bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIL Testbed and Motion Control Strategy for the Hybrid Hydraulic-Electric Architecture (HHEA)
Authors: Chatterjee Arpan , Li Perry Y. 
Published: December 2021

Abstract
The Hybrid Hydraulic-Electric Architecture (HHEA) was proposed in recent years to increase system efficiency of high power mobile machines and to reap the benefits of electrification without the need for large electric machines. It uses a set of common pressure rails to provide the majority of power hydraulically and small electric motors to modulate that power for precise control. This paper presents the development of a Hardware-in-the-loop (HIL) test-bed for testing motion control strategies for the HHEA. Precise motion control is important for off-road vehicles whose utility requires the machine being dexterous and performing tasks exactly as commanded. Motion control for the HHEA is challenging due to its intrinsic use of discrete pressure rail switches to minimize system efficiency or to keep the system within the torque capabilities of the electric motor. The motion control strategy utilizes two different controllers: a nominal passivity based back-stepping controller used in between pressure rail switches and a transition controller used to handle the event of a pressure rail switch. In this paper, the performance of the nominal control under various nominal and rail switching scenarios is experimentally evaluated on the HIL testbed.
Simulated and Experimental Analysis of a Log Crane With Conventional and Direct Driven Hydraulics
Authors: Shevchuk Dmitrii , Malysheva Iuliia , Alizadeh Marjan , Handroos Heikki 
Published: December 2021

Abstract
The present paper compares the efficiency and dynamic behavior of a log crane while using two alternative transmissions. Firstly, the conventional mobile hydraulic valves with a load-sensing pump is used, and secondly, a novel electric-hydraulic energy converter and a direct driven hydraulic actuator is used. By applying lumped parameter models and the theory of centralized pressure, the hydraulic system models are constructed in MATLAB & Simulink environment. MathWorks Simscape Multibody is used in modeling of the multi-body system of the crane. The results of the simulation models are compared with those measured in the laboratory. Based on the verification results, such modes of operation in which the agreement between simulated results is the closest are selected for further investigation. The effectiveness of the system equipped with an electro-hydraulic converter is compared with that of the conventional system with a load sensing pump. Detailed models for components are given in the paper, and the results are discussed based on what obtained through simulation and experiments. The electric-hydraulic converter used in direct driven circuit is a novel prototype developed at LUT University. It has good power stiffness, and it provides good torque properties in a wide RPM area. The prototype is used in operating the lift or tilt cylinder, which is altered by using fast switching valves. The actual test circuit does not have electric storage. The ability of the converter to recover potential energy from the lifting system inertia is approximated in the efficiency comparisons.
Towards a Standard Taxonomy for Levels of Automation in Heavy-Duty Mobile Machinery
Authors: Machado Tyrone , Ahonen Andrei , Ghabcheloo Reza 
Published: December 2021

Abstract
Automated and autonomous systems change the nature of human interactions and their respective role within the systems. To characterize such changes, several domain specific levels of automation (LOA) taxonomies have been proposed over the years. The SAE J3016 levels for driving automation have been adopted as the de-facto standard in the automotive industry and the broader society. However, the heavy-duty mobile machinery (HDMM) industry does not have a commonly accepted LOA taxonomy, thereby relying on organizational specific LOA taxonomies adapted from SAE J3016. Moreover, HDMM handle and transport external materials in addition to driving tasks. Thus, SAE J3016 inadequately captures the manipulation operations of HDMM. This paper proposes a new LOA taxonomy for HDMM, to accommodate both, the manipulation and driving operations of HDMM. Building on the SAE J3016 taxonomy, the LOA in this paper is proposed as a two-dimensional 6 × 6 matrix, with machine manipulation operations on one dimension, and driving operations on the other. Thus, the LOA matrix could be generalized for HDMM in different application areas. The proposed LOA matrix could also serve as a guide and starting point for future standardized and collaborative discourse in HDMM research, development, and subsequent deployments.
Validation of the Circular Tandem Walk Test and Optimal Cutoff Score to Determine the Risk of Falls in Active Community-Dwelling Older Adults
Authors: Poncumhak Puttipong , Srithawong Arunrat , Duangsanjun Winut 
Published: December 2021

