bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer perceptions and behaviour towards branded commodities
Authors: Singh Jaywant , Dall'Olmo Riley Francesca 
Published: August 2021

AbstractThis study investigates consumers' perceived differentiation of branded commodities. Using data from three countries, across four commodity categories, the study examines consumers' brand/attribute associations, brand commitment, and loyalty‐related brand performance measures that are benchmarked against the output from the well‐established NBD‐Dirichlet model. The brand perceptions and brand performance data provide convergent evidence of systematic variations with market share (or brand penetration), rather than idiosyncratic brand differentiation related to the characteristics or equity of individual commodity brands. Overall, the results show that even commodity brands follow the well‐established Dirichlet‐type empirical patterns. The implication is that communication and other marketing‐mix activities should aim to constantly remind consumers of the brand, maintaining the market shares, rather than setting unrealistic targets for increasing loyalty or accentuating brand differentiation.
New Evidence for the Key Role of Hydrogen Bonding BetweenN‐Hydroxyphthalimide and Halide Ionic Liquids in Hydrocarbons Oxidation
Authors: Talik Gabriela , Orlińska Beata 
Published: August 2021

AbstractThis paper demonstrates the catalytic activity of ionic liquids with an 1‐alkyl‐3‐methylimidazolium cation ([Rmim][X]) in the oxidation of ethylbenzene as a model hydrocarbon. The interaction between ionic liquids andN‐hydroxyphthalimide (NHPI) were examinated with or without Co(II). The activity of the studied ionic liquids and selected tetraalkylammonium salts ([R4N][X]) is compared. The influence of the structure of the alkyl substituents [R] and anions (in which [X]=[Cl], [Br], or [I]) on the reaction course was determined. The interaction between NHPI and the selected ionic liquids was proven using1H NMR. It was shown that the formation of hydrogen bonds between the hydrogen atom in the −NOH group in NHPI and the anion [X] in [Rmim][X] influenced the rate of the oxidation reaction by accelerating the formation of theN‐oxyl radical responsible for the NHPI activity.
Ultra‐Sensitive and Ultra‐Stretchable Strain Sensors Based on Emulsion Gels with Broad Operating Temperature
Authors: Chai Chunxiao , Yi Mengjiao , Zhang Zhuo , Huang Zhaohui , Fan Qi , Hao Jingcheng 
Published: August 2021

AbstractHydrogels with mechanical elasticity and conductivity are ideal materials in wearable devices. However, traditional hydrogels are fragile upon mechanical loading and lose functions in climate change because the internal water undergoes freeze and dehydration. Herein, we synthesize stable emulsions at high and low temperatures by introducing glycerol into the W/W emulsions. Then the high‐stable emulsions are used as templates to produce the freestanding emulsion gels with enhanced mechanical strength and conductivity. The introduction of glycerol endows emulsions and emulsion gels with high and low temperature resistance (−20 to 90 °C). The fabricated strain sensors based on emulsion gels show high sensitivity (gauge factor=6.240), high stretchability (1081 %), fatigue resistance, self‐healing and adhesion properties, realizing the repeatable and accurate detection of various human motions. These high‐performance and eco‐friendly emulsion gels can be promising candidates for next‐generation artificial skin and human‐machine interface.
Simultaneous Tuning Band Gaps of Cu2O and TiO2 to Form S‐Scheme Hetero‐Photocatalyst
Authors: Qi Lei , Wang Mei , Xue Jianbin , Zhang Qiyuan , Chen Feng , Liu Qianqian , Li Wanfei , Li Xinheng 
Published: August 2021

AbstractPhotocatalytic Z or S scheme merits higher redox potentials and faster charge separation. However, heterostructure photocatalysts with band gaps of bulk materials often have a type I band structure leading to poor photocatalytic activity. In view of this, we report simultaneous tuning of band gaps of Cu2O and TiO2, where quantum dot Cu2O nanoparticles were formed on doped TiO2 with Ti3+. The reduced size of Cu2O made its conduction band more negative, whereas the introduction of Ti3+ made the absorption edge red shift to the visible light region. The as‐formed heterostructure enabled an S‐Scheme mechanism with remarkable activity and stability for visible light photodegradation of 4‐chlorophenol (4‐CP). The as‐obtained photocatalysts’ activity demonstrated ca. 510‐fold increase as compared to individual ones and a mechanical blend. The as‐obtained photocatalysts maintained over 80 % for 5 cycles and 2 months exposure to O2 did not decrease the degradation rate. ESR characterization and scavenger experiments proved the S‐Scheme mechanism.
A Porphyrin‐Based Covalent Organic Framework for Metal‐Free Photocatalytic Aerobic Oxidative Coupling of Amines
Authors: He Huijie , Fang Xu , Zhai Dong , Zhou Wei , Li Yimeng , Zhao Wenling , Liu Chengcheng , Li Zhen , Deng Weiqiao 
Published: August 2021

