bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Smoking Cause Differences in Urine Microbiome in Male Patients With Bladder Cancer? A Retrospective Study
Authors: Ma Wenchao , Zhang Wentao , Shen Liliang , Liu Ji , Yang Fuhang , Maskey Niraj , Wang Hong , Zhang Junfeng , Yan Yang , Yao Xudong 
Published: June 2021

BackgroundTobacco smoking is a carcinogen for many cancers including bladder cancer. The microbiota is involved in the occurrence, development, and treatment of tumors. We explored the composition of male urinary microbiome and the correlation between tobacco smoking and microbiome in this study.MethodsAlpha diversity, principal component analysis (PCA) and Adonis analysis, linear discriminant analysis (LDA) coupled with effect size measurement, and PICRUSt function predictive analysis were used to compare different microbiome between smokers and non-smokers in men.ResultsThere were 26 qualified samples included in the study. Eleven of them are healthy controls, and the others are from men with bladder cancer. Simpson index and the result of PCA analysis between smokers and non-smokers were not different (P &gt; 0.05) in healthy men. However, the abundance of Bacteroidaceae, Erysipelotrichales, Lachnospiraceae, Bacteroides, and so on in the urinary tract of smokers is much higher than that of non-smokers. Compared to non-smokers, the alpha diversity in smokers was elevated in patients with bladder cancer (P &lt; 0.05). PCA analysis showed a significant difference between smokers and non-smokers (P &lt; 0.001), indicating that tobacco smoking plays a vital role in urinary tract microbial composition.ConclusionThe composition of microbiome in the urinary tract is closely related to tobacco smoking. This phenomenon is more significant in patients with bladder cancer. This indicates tobacco smoking may promote the occurrence and development of bladder cancer by changing urinary tract microbiome.
Optimal Duration of Neoadjuvant Taxane and Carboplatin Combined With Anti-HER2 Targeted Therapy for HER2-Positive Breast Cancer
Authors: Xie Yifan , Wu Siyu , Zhang Ying , Li Jianwei , Mo Miao , Shao Zhimin , Liu Guangyu 
Published: June 2021

BackgroundTaxane, carboplatin and trastuzumab (TCH) is an effective neoadjuvant regimen for human epidermal growth factor receptor 2 (HER2)-positive breast cancer with high pathologic complete response (pCR) rate. The KATHERINE trial changes the outlook for high-risk HER2-positive breast cancer, which suggests that escalation treatment for patients with residual disease after neoadjuvant anti-HER2 therapy may improve survival. The major objective of this study was to investigate the fewest cycles of neoadjuvant TCH therapy needed to screen out non-pCR patients.MethodsThis retrospective study included patients with HER2-positive breast cancer who received either four or six cycles of TCH preoperatively at Fudan University Shanghai Cancer Center between 2008 and 2019. The pCR status was evaluated, and relevant factors associated with pCR were identified using univariate and multivariable analyses. The pathological results of core needle biopsy (CNB) in the breast tumor after two cycles of neoadjuvant chemotherapy were also collected. Kaplan-Meier curve was used to estimate the event-free survival (EFS).ResultsOf 758 eligible patients, 303 were included and analyzed in the four-cycle group and 455 in the six-cycle group. There was no significant difference between the two groups in terms of the pCR rate (46.5% [95% CI 40.9% - 52.2%] in the four-cycle group and 49.9% [95% CI 45.3% - 54.5%] in the six-cycle group, p = 0.365) or the four-year EFS (90.8% in four-cycle group and 93.8% in six-cycle group; p = 0.264). Multivariable analysis indicated that a negative hormone receptor status and the weekly paclitaxel were independent factors for predicting pCR. After adjusting for factors in the multivariable analysis, there was still no significant difference between four and six cycles of neoadjuvant TCH (OR = 1.252, 95% CI 0.904 - 1.733, p = 0.176). Furthermore, 17.9% patients with invasive carcinoma on CNB after two cycles of TCH ultimately achieved pCR in the breast after the completion of neoadjuvant treatment.ConclusionFour cycles of taxane/carboplatin-based neoadjuvant anti-HER2 therapy may be applied as an optimal treatment duration for screening high-risk HER2-positive breast cancer patients for escalation treatment. Further prospective study is warranted.
High Prevalence of Multimorbidity and Polypharmacy in Elderly Patients With Chronic Pain Receiving Home Care are Associated With Multiple Medication-Related Problems
Authors: Schneider Juliana , Algharably Engi Abd Elhady , Budnick Andrea , Wenzel Arlett , Dräger Dagmar , Kreutz Reinhold 
Published: June 2021

