bluuebunny/crossref_metadata_2025_split huggingface dataset:
National Excess Mortality from Sub-National data: Method and Application for Argentina
Authors: Karlinsky Ariel 
Published: August 2021

AbstractCurrently, many countries have not yet reported 2020 or 2021 mortality data to allow an estimate of excess mortality during the COVID-19 pandemic. However, some countries have sub-national mortality data, at the state, province or city level. I present a simple method to allow estimation of national level mortality and excess mortality from sub-national data, using the case of Argentina and projecting excess mortality up to August 2021.
EVALUATION OF STED SUPER-RESOLUTION IMAGE QUALITY BY IMAGE CORRELATION SPECTROSCOPY (QuICS)
Authors: Cerutti Elena , D’Amico Morgana , Cainero Isotta , Dellino Gaetano Ivan , Faretta Mario , Vicidomini Giuseppe , Pelicci Pier Giuseppe , Bianchini Paolo , Diaspro Alberto , Lanzanò Luca 
Published: August 2021

ABSTRACTQuantifying the imaging performances in an unbiased way is of outmost importance in super-resolution microscopy. Here, we describe an algorithm based on image correlation spectroscopy (ICS) that can be used to assess the quality of super-resolution images. The algorithm is based on the calculation of an autocorrelation function and provides three different parameters: the width of the autocorrelation function, related to the spatial resolution; the brightness, related to the image contrast; the relative noise variance, related to the signal-to-noise ratio of the image. We use this algorithm to evaluate the quality of stimulated emission depletion (STED) images of DNA replication foci in U937 cells acquired under different imaging conditions. Increasing the STED power improves the resolution but may reduce the image contrast. Increasing the number of line averages improves the signal-to-noise ratio but facilitates the onset of photobleaching and subsequent reduction of the image contrast. Finally, we evaluate the performances of two different separation of photons by lifetime tuning (SPLIT) approaches: the method of tunable STED power and the commercially available Leica Tau-STED. We find that SPLIT provides an efficient way to improve the resolution and contrast in STED microscopy.
Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2
Authors: Singh Ranjan K. , Soliman Ahmed , Guaitoli Giambattista , Störmer Eliza , von Zweydorf Felix , Maso Thomas Dal , Van Rillaer Laura , Schmidt Sven H. , Chatterjee Deep , Pardon Els , Knapp Stefan , Kennedy Eileen J. , Steyaert Jan , Herberg Friedrich W. , Kortholt Arjan , Gloeckner Christian J. , Versées Wim 
Published: August 2021

AbstractMutations in the gene coding for Leucine-Rich Repeat Kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson’s disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large multi-domain protein, including a GTPase as well as a Ser/Thr protein kinase domain. Common disease-causing mutations increase LRRK2 kinase activity, presenting LRRK2 as an attractive target for inhibitory drug design. Currently, drug development has mainly focused on ATP-competitive kinase inhibitors. Here, we report the identification and characterization of a variety of Nanobodies that bind to different LRRK2 domains and inhibit or activate LRRK2 activity in cells and in vitro. Importantly, diverse groups of Nanobodies were identified that inhibit LRRK2 kinase activity through a mechanism that does not involve binding to the ATP pocket or even to the kinase domain. Moreover, while certain Nanobodies completely inhibit the LRRK2 kinase activity, we also identified Nanobodies that specifically inhibit the phosphorylation of Rab protein substrates. Finally, in contrast to current type-I kinase inhibitors, the studied kinase-inhibitory Nanobodies did not induce LRRK2 microtubule association. These comprehensively characterized Nanobodies represent versatile tools to study the LRRK2 function and mechanism, and can pave the way toward novel diagnostic and therapeutic strategies for PD.
Hybridization as practice: clinical engagement with performance metrics and accounting technologies in the English NHS
Authors: Begkos Christos , Antonopoulou Katerina 
Published: August 2021

PurposeThis study aims to investigate the hybridization practices that medical managers engage with to promote accounting and performance measurement in the hybrid setting of healthcare. In doing so, the authors explore how medical managers enact and become practitioners of hybridity.Design/methodology/approachThe authors adopt a practice lens to conceptualize hybridization as an emergent, situated practice and capture the micro-activities that medical managers engage with when they enact hybridity. The authors conducted semi-structured interviews with medical managers, business managers and coding professionals and collected documents at an English National Health Service (NHS) hospital over the course of five years.FindingsThe findings accentuate two emergent practices through which medical managers instill hybridity to individuals who are hesitant or resistant to hybridization. Medical managers engage in equivocalizing and de-stigmatizing practices to broaden the understandings, further diversify or reconcile the teleologies of clinicians in non-managerial roles. In doing so, the authors signal the merits of accounting in improving care outcomes and remove the stigma associated to clinical engagement with costs.Originality/valueThe study contributes to hybridization and practice theory literature via capturing how hybridity is enacted in practice in a healthcare setting. As medical managers engage with and promote accounting information and performance measurement technologies in their practice environment, they transcend professional boundaries and hybridize the professional spaces that surround them.
A novel retractable landing gear of a light amphibious airplane design, synthesis, analysis, and implementation
Authors: Chinvorarat Sinchai , Vallikul Pumyos 
Published: August 2021

Purpose
The purpose of this paper is to present a novel retractable main landing gear for a light amphibious airplane, while the design, synthesis and analysis are given in details for constructing the main landing gear.

