bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanostructured Ethosomal Gel Loaded with Arctostaphylosuva-Ursi
Extract; In-Vitro/In-Vivo Evaluation as a Cosmeceutical Product for Skin
Rejuvenation
Authors: Khan Haji Muhammad Shoaib , Javed Nayla , Ijaz Shakeel , Akhtar Naveed 
Published: July 2021

Background:
Arctostaphylosuva-ursi(AUU) being rich in polyphenols and arbutin is
known to have promising biological activities and can be a potential candidate as a cosmaceutical.
Ethosomes encourage the formation of lamellar-shaped vesicles with improved solubility and entrapment
of many drugs including plant extracts.

Objective:
The objective of this work was to develop an optimized nanostructured ethosomal gel
formulation loaded with AUU extract and evaluated for skin rejuvenation and depigmentation.

Methods:
AUU extract was tested for phenolic and flavonoid content, radical scavenging potential,
reducing power activity, and in-vitro SPF (sun protection factor) estimation. AUU loaded 12 formulations
were prepared and characterized by SEM (Scanning Electron Microscopy), vesicular size,
zeta potential, and Entrapment Efficiency (%EE). The optimized formulation was subjected to noninvasive
in-vivo investigations after incorporating it into the gel system and ensuring its stability
and skin permeation.

Results:
Ethosomal vesicles were spherical in shape and Zeta size, zeta potential, PDI (Polydispersity
Index), percentages of EE and in-vitro skin permeation of optimized formulation (F3) were
found to be 114.7nm, -18.9mV, 0.492,97.51±0.023%,and 79.88±0.013% respectively. AUU loaded
ethosomal gel formulation was stable physicochemically and exhibited non-Newtonian behavior
rheologically. Moreover, it significantly reduced skin erythema, melanin as well as sebum level
and improved skin hydration and elasticity.

Conclusion:
A stable AUU based ethosomal gel formulation could be a better vehicle for phytoextracts
than conventional formulations for cosmeceutical applications such as for skin rejuvenation
and depigmentation.
The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and
Therapy of Central Nervous System Diseases
Authors: Chen Hongxiu , Ma Di , Yue Feixue , Qi Yajie , Dou Manman , Cui Liuping , Xing Yingqi 
Published: July 2021

:
Hypoxia-inducible factor-1 (HIF-1) is a heterodimer protein composed of an oxygenregulated
functional subunit, HIF-1α, and a structural subunit, HIF-1β, belonging to the basic helixloop-
helix family. Strict regulation of HIF-1 protein stability and subsequent transcriptional activity
involves various molecular interactions and is primarily controlled by post-transcriptional modifications.
Hypoxia, owing to impaired cerebral blood flow, has been implicated in a range of central
nervous system (CNS) diseases by exerting a deleterious effect on brain function. As a master oxygen-
sensitive transcription regulator, HIF-1 is responsible for upregulating a wide spectrum of target
genes involved in glucose metabolism, angiogenesis, and erythropoiesis to generate the adaptive response
to avoid, or at least minimize, hypoxic brain injury. However, prolonged, severe oxygen deprivation
may directly contribute to the role-conversion of HIF-1, namely, from neuroprotection to
the promotion of cell death. Currently, an increasing number of studies support the fact HIF-1 is involved
in a variety of CNS-related diseases, such as intracranial atherosclerosis, stroke, and neurodegenerative
diseases. This review article chiefly focuses on the effect of HIF-1 on the pathogenesis
and mechanism of progression of numerous CNS-related disorders by mediating the expression of
various downstream genes and extensive biological functional events and presents robust evidence
that HIF-1 may represent a potential therapeutic target for CNS-related diseases.
Wound Image Quality From a Mobile Health Tool for Home-Based Chronic Wound Management With Real-Time Quality Feedback: Randomized Feasibility Study
Authors: Zhang Jia , Mihai Carina , Tüshaus Laura , Scebba Gaetano , Distler Oliver , Karlen Walter 
Published: July 2021

Background
Travel to clinics for chronic wound management is burdensome to patients. Remote assessment and management of wounds using mobile and telehealth approaches can reduce this burden and improve patient outcomes. An essential step in wound documentation is the capture of wound images, but poor image quality can have a negative influence on the reliability of the assessment. To date, no study has investigated the quality of remotely acquired wound images and whether these are suitable for wound self-management and telemedical interpretation of wound status.

