bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glissonean approach for hepatic inflow control in minimally invasive anatomic liver resection: A systematic review
Authors: Morimoto Mamoru , Tomassini Federico , Berardi Giammauro , Mori Yasuhisa , Shirata Chikara , Abu Hilal Mohammed , Asbun Horacio J. , Cherqui Daniel , Gotohda Naoto , Han Ho‐Seong , Kato Yutaro , Rotellar Fernando , Sugioka Atsushi , Yamamoto Masakazu , Wakabayashi Go ,   Study group of Precision Anatomy for Minimally Invasive Hepato‐Biliary‐Pancreatic surgery (PAM‐HBP surgery)
Published: February 2021

AbstractBackgroundThe Glissonean approach has been widely validated for both open and minimally invasive anatomic liver resection (MIALR). However, the possible advantages compared to the conventional hilar approach are still under debate. The aim of this systematic review was to evaluate the application of the Glissonean approach in MIALR.MethodsA systematic review of the literature was conducted on PubMed and Ichushi databases. Articles written in English or Japanese were included. From 2,390 English manuscripts evaluated by title and abstract, 43 were included. Additionally, 23 out of 463 Japanese manuscripts were selected. Duplicates were removed, including the most recent manuscript.ResultsThe Glissonean approach is reported for both major and minor MIALR. The 1st, 2nd and 3rd order divisions of both right and left portal pedicles can be reached following defined anatomical landmarks. Compared to the conventional hilar approach, the Glissonean approach is associated with shorter operative time, lower blood loss, and better peri‐operative outcomes.ConclusionsGlissonean approach is safe and feasible for MIALR with several reported advantages compared to the conventional hilar approach. Clear knowledge of Laennec's capsule anatomy is necessary and serves as a guide for the dissection. However, the best surgical approach to be performed depends on surgeon experience and patients’ characteristics. Standardization of the Glissonean approach for MIALR is important.
Estimating the contribution of key populations towards HIV transmission in South Africa
Authors: Stone Jack , Mukandavire Christinah , Boily Marie‐Claude , Fraser Hannah , Mishra Sharmistha , Schwartz Sheree , Rao Amrita , Looker Katharine J , Quaife Matthew , Terris‐Prestholt Fern , Marr Alexander , Lane Tim , Coetzee Jenny , Gray Glenda , Otwombe Kennedy , Milovanovic Minja , Hausler Harry , Young Katherine , Mcingana Mfezi , Ncedani Manezi , Puren Adrian , Hunt Gillian , Kose Zamakayise , Phaswana‐Mafuya Nancy , Baral Stefan , Vickerman Peter 
Published: February 2021

AbstractIntroductionIn generalized epidemic settings, there is insufficient understanding of how the unmet HIV prevention and treatment needs of key populations (KPs), such as female sex workers (FSWs) and men who have sex with men (MSM), contribute to HIV transmission. In such settings, it is typically assumed that HIV transmission is driven by the general population. We estimated the contribution of commercial sex, sex between men, and other heterosexual partnerships to HIV transmission in South Africa (SA).MethodsWe developed the “Key‐Pop Model”; a dynamic transmission model of HIV among FSWs, their clients, MSM, and the broader population in SA. The model was parameterized and calibrated using demographic, behavioural and epidemiological data from national household surveys and KP surveys. We estimated the contribution of commercial sex, sex between men and sex among heterosexual partnerships of different sub‐groups to HIV transmission over 2010 to 2019. We also estimated the efficiency (HIV infections averted per person‐year of intervention) and prevented fraction (% IA) over 10‐years from scaling‐up ART (to 81% coverage) in different sub‐populations from 2020.ResultsSex between FSWs and their paying clients, and between clients with their non‐paying partners contributed 6.9% (95% credibility interval 4.5% to 9.3%) and 41.9% (35.1% to 53.2%) of new HIV infections in SA over 2010 to 2019 respectively. Sex between low‐risk groups contributed 59.7% (47.6% to 68.5%), sex between men contributed 5.3% (2.3% to 14.1%) and sex between MSM and their female partners contributed 3.7% (1.6% to 9.8%). Going forward, the largest population‐level impact on HIV transmission can be achieved from scaling up ART to clients of FSWs (% IA = 18.2% (14.0% to 24.4%) or low‐risk individuals (% IA = 20.6% (14.7 to 27.5) over 2020 to 2030), with ART scale‐up among KPs being most efficient.ConclusionsClients of FSWs play a fundamental role in HIV transmission in SA. Addressing the HIV prevention and treatment needs of KPs in generalized HIV epidemics is central to a comprehensive HIV response.
Morphological similarity and dental homologies in two sigmodontine rodents (Mammalia, Cricetidae) from different tribes: A topological analysis to explore convergence
Authors: Barbière Franck , Ronez Christophe , Ortiz Pablo E. , Pardiñas Ulyses F. J. 
Published: February 2021