Design/methodology/approach
The constraint three-position synthesis has given the correct path of all linkages that suitably fit the landing gear into the compartment. The additional lock-link is introduced into the design to ensure the securement of the mechanism while landing. Having the telescopic gas-oil shock strut as a core element to absorb the impact load, it enhances the ability and efficiency to withstand higher impact than others type of light amphibious airplane.

Findings
By kinematics bifurcation analysis, the optimized value of the unlock spring stiffness at 90 N/m can be found to tremendously reduce the extended-retracted linear actuator force from 500 N to 150 N at the beginning of the retraction sequence. This could limit the size and weight of the landing gear actuator of the light amphibious airplane.

Practical implications
The drop test of the landing gear to comply with the ASTM f-2245 (Standard Specification for Design and Performance of a Light Sport Airplane) reveals that the novel landing gear can withstand the impact load at the drop height determined by the standard. The maximum impact loading 4.8 G occurs at the drop height of 300 mm, and there is no sign of any detrimental or failure of the landing gear or the structure of the light amphibious airplane. The impact settling time response reaches the 2% of steady-state value in approximately 1.2 s that ensure the safety and stability of the amphibious airplane if it subjects to an accidentally hard landing.

Originality/value
This paper presents unique applications of a retractable main landing gear of a light amphibious airplane. The proposed landing gear functions properly and complies with the drop test standard, ensuring the safety and reliability of the airplane and exploiting the airworthiness certification process.
The effect of wavy surface on boundary layer instabilities of an airfoil
Authors: Rarata Zbigniew 
Published: August 2021

Purpose
The purpose of this paper is to investigate airfoil’s tonal noise reduction mechanism when deploying surface irregularities, such as surface waviness by means of spatial stability analyses.

Design/methodology/approach
Flow field calculations over smooth and wavy-surface NACA 0012 airfoils at 2° angle of attack and at Reynolds number of 200,000 are performed using the large eddy simulation (LES) approach. Three geometrical configurations are considered: a smooth NACA 0012 airfoil, wavy surface on the suction side (SS) and wavy surface on the pressure side (PS). The spatial stability analyses using the LES-generated flow fields are conducted and validated against the Orr-Sommerfeld stability analysis for the smooth airfoil configuration.

Findings
The spatial stability analyses show that inclusion of the wavy-type modification on the SS of the airfoil does not lead to altering of the acoustic feedback loop mechanism, with respect to the mechanism observed for the smooth airfoil configuration. In contrast, applying the surface modifications to the airfoil PS leads to a significant reduction of the amplification range of disturbances in the vicinity of the trailing edge for the frequency of the acoustic feedback loop mechanism.

Practical implications
The spatial analyses using, for example, LES-generated flow fields can be widely used to determine acoustic sources and associated distributions of amplifications for a wide range of applications in the aeroacoustics.

Originality/value
The spatial stability analysis approach based on flow fields computed a priori using the LES method has been introduced, validated and used to determine behaviour of the acoustic feedback loop when accurate reconstruction of geometry effects is required.
Factors affecting adoption of digital payments by semi-rural Indian women: extension of UTAUT-2 with self-determination theory and perceived credibility
Authors: Manrai Rishi , Goel Utkarsh , Yadav Prashant Dev 
Published: August 2021

PurposeThe aim of this research is to investigate the factors influencing the adoption of digital payments by the semi-rural women in India.Design/methodology/approachThe study extended the factors of unified theory of acceptance and use of technology UTAUT-2, with perceived credibility and self-determination theory to understand the use behaviour of the rural Indian women. The study checked the mediating role of some constructs besides testing the direct relationship. The study was conducted in the rural parts of the adjoining areas of Delhi, where the women from different states, education and financial background live. The research model was empirically tested on 568 respondents using structural equation modelling (SEM) technique.FindingsThe research model was able to explain 72.6% variance in the user behaviour variable. Effort expectancy, habit, facilitating conditions as well as perceived competence emerged out to be significant determinants of use behaviour. Besides these direct relationships, two constructs, habit as well as facilitating conditions were found to partially mediate the relationship between behavioural intention and behaviour.Originality/valueThis study provides some very critical clues for the companies providing digital payment services, by highlighting the significant factors explaining the technology adoption by semi-rural women. The companies must devise suitable marketing strategies to inculcate trust in mind of perspective customers towards their companies as well as the service provided by them. The role of simple digital platform, that is easy to learn and use, is also an important element in determining the technology adoption.
Street food handlers' food safety knowledge, attitudes and self-reported practices and consumers' perceptions about street food vending in Maseru, Lesotho
Authors: Letuka Ponts'o , Nkhebenyane Jane , Thekisoe Oriel 
Published: August 2021

