bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of dental antibiotic prescribing in 2017: Australia, England, United States, and British Columbia (Canada)
Authors: Thompson Wendy , Teoh Leanne , Hubbard Colin C. , Marra Fawziah , Patrick David M. , Mamun Abdullah , Campbell Allen , Suda Katie J. 
Published: April 2021

AbstractObjective:Our objective was to compare patterns of dental antibiotic prescribing in Australia, England, and North America (United States and British Columbia, Canada).Design:Population-level analysis of antibiotic prescription.Setting:Outpatient prescribing by dentists in 2017.Participants:Patients receiving an antibiotic dispensed by an outpatient pharmacy.Methods:Prescription-based rates adjusted by population were compared overall and by antibiotic class. Contingency tables assessed differences in the proportion of antibiotic class by country.Results:In 2017, dentists in the United States had the highest antibiotic prescribing rate per 1,000 population and Australia had the lowest rate. The penicillin class, particularly amoxicillin, was the most frequently prescribed for all countries. The second most common agents prescribed were clindamycin in the United States and British Columbia (Canada) and metronidazole in Australia and England. Broad-spectrum agents, amoxicillin-clavulanic acid, and azithromycin were the highest in Australia and the United States, respectively.Conclusion:Extreme differences exist in antibiotics prescribed by dentists in Australia, England, the United States, and British Columbia. The United States had twice the antibiotic prescription rate of Australia and the most frequently prescribed antibiotic in the US was clindamycin. Significant opportunities exist for the global dental community to update their prescribing behavior relating to second-line agents for penicillin allergic patients and to contribute to international efforts addressing antibiotic resistance. Patient safety improvements will result from optimizing dental antibiotic prescribing, especially for antibiotics associated with resistance (broad-spectrum agents) or C. difficile (clindamycin). Dental antibiotic stewardship programs are urgently needed worldwide.
A longitudinal evaluation of the impact of the COVID-19 pandemic on patients with pre-existing anxiety disorders
Authors: Hennigan K. , McGovern M. , Plunkett R. , Costello S. , McDonald C. , Hallahan B. 
Published: April 2021

AbstractObjectives:To examine if the COVID-19 pandemic is associated with a differential effect over time in relation to its psychological and social impact on patients with established anxiety disorders.Methods:Semi-structured interviews were conducted with 24 individuals attending the Galway–Roscommon Mental Health Services with an International Classification of Diseases (ICD)-10 diagnosis of an anxiety disorder at two time points (six months apart) to determine the impact of the COVID-19 restrictions on anxiety and depressive symptoms, social and occupational functioning and quality of life.Results:No statistical difference in symptomatology was noted between the two time points in relation to anxiety symptoms as measured by utilising psychometric rating scales (BAI and HARS) or utilising a Likert scale. The greatest impact of COVID-19 at both time points is related to social functioning and quality of life. Significant variability was noted for individual participants. Qualitative analysis noted social isolation, concern for the participants’ future and increased difficulty managing anxiety with ongoing restrictions.Conclusions:No significant overall change in symptomatology or functioning over time was noted for individuals with pre-existing anxiety disorders. Variability was, however, demonstrated between individuals, with some individuals describing ongoing anxiety, social isolation and concern for their future. Identifying those with ongoing symptoms or distress and providing multidisciplinary support to this cohort is suggested.
A theory of children's decisional privacy
Authors: Dimopoulos Georgina 
Published: April 2021

AbstractDecisional privacy offers individuals the freedom to act and to make important decisions about how they live their lives, without unjustifiable interference from other individuals or the state. Children's perceived vulnerability, incapacity for rational decision-making and dependence on adults have been used to justify depriving children of decisional privacy rights and subjecting them to the exercise of adult power over the conditions of their lives. The aim of this paper is to articulate a theory of children's decisional privacy. It is argued that decisional privacy is valued as a condition that enables individual autonomy. A relational, gradual conception of autonomy is advanced, to explain how children can be recognised as having the capacity for autonomy, and in some circumstances, actual autonomy. This paper presents four fundamental principles of a children's rights approach to decisional privacy, which collectively serve to enhance children's meaningful participation in decision-making about their best interests, consistently with children's evolving capacities and the receipt of appropriate parental direction and guidance. The theory developed in this paper presents an opportunity for adult decision-makers to reflect upon how they make decisions for and about children, and how children can play a meaningful role in those decision-making processes.
The men’s mental health perspective on adolescent suicide in the COVID-19 era
Authors: Rice Timothy , Sher Leo 
Published: April 2021

