bluuebunny/crossref_metadata_2025_split huggingface dataset:
Super Vision: Dream or Reality
Authors: Arbelaez Maria C 
Published: April 2021

ABSTRACT
PURPOSE: To present and evaluate the early clinical experience of laser in situ keratomileusis (LASIK) using the custom guided corneal ablation system by NTOEK, which includes an OPD-Scan, Final Fit program, and Nidek Multipoint EC-5000 excimer laser.
METHODS: The OPD-Scan diagnostic system containing a scanning slit refractometer using skiascopic technology with simultaneous Placido disc corneal topography is described. The Final Fit program that converts the refractive error and topography data into custom algorithms to couple with the Nidek EC-5000 Multipoint excimer laser is explained. Thirty-eight cases of LASK using the Nidek MK-2000 microkeratome and the Nidek Multipoint excimer laser with custom and conventional treatments are presented. Eyes were divided into two groups: LASIK custom group and LASDX conventional group.
RESULTS: Predictability and attempted correction were similar in both groups. One month after surgery, all eyes were between ±1 line of visual acuity. In the custom LASK group there was a gain of one line in 50% and two lines of visual acuity in 25% of patients at 1 month after surgery. In the conventional LASDX group there was no gain of lines of visual acuity at 1 month. In the comparative group (one eye custom LASDX and the other eye conventional LASIK) there was data available for six patients (75%). At one month, all patients preferred the vision in their custom LASDX-treated eye.
CONCLUSION: The Nidek LASDX custom and conventional treatments were safe and predictable. There was more accuracy, better visual acuity, and more subjective satisfaction in the custom LASDX custom treatment group. [J Refract Surg 2001; 17(suppl):S211-S218]
Laser in situ Keratomileusis vs. Laser Epithelial Keratomileusis (LASIK vs. LASEK)
Authors: Scerrati Ermanno 
Published: April 2021

ABSTRACT
PURPOSE: To compare results of laser in situ keratomileusis (LASIK) and laser epithelial keratomileusis (LASEK) for the treatment of myopia.
METHODS: Two groups of fifteen patients (30 eyes) each were assigned to either the LASLK group or the LASEK group. LASLK procedure: A Hansatome microkeratome with the ring at 9.5 mm was used to create the corneal flap (depth, 160 µm). The myopic correction was then registered on the Nidek EC-5000 excimer laser and the appropriate ablation performed. LASEK procedure: Twenty percent ethyl alcohol was placed within the corneal epithelial ring. An intact epithelial flap was retracted. The Nidek EC-5000 excimer laser was applied in a similar manner to the LASLK procedure. Patients from both groups were followed postoperatively for 6 months, measuring best spectacle-corrected visual acuity, contrast sensitivity, and corneal topographic meridians of 3 mm, 5 mm, and 7 mm.
RESULTS: Comparing corneal topography, best spectacle-corrected visual acuity, and contrast sensitivity data, refractive results in the LASEK group were better than the LASLK group.
CONCLUSION: Objective data show that with the Nidek EC-5000 excimer laser, the LASEK method of corneal splitting may prove superior to the LASLK method. [J Refract Surg 2001;17(suppl): S219-S221]
Effectiveness of Laser in situ Keratomileusis With the Nidek EC-5000 Excimer Laser for Pediatric Correction of Spherical Anisometropia
Authors: Rybintseva Ludmila V , Sheludchenko Viatcheslav M 
Published: April 2021

