bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific features of amoxicillin‐associated Drug Reaction with Eosinophilia and Systemic Symptoms syndrome: a nationwide study
Authors: Largeau B. , Agier M.‐S. , Beau‐Salinas F. , Pariente A. , Maruani A. , Vial T. , Jonville‐Béra A.‐P. 
Published: August 2021

AbstractBackgroundGrowing evidence indicates that amoxicillin induces herpesvirus replication in vitro. As these play a central pathophysiological role in Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS), amoxicillin could present with specific DRESS features.ObjectiveTo characterize the onset patterns of amoxicillin‐associated DRESS.MethodsAll cases of DRESS (Kardaun score ≥4) involving amoxicillin and reported in the French Pharmacovigilance Database between January 1, 2004 and November 30, 2019 were included. Onset circumstances for these cases were categorized considering the onset delay from amoxicillin initiation, and the presence of concomitant medications with a compatible time to onset.ResultsA total of 146 probable cases or definite cases of DRESS were included. Three onset circumstances were identified: (i) ‘amoxicillin clear culprit’ where amoxicillin was the sole suspect drug or when concomitant drugs of compatible time to onset were not reported to cause DRESS (n = 62); (ii) ‘amoxicillin possible culprit’ in the presence of other potentially culprit drugs in addition to amoxicillin (n = 44) and (iii) ‘flare’ where amoxicillin, used after DRESS onset, induced flare‐up reactions (n = 40). The median time to onset was 5 days (IQR 2–11) in ‘clear culprit’, and 18 days (IQR 7–26) in ‘possible culprit’ cases. In ‘flare’ cases, the median latency between amoxicillin initiation and flare‐up reactions was 3 days (IQR 2–5).ConclusionsAmoxicillin can induce DRESS with a specific early onset and exacerbate DRESS from another drug.
Colour pattern variation forms local background matching camouflage in a leaf‐mimicking toad
Authors: Barnett James B. , Michalis Constantine , Scott‐Samuel Nicholas E. , Cuthill Innes C. 
Published: August 2021

AbstractOptimal camouflage can, in principle, be relatively easily achieved in simple, homogeneous, environments where backgrounds always have the same colour, brightness and patterning. Natural environments are, however, rarely homogenous, and species often find themselves viewed against varied backgrounds where the task of concealment is more challenging. One result of variable backgrounds is the evolution of intraspecific phenotypic variation which may either begeneralized, with multiple similarly cryptic patterns, orspecialized, with each discrete colour form maximizing concealment against a single component of the background. We investigated the role of phenotypic variation in a highly variable population of the Neotropical toadRhinella margaritiferausing visual modelling and a computer‐based detection task. We found that phenotypic variation was not divided into discrete colour morphs, and all toads were well camouflaged against the forest floor. However, although the whole population may appear to consist of random samples from the background, the toads were a particularly close match to the leaf litter, suggesting that they masquerade as dead leaves, which are themselves variable. Furthermore, rather than each colour form being equally effective against a single background, each toad was specialized towards its own particular local surroundings, as suggested by a specialist strategy. Taken together, these data highlight the importance of background matching to a nominally masquerading species, as well as how habitat heterogeneity at multiple spatial scales may affect the evolution of camouflage and phenotypic variation.
Biochemically assisted rice whitening for improving head rice yield
Authors: Schefer Larissa , Conde‐Petit Béatrice , Müller Nadina 
Published: August 2021

