bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Hasil Belajar Mata Pelajaran Produktif dan Partisipasi Ekstrakulikuler Terhadap Kesiapan Berwirausaha Siswa Kelas XII SMK Negeri 6 Malang
Authors: Oktapian Andi 
Published: July 2021

Abstrak: Penelitian ini bertujuan untuk mendeskripsikan pengaruh hasil belajar mata pelajaran produktif, dan partisipasi ekstrakulikuler terhadap kesiapan berwirausaha siswa kelas XII SMK Negeri 6 Malang. Penelitian ini menggunakan metode penelitian ex post facto dan pendekatan kuantitatif dengan menggunakan instrumen berupa kuesioner dan dokumentasi. Data penelitian berupa angket siswa dan hasil belajar mata pelajaran produktif semester 4. Diolah dengan menggunakan analisis statistik, uji asumsi klasik dan uji hipotesis untuk membuktikan hipotesis adanya pengaruh hasil belajar mata pelajaran produktif, dan partisipasi ekstrakulikuler terhadap kesiapan berwirausaha. Anggota populasi siswa kelas XII berjumlah 93 siswa. Sampel diambil dengan teknik simple random sampling sehingga setiap anggota populasi memiliki peluang yang sama untk menjadi sampel penelitian, berjumlah 75 siswa. Hasil penelitian disimpulkan bahwa ada pengaruh yang signifikan antara hasil belajar mata pelajaran produktif, dan partisipasi ekstrakulikuler terhadap kesiapan berwirausaha siswa kelas XII SMK Negeri 6 Malang. Kata kunci: hasil belajar, mata pelajaran produktif, partisipasi ekstrakulikuler, kesiapan berwirausaha
Penggunaan Media pada Pembelajaran Daring Tema 7 “Peristiwa dalam Kehidupan” Kelas V di SDN Sumbersari 1 Malang
Authors: Sholichah Mar’atus , Winahyu Sri Estu , Sukamti Sukamti 
Published: July 2021

Abstract: Learning media is one of the important components in learning. Before using the media the teacher must pay attention to the planning and criteria for selecting a good media. So that the desired learning objectives can be achieved optimally. However, not all teachers plan, select, and use learning media properly and appropriately. This study aims to describe the planning, selection, and use of media as well as the obstacles experienced in implementing the use of media in online learning Theme 7 "Events in Life" Fifth Grade at State Elementary School Sumbersari 1 Malang. This study uses a descriptive qualitative approach. Collecting data using interview, observation, and documentation techniques. Based on the results of the study, it was found that the teacher did not do the media planning themselves but used the media planning listed in the lesson plans which were arranged in one cluster. In choosing the media, it is different from the media that has been planned. This is because the media planned in the lesson plans cannot be applied 100 percent the same, adjusting to the conditions of each school. There are media that are not in accordance with the learning objectives. The use of media has implemented the steps of using media well. The obstacle experienced is that there are students who do not open the media sent by the teacher. As well as the limited ability of teachers in making technology-based media.
Abstrak: Media pembelajaran merupakan salah satu komponen penting dalam pembelajaran. Sebelum menggunakan media guru harus memperhatikan perencanaan dan kriteria pemilihan media yang baik. Sehingga tujuan pembelajaran yang diinginkan dapat tercapai dengan optimal. Namun, tidak semua guru melakukan perencanaan, pemilihan, dan penggunaan media pembelajaran dengan baik dan sesuai. Penelitian ini bertujuan untuk mendeskripsikan perencanaan, pemilihan, dan penggunaan media serta kendala yang dialami dalam penerapan penggunaan media pada pembelajaran daring Tema 7 “Peristiwa dalam Kehidupan” kelas V di SDN Sumbersari 1 Malang. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Pengumpulan data menggunakan teknik wawancara, observasi, dan dokumentasi. Berdasarkan hasil penelitian diperoleh bahwa guru tidak melakukan perencanaan media sendiri melainkan menggunakan perencanaan media yang tertera pada dokumen RPP yang disusun dalam satu gugus. Dalam memilih media, berbeda dengan media yang sudah direncanakan. Hal ini dikarenakan media yang direncanakan dalam RPP tidak bisa diterapkan 100 persen sama, menyesuaikan dengan kondisi sekolah masing-masing. Terdapat media yang tidak sesuai dengan tujuan pembelajaran. Penggunaan media sudah menerapkan langkah-langkah penggunaan media dengan baik. Kendala yang dialami yaitu terdapat siswa yang tidak membuka media yang dikirimkan oleh guru. Serta keterbatasan kemampuan guru dalam membuat media berbasis teknologi.
Psychometric Properties of the Difficulties in Emotion Regulation Scale Brief Form (Ders-16): in Group of Iranian Adolescents
Authors: Fallahi Vahid , Narimani Mohammad , Atadokht Akbar 
Published: July 2021

