bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formação inicial do enfermeiro quanto a temática saúde sexual e reprodutiva: revisão integrativa
Authors: Brasileiro Alessandra Leão , Lourinho Lídia Andrade 
Published: December 2021

As questões que envolvem saúde sexual e reprodutiva são pouco ou mesmo não são abordadas pelo fato de que os profissionais de saúde referem dificuldades em abordar essa temática e, além do desconforto em falar da sexualidade ou da saúde sexual de seus pacientes, muitos deles não se sentem preparados para exercer esse cuidado. Essa revisão integrativa trata-se de um recorte de uma dissertação. É uma reflexão sistematizada sobre o desenvolvimento de estratégias de articulação entre o mundo do trabalho, da aprendizagem e da sociedade, a partir do reconhecimento de avanços, fragilidades e fortalezas do atual modelo de atenção à saúde tendo como eixo central princípios do SUS e a necessidade de inovação das práticas e da formação em saúde. O objetivo é caracterizar pesquisas que abordem a temática saúde sexual e reprodutiva e que relacione com a formação inicial do enfermeiro. É necessário incentivos a pesquisa e a aplicabilidade sobre saúde sexual e reprodutiva, principalmente com a atualização da nomenclatura e o propósito no que significa o termo garantindo a dignidade e os direitos sexuais e reprodutivos da população. Foi possível concluir que é irrisório a quantidade de artigos que contemplam a termologia saúde sexual e reprodutiva, deixando claro o desfalque nesse assunto que é tão relevante para Saúde Pública. Mesmo assim, as publicações relevantes para a temática são de predominância das pesquisas voltadas para os profissionais da saúde e/ou para a população.
REZIM KEAMANAN MARITIM DALAM PENANGANAN PEMBAJAKAN KAPAL DI SELAT MALAKA
Authors: Oktavian Riskey 
Published: December 2021

Abstract
This article describes the form and performance of the Malacca Straits Patrol (MSP) cooperation as a maritime security regime in dealing with maritime piracy in the Straits of Malacca in the year 2008-2020. It is explored and analyzed using a theoretical approach of maritime security regimes, with the concept of maritime piracy, and the concept of maritime security. The research method used is qualitative based on case study and descriptive analysis. Sources of data were obtained from interviews and documentation with validated through triangulation of data sources and negative case analysis. The results of the study found the maritime piracy in the Straits of Malacca led to the development of dynamic threat perspective between littoral states and non-littoral user states depending on the priority of each states maritime interests to the strategic value of the Malacca Strait. This prompted the establishment of the Malacca Straits Patrol (MSP) cooperation as a form of maritime security regime with a cooperative security mechanism that has principles, norms, rules, and decision-making procedures aimed at dealing with maritime piracy of Malacca Strait through four programs: (1) Malacca Straits Sea Patrol (MSSP); (2) Eyes in the Sky Combined Maritime Air Patrols (EiS-CMAP); (3) Malacca Straits Patrol Intelligence Exchange Group (MSP-IEG); and (4) the Malacca Straits Patrol Joint Coordination Committee (MSP-JCC). It has a low level of effectiveness performance as the output product of the regime make outcome changes in the collective behavior of Indonesia, Malaysia, Singapore, and Thailand that optimum comply with a few rules of the game in the implementation of the MSSP, EiS CMAP, MSP-IEG, and MSP-JCC programs, because hampered by lack of capability and mutual mistrust. The results of these performances made the operationalization of the MSP regime to minimum, resulting in the unresolved problem of maritime piracy of the Malacca Strait according to the objectives MSP regime. Recommends for extending MSP to Strait of Singapore; increased capability of MSSP and EiS-CMAP; review the transparency information exchange of MSP-IEG; and increasing awareness and financial support, equipment, and training from interested non-littoral actors to littoral actors to make MSP more effective in dealing with piracy in the Straits of Malacca.

