bluuebunny/crossref_metadata_2025_split huggingface dataset:
International guidelines for self-report and proxy completion of paediatric health-related quality of life measures: a protocol for a systematic review
Authors: Mpundu-Kaambwa Christine , Chen Gang , Dalziel Kim , Devlin Nancy , Ratcliffe Julie 
Published: December 2021

IntroductionMeasures of health-related quality of life (HRQoL), accompanied by the values (or utilities) required to estimate quality-adjusted life-years, are crucial for determining health benefits within economic evaluation and health technology assessment. Several generic and condition-specific measures or instruments of HRQoL, accompanied by values, currently exist for application with child populations. However, there is a lack of a structured summary of guidelines and recommendations for applying these measures in practice. This protocol describes a systematic review of guidelines and recommendations for child and proxy completion of child-specific measures of HRQoL. The aims of the review are to (1) identify and summarise published guidelines and recommendations for existing child-specific measures of HRQoL, (2) determine whether the identified guidelines and recommendations differ by instrument and child characteristics, (3) identify current gaps in these guidelines and recommendations and (4) identify best practices for child self and proxy assessment in paediatric HRQoL measurement for economic evaluation and health technology assessment.Methods and analysisThe review will identify, collate and synthesise published guidelines and recommendations for existing child-specific utility measures of HRQoL. Electronic databases to be searched include the Cochrane Library, Medline, Scopus, Web of Science, EconLit, PsycINFO, CINAHL, Embase and Informit. The search will be extended to websites of (1) international organisations for health technology assessment, (2) regulation, health economics and HRQoL outcomes research and (3) instrument developers. Three reviewers will independently screen titles and abstracts against the inclusion criteria. A narrative synthesis will describe the key features of the guidelines identified.Ethics and disseminationEthical approval is not required as the proposed systematic review will not use primary data. A paper of the systematic review will be submitted to a peer-reviewed journal for publication.PROSPERO registration numberCRD42020207160.
Determining the effectiveness of cognitive behavioural therapy in improving quality of life in patients undergoing endometriosis surgery: a study protocol for a randomised controlled trial
Authors: Boersen Zoë , Oosterman Joukje , Hameleers Esther Gerdien , Delcliseur Heidi Sabine Mathilde Jeanne , Lutters Cobie , IJssel de Schepper Alicia , Braat Didi , Verhaak Christianne M , Nap Annemiek 
Published: December 2021

IntroductionEndometriosis can cause chronic pain and subfertility thereby negatively affecting quality of life (QoL). Surgical removal of endometriosis lesions leads to improved health-related QoL, although not to the level of QoL of healthy controls. Pain intensity and cognitions regarding pain can play a crucial role in this health-related QoL following surgical treatment. Cognitive behavioural therapy (CBT) is a psychological treatment. In patients with chronic pain caused by a variety of medical conditions, CBT is effective in improving QoL. We designed a research protocol to investigate the effect of CBT on QoL in patients with endometriosis-associated chronic pain who are undergoing surgery.Methods and analysisThis is a study protocol for a randomised controlled trial in which 100 patients, undergoing endometriosis removal surgery due to endometriosis-associated chronic pain, will be randomised between post-surgery usual care with CBT and post-surgery usual care only. Participants in the CBT group will additionally receive seven sessions of CBT, focused on expectancy management, cognitions regarding pain and emotional and behavioural impact of pain. To determine the primary outcome Quality of life, both groups will complete questionnaires assessing QoL. The secondary outcomes pain intensity, pain cognitions, fatigue and perceived stress are also measured using questionnaires. Additionally, a marker for stress (cortisol extracted from a hair sample) will be assessed at T0 (baseline assessment), T1 (post-intervention; 2 weeks after completion of all CBT sessions) and T2 (follow-up; 14 weeks after T1). Statistical analysis will be performed using SPSS software.Ethics and disseminationThe study protocol has been approved by the Medical Ethical Committee of the region Arnhem-Nijmegen from the Radboud University Medical Centre on 2 September 2020. The findings of this study will be published in scientific journals and will be presented at scientific conferences.Trial registration numberNCT04448366.
Efficacy of anti-SARS-CoV-2 mRNA vaccine in systemic autoimmune disorders: induction of high avidity and neutralising anti-RBD antibodies
Authors: Tani Chiara , Pratesi Federico , Talarico Rosaria , Cardelli Chiara , Caruso Teresita , Di Cianni Federica , Laurino Elenia , Italiano Nazzareno , Moretti Michele , Manca Maria Laura , Migliorini Paola , Mosca Marta 
Published: December 2021

