bluuebunny/crossref_metadata_2025_split huggingface dataset:
The max‐p‐compact‐regions problem
Authors: Feng Xin , Rey Sergio , Wei Ran 
Published: November 2021

AbstractThe max‐p‐compact‐regions problem involves the aggregation of a set of small areas into an unknown maximum number (p) of compact, homogeneous, and spatially contiguous regions such that a regional attribute value is higher than a predefined threshold. The max‐p‐compact‐regions problem is an extension of the max‐p‐regions problem accounting for compactness. The max‐p‐regions model has been widely used to define study regions in many application cases since it allows users to specify criteria and then to identify a regionalization scheme. However, the max‐p‐regions model does not consider compactness even though compactness is usually a desirable goal in regionalization, implying ideal accessibility and apparent homogeneity. This article discusses how to integrate a compactness measure into the max‐p regionalization process by constructing a multiobjective optimization model that maximizes the number of regions while optimizing the compactness of identified regions. An efficient heuristic algorithm is developed to address the computational intensity of the max‐p‐compact‐regions problem so that it can be applied to large‐scale practical regionalization problems. This new algorithm will be implemented in the open‐source Python Spatial Analysis Library. One hypothetical and one practical application of the max‐p‐compact‐regions problem are introduced to demonstrate the effectiveness and efficiency of the proposed algorithm.
Instruments for the identification of patients in need of palliative care in the hospital setting: a systematic review of measurement properties
Authors: Teike Lüthi Fabienne , MacDonald Ibo , Rosselet Amoussou Joëlle , Bernard Mathieu , Borasio Gian Domenico , Ramelet Anne-Sylvie 
Published: November 2021

ABSTRACT

Objective:
The objective of this review was to provide a comprehensive overview of the measurement properties of the available instruments used by clinicians for identifying adults in need of general or specialized palliative care in hospital settings.

Introduction:
Identification of patients in need of palliative care has been recognized as an area where many health care professionals need guidance. Differentiating between patients who require general palliative care and patients with more complex conditions who need specialized palliative care is particularly challenging.

Inclusion criteria:
We included development and validation studies that reported on measurement properties (eg, content validity, reliability, or responsiveness) of instruments used by clinicians for identifying adult patients (>18 years and older) in need of palliative care in hospital settings.

Methods:
Studies published until March 2020 were searched in four databases: Embase.com, MEDLINE (Ovid), PubMed, and CINAHL (EBSCO). Unpublished studies were searched in Google Scholar, government websites, hospice websites, the Library Network of Western Switzerland, and WorldCat. The search was not restricted by language; however, only studies published in English or French were eligible for inclusion. The title and abstracts of the studies were screened by two independent reviewers against the inclusion criteria. Full-text studies were reviewed for inclusion by two independent reviewers. The quality of the measurement properties of all included studies were assessed independently by two reviewers according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology.

Results:
Out of the 23 instruments identified, four instruments were included, as reported in six studies: the Center to Advance Palliative Care (CAPC) criteria, the Necesidades Paliativas (NECPAL), the Palliative Care Screening Tool (PCST), and the Supportive and Palliative Care Indicators Tool (SPICT). The overall psychometric quality of all four instruments was insufficient according to the COSMIN criteria, with the main deficit being poor construct description during development.

Conclusions:
For the early identification of patients needing palliative care in hospital settings, there is poor quality and incomplete evidence according to the COSMIN criteria for the four available instruments. This review highlights the need for further development of the construct being measured. This may be done by conducting additional studies on these instruments or by developing a new instrument for the identification of patients in need of palliative care that addresses the current gaps in construct and structural validity.

Systematic review registration number:
PROSPERO CRD42020150074
Organ donation after medical assistance in dying: a scoping review protocol
Authors: Silva e Silva Vanessa , Ross-White Amanda , Hornby Laura , Lotherington Ken , Silva Amina , Rochon Andrea , Sarti Aimee , Dhanani Sonny 
Published: November 2021

ABSTRACT

Objective:
This scoping review will collate and summarize the current literature on what is known worldwide about organ donation following medical assistance in dying. The information gathered will be used to inform updates of current and future policies on organ donation following medical assistance in dying in Canada.

