bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. Adults
Authors: Nikolovski Janeta , Koldijk Martin , Weverling Gerrit Jan , Spertus John , Turakhia Mintu , Saxon Leslie , Gibson Mike , Whang John , Sarich Troy , Zambon Bob , Ezeanochie Nnamdi , Turgiss Jennifer , Jones Robyn , Stoddard Jeff , Burton Paul , Navar Ann Marie 
Published: January 2021

AbstractBACKGROUNDThe success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake of immunization and highlights the importance of understanding factors associated with willingness to receive a vaccine.METHODSAdults enrolled in the Heartline™ clinical study were invited to complete a COVID-19 vaccine assessment through the Heartline™ mobile application between November 6-20, 2020. Factors associated with willingness to receive a COVID-19 vaccine were evaluated using an ordered logistic regression as well as a Random Forest classification algorithm.RESULTSAmong 9,106 study participants, 81.3% (n=7402) responded and had available demographic data. The majority (91.3%) reported a willingness to be vaccinated. Factors most strongly associated with vaccine willingness were beliefs about the safety and efficacy of COVID-19 vaccines and vaccines in general. Women and Black or African American respondents reported lower willingness to vaccinate. Among those less willing to get vaccinated, 66.2% said that they would talk with their health provider before making a decision. During the study, positive results from the first COVID-19 vaccine outcome study were released; vaccine willingness increased after this report.CONCLUSIONSEven among older adults at high-risk for COVID-19 complications who are participating in a longitudinal clinical study, 1 in 11 reported lack of willingness to receive COVID-19 vaccine in November 2020. Variability in vaccine willingness by gender, race, education, and income suggests the potential for uneven vaccine uptake. Education by health providers directed toward assuaging concerns about vaccine safety and efficacy can help improve vaccine acceptance among those less willing.Clinicaltrials.govNCT04276441
Debiasing Covid-19 prevalence estimates
Authors: Georganas Sotiris , Velias Alina , Vandoros Sotiris 
Published: January 2021

AbstractTimely, accurate epidemic figures are necessary for informed policy. In the Covid-19 pandemic, mismeasurement can lead to tremendous waste, in health or economic output. “Random” testing is commonly used to estimate virus prevalence, reporting daily positivity rates. However, since testing is necessarily voluntary, all “random” tests done in the field suffer fromselection bias. This bias, unlike standard polling biases, goes beyond demographical representativeness and cannot be corrected by oversampling (i.e. selecting people without symptoms to test). Using controlled, incentivized experiments on a sample of all ages, we show that people who feel symptoms are up to 33 times more likely to seek testing. The bias in testing propensities leads to sizable prevalence bias: test positivity is inflated by up to five times, even if testing is costless. This effect varies greatly across time and age groups, making comparisons over time and across countries misleading. We validate our results using the REACT study in the UK and find that positivity figures have indeed a very large and time varying bias. We present calculations to debias positivity rates, but importantly, suggest a parsimonious way to sample the population bypassing the bias altogether. Our estimation is both real-time and consistently close to true values. These results are relevant for all epidemics, besides covid-19, when carriers have informative beliefs about their own status.
Genetic diversity, distribution and domestication history of the neglected GGAtAtgenepool of wheat
Authors: Badaeva Ekaterina D. , Konovalov Fedor A. , Knüpffer Helmut , Fricano Agostino , Ruban Alevtina S. , Kehel Zakaria , Zoshchuk Svyatoslav A. , Surzhikov Sergei A. , Neumann Kerstin , Graner Andreas , Hammer Karl , Filatenko Anna , Bogaard Amy , Jones Glynis , Özkan Hakan , Kilian Benjamin 
Published: January 2021

AbstractWheat yields are stagnating around the world and new sources of genes for resistance or tolerances to abiotic traits are required. In this context, the tetraploid wheat wild relatives are among the key candidates for wheat improvement. Despite of its potential huge value for wheat breeding, the tetraploid GGAtAtgenepool is largely neglected. Understanding the population structure, native distribution range, intraspecific variation of the entire tetraploid GGAtAtgenepool and its domestication history would further its use for wheat improvement. We report the first comprehensive survey of genomic and cytogenetic diversity sampling the full breadth and depth of the tetraploid GGAtAtgenepool. We show that the extant GGAtAtgenepool consists of three distinct lineages. We provide detailed insights into the cytogenetic composition of GGAtAtwheats, revealed group-, and population-specific markers and show that chromosomal rearrangements play an important role in intraspecific diversity ofT. araraticum. We discuss the origin and domestication history of the GGAtAtlineages in the context of state-of-the-art archaeobotanical finds. We shed new light on the complex evolutionary history of the GGAtAtwheat genepool. We provide the basis for an increased use of the GGAtAtwheat genepool for wheat improvement. The findings have implications for our understanding of the origins of agriculture in southwest Asia.
Mobilization of antibiotic resistance genes differ by resistance mechanism
Authors: Nielsen Tue Kjærgaard , Browne Patrick Denis , Hansen Lars Hestbjerg 
Published: January 2021

