bluuebunny/crossref_metadata_2025_split huggingface dataset:
La historia de las personas: reflexiones desde la historiografía y de la didáctica de las ciencias sociales durante los últimos 25 años
Authors: Massip Sabater Mariona , Castellví Mata Jordi , Pagès Blanch Joan 
Published: February 2021

En este artículo se revisa la evolución de la ciencia histórica y de la historia escolar a lo largo de los últimos 25 años. Esta revisión se centra en los avances en la investigación y la enseñanza de la historia de las personas; es decir, aquella que atiende a la totalidad de agentes sociales e históricos, que se articula a partir de la proyección global de la humanidad y que atiende a los problemas de las experiencias humanas. En primer lugar, se concreta el concepto de historia escolar y se explica la relación que se establece entre la historia escolar y la historiografía. En segundo lugar, se analiza la evolución de ambas a lo largo de estos 25 años. Finalmente, se plantean retos de futuro. Existe un desequilibrio entre la evolución del conocimiento histórico y el impacto que ha tenido en el currículo escolar. La historia escolar sigue centrada, de manera mayoritaria, en los procesos políticos nacionales, y reproduciendo saberes androcéntricos y eurocéntricos en los que se excluyen la gran mayoría de protagonistas.
In this article the evolution of historical science and school history over the past 25 years is reviewed. This review focuses on advances in people's history; that is, a history in which all social and historical agents are recognised, and which is articulated from the global consideration of humanity and human experiences. In the first place, the meaning of school history is specified, along with the relationship between school history and historiography. Secondly, the evolution of both over these 25 years is analysed. Finally, we pose future challenges.
There is an imbalance between the evolution of historical knowledge and the impact it has had on the school curriculum and educational practices. School history continues to reproduce androcentric and Eurocentric knowledge based on political processes in which the great majority of protagonists are excluded.
The natural product biosynthetic potential of Red Sea nudibranch microbiomes
Authors: Abdelrahman Samar M. , Patin Nastassia V. , Hanora Amro , Aboseidah Akram , Desoky Shimaa , Desoky Salha G. , Stewart Frank J. , Lopanik Nicole B. 
Published: February 2021

BackgroundAntibiotic resistance is a growing problem that can be ameliorated by the discovery of novel drug candidates. Bacterial associates are often the source of pharmaceutically active natural products isolated from marine invertebrates, and thus, important targets for drug discovery. While the microbiomes of many marine organisms have been extensively studied, microbial communities from chemically-rich nudibranchs, marine invertebrates that often possess chemical defences, are relatively unknown.MethodsWe applied both culture-dependent and independent approaches to better understand the biochemical potential of microbial communities associated with nudibranchs. Gram-positive microorganisms isolated from nudibranchs collected in the Red Sea were screened for antibacterial and antitumor activity. To assess their biochemical potential, the isolates were screened for the presence of natural product biosynthetic gene clusters, including polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) genes, using PCR. The microbiomes of the nudibranchs were investigated by high-throughput sequencing of 16S rRNA amplicons.ResultsIn screens against five model microorganisms, 51% of extracts displayed antimicrobial activity against more than one organism, and 19% exhibited antitumor activity against Ehrlich’s ascites carcinoma. Sixty-four percent of isolates contained PKS and NRPS genes, suggesting their genomes contain gene clusters for natural product biosynthesis. Thirty-five percent were positive for more than one class of biosynthetic gene. These strains were identified as belonging to the Firmicutes and Actinobacteria phyla via 16S rRNA gene sequencing. In addition, 16S rRNA community amplicon sequencing revealed all bacterial isolates were present in the uncultured host-associated microbiome, although they were a very small percentage of the total community. Taken together, these results indicate that bacteria associated with marine nudibranchs are potentially a rich source of bioactive compounds and natural product biosynthetic genes.
Drug‐induced liver injury in the era of biologics: The case of natalizumab
Authors: Taveira Filipe , Lopes Sandra , Faria Carlos , Mendes Sofia , Figueiredo Pedro 
Published: February 2021

