bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensor applications to measure health and movement among health care personnel at workplace: A scoping review protocol
Authors: Välimäki Maritta , Hipp Kirsi , Chen Jiarui , Huang Xiaoting , Guo Jia , Wong Man Sing 
Published: January 2021

Abstract
BackgroundThe well-being and health of health care personnel is becoming increasingly important in the delivery of high-quality healthcare. Monitoring technologies provide new opportunities for the objective measurement of activities and behaviours related to well-being and health. However, these possible technologies used by health care personnel have not been fully synthesised. The overall aim of this scoping review is to examine what technologies are available to monitor health care personnel’s health, well-being and activities in workplace settings. More specifically, we want to explore how, by whom and for what purposes sensor applications have been used by health care personnel at different workplace settings.MethodsThis scoping review protocol will follow Arksey’s and O’Malley’s methodology, complimented by the approach of the Joanna Briggs Institute to scoping reviews. Peer-reviewed literature will be identified using a search strategy developed by a librarian, and a wide range of electronic datasets of medical, computer and information systems disciplines will be used. Eligibility of the articles will be determined using a two-stage screening process consisting of (1) a title and abstract scan, and (2) a full text review. Extracted data will be thematically analysed and validated by an expert of sensor technology and a group of nurses as stakeholders. Descriptive statistics will be calculated when necessary.DiscussionThis scoping review will examine what technologies are available to monitor health care personnel’s health, well-being and activities in workplace settings. The results obtained from the review will inform the suitability of monitoring technology used in health care settings, what methods are already available for use in research and technology might still be needed for future innovations. Findings of the scoping review will be published in a peer-reviewed journal.Systematic review registrationThis review was submitted in Open Science Framework on 12 December 2020.
Flipped Classroom Combined With Case-based Learning Is an Effective Teaching Modality in Nephrology Clerkship
Authors: Yang Fuye , Lin Wanbing , Wang Yan 
Published: January 2021

Abstract
BackgroundBoth flipped classroom (FC) and case-based learning (CBL) are recognized as new effective teaching approaches by emphasizing on different aspects of teaching activities; however, the implementation of FC combined with CBL has not been well explored in nephrology education. The present study aims to investigate the efficacy of FC combined with CBL in teaching nephrology via comparing with the traditional lecture-based teaching (LBT). MethodsSixty-two medical clerkship students at Zhejiang University School of Medicine were equally allocated into either LBT or FC group demographically matched. The glomerular diseases module was chosen for the teaching content. Students from the FC group were required to study the pre-class materials in annotated PPT format before the face-to face discussion on the relevant cases during the class. Students from the LBT group attended a didactic lecture during the class. Quiz and questionnaires were performed to assess the efficacy of FC. ResultsParticipants from the FC group performed better than those from the LBT group in the quiz with higher scores in the case analysis-related questions. FC was also considered more helpful than LBT in improving high order cognitive abilities in the survey. Meanwhile, more participants agreed increased in-class pressure in FC than in LBT. ConclusionsThis study shows the positive impact of FC combined with CBL approach on nephrology education and provides an alternative pre-class and in-class format for the FC implementation.
Genetic investigation of 211 Chinese families expands the mutational and phenotypical spectrum in hereditary retinopathy genes through targeted sequencing technology
Authors: Bai Zhouxian , Xie Yanchuan , Liu Lina , Shao Jingzhi , Liu Yuying , Kong Xiangdong 
Published: January 2021

