bluuebunny/crossref_metadata_2025_split huggingface dataset:
Material exploration via designing spatial arrangement of octahedral units: a case study of lead halide perovskites
Authors: Fu Pengfei , Hu Sanlue , Tang Jiang , Xiao Zewen 
Published: April 2021

AbstractHalide perovskites have attracted tremendous attention as semiconducting materials for various optoelectronic applications. The functional metal-halide octahedral units and their spatial arrangements play a key role in the optoelectronic properties of these materials. At present, most of the efforts for material exploration focus on substituting the constituent elements of functional octahedral units, whereas designing the spatial arrangement of the functional units has received relatively little consideration. In this work, via a global structure search based on density functional theory (DFT), we discovered a metastable three-dimensional honeycomb-like perovskite structure with the functional octahedral units arranged through mixed edge- and corner-sharing. We experimentally confirmed that the honeycomb-like perovskite structure can be stabilized by divalent molecular cations with suitable size and shape, such as 2,2′-bisimidazole (BIM). DFT calculations and experimental characterizations revealed that the honeycomb-like perovskite with the formula of BIMPb2I6, synthesized through a solution process, exhibits high electronic dimensionality, a direct allowed bandgap of 2.1 eV, small effective masses for both electrons and holes, and high optical absorption coefficients, which indicates a significant potential for optoelectronic applications. The employed combination of DFT and experimental study provides an exemplary approach to explore prospective optoelectronic semiconductors via spatially arranging functional units.
The past and present of pandemic management: health diplomacy, international epidemiological surveillance, and COVID-19
Authors: D’Abramo Flavio 
Published: April 2021

AbstractThe establishment of international sanitary institutions, which took place in the context of rivalry among the great European powers and their colonial expansion in Asia, allowed for the development of administrative systems of international epidemiological surveillance as a response to the cholera epidemics at the end of the nineteenth century. In this note, I reflect on how a historical analysis of the inception of international epidemiological surveillance and pandemic management helps us to understand what is happening in the COVID-19 pandemic today.
Tetracycline antibiotics
Authors: Ramachanderan Raghavendra , Schaefer Bernd 
Published: April 2021

AbstractTetracyclines belong to the first broad-spectrum, well-tolerated, and easy-to-administer antibiotics, which are effective against plague, cholera, typhoid, syphilis, Legionnaire’s disease, and anthrax. Some can also be used to treat malaria, Lyme disease, tuberculosis, Rocky Mountain spotted fever, and leprosy. Humans first encountered these chemical species involuntarily in ancient times, as evidenced from the analysis of bone samples dating back more than 1500 years. Shortly after World War II, they were “rediscovered” at Lederle Laboratories and Pfizer as a result of an intense search for new antibiotics. Their bacteriostatic action is based on the inhibition of protein biosynthesis. Since the structure elucidation by Robert Woodward, Lloyd Hillyard Conover, and others in the 1950s, tetracyclines have become preferred targets for natural product synthesis. However, on industrial scale, they became readily available by fermentation and partial synthesis. Their casual and thoughtless use in the initial decades after launch not only in humans but for veterinary purposes and as growth-enhancement agents in meat production rapidly led to the emergence of resistance. In an arms race for new antibiotics, more and more new drugs have been developed to deal with the threat. In this ongoing endeavor, a remarkable milestone was set by Andrew Myers in 2005 with the convergent total synthesis of (−)-doxycycline, as well as numerous azatetracyclines and pentacyclines, which has inspired chemists in the pharmaceutical industry to discover novel and highly active tetracyclines in recent years.Graphic abstract
Functional and Patient Reported Outcomes Following Total Glans Resurfacing
Authors: Preto Mirko , Falcone Marco , Blecher Gideon , Capece Marco , Cocci Andrea , Timpano Massimiliano , Gontero Paolo 
Published: April 2021

