bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Kreativitas Melalui Eksplorasi
Authors: Heldanita Heldanita 
Published: August 2021

Sejatinya setiap orang mempunyai kreativitas yang berbeda-beda, baik anak-anak maupun orang dewasa. Hampir semua pekerjaan menuntut kreativitas, terutama menjadi seorang guru, karena semakin kreatif seorang guru, maka semakin menyenangkan juga pembelajaran yang berlangsung. Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan kreativitas melalui eksplorasi, terfokus pada kreativitas anak usia dini. Penelitian ini merupakan kajian literatur dengan mengkaji beberapa literatur yang berkaitan dengan kreativitas dalam eksplorasi dengan metode dokumentasi. Hasil penelitian menunjukkan bahwa : 1) Lingkungan keluarga, orangtua, lingkungan dan guru menjadi salah satu faktor penting dalam mengembangkan kreativitas anak, 2) perkembangan kreativitas anak juga dapat dikembangan dengan memanfaatkan lingkungan sekitar sebagai tempat tinggal anak dan kegiatan-kegiatan yang memanfaatkan lingkungan sekitar sebagai medianya misalnya, belajar pada alam dan outbond learning, 3) perkembangan kreativitas anak sejatinya tumbuh sejak anak berada pada masa bayi, sehingga sedini mungkin anak perlu diberikan stimulus agar orangtua dapat memahami kecakapan, kecerdasan dan kebutuhan anak, agar anak dapat berkembang dengan baik, 4) perkembangan kreativitas anak berbeda-beda dari setiap tahap perkembangan anak dan juga berbeda-beda cara menstimulasinya.
Unendlichkeit im Angesicht des Todes
Authors: Gerhardt Volker 
Published: August 2021

Zusammenfassung
Der vorliegende Text ist in gleichermaßen philosophischer wie theologischer Perspektive bemüht, die These von der definitiven Endlichkeit des Menschen (einschließlich seiner unwiderruflichen Sterblichkeit) zu belegen. Dies geschieht in der Doppelung von Veranschaulichung und begrifflicher Argumentation. Unter Berufung auf die Sozialität und Abstraktion erfordernden Leistungen des menschlichen Bewusstseins einerseits und der alles Individuelle nach Art einer Institution überformenden Präsenz des menschlichen Geistes andererseits wird kenntlich gemacht, warum der Mensch in einer seine Existenz umfassenden Sphäre denkt und fühlt, in der er über seine zeitlich und leiblich beschränkte Individualität notwendig hinausgeht.
Low-dose short synacthen test with salivary cortisol in patients with suspected central adrenal insufficiency
Authors: Ceccato Filippo , Selmin Elisa , Antonelli Giorgia , Barbot Mattia , Daniele Andrea , Boscaro Marco , Plebani Mario , Scaroni Carla 
Published: August 2021

Context
The low-dose short synacthen test (LDSST) is recommended for patients with suspected central adrenal insufficiency (AI) if their basal serum cortisol (F) levels are not indicative of an intact hypothalamic–pituitary–adrenal (HPA) axis.

Objective
To evaluate diagnostic threshold for salivary F before and 30 min after administering 1 μg of synacthen, performed before 09:30 h.

Design
A cross-sectional study from 2014 to 2020.

Setting
A tertiary referral university hospital.

Patients
In this study, 174 patients with suspected AI, 37 with central AI and 137 adrenal sufficient (AS), were included.

Main outcome measure
The diagnostic accuracy (sensitivity (SE), specificity (SP)) of serum and salivary F levels measured, respectively, by chemiluminescence immunoassay and liquid chromatography-tandem mass spectrometry.

