bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between sleep duration and frailty: findings from the China Health and Retirement Longitudinal Study
Authors: Huang Liyan , He Xiaofang , Zuo Yao , Yang Hui , Zhang Lin 
Published: December 2024

BackgroundResearch investigating the association between sleep duration and the risk of frailty has yielded conflicting results. This study used data from the China Health and Retirement Longitudinal Study (CHARLS) to investigate the association between sleep duration and frailty.MethodsParticipants aged 45 and above at baseline were included in this study. Night or total sleep was categorized into three groups: short (&lt;6 h), normal (6–9 h), and long sleep duration (≥9 h). Frailty was measured by a 31-item frailty index (FI). Non-frail participants at baseline were followed up after a 7-year period. The association between sleep duration and FI was examined by linear regression and restricted cubic spline (RCS) analysis. The relationship between sleep duration and the risk of frailty was evaluated using multinomial logistic regression analysis.ResultsA total of 10,258/10,250 (night/total sleep duration) participants were included in the cross-sectional study and 4,770/4,768 in the longitudinal study. A negative correlation was identified between the both night and total sleep duration and FI (night: β = −0.83, p &lt; 0.001; total: β = −0.66, p &lt; 0.001) after adjusting for age, sex, education level, marital status, residence, yearly expenditure, BMI, waist circumference, smoking status, and drinking status in the cross-sectional study. In the longitudinal study, the relationship remained. Short sleep duration increased FI (night: β = 3.59, p &lt; 0.001; total: β = 3.74, p &lt; 0.001) and the risk of frailty (night: OR [95% confidence interval (CI)], 1.06 [1.05, 1.08], p &lt; 0.001; total: 1.07 [1.06, 1.08], p &lt; 0.001) compared to normal sleep duration in the fully adjusted model of the cross-sectional study. The result remains consistent in the longitudinal analysis.ConclusionShort sleep duration increases the risk of frailty in Chinese individuals aged 45 and above. Extending sleep duration in this population may help prevent or alleviate frailty among middle-aged and older adult individuals.
Stop to smell the virtual roses: a mixed-methods pilot study on the impact of multisensory virtual reality nature experiences on feelings of relaxation
Authors: Lopes Marilia Karla Soares , De Jesus Belmir Jose , Rosanne Olivier Manuel , Pardini Susanna , Appel Lora , Smith Christopher , Falk Tiago Henrique 
Published: December 2024

IntroductionThis study aimed to investigate the psychological and physiological impacts of audio-visual (AV) and audio-visual-olfactory (AVO) stimuli within an immersive virtual nature environment.MethodsTwenty-two nurses from the mental health in-patient ward of a Canadian hospital participated in the study. Each participant chose one of the three available immersive scenarios (beach, lake, waterfall) to experiment with under the AV and AVO conditions. Psychological assessments were conducted via questionnaires to investigate relaxation levels and other measures of user experience. Although the AVO condition demonstrated the greatest improvement in relaxation relative to baseline, no significant differences were observed either between the conditions or across the scenarios. Physiological metrics were collected using an in-house instrumented Oculus Quest 2 virtual reality (VR) headset that allowed us to investigate brain activity via electroencephalography (EEG).ResultsResults show a significant difference between the two conditions in certain brain regions. Significant differences in neural patterns were also seen for the participants who reported improvements in relaxation, relative to those who did not report any improvements. For these latter-referenced participants, decreased relaxation resulted from the non-congruence of the presented smells with participant expectations. Furthermore, neuromarkers measured from the EEG, such as frontal alpha asymmetry (a measure of approach/withdrawal), engagement score, as well as valence and arousal indices suggested increased relaxation levels in the AVO condition.ConclusionOur results suggest that multisensory immersive experiences can impact both physiological and psychological outcomes, resulting in increased relaxation levels and enhanced sense engagement for certain scenes. The instrumented VR headset enabled the monitoring of user neural and behavioural patterns, thus allowing for new insights to be gained beyond those achievable with only questionnaires.
Wheat productivity and nitrogen use efficiency in no-till systems: a comparative analysis of crop-pasture and continuous cropping rotations in Uruguay
Authors: Mori Alvez Cristina , Ernst Benech Oswaldo , González Barrios Pablo , Perdomo Varela Carlos 
Published: December 2024