Introduction:
Medical assistance in dying is a controversial and contentious issue worldwide. While more countries are legalizing medical assistance in this regard, very few allow organ donation after such assistance has been given. At present, Canada, Belgium, and The Netherlands are the only three countries that permit this procedure. This scoping review will be conducted to summarize the current state of evidence and practices regarding organ donation following medical assistance in dying.

Inclusion criteria:
This review will consider articles and documents on individuals who choose organ donation following medical assistance in dying. Articles will be considered for inclusion if they explore organ donation following medical assistance in dying at home or in any health care setting in any country. Quantitative and qualitative studies, text and opinion papers, gray literature, and unpublished materials provided by researchers will be considered for inclusion.

Methods:
This review will be conducted in accordance with the JBI methodology for scoping reviews. Published and unpublished materials will be included. Databases will include MEDLINE, Embase, CINAHL, PsycINFO, Web of Science – Science Citation Index and Social Science Citation Index, and Academic Search Complete. Relevant gray literature and materials from organ donation organizations will be included. Two independent reviewers will screen all material, extract data, and complete the descriptive examination.
Screening of Lost Circulation Materials for Geothermal Applications: Experimental Study at High Temperature
Authors: Vivas Cesar , Salehi Saeed 
Published: November 2021

Abstract
This study presents a laboratory experimental research to determine the characteristics of lost circulation materials (LCMs) capable of addressing thermal degradation, providing bridging and sealing in geothermal conditions. Eleven different materials were tested: Walnut Fine, Walnut Medium, Sawdust, Altavert, Graphite Blend, Bentonite Chips, Micronized Cellulose (MICRO-C), Magma Fiber Fine, diatomaceous earth/amorphous silica powder (DEASP), Cotton Seed Hulls, and a Calcium Carbonate Blend. The filtration and sealing pressure of the LCMs were measured with HPHT equipment up to 149 °C (300 °F). Besides, the particle size distribution (PSD) of fine granular materials was measured. The results show that the performance of some LCM materials commonly used in geothermal operations is affected by high temperature. Characteristics such as shape and size made some materials more prone to thermal degradation. Also, it was found that the PSD of LCMs is a key factor in the effectiveness of bridging and sealing fractures. The results suggest that granular materials with a wide particle size distribution PSD are suitable for geothermal applications.
Multisensory Virtual Reality for Delivering Training Content to Machinery Operators
Authors: Bordegoni Monica , Carulli Marina , Spadoni Elena 
Published: November 2021

Abstract
The issue of training operators in the use of machinery is topical in the industrial field and in many other contexts, such as university laboratories. Training is about learning how to use machinery properly and safely. Beyond the possibility of studying manuals to learn how to use a machine, operators typically learn through on-the-job training. Indeed, learning by doing is in general more effective, tasks done practically are remembered more easily, and the training is more motivating and less tiresome. On the other hand, this training method has several negative factors. In particular, safety may be a major issue in some training situations. An approach that may contribute overcoming negative factors is using Virtual Reality and digital simulation techniques for operators training. The research work presented in this paper concerns the development of a multisensory virtual reality application for training operators to properly use machinery and personal protective equipment (PPE). The context selected for the study is a university laboratory hosting manufacturing machinery. The application allows user to navigate the laboratory, to approach a machine and learn about how to operate it, and also to use proper PPE while operating a machine. Specifically, the paper describes the design and implementation of the application and presents the results of preliminary testing sessions.
Variation of Lubricant Distribution Across the Radial Direction in a Journal Bearing
Authors: Wei Shanshan , Kligerman Yuri , Goltsberg Roman , Etsion Izhak 
Published: November 2021

AbstractA computational fluid dynamics analysis of two-phase flow was used to obtain the distribution of lubricant in a journal bearing, including inlet tube and groove. It was found that for an incomplete starting film, the oil spread-length varies along the groove depth and film thickness. The magnitude of variation was found to be independent of the inlet mass flowrate. Numerical simulations of the proposed model show that in the cavitation region, the streamlets do not fill the entire film thickness. The present numerical model agrees with experimental observations.
International Swimming League: Do Successive Events Lead to Improve Swimming Performance?
Authors: Pla Robin , Leroy Arthur , Raineteau Yannis , Hellard Philippe 
Published: November 2021

