bluuebunny/crossref_metadata_2025_split huggingface dataset:
l' imaginaire haptique chez Georges Limbour
Authors: Khabou Saadia 
Published: June 2021

Étant nourri par la philosophie phénoménologique, Georges Limbour est sensible aux Texturologies de Jean Dubuffet, qui non seulement font apparaître « la chair du monde » en faisant valoir la « chair de la peinture », mais aussi et paradoxalement deviennent le lieu par excellence où l’imagination matérielle, telle qu’elle est définie par Bachelard, trouve sa parfaite illustration. Ce qui fait que la contemplation d’une toile de Dubuffet déclenche chez Limbour une suite d’images fantasmagoriques, attestant de la puissance haptique de ces Texturologies et de leur aptitude à faire advenir l’absence à travers la forte présence de la matière picturale.
L’intérêt de cet article est de montrer comment le changement du paradigme pictural, qui marque le passage de la transparence iconique à l’opacité indicielle, permet paradoxalement d’ancrer plus concrètement le fait pictural dans l’expérience immanente du monde sensible et de créer par de-là même un imaginaire haptique qui fera la singularité de l’œuvre littéraire de Georges Limbour.
PENGARUH BUDAYA ORGANISASI TERHADAP EMPLOYEE ENGAGEMENT PADA KARYAWAN BAAK UNIVERSITAS XYZ DI JAKARTA
Authors: Tabun Melkianus Albin 
Published: June 2021

Penelitian ini dilakukan pada karyawan BAAK Universitas XYZ di Jakarta dengan tujuan untuk mengetahui sejauh mana pengaruh budaya organisasi terhadap keterlibatan karyawan (employee engagement). Populasi dalam penelitian ini adalah seluruh karyawan BAAK Universitas XYZ di Jakarta yang berjumlah 35 orang. Teknik pengambilan sampelnya menggunakan teknik sampling jenuh, karena jumlah populasi dalam penelitian ini relatif kecil sehingga seluruh karyawan BAAK Universitas XYZ di Jakarta yang berjumlah 35 orang karyawan dipilih menjadi sampel. Metode pengumpulan data menggunakan kuesioner online (google form). Metode analisis data menggunakan analisis deskriptif dan analisis regresi linear sederhana. Adapun hasil analisisnya adalah: hasil analisis deskriptif terhadap variabel budaya organisasi dan employee engagement menunjukkan rata-rata skor yang tinggi, artinya semakin baik budaya organisasi pada karyawan, semakin tinggi pula employee engagement-nya. Hasil pengujian hipotesis (uji t) menunjukkan bahwa budaya organisasi berpengaruh positif dan signifikan terhadap employee engagement pada karyawan BAAK Universitas XYZ di Jakarta karena diketahui nilai thitung (5,035) > ttabel (2,034) dan nilai signifikansinya sebesar 0,000 < 0,05. Dan hasil pengujian koefisien determinasi (R2) juga menunjukkan bahwa sumbangan pengaruh dari variabel budaya organisasi terhadap employee engagement pada karyawan BAAK Universitas XYZ di Jakarta adalah sebesar 43,4%.
Kata kunci: Budaya Organisasi; Employee Engagement
A comparative study of three conventional methods for diagnosis urinary schistosomiasis.
Authors: O Abosalif K , A Ahmed A , M Shammat I , S Aljafari A , A Afifi A , Shiff Clive J 
Published: June 2021

The general objective of this comparative study was the evaluation of three diagnostic techniques (sedimentation technique using centrifugation, filtration techniques using millipore filter and Ninhydrine stained filter paper) conventional approaches. This was carried out at Alzaidab, River Nile State, Northern Sudan on 93 school children. The study involved the collection of samples from school children of 7 years age and above. A questionnaire was distributed to collect data on gender, age and water contact activities. The examinations on all samples were carried out applying the methods previously mentioned. The results revealed that the overall prevalence rates of Schistosomahaematobium in Alzaidab Nile State were 16.1%, 24.7% and 24.7% using the centrifugation, syringe filtration millipore, ninhydrin – filter paper staining method respectively. According to gender, males showed higher prevalence rates than females using all the techniques mentioned and the highest prevalence rate in males (36.1%) was reported by the syringe filtration millipore and ninhydrin – filter paper staining method. According to age groups, the highest prevalence rate was reported among the group of children over 13 years of age, using all the techniques. The high prevalence rate (64.3%) among the above mentioned group (over 13 year’s of age) was shown by the syringe filtration millipore and ninhydrin – filter paper staining method. The highest prevalence among those who had water contact (32.9%) was shown by the syringe filtration millipore and ninhydrin – filter paper staining method.It was found that the syringe filtration millipore and ninhydrin – filter paper staining methods gave identical and reproducible results, yet the ninhydrin – filter paper staining does not fit for field practice since it can only be carried out in the laboratory.
Pemanfaatan Teknologi Melalui Pelatihan Penggunaan Aplikasi Google Site bagi Guru MGMP Matematika SMP Kabupaten Cirebon
Authors: Aminah Neneng , Amami Surya , Wahyuni Ika , Rosita Cita Dwi 
Published: June 2021

