bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of spatial patellofemoral alignment using novel three-dimensional measurements based on weight-bearing cone-beam CT
Authors: Chen Yurou , Yu Fan , Rong Fanzhuang , Lv Furong , Lv Fajin , Li Jia 
Published: January 2025

Abstract
Objectives
To propose a reliable and standard 3D assessment method to analyze the effect of weight-bearing (WB) status on the location of patella and clarify the diagnostic performance of 3D parameters for recurrent patellar dislocation (RPD) in WB and non-weight-bearing (NWB) conditions.

Methods
Sixty-five knees of RPD patients and 99 knees of controls were included. Eight landmarks, two lines and a coordinate system were defined on 3D bone models of knees based on weight-bearing CT and non-weight-bearing CT. The shift and tilt of patella in three orthogonal axes (Xshift, Yshift, Zshift, Xtilt, Ytilt, Ztilt) were evaluated.

Results
Xshift and Yshift were significantly higher, Zshift, Xtilt and Ytilt were significantly lower in WB condition than NWB condition (p < 0.001, p < 0.001, p = 0.001, p = 0.002, p = 0.010). In both WB and NWB conditions, Xshift, Yshift and Ztilt were significantly higher, and Xtilt was significantly lower in the RPD group than the control group (WB/NWB: p < 0.001/p = 0.002, p < 0.001/p = 0.001, p < 0.001/p < 0.001, p < 0.001/p = 0.009). In WB condition, Zshift and Ytilt were significantly higher in the RPD group than the control group (p = 0.011, p < 0.001). Ztilt had the best diagnostic performance for RPD in both WB and NWB conditions, with AUC of 0.887 (95% CI: 0.828, 0.946) and 0.885 (95% CI: 0.822, 0.947), respectively.

Conclusions
The 3D measurement method reliably and comprehensively reflected the relative spatial position relationship of the patellofemoral joint. It can be applied to the 3D preoperative planning of patellofemoral procedures. In addition, patellofemoral evaluation under the WB condition was essential to detect subtle underlying risk factors for RPD, with axial lateral patellar tilt being the best predictor.

Critical relevance statement
This 3D measurement method under weight-bearing conditions contributes to comprehensively describing the relative spatial position of the patellofemoral joint in a standardized way and can be applied to preoperative evaluation for recurrent patellar dislocation.

Key Points

Patellofemoral alignment is a 3D problem, and the accuracy of 2D parameters has been questioned.

3D measurement was reliable and comprehensively reflected relative spatial relationships of the patellofemoral joint.

3D measurements under weight-bearing condition help preoperative evaluation for RPD.

Graphical Abstract
Barriers and facilitators to the implementation and adoption of computerised clinical decision support systems: an umbrella review protocol
Authors: Böhm-Hustede Anna Katharina , Lubasch Johanna Sophie , Hoogestraat Anna Thalea , Buhr Eike , Wulff Antje 
Published: January 2025

Abstract
Background
The implementation of computerised clinical decision support systems has the potential to enhance healthcare by improving patient safety, practitioner performance, and patient outcomes. Notwithstanding the numerous advantages, the uptake of clinical decision support systems remains constrained, thereby impeding the full realisation of their potential. To ensure the effective and successful implementation of these systems, it is essential to identify and analyse the reasons for their low uptake and adoption. This protocol outlines an umbrella review, which will synthesise the findings of existing literature reviews to generate a comprehensive overview of the barriers and facilitators to the implementation and adoption of decision support systems across healthcare settings.

Methods
This umbrella review protocol was developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. Searches for eligible articles will be conducted in four electronic bibliographic databases, including PubMed/MEDLINE, IEEE Xplore, Scopus, and Web of Science. Obtained results will be independently screened by four reviewers based on pre-defined eligibility criteria. The risk of bias will be assessed for all eligible articles. Data on barriers and facilitators to the implementation and adoption of clinical decision support systems will be extracted, summarised, and further categorised into themes that aim to describe the originating environment or concept of the respective factor. The frequency of all identified barriers and facilitators within the group of included reviews will be determined in order to establish a prioritisation of the factors.