Purpose: To quantify the impact of successive competitions on swimming performance in world-class swimmers. Methods: An entire data set of all events swum during a new competition named the International Swimming League was collected. A Bayesian linear mixed model has been proposed to evaluate whether a progression could be observed during the International Swimming League’s successive competitions and to quantify this effect according to event, age, and gender. Results: An overall progression of 0.0005 (0.0001 to 0.0010) m/s/d was observed. The daily mean progression (ie, faster performance) was twice as high for men as for women (0.0008 [0.00 to 0.0014] vs 0.0003 [−0.0003 to 0.0009] m·s−1). A tendency toward higher progression for middle distances (200 and 400 m) and for swimmers of a higher caliber (above 850 FINA [Fédération Internationale de Natation] points) was also observed. Swimmers between 23 and 26 years of age seemed to improve their swimming speed more in comparison with the other swimmers. Conclusions: This new league format, which involves several competitions in a row, seems to allow for an enhancement in swimming performance. Coaches and their support staff can now adapt their periodization plan in order to promote competition participation.
Beating Adolescent Self-Harm (BASH): a randomised controlled trial comparing usual care versus usual care plus a smartphone self-harm prevention app (BlueIce) in young adolescents aged 12–17 who self-harm: study protocol
Authors: Greenhalgh Isobel , Tingley Jessica , Taylor Gordon , Medina-Lara Antonieta , Rhodes Shelley , Stallard P 
Published: November 2021

IntroductionA mobile app, BlueIce, was codesigned with young people with a history of self-harm to provide them with more accessible and available evidence-based support at times of distress. A preliminary evaluation found that BlueIce was acceptable, safe and used by young people and helped to reduce self-harm. The present study is designed to assess the effectiveness and cost-effectiveness of adding BlueIce to usual Child and Adolescent Mental Health Service (CAMHS).Methods and analysisThis study is a single-blind, randomised controlled trial comparing usual CAMHS care with usual care plus BlueIce. A total of 138 adolescents aged 12–17 with current or a history of self-harm will be recruited through the Oxford Health National Health Service (NHS) Foundation Trust via their CAMHS clinician. The primary outcome is self-harm at 12 weeks assessed using the Risk Taking and Self-Harm Inventory for Adolescents. Secondary outcomes include mood, anxiety, hopelessness, general behaviour, sleep and impact on everyday life at 12 weeks and 6 months. Health-related quality of life and healthcare resource utilisation data will be collected at baseline, 12 weeks and 6 months. Postuse interviews at 12 weeks will determine the acceptability, safety and usability of BlueIce.Ethics and disseminationThe study was approved by the NHS South Central—Oxford B NHS Research Ethics Committee (19/SC/0212) and by the Health Research Authority (HRA) and Health and Care Research Wales. Findings will be disseminated in peer review open-access journals and at academic conferences.Trial registration numberISRCTN10541045.
Nordic study on human milk fortification in extremely preterm infants: a randomised controlled trial—the N-forte trial
Authors: Jensen Georg Bach , Ahlsson Fredrik , Domellöf Magnus , Elfvin Anders , Naver Lars , Abrahamsson Thomas 
Published: November 2021

