bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expectations, concerns and experiences of rehabilitation patients during the COVID-19 pandemic in Germany: a qualitative analysis of online forum posts
Authors: Altinok Kübra , Erdsiek Fabian , Yilmaz-Aslan Yüce , Brzoska Patrick 
Published: December 2021

Abstract
Background
The COVID-19 pandemic, as well as efforts to prevent its spread, have had a strong impact on the delivery of rehabilitative services in Germany. While several studies have addressed the impact of these developments on health service providers and COVID-19 patients, little is known about its impact on patients in need of rehabilitative treatment because of other conditions. This study aims to identify expectations, concerns and experiences of rehabilitation patients related to service delivery in this situation.

Methods
Using a qualitative study design, user posts from six German online forums between March and Mid-November 2020 were systematically searched with respect to experiences, concerns and expectations of health care users toward receiving rehabilitative treatment. We used qualitative content analysis with inductive coding as our methodological approach.

Results
Users fearing physical or psychological impairment were concerned about not receiving timely or effective treatment due to closed hospitals, reduced treatments and limited admissions. In contrast, patients more concerned about getting infected with COVID-19 worried about the effectiveness of protective measures and being denied postponement of treatment by the funding bodies. During their stay, some patients reported feeling isolated due to contact restrictions and did not feel their treatment was effective, while others reported being satisfied and praised hospitals for their efforts to ensure the safety of the patients. Many patients reported communication problems before and during their treatment, including concerns about the safety and effectiveness of their treatment, as well as financial concerns and worries about future treatments. Several users felt that their concerns were disregarded by the hospitals and the funding bodies, leaving them feeling distressed, insecure and dissatisfied.

Conclusions
While some users report only minor concerns related to the pandemic and its impact on rehabilitation, others report strong concerns relating not only to their own health and safety, but also to financial aspects and their ability to work. Many users feel ignored and disregarded, showing a strong need for more coordinated strategies and improved communication specifically with funding bodies like health insurance companies and the German pension funds.
Competitive and/or cooperative interactions of graphene-family materials and benzo[a]pyrene with pulmonary surfactant: a computational and experimental study
Authors: Yue Tongtao , Lv Rujie , Xu Dongfang , Xu Yan , Liu Lu , Dai Yanhui , Zhao Jian , Xing Baoshan 
Published: December 2021

Abstract
Background
Airborne nanoparticles can be inhaled and deposit in human alveoli, where pulmonary surfactant (PS) molecules lining at the alveolar air–water interface act as the first barrier against inhaled nanoparticles entering the body. Although considerable efforts have been devoted to elucidate the mechanisms underlying nanoparticle-PS interactions, our understanding on this important issue is limited due to the high complexity of the atmosphere, in which nanoparticles are believed to experience transformations that remarkably change the nanoparticles’ surface properties and states. By contrast with bare nanoparticles that have been extensively studied, relatively little is known about the interactions between PS and inhaled nanoparticles which already adsorb contaminants. In this combined experimental and computational effort, we investigate the joint interactions between PS and graphene-family materials (GFMs) with coexisting benzo[a]pyrene (BaP).

Results
Depending on the BaP concentration, molecular agglomeration, and graphene oxidation, different nanocomposite structures are formed via BaPs adsorption on GFMs. Upon deposition of GFMs carrying BaPs at the pulmonary surfactant (PS) layer, competition and cooperation of interactions between different components determines the interfacial processes including BaP solubilization, GFM translocation and PS perturbation. Importantly, BaPs adsorbed on GFMs are solubilized to increase BaP’s bioavailability. By contrast with graphene adhering on the PS layer to release part of adsorbed BaPs, more BaPs are released from graphene oxide, which induces a hydrophilic pore in the PS layer and shows adverse effect on the PS biophysical function. Translocation of graphene across the PS layer is facilitated by BaP adsorption through segregating it from contact with PS, while translocation of graphene oxide is suppressed by BaP adsorption due to the increase of surface hydrophobicity. Graphene extracts PS molecules from the layer, and the resultant PS depletion declines with graphene oxidation and BaP adsorption.

