bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poziotinib for Patients With HER2 Exon 20 Mutant Non–Small-Cell Lung Cancer: Results From a Phase II Trial
Authors: Elamin Yasir Y. , Robichaux Jacqulyne P. , Carter Brett W. , Altan Mehmet , Gibbons Don L. , Fossella Frank V. , Lam Vincent K. , Patel Anisha B. , Negrao Marcelo V. , Le Xiuning , Mott Frank E. , Zhang Jianjun , Feng Lei , Blumenschein George , Tsao Anne S. , Heymach John V. 
Published: September 2021

PURPOSE Targeted therapies against non–small-cell lung cancer (NSCLC) harboring HER2 mutations remain an unmet need. In this study, we assessed the efficacy and safety of poziotinib in patients with HER2 exon 20 mutant advanced NSCLC in a single-arm, open-label, phase II study. PATIENTS AND METHODS Patients with advanced HER2 exon 20 mutant NSCLC were enrolled to receive poziotinib at a dose of 16 mg/d for 28-day cycles. The primary end point was objective response rate per RECIST version 1.1. Confirmatory scans were performed at least 28 days from initial radiologic response. RESULTS Thirty patients received poziotinib treatment. At baseline, 90% of patients received prior platinum-based chemotherapy and 53% had two lines or more prior systemic therapies. As of data cutoff on March 1, 2021, the confirmed objective response rate was 27% (95% CI, 12 to 46). Responses were observed across HER2 exon 20 mutation subtypes. The median duration of response was 5.0 months (95% CI, 4.0 to not estimable). The median progression-free survival was 5.5 months (95% CI, 4.0 to 7.0). The median overall survival was 15 months (95% CI, 9.0 to not estimable). The most common grade 3 treatment-related adverse events were skin rash (47%) and diarrhea (20%). There was one possible treatment-related death because of pneumonitis. CONCLUSION Poziotinib showed promising antitumor activity in patients with HER2 exon 20 mutant NSCLC including patients who had previously received platinum-based chemotherapy.
Socioeconomic and Racial Determinants of Brachytherapy Utilization for Cervical Cancer: Concerns for Widening Disparities
Authors: Boyce-Fappiano David , Nguyen Kevin A. , Gjyshi Olsi , Manzar Gohar , Abana Chike O. , Klopp Ann H. , Kamrava Mitchell , Orio Peter F. , Thaker Nikhil G. , Mourtada Firas , Venkat Puja , Chang Albert J. 
Published: September 2021

PURPOSE: Cervical cancer (CC) disproportionately affects minorities who have higher incidence and mortality rates. Standard of care for locally advanced CC involves a multimodality approach including brachytherapy (BT), which independently improves oncologic outcomes. Here, we examine the impact of insurance status and race on BT utilization with the SEER database. MATERIALS AND METHODS: In total, 7,266 patients with stage I-IV CC diagnosed from 2007 to 2015 were included. BT utilization, overall survival (OS), and disease-specific survival (DSS) were compared. RESULTS: Overall, 3,832 (52.7%) received combined external beam radiation therapy (EBRT) + BT, whereas 3,434 (47.3%) received EBRT alone. On multivariate logistic regression analysis, increasing age (OR, 0.98; 95% CI, 0.98 to 0.99; P < .001); Medicaid (OR, 0.80; 95% CI, 0.72 to 0.88; P < .001), uninsured (OR, 0.67; 95% CI, 0.56 to 0.80; P < .001), and unknown versus private insurance (OR, 0.61; 95% CI, 0.43 to 0.86; P < .001); Black (OR, 0.68; 95% CI, 0.60 to 0.77; P < .001) and unknown versus White race (OR, 0.30; 95% CI, 0.13 to 0.77; P = .047); and American Joint Committee on Cancer stage II (OR, 1.07; 95% CI, 0.93 to 1.24; P = .36), stage III (OR, 0.82; 95% CI, 0.71 to 0.94; P = .006), stage IV (OR, 0.30; 95% CI, 0.23 to 0.40; P < .001), and unknown stage versus stage I (OR, 0.36; 95% CI, 0.28 to 0.45; P < .001) were associated with decreased BT utilization. When comparing racial survival differences, the 5-year OS was 44.2% versus 50.9% ( P < .0001) and the 5-year DSS was 55.6% versus 60.5% ( P < .0001) for Black and White patients, respectively. Importantly, the racial survival disparities resolved when examining patients who received combined EBRT + BT, with the 5-year OS of 57.3% versus58.5% ( P = .24) and the 5-year DSS of 66.3% versus 66.6% ( P = .53) for Black and White patients, respectively. CONCLUSION: This work demonstrates notable inequities in BT utilization for CC that particularly affects patients of lower insurance status and Black race, which translates into inferior oncologic outcomes. Importantly, the use of BT was able to overcome racial survival differences, thus highlighting its essential value.
Circulating Plasma MicroRNA in Patients With Active Acromegaly
Authors: Lutsenko Alexander , Belaya Zhanna , Nikitin Alexey , Solodovnikov Alexander , Lapshina Anastasia , Koshkin Philipp , Vorontsova Maria , Rozhinskaya Liudmila , Melnichenko Galina , Dedov Ivan 
Published: September 2021

