bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual-Block Elastic Stain Significantly Increasing Visceral Pleural Invasion(VPI) Positivity and Analysis of Potential Predictors of VPI in Peripheral Non-Small Cell Lung Cancer
Authors: Li Shaoling , Huang Yan , Zhang Liping , Dong Zhengwei , Wu Wei , Zhang Wei , Wu Chunyan , Hou Likun 
Published: September 2021

Abstract
Background: Visceral pleural invasion (VPI) is a critical component in the staging of peripheral non–small cell lung carcinoma (NSCLC). Single tumor tissue block for elastic stain is conducive to identifying pleural invasion in routine pathologic examination. We aim to investigate whether dual-block elastic stain increase VPI positivity compared with single-block elastic stain, further analyze the potential predictors of VPI status.Methods: Resected 8419 consecutive peripheral NSCLC cases including tumor size≤3cm 6008 patients were retrospectively reviewed. Total cases were divided into a cohort using one tumor tissue paraffin block (single-block group, n=5184) and a cohort using dual tumor tissue paraffin blocks (dual-block group, n=3235) for elastic stain. Each case was performed with Victoria-blue van Gieson staining to assess VPI status. The clinicopathologic features of patients were collected from the electronic medical record system.Results: The overall incidence of VPI was 12.4% (1047/8419) in peripheral NSCLC patients. The VPI positivity detected by dual-block elastic stain was significantly higher than that by single-block elastic stain (17.7% (573/3235) v.s. 9.1% (474/5184), P＜0.001). The presence of VPI in T1 ≤3cm patients detected by single and dual block elastic stain was 6.3% (235/3730) and 12.0% (273/2278), respectively (P＜0.001). Therefore, 5.7% T1 patients (stage IA) are additionally upstaged to T2a (stage IB) by dual block elastic stain. But the incidence of VPI in pT2a patients had no significant difference between single-block group and dual-block group (16.8% vs 17.1%, P=0.916). The lymphovascular invasion, lymph node metastasis, poor differentiated carcinomas and the presence of STAS status could be well significant predictors of VPI (P＜0.001). Area under the ROC curve of adenocarcinoma morphology was 0.263 for lepidic pattern, 0.544 for acinar and papillary pattern, and 0.720 for micropapillary and solid pattern in predicting invasion of pleura.Conclusion: Our results indicated that using dual-block elastic stain identify more VPI positive T1 NSCLC patients who are upstaged to T2a and could benefit from optimal management after post-operation. The application of dual-block elastic stain is an efficient and practical method to detect VPI, especially for patients with high-risk prognostic factors.
Sensitivity of The Stripe-Faced Dunnart, Sminthopsis Macroura (Gould 1845), To The Phenyl Pyrazole Insecticide, Fipronil, Toxicological Signs And Implications For Pesticide Risk Assessments In Australia
Authors: Story Paul , Hinds Lyn A , Henry Steve , Warden Andrew C. , Dojchinov Greg 
Published: September 2021

Abstract
A lack of toxicity data quantifying responses of Australian native mammals to agricultural pesticides prompted an investigation into the sensitivity of the stripe-faced dunnart, Sminthopsis macroura (Gould 1845) to the insecticide, fipronil (5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinyl pyrazole, CAS No. 120068-37-3). Using the Up-And-Down method for determining acute oral toxicity in mammals, derived by the Organisation for Economic Cooperation and Development (OECD), median lethal dose estimates of 990 mg kg− 1 (95% confidence interval (CI) = 580.7–4770.0 mg kg− 1) and 270.4 mg kg− 1 (95% CI = 0.0 - >20000.0 mg kg− 1) were resolved for male and female S. macroura respectively. The difference between median lethal dose estimates for males and females may have been influenced by the increased age of two female dunnarts. Further modelling of female responses to fipronil doses used the following assumptions: (a) death at 2000 mg kg− 1, (b) survival at 500 mg kg− 1 and (c) a differential response (both survival and death) at 990 mg kg− 1. This modelling revealed median lethal dose estimates for female S. macroura of 669.1 mg kg− 1 (95% CI = 550–990 mg kg− 1; assuming death at 990 mg kg− 1) and 990 mg kg− 1 (95% CI = 544.7–1470 mg kg− 1; assuming survival at 990 mg kg− 1). These median lethal dose estimates are 3–10-fold higher than the only available LD50 value for a similarly sized eutherian mammal, Mus musculus (L. 1758; 94 mg kg− 1) and that available for Rattus norvegicus (Birkenhout 1769; 97 mg kg− 1). Implications for pesticide risk assessments in Australia are discussed.
Time to Focus on the Scalp Incision Design for Chronic Subdural Hematoma: Technical Note and Experience
Authors: Xiao Juexian , Liu Yu , Gui Shikai , Wei Feng , Zhou Tong , Lv Shulong , Chen Peng , Zhu Xingen , cheng Zujue 
Published: September 2021