Conclusion
GFMs showed high adsorption capacity towards BaPs to form nanocomposites. Upon deposition of GFMs carrying BaPs at the alveolar air–water interface covered by a thin PS layer, the interactions of GFM-PS, GFM-BaP and BaP-PS determined the interfacial processes of BaP solubilization, GFM translocation and PS perturbation.
Social determinants of diabetes‐related foot disease among older adults in New South Wales, Australia: evidence from a population‐based study
Authors: Ahmed Moin Uddin , Tannous Wadad Kathy , Agho Kingsley Emwinyore , Henshaw Frances , Turner Deborah , Simmons David 
Published: December 2021

AbstractBackgroundDiabetes‐related foot is the largest burden to the health sector compared to other diabetes‐related complications in Australia, including New South Wales (NSW). Understanding of social determinants of diabetes‐related foot disease has not been definitive in Australian studies. This study aimed to investigate the social determinants of diabetes‐related foot disease in NSW.MethodologyThe first wave of the 45 and Up Study survey data was linked with NSW Admitted Patient Data Collection, Emergency Department Data Collection, and Pharmaceutical Benefits Scheme data resulting in 28,210 individuals with diabetes aged 45 years and older in NSW, Australia. Three outcome variables were used: diabetes‐related foot disease (DFD), diabetic foot ulcer (DFU), and diabetic foot infection (DFI). They were classified as binary, and survey logistic regression was used to determine the association between each outcome measure and associated factors after adjusting for sampling weights.ResultsThe prevalence of DFD, DFU and DFI were 10.8%, 5.4% and 5.2%, respectively, among people with diabetes. Multivariate analyses revealed that the common factors associated with DFD, DFU and DFI were older age (75 years or more), male, single status, background in English speaking countries, and coming from lower‐income households (less than AUD 20,000 per year). Furthermore, common lifestyle and health factors associated with DFD, DFU, and DFI were low physical activity (< 150 min of moderate‐to‐vigorous physical activity per week), history of diabetes for over 15 years, and having cardiovascular disease.ConclusionOur study showed that about 1 in 10 adults with diabetes aged 45 years and older in NSW reported DFD. Interventions, including the provision of related health services aimed at reducing all forms of DFD in NSW, are recommended to target older individuals with a long history of diabetes, and coming from lower‐income households.
A tailored Internet-delivered modular intervention based on cognitive behavioral therapy for depressed older adults: a study protocol for a randomized controlled trial
Authors: Eimontas Jonas , Pakalniškienė Vilmantė , Biliunaite Ieva , Andersson Gerhard 
Published: December 2021

Abstract
Background
Depression is most common among the elderly and is associated with major impairment. With limited accessible treatments available, remotely provided interventions are needed. Internet-based interventions have been proven effective for a number of mental and somatic health problems. However, the elderly population has received relatively limited attention in previous studies. This study aims to address this gap by investigating the effectiveness of a tailored Internet-delivered modular intervention based on cognitive behavioral therapy (CBT).

Methods
A minimum of 60 participants will be recruited and randomly assigned to groups in a two-armed parallel controlled trial with a waiting list. The intervention group will have access to an 8-week therapist-supported modular intervention. The waiting list group will be instructed to wait for 8 weeks and then granted access to the intervention for 8 weeks. Pre, post, and 3-, 12-, and 24-month follow-up assessments are planned for measuring changes in depression symptoms, anxiety symptoms, and psychological well-being using PHQ-9, GDS, GAD-7, and WHO-5. Primary outcomes of all the participants will be analyzed using the intention-to-treat principle, and within- and between-group effect sizes will be calculated.

Discussion
Internet-based interventions could help address the existing treatment gap for depressed older adults. However, to date, the effectiveness of Internet-based CBT (ICBT) for depressed older adults has only been tested in a few studies. This trial will demonstrate if Internet-based CBT is effective for this population when compared to a waiting list control. Further analysis of secondary outcomes and participant behavior in the intervention will potentially reveal effectiveness moderating factors.

