bluuebunny/crossref_metadata_2025_split huggingface dataset:
Further Studies of the Third Instar Larval Cuticle of Calliphora erythrocephala
Authors: Wolfe L. S. 
Published: April 2021

ABSTRACT
The penetration and reduction of ammoniacal silver nitrate solution in the epicuticle of the larva of Calliphora was studied. The epicuticle of the third instar larva is more permeable over the muscle insertions and cuticular sense organs. This finding is related to their development at the previous moult.
A surface layer of orientated wax is not present. Proteinaceous and fatty materials from the feeding medium modify the properties of the cuticle surface. Chloroformmethanol extracts a soft light brown acidic lipide from the protein of the epicuticle after contaminants from the medium are removed.
The water loss from larvae and puparia of different ages and after various treatments was studied. Young puparia recover from abrasion but larvae do not. An hypothesis that waxy substances are liberated on to the surface of the puparium during hardening and darkening of the cuticle is presented and discussed.
The pore canals penetrate the endocuticle until they are cut off from the epidermis by the development of the prepupal cuticle just after the puparial contraction. An inner endocuticle in which pore canals were absent was not found. The structure of the pore canals as shown by phase contrast examination is discussed. The pore canals are three times more concentrated in the lateral regions than in the dorsal or ventral regions.
The oenocytes go through a secretory cycle during puparium formation similar to that occurring before moulting of the larva.
Staining Differences in Cell Nuclei
Authors: Lison Lucien 
Published: April 2021

ABSTRACT
If the parenchymal cells of the liver of the rat, or certain other cells, are stained with a modified Mallory stain or with iron haematoxylin, the nuclei are stained in two different ways. This effect may be observed after various fixatives.
Direct microscopical observation shows that when part of a nucleus is cut away hy the microtome-knife, the part of it remaining in the section stains differently from an intact nucleus. The probability of a nucleus being wholly or only partly contained in a section of a particular thickness can be calculated.
Counts made in sections of various thicknesses show that the proportion of nuclei stained in the different ways is consistent with the calculated probability.
It is suggested that the nuclear membrane in the fixed state presents a relatively low permeability.
The Structure and Connexions of the Corpora Pedunculata in Bees and Ants
Authors: Vowles D. M. 
Published: April 2021

ABSTRACT
A method is described of using high frequency radio waves to produce localized and precisely controlled burns. The technique is employed to damage the cells of the corpora pedunculata in bees and ants, and to follow the subsequent degeneration in these lobes. The corpora pedunculata on each side of the brain are composed of four lobes: two calyces, an α lobe and a β lobe. Each fibre originates from a cell in the calyx, and has three branches, one to the calyx itself, one to the β lobe, and one to the β lobe. The arrangement of the tracts in these lobes is described. The calyces and the α lobe both receive tracts from all the sensory centres of the brain, while the β lobe sends tracts to the motor regions. The detailed connexions of these tracts are described. It is suggested that in the functioning of the corpora pedunculata the excitations from the calyx and the α lobe will interact, and that the excitation passing away down the β lobe is the result of this interaction.
Saving more lives and limbs: applying a cardiac rehabilitation model of structured exercise to symptomatic peripheral arterial disease
Authors: Matthews Susan , Fox Martin , Coy Sarah , Whittaker Jane , Brough Gail , Yasin Mohammad , Whittle Susan 
Published: April 2021

Background/Aims Peripheral arterial disease is common among those aged 60 years or above and can cause debilitating intermittent claudication. This impacts quality of life and is a marker for increased morbidity and mortality, mainly from cardiovascular disease. Access to recommended exercise programmes for people with symptomatic peripheral arterial disease is poor in most areas of the UK. This study aimed to evaluate the benefits of expanding an established cardiac rehabilitation service to accommodate supervised exercise for people with peripheral arterial disease Methods The study evaluated 11 participants peripheral arterial disease and intermittent claudication who were referred by the Manchester leg circulation service. Participants underwent the programme involving eight weekly 1.5 hour sessions of supervised exercise and cardiovascular education with support, reassurance and motivation. The participants' blood pressure, walking impairment, quality of life, anxiety and depression were monitored and reviewed. Results Overall, the participants' walking distance, intermittent claudication, quality of life and blood pressure had improved. The participants' overall satisfaction with the programme was excellent. The programme also demonstrated clinical and cost-effectiveness. Conclusions A structured, supervised exercise programme can have considerable benefits for people with peripheral arterial disease, improving their symptoms and quality of life. It may also help to reduce the morbidity and mortality risks associated with inactivity in this patient group.
Advance care planning for patients with COVID-19: a communication guide
Authors: Palipane Natasha , Ponnampalampillai Abi , Gupta Srirupa 
Published: April 2021