Results
Low basal serum or salivary F levels could predict AI. For the LDSST, the best ROC-calculated threshold for serum F to differentiate AI from AS was 427 nmol/L (SE 79%, SP 89%), serum F > 500 nmol/L reached SP 100%. A salivary F peak > 12.1 nmol/L after administering synacthen reached SE 95% and SP 84% for diagnosing central AI, indicating a conclusive reduction in the likelihood of AI. This ROC-calculated threshold for salivary F was similar to the 2.5th percentile of patients with a normal HPA axis, so it was considered sufficient to exclude AI. Considering AS those patients with salivary F > 12.1 nmol/L after LDSST, we could avoid unnecessary glucocorticoid treatment: 99/150 subjects (66%) had an inadequate serum F peak after synacthen, but salivary F was >12.1 nmol/L in 79 cases, who could, therefore, be considered AS.

Conclusions
Salivary F levels > 12.1 nmol/L after synacthen administration can indicate an intact HPA axis in patients with an incomplete serum F response, avoiding the need to start glucocorticoid replacement treatment.
The effect of LH rise during artificial frozen–thawed embryo transfer (FET) cycles
Authors: Khoury Samer , Kadour-Peero Einav , Calderon Ilan 
Published: August 2021

Purpose
To evaluate the association between a rise in serum luteinizing hormone (LH) levels during artificial frozen–thawed embryo transfer (FET) cycles and clinical pregnancy rate.

Methods
A retrospective cohort study of women undergoing artificial FET cycles. We compared cycles in which LH double itself from the early follicular phase and further (group A) to cycles without a rise in LH (group B). Endometrium preparation was achieved by administration of 2 mg three times per day estradiol valerate tablets. Embryo transfer (ET) was conducted after achieving endometrial thickness > 7 mm and vaginal progesterone was added according to the embryo’s age. A beta-hCG was measured 13–14 days after ET. Clinical pregnancy was diagnosed on transvaginal ultrasound.

Results
Data from 984-FET cycles were retrieved. LH, exogenous estradiol (E2), progesterone values, endometrial thickness, and pregnancy outcomes were available in all patients. From 984-FET cycles, 629 (63.9%) had a doubling, and 355 (36.07%) had no rise in LH. Patients mean age was 30 years, similar in both groups. A multivariable logistic regression analysis was calculated to assess the effect of LH rise and pregnancy outcomes, after adjusting for confounders including a rise in E2 level and endometrial thickness. In this model, there was no association between doubling LH values and pregnancy rates (adjusted odds ratio: 1.06, 95% CI: 0.75–1.5, P = 0.74).

Conclusion
LH rise during artificial FET cycles does not alter pregnancy rates. Apparently, hormonal monitoring of LH levels may not yield useful information in the artificial FET cycle and may be omitted.

Lay summary
Supplementation of estradiol, a hormone produced by the ovaries, starting at the beginning of the menstrual cycle of an artificially frozen embryo transfer (FET) can lead to a rise in luteinizing hormone (LH), the hormone that induces ovulation. Such a rise in LH may interfere with embryo implantation, the process where the embryo attaches to the inner lining of the uterus and, therefore, could affect the chances of pregnancy. The current study is the first to assess the effect of a dynamic rise in LH levels during FET cycles on pregnancy rates. This study found no difference in pregnancy rates between FET cycles where the LH doubled compared to cycles without such a rise in LH. Larger, prospective studies should be conducted to assess the impact of LH elevation on pregnancy outcomes.
Analysis of neurotransmitter catecholamines and related amines in human urine and serum by chromatography and capillary electrophoresis with 1, 3, 5, 7-tetramethyl-8-(N-hydroxysuccinimidyl propionic ester)-difluoro-boradiaza-s-indacene
Authors: Cao Liwei , Wu Lizhen , Zhong Hailan , Wu Hao , Zhang Siyun , Meng Jianxin , Li Fengyu 
Published: August 2021

