bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial and ethnic disparities in emergency department restraint use: A multicenter retrospective analysis
Authors: Carreras Tartak Jossie A. , Brisbon Nicholas , Wilkie Sarah , Sequist Thomas D. , Aisiku Imoigele P. , Raja Ali , Macias‐Konstantopoulos Wendy L. 
Published: September 2021

AbstractBackgroundResearch regarding disparities in physical restraint use in the emergency department (ED) is limited. We evaluated the role of race, ethnicity, and preferred language on the application of physical restraint among ED patients held under a Massachusetts section 12(a) order for mandatory psychiatric evaluation.MethodsWe identified all ED patient encounters with a section 12(a) order across a large integrated 11‐hospital health system from January 2018 through December 2019. Information on age, race, ethnicity, preferred language, insurance, mental illness, substance use, history of homelessness, and in‐network primary care provider was obtained from the electronic health record. We evaluated for differences in physical restraint use between subgroups via a mixed‐effect logistic regression with random‐intercept model.ResultsWe identified 32,054 encounters involving a section 12(a) order. Physical restraints were used in 2,458 (7.7%) encounters. Factors associated with physical restraint included male sex (adjusted odds ratio [aOR] = 1.44, 95% confidence interval [CI] = 1.28 to 1.63), Black/African American race (aOR = 1.22, 95% CI = 1.01 to 1.48), Hispanic ethnicity (aOR = 1.45, 95% CI = 1.22 to 1.73), Medicaid insurance (aOR = 1.21, 95% CI = 1.05 to 1.39), and a diagnosis of bipolar disorder or psychotic disorder (aOR = 1.51, 95% CI = 1.31 to 1.74). Across all age groups, patients who were 25 to 34 years of age were at highest risk of restraint (aOR = 2.01, 95% CI = 1.69 to 2.39). Patients with a primary care provider within our network (aOR = 0.81, 95% CI = 0.72 to 0.92) were at lower risk of restraint. No associations were found between restraint use and language, history of alcohol or substance use, or homelessness.ConclusionBlack/African American and Hispanic patients under an involuntary mandatory emergency psychiatric evaluation hold order experience higher rates of physical restraint in the ED. Factors contributing to racial disparities in the use of physical restraint, including the potential role of structural racism and other forms of bias, merits further investigation.
A Smoke Evacuator Equipped With a Filter Contributes Enough to Safe Gas Exhaustion From the Abdominal Cavity
Authors: Hirota Masashi , Takahashi Hidekazu , Takahashi Tsuyoshi , Kurokawa Yukinori , Yamasaki Makoto , Eguchi Hidetoshi , Doki Yuichiro , Nakajima Kiyokazu 
Published: September 2021

AbstractSurgical plume (SP) carries biological risks such as virus transmission. An evacuation system can remove SP from the surgical field, but is it safe to release evacuated gas into the operating room (OR) atmosphere? We examined this using a commercially available evacuator equipped with a filter under a laparoscopic porcine surgery model. SP was generated by activating an electrocautery or ultrasonic scalpel on the surface of the liver, and we evaluated whether DNA fragments derived from porcine tissue were present in the exhausted gas from the evacuation system into the atmosphere. DNA fragments were detected in the inlet gas of the evacuation system, while it was not detected in the outlet gas. As far as pathogen transmission via SP in the abdominal cavity is concerned, if the smoke evacuator ensures filter adsorption, it seems that there is little risk in releasing the suction gas into the atmosphere in the OR.
Does reproductive effort influence the metabolic rate of Tomodon dorsatus snakes?
Authors: Lima‐Santos Jade , Almeida‐Santos Selma Maria , de Carvalho José Eduardo , Brasileiro Cinthia A. 
Published: September 2021

