bluuebunny/crossref_metadata_2025_split huggingface dataset:
The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial
Authors: Nassif Michael E. , Windsor Sheryl L. , Borlaug Barry A. , Kitzman Dalane W. , Shah Sanjiv J. , Tang Fengming , Khariton Yevgeniy , Malik Ali O. , Khumri Taiyeb , Umpierrez Guillermo , Lamba Sumant , Sharma Kavita , Khan Sadiya S. , Chandra Lokesh , Gordon Robert A. , Ryan John J. , Chaudhry Sunit-Preet , Joseph Susan M. , Chow Chen H. , Kanwar Manreet K. , Pursley Michael , Siraj Elias S. , Lewis Gregory D. , Clemson Barry S. , Fong Michael , Kosiborod Mikhail N. 
Published: October 2021

AbstractPatients with heart failure and preserved ejection fraction (HFpEF) have a high burden of symptoms and functional limitations, and have a poor quality of life. By targeting cardiometabolic abmormalities, sodium glucose cotransporter 2 (SGLT2) inhibitors may improve these impairments. In this multicenter, randomized trial of patients with HFpEF (NCT03030235), we evaluated whether the SGLT2 inhibitor dapagliflozin improves the primary endpoint of Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CS), a measure of heart failure-related health status, at 12 weeks after treatment initiation. Secondary endpoints included the 6-minute walk test (6MWT), KCCQ Overall Summary Score (KCCQ-OS), clinically meaningful changes in KCCQ-CS and -OS, and changes in weight, natriuretic peptides, glycated hemoglobin and systolic blood pressure. In total, 324 patients were randomized to dapagliflozin or placebo. Dapagliflozin improved KCCQ-CS (effect size, 5.8 points (95% confidence interval (CI) 2.3–9.2,P = 0.001), meeting the predefined primary endpoint, due to improvements in both KCCQ total symptom score (KCCQ-TS) (5.8 points (95% CI 2.0–9.6,P = 0.003)) and physical limitations scores (5.3 points (95% CI 0.7–10.0,P = 0.026)). Dapagliflozin also improved 6MWT (mean effect size of 20.1 m (95% CI 5.6–34.7,P = 0.007)), KCCQ-OS (4.5 points (95% CI 1.1–7.8,P = 0.009)), proportion of participants with 5-point or greater improvements in KCCQ-OS (odds ratio (OR) = 1.73 (95% CI 1.05–2.85,P = 0.03)) and reduced weight (mean effect size, 0.72 kg (95% CI 0.01–1.42,P = 0.046)). There were no significant differences in other secondary endpoints. Adverse events were similar between dapagliflozin and placebo (44 (27.2%) versus 38 (23.5%) patients, respectively). These results indicate that 12 weeks of dapagliflozin treatment significantly improved patient-reported symptoms, physical limitations and exercise function and was well tolerated in chronic HFpEF.
Downscaling SSP-consistent global spatial urban land projections from 1/8-degree to 1-km resolution 2000–2100
Authors: Gao Jing , Pesaresi Martino 
Published: October 2021

AbstractLong-term, spatial urban land projections that simultaneously offer global coverage and local-scale empirical accuracy are rare. Recently a set of such projections was produced using data-science-based simulations and the Shared Socioeconomic Pathways (SSPs). These projections update at decadal time intervals from 2000 to 2100 with a spatial resolution of 1/8 degree, while many socio-environmental studies customarily run their analysis and modelling at finer spatial resolutions, e.g. 1-km. Here we develop and validate an algorithm to downscale the 1/8-degree spatial urban land projections to the 1-km resolution. The algorithm uses an iterative process to allocate the decadal amount of urban land expansion originally projected for each 1/8-degree grid to its constituent 1-km grids. The results are a set of global maps showing urban land fractions at the 1-km resolution, updated at decadal intervals from 2000 to 2100, under five different urban land expansion scenarios consistent with the SSPs. The data can support studies of potential interactions between future urbanization and environmental changes across spatial and temporal scales.
Lower-limb kinematics and kinetics during continuously varying human locomotion
Authors: Reznick Emma , Embry Kyle R. , Neuman Ross , Bolívar-Nieto Edgar , Fey Nicholas P. , Gregg Robert D. 
Published: October 2021

