bluuebunny/crossref_metadata_2025_split huggingface dataset:
The African Dimension to the Anti-Federation Struggle, ca. 1950–53: “It has united us far more closely than any other question would have accomplished”
Authors: Power Rob 
Published: June 2021

AbstractThe documentary record of African opposition to the CAF (Central African Federation) has been the subject of renewed historiographical interest in recent years.2 This paper seeks to contribute to the existing debate in three principle ways. Firstly, it will show that opposition to the scheme was fatally undermined by the pursuits of two very distinct strands of NAC (Nyasaland African Congress) and ANC (African National Congress) political activism. In the second instance, it will show that this dissimilar political discourse produced contradictions that resulted in bypassing African objections. Thirdly, the paper will go a step farther, suggesting that the two respective anti-Federation campaigns not only undermined the efforts of both Congress parties to stop federation, but laid the path for future discord in the national dispensation then materialising.
Chief factors in Polish groups
Authors: REID COLIN D. , WESOLEK PHILLIP R. , LE MAÎTRE FRANÇOIS 
Published: June 2021

AbstractIn finite group theory, chief factors play an important and well-understood role in the structure theory. We here develop a theory of chief factors for Polish groups. In the development of this theory, we prove a version of the Schreier refinement theorem. We also prove a trichotomy for the structure of topologically characteristically simple Polish groups.The development of the theory of chief factors requires two independently interesting lines of study. First we consider injective, continuous homomorphisms with dense normal image. We show such maps admit a canonical factorisation via a semidirect product, and as a consequence, these maps preserve topological simplicity up to abelian error. We then define two generalisations of direct products and use these to isolate a notion of semisimplicity for Polish groups.
The Holy Month of Ramadan: Mass-Gathering Event Implications for Hospital Surge Capacity Planning in Saudi Arabia
Authors: Almalki Yousef , Hart Alexander , Issa Fadi , Hertelendy Attila J. , Mahon Selwyn , Voskanyan Amalia , Ciottone Gregory R. 
Published: June 2021

AbstractObjectives:The goal of this study is to determine the impact of the Holy Month of Ramadan on emergency department (ED) and hospital resource utilization in comparison to the time of Hajj and the rest of the year, so as to better define future resource needs of hospitals responding to events of this large size and duration.Methods:A retrospective chart review was conducted of electronic medical records, ED visits, and hospital admissions during Ramadan, Hajj, and all other months over a three-year period on the Hijra calendar (1438-1440) or Gregorian (2016-2019). Primary outcomes were the change in the number of ED visits, hospital admissions, and intensive care unit (ICU) admissions during Ramadan in comparison to during Hajj and other months. Secondary outcomes included mortality; number of surgeries by specialty; and admissions to cardiac, respiratory, orthopedic, and neurosurgery wards.Results:During the three years, ED visits increased during Ramadan by 83.0%, 74.8%, and 40.3%, respectively, when compared to non-Hajj, non-Ramadan months. Hospital admissions rose by 21.05%, 50.96% and 48.22%. Combined ED and in-hospital mortality rose by 15.21%, 21.47%, and 1.39%. While there was a large increase in ICU admissions during Ramadan of 1440 (May 2019), this was not a trend seen in other years. Despite there only being two years of data for comparison, there was a trend towards increased admissions to all specialty wards. There was an average 46.69% increase in admissions to the general surgery ward during Ramadan months compared to other months, a 31.06% increase in admissions to the orthopedic surgery ward, and a 44.05% increase in admissions to the cardiac care unit.Conclusions:Ramadan is associated with a significant increase in the population of Makkah (Mecca), Saudi Arabia. Despite this study only focusing on a three-year period, and some variables with only two years of data available, it demonstrates a significant increase in ED visits, hospital admissions, and mortality during Ramadan compared to non-Hajj/non-Ramadan months. During mass gatherings of this size, it would benefit local and regional hospital systems to devote increased resources to patient care, especially to the ED, to prevent morbidity and mortality.
Thunderstorms Producing Sferic‐Geolocated Gamma‐Ray Flashes Detected by TETRA‐II
Authors: Smith Deirdre , Trepanier Jill , Alnussirat Samer T. , Cherry Michael L. , Legault Marc D. , Pleshinger Donald J. 
Published: June 2021