Abstract

Objective:
The COVID-19 pandemic has drastically changed society and introduced many new factors to consider in adolescent suicide risk assessment and prevention. One complexity that warrants consideration is the male-specific impacts of the pandemic within adolescence.

Methods:
A review of the relevant literature.

Results:
Matters of social distancing, virtual education, and substance use may impact adolescent men in fashions that raise their suicide risk more significantly relative to adolescent women. Social distancing may impact adolescents’ friendships and generate a regression back to the nuclear family; qualities of male adolescents’ friendships and of masculinity suggest that these impacts may be more severe in adolescent men and may directly raise suicide risk. Virtual schooling yields educational and social setbacks; losses of team sports, male mentors, and the implications of diminished educational advancement may more adversely affect adolescent men and raise risk. Substance use has increased in the pandemic, particularly amongst adolescent men. There are direct associations with suicide risk as well as indirectly through increased parental conflict and punishment.

Conclusion:
As adolescent men die by suicide at significantly elevated rates relative to adolescent women, a male-specific consideration of these impacts is indicated to address adolescent suicide in our current era. Recommendations are made for integrating these considerations into updated adolescent suicide risk assessment and prevention efforts.
Facies characterisation of sediments from the East Frisian Wadden Sea (Germany): new insights from down-core scanning techniques
Authors: Lee An-Sheng , Enters Dirk , Titschack Jürgen , Zolitschka Bernd 
Published: April 2021

AbstractSediment facies provide fundamental information to interpret palaeoenvironments, climatic variation, archaeological aspects and natural resource potentials since they are summary products of depositional processes, environmental conditions and biological activities for a given time and location. The conventional method of facies discrimination relies on macroscopic and/or microscopic determination of sediment structures combined with basic physical, chemical and biological information. It is a qualitative measure, depending on observer-dependent sedimentological descriptions, which cannot be reanalysed readily by further studies. Quantitative laboratory measurements can overcome this disadvantage, but are in need of large sample numbers and/or high temporal resolution, and are time-, labour- and cost-intensive. In order to facilitate an observer-independent and efficient method of facies classification, our study evaluates the potential of combining four non-destructive down-core scanning techniques: magnetic susceptibility (MS), X-ray computed tomography (CT), X-ray fluorescence (XRF) and digital photography. These techniques were applied on selected sections of sediment cores recovered around the island of Norderney (East Frisian Wadden Sea, Germany). We process and integrate the acquired scanning measurements of XRF elemental intensities, represented by principal components, MS, CT density and lightness of eight sediment facies previously recognised by conventional facies analysis: moraine, eolian/fluvial, soil, peat, lagoonal, sand flat, channel fill and beach-foreshore. A novel type of density plot is introduced to visualise the digitised sediment information that allows an observer-independent differentiation of these facies types. Thus, the presented methodology provides the first step towards automated supervised facies classification with the potential to reproduce human assessments in a fully reproducible and quantitative manner.
n-3 long-chain PUFA promote antibacterial and inflammation-resolving effects inMycobacterium tuberculosis-infected C3HeB/FeJ mice, dependent on fatty acid status
Authors: Nienaber Arista , Ozturk Mumin , Dolman Robin , Blaauw Renee , Zandberg Lizelle L. , van Rensburg Simone , Britz Melinda , Hayford Frank E. A. , Brombacher Frank , Loots Du Toit , Smuts Cornelius M. , Parihar Suraj P. , Malan Linda 
Published: April 2021