AbstractImines are important intermediates in drug synthesis. Photocatalytic aerobic oxidative coupling of amines has been considered as a clean and promising way to produce imines and has attracted great attention. Herein, we designed and synthesized a novel two‐dimensional porphyrin‐based covalent organic framework (Por‐BC‐COF) which adopts an AA stacking mode with excellent crystallinity, high Brunauer–Emmett–Teller surface areas (1200 m2 g−1), wide light absorption range (200–1300 nm) and good stability in a variety of organic solvents. Por‐BC‐COF can be used as a metal‐free heterogeneous photocatalyst for the photocatalytic oxidation of amines to imines under visible light and red light with a high yield (97 %). This work presents a novel and efficient COF photocatalyst in the application of light‐driven organic synthesis.
Trait mindfulness and cross‐cultural sales performance: The role of perceived cultural distance
Authors: Charoensukmongkol Peerayuth , Pandey Arti 
Published: August 2021

AbstractThis research examines the effect of trait mindfulness on cross‐cultural sales performance through the mediating effect of sales planning. Moreover, this research examines whether the direct effect of trait mindfulness on sales planning can be moderated by perceived cultural distance between foreign customers and the salespeople. The hypotheses were developed based on cognitive resource theory. This research collected survey data from 282 Thai salespeople at trade shows in Vietnam, India, and Japan and analyzed them using Partial Least Squares Structural Equation Modeling. The results indicate that sales planning fully mediated the direct association between trait mindfulness and cross‐cultural selling performance, while perceived cultural distance also positively moderated the effect of trait mindfulness on sales planning.
High‐Throughput Screening Identifies Ascorbyl Palmitate as a SIRT2 Deacetylase and Defatty‐Acylase Inhibitor
Authors: Hong Jun Young , Cassel Joel , Yang Jie , Lin Hening , Weiser Brian P. 
Published: August 2021

AbstractSmall‐molecule inhibitors of the human sirtuin SIRT2 are being developed because of their therapeutic potential in a variety of diseases. Here, we developed a high‐throughput screen to identify novel SIRT2 inhibitors using a fluorescent SIRT2 probe, 1‐aminoanthracene (AMA). AMA has high fluorescence when bound to SIRT2, and its fluorescence reduces >10‐fold when it is displaced from SIRT2 by other ligands. We used this property of AMA to screen a library of known bioactive compounds for SIRT2 binding and discovered two known pharmaceutical compounds that bind SIRT2 with Kd values in the low μM range, ascorbyl palmitate and pictilisib. Both compounds inhibit the deacetylase and defatty‐acylase activities of SIRT2. While pictilisib has selectivity for SIRT2, ascorbyl palmitate also inhibits the enzymatic activities of SIRT1 and SIRT6. Finally, we show that ascorbyl palmitate inhibits SIRT2 deacetylase and defatty‐acylase activities in cells, and SIRT2 inhibition by ascorbyl palmitate contributes to the cytotoxicity of the compound. Our work discovered novel SIRT2 deacylase inhibitors and presents a screening approach that can be applied on a larger scale.
A risk‐based framework for assessing real‐time lung cancer screening eligibility that incorporates life expectancy and past screening findings
Authors: Toumazis Iakovos , Alagoz Oguzhan , Leung Ann , Plevritis Sylvia K. 
Published: August 2021

BackgroundCurrent lung cancer risk‐based screening approaches use a single risk‐threshold, disregard life‐expectancy, and ignore past screening findings. We address these limitations with a comprehensive analytical framework, the individualized lung cancer screening decision (ENGAGE) tool that aims to optimize lung cancer screening for US ever‐smokers under dynamic risk assessment by incorporating life expectancy and past screening findings over time.MethodsENGAGE employs a partially observable Markov decision process framework that integrates published risk prediction and disease progression models, to dynamically assess the trade‐off between the expected health benefits and harms associated with screening. ENGAGE evaluates lung cancer risk annually and provides real‐time screening eligibility that maximizes the expected quality‐adjusted life‐years (QALYs) of ever‐smokers. We compare ENGAGE against the 2013 U.S. Preventive Services Task Force (USPSTF) lung cancer screening guideline and single‐threshold risk‐based screening paradigms.ResultsCompared with the 2013 USPSTF guidelines, ENGAGE expands screening coverage among ever‐smokers (ENGAGE: 78%, USPSTF: 61%), while reducing the number of screening examinations per person (ENGAGE:10.43, USPSTF:12.07, P < .001), yields higher effectiveness in terms of increased lung cancer‐specific mortality reduction (ENGAGE: 19%, USPSTF: 15%, P < .001) and improves screening efficiency (ENGAGE: 696, USPSTF: 819 screens per death avoided, P < .001). When compared against a single‐threshold risk‐based screening strategy, ENGAGE increases QALY requiring 30% fewer screens per death avoided (ENGAGE: 696, single‐threshold: 889, P < .001), and reduces false positives by 40%.ConclusionsENGAGE provides a comprehensive framework for dynamic risk‐based assessment of lung cancer screening eligibility by incorporating life expectancy and past screening findings that can serve to guide future policies on the effectiveness and efficiency of screening.Lay Summary