AbstractDrug‐induced liver injury (DILI) is a challenging diagnosis regarding the complexity of mechanisms, drugs, supplements, and herbs that can have hepatotoxic potential. Biologics are increasing as common drugs in the treatment of chronic inflammatory diseases and some DILI were previously reported with those agents. Natalizumab, a recombinant monoclonal antibody used for the treatment of multiple sclerosis (MS) has a good safety profile with extremely rare liver‐related adverse events. The clinical case of a 44‐year‐old female with the history of MS and the recent start of natalizumab was reported. The patient was admitted with jaundice, choluria, fatigue, anorexia, nausea, and diffuse abdominal discomfort. No signs of encephalopathy or MS flare on examination. Laboratory values: aspartate aminotransferase, 905 U/L; alanine transaminase, 1559 U/L; ALP, 127 U/L; GGT, 301 U/L; total bilirubin, 12.8 mg/dL; direct bilirubin, 5.9 mg/dL, Albumin 2.9 g/dL, platelet 137 g/L, and 2.44 INR. No infectious, vascular, metabolic causes, or biliary obstruction were found. Liver biopsy suggested toxic hepatitis with autoimmune features. Since no definite criteria for autoimmune hepatitis (AH) were met, steroids were not given. The patient was on supportive measures and was presented to a liver transplant unit. Therefore, DILI due to natalizumab was assumed and its discontinuation led to the resolution of all symptoms in a 6‐month window. The increasingly common use of biological therapy or with direct influence on the immune system should raise the suspicion of the gastroenterologist in all cases of suspected DILI.
Predictive ability of four small‐scale quality tests for dough rheological properties and baking quality in hard red spring wheat
Authors: Daba Sintayehu D. , Simsek Senay , Green Andrew J. 
Published: February 2021

AbstractBackground and ObjectivesPredictive models for use in early generation hard spring wheat breeding were evaluated for Farinograph and baking quality. Flour samples were prepared on the Quadrumat Jr. and Buhler mill from 48 genotypes grown at four locations in North Dakota.FindingsModels developed from 13 predictor variables from GlutoPeak, Glutomatic, Near Infrared Reflectance (NIR), and Solvent Retention Capacity (SRC) predicted Farinograph water absorption (ABS) and baking absorption (BA) with cross‐validated prediction accuracies of 0.71 and 0.58, respectively. For Farinograph peak time (PT), Farinograph Stability (STAB), mixing time (MT), and loaf volume (LV), the prediction accuracies were high in the model development dataset (r2 ranging from 0.60 to 0.76). However, in the cross‐validation set, the prediction accuracies only ranged from 0.30 to 0.48.ConclusionsGlutoPeak parameters can be used to predict ABS and BA in early breeding stages. Prediction of stability and peak time showed potential, and models should be improved to better predict mixing time and loaf volume.Significance and noveltyResults from a multi‐location trial involving a large number of genotypes are needed to validate the prediction accuracy for end‐use traits in hard red spring wheat. Comparing results from different mill types and diverse genotypes ensures broad applicability.
Pharmacokinetics and Safety of Dapoxetine Hydrochloride in Healthy Chinese Men: Impact of Dose and High‐Fat Meal
Authors: Liu Jingyan , Li Zhihui , Yan Keyu , Ju Gehang , Qiu Wen 
Published: February 2021

AbstractDapoxetine is the first oral medication specifically developed for the on‐demand treatment of premature ejaculation. The pharmacokinetics and safety of 30 mg (n = 40) and 60 mg (n = 38) dapoxetine in healthy Chinese under fasted and fed states were assessed in 2 studies. Both studies are random, single‐center, 2‐period, open‐label, 2‐way crossover designs. Plasma concentration of dapoxetine was determined by high‐performance liquid chromatography–tandem mass spectrometry, and the pharmacokinetic parameters were calculated using noncompartmental analysis. Dapoxetine was quickly absorbed and reached maximum concentration 1 to 3 hours after oral administration. Elimination was biphasic, and the plasma concentration decreased to 3% to 7% of maximum concentration by 24 hours while half‐life was 15 to 18 hours. Meantime, high‐fat meals slightly increased its exposure. Both doses of dapoxetine were well tolerated. The adverse events in the high‐dose group under fasted and fed states were 37.9% and 19.0%, respectively.
Transformation of Corn Lignin into Sun Cream Ingredients
Authors: Yang See Jie , Song Song , Xiao Yiying , Trang Pham Thuy , Zhao Yu , Lapkin Alexei , Yan Ning 
Published: February 2021