AbstractIn Squamate reptiles, vitellogenesis in females is marked by an increase in the number and size of follicles, leading to an increase in aerobic metabolism to support the rising energy demand during reproductive activity. Male gametes are smaller than female gametes, and spermiogenesis requires less energy than vitellogenesis. This investigation compares the relationship between aerobic metabolism and reproductive effort in male and female viviparous Tomodon dorsatus snakes. We evaluated the influence of the males' and females' reproductive stages, along with the masses of follicles and testicles, on their aerobic metabolic rate. Our findings show that females have higher maintenance cost of pregnancy than metabolic costs of vitellogenesis. In males, we found no evidence of the reproductive effort influencing aerobic metabolic rates. In T. dorsatus, females have a long period of development and high fecundity. Therefore, the metabolic costs of vitellogenesis represent a critical component in the reproductive effort. On the other hand, males of T. dorsatus maintain a similar mass of gonads throughout the year with constant energy demand. These results reflect the difference in reproductive efforts between females and males of T. dorsatus.
Vaginal birth after cesarean in women with no prior vaginal delivery carrying a large for gestational age baby
Authors: Levin Gabriel , Rosenbloom Joshua I. , Shai Daniel , Yagel Simcha , Yinon Yoav , Meyer Raanan 
Published: September 2021

AbstractBackgroundTo study the factors associated with successful labor after cesarean (LAC) among women with no prior vaginal delivery, delivering a large for gestational age (LGA) baby.MethodsA retrospective case‐control study at two tertiary medical centers in Israel, including all women undergoing LAC with no prior vaginal delivery during 2010‐2020, delivering a singleton LGA newborn. Factors associated with successful vaginal delivery were examined by a multivariable analysis.ResultsOverall, 323/505 (64.0%) had a successful LAC. Arrest of labor as the indication for previous CD was less common in the LAC success group [39 (12.1%) vs. 58 (31.9%), P < .001]. The rate of epidural analgesia was higher in the LAC success group [249 (77.1%) vs. 122 (67.0%), P = .014]. The rate of weight centile ≥97th was lower in the LAC success group [64 (19.8%) vs. 51 (28.0%), P = .035], as well as the rate of higher LAC birthweight than previous cesarean birthweight [264 (81.7%) vs. 162 (89.0%), P = .030].In a multivariable logistic regression analysis, maternal height (aOR [95% CI]:1.09 (1.01, 1.17), P = .014) and epidural anesthesia (aOR [95% CI]:3.68 (1.31, 10.32), P = .013) were the only independent factors associated with LAC success.ConclusionsAmong primiparous women undergoing LAC carrying LGA newborns, the vaginal delivery rate is acceptable; however, uterine rupture risk is increased. Epidural administration is a modifiable factor and should be taken into consideration during LAC management.
Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia
Authors: Saito Yusuke , Kinoshita Mariko , Yamada Ai , Kawano Sayaka , Liu Hong‐Shan , Kamimura Sachiyo , Nakagawa Midori , Nagasawa Syun , Taguchi Tadao , Yamada Shuhei , Moritake Hiroshi 
Published: September 2021

AbstractDiverse metabolic changes are induced by various driver oncogenes during the onset and progression of leukemia. By upregulating glycolysis, cancer cells acquire a proliferative advantage over normal hematopoietic cells; in addition, these changes in energy metabolism contribute to anticancer drug resistance. Because leukemia cells proliferate by consuming glucose as an energy source, an alternative nutrient source is essential when glucose levels in bone marrow are insufficient. We profiled sugar metabolism in leukemia cells and found that mannose is an energy source for glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Leukemia cells express high levels of phosphomannose isomerase (PMI), which mobilizes mannose to glycolysis; consequently, even mannose in the blood can be used as an energy source for glycolysis. Conversely, suppression of PMI expression or a mannose load exceeding the processing capacity of PMI inhibited transcription of genes related to mitochondrial metabolism and the TCA cycle, therefore suppressing the growth of leukemia cells. High PMI expression was also a poor prognostic factor for acute myeloid leukemia. Our findings reveal a new mechanism for glucose starvation resistance in leukemia. Furthermore, the combination of PMI suppression and mannose loading has potential as a novel treatment for driver oncogene‐independent leukemia.
Gut‐liver axis‐mediated mechanism of liver cancer: A special focus on the role of gut microbiota
Authors: Ohtani Naoko , Hara Eiji 
Published: September 2021

