bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of quantitative trait loci associated with upper temperature tolerance in turbot, Scophthalmus maximus
Authors: Ma Aijun , Huang Zhihui , Wang Xin-an , Xu Yuhui , Guo Xiaoli 
Published: November 2021

AbstractTemperature tolerance is an important trait from both an economic and evolutionary perspective in fish. Because of difficulties with measurements, genome-wide selection using quantitative trait loci (QTLs) affecting Upper temperature tolerance may be an alternative for genetic improvement. Turbot Scophthalmus maximus (L.) is a cold-water marine fish with high economic value in Europe and Asia. The genetic bases of upper temperature tolerance (UTTs) traits have been rarely studied. In this study, we constructed a genetic linkage map of turbot using simple sequence repeats (SSRs) and single nucleotide polymorphism (SNP) markers. A total of 190 SSR and 8,123 SNP were assigned to 22 linkage groups (LGs) of a consensus map, which spanned 3,648.29 cM of the turbot genome, with an average interval of 0.44 cM. Moreover, we re-anchored genome sequences, allowing 93.8% physical sequences to be clustered into 22 turbot pseudo-chromosomes. A high synteny was observed between two assemblies from the literature. QTL mapping and validation analysis identified thirteen QLTs which are major effect QTLs, of these, 206 linked SNP loci, and two linked SSR loci were considered to have significant QTL effects. Association analysis for UTTs with 129 QTL markers was performed for different families, results showed that eight SNP loci were significantly correlated with UTT, which markers could be helpful in selecting thermal tolerant breeds of turbot. 1,363 gene sequences were genomically annotated, and 26 QTL markers were annotated. We believe these genes could be valuable candidates affecting high temperatures, providing valuable genomic resources for the study of genetic mechanisms regulating thermal stress. Similarly, they may be used in marker-assisted selection (MAS) programs to improve turbot performance.
Uncovering associations between data-driven learned qMRI biomarkers and chronic pain
Authors: Morales Alejandro G. , Lee Jinhee J. , Caliva Francesco , Iriondo Claudia , Liu Felix , Majumdar Sharmila , Pedoia Valentina 
Published: November 2021

AbstractKnee pain is the most common and debilitating symptom of knee osteoarthritis (OA). While there is a perceived association between OA imaging biomarkers and pain, there are weak or conflicting findings for this relationship. This study uses Deep Learning (DL) models to elucidate associations between bone shape, cartilage thickness and T2 relaxation times extracted from Magnetic Resonance Images (MRI) and chronic knee pain. Class Activation Maps (Grad-CAM) applied on the trained chronic pain DL models are used to evaluate the locations of features associated with presence and absence of pain. For the cartilage thickness biomarker, the presence of features sensitive for pain presence were generally located in the medial side, while the features specific for pain absence were generally located in the anterior lateral side. This suggests that the association of cartilage thickness and pain varies, requiring a more personalized averaging strategy. We propose a novel DL-guided definition for cartilage thickness spatial averaging based on Grad-CAM weights. We showed a significant improvement modeling chronic knee pain with the inclusion of the novel biomarker definition: likelihood ratio test p-values of 7.01 × 10–33 and 1.93 × 10–14 for DL-guided cartilage thickness averaging for the femur and tibia, respectively, compared to the cartilage thickness compartment averaging.
Description of five new species of the Madagascan flagship plant genus Ravenala (Strelitziaceae)
Authors: Haevermans Thomas , Hladik Annette , Hladik Claude-Marcel , Razanatsoa Jacqueline , Haevermans Agathe , Jeannoda Vololoniaina , Blanc Patrick 
Published: November 2021

AbstractMadagascar’s emblematic traveller’s tree is a monospecific genus within Strelitziaceae, the family of the South African bird of paradise. Until now, this endemic genus consisted of a single species: Ravenala madagascariensis Sonn., which is grown everywhere in the tropics as an ornamental plant. The plant is immediately recognizable for its huge fan-forming banana-like leaves and is locally referred to in Magagascar by several vernacular names. “Variants” have been mentioned in the literature, but without any attempt to recognize formal taxa based on diagnostic features. In this paper, we formally describe five new species and fix the application of the name R. madagascariensis to the populations growing on the eastern coast of Madagascar, with the epitype growing in the marshy Fort-Dauphin area in the south. This paper has numerous implications for conservation biology and other domains of life sciences, due to the importance of this genus for the conservation of Madagascan ecosystems, the ornamental plant trade, as well as for its invasive status in several tropical areas.
Lack of affective priming indicates attitude-behaviour discrepancy for COVID-19 affiliated words
Authors: Moro Stefania S. , Steeves Jennifer K. E. 
Published: November 2021