AbstractProduction of value‐added chemicals from lignocellulose is one of the key strands of the emerging bio‐economy. A synthetic approach has been developed to produce p‐methoxy coumarate esters from waste corn stover and corn bran, and further transform these compounds into consumer products. In the first step, p‐coumaric acid (pCA) and ferulic acid (FA) are released through mild alkaline hydrolysis of corn waste, in more than 20 mg g−1 yield (10 wt % based on lignin content). Subsequently, heterogeneous solid acids catalyze the esterification of pCA with various alcohols. Amberlite IR‐15 shows the best catalytic performance, owing to its optimal acid density, large surface area, and suitable pore diameter. The solid acid catalyst can be recycled with slight activity loss and regenerated by acid washing and vacuum drying. Finally, methylation of p‐coumarate ester to give target product p‐methoxy coumarate esters is carried out by using commercially available and low‐cost inorganic bases (e. g., K2CO3). Base‐catalyzed transesterification of methyl p‐methoxy coumarate to p‐methoxy coumarate esters is also investigated.
Intensification of Photobiocatalytic Decarboxylation of Fatty Acids for the Production of Biodiesel
Authors: Duong Hong T. , Wu Yinqi , Sutor Alexander , Burek Bastien O. , Hollmann Frank , Bloh Jonathan Z. 
Published: February 2021

AbstractLight‐driven biocatalytic processes are notoriously hampered by poor penetration of light into the turbid reaction media. In this study, wirelessly powered light‐emitting diodes are found to represent an efficient and scalable approach for process intensification of the photobiosynthetic production of diesel alkanes from renewable fatty acids.
The trickle‐down effect of procedural fairness on perceptions of daily discrimination: How societal actors can build social trust among minority members
Authors: Dierckx Kim , Valcke Barbara , Van Hiel Alain 
Published: February 2021

AbstractThe present research investigated the trickle‐down effect of procedural fairness enacted by societal institutions on minority members’ social trust. Building on the racial identity development hypothesis, we argued that procedural fairness represents a racial socialization experience, which influences how minorities perceive discrimination in daily life. Perceived group discrimination, in turn, impacts social trust. The results of five studies with African American samples corroborated the hypothesized mediation model. Study 1 showed that minority members distinctly perceive fairness enacted by institutions and discrimination by fellow citizens. Subsequent studies demonstrated that manipulating procedural fairness influenced perceived discrimination in an “attribution‐to‐discrimination” paradigm (Study 2), and that inducing discrimination lowered trust in an allocation game (Study 3). Finally, Studies 4 and 5 obtained cross‐sectional evidence for the full model. Our results thus contribute to literature by showing that perceived discrimination mediates the relationship between procedural fairness and social trust. Societally relevant practical implications are discussed.
Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines
Authors: Yang Youfeng , Ricketts Christopher J. , Vocke Cathy D. , Killian J. Keith , Padilla‐Nash Hesed M. , Lang Martin , Wei Darmood , Lee Young H. , Wangsa Darawalee , Sourbier Carole , Meltzer Paul S. , Ried Thomas , Merino Maria J. , Metwalli Adam R. , Ball Mark W. , Srinivasan Ramaprasad , Linehan W. Marston 
Published: February 2021

AbstractRenal cell carcinoma (RCC) is not a single disease but is made up of several different histologically defined subtypes that are associated with distinct genetic alterations which require subtype specific management and treatment. Papillary renal cell carcinoma (pRCC) is the second most common subtype after conventional/clear cell RCC (ccRCC), representing ~20% of cases, and is subcategorized into type 1 and type 2 pRCC. It is important for preclinical studies to have cell lines that accurately represent each specific RCC subtype. This study characterizes seven cell lines derived from both primary and metastatic sites of type 1 pRCC, including the first cell line derived from a hereditary papillary renal carcinoma (HPRC)‐associated tumor. Complete or partial gain of chromosome 7 was observed in all cell lines and other common gains of chromosomes 16, 17, or 20 were seen in several cell lines. Activating mutations of MET were present in three cell lines that all demonstrated increased MET phosphorylation in response to HGF and abrogation of MET phosphorylation in response to MET inhibitors. CDKN2A loss due to mutation or gene deletion, associated with poor outcomes in type 1 pRCC patients, was observed in all cell line models. Six cell lines formed tumor xenografts in athymic nude mice and thus provide in vivo models of type 1 pRCC. These type 1 pRCC cell lines provide a comprehensive representation of the genetic alterations associated with pRCC that will give insight into the biology of this disease and be ideal preclinical models for therapeutic studies.
Institutional quality and social cost of intermediation in Africa: Does the level of financial market development matter?
Authors: Karikari Nana Kwasi , Gyan Kwadwo Kwakye , Khan Muhammad Ahad Hayat , Kusi Baah Aye 
Published: February 2021

