bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB‐fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts
Authors: Tauziède‐Espariat Arnault , Sievers Philipp , Larousserie Frédérique , Benzakoun Joseph , Guillemot Delphine , Pierron Gaëlle , Duchesne Mathilde , Uro‐Coste Emmanuelle , Roux Alexandre , Vasiljevic Alexandre , Fenouil Tanguy , Meyronet David , Mokhtari Karima , Polivka Marc , Rousseau Audrey , Bost‐Bezeaud Frédérique , Akoury Samir , Pallud Johan , Benevello Chiara , Hasty Lauren , Gareton Albane , Lechapt Emmanuèle , Chrétien Fabrice , Blauwblomme Thomas , Beccaria Kévin , Puget Stéphanie , Sahm Felix , Varlet Pascale ,   the RENOCLIP‐LOC
Published: July 2021

AbstractFET:CREB fusions have been described in a variety of tumors from various phenotypes. Recently, these fusion transcripts were reported in intracranial tumors, variably named intracranial mesenchymal myxoid tumors or angiomatoid fibrous histiocytomas. Controversy remains concerning the terminology for these tumors. Here, we report 11 cases of central nervous system mesenchymal tumors with proven FET:CREB fusion. Most DNA methylation profiles were not classifiable using the Heidelberg Brain Tumor or Sarcoma Classifier (v11b4/v12.2). However, by using unsupervised t‐SNE and hierarchical clustering analyses, six of the cases constituted a distinct cluster. The remaining four tumors showed no obvious relation to any of the other referenced classes but were close to the clusters of extra‐CNS angiomatoid fibrous histiocytomas (n = 1), clear cell sarcomas (n = 1), or solitary fibrous tumors (n = 2). Our findings confirm that intracranial FET:CREB‐fused tumors do not represent a single molecular tumor entity, although most samples clustered close to each other, indicating the existence of a distinct epigenetic group that could potentially be partially masked by the low number of cases included. Further analyses are needed to characterize intracranial FET:CREB fused‐defined tumors in more detail.
I agreed to go because........examining the Agency of Children within a phenomenon conceptualised as trafficking in Ghana
Authors: Koomson Bernard , Manful Esmeranda , Dapaah Jonathan Mensah , Yeboah Eric Henry 
Published: July 2021

AbstractThe legal and policy framework on child trafficking is dismissive of children's agency and regards them as vulnerable personalities. This paper examines the scope of children's agency in their transportation to other communities for fishing in Ghana. Using a phenomenological design, 17 child returnees' views were elicited on their movement for fishing activities. Findings revealed that children's agentive capabilities progressed primarily from consent giving to negotiation. Highlighting the relational and material context within which children's agency unfolds, the study suggests that it is erroneous to generally ascribe the discursive label of ‘innocence’ to children who are considered as trafficked.
Recurrence after complete mesocolic excision for right‐sided colon cancer: post hoc sensitivity analyses—early recurrence, surgery by specialist and dissection in the mesocolic plane
Authors: Bertelsen Claus Anders , Neuenschwander Anders Ulrich , Kleif Jakob 
Published: July 2021

AbstractAimThe aim was to investigate whether the previously reported causal treatment effect of complete mesocolic excision on the risk of recurrence was biased by inclusion of patients with potentially undiagnosed disseminated disease at the time of surgery, by non‐specialist surgery, or caused by mesocolic plane dissection.MethodA population of 1069 patients, 813 undergoing conventional resection and 256 complete mesocolic excision for colon cancer during the period 2008–2013, was stepwise reduced in the following order by excluding patients with recurrence diagnosed within 6 months of the resection, having surgery performed by a non‐specialist without supervision, and specimens assessed as not being mesocolic plane dissection. The primary outcome measure was risk of recurrence after 5.2 years using competing risk analyses.ResultsThe absolute risk reduction of complete mesocolic excision was 6.0% (95% CI 1.8–10.2; P = 0.0049) after excluding patients with recurrence within 6 months of resection, 6.1% (95% CI 1.9–10.4; P = 0.0045) after excluding non‐specialist surgery, and 7.5% (95% CI 2.9–12.0; P = 0.0013) after the exclusion of patients whose specimens were assessed as dissections not being performed in the mesocolic plane.ConclusionThe absolute risk reduction of recurrence after complete mesocolic excision for right‐sided colon cancer in our previous study was not biased by potentially undiagnosed disseminated disease at the time of surgery or non‐specialist surgery, and was not solely caused by dissection in the mesocolic plane. Central vascular dissection with central lymphadenectomy seems a major factor for better oncological results.
Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease
Authors: Li Qing , Shen Chenye , Liu Zhaolin , Ma Yuanyuan , Wang Jinghui , Dong Hongtian , Zhang Xiaoshuang , Wang Zishan , Yu Mei , Ci Lei , Sun Ruilin , Shen Ruling , Fei Jian , Huang Fang 
Published: July 2021

AbstractObjectivesParkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive and selective degeneration of dopaminergic neurons. Microglial activation and neuroinflammation are associated with the pathogenesis of PD. However, the relationship between microglial activation and PD pathology remains to be explored.Materials and MethodsAn acute regimen of MPTP was administered to adult C57BL/6J mice with normal, much reduced or repopulated microglial population. Damages of the dopaminergic system were comprehensively assessed. Inflammation‐related factors were assessed by quantitative PCR and Multiplex immunoassay. Behavioural tests were carried out to evaluate the motor deficits in MPTP‐challenged mice.ResultsThe receptor for colony‐stimulating factor 1 inhibitor PLX3397 could effectively deplete microglia in the nigrostriatal pathway of mice via feeding a PLX3397‐formulated diet for 21 days. Microglial depletion downregulated both pro‐inflammatory and anti‐inflammatory molecule expression at baseline and after MPTP administration. At 1d post‐MPTP injection, dopaminergic neurons showed a significant reduction in PLX3397‐fed mice, but not in control diet (CD)‐fed mice. However, partial microglial depletion in mice exerted little effect on MPTP‐induced dopaminergic injuries compared with CD mice at later time points. Interestingly, microglial repopulation brought about apparent resistance to MPTP intoxication.ConclusionsMicroglia can inhibit PD development at a very early stage; partial microglial depletion has little effect in terms of the whole process of the disease; and microglial replenishment elicits neuroprotection in PD mice.
Carbol fuchsin stain enhances detection of poly‐(d, l‐lactide‐co‐glycolide) microspheres in exenatide extended‐release cutaneous injection‐site foreign body reaction
Authors: Flugrad Rebecca , Hoerres Derek , Googe Paul B 
Published: July 2021

AbstractInjection of high‐viscosity fluids into subcutaneous tissues may lead to a granulomatous reaction called sclerosing lipogranuloma (SL). Poly‐(d,l‐lactide‐co‐glycolide) (PLG or PLGA) microspheres are used as vehicles for extended‐release drugs. Here we describe the histopathologic features of a case of SL induced by exenatide extended‐release injections, and the staining pattern of PLG microspheres and microsphere remnants with carbol fuchsin.
Signals of resilience and change in tidepool fish communities on the Pacific coast of Vancouver Island, Canada
Authors: Green John M. , Dunbrack Robert L. , Bates Amanda E. 
Published: July 2021

