bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visceral Hepatic Leishmaniasis in a Melanoma Patient in FDG-PET
Authors: Dunzinger Andreas , Datinger Carina , Loidl Almute , Walcherberger Bernhard , Lengauer Roland Andreas , Mehraban Nariman , Pichler Robert 
Published: July 2021

Background:
Leishmaniasis is caused by protozoans that depend on female phlebotomine
sandflies as vectors. The natural habitat of these sandflies is changing due to climatic
changes, affecting the immunocompromised population, as more patients get immunocompromised
due to cancer therapy in the present time.

Case report:
We report the case of a 72-year-old patient with melanoma in whom we found visceral
leishmaniasis mimicking hepatic metastasis in routine FDG-PET/CT. The patient was hospitalised
due to fever and pancytopenia in the general hospital Steyr. The diagnosis was made by
biopsy of the iliac crest with cytological study and polymerase chain reaction. After treatment with
amphotericin B, the patient recovered and tests became negative, including FDG-PET/CT. Because
of climate change and the increasing use of immunomodulatory medication, our awareness of such
findings should grow.

Conclusion:
New pitfalls in diagnosis and surveillance of cancer patients because of altered environmental
conditions and immunocompromised patients have to be taken into account.
Identification of the First “Two Digit Nano-molar” Inhibitors of the Human Glyoxalase-I Enzyme as Potential Anticancer Agents
Authors: Al‑Balas Qosay A. , Al-Sha'er Mahmoud A. , Hassan Mohammad A. , Al Zou’bi Esra’a 
Published: July 2021

Background:
Glyoxalase-I (Glo-I) enzyme is recognized as an indispensable druggable target in cancer treatment. Its inhibition will lead to the accumulation of toxic aldehyde metabolites and cell death. Paramount efforts were spent to discover potential competitive inhibitors to eradicate cancer.

Objective:
Based on our previously work on this target for discovering potent inhibitors of this enzyme, herein, we address the discovery of the most potent Glo-I inhibitors reported in literature with two digits nano-molar activity.

Methods:
Molecular docking and in vitro assay were performed to discover these inhibitors and explore the active site's binding pattern. A detailed SAR scheme was generated, which identifies the significant functionalities responsible for the observed activity.

Results:
Compound 1 with an IC50 of 16.5 nM exhibited the highest activity, catechol moiety as an essential zinc chelating functionality. It has been shown by using molecular modeling techniques that the catechol moiety is responsible for the chelation zinc atom at the active site, an essential feature for enzyme inhibition.

Conclusion:
Catechol derivatives are successful zinc chelators in the Glo-I enzyme while showing exceptional activity against the enzyme to the nanomolar level.
Ascorbic Acid in Epigenetic Reprogramming
Authors: Liu Xinhui , Khan Aamir , Li Huan , Wang Shensen , Chen Xuechai , Huang Hua 
Published: July 2021

:
Emerging evidence suggests that ascorbic acid (vitamin C) enhances the reprogramming
process by multiple mechanisms primarily due to its cofactor role in Fe(II) and 2-oxoglutarate-dependent
dioxygenases, including the DNA demethylases Ten Eleven Translocase (TET) and histone
demethylases. Epigenetic variations have been shown to play a critical role in somatic cell reprogramming.
DNA methylation and histone methylation are extensively recognized as barriers to
somatic cell reprogramming. N6-methyladenosine (m6A), known as RNA methylation, is an epigenetic
modification of mRNAs and has also been shown to play a role in regulating cellular reprogramming.
Multiple cofactors are reported to promote the activity of these demethylases, including
vitamin C. Therefore, this review focuses and examines the evidence and mechanism of vitamin C
in DNA and histone demethylation and highlights its potential involvement in the regulation of
m6A demethylation. It also shows the significant contribution of vitamin C in epigenetic regulation,
and the affiliation of demethylases with vitamin C-facilitated epigenetic reprogramming.
• Introduction
• Vitamin C, DNA Demethylation, and Epigenetic Reprogramming
• Vitamin C, Histone demethylation, and Epigenetic Reprogramming
• Vitamin C, m6A RNA demethylation and Epigenetic Reprogramming
• Conclusion
Barriers to the Use of Web-Based Mental Health Programs for Preventing Depression: Qualitative Study
Authors: Eccles Heidi , Nannarone Molly , Lashewicz Bonnie , Attridge Mark , Marchand Alain , Aiken Alice , Ho Kendall , Wang JianLi 
Published: July 2021