AbstractThe terrestrial gamma‐ray flash (TGF) and Energetic Thunderstorm Rooftop Array (TETRA‐II) detected 22 X‐ray/gamma‐ray flash events associated with lightning between October 2015 and March 2019 across three ground‐based detector locations in subtropical and tropical climates in Louisiana, Puerto Rico, and Panama. Each detector array consists of a set of bismuth germanate scintillators that record X‐ray and gamma‐ray bursts over the energy range 50 keV–6 MeV (million electron volts). TETRA‐II events have characteristics similar to both X‐ray bursts associated with lightning leaders and TGFs: sub‐millisecond duration, photons up to MeV energies, and association with nearby lightning (typically within 3 km). About 20 of the 22 events are geolocated to individual lightning strokes via spatiotemporally coincident sferics. An examination of radar reflectivity and derived products related to events located within the Next Generation Weather Radar (NEXRAD) monitoring region indicates that events occur within mature cells of severe and non‐severe multicellular and squall line thunderstorms, with core echo tops which are at or nearing peak altitude. Events occur in both high lightning frequency thunderstorm cells and low lightning frequency cells. Events associated with high frequency cells occur within 5 min of significant lightning jumps. Among NEXRAD‐monitored events, hail is present within 8 km and 5 min of all except a single low‐altitude cold weather thunderstorm. An association is seen with maximum thunderstorm development, lightning jumps, and hail cells, indicating that the TETRA‐II X‐ray/gamma‐ray events are associated with the peak storm electrification and development of electric fields necessary for the acceleration of electrons to high energies.
Dietary interventions to improve body composition in men treated with androgen deprivation therapy for prostate cancer: a solution for the growing problem?
Authors: Umlauff Lisa , Weber Manuel , Freitag Nils , Fairman Ciaran M. , Heidenreich Axel , Bloch Wilhelm , Schumann Moritz 
Published: June 2021

Abstract
Background
Androgen deprivation therapy (ADT) has adverse effects on body composition, including muscle wasting and body fat accumulation, which may be attenuated by nutrition therapy. This systematic review summarises available evidence on the effects of dietary interventions on lean mass, fat mass and body mass index (BMI) in men treated with ADT for prostate cancer.

Methods
MEDLINE, Embase, Web of Science and ClinicalTrials.org were searched from inception through December 2020. We included all controlled trials evaluating effects of supplementation or dietary interventions on body composition in men with prostate cancer receiving continuous ADT. Methodological quality of the studies was assessed using the Cochrane Collaboration’s risk of bias tool. Meta-analysis was performed using a random effects model to calculate standardised mean differences between intervention and comparator groups. (PROSPERO; CRD42020185777).

Results
Eleven studies (n = 536 participants) were included. Seven studies investigated the effects of dietary advice interventions, e.g. individual or group counselling, and four studies included a nutritional supplement. Eight studies combined the dietary intervention with exercise. Nine studies reported sufficient data for inclusion in the meta-analysis. Dietary advice and supplementation interventions combined were not associated with significant changes in lean mass (0.05 kg; 95% CI: −0.17, 0.26; p = 0.674; n = 355), fat mass (−0.22 kg; 95% CI: −0.45, 0.01; p = 0.064; n = 336) or BMI (−0.16 kg*m−2; 95% CI: −0.37, 0.04; p = 0.121; n = 399). Dietary advice interventions alone were associated with a significant fat mass reduction (−0.29 kg; 95% CI: −0.54, −0.03; p = 0.028; n = 266).

Conclusions
Most studies were dietary advice interventions targeting caloric restriction, which showed the potential to reduce fat mass but did not increase lean mass in men treated with ADT. Future interventions should investigate whether a combination of dietary advice and protein supplementation with concomitant resistance exercise could counteract ADT-induced muscle wasting.
Antifungal susceptibilities of opportunistic filamentous fungal pathogens from the Asia and Western Pacific Region: data from the SENTRY Antifungal Surveillance Program (2011–2019)
Authors: Pfaller Michael A. , Carvalhaes Cecilia G. , Rhomberg Paul , Messer Shawn A. , Castanheira Mariana 
Published: June 2021

