bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of Mineral Crystallization at Different Stages of the Magmatism Evolution of the Gorely Volcano (Kamchatka): Data on Melt and Fluid Inclusions
Authors: Simonov V.A. , Dobretsov N.L. , Kotlyarov A.V. , Karmanov N.S. , Borovikov A.A. 
Published: April 2021

Abstract
––Studies of melt and fluid inclusions and minerals as well as computational modeling (based on the data on the composition of melt inclusions, clinopyroxenes, and amphiboles) gave an insight into the physicochemical parameters of magmatic systems during the evolution of the precaldera Pra-Gorely Volcano and during the subsequent formation of rock complexes of the Young Gorely Volcano. The estimated temperatures of crystallization of olivine, clinopyroxene, and plagioclase phenocrysts (1115–1260 °С) and amphibole (740–890 °С) are in agreement with the earlier published data on the magmatism of the Gorely Volcano. Computational modeling based on the compositions and homogenization temperatures of melt inclusions showed that the established depth interval of mineral crystallization (21.0–1.5 km) with pressures of 7.0–0.5 kbar can be divided into two ranges, 21–15 km and 9.0–1.5 km. Both the Pra-Gorely and Young Gorely volcanoes have magma chambers in these depth ranges. The Pra-Gorely Volcano is characterized by higher temperatures of mineral crystallization (1240–1190 °С) as compared with the Young Gorely Volcano (1190–1125 °С). The presence of primary fluid inclusions with low-density CO2 and of syngenetic primary melt inclusions in plagioclase of the Pra-Gorely Volcano indicates that the mineral crystallized from a heterophase melt. At the same time, the cores of plagioclase phenocrysts formed from a homogeneous melt. A drastic drop in pressure led to the phase separation of magma throughout the magma column (upper and lower chambers) and to the growth of zones saturated with CO2 fluid inclusions in the plagioclase crystals formed from a two-phase melt. The subsequent closure of the system and the disappearance of CO2 phase resulted in the growth of plagioclase from a homogeneous melt.
Quantitative Hydraulic-Fracture Geometry Characterization with LF-DAS Strain Data: Numerical Analysis and Field Applications
Authors: Liu Yongzan , Jin Ge , Wu Kan , Moridis George 
Published: April 2021

Abstract
Low-frequency distributed acoustic sensing (LF-DAS) has been used for hydraulic fracture monitoring and characterization. Large amounts of DAS data have been acquired across different formations. The low-frequency components of DAS data are highly sensitive to mechanical strain changes. Forward geomechanical modeling has been the focus of current research efforts to better understand the LF-DAS signals. Moreover, LF-DAS provides the opportunity to quantify fracture geometry. Recently, Liu et al. (2020a;2020b) proposed an inversion algorithm to estimate hydraulic fracture width using LF-DAS data measured during multifracture propagation. The LF-DAS strain data is linked to the fracture widths through a forward model developed based on the Displacement Discontinuity Method (DDM). In this study, we firstly investigated the impacts of fracture height on the inversion results through a numerical case with a four-cluster completion design. Then we discussed how to estimate the fracture height based on the inversion results. Finally, we applied the inversion algorithm to two field examples.
The inverted widths are not sensitive to the fracture height. In the synthetic case, the maximum relative error is less than 10% even when the fracture height is two times of the true value. After obtaining the fracture width, the fracture height can be estimated by matching the true strain data under various heights with a strong smooth weight. The error between the calculated strain and true strain decreases as the height is getting close to the true value. In the two field examples, the temporal evolutions of both width summation of all fractures and the width of each fracture show consistent behaviors with the field LF-DAS measurements. The calculated strain data from the forward model matches well with the field LF-DAS strain data. The results demonstrate the robustness and accuracy of the proposed inversion algorithm.
Digital Fracture Characterization at Hydraulic Fracturing Test Site HFTS-Midland: Fracture Clustering, Stress Effects and Lithologic Controls
Authors: Maity Debotyam , Ciezobka Jordan 
Published: April 2021