Discussion
This umbrella review protocol presents a methodology for the systematic synthesis of barriers and facilitators to the implementation and adoption of clinical decision support systems across healthcare settings. The umbrella review will enable the development of novel implementation and adoption strategies that reinforce the identified facilitators and circumvent barriers, thereby promoting the use-oriented evaluation and effective utilisation of clinical decision support systems.

Systematic review registration
PROSPERO CRD42024507614
Association between axial elongation and corneal topography in children undergoing orthokeratology with different back optic zone diameters
Authors: Tan Qi , Kojima Randy , Cho Pauline , Vincent Stephen J. 
Published: January 2025

Abstract
Purpose
To explore the associations between myopia defocus dosage (MDD), aberration coefficients (primary spherical aberration and coma), and axial elongation in children undergoing orthokeratology (ortho-k) with back optic zone diameters (BOZD) of 5 mm and 6 mm over 2 years.

Methods
Data from 80 participants from two ortho-k studies were analyzed: 22 and 58 children wore lenses with 5-mm and 6-mm BOZD, respectively. Four MDD metrics were calculated from corneal topography data over a 5-mm pupil for the 1-month and 24-month visits: the circumferential, flat, steep, and volumetric MDD. Corneal primary spherical aberration and comatic aberrations were also extracted from topography data over a 5-mm pupil. Linear mixed modelling was performed to explore the associations between the MDD, corneal aberrations, and axial elongation over 2 years, while controlling for confounding factors (e.g., baseline age and sex).

Results
Participants in the 5-mm BOZD group displayed less axial elongation than the 6-mm BOZD group over 2 years (0.15 ± 0.21 mm vs. 0.35 ± 0.21 mm, P < 0.001). A greater volumetric MDD was observed in the 5-mm BOZD group compared with the 6-mm BOZD group at the 1- and 24-month visits (both P < 0.001). No significant differences were observed between the two groups for the other MDD metrics or corneal aberration coefficients (all P > 0.05). Less axial elongation was associated with a greater volumetric MDD at the 1- and 24-month visits (both β = –0.01, P < 0.001 and P = 0.001), but not with any other MDD metrics or corneal aberrations (all P > 0.05).

Conclusions
The volumetric MDD over a 5-mm pupil after 1 month of ortho-k lens wear was associated with axial elongation after 24 months, and may be a useful predictor of future axial elongation in children undergoing ortho-k.
CEO political orientation and loan contract
Authors: Chung Chune Young , Choi Changhwan , Nhan Do Thi Thanh 
Published: January 2025

AbstractBanks rely on soft information when assessing loan applications, making it crucial to evaluate the trustworthiness of potential borrowers in order to set loan conditions, even in a legal environment where contractual rights are straightforwardly enforced. Given the common belief that certain personality traits—such as trustworthiness, reliability, loyalty, thriftiness, and stinginess—are more often linked to conservatives (Republicans) than to liberals (Democrats), we investigate whether companies with conservative chief executive officers (CEOs) secure more advantageous loan terms compared to others. Our findings indicate that firms with conservative CEOs are able to negotiate bank loans with lower interest spreads and upfront fees. While we do not observe a direct impact of CEO overconfidence on loan pricing, we reveal that the combined influence of CEO conservatism and overconfidence contributes to our primary findings. Additionally, we discovered that conservative CEOs tend to receive more favorable non-price conditions (fewer covenants) and are less inclined to offer collateral.
Semi-standardized evaluation of extraprostatic extension and seminal vesicle invasion with [18F]PSMA-1007 PET/CT: a comparison to MRI using histopathology as reference
Authors: Hvittfeldt Erland , Hedeer Fredrik , Thimansson Erik , Sandeman Kevin , Minarik David , Ingvar Jacob , Bjartell Anders , Trägårdh Elin 
Published: January 2025