Komputer sebagai media pembelajaran memiliki keunggulan-keunggulan dalam presentasi grafik dengan tampilan yang menarik, yang dapat dimanipulasi secara leluasa dalam bentuk representasi visual model matematika. Salah satu jenis media yang tepat dalam proses pembelajaran yaitu Aplikasi Google Site. Perangkat lunak dinamis merupakan media yang dapat memberikan kesempatan pada guru untuk meningkatkan kemampuan dalam mengajar matematika. Tujuan kegiatan PKM ini adalah memberikan pelatihan penggunaan pemanfaatan google site untuk pengajaran maupun administrasi para guru di sekolah, Metode pendekatan yang digunakan untuk mengatasi permasalahan yang dihadapi mitra adalah dengan cara mengadakan pelatihan, dan pendampingan, terkait mendesain bahan ajar berbasis literasi matematis. Target khusus dari kegiatan PKM ini adalah bertambahnya pengetahuan guru matematika SMP Kabupaten Cirebon dalam pemanfaatan google site yang selama ini dirasakan jarang ada yang menggunakan karena ketidaktahuan fungsinya. Hasil kegiatan yang telah dilaksanakan semua guru mampu mengoperasikan dan memanfaatkan google site, kegiatan menghasilkan pengetahuan bagi guru.
The European obession with food indications
Authors: Polčák Radim 
Published: June 2021

Besides trademarks, there are a number of different legal instruments protecting food indications in Europe. By their very nature, these food indications act like intellectual property, while their primary purpose, it is claimed, is to protect consumers. The paper focuses on the theoretical teleology of food indication law and compares it to the actual local, European and international legal, economic and technical effects. It analyses these types of indications that are specifically implemented in European law, i.e. Protected Designations of Origin (PDO), Protected Geographical Indications (PGI) and Traditional Specialties Guaranteed (TSG).
Incidence and mortality trends of metastatic prostate cancer: Surveillance, Epidemiology, and End Results database analysis
Authors: Zhang Aaron C. , Rasul Rehana , Golden Anne , Feuerstein Michael A. 
Published: June 2021

Introduction: In the past decade, prostate cancer screening decreased, raising the concern of delays in diagnosis and leading to increase in new cases of metastatic prostate cancer. This study evaluated whether these changes may have impacted trends in metastatic prostate cancer incidence and survival.
Methods: Metastatic prostate cancer diagnoses from 2008–2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) 18 registries. Age-adjusted incidence rates per 100 000 were calculated by time periods and demographic variables. Two-year all-cause and prostate cancer-specific mortality were calculated for patients diagnosed from 2008–2014, and multivariable Cox proportional hazards models were used to evaluate the impact of demographic and clinical variables.
Results: Incidence rates of metastatic prostate cancer increased by 18% from 2008–2009 to 2014–2016 (Incidence rate ratio [IRR]=1.18, 95% confidence interval [CI] 1.14–1.21). This trend was observed across multiple subgroups but was greatest in non-Hispanic Whites and patients living in counties 0–10% below poverty level. There was an overall decreased risk of all-cause and prostate cancer-specific mortality, but unmarried men and men living in counties >20% below poverty level showed statistically significant increased risk of prostate cancer-specific mortality.
Conclusions: Non-Hispanic Whites and the wealthiest subgroups had the largest increase in incidence of metastatic prostate cancer since 2008. Despite trends of decreased risk of prostate cancer-specific mortality, we found certain populations experienced increases in mortality risk. Studies exploring the role of socioeconomic factors on screening and access to newer treatments are needed.
The evolving role of germline genetic testing and management in prostate cancer: Report from the Princess Margaret Cancer Centre International Retreat
Authors: Clark Roderick , Kenk Miran , McAlpine Kristen , Thain Emily , Farncombe Kirsten M. , Pritchard Colin C. , Nussbaum Robert , Wyatt Alexander W. , De Bono Johann , Vesprini Danny , Bombard Yvonne , Lorentz Justin , Narod Steven , Kim Raymond , Fleshner Neil 
Published: June 2021

