bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strain Analysis Using Feature Tracking Cardiac Magnetic Resonance Predict Prognosis of Patients With Ventricular Aneurysm After Myocardial Infarction
Authors: Shen Song , Liang Jing , Li Jianhui , Bao Xue , Xie Jun , Xu Biao , Wei Zhonghai , wang Kun , Dai Qing , Wang Lian , Zhang Jilei , mu Dan , Li Qiaoling 
Published: October 2021

Abstract
Objective We aim to assess the left ventricular strain in patients with ventricular aneurysm(VA) after myocardial infarction(MI) using cardiac magnetic resonance-feature tracking (CMR-FT) and to evaluate its value for long term prognosis of patients.Methods Sixty-five patients who underwent CMR with VA after MI from January 2018 to December 2019 in Drum Tower Hospital Affiliated Hospital of Nanjing University School of Medicine were selected for the study. They were divided into two groups based on New York Heart Association (NYHA): 25 cases of NYHA I as group A and 40 cases of NYHA II-IV as group B. CMR was performed in both groups to quantify the parameters of overall and segmental left ventricular myocardial strain in patients with aneurysm. 37 of whom underwent a second CMR 3-12 months after cardiac infarction to investigate the effects of aneurysm on patients' left ventricular strain and left ventricular cardiac function.Results Patients from group B have larger VA basilar transverse diameter and significant more impaired LV Global longitudinal strain(GLS)、Global circumferential strain(GCS)、Global radial strain(GRS) (-12.34±7.31 vs. -7.68±6.11;p=0.0072, -21.31±13.49 vs. -14.93±10.44;p=0.0361, 37.13±27.87 vs. 22.00±20.05;p=0.0135) without change in infarct size. GLS, GCS, GRS were significant indicators of NYHA classification after AMI by multivariate regression analysis.Conclusions Myocardial strain assessed by CMR-FT may be an independent predictor of NYHA of patients with aneurysm after MI and could be used for identifying high-risk patients with VA.
Evaluating The Performance Characteristics of Five Lateral Flow Assays for The Detection of The SARS- CoV-2 Nucleocapsid Antigen
Authors: Heskin Joseph , Pallett SJC , Al-Hindawi A , Davies GW , Rayment M , Mughal N , Randall P , Jones R , Moore LSP 
Published: October 2021

Abstract
Introduction: In response to the COVID-19 pandemic, lateral flow assays (LFAs) for the detection of SARS-CoV-2 antigen have been proposed as a complementary option to the more costly and time consuming reverse-transcriptase polymerase chain reaction (RT-PCR). We assessed five commercially available SARS-CoV-2 antigen detecting LFAs (ASSUT EUROPE (Rome, Italy), Besthree (Taizhou, China), Encode (Zhuhai, China), Fortress (Antrim UK), and Hughes Medical (Buckinghamshire, UK), using samples collected from hospitalised individuals with COVID-19 and compared these results against established RT-PCR assays with the aim of estimating test performance characteristics.Method: We performed a diagnostic accuracy study of the LFAs on 110 inpatients with confirmed COVID-19 and 75 COVID-19 negative control participants. Assay evaluation was performed using a modified version of each manufacturer’s protocol allowing for parallel testing of a single sample on multiple assays.Results: Half (46%, 51) of the patient cohort were in the higher risk age category (>70 years old). Community acquisition of SARS-CoV-2 accounted for 77% (85) of our positive cohort with the remaining 23% (25) resulting from nosocomial transmission. The sensitivity of the LFAs ranged from 64% (95% CI 53-73) to 76% (95% CI 65-85). Of the assays tested, Fortress performed best with a sensitivity of 76% (95% CI 65-85). Specificity based on testing SARS-CoV-2 volunteers was high across all assays with four of the five achieving 100%Conclusion: SARS-CoV-2 antigen detecting LFAs may complement RT-PCR testing to facilitate early diagnosis and provide community testing strategies for identification of patients with COVID-19, however we find suboptimal test performance characteristics across a range of commercially available manufacturers, below WHO and MHRA pre-set sensitivity performance thresholds. With such variation in sensitivity between LFAs and PCR testing and between assay brands, we advise caution in the deployment of LFAs outside of environments with clinical oversight.
SARS-CoV-2 Host Prediction Based on Virus-host Genetic Features
Authors: Kawashima Irina Yuri , Lopez Maria Claudia Negret , Cunha Marielton dos Passos , Hashimoto Ronaldo Fumio 
Published: October 2021