AbstractThe degree to which antibiotic resistance genes (ARGs) are mobilized by insertion sequence (IS) elements, plasmids, and integrons has a strong association with their likelihood to function as resistance determinants. This stems from genetic decontextualization where strong promoters often present in IS elements and integrons and the copy number effect of plasmids contribute to high expression of accessory genes. Here, we screen all complete bacterial RefSeq genomes for ARGs. The genetic contexts of detected ARGs are investigated for IS elements, integrons, plasmids, and phylogenetic dispersion. The ARG-MOB scale is proposed which indicates how mobilized detected ARGs are in bacterial genomes. Antibiotic efflux genes are rarely mobilized and it is concluded that these are often housekeeping genes that are not decontextualized to confer resistance through overexpression. Even 80% of β-lactamases have never, or very rarely, been mobilized in the 15,790 studied genomes. However, some ARGs are indeed mobilized and co-occur with IS elements, plasmids, and integrons. These results have consequences for the design and interpretation of studies screening for resistance determinants, as mobilized ARGs pose a more concrete risk to human health, especially under heterologous expression, than groups of ARGs that have only been shown to confer resistance in cloning experiments.
Temporal order of mutations influences cancer initiation dynamics
Authors: Teimouri Hamid , Kolomeisky Anatoly B. 
Published: January 2021

AbstractCancer is a set of genetic diseases that are driven by mutations. It was recently discovered that the temporal order of genetic mutations affects the cancer evolution and even the nature of the decease itself. The mechanistic origin of these observations, however, remain not well understood. Here we present a theoretical model for cancer initiation dynamics that allows us to quantify the impact of the temporal order of mutations. In our approach, the cancer initiation process is viewed as a set of stochastic transitions between discrete states defined by the different numbers of mutated cells. Using a first-passage analysis, probabilities and times before the cancer initiation are explicitly evaluated for two alternative sequences of two mutations. It is found that the probability of cancer initiation is determined only by the first mutation, while the dynamics is specified by both mutations. In addition, it is shown that the acquisition of a mutation with higher fitness before mutation with lower fitness increases the probability of the tumor formation but delays the cancer initiation. Theoretical results are explained using effective free-energy landscapes.
COT: an efficient Python tool for detecting marker genes among many subtypes
Authors: Lu Yingzhou , Wu Chiung-Ting , Parker Sarah J. , Chen Lulu , Saylor Georgia , Van Eyk Jennifer E. , Herrington David M. , Wang Yue 
Published: January 2021

AbstractWe develop an accurate and efficient method to detect marker genes among many subtypes using subtype-enriched expression profiles. We implement a Cosine based One-sample Test (COT) Python software that is easy to use and applicable to multi-omics data. We demonstrate the performance and utility of COT on gene expression and proteomics data acquired from tissue or cell subtypes. Formulated as a one-sample test with Cosine similarity test statistic in scatter space, the detected de novo marker genes will allow biologists to perform a more comprehensive and unbiased molecular characterization, deconvolution and classification of complex tissue or cell subtypes.
The sensitivity of third party punishment to the framing effect and its brain mechanism
Authors: Yang Jiamiao , Liu Jie , Gu Ruolei , Deng Kexin , Huang Xiaoxuan , Cui Fang 
Published: January 2021

AbstractPeople as third-party observers, without direct self-interest, may punish norm violators to maintain social norms. However, third-party judgment and the follow-up punishment might be susceptible to the way we frame (i.e., verbally describe) a norm violation. We conducted a behavioral and a neuroimaging experiment to investigate the above phenomenon, which we call “third-party framing effect.” In these experiments, participants observed an anonymous player A decided whether to retain her/his economic benefit while exposing player B to a risk of physical pain (described as “harming others” in one condition and “not helping others” in the other condition), then they had a chance to punish player A at their own cost. Participants were more willing to execute third-party punishment under theharmframe compared to thehelpframe, manifesting as a framing effect. Self-reported moral outrage toward player A mediated the relationship between empathy toward player B and the framing effect size. Correspondingly, the insula (possibly related to empathy) and cerebellum (possibly related to anger) were activated more strongly under theharmframe than thehelpframe. Functional connectivity between these regions showed strongest weight when predicting the framing effect size. These findings shed light on the psychological and neural mechanisms of the third-party framing effect.Graphic abstract
The PELOTA-HBS1 Complex Orchestrates mRNA Translation Surveillance and PDK1-mediated Plant Growth and Development
Authors: Kong Wei , Tan Shutang , Zhao Qing , Lin De-Li , Xu Zhi-Hong , Friml Jiří , Xue Hong-Wei 
Published: January 2021

