bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Observational Study to Assess Drug Aberrant Behaviours in Chronic Pain Patients on Gabapentinoids
Authors: Berwertz Martyna , Das Sangeeta , Raj John Michael 
Published: April 2021

Aim:
The aim is to explore whether addiction or drug aberrant behavior exists among patients being treated with pregabalin or gabapentin in our outpatient service.

Methods:
A self-administered questionnaire, the current opioid misuse measure (COMM) was distributed to all patients attending the outpatient service. They filled this voluntarily with maintenance of complete anonymity and confidentiality. Statistical analysis was conducted using the SPSS software.

Results:
A total of 52 questionnaires were received. Twenty-one patients were on gabapentin and 19 on pregabalin. Eighty percent of the patients had little or no benefit and yet an attempt to taper the doses was made only in 37.8% patients. About 56.9% patients had COMM scores above 9, the cut off value for detecting drug abuse/misuse. The COMM scores showed a positive association with the dose magnitude of gabapentin (P = 0.006) but not pregabalin. They also showed a significant positive correlation with the duration of treatment with pregabalin (P = 0.000). The Mann–Whitney U-test showed that the COMM scores were significantly higher in the pregabalin group (P = 0.022).

Conclusions:
Our findings suggest gabapentinoids do carry a potential risk of addiction. Pregabalin more than gabapentin may have a potential for drug aberrant behavior. We must regularly review patient's doses and duration of treatment. Large scale studies are needed to validate the findings. Setting up of national pharmacovigilance databases may be the way forward in preventing a potential drug abuse problem.
The effect of variation of tetrahydropentagamavunon-0 concentration in lotion and emulgel formula toward acute dermal irritation study
Authors: Ritmaleni  , Susilo Putri Dina Suci , Wulandari Tia , Zulkarnain Abdul Karim , Murrukmihadi Mimiek 
Published: April 2021

ABSTRACT
Tetrahydropentagamavunon-0 (THPGV-0) is a curcumin metabolite analog which known has a higher antioxidant activity than Vitamin E. This compound has been formulated in lotion as antiaging cosmetics, but the irritation effect is unknown yet. This study aims to analyze the effect of variation of THPGV-0 concentration in lotion and emulgel formula toward acute dermal irritation. The concentrations of THPGV-0 varied to 0.1%, 0.2%, and 0.4% in lotion/emulgel and tested for their physical properties such as organoleptic, homogeneity, pH, spreadability, and adhesion. Acute dermal irritation test is done in accordance with the In vivo Nonclinical Toxicity Test Guidelines by the Indonesian Food and Drug Administration (BPOM). This study showed that Primary Irritation Index (PII) value concentrations of 0.1%, 0.2%, and 0.4% THPGV-0 in lotion formula are 0.014, 0.014, and 0.028 (close to 0) and in emulgel formula are 0.08 at concentration of 0.1%, 0.33 at concentration of 0.2%, and 0.25 at concentration of 0.4%. PII of 0.1%, 0.2%, and 0.4% THPGV-0 in lotion and emulgel is included in negligible irritation response. Hence, the both of THPGV-0 formula in lotion and emulgel are considered safe to use on skin according to this study.
Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat
Authors: Bahtiar Anton , Setyowati Herlina Tri , Mahanani Retno Rela , Wati Azizah , Arsianti Ade , Fadilah Fadilah 
Published: April 2021