IntroductionUruguayan agriculture’s transition to no-till farming and intensified practices, replacing crop-pasture (CP) systems with continuous cropping (CC) rotations, has disrupted biological nitrogen fixation (BNF). Despite this, diversified cropping sequences, including C4 species, have maintained the soil organic carbon (SOC) balance under no-till management, with limited overall impacts on productivity and sustainability. The effects of these changes on wheat productivity and nitrogen use efficiency (NUE) need to be further investigated.MethodsThis study, conducted within a long-term experiment (LTE) under rainfed conditions, compared wheat productivity in CP and CC rotations. Wheat following CP and CC were analyzed over three seasons. Variables measured included soil nitrogen (N) concentration, wheat grain yield (WGY), grain protein concentration (GPC), and NUE. Four N fertilizer levels were applied to each rotation system to assess their impact.ResultsCC rotation consistently outperformed CP in WGY, with 2425 and 1668 kg ha−1 averages, respectively. CP showed slightly higher GPC (10.92%) than CC (10.48%). Nitrate-N levels at tillering positively correlated with WGY and negatively with GPC, but the relationship differed by rotation. Soil NUE indices were higher in CC rotations.DiscussionThe study’s findings highlighted the potential of CC rotation, especially when including C4 species in the crop sequence, to achieve higher wheat productivity in the short term due to healthier soil conditions compared to wheat seeded after post-pasture in CP. Additionally, our study highlights that the effect of the previous crop on yield and NUE in wheat was more relevant than the expected residual effect of the pasture phase in CP, primarily due to the quality of residues and the temporary adverse effects of soil compaction caused by livestock trampling.
Comparative analysis of PFASs concentrations in fur, muscle, and liver of wild roe deer as biomonitoring matrices
Authors: Draghi Susanna , Curone Giulio , Risoluti Roberta , Materazzi Stefano , Gullifa Giuseppina , Amoresano Angela , Spinelli Michele , Fontanarosa Carolina , Pavlovic Radmila , Pellegrini Alberto , Fidani Marco , Cagnardi Petra , Di Cesare Federica , Arioli Francesco 
Published: December 2024

BackgroundRecently, environmental pollution has become a significant concern for human, animal, and environmental health, fitting within the “One Health” framework. Among the various environmental contaminants, per- and polyfluoroalkyl substances (PFASs) have gathered substantial attention due to their persistence, bioaccumulation, and adverse health effects. This study aimed to compare the levels of 12 PFASs in the fur, liver, and muscle of wild roe deer to evaluate the feasibility of using fur as a non-invasive biomonitoring matrix.MethodsA total of 20 male and 20 female roe deer aged between 12 and 24 months were randomly sampled from a hunting area in Northern Italy. Samples of fur, muscle, and liver were collected post-mortem, and PFAS concentrations were measured using a validated UHPLC-HRMS method.Results and discussionThe results indicated significant differences in PFAS concentrations among the three matrices. Fur, although easier to sample and store, showed highly variable PFAS levels, with different detection frequencies compared to the muscle and liver. PFASs such as PFHxA were more frequently detected in fur than in the liver and muscle, while compounds such as PFBA, PFPeA, PFHpA, PFDA, PFHxS, 6-2 FTS, and 8-2 FTS were less frequently detected in fur. In conclusion, while fur presents many practical advantages for biomonitoring, such as non-invasive sampling and stability, its use is complicated by varying detection frequencies and concentration levels. These aspects, together with the use of a single sampling technique, can be considered a limitation of the study. Notably, compounds such as PFOA, PFNA, and PFOS showed partially similar detection frequencies across the matrices, suggesting potential interest for further research. This study offers new perspectives on the use of fur for environmental monitoring, highlighting the need for more extensive research to understand the relationship between PFAS concentrations in fur and other biological matrices. Future studies should focus on methodological improvements in extraction and quantification techniques for PFASs in fur to enhance their reliability as a biomonitoring tool.
Comparison of average daily gain, apparent digestibility, rumen fermentation parameters and bacterial communities, and serum antioxidant indices in Leizhou goats fed with or without rumen-protected fat
Authors: Liu Hu , Mao Hongxiang , Wang Wenji , Peng Weishi , Mao Kaiyu , Sun Wei , Yang Yuanting , Wu Qun , Wang Ke , Zeng Meng , Han Jiancheng , Zhou Hanlin 
Published: December 2024