Objective
Our goal was to develop a mobile health (mHealth) tool for the remote self-assessment of digital ulcers (DUs) in patients with systemic sclerosis (SSc). We aimed to define and validate objective measures for assessing the image quality, evaluate whether an automated feedback feature based on real-time assessment of image quality improves the overall quality of acquired wound images, and evaluate the feasibility of deploying the mHealth tool for home-based chronic wound self-monitoring by patients with SSc.

Methods
We developed an mHealth tool composed of a wound imaging and management app, a custom color reference sticker, and a smartphone holder. We introduced 2 objective image quality parameters based on the sharpness and presence of the color checker to assess the quality of the image during acquisition and enable a quality feedback mechanism in an advanced version of the app. We randomly assigned patients with SSc and DU to the 2 device groups (basic and feedback) to self-document their DU at home over 8 weeks. The color checker detection ratio (CCDR) and color checker sharpness (CCS) were compared between the 2 groups. We evaluated the feasibility of the mHealth tool by analyzing the usability feedback from questionnaires, user behavior and timings, and the overall quality of the wound images.

Results
A total of 21 patients were enrolled, of which 15 patients were included in the image quality analysis. The average CCDR was 0.96 (191/199) in the feedback group and 0.86 (158/183) in the basic group. The feedback group showed significantly higher (P<.001) CCS compared to the basic group. The usability questionnaire results showed that the majority of patients were satisfied with the tool, but could benefit from disease-specific adaptations. The median assessment duration was <50 seconds in all patients, indicating the mHealth tool was efficient to use and could be integrated into the daily routine of patients.

Conclusions
We developed an mHealth tool that enables patients with SSc to acquire good-quality DU images and demonstrated that it is feasible to deploy such an app in this patient group. The feedback mechanism improved the overall image quality. The introduced technical solutions consist of a further step towards reliable and trustworthy digital health for home-based self-management of wounds.
Transitions in Technology-Mediated Cardiac Rehabilitation and Self-management: Qualitative Study Using the Theoretical Domains Framework
Authors: Tadas Shreya , Pretorius Claudette , Foster Emma J , Gorely Trish , Leslie Stephen J , Coyle David 
Published: July 2021

Background
An acute cardiac incident is a life-changing event that often necessitates surgery. Although surgery has high success rates, rehabilitation, behavioral changes, and self-care are critical to long-term health. Recent systematic reviews have highlighted the potential of technology in this area; however, significant shortcomings have also been identified, particularly with regard to patient experience.

Objective
This study aims to improve future systems and to explore the experiences of cardiac patients during key phases after hospitalization: recuperation, initial rehabilitation, and long-term self-management. The key objective is to provide a holistic understanding of behavioral factors that impact people across these phases, understand how experiences evolve over time, and provide user-centered recommendations to improve the design of cardiac rehabilitation and self-management technologies.

Methods
Semistructured interviews were conducted with people who attended rehabilitation programs following hospitalization for acute cardiac events. Interviews were developed and data were analyzed via the Theoretical Domains Framework, a pragmatic framework that synthesizes prior theories of behavioral change.

Results
Three phases that arise posthospitalization were examined, namely, recuperation, rehabilitation, and long-term self-management. Through these phases, we describe the impact of key factors and important changes that occur in patients’ experiences over time, including the desire for and redefinition of normal life, the need for different types of formal and informal knowledge, the benefits of safe zoning and connectedness, and the need to recognize capability. The use of the Theoretical Domains Framework allows us to show how factors that influence behavior evolve over time and to identify potential sources of tension.

Conclusions
This study provides empirically grounded recommendations for the design of technology-mediated cardiac rehabilitation and self-management systems. Key recommendations include the use of technology to support a normal life, leveraging social influences to extend participants’ sense of normality, the use of technology to provide a safe zone, the need to support both emotional and physical well-being, and a focus on recognizing capability and providing recommendations that are positive and reinforce this capability.
EFFICACY OF SEVELAMER CARBONATE IN COMBINATION WITH EDIBLE SOURCES IN HYPERPHOSPHATEMIA CONDITION ASSOCIATED WITH CHRONIC KIDNEY DISORDER
Authors: P. SHLINI , ROY DIKSHA , SINGH RICHA 
Published: July 2021