Introduction: Prostate cancer is a significant cause of cancer mortality. It has been well-established that certain germline pathogenic variants confer both an increased risk of being diagnosed with prostate cancer and dying of prostate cancer.1 There are exciting developments in both the availability of genetic testing and opportunities for improved treatment of patients. On August 19, 2020, the Princess Margaret Cancer Centre in Toronto, Ontario, hosted a virtual retreat, bringing together international experts in urology, medical oncology, radiation oncology, medical genetics, and translational research, as well as a patient representative. We are pleased to provide this manuscript as a review of those proceedings for Canadian clinicians.
Recommendations: We drafted several recommendations for future research and policy action based on this meeting:
1) Need for increased access to funding for germline testing for the common genetic disorders associated with increased risk of prostate cancer.
2) A need for increased research into identifying genetic factors influencing risk stratification, treatment response, and outcomes of prostate cancer within Canadian populations at increased genetic risk for prostate cancer.
3) Need for increased awareness about genetic risk factors among the Canadian public.
4) Need for research on patient perspectives and psychosocial outcomes in individuals identified to be at increased genetic risk of prostate cancer.
5) We support the creation of specialized multidisciplinary clinics that specialize in tailored care for patients at increased genetic risk of prostate cancer.
Syzygium cumini Mediated Green Synthesis of Silver Nanoparticles for Reduction of 4-Nitrophenol and Assessment of Its Antibacterial Activity
Authors: R. Waghmode Samadhan , A. Dudhane Amol , P. Mhaindarkar Vaibhav 
Published: June 2021

The biosynthesis of silver nanoparticles (AgNPs) has become more significant in the recent years owing to its applications in catalysis, imaging, drug delivery, nano-device fabrication and in medicine. We propose the synthesis of silver nanoparticles from the plant extract of Syzygium cumini and evaluation of its antibacterial and chemocatalytic potential. Synthesis of AgNPs carried out by using aqueous silver nitrate. The UV–Vis absorption spectrum of the synthesized AgNPs showed a broad absorption peak at 470 nm. TEM analysis shows the morphology of AgNPs as a hexagonal matrix with average particle size is about 50 nm. XRD analysis displays the crystalline structure of AgNPs. The presence of elemental silver was confirmed with EDX analysis. FTIR analysis shows that amide groups present in proteins are dominant reducing agents and play an important role in the bioreduction of Ag+ ions to Ag0. The bioreduced AgNPs demonstrated significant catalytic properties in a reduction reaction of 4-nitrophenol to 4-aminophenol using NaBH4 in an aqueous condition. The biosynthesized AgNPs have potent antibacterial activity against common clinical pathogens. Considering the remarkable antibacterial activity against common pathogenic microorganisms, AgNPs can be used in the pharmaceutical industries.
Nanomagnetic Polymeric Absorbent Based on Alginate and Gamma-Maghemite Synthesized In Situ for Wastewater Treatment from Metallurgical Industry
Authors: Lourenço de Mello Ferreira Ivana , Ferreira Bittencourt Rodrigo , Sousa Júnior Clenilson 
Published: June 2021

A nanomagnetic absorbent based on calcium alginate was produced successfully with the maghemite nanoparticles synthesized in situ, i.e., together with the polysaccharide crosslinking reaction. Physicochemical properties of the absorbent were analyzed and its ability to remove Ni(II) and Mn(II) ions from a real metallurgical industry wastewater was evaluated. Kinetic studies of the adsorption of these heavy metals were realized. To ascertain the most suitable quantity of absorbent to remove Ni(II) and Mn(II) from the wastewater, the absorbent mass was varied and adsorption kinetics was also evaluated. The competitiveness between the metals was evaluated to understand the adsorption mechanism. The samples were characterized by transmission electron microscopy, vibrating sample magnetometry, X-ray diffractometry and Mössbauer spectroscopy. The absorbent prepared, in this work, can be classified as a hydrogel. It presented predominant spherical morphology and micrometric dimension, containing atoms of iron and calcium dispersed uniformly in their internal and external surfaces. The synthesized maghemite nanoparticles presented superparamagnetic behavior. Results showed that the adsorption equilibrium time for both ions was about 60 min. The removal percentages from wastewater were 60.5% for nickel and 56.6% for manganese, using 300 mg of hydrogel. Results revealed that the adsorption mechanism is by ionic change between calcium and heavy metals.
Meta-analysis of Technical Efficiency in Selected Agricultural Sub-sectors: Implications for Policy Making in Developing Countries like Sri Lanka
Authors: Senevirathne S. M. P. , Hettiarachchi M. H. S. M. , Dilrukshi R. P. W. A. , Kumara G.D. Kapila , Ampitiyawatta A. D. , Beneragama C. K. 
Published: June 2021

