bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency
Authors: Cudrici Cornelia D , Newman Kam A , Ferrante Elisa A , Huffstutler Rebecca , Carney Katherine , Betancourt Blas , Miettinen Markku , Siegel Richard , Katz James D , Nesti Leon J , St Hilaire Cynthia , Lakshmipathy Deepak , Wen Han , Bagheri Mohammad H , Boehm Manfred , Brofferio Alessandra 
Published: March 2021

Abstract

Objectives
Arterial calcification due to deficiency of CD73 (ACDC) is a hereditary autosomal recessive ectopic mineralization syndrome caused by loss-of-function mutations in the ecto-5′-nucleotidase gene. Periarticular calcification has been reported but the clinical characterization of arthritis as well as the microstructure and chemical composition of periarticular calcifications and SF crystals has not been systematically investigated.

Methods
Eight ACDC patients underwent extensive rheumatological and radiological evaluation over a period of 11 years. Periarticular and synovial biopsies were obtained from four patients. Characterization of crystal composition was evaluated by compensated polarized light microscopy, Alizarin Red staining for synovial fluid along with X-ray diffraction and X-ray micro tomosynthesis scanner for periarticular calcification.

Results
Arthritis in ACDC patients has a clinical presentation of mixed erosive-degenerative joint changes with a median onset of articular symptoms at 17 years of age and progresses over time to the development of fixed deformities and functional limitations of small peripheral joints with, eventually, larger joint and distinct axial involvement later in life. We have identified calcium pyrophosphate and calcium hydroxyapatite (CHA) crystals in SF specimens and determined that CHA crystals are the principal component of periarticular calcifications.

Conclusion
This is the largest study in ACDC patients to describe erosive peripheral arthropathy and axial enthesopathic calcifications over a period of 11 years and the first to identify the composition of periarticular calcifications and SF crystals. ACDC should be considered among the genetic causes of early-onset OA, as musculoskeletal disease signs may often precede vascular symptoms.
The platform economy matures: measuring pervasiveness and exploring power
Authors: Kenney Martin , Bearson Dafna , Zysman John 
Published: March 2021

Abstract
Online platforms are pervasive and powerful in today’s economy. We explore the increased centrality of platforms in two ways. First, we measure the extent to which platforms are insinuating themselves into the economy. We accomplish this by analyzing the presence of platforms as intermediating organizations across all US service industries at the six-digit North American Industry Classification System code level. Our results show that 70% of service industries, representing over 5.2 million establishments, are potentially affected by one or more platforms. Secondly, we undertake a detailed firm-level case study of the mega-platform, Amazon, which demonstrates the ways that the aforementioned macro-level data is expressed by a single platform firm. This case study shows that Amazon’s growth trajectory has resulted in it entering and transforming existing industries and sectors. We conclude by reflecting upon the limitations and implications for future research.
Draft Genome Sequence Resource for the Orange Rust Pathogen of Sugarcane Puccinia kuehnii (Retracted)
Authors: Cardenas Daniela E. , Cheema Jitender , Oppelaar Theodora S. , Hincapie Martha , Sood Sushma , Zheng Qiaolin , Carrillo-Tarazona Yisel , Huguet-Tapia Jose , Saunders Diane G. O. , Comstock Jack C. , Rott Philippe C. , Cano Liliana M. 
Published: March 2021

The authors of Cardenas et al. 111:1893-1896 (2021) retracted this article because posterior analyses have identified that the assembled genomes contained a substantial proportion of other fungi beyond the orange rust Puccinia kuehnii, mainly Ascomycetes for one isolate and Ustilaginales for the other (metagenomes). This article was retracted on 11 March 2022. Puccinia kuehnii is an obligate biotrophic fungal pathogen that causes orange rust of sugarcane, which is prevalent in many countries around the globe. In the United States, orange rust was first detected in sugarcane in Florida in 2007 and poses a persistent and economically damaging threat to the sugarcane industry in this region. Here, we generated the first genome assemblies for two isolates of P. kuehnii (1040 and 2143) collected in Florida in 2017 from two sugarcane cultivars, CL85-1040 and CP89-2143, respectively. These two rust genome resources will be of immense value for future genomic studies, particularly further exploration of the predicted secretomes that may help define key pathogenicity determinants for this economically important pathogen.
Low birth weight female piglets show altered intestinal development, gene expression, and epigenetic changes at key developmental loci
Authors: Ayuso Miriam , Irwin Rachelle , Walsh Colum , Van Cruchten Steven , Van Ginneken Chris 
Published: March 2021