AbstractGut microbiota and the mammalian host share a symbiotic relationship, in which the host provides a suitable ecosystem for the gut bacteria to digest indigestible nutrients and produce useful metabolites. Although gut microbiota primarily reside in and influence the intestine, they also regulate liver function via absorption and subsequent transfer of microbial components and metabolites through the portal vein to the liver. Due to this transfer, the liver may be continuously exposed to gut‐derived metabolites and components. For example, short‐chain fatty acids (SCFA) produced by gut microbiota, through the fermentation of dietary fiber, can suppress inflammation via regulatory T cell induction through SCFA‐induced epigenetic mechanisms. Additionally, secondary bile acids (BA), such as deoxycholic acid, produced by gut bacteria through the 7α‐dehydroxylation of primary BAs, are thought to induce DNA damage and contribute to the remodeling of tumor microenvironments. Other substances that are also thought to influence liver function include lipopolysaccharides (components of the outer membrane of gram‐negative bacteria) and lipoteichoic acid (cell wall component of Gram‐positive bacteria), which are ligands of innate immune receptors, Toll‐like receptor‐4, and Toll‐like receptor‐2, respectively, through which inflammatory signaling is elicited. In this review, we focus on the role of gut microbiota in the liver microenvironment, describing the anatomy of the gut‐liver axis, the role of gut microbial metabolites, and the relationships that exist between gut microbiota and liver diseases, including liver cancer.
Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer
Authors: Nagase Hiroki , Watanabe Takayoshi , Koshikawa Nobuko , Yamamoto Seigi , Takenaga Keizo , Lin Jason 
Published: September 2021

AbstractAs the energy factory for the cell, the mitochondrion, through its role of adenosine triphosphate production by oxidative phosphorylation, can be regarded as the guardian of well regulated cellular metabolism; the integrity of mitochondrial functions, however, is particularly vulnerable in cancer due to the lack of superstructures such as histone and lamina folds to protect the mitochondrial genome from unintended exposure, which consequently elevates risks of mutation. In cancer, mechanisms responsible for enforcing quality control surveillance for identifying and eliminating defective mitochondria are often poorly regulated, and certain uneliminated mitochondrial DNA (mtDNA) mutations and polymorphisms can be advantageous for the proliferation, progression, and metastasis of tumor cells. Such pathogenic mtDNA aberrations are likely to increase and occasionally be homoplasmic in cancer cells and, intriguingly, in normal cells in the proximity of tumor microenvironments as well. Distinct characteristics of these abnormalities in mtDNA may provide a new path for cancer therapy. Here we discuss a promising novel therapeutic strategy, using the sequence‐specific properties of pyrrole‐imidazole polyamide‐triphenylphosphonium conjugates, against cancer for clearing abnormal mtDNA by reactivating mitochondrial quality control surveillance.
Gamification and family leisure to alleviate the psychological impact of confinement due to COVID‐19
Authors: Manzano‐León Ana , Rodríguez‐Ferrer José Miguel , Aguilar‐Parra José Manuel , Herranz‐Hernández Rafael 
Published: September 2021

AbstractThis study presents a quasi‐experimental longitudinal mixed‐methods research about the participation in leisure activities, physical activity, and games, as part of the family leisure programme (“Lunae Magic School”) for Spanish families with children under 12 years old during COVID‐19 lockdown. The impact on parents and their perception of the psychological well‐being of their children is evaluated. The results show that leisure activities reduce the parent's anxiety levels measured with STAI scale (p = .0001) and their perception of the physical and emotional discomfort of their children, measured with PSC scale (p < .0001). It is qualitatively argued that despite the confinement situation, the gamification, the variety of activities and the fact of being able to enjoy quality time with the family have allowed the creation of spaces of fun and flow. Therefore, although the findings on the importance of family leisure were encouraging, more research is needed on the implementation of similar programmes.
Mechanistic invasive species management models and their application in conservation
Authors: Thompson Brielle K. , Olden Julian D. , Converse Sarah J. 
Published: September 2021

