bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal function and arrhythmia outcomes in persistent atrial fibrillation patients after catheter ablation: subanalysis of the EARNEST-PVI trial
Authors: Tanaka N , Inoue K , Masuda M , Furukawa Y , Hirata A , Egami Y , Watanabe T , Minamiguchi H , Miyoshi M , Okada M , Sunaga A , Sotomi Y , Dohi T , Hikoso S , Sakata Y ,   EARNEST-PVI trial
Published: October 2021

Abstract

Background
Atrial fibrillation (AF) reduces the renal function. Renal dysfunction and AF often coexist. Catheter ablation (CA) of persistent AF can maintain a sinus rhythm and may improve the renal function.

Purpose
We sought to elucidate whether the estimated glomerular filtration rate (eGFR) in patients with persistent AF was increased after CA, especially with the presence of an AF recurrence.

Methods
We enrolled 487 persistent AF patients whose eGFR data were available both before and 1-year after the CA out of 512 patients in the EARNEST-PVI trial.

Results
The mean age was 65±9 year and 113 patients (24.8%) had long-standing persistent AF. We compared the eGFR at baseline with that 1-year after the CA. AF recurrences were recognized in 118 patients (25.8%). The eGFR was similar between the group without recurrence and that with recurrence at baseline (without AF recurrence vs. with AF recurrence; 63.8±14.3 vs. 62.7±13.6 mL/min/1.73m2, p=0.46). In patients without AF recurrence, the G1, G2, G3a, G3b, G4, and G5 were 13 (3.8%), 198 (58.4%), 98 (28.9%), 26 (7.7%), 3 (0.9%), and 1 (0.3%), respectively at baseline. In the patients with AF recurrence, the G1, G2, G3a, G3b, G4, and G5 were 3 (2.5%), 68 (57.8%), 38 (32.2%), 6 (5.1%), 3 (2.5%), and 0 (0%), respectively at baseline. The ΔeGFR was significantly higher in the patients without AF recurrence than in those with AF recurrence (without AF recurrence vs. with AF recurrence; 5.1 [−0.3, 10.8] vs. 3.0 [−3.0, 7.6], p=0.0033). In the patients without AF recurrence, a better eGFR class at 1-year after the CA than in those before the CA was recognized in 75 patients (22.1%), while it was recognized in 19 patients (16.1%) with AF recurrences.

Conclusion
Successful catheter ablation in patients with persistent AF led to a better renal outcome.

Funding Acknowledgement
Type of funding sources: Private company. Main funding source(s): This study was funded by Medtronic, Johnson & Johnson, and Abbott.
Incidence of cardiovascular events in patients with atrial fibrillation anticoagulated with rivaroxaban after 2.5 years of follow-up: not all is stroke or bleeding
Authors: Anguita Sanchez M , Ruiz Ortiz M , Marin F , Sanmartin M , Rafols C , Masjuan J , Urena I , Baron Esquivias G , Lekuona I , Perez Cabeza A , Vazquez Rodriguez J.M ,   EMIR study group
Published: October 2021

Abstract

Introduction
Atrial fibrillation (AF) is not a benign arrhythmia, but is associated with an increase in mortality, above all related to the risk of suffering thromboembolic events, mainly stroke. The use of oral anticoagulants (OAC) reduces this risk, but increases the risk of serious bleeding. The DOACs have been shown to be superior to the classic vitamin K antagonists (VKAs). It is not as well known whether AF is associated with an increase in other serious cardiac events.

Purpose
The objective of this analysis was to assess the incidence of stroke, major bleeding, total mortality and major adverse cardiac events [MACE, defined as cardiac mortality (including death for coronary events, progressive heart failure death and sudden cardiac death), coronary revascularization, myocardial infarction] in a contemporary series of patients with AF anticoagulated with rivaroxaban.

Methods
To do this, we have analyzed a series of 1,433 patients with AF, anticoagulated with rivaroxaban for at least the previous 6 months, consecutively included in the first half of year 2017 in 79 Spanish centers (EMIR study), and followed for 2.5 years.