Abstract
Two sensitive and effective methods were developed for the detection of catecholamines and related biogenic amines (dopamine, epinephrine, norepinephrine, serotonin, levodopa and tyramine) using high performance liquid chromatography with fluorescence detection and capillary electrophoresis with laser-induced fluorescence detection. A BODIPY fluorescent dye, 1, 3, 5, 7-tetramethyl-8-(N-hydroxysuccinimidyl propionic ester)-difluoroboradiaza- s-indacene was used as pre-column derivatization reagent. The separation and derivatization conditions were optimized in detail. In high performance liquid chromatography with fluorescence detection method, the derivatization reaction was completed at 35 °C for 20 min. At the wavelength of λ
ex/λ
em = 493 nm/513 nm, dopamine, epinephrine, norepinephrine, and levodopa derivatives achieved baseline separation within 15 min. The limits of detection (S/N = 3) were 1.0, 2.0, 5.0, and 0.5 nmol/L, respectively. In capillary electrophoresis with laser-induced fluorescence detection method, the derivatization reaction was completed at 25 °C for 20 min. Serotonin, tyramine and dopamine derivatives reached baseline separation within 10 min at the wavelength of λ
ex = 473 nm. The limits of detection (S/N = 3) for serotonin, tyramine, and dopamine were 0.3, 0.02, and 0.2 nmol/L, respectively. The amino compounds in human serum and urine samples were detected successfully, and the recoveries were 93.3%–106.7% and 91.0%–103.1%, respectively.
Assessment of flatfoot index and prevalence of musculoskeletal disorders of the foot in young athletes: swimming, rowing and weightlifting
Authors: Miguel Andrés Israel , Pons Portugal Milagros , Mayagoitia Vázquez José De Jesús , Carrum Siller Elias Gabriel , Pérez Rodríguez Ma. Eugenia 
Published: August 2021

Objectives: The objective of this work was to analyze the morphology of the soles of the feet in young athletes to find the prevalence of these pathologies through the Chippaux-Smirak index.
Material and Methods: Seventy-five athletes between nine and twenty years old participated in the study (56% female and 44% male), the average mass was 62.92 ± 13.46kg and the average height was 1.67 ± 0.11m. The sports considered in the study were weightlifting, swimming, and rowing.
Results: The results clearly show that flatfeet in adolescents and young adults is a condition with a low prevalence level, 10.7% and 12% for the right and left foot, respectively. One of the most outstanding results found in the study is the high prevalence of cavus foot, where women are the most affected by this pathology. Furthermore, swimming presented the highest prevalence of cavus foot, 42.1% and 52.6% for the right and left foot, respectively.
Conclusion: In conclusion, the understanding of the morphology of the soles of the feet can help to determine the foot type in these three different sports, and therefore, it can be implemented physiotherapeutic treatments or orthotics devices for overcome the musculoskeletal disorders and prevent future injures.
Na potência do envolvimento: palavras de intelectuais indígenas
Authors: De Campos Maciel Josemar , Marques Pereira Levi , Leite Chaparro Yan 
Published: August 2021

O trabalho que segue apresenta variações de uma concepção do desenvolvimento inspirada no esforço de diálogo com o pensamento indígena. Nossa metodologia é hermenêutica, e desdobra-se em dois momentos. O primeiro é uma revisão sintética da relação entre a colonização, o desenvolvimento e a sobrevivência da vocalidade indígena. Para este momento, usamos a literatura científica do campo historiográfico e filosófico. O segundo momento é uma apresentação em categorias tipológicas de algumas visões indígenas do que viria a ser desenvolvimento, construídas a partir da leitura de textos produzidos por intelectuais indígenas. O resultado esperado do trabalho é contribuir com o adensamento do respeito pela contribuição dos indígenas para pensar uma versão saudável, sustentável, justa e nativa do desenvolvimento do Brasil, que denominamos como “envolvimento”, adotando a formulação expressa por um indígena kaiowá, autor de um dos textos no presente dossiê.
Filming movies of attosecond charge migration with high harmonic spectroscopy
Authors: He Lixin , Sun Siqi , Lan Pengfei , He Yanqing , Wang Bincheng , Wang Pu , Zhu Xiaosong , Li Liang , Cao Wei , Lu Peixiang , Lin Chii-Dong 
Published: August 2021

