bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic potential of Cymbopogon schoenanthus (L.) developed into nanoparticle technology
Authors: Chabib Lutfi , Hidayat Adnan Muhammad Uno J , Trianloka A.M. Bagas , Pangestu Muhammad Iqbal , Suryani Arman , Yulianto  
Published: July 2021

Introduction: One of plants that may have therapeutic potential is the Cymbopogon schoenanthus (L.) Spreng, also known as camel grass.
Aim: This review aims to investigate and gather comprehensive information about camel grass plants and their potential to be developed into a nanotechnology drug delivery system.
Methods: This review examined a variety of online literature.
Results: It was found that camel grass contains essential oil such as piperitone. Piperitone is efficacious as an antioxidant, antimicrobial and anti-inflammatory, in addition to other properties . The development of camel grass essential oil into lipid-based nanotechnology preparations can improve its bioavailability, solubility, and stability, thereby improving its potential effectiveness.
Analysis of white pepper essential oil components using gas chromatography-mass spectroscopy
Authors: Purwaniati  , Permana Gilang Eka , Pamudjo Indro 
Published: July 2021

Introduction: White pepper is an important commodity used to produce essential oils. Differences in the oil components are determined by which region the peppers used were sourced from.
Aims: The aim of this study was to analyse the components of the essential oils produced by white peppers from different regions and to examine the specificity of these peppers.
Methods: This analysis was carried out using the chromatography gas – mass spectroscopy (GC-MS) method on essential oil samples made from peppers obtained from the Java, Sumatera, Kalimantan, and Sulawesi Islands.
Results: The results showed that white pepper essential oil contains 22 components, and that α-pinene, ꞵ–pinene, ∆-carene, sabinene, dl-limonene, and caryophyllene were major compounds within the oils. Furthermore, it showed that α-pinene, sabinene, and caryophyllene compounds were most found in samples from the Kalimantan, Sumatra, and Sulawesi Islands respectively.Meanwhile, those from Java Island contained ꞵ – pinene, ∆-carene, and caryophyllene in similar quantities.
Formulation and physical properties of lotion Kalakai root ethanol extract (Stenochlaena palustris Bedd)
Authors: Adawiyah Rabiatul , Apriliyanti Riska , Umaternate Agustinawati 
Published: July 2021

Aim: To determine the physical (organoleptic, homogeneity, pH, dispersibility and adhesion) properties of the ethanol extract of Kalakai root lotion with a concentration of 1%, 2% and 3%.
Methods: This study used the maceration method that was carried out by testing the physical properties of the lotion preparation with three concentrations, namely 1%, 2% and 3% using one type, namely the M/A type.
Results: It was found that at a concentration of 3% it was a formula for the ethanol extract of Kalakai root that met the quality parameters of the good physical properties of the lotion.
Conclusion: Kalakai root extract concentration influenced the physical properties of the lotion preparation tested. The higher the kalakai root extract concentration, to a concentration of 3%, did not affect the pH value or homogeneity, but the kalakai root extract lotion preparation had higher results for the spreadability and adhesion.
Medicine management in districts and primary health care centres (PHC) in the national health insurance (JKN) programme
Authors: Raharni  , Sasanti Rini , Yuniar Yuyun 
Published: July 2021

Aim: This study aimed to identify medicine management in district health offices and primary health care centres (PHCs) after the national health insurance (JKN) programme implementation.
Methods: A cross-sectional study was carried out by collecting documents related to medication management and in-depth interviews with the head of the PHC officials and JKN medicine management officers at the PHC in four provinces of Indonesia.
Results: The results showed no regional policies related to medicine management; all policies were based on central policies. Medicine management in districts follows the procurement planning suggested by PHCs, which relies on disease patterns. Medicine procurement at PHCs is done by e-purchasing using an e-catalog. Medicines above IDR 200 million are purchased through catalogs provided by the procurement service unit (ULP), and those under IDR 200 million are obtained through a direct appointment.
Conclusion: The storage of medicine requires more space and air humidity controlling. The reporting and monitoring of medications e-logistic system are based on 20 indicators and have not been carried out regularly. It is necessary to improve reporting and monitoring systems.
Drug interactions in patients with hypertension at Persahabatan hospital in 2015
Authors: Islam Zainul , Vitasari Atika , Ridwan Muhammad Arif 
Published: July 2021