ObjectivesIn patients with systemic autoimmune rheumatic disorders (SARDs), vaccination with SARS-CoV-2 mRNA vaccines has been proposed. The aim of this study is to evaluate the immune response elicited by vaccination with mRNA vaccine, testing IgM, IgA and IgG antibodies to SARS-CoV-2 receptor-binding domain (RBD) and measuring neutralising antibodies.MethodsIgG, IgM and IgA anti-RBD antibodies were measured in 101 patients with SARDs. Antibodies inhibiting the interaction between RBD and ACE2 were evaluated. Antibody avidity was tested in a chaotropic ELISA using urea. Twenty-one healthcare workers vaccinated with mRNA vaccine served as control group.ResultsAnti-RBD IgG and IgA were produced after the first dose (69% and 64% of the patients) and after the boost (93% and 83%). Antibodies inhibiting the interaction of RBD with ACE2 were detectable in 40% of the patients after the first dose and 87% after boost, compared with 100% in healthy controls (p<0.01). Abatacept and mycophenolate had an impact on the titre of IgG anti-RBD antibodies (p<0.05 and p<0.005, respectively) and on the amount of neutralising antibodies. No effect of other therapies was observed. Vaccinated patients produce high avidity antibodies, as healthy controls.ConclusionsThese data show that double-dose vaccination induced in patients with SARDs anti-RBD IgG and IgA antibodies in amounts not significantly different from controls, and, most interestingly, characterised by high avidity and endowed with neutralising activity.
Effects of the COVID-19 pandemic on patients with inflammatory joint diseases in Sweden: from infection severity to impact on care provision
Authors: Bower Hannah , Frisell Thomas , di Giuseppe Daniela , Delcoigne Bénédicte , Alenius Gerd-Marie , Baecklund Eva , Chatzidionysiou Katerina , Feltelius Nils , Forsblad-d'Elia Helena , Kastbom Alf , Klareskog Lars , Lindqvist Elisabet , Lindström Ulf , Turesson Carl , Sjöwall Christopher , Askling Johan 
Published: December 2021

ObjectivesTo compare risks for COVID-19-related outcomes in inflammatory joint diseases (IJDs) and across disease-modifying antirheumatic drugs (DMARDs) during the first two waves of the pandemic and to assess effects of the pandemic on rheumatology care provision.MethodsThrough nationwide multiregister linkages and cohort study design, we defined IJD and DMARD use annually in 2015–2020. We assessed absolute and relative risks of hospitalisation or death listing COVID-19. We also assessed the incidence of IJD and among individuals with IJD, rheumatologist visits, DMARD use and incidence of selected comorbidities.ResultsBased on 115 317 patients with IJD in 2020, crude risks of hospitalisation and death listing COVID-19 (0.94% and 0.33% across both waves, respectively) were similar during both waves (adjusted HR versus the general population 1.33, 95% CI 1.23 to 1.43, for hospitalisation listing COVID-19; 1.23, 95% CI 1.08 to 1.40 for death listing COVID-19). Overall, biological disease-modifying antirheumatic drugs (bDMARDs)/targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) did not increase risks of COVID-19 related hospitalisation (with the exception of a potential signal for JAK inhibitors) or death. During the pandemic, decreases were observed for IJD incidence (−7%), visits to rheumatology units (−16%), DMARD dispensations (+6.5% for bDMARD/tsDMARDs and −8.5% for conventional synthetic DMARDs compared with previous years) and for new comorbid conditions, but several of these changes were part of underlying secular trends.ConclusionsPatients with IJD are at increased risk of serious COVID-19 outcomes, which may partially be explained by medical conditions other than IJD per se. The SARS-CoV-2 pandemic has exerted measurable effects on aspects of rheumatology care provision demonstrated, the future impact of which will need to be assessed.
Role of clinical and biochemical inflammation in structural progression of patients with psoriatic arthritis
Authors: Borst Carina , Alasti Farideh , Smolen Josef S , Aletaha Daniel 
Published: December 2021