PurposeFood safety knowledge and hygienic practices by food handlers play an important role in the prevention of contamination of food prepared.Design/methodology/approachThis descriptive survey was conducted in Maseru around the taxi ranks amongst 48 food handlers and 93 consumers using a semi-structured questionnaire for assessing food handler knowledge, attitudes and practices, open-ended questionnaire for obtaining consumer perceptions and observation checklist.FindingsMajority of the food handlers were females (60%) and males constituted only (40%). The mean age was 35.5 ± 10.3 and 28.2 ± 9.9 respectively for street vendors and consumers. There was a statistically significant difference in knowledge among the trained and untrained vendors (p = 0040). On average the vendor population that participated in this study was considered to have poor knowledge (scores < 50%) of food safety since they scored 49% ± 11, while 84% of the respondents were considered to have positive attitudes towards food safety. Only 6% of the consumers reported that they never buy street vended foods mainly due to the hygiene issues. The observation checklist showed that the vendors operated under unhygienic conditions and that there was scarcity of clean water supply and hand washing facilities.Originality/valueThis study provides knowledge that was previously unknown about food vending in Lesotho. It has significantly added to the body of knowledge on food safety in Lesotho which can be used to modify policies and structure food safety training for people involved in the informal trade.
A systematic review of faculty research repositories at higher education institutions
Authors: Zibani Patiswa , Rajkoomar Mogiveny , Naicker Nalindren 
Published: August 2021

Purpose
This study aims to evaluate faculty research repositories used in higher education institutions, their different levels and functions with regard to research information management. This is revealed through the selected studies reviewed.

Design/methodology/approach
A systematic literature search of journal article studies on research repositories in higher education institutions was carried out on several databases, namely, Ebscohost, Emerald Insight, Science Direct, Sage, Google Scholar, SA e-Publications and citation databases such as Scopus and Web of Science. The systematic review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses guidelines. The time frame for the analysis was 2015 to 2021.

Findings
The findings are presented on the motives for developing faculty research repositories the services provided and benefits derived from faculty research repositories and what is the utilization of faculty research repositories.

Originality/value
The results show that the development of research repositories at the faculty level enhances sharing, analysis, evaluation and preservation of scholarly research produced.
Developing mobility power tactics and strategies: the experiences of Central Eastern European workers in Scotland
Authors: Baxter-Reid Hazel 
Published: August 2021

PurposeThe purpose of this article is to examine the tactics and strategies utilised by Central Eastern European (CEE) migrant workers as they strive to develop their mobility power within the employment relationship and outside of the workplace.Design/methodology/approachData is drawn from three qualitative organisational case studies. In total 70 interviews with migrant workers, managers and HR staff were undertaken. There were also nine focus groups with migrant workers across the case studies.FindingsDeveloping mobility power is not straightforward, particularly in the context of hard HRM strategies. The majority of CEE workers across the case studies viewed the employment relationship as temporary; however, people found it difficult to develop the mobility power necessary to leave and move to a better job. This can be attributed to a combination of people's individual subjective factors and employment in occupations with limited structural and associational power.Originality/valueThis article engages with debates concerning the agency of migrant workers. Existing studies have focused upon the way in which migrant workers utilise mobility power to leave unfavourable employers. However, this article builds upon current debates by examining how migrant workers develop their mobility power. There is also consideration of the individual and collective dimensions of power.
Does family matter? The moderating role of family involvement on the relationship between CSR and firm performance
Authors: Yeon Jihwan , Lin Michael S. , Lee Seoki , Sharma Amit 
Published: August 2021

Purpose
The purpose of this study is to investigate the moderating role of family involvement on the corporate social responsibility (CSR)-firm performance (FP) relationship in the US hospitality industry. Building on agency theory, this study examines how family ownership, management and board control influence the relationship between CSR and FP.

Design/methodology/approach
To examine the moderating effect of family ownership, family management and family board control, this study adopts the two-way fixed-effects model and performs a panel regression analysis with robust standard errors. The sample period spans 1994–2018 and 565 firm-year observations are included.