Introduction: Given the importance of the scale of difficulty in emotion regulation, in measuring the ability to regulate emotion in adolescents and adults, which is widely used in research and clinical settings, the purpose of this study was to investigate the psychometric properties of short form of difficulty in emotion regulation (DERS-16) in group of Iranian adolescents.
Methods: The method of the present study was a survey in which the statistical population consisted of all 16 to 18 years old male secondary school students in Ardabil City in the 2019-2020 academic year (N = 21756). Among which 409 individuals were selected by cluster random sampling and individually responded to the DERS-16 & NEO-FF-R. To analyze the data internal consistency coefficient, divergent validity and exploratory and confirmatory factor analysis were used. Data were analyzed using SPSS version 16 and LISREL 8.8 software.
Results: The results of internal coefficient showed that this scale had a good reliability. Fit indices of confirmatory factor analysis also showed appropriate scale validity (CFI = 0.99, RFI = 0.98, NNFI = 0.99, and RMSEA = 0.048).
Conclusion: Findings indicate that the Persian version of this scale is a good tool for measuring the difficulty in regulating emotion and can be used to assess the difficulty in regulating emotion in adolescents and adults.
DOMESTIC WORK OR WORKING AT INFORMAL SECTOR: A STUDY OF WOMEN IN SEMNAN
Authors: Alirezanejad Soheila 
Published: July 2021

Purpose: Present study aims to seek the reason why some women are working in the informal sector while the payment is meagre and there is neither insurance nor any bonus.
Methodology: Answering the above question, a mixed-method was designed (Grounded theory and survey). Data was gathered by using semi-structured interviews and questionnaires. Due to research limitations, quota sampling was used. During this research, 14 interviews were conducted with employed women in the informal sector. Discussions were open-ended. In addition, 180 questionnaires were filled out by participants.
Main findings: Findings indicated that these women have to choose between unpaid, endless domestic work and complex low-wage employment in the informal sector. They have to work because they want to have autonomy, and they feel a responsibility towards their family, especially their children. Despite the low payment, their job brought about a sort of empowerment for them. Working in the informal sector let them support their family and achieve emotional capital. If they do not work in the informal sector, they have to work at home as an unpaid worker of their family.
Application of the study: Women's employment in the informal sector has increased quickly during recent years, so examining their working conditions, especially from the point of view of salaries and benefits, can be effective in improving their living conditions
Novelty/Originality: The reason for the increase in demand for work in the informal sector, especially by women, is an issue that has never been explicitly addressed.
Deposition of Molybdenum Oxide Thin Films for Flexible Biodegradable Electronics
Authors: Hondovska Anna Serhiivna , Didus Roman Ihorovych , Lapshuda Vladyslav Anatoliiovych , Yashchenko Olha Vasylivna 
Published: July 2021

