bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multiwavelength study of star formation in 15 local star-forming galaxies
Authors: Smith Madison V , van Zee L , Salim S , Dale D , Staudaher S , Wrock T , Maben A 
Published: May 2021

ABSTRACT
We have fit the far-ultraviolet to mid-infrared spectral energy distributions (SEDs) for several nearby galaxies (&lt;20 Mpc). Global, radial, and local photometric measurements are explored to better understand how SED-derived star formation histories (SFHs) and classic star formation rate tracers manifest at different scales. Surface brightness profiles and radial SED fitting provide insight into stellar population gradients in stellar discs and haloes. A double exponential SFH model is used in the SED fitting to better understand the distributions of young versus old populations throughout these galaxies. Different regions of a galaxy often have undergone very different SFHs, either in strength, rate, timing, or some combination of all these factors. An analysis of individual stellar complexes within these galaxies shows a relationship between the ages of stellar clusters and how these clusters are distributed throughout the galaxy. These star formation properties are presented alongside previously published H i observations to provide a holistic picture of a small sample of nearby star-forming galaxies. The results presented here show that there is a wide variety of star formation gradients and average stellar age distributions that can manifest in a ΛCDM universe.
Multiwavelength detectability of isolated black holes in the Milky Way
Authors: Scarcella Francesca , Gaggero Daniele , Connors Riley , Manshanden Julien , Ricotti Massimo , Bertone Gianfranco 
Published: May 2021

ABSTRACT
Isolated black holes in our Galaxy have eluded detection so far. We present here a comprehensive study on the detectability of isolated stellar-mass astrophysical black holes that accrete interstellar gas from molecular clouds in both the local region and the Central Molecular Zone. We adopt a state-of-the-art model for the accretion physics backed up by numerical simulations, and study the number of observable sources in both the radio and X-ray band, as a function of a variety of parameters. We discuss in particular the impact of the astrophysical uncertainties on our prediction for the number of bright X-ray sources in the central region of the Galaxy. We finally consider future developments in the radio domain and assess the potential of SKA to detect a population of astrophysical black holes accreting gas in our Galaxy.
Association of renal impairment with cognitive dysfunction in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)
Authors: Paterson Euan N , Maxwell Alexander P , Kee Frank , Cruise Sharon , Young Ian S , McGuinness Bernadette , McKay Gareth J 
Published: May 2021

Abstract

Introduction
Chronic kidney disease (CKD) is a recognized risk factor for cognitive impairment. Identification of those at greatest risk of cognitive impairment may facilitate earlier therapeutic intervention. This study evaluated associations between estimated glomerular filtration rate (eGFR) and cognitive function in the Northern Ireland Cohort for the Longitudinal Study of Ageing.

Methods
Data were available for 3412 participants ≥50 years of age living in non-institutionalized settings who attended a health assessment between February 2014 and March 2016. Measures of serum creatinine (SCr) and cystatin C (cys-C) were used for eGFR. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE).

Results
Following adjustment for potential confounders, a single unit decrease in eGFR was significantly associated with reduced cognitive function defined by an MMSE ≤24/30 {eGFR calculated using serum cys-C [eGFRcys]: β = −0.01 [95% confidence interval (CI) −0.001 to −0.01], P = 0.01} and MoCA &lt;26/30 [β = −0.01 (95% CI −0.002 to −0.02), P = 0.02]. Similarly, CKD Stages 3–5 were also associated with a moderate increase in the odds of cognitive impairment (MMSE ≤24) following adjustment for confounders [eGFRcys: odds ratio 2.73 (95% CI 1.38–5.42), P = 0.004].

