bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic spillovers of COVID-19: case of Saudi Arabia
Authors: Ahmed Irfan , Medabesh Ali Mohammad , Mehrez Khadija H. , Shili Nedra , Socci Claudio , Deriu Stefano 
Published: November 2021

PurposeWith the global outbreak of COVID-19 that has made the economic activities standstill, countries have taken immediate measures to safeguard not only the human lives but also the economies. This study investigates empirically the lockdown impact of current pandemic on the Saudi economy.Design/methodology/approachThe study employs inoperability input–output model (IIOM) on the input–output table (IOT) of Saudi Arabia for the analysis.FindingsFindings show that with the closure of few sectors for the period of two months, the GDP declined to 6.49%. Findings also show a negative impact on consumption, investments and exports.Research limitations/implicationsOne limitation of current study is that it uses IOTs which lack primary and secondary income distribution that is vital for presenting complete interindustry connections in the analysis. The interindustry structures relate to the consumption structures which ultimately lead to the income distribution and affect the consumption behaviors of economic agents. Hence, the complete income circular flow is not incorporated in IIOM using IOT. The findings of current study would be well grounded if it endogenized the primary and secondary income distribution.Practical implicationsThe practical implication of this study is the use of IIOM for anticipating the potential loss against the backdrop of catastrophes and pandemics. The IIOM has the capability to predict the economic effects of disruptive events and hence the policy-makers can better predict and devise prudent policies to avoid the likely threats to the economy.Originality/valueThe current situation is unprecedented, and it is challenging for governments to forecast the economic repercussions. Several economic sectors have been inoperative due to lockdown implemented by the governments. This study empirically estimated the inoperability produced by the current pandemic. The findings are consistent with other estimated statistics, thereby proving the efficacy of IIOM to anticipate the economic repercussions of natural hazards.
The impact of applying knowledge in the technological pillars of Industry 4.0 on supply chain performance
Authors: Sawangwong Anurak , Chaopaisarn Poti 
Published: November 2021

PurposeThe purpose of the study is to investigate the impact of technological pillars of Industry 4.0 based on knowledge to adopt the supply chain performance of Thai small and medium-sized enterprises (SMEs) 4.0. In addition, to increase knowledge and understanding of how to apply knowledge in technology 4.0 to improve the efficiency of supply chains and organizations.Design/methodology/approachAn integrated model was developed from applying knowledge in five technological pillars of Industry 4.0 such as Internet of things (IoTs), cloud computing, big data and analytics, additive manufacturing and cyber-security. The bibliometric analysis was used to find the relationship between the technological pillars of Industry 4.0 and the literature review. The survey questionnaires were sent to Thai SME 4.0 (manufacturing aspect). Of these, 240 useable responses were received, resulting in a response rate of 65.84%, after then, the exploratory factor analysis (EFA), confirmatory factor analysis (CFA), structural equation modeling (SEM) and validity were used to evaluate the model through IBM SPSS 21 and AMOS 22.FindingsEFA showed the four groups of the technological pillars of Industry 4.0, such as support human, automation, real-time and security. These groups positively impact supply chain performance (increase delivery reliability, increase resource efficiency, decrease costs in the supply chain and reduce delivery time). Another important finding is that supply chain performance positively impacts organizational performance in profitability, return on investment (ROI) and sale growth.Originality/valueThis study is a model development to support the supply chain performance and increase understanding related to applying knowledge in technology 4.0 that remains unclear for SME 4.0.
International cluster research progress on strategic niche management: a bibliometric citation big data computing analysis
Authors: Ding Yingying , Xi Xi , He Yao 
Published: November 2021

PurposeTime analysis and institution analysis as well as journal analysis allow the study to show literature distribution in this research area. Research hotspots and trending among different times are revealed by network-structural properties and network-temporal property. The study aims to shed light on international cluster research progress on strategic niche management (SNM).Design/methodology/approachUsing searched literature data on SNM from 1991 to 2018 from the database of Web of Science (WOS), the article maps the citation network and completes the citation analysis based on bibliometric citation analysis.FindingsThese eight research streams reveal the development of SNM from theoretical description to target-oriented study and finally diversification analysis.Originality/valueThe paper identifies eight continuous research streams in SNM: sustainable transition, dynamical diversity, complexity, social-technical system, social innovation, social-cognitive evolution, emerging market and policy mix.
Risk assessment on drug production safety based on Grey-Analytic Network Process
Authors: Ge Jiaojiao , Peng Benhong , Wei Guo , Wan Anxia 
Published: November 2021