Results
Mean age was 74.2±9.7 years, 44.5% being women. Prevalence of diabetes was 27.1%, chronic renal failure 16.1%, coronary heart disease 16.4% and heart failure 22.7%. 2MACE score was 1.8±1.4, CHA2DS2-VASc was 3.5±1.5 and HAS-BLED 1.6±1.0. 77.1% of patients received 20 mg/ day of rivaroxaban and 22.9% 15 mg/day. After a follow-up of 2.5 years, the annual rate (events/100 patients/year) of myocardial infarction was 0.16 (all non-STEMI), coronary revascularization 0.28, cardiac death 0.63 (sudden 0.16, heart failure 0.41, other 0.06), overall MACE 1.07 and overall mortality 2.73, while the incidence of stroke was 0.57 / 100 patients / year (ischemic 0.35, haemorrhagic 0.22) and major bleeding 1.04 (gastrointestinal 0.63, intracranial 0.28).

Conclusion
In a current series of patients with AF anticoagulated with rivaroxaban, the incidence of embolic and hemorrhagic complications and mortality are low, while the incidence of serious cardiac events is significant, being overall similar to that of stroke and major bleeding. Attention must be paid to the prevention and diagnosis of these problems.

Funding Acknowledgement
Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Bayer Hispania
Low haemoglobin is associated with increased risk of complications in left atrial appendage closure patients
Authors: Zweiker D , Sieghartsleitner R , Toth G , Stix G , Vock P , Schratter A , Fiedler L , Aichinger J , Steinwender C , Binder R.K , Barbieri F , Ablasser K , Verheyen N , Zirlik A , Scherr D ,   the Working Group on Rhythmology, Austrian Council for Cardiology
Published: October 2021

Abstract

Introduction
Left atrial appendage closure is associated with a relevant procedural complication rate. Baseline risk factors, such as pre-procedural lab results, may identify patients that develop acute complications.

Methods
We performed a retrospective analysis of the impact of baseline characteristics and preprocedural lab results on the acute procedural outcome in patients undergoing left atrial appendage closure from the Austrian Left Atrial Appendage Closure Registry between 2010 and 2019. The endpoint for procedural complications was defined as death, stroke, major bleeding, necessity for intensive care, other complications requiring invasive interventions or failure to implant the device. We also evaluated a modified endpoint with the exclusion of bleeding events. Logistic regression was performed using stepwise approach (backward method with p_out = 0.1) and forced inclusion of age, left-ventricular function and kidney function.

Results
A total of 320 consecutive patients from 9 centres with a median age of 75 years (36.6% female) were included. Seventy-eight percent had a history of bleeding and 35% had a history of stroke. Median CHA2DS2-VASc score was 5 (interquartile range, 3–5) and median HAS-BLED score was 3 (2–4). Procedural complications occurred in 15.3% of cases. Low haemoglobin and low activated partial thromboplastin time were associated with an increased complication rate. Other significant baseline factors were liver disease, absence of intracranial haemorrhage and severe aortic stenosis. In multivariate analysis, low haemoglobin remained a significant predictor, even after adjustment for age, left-ventricular function and kidney function (Table). In the modified procedural complication endpoint excluding major bleeding events (14.1%), low haemoglobin remained a significant predictor (haemoglobin 11.9±2.0 vs. 12.8±2.0 g/dL in patients with vs. without modified endpoint, p=0.013). A baseline haemoglobin lower than 12 g/dL was present in 39.4% and it increased relative risk of procedural complications by 89% (21.4 vs. 11.3% in patients with reduced vs. normal haemoglobin), and risk of complications without bleeding by 92% (19.8 vs. 10.3%).

Conclusion
Low baseline haemoglobin is independently associated with a higher complication rate after left appendage closure compared to patients with normal haemoglobin levels, even in a modified endpoint excluding bleeding and requirement for transfusion.

Funding Acknowledgement
Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Boston Scientific - unrestricted grant Table 1
Adherence to the 4S-AF Scheme in the Balkan region: insights from the BALKAN-AF survey
Authors: Koziel M , Mihajlovic M , Nedeljkovic M , Pavlovic N , Paparisto V , Music L , Trendafilova E , Rodica Dan A , Kusljugic Z , Dan G.-A , Lip G , Potpara T ,   BALKAN-AF Investigators
Published: October 2021

Abstract

Background
Current European Society of Cardiology guidelines on atrial fibrillation (AF) propose a structured characterization of AF in order to facilitate the evaluation of patients by physicians at all healthcare levels. The 4S-AF structured scheme includes four domains: stroke risk, symptoms, severity of AF burden and substrate severity.

Purpose
To evaluate the adherence to the 4S-AF scheme in patients with high risk of stroke (CHA2DS2-VASc score ≥3 in females or ≥2 in males) in the post-hoc analysis of the BALKAN-AF dataset.

Methods
Prospective enrolment of consecutive patients with electrocardiographically documented AF was conducted in seven Balkan countries.