Abstract
Objective: The scalp incision design in surgery for chronic subdural hematoma (CSDH) is important but is given little attention or is neglected by most neurosurgeons currently. Faulty scalp incision design will affect the ease of surgery, wound healing, and patients’ satisfaction. This study introduces the technique and experience used in our center regarding scalp incision with an adjustable question mark-shaped for CSDH procedures.Methods: A retrospective analysis was conducted of the medical records of patients with CSDH, who underwent surgical treatment that incorporated this incision design from September 2017 through December 2020. The features of concern were intraoperative scalp incision extension and postoperative wound healing. Those patients were followed for occurrences of scalp dysfunction, and their satisfaction with this design.Results: Thirty-seven patients were analyzed. For 2 patients, operative procedures were changed and scalp incisions were extended. All patients had good incision healing without complications. The outpatient or telephone follow-up 6 months after surgery revealed that 36 patients were satisfied with the scalp incision design, one patient experienced widening of incision scar. Six patients (5 women and 1 man) reported cosmetic dissatisfaction, and 7 patients (six women and one man) had mild scalp dysfunction, in daily life.Conclusion: The adjustable question mark-shaped incision used for CSDHs is a fluent curve, with a large angle, and allows a flexible extension. It ensures ease of the operative procedure, good wound healing and meeting patients’ aesthetic needs. The protocol is simple, practical, and worthy of reference by neurosurgeons, especially in primary hospitals.
Influence of Control Strategy in Risk Mitigation of Building Damage Due to Earthquake
Authors: Mamat Normaisharah , Othman Mohd Fauzi , Yakub Mohd Fitri Mohd 
Published: September 2021

Abstract
Building structures are prone to damage due to natural disasters, and this challenges structural engineers to design safer and more robust building structures. This study is conducted to prevent these consequences by implementing a control strategy that can enhance a building's stability and reduce the risk of damage. Therefore, to realize the structural integrity of a building, a hybrid control device is equipped with control strategies to enhance robustness. The control strategy proposed in this study is adaptive nonsingular terminal sliding mode control (ANTSMC). ANTSMC is an integrated controller of radial basis function neural network (RBFNN) and nonsingular terminal sliding mode control (NTSMC), which has a fast dynamic response, finite-time convergence, and the ability to enhance the control performance against a considerable uncertainty. The proposed controller is designed based on the sliding surface and the control law. The building with a two-degree-of-freedom (DOF) system is designed in Matlab/Simulink and validated with the experimental work connected to the LMSTest.Lab software. The performance of this controller is compared with those of the terminal sliding mode control (TSMC) and NTSMC in terms of the displacement response, sliding surface, and the probability of damage. The result showed that the proposed controller, ANTSMC can suppress vibrations up to 46%, and its percentage probability of complete damage is 15% from the uncontrolled structure. Thus, these findings are imperative towards increasing the safety level in building structures and occupants, and reducing damage costs in the event of a disaster.
Angina Severity at the Time of Revascularization in Patients With Diabetes Mellitus and Its Association With Long-term Outcomes: A Multicenter Cohort Study.
Authors: Niimi Nozomi , Shoji Satoshi , Sawano Mitsuaki , Ikemura Nobuhiro , Shiraishi Yasuyuki , Inohara Taku , Ueda Ikuko , Fukuda Keiichi , Kohsaka Shun 
Published: September 2021

