bluuebunny/crossref_metadata_2025_split huggingface dataset:
Workplace cardiovascular risk reduction by healthcare professionals—a systematic review
Authors: Zusman E Z , Kapanen A I , Klaassen A , Reardon J 
Published: July 2021

Abstract

Background
Cardiovascular disease has a significant impact on public health and is largely preventable by addressing modifiable risk factors. As most adults spend on average half of their waking hours at work, this provides a significant opportunity to address modifiable risk factors through health promotion interventions. Healthcare professionals have the knowledge and skills to provide workplace interventions aimed at cardiovascular risk reduction.

Aims
This study was aimed to assess the literature regarding the effect of workplace interventions led by healthcare professionals on cardiovascular risk factors.

Methods
Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, MEDLINE, PsycINFO and SPORTDiscus were systematically searched from inception to March 2021. Included studies evaluated impact of workplace interventions by healthcare professionals on cardiovascular health. Data on study design, baseline characteristics, interventions, outcomes and conclusions were extracted and qualitatively analysed.

Results
Forty-five studies representing 77 633 participants were included in the analysis. Healthcare professionals involved included: nurses, nurse practitioners, physicians, dietitians, pharmacists, physician assistants, medical technicians/emergency medical technicians and physiotherapists. Workplace interventions by healthcare professionals generally improved surrogate markers of cardiovascular health. Success varied based on provider and nature of the intervention. Addressing motivation and including follow-up were key factors for successful intervention to reduce cardiovascular risk factors.

Conclusions
Workplace health promotion initiatives delivered by healthcare professionals may improve cardiovascular risk markers if they are evidence based and customized for target populations. More research is needed to determine clinical relevance of interventions and ideal interventions for specific employee groups.
Components and Functional Diversification of Florigen Activation Complexes in Cotton
Authors: Liu Hui , Huang Xianzhong , Ma Bin , Zhang Tingting , Sang Na , Zhuo Lu , Zhu Jianbo 
Published: July 2021

Abstract
In shoot apex cells of rice, a hexameric florigen activation complex (FAC), comprising flowering locus T (FT), 14-3-3 and the basic leucine zipper transcription factor FD, activates downstream target genes and regulates several developmental transitions, including flowering. The allotetraploid cotton (Gossypium hirsutum L.) contains only one FT locus in both of the A- and D-subgenomes. However, there is limited information regarding cotton FACs. Here, we identified a 14-3-3 protein that interacts strongly with GhFT in the cytoplasm and the nuclei, and five FD homoeologous gene pairs were characterized. In vivo, all five GhFD proteins interacted with Gh14-3-3 and GhFT in the nucleus. GhFT, 14-3-3 and all the GhFDs interacted in the nucleus as well, suggesting that they formed a ternary complex. Virus-induced silencing of GhFD1, -2 and -4 in cotton delayed flowering and inhibited the expression of floral meristem identity genes. Silencing GhFD3 strongly decreased lateral root formation, suggesting a function in lateral root development. GhFD overexpression in Arabidopsis and transcriptional activation assays suggested that FACs containing GhFD1 and GhFD2 function mainly in promoting flowering with partial functional redundancy. Moreover, GhFD3 was specifically expressed in lateral root meristems and dominantly activated the transcription of auxin response factor genes, such as ARF19. Thus, the diverse functions of FACs may depend on the recruited GhFD. Creating targeted genetic mutations in the florigen system using Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) genome editing may fine-tune flowering and improve plant architecture.
Intraplate Basalt Alkalinity Modulated by a Lithospheric Mantle Filter at the Dunedin Volcano (New Zealand)
Authors: Pontesilli A , Brenna M , Ubide T , Mollo S , Masotta M , Caulfield J , Le Roux P , Nazzari M , Scott J M , Scarlato P 
Published: July 2021

