bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized, open-label, parallel, multi-center Phase IV study to compare the efficacy and safety of atorvastatin 10 and 20 mg in high-risk Asian patients with hypercholesterolemia
Authors: Kim Ji Bak , Song Woo Hyuk , Park Jong Sung , Youn Tae-Jin , Park Yong Hyun , Kim Shin-Jae , Ahn Sung Gyun , Doh Joon-Hyung , Cho Yun-Hyeong , Kim Jin Won 
Published: January 2021

BackgroundAlthough accumulating evidence suggests a more extensive reduction of low-density lipoprotein cholesterol (LDL-C), it is unclear whether a higher statin dose is more effective and cost-effective in the Asian population. This study compared the efficacy, safety, and cost-effectiveness of atorvastatin 20 and 10 mg in high-risk Asian patients with hypercholesterolemia.MethodsA 12-week, open-label, parallel, multicenter, Phase IV randomized controlled trial was conducted at ten hospitals in the Republic of Korea between October 2017 and May 2019. High-risk patients with hypercholesterolemia, defined according to 2015 Korean guidelines for dyslipidemia management, were eligible to participate. We randomly assigned 250 patients at risk of atherosclerotic cardiovascular disease to receive 20 mg (n = 124) or 10 mg (n = 126) of atorvastatin. The primary endpoint was the difference in the mean percentage change in LDL-C levels from baseline after 12 weeks. Cost-effectiveness was measured as an exploratory endpoint.ResultsLDL-C levels were reduced more significantly by atorvastatin 20 mg than by 10 mg after 12 weeks (42.4% vs. 33.5%, p < 0.0001). Significantly more patients achieved target LDL-C levels (<100 mg/dL for high-risk patients, <70 mg/dL for very high-risk patients) with atorvastatin 20 mg than with 10 mg (40.3% vs. 25.6%, p < 0.05). Apolipoprotein B decreased significantly with atorvastatin 20mg versus 10 mg (−36.2% vs. −29.9%, p < 0.05). Lipid ratios also showed greater improvement with atorvastatin 20 mg than with 10 mg (total cholesterol/high-density lipoprotein cholesterol ratio, −33.3% vs. −29.4%, p < 0.05; apolipoprotein B/apolipoprotein A1 ratio, −36.7% vs. −31.4%, p < 0.05). Atorvastatin 20 mg was more cost-effective than atorvastatin 10 mg in terms of both the average and incremental cost-effectiveness ratios. Safety and tolerability of atorvastatin 20 mg were comparable to those of atorvastatin 10 mg.ConclusionIn high-risk Asian patients with hypercholesterolemia, atorvastatin 20 mg was both efficacious in reducing LDL-C and cost-effective compared with atorvastatin 10 mg.
The association between physical complications following female genital cutting and the mental health of 12-year-old Gambian girls: A community-based cross-sectional study
Authors: Bendiksen Bothild , Heir Trond , Minteh Fabakary , Ziyada Mai Mahgoub , Kuye Rex A. , Lien Inger-Lise 
Published: January 2021

Background
Female genital cutting (FGC) involve an acute physical trauma that hold a potential risk for immediate and long-term complications and mental health problems. The aim of this study was to examine the prediction of depressive symptoms and psychological distress by the immediate and current physical complications following FGC. Further, to examine whether the age at which 12-year-old Gambian girls had undergone the procedure affected mental health outcomes.

Method
This cross-sectional study recruited 134 12-year-old girls from 23 public primary schools in The Gambia. We used a structured clinical interview to assess mental health and life satisfaction, including the Short Mood and Feeling Questionnaire (SMFQ), the Symptom check list (SCL-5) and Cantril’s Ladder of Life Satisfaction. Each interview included questions about the cutting procedure, immediate- and current physical complications and the kind of help and care girls received following FGC.

Results
Depressive symptoms were associated with immediate physical health complications in a multivariate regression model [RR = 1.08 (1.03, 1.12), p = .001], and with present urogenital problems [RR = 1.19 (1.09, 1.31), p < .001]. The girls that received medical help following immediate complications had a lower risk for depressive symptoms [RR = .73 (.55, .98), p = .04]. Psychological distress was only associated with immediate complications [RR = 1.04 (1.01, 1.07), p = .004]. No significant differences in mental health outcomes were found between girls who underwent FGC before the age of four in comparison to girls who underwent FGC after the age of four.