AbstractManagement strategies to address the challenges associated with invasive species are critical for effective conservation. An increasing variety of mathematical models offer insight into invasive populations, and can help managers identify cost effective prevention, control, and eradication actions. Despite this, as model complexity grows, so does the inaccessibility of these tools to conservation practitioners making decisions about management. Here, we seek to narrow the science‐practice gap by reviewing invasive species management models (ISMMs). We define ISMMs as mechanistic models used to explore invasive species management strategies, and include reaction‐advection–diffusion models, integrodifference equations, gravity models, particle transport models, nonspatial and spatial discrete‐time population growth models, cellular automata, and individual‐based models. For each approach, we describe the model framework and its implementation, discuss strengths and weaknesses, and give examples of conservation applications. We conclude by discussing how ISMMs can be used in concert with adaptive management to address scientific uncertainties impeding action and with multiple objective decision processes to evaluate tradeoffs among management objectives. We undertook this review to support more effective decision‐making involving invasive species by providing conservation practitioners with the information they need to identify tools most useful for their applications.
Validation of the Gait Outcomes Assessment List questionnaire and caregiver priorities for individuals with cerebral palsy
Authors: Boyer Elizabeth R , Palmer Madeline , Walt Kathryn , Georgiadis Andrew G , Stout Jean L 
Published: September 2021

AimTo expand upon previous validation of the Gait Outcomes Assessment List (GOAL) questionnaire in individuals with cerebral palsy (CP), to rank items by importance, and to summarize written‐in (free text) goals.MethodFor this cross‐sectional study, the parent‐version 5.0 of the GOAL was completed by 310 consecutive caregivers of 310 individuals aged 3 to 25 years with CP (189 males, 121 females; mean [SD] age: 10y [4y 2mo]; Gross Motor Function Classification System [GMFCS] levels I–IV) concurrent with a gait analysis. Distribution properties and validity were quantified using questionnaires, kinematics, and oxygen consumption. Items classified as at least ‘difficult’ to perform and ‘very important’ to improve were considered caregiver priorities and rank ordered. Free text goals were categorized. Results were summarized for everyone and by GMFCS level.ResultsMost scores were normally distributed. Validity was acceptable, with concurrent greater than construct validity. Among all 310 caregivers, fatigue was the highest priority, followed by gait pattern and appearance items. The rank of priorities varied by GMFCS level. Common free text goals included toileting independently as well as improved fine motor and ball sport skills.InterpretationThe GOAL is a valid tool that can help prioritize goals across GMFCS levels I to IV. Identifying the top goals may improve shared decision‐making and prioritize research for this sample.
The ongoing evolution of basal insulin therapy over 100 years and its promise for the future
Authors: Retnakaran Ravi , Zinman Bernard 
Published: September 2021

AbstractThe evolution of basal insulin therapy over the past 100 years since the discovery of insulin is a testimony to the biomedical bench‐to‐bedside process, wherein incremental advances in the basic sciences are progressively translated over time into a series of enhancements in clinical care, each building upon the success of its predecessors. The emergence of recombinant DNA technology and the resultant biosynthesis of human insulin in the 1980s provided the critical capacity to bioengineer designer insulin analogues with pharmacokinetic and pharmacodynamic properties that can better mimic, although not fully replicate, the effects of endogenous insulin secretion. Through these efforts, basal insulin therapy has progressed over this time from first‐generation analogues (glargine U‐100, detemir) to second‐generation analogues (glargine U‐300, degludec) to ultra‐long‐acting formulations that are suitable for administration once weekly (icodec). Each iteration in this progression has represented a step closer towards the goal of replicating the continuous secretion of insulin that normally comprises the basal output of the pancreatic beta‐cells between meals, during episodes of fasting and overnight. However, it may be that we may have reached the achievable limit in the context of an “open‐loop” approach, such that only with the addition of closed loop control will we be able to achieve physiologic basal insulin replacement. In this review, we will examine the evolution of basal insulin therapy over the past 100 years and its implications for patient care and outcomes in current practice and the future.
Pityriasis rosea‐like cutaneous eruption as a possible dermatological manifestation after Oxford‐AstraZeneca vaccine: Case report and brief literature review
Authors: Pedrazini Maria Cristina , da Silva Mariliza Henrique 
Published: September 2021

