bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Signatures of Glucose Homeostasis: Synergistic Interplay With Long-Term Exposure to Cigarette Smoking in Development of Primary Colorectal Cancer Among African American Women
Authors: Jung Su Yon 
Published: October 2021

INTRODUCTION:
Insulin resistance (IR)/glucose intolerance is a critical biologic mechanism for the development of colorectal cancer (CRC) in postmenopausal women. Whereas IR and excessive adiposity are more prevalent in African American (AA) women than in White women, AA women are underrepresented in genome-wide studies for systemic regulation of IR and the association with CRC risk.

METHODS:
With 780 genome-wide IR single-nucleotide polymorphisms (SNPs) among 4,692 AA women, we tested for a causal inference between genetically elevated IR and CRC risk. Furthermore, by incorporating CRC-associated lifestyle factors, we established a prediction model on the basis of gene–environment interactions to generate risk profiles for CRC with the most influential genetic and lifestyle factors.

RESUTLS:
In the pooled Mendelian randomization analysis, the genetically elevated IR was associated with 9 times increased risk of CRC, but with lack of analytic power. By addressing the variation of individual SNPs in CRC in the prediction model, we detected 4 fasting glucose–specific SNPs in GCK, PCSK1, and MTNR1B and 4 lifestyles, including smoking, aging, prolonged lifetime exposure to endogenous estrogen, and high fat intake, as the most predictive markers of CRC risk. Our joint test for those risk genotypes and lifestyles with smoking revealed the synergistically increased CRC risk, more substantially in women with longer-term exposure to cigarette smoking.

DISCUSSION:
Our findings may improve CRC prediction ability among medically underrepresented AA women and highlight genetically informed preventive interventions (e.g., smoking cessation; CRC screening to longer-term smokers) for those women at high risk with risk genotypes and behavioral patterns.
Tebal Dinding dan Diameter Lumen Arteria Koronaria Tikus Putih Setelah Pemberian Teh Kombucha Kadar 75% Waktu Fermentasi 6, 9 dan 12 Hari
Authors: Isdadiyanto Sri 
Published: October 2021

Tujuan penelitian ini untuk mengetahui pengaruh pemberian teh kombucha kadar 75% sebagai drinking water dengan variasi waktu fermentasi. Penelitian ini menggunakan Tikus putih (Rattus norvegicus) jantan sebanyak 16 ekor umur 2 bulan, dengan perlakuan Teh kombucha yang difermentasi selama 6, 9 dan 12 hari pada suhu 25oC per oral. Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan (selama 28 hari) dan 4 ulangan, yaitu : P0 = kontrol, tanpa tambahan teh kombucha, P1 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 6 hari, P2 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 9 hari, P3 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 12 hari. Variabel yang diukur adalah kadar kolesterol, HDL dan LDL. Data yang diperoleh dianalisis menggunakan ANOVA yang dilanjutkan dengan Uji Duncan dengan taraf kepercayaan 95% dengan menggunakan perangkat lunak SPSS 10,0. Hasil penelitian menunjukkan bahwa pemberian teh kombucha tidak mempengaruhi tebal dinding dan diameter lumen arteria koronaria tikus putih (Rattus norvegicus).
Struktur Histologi Hepar Puyuh Jepang (Coturnix coturnix japonica) yang Diberi Pakan Organik
Authors: Nurmila Ika Oktavia , Saraswati Tyas Rini , Isdadiyanto Sri 
Published: October 2021

