bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Soekapdjo Soeharjoto , Aryani Tribudhi Debbie , Delfina Harahap Cicely , Hariyanti Dini , Tajib Erny 
Published: September 2021

Micro and small businesses in Indonesia survived during the economic crisis until the Covid-19 pandemic arrived. This situation, brings major change in people's consumption behavior that results in decreased income. Aims of this activity is to provide knowledge and insight to increase micro and small businesses income in new normal era at Cordova Bina Amanah Entrepreneurship School. Participants are given materials of market structure, marketing media and marketing media costs, using educational and training methods. This activity, can increase average knowledge and insights of the material to 79,67% . This activity should be carried out continuously, added with diverse materials related to digital technology, whether online or offline. Participants as businessmen needs to apply promotion with digital technology, build personal branding, innovation and product diversification, and registered their businesses at Cooperative Service for micro, small, and medium enterprises.
PENDAMPINGAN MANAJEMEN PRODUK UMKM “TAHU BAROKAH” MADIUN
Authors: Wardoyo Putro Prima Utama , Sulistiyowati Liliek Nur , Asmike Metik 
Published: September 2021

Perkembangan dunia modern menciptakan tekanan yang besar terhadap pelaku usaha dewasa ini, tak terkecuali Usaha Mikro Kecil Menengah (UMKM). Perubahan teknologi, budaya, dan arus informasi yang cepat menciptakan kompetisi pasar yang begitu hebat. Hal ini cukup berdampak terhadap daya saing UMKM yang memiliki keterbatasan dari segi teknologi, informasi, dan akses ke dunia luar. Salah satu UMKM yang merasakan dampak ini adalah UMKM Tahu Barokah yang berada di Kota Madiun. Keterbatasan pengetahun terhadap perkembangan dunia modern membuat UMKM yang memproduksi olahan tahu ini semakin sulit bernafas ditengah persaingan yang begitu ketat. Pelaksanaan pengabdian masyarakat ini menyasar pelaku usaha Tahu Barokah di Kota Madiun. Dalam pelaksanaan kegiatan ini, difokuskan pada manajemen produk yang meliputi: pengemasan produk yang bisa meningkatkan daya Tarik produk, manajemen pengolahan yang bisa menciptakan efisiensi, pemasaran produk untuk memperluas jangkauan pemasaran, serta administrasi pembukuan usaha. Kegiatan ini diharapkan bisa meningkatkan daya saing UMKM Tahu Barokah ditengah ketatnya persaingan produk serupa. Kegiatan yang dilakukan selama kurang lebih dua bulan ini, mendapat respon yang baik dari pelaku usaha dan masyarakat sekitar.
Penyuluhan Dan Pelatihan Invisible & Visible Knowledge Profiling Untuk Meningkatkan Kompetensi Pada SMA Negeri 3 Semarang
Authors: Gamayanto Indra , Sukamto Titien Suhartini , Sani Ramadhan Rakhmat , Wibowo Sasono , Winarno Sri , Rohmani Asih 
Published: September 2021

