bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study
Authors: Kinugasa Eriko , Igawa Ken , Shimada Hisaki , Kondo Morihiro , Funakoshi Satoshi , Imada Naoki , Itami Noritomo , Fukazawa Naoki , Takubo Ryoko , Kawata Yuichi , Murota Hiroyuki 
Published: March 2021

Abstract
Background
The pathophysiology of uremic pruritus (UP), which is characterized by systemic and intractable itching, remains unclear. As interleukin (IL)-31 may be involved, we conducted a phase II, randomized, controlled study to evaluate nemolizumab (anti-IL-31 receptor A antibody) in Japanese hemodialysis patients with UP.

Methods
Patients were randomly assigned (1:1:1:1:1) to one of four double-blind groups (receiving a single subcutaneous injection of nemolizumab 0.125, 0.5, or 2.0 mg/kg, or placebo on Day 1) or an open-label reference group (receiving oral nalfurafine hydrochloride 2.5–5 μg once daily for 12 weeks). The primary endpoint was the difference in the absolute change in pruritus visual analog scale (VAS) at Week 4 between placebo and each nemolizumab group.

Results
The primary efficacy endpoint was not met. The mean change from baseline with all three nemolizumab doses at Week 1, and with 0.5 mg/kg at Week 4, was greater than with placebo. Least square mean differences (95% confidence intervals) in the absolute changes between the placebo arm and each nemolizumab arm were − 2.4 (− 19.7, 14.9) for 0.125 mg/kg, − 8.7 (− 26.6, 9.2) for 0.5 mg/kg, and 0.4 (− 17.0, 17.8) for 2.0 mg/kg. Secondary efficacy parameters including the Shiratori severity score and 5-D itch score failed to show between-group differences. Patients with higher serum IL-31 levels at screening tended to have greater pruritus VAS reductions following nemolizumab treatment.

Conclusions
In this phase II study in patients with UP, the primary efficacy parameter was not met. Nemolizumab was generally well tolerated with no clinically significant safety concerns.

Clinical trial registration
JAPIC: JapicCTI-152961, https://www.clinicaltrials.jp/cti-user/trial/ShowDirect.jsp?japicId=JapicCTI-152961.
An empirical study on changing leadership in agile teams
Authors: Spiegler Simone V. , Heinecke Christoph , Wagner Stefan 
Published: March 2021

AbstractAn increasing number of companies aim to enable their development teams to work in an agile manner. When introducing agile teams, companies face several challenges. This paper explores the kind of leadership needed to support teams to work in an agile way. One theoretical agile leadership concept describes a Scrum Master who is supposed to empower the team to lead itself. Empirical findings on such a leadership role are controversial. We still have not understood how leadership unfolds in a team that is by definition self-organizing. Further exploration is needed to better understand leadership in agile teams. Our goal is to explore how leadership changes while the team matures using the example of the Scrum Master. Through a grounded theory study containing 75 practitioners from 11 divisions at the Robert Bosch GmbH we identified a set of nine leadership roles that are transferred from the Scrum Master to the Development Team while it matures. We uncovered that a leadership gap and a supportive internal team climate are enablers of the role transfer process, whereas role conflicts may diminish the role transfer. To make the Scrum Master change in a mature team, team members need to receive trust and freedom to take on a leadership role which was previously filled by the Scrum Master. We conclude with practical implications for managers, Product Owners, Development Teams and Scrum Masters which they can apply in real settings.
Using Synthetic Adjustments and Controlling to Improve County Population Forecasts from the Hamilton–Perry Method
Authors: Tayman Jeff , Swanson David A. , Baker Jack 
Published: March 2021

