bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitators and barriers to clinical practice guideline-consistent supportive care at pediatric oncology institutions: a Children’s Oncology Group study
Authors: Sugalski Aaron J. , Lo Tammy , Beauchemin Melissa , Grimes Allison C. , Robinson Paula D. , Walsh Alexandra M. , Santesso Nancy , Dang Ha , Fisher Brian T. , Wrightson Andrea Rothfus , Yu Lolie C. , Sung Lillian , Dupuis L. Lee 
Published: September 2021

Abstract
Background
Clinical practice guideline (CPG)-consistent care improves patient outcomes, but CPG implementation is poor. Little is known about CPG implementation in pediatric oncology. This study aimed to understand supportive care CPG implementation facilitators and barriers at pediatric oncology National Cancer Institute (NCI) Community Oncology Research Program (NCORP) institutions.

Methods
Healthcare professionals at 26 pediatric, Children's Oncology Group-member, NCORP institutions were invited to participate in face-to-face focus groups. Serial focus groups were held until saturation of ideas was reached. Supportive care CPG implementation facilitators and barriers were solicited using nominal group technique (NGT), and implementation of specific supportive care CPG recommendations was discussed. Notes from each focus group were analyzed using a directed content analysis. The top five themes arising from an analysis of NGT items were identified, first from each focus group and then across all focus groups.

Results
Saturation of ideas was reached after seven focus groups involving 35 participants from 18 institutions. The top five facilitators of CPG implementation identified across all focus groups were organizational factors including charging teams with CPG implementation, individual factors including willingness to standardize care, user needs and values including mentorship, system factors including implementation structure, and implementation strategies including a basis in science. The top five barriers of CPG implementation identified were organizational factors including tolerance for inconsistencies, individual factors including lack of trust, system factors including administrative hurdles, user needs and values including lack of inclusivity, and professional including knowledge gaps.

Conclusions
Healthcare professionals at pediatric NCORP institutions believe that organizational factors are the most important determinants of supportive care CPG implementation. They believe that CPG-consistent supportive care is most likely to be delivered in organizations that prioritize evidence-based care, provide structure and resources to implement CPGs, and eliminate implementation barriers.

Trial registration
ClinicalTrials.gov Identifier: NCT02847130. Date of registration: July 28, 2016.
Can nasal nitric oxide be a biomarker to differentiate allergic and non-allergic rhinitis?
Authors: Kalpaklioglu A. F. , Baccioglu A. , Yalim S. A. 
Published: September 2021

Abstract
Background
Nasal nitric oxide (nNO), a noninvasive indicator for eosinophilic airway inflammation, has not been adequately studied in different types of rhinitis. The aim of this study was to compare nNO levels between allergic (AR) and non-allergic rhinitis (NAR). Patients were included based on their chronic nasal symptoms. Total nasal symptoms score (TNSS) were evaluated. nNO was measured transnasally with a flow of 5 ml/s from the nostril with an NO analyzer (NIOX MINO; Aerocrine, Sweden). Results were evaluated as parts per billion (ppb).

Results
Four hundred forty-three patients (277 F/166 M)—337 with AR (76%) and 106 with NAR (24%)—were assessed. Patients with AR had significantly higher TNSS, more severe disease, and longer duration of disease compared to NAR group. Allergic rhinitis had significantly higher nNO levels than NAR (370 ppb vs 290 ppb) (p = 0.001). Likewise, significant differences were observed in female gender, in patients with BMI ≥ 25 kg/m2 and those without sinusitis between the two groups. When nNO were further evaluated in comorbid asthma, patients with AR w/o asthma had the highest TNSS and had significantly higher nNO level (p < 0.001). NAR+A group, with the longest duration of rhinitis, was significantly older and had the lowest nNO level (p < 0.001).