ABSTRACT
PURPOSE: To determine the effectiveness of laser in situ keratomileusis (LASLK) for correction of spherical anisometropia in patients under 18 years of age.
METHODS: Thirty-eight patients (58 eyes) with myopic spherical anisometropia and spherical antimetropia were treated. Group 1 included 31 eyes of 20 children (9 to 15 yr) and Group 2 included 27 eyes of 18 children under 18 years old (16 to 17 yr). The difference in refraction between the two eyes in Group 1 was an average 5.95 D and in Group 2, 6.92 D. The operations were performed with the Nidek EC-5000 eximer laser and the Hansatome Chiron Vision HT-230 microkeratome. The procedure was performed under local anesthesia. Patients were followed for 18 months. Occlusion therapy was started 2 weeks postoperatively and continued for 3 to 4 months. Ten patients suffered from strabismus; they received orthoptic therapy.
RESULTS: Uncorrected visual acuity (UCVA) and best spectacle-corrected visual acuity (BSCVA) improved after LASLK. The difference in refraction between the two eyes was reduced as was the angle of strabismus. Binocular vision improved in one patient and simultaneous vision improved in three patients (vision in these patients was monocular before treatment).
CONCLUSIONS: LASLK with the Nidek EC-5000 excimer laser and the Hansatome Chiron Vision HT-230 microkeratome, together with occlusion and orthoptic therapy for pediatric correction of spherical anisometropia, may be an effective procedure that facilitates increased visual acuity and improved binocular vision. LASLK appears to be a safe surgical procedure for children over 9 years of age. [J Refract Surg 2001;17(suppl):S224-S228]
The Nidek MK-2000 Microkeratome System
Authors: Schumer D James , Bains Harkaran S 
Published: April 2021

ABSTRACT
PURPOSE: To assess flap thickness and the performance of the Nidek MK-2000 microkeratome during laser in situ keratomileusis (LASBK).
METHODS: Three hundred seventy consecutive eyes of patients undergoing LASIE had the depth of flaps measured via subtractive pachymetry. All flaps were created using two different model numbers of the Nidek MK-2000 microkeratome. Both 130-/tm and 160-/nn depth plates were evaluated. Microkeratome-induced complications were also recorded.
RESULTS: Buttonhole ñaps and free flaps were not seen in this study. One short flap occurred and suction could not be obtained in two eyes. The mean flap thickness obtained using the 130-µm depth plate for model number 121 was 129 ± 21.8 µm. The mean flap thickness obtained using the 160-µm depth plate for model number 121 was 150 ± 29.6 µm. The mean flap thickness obtained using the 130-µm depth plate for model number 65 was 152 ± 25 µm. The mean flap thickness obtained using the 160-µm depth plate for model number 65 was 173 ±26.9 µm.
CONCLUSION: The Nidek MK-2000 microkeratome is safe and creates flaps of predictable thickness. [J Refract Surg 2001;17(suppl):S250-S251]
Visual Rehabilitation With Contact Lenses After Laser in situ Keratomileusis
Authors: Ward Michael A 
Published: April 2021

ABSTRACT
PURPOSE: Laser in situ keratomileusis (LASIK) has become the surgical treatment of choice for moderate myopia and is in widespread use globally. Visual potential is sometimes limited due to irregular corneal topography following surgery.
METHODS: A retrospective chart review of 35 eyes of 22 patients requiring visual rehabilitation following LASIK was performed. Four contact lens designs were used and evaluated for appropriate cornea-contact lens fitting relationship.
RESULTS: Mean best contact lens-corrected visual acuity of 20/25 was significantly better than best spectacle-corrected visual acuity of 20/40. The average time from surgery to contact lens fitting was 8 months, with almost half (10/22) being fitted at 4 months. An aspheric design with 0.17 mm of axial edge lift was used most commonly. Lens diameters ranged from 9.2 to 10.9 mm, with a mean diameter of 10.2 nun. The contact lens base curve to cornea relationship would suggest an initial base curve selection to be approximately 2.1 D steeper than the mean postoperative keratometric power.
CONCLUSIONS: Rigid gas permeable contact lenses can improve visual function in patients with irregular corneal topography after LASIK!. [J Refract Surg 2001;17:433-440]
Reversal of Myopic Anisometropic Amblyopia With Phakic Intraocular Lens Implantation
Authors: Chipont Enrique M , García-Hermosa Pedro , Alió Jorge L 
Published: April 2021

