bluuebunny/crossref_metadata_2025_split huggingface dataset:
DORA AND HER SISTERS: FEMALE TROUBLEMAKERS AND THE CULTURAL POLITICS OF DETACHMENT1
Authors: KOLKENBROCK MARIE 
Published: February 2021

AbstractThe cultural history of the ‘troublemaker’ (Dieter Thomä) seems to be dominated by male figures. Critically reflecting on this androcentric focus, the article examines the concept of ‘primary rejection’ as a specific form of ‘troublemaking’ through a re‐reading of Sigmund Freud's ‘Dora Case’. Dora's refusal to continue her treatment in Freud's psychoanalytic setting is not yet informed by a critical discourse against patriarchal normativity, but it has created a moment of irritation that leaves her case open to critical interpretation and retrospective framing. Drawing upon Sara Ahmed's analysis of the ‘cultural politics of emotions’ as well as on Judith Butler's concept of ‘passionate attachment’, this reading of Freud's case study reveals Dora's primary rejection as a gesture of detachment from normative, culturally constructed assignments of identity and desire. The troubling effect of this moment is not only evidenced in the rich body of feminist criticism within the psychoanalytic field and beyond that the Dora Case has produced, but is also mirrored in the primary rejections of female troublemakers in the fictional literature and culture of the twentieth century.
Impact of globalization and governance determinants on economic growth: An empirical analysis of Asian economies
Authors: Xu Xiaodong , Abbas Hafiz Syed Mohsin , Sun Chunxia , Gillani Samreen , Ullah Atta , Raza Muhammad Ahsan Ali 
Published: February 2021

AbstractGlobalization is an inevitable and irresistible process because many regional integrations emerged in the modern era. A global integration analysis, employing a country’s governance practices, offers various economic benefits and exerts socio‐economic pressures on different economies. This study uses the KOF Globalization Index and Institutional Governance Indicators as explanatory variables and examines their impacts on GDP growth as a dependent variable. The study employed Two‐step System GMM with a sample of 45 Asian economies, with the time horizon from 2003 to 2017. The outcomes show that globalization has positively impacted economic growth, sound regulatory control, and political stability. It further states that practical, feasible, and corruption‐free or transparent economic policies significantly contribute to the economic progression of Asian economies, and help to achieve sustainable development. The study concludes by suggesting that some economic and governance recommendations strengthen struggling Asian economies by addressing the globalization phenomenon tactfully. Future studies can be explored by globalization’s impact on socio‐economic development by taking regional integration as a moderating effect, which controls factors such as governance and institutional quality.Practitioners points

The outcomes show that sound regulatory control, political stability, and global integration have positively impacted economic growth.

Corruption‐free or transparent economic policies significantly contribute to the economic progression of Asian economies and help to achieve sustainable development.

Prudent economic governance practices strengthen struggling Asian economies by approaching the globalization phenomenon prudently.
Death determination, organ donation and the importance of the Dead Donor Rule following withdrawal of life‐sustaining treatment: a survey of community opinions
Authors: O'Leary Michael J. , Skowronski George , Critchley Christine , O'Reilly Lisa , Forlini Cynthia , Sheahan Linda , Stewart Cameron , Kerridge Ian 
Published: February 2021

AbstractBackgroundBackground: Organ donation (OD) following circulatory determination of death (DCDD) is an increasing source of transplant organs but little is known about community opinions on treatment withdrawal, determination of death and acceptance of OD in DCDD.AimsTo determine attitudes on death determination in DCDD, the importance of patient choice in treatment withdrawal and OD agreement, and the importance of the ‘Dead Donor Rule’.MethodsScenario‐based online survey of 1017 members of the Australian general public. Mean levels of agreement across respondent's responses to statements were compared by repeated measures ANOVA.Results54% (548) of respondents agreed that a DCDD scenario patient could be declared dead 2 minutes after circulatory standstill, however over 80% nonetheless agreed OD would be appropriate, including 77% (136/176) of those disagreeing with a 2‐minute death declaration. 48% (484) supported OD even if it caused the patient's death. 75% (766) would accept relatively benign ante‐mortem treatments administered to improve transplant outcomes. Over 70% supported a high quadriplegic patient's request to be allowed to die, with 61% (622) agreeing that he should be allowed to donate his organs under anaesthesia, but 60% (610) also agreed that he should first be declared dead.ConclusionsWe found high levels of support for treatment withdrawal in severe brain injury and when requested by a quadriplegic patient. While there was variable agreement with the timing of death determination and with OD under anaesthesia, support for OD was high in both scenarios. For many people death determination prior to OD may not be of paramount importance.
Local Traditions and Global Inspiration: Design Students in Singapore and Norway
Authors: Rynning Margaret 
Published: February 2021