Abstract
Background
Positron emission tomography/computed tomography (PET/CT) with prostate specific membrane antigen ligands (PSMA) is established for use in primary staging of prostate cancer to screen for metastases. It has also shown promise in local tumor staging, including detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI). Previous studies have shown high heterogeneity in methods and results. Our aim was to compare [18F]PSMA-1007 PET/CT to magnetic resonance imaging (MRI) in evaluation of EPE and SVI, building on a previously described method for standardized evaluation. We retrospectively included 124 patients who had undergone MRI, PSMA PET/CT and prostatectomy. PSMA PET/CT images were evaluated by two nuclear medicine physicians. Using a standardized method, they measured length of capsular contact (LCC) and assessed EPE and SVI visually with the use of 5-point Likert scales. A radiologist evaluated MRI images using criteria based on Prostate Imaging–Reporting and Data System version and incorporating LCC measurement and Likert scales. We evaluated diagnostic performance with histopathology as reference, and the interrater reliability of the PET evaluations.

Results
The sensitivity and specificity for detecting EPE with the quantitative LCC method for PSMA PET/CT was 0.46/0.91, for the visual method 0.28/0.82 and for the combination of the two 0.54/0.76. AUC in ROC analysis for the LCC method was 0.70. For MRI the sensitivity and specificity were 0.80/0.64. For SVI, PET/CT and MRI had sensitivity and specificity of 0.14/1.0 and 0.50/0.92 respectively. The intraclass correlation coefficient for the PET LCC measurement was 0.68, the kappa values for the visual Likert scales for PET were 0.53 for EPE and 0.63 for SVI.

Conclusions
In this study, we attempted to standardize quantitative and qualitative PSMA PET/CT evaluation of EPE and SVI and compare the method with MRI. MRI had a higher sensitivity for EPE while PSMA had a higher specificity. For SVI, both methods had high specificity. The interrater reliability for the PSMA PET/CT evaluations was moderate to substantial.
Central Downregulation of S-Resistin Alleviates Inflammation in EWAT and Liver and Prevents Adipocyte Hypertrophy
Authors: Rodríguez María , Moltó Eduardo , Serrano Rosario , Diaz-Rullo Jorge , Parralejo Iván , Muñoz Diego , Andreu Rosa María , Seco Jennifer , Gallardo Nilda , Andrés Antonio , Arribas Carmen , Pintado Cristina 
Published: January 2025

Abstract
The hypothalamus integrates peripheral signals and modulates food intake and energy expenditure by regulating the metabolic function of peripheral tissues, including the liver and adipose tissue. In a previous study, we demonstrated that s-resistin, an intracellular resistin isoform highly expressed in the hypothalamus and upregulated during aging, is important in the central control of energy homeostasis, affecting mainly the peripheral response to insulin by still unknown mechanisms. Herein, using an intracerebroventricular injection of a specific lentiviral RNAi against s-resistin, we assessed, in the Wistar rat, the effects of central s-resistin downregulation on the expression and phosphorylation levels of intermediates involved in insulin signaling and the inflammatory response in epididymal white adipose tissue (eWAT) and liver. Additionally, we studied the imbalance of eWAT hypertrophy/hyperplasia remodeling. Our results indicate that central downregulation of s-resistin regulates insulin signaling cascade in a tissue-specific manner, reduces the inflammatory status both in the liver and eWAT, and prevents eWAT hypertrophy. Taken together, our results highlight the pivotal role of central s-resistin in maintaining metabolic homeostasis in AT and the liver. This suggests a direct association between its function and the modulation of the inflammatory response in these tissues.
1 joule arbitrary pulse shape hybrid laser source
Authors: Ovcharenko B. , Kamynin V. , Bagdasarov V. , Dolmatov T. , Trikshev A. , Ponarina M. , Tsvetkov V. , Garnov S. 
Published: January 2025

