bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Suhu dan Lama Penyimpanan terhadap Kadar Glukosa pada Nasi Putih
Authors: Purbowati Purbowati , Anugrah Riva Mustika 
Published: May 2021

This study aimed to understand the difference of glucose levels in electrical strored rice i.e. rice cooker and the glucose level of rice stored at room temperature at 0, 6, and 12 hours. This study used a completely randomized design (CRD) with 2 treatment groups (electrical stored rice and room temperature stored rice). Storage time is 0, 6, and 12 hours. Each treatment was conducted with 3 repetitions. The glucose levels were measured using spectrophotometry method. The Kruskal Wallis test was used to analyze the glucose level difference of 2 treatment groups. The glucose level electrical stored rice at 6, and 12 hours storage were 3,31%, and 2,16% consecutively. Whereas the glucose level room temperature stored rice at 6 and 12 hours storage were 2,60% and 2,16% respectively. Bivariate analysis showed that there were significant differences of the glucose levels at 6 hours storage, however there was no significant difference at 12 hours storage. There was a massive decrease of the glucose levels during storage for both of the treatment groups. Tujuan penelitian ini untuk mengetahui perbedaan kadar glukosa nasi yang disimpan di rice cooker dan nasi yang disimpan pada suhu ruang dengan waktu simpan selama 0, 6, dan 12 jam. Penelitian ini menggunakan desain rancangan acak lengkap (RAL) dengan 2 kelompok perlakuan (nasi yang disimpan di dalam rice cooker dan nasi yang disimpan pada suhu ruang). Variabel waktu penyimpanan adalah 0, 6, dan 12 jam. Masing-masing pengujian dilakukan dengan 3 kali pengulangan. Kadar glukosa diukur menggunakan metode spektrofotometri. Uji Kruskal Wallis digunakan untuk menganalisa perbedaan kadar glukosa nasi yang disimpan di dalam rice cooker dan nasi yang disimpan pada suhu ruang. Kadar glukosa nasi yang disimpan di rice cooker pada penyimpanan selama 6 dan 12 jam yaitu berturut-turut 3,31 %, dan 2,16 %. Sedangkan kadar glukosa nasi yang disimpan pada suhu ruang selama 6 dan 12 jam adalah 2,60 % dan 2,16 %. Analisis bivariat menunjukkan adanya perbedaan kadar glukosa pada nasi yang disimpan di dalam rice cooker dan nasi yang disimpan pada suhu ruang pada penyimpanan selama 6 jam, tetapi tidak ada perbedaan kadar glukosa yang signifikan pada penyimpanan selama 12 jam. Terjadi penurunan kadar glukosa pada nasi selama penyimpanan, baik yang disimpan di dalam rice cooker maupun pada di suhu ruang.
Rasio Lingkar Pinggang-Pinggul dan Kaitannya dengan Kadar Kolesterol Total pada Wanita Dewasa
Authors: Nurohmi Susi , Marfu'ah Nurul , Naufalina Mira Dian , Farhana Siti Awalisanah Hani , Riza Muhammad El 
Published: May 2021

