bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of walking assistive device for children with cerebral palsy, Vestmiles
Authors: Budiarti Agnes , Yuamita Ferida , Miranda Suci 
Published: April 2021

Celebral Palsy (CP) is a disorder of muscle control which results from some damage to part of the brain. Children with cerebral palsy can have problems such as muscle weakness, awkardness, slowness, shakiness, and difficulty with balance. In severe cerebral palsy, the child may have many difficulties in performing everyday tasks and movements. However, a proper treatment often brings an improvement, though not a cure. In terms of independent mobility particularly walking and standing, this study aims to design a walking assistive device called Vestmiles. The product design includes four parts: a belt, vest, sandals for parents, and sandals for children with the length and height successively: 47.3 cm and a 23 cm; 39.3 cm and 59 cm; 26.9 cm and 9.9 cm (parents’ size of slippers); 23.9 cm and 6 cm (children’s size of slippers). To design the product, it is used the measurement gained from 3 Celebral Palsy children. This work is not only to support physiotherapy program, but also increasing relationship between children and parents. Vestmiles is a user friendly, lightweight, adaptable, efficient and cost effective device.
Scientific-Based Guided Inquiry Learning Model in Learning Chemistry in Class XI IPA Students of SMAN 1 Rote Timur
Authors: Ledoh Cartika Candra , Raharjo Sentot Budi , Saputrome Sulistyo 
Published: April 2021

The purpose of this study is to determine the cognitive and effective learning outcomes of chemistry students using a scientifically based guided inquiry learning model. This study employed a quantitative methodology.. The population in this study consisted of 58 students from class XI at State Senior High School 1 Rote Timur, NTT For the 2019/2020 academic yea. Cluster random sampling was used to select the sample, which included two experimental and control classes. Tests, questionnaires, and observation sheets were used to collect data. The independent test samples t-test was used to analyze student learning outcomes. The finding showed that learning outcomes using the Scientific-Based Guided Inquiry Model and the direct method differs significantly from average high school learning outcomes. The results of the two aspects of learning outcomes, namely aspects of knowledge, and attitudes show a value of p <0.05 so that H0 is rejected and Ha is accepted. Thus, there are differences in student learning outcomes given the learning method using guided inquiry with students using conventional learning. However, from the results of data analysis, it was obtained that the p-value for the knowledge aspect was 0.000, the pvalue for the attitude aspect was 0.038.
A review on Sandhigatavata and its Management Principles
Authors: Gandagi Nagesh , Patil Shubhangi 
Published: April 2021

In the Ayurvedic classics the aetiopathogenesis and symptomatology of Sandhigata vata is described in concise form. Clinically the description of Sandhigata vata explained in the classical texts is similar to the condition osteoarthritis in modern science. Sandhigatavata is described under Vatavyadhi in all the Samhitas and Sangraha Granthas. In Vriddhavastha, all Dhatus undergo Kshaya, Thus leading to Vataprakopa and making individual prone to many diseases. Among them Sandhigatavata standsÂ top in the list. Having the symptoms like pain, swelling, crepitus, and restricted joint movements. Ayurveda highlighted degenerative diseases under the concepts like â€œDhatu saithilyamâ€ and â€œDhatu kshayamâ€. Sandhigata Vata is one of such disease, which needs a specific target of therapeutic intervention to check or slow down the process of â€œDhatu kshayaâ€ and to pacify Vata. Sandhigatavata may be correlated with degenerative joint disease or Osteoarthritis, which in turn cripples the patient to the maximum, extends and reduces the total working capacity of the person. It limits everyday activities such as walking, dressing, bathing etc., thus making individual handicapped
SATB2-AS1 acts as miR-299-3p sponge to facilitate tumorigenesis in human non-small cell lung cancer
Authors: Wu Xiaofeng , Lu Junti , Chen Wen , Liang Meng , Wang Nan , jlin284@163.com Yanhui Zhou 
Published: April 2021

