bluuebunny/crossref_metadata_2025_split huggingface dataset:
Czy Szekspira da się „przerobić” na kryminał? O niektórych nowych, „uwspółcześniających” filmowych adaptacjach dzieł wielkiego dramaturga
Authors: Kajtoch Wojciech 
Published: October 2021

The paper discusses selected screen adaptations of Shakespeare’s plays: Hamlet (dir. M. Almereyda, 2000), Coriolanus (dir. R. Fiennes 2011), Macbeth (dir. G. Wright, 2006), Cymbeline (dir. M. Almereyda, 2014), Macbeth (an episode of the BBC series Shakespeare Re-Told, 2005) as well as episodes 3 and 4 from Yevhenіy Zviezdakov’s series Diekoracyi ubijstwa (2015). The common feature of these screen adaptations is moving the plot to modern times and emphasising those elements which resemble typical components of crime dramas. The paper points to the difficulties the directors had to overcome to make such “upgrading” makeovers viable.
O kilku związkach Chrisa Markera z kulturą popularną
Authors: Kita Barbara 
Published: October 2021

In the French avant-garde artist’s and new technology experimentalist’s rich output, one may find interesting references to popular culture, though the latter is not usually commensurate with niche, experimental works. Marker was not always an active author of such pop cultural experiences but even his famous photo-novel created in the 1960s — Jetty was adapted into a science-fiction film 12 Monkeys (1995) by Terry Gilliam. Moreover, Marker — an artist constantly searching for new forms of expression — was often inspired by technical novelties and new media were used in his works — evolving from documentaries-essays, through experimental short videos (Zapping Zone, 1985–1994) to an interactive CD Rom, Immemory (1997), which attracted new audiences. Being fascinated with technological possibilities, Marker effectively made use of new technologies while adapting a video game (Level 5, 1996) or entering virtual reality (Guillaume’s blog from Egypt, starting from 2007) and, at the same time, entering the sphere of pop-cultural practices.
W stronę megalomanii narodowej na kanwie tetralogii Jacka Komudy pod tytułem „Samozwaniec” (glosa i kilka uwag na marginesach powieści)
Authors: Sztyber Radosław 
Published: October 2021

The sketch is an attempt to analyse chosen details noticed in Jacek Komuda’s novel cycle entitled Orły na Kremlu [Eagles at the Moscow Kremlin]. The discussed matters concern particularly two fragments of dialogues enriched with clear allusions to Wojciech Dembołęcki’s quite widely known treatise Wywód jedynowłasnego państwa świata [Treatise on the only country in the world] and an endnote — delivered by the author himself — on the aforementioned book (published in 1633) with additions: some brief characteristics of Dembołęcki and his output. As it appears, any observation or reference to the works of the Polish monk (who died in the mid-seventeenth century) is not extracted from archives, old prints, as Komuda assures us (describing his course of work in his interviews). They rather come both from articles or excerpts found in research books released by scholars. Besides, Komuda in his declared approach to literary work does intend to differentiate significantly from Henryk Sienkiewicz’s masterpiece (Trylogia [The Trilogy]), however many writings of Komuda deny such an idea, which has been proven thorough studies. Nevertheless, the Wywód’s quotations and its transparent paraphrases seem to be valuable in contemporary historical prose, for thanks to them the reader may be acquainted with peopleʼs (especially Polish noblemenʼs) mentality at the beginning of the seventeenth century. Unfortunately, the notes bring some meaningful misunderstandings revealing Komuda’s ignorance, because one may fail in correctly recognising the textʼs main message (Przewagi elearów polskich [The exploits of elears]) or the origin of rhymes cited by the novelist. The sketch closes with a few thoughts concentrated on a possible Samozwaniec qualification within Adam Mazurkiewicz’s typology proposal of historical prose published nowadays.
Impact of macroeconomic factors on inflation: An assessment on indian economy by using vector auto-regressive modeling
Authors: Das Mihir , Pachetas Gopi Krishna 
Published: October 2021

