bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Legal Impacts of The Convention for The Conservation of Southern Bluefin Tuna on The Optimum Utilization and Sustainability of Highly Migratory Fish
Authors: Wartini Sri 
Published: February 2021

The sustainability of southern Bluefin tuna (SBT) is very important, since the SBT as one of the highly migratory fish which is very valuable. Because of that, the SBT are exploited tremendously and it caused serious decline of the population. Due to the reasons, the aim of the paper is to examine comprehensively the legal impacts of the Convention for The Conservation of Southern Bluefin Tuna (CCSBT) on the optimum utilization and sustainability of the SBT as one of highly migratory fish, There are two problems questions that are proposed, namely, first, how is the role of the Commission of CCSBT in the optimum utilization and sustainable conservation of the SBT. Second, how is the legal impacts of the CCSBT to the conduct of the Member States to obey the obligations of the CCSBT in order to utilize and to maintain the sustainability of the SBT in sustainable manner. The result of the paper finds that there is positive legal impacts of the CCSBT to the Member States’ conduct in order to materialize the optimum utilization and sustainability of the SBT, though, there are still some challenges. Keywords: conservation, highly migratory fish, optimum utilization, southern tuna Bluefin, sustainable manner.Southern Bluefin Tuna (SBT), as one of the highly migratory fish, is very valuable due to the high demand inthe international market. Hence, the SBT is exploited tremendously and it caused a severe decline in thepopulation. To maintain the sustainability utilization of SBT, the role of the Commission on the CCSBT isimperative. The objective of the research is to examine conceptually the legal impacts of the Convention forthe Conservation of Southern Bluefin Tuna (CCSBT) on the optimum utilization and sustainability of the SBT.It is a normative juridical research by applying conceptual and statutory approaches. The results of theresearch indicates that: first, the role of the Commission of CCSBT in the optimum utilization and thesustainability of the SBT is very significant: second, there are positive legal impacts of the CCSBT to theconduct of the Member States to comply with provisions of the CCSBT; third, the legal impacts of CCSBT areable to oblige the Member States to perform their obligations, however, there are still some challenges tomaterialize the objective of the CCSBT.Keywords: conservation; highly migratory fish; optimum utilization; southern tuna bluefin; sustainability.
A Remunicipalization Idea on Water Management in DKI Jakarta Province
Authors: Setiadi Wicipto , Pratiwiningrum Aprilia Zul 
Published: February 2021

Since 1997, water privatization has existed but there is no significant progress on water management in Jakarta. Many households don’t have access to clean water due to the leakage and outdated pipes as well as the non-legal contract between PT. Aetra Air Jakarta and PT. Palyja. The contract was not in accordance with Article 33 (3) of the 1945 Constitution of the Republic of Indonesia and not in a fair tender. The research problems focus on: what actions are taken by theJakarta Government to take over the water management in Jakarta and Can theremunicipalization policy be used as a model in Jakarta? This research uses thenormative legal method. In order to address the issue, the Jakarta Governmentapplies the remunicipalization on water management. The government hasassigned the task force to find the ideal solution. The task force comes up with 3alternatives: status quo, contract termination, processed to the civil court.Keywords: Remunicipalization; DKI Jakarta Province; Water Privatization.
ANALISIS FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP KINERJA PEGAWAI PT. KERETA API INDONESIA (PERSERO) DAOP 5 PURWOKERTO DENGAN PARTIAL LEAST SQUARE
Authors: Jajang Jajang , Supriyanto Supriyanto , Putra Dimas Eka 
Published: February 2021

In this research, PLS method is applied to analyze which factor are affect employee performance in PT. Kereta Api Indonesia (Persero) DAOP 5 Purwokerto based on variables that are research factors that is employee performance, work motivation, leadership, training, work enviroment and corporate culture through the indicator which are then analyzed. From analysis using a PLS method with 6 variables of research, it was found that R-square value work of motivation variables of 77,00% with good assessments defined by construct variable of leadership, training, work enviroment and corporate culture while another 23% is described by other variables outside this research. The value of R-square on employee performance variables of 66,00% with good enough assessment criteria described by the work of motivation, where as another 34% is described by other variables outside this research model.
Systematic expression and bioinformatics analysis of fibrinogen-like protein 1 in human cancer and its co-expression network
Authors: Wang Qian , Chen Shu-zhen , Zhang Hua-wei 
Published: February 2021