AbstractThe ongoing novel coronavirus (COVID-19) pandemic has resulted in the enforcement of national public health safety measures including precautionary behaviours such as border closures, movement restrictions, total or partial lockdowns, social distancing, and face mask mandates in order to reduce the spread of this disease. The current study uses affective priming, an indirect behavioural measure of implicit attitude, to evaluate COVID-19 attitudes. Explicitly, participants rated their overall risk perception associated with contracting COVID-19 significantly lower compared to their perception of necessary precautions and overall adherence to public health measures. During baseline trials, participants explicitly rated COVID-19 affiliated words as unpleasant, similar to traditional unpleasant word stimuli. Despite rating the COVID-19 affiliated words as unpleasant, affective priming was not observed for congruent prime-target COVID-19 affiliated word pairs when compared to congruent prime-target pleasant and unpleasant words. Overall, these results provide quantitative evidence that COVID-19 affiliated words do not invoke the same implicit attitude response as traditional pleasant and unpleasant word stimuli, despite conscious explicit rating of the COVID-19 words as unpleasant. This reduction in unpleasant attitude towards COVID-19 related words may contribute towards decreased fear-related behaviours and increased incidences of risky-behaviour facilitating the movement of the virus.
Adapting the visuo-haptic perception through muscle coactivation
Authors: Carboni Gerolamo , Nanayakkara Thrishantha , Takagi Atsushi , Burdet Etienne 
Published: November 2021

AbstractWhile the nervous system can coordinate muscles’ activation to shape the mechanical interaction with the environment, it is unclear if and how the arm’s coactivation influences visuo-haptic perception and motion planning. Here we show that the nervous system can voluntarily coactivate muscles to improve the quality of the haptic percept. Subjects tracked a randomly moving visual target they were physically coupled to through a virtual elastic band, where the stiffness of the coupling increased with wrist coactivation. Subjects initially relied on vision alone to track the target, but with practice they learned to combine the visual and haptic percepts in a Bayesian manner to improve their tracking performance. This improvement cannot be explained by the stronger mechanical guidance from the elastic band. These results suggest that with practice the nervous system can learn to integrate a novel haptic percept with vision in an optimal fashion.
Amyloid-beta peptide (25–35) triggers a reorganization of lipid membranes driven by temperature changes
Authors: Ivankov Oleksandr , Murugova Tatiana N. , Ermakova Elena V. , Kondela Tomáš , Badreeva Dina R. , Hrubovčák Pavol , Soloviov Dmitry , Tsarenko Alexey , Rogachev Andrey , Kuklin Alexander I. , Kučerka Norbert 
Published: November 2021

AbstractThe amyloid-beta peptide (Aβ) is considered a key factor in Alzheimer's disease (AD) ever since the discovery of the disease. The understanding of its damaging influence has however shifted recently from large fibrils observed in the inter-cellular environment to the small oligomers interacting with a cell membrane. We studied the effect of temperature on the latter interactions by evaluating the structural characteristics of zwitterionic phosphatidylcholine (PC) membranes with incorporated Aβ25–35 peptide. By means of small angle neutron scattering (SANS), we have observed for the first time a spontaneous reformation of extruded unilamellar vesicles (EULVs) to discoidal bicelle-like structures (BLSs) and small unilamellar vesicles (SULVs). These changes in the membrane self-organization happen during the thermodynamic phase transitions of lipids and only in the presence of the peptide. We interpret the dramatic changes in the membrane's overall shape with parallel changes in its thickness as the Aβ25–35 triggered membrane damage and a consequent reorganization of its structure. The suggested process is consistent with an action of separate peptides or small size peptide oligomers rather than the result of large Aβ fibrils.
Multidisciplinary investigation reveals the earliest textiles and cinnabar-coloured cloth in Iberian Peninsula
Authors: Gleba Margarita , Bretones-García M. Dolores , Cimarelli Corrado , Vera-Rodríguez Juan Carlos , Martínez-Sánchez Rafael M. 
Published: November 2021