Trial registration
ClinicalTrials.gov NCT04728204. Registered on 15 January 2021. https://www.clinicaltrials.gov/ct2/show/NCT04728204?term=NCT04728204&draw=2&rank=1
Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
Authors: Eun Yeonghee , Kim In-Young , Han Kyungdo , Lee Kyu Na , Lee Dong-Yun , Shin Dong Wook , Kang Seonyoung , Lee Seulkee , Cha Hoon-Suk , Koh Eun-Mi , Lee Jaejoon , Kim Hyungjin 
Published: December 2021

Abstract
Background
Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted an analysis of a large nationwide population-based cohort of postmenopausal women to determine whether there is an association between reproductive factors and the incidence of gout.

Methods
A total of 1,076,378 postmenopausal women aged 40–69 years who participated in national health screenings in 2009 were included in the study. The outcome was the occurrence of incident gout, which was defined using the ICD-10 code of gout (M10) in the claim database. Cox proportional hazard models were used for the analyses and stratified analyses according to body mass index (BMI) and the presence/absence of chronic kidney disease (CKD) were performed.

Results
The mean follow-up duration was 8.1 years, and incident cases of gout were 64,052 (incidence rate 7.31 per 1000 person-years). Later menarche, earlier menopause, and a shorter reproductive span were associated with a high risk of gout. No association between parity and gout incidence was observed. Use of oral contraceptives (OC) and hormone replacement therapy (HRT) were associated with an increased risk of gout. The association between reproductive factors and gout was not statistical significant in the high BMI group. The effects of OC and HRT usage on gout were not significant in the CKD group.

Conclusion
Shorter exposure to endogenous estrogen was associated with a high risk of gout. Conversely, exposure to exogenous estrogen such as OC and HRT was associated with an increased risk of gout.
Gamma-hydroxybutyric acid-induced organic delirium complicated by polydrug use successfully treated with electroconvulsive therapy: a case report
Authors: Kjærgaard Mads F. , Videbech Poul , Nørbæk Jens J. , Ebdrup Bjørn H. 
Published: December 2021

Abstract
Background
Patients with gamma-hydroxybutyric acid withdrawal symptoms are at high risk of developing organic delirium, which can be fatal. The recommended first-line treatment is benzodiazepines, but treatment-resistant cases are frequent. Here we describe a case of successful bilateral electroconvulsive therapy in a patient with severe and highly agitated acute organic delirium induced by gamma-hydroxybutyric acid withdrawal and complicated by polydrug use resistant to first-line treatment. To our knowledge, this is the first report on the effect of electroconvulsive therapy on treatment-resistant delirium caused by gamma-hydroxybutyric acid withdrawal.

Case presentation
A 21-year-old Danish man diagnosed with untreated attention deficit hyperactivity disorder developed severely agitated acute organic delirium caused by gamma-hydroxybutyric acid withdrawal in a Danish psychiatric ward. The patient was subjected to physical restraints and transferred to the intensive care unit for treatment. During the next 10 days, the patient showed no clinical improvement despite first-line, high-dose benzodiazepines along with intense supportive treatment with propofol, phenobarbital, and antipsychotics. On day 11, bilateral frontotemporal electroconvulsive therapy treatment was initiated and full clinical recovery was obtained after four sessions.

Discussion
The full clinical remission after four electroconvulsive therapy sessions, strongly supports that electroconvulsive therapy may be an effective treatment when severe delirium induced by gamma-hydroxybutyric acid withdrawal is resistant to conventional first-line treatment with benzodiazepines. Moreover, this case illustrates that clinically effective seizures were achieved despite intensive concurrent exposure to anticonvulsive drugs. Therefore, this case report encourages consideration of electroconvulsive therapy in patients with gamma-hydroxybutyric acid delirium who are resistant to psychopharmacological treatment.
Spatial prediction of soil acidity and nutrients for site-specific soil management in Bedele district, Southwestern Ethiopia
Authors: Sori Gedefa , Iticha Birhanu , Takele Chalsissa 
Published: December 2021

