bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tax enforcement efforts and stock price crash risk: Evidence from China
Authors: Chen Shihua , Ye Yan , Jebran Khalil 
Published: December 2021

AbstractWe propose that firms in regions with strong tax enforcement efforts have low stock price crash risk. Using a large sample of Chinese firms from 2003 to 2017, we find that tax enforcement efforts negatively affect future crash risk. This negative effect is stronger among state‐owned companies but weaker when information opacity is higher for firms. These results are robust to alternative measures, additional controls, and additional analyses. We also show that tax avoidance and accounting conservatism are two potential channels through which tax enforcement efforts affect crash risk. The findings contribute to the literature by elaborating that tax enforcement efforts not only alleviate tax‐avoiding activities but also can act as a governance mechanism in reducing crash risk in an emerging economy context.
Chromatin‐remodeling complexes: Conserved and plant‐specific subunits in Arabidopsis
Authors: Shang Ji‐Yun , He Xin‐Jian 
Published: December 2021

ABSTRACTAdenosine triphosphate‐dependent chromatin remodeling complexes are important for the regulation of transcription, DNA replication, and genome stability in eukaryotes. Although genetic studies have illustrated various biological functions of core and accessory subunits of chromatin‐remodeling complexes in plants, the identification and characterization of chromatin‐remodeling complexes in plants is lagging behind that in yeast and animals. Recent studies determined whether and how the Arabidopsis SWI/SNF, ISWI, INO80, SWR1, and CHD chromatin remodelers function in multi‐subunit complexes in Arabidopsis. Both conserved and plant‐specific subunits of chromatin‐remodeling complexes have been identified and characterized. These findings provide a basis for further studies of the molecular mechanisms by which the chromatin‐remodeling complexes function in plants.
Effect of green tea extract loaded chitosan microparticles on facial skin: A split‐face, double‐blind, randomized placebo‐controlled study
Authors: Wisuitiprot Wudtichai , Ingkaninan Kornkanok , Jones Sirada , Waranuch Neti 
Published: December 2021

AbstractIntroductionThe bioactivities of green tea extract were indicated to promote skin health in vitro. Few clinical studies reported on skin nourishment of topical applying green tea extract due to the limited skin absorption.MethodsThis current study evaluated the clinical effectiveness and safety of green tea extract encapsulated chitosan microparticles (GTP) in emulsion base on a split‐face, double‐blind, randomized placebo‐controlled study. Twenty‐nine female volunteers were recruited into the study. They were randomly assigned to apply GTP and placebo creams on each half face for 8 weeks. The facial skin properties on both sides were monitored and evaluated every 2 weeks.ResultsThe results revealed that skin elasticity (R2) of half face treated with GTP cream (0.748 ± 0.05) was superior to another that received placebo cream (0.722 ± 0.05) at 4th week. In addition, melanin index implying skin dullness of the half face that received GTP cream significantly improved within the 6th week after application (placebo =295.60 ± 58.81, GTP =282.70 ± 59.62). Most importantly, the photographs clearly indicated that the decreasing in facial wrinkles of volunteers applied with GTP cream was more than those applying placebo cream. Signs of skin irritation were not evident in both treatment and placebo cream groups.ConclusionBased on study outcomes, the green tea extract encapsulated chitosan microparticles appear to be the promising active candidate for promoting skin elasticity and improving skin dullness and wrinkles.
The CDC's Division of Adolescent and School Health Approach to Sexual Health Education in Schools: 3 Decades in Review*
Authors: Szucs Leigh E. , Barrios Lisa C. , Young Emily , Robin Leah , Hunt Pete , Jayne Paula E. 
Published: December 2021

