bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why cosmopolitan war is an ethics of fantasy?
Authors: Garner Renaud-Philippe 
Published: September 2021

Abstract
This article argues that Fabre’s cosmopolitan war is implausible because it ignores the psychological realities of war. Building on J.L. Mackie’s notion of an ‘ethics of fantasy’ – a morality reduced to lip-service and incapable of action-guiding – I argue that a view based on a flawed view of either human agency or the context in which it is exercised is doomed to practical irrelevance. In rejecting patriotism and advancing a highly individualistic view of war, Fabre relies upon a highly flawed view of human agency, ignoring the psychological mechanism of depersonalisation essential to large-scale cooperation and the practice of war.
In Part i, I offer an initial account of what an ‘ethics of fantasy’ is and offer one major reason why certain moralities fail as practical guidance. In Part ii, I contrast Fabre’s moral cosmopolitanism with ancient cosmopolitanism; I focus on her rejection of patriotism and other identity-based forms of partiality. In Part iii, I summarise key findings, mostly in social psychology, on how large-scale social cooperation is achieved. I highlight the central role of depersonalisation and its felicity conditions. In Part iv, I argue that Fabre’s view faces a dilemma. Either her cosmopolitanism is compatible with identity-based partiality, or it is not. If not, then she does not even have a view of war given that large-scale cooperation requires it. If her view is compatible, then she needs a functional replacement for patriotism. I conclude by showing that the alternatives fail to satisfy the felicity conditions of depersonalisation which war requires.
Buchwaldoboletus xylophilus and Phlebopus portentosus,&nbsp;two non-ectomycorrhizal boletes from tropical China
Authors: XIE HUI-JING , ZHANG CHUN-XIA , HE MING-XIA , LIANG ZHI-QUN , DENG XIAO-HUA , ZENG NIAN-KAI 
Published: September 2021

Buchwaldoboletus xylophilus and Phlebopus portentosus (Boletales) are two non-ectomycorrhizal boletes, which are widely reported in tropical Asia. However, there is little information available about the taxonomy of these two boletes. Here, B. xylophilus and P. portentosus are redescribed based on morphology and molecular phylogenetic analyses of DNA sequences from nuclear 28S rDNA (28S), nuc rDNA internal transcribed spacer region ITS1-5.8S-ITS2 (ITS), translation elongation factor 1-α gene (TEF1) and the RNA polymerase II second largest subunit gene (RPB2). Detailed descriptions, color photos of fresh basidiomata, and line-drawings of microscopic features of the two taxa are presented.
Should Reversible Convective Inhibition be Used when Determining the Inflow Layer of a Convective Storm?
Authors: Murdzek Shawn S. , Markowski Paul M. , Richardson Yvette P. , Kumjian Matthew R. 
Published: September 2021

AbstractConvective inhibition (CIN) is one of the parameters used by forecasters to determine the inflow layer of a convective storm, but little work has examined the best way to compute CIN. One decision that must be made is whether to lift parcels following a pseudoadiabat (removing hydrometeors as the parcel ascends) or reversible moist adiabat (retaining hydrometeors). To determine which option is best, idealized simulations of ordinary convection are examined using a variety of base states with different reversible CIN values for parcels originating in the lowest 500 m. Parcel trajectories suggest that ascent over the lowest few kilometers, where CIN is typically accumulated, is best conceptualized as a reversible moist adiabatic process instead of a pseudoadiabatic process. Most inflow layers do not contain parcels with substantial reversible CIN, despite these parcels possessing ample convective available potential energy and minimal pseudoadiabatic CIN. If a stronger initiation method is used, or hydrometeor loading is ignored, simulations can ingest more parcels with large amounts of reversible CIN. These results suggest that reversible CIN, not pseudoadiabatic CIN, is the physically relevant way to compute CIN and that forecasters may benefit from examining reversible CIN instead of pseudoadiabatic CIN when determining the inflow layer.
Comparing the effect of a consult model versus an integrated palliative care and medical oncology co-rounding model on health care utilization in an acute hospital – an open-label stepped-wedge cluster-randomized trial
Authors: Yang Grace M , Zhou Siqin , Xu Zhizhen , Goh Stella SL , Zhu Xia , Chong Dawn QQ , Tan Daniel SW , Kanesvaran Ravindran , Yee Alethea CP , Neo Patricia SH , Cheung Yin-Bun 
Published: September 2021