AbstractHuman locomotion involves continuously variable activities including walking, running, and stair climbing over a range of speeds and inclinations as well as sit-stand, walk-run, and walk-stairs transitions. Understanding the kinematics and kinetics of the lower limbs during continuously varying locomotion is fundamental to developing robotic prostheses and exoskeletons that assist in community ambulation. However, available datasets on human locomotion neglect transitions between activities and/or continuous variations in speed and inclination during these activities. This data paper reports a new dataset that includes the lower-limb kinematics and kinetics of ten able-bodied participants walking at multiple inclines (±0°; 5° and 10°) and speeds (0.8 m/s; 1 m/s; 1.2 m/s), running at multiple speeds (1.8 m/s; 2 m/s; 2.2 m/s and 2.4 m/s), walking and running with constant acceleration (±0.2; 0.5), and stair ascent/descent with multiple stair inclines (20°; 25°; 30° and 35°). This dataset also includes sit-stand transitions, walk-run transitions, and walk-stairs transitions. Data were recorded by a Vicon motion capture system and, for applicable tasks, a Bertec instrumented treadmill.
In vivo high-resolution structural MRI-based atlas of human thalamic nuclei
Authors: Saranathan Manojkumar , Iglehart Charles , Monti Martin , Tourdias Thomas , Rutt Brian 
Published: October 2021

AbstractThalamic nuclei play critical roles in regulation of neurological functions like sleep and wakefulness. They are increasingly implicated in neurodegenerative and neurological diseases such as multiple sclerosis and essential tremor. However, segmentation of thalamic nuclei is difficult due to their poor visibility in conventional MRI scans. Sophisticated methods have been proposed which require specialized MRI acquisitions and complex post processing. There are few high spatial resolution (1 mm3 or higher) in vivo MRI thalamic atlases available currently. The goal of this work is the development of an in vivo MRI-based structural thalamic atlas at 0.7 × 0.7 × 0.5 mm resolution based on manual segmentation of 9 healthy subjects using the Morel atlas as a guide. Using data analysis from healthy subjects as well as patients with multiple-sclerosis and essential tremor and at 3T and 7T MRI, we demonstrate the utility of this atlas to provide fast and accurate segmentation of thalamic nuclei when only conventional T1 weighted images are available.
A unifying view on extended phase graphs and Bloch simulations for quantitative MRI
Authors: Guenthner Christian , Amthor Thomas , Doneva Mariya , Kozerke Sebastian 
Published: October 2021

AbstractQuantitative MRI methods and learning-based algorithms require exact forward simulations. One critical factor to correctly describe magnetization dynamics is the effect of slice-selective RF pulses. While contemporary simulation techniques correctly capture their influence, they only provide final magnetization distributions, require to be run for each parameter set separately, and make it hard to derive general theoretical conclusions and to generate a fundamental understanding of echo formation in the presence of slice-profile effects. This work aims to provide a mathematically exact framework, which is equally intuitive as extended phase graphs (EPGs), but also considers slice-profiles through their natural spatial representation. We show, through an analytical, hybrid Bloch-EPG formalism, that the spatially-resolved EPG approach allows to exactly predict the signal dependency on off-resonance, spoiling moment, microscopic dephasing, and echo time. We also demonstrate that our formalism allows to use the same phase graph to simulate both gradient-spoiled and balanced SSFP-based MR sequences. We present a derivation of the formalism and identify the connection to existing methods, i.e. slice-selective Bloch, slice-selective EPG, and the partitioned EPG. As a use case, the proposed hybrid Bloch-EPG framework is applied to MR Fingerprinting.
Automated caries detection in vivo using a 3D intraoral scanner
Authors: Michou Stavroula , Lambach Mathias S. , Ntovas Panagiotis , Benetti Ana R. , Bakhshandeh Azam , Rahiotis Christos , Ekstrand Kim R. , Vannahme Christoph 
Published: October 2021

AbstractThe use of 3D intraoral scanners (IOS) and software that can support automated detection and objective monitoring of oral diseases such as caries, tooth wear or periodontal diseases, is increasingly receiving attention from researchers and industry. This study clinically validates an automated caries scoring system for occlusal caries detection and classification, previously defined for an IOS system featuring fluorescence (TRIOS 4, 3Shape TRIOS A/S, Denmark). Four algorithms (ALG1, ALG2, ALG3, ALG4) are assessed for the IOS; the first three are based only on fluorescence information, while ALG4 also takes into account the tooth color information. The diagnostic performance of these automated algorithms is compared with the diagnostic performance of the clinical visual examination, while histological assessment is used as reference. Additionally, possible differences between in vitro and in vivo diagnostic performance of the IOS system are investigated. The algorithms show comparable in vivo diagnostic performance to the visual examination with no significant difference in the area under the ROC curves ($$p>0.05$$