Abstract

Context
Excessive production of growth hormone causes marked multiorgan changes in patients with acromegaly, which may involve epigenetic mechanisms.

Objective
To evaluate differences in circulating microRNAs (miRNAs) associated with chronic growth hormone overproduction in adults.

Design and Setting
A cross-sectional case-control study was conducted at a tertiary medical center.

Participants
We enrolled 12 consecutive patients with acromegaly along with 12 age- and sex-matched controls in the discovery phase of the study and then extended this cohort to 47 patients with acromegaly and 28 healthy controls for the validation study.

Main Outcome Measures
Plasma miRNAs were quantified by next-generation sequencing (NGS) in the discovery phase. Levels of selected miRNAs were validated on extended cohorts using reverse transcription quantitative polymerase chain reaction (RT-qPCR), compared between groups, and correlated with clinical parameters.

Results
Based on NGS data, we selected 3 plasma miRNAs downregulated in patients with acromegaly compared to healthy controls: miR-4446-3p −1.317 (P = 0.001), miR-215-5p −3.040 (P = 0.005), and miR-342-5p −1.875 (P = 0.013) without multiplicity correction for all 3 miRNAs. These results were confirmed by RT-qPCR in the validation phase for 2 miRNAs out of 3: miR-4446-3p (P &lt; 0.001, Padjusted &lt; 0.001), area under the receiver-operator curve (AUC) 0.862 (95% CI 0.723-0.936; P &lt; 0.001) and miR-215-5p (P &lt; 0.001, Padjusted &lt; 0.001), AUC 0.829 (95% CI 0.698-0.907; P &lt; 0.001) to differentiate patients with acromegaly from healthy controls.

Conclusions
In a 2-phase experiment using 2 different techniques we found and validated the downregulation of plasma miR-4446-3p and miR-215-5p in patients with acromegaly compared to healthy subjects, which makes them promising biomarkers for further research.
Disaffected
Authors: Yao Xine 
Published: September 2021

In Disaffected Xine Yao explores the racial and sexual politics of unfeeling—affects that are not recognized as feeling—as a means of survival and refusal in nineteenth-century America. She positions unfeeling beyond sentimentalism's paradigm of universal feeling. Yao traces how works by Herman Melville, Martin R. Delany, Elizabeth Stuart Phelps, Frances Ellen Watkins Harper, and Sui Sin Far engaged major sociopolitical issues in ways that resisted the weaponization of white sentimentalism against the lives of people of color. Exploring variously pathologized, racialized, queer, and gendered affective modes like unsympathetic Blackness, queer female frigidity, and Oriental inscrutability, these authors departed from the values that undergird the politics of recognition and the liberal project of inclusion. By theorizing feeling otherwise as an antisocial affect, form of dissent, and mode of care, Yao suggests that unfeeling can serve as a contemporary political strategy for people of color to survive in the face of continuing racism and white fragility.
Duke University Press Scholars of Color First Book Award recipient
Targeting Sedentary Behavior in Minority Populations as a Feasible Health Strategy during and beyond COVID-19: On Behalf of ACSM-EIM and HL-PIVOT
Authors: Lassalle Patricia Pagan , Meyer Michelle L. , Conners Ryan , Zieff Gabriel , Rojas Jacklyn , Faghy Mark A. , Arena Ross , Vermeesch Amber , Joseph Rodney P. , Stoner Lee 
Published: September 2021

