bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Uveitis in Dengue Fever Patients: A Population‐Based Cohort Study in Taiwan
Authors: Wu Bing‐Qi , Kuo Hou‐Ting , Hsu Alan Y. , Lin Chun‐Ju , Tien Peng‐Tai , Hsia Ning‐Yi , Cheng Yih‐Dih , Hsieh Yow‐Wen , Huang Yu‐Han , Wang Sing‐Ting , Lai Chun‐Ting , Shao Yi‐Ching , Chiang Chun‐Chi , Tseng Hsin , Chen Huan‐Sheng , Tsai Yi‐Yu 
Published: December 2024

ABSTRACTDengue‐related ocular complications were considered rare, but recent evidence points to a broader spectrum of manifestations, including uveitis. This study utilized the Taiwan National Health Insurance Research Database (NHIRD) to investigate the incidence of uveitis in dengue patients, aiming to fill this research gap. This population‐based, retrospective cohort study utilized the Taiwan National Health Insurance Research Database (NHIRD) and included patients with and without Dengue fever. The non‐Dengue fever cohort comprised randomly selected control patients who were matched. Hazard ratios and Kaplan–Meier analysis were conducted to compare the incidence of uveitis in the Dengue and non‐Dengue cohorts. Subgroup analyses were carried out based on age groups, genders, and comorbidities. A total of 26 950 patients diagnosed with Dengue fever were included in the study (49.6% female, mean age at index 41.63 years). Based on a 1:4 matching ratio, 107 800 control subjects without uveitis (50.03% female, mean age at index 41.41 years) were also included. The adjusted hazard ratio (aHR) of uveitis was higher in the Dengue fever group than in the non‐Dengue fever group (aHR = 1.38, p < 0.001). A history of stroke or transient ischemic attack (TIA) was not associated with uveitis. Stratified analyses revealed that patients with Dengue fever had an increased risk regardless of their sex and age. The Kaplan–Meier method with the log‐rank test showed a significantly higher cumulative incidence of uveitis in the Dengue fever cohort than in the non‐Dengue fever cohort (p < 0.001). In the subgroup analysis for most major comorbidities, the significantly higher risk for uveitis in those patients with Dengue fever, was only demonstrated in the subgroups of those without these major comorbidities. Our findings showed Dengue infection to be associated with increased risk for uveitis. Clinicians should be attentive to a history of stroke or TIA in patients with Dengue fever.
Fish oil lipid emulsion compared with soybean oil lipid emulsion in pediatric patients with parenteral nutrition‐associated cholestasis: A cost‐effectiveness study
Authors: Povero Massimiliano , Gura Kathleen M. , Premkumar Muralidhar H. , Pradelli Lorenzo , Puder Mark , Calkins Kara L. 
Published: December 2024

AbstractObjectivesEvidence indicates that, in pediatric patients with parenteral nutrition–associated cholestasis (PNAC), the use of a 100% fish oil lipid emulsion (FOLE) increased the likelihood of PNAC resolution and reduced the likelihood of liver transplantation compared with a 100% soybean oil lipid emulsion (SOLE). To evaluate the potential economic benefit, we conducted a cost‐effectiveness analysis comparing FOLE with SOLE.Study DesignA discrete event simulation model evaluated cost‐effectiveness by simulating clinical outcomes and estimating associated healthcare costs in pediatric patients with PNAC receiving parenteral nutrition (PN) with FOLE (1 g/kg) or SOLE (1.9 g/kg) over a time horizon of 6 years. Model inputs for clinical outcomes were derived from the integrated analysis of two US Phase 3 trials (NCT00910104 and NCT00738101). Cost estimates were estimated from the perspective of the US payer including the cost of PN, transplantation, and adverse events.ResultsThe total cost associated with FOLE was $69,847 USD vs $141,605 USD for SOLE. The cost reduction of $71,757 USD was attributable to the avoidance of liver transplantation (−15.7%) and reduction in adverse events (−4.8%). Life‐years and the quality‐adjusted life‐years were increased with FOLE compared with SOLE (by 0.248 and 0.295, respectively).ConclusionBy reducing the need for liver transplant and providing time to transition to full enteral nutrition, FOLE leads to cost‐savings, compared with SOLE, in pediatric patients with PNAC in the perspective of the US payer. These findings support the use of FOLE in pediatric patients with PNAC who require PN.
Effects of black soybean peel anthocyanins on the structural and functional properties of wheat gluten
Authors: Wu Tongyun , Sun Jianxia , Bai Weibin 
Published: December 2024