Abstract
The genetic diversity of the Coronaviruses gives them different biological abilities, such as infect different cells and/or organisms, a wide spectrum of clinical manifestations in a single host, their different routes of dispersion, and viral transmission in a specific host. In recent decades, different Coronaviruses have emerged that are highly adapted for humans and causing serious diseases, leaving their host of unknown origin. The viral genome information is particularly important to enable the recognition of patterns linked to their biological characteristics, such as the specificity in the host-parasite relationship. Here, based on a previously computational tool, the seq2host, we developed a novel approach which uses new variables obtained from the frequency of spike-Coronaviruses codons, the Relative Synonymous Codon Usage (RSCU) to shed new light on the molecular mechanisms involved in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host specificity. By using the RSCU obtained from nucleotide sequences before the SARS-CoV-2 pandemic, we assessed the possibility of know the hosts capable to be infected by these new emerging species, which was first identified infecting humans during 2019 in Wuhan, China. According to the tool trained and validated using sequences available before the pandemic, bats are the most likely susceptible host to the SARS-CoV-2 infection, as previously suggested in other studies that searched for the host viral origin.
Patients’ and family caregivers’ experiences and perceptions about factors hampering or facilitating patient empowerment for self-management of hypertension and diabetes in Cameroon: Evidence from thematic and lexicometric analyses of qualitative study data
Authors: Mogueo Amélie , DEFO BARTHELEMY KUATE 
Published: October 2021

Abstract
BackgroundNoncommunicable diseases like hypertension and diabetes require long-term management, and are financially draining for patients and their families bearing the treatment costs, especially in settings where the inadequacy or non-existence of the health insurance system prevails. Patient empowerment-focused interventions have been shown to improve adherence to therapeutic regimens and decrease unnecessary health care utilization and costs. This study aims to examine enabling and impeding factors to the development of patient empowerment in a resource-limited setting like Cameroon. MethodsWe used qualitative methods entailing three levels of investigation and involving a public primary healthcare hospital in Yaoundé, Cameroon. Data were collected through 40 semi-structural interviews with patients having hypertension or diabetes and their family caregivers, one focus group discussion with six patients, 29 observations of consultations of patients by specialist physicians, seven observations of care received by inpatients from generalist physicians, and nine documents on the management of hypertension or diabetes. A novel approach combining thematic and lexicometric analyses was used to identify similarities and differences in barriers and facilitators associated with patient empowerment at different levels of the healthcare delivery system in Cameroon. ResultsBarriers generally outnumbered facilitators. There were particularities as well as commonalities in reported facilitators and barriers linked to patient empowerment from different experiences and perspectives of outpatients, inpatients and their family caregivers, given the healthcare services and organization of health personal and resources that deliver healthcare services to meet the health needs of patients with hypertension or diabetes in Cameroon. While specific factors identified by patients were directly related to the self-management of their disease at the individual level, family caregivers were mainly focused on factors present at organizational and central levels, which are indirectly related to the management of the diseases and beyond the control of patients and families. ConclusionsThe preponderance of individual-level factors linked to patient empowerment more than those at the central and hospital/organizational levels calls for due attention to them in the multilevel design and implementation of patient empowerment interventions in resource-limited settings like Cameroon. Accounting for patient’s and families’ perspectives and opinions may be key to improving healthcare delivery.
Multicenter Epidemiological Survey of Pneumatosis Intestinalis in Japan
Authors: Ohmiya Naoki , Hirata Ichiro , Sakamoto Hirotsugu , Morishita Toshifumi , Saito Eiko , Matsuoka Katsuyoshi , Nagaya Tadanobu , Nagata Shinji , Mukae Miyuki , Sano Koji , Suzuki Takayoshi , Tarumi Kenichi , Shimizu Seiji , Kawashima Kousaku , Hibi Toshifumi 
Published: October 2021

Abstract
Background

Pneumatosis intestinalis (PI) is a rare condition characterized by gas collection in the intestinal wall. We aimed to determine the etiology and affected segments associated with complications, treatment, and outcome.
Methods

We conducted a multicenter epidemiological survey using a standardized data collection sheet in Japan. Complicating PI was defined as strangulation or bowel necrosis, bowel obstruction, adynamic ileus, sepsis, shock, and massive gastrointestinal bleeding.
Results