AbstractNon-resolving inflammation is characteristic of tuberculosis (TB). Given their inflammation-resolving properties,n-3 long-chain PUFA (n-3 LCPUFA) may support TB treatment. This research aimed to investigate the effects ofn-3 LCPUFA on clinical and inflammatory outcomes ofMycobacterium tuberculosis-infected C3HeB/FeJ mice with either normal or lown-3 PUFA status before infection. Using a two-by-two design, uninfected mice were conditioned on either ann-3 PUFA-sufficient (n-3FAS) or -deficient (n-3FAD) diet for 6 weeks. One week post-infection, mice were randomised to eithern-3 LCPUFA supplemented (n-3FAS/n-3+ andn-3FAD/n-3+) or continued onn-3FAS orn-3FAD diets for 3 weeks. Mice were euthanised and fatty acid status, lung bacterial load and pathology, cytokine, lipid mediator and immune cell phenotype analysed.n-3 LCPUFA supplementation inn-3FAS mice lowered lung bacterial loads (P= 0·003), T cells (P= 0·019), CD4+T cells (P= 0·014) and interferon (IFN)-γ(P< 0·001) and promoted a pro-resolving lung lipid mediator profile. Compared withn-3FAS mice, then-3FAD group had lower bacterial loads (P= 0·037), significantly higher immune cell recruitment and a more pro-inflammatory lipid mediator profile, however, significantly lower lung IFN-γ, IL-1α, IL-1βand IL-17, and supplementation in then-3FAD group provided no beneficial effect on lung bacterial load or inflammation. Our study provides the first evidence thatn-3 LCPUFA supplementation has antibacterial and inflammation-resolving benefits in TB when provided 1 week after infection in the context of a sufficientn-3 PUFA status, whilst a lown-3 PUFA status may promote better bacterial control and lower lung inflammation not benefiting fromn-3 LCPUFA supplementation.
Impact of maternal obesity and prebiotic supplementation on select maternal milk microRNA levels and correlation with offspring outcomes
Authors: Lowry Dana E. , Paul Heather A. , Reimer Raylene A. 
Published: April 2021

AbstractBreast milk composition varies with maternal factors including diet and confers health benefits to the neonate; however, the mechanisms mediating this protection remain incompletely understood. Our aim was to investigate the effects of supplementing a maternal high-fat/sucrose (HFS) diet with prebiotic oligofructose (OFS) on milk composition in rats and associations with offspring body composition and gut microbiota. Obese Sprague–Dawley dams consumed a control, HFS, HFS + OFS (10 % wt/wt) or HFS diet weight-matched to the HFS + OFS group (HFS-WM) during pregnancy and lactation. Pups were weaned onto a HFS diet on day 21. Milk was collected at weaning and analysed for protein, leptin and microRNA (miRNA) levels. Milk produced by HFS dams contained less protein than milk from lean controls which was normalised by OFS. Six miRNA (miR-222, miR-203a, miR-200a, miR-26a, miR-27a and miR-103) were differentially expressed in milk according to maternal diet. Milk leptin content was positively correlated with maternal body fat and faecal Enterobacteriaceae in male offspring at 24 weeks of age. Milk protein content was inversely associated with maternal body fat and body weight. miR-200a was positively associated with maternal body fat and Enterobacteriaceae in female offspring at 24 weeks of age. Correlations between milk protein and multiple milk miRNA and offspring body composition and gut microbiota differed by sex. Overall, our results suggest that obesogenic diets and prebiotic supplementation can alter the protein and miRNA levels in breast milk in rats and these milk components may explain, in part, the influence of these maternal diets on offspring body composition.
Selection of models to describe the temperature-dependent development of Neoleucinodes elegantalis (Lepidoptera: Crambidae) and its application to predict the species voltinism under future climate conditions
Authors: Santos Hevellyn Talissa dos , Marchioro Cesar Augusto 
Published: April 2021

