bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Physical Activity Just-in-time Adaptive Intervention Designed in Partnership With a Predominantly Black Community: Virtual, Community-Based Participatory Design Approach
Authors: Robles Maria Cielito , Newman Mark W , Doshi Aalap , Bailey Sarah , Huang Linde , Choi Soo Ji , Kurien Chris , Merid Beza , Cowdery Joan , Golbus Jessica R , Huang Christopher , Dorsch Michael P , Nallamothu Brahmajee , Skolarus Lesli E 
Published: December 2021

Background
Black people are disproportionally impacted by hypertension. New approaches for encouraging healthy lifestyles are needed to reduce hypertension and promote health equity in Black communities.

Objective
In this report, we describe the early-stage, virtual design of a just-in-time adaptive intervention (JITAI) to increase physical activity in partnership with members of a low-income, predominantly Black community.

Methods
The hallmark of JITAIs is highly contextualized mobile app push notifications. Thus, understanding participants' context and determinants of physical activity are critical. During the height of the COVID-19 pandemic, we conducted virtual discovery interviews and analysis guided by the Behavior Change Wheel (which focuses on participants' capacity, opportunity, and motivation to engage in physical activity), as well as empathy mapping. We then formed a community-academic participatory design team that partnered in the design sprint, storyboarding, and paper prototyping.

Results
For this study, 5 community members participated in the discovery interviews, 12 stakeholders participated in the empathy mapping, 3 community members represented the community on the design team, and 10 community members provided storyboard or paper prototyping feedback. Only one community member had used videoconferencing prior to partnering with the academic team, and none had design experience. A set of 5 community-academic partner design principles were created: (1) keep users front and center, (2) tailor to the individual, (3) draw on existing motivation, (4) make physical activity feel approachable, and (5) make data collection transparent yet unobtrusive. To address community-specific barriers, the community-academic design team decided that mobile app push notifications will be tailored to participants’ baseline mobility level and community resources (eg, local parks and events). Push notifications will also be tailored based on the day (weekday versus weekend), time of day, and weather. Motivation will be enhanced via adaptive goal setting with supportive feedback and social support via community-generated notifications.

Conclusions
We completed early-stage virtual design of a JITAI in partnership with community participants and a community design team with limited design and videoconferencing experience. We found that designing JITAIs with the community enables these interventions to address community-specific needs, which may lead to a more meaningful impact on users' health.
MENSURANDO A GOVERNANÇA DE ORGANIZAÇÕES NÃO GOVERNAMENTAIS: PROPOSTA DE ÍNDICE DE GOVERNANÇA
Authors: Lacruz Adonai , Nossa Valcemiro , Rosa Lemos Katarina , De Andrade Guedes Thiago 
Published: December 2021

Objetiva-se propor um Índice de Governança para o Terceiro Setor (IGov3S) que expresse o perfil de governança das Organizações Não Governamentais (ONGs). Para tanto, foram coletados dados de 108 ONGs do segmento meio ambiente com atuação no Brasil por meio de levantamento documental. Os dados foram analisados por meio de análise de correspondência múltipla (dimensões e pesos do IGov3S), análise de cluster (identificação dos níveis do IGov3S) e análise de variância com teste post-hoc Hochberg (validação do IGov3S). Dessas análises, foram identificadas seis dimensões de governança, a partir das quais foi desenvolvido o IGov3S. Em seguida, foram apurados quatro perfis distintos de governança, resultando na classificação da qualidade do IGov3S em quatro níveis. Os resultados desta pesquisa podem contribuir com pesquisadores interessados nesta temática que podem se valer do IGov3S, como medida composta de governança no setor sem fins lucrativos, seja como variável dependente, independente ou de controle em seus estudos empíricos, contornando restrições metodológicas decorrentes da correlação entre os indicadores geralmente utilizados como proxy para mensuração da governança.
Genetic variants identified in children with recurrent infections
Authors: Levina A. S. , Suspitsin E. N. , Skripchenko N. V. , Goleva O. V. , Ibragimova O. M. 
Published: December 2021

