bluuebunny/crossref_metadata_2025_split huggingface dataset:
UJI SENSITIVITAS EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM) TERHADAP PERTUMBUHAN BAKTERI ESCHERICHIA COLI
Authors: Afriansya Roni 
Published: January 2021

An Escherichia coli bacterium is normal flora bacteria in human body. The excess of bacteria can cause diseases. Garlic has allicin compound, which known as antimicrobial compound.. The research a purpose to determine the antibacterial activity of garlic against the bacteria Escherichia coli at a concentration of garlic and what was the most powerful (effective) hinders the growth of the bacterium Escherichia coli. The research was a laboratory experiment with antimicrobial testing using paper disc diffusion method. Garlic extract was made by the process of maceration. Maceration process conducted over 5 days. Garlic extracted and then tested on the growth of Escherichia coli with three repetitions. Observation was made after 1x24 hours. Then observed a clear zone was formed, the zone was measured by using a ruler. Results of the research noted that garlic extract has the ability to inhibit the growth of bacteria Escherichia coli and seen a proportional relation-ship in each other, concentration of garlic extract become greater as inhibiting the growth of the bacterium Escherichia coli does so. The most effective concentration to inhibit the growth of Escherichia coli bacteria was garlic extract concentration of 75 % with an average diameter of 10.66 mm zone of inhibition and concentration of 100% with an average inhibition zone diameter of 13.33 mm. Garlic can be used as medicine of natural materials dan consume garlic regularly can prevent the growth of escherichia coli bacteria that can not controlled in the body.
PENGARUH PEMBERIAN SUSU TEMPE TERHADAP KADAR HAEMOGLOBIN PADA IBU HAMIL TRIMESTER III
Authors: Yuniwati Yuniwati 
Published: January 2021

The incident of anemia in Bengkulu City was still high (around 45%) and it could be the risk factor of post partum haemorrhagic. Alternative therapeutic that can be developed was the tempe-feeding because high amino acid and vitamin of B 12 in tempe. This research caused to know influence of tempe feeding for average haemoglobin level of pregnant women in 3th semester of pregnancy at BPS Bengkulu City. The design was pre-experiment one group pre and post test, with pregnant women population in 3th semester of pregnancy at BPS Bengkulu City with samples one 12 person. The results showed average haemoglobin level to the pregnant women in 3th semester of pregnancy before intervention was 11.50 gr/dl and after tempe-feeding became 12.41 gr/dl. There was relationship between tempe-feeding to average haemoglobin level with result p=0.005 and mean difference was 0.91. There was relationship between consumption of protein and iron tablets to haemoglobin level. There was no relationship between vitamine C consumption and economic statues to haemoglobin level, tempe-feeding influenced to the improvement average haemoglobin for pregnant women 3th semester of pregnancy. Adviced to health provider to counseling about nutrition of tempe as a alternative food cheaper and high nutrition for the pregnant women.
Índice de massa corporal aumentada: qual a influência sobre a força muscular ventilatória?
Authors: Silva Wasly Santana , Mestre William Santos , Silva Edvan Santos , Santos Junior Jailson de Souza , Viana David Eduardo Santos , Wagmacker Djeyne Silveira 
Published: January 2021

