew , Jennings Ernest 
Published: July 2021

AbstractObjectivesTo comprehensively review the existing studies of articaine in dentistry and conduct a systematic review and meta-analysis to answer the following Population, Intervention, Comparison and Outcome question: “Is articaine a safe and efficacious local anaesthetic for routine dental treatment compared to lidocaine?”MethodsDatabase searches were conducted in Medline Ovid, Medline Pubmed, Scopus, Emcare, Proquest and the Cochrane Central register of Controlled Trials. Inclusion criteria were all existing English, human, randomised controlled trials of interventions involving 4% articaine and 2% lidocaine in routine dental treatment. Twelve studies were included for meta-analysis using Cochrane Review Manager 5 software. Anaesthetic success odds ratios were calculated using a random-effects model.ResultsArticaine had a higher likelihood of achieving anaesthetic success than lidocaine overall and in all subgroup analyses with varying degrees of significance. Overall (OR: 2.17, 95% CI: 1.50, 3.15,I2 = 62%) articaine had 2.17 times the likelihood of anaesthetic success of lidocaine (P < 0.0001). For mandibular blocks (OR: 1.50, 95% CI: 1.14, 1.98,I2 = 0%) articaine had 1.5 times the likelihood of anaesthetic success of lidocaine (P = 0.004). For all infiltrations, maxillary and mandibular (OR: 2.78, 95% CI: 1.61, 4.79,I2 = 66%) articaine had 2.78 times the likelihood of anaesthetic success of lidocaine (P = 0.0002). None of the studies reported any major local anaesthetic-related adverse effects as a result of the interventions.ConclusionsArticaine is a safe and efficacious local anaesthetic for all routine dental procedures in patients of all ages, and more likely to achieve successful anaesthesia than lidocaine in routine dental treatment. Neither anaesthetic has a higher association with anaesthetic-related adverse effects.
Patterns of therapy initiation during the first decade for patients with follicular lymphoma who were observed at diagnosis in the rituximab era
Authors: Arushi Khurana  , Mwangi Raphael , Ansell Stephen M. , Habermann Thomas M. , Cerhan James R. , Strouse Christopher , Link Brian K. , Wang Yucai , King Rebecca L. , Macon William R. , Villasboas J. C. , Witzig Thomas E. , Maurer Matthew J. , Nowakowski Grzegorz S. 
Published: July 2021

AbstractImmediate treatment for asymptomatic, low-tumor burden follicular lymphoma (FL) has not shown an overall survival benefit over “watch and wait” (W/W) strategy. We estimated incidence of treatment initiation at specific time points and assessed its association with the presence of any criteria such as GELF, BNLI, GITMO at diagnosis. FL patients managed by W/W strategy were identified from the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic Lymphoma SPORE between 2002 and 2015. Cumulative incidence estimates of treatment initiation were calculated using transformation (as the first event) and death as competing risks. 401 FL patients were identified on W/W strategy. At a median follow-up of 8 years, 256 (64%) initiated treatment. For patients on the W/W strategy for 5 years, the likelihood of treatment initiation in the next 5 years was 12% compared to 43% at diagnosis unlike transformation rates which remained steady. Patients with any of popular treatment criteria at diagnosis did not have increased therapy initiation rates (44% vs. 42%) during the first 5 years or lymphoma-related death rates at 10 years (6% vs. 7%). Identifying biological differences in patients with early vs. late or no progression is a critical next step in understanding outcomes in W/W patients.
Metabolic syndrome and cardiovascular disease after haematopoietic cell transplantation (HCT) in adults: an EBMT cross-sectional non-interventional study
Authors: Greenfield D. M. , Salooja N. , Peczynski C. , van der Werf S. , Schoemans H. , Hill K. , Cortelezzi A. , Lupo-Stangellini M. , Özkurt Z. N. , Arat M. , Metzner B. , Turlure P. , Rovo A. , Socié G. , Mohty M. , Nagler A. , Kröger N. , Dreger P. , Labopin M. , Han T. S. , Tichelli A. , Duarte R. , Basak G. , Snowden J. A. 
Published: July 2021

AbstractMetabolic syndrome (MetS) is associated with cardiovascular disease in the general population and is also a potential cardiovascular risk factor in survivors of haematopoietic cell transplantation (HCT). We report an EBMT cross-sectional, multi-centre, non-interventional study of 453 adult HCT patients surviving a minimum of 2 years post-transplant attending routine follow-up HCT and/or late effects clinics in 9 centres. The overall prevalence of MetS was 37.5% rising to 53% in patients >50 years of age at follow-up. There were no differences in rates of MetS between autologous and allogeneic HCT survivors, nor any association with graft-versus-host disease (GvHD) or current immunosuppressant therapy. Notably, there was a significantly higher occurrence of cardiovascular events (CVE, defined as cerebrovascular accident, coronary heart disease or peripheral vascular disease) in those with MetS than in those without MetS (26.7% versus 9%, p < 0.001, OR 3.69, 95% CI 2.09–6.54, p < 0.001), and, as expected, MetS and CVE were age-related. Unexpectedly, CVE were associated with occurrence of second malignancy. Screening for and management of MetS should be integrated within routine HCT long-term follow-up care for both allogeneic and autologous HCT survivors. Further research is warranted, including randomised controlled trials of interventional strategies and mechanistic studies of cardiovascular risk in HCT survivors.
DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65
Authors: Lin Zixuan , Chen Chen , Yang Dongqin , Ding Jianqing , Wang Guanghui , Ren Haigang 
Published: July 2021