IntroductionRumen-protected fat (RPF) is a vital dietary energy source for dairy cows. However, the influences of RPF on rumen volatile fatty acid (VFA) content and bacterial communities in goats are poorly documented.MethodsIn this study, 12 castrated male goats (body weight [BW]: 13.3 ± 0.02 kg; 6 months of age) were used as the experimental animal and then allocated into two groups (n = 6): a control group, fed a basal diet without RPF supplementation, and the RPF supplementation group, fed a basal diet with 2.4% RPF supplementation.ResultsThe final BW and ADG were higher (p &lt; 0.05) and the ratio of dry matter (DM) intake to ADG was lower (p &lt; 0.05) in the 2.4% RPF supplementation group compared with those in the control group. The 2.4% RPF supplementation group showed a higher total tract digestibility of DM, CP, OM, neutral and acid detergent fiber compared with that of the control group (p &lt; 0.05). The proportion of acetate was higher (p &lt; 0.05) and that of propionate was lower (p &lt; 0.05) in the 2.4% RPF supplementation group compared with those in the control group. The relative abundances of Christensenellaceae_R-7_group, unclassified_f__Selenomonadaceae, norank_f__Selenomonadaceae, Quinella, norank_f__Bacteroidales_RF16_group, and unclassified_o__Bacteroidales were higher (p &lt; 0.05) and those of Lachnospiraceae_NK3A20_group, norank_f__F082, Olsenella, Erysipelatoclostridiaceae_UCG-004, and Syntrophococcus were lower (p &lt; 0.05) in the 2.4% RPF supplementation group compared with those in the control group.DiscussionIn conclusion, 2.4% RPF supplementation can improve the ADG and antioxidant capacity by regulating the rumen bacterial communities and enhancing the apparent total tract digestibility in growing Leizhou goats.
Can we predict hypoadrenocorticism in dogs with resting hypocortisolemia? A predictive model based on clinical, haematological, and biochemical variables
Authors: Santos Nuno Sousa , Domingues Tiago Dias , Tardo Antonio Maria , Dinis Marta , Mateus Luísa , Fracassi Federico , Leal Rodolfo Oliveira 
Published: December 2024

BackgroundA resting cortisol concentration (RC) higher than 2.0 μg/dL (55 nmol/L) is commonly used to rule out hypoadrenocorticism (HA). However, there is a significant overlap of RC between dogs with HA and those with other diseases. There is a need for data to help increase the suspicion of HA.Hypothesis/objectivesTo create a predictive model based on clinical, haematological and biochemical variables to increase the likelihood of diagnosis of hypoadrenocorticism.AnimalsNinety-two dogs with RC &lt;2.0 μg/dL, and an adrenocorticotropic hormone stimulation test (ACTHst) performed.MethodsMulticentric retrospective cohort study with review of medical records of client-owned dogs presented to two referral centres, between January 2018 and March 2022. Dogs were divided into two groups (HA and not HA), based on ACTHst results. Descriptive analysis was performed along with a predictive model, using univariable and multivariable logistic regression analysis.ResultsOf the 92 included dogs, hypoadrenocorticism was diagnosed in 29 patients (32.2%) based on ACTHst results (HA group). Acute gastrointestinal signs, anorexia and lethargy were more prevalent in the HA group. Creatinine, BUN, ALT, and potassium were higher, and albumin, sodium and Na/K ratio were lower in the HA group. Multivariate analysis developed a robust model in which lethargy (OR 5.25), anorexia (OR 3.69), albumin (OR 0.32), and sodium (OR 0.84) concentrations allowed the prediction of HA.Conclusions and clinical importanceIn dogs with resting hypocortisolemia, the combination of anorexia and lethargy, along with low sodium and albumin concentrations, should raise the suspicion of hypoadrenocorticism. The variables identified in this study may help clinicians to identify dogs with hypoadrenocorticism in daily clinical practice.
Drought Stress Inhibits the Accumulation of Rotenoids and the Biosynthesis of Drought-Responsive Phytohormones in Mirabilis himalaica (Edgew.) Heim Calli
Authors: Zhang Shiyi , Gao Jiaqi , Lan Xiaozhong , Zhang Linfan , Lian Weipeng , Wang Chenglin , Shen Zhanyun , Li Xiang , Liu Juan 
Published: December 2024

Background: Mirabilis himalaica, distributed in the high-altitude, arid, and semi-arid regions of Xizang, exhibits great tolerance to drought, which is rich in rotenoids and other secondary metabolites. It is still unknown, though, how drought stress influences rotenoid synthesis in M. himalaica. Methods: In this study, the calli of M. himalaica were subjected to 5% PEG6000 for 0, 20, and 40 h and divided into control group (CK), mild-drought-treated group (M), and high-drought-treated group (H), respectively. We then analyzed the relative content of three main rotenoids in M. himalaica using high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (HPLC-ESI-MS/MS). Results: Our findings demonstrated that the content of rotenoids was significantly reduced under drought stress. Transcriptome analysis subsequently revealed 14,525 differentially expressed genes (DEGs) between the different treatments. Furthermore, these DEGs exhibited enrichment in pathways associated with isoflavone biosynthesis and hormone signaling pathways. Key genes with decreased expression patterns during drought stress were also found to be involved in rotenoid accumulation and drought-responsive phytohormone signaling, including abscisic acid (ABA), auxin (IAA), and jasmonic acid (JA). Conclusions: These findings elucidate the molecular processes of drought resistance in M. himalaica and shed light on the relationship between rotenoid production and drought stress in M. himalaica.
نظام ذكي لدعم القرار للتنبؤ بأقصى حمولة كهرباء لدولة الإمارات العربية المتحدة
Authors: بدري مسعود عبدالله 
Published: December 2024

