bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients With Hereditary Angioedema Do Not Develop More Severe COVID-19 but SARS-CoV-2&nbsp;Infection May Trigger Attacks: 66 Cases
Authors: Olivares Maria Margarita , Zwiener Ricardo Dario , Panqueva Lina Maria Leiva , Verduzco Francisco Alberto Contreras , Mansour Eli , Rodriguez Jairo Antonio , Valle Solange Oliveira Rodrigues , Nieto Sandra , Silva Jane Da , Vazquez Daniel O , Llosa Oscar Calderon , Marcelino Fernanda Casares , Ratti-Sisa Manuel , Beas Ileana María Madrigal , Zaragoza-Urdaz Rafael , Toledo Eliana Cristina , Fili Natalia Lorena , Barrero Olga M , Aguirre Juan Carlos Fernandez de Cordova , Mora Sergio Castro , Sarrazola Mauricio , Raad Rodolfo Jaller , Cardenas Edison Morales , Josviak Dario Oscar , Fantini Claudio , Marocco Monica , Nievas Elma I , Serpa Faradiba Sarquis , Neto Herberto Jose Chong , Alonso Maria Luiza Oliva , Junior Sergio Dortas , Ulaf Raisa Gusso , Rosario Nelson , Barrero Rodolfo Ramón Leyva , Grumach Anete Sevciovic 
Published: April 2021

Abstract
PurposeHereditary angioedema (HAE) is a rare genetic disease with hyperactivated contact and kallikrein-kinin systems leading to bradykinin (BK) release and edema. SARS-CoV-2 infection results in inflammatory exacerbation. C1 inhibitor (C1-INH) deficiency could aggravate clinical outcomes, with HAE patients at a greater risk of adverse outcomes of COVID-19, however, data are still limited. Our aim was to characterize the course and severity of COVID-19 in patients with HAE.MethodsLatin American HAE reference centers evaluated SARS-CoV-2 infection in this population. Patients with confirmed diagnosis of HAE with (HAE-C1-INH) or without C1-INH deficiency (HAE-nC1-INH) were included. HAE symptomatology and the course of COVID-19 were characterized with the application of a questionnaire. Results66 patients from 10 countries (HAE-C1-INH 80,3%; HAE-nC1-INH 19.6%) were reported with SARS-CoV-2 infection. Comorbidities were absent in 69.7% of the patients and obesity present in 12.1%. Attacks occurred in 45.5% of patients with HAE during SARS-CoV-2 infection. Long term prophylaxis was reported in 52% (34/66) of HAE patients. Complete cure was observed in 61 patients (92.4%), pulmonary sequelae in 4 and death in one HAE-C1-INH patient. The cause of death was septic shock secondary to bacterial pulmonary coinfection. Disease progression was not impacted by sex, therapy or type of HAE (p = 0.803). Conclusion﻿Attacks occurred in almost half of HAE patients suggesting that SARS-CoV-2 infection is a trigger. HAE did not represent a risk factor for a worse outcome of COVID-19, even in use of androgens.
Effect of Diets With Different Lysine Levels on the Hemograms of Juvenile Tambaqui Colosssoma Macropomum (CUVIER, 1818)
Authors: Liebl Ariany Rabello da Silva , Nascimento Marcelo dos Santos , Castro Philp Dalbert da Silva , Aride Paulo Henrique Rocha , Bussons Márcia Regina Fragoso Machado , Faggio Caterina , Oliveira Adriano Teixeira de 
Published: April 2021

Abstract
Blood transports lysine and other nutrients derived from the diet and ensures good health and greater productivity for the fish. Therefore, this study aimed to verify the hematological behavior of juvenile tambaqui Colossoma macropomum nourished with levels of 9.72, 12.84, 15.96, 19.08 and 22.20 g.Kg-1 of total lysine, corresponding, respectively, to the supplementation levels with L-lysine: 0.00, 4.00, 8.00, 12.00, 16.00 and 20.00 g.Kg-1 of L-lysine. The blood of the fish was collected in the initial and final periods by puncture of the caudal vein. The variables were validated by ANOVA and Tukey's test (p< 0.05). No differences were found for hemoglobin, hematocrit, CHCM, leukocytes of the eosinophil and monocyte types, and thrombocytes (p> 0.05). The changes observed in total leukocytes were not attributed to diets (p= 0.00). Means of CMV, HCM, lymphocytes and neutrophils, varied over the initial period, but not in regard to different lysine levels (p< 0.05). Thus, it is concluded that the varying lysine levels of the diets did not compromise the hematological parameters analyzed.
A Novel Weighting Method to Remove Bias from Within-subject Exposure Dependency in Case-crossover Studies
Authors: Kubota Kiyoshi , Kelly Lan , Sato Tsugumichi , Pratt Nicole , Roughead Elizabeth , Yamaguchi Takuhiro 
Published: April 2021