AbstractThe maximum attainable head rice yield in conventional long grain rice milling is approximately 64%, with around 15% being lost as a result of broken rice kernels. The primary objective of this project was, therefore, to improve the milling yield. To achieve this goal, biochemically assisted whitening processes involving the application of different aqueous solutions were evaluated. Head rice yield was increased for all tested liquids (3.3–3.8% depending on liquid) for Gladio‐type brown rice treated with 0.5% liquid prior to whitening to 40 Kett using a lab‐scale horizontal friction‐type McGill whitener. However, the moistening led to increased caking in the McGill milling chamber. In comparative trials, the use of moistening solutions containing enzymes, sorbit, or sodium chloride instead of pure water delivered a slightly, but nevertheless, significantly higher degree of whiteness directly after milling while it did not result in a significant reduction in the number of broken kernels. Since average head rice yield has a 43% higher commercial value than broken kernels, the 3.6% improvement in milling yield achieved by adding 0.5% water would result in an estimated increase in profit for a 7.5 t/h rice mill of 0.83%.Practical applicationsRice as a global staple food bears a critical role in human nutrition. At the same time, the quality of milled rice is a key buying and price criterion in rice‐consuming countries. One key quality criterion is the number of brokens in rice. Hence, it is critical for rice millers to minimize the degree of broken kernels. Biochemically assisted rice whitening for improving head rice yield is a combined biochemical and physical method to facilitate bran removal from brown rice. The main aim of the present study was to investigate the effect of biochemically assisted rice whitening on the number of brokens and to assess potential technological challenges resulting from the liquid addition.
Efficacy of sonication–microfiltration hybrid process for the production of clarified bitter gourd extracts
Authors: Chakraborty Sushma , Uppaluri Ramagopal , Das Chandan 
Published: August 2021

AbstractIn this article, the efficacy of hybrid ultrasound‐assisted extraction (UAE) and microfiltration (MF) process toward effective processing of bitter gourd extract has been addressed. The extracts obtained from the UAE process have been used as the feed for a microfiltration process using low‐cost ceramic membranes of variant morphologies (i.e., 1 [CM1], 0.75 [CM2], and 0.45 μm [CM3] membranes). Three different pressure differentials (103.4, 137.9, and 172.4 kPa) were considered to evaluate upon the optimality of applied pressure. Flux decline profiles, flux decay coefficients (FDC), and fouling characteristics of the ceramic membranes were considered to gain useful insights with respect to the pertinent morphological changes. Based on the investigations carried out, the hybrid process is inferred to considerably reduce membrane fouling (lower FDC). The membrane fouling was analyzed to be due to cake filtration followed by intermediate pore blocking. The nutrient characteristics indicated considerable protein rejection and retention of 46.47%, very low color (0.049 A), and high clarity (98.17%) for the optimal process conditions of 137.9 kPa applied pressure and CM2 membrane. The hybrid UAE–MF process proved to be a good alternative to the conventional processes and can be inferred to be at par with other nonthermal juice processing technologies.Practical applicationsContemporary lifestyle and habitat necessitate upon the production and utilization of nutritionally rich vegetable aqueous extracts with better shelf life and lower processing costs. The reported findings of this article can potentially influence the conventional thoughts associated to the deployment of low‐cost food processing technologies for the mentioned horticultural extract product system. Given that the article indicates cost‐effective production of bitter gourd juice extract with anticipated shelf life, the mentioned product can be considered as a low‐cost food supplement toward the yield of healthy and natural food products.
Novel use of poly‐L‐lactic acid filler for the treatment of facial cutaneous atrophy in patients with connective tissue disease
Authors: Pamatmat Jarod John , Gonzalez Cristian D. , Euwer Rebecca , Summers Erika , Smart David , Goff Heather W. 
Published: August 2021

AbstractBackgroundPatients with connective tissue disease (CTD) often suffer from facial cutaneous defects and resultant facial asymmetry. Unfortunately, these issues have been known to be difficult‐to‐treat, and concern exists regarding the use of cosmetic procedures in this patient population due to the theoretical risk of disease flare‐up or reactivation. Injectable poly‐L‐lactic acid (PLLA) is one type of filler that has been used to treat skin atrophy in patients with morphea and lupus erythematous panniculitis. However, overall, there is a dearth in literature regarding the safety and efficacy of PLLA filler in patients with CTDs.AimsThis case series intends to evaluate the safety and efficacy of PLLA filler in treating facial atrophy in patients with CTDs.Patients/MethodsThree patients underwent various treatment courses involving the use of PLLA filler to treat facial atrophy.ResultsTwo patients demonstrated significant improvement in facial atrophy following their treatment course. No patient experienced reactivation or exacerbation of their CTD following PLLA injection.ConclusionPLLA filler appears to have good viability as a safe and potentially effective treatment for facial atrophy in patients with CTDs.
Application of the national early warning score (NEWS) in patients with acute aortic dissection: A case–control study
Authors: Liu Yuwen , Li Qingyin , Zhang Yanjuan , Zhao Rui , Pang Ran , Ren Hua 
Published: August 2021