Abstract
Background: Hereditary retinopathy is a significant cause of blindness worldwide. Despite the discovery of many mutations in various retinopathies, a large part of patients remain undiagnosed genetically. Targeted next generation sequencing of the human genome is a suitable approach for retinopathy molecular diagnosis.Methods: We described a cohort of 211 families from central China with various forms of retinopathy, 95 families of which were investigated using NGS multi-gene panel sequencing as well as the other 116 patients were LHON suspected tested by Sanger sequencing. We validated the candidate variants by PCR-based Sanger sequencing. We have made comprehensive analysis of the cases through sequencing data and ophthalmologic examination information.Results: The potentially causal mutation was identified in majority of the families with retinopathy (57.9% of 95 families) and Leber hereditary optic neuropathy (LHON) (21.6% of 116 families). The identified mutations (68mutations, 37 of which are novel) of the 95 families spanned 31 known disease genes, about half have not been reported relation to hereditary retinopathy. The NGS panel solution provides 45.3% potential diagnostic rate of the retinopathy families and another 12.6% families detect candidate gene mutations with undefined pathogenicity in this study.Conclusion: Our study showed novel mutations and phenotypic aspects of retinopathy, and demonstrated genetic and clinical heterogeneity of the conditions. Our results illustrated the significance of molecular genetic testing for patients with hereditary retinopathy.
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network and the potential prognosis indicators in sarcomas
Authors: Gao Lu , Zhao Yu , Ma Xuelei , Zhang Ling 
Published: January 2021

Abstract
Background: Competitive endogenous RNA (ceRNA) has revealed a new mechanism of interaction between RNAs and been demonstrated to play crucial roles in multiple biological processes and in the development of neoplasms that potentially serve as diagnostic and prognosis markers as well as therapeutic targets.Methods：In this work, we identified differentially expressed mRNAs (DEGs), lncRNAs (DELs) and miRNAs (DEMs) in sarcoma by comparing the genes expression profiles between sarcoma samples and normal tissue samples in Gene Expression Omnibus (GEO) datasets. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were applied to investigate the primary functions of the overlapped DEGs. Then, lncRNA-miRNA and miRNA-mRNA interactions were predicted, and the ceRNA regulatory network was constructed in Cytoscape. In addition, the protein-protein interaction (PPI) network was constructed and survival analysis was performed.Results: A total of 1296 DEGs were identified in sarcoma samples by combining the GO and KEGG pathway enrichment analyses, 338 DELs were discovered after the probes were reannotated, and 36 DEMs were ascertained through intersecting two different expression miRNAs sets. Further, through target gene prediction, a lncRNA-miRNA-mRNA ceRNA network that contained 113 mRNAs, 69 lncRNAs and 29 miRNAs was constructed. The PPI network identified the six most significant hub proteins. Survival analysis revealed that seven mRNAs, four miRNAs and one lncRNA were associated with overall survival of sarcoma patients.Conclusions: Overall, we constructed a ceRNA network in sarcomas, which likely provides insights for further research on the molecular mechanism and potential prognosis biomarkers.
A comparison of standard occupational therapy versus early enhanced occupation-based therapy in a medical / surgical intensive care unit: study protocol for a single site feasibility trial (EFFORT-ICU).
Authors: Rapolthy-Beck Andrea , Fleming Jennifer , Turpin Merrill , Sosnowski Kellie , Dullaway Simone , White Hayden 
Published: January 2021

Abstract
Background: Admissions to intensive care units (ICUs) are increasing due to an aging population, and rising incidence of cardiac and respiratory disease. With advances in medical care, more patients are surviving an initial stay in critical care; however, they can experience ongoing health and cognitive limitations, that may influence return to baseline function up to a year post-admission. Recent research has focused on the introduction of early rehabilitation within the ICU to reduce long-term physical and cognitive complications. The aim of this study is to explore the feasibility and impact of providing early enhanced occupation-based therapy, including cognitive stimulation and activities of daily living, to patients in intensive care. Methods: This study involves a single site randomised-controlled feasibility trial comparing standard occupational therapy care to an early enhanced occupation-based therapy. Thirty mechanically ventilated ICU patients will be recruited and randomly allocated to the intervention or control group. The primary outcome measure is the Functional Independence Measure (FIM), and secondary measures include the Modified Barthel Index (MBI), Montreal Cognitive Assessment (MoCA), grip strength, Hospital Anxiety and Depression Scale (HADS) and Short-Form 36 Health survey (SF-36). Measures will be collected by a blind assessor at discharge from intensive care, hospital discharge and a 90-day follow-up. Daily outcome measures including the Glasgow Coma Scale (GCS), Richmond Agitation and Sedation Scale (RASS) and Confusion Assessment Measure for intensive care units (CAM-ICU) will be taken prior to treatment. Participants in the intervention group will receive daily a maximum of up to 60 minute sessions with an occupational therapist involving cognitive and functional activities such as self-care and grooming. At the follow-up, intervention group participants will be interviewed to gain user perspectives of the intervention. Feasibility data including recruitment and retention rates will be summarised descriptively. Parametric tests will compare outcomes between groups. Interview data will be thematically analysed.Discussion: This trial will provide information about the feasibility of investigating how occupational therapy interventions in ICU influence longer term outcomes. It seeks to inform the design of a phase III multicentre trial of occupational therapy in critical care general medical intensive care units.Trial registration: Australia New Zealand Clinical Trials Registry (ANZCTR): ACTRN12618000374268; prospectively registered on 13th March 2018 / https://www.anzctr.org.auTrial funding: Metro South Health Research Support Scheme Postgraduate Scholarship
Neuroprotective effects of Shende’an tablet in the Parkinson’s disease model
Authors: Sheng Xiao Yan , Yang Shui Yuan , Wen Xiao Min , Zhang Xin , Ye Yong Feng , Zhao Peng , Zang Min Li , Peng Kang , Du En Ming , Li Sai 
Published: January 2021

