bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bestuurlijke manie bij prestigeprojecten: van maquette naar mislukking
Authors: Verheul Wouter Jan , Bokhorst Meike 
Published: April 2021

Managerial mania at prestigious projects: from model to misfortune
Prestigious urban projects demonstrate many insights in the functioning of public administration. Especially, prestigious urban projects can teach us about what we call ‘managerial mania’. Following the perspective of behavioural public administration, this article observes significant characteristics of managerial mania, such as elated behaviour, an exaggerated positive self-image, infectious enthusiasm, selective argumentation, tunnel vision, and an unsubstantiated faith that plans will succeed. As a consequence of managerial mania, prestigious projects are at risk of cost overruns, project fiascos, or underdelivering the expected outcomes promised by politicians or top-level managers. This article explores the phenomenon of managerial mania based on examples of large and controversial urban projects. Furthermore, this article describes and analyses the symptoms of managerial mania, its implications, and its mechanisms. Finally, the authors suggest some means of restraining the most extreme forms of managerial mania.
Tien jaar arbeidsrecht (2010-2020)
Authors: Veling P.H. 
Published: April 2021

Tien jaar arbeidsrecht (2010-2020)
Wetgeving: Invoering van titel 7.10 NBW laat op zich wachten. Rechtspraak: Opschorting van loon bij niet-naleven controlevoorschriften bij ziekte vaste rechtspraak? Zorgplicht van de werkgever gaat ver. Statutair bestuurder van een rechtspersoon geen arbeidsovereenkomst ook niet als hij al in dienst was vóór zijn benoeming. ‘Service charge’ ook voor uitzendkrachten. Matiging van de loonvordering na nietig ontslag alleen als doorbetaling van het loon in gegeven omstandigheden tot onaanvaardbare gevolgen zou leiden. Matiging van de wettelijke verhoging behoort geen automatisme te zijn. Goed werkgeverschap. De dringende reden; het fixatiebeginsel. Cessantia als maatstaf voor schadevergoeding bij onregelmatig ontslag. Cessantia versus bedrijfspensioen. Afscheidsbeleid.
Practicing Response Surface Designs in Textile Engineering: Yarn Breaking Strength Exercise
Authors: Gönül Şengöz Nefise 
Published: April 2021

Predicting properties of end product from known properties of raw material is an important part of quality control in manufacturing. Main concept in this research is to reach a specified property of end product from known properties of raw material by attaining response surface designs with feasible region. The Ne20–19.21 T/inch yarn breaking strength (response, desired value 450 cNs) is acquired from cotton fiber properties (variables). The relationship between response and variables are obtained in response surface drawings and contour plots. The area showing the desired value in contour plots are colored in lilac and are intersected to obtain the feasible regions. By reading backwards from the feasible region borders, the variable value ranges are reached which will give the desired value of the response is obtained. When this information to start the yarn production is ready, the cotton lots containing these fiber property value ranges will be bought or from raw material in hand we will be read which yarn breaking strength will occur at the end of production. It was concluded that response surface designs with feasible region are quick, practical, and effective tools, provide valuable results, contribute a lot to quality control, and are beneficial in textile quality control.
Y a-t-il une isothanatie dans l’Athènes démocratique ?
Authors: Auberger Janick 
Published: April 2021

La démocratie athénienne est célèbre pour l’isonomia (égalité de tous face à la loi) et l’isègoria (égalité de tous face à la prise de parole). Qu’en est-il de l’égalité de tous face à la mort ? Loi de Nature, diront les uns. Est-ce pour cela que la cité semble se questionner sur elle et remettre en question ce que la Nature lui dictait ? La cité semble vouloir refuser cette loi de Nature et décider à sa place de la hiérarchie des morts.
La souffrance des soignants en soins palliatifs
Authors: Jacquemin Dominique 
Published: April 2021

Les soins palliatifs doivent répondre, en France, à une obligation de moyens dans la prise en charge des personnes en fin de vie. Faisant ainsi partie de l’imaginaire social, ils pourraient sembler en adéquation avec la volonté de nombreux soignants d’assumer au mieux cette ultime période de la vie. Cependant, un idéal – qui n’est pas à remettre en question – se trouve confronté aux limites du « bien faire » dans les pratiques. Divers décalages ont à être pensés et nommés pour reconnaître, rencontrer et accompagner la souffrance des soignants engagés dans ce type de soins.
Comprendre la douleur chronique pour éviter la douleur de l’incompréhension
Authors: Beauchamp Yvon 
Published: April 2021

