bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid
Authors: Little Blake 
Published: March 2021

Stories of expressions of trans, gender fluid, non-binary, Two Spirit, and other diverse gender identities circulate widely, adding to a complex and oft-times challenging web of shifting societal responses to gender. My photographic eye is guided by an aesthetic of simplicity, distillation & clarity. I want to apply this eye to make visible the many ways we read photographs and their subject matter (imagined and real) but particularly via a collaborative process as filtered through the voices of the people who posed for these photographs.
Transgender identification, representation and image dissemination increasingly occupy the collective imagination and are reinforced by media headlines. Even as more and more trans, gender fluid, non-binary, and Two Spirit people are coming out in the public eye, the act of realizing/representing/revealing/ exposing/ exhibiting oneself through photography is a brave act, a form of defiance for a new wave of gender fluid pioneers reclaiming a broader live presence and virtual presence via social media. In the process, difference is being normalized.
Circulating miR-30b levels increase during male puberty
Authors: Varimo Tero , Wang Yafei , Miettinen Päivi J , Vaaralahti Kirsi , Hero Matti , Raivio Taneli 
Published: March 2021

Objective
The role of miRNA as endocrine regulators is emerging, and microRNA mir-30b has been reported to repress Mkrn3. However, the expression of miR-30b during male puberty has not been studied.

Design and methods
Circulating relative miR-30b expression was assessed in sera of 26 boys with constitutional delay of growth and puberty (CDGP), treated with low-dose testosterone (T) (n =11) or aromatase inhibitor letrozole (Lz) (n =15) for 6 months and followed up to 12 months (NCT01797718). The associations between the relative expression of miR-30b and hormonal markers of puberty were evaluated.

Results
During the 12 months of the study, circulating miR-30b expression increased 2.4 ± 2.5 (s.d.) fold (P = 0.008) in all boys, but this change did not correlate with corresponding changes in LH, testosterone, inhibin B, FSH, or testicular volume (P = 0.25-0.96). Lz-induced activation of the hypothalamic–pituitary–gonadal (HPG) axis was associated with more variable miR-30b responses at 3 months (P < 0.05), whereas those treated with T exhibited significant changes in relative miR-30b levels in the course the study (P < 0.01–0.05).

Conclusions
Circulating miR-30b expression in boys with CDGP increases in the course of puberty, and appears to be related to the activity of the HPG axis.
Reflexive Impersonal Constructions Expressing an Arbitrary Agent in Slovenian
Authors: Uhlik Mladen , Žele Andreja 
Published: March 2021

The article presents formal, semantic, and pragmatic features of Slovenian subject impersonal reflexive constructions, e. g. Nekoč se je veliko delalo ‘Back in the day, one used to work a lot’. Constructions with unexpressed arbitrary agents should be distinguished from sentences in which the nominative agent has been omitted, but can be determined from the context. Subject impersonal reflexive constructions use the reflexive forms of non-reflexive verbs. In such constructions, the morpheme se is a grammaticalized element that does not express a reflexive action. The constructions under discussion can express habitual or iterative actions performed by a non-expressed human agent and can also have a deontic meaning. Reflexive constructions with arbitrary agents mainly involve verbs denoting conscious human actions and activities, which sets them apart from weather impersonals or subjectless constructions describing physiological states. Subject impersonals, characteristic of South Slavic and West Slavic languages, are parallel to those in which the arbitrary agent is expressed lexically (Nekoč so ljudje veliko delali ‘Back in the day, people used to work a lot’). We compare subject impersonals with other impersonal and passive constructions in Slovenian and, at the same time, contrast their features with similar constructions in other South Slavic languages and Russian.
Comment on: Problematic online gaming and the COVID-19 pandemic – The role of exergames
Authors: Viana Ricardo B. , Vancini Rodrigo L. , Silva Wellington F. , Morais Naiane S. , de Oliveira Vinnycius N. , Andrade Marília S. , de Lira Claudio A. B. 
Published: March 2021