Abstract
In this case study, we apply a novel fracture imaging and interpretation workflow to take a systematic look at hydraulic fractures captured during thorugh fracture coring at the Hydraulic Fracturing Test Site (HFTS) in Midland Basin. Digital fracture maps rendered using high resolution 3D laser scans are analyzed for fracture morphology and roughness. Analysis of hydraulic fracture faces show that the roughness varies systematically in clusters with average cluster separation of approximately 20' along the core. While isolated smooth hydraulic fractures are observed in the dataset, very rough fractures are found to be accompanied by proximal smoother fractures. Roughness distribution also helps understand the effect of stresses on fracture distribution. Locally, fracture roughness seems to vary with fracture orientations indicating possible inter-fracture stress effects. At the scale of stage lengths however, we see evidence of inter-stage stress effects. We also observe fracture morphology being strongly driven by rock properties and changes in lithology. Identified proppant distribution along the cored interval is also correlated with roughness variations and we observe strong positive correlation between proppant concentrations and fracture roughness at the local scale. Finally, based on the observed distribution of hydraulic fracture properties, we propose a conceptual spatio-temporal model of fracture propagation which can help explain the hydraulic fracture roughness distribution and ties in other observations as well.
The Path in Behind and the Challenges in Front: A Methodological Synthesis of Iranian L2 Papers
Authors: Jahanbakhsh Akbar A. , Ajideh Parviz 
Published: April 2021

Abstract
The present study is a methodological synthesis aiming to evaluate the adherence of Iranian L2 papers to the study quality standards. Ten Iranian journals were selected based on the latest ranking of Iran’s Ministry of Science, Research, and Technology (MSRT), and all experimental papers (N = 367) published from their beginnings were explored for study quality with regards to sampling, design, statistical tests, reporting practices and data sharing, and visual presentation. In the evaluation of the papers, the protocols proposed by Gass and Plonsky (2011) and Pagout and Plonsky (2017) were moderated and some recent issues proposed by APA’s (2018) Journal Article Reporting Standards and some scholars (e.g., Hu & Plonsky, 2019; Khany & Tazik, 2019; Larson-Hall, 2017) were added. The results showed that while there were issues, like acceptable sample size, use of pre-testing, reporting descriptive and inferential statistics, and ensuring the reliability of instruments, that were acceptably adhered to quality standards, problematic areas existed in all five facets of quality, and the majority of them stayed constant or changed slightly over time. The shortcomings caused by such lack of adherence are discussed to identify the challenges in the way of improving the papers’ quality. Although the results are obtained from a specific context, the implications may be generalizable to other contexts where English is taught and researched as a foreign language.
Giant Genital Condyloma Acuminatum: A case report
Authors: Thakor Poojan , Badgurjar Mohit Kumar , Prajapati Giriraj , Saxena Pankaj , Parihar Suman 
Published: April 2021

Abstract
The giant condyloma acuminatum(GCA),also known as Buschke–Löwenstein tumor(BLT),is a type of human papilloma virus associated sexually transmitted infection. Various treatment options are available but best option amongst them is surgery. This case report present a GCA case in male with masses over lower abdomen and penile region where surgical resection is done, taking into account the high rate of recurrence and the significant potential of malignant transformation.
Experimental Investigation and Multi-Objective Optimization of Cryogenically Cooled Near-Dry Wire-Cut EDM Using TOPSIS Technique
Authors: Sampath Boopathi , Myilsamy Sureshkumar , Sukkasamy Sudhager 
Published: April 2021

Abstract
In this research, the mixing of compressed air with the minimum quantity of water is used as a dielectric medium and the cryogenically cooled molybdenum wire is used as a tool in wire-cut electrical discharge machining (WEDM) to encourage the eco-friendly production, called cryogenically cooled near-dry WEDM process. The nitrogen gas-cooled wire tool is utilized to cut the Inconel 718 alloy workpiece to prevent wire breakage and maintain enough electrical conductivity. The preliminary experiments were conducted to compare wet, dry, near-dry, and cryogenically cooled near-dry WEDM processes. It was revealed that cryogenic cooled near-dry WEDM is better performance than dry, near-dry WEDM except for the wet process. The systematic experiments of eco-friendly cryogenically cooled near-dry WEDM have been conducted to analyse the effect of input factors like spark current, pulse-width, pulse-interval, and mixing water flow rate on material removal rate (MRR) and surface roughness (SR) using Box–Behnken method. The fitted models and response surface graphs were developed to analyse the influences of input factors on each response parameter. It was concluded that MRR and SR of cryogenically cooled near-dry WEDM are increased by maximizing spark current, pulse-width, and flow rate, conversely, both responses were decreased by increasing pulse-interval. The technique for order of preference by similarity to ideal solution (TOPSIS) technique has been applied to predict the best combination of input factors for satisfying the optimal values of both responses.
In - Vivo Conversion of Astrocytes to Neuroblasts in the Injured Spinal Cord
Authors: Ataei Maryam Lale , Karimipour Mohammad , Shahabi Parviz , Soltani-Zangbar Hamid , Pashaiasl Maryam 
Published: April 2021