AbstractBACKGROUNDWheat gluten (WG) is a crucial cereal protein commonly utilized in the food, biological and pharmaceutical industries. However, WG is poorly soluble in water, resulting in poor functional properties, which restrict its application in the food industry. As a result, there is an urgent need for improving the properties of WG.RESULTSThis study was conducted to examine the functional properties of WG after binding with black soybean peel anthocyanin extract (BAE). Results showed that BAE enhanced the solubility, water‐holding and antioxidant capacity, foaming properties and emulsifying activity of WG, while decreasing the emulsion stability. The degree of hydrolysis of WG and retention rate of BAE became higher in the digested WG–BAE complex than in the control groups. Additionally, an analysis was conducted on the mechanism of interaction between cyanidin‐3‐O‐glucoside (C3G) and WG/gliadin (Gli)/glutenin (Glu). The secondary structure of WG/Gli/Glu was altered after adding C3G. C3G had high affinity for WG/Gli/Glu since their binding constants were greater than 104 L mol−1. The primary binding forces between C3G and WG/Gli were hydrophobic interactions, whereas the main interaction forces between C3G and Glu were hydrogen bonding and van der Waals forces. Moreover, C3G increased the thermal stability and changed the network structure of WG/Gli/Glu.CONCLUSIONThis study revealed that BAE effectively enhanced a range of functional properties of WG. The interaction between WG and BAE also improved the bioavailability and nutritional value of them. Furthermore, the interaction mode between BAE and WG was investigated. These findings lay a foundation for utilizing gluten–anthocyanins in the food sector. © 2024 Society of Chemical Industry.
From physicochemical characteristics variability to purple passion fruit (Passiflora edulis f. edulis) powders nutritional value: on the path of zero‐waste
Authors: Fonseca Alexandre M. A. , Silvestre Armando J. D. , Rocha Sílvia M. 
Published: December 2024

AbstractBACKGROUNDPurple passion fruit (Passiflora edulis f. edulis) is a highly appreciated fruit typically consumed in fresh or processed into various food products. The peel and seeds, which are by‐products of fruit processing, are rich in nutrients and bioactive compounds with potential to be valorised into food applications. However, raw material variability is often a major obstacle to successfully achieve such valorisation. The present study aimed to contribute to a zero‐waste valorisation strategy of purple passion fruit by evaluating its temporal variability and provide a comprehensive insight into the nutritional value of fruit fraction powders.RESULTSFruit analysis demonstrated similar characteristics between three consecutive harvests because variation observed on maturity parameters, fruit mass and dimensions, fractions fresh weight, moisture, total phenolic compounds and antioxidant activity was not significant. This was attained despite variable weather conditions, as long as irrigation was provided during fruit development to avoid water stress. The development and subsequent analysis of the nutritional value of minimum processed powders of the fruit (peel, pulp and seeds) revealed that they can be used as a source of several macronutrients, essential minerals and vitamins. A single serving (10 g) of these fruit powders provide enough fiber (peel and seeds) and vitamin C (peel and pulp) to sustain nutritional claims.CONCLUSIONThe present study provides valuable insights into the maintenance of physicochemical properties of all fruit fractions across three consecutive harvests. The nutritional characterization of fruit fractions also contributes to move towards a zero‐waste value chain in passion fruit processing through whole fruit usage. © 2024 Society of Chemical Industry.
Multimodality Treatment Outcome in Adult Patients with Head and Neck Rhabdomyosarcoma
Authors: Wang Tian , Huang Chuang , Wang Jie , Tang Tianci , Li Qiang , Li Yi , Song Xinmao 
Published: December 2024

