bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Computational Study of Hyaluronidase
Interactions with Glycosaminoglycans and their Ligands
Authors: Maksimenko Alexander V. , Sakharova Yuliya S. , Beabealashvilli Robert S. 
Published: December 2021

:
Covalent conjugation of hyaluronidase with copolymeric glycosaminoglycans (GAG,
heparin and dermatan sulfate) considerably inactivates the enzyme, while conjugation with
polymeric GAG (chondroitin sulfate and hyaluronan) improves its stability. These effects are
associated with structural differences of these GAG caused by С-5 epimerization of glucuronic and
iduronic acid residues and different effects of (α[1 – 4] and α[1 – 3] relative to β[1 – 4] and β[1 – 3])
glycosidic bonds. Pronounced effects of galactose C-4 epimers (in comparison with glucose) and
disaccharide mixture (lactose, cellobiose, maltose) on endoglycosidase activity of hyaluronidase
emphasize the importance of its diversified multi-contact microenvironment. For a better
understanding of the mechanisms regulating hyaluronidase activity, molecular docking and
molecular dynamics were chosen. Stabilization effect of chondroitin ligands on heat inactivation of
hyaluronidase was demonstrated. An increase in denaturation temperature by 10-15oC hampers
blocking of the active site entrance and prevents the enzyme inactivation. Enzyme-GAG
interactions were examined by molecular docking with molecular dynamic elaboration. Gradual
chemical modification of hyaluronidase was based on the calculated sequence of preferential
binding of GAG. Theoretically, covalent binding of chondroitin sulfate trimers at cs7 or cs7, cs1 and
cs5 on the enzyme surface provides complete protection against heparin inhibition. Computational
investigation of hyaluronidase microenvironment and interactions which limit the enzyme activity
allows identification of the best GAG regulators of hyaluronidase endoglycosidase activity and their
experimental verification.
Neurodegeneration and Glial Activation Related CSF Biomarker as the Diagnosis
of Alzheimer’s Disease: A Systematic Review and an Updated Meta-
analysis
Authors: Hao Yuehan , Liu Xu , Zhu Ruixia 
Published: December 2021

Objective:
Recently, neuron specific enolase (NSE), Visinin-like protein-1 (VLP-1), neurogranin
(Ng), and YKL-40 have been identified as candidates for neuronal degeneration and glial
activation biomarkers. Therefore, we perform a comprehensive meta-analysis to assess the diagnostic
value of CSF NSE, VLP-1, Ng and YKL-40 in Alzheimer’s disease (AD).

Methods:
We searched Pubmed, MEDLINE, EMBASE databases for research about the levels of
CSF NSE, VLP-1, Ng and YKL-40 in AD patients compared with controls or other dementia diseases
until Dec 2020.

Results :
The present meta-analysis contained a total of 51 studies comprising 6248 patients with
dementia disorders and 3861 controls. Among them, there were 3262 patients with AD, 2456 patients
with mild cognitive impairment (MCI), 173 patients with vascular dementia (VaD), 221 patients
with frontotemporal dementia (FTD), and 136 with Lewy bodies dementia (DLB). Our study
demonstrated that CSF NSE, VLP-1, Ng and YKL-40 levels were increased in AD as compared to
healthy controls. We also observed that the CSF NSE level was higher in AD than VaD, suggesting
CSF NSE might act as a key role in distinguishing between AD and VaD. Interestingly, there
was a higher VLP-1 expression in AD, and a lower expression in DLB patients. Moreover, we
found the CSF Ng level was increased in AD than MCI, implying CSF Ng might be a biomarker
for identifying the progression of AD. Additionally, a significantly higher CSF YKL-40 level was
detected not only in AD, but also in FTD, DLB, VaD, signifying YKL-40 was not sensitive in the
diagnosis of AD.

Conclusion:
Our study confirmed that CSF levels of NSE, VLP-1, and Ng could be valuable biomarkers
for identifying patients who are more susceptible to AD and distinguishing AD from other
neurodegenerative dementia disorders.
Impact of COVID-19 Lockdown on Glycemic Control in Patients with
Type 2 Diabetes Mellitus in Dubai
Authors: Makki Ibtehal , Alnoon Nouf , Rahmani Najma , Almulla Jawaher , Alamiri Asma , Alfalasi Aisha , Zidan Marwan 
Published: December 2021

Objective:
The objective of this study is to evaluate the impact of the COVID-19 lockdown
on glycemic control and accompanying laboratory parameters in patients with type 2 Diabetes
Mellitus.