This study was to develop and validate the circular tandem walk test (CTWT) by deriving an optimal cutoff score to indicate the fall risk in 89 active community-dwelling older individuals. The participants aged 65 years and older were assessed for their demographic data, fear of fall variables, and history of falls in the past 6 months. Subsequently, participants were randomized for the sequence of tests between the tandem walk test and the CTWT. The outcomes of CTWT showed the highest significant correlation with all the fall variables (ranging from .631 to .827, p < .001). Moreover, the time to perform the CTWT ≥ 14.6 s and ≥ two error scores had excellent and acceptable diagnostic accuracy to determine the risk of falls in the older individuals, respectively. The CTWT can be used as alternative screening tests for assessing the fall risk in active older adults in community settings.
Increasing oxygen prescribing during the COVID-19 pandemic
Authors: Sahota Ramandeep , Kamieniarz Lukasz 
Published: December 2021

Valid oxygen prescriptions for hospital inpatients have been a long-standing problem and have been described extensively inBMJ Open Qualitywith numerous quality improvement projects (QIPs) with the aim of improving compliance with oxygen prescribing.The British Thoracic Society recommends that all inpatients should have oxygen target saturation set on admission: this is motivated by risks of both undertreatment and overtreatment with oxygen. The discrepancy between the recommendation and the reality produced a number of interventions studied in QIPs over the past years, all aiming at bringing the local ward teams closer to the target. This has become even more important during the COVID-19 pandemic, where non-standard oxygen saturation targets and oxygen scarcity led hospital systems to rethink their internal guidelines on the subject.We propose three novel interventions to improve compliance: a remote, personally directed email communication to a ward pharmacist, a similar communication to ward nurses, and a remote, personally directed WhatsApp communication to junior ward doctors. We undertake a QIP which compares novel interventions developed in-house with the most successful interventions from oxygen prescribing initiatives that have previously been published byBMJ Open Quality. The main outcome measure was the proportion of patients with valid oxygen prescription on a ward.The series of novel interventions in three plan, do study, act cycles led to improvement in the outcome measure from 0% at baseline to 70% at the end of the QIP. The successful interventions from previous QIPs were ran in parallel on a similar ward and achieved improvement from 17.9% at baseline to 55.6% at the end of the QIP.This QIP demonstrates adapted interventions performed in context of social distancing aimed at members of multidisciplinary team which achieve superiority in increasing proportion of patients with a valid oxygen prescription, when compared with previously described methods fromBMJ Open Quality.
Predicting oncotype DX recurrence scores using locally available immunohistochemical markers: experience in a district general hospital
Authors: Humphris Katherine , Stephenson John , Kumaraswamy Vidya 
Published: December 2021

AimsOncotype DX testing is a reliable widely used gene assay to determine whether chemotherapy is of additional value in oestrogen receptor (ER) positive Human Epidermal Growth Factor receptor 2 (HER2) negative, node negative breast cancer, but the high cost of the test can be a barrier for optimal therapy guidance for a substantial proportion of eligible patients around the world. We aimed to determine whether the commonly available immunohistochemical markers Ki67 and progesterone receptor (PR) can predict Oncotype DX Recurrence Score (RS) scores in a district general hospital setting.MethodsThe Oncotype DX RS scores from 58 tumours were regressed against corrected Ki67 values in a simple regression model, and against ER-derived and PR-derived indices and corrected Ki67 values in a multiple model. Model portability was assessed using leave-one-out cross-validation (LOOCV).ResultsAll terms in both regression models were significantly associated with RS scores at the 5% significance level (p<0.001 for all parameters). The multiple model was a better fit to the data (adjusted R2=0.784), and performed better under LOOCV (root mean square error=7.26), suggesting good predictive capability and model portability.ConclusionsLocally available, cheaper alternatives to multigene assays to determine therapy in ER positive HER2 negative patients is of benefit both from patient management and financial perspectives. A model has been derived with high capability to predict RS scores accurately from linear combinations of predictive biomarkers in a district general hospital setting, which should show good properties when applied to other samples.
Functional Analysis Identifies DamagingCHEK2Missense Variants Associated with Increased Cancer Risk
Authors: Boonen Rick A.C.M. , Wiegant Wouter W. , Celosse Nandi , Vroling Bas , Heijl Stephan , Kote-Jarai Zsofia , Mijuskovic Martina , Cristea Simona , Solleveld-Westerink Nienke , van Wezel Tom , Beerenwinkel Niko , Eeles Rosalind , Devilee Peter , Vreeswijk Maaike P.G. , Marra Giancarlo , van Attikum Haico 
Published: December 2021