ABSTRACT
PURPOSE: To report a case of reversal of myopic anisometropia amblyopia with phakic intraocular lens implantation.
METHODS: A 6-year-old boy with anisometropic amblyopia with spherical equivalent refraction of right eye: -14.00 -3.00 x 100°, left eye: -0.50 -3.25 x 90°, was treated for 2 years with occlusion to the left eye, with poor results. Refractive surgery was planned because of contact lens intolerance at age 8 years. A -15.00-D iris claw Artisan intraocular lens (IOL) was implanted.
RESULTS: Following surgery, treatment of the amblyopia and spectacle correction of -4.00 D cylinder at 85° in the right eye and -3.50 D cylinder at 90° in the left eye was necessary. Visual acuity ? months after surgery was 20/25 in the right eye and 20/20 in the left eye, and has remained stable 18 months after surgery.
CONCLUSION: Myopic anisometropic amblyopia in an 8-year-old boy was treated successfully with implantation of an Artisan iris claw phakic anterior chamber IOL, combined with occlusion therapy, and resulted in reversal of amblyopia. [J Refract Surg 2001;17:460-462]
Photorefractive Keratectomy for Hyperopia in 800 Eyes With the Meditec MEL 60 Laser
Authors: Nagy Zoltán Z , Krueger Ronald R , Hamberg-Nyström Helen , Füst Agnes , Kovács Andrea , Kelemen Edit , Süveges Ildikó 
Published: April 2021

ABSTRACT
PURPOSE: To evaluate the refractive results of 800 hyperopic eyes undergoing PRK treatment.
METHODS: Eight hundred hyperopic eyes were treated with PRK. An Aesculap-Meditec MEL 60 scanning ArF excimer laser used. Treatment Group 1 consisted of eyes with a preoperative refractive error of +3.50 D or less (n = 482) and Group 2, of +3.75 D or more (n = 318).
RESULTS: Preoperatively, Group 1 required an average correction of +2.88 ± 1.34 D and Group 2 required +5.64 ± 2.96 D. One year after PRK, average residual correction was +1.26 ± 1.24 D in Group 1, and in Group 2, +2.46 ± 1.84 D. In Group 1, uncorrected visual acuity (UCVA) was 20/40 or better in 88.4% (426/482); 20/20 or better in 75.7% (365); 2.1% (10/482) of eyes lost 2 lines, 2.1% (10/482) gained 2 lines; 3.1% (15/482) gained 2 or more lines of BSCVA; 74.4% (359/482) of eyes were within ±0.50 D of target correction and 84.8% (408/482) were within ±1.00 D. In Group 2, 47.57< (151/318) had UCVA of 20/40 or better; 34.2% (109/318) saw 20/20 or better uncorrected; 19.1% (61/318) lost 2 lines; 11.6% (37/318) lost 3 lines; none of the eyes gained 2 or more lines of BSCVA; 22.3% (71/318) were within ±0.50 D and 46.80Í (149/318) were within ±1.00 D of target correction. Refractive stability was achieved after 6 months; a slight regression after 6 months was still observed. In Group 1, 10.5% (42/482) and in Group 2, 21.6% (69/318) complained of problems with daytime vision (glare and ghost image); during night-driving in Group 1, 17.6C7( (85/482) and in Group 2, 40.5% (129/318) had problems.
CONCLUSION: PRK with the Aesculap-Meditec MEL 60 scanning ArF excimer laser offered the best long-term results with +3.50 D or less preoperative refractive error. With higher corrections, regression, decrease in BSCVA, and daytime visual problems were encountered. [J Refract Surg 2001; 17:525-533]
Effect of Hyaluronic Acid on Corneal Haze in a Photorefractive Keratectomy Experimental Model
Authors: Gómez Silvia , Herreras José M , Merayo Jesús , García Margarita , Argüeso Pablo , Cuevas Juan 
Published: April 2021

ABSTRACT
PURPOSE: To evaluate the ability of topical hyaluronic acid to decrease corneal opacity after excimer laser photorefractive keratectomy (PRK) in hens.
METHODS: Twenty-four white hens underwent bilateral 193-nm excimer laser PRK to correct -9.00 D of myopia. One eye received postoperative treatment with topical 1% hyaluronic acid six times daily for 3 days; the other eye received phosphate buffered saline. Slit-lamp evaluation by a masked observer was performed for 6 months after PRK, and electron microscopy was carried out at the end of the study.
RESULTS: There were no significant differences in postoperative haze between the eyes treated with hyaluronic acid and those treated with phosphate buffered saline.
CONCLUSION: Topical administration of hyaluronic acid had no effect on the development of corneal haze following PRK in hens. [J Refract Surg 2001;17:549-554]
Influence of Corneal Curvature on Calculation of Ablation Patterns Used in Photorefractive Laser Surgery
Authors: Mrochen Michael , Seiler Theo 
Published: April 2021