La douleur chronique est présente quotidiennement dans toutes les sphères médicales. Les malades qui en sont atteints n’acceptent plus de souffrir et ne tolèrent plus que leurs soignants ignorent leurs douleurs. Souvent cette ignorance par les médecins du phénomène douloureux est le reflet de leur ignorance des mécanismes fondamentaux neuro-endocriniens de la douleur. Il est plus facile d’ignorer ou de nier l’existence de ce qu’on ne saurait expliquer. Malheureusement, comment et pourquoi apaiser ce qui ne pose pas problème pour certains médecins ?
L’accompagnement ou la leçon de transcendance avec Yourcenar
Authors: Parent Nathalie 
Published: April 2021

Cet article présente une étude sur le thème de la mort et de la transcendance dans deux nouvelles de Marguerite Yournecar tirées des Nouvelles orientales : La tristesse de Cornélius Berg et Comment Wang-Fô fut sauvé. On cherche ici à mettre en parallèle deux représentations de la mort, des derniers instants de la vie et de l’accompagnement. Une première représentation, celle de La tristesse de Cornélius Berg, met en scène une désacralisation du réel et la solitude dans la mort. Une seconde représentation, celle de Comment Wang-Fô fut sauvé, témoigne de l’apprentissage d’une nouvelle perception du monde et une mort transcendée dans un passage harmonieux et accompagné où le réel se fond à l’art.
L’exposition traditionnelle des défunts à Lévis (1920-1960)
Authors: Guay Caroline 
Published: April 2021

L’exposition des défunts à la maison était pratique courante dans les familles québécoises au début du XXe siècle. Les témoignages de personnes interrogées dans le cadre d’une enquête orale nous décrivent comment se passaient les choses à Lévis.
Le deuil dans la littérature
Authors: Reboul Hélène 
Published: April 2021

Plusieurs écrivains se sont servis de leur plume pour engager un travail de deuil à la suite du décès d’un proche. Parmi ceux-ci des auteurs très connus, tels que Simone de Beauvoir et Jean-Paul Sartre et d’autres qui le sont moins mais dont l’écrit présente un intérêt non négligeable : Anne Philipe ou Michel Ragon. Dans la mesure où la démarche de ces écrivains, réalisée avec leur sensibilité propre et une certaine liberté d’expression, retrace le vécu avec la personne disparue, ces écrits constituent des autobiographies. Celles-ci sous le terme de Mémoires contribuent également à faire le deuil des décennies passées. Parallèlement, l’auteur de l’article s’engage dans une démarche similaire grâce au choix des ouvrages et à l’intérieur de ceux-ci des circonstances relatées.
Le syndrome de Diogène
Authors: Naef Jean-Jacques 
Published: April 2021

Le « syndrome de Diogène », entité médico-psychosociale, définie en Angleterre il y a trente ans, nous interpelle en tant que soignant dans la communauté. La prise en charge de ces patients dans le refus conduisait à des intervention en urgence, alors que leur état de santé s’était dégradé à un point tel que les deux tiers devaient décéder lors de leur admission en milieu hospitalier. Ces patients dans le refus, l’isolement et la crasse, vivant comme des « clochards » à domicile nous préoccupent. Que faire pour diminuer cette mortalité catastrophique ? Ces personnes avaient-elles leur capacité de discernement ? Leur esprit n’était-il pas suffisamment perturbé pour que nous puissions nous passer de leur avis pour intervenir sans leur consentement ? À l’aide de quelques situations, nous essaierons de montrer que l’esprit de ces personnes est bien vivant et qu’il est possible de maintenir ces personnes à domicile et de diminuer de façon radicale les taux de mortalité observés.
Suicide, hommes et socialisation
Authors: Charbonneau Lucie , Houle Janie 
Published: April 2021