AbstractAimOcean warming and marine heatwaves have emerged as strong predictors of biodiversity change in coastal systems. Here, we test for systematic change in tidepool fish communities between recent and historical data sets, which include the North Pacific marine heatwave of 2014–2016.LocationPeriodic sampling occurred since 1966 at study site isolated from human activities on the Pacific west coast of Vancouver Island, Canada.MethodsRepeated fish sampling at seven wave‐exposed rocky shore tidepools was conducted on 8 (historical: 1966–1993) and 5 (recent: 2012–2016) occasions during low tide using methods that capture all individuals present (including cryptic and rare species). Species were subsequently identified using standard taxonomic approaches and abundances recorded. These data comprised the basis for analyses of both community‐level and species‐specific responses to test for differences in the historical and recent time periods.ResultsWe did not detect systematic increases or declines in species density, total abundance of fishes within tidepools and community similarity between historical and recent sampling events in high‐intertidal pools. However, fish communities from low‐shore pools decreased in the number of species present, overall abundance and community similarity. Those species lost from the lower pools were non‐resident rare species typical of subtidal environments. By contrast, a warm‐affinity crevice kelpfish was observed only recently. We also found that six species had higher or lower abundances between historical and recent sampling events, and one species occurred at higher vertical heights.Main conclusionFish communities in high‐intertidal pools were resilient between historical and recent sampling periods, and lacked evidence of invasion. However, some signals of community and species changes were evident in the lower shore. Overall, these communities may reach a threshold with ongoing ocean warming and continued monitoring is required to reveal any major changes as they unfold.
The labour‐oriented perspective of validating non‐formal and informal learning: Lessons learned from three Dutch case studies
Authors: Duvekot Ruud , Onstenk Jeroen 
Published: July 2021

AbstractOrganisations that support employees to take responsibility and ownership for their lifelong learning can reinforce the return on investment in human resources development (HRD). In this way, learning is a process driven by a dialogue on personal development and steered by HRD. The result of this dialogue is mutually beneficial to employers and employees. Based on the reflection of employees in three Dutch cases, an answer was sought to the questions of how the Validation of Non‐formal and Informal Learning (VNIL) system fits into the operationalisation of dialogues on personal development within a labour‐oriented perspective and what this means for the application of Validation of Non‐formal and Informal Learning (VNIL) in the HRD of public and private organisations. The aim is gaining insight into the linkage of personal qualities and development opportunities within public and private organisations. The extent to which organisations are able to activate dialogues using VNIL not only colours HRD strategies but also results in an open dialogue on and shared ownership of lifelong learning. Both dialogue and shared ownership reinforce the organisation's mission. Lessons learned from Dutch cases highlight available approaches and opportunities for employers and employees when activating the labour‐oriented perspective of the VNIL.
Variation in generation time reveals density regulation as an important driver of pace of life in a bird metapopulation
Authors: Araya‐Ajoy Yimen G. , Niskanen Alina K. , Froy Hannah , Ranke Peter Sjolte , Kvalnes Thomas , Rønning Bernt , Le Pepke Michael , Jensen Henrik , Ringsby Thor Harald , Sæther Bernt‐Erik , Wright Jonathan 
Published: July 2021

AbstractGeneration time determines the pace of key demographic and evolutionary processes. Quantified as the weighted mean age at reproduction, it can be studied as a life‐history trait that varies within and among populations and may evolve in response to ecological conditions. We combined quantitative genetic analyses with age‐ and density‐dependent models to study generation time variation in a bird metapopulation. Generation time was heritable, and males had longer generation times than females. Individuals with longer generation times had greater lifetime reproductive success but not a higher expected population growth rate. Density regulation acted on recruit production, suggesting that longer generation times should be favoured when populations are closer to carrying capacity. Furthermore, generation times were shorter when populations were growing and longer when populations were closer to equilibrium or declining. These results support classic theory predicting that density regulation is an important driver of the pace of life‐history strategies.
Intraspecific variation in longevity of Drosophila prolongata (Diptera: Drosophilidae) under solitary and group conditions
Authors: Kudo Ayumi 
Published: July 2021

AbstractConsiderable variations in behavior and physiology exist among sexes and strains of species. The amount and allocation of energy resources can affect the health and survival of individuals. If an individual devotes a large amount of energy to interact with other conspecifics, the resources may become too scarce to maintain their physical condition, which could reduce longevity. In this study, I examined the interactive effects of sex, strain, and the presence of conspecifics on adult longevity using four strains of Drosophila prolongata. This species shows a large intraspecific variation in behavior and morphology among isofemale strains. Under solitary conditions, longevity was significantly different among strains for both sexes. The effects of same‐sex conspecifics on adult longevity were also highly variable between the sexes and among strains. When exposed to conspecifics, the longevity of males of a hyper‐aggressive strain was more notably decreased than that of females of the same strain or either sex of other less aggressive strains. These results indicate that differences in the balance of costs and benefits of social interactions lead to differences in adult longevity under group conditions between the sexes and among strains within the same species.
Christ’s Love as the New Face of Christian Apologetics in India
Authors: Wetsah Kerio 
Published: July 2021