Conclusions
This study showed that nNO levels were significantly higher in AR patients than NAR. Although there is no recommended standard threshold for nNO, this study confirmed the utility of nNO in differentiating AR and NAR in addition to its known fast and non-invasive advantages.
Disproportionate Negative Impact of the Radiation Oncology Alternative Payment Model on Rural Providers: A Cost Identification Analysis of Medicare Claims
Authors: Mantz Constantine A. , Thaker Nikhil G. , Pendyala Praveen , Hubbard Anne , Eichler Thomas J. , Shah Chirag , Orio Peter F. , Petereit Daniel G. 
Published: September 2021

PURPOSE: The Radiation Oncology Alternative Payment Model (APM) is a Medicare demonstration project that will test whether prospective bundled payments to a randomly selected group of physician practices, hospital outpatient departments, and freestanding radiation therapy centers reduce overall expenditures while preserving or enhancing the quality of care for beneficiaries. The Model follows a complicated pricing methodology that blends historical reimbursements for a defined set of services made to professional and technical providers to create a weighted payment average for each of 16 cancer types. These averages are then adjusted by various factors to determine APM payments specific to each participating provider. METHODS: This impact study segregates APM participants into rural and urban groups and analyzes the effect of the Radiation Oncology Alternative Payment Model on their fee-for-service reimbursements. RESULTS: The main findings of this study are (1) the greater net-negative revenue impact on rural facilities versus urban facilities that would have participated in the Model this year and (2) the relative lack of high-value treatment services (ie, stereotactic radiotherapy and brachytherapy) delivered by rural facilities that exacerbates their negative impact. CONCLUSION: As such, rural providers participating in the Model in its current form may face greater risk to their economic viability and greater difficulty in funding technology improvements necessary for the achievement of high-quality care compared with their urban counterparts.
Imagem e memória em um olhar estratégico sobre o legado de Jean-Michel Basquiat
Authors: Rainho Hélio Ricardo 
Published: September 2021

O artigo propõe uma reflexão sobre alguns aspectos possíveis do agenciamento do pintor Jean-Michel Basquiat sobre sua própria imagem em consonância com a narrativa de suas obras, dialogando com os escritos de Georges Didi-Huberman sobre a sobrevivência da imagem no tempo e de Michael Pollak sobre a questão da memória como uma forma de narrativa estabelecida a partir de um campo de disputa, construção e poder.
Clinical Re-evaluation on Bioequivalence and Relative Bioavailability of Micronized Progesterone Hard Capsule (Yimaxin) and Micronized Progesterone Soft Capsule (Utrogestan) under Vaginal and Oral Administration Routes
Authors: Wang Hanbi , Liu Meizhi , Chen Rui , Deng Chenyan 
Published: September 2021

Background and Objective: To clinically re-evaluate relative bioavailability and bioequivalence of micronized progesterone (hard capsule) Yimaxin and micronized progesterone (soft capsule) Utrogestan under vaginal and oral administration routes.
Methods: From December 2017 to June 2018, a total of 16 postmenopausal healthy women were recruited and received a total of four rounds of drug treatment with cross-over design, respectively Yimaxin and Utrogestan under vaginal and oral administration routes. Changes in the subjects’ hormone levels after medication were monitored and an endometrial biopsy after a course of treatment was performed in our hospital.
Result: The Geomeans of AUC0-t of Yimaxin and Utrogestan under vaginal administration route were 252.15 and 115.46, respectively, with a ratio of 2.19, and under oral administration route were 244.64 and 413.68, respectively, with a ratio of 0.59. The Geomeans of Cmax of Yimaxin and Utrogestan under vaginal administration route were 28.11 and 12.21, respectively, with a ratio of 2.30, and under oral administration route were 53.12 and 129.85, respectively, with a ratio of 0.41.
Conclusion: Yimaxin was not bioequivalent to Utrogestan. Yimaxin had higher exposure to the drug in vivo at the same dose when administered vaginally, and Utrogestan had higher exposure to the drug in vivo at the same dose when administered orally.
doi: https://doi.org/10.12669/pjms.37.7.3949
How to cite this:Wang H, Liu M, Chen R, Deng C. Clinical Re-evaluation on Bioequivalence and Relative Bioavailability of Micronized Progesterone Hard Capsule (Yimaxin) and Micronized Progesterone Soft Capsule (Utrogestan) under Vaginal and Oral Administration Routes. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.3949
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Value and Cost of Crop Minimum Support Price: Farmer and Consumer Welfare and Implementation Cost
Authors: Chintapalli Prashant , Tang Christopher S. 
Published: September 2021

