bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolving the Interactions between Class 3 Semaphorin Receptors in Live Cells
Authors: Christie Shaun M. , Hao Jing , Tracy Erin , Buck Matthias , Yu Jennifer S. , Smith Adam W. 
Published: February 2021

AbstractThe plexin/neuropilin/semaphorin family of proteins is involved with tissue patterning in the developing embryo. These proteins play roles in cell migration and adhesion, but are also important in disease, including cancer angiogenesis and metastasis. While some structures of the soluble domains of these proteins have been determined, the conformations of full-length receptor complexes are just beginning to be studied, especially within the context of the cell plasma membrane. Pulsed-interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS) allows direct insight to the formation of protein-protein interactions in the membrane of live cells. Here we investigated the homodimerization of neuropilin-1, Plexin A2, Plexin A4, and Plexin D1. Consistent with previous studies, we found that neuropilin-1, Plexin A2 and Plexin A4 are dimers in the absence of exogenous ligand. Plexin D1, on the other hand, was monomeric under similar conditions, which had not been previously reported. We also found that Plexin A2 and A4 assemble into a heteromeric complex. Stimulation with Semaphorin 3A or Semaphorin 3C ligand neither disrupts nor enhances the dimerization of the receptors when they are expressed alone, suggesting that activation involves a conformational change rather than a shift in the monomer-dimer equilibrium. However, upon stimulation with Semaphorin 3C, Plexin D1 and neuropilin-1 form a heteromeric complex, while Semaphorin 3A does not induce a stable complex with these receptors. This analysis of interactions by PIE-FCCS provides a complementary approach to the existing structural and biochemical data that will aid in the development of new therapeutic strategies to target these receptors during disease.
Chemical characterization; Antimicrobial and Larvicidal activity of essential oil fromCallistemon citrinus(Bottle brush) leaves
Authors: Chachad D. P. , Dias A. , Uniyal K. , Varma U. , Jadhav P. , Satvekar T. , Ghag – Sawant M. , Mondal M. , Doshi N. 
Published: February 2021

AbstractMosquito-borne diseases are prevalent in more than 100 countries across the world. They are the major vectors for transmission of Malaria, dengue, yellow fever, filariasis, schistosomiasis, Japanese encephalitis etc. Many of the formerly employed insecticides in mosquito control have harmful effects on human health and other non-target populations, their non-biodegradable nature, the higher rate of bio-magnification in our ecosystem and increasing insecticide resistance on global scale are raising serious concerns. . Therefore, search for natural, eco-friendly alternatives such as bio-insecticides is imperative. In this study, Larvicidal activity of the essential oil obtained from the leaves ofCallistemon citrinuswas tested on Dengue vector mosquitoAedes aegypti& Chikungunya vector mosquitoCulexsp. Also, the chemical composition of the essential oil was recorded using GC-MS analysis. The anti-microbial activity of the essential oil was checked against a few common bacteria and fungi.Callistemon citrinuscomes out to be one of such bio-insecticides with many therapeutic active constituents, showing appreciable anti-microbial activity and 80-100% larvicidal activity.
pSONIC: Ploidy-aware Syntenic Orthologous Networks Identified via Collinearity
Authors: Conover Justin L , Sharbrough Joel , Wendel Jonathan F 
Published: February 2021

ABSTRACTWith the rapid rise in availability of high-quality genomes for closely related species, methods for orthology inference that incorporate synteny are increasingly useful. Polyploidy perturbs the 1:1 expected frequencies of orthologs between two species, complicating the identification of orthologs. Here we present a method of ortholog inference, Ploidy-aware Syntenic Orthologous Networks Identified via Collinearity (pSONIC). We demonstrate the utility of pSONIC using four species in the cotton tribe (Gossypieae), including one allopolyploid, and place between 75-90% of genes from each species into nearly 32,000 orthologous groups, 97% of which consist of at most singletons or tandemly duplicated genes -- 58.8% more than comparable methods that do not incorporate synteny. We show that 99% of singleton gene groups follow the expected tree topology, and that our ploidy-aware algorithm recovers 97.5% identical groups when compared to splitting the allopolyploid into its two respective subgenomes, treating each as separate “species”.
A sequential hybrid method to establish practical sizing systems based on anthropometric data
Authors: Tjolleng Amir , Jung Kihyo , Han Hyunsook , Han Hyunjung , Cho Jayoung 
Published: February 2021

