bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a learning analytics‐based real‐time feedback approach on knowledge elaboration, knowledge convergence, interactive relationships and group performance in CSCL
Authors: Zheng Lanqin , Niu Jiayu , Zhong Lu 
Published: August 2021

AbstractLearning analytics (LA) has been widely adopted in research on education. However, most studies in the area have conducted LA after computer‐supported collaborative learning (CSCL) activities rather than during CSCL. To address this problem, this study proposed a LA‐based real‐time feedback approach based on a deep neural network model to improve CSCL performance. In total, 72 university students participated in the study and were randomly assigned to an experimental or control group. The students in the experimental group learned with the LA‐based real‐time feedback approach, whereas the students in the control group learned with the conventional online collaborative learning approach. To analyse the data, both quantitative and qualitative methods were adopted. The results indicated that the LA‐based real‐time feedback approach significantly promoted knowledge convergence, knowledge elaboration, interactive relationships and group performance. The interview results also confirmed the effectiveness of the proposed approach.
Practitioner notesWhat is already known regarding this topic

Learning analytics (LA) has been widely used in education.
Most studies in the area have presented LA results only after collaborative learning and have lacked real‐time analysis and feedback.
What this paper adds

A LA‐based real‐time feedback approach was proposed and validated in the computer‐supported collaborative learning (CSCL) context.
The experimental results indicated that the LA‐based real‐time feedback approach significantly promoted knowledge elaboration, knowledge convergence, interactive relationships and group performance.
Implications for practice and/or policy

To shed light on progress in CSCL, real‐time LA are recommended.
Deep neural network models, such as bidirectional encoder representations from transformers, can be adopted to automatically analyse online discussion transcripts.
Real‐time feedback based on LA results can promote CSCL performance.
Risk factors of hospitalisation for thrombosis in adults with primary immune thrombocytopenia, including disease‐specific treatments: a French nationwide cohort study
Authors: Lafaurie Margaux , Maquet Julien , Baricault Bérangère , Ekstrand Charlotta , Christiansen Christian F. , Linder Marie , Bahmanyar Shahram , Nørgaard Mette , Sailler Laurent , Lapeyre‐Mestre Maryse , Sommet Agnès , Moulis Guillaume 
Published: August 2021

SummaryWe aimed to assess the risk factors of venous thrombosis (VT) and arterial thrombosis (AT) in adults with primary immune thrombocytopenia (ITP), particularly in relation to treatments. The population comprised all incident primary ITP adults in France between 2009 and 2017 (FAITH cohort; NCT03429660) built in the national health database. Outcomes were the first hospitalisation for VT and AT. Multivariable Cox regression models included baseline risk factors, time‐varying exposure to ITP drugs, splenectomy and to cardiovascular drugs. The cohort included 10 039 patients. A higher risk of hospitalisation for VT was observed with older age, history of VT, history of cancer, splenectomy [hazard ratio (HR) 3·23, 95% confidence interval (CI) 2·26–4·61], exposure to corticosteroids (HR 3·55, 95% CI 2·74–4·58), thrombopoietin‐receptor agonists (TPO‐RAs; HR 2·28, 95% CI 1·59–3·26) and intravenous immunoglobulin (IVIg; HR 2·10, 95% CI 1·43–3·06). A higher risk of hospitalisation for AT was observed with older age, male sex, a history of cardiovascular disease, splenectomy (HR 1·50, 95% CI 1·12–2·03), exposure to IVIg (HR 1·85, 95% CI 1·36–2·52) and TPO‐RAs (HR 1·64, 95% CI 1·26–2·13). Rituximab was not associated with an increased risk. These findings help to estimate the risk of thrombosis in adult patients with ITP and to select treatment.
A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population‐based health data
Authors: Bishton Mark J. , Stilwell Peter , Card Tim R. , Lanyon Peter , Ban Lu , Elliss‐Brookes Lucy , Manson Jessica , Nanduri Vasanta , Earp Kate , Flower Luke , Amarnani Raj , Rankin Judith , Sen Ethan S. , Tattersall Rachel S. , Crooks Colin J. , Aston Jeanette , Siskova Veronika , West Joe , Bythell Mary 
Published: August 2021

