bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Perception of Pain Control (Not Opiate Amount) Affects Hospital Consumer Assessment of Healthcare Providers and Systems and Press Ganey Satisfaction Scores After Orthopaedic Trauma
Authors: Ahmed Adil S. , Kim Ryan L. , Ramsamooj Harry , Roberts Michael , Downes Katheryne , Mir Hassan R. 
Published: January 2021

Introduction:
Opiate abuse is a public health issue linked to prescribing. Prescribing increased partly in response to adopting pain as the fifth vital sign. Assessing pain control on patient satisfaction surveys, including government-mandated Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) and optional private surveys (Press Ganey) administered on hospital discharge, may contribute. This study evaluates whether opiate amounts affect orthopaedic trauma patient perception of pain control and overall hospital rating on HCAHPS and Press Ganey surveys.

Methods:
Consecutive adult patients >18 years surgically treated for isolated fractures (UE = upper extremity, LE = lower extremity, and PA = pelvis/acetabulum) at a level 1 trauma center between January 1, 2014, and December 31, 2016, were retrospectively analyzed. Hospital charts, HCAHPS, and Press Ganey data were reviewed; patients without survey responses were excluded. Data included comorbidities, psychiatric history, substance use, injury type, and surgery. Analysis included Spearman's rho for correlations, Wilcoxon rank-sum and Kruskal-Wallis for continuous variables, and adjusted ordinal regression to estimate association between opioid prescribing and patient ratings.

Results:
One hundred fifty-two total patients (UE 29, LE 112, and PA 11) with mean age of 57 years and median length of stay 3 days were included. Adjusted models showed longer duration outpatient prescriptions were associated with lower rating on how often inpatient pain was controlled (P = 0.002), lower total MME inpatient was associated with higher ratings (HCAHPS P = 0.015; Press Ganey, P = 0.03), lower average daily MME inpatient was associated with lower ratings (HCAHPS P = 0.008; Press Ganey, P = 0.037), and shorter outpatient prescription duration was associated with lower ratings (P = 0.008). Patient perception of pain control was strongly associated with overall HCAHPS (P < 0.05) and Press Ganey (P < 0.001) ratings.

Discussion:
Inpatient and outpatient opiate amounts and duration demonstrated some associations with overall scores. However, patients' pain control perception seems to have the strongest relationship with hospital rating. Counseling and multimodal pain control may lead to strong satisfaction scores without needing high opiates after orthopaedic trauma.
Total Knee Arthroplasty in Freestanding Ambulatory Surgery Centers: 5-Year Retrospective Chart Review of 90-Day Postsurgical Outcomes and Health Care Resource Utilization
Authors: Mascioli Anthony A. , Shaw Marian L. , Boykin Shawn , Mahadevan Prakash , Wilder J. Heath , Bell J. Weston , Dabov Gregory D. , Toy Patrick C. 
Published: January 2021

Introduction:
Migration of total knee arthroplasty (TKA) procedures from the inpatient setting to outpatient venues, especially freestanding ambulatory surgery centers (ASCs), requires the use of reliable patient selection algorithms and standardized perioperative pathways to facilitate favorable outcomes for patients.

Methods:
This retrospective chart review included consecutive TKA procedures performed over a 5-year period between January 2014 and January 2019 at 2 freestanding ASCs. The patient selection algorithm was developed on the basis of patient comorbidities to minimize the potential for adverse events. All procedures were performed by one of eight orthopedic surgeons who were identified a priori as adhering to similar multimodal pain management regimens, including the use of spinal anesthesia, general or monitored-care anesthesia, adductor canal blocks, pericapsular injection of liposomal bupivacaine, nonsteroidal anti-inflammatory drugs, gabapentin, tramadol, acetaminophen, and oxycodone on an as-needed basis. Outcomes, including surgical complications, healthcare resource utilization (HCRU), and patient satisfaction, were measured before discharge and at a 90-day follow-up visit.