A novel decision‐analytical screening framework was developed for lung cancer, the individualized lung cancer screening decision (ENGAGE) tool to provide personalized screening schedules for ever‐smokers.

ENGAGE captures the dynamic nature of lung cancer risk and incorporates life expectancy into the screening decision‐making process.

ENGAGE integrates past screening findings and changes in smoking behavior of individuals and provides informed screening decisions that outperform existing screening guidelines and single‐threshold risk‐based screening approaches.

A personalized lung cancer screening program facilitated by a tool such as ENGAGE could enhance the efficiency of lung cancer screening.
Setting international standards for patient and parent involvement and engagement in childhood, adolescent and young adult cancer research: A report from a European Collaborative Workshop
Authors: Polanco Angela , Al‐Saadi Reem , Tugnait Suzanne , Scobie Nicole , Pritchard‐Jones Kathy 
Published: August 2021

AbstractBackgroundPatient and Public Involvement and Engagement (PPIE) in research, advocates for research conducted ‘with’ not ‘for’ the affected population. In paediatric oncology research, the parents of children, adolescents and young adults affected by cancer are represented by the term ‘public’ in the acronym PPIE. Patients (those with cancer and cancer survivors) are also passionate advocates who drive forward the research priorities of children, adolescents and young adults throughout the entire research process.AimsA workshop was held at an international professional meeting in 2019 with the aim to define Patient and Parent Involvement and Engagement (PPIE); capture PPIE activities on a European level; and to explore the role of PPIE in non‐interventional research. A proposed framework for a European PPIE strategy for childhood, adolescent and young adult cancers was also discussed.MethodsThe 60‐minute workshop was attended by health care professionals, researchers, scientists, parents, survivors and charity/support organisations. A presentation to define PPIE, including the difference in terminology for PPIE in the context of childhood, adolescent, and young adult cancers was discussed. Best practice examples from the United Kingdom (UK) helped to demonstrate the positive impact of PPIE in paediatric oncology research. Three breakout groups then explored themes relating to PPIE, namely PPIE priorities, PPIE mapping for Europe, and PPIE in non‐interventional research and data‐linkage.ResultsDisparity in PPIE activities across Europe was evident, with ambiguity surrounding terminology and expected roles for PPIE representatives in paediatric oncology research. A lack of PPIE activity in Eastern Europe correlated with a lack of availability for clinical trials and poorer survival rates for paediatric oncology patients. There was unanimous support for PPIE embedded research in all areas, including in non‐interventional studies.ConclusionA European‐level definition of PPIE for paediatric oncology research is needed. Further exploration into the role and responsibilities of patients, parents, and professionals when undertaking PPIE related activities is also recommended. Best practice examples from the UK, France, Germany, The Netherlands and Belgium demonstrated a preliminary evidence base from which a European PPIE strategy framework can be designed, inclusive of the patient and parent voice.
Lanthanide‐Based Complexes Containing a Chiral trans‐1,2‐Diaminocyclohexane (DACH) Backbone: Spectroscopic Properties and Potential Applications
Authors: Piccinelli Fabio , Nardon Chiara , Bettinelli Marco , Melchior Andrea , Tolazzi Marilena , Zinna Francesco , Di Bari Lorenzo 
Published: August 2021