This study aimed to analyze the association between anthropometric assessments and total cholesterol levels among adult women. The research design was cross sectional study with purposive sampling methode involving 92 adult women in Sambirejo village, Mantingan, Ngawi, East Java. Anthropometric assessments consisted of BMI, waist circumference, and waist-hip ratio. Data analysis consisted of univariate and bivariate using Pearson Product Moment. Bivariate analysis was performed by the correlation of anthropometric assessment with total cholesterol levels. The results showed that 15.2% subjects were overweight and 54.1% subjects had obesity. There were 80,4 % subjects had waist circumference 80 cm and 71,7% subjects had waist-hip ratio ≥0,85. Subjects with cholesterol levels 200 mg / dL were 31,5 %. The BMI and waist circumference had no correlation to total cholesterol level. The waist-hip ratio had a significant correlation to cholesterol level. The conclusion of this study was waist-hip ratio in women related to high total cholesterol level.Penelitian ini bertujuan menganalisis hubungan penilaian antropometri dengan kadar kolesterol total pada wanita dewasa. Desain penelitian adalah studi potong lintang dengan melibatkan sebanyak 92 orang wanita dewasa. Sampel dipilih secara purposive sampling di desa Sambirejo Kecamatan Mantingan Kabupaten Ngawi Jawa Timur. Penilaian antropometri yang dilakukan meliputi IMT, lingkar pinggang dan rasio lingkar pinggang-pinggul. Analisis data terdiri atas univariat dan bivariat melalui uji Pearson Product Moment untuk melihat korelasi hasil penilaian antropometri dengan kadar kolesterol total. Hasil penelitian menunjukkan bahwa 15,2% dan 54,1% subjek memiliki status gizi lebih dan obesitas. Sebanyak 80,4 % memiliki lingkar pinggang 80 cm dan sebanyak 71,7% memiliki rasio lingkar pinggang dan pinggul ≥0,85. Subjek dengan kadar kolesterol 200 mg/dL sebanyak 31,5%. Hasil penelitian menunjukkan bahwa IMT dan lingkar pinggang tidak berkaitan dengan kadar kolesterol total. Rasio lingkar pinggang-pinggul berhubungan signifikan (p-value=0,29; r=0,227) dengan kadar kolesterol. Kesimpulan dari penelitian ini adalah rasio lingkar pinggang-pinggul pada wanita berkaitan dengan tingginya kadar kolesterol total.
Cytotoxicity and Target Modulation in Pediatric Solid Tumors by the Proteasome Inhibitor Carfilzomib
Authors: Thakur Satbir , Ruan Yibing , Jayanthan Aarthi , Boklan Jessica , Narendran Aru 
Published: May 2021

Background:
Most children with recurrent metastatic solid tumors have high mortality
rates. Recent studies have shown that proteasome inhibition leads to effective tumor killing in cells
that have acquired treatment resistance and metastatic properties.

Objective:
The purpose of this study was to test the potential of Carfilzomib (CFZ), a proteasome
inhibitor, in refractory pediatric solid tumors which is currently unknown.

Methods:
A panel of pediatric solid tumor cell lines, including neuroblastoma, Ewing’s sarcoma,
osteosarcoma, rhabdomyosarcoma and atypical teratoid rhabdoid tumor (ATRT), was used to evaluate
the cytotoxic and proteasomal inhibitory effects of CFZ. A drug scheduling experiment was performed
to determine the optimal dose and time to obtain effective cell killing. Combination studies
of CFZ with chemotherapeutic drugs of different classes were performed to determine the extent of
synergy.

Results:
CFZ showed effective cytotoxicity against all cell lines tested (mean IC50 = 7nM, range =
1-20nM) and activity in a fluorophore-tagged cell-based proteasome assay. Drug scheduling experiments
showed that the minimum exposure of 4-8 hours/day is needed for effective cumulative
killing. CFZ, when combined with chemotherapeutic drugs of different classes, synergistically enhanced
the extent of cell death.

Conclusions:
CFZ showed cytotoxic activity against all the solid pediatric cancer cell lines tested.
This study provides initial in vitro data on the potential of CFZ to treat pediatric solid tumors and
supports further investigations into the components of drug scheduling, biological correlates and
drug combinations for future early phase clinical trials in children.
Method Development and Validation of a Novel UHPLC Coupled with
MS/MS System for the Estimation of Brivaracetam in Human (K2EDTA)
Plasma Samples and its Application to Pharmacokinetic Study
Authors: Aalapati Kiran Kumar , Singh Amit , Patnaik Ranjana S. 
Published: May 2021

Background:
Brivaracetam is a novel antiepileptic drug clinically approved for the treatment
of partial onset seizures in adults and adolescents. It has some abuse potential and assigns to
Schedule V category under the Controlled Substance Act by the Drug Enforcement Administration.
It is essential to develop a faster, simple, and highly sensitive method for the quantification of
Brivaracetam in human plasma by employing simple liquid-liquid extraction.

Objective:
The objective of this study is to develop and validate a novel UHPLC-MS/MS method
for the estimation of brivaracetam in human plasma samples and application to pharmacokinetic
study.

