bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Health Benefits of a Pomegranate Extract, Rich in Phenolic Compounds, in Intestinal Inflammation
Authors: Raffaele Marco , Greish Khaled , Vanella Luca , Carota Giuseppe , Bahman Fatemah , Bindayna Khalid M. , Ezzat Hicham , Salerno Loredana , Pittalà Valeria , Ballistreri Gabriele , Amenta Margherita , Sorrenti Valeria 
Published: February 2021

Background:
Pomegranate is a fruit rich in bioactive compounds such as punicalagins,
gallic acid, and ellagic acid derivatives. It has been widely used since ancient times in traditional
medicine for a wide variety of diseases. It has been reported that bioactive compounds, such as polyphenols,
are able to induce the expression of cytoprotective enzymes, including HO-1. The contribution
of HO-1 activity to the prevention of intestinal inflammation has been shown in different
models of Inflammatory bowel diseases (IBD).

Objective:
Aim of the present research was to investigate the molecular mechanisms involved in
the beneficial effects of a pomegranate extract (PE), rich in bioactive compounds in intestinal inflammation.

Methods:
Caco-2 cells exposed to LPS and DSS induced colitis were chosen as convenient experimental
models of intestinal inflammation.

Results:
Results obtained in our experimental conditions showed that PE in vitro was able to induce
HO-1 and to reduce cellular damage and oxidative stress through an increase of GSH levels.
Moreover, PE was able to decrease the pro-inflammatory marker IL-8 levels and activate TIGAR
pathway. The results obtained in vivo, in agreement with the data obtained in vitro, highlighted the
ability of PE to reduce intestinal inflammation, preserve the colon length and histological features
and reduce IL-6 levels compared to the DSS treated group.

Conclusion:
PE, rich in bioactive compounds, could contribute, as a supportive therapy, to enhance
the effects of the conventional therapeutic strategies on the management of IBD.
Asafoetida, Natural Medicine for Future
Authors: Shahrajabian Mohamad Hesam , Sun Wenli , Cheng Qi 
Published: February 2021

Background:
Asafoetida is dried latex that is extracted from the taproot of many species
of Ferula, a perennial herb native to the East Mediterranean and Central Asian regions. It is also a
common ingredient in some cuisines.

Objective:
The goal of this manuscript is to survey on medicinal values and natural benefits of Asafoetida.

Methods:
A literature search was conducted in Science Direct, Google, Google Scholar, PubMed,
Wiley Online Library, Springer, and Medline.

Results:
The most important health benefits consist of reducing bloating, helping to relieve asthma,
lower blood pressure and menstrual pain, as well as treating headaches, insect bites, indigestion,
and as a laxative. It is good for diabetic people, treats nerve disorders, helps fight free radicals, aids
in reducing acne, treats corns and calluses, and reduces hair loss.

Conclusion:
This review article allowed verifying Asafoetida as sources of compounds with valuable
nutritional and bioactive properties with great incorporation into foods with functional properties.
Serum Vitamin D Levels at Different Stages of Acne Vulgaris Patients Treated with Isotretinoin: A Prospective Study
Authors: Al-Dhubaibi Mohammed , Alhetheli Ghadah , Alsenaid Adel , Elneam Ahmed Abd 
Published: February 2021

Background: Acne vulgaris is a common chronic inflammatory skin disorder of pilosebaceous units. Isotretinoin (13-cis retinoic acid) is the most effective multifunctional treatment for moderate-to-severe and nodulocystic acne. Vitamin D plays a role in the immune system, and its deficiency might contribute to the pathogenesis of acne.

Objective: To investigate whether isotretinoin improves serum 25-hydroxyvitamin D levels in acne vulgaris patients.

Methods: This prospective cohort study included 68 patients with acne vulgaris. Lipid profiles, liver function tests, and serum 25-hydroxyvitamin D [25 (OH) D] levels were measured at baseline and three months after starting isotretinoin treatment.

Results: There was a significant increase in serum vitamin D levels three months after starting isotretinoin treatment in mild acne patients (P=0.0003).

