bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating long non-coding RNA signature in knee osteoarthritis patients with postoperative pain one-year after total knee replacement
Authors: Giordano Rocco , Petersen Kristian Kjær , Santoro Massimo , Pazzaglia Costanza , Simonsen Ole , Valeriani Massimiliano , Arendt-Nielsen Lars 
Published: July 2021

Abstract

Objectives
The incidence of chronic postoperative pain after total knee replacement (TKR) is approx. 20%, and hence preoperative risk factors are important to identify. Recent studies have indicated that preoperative inflammatory markers might hold prognostic information for the development of chronic postoperative pain. Long non-coding RNA (lncRNA) regulates the expression of genes related to e.g. inflammatory processes. The current study aimed to investigate the preoperative lncRNA signature as possible preoperative predictive markers for chronic postoperative pain following TKR.

Methods
Serum samples, collected preoperatively from 20 knee osteoarthritis (KOA) patients, were analyzed for 84 validated circulatory lncRNA. Pain intensity was assessed using a visual analog scale (VAS) before and one-year after TKR. Differences for the lncRNA expression were analyzed between patients with chronic postoperative pain (VAS≥3) and those with a normal postoperative recovery (VAS<3).

Results
LncRNA Myeloid Zinc Finger 1 Antisense RNA 1 (MZF1-AS1) (fold change −3.99; p-value: 0.038) (shown to be involved neuropathic pain) Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) (fold change −3.39; p-value: 0.044) (shown to be involved neuropathic pain); Patched 1 pseudogene (LOC100287846) (fold change −6.99; p-value: 0.029) (unknown in pain) were down-regulated preoperatively in the group with chronic postoperative pain compared to the group normal postoperative pain recovery.

Conclusions
These findings suggest, that TKR patients with chronic postoperative pain present preoperative downregulations of three specific lncRNA detectable at the systemic level. The presented study might give new insights into the complexity of chronic postoperative pain development and show how non-coding RNA plays a role in the underlying molecular mechanisms of pain.
The Effect of a Chemical Warm Mix Additive on the Self-Healing Capability of Bitumen
Authors: Aurilio Roberto M. , Aurilio Mike , Baaj Hassan 
Published: July 2021

Abstract
Warm mix asphalt (WMA) technologies reduce the production temperature of hot mix asphalt allowing for mixing and paving at lower temperatures. As a result, the use of WMAs reduces emissions and allows for longer transport times. Because of the recent increase of chemical warm mix additives in industry, the effect of a chemical warm mix additive (cWMA) on the intrinsic self-healing ability of the bitumen was investigated. Bitumen specimens containing three concentrations of cWMA were evaluated at four aging levels (unaged, rolling thin film oven [RTFO]-163°C, RTFO-130°C, and RTFO+ pressure aging vessel [PAV] aged) using the simplified–linear amplitude sweep healing (SLASH) (linear amplitude sweep with a single rest period fatigue-healing) test. Results indicate that oxidative aging of bitumen is reduced with increasing cWMA concentration but may be more heavily influenced by the aging temperature. It was also observed that RTFO+PAV-aged bitumen samples demonstrate greater fatigue restoration ability compared to RTFO and unaged binders. Supplementary work using video-based analysis of dynamic shear rheometer samples revealed that issues may arise from the calibration of the cohesive failure damage level as described in the original LASH procedure because of significant changes in sample geometry observed during the amplitude sweeps for unaged and RTFO-aged material. These results demonstrate that LAS-based healing tests warrant further research to optimize loading and rest period parameters for a wider range of bituminous materials.
ESTUDIOS ARQUEOLÓGICOS EN LOS VALLES DE ICA, PISCO, CHINCHA Y CAÑETE
Authors: Menzel Dorothy 
Published: July 2021