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>
0.05

). Only minor differences between their in vitro and in vivo diagnostic performance are noted but no significant differences in the area under the ROC curves, ($$p>0.05$$

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>
0.05

). This novel IOS system exhibits encouraging performance for clinical application on occlusal caries detection and classification. Different approaches can be investigated for possible optimization of the system.
Twitter as an innovation process with damping effect
Authors: Aletti Giacomo , Crimaldi Irene 
Published: October 2021

AbstractIn the existing literature about innovation processes, the proposed models often satisfy the Heaps’ law, regarding the rate at which novelties appear, and the Zipf’s law, that states a power law behavior for the frequency distribution of the elements. However, there are empirical cases far from showing a pure power law behavior and such a deviation is mostly present for elements with high frequencies. We explain this phenomenon by means of a suitable “damping” effect in the probability of a repetition of an old element. We introduce an extremely general model, whose key element is the update function, that can be suitably chosen in order to reproduce the behaviour exhibited by the empirical data. In particular, we explicit the update function for some Twitter data sets and show great performances with respect to Heaps’ law and, above all, with respect to the fitting of the frequency-rank plots for low and high frequencies. Moreover, we also give other examples of update functions, that are able to reproduce the behaviors empirically observed in other contexts.
Identification of adipocytes as target cells for Leishmania infantum parasites
Authors: Schwing Aurélie , Pisani Didier F. , Pomares Christelle , Majoor Alissa , Lacas-Gervais Sandra , Jager Jennifer , Lemichez Emmanuel , Marty Pierre , Boyer Laurent , Michel Grégory 
Published: October 2021

AbstractLeishmania infantum is the causative agent of visceral leishmaniasis transmitted by the bite of female sand flies. According to the WHO, the estimated annual incidence of leishmaniasis is one million new cases, resulting in 30,000 deaths per year. The recommended drugs for treating leishmaniasis include Amphotericin B. But over the course of the years, several cases of relapses have been documented. These relapses cast doubt on the efficiency of actual treatments and raise the question of potential persistence sites. Indeed, Leishmania has the ability to persist in humans for long periods of time and even after successful treatment. Several potential persistence sites have already been identified and named as safe targets. As adipose tissue has been proposed as a sanctuary of persistence for several pathogens, we investigated whether Leishmania infantum could be found in this tissue. We demonstrated both in cell cultures and in vivo that Leishmania infantum was able to infect adipocytes. Altogether our results suggest adipocytes as a ‘safe target’ for Leishmania infantum parasites.
Crustal velocity and interseismic strain-rate on possible zones for large earthquakes in the Garhwal–Kumaun Himalaya
Authors: Pappachen John P. , Sathiyaseelan Rajesh , Gautam Param K. , Pal Sanjit Kumar 
Published: October 2021

AbstractThe possibility of a major earthquake like 2015 Gorkha–Nepal or even greater is anticipated in the Garhwal–Kumaun region in the Central Seismic Gap of the NW Himalaya. The interseismic strain-rate from GPS derived crustal velocities show multifaceted strain-rate pattern in the region and are classified into four different strain-rate zones. Besides compressional, we identified two NE–SW orienting low strain rate (~ 20 nstrain/a) zones; namely, the Ramganga-Baijro and the Nainital-Almora, where large earthquakes can occur. These zones have surface locking widths of ~ 72 and ~ 75 km respectively from the Frontal to the Outer Lesser Himalaya, where no significant surface rupture and associated large earthquakes were observed for the last 100 years. However, strain reducing extensional deformation zone that appears sandwiched between the low strain-rate zones pose uncertainties on the occurences of large earthquakes in the locked zone. Nevertheless, such zone acts as a conduit to transfer strain from the compressional zone (> 100 nstrain/a) to the deforming frontal active fault systems. We also observed a curvilinear surface strain-rate pattern in the Chamoli cluster and explained how asymmetric crustal accommodation processes at the northwest and the southeast edges of the Almora Klippe, cause clockwise rotational couple on the upper crust moving over the MHT.
Recognition of post-learning alteration of hippocampal ripples by convolutional neural network differs in the wild-type and AD mice
Authors: Hsu Sheng-Yi , Jura Bartosz , Shih Mau-Hsiang , Meyrand Pierre , Tsai Feng-Sheng , Bem Tiaza 
Published: October 2021

