bluuebunny/crossref_metadata_2025_split huggingface dataset:
oxicological effects of artemether-nevirapine coadministration on serum biochemistry and some organs of Wistar rats
Authors: Anafi Sherifat B. , Kwanashie Helen O. , Anuka Joseph A. , Bissalla Mohammed 
Published: April 2021

This study investigated toxicological effects of 5 and/or 10 mg/kg artemether (ART5 or ART10) and nevirapine (NVP) co-administration on serum biochemistry and some organs of Wistar rats. Drugs were administered intraperitoneally to 6 groups (n=6) for 21 days. On day 22, rats were sacrificed, sera obtained to determine electrolyte and antioxidant levels. Liver, kidney, lung and spleen were harvested and weighed for histological studies. Data analysed using oneway ANOVA, Dunnett’s post-hoc test and were considered significant at p≤0.05. There was no difference in superoxide, catalase, Na+ , K+ , Ca2+ and HCO3- levels in the treated groups. Cl- decreased (p≤0.05) in NVP + T80 and NVP + ART10 administered groups. MDA increased (p≤0.05) in NVP + ART10 group while GPx decreased. No pathological changes were observed in the liver of all treated groups but relative weight increased (p≤0.05) in NVPART10 treated group. The kidney of NVP-ART5 and NVP-ART10 treated groups did not differ in relative weight but showed some renal necrosis. The spleen and lung of ART10 treated group showed some pathological changes. The changes in relative liver weight, kidney tissue, Cl-, MDA and GPx levels of ART-NVP administered rats suggest the need for precautionary measures during drug treatment combination.
Keywords: Artemether; Nevirapine; Toxicology; Liver; Kidney; Spleen; Lung, Biochemical parameters
Peer reviewed abstract submitted to the College of Health Sciences, Osun State University Annual Scientific Conference, June 15-19, 2020
Authors: Akinleye C.A. , Onabule A. , Oyekale A.O. , Akindele M.O. , Babalola O.J. , Olarewaju S.O. 
Published: April 2021

Introduction: MDR-TB poses a significant challenge to global management of TB. Laboratories in many countries among which include Nigeria are unable to evaluate drug resistance, and clinical predictors of MDR-TB might help target suspected patients.Method: The study was a cross sectional study design. Multistage sampling technique was employed in the selection of 403 tuberculosis patients. Data were analyzed using SPSS version 25. Level of significance was set at P<0.05.Results: Fifty three 53 (13.2%) of the total respondent had MDR-TB compare to national prevalence of 8% which is steeper among males 36(67.9%) (p>0.05). Education and Occupation shows a significant association with MDR-TB, (÷2=24.640, p = 0.007) and (÷2=14.416, p=0.006) respectively, smoking (r=0.074, p<0.05) and alcohol consumption (r=0.083, p>0.05) show no significant association with occurrence MDR-TB.Conclusion: Previous TB treatment and Adherence with treatment regimen were found to be the major risk factor for MDR-TB. Targeted educational intervention for patients and their contacts may minimize the non-adherence with prescribed TB treatment and lessen MDR-TB magnitude.
Key words: TB Patients, MDR-TB, tuberculosis, risk factors.
Morphoanatomy of striated myofibers in streptozotocin-induced diabetic wistar rats: assuaging effect of combined doses of Vernonia amygdalina and Azadirachta indica
Authors: Yama O.E. , Adeteye O.V. , Kusemiju T.O. , Avidime O.M. , Danboyi T. , Odetola A.A. , Mohammed K.A. 
Published: April 2021