AbstrakPendidikan memiliki arti menggabungkan antara pengetahuan dan pengalaman untuk menghasilkan inovasi yang bermanfaat bagi umat manusia. Keduanya saling terhubung satu sama lain dan tidak boleh dipisahkan. Oleh sebab itu, menggabungkan antara pengetahuan dan pengalaman adalah hal mutlak yang seharusnya diterapkan dalam semua lini pendidikan agar siap dalam menghadapi globalisasi dengan level tertinggi. Definisi kesempurnaan adalah menggabungkan antara pengetahuan dan pengalaman sehingga menghasilkan hal-hal inovatif yang bermanfaat dan memberikan kontribusi positif terhadap hidup orang banyak. Artikel ini merupakan penyuluhan dan pelatihan invisible & visible knowledge profiling yang merupakan dua hal penting yang harus dapat dikembangkan di dalam pendidikan dan dunia kerja. Lebih jauh lagi, artikel ini merupakan pengembangan dari artikel sebelumnya yaitu pelatihan dan implementasi social media profiling. Pengabdian masyarakat yang kami lakukan haruslah berkelanjutan dan terus dikembangkan hingga mencapai tingkat kualitas tertinggi dalam pengetahuan, inilah prinsip yang terdapat pada invisible & visible knowledge profiling. Hasil dari artikel ini adalah bagaimana car akita meningkatkan kinerja sumber daya manusia yang terdapat di dalam dunia pendidikan, profil lengkap kemampuan dan sumber daya manusia yang ada, klasifikasi dan tahapan apa saja yang seharusnya dapat dilakukan. Konsep dalam artikel ini menggabungkan dengan tiga metode yaitu 3SDP-mendukung komunitas belajar aktif, merancang peluang kepemimpinan, menghasilkan sumber daya pendidikan (yang berasal dari Harvard University), Johari window dan E=KM.C2. Kata kunci: Pendidikan, Invisible-visible knowledge, Inovasi, Profiling, Sumber Daya Manusia
The Challenge of Home Allergen Re-introductions Using the Ladder Approach in Children With Non-IgE Mediated Gastrointestinal Food Allergy
Authors: Meyer Rosan , De Koker Claire , Dziubak Robert , Godwin Heather , Reeve Kate , Chebar-Lozinsky Adriana , Foong Ru-Xin , Skrapac Ana-Kristina , Ellmer Marlene , Shah Neil 
Published: September 2021

Background: Oral food challenges remain the most reliable method for allergy confirmation. Although consensus guidelines have been published to unify Immunoglobulin E (IgE)-mediated challenges, this does not exist for non-IgE mediated gastrointestinal allergies outside of Food Protein Induced Enterocolitis Syndrome. We therefore set out to establish the use of home introduction protocols (HIP) for confirmation of food allergy for milk, soya, egg and wheat using a ladder approach in children with non-IgE mediated allergy.Materials and Methods: Patients with suspected non-IgE mediated gastrointestinal allergies (0–16 years) were recruited following symptom improvement on an elimination diet. All children had skin prick or specific IgE tests to rule out IgE-mediated allergies prior to suggestion the HIP. Number of trials and outcome was documented. HIPs were developed using a published ladder approach for cow's milk as baseline and final dose was calculated based on guidelines for food protein induced enterocolitis syndrome and portions for age from the National Diet and Nutrition Survey. First foods were baked/highly processed and every 4th day patients moved to a more unprocessed/unheated food.Results: From 131 recruited patients, 117 (89.3%) followed the HIP for food allergens. No adverse events were documented. In more than 50% of cases one attempt at the HIP was sufficient to establish allergy status, but many required 2–5 attempts before the outcome was clear. About half of the children were fully tolerant to foods they initially eliminated: 36, 26 and 30% were partially tolerant to milk, soya, and egg and only 15% achieved partial tolerance to wheat. Wheat was the allergen introduced earliest, followed by soya, cow's milk and egg.Conclusions: This study indicates that home HIPs are safe in non-IgE mediated gastrointestinal food allergy and that the ladder approach may be useful in re-introducing allergens in children at home with non-IgE mediated gastrointestinal allergies. From this study we can also conclude that tolerance to processed/baked allergens was observed in many children. Further studies should be performed on the HIP and ideally reintroduction should occur pre-defined time intervals.
Magnetic Properties of Electrodeposited Cobalt-Platinum (CoPt) and Cobalt-Platinum-Phosphide (CoPtP) Thin Films
Authors: Park D.-Y. , Myung N. V. 
Published: September 2021

