bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational Climate Factors in Job Creativity among Public University Librarians in Anambra State
Authors: Nwangwu Nneka I. , Etodike Chukwuemeka E. , Okeke Helen C. , Nnaebue Collins I. 
Published: March 2021

Education is the greatest stimulant for human development and the requisite for socio-economic advancement; the utility of libraries in education especially in tertiary institutions are as important as education itself. In third world countries like Nigeria, there is a great disparity in library utility. This study has therefore envisaged that unless librarians are creative given supportive climate, they may not actualize the potentials of libraries given funding inadequacies. Thus, a survey study was carried out utilizing correlation design Pearson correlation statistics to establish the perception of librarians about their organizational climate and whether this perception correlates their creativity. The participants of the study were 89 librarians sampled purposively from University librarians in Anambra State. The questionnaires used for data collection were simplified adaptation of Coveney (2008) and Organizational Climate Questionnaire (OCQ) by Litwin and Stringer (1968). The result indicated that the perception of organizational climate is low among University librarians in Anambra State although the librarians were moderately high on creativity and innovation. Responsibility, reward and support were dimensions of organizational climate which predicted employee creativity whereas organizational identity though impact employees’ creativity but the impact were not of significance proportion. The finding implies that favorable climate to employees helps to stimulate their creative potentials. It is recommended that stakeholder should improve the working climate in University libraries in order to motivate to employees to perform at the highest level bringing their creativity into the organizational dynamics.
The impact of purchasing integration and practices on manufacturing performance
Authors: Narasimhan Ram , Das Ajay 
Published: July 2002

AbstractPurchasing integration remains an under‐researched concept, despite being described as a key competence in the literature. This study explicates the concept of purchasing integration and examines its relationships with purchasing practices and manufacturing performance. Purchasing integration refers to the integration of strategic purchasing practices and goals with a firm’s objectives. Alternative models linking purchasing integration to purchasing practices and manufacturing performance are hypothesized and tested using empirical data. Purchasing integration was found to moderate the relationship between purchasing practices and manufacturing performance. Increased investments in purchasing integration were observed to lead to higher performance returns from investments in purchasing practices.
The service concept: the missing link in service design research?
Authors: Goldstein Susan Meyer , Johnston Robert , Duffy JoAnn , Rao Jay 
Published: July 2002

AbstractThe service concept plays a key role in service design and development. But while the term is used frequently in the service design and new service development literature, surprisingly little has been written about the service concept itself and its important role in service design and development. The service concept defines the how and the what of service design, and helps mediate between customer needs and an organization’s strategic intent. We define the service concept and describe how it can be used to enhance a variety of service design processes. As illustrations here, we apply the service concept to service design planning and service recovery design processes. Employing the service concept as an important driver of service design decisions raises a number of interesting questions for research which are discussed here.
The impact of market requirements focus and manufacturing characteristics focus on plant performance
Authors: Bozarth Cecil , Edwards Steve 
Published: July 2002

AbstractThis study examines the relationship between market requirements focus, manufacturing characteristics focus, and manufacturing performance. Results from a sample of plants serving the automotive industry support the general argument that market requirements focus and manufacturing characteristics focus have an impact on manufacturing performance, and provide partial support for a mediation model of focus proposed by Bozarth (1993). The results also show that focused work cells or plants‐within‐a‐plant might not be entirely successful at buffering plants from the negative impact of diverse market requirements.
Operations management research: an update for the 1990s
Authors: Pannirselvam Gertrude P , Ferguson Lisa A , Ash Robert C , Siferd Sue P 
Published: July 2002