ABSTRACTBackgroundWhilst there is a trend away from aggressive nonorgan sparing surgical treatments for malignant penile disease, a variety of penile preservation options exist but functional outcomes and patient reported outcomes (PROs) in this area are poorly reported to date.AimThe aim of this study is to report functional outcomes and PROs of total glans resurfacing (TGR) in a consecutive series of patients with lichen sclerosis (LS) or localized penile cancer (PC).MethodsFrom 2004 to 2018 a consecutive series of patients underwent TGR for the management of LS or localized PC in a tertiary referral network. Patient clinical records and operative notes were retrospectively reviewed. Statistical analysis was conducted with Stata 12.OutcomesUrinary and sexual outcomes were recorded utilizing both the International Index of Erectile Function (IIEF) and International Prostate Symptom Score (IPSS) validated questionnaires while PROs were extrapolated from a 5-item “ad hoc” telephone questionnaire administered at 1 year post procedure.RESULTS37 consecutive patients were enrolled. Histology results demonstrated LS in 16 patients, with the remaining 21 having a diagnosis of PC. The most common reasons for patient presentation were local pain (32.4%), pruritus (37.8%) and bleeding (29.7%). Median follow-up was 22 (IQR 13–77) months. Median age was 62 (IQR 55–68).Neither of the questionnaires assessing urinary and sexual function showed any significant deterioration after surgery. Glans sensitivity was fully maintained in 89.2% of cases. 94.5% of patients reported to be fully satisfied with the aesthetic appearance of the penis and would consider undergoing the same procedure again if necessary. 91.9% of patients would recommend the same procedure to someone else. An overall improvement of the quality of life was reported by 86.4% of patients.Clinical ImplicationsTGR should be considered a treatment of choice for selected cases of benign or malignant penile lesionsStrengths and LimitationsOur study has some limitations, the first being its retrospective nature. Furthermore, despite being one of the largest series to date, follow-up duration is somewhat limited and a control group is lacking.CONCLUSIONTGR represents an excellent surgical option ensuring satisfactory voiding and sexual function, as well as cosmesis for selected cases of penile lesions.
Cross-Sectional Survey to Assess Health-Care Workers’ Grief Counseling for Bereaved Families of COVID-19 Victims in Wuhan, China
Authors: Gao Xudong , Wang Zhimin , Kong Chan , Fan Hongru , Zhang Juan , Wang Jing , Tan Lingling , Wang Jinyao 
Published: April 2021

AbstractObjective:This research aimed to examine health-care workers’ grief counseling for bereaved families of coronavirus disease 2019 (COVID-19) victims in China. Our research may provide a new opportunity to stimulate development of grief counseling in China.Methods:A cross-sectional survey was conducted with 724 health-care workers selected by convenience sampling from 7 hospitals in Wuhan. Data collection tools included a sociodemographic questionnaire, the skills of grief counseling scale (SGCS), and the attitudes of grief counseling scale (AGCS).Results:The average SGCS score was 18.96 ± 4.66, whose influencing factors consisted of sense of responsibility, frequency of contact with bereaved families, and relevant training (P < 0.05). The average AGCS score was 33.36 ± 8.70, whose influencing factors consisted of other grief counseling skills, communication skills, education background, and relevant training (P < 0.05).Conclusions:The skills and attitudes toward grief counseling among health-care workers combating COVID-19 were at a lower level in Wuhan, China, indicating the need to build a comprehensive grief counseling system, establish a standardized training course, and strengthen the popularization of grief counseling services to the public.
National Indifference in Post-Ottoman Spaces: A Case from Northwest Bulgaria
Authors: Jakoubek Marek 
Published: April 2021