ABSTRACT
Postmenopausal women have decreased levels of the hormone estrogen. Reduced estrogen levels will often involve many symptoms that reduced quality of life. This research aims to analyze the effects of Rheum officinale root extract on postmenopausal model rats. To this end, thirty rats underwent ovariectomy (OVX) surgery and six rats were operated without having their ovaries removed. The OVX was confirmed by body weight–uterus weight ratio and a vaginal swab. Six groups of the rats were performed: SHAM group and negative control groups are given vehicle; the positive control was assigned tamoxifen; and the extract has been given three doses 7, 35, and 175 mg/200 g BW, respectively, for 30 days. The calcium content of bone ash was measured using atomic absorption spectrophotometer. Blood pressure was evaluated using CODA®, and the metabolites in the blood were assessed using gas chromatography–mass spectrometry (MS) and high-performance liquid chromatography. As a result, using ultra-performance liquid chromatography (UPLC)-MS, we found that the extract's major component was rhaponticin and its metabolites. The bone calcium levels increased with increasing doses of the extract. In the OVX group, the bone calcium content was decreased significantly 51.56% ± 8.9% g compared with the SHAM group 62.97% ±5.6% g, and the administration of Rheum extract could restore the calcium content of the bone to become 69.27% ± 3.8% g. From the above data, we concluded that Rheum root extracts contain astrigin, rhaponticin, rhapontigenin, and desoxyrhaponticin. Rheum root extract could improve calcium content and lipid profiles of OVX rats by stimulation osteoblastogenesis. Rheum root extracts could control the blood pressure of OVX rats by reducing lipid profiles.
Anti-inflammatory activity and chemical constituents of red limestone
Authors: Duangyod Thidarat , Rujanapan Narawadee , Champakam Sorraya , Charoensup Rawiwan 
Published: April 2021

ABSTRACT
Red limestone is a mixture of turmeric (Curcuma longa L.) powder and limestone which is made from burning shells at high temperature. The yellow mixture turns to red color or deep orange because of the reaction between turmeric and calcium carbonate in limestone. Red limestone is traditionally used to treat many diseases such as abscess, cut wound and insect bite. The purpose of this study was to investigate anti-inflammatory activity and chemical constituents of red limestone. The chemical analysis of red limestone extract by liquid chromatography with tandem mass spectrometry revealed that red limestone consisted of alpha-turmerone and curcumanolide B as major components. These compounds were related with the chemical constituents in C. longa extract which is a main ingredient of red limestone. However, curcuminoids were not detected in red limestone extract. Cytotoxicity of red limestone extract was investigated. Macrophage cell lines (RAW 264.7) and human keratinocyte cell lines (HaCaT cells) were investigated cell viability using MTT assay. Red limestone extract was nontoxic to normal cells such as macrophage cells and human keratinocyte cells. Moreover, the inflammatory activity was detected nitric oxide (NO) secretion in RAW 264.7 cells. The result showed that the extracts inhibited NO in dose-dependent manner and IC50 was found to be 102.42 μg/ml. It suggested that red limestone extract had a potential for anti-inflammatory activity.
Acute toxicity test of kenikir leaf (Cosmos caudatus H.B.K) ethanolic extract on Wistar white male rats with fixed dose procedure method and its effect on histopathology of pancreatic cells
Authors: Herlina Herlina , Amriani Annisa , Sari Indah Permata , Apriani Elsa Fitria 
Published: April 2021

ABSTRACT
In this study, acute toxicity of kenikir leaf (Cosmos caudatus HBK) ethanolic extract was conducted on Wistar white male rats with fixed dose procedure. The extraction method used was maceration using 70% ethanol. A dose of 2000 mg/kgBW was determined as the starting dose based on the preliminary test result. The rats used in the main test were divided into the normal group and the 2000 mg/kgBW dose group, each used five animals in each group. The results of the test showed that there were no deaths or toxic symptoms both of the normal group and the 2000 mg/kgBW dose group. The conducted preliminary test results a dose of 2000 mg/kgBW as the starting dose. Next, main test is done toward two groups of rats: Normal group and 2000 mg/kgBW dose group each consist of five animals. The main test results in neither deaths nor toxic symptoms from those groups. The range of toxic doses of kenikir leaf ethanolic extract that can cause acute toxicity is >2000 mg/kgBW, and hence, this experiment classified in the practically nontoxic category. Statistical analysis on effect to macroscopic organs of the liver, heart, and kidney showed no significance (P > 0.05) from kenikir leaf ethanolic extract. Average levels of biochemical parameters from the 2000 mg/kgBW group and the normal group were in the normal range. Ethanolic extract at a dose of 333 mg/kg BW does not cause severe pancreatic damage, and hence, it is considered safe for use as an antidiabetic.
Functional Outcome of Intra-Articular Fracture of Distal End of Radius Treated by Open Reduction and Internal Fixation with Locking Distal Radius System
Authors: Chandan Kumar , Kumar Ravi , Ranjan Rahul , Amar Rohit 
Published: April 2021