PurposeSize fit and economic efficiency are two crucial aspects that need to be considered in designing a sizing system. However, there could exist a trade-off between those aspects in order to establish a practical sizing system. The purpose of this paper is to develop a sequential hybrid method of grid and optimization to generate a practical sizing system using anthropometric data.Design/methodology/approachThe proposed sequential hybrid method consisted of two sequential steps, which employs grid method and optimization method. In the initial step, the grid method creates primary grids that accommodate a designated percentage (e.g. 90%) of users with best size fit. In the subsequent step, the optimization method generated additional grids to provide acceptable fit, with minimum fit penalty scores for users unaccommodated by the primary grids. Our method was applied to the development of a sizing system for men's military jackets. The proposed method performances were evaluated in terms of accommodation percentage, size fit and number of sizing categories.FindingsOur proposed method resulted in 26 primary grids during the initial step, which cover 90% of users. Next, we generated six additional grids during the subsequent step that provide minimum fit penalty scores for the rest (10%) users.Originality/valueThe main contributions of this paper are as follows: consider accommodation percentage, size fit and number of sizing categories in the design of sizing system; combine the grid and optimization methods and evaluate a sizing system for men's military jackets. The proposed method is applicable to develop optimal sizing systems for multiple-size products.
Testing the pecking order theory of capital structure in an Islamic legal system: the case of Saudi Arabia
Authors: Guizani Moncef , Ajmi Ahdi Noomen 
Published: February 2021

Purpose
The purpose of this paper is to examine whether the basic premises according to the pecking order theory (POT) provide an explanation for the capital structure mix of firms operating under Islamic principles.

Design/methodology/approach
Pooled ordinary least squares, fixed and random effects regressions were performed to test the POT applying data from a sample of 66 Islamic-compliant firms listed on Saudi Stock Market over the period 2006–2016.

Findings
The results show that sale-based instruments (Murabahah, Ijara) track the financial deficit quite closely followed by equity financing and as a last alternative to finance deficit, Islamic-compliant firms issue Sukuk. In the crisis period, these firms seem more reliant on equity, then on sale-based instruments and on Sukuk as last option. The study findings also indicate that the cumulative financing deficit does not wipe out the effects of conventional variables, although it is empirically significant. This provides no support for the POT attempts by Saudi Islamic-compliant firms

Research limitations/implications
This research contributes to the theory of capital structure in re-validating the findings of a previous theoretical and empirical study. It helps understand the capital structure of Islamic-compliant firms in comparison with conventional firms. It highlights some areas where further research on topics related to capital structure of Islamic-compliant firms is needed. The failure of the POT to explain Saudi firms’ financing choices strongly pushed researchers to test the market timing theory for the Saudi Stock Market. Further research studies could re-examine the trade-off theory in the absence of interest tax shield as in an Islamic economy.

Practical implications
From a managerial perspective, this research can serve firm executive managers in their financing decisions to add value to the companies. Furthermore, policymakers, bankers and standard-setting organizations should undertake more collective work to simplify the process of issuing Islamic financial instruments including Sukuk. Moreover, the Saudi Government has to encourage the private sector to be more innovative in developing products and services that are in line with Sharia principles. Finally, to attract investors, the Capital Market Authority has to encourage transaction, efficiency and liquidity of Islamic financial instruments.

Originality/value
The proposed study presents several originalities. First, it explores the implications of relevant Islamic principles on financing preferences of Saudi firms. Second, the present study enables us to investigate what the sudden abundance of liquidity, generated by the record levels of oil prices, implied for the firms’ financing behavior. Finally, it provides further evidence on the impact of financial crisis on the firms’ capital structure choice in a period of considerable slowdown in the world.
E-waste information security protection motivation: the role of optimism bias
Authors: Chen Hao , Turel Ofir , Yuan Yufei 
Published: February 2021

PurposeElectronic waste (e-waste) such as discarded computers and smartphones may contain large amounts of confidential data. Improper handling of remaining information in e-waste can, therefore, drive information security risk. This risk, however, is not always properly assessed and managed. The authors take the protection motivation theory (PMT) lens of analysis to understand intentions to protect one's discarded electronic assets.Design/methodology/approachBy applying structural equation modeling, the authors empirically tested the proposed model with survey data from 348 e-waste handling users.FindingsResults highlight that (1) protection intention is influenced by the perceived threat of discarding untreated e-waste (a threat appraisal) and self-efficacy to treat the discarded e-waste (a coping appraisal) and (2) optimism bias plays a dual-role in a direct and moderating way to reduce the perceived threat of untreated e-waste and its effect on protection intentions.Originality/valueResults support the assertions and portray a unique theoretical account of the processes that underline people's motivation to protect their data when discarding e-waste. As such, this study explains a relatively understudied information security risk behavior in the e-waste context, points to the role of optimism bias in such decisions and highlights potential interventions that can help to alleviate this information security risk behavior.
Profiting from a tainted trade: private investigators’ views on the popular culture glamorisation of their trade
Authors: King Michael 
Published: February 2021

Purpose
The public fascination for private investigators has led to an abundance of imagery in popular culture media. This study aims to examine the views of practising private investigators regarding their professional images of dirty work.

