bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical activity as hypertension and diabetes mellitus risk factors in the adult population, measured using an adaptation of the Global Physical Activity Questionnaire (GPAQ)
Authors: Setyawan Sigit , Wijayanti Lilik , Supriyana Dwi Surya , Listyaningsih Endang , Riyadi Slamet , Ma’rufah Siti , Haryati Sri , Negara Khesara Sastrin Prasita , Sari Yulia , Dirgahayu Paramasari , Sawartuti Retno 
Published: January 2025

Link of Video Abstract: https://youtu.be/O1q96lFA5q0

Background: The prevalence of metabolic syndrome (MetS) is disproportionately high in elderly adults as a result of complex, continuing socioeconomic influences. Insulin resistance, abdominal obesity, hypertension, hypertriglyceridemia, high blood sugar, and low HDL-C are all symptoms of mets. This descriptive study described the levels of physical activity, sedentary behavior, and MetS risk variables in the older population.
Methods: Community members were asked to complete the Global Physical Activity Questionnaire (GPAQ) and a survey on self-reported MetS risk factors (n = 120). Data were analyzed using SPSS version 22.0 for Windows.
Results: Chi-square tests were used to analyze the data. With a BMI of 31.4 (8.2) kg/m2, the average (SD) age was 57.8 years (14) old. Across age groups, the intensity of sedentary, work-related, and leisure physical activity (PA) was reported. For those aged 50, 50-60, and 60+, the median (interquartile range) daily sedentary time was 200 (78, 435), 240 (120, 420), and 180 (60, 300), respectively (p = 0.973).
Conclusion: To adopt targeted methods to lower the prevalence of chronic disease in this situation, it is crucial to have a thorough understanding of the types, frequencies, and intensities of the older community. Future community-based initiatives should lower MetS risk factors and enhance quality of life.
Neutrophil – Lymphocyte Ratio (NLR) predicts poor outcome in post-cardiac surgery involving aortic cross-clamping among pediatric patients with Congenital Heart Diseases (CHD): a literature review
Authors: Raharjo Fumansha Cipto , Soebroto Heroe , Utamayasa I Ketut Alit 
Published: January 2025

Link of Video Abstract: https://youtu.be/LS9N9Q61Nqg

Background: Neutrophil-Lymphocyte Ratio (NLR) has been reported as an independent risk factor of poor outcomes in post-operative patients. Higher NLR is associated with extended Length of Stay (LOS) and nosocomial infections. Aortic Cross Clamping (ACC) is a procedure involved in many open-heart surgeries. Clamping and unclamping the aorta has been shown to cause several changes within the vascular lining, which include promoting inflammatory processes due to vascular remodeling.
Methods: The literature reviewed in our study was gathered from PubMed and Google Scholar. An advanced search was conducted on both Google Scholar and PubMed Builder, with the keywords used being ("Neutrophil-Lymphocyte Ratio") AND "Outcome," AND "Aortic Cross Clamping" AND "congenital heart disease". We also reviewed the articles cited within the literature to broaden the search results.
Results: From all 5 selected articles, it could be concluded that NLR counts are statistically significant with the prognosis or outcome of post-cardiac surgery in pediatric patients with aortic cross-clamping and/or CPB duration. A more than 2-3 ratio shows a significant difference in subjects with longer hospital and ICU stays and nosocomial infections.
Conclusions: The NLR ratio predicts worse outcomes in patients with CHD post-cardiac surgery involving CPB and ACC. A higher NLR ratio is significantly associated with extended LOS in the hospital and ICU, the use of mechanical ventilation, and nosocomial infection.
Profiles of molecular subtypes and clinical responses to anthracycline-based neoadjuvant chemotherapy in locally advanced breast cancer at Dr. Soetomo General Hospital, Surabaya
Authors: Rahman Hadian , Ali Iskandar , Susilo Dwi Hari 
Published: January 2025