AbstractIn this minireview, we give an overview on the use of the chiral molecule trans‐1,2‐diaminocyclohexane (DACH) in several fields of application. This chiral backbone is present in a variety of metal complexes which are employed in (enantioselective) catalysis, chiral discrimination, molecular recognition and supramolecular chemistry. Metal extraction and biochemical and pharmaceutical applications also use the DACH molecule. This contribution is particularly focused on the interesting chemical‐physical properties discussed so far in the literature concerning lanthanide‐based complexes containing chiral ligands characterized by the presence of DACH in the structure. In particular, the interconnection between luminescence (total and circularly polarized), structure and thermodynamics of Eu(III), Tb(III) and Sm(III) complexes will be discussed also in light of their use as optical or chiroptical probes for the sensing of important analytes dissolved in aprotic and protic polar solvents. Several complexes show potential interest in the solid state as phosphors for light emitting devices or for the detection of volatile organic compounds.
The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study
Authors: Xhakollari Liana , Grubb Anders , Jujic Amra , Bachus Erasmus , Nilsson Peter M. , Leosdottir Margret , Christensson Anders , Magnusson Martin 
Published: August 2021

AbstractAimsThis study aimed to investigate the association between the ‘Shrunken pore syndrome’ (SPS) and risk of death, 30 day rehospitalization, and health‐related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C/eGFRcreatinine ratio.Methods and resultsA total of 373 patients hospitalized for HF [mean age 74.8 (±12.1) years; 118 (31.6%) women] were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST‐Malmö). Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) formulas were used for estimation of glomerular filtration rate (eGFR). Presence of SPS was defined as eGFRcystatin C ≤ 60% of eGFRcreatinine. In Cox regression multivariate models, associations between SPS, risk of death (median follow‐up time 1.8 years), and risk of 30 day rehospitalization were studied. Associations between SPS and impaired QoL were studied using multivariate logistic regressions. In multivariate models, SPS was associated with all‐cause mortality [124 events; hazard ratio (HR) 1.99; 95% confidence interval (95% CI) 1.23–3.21; P = 0.005] and with 30 day rehospitalization (70 events; HR 1.82; CI 95% 1.04–3.18; P = 0.036). Analyses of QoL, based on a Kansas City Cardiomyopathy Questionnaire overall score < 50, revealed that SPS was associated with higher risk of low health‐related QoL (odds ratios 2.15; CI 95% 1.03–4.49; P = 0.042).ConclusionsThe results of this observational study show for the first time an association between SPS and poor prognosis in HF. Further studies are needed to confirm the results in HF cohorts and experimental settings to identify pathophysiological mechanisms.
Neutrophils pro‐inflammatory and anti‐inflammatory cytokine release in patients with heart failure and reduced ejection fraction
Authors: Chaar Diana , Dumont Benjamin , Vulesevic Branka , Neagoe Paul‐Eduard , Rakel Agnes , Sirois Martin G. , White Michel 
Published: August 2021

AbstractAimsHeart failure with reduced ejection fraction (HFrEF) is characterized by sub‐clinical inflammation. Changes in selected biomarkers of inflammation concomitant with the release of pro‐inflammatory and anti‐inflammatory cytokines by neutrophils have not been investigated in patients with HFrEF.Methods and resultsFifty‐two patients, aged 68.8 ± 1.7 years, with HFrEF and left ventricular ejection fraction 28.7 ± 1.0%, and 21 healthy controls (CTL) were recruited. Twenty‐five HF patients had type 2 diabetes. Venous blood samples from HF and CTL were collected once. Neutrophil‐derived pro‐inflammatory and anti‐inflammatory cytokine levels were assessed in plasma by ELISA. Plasma biomarkers assessed included: C‐reactive protein (CRP), vascular endothelial growth factor (VEGF), interleukins (IL)‐6, ‐8, ‐1 receptor antagonist (‐1RA), nitric oxide (NO), soluble intercellular adhesion molecule‐1 (sICAM‐1), vascular cell adhesion molecule 1 (sVCAM‐1) and E‐Selectin (sE‐Sel). Neutrophils were isolated and stimulated with various agonists to promote VEGF, IL‐6, IL‐8, and IL‐1RA release. Compared with CTL, HFrEF patients showed a marked decrease in circulating VEGF [178.0 (interquartile range; IQR 99.6; 239.2) vs. 16.2 (IQR 9.3; 20.2) pg/mL, P ≤ 0.001] and NO [45.2 (IQR 42.1; 57.6) vs. 40.6 (IQR 30.4; 47.1) pg/mL, P = 0.0234]. All other circulating biomarkers were significantly elevated. Neutrophils isolated from patients with HFrEF exhibited a greater IL‐8 release in response to LPS [1.2 ± 0.1 (CTL); 10.4 ± 1.6 ng/mL (HFrEF) and 12.4 ± 1.6 ng/mL (HFrEF and DM), P ≤ 0.001]. IL‐6 release in response to LPS was not changed in HFrEF patients without diabetes, whereas it was significantly increased in patients with HFrEF and diabetes [46.7 ± 3.9 (CTL) vs. 165.8 ± 48.0 pg/mL (HFrEF), P = 0.1713 and vs. 397.7 ± 67.4 pg/mL (HFrEF and DM), P ≤ 0.001]. In contrast, the release of VEGF and IL‐1RA was significantly reduced in HFrEF (VEGF; TNF‐α: 38.6 ± 3.1 and LPS: 25.3 ± 2.6 pg/mL; IL1RA; TNF‐α: 0.6 ± 0.04 and LPS: 0.3 ± 0.02 ng/mL) compared with CTL (VEGF; TNF‐α: 60.0 ± 9.4 and LPS: 41.2 ± 5.9 pg/mL; IL1RA; TNF‐α: 3.3 ± 0.2 and LPS: 2.3 ± 0.1 ng/mL).ConclusionsPatients with HFrEF exhibit a significant decrease in circulating VEGF. The release of VEGF and both pro‐inflammatory and anti‐inflammatory cytokines from the stimulated neutrophils is markedly altered in these patients. The clinical significance of these findings deserves further investigation.
Acute pleiotropic effects of dapagliflozin in type 2 diabetic patients with heart failure with reduced ejection fraction: a crossover trial
Authors: Ilyas Fahmida , Jones Lynette , Tee Su Ling , Horsfall Matthew , Swan Amy , Wollaston Fiona , Hecker Tracy , De Pasquale Carla , Thomas Simeoni , Chong William , Stranks Steve , Mangoni Arduino A. , Selvanayagam Joseph B. , Chew Derek P. , De Pasquale Carmine G. 
Published: August 2021