AbstractWe present a topological analysis of the third upper molars (M3) using the recently developed ICAMER nomenclatural system as a way to understand the dental morphological similarity in sigmodontine rodents, the most speciose subfamily of cricetids. The method is explored inScapteromys aquaticusandAbrothrix olivacea, taxa belonging to two diverse tribes, Akodontini and Abrotrichini, respectively, which exhibit high similarity regarding several craniodental traits as well as external anatomy. Both species show morphologically similar M3 in adults characterized by cylindrification and the isolation of a large central fossette arising from the marginal fusion of the anterior and posterior lobes. The results indicate that, before the wear, these rodents have a strongly different topological pattern at the cuspal level, mostly involving production of the connection between the main cusps. The central fossette derives from the isolation of part of the metaflexus inScapteromys, while inAbrothrixit originates from the hypoflexus. The topological analysis provides a new approach to sigmodontine systematics, including the ability to detect diagnostic characters of both tribes. More important, it constitutes a new step toward an integrative phylogeny of fossil and living cricetids.
Whole‐genome analysis to describe a human adenovirus D8 conjunctivitis outbreak in a tertiary hospital
Authors: Miro Elisenda , Del Cuerpo Margarita , Rubio Marc , Berengua Carla , Español Montserrat , Marin Pilar , Vela Jose I. , Pomar Virginia , Gutierrez Cristina , Navarro Ferran , Rabella Núria 
Published: February 2021

AbstractConjunctivitis is a frequent ocular disorder caused by human adenoviruses (HAdVs). Only a few of the 45 HAdV‐D species are associated with epidemic keratoconjunctivitis, including HAdV‐D8. Nosocomial outbreaks due to HAdV‐D8 have been rarely described, because keratoconjunctivitis cases are clinically diagnosed and treated without having to characterize the causative agent. Moreover, molecular typing is tedious when using classical techniques. In this study, a hospital outbreak of conjunctivitis caused by HAdV‐D8 was characterized using the recently developed whole‐genome sequencing (WGS) method. Of the 363 patients attending the Ophthalmology Department between July 13 and August 13, 2018, 36 may have acquired intrahospital conjunctivitis. Also, 11 of 22 samples sent to the Virology section were selected for WGS analysis. The WGS results revealed that 10 out of 11 HAdV‐D8 strains were closely related. The remaining strain (Case 28) was more similar to a strain from an outbreak in Germany obtained from a public sequence database. WGS results showed that outbreak HAdV‐D8 strains had a minimum percentage of identity of 94.3%. WGS is useful in a clinical setting, because it avoids carrying out viral culture or specific polymerase chain reaction sequencing. The public availability of sequence reads makes it easier to compare clusters in circulation. In conclusion, WGS can play an important role in standard routines to describe viral outbreaks.
An accurate edge‐based FEM for electromagnetic analysis with its applications to multiscale structures
Authors: Zhang Yangfan , Wang Pengfei , Li Wenping , Yang Shunchuan 
Published: February 2021

AbstractThis paper introduces an accurate edge‐based smoothed finite element method (ES‐FEM) for electromagnetic analysis for both two‐dimensional cylindrical and three‐dimensional Cartesian systems, which shows much better performance in terms of accuracy and numerical stability for mesh distortion compared with the traditional FEM. Unlike the traditional FEM, the computational domain in ES‐FEM is divided into non‐overlapping smoothing domains associated with each edge of elements, triangles in two‐dimensional domain and tetrahedrons in three‐dimensional domain. Then, the gradient smoothing technique is used to smooth the gradient components in the stiff matrix of the FEM. Several numerical experiments are carried out to validate its accuracy and numerical stability. Results show that the ES‐FEM can obtain much more accurate results compared with the traditional FEM and is almost independent of mesh distortion.
Automated adaptive TFSF method for solving time domain Maxwell's equations
Authors: Shah Vaibhav , Karuppanasamy Anandhanarayanan , Chatterjee Avijit 
Published: February 2021

