bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Sieben Plagen auf einmal schlagen“ – Theatrale Hygienepropaganda und Infektionskrankheiten in der Sowjetunion der 1920 er–40 er Jahre**
Authors: Polianski Igor J. , Tutorskaya Maria , Kosenko Oxana 
Published: February 2021

AbstractThis paper explores the role and impact of the official Soviet hygiene propaganda during the first three decades after the October Revolution, taking as an example theatrical performances about infectious diseases. In the Bolshevik Great Experiment of the 1920s–30s, the creation of a “Soviet body” optimized according to aesthetic and medical‐hygienic norms was one of the core parts of the socialist project. For that purpose, hygiene campaigns were organized to promote hygiene and cleanliness with posters, leaflets, mobile exhibitions and lectures. Moreover, starting in the 1920s the theatrical performances were demonstrated in open‐air theatres and clubhouses for workers and farmers. Even in the kolkhoz fields agitprop‐revues, agit‐trials, living newspapers and didactic plays were performed. Many of them addressed the issues of epidemics. To popularize medical knowledge, special theatres of sanitary education were opened in Moscow and other cities of the country in the mid‐1920s–30s. Using archival materials of the Moscow Theatre for Sanitary Culture (1925–1947), the article shows theatrical techniques for producing evidence used in performances, bacteriological coding of political antagonisms on sanitary stages and transformations of everyday cultural practices in theatrical hygiene propaganda.
In‐silico media optimization for continuous cultures using genome scale metabolic networks: The case of CHO‐K1
Authors: Pérez‐Fernández Bárbara A. , Fernandez‐de‐Cossio‐Diaz Jorge , Boggiano Tammy , León Kalet , Mulet Roberto 
Published: February 2021

AbstractThe cell culture is the central piece of a biotechnological industrial process. It includes upstream (e.g. media preparation, fixed costs, etc.) and downstream steps (e.g. product purification, waste disposal, etc.). In the continuous mode of cell culture, a constant flow of fresh media replaces culture fluid until the system reaches a steady state. This steady state is the standard operation mode which, under very general conditions, is a function of the ratio between the cell density and the dilution rate and depends on the media supplied to the culture. To optimize the production process it is widely accepted that the concentration of the metabolites in this media should be carefully tuned. A poor media may not provide enough nutrients to the culture, while a media too rich in nutrients may be a waste of resources because, either the cells do not use all of the available nutrients, or worse, they over‐consume them producing toxic byproducts. In this study, we show how an in‐silico study of a genome scale metabolic network coupled to the dynamics of a chemostat could guide the strategy to optimize the media to be used in a continuous process. Given a known media we model the concentrations of the cells in a chemostat as a function of the dilution rate. Then, we cast the problem of optimizing the production process within a linear programming framework in which the goal is to minimize the cost of the media keeping fixed the cell concentration for a given dilution rate in the chemostat. We evaluate our results in two metabolic models: first a simplified model of mammalian cell metabolism, and then in a realistic genome‐scale metabolic network of mammalian cells, the Chinese hamster ovary cell line. We explore the latter in more detail given specific meaning to the predictions of the concentrations of several metabolites.
Reverse logistics, organizational culture and firm operational performance: Some empirical evidence
Authors: Saruchera Fanny , Asante‐Darko Disraeli 
Published: February 2021

AbstractAs the supply chain environment is increasingly becoming uncertain and globally competitive, reverse logistics (RL) practices, which constitute a substantial component of Green Supply Chain Management (GSCM), have been widely recognized as crucial in achieving sustainable competitive advantage. While past studies have proven the positive relationship between properly implemented RL and firm's environmental efficiency and overall competitiveness, developing, maintaining, and integrating RL into the organization's supply chain operations come at a cost and institutional commitment. This study seeks to provide evidence on how RL and organizational culture (OC) provide benefits specifically to the operational performance (OP) of an organization. The study addresses this, first, by an empirical examination of the direct effects of RL practices on firm OP and, then, by further examining whether RL practices' influence on OP is strengthened by OC. The study uses dataset gathered from 213 firms across the service and manufacturing sectors in the Ghanaian economy using a structured questionnaire. The study adopts confirmatory factor analysis (CFA) in addition to partial least square structural equation modelling (PLS‐SEM) in analysing the study's measurement model and in estimating the resultant structural model. The study concludes that implementing RL practices positively influences the OP of the firm, while OC strengthens such influence. This study expands the RL literature by obtaining the results for the conceptual model and dealing with the implication from a developing economy's perspective, hence supplementing the growing body of knowledge.
Holistic representation in juvenile defense: An evaluation of a multidisciplinary children's defense team
Authors: Phillippi Stephen , Thomas Casey L. , Yoshida Yilin , Afaneh Hasheemah 
Published: February 2021

