bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal toxicity of targeted therapies for renal cell carcinoma in patients with normal and impaired kidney function
Authors: Mielczarek Łukasz , Brodziak Anna , Sobczuk Paweł , Kawecki Maciej , Cudnoch-Jędrzejewska Agnieszka , Czarnecka Anna M. 
Published: March 2021

AbstractThe introduction of novel targeted therapies during the last 2 decades has led to a significant improvement in patients' clinical outcomes with renal cell carcinoma. However, this improvement came at the price of a whole new spectrum of adverse events, including renal toxicity. Systemic treatment of patients with kidney neoplasms who often present with impairment of kidney function, even prior to treatment, poses an increasing diagnostic and therapeutic challenge for clinicians. Common lifestyle-related comorbidities, i.e., hypertension and diabetes, may contribute to further impairment of kidney function. The lack of official guidelines and the exclusion of patients with reduced kidney function from the clinical trials of recently approved drugs complicate the issue even further. Early detection and correct management of renal toxic effects are crucial to preserve kidney function and ensure the optimal administration of life-prolonging therapies. This review presents detailed information on the renal toxicities of three groups of drugs commonly used in renal cell carcinoma treatment: tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors, and immune checkpoint inhibitors. We outline the incidence and underlying mechanisms of renal adverse effects with a focus on patients on renal replacement therapy, as well as present suggestions for their management.
Systematic evaluation of laryngeal impairment in Sjögren’s syndrome
Authors: Graf S. , Kirschstein L. , Knopf A. , Mansour N. , Jeleff-Wölfler O. , Buchberger A. M. S. , Hofauer B. 
Published: March 2021

Abstract
Introduction
Sjögren’s syndrome (SjS) causes malfunction of the salivary and lacrimal glands. Consequently, patients suffer from xerostomia and keratoconjunctivitis sicca. This can further affect the voice and swallowing function resulting in an impaired quality of life. Aim of this study is the systematic evaluation of the impact on voice and swallowing-related quality of life in patients with SjS.

Material and methods
SjS patients were classified according to the American–European Consensus Group (AECG) criteria; antibodies to Ro (SS-A) or La (SS-B) antigens were detected, ESSPRI was completed. We used the following quality of life questionnaires: EORTC QLQ H&N 35, Anderson Dysphagia Inventory (ADI) and Voice Handicap Index (VHI). Patients additionally received a detailed phoniatric examination (auditory perception, videostroboscopy, acoustic analysis, Dysphonia Severity Index (DSI), aerodynamics measurements).

Results
Almost all the 54 patients (96.3%) had a limited quality of life due to their swallowing problems and 48% due to their voice problems. Both values correlated significantly with the degree of xerostomia. In the phoniatric examination, 77.8% had an increased DSI and two-thirds had abnormalities in videostroboscopy.

Conclusions
A reasonable impairment of quality of life in patients with SjS due to the limitations in voice and swallowing function was observed. As SjS does not limitate life expectancy, preservation of quality of life is important. Detection of voice and swallowing problems as potential reasons for quality of life impairment should be detected and, if diagnosed, treated accordingly.
An examination of five theoretical foundations associated with localized thermosensory testing
Authors: Temel Mevra , Johnson Andrew A. , Havenith George , Arnold Josh T. , West Anna M. , Lloyd Alex B. 
Published: March 2021

Abstract
Purpose
To assess five theoretical foundations underlying thermosensory testing using local thermal stimuli.

Methods
Thermal sensation, discomfort and the confidence of thermal sensation scores were measured in 9 female and 8 male volunteers in response to 17 physical contact temperature stimuli, ranging between 18–42 °C. These were applied to their dorsal forearm and lateral torso, across two sessions.

Results
Thermal sensation to physical temperature relationships followed a positive linear and sigmoidal fit at both forearm (r2 = 0.91/r2 = 0.91, respectively) and lateral torso (r2 = 0.90/ r2 = 0.91, respectively). Thermal discomfort to physical temperature relationships followed second and third-order fits at both forearm (r2 = 0.33/r2 = 0.34, respectively) and lateral torso (r2 = 0.38/r2 = 0.39, respectively) test sites. There were no sex-related or regional site differences in thermal sensation and discomfort across a wide range of physical contact temperatures. The median confidence of an individual’s thermal sensation rating was measured at 86%.

