bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genèse d’une réflexion sur les sensibilités collectives des années 60 au regard du succès du Dernier des Justes
Authors: Marcovich Malka 
Published: April 2021

Le 16 novembre 1959, le prix Goncourt est décerné à André Schwarz-Bart, écrivain apparu soudainement sur la scène médiatique depuis début septembre pour son roman Le Dernier des justes. Cette épopée que d’aucuns compareront à La Légende des siècles de Victor Hugo retrace les errances et persécutions d’une lignée de « Justes » depuis le xiie siècle jusqu’à 1943 au seuil de la chambre à gaz. Véritable bombe dans le paysage médiatique de l’époque, ce fut aussi un moment de curée inouïe. Cette fulgurance littéraire cristallise un ensemble d’événements dont nous sommes aujourd’hui les héritiers. Dans cette période de bascule des Trente Glorieuses se sont structurées des lignes de force identitaires et idéologiques qui n’ont jamais cessé de faire débat jusqu’à nos jours.
Evaluation of high-dose aspirin elimination in the treatment of Kawasaki disease in the incidence of coronary artery aneurysm
Authors: Sanati Farima , Bagheri Mohammadmehdi , Eslami Shahryar , Khalooei Ali 
Published: April 2021

Background:
Standard first-step therapy for Kawasaki disease consists of Intravenous immunoglobulin and high dose Aspirin (80-100 mg/kg/day). The standard dose of Intravenous immunoglobulin (2gr/kg) is strongly effective in reducing the risk of coronary arteries abnormalities. So, the proper dose and efficacy of Aspirin to decrease the risk of coronary arteries abnormalities is a controversial issue. In this study, it is tried to assess the result of eliminating high-dose Aspirin in the treatment of the acute phase of Kawasaki and observe the incidence rate of coronary arteries abnormalities when only Intravenous immunoglobulin was administered.

Methods:
This study is a prospective randomized, open-label, blinded end-points clinical trial performed in Afzalipour hospital in Kerman University of Medical Sciences from September 2017 to September 2018 in 62 patients with typical and atypical Kawasaki disease. The study group received Intravenous immunoglobulin (2 g/kg) and the control group get the same dose of Intravenous immunoglobulin plus Aspirin with the dose of 80-100 mg/Kg/day until they were afebrile for 48 hours. Afterward, both groups received a daily single dose (3-5 mg/kg) of Aspirin for six weeks. Echocardiography was done after two weeks, six weeks, and six months. Internal diameter of the left and right main coronary arteries was measured and then the corresponding Z-score was calculated.

Results:
In the study group, coronary arteries abnormalities decreased from 38.7% in the 2nd week to 16.1% in the 6th month. In the control group, it declined from 54.8% to 22.6%. There was no statistically significant difference between the groups in term of frequency of abnormal coronary arteries at the study period (P=0.151).

Conclusions:
We concluded that high dose Aspirin does not have a significant role in preventing coronary arteries abnormalities in Kawasaki disease and giving standard 2 gr/kg/day Intravenous immunoglobulin without high-dose Aspirin in acute-phases therapy does not increase the risk of coronary arteries abnormality.
A Randomized Control Trial on Comparative Effect of Scalp Nerve Block Using Levobupivacaine Versus Fentanyl on the Attenuation of Pain and Hemodynamic Response to Pin Fixation
Authors: Altaf Irfan , Banday Jahanara , Naaz Shagufta , Ozair Erum , Punetha Pankaj , Challam Kolli S. 
Published: April 2021

Abstract

Background:
The application of head fixation device and tightening of the pins on the scalp acts as an intense noxious stimulus with an increased hemodynamic response. We aimed at comparing the efficacy of scalp nerve block (SNB) using levobupivacaine against intravenous fentanyl bolus dose followed by continuous intravenous infusion for attenuation of pain and hemodynamic response to pin fixation.

Methods:
One hundred and eight patients undergoing elective supratentorial craniotomy under general anesthesia were randomly allocated to two groups: Group F received a bolus of intravenous fentanyl (2 μg/kg) followed by continuous maintenance infusion and Group S, in which a bilateral SNB was performed with 20 ml of 0.5% levobupivacaine. Hemodynamic variables and pain scores were the primary outcomes noted. Intraoperative isoflurane and additional fentanyl requirements, emergence time and any side effects were also recorded.

