bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of State-Level Production Outcomes upon U.S. National Corn and Soybean Production: A Novel Application of Correlated Component Regression
Authors: Bullock David W. 
Published: February 2021

AbstractThe relative importance of key state-level outcomes upon U.S. national corn and soybean production was examined usingcorrelated component regression, a recently developed regression technique for application to multicollinear and sparse data sets. Standardized coefficients were used to rank the states’ relative importance. A Herfindahl-Hirschman Index was used to measure the degree of concentration among the top ranked states. The empirical analysis looked at two time periods: a pre-Genetic Modification (1975–1995) and a post-Genetic Modification (1996–2017) period. The results indicate that U.S. corn production is becoming less geographically concentrated in terms of state-level importance while the opposite holds true for soybean production.
Is It Better to Be Objectively Wrong or Subjectively Right?
Authors: Bloch Lindsay C. , Hosen Jacob D. , Kracht Emily C. , LeFebvre Michelle J. , Lopez Claudette J. , Woodcock Rachel , Keegan William F. 
Published: February 2021

ABSTRACTFor many years, archaeologists have relied on Munsell Soil Color Charts (MSCC) as tools for standardizing the recording of soil and sediment colors in the field and artifacts such as pottery in the lab. Users have identified multiple potential sources of discrepancy in results, such as differences in inter-operator perception, light source, or moisture content of samples. In recent years, researchers have developed inexpensive digital methods for color identification, but these typically cannot be done in real time. Now, a field-ready digital color-matching instrument is marketed to archaeologists as a replacement for MSCC, but the accuracy and overall suitability of this device for archaeological research has not been demonstrated. Through three separate field and laboratory trials, we found systematic mismatches in the results obtained via device, including variable accuracy against standardized MSCC chips, which should represent ideal samples. At the same time, the instrument was consistent in its readings. This leads us to question whether using the “subjective” human eye or the “objective” digital eye is preferable for data recording of color. We discuss how project goals and limitations should be considered when deciding which color-recording method to employ in field and laboratory settings, and we identify optimal procedures.
Hand hygiene and glove use in nursing homes before and after an intervention
Authors: Teesing Gwen R. , Richardus Jan Hendrik , Erasmus Vicki , Petrignani Mariska , Koopmans Marion P. G. , Vos Margreet C. , Schols Jos M.G.A. , Voeten Helene A.C.M. 
Published: February 2021

AbstractWe investigated whether an intervention to improve hand hygiene compliance in nursing homes changed glove use. Hand hygiene compliance increased, but substitution of hand hygiene with gloves did not decrease. We observed a reduction of inappropriately unchanged gloves after exposure to body fluids.Clinical trials identifier: Netherlands Trial Register, trial NL6049 (NTR6188): https://www.trialregister.nl/trial/6049.
Evaluation of an initiative to improve prophylactic antimicrobial prescribing in patients on extracorporeal membrane oxygenation (ECMO) through the application of three antimicrobial-spectrum scores
Authors: Shah Aditya , Stevens Ryan W. , O’Horo John C. , Dierkhising Ross A. , Estes Lynn L. , Berbari Elie F. , Tande Aaron J. 
Published: February 2021

AbstractAntimicrobial spectrum scoring is a method to quantify the spectrum of antimicrobial utilization. Herein, we applied a locally adapted scoring system, with other pre-existing scoring systems, using a data set of prophylactically administered antibiotics following a 2-stage antimicrobial stewardship program (ASP) intervention in a population of patients on extracorporeal membrane oxygenation (ECMO).
Political Socialisation: Out of Purgatory?
Authors: Haegel Florence 
Published: February 2021

AbstractThis paper aims to put contemporary political socialisation research in perspective. It offers a rapid overview of the crisis of the subfield after the 1970s and then shifts attention to post-crisis studies. Beginning with child political socialisation, it raises four issues: the use of theoretical frameworks derived from child psychology; the need to reconnect political socialisation to the sociology of family; the benefits of renewing methods for understanding the world of child politics; and a new account of social inequality in the process of political socialisation. It then explores lifelong political socialisation and how it has developed around four research dynamics: the study of civic and political socialisation of school-age adolescents and young adults; the generational renewal; the socialising effects of political mobilisation; and the processes and agents of the secondary political socialisation of adults. The final section raises the major question of what is political in political socialisation.
Politicizing International Cooperation: The Mass Public, Political Entrepreneurs, and Political Opportunity Structures
Authors: De Vries Catherine E. , Hobolt Sara B. , Walter Stefanie 
Published: February 2021