Background
Depression has a profound impact on population health. Although using web-based mental health programs to prevent depression has been found to be effective in decreasing depression incidence, there are obstacles preventing their use, as reflected by the low rates of use and adherence.

Objective
The aims of the study are to understand the barriers to using web-based mental health programs for the prevention of depression and the possible dangers or concerns regarding the use of such programs.

Methods
BroMatters and HardHat were two randomized controlled trials (RCTs) that evaluated the effectiveness of e–mental health programs for preventing workplace depression. In the BroMatters RCT, only working men who were at high risk of having a major depressive episode were included. The participants were assigned to either the control group or 1 of 2 intervention groups. The control participants had access to the general depression information on the BroMatters website. Intervention group 1 had access to BroMatters and BroHealth—the depression prevention program. Intervention group 2 had access to BroMatters and BroHealth along with weekly access to a qualified coach through telephone calls. The HardHat trial targeted both men and women at high risk of having a major depressive episode. The participants in the intervention group were given access to the HardHat depression prevention program (which included a web-based coach), whereas HardHat access was only granted to the control group once the study was completed. This qualitative study recruited male participants from the intervention groups of the two RCTs. A total of 2 groups of participants were recruited from the BroMatters study (after a baseline interview: n=41; 1 month after the RCT: n=20; 61/744, 8.2%), and 1 group was recruited from the HardHat RCT 1 month after the initial quantitative interview (9/103, 8.7%). Semistructured interviews were performed with the participants (70/847, 8.3%) and analyzed using content analysis.

Results
There were both personal and program-level barriers to program use. The three personal barriers included time, stress level, and the perception of depression prevention. Content, functionality, and dangers were the program-level barriers to the use of web-based mental health programs. Large amounts of text and functionality issues within the programs decreased participants’ engagement. The dangers associated with web-based mental health programs included privacy breaches and inadequate help for severe symptoms.

Conclusions
There are personal and program-level barriers to the use of web-based mental health programs. The stigmatization of help seeking for depression symptoms affects the time spent on the program, as does the public perception of depression. Certain barriers may be mitigated by program updates, whereas others may require a complete shift in the perception of depression prevention.
Upper-Limb Motion Recognition Based on Hybrid Feature Selection: Algorithm Development and Validation
Authors: Li Qiaoqin , Liu Yongguo , Zhu Jiajing , Chen Zhi , Liu Lang , Yang Shangming , Zhu Guanyi , Zhu Bin , Li Juan , Jin Rongjiang , Tao Jing , Chen Lidian 
Published: July 2021

Background
For rehabilitation training systems, it is essential to automatically record and recognize exercises, especially when more than one type of exercise is performed without a predefined sequence. Most motion recognition methods are based on feature engineering and machine learning algorithms. Time-domain and frequency-domain features are extracted from original time series data collected by sensor nodes. For high-dimensional data, feature selection plays an important role in improving the performance of motion recognition. Existing feature selection methods can be categorized into filter and wrapper methods. Wrapper methods usually achieve better performance than filter methods; however, in most cases, they are computationally intensive, and the feature subset obtained is usually optimized only for the specific learning algorithm.

Objective
This study aimed to provide a feature selection method for motion recognition of upper-limb exercises and improve the recognition performance.