IntroductionNon-small cell lung cancer (NSCLC), the most common pathological type of lung cancer, is partly responsible for an increasing number of tumor-related deaths worldwide. This study aimed to explore the biological role of the anti-sense transcript of special AT-rich sequence binding protein 2 (SATB2-AS1), a novel cancer-related long non-coding RNA (lncRNA), and illustrate the potential molecular mechanisms.Material and methodsThe expression patterns of SATB2-AS1 were determined via qPCR analysis in clinical samples and tumor cell lines. Kaplan-Meier survival analysis was conducted to assess the relationship between SATB2-AS1 expression and survival time of NSCLC patients. NSCLC tumors were transfected with SATB2-AS1 expression vectors or specific short hairpin RNAs (sh-SATB2-AS1). Tumor cell proliferation, cell cycle progression and apoptosis was detected by MTT assays and flow cytometric method, respectively. Nude mouse transplantation models were applied to investigate the effects of SATB2-AS1 on tumor cell growth in vivo. Bio-informatics analysis, luciferase reporter assays and rescue assays were performed to elucidate possible molecular mechanisms.ResultsSATB2-AS1 up-regulation was observed in tumorous tissues and cell lines. Up-regulated SATB2-AS1 expression was associated with shorter overall survival time of patients. SATB2-AS1 over-expression facilitated tumor cell proliferation, cell cycle progression and survival, while its knockdown inhibited tumor cell proliferation, cell cycle progression and survival. SATB2-AS1 depletion suppressed tumor growth in vivo. SATB2-AS1 was revealed to act as a miR-299-3p sponge to exert carcinogenic role.ConclusionsOur data indicate that SATB2-AS1 acts as a miR-299-3p sponge to facilitate NSCLC development, providing a novel candidate therapeutic target for NSCLC.
Effect of genetic variants in FAS and let-7a on radiation-induced intestinal toxicity in the treatment of prostate cancer
Authors: Guo Honglei , Yuan Feng , Zhu Yancui , He Ling 
Published: April 2021

IntroductionThe present study aimed to explore the effects of pri-let-7a-1 rs10739971 and FAS-670 rs1800682 polymorphisms on the pathogenesis of radiation induced intestinal toxicity in prostate cancer (PC) patients.Material and methods380 PC patients with or without signs of intestinal toxicity were enrolled to study the effects of let-7a rs10739971 and FAS-670 rs1800682 polymorphisms on rectal volume and the risk of intestinal toxicity. In addition, real-time PCR, Western-blot analysis, immunohistochemistry, luciferase assays and computational analyses were performed to explore the mechanism underlying the role of let-7a rs10739971 polymorphism in radiation induced intestinal toxicity.ResultsThe let-7a rs10739971 polymorphism but not the FAS-670 rs1800682 polymorphism was closely related to the risk of radiation induced intestinal toxicity featured by a high rectal volume. In addition, there was no obvious association between the rectal volume and the genotype and allele frequencies of FAS -670 rs1800682 and Pri-let-7a-1 rs10739971 polymorphisms. The GG genotype of let-7a rs10739971 polymorphism reduced let-7a expression but enhanced FAS expression. In addition, the intestinal toxicity (-) group showed a much higher level of let-7a and a much lower level of FAS than the intestinal toxicity (+) group. FAS was a virtual target gene of let-7a, which decreased FAS protein expression in a dose-dependent manner.ConclusionsThe GG genotype of pri-let-7a-1 rs10739971 polymorphism could increase the risk of radiation induced intestinal toxicity in PC patients. Therefore, the pri-let-7a-1 rs10739971 polymorphism could be used as a putative marker to predict the risk of intestinal toxicity in PC patients undergoing radiotherapy.
ORIENTASI NILAI BUDAYA BATAK TOBA, ANGKOLA DAN MANDAILING DALAM MEMBINA INTERAKSI DAN SOLIDARITAS SOSIAL ANTAR UMAT BERAGAMA DI TAPANULI UTARA (ANALISIS SOSIOLOGIS)
Authors: Firmando Harisan Boni 
Published: April 2021