AbstractThis article examines the effect of institutional quality on social cost of intermediation in high and low developed financial markets across 29 African countries between 2006 and 2013. Employing bootstrap‐quantile and two‐step system generalized methods of moments models with bank level data of about 330 banks, the results provide interesting and new insights. The results show that improvement in institutional quality in high or low developed financial markets translates into reduced social cost of intermediation to the society. However, it is evident from the results that improvement in institutional quality is more robust, persistent and weightier in reducing the social cost of intermediation in low developed financial markets which are often characterized with weak regulatory regimes and enforcement. Hence, improvement in institutional quality shores up regulatory supervision, monitoring and enforcement which translates into heavier dampening of social cost of financial intermediation in less developed financial markets. Moreover, bank size, credit shocks, return on equity and liquidity are key drives of social cost of intermediation both in low and high developed financial markets. These findings have policy implications and recommendations for policymakers and regulators of financial institutions. Policymakers and regulators, especially those in less developed financial markets, must endeavour to create, implement and advance mechanisms and enabling environment that enhances the quality of institutions since improved institutional quality reduces social cost of intermediation to the benefit of society.
Role of endocytosis and trans-endocytosis in ICOS costimulator-induced downmodulation of the ICOS Ligand
Authors: Aragoneses-Fenoll Laura , Montes-Casado María , Ojeda Gloria , García-Paredes Lucía , Arimura Yutaka , Yagi Junji , Dianzani Umberto , Portolés Pilar , Rojo José M 
Published: February 2021

AbstractThe interaction between the T-lymphocyte costimulatory molecule ICOS and its ligand (ICOS-L) is needed for efficient immune responses, but expression levels are tightly controlled, as altered expression of ICOS or ICOS-L may lead to immunodeficiency, or favor autoimmune diseases and tumor growth.Using cells of mouse B cell lymphoma (M12.C3) and melanoma (B16), or hamster CHO cells transfected with various forms of mouse ICOS-L, and ICOS+ T cell lines, we show that, within minutes, ICOS induces significant downmodulation of surface ICOS-L that is largely mediated by endocytosis and trans-endocytosis. So, after interaction with ICOS+ cells, ICOS-L was found inside permeabilized cells, or in cell lysates, with significant transfer of ICOS from ICOS+ T cells to ICOS-L-expressing cells, and simultaneous loss of surface ICOS by the T cells. Data from cells expressing ICOS-L mutants show that conserved, functionally important residues in the cytoplasmic domain of mouse ICOS-L (Arg300, Ser307 and Tyr308), or removal of ICOS-L cytoplasmic tail have minor effect on its internalization.Internalization was dependent on temperature, and was partially dependent on actin polymerization, the GTPase dynamin, protein kinase C, or the integrity of lipid rafts. In fact, a fraction of ICOS-L was detected in lipid rafts. On the other hand, proteinase inhibitors had negligible effects on early modulation of ICOS-L from the cell surface.Our data add a new mechanism of control of ICOS-L expression to the regulation of ICOS-dependent responses.
Diabetes predicts severity of COVID‐19 infection in a retrospective cohort: A mediatory role of the inflammatory biomarker C‐reactive protein
Authors: Koh Huilin , Moh Angela Mei Chung , Yeoh Ester , Lin Yi , Low Serena Kiat Mun , Ooi Say Tat , Tan Seng Kiong , Lin Jaime Hui Xian , Hoong Caroline Wei Shan 
Published: February 2021

