bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Elucidation of Phylogenetic, Functional and Structural Features of Methioninase from Pseudomonas, Escherichia, Clostridium and Citrobacter Strains
Authors: Irajie Cambyz , Mohkam Milad , Vakili Bahareh , Nezafat Navid 
Published: September 2021

Background:
L-Methioninase (EC 4.4.1.11; MGL) is a pyridoxal
phosphate (PLP)-dependent enzyme that is produced by a variety of bacteria, fungi,
and plants. L-methioninase, especially from Pseudomonas and Citrobacter
sp., is considered as the efficient therapeutic enzyme, particularly in cancers such
as glioblastomas, medulloblastoma, and neuroblastoma that are more sensitive to
methionine starvation. Objective: The low stability is one of the main drawbacks
of the enzyme; in this regard, in the current study, different features of the enzyme,
including phylogenetic, functional, and structural from Pseudomonas,
Escherichia, Clostridium, and Citrobacter strains were evaluated to find the best
bacterial L-Methioninase.

Methods:
After the initial screening of L-Methioninase sequences from the
above-mentioned bacterial strains, the three-dimensional structures of enzymes
from Escherichia fergusonii, Pseudomonas fluorescens, and Clostridium homopropionicum
were determined through homology modeling via GalaxyTBM server
and refined by GalaxyRefine server.

Results & Conclusion:
Afterwards, PROCHECK, verify 3D, and ERRAT
servers were used for verification of the obtained models. Moreover, antigenicity,
allergenicity, and physico-chemical analysis of enzymes were also carried
out. In order to get insight into the interaction of the enzyme with other proteins,
the STRING server was used. The secondary structure of the enzyme is mainly
composed of random coils and alpha-helices. However, these outcomes should
further be validated by wet-lab investigations.
Cordycepin and its Nucleoside Analogs for the Treatment of Systemic
COVID-19 Infection
Authors: Chellapandi P. , Saranya S. 
Published: September 2021

:
Coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), a new coronavirus isolated from Wuhan, China. It is a global
health emergency, and there is no effective antiviral therapeutics available to date. Continuous
structural genomic insights of SARS-CoV-2 proteins provide a warranty for the development of rational-
based antivirals. Nevertheless, a structure-based drug candidate with multiple therapeutic actions
would be a practical choice of medication in the treatment of severe COVID-19 patients.
Cordycepin from medicinal fungi (Cordyceps spp.) and its nucleoside analogs targeting viral RNAdependent
RNA polymerase and human RNase L have potent antiviral activity against various human
viruses with additional immunomodulatory and anti-inflammatory effects. Anti-inflammation
treatment is of pivotal importance and should be timely tailored to the individual patient along with
antivirals. Our perspective on the combined antiviral and anti-inflammatory effects of cordycepin
and its analogs suggests them as new therapeutics in the treatment of systemic COVID-19 infection.
Drug Sensitivity Testing for Cancer Therapy, Technique Analysis and
Trends
Authors: Lu Da-Yong , Lu Ting-Ren 
Published: September 2021

:
The techniques and qualities of drug sensitivity testing (DST) for anticancer treatment
have grown rapidly in the past two decades worldwide. Much of DST progress came from advanced
systems of technical versatility (faster, highly-throughput, highly-sensitive, and smaller in
tumor quantity). As the earliest drug selective system, biomedical knowledge and technical advances
for DST are mutually supported. More importantly, many pharmacological controversies
are resolved by these technical advances. With this technical stride, the clinical landscape of DST
entered into a new phase (>500 samples per testing and extremely low quantity of tumor cells). As
a forerunner of the drug selection system, DST awaits a new version that can adapt to complicated
therapeutic situations and diverse tumor categories in the clinic. By upholding this goal of pathogenic
and therapeutic diversity, DST could eventually cure more cancer patients by establishing
high-quality drug selection systems. To smoothen DST development, there is a need to increase the
understanding of cancer biology, pathology and pharmacology (cancer heterogeneity, plasticity,
metastasis and drug resistance) with well-informative parameters before chemotherapy. In this article,
medicinal and technical insights into DST are especially highlighted.
A Text Messaging Intervention (StayWell at Home) to Counteract Depression and Anxiety During COVID-19 Social Distancing: Pre-Post Study
Authors: Aguilera Adrian , Hernandez-Ramos Rosa , Haro-Ramos Alein Y , Boone Claire Elizabeth , Luo Tiffany Christina , Xu Jing , Chakraborty Bibhas , Karr Chris , Darrow Sabrina , Figueroa Caroline Astrid 
Published: September 2021

Background
Social distancing and stay-at-home orders are critical interventions to slow down person-to-person transmission of COVID-19. While these societal changes help contain the pandemic, they also have unintended negative consequences, including anxiety and depression. We developed StayWell, a daily skills-based SMS text messaging program, to mitigate COVID-19–related depression and anxiety symptoms among people who speak English and Spanish in the United States.

