bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomass-fuelled combined heat and power: integration in district heating and thermal-energy storage
Authors: Rezaei Masoud , Sameti Mohammad , Nasiri Fuzhan 
Published: March 2021

Abstract
Conventional approaches towards energy-system modelling and operation are based upon the system design and performance optimization. In system-design optimization, the thermal or mechanical characteristics of the systems providing for the heat or electricity demands were derived separately without integration with the energy source and without interaction with demand, which results in low-efficiency energy performance. This paper presents a key review on the integration of biomass-powered combined heat and power (BCHP) systems in district-heating systems as well as coupling with thermal-energy storage. In BCHP design, the appropriate sizing of the associated components as part of the district-heating system is very important to provide the optimal dispatch strategy as well as minimized cost and environmental impact while it co-operates with thermal-energy storage. Future strategies for the feasibility, evaluation and integration of biomass-powered energy systems in the context of district systems are also studied.
Is there a standardized practice for the development of international ulcerative colitis and Crohn’s disease treatment guidelines?
Authors: Goldowsky Alexander , Sen Rohan , Hoffman Gila , Feuerstein Joseph D 
Published: March 2021

Abstract

Background
Guidelines are published by international gastroenterology societies regarding the management of ulcerative colitis (UC) and Crohn’s disease (CD) to help clinicians to provide high-quality patient care. We examined the guidelines for the quality and strength of evidence used to develop the recommendations, methods for grading evidence, differences in disease-specific recommendations, conflicts of interest, and plans for guideline updates.

Methods
A systematic search was performed on PubMed using “ulcerative colitis,” “Crohn’s disease,” and “guidelines” in April 2019. International gastroenterology society websites were searched for UC- and CD-specific guidelines. Guidelines from 12 societies were examined by two authors. Chi-squared tests were used for comparing evidence-level grades, strength of recommendations, and reported conflicts of interest. Linear-regression modeling was used to evaluate the relationship between the number of authors and the number of recommendations in a given guideline.

Results
Of 28 guidelines reviewed, 25 (89%) used a total of three different systems to grade the level of evidence and 2 (7%) used an unknown system. Three (11%) reviewed guidelines did not provide a conflict-of-interest statement, while three (11%) provided a timeline for guideline updates. Of 1,265 total statements examined, 246 (19%) reported no grade of evidence quality or explicitly stated that the recommendation was based on “expert opinion.” One hundred and thirty-five (22%) UC recommendations were noted to be “weak/conditional” and 95 (16%) did not have a recommendation strength. Two hundred and forty-two (37%) CD recommendations were noted to be “weak/conditional” and 151 (23%) did not have a recommendation strength.

Conclusion
The majority of UC and CD guidelines are based on a low/very low quality of evidence and are further weakened due to the lack of homogeneity in specific aspects of management recommendations as well as conflicts of interest.
Assessment of postoperative risk factors for EEG abnormalities in routine clinical management after paediatric cardiopulmonary bypass
Authors: Li Meng-Yao , Lou Xiao-Bin , Cui Yan-Qin , Lin Rou-Yi , Ning Shu-Yao , Li Li-Juan , Li Jian-Bin , Huang Guo-Dong , Zou Ming-Hui , Ma Li , Chen Xin-Xin , Li Jia 
Published: March 2021

Abstract

OBJECTIVES
The postoperative risk factors for electroencephalogram(EEG) abnormalities after paediatric cardiopulmonary bypass (CPB) remain to be identified. We investigated the characteristics of EEG abnormalities and risk factors in routine clinical management post-CPB.

METHODS
EEG and cerebral oxygen saturation (ScO2) were monitored in 96 patients (aged 3 days, 37 months, median 5 months) for 72 h post-CPB. Clinical measurements included 4-hourly arterial and central venous pressure, arterial blood gases, doses of inotropic and vasoactive drugs, daily C-reactive protein (CRP) and NT-proB-type Natriuretic Peptide (NT-proBNP). Demographics, STAT categories and outcomes (duration of mechanical ventilation,CICU stay) were recorded. Un