In many developing countries, crop minimum support price (MSP) is a subsidy scheme to (i) improve farmer welfare by safeguarding farmers’ incomes against vagaries in crop price and (ii) improve consumer surplus by ensuring sufficient crop production. Among different mechanisms to operationalize an MSP scheme, we focus on credit-based MSPs under which the government credits farmers should the prevailing market price be below the prespecified MSP. By accounting for the implementation cost of the MSP, we examine the effectiveness of the MSP in terms of net benefit (i.e., farmer’s surplus minus the implementation cost) and net social value (i.e., sum of farmer’s and consumer’s surpluses minus the implementation cost) in a market that consists of risk-averse farmers with heterogeneous production costs. Also, farmers face two types of uncertainties: (1) market and (2) production yield uncertainty. We find that a credit-based MSP can induce crop production, which is intuitive. However, we find some more interesting results: (i) offering a higher MSP may not improve farmer’s surplus, (ii) the net benefit of an MSP can be negative—the cost of offering an MSP can exceed the farmer’s surplus, and (iii) there exists an MSP that maximizes the net social value. We extend our single-crop model to the case of two crops to capture the intercrop MSP interaction. We show that when one crop is more rewarding but riskier than the other crop, then it is sufficient to offer an appropriate MSP for one of the two crops while offering no MSP to the other crop. This paper was accepted by Vishal Gaur, operations management.
Missing Women in Tech: The Labor Market for Highly Skilled Software Engineers
Authors: Murciano-Goroff Raviv 
Published: September 2021

This paper examines the behavior of job seekers and recruiters in the labor market for software engineers. I obtained data from a recruiting platform where individuals can self-report their computer programming skills and recruiters can message individuals they wish to contact about job opportunities. I augment this data set with measures of each individual’s previous programming experience based on analysis of actual computer source code they wrote and shared within the open-source software community. This novel data set reveals that candidates’ self-reported technical skills are quantitatively important predictors of recruiter interest. Consistent with social psychology and behavioral economics studies, I also find female programmers with previous experience in a programming language are 11.07% less likely than their male counterparts to self-report knowledge of that programming language on their resume. Despite public pronouncements, however, recruiters do not appear more inclined toward recruiting female candidates who self-report knowing programming languages. Indeed, recruiters are predicted to be 6.47% less likely to express interest in a female candidate than a male candidate with comparable observable qualifications even if those qualifications are very strong. Ultimately, a gender gap in the self-reporting of skills on resumes exists; but recruiters do not appear to be adjusting their response to such signals in ways that could increase the representation of women among software engineering recruits. This paper was accepted by Yan Chen, behavioral economics and decision analysis.
Casting Light on the Hidden Bilevel Combinatorial Structure of the Capacitated Vertex Separator Problem
Authors: Fabio Furini , Ivana Ljubić , Enrico Malaguti , Paolo Paronuzzi 
Published: September 2021

Exploiting Bilevel Optimization Techniques to Disconnect Graphs into Small Components In order to limit the spread of possible viral attacks in a communication or social network, it is necessary to identify critical nodes, the protection of which disconnects the remaining unprotected graph into a bounded number of shores (subsets of vertices) of limited cardinality. In the article “'Casting Light on the Hidden Bilevel Combinatorial Structure of the Capacitated Vertex Separator Problem”, Furini, Ljubic, Malaguti, and Paronuzzi provide a new bilevel interpretation of the associated capacitated vertex separator problem and model it as a two-player Stackelberg game in which the leader interdicts (protects) the vertices, and the follower solves a combinatorial optimization problem on the resulting graph. Thanks to this bilevel interpretation, the authors derive different families of strengthening inequalities and show that they can be separated in polynomial time. The ideas exploited in their framework can also be extended to other vertex/edge deletion/insertion problems or graph partitioning problems by modeling them as two-player Stackelberg games to be solved through bilevel optimization.
Knowledge of stoma care among nurses working in acute settings: an integrated review
Authors: Dunne Aisling , Doody Owen , Bradshaw Carmel 
Published: September 2021