SummaryWe assessed the validity of coded healthcare data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013–2018 using ICD‐10 codes D76.1, D76.2 and D76.3. Hospital records were reviewed to validate diagnoses. Out of 74 patients, 73 were coded D76.1 or D76.2 (positive predictive value 89·0% [95% Confidence Interval {CI} 80·2–94·9%]) with confirmed/probable HLH. For cases considered not HLH, 44/53 were coded D76.3 (negative predictive value 97·8% [95% CI 88·2–99·9%]). D76.1 or D76.2 had 68% sensitivity in detecting HLH compared to an established active case‐finding HLH register in Sheffield. Office for National Statistics (ONS) mortality data (2003–2018) identified 698 patients coded D76.1, D76.2 and D76.3 on death certificates. Five hundred and forty‐one were coded D76.1 or D76.2 of whom 524 (96·9%) had HLH in the free‐text cause of death. Of 157 coded D76.3, 66 (42·0%) had HLH in free text. D76.1 and D76.2 codes reliably identify HLH cases, and provide a lower bound on incidence. Non‐concordance between D76.3 and HLH excludes D76.3 as an ascertainment source from HES. Our results suggest electronic healthcare data in England can enable population‐wide registration and analysis of HLH for future research.
Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies
Authors: McGrath Megan , Hoyt Helen , Pence Andrea , Forman Stuart A. , Raines Douglas E. 
Published: August 2021

Background and PurposeIn addition to binding to the classical high‐affinity extracellular benzodiazepine binding site of the GABAA receptor, some benzodiazepines occupy transmembrane inter‐subunit anaesthetic sites that bind etomidate (β+/α− sites) or the barbiturate derivative R‐mTFD‐MPAB (α+/β− and γ+/β− sites). We aimed to define the functional effects of these interactions on GABAA receptor activity and animal behaviour.Experimental ApproachWith flumazenil blocking classical high‐affinity extracellular benzodiazepine site effects, modulation of GABA‐activated currents by diazepam, midazolam and flurazepam was measured electrophysiologically in wildtype and M2‐15′ mutant α1β3γ2L GABAA receptors. Zebrafish locomotive activity was also assessed in the presence of each benzodiazepine plus flumazenil.Key ResultsIn the presence of flumazenil, micromolar concentrations of diazepam and midazolam both potentiated and inhibited wildtype GABAA receptor currents. β3N265M (M2‐15′ in the β+/α− sites) and α1S270I (M2‐15′ in the α+/β− site) mutations reduced or abolished potentiation by these drugs. In contrast, the γ2S280W mutation (M2‐15′ in the γ+/β− site) abolished inhibition. Flurazepam plus flumazenil only inhibited wildtype receptor currents, an effect unaltered by M2‐15′ mutations. In the presence of flumazenil, zebrafish locomotion was enhanced by diazepam at concentrations up to 30 μM and suppressed at 100 μM, suppressed by midazolam and enhanced by flurazepam.Conclusions and ImplicationsBenzodiazepine binding to transmembrane anaesthetic binding sites of the GABAA receptor can produce positive or negative modulation manifesting as decreases or increases in locomotion, respectively. Selectivity for these sites may contribute to the distinct GABAA receptor and behavioural actions of different benzodiazepines, particularly at high (i.e. anaesthetic) concentrations.
Factors influencing rehabilitation effect in prelingually deafened late‐implanted cochlear implant users, and the construction of a nomogram
Authors: Liu Riyuan , Wang Qian , Jiao Qingshan , Ji Fei , Zhao Hui , Li Jianan , Yang Shiming 
Published: August 2021