AbstractAlthough significant increases in gaming may not always be beneficial, exergames (a new generation of video games also known as exergaming or active video games) appear as an alternative, feasible, attractive, and safe way to perform physical exercise for most clinical and nonclinical populations. Therefore, it is important to recognize that exergames can be considered a useful tool for coping with the COVID-19 outbreak and the recommended social distancing period.
Multiplatform Application Technology – Based Heutagogy on Learning Batik: A Curriculum Development Framework
Authors: Widiaty Isma , Riza Lala Septem , Abdullah Ade Gafar , Mubaroq Sugeng Rifqi 
Published: March 2021

This study aimed to design a batik learning medium for vocational high school students in based on multiplatform. The application made was expected to support heutagogy approach – based learning and to deal with the development of science and technology integrated in the curriculum of vocational high schools. The application developed, namely e-botik, was an integration of several previously-designed applications using Code ignitor (CI) framework. The database used was My-SQL. It is commonly known that Code igniter is an open source web application framework utilized to create dynamic PHP applications. In this study, e-botik consisted of three main components including interface, database, and application programming interface (API). Some of the applications combined were ARtikon_joyful (Android-based), Video Kasumedangan Batik (movie player), Nalungtik Batik (desktop-based), Digi_Learnik (web-based), Batik UPI (manual), Batik Cireundeu (manual), and Lembar Balik (manual). The combination proceeded web-based so that it was compatible with various operating systems. The application (e-botik) was designed and then tested. The test was performed through whitebox testing and blackbox testing. The results of the test showed that it ran well and was able to be used a batik learning media. It is expected that students can utilize e-botik in selecting topics of learning batik in accordance with their competences and needs. This condition enables e-botik to support learning batik through heutagogical approach. In addition, the application was also validated in terms of both system and usage aspects.
Pulgar en gatillo, pulgar en resorte, o tenosinovitis estenosante del pulgar pediátrico
Authors: Migoya Nuño Alfonso , Fraind Maya Gabriel , Loyo Soriano Luis Eduardo 
Published: March 2021

El pulgar en gatillo es una patología de etiología idiopática en la que el tendón flexor largo del pulgar se encuentra engrosado proximal a la polea A1 generando una discrepancia de tamaño que impide el deslizamiento del tendón a través dicha polea, Se presenta de manera global en 3 de cada 1000 RNV siendo mas común en población hispana, su diagnóstico es clínico por lo que no se requieren estudios de extensión, la resolución espontánea de esta patología se presenta en el 30% de los casos aproximadamente, porcentaje que puede aumentar si se realiza terapia física; sin embargo los pacientes que no presentan mejoría deben ser referidos al ortopedista pediátrico para recibir tratamiento quirúrigico.
Influence of thin-layer soil analogues on the production process of lettuce plants in intensive artificial-light culture
Authors: Udalova O. R. , Anikina L. M. , Khomyakov Yu. V. , Vertebniy V. E. , Dubovitskaya V. I. , Panova G. G. 
Published: March 2021