Penelitian ini bertujuan mengkaji pengaruh pemberian pakan organik terhadap diameter hepatosit dan struktur histologi hepar puyuh jepang (Coturnix coturnix japonica). Penelitian ini menggunakan 60 ekor puyuh jepang yang terdiri atas 4 perlakuan, masing-masing perlakuan terdiri atas 3 ekor puyuh dan dilakukan 5 kali ulangan. Perlakuan dalam penelitian terdiri atas 4 kelompok yaitu P0 merupakan puyuh yang diberi pakan komersial, P1 merupakan puyuh yang diberi pakan organik standar, P2 merupakan puyuh yang diberi pakan organik dengan kandungan daun singkong, kunyit, dan ikan kembung, dan P3 merupakan puyuh yang diberi pakan organik dengan kandungan daun singkong, kunyit, dan rumput laut. Perlakuan diberikan selama 4 bulan. Penelitian menggunakan Rancangan Acak Lengkap (RAL). Parameter yang diukur dalam penelitian adalah diameter hepatosit, diameter lobulus hepar, bobot hepar, dan bobot badan puyuh jepang serta deskripsi struktur histologi hepar. Data dianalisis dengan Analysis of Varian (ANOVA), bila terdapat perbedaan dilanjutkan dengan Uji Duncan dengan taraf kepercayaan 95%. Hasil analisis data terdapat perbedaan nyata pada diameter hepatosit, diameter lobulus hepar, dan bobot hepar, namun tidak terdapat perbedaan nyata terhadap bobot badan puyuh jepang yang diberi pakan organik. Disimpulkan bahwa pemberian pakan organik mampu mengoptimalkan fungsi hepar puyuh. Kata kunci: pakan organik, puyuh jepang, hepatosit, kunyit
Kadar Apoprotein A dan Apoprotein B Serum Darah Tikus Putih (Rattus norvegicus L.) yang diinduksi Pakan Tinggi Lemak Setelah diberi Ekstrak Etanol Daun Mimba (Azadirachta indica)
Authors: Isdadiyanto Sri , Sitasiwi Agung Janika , Mardiati Siti Muflichatun 
Published: October 2021

Penelitian ini bertujuan untuk menguji pengaruh ekstrak etanol daun mimba (Azadirachta indica) terhadap kadar apoprotein A dan apoprotein B tikus putih (Rattus norvegicus L.) yang diberi pakan tinggi lemak. Penelitian menggunakan Rancangan Acak Lengkap, sebanyak 24 ekor tikus putih jantan dewasa digunakan sebagai hewan uji, dibagi 6 perlakuan dan 4 kali ulangan. Perlakuan meliputi P0 (control), P1 (pakan tinggi lemak), P2 (simvastatin 8 mg), P3; P4; dan P5 (uji dosis ekstrak etanol daun mimba 75; 100; dan 125 mg). Hari terakir perlakuan, hewan dikorbankan dan diambil darahnya untuk analisis kadar apoprotein A dan apoprotein B. Kadar apoprotein A dan apoprotein B serum darah ditentukan dengan metode colorimetric enzymatic menggunakan cobas c reagents kits. Kadar apoprotein A dan apoprotein B serum darah diukur dengan menggunakan Roche/Hitachi cobas c systems automatically calculate. Hasil penelitian menunjukkan bahwa pakan tinggi lemak berpengaruh meningkatkan kadar apoprotein B, ekstrak etanol daun mimba berpengaruh meningkatkan kadar apoprotein A dan menurunkan kadar apoprotein B.
Pengaruh Air Rendaman Batang Balimo (Zanthoxylum nitidum) terhadap Histologis Ginjal Tikus Putih (Rattus norvegicus) Setelah Diberi Ciu.
Authors: Purba Swidy Damayanti , Tana Silvana , Saraswati Tyas Rini 
Published: October 2021

Batang Balimo mengandung senyawa alkaloid yang mempunyai efek anti inflamasi untuk mengurangi pembengkakan pada ginjal dan mengandung antioksidan yang dapat menghambat reaksi oksidasi, dengan mengikat radikal bebas dan molekul yang sangat reaktif yang dihasilkan dari metabolisme alkohol. Atas dasar potensi tersebut dilakukan penelitian yang bertujuan untuk mendeskripsikan, menguji dan menganalisis pengaruh air rendaman batang Balimo terhadap kerusakan glomerulus, tubulus kontortus proksimal, tubulus kontortus distal ginjal, bobot ginjal, rasio bobot ginjal terhadap bobot tubuh tikus putih menjadi normal yang sebelumnya telah diberi konsumsi ciu. Penelitian menggunakan rancangan acak lengkap menggunakan 20 ekor tikus yang dibagi menjadi 4 kelompok, yaitu P0 (kelompok kontrol negatif), P1 (kelompok kontrol positif diberi ciu 2 minggu), P2(kelompok kontrol positif diberi ciu 2 minggu dan air rendaman batang Balimo 2 minggu) dan P3 (kelompok kontrol positif diberi ciu 4 minggu dan air rendaman batang Balimo 2 minggu). Hasil analisis dengan uji Anova menunjukan tidak terdapat pengaruh bermakna (p>0,05) dari pemberian air rendaman batang balimo terhadap bobot ginjal, diameter glomerulus, diameter lumen tubulus kontortus proksimal, lumen tubulus kontortus distal dan rasio bobot ginjal terhadap bobot badan tikus yang diberi ciu. Berdasarkan deskripsi histologis ginjal dapat disimpulkan bahwa batang balimo memperbaiki ginjal yang mengalami hipertropi karena konsumsi ciu.
Massive open online courses for professional certificate programs? Perspectives on professional learners’ longitudinal participation patterns
Authors: Tang Hengtao , Xing Wanli 
Published: October 2021