Abstract
Background: While angina severity is pertinent in determining the management strategy for patients with stable ischemic heart disease (SIHD), its contributing factors and prognostic effect remain unclear, particularly in patients with diabetes mellitus (DM). Methods: From a multicenter percutaneous coronary intervention (PCI) registry, 1,911 consecutive SIHD patients without previous revascularization or heart failure between 2008 and 2015 were analyzed. Angina severity was assessed by the Canadian Cardiovascular Society (CCS) functional classification at the time of PCI. We assessed the contributing factors of CCS III/IV angina. Further, the association between CCS III/IV angina and subsequent occurrence of major adverse cardiac and cerebrovascular events (MACCE: all-cause death, acute coronary syndrome, heart failure, and stroke) within 2 years were analyzed in patients with DM and without DM.Results: A total of 771 SIHD patients (40.3% of all SIHD patients) had DM at the time of revascularization. In the total cohort, 52.4% had CCS I/II, and 13.0% had CCS III/IV angina, with less prevalence of CCS III/IV angina in patients with DM than in those without DM (11.3% vs. 14.2%, P<0.001). In patients with DM, the prevalence of unprotected left main coronary trunk lesions and proximal left anterior descending lesion increased with angina severity. The presence of severe angina at the time of PCI was associated with MACCE in patients with DM (adjusted hazard ratio 1.93; [95% CI 1.01, 3.71]; P=0.047), while no significant difference in those without DM (adjusted hazard ratio 0.82; [95% CI 0.42, 1.59]; P=0.55).Conclusions: In SIHD patients with DM that underwent PCI, severe angina at the time of revascularization was associated with complex coronary anatomies and long-term outcomes. These findings underscore the importance of evaluating angina-related health status while considering revascularization in SIHD patients with DM.
Impact of Vegetation Cover Structure on Birds' Community at Tianfu National Wetland Park in Jiangsu Kunshan, China
Authors: Ajloon Fathielrahaman. H. , Xie Dong , Junxue Shao , RuiTing Zhang , Inayng Aniefiok Ini 
Published: September 2021

Abstract
Vegetation cover has an essential role in wetland habitats in controlling avian populations throughout the world. The vegetation cover structure in grassland systems varies dramatically among seasons on the same sites. Variation in vegetation cover-abundance richness and diversity has been studied through one hundred forty-seven quadrate samples during summer and autumn, 2019, winter, and spring 2020. Avian spe cies richness and diversity were recorded during the same period. Meanwhile, correlation analysis results confirmed that: (1) there was no apparent seasonal difference in the abundance of vegetation cover while avian abundance was statistically different. (2) Plant abundance in summer was positively correlated with the number of avian, while in autumn it was negatively correlated. Plant and avian abundance at the genus level showed a positive correlation while maintaining a negative correlation at the speci es level (p < 0.05). However, during summer and autumn, a strong linear relationship exists between vegetation coverage and avian. The Shannon diversity index and Simpson diversity index have a positive linear relationship between vegetation coverage and a vian families and genera. Therefore, we conclude that vegetation coverage and richness significantly impact avian communities. We suggest further research into the relationship between other biological communities and farming practices in the wetlands.
PH3 and AsH3 Adsorption Through Pristine and Stone-Wales Defected Zinc Oxide Nanosheets: A Density Functional Theory Study
Authors: Heravi Mohammad Reza Poor 
Published: September 2021

Abstract
The adsorption of the XH3 (X = As or P) molecules were explored onto a pure and Stone-wales defected ZnONS (SW ZnONS) through density functional theory computations. As XH3 approaches the pure ZnONS their adsorption releases -3.7 to -7.6 kcal/mol, indicating a physisorption. Also, the electronic properties of the nanosheet do not change significantly. But when AsH3 approaches SW ZnONS, its adsorption releases -23.3 kcal/mol, and electronic analysis showed that the SW ZnONS HOMO/LUMO gap reduces about ~ -27.1% and the electrical conductivity increases significantly. Therefore, the SW ZnONS can generate electrical signals when the AsH3 molecule approaches, being a hopeful sensor. τ value which calculated for the desorption of AsH3 from the surface of the SW ZnONS is 9.5 s. This indicates that the SW ZnONS has the advantage of having a short τ as a sensor for AsH3 detection.
The Clinical Effectiveness and Cost-Effectiveness of Rituximab Versus Natalizumab in Patients With Relapsing Remitting Multiple Sclerosis
Authors: Rezaee Mehdi , Morowvat Mohammad Hossein , Poursadeghfard Maryam , Radgoudarzi Armin , Keshavarz Khosro 
Published: September 2021