ABSTRACTBackgroundSchool health education, including sexual health education, plays a crucial role in shaping adolescents' protective health behaviors, experiences, and outcomes. Adolescents need functional knowledge and skills to practice, adopt, and maintain healthy behaviors for preventing sexually transmitted infections (STIs), including human immunodeficiency virus (HIV), and unintended pregnancy.MethodsThe US Centers for Disease Control and Prevention's Division of Adolescent and School Health (CDC/DASH) has advanced school‐based approaches to STI/HIV and pregnancy prevention through surveillance, research and evaluation, and program partnership and collaboration for over 3 decades.ResultsCDC/DASH uses systematic and innovative strategies to identify the breadth of adolescent sexual health evidence; characterize key elements of effective educational curricula; and provide practical guidance to support school‐based delivery. CDC/DASH's approach to effective health and sexual health education in schools has changed dramatically over the past 30 years and must continue to progress.ConclusionThis paper describes how and why that approach has evolved and outlines directions for the future.
Sensory evaluation of new recipes for Supplemental Nutrition Assistance Program Education (SNAP‐Ed) informs consumer acceptance and recipe development needs
Authors: Ng Melanie K. , Lee Jung Sun , Sanville Laurel M. , Cotta‐Rivera Edda , Dallas Jackie , Pencek Amanda , Powell Ariathni , Williams Breeanna , Moore Carla J. , Cox Ginnefer O. 
Published: December 2021

AbstractFederal nutrition education programs use food demonstrations and tastings of healthy recipes to elicit behavior change among their target audiences, but acceptance and liking of such recipes has not been systematically evaluated. This study aimed to assess acceptability and key sensory attributes (appearance, flavor, texture, saltiness, and sweetness) of culturally tailored recipes using sensory evaluation methods in a nontraditional setting. Affective ballots were used to assess overall liking (OL), key attributes, and preparation intent of seven new recipes on a 9‐point hedonic scale. Open‐ended feedback was also collected. A convenience sample of 338 low‐income adults rated two out of seven recipes as meeting a standard acceptability rating ≥7. These ratings were significantly related to their preparation intent. Flavor and texture were revealed as attributes that significantly influenced OL. Findings support the practicality of sensory evaluation methodology in nontraditional settings for the development of recipes in Federal nutrition education programs.Practical applicationsThis novel application of sensory evaluation in nontraditional settings can provide curriculum developers' of federal nutrition education programs a holistic understanding of their target audience's recipe needs. Developers have the ability to analyze specific attributes, ask about preparation intent behaviors, and more accurately determine areas for improvement of each recipe through these targeted consumer sensory tests. Developers can thus ensure that recipes in their curricula (present and future) are well equipped to promote healthy behavior change. Additionally, this information can be built upon over the course of many sensory evaluations of more recipes to create a living record of the target audience's likes and dislikes for future recipe development. The inclusion of sensory evaluation in Federal nutrition programs provides opportunity for collaboration between sensory scientists and these programs nationwide.
Paediatric ultrasound‐guided vascular access: Experiences and outcomes from an emergency department educational intervention
Authors: Calcutt Trent , Brady Robyn , Liew Kong 
Published: December 2021

AimThis quality assurance project aims to describe the provision of an ultrasound‐guided vascular access education package to paediatric emergency department staff. It subsequently aims to measure clinician and departmental responses to this educational intervention to support future effective education provision.MethodsParticipants were opt‐in emergency department staff. Staff were required to be approved to insert intravenous cannulae in the department. A minimum of 50% were non‐rotational staff. The educational package consisted of a theory phase (pre‐learning video, information document), a practical phase (intensive 90–120 minute individualised session using a mix of live subjects/training equipment), and an embedding phase (education group available for procedural supervision). Data collection was via de‐identified, encoded self‐reported survey data and logbooks.ResultsTwenty‐three staff were enrolled for training. Sixteen (69.9%) were non‐rotational. Prior to the education intervention, 18 trainees (78.3%) had placed no successful ultrasound‐guided peripherally inserted venous cannulae. By 15 weeks following training, six participants (28.6%) had achieved a predetermined competency benchmark; 61.9% had placed at least one successful ultrasound‐guided cannula. Difficult intravenous (IV) access predictors were present in 46.3% of patients throughout the data collection period, with infants overrepresented in this group (64.9% with difficult IV access predictors). IV access attempts by staff with prior ultrasound experience increased from 11.0 to 81.8% post‐education intervention.ConclusionsA low‐resource brief educational intervention around ultrasound‐guided vascular access is achievable. Several barriers to education uptake were presented. Targeting the group of trainees with a high degree of motivation led to the highest yield of benchmark competency acquisition.
Surviving versus thriving: The wellbeing of primary school aged children in Tonga
Authors: Langridge Fiona C , 'Ofanoa Malakai , Fakakovikaetau Toakase , Wilkinson‐Meyers Laura , Percival Teuila , Riley Anne W , Grant Cameron C 
Published: December 2021