Abstract
Background:Case-crossover studies have been widely used in various fields including pharmacoepidemiology. Vines and Farrington indicated in 2001 that when within-subject exposure dependency exists, conditional logistic regression can be biased. However, this bias has not been well studied.Methods:We have extended findings by Vines and Farrington to develop a weighting method for the case-crossover study which removes bias from within-subject exposure dependency. Our method calculates the exposure probability at the case period in the case-crossover study which is used to weight the likelihood formulae presented by Greenland in 1999. We simulated data for the population with a disease where most patients receive a cyclic treatment pattern with within-subject exposure dependency but no time trends while some patients stop and start treatment. Finally, the method was applied to real-world data from Japan to study the association between celecoxib and peripheral edema and to study the association between selective serotonin reuptake inhibitor (SSRI) and hip fracture in Australia.Results:When the simulated rate ratio of the outcome was 4.0 in a case-crossover study with no time-varying confounder, the proposed weighting method and the Mantel-Haenszel odds ratio reproduced the true rate ratio. When a time-varying confounder existed, the Mantel-Haenszel method was biased but the weighting method was not. When more than one control period was used, standard conditional logistic regression was biased either with or without time-varying confounding and the bias increased (up to 9.4) when the study period was extended. In real-world analysis with a binary exposure variable in Japan and Australia, the point estimate of the odds ratio (around 2.5 for the association between celecoxib and peripheral edema and around 1.6 between SSRI and hip fracture) by our weighting method was equal to the Mantel-Haenszel odds ratio and stable compared with standard conditional logistic regression. Conclusion:Case-crossover studies may be biased from within-subject exposure, even without exposure time trends. This bias can be identified by comparing the odds ratio calculated by the Mantel-Haenszel method and that by standard conditional logistic regression. Our proposed method will remove bias from within-subject exposure dependency and can account for time-varying confounders.
Covid-19 Related Poor Mental Health and Sleep Disorders in Rheumatic Patients: a Citizen Science Project.
Authors: Ingegnoli Francesca , Buoli Massimiliano , Posio Cristina , Taranto Raffaele Di , Muscio Alessandro Lo , Cumbo Enrico , Ostuzzi Silvia , Caporali Roberto 
Published: April 2021

Abstract
BACKGROUND Patients with chronic rheumatic diseases (RDs) are more vulnerable and the containment measures related to COVID-19 pandemic might have severe psychological consequences. We investigated the presence of and risk factors associated with poor mental health, sleep disorders among RDs during the pandemic.METHODS This cross-sectional Italian citizen science project evaluated the psychological impact of the COVID-19 pandemic in patients with RDs. Between May and September 2020, eleven RD patients’ associations sent the survey by using their mailing list and the related webpage and social network. 507 RD patients completed an ad-hoc anonymous online survey including the Perceived Stress Scale (PSS) and Impact Event Scale-Revised (IES-R). RESULTS The mean scores on the PSS-10 and the IES-R were 18.1 and 29.7, respectively. Higher PSS scores were associated with younger age (p<0.01), female gender (p<0.01), overweight/obesity (p=0.01), psychiatric pharmacotherapy (p<0.01), and anxiety for loss of income (p<0.01). Higher IES-R scores were associated with female gender (p<0.01), intestinal diseases (p=0.03), anxiety (p<0.01), and health concern (p<0.01). Among 375 of patients with inflammatory arthritis, 246 (65.6%) had trouble staying asleep, 238 (63.5%) in falling asleep, and 112 (29.9%) had dreams about the pandemic. Older age (OR= 1.038, CI 1.002-1.076), psychiatric pharmacotherapy (OR = 25.819, CI 11.465-58.143), and COVID infection (OR = 2.783, CI 1.215-6.372) were predictive of insomnia during the pandemic.CONCLUSIONS A considerable COVID-19 related psychosocial burden has been detected in RDs. Different factors were predictive of poor mental health and sleep disorders in these patients. Focused supportive strategies should be implemented to improve the psychological well-being of fragile patients during pandemics.
A New Strategy for Canine Visceral Leishmaniasis Diagnosis Based on Molecular Spectroscopy and Machine Learning
Authors: Larios Gustavo , Ribeiro Matheus , Arruda Carla , Oliveira Samuel L. , Canassa Thalita , Baker Matthew J. , Marangoni Bruno , Ramos Carlos , Cena Cícero 
Published: April 2021

