bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of the Korean patient placement criteria matching among individuals with alcohol-related problems with treatment completion and abstinence: an observational study
Authors: Hong Jiyoung , Shin Seon-Hi , Kim Ji Eun , Lee Sang Kyu , Oh Hong Seok , Na Euihyeon , Cho Hyun Ji , Roh Sungwon 
Published: December 2024

Abstract
Background
The American Society of Addiction Medicine Patient Placement Criteria (ASAM PPC) are guidelines for matching addiction patients to an optimal level of care (LOC). South Korea lacked a systematic approach to assigning alcohol use disorder patients to suitable treatment. To address this, Park et al. translated the ASAM PPC into Korean, creating the Korean Patient Placement Criteria (KPPC). We aim to assess the efficacy of the KPPC by evaluating whether receiving KPPC-matched treatment would result in longer periods of alcohol abstinence and higher number of treatment program completion.

Methods
This is an observational, multi-site study of 225 individuals with hazardous alcohol use or alcohol dependence, defined by Alcohol Use Disorder Identification Test score of 10 or more for men, and 6 or more for women. We evaluated patients using KPPC at baseline and one-month follow-up visits and recommended a LOC at every visit. Patients freely chose to receive KPPC-matched treatment or not. We examined the duration of alcohol abstinence and number of one-month treatment program completion within a three-month period.

Results
Of the 225 participants, 47 never pursued their matched level of care treatment, 54 pursued it once, and 124 pursued it twice. Individuals who received KPPC-matched treatment once had significantly higher odds of achieving alcohol abstinence (OR = 2.23), with greater odds when they received KPPC-matched treatments twice (OR = 2.88). The association was also significant for treatment completion, with greater odds of completing treatment program for one KPPC-matched treatment (OR = 3.28) and two KPPC-matched treatments (OR = 3.19).

Conclusions
Individuals who followed the KPPC matched level of care had longer periods of alcohol abstinence and better treatment completion. Our results should encourage community addiction management centers and hospitals to adopt KPPC for classifying treatment settings for alcohol use disorder patients. Further research is warranted to maximize the potential benefits of KPPC.
The genetics and genomics of milk thistle: unlocking its therapeutic potential through modern breeding and biotechnological innovations
Authors: Tolangi Priskila , Shim Jeehyoung , Sumabat Raña Mae , Kim Sunghan , Park Hyun-Seung , Do Kim Kyung , Kim Hyun Uk , Lee Sanghyun , Chin Joong Hyoun 
Published: December 2024

AbstractMilk thistle (Silybum marianum) is a Mediterranean herb renowned for its liver-protective, antioxidant, anti-inflammatory, and detoxifying properties, primarily attributed to the bioactive compound silymarin. Recent studies have also highlighted its potential efficacy against COVID-19, contributing to the growing demand for milk thistle dietary supplements, particularly for liver health and immunity support. Milk thistle seeds, rich in silymarin and unsaturated fatty acids, hold significant industrial value as both medicinal and oilseed crops. To meet the growing demand, it is essential to develop standardized seeds, cultivation practices, and extraction methods aimed at maximizing yields of silymarin and other valuable metabolites. Recent advancements in genetic and genomic research, including the development of the first reference genome of S. marianum, have played a pivotal role in elucidating the biosynthesis pathways of silymarin and optimizing phytochemical production. This review highlights recent advancements in the genetics, genomics, and biochemistry of milk thistle, with particular emphasis on the importance of diverse genetic resources and AI-driven phenomics strategies, such as hyperspectral and RGB imaging, for high-yield and chemotype breeding. Further, feasibility of developing elite cultivars through molecular approaches, such as genome editing and metabolic engineering, is also discussed as the new traits obtained this way would be key to enhancing the commercial value of milk thistle in light of mass production of phytochemicals to meet rising market demands.
Rapid human movement and dengue transmission in Bangladesh: a spatial and temporal analysis based on different policy measures of COVID-19 pandemic and Eid festival
Authors: Islam Jahirul , Hu Wenbiao 
Published: December 2024

Abstract
Background
Rapid human movement plays a crucial role in the spatial dissemination of the dengue virus. Nevertheless, robust quantification of this relationship using both spatial and temporal models remains necessary. This study aims to explore the spatial and temporal patterns of dengue transmission under various human movement contexts.

Methods
We obtained district-wise aggregated dengue incidence data from the Management Information System, Directorate General of Health Services of Bangladesh. The stringency index (SI), along with eight individual policy measures (from the Oxford Coronavirus Government Response Tracker database) and six mobility indices (as measured by Google's Community Mobility Reports) were obtained as human movement indicators. A multi-step correlative modelling approach, including various spatial and temporal models, was utilized to explore the associations of dengue incidence with the SI, fourteen human movement indices and the Eid festival.