Background:
There is alays been a dilemma in the treatment of intra-articular distal radius fracture (DRF). Close reduction and cast application gives satisfactory result in extra-articular Distal Radial Fractures but there is alays been debate beteen open and close reduction in the intra-articular fracture. Hence, this study is to evaluate effectiveness of open reduction and internal fixation of intra-articular Distal Radial Fractures.

Materials and Methods:
This prospective observational study as carried out in the department of orthopedics, All India Institute of Medical Sciences, Patna, from August 2016 to March 2019. The patient ere included ho qualified the inclusion criteria. The included patient ere treated by open reduction and internal fixation ith distal radius plate. The outcome as assessed in term of anatomical variables (radial dorsal tilt, length, and angle), residual deformity, and subjective result evaluation using Sarmiento's modification of Lind Storm criteria. The complication if any as also noted.

Results:
This study included 30 cases of intra-articular DRF, 12 fractures of AO type B, and 18 fractures of AO type C. Anatomically, 24 patients (80%) had excellent restoration of anatomy, 4 patients (13%) had good restoration and 2 had fair (7%) restoration of anatomy. 93% of patients had excellent to good alignment of fragments and good reduction could not be achieved in 7% of patients resulting in fair or poor results. Functionally, 22 patients (73%) had excellent, 5 good (17%), and 3 patients had fair (10%) restoration of functions.

Conclusion:
Open reduction and internal fixation ith volar plate and scres fixation gives satisfactory (good to excellent) result in intra-articular Distal Radial Fractures.
Assessment Of Labile Metals In Effluents From Lubricating Oil Company In Osogbo Osun State, Nigeria
Authors: Adeniji A.O , Olabanji I.O. , Oluyemi E.A. 
Published: April 2021

Effluent and sediment samples were collected on seasonal basis, comprising of three months (August to October) in the wet season and three months (December to February) in the dry season from five points around a lubricating oil company in Osogbo - Nigeria. The sequential extraction method was used to respectively fractionate the sediment and effluent samples, then analyzed by Atomic Absorption Spectrophotometry (AAS) to determine concentrations of five heavy metals: Mn, Ni Co, Cd and Pb. Results showed that in wet season, higher concentration of Mn was found in exchangeable fraction, Ni and Pb were more pronounced in carbonate bound fraction, Cd in Fe-Mn oxide fraction, while Co was more in residual fraction. In dry season, Pb was more concentrated in exchangeable fraction, Coin residual fraction, Mn in Fe-Mn oxide fraction, Cd in organic matter bound, while Ni was more concentrated in the carbonate fraction. In both seasons for sediment samples, Cd concentrations were found above the set limit by WHO. The speciation study of the effluent showed that, Mn, Co and Ni concentration were found more in Organic substances fraction in both seasons, Pb was more concentrated in free metal ion fraction in wet season while it was high in organic fraction in the dry season. Concentrations of all metals in the effluent samples in both seasons were above the maximum permissible limit for effluent. The high mobility factors of heavy metals in the sediment indicated that the metals were labile and bioavailable thereby making the soil and the living organisms vulnerable to possibility of high heavy metal bioaccumulation.Key Words: Heavy Metals, Speciation, Effluents, Sediment
Strategi Pengembangan Pengelolahan Susu Sari Kedelai di Desa Modopuro Kecamatan Mojosari Kabupaten Mojokerto
Authors: Cahyani Suci Dwi , Imamah Nurul , Wahyuni Susi Tri 
Published: April 2021