Relevance.The solution to the problem of providing the population of our country with high - quality plant production all year round is possible when creating high-tech automated phytotechnological complexes based on innovative, resource-saving technologies for growing plants in an artificial climate, including the development of a new generation of root inhabited thin-layer analogues of soils.Materials and methods. The research was carried out under controlled conditions of intensive artificial-light culture, when growing lettuce plants of the Typhoon variety on thin - layer analogs of soil of various composition and a low-volume soil analogue based on high-moor peat with a low degree of decomposition "Agrofit", selected as a reference for comparison, in plant growing light equipment developed at Agrophysical Institute.Results. Evaluation of the influence of thin-film analogues of the soil based on the suspensions Cambrian clay, and /or sapropel in different ratios on the production process of lettuces showed when compared with control (hydrophilic fabric): a positive tendency to increase of height, number of leaves per plant; a significant increase in wet mass by 25-35%, dry mass in 54-80%, percent dry matter in 16-36%; increase of leaf area and photosynthetic capacity at 20-36%, net productivity of photosynthesis by 16-45%; a significant or in a form of tendency to increase in the content of potassium by 14-17%, calcium by 27-35%, zinc by 29-53% and disaccharides by 28-68%. In comparison with the low-volume analogue of the soil based on high-moor peat of a low degree of decomposition "Agrophyte" (standard), it was found an increase in the form of a pronounced positive trend in growth indicators - the height and number of leaves. wet, dry mass of plants, percentage of dry matter; net productivity of photosynthesis, a reliable or in form of trend to increase in leaf area, photosynthetic potential by 20-30%; an increase in the content of mineral elements in lettuce leaves. Possible reasons for the lower productivity of lettuce plants in the control were determined, and it associated with an increase in water intake in leaf tissues against the background of the absence of additional mineral and / or organic nutrition. The content of heavy metals and nitrates did not exceed the maximum permissible concentration (MPC) in all variants. All thin-layer analogs of the soil with the application of suspensions of various compositions can be recommended for growing lettuce in any cultivation facilities in conditions of intensive artificial-light culture.
Biofortification of chervil with selenium
Authors: Kharchenko V. A. , Golubkina N. A. , Moldovan A. I. , Caruso G. 
Published: March 2021

Relevance.Production of functional food with high levels of antioxidant status and selenium is essential for human protection against viral and cardiovascular diseases as well as cancer.Methods.Evaluation of the efficiency in foliar sodium selenate biofortification (25. 50 and 75 mg Se/L) was achieved on three chervil genotypes.Results.Intervarietal differences in biofortification level was demonstrated: from 15.5 to 31.1 for 25 mg Se/L dose; from 36.9 to 64.6 for 50 mg Se/L dose; and from 72.9 to 130 for 75 mg Se/L dose. At the chosen doses, selenium supply did not affect significantly the yield, antioxidant properties and photosynthetic content of chervil. Total antioxidant activity was in the range from 30 to 42 mg GAE/g d.w., phenolics content from 9 to 13 mg GAE/g d.w, flavonoids from 5 to 12 mg-eq quercetin/g d.w., ascorbic acid from 33 to 66 mg/100 g fresh w. High levels of carotene were a typical feature of Se fortified and non-fortified chervil. A direct correlation was recorded between phenolics content and total antioxidant activity (r=+0.954, P<0.01), and between water soluble compounds and nitrates accumulation (r=+0.920, P<0.01). Biofortification with selenium did not affect significantly the mineral content of plants. Consumption of 100 g of fresh chervil leaves, fortified with selenium, provides from 50 to 75% of the adequate selenium consumption level and from 16 to 20% of potassium. Taking into account that both selenium and potassium normalize heart activity, the new functional food product may be recommended for prophylactics and treatment of cardiovascular diseases and for the human selenium status optimization.
Treatment Adherence to Drug Therapyin Patients with Stable Coronary Artery Disease During the COVID-19 Pandemic
Authors: Martsevich S. Y. , Lukina Y. V. , Zharkova E. D. , Kutishenko N. P. 
Published: March 2021