AbstractThe new face of Christian apologetics emphasizes advocating the gospel through a praxis‐oriented perspective of Christ’s love. The new face does not show superiority or advantages, but manifests the benefit of our faith in Christ’s love to the world. This article argues that reigniting Christ’s love in a self‐believing world not only exemplifies but also fulfils the purpose of faith in Christ. This is the greatest evidence of apologetics we can give to our friends of other faiths. Considering the multireligious world, which has turned into a global village, we must ask how Christ’s love can be advocated without hurting the sentiments of another religion. This question takes on greater importance in a multireligious context like India, where Christians are a minority. In such a setting, no matter how much we seek to remain exclusive, advocacy is tangible only through our manifestation of Christ’s love transcending ethnic, gender, religious, political, and economic barriers. The hallmark of our advocacy should be that our presence is a blessing in a multireligious context.
God Is Love – The Experience of the Just, Compassionate, and Merciful God
Authors: Sauca Ioan 
Published: July 2021

AbstractIn 2022, the 11th Assembly of the World Council of Churches (WCC) is to gather in Karlsruhe, Germany, around the theme “Christ’s love moves the world to reconciliation and unity.” This article offers reflections on understanding the theme in a holistic way against the background of the work undertaken in the WCC on trinitarian and incarnational theology, and the reconciliation of all in Christ that is expressed in the WCC document “Towards a Common Understanding and Vision of the WCC.” It goes on to offer reflections from an Orthodox perspective on the just, merciful, and compassionate God that we experience as love.
Doubt and Hope
Authors: Shmaliy Vladimir 
Published: July 2021

AbstractThe article examines the theme of the forthcoming assembly of the World Council of Churches (WCC) in the context of previous assemblies – in particular, of Orthodox participation in them. More specifically, it examines the question of why the word “church” is absent in the themes of the assemblies of the WCC and how this is related to the problem of Christian unity. The article shows that due to the impossibility of offering a unanimous witness to belonging to one visible church, the WCC emphasizes that divided Christians are united in Christ. The article considers the question of how the ecumenical theology of “the world,” as reflected in assembly themes and its relationship to Christian unity, has changed during the history of the WCC, and Orthodox perspectives on the relationship between the church and the world. Finally, it refers to the challenges associated with an emphasis on the theme of “ecumenism of love.”
DNA marker analysis of flowering time, semi‐dwarf, fertility restorer, and brown midrib genes in sorghum (Sorghum bicolor [L.] Moench)
Authors: Kawahigashi Hiroyuki , Yonemaru Jun‐ichi , Kiyosawa Atsushi , Mizuno Hiroshi , Kasuga Sigemitsu 
Published: July 2021

AbstractDNA markers for the genes for flowering time (Ma1/SbPRR37, Ma2/SbEHD1, Ma3/SbPhyB, Ma4/SbCO, Ma5/SbPhyC, and Ma6/SbGHD7), semi‐dwarfism (dw1 and dw2), fertility restorers (Rf1, Rf2, Rf5, and partial A1 mitochondrial sequence) and cytoplasmic–nuclear male sterile (CMS), and brown midrib (bmr‐2, bmr‐6, and bmr‐18) were developed in this study. These markers and previously published DNA markers for dw3 were used to analyze sorghum cultivars used in breeding programs in Japan and traditional landraces from the National Institute of Agricultural Sciences (NIAS) sorghum core collection. Agronomically useful mutations were effectively detected in the cultivars by the DNA markers. Most of the mutation types for flowering and semi‐dwarfism were detected in sorghum cultivars, but only the dominant‐type allele of SbEHD1 and SbPhyB for flowering was detected in the NIAS collection. Fertility restorers and CMS were rarely detected in NIAS collection. Agronomically useful traits such as early flowering and semi‐dwarfism became combined in the modern cultivars by phenotypic evaluation for the adaptation of harvesting to the temperate zones. Fertility restorers and CMS were introduced for F1 hybrid breeding. These phenotypes are often recessive, so information on the alleles responsible would be helpful for sorghum breeding. We expect these DNA markers to facilitate and improve the efficiency of F1 sorghum breeding programs.
Histopathological and molecular profiling of lung adenocarcinoma skin metastases reveals specific features
Authors: Forest Fabien , Laville David , Habougit Cyril , Da Cruz Vanessa , Casteillo François , Yvorel Violaine , Bard‐Sorel Sandrine , Godard William , Picot Tiphanie , Tiffet Olivier , Perrot Jean‐Luc , Péoc'h Michel 
Published: July 2021