Results
The global Moran’s I indicated significant spatial autocorrelation in dengue incidence during the pre-pandemic (Moran’s I: 0.14, P < 0.05) and post-pandemic periods (Moran’s I: 0.42, P < 0.01), while the pandemic period (2020–2022) showed weaker, non-significant spatial clustering (Moran’s I: 0.07, P > 0.05). Following the pandemic, we identified the emergence of new dengue hotspots. We found a strong negative relationship between monthly dengue incidence and the SI (rspearman: − 0.62, P < 0.01). Through the selection of an optimal Seasonal autoregressive integrated moving average model, we observed that the closure of public transport (β = − 1.66, P < 0.10) and restrictions on internal movement (β = − 2.13, P < 0.10) were associated with the reduction of dengue incidence. Additionally, observed cases were substantially lower than predicted cases during the period from 2020 to 2022. By utilising additional time-series models, we were able to identify in 2023 a rise in dengue incidence associated with the Eid festival intervention, even after adjusting for important climate variables.

Conclusions
Overall, rapid human movement was found to be associated with increased dengue transmission in Bangladesh. Consequently, the implemention of effective mosquito control interventions prior to large festival periods is necessary for preventing the spread of the disease nationwide. We emphasize the necessity for developing advanced surveillance and monitoring networks to track real-time human movement patterns and dengue incidence.

Graphical Abstract
Open Protocols, the new standard for acoustic tracking: results from interoperability and performance tests in European waters
Authors: Aspillaga Eneko , Bruneel Stijn , Alós Josep , Verhelst Pieterjan , Abecasis David , Aarestrup Kim , Birnie-Gauvin Kim , Afonso Pedro , Palmer Miquel , Reubens Jan 
Published: December 2024

Abstract
Background
The lack of compatibility between acoustic telemetry equipment from different manufacturers has been a major obstacle to consolidating large collaborative tracking networks. Undisclosed encrypted signal coding protocols limit the use of acoustic telemetry to study animal movements over large spatial scales, reduce competition between manufacturers, and stifle innovation. The European Tracking Network, in collaboration with several acoustic telemetry manufacturers, has worked to develop new transparent protocols for acoustic tracking. The results are energy-efficient transmission protocols accessible to all researchers and manufacturers. Today, the Open Protocols (OP) are already available to manufacturers and developers, and the first transmitters and receivers to implement them are already in the water.

Results
The main objective of this study was to confirm the compatibility between devices from different manufacturers using OP, characterise the acoustic range of each transmitter–receiver manufacturer combination, compare the detection efficiency to the standard protocols used at present (R64K and encrypted protocols), and assess its robustness against spurious detections. An international collaborative effort was made to conduct acoustic range tests in four main aquatic habitats: a river, a coastal lagoon, a coastal habitat, and the open sea. Receivers and transmitters from different manufacturers were deployed at increasing distances from each other using the same experimental design at each location. The decay of detection probability with distance was modelled for each transmitter–receiver manufacturer combination by applying logistic regression using a Bayesian approach. Furthermore, to thoroughly assess performance differences in an applied research context, we conducted a direct field comparison between groups of smolts tagged with OP and R64K tags, tracking their migration to the sea.

Conclusions
Our results confirm full compatibility between the tested devices, with negligible differences in the measured acoustic ranges between OP manufacturers and when compared to encrypted protocols. The OP was also robust against spurious detections, and the field comparison between OP and R64K showed equal performance. We hope these novel insights will encourage international research groups to promote OP-based studies to ensure compatibility and maximise the benefits of acoustic telemetry networks.
Survey of psychological resilience among university students majoring in long-term-care–related disciplines in Taiwan
Authors: Chang Chia-Chen , Tung Chen-Yin , Fan Su-Hao , Huang Wei-Hsiang 
Published: December 2024

Abstract
Background
The psychological resilience of university students majoring in long-term-care (LTC)–related disciplines is crucial for workforce retention and effective care provision in this field. This study aims to investigate the differences in levels of psychological resilience among these students in Taiwan.

Methods
This cross-sectional study involved 258 participants selected via stratified random sampling from 23 universities across Taiwan from November 2021 to November 2022, representing a diverse educational context. The research instrument used was the Resilience Scale for Adults, a validated psychological resilience questionnaire. The independent variables included participants’ demographic data, while the dependent variables encompassed five dimensions of resilience: personal strength, family cohesion, social resources, social skills, future organizational style, and total resilience score. Data analysis was performed using descriptive statistics, independent-samples t-tests, analysis of variance, and multiple regression analysis.

