bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the HBV model for the future projections of water levels using dynamically downscaled global climate model data
Authors: Pervin Lia , Gan Thian Yew , Scheepers Hester , Islam Md Saiful 
Published: March 2021

Abstract
The Hydrologiska Byråns Vattenbalansavdelning (HBV) model was used to project the future water levels of the Mackenzie River at selected stations. The Weather Research and Forecasting (WRF) model was utilized to dynamically downscale the Global Climate Model data. The calibrated and validated HBV model was run with the WRF downscaled CanESM2 data and with the PCIC data for the historical (1979–2005) period, and then compared with the observed flow data at the Fort Simpson station and the Arctic Red River station. The simulated streamflow showed a good correlation with the observed streamflow (R2 value was around 0.85). The HBV model was then forced with the bias-corrected WRF downscaled daily rainfall and temperature data driven by the CanESM2 RCP 4.5 and RCP 8.5 climate scenarios to simulate the future streamflow for the 2041–2070 period. Rating curves were used to convert streamflow to water levels. At the Fort Simpson station, mean flow was projected to decrease by about 5% under both RCP 4.5 and RCP 8.5 scenarios, whereas the peak flow was likely to reduce by about 12 and 9% for RCP 4.5 and RCP 8.5 scenarios, respectively, in the 2050s. The projected lower water levels could affect the navigability and the northern ferry operations of the Mackenzie River.
The Use of L-Glucose in Cancer Diagnosis: Results from In Vitro and In Vivo Studies
Authors: Anastasiou Ioanna A. , Eleftheriadou Ioanna , Tentolouris Anastasios , Mourouzis Iordanis , Pantos Constantinos , Tentolouris Nikolaos 
Published: March 2021

Background:
Cancer cells are characterized by metabolic heterogeneity. Although
many research groups make efforts to analyze this heterogeneity, little attention
has been paid to cancer cells utilizing otherwise unusable substrates as fuel for tumor development.
Of the two stereoisomers of glucose, D-glucose but not L-glucose, the mirror
image isomer of D-glucose is abundantly found in nature. D-glucose is the human body's
key source of energy through aerobic respiration. However, data from in vitro and in vivo
studies examining the ability of cancer cells to take up L-glucose are scarce.

Objectives:
The present mini-review aims to present current literature data on the role of
L-glucose in cancer diagnosis based on in vitro and in vivo studies.

Methods:
The MEDLINE, EMBASE, and the Cochrane Library with restrictions to articles
in English language databases were searched to retrieve available data.

Results:
There are limited data in the literature regarding in vitro and in vivo studies that
examined the ability of cancer cells to take up L-glucose. Research work so far has
shown that that the binding of a fluorescent detector to an L-glucose molecule produced
a fluorescent probe that was specifically taken up by malignant cancer cells, thus providing
a unique method for their detection.

Conclusion:
Given that L-glucose is taken up by cancer cells, L-glucose fluorescent
probes can be a useful tool for visualization and characterization of cancer cells. More research
on the potential biologic effects of L-glucose in cancer is necessary.
The Stress of the COVID-19 Pandemic: Beyond the Data
Authors: Salim Samina 
Published: March 2021

Background:
The year 2020 will go down in modern history as the one ravaged by a
pandemic, the one which humbled the entire world. From the richest and most advanced nations to
the poorest and least developed ones, it exposed all of our vulnerabilities. The loss of life, health
disparities and economic adversities, aggravated by political and ideological tensions, added multiple
layers of stress and anxieties to an already stressed American society.

Methods:
The educational institutions in the United States from the central to the local units demonstrated
coherence in leadership, guided with flexibility and compassion, which paved the way for
smooth operations. However, anxiety among students and faculty of university and college campuses
is undeniable. In-person instruction was halted. Research labs and offices were locked down
or operating with limited personnel. Thus, the challenges to have timely instruction and to move the
research enterprise forward have been enormous. Provided here is a perspective based on a literature
search using PubMed and Google with search words “COVID-19, stress, college students”,
“COVID-19, stress, US graduate students”, and “COVID-19, stress, postdoc researchers”.

Results:
This article is an opinion piece, part personal and part peer experiences. It is presented in
light of studies suggesting that the COVID-19 pandemic has imposed significant mental stress and
anxiety upon students and faculty members within the academy.