Massive open online courses (MOOCs) have been integrated into higher education systems as an option for delivering online professional degree and certificate programs; however, concerns about whether employed professionals actively participate in MOOCs remain unresolved. Some researchers have described learners’ employment as the major cause of attrition from MOOCs, but research has not addressed how employed learners interact with MOOCs over time. Understanding employed professionals’ trajectory of participation patterns across course time is thus essential to improving the effectiveness of MOOCs. This study investigated the log data of learner participation to explore how attrition occurs in a professional MOOC, focusing on whether students’ employment status was associated with learner participation. The results revealed learners’ longitudinal participation patterns and confirmed the impact of sustained engagement on course performance. The study also found that employed learners were more likely than their peers without jobs to become cramming learners with initially infrequent engagement in a course but investing intensive time at the end for certificates. We discuss practical implications for designing and facilitating large-scale professional degree and certificate programs in higher education institutions.
Implications for practice or policy:

Educators can apply MOOCs with a lower weekly workload and a slower pace to support employees’ professional development.
Educators should develop professional learners’ interests in the course topic to avoid only cramming for the course certificates.
Educators may consider longitudinal patterns of learner participation when assessing learner performance.
Remodelling the role of facilitating conditions for Google Classroom acceptance: A revision of UTAUT2
Authors: Brandford Bervell Brandford , Kumar Jeya Amantha , Arkorful Valentina , Agyapong Emmanuel Manu , Osman Sharifah 
Published: October 2021

Online learning environments have become a contemporary component of global tertiary education due to their affordances. These environments are hinged on internet-based learning management systems and one such tool is Google Classroom. However, empirical studies have indicated that gaps exist in determining how Google Classroom influences students’ behavioural intention to use it for online learning. Accordingly, this study defines a model based on the unified theory of acceptance and technology 2 (UTAUT2) to examine the relationship between facilitating conditions and other variables towards intention formation for Google Classroom usage. Based on a mixed method using the explanatory sequential design, survey data from 163 students were initially analysed using partial least squares structural equation modelling followed by a qualitative approach based on open-ended questions for thematic analysis. Results from the partial least squares structural equation modelling approach validated the hypothesised model confirming the significant predictive relationship of facilitating conditions with effort expectancy, hedonic motivation, habit and social influence but had an insignificant relationship with behavioural intention. Furthermore, hedonic motivation and habit were the main predictors of behavioural intention by masking the role of facilitating conditions. Subsequently, the qualitative outcome indicated that habit and perceived control of using Google applications influence hedonic motivation. Finally, recommendations were made to universities towards policy formation and practice of virtual learning using Google Classroom.
Implications for practice or policy:

Higher education institutions should create an environment for students to be motivated and enjoy Google Classroom use.
Universities should provide Internet, technical and pedagogical support for students’ Google Classroom use.
Universities should explain to students the affordances of using Google Classroom.
Universities should encourage students to acquire access gadgets (smartphones or tablets) for Google Classroom use.
Human Skeletons, Grave Goods and Textual Sources: A Multidisciplinary Approach to Southwestern Switzerland’s Late Iron Age Communities through the Study of their Funerary Rites
Authors: Hofstetter Tobias , Desideri Jocelyne , Mariéthoz François , Besse Marie 
Published: October 2021