ABSTRACT
Increased sedentary behavior has been an unintended consequence of social and physical distancing restrictions needed to limit transmission of SARS-CoV-2, the novel coronavirus that causes COVID-19. Sedentary behavior is defined as any waking behavior characterized by an energy expenditure ≤1.5 METs while in a sitting, reclining, or lying posture. These restrictions negatively affect peoples’ cardiometabolic and mental health and disproportionately affect certain sectors of the population, including racial/ethnic minorities. In part, the higher risk for complications of COVID-19 could be the result of an increased prevalence of comorbid diseases. Further, regular participation and adherence to current physical activity guidelines, defined as at least 150 min·wk−1 of moderate-intensity physical activity or muscle strengthening activities on 2 or more days a week, is challenging for many and may be especially difficult to achieve during the COVID-19 pandemic. A practical strategy to promote health and well-being during COVID-19 is reducing sedentary behavior. Reducing sedentary behaviors (e.g., breaking up periods of prolonged sitting with light-intensity physical activity) may be more easily achieved than physical activity for all individuals, including individuals of racial/ethnic decent, as it does not require purchasing equipment nor require compromising the physical restrictions necessary to slow the spread of COVID-19. The purpose of this commentary is to argue that sedentary behavior is a feasible, independent target to modify during COVID-19, particularly in minority populations, and to address this behavior we need to consider individual, environmental, and policy-level factors.
Μοριακή και ανοστοϊστοχημική διερεύνηση της μικροδορυφορικής αστάθειας (MSI) σε καρκινώματα παχέος εντέρου
Authors: Καταφυγιώτης Πάτροκλος 
Published: September 2021

Εισαγωγή: Στην εποχή μας η ιατρική επιστήμη έχει αρχίσει να υιοθετεί την εξατομικευμένη ιατρική θεραπεία σε διάφορες παθήσεις. Καθοριστικής σημασίας στην πρόγνωση και στη θεραπεία του καρκίνου αποτελεί το μοριακό προφίλ του όγκου. Στην παρούσα αναδρομική μελέτη μελετήσαμε τα μοριακά χαρακτηριστικά και τις κλινικοπαθολογοανατομικές συσχετίσεις του ΚΠΕ σε Έλληνες ασθενείς.Υλικά και Μέθοδοι/ Ασθενείς και ΜέθοδοιΣυλλέξαμε πληροφορίες και παθολογοανατομικά δεδομένα από 157 ασθενείς με καρκίνο του παχέος εντέρου. Mετά από απομόνωση του DNA από τους κύβους παραφίνης των ασθενών, ακολούθησε PCR πραγματικού χρόνου και High Resolution Melting Analysis (HRM) για την ανίχνευση μεταλλαγών στα γονίδια KRAS, BRAF, NRAS και στους υπό διερεύνηση δείκτες μικροδορυφορικής αστάθειας (ΒΑΤ26, ΒΑΤ25, ΝR24, NR21). Οι στατιστικές συσχετίσεις πραγματοποιήθηκαν με το πακέτο SPSSv 21.0. Αποτελέσματα: Μεταλλάξεις του KRAS ανιχνεύτηκαν στο 39,3% των περιπτώσεων, του BRAF στο 10,9% και του NRAS στο 4,9%. Μικροδορυφορική αστάθεια παρατηρήθηκε στο 11,5% των ασθενών με καρκίνο του παχέος εντέρου και συσχετίστηκε με καρκινώματα του δεξιού παχέος εντέρου. Ο MSI φαινότυπος είχε αρνητική συσχέτιση με το στάδιο, την παρουσία μεταστάσεων σε λεμφαδένες καθώς και τις μεταλλάξεις του KRAS, ενώ είχε θετική συσχέτιση με μεταλλάξεις του BRAF. Συμπέρασμα: MSI θετικά καρκινώματα του παχέος εντέρου στον ελληνικό πληθυσμό είναι συχνότερα στο δεξιό παχύ έντερο, KRAS μη μεταλλαγμένα και BRAF μεταλλαγμένα. Η συλλογή περαιτέρω κλινικοπαθολογοανατομικών και μοριακών δεδομένων για κάθε πληθυσμό θα επιτρέψει στο μέλλον την καλύτερη κλινική προσέγγιση των ασθενών καθώς και την στοχευμένη θεραπεία αυτών.
Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
Authors: Ndila Carolyne M. , Nyirongo Vysaul , Macharia Alexander W. , Jeffreys Anna E. , Rowlands Kate , Hubbart Christina , Busby George B. J. , Band Gavin , Harding Rosalind M. , Rockett Kirk A. , Williams Thomas N. ,   MalariaGEN Consortium
Published: September 2021