Results:
The variation in hemodynamics in terms of heart rate (per minute) at pin fixation (Group F [95.88 ± 7.79] and Group S [89.02 ± 5.42]) was significant (P < 0.001). There was a significant change in mean arterial blood pressure (mm Hg) between the groups at pin fixation Group F (104.70 ± 9.18) and Group S (92.88 ± 6.92) (P < 0.001). A significant reduction in pain and intraoperative fentanyl requirements was also seen. Emergence from anesthesia was significantly longer in Group F as compared to Group S (P < 0.001). No group had any significant complication.

Conclusion:
SNB is a reasonably safe and effective means for smooth control over hemodynamics and lesser intraoperative analgesic requirements compared to the fentanyl infusion in adult patients undergoing supratentorial craniotomies.
Thyroid Storm in Pregnancy
Authors: Hartawan I Gusti Agung Gede Utara , Senapathi Tjokorda Gde Agung , Ryalino Christopher , Pradhana Adinda Putra , Irawan Andi , Imannudin Rachmat 
Published: April 2021

Abstract
Endocrine emergencies can occur during pregnancy and are associated with the thyroid gland and diabetes. Thyrotoxicosis is a hypermetabolic condition associated with an increase in thyroid hormone in the blood. The manifestations of thyrotoxicosis can range from those without symptoms to a life-threatening condition such as thyroid storm. The diagnosis of thyroid storm can be made based on a history of previous thyroid gland disorders; current signs and symptoms; and laboratory tests of thyroid-stimulating hormone, free thyroxine, and triiodothyronine. The thyroid storm is a rare condition, but the mortality rate on these patients is high. Characteristics of thyroid storms are altered consciousness, hyperpyrexia, tachycardia, and gastrointestinal disturbances. Thyroid storm management focuses on the prevention of thyroid hormone synthesis and its conversion in the periphery, identification, and intervention of the thyroid storm causes and the management of systemic disorders that present during thyroid storm. We present a 24-year-old female who presented with a very high suspicion of thyroid storm based on her Burch and Wartofsky's score criteria had a total score with a very high suspicion of thyroid storm. While pregnancy itself can increase the risk of developing severe thyrotoxicosis, the main management is determined by the presence of emergency manifestations. Our concern was not only for the safety of the mother but also for the fetus. Some drugs need special attention because they cross the blood–placental barrier. Previous patient comorbidities should also receive attention in the management of thyroid storm. The patient was being treated in the intensive care unit and managed to move to a regular ward after 3 days.
Severe Hypotension During Vertebral Derotation in Surgical Correction of Scoliosis
Authors: Sutawan Ida Bagus Krisna Jaya , Suarjaya Putu Pramana , Lie Sanfred , Ryalino Christopher , Pradhana Adinda Putra 
Published: April 2021

Abstract
Hypotension event in intraoperative settings may cause postoperative morbidity in surgical correction of scoliosis. Most often complications of intraoperative hypotension are postoperative ischemic optic neuropathy and postoperative ischemic stroke due to global hypoperfusion. Hypovolemic shock due to bleeding or blood loss is the most common cause of intraoperative hypotension in surgical correction of scoliosis. However, bleeding is not only the main cause of hypotension. A young female underwent surgical correction of scoliosis, during the operation she had a sudden and rapid decrease of blood pressure (BP) but then rapidly improved after the surgeon stopped the surgery which was a de-rotational procedure. Neurogenic shock is one of the complications that may occur during the manipulation of the spinal cord which is marked by a sudden and rapid decrease of BP and usually accompanied by bradycardia due to sudden and rapid loss of autonomic tone. Hypotension in neurogenic shock usually is refractory hypotension which cannot be treated only with fluid resuscitation but also needs vasopressor, thus this neurogenic shock should get immediate and prompt treatment to avoid further complications.
Comparison of C-Reactive Protein Levels, Neutrophil Count, and Clinical Outcomes between Low-Dose Ketamine Given at the End of Surgery and at Induction in Laparotomy
Authors: Widnyana I Made Gede , Suarjaya I Putu Pramana , Senapathi Tjokorda Gde Agung , Ryalino Christopher , Adi Made Septyana Parama 
Published: April 2021

Abstract

Background:
Both surgery and anesthesia can cause an inflammatory response, rise in C-reactive protein (CRP) levels in response to the acute phase, as well as the activation and increased number of neutrophils. Ketamine with the right time of administration is expected to control the inflammatory response so that it can reduce the risk of postoperative complications such as pain and reduce the use of opioids.