With its unprecedented properties over conventional rigid platforms, flexible electronics have been a significant research topic in the last decade, offering a broad range of applications from bendable display, flexible solarenergy systems, to soft implantable-devices for health monitoring. Flexible electronics is a disruptive science that requires a high level of multi-disciplinary research, including chemistry, physics, material science, electronic and electrical engineering, mechanical engineering, computing science, biomedical engineering. The deep cross-integrate of it with other key subjects such as artificial intelligence, material science, Internet of things, space science, health science, energy science and data science, breaks through the intrinsic limitations of convention silicon electronics and affords unprecedented opportunities for relative industries involving integrated circuit, new and renewable.
One way to reduce the cost of photoconverters is to use transition metal oxide, which is characterized by better solar energy conversion efficiency. is one of the promising candidates due to its nontoxicity, deep electronic state and relative lower vaporization temperature, which can easily deposited in vacuum. In contrast, the other transition metal oxides need relative higher evaporation temperature to deposit the film. The conventional and common fabrication methods for are thermal evaporation or sputtering under vacuum. This work presents molybdenum oxide films grown on nanocellulose. Molybdenum oxide thin films were grown by reactive ion beam sputtering on UVN-75R equipment. Measurements of thin film transparency spectra and the effect of bending on the transparency value were measured using a 4802 UV/VIS Double Beam Spectrophotometer. The energy-dispersion X-ray spectrum showed no impurities. The chemical composition of molybdenum oxide thin films was studied on the basis of energy-dispersion analysis, in which the characteristic X-ray radiation of the sample surface under the action of accelerated electron irradiation was recorded. For this purpose, a scanning electron microscope REM-106U in the mode of elemental microanalysis was used.
The films show high transparency in the visible spectrum, as well as a low influence of bending on the transparency in the ultraviolet spectrum. Bending of the manufactured samples reduces the amount of transparency. Increasing the deposition temperature of the films has the same effect as bending. Combining the excellent electrical properties of and the high flexibility and transparency of nanocellulose, an excellent replacement for silicon heterostructures has been demonstrated.
Novel PhoH-encoding vibriophages with lytic activity against environmental Vibrio strains
Authors: Maina Alice Nyambura , Mwaura Francis B. , Jumba Miriam , Kieft Kristopher , El-Din Hanzada T. Nour , Aziz Ramy K. 
Published: July 2021

Abstract
Cholera is a devastating diarrheal disease that accounts for more than 10% of children’s lives worldwide, but its treatment is hampered by a rise in antibiotic resistance. One promising alternative to antibiotic therapy is the use of bacteriophages to treat antibiotic-resistant cholera infections, and control Vibrio cholera in clinical cases and in the environment, respectively. Here, we report four novel, closely related environmental myoviruses, VP4, VP6, VP18, and VP24, which we isolated from two environmental toxigenic Vibrio cholerae strains from river Kuja and Usenge beach in Kenya. High-throughput sequencing followed by bioinformatics analysis indicated that the genomes of the four bacteriophages have closely related sequences, with sizes of 148,180 bp, 148,181 bp, 148,179 bp, and 148,179 bp, and a G + C content of 36.4%. The four genomes carry the phoH gene, which is overrepresented in marine cyanophages. The isolated phages displayed a lytic activity against 15 environmental, as well as one clinical, Vibrio cholerae strains. Thus, these novel lytic vibriophages represent potential biocontrol candidates for water decontamination against pathogenic Vibrio cholerae and ought to be considered for future studies of phage therapy.
COVID-19 in-hospital mortality of a secondary care center of Mexico City in a marginated area during the first months of the Mexican epidemic
Authors: Alanís-Naranjo José Martín , Anguiano-Álvarez Víctor Manuel , Hammeken-Larrondo Eduardo Federico 
Published: July 2021

Abstract
Introduction: Low socioeconomic conditions and hospital saturation have been associated with higher mortality rates in hospitalized patients with COVID-19. Mexico City has become the country’s highest death toll. Iztapalapa is the district with the highest population density and marginalization in Mexico City. Most of the information on COVID-19 in-hospital mortality in Mexico comes from intensive care units or tertiary hospitals without considering the level of income. Data regarding hospital mortality in care centers with low availability of intensive care beds has not been explored.Material and methods: A retrospective cohort study in consecutive patients with COVID-19 hospitalized managed outside the intensive care unit in a secondary care center in Mexico City from April 1st, 2020, to May 31st, 2020. Analysis was performed between subgroups with a p-value <0.05 considered statistically significant.Results: A total of 164 patients were recruited; the median age was 52.5 years (IQR 44 - 64.5), 68% were males, 48.7% were obese, and 59.7% had comorbidities. Among those patients, 67% required mechanical ventilation and 32.3% vasopressor support. In this population, 52 recovered (31.7%) and 112 died (68.3%). The main risk factors associated with death were male sex, age > 50 years, diabetes, severe pneumonia on admission, PORT / PSI > 91, SMART-COP > 5, SCAP score > 10, dyspnea on admission, fever during hospitalization [p <0.05] and the administration of intravenous antibiotics [RR 3.45, 95% CI 1.69-7.06, p <0.001].Conclusion: In this study, we found higher in-hospital mortality compared to previous reports. We suggest that the administration of intravenous antibiotics could impact patient survival for the risk of developing hospital-acquired infections.
American Older Adults in COVID-19 Times: Vulnerability Types, Aging Attitudes and Emotional Responses
Authors: Fu Mingqi , Guo Jing , Chen Xi , Zhang Qilin 
Published: July 2021

