bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Activity Improves Anxiety and Apathy in Early Parkinson's Disease: A Longitudinal Follow-Up Study
Authors: Ng Samuel Yong-Ern , Chia Nicole Shuang-Yu , Abbas Mirza Masoom , Saffari Ehsan Seyed , Choi Xinyi , Heng Dede Liana , Xu Zheyu , Tay Kay-Yaw , Au Wing-Lok , Tan Eng-King , Tan Louis Chew-Seng 
Published: January 2021

Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study.Background: Prospective studies that examined the association between physical activity and motor and non-motor domains in early PD are lacking.Methods: 121 PD participants were followed-up prospectively to evaluate the association of physical activity with various symptom domains. The Physical Activity Scale for the Elderly (PASE) was used to measure physical activity annually. PD-related symptoms were categorized by motor, non-motor, and quality of life measures. Multivariate regression with gain score analysis was performed to understand the association of baseline PASE scores with the change of each variable at 1-year follow-up.Results: Higher baseline PASE scores (greater activity) were associated with a younger age, lower MDS-UPDRS motor scores, a smaller levodopa equivalent daily dose, better attention and memory scores, and better QoL. Activity scores in early PD declined on follow-up. Multivariate analysis revealed higher baseline physical activity to be associated with decreased anxiety and apathy scores at 1-year follow-up, after adjusting for demographic variables and medications.Conclusion: We demonstrated that higher baseline physical activity was associated with improved anxiety and apathy symptoms in early PD over a 1-year period.
Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation
Authors: Wu Jiamin , Li Yi , Yu Jiayao , Gan Zhending , Wei Wenyao , Wang Chao , Zhang Lili , Wang Tian , Zhong Xiang 
Published: January 2021

Purpose:N6-methyladenosine (m6A) mRNA methylation is affected by dietary factors and associated with lipid metabolism; however, whether the regulatory role of resveratrol in lipid metabolism is involved in m6A mRNA methylation remains unknown. Here, the objective of this study was to investigate the effect of resveratrol on hepatic lipid metabolism and m6A RNA methylation in the liver of mice.Methods: A total of 24 male mice were randomly allocated to LFD (low-fat diet), LFDR (low-fat diet + resveratrol), HFD (high-fat diet), and HFDR (high-fat diet + resveratrol) groups for 12 weeks (n = 6/group). Final body weight of mice was measured before sacrificing. Perirhemtric fat, abdominal and epididymal fat, liver tissues, and serum were collected at sacrifice and analyzed. Briefly, mice phenotype, lipid metabolic index, and m6A modification in the liver were assessed.Results: Compared to the HFD group, dietary resveratrol supplementation reduced the body weight and relative abdominal, epididymal, and perirhemtric fat weight in high-fat-exposed mice; however, resveratrol significantly increased average daily feed intake in mice given HFD. The amounts of serum low-density lipoprotein cholesterol (LDL), liver total cholesterol (TC), and triacylglycerol (TAG) were significantly decreased by resveratrol supplementation. In addition, resveratrol significantly enhanced the levels of peroxisome proliferator-activated receptor alpha (PPARα), peroxisome proliferator-activated receptor beta/delta (PPARβ/δ), cytochrome P450, family 4, subfamily a, polypeptide 10/14 (CYP4A10/14), acyl-CoA oxidase 1 (ACOX1), and fatty acid-binding protein 4 (FABP4) mRNA and inhibited acyl-CoA carboxylase (ACC) mRNA levels in the liver. Furthermore, the resveratrol in HFD increased the transcript levels of methyltransferase like 3 (METTL3), alkB homolog 5 (ALKBH5), fat mass and obesity associated protein (FTO), and YTH domain family 2 (YTHDF2), whereas it decreased the level of YTH domain family 3 (YTHDF3) and m6A abundance in mice liver.Conclusion: The beneficial effect of resveratrol on lipid metabolism disorder under HFD may be due to decrease of m6A RNA methylation and increase of PPARα mRNA, providing mechanistic insights into the function of resveratrol in alleviating the disturbance of lipid metabolism in mice.
Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats
Authors: Feng Xinchi , Wang Kun , Cao Shijie , Ding Liqin , Qiu Feng 
Published: January 2021

Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects. However, as for berberine’s metabolites, especially phase II metabolites, pharmacokinetics and excretion studies were rarely reported. The objective of this study was to thoroughly investigate the pharmacokinetic and excretion profiles of berberine and its nine metabolites, namely, berberrubine (M1), demethyleneberberine (M2), jatrorrhizine (M3), jatrorrhizine-3-O-β-D-glucuronide (M4), jatrorrhizine-3-O-sulfate (M5), thalfendine-10-O-β-D-glucuronide (M6), berberrubine-9-O-β-D-glucuronide (M7), demethyleneberberine-2-O-sulfate (M8) and demethyleneberberine-2-O-β-D-glucuronide (M9) in rats. An accurate and reliable LC-MS/MS method was developed and validated for the determination of berberine and its nine metabolites in rat biosamples. Pharmacokinetic profiles of berberine and its nine metabolites were obtained after a single intravenous administration (4.0 mg/kg) and oral administration (48.2, 120 or 240 mg/kg) of berberine in rats. For excretion study, rats were intragastrically administered a single dose of 48.2 mg/kg berberine. Our results showed that berberine could be metabolized rapidly and all the nine metabolites could be detected in vivo. The absolute bioavailability of berberine was 0.37 ± 0.11%. As for the AUC0–48 h values, phase II metabolites were much higher than those of phase I metabolites, suggesting that phase II metabolites were the major metabolites exist in blood circulation. 18.6% of the berberine was excreted in feces as berberrubine (M1). The total recovery of berberine and its nine metabolites from urine, bile and feces was 41.2%. This is the first systematic study about the pharmacokinetics and excretion of berberine and its nine metabolites, which will be beneficial for both better understanding the clinical effects and further development of berberine.
Efficacy of Sinus Tarsal Approach Compared With Conventional L-Shaped Lateral Approach in the Treatment of Calcaneal Fractures: A Meta-Analysis
Authors: Ma Dongmei , Huang Lei , Liu Bin , Liu Zhigang , Xu Xin , Liu Jianfeng , Chu Tianyue , Pan Liming 
Published: January 2021

Background: This study aims to compare the efficacy of the sinus tarsal approach (STA) with that of the conventional L-shaped lateral approach (CLSLA) in the treatment of calcaneal fractures by meta-analysis.Methods: PubMed, Embase, Web of Science, the Chinese National Knowledge Infrastructure, and China Wanfang database were searched to collect clinical randomized or non-randomized controlled trials of STA and CLSLA in the treatment of calcaneal fractures from January 2010 to May 2020. The data were analyzed by Stata 15.0 software.Results: A total of 12 clinical trials were included, all of which were retrospective studies, including 961 patients. The results showed that when STA was compared with CLSLA, there was no difference in operation time with mean difference (MD) = −5.51 [95% confidence interval (CI): −12.57 to 1.55, P &gt; 0.05], less bleeding during operation with MD = −18.49 (95% CI:−23.79 to −13.18), no difference in Böhler angle after an operation with MD = 0.78 (95% CI: −0.09 to 1.65) and in Gissane angle with MD = −0.07 (95% CI: −1.90 to 1.77), no difference in American Orthopedic Foot and Ankle Society score with MD = 2.16 (95% CI: −1.07 to 5.38), higher-excellent and better rate of Maryland food function with relative ratio = 1.12 (95% CI: 1.04 to 1.20), and lower of incidence of postoperative complications with relative ratio = 0.23 (95% CI: 0.14–0.37).Conclusion: STA was more effective than CLSLA in the treatment of calcaneal fractures. Moreover, STA had advantages in less intraoperative bleeding, higher-excellent and better rate of Maryland foot function, lower incidence of postoperative complications, and higher safety.
Design and Implementation of a Tensile Testing Machine
Authors: Fábián Hunor , Gergely Attila 
Published: January 2021