Currently, the most effective way to diagnose hereditary defects of the immune system is molecular genetic research, the results of which are evaluated in conjunction with the data of clinical and laboratory studies.Aims of the sudy: to evaluate the frequency and spectrum of rare genetic variants associated with the development of primary immunodeficiency (PID) in children with recurrent infections.Materials and methods: DNA samples from 113 children with recurrent infections were analyzed by targeted multigene sequencing of 338 PID-associated genes. Results: Pathogenic variants appropriate to the potential diagnosis of PID were identified in 8% of patients. Interestingly, 47.8% of children had variants associated with auto-inflammatory disorders.
Hemorrhagic colitis syndrome in children: the etiological structure in the infectious diseases clinic
Authors: Molochkova O. V. , Kovalev O. B. , Shamsheva O. V. , Sakharova A. A. , Sokolova N. V. , Galeeva E. V. , Korsunsky A. A. , Davidenko N. V. 
Published: December 2021

The range of differential diagnostic search in the development of hemorrhagic colitis (hemocolitis) is wide enough and includes infectious and non-infectious factors. Purpose: clinical, laboratory and etiological analysis of bacterial diarrhea occurring with hemorrhagic colitis in the infectious diseases department.Materials and methods: a retrospective study of 141 case histories of those hospitalized in the infectious diseases department of the2 Children's City Clinical Hospital No. 9 named after G.N. Speransky of Moscow in 2019—2021 patients with clinical picture of hemocolitis. Hemocolitis was determined on the basis of macroscopic and microscopic signs (in scatology — mucus, leukocytes, erythrocytes) signs. All patients underwent routine laboratory examinations. The etiology was verified using modern methods of laboratory diagnostics (bacteriological analysis of feces, Latex test, ICA, ELISA, PCR, IHR).Results. There were 137 patients with infectious hemocolitis. Inflammatory bowel disease was diagnosed in 3 children, anus fissure — in 1 child. Young children under 3 years of age prevailed (77%). The etiology of infectious hemocolitis was deciphered in 47 patients (34%). Salmonellosis (36%) and shigellosis (36%) prevailed. Campylobacteriosis, clostridiosis-dificile and klebsiellosis accounted for 11%, 9% and 6% of cases, respectively. Yersiniosis was detected in 1 child at the age of 5 months. The severe form was found in 5.8% of cases, in most cases with shigellosis. Symptoms of intoxication and febrile fever were expressed in all patients, vomiting — in 28.5%, abdominal pain — in 94%, mesenteric adenitis on ultrasound — in 15%, diarrhea with a frequency of more than 5 times a day — in 84%, dehydration — in 64%, intercurrent diseases (ARVI, pneumonia) — in 41.3% of cases. Inflammatory changes in infectious hemocolitis were manifested by an increase in C-reactive protein in 71% (23.91 ± 24.17 mg/l), leukocytosis — in 69% (11.58 ± 3.52 х103 / μl), thrombocytosis — in 26%, an increase in the relative number of stab neutrophils in the general blood test in 78% of cases (10.95 ± 0.4%).Conclusions. Differential diagnostic search in the development of hemocolitis should include modern diagnostic methods, if necessary, additional instrumental studies and specialist consultations to exclude inflammatory bowel diseases.
Viral hepatitis in children: state and prospects for solving the problem
Authors: Goriacheva L. G. , Ventslovayte N. D. , Greshnyakova V. A. 
Published: December 2021