Abstract
Background: The Coronavirus disease aroused challenges to the emotional well-being of vulnerable older adults in hard-hit areas. This study investigates different vulnerability types among American older adults and how modes of vulnerability are associated with aging attitudes and emotional responses. Methods: This is a cross-sectional study with 2003 American respondents aged over 50 from the Health and Retirement survey. Emotional responses and aging attitudes were assessed with I-PANAS-SF and ATOT. The vulnerability was evaluated by 16 kinds of difficulties people had during the pandemic. We used Latent class analysis to identify the vulnerability pattern of individuals. Hierarchical linear regressions were further used to examine the relationship between vulnerability type and positive aging attitudes with positive and negative emotional responses. Results: We detected three vulnerability types among American older adults: the slight vulnerability (72%), the healthcare use vulnerability (19%), and the dual vulnerabilities (9%). No significant difference in positive emotions was found between vulnerability types. However, more negative emotions were found among older adults with healthcare use vulnerability (B=0.746, SE=0.759) and dual vulnerabilities (B=1.186, SE=0.274) than those with slight vulnerability. Positive aging attitudes associate with more positive emotions (B=0.266, SE=0.017) but less negative emotions (B=-0.183, SE=0.016) and had significant moderation effects on the relationship between vulnerability types and negative emotional responses (B=-0.118, SE=0.045). Conclusion: Older adults' emotional well-being should not be neglected as they deserve the support of prevention and intervention strategies, in particular when they have vulnerabilities in healthcare use and financial sustainment. Female, non-white races, and those aged below 65, been uncoupled, less educated, and with ADL difficulties should prioritize.
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia
Authors: Fisher-Wellman Kelsey H. , Hagen James T , Kassai Miki , Kao Li-Pin , Nelson Margaret , McLaughlin Kelsey , Coalson Hannah , Fox Todd , Tan Su-Fern , Feith David , Kester Mark , Loughran Thomas , Claxton David , Cabot Myles 
Published: July 2021

Abstract
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actions are often supplanted by resistance. In the present work we utilized HL-60 human leukemia cells and a VCR-resistant counterpart, HL-60/VCR, as a model to determine potential interplay between SL metabolism and mitochondrial bioenergetics supportive of multidrug resistance (MDR). Relative to wild-type cells, HL-60/VCR presented with global alterations in SL composition, typified by upregulated expression of sphingosine kinase (SPHK1), which catalyzes formation of sphingosine 1-phosphate (S1P), glucosylceramide synthase (GCS), which catalyzes formation of glucosylceramides (GC), and acid ceramidase, responsible for ceramide hydrolysis. In support of these changes, VCR resistance was also characterized by increases in S1P, several molecular species of ceramide and GC, and changes in sphingomyelin (SM) molecular species. With respect to mitochondria, despite increased basal respiration in HL-60/VCR cells, direct interrogation of the mitochondrial network revealed intrinsic respiratory complex insufficiency, largely localized to complex I (CI). Importantly, forced ceramide accumulation in wild-type cells phenocopied the respiratory insufficiency observed in HL-60/VCR, and co-targeting SL metabolism and CI induced synergistic cytotoxicity in HL-60/VCR cells, as well as in other MDR leukemia models. Together, these data underscore the intimate connection between cellular sphingolipids and mitochondrial metabolism and suggest that pharmacological intervention across both pathways may represent a novel treatment strategy against MDR.
Impulsive Lifestyle Counselling Versus Treatment as Usual to Reduce Offending in People with Co-Occurring Antisocial Personality Disorder and Substance Use Disorder: A Post Hoc Analysis - BMC
Authors: Hesse Morten , Thylstrup Birgitte 
Published: July 2021