AimTo enable improvements in global child health, the focus must move beyond child survival to child wellbeing. In the Pacific Islands, the wellbeing of children has received little attention. This study aimed to investigate the wellbeing of children from three primary schools in Tonga.MethodsA cross‐sectional survey was completed in three primary schools in Nuku'alofa with children aged 5–15 years. The study participants (256 children, 143 caregivers) completed the Child Health and Illness Profile – Child Edition, CHIP‐CE (Version 1.0).ResultsOn average, >70% of children and caregivers described home and school environments as positive. From the children's reports, boys had significantly lower scores for risk avoidance than girls (3.40 vs. 3.73, P < 0.001). Children aged 5–7 versus 8–15 years had significantly lower scores for satisfaction (3.63 vs. 3.92, P = 0.002), resilience (3.34 vs. 3.56, P = 0.016) and achievement (3.25 vs. 3.62, P = 0.002). From the caregivers' report, girls had significantly lower scores for academic performance than boys (3.60 vs. 3.81, P = 0.04). Boys had significantly lower scores for individual risk association compared to girls (3.93 vs. 4.29, P = 0.01). Overall CHIP‐CE scores were lower than those of comparable populations in the West, while at the same time protective factors were documented.ConclusionsUnderstanding child wellbeing in the Pacific is critical for strengthening protective factors known to mitigate poor child health outcomes. Continuing to base global child health success on child survival alone misses opportunities for improving the wellbeing of nations.
Clinical and demographic features of minor salivary gland tumors: A collaborative study of 480 cases
Authors: Bruzinga Fábio Fernandes Borém , Fernandes Fernanda Carvalho Fulgêncio , Dias Fernanda Ribeiro , Lima Marla Gabriela , de Souza Paulo Eduardo Alencar , de Aguiar Maria Cássia Ferreira , Grossmann Soraya de Mattos Camargo 
Published: December 2021

AbstractObjectiveTo describe the frequency, clinical, and demographic features of minor salivary gland tumors and possible associated factors.Materials and methodsA cross‐sectional study was conducted. Clinical and demographic data were collected from biopsy records of two oral pathology services. Chi‐square test, Fisher's exact test, and descriptive statistical analysis were performed.ResultsA total of 480 (0.89%) minor salivary gland tumors were retrieved, 272 (56.7%) benign and 147 (30.7%) malignant. Sixty‐one (12.6%) had no subtype specification. Most patients were women (307/64.0%), in sixth decade of life (80/16.7%), with a mean age of 45.32 years. Palate was the most common site (336/70.1%). Pleomorphic adenoma (PA; 245/51.1%), mucoepidermoid carcinoma (MEC; 70/14.6%), and adenoid cystic carcinoma (ACC; 43/8.9%) were the most frequent tumors. Symptomatic case, recurrence, and tobacco use were associated with malignancy (p < 0.05). PA and MEC were more frequent in palate (p < 0.05). No association between the three most frequent histological types and gender or age group was observed (p > 0.05).ConclusionsThis represents one of the largest exclusive series of minor salivary gland tumors in Brazil and worldwide. PA, MEC, and ACC were the most frequent tumors. Clinical and demographic data are similar from Brazilian studies or from other countries.
Recovery characteristics and parental satisfaction in pediatric procedural sedation
Authors: Cortellazzo Wiel Luisa , Monasta Lorenzo , Pascolo Paola , Servidio Alessia Giuseppina , Levantino Laura , Fasoli Silvia , Saccari Alessia , Cozzi Giorgio , Barbi Egidio 
Published: December 2021