AbstractThis study describes the results of an evaluation of a holistic defense model for juvenile clients. Longitudinal, retrospective analysis of de‐identified data from clients (N = 308) measured individual variable outcomes, relationships, and project performance. Bivariate and multivariate analyses examined the strength of association and interrelationships among client and defense team variables. Findings indicate that holistic defense was significantly associated with improved outcomes among juvenile clients, including increased mental health assessment resulting in treatment, increased employment and educational attainment, and decreased odds of recidivism. Favorable court or dispositional outcomes, including lower adjudication or early termination from custody, were also reported. Further practice‐level, controlled research is necessary to evaluate these models and offer comparison to other models for holistic defense.
A phase 2 trial of trifluridine/tipiracil plus nivolumab in patients with heavily pretreated microsatellite‐stable metastatic colorectal cancer
Authors: Patel Manish R. , Falchook Gerald S. , Hamada Kensuke , Makris Lukas , Bendell Johanna C. 
Published: February 2021

AbstractBackgroundMicrosatellite‐stable (MSS) colorectal cancer (CRC) tends to be poorly immunogenic, with limited treatment options. In MSS CRC xenograft models, trifluridine/tipiracil (FTD/TPI) plus programed death 1 inhibitors resulted in synergistic antitumor activity and increased tumor immunogenicity. This phase 2 study evaluated FTD/TPI plus nivolumab in patients with MSS metastatic CRC.MethodsThis single‐arm, safety lead‐in study used a Simon's two‐stage design (enrolling 6 patients in the safety lead‐in, proceeding to stage 2 if ≥2 of the first 15 patients achieved a partial or complete response per immune‐related response criteria [irRC] within 6 months). Patients with histologically proven MSS mCRC, and disease progression after ≥2 prior chemotherapy regimens received FTD/TPI (35 mg/m2 twice daily; days 1–5 and 8–12 every 28 days) plus nivolumab (3 mg/kg every 2 weeks).ResultsBetween August 2016 and January 2017, 18 patients (50% men; median age 56.5 years) were enrolled; 72% had colon cancer and 56% had KRAS mutations. All patients received treatment (median, 2.5 cycles [range, 1–8]). No dose‐limiting toxicities were observed in the study. The most frequent adverse events (AEs) of any cause and grade were nausea (67%), diarrhea (61%), and neutropenia (50%); 13 patients (72%) experienced grade ≥3 AEs. No patients discontinued treatment because of AEs. No patient achieved a tumor response (either per Response Evaluation Criteria in Solid Tumors [RECIST] or irRC), and the study did not progress to the second stage. Stable disease was achieved in 8 patients per irRC and in 10 patients per RECIST. Median progression‐free survival was 2.2 months (95% CI, 1.8–6.0 months) per irRC and 2.8 months (95% CI, 1.8–5.1 months) per RECIST.ConclusionPatients with refractory MSS metastatic CRC failed to experience clinical benefit with FTD/TPI plus nivolumab, although safety data in this population indicated tolerability and feasibility of this combination.Trial registration numberNCT02860546.
Modeling crowd emotion from emergent event video
Authors: Zhuo Lin , Liu Zhen , Liu Tingting , Hung Chih‐Chieh , Chai Yanjie 
Published: February 2021