ABSTRACT
PURPOSE: The aim of this work was to clarify the influence of the effective illumination area and possible reflection losses that occur during lasertissue interaction on the modeling of profiles for customized corneal ablation, such as wavefrontguided treatments.
METHODS: The changes of the ablation depth per laser pulse due to the projection of a laser spot onto the corneal front surface and reflection losses at the air-tissue interface were calculated.
RESULTS: Moving with a scanning-spot from the center of the cornea toward the limbus resulted in an increase of the effective illumination area and reflection losses, which led to a decrease in the ablation depth per laser pulse. The decrease of the ablation depth was strongly related to the initial radiant exposure and the corneal curvature radius.
CONCLUSIONS: The corneal front surface must be taken into consideration for ablation profile calculations, especially in customized treatments, due to the strong dependence of the ablation depth on the corneal curvature. [J Refract Surg 2001; 17: S584-S587]
Wavefront-supported Photorefractive Keratectomy: 12-month Follow-up
Authors: Dausch Dieter , Dausch Sabine , Schröder Eckhard 
Published: April 2021

ABSTRACT
PURPOSE: To evaluate safety, efficacy, predictability, and stability of wavefront-supported photorefractive keratectomy (PRK) for correction of myopia and myopic astigmatism, with 12-month follow-up.
METHODS: Thirty eyes of 23 patients with myopia less than -8.00 D (mean -3.76 ± 1.90 D) and cylinder less than -3.50 D (mean -0.81 ± 0.71 D) were selected. Aberrometry measurements were taken with the Asclepion aberrometer in order to perform customized wavefront-supported PRK. Eyes were treated with the Asclepion MEL 70 excimer laser and were followed for 12 months.
RESULTS: UCVA of 20/16 or better was achieved by 47% (14 eyes) at 1 month, 67% (20 eyes) at 3 months, 77% (23 eyes) at 6 months, 90% (27 eyes) at 9 months, and 83% (25 eyes) after 1 year. No eye lost more than 1 line of BSCVA at 3, 6, 9, or 12 months. Two eyes (7%) gained more than 2 lines 1 month postoperatively, and 13% (4 eyes) gained more than 2 lines at 6, 9, and 12 months postoperatively. BSCVA of 20/10 or better was achieved in nine eyes (30%) at 1 and 12 months. Visual acuity under low contrast at 3 and 12 months after PRK was unchanged in 87% (26 eyes). Visual acuity under glare remained unchanged at 3 months after PRK in 86% (26 eyes) and at 12 months in 83% (25 eyes).
CONCLUSION: Excimer laser wavefrontsupported PRK with the Asclepion MEL 70 laser was safe and effective for the treatment of myopia and myopic astigmatism. Daylight visual acuity and mesopic visual acuity outcomes remained stable over 1 year. [J Refract Surg 2003;19:405-411]
Laser in situ Keratomileusis for Correction of Induced Astigmatism From Cataract Surgery
Authors: Norouzi Hamid , Rahmati-Kamel Mohsen 
Published: April 2021