AimsLittle is known regarding the histopathological and molecular features of lung adenocarcinoma skin metastases. Our study is the largest, to our knowledge, to comprehensively explore these to date.Methods and resultsWe performed a retrospective cohort study analysing 42 lung adenocarcinoma skin metastasis samples obtained from a database of 2659 lung adenocarcinomas collected between 2010 and 2020. EGFR exon 19 deletion was detected in one patient and KRAS mutations were detected in 12 (33.3%) patients. The programmed cell death ligand 1 (PD‐L1) tumour proportion score was <1% in 27 patients, ≥1% and <50% in eight patients, ≥50% in six patients and not assessable in one patient. We showed that the predominant histopathological subtype is different from that at other metastatic sites (P = 0.024). Thyroid transcription factor I (TTF‐1) was more often negative in skin metastases compared to other sites (P < 0.001). The EGFR mutation rate tended to be lower for skin metastases compared to other sites (P = 0.079). Skin metastases were associated with a high rate of PD‐L1‐negative cases (P = 0.022).ConclusionOur work shows that the skin metastases of lung adenocarcinoma have a specific histopathological profile.
C. Radhakrishna Rao: A Century in Statistical Science
Authors: Kannan Nandini , Kundu Debasis 
Published: July 2021

SummaryIn this article, the authors provide a glimpse into the legendary career of centenarian Professor C. Radhakrishna Rao, a career that is inextricably linked to the history of modern statistics from Pearson and Fisher to the age of big data and Artificial Intelligence. A scientist of extraordinary vision, his ground‐breaking contributions have influenced not only the field of statistics, but the mathematical, social, biological and economic sciences. An outstanding researcher, a gifted and inspirational teacher who could make complex concepts come to life in a classroom and a mentor who demanded excellence from his students, Professor Rao continues to inspire generations of statisticians and scientists around the world.
Development and psychometric properties of a self‐report instrument for the assessment of sexual behaviour and concerns of people with mild intellectual disabilities (SEBECOMID‐S)
Authors: Gil‐Llario María Dolores , Flores‐Buils Raquel , Elipe‐Miravet Marcel , Fernández‐García Olga , Ballester‐Arnal Rafael 
Published: July 2021

AbstractBackgroundThis paper presents a description of the development and psychometric properties of a self‐report instrument for the assessment of sexual behaviour and concerns of people with mild intellectual disabilities (SEBECOMID‐S).Methods and proceduresThe study included 281 people with mild intellectual disabilities. The psychometric properties were examined through exploratory factorial analysis, descriptive statistics, and reliability indices.ResultsThe exploratory factor analyses offered a structure with three factors: concern about the appropriateness of their sexual behaviour, sexual practices performed, and safe sex practices. The model presents an excellent fit (χ2/df = 1.10, RMSEA = 0.019, CFI = 0.997, TLI = 0.995, and SRMR = 0.065). General test reliability was good (α = 0.77, Ω = 0.76).ConclusionsSEBECOMID‐S is a valid and reliable tool to obtain objective information about the sexual behaviour and concerns of people with mild intellectual disabilities. The use of this instrument will make it possible to adjust their training to their real experiences, making it more effective.