Results
Participants with LTC work experience and leadership roles in campus clubs demonstrated significantly higher scores in personal strength (LTC: t = 2.04, p = 0.04, d = 0.29; leadership: t = 2.89, p = 0.01, d = 0.45), social resources (leadership: t = 2.47, p = 0.01, d = 0.34), social skills (leadership: t = 4.51, p = 0.01, d = 0.62), and future organizational style (LTC: t = 2.72, p = 0.01, d = 0.39). Higher academic performance was linked to greater personal strength, social resources, future organizational style, and total resilience (F = 4.69–3.12, p < 0.05). Regression analysis confirmed the predictive value of leadership experience and LTC work on various resilience dimensions. These results underscore the importance of practical exposure and extracurricular engagement in fostering resilience.

Conclusion
Students engaged in club activities, leadership roles, and LTC work displayed higher psychological resilience. Educational institutions should foster club participation, leadership experiences, and partnerships with workplaces to enhance student resilience and professional readiness.
A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model
Authors: Thompson Emily G. , Spead Olivia , Akerman Suleyman C. , Curcio Carrie , Zaepfel Benjamin L. , Kent Erica R. , Philips Thomas , Vijayakumar Balaji G. , Zacco Anna , Zhou Weibo , Nagappan Guhan , Rothstein Jeffrey D. 
Published: December 2024

AbstractThe G4C2 hexanucleotide repeat expansion in C9ORF72 is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models of C9-ALS/FTD useful for therapeutic development has proven challenging due to the intricate interplay of genetic and molecular factors underlying this neurodegenerative disorder, in addition to species differences. This study presents a robust investigation of the cellular pathophysiology and behavioral outcomes in a previously described AAV mouse model of C9-ALS expressing 66 G4C2 hexanucleotide repeats. The model displays key molecular ALS pathological markers including RNA foci, dipeptide repeat (DPR) protein aggregation, p62 positive stress granule formation as well as mild gliosis. However, the AAV-(G4C2)66 mouse model in this study has marginal neurodegeneration with negligible neuronal loss, or clinical deficits. Human C9orf72 is typically associated with altered TAR DNA-binding protein (TDP-43) function, yet studies of this rodent model revealed no significant evidence of TDP-43 dysfunction. While our findings indicate and support that this is a highly valuable robust and pharmacologically tractable model for investigating the molecular mechanisms and cellular consequences of (G4C2) repeat driven DPR pathology, it is not suitable for investigating the development of disease- associated TDP-43 dysfunction or clinical impairment. Our findings underscore the complexity of ALS pathogenesis involving genetic mutations and protein dysregulation and highlight the need for more comprehensive model systems that reliably replicate the multifaceted cellular and behavioral aspects of C9-ALS.
It is not just your opinion. Gender equity endorsement of Latin American students and their peers at school
Authors: López-Hornickel Natalia , Carrasco Diego , Lay Siugmin , Treviño Ernesto 
Published: December 2024

Abstract
Promoting adhesion to attitudes toward gender equity is critical to achieving more equal societies, yet endorsement of gender equality among Latin American adolescents remains lower than global averages. This study investigates the role of school environments, civic knowledge, and authoritarianism in shaping gender equity attitudes among 8th-grade students in Chile, Colombia, the Dominican Republic, Mexico and Peru, using data from the International Civic and Citizenship Education Study (ICCS) 2016. Fitting different regression models, we explore the relationships between individual socioeconomic status, classroom practices, and school-wide ideological climates on gender equity endorsement. Findings highlight the pivotal influence of civic knowledge and open classroom discussions as protective factors against authoritarian beliefs, which are negatively associated with gender equity support at both individual and contextual levels. Moreover, peer-group ideological climates significantly shape student attitudes, demonstrating the importance of school environments in fostering or hindering egalitarian beliefs. We discussed the role of school practices in the promotion of gender equity. These findings contribute to the global goal of citizenship education and the Sustainable Development Goals (SDG), particularly Goal 5, emphasising the role of schools in promoting democratic and gender-equitable values.
Pre- and coseismic electromagnetic signals of the Nepal earthquake of 03 november 2023
Authors: Manglik Ajay , Suresh M. , Demudu Babu M. , Pavankumar G. 
Published: December 2024