We enrolled 167 patients from 48 facilities. Multivariate analysis revealed that older age (adjusted OR, 1.05 and 95% confidence intervals [CI], 1.02-1.09, P=0.0053) and chronic kidney disease (adjusted OR, 13.19 and 95% CI, 1.04-167.62, P=0.0468) were independent predictors of the small-bowel-involved type. Complicating PI was associated with the small-bowel-involved combined type (adjusted OR, 45.49 and 95% CI, 8.34-248.13, P<0.0001), the small-bowel-only type (adjusted OR, 7.90 and 95% CI, 1.92-32.56, P=0.0042), and allopurinol/benzbromaron (adjusted OR, 31.07 and 95% CI, 1.70-567.28, P=0.0204). Oxygen therapy was performed in patients with a past history of bowel obstruction (adjusted OR, 13.77 and 95% CI, 1.31-144.56, P=0.0288) and surgery was performed in patients with complicating PI (adjusted OR, 8.93 and 95% CI, 1.10-72.78, P=0.0408). Antihypertensives (adjusted OR, 12.28 and 95% CI, 1.07-140.79, P=0.0439) and complicating PI (adjusted OR, 11.77 and 95% CI, 1.053-131.526; P=0.0453) were associated with exacerbation of PI. The complicating PI was the only indicator of death (adjusted OR, 14.40 and 95% CI, 1.09-189.48, P=0.0425).
Discussion

This study provides evidence supporting the association between the small-bowel-involved type and complications and poor prognosis.
Change of Knee Cartilage Components in Stroke Patients with Genu Recurvatum Analyzed by Zero TE MR Imaging
Authors: LI Youwei , Gao Qiang , Liu Jingxin , Wen Qiping , Jia Shiqi , Tang Fen , Mo Linhong , Zhang Yuanfang , Zhai Mingchun , Chen Yukun , Guo Yue , Gong Weijun , Li Wenshan 
Published: October 2021

Abstract
-BACKGROUND: Genu recurvatum in stroke patient hemiplegia causes readily cumulative damage and degenerative changes of knee cartilage. It is important to detect early lesions of cartilage for appropriate treatment and rehabilitation.-PURPOSE: The purpose is to provide theoretical basis for early rehabilitation of hemiplegia patients. -STUDY TYPE: Cross-sectional study. -POPULATION: 39 Stroke patients with genu recurvatum and 9 healthy volunteers. -SEQUENCE: We used zero TE double echo imaging sequence. -ASSESSMENT: Analyze the water content in knee joint cartilage at 12 different sites of stroke patients with genu recurvatum using a method similar to porosity index. -STATISTICAL TESTS: Statistical analysis was performed using SPSS 17.0 statistical software. The mean ± standard deviation was used to represent the mean. The independent sample t test was used for all mean comparisons. When the data did not conform to the normal distribution or variance heterogeneity, the non-parametric test was used. P< 0.05 was considered statistically significant.-RESULTS: When compared hemiplegia limb vs. non-hemiplegia limb in patients, the ratio of deep/shallow free water content of the cartilages at the junction of the femur and anterior horn (1.16 vs. 1.06) and posterior horn (1.13 vs. 1.25) of lateral meniscus were significant differences (P<0.05). -DATA CONCLUSION: Conclusion is that Genu recurvatum in stroke patients with hemiplegia can cause changes in moisture content of knee cartilage, and the changes of knee cartilage are more obvious with the increase of genu recurvatum. The so-called "healthy limb" is no longer the real meaning of healthy limb, and should be considered simultaneously with the affected limb in the development of rehabilitation treatment plan.
Individual Differences in Decision-Making: Evidence for The Scarcity Hypothesis From The English Longitudinal Study of Aging
Authors: Tunney Richard J. , James Richard J.E. 
Published: October 2021

Abstract
We report the results of a pre-registered analysis of data from the English Longitudinal Study of Aging that was designed to test the hypothesis that economic scarcity is associated with individual differences in decision-making. We tested this hypothesis by comparing time preferences for different socio-economic groups and in geographical areas ranging from the most deprived to the least deprived in England using the English Indices of Multiple Deprivation. The data supported this hypothesis: People in the most deprived areas were more likely to prefer smaller sooner rewards than people from the least deprived areas. Similarly, people in technical or routine occupations tended to prefer smaller sooner rewards than people in professional or intermediate occupations. In addition, we found that gender, length of education, cognitive function, and subjective social status also predicted time preferences. We discuss these results in the context of theoretical models of scarcity-based models of choice behaviour and decision-making.
Correlation Between he Ratio Pipp-R and Nips and Inter-Rater Reliability to Evaluate Pain During the Procedure Suction in Newborn Premature
Authors: OLIVEIRA NAYARA RODRIGUES GOMES , FORMIGA CIBELLE MARTINS ROBERTO , RAMOS BRUNA ABREU , SANTOS RAFAELA NOLETO DOS , MOREIRA NAYARA NUBIA DE SOUSA , MARÇAL PATRICIA GONÇALVES EVANGELISTA , AMARAL WALDEMAR NAVES DO 
Published: October 2021