RESULTS
Seizures occurred in 20 patients (20.8%) beginning at 0–48 hand lasting 10 min–31 h; background abnormalities occurred in 67 (69.8%) beginning at 0–8 h and lasting 4–48 h. Patients with EEG abnormalities had worse outcomes. In univariable regression, seizures positively correlated with STAT categories, CPB time, temperature, blood pressure, central venous pressure, NT-proBNP, CRP, lactate and epinephrine, negatively with ScO2 and PaCO2 (P &lt; 0.001 for lactate and epinephrine, P &lt; 0.1 for the remaining). The degree of background abnormalities positively correlated with STAT categories, CPB time, operative time, central venous pressure, milrinone, negatively with blood pressure (P = 0.0003–0.087); it negatively correlated with lower dose of epinephrine (P &lt; 0.001) and positively with higher dose (P = 0.03l). In multivariable regression, seizures positively correlated with epinephrine, lactate and temperature; the background abnormality correlations remain significant except for milrinone and operative time (P &lt; 0.001 for epinephrine, P &lt; 0.05 for the remaining).

CONCLUSIONS
Numerous perioperative risk factors are associated with EEG abnormalities post-CPB. The most significant and consistent risk factor is epinephrine.
Bayesian models for prediction of the set-difference in volleyball
Authors: Ntzoufras Ioannis , Palaskas Vasilis , Drikos Sotiris 
Published: March 2021

AbstractWe study and develop Bayesian models for the analysis of volleyball match outcomes as recorded by the set-difference. Due to the peculiarity of the outcome variable (set-difference) which takes discrete values from $-3$ to $3$, we cannot consider standard models based on the usual Poisson or binomial assumptions used for other sports such as football/soccer. Hence, the first and foremost challenge was to build models appropriate for the set-difference of each volleyball match. Here we consider two major approaches: (a) an ordered multinomial logistic regression model and (b) a model based on a truncated version of the Skellam distribution. For the first model, we consider the set-difference as an ordinal response variable within the framework of multinomial logistic regression models. Concerning the second model, we adjust the Skellam distribution to account for the volleyball rules. We fit and compare both models with the same covariate structure as in Karlis & Ntzoufras (2003). Both models are fitted, illustrated and compared within Bayesian framework using data from both the regular season and the play-offs of the season 2016/17 of the Greek national men’s volleyball league A1.
Exploratory Analysis of the Economically Justifiable Price of a Hypothetical RSV Vaccine for Older Adults in the Netherlands and the United Kingdom
Authors: Zeevat F , Luttjeboer J , Paulissen J H J , van der Schans J , Beutels P , Boersma C , Postma M J ,   RESCEU Investigators, Nair Harish , Campbell Harry , Openshaw Peter , Beutels Philippe , Bont Louis , Pollard Andrew , Molero Eva , Martinon-Torres Federico , Heikkinen Terho , Meijer Adam , Kølsen Fischer Thea , van den Berge Maarten , Giaquinto Carlo , Kieffer Alexia , Demont Clarisse , Gallichan Scott , Dormitzer Philip , Leach Amanda , Dillon Laura , Aerssens Jeroen , Rosen Brian 
Published: March 2021

Abstract

Background
In older adults, the burden of respiratory syncytial virus (RSV) resembles that of influenza and may even be considered worse due to the lack of preventive interventions. This study was performed to identify the available literature on RSV infection in older adults, and to provide updated exploratory results of the cost-effectiveness of a hypothetical RSV vaccine in the Netherlands and the United Kingdom.

Methods
A literature search was performed in Medline and EMBASE on 11 November 2019, which served as input for a static decision-tree model that was used to estimate the EJP, for an RSV vaccine applying different willingness-to-pay (WTP) thresholds. WTP thresholds applied were €20 000 and €50 000 per quality-adjusted life-year for the Netherlands, and £20 000 and £30 000 per quality-adjusted life-year for the United Kingdom. Analyses were—in line with country-specific guidelines—conducted from a societal perspective for the Netherlands and a third-party payer perspective for the United Kingdom. The robustness of the cost-effectiveness results was tested in sensitivity analysis.

Results
After screening the literature, 3 studies for the Netherlands and 6 for the United Kingdom remained to populate the country-specific models. In the base case analysis for the Netherlands (mean RSV incidence, 3.32%), justifiable vaccine prices of €16.38 and €50.03 were found, based on applying the lower and higher WTP thresholds, respectively. Similarly, for the United Kingdom (mean incidence, 7.13%), vaccine prices of £72.29 and £109.74 were found, respectively.