Abstract
Background

Fibrinogen-like protein 1 was initially found in a study on hepatocellular carcinoma and it is overexpressed in human cell lines and rats. Recently, investigations have focused on fibrinogen-like protein 1 dysfunction in carcinogenesis. Our study aims to determine the role of fibrinogen-like protein 1 and its possible role in human carcinoma.
Methods

Fibrinogen-like protein 1 expression in different neoplasms was assessed by Oncomine. Fibrinogen-like protein 1 coexpression networks in various cancers were established using Coexpedia. Finally, we investigated the potential functions of fibrinogen-like protein 1 with gene ontology and pathway enrichment analyses with the FunRich V3.
Results

Fibrinogen-like protein 1 was overexpressed in several kinds of neoplasms at the transcriptional level. Coexpression networks showed that fibrinogen-like protein 1 regulates immune response and lipid related pathways.
Conclusions

The present results offer the possibility that fibrinogen-like protein 1 acts as a therapeutic target for some types of cancers and may take part in carcinogenesis.
Finite Element Simulations for Entropy Generation Measurement in Single Phase Flow of Water Based Nanofluid Filled in Square Cavity under Appliance of Inclined Magnetic field
Authors: Bilal S. 
Published: February 2021

Abstract
Current communication candidly explicates entropy generation process generated due to natural convective heating in square enclosure saturated with nanofluid. Water is used as base fluid and Cu particles are induced to depict enhancement in thermo physical characteristics. Natural convection in enclosure is produced by providing temperature difference on boundaries. Upper wall is provided uniform temperature while rest of walls are kept cold. Impermeability and non-slip conditions are imposed on all walls. Mathematical structuring of considered problem is manifested via continuity, momentum and energy equations under appliance of inclined magnetic field. Thermo physical properties of nanoparticles along with base liquids are used during mathematical structuring. Finite element procedure is adopted to elucidate flow features. Discretization of domain is done by applying hybrid meshing. Velocity and isothermal plots are drawn against concerning parameters. Comprehensive description of energy generation by measuring variation in magnetic, viscous, total and thermal irreversibility’s are also presented. Cut lines representing velocity field in horizontal and vertical direction are also drawn to predict flow behavior at different locations.
Characteristics of Brain Structure in HIV Male Patients with Syphilis Co-Infection: A Cross-Sectional Study.
Authors: Qi Yu , Wang Yuan-Yuan , Wang Wei , Liu Xu-Ze , Liu Jing , Guo Yi-Fan , Ma Pei-Hong , Li Xing , Zhang Xiao-Dong , Yu Wen , Liu Jiao-Jiao , Liu Ming-Ming , Li Rui-Li , Li Hong-Jun 
Published: February 2021

Abstract
Background To investigate the effect of syphilis infection on the microstructure of white matter (WM) in HIV-infected male patients through comparing the differences of WM between HIV-infected male patients with and without syphilitic infection using diffusion tensor imaging (DTI).Methods 27 HIV-infected male patients with current syphilis or a history of syphilis (HIV+/syphilis+) and 29 HIV-infected male patients without syphilis co-infection history (HIV+/syphilis-) were enrolled. All patients received DTI and comprehensive neuropsychological assessment. Clinical data were compared between the two groups with T-test, Mann-Whitney U Test and Chi-square Test. Tract-based spatial statistics (TBSS) was adopted to analyze the DTI metrics. Multiple linear regression analysis was conducted to investigate the relationships between DTI metrics and clinical variables and cognitive performance. Results In the HIV+/syphilis+ group, decreased AD was found in the right superior corona radiata (SCR-R) and body of corpus callosum (BCC); increased RD was found in the bilateral posterior corona radiata (PCR), the right posterior thalamic radiation (PTR-R), the left SCR (SCR-L), splenium of corpus callosum (SCC) and BCC; decreased FA was found in multiple regions. AD in BCC was negatively correlated with CD4/CD8 ratios. AD in SCR-R was positively correlated with CD4/CD8 ratios. Patients in HIV+/syphilis+ group had a lower score in complex motor skills (CMS). RD in SCC and SCR-L was negatively correlated with CMS; RD in PTR-R was positively correlated with CMS. AD in SCR-R was positively correlated with CMS. Conclusions Compared with patients simply infected with HIV, the integrity of WM is more seriously impaired in HIV-infected patients with syphilis co-infection, and it may accelerate the impairment of cognitive function.
Symptomatic Lumbar Intradural Spinal Lipoma– Case Report
Authors: Davarski Atanas , Apostolov Georgi 
Published: February 2021