Objective: This study aimed to evaluate the effects of Azadirachta indica and Vernonia amygdalina extracts on the morphoanatomy of striated myofibrils in diabetic rat models.
Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water only, B (herbal) received A. indica (500 mg/kg/day) and V. amygdalina (400 mg/kg/day) simultaneously, C were diabetic rats, D were diabetic rats treated with herbal extracts combined and E, diabetic rats treated with metformin. Diabetes was induced with streptozotocin (70 mg/kg). Muscles glutathione peroxidase (GPx) and blood glucose levels were determined. The rats were sacrificed at the end of 60days treatment. The quadriceps femoris muscle harvested for histology.
Results: Diabetic herbal treated rats became euglycemic by the end of 8 weeks. GPx activity was significantly (p<0.05) elevated compared to control. The histology of skeletal muscle fibers of the diabetic rats treated with herbal formulation and metformin showed minimal level of damage.Conclusions: The findings in this study showed that the herbal formulation could be used in treatment of diabetes and in ameliorating the associated muscular cytoarchitectural alterations.
Keywords: diabetic, extract, glutathione, peroxidase
Advantage of the regenerative potentials of the periosteum especially in children, Oghara experience: A case series
Authors: Enemudo R.E.T. , Odatuwa-Omagbemi D.O. , Edomwonyi E.O. , Obumse A.T. , Akpojevwe E.O. 
Published: April 2021

The periosteum is a composite tissue comprising an outer protective fibrovascular layer and an inner cambium regenerative pluripotent layer. The regenerative function of periosteum has been put to clinical use by dental surgeons to manage alveolar ridge reduction and by tissue engineers to produce autologous micrograft and collagen used to manage complex wounds and scars. The essence of this study is to add to the body of knowledge on clinical use of periosteum to treat bone defects from the orthopaedic perspective. We highlight a case series to demonstrate the use of periosteum in managing bone defects caused by benign bone tumour, chronic osteomyelitis, tibial hemimelia and traumatic bone loss of the distal tibia in Delta State University Teaching Hospital, Oghara. Treatment of bone defects by this means is cost effective and the outcome is very satisfactory.
Key words: Periosteum, mesenchymal stem cells, bone defects, distraction histiogenesis.
Nigeria’s development process, methodology and milestones planned for VISION 20:2020 - 13 years after
Authors: Adekomi D.A. , Alebiosu C.O. 
Published: April 2021

Regional and international economic integration
Regional economic integration has helped many countries of the world to concentrate on issues that are essential to their development as well as encourage local, national, and international trade between countries and neighbors. In the past years, there has been increase in trading blocs with numerous agreements in place and more in the pipeline(s). These agreements provide more opportunities for countries to interact and trade with one another without barriers to investment and trade. This manuscript discusses regional and international economic integrations in line with VISION-20-20 and the Nigeria economy.
Keywords: Trade, investment, money, economic goals, Africa
Emerging Viral Disease and Orthopaedic Surgeons: COVID-19 PANDEMIC
Authors: Edomwonyi E.O. , Anyaehie U.E. , Onuminya J.E. 
Published: April 2021

Background: COVID-19 is caused by novel Coronavirus Severe Acute Respiratory Syndrome-Corona Virus (SARS-Cov-2). It is purported to have originated from bat in Wuhan province of China in December, 2019. The epidemic spreads rapidly, reaching a pandemic proportion in January, 2020. The economic implications of the pandemic and burden on health care are enormous. We, therefore, review the impact of this disease to orthopaedic practice.Methods: A comprehensive review of the literature, using suitable keywords, such as COVID -19, viral disease, orthopaedic surgery, on the search engines of PUBMED, Google Scholar and SCOPUS in June 2020.Results: The current treatment of COVID-19 is largely supportive. Lockdown, social distancing, are among many social preventive measures that had been adopted in an attempt to halt the spread of this disease. These Social adjustments, are achieving remarkable results. Intensive monitoring is key. Profound modifications had been made in all spheres of orthopaedic practice, suspending elective surgical cases and modifying the handling of inpatients and outpatients.Conclusions: Globally, orthopaedic practice has been altered in elaborate terms, to accommodate peculiarities of this emerging viral disease, COVID-19. Whilst not neglecting the needs of our patients who depend on us for due care, strict precautions have been adopted to protect patients and health care workers or halt the spread of the disease.
Key words: COVID-19, pandemic, orthopaedic surgeon
Community-acquired lower respiratory tract infections in an adult population with HIV infection in a Nigerian tertiary hospital
Authors: Odeyemi A.O. , Odeyemi A.O. , Awopeju O.F. , Adewole O.O. , Tanimowo M.O. , Tanimowo M.O. , Erhabor G.E. 
Published: April 2021