Design/methodology/approach
To fill the gap in the literature, this study used data collected from semi-structured interviews with 33 industry practitioners from 3 Australian states. The paper investigates private investigator’s perceptions about themselves/job roles and the public perceptions of private investigators in Australia. Interviews were recorded and transcripts created. A thematic analysis of the interview transcripts was undertaken.

Findings
Private investigators were drawn from a range of professions, including public policing and government regulation. The findings indicate that the reality differs from the images typically portrayed in popular culture. Interviewees discussed the contrasts between media images and reality, providing a more complex portrayal of private investigation and what private investigators find satisfying and challenging about their work.

Practical implications
This study is helpful for improving the understanding of private policing, the media views of policing, those who conduct work within an environment considered to be tainted and their views of self.

Originality/value
Using a qualitative research design, this paper offers insights into the challenges facing private investigators and how they reconcile being in a tainted occupation with providing a necessary service to the community.
A systematic review of principal time use research
Authors: Hochbein Craig , Mahone Abby , Vanderbeck Sara 
Published: February 2021

PurposeTo advance the study of principal time use (PTU), the purpose of this study is to report findings from a systematic review of PTU research. In addition to identifying common findings, this study also examined the supporting evidence and methodologies of PTU studies. From this dual approach, this study specified the evidence that supports claims about PTU, as well as identified areas requiring future examination.Design/methodology/approachA systematic reference review process considered 5,746 potential PTU manuscripts. The inclusion criteria identified 55 studies published between 1920 and 2015. This review synthesized data pertaining to the methodologies and findings of PTU research.FindingsFindings from studies conducted across decades indicated that principals worked extensive hours. Moreover, the workdays of principals consisted of brief and unrelated activities, most often focused on noninstructional tasks. Contrary to common hypotheses, studies indicated that PTU dedicated to administrative tasks exhibited positive correlations with educational outcomes. However, claims about PTU have been derived from samples overrepresented by large urban school districts and limited periods of observation.Practical implicationsFuture studies should implement diversified sampling strategies and extended observation periods. For principal preparation programs, the results indicated an opportunity for increased instruction on time management skills.Originality/valueThis systematic review identifies the overlooked history of the research and specifies the evidence that supports common claims about PTU, which provides empirically derived guidance for future PTU studies.
Relational influence on entrepreneurial orientation: an exploratory study of small religious enterprises in Brazil
Authors: Corrêa Victor Silva , Carneiro-da-Cunha Julio Araújo , Nassif Vânia Maria Jorge , Giglio Ernesto Michelangelo 
Published: February 2021

PurposeEntrepreneurial orientation (EO) is highly emerging in the management literature. However, recent studies highlight the necessity to associate with reflections on this theme, usually approached from an economic perspective, propositions also derived from relational approaches. This paper aims to investigate associations between EO and social networks, specifically about the still little explored relational coupling/decoupling theme.Design/methodology/approachThis paper provides an empirical and qualitative study of religious entrepreneurs. A total of 18 pastors responsible for creating and leading independent neo-Pentecostal churches located in Belo Horizonte/Brazil, selected using the snowball technique, participated in this qualitative, case-study research. Two analysis categories guided data collection: pastors’ EO (behaviors suggestive of their innovativeness, proactivity, competitive aggressiveness, risk-taking and autonomy) and churches’ social framework (the resources and attributes that pastors obtain from their institutional structure).FindingsThe study concludes that pastors combine attributes representing their EO and their social structure in developing their religious endeavors.Research limitations/implicationsAmong the limitations are the restricted use of semi-structured interviews as a data collection source and the absence of data proving the churches’ performance.Originality/valueThe paper contributes by showing that entrepreneurs can influence the structure of their networks by using EO; proving that networks influence pastors’ EO; revealing recursivity between EO and networks; emphasizing a relational dimension of the EO construct and presenting new theoretical propositions that can be explored and tested in future investigations.
Self-employment and economic growth in developing countries: is more self-employment better?
Authors: Yerrabati Sridevi 
Published: February 2021