Conclusion:
Loss of face-to-face interactions as a result of virtual instruction, lack of in-person
mentoring, and loss of research productivity has taken its toll on the mental health and well-
being of the academic community. Despite the challenges of the pandemic, the ingenuity of the human spirit has innovated solutions to catch up on research productivity and to pursue academic excellence.
Neural Basis of Dental Pulp Stem Cells and its Potential Application in
Parkinson’s Disease
Authors: Sharma Yogita , Shobha K , Sundeep Mata , Pinnelli Venkata Bharatkumar , Parveen Shagufta , Dhanushkodi Anandh 
Published: March 2021

:
Parkinson’s Disease (PD) is the second most common neurodegenerative disease after
Alzheimer’s disease. Though significant insights into the molecular-biochemical-cellular-behavioral
basis of PD have been understood, there is no appreciable treatment available till date. Current
therapies provide symptomatic relief without any influence on the progression of the disease. Stem
cell therapy has been vigorously explored to treat PD. In this comprehensive review, we analyze
various stem cell candidates for treating PD and discuss the possible mechanisms. We advocate the
advantage of using neural crest originated Dental Pulp Stem Cells (DPSC) due to their predisposition
towards neural differentiation and their potential to regenerate neurons far better than commonly
used bone marrow derived mesenchymal stem cells (BM-MSCs). Eventually, we highlight the
current challenges in the field and the strategies, which may be used for overcoming the impediments.
COVID-19 and Orthodontics: An Approach for Monitoring Patients at Home
Authors: Bianco Antonio , Dalessandri Domenico , Oliva Bruno , Tonni Ingrid , Isola Gaetano , Visconti Luca , Paganelli Corrado , Bonetti Stefano 
Published: March 2021

Aim:
The aim of this study was to test an experimental approach involving the remote monitoring of orthodontic patients through the use of their smartphones.

Background:
Due to the COVID-19 emergency, dental offices were asked to stop elective treatments; suddenly orthodontic patients found themselves isolated at home, without the possibility of monitoring by their orthodontists. The use of telemonitoring via smartphones can be a quick way to recover the orthodontist-patient relationship, monitor and continue the treatment.

Objective:
The purpose of this study was to propose an innovative, simple and reliable approach for the remote management of orthodontic patients.

Methods:
137 patients were contacted verbally by phone and via WhatsApp®; they were asked to send a set of photographs taken with their smartphone. They were asked to complete a questionnaire to evaluate the effectiveness of the approach. Descriptive statistics (frequency with percent) of questionnaire results and the presence of procedural errors while taking pictures were calculated. Correlations between different questionnaire answers were analyzed with the Chi-Square test. Variables with p < 0:05 were declared as significant.

Results:
The majority of patients considered that this approach was positive and they did not feel abandoned. Difficulties emerged from a technical point of view, that is, in terms of photoshoot, and part of the patients expressed perplexity regarding the fact that telemonitoring can replace completely an outpatient visit.

Conclusion:
The use of telemonitoring managed to recreate a relationship with the orthodontist, especially in emergency periods.
Telemedicine for a Multidisciplinary Assessment of Orofacial Pain in a Patient Affected by Eagle’s Syndrome: A Clinical Case Report
Authors: Quinzi Vincenzo , Paskay Licia Coceani , Manenti Rebecca Jewel , Giancaspro Silvia , Marzo Giuseppe , Saccomanno Sabina 
Published: March 2021

Background:
Orofacial pain has a broad range of origins and a multidisciplinary approach occupies a relevant role.

Objective:
The aim of this study was to review the literature regarding the evolution of telemedicine and orofacial pain related to a case report of a patient affected by Eagle's syndrome.

Materials and Methods:
Two authors (RJM and SG) independently reviewed the literature up to March 2020. A case report was developed by including the interdisciplinary assessment and initial treatment of orofacial pain in a 38-year-old female patient affected by Eagle’s syndrome. The patient was interviewed by two different specialists (from Rome, Italy and Los Angeles, California) through an online meeting platform in order to evaluate her complex situation, demonstrating the possibilities that telemedicine offered during the COVID-19 pandemic.