AbstractEvidence indicates that sharp-wave ripples (SWRs) are primary network events supporting memory processes. However, some studies demonstrate that even after disruption of awake SWRs the animal can still learn spatial task or that SWRs may be not necessary to establish a cognitive map of the environment. Moreover, we have found recently that despite a deficit of sleep SWRs the APP/PS1 mice, a model of Alzheimer’s disease, show undisturbed spatial reference memory. Searching for a learning-related alteration of SWRs that could account for the efficiency of memory in these mice we use convolutional neural networks (CNN) to discriminate pre- and post-learning 256 ms samples of LFP signals, containing individual SWRs. We found that the fraction of samples that were correctly recognized by CNN in majority of discrimination sessions was equal to ~ 50% in the wild-type (WT) and only 14% in APP/PS1 mice. Moreover, removing signals generated in a close vicinity of SWRs significantly diminished the number of such highly recognizable samples in the WT but not in APP/PS1 group. These results indicate that in WT animals a large subset of SWRs and signals generated in their proximity may contain learning-related information whereas such information seem to be limited in the AD mice.
Impact of total splenectomy on peripheral lymphocytes and their subsets in patients with hypersplenism associated with cirrhotic portal hypertension
Authors: Lv Yunfu , Wu Hongfei , Lau Wan Yee , Zheng Jinfang , Wu Jincai , Zeng Min 
Published: October 2021

AbstractTo study the impact of total splenectomy (TS) on peripheral lymphocytes and their subsets in patients with hypersplenism associated with cirrhotic portal hypertension (CPH). We studied 102 consecutive patients who received TS from January 2008 to January 2020 due to CPH-related hypersplenism. A similar number of healthy individuals are used as healthy controls (HC). The total lymphocyte counts and their percentages of B lymphocytes, total T lymphocytes (cluster of differentiation (CD)3+) and their subsets (CD4+, CD8+), and natural killer (NK) cells in preoperative peripheral blood samples in hypersplenism patients were significantly lower than that of the HCs (both P < 0.05). The total lymphocyte counts and percentages of B lymphocytes in peripheral blood were significantly increased 1 week and 1 month after TS when compared with the pre-TS values (P < 0.05). There was no significant difference in the percentages of NK cells before or after surgery (P > 0.05). However, the percentages of CD3+ cells was significantly higher 1 month after than before surgery (P < 0.001). The percentages of CD4+, and CD8+ T lymphocytes were significantly lower 1 week after surgery (P < 0.05), but they were significantly higher 1 month after surgery (P < 0.01). The CD4+:CD8+ ratio was not significantly different from those before surgery, and 1 week or 1 month after surgery (P > 0.05). Patients with hypersplenism associated with CPH were significantly immunosuppressed preoperatively. After TS, the total lymphocyte count and percentages of B lymphocytes, and total T lymphocytes and their subsets increased significantly, resulting in improved immune functions.
Intraspecific variation in thermal tolerance differs between tropical and temperate fishes
Authors: Nati J. J. H. , Svendsen M. B. S. , Marras S. , Killen S. S. , Steffensen J. F. , McKenzie D. J. , Domenici P. 
Published: October 2021

AbstractHow ectothermic animals will cope with global warming is a critical determinant of the ecological impacts of climate change. There has been extensive study of upper thermal tolerance limits among fish species but how intraspecific variation in tolerance may be affected by habitat characteristics and evolutionary history has not been considered. Intraspecific variation is a primary determinant of species vulnerability to climate change, with implications for global patterns of impacts of ongoing warming. Using published critical thermal maximum (CTmax) data on 203 fish species, we found that intraspecific variation in upper thermal tolerance varies according to a species’ latitude and evolutionary history. Overall, tropical species show a lower intraspecific variation in thermal tolerance than temperate species. Notably, freshwater tropical species have a lower variation in tolerance than freshwater temperate species, which implies increased vulnerability to impacts of thermal stress. The extent of variation in CTmax among fish species has a strong phylogenetic signal, which may indicate a constraint on evolvability to rising temperatures in tropical fishes. That is, in addition to living closer to their upper thermal limits, tropical species may have higher sensitivity and lower adaptability to global warming compared to temperate counterparts. This is evidence that freshwater tropical fish communities, worldwide, are especially vulnerable to ongoing climate change.
Directional motion of the foam carrying oils driven by the magnetic field
Authors: Dou Xiaoxiao , Chen Zhewen , Zuo Pingcheng , Cao Xiaojian , Liu Jianlin 
Published: October 2021