AbstractInternational institutions are increasingly being challenged by domestic opposition and nationalist political forces. Yet, levels of politicization differ significantly across countries facing the same international authority as well as within countries over time. This raises the question of when and why the mass public poses a challenge to international cooperation. In this article, we develop a theoretical framework for understanding the nature and implications of politicization of international cooperation, outlining three scope conditions: the nature of public contestation, the activities of political entrepreneurs, and the permissiveness of political opportunity structures. By empirically examining these scope conditions, we demonstrate that politicization can have both stabilizing and destabilizing effects on international cooperation. Highlighting the systemic implications of politicization for international cooperation has important implications for international relations scholarship. Although international organizations may face challenges, they also have ways of being remarkably resilient.
Built on Borders: Tensions with the Institution Liberalism (Thought It) Left Behind
Authors: Simmons Beth A. , Goemans Hein E. 
Published: February 2021

AbstractThe Liberal International Order is in crisis. While the symptoms are clear to many, the deep roots of this crisis remain obscured. We propose that the Liberal International Order is in tension with the older Sovereign Territorial Order, which is founded on territoriality and borders to create group identities, the territorial state, and the modern international system. The Liberal International Order, in contrast, privileges universality at the expense of groups and group rights. A recognition of this fundamental tension makes it possible to see that some crises that were thought to be unconnected have a common cause: the neglect of the coordinating power of borders. We sketch out new research agendas to show how this tension manifests itself in a broad range of phenomena of interest.
An institutional ethnographic analysis of public and patient engagement activities at a national health technology assessment agency
Authors: Bidonde Julia , Vanstone Meredith , Schwartz Lisa , Abelson Julia 
Published: February 2021

Abstract

Objective
The practice of public and patient engagement (PPE) in health technology assessment (HTA) has spread worldwide, yet gaps in knowledge remain. We carried out an institutional ethnography of the Canadian Agency for Drugs and Technologies in Health (CADTH) public and patient involvement in HTA.

Methods
The research took place over 15 months and included observational work in the institutional settings, text review, and interviews with individuals working for or involved with the agency.

Results
We found that despite demonstrated commitment to PPE, organizational history, governance structure, and practices were impediments to a unified approach to PPE. Unclear role descriptions for committee members and differences in philosophy and priority given to PPE across the organization presented challenges to effective participation. The high degree of value given to evidence-based principles at times conflicted with meaningful integration of patient input. A lack of clear goals and processes, roles, and differential treatment of evidence in PPE served to minimize the importance of patient experiences and to displace their validity. An acknowledgment of conflicts between multiple epistemic traditions at work within HTA activities may strengthen organizational approaches to PPE.

Conclusion
HTA organizations can learn from this study by reflecting on the challenges described and the recommendations offered to address them. We suggest solidifying CADTH's commitment to PPE with clear agency-wide roles and direction, values, and outcomes, a comprehensive framework, and policy and procedures. An acknowledgment of diverse epistemic traditions, as well as leadership and expertise in PPE, will strengthen CADTH's PPE activities and sustain its leadership position in the HTA field.
Analysis of impact of group delay on slope distortion of S-curve in delay locked loop
Authors: Liu Yuqi , Ran Yihang , Yang Yi , Chen Lin , Xiong Tuling , Pan Hongchen 
Published: February 2021

AbstractAs essential specifications of correlation domain for signal quality evaluation, distortions of the S-curve, including bias and slope distortions of the zero-crossing point, are usually selected as indicators of optimisation in the process of designing the channels of receivers or navigation satellites. Focusing on this issue, we present a detailed analysis of slope distortion in the presence of group delay and amplitude distortions. After validating the theoretical results, we present further discussions about the impacts of different group delay terms on slope distortions. The results indicate that both the odd-order and the even-order terms have impacts on the slope distortion, and higher odd-order terms have less slope distortion compared with the lower odd-order terms. These results are useful for evaluating the slope distortion from the group delay and guiding improvement in design of the channel.
Radiation dermatitis: the evaluation of a new topical therapy for the treatment and prevention of radiation-induced skin damage and moist desquamation: a multicentre UK case cohort study
Authors: Johnson K. , Fenton G. , White R. J. 
Published: February 2021