Inflation is the sustained rise in the prices of commodities. Central Banks have the critical responsibility of ensuring price stability; however, every attempt should be made to ensure that price stability should not hit economic growth. Thus, it becomes imperative for Central Banks to determine the key fiscal and monetary factors that have the greatest impact on domestic price levels. Based on these factors, it can tackle the problem of inflation effectively and efficiently. Further, there are several global price indices and factors that need to be factored in while tackling the problem of inflation. The objective of the current study is to empirically determine the macroeconomic factors that play a significant role in influencing inflation in India. The study considers international food and oil price indices amongst other macroeconomic variables such as the fiscal deficit, index of industrial production, exchange rate, MIBOR, and money supply in order to explain inflation. Monthly data for each of the above variables were collected for the research period 2000-10. The study is based on Vector Auto-Regressive modeling. The Augmented Dickey-Fuller Unit Root Test was performed to test for stationarity of all of the time-series data. The results of the Granger causality tests indicate that fiscal indicators such as fiscal deficit and international factors such as international food and oil price indices play a significant role in influencing inflation. The research outcomes conform to the results of several earlier studies.
IMPROVING BIO-OIL QUALITY VIA CO-PYROLYSIS EMPTY FRUIT BUNCHES AND POLYPROPILEN PLASTIC WASTE
Authors: Sunarno Sunarno , Randi Alfi , Utama Panca Setia , Yenti Silvia Reni , Wisrayetti Wisrayetti , Wicakso Doni Rahmat 
Published: October 2021

The current consumption of fuel oil, especially gasoline and diesel oil, is increasing. Along with the decline in production, national oil production activities encourage efforts to find alternative fuels as a substitute for oil-based energy supplies. Bio-oil is an environmentally friendly alternative fuel for diesel that can be used as fuel. In this study, the raw materials were palm oil empty bunches and polypropylene plastic waste. The purpose of this study was to determine the effect of the ratio of raw material for oil palm empty fruit bunches and polypropylene, the effect of co-pyrolysis temperature on the yield of bio-oil and determine the characteristics of the resulting bio-oil. This study used the variable ratio of oil palm empty fruit bunches and polypropylene (100:0, 80:20, 70:30 and 60:40) and co-pyrolysis temperature (400, 450, 500 and 550 °C). The results showed that the highest yield of bio-oil was obtained, namely 41.6% with a ratio of EFB: PP (80:20) at temperature of 450 °C. The characterization of the product obtained was density of 0.891 g/ml, viscosity of 4.18 cSt, pH of 3.38 and calorific value of 43.2 MJ/kg.
Impulsively-Laser Excitation and Propagation of Ultrasonic Waves through Nanomagnetic Fluid
Authors: Baev A. R. , Мitkovets A. I. , Asadchaya M. V. , Mayorov A. L. 
Published: October 2021

Magnetic fluids belong to the class of nanomaterials with a high gain of light absorption, aggregative and sedimentation stability as well as controllability by external fields, which is of interest to use in the field of optoacoustics. The purpose of the work was to experimentally study the effect of the optoacoustic transformation in a magnetic fluid, depending on the concentration of magnetic colloidal particles, boundary conditions, intensity of the laser as well as to identify the possibilities of using the magnetic fluid as an element of the optoacoustic transformation in a number of applications.A brief analysis of the optoacoustic transformation mechanism in a magnetic fluid was carried out and a technique and an installation that implements the shadow measurement variant developed. A Lotis type laser was used as a source of ultrasonic pulse-laser excitation in magnetic fluids. A quartz and air were used as a material transmitting the energy of laser radiation in a magnetic fluid. Receiving of ultrasound signals was made by a piezoelectric probe at a working frequency of 5 MHz. In the measurement process, the concentration of the dispersed phase in tmagnetic fluid was varied from zero to 8 % and the energy in the impulse–from zero to 10 mJ.For the first time, it was established that: a) an amplitude of the function of the optoacoustic transformation in a magnetic fluid, depending on the concentration of the dispersed phase, has a maximum determined by the fluid physical properties and boundary conditions; b) for all samples within the measurement error, a quasilinear dependence of the specified amplitude of energy in the laser pulse in the range of 0–8 MJ has been established.A number ways of the optoacoustic effects in magnetic fluids to use in ultrasonic testing, measuring the intensity of the laser radiation had been suggested.
Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus
Authors: Li Chun , Feng Cong , Ma Guangyuan , Fu Shaoyin , Chen Ming , Zhang Wenguang , Li Jinquan 
Published: October 2021

