bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intramuscular hematoma of the vastus lateralis following percutaneous skeletal muscle microbiopsy: a case report
Authors: Drouin Patrick J. , Islam Hashim , Simpson Craig A. , Gurd Brendon J. 
Published: October 2021

AbstractRecently, percutaneous microbiopsy needles have been used as a less invasive alternative to the Bergstrom needle for obtaining human skeletal muscle biopsy to assess changes in protein content, gene expression, and enzymatic activities. Unlike the Bergstrom muscle biopsy procedure, potential complications associated with microbiopsies of human skeletal muscle have not been documented. Therefore, the present case report follows a young male's recovery from a muscle biopsy‐induced hemorrhage/hematoma of the right vastus lateralis with the specific aims of (1) informing future participants, researchers, and clinicians on expected time course of recovery and (2) informing methods to minimize future participant adverse event risk during and after the percutaneous microbiopsy procedure. The present case report demonstrates that the inadvertent hemorrhaging of a neighboring vessel by percutaneous microbiopsy procedure can be debilitating. To minimize the risk of muscle biopsy‐induced hemorrhage/hematoma, we advise post‐biopsy compression for up to 15 min and post‐biopsy follow‐up should be completed for up to 72 h. When there is indication of hematoma development, compression should be applied, and the participant should avoid exercise and physical activity.
Birds and bovids: new parietal engravings at the Romanelli Cave, Apulia
Authors: Sigari Dario , Mazzini Ilaria , Conti Jacopo , Forti Luca , Lembo Giuseppe , Mecozzi Beniamino , Muttillo Brunella , Sardella Raffaele 
Published: October 2021

ABSTRACTThe Romanelli Cave in south-east Italy is an important reference point for the so-called ‘Mediterranean province’ of European Upper Palaeolithic art. Yet, the site has only recently been subject to a systematic investigation of its parietal and portable art. Starting in 2016, a project has recorded the cave's interior, discovering new parietal art. Here, the authors report on a selection of panels, featuring animal figures, geometric motifs and other marks, identifying the use of different types of tools and techniques, along with several activity phases. These panels are discussed with reference to radiocarbon dating of nearby deposits, posing questions about chronology, technology and wider connections between Upper Palaeolithic cave sites across western Eurasia.
Biallelic CAV1 null variants induce congenital generalized lipodystrophy with achalasia
Authors: Karhan Asuman Nur , Zammouri Jamila , Auclair Martine , Capel Emilie , Apaydin Feramuz Demir , Ates Fehmi , Verpont Marie-Christine , Magré Jocelyne , Fève Bruno , Lascols Olivier , Usta Yusuf , Jéru Isabelle , Vigouroux Corinne 
Published: October 2021

Objective
CAV1 encodes caveolin-1, a major protein of plasma membrane microdomains called caveolae, involved in several signaling pathways. Caveolin-1 is also located at the adipocyte lipid droplet. Heterozygous pathogenic variants of CAV1 induce rare heterogeneous disorders including pulmonary arterial hypertension and neonatal progeroid syndrome. Only one patient was previously reported with a CAV1 homozygous pathogenic variant, associated with congenital generalized lipodystrophy (CGL3). We aimed to further delineate genetic transmission, clinical, metabolic, and cellular characteristics of CGL3.

Design/Methods
In a large consanguineous kindred referred for CGL, we performed next-generation sequencing, as well as clinical, imagery, and metabolic investigations. We studied skin fibroblasts from the index case and the previously reported patient with CGL3.

Results
Four patients, aged 8 months to 18 years, carried a new homozygous p.(His79Glnfs*3) CAV1 variant. They all displayed generalized lipodystrophy since infancy, insulin resistance, low HDL-cholesterol, and/or high triglycerides, but no pulmonary hypertension. Two patients also presented at the age of 15 and 18 years with dysphagia due to achalasia, and one patient had retinitis pigmentosa. Heterozygous parents and relatives (n = 9) were asymptomatic, without any metabolic abnormality. Patients’ fibroblasts showed a complete loss of caveolae and no protein expression of caveolin-1 and its caveolin-2 and cavin-1 partners. Patients’ fibroblasts also displayed insulin resistance, increased oxidative stress, and premature senescence.