Introduction: Hypertensive disease can cause various complications, such as cardiovascular disease, stroke, diabetes mellitus, and kidney failure. To overcome these complications, patients are given polypharmacy therapy, which can potentially lead to drug interactions.
Aim: The purpose of this study was to determine the potential incidence of drug interactions in hypertensive inpatients at the Persahabatan Hospital in 2015.
Methods: The research is a descriptive study with retrospective data by purposive sampling technique using secondary data, medical records of hypertensive inpatients. The study of drug interactions was conducted theoretically, based on a literature study using Drug Interaction Facts 2014.
Results: The results showed out of 174 hypertensive patients, 141 (81.0%) had potential drug interactions, with a total of 1444 cases. The highest drug interactions were at three levels of significance in 383 cases (26.5%), with 554 cases (38.4%) of pharmacodynamic mechanisms.
Hypoglycemic activity test on smooth pigweed (Ammaranthus Hybridus L) leaf water extract on male Wistar rats
Authors: Rindarwati Asti Yunia 
Published: July 2021

Introduction: Type 2 diabetes mellitus consists of an array of dysfunction characterized by hyperglycemia. The activity of smooth pigweed (Amaranthus hybridus L.) leaves water extract on male Wistar rats.
Aims: This research was started by supplying simplicia, making smooth pigweed leaves water extract, and testing the hypoglycemic activity of smooth pigweed leaves water extract on male Wistar rats.
Methods: The glucose tolerance method was used to determine the hypoglycemic activity of smooth pigweed leaves water extract. Male white rats were divided into five groups of six rats each: a positive control group (0.5% of tragacanth suspension), a comparison group (Diabinese suspension at a dose of 22.5 mg/kg body weight (bw)), and three test groups at doses of 50 mg/kg bw, 100 mg/kg bw, and 150 mg/kg bw.
Results and conclusions: The most significant hypoglycemic activity was seen with the dose of 150 mg/kg bw in comparison with the control group at 90 minutes.
Systemic Risk and Dynamics of Stock Prices: A Short and Long Run Analysis from Nigeria Capital Market
Authors: Charles Fortune Bella , Okoro Charles Ugochukwu 
Published: July 2021

This study examined the effect of systemic risk on the dynamics of stock prices in Nigeria capital market. The objective was to investigate the dynamic effect of systemic risk on stock prices traded on the floor of Nigeria stock exchange. Time series data was sourced from Central Bank of Nigeria Statistical Bulletin from 1990-2017. Stock prices were modeled as the function of prices risk, liquidity risk, interest rate risk and exchange rate risk. Multiple regression with ordinary least square properties of co-integration was used to examine the relationship between the dependent and the independent variables. The study found price and liquidity risk have positive effect on stock price while interest rate and exchange rate risk have negative effect on stock prices of equities traded on Nigeria stock exchange. It concludes that systemic risk has significant effect on stock prices and recommends, among others, that the management of the capital market should ensure that the operating environment is risk minimum to ensure appreciable stock prices by developing strategies and policies aim at managing the systematic risk in the operating environment and engage a regular environmental impact assessment on systemic risk, to avert it’s negative effect on stock prices.
Recrutamento de animais sésseis e sedentários em substrato artificial na área portuária do Recife – PE, com enfoque para a bioinvasão
Authors: Melo Arthur V. O. M. , Schwamborn Ralf , Farrapeira Cristiane M. R. 
Published: July 2021

RESUMO
O Porto do Recife recebe uma grande quantidade de navios de vários tipos e de muitas partes do mundo, podendo trazer espécies exóticas incrustadas no casco ou em água de lastro. O objetivo do presente estudo foi registrar e analisar os padrões de recrutamento de espécies bentônicas sésseis, assim como investigar uma possivel introdução de espécies bentônicas exóticas e criptogênicas em uma área portuária com grande fluxo de navios. Utilizaram-se placas de metal galvanizado para estudo do recrutamento de animais sésseis e sedentários em três pontos amostrais no porto, com três réplicas cada, totalizando nove pontos, durante seis meses (outubro de 2010 a março de 2011), considerado como período seco. As placas de recrutamento foram retiradas a cada 30 dias durante seis meses. As principais espécies de acordo com a área de cobertura foram Mytella charruana (72%) e Amphibalanus improvisus (22%) e espaços vazios (7,5%). Não houve diferença significativa quando comparadas as três estações no porto do Recife, sendo encontradas diferenças quando comparadas os dados das áreas de cobertura das espécies mais abundantes no recrutamento. Foram elas: Clytia gracilis, Obelia dichotoma, M. charruana e A. improvisus.