Link of Video Abstract: https://youtu.be/p3fI1xefgYg

Introduction: Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes. The molecular subtype of breast cancer is one of the significant predictors of chemotherapy response. Until now, anthracycline-based neoadjuvant chemotherapy (NACT) is still one of the recommendations in the management of locally advanced breast cancer (LABC).
Methods: Between January 2017 and December 2021, a descriptive study was performed on 130 LABC patients receiving anthracycline-based NACT at Dr. Soetomo General Hospital Surabaya. Information on demographics, stage, chemotherapy regimen, number of cycles, histology, and immunohistochemistry testing was gathered from the patient's medical record. Human epidermal growth factor receptor 2 (HER2) positive was +3, high Ki-67 ≥ 20%, and 1% were the cut-off values for positive hormone receptors (HR) status for both estrogen receptor (ER) and progesterone receptor (PR).
Results: Out of the 130 patients, we found Luminal A subtype in 11 patients (8.5%), luminal B 83 patients (63.8%), HER2-enriched 14 patients (10.8%), and triple-negative breast cancer (TNBC) 22 patients (16.9%). The clinical response of anthracycline-based NACT in the Luminal A subtype was 81.8%, Luminal B was 71.1%, HER2-enriched was 92.9%, and TNBC was 45.5%.
Conclusion: The Luminal B subtype is the most common molecular subtype in LABC patients at Dr. Soetomo General Hospital Surabaya. In contrast, the HER2-enriched subtype had the highest clinical response to anthracycline-based NACT.
The differences in quality of life between open thoracotomy and video-assisted thoracoscopic surgery (VATS): a literature review
Authors: Heluth M Hanafie , Winarno Dhihintia Jiwangga Suta , Sembiring Yan Efrata 
Published: January 2025

Link of Video Abstract: https://youtu.be/4tAH6YzX6l0

Introduction: Thoracotomy is considered one of the most common surgical procedures related to pain. Patients may consider postoperative complications (such as pain) in the hospital as an acceptable risk, but patients are not ready to accept long-term disability that can affect the patient's daily life.
Methods: This article was conducted by analysis and synthesis from various references. The author uses “video-assisted thoracoscopic surgery-VATS" AND “Open Thoracotomy” AND “Quality of Life" as keywords to explore the literature from PubMed, Google Scholar, ProQuest, and Clinical Key. The related papers published in the last fifteen years were included and non-full-text papers were excluded. These papers were analyzed subsequently to answer the aim of this study.
Results: We obtained a total of four articles that met our review criteria. Up to six journals were extracted from PubMed, Google Scholar, ProQuest, and Clinical Key. According to our review method considerations, many articles excluded by the year of publication criteria are out of date.
Conclusions: Most studies still show VATS's superiority over thoracotomy. There is a difference in the quality-of-life scores of patients after VATS compared to thoracotomy. VATS shows an improvement in quality of life after the procedure. VATS revealed significantly better results in physical function, physical role, bodily pain, and general health than open thoracotomy.
Between policy and practice: a qualitative insights into government-led stunting reduction programs in Lhokseumawe, Aceh, Indonesia
Authors: Ikhsan Maulana , Putri Baluqia Iskandar , Fonna Tischa Rahayu , Matondang Adinda Fahira Dyen , Mailyn Yaiza Aynaya 
Published: January 2025

Link of Video Abstract: https://youtu.be/4pqURoFHqe0

Background: The 2021 Indonesian Nutrition Status Study (SSGI) found numerous regions have stunting rates above the national average, for instance, in Aceh province, which has been recorded at 33.2%. Numerous strategies have been undertaken to mitigate the prevalence of stunting in Aceh, such as providing additional food, social funds, and iron supplement tablets for adolescent girls in senior high school. However, certain regions, including Lhokseumawe Municipality, have had an upward trend in stunting rates, specifically a 0.7% increase from 2021 to 2022. This number indicates that the efforts made by the local health stakeholders thus far have been insufficient to reduce stunting completely.
Methods: This study qualitatively examines the government-led stunting reduction initiative in Lhokseumawe. The study's principal data collection approach is in-depth interviews with families at risk, field officers, and other health stakeholders about stunting reduction program implementation.
Result: The stunting screening process is insufficient in addressing risk factors, lacks focused strategies, and exhibits uneven data collecting. The supplementary food program lacks specificity in addressing the needs of stunted children and encounters complications. Additionally, financing priorities, overlaps, and socioeconomic factors impede the collaboration between governmental and non-governmental institutions.
Conclusion: This study indicates that the government's stunting reduction program is implemented differently in the field. This study contradicts the typical stunting management approach of referring all stunting cases to pediatricians. Additionally, the stunting reduction program only addresses dietary interventions, not risk factors. Due to ineffective coordination between intra- and extra-government bodies, stunting families receive misdirected support.
The differences of sP-selectin and platelet lymphocyte ratio between type 2 diabetes mellitus patients with and without coronary heart disease complication
Authors: Rena Ni Made Renny Anggreni , Adnyana I Wayan Losen , Gautama Putu Gizha Satrya , Chrismayana Nyoman Martha 
Published: January 2025