El énfasis principal del Informe que se presenta a continuación, está en la identificación de los estilos de cerámica y de sus relaciones cronológicas de los patrones culturales que a su vez integran el estudio de la arqueología. Por eso, el problema no solo consiste en la observación y documentación de las relaciones estilísticas sino también en determinar con la mayor exactitud posible la secuencia cronológica de los estilos de una zona y la correlación cronológica, que existe entre la sucesión de estilos en diferentes áreas. Puesto que la semejanza estilística no significa siempre contemporaneidad y desde que, por otro lado, existen a un mismo tiempo tradiciones de estilo completamente distintas, es necesario tratar las relaciones de tiempo que hay entre los estilos, conforme a unidades fijas de tiempo, que no contienen, referencias de carácter estilístico. Como no existe tampoco, ninguna técnica que permita fijar el año exacto la fecha correspondiente a la mayor parte de los restos materiales, es preciso emplear una escala relativa de tiempo adjudicada a una región para que sirva como punto fundamental de referencia al tratar sobre la contemporaneidad o diferencias de tiempo entre los diversos estilos. NOTA:El trabajo que se publica a continuación es uno de los informes del Programa que preparó la Comisión Fulbright de Intercambio Educativo en coordinación con el Instituto de Etnología y Arqueología de la Universidad de San Marcos, entre 1957 y 1960. En números anteriores de este Boletín, publicamos algunos de los informes preliminares presentados por otros arqueólogos; este es el primer informe de conjunto que se publica y aún cuando fue escrito hace ya varios años y muchos de los puntos que toca han sido superados por investigaciones posteriores, aún de la propia autora, sin embargo, hay mucho material inédito sobre la Costa Sur, que será de gran utilidad para los investigadores.La sección correspondiente la seriación de la cerámica Paracas ha sido revisada íntegramente en un libro escrito por Dorothy Menzel, John Rowe y Lawrence Dawson, publicado en 1964 por la Universidad de California (Berkeley) en su serie: University of California Publications in American Archaeology and Ethnology (vol. 50). El libro se intitula The Paracas Pottery of Ica A Study in Style and Time. Algunos trabajos adicionales de los arqueólogos de Berkeley, han refinado las series de Nasca y de Ica, pero en todos los casos, los cambios no son muy grandes y en ningún caso se ha publicado una visión de conjunto como la que recién hoy podemos presentar.
Hemoptysis in Renal Transplant Recipients
Authors: Georgakopoulou Vasiliki Epameinondas , Gkoufa Aikaterini , Aravantinou Aikaterini , Garmpis Nikolaos , Mantzouranis Konstantinos , Chlapoutakis Serafeim , Sklapani Pagona , Garmpi Anna , Trakas Nikolaos , Damaskos Christos 
Published: July 2021

Background: Hemoptysis is the expectoration of blood from respiratory system. Clinical entities associated with hemoptysis in renal transplant recipients differ from those causing hemoptysis in common population. This review summarizes all reported clinical conditions related to hemoptysis in renal transplant patients, their causes, diagnostic approach and management.Methods and Materials: Primary literature was researched through MEDLINE/PubMed database and Google Scholar without restrictions. Relevant and current literatures related to hemoptysis in renal transplant recipients were used.Results: Overall 23 articles were included, since they report clinical conditions associated with hemoptysis in renal transplant recipients. Opportunistic lung infections, pulmonary hemorrhage associated with drugs and malignancies are usual causes of hemoptysis in these patients, sometimes with a fatal outcome.Conclusions: Hemoptysis is an important manifestation in renal transplant patients, caused frequently by rare clinical entities, different from those in common population.
Pregnancy and deep brain stimulation therapy for epilepsy
Authors: Bóné Beáta , Kovács Norbert , Balás István , Horváth Réka A. , Dóczi Tamás , Janszky József 
Published: July 2021

AbstractObjective: Neuromodulation therapy ‐vagus nerve stimulation (VNS) and deep brain stimulation (DBS)‐ is one of the therapeutic options for drug‐resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue whether DBS is safe in pregnancy. We report here two women with epilepsy who gave birth to healthy children with DBS therapy.Methods: We describe two cases, a 30‐year‐old woman and a 37‐year‐old woman. Both were implanted with DBS due to drug‐resistant epilepsy.Results: Both of our patients showed a significant improvement after DBS implantation and thereafter gave birth to a healthy child with DBS treatment. The severity and frequency of epileptic seizures did not change during pregnancy and after childbirth. Although a Caesarean section was performed in one case, pregnancies and births were essentially problem‐free. At present, the two‐ and four‐year‐old children are healthy.Significance: Considering these cases, previously described VNS cases, and DBS cases with non‐epileptic indications; we suggest that pregnancy and childbirth are safe in epilepsy patients with DBS, moreover, DBS treatment has probably no effect on foetal abnormalities or breastfeeding.
Effect of fixed orthodontic treatment on mandibular condyle bone quality in different malocclusion groups
Authors: YÜZBAŞIOĞLU ERTUĞRUL Betül 
Published: July 2021