AbstractThe total field–scattered field (TFSF) formulation is quite popular for solving Maxwell's equations in finite difference time domain (FDTD) and finite volume time domain (FVTD) methods. Here a fixed TFSF interface around the scattering body is employed to separate the total field (TF) cells and scattered field (SF) cells. This interface is selected based on experience as it is assigned prior to the solution, and, therefore, the solution accuracy may not be optimal. In the present work, a novel automated adaptive total field–scattered field (ATFSF) method is proposed for accurately computing the electromagnetic scattering by complex‐shaped metal objects excited by an external plane wave. In the proposed method, an algorithm is devised to dynamically identify the TF cells and the SF cells, to be solved using TF and SF methods, respectively, using intensity of electromagnetic (EM) wave. The algorithm is tested in a 2‐D spectral volume time domain (SVTD) framework for solving electromagnetic scattering, and the predicted surface current/radar cross section is compared against the SF, TF, and the conventional TFSF methods. It is seen that the present method improves the solution accuracy significantly.
Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
Authors: Kane Cynthia J. M. , Douglas James C. , Rafferty Tonya , Johnson Jennifer W. , Niedzwiedz‐Massey Victoria M. , Phelan Kevin D. , Majewska Ania Katarzyna , Drew Paul D. 
Published: February 2021

AbstractFetal alcohol spectrum disorders (FASD) are alarmingly common, result in significant personal and societal loss, and there is no effective treatment for these disorders. Cerebellar neuropathology is common in FASD and causes aberrant cognitive and motor function. Ethanol‐induced neuroinflammation is believed to contribute to neuropathological sequelae of FASD, and was previously demonstrated in the cerebellum in animal models of FASD. We now demonstrate neuroinflammation persists in the cerebellum several days following cessation of ethanol treatment in an early postnatal mouse model, with meaningful implications for timing of therapeutic intervention in FASD. We also demonstrate by Sholl analysis that ethanol decreases ramification of microglia cell processes in cells located near the Purkinje cell layer but not those near the external granule cell layer. Ethanol did not alter the expression of anti‐inflammatory molecules or molecules that constitute NLRP1 and NLRP3 inflammasomes. Interestingly, ethanol decreased the expression of IL‐23a (P19) and IL‐12Rβ1 suggesting that ethanol may suppress IL‐12 and IL‐23 signaling. Fractalkine‐fractalkine receptor (CX3CL1‐CX3CR1) signaling is believed to suppress microglial activation and our demonstration that ethanol decreases CX3CL1 expression suggests that ethanol modulation of CX3CL1‐CX3CR1 signaling may contribute to cerebellar neuroinflammation and neuropathology. We demonstrate ethanol alters the expression of specific molecules in the cerebellum understudied in FASD, but crucial for immune responses. Ethanol increases the expression of NOX‐2 and NGP and decreases the expression of RAG1, NOS1, CD59a, S1PR5, PTPN22, GPR37, and Serpinb1b. These molecules represent a new horizon as potential targets for development of FASD therapy.
Carbamazepine, oxcarbazepine, and lacosamide as adjunctive analgesics: a review of the literature
Authors: Reinert Justin P. , Nuon Katelin , Veronin Michael A. 
Published: February 2021

AbstractThe pursuit of ideal multi‐modal analgesic strategies remains ongoing, though the use of select antiepileptic drugs as adjunctive analgesics to opioids has been previously studied and postulated to have varying degrees of success. The objective of this review was to determine the efficacy and safety of select antiepileptic drugs as adjunctive analgesics in an update to a previously published Cochrane review on the subject in 2013. A comprehensive literature review was conducted using PubMed, MEDLINE, Scopus, and Web of Science between January 2013–August 2020 using: “carbamazepine” OR “oxcarbazepine” OR “lacosamide” AND “analgesia”. The use of one of the study drugs as an adjunctive analgesic to opioids was included. Thirty‐five articles were identified through database inquiries, though only two reports met inclusion criteria, with one focusing on carbamazepine and one focusing on oxcarbazepine. No articles detailing lacosamide in accordance with the scope of this review were identified. Both carbamazepine and oxcarbazepine demonstrated safety and efficacy as adjunctive analgesics across numerous indications, including postoperative neuropathies and neuropathies associated with spinal cord injuries. While the search for a universal or definitive multi‐modal pain management regimen remains elusive, carbamazepine and oxcarbazepine have demonstrated clinical utility in pain syndromes beyond their historic relegation to trigeminal neuralgia. Limited evaluation and data has been derived regarding the use of carbamazepine, oxcarbazepine, and lacosamide since the previous Cochrane review in 2013. The results of this review solidify the need for continued future investigation. Additional data is necessary to define the role of lacosamide for this indication.
Influence of chitosan on the emulsifying properties of egg yolk hydrolysates: study on creaming, thermal and oxidative stability
Authors: Chang Cuihua , Gao Yang , Su Yujie , Gu Luping , Li Junhua , Yang Yanjun 
Published: February 2021