CoPt and CoPtP thin films were synthesized using direct current (DC) aqueous electrodeposition from weak alkaline solutions. The basic plating solutions of binary CoPt thin films consisted of cobalt pyrophosphate [Co2P2O7] and chloroplatinic acid [H2PtCl6]. Various amounts of sodium hypophosphite [NaH2PO2] was added to deposit ternary CoPtP thin films. The film composition was adjusted by varying the several electrodeposition parameters including electrolyte composition, solution pH, and current density and correlated to their microstructure and magnetic property (i.e. coercivity and squareness). For the binary CoPt thin films, the maximum coercivities [in-plane coercivity (Hc,//) = ∼1,600 Oe, and perpendicular coercivity (Hc,⊥) = ∼2,500 Oe] were obtained from electrolytes containing 0.01 M H2PtCl6 + 0.04 M Co2P2O7 at current density (CD) of 7.5 mA cm−2. In the case of ternary CoPtP electrodeposits, the maximum coercivities (Hc,// = ∼2,600 Oe, and Hc,⊥ = ∼3,800 Oe) were achieved from baths containing 0.015 M H2PtCl6, 0.07 M Co2P2O7, 0.8 M NaH2PO2 at CD of 7.5 mA cm−2 and solution pH 9. It was suggested that microstructure and magnetic properties are affected not only by the type of substrate but also by chemical compositions and electrodeposition conditions.
Usefulness of Diastolic Function Score as a Predictor of Long-Term Prognosis in Patients With Acute Myocardial Infarction
Authors: Bae SungA , Yoon Hyun Ju , Kim Kye Hun , Kim Hyung Yoon , Park Hyukjin , Cho Jae Yeong , Kim Min Chul , Kim Yongcheol , Ahn Youngkeun , Cho Jeong Gwan , Jeong Myung Ho 
Published: September 2021

Background: Left ventricular diastolic function (LVDF) evaluation using a combination of several echocardiographic parameters is an important predictor of adverse events in patients with acute myocardial infarction (AMI). To date, the clinical impact of each individual LVDF marker is well-known, but the clinical significance of the sum of the abnormal diastolic function markers and the long-term clinical outcome are not well-known. This study aimed to investigate the usefulness of LVDF score in predicting clinical outcomes of patients with AMI.Methods: LVDF scores were measured in a 2,030 patients with AMI who underwent successful percutaneous coronary intervention from 2012 to 2015. Four LVDF parameters (septal e′ ≥ 7 cm/s, septal E/e′ ≤ 15, TR velocity ≤ 2.8 m/s, and LAVI ≤ 34 ml/m2) were used for LVDF scoring. The presence of each abnormal LVDF parameter was scored as 1, and the total LVDF score ranged from 0 to 4. Mortality and hospitalization due to heart failure (HHF) in relation to LVDF score were evaluated. To compare the predictive ability of LVDF scores and left ventricular ejection fraction (LVEF) for mortality and HHF, receiver operating characteristic (ROC) curve and landmark analyses were performed.Results: Over the 3-year clinical follow-up, all-cause mortality occurred in 278 patients (13.7%), while 91 patients (4.5%) developed HHF. All-cause mortality and HHF significantly increased as LVDF scores increased (all-cause mortality–LVDF score 0: 2.3%, score 1: 8.8%, score 2: 16.7%, score 3: 31.8%, and score 4: 44.5%, p &lt; 0.001; HHF–LVDF score 0: 0.6%, score 1: 1.8%, score 2: 6.3%, score 3: 10.3%, and score 4: 18.2%, p &lt; 0.001). In multivariate analysis, a higher LVDF score was associated with significantly higher adjusted hazard ratios for all-cause mortality and HHF. In landmark analysis, LVDF score was a better predictor of long-term mortality than LVEF (area under the ROC curve: 0.739 vs. 0.640, p &lt; 0.001).Conclusion: The present study demonstrated that LVDF score was a significant predictor of mortality and HHF in patients with AMI. LVDF scores are useful for risk stratification of patients with AMI; therefore, careful monitoring and management should be performed for patients with AMI with higher LVDF scores.
Characteristics Analysis of Small Insulated Vans Based on Thermoelectric Cooling
Authors: Yuan Xiao-Hong , Qin Chuang-Hui , Wang Yi-Ping , Liu Xun 
Published: September 2021