Patients and Methods:
A total of 68 patients with physical status American Society of Anesthesiologists (ASA) I–II who underwent elective laparotomy were collected by consecutive sampling. The samples were divided into 2 groups; Group A received a low dose of ketamine at the end of the surgery, and Group B received a low dose of ketamine at the time of anesthesia induction. We measured CRP level, neutrophil count, visual analog scale (VAS), as well as total morphine consumption at 24 h postoperatively.

Results:
The increase in CRP levels in Group A was significantly lower compared to Group B (70.8 ± 42.7 vs. 115.0 ± 44.0 mg/L, P = 0.001). Group A has a significantly lower increase in CRP levels, VAS, and the total consumption of morphine 24 h postoperatively (P < 0.05). There was a strong positive between CRP and VAS (R = 0.702, P = 0.001).

Conclusion:
Administration of low doses of ketamine at the end of surgery was more effective in suppressing CRP levels, resulting in lower VAS score, and lower total morphine consumption in the 24-h postoperative period compared to low-dose ketamine given at the time of induction.
Publication Outcomes after Conference Abstract Submissions in a Singapore Anesthesiology Academic Clinical Program
Authors: Truong Ha Thi Thu , Goy Raymond Wee Lip , Sultana Rehena , Koh Darren Liang Khai , Singh Prit Anand , Siow Yew Nam , Soh Chai Rick , Sng Ban Leong 
Published: April 2021

Abstract

Background:
We conducted a survey among anesthesiologists in a Singapore Anesthesiology Academic Clinical Program to investigate the rate of successful publications following conference abstract submissions, the reasons for not submitting manuscripts, and unsuccessful publications.

Materials and Methods:
Anonymous online survey enquired about respondents' publication records, the number of abstracts submitted and accepted, the number of manuscripts written and their status in the past 3 years, the reasons for not submitting manuscripts following abstract submission, unsuccessful publications, and the types of published articles. Statistical analyses included the descriptive statistics and comparisons between two subgroups of clinician (Senior Resident/Associate Consultant [SRAC], Consultant [C]).

Results:
There were 68 responses to the survey. A total of 175 local and international conferences abstract submissions were accepted from May 2016 to May 2019. Of these, 67 (38.3%) were written into full-length manuscripts and 64 (36.5%) were published. The top reasons for the lack of manuscripts were “the low likelihood to be accepted for the publication due to methodological reasons,” “no intention to write the abstracts to manuscripts,” and “lack of time to prepare manuscripts.” The most common categories of published articles were case report/case series, retrospective, and prospective studies. The SRAC group (n = 41) reported higher number of retrospective studies than the C group (n = 27): 14 versus 3 studies, P = 0.045. Clinical research and medical education were the main successful publication domains.

Conclusion:
A minority of 36.5% (N = 65) of the abstracts submitted to conferences were published. This study identified potential areas where support can be given to anesthesiologists to improve publication success.
Methaemoglobinemia in Pregnancy
Authors: Boorugu Hari Kishan , Rane Makarand Anil , Usha G , Vadlamani Hemamalini , Madapu Manokanth , Gala Anisha 
Published: April 2021

Background:
Methaemoglobinemia is a rare disease complicating pregnancy and often diagnosed for the first time in perioperative or peripartum setting.

Aim:
To analyse the type of methaemoglobinemia, clinical presentation and pregnancy outcomes in our series of pregnant women with methaemoglobinemia.

Methods:
This is a single centre retrospective study of patients with methaemoglobinemia admitted between 2003 and 2015.

Results:
We had six pregnant women with methaemoglobinemia during the study period. Three women had congenital methaemoglobinemia and three of them had acquired methaemoglobinemia. Obstetric and foetal outcomes were good.

Conclusion:
Congenital methaemoglobinemia is reasonably well tolerated in pregnancy. With proper counselling, follow-up, avoidance of drugs associated with methaemoglobinemia and prompt diagnosis and management especially in cases of acquired methaemoglobinemia, we can achieve good pregnancy outcomes.
Conversion of Labour Epidural Analgesia to Anaesthesia for Emergency Caesarean Section
Authors: Pandya Sunil Thakorbhai , Mikkilineni Jyotsna , Madapu Manokanth 
Published: April 2021

Aim:
to determine the rates of failed conversion of EA to surgical anaesthesia for patient and clinician information and benchmarking, and to develop an algorithmic approach for safe conversion of EA. Materials and

Methods:
A retrospective audit of parturients who had labour epidural analgesia (EA) at an advanced tertiary care institute for women and newborn health in south India. Information on EA, caesarean sections, conversion of EA, failure of regional anaesthesia, use of general anaesthesia, alternate techniques and supplemental medications were retrieved from electronic medical records.