Aims: To evaluate the technical efficiency (TE) in selected agricultural sub-sectors and to propose possible policy interventions to the government with the aim of reducing the poverty of farmers in the developing world.
Study design: A meta-analysis based on empirical studies conducted by various scientists throughout the developing world.
Methodology: Research articles for the meta-analysis were selected using a thorough screening process based on the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) concept. Selected 94 articles were sub-divided in to three main agriculture sub-sectors for detailed analysis; (a) paddy, other field crops-OFC and vegetables, (b) fruits, and (c) livestock. Mean TE of each crop or livestock type was calculated by averaging the TE values for a particular crop or livestock type across different studies included in this study.
Results: TE data presented in the original articles showed a considerable dispersion within a given study. The highest mean TE was recorded in B-onion (0.83±0.15) whereas the lowest was recorded in maize (0.703±0.09) and in soybean (0.705±0.13). The TE of chili cultivation was 0.78 with the greatest variability (standard error of mean [SEM] 0.19) among the crops considered, which signifies the unpredictable nature of the chili cultivation. Mango was found to be the least technically efficient crop among the studied, with a mean TE of 0.596±0.11. Dairy, poultry and aquaculture farming operations were found to be highly technically efficient having mean TE values of 0.80±0.16, 0.89±0.02 and 0.88±0.08 respectively.
Conclusion: Findings of this study will lead to several key policy implications including, improvement of the socioeconomic characteristics of farmers, implementation of farmer field schools (FFS) and establishment of a cautious and gradual strategy for expansion of the rural financial institutions.
The potential of cord blood to replenish young immune cells against cancer
Authors: Li Xiaoyang , Cheng Lin , Li Junmin , Ren Ruibao 
Published: June 2021

AbstractThe immune system of elderly individuals behaves differently from young adults, leading to a general assumption that the decline of immune system function increases the susceptibility to infectious and noninfectious diseases. This age‐related internal immune function failure, termed "immune senescence," contributes to the increment of morbidity and mortality associated with diseases in elderly populations. Cord blood is considered as a source of “young” immune cells for anti‐infectious immunity and adoptive cancer immunotherapy. In this review, we describe immune aging and the application of cord blood for replenishing aging immune cells against neoplastic diseases.
Does writing enhance recall and memory consolidation? Revealing the factor of effectiveness of the self‐administered interview
Authors: Miura Hiroshi , Matsuo Kayo 
Published: June 2021

SummaryThe self‐administered interview (SAI©) is a booklet in which eyewitnesses write down their memories of an incident without assistance. The SAI can gather a significant amount of eyewitness information, and completing the SAI soon after witnessing an event can improve later recall. This study aimed to reveal the factor of effectiveness of the SAI and specifically focused on the method of handwriting. Participants watched a video and immediately recalled the event in the three conditions: SAI‐writing, SAI‐speaking, and free recall (speaking). One week later, participants again recalled the event via free recall. The results showed that participants in the SAI‐writing condition reported more correct information than those in the other conditions at both time points. This suggests that a factor of effectiveness of the SAI is the method of writing. Thus, initial written recall using the SAI could facilitate later recall in police investigative interviews.
Feasibility of a deep learning‐based algorithm for automated detection and classification of nasal polyps and inverted papillomas on nasal endoscopic images
Authors: Girdler Benton , Moon Hyun , Bae, Mi Rye , Ryu Sung Seok , Bae Jihye , Yu Myeong Sang 
Published: June 2021