Background: The benefit of specialist palliative care for cancer inpatients is established, but the best method to deliver specialist palliative care is unknown. Aim: To compare a consult model versus a co-rounding model; both provide the same content of specialist palliative care to individual patients but differ in the level of integration between palliative care and oncology clinicians. Design: An open-label, cluster-randomized trial with stepped-wedge design. The primary outcome was hospital length of stay; secondary outcomes were 30-day readmissions and access to specialist palliative care. ClinicalTrials.gov number NCT03330509. Setting/participants: Cancer patients admitted to the oncology inpatient service of an acute hospital in Singapore. Results: A total of 5681 admissions from December 2017 to July 2019 were included, of which 5295 involved stage 3-4 cancer and 1221 received specialist palliative care review. Admissions in the co-rounding model had a shorter hospital length of stay than those in the consult model by 0.70 days (95%CI −0.04 to 1.45, p = 0.065) for all admissions. In the sub-group of stage 3-4 cancer patients, the length of stay was 0.85 days shorter (95%CI 0.05–1.65, p = 0.038). In the sub-group of admissions that received specialist palliative care review, the length of stay was 2.62 days shorter (95%CI 0.63–4.61, p = 0.010). Hospital readmission within 30 days (OR1.03, 95%CI 0.79–1.35, p = 0.822) and access to specialist palliative care (OR1.19, 95%CI 0.90–1.58, p = 0.215) were similar between the consult and co-rounding models. Conclusions: The co-rounding model was associated with a shorter hospital length of stay. Readmissions within 30 days and access to specialist palliative care were similar.
Evaluation of Commercially Available Knee Cartilage Restoration Techniques Stratified by FDA Approval Pathway
Authors: Gudeman Andrew Scott , Hinckel Betina B. , Oladeji Lasun , Ray Taylor E. , Gersoff Wayne , Farr Jack , Sherman Seth L. 
Published: September 2021

Background: Commercially available products used in knee cartilage reconstructive and restorative surgical practices fall under unique US Food and Drug Administration (FDA) regulatory pathways that determine the level of evidence required to market each product. Purpose: To evaluate the levels of evidence in the literature supporting commercially available cartilage repair procedures stratified by FDA regulatory pathway (section 351 vs section 361 of “Human Cells, Tissues, and Cellular and Tissue-Based Products” [HCT/P] in the Code of Federal Regulation) with the hypothesis that products requiring approval under a stringent regulatory pathway (351 HCT/P) have higher levels of evidence in the literature supporting use and that products with a less stringent regulatory pathway (361 HCT/P) have a higher number of products available for use in the United States. Study Design: Systematic review; Level of evidence, 4. Methods: A search of the PubMed database was performed to identify all peer-reviewed articles pertaining to either allograft or autologous cartilage repair technologies. Predefined inclusion and exclusion criteria were used to find clinical, preclinical, and laboratory studies while excluding duplicates, systematic reviews, and products not available in the United States. Articles were categorized by regulatory pathway (351 and 361 HCT/P), and variables including publication year, type of publication, level of evidence, and number of publications were analyzed. Results: After application of predefined criteria, 470 of 1924 articles were included in this study. The 351 HCT/P group was composed entirely of autologous chondrocyte implantation (ACI) technology; 94% of the 361 HCT/P group was composed of osteochondral allografts (OCA). The articles regarding 351 HCT/P were more likely to be clinical in nature than the articles on 361 HCT/P (80% vs 48%, respectively; P = .0001) and entailed significantly more level 1 studies (25 vs 0, respectively; P < .0001). Twice as many articles in the 351 HCT/P group were published in the American Journal of Sports Medicine compared with the 361 HCT/P group (71 vs 38, respectively; P = .18). Conclusion: Both ACI and OCA have robust evidence supporting their use, whereas the remaining regulated products have little or no supporting evidence. Technologies regulated by 351 HCT/P were more likely to be level 1 clinical studies and published in the highest impact journal. The 361 HCT/P pathway regulated many more products, with fewer articles supporting their use.
Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting
Authors: Zhang Kejia , Zhou Xuan , Qin Jinwei , Zhang Weibing , Pan Yongchu , Wang Hua , Lin Jiuxiang , Liu Luwei , Jia Yilin 
Published: September 2021