AbstractTayman and Swanson (J Popul Res 34(3):209–231, 2017) found in Washington State counties that a forecast based on the Hamilton–Perry method using a synthetic adjustment (SYN) of cohort change ratios and child-woman ratios had greater accuracy and less bias compared to forecasts holding these ratios constant (CONST). In this paper, we assess the robustness of SYN’s efficacy by evaluating forecast accuracy, bias, and distributional error across age groups in counties nationwide. We also investigate whether forecast errors and their patterns change for SYN and CONST if forecasts by age and gender are adjusted to an independent total population forecast for each county. Our main findings are as follows: (1) SYN lowers forecast error compared to CONST whether the forecasts are controlled or not; (2) controlling also leads to the improvements in forecast error, often exceeding those in SYN; and (3) using SYN and controlling together has the greatest effect in reducing forecast error. These findings remain after controlling for population size and growth rate, but the positive impacts on forecast error of SYN and controlling are most evident in counties with less than 30,000 population and that grow by 15% or more.
Putative invasive pulmonary aspergillosis within medical wards and intensive care units: a 4-year retrospective, observational, single-centre study
Authors: Corcione Silvia , Lupia Tommaso , Raviolo Stefania , Montrucchio Giorgia , Trentalange Alice , Curtoni Antonio , Cavallo Rossana , De Rosa Francesco Giuseppe 
Published: March 2021

AbstractBlot and colleagues have proposed putative invasive pulmonary aspergillosis (PIPA) definitions for troublesome diagnosis in suspected patients outside the classical criteria of immunosuppression. We retrospectively included in the study all admitted patients with an Aspergillus spp. positive culture within lower airway samples. Overall, Aspergillus spp. positivity in respiratory samples was 0.97 every 1000 hospital admissions (HA): 4.94 and 0.28/1000/HA, respectively, in intensive care units (ICUs) and medical wards (MW). 66.6% fulfilled PIPA criteria, and 33.4% were defined as colonized. 69.2% of PIPA diagnosis occurred in the ICU. Antifungal therapy was appropriate in 88.5% of subjects with PIPA and 37.5% of colonized, confirming the comparison between deads and lives. Patients with PIPA in the ICUs had more frequent COPD, sepsis or septic shock, acute kidney injury (AKI), needed more surgery, mechanical ventilation (MV), vasopressors, hemodialysis, blood or platelets transfusions. PIPA in MW had associated with a history of smoking, interstitial lung disease and inhaled steroid therapy. Overall mortality within 21 days was 50%: 54.2% in ICU, 36,8% in MW. Factors associated with death were length of hospitalization, influenza, pneumonia, liver transplant, AKI, ARDS, sepsis and septic shock. PIPA in the ICU had higher disease severity and needed more organ support than MW cases, despite that cases of PIPA in MW are emerging with trends difficult to demonstrate given the problematic diagnosis.
A comprehensive KPI network for the performance measurement and management in global production networks
Authors: Verhaelen B. , Mayer F. , Peukert S. , Lanza G. 
Published: March 2021

AbstractThe trend of globalization has led to a structural change in the sales and procurement markets of manufacturing companies in recent decades. In order not to be left behind by this change, companies have internationalized their production structures. Global production networks with diverse supply and service interdependencies are the result. However, the management of global production networks is highly complex. Key performance indicator (KPI) networks already exist at the corporate level and site level to support the management of complex systems. However, such KPI networks are not yet available to support the management of entire production networks. In this article, a KPI network for global production networks is presented, which links the key figures of the site level and the corporate level. By integrating both levels into a comprehensive KPI network, cause and effect relationship between the production-related KPIs and the strategic KPIs of a corporate strategy become transparent. To this end, this KPI network is integrated into a Performance Measurement and Management (PMM) methodology. This methodology consists of three phases: performance planning, performance improvement, and performance review. For testing the practical suitability, the PMM methodology is applied to the production network of an automotive supplier using a simulation model to estimate the effects of proposed improvement actions of the methodology.
Towards a research base for textbooks as teacher support: the case of engaging students in active knowledge organization in the KOSIMA project
Authors: Prediger Susanne , Barzel Bärbel , Hußmann Stephan , Leuders Timo 
Published: March 2021