Penelitian ini di latar belakangi oleh pengamatan penulis mengenai strategi pengembangan pengelolaan susu sari kedelai di Desa Modopuro dengan segala upaya-upaya yang ada. Penulis mengambil lokasi di Desa Modopuro karena pada lokasi tersebut terdapat industri rumah tangga pembuatan susu sari kedelai sebagai salah satu bentuk usaha keluarga untuk meningkatkan pendapatan keluarga. Penelitian ini bersifat lapangan, Teknik pengumpulan data yang digunakan dalam penelitian ini adalah teknik triangulasi (observasi, wawancara dan dokumentasi). Penelitian ini bertujuan untuk mengetahui bagaimana strategi pengembangan pengelolaan susu sari kedelai dalam menghadapi pesaing dan meningkatkan pendapatkan keluarga di Desa Modopuro. Industri susu sari kedelai ini memiliki peran untuk membantu pendapatan keluarga, mengurangi jumlah pengangguran dan meningkatkan kesejahteraan masyarakat. Pendekatan penelitian yang digunakan penelitian adalah pendekatan kualitatif deskriptif.
ИССЛЕДОВАНИЕ ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ЦИТРУСОВЫХ
ВОЛОКОН В РУБЛЕНЫХ ПОЛУФАБРИКАТАХ
Authors: Берсенева А. , Чернега О.П. 
Published: April 2021

В статье представлены результаты исследований по применению пищевых волокон в
производстве колбасок гриль. Дана органолептическая и технологическая характеристика
цитрусовых волокон Herbacel AQ Plus. Приводится сравнительный анализ контрольного и
опытных образцов рубленых полуфабрикатов в натуральной оболочке, оптимальная
рецептура разработанного рубленого полуфабриката с применением цитрусовых волокон,
органолептическая оценка полуфабриката и готового изделия.
Клініко-епідеміологічна характеристика вогнепальних поранень грудної клітки у військовослужбовців під час проведення АТО/ООС
Authors: Zarutskiy Ya. L. , Tkachenko A. Ye. , Vovk M. S. 
Published: April 2021

Вступ. Вогнепальні поранення грудної клітки під час проведення АТО/ООС становлять 7,4 – 11,7%. При цьому летальність залишається доволі високою – 12,2 – 25%. Тяжкість поранення, хірургічна тактика та результат лікування залежать від його балістичних та анатомо-морфологічних характеристик. Тому, проведення клініко-епідеміологічного дослідження щодо поранень грудної клітки у військовослужбовців під час АТО/ООС дозволить обирати адекватну діагностично-лікувальну тактику та розрахувати необхідні сили і засоби медичної служби.
Мета роботи. Провести клініко-епідеміологічне дослідження вогнепальних поранень грудної клітки під час АТО/ООС та визначити фактори, які впливають на тяжкість травми.
Матеріали та методи. Проведений аналіз лікування 536 поранених з вогнепальним ушкодженням грудної клітки, що перебували у ВМКЦ Північного регіону (м. Харків), Національному військово-медичному клінічному центрі "ГВКГ" (м. Київ) в період бойових дій на Сході України з 2014 по 2016 рік.
Результати. У структурі поранень грудної клітки переважали осколкові – 387 (72,2%). Вибухові поранення виявлені у 94 (17,5%) постраждалих, кульові у 55 (10,3%). Серед осколкових поранень питома вага непроникаючих була найбільшою – 80,9% (n=313), тоді як серед вибухових та кульових – переважали проникаючі: 62,8% (n=59) та 61,5% (n=34) відповідно. При проникаючих пораненнях ушкодження внутрішніх органів зустрічалися у ¾ пацієнтів. З легкою травмою було 143 (26,8%) поранених, з травмою середньої тяжкості – 237 (44,2%), з тяжкою – 156 (29,1%). Найбільша частка поранених з тяжкою травмою була серед кульових поранень – 50,9% (n=28); серед вибухових та осколкових поранень: 26,6% (n=25) та 23,8% (n=92) відповідно. На основі мультиваріантного логістичного регресійного аналізу встановлено, що характер поранення «кульове» (Wald=14,1; р=0,00), поєднаний (Wald=4,67; р=0,03) та проникаючий характер (Wald=7,94; р=0,005) є незалежними факторами ризику тяжкого поранення.
Висновки. Під час АТО/ООС осколкові поранення грудної клітки становили – 72,2%; вони переважно мали множинний характер – 77,8%, але питома вага тяжких – 23,8% та проникаючих – 19,1% поранень серед них відносно невелика. Кульові поранення зустрічалися у 10,3%; вони несли високу ймовірність проникаючого характеру – 61,5%, та тяжкого поранення – 50,9%. Вибухові поранення умовно займали проміжне становище: їх частка – 17,5%; проникаючих та тяжких із них: 62,8% і 26,6% відповідно.
Patologi Birokrasi Dalam Pelayanan Pengurusan Paspor Di Kantor Imigrasi Kelas 1 Kota Makassar
Authors: Fitra Ramadani Eka , Karim Musliha , Burhanuddin Burhanuddin 
Published: April 2021