AbstractBackgroundDespite being a standard of care for children undergoing stressful procedures, little data exist on parental perception of pediatric sedation.AimsThis study aimed to investigate recovery characteristics and parental satisfaction for pediatric sedations performed with four widely used sedative regimens.MethodsA prospective observational study was conducted at the Institute for Maternal and Child Health of Trieste, Italy, enrolling children undergoing procedural sedation with one of the following pharmacological regimens: propofol, propofol + midazolam, ketamine + propofol, and dexmedetomidine + midazolam. A questionnaire was used to assess the occurrence of symptoms upon recovery from sedation and the following day, and the caregivers' satisfaction for both the recovery pattern and the overall sedation experience, according to a numerical rating scale (0–10). Answers were collected through a telephone survey. The primary outcome was the difference in the quality of the recovery as perceived by caregivers; the secondary and tertiary outcomes were the perceived quality of the overall sedation experience and the frequency of sedation‐related adverse events, respectively.ResultsData from 655 patients, 149 receiving propofol, 245 propofol + midazolam, 134 ketamine + propofol, and 127 dexmedetomidine + midazolam, were analyzed. The level of parents' satisfaction for both the recovery and the sedation experience was overall high and increased with the patients' age in all the pharmacological groups (Spearman's rank correlation, ρ .083, p = .033, and ρ .087, p = .026, respectively), with no statistically significant differences between groups when adjusting for age. The occurrence of irritability, prolonged sleepiness, hyperactivity, unsteadiness, hallucinations, emesis, and respiratory distress at any moment negatively affected parental satisfaction.ConclusionsIn this study, caregivers' satisfaction with pediatric sedation was high, regardless of the regimen used. Lower parental satisfaction was associated with younger age, irritability after sedation, prolonged sleepiness, hyperactivity, unsteadiness, hallucinations, emesis, and respiratory distress.
A review of the diagnosis and management of pediatric psychodermatologic conditions: Part II
Authors: Mosca Megan , Martin Kari , Hong Julie , Hadeler Edward , Brownstone Nicholas , Koo John 
Published: December 2021

AbstractPediatric psychodermatologic conditions encompass both primary dermatologic conditions with psychiatric comorbidities and primary psychiatric conditions with self‐induced dermatologic manifestations. Detection, diagnosis, and management of primary psychiatric conditions with dermatologic manifestations are challenging due to patient‐perceived stigma and lack of educational opportunities for dermatology providers. This two‐part series highlights the most up‐to‐date evidence‐based data and management techniques of some of the more common dermatoses of primary psychiatric conditions in children. Part I includes trichotillomania, skin picking disorder, and onychophagia, and part II covers dermatitis artefacta, body dysmorphic disorder, and delusions of parasitosis by proxy, with special considerations for family dynamics.
KRIT1‐positive hyperkeratotic cutaneous capillary venous malformation
Authors: Matarneh Bayan , Cottrell Catherine E. , Choi Samantha , Pearson Gregory , Fung Bonita , Koo Selene C. , Lillis Anna P. , Ho Mai‐Lan , Fernandez Faith Esteban 
Published: December 2021

AbstractCerebral cavernous malformations (CCM) may present in sporadic or familial forms, with different cutaneous manifestations including deep blue nodules, capillary malformations, and hyperkeratotic cutaneous capillary venous malformations (HCCVM). We report the case of an infant with a KRIT1‐positive HCCVM associated with familial CCM. Moreover, histopathology showed positive immunohistochemical stain with GLUT1, further expanding the differential diagnosis of GLUT1‐positive vascular anomalies.
The involvement of host circadian clocks in the regulation of the immune response to parasitic infections in mammals
Authors: Carvalho Cabral Priscilla , Tekade Kimaya , Stegeman Sophia K. , Olivier Martin , Cermakian Nicolas 
Published: December 2021