AbstractAntifungal surveillance is an important tool to monitor the prevalence of uncommon fungal species and increasing antifungal resistance throughout the world, but data comparing results across several different Asian countries are scarce. In this study, 372 invasive molds collected in the Asia-Western Pacific region in 2011–2019 were susceptibility tested for mold-active triazoles (isavuconazole, posaconazole, voriconazole, and itraconazole). The collection includes 318 Aspergillus spp. isolates and 53 non-Aspergillus molds. The MIC values using CLSI methods for isavuconazole versus Aspergillus fumigatus ranged from 0.25 to 2 mg l−1. Isavuconazole, itraconazole, posaconazole, and voriconazole acted similarly against A. fumigatus. The mold-active triazoles exhibited a wildtype phenotype to most of the Aspergillus spp. isolates tested (>94%), but poor activity against Fusarium solani species complex and Lomentospora prolificans. Voriconazole was most active against the Scedosporium spp. and posaconazole was most active against the Mucorales. In summary, isavuconazole displayed excellent activity against most species of Aspergillus and was comparable to other mold-active triazoles against non-Aspergillus molds.
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19
Authors: Sharma Dhavan , Zhao Feng 
Published: June 2021

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected nearly 118 million people and caused ~2.6 million deaths worldwide by early 2021, during the coronavirus disease 2019 (COVID-19) pandemic. Although the majority of infected patients show mild-to-moderate symptoms, a small fraction of patients develops severe symptoms. Uncontrolled cytokine production and the lack of substantive adaptive immune response result in hypoxia, acute respiratory distress syndrome (ARDS), or multiple organ failure in severe COVID-19 patients. Since the current standard of care treatment is insufficient to alleviate severe COVID-19 symptoms, many clinics have been prompted to perform clinical trials involving the infusion of mesenchymal stem cells (MSCs) due to their immunomodulatory and therapeutic properties. Several phases I/II clinical trials involving the infusion of allogenic MSCs have been performed last year. The focus of this review is to critically evaluate the safety and efficacy outcomes of the most recent, placebo-controlled phase I/II clinical studies that enrolled a larger number of patients, in order to provide a statistically relevant and comprehensive understanding of MSC’s therapeutic potential in severe COVID-19 patients. Clinical outcomes obtained from these studies clearly indicate that: (i) allogenic MSC infusion in COVID-19 patients with ARDS is safe and effective enough to decreases a set of inflammatory cytokines that may drive COVID-19 associated cytokine storm, and (ii) MSC infusion efficiently improves COVID-19 patient survival and reduces recovery time. These findings strongly support further investigation into MSC-infusion in larger clinical trials for COVID-19 patients with ARDS, who currently have a nearly 50% of mortality rate.
Exploring the nanomechanical concepts of development through recent updates in magnetically guided system
Authors: Khan Noor Saeed , Usman Auwalu Hamisu , Kaewkhao Attapol , Kumam Poom , Thounthong Phatiphat , Humphries Usa Wannasingha 
Published: June 2021

AbstractThis article outlines an analytical analysis of unsteady mixed bioconvection buoyancy-driven nanofluid thermodynamics and gyrotactic microorganisms motion in the stagnation domain of the impulsively rotating sphere with convective boundary conditions. To make the equations physically realistic, zero mass transfer boundary conditions have been used. The Brownian motion and thermophoresis effects are incorporated in the nanofluid model. Magnetic dipole effect has been implemented. A system of partial differential equations is used to represent thermodynamics and gyrotactic microorganisms motion, which is then transformed into dimensionless ordinary differential equations. The solution methodology is involved by homotopy analysis method. The results obtained are based on the effect of dimensionless parameters on the velocity, temperature, nanoparticles concentration and density of the motile microorganisms profiles. The primary velocity increases as the mixed convection and viscoelastic parameters are increased while it decreases as the buoyancy ratio, ferro-hydrodynamic interaction and rotation parameters are increased. The secondary velocity decreases as viscoelastic parameter increases while it increases as the rotation parameter increases. Temperature is reduced as the Prandtl number and thermophoresis parameter are increased. The nanoparticles concentration is increased as the Brownian motion parameter increases. The motile density of gyrotactic microorganisms increases as the bioconvection Rayleigh number, rotation parameter and thermal Biot number are increased.
Monitoring the haemodynamic response to visual stimulation in glaucoma patients
Authors: Re R. , Messenio D. , Marano G. , Spinelli L. , Pirovano I. , Contini D. , Colombo R. , Boracchi P. , Biganzoli E. , Cubeddu R. , Torricelli A. 
Published: June 2021