Methods
Motion data from 5 types of upper-limb exercises performed by 21 participants were collected by a customized inertial measurement unit (IMU) node. A total of 60 time-domain and frequency-domain features were extracted from the original sensor data. A hybrid feature selection method by combining filter and wrapper methods (FESCOM) was proposed to eliminate irrelevant features for motion recognition of upper-limb exercises. In the filter stage, candidate features were first selected from the original feature set according to the significance for motion recognition. In the wrapper stage, k-nearest neighbors (kNN), Naïve Bayes (NB), and random forest (RF) were evaluated as the wrapping components to further refine the features from the candidate feature set. The performance of the proposed FESCOM method was verified using experiments on motion recognition of upper-limb exercises and compared with the traditional wrapper method.

Results
Using kNN, NB, and RF as the wrapping components, the classification error rates of the proposed FESCOM method were 1.7%, 8.9%, and 7.4%, respectively, and the feature selection time in each iteration was 13 seconds, 71 seconds, and 541 seconds, respectively.

Conclusions
The experimental results demonstrated that, in the case of 5 motion types performed by 21 healthy participants, the proposed FESCOM method using kNN and NB as the wrapping components achieved better recognition performance than the traditional wrapper method. The FESCOM method dramatically reduces the search time in the feature selection process. The results also demonstrated that the optimal number of features depends on the classifier. This approach serves to improve feature selection and classification algorithm selection for upper-limb motion recognition based on wearable sensor data, which can be extended to motion recognition of more motion types and participants.
Factors Influencing Implementation of eHealth Technologies to Support Informal Dementia Care: Umbrella Review
Authors: Bastoni Sofia , Wrede Christian , da Silva Marcia Cristina , Sanderman Robbert , Gaggioli Andrea , Braakman-Jansen Annemarie , van Gemert-Pijnen Lisette 
Published: July 2021

Background
The worldwide increase in community-dwelling people with dementia underscores the need for innovative eHealth technologies that aim to provide support to both patients and their informal caregivers in the home setting. However, sustainable implementation of eHealth technologies within this target group can be difficult.

Objective
The goal of this study was to gain a thorough understanding of why it is often difficult to implement eHealth technologies in practice, even though numerous technologies are designed to support people with dementia and their informal caregivers at home. In particular, our study aimed to (1) provide an overview of technologies that have been used and studied in the context of informal dementia care and (2) explore factors influencing the implementation of these technologies.

Methods
Following an umbrella review design, five different databases were searched (PubMed, PsycINFO, Medline, Scopus, and Cochrane) for (systematic) reviews. Among 2205 reviews retrieved, 21 were included in our analysis based on our screening and selection procedure. A combination of deductive and inductive thematic analyses was performed, using the Nonadoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) framework for organizing the findings.

Results
We identified technologies designed to be used “by informal caregivers,” “by people with dementia,” and “with people with dementia.” Within those groups, most of the represented technologies included, respectively: (i) devices for in-home monitoring of lifestyle, health, and safety; (ii) technologies for supporting memory, orientation, and day structure; and (iii) technologies to facilitate communication between the informal caregiver and person with dementia. Most of the identified factors influencing implementation related to the condition of dementia, characteristics of the technology, expected/perceived value of users, and characteristics of the informal caregiver. Considerably less information has been reported on factors related to the implementing organization and technology supplier, wider institutional and sociocultural context of policy and regulations, and continued adaptation of technology over time.

Conclusions
Our study offers a comprehensive overview of eHealth technologies in the context of informal dementia care and contributes to gaining a better understanding of a broad range of factors influencing their implementation. Our results uncovered a knowledge gap regarding success factors for implementation related to the organizational and broader context and continuous adaptation over the long term. Although future research is needed, the current findings can help researchers and stakeholders in improving the development and implementation of eHealth technologies to support informal dementia care.
A CRITICAL STEP FOR THE COSMETIC INDUSTRY: SCALE-UP
Authors: DURGUN Meltem Ezgi , YAPAR Evren ALGIN 
Published: July 2021

The perception of aesthetics directs the daily life of people from ancient times to the present. While the desire to be beautiful turns into a passion for some, it can also become a medical necessity for some people, such as war veterans. The historical documents examined show that both men and women use different materials to change their appearance and/or protect their skin. These materials still lead the way in the development of today's cosmetic products. The cosmetics industry is an important business line developed based on this aesthetic perception of societies.Starting from the research and development (R&D) process of a cosmetic formulation and becoming a final product, health authorities control the industry by various regulations. In this process, where each step must be meticulously fulfilled, perhaps the most critical step is the scale-up process. In this review, cosmetic products, scale-up and critical parameters in scale-up process are discussed.