Aim: To measure the extent of polypharmacy, multimorbidity and potential medication-related problems in elderly patients with chronic pain receiving home care.Methods: Data of 355 patients aged ≥65 years affected by chronic pain in home care who were enrolled in the ACHE study in Berlin, Germany, were analyzed. History of chronic diseases, diagnoses, medications including self-medication were collected for all patients. Multimorbidity was defined as the presence of ≥2 chronic conditions and levels were classified by the Charlson-Comorbidity-Index. Polypharmacy was defined as the concomitant intake of ≥5 medications. Potentially clinically relevant drug interactions were identified and evaluated; underuse of potentially useful medications as well as overprescription were also assessed.Results: More than half of the patients (55.4%) had moderate to severe comorbidity levels. The median number of prescribed drugs was 9 (range 0–25) and polypharmacy was detected in 89.5% of the patients. Almost half of them (49.3%) were affected by excessive polypharmacy (≥10 prescribed drugs). Polypharmacy and excessive polypharmacy occurred at all levels of comorbidity. We detected 184 potentially relevant drug interactions in 120/353 (34.0%) patients and rated 57 (31.0%) of them as severe. Underprescription of oral anticoagulants was detected in 32.3% of patients with atrial fibrillation whereas potential overprescription of loop diuretics was observed in 15.5% of patients.Conclusion: Multimorbidity and polypharmacy are highly prevalent in elderly outpatients with chronic pain receiving home care. Medication-related problems that could impair safety of drug treatment in this population are resulting from potentially relevant drug interactions, overprescribing as well as underuse.
COVID-19 Lockdown: Key Factors in Citizens’ Stress
Authors: Rodríguez Susana , Valle Antonio , Piñeiro Isabel , González-Suárez Rocío , Díaz Fátima M. , Vieites Tania 
Published: June 2021

Background: Confinement due to COVID-19 can have a short‐ and long-term impact on mental health (increased levels of stress and anxiety and emotional upheaval) and on people’s quality of life. Knowing what factors are behind the stress can benefit the development of strategies and resources for future situations of a similar nature. The purpose of this study is to examine the incidence of a series of sociodemographic factors, confinement conditions, and work situation on the stress reported by confined citizens.Method: The sample is made up of 2008 citizens (19.9% men), the Perceived Stress Scale of 14 items (PSS-14) was used to assess the stress level of the population, as well as a sociodemographic questionnaire and different questions aimed at obtain information about the characteristics of the confinement and the employment situation. Data were collected using exponential snowball-type non-probability sampling.Results: The results suggest that sociodemographic factors such as age, gender, and income level could be good predictors of confinement stress. Post-confinement work expectancy along with pre-confinement working conditions can be key to protecting the well-being of confined populations.Limitations: This is a transversal study that forces us to be cautious with causal interpretations. The questionnaire was administered online, which means it excluded a good proportion of the population.Conclusion: The perception of stress being higher in women than men, with the lowest stress in older people and those with higher reported incomes. Stress levels increase as populations spend more weeks in confinement and the pre-confinement work situation seems key to protecting the well-being of the population. A lower stress is observed among stable couples without children confined in residential or suburban areas. Low income or economic instability is associated with a higher rate of stress and anxiety. The results can contribute to prioritizing actions and aid by contributing to the formation of teams and the design of tools for work in the current pandemic situation.
Prevalence of Major Depressive Disorder Among Adults in China: A Systematic Review and Meta-Analysis
Authors: Zhao Yan-Jie , Jin Yu , Rao Wen-Wang , Zhang Qing-E , Zhang Ling , Jackson Todd , Su Zhao-Hui , Xiang Mi , Yuan Zhen , Xiang Yu-Tao 
Published: June 2021