Objective: Lower respiratory tract infections (LRTI) are 25-fold more common in people with HIV than in the general population. This study aimed to determine the prevalence of community-acquired LRTI and its associated factors in an adult population of people living with HIV (PLWH) in a Nigerian tertiary Hospital.Methodology: This was a prospective study done at the HIV clinic of Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital Osogbo, Nigeria. It involved 130 randomly selected adult participants with a confirmed HIV-positive serology. The participants were followed up for a period of one year while looking out for symptoms and signs suggestive of LRTI.Results: The participants had a mean age of 41.9±10.02 years and a male to female ratio of 0.4:1. Seventeen (13.9%) of the participants developed LRTI during the study period and this was significantly associated with CD4 count and cigarette smoking history.Conclusion: LRTI is common among PLWH in Osogbo, and it occurs more commonly in those with low CD4 Tcell count and those with a history of cigarette smoking.
Keywords: Lower respiratory tract infection, HIV, pneumonia.
Avaliação in vitro do potencial antimicrobiano de Morinda citrofolia -Noni e do óleo de Melaleuca em Candida albicans
Authors: Silva Gabrielle Cristina Figueiredo da , Pereira Leonardo de Paula , Teixeira Caio Wilker , Marteleto Natielle Cerceau , Casteluber Marisa Cristina da Fonseca 
Published: April 2021

A Candida albicans é uma levedura considerada oportunista responsável por causar infecções quando à uma baixa no sistema imunológico do indivíduo. Com o aumento do número de microrganismos multirresistentes a fármacos convencionais, é importante o estudo da composição destas plantas para descoberta de tratamentos naturais alternativos. Portanto o objetivo do trabalho foi avaliar o potencial antimicrobiano do extrato de Morinda citrofolia e o óleo de Melaleuca sobre Candida albicans. A preparação do extrato de M. citrtofolia foi obtida através do fruto maduro descascado, despolpados e sem sementes, posteriormente foi filtrado em uma peneira de 400 micras e centrifugado a 600G durante seis minutos, após a centrifugação foram retirados os sedimentos filamentosos e filtrado em em um copo coletor com uma peneira de 10 micras. Já o óleo essencial de melaleuca foi diluído 10% em óleo vegetal. Para o cultivo de Candida albicans foi inoculado em ágar sabouraud dextrosado utilizando a tecnica de espalhamento e mantida em estufa por um período de 7 a 14 dias em temperatura de 28-30°C. Em todos os testes feitos o óleo essencial de melaleuca, foi o que apresentou o maior halo de inibição, seguido do Fluconazol (usado como controle positivo) que apresentou halos menores ou iguais ao do óleo de melaleuca quando comparado ao controle negativo e ao Noni (p≤ 0.05) que apresentou um índice inibitório considerável. O número de triplicatas foi mais do que o suficiente para comprovar a hipótese experimental da eficácia do óleo de melaleuca e do extrato de Noni como inibidores do crescimento de Candida albicans.
Análise histopatológica da cérvice uterina de mulheres em cárcere de Mato Grosso
Authors: Caldeira Aline da Silva , Terças-Trettel Ana Cláudia Pereira , Nascimento Vagner Ferreira do , Hattori Thalise Yuri , Menezes Andreza Lucia 
Published: April 2021