In view of the high morbidity and mortality associated with COVID-19, early and honest conversations with patients about goals of care are vital. Advance care planning in its traditional manner may be difficult to achieve given the unpredictability of the disease trajectory. Despite this, it is crucial that patients' care wishes are explored as this will help prevent inappropriate admissions to hospital and to critical care, improve symptom control and advocate for patient choice. This article provides practical tips on how to translate decisions around treatment escalation plans into conversations, both face-to-face and over the phone, in a sensitive and compassionate manner.Care planning conversations for patients with COVID-19 should be individualised and actively involve the patient. Focusing on goals of care rather than ceilings of treatment can help to alleviate anxiety around these conversations and will remind patients that their care will never cease. Using a framework such as the ‘SPIKES’ mnemonic can help to structure this conversation. Verbally conveying empathy will be key, particularly when wearing personal protective equipment or speaking to relatives over the phone. It is also important to make time to recognise your own emotions during and/or after these conversations.
Day-case open reduction for developmental dysplasia of the hip
Authors: Flatman Michael , Barkham Ben H. , Ben David Eyal , Yeo Andrea , Norman Joanne , Gelfer Yael 
Published: April 2021

Aims Open reduction in developmental dysplasia of the hip (DDH) is regularly performed despite screening programmes, due to failure of treatment or late presentation. A protocol for open reduction of DDH has been refined through collaboration between surgical, anaesthetic, and nursing teams to allow same day discharge. The objective of this study was to determine the safety and feasibility of performing open reduction of DDH as a day case. Methods A prospectively collected departmental database was visited. All consecutive surgical cases of DDH between June 2015 and March 2020 were collected. Closed reductions, bilateral cases, cases requiring corrective osteotomy, and children with comorbidities were excluded. Data collected included demographics, safety outcome measures (blood loss, complications, readmission, reduction confirmation), and feasibility for discharge according to the Face Legs Activity Cry Consolidability (FLACC) pain scale. A satisfaction questionnaire was filled by the carers. Descriptive statistics were used for analysis. Results Out of 168 consecutive DDH cases, 16 patients fit the inclusion criteria (age range 10 to 26 months, 13 female). Intraoperative blood loss ranged from "minimal" to 120 ml, and there were no complications or readmissions. The FLACC score was 0 for all patients. The carers satisfaction questionnaire expressed high satisfaction from the experience with adequate information and support provided. Conclusion Open reduction in DDH, without corrective osteotomy, is safe and feasible to be managed as a day case procedure. It requires a clear treatment pathway, analgesia, sufficient counselling, and communication with carers. It is even more important during the COVID-19 pandemic when reduced length of hospital stay is likely to be safer for both patient and their parents. Cite this article: Bone Joint Open 2021;2(4):271–277.
Actual state of “triple therapy” for heart failure patients in eight regions of Japan: An analysis of a nationwide medical claims database
Authors: Abe Daisuke , Inomata Takayuki 
Published: April 2021

Background
This study aimed to collect data on “triple therapy” for heart failure (HF) with angiotensin-converting enzyme inhibitors (or receptor blockers), β-blockers, and mineralocorticoid receptor antagonists in all eight regions of Japan and clarify the reason for the selection of this therapeutic approach.