Depuis les années 70, au Québec, le taux de suicide des hommes a grimpé de 78 % et aujourd’hui, 80 % des suicides sont commis par des hommes. Pourquoi les hommes se suicident-ils plus que les femmes ? Plusieurs éléments contribuent à cette surmortalité, mais la socialisation masculine apparaît comme leur dénominateur commun. En effet, la socialisation masculine facilite l’apparition de facteurs de risque liés au suicide et empêche l’émergence de facteurs de protection. Comme société et comme individus, il nous faut réfléchir à nos pratiques et à nos attitudes face aux hommes en difficulté afin de créer un espace où leur souffrance pourra s’exprimer.
Preparation and Evaluation of Pan Bread from Chia Seeds Powder as Substitute Wheat Flour
Authors: Boriy G. E. , Yousef Eman A. , Rabou Eman A. A. Abd 
Published: April 2021

As part of this functional food covenant, the world is searching for new healthy food products with ample quantities of bioactive components such as fibre, mineral elements, essential amino acids, and phenols. Since CHIA seeds powder has both nutritious and pharmaceutical properties, integrating it into pan bread may be beneficial to human health. The sensorial parameters of pan bread enriched with CSP, amino acids composition, and proximate compositions of the pan bread were investigated in this study by partially replacing wheat flour (WF) with CHIA seeds powder (CSP) at levels of 3 percent, 6 percent, 9 percent, and 12 percent. The addition of CSP to pan bread improved the mineral content of the bread. With only a minor depreciation in bread quality, CSP could partially replace WF 72 percent extraction in pan bread, increasing its nutritional value in terms of fibre, essential amino acids, and minerals. Sensorial evaluation revealed that pan bread supplemented with up to 12% CSP was acceptable to the panelists, with notable differences in crumb texture, appearance, crust color, crumb grain, taste, odor, and overall acceptability as compared to pan bread control. When compared to pan bread without CSP, the CSP mixture increased the mineral content, essential amino acid content, and nutritional properties.
Evaluation of Antimicrobial activity and Genotoxic Potential of Capparis spinosa (L.) Plant Extracts
Authors: Adwan Ghaleb M. , Omar Ghadeer Ibrahim 
Published: April 2021

Objective: The aims of this study were to evaluate the antimicrobial activity and the genotoxic effect of both ethanolic and aqueous extracts of stem and leaf of Capparis spinosa (C. spinosa) plant on Escherichia coli (E. coli) ATCC 25922, Staphylococcus aureus (S. aureus) ATCC 6538P, clinical isolate of Methicillin-resistant S. aureus (MRSA) and Klebsiella pneumoniae (K. pneumoniae) and Candida albicans (C. albicans) ATCC 90028.
Materials and Methods: The antimicrobial activity was determined using microbroth dilution method, while the genotoxic effect was investigated using randomly amplified polymorphic DNA (RAPD)-PCR and enterobacterial repetitive intergenic consensus (ERIC)-PCR.
Results: The MIC values of both ethanolic and aqueous leaf and stem extracts of C. spinosa plant had a range 6.25 mg/ml to 100 mg/ml. In addition, it was found that ethanolic extract more effective than aqueous extract. The genotoxic activity of aqueous leaf extract, showed changes in both Random Amplified Polymorphic DNA (RAPD)-PCR and Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR profiles of E. coli strain treated with extract compared to untreated (negative) control. These changes included an alteration in the intensity, absence or appearance of new amplified fragments.
Conclusions: Results of this study strongly show the genotoxic effect of aqueous leaf extract from C. spinosa plant on E. coli. The findings draw awareness to the possible toxic effect use of C. spinosa plant in traditional medicine and point out the capability of using C. spinosa to treat bacterial or fungal infections. More studies are needed to detect the exact ingredients of this plant as well as the mechanisms responsible for genotoxicity. Further in vivo genotoxicity studies are recommended to ensure and to evaluate the safety of using plants for therapeutic purposes. In addition, results of this study showed that molecular fingerprinting based on ERIC-PCR can be used to evaluate the genotoxic effect in the model bacterial species E. coli.
Biocatalytic Application of a Membrane‐Bound Coumarin C‐Glucosyltransferase in the Synthesis of Coumarin and Benzofuran C‐Glucosides
Authors: Chen Dawei , Fan Shuai , Yang Zhaoyong , Dai Jungui 
Published: April 2021