Abstract
Background

Intradural lipomas (IL) not associated with spina bifida in the lumbar region are rare and isolated cases have been reported in the literature. The current paper presents a case of a patient who suffers from intradural lipoma without spinal dysraphism in the lumbar region. We also made a brief literature review.
Case presentation:

A 31-year-old patient suffered from back pain resistant to medication for more than a year. Few weeks prior to hospitalization, the pain irradiated to the feet associated with numbness, weakness and urinary dysfunction. Upon hospitalization, partial cauda equina syndrome was diagnosed that included radiculopathy along L4-S1 nerve roots, predominantly on the left side, decreased tendon reflexes, left-sided fibular and tibial paresis. Partial urinary retention was also present. Magnetic resonance tomography demonstrated a lesion located in the dorsal intradural space at the level of L3–L4 vertebra that had fat-equivalent ovoid form compressing and dislocating the components of the dural sac ventrally. Laminectomy of L3 and L4 vertebrae was performed. We encountered an intradural tumor formation with a yellowish colour and that was adherent to the nerve roots of cauda equina. After microsurgical dissection of the nerve roots, the tumor was partially resected. The histological examination confirmed the diagnosis of lipoma. Postoperatively, the neurological status improved significantly. The pain syndrome, motor symptoms and pelvic reservoir dysfunction were reduced.
Conclusions

In cases with intradural lipomas, the earliest possible surgical decompression with maximal safe resection of the lesion is a therapeutic method of choice that results in significant improvement or complete recovery of the neurological deficit.
TREM2 is a prognostic biomarker and correlates in immune infiltrates in kidney renal papillary cell carcinoma and liver hepatocellular carcinoma
Authors: Xiang bin wen , Fang Sha , Ding peng yan , Liu min nuo , Wu chao hua , Yu Haijun 
Published: February 2021

Abstract
Background: TREM2 was identified as a marker for tumor-associated macrophages (TAMs) and monocytes. However, there is limited information concerning the TREM2 mRNA levels correlated with the outcome and tumor-infiltrating lymphocytes in different cancers.Methods: To explore the expression pattern and prognostic value of TREM2 in pan-cancer, We use multiple databases, including ONCOMINE, PrognoScan, Kaplan-Meier Plotter, GEPIA, and TIMER. we investigated the correlations between TREM1 expression and immune infiltration in cancers, especially kidney renal papillary cell carcinoma (KIRP), and liver hepatocellular carcinoma (LIHC)Results: According to the results from Oncomine and TIMER datasets, in a general way, TREM2 mRNA expression is higher in the majority of the tumor and is lower in lung cancer, compared with normal adjacent tissues. A high expression level of TREM2 was beneficial to the survival of LIHC patients. Both in KIRP and LIHC, TREM2 expression levels showed significant positive correlations with infiltrating levels of macrophages and dendritic cells. It also correlated with diverse immune marker sets. We can also find that TREM2 expression was modestly associated with CD8+T cells in KIRP. However, it is related to the Treg in LIHC.Conclusions: TREM2 may be a prognostic marker in the multitudinous tumor. Furthermore, TREM2 may interact with immune infiltration to influence patient survival in cancers like LIHC and KIRP.
Microbiota Modulation to Reduce Cardiovascular Risk in HIV Patients: A Systematic Review
Authors: Pablo Villoslada-Blanco , Patricia Pérez-Matute , A Oteo José 
Published: February 2021