Methods and results
We used data from April 2017 to March 2018 from the Medical Data Vision database (380 facilities) to analyze factors impacting triple therapy for HF. Among patients who were hospitalized for HF during the study period, 51,933 patients met the inclusion criteria and underwent further analyses. A reference value of 20.45% from Kanto was used to compare the eight Japanese regions.
From the patient cohort, 10,006 (19.27%) patients receiving triple therapy were identified.
The highest and lowest rates of triple therapy were in Chugoku (21.90%) and Shikoku (14.27%), respectively, suggesting regional differences in the use of triple therapy at discharge for patients with HF (P < 0.001). Regression analysis revealed a decrease in the administration of triple therapy for patients with chronic kidney disease (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.43–0.48]; P < 0.001), those aged 75 years and older (OR, 0.46, 95% CI: 0.44–0.49; P < 0.001), those from Shikoku (OR, 0.69; 95% CI, 0.60–0.80; P < 0.001), those with chronic obstructive pulmonary disease (OR, 0.75; 95% CI, 0.68–0.84; P < 0.001), those with anemia (OR, 0.78; 95% CI, 0.62–0.98; P = 0.034), and those from Tohoku (OR, 0.83; 95% CI, 0.75–0.92; P < 0.001).

Conclusions
Future efforts to rectify the regional variance in drug therapy conforming to the guidelines for the treatment of acute and chronic HF will help to extend the healthy lifespans of patients with HF. Further clarification is required to determine instances where triple therapy should be avoided based on patient factors, and appropriate countermeasures should be identified.
Willingness to vaccinate against COVID-19 among Bangladeshi adults: Understanding the strategies to optimize vaccination coverage
Authors: Abedin Minhazul , Islam Mohammad Aminul , Rahman Farah Naz , Reza Hasan Mahmud , Hossain Mohammad Zakir , Hossain Mohammad Anwar , Arefin Adittya , Hossain Ahmed 
Published: April 2021

BackgroundAlthough the approved COVID-19 vaccine has been shown to be safe and effective, mass vaccination in Bangladeshi people remains a challenge. As a vaccination effort, the study provided an empirical evidence on willingness to vaccinate by sociodemographic, clinical and regional differences in Bangladeshi adults.MethodsThis cross-sectional analysis from a household survey of 3646 adults aged 18 years or older was conducted in 8 districts of Bangladesh, from December 12, 2020, to January 7, 2021. Multinomial regression examined the impact of socio-demographic, clinical and healthcare-releated factors on hesitancy and reluctance of vaccination for COVID-19.ResultsOf the 3646 respondents (2212 men [60.7%]; mean [sd] age, 37.4 [13.9] years), 74.6% reported their willingness to vaccinate against COVID-19 when a safe and effective vaccine is available without a fee, while 8.5% were reluctant to vaccinate. With a minimum fee, 46.5% of the respondents showed intent to vaccinate. Among the respondents, 16.8% reported adequate adherence to health safety regulations, and 35.5% reported high confidence in the country’s healthcare system. The COVID-19 vaccine refusal was significantly high in elderly, rural, semi-urban, and slum communities, farmers, day-laborers, homemakers, low-educated group, and those who had low confidence in the country’s healthcare system. Also, the prevalence of vaccine hesitancy was high in the elderly population, low-educated group, day-laborers, people with chronic diseases, and people with low confidence in the country’s healthcare system.ConclusionA high prevalence of vaccine refusal and hesitancy was observed in rural people and slum dwellers in Bangladesh. The rural community and slum dwellers had a low literacy level, low adherence to health safety regulations and low confidence in healthcare system. The ongoing app-based registration for vaccination increased hesitancy and reluctancy in low-educated group. For rural, semi-urban, and slum people, outreach centers for vaccination can be established to ensure the vaccine’s nearby availability and limit associated travel costs. In rural areas, community health workers, valued community-leaders, and non-governmental organizations can be utilized to motivate and educate people for vaccination against COVID-19. Further, emphasis should be given to the elderly and diseased people with tailored health messages and assurance from healthcare professionals. The media may play a responsible role with the vaccine education program and eliminate the social stigma about the vaccination. Finally, vaccination should be continued without a fee and thus Bangladesh’s COVID vaccination program can become a model for other low and middle-income countries.
Characteristics of physicians working at geriatric health service facilities in Japan, 1996–2016
Authors: Ishikawa Masatoshi , Iwagami Masao , Tamiya Nanako 
Published: April 2021

Background
In Japan, which has the most rapidly aging population worldwide, the number of geriatric health service facilities (GHSFs) has been increasing. GHSF physicians play significant roles in integrated care for the elderly. However, little is known about the temporal trends of physicians working in GHSFs.