Introdução: A força muscular ventilatória (FMV) e fatores anatômico/biológicos são importantes no funcionamento e manutenção da homeostasia corporal. Dessa maneira, é fundamental o estudo da mecânica respiratória e condições que podem alterá-las. Estudos apontam que a obesidade diminui a Pressão Inspiratória Máxima (PImáx) e Expiratória Máxima (PEmáx), no entanto, esses estudos são contraditórios em seus resultados. Objetivo: Verificar se existe diferença entre a FMV de indivíduos obesos e eutróficos. Métodos: Estudo observacional comparativo, no qual foram avaliados 40 indivíduos de ambos os sexos, divididos em dois grupos: 20 indivíduos com obesidade grau I e 20 indivíduos eutróficos. Foi considerada aumentada a circunferência abdominal (CA) >102 cm para homens e 88 cm para mulheres. Aplicado o teste t de Student não pareado bidirecional para comparação entre a Pressão Inspiratória Máxima (PImáx) e Pressão Expiratória Máxima (PEmáx) dos grupos avaliados. Utilizado o programa BioEstat 5.0 e adotado como significativo um p ˂ 0,05. Resultados: A média da PImáx para obesos e eutróficos foi respectivamente de 147 ± 73 vs 145 ± 70 cmH2O (p = 0,91). Para a PEmáx, a média do grupo obeso e eutrófico foram respectivamente de 133 ± 28 vs 135 ± 27 cmH2O (p = 0,93). Conclusão: Indivíduos sedentários com obesidade grau I associado ao aumento da circunferência abdominal não apresentam diferença na PImáx e PEmáx quando comparados a indivíduos eutróficos.
El valor histórico de las haciendas Malqui-Machay y su incidencia en el aporte de la Identidad Cultural del Cantón La Maná
Authors: Toapanta Caizaluisa Peterson Arturo , Zambrano Cuadro Natalia Geoconda , Llore Chicaiza Wendy Sabrina , Calvopiña León César Enrique 
Published: January 2021

Introducción. Las haciendas Malqui-Machay ubicadas en la parroquia de Guasaganda, cantón la Maná, posee vestigios arqueológicos mismos que se los conocen como la última morada del Inca Atahualpa por los sucesos históricos que han sido de importancia para la historia ecuatoriana ya que habría sido el refugio de los últimos Incas. Estos acontecimientos son un aporte para la identidad cultural del sector gracias a la historia que posee, Sin embargo, presenta debilidades en la conservación de la arqueología y con ello la identidad cultural de la población Lamanense, esto ha sido consecuencia de la devaluación de la infraestructura y por las condiciones climáticas. Objetivo. Preservar el valor histórico de las haciendas Malqui-Machay y su incidencia en la identidad cultural del cantón La Maná. Metodología. Para la presente investigación se trabajó con una muestra de 69 personas en donde se tomó la opinión de profesionales, propietarios de las haciendas y la población de la parroquia de Guasaganda, esta información fue levantada a través de salidas de campo mediante las técnica de la entrevista (5) y encuesta (64),mismas que fueron formuladas con interrogantes estructuradas cerradas; El propósito principal fue recabar información para conocer el criterio y el conocimiento de los pobladores acerca de los hitos históricos que sucedieron en las haciendas Malqui-Machay. Resultados. Según el estudio de la identidad cultural realizado en las haciendas Malqui-Machay se enmarcan importantes resultados ya que estos sitios fortalecen las costumbres y tradiciones de la población gracias a los acontecimientos de cada hacienda y las leyendas existentes en la zona circundante. Con estos datos positivos se procede a realizar el diseño de una guía informativa de patrimonio cultural la cual contenga tres secciones: informativa, leyendas y conservación. Con el propósito fundamental de rescatar parte de la identidad cultural de los habitantes del cantón La Maná. Conclusión. Dentro de las haciendas Malqui-Machay existe un gran potencial turístico cultural el cual aporta en la identidad cultural de los habitantes de la parroquia Guasaganda Cantón La Maná ya que se encuentra una arqueología que se desarrollaron gracias, a los acontecimientos y a la memoria histórica que se han evidenciado en dicho lugar y a las leyendas que han prevalecido en el tiempo y que son un icono para el sector.
Incidencia de las metodologías de enseñanza en las carreras de ciencias administrativas ofertadas por las universidades públicas del DMQ.
Authors: Herrera Enríquez Giovanni , Castillo Páez Sergio , Zambrano Vera Danny , Herrera Sánchez Maybelline Jacqueline , Casanova Villalba César Iván 
Published: January 2021