Background: Ostomy formation is life-changing surgery, and patient numbers are increasing globally. Knowledge of stoma care and management among nurses in acute settings is vital to provide holistic care, support patients' return to normal life and prevent complications. Aim: To estimate the knowledge of stoma care among nurses working in acute settings using an integrative review. Method: Five databases were searched between 2009 and 2020. A methodological approach for integrative reviews and a thematic analysis framework were used to identify themes from 10 papers. Reporting followed PRISMA guidelines, and quality appraisal was conducted. Findings: Nurses working in acute care settings have limited knowledge of stoma care, and confidence in care provision to patients with ostomies is affected by a lack of exposure. Confusion exists regarding the responsibilities of nurses when stoma care is required for an inpatient. Conclusion: Knowledge deficits regarding stoma care need to be addressed via exposure and support to deliver stoma care, access to evidence-based policies and protocols and clear referral pathways.
Understanding the pharmacology of heart failure
Authors: Easa Jamshid , Easa Najma , Chappell Jacob , Warriner David 
Published: September 2021

The prevalence of heart failure is increasing worldwide. Jamshid Easa, Najma Easa, Jacob Chappell and David Warriner provide an overview of the pharmacology of the drugs used to manage the condition Heart failure (HF) is a common clinical syndrome with ever-increasing prevalence in the Western world. It is associated with extensive morbidity and mortality, as well as being a significant burden on global healthcare systems. It is due to impairment of ventricular filling or contraction, resulting in a constellation of physical symptoms and signs, primarily due to salt and water retention. An understanding of the pharmacological options to manage the condition is imperative to quickly alleviate symptoms and avert a rapidly progressive downward spiral, improving not only quality but also quantity of life.
Compassion in leadership: staff morale and burnout
Authors: Odell Jennifer 
Published: September 2021

Increased work-related stress and burnout has been reported in nursing. Jennifer Odell explores the impact of leadership on the wider team An awareness of the impact of leadership is central to the challenge of understanding and upholding the delivery of compassionate patient care. The increasing scope of nursing practice in primary care and the challenge of meeting rising patient and colleague expectations to alleviate pressure and improve access has led to increased work-related stress. An understanding and evaluation of leadership in the nursing team, and the wider practice team, will help promote cohesion and a renewed focus on a positive and optimistic team attitude.
48 -cm-long room-temperature cavities in vertical and horizontal orientations for Sr optical clock
Authors: Zhadnov N. O. , Kudeyarov K. S. , Kryuchkov D. S. , Vishnyakova G. A. , Khabarova K. Yu. , Kolachevsky N. N. 
Published: September 2021

The development of an optical clock with ultimate accuracy and stability requires lasers with very narrow linewidths. We present two ultrastable laser systems based on 48-cm-long Fabry–Perot cavities made of ultralow expansion glass in horizontal and vertical configurations operating at 698 nm. Fractional frequency instability of the beat signal between the two lasers reaches

1.6

×

10

−
15

at the averaging time of 1 s. We experimentally characterized the contribution of the different noise sources (power fluctuations, residual amplitude modulation, the Doppler noise, and sensitivity to the shock impact) and found that in our case the laser frequency instability to a large extent is determined by an optoelectronic feedback loop. Although the vertical configuration was easier to manufacture and transport, it is much more sensitive to acoustics and horizontal accelerations compared to the horizontal one. Both laser systems were transported over a 60 km distance from the Lebedev Physical Institute to the All-Russian Scientific Research Institute for Physical-Engineering and Radiotechnical Metrology (VNIIFTRI), where they serve as local oscillators for spectroscopy of the clock transition in the recently developed strontium optical clock.
Few-cycle mid-infrared laser based on nonlinear self-compression in solid thin plates
Authors: Qian Junyu , Peng Yujie , Li Yanyan , Shao Beijie , Liu Zhe , Li Wenkai , Feng Renyu , Shen Liya , Leng Yuxin , Li Ruxin 
Published: September 2021

