bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptotic Limit-cycle Analysis of Oscillating Chemical Reactions
Authors: Brizard Alain , Berry Samuel 
Published: June 2021

Abstract
The asymptotic limit-cycle analysis of mathematical models for oscillating chemical reactions is presented. In this work, after a brief presentation of mathematical preliminaries applied to the biased Van der Pol oscillator, we consider a two-dimensional model of the Chlorine dioxide Iodine Malonic-Acid (CIMA) reactions and the three-dimensional and two-dimensional Oregonator models of the Belousov-Zhabotinsky (BZ) reactions. Explicit analytical expressions are given for the relaxation-oscillation periods of these chemical reactions that are accurate within 5% of their numerical values. In the two-dimensional CIMA and Oregonator models, we also derive critical parameter values leading to canard explosions and implosions in their associated limit cycles.
Can The Timing And Duration of Planktonic Larval Development Determine Invasion Success? A Case Study Comparing Range Expansion In The European Green Crab, Carcinus Maenas, And The Native Lined Shore Crab, Pachygrapsus Crassipes, In The North-Eastern Pacific.
Authors: Yamada Sylvia Behrens , Shanks Alan L. , Thomson Richard E. 
Published: June 2021

Abstract
Major El Niño events and oceanic heat waves are linked to the range expansion of many marine species. For the shores of the northeast Pacific, we compared range expansion in the European green crab, Carcinus maenas, which was introduced to San Francisco Bay prior to 1990, to that of the native lined-shore crab, Pachygrapsus crassipes, which has existed on the coast since at least the end of the last Ice Age (>10,000 years ago). The initial northern range limit of these species was central California and central Oregon, respectively. Both species increased their northern range along the open coast to northern Oregon, Washington and Vancouver Island after strong El Niño events. C. maenas, however, in just a matter of decades, successfully established populations in inlets on the west coast of Vancouver Island, and possibly also in the Salish Sea, while P. crassipes, in thousands of years, never has. We hypothesize that this difference in invasion success is due to the shorter larval duration of C. maenas, < 2 months, compared to that of P. crassipes, 3-4 months and timing of larval release, winter for both species. Because the residency times of water in the inlets of the west coast of Vancouver Island are ~1-2 months, they can act as an incubator for the larvae of C. maenas, while those of P. crassipes are likely flushed out to the open sea before they can complete their development.
Effects of Cropping Practice on Bupleurum Chinense Rhizosphere Microbial Community
Authors: Liu Li , Cao Hailu , Geng Yannan , Fan Ya , Feng Haiyang , Du Kan , Bu Xun , Gao Demin 
Published: June 2021

Abstract
It is of great importance to understand the effects of cropping practices of Bupleurum chinense on the properties of rhizosphere soil. Therefore, the chemical properties of rhizosphere soil and the rhizosphere microbiome were assessed in the field trial with Bupleurum and three cropping practices (continuous monocropping, Bupleurum-corn intercropping and Bupleurum-corn rotation). The results showed cropping practices changed the chemical properties of the rhizosphere soil and composition, structure and diversity of the rhizosphere microbial communities. Continuous monocropping of Bupleurum chinense not only decreased soil pH and the contents of NO3--N and available K, but also decreased the alpha diversity of bacteria and beneficial microorganisms. However, Bupleurum-corn rotation improved soil chemical properties and reduced the abundance of harmful microorganisms. Soil chemical properties, especially the contents of NH4+-N, soil organic matter (SOM) and available K, were the key factors affecting the structure and composition of microbial communities in the rhizosphere soil. These findings could provide a new basis for overcoming problems associated with continuous cropping and promote development of B. chinense planting industry by improving soil microbial communities.
The Impact of Sex Chromosome Trisomies (XXX, XXY, XYY) on Social Attention and Affect Recognition: A Cross-Sectional Eye Tracking Study
Authors: Bouw Nienke , Swaab Hanna , Tartaglia Nicole , Cordeiro Lisa , Rijn Sophie van 
Published: June 2021

Abstract
Background

About 1:650–1000 children are born with an extra X or Y chromosome (47,XXX; 47,XXY; 47,XYY), which results in a Sex Chromosome Trisomy (SCT). This international cross-sectional study was designed to investigate social attention and affect recognition during early life of children with SCT, with the aim to find indicators for support and treatment.
Methods