Background: In its course, T2DM patients can experience various chronic complications, such as coronary heart disease (CHD). The mechanisms of CHD in T2DM patients are very complex. Still, most of it is associated with forming atherosclerotic plaques and activating the thrombotic process. Platelet to lymphocyte ratio (PLR) and serum soluble P-selectin (sP-selectin) levels are thought to be potential new biomarkers to describe chronic inflammatory conditions and the activation of the thrombotic process that precedes the occurrence of CHD complications in T2DM patients. This study aimed to determine differences in PLR values and serum sP-selectin levels in T2DM patients who did not experience coronary heart disease complications and T2DM patients who underwent coronary heart disease complications.
Methods: The design of this study was cross-sectional by taking 34 cases of T2DM with CHD and 34 cases of T2DM without CHD. Samples were selected by purposive sampling of T2DM patients treated at the polyclinic or hospitalized at Prof dr IGNG Ngoerah Hospital from July 2022 to October 2022.
Result: The study found that serum sP-selectin levels were significantly higher in T2DM patients with CHD compared with T2DM patients without CHD (21.16 ± 4.96 pg/ml vs. 10.51 ± 1.35 pg/ml, p < 0.001). The PLR value was also significantly higher in patients with T2DM with CHD compared to T2DM without CHD (278.33 ± 93.46 vs. 108.36 ± 2.54, p <0.001).
Conclusion: These studies show that serum sP-selectin levels and PLR values can be used as predictors of chronic inflammation and the activation of the thrombotic process, which underlies the emergence of CHD complications in type 2 DM patients.
Continuity of care and socio-demographic predictors of postpartum family planning utilization among women with a high-risk pregnancy in Indonesia: case-control study
Authors: Kusuma Inggar Ratna , Damayanti Rita , Prasetyo Sabarinah , Andriani Helen 
Published: January 2025

Introduction: Postpartum Family Planning (PPFP) coverage in Indonesia has reached only 23%, which has an impact on the risk of an unwanted pregnancy. Pregnant women with too young, too old, and too many children are one of the factors that cause high maternal and infant mortality rates. This study aims to analyze factors influencing PPFP in mothers with high-risk pregnancies.
Methods: A case-control study of 496 respondents in 66 health centres in Banyumas and Cilacap, Central Java, was selected through random cluster sampling using a researcher-made questionnaire. This research was conducted in 2022.
Results: Factors that influence the use of PPFP are continuity of care (aOR 4.83; 95%CI 1.52-6.81; p=0.001), medical history during pregnancy and childbirth (aOR 3.31; 95%CI 1.39-5.48; p=0.021), parity (aOR 3.49; 95%CI 0.94-13.04; p=0.030), prior contraception (aOR 6.88; 95%CI 3.92-11.91; p=0.001), Information Education and Communication (aOR 17.72; 95%CI 10.73-20.15; p=0.001), husband support (aOR 8.92; 95%CI 5.1-15.92; p=0.001), health service satisfaction (aOR 4.21; 95%CI 1.26-5.78; p=0.001). In contrast, several factors like the mother's age, mother's educational status, and lactational amenorrhea method do not influence the use of PPFP.
Conclusion: A history of high-risk pregnancies, births, and postpartum heavily influences PPFP. It has been demonstrated that PPFP considerations can lower maternal and newborn mortality rates. Programs to increase the coverage of PPFP participation need to consider various factors, both internal to the mother and external to program readiness.
Profile of arterial blood gas analysis of COVID-19 patients based on severity, ICU admissions, and clinical outcomes
Authors: Iriani Anggraini , Prabowo Ichsandiaz , Fatina Marsya Kaila , Armenia Dhinasty , Putri Dian Eka , Gemilang Rizka Kurnia 
Published: January 2025