Objective(s)Head and neck rhabdomyosarcoma (HNRMS) is a rare malignant tumor in adults. No standard treatment for adults with HNRMS currently exists.MethodsA retrospective study of 72 newly diagnosed consecutive adult patients with HNRMS was conducted at one institution between November 2010 and April 2023. The log‐rank tests were used to compare the differences in survival between treatment groups, and overall survival (OS), local recurrence‐free survival (LRFS), progression‐free survival (PFS), and distant metastasis‐free survival (DMFS) were calculated using the Kaplan–Meier method. We used restricted cubic spline models fitted for Cox proportional hazards models to determine the association between chemotherapy cycles/radiotherapy dose and mortality.ResultsThe 2‐year OS, PFS, LRFS, and DMFS rates for the entire cohort were 51.0%, 39.2%, 44.3%, and 47.3%, respectively. Radiotherapy significantly improved the OS (p < 0.01), PFS (p < 0.01), LRFS (p < 0.01), and DMFS (p < 0.01). Surgery had no effect on OS (49.3% vs. 53.0%, p = 0.62), PFS (36.9% vs. 41.8%, p = 0.31), LRFS (41.6% vs. 47.4%, p = 0.27), or DMFS (44.4% vs. 50.2%, p = 0.43). The restricted cubic spline showed that eight (HR = 1.002, 95% CI: 0.996–1.007) cycles of chemotherapy and 62.5Gy radiation therapy resulted in the lowest mortality.ConclusionFor HNRMS, eight cycles of chemotherapy and 62.5Gy of radiation might be sufficient. Poor response to chemotherapy predicted an extreme worse outcome. Surgery played a limited role in the treatment.Level of EvidenceIII Laryngoscope, 2024
Identifying and quantifying unexpected deep zooplankton diel vertical migration in a large deep lake
Authors: Piton Violaine , Reiss Rafael , Lemmin Ulrich , Anneville Orlane , Many Gaël , Keller Jérémy , Kindschi Valentin , Wynn Htet Kyi , Rasconi Serena , Laine Leslie , Barry David Andrew 
Published: December 2024

AbstractDiel Vertical Migration (DVM), a widespread zooplankton behavior in freshwater and marine systems, affects ecological interactions and biogeochemical cycles. In lakes, DVM has mainly been studied in the upper 50 m of the water column. However, based on acoustic and net sampling data collected in Lake Geneva, Switzerland (~ 309 m depth) during summer 2022, we demonstrate that DVM occurs down to ~ 125 m depth daily throughout the summer season. The daily descents terminated at around zenith when the Relative Rate of light Change (RRC) was the lowest, and the late afternoon ascent started when RRC values exceeded −0.005 s−1. DVM migration descent/ascent rates were asymmetric with faster mean upward rates () than downward rates (). Migration rates overall increased as summer progressed, corresponding to the intra‐seasonal increase in RRC. Cyclopoid copepods Cyclops prealpinus abundances correlated with the observed deep DVM and their migration responded to exogenous light cues. These new findings, which can also be expected to be relevant for other deep lakes, indicate that Lake Geneva's DVM greatly exceeds maximum migration depths previously reported for a lake. Thus, it is important to study zooplankton DVM dynamics throughout the entire water column in large, deep lakes since it plays an important role in buffering global climate change effects. Furthermore, it is suggested that present zooplankton DVM sampling protocols in large, deep lakes should be revised accordingly.
Temperature, pH, and diet interactively affect biosynthesis of polyunsaturated fatty acids in a benthic harpacticoid copepod
Authors: Boyen Jens , Rodríguez María T. , Vlaeminck Bruno , Fink Patrick , Hablützel Pascal I. , De Troch Marleen 
Published: December 2024

AbstractGreenhouse gas emissions lead to ocean warming and acidification, negatively impacting marine organisms and their functioning, including long‐chain polyunsaturated fatty acid (LC‐PUFA) production by marine microalgae. Copepods, primary consumers of microalgae, possess a unique capacity for endogenous LC‐PUFA biosynthesis, possibly enabling them to cope with reduced dietary LC‐PUFA availabilities. However, this capacity may be itself impacted by changing oceanographic conditions. In this study, we conducted a laboratory experiment to evaluate the combined effects of warming (+3°C), acidification (−0.4 pH), and dietary LC‐PUFA deficiency on the fatty acid composition and LC‐PUFA biosynthesis (measured by quantitative RT‐PCR) of the benthic harpacticoid copepod Platychelipus littoralis (Brady, 1880). We hypothesized increased LC‐PUFA biosynthesis under all drivers compensating for LC‐PUFA reductions. Lipid profiles of copepods exposed to multiple stressors contained shorter‐chained and more saturated fatty acids. While copepods maintained base‐line relative concentrations of the physiologically important LC‐PUFA docosahexaenoic acid (DHA) on an LC‐PUFA deficient diet at ambient temperatures, DHA concentrations decreased significantly with higher temperatures. Expression of the DHA biosynthesis genes Δ4 front‐end desaturase and elovl1a increased under dietary LC‐PUFA deficiency but did not exceed base‐line levels when simultaneously exposed to acidification. Expression of Δ4 front‐end desaturase and multiple elongases correlated positively with C18 precursor concentrations and negatively with those of LC‐PUFAs such as DHA, indicating their role as LC‐PUFA biosynthesis enzymes. Overall, our findings suggest that ocean warming and acidification may impede benthic copepods' LC‐PUFA biosynthesis capacity under reduced dietary inputs, limiting their contribution toward global LC‐PUFA availability for higher trophic levels.
Metastatic brain tumors: from development to cutting‐edge treatment
Authors: Tanzhu Guilong , Chen Liu , Ning Jiaoyang , Xue Wenxiang , Wang Ce , Xiao Gang , Yang Jie , Zhou Rongrong 
Published: December 2024