PurposeTo strengthen the correlation analysis on risk factors of drug production safety and reduce the influence due to fuzzy judgments, a safety risk assessment method based on Grey-Analytic Network Process (G-ANP) is proposed.Design/methodology/approachFirst, an index system evaluating drug production safety risk is constructed according to the “Good Manufacture Practice of Medical Products,” next the influence weight of each risk index is derived by using the Analytic Network Process, then the grey number of each risk index is determined by further utilizing the grey statistical theory, and finally the risk level of drug production is obtained.FindingsAn empirical study is conducted and the results support the feasibility and practicability to use G-ANP method for drug production safety risk evaluation. The results of the case show that it is feasible and practical to use G-ANP method for drug production safety risk evaluation.Originality/valueThe innovation lies in the use of G-ANP method to fully consider the interdependence and interaction between the risk factors of drug production safety, which improves the objectivity in judging the risk level of drug production and provides a scientific basis for pharmaceutical manufacturers to formulate further decisions and management in the case of insufficient quantification of risk factors. Based on the findings, more targeted suggestions are made to reduce the production risk of pharmaceutical enterprises.
The feasibility of cap‐assisted routine adult colonoscope for therapeutic endoscopic retrograde cholangiopancreatography in patients with Roux‐en‐Y reconstruction after total gastrectomy
Authors: Ni Jian Bo , Zhu Mei Ying , Li Kai , Dai Wei Ming , Lu Lun Gen , Wan Xin Jian , Wan Rong , Cai Xiao Bo 
Published: November 2021

ObjectivesEndoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux‐en‐Y reconstruction after total gastrectomy is difficult to be performed using routine tools. The aim of this study was to evaluate the feasibility and safety of cap‐assisted routine adult colonoscope (CARAC) for ERCP in these patients.MethodsSixteen consecutive patients with indications of ERCP who had previously undergone total gastrectomy with Roux‐en‐Y reconstruction at two tertiary care endoscopy centers were identified. All ERCP procedures were carried out by using CARAC. The success rate of reaching the papilla, biliary cannulation and procedure‐related adverse events were analyzed.ResultsThe papilla was successful reached in 11 (68.8%) of the 16 cases, and biliary cannulation was subsequently reached in eight (72.7%) of the 11 cases. The procedures succeeded in three patients by using a percutaneous–endoscopic rendezvous procedure after failed cannulation. Overall clinical success was achieved in 11 (68.8%) of 16 patients. Procedure‐related mild acute pancreatitis was observed in 25.0% (4/16) of the cases and mild cholangitis in 18.8% (3/16). No serious adverse events were reported.ConclusionsCARAC for therapeutic ERCP is safe and effective in treating patients with Roux‐en‐Y reconstruction after total gastrectomy.
Trends of stomach cancer survival: A systematic review of survival rates from population‐based cancer registration
Authors: Tuo Jia Yi , Bi Jing Hao , Yuan Hui Yun , Jiang Yu Fei , Ji Xiao Wei , Li Hong Lan , Xiang Yong Bing 
Published: November 2021

ObjectivesWe aimed to describe the pattern and time trends of survival from stomach cancer worldwide from population‐based cancer registers.MethodsA systematic search of PubMed, Web of Science, EMBASE, SEER and SinoMed for articles published up to 31 December 2020 was conducted. All eligible survival analyses of stomach cancer were collected and evaluated by countries or regions, periods, sex and age groups.ResultsOur review included 76 articles on stomach cancer survival rates and found that these rates had improved globally with time, although this increase was unremarkable. The highest 5‐year survival rate of 72.1% was observed in Japan (2004‐2007). The 5‐year relative and net survival, rates were relatively high in Korea and Japan, while they were fairly poor in Africa and India. Sex‐specific survival rates were higher in women than in men in America, Europe and Oceania, whereas they were relatively low in Asia. The poorest age‐specific 5‐year relative and net survival rates were observed in patients aged over 75 years.ConclusionsOver the past decades, patient prognosis of stomach cancer has gradually improved worldwide and survival rates in developed regions were higher than those in developing regions. White men and Asian women had a poorer survival than white women and Asian men. Younger patients had better survival rates than those aged over 75 years globally.
Pet therapy in the emergency department and ambulatory care: A systematic review and meta‐analysis
Authors: Gaudet Lindsay A. , Elliott Sarah A. , Ali Samina , Kammerer Elise , Stauffer Brandy , Felkar Bailey , Scott Shannon D. , Dennett Liz , Hartling Lisa 
Published: November 2021