The problem of viral hepatitis (VH) today is an acute problem for the world healthcare system. Along with the COVID-19 pandemic, the VH pandemic claims up to 1.5 million lives annually. Since 2016, the Russian Federation has launched a WHO program aimed at combating VH. One of the first steps on the path of global elimination is getting rid of the virus in the small groups, among which micro-elimination in the child population is one of the promising areas.This review is devoted to the current state of the problem of VH in children in the Russian Federation today. The success of vaccine prevention (against viral hepatitis A and B) made it possible to achieve results in the form of a significant decrease in the incidence of children, minimizing the risk of perinatal infection. However, in recent years, there has been a progressive decline in vaccination coverage. This is mainly due to the growing popularity of anti-vaccination lobbies, a decrease in the awareness of patients and health workers about the need for timely vaccination, as well as the introduction of restrictive measures to prevent a new coronavirus infection. The emergence of mutant, "vaccine-eluting" strains, which are also resistant to available antiviral drugs, is another serious problem on the way to eliminating viral HBV. In the field of treating children with HBV, the possibilities are extremely limited, only 2 drugs are available, one of which (tenofovir alafenamide) is available only from the age of 12. Registration of direct antiviral drugs for the treatment of adolescents with chronic hepatitis C has made it possible to bring closer the goal of microelimination of the virus in children. However, the high cost of drugs poses a challenge for the state to introduce long-term benefit programs to ensure the availability of treatment. In addition, at the moment, the treatment of young children in our country remains a prospect for the future.Thus, despite significant advances in the strategy for the elimination of viral hepatitis, a number of problems remain relevant and present significant difficulties in achieving the global goal.
Congenital herpes simpleх: modern approach to prevention, diagnosis, and treatment
Authors: Ivanova R. A. , Vasilyev V. V. , Rogozina N. V. , Grineva A. A. , Ushakova G. M. 
Published: December 2021

Among the classic pathogens of congenital infection, herpes simplex viruses type 1 and type 2 play important role. Neonatal herpes develops as a result of antenatal transmission of HSV. The greatest risk occurs with the primary infection of a woman in the late stages of pregnancy. In 85% of cases, genital and neonatal herpes is associated with HSV-2.The purpose of study: to identify the relationship between early manifestations of neonatal herpes and genital herpes during pregnancy for early diagnosis and etiological therapy of the newborn.Materials and methods. The analysis of current clinical recommendations and international consensuses of professional communities in Russia, the USA, and a number of European countries in the management of pregnant women was carried out. The five medical histories of newborn infants with a diagnosis of congenital herpetic infection were analyzed. In the clinical guidelines for the management of normal pregnancy, routine screening of pregnant women for HSV is omitted, however, examination is recommended for symptoms of genital herpes. For the prevention of neonatal herpes, antiviral drugs and caesarean section are used. Congenital herpes develops rarely, proceeds severely with significant residual manifestations in children. Antiviral therapy (Acyclovir) is used for herpetic infection in newborns: with systemic and local infection (eye damage). The analysis showed: despite the recurrent course of genital herpes in 4 out of 5 women during pregnancy, none of the pregnant women had a laboratory examination for HSV, pregnant women did not receive systemic etiological therapy and all deliveries were natural. The absence of preventive measures contributed to the early, during the first three days of life, the development of severe forms of neonatal herpes. In respect that the lack of significant clinical specificity and delayed manifestation, an antenatal anamnesis is important diagnostic criterion for neonatal herpes.
Pertussis and pertussis-like syndrome in young children
Authors: Babachenko I. V. , Tian N. S. , Nesterova Yu. V. 
Published: December 2021

The most common infectious diseases with a risk of severe, non-smooth course and unfavorable outcome in young children, including the first year of life, are pertussis and respiratory syncytial viral infection (RSV infection), often occurring with pertussis-like syndrome.Objective: to establish clinical and laboratory differential diagnostic criteria for pertussis and RSV infection in children of the first year of life.Materials and methods: A retrospective comparative study was conducted, which included patients of the first year of life (from 1 month to 11 months and 29 days), regardless of the duration of hospitalization and duration of the disease: 48 patients with pertussis and 26 with acute RSV infection.Results: The compared groups of patients were comparable in age, the number of severe forms (4.6 ± 0.5 months, 17% for pertussis and 4.0 ± 0.2 months, 16% for RS infection). The disease in both cases began subacute, however, with RSV infection 92% of children were hospitalized in the first 5 days from the onset of the disease, with pertussis — in the first week of the period of convulsive cough — 47.9%, in the second week — 41.7%, in the third week — 10.4%. 52% of patients with RSV infection had no fever or (in 32%) did not exceed 1—3 days. In 41.3% of patients it was subfebrile (37—38 °C), in 21.1% it was febrile (38—39 °C). In patients with pertussis the onset of the disease took place against the background of normal body temperature. In patients with RSV infection, bronchiolitis was recorded in 24% of cases, obstructive bronchitis — in 60%. Patients with pertussis, 89.6% of whom were not vaccinated and 10.4% did not complete the initial course of vaccination, had a typical paroxysmal cough with reprises. Complications in the form of respiratory rhythm disturbances were recorded in 14.6% of cases, pneumonia — in 6.3%. Comparison of hematological parameters revealed highly significant differences in the levels of leukocytosis and relative lymphocytosis (p < 0.001), as well as thrombocytosis (p < 0.01), with the predominance of all indicators in patients with pertussis.Conclusion. Differential diagnostic criteria for the similarity of the clinical picture may be established hematological differences: pronounced leukocytosis due to lymphocytosis, increasing in dynamics, and thrombocytosis in pertussis and normocytosis with moderate lymphocytosis, a possible tendency to thrombocytosis in severe RSV infection.
Cytokine status indicators in children with acute respiratory viral infections after treatment with intranasal interferon-based medicine
Authors: Afanasyeva O. I. , Golovacheva E. G. , Osidak L. V. , Timonina V. S. , Gonchar V. V. , Obraztsova E. V. , Dondurey E. A. , Goncharova E. S. , Simbirtsev A. S. , Lioznov D. A. 
Published: December 2021