Conclusion:
An interdisciplinary approach can be performed for future follow ups on patients as various advantages were found by the patient and by the clinicians themselves.
An 11-Item Measure of User- and Human-Centered Design for Personal Health Tools (UCD-11): Development and Validation
Authors: Witteman Holly O , Vaisson Gratianne , Provencher Thierry , Chipenda Dansokho Selma , Colquhoun Heather , Dugas Michele , Fagerlin Angela , Giguere Anik MC , Haslett Lynne , Hoffman Aubri , Ivers Noah M , Légaré France , Trottier Marie-Eve , Stacey Dawn , Volk Robert J , Renaud Jean-Sébastien 
Published: March 2021

Background
Researchers developing personal health tools employ a range of approaches to involve prospective users in design and development.

Objective
The aim of this paper was to develop a validated measure of the human- or user-centeredness of design and development processes for personal health tools.

Methods
We conducted a psychometric analysis of data from a previous systematic review of the design and development processes of 348 personal health tools. Using a conceptual framework of user-centered design, our team of patients, caregivers, health professionals, tool developers, and researchers analyzed how specific practices in tool design and development might be combined and used as a measure. We prioritized variables according to their importance within the conceptual framework and validated the resultant measure using principal component analysis with Varimax rotation, classical item analysis, and confirmatory factor analysis.

Results
We retained 11 items in a 3-factor structure explaining 68% of the variance in the data. The Cronbach alpha was .72. Confirmatory factor analysis supported our hypothesis of a latent construct of user-centeredness. Items were whether or not: (1) patient, family, caregiver, or surrogate users were involved in the steps that help tool developers understand users or (2) develop a prototype, (3) asked their opinions, (4) observed using the tool or (5) involved in steps intended to evaluate the tool, (6) the process had 3 or more iterative cycles, (7) changes between cycles were explicitly reported, (8) health professionals were asked their opinion and (9) consulted before the first prototype was developed or (10) between initial and final prototypes, and (11) a panel of other experts was involved.

Conclusions
The User-Centered Design 11-item measure (UCD-11) may be used to quantitatively document the user/human-centeredness of design and development processes of patient-centered tools. By building an evidence base about such processes, we can help ensure that tools are adapted to people who will use them, rather than requiring people to adapt to tools.
Brief Interventions via Electronic Health Record Messaging for Population-Based Suicide Prevention: Mixed Methods Pilot Study
Authors: Whiteside Ursula , Richards Julie , Simon Gregory E 
Published: March 2021

BackgroundNew opportunities to create and evaluate population-based selective prevention programs for suicidal behavior are emerging in health care settings. Standard depression severity measures recorded in electronic medical records (EMRs) can be used to identify patients at risk for suicide and suicide attempt, and promising interventions for reducing the risk of suicide attempt in at-risk populations can be adapted for web-based delivery in health care.ObjectiveThis study aims to evaluate a pilot of a psychoeducational program, focused on developing emotion regulation techniques via a web-based dialectical behavior therapy (DBT) skills site, including four DBT skills, and supported by secure message coaching, including elements of caring messages.MethodsPatients were eligible based on the EMR-documented responses to the Patient Health Questionnaire indicating suicidal thoughts. We measured feasibility via the proportion of invitees who opened program invitations, visited the web-based consent form page, and consented; acceptability via qualitative feedback from participants about the DBT program; and engagement via the proportion of invitees who began DBT skills as well as the number of website visits for DBT skills and the degree of site engagement.ResultsA total of 60 patients were invited to participate. Overall, 93% (56/60) of the patients opened the invitation and 43% (26/60) consented to participate. DBT skills website users visited the home page on an average of 5.3 times (SD 6.0). Procedures resulted in no complaints and some participant feedback emphasizing the usefulness of DBT skills.ConclusionsThis study supports the potential of using responses to patient health questionnaires in EMRs to identify a high-risk population and offer key elements of caring messages and DBT adapted for a low-intensity intervention. A randomized trial evaluating the effectiveness of this program is now underway (ClinicalTrials.gov: NCT02326883).
A Modular Mobile Health App for Personalized Rehabilitation Throughout the Breast Cancer Care Continuum: Development Study
Authors: Lim Ji Young , Kim Jong Kwang , Kim Yoon , Ahn So-Yeon , Yu Jonghan , Hwang Ji Hye 
Published: March 2021

Background
Although many mobile health (mHealth) apps have evolved as support tools for self-management of breast cancer, limited studies have developed a comprehensive app and described the algorithms for personalized rehabilitation throughout the breast cancer care continuum.

