bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dural Sinus Thrombosis after Resection of Vestibular Schwannoma using Suboccipital Retrosigmoid Approach - Thrombosis Classification and Management Proposal.
Authors: Krystkiewicz Kamil , Wrona Dawid , Tosik Marcin , Birski Marcin , Szylberg Łukasz , Morawska Anna , Furtak Jacek , Wałęsa Cezary , Stopa Konrad , Harat Marek 
Published: October 2021

Abstract
ObjectiveDural sinus thrombosis is one of the complications after posterior fossa surgery. However, that topic is not described well with regard to vestibular schwannoma surgery using the unique suboccipital retrosigmoid approach.MethodsWe analyzed retrospectively medical records and radiological investigations of 116 patients. The including criteria were: histopathologically confirmed vestibular schwannoma operated on using the retrosigmoid approach, preoperative and postoperative contrast enhanced MRI, at least 1-year follow-up. ResultsThe patient group included 36% males, 64% females. The average age was 47.3±13.9 years. 60% of tumors were classified as T4b according to the Hannover scale and their mean volume was 13.73±10.28 cm3. There were no signs of thrombosis preoperatively. In 26 (22%) cases, postoperative changes in the dural sinuses were found. In 7 (27%) cases there was an external compression by the hemostatic agent, in 19 (73%) cases a thrombus was visualized in the sinus lumen. The size of the sinus, age, tumor size were not risk factors for thrombosis, whereas an intraoperative sinus injury was a statistically significant risk factor (p=0.0012). All of the patients diagnosed with thrombosis were in good clinical condition in distant follow-up (mRankin=0). Complete recanalization was observed in 58% of cases after 1-year follow-up.ConclusionsPostoperative changes in the dural venous sinuses are a frequent finding after vestibular schwannoma surgery using the suboccipital retrosigmoid approach. Intraoperative dural injury is a risk factor for thrombosis. Thrombosis in that group of patients is usually asymptomatic and does not influence the prognosis.
A Quantum System Control Method Based on Enhanced Reinforcement Learning
Authors: Liu Wenjie , Wang Bosi , Fan Jihao , Ge Yebo , Zidan Mohammed 
Published: October 2021

Abstract
The design of quantum system control is a key task to a powerful quantum information technology. In practical, traditional quantum system control methods often face different constraints, and are easy to cause both leakage and stochastic control errors under the condition of limited resources. Reinforcement learning has been proved as an efficient way to complete the quantum system control task. So a quantum system control method based on enhanced reinforcement learning (QSC-ERL) is proposed. A satisfactory control strategy is obtained through enhanced reinforcement learning so that the quantum system can be evolved accurately from the initial state to the target state. According to the number of candidate unitary operations, the three-switch control is used for simulation experiments. Compared with other methods, the QSC-ERL can achieve high fidelity learning control of quantum systems and improve the efficiency of quantum system control.
Sex Specific Effects of PET-MPs On Drosophila Lifespan
Authors: Shen Jie , Liang Boying , Zhang Dake , Ding Sitong , Li Yan , Tang Hao 
Published: October 2021

Abstract
In recent years, as an emerging pollutant, microplastic pollution is gradually becoming a research hotspot. Microplastics are ubiquitous in the entire ecological environment. Organisms can be exposed to microplastics via inhalation or ingestion. In view of the widespread of microplastics pollution, the impact of microplastics on biology should be further investigation. In previous experiments, we have conducted research on the physiology of Drosophila exposed to PET Microplastics (PET-MPs). However, under long-term exposure, will PET-MPs affect the lifespan of Drosophila? Our experimental results indicate that for ANOVA analysis, there are significant differences between males and females (F (1, 895) =68.19, p<0.001), between PET-MPs concentration (F (3, 895) = 8.11, p<0.001). There are also significant interactions between sex and Microplastic concentration (F (3, 895) = 4.00, p<0.01). For Cox and log rank test, 1g/L of PET-MPs prolongs the lifespan of male flies. The reason of this phenomenon may be the hormesis effect.
Computational Binding Analysis of Ethyl 3,3,5,5-tetracyano-2-hydroxy-2-methyl-4,6-diphenylcyclohexane-1-carboxylate in Calf Thymus DNA
Authors: Kurbanova Malahat , Kurbanova Malahat Musrat , Saravanan Kandasamy , Ahmad Sajjad , Sadigova Arzu , Askerov Rizvan , Magerramov Abel , Bakri Youness El 
Published: October 2021