A neoplasia de colo de útero impacta na morbimortalidade de mulheres no mundo, quando diagnosticado precocemente as chances de cura são significantes, assim a utilização do teste de Papanicolau é uma ferramenta primordial. Objetivou-se analisar achados histopatológicos da cérvice uterina de reeducandas de Mato Grosso. Trata-se de estudo de coorte aberta, em que a coleta de dados foi realizada sequencialmente em 2017 e 2018, por meio de entrevista semiestruturada e coleta de amostra da cérvice uterina pela técnica de Papanicolau. A amostra do estudo foi composta predominantemente de mulheres jovens, de cor parda, renda mensal de um a dois salários mínimos, detidas por tráfico, e que já haviam realizado exame preventivo em algum momento de sua vida. As alterações benignas ou reparativas foram observadas em ambos os anos da análise. Os achados deste estudo mostraram resultados satisfatórios com relação a análise histopatológica das reeducandas, indicando a presença de saúde.
PENINGKATAN HASIL BELAJAR PADA MATERI MEMBANDINGKAN BANYAK BENDA MELALUI MEDOT UNTUK SISWA KELAS I SDN NGAGEL I/ 394 SURABAYA
Authors: Handriyani Ida 
Published: April 2021

Penelitian ini dilatarbelakangi banyaknya siswa kelas I-a SDN Ngangel 1/ 394 belum tuntas belajar Matematika pada materi pelajaran membandingkan banyak benda. Penyebab kelemahan siswa dalam membandingkan banyak benda adalah : 1) siswa kurang menguasai materi perbandingan banyak benda, 2) siswa tidak teliti membandingkan banyak benda, 3) siswa kurang berkonsentrasi saat guru menerangkan materi membandingkan banyak benda. Hal ini disebabkan oleh pola pengajaran selama ini bersifat ceramah dan tanpa menggunakan media pembelajaran konkret sehingga siswa mudah bosan dan jenuh serta kurang terlibat aktif ketika pembelajaran. Tujuan penelitian untuk mengetahui keaktifan dan hasil belajar siswa kelas I SDN Ngagel I/ 394 dengan penerapan medot (media sedotan). Hasil pengolahan data yang telah dilakukan setelah penerapan media sedotan pada pembelajaran Matematika diperoleh hasil Aktivitas guru siklus I sebesar 73,75%, siklus II 85%. Sedangkan aktivitas siswa siklus I 61,90% dan di siklus II 70,78%. Tes hasil belajar siswa juga meningkat, persentase ketuntasan belajar Siklus I 67,86% dan meningkat di siklus II 82,14%. Skor rata-rata siswa siklus I sebesar 76,86, meningkat di siklus II menjadi 81,10. Hasil penelitian di atas dapat disimpulkan penggunaan media sedotan pada pembelajaran matematika materi membandingkan banyak benda mampu meningkatkan keaktifan dan hasil belajar siswa.
ROH KUDUS DALAM TEOLOGI PERJANJIAN BARU I:
Authors: Wibowo Moses 
Published: April 2021

Teologi Perjanjian baru adalah bidang yang luas. Namun demikian fokus dari teologi PB adalah Allah dan karya-Nya dalam rangka misi penyelamatkan manusia berdosa dengan membentuk komunitas baru. Karya keselamtan ini datang dari Allah, dikerjakan oleh dan dalam Yesus Kristus dan direalisasikan bagi orang percaya oleh Roh kudus dan karya-Nya. Artikel ini akan mengulas secara khusus tentang Roh kudus dan karya-Nya sebagai agen misi Allah kedua secara berkala dan berkesinambungan. Dalam mengulas, akan menggunakan pendekatan historis-teologis dengan menjadikan Alkitab dan khususnya PB sebagai dokumen kanonik yang Allah berikan kepada gereja sebagai sang pemelihara. Pengungkapan dan pengulasan pribadi Roh kudus dan karya-Nya sebagai agen misi Allah kedua dalam rangka menuntaskan misi penyelamatan akan dimulai dari dokumen Injil Sinoptik dan Kisah Para Rasul dengan menjadikan karya Marshall: New Testament Theology sebagai sebuah patron.
TINJAUAN TEOLOGIS-ETIS TENTANG BISNIS MEMBUNGAKAN UANG
Authors: Bambangan Malik 
Published: April 2021