Keywords : Straits of Malacca; Maritime Piracy; Maritime Security; Malacca Straits Patrol; Maritime Security Regime
Bilateral Differential Topography—A Novel Topographic Algorithm for Keratoconus and Ectatic Disease Screening
Authors: Shen Yang , Xian Yiyong , Han Tian , Wang Xuanqi , Zhou Xingtao 
Published: December 2021

Purpose: The purpose of this study was to establish a novel bilateral differential topographic algorithm and assess its efficacy for screening of keratoconus and corneal ectasia before corneal refractive surgery.Methods: One hundred and sixty-one consecutive patients (115 men and 46 women, aged 22.8 ± 6.8 years) with keratoconus, including clinical keratoconus, subclinical keratoconus, forme fruste keratoconus (FFK), and corneal ectasia (KC group) and one hundred and seventy-four consecutive patients (97 men and 77 women, aged 25.1 ± 6.7 years) with ametropia (control group) visiting the Eye and ENT hospital of Fudan University from June 2018 to April 2021 were included. Bilateral differential keratometry, elevation, and pachymetry topographies were composed based on raw topographic data obtained by a Scheimpflug imaging anterior segment analyzer. Key bilateral differential characteristic parameters were calculated. SPSS 20 (SPSS Inc., IBM) was used for statistical analyses and the receiver operating characteristic (ROC) curves were used to determine the diagnostic efficacies.Results: Mann-Whitney tests detected that the front keratometry, front elevation, corneal pachymetry, and back elevation maximal, mean, and standard deviation values within a 1.5-mm radius of the bilateral differential topography were all significantly higher in the KC group than in the control group (all p-values &lt;0.001). The front keratometry mean (ΔFKmean) and standard deviation (ΔFKsd) and the front elevation standard deviation (ΔFEsd) and maximal (ΔFEmax) values within a 1.5-mm radius of the bilateral differential topography yielded the four highest accuracies (area under the ROC curve = 0.985, 0.985, 0.984, and 0.983, respectively) for discriminating KC cases (including FFK cases) from normal cases. Cut-off values of 0.75 diopters (D) for the ΔFKmean, 0.67 D for the ΔFKsd, 2.9 μm for the ΔFEsd, and 14.6 μm for the ΔFEmax had the highest sensitivities (95.7, 95.0, 96.9, and 95.0%, respectively) and specificities (96.0, 97.7, 94.8, and 95.4%, respectively).Conclusion: Bilateral differential topographic parameters may be efficient for the early detection of keratoconus and corneal ectasia secondary to corneal refractive surgery. This bilateral differential topographic algorithm may complement conventional diagnostic models by improving the sensitivity and specificity of screening for early keratoconus and ectasia before corneal refractive surgeries.
Screening of Hibiscus and Cinnamomum Plants and Identification of Major Phytometabolites in Potential Plant Extracts Responsible for Apoptosis Induction in Skin Melanoma and Lung Adenocarcinoma Cells
Authors: Kaushik Neha , Oh Hyunji , Lim Yeasol , Kumar Kaushik Nagendra , Nguyen Linh Nhat , Choi Eun Ha , Kim June Hyun 
Published: December 2021

Carcinogenesis is a major concern that severely affects the human population. Owing to persistent demand for novel therapies to treat and prohibit this lethal disease, research interest among scientists is drawing its huge focus toward natural products, as they have minimum toxicity comparable with existing treatment methods. The plants produce secondary metabolites, which are known to have the anticancer potential for clinical drug development. Furthermore, the use of nanocarriers could boost the solubility and stability of phytocompounds to obtain site-targeting delivery. The identification of potential phytochemicals in natural compounds would be beneficial for the synthesis of biocompatible nanoemulsions. The present study aimed to investigate the potential cytotoxicity of ethanol extracts of Hibiscus syriacus and Cinnamomum loureirii Nees plant parts on human skin melanoma (G361) and lung adenocarcinoma (A549) cells. Importantly, biochemical analysis results showed the presence of high phenol (50–55 µgGAE/mg) and flavonoids [42–45 µg quercetin equivalents (QE)/mg] contents with good antioxidant activity (40–58%) in C. loureirii Nees plants extracts. This plant possesses potent antiproliferative activity (60–90%) on the malignant G361 and A549 and cell lines correlated with the production of nitric oxide. Especially, C. loureirii plant extracts have major metabolites that exhibit cancer cell death associated with cell cycle arrest. These findings support the potential application of Cinnamomum for the development of therapeutic nanoemulsion in future cancer therapy.
Protection by Ankle Brace for Lower-Extremity Joints in Half-Squat Parachuting Landing With a Backpack
Authors: Jiang Tianyun , Tian Shan , Chen Tianhong , Fan Xingyu , Yao Jie , Wang Lizhen 
Published: December 2021