AbstractBACKGROUNDEgg yolk, as a natural emulsifier, is widely used in high‐oil‐phase food systems, such as mayonnaise and salad. However, the application of egg yolk in an oil‐in‐water system is still limited due to poor emulsifying stability. To improve the emulsifying capacity of egg yolk, the effect of chitosan addition sequence and concentration on emulsifying properties (creaming stability, thermal tolerance and oxidation resistance) of egg yolk hydrolysates were investigated.RESULTSStacking sequence of multilayer materials has an influence on properties of composite emulsions. The composite emulsions with egg yolk hydrolysis dominate at the interface (functioning on reducing interfacial tension), and chitosan layered on the surface (providing steric hindrance) displayed better stability. Little chitosan addition (0.5 g × kg−1, w/w) was unhelpful for the dispersion of emulsion droplets as a result of bridging flocculation. At a chitosan concentration of 2 g kg−1 (w/w), the composite emulsion possesses the best stability. When chitosan concentration was higher than 2 g kg−1 (w/w), depletion flocculation would occur. Hydrolyzed egg yolk prepared composite emulsions possessed better thermal resistance, but with poorer oxidative stability as compared to natural egg yolk. In combination with chitosan it also displayed a negative effect on the oxidative stability of the emulsion system.CONCLUSIONThe research revealed the effect of chitosan addition on the physical and chemical stability of emulsions prepared with egg yolk hydrolysates. The results could provide guidance on expanding the application of egg yolk as an emulsifier in water‐abundant food systems such as beverages. © 2021 Society of Chemical Industry.
Daily Brazilian green propolis intake elevates blood artepillin C levels in humans
Authors: Ding Jiangli , Matsumiya Tomoh , Hayakari Ryo , Shiba Yuko , Kawaguchi Shogo , Seya Kazuhiko , Ueno Kayo , Imaizumi Tadaatsu 
Published: February 2021

AbstractBACKGROUNDPropolis is a natural product collected by worker bees from a variety of plant species. As a type of propolis, Brazilian green propolis contains a large amount of artepillin C. Artepillin C is a cinnamic acid derivative and has been shown to have a wide variety of biological functions, including anti‐inflammatory, antiviral and antitumor activities, in both cell culture and animal models. However, how propolis is digested and absorbed remains to be elucidated. Moreover, blood artepillin C levels after propolis intake have not been shown in human studies.RESULTSA randomized, single‐blind placebo‐controlled study on the effect of Brazilian green propolis on serum artepillin C levels was conducted with healthy volunteers. The participants (n = 133) were randomly allocated in an approximately 2:1 ratio to two groups: propolis (n = 91) and placebo (n = 42). The participants took daily propolis or placebo, and blood tests were performed on day 0 (before propolis intake) and days 1, 3 and 7. Artepillin C was detected in serum in almost all individuals in the propolis groups. No serum artepillin C was detected in the placebo group. Serum artepillin C levels in the female group tended to be higher than those in the male group. In the female group, menstrual status was unrelated to serum artepillin C levels.CONCLUSIONThese results suggested that propolis intake might be more effective for females than for males. © 2021 Society of Chemical Industry
Comparison of freshness prediction method for salmon fillet during different storage temperatures
Authors: Jia Zhixin , Shi Ce , Zhang Jiaran , Ji Zengtao 
Published: February 2021