AbstractIn this paper, we used time-domain functional near infrared spectroscopy (TD-fNIRS) to evaluate the haemodynamic response function (HRF) in the occipital cortex following visual stimulation in glaucomatous eyes as compared to healthy eyes. A total of 98 subjects were enrolled in the study and clinically classified as healthy subjects, glaucoma patients (primary open-angle glaucoma) and mixed subjects (i.e. with a different classification for the two eyes). After quality check data were used from HRF of 73 healthy and 62 glaucomatous eyes. The amplitudes of the oxygenated and deoxygenated haemoglobin concentrations, together with their latencies with respect to the stimulus onset, were estimated by fitting their time course with a canonical HRF. Statistical analysis showed that the amplitudes of both haemodynamic parameters show a significant association with the pathology and a significant discriminating ability, while no significant result was found for latencies. Overall, our findings together with the ease of use and noninvasiveness of TD-NIRS, make this technique a promising candidate as a supporting tool for a better evaluation of the glaucoma pathology.
Technological basis of processing of serpentinite copper-gold ores in the Kyrgyz Republic
Authors: Nogaeva Kulzhamal , Alpiyev Yessil , Kozhonov Almaz , Korniyenko Valerii , Malanchuk Yevhenii 
Published: June 2021

Annotation.
The article is devoted to the development of an effective technology for processing serpentinite ores from the Bozymchak deposit in the Kyrgyz Republic. Based upon the analysis of mineralogical, physical and chemical parameters of the ore, the authors set reasons for the decrease in technological indicators of the existing concentrator and determine concentrating properties of the reviewed serpentinite resistant material by applying methods of intensifying the flotation process by using additional flotation collectors/depressors and introducing the process of mechanochemical activation of the pulp before flotation. In the proposed technological flowsheet, main requirements for the technological flowsheet and reagent suite of processing serpentinite ores are formed and it is acknowledged that an increase in the grinding size, introduction of the selective copper collector and additional depressor determines the prospects for improving the “reagent” component of determining factors of the set task. Materials of the article can be useful for mining and processing enterprises while involving resistant copper bearing, magnesian serpentinite ores in the processing in order to increase the raw material base of the existing mining and processing complex.
Shōnishin bei Kindern und Jugendlichen
Authors: Wernicke Thomas 
Published: July 2021

SummarySeit der Einführung der Akupunktur aus China nach Japan werden Kinder auch in Japan mit Akupunktur behandelt – daher der japanische Begriff Shōnishin (shōni = Kind; shin = Nadel/ Nadelung). Zu Beginn des 20. Jh. veränderte sich die Behandlungstechnik: Die einst invasive, stechende Akupunktur entwickelte sich zu einer sanften, nicht-invasiven Behandlungsmethode. Keine 100 Jahre später erfuhr Shōnishin eine nochmalige Weiterentwicklung und eröffnete durch die Verbindung der sino-japanischen Medizintradition mit dem heutigen Wissensstand der Entwicklungsphysiologie neue Behandlungsstrategien.
Do miRNAs Have a Role in Platelet Function Regulation?
Authors: Garcia A. , Dunoyer-Geindre Sylvie , Fontana P. 
Published: June 2021

AbstractMicroRNAs (miRNAs) are a class of non-coding RNAs known to repress mRNA translation and subsequent protein production. miRNAs are predicted to modulate many targets and are involved in regulating various cellular processes. Identifying their role in cell function regulation may allow circulating miRNAs to be used as diagnostic or prognostic markers of various diseases. Increasing numbers of clinical studies have shown associations between circulating miRNA levels and platelet reactivity or the recurrence of cardiovascular events. However, these studies differed regarding population selection, sample types used, miRNA quantification procedures, and platelet function assays. Furthermore, they often lacked functional validation of the miRNA identified in such studies. The latter step is essential to identifying causal relationships and understanding if and how miRNAs regulate platelet function. This review describes recent advances in translational research dedicated to identifying miRNAs' roles in platelet function regulation.
Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic Syndrome
Authors: Rohner Markus , Heiz Robert , Feldhaus Simon , Bornstein Stefan R. 
Published: June 2021

AbstractInsulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient insulin resistance remission. Treating insulin resistance with a molecular nutrition-centered approach shifts the treatment paradigm of Type 2 Diabetes from management to cure. This allows remission within five months, with a high efficiency rate of 85%. With molecular intermittent fasting a very efficient treatment for prediabetes and metabolic syndrome is possible, improving the non-alcoholic fatty liver disease (NAFL) state and enabling the body to lose weight in a sustainable manner.
Pre-Endoscopy Drink of Simethicone and N-Acetylcysteine Significantly Improves Visualization in Upper Gastrointestinal Endoscopy
Authors: Anikhindi Shrihari Anil , Kumar Ashish , Uedo Noriya , Singla Vikas , Anikhindi Akshay , Sharma Praveen , Bansal Naresh , Ranjan Piyush , Kumar Mandhir , Sachdeva Munish , Khare Shivam , Arora Anil 
Published: June 2021

Abstract
Introduction With the advancements in diagnostic and therapeutic upper gastrointestinal endoscopy (UGIE), clear mucosal visualization is essential to ensure optimal outcomes. Though routinely followed in Japan and Korea, pre-endoscopic preparation is seldom used in India. We evaluated the efficacy of a pre-endoscopic drink of N-acetylcysteine (NAC) and simethicone in improving mucosal visibility during UGIE.
Patients and Methods This study was a retrospective, investigator blind study with a case–control study design. Cases included patients who received a pre-endoscopy drink of NAC and simethicone in 100 mL water administered 10 to 30 minutes prior to UGIE. Controls only had mandatory fasting for 6 to 8 hours prior to UGIE. Propensity score matching was done to ensure comparability between the groups. Digital images were taken at six standard landmarks during UGIE and stored. A blinded investigator subsequently analyzed the images and rated the mucosal visibility on a 3-point scale. The difference in the mean mucosal visibility between the cases and controls was compared.
Results Mean mucosal visibility during UGIE was significantly better using NAC with simethicone as compared with no preparation at esophagus (1.14 [0.37] vs. 1.47 [0.62], p < 0.05), gastric fundus (1.10 [0.30] vs. 1.55 [0.64], p < 0.05), gastric body (1.22 [0.50] vs. 1.62 [0.73], p < 0.05), gastric antrum (1.13 [0.37] vs. 1.47 [0.62], p < 0.05), and duodenal bulb (1.13 [0.34] vs. 1.33 [0.56], p < 0.05). In distal duodenum, though visibility improved with NAC with simethicone, the difference was insignificant. There were no adverse events related to the pre-endoscopy drink.
Conclusion A pre-endoscopy drink of NAC with simethicone can significantly improve mucosal visibility during UGIE. It is safe, cheap, easily available and maybe considered for routine utilization for ensuring optimal endoscopic outcomes.
Prostatic Artery Embolization: An Alternative Treatment for Benign Prostatic Hyperplasia
Authors: Pike James F. , Abel William F. , Seckel Tyler B. , Schammel Christine M.G. , Flanagan William , Devane A. Michael 
Published: June 2021

Abstract
Purpose Prostatic artery embolization (PAE) has emerged as a minimally invasive alternative for patients with prostates >80 mL and has demonstrated lower morbidity rates. We sought to evaluate PAE at a single tertiary medical center. Methods A retrospective review of all patients who underwent PAE was completed. Demographic, clinicopathologic, procedure, and outcome data were collected to include international prostatic symptom score (IPSS) and quality of life (QoL) assessments. Results The pre-PAE mean prostate-specific antigen (PSA) was 8.4 ng/mL, mean prostate volume was 146.9 mL (9% >200 mL), and mean postvoid residual (PVR) was 208.2 mL (21.9% 200–300 mL). IPSS mean was 19.8 and QoL was “mostly dissatisfied.” Following PAE, mean PSA was reduced by 3.2 ng/mL (38.1%, p = 0.3014), the mean prostate volume reduction was 59.2 mL (40.3%, n = 19, p < 0.0001), and the average PVR reduction was 150.3 mL (72.2%, n = 27, p = 0.0002). Average IPSS score was also lower (11.9; 60.1%, n = 25, p < 0.0001) and QoL was reduced to “mostly satisfied” (p < 0.0001). Technical success was 100% with 24% minor morbidities. Conclusion PAE is a successful treatment for patients with BPH resulting in large prostates that are not good candidates for simple prostatectomy, providing optimal care with less operative and postoperative complications.