التنبؤ بأقصى حمولة كهربا، يعتبر من الأمور الرئيسية لدى المسؤولين عن عمليات التخطيط والتصريف الأمثل للموارد في شركات الكهرباء، وتشير الأبحاث السابقة أن هناك نماذج تم تطويرها حسب المتغيرات (العوامل) الخاصة بكل بيئة كما أظهرت هذه الأبحاث نتائج متباينة في ظل البيانات المختلفة.
تهدف هذه الدراسة إلى تصميم وإختبار النماذج المختلفة للسلاسل الزمنية، مثل نماذج بوكس جنكيز والتمهيد الطردي والإنحدار الديناميكي، بغية إختيار الأنسب منها لكل إمارة في دولة الإمارات العربية المتحدة. ولقد تم تصميم نظام ذكي لدعم القرار تلقائيا وبشكل أتوماتيكي بتحليل وإختبار النماذج المختلفة واختيار الأمثل منها دون قيام مستخدم النظام بأي تدخل مباشر، وتشير نتائج الدراسة إلى أن نماذج بوكس جنكثر ونماذج التمهيد الطردي تعتبر الأمثل لهذه الإمارات.
In the Labyrinths of Phenomenology (of Art): Report from the Debate
Authors: Jemioł Maciej 
Published: December 2024

On March 26th, 2024, an online debate organized by the Institute of Philosophy of Ignatianum University in Cracow took place. The debate was centered around the book "Fenomenologia i jej cień. Zwrot estetyczny w post-fenomenologii francuskiej" ("Phenomenology and its Shadow. The Aesthetic Turn in French Post-Phenomenology"), written by Monika Murawska (Academy of Fine Arts in Warsaw) and published by Wydawnictwo Instytutu Filozofii i Socjologii Polskiej Akademii Nauk in 2023.
Besides the author of the book, the following guests were also in attendance: Anna Alichniewicz (Medical University of Łódź), Mateusz Bednarkiewicz (Aleksander Zelwerowicz National Academy of Dramatic Art in Warsaw), Iwona Lorenc (University of Warsaw) and Piotr Schollenberger (University of Warsaw). The debate was led by Magdalena Kozak (Ignatianum University in Cracow).
Can Personalism be First Philosophy? Review of Juan Manuel Burgos’s Book “Personalism and Metaphysics”
Authors: Mietelski Tymoteusz 
Published: December 2024

In this publication, readers with only a somewhat limited philosophical background will encounter a wonderful and clear introduction to the metaphysics of Aristotle and St. Thomas, while supporters of personalism will become familiar with Burgos’s interesting and original proposal (which is nevertheless deeply rooted in the tradition associated with this current of thought). At the same time, critically minded readers will be able to familiarize themselves with the author’s lucidly presented arguments and reflect on their strength and plausibility. To sum up, it can be said that this is a book worth recommending to a wide audience.
Cost-Utility Analysis of Add-on Cannabidiol vs Usual Care Alone for the Treatment of Seizures in Patients With Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the Netherlands
Authors: Siddiqui Jamshaed , Bowditch Sally 
Published: December 2024