AbstractPityriasis rosea (PR) has been manifested in patients suffering from COVID‐19 as well as after vaccine protocols against SARS‐CoV‐2. It has a possible association with the HHV‐6B virus (roseola infantum) and can be controlled by antivirals such as acyclovir as well as by the amino acid l‐Lysine that showed a positive result in reducing the number of lesions and healing time. The aim of this study was to report a case of PR after a second dose of Oxford‐AstraZeneca, the adopted therapy and a brief literature review. A 53‐year‐old woman, phototype II, presented an erythematous lesion in the posterior right thigh 15 days after the second dose of Oxford‐AstraZeneca vaccine. Eight days after the initial injury, new injuries appeared in the calf, buttocks and thighs. The diagnosis was PR with a 5‐week eruption cycle. The treatment consisted of the use of l‐Lysine, 3 grams loading dose and 500 mg for 30 days and moisturizing/healing lotion, starting 14 days after the herald patch. After the 5th week of the disease cycle, there were no new eruptions and the repair cycle continued for up to 8 weeks leaving some residual skin spots. It is concluded that the patient may be a carrier a latent virus, HHV‐6, and the vaccine administration with immune system stimulation, would have activated the possible virus causing PR. l‐Lysine helped to control the manifestation by limiting the number of lesions and their location, which were restricted to the legs, thighs and buttocks.
Discounting and the market valuation of defined benefit pensions
Authors: Breedon Francis , Larcher Luca 
Published: September 2021

AbstractWe investigate how defined benefit pension (DB) schemes of the Financial Times Stock Exchange (FTSE) firms are valued by the equity market, focusing on how future liabilities are discounted (because UK data allows us to estimate the duration of pension liabilities fairly accurately). Our primary sample of FTSE 100 constituents includes mostly large DB sponsors with mature schemes, primarily closed to new entrants but still active for current employees. We find that equity market valuation of pension liabilities is consistent with discounting without allowing for credit risk, thus incorporating a valuation closer to their settlement value. This differs from the approach used in published accounts for which IAS 19 (and SFAS no. 158, its US equivalent) allows for discounting with a corporate bond yield. The difference is significant, as credit‐risk‐free discounting would decrease the reported value of FTSE 100 firms by about 7%.
A novel geographical research agenda on Silk Road urbanisation
Authors: Apostolopoulou Elia 
Published: September 2021

AbstractThe New Silk Road, also called China's Belt and Road Initiative (BRI), is the largest single infrastructure project since the Marshall Plan and an exemplar of infrastructure‐led development of a scope and scale with no precedent in modern history. The project is estimated to cost up to US$8 trillion, involve 130 countries and impact more than 65% of the world's population. Through novel combinations of infrastructure and industrial projects with investments in the urban built environment, the BRI is transforming urban space across the global South and North altering the social and urban geographies of cities at a historically unparalleled scale. Nonetheless, its role in driving global urban transformation remains fundamentally underexplored. Relevant geographical research is scarce and comparative approaches focusing on cities are in their infancy, leading researchers to talk about an ‘anti‐urban’ bias in contemporary BRI scholarship that prevents an in‐depth understanding of the initiative's true scope. This paper introduces the novel concept of Silk Road urbanisation and puts forward the need for a new research agenda that has the potential to transform geographical and urban research on infrastructure‐led development, urban transformation and inequality.
A survey of medical researchers indicates poor awareness of research data management processes and a role for data librarians
Authors: Milewska Agnieszka , Wiśniewska Natalia , Cimoszko Paulina , Rusakow Jakub 
Published: September 2021

AbstractBackgroundThe European Parliament's directive on open data indicates the direction to follow for all public institutions in Europe. The portal Polish Platform of Medical Research (PPM) required more information about researcher attitudes and training requirements for strategic planning.ObjectivesThe aim was to assess (1) the status of knowledge about research data management among medical researchers in Poland, and (2) their attitudes towards data sharing. This knowledge may help to inform a training program and adapt PPM to the requirements of researchers.MethodsThe authors circulated an online survey and received responses from 603 researchers representing medical sciences and related disciplines. The survey was conducted in 2019 at seven Polish medical universities and at the Nofer Institute of Occupational Medicine. Analysis used descriptive statistics.ResultsData sharing was not widespread (55.7% only shared with their research team, 9.8% had shared data on an open access basis). Many cited possible benefits of research data sharing but were concerned about drawbacks (e.g. fraud, plagiarism).DiscussionPolish medical scientists, like many researchers, are not aware of the processes required for safe data preparation for sharing. Academic libraries should develop roles for data librarians to help train researchers.ConclusionFears about the dangers of data sharing need to be overcome before researchers are willing to share their own research data.