Objectives
We aim to examine temporal trends in the characteristics of GHSF physicians and identify physician factors associated with starting work at GHSFs.

Design
Cohort study.

Setting and participants
Physicians responding to biennial national physician census surveys conducted by the Ministry of Health, Labour and Welfare of Japan from 1996 to 2016. The response rate was approximately 90%.

Methods
We estimated temporal trends in the number, proportion, and characteristics of GHSF physicians. A multivariable logistic regression analysis identified physician factors associated with starting work at GHSFs 10 years after 1996–2006 and 2006–2016 among physicians not working in GHSFs at baseline (1996 and 2006).

Results
GHSF physicians rapidly increased in the first decade from 1,127 (0.47%) in 1996 to 2,891 (1.04%) in 2006; this trend then slowed and was almost proportional to that of all physicians, reaching 3,345 (1.05%) in 2016. GHSF physicians aged ≥65 years increased from 61.2% in 1996 to 68.5% in 2016, while those aged <40 years decreased from 13.8% to 1.9%. The sex ratio (male vs. female physicians) increased from 5.7 in 1996 to 6.4 in 2016. Physician factors associated with starting to work at GHSFs included older age, female sex, rural area, working at hospitals, and majored in internal medicine and surgery specialties.

Conclusions
The proportion of GHSF physicians among all physicians has stagnated, and GHSF physicians are aging. Facilitating the transition of younger physicians from clinical practice in hospitals to GHSFs will increase the number of GHSF physicians and improve the quality of care in GHSFs.
COVID-19 vaccine hesitancy in perinatal women: a cross sectional survey
Authors: Mohan Suruchi , Reagu Shuja , Lindow Stephen , Alabdulla Majid 
Published: April 2021

Abstract

Objectives
To explore attitudes to COVID-19 vaccination among perinatal women.

Methods
A nationwide online, cross-sectional survey was conducted in Qatar from 15th October 2020 to 15th November 2020 with voluntary participation open to all adult residents. Of the respondents, the population group for this study comprised the 341 pregnant and breastfeeding participants. The survey utilized a composite questionnaire incorporating a validated instrument to measure vaccine attitudes. The responses were recorded and analysed with statistical analysis being performed with SPSS software. Outcome measures included intentions towards vaccination and potential factors influencing vaccine hesitancy (contextual factors, vaccine specific concerns and group/individual influences).

Results
Perinatal women exhibited a vaccine hesitancy rate of 25% towards COVID-19 immunisation. The main concerns of the group were of infection risks and main factor determining vaccine hesitancy was of vaccine specific safety concerns. Previous vaccine “acceptors” showed vaccine hesitancy to COVID-19 immunisation. A third of the group cited non availability of the vaccine as a concern.

Conclusions
COVID-19 vaccine trials amongst pregnant and lactating women have lagged behind those for general populations and this has compounded concerns around safety in this special group. Perinatal women constitute a vulnerable group and play an important role in vaccination of wider family members. This study highlights the need for trials and data for COVID-19 vaccine in this group to be able to achieve appreciable numbers needed for herd immunity and ultimately control of the pandemic.
Recent advances on the fabrication methods of nanocomposite yarn-based strain sensor
Authors: Tang Xiaoning , Cheng Deshan , Ran Jianhua , Li Daiqi , He Chengen , Bi Shuguang , Cai Guangming , Wang Xin 
Published: April 2021

Abstract
Yarn-based strain sensor is an emerging candidate for the fabrication of wearable electronic devices. The intrinsic properties of yarn, such as excellent lightweight, flexibility, stitchability, and especially its highly stretchable performance, stand out the yarn-based strain sensor from conventional rigid sensors in detection of human body motions. Recent advances in conductive materials and fabrication methods of yarn-based strain sensors are well reviewed and discussed in this work. Coating techniques including dip-coating, layer by layer assemble, and chemical deposition for deposition of conductive layer on elastic filament were first introduced, and fabrication technology to incorporate conductive components into elastic matrix via melt extrusion or wet spinning was reviewed afterwards. Especially, the recent advances of core–sheath/wrapping yarn strain sensor as-fabricated by traditional spinning technique were well summarized. Finally, promising perspectives and challenges together with key points in the development of yarn strain sensors were presented for future endeavor.
Bicyclic and tricyclic phosphanes with p-block substituents
Authors: Bresien Jonas , Faust Kirill , Schulz Axel 
Published: April 2021