Abstract
Electron migration in molecules is the progenitor of chemical reactions and biological functions after light-matter interaction. Following this ultrafast dynamics, however, has been an enduring endeavor. Recently, it has been suggested that high-harmonic spectroscopy (HHS) is able to probe dynamics with attosecond temporal and sub-˚angstr¨om spatial resolution. Still, real-time visualization of single-molecule dynamics continues to be a great challenge because experimental harmonic spectra are due to the coherent averages of light emission from individual molecules of different alignments. Here we demonstrate that the uniting of machine learning (ML) algorithm and HHS in two-color laser pulses enables us to retrieve the complex amplitude and phase of harmonics from single fixed-in-space molecule. From the complex single-molecule dipoles for different harmonics, we construct a movie of electron migration after tunnel ionization of the molecules at time steps of 50 attoseconds. Moreover, the angular dependence of molecular charge migration is fully resolved. By examining the movie, we observe that electron holes do not just “migrate” along the laser direction, but may “swirl” around the atom centers. Our ML-based HHS establishes a general reconstruction scheme for studying ultrafast charge migration in molecules, paving a way for further advance in tracing and controlling photochemical reactions by femtosecond lasers.
Prognosis assessment of CD44+/CD24- in Breast Cancer Patients: a systematic review and meta-analysis
Authors: Gu Jingjing , Chen Dandan , li Zhiqiang , Yang Yongliang , Ma Zhaoming , Huang Guanhong 
Published: August 2021

Abstract
Purpose: This meta-analysis investigated the relationships between the CD44+/CD24- phenotype and tumor size, lymph node metastasis, distant metastasis, disease-free survival (DFS), and overall survival (OS) in 8036 postoperative breast cancer patients enrolled in 23 studies.Methods: A literature search of PubMed, Medline, Cochrane, Embase, and PMC was conducted to identify eligible studies. The combined odds ratios (ORs) and 95% confidence intervals (95%CIs) were analyzed to evaluate the relationships between the CD44+/CD24- phenotype and the pathological and biological characteristics of breast cancer patients, and the combined hazard ratios (HRs) and 95% CIs were calculated to evaluate the relationships between CD44+/CD24- and DFS and OS of breast cancer petients using Stata12.0 software.Results: The CD44+/CD24- phenotype were not related to the tumor size (tumor size > 2.0 cm vs ≤ 2.0 cm, combined OR = 0.98, 95%CI: 0.68–1.34, p = 0.792) and didn’t promote lymph node metastasis (lymph node metastasis vs. no lymph node metastasis, combined OR = 0.94, 95% CI: 0.71–1.26, p = 0.692) and distant metastasis (distant metastasis vs no distant metastasis, combined OR = 3.88, 95% CI: 0.93–16.24, p = 0.064). The CD44+/CD24- phenotype was negatively correlated with postoperative DFS (HR = 1.67, 95% CI: 1.35–2.07, p <0.00001) and OS (combined HR = 1.52, 95%CI: 1.21–1.91, p = 0.0004).Conclusion: These results suggested expression of the CD44+/CD24- phenotype can be used as a reliable indicator of clinical prognosis and a potential therapeutic targets in breastcancer patients.
Quantum Enhanced Filter: QFilter
Authors: Atchade Parfait , Alonso-Linaje Guillermo 
Published: August 2021