Introducción: La difusión del conocimiento forma parte de la evolución y el desarrollo humano, en este espacio la educación superior juega un papel primordial en la búsqueda, difusión y construcción del conocimiento. se han desarrollado varios métodos de enseñanza para permitir a los estudiantes asimilen el aprendizaje. Objetivo: Determinar la efectividad de los diversos métodos de enseñanza impartidos por los docentes a los estudiantes en nivel de pregrado, focalizando la perspectiva del estudiante sobre los métodos aplicados por sus docentes y la concepción del aprendizaje. Metodología: esta investigación es de tipo teórica basada en documentos, con la utilización de herramientas como la aplicación de encuestas, dando un resultado descriptivo exploratorio, aplicando un método deductivo analítico. Resultados: los métodos más aplicados por los docentes son conferencias magistrales y el aprendizaje basado en problemas, sin embargo, los métodos de estudios de caso y simulaciones son calificados por los estudiantes como los que brindan mejores resultados para la captación del aprendizaje. Conclusión: Se analizó los resultados de la investigación a los estudiantes del último año de las carreras de Administración de Empresas, Contabilidad y Auditoría de la Universidad Central del Ecuador y de la Universidad de las Fuerzas Armadas ESPE, y se tienen dos conclusiones de trascendencia, la primera que los estudiantes no tienen una correcta interpretación de cada concepto de los diferentes métodos por ende no conciben la diferencia entre su aplicación, la segunda es que los docentes no buscan nuevas formas de llegar a los estudiantes y se encasillan en los métodos típicos, por tal motivo no existe una diferencia de circunstancial en conocimientos.
Training Programme on Applied Research Methodology and SPSS
Authors: Lasker Shamima Parvin 
Published: January 2021

Bangladesh Bioethics Society in cooperation with National Institute of Neuro Science (NINS), Agargoan, Dhaka is going to organized 60 hours (Two weeks) Training Course on Applied Research Methodology and SPSS on February, 2021 for the Post graduate Medical Students of NINS. The course is designed to familiarize the participants with modern tools, techniques and methodologies of research to develop professional knowledge and skills in the field of Health care system. After completion of the course, participants will be expected to undertake research projects independently and to be able to evaluate the research progress at each stage of the process.
This programme is funded by SSRC, Planning Division, Ministry of Planning, Government of the People’s Republic of Bangladesh
Restrained Edge Domination Number of Some Path Related Graphs
Authors: Vaidya S. K. , Ajani P. D. 
Published: January 2021

For a graph G = (V,E), a set S ⊆ V(S ⊆ E) is a restrained dominating (restrained edge dominating) set if every vertex (edge) not in S is adjacent (incident) to a vertex (edge) in S and to a vertex (edge) in V - S(E-S). The minimum cardinality of a restrained dominating (restrained edge dominating) set of G is called restrained domination (restrained edge domination) number of G, denoted by γr (G) (γre(G). The restrained edge domination number of some standard graphs are already investigated while in this paper the restrained edge domination number like degree splitting, switching, square and middle graph obtained from path.
Enfermedad de Coronavirus 2019 (COVID-19). Primera parte
Authors: Valdivieso-Rodriguez Manuel 
Published: January 2021

Se presentan varios artículos preparados por distinguidos médicos peruanos radicados en los EEUU en relación a la pandemia mundial del Coronavirus 2019 (COVID-19). Los artículos están basados en presentaciones efectuadas por estos científicos como parte del programa educativo de la XLVII Convención Anual de la Peruvian American Medical Society (PAMS), que este año se efectuó en forma virtual debido a que la pandemia nos imposibilitó hacerlo en forma presencial en Arequipa, Perú. Las presentaciones virtuales ocurrieron los días 17 y 18 de setiembre, 2020 y fueron realizadas vía Zoom. Estas conferencias virtuales, cortas y precisas, fueron posibles por el coauspicio de la PAMS, la Universidad Peruana Cayetano Heredia de Lima y la Universidad Católica de Santa María de Arequipa.
Vademécum para el manejo de las complicaciones y comorbilidades de la Diabetes Mellitus
Authors: Morales-Soto Nelson Raúl 
Published: January 2021