AbstractBackgroundThe vital‐sign monitoring strategy of patients with acute aortic dissection in the emergency department is mainly based on traditional experience. This study attempts to explore the significance of the national early warning score (NEWS) in monitoring the condition of patients with acute aortic dissection during emergency observation and to provide evidence for emergency nurses in optimal and scientific monitoring of patients.MethodsThe case–control method was used to continuously enrol patients with acute aortic dissection who had been in the emergency department; the STROBE checklist was used in this process. Based on patients’ clinical deterioration, they were divided into two groups: clinical deterioration and non‐clinical deterioration. The NEWS at each time point was compared by independent‐samples t‐test, and the predictive power of NEWS was evaluated according to the area under the receiver operating characteristic curve.ResultsA total of 290 patients with acute aortic dissection were included: 46 patients showed clinical deterioration and 244 did not. There were significant differences in the NEW scores of the two groups at admission time and at 12, 8, 4 and 0.5 h before clinical deterioration. The NEW scores of the clinical deterioration group showed an upward trend, while the non‐clinical deterioration group showed a relatively stable trend. The NEWS can be used to predict the occurrence of clinical deterioration earlier at 4 h before clinical deterioration. Simultaneously, the patient's respiration rate and SpO2 had better predictive performance than other vital signs.ConclusionThe NEWS can be used to triage patients with acute aortic dissection admitted to the emergency department. Continuous use of the NEWS for monitoring can play a vital role in early warning of clinical deterioration in patients with acute aortic dissection. In clinical care, attention should also be paid when patients with acute aortic dissection have abnormal respiration rate and SpO2.
A conceptual model of oro‐facial health with an emphasis on function
Authors: Schimmel Martin , Aarab Ghizlane , Baad‐Hansen Lene , Lobbezoo Frank , Svensson Peter 
Published: August 2021

AbstractThe individual inclination to lead an autonomous life until death is associated with requirements that may be of physiological, psychosocial and environmental nature. We aim to describe a conceptual oro‐facial health model with an emphasis on oro‐facial function, taking the domains of quality of life and patient‐centred values into account. In the context of oro‐facial function, the requirements of life are met when the oro‐facial system is in a fit state. ‘Fitness of the oro‐facial system, that is oro‐facial health, is a state that is characterised by an absence of, or positive coping with physical disease, mental disease, pain and negative environmental and social factors. It will allow natural oro‐facial functions such as sensing, tasting, touching, biting, chewing, swallowing, speaking, yawning, kissing and facial expression’. In the presented conceptual model of oro‐facial health, it is postulated that each individual has present and future potentials related to biological prerequisites and resources that are developed by an individual through the course of life. These potentials form the oro‐facial functional capacity. When the individual potentials together do not meet the requirements of life anymore, dysfunction and disease result. The oro‐facial system is subject to physiological ageing processes, which will inevitably lead to a decrease in the oro‐facial functional capacity. Furthermore, comorbid medical conditions might hamper oro‐facial function and, alongside with the ageing process, may lead to a state of oral hypofunction. Currently, there is a lack of widespread, validated, easy‐to‐use instruments that help to distinguish between states of oro‐facial fitness as opposed to oral hypofunction. Clearly, research is needed to establish adequate, validated instruments alongside with functional rehabilitation procedures.
Modeling Descriptive and Deontic Cognition as Two Modes of Relation Between Mind and World
Authors: Stovall Preston 
Published: August 2021