Abstract
Direct astrocyte reprogramming to neural progenitor cells and promotion of neurogenesis is considered as an alternative approach to replace the lost neurons in the spinal cord injury(SCI). Herein, we used the human amniotic fluid mesenchymal stem cells (hAF-MSCs) and their conditioned medium (CM), to investigating their ability to reprogramming astrocytes to neuroblasts following SCI. 54 adult rats were randomly divided into 9 groups (n = 6), included: Control, SCI, (SCI + DMEM), (SCI + CM), (SCI + MSCs), (SCI + Astrocyte), (SCI + Astrocyte + DMEM), (SCI + Astrocyte + CM) and SCI + Astrocyte + MSCs). Following laminectomy and SCI induction, DMEM, CM, MSCs and Astrocytes were injected. Wester-blot was performed to explore the levels of the Sox2 protein in the MSCs-CM. The immunofluorescence staining against DCX and GFAP was done. Finally, Basso-Beattie-Brenham (BBB) locomotor test was conducted to assess the neurological outcomes. Our results showed that the MSCs through juxtacrine and paracrine mechanisms induced the promotion of the endogenous neuroblasts and the decline of astrocytes. Moreover, in the present research, MSCs and CM could convert the transplanted human astrocytes to neuroblasts in the spinal cord injury. Taken together, our data indicate the MSCs via juxtacrine and paracrine pathways could direct the spinal cord endogenous neural stem cells(NSCs) to the neuroblasts lineage rather than astrocytes as well as induce reprogramming. Ultimately, MSCs could reverse the neurobehavioral deficit in the SCI. The striking output in our study was the capability of the MSCs in the reprogramming of the astrocytes to neuroblasts via juxtacrine and paracrine pathways in the In-vivo condition.
Epigenetic Regulation in Myelodysplastic Syndrome as A Consequence of A MicroRNA Dysregulation.
Authors: Avenoso Daniele , Squillario Margherita , Barla Annalisa , Verri Alessandro , Carminati Enrico , Nurra Clara , Todisco Elisabetta , Gigli Federica , Bertolini Francesco , Gregato Giuliana , Poletti Claudia , Miglino Maurizio 
Published: April 2021

Abstract
The myelodysplastic syndromes are a group of diseases characterized by impairment in hemopoiesis and variable tendency to progress to acute myeloid leukemia. Recent data regarding the MDS pathogenesis highlight alterations in several compartments of DNA replication, cell cycle control, and gene expression machinery. As previously reported, miRNA families are involved in MDS pathogenesis. Also, different miRNAs have been characterized in AML and MDS and allow the identification of prognostic risk categories independent from the revised international prognostic scoring system (R-IPSS). Herein we report the results and the possible scenarios regarding pathogenesis and disease progression secondary to the evidence of considerable gene network derangement following miRNA evaluation in a cohort of patients.
Long-Term Outcomes of Initial Trabeculectomy in Glaucoma Associated with Granulomatous and Non-Granulomatous Uveitis
Authors: Almobarak Faisal A. , Alharbi Ali H. , Aljadaan Ibrahim , Aldhibi Hassan 
Published: April 2021

Abstract
Purpose

To evaluate the outcomes of initial trabeculectomy in granulomatous and non-granulomatous uveitis.
Methods

Retrospective comparative study of 68 eyes that underwent an initial trabeculectomy.
Results

The mean follow-up was 74.18 and 74.86 months in both groups (p = 0.95). The intraocular pressure decreased from 40.03 mmHg (± 7.2) and 36.48 mmHg (± 11.3) to 14.00 mmHg (± 6.2) and 13.48 mmHg (± 5.7), the number of medications decreased from 3.73 (± 0.7) and 3.58 (± 0.9) to 1.00 (± 1.4) and 1.13 (± 1.4) on the last follow-up (p < 0.01) in the granulomatous and non-granulomatous groups, respectively. More eyes in the granulomatous uveitis group developed delayed postoperative complications like cataract, transient hypotony and glaucoma progression. Success rates were 64.9 and 71.0%, while failure rates were 35.1 and 29.0% in both groups (p = 0.84).
Conclusions