AbstractMetastatic brain tumors, also called brain metastasis (BM), represent a challenging complication of advanced tumors. Tumors that commonly metastasize to the brain include lung cancer and breast cancer. In recent years, the prognosis for BM patients has improved, and significant advancements have been made in both clinical and preclinical research. This review focuses on BM originating from lung cancer and breast cancer. We briefly overview the history and epidemiology of BM, as well as the current diagnostic and treatment paradigms. Additionally, we summarize multiomics evidence on the mechanisms of tumor occurrence and development in the era of artificial intelligence and discuss the role of the tumor microenvironment. Preclinically, we introduce the establishment of BM models, detailed molecular mechanisms, and cutting‐edge treatment methods. BM is primarily treated with a comprehensive approach, including local treatments such as surgery and radiotherapy. For lung cancer, targeted therapy and immunotherapy have shown efficacy, while in breast cancer, monoclonal antibodies, tyrosine kinase inhibitors, and antibody–drug conjugates are effective in BM. Multiomics approaches assist in clinical diagnosis and treatment, revealing the complex mechanisms of BM. Moreover, preclinical agents often need to cross the blood–brain barrier to achieve high intracranial concentrations, including small‐molecule inhibitors, nanoparticles, and peptide drugs. Addressing BM is imperative.
Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial
Authors: Zhao Jianli , Yu Yunfang , Ren Wei , Ding Linxiaoxiao , Chen Yongjian , Yuan Peng , Yue Jian , Yang Yaping , Zou Guorong , Chen Tao , Chai Jie , Zhang Li , Wu Wenjing , Zeng Yinduo , Gui Xiujuan , Cai Yangyang , Luo Simin , Yuan Zhongyu , Zhang Kang , Yao Herui , Wang Ying 
Published: December 2024

AbstractThis multicenter, single‐arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR‐positive/HER2‐positive metastatic breast cancer who had experienced trastuzumab treatment failure. A total of 46 patients were enrolled, receiving pyrotinib orally once daily and fulvestrant intramuscularly on days 1 and 15 of cycle 1, followed by monthly doses on day 1. The primary endpoint was progression‐free survival (PFS), while secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety. The median PFS was 18.2 months (95% CI, 11.9–31.1) overall, 19.5 months (95% CI, 10.6–NA) for those receiving the combination as first‐line therapy, and 18.4 months (95% CI, 16.7–NA) for patients with brain metastases. Median OS was not reached, with a 3‐year OS rate of 75.2% (95% CI, 62.8–90.2%). The ORR was 32.5%, and the DCR was 97.5%. Responses were observed in patients with low tumor mutation burden and ZNF217 mutation. Importantly, no grade 4 or higher treatment‐related adverse events or deaths were reported, indicating a favorable safety profile. In conclusion, the combination of pyrotinib and fulvestrant demonstrated promising antitumor activity and acceptable safety in HR‐positive/HER2‐positive metastatic breast cancer patients.
Subthalamic γ Oscillation Underlying Rapid Eye Movement Sleep Abnormality in Parkinsonian Patients
Authors: Guan Lingxiao , Yu Huiling , Chen Yue , Gong Chen , Hao Hongwei , Guo Yi , Xu Shujun , Zhang Yuhuan , Yuan Xuemei , Yin Guoping , Zhang Jianguo , Tan Huiling , Li Luming 
Published: December 2024