<p><strong>Abstrak</strong></p><p>Masyarakat yang beragam sangat perlu dirawat keharmonisannya agar tidak menimbulkan kecurigaan, perbedaan pandangan yang mengarah pada kesalahpahaman, pertentangan dan berujung pada konflik. Sistem Kemasyarakatan <em>Dalihan na tolu</em> yang diorientasikan dalam nilai budaya masyarakat Batak Toba, Angkola dan Mandailing menjadi modal utama dalam membina interaksi dan solidaritas sosial antar umat beragama. Terjadinya silang budaya melalui adaptasi, akulturasi dan asimilasi antara masyarakat lokal dan pendatang menjadi cara dalam membina interaksi dan solidaritas social antar umat beragama di Tapanuli Utara. Metode yang digunakan dalam penelitian adalah metode deskriptif dengan pendekatan kualitatif. Data dikumpulkan dengan observasi dan wawancara. Unit analisis dan informasi adalah masyarakat lokal dan pedatang. Data ditafsirkan menggunakan catatan lapangan.</p><p> </p><p><strong>Kata Kunci : </strong><em>Nilai Budaya, Interaksi, Solidaritas Sosial</em><em></em></p><p><em> </em></p><p><strong><em>Abstract</em></strong><em></em></p><p><strong><em> </em></strong><em>Diverse society really needs to be maintained harmony so as not to arouse suspicion, differences in views that lead to misunderstanding, conflict and lead to conflict. The Dalihan na tolu Community System which is oriented in the cultural values </em><em></em><em>of the Batak Toba, Angkola and Mandailing communities is the main capital in fostering interaction and social solidarity between religious communities. The occurrence of cross culture through adaptation, acculturation and assimilation between local people and migrants is a way to foster interaction and social solidarity between religious communities in North Tapanuli. The method used in this research is descriptive method with a qualitative approach. Data collected by observation and interview. The unit of analysis and information is the local and migrant communities. Data are interpreted using field notes.</em></p><p> </p><strong><em>Keywords : </em></strong><em>Cultural Values, Interaction, Social Solidarity</em>
Joint cloud water path and rainwater path retrievals from airborne ORACLES observations
Authors: Dzambo Andrew M. , L'Ecuyer Tristan , Sinclair Kenneth , van Diedenhoven Bastiaan , Gupta Siddhant , McFarquhar Greg , O'Brien Joseph R. , Cairns Brian , Wasilewski Andrzej P. , Alexandrov Mikhail 
Published: April 2021

Abstract. This study presents a new algorithm that combines W-band reflectivity
measurements from the Airborne Precipitation Radar – third generation
(APR-3) passive radiometric cloud optical depth and effective radius
retrievals from the Research Scanning Polarimeter (RSP) to estimate total
liquid water path in warm clouds and identify the contributions from cloud
water path (CWP) and rainwater path (RWP). The resulting CWP estimates are
primarily determined by the optical depth input, although reflectivity
measurements contribute ∼10 %–50 % of the uncertainty due to
attenuation through the profile. Uncertainties in CWP estimates across all
conditions are 25 % to 35 %, while RWP uncertainty estimates frequently
exceed 100 %. Two-thirds of all radar-detected clouds observed during the ObseRvations of
Aerosols above CLouds and their intEractionS (ORACLES) campaign that took
place from 2016–2018 over the southeast Atlantic Ocean have CWP between 41
and 168 g m−2 and almost all CWPs (99 %) between 6 to 445 g m−2.
RWP, by contrast, typically makes up a much smaller fraction of total liquid
water path (LWP), with more than 70 % of raining clouds having less than 10 g m−2 of rainwater. In heavier warm rain (i.e., rain rate exceeding 40 mm h−1 or 1000 mm d−1), however, RWP is observed to exceed 2500 g m−2. CWP (RWP) is found to be approximately 30 g m−2 (7 g m−2) larger in unstable environments compared to stable environments.
Surface precipitation is also more than twice as likely in unstable
environments. Comparisons against in situ cloud microphysical probe data
spanning the range of thermodynamic stability and meteorological conditions
encountered across the southeast Atlantic basin demonstrate that the
combined APR-3 and RSP dataset enable a robust joint cloud–precipitation
retrieval algorithm to support future ORACLES precipitation susceptibility
and cloud–aerosol–precipitation interaction studies.
Structure, dynamics, and trace gas variability within the Asian summer monsoon anticyclone in the extreme El Niño of 2015–2016
Authors: Ravindra Babu Saginela , Venkat Ratnam Madineni , Basha Ghouse , Pani Shantanu Kumar , Lin Neng-Huei 
Published: April 2021