Objective: to study the dynamics of local and systemic cytokine production in children with different clinical forms of acute respiratory viral infections (ARVI), including COVID-19, and to assess the effectiveness of local interferon-based therapy.Patients and methods: The study included 180 patients aged from 1 month to 17 years with сonfirmed acute respiratory viral infections (ARVI), including COVID-19. Patients were divided into 2 groups (main and control) of 90 people each. In the main group patients received the intranasal interferon-based medicine Grippferon® in addition to the basic therapy, the control group patients received only basic therapy. The cytokine status was assessed by the content of IFN-α and -γ, IL-1β, IL-8, IL-4, IL-10, IL-17 in blood serum and in nasopharyngeal secretions by enzyme immunoassay kits ("Cytokine", St. Petersburg).Results: Statistically significant differences were revealed in the systemic and local content of individual cytokines in ARVI of different etiologies, depending on the level of damage to the respiratory tract. The use of the interferon-based medicine Grippferon® for intranasal use in children in the early stages of ARVI, including COVID-19, helps to decrease the high content of cytokines IL-1β and IL-8 in the nasopharynx by reducing the viral load. As a result, the duration of catarrhal disease symptoms and intoxication was also significantly reduced as well as the pathogen elimination time.
Early neuroborreliosis in children, Bannwart syndrome (clinical observations)
Authors: Markova K. V. , Skripchenko E. Yu. , Skripchenko N. V. , Gorelik E. Yu. , Vilnits A. A. , Astapovа A. V. , Pulman N. F. 
Published: December 2021

The problem of ixodic tick-borne borreliosis remains relevant due to its ubiquity, high incidence, especially in the Northwestern Federal District, a variety of clinical manifestations, as well as the possibility of chronization, including in children.Purpose: to describe our own clinical observations of Bannwart syndrome, which developed during the dissemination of the pathogen.Results. Bannwart syndrome is pathognomonic for borreliosis symptoms, including a triad of clinical manifestations: serous meningitis, single- or bilateral lesion of facial nerves, polyneuropathy. Timely clinical and adequate laboratory diagnostics determine the favorable course of the disease.
A content analysis of change management strategies used in technological transitions in higher education institutions from the lens of a strategic alignment framework
Authors: Guerra-López Ingrid , EL Dallal Siba 
Published: December 2021

Technology innovations have the potential to significantly strengthen the ability of higher education institutions to deliver on their core educational mission with greater quality, efficiency, and effectiveness. Not surprisingly, managing technological changes is among the chief concerns for institutional leaders, and yet there is a dearth of research that provides concrete frameworks for managing this type of change in a higher education context. Using Guerra-López and Hicks’s Learning and Development Strategic Alignment (LDSA) framework, this qualitative study used a directed content analysis approach to develop a contextualized framework for planning and managing technology change in higher education institutions. The findings suggest that there is a meaningful fit between specific change management strategies found in the learning management systems (LMS) transition research literature and the LDSA framework. The various strategies were synthesized and grouped around LDSA dimensions and core functions, resulting in a technological change management framework contextualized for higher education.
Maturing of the human placenta, maturity of the utero-placental area and its diagnostics
Authors: A. V. Hoshovska  , V. M. Hoshovskyi  
Published: December 2021