AbstractCircadian rhythms are recurring variations of physiology with a period of ~24 h, generated by circadian clocks located throughout the body. Studies have shown a circadian regulation of many aspects of immunity. Immune cells have intrinsic clock mechanisms, and innate and adaptive immune responses – such as leukocyte migration, magnitude of inflammation, cytokine production and cell differentiation – are under circadian control. This circadian regulation has consequences for infections including parasitic infections. In the context of Leishmania infection, the circadian clock within host immune cells modulates the magnitude of the infection and the inflammatory response triggered by the parasite. As for malaria, rhythms within the immune system were shown to impact the developmental cycles of Plasmodium parasites within red blood cells. Further, host circadian rhythms impact infections by multicellular parasites; for example, infection with helminth Trichuris muris shows different kinetics of worm expulsion depending on time of day of infection, a variation that depends on the dendritic cell clock. Although the research on the circadian control of immunity in the context of parasitic infections is in its infancy, the research reviewed here suggests a crucial involvement of host circadian rhythms in immunity on the development and progression of parasitic infections.
Asbestos‐induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species
Authors: Okazaki Yasumasa 
Published: December 2021

AbstractAsbestos fibers have been used as an industrial and construction material worldwide due to their high durability and low production cost. Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos‐induced malignant mesothelioma (MM) remains. According to epidemiological data, the onset of MM is estimated to occur after a latent period of 30–40 years from initial exposure to asbestos fibers; thus, the continuous increase in MM is a concern. To explore the molecular mechanisms of MM using animal models, iron saccharate with iron chelator‐induced sarcomatoid mesothelioma (SM) revealed hallmarks of homozygous deletion of Cdkn2a/2b by aCGH and microRNA‐199/214 by expression microarray. Oral treatment of iron chelation by deferasirox decreased the rate of high‐grade SM. Moreover, phlebotomy delayed MM development in crocidolite‐induced MM in rats. In Divalent metal transporter 1 (Dmt1) transgenic mice, MM development was delayed because of low reactive oxygen species (ROS) production. These results indicate the importance of iron and ROS in mesothelial carcinogenesis. The aims of this review focus on the pathogenesis of elongated mineral particles (EMPs), including asbestos fibers and multiwalled carbon nanotubes (MWCNTs) that share similar rod‐like shapes in addition to the molecular mechanisms of MM development.
Maternal early‐pregnancy ferritin and offspring neurodevelopment: A prospective cohort study from gestation to school age
Authors: Sammallahti Sara , Tiemeier Henning , Reiss Irwin K. M. , Muckenthaler Martina U. , El Marroun Hanan , Vermeulen Marijn 
Published: December 2021

AbstractBackgroundIron plays a role in many key processes in the developing brain. During pregnancy, iron supplementation is widely recommended to prevent and treat iron deficiency; however, the prevalence of iron deficiency and the risk of iron overload vary greatly between populations. Evidence on the role of high levels of maternal ferritin, a storage iron marker during pregnancy in relation to offspring neurodevelopment is lacking.ObjectiveOur main objective was to examine if maternal ferritin levels during pregnancy are associated with child cognitive and motor abilities.MethodsWe included Dutch mother‐child dyads from the prospective population‐based Generation R Study, born in 2002–2006. We compared children whose mothers had high (standard deviation score >+1) or low (standard deviation score <−1) early‐pregnancy ferritin to children whose mothers had intermediate ferritin (reference group) using linear regression. Children underwent non‐verbal intelligence and language tests at 4–9 years (cognitive abilities), finger‐tapping and balancing tests at 8–12 years (motor abilities), and structural magnetic resonance imaging at 8–12 years (brain morphology). Covariates were child age, sex, maternal intelligence quotient estimate, age, body‐mass‐index, education, parity, smoking and alcohol use.ResultsOf the 2479 mother‐child dyads with data on maternal ferritin and at least one child neurodevelopmental outcome, 387 mothers had low (mean = 20.6 µg/L), 1700 intermediate (mean = 64.6 µg/L) and 392 high (mean = 170.3 µg/L) early‐pregnancy ferritin. High maternal ferritin was associated with 2.54 points (95% confidence interval ‐4.16, ‐0.92) lower child intelligence quotient and 16.02 cm3(95% confidence interval ‐30.57, ‐1.48) smaller brain volume. Results remained similar after excluding mothers with high C‐reactive protein. Low maternal ferritin was not associated with child cognitive abilities. Maternal ferritin was unrelated to child motor outcomes.ConclusionHigh maternal ferritin during pregnancy was associated with poorer child cognitive abilities and smaller brain volume. Maternal iron status during pregnancy may be associated with offspring neurodevelopment.