Banyaknya pengaduan masyarakat berupa pelayanan yang berlarut-larut, mempersulit, diskriminasi pelayanan dan lamanya waktu penyelesaian pelayanan di Kantor Imigrasi Kelas 1 Kota Makassar menunjukkan adanya patologi birokrasi yang terjadi. Oleh karena itu, penelitian ini bertujuan untuk mengetahui patologi yang terdapat dalam pelayanan pengurusan paspor di Kantor Imigrasi Kelas 1 Kota Makassar. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif kualitatif. Tipe penelitian adalah fenomenologis. Teknik pengumpulan data yang digunakan adalah studi pustaka dan studi lapangan (observasi, wawancara, dan dokumentasi). Teknik penentuan informan dengan menggunakan purposive sampling. Hasil penelitian patologi birokrasi dalam pelayanan pengurusan paspor di Kantor Imigrasi Kelas 1 Kota Makassar, menunjukkan masih adanya perilaku negatif dalam hal ini patologi birokrasi dalam memberikan pelayanan seperti, penyalahgunaan wewenang, yang terdiri pemanfaatan kekuasan dan jabatan, dan memperlambat proses penyelesaian. Diskriminasi, seperti perbandingan promordialisme, satu almamater, status sosial, dan status kekeluargaan. Upaya untuk mengurangi terjadinya patologi birokrasi yang terdiri dari: pendisiplinan pegawai, yaitu kehadiran yang tepat waktu, dan menjunjung etos kerja serta peningkatan pengawasan, seperti sumber daya manusia (SDM) yang memadai, dan penerapan budaya organisasi yang optimal.
Drilling the Aptian–Albian of the Sergipe–Alagoas Basin, Brazil: paleobiogeographic and paleoceanographic studies in the South Atlantic
Authors: Fauth Gerson , Bruno Mauro Daniel Rodrigues , Villegas-Martín Jorge , Savian Jairo Francisco , Guerra Rodrigo do Monte , Krahl Guilherme , Lima Francisco Henrique de Oliveira , Strohschoen Jr. Oscar , Mello Raquel Gewehr de , Lopes Fernando Marcanth , Leandro Carolina Gonçalves , Aguiar Eduardo da Silva 
Published: April 2021