Conclusions
Decreased eGFRcys was associated with a significantly increased risk of cognitive impairment in a population-based cohort of older adults. However, there was no evidence of an association between cognitive impairment and the more commonly used eGFR calculated using SCr. eGFRcys may offer improved sensitivity over eGFRcr in the determination of renal function and associated risk of cognitive impairment.
The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism
Authors: Le Xuyen H. , Lee Chun-Pong , Millar A. Harvey 
Published: May 2021

AbstractMalate oxidation by plant mitochondria enables the generation of both oxaloacetate and pyruvate for tricarboxylic acid (TCA) cycle function, potentially eliminating the need for pyruvate transport into mitochondria in plants. Here, we show that the absence of the mitochondrial pyruvate carrier 1 (MPC1) causes the co-commitment loss of its putative orthologs, MPC3/MPC4, and eliminates pyruvate transport into Arabidopsis thaliana mitochondria, proving it is essential for MPC complex function. While the loss of either MPC or mitochondrial pyruvate-generating NAD-malic enzyme (NAD-ME) did not cause vegetative phenotypes, the lack of both reduced plant growth and caused an increase in cellular pyruvate levels, indicating a block in respiratory metabolism, and elevated the levels of branched-chain amino acids at night, a sign of alterative substrate provision for respiration. 13C-pyruvate feeding of leaves lacking MPC showed metabolic homeostasis was largely maintained except for alanine and glutamate, indicating that transamination contributes to the restoration of the metabolic network to an operating equilibrium by delivering pyruvate independently of MPC into the matrix. Inhibition of alanine aminotransferases when MPC1 is absent resulted in extremely retarded phenotypes in Arabidopsis, suggesting all pyruvate-supplying enzymes work synergistically to support the TCA cycle for sustained plant growth.
A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control
Authors: Ojeda Valle , Jiménez-López Julia , Romero-Campero Francisco José , Cejudo Francisco Javier , Pérez-Ruiz Juan Manuel 
Published: May 2021

Abstract
In chloroplasts, thiol-dependent redox regulation is linked to light since the disulfide reductase activity of thioredoxins (Trxs) relies on photo-reduced ferredoxin (Fdx). Furthermore, chloroplasts harbor an NADPH-dependent Trx reductase (NTR) with a joint Trx domain, termed NTRC. The activity of these two redox systems is integrated by the redox balance of 2-Cys peroxiredoxin (Prx), which is controlled by NTRC. However, NTRC was proposed to participate in redox regulation of additional targets, prompting inquiry into whether the function of NTRC depends on its capacity to maintain the redox balance of 2-Cys Prxs or by direct redox interaction with chloroplast enzymes. To answer this, we studied the functional relationship of NTRC and 2-Cys Prxs by a comparative analysis of the triple Arabidopsis (Arabidopsis thaliana) mutant, ntrc-2cpab, which lacks NTRC and 2-Cys Prxs, and the double mutant 2cpab, which lacks 2-Cys Prxs. These mutants exhibit almost indistinguishable phenotypes: in growth rate, photosynthesis performance, and redox regulation of chloroplast enzymes in response to light and darkness. These results suggest that the most relevant function of NTRC is in controlling the redox balance of 2-Cys Prxs. A comparative transcriptomics analysis confirmed the phenotypic similarity of the two mutants and suggested that the NTRC-2-Cys Prxs system participates in cytosolic protein quality control. We propose that NTRC and 2-Cys Prxs constitute a redox relay, exclusive to photosynthetic organisms that fine-tunes the redox state of chloroplast enzymes in response to light and affects transduction pathways towards the cytosol.
Short-term Momentum
Authors: Medhat Mamdouh , Schmeling Maik 
Published: May 2021

Abstract
We document a striking pattern in U.S. and international stock returns: double sorting on the previous month’s return and share turnover reveals significant short-term reversal among low-turnover stocks, whereas high-turnover stocks exhibit short-term momentum. Short-term momentum is as profitable and as persistent as conventional price momentum. It survives transaction costs and is strongest among the largest, most liquid, and most extensively covered stocks. Our results are difficult to reconcile with models imposing strict rationality but are suggestive of an explanation based on some traders underappreciating the information conveyed by prices.
Investigating In Vitro Mating Preference Between or Within the Two Forms of Pyrenophora teres and Its Hybrids
Authors: Dahanayaka Buddhika A. , Vaghefi Niloofar , Snyman Lislé , Martin Anke 
Published: May 2021