Results:
Emergency cesarean section (CS) was performed for 4,259 (26.93%, 95% CI: 26.25, 27.63) of 15, 812 parturients that had EA at the study institute between Jan 2012 and December 2016. The EA was successful in 4,078 (95.75%, 95% CI: 95.11, 96.32) of these 4,259 women. Seventy three (1.71%, 95% CI: 1.37, 2.15) of the 4,259 women reported mild discomfort on the VAS for pain and required supplemental sedation for the emergency CS and 108 (2.53%, 95% CI: 2.11, 3.05) of the 4,259 women needed alternate techniques. The failure rate of EA was thus 4.25% (95% CI: 3.68, 4.89, n = 181) in this audit.

Conclusions:
The failure rates of EA at the study institute are well within the recommended standards of the RCA (Royal College of Anaesthesiologists – UK). This audit helped us to develop an algorithmic approach to further improve performance based on problems identified during the audit.
Association Between Internal Medicine Residency Applicant Characteristics and Performance on ACGME Milestones During Intern Year
Authors: Golden Blair P. , Henschen Bruce L. , Liss David T. , Kiely Sara L. , Didwania Aashish K. 
Published: April 2021

ABSTRACT

Background
Residency programs apply varying criteria to the resident selection process. However, it is unclear which applicant characteristics reflect preparedness for residency.

Objective
We determined the applicant characteristics associated with first-year performance in internal medicine residency as assessed by performance on Accreditation Council for Graduate Medical Education (ACGME) Milestones.

Methods
We examined the association between applicant characteristics and performance on ACGME Milestones during intern year for individuals entering Northwestern University's internal medicine residency between 2013 and 2018. We used bivariate analysis and a multivariable linear regression model to determine the association between individual factors and Milestone performance.

Results
Of 203 eligible residents, 198 (98%) were included in the final sample. One hundred fourteen residents (58%) were female, and 116 residents (59%) were White. Mean Step 1 and Step 2 CK scores were 245.5 (SD 12.0) and 258 (SD 10.8) respectively. Step 1 scores, Alpha Omega Alpha membership, medicine clerkship grades, and interview scores were not associated with Milestone performance in the bivariate analysis and were not included in the multivariable model. In the multivariable model, overall clerkship grades, ranking of the medical school, and year entering residency were significantly associated with Milestone performance (P ≤ .04).

Conclusions
Most traditional metrics used in residency selection were not associated with early performance on ACGME Milestones during internal medicine residency.
Focusing on Diversity: A Regional Internal Medicine Residency Viewpoint on Underrepresented Minority Support, Retention, and Mentoring
Authors: Harris Rachel , Covington Kyle , Colford Cristin , Denizard-Thompson Nancy , Contarino Michael , Evans Kimberley , Zaas Aimee , Kraemer M. Suzanne , McNeill Diana 
Published: April 2021

ABSTRACT

Background
While the overall percentage of residents who withdraw (2.7%) or take extended leave (1.0%) are low, subgroup analysis has found that minority physicians are approximately 30% more likely to withdraw from residency than their white counterparts and 8 times more likely to take extended leave of absence. With ongoing national efforts to support diversity in medical education through increased recruitment of underrepresented in medicine (UiM) students to residency programs, there is paucity of data identifying specific experiences challenging or contributing to their overall resiliency. Better understanding of the lived experience of UiM residents will allow residency programs to create successful curricular programing and support structures for residents to thrive.

Objective
We sought to understand UiM internal medicine residents' experiences during residency training.

Methods
We used a retrospective review of focus group transcripts of UiM internal medicine residents from 5 academic institutions in 2017 (4 in North Carolina and 1 in Georgia).

Results
Of 100 self-identified UiM residents from 5 institutions, 59 participated in the focus groups. Using a consensus-based review of transcripts, 25 distinct codes in 8 parent code categories were determined. Two primary themes emerged: resilience and isolation. Three secondary themes—social support, mentorship, and external expectations and/or biases—served as mediators for the primary themes.