Conclusions
The CAV1 null variant investigated herein leads to an autosomal recessive congenital lipodystrophy syndrome. Loss of caveolin-1 and/or caveolae induces specific manifestations including achalasia which requires specific management. Overlapping phenotypic traits between the different CAV1-related diseases require further studies.
Self-assembly of biopolymer films for UV protection of wood
Authors: Fabijanic Kristina Ivana , Salinas López Aída Ninfa , Pan Long , Cheng Chi-Yuan , Wang Yu , Hao Zhigang , Potanin Andrei , Li Ningwei , Rangel Isaac 
Published: October 2021

AbstractThere is an increasing need for materials with tunable physical and chemical properties that are relatively non-toxic and efficacious for their intended application. Many wood stains and finishes emit toxic chemicals which may have serious implications to one’s health. A novel alternative material is realized between xanthan gum and Neodol, a non-ionic surfactant. The resulting three-dimensional film is evaluated as a free-radical scavenger for the protection of wood at different ratios. Atomic force microscopy visualizes the topography and quantifies the local nanomechanics, while rheological measurements showcase a shift from viscoelastic material to gel. Electron plasmon resonance confirms the free-radical reducing ability (3.5 times), while liquid chromatography mass spectroscopy quantifies the UV degradation of sinapyl alcohol. This material has potential, not only in coating industries as a safer option, but also in those industries requiring flexibility and tenability, namely for biosensors and anti-inflammatory therapeutics.
Graphic abstract
Investigation of transport behavior in borospherene-based molecular wire for rectification applications
Authors: Vohra Rajan , Kaur Harleen , Kaur Jupinder , Kumar Ravinder 
Published: October 2021

AbstractThe transport properties of molecular wire comprising of B40 fullerene are investigated by employing density functional theory (DFT) and non-equilibrium green’s function (NEGF) methodology. The quantum transport is evaluated by calculating the density of states, transmission spectra at various bias voltages, molecular energy spectra, HOMO-LUMO gap, current–voltage curve, and transmission pathways. In context to its properties, results show that by increasing the length of molecular wire, the device exhibits rectification ratio and prominent NDR behavior. I–V curve scrutinizes that as the length of wire is increased the curve becomes non-linear. This non-linear behavior is more prominent in the case when the length of wire is increased up to six fullerene cages significant rectification ratio (R.R) and negative differential resistance (NDR) comes into the picture. The excellent negative differential resistance ensures that a device with at least six molecular wires can be used as a tunnel diode.
Graphic abstract
Analgesic properties of dealcoholized extract of Acorus Calamus Leaves
Authors: Derymedvid Lyudmyla , Korang Lyudmyla 
Published: October 2021

Opioid and non-narcotic analgesics, non-steroidal anti-inflammatory agents, anesthetics, antidepressants, myorelaxants, combined agents and phytopreparations are widely used for the treatment of pain syndrome. One of the promising phytogenic objects with potential analgesic properties is the Acorus calamus (Sweet Flag).
The aim: the purpose of the study is to determine the analgesic effect of the dealcoholized extract of Acorus calamus leaves (DEAL) on a model of pain in the "Hot plate" test and in the test of tail heat immersion.
Materials and methods. During the experimental study, the pharmacological methods have been used. The analgesic properties of DEAL were studied in mice on the "Hot plate" model using the Hot / Cold Plate (Bioseb, France) and in the test of the heat immersion in rats.
The results. On the models of pain in the "Hot plate" and tail heat immersion tests, the analgesic effect of the dealcoholized extract of Acorus calamus leaves (DEAL) is determined. On the "Hot plate" model, the use of DEAL probably increased the duration of the latency period. According to the analgesic effect of DEAL and metamizol sodium were comparable to each other continues to 1 and 1.5 hours of experiment, but starting with 2 hours of experiment the analgesic action of metamizol sodium statistically exceeded the analgesic effect of DEAL.
In the test of heat immersion tail in rats, DEAL increased the latency period of shocking of the rats’ tail compared to the starting background by 43.13 % as well as metamizol sodium by 66.6 %. The studies have shown the presence of moderate analgesic effects of DEAL in the investigated dose.
Conclusions. The analgesic effect of a dealcoholized extract of Acorus calamus leaves (DEAL) on a model of pain in the "Hot plate" and heat tail immersion tests has been carried out. Under the "Hot plate" test in mice, DEAL produces a distinct analgesic effect, however, slightly inferior to the severity of metamizol sodium. Presence of moderate analgesic properties of DEAL has been verified in comparison with the metamizel sodium in thetail heat immersion test in rats. The obtained results indicate the influence of DEAL on the central mechanisms of pain formation
THE RUNTIME ANALYSIS OF COMPUTATION OF MODULAR EXPONENTIATION
Authors: Prots’ko I. , Kryvinska N. , Gryshchuk O. 
Published: October 2021