AbstractToday’s graphic design students embody inspiration from sources associated with globalisation, not least online, as well as local impulses from everyday life. In this article, we draw upon the work of two student groups – one in Norway, one in Singapore – to investigate the relationship between input and how they are used to design the packaging of food products. Two classes got similar design briefs and worked simultaneously in two countries, communicating through a common Facebook group. By the end of the project, each class discussed and analysed their sources of inspiration. The design solutions were dissected in separate design elements to look for national characteristics, despite similar international digital inspiration. By investigating cultural differences and similarities in designing based on the hypothesis that design students in Singapore and Norway have the same online design inspiration, this article demonstrates how international sources of inspiration affect the local visual traditions of designers. However, the prioritisation of design elements reveals that despite living in a global network society, designers still adhere to national design traditions.
Process evaluation of couple‐based psychoeducation program for first‐time parents
Authors: Lam Winsome , Ngai Fei Wan 
Published: February 2021

AbstractRationalePostpartum depression is a worldwide public health issue that can have long‐term impact on the family. It is crucial to evaluate intervention program to help new parents cope with the stress of parenthood to reduce the risk of postpartum depression. The aim of this study was to explore the perceived benefits of the couple‐based psychoeducation to first‐time Hong Kong Chinese parents, and the crucial factors influencing the effectiveness of this program underpinned by the concept of process evaluation.MethodUsing an exploratory qualitative design, a purposeful sample of 27 couples who had participated in the program were interviewed at 1‐3 months postpartum. Data were collected using semi‐structured interviews and analysed by thematic analysis.FindingsThe findings showed that the parents perceived the program to be useful in enhancing their parenting skills and emotional control, and increasing their sense of support. The effectiveness of the program was facilitated by (a) the predisposing factors such as couple‐based approach to enhance mutual expectation and shared decision making when experiencing and managing challenges, and telephone follow‐up calls to sustain the continuity of care from hospital to the community, (b) the enabling factor for instance, the time of intervention arranged in non‐working hour, and (c) reinforcing factor namely involvement of midwives during program implementation and telephone follow‐up consultation.ConclusionsThe results of this study suggest the potential of the couple‐based psychoeducation to support first‐time parents in taking care of their children and controlling their emotions in this critical transition. The program could be integrated into maternal and child care services on a regular basis, and thus accessible to all first‐time parents.
Who Wears the Pants? Gender Identity Norms and Intrahousehold Financial Decision‐Making
Authors: KE DA 
Published: February 2021

ABSTRACTUsing microdata from U.S. household surveys, I document that families with a financially sophisticated husband are more likely to participate in the stock market than those with a wife of equal financial sophistication. This pattern is best explained by gender identity norms, which constrain women's influence over intrahousehold financial decision‐making. A randomized controlled experiment reveals that female identity hinders idea contribution by the wife. These findings underscore the roles of intrahousehold bargaining and traditional norms in shaping household financial decisions.
Isolation and characterization of Escherichia albertii in poultry at the pre‐harvest level
Authors: Hinenoya Atsushi , Li Xing‐Ping , Zeng Ximin , Sahin Orhan , Moxley Rodney A. , Logue Catherine M. , Gillespie Barbara , Yamasaki Shinji , Lin Jun 
Published: February 2021