In cold chain logistics, refrigerated trucks are used for long-distance transportation across cities, and insulated trucks are used for short-distance delivery within cities. However, the small insulated vans for short-distance transportation like delivering home in urban have heat leakage and no pre-cooling, the transportation time of traffic congestion becomes longer, resulting in poor insulation effect. So, to achieve stable temperature control is difficult, it leads to a big fluctuation in the temperature of the cargo. The thermoelectric cooling technology has the unique advantages of compact structure, flexible layout, no refrigerant, and environmental friendliness, which is very suitable for controlling the temperature of the small insulated vans. In the paper, relationship among COP, working power, and working current of the designed thermoelectric cooler (TEC) is investigated first. And then the best working state of the TEC is obtained. Next, set hot and cold dual temperature zones to ensure the effective use of energy based on thermoelectric cooling characteristics, arranged the cooling device in the insulated van, and revealed the changes in the temperature of the compartment and the cargo through the actual vehicle test. Compared the thermal insulation effect of the compartment with or without thermoelectric cooling technology through CFD. According to the simulation results, the cargo temperature of the insulated van fluctuates between 4 and 6°C within 2.5 h of actual delivery in urban, the insulated van using thermoelectric cooling technology can make the temperature of the cargo fluctuate within 1.5°C. The above proved the good insulated effect of the thermoelectric cooling insulated vans. Finally, the influence of the working time of the thermoelectric refrigeration system on the temperature control effect is also studied. The research results have a certain guiding significance for the application of thermoelectric cooling technology in insulated vans.
Thymic T-Cell Production Is Associated With Changes in the Gut Microbiota in Young Chicks
Authors: Cheng Jiaheng , Yuan Yushan , Zhao Fang , Chen Jianwei , Chen Peng , Li Ying , Yan Xia , Luo Chenglong , Shu Dingming , Qu Hao , Ji Jian 
Published: September 2021

Increasing studies show that gut microbiota play a central role in immunity, although the impact of the microbiota on mediation of thymic T cells throughout life is not well understood. Chickens have been shown to be a valuable model for studying basic immunology. Here, we show that changes in the gut microbiota are associated with the development of thymic T cells in young chickens. Our results showed that T-cell numbers in newborn chicks sharply increased from day 0 and peaked at day 49. Interestingly, the α-diversity score pattern of change in gut microbiota also increased after day 0 and continued to increase until day 49. We found that early antibiotic treatment resulted in a dramatic reduction in gut alpha diversity: principal component analysis (PCA) showed that antibiotic treatment resulted in a different cluster from the controls on days 9 and 49. In the antibiotic-treated chickens, we identified eight significantly different (p &lt; 0.05) microbes at the phylum level and 14 significantly different (p &lt; 0.05) microbes at the genus level, compared with the controls. Importantly, we found that antibiotic treatment led to a decreased percentage and number of T cells in the thymus when measured at days 9 and 49, as evaluated by flow cytometry. Collectively, our data suggest that intestinal microbiota may be involved in the regulation of T cells in birds, presenting the possibility that interventions that actively modify the gut microbiota in early life may accelerate the maturation of humoral immunity, with resulting anti-inflammatory effects against different pathogens.
Raman Spectra of Bulk and Few-Layer GeSe From First-Principles Calculations
Authors: Zhao Yi-Feng , Guan Zhao , Zhong Ni , Yue Fang-Yu , Xiang Ping-Hua , Duan Chun-Gang 
Published: September 2021

Raman spectra play a significant role in the study of polar materials. Herein, we report the influence of strain and interlayer shift on vibration responses in bulk and few-layer ferrovalley material GeSe in different polarization states (ferroelectric/FE and antiferroelectric/AFE) based on density functional theory and density functional perturbation theory calculations. We find Ag1 mode shifts by about 10 cm−1 from monolayer to bilayer and trilayer due to the interlayer coupling. The Ag3 mode on behalf of FE mode is observed that is consistent with the experiments in bulk and few-layer GeSe. Meanwhile, in our calculations, with the transition between AFE and FE state in the bilayer and trilayer, the Raman frequency of Ag2 and Ag3 mode decrease obviously whereas that of Ag1 mode increases. Interestingly, the Raman peaks shifted a lot due to the strain effect. We expect these variations in the Raman spectroscopy can be employed to identify the status of GeSe films, e.g., the AFE or FE state, and the number of layers in experiments.
Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice
Authors: Basgen John M. , Wong Jenny S. , Ray Justina , Nicholas Susanne B. , Campbell Kirk N. 
Published: September 2021