Methods:
This study is a retrospective cohort study that was done on a multicenter level. It was
conducted during the lockdown in 341 individuals. HbA1c was tested to measure glycemic control
immediately before and after the lockdown period that lasted for 13 weeks.

Results:
The primary outcome was the improvement of mean HbA1C after 13 weeks of lockdown
compared to the pre-lockdown HbA1C. It was found that the mean HbA1C improved from 7.5±1.5
to 7.3±1.5 with a p-value of 0.001.

Conclusion:
Our study showed that patients with type 2 diabetes mellitus exhibited an improvement
in their glycemic control after the period of lockdown.
A Copeptin as a Predictor Marker for Insulin Resistance Among Women
with Polycystic Ovary Syndrome
Authors: Ali Alaa Ibrahim , Hassan Wassan Nori Mohammed , Alrawi Sumaya 
Published: December 2021

Background:
A polycystic ovarian syndrome (PCOS) is a common endocrine syndrome
in which women have a wide range of clinical presentations; insulin resistance was linked to its
pathogenesis.

Objective:
We aimed to investigate the copeptin role as a predictive marker of insulin resistance
among PCOS women.

Material and Methods:
In University Hospital, we included 280 women, with 140 of them being
healthy controls. 140 out of 280 cases of PCOS subdivided into two groups depending on the insulin
resistance; group 1 with homeostasis model assessment for the insulin resistance < 2.5. Group
2 with homeostasis model assessment for the insulin resistance >2.5. The evaluation of body mass
index and blood pressure for all besides the blood sampling for estimation of a follicular stimulating
hormone, luteinizing hormone, prolactin, estradiol, sex hormone-binding globulin, total testosterone,
fasting insulin dehydroepiandrosterone sulfate, C-reactive protein, plasma glucose, free androgen
index, and plasma copeptin using the Copeptin-Human EIA Kit besides the transvaginal ultrasound
for ovarian assessment.

Results:
When compared to other groups, PCOS women with positive insulin resistance >2.5 had a
significantly higher plasma copeptin level. The ROC curve calculated a 1.94 pmol/L; plasma
copeptin cutoff value for detecting the insulin resistance in PCOS with 88 % sensitivity value and
36 % specificity, AUC was 0.88.

Conclusion:
The significant positive relationship between serum copeptin and insulin resistance
with high sensitivity implies its usefulness as a marker of insulin resistance among PCOS patients
with a high prediction of its complication.
Identifying Insomnia From Social Media Posts: Psycholinguistic Analyses of User Tweets
Authors: Sakib Ahmed Shahriar , Mukta Md Saddam Hossain , Huda Fariha Rowshan , Islam A K M Najmul , Islam Tohedul , Ali Mohammed Eunus 
Published: December 2021

Background
Many people suffer from insomnia, a sleep disorder characterized by difficulty falling and staying asleep during the night. As social media have become a ubiquitous platform to share users’ thoughts, opinions, activities, and preferences with their friends and acquaintances, the shared content across these platforms can be used to diagnose different health problems, including insomnia. Only a few recent studies have examined the prediction of insomnia from Twitter data, and we found research gaps in predicting insomnia from word usage patterns and correlations between users’ insomnia and their Big 5 personality traits as derived from social media interactions.

Objective
The purpose of this study is to build an insomnia prediction model from users’ psycholinguistic patterns, including the elements of word usage, semantics, and their Big 5 personality traits as derived from tweets.

Methods
In this paper, we exploited both psycholinguistic and personality traits derived from tweets to identify insomnia patients. First, we built psycholinguistic profiles of the users from their word choices and the semantic relationships between the words of their tweets. We then determined the relationship between a users’ personality traits and insomnia. Finally, we built a double-weighted ensemble classification model to predict insomnia from both psycholinguistic and personality traits as derived from user tweets.

Results
Our classification model showed strong prediction potential (78.8%) to predict insomnia from tweets. As insomniacs are generally ill-tempered and feel more stress and mental exhaustion, we observed significant correlations of certain word usage patterns among them. They tend to use negative words (eg, “no,” “not,” “never”). Some people frequently use swear words (eg, “damn,” “piss,” “fuck”) with strong temperament. They also use anxious (eg, “worried,” “fearful,” “nervous”) and sad (eg, “crying,” “grief,” “sad”) words in their tweets. We also found that the users with high neuroticism and conscientiousness scores for the Big 5 personality traits likely have strong correlations with insomnia. Additionally, we observed that users with high conscientiousness scores have strong correlations with insomnia patterns, while negative correlation between extraversion and insomnia was also found.