Conclusion
Our findings indicate that the immediate and long-term complications following FGC have implications for psychological health. Only a minimal number of girls received medical care when needed, and the dissemination of health education seems crucial in order to prevent adverse long-term physical and psychological health consequences.
A novel procalcitonin-based score for detecting sepsis among critically ill patients
Authors: Tsui Tung-Lin , Huang Ya-Ting , Kan Wei-Chih , Huang Mao-Sheng , Lai Min-Yu , Ueng Kwo-Chang , Shiao Chih-Chung 
Published: January 2021

Background
Procalcitonin (PCT) has been widely investigated as an infection biomarker. The study aimed to prove that serum PCT, combining with other relevant variables, has an even better sepsis-detecting ability in critically ill patients.

Methods
We conducted a retrospective cohort study in a regional teaching hospital enrolling eligible patients admitted to intensive care units (ICU) between July 1, 2016, and December 31, 2016, and followed them until March 31, 2017. The primary outcome measurement was the occurrence of sepsis. We used multivariate logistic regression analysis to determine the independent factors for sepsis and constructed a novel PCT-based score containing these factors. The area under the receiver operating characteristics curve (AUROC) was applied to evaluate sepsis-detecting abilities. Finally, we validated the score using a validation cohort.

Results
A total of 258 critically ill patients (70.9±16.3 years; 55.4% man) were enrolled in the derivation cohort and further subgrouped into the sepsis group (n = 115) and the non-sepsis group (n = 143). By using the multivariate logistic regression analysis, we disclosed five independent factors for detecting sepsis, namely, “serum PCT level,” “albumin level” and “neutrophil-lymphocyte ratio” at ICU admission, along with “diabetes mellitus,” and “with vasopressor.” We subsequently constructed a PCT-based score containing the five weighted factors. The PCT-based score performed well in detecting sepsis with the cut-points of 8 points (AUROC 0.80; 95% confidence interval (CI) 0.74–0.85; sensitivity 0.70; specificity 0.76), which was better than PCT alone, C-reactive protein and infection probability score. The findings were confirmed using an independent validation cohort (n = 72, 69.2±16.7 years, 62.5% men) (cut-point: 8 points; AUROC, 0.79; 95% CI 0.69–0.90; sensitivity 0.64; specificity 0.87).

Conclusions
We proposed a novel PCT-based score that performs better in detecting sepsis than serum PCT levels alone, C-reactive protein, and infection probability score.
HFpEF without elevated right ventricular systolic pressure is a favorable prognostic indicator in patients with IPF requiring hospitalization for heart failure
Authors: Yamazaki Ryo , Nishiyama Osamu , Yoshikawa Kazuya , Saeki Sho , Sano Hiroyuki , Iwanaga Takashi , Tohda Yuji 
Published: January 2021

Background
Some patients with idiopathic pulmonary fibrosis (IPF) must be hospitalized because of heart failure (HF), including HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF). The association between IPF and HF has not been clarified. We retrospectively investigated the clinical features and outcomes of patients with IPF who required nonelective hospitalization because of HF.

Methods
We examined data from IPF patients who required nonelective hospitalization for HF at the Kindai University Hospital from January 2008 to December 2018. We divided the patients into 3 groups: those with HFpEF without elevated right ventricular systolic pressure (RVSP), those with HFpEF and elevated RVSP, and those with HFrEF. The recurrence rates of HF after discharge and the 30- and 90-day mortality rates of the patients were evaluated.

Results
During the study period, 37 patients with IPF required hospitalization because of HF. Among the 34 patients included in the study, 17 (50.0%) were diagnosed with HFpEF without elevated RVSP, 11 (32.3%) with HFpEF and elevated RVSP, and 6 (17.6%) with HFrEF. Patients with HFrEF had significantly higher values for B-type natriuretic peptide (BNP) and left ventricular (LV) end-systolic and end-diastolic diameters than patients with the 2 types of HFpEF (BNP: P = 0.01 and P = 0.0004, LV end-systolic diameter: P <0.0001 and P <0.0001, and LV end-diastolic diameter: P = 0.01 and P = 0.0004, respectively). Notably, the difference between the LVEFs of the patients with 2 types of HFpEF was not significant. The patients with HFpEF without elevated RVSP had the lowest 30- and 90-day mortality rates (0%, P = 0.02 and 11.7%, P = 0.11, respectively).