AbstractA number of plant C‐glycosyltransferases (CGTs) have been recently identified, whereas the coumarin CGTs have not been found. Here we reported the first identification of a coumarin C‐glucosyltransferase MaCGT fromMorus alba. The whole‐cell biocatalyst harboring MaCGT was exploited and exhibited strictly and efficiently regio‐ and stereo‐specific C‐glucosylation capacity toward structurally different coumarins. The whole‐cell of MaCGT was further applied to chemo‐enzymatically synthesize benzofuran C‐glucosides. Moreover, MaCGT is reported as the first characterized membrane‐bound CGT from plants, although sequence homology search has shown other potentially membrane‐bound CGTs fromM. notabilis; and the presence of the transmembrane domain is critical for its catalytic activity and stability as demonstrated by the C‐glucosylation activity of truncated MaCGT proteins. In addition, the key residues involved in the C‐glucosylation of MaCGT were explored. These findings suggest the diversity of CGTs in the plant kingdom and demonstrate the significant potential of biocatalytic approach to produce structurally diverse C‐glycosides for drug discovery.magnified image
Manganese‐Catalyzed Selective Hydrogenative Cross‐Coupling of Nitriles and Amines to Form Secondary Imines
Authors: Li Xiao‐Gen , Zhou Qi‐Lin 
Published: April 2021

AbstractManganese complexes with tridentate PNN ligands have been synthesized as catalysts for hydrogenative cross‐coupling reaction of nitriles and amines to form secondary imines. This reaction afforded a variety of unsymmetrical secondary imines in good yields with excellent selectivity. Investigation of catalyst intermediates indicated that an amido manganese complex may be the active catalyst species for this reaction.magnified image
Growth and fecundity of colonizing hybrid Raphanus populations are environmentally dependent
Authors: Shukla Kruti , Laursen Andrew E. , Benavides Jessica , Ejbari Neda , Campbell Lesley G. 
Published: April 2021

PremiseHybrid gene pools harbor more genetic variation than progenitor populations. Thus, we expect hybrid populations to exhibit more dynamic evolutionary responses to environmental variation. We ask how environmental variation experienced by adapted and transplanted populations influence the success of late‐generation hybrid populations during invasion.MethodsFor four generations, 20 wild (Raphanus raphanistrum) and 20 hybrid radish (R. sativus × R. raphanistrum) plant populations evolved under experimentally manipulated moisture conditions (dry, wet, control‐sheltered, or control‐unsheltered plots; i.e., evolutionary environment) in old fields near Toronto, Canada. We planted advanced‐generation wild and hybrid radishes in sheltered plots and exposed them to either an evolutionary or a novel watering environment. To determine how soil moisture would influence invasion success, we compared the phenotype and fecundity of plants grown in these various environments.ResultsHybridization produced larger plants. In wet environments, hybrid seedlings emerged more frequently and expressed higher photosynthetic activity. Low‐moisture, novel conditions delayed and reduced seedling emergence frequency. Hybrid plants and those that evolved under relatively wet environments exhibited higher aboveground biomass. Hybrid plants from control‐sheltered plots colonizing novel moisture environments were more fecund than comparable wild plants.ConclusionsDry environments are less likely than other evolutionary environments to contribute colonists. However, relatively wet locations support the evolution of relatively fecund plants, especially crop‐wild hybrid populations. Thus, our results provide a strong mechanistic explanation for variation in the relative success of crop‐wild hybrids among study locations and a new standard for studies that assess the risk of crop‐wild hybridization events.
Cerebrovascular Neuroprotection after Acute Concussion in Adolescents
Authors: Aaron Stacey E. , Hamner Jason W. , Ozturk Erin D. , Hunt Danielle L. , Iaccarino Mary Alexis , Meehan William P. , Howell David R. , Tan Can Ozan 
Published: April 2021