ABSTRACT
The Port of Recife receives a large number of vessels of various types and from many parts of the world, and can bring exotic species encrusted hull or in ballast water. The aim of this study was to record and analyze the patterns of recruitment of sessile benthic species, as well as investigating a possible introduction of exotic and cryptogenic benthic species in a port area with great flow vessels. We used galvanized metal plates to study the recruitment of sessile and sedentary animals at three stations in the harbor, with three replicas each, totaling nine points, six months (October 2010 to March 2011), considered the dry . The plates recruitment were taken every 30 days for six months. The main species according to coverage area were Mytella charruana (72%) and Amphibalanus improvisus (22%) and voids (7.5%). There was no significant difference when comparing the three stations in the Port of Recife, differences were found when comparing the coverage areas of most abundant species in recruitment. They were: Clytia gracilis, Obelia dichotoma, M. charruana and A. improvisus.
Preparar al maestro para el cambio educativo
Authors: Fabelo Lesbia Gertrudis Cánovas 
Published: July 2021

RESUMEN
Existe una toma de conciencia en relación con la necesidad de producir cambios en la educación; pero no está suficientemente claro por qué y para qué cambiar, qué, cómo y quién debe cambiar. Aparece siempre en el horizonte la amenaza de nuevos dogmatismos, y sobre todo de ejercicios tradicionales de cambio que son más deseos que realidades.
Repensar la formación de los maestros implica pensar en los contenidos de la formación, en los que enseñará, cómo los transmitirá, (incorporando las TIC), y el tipo de prácticas para trabajar en el aula, con la familia y la gestión en la escuela, pero también cómo debe ser el proceso formativo para que estén en capacidad de promover el cambio educativo.
El modelo de formación debe poner el énfasis en que el aprendizaje ocurre en una relación entre el profesor y los estudiantes, donde intervienen dos aspectos cruciales, uno es cognitivo: el conocimiento, dominio de la materia que enseña, y el otro es emocional: la capacidad para poder interpretar el mundo interno de los alumnos.
El Proyecto Con infinito amor pone el énfasis en propiciar la participación de los estudiantes, motivarlos de manera que sepan reflexionar y orientarse acertadamente ante su realidad.

ABSTRACT
There is a growing awareness of the need to bring about change in education, but it is not sufficiently clear why and what to change, what, how and who should change. The threat of new dogmatisms always appears on the horizon, and above all of traditional exercises of change that are more desires than realities.
Rethinking teacher training implies thinking about the contents of the training, what they will teach, how they will transmit them (incorporating ICT), and the type of practices to work in the classroom, with the family and school management, but also what the training process should be like so that they are able to promote educational change.
The training model should emphasize that learning occurs in a relationship between the teacher and the students, where two crucial aspects are involved, one is cognitive: knowledge, mastery of the subject taught, and the other is emotional: the ability to interpret the inner world of the students.
The Con infinito amor project emphasizes the participation of students, motivating them so that they can reflect and orient themselves correctly in the face of their reality.
Reacción acneiforme como efecto adverso del apremilast
Authors: Trujillo Angélica , Flamini Mara , Díaz Pamela , García Sandra , Aloise ítalo 
Published: July 2021