AbstractObjectivesOur study aimed to identify potential factors that may influence rehabilitation outcomes in late‐implanted adolescents and adults with prelingual deafness and to construct a user‐friendly nomogram.DesignThis cross‐sectional study included 120 subjects under 30 years of age who had received cochlear implantation at a single medical centre. The Categories of Auditory Performance (CAP) scale was used to evaluate the rehabilitation outcomes. A nomogram was constructed by using the R and EmpowerStats software.ResultsUnivariate analysis indicated higher rates of auditory performance improvement in younger aged subjects. Residual hearing and regular implant use were more frequently seen among subjects with auditory performance improvement. Multivariate analysis identified residual hearing (Hazard Ratio, 6.11; 95% Confidence Interval, 1.83–20.41; p < .01), age group (Hazard Ratio, 0.31; 95% Confidence Interval, 0.14–0.83; p = .02) and regular CI use (Hazard Ratio, 7.79; 95% Confidence Interval, 2.50–24.20; p < .01) as independent predictors for auditory performance improvement. The nomogram's predictive performance was satisfactory as shown by the calibration curve and receiver operating characteristic (ROC) curve.ConclusionsFactors such as residual hearing, younger age and regular CI use are associated with auditory performance improvement in this cochlear implant user population. The nomogram model also demonstrates a satisfactory predictive performance.
Technical factors that minimize the occurrence of early graft failure in pancreas transplantation
Authors: Ryu Je Ho , Ko Hyo Jung , Shim Jae Ryong , Lee Tae Beom , Yang Kwang Ho , Kim Taeun , Choi Byung Hyun 
Published: August 2021

AbstractPancreatic transplantation is the only treatment for insulin‐dependent diabetes resulting in long‐term euglycemia without exogenous insulin. However, pancreatic transplantation has become debatable following the improvements in the results of islet transplantation and artificial pancreas. Therefore, surgeons who perform pancreas transplants require the best surgical technique that can minimize technical failure. We aimed to report our experiences with pancreatic transplantations.We transplanted 65 pancreatic grafts between 2015 and 2020. Except for one death due to hypoxic brain damage after surgery, no postoperative technical failure was observed. We usually perform duodeno‐duodenal anastomosis using the transperitoneal approach, with retrocolic placement of the graft pancreas.There was no leakage from the duodenum even after immunologic graft failure. To prevent venous thrombosis, which is the most common cause of technical failure, we used the inferior vena cava for anastomosis and added graft venoplasty with a patch of donor vena cava or aortic interposition graft to the bench procedure; subsequently, there were no cases of technical failure due to thrombosis post‐transplantation. Therefore, the 1‐year graft survival (insulin‐free) rate was more than 95%. The improving the surgical technique will maintain pancreatic transplantation as the best treatment for insulin‐dependent diabetes.
Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan
Authors: Naik Abhijit S. , Aqeel Jawad , Wang Su Q , Chowdhury Mahboob , He Kevin , Wiggins Roger C. 
Published: August 2021

AbstractLong‐term kidney transplant (KT) survival has remained relatively stagnant. Protocol biopsy studies suggest that glomerulosclerosis is a significant contributor to long‐term graft failure. We previously demonstrated that podocyte loss in the first year post‐transplantation predicted long‐term allograft survival. However, whether increased podocyte loss continues over the lifespan of a KT remains unclear. We performed a cross‐sectional analysis of 1182 urine samples from 260 KT recipients up to 19‐years after transplantation. Urine pellet (UP) mRNAs were assayed for podocyte (NPHS2/podocin and nephrin/NPHS1), distal tubule (aquaporin2), and profibrotic cytokine (TGFbeta1). Multivariable generalized estimating equations were used to obtain “population‐averaged” effects for these markers over time post‐KT. Consistent with early stresses both podocyte and tubular markers increased immediately post‐KT. However, only podocyte markers continued to increase long‐term. A role for hypertrophic stresses in driving podocyte loss over time is implied by their association with donor BMI, recipient BMI, and donor‐recipient BMI mismatch at transplantation. Furthermore, UP podocin mRNA was associated with urine TGFbeta1, proteinuria, and reduced estimated glomerular filtration rate, thereby linking podocyte injury to allograft fibrosis and survival. In conclusion we observed that podocyte loss continues long‐term post‐KT suggesting an important role in driving late graft loss.
990. NICOTIANA INGULBA
Authors: Chase Mark W. , Dodsworth Steven , Christenhusz Maarten J. M. 
Published: August 2021