Background: Prevalence estimates of major depressive disorder (MDD) among adults in China have varied widely between studies. In this systematic review and meta-analysis, the overall prevalence of MDD in the Chinese population was estimated from published epidemiological studies and potential moderators that account for variability in estimates were assessed.Methods: A systematic literature search was conducted in PubMed, EMBASE, Web of Science, PsycINFO, China National Knowledge Internet (CNKI), and WanFang databases to identify relevant studies. Data analyses were conducted using the Comprehensive Meta-Analysis Version 2.0.Results: Forty studies comprising 1,024,087 subjects were included. The pooled point, 12-month, and lifetime prevalence rates of MDD in China were 1.1% (95% CI: 0.9–1.4%), 1.6% (95% CI: 1.0–2.5%), and 1.8% (95% CI: 1.5–2.2%), respectively. Subgroup and meta-regression analyses revealed gender, marital status, survey year, being published in English language, use of the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic systems and age as significant moderators of MDD prevalence.Conclusion: The overall prevalence of MDD in the Chinese population appears to be lower than that of most countries, but the rates have been increasing over time and are elevated in particular demographic subgroups. Due to the negative consequences of MDD, effective preventive measures, early identification, and timely treatments are still important and should be offered to those in need.
Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive–Compulsive Disorder
Authors: Batistuzzo Marcelo C. , Sottili Bruna A. , Shavitt Roseli G. , Lopes Antonio C. , Cappi Carolina , de Mathis Maria Alice , Pastorello Bruno , Diniz Juliana B. , Silva Renata M. F. , Miguel Euripedes C. , Hoexter Marcelo Q. , Otaduy Maria C. 
Published: June 2021

Background: Recent studies using magnetic resonance spectroscopy (1H-MRS) indicate that patients with obsessive–compulsive disorder (OCD) present abnormal levels of glutamate (Glu) and gamma aminobutyric acid (GABA) in the frontal and striatal regions of the brain. These abnormalities could be related to the hyperactivation observed in cortico-striatal circuits of patients with OCD. However, most of the previous 1H-MRS studies were not capable of differentiating the signal from metabolites that overlap in the spectrum, such as Glu and glutamine (Gln), and referred to the detected signal as the composite measure—Glx (sum of Glu and Gln). In this study, we used a two-dimensional JPRESS 1H-MRS sequence that allows the discrimination of overlapping metabolites by observing the differences in J-coupling, leading to higher accuracy in the quantification of all metabolites. Our objective was to identify possible alterations in the neurometabolism of OCD, focusing on Glu and GABA, which are key neurotransmitters in the brain that could provide insights into the underlying neurochemistry of a putative excitatory/inhibitory imbalance. Secondary analysis was performed including metabolites such as Gln, creatine (Cr), N-acetylaspartate, glutathione, choline, lactate, and myo-inositol.Methods: Fifty-nine patients with OCD and 42 healthy controls (HCs) underwent 3T 1H-MRS in the ventromedial prefrontal cortex (vmPFC, 30 × 25 × 25 mm3). Metabolites were quantified using ProFit (version 2.0) and Cr as a reference. Furthermore, Glu/GABA and Glu/Gln ratios were calculated. Generalized linear models (GLMs) were conducted using each metabolite as a dependent variable and age, sex, and gray matter fraction (fGM) as confounding factors. GLM analysis was also used to test for associations between clinical symptoms and neurometabolites.Results: The GLM analysis indicated lower levels of Glu/Cr in patients with OCD (z = 2.540; p = 0.011). No other comparisons reached significant differences between groups for all the metabolites studied. No associations between metabolites and clinical symptoms were detected.Conclusions: The decreased Glu/Cr concentrations in the vmPFC of patients with OCD indicate a neurochemical imbalance in the excitatory neurotransmission that could be associated with the neurobiology of the disease and may be relevant for the pathophysiology of OCD.
Factors Influencing Development and Implementation of Patients' Access to Electronic Health Records—A Comparative Study of Sweden and the Netherlands
Authors: Cijvat Charlotte D. , Cornet Ronald , Hägglund Maria 
Published: June 2021