Peer Review History:
Received: 7 May 2021; Revised: 16 June; Accepted: 23 June, Available online: 15 July 2021
Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Dr. Salfarina Ramli, salfarina2892@uitm.edu.my Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
Dr. Govind Vyas, Compliance & Regulatory Officer Inva-Tech Pharmaceuticals LLC, New-Jersey, USA, govindvyas03@gmail.com

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Black Cumin (Nigella sativa) Against Mycobacterium tuberculosis Strain H37RV And MDR-TB
Authors: Masri Mashuri , Muthiadin Cut , Masita Masita , Cahyanto Tri , Lianah Lianah , Rusny Rusny , Tridesianti Siska 
Published: July 2021

Abstract: Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. 10 million people suffer from TB Every year. Although TB is a preventable and treatable disease, 1.5 million people die every year due to TB. Alternative treatments continue to be pursued, and treatment with the latest TB drugs that are continuously being encouraged. Black cumin (Nigella sativa) seed contains essential oils with active compounds such as thymohydroquinone, Oleoresins, flavonoids, alkaloids, saponins, tannins, and terpenoids that act as antibacterial drugs. This study aims to determine the sensitivity of N. sativa seed extract in inhibiting the growth of M. tuberculosis strain H37RV and MDR-TB (Multidrug Resistance-TB). This research using Microscopic-Observation and Drug-Susceptibility Assay (MODS) method. Extraction of N. sativa was carried out by the maceration method using 70% methanol as a solvent. The results showed that the M. tuberculosis strain H37RV and MDR-TB were sensitive to N. sativa extract at concentrations of 5 and 10% but resistant to N. sativa extract at concentrations of 1 and 3%.Abstrak: Tuberkulosis (TB) adalah penyakit menular yang disebabkan oleh Bakteri Mycobacterium tuberculosis. Penyakit ini menimbulkan dampak kematian yang cukup mengkhawatirkan. Penyakit tersebut dapat dicegah dan diobati. Salah satu sumber pengobatannya menggunakan biji jintan hitam (Nigella sativa) yang mengandung minyak atsiri dengan senyawa aktif seperti timohidrokuinon, oleoresin, flavonoid, alkaloid, saponin, tanin, dan terpenoid yang berfungsi sebagai obat antibakteri. Penelitian ini bertujuan untuk mengetahui sensitivitas ekstrak biji N. sativa dalam menghambat pertumbuhan M. tuberculosis strain H37RV and MDR-TB (Multidrug-Resistance-TB). Penelitian ini menggunakan metode Microscopic-Observation and Drug-Susceptibility Assay (MODS). Ekstraksi N. sativa dilakukan dengan metode maserasi menggunakan pelarut metanol 70%. Hasil yang diperoleh menunjukkan bahwa bakteri M. tuberculosis strain H37RV dan TB-MDR, kedua strain tsb sensitif terhadap ekstrak N. sativa konsentrasi 5 dan 10%, tetapi resisten terhadap ekstrak N. sativa konsentrasi 1 dan 3%.
Rekonstruksi Subjek dan Peristiwa Hukum Akad Pembiayaan Murabahah pada Perbankan Syariah
Authors: Dayyan Muhammad 
Published: July 2021