Methods:
An ultra-high-pressure liquid chromatography-tandem mass spectrometry method was
developed and validated according to current regulatory guidelines for bioanalytical methods. Sample
processing (50 μL) involved only a simple liquid-liquid extraction by ethyl acetate as extraction
solvent. Brivaracetam-d7 was used as an internal standard. The chromatographic analysis was
performed by a Unisol C18 (4.6 X 100 mm, 5μm) column using 0.1% formic acid in water/acetonitrile
(20/80 V/V) as an isocratic mobile phase, at a flow rate of 1.0 mL/min with a run time of 2.2
min. Brivaracetam and its internal standard Brivaracetam D7 were detected and quantified in positive
ion mode using multiple reaction monitoring transitions at m/z 213.100→168.100 and m/z
220.000→175.100, respectively. The developed method was applied to assess pharmacokinetic parameters
like Cmax, Tmax, t1/2 and AUC for Brivaracetam in healthy, male, and adult humans.

Results:
The method was validated over a concentration range of 20.000 ng/mL to 4000. 000
ng/mL. Both intra- and inter-assay precision and accuracy were <15% for all quality control samples.
No matrix effect was observed. Pharmacokinetic results showed that test formulation is bioequivalent
with reference formulation.

Conclusion:
The present assay is faster, highly sensitive and simpler than previously published analytical
reports for brivaracetam in human plasma samples and is suitable for pharmacokinetic evaluation
of any marketed formulation.
Guided Relaxation–Based Virtual Reality for Acute Postoperative Pain and Anxiety in a Pediatric Population: Pilot Observational Study
Authors: Olbrecht Vanessa A , O'Conor Keith T , Williams Sara E , Boehmer Chloe O , Marchant Gilbert W , Glynn Susan M , Geisler Kristie J , Ding Lili , Yang Gang , King Christopher D 
Published: May 2021

Background
Distraction-based therapies, such as virtual reality (VR), have been used to reduce pain during acutely painful procedures. However, distraction alone cannot produce prolonged pain reduction to manage sustained postoperative pain. Therefore, the integration of VR with other pain-reducing therapies, like guided relaxation, may enhance its clinical impact.

Objective
The goal of this pilot study was to assess the impact of a single guided relaxation–based VR (VR-GR) session on postoperative pain and anxiety reduction in children. We also explored the influence of pain catastrophizing and anxiety sensitivity on this association.

Methods
A total of 51 children and adolescents (7-21 years) with postoperative pain and followed by the Acute Pain Service at Cincinnati Children’s Hospital were recruited over an 8-month period to undergo a single VR-GR session. Prior to VR, the patients completed 2 questionnaires: Pain Catastrophizing Scale for Children (PCS-C) and the Child Anxiety Sensitivity Index (CASI). The primary outcome was a change in pain intensity following the VR-GR session (immediately, 15 minutes, and 30 minutes). The secondary outcomes included changes in pain unpleasantness and anxiety.

Results
The VR-GR decreased pain intensity immediately (P<.001) and at 30 minutes (P=.04) after the VR session, but not at 15 minutes (P=.16) postsession. Reductions in pain unpleasantness were observed at all time intervals (P<.001 at all intervals). Anxiety was reduced immediately (P=.02) but not at 15 minutes (P=.08) or 30 minutes (P=.30) following VR-GR. Patients with higher CASI scores reported greater reductions in pain intensity (P=.04) and unpleasantness (P=.01) following VR-GR. Pain catastrophizing was not associated with changes in pain and anxiety.

Conclusions
A single, short VR-GR session showed transient reductions in pain intensity, pain unpleasantness, and anxiety in children and adolescents with acute postoperative pain. The results call for a future randomized controlled trial to assess the efficacy of VR-GR.