AbstractBACKGROUNDMany new forecasting models have been applied to fish freshness prediction like support vector regression (SVR) and radial basis function neural network (RBFNN). In this study, RBFNN, SVR, and Arrhenius models were established and compared for predicting and evaluating the quality of salmon fillets during storage at different temperatures, based on thiobarbituric acid (TBA), total volatile basic nitrogen (TVB‐N), total viable counts (TVCs), K value, and sensory assessment (SA).RESULTSThe TBA, TVB‐N, TVC, and K values increased during storage whereas SA decreased. Residuals of the three models are random and irregular, indicating that these models were suitable for predicting the freshness of salmon fillets. The RBFNN predicted quality of salmon fillets stored at different temperatures with relative errors all within ±5% (except for the TVC value at day 6). Relative errors of the SVR model for predicting TVB‐N and K value were within 10%, while the relative errors of the Arrhenius model fluctuated greatly (ranging from ±0.46 to ±38.29%) and most of it exceeded 10%. RBFNN model had the best predictive performance by comparing the residual and relative errors of the three models.CONCLUSIONRBFNN is a promising method for predicting the freshness of salmon fillets stored at −2 to 10 °C in the cold chain. © 2021 Society of Chemical Industry
Hyperbranched aromatic polyamide modified magnetic nanoparticles for the extraction of benzoylurea insecticides
Authors: Liu Zikai , Xu Qinqin , Yan Chen , Li Jing , Zhou Wenfeng , Gao Haixiang , Zhang Sanbing , Lu Runhua 
Published: February 2021

AbstractHerein, a novel hyperbranched aromatic polyamide‐coated magnetic sorbent was prepared by in situ polymerization on the surface of amino‐functionalized Fe3O4 nanoparticles. The magnetic sorbent was characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, elemental analysis, Brunauer–Emmett–Teller measurement, and X‐ray photoelectron spectroscopy, etc. The new magnetic sorbent was used in the magnetic solid‐phase extraction for the detection of seven benzoylurea insecticides. Under optimum conditions, low method detection limits (0.56‐1.20 ng/mL), acceptable coefficient of determination (0.9967‐0.9996), wide linear ranges (2.5‐500.0 ng/mL), and good repeatability (intraday: 2.0‐7.3%; interday: 1.9‐9.2%) were achieved. The magnetic solid‐phase extraction method based on the new magnetic sorbent showed good reliability in the analysis of seven benzoylurea insecticides in real water samples, as the relative recoveries were in the range from 80.1 to 116.3% with satisfactory RSDs (0.1‐9.8%). By means of density functional theory and semiempirical quantum mechanical, the binding configuration and interaction energy of hyperbranched aromatic polyamide and benzoylurea insecticides were calculated. The result of theoretical calculation revealed that the adsorption of benzoylurea insecticides by hyperbranched aromatic polyamide was derived from hydrogen bonding and π‐π stacking. The contribution of π‐π stacking was greater than that of hydrogen bond, which was confirmed by energy decomposition analysis.
Improvement of Pulmonary Function in Cystic Fibrosis Patients following Endoscopic Sinus Surgery
Authors: Kawai Kosuke , Dombrowski Natasha , Sawicki Gregory S. , Adil Eelam A. 
Published: February 2021

Objective/HypothesisTo compare pre‐and post‐operative pulmonary function relative to disease severity in cystic fibrosis (CF) patients following endoscopic sinus surgery (ESS).Study DesignRetrospective chart review.MethodsPatients with CF who underwent ESS between January 1996 and July 2018 were identified, with subsequent study exclusions based upon surgical indications or incomplete records. CF disease severity was based upon percentage predicted of forced expiratory volume in 1 second (%FEV1) with <40% considered severe disease, 40% to 70% as moderate disease, and >70% as mild disease. The changes in %FEV1 before and after ESS were examined using multivariable mixed‐effects models controlling for age, gender, genotype, medications, nutritional status, diabetes status, microbiology results, extent of surgery, and number of surgeries.ResultsA total of 427 surgeries were performed in 188 patients during the study period. Mean age at first ESS was 12.7 years (SD 6.0 years, range 4–38) and 54.8% were females. The effect of ESS varied by severity of lung disease. After surgery, %FEV1 increased by 8.1% (95% CI: 2.3, 13.9%) among patients with severe lung disease and by 3.0% (95% CI: 0.7, 5.2%) among patients with moderate disease. %FEV1 also increased by 7.3% (95% CI: 4.2, 10.5%) among patients with mild disease whose %FEV1 value was 70% to 80% at baseline. No improvement was observed in patients with a baseline %FEV1 >80%.ConclusionsWhen controlling for important confounding factors, lung function improved following ESS among CF patients with severe and moderate disease and in select patients with mild disease. This improvement was sustained at 12 months following surgery.Level of Evidence4 Laryngoscope, 131:1930–1938, 2021