PurposeThe study aims to examine the non-linear relationship between self-employment and economic growth (growth) in the context of developing countries.Design/methodology/approachData from a sample of 83 developing countries covering a period 2002–2015 is used. The empirical analysis is based on the dynamic panel data estimation, and the results are estimated using the two-step system GMM technique. Non-linearity between self-employment and growth is validated using Sasabuchi (1980) and Lind and Mehlum (2010) (SLM) test.FindingsThe empirical analysis suggests a non-linear and a U-shaped relationship between self-employment and growth, confirmed by the SLM test. The threshold levels for total self-employment, female self-employment and male self-employment are 57.49%, 58.86 and 55.81%. The findings are also robust to alternate estimation technique and alternate measure of the dependent variable.Practical implicationsPolicy implications of the findings include the need for policies that foster and channel self-employment properly as the higher level of self-employment is found to benefit growth.Originality/valueThis study is the first attempt to examine the empirical relationship between self-employment and growth. As such, it makes a novel contribution to the extant literature on the relationship between the two variables.
Stock markets' reaction to COVID-19: evidence from the six WHO regions
Authors: Al-Qudah Anas Ali , Houcine Asma 
Published: February 2021

PurposeThis study investigates the effects of the COVID-19 outbreak on daily stock returns for the six major affected WHO Regions, namely: Africa, Americas, Eastern Mediterranean, Europe, South-East Asia and Western Pacific.Design/methodology/approachThis study uses an event study method and panel-data regression models to examine the effect of the daily increase in the number of COVID-19 confirmed cases on daily stock returns from 1 March to 1 August 2020 for the leading stock market in major affected countries in the WHO regions.FindingsThe results reveal an adverse impact of the daily increasing number of COVID-19 cases on stock returns and stock markets fell quickly in response to the pandemic. The findings also suggest that negative market reaction was strong during the early stage of the outbreak between the 26th and 35th days after the initial confirmed cases. We further find that stock markets in the Western Pacific region experienced more negative abnormal returns as compared to other regions. The results also confirm that feelings of fear among investors turned out to be a mediator and a transmission channel for the effect of COVID-19 outbreak on the stock markets.Research limitations/implicationsThis study contributes to financial literature in two ways. First, we contribute to existing literature that has examined the effect of various catastrophes and crises on the stock markets Second, we contribute to the recent emerging literature that examines the impact of COVID-19 on financial markets.Practical implicationsThe study may have implications for policymakers to deal with this outbreak without triggering uncertainty in stock markets and reassure investors' confidence. The study may also be of interest to investors, managers, financial analysts by revealing how the stock markets quickly respond to outbreaks.Originality/valueThis study is the first study to examine the impact of the COVID-19 outbreak on the leading stock markets of the WHO regions.
The cyber-work performance of managers in education
Authors: Dandalt Ed 
Published: February 2021

PurposeThis study addresses the perspective of N = 273 school principals as related to technology role in performing managerial roles.Design/methodology/approachIn the context of this study, the concept of technology only refers to digital office tools such as microcomputers, email and administrative software. The concept of managerial roles is understood and used herein in relation to the definition provided by Mintzberg (2013) in his managerial typology. Moreover, a survey method was used to collect data from the aforementioned managerial employees. The managerial typology of Mintzberg was applied as a theoretical lens to collect and interpret survey data.FindingsThe findings suggest that surveyed school principals believe that technology use improves their ability to perform informational and decisional roles at work. Arguably, these managerial employees are satisfied with using technology as a labor tool for administrative and managerial work.Research limitations/implicationsThis study is limited because its sample size does not allow the findings to be generalized to all Canadian school principals. Nevertheless, the findings are significant because they suggest that similar to the positive technology-related attitude of managerial employees in business organizations, those in school organizations also perceive technology as an organizational asset. For that reason, management scholars should not only limit their studies of the intersection between technology and managerial roles or work to business organizations. They also need to extend their research studies and fieldwork to school organizations.Originality/valueThe originality of this study lies in the fact that in management literature, the intersection between technology and the managerial roles of school principals is underresearched. As such, this study represents a step forward toward the need to study the technology-related behaviors of school principals to better understand how technology use enables their workflow system.
The role of salesperson emotional behavior in value proposition co-creation
Authors: Johnson Catherine , Kaski Timo , Karsten Yvonne , Alamäki Ari , Stack Suvi 
Published: February 2021

Purpose
This paper aims to focus on how salespeople use emotions to build connections and facilitate value proposition co-creation (VPCC) in B2B complex services sales.

Design/methodology/approach
This paper uses video recordings of authentic B2B sales meetings in a two-part qualitative study.

Findings
This paper proposes a set of salesperson emotional behaviors that influence the co-creation of value propositions with customers. This paper uncovers five salesperson emotional behavior archetypes influencing VPCC.

Research limitations/implications
This study advances the value proposition literature by linking salespeople’s emotional behaviors with micro-level activities in the collaborative crafting of value propositions. The unique methodology may encourage researchers to apply video recordings in future studies.

Practical implications
The study provides managerial guidelines for improved selling competence and sales team organization.

Originality/value
This study’s findings represent a new insight into the actual manifestations of salesperson emotional behaviors that are commonly discussed but rarely observed directly.