Abstract. A weak El Niño during 2014–2015 boreal winter developed as a strong
boreal summer event in 2015 which continued and even enhanced during the
following winter. In this work, the detailed changes in the structure,
dynamics, and trace gases within the Asian summer monsoon anticyclone (ASMA)
during the extreme El Niño of 2015–2016 is delineated by using Aura Microwave
Limb Sounder (MLS) measurements, COSMIC radio occultation (RO) temperature,
and National Centers for Environmental Prediction (NCEP) reanalysis products. Our analysis concentrates only on the summer
months of July and August 2015 when the Niño 3.4 index started to exceed values of 1.5. The results show that the ASMA structure was quite different in
summer 2015 as compared to the long-term (2005–2014) mean. In July, the
spatial extension of the ASMA is greater than the long-term mean in all
the regions except over northeastern Asia, where it exhibits a strong
southward shift in its position. The ASMA splits into two, and the western
Pacific mode is evident in August. Interestingly, the subtropical westerly
jet (STJ) shifted southward from its normal position over northeastern Asia,
and as a result midlatitude air moved southward in 2015. Intense Rossby wave
breaking events along with STJ are also found in July 2015. Due to these
dynamical changes in the ASMA, pronounced changes in the ASMA tracers are
noticed in 2015 compared to the long-term mean. A 30 % (20 %) decrease
in carbon monoxide (water vapor) at 100 hPa is observed in July over most of
the ASMA region, whereas in August the drop is strongly concentrated at the
edges of the ASMA. A prominent increase in O3 (> 40 %) at
100 hPa is clearly evident within the ASMA in July, whereas in August the
increase is strongly located (even at 121 hPa) over the western edges of the
ASMA. Further, the temperature around the tropopause shows significant
positive anomalies (∼ 5 K) within the ASMA in 2015. The present
results clearly reveal the El-Niño-induced dynamical changes caused
significant changes in the trace gases within the ASMA in summer 2015.
MANFAAT SKORING PROGNOSTIK DALAM PENENTUAN TATA LAKSANA KASUS METASTASIS OTAK
Authors: Diansari Yunni 
Published: April 2021