Abstract
In the present paper, several computational binding analysis were performed on Ethyl 3,3,5,5-tetracyano-2-hydroxy-2-methyl-4,6-diphenylcyclohexane-1-carboxylate which was newly synthesized by three-component condensation of benzaldehyde with ethyl acetoacetate and malononitrile in the presence of trichloroacetic acid and the structure was finally proved by X-ray analysis. The visualization of molecular interaction was carried out through Hirshfeld surface analysis and ESP. The atomic charges, HOMO, LUMO and electrostatic potential were also studied to explore the insight of the molecule deeper and then, natural bonding orbitals (NBO) and nonlinear optical properties (NLO) were calculated to reveal the interactions that happen to be between the filled and vacant orbitals. Afterwards, Molecular docking studies predicted the compound binding mode fits in the minor groove of DNA and remained interacts via stable bonding as validated by molecular dynamics simulations. The binding energy estimation also affirmed domination van der Waals and electrostatic energies. Lastly, the compound was found as good drug like molecule and had good pharmacokinetic profile with exception of toxic moieties.
Host Tau Genotype Specifically Regulates and Designs Tau Seeding and Spreading Following Intracerebral Injection of Identical Tau AD Inoculum
Authors: Andrés-Benito Pol , Carmona Margarita , Jordán Mónica , Rio José Antonio del , Ferrer Isidro 
Published: October 2021

Abstract
Background: Several studies have demonstrated the capacity for seeding and spreading of tau-enriched fractions of brain homogenates from AD and other human and mouse tauopathies following intracerebral inoculation into transgenic mice bearing human tau or mutant human tau and into WT mice. However, little attention has been paid about the importance of host tau in tau seeding. Methods: The brains of four adult murine genotypes expressing different forms of tau—WT (murine 4Rtau), P301S (human 4Rtau expressing the P301S mutation), hTau (homozygous transgenic mice knock-out for murine tau protein and heterozygous expressing human forms of 3Rtau and 4Rtau proteins), and mtWt (homozygous transgenic mice knock-out for murine tau protein)—were analyzed following unilateral hippocampal inoculation of sarkosyl-insoluble tau fractions from the same AD case. Results: No tau deposits were identified in inoculated mtWT mice. Involvement of CA1 neurons was higher and that of oligodendrocytes lower in inoculated hTau when compared with inoculated WT and P301S mice. tau-P Ser422, PHF1, and MAP2-P immunoreactivity was moderate or weak in WT and P301S, but strong in inoculated hTau mice. p38-P and SAPK/JNK-P were observed in recruited phospho-tau deposits in inoculated WT, P301S, and hTau mice. However, CK1-δ, GSK-3β-P Ser9, AKT-P Ser473, PKAα/β-P Tyr197, and CLK1 were identified in neurons with tau deposits only in inoculated hTau. Finally, 3Rtau deposits predominated in inoculated WT and P301S, and 4Rtau deposits in hTau transgenic mice. Conclusions: Our results reveal that a) host tau is mandatory for tau seeding and spreading following tau inoculation; b) tau seeding and spreading is characterized by major genotype-dependent biochemical changes linked to post-translational tau modifications including tau phosphorylation and tau nitration at different sites, c) it is accompanied by genotype-dependent activation of various kinases thus pointing to a complex molecular response in the receptive host cells; d) tau seeding and spreading is accompanied by modifications in tau splicing with variable expression of new 3Rtau and 4Rtau isoforms; e) selective regional and cellular vulnerabilities, and different molecular compositions of the deposits are dependent on the host tau genotypes injected with identical AD tau inoculum.
Resveratrol Alleviates Pyraclostrobin Induced Lipid Peroxidation, Oxidative Stress, and DNA Damage in Rats
Authors: NAVRUZ FAHRIYE ZEMHERI , INCE Sinan , ARSLAN-ACAROZ Damla , ACAROZ Ulaş , DEMIREL Hasan Hüseyin , DEMIRKAPI Ezgi Nur 
Published: October 2021