A group of 101 children with SCT (aged 1–7 years old; Mage= 3.7 years) was included in this study, as well as a population-based sample of 98 children without SCT (Mage= 3.7). Social attention was measured using an eye tracking method that quantifies first fixations and fixation durations on eyes of static faces and fixation durations on social information (eyes, faces) in a dynamic paradigm (with two conditions: single face and multiple faces). Affect recognition was measured using the subtest Affect Recognition of the NEPSY-II neuropsychological test battery. Recruitment and assessment took place in the Netherlands and the United States.
Results

Eyetracking results reveal that children with SCT show lower proportions fixation duration on social information already from the age of three years, compared to children without SCT. Also, impairments in the clinical range for affect recognition were found (32.2% of the SCT group scored in the well below average range); these difficulties increase with age.
Conclusions

These results highlight the importance to further explore the development of social cognition skills of children with SCT in a longitudinal design, the monitoring of affect recognition skills, and the implementation of (preventive) interventions aiming to support the development of social attention and affect recognition.
Effects of Soybean and Rice Bran Oil Supplementation on Nutrient Utilization, Lactation Performance, Milk Fatty Acid Profile and Ruminal Fermentation in Surti Goats
Authors: Raval Ajay Prahladbhai , Patel Vipul R , Sorathiya Lalitchandra M , Movalia Jignesh K 
Published: June 2021

Abstract
A study was conducted to observe the effect of soybean and rice bran oil supplementation onnutrient utilization, lactation performance and ruminal fermentation in Surti goats. Twentyfour multiparous lactating Surti does were distributed into four homogenous groups for entirelactation of 150 days. Control group (CON) was offered a basal diet consisting of compoundconcentrate mixture, green jowar and pigeon pea straws without any oil supplementation,while other treatment groups were additionally supplemented with soybean oil @ 3% of DMI(SBO), rice bran oil @ 3% of DMI (RBO) and equi-propotional blend of soybean oil and ricebran oil @ 3.0 % of DMI (SRBO). DM, CP, NDF and ADF intake (g/d) and digestibility (%)remained statistically (p>0.05) similar amongst dietary treatments groups. EE intake (g/d)and digestibility (%) was significantly (p<0.01) improved in all three oils supplementedgroups as compared to control but values between oils supplemented groups remained at par(p>0.05). Nitrogen balance of experimental groups remained unaffected (p>0.05) and all theanimals were under positive nitrogen balance. Milk yield (kg/d), milk fat, SNF, protein,lactose, FCM and ECM yields (g/d) were significantly (p<0.05) increased in oilssupplemented groups as compared to control. Feed efficiency in terms of MY/DMI andFCM/DMI significantly (p<0.05) improved in SBO, RBO and SRBO as compared to CON.Soybean and rice bran oil supplementation either alone or in combination significantlyreduced (p<0.05) SCFA, MCFA, SFA with increased LCFA and PUFA in milk. However,values between oils supplemented groups remained at par (p>0.05). Oil supplementationincreased (p<0.001) oleic acid (C18:1 n-9) and linoleic acid (C18:2 n-6) in SBO, RBO andSRBO as compared to CON while, linolenic acid (C18:3 n-9) remained non significantamongst treatments. Lipid quality indices (LQI) like atherogenicity index, thrombogenicityindex and hypocholesterolaemic/hypercholesterolaemic (h/H) index were significantlyimproved in all the oils supplemented groups as compared to control. Rumen pH, totalnitrogen and its fractions (ammonia N, TCA precipitable N and soluble N) remained similar(p>0.05) amongst treatment except TVFA. Thus, supplementation of soybean oil and ricebran oil either alone or in combination in lactating goat can be effectively used to improveboth nutritional quantity and quality of milk.
Granular flow experiment using artificial gravity generator on International Space Station
Authors: Ozaki Shingo , Ishigami Genya , Otsuki Masatsugu , Miyamoto Hirdy , Wada Koji , Watanabe Yutaro , Nishino Takaru , Kojima Hiromichi , Soda Keinosuke , Nakao Yuki , Sutoh Masataku , Maeda Takao , Kobayashi Taizo 
Published: June 2021