Results
Of the 2,712 enrolled patients, 2,712 (100.0%) had data on CHA2DS2-VASc score. 162 (6.0%) had truly low risk of stroke (CHA2DS2-VASc score of 0 in males and 1 in females). 2099 (77.4%) of patients had high risk of stroke and 613 (22.6%) individuals had low or intermediate risk of stroke (CHA2DS2-VASc score &lt;3 in females or &lt;2 in males). 75 (46.3%) of patients with truly low stroke risk and 1555 (74.1%) of patients with high risk of stroke were offered oral anticoagulants (OAC).
Of the 2,712 patients, 2,677 (98.7%) had data on European Heart Rhythm Association (EHRA) symptom score. Among 2,099 patients with high risk of stroke, 703 (33.4%) individuals had EHRA symptom score of 3 or 4. 207 (29.4%) of patients with EHRA symptom score of 3 or 4 and high risk of stroke were offered rhythm control strategy.
620 (55.2%) of patients with first diagnosed AF or paroxysmal AF with high risk of stroke were offered rhythm control strategy.
1927 (91.8%) of patients with high risk of stroke had ≥2 comorbidities. Mean left atrial diameter in patients with high risk of stroke was 46.5±7.8 mm.

Conclusions
OAC overuse was seen in patients with truly low stroke risk, whist OAC underuse was evident in patients with high risk of stroke. The proportion of highly symptomatic patients (EHRA 3 or 4) with high risk of stroke who were offered rhythm control strategy was low. The proportion of patients with first diagnosed AF or paroxysmal AF with high risk of stroke who received rhythm control was small. The majority of AF patients with high risk of stroke had ≥2 comorbidities. Overall, treatment decision-making was not based on the 4S-AF scheme.

Funding Acknowledgement
Type of funding sources: None.
A new electrophysiological triad for atrial flutter critical isthmus identification and localization
Authors: Adragao P , Nascimento Matos D , Galvao Santos P , Costa F.M , Rodrigues G , Carmo J , Carmo P , Cavaco D , Morgado F , Mendes M 
Published: October 2021

Abstract

Introduction
In a previous retrospective study it was demonstrated that an electrophysiological triad was able to identify critical isthmus in atrial flutter (AFL) patients. This triad is based in the Carto® electroanatomical mapping (EAM) version 7, which displays a histogram of the local activation times (LAT) of the tachycardia cycle length (TCL), in addition to the activation and voltage maps. This study aimed to prospectively assess the ability of an electrophysiological triad to identify and localize the AFL's critical isthmus.

Methods
Prospective analysis of a unicentric registry of individuals who underwent left AFL ablation with Carto® EAM. All patients with non-left AFL, lack of high-density EAM, less than 2000 collected points or lack of mapping in any of the left atrium walls or structures were excluded. Ablation sites of arrhythmia termination were compared to an electrophysiological triad constituted by: areas of low-voltage (0.05 to 0.3mV), sites of deep histogram valleys (LAT-Valleys) with less than 20% density points relative to the highest density zone and a prolonged LAT-Valley duration that included 10% or more of the TCL. The longest LAT-Valley was designated as the primary valley, while additional valleys were named as secondary.

Results
A total of 12 patients (9 men, median age 72 IQR 67–75 years) were included. All patients presented with left AFL and 67% had a previous atrial fibrillation and/or flutter ablation. The median TCL and number collected points were 250 (230–290) milliseconds and 3150 (IQR 2340–3870) points, respectively. All AFL presented with at least 1 LAT-Valley in the analysed histograms, which corresponded to heterogeneous low-voltage areas (0.05 to 0.3mV) and encompassed more than 10% of TCL. Eleven of the 12 patients presented with at least 1 secondary LAT-Valley. All arrhythmias were effectively terminated after undergoing radiofrequency ablation in the primary or the secondary LAT-Valley location.

Conclusion
In a prospective analysis, an electrophysiological triad was able to identify the AFL critical isthmus in all patients. Further studies are needed to assess the usefulness of this algorithm to improve catheter ablation outcomes.

Funding Acknowledgement
Type of funding sources: None.
Prognostic value of heart rate reserve during dipyridamole stress echocardiography in patients with abnormal chronotropic response to exercise
Authors: Cortigiani L , Carpeggiani C , Landi P , Raciti M , Bovenzi F , Picano E 
Published: October 2021

Abstract

Aim
To assess the prognostic meaning of HRR during dipyridamole stress echocardiography (DSE) in patients with abnormal chronotropic response to exercise.