Abstract
Pyraclostrobin (Pyra) is a fungicide in the strobilurin class and has proven to be very toxic to aquatic species. Resveratrol (Res) is a phytoalexin that exhibits multiple bioactivities as antioxidative, anti-inflammatory, cardiovascular protective, and anti-aging in animals and is found in plant species such as mulberry, peanut, and grape. This study aimed to determine the protective effect of Res against Pyra-induced oxidative stress in rats. For this purpose, a total of 48 male rats divided into 6 groups − 8 in each group - were exposed to 30 mg/kg Pyra by oral gavage once a day for 4 weeks and to 3 different concentrations of Res (5, 10 and 20 mg/kg) together with Pyra. It was observed that, in groups administered with Pyra, malondialdehyde (MDA) levels increased whereas glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels decreased. It was observed that, in the group administered with Pyra, expression levels of CYP2E1 gene, which is associated with increased cancer risk, pro-apoptotic BAX gene, apoptotic caspase-3, caspase-8 and caspase-9 genes, NFκB gene, which is a pro-inflammatory transcription factor, and p53 gene, which plays a regulatory role in the cell, increased whereas expression level of anti-apoptotic bcl-2 gene decreased. It was determined that Res administrations improved Pyra-induced oxidative damage, histopathological changes and expression levels of various genes. According to the ssDNA analysis obtained from the DNA isolated from the blood; when DNA damage and histopathological damage in tissues were examined, it was observed that the highest damage was in the group administered with Pyra and the damage decreased depending on the increase in dose of Res. Consequently, it was observed that Res, known for its antioxidant protective properties, exhibited a protective effect against oxidative stress caused by Pyra.
Outcomes and Hemodynamic Performances of Transcatheter Aortic Valve Replacement With Two Generations of Self-expanding Transcatheter Aortic Valves
Authors: Kuo Chia-Cheng , Chang Hsiao-Huang , Leu Hsin-Bang , Chen I-Ming , Chen Po-Lin , Lin Su-Man , Chen Ying-Hwa 
Published: October 2021

Abstract
The aim of this study was to investigate the hemodynamic and clinical performance of the Evolut R compared with its direct predecessor, CoreValve, in Taiwanese population. This study included all consecutive patients who underwent TAVR with either the CoreValve or Evolut R between March 2013 to December 2020. Thirty-day Valve Academic Research Consortium-2 (VARC-2)-defined outcomes and hemodynamic performances were investigated. There were no significant differences in baseline demographic characteristics between patients receiving CoreValve (n= 117) or Evolut R (n=117). Aortic valve-in-valve procedures for failed surgical bioprosthesis and procedures under conscious sedation were performed significantly more often with Evolut R. Pre-dilatation was performed significantly more often and contrast media volume was significantly higher with CoreValve. Stroke (0% vs 4.3%, p = 0.024) and the need for emergent conversion to open surgery (0% vs 5.1%, P = 0.012) were significantly lower in Evolut R than CoreValve recipients. Evolut R significantly reduce 30-day composite safety endpoint (4.3% vs 15.4%, p = 0.004). In conclusion, advancements in transcatheter valve technologies have resulted in improved outcomes for patients undergoing TAVR with self-expanding valves. With new-generation Evolut R, device success was high and significantly reduced 30-day composite safety endpoint after TAVR compared with CoreValve.
Two Cases of Anomalous Origin of Left Coronary Artery From The Pulmonary Artery
Authors: Juan Zhao , Chunbo Zou 
Published: October 2021

Abstract
Coronary artery originating from pulmonary artery is a rare congenital vascular malformation, which generally presents corresponding clinical symptoms with the growth of patients' age. Coronary CTA and angiography are important methods for diagnosis of this disease, and provide evidence for treatment strategies of patients.
Prognostic Value of Tumor Deposits in Colorectal Cancer: A Population-based Retrospective Cohort Study
Authors: Wu Wenhao , Zeng Shun , Zhang Xianbin , Liu Peng , Qiu Tong , Li Shulin , Gong Peng 
Published: October 2021