Net blotch diseases result in significant yield losses to barley industries worldwide. They occur as net-form and spot-form net blotch caused by Pyrenophora teres f. teres and P. teres f. maculata, respectively. Hybridization between the forms was proposed to be rare, but recent identifications of field hybrids has renewed interest in the frequency and mechanisms underlying hybridization. This study investigates the mating preference of P. teres f. teres, P. teres f. maculata, and laboratory-produced hybrids in vitro, using 24 different isolates and four different experimental setups. Two crosses in our study produced ascospores during two intervals separated by a 32- to 35-day period of no ascospore production. For these crosses, P. teres f. teres isolates mated with isolates of the same form during the early ascospore production interval, and produced hybrids during the later interval. P. teres f. maculata isolates did not mate with isolates of the same form, but instead hybridized with P. teres f. teres isolates. Analyses based on DArTseq markers confirmed that laboratory-produced hybrids, when given the choice to mate with both P. teres f. teres and P. teres f. maculata, mated with P. teres f. teres isolates. These results unravel a novel concept that P. teres f. teres seems to have a greater reproduction vigor than P. teres f. maculata, which could lead to increased prevalence of hybrid incidences in vivo.
Managing toxicities associated with immune checkpoint inhibitors
Authors: Park Jiyeon Joy , Arafath Syed , Kumar Samir T. , Sharma Roopali , Dixit Deepali 
Published: May 2021

ABSTRACT
Recent development of immunotherapy has led to remarkable advancement in cancer therapy. Drugs that inhibit the cytotoxic T-lymphocyte-associated protein (CTLA-4) and programmed death-1 (PD-1) immune checkpoint pathways have shown improved patient survival. However, by altering the immune response to fight cancer, a new class of adverse reactions has emerged, known as immune-related adverse events. These adverse events are due to overactivation of the immune system in almost any organ of the body, can occur at any point in a patient's treatment course, and may become life-threatening. This article describes how to promptly recognize and manage these toxicities.
Recognizing and treating endometriosis
Authors: Blamble Tiffany , Dickerson Lisa 
Published: May 2021

ABSTRACT
Endometriosis, defined as endometrium-like tissue located outside the uterine cavity, is a chronic and frequently painful disease that affects about 10% of reproductive-aged women worldwide. The ectopic endometrial tissue, which is still hormonally responsive, generates a chronic inflammatory state resulting in an array of sometimes debilitating symptoms as well as subfertility. Despite its prevalence and significant effect on a woman's health and quality of life, receiving a diagnosis of endometriosis often takes years. This article reviews the epidemiology, pathophysiology, clinical presentation, and treatment options for managing endometriosis in women who do not desire pregnancy and in those who do, and includes information on the newest treatment option, the oral gonadotropin-releasing hormone (GnRH) antagonist elagolix.
Retention and change in PAs' first years of employment
Authors: Quella Alicia K. , Hooker Roderick S. , Zobitz John M. 
Published: May 2021

ABSTRACT

Objective:
Employment analyses demonstrate that physician assistants (PAs) exhibit role flexibility in US medicine. The next step in understanding this labor-shifting observation is to know at what career stage it first occurs.

Methods:
Using matriculate data linked to the American Academy of PAs (AAPA) census survey data, a longitudinal analysis of seven graduate cohorts revealed that one-third of PAs changed specialty roles at least once during their first decade of employment.

Results:
From this series, it appears that new PAs spend about 3.4 years in their first job, on average, before they decide to move to another medical or surgical field. In examining PAs who changed their clinical role during this time period, 28% shifted from primary care to another medical or specialty role. Overall, the PA career movement to nonprimary care specialties increased substantially.

Conclusions:
These findings support observations that PAs provide an adaptive role in a dynamic and changing medical workforce.
Cognitive-behavior therapy for sleep disorders at midlife
Authors: Nowakowski Sara , Meers Jessica M. 
Published: May 2021

Abstract
Insomnia is a clinical disorder characterized as difficulty falling asleep, staying asleep, or waking too early. To meet diagnostic criteria for an insomnia disorder, these difficulties must be present for a minimum of 3 months and cause significant daytime impairment. Insomnia is common in women transitioning through menopause and frequently continues in the years after menopause. Cognitive-behavior therapy for insomnia (CBT-I) is a brief behavior treatment, with decades of evidence supporting its effectiveness across the adult lifespan, including midlife. This Practice Pearl highlights the rationale for CBT-I and describes treatment components, with specific considerations for its use in midlife women.
Weight regulation in menopause
Authors: Knight Michael G. , Anekwe Chika , Washington Krystilyn , Akam Eftitan Y. , Wang Emily , Stanford Fatima Cody 
Published: May 2021

Abstract

Importance and Objective:
Obesity is a chronic disease of epidemic proportions that continues to affect millions of Americans each year. Postmenopausal women are particularly affected by obesity and have higher rates of severe obesity when compared with their male counterparts. The prevalence of obesity in this population is linked to increased morbidity and mortality and promotes the development and progression of numerous obesity-related health conditions. This review examines the epidemiology, pathophysiology, clinical assessment, and treatment of postmenopausal women with obesity.