Background: Podocyte foot process effacement is a key histologic finding in proteinuric kidney disease. We previously showed that 3-week old CD2AP-deficient mice have significant proteinuria, glomerular hypertrophy and mesangial expansion. The goal of this study is to use morphometry to establish the temporal sequence of podocyte foot process effacement, glomerular volume expansion and albuminuria in Cd2ap−/− mice by measuring these parameters at the 2-week time point.Methods: Wild-type mice age 14 ± 1 days with the Cd2ap gene (WT, N = 5) and mice deficient for Cd2ap (Cd2ap KO, N = 5) were generated. Kidneys were harvested and fixed in 2.5% glutaraldehyde and processed for examination by light and electron microscopy. An average of 415.2 (range 268–716) grid points were counted for all the glomeruli, and quantification of glomerular volume from each kidney. Urine was collected the day prior to sacrifice for urine albumin-to-creatinine ratio (ACR) measurements.Results: There was no difference in albuminuria [median (range) mg/g] between WT [212.2 (177.6–388.4) mg/g] vs. Cd2ap KO mice [203.3 (164.7–910.2) mg/g], P = 0.89; or glomerular volume 68,307[10,931] vs. 66,844[13,022] μm3, p = 0.92. The volume densities of glomerular components of the podocyte, capillary lumen and mesangium were not different for the two groups, P = 0.14, 0.14 and 0.17 respectively. However, foot process width was increased in Cd2ap KO 1128[286] vs. WT [374 ± 42] nm, P = 0.02.Conclusion: Here we show that while 2-week old WT and Cd2ap KO mice have similar levels of albuminuria, glomerular and mesangial volume, Cd2ap KO mice have more extensive podocyte foot process effacement. The data suggests that podocyte injury is the initiating event leading to mesangial expansion and albuminuria in this model.
Consecutive Serial Non-Contrast CT Scan-Based Deep Learning Model Facilitates the Prediction of Tumor Invasiveness of Ground-Glass Nodules
Authors: Xu Yao , Li Yu , Yin Hongkun , Tang Wen , Fan Guohua 
Published: September 2021