Conclusions
Our model can help predict insomnia from users’ social media interactions. Thus, incorporating our model into a software system can help family members detect insomnia problems in individuals before they become worse. The software system can also help doctors to diagnose possible insomnia in patients.
Modelo de Personalidad Positiva: Diferencias entre Población Clínica y Población General
Authors: Eidman Leandro , De la Iglesia Guadalupe 
Published: December 2021

El objetivo de este trabajo fue estudiar la estructura factorial de un modelo de rasgos positivos de la personalidad en una muestra de población clínica, analizar diferencias en los rasgos positivos en comparación con una de población general y estudiar las asociaciones entre los rasgos positivos y la sintomatología psicológica en la muestra de población clínica. La muestra clínica estaba compuesta por 185 sujetos residentes en argentina cuyo promedio de edad era de 30.19 años (DE = 11.59, 59.5% mujeres, 40.5% varones). La muestra de población general estaba compuesta por 203 sujetos residentes en argentina cuya edad promedio era de 31.63 años (DE = 10.22, 64.5% mujeres, 35.5% hombres. Los resultados de lo estudios psicométricos de la medida de rasgos positivos indicaron el buen funcionamiento de la medida en población. Se encontró que los participantes pertenecientes a población clínica presentaron menor presencia de rasgos positivos de la personalidad en comparación con los individuos de población general y que los rasgos positivos de la personalidad se asociaron de forma negativa con la presencia de la mayoría de los síntomas psicopatológicos.
Autorretrato Infamiliar | Non-familiar self-portrait
Authors: Martiól de Souza Dariane 
Published: December 2021

Este ensaio é parte de um projeto fotográfico em desenvolvimento onde registro o corpo da minha mae junto ao meu dentro do espaço doméstico, tematizando uma relação conflituosa. ORCIDhttps://orcid.org/0000-0002-7526-337X
Apresentação - Sua voz em nossas cabeças: 20 anos sem Sebald | His voice in our heads: 20 years without Sebald
Authors: Malcher Beatriz , Tomm Davi Alexandre 
Published: December 2021

Texto de apresentação do dossiê temático "20 anos sem Sebald" ORCIDhttp://orcid.org/0000-0003-4077-3860https://orcid.org/0000-0001-5713-0701
Comparison of abnormalities in the sequence of growth stages in the skeletal maturity index vs cervical vertebral maturation:
Authors: Chung David D. , Ghanouni Sepand 
Published: December 2021

ABSTRACT

Objectives
To evaluate the frequency of abnormal progression that could ultimately affect the reliability of the skeletal maturity index (SMI) and the cervical vertebral maturation (CVM) method that are most commonly used analyses for skeletal age assessment.

Materials and Methods
A retrospective design was used to compare 299 hand-wrist radiographs with 299 lateral skull radiographs regarding the number of abnormalities in the proposed sequence of maturation in the SMI and CVM methods.

Results
A significantly greater number of abnormalities occurred in the sequence of CVM progression compared with SMI (P &lt; .001). Sex and age did not have an effect.

Conclusions
Skeletal age assessment based on SMI is more accurate than CVM regarding the progressive sequence of stages.
SISTEM AGRIBISNIS JAGUNG DI KECAMATAN ADILUWIH KABUPATEN PRINGSEWU
Authors: Virgiana Sita , Arifin Bustanul , Suryani Ani 
Published: December 2021

This research aimed to know the procurement of corn production facilities, farm performance, corn marketing, supporting institutions and index of agribusiness system. This research was conducted in Adiluwih Subdistrict of Pringsewu Regency. The data were collected on March - April 2018 by survey method. The result of this research showed that the procurement of production facilities that did not accord to the criteria were price and quantity. The average income from the corn agribusiness system was Rp9,973,527.8/ha and it was profitable because the R/C ratio was higher than one. Marketing of agribusiness systems was inefficient because its market was oligopsonic structure, farmers did not have the power to determine the price of corn and the profit margin ratio did not spread evenly. The supporting institutions in Adiluwih Subdistrict were farmer groups, extension agents, financial institutions, government policies, transportation and markets. All supporting institutions were available but not fully utilized by farmers. The supporting institutions which related to the agribusiness system were farmer groups, government policies and extension institutions. The agribusiness index in terms of production facilities has been good, while the agribusiness index in terms of farming and marketing performance has not been good. In general, the corn agribusiness index has notbeen good. Key words: agribusiness index, agribusiness system, corn
ANALISIS SISTEM AGRIBISNIS TERNAK KAMBING (Studi Kasus pada Usaha Peternakan Prima Aqiqah di Kota Bandar Lampung)
Authors: Guna Megi Adi , Lestari Dyah Aring Hepiana , Suryani Ani 
Published: December 2021