Introduction: Arterial Blood Gas parameters (ABG) describe the adequacy of oxygenation and ventilation in COVID-19 patients. This study aims to assess the profile of ABG parameters to assess COVID-19 severity, ICU admissions, and clinical outcomes in hospitalized COVID-19 patients.
Methods: A retrospective cohort study was conducted on 152 adult patients who confirmed COVID-19 during the pandemic. Patients were grouped based on disease severity, need for ICU care and patient outcome. Blood gas analysis was carried out namely pH, pCO2, pO2, HCO3, and O2 saturation.
Results: A total of 152 COVID-19 patient data were collected. There were 84 male and 68 female subjects. Most of the subjects were in the age group > 60 years old (47.3%). There 57.9% of subjects were treated within 1-10 days, and 38.8% were treated within>10 days. A total of 117 (77%) subjects had severe or critical symptoms, 50% of subjects required ICU care, and 82 (54%) subjects were not survived. A total of 97 (64.1%) subjects experienced a decrease in SO2. Subjects had an acidotic pH of 19.1% and alkalosis of 30.9%. Lower PO2 values were found in patients with severe/critical symptoms and patients with non-survived clinical outcomes (p<0.001). Lower pH (p<0.002) and HCO3 values were found in the group of non-survived subjects (p<001).
Conclusions: The significant decrease in PO2 and oxygen saturation parameters occurred based on the patient’s severity and clinical outcome. Decreased HCO3 levels are only significant in non-survived subjects, while most of the subjects have normal pH levels.
The analysis of determinant factors influencing the functional outcome of lower extremity fractures treated at Dr. Wahidin Sudirohusodo General Hospital
Authors: Kurniawan Tri , Biakto Karya Triko , Nong Ira , Usman Muhammad Andry , Arifin Jainal 
Published: January 2025

Introduction: Fractures occurring in the lower limb comprise approximately one-third of all fractures and can significantly contribute to both mortality and morbidity. These injuries exert multifaceted impacts on individuals' functional status, influencing various aspects of their mobility and daily activities, and 50% of patients fail to recover their pre-injury level of function fully. This study analyzes the factors contributing to the functional outcome of lower extremity fractures.
Methods: This is an analytic-observational study with a cross-sectional approach, with the samples being all patients who underwent surgery for lower extremity fractures from January 2019 to December 2021. This study evaluates the location of the fracture, AO classification, injury severity, associated injury, and definitive treatment as determinant factors for the functional outcome of lower extremity fractures, as shown by the Lower Extremity Functional Scale (LEFS).
Result: Seventy-five patients meeting the specified inclusion and exclusion criteria were included in the study. A statistically significant relationship was observed between the fracture location and LEFS score (p = 0.03), with diaphysis fractures having the most important effect compared to fractures around joints (p = 0.00). In contrast, no significant relationship was found between the fracture configuration, injury severity, associated injury, definitive treatment, and LEFS score.
Conclusion: The location of the fracture significantly influences the functional outcome, especially on diaphysis fractures compared to around joint fractures, whereas factors such as the configuration of the fracture, injury severity, associated injuries, and definitive treatment did not show significant effects on the functional outcome.
Electrical burn injury in a 12-year-old male: a case report
Authors: Karamoy Ovi Octavia , Edwar Pesta Parulian Maurid 
Published: January 2025

Background: Burns in children remain a devastating concern on critical care as leading to high rates of morbidity and mortality. Among all the causes of burn injury globally, 4-5% of burns are caused by electrical accidents. Electrical injuries can cause damage to deep tissue that extends beyond the obvious skin injury correlated with the electric field strength of its voltage and amperes. This case report aims to present electrical burn injury in a 12-year-old male.
Case Presentation: A 12-year-old male presented to the Emergency Department of Dr. Soetomo General Hospital referred from Mojokerto General Hospital with burns spanning from nine hours before to hospital admission, involving half of his face, neck, chest, stomach, back, both hands, and both legs. Burns brought on by kite ropes getting caught in power pole cables. Patient was assessed preoperatively with severe combustio grade IIA 8%, IIB 57.7%, III 3% (68.5%) et high voltage electrical injury accompanied by ocular thermal injury dextra et sinistra. Patient underwent debridement and wound dressing at the emergency department operating theatre, then continuous fluid resuscitation, ventilation support, enteral nutritional feeding, and prophylaxis antibiotic administration in the intensive care unit. Blood and urine culture results were sterile. Patient condition has been stable upon the treatment.
Conclusion: Electrical voltage contributed to a small percentage of burn injury in children with significant physiological and psychological differences compared to adult counterparts. Management approaches of severe electrical burn injury mainly consists of fluid resuscitation, ventilation, surgical treatment, antibiotic therapy, and nutritional support.
Diagnostic performance of utilizing a single-dye method for sentinel lymph node biopsy in papillary thyroid cancer
Authors: Wibisana I Gusti Ngurah Gunawan , Yulian Erwin Danil , Kurnia Ahmad , Ham Maria Francisca 
Published: January 2025