Objective: The main objective of the study was to discover a suitable dietary source of plant origin which can be recommended alongside the medication in case of hyperphosphatemia.
Methods: The 2 plant samples chow chow (Sechiumedule) and bitter gourd (Momordica carantia) and two seed samples-Flax seeds (Linumusitatissimum) and Chia seeds (Salvia hispanica) were selected for the study. The samples were extracted using methanol. The filtrate obtained was used for dialysis studies under different conditions. Inorganic phosphate was estimated in each of the conditions.
Results: The study indicated perturbation in the absorption of phosphate with the selected plant samples as talked about in the following study. The extreme concentration of phosphate among the four diverse picked plant sources was seen in bitter gourd, which was found to be 0.4686 µmoles/ml. A minimal measure of 0.0693 µmoles/ml of phosphate was found in chia seeds. Chow chow ended up being the best one in hyperphosphatemia condition as the amount of phosphate removed by it along with the drug, sevelamer carbonate, was calculated to be the maximum (0.0561 µmoles). It was followed by chia seeds (0.0429 µmoles) and flax seeds (0.0420 µmoles).
Conclusion: The present study concentrates on the impact of various samples of plant extraction that can act on the phosphate absorption in the intestine by the procedure of dialysis.
PREDICTION OF ANTI-ALZHEIMER’S ACTIVITY OF FLAVONOIDS TARGETING CD33 THROUGH IN-SILICO APPROACH
Authors: S. AKILA , S. MALAR VIZHI , P. VIJAYALAKSHMI , A. CLARA MARY , M. RAJALAKSHMI 
Published: July 2021

Objective: Alzheimer's disease (AD) is a progressive, fatal brain disorder that would be putting a growing strain on health and social care systems. Present anti-AD agents are limited in their application due to their adverse effects, toxicity, and limited targets in AD pathology. As a result, it is important to develop an AD-fighting compound. Some flavonoids (such as kaempferol, myricetin, quercetin, and syringetin) have been shown to be effective in the treatment of Alzheimer's disease.
Methods: We chose 284 flavonoids from the NPACT database for molecular docking studies in order to examine their binding interactions with the Alzheimer target protein CD33.
Results: These compounds exhibited significant docking interactions with a variety of targets implicated in the pathogenesis of AD. We chose the top three compounds (Rutin, Morin, and,4,4'-Trihydroxydihydrochalcone) based on the scoring parameter.
Conclusion: These compounds exhibited favorable pharmacokinetic properties, indicating that they could be attractive drug candidates for the treatment of Alzheimer's disease.
PROTECTIVE INFLUENCE OF FISETIN ON COGNITIVE AND BIOCHEMICAL INDICES IN N-NITROSODIETYHLAMINE TREATED DROSOPHILA MELANOGASTER
Authors: SOFIA JENEFER , SUBRAMANIAN PERUMAL 
Published: July 2021

Objective: The current investigation is intended to investigate the protecting influence of fisetin on cognitive, as well as biochemical indices in N-Nitrosodiethylamine (NDEA, a potent carcinogen), treated Drosophila melanogaster.
Methods: D. melanogaster is used as a model organism for this investigation. Experimental flies are divided into four groups. Group 1–control, group 2-flies were treated with 0.01% NDEA in food medium, group 3–flies treated with 0.01% NDEA and 0.01% fisetin and group 4-flies were treated with 0.01% fisetin alone. Behavioural abnormalities (negative geotaxis, phototaxis, smell and taste chemotaxis, hygrotaxis and thermotaxis) were quantitatively observed to be deviated in NDEA treated flies compared to control but were tend to be normalized in fisetin treated flies.
Results: The contents of protein carbonyl, thiobarbituric acid reactive substance (TBARS), protein thiol and lipid peroxides were noticeably augmented in NDEA treated flies than control flies and correspondingly tend to normalize in fisetin treated groups. Further, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidise (GPX) and reduced glutathione (GSH) were decreased in NDEA treated group and were significantly increased (p<0.05) in fisetin treated groups.
Conclusion: Fisetin, a bioactive phytochemical could act as a potent antioxidant and as well exhibit antiproliferative characteristics. Our investigation indicates that this could prevent the abnormalities in behaviour and redox homeostasis during carcinogenesis in D. melanogaster.
LA CONCEPCIÓN DE FAMILIA EN NIÑOS DE CONTEXTOS SOCIOECONÓMICOS VULNERABLES: UN ESTUDIO EMPÍRICO
Authors: Leibovich de Figueroa Nora , Marconi Aracelli , Minichello Claudia 
Published: July 2021