Half-squat parachuting landing is a kind of activity with high impact force. Injuries on lower-extremity joints are common in half-squat parachuting landing and would be increased with a backpack. An ankle brace was used to prevent ankle injuries in landing. However, few quantitative studies reported about the protection of an ankle brace for lower-extremity joints in half-squat parachuting landing with a backpack. This study focused on evaluating the protective effects of an ankle brace in half-squat parachuting landing with a backpack. Seven male participants landed from 120 cm with a backpack and an ankle brace. Each participant performed three landing trials on every experimental condition. Kinetics and kinematics of the hip, knee, and ankle were analyzed. It was found that the ankle brace did not significantly affect the ground reaction force with backpack but increased the ground reaction force from 14.7 ± 2.0 bodyweight to 16.2 ± 1.9 bodyweight (p = 0.017) without the backpack. The ankle brace significantly (p &lt; 0.05) decreased the angular displacement, angular velocity, and angular acceleration of the ankle both without and with the backpack. In conclusion, the ankle brace could restrict ankle motion and significantly increase ground reaction force without the backpack. However, the ankle brace did not significantly influence ground reaction force and still restricted ankle motion with the backpack. Therefore, the ankle brace was more effective in half-squat parachuting landing with the backpack than no-backpack landing.
Calcium Glycerolate Catalyst Derived from Eggshell Waste for Cyclopentadecanolide Synthesis
Authors: Cheng Haijun , Wei Jiangli , Liang Min , Dai Suyi , Liu Xiongmin , Ma Li , Wang Hongyun , Lai Fang 
Published: December 2021

Abstract: The synthesis costs of macrolide musks are higher than those of other commercial musks. To make this process less expensive, eggshell waste was calcined at a low temperature to obtain a catalyst for the cyclopentadecanolide production via reactive distillation using a glycerol entrainer. X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy analyses of the original and recovered catalysts revealed that the main catalytic ingredient was calcium glycerolate (CaG) and not calcium diglyceroxide (CaDG). The basic strengths of CaG and CaDG obtained by Hammett indicators were 7.2 &lt; H_≤ 15.0 and 9.8 &lt; H_≤15.0, while the corresponding base amounts were 1.9 and 7.3 mmol/ g, respectively. Because CaG was soluble in glycerine, the catalyst was efficiently reused. The reaction product containing over 95.0% cyclopentadecanolide with a yield of 49.8% was obtained at a temperature of 190°C and catalyst amount of 12 wt% after 7 h of reaction. Thus, eggshell waste may be directly placed into the reaction mixture after calcination at 600°C to synthesise a large amount of cyclopentadecanolide within a relatively short time. The results of this work indicate that eggshell waste can serve as a potential eco-friendly and affordable catalyst source for the production of macrolide musks.
Core-Shell-Like Structured Co3O4@SiO2 Catalyst for Highly Efficient Catalytic Elimination of Ozone
Authors: Ding Jingya , Cheng Feng , Meng Zhen , Cao Yan , Han Fennv , Chen Dongbin , Cao Mingxiang , Zhang Guolin , Kang Jiahao , Xu Shuxiang , Xu Qi 
Published: December 2021

Co3O4 is an environmental catalyst that can effectively decompose ozone, but is strongly affected by water vapor. In this study, Co3O4@SiO2 catalysts with a core-shell-like structure were synthesized following the hydrothermal method. At 60% relative humidity and a space velocity of 720,000 h−1, the prepared Co3O4@SiO2 obtained 95% ozone decomposition for 40 ppm ozone after 6 h, which far outperformed that of the 25wt% Co3O4/SiO2 catalysts. The superiority of Co3O4@SiO2 is ascribed to its core@shell structure, in which Co3O4 is wrapped inside the SiO2 shell structure to avoid air exposure. This research provides important guidance for the high humidity resistance of catalysts for ozone decomposition.
Single-Cell RNA Sequencing of the Rat Carotid Arteries Uncovers Potential Cellular Targets of Neointimal Hyperplasia
Authors: Gao Xiao-Fei , Chen Ai-Qun , Wang Zhi-Mei , Wang Feng , Luo Shuai , Chen Si-Yu , Gu Yue , Kong Xiang-Quan , Zuo Guang-Feng , Chen Yan , Ge Zhen , Zhang Jun-Jie , Chen Shao-Liang 
Published: December 2021