Context. Providing the problem of fast calculation of the modular exponentiation requires the development of effective algorithmic methods using the latest information technologies. Fast computations of the modular exponentiation are extremely necessary for efficient computations in theoretical-numerical transforms, for provide high crypto capability of information data and in many other applications.
Objective – the runtime analysis of software functions for computation of modular exponentiation of the developed programs based on parallel organization of computation with using multithreading.
Method. Modular exponentiation is implemented using a 2k-ary sliding window algorithm, where k is chosen according to the size of the exponent. Parallelization of computation consists in using the calculation of the remainders of numbers raised to the power of 2i modulo, and their further parallel multiplications modulo.
Results. Comparison of the runtimes of three variants of functions for computing the modular exponentiation is performed. In the algorithm of parallel organization of computation with using multithreading provide faster computation of modular exponentiation for exponent values larger than 1K binary digits compared to the function of modular exponentiation of the MPIR library. The MPIR library with an integer data type with the number of binary digits from 256 to 2048 bits is used to develop an algorithm for computing the modular exponentiation with using multithreading.
Conclusions. In the work has been considered and analysed the developed software implementation of the computation of modular exponentiation on universal computer systems. One of the ways to implement the speedup of computing modular exponentiation is developing algorithms that can use multithreading technology on multi-cores microprocessors. The multithreading software implementation of modular exponentiation with increasing from 1024 the number of binary digit of exponent shows an improvement of computation time with comparison with the function of modular exponentiation of the MPIR library.
Effect of metal ions and chemical agents on the activity of endoglucanase GH5 exploited from goats-rumen bacterial metagenomic DNA data
Authors: Khanh Hoang Viet Nguyen , Thuy Hoa Ha Thi , Nam Hai Truong , Thi Huyen Do 
Published: October 2021

A gene coding for GH5 endoglucanase exploited from metagnomic DNA data of bacteria in Vietnamese goats’ rumen was modularity structure including a catalytic module, a fibronectin-3 like module and an X module. The recombinant enzyme was sucessfully expressed in E. coli and purified. To study the effect of some metal ions and chemicals on enzyme activity, in this study, we used some tools including Swiss-Prot, ProFunc, COFACTOR for prediction of enzyme structure and ligands interaction. The obtained results indicated that the most similar structure with enzyme had two conserved residues (Asp-190 và Asp-192) linked with Mn2+ within a radius of ~ 3.5 Å from the center of ion Mn2+ and enzyme molecule contained a disulphide bond. Experimental results for essessment of the effect of some metal ions (Ca2 +, Mn2 +, Mg2+, Ni2+, K+, Co2+, Cu2+, Zn2+, Fe3+) at the final concentration of 10 mM and of six common chemicals including SDS (1%), urea (1 µM), 2-mercaptoethanol (1 µM), EDTA (1 µM), tween 80 (1mM), triton X-100 (1 µM) showed that only Mn2+ increased enzyme activity slightly at concentration of 10 mM and two times at the concentration of 40 mM Mn2+. The Mn2+ has been identified as a specific binding agent may increase the stability and activity of endoglucanase GH5.
The first experience of arthroscopy in the case of aseptic necrosis of the femoral head
Authors: Golovakha Maxim , Kirichenko Vadym , Grytsenko Olexandra , Tytarchuk Rostyslav , Bondarenko Stanislav 
Published: October 2021