Methods
From 2004 to 2019, we prospectively acquired and retrospectively analyzed 379 patients (age 62±11 years; ejection fraction 60±5%) with suspected (n=243) or known (n=136) chronic coronary syndromes, referred to DSE for chronotropic incompetence during upright bicycle exercise-electrocardiography test defined as HRR used [(peak HR − rest HR) / (220 − age) − rest HR] &lt;80% in patients off and &lt;62% in patients on beta-blockers. All patients were in sinus rhythm and underwent DSE (0.84 mg/kg) within 3 months of exercise testing. During DSE, age-independent HRR (peak/rest HR) &lt;1.22 was considered abnormal. All patients were followed-up. All-cause death was the only outcome measure.

Results
HRR during DSE was normal in 275 (73%) and abnormal in 104 patients (27%). During a follow-up of 9.0±4.2 years, 67 patients (18%) died. The 15-year mortality rate was 23% in patients with normal and 61% in patients with abnormal HRR (p&lt;0.0001) (Figure). At multivariable analysis a blunted HRR during DSE was an independent predictor of outcome (hazard ratio 2.01, 95% confidence intervals 1.23–3.29; p=0.005) with age and diabetes, while neither inducible ischemia nor ongoing beta-blocker therapy were significant predictors.

Conclusion
A blunted HRR during DSE predicts a worse survival in patients with chronotropic incompetence during exercise test. HRR during DSE is an appealingly simple biomarker of cardiac autonomic dysfunction independent of imaging, exercise and beta-blocker therapy.

Funding Acknowledgement
Type of funding sources: None.
Endocardial pacing compared to epicardial left ventricle pacing and right ventricle pacing: a single center long term experience in a pediatric population
Authors: Gatti P , Eliasson H , Gadler F 
Published: October 2021

Abstract

Introduction
Complete atrioventricular block (CAVB), either congenital or post heart surgery, are the main indications for cardiac pacing in the pediatric population.
Epicardial pacing is preferred in small infants or for specific cardiac anomalies and some studies highlight a superior contraction pattern when pacing epicardially from the left ventricular apex region [1–3]. Endocardial pacing is more frequently used in children with a weight &gt;20 kg and is less invasive [4].
Paced QRS duration seems to be independently associated with ventricular dysfunction irrespective of location or age at device implantation [5].

Purpose
Describe the echocardiographic and electrocardiographic changes after switch from epicardial to transvenous pacing in a pediatric population with CAVB.

Methods
Children (0–18 years), who underwent a switch from left- (LV) or right ventricle (RV) epicardial pacing to transvenous pacing at our center, were retrospectively studied. Clinical, ECG- and echocardiographic parameters before and after the switch of the PM-system were collected as well as the most recent FU data. Left ventricular end-diastolic diameter (LVDD) and fractional shortening (FS) values were transformed to a body surface-related and age-related z-score (z), respectively.

Results
Fifteen patients with CAVB who received an epicardial pacemaker (60% congenital, 40% post-cardiac surgery) were converted to a transvenous system at our center (2005–2021). The median age at the switch was 6.8 (2–13) years with a median weight of 21 (9–62) kg. The epicardial lead location was more frequently the RV wall (60%) than the LV wall (40%). The RV outflow tract and interventricular septum were the most common locations (73%) for the endocardial leads. The mean QRS duration during epicardial stimulation was 150 (IQR 26) ms vs. a median QRS duration with the transvenous system of 136 (IQR 19) ms and a median delta QRS duration of 13ms. A detailed comparison between RV and LV epicardial pacing are reported in Figure 1. Children with post-surgical AV block had a broader median QRS duration, both with epicardial and endocardial stimulation. Before the switch, there was only one abnormal observation of FS less than −2 z with normal LVDD. At the last available follow-up (mean time 7 years), all the children had normal LVDD and only one had FS less than −2 z.

Conclusions
Our report of pediatric patients after switch from epi to endo pacing, shows good results in terms of QRS duration with no significant echocardiographic or clinical evidence of deterioration of the cardiac function. Due to the small sample size the results could serve as a hypothesis generator, but larger prospective studies are needed to evaluate the electrocardiographic and echocardiographic impact of transvenous - compared to epicardial pacing.