Objective
This study aimed to develop a comprehensive mobile app and to describe an algorithm that adjusts personalized content to facilitate self-management throughout the breast cancer care continuum.

Methods
The development process of the modular mHealth app included the following 4 steps: (1) organizing expert teams, (2) defining evidence-based fundamental content and modules, (3) classifying user information for algorithms to personalize the content, and (4) creating the app platform and connectivity to digital health care devices.

Results
We developed a modular mHealth app service, which took 18 months, including a review of related literature and guidelines and the development of the app and connectivity to digital health care devices. A total of 11 functionalities were defined in the app with weekly analysis. The user information classification was formulated for personalized rehabilitation according to 5 key criteria: general user information, breast operation type, lymph node surgery type, chemotherapy and hormonal therapy use, and change in treatment after surgery. The main modules for personalized content included a self-monitoring screen, personalized health information, personalized exercise, and diet management.

Conclusions
The strength of this study was the development of a comprehensive mHealth app and algorithms to adjust content based on user medical information for personalized rehabilitation during the breast cancer care continuum.
Normes endogènes et contre-normes dans les ‘anglais du monde’ Modèles d’analyse et terrains de la modernité avancée
Authors: Forlot Gilles 
Published: March 2021

Cet article fournit une vue d’ensemble des divers modèles et théories entourant les enjeux de normes dans les ‘anglais du monde’, en particulier dans les sociétés postcoloniales du cercle extérieur. Il est défendu que le défi de comprendre le développement de l’anglais dans le monde actuel requière des perspectives suffisamment dynamiques pour prendre en compte une variété de phénomènes aux prises avec les sociétés, tels que la migration, la circulation contemporaine des biens et des personnes, les mobilités et interactions virtuelles, la ‘commodification’ des langues, c’est-à-dire, en bref, toutes sortes de phénomènes produits par et dans la modernité avancée. Il s’agit donc de déplacer les analyses de modèles statiques où les langues et les normes sont vues comme des objets homogènes vers des modèles dynamiques où les pratiques linguistiques et culturelles sont intrinsèquement liées aux pratiques sociales. La deuxième partie de l’article examine plus spécifiquement les questions et débats sur l’émergence de normes linguistiques dans une ville et un pays hautement mondialisé en Asie : Singapour.
Interações entre ficção e realidade: House of Cards e o mundo real
Authors: Casellato Gozzi Giancarlo 
Published: March 2021

Este artigo pretende investigar as relações entre a série televisiva House of Cards (Beau Willimon, Netflix, 2013-2018) e o "mundo real" do qual comenta e no qual participa, analisando tanto como elementos extradiegéticos são trazidos para dentro do mundo ficcional, quanto como a série é apropriada pelo seu público para comentar sobre sua própria conjuntura.
ÁGNES HRANITZKY - QUE LUGAR ELA OCUPA NO CINEMA HÚNGARO?
Authors: Mello Lidia A R S 
Published: March 2021

Este é o primeiro texto existente sobre a editora de filmes húngara, Ágnes Hranitzky (1945-), e montadora dos filmes de Béla Tarr. Discorro sobre sua carreira no cinema húngaro, com ênfase em sua parceria nos filmes dirigidos pelo cineasta Béla Tarr. Conto como ela inicia sua formação e sua prática no meio cinematográfico nos anos 60 na Hungria, explicitando as dificuldades encontradas, até chegar no findar de sua carreira em 2011. Ágnes ingressou na montagem de filmes numa época em que só havia homens nesta área e sofreu muito por isso. Ela deu importante contribuição para o cinema húngaro no Séc. XX e XXI.
Feasibility of Implementing a Pediatric Diabetes Clinic via Telehealth
Authors: Pierce Jessica S. , Gurnurkar Shilpa , Vyas Neha , Carakushansky Maura , Owens Lindsay , Patton Susana R. 
Published: March 2021

OBJECTIVE
In response to the coronavirus disease 2019 (COVID-19) pandemic and social distancing guidelines, our pediatric diabetes team rapidly changed the format of conducting diabetes clinic from in person to telehealth. We compared the actual number and rate of completed, canceled, and no-show visits between an 8-week period in 2019, when we exclusively conducted visits in person and the same 8-week period in 2020, during the COVID-19 quarantine, when we exclusively conducted visits via telehealth.