Trabeculectomy seems to have comparable IOP control and survival in granulomatous and non-granulomatous uveitis. Nevertheless, more eyes in the granulomatous uveitis group developed late onset complications.
Composition and Diversity of Endophytic Bacterial Community in Seeds of Upland Rice Resources from Different Origin Habitats in Yunnan Province of China
Authors: Wang Zhishan , Zhu Yongqiang , Li Ni , Sun Biqi , Liu Hai , Zheng Huajun , Wang Weiping , Liu Yang 
Published: April 2021

Abstract
Upland rice has the characteristics of strong drought tolerance and wide adaptability. Cultivating upland rice with high yield and high quality can solve the contradiction between food shortage, water shortage, and population increase in countries all over the world, and is of great significance to the sustainable development of agriculture. This study aims to reveal the "core microbiota" of the endophytic bacteria in upland rice seeds in the Yunnan Province of China by examining their diversity and community structures. Through the correlation analysis with upland rice habitat environmental factors, the effects of climate and altitude on the structure and diversity of endophytic bacterial community in upland rice seeds were further revealed. In this study, high-throughput sequencing technology based on the Illumina Miseq platform was used to investigate the structure and diversity of endophytic bacterial communities using 12 upland rice variety seeds from different areas in Yunnan Province of China as materials. Here, 39 endophytic OTUs (0.68%) were found to coexist in all samples. At the phylum level, the first dominant phyla in the 12 seed samples were Proteobacteria (66.92–99.98%). At the genus level, Pantoea (9.75–99.24%), Pseudomonas (0.11–37.24%), Curtobacterium (0.01–19.90%), Microbacterium (0.01–14.95%), Methylobacterium (0.40–5.86%), Agrobacterium (0.01–4.53%), Sphingomonas (0.04–1.56%), Aurantimonas (0.01–1.45%) and Rhodococcus (0.11–1.09%), which represent the core microbiota in upland rice seeds, served as the dominant genera that coexisted in all the upland rice seeds tested. Environmental factors such as temperature, precipitation and altitude have great influences on the structure of endophytic bacterial community in upland rice seeds. This study is of great significance to explore the relationship between upland rice and its endophytic bacteria and to tap the resources of drought-tolerant bacteria to improve the yield of local upland rice.
Dysglyceamia after COVID-19 pneumonia: a six-month cohort study.
Authors: Molinari Chiara , Laurenzi Andrea , Caretto Amelia , Rovere-Querini Patrizia , Ciceri Fabio , Lampasona Vito , Scavini Marina , Piemonti Lorenzo 
Published: April 2021

Abstract
Aim. The aim of this study was to understand whether the dysglyceamia associated with SARS-CoV-2 infection persists or reverts when the viral infection resolves. Methods. We analyzed fasting blood glucose (FBG) after hospital discharge in a cohort of 621 adult cases with suspected COVID-19 pneumonia. Results. At admission,, 18.8% of the patients in our cohort had pre-existing diabetes, 9.3% fasting glucose in the diabetes range without a prior diagnosis (DFG), 26% impaired fasting glucose (IFG), 44.9% normal fasting glucose (NFG), while 2% had no FBG available. FBG categories were similarly distributed in the 71 patients without confirmed COVID-19 pneumonia. During follow up (median time 6 month) FBG was available for 321 out of the 453 (70.9%) surviving patients and showed a trend to a marginal increase [from 97 (87–116) to 100 (92–114) mg/dL; p = 0.071]. Transitions between FBG categories was analysed in subjects without pre-existing diabetes (265 out of 321). We identified three groups: i) patients who maintained or improved FBG during follow-up [Group A, n = 185; from 100 (86–109) to 94 (88–99) mg/dL; p < 0.001]; ii) patients who moved from the NFG to IFG category [Group B, n = 66: from 89 (85–96) to 106 (102–113) mg/dl; p < 0.001]; iii) patients who maintained or reached DFG during follow-up [Group C, n = 14: from 114 (94–138) to 134 (126–143) mg/dl; p = 0.035]. Male sex and ICU admission during the hospitalization were more prevalent in Group C compared to Group A or B. Conclusions. Six months after the SARS-CoV-2 infection DFG was evident in only few patients who experienced severe COVID-19 pneumonia.
Escherichia Coli Isolate From Hospital Sewage Is Carrying blaNDM-1 and blaoxa-10
Authors: Hu Zimeng , Chen Weiye , Guo Genglin , Dong Chen , Shen Yun , Qin Si , Chen Long , Zhang Wei 
Published: April 2021