Results:
Four hundred thirty-nine TKA procedures in 386 patients were identified for inclusion. Of these patients, 115 (29.8%) were performed in patients with the American Society of Anesthesiologists physical status IIIa. Mean (standard deviation) length of stay at the ASC was 500 (107) minutes, including 136 (47) minutes of surgery and 201 (78) minutes to ambulation. The overall rates of surgical complications and 90-day hospital admissions were low (1.4% and 0.7%, respectively), as was the need for additional HCRU, including additional surgical procedures related to index surgery, emergency department visits, and unplanned clinic visits or calls. At the 90-day follow-up visit, 96% of patients reported being pleased with their outcomes.

Discussion:
With careful patient selection, standardized perioperative pathways, and multimodal analgesia protocols, TKA procedures can be performed in the ASC setting with low complication rates, minimal postdischarge HCRU, and high rates of patient satisfaction.

Level of evidence:
III
Implicaciones de la gamificación en Educación Superior: una revisión sistemática sobre la percepción del estudiante
Authors: Pegalajar Palomino Mª del Carmen 
Published: January 2021

Este trabajo realiza una revisión sistemática para identificar los principales hallazgos reportados en la literatura científica sobre la percepción del estudiante universitario hacia la práctica de estrategias de gamificación en su proceso de aprendizaje. La búsqueda documental se ha llevado a cabo a partir de la triangulación de las publicaciones incluidas en las bases de datos “Web of Science” y “Scopus” durante el período 2010-2019. Tras aplicar los criterios de selección y calidad, se han identificado un total de 20 estudios como muestra final. Los resultados demuestran el interés creciente de la comunidad científica por plantear trabajos sobre gamificación en Educación Superior. Además, se corrobora una predisposición favorable en el alumnado hacia el desarrollo de experiencias didácticas innovadoras basadas en la gamificación. Entre sus potencialidades, destaca el aumento de la motivación, el interés y la participación del alumnado en el proceso de enseñanza-aprendizaje, así como la mejora del rendimiento académico y el desarrollo de las habilidades y competencias necesarias para su desarrollo profesional.
This work performs a systematic review to identify the main findings reported in the scientific literature on the perception of the university student towards the practice of gamification strategies in their learning process. The documentary search was carried out based on the triangulation of the publications included in the "Web of Science" and "Scopus" databases during the period 2010-2019. After applying the selection and quality criteria, a total of 20 studies have been identified as the final sample. The results demonstrate the growing interest of the scientific community to propose works on gamification in Higher Education. Furthermore, a favorable predisposition in the students towards the development of innovative didactic experiences based on gamification is corroborated. Among its potential, the increase in motivation, interest and participation of students in the teaching-learning process stands out, as well as improving academic performance and developing the skills and competences necessary for their professional development
Acoso escolar y autoconcepto en personas trans
Authors: Pérez Fernández Pablo Daniel , Fernández Rodríguez María , García Vega Elena , Guerra Mora Patricia 
Published: January 2021

