bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life among cardiovascular patients enrolled in adult cardiology clinic in a tertiary hospital
Authors: Pedreso EJ , Alamban L , Faderan B 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Determining the level of health-related quality of life among cardiovascular patients and looking into the demographic factors and clinical characteristics that might influence the dynamics of their physical and mental health are highly essential for health practitioners to improve current management procedures and interventions.

Objective
The study was conducted to evaluate the level of health-related quality of life among cardiac patients seen in adult cardiology clinic.

Methods
This study used a descriptive research design. A total of 117 cardiac patients at the adult Cardiology Clinic in a Tertiary Hospital were interviewed using the MOS-SF – 36 Questionnaire. Statistical correlation analysis was then performed.

Results
The results showed that the patients are challenged in their physical functioning and general mental health with an average score of 33.33 ± 33.33 aside from their average median score of 55 ± 0.0 in their role limitations due to physical health. In terms of mental health, higher score was reflected for vitality (75 ± 12.5), followed by emotional well-being (67.5 ± 20.0). Demographic and clinical factors that affect their quality of life were also determined. Marital status, family income, educational attainment and participation on cardiac rehabilitation program affect their quality of life. Married, income above Php10,000, college level, college graduate or with post graduate degree and those who participated in the cardiac rehabilitation program have higher level of physical health (W = 1127; p=.007; W = 1729.5; p=.024; W = 1300; p=.043). Consistently, those who are married, a family income of above Php10,000 and are aware on cardiac rehabilitation have higher level of mental health (W = 1189; p=.019; W = 1895; p=.001; W = 1187; p=.005). Although not statistically significant, an increase in age is associated with decrease in the physical health (r=-.176; p=.058). It should not also be discounted that those patients who are employed have higher level of physical health than those who were unemployed (W = 1729.5; p=.052). Moreover, health change are higher for those who participated in the cardiac rehabilitation program (W = 960; p=.003). On clinical characteristics, those who underwent interventions have higher level of health change than those who only received medical management (W = 100.0; p&lt;.001). Mental health was also seen to be higher in those patients with no history of smoking and with &gt;40% left ventricular ejection fraction (W = 264.5; p=.005).

Conclusion
This study concludes that those patients who are married, employed, with income above Php10,000, who have higher educational status, non-smoker, LVEF of more than 40%, who received interventions and who underwent cardiac rehabilitation have higher level of quality of life.
Control of cardiovascular risk factors in a vascular retinopathy population and its long-term impact
Authors: Aguila Gordo D , Marina Breysse M , Piqueras Flores J , Martinez Del Rio J , Mateo Gomez C , Salas Bravo D , Moron Alguacil A , Frias Garcia R , Munoz Garcia M , Perez Diaz P , Negreira Caamano M , Perez Soto M , Cubides Novoa AF 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Control of cardiovascular risk factors is the cornerstone of secondary prevention. However, in patients with retinopathy of vascular etiology (hypertensive, diabetic or atherosclerotic) the benefit of stricter control of lipid in the long term has been little studied.

Methods
Prospective study of a cohort of 107 patients who underwent fundus and coronary angiography, of which 42 (39.3%) required percutaneous revascularization. During the follow-up, new cardiovascular events and analytical control of cardiovascular risk factors were recorded.

Results
Mean age was 75.19 ± 11.53 years. 60.7% were men, 78.5% were hypertensive, 32.7% were diabetic, and dyslipidemia was observed in 57%. Initially, 28% had 1-vessel disease, 14% 2-vessel, 8.4% 3-vessel, and 3.8% left common trunk. 0.9% had diabetic retinopathy, 3.7% had hypertensive retinopathy, 1.9% atherosclerotic, 70.1% had a combination of hypertensive and atherosclerotic retinopathy, and 7.5% signs compatible with all types. Initial and final mean values of LDL-c and HDL-c by type of retinopathy are in Table 1. During follow-up, a significant improvement in LDL-c and HDL-c levels was observed in total patients and in patients with hypertensive and atherosclerotic retinopathy, however globally lipid control was poor and only 18.9% of the total of the sample reached the recommended levels for very high-risk people (&lt;55 LDL-C). Advanced hypertensive retinopathy patients with a greater reduction in LDL-C during follow-up, recorded lower mortality (p = 0.004). Besides, patients with previous percutaneous revascularization showed a greater decrease in LDL levels at the end of follow-up (69.5 ± 26.1 vs 103 ± 41.47; p &lt;0.001); without significant changes in the rest of parameters.