AbstractEscherichia albertii, often misidentified as Escherichia coli, has become an emerging foodborne human enteric pathogen. However, the prevalence and major animal reservoirs of this significant pathogen are still not clear. Here, we performed comprehensive microbiological, molecular, comparative genomics and animal studies to understand the status and features of E. albertii in the US domestic and food animals. Although no E. albertii was identified in a total of 1,022 diverse E. coli strains isolated from pets and food animals in a retrospective screening, in a pilot study, E. albertii was successfully isolated from a broiler farm (6 out of 20 chickens). The chicken E. albertii isolates showed clonal relationship as indicated by both pulsed‐field gel electrophoresis (PFGE) and whole‐genome sequence analysis. The isolated chicken E. albertii displayed multidrug resistance; all the resistance determinants including the extended‐spectrum beta‐lactamase gene, carried by plasmids, could be conjugatively transferred to E. coli, which was further confirmed by S1‐PFGE and Southern hybridization. Whole‐genome sequence‐based phylogenetic analysis showed the chicken E. albertii strains were phylogenetically close to those of human origins. Challenge experiment demonstrated that the E. albertii strains isolated from human and wild bird could successfully colonize in the chicken intestine. Together, this study, for the first time, reported the isolation of E. albertii in poultry at the pre‐hrvest level. The findings from multi‐tier characterization of the chicken E. albertii strains indicated the importance of chickens as a reservoir for E. albertii. A large scale of E. albertii survey in poultry production at the pre‐harvest level is highly warranted in the future.
Beyond the Motor Domain: Exploring the Secondary Effects of a Fundamental Motor Skill Intervention for Children With Autism Spectrum Disorder
Authors: Elliott Leanne K. , Weiss Jonathan A. , Lloyd Meghann 
Published: February 2021

Early motor skill interventions have been shown to improve the motor skill proficiency of children with autism spectrum disorder; however, little is known about the secondary effects associated with these types of interventions (e.g., influence on behavior, social skills, family dynamics). The purpose of this qualitative study was to (a) investigate parents’ perceptions of the child-level benefits associated with a fundamental motor skill intervention for their 4-year-olds with autism spectrum disorder and (b) explore how child-level benefits influenced the family unit. Eight parents (N = 8) were interviewed (semistructured) about their experiences with the intervention for their child(ren); the study was grounded in phenomenology. Five main child-level benefits emerged, including improvements with (a) motor skills, (b) social skills, (c) listening skills, (d) turn-taking skills, and (e) transition skills. The child-level benefits then extended to family members in a number of ways (e.g., more positive sibling interactions). These findings highlight several important secondary effects that should be investigated in future research.
An extreme climate gradient-induced ecological regionalization in the Upper Cretaceous Western Interior Basin of North America
Authors: Burgener Landon , Hyland Ethan , Griffith Emily , Mitášová Helena , Zanno Lindsay E. , Gates Terry A. 
Published: February 2021

Abstract
The Upper Cretaceous Western Interior Basin of North America provides a unique laboratory for constraining the effects of spatial climate patterns on the macroevolution and spatiotemporal distribution of biological communities across geologic timescales. Previous studies suggested that Western Interior Basin terrestrial ecosystems were divided into distinct southern and northern communities, and that this provincialism was maintained by a putative climate barrier at ∼50°N paleolatitude; however, this climate barrier hypothesis has yet to be tested. We present mean annual temperature (MAT) spatial interpolations for the Western Interior Basin that confirm the presence of a distinct terrestrial climate barrier in the form of a MAT transition zone between 48°N and 58°N paleolatitude during the final 15 m.y. of the Cretaceous. This transition zone was characterized by steep latitudinal temperature gradients and divided the Western Interior Basin into warm southern and cool northern biomes. Similarity analyses of new compilations of fossil pollen and leaf records from the Western Interior Basin suggest that the biogeographical distribution of primary producers in the Western Interior Basin was heavily influenced by the presence of this temperature transition zone, which in turn may have impacted the distribution of the entire trophic system across western North America.
Developing a multimodal biosensor for remote physiological monitoring
Authors: Smith Michael , Withnall R , Anastasova S , Gil-Rosa B , Blackadder-Coward J , Taylor N 
Published: February 2021