Aims: In-stent restenosis (ISR) remains an Achilles heel of drug-eluting stents despite technical advances in devices and procedural techniques. Neointimal hyperplasia (NIH) is the most important pathophysiological process of ISR. The present study mapped normal arteries and stenotic arteries to uncover potential cellular targets of neointimal hyperplasia.Methods and Results: By comparing the left (control) and right (balloon injury) carotid arteries of rats, we mapped 11 clusters in normal arteries and 11 mutual clusters in both the control and experimental groups. Different clusters were categorized into 6 cell types, including vascular smooth muscle cells (VSMCs), fibroblasts, endothelial cells (ECs), macrophages, unknown cells and others. An abnormal cell type expressing both VSMC and fibroblast markers at the same time was termed a transitional cell via pseudotime analysis. Due to the high proportion of VSMCs, we divided them into 6 clusters and analyzed their relationship with VSMC phenotype switching. Moreover, N-myristoyltransferase 1 (NMT1) was verified as a credible VSMC synthetic phenotype marker. Finally, we proposed several novel target genes by disease susceptibility gene analysis, such as Cyp7a1 and Cdk4, which should be validated in future studies.Conclusion: Maps of the heterogeneous cellular landscape in the carotid artery were defined by single-cell RNA sequencing and revealed several cell types with their internal relations in the ISR model. This study highlights the crucial role of VSMC phenotype switching in the progression of neointimal hyperplasia and provides clues regarding the underlying mechanism of NIH.
Macrophage Inflammatory Protein-1 Alpha, a Potential Biomarker for Predicting Left Atrial Remodeling in Patients With Atrial Fibrillation
Authors: Chen Yung-Lung , Wang Hui-Ting , Lin Pei-Ting , Chuang Jiin-Haur , Yang Ming-Yu 
Published: December 2021

Objectives:Left atrial (LA) remodeling itself is an independent risk factor for ischemic stroke and mortality, with or without atrial fibrillation (AF). Macrophage inflammatory protein-1 alpha (MIP-1α) has been reported to be involved in the induction of autoimmune myocarditis and dilated cardiomyopathy. Little is known about whether MIP-1α can be used to predict LA remodeling, especially in patients with AF.Methods:We prospectively enrolled 78 patients who had received a cardiac implantable electronic device due to sick sinus syndrome in order to define AF accurately. AF was diagnosed clinically before enrollment, according to 12-lead electrocardiography (ECG) and 24-h Holter test in 54 (69%) patients. The serum cytokine levels and the mRNA expression levels of peripheral blood leukocytes were checked and echocardiographic study was performed on the same day within 1 week after the patients were enrolled into the study. The 12-lead ECG and 24-h Holter test were performed on the same day of the patients' enrollment, and the device interrogation was performed every 3 months after enrollment. The enrolled patients were clinically followed up for 1 year.Results:There was no difference in baseline characteristics, cytokine levels and mRNA expression between patients with and without AF. Larger LA volume was positively correlated with higher levels of MIP-1α (r= 0.461,p≤ 0.001) and the atrial high-rate episodes (AHREs) burden (r= 0.593,p&lt; 0.001), and negatively correlated with higher levels of transforming growth factor (TGF)-β1 (r= −0.271,p= 0.047) and TGF-β3 (r= −0.279,p= 0.041). The higher AHREs burden and MIP-1α level could predict LA volume independently. The mRNA expression ofRORCwas negatively associated with the MIP-1α level.Conclusions:This study showed that higher MIP-1α was significantly associated with LA remodeling and may have the potentials to predict LA remodeling in terms of a larger LA volume, and that circadian gene derangement might affect the expression of MIP-1α.
Doushantuo-Pertatataka—Like Acritarchs From the Late Ediacaran Bocaina Formation (Corumbá Group, Brazil)
Authors: Morais L. , Fairchild T. R. , Freitas B. T. , Rudnitzki I. D. , Silva E. P. , Lahr D. , Moreira A. C. , Abrahão Filho E. A. , Leme J. M. , Trindade R. I. F. 
Published: December 2021