AbstractIntestinal development is compromised in low birth weight (LBW) pigs, negatively impacting their growth, health, and resilience. We investigated the molecular mechanisms of the altered intestinal maturation observed in neonatal and juvenile LBW female piglets by comparing the changes in intestinal morphology, gene expression, and methylation in LBW versus normal birth weight (NBW) female piglets. A total of 16 LBW/NBW sibling pairs were sacrificed at 0 hours, 8 hours, 10 days, and 8 weeks of age. The gastrointestinal tract was weighed, measured, and the small intestine was sampled for histomorphology, gene expression, and methylation analyses. Impaired intestinal development, with shorter villi and shallower crypts, was observed in LBW female piglets. The expression of intestinal development markers (ALPI and OLFM) rapidly peaked after birth in NBW but not in LBW female piglets. The lower expression of genes involved in nutrient digestion (ANPEP and SI) and barrier function (OCLN and CLDN4) in LBW, together with their delayed development of intestinal villi and crypts could help to explain the compromised health and growth potential of LBW female piglets. The changes in methylation observed in LBW in key regulators of intestinal development (OLFM4 and FZD5) suggest long‐term effects of BW on intestinal gene expression, development, and function. Accordingly, experimental demethylation induced in IPEC‐J2 cells led to increased expression of intestinal genes (MGA, DPP4, and GLUT2). Overall, we have identified the alterations in transcription or epigenetic marking at a number of genes critical to intestinal development, which may contribute to both the short‐ and long‐term failure of LBW female piglets to thrive.
Effects of a Video Game–Based Program on Women With Lymphedema Secondary to Breast Cancer: Preexperimental Study
Authors: Martínez de Albéniz Santamaría Noelia , Santamaría-Vázquez Montserrat , Ortiz-Huerta Juan Hilario 
Published: March 2021

Objective:
To improve the scapulohumeral joint limitations and increase the health-related quality of life (HRQOL) in women with lymphedema secondary to breast neoplasms.

Methods:
A preexperimental design (with pre- and posttest evaluations in only one group) was conducted in a group of 11 women with lymphedema secondary to breast cancer. They received 5 individual weekly sessions of 30 minutes each performed with the Wii console and the Wii Balance Board.

Measurements:
The Oxford Shoulder Score and the Shoulder Pain and Disability Index were used for the data measurements of both shoulder pain and disability; Functional Assessment of Cancer Therapy Questionnaire General and Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer were used to evaluate HRQOL; muscle strength was tested with an electronic manual dynamometer and range of motion by manual goniometry.

Results:
Statistically significant improvements were reported: pain (P = .011), disability (P > .05), HRQOL associated with lymphedema (P = .016), strength (P < .05), and range of articular motion (P < .05).

Conclusions:
The results suggest that a video game–based program is useful for addressing limitations relating to lymphedema and require further investigation.
Resonance Effect of the Frontal Sinus on Ocular Vestibular-Evoked Myogenic Potential Recordings
Authors: Lin Kuei-You , Jaw Fu-Shan , Young Yi-Ho 
Published: March 2021

Objective:
This study performed ocular vestibular-evoked myogenic potential (oVEMP) test via Fpz bone vibration (termed Fpz-oVEMP) and Fz bone vibration (termed Fz-oVEMP) using a minishaker. The aim of this study was to evaluate the resonance effect of the frontal sinus on the oVEMP recordings, so as to establish an optimal clinical protocol for eliciting oVEMPs by bone vibration.

Design:
Thirty healthy volunteers (15 children and 15 adults) and 15 adults with frontal sinusitis were enrolled in this study. All subjects underwent oVEMP test via Fpz and Fz bone vibration stimuli, and volume of the frontal sinus was measured by CT scan.

Results:
Because healthy adults (3.20 ± 1.08 mL) had significantly larger frontal sinus volume than healthy children (2.04±1.87 mL), the former (100%) showed higher response rates of Fpz-oVEMP than the latter (30%), but not Fz-oVEMP. When the frontal sinus volume is >1.91 mL (approximately at the age of 14 years), Fpz-oVEMP displayed larger reflex amplitude than Fz-oVEMP did. In contrast, Fpz-oVEMP (30%) displayed lower response rate than Fz-oVEMP (73%) in patients with frontal sinusitis.