Abstract
Visceral leishmaniasis is a neglected disease caused by protozoan parasites of the genus Leishmania. The successful control of the disease depends on its accurate and early diagnosis, which is usually made by combining clinical symptoms with laboratory tests such as serological, parasitological, and molecular tests. However, early diagnosis based on serological tests may exhibit low accuracy due to lack of specificity caused by cross-reactivities with other pathogens, and sensitivity issues related, among other reasons, to disease stage, leading to misdiagnosis. In this work was investigated the use of mid-infrared spectroscopy and multivariate analysis to perform a fast, accurate and easy canine visceral leishmaniasis diagnosis. Canine blood sera of non-infected, Leishmania infantum, and Trypanosoma evansi infected groups were studied. The data demonstrate that principal component analysis with machine learning algorithms achieved an overall accuracy above 85% in the diagnosis.
Local characterization of the Covid19 Response in low-income country: The case of a Lockdown in Zambia
Authors: Muzyamba Choolwe 
Published: April 2021

Abstract
Background The onset of the covid19 pandemic has sparked heated debate among scholars on the relevance of lockdowns. There are those in favor of the lockdown and others who are critical of it. However, despite the increased interest in understanding the relevance of lockdowns, there still has not been much focus on its relevance in low income countries like Zambia. Thus with the help of the SRT, we set out to explore and document the local characterization of the lockdown by residents of Lusaka, Zambia.Methods A qualitative study in the form of interviews was conducted in Lusaka, Zambia involving a sample of 68 participants. Due to the lockdown measures that were in place during the study, the interviews were conducted via phone calls and the data collected were later analyzed by use of thematic analysis technique.Results The lockdown was on one hand lauded for slowing down the incidence rates, preventing fatalities, and for protecting the healthcare system from collapse. On the other hand, it was criticized for exacerbating poverty levels, unemployment rates, increasing the rate of mental health problems, aiding gender based violence, and intensifying political repression and corruption. The results speak to the complexity in the characterization of the lockdown as a response to covid19 in Zambia. This observation demonstrates the folly of viewing, applying and characterizing the covid19 lockdown as a ‘one-size-fits-all’ approach in Zambia.Conclusion Thus rather than definitely establishing the lockdown as an incontestable good, as it is depicted by some scholars or as useless by its critics, our findings instead demonstrate the diversity and complexity in how it is locally viewed by Zambians. The study provides grounds for caution on simplistic and binary characterization of lockdowns. It indicates the need for careful dialog between the designers of lockdowns and citizens in order to tailor such interventions to local realities in context-specific ways. It also shows that though the development of such interventions, all the various and complex elements it embodies must be taken into account in order to realize optimum outcomes.
Graphene Oxide–Polymer Hydrogel: Wettability and Sound Absorption
Authors: Khosrozadeh A. , Rasuli R. , Hamzeloopak H. , Abedini Y. 
Published: April 2021

Abstract
In this paper, we introduce a nanocomposite as a humidity-sensitive sound absorber. The nanocomposites were prepared using hydrogel polymer (HP) as a matrix and graphene oxide (GO) as a filler. Results show that the surface energy of the nanocomposite is 58.4 mJm-2, and GO sheets increase the nanocomposite porosity from 2.6716 cm2 g-1 (for HP) up to 3.246 cm2 g-1. In addition, the diameter of nanocomposite pores is 8.5202 nm lower than that of HP (10.274 nm). To study the effect of humidity on the sound absorption, we exposed them to moisture for 30 and 60 min and then measured sound absorption. Results show an absorption peak for the HP at 1022 Hz with an attenuation value of 30%, while nanocomposite shows two main peaks around 1898 and 3300 Hz. In addition, results show that sound absorption peaks shift to higher frequency according to humidification time.
Improvement of Ligand-Free Modification Strategy: How to Obtain Water-Stable Up-Converting Nanoparticles With Bright Emission and High Reaction Yield?
Authors: Jurga Natalia , Przybylska Dominika , Kamiński Piotr , Grzyb Tomasz 
Published: April 2021