Abstract
Objectives:To verify the Correlation between the Neonatal Infant Pain Scale (NIPS) and Premature Infant Pain Profile – Revised (PIPP-R), the internal consistency of each scale, and assess the reliability between evaluators in the assessment of pain during the aspiration procedure in premature newborns. Methods: an observational, prospective study. Participated in the study, 50 infants who met the following criteria for inclusion: Newborn (NB) preterm (GA> 26 weeks and <36 weeks and five days) with low birth weight (<2500 g), hemodynamically stable, with minimal sedation or without sedation or mechanical ventilation in CPAP or catheter nose of O2 or the air environment that needed to perform the procedure of vacuum in the period of hospitalization. The evaluation of the newborns occurred during three different aspiration procedures; aspiration 1 (no intervention), aspiration 2 (use of gentle touch), and aspiration 3 (use of sucrose). They have applied two evaluation instruments, NIPS and PIPP-R. that Cronbach's alpha determined the internal consistency, reliability between evaluators by the coefficient of Correlation intraclass, validity competitor by Spearman test. Results: Internal Consistency was high for NIPS (r= 0.824) and moderate for PIPP-R (0.655). Reliability between raters was high respectively in the three conditions 0.991; 0.987; 0.993 on the NIPS scale and 0.997; 0.986; 0.977 on the PIPP-R scale. One observed concurrent validity Only in the first aspiration. Conclusion: the NIPS seems to have a better utility clinic than PIPP-R; however, the two scales showed good reliability among the evaluators, and internal consistency, being a good choice for evaluation of pain during the procedure of aspiration.
First-mover Advantage Explains Gender Disparities in Physics Citations
Authors: Kong Hyunsik , Martin-Gutierrez Samuel , Karimi Fariba 
Published: October 2021

Abstract
Mounting evidence suggests that publications and citations of scholars in the STEM fields (Science, Technology, Engineering and Mathematics) suffer from gender biases. In this paper, we study the physics community, a core STEM field in which women are still largely under-represented and where these gender disparities persist. To reveal such inequalities, we compare the citations received by papers led by men and women that cover the same topics in a comparable way. To do that, we devise a robust statistical measure of similarity between publications that enables us to detect pairs of similar papers. Our findings indicate that although papers written by women tend to have lower visibility in the citation network, pairs of similar papers written by men and women receive comparable attention when corrected for the time of publication. These analyses suggest that gender disparity is closely related to the first-mover and cumulative advantage that men have in physics and is not an intentional act of discrimination towards women.
The Temporal Relation Between Pain and Fatigue in Individuals Receiving Treatment for Chronic Musculoskeletal Pain
Authors: Yamada Keiko , Adams Heather , Ellis Tamra , Clark Robyn , Sully Craig , Lariviere Christian , Sullivan Michael J. L. 
Published: October 2021

Abstract
Objective: Numerous investigations have revealed significant relations between pain and fatigue in individuals with persistent pain conditions. However, the direction of influence between pain and fatigue remains unclear. Shortcomings of design and analytic approaches used in previous research limit the nature of conclusions that can be drawn about possible causal relations between pain and fatigue. The present study investigated the temporal relation between changes in pain and changes in fatigue in individuals with musculoskeletal pain enrolled in a 10-week behavioral activation intervention. On the basis of previous findings, it was hypothesized that analyses would yield support for a bi-directional relation between pain and fatigue. Methods: The study sample consisted of 104 individuals with chronic musculoskeletal pain participating in a 10-week standardized rehabilitation intervention. Measures of pain intensity and fatigue were completed pre-, mid-, and post-treatment. The three-wave data panel permitted examination of the direction of influence between pain and fatigue through the course of the intervention. A random-intercept cross-lagged panel model (RI-CLPM) was used to examine the temporal relation between pain and fatigue. Results: Consistent with previous research, cross-sectional analyses of pre-treatment data revealed significant correlations between measures of pain and fatigue. Significant reductions in pain and fatigue were observed through the course of treatment (d=.33 and d =.66, p < .001, respectively). RI-CLPM revealed that pain severity predicted later fatigue (pre to mid-treatment standardized path coefficient (β) = 0.55, p = 0.02; mid to post-treatment β = 0.36, p = 0.001); however, fatigue did not predict later pain severity.Conclusions: Discussion addresses the processes that might underlie the temporal relation between pain and fatigue. Clinical implications of the findings are also discussed.
Effect of Interleukin-1 Blockade with Anakinra on Leukocyte Count in Patients with ST-Segment Elevation Acute Myocardial Infarction
Authors: BUONO MARCO GIUSEPPE DEL , Damonte Juan Ignacio , Trankle Cory R , Kadariya Dinesh , Carbone Salvatore , Thomas Georgia K , Turlington Jeremy , Markley Roshanak , Canada Justin , Biondi-Zoccai Giuseppe , Kontos Michael C. , Tassell Benjamin W. Van , Abbate Antonio 
Published: October 2021