Conclusion
The relation between thermal sensation and physical contact temperature was well described by both linear and sigmoidal models, i.e., the distance between the thermal sensation anchors is close to equal in terms of physical temperatures changes for the range studied. Participants rated similar thermal discomfort level in both cold and hot thermal stimuli for a given increase or decrease in physical contact temperature or thermal sensation. The confidence of thermal sensation rating did not depend on physical contact temperature.
High performance of multiplex fluorescence in situ hybridization to simultaneous detection of BCL2 and BCL6 rearrangements: useful application in the characterization of DLBCLs
Authors: Marino Federica Zito , Aquino Gabriella , Brunelli Matteo , Scognamiglio Giosuè , Pedron Serena , Ronchi Andrea , Cozzolino Immacolata , Sparano Lucianna , Botti Gerardo , Panico Luigi , De Chiara Anna , Franco Renato ,   on behalf of the Gruppo Ematopatologia Campano
Published: March 2021

AbstractChromosomal rearrangements involving BCL2, BCL6 and MYC are commonly found in the most frequent B cell lymphomas, namely follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs). Particularly, BCL2-rearrangement represents a diagnostic hallmark in FLs, whereas MYC translocation can occur simultaneously with BCL2 and/or BCL6 rearrangements, defining a specific category of DLBCLs with a poorer prognosis. In this study, we aim to validate the diagnostic performance of multiplex BCL2/BCL6 FISH approach in formalin-fixed paraffin-embedded FLs and DBCLs and cytological samples of DLBCL comparing to the classic set of single break-apart probes. We collected a series of lymphomas, including 85 DLBCLs, 45 FLs and 36 other B-cell lymphoma histotypes and 16 cytological samples of DLBCLs. MYC, BCL2 and BCL6 rearrangements were previously assessed by a classic FISH test using single break-apart probes. All samples were analysed by a multiplex FISH assay. In the FL series, 38 cases showed BCL2-R; in the DLBCLs series, MYC-R was detected in 21 out of 85 DLBCL patients, BCL2-R in 10 out of 85 and BCL6-R in 33 out of 85. In the DLBCL cytological series, MYC-R was detected in 4 out of 16, BCL2-R in 4 out of 16 and BCL6-R in 1 out of 16. Notably, in FFPE, 13 double-hit lymphomas (DHLs) and 3 triple-hit lymphomas (THLs) were detected; in the cytological series, only 3 DHL cases were observed. The dual BCL2/BCL6 FISH probe test results were fully concordant with the results obtained using classic BCL2 and BCL6 single break apart. Particularly, multiplex FISH to simultaneously detect BCL2-R and BCL6-R on a single slide could find a wide application in the characterisation of double- and triple-hit DLBCLs.
Liouville quantum gravity and the Brownian map III: the conformal structure is determined
Authors: Miller Jason , Sheffield Scott 
Published: March 2021

AbstractPrevious works in this series have shown that an instance of a $$\sqrt{8/3}$$

8
/
3

-Liouville quantum gravity (LQG) sphere has a well-defined distance function, and that the resulting metric measure space (mm-space) agrees in law with the Brownian map (TBM). In this work, we show that given just the mm-space structure, one can a.s. recover the LQG sphere. This implies that there is a canonical way to parameterize an instance of TBM by the Euclidean sphere (up to Möbius transformation). In other words, an instance of TBM has a canonical conformal structure. The conclusion is that TBM and the $$\sqrt{8/3}$$

8
/
3

-LQG sphere are equivalent. They ultimately encode the same structure (a topological sphere with a measure, a metric, and a conformal structure) and have the same law. From this point of view, the fact that the conformal structure a.s. determines the metric and vice-versa can be understood as a property of this unified law. The results of this work also imply that the analogous facts hold for Brownian and $$\sqrt{8/3}$$