Trial Registration
ClinicalTrials.gov NCT04556747; https://clinicaltrials.gov/ct2/show/NCT04556747
Fathers’ Involvement in Parenting and Intimacy towards Husbands
Authors: Savitri Hidayati Diana , Sari Christal Nandya Deby Mayang 
Published: May 2021

Each marriage must have a problem, no exception to the newly married couple. Individuals who have intimacy in their marriage will be easier to deal with the conflicts that occur with their partner. One of the things that allegedly caused women's difficulties to bring intimacy to her husband was the woman's relationship with past experiences that were closely related to parental care, especially dad. The purpose of this research is to know the relationship of father involvement in parenting with intimacy to husbands. The research design used is quantitative correlational. The Instrument for measuring both variables in the study uses the father's involvement scale in parenting and the intimacy scale. The research location is in a sub-district in Malang Regency with the number of subjects 99 wife and sampling techniques using purposive sampling. The research subject criteria are: aged between 18- 25 years old, taken care of by father until 18 years old, not going through long distance relationship with her husband, minimum 1 year marriage and minimum number of children is one person. Data analysis using product moment. The results showed that there was a significant positive relationship between the involvement of the father in the care of intimacy against the husband with the value of coefficiencies R = 0.397, with significance p = 0.000 < 0.05.
Adgangen til å ivareta sideformål som arbeidsforhold og sosiale forhold etter anskaffelsesreglene
Authors: Goller Morten , Ekre Oda H. , Gulbrandsen Beate 
Published: May 2021

It follows from the Norwegian Procurement Act section 5 that contracting authorities shall take appropriate measures to ensure that public contracts are performed in accordance with horizontal policies such as social rights and labour rights. The article analyses the scope for contracting authorities’ possibility to set out such requirements pursuant to the public procurement rules, with particular emphasis on contractual requirements.
The article also analyses three typical examples of such contract provisions, i.e. requirements for the use of apprentices, requirements for the use of permanent employees and the use of subcontractors.
Pursuant to the applicable sources of law, the contracting authorities have a broad discretion to set out contract provisions regarding social and labour rights. Such provisions must however be linked to the subject matter of the contract. This implies that the provisions must relate to the work undertaken for the specific contract. The provisions cannot relate to the supplier’s general business operation. The requirements must also comply with the fundamental principles set out in the Norwegian Procurement Act section 4.
A Mixed Boundary Value Problem for the Laplace Equation in a semi-infinite Layer
Authors: Algazin O. D. , Kopaev A. V. 
Published: May 2021

The paper offers a solution of the mixed Dirichlet-Neumann and Dirichlet-Neumann-Robin boundary value problems for the Laplace equation in the semi-infinite layer, using the previously obtained solution of the mixed Dirichlet-Neumann boundary value problem for a layer.The functions on the right-hand sides of the boundary conditions are considered to be functions of slow growth, in particular, polynomials. The solution to boundary value problems is also sought in the class of functions of slow growth. Continuing the functions on the right-hand sides of the boundary conditions on the upper and lower sides of the semi-infinite layer from the semi-hyperplane to the entire hyperplane, we obtain the Dirichlet-Neumann problem for the layer, the solution of which is known and written in the form of a convolution. If the right-hand sides of the boundary conditions are polynomials, then the solution is also a polynomial. To the solution obtained it is necessary to add the solution of the problem for a semi-infinite layer with homogeneous boundary conditions on the upper and lower sides and with an inhomogeneous boundary condition of Dirichlet, Neumann or Robin on the lateral side. This solution is written as a series. If we take a finite segment of the series, then we obtain a solution that exactly satisfies the Laplace equation and the boundary conditions on the upper and lower sides of the semi-infinite layer and approximately satisfies the boundary condition on the lateral side.An example of solving the Dirichlet-Neumann and Dirichlet-Neumann-Robin problems is considered, describing the temperature field of a semi-infinite plate the upper side of which is heat-isolated, on the lower side the temperature is set in the form of a polynomial, and the lateral side is either heat-isolated, or holds a zero temperature, or has heat exchange with a zero-temperature environment. For the first two Dirichlet-Neumann problems, the solution is obtained in the form of polynomials. For the third Dirichlet-Neumann-Robin problem, the solution is obtained as a sum of a polynomial and a series. If in this solution the series is replaced by a finite segment, then an approximate solution of the problem will be obtained, which approximately satisfies the Robin condition on the lateral side of the semi-infinite layer.
On a Space-Fractional Generalization of the Black Oil Model
Authors: Belevtsov N. S. 
Published: May 2021