To investigate the longitudinal influence of alveolar bone grafting on the oral microbiota of children with cleft lip and palate (CLP). Twenty-eight children with nonsyndromic CLP were recruited and underwent secondary alveolar bone grafting at the first time. Unstimulated saliva and plaque samples were collected from the subjects preoperatively and at 2 days, 1 month, and 3 months postoperatively. The v3–v4 hypervariable regions of the 16S rRNA gene from bacterial DNA were sequenced using the Illumina MiSeq sequencing platform. The alpha diversity of the saliva and plaque microbiota was significantly decreased at 2 days postoperatively and then increased at 1 and 3 months postoperatively. The saliva and plaque microbiota compositions at 2 days postoperatively differed from those at the other time points, and the microbiota compositions at 1 and 3 months postoperatively showed a gradual shift toward the preoperative composition. The saliva, but not plaque, microbiota composition 3 months postoperatively was similar to that preoperatively. The effect of secondary alveolar bone grafting on the plaque microbiota in children with CLP lasted longer than the saliva microbiota. Alveolar bone grafting altered the saliva microbiota in children with CLP within 3 months postoperatively.
Considerations When Performing Arthrodesis in the Scleroderma Hand
Authors: Long Chao , Gong Jung Ho , Lifchez Scott D. 
Published: September 2021

Background Hand deformities secondary to scleroderma can limit activities of daily living and be associated with substantial disability. This study aimed to evaluate the outcomes following arthrodesis performed to treat digital contractures secondary to scleroderma. Methods We performed a retrospective review of all patients with scleroderma who underwent arthrodesis by a single surgeon from 2015 to 2020. We collected demographic information, operative variables, and outcomes variables. Our primary outcome was occurrence of any postoperative complication, which we defined to include wound dehiscence, digital ischemia, malunion, nonunion, cellulitis, and osteomyelitis. We calculated descriptive statistics and performed all analyses at the joint level. Results We identified 9 patients who underwent arthrodesis of 19 joints. All patients were women with a mean age of 55.3 years. At the time of surgery, most patients were taking disease-modifying antirheumatic drugs (DMARDs). Kirschner wires (K-wires) were used in most cases (n = 18), 15 of which were removed uneventfully at an average of 4.8 months after surgery. With a mean follow-up time of 15.4 months, the overall complication rate was 5.3% (n = 1). This patient developed digital ischemia in 1 of 4 operative digits, which became gangrenous and required amputation. Conclusions Our study suggests that arthrodesis can be performed safely in the scleroderma hand, even when patients are taking DMARDs. Given the uneventful K-wire removal in all joints and the high risk of exposure of buried hardware in this population, we recommend nonpermanent placement of K-wires. Hand surgeons may consider arthrodesis in the scleroderma hand before proceeding to revision amputation.
Defining and treating high-grade B-cell lymphoma, NOS
Authors: Olszewski Adam J. , Kurt Habibe , Evens Andrew M. 
Published: September 2021

Abstract
High-grade B-cell lymphoma (HGBL), not otherwise specified (NOS), is a recently introduced diagnostic category for aggressive B-cell lymphomas. It includes tumors with Burkitt-like or blastoid morphology that do not have double-hit cytogenetics and that cannot be classified as other well-defined lymphoma subtypes. HBCLs, NOS, are rare and heterogeneous; most have germinal center B-cell phenotype, and up to 45% carry a single-hit MYC rearrangement, but otherwise, they have no unifying immunophenotypic or cytogenetic characteristics. Recent analyses using gene expression profiling (GEP) revealed that up to 15% of tumors currently classified as diffuse large B-cell lymphoma display an HGBL-like GEP signature, indicating a potential to significantly expand the HGBL category using more objective molecular criteria. Optimal treatment of HGBL, NOS, is poorly defined because of its rarity and inconsistent diagnostic patterns. A minority of patients have early-stage disease, which can be managed with standard R-CHOP–based approaches with or without radiation therapy. For advanced-stage HGBL, NOS, which often presents with aggressive disseminated disease, high lactate dehydrogenase, and involvement of extranodal organs (including the central nervous system [CNS]), intensified Burkitt lymphoma–like regimens with CNS prophylaxis may be appropriate. However, many patients diagnosed at age &gt;60 years are not eligible for intensive immunochemotherapy. An improved GEP- and/or genomic-based pathologic classification that could facilitate HGBL-specific trials is needed to improve outcomes for all patients. In this review, we discuss the current clinicopathologic concept of HGBL, NOS, and existing data on its prognosis and treatment and delineate potential future taxonomy enrichments based on emerging molecular diagnostics.
IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice
Authors: Kovtonyuk Larisa V. , Caiado Francisco , Garcia-Martin Santiago , Manz Eva-Maria , Helbling Patrick , Takizawa Hitoshi , Boettcher Steffen , Al-Shahrour Fatima , Nombela-Arrieta Cesar , Slack Emma , Manz Markus G. 
Published: September 2021