AbstractThis study represents an application of the concept of national indifference in the Post-Ottoman Balkans. It addresses the question of why two minority communities in Northwest Bulgaria in the first half of 20th century – the Protestant Voyvodovo community and the Catholic community of Bărdarski Geran, both marked by a strong principle of religious endogamy, intermarried. The author maintains that the main reason why these two communities intermarried was – despite all the differences between them – their national indifference, a parameter that both communities shared. These marriages did not cross the ethno-national boundary (the communities were nationally indifferent and thus ethno-national borders did not divide them). Contrary to standard understandings of the concept of national indifference, the author emphasizes that national indifference can be said to have two sides. On the one hand, nationally indifferent groups represent those in which the “we-they” opposition does not follow national lines, while on the other hand these groups identify and organize themselves on the basis of principles other than national ones. In the example of the inhabitants of Voyvodovo and Bărdarski Geran, this principle was religion. The appreciation of the “positive” side of national indifference enables us to grasp “the native’s point of view,” how people themselves perceived and understood their reality, their identities, and loyalties.
PLINY, TACITUS AND THE MONUMENTS OF PALLAS
Authors: McNamara James 
Published: April 2021

AbstractThis article is a discussion of Plin.Ep. 7.29 andEp. 8.6, in which he presents his reaction to seeing the grave monument of Marcus Antonius Pallas, the freedman and minister of the Emperor Claudius, beside the Via Tiburtina. The monument records a senatorial vote of thanks to Pallas, and Pliny expresses intense indignation at the Senate's subservience and at the power and influence wielded by a freedman. This article compares Pliny's letters with Tacitus’ account of the senatorial vote of thanks to Pallas atAnn. 12.52–3 and explores the differences between the ways in which the two authors encourage readers to relate to past events. It is noted that the Pallas letters are unusual amongst Pliny's letters for their treatment of material unconnected with the life and career of Pliny and his friends, and argued that inEp. 7.29 Pliny uses language and attitudes drawn from satire to evoke the past.Ep. 8.6 is read as an idiosyncratic piece of historical enquiry, considering Pliny's use of citation and his anonymization of historical individuals. Both letters are considered in the context of the surrounding letters, and a hypothesis is offered regarding the identity of their addressee Montanus, considering evidence from Tacitus’HistoriesandAnnals. Discussion of Tac.Ann.12.52–3 focusses on the use of irony. Pliny's evocation ofenargeia(‘vividness’) is compared with that of Tacitus. The article concludes with comparison of the historical accounts offered by Pliny and Tacitus through reflection on Juvenal,Satire1.
A note on extensions of multilinear maps defined on multilinear varieties
Authors: Gowers W. T. , Milićević L. 
Published: April 2021

AbstractLet $G_1, \ldots , G_k$ be finite-dimensional vector spaces over a prime field $\mathbb {F}_p$. A multilinear variety of codimension at most $d$ is a subset of $G_1 \times \cdots \times G_k$ defined as the zero set of $d$ forms, each of which is multilinear on some subset of the coordinates. A map $\phi$ defined on a multilinear variety $B$ is multilinear if for each coordinate $c$ and all choices of $x_i \in G_i$, $i\not =c$, the restriction map $y \mapsto \phi (x_1, \ldots , x_{c-1}, y, x_{c+1}, \ldots , x_k)$ is linear where defined. In this note, we show that a multilinear map defined on a multilinear variety of codimension at most $d$ coincides on a multilinear variety of codimension $O_{k}(d^{O_{k}(1)})$ with a multilinear map defined on the whole of $G_1\times \cdots \times G_k$. Additionally, in the case of general finite fields, we deduce similar (but slightly weaker) results.
On non-separated zero sequences of solutions of a linear differential equation
Authors: Chyzhykov Igor , Long Jianren 
Published: April 2021

AbstractLet $(z_k)$ be a sequence of distinct points in the unit disc $\mathbb {D}$ without limit points there. We are looking for a function $a(z)$ analytic in $\mathbb {D}$ and such that possesses a solution having zeros precisely at the points $z_k$, and the resulting function $a(z)$ has ‘minimal’ growth. We focus on the case of non-separated sequences $(z_k)$ in terms of the pseudohyperbolic distance when the coefficient $a(z)$ is of zero order, but $\sup _{z\in {\mathbb D}}(1-|z|)^p|a(z)| = + \infty$ for any $p > 0$. We established a new estimate for the maximum modulus of $a(z)$ in terms of the functions $n_z(t)=\sum \nolimits _{|z_k-z|\le t} 1$ and $N_z(r) = \int_0^r {{(n_z(t)-1)}^ + } /t{\rm d}t.$ The estimate is sharp in some sense. The main result relies on a new interpolation theorem.
France's Informal Empire in the Mediterranean, 1815–1830
Authors: Dzanic Dzavid 
Published: April 2021