Conclusion: Vitamin D levels are altered in acne vulgaris. Isotretinoin therapy is associated with an increase in vitamin D levels, which was statistically significant in mild acne patients. Considering the role of vitamin D in acne, effective treatment with isotretinoin might highlight vitamin D as a possible target for acne therapy or as a biomarker for disease activity and remission.
Effect of the Surfactant and Liquid Lipid Type in the Physico-chemical Characteristics of Beeswax-based Nanostructured Lipid Carrier (NLC) of Metformin
Authors: Qushawy Mona 
Published: February 2021

Background:
Metformin (MF) is an antidiabetic drug that belongs to class III of the biopharmaceutical
classification system (BCS) characterized by high solubility and low permeability.

Objective:
The study aimed to prepare metformin as nanostructured lipid carriers (MF-NLCs) to
control the drug release and enhance its permeability through the biological membrane.

Methods:
22 full factorial design was used to make the design of MF-NLCs formulations. MFNLCs
were prepared by hot-melt homogenization-ultra sonication technique using beeswax as
solid lipid in the presence of liquid lipid (either capryol 90 or oleic acid) and surfactant (either
poloxamer 188 or tween 80).

Results:
The entrapment efficiency (EE%) of MF-NLCs was ranged from 85.2±2.5 to 96.5±1.8%.
The particle size was in the nanoscale (134.6±4.1 to 264.1±4.6 nm). The value of zeta potential has
a negative value ranged from -25.6±1.1 to -39.4±0.9 mV. The PDI value was in the range of
0.253±0.01 to 0.496±0.02. The cumulative drug release was calculated for MF-NLCs and it was
found that Q12h ranged from 90.5±1.7% for MF-NLC1 to 99.3±2.8 for MF-NLC4. Infra-red (IR)
spectroscopy and differential scanning calorimetry (DSC) studies revealed the compatibility of the
drug with other ingredients. MF-NLC4 was found to be the optimized formulation with the best responses.

Conclusion:
22 full factorial design succeed to obtain an optimized formulation which controls the
drug release and increases the drug penetration.
Extractos vegetales: una alternativa para el control de enfermedades en el cultivo de cacao (Theobroma cacao)
Authors: Guerrero Raquel , Risco Gabriela , Cevallos Orly , Villamar Ronald , Peñaherrera Sofía 
Published: February 2021

El cacao (Theobroma cacao) enfrenta durante cada uno de sus ciclos productivos patógenos que disminuyen considerablemente a su producción. Cada año fitopatógenos como Moniliophthora roreri y Phytophthora palmivora afectan directamente a las mazorcas y pueden llegar a generar graves pérdidas. Esta investigación se desarrolló con la finalidad de identificar especies vegetales locales cuyos extractos contengan compuestos que tienen la capacidad de reducir la germinación de las esporas de los patógenos, así como también el desarrollo de micelio de los mismos. Extractos de las especies Bledo (Amaranthus bledo), Coquito (Cyperus odoratus), Lechosa (Euphorbia hirta), Rosa de muerto (Tagetes minuta), Teatina (Scoparia dulcis) y Verdolaga (Portulaca oleracea) se utilizaron para enmendar medios de cultivos en concentraciones de 10, 20 y 30%, sobre los cuales se inocularon suspensiones de esporas y discos de micelio de los patógenos. Transcurridos los periodos de incubación se evaluaron los porcentajes de germinación, porcentaje de inhibición de desarrollo del micelio, actividad fungicida de los extractos y su efecto sobre las estructuras de las hifas de los patógenos. Los resultados mostraron que todos los extractos en alguna medida influyeron en alguna medida en el desarrollo de los patógenos en todas las variables estudiadas, sin embargo, Amaranthus bledo y Euphorbia hirta fueron aquellas especies cuyo efecto fue notablemente superior a las otras especies en estudio, lo que indicaría que son especies con potencial para controlar los patógenos a nivel de campo.
Characteristics and Outcomes of Physician-to-Physician Telephone Consultation Programs: Environmental Scan
Authors: Tian Peter George Jaminal , Harris Jeffrey Richard , Seikaly Hadi , Chambers Thane , Alvarado Sara , Eurich Dean 
Published: February 2021

Background
Telephone consultations between physicians provide quick access to medical advice, allowing patients to be cared for by calling physicians in their local settings.