Objective
This paper describes the changes in StayWell participants’ anxiety and depression levels after 60 days of exposure to skills-based SMS text messages.

Methods
We used self-administered, empirically supported web-based questionnaires to assess the demographic and clinical characteristics of StayWell participants. Anxiety and depression were measured using the 2-item Generalized Anxiety Disorder (GAD-2) scale and the 8-item Patient Health Questionnaire-8 (PHQ-8) scale at baseline and 60-day timepoints. We used 2-tailed paired t tests to detect changes in PHQ-8 and GAD-2 scores from baseline to follow-up measured 60 days later.

Results
The analytic sample includes 193 participants who completed both the baseline and 60-day exit questionnaires. At the 60-day time point, there were significant reductions in both PHQ-8 and GAD-2 scores from baseline. We found an average reduction of –1.72 (95% CI –2.35 to –1.09) in PHQ-8 scores and –0.48 (95% CI –0.71 to –0.25) in GAD-2 scores. These improvements translated to an 18.5% and 17.2% reduction in mean PHQ-8 and GAD-2 scores, respectively.

Conclusions
StayWell is an accessible, low-intensity population-level mental health intervention. Participation in StayWell focused on COVID-19 mental health coping skills and was related to improved depression and anxiety symptoms. In addition to improvements in outcomes, we found high levels of engagement during the 60-day intervention period. Text messaging interventions could serve as an important public health tool for disseminating strategies to manage mental health.

Trial Registration
ClinicalTrials.gov NCT04473599; https://clinicaltrials.gov/ct2/show/NCT04473599

International Registered Report Identifier (IRRID)
RR2-10.2196/23592
Promoting Safe Sleep, Tobacco Cessation, and Breastfeeding to Rural Women During the COVID-19 Pandemic: Quasi-Experimental Study
Authors: Ahlers-Schmidt Carolyn R , Schunn Christy , Hervey Ashley M , Torres Maria , Nelson Jill Elizabeth V 
Published: September 2021

Background
Safe Sleep Community Baby Showers address strategies to prevent sleep-related infant deaths. Due to the COVID-19 pandemic, these events transitioned from in-person to virtual.

Objective
This study describes outcomes of transitioning Safe Sleep Community Baby Showers to a virtual format and compares outcomes to previous in-person events.

Methods
Participants from four rural Kansas counties were emailed the presurvey, provided educational materials (videos, livestream, or digital documents), and completed a postsurvey. Those who completed both surveys received a portable crib and wearable blanket. Within-group comparisons were assessed between pre- and postsurveys; between-group comparisons (virtual vs in-person) were assessed by postsurveys.

Results
Based on data from 145 in-person and 74 virtual participants, virtual participants were more likely to be married (P<.001) and have private insurance (P<.001), and were less likely to report tobacco use (P<.001). Both event formats significantly increased knowledge and intentions regarding safe sleep and avoidance of secondhand smoke (all P≤.001). Breastfeeding intentions did not change. Differences were observed between in-person and virtual meetings regarding confidence in the ability to avoid secondhand smoke (in-person: 121/144, 84% vs virtual: 53/74, 72%; P=.03), intention to breastfeed ≥6 months (in-person: 79/128, 62% vs virtual: 52/66, 79%; P=.008), and confidence in the ability to breastfeed ≥6 months (in-person: 58/123, 47% vs virtual: 44/69, 64%; P=.02).

