bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous Micro-fragmented Adipose Tissue in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis
Authors: Wang Jun , Guo Hua-Juan , Wang Cong-Cong , Zeng Xian-Wei , Wu Jun , Wang Xiao , Li Wei 
Published: December 2021

Abstract
Background: Microfragmented adipose tissue (MFAT)-containing mesenchymal stem cells (MSCs) combined with surgery is a promising strategy for the early management of knee osteoarthritis (KOA). This study aimed to explore the efficacy and safety of autologous MFAT-MSCs for the management of knee KOA.Methods: PubMed, Embase, the Cochrane Library, and Web of Science for potentially eligible studies published up to June 2021. The primary outcome was the Knee injury and Osteoarthritis Outcome Score (KOOS). The secondary outcomes were pain assessed by visual analog scale (VAS)/numeric rating scale (NRS), quality of life (QOL) (apart from the KOOS), and adverse events (AEs). The random-effects model was used in all analyses.Results: Eight studies (331 patients) were included. The mean differences in KOOS scores between pre-operation and post-operation (mean, 95%CI) were 22.1 (18.7, 25.3), 19.5 (15.4, 23.6), 23.0 (19.0, 26.9), 30.8 (25.5, 35.8), and 29.9 (24.8, 35.0) for pain, symptoms, ADL, sports/recreation, and QOL, respectively. The mean differences in pain VAS between pre-operation and post-operation were -3.026 (-3.884, -2.202). The mean differences in QOL between pre-operation and post-operation (mean, 95%CI) were -25.10 (-29.95, -20.20), 0.039 (-0.079, 0.170), and 0.33 (-0.99, 1.6) for the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), EQ-5D, and University of California in Los Angeles (UCLA), respectively. The use of MFAT-MSCs was not associated with bruising, bleeding, hematoma, drainage, infection, and swelling but was associated with soreness, pain, and stiffness.Conclusions: MFAT-MSC has potential benefits for KOA while being safe. A long-term follow-up and randomized controlled trials are necessary for confirmation.
A Cork Cell Wall Approach To Swelling And Boiling
Authors: Poeiras Ana Patrícia , Voguel Cordula , Günther Björn , Camilo-Alves Constança , Surový Peter , Silva Maria Emília , Ribeiro Nuno de Almeida 
Published: December 2021

Abstract
The bark of cork oak (Quercus suber L.) is mostly used for cork stopper production, whereas bark is undergoing a series of industrial procedures, boiling usually leading to changes in the characteristics of the tissue. Trees are traditionally grown under natural conditions; however, irrigation is now being used in plantations. These permanent water availability affects cork-oak development, while its effects on industrial procedures is unknown. This study provides a first insight into the behaviour of the cell walls of cork during the process of swelling and boiling when trees have been grown under irrigation, subject to a specific water regime. Cork tissue was analysed using environmental and scanning electron microscopy under three regimes: raw conditions; following immersion in water; and after boiling. Additionally, the radial expansion of samples was determined. The results showed greater cell-wall expansion in cork from the irrigated site than cork from the traditional rainfed plot, when hydrated for 24h. After boiling, the cell walls of the rainfed site were thinner than in the raw stage, in contrast to the irrigated cork. This study suggests that irrigation during cork-oak growth produces a higher capacity for adsorption, increasing cell-wall thickness from the raw stage to the boiling stage.
Investigating The Effect of Psychological Variables On Postoperative Pain In Children
Authors: Gholami Sara , Mojen Leila Khanali , Rassouli Maryam , Farahani Azam Shirinabadi , Dadashi Nasrin 
Published: December 2021