This research aims to analyze procurement system of production facilities that are appropriate to six preciseness (on time, place, quality, quantity, type, and price), income from the goat livestock business, added value of goat processed products, the marketing channels of goat livestock, and supporting servicesfor goat farming. This research uses a case study method carried out at Prima Aqiqah Farm in Bandar Lampung City. This location is chosen purposively as consideration that Prima Aqiqah Farm is a goat breeding business that processes goat products. Data were collected in April—May 2017 and analyzed usinga qualitative and quantitative desctiptive analysis. The results of this research shows that the procurement of production facilities for the goat farm business at Prima Aqiqah Farm has fulfilled the six preciseness. The goat of Prima Aqiqah Farm is profitable and feasible because R/C value ≥ 1. Therefore, processed products at Prima Aqiqah Farm have positive added value. The marketing channel for goat livestock products has two marketing channels, namely direct marketing channels to consumers and indirect. While processed productsonly have one marketing channel which is a direct marketing channel to consumers. Supporting service institutions that support the business activities of goats are financial institutions, transportation facilities, and information and communication technologies that provide benefits for Prima Aqiqah Farm.Key words : agribusiness system, aqiqah, goat
ANALISIS EFISIENSI USAHATANI JAGUNG ANGGOTA DAN NON-ANGGOTA KELOMPOK TANI DI KECAMATAN MARGA TIGA KABUPATEN LAMPUNG TIMUR
Authors: Santiasih Ni Nyoman Tri , Lestari Dyah Aring Hepiana , Suryani Ani 
Published: December 2021

This research aims to analyze the level of technical efficiency, technical inefficiency factors, and economic efficiency of corn farming of members and nonmembers of farmer groups. This research was conducted in the Gedung Wani and Negeri Katon Villages of Marga Tiga District, East Lampung. Respondent farmers were determined intentionally with a simple random sampling. This research use a survey method and the data were collected in February-March 2019. Technical efficiency, technical inefficiency factors, and economic efficiency were analyzed using the Stochastic Frontier 4.1. The results showed that corn farming in Marga Tiga District was technically efficient, with an efficiency of 0.95. The number of family members can increase technical inefficiency, age and experience can reduce technical inefficiency, while education and farmer groups membership do not affect technical inefficiency. Corn farming in Marga Tiga District was also economically efficient with an efficiency level 0.89 for members of farmer groups and 0.90 for non-members of farmer groups.Key words: corn farming, efficiency, farmer groups
ANALISIS RANTAI PASOK DAN NILAI TAMBAH AGROINDUSTRI KELANTING DI DESA GANTIMULYO KECAMATAN PEKALONGAN LAMPUNG TIMUR
Authors: Aprilia, Muhammad Nanda , Affandi Muhammad Irfan , Kasymir Eka 
Published: December 2021

This study aims to analyze supply chain performanc, and added value in kelanting agroindustry in Gantimulyo Village. This research was conducted at six kelanting agroindustries in Gantimulyo Village, Pekalongan District, East Lampung Regency. Data collection was conducted in February 2019. Data were analyzed using qualitative and quantitative descriptive analysis. Performance measurements were made by comparing indicators on FoodSCOR Card indicators. The calculation of added value used Hayami added value method. The results showed the flow pattern of supply chain started from farmers and agent as the main suppliers of raw materials. The perfomance of kelanting agroindustri showed that the average indicators were good based on indicators comparison of FoodSCOR card. The added value shows a positive value, meaning that kelanting agroindustry is feasible to be developed. Key words: added value, kelanting, supply chain.
PENDAPATAN DAN RISIKO USAHATANI CABAI DI KECAMATAN SUMBEREJO KABUPATEN TANGGAMUS
Authors: Mala Nurul , Prasmatiwi Fembriarti Erry , Sayekti Wuryaningsih Dwi 
Published: December 2021