AbstractThe small tomato borer, Neoleucinodes elegantalis (Guenée, 1854) is a multivoltine pest of tomato and other cultivated solanaceous plants. The knowledge on how N. elegantalis respond to temperature may help in the development of pest management strategies, and in the understanding of the effects of climate change on its voltinism. In this context, this study aimed to select models to describe the temperature-dependent development rate of N. elegantalis and apply the best models to evaluate the impacts of climate change on pest voltinism. Voltinism was estimated with the best fit non-linear model and the degree-day approach using future climate change scenarios representing intermediary and high greenhouse gas emission rates. Two out of the six models assessed showed a good fit to the observed data and accurately estimated the thermal thresholds of N. elegantalis. The degree-day and the non-linear model estimated more generations in the warmer regions and fewer generations in the colder areas, but differences of up to 41% between models were recorded mainly in the warmer regions. In general, both models predicted an increase in the voltinism of N. elegantalis in most of the study area, and this increase was more pronounced in the scenarios with high emission of greenhouse gases. The mathematical model (74.8%) and the location (9.8%) were the factors that mostly contributed to the observed variation in pest voltinism. Our findings highlight the impact of climate change on the voltinism of N. elegantalis and indicate that an increase in its population growth is expected in most regions of the study area.
CanAnastrepha fraterculuslarval feeding influence chemotaxis and parasitism ofDiachasmimorpha longicaudataandAganaspis pelleranoi?
Authors: Pires Patricia Daniela da Silva , Sant’ Ana Josué , Redaelli Luiza Rodrigues 
Published: April 2021

AbstractAnastrepha fraterculus(Diptera: Tephritidae) is a major barrier to fruit production and exportation. In Brazil, the native parasitoidAganaspis pelleranoi(Hymenoptera: Figitidae) and the exotic parasitoidDiachasmimorpha longicaudata(Hymenoptera, Braconidae) stand out as biological control agents. Knowledge of the factors that affect interactions among parasitoids,A. fraterculus, and host fruits may enhance the use of these agents in biological control programmes. This study evaluated the chemotaxis and parasitism ofA. pelleranoiandD. longicaudatafemales reared onA. fraterculuslarvae and kept on an artificial diet, red guava (Psidium guajava) or apple (Malus domestica). Females of both parasitoid species that emerged from larvae raised on artificial diet, guava or apple, were tested to Y olfactometer choice tests. In the parasitism tests, both parasitoid species were made to choose betweenA. fraterculuslarvae brushed with water, apple pulp or guava pulp.D. longicaudatafemales from artificial diet (control) did not distinguish between fruit odours; however, females ofD. longicaudatafrom larvae kept in apple or guava directed to the odours of their original fruit. The greatest parasitism forD. longicaudataoccurred in the units that contained the pulp in which the larvae grew.A. pelleranoifrom artificial diet preferred guava odours, including the females kept in apple. Similar results were observed in the parasitism bioassays. Our results found thatA. fraterculuslarval feeding influenced search behaviour and parasitism ofD. longicaudata, whereasA. pelleranoirearing experience did not affect its host choices.
Middle Jurassic arc reversal, Victoria–Katha Block and Sibumasu Terrane collision, jadeite formation and Western Tin Belt generation, Myanmar
Authors: Mitchell Andrew , Htay Myint Thein , Htun Kyaw Min 
Published: April 2021