AbstractThe issue of operations management (OM) research agendas was first advanced in the literature in 1980 with updates and additions in 1981, 1987, and 1989. We believe that the time is ripe for an analysis of the OM research agenda in the decade of the 90's. In this study, we examine operations management research methodologies and output during the period 1992–1997. Amoako‐Gyampah and Meredith [Amoako‐Gyampah, K., Meredith, J.R., 1989. Journal of Operations Management 8, 250‐262] published a study in which they examined operations management research output from 1982 through 1987. Our objectives are to examine the state of operations management research in the 1990s from the standpoint of topics and methodologies to look for trends, and to determine implications for future research. We assessed the state of research in operations management by examining the research topics addressed and the methodologies used in a subset of seven academic journals that are representative of publications in operations management research. We also surveyed pipeline research in the operations management area by analyzing the topics discussed in national conferences attended by operations management academicians and researchers. Our findings show some significant changes in the kind of research being performed in the 1990s vs. the 1980s. Greater interest in strategy and quality are now apparent in the literature. OM research in the 1990s is also more integrative in nature. We were surprised to find no apparent shift away from modeling solution methods nor any significant shift toward empirical methodologies.
The diagnostic stability of ICD-10 psychiatric diagnoses in clinical practice
Authors: Daradkeh TK , El-Rufaie OEF , Younis YO , Ghubash R 
Published: July 2002

SummaryThis study examines the stability of ICD-10 diagnoses of patients admitted to Al Ain (United Arab Emirates) inpatients psychiatric unit during the period from November 1993 to August 1995. Diagnostic stability is a measure of the degree to which diagnoses remained unchanged at a later hospital admission. One hundred and seven patients were admitted more than once during this period, accounting for 168 readmissions. High levels of diagnostic stability were found for ICD-10 Fl-psychiatric disorders (100%), F2-schizophrenia (87%), F3-bipolar disorders (87%) and F3-depressive disorders (73%). A poor level of stability was found for patients with neurotic, stress related and adjustment disorders (F4), ranging from zero for somatoform disorders to 50% for generalized anxiety and panic disorders. Poor levels of stability were also found for other psychoses (excluding schizophrenia and affective psychoses) and personality disorders. We conclude that the introduction of ICD-10 as a formal diagnostic system has greatly improved the temporal stability of the most commonly encountered psychiatric disorders (ICD-10 Fl to F3 disorders), confirming the construct validity of those psychiatric disorders. Further investigations are required to evaluate the diagnostic stability of neurotic and other psychotic disorders.
First‐dose hypotension after angiotensin‐converting enzyme (ACE) inhibitors in chronic heart failure: a comparison of enalapril and perindopril
Authors: Vítovec Jirí , Špinar Jindrich ,   Czech and Slovak Investigator Group
Published: July 2002

AbstractBackground:First‐dose hypotension refers to an observed reduction in blood pressure after the administration of the first dose of ACE inhibitors in patients with congestive heart failure.Aim:To compare the first‐dose responses of low‐dose enalapril and perindopril in patients with stable symptomatic chronic heart failure.Methods:Single blind, randomised, multicenter, parallel, prospective study. Patients (N = 298) with chronic heart failure due to ischemic heart disease or dilated cardiomyopathy, NYHA II–IV, ejection fraction < 40%, age > 18 years, naive to ACE inhibitors or ATI‐receptor blocker, were randomised to receive a single dose of 2.5 mg enalapril or 2.0 mg perindopril. Baseline laboratory and clinical examinations were performed before entry into the study. Ambulatory blood pressure monitoring started 2 h before the study medication was given, and continued for at least 10 h after the medication.Results:The maximum drop in blood pressure appeared approximately 4 h after dose administration in both groups, and was more pronounced in the enalapril group. Patients in the enalapril group had a significantly higher incidence of asymptomatic hypotension. No symptomatic hypotension requiring a change in medication or a prolongation of hospitalisation was observed.Conclusion:A low dose of perindopril is well‐tolerated at initiation of ACE inhibitor therapy in patients with chronic heart failure and causes less first‐dose hypotension than a low dose of enalapril.
Nanostructured Multilayer Coatings for Spatial Filtering
Authors: Grineviciute Lina , Babayigit Ceren , Gailevičius Darius , Peckus Martynas , Turduev Mirbek , Tolenis Tomas , Vengris Mikas , Kurt Hamza , Staliunas Kestutis 
Published: March 2021

