bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Investigation on the Triaxial Compression Behavior of Large-Scale Jointed Coal
Authors: Wang Xiaoqing , Gao Fuqiang 
Published: April 2021

Abstract
Accurate estimation of the triaxial compression behavior of coal mass is essential for coal mining. In this study, a numerical synthetic rock mass method was used to study the triaxial compression behavior of coal mass. The jointed-coal specimens were constructed based on in-situ joint measurements and microparameter calibration against laboratory tested data. A series of triaxial compression tests on jointed-coal specimens with different loading orientations and confining pressures were performed to obtain joint and confining-pressure effects and to reveal the related failure mechanism. The results suggest that jointed coal has a strong joint effect and confining-pressure effect. Joints weaken the strength and elastic modulus, reduce the lateral deformation, and affect the geometries of the shear-rupture surface. With increase in the confining pressure, the peak strength and residual strength increase but the elastic modulus remains stable; the lateral strain decreases, especially at low confining pressure; the mechanical behavior transitions from brittleness to ductility; the failure mode transitions from shear-rupture surface to plastic flow; and the joint effect diminishes and even disappears. The shear-rupture surface is formed by the combined effect of shear stress and joints at low confining pressure, and the contribution of joints decreases with increase in confining pressure.
Catastrophic Mechanism and Stability Analysis of Jiangdingya Landslide in Zhouqu County, Gansu Province, China
Authors: Ma Tianzhong , Yang Xiaohui , Zhang Weixiong , Sun Chendong 
Published: April 2021

Abstract
On July 12, 2018, a large-scale landslide occurred in the Jiangdingya area, Nanyu Town, Gansu Province, China. According to remote sensing interpretation and field investigation, the landslide volume is about 480×104 - 550×104m 3 , which caused the Bailongjiang River to be blocked and the water level to rise, forming a dammed lake, flooding Nanyu Town. The landslide is characterized by chain disasters, which poses a serious threat to the ecological security of the upper reaches of the Yangtze River. In this paper, the catastrophic mechanism of Jiangdingya landslide is analyzed, and the stability of the slope is studied. According to the disaster characteristics, comprehensive safety control measures are put forward. The study shows that the occurrence of landslides is closely related to geological structure, environmental evolution, precipitation infiltration, earthquake damage and human activities, among which geological structure is the decisive factor and earthquake and rainstorm are the inducing factors. Under the action of river erosion and precipitation infiltration, it is easy to trigger the revival of new large-scale landslides. Therefore, it is necessary to take risk management measures for landslides, strengthen the risk identification of landslide disasters, and avoid the recurrence of serious geological disasters. The research results of this paper are of great significance to the prevention and control of chain disasters and the comprehensive treatment of slopes.
Adipose Tissue is a Predictor of 30-days Mortality in Patients with Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella Pneumoniae
Authors: ying piaopiao , chen jiajing , ye yinchai , ye jiayong , cai weiyang 
Published: April 2021

Abstract
Background: Prevalence of CRKP bloodstream infection with high mortality has attached physicians' attention. High-VAT and high-SAT were confirmed by previous studies that closely related to increased pneumonia severity, more complications, and higher mortality in COVID-19. Thus, we speculate that CT-quantified body composition may also be connected to all-cause mortality and bacterial clearance in patients with CRKP bloodstream infection. Methods: We investigated the associations of CT-quantified body composition with CRKP bloodstream infectious patients. All of the CT images were obtained at the level of the L3/4 spinal level. The prognostic value of the body composition was analyzed using the Cox regression model, and precise clinical nomograms were established. Results: Factors associated with 30-day all-in hospital mortality included TAT [adjusted odds ratio (OR)=1.028, 95% confidence interval (CI), 1.004–1.053; p = 0.028], age [OR=1.031, 95% CI, 1.001–1.062; p = 0.046] and SOFA score [OR=1.137, 95% CI 1.047–1.235; p = 0.002]. Compared with low-VAT, patients with high-VAT show a strikingly poor prognosis in both 30-day mortality (P=0.0449, Figure 2A) and all-cause mortality (P=0.0048, Figure 2C). The results of TAT were similar with VAT. Conclusions: Our study suggests that CT-derived composition could be a credible and effective alternative to assess the prognosis of patients with BSIs owing to CRKP. CT-quantified total adipose tissue, age and SOFA scores were independently associated with 30-day all-cause mortality in these severe infectious patients, while skeletal muscle did not have obvious statistical significance.
Washing-free Chemiluminescence Immunoassay for Rapid Detection of cTnI in Whole Blood Samples
Authors: Zhao Huan , Su Enben , Huang Li , Zai Yunfeng , Liu Yuan , Chen Zhu , Li Song , Jin Lian , Deng Yan , He Nongyue 
Published: April 2021