A hybrid laser source with a profiled laser pulse shape is presented. It is designed with a fiber pulse shaping system and a two-stage solid-state amplifier based on two gain modules with pulsed transverse diode pumping. The ability to control the pulse shape of the hybrid laser source pulse is demonstrated, and rectangular and stepped pulse shapes with a radiation wavelength of 1064.15 nm, duration of 20 ns, repetition rate of 2 Hz, and output energy of 1 J are obtained. The resulting shapes are achieved by controlling the temporal shape of the pulses of the master oscillator to compensate for the effect of gain saturation in solid-state amplifiers. The dynamics of the pulse shape evolution as a function of the electrical pump energy in the gain modules is traced.
Refined phase-matching predictions for AgGa1-xInxS2 mixed chalcopyrite crystals
Authors: Kato Kiyoshi , Miyata Kentaro , Petrov Valentin 
Published: January 2025

This paper presents the Sellmeier equations for AgInS2, combined with recently derived equations for AgGaS2, to provide the accurate phase-matching conditions of AgGa1−xInxS2 for nonlinear three-wave mixing across the 0.6164–10.5910 µm range. A new set of these index formulas successfully reproduces the measured 90° phase-matching conditions of AgGa0.46In0.54S2 (x=0.54) for frequency-doubling the emission of Nd:YAG laser-pumped optical parametric oscillators (OPOs) at 2.7780 and 8.6880 µm as well as for frequency-mixing the signal and idler outputs of such an OPO at 1.1940 and 9.7893 µm, respectively.
The association between helicobacter pylori infection and Triglyceride-Glucose (TyG) index in US adults: A retrospective cross-sectional study
Authors: Fu Wei , Zhao Junlong , Chen GuoBin , Lyu Linya , Ding Yao , Xu Liang-Bi 
Published: January 2025

Background
The Triglyceride-glucose (TyG) index is a marker for insulin resistance and metabolic syndrome, while Helicobacter pylori is linked to gastrointestinal diseases and may affect metabolic risks. This study examined the association between the TyG index and H. pylori infection in adults.

Methods
Data from 3797 participants in the NHANES 1999–2000 cycle were analyzed. The relationship between the TyG index and H. pylori infection was assessed using multivariate logistic regression and a two-piecewise logistic model to explore non-linear effects. Subgroup analyses were conducted based on age, sex, glucose levels, BMI, and CKD.

Results
A linear association between the TyG index and H. pylori infection was found. Subgroup analyses revealed significant interactions with a few variables.

Conclusions
This study indicates a linear relationship between the TyG index and H. pylori infection, suggesting metabolic influences on H. pylori infection and potential for targeted interventions in at-risk groups.
Disparities in time to treatment initiation of invasive lung cancer among Black and White patients in Tennessee
Authors: Mamudu Lohuwa , Sulley Saanie , Atandoh Paul H. , Reyes Joanne L. , Bashar Raquibul A. K. M. , Whiteside Martin , McEligot Archana J. , Mamudu Hadii M. , Williams Faustine 
Published: January 2025

Background
Early initiation of treatment for lung cancer has been shown to improve patient survival. The present study investigates disparities in time to treatment initiation of invasive lung cancer within and between Black and White patients in Tennessee.

Methods
A population-based registry data of 42,970 individuals (Black = 4,480 and White = 38,490) diagnosed with invasive lung cancer obtained from the Tennessee Cancer Registry, 2005–2015, was analyzed. We conducted bivariate ANOVA tests to examine the difference in time to treatment initiation among independent factors, and multivariable Cox proportional hazard models to identify independent factors that influence median time to treatment initiation after diagnosis.

Results
When considering the estimate of the proportion of time to treatment initiation based on the combined influence of all independent factors (sex, age, race, marital, county of residence, health insurance, cancer stage, and surgical treatment), Black patients were generally more at risk of delayed treatment compared to Whites. Black patients aged <45 years (adjusted hazard ratio [aHR] = 1.40; 95% confidence interval [CI] = 1.01–1.94) and married White patients (aHR = 1.13; 95% CI = 1.07–1.18) had the highest increased risk of late treatment among their respective racial subgroups. In the general sample, patients with private health insurance had (aHR = 1.08; 95% CI = 1.01–1.16) higher risk of late treatment beyond 2.7 weeks compared to self-pay/uninsured patients. This was consistent among both Black and White subsamples. Patients with localized and regional lung cancer stages had a decreased risk of delayed treatment compared to those diagnosed at the distant stage among both Black and White patients.