ABSTRACT
PURPOSE: To evaluate the efficacy, predictability, stability, and safety of laser in situ keratomileusis (LASIK) to correct residual astigmatism after cataract surgery.
METHODS: LASIK was performed on 20 eyes of 20 patients with refractive myopic or mixed astigmatism (3.00 to 6.00 D) at least 1 year after extracapsular cataract extraction with posterior chamber intraocular lens implantation without complication. Each eye received bitoric LASIK with the Nidek EC-5000 excimer laser and the Automated Corneal Shaper microkeratome.
RESULTS: At 6 months after LASIK, mean refractive cylinder decreased from 4.64*0.63 D to 0.44±0.24 D (P<.001). Mean percent reduction of astigmatism was 90.4*5.0% (range 80% to 100%). Mean spherical equivalent refraction decreased from -2.19±0.88 D (range -1.00 to -3.88 D) to -0.32±0.34 D (range -1.25 to +0.38 D) (P<.001). Vector analysis showed that the mean amount of axis deviation was 0.7±1.2° (range 0° to 4.3°) and the mean percent correction of preoperative astigmatism was 92.1*5.9% (range 85.6% to 108%). Eighty-five percent of all eyes had a mean spherical equivalent refraction and mean cylinder within ±0.50 D of emmetropia. Change in spherical equivalent refraction and cylinder from 2 weeks to 6 months was =S0.50 D in 90% (18 eyes) and 95% (19 eyes), respectively. Spectacle-corrected visual acuity was not reduced in any eye. Diffuse lamellar keratitis occurred in three eyes (15%) after LASIK, and were treated successfully with eyedrops.
CONCLUSION: LASIK was an effective, predictable, stable, and safe procedure for correction of residual myopic or mixed astigmatism ranging from 3.00 to 6.00 D with a low spherical component after cataract surgery. [J Refract Surg 2003;19: 416-424]
The Duet-Kelman Lens: A New Exchangeable Angle-supported Phakic Intraocular Lens
Authors: Alió Jorge L , Kelman Charles 
Published: April 2021

ABSTRACT
PURPOSE: We describe a new model of anglesupported phakic intraocular lens, the DuetKelman lens, the design of which incorporates two separate supporting parts. The haptic and the optic are separately implanted and then fixed together inside the eye. The lens allows optic or haptic exchange depending on the anatomical, refractive, and visual outcome of the patient. Results of the initial pilot study are presented.
METHODS: Three patients (three eyes) were implanted with the Duet-Kelman lens and were followed for a minimum of 6 months. Surgery was performed under topical anesthesia.
RESULTS: Surgery was feasible through a 2.5 -mm incision, without complications. Refractive and visual results were stable in all eyes. Haptic exchange was done in one eye that developed pupil ovalization.
CONCLUSION: In this pilot study of three eyes, the Duet-Kelman phakic intraocular lens offered small incision size and potential exchange of the haptic or the optic. [J Refract Surg 2003;19:488-495]
Topography-guided Laser in situ Keratomileusis (TOPOLINK) to Correct Irregular Astigmatism After Previous Refractive Surgery
Authors: Alió Jorge L , Belda Jose I , Osman Amr A , Shalaby Ahmad M M 
Published: April 2021

ABSTRACT
PURPOSE: To assess whether topography-driven laser in situ keratomileusis (LASIK) can correct induced corneal irregular astigmatism.
METHODS: A prospective non-comparative case series of 41 eyes (38 patients) with irregular astigmatism following corneal refractive surgery, included two groups: Group 1 (26 eyes) with a defined topographic pattern and Group 2 (15 eyes) with no pattern. Ablation was performed using the Technolas 217C excimer laser with a software ablation program (TOPOLINK) based on corneal topography. Uncorrected and best spectacle-corrected visual acuity, manifest and cycloplegic refraction, corneal topography, superficial corneal surface quality, and image distortion were measured.
RESULTS: At 6 months follow-up in Group 1 eyes (defined topographic pattern) mean preoperative BSCVA improved from 0.16 ± 0.11 LogMAR (0.4 to 0) to 0.09 ± 0.10 LogMAR (0.2 to 0) (P=.001) (safety index of 1.1). In Group 2 eyes (no pattern), mean preoperative BSCVA was 0.18 ± 0.11 LogMAR (0.4 to 0), similar to the postoperative BSCVA of 0.17 ± 0.10 LogMAR (0.3 to 0) (safety index of 0.98). Mean postoperative UCVA was 3*0.3 LogMAR in 25 eyes (96.2%) in Group 1 (efficacy index of 0.8) and 7 eyes (46.6%) in Group 2 (efficacy index of 0.5). Both superficial corneal surface quality and image distortion significantly improved in Group 1; there were no significant changes in Group 2. We reoperated nine eyes (21.9%).
CONCLUSIONS: Topographic-assisted LASIK was helpful in selected cases where irregular astigmatism showed a pattern. It was ineffective in undefined irregular astigmatism. Partial correction of the irregularity and regression of the obtained effect was common. [J Refract Surg 2003;19:516-527]
Nomogram Considerations With the Technolas 217A for Treatment of Myopia
Authors: Anderson Nicole J , Hardten David R , Davis Elizabeth A , Schneider Timothy L , Samuelson Thomas W , Lindstrom Richard L 
Published: April 2021