Kebutuhan hidup manusia dalam segala aspek semakin hari semakin meningkat seiring dengan naiknya harga sembako yang semakin tinggi. Hal ini menuntut berbagai daya dan upaya yang dilakukan oleh manusia untuk memenuhi kebutuhan hidup tersebut agar tetap bertahan hidup. Namun karena himpitan ekonomi ini terlalu menekan hidup rakyat, maka banyak rakyat yang hidup miskin, melarat dan menderita. Banyaknya tuntutan hidup dalam kondisi ekonomi yang semakin carut-marut ini, memaksa pemerintah untuk segera turun tangan menyelesaikannya. Sebagai upaya pemerintah telah mengadakan KUD, UKM, KUR, BPR dan BKK. Program pemerintah dalam pengentasan kemiskinan seperti ini sedikit memberi solusi, namun sayangnya karena hal itu hanya berlaku bagi rakyat yang ekonominya menengah ke atas, untuk meningkatkan bisnis mereka. Sementara itu, untuk kelas ekonomi menengah ke bawah, semakin tertindas dalam kemiskinannya dan tidak diperhatikan. Hal ini seakan-akan menjadi pembiaran oleh pihak pemerintah yang membiarkan rakyat kecil, miskin hidup dalam kemelaratan. Sebagai dampak dari pembiaran ini maka muncullah kelompok yang ingin membantu sesamanya terbebas dari jerat kemiskinan itu. Kelompok ini memberikan pinjaman uang kepada siapa saja yang membutuhkan pinjaman disertai dengan bunganya. Kelompok ini sepertinya memberikan solusi yang cepat namun tidak tepat dalam memenuhi kebutuhan hidup. Karena pemberian pinjaman uang yang disertai dengan bunga serta waktu yang relatif singkat dalam pengembaliannya, hanya menguntungkan pihak pemberi pinjaman uang, sementara yang meminjam kembali terjebak dalam kubangan hutang bunga uang yang di pinjam untuk dibayar. Itulah sebabnya kelompok pelepas uang atau pemberi pinjaman uang ini disebut RENTENIR.
MANFAAT KOMPETENSI GURU TERHADAP PRESTASI BELAJAR
Authors: Sibarani Mortan 
Published: April 2021

Kompetensi yang seharusnya dimiliki seorang guru yakni kompetensi kepribadian, kompetensi pedagogik, kompetensi profesional dan kompetensi sosial maupun kompetensi kerohanian (spritual). Berkaitan dengan faktor guru yang begitu menentukan di dalam kegiatan belajar mengajar, dalam bagian ini dibahas manfaat Kompetensi Guru bagi Kemajuan Prestasi Belajar Murid. Hal ini berarti kemampuan atau kecakapan, berkaitan dengan pemilikan, pengetahuan atau kecakapan maupun ketrampilan sebagai guru.
The Medical Management of Arsha with Chirabilwadi Quatha and Kaseesadi Thaila Sthanika Abhyanga
Authors: Gandagi Nagesh , Patil Shubhangi 
Published: April 2021

ArshaÂ (Piles) is the one of the most common disease encountered in clinical and surgical practice.Â ArshaÂ incidence increases with advancing age, at least 50% of people over the age of 50 years have some degree of haemorrhoidal symptoms.Â In this study an attempt has been made to treat the â€œdiseaseâ€ withÂ Chirabilwadi quatha (Panartha)Â andÂ Kaseesadi thaila (Sthanika abhyanga).Â Total thirty patients were selected by simple randomized method and allocated into three groups called Group A, B, C. Each group had ten patients. Group A. treated withÂ Chirabilwadi quatha(Panartha),Â Group B. treated withÂ Kaseesadi thailaÂ and Group C. treated with combination ofÂ Chirabilwadi quathaÂ andÂ Kaseesadi thaila. Total study period was nighty days in that thirty days was treatment and sixty days was fallow-up. The effect of treatment was observed both in subjective symptoms and objective parameters. Non significant, Significant and highly significant results were observed in subjective parameters, objective parameters and overall in all three groups.
A Comparative Study of Shyamatrivruttadi Kalka and Bruhatiphala-Dwiharidra Kalka Yonipuran in Kaphaja Yonivyapad
Authors: D Pinge C , J Kulkarni C , K Danga S , Yogita Bende , Anita Bombarde , Anuradha Khandekar 
Published: April 2021