Background: The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any confounding effects of α-thalassaemia to rule out spurious associations. Methods: In this study, we have used direct α-thalassaemia genotyping to understand why GWAS data from a large malaria association study in Kilifi Kenya did not identify the α-thalassaemia signal. We then explored the potential use of a number of new approaches to using GWAS data for imputing α-thalassaemia as an alternative to direct genotyping by PCR. Results: We found very low linkage-disequilibrium of the directly typed data with the GWAS SNP markers around α-thalassaemia and across the haemoglobin-alpha (HBA) gene region, which along with a complex haplotype structure, could explain the lack of an association signal from the GWAS SNP data. Some indirect typing methods gave results that were in broad agreement with those derived from direct genotyping and could identify an association signal, but none were sufficiently accurate to allow correct interpretation compared with direct typing, leading to confusing or erroneous results. Conclusions: We conclude that going forwards, direct typing methods such as PCR will still be required to account for α-thalassaemia in GWAS studies.
An approach to identifying young children with developmental disabilities via primary care records
Authors: Masefield Sarah C. , Prady Stephanie L. , Pickett Kate E. 
Published: September 2021

Background: Preschool aged children with developmental disabilities frequently receive a diagnosis of an indicator of disability, such as developmental delay, some time before receiving a definitive diagnosis at school age, such as autism spectrum disorder. The absence of a definitive diagnosis potentially underestimates the need for support by families with young disabled children, also delaying the access of families to condition-specific information and support. Our aim was to develop a strategy to identify children with probable and potential developmental disabilities before the age of five in primary care records for a UK birth cohort, considering how the identification of only probable or potential developmental disability might influence prevalence estimates. Methods: As part of a study of the effects of caring for young children with developmental disabilities on mothers’ health and healthcare use, we developed a two-part strategy to identify: 1) children with conditions associated with significant disability and which can be diagnosed during the preschool period; and 2) children with diagnoses which could indicate potential disability, such as motor development disorder. The strategy, using Read codes, searched the electronic records of children in the Born in Bradford cohort with linked maternal and child sociodemographic information. The results were compared with national and Bradford prevalence estimates. Results: We identified 83 children with disability conditions and 394 with potential disability (44 children had a disability condition and an indicator of potential disability). Combined they produced a developmental disability prevalence of 490 per 10,000 which is above the UK estimate for developmental disabilities in children under five (468 per 10,000) and within the 419-505 per 10,000 prevalence estimated for Bradford (for children aged 0-18). Conclusions: When disability prevalence is estimated only using conditions diagnosed as developmental disabilities, most young children with developmental disabilities likely to be diagnosed at later ages will be missed.
Prediction of Synchronization Time for Tractor Power-Shift Transmission Using Multi-Body Dynamic Simulation
Authors: Han Hyun-Woo , Han Jung-Su , Chung Woo-Jin , Kim Ji-Tae , Park Young-Jun 
Published: September 2021

HighlightsPrediction of synchronization time was performed for a power-shift transmission.We derived an analytical equation for synchronization time and developed a multi-body dynamics model.Model results were compared with results of a power-shift test on a synchronizer.Reduced computation and design time was achieved for automatic transmission design.Abstract. Synchronization time determines the capacity of a shift actuator for an automatic transmission system. Existing approaches for measuring this time only consider one rotational inertia and therefore cannot be applied to the power-shift transmission (PST) of a tractor with wet multi-plate clutches on both sides of the synchronizer. This study aims to predict the PST synchronization time by considering time-varying axial forces as first-order functions and the equivalent rotational inertias of the hub and the gear. First, we derive an analytical equation for the synchronization time. We then develop a multi-body dynamics (MBD) model that includes the drag torque of the wet multi-plate clutches. The MBD model is composed of a synchronizer, a linkage, and an output shaft of a shift actuator as a rigid-body system. A power-shift test was performed on the synchronizer at two shift stages requiring the maximum shift force of the system. The torque of the shift actuator (the input of the shift system) and the angular displacement of the output shaft of the shift actuator (the output of the shift system) were measured. The results of the simulation model were then compared with those of the shift test. Compared with the test results, the simulation results were validated within 7.63% accuracy, based on the maximum value for the torque of the shift actuator. The proposed equation was validated within a maximum error range of 8.25%. The proposed equation did not consider drag torque of the wet multi-plate clutches because that torque is much smaller than the cone torque of the synchronizer in the target shift system. The proposed equation can reduce computation time and will enable more precise sizing of the synchronizer and shift actuator in the early design stages of automatic transmissions. Keywords: Multi-body dynamics, Power-shift transmission, Synchronization time, Synchronizer, Tractor transmission.
Estudios Musicales del Clasicismo
Authors: Ortiz-de-Urbina Sobrino Paloma 
Published: September 2021