Conclusions
Among patients with IPF, HFpEF without elevated RVSP was the most common type of HF that required hospitalization. Patients with HFpEF without elevated RVSP survived longer than the patients with the other 2 types of HF.
Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study
Authors: Goodacre Steve , Thomas Ben , Sutton Laura , Burnsall Matthew , Lee Ellen , Bradburn Mike , Loban Amanda , Waterhouse Simon , Simmonds Richard , Biggs Katie , Marincowitz Carl , Schutter Jose , Connelly Sarah , Sheldon Elena , Hall Jamie , Young Emma , Bentley Andrew , Challen Kirsty , Fitzsimmons Chris , Harris Tim , Lecky Fiona , Lee Andrew , Maconochie Ian , Walter Darren 
Published: January 2021

Objectives
We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely ill adults with suspected COVID-19 infection.

Methods
We undertook a mixed prospective and retrospective observational cohort study in 70 emergency departments across the United Kingdom (UK). We collected presenting data from 22445 people attending with suspected COVID-19 between 26 March 2020 and 28 May 2020. The primary outcome was death or organ support (respiratory, cardiovascular, or renal) by record review at 30 days. We split the cohort into derivation and validation sets, developed a clinical score based on the coefficients from multivariable analysis using the derivation set, and the estimated discriminant performance using the validation set.

Results
We analysed 11773 derivation and 9118 validation cases. Multivariable analysis identified that age, sex, respiratory rate, systolic blood pressure, oxygen saturation/inspired oxygen ratio, performance status, consciousness, history of renal impairment, and respiratory distress were retained in analyses restricted to the ten or fewer predictors. We used findings from multivariable analysis and clinical judgement to develop a score based on the NEWS2 score, age, sex, and performance status. This had a c-statistic of 0.80 (95% confidence interval 0.79–0.81) in the validation cohort and predicted adverse outcome with sensitivity 0.98 (0.97–0.98) and specificity 0.34 (0.34–0.35) for scores above four points.

Conclusion
A clinical score based on NEWS2, age, sex, and performance status predicts adverse outcome with good discrimination in adults with suspected COVID-19 and can be used to support decision-making in emergency care.

Registration
ISRCTN registry, ISRCTN28342533, http://www.isrctn.com/ISRCTN28342533
Development of aortic valve stenosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with renal involvement
Authors: Hasegawa Midori , Iwasaki Jin , Sugiyama Satoshi , Ishihara Takuma , Yamamoto Yoshihiro , Asada Hiroaki , Koide Shigehisa , Hayashi Hiroki , Takahashi Kazuo , Inaguma Daijo , Yuzawa Yukio , Tsuboi Naotake 
Published: January 2021

IntroductionDegenerative aortic valve stenosis (AS) is a chronic progressive disease that resembles atherosclerosis development. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is reportedly associated with accelerated atherosclerosis. This study aimed to examine the development of AS in patients with myeloperoxidase-AAV (MPO-AAV) with renal involvement at more than 1 year after the onset of vasculitis.MethodsWe performed a retrospective review of clinical records of MPO-AAV patients with renal involvement without AS at the onset of vasculitis who were treated in three hospitals and three dialysis clinics.ResultsThe study included 97 MPO-AAV patients with renal involvement and 230 control patients with chronic kidney disease (CKD). Among them, 64 patients had AS. The prevalence rates of AS were 28.9% and 15.7% in MPO-AAV and control patients, respectively (p = 0.006). The multivariable logistic regression analysis showed that MPO-AAV, dialysis dependence, and hypertension were independently associated factors for AS. In MPO-AAV patients, systolic blood pressure was positively significantly associated with AS, whereas glucocorticoid dose of induction therapy was negatively significantly associated. The use of cyclophosphamide tended to be negatively associated with AS. The survival rate was significantly lower for patients with AS than for those without AS.ConclusionsThe AS prevalence rate was significantly higher in MPO-AAV patients at more than 1 year after the onset of vasculitis than in control CKD patients. Therefore, regular monitoring of echocardiography during MPO-AAV treatment is suggested.
Henrietta Crawford: Radical Black Evangelist in Post-Civil War New Jersey
Authors: Johnson James Elton 
Published: January 2021