Background: Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) are severe, treatment-refractory, epileptic encephalopathies that often develop in infancy or early childhood. Since December 1, 2022, plant-derived highly purified cannabidiol (CBD) medicine (Epidyolex®; 100 mg/mL oral solution) has been reimbursed in the Netherlands for the adjunctive treatment of seizures associated with LGS or DS. Objective: To estimate the cost-effectiveness of CBD plus usual care vs usual care alone in patients with LGS or DS in the Netherlands. Methods: A cohort-based Markov model from a Dutch societal perspective, based on seizure frequency and seizure-free days, was developed for patients receiving CBD plus usual care (antiseizure medications, including clobazam) or usual care alone. Population characteristics, clinical inputs, and utility values were sourced from CBD clinical trials and quality-of-life studies. Drug acquisition, disease management, adverse events, and societal costs from published literature were included. A 2019/2020 price year in euros was used. The model used a mean dosage of 12 mg/kg/day, a lifetime (90-year) horizon, and a 3-month cycle length. Discount rates of 4.0% and 1.5% per annum were applied to costs and outcomes, respectively. Uncertainty was explored through deterministic and probabilistic sensitivity analyses. Results: In patients with LGS, CBD plus usual care led to additional costs of €28 338 and increased quality-adjusted life-years (QALYs) of 1.318 compared with usual care alone. The incremental cost-effectiveness ratio of €21 493/QALY in LGS is below the willingness-to-pay threshold of €80 000/QALY in the Netherlands. In patients with DS, CBD plus usual care dominated usual care alone, with cost savings of €23 642 and increased QALYs of 0.868. The probability that CBD plus usual care is cost-effective in the Netherlands compared with usual care alone is 96% and 99% in patients with LGS and DS, respectively. Discussion: Elicitation methods were used to address data gaps in model inputs (eg, healthcare resource utilization and utilities); Dutch clinical experts, sensitivity, and scenario analyses validated this approach. Conclusions: Based on a willingness-to-pay threshold of €80 000, the base case cost-utility analysis demonstrated the cost-effectiveness of CBD plus usual care in patients with treatment-refractory LGS or DS aged 2 years or older in the Netherlands.
KOMODIFIKASI ADZAN MAGRIB RAMADAN KARTUN UPIN-IPIN DI MNC TV
Authors: Wibowo Ganjar , Saefuddin Bunnaya 
Published: December 2024

<p><em>Through the media political economy approach, this study reveals how the commodification performed on impressions insertion Adzan Maghrib animation Upin Ipin in the month of Ramadan</em><em> </em><em>which took place in Station Media Nusantara Citra Televisi (MNCTV) Jakarta. The results showed that the commodification shows inset Adzan Maghrib Ramadan took place behind the ideology of the political economy of the media. Commodification of the Adzan Maghrib Ramadan Upin-Ipin animation study of content, workers and audiences. Outside Ramadan Adzan Maghrib a regular insertion program but during Ramadan maghrib call to prayer was turned into a privileged, by the media workers trafficked profit even doubled. This study uses a critical paradigm with a qualitative approach. In the process of commodification of the Adhan maghrib animation Upin-Ipin Ramadan the practice of trade transactions and multiple profits involving elements, content of workers and the audience.</em></p>
Pengaruh Intensitas penggunaan instagram terhadap eksistensi diri pada siswa siswi SMK
Authors: Fadzilah Ishmah Nur , Bahriyah Euis Nurul , Tambunan Resman M , Faaroek Safiani A 
Published: December 2024

<p>Instagram merupakan media sosial yang banyak diminati para remaja. Hal ini dikarenakan instagram lebih fokus pada foto dan video dibandingkan dengan media sosial lainnya. Hal ini memuncukan eksistensi pada setiap pengguna akun instagram lewat foto dan video yang menarik. Terdapat dalah satu faktor eksistensi diri yaitu angka pada akun instagram pengguna. Oleh karena itu hal ini menjadi latar belakang peneliti untuk meneliti. Pada penelitian ini teori yang digunakan yaitu sirkular teori. Penelitian ini bertujuan untuk mengetahui pengaruh intensitas penggunaan instagram terhadap eksistensi diri pada siswa-siswi SMK Telkom Jakarta. Variabel Independen penelitian ini yaitu intensitas penggunaan instagram, variabel dependen penelitian ini adalah eksistensi diri. Penelitian ini dilakukan pada siswa-siswi di SMK Telkom Jakarta yang aktif menggunakan aplikasi instagram. Sampel yang digunakan sebanyak 90 responden dengan teknik pengambilan sampel yaitu <em>Formula Slovin</em>. Jenis penelitian ini adalah kuantitatif dan metode yang digunakan dalam penelitian ini adalah survei dengan menggunakan teknik Analisis Regresi Linear Sederhana.</p><p align="left"> </p><p>Hasil pada penelitian ini menunjukkan bahwa intensitas penggunaan instagram berpengaruh secara positif dan kurang signifikan terhadap eksistensi diri, hal ini dapat dilihat dari pengolahan data, angka signifikansi menunjukkan sebesar 0,000 yang berarti &lt; 0,05, sehingga dapat disimpulkan bahwa intensitas penggunaan instagram berpengaruh terhadap eksistensi diri. Atau Ha diterima dan Ho ditolak. Untuk nilai koefisien determinasi (RSquare) sebesar 0,253 yang mengandung pengertian bahwa pengaruh Intensitas penggunaan instagram terhadap Eksistensi diri adalah sebesar 25,3%, yang berarti termasuk dalam pengaruh kategori rendah.</p>