bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five‐year observational study of Internet‐delivered cognitive behavioural pain management when offered as routine care by an online therapy clinic
Authors: Hadjistavropoulos Heather D. , Peynenburg Vanessa , Thiessen David , Schneider Luke H. , Nugent Marcie , Wilhelms Andrew , Karin Eyal , Titov Nickolai , Dear Blake F. 
Published: September 2021

AbstractBackgroundInternet‐delivered cognitive behavioural pain management programmes (PMPs) are effective, but less is known about their use outside of research trials. Five years of data from offering the Internet‐delivered cognitive behavioural PMP in an online therapy clinic was examined to assess effectiveness, acceptability and predictors of outcomes.MethodsPatients (N = 293) were offered a previously validated 8‐week Internet‐delivered cognitive behavioural PMP and administered measures at pre‐treatment, post‐treatment and 3 months.ResultsThere was growth in demand for an Internet‐delivered cognitive behavioural PMP over time (n = 64 first year to n = 133 fifth year). Moderate‐to‐large improvements on depression (post‐treatment 35% reduction; 3‐month 41% reduction) and anxiety (post‐treatment 37% reduction; 3‐month 41% reduction), and small‐to‐moderate improvements on disability (post‐treatment 19% reduction; 3‐month 20% reduction) were found. Lesson completion and satisfaction were high. Lower pain acceptance, lower pain self‐efficacy and higher pain intensity were associated with lower improvements on depression, anxiety and disability.ConclusionsThis longitudinal observational study provides support for Internet‐delivered cognitive behavioural PMPs when offered as routine care by an online therapy clinic.SignificanceThis 5‐year observational study provides support for Internet‐delivered cognitive behavioural pain management programs (PMPs) offered as routine care in an online therapy clinic. Interest in the service grew over 5 years. Outcomes, engagement and satisfaction were strong. Higher pain acceptance, pain self‐efficacy and lower pain severity were associated with greater post‐treatment improvements on depression, anxiety and disability.
Patients’ self‐reported physical and psychological effects of opioid use in chronic noncancer pain—A retrospective cross‐sectional analysis
Authors: Schulte Erika , Spies Claudia , Denke Claudia , Meerpohl Joerg J. , Donner‐Banzhoff Norbert , Petzke Frank , Hertwig Ralph , Schäfer Michael , Wegwarth Odette 
Published: September 2021

AbstractBackgroundStrong opioids can have unintended effects. Clinical studies of strong opioids mainly report physical side effects, psychiatric or opioid use disorders. To date, too little attention has been paid to the psychological effects of opioids to treat patients with chronic noncancer pain (CNCP). This study aims to identify and measure (i) the nature and frequency of physical and psychological effects and (ii) the degree of physician counseling of patients with CNCP taking strong opioids.MethodsWithin a cross‐sectional survey—conducted as part of a randomised controlled online intervention trial (ERONA [Experiencing the risk of overusing opioids among patients with chronic non‐cancer pain in ambulatory care])—300 German CNCP patients were surveyed via patient‐reported outcome measures regarding on both the side effects from their use of strong opioids as well as their counselling experience.ResultsAmong the patients’ reported effects, the psychological outcomes of the opioids in CNCP were: feeling relaxed (84%), fatigue (76%), dizziness (57%), listlessness (37%), difficulty with mental activities (23%), dulled emotions (17%) and poor memory (17%). Ninety‐two per cent of the patients reported having received information about opioid effects, and 46% had discussed cessation of the opioid medication with their physicians before commencing the prescription.ConclusionsIn addition to the well‐known physical side effects, patients with CNCP taking strong opioids experience significant psychological effects. In view of these effects, discontinuation of opioid therapy should be discussed early to ensure their benefits do not outweigh their harm.SignificanceIn this study, patients with non‐cancer pain notice that opioids they have taken do not only cause physical side effects but also may have an impact on their psyche and their emotions and, thus, may also affect quality of life substantially.Clinical trial number: DRKS00020358.
Microdroplet mass spectrometry: Accelerating reaction and application
Authors: Kafeenah Husam , Jen Hung‐Hsiang , Chen Shu‐Hui 
Published: September 2021