Purpose: The aim of this study was to investigate the effects of orthodontic treatment on the mandibular condyle head bone formation according to different orthodontic malocclusion groups.
Materials and Methods: In the study, forty-eight patients were examined. Individuals included in the study were grouped according to malocclusion groups. Our study was carried out retrospectively. The quality of mandibular condyle bone in panoramic images of patients before and after orthodontic treatment were compared retrospectively. This examination was carried out by a fractal analysis method.
Results: According to the findings we obtained from our study; the change in mandibular condyle bone quality before and after orthodontic treatment by age and gender was not found to be statistically different. After orthodontic treatment in individuals with Class I and III malocclusions, the trabecular density structure of the mandibular condyle bone increased and decreased in individuals with Class II malocclusion. The change in mandibular condyle bone quality before and after orthodontic treatment by malocclusion groups was found to be statistically different.
Conclusion: The fractal analysis method is a technique that facilitates the diagnosis of minimal changes occurring on the radiographs of orthodontic treatment patients and to evaluate the prognosis of the disease. A relationship was found between orthodontic treatment applied to different malocclusion groups and mandibular condyle head bone formation. When evaluating orthodontic treatments, mandibular condyle head bone formation should be taken into consideration.
Human cytomegalovirus infection, viraemia and retinitis among people living with HIV/AIDS in Kano, North-Western Nigeria
Authors: Edwin Chinagozi P. , Hassan Sadiq , Ebisike Philips I. , Habib Saudat G. , Amole Taiwo G. , Bakare Rasheed A. 
Published: July 2021

Background: Human cytomegalovirus (HCMV) is a leading cause of opportunistic infection in HIV-infected patients. HCMV viraemia is an active infection marker and prelude to end-organ diseases (EODs), such as retinitis. The aim of the study was to assess the burden and associated factors of HCMV infection, viraemia and retinitis among HIV-infected patients in Nigeria.Methods: Comparative cross-sectional study of 160 HIV-infected adults, comprising 80 participants in each of <100/mm3 and ≥100 cells/mm3 CD4+ cell count groups, who attended HIV clinic at a tertiary hospital located in a major Nigerian city. A questionnaire was used to collect data from eligible consenting participants and their case files. Sera from all participants were tested for anti-HCMV IgG using ELISA method, and plasma of seropositive participants were subjected to PCR for HCMV viraemia. Participants whose samples were HCMV viraemic were examined for HCMV retinitis using indirect ophthalmoscopy. Data was analyzed using Minitab vs 14.1.1PP.Results: All 160 participants tested positive for anti-HCMV IgG. HCMV viraemia was 14.4% (23 of 160) generally, but comparatively more among <100 CD4 cells/mm3 group (18.8%; 15 of 80) than in ≥100 cells/mm3 patient group (10%; 8 of 80). Only HCMV viraemic patients in <100 CD4 cells/mm3 group (20%; 3 of 15) were diagnosed with HCMV retinitis. WHO stage was associated with HCMV viraemia (χ2= 7.79, p=0.05) and HCMV retinitis (χ2= 4.60, p=0.03). The only predictor of HCMV retinitis was WHO staging I and II [aOR = 0.04, 95%CI (0.01- 0.52)]. Conclusions: Evidence of previous and active HCMV infection is prevalent among PLWHA in Nigeria with WHO staging being associated and a predictor of HCMV viraemia and retinitis, respectively.
Application of rubber band ligation as a treatment of internal hemorrhoids
Authors: Sari Sevil Ozer , Yıldız Coşkun 
Published: July 2021

Background: Aim was to more than three-quarters of the whole population will experience complaints of hemorrhoids at some point in their lifetime. The treatment of internal hemorrhoids includes medical, minimally invasive and surgical treatments. The aim of the study was to evaluate the data of patients who were applied with rubber band ligation (RBL) as a minimally invasive treatment method of internal hemorrhoids.Method: The study conducted in the gastroenterology department of Izmir Tepecik training and research hospital between December 2015 and December 2019. Demographic and laboratory data of the patients, the success and the complications rates of the procedure were evaluated retrospectively .Results: Evaluation was carried out in 45 consecutive patients, comprising 23 (51.1%) females and 22 (48.9%) males with a mean age of 54.62±7.82 years (range, 40-82 years). Procedural success rate was 91.1% and failure of treatment was seen in 8.9% of the patient. Recurrence rate of RBL procedure determined with control rectoscopy was found as 5.26% at 1 year follow-up. No major complications developed in any patient. Significant correlation was determined between the development of bleeding and the use of anticoagulants and anti-aggregants (p=0.003). No significant relationship was seen between the number of band ligation procedures and the development of complications (p=0.275).Conclusions: The application of RBL, which is widely used in the treatment of internal hemorrhoids, is a reliable and low-cost method that shortens the length of stay in hospital, which can be preferred in patients with high comorbidity risk for surgery.
KOMPLIKASI KEHAMILAN DAN PERSALINAN PADA KEHAMILAN REMAJA
Authors: Husna Faqihati , Aldika Akbar Muhammad Ilham , Amalia Rize Budi 
Published: July 2021