El autor, distinguido Endocrinólogo, menciona en la Introducción: “Las enfermedades crónicas no transmisibles son una causa importante de morbilidad y mortalidad en el mundo, incluso en países en desarrollo. El cuidado de los pacientes con estas afecciones como enfermedad mental enfermedad cardiovascular, cáncer, enfermedad pulmonar obstructiva crónica y diabetes mellitus afecta negativamente los presupuestos de salud de la mayoría de países, debido no solo a la mortalidad que producen, sino también por la discapacidad que ocasionan comprometiendo la calidad de vida de las personas afectadas….Con esta perspectiva hemos planificado la elaboración de la presente publicación para ayudar a los médicos generales, internistas, endocrinólogos, nefrólogos, oftalmólogos, cirujanos vasculares y a los diferentes especialistas involucrados en el cuidado de los pacientes con diabetes mellitus, en la mejor toma de decisiones de tratamiento brindándoles la evidencia clínica disponible en este vademécum que hace honor a su definición: 'libro de poco volumen y de fácil manejo para consulta inmediata de nociones e informaciones fundamentales'”.
Two-Year Outcome From Combining Cryoballoon Ablation and Left Atrial Appendage Closure: CLACBAC Study
Authors: Ren Zhongyuan , Zhang Jingying , Wang Songyun , Jia Peng , Li Xiang , Zhang Jun , Guo Rong , Li Hailing , Li Shuang , Yang Haotian , Zheng Yixing , Meng Weilun , Xu Yawei , Zhao Dongdong 
Published: January 2021

Objective: Catheter ablation combined with left atrial appendage closure (LAAC) has emerged as a promising strategy for atrial fibrillation (AF) patients at high risk for stroke or with contraindications for oral anticoagulants (OACs). But the evidence for the long-term safety and efficacy of a combined procedure using cryoballoon ablation (CBA) with LAAC is still insufficient.Methods: From October 2015 to December 2017, a total of 76 consecutive non-valvular, drug-refractory AF patients who underwent a combined procedure of CBA and LAAC are included. Peri- and post-procedural safety and efficacy were evaluated through scheduled follow-ups and transesophageal echocardiography (TEE).Results: A total of 74 patients (97.4%) underwent the combined procedure and achieved instant pulmonary vein isolation and satisfactory LAAC. With a mean follow-up time of 23.7 ± 11.0 months, the recurrence of atrial arrhythmia was recorded in 35 patients (48.0%). In addition, a survival analysis shows a non-significant higher recurrence in persistent AF (p = 0.48). The overall OAC withdrawal rate was 97.2%, and one patient (1.4%) had a lethal hemorrhagic stroke while on single antiplatelet therapy. For safety concerns, the overall mortality was 2.7%, which resulted from one case of myocardial infarction on OAC and one hemorrhagic stroke, as mentioned. No other major hemorrhagic events occurred. Among the 72 patients (94.7%) who underwent TEE, one patient (1.4%) had device-related thrombosis and one patient (1.4%) had prominent residual flow (over 3 mm). Both were prescribed long-term OACs without severe complications occurring.Conclusions: Combining CBA with LAAC in a single procedure achieved considerable long-term safety and efficacy, providing a promising strategy for AF management.
The Differential Diagnosis of Hypopigmented Mycosis Fungoides and Vitiligo With Reflectance Confocal Microscopy: A Preliminary Study
Authors: Liu Huaxu , Wang Leilei , Lin Yan , Shan Xiaofeng , Gao Min 
Published: January 2021