Reseña del libro Adela Presas y Miguel Salmerón (eds.), Estudios Musicales del Clasicismo. Debates estéticos sobre el teatro musical español del siglo XVIII, Madrid y Sant Cugat, Arpegio, 2019.
Mireia Freixa i Mar Léniz, El Park Güell i els seus orígens, 1894-1926, Barcelona, Museu d’Història de Barcelona - Ajuntament de Barcelona, 2019
Authors: Molet Petit Joan 
Published: September 2021

Ressenya del llibre Mireia Freixa i Mar Léniz, El Park Güell i els seus orígens, 1894-1926, Barcelona, Museu d’Història de Barcelona - Ajuntament de Barcelona, 2019.
Polititzacions del malestar. Processos creatius i experiències compartides. Exposició / Arxiu digital / publicació
Authors: Creus Castellana Maia 
Published: September 2021

Ressenya del llibre Nora ANCAROLA, Laia MANONELLES, Daniel GASOL (ed.), Polititzacions del Malestar, Barcelona, Raig Verd Editorial, 2017.
Traditional Japanese pottery and its influence on the American mid 20th century ceramic art
Authors: Tsoumas Johannis 
Published: September 2021

The Japanese ceramic tradition that was to emerge along with other forms of traditional crafts through the Mingei Movement during the interwar period, as a form of reaction to the barbaric and expansive industrialization that swept Japan from the late nineteenth century, brought to light the traditional, moral, philosophical, functional, technical and aesthetic values that had begun to eliminate. Great Japanese artists, art critics and ceramists, such as Soetsu Yanagi and Shōji Hamada, as well as the emblematic personality of the English potter Bernard Leach, after caring for the revival of Japanese pottery, believed that they should disseminate the philosophy of traditional Japanese pottery around the world and especially in the post-war U.S.A. where it found a significant response from great American potters and clay artists, but also from the educational system of the country. This article aims to focus precisely on the significant influence that postwar American ceramic art received from traditional Japanese pottery ideals. The author in order to document the reasons for this new order of things, will study and analyze the work of important American potters and ceramic artists of the time, and will highlight the social, philosophical and cultural context of the time in which the whole endeavor took place.
Power-balanced hybrid optics boosted design for achromatic extended
depth-of-field imaging via optimized mixed OTF
Authors: Rostami Seyyed Reza Miri , Pinilla Samuel , Shevkunov Igor , Katkovnik Vladimir , Egiazarian Karen 
Published: September 2021

A power-balanced hybrid optical imaging system has a diffractive computational camera, introduced in this paper, with image formation by a refractive lens and multilevel phase mask (MPM). This system provides a long focal depth with low chromatic aberrations thanks to MPM and a high energy light concentration due to the refractive lens. We introduce the concept of optical power balance between the lens and MPM, which controls the contribution of each element to modulate the incoming light. Additional features of our MPM design are the inclusion of the quantization of the MPM’s shape on the number of levels and the Fresnel order (thickness) using a smoothing function. To optimize the optical power balance as well as the MPM, we built a fully differentiable image formation model for joint optimization of optical and imaging parameters for the proposed camera using neural network techniques. We also optimized a single Wiener-like optical transfer function (OTF) invariant to depth to reconstruct a sharp image. We numerically and experimentally compare the designed system with its counterparts, lensless and just-lens optical systems, for the visible wavelength interval (400–700) nm and the depth-of-field range (0.5-

∞

m for numerical and 0.5–2 m for experimental). We believe the attained results demonstrate that the proposed system equipped with the optimal OTF overcomes its counterparts––even when they are used with optimized OTF––in terms of the reconstruction quality for off-focus distances. The simulation results also reveal that optimizing the optical power balance, Fresnel order, and the number of levels parameters are essential for system performance attaining an improvement of up to 5 dB of PSNR using the optimized OTF compared to its counterpart lensless setup.
10  W-level sub-100  ps 1  MHz MOPA laser with a microchip master oscillator
Authors: Koval V. V. , Balmashnov R. V. , Pokrovskiy V. P. , Viktorov E. A. , Kornev A. F. 
Published: September 2021

A 10 W level master oscillator power amplifier (MOPA) laser with pulse repetition rate up to 1 MHz and 75–95 ps pulse duration was developed based on a passively

Q

-switched

N
d

:

Y
V
O

4

microchip 1064 nm laser as a master oscillator. A double-rod double-end-pumping configuration of two-pass Nd:YAG ring power amplifier was used to achieve high gain, near-Fourier-transform-limited pulses, and laser beam quality factor

M

2

=

1.27

along both the horizontal and vertical directions.