Conclusions
Although both event formats demonstrated increased knowledge/intentions to follow safe sleep recommendations, virtual events may further marginalize groups who are at high risk for poor birth outcomes. Strategies to increase technology access, recruit priority populations, and ensure disparities are not exacerbated will be critical for the implementation of future virtual events.
Análisis de Componentes Principales en presencia de datos faltantes: el principio de datos disponibles
Authors: Gonzalez Rojas Víctor Manuel , Conde Arango Gabriel , Ochoa Muñoz Andrés Felipe 
Published: September 2021

En este trabajo proponemos utilizar el principio de datos disponibles derivado del algoritmo NIPALS (Nonlinear estimation by Iterative Partial Least Square) para trabajar el Análisis de Componentes Principales (ACP) en presencia de datos faltantes. Esta propuesta es importante puesto que no realiza imputación de datos, ni se descartan individuos de la base datos, el método propuesto trabaja con los elementos pares disponibles para conformar las matrices de cuasicorrelación en y en la descomposición espectral de estas matrices permite a través de las relaciones de transición realizar un ACP convencional. Del estudio de simulación realizado se encontró que a medida que aumenta el porcentaje de datos faltantes disminuye la inercia explicada en el primer plano factorial. Se desarrolló el algoritmo de solución bajo el entorno de programación R y se anexa el código para uso libre.
Proposal for improving of paddy rice drying process in dryers inclined pools
Authors: Vera Duarte Luis Emilio , Moreno Gamboa Faustino , Eugenio López José Rafael 
Published: September 2021

The operation of inclined type dryers for paddy rice is studied to improve their operation and efficiency, considering the variables of drying time, humidity distribution in the rice layer after drying and air velocities within the plenum. Simulating the distribution and velocities of the air flow before crossing the rice layer, the outlet ducts to the plenum are relocated and dampers are placed to distribute the flow evenly. On the other hand, it is proposed to replace the flat-type mesh with a zigzag-type mesh. To verify the proposed modifications, a scale model was built to determine the humidity and drying time variation inside the rice layer, obtaining more uniform moisture percentages within the rice layer and a decrease in drying time.
Thoracic abscess due to unusual migration of a ventriculoperitoneal shunt and literature review
Authors: Sayore Christine Milena , Hemama Mustapha , de Paule Kossi Adjiou Francois , Moune Michele Yollande , Sabur Safa , El Fatemi Nizare , El Maaqili Rachid 
Published: September 2021

Background:
Thoracic complications of ventriculoperitoneal (VP) cerebrospinal fluid shunting are rare and the diagnosis is difficult without neurological impairment.

Case Description:
We report a case of a 36-year-old woman who had a VP shunt in the right side when she was 13 years for a posterior fossa ependymoma and hydrocephalus. 23 years after surgery, she developed acute yellowfish cough and sputum, and the computed tomography scan found an intrathoracic cyst. She had a thoracotomy for the cyst and during surgery, we found the peritoneal catheter of the VP shunt, with a collected abscess in the left side. The patient was treated for the abscess and the VP shunt was removed. We also review the literature cases of thoracic complications after VP shunts.

Conclusion:
Thoracic abscess due to VP shunt migration is extremely rare and could happen after a long time delay VP shunt surgery.
La aventura de ver con las manos
Authors: Buelvas Yury 
Published: September 2021

La posibilidad de pensar en argumentos visuales implica una reconfiguración del concepto de argumento. Implica también que se amplíe el marco, y que este incluya las diferentes formas en las que los seres humanos materializamos nuestros pensamientos. En este artículo ahondaré en las dificultades que percibo sobre la enseñanza de la lógica en un modelo tradicional educativo; para ello, me centraré en un enfoque de pluralidad, que permite inventar y crear nuevas estrategias de enseñanza de lógica multimodal para el desarrollo de diferentes habilidades, proponiendo el acercamiento de la imagen a las personas ciegas a través de la adaptación de las ilustraciones argumentales en técnicas de alto-bajo relieve, escultura manual, 2D y 3D, en el marco del proyecto de investigación Análisis lógicos de discursos.
From Hollywood
Authors: Medina Rodríguez Sandra 
Published: September 2021

Resumen: En el presente artículo se analizarán las versiones cinematográficas realizadas a partir de los cómics del guionista de historietas inglés Alan Moore (Northampton, 1953). Hasta la fecha, cuatro han sido las novelas gráficas de Moore que han sido llevadas a la pantalla: From Hell, La liga de los hombres extraordinarios, V de Vendetta y Watchmen. Asimismo, el eje de atención se centrará en las modificaciones propuestas por estos filmes, que han distorsionado y alterado la esencia y el mensaje profundo que originariamente contienen las obras de Moore.
Abstract: In this article we will analyze the film versions made from the comics of the english comic writer Alan Moore (1953, Northampton). To date, four have been Moore's graphic novels brought to the screen: From Hell, The League of Extraordinary Gentlemen, V for Vendetta and Watchmen. In our study we will identify the modifications in these films that have distorted and altered the essence and profound message contained in Moore's works.
The First Language Interference toward Students’ English Speaking as Foreign Language
Authors: Syafutri Tania , Saputra Andri 
Published: September 2021