Abstract
Systematic variations in the crystal cargo and whole-rock isotopic compositions of mantle-derived basalts in the intraplate Dunedin Volcano (New Zealand) indicate the influence of a complex mantle-to-crust polybaric plumbing system. Basaltic rocks define a compositional spectrum from low-alkali basalts through mid-alkali basalts to high-alkali basalts. High-alkali basalts display clinopyroxene crystals with sector (hourglass) and oscillatory zoning (Mg#61–82) as well as Fe-rich green cores (Mg#43–69), whereas low-alkali basalts are characterized by clinopyroxenes with unzoned overgrowths (Mg#69–83) on resorbed mafic cores (Mg#78–88), coexisting with reversely zoned plagioclase crystals (An43–68 to An60–84 from core to rim). Complex magma dynamics are indicated by distinctive compositional variations in clinopyroxene phenocrysts, with Cr-rich zones (Mg#74–87) indicating continuous recharge by more mafic magmas. Crystallization of olivine, clinopyroxene and titanomagnetite occurred within a polybaric plumbing system extending from upper mantle to mid-crustal depths (485–1059 MPa and 1147–1286°C), whereas crystallization of plagioclase with subordinate clinopyroxene and titanomagnetite proceeded towards shallower crustal levels. The compositions of high-alkali basalts and mid-alkali basalts resemble those of ocean island basalts and are characterized by FOZO-HIMU isotopic signatures (87Sr/86Sri = 0.70277–0.70315, 143Nd/144Ndi = 0.51286–0.51294 and 206Pb/204Pb = 19.348–20.265), whereas low-alkali basalts have lower incompatible element abundances and isotopic compositions trending towards EMII (87Sr/86Sri = 0.70327–70397, 143Nd/144Ndi = 0.51282–0.51286 and 206Pb/204Pb = 19.278–19.793). High- and mid-alkali basalt magmas mostly crystallized in the lower crust, whereas low-alkali basalt magma recorded deeper upper mantle clinopyroxene crystallization before eruption. The variable alkaline character and isotope composition may result from interaction of low-alkaline melts derived from the asthenosphere with melts derived from lithospheric mantle, possibly initiated by asthenospheric melt percolation. The transition to more alkaline compositions was induced by variable degrees of melting of metasomatic lithologies in the lithospheric mantle, leading to eruption of predominantly small-volume, high-alkali magmas at the periphery of the volcano. Moreover, the lithosphere imposed a filtering effect on the alkalinity of these intraplate magmas. As a consequence, the eruption of low-alkali basalts with greater asthenospheric input was concentrated at the centre of the volcano, where the plumbing system was more developed.
Cordierite-Bearing Orbicules Record Bulk Assimilation and the Pulsating Nature of Magma Ascent: The Lafaye Orbicular Granite (France)
Authors: Barbey Pierre , Grandprat Michel , Faure François 
Published: July 2021

AbstractThe Lafaye orbicular body was emplaced in the Villatange tonalite-granodiorite unit of the Guéret magmatic complex (Massif Central, France). It consists of plagioclasic orbicules (4–35 cm diameter) embedded in homogeneous cordierite granodiorite. Orbicule cores consist mostly of residual metasedimentary xenoliths or autolithic plagioclasic cumulates. Rims (0.7–8 cm thickness) are single- or multi-layered; layers, mostly comb-textured, comprise alternating sheets dominated by cordierite (XFe = 0.32–0.37) or plagioclase (mostly An25–30). Additional mineral phases are minor biotite (XFe = 0.52; AlVI = 0.58–0.92 atoms per formula unit) and interstitial quartz. Plagioclase and cordierite morphologies (needle-like, skeletal, branching or fan-shaped) indicate growth under high initial supersaturation. However, the final polyhedral shapes and primary zoning of many individual plagioclase crystals, as well as evidence of partial recrystallization, imply significant textural maturation. Whole-rock major and trace element data (A/CNK = 1.12–1.46) and Sr and Nd isotopic compositions (εNd(355 Ma)  = −8.6 to −7.4; 87Sr/86Sr(355 Ma) = 0.7110–0.7147) suggest that the parental magma of the orbicules resulted from bulk assimilation of aluminous metasediments by a Villatange-type granodioritic magma. Heterogeneous nucleation and growth of plagioclase and cordierite around xenoliths/autoliths are interpreted in terms of (1) adiabatic decompression of magma pulses ascending in dykes leading to superheating and resorption of early solids, and (2) volatile exsolution, inducing undercooling, supersaturation, and rim crystallization. The variability of layers (number, thickness, mineral distribution, and texture) is considered to result from oscillatory crystallization combined with variable plagioclase growth rates linked to changes in the degree of supersaturation as a function of the extent of melt degassing, itself linked to magma transfer dynamics.
Membrane nanodomains and transport functions in plant
Authors: Martinière Alexandre , Zelazny Enric 
Published: July 2021