Conclusions:
Both developmental (frontal sinus volume) and pathological (frontal sinus inflammation) factors may affect the oVEMP responses via altering resonance function. For the developmental factor, frontal sinus volume >1.91 mL may initiate the resonance effect on oVEMPs, as evidenced by higher response rate with larger reflex amplitude of Fpz-oVEMP than Fz-oVEMP. For the pathological factor, frontal sinusitis may hamper the resonance effect on oVEMPs, as shown by the lower response rate of Fpz-oVEMP than Fz-oVEMP. Hence, oVEMP test may be performed via Fpz bone vibration first in healthy adults, while via Fz bone vibration first in children aged under 14 years or subjects with frontal sinusitis.
A Randomized, Evaluator-Blind, Split-Face Study Evaluating the Safety and Efficacy of Calcium Hydroxylapatite for Jawline Augmentation
Authors: Boen Monica , Alhaddad Marwan , Goldman Mitchel P. , Kollipara Ramya , Hoss Elika , Wu Douglas C. 
Published: March 2021

INTRODUCTION
Jawline augmentation with calcium hydroxylapatite has not yet been evaluated in a prospective study with a split-face design. This study aims to perform the first randomized controlled, split-face study on the efficacy and safety of calcium hydroxylapatite for jawline augmentation using the needle and cannula technique.

OBJECTIVE
To perform the first randomized controlled, split-face study on the efficacy and safety of calcium hydroxylapatite for jawline augmentation using the needle and cannula technique.

MATERIALS AND METHODS
This is a single-site, randomized, evaluator-blind trial enrolling a total of 10 healthy subjects with at least Grade 1 (mild) on a 4-point Jawline Scale. One side of the face was randomized to receive 1 to 2 syringes of calcium hydroxylapatite with lidocaine (total of 3 mL) for correction of wrinkles and folds along the jawline using both the cannula and needle method, and a balancing treatment will be performed 1 month later. Blinded investigator and subject evaluations will be performed immediately after treatment and at the 30-, 60-, and 90-day visits.

RESULTS
Ten subjects were enrolled and completed the trial. There was a improvement in the degree of wrinkling and skin sagging in the 4-point Jawline Scale, with an average of a 1.3-point improvement in the scale on the day of treatment and at the Day 30 visit, which remained improved greater than baseline after 3 months as graded by blinded investigators. The Clinician Global Aesthetic Improvement Score for the treated side versus control, as assessed by blinded investigators, demonstrated a improvement with a 2.3-point improvement on the 5-point scale, and by the final visit on Day 90, most patients had a much improved appearance from baseline.

CONCLUSION
This study demonstrates that calcium hydroxylapatite is effective and safe for restoration and augmentation of the jawline using the unique needle and cannula technique.
ROLE OF OPTICAL COHERENCE TOMOGRAPHY FOR PREDICTING POSTOPERATIVE VISUAL OUTCOMES AFTER REPAIR OF MACULA-OFF RHEGMATOGENOUS RETINAL DETACHMENT
Authors: Guan Ivan , Gupta Mrinali P. , Papakostas Thanos , Wu Alan , Nadelmann Jennifer , D'Amico Donald J. , Kiss Szilard , Orlin Anton 
Published: March 2021

Purpose:
To identify any prognostic associations between preoperative optical coherence tomography findings and postoperative visual outcomes in patients with macula-off rhegmatogenous retinal detachment.

Methods:
A retrospective, single-center study of patients diagnosed with macula-off rhegmatogenous retinal detachment whom underwent surgical reattachment from 2012 to 2017. Optical coherence tomography images were analyzed by two retina surgeons. Outcome measures included “good” final vision (best-corrected visual acuity of 20/40 or better), “poor” final vision (best-corrected visual acuity of 20/200 or worse), and change in vision (worsened, improved, and improved ≥15 letters) at most recent follow-up. P values were calculated using t tests, analysis of variance, Wilcoxon rank-sum, or Kruskall–Wallis test.

Results:
A total of 49 eyes were included. There was a significant difference in the mean preoperative central retinal thickness between patients who had good final vision and patients who did not (96 μm vs. 161 μm, P = 0.048). In addition, a worse preoperative best-corrected visual acuity and greater subretinal fluid height were associated with vision improvement (P < 0.001). Those with persistent ellipsoid zone disruption postoperatively were less likely to have good final vision (odds ratio = 0.217, 95% confidence interval: 0.057–0.828).

Conclusion:
A lower mean preoperative central retinal thickness is associated with good visual prognosis. Eyes with ellipsoid zone disruption postoperatively were less likely to have good final vision. Future studies should include a larger cohort of patients and more optical coherence tomography variables to address the inconsistencies in the current literature.
Primary Graft Failure, Infection, and Endothelial Cell Density in Corneal Transplants With Increased Death-to-Preservation Time
Authors: Sun Michelle J. , Duong Andrew T. , Tran Khoa D. , Straiko Megan M.W. , Stoeger Christopher G. , Sales Christopher S. 
Published: March 2021

Purpose:
To ascertain whether death-to-preservation time (DPT) is associated with donor endothelial cell density (ECD), primary graft failure (PGF), and infection.