This research aims at analyzing the first language interference toward students’ English speaking as foreign language made by sixth semester students in course design subject, such as phonological interference (pronunciation), grammatical (morphological and lexical), and lexical interference (vocabulary), and the factors that caused interference of the first language. This research is descriptive qualitative. The findings of the research explained that students made three types of interference categorized as phonological interference such as pronounce the word incorrectly (vowel, diphthong, consonan, and allophonic variation), grammatical interference such as in morphological (singular-plural agreement) and syntactical (subject-verb agreement, phrase, comparative adjective, possessive adjective, and parallel structure), and lexical interference such as in vocabulary (combining between Indonesian and the English language). The data showed that students often make error in phonological aspect. The factors that caused first language interference are lack of knowledge, Indonesian transfer, and lack of vocabularies of foreign language that mastered by students or respondents.
DAMPAK FORCE MAJEURE DALAM PEREKONOMIAN DI INDONESIA PADA MASA PANDEMI COVID-19
Authors: Amiri Kartika Septiani 
Published: September 2021

Pandemi Covid- 19 yang menyebabkan keadaan darurat di seluruh Negara khususnya di Indonesia membuat dunia binsis menjadi tidak normal karena digunakannya klausul Force majeur sebagai alat pemaaf atau sebagai alasan tidak memenuhi isi perjanjian, walaupun kadangkala fore majeure seringkali menimbulkan masalah baru dalam dunia perekonomian. Rumusan masalah penelitian ini adalah bagaimanakah dampak yang terjadi dalam perekonomian di Indonesia pada masa pandemic covid 19 dalam penggunaan klausul Force majeure ? Penelitian ini menggunakan metode pendekatan pustaka dengan hasilnya menggunakan pengumpulan data dari buku, jurnal ilmiah yang sesuai dengan judul artikel ini. Dari hasil penelusuran dan analisis bahwa penerapan klausul force majeure pada masa pandemic ini menggunakan 2 unsur atau pendekatan yaitu force majeure absolut dan force majeure relative, serta kerugian dan keadaan perekonomian yang diakibatkan hal ini Indonesia mengalami deficit yang signifikan karena sektor usaha menurun yang menyebabkan pendapatan pajak oleh Negara juga menurun sementara belanja Negara pada keadaan darurat saat ini sangat besar.
PERSPEKTIF HUKUM EKONOMI SYARIAH TERHADAP MANAJEMEN PENGELOLAAN ZAKAT PRODUKTIF DI MASA PANDEMI COVID 19 STUDI KASUS BADAN AMIL ZAKAT NASIONAL (BAZNAS) PROVINSI SULAWESI UTARA
Authors: Husein Mohamad Hidayatullah A.K 
Published: September 2021

Penataan Zakat harus menyangkut aspek manajemen modern yang dapat diandalkan, agar Zakat menjadi kekuatan yang bermakna. Penataan itu meliputi aspek pendataan, pengumpulan, penyimpanan dan pembagian, pada masa pandemic covid 19 tentu banyak permasalahan yang timbul salah satunya adalah Manajemen Zakat Produktif, dimana penelitian ini bertujuan untuk mengetahui apakah BAZNAS Provinsi Sulawesi Utara melakukan tata kelola administrasi Manajemen pada masa pandemi Covid 19 sudah sesuai dengan Prespektif Hukum Ekonomi Syariah, sehingga Tujuan dalam meningkatkan Perekonomian Para Mustahiq berjalan dengan baik.Jenis Penelitian yang digunakan adalah Kualitatif dengan pendekatan studi kasus dan Penelitian Normatif empiris yaitu penelitian hukum mengenai pemberlakuan ketentuan normatif secara langsung pada setiap peristiwa hukum yang terjadi dalam masyarakat.Dalam hasil penelitian berkaitan Manajeman Pengelolaan Zakat Produktif Pada Masa Pandemi Covid 19 sudah sesuai dengan Hukum Ekonomi Syariah dan UU. Nomor 23 Tahun 2011, akan tetapi dalam pengelolaan zakat produktif dimana faktor Sumber Daya Manusia yang masih diupayahkan karena proses pendampingan terhadap Mustahiq belum dioptimaklan dengan baik serta sosialisai tentang Zakat yang belum menyeluruh di informasikan, dengan demikian masyarakat kurang paham dengan pengelolaan dan manfaat zakat produktif. Kata Kunci: Pesrpektif Hukum Ekonomi Syariah, Zakat, Manajemen,
RESEARCH OF FORM CHANGING IN ROLLING HIGH BODIES ON ROUGHING MILLS
Authors: Samokhval V. , Chuyko V. 
Published: September 2021