Funding Acknowledgement
Type of funding sources: None. Comparison of QRS duration
Speckle tracking during stress echocardiography using high frame rate imaging
Authors: Orlowska M , Ramalli A , Bezy S , Voigt J.-U , D'hooge J 
Published: October 2021

Abstract

Background
As many cardiac diseases do not lead to symptoms under resting conditions, subjecting the patient to a stress (e.g. exercise) test is clinical routine to reveal disease. Quantification of cardiac function using speckle tracking echocardiography (STE) during such stress test remains a challenge not only as overall image quality typically drops but also as the heart rate increases which results in an unfavourable heart-rate-to-frame-rate ratio as required for robust tracking. Moreover, conventional STE runs at relatively low frame rate thereby under-resolving peak strain rate (SR) values – which is particularly true at high heart rates – while this biomarker has been shown to better disclose stress-induced disease than strain using Tissue Doppler Imaging (TDI)-based strain methodologies.

Purpose
The aim of this study was therefore to test whether HFR STE could reveal the strain / SR response described previously in the TDI literature.

Methods
Stress echocardiography was performed in 25 healthy volunteers at four different stress levels (baseline, 25%, 50% and 66% of maximum workload) using a supine bike. Apical 4-chamber views were recorded using the ULA-OP 256 experimental scanner running a HFR sequence based on the compounding of 6 diverging wave transmits to achieve a frame rate of 833Hz. A myocardial contour was manually drawn on the reconstructed images and tracked during the cardiac cycle by a custom-made 2D HFR STE algorithm (DOI: 10.1109/TUFFC.2020.2985451). Then, strain and strain rate curves were computed from which systolic (S) and diastolic (early (E) and late (A)) peak values, as well as the short-lived isovolumic relaxation peak (IVR) were extracted. Finally, these values were compared amongst the different stress levels using a single factor ANOVA.

Results
Some datasets had to be discarded as the contour was not properly tracked at a visual assessment of an expert cardiologist. Tracking was feasible in 92%, 98%, 80% and 64% of cases, for baseline, 25%, 50% and 66% of maximum workload, respectively. The decreasing feasibility with exercise level is in line with what is seen clinically, as volunteers' breathing is faster and heavier with increasing exercise level making the imaging more challenging. The extracted strain and SR curves showed a physiological pattern (Fig. 1a). As shown in Fig. 1b, the global systolic strain response was biphasic, showing a significant increase at low stress level but then reaching a plateau. In contrast, all SR indices linearly increased at each stress level.

Conclusion
Strain rate clinical markers extracted with HFR STE are concordant with what was reported in TDI literature. These findings show that HFR STE allows to assess cardiac function adequately during stress echocardiography.

Funding Acknowledgement
Type of funding sources: Foundation. Main funding source(s): FWO - Research Foundation Flanders
Idiopathic ventricular arrhythmias ablating from different subregions in the aortic sinus cusps: anatomic distribution, electrocardiography, and electrophysiology characteristics
Authors: Weng S.X , Zhai Z.Q , Tang M , Zhang S ,   fuwai hospital
Published: October 2021

Abstract

Background
Previous studies had described the electrocardiographic or electrophysiological characteristics of ventricular arrhythmias (VAs) from 3 aortic sinus cusps (ASC) as a whole, while little is known about the differences among VAs ablated in different subregions of the ASC.

Objective
To investigate the distribution, specific precordial electrocardiographic sign, and bipolar electrogram characteristics of VAs ablated in different subregions of the ASC.

Methods
We divided the right coronary cusp (RCC) and the left coronary cusp (LCC) into 6 subregions and studied 51 idiopathic VAs ablated successfully in the ASC.

Results
Fifty-one VAs inhomogeneous distributed in the 6 subregions, which rarely located in the lateral RCC (L-RCC; 2%). The fractionated potential was dominant (39/51, 76%) in the three kinds of target electrograms. From the L-RCC to the lateral LCC (L-LCC), the percentage of fractionated potential gradually decreased from 100% to 59%. A precordial rebound notch in V3–4 or V4–5 had a sensitivity of 90.9%, a specificity of 85.0%, and a negative predictive value (NPV) of 97.1% to predict VAs ablating from the anterior RCC (A-RCC). A precordial rebound notch in V2–3 had a sensitivity of 50.0%, a specificity of 94.9%, and a NPV of 86.0% to predict VAs ablating from the L-LCC.

Conclusion
The targets of the ASC-VAs mainly distributed in the anterior ASC and the L-LCC. Fractionated potential is common among target bipolar electrograms especially in the anterolateral RCC. Precordial electrocardiographic rebound notch has a high predictive accuracy for identifying different subregions of the ASC-VAs.

Funding Acknowledgement
Type of funding sources: None. Figure 1Figure 2