Methods:
We have reviewed relevant and up-to-date literature in the MEDLINE database to represent the current understanding of obesity and its effects in this patient population. Articles published between the years 2000 and 2020 were selected for review to represent the most up-to-date evidence on the topic. Search terms used in the PubMed search included women, obesity, menopause, aging, mid-age women, metabolism, weight gain, treatment of obesity, weight loss, bariatric surgery, weight loss medications, diet, physical activity, and behavior modification.

Discussion and Conclusion:
Obesity is a complex, chronic, relapsing disease that requires comprehensive assessment and treatment. Obesity is linked to hormonal, lifestyle, and environmental changes that occur during the menopausal transition, and it increases the risk for cardiometabolic disease. The utilization of appropriate clinical evaluation methods to identify obesity in postmenopausal women, and the implementation of effective lifestyle, pharmacotherapeutic, and surgical interventions, have the propensity to reduce the deleterious effects of obesity in this population.

Video Summary:

http://links.lww.com/MENO/A770.
Functional Properties of a Purified Reconstituted Bilayer Matrix Design Support Natural Wound Healing Activities
Authors: Armstrong David G. , Orgill Dennis P. , Galiano Robert D. , Glat Paul , Kaufman Jarrod , Mehr Marco , Zelen Charles M. 
Published: May 2021

Background:
Biomaterial engineering has produced numerous matrices for use in tissue repair, utilizing various materials and processing methods, which can impact the ability of the products to encourage wound healing. Recently, we observed favorable clinical outcomes, using a novel purified reconstituted bilayer matrix (PRBM; Geistlich Derma-Gide) to treat chronic diabetic foot ulcers.

Methods:
Evaluations of the structural and functional characteristics of PRBM in vitro were performed to assess how this biomaterial may affect the favorable clinical results observed by influencing the wound environment and key physiologic mechanisms necessary for the healing process. Investigations included scanning electron microscopy, cell culture analyses, gene expression assays, matrix metalloproteinase activity assessment, and pH measurement.

Results:
Cross-sectional scanning electron microscopy demonstrated a distinct bilayer structure with porous and compact layers. The PRBM structure allowed cell types involved in wound healing to bind and proliferate. Expression analysis of growth factor-responsive genes demonstrated binding and preservation of bioactive growth factors TGF-β1, bFGF, and VEGF by PRBM. Boyden chamber migration assays revealed increased cellular migration compared with controls. In the presence of PRBM, the activity of MMP-1, MMP-2, and MMP-9 was significantly lower compared with control samples. pH of the PRBM in solution was slightly acidic.

Conclusions:
Based on in vitro evaluations, it appears that the PRBM processing without deleterious chemical crosslinking results in a suitable ECM possessing characteristics to aid natural wound healing, including cell attachment, migration, proliferation, differentiation, and angiogenesis. These in vitro data support the promising healing rate observed clinically when chronic DFUs are treated with PRBM.
Diagnosing Common Deadly Infections in the Era of COVID-19
Authors: Zyablitskaya Mariya , Suarez Maria J. , Gupta Aanchal , Samaroo-Campbell Jevon , Nakeshbandi Mohamed , Chapnick Edward K. , Ghitan Monica 
Published: May 2021

Abstract
The COVID-19 pandemic has challenged clinicians to recognize COVID-19 as one of the diagnostic explanation for common presentations, including fever, cough, and shortness of breath. Latent tuberculosis is responsible for 80% of active tuberculosis cases in the United States, and presentation can vary from asymptomatic to disseminated disease. This potential diagnosis should be thoroughly investigated in foreign-born patients in US hospitals, regardless of travel history and presenting symptoms. We report a patient diagnosed with postpartum disseminated tuberculosis with hematogenous spread to the fetus.
Seasonal variation of peptic ulcer disease, peptic ulcer bleeding, and acute pancreatitis
Authors: Yoon Jin Young , Cha Jae Myung , Kim Ha Il , Kwak Min Seob 
Published: May 2021