ObjectiveTo determine the contribution of clinical and biochemical inflammation to structural progression of patients with psoriatic arthritis (PsA).MethodsWe analysed patients from the Infliximab Multinational Psoriatic Arthritis Controlled Trial 2 trial (infliximab vs placebo). We obtained total modified Sharp/van-der-Heijde Scores from baseline and year one images, and swollen joint counts (SJC) and levels of C reactive protein (CRP) throughout the second half of year 1 (5 measurements) from 74 placebo-treated patients. We computed radiographic progression, time-averaged SJC (taSJC) and CRP (taCRP) values and assessed their impact on structural progression by logistic regression analysis. We further categorised patients as ‘active’ (+) or ‘inactive’ (−) based on their taSJC (cut-off point: 2/66 joints) and taCRP (cut-off point: 0.5 mg/dL) and compared radiographic progression across three groups (double inactive, single active, double active).ResultsORs for progression were 1.24 (95 % CI 1.04 to 1.47; p=0.016) for taSJC and 6.08 (95 % CI 1.12 to 33.03; p=0.036) for taCRP. When predictors were dichotomised (+ vs −), differences were maintained between taSJC+ and taSJC− patients (1.05±3.21 and 0.56±2.30, respectively), as well as for taCRP+ vs taCRP− patients (1.14±3.23 and 0.05±2.37, respectively). Progression was intermediate in the presence of abnormalities of one but not the other inflammatory variable, indicating increasing radiographic progression with increasing inflammation (p=0.05).ConclusionIn patients with PsA, both clinical and biochemical inflammation have an impact on structural progression. Overall, progression is smallest in the absence of both clinical and biochemical inflammation, higher when either clinical or biochemical inflammation is present and highest with both clinical and biochemical inflammation.
Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea
Authors: Ahn Sung Soo , Han Minkyung , Park Yong-Beom , Jung Inkyung , Lee Sang-Won 
Published: December 2021

BackgroundTakayasu arteritis (TAK) is a disease associated with increased risk of cardiovascular complications. We aimed to evaluate the incidence, prevalence and risk of stroke in patients with TAK.MethodsData from 1065 patients were obtained from a national database (2010–2018). The annual incidence and prevalence per 100 000 persons were estimated using the registration population in the midst of every year, and the standardised incidence ratio (SIR) of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular diseases. Age-adjusted incidence rate ratio (IRR) of stroke based on the time interval after diagnosis was also calculated. A time-dependent Cox regression was conducted to investigate predictive factors of stroke.ResultsThe overall incidence rate of TAK ranged between 0.2 and 0.3/100 000 person-years annually; the prevalence of TAK gradually increased, reaching 3.25/100 000 person-years in 2018. Seventy-three (6.9%) patients experienced stroke during follow-up, and the risk of developing stroke was higher than the general population (overall SIR 7.39, 95% CI 5.79 to 9.29; men: SIR 5.70, 95% CI 2.84 to 10.20; women: SIR 7.06, 95% CI 5.41 to 9.05). Most stroke events (90.9%) were cerebral infarction for men, whereas the proportion of cerebral infarction was lower (62.9%) in women. Over half of stroke events occurred within 6 months after diagnosis, and stroke was more common within 6 months of diagnosis compared with after 3 years in women (IRR 13.46, 95% CI 6.86 to 26.40). In Cox regression analysis, age was the sole predictor of stroke (adjusted HR 1.02, 95% CI 1.00 to 1.04, p=0.043).ConclusionsThe annual incidence of TAK was similar to the previous studies from Asia, and the risk of stroke increased in TAK. Different patterns of subtype and incidence of stroke were found according to sex, although age was the only predictor.
Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion
Authors: Nie Ximing , Wang David , Pu Yuehua , Wei Yufei , Lu Qixuan , Yan Hongyi , Liu Xin , Zheng Lina , Liu Jingyi , Yang Xinxuan , Ding Yarong , Liu Dacheng , Duan Wanying , Zhang Zhe , Yang Zhonghua , Wen Miao , Gu Weibin , Hou Xinyi , Leng Xinyi , Pan Yuesong , Miao Zhongrong , Liu Liping 
Published: December 2021