Abstract
This paper’s primary focus is the investigation of Late Iron Age funeral practices. This is carried out by means of a multidisciplinary study of two necropolises, Randogne – Bluche and Sion – Parking des Remparts, which are located in southwestern Switzerland. The overall purpose of this paper is to enhance the socio-cultural understanding of this period through an integrated approach that combines the fields of bioanthropology, archaeology and ancient cultural history. Consequently, sex, age, pathologies and biological proximity first were assessed for the individuals found in the two studied necropolises. Next, data from these necropolises was contrasted with the archaeological and cultural environment from the surrounding regions. Finally, a combined perspective was developed in order to consider and combine the data collected through these different approaches. The obtained results appear to point to a regional particularism present in southwestern Switzerland’s funerary practices during the Late Iron Age. However, cultural influences from both northern and southern neighbouring regions can be identified in southwestern Switzerland’s funerary rites and material productions, which sheds light on the innerworkings of the Celtic communities populating this region.
A Review of Morphological and Chemical Properties of Porous Asphalt
Authors: Jasni N.E. , Masri Khairil Azman , Jaya R.P. 
Published: October 2021

Porous asphalt mixture is also known as gap graded mixture with less amount of fine aggregate has led the mixture contains high air voids, tends to make the mixture less durable and high porousity. Hence, past researchers has investigate on how to increase the strength of porous asphalt mixture by the addition of additive such as fiber and nanomaterials. The chemical and physical properties of porous asphalt mixture was highlighted in this paper to compare its structure, the bonding between the materials and its chemical composition that exist. This paper reviews on how additive affect the asphalt mixture in terms of Scanning Electron Microscopy (SEM), X-Ray Diffractions (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). These tests are selected to improve the asphalt mixture according to the morphological and chemical properties of porous asphalt. This study is expected to identify the morphological and chemical composition of the materials in asphalt mixture.
Infantile hypercalcaemia type 1: a vitamin D-mediated, under-recognised cause of hypercalcaemia
Authors: Nizar Ryizan , Cantley Nathan W P , Tang Jonathan C Y 
Published: October 2021

Summary
A 33-year-old gentleman of Egyptian heritage presented with a 21 years history of unexplained and recurrent hypercalcaemia, nephrolithiasis, nephrocalcinosis, and myocarditis. A similar history was also found in two first-degree relatives. Further investigation into the vitamin D metabolism pathway identified the biochemical hallmarks of infantile hypercalcaemia type 1 (IIH). A homozygous, likely pathogenic, variant in CYP24A1 was found on molecular genetic analysis confirming the diagnosis. Management now focuses on removing excess vitamin D from the metabolic pathway as well as reducing calcium intake to achieve serum-adjusted calcium to the middle of the reference range. If undiagnosed, IIH can cause serious renal complications and metabolic bone disease.

Learning points

Infantile hypercalcaemia type 1 (IIH) is an autosomal recessive disorder characterised by homozygous mutations in the CYP24A1 gene that encodes the 24-hydroxylase enzyme used to convert active vitamin D metabolites such as 1,25-(OH)2-vitamin D into their inactive form.

IIH should be questioned in individuals presenting with a history of unexplained hypercalcaemia, especially if presenting from childhood and/or where there is an accompanying family history of the same in first and/or second degree relatives, causing complications such as nephrocalcinosis, pericarditis, and calcium-based nephrolithiasis.

Associated biochemistry of IIH is persistent mild to moderate hypercalcaemia, normal or raised 25-(OH)-vitamin D and elevated 1,25-(OH)2-vitamin D. An elevated ratio of 25-(OH)-vitamin D to 24,25-(OH)2-vitamin D can be a useful marker of defects in the 24-hydroxylase enzyme, whose measurement can be facilitated through the supra-regional assay service.

Management should focus on limiting the amount of vitamin D introduced into the body either via sunlight exposure or supplementation in addition to calcium dietary restriction to try and maintain appropriate calcium homeostasis
Graves’ disease associated with HIV disease and late immune reconstitution inflammatory syndrome following the initiation of antiretroviral therapy
Authors: Ludgate S , Connolly S P , Fennell D , Muhamad M F , Welaratne I , Cotter A , McQuaid S E 
Published: October 2021