Abstract
Far from a homogeneous environment, biological membranes are highly structured with lipids and proteins segregating in domains of different sizes and dwell times. In addition, membranes are highly dynamics especially in response to environmental stimuli. Understanding the impact of the nanoscale organization of membranes on cellular functions is an outstanding question. Plant channels and transporters are tightly regulated to ensure proper cell nutrition and signaling. Increasing evidence indicates that channel and transporter nano-organization within membranes plays an important role in these regulation mechanisms. Here, we review recent advances in the field of ion, water, but also hormone transport in plants, focusing on protein organization within plasma membrane nanodomains and its cellular and physiological impacts.
Measuring the Volatility of the Political agenda in Public Opinion and News Media
Authors: Camargo Chico Q , John Peter , Margetts Helen Z , Hale Scott A 
Published: July 2021

AbstractRecent election surprises, regime changes, and political shocks indicate that political agendas have become more fast-moving and volatile. The ability to measure the complex dynamics of agenda change and capture the nature and extent of volatility in political systems is therefore more crucial than ever before. This study proposes a definition and operationalization of volatility that combines insights from political science, communications, information theory, and computational techniques. The proposed measures of fractionalization and agenda change encompass the shifting salience of issues in the agenda as a whole and allow the study of agendas across different domains. We evaluate these metrics and compare them to other measures such as issue-level survival rates and the Pedersen Index, which uses public-opinion poll data to measure public agendas, as well as traditional media content to measure media agendas in the UK and Germany. We show how these measures complement existing approaches and could be employed in future agenda-setting research.
OCCUPATIONAL DOSE ASSESSMENT FOR NUCLEAR MEDICINE AND RADIOTHERAPY TECHNOLOGISTS IN SAUDI ARABIA
Authors: Alashban Yazeed , Shubayr Nasser 
Published: July 2021

Abstract
This study estimated the occupational radiation dose received by nuclear medicine and radiotherapy technologists in Saudi Arabia. A retrospective analysis of personal dosemetry data of 1243 nuclear medicine and radiotherapy technologists from 28 medical centers across Saudi Arabia from 2015 to 2019 was conducted. Thermoluminescent dosemeters were employed to monitor the occupational radiation dose. For the study period, the average annual values for nuclear medicine and radiotherapy technologists were found to be 1.22 mSv (SD = 1.00 mSv) and 0.73 mSv (SD = 0.40 mSv) for Hp(10) and 1.23 mSv (SD = 1.07 mSv) and 0.72 mSv (SD = 0.41 mSv) for Hp(0.07), respectively. The work routines of nuclear medicine technologists cause them to be exposed to higher radiation doses than radiotherapy technologists. The occupational doses for all technologists were found to be below the annual dose limits, which indicates satisfactory working conditions in terms of radiation protection.
Anterior Quadratus Lumborum Block Does Not Provide Superior Pain Control after Hip Arthroscopy: A Double-blinded Randomized Controlled Trial
Authors: Haskins Stephen C. , Tseng Audrey , Zhong Haoyan , Mamic Marko , Cheng Stephanie I. , Nejim Jemiel A. , Wetmore Douglas S. , Coleman Struan H. , Ranawat Anil S. , Nawabi Danyal H. , Kelly Bryan T. , Memtsoudis Stavros G. 
Published: July 2021

Background
Hip arthroscopy is associated with moderate to severe postoperative pain. This prospective, randomized, double-blinded study investigates the clinically analgesic effect of anterior quadratus lumborum block with multimodal analgesia compared to multimodal analgesia alone. The authors hypothesized that an anterior quadratus lumborum block with multimodal analgesia would be superior for pain control.