AbstractIn emergency situation, mass panic often causes more causalities than the disaster itself. The crowd emotional model could be used to simulate how crowd behavior in emergency scenarios and be helpful for developing crowd evacuation plans in emergency situations. However, existing crowd emotional models usually set model parameters in an empirical manner and are not validated by real cases. In this paper, a crowd emotional model is proposed to simulate the crowd movement in outdoor emergency situations. First of all, the crowd entropy and the movement difference are proposed to describe the emotional impact of the crowd scene on the agents. The perception of vision and hearing are considered, and the calculation formulas of the agent's emotional intensity and crowd emotional contagion are proposed. By calculating individual trajectories in the real video, the cumulative differences between the movements of the real crowd and the corresponding virtual crowd are analyzed. At last, a multi‐parameter optimization method is implemented by the differential evolution algorithm. To verify the parameters in models, three videos which are generated from three real cases, including explosion attack, shooting incident, and crowd disturbance are selected for experimental verification. The results showed that the proposed model could be a feasible method for optimizing parameters to simulate the emergency scenario.
Westalsan: A New Acetylcholine Esterase Inhibitor from the Endophytic FungusWesterdykella nigra
Authors: Sallam Amal , Sabry Mohamed A. , Galala Amal A. 
Published: February 2021

AbstractA new cytochalasan alkaloid, westalsan (1), along with two known cytochalasan compounds, phomacin B (2) and 19‐hydroxy‐19,20‐dihydrophomacin C (3), were isolated from the solid rice culture ofWesterdykella nigra, a marine‐derived endophytic fungus, isolated from the roots of mangroveAvicennia marina(Forssk.) Vierh. The structures of compounds1–3were established on the basis of extensive 1D and 2D NMR spectroscopic techniques in combination with HR‐ESI‐MS. The ability of the isolated compounds to inhibit acetylcholine esterase activity was evaluated. Compound3showed the highest acetylcholine esterase inhibitory activity (IC500.056±0.003 μM), followed by compound1(IC500.088±0.005 μM) and compound2(IC500.140±0.007 μM) compared to donepezil (IC500.035±0.002 μM). This was further confirmed by molecular docking experiment.
Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase
Authors: Vitiello Simone , Caselli Monica , Pavesi Giorgia , Santucci Matteo , Ferrari Stefania , Paola Costi Maria , Ponterini Glauco 
Published: February 2021

AbstractThe observables associated with protein intrinsic fluorescence – spectra, time decays, anisotropies – offer opportunities to monitor in real time and non‐invasively a protein‘s functional form and its interchange with other forms with different functions. We employed these observables to sketch the fluorometric profiles of two functional forms of human thymidylate synthase (hTS), a homodimeric enzyme crucial for cell proliferation and thus targeted by anticancer drugs. The protein takes an active and an inactive form. Stabilization of the latter by peptides that, unlike classical hTS inhibitors, bind it at the monomer/monomer interface offers an alternative inhibition mechanism that promises to avoid the onset of drug resistance in anticancer therapy. The fluorescence features depicted herein can be used as tools to identify and quantify each of the two protein forms in solution, thus making it possible to investigate the kinetic and thermodynamic aspects of the active/inactive conformational interchange. Two examples of fluorometrically monitored interconversion kinetics are provided.
GPR39 promotes cardiac hypertrophy by regulating the AMPK–mTOR pathway and protein synthesis
Authors: Liao Hongjuan , Gao Weinian , Ma Jie , Xue Hongyuan , Wang Yi , Huang Dai , Yan Fang , Ye Yuquan 
Published: February 2021

AbstractHypertrophic growth of the cardiomyocytes is one of the core mechanisms underlying cardiac hypertrophy. However, the mechanism underlying cardiac hypertrophy remains not fully understood. Here we provided evidence that G protein‐coupled receptor 39 (GPR39) promotes cardiac hypertrophy via inhibiting AMP‐activated protein kinase (AMPK) signaling. GRP39 expression is overexpressed in hypertrophic hearts of humans and transverse aortic constriction (TAC)‐induced cardiac hypertrophy in mice. In neonatal cardiomyocytes, adenovirus‐mediated overexpression of GPR39 promoted angiotensin II‐induced cardiac hypertrophy, while GPR39 knockdown repressed hypertrophic response. Adeno‐associated virus 9‐mediated knockdown of GPR39 suppressed TAC‐induced decline in fraction shortening and ejection fraction, increase in heart weight and cardiomyocyte size, as well as overexpression of hypertrophic fetal genes. A mechanism study demonstrated that GPR39 repressed the activation of AMPK to activate the mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase β‐1 (S6K1), subsequently promoted de novo protein synthesis. Inhibition of mTOR with rapamycin blocked the effects of GPR39 overexpression on protein synthesis and repressed cardiac hypertrophy. Collectively, our findings demonstrated that GPR39 promoted cardiac hypertrophy via regulating the AMPK–mTOR–S6K1 signaling pathway, and GRP39 can be targeted for the treatment of cardiac hypertrophy.
An ultra‐low‐profile 0.85 mm Nano Hydro balloon to treat wire‐crossable balloon‐uncrossable lesions: A useful tool in CTO armamentarium
Authors: Adusumalli Srikanth , Dautov Rustem 
Published: February 2021