Objective
As part of a quality assurance study of a physician-to-physician consultation program in Alberta, Canada, this environmental scan aims to identify the characteristics and outcomes of physician-to-physician telephone consultation programs across several countries.

Methods
We searched 7 databases to identify English publications in 2007-2017 describing physician-to-physician consultations using telephones as the main technology. To identify Canadian programs, the literature search was supplemented with an additional internet search.

Results
The literature search yielded 2336 citations, of which 17 publications were included. Across 7 countries, 14 telephone consultation programs provided primary care providers with access to various specialists through hotlines, paging systems, or call centers. The programs reported on the avoidance of hospitalizations, emergency department visits and specialty visits, caller satisfaction with the telephone consultation, and cost avoidance.

Conclusions
Telephone consultation programs between health care providers have facilitated access to specialist care and prevented acute care use.
Development of a Breech-Specific Integrated Care Pathway for Pregnant Women: Protocol for a Mixed Methods Study
Authors: Morris Sara , Geraghty Sadie , Sundin Deborah 
Published: February 2021

Background
The development of an integrated care pathway with multidisciplinary input to standardize and streamline care for pregnant women experiencing breech presentation at 36 or more weeks of gestation poses several challenges because of the divisive and contentious nature of the phenomenon. Although many clinicians are interested in obtaining the skills required to safely support women desiring a vaginal breech birth, the primary trend in most health care facilities is to recommend a cesarean section.

Objective
This paper aims to discuss the mixed methods approach used in a doctoral study conducted to generate new knowledge regarding women’s experiences of breech birth in Western Australia and professional recommendations regarding the care of women experiencing breech presentation close to or at term. This study was designed to inform the development of an integrated care pathway for women experiencing a breech presentation. This mixed methods approach situated within the pragmatic paradigm was determined to be the optimal way for incorporating multidisciplinary recommendations with current clinical practice guidelines and consumer feedback.

Methods
A mixed methods study utilizing semistructured interviews, an electronic Delphi (e-Delphi) study, and clinical practice guideline appraisal was conducted to generate new data. The interviews were designed to provide insights and understanding of the experiences of women in Western Australia who are diagnosed with a breech presentation. The e-Delphi study explored childbirth professionals’ knowledge, opinions, and recommendations for the care of women experiencing breech presentation close to or at term. The clinical practice guideline appraisal will examine the current national and professional breech management and care guidelines. This study has the potential to highlight areas in practice that may need improvement and enable clinicians to better support women through what can be a difficult time.

Results
Data collection for this study began in November 2018 and concluded in March 2020. Data analysis is currently taking place, and the results will be disseminated through publication when the analysis is complete.

Conclusions
The results of this study will guide the development of an integrated care pathway for women experiencing a breech presentation close to or at term, with the hope of moving toward standardized breech care for women in Western Australia. This study protocol has the potential to be used as a research framework for future studies of a similar nature.

International Registered Report Identifier (IRRID)
DERR1-10.2196/23514
Faktor - faktor yang mempengaruhi migrasi masuk di Kota Jambi (studi kasus etnis Jawa di Kelurahan Buluran Kenali)
Authors: Anggara Sulung Tino , Junaidi Junaidi , Yulmardi Yulmardi 
Published: February 2021

Research objectives: 1) To determine the characteristics of Javanese ethnic groups in Buluran Kenali Village; 2) To find out and analyze the influence of age, origin, education level and length of stay on the income of Javanese ethnic migrant residents in the Buluran Kenali Village. The data used in this study are primary data obtained from survey results by distributing questionnaires and interviews. The analytical method used in this study is descriptive and quantitative analysis methods, using multiple linear regression analysis. The results of this study indicates that the average age of migrants is 44 years old, married with a total of 2 people, education that has completed an average of 10 years comes directly from Java, with the reason of moving to Jambi City due to family invitation and knowing the City Jambi from family/friends. From the results of multiple linear regression it is known that age, origin, level of education, length of stay have an effect on and significantly affect the income of ethnic Javanese migrants in Jambi City. Partially, age, education and length of stay influence and significantly affect the income of Javanese ethnic migrants in Jambi City, while the origin does not affect and the income of ethnic Javanese migrants in Jambi City.
Keywords: Migration, Income, Age, Origin, Education Level, Length of Stay.
EDUCAÇÃO EM MOVIMENTO: RELATO DE EXPERIÊNCIA DE EXTENSÃO POPULAR
Authors: Brutscher Volmir José , Hérika Costa Praia  , Áurea Galdino de Lima  
Published: February 2021