Abstract
Background

Cashmere goat is famous for its high-quality fibers. The growth of cashmere in secondary hair follicles exhibits a seasonal pattern arising from circannual changes in the natural photoperiod. Although several studies have compared and analyzed the differences in gene expression between different cashmere growth stages, the selection of samples in these studies relies on research experience or morphological evidence. Distinguishing cashmere growth cycle according to gene expression patterns may help to explore the regulation mechanisms related to cashmere growth and the effect of melatonin from a molecular level more accurately.
Results

In this study, we applied RNA-sequencing to the hair follicles of three normal and three melatonin-treated Inner Mongolian cashmere goats sampled every month during a whole cashmere growth cycle. A total of 3559 and 988 genes were subjected as seasonal changing genes (SCGs) in the control and treated groups, respectively. The SCGs in the normal group are divided into three clusters, and their specific expression patterns help to group the cashmere growth cycle into anagen, catagen and telogen stages. Some canonical pathways such as Wnt, TGF-beta and Hippo signaling pathways are detected as promoting the cashmere growth, while Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction, Jak-STAT, Fc epsilon RI, NOD-like receptor, Rap1, PI3K-Akt, cAMP, NF-kappa B and many immune-related pathways are detected in the catagen and telogen stages. The PI3K-Akt signaling, ECM-receptor interaction and Focal adhesion are found in the transition stage between telogen to anagen, which may serve as candidate biomarkers for telogen-anagen regeneration. Pairwise comparisons between the control and melatonin-treated groups also indicate 941 monthly differentially expressed genes (monthly DEGs). These monthly DEGs are mainly distributed from April and September, which reveal a potential signal pathway map regulating the anagen stage triggered by melatonin. Enrichment analysis shows that Wnt, Hedgehog, ECM, Chemokines and NF-kappa B signaling pathways may be involved in the regulation of non-quiescence and secondary shedding under the influence of melatonin.
Conclusions

Our study decodes the key regulators of the whole cashmere growth cycle, laying the foundation for the control of cashmere growth and improvement of cashmere yield.
Ground Motion Parameters For the 2015 Nepal Earthquake
Authors: Basu Jahnabi , Podili Bhargavi , Raghukanth S. T. G. , Srinag D 
Published: October 2021

Abstract
The 25th April 2015 Nepal earthquake is the first major event in the Himalayan orogeny that provides a relatively well recorded dataset. This paper presents a comprehensive analysis of the mainshock and its five major aftershocks through 21 well established ground motion parameters. The analysis is presented for near field stations of the Kathmandu basin and far field stations of the Indo-Ganga basin, including the site response behavior with varying sediment thickness. In addition, a new ground motion model is derived for all the 21 parameters using moment magnitude, rupture distance, site class and sediment depth as predictor variables.
Persulfate Activation by Ferrocene-based Metal-organic Framework Microspheres for Efficient Oxidation of Organic Pollutants
Authors: Lv Xiaoyu , Leng Yanqiu , Wang Rongyao , Wei Yan , Ren Xiaohua , Guo Weilin 
Published: October 2021

Abstract
Ferrocene-based metal-organic framework with different transition metals (M-Fc-MOFs, M=Fe, Mn, Co) were synthesized by a simple hydrothermal method and used as a heterogeneous catalyst for persulfate activation. The samples were characterized by X-ray diffraction, transmission electron microscopy, X-ray electron spectroscopy, cyclic voltammetry and electrochemical impedance spectroscopy. Meanwhile, the influences of factors such as catalyst dosage, persulfate concentration and pH on the degradation of acid orange 7 (AO7) were studied in detail. The results showed that hollow cobalt-based ferrocenyl metal-organic framework microspheres (Co-Fc-MOFs) exhibited the best catalytic performance, which is closely related to the synergy of Fc/Fc+ and Co2+/Co3+ cycles in persulfate activation. Free radical quenching studies indicated that both sulfate and hydroxyl appeared to contribute to the degradation of AO7.
Circulating Tumor Cell Methylation Profiles Reveal the Classification and Evolution of Non-small Cell Lung Cancer
Authors: Jiang Jia-Hao , Chen Chang-Yue , Gao Jian , Li Jing , Lu Yuan , Fang Wang , Wang Hai-Kun , Yuan Yun-Feng , Ding Jian-Yong 
Published: October 2021