Abstract
Water-dispersible up-converting nanoparticles (UCNPs) are known to be very effective in biomedical applications. Research groups have paid special attention to the synthesis of hydrophilic UCNPs with good physicochemical properties. Being aware of this, we decided to improve the ligand-free modification method of OA-capped NaYF4:Yb3+,Er3+/NaYF4 UCNPs prepared by precipitation in high-boiling-point solvents as the thus-far reported methods do not provide satisfactory results. Different molarities of hydrochloric acid and various mixing times were selected to remove the organic ligand from the NPs’ surface and to discover the most promising modification approach. Highly water-stable colloids were obtained with a very high reaction yield of up to 96%. Moreover, the acid treatment did not affect the morphology and the size of the product. All of the crystals exhibited a bright up-conversion emission under 975-nm excitation, which confirmed the two-photon excitation and effective energy transfer between the used dopant ions. Thus, we could establish the most successful ligand-free modification procedure.
A novel 2 bp deletion variant in Ovine-DRB1 gene is associated with increased Visna/maedi susceptibility in Turkish sheep
Authors: Yaman Yalçın , Bay Veysel , Aymaz Ramazan , Keleş Murat , Öner Yasemin , Teferedegn Eden Yitna , Ün Cemal 
Published: April 2021

Abstract
Visna/Maedi (VM) is a multisystemic lentivirus infection of sheep that affecting sheep industry across the globe. TMEM154 gene has been identified to be a major VM associated host gene, nevertheless, a recent study showed that the frequency of the VM-resistant TMEM154 haplotypes was very low or absent in indigenous sheep. Thus, the present study was designed to determine other possible co-receptors associated with VM. For this purpose, DRB1 gene, which is renowned for its role in host immune response activity against various diseases was targeted. A total number of 151 case-control matched pairs were constructed from 2266 ELISA tested sheep. A broad range of DRB1 haplotype diversity was detected by sequence-based genotyping. Moreover, a novel 2 bp deletion (del) in the DRB1 intron 1 was identified. For final statistic, the sheep carrying VM-resistant TMEM154 diplotypes were removed and a McNemar’s test with a matched pairs experimental design was conducted. Consequently, it was identified for the first time that the 2 bp del variant is a genetic risk factor for VM (p-value, 0.002; chi-square, 9.3; odds ratio, 2.9; statistical power > 0.93) in dominant model. Thus, negative selection for 2 bp del variant could decrease VM infection risk in Turkish sheep.
Genetic Mapping of the Tomato Quality Traits Brix and Blossom-end Rot Under Supplemental LED and HPS Lighting Conditions
Authors: Prinzenberg Aina , Schoot Hanneke van der , Visser Richard GF , Marcelis Leo , Heuvelink Ep , Schouten Henk J 
Published: April 2021

Abstract
LED lighting has emerged as alternative to the current HPS standard in greenhouse production. However little is known about the impact on fruit quality under the different light spectra. We grew a biparental tomato RIL population between September 2019 and January 2020 under two commercial greenhouse supplemental lighting conditions, i.e. HPS, and 95% red/ 5% blue- LED, of about 220 µmol m− 2 s− 1 at maximum canopy height for 16h per day. Differences in Brix and blossom-end rot (BER) between the two light conditions were observed and we studied the genetic influences on those traits, separating genetics located on chromosomes from genetics located in plastids. The Brix value was on average 11% lower under LED than under HPS supplemental lighting. A LED-light specific QTL for Brix was identified on chromosome 6. This QTL can be of interest for breeding for tomato varieties cultivated under LED supplemental lighting. A Brix-QTL on chromosome 2 was found for both light conditions. In our study fewer plants developed BER under LED supplemental lighting than under HPS. We identified a novel genetic locus on chromosome 11 for the incidence of BER that lead to a difference in about 20% of fruits with BER. This genetic component was independent of the light.
Use of A Community of Practice For The Implementation of Evidence-Based Practices For Heart Failure Within The United States Department of Veterans Affairs
Authors: Sahay Anju , Heidenreich Paul A. , Mittman Brian S , Gholami Parisa , Lin Shoutzu 
Published: April 2021