8
/
3

-LQG surfaces with other topologies.
Internet of things to protect the environment: a technological transdisciplinary project to develop mathematics with ethical effects
Authors: Tortoriello F. S. , Veronesi I. 
Published: March 2021

AbstractIn a society that has to reconcile two areas which are conceptually very distant from each other, such as interdisciplinarity and specialization, the education for young people is essential to form a thought to understand complexity, thanks also to the stimuli deriving from increasingly powerful and interconnected technological and IT environments. So, it is essential to identify teaching–learning processes and methods that allow students to understand and act adequately with a constantly evolving reality. Transdisciplinary themes can be introduced to enrich the students' curriculum by anchoring them strongly to the wealth of emerging technologies, using their potential and designing educational activities focused on technology and attractive to the various spheres of knowledge. In this paper is presented an experimental activity of designing Smart objects in the Internet of Things conducted with students of the “Mathematical High School” project.
El Niño and forecastability of oil-price realized volatility
Authors: Bouri Elie , Gupta Rangan , Pierdzioch Christian , Salisu Afees A. 
Published: March 2021

AbstractWe forecast monthly realized volatility (RV) of the oil price based on an extended heterogenous autoregressive (HAR)-RV model that incorporates the role of the El Niño Southern Oscillation (ENSO), as captured by the Equatorial Southern Oscillation Index (EQSOI). Based on the period covering 1986 January to 2020 December and studying various rolling-estimation windows and forecast horizons, we find that the EQSOI has predictive value for oil-price RV particularly at forecast horizons from 2 to 4 years, and for rolling-estimation windows of length 4 to 6 years. We show that this result holds not only based on standard tests of out-of-sample predictability, but also under an asymmetric loss function.
Distributed detection of sequential anomalies in univariate time series
Authors: Schneider Johannes , Wenig Phillip , Papenbrock Thorsten 
Published: March 2021

AbstractThe automated detection of sequential anomalies in time series is an essential task for many applications, such as the monitoring of technical systems, fraud detection in high-frequency trading, or the early detection of disease symptoms. All these applications require the detection to findallsequential anomalies possiblyfaston potentially verylargetime series. In other words, the detection needs to be effective, efficient and scalable w.r.t. the input size. Series2Graph is an effective solution based on graph embeddings that are robust against re-occurring anomalies and can discover sequential anomalies of arbitrary length and works without training data. Yet, Series2Graph is no t scalable due to its single-threaded approach; it cannot, in particular, process arbitrarily large sequences due to the memory constraints of a single machine. In this paper, we propose our distributed anomaly detection system, short DADS, which is an efficient and scalable adaptation of Series2Graph. Based on the actor programming model, DADS distributes the input time sequence, intermediate state and the computation to all processors of a cluster in a way that minimizes communication costs and synchronization barriers. Our evaluation shows that DADS is orders of magnitude faster than S2G, scales almost linearly with the number of processors in the cluster and can process much larger input sequences due to its scale-out property.
Trade-offs Between Light and Nutrient Availability Across Gradients of Dissolved Organic Carbon Lead to Spatially and Temporally Variable Responses of Lake Phytoplankton Biomass to Browning
Authors: Isles Peter D. F. , Creed Irena F. , Jonsson Anders , Bergström Ann-Kristin 
Published: March 2021