AbstractBackgroundPet therapy, or animal‐assisted interventions (AAIs), has demonstrated positive effects for patients, families, and health care providers (HCPs) in inpatient settings. However, the evidence supporting AAIs in emergency or ambulatory care settings is unclear. We conducted a systematic review to evaluate the effectiveness of AAIs on patient, family, and HCP experience in these settings.MethodsWe searched (from inception to May 2020) Medline, Embase, Cochrane CENTRAL, PsycINFO, and CINAHL, plus gray literature, for studies assessing AAIs in emergency and ambulatory care settings on: (1) patient and family anxiety/distress or pain and (2) HCP stress. Screening, data extraction, and quality assessment were done in duplicate with conflicts adjudicated by a third party. Random‐effects meta‐analyses are reported as mean differences (MDs) or standardized mean differences (SMDs) and 95% confidence intervals (CIs), as appropriate.ResultsWe included nine randomized controlled trials (RCTs; 341 patients, 146 HCPs, 122 child caregivers), four before–after (83 patients), and one mixed‐method study (124 patients). There was no effect across three RCTs measuring patient‐reported anxiety/distress (n = 380; SMD = –0.36, 95% CI = –0.95 to 0.23, I2 = 81%), while two before–after studies suggested a benefit (n = 80; SMD = –1.95, 95% CI = –2.99 to –0.91, I2 = 72%). Four RCTs found no difference in measures of observed anxiety/distress (n = 166; SMD = –0.44, 95% CI = –1.01 to 0.13, I2 = 73%) while one before–after study reported a significant benefit (n = 60; SMD = –1.64, 95% CI = –2.23 to –1.05). Three RCTs found no difference in patient‐reported pain (n = 202; MD = –0.90, 95% CI = –2.01 to 0.22, I2 = 68%). Two RCTs reported positive but nonsignificant effects on HCP stress.ConclusionsLimited evidence is available on the effectiveness of AAIs in emergency and ambulatory care settings. Rigorous studies using global experience‐oriented (or patient‐identified) outcome measures are required.
Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial
Authors: Tsze Daniel S. , Lubell Tamar R. , Carter Robert C. , Chernick Lauren S. , DePeter Kerrin C. , McLaren Son H. , Kwok Maria Y. , Roskind Cindy G. , Gonzalez Ariana E. , Fan Weijia , Babineau Shannon E. , Friedman Benjamin W. , Dayan Peter S. 
Published: November 2021

AbstractBackgroundIntravenous ketorolac is commonly used for treating migraine headaches in children. However, the prerequisite placement of an intravenous line can be technically challenging, time‐consuming, and associated with pain and distress. Intranasal ketorolac may be an effective alternative that is needle‐free and easier to administer. We aimed to determine whether intranasal ketorolac is non‐inferior to intravenous ketorolac for reducing pain in children with migraine headaches.MethodsWe conducted a randomized double‐blind non‐inferiority clinical trial. Children aged 8–17 years with migraine headaches, moderate to severe pain, and requiring parenteral analgesics received intranasal ketorolac (1 mg/kg) or intravenous ketorolac (0.5 mg/kg). Primary outcome was reduction in pain at 60 min after administration measured using the Faces Pain Scale‐Revised (scored 0–10). Non‐inferiority margin was 2/10. Secondary outcomes included time to onset of clinically meaningful decrease in pain; ancillary emergency department outcomes (e.g. receipt of rescue medications, headache relief, headache freedom, percentage improvement); 24‐h follow‐up outcomes; functional disability; and adverse events.ResultsFifty‐nine children were enrolled. We analyzed 27 children who received intranasal ketorolac and 29 who received intravenous ketorolac. The difference in mean pain reduction at 60 min between groups was 0.2 (95% CI −0.9, 1.3), with the upper limit of the 95% CI being less than the non‐inferiority margin. There were no statistical differences between groups for secondary outcomes.ConclusionsIntranasal ketorolac was non‐inferior to intravenous ketorolac for reducing migraine headache pain in the emergency department.
Analysis of BNT162b2‐ and CVnCoV‐elicited sera and of convalescent sera toward SARS‐CoV‐2 viruses
Authors: Hein Sascha , Herrlein Marie‐Luise , Mhedhbi Ines , Bender Daniela , Haberger Vanessa , Benz Nuka , Eisert Jonathan , Stingl Julia , Dreher Michael , Oberle Doris , Schulze Jessica , Mache Christin , Budt Matthias , Hildt Christoph , Wolff Thorsten , Hildt Eberhard 
Published: November 2021