Objective: To investigate the role of reflectance confocal microscopy (RCM) in the differential diagnosis of hypopigmented mycosis fungoides (HMF) and vitiligo.Methods: Cases with persistent hypopigmented patches, suspicious of early stage vitiligo, or HMF were imaged with RCM. The melanin contents and inflammatory conditions of the epidermis and superficial dermis of the lesions were compared with the same layers of the adjacent skin, and then, the imaged lesions were biopsied and analyzed by histology.Results: 15 cases were enrolled in this study, and based on the RCM findings, there was just slight or moderate reduction of melanin but no melanin absence in the basal cell layer of HMF lesions. The finding of monomorphous weakly refractile, oval to round cells on the basis of vesicle-like dark space was clearly elucidated in the epidermis of the lesions by RCM, which indicates the Pautrier's microabscesses on histopathology. Among those 15 cases, 13 cases were identified as HMF, and the other two cases were vitiligo, based on RCM findings, which were confirmed by histology analysis.Conclusions: The RCM findings correlated well with histology results in the screening of HMF, which indicates the RCM is an important tool in the early detection and differential diagnosis of HMF.
Cardioprotective Effect of Echinatin Against Ischemia/Reperfusion Injury: Involvement of Hippo/Yes-Associated Protein Signaling
Authors: Niu Jieting , Li Yanguang , Song Xiang , Liu Yunfeng , Li Ying , Li Ya 
Published: January 2021

Background: Echinatin (Ech) has been reported to exert antioxidant and anti-inflammatory activities. In this study, we aimed to characterize the functional role of Ech in myocardial ischemic/reperfusion (MI/R) injury and elucidate its underlying mechanism of action.Method: We established in vivo and in vitro models of MI/R injury to determine the effect of Ech on MI/R injury. Gene expression was examined using quantitative real-time polymerase chain reaction and western blotting. Myocardial infarction was assessed using tetrazolium chloride staining and the degree of myocardial injury was evaluated by measuring lactate dehydrogenase (LDH) and creatine kinase-myocardial band (CK-MB) levels. Cell apoptosis was detected using the terminal deoxynucleotidyl transfer-mediated dUTP nick end-labeling (TUNEL) assay. The viability of H9c2 cells was determined using Cell Counting Kit-8 assay.Results: MI/R induced myocardial infarction, which was mitigated by Ech treatment. Moreover, Ech treatment resulted in a marked decline of LDH and CK-MB levels in the serum and myocardium of MI/R rats. Ech treatment also restrained cardiomyocyte apoptosis in vivo and in vitro, as evidenced by reduction in LDH release, the number of TUNEL-positive cells, and caspase-3 activity. Furthermore, Ech administration inhibited MI/R-induced activation of Hippo/Yes-associated protein signaling in vivo and in vitro, as indicated by inhibition of mammalian sterile 20-like protein kinase 1, large tumor suppressor one, and YAP phosphorylation and promotion of YAP nuclear translocation. However, silencing of YAP counteracted the protective effect of Ech on hypoxia/reoxygenation-induced myocardial injury in vitro.Conclusion: Ech exerted its protective effect against MI/R injury at least partially by suppressing the Hippo/YAP signaling pathway, providing novel insights into the remission of MI/R injury.
Formulasi Hydrogel Eye Mask Berbasis Ekstrak Limbah Kepala Udang Putih (Litopenaeus vannamei) Sebagai Suplemen dan Relaksasi Mata Lelah
Authors: Okwani Yustian , Halid Nurhatidjah Awaliyah , Hasanuddin Silviana , Djunaidin Djunaidin , Hikmat Deo Julian 
Published: January 2021