IntroductionThe mortality rate of extremely low gestational age (ELGA) (born <gestational week 28+0) infants remains high, and severe infections and necrotising enterocolitis (NEC) are common causes of death. Preterm infants receiving human milk have lower incidence of sepsis and NEC than those fed a bovine milk-based preterm formula. Despite this, fully human milk fed ELGA infants most often have a significant intake of cow’s milk protein from bovine-based protein fortifier. The aim of this study is to evaluate whether the supplementation of human milk-based, as compared with bovine-based, nutrient fortifier reduces the prevalence of NEC, sepsis and mortality in ELGA infants exclusively fed with human milk.Methods and analysisA randomised-controlled multicentre trial comparing the effect of a human breast milk-based fortifier with a standard bovine protein-based fortifier in 222–322 ELGA infants fed human breast milk (mother’s own milk and/or donor milk). The infants will be randomised to either fortifier before reaching 100 mL/kg/day in oral feeds. The intervention, stratified by centre, will continue until the target postmenstrual week 34+0. The primary outcome is a composite of NEC, sepsis or death. Infants are characterised with comprehensive clinical and nutritional data collected prospectively from birth until hospital discharge. Stool, urine, blood and breast milk samples are collected for analyses in order to study underlying mechanisms. A follow-up focusing on neurological development and growth will be performed at 2 and 5.5 years of age. Health economic analyses will be made.Ethics and disseminationThe study is conducted according to ICH/GCP guidelines and is approved by the regional ethical review board in Linköping Sweden (Dnr 2018/193-31, Dnr 2018/384-32). Results will be presented at scientific meetings and published in peer-reviewed publications.Trial registration numberThe study was registered with ClinicalTrials.govNCT03797157, 9 January 2019.
Outcome and right ventricle remodelling after valve replacement for pulmonic stenosis
Authors: Laflamme Emilie , Wald Rachel M , Roche S Lucy , Silversides Candice K , Thorne Sara A , Colman Jack M , Benson Lee , Osten Mark , Horlick Eric , Oechslin Erwin , Alonso-Gonzalez Rafael 
Published: November 2021

BackgroundComplications and need for reinterventions are frequent in patients with pulmonary valve stenosis (PVS). Pulmonary regurgitation is common, but no data are available on outcome after pulmonary valve replacement (PVR).MethodsWe performed a retrospective analysis of 215 patients with PVS who underwent surgical valvotomy or balloon valvuloplasty. Incidence and predictors of reinterventions and complications were identified. Right ventricle (RV) remodelling after PVR was also assessed.ResultsAfter a median follow-up of 38.6 (30.9–49.4) years, 93% of the patients were asymptomatic. Thirty-nine patients (18%) had at least one PVR. Associated right ventricular outflow tract (RVOT) intervention and the presence of an associated defect were independent predictors of reintervention (OR: 4.1 (95% CI 1.5 to 10.8) and OR: 3.6 (95% CI 1.9 to 6.9), respectively). Cardiovascular death occurred in 2 patients, and 29 patients (14%) had supraventricular arrhythmia. Older age at the time of first intervention and the presence of an associated defect were independent predictors of complications (OR: 1.0 (95% CI 1.0 to 1.1) and OR: 2.1 (95% CI 1.1 to 4.2), respectively). In 16 patients, cardiac magnetic resonance before and after PVR was available. The optimal cut-off values for RV volume normalisation were 193 mL/m2for RV end-diastolic volume indexed(sensitivity 80%, specificity 64%) and 100 mL/m2for RV end-systolic volume indexed(sensitivity 80%, specificity 56%).ConclusionsPrevious RVOT intervention, presence of an associated defect and older age at the time of first repair were predictors of outcome. More data are needed to guide timing of PVR, and extrapolation of tetralogy of Fallot guidelines to this population is unlikely to be appropriate.
Cardiac stereotactic ablative radiotherapy for control of refractory ventricular tachycardia: initial UK multicentre experience
Authors: Lee Justin , Bates Matthew , Shepherd Ewen , Riley Stephen , Henshaw Michael , Metherall Peter , Daniel Jim , Blower Alison , Scoones David , Wilkinson Michele , Richmond Neil , Robinson Clifford , Cuculich Phillip , Hugo Geoffrey , Seller Neil , McStay Ruth , Child Nicholas , Thornley Andrew , Kelland Nicholas , Atherton Philip , Peedell Clive , Hatton Matthew 
Published: November 2021