Abstract
Convolutional Neural Networks (CNN) are used mainly to treat problems with many images characteristic of Deep Learning. In this work, we propose a hybrid image classification model to take advantage of quantum and classical computing. The method will use the potential that convolutional networks have shown in artificial intelligence by replacing classical filters with variational quantum filters. Similarly, this work will compare with other classification methods and the system's execution on different servers. The algorithm's quantum feasibility is modelled and tested on Amazon Braket Notebook instances and experimented on the Pennylane's philosophy and framework.
The Prognostic Factor for Recurrence in Advanced-Stage High-Grade Serous Ovarian Cancer After Complete Clinical Remission: A Nested Case-Control Study
Authors: Wang Qiao , Zheng Ying , Wang Ping , Zhang Jiawen , Liu Hui , Li Qingli , Yin Rutie , Bian Ce , Peng Hongling , Peng Zhilan 
Published: August 2021

Abstract
Background
Women with advanced-stage high-grade serous ovarian cancer (HGSOC) are likely to have a bad prognosis. Relapses are common in patients even with no evidence of disease after primary treatment. We aimed to identify the prognostic factors for disease recurrence in these patients.
Methods
A nested case-control study was conducted in a large medical center in Southwest China. The primary outcome was recurrence of disease within 3 years after clinical remission (CR). Cox regression was used to calculate the time to event analysis in different groups.
Results
Ninety-seven patients were finally included. Fifty-seven patients (58.8%) relapsed within 3 years after CR. Among all the variables, the difference in posttreatment CA-125 level was statistically significant (P ༜0.05) between the recurrent group and the progression-free group in both univariate and multivariable analysis. A cutoff value was set at the median level in the recurrent group (10 U/ml) to categorize patients into two arms. In Cox regression, the posttreatment CA-125 level was identified as a prognostic factor for recurrence with an OR of 1.05 (95% CI: 1.02–1.10, P = 0.033). The median time (from initiation of treatment) until relapse was 25 months for patients whose posttreatment CA-125 levels were higher than 10 U/ml, while it was undefined for patients whose posttreatment CA-125 level were ≤ 10 U/ml. Patients with a higher posttreatment CA-125 level showed an increased risk for OC relapse compared to those with a lower posttreatment CA-125 level. Furthermore, as shown in line graphs recording serum CA-125 levels during follow-up in each recurrent case, the increments of serum CA-125 levels were delayed in recurrent OC patients who had a posttreatment CA125 level ≤ 10 U/ml compared with those with a higher CA-125 level.
Conclusion
A low serum CA-125 level after primary treatment was a potential prognostic factor in women with advanced HGSOC.
Multiple exposures to high concentration of selenate significantly improve selenate tolerability, red elemental selenium (Se0) and selenoprotein biosynthesis in Herbaspirillum camelliae WT00C
Authors: Ni Xuechen , Tian Jinbao , Chen Changmei , Huang Ling , Lei Jia , Yu Xuejing , Wang Xingguo 
Published: August 2021

Abstract
Herbaspirillum camelliae WT00C isolated from tea plant has an intact selenate metabolism pathway but its selenate tolerability is poor. In this study, microbiological properties between the strain WT00C and three strains CT00C, NCT00C and NT00C obtained respectively from 4, 6 and 8 rounds of 24-h exposures to 200 mM selenate were studied and compared. The selenate tolerability and the capability of generating red elemental selenium (Se0) and selenoproteins were significantly improved in H. camelliae WT00C via 4–6 rounds of multiple exposures to high concentration of selenate. The original strain WT00C grew in 200 mM selenate with the lag phase of 12 h and 400 mM selenate with the lag phase of 60 h, whereas the strains CT00C and NCT00C grew in 800 mM selenate and showed quite short lag phase when they grew in 50–400 mM selenate. Two stains also significantly improved the biosynthesis of red elemental selenium (Se0) and selenoproteins besides selenate tolerance. The stains CT00C and NCT00C exhibited more than 30% selenium conversion efficiency and 40% selenoprotein biosynthesis as compared to the original strain WT00C. These characteristics of the strains CT00C and NCT00C make them possible to be applied in pharmaceuticals and feed industries. The strain NT00C obtained from 8 rounds of 24-h exposures to 200 mM selenate was unable to grow in ≥ 400 mM selenate, and its selenium conversion efficiency and selenoprotein biosynthesis were similar to the strain WT00C. Too many exposures caused gene inactivation of some key enzymes involving in selenate metabolism and antioxidative stress. In addition, bacterial cells underwent obviously physiological and morphological changes including gene activity, cell enlargement and surface-roughness alterations during the process of multiple exposures to high concentration of selenate.
Numerical Analysis of An 80,000 Nm3/h Fly Ash Entrained-Flow Gasifier At Various Burner Inclination Angles
Authors: Fang Neng , Zeng Lingyan , Lu Yue , Li Zhengqi , Chen Zhichao 
Published: August 2021