SummaryNicotiana ingulba is returned to species level here. It is illustrated from plants cultivated at the Royal Botanic Gardens, Kew, which were grown from seeds collected in the Uluru‐Kata Tjuta National Park in the Northern Territory, Australia. Its taxonomic history, ecology, cytology, etymology and cultivation are discussed.
Advocacy for a citizen‐centric rule of law agenda: How do we bring the rule of law to life?
Authors: Merdzanovic Adis , Nicolaidis Kalypso 
Published: August 2021

AbstractHow do we best defend the rule of law against its attackers, both within the European Union and outside of it? Often, the rule of law has been perceived as a domain belonging to jurists, lawyers, bureaucrats, or politicians. Yet at its most fundamental, the rule of law needs to be thought of from a citizen's perspective. When enforced, it guarantees freedoms and liberties for citizens and enables us to live peacefully. In this article, we propose a citizen‐centric rule of law agenda based on a deep conviction that it is if and when it becomes a citizen‐based societal principle that its many attackers are best countered. We discuss the challenges and necessities of rule of law promotion and propose an assessment approach called the “living list”. We close with a call for citizen‐scholars to fight for the rule of law, the most precious human invention of all time.
Larval development in the Pacific oyster and the impacts of ocean acidification: Differential genetic effects in wild and domesticated stocks
Authors: Durland Evan , De Wit Pierre , Meyer Eli , Langdon Chris 
Published: August 2021

AbstractThe adaptive capacity of marine calcifiers to ocean acidification (OA) is a topic of great interest to evolutionary biologists and ecologists. Previous studies have provided evidence to suggest that larval resilience to high pCO2 seawater for these species is a trait with a genetic basis and variability in natural populations. To date, however, it remains unclear how the selective effects of OA occur within the context of complex genetic interactions underpinning larval development in many of the most vulnerable taxa. Here we evaluated phenotypic and genetic changes during larval development of Pacific oysters (Crassostrea gigas) reared in ambient (~400 µatm) and high (~1600 µatm) pCO2 conditions, both in domesticated and naturalized “wild” oysters from the Pacific Northwest, USA. Using pooled DNA samples, we determined changes in allele frequencies across larval development, from early “D‐stage” larvae to metamorphosed juveniles (spat), in both groups and environments. Domesticated larvae had ~26% fewer loci with changing allele frequencies across developmental stages and <50% as many loci affected by acidified culture conditions, compared to larvae from wild broodstock. Functional enrichment analyses of genetic markers with significant changes in allele frequency revealed that the structure and function of cellular membranes were disproportionately affected by high pCO2 conditions in both groups. These results indicate the potential for a rapid adaptive response of oyster populations to OA conditions; however, underlying genetic changes associated with larval development differ between these wild and domesticated oyster stocks and influence their adaptive responses to OA conditions.
The power and potential of BIOMAP to elucidate host‐microbiome interplay in skin inflammatory diseases
Authors: Alenius Harri , Sinkko Hanna , Moitinho‐Silva Lucas , Rodriguez Elke , Broderick Conor , Alexander Helen , Reiger Matthias , Hjelmsø Mathis Hjort , Fyhrquist Nanna , Olah Peter , Bryce Paul , Smith Catherine , Koning Frits , Eyerich Kilian , Greco Dario , van den Bogaard Ellen H. , Neumann Avidan U. , Traidl‐Hoffmann Claudia , Homey Bernhard , Flohr Carsten , Bønnelykke Klaus , Stokholm Jakob , Weidinger Stephan 
Published: August 2021

AbstractThe two most common chronic inflammatory skin diseases are atopic dermatitis (AD) and psoriasis. The underpinnings of the remarkable degree of clinical heterogeneity of AD and psoriasis are poorly understood and, as a consequence, disease onset and progression are unpredictable and the optimal type and time point for intervention are as yet unknown. The BIOMAP project is the first IMI (Innovative Medicines Initiative) project dedicated to investigating the causes and mechanisms of AD and psoriasis and to identify potential biomarkers responsible for the variation in disease outcome. The consortium includes 7 large pharmaceutical companies and 25 non‐industry partners including academia. Since there is mounting evidence supporting an important role for microbial exposures and our microbiota as factors mediating immune polarization and AD and psoriasis pathogenesis, an entire work package is dedicated to the investigation of skin and gut microbiome linked to AD or psoriasis. The large collaborative BIOMAP project will enable the integration of patient cohorts, data and knowledge in unprecedented proportions. The project has a unique opportunity with a potential to bridge and fill the gaps between current problems and solutions. This review highlights the power and potential of the BIOMAP project in the investigation of microbe‐host interplay in AD and psoriasis.
Individual’s pretreatment psychological symptoms and progress in couples therapy: A person‐centered analysis
Authors: Wu Qiong , Su Tom , McWey Lenore M. , Ledermann Thomas 
Published: August 2021