Introducción: El acoso escolar es un fenómeno presente en todos los centros escolares y sus consecuencias sobre la salud mental de las víctimas pueden ser muy importantes. Las personas trans viven muchas veces con un estigma social que las hace más proclives a sufrir discriminación. El objetivo de este estudio es analizar las características del acoso escolar en personas trans y su relación con el autoconcepto, así como establecer una comparación con un grupo control cisgénero.
Método: La muestra estuvo compuesta por 68 participantes. El grupo experimental estuvo compuesto por 34 personas trans. El grupo control estuvo compuesto por 34 personas de características sociodemográficas similares.
Resultados: La prevalencia del acoso escolar es del 20,1% en personas trans. No hay diferencias significativas en acoso escolar respecto al grupo control. Tampoco se encontraron diferencias respecto al autoconcepto ni otras variables sociodemográficas.
Conclusiones: Nuestros resultados no apoyan la idea, señalada por otros autores, de que las personas trans experimentan mayor acoso escolar ni un menor autoconcepto. Se ha hallado que reciben más agresiones basadas en objetos y maltrato físico que las personas cisgénero acosadas.
Introduction. Bullying is a phenomenon present in all schools and its consequences on the mental health of victims can be very important. Trans people often live with a social stigma that makes them more prone to discrimination. The objective of this study is to analyze the characteristics of bullying in trans people and its relationship with self-concept, as well as to establish a comparison with a cisgender control group.
Method: The sample was made up of 68 participants. The experimental group was made up of 34 trans people. The control group was made up of 34 people with similar sociodemographic characteristics.
Results: The prevalence of bullying is 20.1% in trans people. There are no significant differences in bullying compared to the control group. There were also no differences regarding self-concept or other sociodemographic variables.
Conclusions: Our results do not support the idea, pointed out by other authors, that trans people experience more bullying or less self-concept. They have been found to receive more object-based assaults and physical abuse than harassed cisgender people
Inclusive education and labour insertion from a capabilities approach: a phenomenological and functional diversity perspective
Authors: Zárate-Rueda Ruth , Murallas-Sánchez Daniella , Ortega-Zambrano Catalina 
Published: January 2021

El estudio se enfoca en el análisis de experiencias de vida en los ámbitos académico y labo-ral de egresados con diversidad funcional de la Universidad Industrial de Santander-UIS. La investigación se desarrolla desde el paradigma interpretativo y el enfoque fenomenológico para dimensionar las experiencias vividas y sentidas durante y después de su paso por la universidad; asimismo, los resultados se validan mediante la triangulación por contraste de información entre teoría, realidad e investigador. Los resultados señalan que las barreras arquitectónicas y psicosociales son un impedimento para atender las necesidades diferenciales de los estudiantes desde la inclusión educativa; además, se encontró que el mercado laboral no ofrece oportunidades incluyentes y la participación es limitada; con lo cual se concluye que existen brechas en el acceso a educación y trabajo, igualdad de oportunidades y respeto por las diferencias. Finalmente, se denota que la implementación de la Política de Educación Inclusiva universitaria es imperante para vincular a este segmento de población, específicamente con procesos que integren el enfoque de capacidades y el Enfoque de Derechos Humanos.
This study focuses on the analysis of life experiences in the academic and work environmentof professionals with functional diversity graduated from the Universidad Industrial de Santander-UIS. Our research has been conducted under the interpretative paradigm and usesa phenomenological approach in order to evaluate the participants’ lived and felt experiencesduring and after their time at university. Our results have been validated through the use oftriangulation, contrasting the information gathered from theory, reality and researchers. Theresults indicate that architectural and psychosocial barriers are an obstacle to the differentialneeds of students from the perspective of inclusive education; besides, it has been found thatthe labour market does not offer inclusive opportunities, and participation is limited. This hasled us to conclude that there are gaps in access to education and work regarding equal opportunitiesand the respect for differences. Finally, we note that the implementation of InclusiveEducation Policies at university is essential for the integration of this demographic, specificallyin processes that combine the Capabilities and Human Rights approaches.
Tumor microenvironment related novel signature predict lung adenocarcinoma survival
Authors: Chen Juan , Zhou Rui 
Published: January 2021

Background
Lung adenocarcinoma (LUAD) is the most common histological type of lung cancers, which is the primary cause of cancer‐related mortality worldwide. Growing evidence has suggested that tumor microenvironment (TME) plays a pivotal role in tumorigenesis and progression. Hence, we investigate the correlation of TME related genes with LUAD prognosis.