El apremilast es un fármaco inhibidor de la fosfodiesterasa-4 que modula, a nivel intracelular, la expresión de citoquinas involucradas en la patogenia inflamatoria de la psoriasis. Su uso está indicado en la psoriasis en placas moderada y severa, con buenos resultados clínicos. Los principales efectos adversos son gastrointestinales y, en menos del 2% de los pacientes, dermatológicos, con exantema y foliculitis. Se presenta el caso de un paciente de 42 años que, luego de tomar el apremilast, desarrolló lesiones faciales que correspondieron clínica e histopatológicamente a una reacción acneiforme, con evolución favorable y resolución total del cuadro posterior a la suspensión del medicamento.
Arrhythmia Termination During Radiofrequency Delivery Improves Outcomes after Catheter Ablation for Persistent and Long Standing Persistent Atrial Fibrillation
Authors: Nastasa Alexandrina , Iorgulescu Corneliu , Bogdan Stefan , Deaconu Silvia , Petre Stefan , Gondos Viviana , Dorobantu Maria , Vatasescu Radu Gabriel 
Published: July 2021

Abstract

Background
Achieving long-term successful outcomes with catheter ablation (CA) of persistent atrial fibrillation (PsAF) remains a challenge. Multiple attempts to determine effective ablation strategies besides the pulmonary veins (PV) were made but, so far, there is no agreed standard approach and no clear consensus as to which is the best one. Among the most frequently used techniques was ablation of complex atrial fractionated electrograms (CFAE) but studies showed contradictory results. The optimal procedural endpoint also needs further refinement.

Objectives
We sought to evaluate outcomes in regard to patient characteristics and procedural termination. We also aimed to assess whether continuation of antiarrythmic therapy in the blanking period (1 to 3 months after the procedure) influences long term results.

Methods
We enrolled consecutive patients with persistent and long-standing PsAF (LS-PsAF) who underwent one or more radiofrequency catheter ablations (RF CA) - pulmonary vein antral isolation (PVAI), followed by CFAE or resultant atrial tachycardia/flutter elimination, were retrospectively analyzed. Procedural objective was tachyarrhythmia (AF or resultant atrial flutters/tachycardias) termination (TT) to sinus rhythm (SR) during RF delivery. If after extensive substrate based or activation guided ablation sinus rhyhtm was not restored, conversion was performed with antiarrhythmic drugs (AAD), overdrive pacing or electrical shock. Screening for arrhythmia recurrence was performed via clinical interview and 48 hours Holter monitoring at 1,3 and 6 months and then every 6 months.

Results
The cohort included 94 patients (age 54.5±11.4, 67 (71%) males, CHADSVASc 2.3±2, 11 (12%) LS-PsAF) Acute restoration of sinus rhythm (SR) was achieved in 93.4% of the cases, 43% by ablation of CFAE or resultant atrial tachycardia/flutter(AT/AFL), 36.2% by electric cardioversion, 7.4% by chemical conversion, 3.1 % overdrive pacing, 3.7 % spontaneuous/mechanical. The long term success rate after a mean of 1.7±0.8 procedures was 59% at a mean follow-up period of 80±28 months. Freedom from AF was significantly higher when arrhythmia termination was obtained during RF delivery (p – 0.003). Short-term use of AAD in the blanking period did not lead to improved long term outcomes.

Conclusions
In patients with PsAF and LS-PsAF restoration of sinus rhyhtm during RF delivery for pulmonary vein isolation, ablation of CFAE or resultant atrial tachyarrhythmia predicts long term procedural success. Further research to determine the best strategy to achieve this outcome is necessary.
Ensuring planning of legislative activities in federal lawmaking
Authors: Веселов И.Г. , Комаров С.А. 
Published: July 2021

В статье рассматриваются вопросы планирования законодательной деятельности, роль значение юридической науки в этом процессе, выясняются причины отсутствия координации планов подготовки законопроектов на федеральном и региональном уровнях. Специально обращается внимание на необходимость координации усилий в сфере планирования законотворчества всех субъектов права законодательной инициативы на федеральном уровне и участия в этом процессе представителей науки.
The article discusses the planning of legislative activities, the role of the importance of legal science in this process, and clarifies the reasons for the lack of coordination of plans for the preparation of draft laws at the federal and regional levels. Special attention is drawn to the need to coordinate efforts in the planning of lawmaking of all subjects of the law of legislative initiative at the federal level and the participation of representatives of science in this process.
Cáncer de próstata en México: experiencia epidemiológica en el Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”
Authors: Rubí-López Bruno , Real-Cárabes Juan José , Magaña-Gutiérrez Arnoldo , Ibarra-Navarro Edgar Iván , Andrade-Pérez Fernando De Jesús , Sánchez-Mejía Pascual , Antonio-Alfaro-Alcocer Jorge 
Published: July 2021