AbstractElectrospray ionization (ESI) and desorption electrospray ionization (DESI) are common soft ionization method of mass spectrometry (MS). However, recent studies revealed that some chemical reactions can be induced or greatly accelerated in the sprayed microdroplets compared to the same reaction in the bulk. These open a new area in using microdroplet MS to explore new chemistry and develop new applications. This minireview will introduce microdroplet chemistries and explore various microdroplet techniques most of which are ESI‐ or DESI‐based extensions by incorporating transfer tube, supersonic nebulizing gas, droplet fusion, spray extraction, laser irradiation, or laser ablation for online/offline MS analysis. Potential applications associated with new techniques, including real‐time reaction monitoring, high‐throughput reaction screening, protein identification, and protein characterization, are also described. Future outlook, such as coupling microdroplet MS with separation techniques, is proposed and discussed.
Inverse analysis of dynamic failure characteristics of roadway surrounding rock under rock burst
Authors: Yang Yushun , Wei Sijiang , Li Kui 
Published: September 2021

AbstractRock burst is one of the most serious dynamic disasters in the process of coal resources mining, in order to study its occurrence mechanism and the characteristics of its impact on roadways. Based on the No. 25110 working face of Yuejin Mine in Yi Coal Mine and No. 21032 return air uphill event in Qianqiu Mine, combined with geological conditions, shock location, and source waveform, this paper uses numerical simulation to inverse the dynamic response characteristics of roadway surrounding rock under rock burst. The results show that the plastic strain energy density of No. 25110 working face in Yuejin Mine is mainly distributed around the roadway, and the maximum plastic strain energy density is 3.30 × 107 J at 75 ms, all rock masses around the roadway are damaged, and the maximum damage variable value is 0.44. The plastic strain energy density of No. 21032 return air uphill in Qianqiu mine is mainly distributed around the lower side of the roadway, and the maximum plastic strain energy density is 2.68 × 108 J at 80 ms, all rock masses around the roadway are damaged, and the maximum damage variable value is 1.76, indicating that the rock masses at the roof and two sides of the roadway have been damaged after the impact. Based on the results of numerical simulation, the energy gradient criterion of rock burst tendency was proposed, the degree of energy accumulation of surrounding rock is measured by the change amplitude of energy gradient, and the tendency index of rock burst is quantified, which provides a new method for the prediction of rock burst.
Dynamically switchable magnetic resonance imaging contrast agents
Authors: Wang Qiyue , Liang Zeyu , Li Fangyuan , Lee Jiyoung , Low Liang Ee , Ling Daishun 
Published: September 2021

AbstractContrast agents can improve the sensitivity and resolution of magnetic resonance imaging (MRI) by accelerating the relaxation times of surrounding water protons. The MRI performances of contrast agents are closely related to their structural characteristics, including size, shape, surface modification, and so on. Recently, dynamically switchable MRI contrast agents that can undergo structural changes and imaging functional activations upon reaching the disease microenvironment have been developed for high performance MRI. This perspective highlights the ingenious design, controllable structural transformation, and tunable imaging property of dynamic MRI contrast agents. Additionally, the current challenges of the dynamic MRI contrast agents for medical diagnosis are discussed. Furthermore, the future integration of high‐resolution ultra‐high field MRI technology and cutting‐edge dynamic MRI contrast agents for non‐invasive histopathological level accurate detection of microscopic lesions are commented.
Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
Authors: Cao Kaihui , Zhang Kaiping , Ma Muran , Ma Junjie , Tian Jianjun , Jin Ye 
Published: September 2021