Abstract
BackgroundThe role of tumor deposits (TDs) in TNM staging of colorectal cancer is controversial, especially the relationship with distant metastasis.PurposeThe aim of this study was to determine the effect of TDs on the survival of colorectal cancer and the occurrence of distant metastasis, and to determine whether TDs (+) patients behaved similarly to stage IV patients.MethodsRetrospective analysis of CRC patients from two large independent cohorts from the Surveillance Epidemiology and End Results (SEER) database (n=58775) and the First Affiliated Hospital of Dalian Medical University (n=742).ResultsUnivariate logistic analyses revealed that TDs as an independent predictor of liver metastasis [p<0.001; odds ratio (OR): 5.738; 95% confidence interval (CI): 3.560-9.248] in the The First Affiliated Hospital of Dalian Medical University’s patients. Meanwhile, TDs was also an independent predictor of isolated organ metastasis [p<0.001; odds ratio (OR): 3.028; 95% confidence interval (CI): 2.414 - 3.79; multiple organ metastases [p<0.001; odds ratio (OR): 4.778; 95% confidence interval (CI): 4.109 - 5.556]; isolated liver metastasis [p<0.001; odds ratio (OR): 4.395; 95% confidence interval (CI): 4.099 - 4.713] and isolated lung metastasis [p<0.001; odds ratio (OR): 5.738; 95% confidence interval (CI): 3.560-9.248] in the SEER database. Multivariate analyses suggested TDs were an independent poor prognostic factor for distant metastasis (p<0.001).ConclusionsOur results have shown that compared with patients with negative TDs, CRC patients with positive TDs are more likely to develop distant metastasis. Patients who categorized T4aN2bM0 TDs (+) and T4bN2M0 TDs (+) have similar prognosis as those with stage IV, and these patients should be classified as stage IV.
Could miR34a be as a Potential Biomarker for Doxorubicin Induced Cardiotoxicity?
Authors: Yildirim Eda Caliskan , Gedik Emre , Gunaydin Gurcan , Coteli Cem , Ozer Necla , Uner Aysegül , Yüce Deniz , Turker Alev 
Published: October 2021

Abstract
No biomarker is currently available for early detection of anthracycline-induced cardiotoxicity. The purpose of this study was to assess whether the plasma levels of microRNA34a (miR34a) could predict cardiotoxicity in breast cancer patients who received anthracycline-based chemotherapy.Forty-four breast cancer patients who received anthracycline-based chemotherapy for the first time were included in the study. Before and after taking chemotherapy, patients were examined for cardiac troponin-I, miR34a, and precursor miR34a levels, and echocardiographic strain analyses were performed. There was a statistically significant increase in troponin-I, miR34a, and pre-miR34a levels after treatment with anthracyclines. The mean increase in miR34a and pre-miR34a was 2.5 and 2.3 fold, respectively. Echocardiographic analysis of patients showed a significant decrease in global longitudinal strain (GLS) measurements compared to the baseline after anthracycline treatment. An increase in the levels of miR34a/pre-miR34a was detected in patients who were estimated to have cardiac damage according to GLS change, but this increase was not statistically significant. After doxorubicin treatment, an increase in miR34a level in plasma was demonstrated without correlation with cTn-I and GLS. A higher miR34a/pre-miR34a ratio was detected in patients with myocardial deformation than in those without myocardial deformation, but it was not statistically significant.
Chemometrics, Health Risk Assessment and Probable Sources of Total Petroleum Hydrocarbons in Atmospheric Rainwater in Rivers State, Nigeria.
Authors: Omokpariola Daniel , Nduka John , Kelle Henrietta , Mgbemena MaryAnn , Iduseri Emily 
Published: October 2021

Abstract
Total petroleum hydrocarbons (TPHs)-(aliphatic and aromatic) were analysed for in atmospheric rainwater between April- June; July – August; September–October depicting early, mid, late rain of 2019. Sampling at Rumuodomaya/ Rumuodome and Ogale in Rivers State using basins fastened to a table 2 M above ground and 120 M from high features, Rainwater was analysed after treatment using Agilent GC-FID. Results show cumulative TPHs at R/R were 56.6551mg/L, 39.5201mg/L and 7.2283mg/L, Ogale: 9.1217mg/L, 59.4923mg/L and 21.9825mg/L. Aliphatic hydrocarbons: C5 – C8 were < 1, low contamination, other carbon aggregates (C9 – C16, C17– C35, and C36 – C40) indicate high contamination. Chemometric assessment showed high contamination. TPHs aggregates at Rumuodomaya/ Rumuodome were- C8 – C11 (1.034 and 1.005) early rain, C18 – C25 and C26 – C33 has Carbon preference index of 1.287 and 1.630 (mid-rain), C26 – C33 has CPI of 1.288 (late-rain), Ogale area, C26–C33 has CPI of 1.732 (early-rain), mid-rain C8 – C11 (2.768) and C12–C17 (5.368). Pristane/phytane ratio indicated biogenic and pyrogenic sources. Average carbon length of TPHs for odd n-alkanes were C9 – C11 (9.446) and C35 – C39 (38.980), C9 – C11(10.238), C35 – C39 (36.510); C9 – C11 (10.240) and C35 – C39 (36.934). Average daily intake depicted possible health issues for children and adults as hazard index > 1 for aromatics.
Consistent Trait-Temperature Interactions Drive Butterfly Phenology in Both Incidental and Survey Data
Authors: Larsen Elise A. , Belitz Michael W. , Guralnick Robert P. , Ries Leslie 
Published: October 2021