The new coronavirus infection (COVID-19) pandemic and the subsequent quarantine measures, particularly home isolation of the population, could have seriously affected the quality of pharmacotherapy and adherence to it by patients with chronic non-communicable diseases.Aim. To assess the dynamics of adherence to pharmacotherapy by patients with stable coronary artery disease (SCAD) in self-isolation during the COVID-19 pandemic.Material and methods. To accomplish the aim of the study, we selected 39 patients with SCAD who previously completed the ALIGN study, the purpose of which was to align patients’ medical therapies according to current clinical guidelines. From May 05, 2020, to May 14, 2020, a telephone survey was conducted of 39 patients with SCAD (37, 94.8%) males, mean age 67.6±8.5 years). After one year of participation in the ALIGN study, 87.1% of the patients were adherent to their prescribed pharmacotherapy. Adherence (overall and to specific medications) was assessed by means of the original adherence scale, which made it possible to identify violations in taking medications (non-adherence to the intake regime or discontinued intake of medications), and the main reasons for adherence violation were established. Adherence registered during the telephone survey at the time of the COVID-19 pandemic was compared to that obtained during the last time the patient participated in the ALIGN study.Results. During the period of home isolation, a substantial decline in the adherence of patients to pharmacotherapy was revealed. The percentage of adherent patients decreased from 87% to 54% due to an increase in the number of patients who stopped taking several or all of the recommended drugs during home isolation (p=0.024). The overall rate of adherence during the COVID-19 pandemic appeared to be even worse than before the start of the ALIGN study. A comparative analysis of subgroups with and without a decline in adherence revealed a trend suggesting that higher patient education (p=0.067) or previous percutaneous coronary intervention (p=0.063) can be considered a protective factor associated with fewer violations in adherence during the COVID-19 pandemic. Analysis of adherence to specific drugs showed that during self-isolation there was a decrease in adherence to antiplatelet drugs (p=0.047) and to statins (p=0.055). Adherence to beta-blockers, renin-angiotensin-aldosterone system inhibitors and dihydropyridine calcium antagonists remained unchanged.Conclusion. In patients with SCAD during the period of home isolation in the COVID-19 pandemic and associated difficulties in contacting the attending physician, there was a decline in adherence and an increase in the number of patients who stopped taking several or all prescribed drugs.
Bone and Body Composition Analyses by Dxa in Adults With Gh Deficiency: Effects of Long-term Replacement Therapy
Authors: Rossini Alessandro , Lanzi Roberto , Galeone Carlotta , Pelucchi Claudio , Pennacchioni Mario , Perticone Francesca , Sirtori Marcella , Losa Marco , Rubinacci Alessandro 
Published: March 2021

Abstract
Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD.Methods: Data from 138 patients with AGHD (34.3 ± 14.3 years, 48 women and 90 men) treated with rhGH for a period of at least 3 years up to a maximum of 10 were retrospectively collected. Bone mineral density (BMD) at the lumbar spine, femur, and radius, and total and truncular body composition were evaluated by dual energy X-ray absorption (DXA) before and during treatment. Clinical and laboratory evaluations were performed before and during the treatment period on an annual basis.Results: Lumbar spine BMD consistently increased in males, while in females decreased after a transient improvement observed during the first 4 years of therapy. There were no significant changes in femoral BMD in either sexes, while a progressive increase at radius was observed only in males. Lean mass significantly increased in both sexes, while fat mass decreased only in males.Conclusions: In AGHD patients long-term rhGH replacement therapy induces a positive effect with regard to bone mass and body composition. A sexual dimorphism in the response to treatment is evident, with males displaying more favorable outcome.
Facile Synthesis of Nanostructured Zno-rgo Based Graphene and It’s Application in Waste Water Treatment
Authors: Ramadan Rania , Abdel-Aal Seham K. 
Published: March 2021

Abstract
In the present work graphene oxide GO prepared by chemical exifliation of graphite using Hummer’s method. A facile and green synthesis of ZnO-rGO nanocomposite was performed via Alovera plant extract. The characterization tools (XRD-FTIR- FESEM-TEM- AFM) proved the formation of single phase of ZnO-rGO nanocomposite. Since the environmental contamination caused by Cd(II) ion is a world issue as it has a harmful effect especially on the human health and environment. Subsequently, our goal in this work is to find an accurate method for detection and adsorption of toxic Cd(II). ZnO and ZnO-rGO nanocomposites are prepared for removing Cd(II) and on behalf of increasing its removal efficiency, GO is added. The results showed a great improvement in removal efficiency reached up to 90% at pH 6 after 90 min. the structure and surface of prepared samples studied through XRD, FTIR, FESEM and AFM.
Spatiotemporal Expression Patterns of Critical Genes Involved in FGF Signaling during Morphogenesis and Odontogenesis of Deciduous Molar in Miniature Pig
Authors: Guo Wenwen , Zhang Ran , Hu Lei , Wang Jiangyi , Wang Fu , Wang Jinsong , Zhang Chunmei , Wu Xiaoshan , Wang Songlin 
Published: March 2021