Findings
This study finds that the impact of CSR on FP is positively moderated by the extent of a firm’s family member involvement. In specific, all three aspects of corporate governance (i.e. ownership, management and board control) positively moderate the relationship between CSR and FP.

Research limitations/implications
Findings of this study yield several recommendations for hospitality managers, including shaping strategic decisions for implementing CSR, by providing a unique perspective that the involvement of founding family members can be helpful in enhancing firm value through CSR activities.

Originality/value
This study sheds light on the further understanding of the CSR-FP link in the hospitality literature. In addition, this study provides practical guidelines for hospitality firms in the context of CSR by revealing possible advantages of strengthened founding family involvement.
Balancing between stability and change in Agile teams
Authors: Lindskog Carin , Netz Johan 
Published: August 2021

PurposeThis study aims to create a better understanding of how practitioners implement and work Agile while balancing the tensions arising between stability and change.Design/methodology/approachA grounded theory approach was used to explore what happens in practice when software development teams implement and work Agile. The empirical data consists of twenty semi-structured interviews with practitioners working in fourteen different organizations and in six different Agile roles.FindingsAs a result, a substantive theory was presented of continuously balancing between stability and change in Agile teams. In addition, the study also proposes three guidelines that can help organizations about to change their way of working to Agile.Research limitations/implicationsThe inherent limitation of a grounded theory study is that a substantial theory can only explain the specific contexts explored in that study. Thus, this study's contribution is a substantial theory that needs to be further developed and improved.Practical implicationsThe proposed guidelines can help organizations about to change their way of working to Agile. They can also assist organizations in switching from “doing Agile” to “being Agile”, thus becoming more successful.Originality/valueThe new perspective that this study contributes is the fact that our discovered categories show that several inherent processes are ongoing at the same time in order to balance the need to have both stability and change.
Elucidating technology-based social entrepreneurs’ scale and scope perspectives: a study of environmental and organizational variables
Authors: Bhattacharyya Som Sekhar 
Published: August 2021

PurposeThe purpose of this paper was to ascertain how social entrepreneurs were required to recognize their new ventures’ scope and scale of operations. The firm boundary was based upon two dimensions, namely, the scope of the offering and its scale. The objective of this research was to ascertain the thinking regarding this of social entrepreneurs engaged through technology-based social entrepreneurship (TBSE).Design/methodology/approachThis study conducted an in-depth interview of 26 technology entrepreneurs engaged in social entrepreneurship ventures in India. The interview was carried out based upon a semi-structured open-ended questionnaire. This study undertook thematic and relational content analysis to develop a model of technology-based social entrepreneurs’ venture scoping and scaling.FindingsThis study found that the antecedent variables were the level of support perceived by social entrepreneur from government and at the industry level. Furthermore, the variables’ entrepreneurial and market orientation of social entrepreneurs were found to be the independent variables. These four variables in turn determined the explorative and exploitative horizon of the technology-based social entrepreneurs. Finally, an interplay of these variables ascertained the perspectives of social entrepreneurs engaged in TBSE regarding the notion of their firm’s scope and scale.Research limitations/implicationsThe theoretical insights developed in this research study provided an integrated theoretical perspective accommodating both environmental perspectives (industry support and government support) and organizational perspectives (entrepreneurial and market aspects). This was in context of TBSE.Practical implicationsThe insights from this research study could provide a robust and comprehensive understanding to social entrepreneurs regarding the strategic thinking towards scale and scope for a technology-based social venture.Originality/valueTo the best of the author’s knowledge, this study was one of the first theoretical works in TBSE towards scaling versus scoping perspectives.
Integrated co-creation process with multiple stakeholders in innovation networks
Authors: Takahashi Sergio , Takahashi Vania Passarini 
Published: August 2021

PurposeThe purpose of this paper is to study the organizational processes in co-creation with multiple stakeholders within the scope of innovation networks. It consists of analyzing the necessary adaptation of organizational processes and to structure a proposal of an integrated process.Design/methodology/approachThis paper is a review article, an analysis of relevant articles in the areas of co-creation with multiple stakeholders, innovation networks, dynamic capabilities and organizational aspects linked to network organization which reflect on the main differences by relating them to the relevant literature.FindingsIdentification of related processes: Innovation development, knowledge integration/sharing, Co-evolution, Value Co-creation, Value Capture, Stakeholders capabilities, and elements of an integrated process in an innovation network.Originality/valueProposition of an integrated co-creation process with multiple stakeholders in an innovation network based on dynamic capabilities with the elements of literature and an analysis of the model variables. This process makes it possible, before reconfiguring the network itself, to create and to define the Project in an integrated manner. They also promote an evolution in the commitment, in the relationship and in the sharing of knowledge among the stakeholders and in the anticipation and evaluation by the stakeholders.