Abstract
Studying the gravity-dependent characteristics of regolith, fine-grained granular media covering extra-terrestrial bodies is essential for the reliable design and analysis of landers and rovers for space exploration. We performed a granular flow experiment under stable artificial gravity conditions generated by a centrifuge on the International Space Station. We also performed a discrete element simulation of the granular flow in both artificial and natural gravity environments. The simulation results verified that the granular flows in artificial and natural gravity are consistent. Further, regression analysis of the granular flow results revealed that the mass flow rate quantitatively follows a well-known physics-based law with some deviations under low-gravity conditions, implying that the bulk density of the granular media decreases with gravity. This insight also indicates that the bulk density considered in simulation studies of space probes under low-gravity conditions needs to be tuned for their reliable design and analysis.
Orai1 Downregulation Causes Proliferation Reduction and Cell Cycle Arrest via Inactivation of the Ras-NF-κB Signaling Pathway in Osteoblasts
Authors: Guo Yunshan , Hao Dingjun 
Published: June 2021

Abstract
Objective: The purpose of this study was to determine the role of Orai1 in the regulation of the proliferation and cell cycle of osteoblasts. Methods: The expression of Orai1 was inhibited by Orai1 small interfering RNA (siRNA) in MC3T3-E1 cells. Following Orai1 downregulation, cell proliferation and cell cycle were examined. Furthermore, the expression of cyclin D1, cyclin E, CDK4, and CDK6 was analyzed. The activity of the Ras-NF-κB signaling pathway was investigated to identify the role of Orai1 in the regulation of osteoblast proliferation. Results: Orai1 was successfully downregulated in MC3T3-E1 cells by the Orai1 siRNA transfection (p <0.05). We found that MC3T3-E1 cell proliferation was decreased, and the cell cycle was arrested by Orai1 downregulation (p <0.05). Additionally, the expression of cyclin D1 was decreased by Orai1 downregulation (p <0.05), as was the activity of the Ras-NF-κB signaling pathway (p <0.05). Orai1 siRNA did not further reduce cell proliferation, the proportion of cells in the S phase, and cyclin D1 expression after chemical blockage of the Ras signaling pathway in MC3T3-E1 cells (p >0.05).Conclusion: The results reveal that Orai1 downregulation may reduce cyclin D1 expression by inactivating the Ras-NF-κB signaling pathway thus blocking osteoblast proliferation and cell cycle.
Biomechanics of Calcaneus Impacted by Talus: A Dynamic Finite Element Analysis
Authors: Huang Mengquan , Yu Bin , Li Yubiao , Liao Chunlai , Peng Jun , Guo Naiming 
Published: June 2021

Abstract

BackgroundThe biomechanics of calcaneus impacted by the talus are unclear. We aimed to evaluate the biomechanical effect of the talus impacting on the calcaneus at different falling speed, and analyze the factors affecting calcaneal fracture.Methods A finite element model including the talus, calcaneus and ligaments was built using a variety of three-dimensional reconstruction software. The method of explicit dynamics was used to analyze the process of the talus impacting the calcaneus. Stress values of the posterior, middle, and anterior subtalar articular surface(PSAS, ISAS, ASAS), the calcaneocubic articular surface(CAS), the bottom of the calcaneus(BC), the medial wall (MW)and lateral wall (LW) of the calcaneus were extracted. Stress quantity and distribution changes in various parts of the calcaneus changed with speed were analyzed.ResultsPosterior subtalar articular surface reached the peak stress first during the process of talus impacting the calcaneus. The stress was mainly concentrated on the PSAS, ASAS, MW and GA. Comparing with the speed of 5m/s, the average maximum stress increased in each region of the calcaneus were: PSAS 73.81%, ISAS 7.11%, ASAS 63.57%, GA 89.10%, LW 140.16%, CAS 140.58%, BC 137.67%, MW 135.99% at a speed of 10m/s. The regions where the stress were concentrated changed, and the magnitude and sequence of stress peaks of calcaneus changed with speed also during the impact.Conclusion The falling speed affected the value and distribution of stress of the calcaneus, which was the most important factor leading to a calcaneal fracture. The magnitude and sequence of stress peaks might be important factors in determining the beginning and direction of fracture lines.
Diarrhea Duration and Performance Outcomes of Pre-Weaned Dairy Calves Supplemented with Bacteriophage
Authors: Schmoeller Evandro , de Matos Adriane D. C. , RAHAL NATALIA , Feijo Josiane O. , Brauner Cassio C. , Pino Francisco Augusto B. Del , Correa Marcio N. , Rabassa Viviane R. 
Published: June 2021