Abstract
Objectives: To assess the impact of a psychoeducation for antisocial personality disorder on offending after randomization to treatment.Design: Multicentre, superiority, non-blinded randomized controlled trial. Random assignment was conducted in blocks of varying sizes at a central randomization centre.Setting: Nine outpatient uptake areas in Denmark.Participants: One hundred and seventy six patients with antisocial personality disorder in treatment for substance use disorders were randomized to treatment as usual or ILC (n=80; n=96). A total of 165 patients could be linked to criminal records collected between randomization and November 2019 (n=91; n=74).Intervention: The Impulsive Lifestyle Counselling program (ILC), is a brief psycho-educational program targeting antisocial behavior. The trial was conducted between January of 2012 and June 2014, and participants were tracked until December 2018, migration, or death, whichever occurred first. Outcomes: Number of offences in the 12 months following trial randomization from official national registers.Results: The mean number of offences was 2.76 in the TAU group (95% Poisson confidence interval [CI]=2.39, 3.16) and 1.87 in the ILC group (CI=0.97, 1.43). Negative binomial regression was used to assess number of convictions within the first year; violent, property, driving under the influence, and drug-related convictions. In both adjusted and unadjusted analyses, random assignment to ILC was associated with a lower number of total (incremental risk ration [IRR]=0.43, p=.013; adjusted IRR=0.33, p<.001), violent (IRR=0.19, p=.001; adjusted IRR=0.16, p=.018). Results were not significant for driving under the influence (unadjusted IRR=0.60, p=.371; adjusted IRR=0.87, p=.521), or drug offences (unadjusted IRR =1.06, p=.905; adjusted IRR=0.50, p=.180).Conclusions: The ILC program shows promise in reducing offending behavior in people with comorbid substance use and antisocial personality disorder.Trial registration: ISRCTN registry, ISRCTN67266318, 17/7/2012, https://doi.org/10.1186/ISRCTN67266318.
Role and mechanism of miR-130a-3p in the chemosensitivity of retinoblastoma cells to vincristine
Authors: Lu Xiulan , Tu Huifang , Tang Dongrun , Huang Xiaoming , Sun Fengyuan 
Published: July 2021

Abstract
Purpose

Chemoresistance remains the primary obstacle threatening the prognosis of retinoblastoma (RB). microRNAs (miRNAs) are acknowledged as critical regulator of drug resistance. This study explored the molecular mechanism of miR-130a-3p affecting the chemosensitivity of RB to vincristine (VCR).
Methods

miR-130a-3p expression of VCR-sensitive and VCR-resistant RB tissues was detected using RT-qPCR. VCR-resistant RB cell line Y79/VCR was induced. miR-130a-3p expression of Y79/VCR cell line and its corresponding parental cell line was detected. Y79/VCR cells were subjected to miR-130a-3p overexpression treatment. The cell proliferation was measured using MTT assay, and the IC50 value and drug resistance index were examined using CCK-8 assay. The targeting relationship between miR-130a-3p and PAX6 was predicted through bioinformatics analysis and verified using dual-luciferase assay. Functional rescue experiments were conducted to confirm the role of PAX6 in chemosensitivity of RB cells. The effect of miR-130a-3p on tumorigenesis and VCR sensitivity was observed in vivo.
Results

miR-130a-3p was downregulated in VCR-resistant RB tissues and cells. Overexpression of miR-130a-3p repressed the proliferation of VCR-resistant RB cells and enhanced chemosensitivity. miR-130a-3p targeted PAX6 expression. Overexpression of PAX6 reversed the effect of miR-130a-3p on chemosensitivity of RB. Overexpression of miR-130a-3p suppressed tumor growth and reduced VCR resistance in vivo.
Conclusion

miR-130a-3p enhanced the chemosensitivity of RB cells to VCR by targeting PAX6 expression.
Diffuse Alveolar Hemorrhage (DAH) Associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Case Report
Authors: Wali Haytham , Tabb Deanne , Baloch Saeed A. 
Published: July 2021

Abstract
Diffuse alveolar hemorrhage (DAH) is a rare syndrome resulting from the accumulation of intra-alveolar red blood cells (RBCs) originating most often from the alveolar capillaries and, less frequently, from precapillary arterioles or postcapillary venules. The causes of DAH can be divided into infectious and noninfectious. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has not been previously identified in humans, and it is responsible for the coronavirus disease-19 (COVID-19) infection. The long-term complications of COVID-19 are not entirely known and are still being investigated. Here, we present a case of DAH that is believed to be a consequence of COVID-19 infection.