AbstractEngaging students in processes of mathematizing and active knowledge organization (instead of telling and rehearsing ready-made mathematics) is a key demand for high quality mathematics instruction. Although many mathematically rich context problems have been designed and published in textbooks, their impact on regular mathematics classrooms remains limited, as teachers face challenges in shaping and enacting the important phase of knowledge organization. The 15-year project KOSIMA presented in this paper was aimed at supporting teachers in really enhancing these processes by means of a textbook for Grades 5–10. The paper provides an overview of different studies conducted during the project in order to show how the project developed a research base for the support of teachers. The paper also shows that different research approaches need to be combined to establish an appropriate research base: In iterative design research cycles of topic-specific didactical design research, learning environments were designed and investigated with the aim of understanding the obstacles encountered in implementing the desired processes. In this paper, we focus on an example of one particular obstacle, namely, teachers’ need of support in engaging students in processes of active knowledge organization. This obstacle was overcome by developing new types of tasks for active knowledge organization. The theoretical outcome of the design research resulted in two hypotheses for improving relevant features of the design of these tasks, which were tested in two controlled trials. Finally, a longitudinal field study of 312 students gave first indications that the classes that worked with the textbook had significantly higher learning gains than classes using other textbooks. In sum, we can show that textbooks can support changes in classroom practices when the obstacles that occur for both teachers and students are carefully investigated and treated.
Spectral Estimates for Riemannian Submersions with Fibers of Basic Mean Curvature
Authors: Polymerakis Panagiotis 
Published: March 2021

AbstractFor Riemannian submersions with fibers of basic mean curvature, we compare the spectrum of the total space with the spectrum of a Schrödinger operator on the base manifold. Exploiting this concept, we study submersions arising from actions of Lie groups. In this context, we extend the state-of-the-art results on the bottom of the spectrum under Riemannian coverings. As an application, we compute the bottom of the spectrum and the Cheeger constant of connected, amenable Lie groups.
The Impact of the Livestock Friendly Designation on the Nebraska Cattle Industry: A Difference-in-Difference with Staggered Treatment Analysis
Authors: Dhoubhadel Sunil P. , Azzam Azzeddine 
Published: March 2021

AbstractIn 2003, the Nebraska Legislature enacted the Livestock Friendly County designation program to promote the livestock industry in the state. Forty-nine of the state’s 93 counties received the designation at staggered years. Our paper estimates the causal effect of the program on the state’s cattle industry using a fixed effect difference-in-difference model that accounts for self-selection and staggered designation. Results indicate that the program does not appear to have a statewide effect on livestock expansion, but it is effective in some crop reporting districts. We offer some hypotheses on why this may be the case and draw some policy implications.
Mereological Composition in Analytic and Buddhist Perspective
Authors: JONES NICHOLAOS 
Published: March 2021

AbstractComparing Buddhist and contemporary analytic views about mereological composition reveals significant dissimilarities about the purposes that constrain successful answers to mereological questions, the kinds of considerations taken to be probative in justifying those answers, and the value of mereological inquiry. I develop these dissimilarities by examining three questions relevant to those who deny the existence of composite wholes. The first is a question of justification: What justifies denying the existence of composite wholes as more reasonable than affirming their existence? The second is a question of ontology: Under what conditions are many partless individuals arranged composite-wise? The third is a question of reasonableness: Why, if there are no composites available to experience, do “the folk” find it reasonable to believe there are? I motivate each question, sketch some analytic answers for each, develop in more detail answers from the Theravādin Buddhist scholar Buddhaghosa, and extract comparative lessons.
Normal forms for strong magnetic systems on surfaces: trapping regions and rigidity of Zoll systems
Authors: ASSELLE LUCA , BENEDETTI GABRIELE 
Published: March 2021

AbstractWe prove a normal form for strong magnetic fields on a closed, oriented surface and use it to derive two dynamical results for the associated flow. First, we show the existence of invariant tori and trapping regions provided a natural non-resonance condition holds. Second, we prove that the flow cannot be Zoll unless (i) the Riemannian metric has constant curvature and the magnetic function is constant, or (ii) the magnetic function vanishes and the metric is Zoll. We complement the second result by exhibiting an exotic magnetic field on a flat two-torus yielding a Zoll flow for arbitrarily weak rescalings.
Simulation and flow physics of a shocked and reshocked high-energy-density mixing layer
Authors: Bender Jason D. , Schilling Oleg , Raman Kumar S. , Managan Robert A. , Olson Britton J. , Copeland Sean R. , Ellison C. Leland , Erskine David J. , Huntington Channing M. , Morgan Brandon E. , Nagel Sabrina R. , Prisbrey Shon T. , Pudliner Brian S. , Sterne Philip A. , Wehrenberg Christopher E. , Zhou Ye 
Published: March 2021