BackgroundOptions for patients with ventricular tachycardia (VT) refractory to antiarrhythmic drugs and/or catheter ablation remain limited. Stereotactic radiotherapy has been described as a novel treatment option.MethodsSeven patients with recurrent refractory VT, deemed high risk for either first time or redo invasive catheter ablation, were treated across three UK centres with non-invasive cardiac stereotactic ablative radiotherapy (SABR). Prior catheter ablation data and non-invasive mapping were combined with cross-sectional imaging to generate radiotherapy plans with aim to deliver a single 25 Gy treatment. Shared planning and treatment guidelines and prospective peer review were used.ResultsAcute suppression of VT was seen in all seven patients. For five patients with at least 6 months follow-up, overall reduction in VT burden was 85%. No high-grade radiotherapy treatment-related side effects were documented. Three deaths (two early, one late) occurred due to heart failure.ConclusionsCardiac SABR showed reasonable VT suppression in a high-risk population where conventional treatment had failed.
Efficacy and safety of colchicine in COVID-19: a meta-analysis of randomised controlled trials
Authors: Mehta Kedar Gautambhai , Patel Tejas , Chavda Paragkumar D , Patel Parvati 
Published: November 2021

BackgroundColchicine, an anti-inflammatory drug is prescribed nowadays for COVID-19. In this meta-analysis, we evaluated efficacy and safety of colchicine in patients with COVID-19.MethodsWe searched databases for randomised controlled studies evaluating efficacy and/or safety of colchicine as compared with supportive care in patients with COVID-19. The efficacy outcomes were mortality, ventilatory support, intensive care unit (ICU) admission and length of hospital stay. The safety outcomes were adverse events, serious adverse events and diarrhoea. A meta-analytical summary was estimated using random effects model through Mantle-Hanzle method. An I2 test was used to assess heterogeneity. The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach was used to assess quality of evidence for each outcome.ResultsOut of 69 full texts assessed, 6 studies (16148 patients with COVID-19) were included in meta-analysis. Patients receiving colchicine did not show significant reduction in mortality (risk difference, RD −0.00 (95% CI −0.01 to 0.01), I2=15%), ventilatory support (risk ratio, RR 0.67 (95% CI 0.38 to 1.21), I2=47%), ICU admission (RR 0.49 (95% CI 0.19 to 1.25), I2=34%), length of hospital stay (mean difference: −1.17 (95% CI −3.02 to 0.67), I2=77%) and serious adverse events (RD −0.01 (95% CI −0.02 to 0.00), I2=28%) than those who received supportive care only. Patients receiving colchicine had higher rates of adverse events (RR 1.58 (95% CI 1.07 to 2.33), I2=81%) and diarrhoea (RR 1.93 (95% CI 1.62 to 2.29), I2=0%) than supportive care treated patients. The GRADE quality of evidence was moderate for most outcomes.ConclusionThe moderate quality evidence suggests no benefit of addition of colchicine to the standard care regimen in patients with COVID-19.
Thrust measurement and thrust balance development at DLR’s electric propulsion test facility
Authors: Neumann Andreas , Simon Jens , Schmidt Jens 
Published: November 2021

AbstractElectric space propulsion thrusters only produce low thrust forces. For the fulfillment of a space mission this implies long thruster runtimes, and this entails long qualification times on ground. For such long testing times, a ground facility requires a vacuum chamber and a powerful pumping system which can guarantee high vacuum over extended times and under thruster gas load. DLR’s STG-ET is such a ground test facility. It has a high pumping capability for the noble gases typically used as propellants. One basic diagnostic tool is a thrust measurement device, among various other diagnostic systems required for electric propulsion testing, e.g. beam diagnostics. At DLR we operate a thrust balance developed by the company AST with a thrust measurement range of 250 mN and capable of thruster weights up to 40 kg. Adversely, it is a bulky and heavy device and all upgrades and qualification work needs to be done in a large vacuum chamber. In order to have a smaller device at hand a second thrust stand is under development at DLR. The idea is to have a light and compact balance that could also be placed in one of the smaller DLR vacuum chambers. Furthermore, the calibration is more robust and the whole device is equipped with a watercooled housing. First tests are promising and showed a resolution well below 1 mN. In this paper we give background information about the chamber, describe the basics of thrust measurement and the development of a new balance.