This research aims to find out the comparison of income and the risk of chili pepper (Capsicum annum L.) farming and cayenne pepper (Capsicum Frutescens L.) farming. The study was conducted in three villages at Sumberejo Sub-district of Tanggamus Regency. This research used a survey method and respondents in this research were 30 chili pepper farmers and 30 cayenne pepper farmers. The data analysis used is farm income analysis and risk analysis uses coefficient of variation. To find out the comparison of income and risk of farming was independent sample t-test. The results showed that the income of chili pepper farming was higher than that of cayenne pepper farming with the income of IDR119,047,409.08 per hectare and IDR49,579,450.49 per hectare. There is no significant difference between production risk and income from chili pepper and cayenne pepper farming. The price risk of chili pepper farming is higher than that of cayenne pepper.Key words: Chili farming, income, risk
HUBUNGAN MOTIVASI, KEMAMPUAN, KEDISIPLINAN, DAN KEPUASAN KERJA DENGAN KINERJA MANDOR DI PT GREAT GIANT PINEAPPLE DEPARTEMEN PG 2 LAMPUNG TENGAH
Authors: Husna Arnum Wahida Banati , Sayekti Wuryaningsih Dwi , Nugraha Adia 
Published: December 2021

The purposes of this study are to find out the level of motivation, ability, discipline, and job satisfaction, and their relationship with the performance of the foremen at PT Great Giant Pineapple Department of PG 2. This research uses a census method with 67 foremen and 19 section heads as respondents. Data collection was conducted in August to October 2019. Primary data in this study are motivation, ability, discipline, and job satisfaction, while secondary data used are foreman performance. The data are analyzed using Pearson Product Moment correlation analysis method. The results showed that motivation, discipline, and job satisfaction of the foremen are in the very high category, while the foreman's ability is in the high category. Motivation, ability, and discipline have a positive and significant relationship with the performance of the foremen, whereas job satisfaction does not relate to the performance of the foremen. Key words: ability, discipline, job satisfaction, motivation
ANALISIS MANAJEMEN RISIKO DAN STRATEGI PEMASARAN AGROINDUSTRI KOPI BUBUK (Studi kasus Agroindustri Kopi Bubuk Cap Gunung Betung)
Authors: Maharani Asila Jelita , Haryono Dwi , Nugraha Adia 
Published: December 2021

This study aims to analyze the production performance, risk management and marketing strategies agroindustry Gunung Betung coffee powder in Bandar Lampung City. This research use a case study method in Kopi Bubuk Cap Gunung Betung agroindustry. Data collection was conducted on Desember 2019-Januari 2020. This study uses qualitative and quantitative descriptive method. Production performance was analyze using productivity and capacity. Risk agroindustry use ISO 31000 management standard. Strategies marketing use SWOT analyses. Alternative strategies formulated by SWOT matrix. The shows that performance of Kopi Bubuk Cap Gunung Betung Agroindustry in Bandar Lampung city is consider good, process risk, human resource risk, and incidental risks faced are low, the marketing strategies is increase production volume by maintaining and improving product quality, optimizing the use of business locations close to suppliers to increase production volume, utilizing high consumer demand by providing quality products to obtain high profits. Keywords: agroindustry, ground coffee, marketing strategies, production performance, risk management.
Perbedaan Latihan Passing Target dan Rangkaian Latihan Passing terhadap Kemampuan Passing Bawah Atlet Bolavoli SMAN 8 Padang
Authors: Bule Jefri , _ Donie 
Published: December 2021

Masalah Penelitianini rendahnya kemampuan passing bawah atlet bolavoli SMAN 8 Padang. Tujuan penelitian ini untuk mengetahui perbedaan pengaruh latihan passing target dan rangkaian latihan passing bawah terhadap kemampuan passing bawah atlet bolavoli SMAN 8 Padang.Penelitian ini, metoda latihan passing bawahmenggunakanlatihantarget dan rangkaian latihan passing bawah dengan latihan terprogram. Jenis penelitian inieksperimen semu, dilakukan pada atlet bolavoli SMAN 8 Padang. Populasi penelitian seluruh atlet bolavoli SMAN 8 Padang. sampel penelitian iniatlet putra bolavoli SMAN 8 Padang berjumlah 16 orang. Teknik pemilihan sampel penelitianinipurposive sampling. Instrumen test yang digunakan dalam penelitian ini adalah Repeated Volleys Test, Validitas 0,80 Reliabilitas 0,87teknik analisis penelitian ini menggunakan uji-t. Hasil penelitian ini adalah thitung (3,57) > ttabel (1,761) passing bawah target dan thitung (3,69) > ttabel (1,761) rangkaian latihan passing bawah dari kedua latihan itu terdapat hasil peningkatan antara pretest dan posttest. Perbandingan kedua bentuk latihan mendapatkan perbedaan nilai sehinggah memberikan kesimpulan perbedaan signifikan antara bentuk latihan passing target dengan rangkaian latihan passing bawah terhadapkemampuan passing bawah atlet bolavoli SMAN 8 Padang. Artinya bentuk latihan passing target lebih berpengaruh dibandingkan dengan rangkaian latihan.