SummaryBackgroundThe mRNA vaccine BNT162b2 (Comirnaty, BioNTech/Pfizer) and the vaccine candidate CVnCoV (Curevac) each encode a stabilized spike protein of SARS‐CoV2 as antigen but differ with respect to the nature of the mRNA (modified versus unmodified nucleotides) and the mRNA amount (30 μg versus 12 μg RNA). This study characterizes antisera elicited by these two vaccines in comparison to convalescent sera.MethodsSera from BNT162b2 vaccinated healthcare workers, and sera from participants of a phase I trial vaccinated with 2, 4, 6, 8, or 12 μg CVnCoV and convalescent sera from hospitalized patients were analyzed by ELISA, neutralization tests, surface plasmon resonance (SPR), and peptide arrays.ResultsBNT162b2‐elicited sera and convalescent sera have a higher titer of spike‐RBD‐specific antibodies and neutralizing antibodies as compared to the CVnCoV‐elicited sera. For all analyzed sera a reduction in binding and neutralizing antibodies was found for the lineage B.1.351 variant of concern. SPR analyses revealed that the CVnCoV‐elicited sera have a lower fraction of slow‐dissociating antibodies. Accordingly, the CVnCoV sera almost fail to compete with the spike‐ACE2 interaction. The significance of common VOC mutations K417N, E484K, or N501Y focused on linear epitopes was analyzed using a peptide array approach. The peptide arrays showed a strong difference between convalescent sera and vaccine‐elicited sera. Specifically, the linear epitope at position N501 was affected by the mutation and elucidates the escape of viral variants to antibodies against this linear epitope.ConclusionThese data reveal differences in titer, neutralizing capacity, and affinity of the antibodies between BNT162b2‐ and CVnCoV‐elicited sera, which could contribute to the apparent differences in vaccine efficacy.
From subjective to objective: A pilot study on testicular radiomics analysis as a measure of gonadal function
Authors: De Santi Bruno , Spaggiari Giorgia , Granata Antonio RM , Romeo Marilina , Molinari Filippo , Simoni Manuela , Santi Daniele 
Published: November 2021

AbstractBackgroundThe connection between testicular ultrasound (US) parameters and testicular function, including both spermato‐ and steroidogenesis has been largely suggested, but their predictive properties are not routinely applied. Radiomics, a new engineering approach to radiological imaging, could overcome the visual limit of the sonographer.ObjectivesThis study is aimed at extracting objective testicular US features, correlating with testicular function, including both spermato‐ and steroidogenesis, using an engineering approach, in order to overcome the operator‐dependent subjectivity.Materials and methodsProspective observational pilot study from December 2019 to December 2020 on normozoospermic subjects and patients with semen variables alterations, excluding azoospermia. All patients underwent conventional semen analysis, pituitary‐gonadal hormones assessment, and testicular US, performed by the same operator. US images were analyzed by Biolab (Turin) throughout image segmentation, image pre‐processing, and texture features extraction.ResultsOne hundred seventy US testicular images were collected from 85 patients (age 38.6 ± 9.1 years). A total of 44 first‐order and advanced features were extracted. US inhomogeneity defined by radiomics significantly correlates with the andrologist definition, showing for the first time a mathematical quantification of a subjective US evaluation. Thirteen US texture features correlated with semen parameters, predicting sperm concentration, total sperm number, progressive motility, total motility and morphology, and with gonadotropins serum levels, but not with total testosterone serum levels. Classification analyses confirmed that US textural features predicted patients’ classification according to semen parameters alterations.ConclusionsRadiomics texture features qualitatively describe the testicular parenchyma with objective and reliable quantitative parameters, reflecting both the testicular spermatogenic capability and the action of pituitary gonadotropins. This is an innovative model in which US texture features represent a mirror of the pituitary‐gonadal homeostasis in terms of reproductive function.
Effect of diuretics on plasma aldosterone and potassium in primary hypertension: A systematic review and meta‐analysis
Authors: McNally Ryan J. , Farukh Bushra , Chowienczyk Philip J. , Faconti Luca 
Published: November 2021