AbstrakLatar Belakang: Menurut UNICEF, setiap lima kelahiran bayi terdapat satu bayi lahir dari ibu dengan usia dibawah 19 tahun. Kehamilan pada remaja usia 15-19 tahun di negara berkembang mencapai angka 21 juta. Kehamilan remaja merupkan masalah yang tersebar di seluruh dunia dan berdampak terhadap kesehatan ibu dan anak. (Mukhopadhyay, 2010), secara luas kematian yang disebabkan oleh kehamilan merupakan penyebab utama kematian anak perempuan usia 15-19 tahun (WHO, 2017). Remaja memiliki risiko komplikasi kehamilan yang tinggi, salah satunya adalah persalinan prematur, IUGR dan pre-eklamsia. (Baker, 2007).Terjadi peningkatan risiko komplikasi sebesar 2 kali lipat pada kehamilan remaja dibandingkan kehamilan pada wanita usia 20-an (Utomo I. D., 2013), Penelitian ini bertujuan untuk mencari hubungan kehamilan remaja dengan komplikasi kehamilan dan persalinan. Metode: Penelitian ini menggunakan metode analitik observasional dengan pendekatan retrospektif cross sectional dengan jumlah sampel 40 dan diambil dengan teknik cosecutive sampling. Hasil: Komplikasi pada kehamilan remaja mencapai 60%. Hasil analisis hubungan kehamilan remaja dengan komplikasi kehamilan (p value= 0,0100 OR = 6), anemia ( p value 0,013 OR=7,364), defisiensi gizi p value=0,400), prekalmisa/eklamsia (p value =0,300), komplikasi persalinan (p value =1,000), persalinan SC (p value=1,000) dan KPD (p value =1,000). Kesimpulan: Pada penelitian ini kehamilan remaja berpengaruh pada komplikasi kehamilan dengan penyulit dominan anemia dan tidak berpengaruh pada komplikasi persalinan.AbstractBackgrounds: According to UNICEF, every five babies born there is one baby born to a mother under the age of 19 years. Pregnancy in adolescents aged 15-19 years in developing countries reaches 21 million. Teenage pregnancy was a problem that spread throughout the world and had an impact on maternal and child health. (Mukhopadhyay, 2010), widely deaths caused by pregnancy are the main cause of death for girls aged 15-19 years (WHO, 2017). Adolescents had a high risk of pregnancy complications, one of which is premature labor, IUGR and pre-eclampsia. (Baker, 2007). There has been a 2-fold increase in the risk of complications in adolescent pregnancies versus pregnancies in women in their 20s (Utomo I. D., 2013). Methods: This study were observational analytic method with a retrospective cross sectional approach with 40 samples and was taken by cosecutive sampling technique. Results: Complications in adolescent pregnancy reach 60%. The results of the analysis of the relationship of adolescent pregnancies with complications of pregnancy showed (p value= 0,0100 OR = 6), anemia ( p value 0,013 OR=7,364), nutritional deficiency (p value=0,400), preeclampsia/eclampsia (p value =0,300), labor complications (p value =1,000), sectio caesaria (p value=1,000) dan premature rupture of membrane (p value =1,000)
STATUS GIZI DAN USIA MENARCHE SEBAGAI FAKTOR RISIKO DISMENOREA PADA REMAJA PUTRI SMAN 19 SURABAYA
Authors: Kosim Rim , Hardianto Gatut , Kasiati Kasiati 
Published: July 2021