Conclusion
RSV vaccination may well be cost-effective in both the Netherlands and the United Kingdom, depending on the exact RSV incidence, vaccine effectiveness and price. However, sensitivity analysis showed that the results were robust based on varying the different parameter estimates and assumptions. With RSV vaccines reaching the final stages of development, a strong need exists for cost-effectiveness studies to understand economically justifiable pricing of the vaccine.
Lack of Detection of Haemophilus influenzae Using Adult Blood Culture Bottles Inoculated at Low Volumes
Authors: Freeman Tanner J , Krenke Charlene , Mitchell Stephanie L 
Published: March 2021

Abstract

Background
Based on guidelines from the Infectious Diseases Society of America and the American Society for Microbiology, many pediatric hospitals are implementing weight-based collection guidelines for blood cultures. To simplify the process of culture collection, there has been interest in validating the use of adult blood culture bottles with low volumes, which may allow for a “one size fits all” bottle.

Method
This study examined 9 clinically relevant organisms (Staphylococcus aureus, Streptococcus pneumonia, Streptococcus agalactiae, Enterococcus faecium, Escherichia coli, Haemophilus influenzae, Pseudomonas aeruginosa, Candida glabrata, and Candida albicans) utilizing the BD BacTec system at various inoculation volumes and dilutions to assess performance, based on time to positivity, of adult blood culture bottles compared with pediatric blood culture bottles.

Results
There was a lack of detection of H. influenzae using adult blood culture bottles inoculated at low volumes, whereas pediatric bottles detected H. influenzae regardless of dilution–volume combinations tested.

Conclusions
Exclusive use of adult blood culture bottles may not detect H. influenzae bacteremia in the setting of low-volume inoculum.
Scientific and Legal Mechanisms for Addressing Model Uncertainties: Negotiating the Right Balance in Finnish Judicial Review?
Authors: Paloniitty Tiina , Kotamäki Niina 
Published: March 2021

Abstract
Environmental models are ubiquitous in assessing the environmental impacts of planned projects. Modelling is an inferential process and includes various mechanisms to address the uncertainty of the outcome. In this article, we acknowledge the continuum of uncertainty assessments and identify the legal mechanisms with which Finnish judicial review—characterised by broad scope of review and in-house expert judges—has encountered model uncertainty. Closely examining 10 waters-related cases heard by the Supreme Administrative Court of Finland, we explain the porous yet substantial boundary between science and law revealed by the cases. The cases demonstrate the elegance with which courts can strike a balance between the contingent precautionary principle, gradually decreasing scientific uncertainty, and the procedural constraints under which they operate. We conclude by analysing the traces towards reciprocality and adaptivity the cases reveal, encouraged by the iterative modelling mechanism and challenged by the constitutional restrictions on the scope of review.
Populism and Securitization: The Corrosion of Elite Security Authority in a US–Mexico Border State
Authors: Slaven Mike 
Published: March 2021

AbstractPopulists have often seemed influential in the securitization of migration, in great part through pressuring non-populist governing elites into “mainstreaming” more hardline immigration positions. This article asks why, given the presumption in securitization literatures that elite insiders possess strong authority in defining security, non-populist governing elites often in fact cede ground to populist challengers who paint immigration as a threat. Securitization and political science literatures paint very different pictures of elite–challenger dynamics, but populist and securitization claims possess key ideational similarities, in relation to the holism and autonomy of the political community, and the apoliticism of pursuing purportedly self-evident goals. However, populism articulates securitarian concepts through a moralized anti-elitism that impugns elite authority, portraying governing elites as corruptly inert toward threats facing “the people.” This article explores how this ideational relationship may affect securitization processes through a process-tracing study of the populist radical right's successful pressuring of governing elites to securitize migration in the US state of Arizona. There, populists’ moralized accusations of corrupt elite inaction toward urgent security threats moved governing elites to adopt positions intended to demonstrate responsiveness to public border-security anxieties, thereby inscribing securitization. Taking an “ideational” view of both concepts shows how they can form a politically influential account of “common sense.” By undermining elite security authority—thus inverting the typically theorized power dynamics of securitization—populism may open new pathways for securitized policies to emerge.
Papain-like cysteine proteases are required for the regulation of photosynthetic gene expression and acclimation to high light stress
Authors: Alomrani Sarah , Kunert Karl J , Foyer Christine H 
Published: March 2021