AbstractRecent works on France's informal projection of power have begun remapping French imperialism during the nineteenth century. More studies in this vein could broaden our understanding of informal empire as an analytical category by decentring it from its roots in British imperial studies. This article argues that between 1815 and 1830, French diplomats remoulded the Regency of Tunisia into an informal imperial periphery. Although they lacked the military and economic leverage of their British counterparts, French consuls coerced the Tunisian rulers into submission by wielding threats and treaties. This strategy unfolded in three stages. First, the consuls used rumours of a possible invasion in order to impose a new vision of international law and dismantle the corsair system in the Regency. Second, they claimed French territorial sovereignty over a part of the Tunisian coast by appealing to the international legal norms enshrined in the existing treaties. And, third, the Tunisian ruler accepted most consular demands following the French invasion of Algeria in 1830. Tunisia's entrance into the French imperial orbit in turn led French diplomats to seek the establishment of French economic ascendency in Tunisia during the early 1830s.
Inadvertent reproduction of Eurocentrism in IR: The politics of critiquing Eurocentrism
Authors: Tolay Juliette 
Published: April 2021

AbstractThe study of Eurocentrism has become a hallmark of postcolonial International Relations theories. Of particular concern in this literature has been the resilience of Eurocentrism despite conscious efforts to move towards a post-Eurocentric understanding of world politics. This study argues that while existing works have highlighted many of the reasons why Eurocentrism persists today, it has not been sufficiently identified and conceptualised. In particular, why some policy actors, who have a vested interest in moving beyond Eurocentrism, inadvertently reproduce Eurocentrism? This article proposes to distinguish between different types of inadvertent reproductions. In particular it highlights rhetorical critique, deconstruction, decentring and dehierarchising, as different ways to critique, inadvertently reproduce and partially modify Eurocentrism. To illustrate this situation, this article looks at Turkey's migration policies and documents how Turkish governing elites have openly claimed the need to upend the Eurocentric order, yet have reproduced it in practice.
Sarcopenia and homocysteine: is there a possible association in the elderly? A narrative review
Authors: De Giuseppe Rachele , Tomasinelli Chiara Elena , Vincenti Alessandra , Di Napoli Ilaria , Negro Massimo , Cena Hellas 
Published: April 2021

AbstractBackground:Sarcopenia (SA) is a progressive skeletal muscle disorder, associated with increased risk of adverse outcomes, including falls, fractures, physical disability and mortality. Several risks factors may contribute to the development of SA in the elderly; among them, nutrition plays a key role in muscle health. The elderly are at risk of inadequate intake in terms of micronutrients affecting muscle homeostasis, such as B vitamins, related to homocysteine (Hcy) metabolism.Objectives and methods:This narrative review analysed the association between increased Hcy levels and SA, according to the criteria of the International Working Group on Sarcopenia, the European Working Group on Sarcopenia in Older People and the Asian Working Group for Sarcopenia. The authors focused not only on SA per se but also on exploring the association between increased Hcy levels and components of SA, including muscle mass, muscle strength and physical performance.Results:Results are inconsistent, except for muscle mass, showing no significant associations with Hcy levels.Conclusions:Few and conflicting data emerged in this review on the association between SA and increased Hcy levels due to numerous differences between studies that change the significance of the association of Hcy and SA, as well as the muscle strength, muscle mass and physical performance. Furthermore, because the ageing process is not uniform in the population owing to differences in genetics, lifestyle and general health, chronological age fails to address the observed heterogeneity among the ‘elderly’ of the studies reported in this revision. Therefore, further studies are still needed.
What are language learners looking for in a collocation consultation system? Identifying collocation look-up patterns with user query data
Authors: Wu Shaoqun , Fitzgerald Alannah , Yu Alex , Chen Zexuan 
Published: April 2021