AbstractSpatial filtering is an important mechanism to improve the spatial quality of laser beams. Typically, a confocal arrangement of lenses with a diaphragm in the focal plane is used for intracavity spatial filtering. Such conventional filtering requires access to the far‐field domain. In microlasers, however, conventional filtering is impossible due to the lack of space in microresonators to access the far‐field. Therefore, a novel concept for more compact and efficient spatial filtering is necessary. In this study, a conceptually novel mechanism of spatial filtering in the near‐field domain is proposed and demonstrated, by a nanostructured multilayer coating—a 2D photonic crystal structure with a periodic index modulation along the longitudinal and transverse directions to the beam propagation. The structure is built on a nanomodulated substrate, to provide the transverse periodicity. The physical vapor deposition is used to provide self‐repeating modulation in the longitudinal direction. A 5 µm thick photonic multilayer structure composed of nanostructured multiple layers of alternating high‐ and low‐index materials providing spatial filtering in the near‐infrared frequencies with 2° low angle passband is experimentally demonstrated. The proposed photonic structure can be considered as an ideal component for intracavity spatial filtering in microlasers.
Phosphorus‐Directed C−H Borylation
Authors: Auth Marin R. , McGarry Kathryn A. , Clark Timothy B. 
Published: March 2021

AbstractPhosphorus‐containing compounds have a long history of utility in a broad range of fields, including agricultural, pharmaceutical, and metal‐mediated reactions. In recent decades, numerous methods have been developed to streamline the synthesis of organophosphorus reagents based on these numerous applications. This review focuses upon the recent development of phosphorus(III)‐ and phosphorus(V)‐directed C−H borylation reactions. This transformation has evolved significantly in the past two years, resulting in several new methods that provide access to organic substrates containing both phosphorus and boron. Further functionalization of the carbon−boron bond to provide functionalized organophosphorus products is discussed.magnified image
Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor
Authors: Gong Changguo , Zhang Xiao , Shi Min , Li Feng , Wang Shuang , Wang Yan , Wang Yugang , Wei Wei , Ma Guanghui 
Published: March 2021

AbstractAs membrane‐bound extracellular vesicles, exosomes have targeting ability for specific cell types, and the cellular environment strongly impacts their content and uptake efficiency. Inspired by these natural properties, the impacts of various cellular stress conditions on the uptake efficiency of tumor iterated exosomes are evaluated, and low‐pH treatment caused increased uptake efficiency and retained cell‐type specificity is found. Lipidomics analyses and molecular dynamics simulations reveal a glycerolipid self‐aggregation‐based mechanism for the enhanced homologous uptake. Furthermore, these low‐pH reprogrammed exosomes are developed into a smart drug delivery platform, which is capable of specifically targeting tumor cells and selectively releasing diverse chemodrugs in response to the exosome rupture by the near‐infrared irradiance‐triggered burst of reactive oxygen species. This platform exerts safe and enhanced antitumor effects demonstrated by multiple model mice experiments. These results open a new avenue to reprogram exosomes for smart drug delivery and potentially personalized therapy against their homologous tumor.
Smart Cargo Delivery System based on Mesoporous Nanoparticles for Bone Disease Diagnosis and Treatment
Authors: Pan Panpan , Yue Qin , Li Juan , Gao Meiqi , Yang Xuanyu , Ren Yuan , Cheng Xiaowei , Cui Penglei , Deng Yonghui 
Published: March 2021