Abstract
The aim of this paper is to present the design and manufacturing process of a tensile testing machine capable of measuring the tensile strength of polymeric materials. The structure of the instrument is similar to that used in the industry; however, it is budget friendly. The instrument consists of a frame, and two screws which are driven by two stepper motors. An Arduino is used to control the mechanical part of the instrument and to connect it to the software.
Casting Tool Design and Computer-Aided Manufacturing
Authors: Géresi Zoltán Gergő , Gábora András 
Published: January 2021

Abstract
Designing a casting tool and choosing materials technology parameters calls for special requirements both for workpiece and tool side. After designing the technological steps and procedures I select the cutting tools. Industrial developments take priority in cloud system engineering. I used this system in the casting tool manufacturing process. It is not easy to make a comprehensive and detailed design following technological steps. The allowances and joints were made on the M2L CNC milling machine. The CAM program was made with EdgeCam software. Defining the casting parameters accurately is still a challenge, but in our major it is not the most important. For the future we are planning a most complicated casting tool.
Design of Electron Tube and Semiconductor-Based and Voltage Stabilised Amplifier Circuits
Authors: Hrámcov István , Erdei Timotei István , Décsei Roland , Husi Géza 
Published: January 2021

Abstract
In this project, an electron tube circuit consisting of a voltage stabiliser, preamplifier, and final stage amplifier circuit was designed. One of the main aims was to reuse as many components and materials as possible, thereby decreasing the project’s ecological footprint. The result is a hybrid electron tube amplifier. The function of the circuits was subsequently measured and analysed using various tests.
V4 Security and Defense Policy – National and Allied Challenges in Member States
Authors: Hronyecz Erika 
Published: January 2021

Abstract
Making the common European security and defense policy more effective starts at state level. It is of paramount importance that the member states of the respective federations are able to demonstrate modern forces with a high level of compatibility and qualification and also that the use of these national forces, at allied level, should be possible without major obstacles. In this publication, the author presents the main historical points of the defense policy of the Visegrad Co-operation (V4) countries, and in this context the steps and efforts required of the force in order to respond to new types of security challenge.
THE RESEARCH OF THE THERMOLYSIS PRODUCTS OF CESIUM TUNGSTOPHOSPHATES
Authors: Moroz Y. , Lozynskyy M. , Lopanov A. , Chebyshev K. , Burkhovetsky V. 
Published: January 2021

The article deals with the synthesis, study of thermal decomposition and identification of the thermolysis products of cesium tungstophosphates that are promising compounds in the field of materials science, catalysis and other fields of science and technology.
Compounds with the Keggin anion structure are synthesized from aqueous solutions: Cs3[PW12O40] ∙ 9H2O; Cs5Na2[PW11O39(H2O)] ∙ 5H2O and Cs5[PW11O39Ni0,5Cu0,5(H2O)] ∙ 4H2O. The processes of their thermal decomposition are investigated and some regularities of their thermolysis are established. Thermolysis products are identified: Cs3PW12O40, phases with the structure of pyrochlore and hexagonal tungsten bronze of the composition Cs10/13Na4/13P2/13W22/13O6 and Cs10/13P2/13Ni1/13Cu1/13W22/13O6. The unit cell parameters of the phase with the pyrochlore structure are determined. Research results confirm that phosphorus, nickel and copper ions are included in the structure of pyrochlore and hexagonal tungsten bronze. Phases similar to this chemical composition are not previously known in the literature. The studied tungstophosphates and their thermolysis products are promising compounds for obtaining heterogeneous catalysts for the oxidation of organic compounds and selective sorbents. The research results can be useful for predicting the thermal properties and phase composition of thermolysis products of similar polyoxometallates in order to obtain new compounds with the structure of pyrochlore and hexagonal tungsten bronze, as well as composite materials based on them.
PRINCIPLES OF ALGORITHMIC FORMATION IN DESIGNING RESIDENTIAL UNITS FOR TEMPORARY ARCTIC SETTLEMENT
Authors: Zhukovskaya D. , Ivchenko A. 
Published: January 2021