AbstractParkinson’s disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). DJ-1 acts essential roles in neuronal protection and anti-neuroinflammatory response, and its loss of function is tightly associated with a familial recessive form of PD. However, the molecular mechanism of DJ-1 involved in neuroinflammation is largely unclear. Here, we found that wild-type DJ-1, rather than the pathogenic L166P mutant DJ-1, directly binds to the subunit p65 of nuclear factor-κB (NF-κB) in the cytoplasm, and loss of DJ-1 promotes p65 nuclear translocation by facilitating the dissociation between p65 and NF-κB inhibitor α (IκBα).DJ-1knockout (DJ-1−/−) mice exhibit more microglial activation compared with wild-type littermate controls, especially in response to lipopolysaccharide (LPS) treatment. In cellular models, knockdown of DJ-1 significantly upregulates the gene expression and increases the release of LPS-treated inflammatory cytokines in primary microglia and BV2 cells. Furthermore,DJ-1deficiency in microglia significantly enhances the neuronal toxicity in response to LPS stimulus. In addition, pharmacological blockage of NF-κB nuclear translocation by SN-50 prevents microglial activation and alleviates the damage of DA neurons induced by microglialDJ-1deficiency in vivo and in vitro. Thus, our data illustrate a novel mechanism by which DJ-1 facilitates the interaction between IκBα and p65 by binding to p65 in microglia, and thus repressing microglial activation and exhibiting the protection of DA neurons from neuroinflammation-mediated injury in PD.
Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia
Authors: Kopach Olga , Esteras Noemí , Wray Selina , Abramov Andrey Y. , Rusakov Dmitri A. 
Published: July 2021

AbstractHuman iPSC lines represent a powerful translational model of tauopathies. We have recently described a pathophysiological phenotype of neuronal excitability of human cells derived from the patients with familial frontotemporal dementia and parkinsonism (FTDP-17) caused by theMAPT10+16 splice-site mutation. This mutation leads to the increased splicing of 4R tau isoforms. However, the role of different isoforms of tau protein in initiating neuronal dementia-related dysfunction, and the causality between theMAPT10+16 mutation and altered neuronal activity have remained unclear. Here, we employed genetically engineered cells, in which the IVS10+16 mutation was introduced into healthy donor iPSCs to increase the expression of 4R tau isoform in exon 10, aiming to explore key physiological traits of iPSC-derivedMAPTIVS10+16 neurons using patch-clamp electrophysiology and multiphoton fluorescent imaging techniques. We found that during late in vitro neurogenesis (from ~180 to 230 days) iPSC-derived cortical neurons of the control group (parental wild-type tau) exhibited membrane properties compatible with “mature” neurons. In contrast,MAPTIVS10+16 neurons displayed impaired excitability, as reflected by a depolarized resting membrane potential, an increased input resistance, and reduced voltage-gated Na+- and K+-channel-mediated currents. The mutation changed the channel properties of fast-inactivating Navand decreased the Nav1.6 protein level.MAPTIVS10+16 neurons exhibited reduced firing accompanied by a changed action potential waveform and severely disturbed intracellular Ca2+dynamics, both in the soma and dendrites, upon neuronal depolarization. These results unveil a causal link between theMAPT10+16 mutation, hence overproduction of 4R tau, and a dysfunction of human cells, identifying a biophysical basis of changed neuronal activity in 4R tau-triggered dementia. Our study lends further support to using iPSC lines as a suitable platform for modelling tau-induced human neuropathology in vitro.
Transgenic and genome-edited fruits: background, constraints, benefits, and commercial opportunities
Authors: Lobato-Gómez Maria , Hewitt Seanna , Capell Teresa , Christou Paul , Dhingra Amit , Girón-Calva Patricia Sarai 
Published: July 2021

AbstractBreeding has been used successfully for many years in the fruit industry, giving rise to most of today’s commercial fruit cultivars. More recently, new molecular breeding techniques have addressed some of the constraints of conventional breeding. However, the development and commercial introduction of such novel fruits has been slow and limited with only five genetically engineered fruits currently produced as commercial varieties—virus-resistant papaya and squash were commercialized 25 years ago, whereas insect-resistant eggplant, non-browning apple, and pink-fleshed pineapple have been approved for commercialization within the last 6 years and production continues to increase every year. Advances in molecular genetics, particularly the new wave of genome editing technologies, provide opportunities to develop new fruit cultivars more rapidly. Our review, emphasizes the socioeconomic impact of current commercial fruit cultivars developed by genetic engineering and the potential impact of genome editing on the development of improved cultivars at an accelerated rate.
A new relaying scheme for protection of transmission lines connected to DFIG‐based wind farms
Authors: Zare Javad , Pirooz Azad Sahar 
Published: July 2021

AbstractThis paper presents a new protection scheme with low communication capacity requirement for protecting lines connected to a doubly‐fed induction generator (DFIG)‐based wind farm (WF). The proposed relaying scheme addresses the line protection challenges which stem from the non‐synchronous frequency component of the current fed from a DFIG‐based WF during a short‐circuit fault. The fault current frequency of a DFIG‐based WF deviates from the synchronous frequency during a fault, which affects the operation of distance relays. In such a scenario, the distance relay located at the WF terminal may lose its coordination with downstream relays, resulting in unnecessary tripping. The proposed scheme relies on the impedance trajectory captured by the local relay, local fault current characteristics, and the frequency tracking of the fault current measured at the distance relays located at the two ends of the transmission line connected to a DFIG‐based WF. The reliable performance of the proposed scheme is verified on a 4‐bus test system under balanced and unbalanced faults during super‐ and sub‐synchronous operating modes of the DFIG as well as its robustness against power system disturbances.