Abstract
Background: Chemiluminescence immunoassay (CLIA) has always been a great challenge in detecting whole blood samples without centrifugation because of the interference of red blood cells and low sensitivity. Results: In this scheme, the antigens and erythrocytes in the blood were captured by the antibodies immobilized on the magnetic particles, recognized by another biotin-conjugated cTnI antibody and detected by streptavidin/acridine aster-conjugated PCMS. After magnetic separation, the supernatant was transferred and measured. No significant difference was noted between the cTnI concentrations of the serum samples, plasma samples and whole blood. The prepared PCMS provided more functional areas to conjugate streptavidin and acridinium ester, so the immunoassay has highly sensitive, the limits of blank at 0.012 ng/mL, and functional sensitivity at 0.019 ng/mL with a CV of 20%, and 0.058 ng/mL with a CV of 10%. Total precision of any sample type ranged from 2.62~5.67%. The assay was linear over the studied range of 0.01–50.00 ng/mL, and no hook effect was found when cTnI concentrations reached 1900 ng/mL. No significant interference was noted with the potential endogenous interfering substances. Compared with the commercial kit (Abbott assay kit), the correlation coefficient was 0.9859.Conclusions: A washing-free chemiluminescence immunoassay (CLIA) was established for the rapid detection of cardiac troponin I (cTnI) in human whole blood, using erythrocyte capture antibodies-conjugated magnetic nanoparticles for eliminating the influence of erythrocytes and polychloromethylstyrene microspheres (PCMS) for signal amplification, which showed great potential in clinical application.
Robust synthesis of two-dimensional metal dichalcogenides and their alloys by active chalcogen monomer supply
Authors: Liu Kaihui , Zuo Yonggang , Liu Can , Ding Liping , Qiao Ruixi , Liu Chang , Fu Ying , Liu Kehai , Zhou Xu , Wang Qinghe , Guo Quanlin , Xue Guodong , Wang Jinhuan , Hong Hao , Wu Muhong , Yu Dapeng , Wang Enge , Bai Xuedong , Ding Feng 
Published: April 2021

Abstract
Two-dimensional (2D) transition metal dichalcogenides (TMDs), with their atomic thicknesses, high carrier mobility, fast charge transfer, and intrinsic spin-valley couplings, have been demonstrated one of the most appealing candidates for next-generation electronic and optoelectronic devices. The synthesis of TMDs with well-controlled crystallinity, quality and composition is essential to fully realize their promising applications. Similar to that in III-V semiconductor synthesis, the precise precursor supply is a precondition for controllable growth of TMDs. Although great efforts have been devoted to modulate the transition metal supply, few effective methods of chalcogen feeding control were developed. Herein we report a strategy of using active chalcogen monomer supply to grow TMDs and their alloys in a robust and controllable manner. It is found that at a high temperature, the active chalcogen monomers (such as S, Se, Te atoms or their mixtures) can be controllably released from metal chalcogenides and, thus, enable the synthesis of TMDs (MX2, M = Mo, W; X = S, Se, Te) with very high quality, e.g., MoS2 monolayers exhibit photoluminescent circular helicity of ~92%, comparable to the best exfoliated single-crystal flakes and close to the theoretical limit of unity. More intriguingly, a uniform quaternary TMD alloy with three different anions, i.e., MoS2(1-x-y)Se2xTe2y, was accomplished for the first time. Our mechanism study revealed that the active chalcogen monomers can bind and diffuse freely on a TMD surface, which enables the effective nucleation and reaction, quick chalcogen vacancy healing, and alloy formation during the growth. The chalcogen monomer supply strategy offers more degrees of freedom for the controllable synthesis of 2D compounds and their alloys, which will greatly benefit the development of high-end devices with desired 2D materials.
Modification of heavy metals toxicity by Cyanobacteria Nostoc sp. N27P72 and Nostoc sp. FB71 in Culture Conditions
Authors: Ghorbani Elham , Nowruzi Bahareh , NejadAli Mssomeh , Hekmat Azadeh 
Published: April 2021