Conclusions
In patients with vascular etiology retinopathy, long-term lipid control is poor. However, patients with hypertensive retinopathy and a greater reduction in LDL-c had lower long-term mortality.
Hypertensive retinopathy Initial Final Sig. LDL-Cholesterol (mg / dl) 102,8+/-35,5 75,65+/-28,9 &lt;0,001 HDL-Cholesterol (mg / dl) 42,1+/-10,3 43,46+/-13,1 0,04 Atherosclerotic retinopathy LDL-Cholesterol (mg / dl) 101,2+/-36,8 79,8+/-32,98 &lt;0,001 HDL-Cholesterol (mg / dl) 42,8+/-11,6 45,73+/-13,9 0,03 Diabetic retinopathy LDL-Cholesterol (mg / dl) 89,1+/-35,8 69,8+/-18 0,73 HDL-Cholesterol (mg / dl) 35,2+/-8,7 31,51+/-12,7 0,73
Temporal changes in the implementation of secondary prevention of coronary artery disease in every day practice
Authors: Peksa JW , Jankowski P , Koziel P , Bogacki P , Gomula P , Mirek-Bryniarska E , Nessler J , Podolec P , Wisniewski AK , Rajzer M , Czarnecka D , Pajak A 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

OnBehalf
-

Introduction
Patients with coronary artery disease (CAD) are at high risk of recurrent cardiovascular events and control of their risk factors is crucial.

Objectives
Comparison of risk factors control in patients with CAD in 2016–2017 and 2011–2013.

Patients and methods
Five hospitals with cardiology departments serving the city and surrounding districts participated in the study. Consecutive patients hospitalized due to an acute coronary syndrome or a myocardial revascularization procedure were interviewed 6–18 months after hospitalization. The surveys were carried out in 2011–2013 and 2016–2017.

Results
We examined 616 patients in 2011–2013 and 388 in 2016–2017 (mean age: 64.7 ± 8.8 vs. 66.4 ± 8.4, P &lt;0.01). After adjusting for covariates the proportion of patients with high blood pressure decreased by 8.9% (95% confidence intervals: -2.1% – -15.6%) and proportion of patients with high LDL cholesterol decreased by 9.5% (-2.2% – -16.7%) in 2016/2017 compared to 2011/2013, whereas the proportion of smoking patients (-0.2% [-6.0% – 5.5%]) and those with high glucose level (3.9% [-2.2% - 10.0%]) and with body mass index ≥25 kg/m2 (3.8% [-3.9% – 11.6%]) did not change significantly. The proportion of patients prescribed antiplatelets (6.5% [2.6% - 10.3%]), β-blockers (7.4% [2.2% - 12.6%]), angiotensin converting enzyme inhibitors or sartans (8.6% [2.9% – 14.3%]), calcium antagonists (8.1% [1.3 – 15.0]) and anticoagulants (5.5% [0.7% - 10.2%]) increased significantly.

Conclusions
In CAD patients, there was an increase of the proportion of patients with cardiovascular drugs prescribed and a slight improvement in the control of blood pressure and LDL cholesterol between 2011–2013 and 2016–2017. However, no significant changes were found for the other main risk factors.
Patients who do not reach treatment goal Survey Smoking, % BP not at goal, %a BP ≥140/90 mmHg, % LDL cholesterol ≥1.8 mmol/l, % HbA1c ≥7.0%b, % Fasting glucose ≥7.0 mmol/l, % BMI≥25 kg/m2, % BMI≥30 kg/m2, % 2011-2013 19.0 50.3 43.0 71.9 14.1 15.9 81.2 33.8 2016-2017 16.2 40.7 39.2 60.3 14.9 20.2 83.4 38.3 P value 0.26 &lt;0.01 0.24 &lt;0.001 0.76 0.09 0.37 0.14 Differences adjusted for age, sex, index diagnosis, duration of education, professional activity (95% confidence intervals) 2016-2017 vs 2011-2013 -0.2(-6.0 - 5.5) -8.9(-15.6 - -2.1) -6.7(-14.3 - 1.0) -9.5(-16.7 - -2.2) 2.0(-3.4 - 7.4) 3.9(-2.2 - 10.0) 3.8(-3.9 - 11.6) 1.6 (-5.8 - 9.0) Abbreviations BMI, body mass index; BP, blood pressure; LDL, low-density lipoprotein a BP goal of &lt;140/90mmHg (&lt;130/80 mmHg in diabetics) in 2011–2013 and &lt;140/90 mmHg (&lt;140/85 mmHg in diabetics) in 2016–2017 b available for 362 patients in 2011-2013 and 383 patients in 2016-2017
The impact of lipid profile in acute coronary syndrome: young patient vs old patient
Authors: Correia J , Neto V , Santos J , Pires I , Goncalves L , Costa A , Cabral J 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Several studies have suggested a relationship between dyslipidemia and atherogenesis, which displays a main role in the pathophysiology of Acute Coronary Syndrome (ACS).