AbstractIntroduction:Radiotherapy is a mainstay of cancer therapy for a wide variety of anatomical areas. An unfortunate side effect of treatment can be radiation damage to the skin which can be a painful and debilitating problem. Previous experience from the experimental use of Flamigel® in two large-scale clinical studies on affected skin has proven sufficiently positive for the addition of a new product in the Flamigel® family (now commercially available in the UK as Flamigel RT®, Flen Health UK). The aim of this investigation is to evaluate the use of this new product to study how effective it is in the prevention and/or treatment of radiation-induced skin damage.Materials and methods:A survey was conducted among radiotherapy specialist teams in dedicated UK radiotherapy centres between 1 January 2017 and 31 October 2017. This report is of a preliminary evaluation conducted by UK-based specialists on 108 patients undergoing radiotherapy. The scoring system for skin reactions of the ‘Radiation Therapy Oncology Group’ was used.Results:Results show that the use of Flamigel® has the potential to soothe (p = 0·0001), reduce pain (p = 0·0001) and reduce pruritus (p = 0·004). The product met the expectations of the clinicians involved (p < 0·0001) of whom most were happy to continue use or to recommend its use to colleagues (p < 0·0001).Conclusions:Flamigel® is an effective treatment in the management of radiation-induced skin reactions. Erythema was unchanged through the study period (p = 0·42). No adverse reactions were reported after the use of Flamigel from twice to six times a day.
Delivery of Metals and Dissolved Black Carbon to the Southern California Coastal Ocean via Aerosols and Floodwaters Following the 2017 Thomas Fire
Authors: Kelly Rachel L. , Bian Xiaopeng , Feakins Sarah J. , Fornace Kyrstin L. , Gunderson Troy , Hawco Nicholas J. , Liang Hengdi , Niggemann Jutta , Paulson Suzanne E. , Pinedo‐Gonzalez Paulina , West A. Joshua , Yang Shun‐Chung , John Seth G. 
Published: February 2021

AbstractThe Thomas Fire began on December 4, 2017 and burned 281,893 acres over a 40‐day period in Ventura and Santa Barbara Counties, making it one of California's most destructive wildfires to date. A major rainstorm then caused a flash flood event, which led to the containment of the fire. Both airborne ash from the fire and the runoff from the flash flood entered into the Santa Barbara Basin (SBB). Here, we present the results from aerosol, river, and seawater studies of black carbon and metal delivery to the SBB associated with the fire and subsequent flash flood. On day 11 of the Thomas Fire, aerosols sampled under the smoke plume were associated with high levels of PM2.5, levoglucosan, and black carbon (average: 49 μg/m3, 1.05 μg/m3, and 14.93 μg/m3, respectively) and aerosol metal concentrations were consistent with a forest fire signature. Metal concentrations in SBB surface seawater were higher closer to the coastal perimeter of the fire (including 2.22 nM Fe) than further off the coast, suggesting a dependence on continental proximity rather than fire inputs. On days 37–40 of the fire, before, during, and after the flash flood in the Ventura River, dissolved organic carbon, dissolved black carbon, and dissolved metal concentrations were positively correlated with discharge allowing us to estimate the input of fire products into the coastal ocean. We estimated rapid aerosol delivery during the fire event to be the larger share of fire‐derived metal transport compared to runoff from the Ventura River during the flood event.
High‐Resolution C‐Isotope, TOC and Biostratigraphic Records of OAE 1a (Aptian) From an Expanded Hemipelagic Cored Succession, Western Tethys: A New Stratigraphic Reference for Global Correlation and Paleoenvironmental Reconstruction
Authors: Castro José M. , Ruiz‐Ortiz Pedro A. , de Gea Ginés A. , Aguado Roque , Jarvis Ian , Weissert Helmut , Molina José M. , Nieto Luis M. , Pancost Richard D. , Quijano María L. , Reolid Matías , Skelton Peter W. , López‐Rodríguez Carmina , Martínez‐Rodríguez Rafael 
Published: February 2021