Observation of patients with avascular necrosis of the femoral head formed a hypothesis about inability to eliminate the hip contracture by tunneling the femoral head on the background of drug therapy and therapeutic exercises, which causes an unsatisfactory outcomes. Therefore, the was idea to use arthroscopy for performing capsulotomy, synovectomy and removal of free cartilage and bone fragments. Objective. To evaluate efficiency of arthroscopy in patients with avascular necrosis of the femoral head. Methods. In the period from 2010 to 2018, 60 patients were observed. With the I–II stages, absence of inflammatory processes in the joint, body mass index less than 35. In the comparison group (28 patients) we made only tunneling of the femoral head, in the study group (32) at first we performed arthroscopy of the hip joint, capsulotomy, synovectomy, removal of cartilage fragments, and only then — tunneling. We analyzed the proportion of hip joint replacement that was performed in the long term follow up and the intensity of pain by visual analog scale. Results. During arthroscopy we often revealed the joint cartilage lesions — 30 %, articular labrum lesions — 5 %, synovitis — 100 %, CAM impingement — 90 %. In the study group in the first 2 weeks after surgery, the pain was severe more than in the comparison group. Then the pain rate became the same in both groups. In the control group in the period from 3 to 5 years after tunneling of the femoral head, arthroplasty was performed in 11 patients (39.3 %), in the study group for 2 to 3 years after surgery — 8 (25.0 %). Conclusions. Analysis of long-term results of tunneling of the femoral head with arthroscopy of the hip joint in patients with avascular necrosis of the femoral head showed improvement in hip function, no disease progression in 60–75 % patients in 2–3 years after surgery.
Combined soft tissue plastics in treatment of the leg infected necrotic lesions
Authors: Bets Iryna , Vyrva Oleg , Bets Grygorii 
Published: October 2021

Anatomical features of the leg create prerequisites for the occurrence of severe damage to bone-soft structures with the further development of infection-necrotic complications and osteoielitus. A difficult problem is the development of infected soft tissue defects. Objective. To study the effectiveness of the use of plastic surgical technologies using skin-fascial and muscular patches based on angiosomal concept by Taylor & Palmer. Methods. Treatment results analysis of 3 patients with necrotic defects of the leg soft tissues. All patients initially received high-energy different sites fractures of the leg bones and they were given metaloostheosynthesis using plates. In all cases, treatment was complicated by the occurrence of trophic disorders with infected full-layer defects of soft tissues that did not heal. Results. According to the angiosomal Taylor’s & Palmer’s theory, the human body is divided into 40 three-dimensional zones that combine skin with subordinate fiber and muscles, and have clear limits of blood supply to one nourishing artery. Full-haired soft-blooded patches, taking into account areas of angiosomes, are supplied throughout the plane and to the full depth, which guarantees much better results at the transplant site. The use of traditional plastics technologies in study group patients, on previous treatment did not lead to positive results, and the use of combined plastics based on the angiosomes concept allowed to obtain 100 % positive results, with complete healing of the foci of infection and the absence of relapses. Conclusions. A new stage in the development of plastic surgery, based on the angiosomes theory of human body structure by the blood supply to Taylor & Palmer, is promising for use in traumatology orthopaedics. The experience of using angiosomal patches for plastics of infected defects of the leg soft tissues has proved the high efficiency of this technology, which confirms the expediency of continuing research into the angiosomal theory in the treatment of such pathology another sites. Retrospective analysis of the etiology and pathogenesis for the leg tissues post-traumatic infected defects can be used to correct fracture treatment tactics in order to avoid the development of such complications.
Correction of hip joint instability in children with cerebral palsy — current state of the problem and prospects for its solution (literature REVIEW)
Authors: Sakalouski Oleg , Herasimenka Mihail , Klimau Roman , Hlazkin Leanid 
Published: October 2021