AbstractAimsThis study aimed to explore the rapid effects of dapagliflozin in heart failure with reduced ejection fraction (HFrEF).Methods and resultsWe studied the functional, echocardiographic, electrophysiological, lung ultrasound, ambulatory blood pressure (BP), microvascular and macrovascular function, and biochemical effects of 2 week treatment with dapagliflozin in 19 type 2 diabetic HFrEF patients in a double‐blind, crossover, placebo‐controlled trial. Dapagliflozin had no significant effect on clinical, functional, or quality of life parameters. Dapagliflozin reduced systolic BP [114 (105, 131) vs. 106 (98, 113) mmHg, P < 0.01] and diastolic BP [71 (61, 78) vs. 62 (55, 70) mmHg, P < 0.01]. There was no effect on cardiac chamber size, ventricular systolic function, lung ultrasound, or arterial wave reflection. Dapagliflozin increased creatinine [117 (92, 129) vs. 122 (107, 135) μmol/L, P < 0.05] and haemoglobin [135 (118, 138) vs. 136 (123, 144) g/L, P < 0.05]. There was a reduction in ventricular ectopy [1.4 (0.1, 2.9) vs. 0.2 (0.1, 1.4) %, P < 0.05] and an increase in standard deviation of normal heart beat intervals [70 (58, 90) vs. 74 (62, 103), P < 0.05]. Unexpectedly, dapagliflozin increased high‐sensitivity troponin T [25 (19, 37) vs. 28 (20, 42) ng/L, P < 0.01] and reduced reactive hyperaemia index [1.29 (1.21, 1.56) vs. 1.40 (1.23, 1.84), P < 0.05].ConclusionsAfter 2 weeks, while multiple parameters supported BP reduction and haemoconcentration with dapagliflozin, reduction in cardiac filling pressure, lung water, and functional improvement was not shown. Reduced ventricular ectopic burden suggests an early antiarrhythmic benefit. The small increase in troponin T and the reduction in the reactive hyperaemia index warrant further mechanistic exploration in this treatment of proven mortality benefit in HFrEF.
Transition‐Metal‐Free Ring‐Opening Reaction of 2‐Halocyclobutanols through Ring Contraction
Authors: Oeser Petr , Edlová Tereza , Čubiňák Marek , Tobrman Tomáš 
Published: August 2021

AbstractThe present work describes the preparation of halohydrins from 2‐halocyclobutanones by means of reactions with Grignard reagents at −78 °C. We discovered that the prepared cyclobutanols underwent a thermal ring‐opening reaction. Depending on the structure of the starting cyclobutanol, different products were formed. More specifically, 1‐substituted 2‐bromocyclobutan‐1‐ol was found to open to γ‐substituted butyrophenones. A novel 1,3‐dihydro‐2H‐inden‐2‐ylidene derivative was obtained for indene‐derived cyclobutanols. Based on the outcomes of the performed experiments, a mechanism for the ring‐opening of cyclobutanols can be proposed.