Representing Black feminisms of the so-called, “First Wave era of American feminism,” forgotten icon Henrietta Crawford impacted Black political representation in southern New Jersey during the post-Civil War decades. As a noted evangelist, universal suffragist, Black community organizer, Civil Rights activist, homemaker, and intergenerational caregiver for minor dependents, Crawford crafted an intersectional legacy worthy of commemorative re-remembrance. Collectively, scattered bits and pieces of information recorded over the past eighty years in newspapers and in recent scholarly accounts offer an incoherent combination of disparate hints at Henrietta’s historical significance. Buttressed, however, by historical insight, contemporary newspaper accounts, Civil War pension file records, real estate deed transactions, federal and state census records, vital statistics data, the evidentiary record sheds light on Crawford’s important role in the operation of historically significant Mt. Pisgah [U.A.M.E.] Church in Vineland and her associated development and implementation of important social justice initiatives. In 1948, a fifty-year commemorative notation about James and Henrietta Crawford’s 1898 departure from Vineland was published in the Daily Journal newspaper. Twenty-five years later “New Jersey Mother of the Year Award” recipient Rebecca Lassiter noted the Crawfords' important role in her life as foster parents. In year seventy-three since the Daily Journal’s acknowledgement, this essay conveys Henrietta Crawford’s legacy to students, scholars, and the general readership for current and future generations. As the present confluence of national political and economic crises resolves within an encapsulating global pandemic that is exacerbating socio-economic inequalities, Crawford’s life and record offers a critical example of faith-based social-justice activism and the seamless role of African American women in American history.
The President and the Plague
Authors: Riccards Michael P. 
Published: January 2021

Our “Research Notes” section was inaugurated to allow scholars to share their works in progress and solicit feedback from others in the NJ History community. All are welcome to contribute- simply send submissions for inclusion in future issues to the editor (mziobro@monmouth.edu). Beginning with our Winter 2021 issue, we are listing each note individually rather than in one document. In this note, Michael P. Riccards explores how Woodrow Wilson faced similar problems in 1918-1919 with that pandemic, and his response was very different from Donald Trump.
Photovoltaic system optimization by new maximum power point tracking (MPPT) models based on analog components under harsh condition
Authors: Hoang Minh Long 
Published: January 2021

Abstract
Photovoltaic (PV) energy has become a promising energy source because the demand for electrical energy from renewable energy sources is increasing worldwide in recent decades. Due to efficiency issues, the Maximum Power Point Tracking (MPPT) has been developed to optimize the solar panel’s performance. This paper presents an MPPT model, made up of the analog component, which overcomes traditional MPPT methods’ weakness via the Perturb and observes (P&O) technique. In this case, the PV system includes a PV array, a DC/DC boost converter, a battery, and a load. The proposed method was precisely built and simulated using the Powersim, MATLAB Simulink, and SimCoupler Module. The components of the analog MPPT system were designed practically in detail. The experiment was carried out by using European Efficiency Test 50530, and the results showed the proposed model has higher efficiency over the digital MPPT technique, about 99.99% as maximum. Moreover, MPPT methods were tested under steady-state, irradiation variation, and space conditions to verify the system’s potential capability with PV module Solbian 52L.
The twinned crystal structure of 1,3-phenylenedimethanaminium dibromide, C8H14Br2N2
Authors: Brandt Niklas , Reiss Guido J. 
Published: January 2021

Abstract
C8H14Br2N2, monoclinic, I2/a (no. 15), a = 9.0331(9) Å, b = 13.4475(14) Å, c = 27.586(3) Å, β = 94.879(9)°, Z = 12, V = 3338.8(6) Å3, R

gt
(F) = 0.0582, wR
ref = 0.0885, T = 290 K.
Co-Designing Visualizations for Information Seeking and Knowledge Management
Authors: Dörk Marian , Müller Boris , Stange Jan-Erik , Herseni Johannes , Dittrich Katja 
Published: January 2021