Objetivo: Conocer la epidemiología, tratamiento y seguimiento de pacientes con cáncer de próstata en el Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”.
Materiales y métodos: Se realizó un estudio observacional, descriptivo y retrospectivo en el que se incluyeron 196 casos de pacientes con cáncer de próstata atendidos entre los años 2015 y 2020 en el Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”.
Resultados: De los 196 casos estudiados la edad media de presentación fue de 72.02 años (±8.77), el 53.5% no cuenta con nivel básico de estudios, asimismo el 87.7% no tiene un empleo formal; el índice de masa corporal (IMC) promedio fue de 25.43 kg/m2 (±3.13), siendo el tabaquismo, hipertensión y diabetes mellitus los factores de riesgo más frecuentes; una media de antígeno prostático específico (APE) antes del tratamiento de 17.59 ng/ml. De los casos atendidos, el 31.07% fueron sometidos a cirugía, 55.05% se encuentran con bloqueo hormonal y 1.02% en vigilancia. Solo se presentaron 12 casos (6.12%) de defunción asociados a cáncer de próstata con un abandono en el seguimiento del 37.75% de la población estudiada.
Limitaciones del estudio: Tamaño de muestra, estudio unicéntrico.
Valor: Estudio reciente de epidemiología de cáncer de próstata en Guadalajara, Jalisco.
Conclusiones: El cáncer de próstata en la población analizada muestra un alto grado de marginación sociocultural, así como factores de riesgo asociados que limitan la indicación de tratamientos con intención curativa; estos factores influyen en el seguimiento adecuado de los pacientes.
Reajuste de Sling TOT: ¿vale la pena?
Authors: Malizia-Reynoso Enzo , Olmedo Jose Javier , Racca María Laura , Marcos Quintero Leandro , Dellavedova Tristán , Minuzzi Susana 
Published: July 2021

Introducción: Desde su introducción, el sling TOT se instaló rápidamente como una opción segura y efectiva para el tratamiento de la incontinencia de orina de esfuerzo (IOE) femenina. Con el desarrollo del sling TOT reajustable, se adquirió la posibilidad de reacomodarlo si los resultados funcionales no hubieran sido óptimos (persistencia de IOE).
Objetivos: Analizar los resultados globales de nuestra serie de casos en términos de éxito funcional y complicaciones postquirúrgicas; y analizar la relación entre el reajuste de sling y el desarrollo de obstrucción miccional postquirúrgica, erosión de prótesis, dolor pelviano e insatisfacción con astas de prótesis.
Materiales y Métodos: Se realizó un análisis retrospectivo comparativo entre 2006 y 2016 de pacientes sometidas a colocación de sling TOT reajustable y se analizaron como subgrupo aquellas donde se hubiese realizado un reajuste de sling como segundo procedimiento. El análisis incluyó: presencia de reajuste de sling, erosión de malla, complicaciones relacionadas con astas de prótesis, desarrollo de obstrucción miccional postquirgica, y éxito funcional de la cirugía.
Resultados: Fueron seleccionadas 70 pacientes a quienes se les colocó un sling TOT reajustable (curación de IOE 84.3%; obstrucción postquirúrgica 22.8%), a 11 (15.7%) de las cuales se les realizó reajuste de prótesis por resultados funcionales adversos en las cuales la tasa de curación de IOE ascendió a 92.8% y la tasa de obstrucción post reajuste al 28.5%.
Se encontró una asociación significativa entre el reajuste y el desarrollo de dolor pelviano (36% vs 10%, p=0.02) y no existieron diferencias significativas entre los grupos en el desarrollo de obstrucción miccional postquirúrgica (p=0.23), erosión a vagina (p=0.78), erosión a vejiga (p=0.39) e insatisfacción con las astas de la prótesis (p=0.9).
Conclusión: La posibilidad de elevar el éxito funcional de una primera cirugía en pocos minutos, con anestesia local, y sin diferencias significativas en la mayoría de las complicaciones analizadas, permiten colocar este procedimiento como un complemento útil para el tratamiento de la incontinencia de orina de esfuerzo, lo que no es posible con los slings convencionales.