IntroductionSeveral UK military expeditions have successfully used physiological sensors to monitor participant’s physiological responses to challenging environmental conditions. This article describes the development and trial of a multimodal wearable biosensor that was used during the first all-female unassisted ski crossing of the Antarctic land mass. The project successfully transmitted remote real-time physiological data back to the UK. The ergonomic and technical lessons identified have informed recommendations for future wearable devices.MethodThe biosensor devices were designed to be continuously worn against the skin and capture: HR, ECG, body surface temperature, bioimpedance, perspiration pH, sodium, lactate and glucose. The data were transmitted from the devices to an android smartphone using near-field technology. A custom-built App running on an android smartphone managed the secure transmission of the data to a UK research centre, using a commercially available satellite transceiver.ResultsReal-time physiological data, captured by the multimodal device, was successfully transmitted back to a UK research control centre on 6 occasions. Postexpedition feedback from the participants has contributed to the ergonomic and technical refinement of the next generation of devices.ConclusionThe future success of wearable technologies lies in establishing clinical confidence in the quality of the measured data and the accurate interpretation of those data in the context of the individual, the environment and activity being undertaken. In the near future, wearable physiological monitoring could improve point-of-care diagnostic accuracy and inform critical medical and command decisions.
Painlevé analysis, group invariant analysis, similarity reduction, exact solutions, and conservation laws of Mikhailov–Novikov–Wang equation
Authors: Ray S. Saha 
Published: February 2021

In this paper, for the study of integrability, symmetry analysis, group invariant solutions and conservation laws, the Mikhailov–Novikov–Wang equation is considered. Firstly, Painlevé analysis is being employed to study the integrability properties for the considered equation so as to check the possibility that this equation passes the Painlevé test. Secondly, Lie group analysis is studied for finding the symmetries by using Lie classical group analysis method and to obtain its symmetry group, infinitesimal generator, Lie algebra commutation table, and similarity reductions. The vector fields and the symmetry reduction of this equation are calculated with the aid of Lie symmetry analysis. From the similarity reduction equation, some explicit exact solutions are derived. Finally, using the new conservation theorem proposed by Ibragimov [N. H. Ibragimov, A new conservation theorem, J. Math. Anal. Appl. 333 (2007) 311–328], the conservation laws of the aforesaid equation have been constructed.
Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies
Authors: Liang Yi , Jeganathan Sujeeve , Marastoni Stefano , Sharp Adam , Figueiredo Ines , Marcellus Richard , Mawson Amanda , Shalev Zvi , Pesic Aleksandra , Sweet Joan , Guo Haiyang , Uehling David , Gurel Bora , Neeb Antje , He Housheng Hansen , Montgomery Bruce , Koritzinsky Marianne , Oakes Samantha , de Bono Johann S. , Gleave Martin , Zoubeidi Amina , Wouters Bradly G. , Joshua Anthony M. 
Published: February 2021

Abstract

Purpose:
Although enzalutamide (ENZ) has been widely used to treat de novo or castration-resistant metastatic prostate cancer, resistance develops and disease progression is ultimately inevitable. There are currently no approved targeted drugs to specifically delay or overcome ENZ resistance.

Experimental Design:
We selected several ENZ-resistant cell lines that replicated clinical characteristics of the majority of patients with ENZ-resistant disease. A high-throughput pharmacologic screen was utilized to identify compounds with greater cytotoxic effect for ENZ-resistant cell lines, compared with parental ENZ-sensitive cells. We validated the potential hits in vitro and in vivo, and used knockdown and overexpression assays to study the dependencies in ENZ-resistant prostate cancer.

Results:
ABT199 (BCL-2 inhibitor) and IMD0354 (IKKB inhibitor) were identified as potent and selective inhibitors of cell viability in ENZ-resistant cell lines in vitro and in vivo which were further validated using loss-of-function assays of BCL-2 and IKKB. Notably, we observed that overexpression of BCL-2 and IKKB in ENZ-sensitive cell lines was sufficient for the emergence of ENZ resistance. In addition, we confirmed that BCL-2 or IKKB inhibitors suppressed the development of ENZ resistance in xenografts. However, validation of both BCL-2 and IKKB in matched castration-sensitive/resistant clinical samples showed that, concurrent with the development of ENZ/abiraterone resistance in patients, only the protein levels of IKKB were increased.