Abstract
Background: Shende’an tablet (SDA) is a newly capsuled Chinese herbal formula derived from the Chinese traditional medicine Zhengan Xifeng Decoction which is approved for the treatment of neurasthenia and insomnia in China. This study aimed to investigate the neuroprotective effects of SDA against Parkinson’s disease (PD) in vitro and in vivo.Methods: In the present work, the neuroprotective effects and mechanism of SDA were evaluated in the cellular PD model. Male C57BL/6J mice were subject to a partial MPTP lesion alongside treatment with SDA. Behavioural test and tyrosine-hydroxylase immunohistochemistry were used to evaluate nigrostriatal tract integrity. HPLC analysis and Western blotting were used to assess the effect of SDA on dopamine metabolism and the expression of HO-1, PGC-1α and Nrf2, respectively.Results: Our results demonstrated that SDA had neuroprotective effect in dopaminergic PC12 cells with 6-OHDA lesion. It had also displayed efficient dopaminergic neuronal protection and motor behavior alleviation properties in MPTP-induced PD mice. In the PC12 cells and MPTP-induced Parkinson’s disease animal models, SDA was highly efficacious in α-synuclein clearance associated with the activation of PGC-1α/Nrf2 signal pathway.Conclusion: SDA demonstrated potential as a future therapeutic modality in PD through protecting dopamine neurons and alleviating the motor symptoms, mediated by the activation of PGC-1α/Nrf2 signal pathway.
Cost-effectiveness of paclitaxel, doxorubicin, cyclophosphamide and trastuzumab versus docetaxel, cisplatin and trastuzumab in new adjuvant therapy of breast cancer in china.
Authors: XU Qiaoping , Yuanyuan LI , Jiejing ZHU , Jian Liu , Qingyu LI , Lingya Chen , Ying LUO , Changchen SHI , Yangling LI , Wei YAN 
Published: January 2021