Introduction: A healthy woman is a promise of healthy family. The concept of healthy yoni has been asserted in various phase of womanâ€™s life from puberty to marriage to child birth and thereafter. Due to change in lifestyle, modern food habits of fast food, junk food she is unable to follow the rules of Dincharya, Rutucharya, Rajaswala, Rutumati and Sutikaparicharya which are explained by Aacharyas for womenâ€™s health. Thus she is prone to various yonirogas, one of which is Yonigat Shewta-Picchilsrava, Yonikandu, Yonigata Alpa vedana which are the features of Kaphaja yonivyapada and is neglected by women as minor symptoms. Aims and Objectives: 1.To evaluate the efficacy of Shyamatrivruttadi kalka in kaphajaÂ Yonivyapad & Bruhatiphala-Dwiharidra kalka in kaphajaÂ yonivyapad. Materials and Methods: The female patients within 18 to 45 years of age group complaining mainly of kaphaja yonivyapad were selected irrespective of occupation, religion and prakruti. Conclusion: Most of the patients in experimental group showed better relief in sign symptoms as compared to the control group, it is obvious from the all analysis of data that the drug in experimental group had definitely better role than control group to alleviate clinical features in Kaphaj yonivyapad.
A Case study on the management of Obsessive Compulsive Disorder (OCD) in Ayurveda
Authors: S Niranjan , Swayamprava Swapna 
Published: April 2021

Â Â Â Â Â Â Obsessive-compulsive disorder (OCD) is a type of anxiety disorder in which a person has unreasonable thoughts and fears (obsessions) that lead him to engage in repetitive behaviors (compulsions). A person affected with OCD may realize that his obsessions are not reasonable and may try to ignore or stop them, but he is driven to perform compulsive acts in an effort to ease his distress. OCD usually centers on themes which lead to ritualistic behaviour that ultimately affects the person's life.Â In this paper a case study of OCD with the symptoms of obsessions of contamination associated with mild depression and Parkinsonâ€™s disease is discussed which was successfully treated with some Ayurvedic formulations for about 2 months.Â
A preliminary phyto-pharmacognostical evaluation of Opuntia elatior Mill. (Nagaphani or Hathalo-thore) fruit
Authors: Patel Hemil , Prajapati Shashikant , Acharya Rabinarayan , CR Harisha , Shukla Vinay 
Published: April 2021

In Gujarat, Opuntia elatior Mill., a member of Cactaceae family known as Nagaphani or Hathlo-thore has been reported for its traditional uses as a medicinal plant. It is used as remedy in different disease conditions like anaemia, asthma etc. by tribal of Gujarat state. A detailed pharmacognostical character and pharmaceutical analysis of its fruit is not reported still yet. An attempt has been made to study the macroscopic, microscopic, physicochemical parameters and HPTLC profile of its fruit following standard procedures. Results show in Transverse section of unripe fruit, presence of outer exocarp layer with rosette crystals, followed by mesocarp and inner endocarp. Transverse section of ripen fruits, shows presence of same characters as fresh unripe fruit except the presence of betacyanins in its mesocarp layer. Powder microscopy of mature fruit shows diagnostic characters like multicellular tri chomes, rosette crystals of calcium oxalate, coloring matter and starch grains. The ash value of O. elatior fruit Â Â is 3.59 % w/w, pH - 5.27, total solid content - 10.83 %, viscosity - 5.11 and Specific gravity is 1.042. HPTLC study showed the presence of four and two spots in short and long UV respectively, among them, 0.04 and 0.97 are the common Rf value. These observed pharmacognostical, physicochemical parameters and HPTLC profile may be useful to establish the botanical standards for identification and standardization of O. elatior fruit