AbstractFoams are substances widely used the foam flooding technology, which aim to greatly improve the residual oil recovery. In the present study, we perform a comprehensive investigation on the oil removal process driven by the foam embedded with magnetic particles, under the action of the magnetic force. The experiment shows that the addition of magnetic particles has little effect on the stability of the foam. During the motion of the foam, its maximum displacement and maximum acceleration are fully explored. Such factors as the volume of the foam, the volume of the oil droplet, the mass concentration of magnetic particles, and the Young’s contact angle of surfactant on solid are surveyed in detail. The function curves of the maximum displacement and the maximum acceleration with respect to these variables are obtained in the experiment, and the selection of some optimal parameters is advised. Moreover, the dimensional analysis has been conducted and several scaling laws are given, which are in agreement with the experimental results. These findings are beneficial to understand the oil displacement with the aid of magnetic field, which also provide some inspirations on drug delivery, robots and micro-fluidics.
Internal morphology of 101 mandibular canines of a Swiss-German population by means of micro-CT: An ex vivo study
Authors: Wolf Thomas Gerhard , Anderegg Andrea Lisa , Haberthür David , Khoma Oleksiy-Zakhar , Schumann Sven , Boemke Nane , Wierichs Richard Johannes , Hlushchuk Ruslan 
Published: October 2021

AbstractThe aim of this study was to investigate the root canal system morphology by means of a root canal configuration (RCC) classification described with a four-digit system, the physiological foramen geometry and accessory canal frequency and morphology, of 101 mandibular canines (MaCa) of a Swiss-German population by means of micro-computed tomography. Micro-CT examination of the MaCa was performed and the obtained images analyzed with a 3D imaging software. In single-rooted MaCas, the most frequently observed RCCs were 1-1-1/1 (74.5%) and 1-1-1/2 (14.3%). Seven other RCCs were less frequently observed with a frequency from 4.1 to 1.0%. One physiological foramen was observed in 80.6% of the MaCas, two in 16.3%, three in 1.0% and four in 2.0%. Accessory and connecting canals were apparent only in the middle and apical root thirds. Two-rooted MaCas occurred less frequently (n = 3). When one physiological foramen was present, the mean size of the narrow and wide diameters were 0.28 mm (± 0.07) and 0.40 mm (± 0.11), while the distance between physiological and anatomical foramen was 0.45 mm (± 0.17). MaCas are predominantly single-rooted teeth with a 1-1-1/1 or 1-1-1/2 RCC. Most MaCas had one physiological foramen with an oval shape.
Effect of vein-bionic surface textures on the tribological behavior of cylindrical roller thrust bearing under starved lubrication
Authors: Long Risheng , Zhao Chao , Zhang Yimin , Wang Yibing , Wang Yueyong 
Published: October 2021

AbstractTo reveal the effect of vein-bionic surface textures on the tribological behavior of cylindrical roller thrust bearings (CRTBs) under starved lubrication, six kinds of leaves (Forsythia, Clausena lansiu, Ash, Purple leaf plum, Pipal and Apricot) were chose and their simplified patterns were fabricated on the shaft washers of CRTBs using laser surface texturing. The coefficients of friction (COFs) of vein-bionic textured bearings were measured using a vertical universal wear test rig. Their mass losses and worn surfaces were also characterized. The results show that: There is important influence of the symmetry of vein-bionic textures and the number of secondary veins on the friction and wear properties of vein-bionic textured CRTBs under starved lubrication. Compared to the smooth group, the COFs and mass losses of vein-bionic textured bearings are all reduced. Among all groups, the tribological performance of bearings with a pattern inspired from Ash is the best. Its wear loss is reduced by 16.23% and its COF is reduced by 15.79%. This work would provide a valuable reference for the raceway design and optimization of roller rolling element bearings.