AbstractBackgroundAbnormal rapid eye movement (REM) sleep, including REM sleep behavior disorder (RBD) and reduced REM sleep, is common in Parkinson's disease (PD), highlighting the importance of further study on REM sleep. However, the biomarkers of REM disturbances remain unknown, leading to the lack of REM‐specific neuromodulation interventions.ObjectiveThis study aims to investigate the neurophysiological biomarkers of REM disturbance in parkinsonian patients.MethodsTen PD patients implanted with bilateral subthalamic nucleus‐deep brain stimulation (STN‐DBS) were included in this study, of whom 4 were diagnosed with RBD. Sleep monitoring was conducted 1 month after surgery. Subthalamic local field potentials (LFP) were recorded through sensing‐enabled DBS. The neurophysiological features of subthalamic LFP during phasic and tonic microstates of REM sleep and their correlation with REM sleep fragmentation and RBD were analyzed.ResultsDifferences in subthalamic γ oscillation between phasic and tonic REM correlated positively with the severity of REM sleep fragmentation. Patients with RBD also exhibited stronger γ oscillations during REM sleep compared with non‐RBD patients, and both increased β and γ were found before the onset of RBD episodes. Stimulation changes in simulated γ‐triggered feedback modulation followed more closely with phasic REM density, whereas an opposite trend was found in simulated β‐triggered feedback modulation.ConclusionExcess subthalamic γ oscillations may contribute to REM instability and RBD, suggesting that γ oscillation could serve as a feedback signal for adaptive DBS for REM sleep disorders. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Existence and Uniqueness Results for Fractional Differential Equations With Nonlocal Conditions in Lp$$ {L}^p $$ Spaces
Authors: Kumar Saha Kiran , Sukavanam N. 
Published: December 2024

ABSTRACTThis paper deals with nonlocal initial value problems (IVPs) for modified Caputo fractional differential equations (FDEs) of order . The novelty of this work is that the nonlinearity is considered in spaces, where , instead of the conventional space of continuous functions. In each scenario, we meticulously derive the equivalences between the FDEs and the corresponding integral equations in the spaces of interest. Several new existence and uniqueness results based on the Banach contraction principle are established, imposing weaker assumptions on the data as much as possible. To exemplify our main results, we present three constructive examples, together with their corresponding unique solution trajectories.
Local Well‐Posedness to the Magneto‐Micropolar Boundary Layer Equations in Gevrey Space
Authors: Tan Zhong , Zhang Mingxue 
Published: December 2024

ABSTRACTWe study the boundary layer equations for two‐dimensional magneto‐micropolar boundary layer system and establish the existence and uniqueness of solutions in the Gevrey function space without any structural assumption, with Gevrey index . Inspired by the abstract Cauchy‐Kovalevskaya theorem, our proof is based on a new cancellation mechanism in the system to overcome the difficulties caused by the loss of derivatives. Our results improve the classical local well‐posedness results presented in a previous study, specifically for cases where the initial data are analytic in the ‐variable.
Investigation of Potential Food Intake Biomarkers by LC‐MS/MS: Suitability Under Conditions Close to Everyday Live
Authors: Frank Amelie , Hübner Florian , Humpf Hans‐Ulrich 
Published: December 2024

ABSTRACTScopeFood intake biomarkers are proposed to be a more reliable tool for investigating the nutritional status compared to food diaries or food frequency questionnaires. Nevertheless, biomarkers have some disadvantages such as the influence of the individual lifestyle, different metabolism, nutrient–nutrient interaction or the specificity of the used biomarkers. To evaluate the suitability of several biomarkers, a study under conditions close to everyday life was conducted.Methods and resultsTen healthy volunteers were divided into three groups who followed different meal plans for 24 h and collected their entire urine. Afterward, several potential biomarkers were quantified using an LC‐MS/MS approach. To further investigate the suitability of those biomarkers, the results were investigated with the main goal of grouping the participants according to their provided diet, while the first author did not have any knowledge of the meal plans or other specific knowledge about the study design.ConclusionThe use of different biomarkers enables the evaluation of different eating habits without any prior wash out period or bigger than usual portion sizes. Especially long‐term biomarkers seem to have a good suitability. Very high intakes and very low intakes are easier to distinguish than a moderate intake. Food intake biomarkers are proposed as a more reliable tool than food diaries or food frequency questionnaires. Nevertheless, data under realistic conditions are rarely available. In this study, ten volunteers were divided into three groups with different meal plans. An LC‐MS/MS approach was performed and the data were further investigated with the main goal of grouping the participants according their provided diet, while the first author did not have any knowledge about the meal plans.
Computational NMR Structural Revision of Marinoaziridines A and B
Authors: Navarro‐Vázquez Armando 
Published: December 2024

ABSTRACTThe putative structures of alkaloids marinoaziridine A and B, the last a recent target of total synthesis, are here revised, on the basis of NMR computer‐assisted structural elucidation and DFT prediction of 1H and 13C chemical shifts, as pyrroloquinoline alkaloids structurally very similar to the marinoquinolines isolated from the same source.