Link of Video Abstract: https://youtu.be/Xs6hpFJXL_4

Introduction: Even in the early stages of papillary thyroid cancer (PTC), central compartment lymph node metastases are frequently observed. Prophylactic central compartment neck dissection (pCCND) is still debatable in terms of its impact on the prognosis of the patient. By identifying the sentinel node (SN), which initially achieves lymphatic flow from its original tumour, Sentinel Lymph Node Biopsy (SLNB) utilizing a single dye procedure of methylene blue can be employed as an option for therapy. The study's objective was to assess the effectiveness of the SLNB approach in identifying central compartment metastases in PTC patients by utilizing methylene blue.
Methods: A prospective study at Cipto Mangunkusumo Hospital was conducted between 2016 and 2017, enrolling 68 PTC patients (T1-T3, cN0). All patients underwent thyroidectomy and pCCND dissection following a perinodular injection of 1 cc methylene blue. The histological outcomes of the sentinel nodes (SNs) were compared with those of other lymph nodes in the central compartment.
Result: 19% of cases of lymph node metastases to the central compartment. SNs were detected in 56 of 68 patients (82.3%). Of the 56 SLNs that were discovered, 13 had lymph nodes that were positive for metastases; 11 of them also had NSLNs that were positive for metastases. Positive NSLNs were not found in any of the patients with negative SLNs. In conjunction, SNs had a 100% negative predictive value (NPV) for central compartment metastases (95% confidence interval = 91.8–100) with no false negative rate. There was no evidence of recurrent laryngeal nerve damage or persistent hypoparathyroidism.
Conclusion: SLNB using methylene blue was a significant predictor of NSLNs and can be used to select patients who would benefit from pCCND.
Willingness to pay for the sustainability of the Aceh Health Insurance Program among households in Aceh, Indonesia
Authors: Busyra Anwar , Ibrahim Roszita , Aizuddin Azimatun Noor , Hassan Nor Haty , Saputra Irwan 
Published: January 2025

Background: The urgency of researching health financing is evident in the global concern over the escalating costs of health services. In the midst of a sluggish world economy and high levels of inflation, individuals, particularly those in lower-middle-income countries, are increasingly burdened by health-related financial obligations. The Aceh Health Insurance Program, funded by special autonomy funds from the Central Government, plays a crucial role in this context. However, its funding is set to end in 2027, necessitating the people of Aceh to contribute to their health service financing. This study aimed to identify the relationship between socio-demographic and socio-economic characteristics and the willingness to pay (WTP) for health insurance in Aceh, thereby contributing to the sustainability of the Aceh Health Insurance Program.
Methods: The study employed a cross-sectional approach involving respondents from various socio-demographic backgrounds. The study used a comprehensive household survey to collect data. Through a rigorous multistage random sampling approach, a representative sample of 1082 households from four districts in Aceh. Results were found using the Chi-square test on bivariate and logistic regression test on multivariate.
Results: The majority of households (84.8%) are not inclined to pay for health insurance. However, factors such as the number of dependents, occupation, income, and household expenses significantly influence the willingness to pay for health insurance. These findings underscore the importance of considering socio-demographic and socio-economic factors in the design of a new health insurance scheme. This is crucial for ensuring the long-term sustainability of the health insurance program in Aceh, Indonesia.
Conclusion: When planning a new scheme, socio-demographic and socio-economic factors must be considered to ensure the long-term sustainability of the health insurance program in Aceh, Indonesia.