Abstract
Purpose: Cyanobacteria are ecologically relevant prokaryotes that can be found in environments contaminated with heavy metals. As their photosynthetic machinery imposes high demands for metals, homeostasis of these micronutrients has been extensively considered in cyanobacteria. So far, most studies have focused on treatment of wastewaters using microalgae leads to remarkable reduction of an array of organic and inorganic nutrients, but what takes place in the extracellular environment when cells are exposed to external supplementation with heavy metals remains largely unknown. Methods: Here, extracellular polymeric substances (EPS) production in strains Nostoc sp. N27P72 and Nostoc sp. FB71 isolated from different habitats are reported and compared. Cultures of both strains, supplemented with either glucose, sucrose, lactose or maltose showed that production of EPS and cell dry weight was boosted by maltose supplementation. Result: Nostoc sp. N27P72 which was isolated from lime stones was higher, resulting in 9.1 ± 0.05 µg/ml and 1.01 ± 0.06 g/l in EPS and cell dry. The cell cultures tested for their ability to remove Cu(II), Cr(III) and Ni(II) in media culture containing the maltose and without maltose as control culture. Remarkably, we showed that although these elements can be toxic, supplementing the media culture can effectively sequester their toxic effects by increasing the production of EPSs, carbohydrates and total soluble proteins in comparison to control. The crude EPS showed metal adsorption capacity assuming the order Ni(II)> Cu(II)> Cr(III) from metal-binding experiments. Nickel was preferentially biosorbed with a maximal uptake of 188.8 ± 0.14 mg (g cell dry wt) -1 crude EPS. FT-IR spectroscopy revealed treatment with Ni made changes in the functional groups and glycoside linkages in both strains. Results of Gas Chromatography Mass Spectrometry (GC–MS) to determine the biochemical composition of Nostoc sp. N27P72 showed that strong Ni(II) removal capability is suspected to be associated with the high Cyclotrisiloxane and 1,2-Benzenedicarboxylic acid content. Conclusion: The results of these investigates specified that strains Nostoc sp. N27P72 is good candidates for the commercial production of EPS and might be utilized in bioremediation field as an alternative to synthetic and abiotic flocculants.
Integrated Transcriptomic and Metabolomic Analysis of Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV) infected Lymantria dispar in Tree-top Disease
Authors: Li Fengjiao , Wang Yajie , Yu Xiao , Wang Dun 
Published: April 2021

Abstract
The pioneer record described the phenomenon of nucleopolyhedroviruses (NPVs) manipulating host behavior was named as Tree Top Disease or “Wipfelkrankheit” by Hofmann in 1891. Following publics advised multipartite effect during infection progressing that NPVs adjusting manipulated mode to actualize crossing barriers, immune escape and hormone regulation. In this study, the molecular mechanism of Lymantria dispar Multiple embedded Nucleopolyhedrovirus(LdMNPV)-infected was investigated by a comparison of transcriptomic and metabolomic analysis at four selected time points of LdMNPV-infected and healthy Lymantria dispar (Ld) larvae. Among data collecting, the notably up-regulated and down-regulated genes and metabolomics were used for further analysis. Integrative analysis revealed the content changes of caffeine, glutamate and gamma-Aminobutyric acid involved in LdMNPV inducing behavior change, and the alteration of myo-inositol, phosphatidyl-1D-myo-inositol and relevant genes involved in larval extended instar duration and apoptosis avoiding.
Risk Factors of ICU-Acquired Weakness in Critical Ill Patients with ECMO Support: A Retrospective Study
Authors: chen xinyi , lei xiong , xu xin , Huang Man 
Published: April 2021