AbstractBackgroundUnderstanding the spatial variability of soil properties is useful to tailor site-specific agricultural inputs to enhance crop production on a sustainable basis. This study was aimed to assess and map the spatial patterns of soil acidity and nutrients using geostatistical methods and support site-specific lime and fertilizer recommendations in Bedele district, Southwestern Ethiopia.MethodsSoil samples were collected from agricultural land at a depth of 20 cm using grid sampling technique. The semivariogram analysis was performed for accurate spatial prediction and the kriging technique was used for interpolation of soil parameters.ResultsSoil pH varied between 4.5 and 6.8. Soil organic carbon (OC) content ranged from 0.3 to 5.6% and the mean soil OC density was 0.81 kg m−2. Available phosphorus (AvP) ranged from 0.8 to 38.6 mg kg−1and nearly 80.23% of the soils exhibited very low to low AvP that could be due to fixation by strong acidity. Soils of the study area exhibited very high exchangeable potassium (K), but very low exchangeable calcium (Ca) and magnesium (Mg). The potassium to magnesium ratio (K:Mg) ranged from 0.2:1 to 10.9:1, while the values of calcium to magnesium ratio (Ca:Mg) varied between 0.3 and 3.4. Among the soil parameters, exchangeable Ca (CV = 54%) and K:Mg ratio (CV = 57.62%) were more variable than other soil parameters. Spatial variability was lowest for soil pH (CV = 10%).ConclusionsMajor portions of the study site were affected by strong acidity (pH ≤ 5.5). Accordingly, about 89% of the soils require lime that varied between 0.09 and 3.6 tons ha−1. In addition to soil acidity, deficiency of available P, Ca, and Mg were the major liming factors affecting crop production in the study area. Digital soil mapping was used to show the spatial variability of soil acidity and nutrients across agricultural land and applied for efficient lime and nutrients advisory works.
Green chitosan: thiourea dioxide cleaning gel for manganese stains on granite and glass substrates
Authors: Campos Bruno , Marco Alexandra , Cadeco Guilhermina , Freire-Lista David M. , Silvestre-Albero Joaquin , Algarra Manuel , Vieira Eduarda , Pintado Manuela , Moreira Patrícia 
Published: December 2021

Abstract
The cleaning or removal of manganese stains on Cultural Heritage has not been much tested or successful so far. The aim of this article was to assess a new green cleaning gel for Mn-rich black-blue stains on different substrates. The black-blue stains were characterized at optical and chemical level through colour-related data, optical microscope, FTIR, XRF and XPS. Mn-stained granite found on historical churches at Vila Real (North of Portugal) and glass jars of Leclanché cells, belonging to the ISEP’s Museum (Portugal) collection, were the ideal case studies to test the efficiency of chitosan: thiourea dioxide (TD) cleaning gel. TD proved to be the best candidate to reduce insoluble manganese oxides, over Hydroxylamine Hydrochloride and Hydroxymethanesulfinic Acid. Cleaning assays performed on stained granite samples collected at a historical quarry and in situ application on stained granite churches allowed removal of the stains to a satisfactory level. Similar results were obtained on stained glass jars.
Simulation study on parametric dependence of whistler-mode hiss generation in the plasmasphere
Authors: Liu Yin , Omura Yoshiharu , Hikishima Mitsuru 
Published: December 2021

AbstractWe conduct electromagnetic particle simulations to examine the applicability of nonlinear wave growth theory to the generation process of plasmaspheric hiss. We firstly vary the gradient of the background magnetic field from a realistic model to a rather steep gradient model. Under such variation, the threshold amplitude in the nonlinear theory increases quickly and the overlap between threshold and optimum amplitude disappears correspondingly, the nonlinear process is suppressed. In the simulations, as we enlarge the gradient coefficient of the background magnetic field, waves generated near the equator do not grow through propagation. By examining the range of suitable values of inhomogeneity factorS(i.e.,$$|S|<2$$|S|<2), we find the generation of wave packets is limited to the equatorial region when the background field is steep, showing a good agreement with what is indicated by critical distance in the theory. We then check the dependence of generation of hiss emissions on different hot electron densities. Since the overlap between threshold and optimum amplitude vanishes, the nonlinear process is weakened when hot electron density becomes smaller. In the simulation results, we find similar wave structures in all density cases, yet with different magnitudes. The existence of suitableSvalues implies that the nonlinear process occurs even at a low level of hot electron density. However, by examining$$J_E$$JEthat closely relates to the wave growth, we find energy conveyed from particles to waves is much limited in small density cases. Therefore, the nonlinear process is suppressed when hot electron density is small, which agrees with the theoretical analysis.Graphical Abstract
Early transcriptomic response of the mycoparasite Sphaerodes mycoparasitica to the mycotoxigenic Fusarium graminearum 3-ADON, the cause of Fusarium head blight
Authors: Kim Seon Hwa , Vujanovic Vladimir 
Published: December 2021