Conclusions:
Our findings identify BCL-2 and IKKB dependencies in clinically relevant ENZ-resistant prostate cancer cells in vitro and in vivo, but indicate that IKKB upregulation appears to have greater relevance to the progression of human castrate-resistant prostate cancer.
Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles
Authors: Tošić Isidora , Heppler Lisa N. , Egusquiaguirre Susana P. , Boehnke Natalie , Correa Santiago , Costa Daniel F. , Moore Elizabeth A. Grossman , Pal Sharmistha , Richardson Douglas S. , Ivanov Alexander R. , Haas-Kogan Daphne A. , Nomura Daniel K. , Hammond Paula T. , Frank David A. 
Published: February 2021

Abstract
The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers, including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to target directly, we considered whether metabolic changes driven by activated STAT3 could provide a therapeutic opportunity. We found that STAT3 prominently modulated several lipid classes, with most profound effects on N-acyl taurine and arachidonic acid, both of which are involved in plasma membrane remodeling. To exploit these metabolic changes therapeutically, we screened a library of layer-by-layer (LbL) nanoparticles (NPs) differing in the surface layer that modulates interactivity with the cell membrane. We found that poly-l-glutamic acid (PLE)–coated NPs bind to STAT3-transformed breast cancer cells with 50% greater efficiency than to nontransformed cells, and the heightened PLE-NP binding to TNBC cells was attenuated by STAT3 inhibition. This effect was also observed in densely packed three-dimensional breast cancer organoids. As STAT3-transformed cells show greater resistance to cytotoxic agents, we evaluated whether enhanced targeted delivery via PLE-NPs would provide a therapeutic advantage. We found that cisplatin-loaded PLE-NPs induced apoptosis of STAT3-driven cells at lower doses compared with both unencapsulated cisplatin and cisplatin-loaded nontargeted NPs. In addition, because radiation is commonly used in breast cancer treatment, and may alter cellular lipid distribution, we analyzed its effect on PLE-NP–cell binding. Irradiation of cells enhanced the STAT3-targeting properties of PLE-NPs in a dose-dependent manner, suggesting potential synergies between these therapeutic modalities. These findings suggest that cellular lipid changes driven by activated STAT3 may be exploited therapeutically using unique LbL NPs.
Redescription of the fish-parasitic isopod Cymothoa ianuarii Schioedte & Meinert, 1884 and further records of C. excisa Perty, 1833 and C. oestrum (Linnaeus, 1758) (Isopoda: Cymothoida: Cymothoidae) from Brazil
Authors: Ribeiro Felipe Bezerra , Huber Augusto Frederico , Araujo Paula Beatriz 
Published: February 2021

Cymothoa ianuarii Schioedte & Meinert, 1884 is rediscovered almost 136 years after its original description and redescribed from specimens collected in the state of São Paulo. This species is mainly characterized by adult females with cephalon with conspicuous eyes and not deeply immersed in pereonite 1, pereonites 5-6 much wider than 4, pleotelson twice as wide as long and pleopods 1-5 decreasing in size; Cymothoa excisa Perty, 1833 and C. oestrum (Linnaeus, 1758) are recorded from the state of Bahia. Illustrations and an updated distribution map for these species in Brazil are provided.
Assessment of threat status of the holly fern Cyrtomium micropterum (Kunze) Ching (Polypodiopsida: Dryopteridaceae) in India using IUCN Regional guidelines
Authors: Bagathsingh C. , Benniamin A. 
Published: February 2021

During the field survey in central Western Ghats of India, an interesting dryopteridoid fern species was collected from Nellikathrupodu Range of Billigiri Rangaswamy Temple (BRT) Tiger Reserve of Karnataka. After a critical study of literature, the specimen was identified as Cyrtomium micropterum (Kunze) Ching. In India, this species is known only from its type locality Nilgiri and Palani hills of Tamil Nadu. The present collection from the BRT Tiger Reserve shows its extended distribution and forms the first report for the state of Karnataka. The present paper deals with the assessment and conservation status of Cyrtomium micropterum (Kunze) Ching in India in accordance with IUCN guidelines for the application of Red List Criteria at regional and national Levels, 2012, Version 4.0. Detailed descriptions, photographs, microphotographs are provided for easy identification of this species.