IntroductionTumors are continuously evolving biological systems which can be monitored by medical imaging. Previous studies only focus on single timepoint images, whether the performance could be further improved by using serial noncontrast CT imaging obtained during nodule follow-up management remains unclear. In this study, we evaluated DL model for predicting tumor invasiveness of GGNs through analyzing time series CT imagesMethodsA total of 168 pathologically confirmed GGN cases (48 noninvasive lesions and 120 invasive lesions) were retrospectively collected and randomly assigned to the development dataset (n = 123) and independent testing dataset (n = 45). All patients underwent consecutive noncontrast CT examinations, and the baseline CT and 3-month follow-up CT images were collected. The gross region of interest (ROI) patches containing only tumor region and the full ROI patches including both tumor and peritumor regions were cropped from CT images. A baseline model was built on the image features and demographic features. Four DL models were proposed: two single-DL model using gross ROI (model 1) or full ROI patches (model 3) from baseline CT images, and two serial-DL models using gross ROI (model 2) or full ROI patches (model 4) from consecutive CT images (baseline scan and 3-month follow-up scan). In addition, a combined model integrating serial full ROI patches and clinical information was also constructed. The performance of these predictive models was assessed with respect to discrimination and clinical usefulness.ResultsThe area under the curve (AUC) of the baseline model, models 1, 2, 3, and 4 were 0.562 [(95% confidence interval (C)], 0.406~0.710), 0.693 (95% CI, 0.538–0.822), 0.787 (95% CI, 0.639–0.895), 0.727 (95% CI, 0.573–0.849), and 0.811 (95% CI, 0.667–0.912) in the independent testing dataset, respectively. The results indicated that the peritumor region had potential to contribute to tumor invasiveness prediction, and the model performance was further improved by integrating imaging scans at multiple timepoints. Furthermore, the combined model showed best discrimination ability, with AUC, sensitivity, specificity, and accuracy achieving 0.831 (95% CI, 0.690–0.926), 86.7%, 73.3%, and 82.2%, respectively.ConclusionThe DL model integrating full ROIs from serial CT images shows improved predictive performance in differentiating noninvasive from invasive GGNs than the model using only baseline CT images, which could benefit the clinical management of GGNs.
Treosulfan-Based Conditioning Regimen Prior to Allogeneic Stem Cell Transplantation: Long-Term Results From a Phase 2 Clinical Trial
Authors: Lazzari Lorenzo , Ruggeri Annalisa , Lupo Stanghellini Maria Teresa , Mastaglio Sara , Messina Carlo , Giglio Fabio , Lorusso Alessandro , Perini Tommaso , Piemontese Simona , Marcatti Magda , Lorentino Francesca , Xue Elisabetta , Clerici Daniela , Corti Consuelo , Bernardi Massimo , Assanelli Andrea , Greco Raffaella , Ciceri Fabio , Peccatori Jacopo 
Published: September 2021

IntroductionReducing toxicities while preserving efficacy in allogeneic stem cell transplant (allo-HCT) remains a particularly challenging problem. Different strategies to enhance the antitumor activity without increasing early and late adverse toxicities of the conditioning regimens have been investigated.MethodsThe aim of “AlloTreo” prospective phase 2 clinical trial was to evaluate the efficacy and safety of a conditioning regimen based on Treosulfan (42 g/m2) and fludarabine (https://clinicaltrials.gov/ct2/show/NCT00598624). We enrolled 108 patients with hematological diseases who received a first allo-HCT between June 2005 and January 2011, inside the frame of this trial at our center. Median age at allo-HCT was 49 (21–69) years. Disease Risk Index was low in 14 (13%) patients, intermediate in 73 (67.7%), high in 17 (15.7%), and very high in 4 (3.7%). Donors were human leukocyte antigen (HLA)-matched related in 50 cases, 10/10-matched unrelated in 36, and 9/10-mismatched unrelated in 22. Graft-versus-host disease (GvHD) prophylaxis consisted of cyclosporine-A and methotrexate. Anti-T-lymphocyte globulin (ATLG) was administered in patients receiving unrelated allo-HCT. Stem cell source was mainly peripheral blood stem cells (95%).ResultsConditioning regimen was well tolerated. Full donor chimerism was documented for most patients (88%) at day +30. At 12 years, overall survival (OS) was 41.7% (32.2%–50.9%), progression-free survival (PFS) was 31.7% (23%–40.7%), GvHD-free/relapse-free survival was 20.9% (13.7%–29.1%), cumulative incidence (CI) of relapse was 44.5% (34.9%–53.6%), and transplant-related mortality (TRM) was 22.5% (15.1%–30.9%). CI of acute GvHD grades II–IV was 27.8% (19.7%–36.5%) at 100 days; 12-year CI of chronic GvHD was 40.7% (31.3%–49.9%). Relevant long-term adverse effects were 10 secondary malignancy, 3 fatal cardiovascular events, and 1 late-onset transplant-associated thrombotic microangiopathy. Ten successful pregnancies were reported after allo-HCT. In multivariate analysis, older age (≥60 years) at transplant [hazard ratio (HR), 2.157; p = 0.004] and a high/very high disease risk index (HR, 1.913; p = 0.026) were significantly associated with a lower OS.ConclusionsOverall, our data confirmed the myeloablative potential and safe toxicity profile of full dose Treo (42 g/m2) especially for the younger population.