ObjectiveTo assess acute cerebrovascular function in concussed adolescents (14–21 years of age), whether it is related to resting cerebral hemodynamics, and whether it recovers chronically.MethodsCerebral vasoreactivity and autoregulation, based on middle cerebral artery blood flow velocity, was assessed in 28 concussed participants (≤14 days of injury) and 29 matched controls. The participants in the concussion group returned for an 8‐week follow‐up assessment. Over the course of those 8‐weeks, participants recorded aerobic exercise frequency and duration.ResultsBetween groups, demographic, clinical, and hemodynamic variables were not significantly different. Vasoreactivity was significantly higher in the concussed group (p = 0.02). Within the concussed group, 60% of the variability in resting cerebral blood flow velocity was explained by vasoreactivity and two components of autoregulation – falling slope and effectiveness of autoregulation (adjusted R2 = 0.60, p < 0.001). Moreover, lower mean arterial pressure, lower responses to increases in arterial pressure, and lower vasoreactivity were significantly associated with larger symptom burden (adjusted R2 = 0.72, p < 0.01). By the 8‐week timepoint, symptom burden, but not vasoreactivity, improved in all but four concussed participants (p < 0.01). 8‐week change in vasoreactivity was positively associated with aerobic exercise volume (adjusted R2 = 0.19, p = 0.02).InterpretationConcussion resulted in changes in cerebrovascular regulatory mechanisms, which in turn explained the variability in resting cerebral blood flow velocity and acute symptom burden. Furthermore, these alterations persisted chronically despite symptom resolution, but was positively modified by aerobic exercise volume. These findings provide a mechanistic framework for further investigation into underlying cerebrovascular related symptomatology. ANN NEUROL 2021;90:43–51
Azobispyrazole Family as Photoswitches Combining (Near‐) Quantitative Bidirectional Isomerization and Widely Tunable Thermal Half‐Lives from Hours to Years**
Authors: He Yixin , Shangguan Zhichun , Zhang Zhao‐Yang , Xie Mingchen , Yu Chunyang , Li Tao 
Published: April 2021

AbstractAzobenzenes are classical molecular photoswitches that have been widely used. In recent endeavors of molecular design, replacing one or both phenyl rings with heteroaromatic rings has emerged as a strategy to expand molecular diversity and access improved photoswitching properties. Many mono‐heteroaryl azo molecules with unique structures and/or properties have been developed, but the potential of bis‐heteroaryl architectures is far from fully exploited. We report a family of azobispyrazoles, which combine (near‐)quantitative bidirectional photoconversion and widely tunable Z‐isomer thermal half‐lives from hours to years. The two five‐membered rings remarkably weaken the intramolecular steric hindrance, providing new possibilities for engineering the geometric and electronic structure of azo photoswitches. Azobispyrazoles generally exhibit twisted Z‐isomers that facilitate complete Z→E photoisomerization, and their thermal stability can be broadly adjusted regardless of the twisted shape, overcoming the conflict between photoconversion (favored by the twisted shape) and Z‐isomer stability (favored by the orthogonal shape) encountered by mono‐heteroaryl azo switches.
Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14**
Authors: Zhang Shuo , Sella Mauro , Sianturi Julinton , Priegue Patricia , Shen Dacheng , Seeberger Peter H. 
Published: April 2021

AbstractStreptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi‐synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.
Sub‐Second Time‐Resolved Surface‐Enhanced Raman Spectroscopy Reveals Dynamic CO Intermediates during Electrochemical CO2 Reduction on Copper
Authors: An Hongyu , Wu Longfei , Mandemaker Laurens D. B. , Yang Shuang , de Ruiter Jim , Wijten Jochem H. J. , Janssens Joris C. L. , Hartman Thomas , van der Stam Ward , Weckhuysen Bert M. 
Published: April 2021

AbstractThe electrocatalytic carbon dioxide (CO2) reduction reaction (CO2RR) into hydrocarbons is a promising approach for greenhouse gas mitigation, but many details of this dynamic reaction remain elusive. Here, time‐resolved surface‐enhanced Raman spectroscopy (TR‐SERS) is employed to successfully monitor the dynamics of CO2RR intermediates and Cu surfaces with sub‐second time resolution. Anodic treatment at 1.55 V vs. RHE and subsequent surface oxide reduction (below −0.4 V vs. RHE) induced roughening of the Cu electrode surface, which resulted in hotspots for TR‐SERS, enhanced time resolution (down to ≈0.7 s) and fourfold improved CO2RR efficiency toward ethylene. With TR‐SERS, the initial restructuring of the Cu surface was followed (<7 s), after which a stable surface surrounded by increased local alkalinity was formed. Our measurements revealed that a highly dynamic CO intermediate, with a characteristic vibration below 2060 cm−1, is related to C−C coupling and ethylene production (−0.9 V vs. RHE), whereas lower cathodic bias (−0.7 V vs. RHE) resulted in gaseous CO production from isolated and static CO surface species with a distinct vibration at 2092 cm−1.