Abstract
Although gastrointestinal diseases are reported at various times throughout the year, some particular seasons are associated with a higher incidence of these diseases. This study aimed to identify the seasonal variations of peptic ulcer (PU), peptic ulcer bleeding (PUB), and acute pancreatitis (AP) in South Korea.
We conducted a retrospective, observational cohort study of all subjects aged >18 years between 2012 and 2016 using the Health Insurance Review and Assessment-National Patient Samples database, previously converted to the standardized Observational Medical Outcomes Partnership-Common Data Model. We assessed the overall seasonal variations of PU, PUB, and AP and further analyzed seasonal variations according to age and sex subgroups.
In total, 14,626 patients with PU, 3575 with PUB, and 9023 with AP were analyzed for 5 years. A clear seasonal variation was noted in PU, with the highest incidence rate during winter, the second highest during spring, the third highest during summer, and the lowest incidence during autumn for 5 years (P < .001). PUB also showed significant seasonal fluctuations, with winter peak for 4 years, except 1 year, which had a spring peak (P < .001). However, AP showed no clear seasonal variations (P = .090). No significant differences in the seasonal variation of PU, PUB, and AP were observed according to sex and age subgroups (<60 years vs ≥60 years).
Seasonal variation of PU and PUB should be considered when determining allocation of available health care resources.
Effect of golimumab on health-related quality of life, other patient-reported outcomes and healthcare resource utilization in patients with moderate-to-severe ulcerative colitis: a real-world multicenter, noninterventional, observational study in Greece
Authors: Gatopoulou Anthia , Christodoulou Dimitrios K. , Katsanos Konstantinos H. , Bakos Dimitrios , Mouzas Ioannis , Tzouvala Maria , Theodoropoulou Angeliki , Paspatis Gregorios , Theocharis George , Thomopoulos Konstantinos , Giouleme Olga , Kourikou Anastasia , Manolakopoulos Spilios , Zampeli Evanthia , Michopoulos Spyros , Karatzas Pantelis , Katsaros Marios , Moschovis Dimitris , Orfanoudaki Eleni , Livieratos Achilleas , Petrikkou Evangelia , Mantzaris Gerassimos J. 
Published: May 2021

Background and aims
This real-world study assessed the impact of golimumab on health-related quality of life (HRQoL) and other patient-reported outcomes (PROs) in patients with ulcerative colitis over 12 months in Greece.

Methods
GO-LIFE was a noninterventional, prospective, multicenter, 12-month study. Patients who had moderately-to-severely active ulcerative colitis were naïve to antitumor necrosis factor (anti-TNFα) therapy and had failed previous conventional therapy. Patients received golimumab as per label. The primary endpoint was patients achieving inflammatory bowel disease questionnaire 32-item (IBDQ-32) remission at 12 months. Secondary endpoints, at 6 and 12 months, included patients achieving IBDQ-32 response; the mean change in the treatment satisfaction questionnaire for medication (TSQM) and the work productivity and activity impairment in ulcerative colitis (WPAI:UC) questionnaires; changes in healthcare utilization; patients achieving clinical response and remission; adherence rates and the percentage of patients who discontinued golimumab.

Results
IBDQ-32 remission was achieved by 76.9% of patients at 12 months. Mean changes in all TSQM and WPAI:UC domain scores at 12 months were statistically significant. Clinical remission was achieved by 49.4 and 50.6% of patients at 6 and 12 months, and clinical response by 59.3 and 56.8%, respectively. All patients but one (80/81) had high adherence (≥80%) to golimumab treatment over 12 months. Ulcerative colitis-related health care resource utilization was reduced during the follow-up period.

Conclusions
In real-world settings, treatment with golimumab resulted in meaningful improvements in HRQoL and other PROs, and in disease activity at 6 and 12 months in patients with moderately-to-severely active ulcerative colitis who were naïve to anti-TNFa therapy.