AbstractBone diseases constitute a major issue for modern societies as a consequence of progressive aging. Advantages such as open mesoporous channel, high specific surface area, ease of surface modification, and multifunctional integration are the driving forces for the application of mesoporous nanoparticles (MNs) in bone disease diagnosis and treatment. To achieve better therapeutic effects, it is necessary to understand the properties of MNs and cargo delivery mechanisms, which are the foundation and key in the design of MNs. The main types and characteristics of MNs for bone regeneration, such as mesoporous silica (mSiO2), mesoporous hydroxyapatite (mHAP), mesoporous calcium phosphates (mCaPs) are introduced. Additionally, the relationship between the cargo release mechanisms and bone regeneration of MNs‐based nanocarriers is elucidated in detail. Particularly, MNs‐based smart cargo transport strategies such as sustained cargo release, stimuli‐responsive (e.g., pH, photo, ultrasound, and multi‐stimuli) controllable delivery, and specific bone‐targeted therapy for bone disease diagnosis and treatment are analyzed and discussed in depth. Lastly, the conclusions and outlook about the design and development of MNs‐based cargo delivery systems in diagnosis and treatment for bone tissue engineering are provided to inspire new ideas and attract researchers’ attention from multidisciplinary areas spanning chemistry, materials science, and biomedicine.
Direct Visualization and Effects of Atomic‐Scale Defects on the Optoelectronic Properties of Hexagonal Boron Nitride
Authors: Ares Pablo , Santos Hernán , Lazić Snežana , Gibaja Carlos , Torres Iñigo , Pinilla Sergio , Gómez‐Herrero Julio , van der Meulen Herko P. , García‐González Pablo , Zamora Félix 
Published: March 2021

AbstractHexagonal boron nitride (hBN) has attracted a lot of attention in the past years, thanks to its many remarkable properties. These include the presence of single‐photon emitters with superior optical properties, which make it an ideal candidate for a plethora of photonic technologies. However, despite the large number of experimental results and theoretical calculations, the structure of the defects responsible for the observed emission is still under debate. In this work, individual atomic‐scale defects in hBN with atomic force microscopy under ambient conditions are visualized and multiple narrow emission lines from optically stable emitters are observed. This direct observation of the structure of the defects combined with density functional theory calculations of their band structures and electronic properties allows associating the existence of several single‐photon transitions to the observed defects. The work sheds light on the origin of single‐photon emission in hBN that is important for the understanding and tunability of high‐quality emitters in optoelectronics and quantum technologies.
Interseeding annual warm‐season grasses into pastures: Forage nutritive value and yields
Authors: Guretzky John A. , Harmoney Keith R. , Moyer Joseph L. , Volesky Jerry D. , Stephenson Mitchell B. 
Published: March 2021

AbstractInterseeding annual warm‐season grasses into pastures often increases forage accumulation. Yet, impacts on nutritive value and yields remain unreported. We analyzed forage collected from five Nebraska and Kansas experiments in 2015–2016 (eight environments) for crude protein (CP), neutral detergent fiber (NDF), and in vitro organic matter digestibility (IVOMD) concentrations and yields. Each experiment subjected perennial cool‐season grasses to two harvest frequencies (once at 90 d and twice at 45 and 90 d after interseeding) and four interseeded annual warm‐season grass types–pearl millet [Pennisetum glaucum (L.) R. Br.], sudangrass [Sorghum bicolor (L.) Moench ssp. drummondii (Nees ex Steud) de Wet & Harlan], a sorghum–sudangrass hybrid (S. bicolor × S. bicolor var. sudanense), and an unseeded control. Across environments, 90‐d CP and IVOMD concentrations increased while CP and IVOMD yields decreased in interseeded pastures when harvested twice, indicating presence of nutritive value‐yield tradeoffs. Pastures interseeded with sorghum–sudangrass had greater 90‐d IVOMD concentrations and CP and IVOMD yields when harvested once but only greater 90‐d IVOMD concentrations when harvested twice compared to unseeded pastures. Interseeding sorghum–sudangrass provided an effective strategy to increase CP and IVOMD yields in late summer in humid environments with tall fescue [Schedonorus arundinaceus (Schreb.) Dumort., nom. cons.] and in mid‐ and late summer in humid environments with smooth bromegrass (Bromus inermis Leyss.) and semiarid environments with western wheatgrass [Pascopyrum smithii (Rydb.) Á. Löve]. Interseeding annual warm‐season grasses did not consistently increase CP and IVOMD yields in semiarid environments with smooth bromegrass and crested wheatgrass [Agropyrum cristatum (L.) Gaertn.].
Combination of CD19 and CD22 CAR‐T cell therapy in relapsed B‐cell acute lymphoblastic leukemia after allogeneic transplantation
Authors: Liu Shuangyou , Deng Biping , Yin Zhichao , Lin Yuehui , An Lihong , Liu Dan , Pan Jing , Yu Xinjian , Chen Bingzhen , Wu Tong , Chang Alex H. , Tong Chunrong 
Published: March 2021