Acritarchs, a polyphyletic group of acid-resistant organic-walled microfossils, dominate the eukaryotic microfossil record in the Proterozoic (2500–541 Ma) yet exhibit significant reduction in diversity and size at the transition to the Phanerozoic (541–520 Ma). Despite the difficulty of tracing phylogenetic relationships among acritarchs, changes in their complexity and diversity through time have allowed their use in paleoecological and biostratigraphic schemes. The Doushantuo-Pertatataka Ediacaran acritarch assemblage, for example, is usually considered as restricted to the early Ediacaran between 635 and 580 Ma. But similar, diverse acritarchs have been recovered from younger rocks in Mongolia and Arctic Siberia and are now reported here from phosphatized horizons of the upper Bocaina Formation (ca. 555 Ma), Corumbá Group, SW Brazil. In the overlying black limestones and shales of the latest Ediacaran Tamengo Formation (542 Ma) acritarch diversity is low, but the skeletal metazoans Cloudina and Corumbella are abundant. The Bocaina acritarch assemblage shares forms referable to the genera Leiosphaeridia, Tanarium, Asseserium and Megasphaera with the Doushantuo-Pertatataka assemblage, but also includes specimens similar to the Phanerozoic genus Archaeodiscina in addition to two new complex acritarchs. The first is covered by rounded low conical bumps, similar to Eotylotopalla but differs in having a distinct opening suggestive of greater (multicellular?) complexity. The second, identified here as Morphotype 1, is a double-walled acanthomorph acritarch with scattered cylindrical processes between the walls. The contrast in acritarch diversity and abundance between the Bocaina and Tamengo formations is likely due in part to paleoenvironmental and taphonomic differences (absence of the phosphatization window in the latter), as well as to the appearance of both suspension-feeding skeletal metazoans (Cloudina and Corumbella). The occurrence of Doushantuo-Pertatataka acritarchs in SW Brazil, northern Mongolia, and Arctic Siberia extend the biostratigraphic range of this assemblage up to the terminal Ediacaran Cloudina biozone.
Clinical Characteristics and Long-Term Recombinant Human Growth Hormone Treatment of 18q- Syndrome: A Case Report and Literature Review
Authors: Liu Shanshan , Chen Meiping , Yang Hongbo , Chen Shi , Wang Linjie , Duan Lian , Zhu Huijuan , Pan Hui 
Published: December 2021

Background18q- syndrome is a rare chromosomal disease caused by the deletion of the long arm of chromosome 18. Some cases with 18q- syndrome can be combined with growth hormone deficiency (GHD), but data on the efficacy of recombinant human growth hormone (rhGH) treatment in 18q- syndrome are limited.MethodsHere, we report one case of 18q- syndrome successfully treated with long-term rhGH supplement. Previously reported cases in the literature are also reviewed to investigate the karyotype–phenotype relationship and their therapeutic response to rhGH.ResultsA 7.9-year-old girl was referred for evaluation for short stature. Physical exam revealed proportionally short stature with a height of 111.10 cm (−3.02 SD score (SDS)), low-set ears, a high-arched palate, a small jaw, webbed neck, widely spaced nipples, long and tapering fingers, and cubitus valgus. Thyroid function test indicated subclinical hypothyroidism. The peak value of growth hormone was 10.26 ng/ml in the levodopa provocation test. Insulin-like growth factor 1 (IGF-1) was 126 ng/ml (57–316 ng/ml). Other laboratory investigations, including complete blood cell count, liver and kidney function, gonadal function, serum adrenocorticotropin levels, and serum cortisol levels, were all within normal ranges. Karyotype analysis showed 46, XX, del (18) (q21). L-Thyroxine replacement and rhGH treatment were initiated and maintained in the following 7 years. At the age of 14.8, her height has reached 159.5 cm with a height SDS increase of 2.82 SDS (from −3.02 SDS to −0.20 SDS). No significant side effects were found during the treatment. The literature review indicated the average rhGH treatment duration of 16 patients was 5.9 ± 3.3 years, and the average height SDS significantly increased from −3.12 ± 0.94 SDS to −1.38 ± 1.29 SDS after the rhGH treatment (p &lt; 0.0001).ConclusionThe main clinical manifestations of 18q- syndrome include characteristic appearance, intellectual disability, and abnormal genital development. The literature review suggested a significant height benefit for short stature with 18q- syndrome from long-term rhGH treatment.