Methods:
Donor corneas aged older than 10 years with ECD 2000 to 4500 cells/mm2 were procured between 2011 and 2018 by a single eye bank. Donor corneas were analyzed retrospectively for the main outcome measures of PGF, infection, and ECD. Means and proportions of study parameters were compared between corneas with long and short DPT, defined as greater or less than 14 hours, respectively, excluding corneas with a history of intraocular surgery or diabetes. Multivariate analyses were performed using logistic regression, adjusting for donor age at time of death, history of diabetes mellitus, and history of cataract surgery.

Results:
Among 12,015 corneas, those with long DPT had a statistically but not clinically significant higher ECD than that of corneas with short DPT (2754 vs. 2724 cells/mm2, P < 0.01). There was no difference in PGF and infections in corneas with long versus short DPT (0.28% vs. 0.26%, P = 0.86; 0.43% vs. 0.29%, P = 0.51, respectively).

Conclusions:
Longer DPT is not associated with a clinically meaningful reduction in donor ECD, PGF, or infection.
Agreement of Corrected Intraocular Pressure Values Between Corvis ST and Pentacam in Patients With Keratoconus, Subclinical Keratoconus, and Normal Cornea
Authors: Chen Yanhui , Rong Hua , Liu Wei , Liu Guihua , Du Bei , Jin Chengcheng , Wei Ruihua 
Published: March 2021

Purpose:
To analyze the agreement of corrected intraocular pressure (IOP) values between Corvis ST (ΔIOP1) and Pentacam (ΔIOP2) in patients with keratoconus (KC), subclinical KC (sub-KC), and normal cornea.

Methods:
In total, 235 eyes were divided into KC, sub-KC, and control groups. Differences in ΔIOP1 (biomechanically corrected IOP minus uncorrected IOP) and ΔIOP2 (central corneal thickness-corrected amounts of IOP) were analyzed within and among groups. Topographical and biomechanical differences were compared among the 3 groups. Factors affecting differences between ΔIOP1 and ΔIOP2 were analyzed. Agreement analysis of ΔIOP2 and ΔIOP1 was performed by Bland–Altman plots for all 3 groups.

Results:
Mean ΔIOP1 was highest in the KC group (1.23 ± 0.84 mm Hg), followed by sub-KC and control groups (all P < 0.05). Deformation amplitude ratio at 2 mm (DA-2 mm), integrated radius, stiffness parameter at first applanation, and Corvis biomechanical index values significantly differed between sub-KC and control groups. The differences between ΔIOP1 and ΔIOP2 were affected by stiffness parameter at first applanation, after adjusting for central corneal thickness and age, in all 3 groups. The lowest agreement between ΔIOP2 and ΔIOP1 was observed in the KC group (mean difference: 1.90 mm Hg; 95% limit of agreement ranged from −0.2 to 3.9 mm Hg).

Conclusions:
Among the 3 groups in this study, the KC group exhibited the worst consistency between ΔIOP2 and ΔIOP1. For the sub-KC and control groups, corrected IOP values derived by Pentacam were similar to Corvis ST. Ophthalmologists should carefully consider the mechanical properties of eyes with KC during IOP management.
Interarm blood pressure differences and 2-year mortality in acute coronary syndrome patients
Authors: Kilic Ismail Dogu , Kilci Hakan , Sevgican Cihan Ilyas , Kilinc Mehmet , Ozden Tok Ozge , Oguz Ibrahim , Ghilencea Liviu , Senol Hande , Kilickesmez Orta Kadriye 
Published: March 2021

Background and aims
Interarm blood pressure difference (IABPD) was associated with increased cardiovascular and all-cause mortality in various cohorts previously. In this study, we planned to explore the association between the IABPD obtained with simultaneous measurements in both arms and the risk of mortality over a 2-year follow-up of patients with acute coronary syndrome (ACS).

Methods
Simultaneous blood pressure (BP) measurements were performed during initial admission in patients with ACS. Systolic ≥10 mmHg and diastolic ≥5 mmHg absolute IABPD was defined as cutoff values in this study. The relationship of IABPD and all-cause mortality was assessed using Kaplan–Meier curves and Cox analysis.