Abstract
Background. Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin 1-b regulates leukopoiesis and pre-clinical studies suggest that anakinra (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in myocardial infarction. However, the effect of IL-1 blockade with anakinra on leukocyte count in patients with STEMI is unknown. Methods. We reviewed the white blood cell (WBC) and differential count of 99 patients enrolled in a clinical trial of anakinra (n=64) versus placebo (n=35) for 14 days after STEMI. A complete blood cell count with differential count were obtained at admission, and after 72 hours, 14 days and 3 months.Results. After 72 hours from treatment, anakinra compared to placebo led to a statistically significant greater percent reduction in total WBC count (-35% [-48 to -24] vs -21% [-34 to -10], P=0.008), absolute neutrophil count (-48% [-60 to -22] vs -27% [-46 to -5], P=0.004) and to an increase in absolute eosinophil count (+50% [0 to +100] vs 0% [-50 to +62], P=0.022). These changes persisted while on treatment at 14 days and were no longer apparent at 3 months after treatment discontinuation. Conclusion. We found that in patients with STEMI IL-1 blockade with anakinra accelerates resolution of leukocytosis and neutrophilia. This modulation may represent one of the mechanisms by which IL-1 blockade improves clinical outcomes.
Reconstruction of the Distal Radioulnar Joint with Rib Perichondrium – Midterm Follow-Up
Authors: Muder Daniel , Vedung Torbjörn 
Published: October 2021

Abstract
BackgroundReconstruction of an osteoarthritic distal radioulnar joint (DRUJ) in patients with high physical demands and a long lifetime expectancy is challenging. A variety of methods like implant surgery and salvage procedures as partial or total ulnar head resection and the Sauve-Kapandji procedure are reasonable options in the elderly patient but not in young individuals since it often compromises manual power and stability and may cause impingement problems. Reconstruction of the DRUJ with rib perichondrium is a new treatment option with promising short-term outcome. The aim the present study was to investigate if the outcome is consistent over time.MethodsFour female patients with a mean age of 40.5 years suffered severe unilateral osteoarthritis in the DRUJ. They underwent reconstruction of the joint with rib perichondrium transplants. Preoperatively, mean pain under manual load was 8.5 (range 7-10) and 4.2 (range 2-5) at rest, using the visual analogue scale (VAS). Range of motion (ROM) in forearm rotation was on average 118° and grip strength was 86% in comparison to the contralateral hand. The outcome was assessed at a clinical follow-up in 2016, measuring ROM, grip-strength, pain at rest and under manual load and DASH-score. Radiological examination was performed. An additional follow-up by letter was performed in 2021 using a patient-reported-outcome survey (PROS). The patients were asked to grade the ROM and grip-strength as changed or unchanged in comparison to the clinical follow-up in 2016. ResultsAt clinical follow-up at a mean of 3.1 years (range 1-5) after surgery, pain level had decreased to VAS 1.5 (0-5) under load and all patients were pain free at rest. Forearm rotation was on average 156° (range 100-180) and grip strength was 97% of the unoperated hand. The mean DASH-score was 14.4 (0-45). An additional follow-up by letter was conducted at a mean of 7.5 years (5.5-9.5) after surgery. ROM and grip strength were reported as unchanged by all patients in relation to the previous clinical follow-up. No additional surgery or complications were reported. ConclusionReconstruction of the osteoarthritic DRU-joint with rib perichondrium transplantation can provide good clinical outcome with perseverance over time.Level of evidence: IV