AbstractHeterozygous carriers of germline loss-of-function variants in the tumor suppressor gene checkpoint kinase 2 (CHEK2) are at an increased risk for developing breast and other cancers. While truncating variants in CHEK2 are known to be pathogenic, the interpretation of missense variants of uncertain significance (VUS) is challenging. Consequently, many VUS remain unclassified both functionally and clinically. Here we describe a mouse embryonic stem (mES) cell–based system to quantitatively determine the functional impact of 50 missense VUS in human CHEK2. By assessing the activity of human CHK2 to phosphorylate one of its main targets, Kap1, in Chek2 knockout mES cells, 31 missense VUS in CHEK2 were found to impair protein function to a similar extent as truncating variants, while 9 CHEK2 missense VUS resulted in intermediate functional defects. Mechanistically, most VUS impaired CHK2 kinase function by causing protein instability or by impairing activation through (auto)phosphorylation. Quantitative results showed that the degree of CHK2 kinase dysfunction correlates with an increased risk for breast cancer. Both damaging CHEK2 variants as a group [OR 2.23; 95% confidence interval (CI), 1.62–3.07; P &lt; 0.0001] and intermediate variants (OR 1.63; 95% CI, 1.21–2.20; P = 0.0014) were associated with an increased breast cancer risk, while functional variants did not show this association (OR 1.13; 95% CI, 0.87–1.46; P = 0.378). Finally, a damaging VUS in CHEK2, c.486A&gt;G/p.D162G, was also identified, which cosegregated with familial prostate cancer. Altogether, these functional assays efficiently and reliably identified VUS in CHEK2 that associate with cancer.Significance:Quantitative assessment of the functional consequences of CHEK2 variants of uncertain significance identifies damaging variants associated with increased cancer risk, which may aid in the clinical management of patients and carriers.
A Pan-Cancer Immunogenomic Atlas for Immune Checkpoint Blockade Immunotherapy
Authors: Yang Jing , Zhao Shilin , Wang Jing , Sheng Quanhu , Liu Qi , Shyr Yu 
Published: December 2021

Abstract

The ability to identify robust genomic signatures that predict response to immune checkpoint blockade is restricted by limited sample sizes and ungeneralizable performance across cohorts. To address these challenges, we established Cancer-Immu (http://bioinfo.vanderbilt.edu/database/Cancer-Immu/), a comprehensive platform that integrates large-scale multidimensional omics data, including genetic, bulk, and single-cell transcriptomic, proteomic, and dynamic genomic profiles, with clinical phenotypes to explore consistent and rare immunogenomic connections. Currently Cancer-Immu has incorporated data for 3,652 samples for 16 cancer types. It provides easy access to immunogenomic data and empowers researchers to translate omics datasets into biological insights and clinical applications.