Hip instability in children with cerebral palsy (CP) is a serious unresolved problem in modern orthopedics. Objective. To analyze the state of the problem of the hip joint instability in children with cerebral palsy and determine the prospects for its solution. Me­thods. A thematic review of 68 studies was made. Results. The basis for the prevention of instability of the hip joint should be a systema­tic X-ray screening at least once a year. The instability of the hip joint is based on neurological disorders, if the index of migration of the femoral head (MP) is less than 30 %, the application of selective dorsal rhizotomy or baclofen pump is promising and justified. If MP > 30–100 % dorsal rhizotomy can be used after surgical correction of abnormalities in the hip joint to reduce the recurrence rate. The existing surgeries on the pelvic and femur is sufficient to restore the stability of this joint, even in the most severe cases, but the result is not always possible to maintain due to the recurrence of the deformity. The requirement for hip intervention in a patient with cerebral palsy is a preventive focus, by which we mean not only the achievement of joint stability, but also the creation of conditions for its preservation. Temporary blockage of the medial portion of the femoral head growth area is a minimally invasive procedure and may be recommended for use alone or as an adjunct to hip soft tissue release or for hip and bone surgery. However, it is still unclear at what age it is better to block the growth plate of the femoral head, whether and how often to change the clamps and so on. A prerequisite for the treatment of patients with this pathology is an individual approach, taking into account the degree of displacement of the femoral head, the presence of pathology of adjacent joints, the age of the child and the severity of the disease. Correction of existing deviations should be performed in one step at many levels.
sunny-as2: Enhancing SUNNY for Algorithm Selection
Authors: Liu Tong , Amadini Roberto , Gabbrielli Maurizio , Mauro Jacopo 
Published: October 2021

SUNNY is an Algorithm Selection (AS) technique originally tailored for Constraint Programming (CP). SUNNY is based on the k-nearest neighbors algorithm and enables one to schedule, from a portfolio of solvers, a subset of solvers to be run on a given CP problem. This approach has proved to be effective for CP problems.
In 2015, the ASlib benchmarks were released for comparing AS systems coming from disparate fields (e.g., ASP, QBF, and SAT) and SUNNY was extended to deal with generic AS problems. This led to the development of sunny-as, a prototypical algorithm selector based on SUNNY for ASlib scenarios. A major improvement of sunny-as, called sunny-as2, was then submitted to the Open Algorithm Selection Challenge (OASC) in 2017, where it turned out to be the best approach for the runtime minimization of decision problems.
In this work we present the technical advancements of sunny-as2, by detailing through several empirical evaluations and by providing new insights. Its current version, built on the top of the preliminary version submitted to OASC, is able to outperform sunny-as and other state-of-the-art AS methods, including those who did not attend the challenge.
The results of therapy of congenital adrenal hyperplasia in children in perm region
Authors: Tomilina Yulia M. , Chistousova Galina V. , Sofronova Ludmila V. 
Published: October 2021

Background. Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders. About 90% of all children with CAH have 21-hydroxylase deficiency which is required for the synthesis of glucocorticoids and mineralocorticodes. The salt-wasting form of CAH develops with a deficiency of both types of hormones. This form of CAH results in infant death if not treated, therefore early disease detection and start of treatment are very important.
Aim of research is to study the clinical features of the course of the disease and evaluate the treatment efficacy of children with salt-wasting form of CAH in the Perm region.
Materials and methods. We conducted an analysis of the clinical features of the salt-wasting form of CAH in 40 children of the Perm region. To evaluate the treatment efficacy following symptoms were analyzed: salty food craving, hyperpigmentation of skin, hirsutism, delayed or accelerated growth, etc. and parameters of water-electrolytic balance, the level of 17-hydroxyprogesterone, adrenocorticotropic hormone, renin.
Results and discussion. Despite the modern possibilities of diagnosing and treating CAH, the complete control of the disease cant be achieved in all children. Almost all the children examined had either symptoms of replacement therapy failure or overdose symptoms. Hormonal imbalance disorders were performed by a few children without any symptoms of the disease.
Conclusion. During our research we concluded that young children often have issues with an overdose of hormonal drugs and frequent occurrence of salt-wasting crises against the background of associated diseases, while for teenagers, problems associated with an insufficient dose of glucocorticoid drugs are relevant. Also, significant difficulties in the treatment of children with CAH are associated with the short action of hydrocortisone. One way to solve these problems is to organize a school for parents of children with CAH. Creating motivation, explaining the principles of treatment and importance of regular taking of drugs, as well as algorithm in medical emergency is an important step in achieving control for the disease.