Conclusions
UiM residents who became or were already resilient commonly experienced isolation at some time in their medical career, specifically during residency. Moreover, they could be influenced and positively or negatively affected by social support, mentorship, and external expectations and biases.
The Microrna 29 family and its regulation
Authors: Linh Le Thi Truc 
Published: April 2021

Since miRNAs have broad effects on tissue homeostasis, and disease development, it is particularly interesting to work out how miRNAs themselves are being regulated. Such data could provide crucial information for further understanding the mechanism underlying disease development and for being able to manipulate these miRNAs therapeutically. Generally, the expression of miRNAs can be regulated transcriptionally, epigenetically, or
controlled by different stimuli e.g. cytokines and growth factors. In review, just transcription factors, cytokines, and growth factors controlling the miR-29 family expression in human diseases were for the first time investigated.
Propagating arbuscular mycorrhizal fungi associated with coffee plant by using the herbaceous host
Authors: Quyen Dang Hoang , Duong Vu Thuy , Hoang Pham Nguyen Duc 
Published: April 2021

Coffee (Coffea spp.) is one of important industrial crops. Additionally, arbuscular mycorrhizal fungi (AMF) provide many benefits for plants such as increasing nutrient uptake, enhancing tolerance in drought and stress
condition, etc. Therefore, preservation and propagation of AMF spores collected from coffee’s rhizosphere are necessary for coffee cultivation. The AMF preservation on coffee plant is not feasible because coffee is a long-term plants, which led to study on symbiotic ability of AMF on several short-term host plants (maize (Zea mays), plantain (Plantago spp.), rice (Oryza sativa), beggarticks (Bidens pilosa), and bahia grass (Pensacola bahia)) to maintain AM association. Investigation of symbiosis ability with four types of AMF spores showed that maize had the highest rate of fungal infection. The total number of AMF spore per 50g soil after 3 months of inoculation on maize reached 352 spores, which was 4.1 times higher than that of the origin while the lowest figure recorded in bahia grass is with only 2.3 times.
Các marker phân tử ứng dụng trong nhận diện dòng ớt cay bất dục đực bào chất (Cytoplasmic Male Sterility - CMS)
Authors: Linh Lê Thị Trúc , Phượng Hồ Thị Bích , Kính Lê Thị 
Published: April 2021

Bất dục đực bào chất (cytoplasmic male sterility, CMS) là một tính trạng di truyền làm mất chức năng của hạt phấn. Đây là một trong những tính trạng quan trọng trong sản xuất hạt giống lai. Đối với giống lai ớt cay thương
mại, thời gian nhận diện các dòng ớt bất dục đực bào chất bằng phương pháp truyền thống mất nhiều thời gian. Do đó, các marker phân tử đang được phát triển để khắc phục khó khăn này. Với mục đích phát hiện các dòng ớt bất dục đực tại Việt Nam bằng marker phân tử, chúng tôi tiến hành phân tích dữ liệu từ các công trình nghiên cứu trong và ngoài nước. Kết quả phân tích cho thấy, để có thể nhận diện chính xác dòng ớt CMS cần sử dụng kết hợp hai yếu tố: (1) yếu tố nhận diện bào chất S và bào chất N, và (2) yếu tố nhận diện gene Rf và fr. Mỗi yếu tố có nhiều loại marker khác nhau được phát hiện. Bài báo này sẽ giúp cung cấp cơ sở khoa học để chọn lựa các marker tiềm năng và phù hợp với điều kiện hiện tại ở Việt Nam trong phát hiện dòng ớt CMS. Ngoài ra, mồi cần thiết cho phản ứng PCR để nhận diện dòng ớt CMS đã được xác định để làm cơ sở cho các nghiên cứu thực nghiệm sau này
Nghiên cứu quy trình chiết xuất và tinh chế Rotudin từ củ bình vôi (Stephania rotunda lour.) trồng tại tỉnh Hòa Bình
Authors: Hoàng Nguyễn Minh , Quỳnh Tôn Nữ Yên 
Published: April 2021

Củ bình vôi (Stephania rotunda Lour.) trồng tại tỉnh Hòa Bình được sử dụng làm nguyên liệu để chiết xuất l-tetrahydropalmatine (tên hoạt chất thuốc là Rotundin) C21H25NO4 - một alkaloid có tác dụng an thần, gây ngủ, giảm mất trí nhớ. Mục đích của nghiên cứu là tìm ra một quy trình chiết xuất rotudin đơn giản, rẻ tiền, hiệu quả để có thể ứng dụng. Kết quả thu được cho thấy:
- Phương pháp ngâm chiết với tỉ lệ 1/6 giữa bột khô củ bình vôi và thể tích dung dịch H2SO4 1% cho hiệu suất trích ly cao nhất 0,35%. Hợp chất thu được đạt độ tinh khiết 98% (trên HPLC).
- Cấu trúc hóa học được xác nhận trên phổ NMR.