Abstract
Background and Purpose: Despite the progress of pain management in children, the prevalence of postoperative pain remains a caring challenge. Given the multidimensional nature of pain and the effect of various factors on pain, the need to identify risk factors in preventing postoperative pain is felt. The purpose of this study was therefore to investigate the effect of psychological variables on postoperative pain in childrenMethods: This study was conducted following a descriptive-correlational study design. The samples of the study were 171 children aged 6-13 years who were conveniently selected from the selected children's hospital in Tehran according to the inclusion criteria. Data were collected using the “demographic questionnaire”, “Child Pain Anxiety Symptoms Scale (CPASS)”, the Spielberger’s State-Trait Anxiety Inventory (STAI), and “Coping Strategies Questionnaire (CSQ)” and analyzed using SPSS21 software.Results: Most of the 171 children participated were boys (65.5%) with a mean age of 9.58 years. The most common type of surgery was abdominal (53.2%), with an average surgery duration of 134.29 minutes. The results of regression analysis showed that postoperative pain was positively affected by child and parent anxiety and negatively affected by coping strategies. The postoperative pain increased 0.31 and 0.30 per unit increase in child and parent anxiety, respectively, and decreased 0.14 per unit increase in coping strategies.Conclusion: Based on the confirmation of the relationship between child and parent psychological variables on postoperative pain, identifying children at risk and presenting psychological interventions can be an effective step for managing postoperative pain and improving child and family comfort.
Oxytocin Receptor Gene Methylation as a Molecular Marker for Severity of Depressive Symptoms in Affective Disorder Patients
Authors: Ludwig Birgit , Carlberg Laura , Kienesberger Klemens , Swoboda Patrick , Swoboda Marleen , Bernegger Alexandra , Koller Romina , Inaner Michelle , Fuxjäger Monika , Zotter Melanie , Schmelzle Nicolas , Senft Birgit , Meisner Lisa , Fischer-Hansal Daniela , Huber Jasmin , Schönthaler Silvia , Kapusta Nestor D. , Haslacher Helmuth , Aigner Martin , Weinhaeusel Andreas , Kasper Siegfried , Schosser Alexandra 
Published: December 2021

Abstract
Background: Oxytocin (OXT) is a neuropeptide and hormone involved in emotional functioning and also seems to play a role in moderating the stress response. Both preclinical and clinical studies point to an increased methylation status of the Oxytocin receptor (OXTR) promoter region with concomitant deficits in social, cognitive and emotional functioning. We hypothesize that methylation levels (%) of the oxytocin receptor promoter region correlate with the severity of depression symptoms within this present sample of affective disorder patients. Methodology: Eight hundred forty six Caucasian affective disorder patients were recruited at the Department of Psychiatry and Psychotherapy of the Medical University Vienna, the Karl Landsteiner University for Health and Science and Zentrum für seelische Gesundheit, BBRZ-Med Leopoldau. The assessment included an assemblage of psychiatric interviews (e.g. SCAN, HAMD, CTQ) and concomitantly DNA samples of peripheral blood cells were collected for Multiplexed and Sensitive DNA Methylation Testing. Results: Our data suggests a positive but not significant association between OXTR promoter Exons 1-3 methylation levels and severity of depression symptoms in affective disorder patients. Conclusions: Our findings contribute to elucidate the role of OXTR in affective disorders, but further longitudinal studies in particular are necessary to broaden the current state of knowledge.
Impact of Dexmedetomidine On Secondary Hyperparathyroidism Recurrence In Uremic Patients Who Received Parathyroidectomy With Auto-Transplantation: A Retrospective Propensity-Matched Study
Authors: Wu Yun , Han Wei , Li Peikun , Hu Xianwen , Zhang Ye 
Published: December 2021

Abstract
Background: Recurrence of secondary hyperparathyroidism (SHPT) remains a big challenge in uremic patients who underwent total parathyroidectomy with auto-transplantation (tPTX-AT). However, the relationship between perioperative intervention and recurrence of SHPT remains unclear. Dexmedetomidine has been used safely and effectively in uremic patients’ anesthesia. The aim of the study was to explore the effect of dexmedetomidine on the recurrence of SHPT and speculate the possible mechanism of action.Methods: Records of patients who underwent tPTX-AT between 2017 and 2018 were retrospectively analyzed. The study consisted of patients who received dexmedetomidine intra-operatively and the controls were patients who did not receive dexmedetomidine. The primary endpoint was the difference in the recurrence of SHPT one year after surgery between the two groups. The secondary endpoint was health-related quality of life scores. Analysis included propensity score matching and multivariable logistic regression. Results: Of 354 patients, 133 patients received dexmedetomidine intraoperatively, and the total recurrence rate of SHPT was 10.2%. After propensity score matching, patients who received dexmedetomidine had a 3.80-fold decreased risk of SHPT recurrence (odds ratio, 0.263; 95% confidence interval, 0.081 to 0.854; P=0.026) and exhibited a better quality of life in terms of physical functioning and general health, and less emotional role limitations compared with those in control group.Conclusion: In uremic patients who received tPTX-AT, there was an association between dexmedetomidine use and decreased risk of SHPT recurrence. Further studies are needed to accurately assess the effects and mechanism of action of dexmedetomidine on the prognosis of this population.
Cataract Progression Following Lens-Sparing Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment
Authors: Bellucci Carlo , Benatti Lucia , Rossi Maurizio , Tedesco Salvatore Antonio , Carta Arturo , Calzetti Giacomo , Gandolfi Stefano , Mora Paolo 
Published: December 2021