Aim
To compare the lipid profile between younger (&lt;55 years) and older (≥55 years) patients admitted due to ACS.

Methods
A single-centre retrospective study was conducted, with inclusion of all consecutive patients admitted in the Cardiology Department due to ACS. Several analytical parameters were evaluated, including total cholesterol (CT), HDL cholesterol (HDL), LDL cholesterol (LDL) and triglycerides (TG) and CT/HDL, LDL/HDL and TG/HDL ratios were calculated. All parameters are presented in mg/dL. Afterwards, comparison of these data between younger (age &lt; 55 years, Group-A) and older (age≥55 years, Group-B) patients was done. Statistical analysis was performed with SPSS and a p value &lt; 0.05 was considered statistically significant.

Results
1168 patients (70.1% male, mean age 69 ±12 years) were included in this study. 15.8% of patients were from Group-A. Mean levels of the analysed parameters were the following: CT 176 ± 55, LDL 111 ± 45, HDL 40 ± 12 and TG 137 ± 102. The following mean ratios were obtained: CT/HDL 4.6 ± 1.9, LDL/HDL 2.9 ± 1.4 and TG/HDL 3.8 ± 3.5. Comparison of the analysed parameters and calculated ratios is exhibited in table 1.

Conclusion
Overall, a worse lipid profile was observed in younger patients. This data reveals the role of dyslipidemia in coronary heart disease, which displays a main role in atherosclerosis at a younger age. This fact highlights the importance of adopting a healthy lifestyle and the adherence to primary and secondary prevention measures of cardiovascular events.
Lipid profile: young vs old patient Group A Group B Total Cholesterol 199 ± 44 170 ± 56 p &lt; 0.001 LDL Cholesterol 128 ± 37 107 ± 46 p &lt; 0.001 HDL Cholesterol 39 ± 10 40 ± 12 p = 0.307 Triglycerides 195 ± 189 125 ± 66 p &lt; 0.001 CT/HDL 5.3 ± 1.5 6.8 ± 2.0 p &lt; 0.001 LDL/HDL 3.4 ± 1.1 2.8 ± 1.4 p &lt; 0.001 TG/HDL 5.6 ± 6.3 3.5 ± 2.5 p &lt; 0.001
Association of altered lipid profile with disease activity, duration, and glucocorticoid treatment in patients with idiopathic inflammatory myopathies
Authors: Oreska S , Storkanova H , Spiritovic M , Hermankova B , Vrablik M , Pavelka K , Senolt L , Mann H , Vencovsky J , Tomcik M 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): AZV CR, Czech health research council MHCR, Ministry of Health Dzech republic

Background
Systemic inflammation, limited mobility, and glucocorticoid treatment in Idiopathic inflammatory myopathies (IIM) can have a negative impact on intermediate metabolic pathways, especially on lipid metabolism.

Purpose
The aim of this study was to assess the differences in the lipid profile of IIM patients and healthy controls (HC) and the association with disease-specific features.

Methods
133 patients with IIM (106 females; mean age 60.3; disease duration 2.2 years; dermatomyositis, DM 47 / polymyositis, PM 41 / immune-mediated necrotizing myopathy, IMNM 45) and 133 age-/sex-matched HC (106 females, mean age 60.2) were included. Data are presented as median (IQR).

Results
Several differences in disease activity, the dose of glucocorticoids, prevalence of comorbidities, and serum lipid levels were observed among the three subtypes of IIM. Lipid profile parameters, especially levels of negative cardiovascular predictive markers such as TC, TG, LDL-C, Apo-B, and the atherogenic index were significantly higher compared to HC. The most significant changes were observed in IMNM compared to age-/sex-matched HC. Levels of TC, TG, LDL-C, apo-B, and non-HDL negatively correlated with disease duration but positively with laboratory markers of disease activity and the current prednisone equivalent dose. Higher levels of HDL-C were associated with decreased levels of CRP, which is in line with the negative correlation of apo-A levels with CRP, CK, and myoglobin. Conclusions: We have observed significant alterations in serum lipid parameters in our IIM patients compared to healthy age-/sex-matched individuals. Differences were also found among the three IIM subtypes. These alterations were associated with laboratory parameters of disease activity and the current dose of corticosteroids.