This article argues that the murabahah contract implemented by Islamic banking with reference to the DSN-MUI fatwa and the Murabahah SOP formulated by the OJK is still ambiguous in terms of the pillars of both legal actions (legal events) and subjects (actors) of a series of legal events. Whereas financing with murabahah is very dominantly practiced by banks in channeling their funds to the public. This has spawned a number of studies that see many sides of weakness and even conflict with sharia principles. By using the ushul fiqh approach and using primary and secondary legal materials, the authors conduct a content analysis offering reconstruction of murabahah financing contracts in Islamic banking. The results of this study found that the murabahah financing contract was eleven legal events and four subjects were perpetrators of legal acts. These eleven legal events must be included as a new pillar of the murabahah financing agreement as an instrument for realizing maslahah and economic distributive justice. Artikel ini beragumen bahwa akad murabahah yang diterapkan oleh perbankan syariah dengan mengacu pada fatwa DSN-MUI dan SOP Murabahah yang dirumuskan oleh OJK masih ambingu dari segi rukun baik perbuatan hukum (peristiwa hukum) maupun subjek (pelaku) dari serangkaian peristiwa hukum. Padahal pembiayaan dengan murabahah sangat dominan dipraktekkan oleh perbankan dalam menyalurkan dananya kepada masyarakat. Hal ini telah melahirkan sejumlah penelitian yang melihat banyak sisi kelemahan bahkan bertentangan dengan prinsip syariah. Dengan menggunakan pendekatan ushul fiqh dan menggunakan bahan hukum primer dan sekunder, penulis melakukan content analysis menawarkan rekonstruksi akad pembiayaan murabahahpada perbankan syariah. Hasil penelitian ini menemukan akad pembiayaan murabahah sebelas peristiwa hukum dan empat subjek pelaku perbuatan hukum. Kesebelas peristiwa hukum ini harus dimasukkan sebagai rukun baru dari akad pembiayaan murabahah sebagai instrument untuk merelaisasikan maslahah dan keadilan distributif ekonomi.
Simulación de una antena microcinta rectangular espiral multibanda para la aplicación de captación de energía de radiofrecuencia
Authors: Zapata-Ochoa Edison Andrés , López-Giraldo Francisco , Goéz Germán David 
Published: July 2021

El presente estudio realizó un análisis de la influencia que ejercen las variaciones del grosor del sustrato dieléctrico y de la posición de las ranuras de microcinta creadas en el parche radiante de una antena de microcinta. El trabajo presentó la simulación mediante el software de optimización automática CST Studio, de una antena para captura de energía de radiofrecuencia empleando el substrato ARLON AD450 con constante dieléctrica de 4.5, pérdidas tangenciales de 0.035 y espesor de 3 mm. En este diseño se aplicaron varias ranuras hasta formar una espira cuadrada. Los resultados obtenidos evidenciaron que al aumentar el espesor del sustrato que separa el plano de tierra del parche radiante, se produce una disminución en las pérdidas de retorno del parámetro y al mismo tiempo se da un aumento en la ganancia de la antena. La creación de ranuras, el grosor y la ubicación de estas en el parche radiante producen un desplazamiento en la frecuencia de resonancia. Asimismo, el arreglo presentado permite frecuencias de resonancia alrededor de 1.6 GHz, 2.38 GHz, 3.38 GHz y 4.16 GHz, con una ganancia entre 2.48 dB y 7.66 dB. Este diseño de antena permitió mejoras en ganancia y en el patrón de radiación. La creación de ranuras en el parche radiante modificó la distribución de corriente de superficie de la antena y generó nuevas frecuencias de resonancia. Los espacios de aire creados entre el cobre y el substrato mejoraron el rendimiento de la antena, del mismo modo que el espacio ejercido por el substrato entre el plano de tierra y el parche radiante disminuyeron las pérdidas de ganancia en la antena debido a la reducción del cobre cuando se realizan estas ranuras. La antena propuesta presenta un comportamiento multibanda inmediatamente se agregan ranuras en el parche. La evaluación de substratos y estructuras son útiles para el desarrollo de antenas de microcinta integradas para sistemas de recolección de energía de radiofrecuencia.