AbstractHypercholesterolemia is the main cause of cardiovascular disease worldwide, and the regulation of cholesterol homeostasis is essential for human health. Lactobacillus is present in large quantities in the human intestine. As the normal flora in the gut, lactobacillus plays an important role in regulating metabolism in the human body. Lactobacillus can regulate the cholesterol content by regulating the expression of genes involved in cholesterol synthesis, metabolism, and absorption. This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABCG8, and other genes to inhibit cholesterol absorption, and discusses the mechanism of reducing cholesterol by lactobacillus in cells in vitro, to provide a theoretical basis for the development and utilization of lactobacillus resources.
Recovery of early meteorological records from Extremadura region (SW Iberia): The ‘CliPastExtrem’ (v1.0) database
Authors: Vaquero José M. , Bravo‐Paredes Nieves , Obregón María Angeles , Carrasco Víctor M. S. , Valente Maria Antonia , Trigo Ricardo M. , Domínguez‐Castro Fernando , Montero‐Martín Javier , Vaquero‐Martínez Javier , Antón Manuel , García José Agustín , Gallego María Cruz 
Published: September 2021

AbstractIn this work, we provide instrumental meteorological data recovered for the Extremadura region (interior SW Iberia), from 1826 to mid‐20th century. Meteorological variables such as air temperature, atmospheric pressure, precipitation, wind direction and humidity, among others, were retrieved. In total, more than 750 000 instrumental data in 157 meteorological series belonging to 131 different locations throughout Extremadura were rescued. It must be noted that daily resolution data constitutes 80% of the database. This great effort of digitization and data collection has been carried out with the aim of contributing to a significant expansion of the length of the databases with meteorological information in this region. Therefore, this database will provide a better understanding of climate variability, trends and extreme events of the Extremadura region.
OTUB1 alleviates NASH through inhibition of the TRAF6‐ASK1 signaling pathways
Authors: Zhang Jie‐Lei , Du Bin‐Bin , Zhang Dian‐Hong , Li Huan , Kong Ling‐Yao , Fan Guang‐Jian , Li Ya‐Peng , Li Peng‐Cheng , Liang Cui , Wang Zheng , Yang Lu‐Lu , Hao Zheng‐Yang , Wu Lei‐Ming , Huang Zhen , Dong Jian‐Zeng , Zhang Jin‐Ying , Yao Rui , Wang Shou‐Jun , Zhang Yan‐Zhou 
Published: September 2021

Abstract

Background and Aims
NAFLD is considered as the hepatic manifestation of the metabolic syndrome, which includes insulin resistance, obesity and hyperlipidemia. NASH is a progressive stage of NAFLD with severe hepatic steatosis, hepatocyte death, inflammation, and fibrosis. Currently, no pharmacological interventions specifically tailored for NASH are approved. Ovarian tumor domain, ubiquitin aldehyde binding 1 (OTUB1), the founding member of deubiquitinases, regulates many metabolism‐associated signaling pathways. However, the role of OTUB1 in NASH is unclarified.

Methods and Results
We demonstrated that mice with Otub1 deficiency exhibited aggravated high‐fat diet–induced and high‐fat high‐cholesterol (HFHC) diet–induced hyperinsulinemia and liver steatosis. Notably, hepatocyte‐specific overexpression of Otub1 markedly alleviated HFHC diet–induced hepatic steatosis, inflammatory responses, and liver fibrosis. Mechanistically, we identified apoptosis signal–regulating kinase 1 (ASK1) as a key candidate target of OTUB1 through RNA‐sequencing analysis and immunoblot analysis. Through immunoprecipitation–mass spectrometry analysis, we further found that OTUB1 directly bound to tumor necrosis factor receptor–associated factor 6 (TRAF6) and suppressed its lysine 63–linked polyubiquitination, thus inhibiting the activation of ASK1 and its downstream pathway.