AbstractThe quality control system for messenger RNA is fundamental for cellular activities in eukaryotes. To elucidate the molecular mechanism of 3’-Phosphoinositide-Dependent Protein Kinase1 (PDK1), an essential regulator throughout growth and development of eukaryotes, a forward genetic approach was employed to screen for suppressors of the loss-of-function T-DNA insertionalpdk1.1 pdk1.2double mutant inArabidopsis. Notably, the severe growth attenuation ofpdk1.1 pdk1.2is rescued bysop21(suppressorofpdk1.1 pdk1.2) that harbours a loss-of-function mutation inPELOTA1(PEL1). PEL1 is a homologue of mammalian PELOTA and yeast DOM34, which form a heterodimeric complex with the GTPase HBS1, responsible for ribosome rescue to assure the quality and fidelity of mRNA molecules. Genetic analysis further reveals that the dysfunction of PEL1-HBS complex fails to degrade the T-DNA-disrupted, truncated but functional PDK1 transcripts, thus rescuingpdk1.1 pdk1.2. Our studies demonstrate the functionality and identify the essential functions of a homologous PELOTA-HBS1 complex in higher plant, and provide novel insights into the mRNA quality control mechanism.
Self-aided SINS for spiral-diving human-occupied vehicle in midwater
Authors: Liu Xianjun , Liu Xixiang , Shen Hang , Li Peijuan , Zhang Tongwei 
Published: January 2021

Purpose
Motivated by the problems that the positioning error of strap-down inertial navigation system (SINS) accumulates over time and few sensors are available for midwater navigation, this paper aims to propose a self-aided SINS scheme for the spiral-diving human-occupied vehicle (HOV) based on the characteristics of maneuvering pattern and SINS error propagation.

Design/methodology/approach
First, the navigation equations of SINS are simultaneously executed twice with the same inertial measurement unit (IMU) data as input to obtain two sets of SINS. Then, to deal with the horizontal velocity provided by one SINS, a delay-correction high-pass filter without phase shift and amplitude attenuation is designed. Finally, the horizontal velocity after processing is used to integrate with other SINS.

Findings
Simulation results indicate that the horizontal positioning error of the proposed scheme is less than 0.1 m when an HOV executes spiral diving to 7,000 meters under the sea and it is inherently able to estimate significant sensors biases.

Originality/value
The proposed scheme can provide a precise navigation solution without error growth for spiral-diving HOV on the condition that only IMU is required as a navigation sensor.
Antecedents of smartphone brand switching: a push–pull–mooring framework
Authors: Liao Junyun , Li Muhua , Wei Haiying , Tong Zelin 
Published: January 2021

PurposeRecent years have witnessed the increasingly fierce competition amongst smartphone brands. Hence, smartphone firms urge to prevent current consumers from switching to maintain market position. Based on the push–pull–mooring (PPM) framework, this study aims to explore the drivers of users' intentions to switch from their current smartphone brands.Design/methodology/approachBased on previous literature and the characteristics of the smartphone purchase, this study identified one pushing, two pulling and five mooring factors. Online questionnaires were collected to test hypotheses using the structural equation modelling approach. An additional netnography study provides further support to the hypotheses.FindingsResults show that regret is a push factor that enhances consumers' switching intentions. Moreover, two pull factors, subjective norms and alternative attractiveness positively influence consumers' switching intentions. Finally, switching costs, emotional commitment and brand community engagement are mooring factors that negatively affect brand-switching intention, whereas consumers' variety seeking has a positive effect.Originality/valueThis study enriches the brand switching literature and offers significant implications for customer retention.
Prioritising water disinfection technologies to improve food safety of leafy vegetables
Authors: van Asselt E.D. , Banach J.L. , Klüche M. , Appelman W.A.J. 
Published: January 2021

PurposeLeafy vegetables may get contaminated with pathogens through the use of irrigation water during open field cultivation. The main control option to prevent this contamination is the use of disinfection technologies that will reduce the pathogenic load of the irrigation water. Several technologies, either chemical or physical, are available for disinfection, which were gathered from the literature and European Union (EU) projects. The purpose of this paper is to prioritise these technologies.Design/methodology/approachA feasibility study was performed to identify the most promising disinfection technology considering 12 different criteria. A two-tier approach was used in which the technologies were first evaluated based on three criteria: legal status, effectiveness and technology readiness level (TRL). Only the technologies that reached pre-set thresholds for these three criteria were then evaluated in the second tier.FindingsThe evaluation showed that the most promising technologies after the tier-2 evaluation were ultrasound, microfiltration, ultraviolet and ozone. The study showed that the followed approach enabled prioritising disinfection technologies allowing for selecting the most promising technologies that can be tested further on a possible application during primary production to prevent possible food safety issues in leafy vegetables.Research limitations/implicationsThe overview is not an exhaustive list of disinfection technologies available rather only those technologies that seemed promising for application in horticulture were addressed. Some technologies may, thus, have been missed. Nevertheless, a total of 12 single and seven combined technologies were evaluated.Originality/valueThis is the first study that uses a structured approach to prioritise a broad range of possible water disinfection technologies for use at primary production.
Patient-centered communication: an extension of the HCAHPS survey
Authors: Islam Shahidul , Muhamad Nazlida 
Published: January 2021