Classical multiphase filtration models, which are based on Darcy's law, are well studied and actively used in modern oil engineering. However, such models do not allow efficient describing of processes with power-law memory effects or with spatial non-locality effects. In recent years, there has been a significantly increasing interest in models with fractional derivatives and integrals that allow such effects to be taken into account.The article considers the space-fractional generalization of the two-phase Black Oil model. This model is built on the basis of a fractional modification of the Darcy’s law with the Riesz potential, which is one of the possible generalizations of a fractional integral to the case of a multidimensional space. The use of such a modification of Darcy's law allows efficient describing of filtration processes in heterogeneous fractured porous media with the effects of spatial non-locality.For the numerical solution of the system of equations from the obtained model, the use of the IMPES method is proposed. For this purpose, from the presented system of equations, one equation is selected that describes the evolution of pressure. This equation is written provided that the capillary pressure variation within the time step is neglected.A special case of the pressure equation with the Riesz potential of radial function is considered, which describes the pressure variation in the case of a radial plane flow. For this equation, a self-similar solution is constructed using the Mellin integral transform method. A representation of this solution in the form of the Mellin-Barnes contour integral was obtained, which made it possible to write it in terms of the Fox functions. It is shown that in the limiting case of a zero degree of the Riesz potential, this solution coincides with the self-similar solution of the classical heat equation. The constructed self-similar solution can be further used in the software implementation of the numerical solution of the model presentedThe main line of further research is to develop and implement a software computing system based on the proposed fractional generalization of the two-phase Black Oil model.
Boolean Functions with Affine Annihilators
Authors: Zelenetsky A. S. , Klyucharev P. G. 
Published: May 2021

In the article we study boolean functions with affine annihilators. We have obtained results in both, estimating the number of functions under study and defining the relationship between Walsh-Hadamard coefficients of an arbitrary boolean function and its affine annihilator available. The second section of this article focuses on estimating the number of boolean functions with affine annihilators. The value has top and bottom bound. Besides, we have obtained the asymptotic estimate of the number of boolean functions with affine annihilators. The third section studies the Walsh-Hadamard coefficients of boolean functions with affine annihilators. First, we have derived the dependence of the Walsh-Hadamard coefficient on the distance between an arbitrary boolean function and a vector space of the affine function’s annihilators. Based on this result, we have obtained the dependence of distance between an arbitrary boolean function and a set of functions with affine annihilators on the spectrum of given function. Also we have defined the necessary and sufficient condition for the arbitrary boolean function to be with an affine annihilator available. Using the results obtained we bounded an absolute value of Walsh-Hadamard coefficients.Also we suggested a method for boolean equations analysis, which is based on two known methods. Namely, we used an analysis using annihilators and an analysis using linear analogs. We have obtained an estimate of the success probability of the suggested method for an arbitrary boolean function. Also we proved that bent functions are the most resistant to this analysis.The results obtained can be used in analysis of boolean equations. Also obtained dependences can be used, for instance, to study bent functions and algebraic immunity of boolean functions.
Necropolitics and the violence of Indigenous incarceration
Authors: Broadfield Kirstie , Dawes Glenn , Chong Mark David 
Published: May 2021

Since the Royal Commission into Aboriginal Deaths in Custody, over thirty years ago, there have been over 400 Indigenous deaths in custody, with 28% of the Australian prison population identifying as Indigenous. Indigenous over-representation in the criminal justice system continues to be an unresolved issue despite varying attempts to reduce the high incidence of incarceration experienced by Indigenous Australians. This paper proposes a fresh approach to analysing the violence of Indigenous incarceration using the theory of necropolitics. The paper represents a critical discussion of a work-in-progress of how an analytical framework based on necropolitics has the potential to elevate the often-silenced voices of vulnerable populations, such as Indigenous Australians, within the criminal justice system. This is because the proposed study will present a multi-level analysis of the overt and covert forms of violence perpetrated against Indigenous Australians within the criminal justice system and unlock the potential of exposing the extent to which unequal relations of power contribute to these forms of violence. The significance of this research therefore lies in its capacity to provide policymakers with deeper insights into how such forms of violence impact upon and further disempower Indigenous Australians in the Australian criminal justice system.