AbstractTextile production is among the most fundamental and more complex technologies in human prehistory, but is under-investigated due to the perishable nature of fibrous materials. Here we report a discovery of five textile fragments from a prehistoric (fourth-third millennium cal BC) burial deposit located in a small cave at Peñacalera in Sierra Morena hills, near Córdoba, Southern Spain. These textiles accompanied a set of human remains as grave goods, together with other organic elements such as fragments of wood and cork, and some pottery vessels. They were characterized and dated using digital microscopy, Scanning Electron Microscopy, Energy Dispersive Spectroscopy and Accelerator Mass Spectrometry. Two of the fragments described here are the oldest examples of loom-woven textiles in the Iberian Peninsula, dating from the second half of the fourth millennium cal BC. This correlates chronologically with the first appearance of loom weights in the archaeological record of this region. The more recently dated textile is the earliest preserved cloth intentionally coloured with cinnabar in the western Mediterranean. The Peñacalera finds are a key reference for understanding the development of textile technologies during the Neolithic and Copper Age in western Europe and beyond.
Design of hybrid narrow-band plasmonic absorber based on chalcogenide phase change material in the infrared spectrum
Authors: Alves Oliveira Israel , Gomes de Souza Igor Leonardo , Rodriguez-Esquerre Vitaly Felix 
Published: November 2021

AbstractStructures absorbing electromagnetic waves in the infrared spectral region are important optical components in key areas such as biosensors, infrared images, thermal emitters, and special attention is required for reconfigurable devices. We propose a three-dimensional metal-dielectric plasmonic absorber with a layer of PCM’s (Phase Change Materials). The phase shift effects of PCMs are numerically analyzed, and it is possible to obtain a shifting control of the resonant absorption peaks between the amorphous and crystalline states using the Lorentz–Lorenz relation. By using this empirical relation, we analyzed the peak absorption shift at intermediate phases between the amorphous and the crystalline. The geometric parameters of the structure with the PCM layer in the semi-crystalline state were adjusted to exhibit strong absorption for normal incidence. The effects of the oblique incidence on the absorption for the TM and TE polarization modes were also analyzed. Our results demonstrate that PCMs have great potential for reconfigurable nanophotonic devices.
Transplantation of rat cranial bone-derived mesenchymal stem cells promotes functional recovery in rats with spinal cord injury
Authors: Maeda Yuyo , Otsuka Takashi , Takeda Masaaki , Okazaki Takahito , Shimizu Kiyoharu , Kuwabara Masashi , Hosogai Masahiro , Yuge Louis , Mitsuhara Takafumi 
Published: November 2021

AbstractCell-based therapy using mesenchymal stem cells (MSCs) is a novel treatment strategy for spinal cord injury (SCI). MSCs can be isolated from various tissues, and their characteristics vary based on the source. However, reports demonstrating the effect of transplanted rat cranial bone-derived MSCs (rcMSCs) on rat SCI models are lacking. In this study, we determined the effect of transplanting rcMSCs in rat SCI models. MSCs were established from collected bone marrow and cranial bones. SCI rats were established using the weight-drop method and transplanted intravenously with MSCs at 24 h post SCI. The recovery of motor function and hindlimb electrophysiology was evaluated 4 weeks post transplantation. Electrophysiological recovery was evaluated by recording the transcranial electrical stimulation motor-evoked potentials. Tissue repair after SCI was assessed by calculating the cavity ratio. The expression of genes involved in the inflammatory response and cell death in the spinal cord tissue was assessed by real-time polymerase chain reaction. The transplantation of rcMSCs improved motor function and electrophysiology recovery, and reduced cavity ratio. The expression of proinflammatory cytokines was suppressed in the spinal cord tissues of the rats that received rcMSCs. These results demonstrate the efficacy of rcMSCs as cell-based therapy for SCI.
Pheromones that correlate with reproductive success in competitive conditions
Authors: Luzynski Kenneth C. , Nicolakis Doris , Marconi Maria Adelaide , Zala Sarah M. , Kwak Jae , Penn Dustin J. 
Published: November 2021