Abstract
Introduction: Multiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths of the nerve cells in the brain and spinal cord, which are responsible for communication, are destroyed and cause physical signs and symptoms. According to studies, anti-CD20 monoclonal antibodies have significant results in the treatment of this disease. Thus, the aim of the present study was to determine the effectiveness and cost-effectiveness of Rituximab against Natalizumab in the patients with MS in southern Iran in 2020. Methods: This is an economic evaluation including cost-effectiveness analysis in which the Markov model with a lifetime horizon was used. The study sample consisted of 120 patients randomly selected from among those referred to the MS Association and the Special Diseases Unit of Shiraz University of Medical Sciences. In this study, the costs were collected from a societal perspective, and the outcomes were obtained in the form of Quality Adjusted Life Years (QALY) and the mean recurrence rate. The TreeAge pro 2020 and Excel 2016 software were used for data analysis. Results: The comparative study of Rituximab and Natalizumab showed that the patients receiving Rituximab had lower costs ($ 58307.931 vs. $ 354174.85) and more QALYs (7.77 vs. 7.65). In addition, the incidence of relapse by Rituximab was lower compared to Natalizumab (1.15 vs. 2.57). The probabilistic one-way sensitivity analysis showed the robustness of the results. The scatter plots also showed that Rituximab was more cost-effective for the patients in 100% of the simulations for the threshold of >$ 37,641. Discussion and Conclusion: According to the results of this study, Rituximab had higher cost-utility and cost-effectiveness than Natalizumab. Therefore, it could be a priority for MS patients compared to Natalizumab because it reduced treatment costs and increased effectiveness.
Use of a New off-the-Shelf 3D-Printed Trabecular Titanium Acetabular Cup in Chinese Patients Undergoing Hip Revision Surgery: Short- to Mid-Term Clinical and Radiological Outcomes
Authors: Shang Guangqian , Xiang Shuai , Guo Cuicui , Guo Jianjun , Wang Peng , Wang Yingzhen , Xu Hao 
Published: September 2021

Abstract
Background: Revision total hip arthroplasty (THA) has been a challenge for surgeons. The purpose of this study was to explore the short-to mid-term clinical and radiological outcomes of Chinese patients who underwent revision THA using a new off-the-shelf three-dimensional (3D)-printed trabecular titanium (TT) acetabular cup by comparison with a conventional porous coated titanium acetabular cup, to provide a reference for the recommendation of this prostheses.Methods: A retrospective analysis of 57 patients (57 hips) who received revision THA was performed from January 2016 to June 2019. A total of 23 patients received 3D-printed cups (observation group) and 34 patients received non-3D-printed cups (control group). Clinical scores including Visual Analogue Scale (VAS), Harris Hip Score (HHS) and Short Form 36 (SF-36), upward movement of the hip center of rotation（HCOR）and limb-length discrepancy (LLD), stabilization and bone ingrowth of cups were compared between two groups. The multivariate linear regression was used to determine the factors potentially influencing the HHS score. Postoperative complications in the two groups were also recorded. Results: All 57 patients were routinely followed up. The average follow-up durations in the control and observation groups were 43.57 ± 13.68 (24–65) months and 41.82 ± 11.44 (24–64) months, respectively (p = 0.618). The postoperative clinical scores significantly improved in both groups compared to the preoperative scores (p < 0.05). The VAS score did not significantly differ between the groups at 3 or 12 months postoperatively, or at the last follow-up (p > 0.05). The HHS and SF-36 scores did not significantly differ between the groups at 3 months postoperatively (p > 0.05) but differed at 12 months postoperatively and the last follow-up (p < 0.05). Compared with the control group, the postoperative recovery of HCOR and LLD was better in the observation group (p < 0.05). All cups remained stable, with no loosening throughout the follow-up period. But the observation group had a significantly better rate of bone ingrowth compared to the control group (p = 0.037). Multivariate linear regression analysis showed that different cup types, upward movement of the HCOR, and LLD influenced the HHS score at the last follow-up (p < 0.05). None of the patients exhibited severe postoperative complications.Conclusion: The new off-the-shelf 3D-printed TT acetabular cup demonstrated encouraging short-to mid-term clinical outcomes in Chinese patients. It can effectively relieve pain, improve hip function, provide satisfactory biological fixation and high survival rate. But further follow up is necessary to assess its long-term outcomes.
Discovery of Deccan Inclination Anomaly and its possible geodynamic implications over the Indian Plate
Authors: Sangode S J , Dongre Ashish , Bhagat Amarjeet , Meshram Dhananjay 
Published: September 2021