Abstract
Background: human immunodeficiency virus (HIV) infection is associated with premature and accelerated aging linked to the development of several co-morbidities, such as cardiovascular events, even after controlling for traditional cardiovascular risk factors. Since both traditional and “novel” factors are involved in the increased cardiovascular risk (CVR) observed in HIV-infected patients, new biomarkers could be needed to diagnose, evaluate and prevent the evolution of these events. Furthermore, since microbiota disturbance is involved in HIV-associated co-morbidities, all strategies focused on reversing or modulating gut microbiota (GM) composition and/or functionality could be of interest. In this context, a solid scientific evidence based on well-designed clinical trials is needed to support the use of prebiotics, probiotics, symbiotics and fecal transplantation (FT) to modify GM in HIV-infected patients and, therefore, to reduce the incidence of cardiovascular disease (CVD) in this population.
Methods: a search in PubMed has been carried out covering all clinical trials (Clinical Trial filter) including adult humans (19+ years) and whose results have been published in the last 10 years. Besides, the results obtained from ClinicalTrials.gob have been included and described in the present review Thus, we have reviewed the main results obtained from 3 clinical trials concerning the effects of prebiotics, 25 concerning probiotics, 6 concerning symbiotics and 4 concerning FT.
Results: none of the trials included in this review investigated if these compounds were able to reduce cardiovascular events in HIV patients.
Conclusions: the huge variability observed in the type of compound used, the dose and the length of administration, makes difficult to analyse the results as a proper meta-3 analysis and, therefore, to adopt general recommendations. Thus, there is an urgent need to investigate in this direction through robust and well-designed clinical trials.
Clinical Association Between Behçet Syndrome, Cytopenia, and Acquired Trisomy 8: a New Clinical Syndrome?
Authors: Shen Yan , Luo Dan , Ma Hai-fen , Cai jian-fei , Zou Jun , Bao Zhi-jun , Guan Jian-long 
Published: February 2021

Abstract
Objectives: Behçet syndrome (BS) is heterogeneous with clinical variability across ethnicities and geographic locations. This study analyzed the clinical characteristics of BS associated with cytopenia and trisomy 8.Methods: This was a retrospective study of Chinese BS patients in the Shanghai Behçet’s disease database who were diagnosed with cytopenia and trisomy 8 between October 2012 and April 2019. All subjects fulfilled the International Study Group (ISG) criteria or the International Criteria for Behçet’s Disease (ICBD).Results: Twenty-one patients with BS had cytopenia with trisomy 8; 16 (16/21, 76.2%) were diagnosed with myelodysplastic syndrome (MDS). Compared with 1,147 patients with BS without cytopenia, patients with BS and trisomy 8/cytopenia were more likely to be female (23.8% vs 51.8%,p= 0.011), older (37.9 ± 12.8 vs 45.1 ± 12.0, p = 0.007), have fewer skin lesions (33.3% vs 56.7%,p= 0.033), fever (52.4% vs 1.1%, p < 0.001), have higher C-reactive protein, have higher erythrocyte sedimentation rate (ESR), and display a higher rate of gastrointestinal (GI) ulceration (61.9% vs 9.2%, p < 0.001). By contrast, they had a lower leukocyte count, lower hemoglobin levels, and a lower platelet count (p < 0.05 for all comparisons). Ulcers in the ileocecal region were more frequently seen in intestinal patients with BS with trisomy 8 than in patients with BS without cytopenia (100.0% vs 41.8%; p = 0.002). Compared with 54 patients with MDS without BS symptoms, those with BS and trisomy 8-cytopenia were more likely to be female (23.8% vs 70.4%, p< 0.001) and younger (37.9 ± 12.8 vs 67.2 ± 12.4, p= 0.001). In the follow-up, three patients with BS with trisomy 8 (3/21, 14.3%) died, which is a higher rate than in patients with BS (5/1147, 0.44%) and much lower than in patients with MDS (13/54, 24.1%).Conclusions: The data on patients with BS with cytopenia and trisomy 8 were different from BS or MDS in epidemiology, clinical performance, and prognosis. BS with cytopenia and acquired trisomy 8 may be a new clinical syndrome.
New Insights Into Hematological, Serum Biochemical and Histopathological Toxicity of Bisphenol a on Bighead Carp (Aristichthys Nobils) Under Long-Term Exposure
Authors: Akram Rabia , Iqbal Rehana , Hussain Riaz , Ali Muhammad 
Published: February 2021