El objetivo del presente trabajo es la descripción de la concepción que tienen los niños en torno a conceptos estructurantes de la realidad social como lo es el concepto de familia en contextos de vulnerabilidad psicosocial. Deseamos mostrar nuevos modos de acercamiento y evaluación en Psicología asi como aportar categorías de análisis a través de un enfoque Ecoevaluativo. Nos interesa ofrecer una descripción de la concepción de familia que tienen los niños entre 9 y 11 años que habitan contextos de pobreza, caracterizados por la vulnerabilidad psicosocial y que asisten a comedores comunitarios. Consideramos que la familia es uno de los contextos más relevantes en el desarrollo humano y que la experiencia personal en torno a la vida familiar afecta la interpretación que los integrantes de la misma tienen sobre este concepto. Esto abre entonces un abanico de nuevas perspectivas para la investigación de la concepción de familia desde la palabra de los mismos actores sociales involucrados, en este caso los niños. A partir de un minucioso análisis cualitativo de los gráficos de familia realizados por los pequeños, se presentará una descripción de las categorías obtenidas considerando los datos más significativos y comunes a todos los dibujos.
¿LA ACTITUD ROMÁNTICA HACIA EL AMOR ES LA QUE PREDOMINA CUANDO SE ELIJE PAREJA?
Authors: Kasanzew Alexis , López Pell Andrea , Brasca Luciana , Fernandez M.S. , Prudente Irene 
Published: July 2021

Mediante un diseño descriptivo se estudiaron estilos de amor y vínculos de apego romántico en una muestra intencional de alumnos de psicología. El objetivo fue conocer los estilos predominantes mediante las escalas de Actitudes sobre el Amor y Tipos de Apego en contextos románticos. También se recolectó información sobre los vínculos románticos de los participantes. Los resultados muestran una preferencia por el estilo eros de amor, en coincidencia con estudios previos. Sin embargo, el tipo de apego romántico más frecuentefue el temeroso, en clara disidencia a trabajos previos publicados sobre el tema. Entre los resultados obtenidos destaca que el 50% de la muestra expresó su duda hacia la posibilidad de casarse con una persona que reúna los requisitos añorados pero de la cual no se estuviese enamorado, cuando la negativa hubiese sido la respuesta esperable acorde al estilo de amor predominante.
EFECTOS TERAPÉUTICOS POSITIVOS A TRAVÉS DEL AUMENTO DEL OPTIMISMO
Authors: López Pell Andrés Fernando , Kasanzev Alexis , López María Beatriz 
Published: July 2021

El optimismo parece ser un constructo significativo en cuanto permitiría predecir variables de notable importancia clínica. La psicología positiva plantea que el incremento del optimismo influye de manera significativa en la disminución de la sintomatología psicopatológica. De ser esto así, se podrían optimizar los efectos de la psicoterapia mediante un plan para incrementar el optimismo. Con el objetivo de probar esta hipótesis, se diseñó un estudio experimental con pacientes que recibían psicoterapia cognitiva clásica. Para evaluar cambios en los síntomas psicopatológicos se utilizó la escala SCL-90-R. Los resultados mostraron una disminución significativa en variables como somatizaciones, ansiedad fóbica y hostilidad a favor del grupoexperimental en comparación con el grupo control. Por lo tanto, este plan para aumentar el optimismo parece producir una optimización de la psicoterapia cognitiva al disminuir la intensidad de los síntomas en los pacientes.
EVALUACIÓN DE LAS COMPETENCIAS COGNITIVAS Y SOCIALES DE NIÑOS QUE HAN ESTADO EN SITUACIÓN DE CALLE
Authors: Cuadro A. , Barg G. , Navarrete I. , Suero M. 
Published: July 2021

En el siguiente estudio se busca una aproximación exploratoria a la población de los niños y niñas en situación de calle de Montevideo. Se trabajo con 27 niños de ambos sexos de entre 7 y 13 años. Se consideraron las variables sociodemográficas y se evaluó el desarrollo neuropsicológico, incluyendo la utilización del lenguaje oral, la relación con el código escrito, las habilidades de razonamiento lógico-matemático, el funcionamiento cognitivo general y la exploración de algunos indicadores psicopatológicos. Los resultados muestran que se trata de una población con un alto nivel de carencias y vulnerabilidades, y una importante presencia de trastornos comportamentales. En el aspecto cognitivo, se encuentra algún nivel de efectividad en la ejecución intelectual de operaciones no verbales. En las tareas verbales, se comprobaría un déficit significativo por el escaso desarrollo general del lenguaje. Esto tendría consecuencias negativas en la inserción escolar así como en la capacidad de auto-regulación del comportamiento.
SOBRE LA FUNDACIÓN DEL ESPACIO ANALÍTICO: ACTUALIDAD DEL LEGADO DE SIGMUND FREUD
Authors: Veríssimo de Posadas Laura 
Published: July 2021