Abstract
The rapid northward drift of the Indian plate during Deccan volcanism assumes a gradual shallowing of paleomagnetic inclinations in subsequent lava flow formations. A comparison of palaeomagnetic data produced during the last six decades reveals an inclination anomaly during Chron C29r (66.398–65.688 Ma) along with brief clockwise-counter-clockwise rotations during and after the main phase Deccan eruption. This interval temporally coincides with i) an accelerated Indian ocean spreading rates, ii) brief incursion of an inland ‘seaway’ and iii) a major drop in the sea level at the southern tip of the Indian Peninsula. Furthermore, the restoration of tilt later during C29n agrees with the withdrawal of the inland seaway and the development of a regional southward dip of the Deccan lava flow formations. Here, we produce an evolutionary model to postulate the interaction of the Réunion plume with the Indian lithospheric plate with coincident geological evidences demanding further exploration.
Experiences of Patients With Chronic Obstructive Pulmonary Disease receiving Integrated Telehealth Nursing Services During COVID-19 Lockdown
Authors: Arnaert Antonia , Ahmad Hamza , Mohamed Shameera N. , Hudson Emilie , Craciunas Stephanie , Girard Alice , Debe Zoumanan , Dantica Joséphine Lemy , Denoncourt Candice , Côté-Leblanc Geneviève 
Published: September 2021

Abstract
Objective: Even though telemonitoring existed prior to COVID-19, the need was accelerated for patients with COPD due to the limited medical consultations and the anxiety for being infected. To our knowledge, no qualitative study has explored the experiences of COPD patients and the potential benefits of receiving integrated telehealth nursing services during the lockdown. Methods: Ten participants were interviewed after receiving telehealth nursing services for 3 months; data was analyzed thematically. Results: Irrespective of COPD severity, all participants expressed that the existing fragmented follow-up care was intensified during COVID. The telenursing services provided them with the comfort and reassurance that a clinician is available for support, advice, and care during the times of isolation. Despite diverse opinions regarding the respiratory-related questions for follow-up, all were enthusiastic about the use of the oximeter in their daily lives. None perceived sharing data as an issue, instead they encouraged the exchange across levels of care. Conclusion: Despite an appreciation for the service, it is imperative for sustainability reasons that standardized protocols are developed to balance patient preferences in terms of response frequency and the clinical data needed for a telenurse to provide appropriate interventions.
The GC-TOF/MS-based Metabolomic Analysis Reveals Altered Metabolic Profiles in Nitrogen-Deficient Leaves and Roots of Tea Plants (Camellia sinensis L.)
Authors: Lin Zheng-He , Chen Chang-Song , Zhong Qiu-Sheng , Ruan Qi-Chun , Chen Zhi-Hui , You Xiao-Mei , Shan Rui-Yang , Li Xin-Lei 
Published: September 2021

Abstract
Background: Nitrogen (N) fertilizer is commonly considered as one of the most omportant limiting factors in the agricultural production. As a result, modern tea production, a large amount of N fertilizer is used to improve the yield. Unfortunately, the large amount of N fertilizer input has led to increased plant nitrogen-tolerance and decreased amplitude of yield improvement, which results in significant N loss, energy waste and environment pollution.However, the effects of N-deficiency on the metabolic profiles of leaves and roots are not well understood.Results: In the study, seedlings of Camellia sinensis (L.) O. Kuntze cv. Chunlv 2 were treated with 3 mM NH4NO3（as Control）or without NH4NO3（as N-deficiency）for 4 months by sandy culture. The results suggested the N-deficiency induced tea leaf chlorosis, impaired biomass accumulation, decreased the leaf chlorophyll content and N absorption compared to Control. The untargeted metabolomics based on GC-TOF/MS approach revealed discrimination of the metabolic profiles between N-deficient tea leaves and roots. The identification and classification of the altered metabolites indicated the N deficiency upregulated the relative abundances of most phenylpropanoids, organic acids while downregulated the relative abundances of most amino acids in the tea leaves. Differentially, N-deficiency induced the accumulation of most carbohydrates, organic acids and amino acids in the tea roots. The potential biomarkers screened in the N-deficient leaves compared to Control reflected the N deficiency reduced the tea quality. Unlike the N-deficient leaves, the potential biomarkers in the N-deficient roots implied an improved stress response. Conclusions:The results demonstrated the N deficiency had different effects on the primary and secondary metabolic alteration of tea leaves and roots. The findings of the study will facilitate a comprehensive understanding of the N-deficient tea plants and provide a valuable reference for the optimized N nutrient management in the tea plantations.