Abstract
Background: Breast cancer is the most common cancer among women in China. Amplification of the Human epidermal growth factor receptor type 2 (HER2) gene is present and overexpressed in 18–20% of breast cancers and historically has been associated with inferior disease-related outcomes. There has been increasing interest in de-escalation of therapy for low-risk disease. This study analyzes the cost-effectiveness of Doxorubicin/ Cyclophosphamide/ Paclitaxel/ Trastuzumab (AC-TH) and Docetaxel/Carboplatin/Trastuzumab(TCH) from payer perspective over a 5 year time horizon.Methods: A half-cycle corrected Markov model was built to simulate the process of breast cancer events and death occurred in both AC-TH and TCH armed patients. Cost data came from studies based on a Chinese hospital. One-way sensitivity analyses as well as second-order Monte Carlo and probabilistic sensitivity analyses were performed.The transition probabilities and utilities were extracted from published literature, and deterministic sensitivity analyses were conducted.Results:We identified 41 breast cancer patients at Hangzhou First People’s Hospital, among whom 15(60%) had a partial response for AC-TH treatment and 13 (81.25%) had a partial response for TCH treatment.No cardiac toxicity was observed. Hematologic grade 3 or 4 toxicities were observed in 1 of 28 patients.Nonhematologic grade 3 or 4 toxicities with a reverse pattern were observed in 6 of 29 patients. The mean QALY gain per patient compared with TCH was 0.25 with AC-TH, while the incremental costs were $US13,142.The incremental cost-effectiveness ratio (ICER) of AC-TH versus TCH was $US 52,565 per QALY gained.Conclusions: This study concluded that TCH neoadjuvant chemotherapy was feasible and active in HER2-overexpressing breast cancer patients in terms of the pathological complete response, complete response, and partial response rates and manageable toxicities.
Simulation in Physiotherapy Students for Clinical Decisions during Interaction with People with Low Back Pain. Randomized Controlled Trial
Authors: Sandoval-Cuellar Carolina , Alfonso-Mora Margareth Lorena , Castellanos-Garrido Adriana Lucia , Villarraga-Nieto Angélica del Pilar , Goyeneche-Ortegón Ruth Liliana , Acosta-Otalora Martha Lucia , Castellanos-Vega Rocio del Pilar , Cobo-Mejía Elisa Andrea 
Published: January 2021

Abstract
Background: Low back pain (LBP) is a symptomatology with a high global prevalence; health professionals, including physiotherapists, must have the skills to create professional actions that increase a quality of life for patients. Clinical simulation can be a pedagogic strategy that facilitates in students adequate training to acquire skills that improve professional reasoning in this clinical situation. The objective of this study was to compare the effects of clinical simulation with simulated patient (SP) versus simulation with role playing (RP) in physiotherapy students for decision-making in clinical skills while caring for a person with LBP. Methods. Experimental study, with 42 participants from two Colombian universities, randomized into two groups (SP n = 21, RP n = 21). The clinical skill was evaluated during the interaction with a person with LBP for which the Objective Structured Clinical Examination (OSCE-LBP) was validated for individuals with low back pain; thereafter, a pedagogical method was conducted that included clinical simulation and, finally, the OSCE-LBP was applied again to compare both groups.Results. Changes occurred in the OSCE-LBP among both groups of students: the scores increased (0.66 and 0.59 in RP and SP, respectively), and neither of the two was superior (difference 0.01 95%CI -0.21 to 0.23). ﻿Conclusion. Both types of simulation favour decision-making in professional reasoning in physiotherapy students during interaction with individuals with LBP.Contribution of paper: This is an RCT that explores the use of clinical simulation with simulated patient as a teaching method in decision making by physiotherapists versus traditional use of role playing
Specialty career preferences among final year medical students at Makerere University College of Health Sciences, Uganda: A mixed methods study
Authors: Kuteesa Job , Musiime Victor , Munabi Ian G. , Mubuuke Aloysius G. , Opoka Robert , Mukunya David , Kiguli Sarah 
Published: January 2021

Abstract
Background: Uganda has an imbalanced distribution of the health workforce, which may be influenced by the specialty career preferences of medical students. In spite of this, there is inadequate literature concerning the factors influencing specialty career preferences. We aimed to determine the specialty career preferences and the factors influencing the preferences among fifth year medical students in the School of Medicine, Makerere University College of Health Sciences (MakCHS). Methods: A sequential explanatory mixed methods study design with a descriptive cross-sectional study followed by a qualitative study was used. A total of 135 final year medical students in MakCHS were recruited using consecutive sampling. Self-administered questionnaires and three focus group discussions were conducted. Quantitative data was analysed in STATA version 13 (StataCorp, College Station, Tx, USA) using descriptive statistics, chi-square tests and logistic regression. Qualitative data was analysed in NVIVO version 12 (QRS International, Cambridge, MA) using content analysis.Results: Of 135 students 91 (67.4%) were male and their median age was 24 years (IQR: 24, 26). As a first choice, the most preferred specialty career was obstetrics and gynecology (34/135, 25.2%), followed by surgery (27/135, 20.0%), pediatrics (18/135, 13.3%) and internal medicine (17/135, 12.6%). Non-established specialties such as anesthesia and Ear Nose and Throat (ENT) were not selected as a first choice by any student. Female students had 63% less odds of selecting surgical related specialties compared to males (aOR=0.37, 95%CI: 0.17-0.84). The focus group discussions highlighted controlled lifestyle, assurance of a good life through better financial remuneration and inspirational specialists as facilitators for specialty preference. Bad experience during the clinical rotations, lack of career guidance plus perceived poor and miserable specialists were highlighted as barriers to specialty preference.Conclusion. Obstetrics and Gynecology, Surgery, Pediatrics and Internal Medicine are well-established disciplines, which were dominantly preferred. Females were less likely to select surgical disciplines as a career choice. Therefore, there is a need to implement or establish career guidance and mentorship programs to attract students to the neglected disciplines.
Characteristics and Treatments for Pediatric Ordinary and Incarcerated Inguinal Hernia Based on Gender: 12-Year Experiences from a Single Center
Authors: Wang Kai , Tan Sarah Siyin , Xiao Yue , Wang Zengmeng , Peng Chunhui , Pang Wenbo , Wu Dongyang , Chen Yajun 
Published: January 2021