Background and purposeIt remains controversial if endovascular treatment (EVT) can improve the outcome of patients with acute basilar artery occlusion (BAO). This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis (IVT) first in patients who had acute ischaemic stroke (AIS) due to BAO.MethodsPatients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study, and the efficacy and safety were compared between IVT+EVT and direct EVT. The primary outcome was 90-day functional independence. All outcomes were assessed with adjusted OR (aOR) from the multivariable logistic regression. In addition, a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.ResultsOf 310 enrolled patients with BAO, 241 (78%) were treated with direct EVT and 69 (22%) with IVT+EVT. Direct EVT was associated with a worse functional outcome (aOR, 0.46 (95% CI 0.24 to 0.85), p=0.01). IVT+EVT was associated with a lower percentage of patients who needed ≥3 passes of stent retriever (10.14% vs 20.75%). The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence (r=0.14 (95% CI 0.05 to 0.24), p<0.01).ConclusionsThis study showed that compared with direct EVT, EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset. The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.
Redescription of Ektaphelenchoides compsi Baujard, 1984 (Tylenchina: Aphelenchoididae) isolated from Pinus massoniana in Fujian Province, China
Authors: Li Hongmei , Gu Jianfeng , Fang Yiwu , Ma Xinxin , Munawar Maria 
Published: December 2021

Summary
Ektaphelenchoides compsi is redescribed morphologically with new molecular characterisation. It was isolated from a dead Pinus massoniana tree in Ningde City, Fujian Province, China. Detailed morphology of the spicule, female gonad, hemizonid position, arrangement of male caudal papillae and female tail terminus shape are documented. It is characterised by a lateral field with three lines (forming two bands), tripartite stylet 17.8 (17.0-19.4) μm long without basal thickenings, metacorpus rectangular with anterior 40% granular and posterior part weakly muscular, metacorpal valve slightly posterior to middle of metacorpus, excretory pore at level of nerve ring, vagina with thickened walls and strongly developed muscular bundles, vulval lips slightly protuberant, vulval flap absent, distal region of post-vulval uterine sac appearing as a weakly developed oogonia, anus and rectum indistinct, female posterior part (‘tail’) dorsally convex, conical, terminal region contracted into a bluntly pointed tip. The spicules are arcuate, 15.6 (14.3-16.3) μm along the chord, lamina smoothly curved to distal end, capitulum slightly concave, condylus well-developed with broadly rounded tip and slightly depressed at dorsal end, rostrum triangular with finely rounded tip, cucullus absent, and with seven caudal papillae present. The near full length 18S and 28S D2-D3 regions of rRNA genes sequences were characterised. The phylogenetic analyses revealed that the Fujian population of E. compsi grouped with the Zhejiang population of E. compsi, both being morphologically identical.
Self-Defence and a Phronetic Use of Violence: A Christian Response to Muslim-mob Attacks in Northern Nigeria
Authors: Atsen Isuwa Y. 
Published: December 2021

Abstract
The sermon on the mount has often been used to support a nonviolent response to any form of injustice and violent attacks against Christians. This article argues that the sermon, understood in its original Old and New Testament contexts, does not necessarily support a wholesale prohibition of the use of violence. It also argues that the implicit ethical theory of the sermon – and the New Testament in general – is a combination of a virtue ethics and a divine command theory. On this premise, one is able to show that a measured use of violence for self-defence is a theologically tenable Christian response to unauthorized attacks. This measured use of violence for self-defence is qualified by a Christian phronesis or practical wisdom, which takes into full account both the teaching of Jesus on love of the enemy and the contextual or existential realities of Christians facing violent attacks in northern Nigeria.
What is Early Modern History?: An Origin Story
Authors: Wiesner-Hanks Merry 
Published: December 2021

Abstract
What Is Early Modern History?, a volume in the Polity Press “What Is History?” series, is an origin story of the ways historians and those in other fields have seen – and contested – the roots of the modern world and have seen – and contested – whether the period between 1450 and 1800 forms some sort of coherent whole. This essay explains the book’s conceptualization and organization into various subfields, including economic, social, intellectual, cultural, gender, Atlantic world, and environmental history, and responds to the other essays in this forum. The essay and the book discuss the marks of an emerging modernity that have been advanced in different subfields, and ways these have been questioned, nuanced, and rethought. No matter what aspect of life historians investigate, they are likely to see the roots of modernity there, or of multiple modernities, varied and contingent on culture and historical circumstances.
The Global Early Modern
Authors: Mukherjee Rila 
Published: December 2021