ABSTRACT
PURPOSE: To determine whether surgeonspecific nomogram adjustments are useful when using the Technolas 217Aexcimer laser for treating myopia and myopic astigmatism.
METHODS: We conducted a prospective evaluation of 216 consecutive eyes with 6 months followup after treatment of myopia or myopic astigmatism with the Technolas 217A laser. Attempted vs. achieved change in refraction was analyzed with a statistical analysis software program. Factors such as age, corneal thickness (pachymetry), preoperative spherical equivalent refraction, preoperative cylinder, and optical zone were studied to evaluate their role in predicting refractive outcome at 6 months after LASIK.
RESULTS: The mean value of attempted spherical equivalent refraction was -5.32 ± 2.72 D. The mean achieved refractive correction at 6 months was -5.55 ± 2.78 D, with a mean spherical equivalent of 0.13 ± 0.54 D. The percent achieved effect at 1 month was 105%, and at 6 months, 103%. Preoperative spherical equivalent refraction and optical zone size were strong predictors of 6-month LASIK outcome. There was a 9% difference in the percent achieved effect between a 4 and 7-mm optical zone. There was no correlation between age, preoperative cylinder, or surgeon and 6-month outcome.
CONCLUSIONS: Surgeons using the planoscan software on the Technolas 21 7A may experience a small initial overcorrection. There may be a benefit to reducing the treatment given with larger optical zones and smaller corrections. [J Refract Surg 2003; 19:654-660]
First 100 CustomCornea Commercial Eyes
Authors: Durrie Daniel S 
Published: April 2021

ABSTRACT
PURPOSE: With the advent of wavefront-guided custom abalation we not only try to reach a target of 20/20 vision, but strive for improvement in what has always been most important - the quality of this vision.
METHODS AND RESULTS: Insights are presented, based on clinical experience at Durrie Vision with our first 100 commercial CustomCornea eyes. We highlight key points for preparing a clinical practice for this new technology, such as staff training, marketing, and pricing. We discuss technical aspects such as patient selection and target adjustment as they relate to the Alcon LADARWave system.
CONCLUSION: In our practice we have thus far had clinical success with CustomCornea; patient acceptance has been high, and by closely monitoring our first few patients we were able to reduce the number of future enhancements. [J Refract Surg 2003;19:S687-S690]
Effect of Antineoplastic Drugs on Cell Proliferation - Individually and in Combination
Authors: Litin Bradley S , Kwong Erna M , Jones Mark A , Herschler Jonathan 
Published: April 2021

ABSTRACT
Three antineoplastic agents, bleomycin, cytosine arabinoside and 5-fluorouracil, were studied individually and in combination to determine their effectiveness in controlling cell growth in the presence of fetal bovine serum. All three drugs were effective individually in specifically controlling proliferation (as measured by 3H-thymidine uptake) of human Tenons capsule fibroblasts while bleomycin is effective at the lowest concentration. However, bleomycin alone rather than in combination with cytosine arabinoside or 5-fluorouracil was most effective in preventing division by these fibroblasts.
Scleral Reinforcement for High Myopia
Authors: Thompson Frank B 
Published: April 2021

ABSTRACT
This paper reviews the scleral reinforcement procedure for high myopia. A discussion of the indications and operative technique is presented with postoperative results and complications in 191 cases performed by one surgeon over the last 14 years. A discussion of the history of scleral reinforcement, modification of technique, and pathogenesis of high myopia is presented.