Results
A total of 532 patients with ACS were included in the study. Mean age of the study participants was 60.1 ± 12.6. Patients included in the study were followed for 23.2 ± 7.2 months (median 25.3, min: 0, max: 28.7 months). Survival was assessed using Kaplan–Meier curves. Patients with systolic IABPD ≥ 10 mmHg and systolic IABPD < 10 mmHg had an average survival time of 25.94 ± 0.84 and 25.92 ± 0.38 months (P = 0.925), respectively. Survival times of diastolic IABPD ≥5 mmHg and diastolic IABPD <5 mmHg were 26.44 ± 0.62 and 25.71 ± 0.41 (P = 0.251) months, respectively.

Conclusions
In the current study, we did not find a significant association between IABPD and all-cause mortality in patients with ACS in 2-years follow-up. Future studies may be required for further evaluation of the prognostic importance of IABPD in patients with ACS.
Effects of the valsartan/amlodipine combination and nifedipine gastrointestinal therapeutic system monotherapy on brachial pulse pressure and radial augmentation index in hypertensive patients
Authors: Xu Shao-Kun , Zeng Wei-Fang , Li Yan , Chen Liang-Long , Xie Jian-Hong , Wang Ji-Guang 
Published: March 2021

Objective
In a substudy of a randomized controlled trial, we investigated the effects of the valsartan/amlodipine single-pill combination and nifedipine gastrointestinal therapeutic system (GITS) monotherapy on brachial pulse pressure (bPP) and radial augmentation index (rAI) in patients with previously uncontrolled hypertension.

Methods
We performed measurements of clinic blood pressure (BP) and pulse rate and rAI (n = 63) and ambulatory BP monitoring (n = 42) at baseline and 12-week of follow-up. Analysis of covariance was performed to calculate the least square mean change from baseline and between-group differences [95% confidence interval (CI)]. Correlation analysis was performed to study the interrelationship between the changes in bPP and rAI and in pulse rate.

Results
After 12-week treatment, clinic and ambulatory SBP/DBP and pulse rate were not differently changed between the valsartan/amlodipine (n = 29) and nifedipine GITS groups (n = 34, P ≥ 0.06) except daytime SBP (P = 0.01). The reductions in 24-h and daytime ambulatory bPP were significantly greater in the former than the latter group (P ≤ 0.04). rAI increased slightly by 3.5% (P = 0.20) and 5.2% (P = 0.06) in the valsartan/amlodipine and nifedipine groups, respectively, with a between-group difference of −1.7% (95% CI −9.6 to 6.1%, P = 0.66). In the two groups combined, the changes in clinic and ambulatory bPP were not or weakly associated with that in clinic or ambulatory pulse rate (r = −0.14 to 0.36, P = 0.02–0.95), while the changes in rAI were more strongly or significantly associated with that in clinic or ambulatory pulse rate (r = −0.39 to −0.23, P = 0.02–0.16).

Conclusions
Antihypertensive drug-induced changes in rAI but not bPP were dependent on pulse rate.
A brief experimental examination of post-exercise hypotension and the impact of calculation method
Authors: Nguyen Cindy H. , Thomas Scott H. , Bentley Danielle C. 
Published: March 2021

Purpose
There is great variability in the reported values of post-exercise hypotension (PEH), with inconsistent calculation methods employed across primary research. This study aimed to explore the influence of the mathematical calculation method on PEH variability, with the hypothesis that the method of identifying the lowest single reduction point (LSRP) would yield false-positive results.

Methods
Young, normotensive (108 ± 7/69 ± 5 mmHg), apparently healthy, male (n = 20) were included in this study. Participants completed three random-order experimental sessions, with blood pressure and heart rate measured before (10 min) and after (30 min) an acute bout of either isometric handgrip exercise, aerobic cycling, or a nonexercise control. Three PEH calculation methods were analyzed: LSRP, 30-min average across the full post-exercise recovery, and 15-min binned averages with two recovery windows (0–15 min, 15–30 min).

Results
The only calculation method to consistently identify PEH was the LSRP method, which identified PEH for SBP, DBP, and mean arterial pressure, across handgrip exercise, aerobic cycling, and even nonexercise control (P < 0.001). All other calculation methods inconsistently identified PEH across experimental sessions, supporting the hypothesis that LSRP inaccurately overreports PEH.

Conclusion
Mathematical calculation method appears to be one source of variability contributing to the inconsistency in reported PEH among young, healthy males. This brief experimental examination reveals that the LSRP method should be avoided as it inaccurately overreports PEH. Alternatively, binned averages of smaller time windows across the recovery period may be a potentially advantageous approach and require further examination to determine to ideal level of granularity.