Abstract
Background
The fibroblast growth factor (FGF) pathway plays important role in epithelial-mesenchymal interactions during tooth development. However, how the ligands, receptors, and inhibitors of the FGF pathway get involved into the epithelial-mesenchymal interactions are largely unknown in miniature pigs, which can be used as large animal models for similar tooth anatomy and replacement patterns to humans.
Results
In this study, we investigated the spatiotemporal expression patterns of critical genes encoding FGF ligands, receptors, and inhibitors in the third deciduous molar of the miniature pig at the cap, early bell, and late bell stages. With the methods of fluorescence in situ hybridization and real time RT-PCR, it was revealed that the expression of Fgf3, Fgf4, Fgf7, and Fgf9 mRNAs were located mainly in the dental epithelium and underlying mesenchyme at the cap stage. The expression levels of Fgf3 and Fgf7 in the mesenchyme were upregulated in the early bell stage and then concentrated in the odontoblasts layer in the late bell stage. In contrast, the expression levels of Fgf4 and Fgf9 in the mesenchyme were downregulated from the cap to bell stage. Gene expression analysis also suggested that Fgfr1 and Fgfr3 were the major receptors regulating dental calcification. Furthermore, the inhibitor-coding genes Sprouty 2 and Sprouty 4 were expressed in the epithelium and mesenchyme in the three stages, indicating that elaborate regulation occurred during dental morphogenesis.
Conclusions
The spatiotemporal expression pattern of FGF signaling provides the foundation for future studies aiming to fine-tune dental morphogenesis and odontogenesis by controlling the interactions between the dental epithelium and mesenchyme, thereby promoting tooth regeneration in large mammals.
Design and Analytical Evaluation of A High Resistance Sensitivity Bolometer Sensor Based on Plasmonic Metasurface Structure
Authors: Hamouleh-Alipour Abbas , Mir Ali , Farmani Ali 
Published: March 2021

Abstract
Bolometer sensors are prominent and excellent choice in technology because they do not need cooling. The trade-off between high sensitivity, fast response time, and strong light absorption is a key important challenge in bolometer sensors. Here, the bolometric effect for a high resistance sensitivity plasmonic sensing of total and profile infusion of radiation is studied for the proposed bolometer sensor based on plasmonic multilayer structure at 26° C. In the present study, by generating strong coupling condition between incident wave and surface plasmon polaritons (SPPs), a very narrow absorption spectra with high figure of merit (FoM) is achieved. The analytical model and numerical simulation are fulfilled based on the transfer matrix method (TMM) and 3-D finite-difference time-domain (FDTD), respectively. The narrow absorption spectra that generate by strong coupling with SPPs heats the silver thin film that leads to variation in temperature and supports TE surface mode. This temperature change rectifies the resistance of the metal thin film by the bolometric effect. So, optical characteristics of the proposed metasurface bolometer sensor, including quality factor (Q), sensitivity, and figure of merit (FoM) are calculated that Max sensitivity, FoM, and Q are 17.2 RIU-1, 530 and 434.5, respectively. Finally, we analytically simulate the temperature coefficient of resistance (TCR) in terms of wavelength and refractive index of analyte (na) that this resistance change can be monitored by an external electric model. The proposed plasmonic multilayer configuration is a very compact footprint structure that achieved high resistance sensitivity and FoM in comparison with any previous reports. This proposed thermal, optical, and electric plasmonic metasurface bolometer sensor can be used in different applications such as biophysics, biology, and environmental science.