Conclusions
Black patients were often at greater risk of late initiation of treatment for invasive lung cancer in Tennessee. Additional research is needed to understand factors influencing time to treatment initiation for Black patients in Tennessee. Further, cancer care resources are needed in Black communities to ensure timely treatment of invasive lung cancer, reduce disparities, and promote equitable care for all cancer patients.
Association between early life second-hand smoke exposure on child sleep and psychoactive substance use on adult sleep patterns in an urban informal settlement in Uganda
Authors: Wafula Solomon T. , Namakula Lydia N. , Isunju John B. , Mugambe Richard K. , Ssekamatte Tonny , Musoke David , Wanyenze Rhoda K. 
Published: January 2025

Background
Psychoactive substance use in adults and second-hand smoke (SHS) exposure among children are leading contributors to sleeping problems. Despite this, there is limited data on how these exposures influence sleep patterns in informal settings. Our study assessed the associations between substance use, SHS exposure and sleep disturbances among adults and children in an urban informal settlement in Uganda.

Methods
We conducted a cross-sectional study in an urban informal settlement in Kampala, Uganda. Data was collected on self-reported sleep problems among adults including sleep duration, insomnia and sleep dissatisfaction, as well, as sleep-disordered breathing (SDB) in children. We evaluated children’s early-life SHS exposure and psychoactive substance use in adults using questionnaires. We modelled the associations between the exposures and sleep problems in adults and children using modified Poisson regression.

Results
Data were collected from 284 adults, who also reported on their children’s sleep experience. Among adults, 59.2% reported insufficient sleep (less than 7 hours), 34.9% experienced insomnia, and 28.3% were dissatisfied with their sleep patterns. Active smoking was associated with insomnia (Prevalence Ratio (PR) = 2.74, 95% Confidence Interval (CI): 1.14–6.59), and alcohol use was associated with sleep dissatisfaction (PR = 1.81, 95% CI 1.23–2.69). In children, 40.0% (88/220) exhibited SDB problems. Those exposed to SHS either during pregnancy or within six months post-birth had a higher risk of SDB than unexposed children (PR = 1.78, 95% CI 1.21–2.61). The risk was also elevated for children exposed to SHS during both periods (PR = 1.48, 95% CI 1.02–2.13).

Conclusions
Our findings suggest that smoking was associated with insomnia and alcohol with sleep dissatisfaction among adults. Early-life SHS exposure was associated with an increased risk of SDB in children. These results emphasize the need to support ongoing public health initiatives and maintain a smoke-free environment, particularly for children in their early life.
Association between serum vitamin D and severe headache or migraine: A population-based analysis
Authors: Hao Shunfa , Qian Renyi , Chen Yiru , Liu Jingfang , Xu Xiaoyan , Guan Yunxiang 
Published: January 2025

Background
Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or inconclusive results. Therefore, further research is needed to better understand the relationship between vitamin D and migraine headaches.

Methods
We selected 9142 participants from the 2001–2004 National Health and Nutrition Examination Survey (NHANES). In our study, the term "serum vitamin D" refers to the concentration of 25OHD2 + 25OHD3 (nmol/L) in the blood. Migraine was assessed based on self-reports in the miscellaneous pain section of the NHANES questionnaire. Associations between vitamin D and the risk of migraine were examined using multiple logistic regression, smoothed curve fitting, and stratified analyses.

Results
In our study, 20.53% of the participants suffered from migraine. The prevalence of migraine was higher in those with lower serum vitamin D levels. Participants in the highest quartile of serum vitamin D levels were found to have a 16% lower prevalence than those in the lowest quartile in the fully adjusted model (OR = 0.84, 95% CI 0.71–0.99). This result was supported by stratified analysis and smoothed curve fitting.

Conclusion
Our study showed a significant negative correlation between serum vitamin D levels and the prevalence of migraine in American adults.