Abstract
Chloroplasts are considered to be devoid of cysteine proteases. Using transgenic Arabidopsis lines expressing the rice cystatin, oryzacystatin I (OC-I), in the chloroplasts (PC lines) or cytosol (CYS lines), we explored the hypothesis that cysteine proteases regulate photosynthesis. The CYS and PC lines flowered later than the wild type (WT) and accumulated more biomass after flowering. In contrast to the PC rosettes, which accumulated more leaf chlorophyll and carotenoid pigments than the WT, the CYS lines had lower amounts of leaf pigments. High-light-dependent decreases in photosynthetic carbon assimilation and the abundance of the Rubisco large subunit protein, the D1 protein, and the phosphorylated form of D1 proteins were attenuated in the CYS lines and reversed in the PC lines relative to the WT. However, the transgenic lines had higher amounts of LHC, rbcs, pasbA, and pasbD transcripts than the WT, and also showed modified chloroplast to nucleus signalling. We conclude that cysteine proteases accelerate the reconfiguration of the chloroplast proteome after flowering and in response to high-light stress. Inhibition of cysteine proteases, such as AtCEP1, slows chloroplast protein degradation and stimulates photosynthetic gene expression and chloroplast to nucleus signalling, enhancing stress tolerance traits.
Use of Sundt Clip Graft for the Treatment of Intracranial Aneurysms: 2-Dimensional Operative Video
Authors: Rinaldo Lorenzo , Meyer Fredric B , Van Gompel Jamie J 
Published: March 2021

Abstract
Dr Thoralf Sundt III joined the department of neurosurgery at Mayo Clinic in 1969 and served as chairman from 1980 until his death in 1992. Dr Sundt was a pioneer in the field of cerebrovascular neurosurgery and among his many contributions to neurosurgical technology was the introduction of the Sundt clip graft (Codman, Raynham, Massachusetts), which was developed in partnership with Dr George Kees. This device is a vessel-encircling Teflon or Dacron graft loaded on a circular metallic spring initially designed to repair injuries to vessel walls during intracranial aneurysm surgery,
1
which was not an uncommon complication resulting from the use of contemporary aneurysm clips.
2
When used for this purpose, the clip graft has demonstrated both safety and efficacy in a modern series of surgical treatment of intracranial aneurysm.
3
An additional application of the clip graft is the direct clipping of aneurysms, particularly side-wall aneurysms, though Dr Sundt recognized that the potential to occlude perforating arteries adjacent to the aneurysm neck would limit the general use of the clip graft for aneurysm clipping.
2
In the following video, we present archival footage of Dr Sundt utilizing the Sundt clip graft during intracranial aneurysm surgery. The 3 cases are of the treatment of posterior communicating, middle cerebral, and anterior communicating artery aneurysms and depict the potential applications of the clip graft during aneurysm surgery. We also present footage of animal experiments Dr Sundt performed to validate the use of the clip graft. This footage likely represents some of the first microscopic neurosurgical recordings ever made.
The patients consented to the procedure and to presentation of video recordings at the time of initial surgery.
Image of Sundt at 0:11, Reproduced with permission from the American Association of Neurological Surgeons, 5550 Meadowbrook Dr, Rolling Meadows, IL 60008. Figures at 2:26 and 2:28, from Park PJ, Meyer FB, The Sundt clip graft, Neurosurgery, 2010;66(6 suppl operative):300-305, by permission of the Congress of Neurological Surgeons. Figure at 2:35, ©2009 Mayo, Clingman. Used with permission.
Microscopic coupled-channel calculation of proton and alpha inelastic scattering to the $4^+_1$ and $4^+_2$ states of $^{24}\textrm{Mg}$
Authors: Kanada-En’yo Yoshiko , Ogata Kazuyuki 
Published: March 2021