AbstractNorthern lakes are experiencing widespread increases in dissolved organic carbon (DOC) that are likely to lead to changes in pelagic phytoplankton biomass. Pelagic phytoplankton biomass responds to trade-offs between light and nutrient availability. However, the influence of DOC light absorbing properties and carbon–nutrient stoichiometry on phytoplankton biomass across seasonal or spatial gradients has not been assessed. Here, we analyzed data from almost 5000 lakes to examine how the carbon–phytoplankton biomass relationship is influenced by seasonal changes in light availability, DOC light absorbing properties (carbon-specific visual absorbance, SVA420), and DOC–nutrient [total nitrogen (TN) and total phosphorus (TP)] stoichiometry, using TOC as a proxy for DOC. We found evidence for trade-offs between light and nutrient availability in the relationship between DOC and phytoplankton biomass [chlorophyll (chl)-a], with the shape of the relationship varying with season. A clear unimodal relationship was found only in the fall, particularly in the subsets of lakes with the highest TOC:TP. Observed trends of increasing TOC:TP and decreasing TOC:TN suggest that the effects of future browning will be contingent on future changes in carbon–nutrient stoichiometry. If browning continues, phytoplankton biomass will likely increase in most northern lakes, with increases of up to 76% for a 1.7 mg L−1increase in DOC expected in subarctic regions, where DOC, SVA420, DOC:TN, and DOC:TP are all low. In boreal regions with higher DOC and higher SVA420, and thus lower light availability, lakes may experience only moderate increases or even decreases in phytoplankton biomass with future browning.
Stream Macroinvertebrates and Carbon Cycling in Tangled Food Webs
Authors: Demars Benoît O. L. , Kemp Joanna L. , Marteau Baptiste , Friberg Nikolai , Thornton Barry 
Published: March 2021

AbstractThe annual global loss of organic carbon from terrestrial ecosystems into rivers is similar to the organic carbon stored in soils each year. Dissolved organic matter (DOM) flows through the food web to macroinvertebrates, but little is known about the effect of DOM increase on stream food webs and how much macroinvertebrates may contribute to the regulation of carbon fluxes in rivers. Using a before and after control impact (BACI) experimental design, we increased by 12% (+ 0.52 mg C L−1) the concentration of DOM in a stream for three weeks by adding sucrose, with a distinctive δ13C signature, to simulate a pulse of natural DOM supply from soils. We partitioned the diet of macroinvertebrates from carbon sources according to the green pathway (autotrophs) and detrital pathways (bacteria and terrestrial organic matter). Our flow food web approach based on C fluxes, with bacteria as a key node, showed the dominant contribution of the detrital pathways for macroinvertebrates in the reference stream. DOM addition induced changes in the diets of individual taxa, but did not have any strong effects on the relative overall contribution of the detrital pathways versus the green pathway. Autotrophic uptake of CO2 respired by bacteria was much larger than bacterial C flux to invertebrates (that is, the classic microbial loop) and allowed a significant fraction of natural allochthonous organic carbon to make its way to macroinvertebrates via autotrophs fixing CO2 respired by bacteria. Overall macroinvertebrates did not regulate directly to any great extent the flux of stream DOM towards downstream ecosystems.
Intra-body dynamics of d-serine reflects the origin of kidney diseases
Authors: Okushima Hiroki , Iwata Yukimasa , Hesaka Atsushi , Sugimori Eri , Ikeda Tatsuhiko , Nakane Maiko , Mita Masashi , Hayashi Terumasa , Isaka Yoshitaka , Kimura Tomonori 
Published: March 2021

Abstract
Introduction
d-Serine, present only in trace amounts in humans, is now recognized as a biomarker of chronic kidney disease (CKD). CKD is heterogeneous in its original kidney diseases, whose diagnoses require kidney biopsy. In this study, we examined whether the intra-body dynamics of d-serine, indexed by its blood and urinary levels, reflects the origin of kidney diseases.

Methods
Patients with six kinds of kidney disease undergoing kidney biopsy were enrolled in a single center. Levels of d- and l-serine were measured using two-dimensional high-performance liquid chromatography. The associations between the origin of kidney diseases and the intra-body dynamics of d-serine were examined using multivariate cluster analyses.

Results
Unlike the non-CKD profile, patients with CKD showed broadly-distributed profiles of intra-body dynamics of d-serine. The plasma level of d-serine plays a key role in the detection of kidney diseases, whereas a combination of plasma and urinary levels of d-serine distinguished the origin of CKD, especially lupus nephritis.