AimBy contrast with drugs inhibiting the renin‐angiotensin‐aldosterone system (RAAS), diuretics stimulate renin release by the kidneys. Although plasma aldosterone (PA) is thought to be mainly regulated by RAAS activity, serum potassium has been shown to be an important factor in animal models and humans. Here we perform a systematic review and meta‐analysis of randomised controlled trials (RCT) in hypertension investigating the effects of diuretic therapy on PA and the correlation of change in PA with that of potassium and blood pressure (BP).MethodsThree databases were searched: MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL). Titles were first screened by title and abstract for relevance before full‐text articles were assessed for eligibility according to a predefined inclusion/exclusion criteria.ResultsA total of 1139 articles were retrieved, of which 42 met the prespecified inclusion/exclusion criteria. The average standardised difference in mean PA was similar for all classes of diuretic: thiazide/thiazide‐like 0.299 (95% confidence interval [CI] 0.150, 0.447), loop 0.927 (0.37, 1.49), MRA/potassium‐sparing 0.265 (0.173, 0.357) and combination 0.466 (0.137, 0.796),Q = 6.33,P = .097. In subjects untreated with another antihypertensive, there was a significant relationship between change in PA and change in systolic BP but no relationship with the change in potassium.ConclusionIn RCTs of diuretic therapy in hypertension, there is an increase in PA with all classes of diuretic and no significant between‐class heterogeneity. Change in PA is not related with potassium but correlates with the change in BP in subjects untreated with another antihypertensive medication.
Low‐carbohydrate diet and risk of cancer incidence: The Japan Public Health Center‐based prospective study
Authors: Cai Honglin , Sobue Tomotaka , Kitamura Tetsuhisa , Ishihara Junko , Nanri Akiko , Mizoue Tetsuya , Iwasaki Motoki , Yamaji Taiki , Inoue Manami , Tsugane Shoichiro , Sawada Norie 
Published: November 2021

AbstractEpidemiological evidence on the effects of a long‐term low‐carbohydrate diet (LCD) on cancer incidence remains sparse. We investigate the association between LCD and the risk of overall and specific cancer site incidence in a Japanese population‐based prospective cohort study among 90 171 participants aged 45‐74. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During a median 17.0 y of follow‐up, we identified 15 203 cancer cases. A higher overall LCD score was associated with increased overall cancer risk (HR = 1.08 [CI: 1.02‐1.14], P‐trend = .012), while it was associated with decreased gastric cancer (GC) risk (0.81 [0.71‐0.93], P‐trend = .006). A higher animal‐based LCD score was associated with higher risk of overall cancer (1.08 [1.02‐1.14], P‐trend = .003), colorectal cancer (CRC) (1.11 [0.98‐1.25], P‐trend = .018), rectal cancer (RC) (1.24 [1.00‐1.54], P‐trend = .025), lung cancer (LC) (1.16 [1.00‐1.34], P‐trend = .042), and lower risk of GC (0.90 [0.79‐1.01], P‐trend = .033). Furthermore, we found that plant‐based LCD score was related to lower GC incidence (0.87 [0.77‐0.99], P‐trend = .031). Additionally, adjusted for plant fat intake amplified the adverse associations (overall cancer: 1.08 [1.02‐1.14] vs. 1.11 [1.05‐1.18]; CRC: 1.08 [0.95‐1.22] vs. 1.13 [0.99‐1.30]; LC: 1.14 [0.98‐1.33] vs. 1.19 [1.01‐1.41]). We conclude that LCD enriching with animal products was associated with increased overall cancer, CRC, and LC incidence. These adverse associations could be attenuated by plant fat consumption. LCD reduces the risk of developing GC. Long‐term adherence to LCD without paying attention to the balance between animal and plant food source consumption might cause adverse overall cancer incidence consequences.