Abstract
The triaxial and hexadecapole deformations of the $K^\pi=0^+$ and $K^\pi=2^+$ bands of $^{24}$Mg have been investigated by the inelastic scatterings of various probes, including electrons, protons, and alpha($\alpha$) particles, for a prolonged time. However, it has been challenging to explain the unique properties of the scatterings observed for the $4^+_1$ state through reaction calculations. This paper investigates the structure and transition properties of the $K^\pi=0^+$ and $K^\pi=2^+$ bands of $^{24}$Mg employing the microscopic structure and reaction calculations via inelastic proton and $\alpha$ scattering. In particular, the $E4$ transitions to the $4^+_1$ and $4^+_2$ states are reexamined. The structure of $^{24}$Mg was calculated employing the variation after the parity and total angular momentum projections in the framework of the antisymmetrized molecular dynamics (AMD). The inelastic proton and $\alpha$ reactions were calculated by the microscopic coupled-channel (MCC) approach by folding the Melbourne $g$-matrix $NN$ interaction with the AMD densities of $^{24}$Mg. Reasonable results were obtained on the properties of the structure, including the energy spectra and $E2$ and $E4$ transitions of the $K^\pi=0^+$ and $K^\pi=2^+$ bands owing to the enhanced collectivity of triaxial deformation. The MCC+AMD calculation successfully reproduced the angular distributions of the $4^+_1$ and $4^+_2$ cross sections of proton scattering at incident energies of $E_p=40$–100 MeV and $\alpha$ scattering at $E_\alpha=100$–400 MeV. This is the first microscopic calculation to describe the unique properties of the $0^+_1\to 4^+_1$ transition. In the inelastic scattering to the $4^+_1$ state, the dominant two-step process of the $0^+_1\to 2^+_1\to 4^+_1$ transitions and the deconstructive interference in the weak one-step process were essential.
Exploratory Analysis of Physical Therapy Process of Care and Psychosocial Impact of the COVID-19 Pandemic on Physical Therapists
Authors: Tiwari Devashish , Naidoo Keshrie , Chatiwala Naseem , Bartlo Pamela L , Triola Allison , Ong Brandon , Gore Shweta 
Published: March 2021

Abstract

Objective
The purpose of this study was to investigate the physical therapy process of care, clinical practices, and the self-reported psychosocial impact of working during the 2020 pandemic on physical therapists and physical therapist assistants.

Methods
An electronic survey including closed and open-ended questions was distributed to physical therapists employed in a range of health care settings across the United States.

Results
Physical therapy use and process of care varied across settings. Feasibility of performing an assessment was the main driver for selection of outcome measures. Interventions were mainly geared toward improving respiratory function and deconditioning. Prone patient positioning, now commonplace, was used infrequently by therapists in acute care prior to coronavirus disease 2019 (COVID-19). Similarly, outpatient and home care settings noted an increase in the use of respiratory-driven interventions such as incentive spirometry and breathing exercises. Qualitative data analysis revealed both physical barriers (personal protective equipment [PPE]) and social barriers to care. Therapists noted challenges in discharge planning and patient/family education due to the impact of social isolation. They also noted difficulty maintaining productivity standards because of additional time spent in changing PPE and following safety measures. Participants dealt with rapid changes in their role, changing productivity standards, and needing to increase their knowledge in a short amount of time.

Conclusion
Physical therapy use varied widely across settings. Despite some concern for personal health, respondents felt that the COVID-19 pandemic increased a sense of togetherness among team members and promoted greater appreciation for life and work.

Impact
This exploration of the process of care and current clinical practices across settings provides important knowledge about the role of physical therapists and physical therapist assistants in the care of patients with COVID-19. Gaining an understanding of the psychosocial impact of the pandemic among therapists could assist in creating solutions to better support clinicians’ well-being.
Mask is a must: the need of protection and safety against COVID-19
Authors: Punsalan Mairre Louie D , Salunga Angelyn T 
Published: March 2021

Abstract
As the strict quarantine measures ease and the availability of vaccines, reports have proposed that people of varying ages are now less likely to wear mask despite its added protection and safety against COVID-19. In a recent short article published, it was found out that older age groups may less likely to wear face masks in comparison with the younger ones. The importance of face masks must always be geared toward better health outcomes and safety precautions of wearing face mask as the world battles with the pandemic. With varying studies, face mask can be an essential means to mitigate the spread of COVID-19.