AbstractDiabetes is a risk factor for developing severe COVID‐19, but the pathogenesis remains unclear. We investigated if the association of diabetes and COVID‐19 severity may be mediated by inflammation. We also hypothesized that this increased risk may extend to prediabetes. Hospitalized patients in Singapore with COVID‐19 were subdivided into three groups in a retrospective cohort: normoglycemia (HbA1c: ≤5.6%), prediabetes (HbA1c: 5.7%–6.4%) and diabetes (HbA1c: ≥6.5%). The primary outcome of severe COVID‐19 was defined by respiratory rate ≥30, SpO2 ≤93% or intensive care unit admission. The association between clinical factors on severe COVID‐19 outcome was analyzed by cox regression. Adjusted mediation analysis of C‐reactive protein (CRP) on the relationship between diabetes and severe COVID‐19 was performed. Of 1042 hospitalized patients, mean age 39 ± 11 years, 13% had diabetes, 9% prediabetes and 78% normoglycemia. Severe COVID‐19 occurred in 4.9% of subjects. Compared to normoglycemia, diabetes was significantly associated with severe COVID‐19 on both univariate (hazard ratio [HR]: 9.94; 95% confidence interval [CI]: 5.54–17.84; p < .001) and multivariate analysis (HR: 3.99; 95% CI: 1.92–8.31; p < .001), while prediabetes was not a risk factor (HR: 0.94; 95% CI: 0.22–4.03; p = .929). CRP, a biomarker of inflammation, mediated 32.7% of the total association between diabetes and severe COVID‐19 outcome. In conclusion, CRP is a partial mediator of the association between diabetes and severe COVID‐19 infection, confirming that inflammation is important in the pathogenesis of severe COVID‐19 in diabetes.
Development and validation of clinical prediction model to estimate the probability of death in hospitalized patients with COVID‐19: Insights from a nationwide database
Authors: Tanboğa Ibrahim Halil , Canpolat Uğur , Çetin Elif Hande Özcan , Kundi Harun , Çelik Osman , Çağlayan Murat , Ata Naim , Özeke Özcan , Çay Serkan , Kaymaz Cihangir , Topaloğlu Serkan 
Published: February 2021

AbstractIn the current study, we aimed to develop and validate a model, based on our nationwide centralized coronavirus disease 2019 (COVID‐19) database for predicting death. We conducted an observational study (CORONATION‐TR registry). All patients hospitalized with COVID‐19 in Turkey between March 11 and June 22, 2020 were included. We developed the model and validated both temporal and geographical models. Model performances were assessed by area under the curve‐receiver operating characteristic (AUC‐ROC or c‐index), R2, and calibration plots. The study population comprised a total of 60,980 hospitalized COVID‐19 patients. Of these patients, 7688 (13%) were transferred to intensive care unit, 4867 patients (8.0%) required mechanical ventilation, and 2682 patients (4.0%) died. Advanced age, increased levels of lactate dehydrogenase, C‐reactive protein, neutrophil–lymphocyte ratio, creatinine, albumine, and D‐dimer levels, and pneumonia on computed tomography, diabetes mellitus, and heart failure status at admission were found to be the strongest predictors of death at 30 days in the multivariable logistic regression model (area under the curve‐receiver operating characteristic = 0.942; 95% confidence interval: 0.939–0.945; R2 = .457). There were also favorable temporal and geographic validations. We developed and validated the prediction model to identify in‐hospital deaths in all hospitalized COVID‐19 patients. Our model achieved reasonable performances in both temporal and geographic validations.
Bioactive peptides in ripened cheeses: release during technological processes and resistance to the gastrointestinal tract
Authors: Baptista Débora Parra , Gigante Mirna Lúcia 
Published: February 2021

AbstractMilk proteins are recognized as the main source of biologically active peptides. Casein's primary structure contains several bioactive amino acid sequences on its latent inactive form. These potential active sequences can be released during cheese manufacture and ripening, giving rise to peptides with biological activity such as antihypertensive, antidiabetic, antioxidant, immunomodulatory, and mineral‐binding properties. However, the presence of biopeptides in cheese does not imply actual biological activity in vivo because these peptides can be further hydrolyzed during gastrointestinal transit. This paper reviews the recent advances in biopeptide formation in ripened cheeses production, focusing on the influence of technological parameters affecting proteolysis and the consequent release of peptides. The main discoveries in the field of cheese peptide digestion through recent in vivo and in vitro model studies are also reviewed. © 2021 Society of Chemical Industry