Abstract
This study aimed to evaluate lytic bacteriophage supplementation in pre-weaned dairy calves over neonatal calf diarrhea and respiratory diseases occurrence, performance and biochemical parameters. Also, to determine bacterial agents causing NCD. Two hundred Holstein×Gyr crossbred female calves were divided into two groups: Control (CON, n = 100), no supplementation; and Bacteriophage (PHAGE, n = 100) bacteriophage supplementation (1 g/day) from d 3 until d 70 of life. Calves were monitored daily for respiratory disease and diarrhea, as for age at the first diarrheic episode and its duration. Fecal samples were cultured for isolation of Escherichia coli and Salmonella spp. colonies and PCR was performed to identify E. coli virulence genes and to confirm Salmonella spp. Performance outcomes were evaluated up to 80 d of age. Blood samples were collected to determine serum levels of total proteins, albumin, cholesterol, γ-glutamyl transferase and urea. PHAGE group had fewer days in diarrhea and duration of the first episode was lower, compared to CON group. Fecal samples of three animals in PHAGE and nine in CON were positive for E. coli in PCR. Thoracic perimeter tended to be higher in supplemented animals. Average daily gain mean of PHAGE was higher in the first 30 d of life, at the beginning of step-down weaning (up to 42 d) and after weaning (up to 80 d). PHAGE mean was lower for albumin and higher for urea. Therefore, phage therapy during the pre-weaned period reduced the duration of neonatal diarrhea, providing greater weight gain for calves.
Obstetric Outcomes After Perforation of Uterine Cavity
Authors: Schwarzman Polina , Baumfeld Yael , Mastrolia Salvatore Andrea , Yaniv-Salem Shimrit , Leron Elad , Silberstein Tali 
Published: June 2021

Abstract
Purpose: We aimed to evaluate the pregnancy characteristics and obstetric outcomes in patients after perforation of uterus.Study design: A retrospective, case control study was conducted and included all patients who were diagnosed with uterine perforation and treated in a tertiary referral medical center between the years 1996 to 2018. Up to two deliveries after perforations were investigated.Results: During the study period, 51 women were diagnosed with uterine perforation during gynecological procedures, including intrauterine device (IUD) insertion. The mean age of patients at the time of diagnosis was 27.9 (±4.7) years. The majority, 76.5% (n=39), experienced perforation during IUD insertion, and 23.5% (n=12) of the patients experienced perforation during surgical procedures. Most of the patients were multiparous or grand multiparous, 45.8. % (n=22) and 39.6% (n=19) respectively. Anteflexed uterus found in 86.4% of patients (n=38). Five patients (9.8%) had pelvic abscesses after the IUD insertion. 50 patients had 71 deliveries subsequent the uterine perforation. One patient had intrauterine fetal death due to fetal malformations. One patient had uterine rupture. No other major obstetric complications were noted.Conclusion: Uterine perforation may impair obstetric outcomes; the possibility of uterine rupture must be considered while managing deliveries of patients post uterine perforation.
Distinction of Consciousness Fields According to Taheri from Other Conventional Physical Fields: Evaluating the Magnetic Properties of Materials
Authors: Taheri Mohammad , Payervand Forouz , Ahmadkhanlou Farzad , Torabi Sara , Semsarha Farid 
Published: June 2021

Abstract
Magnetization hysteresis loop provides important information about the magnetic properties of materials. In this study, by examining the magnetic properties of three paramagnetic and diamagnetic materials in the vicinity of the Consciousness Fields (three types 1,2 and 3), we have investigated the nature of the Consciousness Fields in comparison with magnetic field. The magnetic properties of the materials under the influence of three distinct Consciousness Fields have changed significantly. Furthermore, the Consciousness Field 1 of the present study (with originally named Faradarmani by Taheri) has changed the magnetic properties of materials toward their physically inherent state in standard laboratory conditions. Based on the conditions and the results of the present study, it can be concluded that the Consciousness Fields are inherently neither electric nor magnetite fields and have a completely different and distinct impact on materials and their properties.
Measurement and Modeling of Clemastine Fumarate (Antihistamine Drug) Solubility in Supercritical Carbon Dioxide
Authors: Sodeifian Gholamhossein , Garlapati Chandrasekhar , Razmimanesh Fariba , Ghanaat-Ghamsari Marziehsadat 
Published: June 2021