Conclusion
Intra-body dynamics of d-serine have the potential to predict the origin of kidney diseases. Monitoring of d-serine may guide specific treatments for the origin of kidney diseases.
Low-Degree Approximation of Random Polynomials
Authors: Diatta Daouda Niang , Lerario Antonio 
Published: March 2021

AbstractWe prove that with “high probability” a random Kostlan polynomial in $$n+1$$

n
+
1

many variables and of degree d can be approximated by a polynomial of “low degree” without changing the topology of its zero set on the sphere $$\mathbb {S}^n$$

S

n

. The dependence between the “low degree” of the approximation and the “high probability” is quantitative: for example, with overwhelming probability, the zero set of a Kostlan polynomial of degree d is isotopic to the zero set of a polynomial of degree $$O(\sqrt{d \log d})$$

O
(

d
log
d

)

. The proof is based on a probabilistic study of the size of $$C^1$$

C
1

-stable neighborhoods of Kostlan polynomials. As a corollary, we prove that certain topological types (e.g., curves with deep nests of ovals or hypersurfaces with rich topology) have exponentially small probability of appearing as zero sets of random Kostlan polynomials.
A numerical study of variational discretizations of the Camassa–Holm equation
Authors: Galtung Sondre Tesdal , Grunert Katrin 
Published: March 2021

AbstractWe present two semidiscretizations of the Camassa–Holm equation in periodic domains based on variational formulations and energy conservation. The first is a periodic version of an existing conservative multipeakon method on the real line, for which we propose efficient computation algorithms inspired by works of Camassa and collaborators. The second method, and of primary interest, is the periodic counterpart of a novel discretization of a two-component Camassa–Holm system based on variational principles in Lagrangian variables. Applying explicit ODE solvers to integrate in time, we compare the variational discretizations to existing methods over several numerical examples.
Eye Tracking Supported Human Factors Testing Improving Patient Training
Authors: Weiss Kerrin Elisabeth , Hoermandinger Christoph , Mueller Marcus , Schmid Daners Marianne , Potapov Evgenij V. , Falk Volkmar , Meboldt Mirko , Lohmeyer Quentin 
Published: March 2021

AbstractThe handling of left ventricular assist devices (LVADs) can be challenging for patients and requires appropriate training. The devices’ usability impacts patients’ safety and quality of life. In this study, an eye tracking supported human factors testing was performed to reveal problems during use and test the trainings’ effectiveness. In total 32 HeartWare HVAD patients (including 6 pre-VAD patients) and 3 technical experts as control group performed a battery change (BC) and a controller change (CC) as an everyday and emergency scenario on a training device. By tracking the patients’ gaze point, task duration and pump-off time were evaluated. Patients with LVAD support ≥1 year showed significantly shorter BC task duration than patients with LVAD support <1 year (p = 0.008). In contrast their CC task duration (p = 0.002) and pump-off times (median = 12.35 s) were higher than for LVAD support patients <1 year (median = 5.3 s) with p = 0.001. The shorter BC task duration for patients with LVAD support ≥1 year indicate that with time patients establish routines and gain confidence using their device. The opposite effect was found for CC task duration and pump-off times. This implies the need for intermittent re-training of less frequent tasks to increase patients’ safety.
Role of the Finnish forest industry in mitigating global change: energy use and greenhouse gas emissions towards 2035
Authors: Lipiäinen Satu , Vakkilainen Esa 
Published: March 2021

AbstractThe objective of this paper is to analyse role of forest industry in meeting energy and climate targets that aim to mitigating global change. Finland as an important forest industry country with the ambitious target of becoming carbon neutral by 2035 is selected to a target county. This study aims to present a plausible assessment of the future of the Finnish forest industry until 2035 based on literature and a scenario building approach. The focus is on energy use and fossil carbon dioxide (CO2) emissions. The results suggest that electricity consumption will decrease, whereas electricity production will increase, which indicates that forest industry can provide more renewable electricity to the grid. Heat consumption may even increase as a result from building new biorefineries, but those mills can most probably meet their heat demand by combusting biofuels. Changes in forest industry’s direct fossil CO2 emissions can reduce Finnish fossil CO2 emissions 2─4% in comparison to 2018. Biofuels production is likely to rise, but the extent remains to be seen. It is concluded that the Finnish forest industry can contribute significantly to meeting national climate policy targets, and forest industry in general can play a role in mitigating global change. Additionally, it was found that development of the Finnish forest industry will probably be limited by the requirement for sustainable wood harvesting, which may also be a problem for other forest industry countries.