Abstract. The Aptian–Albian interval is characterized by significant paleoclimatic, paleoceanographic, and paleogeographic changes, which in turn affected the distribution and evolution of marine ecosystems. Despite the importance of such studies, there have been few correlations between Aptian–Albian sections of the Tethys Sea and those of the South Atlantic Ocean. This interval, including the Aptian–Albian transition, is preserved in the deposits of the Riachuelo Formation (Sergipe–Alagoas Basin, Brazil) located in the South Atlantic Ocean; therefore, this location was chosen for drilling four new cores. The goals of this paper are as follows: (1) to explain the drilling operation carried out in the deposits of the Riachuelo Formation and the methods used; (2) to present a brief lithostratigraphic characterization of the holes and the paleomagnetic data of core SER-03; and (3) to describe the high potential of the cores recovered for additional investigation in the future. The lithostratigraphic units of the SER-01 core consist mainly of coarse- to fine-grained sandstone, shales, marls, and mudstones; the SER-02 core was excluded due to low recovery; the SER-03 core is mainly composed of fine-grained sediments (shale, marls, and packstone) and bears some ammonite shells; the lithology of core SER-04 is mainly sandstones. Magnetic susceptibility values (χlf and χhf) and frequency-dependent susceptibility (χfd) data suggest that the section is located within the Cretaceous Normal Superchron. Future studies on these cores integrating micropaleontological, paleoichnological, geochemical, stratigraphic, and paleomagnetic (e.g., relative intensity) data will allow for a better understanding of paleoceanographic and paleogeographic events related to the early evolution of the South Atlantic Ocean and how these events correlate to similar events in Tethyan sections.
Indonesian Learning Through WhatsApp Group To Create Interactive Learning Conditions
Authors: Santoso Sugeng , Dewi Ni Komang Sarini 
Published: April 2021

Abstract: This research aims to use WhatsApp group to Indonesian learning in VIII class students at UPT SMP Negeri 3 Ponggok. This research used qualitative approach because it uses data in the form of words. At the same time, this research used experimental type because it is testing something. The research subjects were from VIII-D class students, and the object was Indonesian learning through WhatsApp group. The data collection techniques were observation, documentation, and questionnaires. Comparative analysis will be processed after the data is obtained. In addition, the analysis was also carried out with Miles and Huberman's technique. Miles and Huberman's technique has several stages; data reduction, data presentation, and drawing conclusions. The research resulted the use of WhatsApp group was more interactive and fun than another method that has been implemented before. Therefore it is increasing student learning outcomes.
Keywords: Indonesian, interactive learning, WhatsApp group
Campus No. 5
Authors: Editor El 
Published: April 2021

It contains: UCA FEST: "United for culture" ;U Social Business Innovation ; III Congress of Human Talent Management Five key factors for the creation of business value ; Chair of support for microenterprise ; Chair of Accounting and Auditing ; Global Money Week ; Conference on Business Reflection, Business & Society ; Honorable Mention to the best graduation jobs of Bachelor's degrees in Business Administration and Bachelor of Marketing ; Launch web site Revista Reality Empresarial.
Realidad Empresarial No. 5, 2018: 51-57
Effect of Friction Pressure on Microstructure and Properties of Friction Welded Joints of Pure Aluminum/304 Stainless Steel
Authors: ZHAO Lizhe , GONG Wenbiao , ZHU Rui , GONG Mingyue , CUI Heng 
Published: April 2021

Continuous drive friction welding was used to realize the high quality connection between pure aluminum and 304 stainless steel. The composition of interface micro-zone and mechanical properties of joint were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), tensile test and hardness test. The formation mechanism of intermetallic compound (IMC) during friction welding was discussed. The results show that under the experimental parameters, the joint surface is uneven and two intermetallic compounds, Fe2Al5 and FeAl3, are formed. With the increase of friction pressure, the mechanical bonding degree of the joint decreases, the metallurgical bonding degree increases, the element diffusion distance increases from 1.4 to 1.9 um, the tensile strength of the joint can reach or even higher than that of the base metal on the aluminum side, and the maximum hardness increased from 414 HV to 447 HV.