Method
The information of LUAD gene expression data was obtained from The Cancer Genome Atlas (TCGA). According to their immune/stromal scores calculated by the ESTIMATE algorithm, differentially expressed genes (DEGs) were identified. Then, we performed univariate Cox regression analysis on DEGs to obtain genes that are apparently bound up with LUAD survival (SurGenes). Functional annotation and protein-protein interaction (PPI) was also conducted on SurGenes. By validating the SurGenes with data sets of lung cancer from the Gene Expression Omnibus (GEO), 106 TME related SurGenes were generated. Further, intersection analysis was executed between the 106 TME related SurGenes and hub genes from PPI network, PTPRC and CD19 were obtained. Gene Set Enrichment Analysis and CIBERSORT analysis were performed on PTPRC and CD19. Based on the TCGA LUAD dataset, we conducted factor analysis and Step-wise multivariate Cox regression analysis for 106 TME related SurGenes to construct the prognostic model for LUAD survival prediction. The LUAD dataset in GEO (GSE68465) was used as the testing dataset to confirm the prognostic model. Multivariate Cox regression analysis was used between risk score from the prognostic model and clinical parameters.

Result
A total of 106 TME related genes were collected in our research totally, which were markedly correlated with the overall survival (OS) of LUAD patient. Bioinformatics analysis suggest them mainly concentrated on immune response, cell adhesion, and extracellular matrix. More importantly, among 106 TME related SurGenes, PTPRC and CD19 were highly interconnected nodes among PPI network and correlated with immune activity, exhibiting significant prognostic potential. The prognostic model was a weighted linear combination of the 106 genes, by which the low-OS LUAD samples could be separated from the high-OS samples with success. This model was also able to rebustly predict the situation of survival (training set: p-value < 0.0001, area under the curve (AUC) = 0.649; testing set: p-value = 0.0009, AUC = 0.617). By combining with clinical parameters, the prognostic model was optimized. The AUC achieved 0.716 for 3 year and 0.699 for 5 year.

Conclusion
A series of TME-related prognostic genes were acquired in this research, which could reflect immune disorders within TME, and PTPRC and CD19 show the potential to be an indicator for LUAD prognosis and tumor microenvironment modulation. The prognostic model constructed base on those prognostic genes presented a high predictive ability, and may have clinical implications in the overall survival prediction of LUAD.
Design and Validation of an Assessment Tool for Educational Mobile Applications Used with Autistic Learners
Authors: Sanromà-Giménez Mònica , Lázaro Cantabrana José Luis , Usart Rodríguez Mireia , Gisbert-Cervera Mercè 
Published: January 2021

Abstract
This work presents the design and validation process for a tool to evaluate educational mobile applications for autistic learners. The project was developed in several stages. First, we reviewed and analysed the literature. Second, we conducted a Delphi study with experts (n=12) from different backgrounds (educational technology, accessibility, app developers and autism specialist teachers) selected using the calculated expert competence coefficient. And finally, we conducted a pilot test with trainee (n=51) and in-service (n=9) teachers who evaluated a selection of 11 apps. The data collected was used to study the factor structure of the tool, its reliability and usability. In this paper we present the resulting questionnaire consisting of 36 items grouped into six sections: “Information about the evaluator”, “Technical and descriptive characteristics”, “Pedagogical characteristics in relation to autism”, “General pedagogical characteristics”, “Characteristics for educational inclusion and accessibility”, and “Professional satisfaction”. The results condense the questionnaire to two factors and indicate that the tool is valid, reliable and useful for assessing the properties of apps and for facilitating the learning process of people with autism.
Online Learning: From the Curriculum for All to the Curriculum for Each Individual
Authors: Viana Joana , Peralta Helena 
Published: January 2021