AbstractI use a distinction betweensingle‐mindedandindifferentchoice attitudes, modeled across maximally determinate plans of action, as a basis for interpreting deontic claims – about what ought, ought not, and may be done – as expressing a mode of relation between mind and world that gives voice to the exercise of practical rationality. At the same time, I use maximally determinate possible worlds to model descriptive claims in order to understand them as involving a mode of relation between mind and world that manifests our theoretical rationality. The result is of interest to both linguists looking for a formal treatment of deontic modality that captures the role prescriptive mental states play in our lives, and philosophers interested in substantive questions about action‐guiding and representational mental states as exercises of practical and theoretical rationality.
Cost‐effectiveness analyses of augmented cognitive behavioral therapy for pharmacotherapy‐resistant depression at secondary mental health care settings
Authors: Sado Mitsuhiro , Koreki Akihiro , Ninomiya Akira , Kurata Chika , Mitsuda Dai , Sato Yasunori , Kikuchi Toshiaki , Fujisawa Daisuke , Ono Yutaka , Mimura Masaru , Nakagawa Atsuo 
Published: August 2021

AimPharmacotherapy is the primary treatment strategy in major depression. However, two‐thirds of patients remain depressed after the initial antidepressant treatment. Augmented cognitive behavioral therapy (CBT) for pharmacotherapy‐resistant depression in primary mental health care settings proved effective and cost‐effective. Although we reported the clinical effectiveness of augmented CBT in secondary mental health care, its cost‐effectiveness has not been evaluated. Therefore, we aimed to compare the cost‐effectiveness of augmented CBT adjunctive to treatment as usual (TAU) and TAU alone for pharmacotherapy‐resistant depression at secondary mental health care settings.MethodsWe performed a cost‐effectiveness analysis at 64 weeks, alongside a randomized controlled trial involving 80 patients who sought depression treatment at a university hospital and psychiatric hospital (one each). The cost‐effectiveness was assessed by the incremental cost‐effectiveness ratio (ICER) that compared the difference in costs and quality‐adjusted life years, and other clinical scales, between the groups.ResultsThe ICERs were JPY −15 278 322 and 2 026 865 for pharmacotherapy‐resistant depression for all samples and those with moderate/severe symptoms at baseline, respectively. The acceptability curve demonstrates a 0.221 and 0.701 probability of the augmented CBT being cost‐effective for all samples and moderate/severe depression, respectively, at the threshold of JPY 4.57 million (GBP 30 000). The sensitivity analysis supported the robustness of our results restricting for moderate/severe depression.ConclusionAugmented CBT for pharmacotherapy‐resistant depression is not cost‐effective for all samples including mild depression. In contrast, it appeared to be cost‐effective for the patients currently manifesting moderate/severe symptoms under secondary mental health care.
The effects of parenting styles and parental positivity on preschoolers’ self‐perception
Authors: Pali Emily C. , Marshall Riley L. , DiLalla Lisabeth Fisher 
Published: August 2021

AbstractSelf‐esteem has implications for a wide variety of psychological problems. This study sought to determine whether parenting practices at ages 3 and 4 years contributed to 5‐year‐old children's self‐perception, a precursor to later self‐esteem. Data came from a longitudinal study in which preschool twin or triplet children were tested within a month of their birthdays; complete data were available for 263 children tested at ages 4 and 5 years and for 211 children tested at ages 3 and 5 years. As part of testing at ages 3 and 4, children and parents engaged in a puzzle task for 10 min; their behaviors were coded by trained raters. Parenting variables of verbal warmth, positive affect, permissive discipline, and sensitivity were coded. At age 5, children's self‐perception was assessed using the Pictorial Scale of Perceived Competence and Social Acceptance for Young Children. Results showed that parental positive affect and sensitivity at age 4 predicted increased maternal acceptance at age 5, and permissive discipline predicted decreased peer acceptance scores for girls, but not boys. Additionally, parental verbal warmth at age 3 predicted higher peer acceptance scores at age 5. Finally, boys who experienced increases in parent positive affect from ages 3 to 4 showed higher peer acceptance scores at age 5. This study provides evidence that parenting is an important factor in the development of preschool children's self‐perception.
Ideology and compliance with health guidelines during the COVID‐19 pandemic: A comparative perspective
Authors: Becher Michael , Stegmueller Daniel , Brouard Sylvain , Kerrouche Eric 
Published: August 2021