Abstract
Electromagnetic (EM) signals from a seismogenic zone a few weeks to a few days before an earthquake are considered as a promising attribute in earthquake precursory studies. EM perturbations, termed as the coseismic electromagnetic perturbations, also occur within the source zone at the onset of an earthquake and at recording sites during the passage of seismic waves. In the present study, we have analyzed the coseismic electromagnetic perturbations of the M 6.4 Nepal earthquake of 2023-11-03 and its main aftershock (M 5.6) of 2023-11-06, recorded at eight long-period magnetotelluric (LMT) sites installed in profile mode in the Ganga Basin about 150 to 250 km south-west of the earthquake epicenter. The time series were detrended, bandpass filtered, and rotated in the radial and transverse directions using back-azimuth. These time series mimic seismograms and show EM inductions corresponding to the arrival of the P, S and surface waves. Amplification of the surface wave at sites in the middle sector of the profile covering the Sharda depression having thick sedimentary succession and decrease in the amplitude at the southernmost site at the edge of the depression highlight the role of geological heterogeneities in controlling the EM induction. The presence of two very low amplitude consistent peaks at most sites, spread over a profile length of about 120 km, preceding the earthquake by 70 s and 43 s, respectively, is enigmatic. These signals arrive at most sites almost simultaneously and have peak-to-peak amplitude in the range of -0.07 to + 0.11 µV/m and −0.04 to + 0.07 µV/m, respectively, at fourth site. This is probably the first reporting of such preseismic electromagnetic signals in EM time series. We infer that these signals are possibly linked to the fast propagating EM waves generated during the final stage of the earthquake source zone preparation just before the initiation of the rupture. These signals need to be explored in the future for understanding of the causative physical processes. The results also reveal on average about 5 times reduction in the amplitude of the surface wave-induced electric fields with the drop in the earthquake magnitude from 6.4 to 5.6.

Graphical Abstract
Reconstruction of high-resolution paleomagnetic variations in the middle Gauss chronozone, including the upper and lower boundaries of the Mammoth reversed subchronozone
Authors: Tanimoto Akihiro , Okada Makoto , Hayashi Ryota 
Published: December 2024

AbstractIn this study, we provide paleomagnetic records, including the upper and lower boundaries of the Mammoth reversed subchronozone, reconstructed from a continuous outcrop of the upper marine Pliocene in the southernmost part of the Boso Peninsula, which is more than 200 m thick. In this interval, the Mammoth reversed subchronozone was recognized in an interval of approximately 50 m thickness, including a polarity transition zone at its lower boundary of approximately 10 m thickness. Simultaneously, the upper boundary showed no polarity transition zone and a rapid polarity reversal, suggesting a probable lack of strata. Several significant variations were recognized in the paleomagnetic directions in the middle Gauss chronozone, some of which may qualify as new geomagnetic excursions. The relative paleointensities (RPIs) obtained in this study are consistent in their character of change with those reported from deep-sea cores in the distant Caribbean Sea and the equatorial Pacific, indicating the potential of stratigraphic correlation using RPI. The RPI around the lower Mammoth boundary was significantly attenuated compared to the average of the entire section. On the other hand, the virtual geomagnetic pole (VGP) path of the lower Mammoth boundary shows a rapid shift from the southern hemisphere to the northern hemisphere during transition. This movement passes through regions affected by non-axial dipole fields. Following this, the RPI shows a recovery trend, and the VGP stabilizes in the southern hemisphere, forming clusters that align with records from Italy and Hawaii. This sequence offers significant insights into changes in the axial dipole field during geomagnetic polarity reversals.
Graphical Abstract
A high-resolution in situ X-ray diffraction study of mineral transitions due to post-hydration heating in CM chondrite meteorites
Authors: Jenkins Laura E. , King Ashley J. , Lee Martin R. , Daly Luke , Thompson Stephen P. , Day Sarah J. , Saunders Lucy , Martin Pierre-Etienne , Bintang Fahkri 
Published: December 2024

Abstract
The effects of post-hydration heating over a broad range of temperatures are evident in many Mighei-like carbonaceous (CM) chondrites as a variety of mineral transitions. To better understand these processes and how a CM chondrite’s starting composition may have affected them, we experimentally heated two meteorites with different degrees of aqueous alteration, Allan Hills 83100 and Murchison, at 25 °C temperature steps from 200 °C to 950 °C and 300 °C to 750 °C, respectively. During heating, synchrotron in situ X-ray diffraction patterns were collected. With the exception of calcite decomposition and its products, most mineral transitions were unaffected by starting composition. Key observations include: (1) partial decomposition of tochilinite at 200 °C, which indicates that tochilinite breakdown might be a two-stage process due to its intergrown layers of brucite/amakinite and mackinawite; (2) the breakdown of serpentine occurring at 300 °C with transitional phases appearing at 525 °C and 575–600 °C, while secondary olivine formed at 600 °C; (3) cronstedtite decomposing faster than lizardite, (4) the formation of secondary enstatite at 750 °C, and (5) calcite decomposition temperature differing significantly between meteorites, occurring at 725 °C and 575 °C in ALH 83100 and Murchison, respectively. The results for calcite are likely controlled by differences in its microstructure and chemical composition, related to the meteorite’s impact history and degree of aqueous alteration. The difference in calcite decomposition temperature also explains the contrasts in the observed breakdown products, with clinopyroxene occurring in both meteorites, and oldhamite only in ALH 83100. Mineral transitions due to post-hydration heating have been characterized with a high resolution XRD method, enabling a better understanding of processes occurring on the parent asteroids of CM chondrites.

Graphical Abstract