PurposeThe Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) has been recognized as a “gold standard” set of “practical standardized measures” for assessing hospital service quality. Beginning with the HCAHPS, the purpose of this paper is to extend efforts to assess patient-centered communication (PCC) and the quality of healthcare and presents a scale for measuring patient perceptions and expectations of service quality in an emerging economy context.Design/methodology/approachA self-administered survey of patients in private hospitals (N = 171) was conducted to test the proposed framework. Exploratory and confirmatory factor analyses were used to establish the measurement model. Multiple regression analysis was used to explain the scale's predictive ability. ANOVA was used to analyze service quality gaps and rank patients' priorities.FindingsFive components of PCC are identified. Among these, nurse affective communication has a significant positive effect on patient satisfaction. The gap analysis shows that patients have high expectations for doctors' affective communication, while they perceive a low level of service performance in the realm of nurse affective communication. The study highlights a new means of measuring “reliability” in healthcare. Important findings on patients' priorities are evaluated and discussed.Practical implicationsHealthcare organizations and practitioners can improve patient-centered care by stressing the dimensions of PCC, including clinicians' affective and instrumental communication.Originality/valueThe study expands the understanding of HCAHPS instruments in an emerging economy context and opens avenues for more widespread use of the measures. The research contributes to the literature on patient-centered care and healthcare service quality by proposing a scale for managing specific practices and interactions in healthcare.
Rural minimum living standard guarantee (rural Dibao) program boosts children's education outcomes in rural China
Authors: He Zixuan , Fang Xiangming , Rose Nathan , Zheng Xiaodong , Rozelle Scott 
Published: January 2021

PurposeTo combat poverty in China's rural areas, Chinese government has established an unconditional cash transfer program known as the Rural Minimum Living Standard Guarantee (Rural Dibao) Program. Interestingly, despite the importance of education in breaking cycles of poverty, little is known about Rural Dibao's impact on rural children's education. This study investigates Rural Dibao's impact on rural children's learning outcomes by first examining targeting issues within the program, exploring a causal relationship between Rural Dibao and learning outcomes, and then exploring potential mechanisms and heterogeneous effects.Design/methodology/approachFixed effects model and propensity score weighting method and data from China Family Panel Studies (CFPS) from the years 2010 and 2014 were used.FindingsThe results suggest that the Rural Dibao program suffers from high levels of targeting error, yet is still effective (i.e., program transfers generally still go to people in need). The fixed effects and propensity score weighting models find that program participation raises rural children's standardized test scores in CFPS Chinese-language and math tests. In investigating mechanisms, increased education expenditure seems to connect Rural Dibao participation to increased learning results. The heterogeneity analysis shows that poorer, non-eastern, not left behind, younger or male children benefit from the program (while others have no effect).Originality/valueThese findings suggest that Rural Dibao participation boosts rural children's learning, which could indicate a long-term anti-poverty effect, and that if the program can resolve targeting problems, this effect could be even greater.
China's outward foreign direct investment and bilateral export sophistication: a cross countries panel data analysis
Authors: Rehman Faheem Ur , Noman Abul Ala 
Published: January 2021

PurposeChina's outward foreign direct investment (OFDI) has risen remarkably over the past two decades. Does such increase affect the sophistication of Chinese exports, is a significant issue that has surprisingly remained unaddressed? The purpose of this study is to investigate the impact of Chinese OFDI on bilateral export sophistication of China and its OFDI receiving partner countries during 2003–2017 by applying Poisson pseudo-maximum likelihood approach based on gravity model.Design/methodology/approachThe analysis has been performed for total sample, region-wise grouped sample (Europe and Central Asia, Middle East and North Africa, Latin America and Caribbean, East Asia and Pacific, South Asia, North America and sub-Saharan Africa) and income-wise grouped sample (high income, upper middle income, lower middle income and lower income group sample).FindingsThe results confirmed the significant and positive effect of Chinese OFDI on bilateral export sophistication in total sample, regions-wise and income groups sample.Originality/valueThe study provides a helpful suggestion regarding policy towards achieving more sophistication in export and thus to achieve comparative advantage in trade.