AbstractBalloon uncrossable lesions are commonly encountered during chronic total occlusion (CTO) percutaneous coronary intervention (PCI). A sequential strategy and planning are required to tackle such lesions. We present a case series of severely calcified, device uncrossable lesions where the traditional strategies failed and an ultra‐low‐profile (0.85 mm) balloon was crucial to successful PCI. To our best knowledge, this is the first case series describing the use of this balloon in real world.
Outcomes of in‐hospital cardiac arrest in COVID‐19 patients: A proportional prevalence meta‐analysis
Authors: Mir Tanveer , Sattar Yasar , Ahmad Javeed , Ullah Waqas , Shanah Layla , Alraies M Chadi , Qureshi Waqas T. 
Published: February 2021

AbstractBackgroundLimited epidemiological data are available on the outcomes of in‐hospital cardiac arrest (CA) in COVID‐19 patients.MethodsWe performed literature search of PubMed, EMBASE, Cochrane, and Ovid to identify research articles that studied outcomes of in‐hospital cardiac arrest in COVID‐19 patients. The primary outcome was survival at discharge. Secondary outcomes included return of spontaneous circulation (ROSC) and types of cardiac arrest. Pooled percentages with a 95% confidence interval (CI) were calculated for the prevalence of outcomes.ResultsA total of 7,891 COVID patients were included in the study. There were 621 (pooled prevalence 8%, 95% CI 4–13%) cardiac arrest patients. There were 52 (pooled prevalence 3.0%; 95% CI 0.0–10.0%) patients that survived at the time of discharge. ROSC was achieved in 202 (pooled prevalence 39%;95% CI 21.0–59.0%) patients. Mean time to ROSC was 7.74 (95% CI 7.51–7.98) min. The commonest rhythm at the time of cardiac arrest was pulseless electrical activity (pooled prevalence 46%; 95% 13–80%), followed by asystole (pooled prevalence 40%; 95% CI 6–80%). Unstable ventricular arrhythmia occurred in a minority of patients (pooled prevalence 8%; 95% CI 4–13%).ConclusionThis pooled analysis of studies showed that the survival post in‐hospital cardiac arrest in COVID patients is dismal despite adequate ROSC obtained at the time of resuscitation. Nonshockable rhythm cardiac arrest is commoner suggesting a non‐cardiac cause while cardiac related etiology is uncommon. Future studies are needed to improve the survival in these patients.
Thermal exposure values for predicting changes in rice end‐use properties during drying
Authors: Graham‐Acquaah Seth , Siebenmorgen Terry J. , Mauromoustakos Andronikos , Wang Ya‐Jane 
Published: February 2021

AbstractBackground and objectivesRough rice may incur various degrees of thermal exposure during heated‐air drying, which may cause variations in end‐use properties. This study employed a recently proposed method to quantify thermal exposure incurred during drying and its effects on rice end‐use properties.FindingsGreater drying air temperatures and longer drying durations increased thermal exposure (GATE) values; the higher the GATE value, the more moisture lost during drying. Increasing GATE values reduced head rice yield (HRY). The most notable (≥10%) reductions in HRY occurred when GATE values were ≥30 min. Additionally, increasing GATE values increased peak and breakdown viscosities of rice but decreased both setback viscosity and rice gel strength; the impact of drying on end‐use properties was of most practical importance (≥10% change) when GATE values were ≥40 min.ConclusionsThe proposed GATE values would permit comparisons of the effects of thermal exposure on rice milling and end‐use properties to facilitate predictions of changes in these properties due to heated‐air drying.Significance and noveltyDifferences in heated‐air drying conditions contribute to the inconsistencies in functionality that hinder the wide use of rice in end‐use, gluten‐free product development. This study shows that thermal exposure (GATE) values could be useful for quantifying and comparing cumulative heat‐exposure during drying to facilitate predictions of changes in rice properties.
Prolonged encephalopathy and associated nonconvulsive seizures from suspected pregabalin and tapentadol: Two case reports and review of literature
Authors: Haji Kavi , Muthu Sachin , Banakh Iouri , Tiruvoipati Ravindranath 
Published: February 2021