AbstractThe major urinary proteins (MUPs) of house mice (Mus musculus) bind and stabilize the release of pheromones and other volatile organic compounds (VOCs) from urinary scent marks, which mediate chemical communication. Social status influences MUP and VOC excretion, and the urinary scent of dominant males is attractive to females. Urinary pheromones influence the sexual behavior and physiology of conspecifics, and yet it is not known whether they also affect reproductive success. We monitored the excretion of urinary protein and VOCs of wild-derived house mice living in large seminatural enclosures to compare the sexes and to test how these compounds correlate with reproductive success. Among males, urinary protein concentration and VOC expression correlated with reproductive success and social status. Territorial dominance also correlated with reproductive success in both sexes; but among females, no urinary compounds were found to correlate with social status or reproductive success. We found several differences in the urinary protein and volatile pheromones of mice in standard cages versus seminatural enclosures, which raises caveats for conventional laboratory studies. These findings provide novel evidence for chemical signals that correlate with male reproductive success of house mice living in competitive conditions.
The coexistence of superior intrinsic piezoelectricity and thermoelectricity in two-dimensional Janus α-TeSSe
Authors: Chen Shaobo , Chen Xiangrong , Zeng Zhaoyi , Geng Huayun , Yin Huabing 
Published: November 2021

A new group-VI Janus ternary compounds α-TeSSe monolayer exhibits outstanding piezoelectric and thermoelectric performances, which has broad application prospects in the fields of piezoelectrics and thermoelectrics.
Surface active ionic liquid assisted metal-free electrocatalytic-carboxylation in aqueous phase: a sustainable approach for CO2 utilization paired with electro-detoxification of halocarbons
Authors: Pandit Sarwar Ahmad , Bhat Sajad Ahmad , Rather Mudasir Ahmad , Sofi Feroz Ahmad , Ingole Pravin P. , Manzoor Bhat Zahid , Thotiyl Musthafa Ottakam , Bhat Khursheed Ahmad , Rehman Shakeel U. , Bhat Mohsin Ahmad 
Published: November 2021

Electrocarboxylation of halocarbons in aqueous micellar solutions of Imidazolium based surface active ionic liquids offers a promising green strategy for capture, fixation and utilization of CO2 for the synthesis of high-added value compounds.
Effect of rs4646994 polymorphism of angiotensin-converting enzyme on the risk of nonischemic cardiomyopathy
Authors: Shen Jinsheng , Qian Xuesong , Mei Xiaofei , Yao Jialu , Jiang Hezi , Li Kexin , Chen Tan , Jiang Yufeng , Zhou Yafeng 
Published: November 2021

Abstract
Background: Angiotensin-converting enzyme (ACE) gene polymorphisms have recently been shown to be associated with risk of developing left ventricular hypertrophy (LVH). However, the results were controversial. We aimed to conduct this meta-analysis to further confirm the association between ACE rs4646994 polymorphism and hypertrophic cardiomyopathy (HCM)/dilated cardiomyopathy (DCM).
Methods: PubMed, Embase, the Chinese National Knowledge Information, and Wanfang databases were searched for eligible studies. The Newcastle–Ottawa Scale (NOS) was used to evaluate the quality of included studies. Then we evaluated the association between ACE gene mutation and HCM/DCM by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analysis was further performed to explore situations in specialized subjects. Sensitivity analysis and publication bias was assessed to confirm the study reliability.
Results: There were 13 studies on DCM (2004 cases and 1376 controls) and 16 studies on HCM (2161 controls and 1192 patients). ACE rs4646994 polymorphism was significantly associated with DCM in all genetic models. However, in HCM, four genetic models (allele model, homozygous model, heterozygous model, and dominant model) showed significant association between ACE rs4646994 polymorphism and DCM. In subgroup analysis, we found that ACE rs4646994 polymorphism was significantly associated with DCM/HCM in Asian population. Finally, we also conducted a cumulative meta-analysis, which indicates that the results of our meta-analysis are highly reliable.
Conclusion: ACE rs4646994 polymorphism increases the risk of DCM/HCM in Asians, but not in Caucasians. More case–control studies are needed to strengthen our conclusions and to assess the gene–gene and gene–environment interactions between ACE rs4646994 polymorphism and DCM/HCM.
Hygiene neu verstehen: Teil 3
Authors: Handke Denis Maximilian 
Published: November 2021

SummaryDer Hygieneplan sollte regelmäßig überprüft werden, wobei Überprüfungszyklen der unterschiedlichen Elemente zum Teil vorgegeben sind und teilweise Empfehlungen vorliegen. Bestehende Hygienevorkehrungen sollten im Rahmen regelmäßiger Überprüfungen infrage gestellt werden, um beispielsweise nicht notwendige Prozesse zu ermitteln und mit diesen aufzuhören. Bei der Aktualisierung des Hygieneplans sollte nicht nur das Dokument an sich geprüft werden, sondern auch alle Dokumente, die mit den verschiedenen Aspekten zusammenhängen.
Geld stinkt nicht
Authors: Bierbach Elvira 
Published: November 2021