Abstract
Glacier clear ice bands indicate englacial channel microbial distribution
Authors: Varliero Gilda , Holland Alexandra , Barker Gary L. A. , Yallop Marian L. , Fountain Andrew G. , Anesio Alexandre M. 
Published: March 2021

AbstractDistant glacial areas are interconnected by a complex system of fractures and water channels which run in the glacier interior and characterize the englacial realm. Water can slowly freeze in these channels where the slow freezing excludes air bubbles giving the ice a clear aspect. This ice is uplifted to the surface ablation zone by glacial movements and can therefore be observed in the form of clear surface ice bands. We employed an indirect method to sample englacial water by coring these ice bands. We were able, for the first time, to compare microbial communities sampled from clear (i.e. frozen englacial water bands) and cloudy ice (i.e. meteoric ice) through 16S rRNA gene sequencing. Although microbial communities were primarily shaped and structured by their spatial distribution on the glacier, ice type was a clear secondary factor. One area of the glacier, in particular, presented significant microbial community clear/cloudy ice differences. Although the clear ice and supraglacial communities showed typical cold-adapted glacial communities, the cloudy ice had a less defined glacial community and ubiquitous environmental organisms. These results highlight the role of englacial channels in the microbial dispersion within the glacier and, possibly, in the shaping of glacial microbial communities.
Do Whisky Investors Read theBible? The Effect of Expert Ratings on the Vintage Single Malt Secondary Market
Authors: Moroz David , Pecchioli Bruno 
Published: March 2021

AbstractThis article aims to estimate the effect of expert assessments on the prices for single malt Scotch whiskies on the investment market. Our results obtained using an original dataset combining data fromJim Murray's Whisky Bibleand a web trading platform specializing in whisky investment show that the quality rating is not a powerful predictor of investor ask prices, especially when controlling for distillery and bottler reputation. This finding suggests that although the Murray score may embed information of use to unsophisticated investors, its effect on price can be outperformed by a detailed knowledge of the whisky industry. (JEL Classifications: L11, L15, Q13)
Analysis of 605 tuberculosis outbreaks in Japan, 1993–2015: time, place and transmission site
Authors: Ota M. , Hoshino Y. , Hirao S. 
Published: March 2021

Abstract
Since 1993, reports on tuberculosis (TB) outbreaks have been collected in Japan; however, there has never been an overall analysis of these TB outbreaks. We aim to provide one here. The TB outbreak data were obtained from the Ministry of Health, Labour and Welfare and are described in terms of time, place and transmission site. The average number of TB cases and latent tuberculosis infection (LTBI) were compared by the transmission site. Some 605 TB outbreaks with 3491 TB cases were reported in 1993–2015 with an increasing trend (r = 0.45), during which time 728 777 TB cases were reported nationwide. On an average, TB outbreaks occurred more often in April to May (5.5 outbreaks per 2 months) than in December to January (3.4). The most common transmission sites were workplaces (n = 255), followed by health facilities (n = 144), schools (n = 60) and welfare facilities (n = 48). Psychiatric hospitals and nursing homes had the highest average number of TB cases per outbreak (8.5 each), whereas schools and prisons had the highest numbers of LTBI cases (29.1 and 38.9, respectively). Countries, particularly those that have resources to investigate TB outbreaks, should collect and analyse findings of TB outbreaks, as it informs surveillance systems and eventually strengthens general health systems.
Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect
Authors: van Oosterhout Jeroen , van der Linden Kim , Simons Claudia J.P. , van Amelsvoort Thérèse , Marcelis Machteld 
Published: March 2021