Changing form workpiece in rolling high bodies has its own featuresthat must be taken into account when developing technology. One of the main technological parameters of change form, which largely determines the efficiency of processes, is the rate of spread. Known expressions for the calculation of the spread are obtained for a simple case of rolling, so that for the conditions of rolling high bodies do not provide to determine the spread with acceptable accuracy. Therefore, studies of the peculiarities of changing form during rolling of high bodies remain relevant not only for bloomings, but for rough passages on mills for the manufacture of flat and long products.
The aim of the work is to study the deformation of the metal, in particular spread, when rolling high bodies in rectangular box gauges.
To achieve this goal, the following tasks are solved in the work: design of experimentfor the study of metal spread using existing laboratory equipment; conducting an experiment, analysis of reproducibility of experiments; obtaining a model of deformation of high bodies taking into account the shape parameter of the deformation zone; comparison of the obtained results with the data of other authors and analysis of the accuracy of the model.
From the analysis of publications on dependencies for calculation of spread, a rank number of parameters influencing of spread was defined. Of this series, for the conditions of rolling high bodies, the most significant parameters are the parameter of the shape of the deformation zone and the ratio of the initial dimensions of the workpiece. Experimental studies of the effect of these parameters on the spread were performed using a single box pass embedded in the rolls of the laboratory mill 180. For the conditions and size of the caliber, an experiment of dimension 32 was planned and conducted.
According to the results of the experiment, the dependence for determining the coefficient spread when rolling high bodies in box passes was obtained. The proposed dependence provides a sufficient level of accuracy in determining the spread within the scope and can be used in the development of technology for rolling high bodies.
From the analysis of the obtained results it is also established that to correctly take into account the effect of limiting the spread of the side walls of box grooves when rolling high bodies, the research area should be spread by supplementing the obtained model with such parameters as ratio depth grooves and stock on spread in the pass.
EXPERIMENTAL STUDY OF STATIC CHARACTERISTICS ASYNCHRONOUS MACHINE IN DYNAMIC BRAKING MODE WITH INDUCTION RESISTANCE IN THE ROTOR WINDING
Authors: Kolychev S. , Sianov А. 
Published: September 2021

The article discusses the results of a study of the static electromechanical characteristics of an asynchronous machine (AM) when prototypes of induction resistances (IR) with improved parameters are included in its rotor circuits. The dynamic braking (DB) of asynchronous machines, which is widespread in practice, provides for the dissipation of the kinetic energy of the rotating parts in the resistance boxes included in the rotor winding. In the process of stopping, to maintain a constant average braking torque AM, a bulky relay-contactor circuit for shunting rotor resistances is used. However, it is not possible to eliminate significant fluctuations in the electromagnetic torque in this way. To optimize the DB AM process, it is proposed to include a three-phase IR in the rotor winding instead of resistance boxes, the value of which automatically decreases along with the rotor current frequency. This approach allows you to abandon contact equipment and ensure smooth braking of the machine with fluctuations in the electromagnetic moment in narrower limits. The known IR designs are designed for starting modes of induction motors with a wound rotor, but they cannot ensure the constancy of the torque on the AM shaft in the DB mode. Therefore, the purpose of the study is to develop and experimentally confirm the effectiveness of simple control circuits of an induction machine in the specified mode with improved contactless induction rheostats in the rotor. The paper presents a diagram of a pilot plant and a figure explaining the design features of the IR. The studies were carried out for an asynchronous machine of the MTB-412-8 type, equipped with a thyristor exciter and a tachogenerator. The three phases of the AM rotor included ICs connected by a "star". The experiments were carried out in the direction of obtaining the necessary braking characteristics of the AM by varying the switching circuit of the stator phases and the value of the current supplying them. The figures show the mechanical characteristics of AM, obtained in the process of studying the influence on them of three typical circuits for switching on the phases of the stator winding and two values ​​of the fixed supply current. The research results show that the desired form of the mentioned AM characteristics is achieved only when using the stator phase switching in a function of the rotor speed and a constant supply current value.