Abstract
Purpose: Lens-sparing pars plana vitrectomy (PPV) is often followed by cataract development. However, there have been few prospective studies evaluating the timing of cataract progression and potential associated factors.Methods: This was an observational study conducted at the Ophthalmology Unit of the University Hospital of Parma (Parma, Italy). Patients presenting with rhegmatogenous retinal detachment (RRD), who underwent PPV with preservation of the lens, were examined according to a scheduled follow-up (3, 6 and 12 months after PPV) and then preoperatively when cataract extraction surgery (CES) was indicated, or at the end of the study follow-up period (May 2021). The primary outcome was the interval between PPV and CES indication (based on predefined refractive criteria).Results: A total of 36 eyes of 36 patients (mean age: 52 ± 10 years) were included in the study. Nineteen eyes (53%) were indicated for CES a median of 14.5 months (IQR: 12.0–24.8) after PPV. The nuclear and posterior subcapsular forms of cataract progressed significantly starting at 6 months after PPV. Older age at the time of PPV, silicone oil tamponade and RRD without macular involvement were significantly and independently associated with an earlier indication for CES. Conclusions: Patient age and the use of silicone oil tamponade must be taken into consideration when evaluating the risk of cataract development after PPV.
Diversity And Population Structure of Nordic Potato Cultivars and Breeding Clones Grown Under Long Daylength in Europe
Authors: Selga Catja , Chrominski Pawel , Carlson-Nilsson Ulrika , Andersson Mariette , Chawade Aakash , Ortiz Rodomiro 
Published: December 2021

Abstract
The genetic diversity and population structure of breeding germplasm is central knowledge for crop improvement. To gain insight into the genetic potential of the germplasm used for potato breeding in a Nordic breeding program as well as the collections from the Nordic genebank (NordGen), 133 potato genotypes were genotyped using the Infinium Illumina 20K SNP array. After SNP filtering, 11 610 polymorphic SNPs were included in the analysis. In addition, data from three important breeding traits – percent dry matter and uniformity of tuber shape and eye – were scored to measure the variation be-tween groups. The genetic diversity among the genotypes was estimated using principal coordinate analysis based on the genetic distance between individuals, as well as by using the software STRUC-TURE. Both methods suggest that the collected breeding material and the germplasm from the gene-bank are closely related, with a low degree of population structure between the groups. The phenotypic distribution among the genotypes revealed significant differences, especially between farmer’s cultivars and released cultivars and breeding clones. The percent heterozygosity was similar between the groups, with a mean average of 58–60%. Overall, the breeding germplasm and the collection of genotypes from the Nordic gene bank seems to be closely related with similar genetic background. This gains insight that the genetic potential of available Nordic potato breeding germplasm is low, and for genetic hybridi-zation purposes, genotypes from outside the Nordic region should be employed.
The Effect of Monocyte Count on Disease-Free Survival in Esophageal Cancer Patients
Authors: Kalkan Nurhan Önal , Çakıroğlu Umut 
Published: December 2021