AbstractNeuroticism is associated with increased stress reactivity. In autism spectrum disorders (ASD), emotional stress reactivity is increased and there is some evidence for an increased negative affect (NA) when with less familiar people. The aim of this study was to compare adults with ASD and controls on levels of neuroticism and on interactions between neuroticism and appraised stress or social context in models of NA. This is a cross-sectional observational study comprising a group of 50 adults with ASD and 51 controls. Experience sampling method (ESM) reports were collected for 10 days to measure daily life stress, mood, and social context. Multilevel regression analyses revealed significantly higher neuroticism levels in ASD than in controls. Adults with ASD who scored high on neuroticism showed a significantly stronger association between activity/social stress and NA (i.e., higher stress reactivity) than those with low scores. Furthermore, the association between neuroticism and NA was stronger when adults with ASD were with less familiar people compared with being alone or with familiar people. No consistent corresponding significant interactions were found in the control group. In conclusion, in ASD, neuroticism moderates the association between appraised stress and NA as well as the association between social context and NA.
Malonyl coenzyme A decarboxylase deficiency with a novel mutation
Authors: Kasapkara Cigdem S. , Civelek Ürey Burcu , Ceylan Ahmet C. , Ünal Uzun Özlem , Çetin Ibrahim İ. 
Published: March 2021

AbstractMalonyl-CoA, a product of acetyl-CoA carboxylase is a metabolic intermediate in lipogenic tissues that include liver and adipose tissue, where it is involved in the de novo fatty acid synthesis and elongation. Malonyl-CoA decarboxylase (MLYCD, E.C.4.1.1.9), a 55-kDa enzyme catalyses the conversion of malonyl-CoA to acetyl-CoA and carbon dioxide, thus providing a route for disposal of malonyl-CoA from mitochondria and peroxisomes, whereas in the cytosol, the malonyl-CoA pool is regulated by the balance of MLYCD and acetyl-CoA carboxylase activities. So far, 34 cases with different MLYCD gene defects comprising point mutations, stop codons, and frameshift mutations have been reported in the literature. Here, we describe the follow-up of a patient affected by malonic aciduria upon neonatal onset. Molecular analysis showed novel homozygous mutations in the MLYCD gene. Our findings expand the number of reported cases and add a novel variant to the repertoire of MLYCD mutations.
School-based interventions for the treatment of childhood obesity: a systematic review, meta-analysis and meta-regression of cluster randomised controlled trials
Authors: Ho Tarcisus Jian Hui , Cheng Ling Jie , Lau Ying 
Published: March 2021

AbstractObjective:Schools offer an ideal setting for childhood obesity interventions due to their access to children and adolescents. This review aimed to systematically review the impact of school-based intervention for the treatment of childhood obesity.Design:Eight databases were searched from inception till 30 May 2020. A revised Cochrane risk-of-bias tool and the Grading of Recommendations, Assessment, Development and Evaluations criteria were used to evaluate the risk of bias and overall evidence. Meta-analysis and meta-regression were performed on Stata software using the random effects model. Overall effect was evaluated using Hedges’ g, and heterogeneity was assessed using Cochran’s Q andI2.Setting:Cluster randomised controlled trials (cluster-RCT) delivered in school.Participants:Children and adolescents (6–18 years of age) with overweight and obesity.Results:Twelve cluster-RCT from seven countries with 1755 participants were included in the meta-analysis. School-based interventions for the treatment of childhood obesity reduced BMI and BMIz-scores with a medium effect (g= 0·52). Subgroup analyses showed greater effectiveness of brief school-based interventions and the interventions conducted in lower-middle to upper-middle economies. Meta-regression assessed the heterogeneity and the final model, with covariates of the type of economies and trial duration, accounted for 41·2 % of the variability. The overall quality of evidence was rated low because of the high risk of bias and inconsistency.Conclusions:School-based interventions are a possible approach to provide universal healthcare for the treatment of childhood obesity, and further well-designed cluster-RCT with longer follow-up are needed. This study is registered with PROSPERO (CRD42020160735).