Abstract
Data availability limits phenological research at broad temporal and spatial extents. Butterflies are among the few taxa with broad-scale occurrence data, from both incidental reports and formal surveys. Incidental reports have observation biases that are challenging to address, but structured surveys are often limited seasonally and may not span full flight phenologies. Thus, which data source is more useful for phenological analyses is unclear. We use parallel analyses of incidental and survey data to determine how traits and climate drive phenological patterns for common butterflies. One workflow aggregated “Pollard” surveys, where sites are visited multiple times per year; the other aggregated incidental data from online portals: iNaturalist and eButterfly. For 40 routinely observed resident species, we estimated early (10%) and mid (50%) flight period metrics, and compared the spatiotemporal patterns and drivers of phenology across species and between datasets. Results were similar between datasets. Inter-annual variability was best explained by temperature, and seasonal emergence was earlier for resident species that overwinter at more advanced stages. Other traits had mixed or no impacts. The consistency in results suggests that data integration can improve phenological research, and leveraging traits may predict phenology in poorly studied species.
Does Immunohistochemically CD5 Positivity Matter In Diffuse Large B-Cell Lymphoma Patients? Turkish Multicenter Study
Authors: Demirci Ufuk , Kırkızlar Hakkı Onur , Ümit Elif Gülsüm , Gürsoy Vildan , Pınar İbrahim Ethem , Özkalemkaş Fahir , Güven Zeynep Tuğba , Kaynar Leylagür , Karadağ Fatma Keklik , Saydam Güray , Ekinci Ömer , Merter Mustafa , Aras Merih Reis , Albayrak Mustafa , Gülsaran Sedanur Karaman , Baş Volkan , Aydın Berrin Balık , Beköz Hüseyin Saffet , Can Ferda , D İmdat , Mehtap Özgür , Öztürk Erman , Şimşek Bengü Çöbanoğlu , Yıldırım Murat , Aylı Meltem , Ataş Ünal , Salim Ozan , Ayer Mesut , Ateşoğlu Elif Birtaş , Akay Olga Meltem , Yüksel Meltem Kurt , Paydaş Semra , Korkmaz Selçuk , Puyan Fulya Öz , Demir Ahmet Muzaffer 
Published: October 2021

Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common sub-type of Non-Hodgkin lymphomas (NHL) and it is a very heterogeneous group of diseases. CD5 positivity is profound in a substantial patient population in DLBCL. In this population, female patient distribution is higher, LDH elevation, extra nodal involvement, bone marrow involvement, ECOG (Eastern Cooperative Oncology Group) performance score elevation and high international prognostic score (IPI> 2) are more frequent for CD5 - DLBCL. Also, it was observed that prognosis of CD5 + DLBCL was worse than CD5 - DLBCL. We aimed to determine the frequency of CD5 positivity in DLBCL in Turkey with this multicenter study.Methods: The study, in order to get the overall parts from Turkey, including from each geographical area, 16 center and 9 cities were included. Each center retrospectively scanned the diagnostic pathology reports of DLBCL patients between January 2015-2021.Results: Two thousand four hundred sixty-nine DLBCL patients were screened retrospectively. CD5 positivity was detected in 169 patients (6.84%). The average age was 59 and 55.7% of the patients were male. Overall survival was 29.8 months. When evaluated with historical data in this group of patients, poor prognostic factors were found to be more common than CD5 - DLBCL patients.Conclusion: Due to its prognostic effect, immunohistochemically, the presence of CD5 in pathological samples of all DLBCL patients should be checked. The effect on prognosis in this patient group should not be forgotten while treatment and follow-up.