Significance:
Cancer-Immu is a comprehensive functional portal for unraveling immune-genomic connections to improve immune checkpoint blockade–based cancer immunotherapy.
The Inequitable Effects of Teacher Layoffs: What We Know and Can Do
Authors: Kraft Matthew A. , Bleiberg Joshua F. 
Published: December 2021

Abstract
Economic downturns can cause major funding shortfalls for U.S. public schools, often forcing districts to make difficult budget cuts, including teacher layoffs. In this brief, we synthesize the empirical literature on the widespread teacher layoffs caused by the Great Recession. Studies find that teacher layoffs harmed student achievement and were inequitably distributed across schools, teachers, and students. Research suggests that specific elements of the layoff process can exacerbate these negative effects. Seniority-based policies disproportionately concentrate layoffs among teachers of color, who are more likely to be early career teachers. These “last-in first-out” policies also disproportionately affect disadvantaged students because these students are more likely to be taught by early career teachers. The common practice of widely distributing pink slips warning about a potential job loss also appears to increase teacher churn and negatively impact teacher performance. Drawing on this evidence, we outline a set of policy recommendations to minimize the need for teacher layoffs during economic downturns and ensure that the burden of any unavoidable job cuts does not continue to be borne by students of color and students from low-income backgrounds.
Dynastic Potential Crossover Operator
Authors: Chicano Francisco , Ochoa Gabriela , Whitley L. Darrell , Tinós Renato 
Published: December 2021

Abstract
An optimal recombination operator for two-parent solutions provides the best solution among those that take the value for each variable from one of the parents (gene transmission property). If the solutions are bit strings, the offspring of an optimal recombination operator is optimal in the smallest hyperplane containing the two parent solutions. Exploring this hyperplane is computationally costly, in general, requiring exponential time in the worst case. However, when the variable interaction graph of the objective function is sparse, exploration can be done in polynomial time. In this article, we present a recombination operator, called Dynastic Potential Crossover (DPX), that runs in polynomial time and behaves like an optimal recombination operator for low-epistasis combinatorial problems. We compare this operator, both theoretically and experimentally, with traditional crossover operators, like uniform crossover and network crossover, and with two recently defined efficient recombination operators: partition crossover and articulation points partition crossover. The empirical comparison uses NKQ Landscapes and MAX-SAT instances. DPX outperforms the other crossover operators in terms of quality of the offspring and provides better results included in a trajectory and a population-based metaheuristic, but it requires more time and memory to compute the offspring.
Global Warming Pattern Formation: The Role of Ocean Heat Uptake
Authors: Hu Shineng , Xie Shang-Ping , Kang Sarah M. 
Published: December 2021

Abstract
This study investigates the formation mechanism of the ocean surface warming pattern in response to a doubling CO2 with a focus on the role of ocean heat uptake (or ocean surface heat flux change, ΔQnet). We demonstrate that the transient patterns of surface warming and rainfall change simulated by the dynamic ocean–atmosphere coupled model (DOM) can be reproduced by the equilibrium solutions of the slab ocean–atmosphere coupled model (SOM) simulations when forced with the DOM ΔQnet distribution. The SOM is then used as a diagnostic inverse modeling tool to decompose the CO2-induced thermodynamic warming effect and the ΔQnet (ocean heat uptake)–induced cooling effect. As ΔQnet is largely positive (i.e., downward into the ocean) in the subpolar oceans and weakly negative at the equator, its cooling effect is strongly polar amplified and opposes the CO2 warming, reducing the net warming response especially over Antarctica. For the same reason, the ΔQnet-induced cooling effect contributes significantly to the equatorially enhanced warming in all three ocean basins, while the CO2 warming effect plays a role in the equatorial warming of the eastern Pacific. The spatially varying component of ΔQnet, although globally averaged to zero, can effectively rectify and lead to decreased global mean surface temperature of a comparable magnitude as the global mean ΔQnet effect under transient climate change. Our study highlights the importance of air–sea interaction in the surface warming pattern formation and the key role of ocean heat uptake pattern.
Development of 4to24, a Transition Application for Parents of Students With Visual Impairments
Authors: Antonelli Karla , Cmar Jennifer L. , Steverson Anne 
Published: December 2021