Abstract
Background: Inflammation plays a pivotal role in cancer development and prognosis. Peripheral blood test is a useful parameter in the evaluation of systemic inflammatory response. Previous studies have shown a relationship between monocyte count and prognosis in some solid tumors. The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival and prognosis in patients with esophageal cancer.Materials and Methods: The retrospective study included 145 patients with esophageal cancer who presented to Van Training and Research Hospital Medical Oncology outpatient clinic between January 2015 and September 2020. The effect of monocyte count assessed in the blood samples taken at the time of diagnosis prior to the initiation of the treatment on disease-free survival was investigated.Results: The Receiver Operating Characteristics (ROC) curve analysis determined a cut-off value of 515/μL for the monocyte count assessed at the time of diagnosis. Disease-free survival was 17.3 months (95% CI: 8.4-26.2) in patients with a monocyte count ≥515/μL as opposed to 38.5 months (95% CI: 28. 8-48.1) in patients with a monocyte count <515/μL. Moreover, low monocyte count at diagnosis was associated with significantly higher disease-free survival (p<0.001).Conclusion: It is considered that the proportional distribution of cells in peripheral blood count may reflect the severity of inflammation in the tumor microenvironment. Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype.
Mechanically driven SMR-based NEMS magnetoelectric antennas
Authors: Liang Xianfeng , Chen Huaihao , Sun Neville , Golubeva Elizaveta , Müller Cai , Mahat Sushant , Wei Yuyi , Dong Cunzheng , Zaeimbashi Mohsen , He Yifan , Gao Yuan , Lin Hwaider , Cahill David , Sanghadasa Mohan , McCord Jeffrey , Sun Nian 
Published: December 2021

Abstract
Mechanically driven magnetoelectric (ME) antennas have been demonstrated to be one of the most effective methods to miniaturise antennas compared to state-of-the-art compact antennas. However, the nanoelectromechanical systems (NEMS) ME antennas are fragile due to their suspended thin-film heterostructure, and have very low power handling capabilities. Here we show that solidly mounted resonator (SMR)-based NEMS ME antennas on a Bragg acoustic resonator, which have a circular resonating disk of 200 μm diameters and operate at 1.75 GHz, show a high antenna gain of -18.8 dBi and 1dB compression point (P1dB) of 30.4 dBm. Compared to same-size thin-film bulk acoustic resonator (FBAR) ME antennas with a free-standing membrane, the SMR-based antennas are much more structurally stable with 23.3 dB higher power handling capability and easier fabrication steps. These SMR-based ME antennas are fabricated with processes compatible with complementary metal-oxide-semiconductor (CMOS), exhibiting dramatic size miniaturisation, high power handling, high mechanical robustness, simple fabrication processes, and much higher antenna radiation gain compared to same-size state-of-the-art antennas.
The Importance of Hail Events for Landslides and Bedload Transport in Austrian Alpine Torrents
Authors: Schritter Mario , Glade Thomas 
Published: December 2021

Abstract
Landslides and bedload transport can be a threat to people, infrastructure, and vegetation. Many detailed hydrometeorological trigger mechanisms of such natural hazards are still poorly understood. This is in particular valid concerning hail as a trigger of these processes. Therefore, this study aims to determine the influence of hail on landslides and bedload transport in alpine torrents. Based on a generated table from an event register of mountain processes maintained by the Avalanche and Torrent Control Unit (WLV) and weather data provided by the Centre for Meteorology and Geodynamics (ZAMG), 1,573 observed events between 1980 and 2019 in 79 Austrian alpine sites are analysed. Thiessen polygons are used to regionalise local weather data to adjacent regions. The spatial extend of these regions are merged with the registered torrential events. As a result of a stepwise filtering of the used data, the final inventory was created.The results show that 95.1% of the investigated torrential processes triggered by hailstorms are debris flows or debris flow-like transports. Within the study period, a peak of hail-triggered landslides and bedload transport can be recognised in the first 10 days of August in all 39 years. Furthermore, the results suggest that hail is rather a direct than an indirect trigger for landslides and bedload transport.Overall, we conclude that the influence of hail on landslides and bedload transport is significant. Respective hydrometeorological triggering conditions should be included in any regions. Further research for this topic is required to explore the process dynamics in greater detail.
An Accurate Prognostic Model and Treatment for Pancreatic Carcinoma Based on the Tumor Immune Microenvironment
Authors: Wang Shujie , li zhenchong , liu chunsheng , zhou qi , ma zuyi , zhou zixuan , Zhuang Hongkai , Huang Shanzhou , Zhang Chanzhao , Hou Baohua 
Published: December 2021