Abstract
This review summarises the experimental and structural knowledge on polycyclic phosphanes, with a focus on bicyclic and tricyclic phosphanes, as they have not only been the most studied in the last 25 years, but also show the greatest diversity in terms of constitutional isomerism and structural motifs. Moreover, only polycyclic phosphanes that have p-block substituents at all free valences are discussed.
Geographical distribution, habitats and modern state of Carlina cirsioides (Asteraceae) populations
Authors: Melnyk V. I. , Kovalchuk I. O. , Dovhopola L. I. , Shapran Y. P. 
Published: April 2021

The study of the current state and habitats of rare and threatened species of plants is a relevant task of ecological research. The paper presents the results of the study of systematic position, habitats and modern state of populations of a rare species included in the Red DataBook of Ukraine Carlina cirsioides Klokov (=C. acaulis L.). Carlina cirsioides is well-known to European phytosozologists as an endemic and relic species of the Flora of Ukraine. At the same time, the species independence of this taxon is not recognized by the authors of monographs on the Carlina genus and by the authors of “Flora Europaea”. Comparative morphological, chorological and ecological-coenotic analyses do not give sufficient reasons to consider C. cirsioides described by Klokov as a separate species, endemic and relic species of the Flora of Ukraine. According to the morphological traits, the specimens from the lowland part of Ukraine belong to the C. acaulis caulescens subspecies, which is distributed mostly in the lowlaand regions of Europe. Ecological-coenotic conditions of habitats of C. acaulis in the plains of Ukraine are different from those in the mountain regions and are close to the plains habitats of this species in Central Europe. Steppe communities of class Festuco-Brometea, of which C. acaulis is component in the plains part of Ukraine, are close to xerothermic herbaceous communities of Central Europe; forest communities of Erico-Pinetea with C. cirsioides in Ukrainian Polissia and the North-East Poland are very сlose by floristic composition. The removal of separate species status of the plains populations of C. acaulis near the eastern border of the range does not at all downplay its sozological significance. Taking into account the low number of C. acaulis in the Volhynian-Podolian Upland and in the Polesian Lowland, all localities of this species in the lowland part of the range in Ukraine must be taken under protection in situ.
Allocation of the diet of the Argentine Islands’ inshore ichthyofauna
Authors: Zinkovskyi A. V. , Dykyy I. V. , Trokhymets V. M. 
Published: April 2021

Fish diets are important indicators of ecosystem change. This aspect of the ichthyofauna of the coast of the Argentine Islands has been insufficiently studied in comparison with other regions. This article presents the results of comparison of dietary and somatic parameters of the dominant species Notothenia coriiceps depending on the point, depth and season of catch. The sample was collected between February 2006 and February 2007. In the year of study, N. coriiceps, Trematomus bernacchii, Chaenocephalus aceratus (common species), Harpagifer antarcticus and Pagothenia borchgrevinki (rare species in this region) were caught. The average fish size in this region does not differ from other places in the Southern Ocean. In Cornice Channel and Stella Creek, N. coriiceps was smaller than at other points due to the narrowness and shallow depth of these places. In winter, large individuals apparently migrated from the coast. The diet of N. coriiceps consisted mainly of crustaceans and seaweeds, with a small number of mollusks (especially limpets), which are common. The number of fish in the diet of N. coriiceps is relatively low for this region. Access to food was relatively the same at different points and depths of the catch. The lowest amount of food was in the fall, the highest amount of food was in the spring and summer. The condition and hepatosomatic index also did not change depending on the point and depth of the catch, but they were low in spring and high in summer. Perhaps this is due to the low energy value of food, which is not compensated by the amount. It is necessary to conduct studies of the diet of N. coriiceps in other years to clarify the specificity of fish in the diet and phenological changes in somatic parameters. Similar studies are needed for other species in the region if catches are sufficient to collect a representative sample.