SummaryVermögensaufbau ist nicht nur etwas für Menschen, die viel verdienen. Auch zum Beispiel mit 50 € monatlich lässt sich mit dem systematischen Aufbau von Vermögen beginnen. Aus Erfahrung der Autorin scheuen sich viele Heilpraktikerinnen eher davor, sich mit finanziellen Fragen wie Honorarhöhe zu beschäftigen. Die Autorin möchte bei den DHZ-Leserinnen das Gegenteil erreichen. Neben leicht umsetzbaren Tipps in 10 Schritten, zum Beispiel für den Kassensturz oder die Wahl der richtigen Anlageform, liefert der Beitrag eine Liste mit Büchern und Links für das Selbststudium zum Thema Finanzen.
Proteomics in Thrombosis and Hemostasis
Authors: Letunica Natasha , Van Den Helm Suelyn , McCafferty Conor , Swaney Ella , Cai Tengyi , Attard Chantal , Karlaftis Vasiliki , Monagle Paul , Ignjatovic Vera 
Published: November 2021

AbstractProteomics, the simultaneous study of all proteins in a given cell, tissue or organism, is an innovative approach used to identify novel markers for diagnosis, prognosis and the pathophysiological mechanisms associated with diseases. Proteomic methodologies have been used in a variety of contexts such as investigating changes in protein abundance that may occur with disease presence, the response to therapeutic treatments as well as the impacts of age on the plasma proteome.Over the last decade, significant technological advancements in proteomic techniques have resulted in an increase in the use of proteomics in thrombosis and hemostasis research, particularly in order to identify relevant and novel clinical markers associated with bleeding and thrombosis. This mini-review explores the use of proteomics in the setting of thrombosis and hemostasis from 2010-2020, across five main domains (platelets, blood clot composition, stroke, venous thromboembolism, and therapeutics), as well as provides insights into key considerations for conducting proteomic studies.
Additive-manufactured single-piece thin multi-layer tungsten heater for an electrothermal thruster
Authors: Kinefuchi Kiyoshi , Nakata Daisuke , Coral Giulio , Suyalatu  , Sakai Hitoshi , Tsukizaki Ryudo , Nishiyama Kazutaka 
Published: November 2021

In this study, a novel single-piece thin multi-layer tungsten resistive heater was successfully fabricated using additive manufacturing and tested as an electrothermal thruster. The heater has 12 resistive layers, with each layer having a thickness and height of 0.15 and 81 mm, respectively, and can provide high heating efficiency. A single-piece or monolithic heater was manufactured via additive manufacturing technique, which drastically improved its reliability and decreased its manufacturing cost. In the heating and thrust measurement tests that used nitrogen gas as a propellant, the heater reached a gas temperature of ∼2000 K at a 140-A heater current without experiencing any failure. The tungsten-heater resistance linearly increased with an increase in temperature due to the temperature dependence of tungsten’s resistivity. The specific impulse and thrust increased with the heater temperature in accordance with the theoretical prediction. Even including a voltage drop due to a contact resistance, the achieved heater efficiency reached 63% at a 100-A heater current even without a thermal insulation around the thruster. The heater efficiency decreased with an increase in the heater temperature due to heat loss to the surroundings. The heat-loss analysis indicated that both thermal conduction and radiation heat losses were crucial for improving the heater performance at a high-temperature operation of over 2000 K.
Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan
Authors: Endo Akira , Uchida Mitsuo , Hayashi Naoki , Liu Yang , Atkins Katherine E. , Kucharski Adam J. , Funk Sebastian 
Published: November 2021

SignificanceEmpirical evidence on detailed transmission patterns of influenza among students within and between classes and grades and how they are shaped by school population structure (e.g., class and school sizes) has been limited to date. We analyzed a detailed dataset of seasonal influenza incidence in 29 primary schools in Japan and found that the reproduction number at school did not show any clear association with the size or the number of classes. Our findings suggest that the interventions that only focus on reducing the number of students in class at any moment in time (e.g., reduced class sizes and staggered attendance) may not be as effective as measures that aim to reduce within-class risk (e.g., mask-wearing and vaccines).