Abstract
Background: Congenital primary inguinal hernia is a common condition among children. Although much literature regarding inguinal hernia is available, large scale analysis are few, and rarely do they expand on gender difference or incarcerated hernias.Methods: Patients with unilateral or bilateral inguinal hernia who were admitted to our hospital and received open inguinal hernia repair (OIHR) or laparoscopic inguinal hernia repair (LIHR) under general anesthesia were included. LIHR was performed using single-site laparoscopic percutaneous extraperitoneal closure (SLPEC). Medical records were retrospectively collected and analyzed.Results: A total of 12190 patients were included in this study. The ratio of male to female was 4.8:1. There was a total of 10646 unilateral hernias (87.3%) and 1544 bilateral hernias (12.7%), with a corresponding ratio of 6.9:1. 12444 hernia repair surgeries, 11083 (89.1%) OIHR and 1361 (10.9%) LIHR, were held.OIHR had a shorter operative time than LIHR for all unilateral and female bilateral repair, unlike for bilateral male repair. There was no difference between OIHR and LIHR for ipsilateral recurrent hernia in males. There was a difference between OIHR and LIHR for metachronous contralateral hernia.Incarcerated inguinal hernia was associated with longer operative time, hospital stay and higher hospital costs. Females and patients under 1 year were more likely to present with incarcerated hernia.Conclusions: OIHR should be considered for male patients, especially for unilateral and complete inguinal hernia. LIHR is highly recommended for female patients. For incarcerated hernia, attention should be paid to patients under 1 year old, as they can be 60 times more susceptible, and females. Surgeons should also be aware of ovary hernias in females.
A Pilot Study of Team-based Learning in Paediatric Clerkships
Authors: Xu Luojia , Zhang Yuanyuan , Chen Yifang , Xu Yingchun , Wang Yujia , Chen Zhimin , Shu Qiang 
Published: January 2021

Abstract
Background: Team-based learning (TBL) is widely used in health profession education. However, the use of TBL in paediatric clerkships is rare. In this study, we explore the efficacy and feasibility of TBL in paediatric clerkships. Methods: We retrospectively reviewed the TBL course for paediatric clerkships from August to October 2019 at the Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China. The TBL group (with 107 students) was compared to the students from the prior year who learned via case-based discussion (control group with 222 students). The learning outcomes were measured using theoretical exams when the paediatric clerkships ended. The satisfaction with TBL was evaluated by an anonymous questionnaire administered to the TBL group. Results: The grade point averages before paediatric clerkships in the TBL group (3.58, 3.04-3.96) were similar to those in the control group (3.62, 3.16-4.00) (p=0.839). However, the theoretical exam scores in the TBL group (76, 67-82) were significantly higher than those in the control group (72, 64-78) (p=0.002). In addition, 92.5% of the students in the TBL group rated their level of satisfaction higher than 90%. Conclusions: Our study demonstrated that TBL in paediatric clerkships was effective and feasible and that it led to better learning outcomes.