Methods
Ninety-six adult patients undergoing ambulatory hip arthroscopy were enrolled. Patients were randomized to either a single-shot anterior quadratus lumborum block (30 ml bupivacaine 0.5% with 2 mg preservative-free dexamethasone) or no block. All patients received neuraxial anesthesia, IV sedation, and multimodal analgesia (IV acetaminophen and ketorolac). The primary outcome was numerical rating scale pain scores at rest and movement at 30 min and 1, 2, 3, and 24 h.

Results
Ninety-six patients were enrolled and included in the analysis. Anterior quadratus lumborum block with multimodal analgesia (overall treatment effect, marginal mean [standard error]: 4.4 [0.3]) was not superior to multimodal analgesia alone (overall treatment effect, marginal mean [standard error]: 3.7 [0.3]) in pain scores over the study period (treatment differences between no block and anterior quadratus lumborum block, 0.7 [95% CI, –0.1 to 1.5]; P = 0.059). Postanesthesia care unit antiemetic use, patient satisfaction, and opioid consumption for 0 to 24 h were not significantly different. There was no difference in quadriceps strength on the operative side between groups (differences in means, 1.9 [95% CI, –1.5 to 5.3]; P = 0.268).

Conclusions
Anterior quadratus lumborum block may not add to the benefits provided by multimodal analgesia alone after hip arthroscopy. Anterior quadratus lumborum block did not cause a motor deficit. The lack of treatment effect in this study demonstrates a surgical procedure without benefit from this novel block.

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Exponential growth of social media utilization among orthopaedic surgery residency programs: a cross-sectional study
Authors: Rodkey Daniel L. , Nelson Sarah Y. , Lundy Alexander E. , Helgeson Melvin D. 
Published: July 2021

Background:
The purpose of this study was to evaluate the extent to which orthopaedic training programs utilize social media for education, recruitment, and engagement.

Methods:
A cross-sectional study of Instagram utilization by orthopaedic surgery residency programs that were accredited by the Accreditation Council for Graduate Medical Education was performed from September 27, 2020 to October 7, 2020. If an account existed, engagement metrics including account type, number of posts, post types, number of followers, and number of accounts being followed were identified. Programs were also evaluated for US News and World Report rank, Doximity rank, program size, board pass rates, gender diversity, and years since accreditation. Accounts were analyzed using Student t-test, Spearman correlation, and regression analysis.

Results:
Of 201 accredited programs, 11 were either military or unaffiliated with the Association of American Medical Colleges. From the 190 remaining eligible programs, 91 (47.9%) had an active Instagram account. The number of programs with an account exhibited exponential growth over the past year (R2=0.93). The median number of posts was 22 (range 1 to 272), the median number of followers was 773 (range 99 to 2882), and the median number of following was 158 (range 6 to 740). Fifteen of 89 program accounts (16.9%) had a live story posted within 24 hr of review.

Conclusions:
The use of Instagram as a social media channel for orthopaedic residency programs has demonstrated exponential growth over the past year. These accounts offer unique and convenient ways to showcase a residency program. The development of a national or academy guidelines for use and content is recommended.

Level of Evidence:
Level III.
Treatment of Recalcitrant Nonunion of the Radius With Posterior Interosseous Bone Flap in Children
Authors: Kamrani Reza S. , Jehanno Pascal , Arabzadeh Aidin , Nabian Mohammad H. , Farhoud Amir R. 
Published: July 2021

Background:
Forearm nonunion is a rare condition in children, and its treatment is usually successful. However, nontraumatic nonunion can be resistant to treatment. Although the vascularized fibular bone graft has been frequently used for complex forearm nonunion, there is no consensus on the best treatment method. In this study, we aimed to investigate the outcome of the antegrade posterior interosseous bone flap (PIBF) in treating children with complex radius nonunion.