CLINICAL UTILITY OF PROGNOSTIC SCORES TO GUIDE THE MANAGEMENT OF BRAIN METASTASESABSTRACTMetastatic brain tumors are the most common intracranial neoplasms in adults and associated with significant morbidity and mortality. The current therapeutic options include surgery, whole brain radiation therapy (WBRT), stereotactic radiation (SRS), systemic therapy and symptom management only. The goals of brain metastasis management are giving longer survival, if possible the improvement in neurologic deficit and a better quality of life. Prognostic scores, a useful tool for BM patients, as an estimation of a patient’s prognosis can guide the tailored treatment for these patients. A more aggressive approaches is recommended in patients with good performance state with and controlled systemic disease. While palliative management is focused to patients on terminal state or with other comorbid disease. A number of prognostic scoring systems for BM patients have been proposed are Recursive Partitioning Analysis (RPA), the Score Index for Radiosurgery (SIR), the Basic Score for Brain Metastases (BSBM) and the Graded Prognostic Assessment (GPA). Recursive Partitioning Analysis and GPA are able to be implemented in brain metastatic patient in Indonesia.Keyword: Brain metastatic, prognostic scores, survival rateABSTRAKTumor otak metastasis merupakan tumor intrakranial yang paling sering dijumpai dan menyebabkan morbiditas serta mortalitas yang bermakna. Pilihan tata laksana terdiri dari tindakan bedah, whole brain radiation therapy (WBRT), sterotactic radiosurgery (SRS), terapi sistemik atau tata laksana simtomatik saja. Tujuan tata laksana pada pasien dengan metastasis otak adalah memperpanjang survival jika memungkinkan dengan mengontrol defisit neurologis dan memberikan kualitas hidup yang baik. Skoring prognostik merupakan metode yang bermanfaat pada kasus metastasis otak, karena dengan dapat memperkirakan prognosis pasien maka dapat menentukan pilihan tata laksana yang tepat. Tata laksana agresif direkomendasikan pada penderita dengan status performance yang baik dan penyakit sistemik yang terkontrol. Adapun tata laksana paliatif ditujukan pada pasien dengan kondisi terminal atau ada komorbid lain yang menyertai. Beberapa skoring prognostik telah diajukan seperti, Recursive Partitioning Analysis (RPA), Score Index for Radiosurgery (SIR), Basic Score for Brain Metastases (BSBM), dan Graded Prognostic Assessment (GPA). Recursive Partitioning Analysis dan GPA merupakan pilihan yang dapat diterapkan pada populasi pasien metastasis otak di Indonesia.Kata kunci: Metastasis otak, skoring prognostik, survival rate
MANIFESTASI NEUROPSIKIATRIK PADA LUPUS ERITEMATOSUS SISTEMIK DI RSUD DR. SOETOMO SURABAYA
Authors: Rana Nadya Rinda Eka , Awaliah Awalia , Hernaningsih Yetti , Hidayati Hanik Badriyah 
Published: April 2021

NEUROPSYCHIATRIC MANIFESTATION AMONG SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN GENERAL HOSPITAL SURABAYAABSTRACTIntroduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown causes and extensive clinical manifestations and diverse disease pathways. The clinical manifestations of SLE are very diverse, including the involvement of the nervous system and psychiatric syndrome (neuropsychiatric).Aims: To describe clinical neuropsychiatric manifestations of patients with SLE in Soetomo General Hospital Surabaya.Methods: This was a cross-sectional study based on medical record data on all SLE patients treated at Dr. Soetomo Hospital Surabaya, from January-December 2017. Neuropsychiatric manifestations assessment were based on the nomenclature of the American College of Rheumatology (ACR) in 1999.Results: There were 49 patients, mostly women (98%) with mean age 30,8±10,2 years old. Neurological manifestation was the 3rd most common diagnosis (43%) after hematologic disorder (73.5%) arthritis (53.1%). The manifestations of neuropsychiatric manifestation were mainly seizures (40.8%), headache (34.7%), cerebrovascular disease (26.5%), acute confusional state (20.4%), cognitive dysfunction (6.1%), and polyneuropathy (8.2%).Discussion: The most common neuropsychiatric clinical features in SLE patients are seizures, headache, cerebrovascular disease, and acute confusional state.Keywords: Lupus neuropsychiatry, prevalence, systemic lupus erythematosusABSTRAKPendahuluan: Lupus eritematosus sistemik (LES) merupakan penyakit inflamasi autoimun kronik yang belum diketahui penyebabnya dengan perjalanan penyakit yang luas. Manifestasi klinis LES sangat beragam, antara lain keterlibatan sistem saraf dan sindrom psikiatri (neuropsikiatri).Tujuan: Untuk mengetahui manifestasi neuropsikiatrik pasien dengan LES di RSUD Dr. Soetomo, Surabaya.Metodologi: Penelitian potong lintang berdasarkan data rekam medik terhadap semua pasien LES yang dirawat di RSUD Dr. Soetomo, Surabaya, pada bulan Januari hingga Desember 2017. Manifestasi neuropsikiatrik dinilain berdasarkan nomenklatur American College of Rheumatology (ACR) tahun 1999.Hasil: Didapatkan 49 subjek yang hampir semuanya (98%) adalah perempuan dengan rerata usia 30,8±10,2 tahun. Gangguan neurologis merupakan ketiga tersering (43%) setelah gangguan hematologi (73,5%) dan artritis (53,1%). Manifestasi neuropsikiatri terutama kejang (40,8%), nyeri kepala (34,7%), penyakit serebrovaskular (26,5%), keadaan konfusi akut (20,4%), dan polineuropati (8,2%).Diskusi: Manifestasi klinis neuropsikiatri yang paling banyak dialami oleh pasien LES adalah kejang, nyeri kepala, penyakit serebrovaskular, dan keadaan konfusi akut.Kata kunci: Lupus eritematosus sistemik, manifestasi klinis, neuropsikiatri
TUBERKULOMA SEREBRAL PADA PENDERITA ACQUIRED IMMUNE DEFICIENCY SYNDROME
Authors: Ongko Wijaya Vincent , Ardianto Dony , Sita Setya Pratiwi Gama , Mahendra Anton , Widra Shintyalola Glennis , Irfan Asany Rasi 
Published: April 2021