Conclusions
OTUB1 is a key suppressor of NASH that inhibits polyubiquitinations of TRAF6 and attenuated TRAF6‐mediated ASK1 activation. Targeting the OTUB1‐TRAF6‐ASK1 axis may be a promising therapeutic strategy for NASH.
Nuclear transport proteins are secreted by cancer cells and identified as potential novel cancer biomarkers
Authors: van der Watt Pauline J. , Okpara Michael O. , Wishart Andrew , Parker M. Iqbal , Soares Nelson C. , Blackburn Jonathan M. , Leaner Virna D. 
Published: September 2021

AbstractPrevious studies have identified increased expression of members of the nuclear transport protein family in cancer cells. Recently, certain nuclear transport proteins have been reported to be secreted by cells and found in the serum. The aims of our study were to investigate the levels of multiple nuclear transport proteins secreted from cancer cells, and to determine their potential as diagnostic markers for cervical and oesophageal cancer. Mass spectrometry identified 10 nuclear transport proteins in the secretome and exosomes of cultured cancer cells, and Western blot analysis confirmed increased secreted levels in cancer cells compared to normal. To investigate their presence in patient serum, enzyme‐linked immunosorbent assays were performed and revealed significantly increased levels of KPNβ1, CRM1, CAS, IPO5 and TNPO1 in cervical and oesophageal cancer patient serum compared to non‐cancer controls. Significantly elevated KPNα2 and RAN levels were also identified in oesophageal cancer serum samples. Logistics regression analyses revealed IPO5 and TNPO1 to be the best performing individual candidate biomarkers in discriminating between cancer cases and controls. The combination of KPNβ1, CRM1, KPNα2, CAS, RAN, IPO5 and TNPO1 as a panel of biomarkers had the highest diagnostic capacity with an area under the curve of 0.944 and 0.963, for cervical cancer and oesophageal cancer, and sensitivity of 92.5% at 86.8% specificity and 95.3% sensitivity at 87.5% specificity, respectively. These results suggest that nuclear transport proteins have potential as diagnostic biomarkers for cervical and oesophageal cancers, with a combination of protein family members being the best predictor.
Suspension and expulsion in Colorado early care and education settings: Child, program, and community‐level predictors
Authors: Miles Elly , Stoker Jessica , Senehi Neda , Ash Jordana , Schlueter Lisa , Baumann Carsten , Barney Jacob 
Published: September 2021

AbstractExpulsion presents a significant risk in Early Care and Education (ECE) settings due to its association with early disadvantage and frequency of use. A statewide survey was conducted to characterize ECE suspension and expulsion (S/E) in Colorado. Child, program, and community‐level factors were examined as predictors of S/E, alongside preventative intervention supports capable of reducing S/E. Six hundred and sixty three licensed child care programs participated in the survey, providing information on 19,848 enrolled children, 312 suspensions, and 74 expulsions. A series of multilevel hierarchical regressions were conducted, examining predictors for S/E. Children with IEPs/IFSPs were disproportionately suspended; 2–3‐year‐olds were disproportionately expelled; and boys, 5–6‐year‐olds, and children with disabilities were disproportionately suspended and expelled. Center‐based programs, lower quality ratings, and “zero tolerance” policies predicted greater use of suspension. In contrast, school‐district affiliation and knowledge of how to access infant and early childhood mental health consultation (IECMHC) decreased suspension. Lower levels of regional child poverty predicted higher use of expulsion. Affiliation with a school‐district, IECMH consultant‐led training, and use of quality coaches predicted decreased expulsion. This study identifies the need for ongoing protection for children with IEPs/ IFSPs and the preventative interventions that mitigate risk for S/E.
Trends in Dentistry and Dental Education
Authors: Valachovic Richard W. , Weaver Richard G. , Sinkford Jeanne C. , Haden N. Karl 
Published: September 2021