Background: Patient-accessible electronic health records (PAEHRs) and associated national policies have increasingly been set up over the past two decades. Still little is known about the most effective strategy for developing and implementing PAEHRs. There are many stakeholders to take into account, and previous research focuses on the viewpoints of patients and healthcare professionals. Many known barriers and challenges could be solved by involving end-users in the development and implementation process. This study therefore compares barriers and facilitators for PAEHR development and implementation, both general and specific for patient involvement, that were present in Sweden and the Netherlands.Methods: There were a total of 14 semi-structured interviews with 16 key informants from both countries, on which content analysis was performed. The Consolidated Framework for Implementation Research was used to guide both the construction of the interview guides and the content analysis.Outcomes: The main barriers present in both countries are resistance from healthcare professionals and technical barriers regarding electronic health record systems and vendors. Facilitators varied across the two contexts, where the national infrastructure and program management were highlighted as facilitators in Sweden and stakeholder engagement (including patients and healthcare professionals) was described as a facilitator in both contexts. Strong leadership was also described as a critical success factor, especially when faced with healthcare professional resistance.Conclusion: Most of the major barriers and facilitators from both countries are covered in existing literature. This study, however, identified factors that can be seen as more practical and that would not have arisen from interviews with patients or physicians. Recommendations for policymakers include keeping the mentioned barriers in mind from the start of development and paving the way for facilitators, mainly strict policies, learning from peer implementers, and patient involvement, when possible. Implementers should focus on strong decision-making and project management and on preparing the healthcare organization for the PAEHR.
Cross-Sectoral Zoonotic Disease Surveillance in Western Kenya: Identifying Drivers and Barriers Within a Resource Constrained Setting
Authors: Thomas Lian Francesca , Rushton Jonathan , Bukachi Salome A. , Falzon Laura C. , Howland Olivia , Fèvre Eric M. 
Published: June 2021

Background: Collaboration between the human and animal health sectors, including the sharing of disease surveillance data, has the potential to improve public health outcomes through the rapid detection of zoonotic disease events prior to widespread transmission in humans. Kenya has been at the forefront of embracing a collaborative approach in Africa with the inception of the Zoonotic Disease Unit in 2011. Joint outbreak responses have been coordinated at the national level, yet little is currently documented on cross-sectoral collaboration at the sub-national level.Methods: Key informant interviews were conducted with 28 disease surveillance officers from the human and animal health sectors in three counties in western Kenya. An inductive process of thematic analysis was used to identify themes relating to barriers and drivers for cross-sectoral collaboration.Results: The study identified four interlinking themes related to drivers and barriers for cross-sectoral collaboration. To drive collaboration at the sub-national level there needs to be a clear identification of “common objectives,” as currently exemplified by the response to suspected rabies and anthrax cases and routine meat hygiene activities. The action of collaboration, be it integrated responses to outbreaks or communication and data sharing, require “operational structures” to facilitate them, including the formalisation of reporting lines, supporting legislation and the physical infrastructure, from lab equipment to mobile phones, to facilitate the activities. These structures in turn require “appropriate resources” to support them, which will be allocated based on the “political will” of those who control the resources.Conclusions: Ongoing collaborations between human and animal disease surveillance officers at the sub-national level were identified, driven by common objectives such as routine meat hygiene and response to suspected rabies and anthrax cases. In these areas a suitable operational structure is present, including a supportive legislative framework and clearly designated roles for officers within both sectors. There was support from disease surveillance officers to increase their collaboration, communication and data sharing across sectors, yet this is currently hindered by the lack of these formal operational structures and poor allocation of resources to disease surveillance. It was acknowledged that improving this resource allocation will require political will at the sub-national, national and international levels.
Anaerobic Digestion of Food Waste, Brewery Waste, and Agricultural Residues in an Off-Grid Continuous Reactor
Authors: Miller Kimberley E. , Herman Tess , Philipinanto Dimas A. , Davis Sarah C. 
Published: June 2021