Abstract
Background Muscle weakness is exceedingly common in critical illness patients and is well described. However, information on the risk factors of muscle weakness in critically ill patients who received extracorporeal membrane oxygenation (ECMO) support are lacking. Our study aims to clarify the risk factors of ICU-acquired weakness (ICU-AW) in ECMO patients to help early recognize potential weakness. Methods We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a muscle strength sum score < 48 out of a maximal score of 60. Baseline characters and therapy details were collected from the case report form and inspection report. Results 63 patients receiving ECMO support were divided to ICU-AW group and no ICU-AW group according to the Medical Research Council (MRC) score when discharged. A total of 50 of the 63 patients were diagnosed with ICU-AW. On logistic regression analysis, the use of adrenaline apparently increased the odds of developing ICU-AW (OR=6.8,95%CI 1.19-38.92, p=0.032), and it was independent of all other established risk factors for ICU-AW. Meanwhile, the occurrence of infection during ECMO support significantly increased the risks of ICU-AW (OR=7.3,95% CI 1.28-41.24, p=0.025) and was independently associated with the outcome of ICU-AW. Other factors such as mechanical ventilation duration, steroid use and neuromuscular blockade did not differ significantly between the groups in our analysis. Conclusion Infection during ECMO support and use of adrenaline were found independently associated with the development of ICU-AW.
Detailed analysis of recovery process of cranial nerve palsy after IMRT-based comprehensive treatment in nasopharyngeal carcinoma
Authors: zang jian , li yan , luo shanquan , wang jianhua , hou bingxin , yao min , zhao lina , shi mei 
Published: April 2021

Abstract
Background

cranial nerve (CN) palsy in nasopharyngeal carcinoma with cancer-related involvement of cranial nerve has been considered as an unfavorable prognostic factor for NPC. We assessed the role of IMRT based treatment modality on the recovery of CN and investigated the prognostic value of CN palsy recovery.
Methods

A total of 115 NPC patients with CN palsy were included in the study. We referred CTCAE version 5.0 to evaluate the grade of CN palsy.
Results

All patients with grade 1 CN palsy recovered completely during the 2 years of follow-up after definite treatment. Most grade 2 palsy could change gradually to grade 1 palsy or complete recovery during two years of follow-up. The 3-year DFS were 84.9% in patients experienced 1 or 2 symptom of CN palsy compared with 60.3% in patients with more than 2 symptoms of CN palsy (HR: 0.25, 95%CI: 0.07–0.89, P = 0.001).
Conclusions

IMRT based comprehensive treatment could effectively promote the recovery of tumor-related CN palsy in locoregionally advanced NPC.
The Determinants of Caregiver use and its Costs for Elderly Inpatients in Korea: A study applying Andersen’s behavioral model of health care utilization and replacement cost method
Authors: Kim Jennifer Ivy , Kim Sukil 
Published: April 2021

Abstract
Objectives: The average annual healthcare expenditure among elderly patients in Korea is increasing rapidly in indirect healthcare sectors, requiring an understanding of factors related to the use of both formal and informal caregivers. This study aims to analyze the factors related to caregiver use and caregiving costs among hospitalized patients due to acute illness or exacerbation of chronic diseases and whether they differ by age group.Methods: A total of 1,550 study participants from the Korea Health Panel Study Data 2017, consisting of 819 elderly inpatients and 731 nonelderly inpatients, were used for the analysis. Costing methods were applied according to the major type of caregiver during hospitalization. Predisposing, enabling, and need factors were considered to determine the possible factors associated with caregiver use. A two-part model was applied to analyze the factors related to care receiving and estimate incremental costs from care after stratifying subjects by age.Results: Elderly inpatients who used tertiary hospitals (OR: 2.44, p-value <0.00), received financial support (OR: 2.70, p-value <0.00), and had disability status (OR: 1.76, p-value <0.05) were more likely to rely on a caregiver, while elderly inpatients living by themselves had a lower probability of using caregivers (OR: 0.48, p-value <0.00). Also, there was a positive association between caregiving costs and the number of chronic diseases among elderly inpatients (β: 0.66, p-value <0.05) with incremental costs of $567.Conclusion: This study presented significant health-related and socio-environmental characteristics to the use of formal and informal caregiving and its related expenditures. Therefore, healthcare management plans that encompass clinical and social levels should be implemented to ease the caregiver burden.Trial registration: Retrospectively registered
Effectiveness of a Standardized Propolis Extract in Non-surgical Periodontal Therapy
Authors: Salvatori Cinzia , Bernardo Marco , Colonna Aristide , Gargari Mario , Galeotti Fabio , Zaccaria Vincenzo , Volpi Nicola 
Published: April 2021