Este artigo é um relato de experiência vivenciada a partir do evento de extensão Educação em Movimento: Educação do Campo e Movimentos Sociais, realizado em junho de 2019, no Campus Mata Norte da Universidade de Pernambuco (UPE), ligado às disciplinas Educação do Campo e Educação e Movimentos Sociais, do Curso de Pedagogia, e apoiado por um grupo de estudos da área. Foi realizado em parceria com a Gerência Regional de Educação (GRE) da Mata Norte, o Centro Acadêmico do Curso de Pedagogia (CAPed) e o Programa Nacional de Formação de Professores da Educação Básica (PAFOR). Teve por objetivo refletir acerca da temática no contexto da globalização e virtualização, considerando avanços, retrocessos e perspectivas face à conjuntura política atual do país. Contou com a participação de convidados dos movimentos sociais populares de Pernambuco, que desenvolveram uma reflexão organicamente crítica. O evento contribuiu para fortalecer a aproximação da UPE das causas e perspectivas dos movimentos populares e, a partir do encontro direto entre os estudantes e as lideranças populares, colaborou para sensibilizar os discentes para as questões latentes que envolvem os sujeitos do campo, como a promoção da agroecologia, da educação e da cidadania no combate às desigualdades sociais e às injustiças.
Internal Controls and Operational Performance of Nonprofit Organizations
Authors: Berglund Nathan R. , Sterin Mikhail 
Published: February 2021

ABSTRACT
This study examines the impact of auditor-reported internal control deficiencies (ICDs) on operational performance within nonprofit organizations. Contemporary studies in the for-profit environment document evidence that poor internal controls over financial reporting (ICFR) cause suboptimal operational performance. While these analyses are restricted to ICFR, the nonprofit environment allows external stakeholders to observe the effectiveness of both ICFR and internal controls over compliance. We find robust evidence of negative associations between both ICD types and two key measures of nonprofit operational performance: surplus and the charitable expense ratio. Our findings are relevant to multiple nonprofit stakeholders, demonstrating that the control environment has a pervasive impact on a nonprofit's ability to effectively execute its charitable mission.
JEL Classifications: M41; M42.
Perceived pain during rapid maxillary expansion in children with different expanders:
Authors: de Araújo Marília Carolina , Bocato Jessica Rico , Berger Sandrine Bittencourt , Oltramari Paula Vanessa Pedron , de Castro Ferreira Conti Ana Cláudia , de Almeida Marcio Rodrigues , Freire Fernandes Thais Maria 
Published: February 2021

ABSTRACT

Objectives
To evaluate and compare the intensity of pain caused by rapid maxillary expansion (RME) with two expanders: Hyrax and Haas type, in growing patients.

Materials and Methods
Thirty-nine patients (23 girls and 16 boys) with an average age of 9.3 years (SD = 1.39 years) were randomized into two groups and treated with Hyrax- and Haas-type expanders. In both groups, initial activation of the expander screw was one full turn on the first day followed by 2/4 of a turn two times a day (morning and night) for 7 days. Inclusion criteria were patients presenting with a posterior crossbite or maxillary atresia between 7 and 12 years old. To evaluate the intensity of pain during the active phase of the treatment, a combination of the Numerical Rating Scale and Wong-Baker Faces Pain Scale was used. Mann-Whitney test was used to compare the two treatment groups.

Results
There was significant inverse correlation between days following insertion and pain. During the expansion period, 100% of the children reported some pain. Hyrax expander subjects reported greater pain than those treated with the Haas-type expander only on the first day. The level of pain remained greater in girls throughout treatment.