Introduction This article focuses on the development of 4to24, an informational app for parents of students with visual impairments, with emphasis on obtaining stakeholder input, developing content, and establishing content validity. The app provides information, resources, and activities to help students, ages 4–24 years, prepare for independence and employment as an adult. Method App design and content development involved multiple phases of iterative design and writing. Stakeholder input was obtained via an advisory board and user focus groups with parents and students. Experts reviewed and validated content with ratings and recommendations on accuracy, age-appropriateness, and relevance. Results Advisory board members identified important domains to address in 4to24 including social skills, technology, travel skills, health and fitness, independent living, career education, and self-determination. They recommended focusing on elevating parents’ expectations and confidence in supporting and teaching their children. Focus group participants recommended accessibility, ease of use, and relevant information to make the app appealing to users. The content validation process supported the content’s relevance, accuracy, and age-appropriateness and resulted in a final count of 410 informational modules. Discussion Parent involvement and expectations are critical to students’ preparation for future employment. 4to24 provides support for parents to collaborate with service providers and reinforce concepts and skills outside of school. Development of the app technology and its large volume of content required a full 5-year process. Implications for practitioners Lessons learned from this project can inform future resource development projects, including recommendations to start small and define goals early in the process. The 4to24 app is a new resource for parents of students with visual impairments that can supplement services provided by professionals.
Accommodations Knowledge and Practice for Students With Visual Impairments
Authors: Nannemann Allison C. 
Published: December 2021

Introduction Classroom accommodations are a primary means of supporting the appropriate education for students with disabilities. Student involvement in the accommodation process is valuable. Therefore, we need to teach students to be knowledgeable and strategic regarding their accommodations. Methods Four high school students with visual impairments were taught the Student Self-Accommodation Strategy (SSA). A comparative case studies approach within a sequential explanatory design was used to investigate their accommodations knowledge and practices. Results Participants improved or maintained accommodations knowledge. Their most-used types of accommodations were access accommodations and accommodations for content support. Three of the participants increased advocacy after strategy instruction. The participants’ accommodation practices were influenced by emotional-behavioral regulation, independence, and teacher involvement. Discussion Findings from this study relate to existing literature on accommodations support, teacher involvement in the accommodations process, instruction in accommodations advocacy, and the relationship between accommodations and emotional-behavioral dysregulation. Implications Findings emphasize the need to be explicit about the accommodations available to students with visual impairments and the need for strategy instruction in the SSA to address emotional-behavioral dysregulation.
Mass hysteria attack rates in children and adolescents: a meta-analysis
Authors: Zhao Gang , Cheng Qinglin , Dong Xianming , Xie Li 
Published: December 2021

Objectives There are few systematic assessments of mass hysteria (MH) attack rates (ARs) in adolescents and children. The study aim was to assess the ARs of MH in this population. Methods We used a meta-analysis to systematically review studies and assess ARs. Results The reviewed studies included 32,887 participants, of which 2968 were children and adolescents with a history of MH. Twenty-eight studies were included, of which 22 (78.6%) had high to moderate methodological quality. The pooled AR of MH was 9.8% (95% confidence interval [CI] 6.3, 14.0). Of MH studies between 2010 and 2020, 78.6% were conducted between 2010 and 2014. ARs were higher between 2010 and 2014 (10.3%) than between 2015 and 2020 (8.1%). Regarding population characteristics, the AR in girls was 2.43 (95% CI 1.70, 3.46) times higher than in boys. Most studies were on primary school students (46.4%), who showed the highest AR (15.4%). Of six trigger factors, water pollution showed the highest AR (16.3%). ARs were higher in rural areas (11.1%) than in urban areas (5.6%). Conclusions MH in children and adolescents seems prevalent and shows some epidemiological characteristics. These findings may assist governments to control and prevent MH epidemics among children and adolescents.