AbstractA combination of pregabalin and tapentadol may be associated with prolonged encephalopathy.
Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
Authors: Shiraiwa Ken , Ono Hiroyuki , Tanaka Ryota , Fujinaga Atsuro , Hiratsuka Takahiro , Tatsuta Ryosuke , Inomata Masafumi , Itoh Hiroki 
Published: February 2021

AbstractDrug‐drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S‐1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.
Mononuclear Dysprosium Alkoxide and Aryloxide Single‐Molecule Magnets
Authors: Parmar Vijay S. , Mills David P. , Winpenny Richard E. P. 
Published: February 2021

AbstractRecent studies have shown that mononuclear lanthanide (Ln) complexes can be high‐performing single‐molecule magnets (SMMs). Recently, there has been an influx of mononuclear Ln alkoxide and aryloxide SMMs, which have provided the necessary geometrical control to improve SMM properties and to allow the intricate relaxation dynamics of Ln SMMs to be studied in detail. Here non‐aqueous Ln alkoxide and aryloxide chemistry applied to the synthesis of low‐coordinate mononuclear Ln SMMs are reviewed. The focus is on mononuclear DyIII alkoxide and aryloxide SMMs with coordination numbers up to eight, covering synthesis, solid‐state structures and magnetic attributes. Brief overviews are also provided of mononuclear TbIII, HoIII, ErIII and YbIII alkoxide and aryloxide SMMs.
Designed Construction of SrTiO3/SrSO4/Pt Heterojunctions with Boosted Photocatalytic H2 Evolution Activity
Authors: Cai Jingyi , Wei Haoshan , Zhang Yong , Cai Rui , Zhang Xueru , Wang Yan , Liu Jiaqin , Tan Hark Hoe , Xie Ting , Wu Yucheng 
Published: February 2021

AbstractEfficient separation of photogenerated electron–hole pairs is a crucial factor for high‐performance photocatalysts. Effective electron–hole separation and migration could be achieved by heterojunctions with suitable band structures. Herein, a porous SrTiO3/SrSO4 heterojunction is prepared by a sol‐gel method at room temperature followed by an annealing process. XRD characterization suggests high crystallinity of the heterostructure. A well‐defined interface between the two phases is confirmed by high‐resolution (HR)TEM. The photocatalytic H2 evolution productivity of the SrTiO3/SrSO4 heterojunction with Pt as co‐catalyst reaches 396.82 μmol g−1 h−1, which is 16 times higher than that of SrTiO3/Pt. The boosted photocatalytic activity of SrTiO3/SrSO4/Pt can be ascribed to the presence of SrSO4, which promotes the transfer and migration of photogenerated carriers by forming the heterojunction and porous structure, which provides a large amount of active sites. This novel porous heterostructure brings new ideas for the development of high‐efficiency photocatalysts for H2 release.
The Role of the −OH Groups within Mn12Clusters in Electrocatalytic Water Oxidation
Authors: Gluz Naama , Christou George , Maayan Galia 
Published: February 2021

AbstractThe formidable reactivity of the oxygen‐evolving center near photosystem II is largely based on its protein environment that stabilizes it during catalysis. Inspired by this concept, the water‐solubleMn12clusters Mn12O12(O2CC6H3(OH)2)16(H2O)4(3,5DHMn12) and Mn12O12(O2CC6H3(OH)3)16(H2O)4(3,4,5THMn12) were developed as efficient electrocatalysts for water oxidation. In this work, the role of the −OH groups in the electrocatalytic process was explored by describing the structural and electrocatalytic properties of two newMn12clusters,3,4DHMn12and2,3DHMn12, having one −OH group in themetaposition relative to the benzoate‐Mn moiety, and one at theparaororthoposition, respectively. The Mn centers in3,4DHMn12were discovered to have lower oxidation potential compared with those in2,3DHMn12, and thus,3,4DHMn12can catalyze water oxidation with higher rate and TON than2,3DHMn12. Hence, the role of the −OH groups in the electrocatalysis was established, being involved in electronic stabilization of the Mn centers or in proton shuttling.