AbstractThis study examined how individual pretreatment symptoms (depression and anxiety) predicted longitudinal, relational processes in couples therapy (the therapeutic alliance and couple satisfaction). This study included 99 heterosexual couples receiving systemic couples therapy. Partners reported their individual pretreatment symptoms of depression and anxiety before intake. Each member reported their therapeutic alliance with the therapist at the end of sessions 2–8, as well as their couple satisfaction before intake and at the end of sessions 4 and 8. A Latent Profile Analysis revealed four profiles characterizing couples on their pretreatment psychological symptoms, namely both higher (where both members of the couple had higher depressive and anxiety symptoms), female higher, male higher, and both lower profiles. Furthermore, longitudinal, dyadic multilevel models revealed that men in male higher, female higher, and both higher profiles had higher initial alliance levels, compared to men in the both lower profile. In contrast, only female partners in the both higher profile had a higher initial therapeutic alliance than those in the both lower profile. Men in the both higher profile had faster reductions in their alliance, whereas other profiles did not predict changes in male or female alliance. Additionally, the male higher and both higher profiles predicted a lower initial level of couple satisfaction in males but not females. The profiles did not predict changes in couple satisfaction, which may be a result of lowered power due to missing data. Findings were discussed in the context of systemic family theory, with clinical implications for distressed couples.
Untangling local and remote influences in two major petrel habitats in the oligotrophic Southern Ocean
Authors: Jones Daniel C. , Ceia Filipe R. , Murphy Eugene , Delord Karine , Furness Robert W. , Verdy Ariane , Mazloff Matthew , Phillips Richard A. , Sagar Paul M. , Sallée Jean‐Baptiste , Schreiber Ben , Thompson David R. , Torres Leigh G. , Underwood Philip J. , Weimerskirch Henri , Xavier José C. 
Published: August 2021

AbstractOcean circulation connects geographically distinct ecosystems across a wide range of spatial and temporal scales via exchanges of physical and biogeochemical properties. Remote oceanographic processes can be especially important for ecosystems in the Southern Ocean, where the Antarctic Circumpolar Current transports properties across ocean basins through both advection and mixing. Recent tracking studies have indicated the existence of two large‐scale, open ocean habitats in the Southern Ocean used by grey petrels (Procellaria cinerea) from two populations (i.e., Kerguelen and Antipodes islands) during their nonbreeding season for extended periods during austral summer (i.e., October to February). In this work, we use a novel combination of large‐scale oceanographic observations, surface drifter data, satellite‐derived primary productivity, numerical adjoint sensitivity experiments, and output from a biogeochemical state estimate to examine local and remote influences on these grey petrel habitats. Our aim is to understand the oceanographic features that control these isolated foraging areas and to evaluate their ecological value as oligotrophic open ocean habitats. We estimate the minimum local primary productivity required to support these populations to be much <1% of the estimated local primary productivity. The region in the southeast Indian Ocean used by the birds from Kerguelen is connected by circulation to the productive Kerguelen shelf. In contrast, the region in the south‐central Pacific Ocean used by seabirds from the Antipodes is relatively isolated suggesting it is more influenced by local factors or the cumulative effects of many seasonal cycles. This work exemplifies the potential use of predator distributions and oceanographic data to highlight areas of the open ocean that may be more dynamic and productive than previously thought. Our results highlight the need to consider advective connections between ecosystems in the Southern Ocean and to re‐evaluate the ecological relevance of oligotrophic Southern Ocean regions from a conservation perspective.