Abstract
BackgroundPancreatic adenocarcinoma (PAAD) is a highly malignant cancer with a poor prognosis. The tumor microenvironment (TME) is closely related to tumorigenesis, progression, and treatment. However, the relationship between TME immune cell genes and prognosis in PAAD is currently unclear.Methodsn this study, we identified three prognostic subtypes based on the TME by using data from The Cancer Genome Atlas (TCGA) database, The International Cancer Genome Consortium (ICGC) database and University of California Santa Cruz (UCSC) database. The Silhouette plot analysis was used to evaluate 758 immune genes expression in PAAD from each database, then to divide all samples into three subtypes (Clusters A, B, C) by Lasso’s binomial logistic regression. We analyzed the relationship between subtypes and prognosis by the survival R package. CIBERSORT was used for evaluating the expression changes of immune cells. We detect the copy number variation areas between two groups through GISTIC 2.0 algorithm. The TIDE network tool was used to predict the response of immune therapy.ResultsWe defined three clusters (Clusters A, B, and C) based on the analysis of immune gene expression. Cluster B got a worse prognosis than the other two clusters. The Cluster B group had the highest level of Macrophages M0 and Macrophage M2. NK cell resting was much higher in Cluster B than other groups in TME. Gene KRAS was mutated in 77% of all samples. Cluster C had a better immune therapy effect than others.ConclusionsWe found a news model to predicted patients’ prognosis who with pancreatic adenocarcinoma. Cluster B had the significant worse prognosis than other groups. Patients in Cluster C could get batter treatment effect by using immunotherapy.
In Silico Screening for Novel Tyrosine Kinase Inhibitors With Oxindole Scaffold as Anticancer Agents: Design, QSAR Analysis, Molecular Docking and ADMET Studies
Authors: Zangeneh Jalalaldin , Shirvani Pouria , Etebari Mahmoud , saghaie lofollah 
Published: December 2021

Abstract
Recently, Anti-cancer targeting drugs are directed against specific molecules and signaling pathways. These targeting agents have reasonable specificity, efficacy, and less side effects. Tyrosine kinases, which play an essential role in growth factor signaling regulation, are significant targets in this type of therapy. Synthesized numerous tyrosine kinase inhibitors (TKIs), such as substituted indolin-2-ones, are effective as anti-tumor and anti-leukemia agents.In this study, a series of novel substituted indolin-2-ones were studied as kinase inhibitor analogs through quantitative structure-activity relationship (QSAR) analysis.Two chemometrics methods, such as multiple linear regression (MLR) and partial least squares combined with genetic algorithm for variable selection (GA-PLS), were employed to establish relationships between structural characteristics and kinase inhibitory activity of oxindole analogs. The GA-PLS was developed as the best predictor and validated QSAR model. The data set compounds were also studied by molecular docking to investigate their binding mechanism in the active site of tyrosine kinase enzymes. According to the information obtained from QSAR models and molecular docking analysis, 44 new potent lead compounds with novel structural features were introduced. Molecular docking, drug-likeness rules, ADMET analysis, bioavailability, toxicity prediction, and target identification were carried out on the newly designed oxindoles to elucidate the fundamental structural properties that affect their inhibitory activity. The results of our study could provide significant insight for future design and development of novel tyrosine kinase inhibitors.
The Application of Fuzzification for Solving Quadratic Functions
Authors: Gao Lunshan 
Published: December 2021

Abstract
This paper describes an approximation algorithm for solving standard quadratic optimization problems(StQPs) over the standard simplex by using fuzzification technique. We show that the approximate solution of the algorithm is an epsilon -critical point and satisfies epsilon-delta condition. The algorithm is compared with IBM ILOG CPLEX (short for CPLEX). The computational results indicate that the new algorithm is faster than CPLEX. Especially for infeasible problems. Furthermore, we calculate 100 instances for different size StQP problems. The numerical experiments show that the average computational time of the new algorithm for calculating the first local minimizer is in BigO(n) when the size of the problems is less or equal to 450.