Tuberkuloma serebral merupakan komplikasi sistem saraf pusat yang jarang dan berbahaya akibat infeksi tuberkulosis (TB). Kondisi imunosupresif pada infeksi human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) merupakan faktor resiko dari perkembangan penyakit. Dilaporkan kasus seorang perempuan berusia 23 tahun dengan riwayat HIV/AIDS dan dalam pengobatan TB aktif dengan keluhan nyeri kepala dan pusing berputar sejak 1 minggu sebelum masuk rumah sakit. Pemeriksaan neurologis dalam batas normal. Pemeriksaan penunjang laboratorium menunjukkan penurunan kadar CD4 absolut dan dilanjutkan CT scan kepala dengan kontras. Pasien mendapat terapi utama deksametason, kotrimoksazol, dan obat anti tuberkulosis.
Kata kunci: HIV/AIDS, tuberkuloma, tuberkulosis
ROLE OF ABHYANGA IN JARA â€“ A REVIEW
Authors: Dike Rashmi Gajanan 
Published: April 2021

ABSTRACT
Ayurveda is a science of life which deals with preventive and curative aspects of the disease. . Jara is the natural and irreversible process of decaying and this manifested by various degenerative changes. In Vriddhavastha; Rasaraktadi Dhatu, Indriya, Bala etc.became Kshin. Aging related changes are noticeable from the 5th decade of life; among them skin related changes are mostly noticeable. Valli, Khalli , Twakparushata, diminished vision, Nidranasha are common problems of old age persons. In benefits of Abhyanga it was stated that, it prevents from the aging process by nourishing the Dhatus. In benefits of Padabhyanga, Acharya Vagbhata stated that it helps in improving vision. During Abhyang, serotonin released which helps in Nidranasha. So Abhyanga helps in prevention of Jara
LIFE AFTER DEATH-THE HUMAN ORGANS TRANSPLANTATION ACT A REVIEW
Authors: Mane Jyoti Chandrashekhar 
Published: April 2021

ABSTRACT: -
We all have been hearing, reading and seeing many issues regarding organ transplantation, but many people are not aware and serious regarding Human organ transplant. Many patients struggle for life after failure of functioning of some major organs. A patient with a case of renal failure can survive for some period with the help of advance technique Viz. Dialysis, but patients with failure of function of liver or Heart etc. have no substitute for Human Organ Transplant. It is a small effort to encourage and create awareness in people to promote organ transplant. In last 10 years people are much aware regarding organ donation and organ transplant. The person certified as brain dead can only donate his healthy organs to a needy and increase his life span [2]. In India we can see advancement in the field of transplantation. The law regarding Human Organ Transplant was passed in the year 1994 it came into force in 1995[1]This law includes Regulations regarding removal, preservation and transplantation of organ for treatment purpose and prevention of commercialization of human organs[1