Abstract
This paper seeks to study curriculum as a form of organization of the learning process from the perspective of the learner, in online learning contexts. Departing from a theoretical and conceptual analysis of curriculum, understood as the conception, organization and structuring of the learning process, we analyzed different adults’ representations of online learning and their general conceptions of curriculum. The empirical data came from the application of a questionnaire, distributed online (study I, 833 participants), and semi-structured interviews (study II, seven participants). The results contribute to the reflection on curriculum in a digital context, and to describing the curriculum organization of the learning process adopted by each individual. We found that space and time, in addition to strategies and actors are the most dynamic curriculum components in these circumstances. The formal contexts in which institutionalised learning and the curricula in force therein, occur are central to the development of the personal learning curriculum. This leads us to question the possibilities and ways of reconfiguring curriculum, of conceiving it differently, in digital learning contexts.
Underdetermination, Assemblage Studies and Educational Technology: Rethinking Causality and Re-Energising Politics
Authors: Perrotta Carlo 
Published: January 2021

Abstract
This article examines underdetermination as a key theoretical assumption in an emerging body of educational research. Underdetermination is described as a broad philosophical position that assumes that social, scientific and technological phenomena cannot be reduced to linear relationships between antecedents and consequences, for instance through the canonical progression from scientific hypotheses to experimentation and then empirical truths. Rather, phenomena are underdetermined by constellations of social and material influences that make the choice of univocal explanations problematic. The principle of underdetermination is implicit in a recent strand of educational research that critiques orthodox interpretations of scientific practices, innovation processes and policy dynamics, recasting them as social, material and political “assemblages”. In the article, I analyse the philosophical and epistemological tenets of underdetermination, in order to clarify its nature as a “first principle” in this emerging body of research. By doing so, the article brings into view a broader theoretical debate that has great bearing on future research efforts. The article critically considers the continued theoretical relevance of underdetermination, whilst acknowledging critical arguments mounted against it, namely ontological relativism and political weakness. Some supplementing theoretical ideas are explored in the conclusion.
Ameliorative Effect of Nutmeg (Myristica fragrans) Supplement against Acetaminophen - Induced Hepato-Renal Toxicity in Wistar Rats
Authors: Abaekwume Chukwunyere Ogechi , Kagbo Hope Delesi 
Published: January 2021

Background: Recently, many drugs have been developed and used for the treatment of hepatic and renal diseases. Nutmeg apart from being utilized as kitchen spices in Nigeria has also been used for healing and medicinal purposes.
Aims: In the present study, nutmeg supplement was evaluated against Acetaminophen (APAP) induced hepato- renal-toxicity.
Study Design: Twenty (20) adult wistar rats weighing185-220 were obtained from animal house of the department of Pharmacology University of Port Harcourt were divided into four groups having 5 rats each (n=5).
Methodology: The animals were divided into four groups of 5 rats each: Group A (normal control) were administered distilled water, group B (negative control) received a single dose of acetaminophen (1000 mg/kg) for two days. Group C received 500 mg/kg body weight of nutmeg supplement one hour before receiving 1000 mg/kg acetaminophen, while group D received acetaminophen (1000 mg/kg) only on day 1 and 2 and the drug extracts on day 3-7. All dosage was dissolved in distilled water orally. The experiment lasted for seven days. Twenty four hours after drugs administrations the animals in each group were anaesthetized. Blood samples were collected and animals sacrificed, liver and kidney tissues removed for various histopathological, biochemistry, antioxidant and haematological examinations using standard procedures. Statistical analysis was done using ANOVA and Tukey poc-hoc Test.
Results: Administration of nutmeg supplement orally effectively restrained APAP-induced alterations in the activities of hepatic (48.60-38.00) and renal markers and Antioxidant enzymes in liver (0.43-0.53). The hepatic and renal architecture of APAP administered rats showed distorted liver and kidney tissues, hepatic vacuolations, destroyed glomerular and renal tubules. Nutmeg+APAP as well as APAP+ Nutmeg administrations were able to ameliorate the effects of APAP administration.
Conclusion: The result indicated that APAP overdosed is hepato-renal- toxic and Nutmeg supplement possessed hepato-prote-curative properties as well as renal-prote-curative properties against APAP-induced damage in rats.