AbstractCorpus consultation with concordancers has been recognized as a promising way for learners to study and explore language features such as collocations at their own pace and in their own time. This study examined 1.5 million search queries sent to a collocation consultation tool called FlaxCLS (Flexible Language Acquisition Collocation Learning System; http://flax.nzdl.org) over a period of two years to identify learners’ collocation look-up patterns. This paper examines and characterizes learners’ look-up patterns as they entered search queries, clicked on the query formation aids provided by the system, and navigated through the different levels of collocation information returned by the system to support collocation learning. We looked at how learners formulated query terms, and we analyzed the characteristics of query words learners entered, the characteristics of collocations they preferred, and the sample sentences they checked. Our collocation look-up pattern analyses, similar to traditional user query analyses of the web, provide interesting and revealing insights that are hard to obtain from small-scale user studies. The findings provide valuable information and pedagogical implications for data-driven learning (DDL) researchers and language teachers in designing tailored collocation consultation systems and activities. This paper also presents multidimensional analyses of learner query data, which, to the best of our knowledge, have not been explored in DDL research.
EMA and FDA psychiatric drug trial guidelines: assessment of guideline development and trial design recommendations
Authors: Boesen Kim , Gøtzsche Peter C. , Ioannidis John P. A. 
Published: April 2021

Abstract

Aims
The European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) produce guidelines for the design of pivotal psychiatric drug trials used in new drug applications. It is unknown who are involved in the guideline development and what specific trial design recommendations they give.

Methods
Cross-sectional study of EMA Clinical Efficacy and Safety Guidelines and FDA Guidance Documents. Study outcomes: (1) guideline committee members and declared conflicts of interest; (2) guideline development and organisation of commenting phases; (3) categorisation of stakeholders who comment on draft and final guidelines according to conflicts of interest (‘industry’, ‘not-industry but with industry-related conflicts’, ‘independent’, ‘unclear’); and (4) trial design recommendations (trial duration, psychiatric comorbidity, ‘enriched design’, efficacy outcomes, comparator choice). Protocol registration https://doi.org/10.1101/2020.01.22.20018499 (27 January 2020).

Results
We included 13 EMA and five FDA guidelines covering 15 psychiatric indications. Eleven months after submission, the EMA had not processed our request regarding committee member disclosures. FDA offices draft the Guidance Documents, but the Agency is not in possession of employee conflicts of interest declarations because FDA employees generally may not hold financial interests (although some employees may hold interests up to $15,000). The EMA and FDA guideline development phases are similar; drafts and final versions are publicly announced and everybody can submit comments. Seventy stakeholders commented on ten guidelines: 38 (54%) ‘industry’, 18 (26%) ‘not-industry but with industry-related conflicts’, six (9%) ‘independent’ and eight (11%) ‘unclear’. They submitted 1014 comments: 640 (68%) ‘industry’, 243 (26%) ‘not-industry but with industry-related conflicts’, 44 (5%) ‘independent’ and 20 (2%) ‘unclear’ (67 could not be assigned to a specific stakeholder). The recommended designs were generally for trials of short duration; with restricted trial populations; allowing previous exposure to the drug; and often recommending rating scale efficacy outcomes. EMA mainly recommended three arm designs (both placebo and active comparators), whereas FDA mainly recommended placebo-controlled designs. There were also other important differences and FDA's recommendations regarding the exclusion of psychiatric comorbidity seemed less restrictive.

Conclusions
The EMA and FDA clinical research guidelines for psychiatric pivotal trials recommend designs that tend to have limited generalisability. Independent and non-conflicted stakeholders are underrepresented in the guideline development. It seems warranted with more active involvement of scientists and independent organisations without conflicts of interest in the guideline development process.