Abstract
The solubilities of clemastine fumarate in supercritical carbon dioxide) ScCO2( were measured for the first time at temperature (308 to 338 K) and pressure (12 to 27 MPa). The measured solubilities were reported in terms of mole faction and it is ranged from 1.61 ×10− 6 to 9.41×10− 6. Various models were used to correlate the data. The efficacy of the models was quantified with corrected Akaike’s information criterion (AICc). A new cluster salvation model was derived to correlate the solubility data. The new model was able to correlate the data and deviation was 10.3% in terms of average absolute relative deviation (AARD). Furthermore, the measured solubilities were also correlated with existing K.-W. Chen et al., cluster salvation model, equation of state (EoS) model and few density models. Among density models, Tippana and Garlapati model was observed to be the best model and corresponding AARD% was 7.57 (corresponding AICc is -678.88). The Peng-Robinson equation of state as temperature independent was able to correlate the data and deviation was 8.25% in terms of AARD% (corresponding AICc is -674.88). Moreover, thermodynamic enthalpies of clemastine fumarate were estimated.
Benefit of Adjuvant Chemotherapy in Node-Negative T1a Versus T1b and T1c Triple Negative Breast Cancer
Authors: Fasano Genevieve A , Bayard Solange , Chen Yalei , Varella Leticia , Cigler Tessa , Simmons Rache , Swistel Alexander , Marti Jennifer , Moore Anne , Andreopoulou Eleni , Ng John , Brandmaier Andrew , Formenti Silvia , Ali Haythem , Davis Melissa , Newman Lisa 
Published: June 2021

Abstract
Purpose: National Comprehensive Cancer Network guidelines recommend delivery of adjuvant chemotherapy in node-negative triple negative breast cancer (TNBC) if the tumor is > 1 cm and consideration of adjuvant chemotherapy for T1b but not T1a disease. These recommendations are based upon sparse data regarding the role of adjuvant chemotherapy in T1a and T1b node-negative TNBC. Our objective was to clarify the benefits of chemotherapy for patients with T1N0 TNBC, stratified by tumor size.Methods: We performed a retrospective analysis of survival outcomes in an IRB-approved prospectively-maintained database of TNBC patients treated at two academic institutions in the United States from 1999-2018. Primary tumor size, histology, and nodal status were based upon definitive surgical pathology. Mean follow-up was 5.3 years.Results: 756 TNBC cases were analyzed; 258 T1N0 TNBC patients were identified. Adjuvant chemotherapy was delivered to 30.5% of T1a, 64.7% T1b, and 83.9% T1c (p < 0.0001). Factors associated with delivery of adjuvant chemotherapy were age, histology, high-grade disease, and postoperative adjuvant radiation therapy. At a mean follow-up of 5.3 years, increase in overall survival was associated with use of chemotherapy in patients with T1c disease (93.2% v. 75.2% p = 0.008) but not in those with T1a (100% v. 100% p = 0.3778) or T1b (100% v. 95.8% p = 0.2362) disease.Conclusion: Our data support current guidelines indicating benefit from adjuvant chemotherapy in node-negative TNBC associated with T1c tumors but excellent outcomes were observed in cases of T1a and T1b disease, regardless of whether adjuvant chemotherapy was delivered.
Post-Synthetic Modification of UiO66 and its Application in Catalytic Reactions
Authors: Qin Mingshan , Gao Juan , Wei Dongwei , Li Liuan , Li Cun , Yang Linyan 
Published: June 2021

Abstract
Because of their unique surface area and adjustable pore size, Metal-Organic Frameworks(MOFs) have been widely used in lots of research fields, such as catalysis, energy storage, sensing, separation. In this paper, as for the Knoevenagel reaction, UiO66 and other UiO series MOFs were synthesized and modified. UiO66 nanoparticles were prepared by one-pot method. 2-aminopyridine, 3-aminopyridine and 4-aminopyridine were used to prepare UiO66-2Py, UiO66-3Py and UiO66-4Py nanoparticles. UiO66-2Py, UiO66-3Py and UiO66-4Py nanoparticles were modified by activated arginine, lysine and glycine to synthesize UiO66-2Py-Arg, UiO66-3Py-Lys and UiO66-4Py-Gly. Finally, the obtained samples were used for the Knoevenagel catalytic condensation reactions of benzaldehyde and ethyl cyanoacetate. In this process, the prepared samples and their intermediates were characterized by infrared spectroscopy (IR) and X-ray diffraction(XRD), which showed that the modification of UiO66 was successful. UiO66-3Py-Lys and UiO66-4Py-Gly showed high catalytic activity in the supernatant determined by fluorescence spectrophotometer, and UiO66-4Py-Gly showed the best catalytic effects at the volume of 0.4mL benzaldehyde.