METHODS
We used electronic health record data for all patients, as well as Dexcom continuous glucose monitoring data collected for a subset of youths during the COVID-19 quarantine and the immediate pre–COVID-19 period.

RESULTS
Although there was a difference in the absolute number of in-person versus telehealth visits canceled during these two time periods, there was no difference in the rates of completed, canceled, and no-show visits completed in person or via telehealth. This finding suggests that, despite a rapid shift to a completely new health care delivery model, our providers completed a similar rate of patient care via telehealth during the COVID-19 quarantine and that telehealth may be a feasible method for providing diabetes care. However, our results also suggested that youths’ glucose management was less optimal during the quarantine period.

CONCLUSION
COVID-19 presented an opportunity to adopt and test the feasibility of using a telehealth delivery model for routine diabetes care. Yet, to make telehealth a viable treatment delivery alternative will likely involve the uptake of new clinic procedures, investment in institutional infrastructure, and team-based flexibility.
Longe daqui, aqui mesmo
Authors: Lima Silva Luciana 
Published: March 2021

Ao longo das décadas, algumas pensadoras de origem latino-americana se posicionaram como vozes potentes de um pensamento favorável a uma real emancipação feminina, recebendo críticas muitas vezes mordazes às perspectivas que evidenciaram, desalinhadas aos sistemas de valores da sociedade tanto um século atrás quanto agora, em que as pautas conservadoras reassumiram o topo do poder em diferentes países e governos. Observando esse fenômeno, este trabalho se propõe a destacar algumas das proposições da brasileira Ercília Nogueira Cobra e da chilena Lina Meruane relacionadas a questões feministas, para debatê-las à luz da época em que essas escritoras estão inseridas. Para isso, serão analisadas as obras Virgindade anti-higiênica (1924), de Ercília Nogueira Cobra, e Contra os filhos (2018), de Lina Meruane.
Palavras-chave: feminismo; mulheres; literatura brasileira; literatura latino-americana; Américas.
Pedagogia queer em tempos de “ideologia de gênero” e “kit gay”
Authors: Ruiz Melissa Salinas 
Published: March 2021

Na sociedade brasileira contemporânea atuam grupos sociais contrários à expansão dos direitos sexuais e do debate sobre gênero e sexualidade. Tais grupos denominam essas discussões pejorativamente de “ideologia de gênero”. Esse fenómeno também alcança o sistema educativo, gerando críticas a professores e a instituições escolares que discutam aspectos de diversidade. Exemplo disso é o furor gerado pela crença no “kit gay”, o qual permite notar quão problemático é dialogar sobre o queer nas escolas brasileiras. Ao se pretender uma instituição onde impera a neutralidade de gênero, a escola acaba reproduzindo as rígidas normativas sexuais e de gênero. Torna-se necessário que esta se posicione de maneira contrária à cisnormatividade, uma vez que o ambiente escolar acaba segregando os corpos e sexualidades considerados dissidentes. Apesar das dificuldades, considera-se que a pedagogia queer é uma maneira relevante de tornar o sistema educativo mais capaz de receber a população LGBTQI. Portanto, o objetivo deste trabalho é apresentar algumas possibilidades para implementar uma pedagogia queer nas escolas brasileiras. Desse modo, explica o conceito de pedagogia queer, discute o fenómeno do “kit gay”, relacionando-o à crença na ‘ideologia de gênero” e apresenta estratégias para levar a cabo uma proposta pedagógica queer. Assim, espera-se minimizar o potencial problemático de discutir sobre gênero e sexualidade nas instituições escolares.
Palavras-Chave: Pedagogia queer; Gênero; Escola; Sociedade;
Hamlet - Character Deconstruction
Authors: Nanthitha K. 
Published: March 2021

This paper focuses on deconstructing the prejudiced and conventional notions on the prince Hamlet. In this paper the difficult circumstances of Hamlet will be analysed and factors responsible for the tragedy are discussed. The negative notions on Hamlet will be deconstructed and he will be viewed as a piteous young boy in the end. This paper will concentrate on the unnoticed aspects of the play. This play Hamlet can be interpreted in many ways but Deconstruction will be the best way to analyse the play and the character of Hamlet because it helps in viewing the character in multi-dimensions. It also speaks about how emotions has to be handled, how the parenting plays the most important role in the character development of a child. This paper will mirror out how an individual’s life is stained and destroyed by the lack of proper care and guidance.