AbstractA high‐resolution carbonate C‐isotope stratigraphy for the Aptian is presented for the Cau core (Spain). The biostratigraphically calibrated C‐isotope stratigraphy of the core is used to refine the previously defined C‐isotope segments of the Aptian. Thirteen C‐isotope segments have been identified and correlated, and further subdivisions are presented. Correlation with other sections worldwide demonstrates the robustness of the C‐isotope stratigraphy of the Cau core. The studied succession includes a continuous record of the early Aptian Oceanic Anoxic Event (OAE 1a). Its onset has been studied at an ultrahigh‐resolution scale (0.2–0.5 kyr spacing), revealing a succession of sharp δ13Ccarbnegative spikes, interpreted as a record of pulses of volcanism and methane emissions. The largest spike was rapid (<10 kyr) and marks the base of OAE 1a, which occurs within a longer‐term falling δ13Ccarbtrend. The C‐isotope profile across OAE 1a perfectly records the negative (C3/Ap3), positive (C4/Ap4), steady (C5/Ap5), and positive (C6/Ap6) segments that were defined from Cismon (Italy) and subsequently identified worldwide. The Ap7 to Ap14 segments record a C‐isotope negative excursion, coupled with high TOC contents, probably related to regional paleogeography. The links with global environmental changes, episodes of widespread deposition of organic matter, and ultimately to major volcanic episodes are discussed. We propose the Cau core as a new reference section for the Aptian, and specifically for OAE 1a, based on its expanded and well‐preserved sedimentary, geochemical and biotic archives, which provide further insights into the environmental and biotic changes that occurred during this time interval.
Chronic modafinil therapy ameliorates depressive-like behavior, spatial memory and hippocampal plasticity impairments, and sleep-wake changes in a surgical mouse model of menopause
Authors: Yan Yu-Dong , Chen Yu-Qing , Wang Chen-Yao , Ye Chen-Bo , Hu Zhen-Zhen , Behnisch Thomas , Huang Zhi-Li , Yang Su-Rong 
Published: February 2021

AbstractDepression, cognitive deficits, and sleep disturbances are common and often severe in menopausal women. Hormone replacement cannot effectively alleviate these symptoms and sometimes elicits life-threatening adverse reactions. Exploring effective therapies to target psychological problems is urgently needed. In this work, we developed a mouse model of menopause by bilateral ovariectomies (OVXs) and investigated whether menopausal mental symptoms can be ameliorated by psychostimulant modafinil (MOD) as well as explored the underlying mechanisms. At ~3 weeks after OVXs, mice got daily intraperitoneal administrations of MOD at the beginning of the active phase. Several behavioral tests and electroencephalogram (EEG) recordings were conducted. Electrophysiological and immunohistochemical experiments were carried out to evaluate the synaptic plasticity and neurogenesis, respectively. We found that chronic MOD administration in OVX mice significantly decreased immobility time. The spatial memory performance of OVX mice improved significantly in response to MOD administration in the Morris water-maze test. The OVX mice were characterized by an attenuation of hippocampal synaptic transmission and synaptic long-term potentiation and had fewer 5-ethynyl-2′-deoxyuridine-labeled cells in the dentate gyrus, which were restored after MOD administration. Antagonists of dopamine D1 and D2 receptors and GABAA receptor agonists were involved in MOD-exerted anti-depressant actions and augments of hippocampal neurogenesis in OVX mice. Moreover, night-dosed MOD therapy significantly promoted the night-time delta-band EEG power during wakefulness and the day-time rapid eye movement sleep amount, which were significantly reduced by OVXs. Collectively, these findings suggest that MOD is a promising therapeutic candidate for menopausal women.
Phase 1 open-label study of panobinostat, lenalidomide, bortezomib + dexamethasone in relapsed and relapsed/refractory multiple myeloma
Authors: Laubach Jacob P. , Tuchman Sascha A. , Rosenblatt Jacalyn M. , Mitsiades Constantine S. , Colson Kathleen , Masone Kelly , Warren Diane , Redd Robert A. , Grayson Dena , Richardson Paul G. 
Published: February 2021