Abstract
This essay, investigating India’s history within the “global early modern” from 1500 to 1800, distinguishes between the “early modern” and the “global early modern.” While the latter label is more inclusive, I conclude that changes visible in earlier periods were more radical, enabling India to participate meaningfully in the “global Middle Ages.” India showed ambivalence in negotiating the “global early modern.”
Contextualizing four-stage legal transitions in convergent evolution
Authors: Su Pengfei , Shen Wei 
Published: December 2021

Summary
This article posits that both Roman and early Chinese states underwent four stages in their multiple-step transformations from local states to major empires during the classical period. For both states, at stage 2, one dominant state formed alliance with a group of smaller autonomous polities, and at stage 3 that dominant state deepened its regulation of the smaller polities whose autonomy was curtailed. There existed striking similarities between Rome and China (early Han Empire) at stages 2 and 3 regarding the constitutional rules enforced by the two central governments to control the newly-acquired subordinate territories, which were the Macedonian/Greek states for Rome and the vassal kingdoms in eastern territories for Han Empire. In particular, this article discusses: (i) why Macedonian/Greek states have been chosen for comparative studies; (ii) similar constitutional rules at stage 2 governing the two empires’ relationships with their subordinate polities; (iii) similar legal rules at stage 3 aiming at dividing up the territories of the subordinate polities and restraining their self-rule; (iv) similar stage-3 constitutional rules that preserved some autonomy for the subordinate polities; and (v) similar stage-3 legal rules that regulated certain economic activities of the subordinate polities. After analyzing Roman governance of Macedonia/Greece within the broader context of Roman institutions for territorial integration, the article explores the underlying trends and deeper mechanism that led to such convergent evolution of legal rules.
‘In the hope to have judged a good sentence as merchants’
Authors: Fieremans Niels 
Published: December 2021

Summary
Arbitration is a form of conflict resolution that was popular in commercial disputes in medieval times. Its informal nature and ability to mediate the shortcomings of the formal courts have made it the supreme example of merchants solving their own disputes. However, there has been relatively little inquiry into its actual practice. This article investigates the functions and practice of arbitration in medieval Bruges, where arbitration was frequently used as a form of conflict resolution. This was not because merchants preferred extra-judicial proceedings, but because arbitration was a necessary procedure to deal with the shortcomings of the judicial framework of the aldermen of Bruges. Arbitration was exercised as a specific consequence of the context in which Bruges found itself in the second half of the fifteenth century. This context, however, also undermined the procedure. The ambivalent attitude of the Bruges aldermen towards arbitration and its impossibility to appeal allowed some undertaking merchants to use the procedure to their own benefit, and not necessarily to the benefit of commerce.
Points of Contact
Authors: Posegay Nick 
Published: December 2021

In the first few centuries of Islam, Middle Eastern Christians, Muslims, and Jews alike all faced the challenges of preserving their holy texts in the midst of a changing religious landscape. This situation led Syriac, Arabic, and Hebrew scholars to develop new fields of linguistic science in order to better analyse the languages of the Bible and the Qurʾān.
Part of this work dealt with the issue of vocalisation in Semitic scripts, which lacked the letters required to precisely record all the vowels in their languages. Semitic scribes thus developed systems of written vocalisation points to better record vowel sounds, first in Syriac, then soon after in Arabic and Hebrew. These new points opened a new field of linguistic analysis, enabling medieval grammarians to more easily examine vowel phonology and explore the relationships between phonetics and orthography.
Many aspects of this new field of vocalisation crossed the boundaries between religious communities, first with the spread of ‘relative’ vocalisation systems prior to the eighth century, and later with the terminology created to name the discrete vowels of ‘absolute’ vocalisation systems.
This book investigates the theories behind Semitic vocalisation and vowel phonology in the early medieval Middle East, tracing their evolution to identify points of intellectual contact between Syriac, Arabic, and Hebrew linguists before the twelfth century.