Conclusions
Pain was reported regardless of the type of expander and was higher in the Hyrax group only on the first day of activation.
DIKSI DALAM TEKS DESKRIPSI SISWA KELAS VII SMP NEGERI 11 PADANG
Authors: Tenesia Tevani , Thamsin Andria Catri 
Published: February 2021

ABSTRACT This research is motivated by the problems in writing description texts of seventh grade students at SMPN 11 Padang. This type of research is qualitative research using descriptive methods. The data from this study is the use of diction in the description text of SMPN 11 Padang students. The data sources used in this study are the sentences in the description text written by seventh grade students of SMPN 11 Padang. The researcher only discussed and examined 30 description text writtings written by seventh grade students of SMPN 11 Padang. Based on the results of the study, the following points can be concluded. First, the description text of class VII of SMPN 11 Padang in the use of diction is more dominant having accurary, precision, and harmony in word selection. This can be proven from 30 student description texts consisting of 96 paragraphs, 332 sentences, and 3,567 dictionaries. There are 3.126 accurary in word selection, 3,507 precision in word selection, and 3,494 harmony in word selection. Second, from the student’s description text, it can be seen that there are still students who don’t understand about the use of diction. It can be seen from 3,567 diction used, there are still innaccuracies in the diction as much as 441 words, the accuracy of diction is 60 words, and the incompatibility of diction is 73 words. Third, students still don’t understand the use of spelling in accordance with the Indonesian spelling rules. Kata kunci : Kualitatif, Menulis, Teks Deskripsi, Diksi
KORELASI PENGUASAAN KOSAKATA BIDANG LINGKUNGAN DENGAN KETERAMPILAN MENULIS TEKS EKSPOSISI SISWA KELAS VIII SMP NEGERI 3 PADANG PANJANG
Authors: Nilawati Debby Ayu , Ratna Ellya 
Published: February 2021

ABSTRACT This article was written to describe the relation the mastery of the vocabulary environment to the skill writting the text of the exposition students in class VIII padang Panjang Junior High School 3. This type of research is quantitative with descriptive method and correlational design. The sample in this study amounted to 44 people. The data of this research is score the mastery of the vocabulary environment the exposition text and skill test result writting the text of exposition. The data were gotten through an objective test intended to measure the students the mastery of the vocabulary environment and performance test intended to measure the students skills of writting the text of exposition. Based on data analysis, the following three things are obtained. First, skill of writing the exposition text students in class VIII padang Panjang Junior High School 3 is in good qualification (81,91). Second, the skill the mastery of the vocabulary environment the exposition text of students in class VIII padang Panjang Junior High School 3 is in good qualification (82,05). Third, there was a significant corelation between the students the mastery of the vocabulary environment of exposition text with the skills of writing the exposition text of strudent of class VIII padang Panjang Junior High School 3 in which the significance level 95% with the degrees of freedom n-1 (dk = n-1). Based on this, it was concluded that writing an exposition text requers the mastery of environmental vocabulary. Kata kunci: Korelasi, Kosakata, Menulis, dan Teks Eksposisi
KEEFEKTIFAN KALIMAT DALAM TEKS EKSPLANASI SISWA KELAS VIII SMP PEMBANGUNAN LABORATORIUM UNP
Authors: Syukur Mita , Emidar Emidar 
Published: February 2021

ABSTRACT The purpose of this study is to describe the sentences in the explanatory text of students in terms of four things. First, the effectiveness of sentences in terms of structural clarity, there are 78 (19.60%) errors. The ineffectiveness of the sentence is in the active / passive structure (1 error), the subject is not an explanation (21 errors), the predicate is not lost (28 errors), the description is not in the form of a subject (4 errors), and the subject is not lost (25 errors). Second, the effectiveness of sentences in terms of logical meaning there are 76 (19.09%) errors. The ineffectiveness of the sentence lies in the logical relationship S and P (52 errors) and the logical relationship of details or parallel meaning (23 errors). Third, the effectiveness of sentences in terms of word saving is 142 (35.68%) errors. The ineffectiveness of the sentence is on one subject from the same subject (46 errors), one word from several synonymous words (21 errors), and the required word (115 errors). Fourth, the effectiveness of sentences in terms of word rigidity there are 102 (25.63%) errors. Based on these results it can be concluded that the sentences in the explanatory text of eighth grade students of SMP Pembangunan Laboratorium Laboratory are not effective. This is evidenced from the 221 sentences studied, there were 31 (14.03%) effective sentences and 190 (85.97%) ineffective sentences with 398 errors. Kata kunci: Keefektifan Kalimat, Teks Eksplanasi