One of the special aspects of the Arctic region is the predominance of the rotational settlement. This article studies the types and principles of the formation of settlement systems in the Arctic zones as well as the factors that form the subject-spatial decisions in them. A distinctive characteristic of this form is the "sprouting" of domiciled settlements from temporary settlements as well as the simultaneous appearance of such a phenomenon as "dead cities". This influenced many life areas of the local population: from urban planning plans and housing construction technologies to the peculiarities of formation of subcultures and regional identity. By the example of subject-spatial complexes of temporary mobile settlements in the Arctic region, it is proposed to consider the time cycle as an object of design and its impact on the socio-cultural aspect of the life of the foreign-born population. A design concept for the self-organization of the system in the life cycle was proposed. Methods of spatial modeling were considered on the example of an engineering system for object modeling, where the feature is the presence of unified modular elements with an original mechanical detachable interface.
The study used the methods of historical, cultural, and systems analysis, a systematic approach to design, scenario modeling, conceptual forecasting based on synergetic theory (theory of self-organization of systems), structural and spatial modeling.
VERTICAL GARDENING IN THE URBAN ENVIRONMENT AS A METHOD OF REDUCING ECOLOGICAL STRESS
Authors: Kostina E. , Mironenko O. , Milavski S. 
Published: January 2021

In the context of the constant development of society, the modern environment is very important for a modern person. A city is a space that should provide a comfortable life. Also, it is a place where a society develops, communicates and interacts. In an urbanized city, building system is becoming increasingly impact, as the population is constantly increases. The construction of new residential areas, public buildings, industrial enterprises requires more and more “green” areas to clear. This negatively affects the comfortable living of a person in the city.
In this article such gardening method in the structure of a modern city as vertical gardening, as an alternative to horizontal gardening was studied. Different variations of vertical gardening as well as international examples were discussed.
Based on the study carried out, the conclusion on a positive effect of vertical gardening on the physical and psychological health of a person, on environment improvement, generally, as well as on increasing the aesthetic attraction of urban spaces.
El exante y expost del pensamiento crítico de la Chakana Pregunta
Authors: Bocanegra Vilcamango Beder 
Published: January 2021

El desarrollo de la investigación cualitativa sobre el entorno de los conceptos de diversos modos de enseñar y aprender ha permitido identificar hallazgos relacionados con la naturaleza de los conceptos de estrategia didáctica. Las motivaciones y las perspectivas de los conceptos
que tipifican el sentido ideal de las estrategias no se corresponden con la naturaleza del proceso de enseñanza-aprendizaje, ya que el arraigo de la epistemología es muy frágil y el contexto educativo no se ha considerado. El objetivo de estudio es caracterizar los propósitos de los organizadores visuales más recurrentes, con la finalidad de definir el exante y expost de la Chakana Pregunta, relacionada con el pensamiento crítico. En el desarrollo curricular del curso Desarrollo Humano se recogieron siete conceptos de estrategia didáctica como parte de los trabajos académicos. Los estudiantes plantearon varias perspectivas en cada concepto, que han sido motivo de análisis y contextualización. El estudio se basa en 44 estudiantes de pregrado, correspondientes al segundo ciclo de formación pedagógica. El hallazgo que trasciende sobre los conceptos establecidos, cronológicamente, desde la aparición del cuadro sinóptico hasta el cuadro CQA, no se refiere a los procesos educativos.
Por lo tanto, los conceptos no son pertinentes, porque los propósitos fueron ajenos a la tarea educativa. Con el análisis de los conceptos, el diagnóstico inicial caracterizó la fragilidad de las prácticas didácticas al no focalizar el desarrollo del pensamiento crítico. Al término del ciclo académico se operacionalizó con el concepto y se consideraron tres elementos: la relación enseñanza-aprendizaje, el aporte de la epistemología y el contexto educativo.
COMPARATIVE ANALYSIS OF POPULAR PLATFORMS FOR LEARNING MANAGEMENT SYSTEMS
Authors: Коваленко С.А. , Барабанов А.В. , Гребенникова Н.И. , Малиновкин В.А. 
Published: January 2021