A few-cycle mid-infrared (MIR) laser is demonstrated via nonlinear self-compression in solid thin plates. In this novel solution, the anomalous material dispersion in the MIR band and the chirp induced by self-phase modulation are mutually compensated, which can achieve self-compression. Finally, with the 4 µm laser injection with 4.8 mJ/155 fs and few-cycle pulses with 3.44 mJ, 29.4 fs are generated with a high efficiency of 71.7%, and the system maintains very good spectral stability in 10 days. Compared with other post-compression methods, this self-compression technique has the advantages of high efficiency and robust and large energy expansion scale, which can be further extended to MIR lasers with other wavelengths and higher peak power.
Refractive index sensing and switching of leaky states in a metasurface
Authors: Muhammad Naseer , Wang Guo Ping 
Published: September 2021

We theoretically propose leaky states in an electro-optic (EO)-based all-dielectric metasurface. The EO substrate tunes leaky modes to the desired wave band with changes in applied voltage (

V

a
p
p

). For refractive index (RI) sensing, the highest figure-of-merit (FoM) in this work is 9166, quality factor (

Q

-factor) is

1.7450

e

4

, sensitivity is 407 nm/RIU (in RI range of 1.00–1.03), minimum detectable RI is

1.0542

e

−
4

, and relative sensitivity is

9.94

e

−
4

V

−
1

. The structure sustains the figure and line shape of leaky modes, high

Q

-factor, and FoM at different

V

a
p
p

and EO-coefficients. Our FoM and

Q

-factor are high, and the minimum detectable RI is smaller than previously reported. The giant

Q

-factor is promising for optical filters, modulation, and slow-light device applications.
The role of local impedance drop in the acute lesion efficacy during pulmonary vein isolation performed with a new contact force sensing catheter—A pilot study
Authors: Szegedi Nándor , Salló Zoltán , Perge Péter , Piros Katalin , Nagy Vivien Klaudia , Osztheimer István , Merkely Béla , Gellér László 
Published: September 2021

Introduction
Our pilot study aimed to evaluate the role of local impedance drop in lesion formation during pulmonary vein isolation with a novel contact force sensing ablation catheter that records local impedance as well and to find a local impedance cut-off value that predicts successful lesion formation.

Materials and methods
After completing point-by-point radiofrequency pulmonary vein isolation, the success of the applications was evaluated by pacing along the ablation line at 10 mA, 2 ms pulse width. Lesions were considered successful if loss of local capture was achieved.

Results
Out of 645 applications, 561 were successful and 84 were unsuccessful. Compared to the unsuccessful ablation points, the successful applications were shorter (p = 0.0429) and had a larger local impedance drop (p<0.0001). There was no difference between successful and unsuccessful applications in terms of mean contact force (p = 0.8571), force-time integral (p = 0.0699) and contact force range (p = 0.0519). The optimal cut-point for the local impedance drop indicating successful lesion formation was 21.80 Ohms on the anterior wall [AUC = 0.80 (0.75–0.86), p<0.0001], and 18.30 Ohms on the posterior wall [AUC = 0.77 (0.72–0.83), p<0.0001]. A local impedance drop larger than 21.80 Ohms on the anterior wall and 18.30 Ohms on the posterior wall was associated with an increased probability of effective lesion creation [OR = 11.21, 95%CI 4.22–29.81, p<0.0001; and OR = 7.91, 95%CI 3.77–16.57, p<0.0001, respectively].

Conclusion
The measurement of the local impedance may predict optimal lesion formation. A local impedance drop > 21.80 Ohms on the anterior wall and > 18.30 Ohms on the posterior wall significantly increases the probability of creating a successful lesion.