AbstractCreativity is a crucial factor in finding novel and useful visualization and interaction techniques, but its emergence is contingent on the right conditions. The focus of visualization research has traditionally been on techniques, and to a lesser degree on the process of creating them with domain experts and end users. This paper focuses on the collaborative design of visualizations for information seeking and knowledge management. The difficult, yet common challenge in any visualization project is to find meaningful visual representations and useful interaction techniques to carry out complex analysis tasks. The unique difficulty for preparing co-design activities for visualization lies in the gap between the abstract nature of data and the concrete form of visual representations. To bridge this gap, our co-design framework for visualization places particular emphasis on actors, activities, and artifacts as categories that expand the focus of visualization design beyond the traditional triad of users, tasks, and data. Drawing from general co-design principles, the framework is developed and validated during the course of two case studies in the context of information management systems and library collection databases. Based on observed patterns during the case studies, practical tactics provide advice on carrying out co-design in information visualization.
The tolerance to stretch is linked with endogenous modulation of pain
Authors: Støve Morten Pallisgaard , Hirata Rogerio Pessoto , Palsson Thorvaldur Skuli 
Published: January 2021

Abstract

Objectives
The effect of stretching on joint range of motion is well documented, and although sensory perception has significance for changes in the tolerance to stretch following stretching the underlining mechanisms responsible for these changes is insufficiently understood. The aim of this study was to examine the influence of endogenous pain inhibitory mechanisms on stretch tolerance and to investigate the relationship between range of motion and changes in pain sensitivity.

Methods
Nineteen healthy males participated in this randomized, repeated-measures crossover study, conducted on 2 separate days. Knee extension range of motion, passive resistive torque, and pressure pain thresholds were recorded before, after, and 10 min after each of four experimental conditions; (i) Exercise-induced hypoalgesia, (ii) two bouts of static stretching, (iii) resting, and (iv) a remote, painful stimulus induced by the cold pressor test.

Results
Exercise-induced hypoalgesia and cold pressor test caused an increase in range of motion (p<0.034) and pressure pain thresholds (p<0.027). Moderate correlations in pressure pain thresholds were found between exercise-induced hypoalgesia and static stretch (Rho>0.507, p=0.01) and exercise-induced hypoalgesia and the cold pressor test (Rho=0.562, p=0.01). A weak correlation in pressure pain thresholds and changes in range of motion were found following the cold pressor test (Rho=0.460, p=0.047). However, a potential carryover hypoalgesic effect may have affected the results of the static stretch.

Conclusions
These results suggest that stretch tolerance may be linked with endogenous modulation of pain. Present results suggest, that stretch tolerance may merely be a marker for pain sensitivity which may have clinical significance given that stretching is often prescribed in the rehabilitation of different musculoskeletal pain conditions where reduced endogenous pain inhibition is frequently seen.
Ambulante Notfallbehandlung in der Gesetzlichen Krankenversicherung – Eine empirische Analyse
Authors: Kopetsch Thomas , Steffen Laura 
Published: January 2021

Abstract
Reorganization of the office-based emergency care system is currently on the political agenda in Germany. Analysing the present situation, the present study makes an empirical comparison between usage of the office-based emergency service and of the competing hospital outpatient departments in different localities, also examining the possible reasons for the differences.
Family doctor density was found to have a negative influence on the number of cases in hospital outpatient departments and a positive influence on the number of cases dealt with by the emergency service of the office-based physicians. Further, the number of hospitals in a county correlates positively with the cases in hospital outpatient departments.
Ein Schuldenerlass als Ende mit Schrecken?
Authors: Hansen Arne , Meyer Dirk 
Published: January 2021

Abstract
The rising debt-to-GDP ratios of the eurozone member states result not least from the coronavirus crisis. Without external support, especially with regard to Italy, but also for other Mediterranean states, access to the capital market could be seriously threatened in the medium run. The recovery fund ‘Next Generation EU’ likely directs the fundamental structures of the European Union (EU) towards a fiscal union with considerable transfer elements, while the Pandemic Emergency Purchase Programme (PEPP), which is declared as a monetary policy instrument, is even discussed as a violation of the prohibition of monetary financing. As an alternative, this contribution analyses a debt relief by the European System of Central Banks (ESCB), implemented via an EU debt agency. This construction would avoid a negative equity position of the central banks and also enable a legal integration into the EU system. The question remains: What would be the consequences of such a non-recurring step?