В настоящий момент система онлайн-образования принимает новые масштабы. Потребность в платформе, в которой будет гармонично сочетаться современный функционал и простота пользования, всё больше и больше увеличивается. Использование новейших технических разработок позволяет создавать электронные платформы для организации качественного онлайн-обучения. Представлен обзор платформ, а именно: «Moodle», «iSpring Learn» и «Google Calssroom». Рассматриваемые сервисы имеют большую целевую аудиторию и высокий спрос в сфере онлайн-образования. С помощью них можно осуществлять как очное, так и заочное обучение, хранение информации курса, тестов и лекций, а также производить контроль за прохождением обучения и вести отчётность. Были рассмотрены преимущества и недостатки каждого сервиса. Сравнение платформ производится по ряду характеристик, а именно: удобство интерфейса, мобильность системы (развертывание системы без привлечения специалистов), наличие встроенного редактора курса, наличие видеоконференции, доступность основного функционала, наличие дополнительного функционала, поддержка различного рода файловых расширений, гибкость системы, наличие мобильных приложений, денежные затраты при использовании платформы. Эти аспекты выступают основными при выборе платформы, так как они являются ключевыми при использовании сервисов онлайн-обучения
At the moment, the online education system is taking on new dimensions. The need for a platform that will harmoniously combine modern functionality and ease of use is increasing. Creating electronic platforms using the latest technical developments allows you to organize high-quality online education. This article provides an overview of the platforms, namely: "Moodle", "iSpring Learn" and "Google Calssroom". These services have a large target audience and high demand in the field of online education. They can be used for both full-time and part-time training, storing course information, tests, and lectures, as well as monitoring training progress and maintaining reports. We considered the advantages and disadvantages of each service. We compare the platforms by a number of characteristics, namely: usability, mobility of the system (deployment system without the involvement of specialists), the presence of the built-in editor of the course, the availability of video conferencing, the availability of core functionality, additional functionality, support of various kinds of file extensions, the flexibility of the system, the availability of mobile applications, costs when using the platform. These aspects are the main ones when choosing a platform, as they are key when using online learning services
STOCHASTIC DECODING OF LINEAR BLOCK CODES USING CHECK MATRIX
Authors: Башкиров А.В. , Свиридова И.В. , Хорошайлова М.В. , Свиридова О.В. 
Published: January 2021

Для итеративного декодирования на графах используется новый альтернативный подход - это стохастическое декодирование. Возможность стохастического декодирования была недавно предложена для декодирования LDPC-кодов. Эта статья расширяет применение стохастического подхода для декодирования линейных блочных кодов с помощью проверочных матриц (PCM), таких как коды Боуза - Чоудхури - Хоквингема (BCH), коды Рида - Соломона (RS) и блочные турбокоды на основе компонентов кодов BCH. Показано, как стохастический подход способен генерировать информацию мягкого выхода для итеративного декодирования с мягким входом и мягким выходом Soft - Input Soft - Output (SISO). Описывается структура стохастических переменных узлов высокой степени, используемых в кодах с помощью проверочных матриц PCM. Результаты моделирования для кода BCH (128, 120), кода RS (31, 25) и RS (63, 55) и турбокода блока BCH (256, 121) и (1024, 676) демонстрируют эффективность декодирования при закрытии к итеративному декодеру SISO с реализацией с плавающей запятой. Эти результаты показывают производительность декодирования, близкую к адаптивному алгоритму распространения доверия и/или турбо-ориентированному адаптированному алгоритму распространения доверия
Stochastic decoding capability has recently been proposed for decoding LDPC codes. This paper expands on the application of the stochastic approach to decoding linear block codes using parity check matrices (PCMs) such as Bose-Chowdhury-Hawkingham (BCH) codes, Reed-Solomon (RS) codes, and BCH component-based block turbo codes. We show how the stochastic approach is able to generate soft-output information for iterative decoding with soft-input and soft-output Soft-Input Soft-Output (SISO). We describe the structure of high degree stochastic node variables used in codes using PCM parity check matrices. Simulation results for BCH code (128, 120), RS code (31, 25) and RS (63, 55), and BCH block turbo code (256, 121) and (1024, 676) demonstrate the decoding efficiency on close to SISO iterative decoder with floating point implementation. These results show decoding performance close to the adaptive trust propagation algorithm and / or turbo-oriented adapted trust propagation algorithm