Methods:
The participants consisted of 3 girls and 1 boy ranging from 31 months to 9 years of age. They were treated with PIBF surgery, and the nonunion of the radius was fixed with a plate or an external fixator. The nonunion was due to congenital pseudoarthrosis, osteogenesis imperfecta, or infantile osteomyelitis. All patients were evaluated for a clinical and radiologic union.

Results:
The radiologic union was achieved 2 to 3 months after the surgery in all cases. The functional recovery of the elbow, forearm, and wrist was satisfactory except for 1 patient who experienced donor site fracture, and finally radioulnar synostosis accompanied by radial head dislocation.

Conclusion:
Because of the simplicity of its technique and short duration of surgery, PIBF can be a reliable and less-demanding alternative to vascularized fibular bone graft in the treatment of complex forearm nonunion in children.

Level of Evidence:
Level IV.
Development and validation of prognostic implications of chromosome abnormalities algorithm for newly diagnosed multiple myeloma
Authors: Luo Tiancheng , Qiang Wanting , Lu Jing , He Haiyan , Liu Jin , Li Lu , Jiang Hua , Fu Weijun , Du Juan 
Published: July 2021

Abstract
Fluorescence in situ hybridization (FISH) evaluation is essential for initial risk stratification in multiple myeloma (MM). The presence of specific cytogenetic abnormalities (CA) confers a heterogeneity impact on prognosis. However, the cutoff values among different centers are not uniform. Therefore, we conduct this study to better predict the prognosis of newly diagnosed MM patients based on FISH results. The Kaps method was used to calculate the chromosomal abnormal cutoff values. A total of 533 participants were included in the study. The best cutoff value of overall survival were as follows: 17p− 20.1%, 13q− 85%, 1q21+ 39%, t(11;14) 55.5%, t(14;16) 87%, and t(4;14) 53.5%. The survival analysis showed that 17p− and 1q21+ were the independent factors affecting both OS and progress free survival (PFS) among CA. The analysis based on the cutoff value obtained by Kaps suggested that 13q−, t(14;16), 17p−, and 1q21+ were independent factors affecting OS among CA; t(14;16), 17p−, and 1q21+ were independent factors affecting PFS among CA. The prognostic model was constructed by the Kaps method with the Harrell concordance index (c-index) at 0.719 (95% CI, 0.683–0.756; corrected 0.707), which was higher than that calculated by the European Myeloma Network criteria (0.714; 95% CI, 0.678–0.751; corrected 0.696). In conclusion, chromosomal abnormalities in different proportions and combinations can affect the prognosis of MM patients. Therefore, effective criteria should be formulated to evaluate the prognosis of MM patients better.
Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient
Authors: Chen Xin , Wang Bichen , Pang Aiming , Yuan Weiping , Jiang Erlie , Chu Yajing , Feng Sizhou , Han Mingzhe 
Published: July 2021

Abstract
Colony-stimulating factor 3 receptor (CSF3R) mutations have been identified in a variety of myeloid disorders. Although CSF3R point mutations (eg, T618I) are emerging as key players in chronic neutrophilic leukemia/atypical chronic myelogenous leukemia , the significance of rarer CSF3R mutations is unknown. Here, we report a 32-year-old female who was diagnosed as Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with the CSF3R M696T mutation and was undergone unrelated donor hematopoietic stem cell transplantation. The patient achieved complete remission with chemotherapy in combination with tyrosine kinase inhibitor (TKI) and long-term survival by unrelated donor transplantation. Meanwhile, we performed a series of experiments using murine interleukin 3 (IL-3)-dependent Ba/F3 cell line to evaluate the transforming capacity of the CSF3R M696T mutation. We confirmed the presence of a CSF3R M696T germline mutation in this patient which was inherited from her mother. The in vitro experiment results showed that the CSF3R M696T mutation contributes marginally to the tumor transformation of Ba/F3 cells, indicating that CSF3R M696T mutation was neutral in tumor transformation ability. We concluded that TKI is effective in patients with the CSF3R M696T mutation in Ph+ ALL and donors with CSF3R M696T mutation might still be selected as the candidate for transplantation.