Abstract
The raw syngas effluent from a fluidized bed gasifier typically contains a large amount of fly ash having a high concentration of carbon, which is undesirable. The present work examined the newly developed entrained-flow gasification technology intended to gasify raw syngas. Simulation of gas-solid flow and reaction behavior in an industrial-scale entrained-flow gasifier applying this new technology was first performed to obtain a better understanding of the particle flow and gasification characteristics. In addition, the devolatilization and heterogeneous reactions of fly ash particles were characterized by thermogravimetric analysis and user-defined function. The predictions from the simulation showed good agreement with the results of in situ experimental measurements. The combustion reaction for raw syngas occurred in the burner jet zone. As the hot gaseous products diffused, gasification reactions dominated the other zones. When burner inclination angle was 0°, 8.5°, and 25.5°, the temperature at the bottom outlet of the gasifier was lower than the ash fusion temperature with the value of 1360 °C. Solid slag formed and blocked the outlet. By comparison, this gasifier with the burner inclination angle of 17° could discharge the liquid slag and function as a continuous operation. In this way, the carbon conversion in fly ash reached the maximum value of 89.5%.
Clinical Value of Positive BET and Pelvic Floor Dyssynergia in Chinese Patients with Functional Defecation Disorder
Authors: Jiang Ya , Wang Yan , Tang Yurong , Lin Lin 
Published: August 2021

Abstract
Background
Functional defecation disorder (FDD) is a common subtype of functional constipation (FC). Balloon expulsion test (BET) and high resolution anorectal manometry (HR-ARM) are significant tools but their results are not always consistent.
Aims
To investigate the characteristics of patients with positive BET and pelvic floor dyssynergia (PFD) and explore the value of both positive results in FDD diagnosis.
Methods
We retrospectively diagnose FC subtypes and enrolled FDD patients based on Rome-IV criteria. They underwent HR-ARM, BET and CTT tests. Then they were classified to 2 groups and further stratified by FDD subtypes. Validated questionnaires were applied to investigate patients’ constipation, anxiety/depression and quality of life.
Results
335 FDD patients were finally enrolled. They were classified into 2 groups according to whether BET and PFD were both positive (consistent or not). 84.48% showed consistent results. These patients had significantly higher anal residual pressure, lower anal relaxation rate, MDI and a more negative RAPG (Ps < 0.05). The specific distribution of FDD phenotypes in two groups showed significant difference (P = 0.021). Males suffered a more negative RAPG (P < 0.001) and age was correlated with anal relaxation rate (P < 0.001). 177 individuals among them were investigated with validated questionnaires. Scores for Defecation Symptoms, Physical Discomfort and GAD-7 score were significantly high in Consistent Group (Ps < 0.05). GAD-7 score was associated with Defecation Symptoms (P < 0.001) while anal residual pressure, GAD-7 and Defecation Symptoms score were linked to Physical Discomfort (Ps < 0.05). The diagnostic specificity and PPV for FDD rose significantly with positive BET and PFD.
Conclusion
FDD patients with positive BET and PFD suffer severe defecation symptoms, anxiety and impaired QOL. Positive BET and PFD could be an ideal tool for screening FDD.