Abstrak Latar belakang: Dismenorea merupakan gangguan menstruasi berupa nyeri perut bawah sesaat atau bersamaan dengan permulaan menstruasi. Menstruasi merupakan kejadian fisiologis dalam tubuh wanita dan dapat disertai beberapa gangguan salah satunya dismenorea. Kejadian dismenorea bagi remaja dapat mengganggu aktivitas sehari-hari termasuk sekolah. Di Indonesia dari hasil penelitian PIK-KRR kejadian dismenorea pada remaja putri sebesar 72,89%. Faktor-faktor yang terkait dismenorea meliputi usia dibawah 20 tahun, status gizi, usia menarche, riwayat keluarga dengan dismenorea, dan merokok. Penelitian ini bertujuan menganalisis hubungan status gizi dan usia menarche dengan kejadian dismenorea. Metode: Menggunakan metode analitik observasional dengan rancangan penelitian cross sectional. Sampel yang digunakan yaitu sebanyak 100 responden dengan tehnik simple random sampling. Pengumpulan data berupa data primer dari responden. Analisis data menggunakan uji chi square. Hasil: Terdapat hubungan antara status gizi dan usia menarche dengan kejadian dismenorea pada remaja putri SMAN 19 Surabaya (uji chi square status gizi dengan kejadian dismenorea p value = 0,023 serta usia menarche dengan kejadian dismenorea p value = 0,047). Kesimpulan: Status gizi dan usia menarche merupakan faktor risiko yang memiliki hubungan bermakna dengan kejadian dismenorea pada remaja putri.Abstract Introduction: Dysmenorrhea is a menstrual disorder in the form of lower abdominal pain before or right with the onset of menstruation. Menstruation is a physiological event in a woman's body and can be accompanied by several disorders, one of which is dysmenorrhoea. The incidence of dysmenorrhea for adolescents can disrupt daily activities including school. In Indonesia, the results of PIK-KRR’s study shows the incidence of dysmenorrhoea in young women was 72.89%. Factors related to dysmenorrhea including age under 20 years, nutritional status, age of menarche, family history of dysmenorrhea, and smoking. This study aims to analyze the relationship between nutritional status and age of menarche with the incidence of dysmenorrhea. Method: This study used an observational analytic method with a cross sectional study design. The sample used is 100 respondents using simple random sampling method. Data is collected in the form of primary data from respondents. Data analysis used the chi square test. Result: There is a relationship between nutritional status and age of menarche with the incidence of dysmenorrhea in female adolescents of SMAN 19 Surabaya (chi square test of nutritional status with incidence of dysmenorrhoea p = 0.023 and age of menarche with incidence of dysmenorrhea p = 0.047). Conclusion: Nutritional status and age of menarche are risk factors that have a significant relationship with the incidence of dysmenorrhea in female adolescents.
HUBUNGAN PENGETAHUAN, SIKAP, KUALITAS KIE, DAN DUKUNGAN SUAMI TERHADAP TINGKAT KONSUMSI VITAMIN A PADA IBU NIFAS
Authors: Riskitasari Aulia , Kasiati Kasiati , Fatmaningrum Widati 
Published: July 2021

Abstrak Latar Belakang: Masa nifas merupakan masa yang terjadi setelah persalinan yang berlangsung antara 1 jam setelah lahirnya plasenta sampai dengan 42 hari setelah melahirkan. Seorang wanita membutuhkan perawatan pasca salin untuk deteksi dini dan penannganan komplikasi, kebutuhan mobilisasi, nutrisi, personal hygiene dan kebutuhan penunjang lainnya. Metode: Penelitian ini menggunakan observasional analitik dengan teknik purposive sampling dengan memberikan beberapa pertanyaan melalui kuesioner pada 102 responden ibu yang sudah melewati masa nifas. Hasil: hasil uji chi square- contingency coefficient didapatkan hasil bahwa pengetahuan (p= 0,293) tidak ada hubungan, sikap (p= 0,922) tidak ada hubungan, kualitas KIE (p= 0,000) ada hubungan dan dukungan suami (p= 0,001) ada hubungan. Kesimpulan: Tingkat pengetahuan dan sikap seorang ibu tidak ada hubungan dengan tingkat konsumsi vitamin A pada masa nifas sedangkan kualitas KIE dan dukungan suami yang didapatkan ibu selama masa kehamilan, persalinan dan nifas ada hubungan terhadap tingkat konsumsi vitamin A pada ibu di masa nifas.Abstract Background: Postpartum period is a period that occurs after labor that lasts between 1 hour after the birth of the placenta up to 42 days after delivery. A woman needs postpartum care for early detection and management of complications, mobilization needs, nutrition, personal hygiene and other support needs. Method: This study used observational analytic with purposive sampling technique by giving several questions through questionnaires to 102 respondents of mothers who had passed the postpartum period. Results: the results of the chi square-coefficient contingency test showed that knowledge (p = 0.293) had no relationship, attitude (p = 0.922) had no relationship, KIE quality (p = 0,000) there was a relationship and husband's support (p = 0.001) relationship. Conclusion: The level of knowledge and attitudes of a mother has no relationship with level consumption of vitamin A during the puerperium while the KIE quality and husband's support obtained by the mother during pregnancy, childbirth and postpartum are related to level consumption of vitamin A in the mother during childbirth.