Abstract Figure. Results - lipidogram in IIM and HC
Lipid profile analyses of patients with and without type-2 diabetes in a cardiac rehabilitation population
Authors: Mannion J , Nagle N , Wassell G , Brassill MJ 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Type 2 diabetes mellitus (T2DM) can double your risk of coronary artery disease (CAD). SGLT2 inhibitors reduce all-cause mortality for patients with T2DM and CAD, targeting metabolic syndrome components like HbA1c, blood pressure and weight. Lipid profiles are intrinsically linked to obesity however the secondary effects of SGLT2 inhibitors remain unclear, with studies showing a rise in HDLc and LDLc with these medications.

Propose
To compare the effect of cardiac rehabilitation and guideline directed statin therapy on lipid panels of those with diabetes to those without, and to conduct a sub-analysis on SGLT2 inhibited patients to assess for increased HDLc and LDLc.

Methods
We retrospectively reviewed our cardiac rehab records. Data was collected on sequential patients over age 18 who completed cardiac rehab, until 90 diabetics and 90 non-diabetics were identified. Statistical analyses performed using SPSS v.26.

Results
Diabetics had significantly lower total cholesterol, HDL and LDL prior to commencing rehab (Table 1). Diabetics also showed less reduction in total cholesterol and LDL than non-diabetics. Groups had similar follow-up time and anti-lipid therapy. N = 12 (13.3%) diabetics were on SGLT2 inhibitors. This group showed the greatest mean increase of HDL and lowest mean decrease of LDL levels, however, did start with the lowest initial lipid levels.

Conclusions
Diabetics had lower LDL and HDL prior to rehab, which may have led to reduced change in their profiles compared to non-diabetics. Interestingly however, patients on SGLT2 inhibitors showed a trend towards least reduction in mean LDL and the greatest increase in mean HDL compared to other diabetics.
Table 1 Category(Lipids in mmol/L) Non-Diabetics, n = 90 (Mean ± SD) Diabetics, n = 90 (Mean ± SD) p-value SGLT2 cohort, n = 12 (Mean ± SD) Age (Years) 66.1 ± 8.73 67.73 ± 8.88 0.21 66.41 ± 7.8 Max. statin (%) 92.2% 90% 0.16 100% Pre-Total Chol. 4.21 ± 1.29 3.57 ± 0.9 &lt;0.01* 3.36 ± 0.62 Pre-Triglyceride 1.6 ± 0.85 1.87 ± 1.02 0.054 1.63 ± 0.6 Pre-HDL 1.33 ± 0.48 1.12±.029 &lt;0.001* 1.03 ± 0.22 Pre-LDL 2.14 ± 1.03 1.68 ± 0.93 0.002* 1.60 ± 0.57 Change- Total Chol. -0.75 ± 1.13 -0.26 ± 0.09 0.9 -0.09 ± 0.45 Change-HDL -0.01 ± 0.42 +0.03 ± 0.19 0.33 +0.19 ± 0.13 Change- LDL -0.61 ± 0.96 -0.28 ± 0.75 0.01* -0.24 ± 0.63 Lipids rechecked (months) 8.4 ± 0.25 7.9 ± 0.26 0.14 8.25 ± 2.26 Pre-intervention lipid profiles, followed by change in levels over time. *Denotes significance.
The effects of preventive counseling with remote support via e-mail on illness perception in patients with paroxysmal atrial fibrillation after catheter ablation
Authors: Pogosova N , Ovchinnikova AI , Yufereva YM , Sokolova OY , Davtyan KV , Ausheva AK 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Illness perception (IP) affects health behaviors and coping strategies in chronic diseases, but our knowledge about IP in atrial fibrillation (AF) patients (pts) after catheter ablation (CA) is limited.

Purpose
To assess the impact of preventive counseling on IP in pts after AF catheter ablation.

Methods
A prospective randomized controlled study with 2 parallel groups of pts with paroxysmal AF after CA (radiofrequency or cryoablation). Pts were randomized (1:1) into 2 groups. Before discharge, both groups received 1 preventive counseling session with focus on their individual risk factors profile. After discharge pts from intervention group received 6 sessions of biweekly remote preventive counseling via e-mail over the first 3 months. Control group received usual care. IP was assessed using The Brief Illness Perception Questionnaire (BIPQ) at baseline and at 3, 6 and 12 months.

Results
A total of 90 pts aged 35 to 80 years were enrolled (mean age, 57.4 ± 9.9 years, men, 52.2%). The groups were well balanced according to demographic and clinical features. At 6 and 12 months of follow-up there was a significant improvement of the overall IP score in the intervention group vs control (table).