Abstract
Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide and is frequently used in dental sealants, water bottles, food and beverage packaging. Due to persistant application, BPA has become potential threat to variety of organisms including public health. In this study for the first time 80 bighead carps were randomly placed in different four groups (A-D). Fish in groups (B-D) were treated with BPA 60 days while fish in group A served as control group. Body weight, absolute and relative weight of different visceral organs of fish exposed to higher concentrations (1500 µg/L) of BPA decreased significantly (p < .05). Results on proximate analysis showed significantly decreased in crude proteins, lipid contents and moisture contents in muscles while increased ash contents. Red blood cells count, hemoglobin concentration, lymphocytes and monocytes were significantly decreased while leukocytes counts and neutrophil counts was significantly increased in treated fish. Results on different serum biochemistry parameters like serum albumin and total proteins decreased significantly (p < .05) while alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), urea creatinine, glucose, cholesterol and lactate dehydrogenase (LDH) increased significantly (p < .05) in treated fish. Histopathological ailments like pyknosis, degeneration glomeruli, increased Bowman’s space, ceroid formation in kidneys while ceroid formation, hemorrhages, pyknosis, karyorrhexis, karyolysis, binucleated hepatocytes, nuclear hypertrophy and eccentric nuclei in liver were observed in treated fish. Histological observation of ndifferent sections of brain of treated fish exhibited degenerated neurons in cerebellum, lipofuscin deposition, microgliosis, necrotic neurons, inflammatory cell and severe hemorrhage. Results on light microscopic observation of different sections of heart of bighead carp revealed necrosis, inflammatory reaction, neutrophilic myocarditis and hemorrhages. In conclusion, it is suggested that BPA induces adverse effects on physical, blood-biochemical parameters and histopathological changes in multiple visceral tissues of exposed fish.
Oxycodone Enhances the Effects of Metformin Therapy in Mices With Painful Diabetic Neuropathy Induced by Alloxan
Authors: Askari Zahra , Boskabadi Seyed Javad , Mahdizade Amirhossein , Ataee Ramin 
Published: February 2021

Abstract
Background

DN (diabetic neuropathy) is a common disorder and two thirds of diabetic patients have clinical or subclinical neuropathy. Pain in DN can be spontaneous or stimulus induced and aggravate in nights. µ-opioid receptor make weak-reply to an antinociceptive effect of opioid agonist but κ-opioid receptors create antinociceptive response appropriately.
Methods

Diabetic animals were treated intraperitoneally for 3weeks in 9 groups including different doses of oxycodone and codeine with constant dose of metformin (200mg/kg). The normal saline group was considered as a negative control group and diabetic group as positive control. After 3 weeks Hot plate and tail flic test were done and fasting blood glucose was measured. After that Animals were sacrificed and oxidative stress biomarkers including lipid peroxidation, protein carbonyl content, and glutathione content were measured in brain and liver isolated mitochondria.
Conclusion

In this study finding demonstrated that Oxycodone (high dose 8mg/kg) with effect on both µ-opioid receptor and κ-opioid receptor significantly enhances the effects of metformin therapy in mices with painful diabetic neuropathy. In addition, opioid drugs induced stress oxidative and MDA formation in brain and liver.As well as, in diabetic mices, glucose level in all drug groups significantly decreased in compared to positive diabetic group.
The New Direction of Senolytic Drug Research Should Be on Cancer Prevention, Adjuvant Therapies in Cancer and Healthy Senescence in Cancer Survivors (Senolytics and Cancer)
Authors: Tanriverdi Ozgur , Turkcu Ummuhani Ozel 
Published: February 2021

Abstract
In cases where cellular senescence does not function properly, the use of drugs called senolytics in the prevention of chronic aging-related disorders such as cancer, diabetes and cardiovascular diseases has become a very interesting topic. There are studies showing that senolytic drugs can be used for the purpose of preventing cancer, preventing recurrence in individuals diagnosed with cancer, and delaying multimorbidity situations that may develop as long-term side effects of anti-cancer treatments. This article has been prepared with the aim of reminding general information about senolytic drugs and cellular senescence due to the fact that there are many controversial researches in the field of oncology in the future