Abstract
Communities of Practice (CoPs) are a promising approach to facilitate the implementation of evidence-based practices (EBPs) to improve care for chronic conditions like heart failure (HF). COPs involve a complex process of acquiring and converting both explicit and tacit knowledge into clinical activities. Formation: In July 2006, a CoP called the Heart Failure Provider Network (HF Network) was established in the United States (US) Department of Veterans Affairs (VA) with the overarching goal of improving the quality of care for HF patients. The CoP has involved a total of 1,341 multidisciplinary and multilevel members at all 144 VA Health Care Systems (sites). Examples of CoP activities include discussions of interventions to decrease hospitalization rates and to empower patients and caregivers for self-management. Goals of the CoP include networking facilitation, information dissemination and exchange, collaboration and implementation of EBPs. Assessment: We conceptualized the assessment (formative evaluation) of the HF Network in terms of its various activities (inputs) and proximal impacts (mediators) at the individual-level, and its distal and ultimate impacts (outcomes) at the site-level leading to an improved culture of implementation of new/improved EBPs at the system-wide level. The HF Network membership grew steadily over the nine years. Most members were practicing clinicians (n = 891, 66.4%), followed by administrators (n = 342, 25.5%), researchers (n = 70, 5.2%), and others (n = 38, 2.8%). Participation was “active” for 70.9% versus “passive” for 29.4% of members. The distribution of active members (clinicians 64.7%, administrators 21.6%) was similar to the distribution of overall membership. Survey respondents perceived the HF Network as useful in terms of its varied activities and resources relevant for patient care. Members, particularly those that consider themselves influential in improving quality of care, noted multiple benefits of membership. These included confirmation of one’s own clinical practices, evidence-based changes to their practice and help in understanding facilitators and barriers in setting up or running HF clinics and other programs.
Approximate Solutions of the Space-Fractional Diffusion Equations with Additive Noise
Authors: Mohammed Wael W. , Ahmad Hijaz 
Published: April 2021

Abstract
In this article we take into account a class of stochastic space diffusion equations with polynomials forced by additive noise. We derive rigorously limiting equations which de…ne the critical dynamics. Also, we approximate solutions of stochastic fractional space di¤usion equations with polynomial term by limiting equations, which are ordinary di¤er-ential equations. Moreover, we address the e¤ect of the noise on the solution’s stabilization. Finally, we apply our results to Fisher’s equation and Ginzburg–Landau models.
Differentiating Brucella Spondylitis from Tuberculous Spondylitis by the Conventional MRI and MR T2 Mapping: A Prospective Study
Authors: Guo Hui , Lan Siqin , He Yuanlin , Tiheiran Maijudan , Liu Wenya 
Published: April 2021

Abstract
Background Brucellar spondylitis (BS) and tuberculous spondylitis (TS) which cause initial bacteremia and show granulomatous lesions are the two leading types of spinal inflammatory. BS is easy to miss or maybe misdiagnosed as TS. Our purpose differentiates brucella spondylitis (BS) from tuberculous spondylitis (TS) in conventional MR imaging and MR T2 mapping.Methods We performed on 26 BS and 27 TS patients in conventional MR imaging and MR T2 mapping. We analyzed the features in conventional MR imaging and also measured T2 values of the lesion vertebrae (LV) and unaffected adjacent vertebrae (UAV) in BS and TS patients, respectively.Results There were no significant differences in sex, age, national between BS and TS. It was significantly lower of the severe vertebral destruction, vertebral posterior convex deformity, dead bone, and abscess scope in BS when compared to TS (p < 0.001, p = 0.005, p = 0.048, p < 0.001, p < 0.001, respectively). The vertebral hyperplasia was significantly higher in BS when compared to TS (p < 0.001). The T2 value of the LV with BS was markedly higher than that in the UAV with BS and that in the LV and UAV with TS (p < 0.001, p < 0.037, p < 0.001, respectively). The T2 value of the LV with TS was significantly higher than that of the UAV in TS and BS (p < 0.001, p < 0.001, respectively). There were no significant differences in the T2 value of the UAV between BS and TS (P = 0.568). Conclusions The qualitative and quantitative evaluation may differentiate BS from TS. The conventional MR imaging helps to distinguish BS from TS by several distinctive features. MR T2 mapping has the additional potential to provide quantitative information between BS and TS.