Abstract
Aging is associated with impaired hematopoietic and immune function caused in part by decreased fitness in the hematopoietic stem cell (HSC) population and an increased myeloid differentiation bias. The reasons for this aging-associated HSC impairment are incompletely understood. Here we demonstrate that older specific pathogen free (SPF) wild-type (WT) mice in contrast to young SPF mice produce more interleukin-1a and interleukin-1b (IL-1a/b) in steady-state bone marrow (BM), with most of the IL-1a/b being derived from myeloid BM cells. Furthermore, blood from steady-state older SPF WT mice contains higher levels of microbe-associated molecular patterns, specifically TLR4 and TLR8 ligands. In addition, BM myeloid cells from older mice produce more IL-1b in vitro, and older mice show higher and more durable IL-1a/b responses upon stimulation with lipopolysaccharide in vivo. To test whether HSC aging is driven by IL-1a/b, we evaluated HSCs from IL-1 receptor 1 (IL-1R1) knockout (KO) mice. Indeed, older HSCs from IL-1R1KO mice show significantly mitigated aging-associated inflammatory signatures. Moreover, HSCs from older IL-1R1KO and from germ-free mice maintain unbiased lymphomyeloid hematopoietic differentiation upon transplantation, thus resembling this functionality of young HSCs. Importantly, in vivo antibiotic suppression of microbiota or pharmacologic blockade of IL-1 signaling in older WT mice was similarly sufficient to reverse myeloid-biased output of their HSC populations. Collectively, our data define the microbiome/IL-1/IL-1R1 axis as a key, self-sustaining and also therapeutically partially reversible driver of HSC inflammaging.
Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells
Authors: Lichtenstein Daniel A. , Schischlik Fiorella , Shao Lipei , Steinberg Seth M. , Yates Bonnie , Wang Hao-Wei , Wang Yanyu , Inglefield Jon , Dulau-Florea Alina , Ceppi Francesco , Hermida Leandro C. , Stringaris Kate , Dunham Kim , Homan Philip , Jailwala Parthav , Mirazee Justin , Robinson Welles , Chisholm Karen M. , Yuan Constance , Stetler-Stevenson Maryalice , Ombrello Amanda K. , Jin Jianjian , Fry Terry J. , Taylor Naomi , Highfill Steven L. , Jin Ping , Gardner Rebecca A. , Shalabi Haneen , Ruppin Eytan , Stroncek David F. , Shah Nirali N. 
Published: September 2021

Abstract
Chimeric antigen receptor (CAR) T-cell toxicities resembling hemophagocytic lymphohistiocytosis (HLH) occur in a subset of patients with cytokine release syndrome (CRS). As a variant of conventional CRS, a comprehensive characterization of CAR T-cell–associated HLH (carHLH) and investigations into associated risk factors are lacking. In the context of 59 patients infused with CD22 CAR T cells where a substantial proportion developed carHLH, we comprehensively describe the manifestations and timing of carHLH as a CRS variant and explore factors associated with this clinical profile. Among 52 subjects with CRS, 21 (40.4%) developed carHLH. Clinical features of carHLH included hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia, coagulopathy, hepatic transaminitis, hyperbilirubinemia, severe neutropenia, elevated lactate dehydrogenase, and occasionally hemophagocytosis. Development of carHLH was associated with preinfusion natural killer(NK) cell lymphopenia and higher bone marrow T-cell:NK cell ratio, which was further amplified with CAR T-cell expansion. Following CRS, more robust CAR T-cell and CD8 T-cell expansion in concert with pronounced NK cell lymphopenia amplified preinfusion differences in those with carHLH without evidence for defects in NK cell mediated cytotoxicity. CarHLH was further characterized by persistent elevation of HLH-associated inflammatory cytokines, which contrasted with declining levels in those without carHLH. In the setting of CAR T-cell mediated expansion, clinical manifestations and immunophenotypic profiling in those with carHLH overlap with features of secondary HLH, prompting consideration of an alternative framework for identification and management of this toxicity profile to optimize outcomes following CAR T-cell infusion.
The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation
Authors: Amaya Maria L. , Inguva Anagha , Pei Shanshan , Jones Courtney , Krug Anna , Ye Haobin , Minhajuddin Mohammad , Winters Amanda , Furtek Steffanie L. , Gamboni Fabia , Stevens Brett , D’Alessandro Angelo , Pollyea Daniel A. , Reigan Philip , Jordan Craig T. 
Published: September 2021