Abstract
Backgrounds: The ability of circulating tumor cells (CTCs) to identify lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) holds great promise for improving pathological diagnosis and selecting treatment in non-small cell lung cancer (NSCLC). In addition, previous studies have shown that DNA methylation exhibits cell and tissue specificity. Thus, we aimed to explore the methylation status of CTCs in LUAD and LUSC and identify the potential biomarkers. Methods: we first analyzed Infinium 450K methylation profiles obtained from The Cancer Genome Atlas and Gene Expression Omnibus and further identified the results by performing whole-genome sequencing of CTCs in tumor and matched normal lung tissues and white blood cells from 6 NSCLC patients. Results: the bioinformatic analysis revealed that an NSCLC-specific DNA methylation marker panel which could accurately distinguish between LUAD and LUSC with high diagnostic accuracy. The whole-genome sequencing of CTCs in NSCLC patients also showed 100% accuracy for distinguishing between LUAD and LUSC based on CTC methylation profiles. To investigate the function of CTCs, we further analyzed similar and different methylation profiles between CTCs and their primary tumors and found very high similarities between CTCs and their primary tumor tissues, indicating that these cells inherit information from primary tumors. CTCs also showed some characteristics that were different from those of the primary tumor tissues, suggesting that CTCs evolve some unique characteristics after migrating from the primary tumor; these characteristics may be one of the reasons for the ability of tumor cells to evade immune surveillance.Conclusion: thus, our study provides insight into the potential use of CTCs in pathological classification of NSCLC patients as well as CTC primary tumor inheritance and CTC evolution influence metastasis and immune escape.
Dynamics of a degenerately damped stochastic Lorenz-Stenflo system
Authors: Zhou Liangke , Zeng Caibin 
Published: October 2021

Abstract
Little seems to be known about the sensitivity of steady states for stochastic systems. This paper discusses such dynamics of a degenerately damped stochastic Lorenz-Stenflo model. Precisely, the solution is proved to be a nice diffusion via the Lie bracket technique and non-trivial Lyapunov functions. The finiteness of the expected positive recurrence time entails the existence problem. On the other hand, a cut-off function is constructed to show the non-existence result via proof by contradiction. For other interesting cases, the expected recurrence time is shown to be infinite.
ISG20L2 as a Novel Prognostic Biomarker Facilitates the Progression of Pancreatic Cancer Via Glycolysis
Authors: Wei Jianming , Gao Xibo , Ren Bingbing , Sun Daqing , Liu Tong 
Published: October 2021