AbstractThe prognosis of relapsed acute lymphoblastic leukemia (ALL) after allogeneic transplantation is dismal when treated with conventional approaches. While single‐target CD19 or CD22 chimeric antigen receptor (CAR) T‐cell therapy has achieved high complete remission (CR) rates in refractory/relapsed B‐ALL, it could not maintain a durable remission in most patients. To prolong relapse‐free survival, we sequentially combined CD19 and CD22 CAR‐T cells to treat post‐transplant relapsed B‐ALL patients with both CD19/CD22 antigen expression on lymphoblasts. Patient‐derived donor cells were collected to produce CAR‐T cells that were transfected by lentiviral vectors encoding second generation CARs composed of CD3ζ and 4–1BB. The second T‐cell infusion was scheduled at least 1 month, and usually within 6 months after the first CAR‐T treatment. Twenty‐seven adult and pediatric patients, including 11 (41%) with extramedullary diseases (EMD), received the first CD19 CAR‐T and 23 (85%) achieved CR. Subsequently, 21 out of 27 patients received the second CD22 CAR‐T and were followed‐up for a median of 19.7 (range, 5.6–27.3) months; 14 cases remained in CR, seven relapsed and two of them died from disease progression; Kaplan–Meier survival analysis showed overall survival and event‐free survival rates of 88.5% and 67.5%, respectively, at both 12 months and 18 months. CAR‐T associated graft‐versus‐host disease (GVHD) occurred in 23% of patients, with 8% new‐onset acute GVHD and 15% persistent or worsened pre‐existing cGVHD before CAR‐T. This combination strategy of sequential CD19 and CD22 CAR‐T therapy significantly improved the long‐term survival in B‐ALL patients who relapsed after transplantation.
National patterns of injury and outcomes of gunshot wounds to the penis: A Trauma Quality Programs retrospective cohort analysis
Authors: Maxwell Bryan G. , Chouhan Jyoti D. , Lundeberg Megan R. , Liu Jen‐Jane 
Published: March 2021

AimGunshot wounds (GSW) to the penis represent a rare type of traumatic injury in the civilian United States population. Although small, single‐center studies have reported results of care for these types of injured patients, no national analyses have examined this group.MethodsA cohort of patients with GSW to the penis was identified using the 2017 American College of Surgeons Trauma Quality Programs database, a comprehensive national database of 753 accredited trauma centers.ResultsGunshot wounds to the penis occurred in 722 patients, which represents 1.7% of all GSW patients (n = 41,017). Gunshot wounds from altercations with law enforcement or accidental discharge of a firearm were rare; the vast majority (n = 655, 90.7%) occurred as a result of assault, intentional self‐harm, attempted suicide, or attempted homicide. Patients with a major concomitant non‐genitourinary injury comprised 119 (16.5%) patients of the cohort. Most patients (n = 499, 69.1%) underwent a genitourinary procedure during their trauma admission. Penile salvage was successful in most cases, with only 13 (1.8%) patients requiring completion penectomy. Most patients (87.8%) required admission with a median length of stay of 49.8 h. Most patients were treated at the initial trauma center without requiring transfer to another center, and complications during admission were rare.ConclusionsThis analysis, the first national examination of care of patients with GSW to the penis, reveals overall favorable outcomes. Admission and surgical intervention were required in most patients, but penectomy was rare and length of stay was generally short. These results will guide resource utilization and quality improvement efforts in this patient cohort.