AbstractBackgroundDiscrimination of nasal cavity mass lesions is a challenging work requiring extensive experience. A deep learning‐based automated diagnostic system may help clinicians to classify nasal cavity mass lesions. We demonstrated the feasibility of a convolutional neural network (CNN)‐based diagnosis system for automatic detection and classification of nasal polyps (NP) and inverted papillomas (IP).MethodsWe developed a CNN‐based algorithm using a transfer learning strategy and trained it on nasal endoscopic images. A total of 99 nasal endoscopic images with normal findings, 98 images with NP, and 100 images with IP were analyzed using the developed CNN. Six otolaryngologists participated in clinical visual assessment. Image‐based classification performance was measured by calculating the accuracy and area under the receiver operating characteristic curve (AUC). The diagnostic performance was compared between the CNN and clinical visual assessment by human experts.ResultsThe algorithm achieved an overall accuracy of 0.742 ± 0.058 with the following class accuracies: normal, 0.81± 0.14; IP, 0.57 ± 0.07; and NP, 0.83 ± 0.21. The AUC values for normal, IP, and NP were 0.91 ± 0.06, 0.82 ± 0.09, and 0.84 ± 0.06, respectively. The overall accuracy of the CNN model was comparable with the average performance of human experts (0.742 vs. 0.749; p = 0.11).ConclusionsThe trained CNN model appears to reliably classify NP and IP of the nasal cavity from nasal endoscopic images; it also yields a reliable reference for diagnosing nasal cavity mass lesions during nasal endoscopy. However, further studies with more test data are warranted to improve the diagnostic accuracy of our CNN model.
Converting the 3‐quinuclidinone reductase from Agrobacterium tumefaciens into the ethyl 4‐chloroacetoacetate reductase by site‐directed mutagenesis
Authors: Liu Di , Gou Linbo , Bai Yajun , Fan Tai‐Ping , Zheng Xiaohui , Cai Yujie 
Published: June 2021

AbstractIn this study, the 3‐quinuclidinone reductase from Agrobacterium tumefaciens (AtQR) was modified by site‐directed mutagenesis. And we further obtained a saturation mutant library in which the residue 197 was mutated. A single‐point mutation converted the wild enzyme that originally had no catalytic activity in reduction of ethyl 4‐chloroacetoacetate (COBE) into an enzyme with catalytic activity. The results of enzyme activity assays showed that the seven variants could asymmetrically reduce COBE to ethyl (S)‐4‐chloro‐3‐hydroxybutyrate ((S)‐CHBE) with NADH as coenzyme. In the library, the variant E197N showed higher catalytic efficiency than others. The E197N was optimally active at pH 6.0 and 40°C, and the catalytic efficiency (kcat/Km) for COBE was 51.36 s–1·mM–1. This study showed that the substrate specificity of AtQR could be changed through site‐directed mutagenesis at the residue 197.
Reshaping cell line development and CMC strategy for fast responses to pandemic outbreak
Authors: Zhang Zheng , Chen Ji , Wang Junghao , Gao Qiao , Ma Zhujun , Xu Shurong , Zhang Li , Cai Jill , Zhou Weichang 
Published: June 2021

AbstractThe global pandemic outbreak COVID‐19 (SARS‐COV‐2), has prompted many pharmaceutical companies to develop vaccines and therapeutic biologics for its prevention and treatment. Most of the therapeutic biologics are common human IgG antibodies, which were identified by next‐generation sequencing (NGS) with the B cells from the convalescent patients. To fight against pandemic outbreaks like COVID‐19, biologics development strategies need to be optimized to speed up the timeline. Since the advent of therapeutic biologics, strategies of transfection and cell line selection have been continuously improved for greater productivity and efficiency. NGS has also been implemented for accelerated cell bank testing. These recent advances enable us to rethink and reshape the chemistry, manufacturing, and controls (CMC) strategy in order to start supplying Good Manufacturing Practices (GMP) materials for clinical trials as soon as possible. We elucidated an accelerated CMC workflow for biologics, including using GMP‐compliant pool materials for phase I clinical trials, selecting the final clone with product quality similar to that of phase I materials for late‐stage development and commercial production.
A case of bullous pemphigoid after a long‐term administration of anti‐PD‐1 antibodies in a patient with non‐small‐cell lung cancer
Authors: Yokoyama Emi , Yamasaki Osamu , Kubo Toshio , Koga Hiroshi , Ishii Norito , Morizane Shin 
Published: June 2021

We described a case of BP that developed 2.5 years after the administration of nivolumab for metastatic non‐small cell lung cancer. Our report highlights the fact that dermatologists should be aware of anti PD‐1‐related BP, which can appear very late during treatment.