Kepala udang merupakan salah satu limbah yang belum dimanfaatkan namun mengandung Astaksantin yang dapat dimanfaatkan sebagai pengatasan terhadap mata lelah. Meningkatnya pengunaan komputer menyebabkan gangguan terhadap penglihatan yang dinamakan Computer Vision Syndrome (CVS) yaitu suatu gejala yang dapat menyebabkan berbagai keluhan antara lain mata lelah dan kering, hal tersebut menjadi tujuan penelitian ini yaitu memformulasi kedalam bentuk sediaan dari ekstrak etanol kepala udang putih (Litopenaeus vannamei). Salah satu sediaan mata yang dapat digunakan dengan nyaman bagi pengguna yaitu Hydrogel EyeMask.
Jenis penelitian yang digunakan adalah penelitian eksperimental. Preparasi penelitian dilakukan dengan penyiapan ekstrak etanol kepala udang putih (Litopenaeus vannamei) dengan metode maserasi. Formulasi hydrogel Eye Mask dengan menggunakan Na-alginat dan xanthan gum sebagai basis. Sediaan dievaluasi kestabilan dan karakteristik fisik hydrogel Eye Mask dievaluasi melalui pengamatan organoleptis, daya mengembang, dan nilai pH.
Hasil evaluasi menunjukkan hydrogel Eye Mask tidak mengalami perubahan organoleptis selama 12 minggu dan memiliki kemampuan menahan air yang baik. Selain itu, pengukuran daya mengembang menunjukkan pada pengukuran minggu pertama yaitu pada jam ke-1 dan jam ke-2 hingga pada jam ke-3 berturut-turut 42,10%, 48,56%, 72,11% dengan nilai pH 6,15±0,04. Hydrogel yang dihasilkan pada penelitian ini memiliki karakteristik dan stabilitas fisik yang baik sehingga diharapkan dapat digunakan sebagai sediaan suplemen dan relaksasi mata.
CORRELATION BETWEEN THE LYMPHOCYTE-MONOCYTE RATIO AND CYTOKINES IN CHRONIC INFLAMMATION IN RATS TREATED WITH ALLOGENEIC MESENCHYMAL STEM CELLS
Authors: Petryk Nataliia , Shevchenko Oleksandr 
Published: January 2021

The chronic inflammatory process is a pathological condition characterized by an ongoing active inflammatory response and tissue destruction. Many studies show that chronic inflammation can play a severe role in various age-related diseases, including diabetes, cardiovascular, and autoimmune diseases. One of the important but poorly studied factors affecting the regulation of chronic inflammation is the regulatory activity of MSCs. In this regard, the study of mesenchymal stem cells preventing chronic inflammation in the experiment is an important area of modern pathology.
On the one hand, increased cytokines, such as α-TNF, IL 6, and CRP, are reliable tools in diagnostic different inflammatory processes, especially chronic inflammation. On the other hand, nowadays, we need a more straightforward and not so expensive criterion for this purpose, for instance, a common total blood count and LMR. For the first time, we investigated how trustworthy can be LMR and how possible to use it in chronic inflammation in rats to achieve prognostic goals.
This study investigated the correlation between α-TNF, IL-6, and CRP with LMR in rats' plasma in groups with chronic carrageenan inflammation and chronic inflammation with local injection of MSCs into the affected area. The study involved 132 adult male rats (180-220g), which were divided into groups. The inflammation model was chronic aseptic myositis caused by an intramuscular injection of 10mg λ-carrageenan (Sigma-Aldrich GmbH). Our experimental groups of rats were treated with MSCs (the injection into the inflamed site) in the amount of 1-2 million cells once. Blood sampling was performed from 6 hours to 28 days. We calculated our results using Statistica (data analysis software) version 13. For comparison, we used one-way ANOVA, Turkey's post hoc test, where p <0.05 was considered statistically significant.
In our experiment, the correlation between levels of α-TNF, IL-6, and CRP with lymphocyte-monocyte ratio in rats was described for the first time, demonstrating the suppression of chronic inflammation through MSCs.
Geoffrey Chaucer, The Merchant’s Tale and the Dialectic of Elevation
Authors: Fruoco Jonathan 
Published: January 2021

Geoffrey Chaucer pose dans The Canterbury Tales un regard unique sur l’évolution de la poésie anglaise durant le Moyen Âge. L’alternance de genres et de styles poétiques différents lui permet de refléter tout le potentiel de la littérature par le biais d’un réagencement des images, symboles et conventions qui la définissent. Néanmoins, ce qui fait la force de Chaucer dans The Canterbury Tales, est sa capacité à développer un dialogue entre les différents récits constituant l’œuvre, ainsi que sa facilité à renverser nos attentes en extrayant son public d’un roman de chevalerie pour le propulser dans l’univers carnavalesque du fabliau, comme c’est le cas dans The Merchant’s Tale. En jouant avec l’imaginaire de l’arbre et du fruit, Chaucer nous prive dans ce conte de toute élévation et fait de son poirier un arbre inversé.