El trabajo se propone refl exionar sobre las condiciones que hacen posible un proceso psicoanalítico, desde la mirada que nos legara Sigmund Freud. Se discurre acerca de la creación de un espacio, delimitado por un encuadre, al que se compara con la escena onírica, con sus reglas propias y, a la vez, como ella, permeado por la realidad externa. Es allí que la función analítica puede ejercerse apoyada, también, en la atención fl otante y la regla de abstinencia que siguen considerándose pilares fundamentales del método. Desde estas afirmaciones se toma posición en los debates actuales respecto a la práctica analítica. Una breve viñeta ilustra algunas de las ideas planteadas.
PERFIL EPIDEMIOLÓGICO DAS FRATURAS DE FACE: UMA REVISÃO DE LITERATURA
Authors: DE SOUZA VIANA RODRIGO , Barros Jackeline Nogueira de Paula 
Published: July 2021

As fraturas de face são um problema de saúde pública que afeta a qualidade de vida dos indivíduos que sofreram esse agravo. Sabendo-se da importância dos estudos epidemiológicos para o enfrentamento desse problema, este trabalho teve como objetivo traçar o perfil epidemiológico das fraturas de face, contribuindo assim, para a elaboração de políticas públicas mais eficazes e tratamento adequado. Para isso foi ralizada uma revisão de literatura nas principais bases de dados, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrievel System Online (MEDLINE) e Bibliografia Brasileira de Odontologia (BBO) através da Biblioteca Virtual em Saúde (BVS) e diretamente pela interface da Literature Analysis (PubMed/MEDLINE), nos últimos 20 anos, contemplando populações, culturas e faixas etárias heterogêneas. Observou-se que o sexo masculino foi o mais acometido e sua incidência foi maior entre os jovens, as principais etiologias foram às agressões físicas e os acidentes de transito sobretudo com o envolvimento de motocicletas associado ao uso de álcool e drogas. Os ossos nasais e a mandíbula foram as estruturas que sofreram mais fraturas e o tratamento mais utilizado foi a redução fechada. Neste contexto, faz-se necessário medidas ao combate às desigualdades sociais e desemprego, incentivo à educação e intensificação das leis de trânsito.
Palavras-Chave: Traumatismo facial; Epidemiologia; Fratura
IMPLANTES IMEDIATOS, E SEUS DEFEITOS PERI-IMPLANTARES (GAP) PREENCHIDOS COM O USO DE BIOMATERIAS SINTÉTICOS.
Authors: Miranda Bruno Pires , Silva Eduardo Moreira da , Miranda Helba Pires , Kalil Marcos da Veiga , Senna Marcos Antônio Albuquerque de 
Published: July 2021

A colocação de implantes osseointegráveis requer volume ósseo adequado, porém, a extração de dentes leva a diferentes padrões de remodelaç ão e reabsorção óssea. A reabsorção do rebordo alveolar tem sido considerada uma consequência inevitável da extração dentária e pode ser um problema significativo em Implantodontia. Após a extração dentária, mesmo com a instalação de implantes imediatos, o sítio desdentado do processo alveolar sofre substancial modelagem óssea, com a diminuiç ão das dimensões da crista alveolar. Após a inserção de um implante em um local de extração fresco, um defeito marginal (GAP) ocorre, frequentemente, entre o rebordo e a superfície do implante, A fim de superar esse problema e para facilitar a formaç ão de osso no defeito marginal, vários processos de enxerto têm sido utilizados, associados ou não ao uso de membranas de barreira, bem como diversos tipos de substitutos ósseos que podem ser utilizados para tal procedimento. Esse trabalho tem por objetivo revisar e discutir a literatura relacionada ao uso de biomateriais sintéticos para preenchimento desses defeitos que se formam ao redor de implantes instalados em alvéolos frescos. No entanto, ainda não existe um biomaterial ideal que possua todas as pro- priedades desejáveis. Além disso, o volume de osso residual deve ser avaliado antes da extração de dentes, de modo que os cirurgiões possam utilizar técnicas diferentes para preservar o osso alveolar.
Palavras-chave: implantes dentários, transplante ósseo, materiais biocompatíveis.