This report represents the second edition of Trends in Dental Education, which was first published in 2000. Trends is compiled from many of the surveys that the American Dental Education Association routinely publishes. They include the ADEA Survey of Dental Educators, the ADEA Faculty Salary Survey, the ADEA Applicant Analysis, the ADEA Senior Survey, the ADEA Survey on Student Financial Assistance, and ADEA Survey of Clinic Fees and Revenues. Appropriate data from other sources are also included, particularly recognizing the American Dental Association surveys of predoctoral, postdoctoral, and allied dental education, as well as health and oral health surveys conducted by various agencies of the U.S. Department of Health and Human Services.We believe that in order for dental and allied dental educators to see the complete picture of the profession, help those outside the field understand it, and plan for the future, this information cannot be examined in isolation, but viewed within the context of patient needs and demands. The statistics and text provide a comprehensive overview of trends over time from which readers can select the most useful information for their particular purposes.
Gelatin methacrylate hydrogel loaded with brain‐derived neurotrophic factor enhances small molecule‐induced neurogenic differentiation of stem cells from apical papilla
Authors: Zou Ting , Jiang Shan , Yi Baicheng , Chen Qixin , Heng Boon Chin , Zhang Chengfei 
Published: September 2021

AbstractThe limited neurogenic potential of adult stem cells and their non‐specific lineage differentiation pose major challenges in cell‐replacement therapy for neurological disorders. In our previous study, we demonstrated that the neurogenic potential of stem cells from apical papilla (SCAPs) was significantly improved upon induction with a small molecule cocktail. This study attempted to investigate whether neuronal differentiation of SCAPs induced by a small molecule cocktail can be further enhanced in a three‐dimensional gelatin methacrylate hydrogel loaded with brain‐derived neurotrophic factor (BDNF‐GelMA). The physiological properties and neural differentiation of SCAPs treated with a combination of small molecules and BDNF‐GelMA were evaluated by CCK8, Live/Dead assay, quantitative reverse transcription‐polymerase chain reaction, western blot and immunocytochemistry. SCAPs embedded in BDNF‐GelMA displayed superior morphological characteristics when induced by a small molecule cocktail, similar to neuronal phenotypes as compared to pure GelMA. There was significant upregulation of neural markers including Tuj1 and MAP2 by SCAPs embedded in BDNF‐GelMA, as compared to pure GelMA. Hence, GelMA hydrogel loaded with a potent neurotrophic factor (BDNF) provides a conducive scaffold that can further enhance the differentiation of small molecule‐treated SCAPs into neuronal‐like cells, which may provide a therapeutic platform for the management of neurological disorders.
Genetic counseling experiences at the University of Cape Town during COVID‐19
Authors: Wessels Tina‐Marié , Düsterwald Gillian , Barlow Robyn , Cameron‐Mackintosh Sinead , Diedericks Angelique , Francois Sydney , Laing Nakita , Pretorius Willem , Scholtz Kathrine , Vorster Nina 
Published: September 2021

AbstractSoon after the first COVID‐19 case was reported in December 2019 in Wuhan, China, South Africa announced a national lockdown in an attempt to curb the spread of the disease. Under national lockdown, businesses were closed, learning institutions moved to emergency remote teaching (ERT), and hospitals reduced their patient loads. De‐escalation of clinical services at Groote Schuur and Red Cross War Memorial Children's Hospitals affected Genetic Counseling Services and resulted in a decrease in in‐person and an increase in telecounseling sessions. ERT, offered by the University of Cape Town, affected the teaching of Genetic Counseling students, and other methods of training had to be found to compensate for the lack of patient contact. In this paper, we present our Genetic Counseling team's experiences of learning and clinical services during the COVID‐19 pandemic in South Africa. The team met online as a group in November 2020 to discuss their experiences. The discussion was recorded and transcribed, and topics that arose during the discussion were identified. The pandemic and the accompanying lock down, which forced trainees to move back home, resulted in great uncertainty. The trainees found ERT on an online platform, including simulated cases, very helpful, but they lost the confidence to work with real patients. Telecounseling became the predominant form of service delivery and was experienced as positive when video sessions were possible. The telephone service for advanced maternal age counseling was problematic due to unreliable networks. The biggest loss for the GCs was the feeling of disconnection from peers, supervisors, and patients. The experiences highlighted positive and negative aspects as well as specific challenges faced in South Africa. Lessons learnt from the COVID‐19 pandemic will be used in future to improve training of GCs and to enhance service delivery.