Abstract
Objectives. We determined the polyphenol content in a defined volume of chemically characterized and standardized propolis sample to evaluate its effectiveness in patients with chronic periodontitis.Materials and methods. After having determined the polyphenol content of a given volume of propolis extract and characterized the molecular profile, 150 patients were enrolled, randomly divided into three groups and subjected to three different treatments, Scaling and Root planing (SRP) associated with propolis, SRP with 1% chlorhexidine gel and SRP only. Before the treatments, Full Mouth Plaque Score (FMPS), Pocket Depth at Probing (PPD), Full Mouth Bleeding Score (FMBS), Impaired furcations according to the Hamp Classification, Mobility, Gingival recession and Clinical Attack Level (CAL) were evaluated. Results. A significant reduction of all the studied variables was observed in the three examined groups even if in the group treated with propolis, after 6 weeks, the reduction, and therefore the improvement, was higher than SRP treatment alone and in the presence of 1% chlorhexidine gel. Finally, there were no significant differences in the reduction of PPD and CAL between the groups treated with chlorhexidine and the group treated with SRP alone.Conclusion. Compared to the other two groups, Subjects treated with 10.4 mg propolis showed a significant improvement in all four variables. Clinical relevance. This study shows that propolis could be used as a natural adjuvant in the treatment of periodontal disease.
NRF2-related transcriptomic alterations as a long-term effect of doxorubicin treatment for childhood acute lymphoblastic leukemia
Authors: Totoń-Żurańska Justyna , Sulicka-Grodzicka Joanna , Seweryn Michal , Pitera Ewelina , Kapusta Przemyslaw , Konieczny Paweł , Drabik Leszek , Kołton-Wróż Maria , Chyrchel Bernadeta , Nowak Ewelina , Surdacki Andrzej , Grodzicki Tomasz , Wołkow Pawel 
Published: April 2021

Abstract
The use of doxorubicin is associated with an increased risk of acute and long-term cardiomyopathy. Despite that the number of cancer survivors is growing constantly, little is known about the transcriptional mechanisms which progress in time leading to severe cardiac outcome. It is also unclear whether long-term transcriptomic alterations are related to an acute response to doxorubicin. We have sequenced miRNA from total plasma and extracellular vesicles (EVs) from 66 acute lymphoblastic leukemia (ALL) survivors treated with doxorubicin and 61 healthy controls (254 samples in total). We identified 94 and 33 TFs regulating differentially expressed miRNA in plasma and EVs compartments, respectively. For total plasma we found: HEY1, NRF2, HIF1A, NOTCH1, and for EVs: TGFB, ZEB1, ASCL2, PELP1, SIP1, TWIST1. Analysis of the data from patients with dilated and idiopathic cardiomyopathy revealed similarities with our data from EVs, especially in the activity of TFs related to epithelial-to-mesenchymal transition (EMT). To verify if similarities exist between acute and long-term response to doxorubicin, we performed experiments on cultured as well as we studied the role of NRF2, previously considered as an important player in acute response, in transcriptomic network upon doxorubicin treatment). KEGG analysis of miRNA targets for EVs indicates development of cardiomyopathy, whereas among GO process we found terms related to cardiac septum. In vitro experiments revealed that NRF2 is co-regulated with NOTCH effectors from HEY family, with known role in muscle regeneration. NRF2 and doxorubicin treatment contribute also to the dysregulation of TWIST family, important for the process of EMT.