AbstractAdditional therapeutic options are needed for relapsed and refractory multiple myeloma (RRMM). We present data from a phase 1b, open-label, dose-escalation study (NCT01965353) of 20 patients with RRMM (median age: 63 years [range: 50–77]) and a median of four prior regimens (range: 2–14); 85% had refractory disease (lenalidomide [80%]; bortezomib [75%]; lenalidomide and bortezomib [50%]). Patients received a median of six cycles (range: 1–74) of panobinostat (10 or 15 mg), lenalidomide 15 mg, bortezomib 1 mg/m2, and dexamethasone 20 mg (pano-RVd). Median follow-up was ~14 months. Six dose-limiting toxicities were reported (mostly hematological); maximum tolerated dose of panobinostat (primary endpoint) was 10 mg. Most common adverse events (AEs) were diarrhea (60%) and peripheral neuropathy (60%); all grade 1/2. Grade 3/4 AEs occurred in 80% of patients and included decreased neutrophil (45%), platelet (25%) and white blood cell (25%) counts, anemia (25%) and hypophosphatemia (25%). No treatment-related discontinuations or mortality occurred. In evaluable patients (n = 18), overall response rate was 44%, and clinical benefit rate was 61%. Median duration of response was 9.2 months; progression-free survival was 7.4 months; overall survival was not reached. Pano-RVd proved generally well-tolerated and demonstrated potential to overcome lenalidomide and/or bortezomib resistance.
Changes in patient-reported outcomes in light chain amyloidosis in the first year after diagnosis and relationship to NT-proBNP change
Authors: D’Souza Anita , Brazauskas Ruta , Dispenzieri Angela , Panepinto Julie , Flynn Kathryn E. 
Published: February 2021

AbstractWe conducted a prospective cohort study in newly diagnosed systemic light chain (AL) amyloidosis patients (N = 59) to study patient-reported outcomes (PROs) through the first year. The median age was 68 years with 42% female, 8% Black, and 78% lambda subtype. Organ involvement was cardiac in 66%, renal in 58%, with 25% having 3 or greater organs involved. Between baseline and 3 months, all PROMIS®-29 domain scores worsened by 0.4–4.1 points except anxiety which improved by 2.1 points. By 1 year, scores improved compared to the greatest decline at 3 months, most statistically significant for global physical health, physical function, and fatigue. On stage-adjusted survival analysis, in addition to baseline global physical and mental health, domains measuring physical function, fatigue, anxiety, depression, and social roles were associated with 1-year survival. At 1 year, PROMIS measures were associated with NT-proBNP changes and hematologic response. Among patients with an NT-proBNP response, the improvement was seen in physical function, social roles, global mental health, and anxiety. Among patients with an NT-proBNP progression, worsening was seen with anxiety, depression, sleep, and global mental health. Measuring and tracking PROs in patients with AL amyloidosis is important and these important outcomes can be used as correlative endpoints in clinical care/research.
A clinical perspective on plasma cell leukemia; current status and future directions
Authors: Tuazon Sherilyn A. , Holmberg Leona A. , Nadeem Omar , Richardson Paul G. 
Published: February 2021

AbstractPrimary plasma cell leukemia (pPCL) is an aggressive plasma cell disorder with a guarded prognosis. The diagnosis is confirmed when peripheral blood plasma cells (PCs) exceed 20% of white blood cells or 2000/μL. Emerging data demonstrates that patients with lower levels of circulating (PCs) have the same adverse prognosis, challenging the clinical disease definition, but supporting the adverse impact of circulating PCs. The cornerstone of treatment consists of combination therapy incorporating a proteasome inhibitor, an immunomodulatory agent, steroids, and/or anthracyclines and alkylators as part of more-intensive chemotherapy, followed by consolidative autologous hematopoietic cell transplantation in eligible patients and then maintenance therapy. Monoclonal antibodies are also currently being evaluated in this setting with a strong rationale for their use based on their activity in multiple myeloma (MM). Due to limited therapeutic studies specifically evaluating pPCL, patients with pPCL should be considered for clinical trials. In contrast to MM, the outcomes of patients with pPCL have only modestly improved with novel therapies, and secondary PCL arising from MM in particular is associated with a dismal outlook. Newer drug combinations, immunotherapy, and cellular therapy are under investigation, and these approaches hopefully will demonstrate efficacy to improve the prognosis of pPCL.