Conclusions
Preventive counseling with remote support via e-mail improves IP in AF pts after CA which may contribute to better long term outcomes.
The overall score of IP Intervention group Control group P for change vs baseline Baseline (points) mean ± SD 42.2 ± 10.2 44.4 ± 9.5 n/s Mе (25%; 75%) 44 (35; 48.5) 45 (37; 51.5) At 3 months (points) mean ± SD 36.8 ± 8.1* 39.7 ± 7.9* 0.055 Mе (25%; 75%) 37 (33; 41) 41 (33.5; 47) Δ% after 3 months, Ме (25%; 75%) -14.3 (-23.2; 5.2) -13.0 (-16.8; -4.6) n/s At 6 months (points) mean ± SD 32.4 ± 7.3* 37.7 ± 8.7* 0.008 Mе (25%; 75%) 33 (27; 38) 37 (31; 44.5) Δ% after 6 months, Ме (25%; 75%) -24.2 (-33.7; -5.9) -18.4 (-24.0; -5.9) 0.040 At 12 months (points) mean ± SD 29.4 ± 7.6* 36.9 ± 8.2* &lt;0.001 Mе (25%; 75%) 29 (24.5; 33.5) 36 (31; 43) Δ% after 12 months, Ме -33.3 (-42.5; -17.1) -18.4 (-26.4; -7.5) &lt;0.001 SD – standard deviation, Me – median;* p &lt;0.001 vs baseline within group
Rising patients" adherence to CVD preventive treatment via medical and psychological counseling using remote technologies
Authors: Kopylova OV , Sirota NA , Yaltonsky VM 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.
Introduction
Low adherence to healthy lifestyle and CVD preventive medical treatment is a seriouse problem in lowering of CVD morbidity and mortality. Using modern medical, psychological and remote technologies may help to increase patients" adherence.
Purpose
To study the efficacy of medical and psychological counselling using remote technologies in rising patients" adherence to CVD preventive treatment.
Methods
The study included 140 patients with risk factors for cardiovascular disease (RF CVD), who were divided into two comparable groups: group of medical and psychological counselling with the use of remote technologies (n = 70) and group of control (n = 70). The study lastet 12 months. Level of adherence was measured via standard Morisky-Green"s 4-item questionnaire as well as via additional questionnaire developed by authors for this study.
Results
Comparative analysis of the level of adherence in the two groups did not reveal statistically significant differences at baseline. After 12 months, the experimental group showed a statistically significant increase in adherence to preventive treatment compared with the control group (р=0,001)
Conclusion(s)
Medical and psychological counselling using remote technologies is an effective method for rising patients" adherence to CVD preventive medical treatment
Cardiac rehabilitation and all-cause mortality in patients with heart failure: A retrospective cohort study
Authors: Buckley B , Harrison S , Fazio-Eynullayeva E , Underhill P , Sankaranarayanan R , Wright D , Thijssen D , Lip G 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Despite the benefits of exercise training in the secondary prevention of cardiovascular disease, there are conflicting findings for the impact of exercise-based cardiac rehabilitation (CR) on mortality for patients with heart failure (HF).

Methods
A retrospective cohort study was conducted which utilised a global federated health research network. Patients with a diagnosis of HF were compared between those with and without an electronic medical record of exercise-based CR within 6-months of a HF diagnosis. Patients with HF undergoing exercise-based CR were propensity score matched to HF patients without exercise-based CR by age, sex, race, co-morbidities, medications, and procedures. We ascertained 2-year incidence of all-cause mortality, hospitalisation, stroke, and atrial fibrillation.

Results
Following propensity score matching, a total of 40,364 patients with HF were identified. Exercise-based CR was associated with 42% lower odds of all-cause mortality (odds ratio 0.58, 95% confidence interval (CI): 0.54-0.62), 26% lower odds of hospitalisation (0.74, 95% CI 0.71-0.77), 37% lower odds of incident stroke (0.63, 95% CI 0.51-0.79), and 53% lower odds of incident atrial fibrillation (0.47, 95% CI 0.4-0.55) compared to matched controls. The beneficial association of exercise-based CR on all-cause mortality was consistent across stratification for sex, older age, included comorbidities, and HF subtype (all P &lt; 0.0001), including patients with HFpEF (0.65, 95% CI 0.60-0.71).

Conclusions
Exercise-based CR was associated with lower odds of all-cause mortality, hospitalisations, incident stroke and incident atrial fibrillation at 2-years follow-up for patients with HF. The beneficial association of CR and lower mortality was consistent for patients with HFrEF and HFpEF.