Summary
Both human immunodeficiency virus (HIV) and antiretroviral therapy (ART) are associated with endocrine dysfunction (1). The term 'immune reconstitution inflammatory syndrome' (IRIS) describes an array of inflammatory conditions that occur during the return of cell-mediated immunity following ART. Graves’ disease (GD) occurs rarely as an IRIS following ART. In this study, we describe the case of a 40-year-old Brazilian female who was diagnosed with HIV following admission with cryptococcal meningitis and salmonellosis. At this time, she was also diagnosed with adrenal insufficiency. Her CD4 count at diagnosis was 17 cells/µL which rose to 256 cells/µL over the first 3 months of ART. Her HIV viral load, however, consistently remained detectable. When viral suppression was finally achieved 21 months post diagnosis, an incremental CD4 count of 407 cells/µL over the following 6 months ensued. Subsequently, she was diagnosed with a late IRIS to cryptococcus 32 months following initial ART treatment, which manifested as non-resolving lymphadenitis and resolved with high-dose steroids. Following the initiation of ART for 45 months, she developed symptomatic Graves’ hyperthyroidism. At this time, her CD4 count had risen to 941 cells/µL. She has been rendered euthyroid on carbimazole. This case serves to remind us that GD can occur as an IRIS post ART and typically has a delayed presentation.

Learning points

Endocrinologists should be aware of the endocrine manifestations of HIV disease, in particular, thyroid pathology.

Endocrinologists should be aware that IRIS can occur following the initiation of ART.

Thyroid dysfunction can occur post ART of which Graves' disease (GD) is the most common thyroid manifestation.

GD as a manifestation of ART-induced IRIS can have a delayed presentation.

Infectious disease physicians should be aware of endocrine manifestations associated with HIV and ART.
NON-VERBAL MEANING OF KERAWANG GAYO BAJU REJE: MULTIMODAL ANALYSIS
Authors: Kemas Wulandari Putri , Sinar T Silvana , Zein T Thyrhaya 
Published: October 2021

This paper discusses the multimodal analysis of non-verbal meanings in the Kerawang Gayo Reje shirt. It is an ornamental motive made by embroidering cloth. Gayo filigree is the identity of the Gayo. Reje clothes are unique clothes for Reje (king/highest leader) in the village of the Gayonese, and they use several Gayo motives, such as Mata Ni Lao (Matahari), a mandatory motive for a Reje. Each motive contains the meaning of the life of the Gayo tribe. Nowadays, use mandatory clothes on Reje is rarely used. This study aimed to determine the non-verbal meaning of the Kerawang Gayo Reje motives through multimodal analysis. The ethnography method was applied in this study. The data were the Kerawang Gayo Reje shirt's visual art content, the interview result, and observation. The informants were craftsman/tailor; and the Majelis Adat Gayo leaders (Gayo traditional centre) in Central Aceh. The data were analyzed by explaining the meaning lies in the means of communication and each meaning centrally, and dominantly of Kerawang Gayo Reje shirt The result of the study showed that there are four types of motives on Reje's clothes, Mata Ni Lao, Tali Puter Tige, Tekukur, and Tapak Sleman. On the Reje shirt, there is only one colour used, which is yellow. The meaning is justice and prosperity for the Gayo tribe community. It is hoped that a Reje will be fair to the people and provide prosperity for the Gayo tribe community.
STUDENTS’ LEARNING CREATIVITY PROFILE REVIEWED FROM SCHOOL ACCREDITATION STATUS
Authors: Maryani Ineu 
Published: October 2021

This article aims to describe the students' learning creativity profile reviewed from school's accreditation status. The method in this study was a survey method by distributing a questionnaire of students’ learning creativity through google form. Participants in the study were grade VIII students in public schools with National Standard School accredited status, schools with A accredited State Junior High School (JHS), and B accredited State Junior High School (JHS). Based on the results of data processing, there was a significant average difference in learning creativity on indicators the ability to deal with learning problems between public schools with National Standard School accredited status and schools with A accredited State JHS. The average ability to deal with learning problems is also significantly different between schools with A accredited State JHS, and B accredited State JHS. A significant difference in average is also shown in the indicators of interest in learning creations and indicators of the ability to develop in learning between public schools with National Standard School accredited status and schools with A accredited State JHS. The results of this study can be used as empirical data for research on guidance and counseling programs to develop students' creativity in schools.Keywords: Profile, learning creativity, student
Contents and Foreword of the MIMBARDIK Journal, Issue of March 2017
Authors: MIMBARDIK Editor Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan(Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September. Bandung, Indonesia: March 30, 2017. Prof. Haji Furqon, Ph.D.Honorable Patron of MIMBAR PENDIDIKAN Journal; and Rector of UPI in Bandung, West Java, Indonesia.