Abstract
Background: Longstanding type 2 diabetes mellitus (T2DM) is an increased risk of pancreatic cancer (PC) in western populations, and PC is also a cause of T2DM. However, the association of glucose metabolism between T2DM and PC remains unclear. Methods: Differentially expressed genes (DEGs) were identified by bioinformatic analysis from Gene Expression Omnibus (GEO) datasets GSE20966 and GSE16515, respectively. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Gene Set Enrichment Analysis (GSEA), the Kaplan-Meier (KM) Plotter and Tumor Immune Estimation Resource (TIMER) database were applied. Pancreatic cancer cell lines and primary PDAC samples were used. Cell culture, immunohistochemistry (IHC), siRNA transfection, Western blot, RT-PCR, and migration assay, animal xenograft model studies and statistical analysis were performed in this study. Results: We identified 64 DEGs in GSE20966 of T2DM, and 296 DEGs were identified in GSE16515 of pancreatic cancer, respectively. T2DM-DEGs were mainly enriched in synaptic vesicle cycle, protein export. KEGG pathways in pancreatic cancer included spliceosome, RNA transport. Here, ISG20L2 was identified as only a co-expressed gene between T2DM and PDAC. We found that the expression of ISG20L2 was associated with tumor immune cell infiltration. ISG20L2 was significantly upregulated in PDAC and associated with prognosis of PDAC patients. Moreover, ISG20L2 expression was regulated by GLUT1 , HK2 , LDHA , PKM1 and PKM2 related with glycolysis in PDAC. ISG20L2 promoted PDAC cell proliferation and migration both in vitro and in vivo. Conclusion: This study showed that ISG20L2 promoted the progression and ISG20L2 may be a potential therapeutic strategy in PDAC.
Synthesize Analysis of the IFN-γ and Immune Infiltrates of m6A RNA Methylation Regulators in Human Skin Cutaneous Melanoma
Authors: Wang Yuqi , Huang Le , Li Mingxin , Qi Yunfeng 
Published: October 2021

Abstract
Background: SKCM is a major common cancer with highly mortality and morbidity, causing about 72% of deaths in skin carcinoma. In recent years, more scholars have selected one or two m6A regulatory factors to explore the abnormal expression and potential mechanism of m6A in tumorigenesis and development. So as to find the relevant biomarkers in the whole tumorigenesis process.Methods: In current study, we used public transcriptome datasets from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Genotype-Tissue Expression (GTEx) to investigate the relationships between N6-methyl adenosine(m6A) regulators genes and Skin cutaneous melanoma (SKCM). Then, SKCM patients were grouped based on the cluster analysis of m6A regulators expression. Compared the relationship between Interferon (IFN)-γ and immune infiltrates. Results: Based on the survival curves of subgroups, we selected 20 potential predictive m6A-related genes were overexpressed in SKCM. And based on the typing results, we got the 15 differential expression genes between the three groups. Four of them (CYP2U1, SEMA6A, GRIA2, and TSPAN13) were selected in Cox regression, which were significant expression in overall survival(p<0.05). Interferon (IFN)-γ is a central cytokine, which effecting immune-provoking and recognizing transformed cells in anti-tumour immunity. Conclusions: To investigate the correlation between IFN-γ and SKCM. We have identified that IFN-γ is a potential factor for cancer therapy, and affecting expression pathways of SKCM. Among them, IFN-γ and WTAP were the most positive correlation. These sights suggest that IFN-γ can potentially be utilized for immune pathway such as melanoma skin cancer.
Incorporation of potent and selective cytochrome P450 1B1 inhibitors into Ru(II) scaffolds provides unprecedented control over enzyme activity with light
Authors: Havrylyuk Dmytro , Hachey Austin , Fenton Alexander , Heidary David , Glazer Edith 
Published: October 2021

Abstract
The cytochrome P450 family of enzymes (CYPs) are important targets for medicinal chemistry. Recently, CYP1B1 has emerged as a key player in chemotherapy resistance in the treatment of cancer. This enzyme is overexpressed in a variety of tumors, and is correlated with poor treatment outcomes; thus, it is desirable to develop CYP1B1 inhibitors to restore chemotherapy efficacy. However, possible off-target effects, such as inhibition of liver CYPs responsible for first pass metabolism, make selective inhibition a high priority to avoid possible drug-drug interactions and toxicity. Here we describe the creation of light-triggered CYP1B1 inhibitors as “prodrugs”, and achieve >6,000-fold improvement in potency upon activation with low energy (660 nm) light. The novel systems provide a selectivity index of 4,000–100,000 over other off-target CYPs. One key to the design was the development of novel, coordinating CYP1B1 inhibitors which suppress enzyme activity at pM concentrations in live cells. The coordinating group enforces inhibitor orientation in the active site by anchoring to the iron. The second essential component was the biologically compatible Ru(II) scaffold that cages the inhibitors before photochemical release. These Ru(II) photocages are anticipated to provide similar selectivity and control for any coordinating CYP inhibitors.