Abstract
Acute myeloid leukemia (AML) is characterized by the presence of leukemia stem cells (LSCs), and failure to fully eradicate this population contributes to disease persistence/relapse. Prior studies have characterized metabolic vulnerabilities of LSCs, which demonstrate preferential reliance on oxidative phosphorylation (OXPHOS) for energy metabolism and survival. In the present study, using both genetic and pharmacologic strategies in primary human AML specimens, we show that signal transducer and activator of transcription 3 (STAT3) mediates OXPHOS in LSCs. STAT3 regulates AML-specific expression of MYC, which in turn controls transcription of the neutral amino acid transporter gene SLC1A5. We show that genetic inhibition of MYC or SLC1A5 acts to phenocopy the impairment of OXPHOS observed with STAT3 inhibition, thereby establishing this axis as a regulatory mechanism linking STAT3 to energy metabolism. Inhibition of SLC1A5 reduces intracellular levels of glutamine, glutathione, and multiple tricarboxylic acid (TCA) cycle metabolites, leading to reduced TCA cycle activity and inhibition of OXPHOS. Based on these findings, we used a novel small molecule STAT3 inhibitor, which binds STAT3 and disrupts STAT3-DNA, to evaluate the biological role of STAT3. We show that STAT3 inhibition selectively leads to cell death in AML stem and progenitor cells derived from newly diagnosed patients and patients who have experienced relapse while sparing normal hematopoietic cells. Together, these findings establish a STAT3-mediated mechanism that controls energy metabolism and survival in primitive AML cells.
CXCR4 PET/MRI for follow-up of gastric mucosa–associated lymphoid tissue lymphoma after first-line Helicobacter pylori eradication
Authors: Mayerhoefer Marius E. , Raderer Markus , Lamm Wolfgang , Weber Michael , Kiesewetter Barbara , Rohrbeck Johannes , Simonitsch-Klupp Ingrid , Hacker Marcus , Leisser Asha , Nics Lukas , Schmitl Stefan , Wester Hans-Juergen , Haug Alexander 
Published: September 2021

Abstract
Posttreatment evaluation of gastric mucosa-associated lymphoid tissue (MALT) lymphoma currently relies on esophagogastroduodenoscopy with histological assessment of biopsies. Overexpression of the G protein–coupled C-X-C chemokine receptor type 4 (CXCR4) has been previously observed in MALT lymphoma. The aim of this prospective study was to evaluate positron emission tomography (PET) with the novel CXCR4 tracer [68Ga]Pentixafor as a potential alternative to follow up biopsies for assessment of residual disease (noncomplete remission [CR]) after first-line Helicobacter pylori eradication. Forty-six post–H pylori eradication [68Ga]Pentixafor–PET/magnetic resonance imaging (MRI) examinations of 26 gastric MALT lymphoma patients, and 20 [68Ga]Pentixafor–PET/MRI examinations of 20 control group patients without lymphoma, were analyzed. In the MALT lymphoma group, time-matched gastric biopsies were used as reference standard and showed CR in 6 cases. Pooled examination-based accuracy, sensitivity, specificity, and positive and negative predictive values of [68Ga]Pentixafor–PET for detection of residual gastric MALT lymphoma at follow-up were 97.0%, 95.0%, 100.0%, 100.0%, and 92.9%, respectively. Maximum and mean PET standardized uptake values showed moderate correlation with immunohistochemistry-based CXCR4+ cell counts, with correlation coefficients of r = 0.51 and r = 0.52 (P = .008 and P = .006). In summary, CXCR4 imaging with [68Ga]Pentixafor–PET may represent a promising test for assessment of residual gastric MALT lymphomas after H pylori eradication.