Small-scale anaerobic digestion (AD) can be an effective organic waste management system that also provides energy for small businesses and rural communities. This study measured fuel production from digestions of single and mixed feedstocks using an unheated, 2 m3 digester operated continuously in a temperate climate for over three years. Using local food waste, brewery waste, grease waste, and agricultural residues, this study determined that small-scale AD co-digestions were almost always higher yielding than single feedstocks during psychrophilic operation and seasonal temperature transitions. Agricultural residues from Miscanthus x giganteus had the greatest impact on biomethane production during co-digestion (4.7-fold greater average biogas %CH4), while mesophilic digestion of brewery waste alone produced the most biogas (0.76 gCH4 gVS−1 d−1). Biogas production during the transition from mesophilic to psychrophilic was temporarily maintained at levels similar to mesophilic digestions, particularly during co-digestions, but biogas quality declined during these temperature shifts. Full-time operation of small-scale, unheated AD systems could be feasible in temperate climates if feedstock is intentionally amended to stabilize carbon content.
Penerapan Teknologi Tepat Guna Mesin Pengepres Sampah Plastik Sebagai Bahan Baku Daur Ulang
Authors: Muharsono  , Sri Sutrismi  , Desi Rahmawati  , Marlena  
Published: June 2021

Abstract
The people of Sobontoro in district Boyolangu and Blumbang in district Campurdarat have a very good concern to manage the plastic waste. Their activities aim to help government create the healthy environment. They plan to build the community which is free from the adverse and dangerous effects of plastic waste. The community has formed a Bank of plastic waste to collect plastic waste for many years. What they have done brought a positive thing. The plastic waste which was initially scattered around their house complex collected and pressed to reduce the volume of waste. The well packed and pressed plastic waste can be more valuable and useful as raw material for recycling plastic products with the help of appropriate technology to be implemented in the community. The problems faced by the Bank of plastic waste relating with the insufficient knowledge about the harmful impact of plastic waste on the environment. The next issue deals with the absence of the appropriate technology to press the plastic waste for the sake of the efficiency in the case of the storage of plastic waste and in the distributing the plastic waste to the factory where the waste will be recycled. The method of carrying out the PPTTG activity involves stakeholders, the public and students. The outputs produced are products (the pressing machines of plastic waste), articles published in national journals, the videos, publications in electronic media and intellectual property right (industrial design and copyright).
Abstrak
Masyarakat Desa Sobontoro Kecamatan Boyolangu dan Desa Campurdarat Kecamatan Campurdarat memiliki kepedulian terhadap pengelolaan sampah plastik dalam mewujudkan lingkungan yang sehat, bebas dari dampak buruk sampah plastik. Masyarakat membentuk kelompok Bank Sampah untuk mengepul limbah plastik sehingga plastik yang awalnya berserakan, dikumpulkan dan dipress untuk mengurangi volume sampah kemudian dimanfaatkan sebagai bahan baku daur ulang produk yang terbuat dari plastik dengan bantuan Teknologi Tepat Guna untuk diimplementasikan pada masyarakat. Permasalahannya, pengetahuan tentang dampak limbah plastik terhadap lingkungan masih terbatas dan belum memiliki teknologi tepat guna mesin pengepress sampah plastic agar efisiensi tempat dan menambah volume pengepulan sampah plastik sehingga dapat menambah pendapatan serta menyediakan lapangan kerja. Metode pelaksanan kegiatan melibatkan pemangku kepentingan, masyarakat dan mahasiswa. Luaran yang dihasilkan adalah produk (mesin pengepres sampah), artikel yang di muat di jurnal nasional, video kegiatan, publikasi di media elektronik dan kekayaan intelektual (desain industri dan hak cipta).