AbstractObjectiveWe measure the prevalence of noncompliance with public health guidelines in the COVID‐19 pandemic and examine how it is shaped by political ideology across countries.MethodsA list experiment of noncompliance and a multi‐item scale of health‐related behaviors were embedded in a comparative survey of 11,000 respondents in nine OCED countries. We conduct a statistical analysis of the list experiment capturing degrees of noncompliance with social distancing rules and estimate ideological effect heterogeneity. A semiparametric analysis examines the functional form of the relationship between ideology and the propensity to violate public health guidelines.ResultsOur analyses reveal substantial heterogeneity between countries. Ideology plays an outsized role in the United States. No association of comparable magnitude is found in the majority of the other countries in our study. In many settings, the impact of ideology on health‐related behaviors is nonlinear.ConclusionOur results highlight the importance of taking a comparative perspective. Extrapolating the role of ideology from the United States to other advanced industrialized societies might paint an erroneous picture of the scope of possible nonpharmaceutical interventions. Heterogeneity limits the extent to which policymakers can learn from experiences across borders.
Decomposition of extensive and intensive margin impacts of trade policies
Authors: Zhao Xin , Luckstead Jeff , Devadoss Stephen 
Published: August 2021

AbstractUsing a multi‐region heterogeneous‐firm trade model, this paper develops a method to decompose volumes and values of domestic sales, bilateral trade, total production and consumption into their intensive and extensive margins. With the free‐entry condition, the extensive margin is further decomposed into two subcategories: operating‐extensive margin and entrance/exit‐extensive margin. This method can provide ex ante predictions on gains and losses in the margins of member and nonmember countries following a trade agreement. We apply our decomposition methods to quantitatively analyse the impacts of CETA between Canada and the European Union on the world processed food industry.
Cryogenian glaciostatic and eustatic fluctuations and massive Marinoan-related deposition of Fe and Mn in the Urucum District, Brazil
Authors: Freitas B.T. , Rudnitzki I.D. , Morais L. , Campos M.D.R. , Almeida R.P. , Warren L.V. , Boggiani P.C. , Caetano-Filho S. , Bedoya-Rueda C. , Babinski M. , Fairchild T.R. , Trindade R.I.F. 
Published: August 2021

Abstract
Global Neoproterozoic glaciations are related to extreme environmental changes and the reprise of iron formation in the rock record. However, the lack of narrow age constraints on Cryogenian successions bearing iron-formation deposits prevents correlation and understanding of these deposits on a global scale. Our new multiproxy data reveal a long Cryogenian record for the Jacadigo Group (Urucum District, Brazil) spanning the Sturtian and Marinoan ice ages. Deposition of the basal sequence of the Urucum Formation was influenced by Sturtian continental glaciation and was followed by a transgressive interglacial record of &gt;600 m of carbonates that terminates in a glacioeustatic unconformity. Overlying this, there are up to 500 m of shale and sandstone interpreted as coeval to global Marinoan glacial advance. Glacial outwash delta deposits at the top of the formation correlate with diamictite-filled paleovalleys and are covered by massive Fe and Mn deposits of the Santa Cruz Formation and local carbonate. This second transgression is related to Marinoan deglaciation. Detrital zircon provenance supports glaciostatic control on Cryogenian sedimentary yield at the margins of the Amazon craton. These findings reveal the sedimentary response to two marked events of glacioeustatic incision and transgression, culminating in massive banded iron deposition during the Marinoan cryochron.