AbstractMyanmar is occupied by the N-wards continuation of the Sunda arc and by the Shan Plateau and its continuation through Yunnan into Tibet. Our new tectonic interpretation of the ophiolite–flysch belts, world-famous jadeite and tin deposits in Myanmar west of the Salween adopts previous proposals that, before 450-km post-early Oligocene dextral displacement along the Sagaing Fault, the ophiolite belt in NE Myanmar continued through the topography that is now located west of the fault in the Indo-Burman Ranges. Differences in cross-section through Mogok and the Shan Scarps are reconciled by the recently proposed emplacement, in our view during Permian time, of the Mogok Metamorphic Group onto the Slate Belt to form Sibumasu. We argue that during Early Jurassic time a Neo-Tethys ophiolite nappe was obducted over turbidites on Sibumasu’s passive western margin. Following reversal in tectonic polarity, the remaining Neo-Tethys subducted E-wards generating the 113–128 Ma Mondaung Arc. During ocean closure the Victoria–Katha Block and its Triassic flysch subducted beneath Sibumasu, resulting in jadeite veins in overlying serpentinite that ascended in the subduction zone and were exhumed at Hpakant and Nat Hmaw, bordering the Jade Mines Uplift. Subduction of the Indian Ocean since Albian time generated the Popa–Loimye arc, while extensional faulting led to uplift of the Indo-Burman Ranges and to the formation of the Western Tin Belt granites. Tectonic effects in Myanmar of the India–Asia collision may be confined to the Disang thrust belt in the Naga Hills.
Robustness of Empirical Evidence for the Democratic Peace: A Nonparametric Sensitivity Analysis
Authors: Imai Kosuke , Lo James 
Published: April 2021

AbstractThe democratic peace—the idea that democracies rarely fight one another—has been called “the closest thing we have to an empirical law in the study of international relations.” Yet, some contend that this relationship is spurious and suggest alternative explanations. Unfortunately, in the absence of randomized experiments, we can never rule out the possible existence of such confounding biases. Rather than commonly used regression-based approaches, we apply a nonparametric sensitivity analysis. We show that overturning the negative association between democracy and conflict would require a confounder that is forty-seven times more prevalent in democratic dyads than in other dyads. To put this number in context, the relationship between democracy and peace is at least five times as robust as that between smoking and lung cancer. To explain away the democratic peace, therefore, scholars would have to find far more powerful confounders than those already identified in the literature.
Insights into attention-deficit/hyperactivity disorder from recent genetic studies
Authors: Brikell Isabell , Burton Christie , Mota Nina Roth , Martin Joanna 
Published: April 2021

AbstractAttention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder (NDD). In this narrative review, we summarize recent advances in quantitative and molecular genetic research from the past 5–10 years. Combined with large-scale international collaboration, these advances have resulted in fast-paced progress in understanding the etiology of ADHD and how genetic risk factors map on to clinical heterogeneity. Studies are converging on a number of key insights. First, ADHD is a highly polygenic NDD with a complex genetic architecture encompassing risk variants across the spectrum of allelic frequencies, which are implicated in neurobiological processes. Second, genetic studies strongly suggest that ADHD diagnosis shares a large proportion of genetic risks with continuously distributed traits of ADHD in the population, with shared genetic risks also seen across development and sex. Third, ADHD genetic risks are shared with those implicated in many other neurodevelopmental, psychiatric and somatic phenotypes. As sample sizes and the diversity of genetic studies continue to increase through international collaborative efforts, we anticipate further success with gene discovery, characterization of how the ADHD phenotype relates to other human traits and growing potential to use genomic risk factors for understanding clinical trajectories and for precision medicine approaches.
A New Austrian Regionalism: Alfons Walde and Austrian Identity in Painting after 1918
Authors: Secklehner Julia 
Published: April 2021

AbstractThis essay assesses the role of regionalism in interwar Austrian painting with a focus on the Tyrolean painter and architect Alfons Walde (1891–1958). At a time when painting was seen to be in crisis, eclipsed by the deaths of prominent Viennese artists such as Gustav Klimt and Egon Schiele, regionalism offered an alternative engagement with modern art. As the representative of a wider regionalist movement, Walde paved the way for a clearly identifiable image of rural Austria without foregoing the modernization process that took place in the Alps at the time. Filtering essential elements of local culture and synthesizing them with both a modern formal language and “modern” topics, most significantly ski tourism, he created a regionalism that reverberated beyond the narrow confines of his home province and caught particular momentum during the rise of the AustrianStändestaatin the 1930s. Moving in between regional and national significance, Walde's work underlines the essential position of the region in Austria after 1918 and conveys that an engaged regionalism that responded to the rapid cultural and political changes taking place became a significant aspect of interwar Austrian painting.