Abstract
Carbapenems, as the “last line of defense” against gram-negative bacteria, are increasingly being challenged by drug-resistant bacteria, especially in Enterobacteriaceae. In this study, a carbapenems resistant gram-negative bacterium, named AH001, was isolated from hospital sewage, and modified Hoge test confirmed this bacterium can produce carbapenemase. Further analysis revealed that this bacterium is multi-drug resistance, which against additional seven antibiotics. Whole-genome sequencing and analysis showed that AH001 could not be classified by existing MLST, and its serotype couldn’t be distinguished among O9, O89 or O168 in O antigen prediction. More attention should be paid to the role of environmental source Escherichia coli in the development and transfer of drug resistance in the hospital environment.
Chaperonin Point Mutation Enhances Cadmium Endurance in Saccharomyces Cerevisiae
Authors: Dube Ankita , Kabir M Anaul 
Published: April 2021

Abstract
Objective:

To study the effect of the mutation in conserved G412E in Cct7p subunit of CCT complex on its cellular fate.
Results:

TriC/CCT is a dynamic multimeric protein that assists in protein folding in energy-dependent manner. A point mutation in the ATP binding pocket in the equatorial domain of Cct7p subunit causes a delay in doubling time. The cell’s size was twice the wild type, and the formation of protein aggregates suggests disturbed folding of the proteins. Upon growing in stressful conditions of arsenous acid and cadmium chloride, mutant was found to be lethal in As3+ but grew well in Cd2+ with 10.59µg cadmium uptake mg− 1 compared to wild type. The increased expression of vacuole transporters YCF1 and BPT1 by ten-fold and two-fold in mutant indicates the metal transportation to the vacuole.
Conclusion:

CCT complex was vulnerable to the mutation in G412E in Cct7p subunit of protein folding molecular machinery. Interestingly, already stressed cells provided robustness against oxidative stress and cadmium sequestration in the vacuole.
Design and analysis of highly sensitive solid core gold-coated hexagonal photonic crystal fiber sensor based on surface plasmon resonance
Authors: Kiroriwal Monika , Singal Poonam 
Published: April 2021

Abstract
In this article, a surface plasmon-based hexagonal photonic crystal fiber sensor is numerically computed and studied. Metallic layer thickness and lattice period are optimized to 30 nm and 1.75 µm respectively to enhance the sensor performance. Sensor sensitivity is obtained by employing the finite element method by enclosing the structure with a perfectly matched layer. This studied sensor uncovers the wavelength sensitivity of 8000nm/RIU, amplitude sensitivity of 3959 /RIU, and minimum detection ability of 1.25x10− 5 RIU for the analyte refractive index range from 1.36 to 1.40. The simulated results’ variations are also analyzed by altering the metallic layer thickness, lattice period, and air hole diameter. The computed PCF sensor might be a promising aspirant in the area of chemical sensing, bio-molecule detection, and biological sample recognition.
Modelling Past and Future Urban Ecosystem Health Assessment —A Case Study of Kunming
Authors: Li Hui , Liu Yang , Sheng Weiguo , Qiu Huiyi , Zhou Yilu , Huang Xue , Chen Yanming , Li Mengran 
Published: April 2021

Abstract
Rapid urbanisation leads to increasing conflict in the human-environment relationship. The health of urban ecosystems is deteriorating and this will directly harmcommunity health and wellbeing. This paper used Kunming, the capital city of Yunnan Province, China as a case study. A health assessment model for the urban ecosystem of Kunming was built using 25 indicators reflecting five measures: driving force, pressure, state, impact and response. We calculated the indicator values in 2006, 2011 and 2016 with remote sensing and statistical data. We used the entire-array-polygon method to draw polygon graphs and calculate the overall indicator values of the three periods, based on the standardised values of all indicators. All the indicator values were below 0.25, showing that the urban ecosystem was assessed as unhealthy. On the basis of the past health assessment model, we applied a grey system forecasting method to predict the future health of the urban ecosystem. If the current trends continued, the urban ecosystem would remain in an unhealthy state for 5–10 years. Strong measures should be implemented to improve the overall health of the urban ecosystem. This paper serves as an early warning of the health state of the urban ecosystem in Kunming.