AbstractMycoparasites are an assemblage of biotrophic and necrotrophic fungi that occur on plant pathogenic fungal hosts. Biotrophic mycoparasites are often overlooked in transcriptomic-based biocontrol studies. Sphaerodes mycoparasitica (S.m.) is a specific biotrophic mycoparasite of plant pathogenic Fusarium graminearum (F.g.), a devastating Fusarium head blight (FHB) disease in small-grain cereals. To understand the biotrophic mycoparasitism comprehensively, we performed Illumina RNA-Seq transcriptomic study on the fungus–fungus interaction in vitro. The aim is to identify the transcript-level mechanism related to the biotrophic S.m. mycoparasitism, particularly its ability to effectively control the F.g. 3-ADON chemotype. A shift in the transcriptomic profile of the mycoparasite was triggered in response to its interaction with F.g. during recognition (1.5 days) and colonization (3.5 days) steps. RNA-Seq analysis revealed ~ 30% of annotated transcripts with "function unknown". Further, 14 differentially expressed genes functionally linked to the biotrophic mycoparasitism were validated by quantitative real-time PCR (qPCR). The gene expression patterns of the filamentous haemagglutinin/adhesin/attachment factor as well as cell wall-degrading glucanases and chitinases were upregulated by host interaction. Besides, mycoparasitism-associated antioxidant resistance genes encoding ATP-binding cassette (ABC) transporter(s) and glutathione synthetase(s) were upregulated. However, the thioredoxin reductase was downregulated which infers that this antioxidant gene can be used as a resistance marker to assess S.m. antifungal and antimycotoxigenic activities. The interactive transcriptome of S. mycoparasitica provides new insights into specific mycoparasitism and will contribute to future research in controlling FHB.
Graphic Abstract
Advances in the design and development of SARS-CoV-2 vaccines
Authors: Peng Xue-Liang , Cheng Ji-Si-Yu , Gong Hai-Lun , Yuan Meng-Di , Zhao Xiao-Hong , Li Zibiao , Wei Dai-Xu 
Published: December 2021

AbstractSince the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious and prone to rapid mutation, encodes both structural and nonstructural proteins. Vaccination is currently the only effective method to prevent COVID-19, and structural proteins are critical targets for vaccine development. Currently, many vaccines are in clinical trials or are already on the market. This review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19, including viral vector vaccines, DNA vaccines, RNA vaccines, live-attenuated vaccines, inactivated virus vaccines, recombinant protein vaccines and bionic nanoparticle vaccines. In addition to traditional inactivated virus vaccines, some novel vaccines based on viral vectors, nanoscience and synthetic biology also play important roles in combating COVID-19. However, many challenges persist in ongoing clinical trials.
Post-traumatic rectourethral fistula in an adolescent managed via a transperineal approach using a local gluteal tissue interposition flap: a case report
Authors: Hirano Toshinori , Ohge Hiroki , Watadani Yusuke , Uegami Shinnosuke , Shimada Norimitsu , Nakashima Ikki , Yoshimura Kosuke , Takahashi Shinya 
Published: December 2021

Abstract
Background
Rectourethral fistula is a rare disease with a wide variety of etiologies and clinical presentations. A definitive surgical procedure for rectourethral fistula repair has not been established.

Case presentation
A 13-year-old boy sustained a penetrating injury to the perineum, and developed a symptomatic rectourethral fistula thereafter. Conservative management through urinary diversion and transanal repair was unsuccessful. Fecal diversion with loop colostomy was performed, and three months later, a fistula repair was performed via a transperineal approach with interposition of a local gluteal tissue flap. There were no postoperative complications, and magnetic resonance imaging studies confirmed the successful closure of the fistula. The urinary and fecal diversions were reverted 1 and 6 months after the fistula repair, respectively, and postoperative excretory system complications did not occur.

Conclusions
The transperineal approach with interposition of a local gluteal tissue flap provides a viable surgical option for adolescent patients with rectourethral fistulas who are unresponsive to conservative management.