Authors give histological criteria of maturity of the uteroplacental region at the separate intervals of gestation. The results of this investigation can be recommended for the diagnostics of preterm or retarded maturing of the human placenta as manifestation of afterbirth insufficiency.
Analysis of antenatal risk factors in multiple pregnancies
Authors: О. V. Kravchenko  
Published: December 2021

We examined 42 pregnant women with twins who gave birth in 2013 in the clinical maternity hospital № 2 of Chernivtsi. It was established that multiple pregnancy is more common in multipara women of age group 25-30 years (52,3 %). The course of pregnancy with twins is aggravated in 78,5 %, which is much higher than the average population index. Dichorionic diamniotic twins dominated (57,1 %) in the structure of multiple pregnancy. The preterm labor with dichorionic diamniotic twins occur 3 times less frequently (23,6 %) than in monochorionic diamniotic multiple pregnancies (75,4 %).
Production and reception of the growth factor in the placenta during the physiological pregnancy and the pregnancy, complicated with gestosis
Authors: O. A. Kuzmina  
Published: December 2021

30 women with physiological pregnancy and 28 women with gestosis were examined. In the early chorion obtained after abortion and on the full-term placenta the content of the epidermal growth factor (EGF), vascular-endothelial growth factor (VEGF) and their receptors were studied by means of the ELISA method. In the process of normal gestation the increase of the placental production both of the EGF and VEGF was found. During the pregnancy complicated with gestosis and miscarriage in the first trimester the content of EGF and its receptor was lower compared to the physiological values. For VEGF and its receptor opposite changes were found: the increase of quantity of the growth factor and the decrease of its receptor. In the case of gestosis and term pregnancy the content of the both growth factors and their receptors was lower than in controls. The revealed changes in production of the angiogenic growth factors and their receptors in the placenta may have the pathogenic importance in the development of gestosis.
Prevalence of stomatologic pathology in persons with Shegren's illness
Authors: I. K. Novitska  , A. I. Chelii  
Published: December 2021

The purpose of researches consisted in studying functional activity of salivary glands and prevalence of stomatologic pathology in persons with Shegren's illness. Results of researches showed that damage of salivary glands at Shegren's illness is accompanied by a decrease in functional activity of salivary glands. The increase in prevalence of caries and inflammatory diseases of the mucous membrane of an oral cavity has been revealed.
Pathogenetic substantiation to correct disorders of the blood plasma fibrinolytic system in patients with chronic diffuse liver diseases and disorders of thyroid homeostasis
Authors: Chympoy K. A. , Pashkovska N. V. , Fediv O. I. , Pavlibroda N. M. 
Published: December 2021

The dynamics of the indices of fibrinolysis and cellular adhesion in patients with chronic diffuse liver diseases against the ground of administration of “Triovit”, a selenium-containing drug, has been studied. The administration of “Triovit” in a comprehensive therapy of patients with chronic diffuse liver diseases was found to improve the indices of the blood plasma fibrinolytic system, to reduce adhesive cellular properties and to increase total enzymatic activity of the blood plasma.
Analysis of the quality of treatment and rehabilitation activities in patients with bronchoobstructive diseases and justification of modern approaches to their improvement
Authors: V. I. Shevchuk  , V. Y. Zaburianova  , M. V. Vernyhorodska  , I. A. Iliuk  , V. S. Vernyhorodskyi  
Published: December 2021

The main aspects of providing the patients and disabled people suffering from Chronical Obstructive Pulmonary Diseases (COPD) and asthma with medical and expert assistance by examining health expert documentation of patients in the Institute clinic in 2013 (48 people). Unsatisfactory organization of pulmonology care, poor quality of diagnosing and treatment, as well as imperfection in determining the vital activity of people with bronchoobstructive diseases were found. The methods for improving the quality of rehabilitation of patients and disabled as victims of COPD and asthma were suggested.