bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBERDAYAAN KELOMPOK NELAYAN DALAM PEMBUATAN IKAN ASAP DAN PEMANFAATAN LIMBAH PERIKANAN MENJADI PAKAN PUYUH DI DESA KUALA TAMBANGAN KABUPATEN TANAH LAUT
Authors: Kuswoyo Anton , Zein Mufrida , Syahyuniar Rusuminto 
Published: March 2021

Kelompok nelayan “Mandiri Putra” Desa Kuala Tambangan Kecamatan Takisung Kabupaten Tanah Laut, merupakan sekumpulan nelayan yang setiap hari bekerja mencari ikan di laut. Terdiri dari 10 anggota. Mereka menangkap ikan menggunakan pukat, jaring, jala, dan pancing. Biasanya dalam satu perahu memuat 2-3 pekerja (awak perahu) yang membantu menangkap ikan. Para nelayan menghadapi tiga permasalahan yaitu: harga ikan hasil tangkapan naik turun dan bahkan cenderung murah sehingga penghasilan nelayan pas-pasan; sebagian hasil tangkapan (25%-30%) hanya menjadi limbah yang tidak laku dijual serta belum dimanfaatkan sehingga mengurangi pendapatan nelayan; dan selama ini mitra belum memiliki kemampuan mengolah hasil perikanan, belum memiliki keterampilan pemasaran produk (ikan hasil tangkapan), sehingga masih sangat tergantung pada tengkulak ikan. Maka solusi yang diterapkan pada kelompok nelayan tersebut adalah melatih pembuatan ikan asap dan mengolah limbah perikanan menjadi pakan puyuh sehingga meningkatkan harga jual ikan. Selain itu juga meningkatkan nilai guna limbah perikanan menjadi pakan puyuh. Nelayan juga dilatih memasarkan produk dan manajemen usaha. Hasilnya, nelayan telah mampu membuat ikan asap dan pakan puyuh dari limbah perikanan. Nelayan juga mulai mampu memasarkan produk sehingga menambah penghasilan.
PENGUATAN PERAN POKDARWIS DAN UKM UNTUK PENGEMBANGAN PELAGA AGROTOURISM PARK BERBASIS MASYARAKAT
Authors: Pantiyasa I Wayan , Sutiarso Moh Agus , Suprapto I Nyoman Arto 
Published: March 2021

The goal of community service in the second year (2020) in Pelaga village is to increase the role of tourism aware groups (Pokdarwis) and small business groups (SMEs) for the development of Pelaga Agrotourism Park-based on community. Through mentoring done by the team has been successfully created preferred tour packages and promotional tools online on Youtube, Facebook and Instagram. Agricultural products as supporting tourism produced by SME groups have been successfully improved quality and performance by using the brand Pelaga Agrotourism Park. It is hoped that the use of destination branding will increase the promotion and marketing of agribusiness products and Pelaga village as an agrotourism destination. Keywords: Pelaga Agrotourism Park, village community empowerment.
A comparative investigation of hierarchical clustering techniques and dissimilarity measures applied to the cell formation problem
Authors: Vakharia Asoo J. , Wemmerlöv Urban 
Published: July 2002

AbstractOne methodology for identifying alternative cell designs is the use of clustering algorithms coupled with dissimilarity measure. This paper investigates the performance of seven hierarchical clustering techniques (six previously developed and one developed specifically for cell formation) and eight dissimilarity measures (three well‐known measures and five versions of a recently developed parametric measure) in the context of cell formation. Twenty‐four data sets, at close to 200 partition levels, and ten measures of performance, are used for this purpose. We first identify clustering techniques and dissimilarity measures which should not be used for cell formation when binary data are involved. From the remaining clustering techniques and dissimilarity measures, we then identify clustering technique/dissimilarity measure combinations which are consistently good or poor performers when cell characteristics are observed. High internal cell cohesiveness and low levels of machine duplication are shown to be conflicting goals. Clustering techniques' performance dependency on dissimilarity measures, data sets, stopping rules, and metrics are also clearly illustrated. Another result is that choice of clustering technique is more critical than choice of dissimilarity measure. However, differences among clustering techniques (due to chaining tendencies) can be sharply reduced by restricting the solution space for acceptable cell configurations.
Effects of hypnotics on sleep quality and daytime well-being. Data from a comparative multicentre study in outpatients with insomnia
Authors: Hajak G , Clarenbach P , Fischer W , Haase W , Bandelow B , Adler L , Rüther E 
Published: July 2002

SummaryThe effect of treatment (28 days) with zopiclone, triazolam, flunitrazepam and placebo on sleep quality and daytime well-being was proven in a randomised, double-blind, parallel group, multicentre study in private practice. Results of an exploratory statistic of treatment efficacy in a subgroup of 1,291 patients suffering from insomnia are presented. Patients met the following criteria: insomnia lasting at least four weeks and the presence of at least two of the following: 1) sleep latency ≥ 45 minutes, 2) total sleep time ≤ 6 hours, and 3) nocturnal awakening ≥3 times. Treatment efficacy was assessed according to the following factors: either a shortening of sleep latency by at least 15 minutes, or prolongation of total sleep time by at least 20%, or reduction of the number of nocturnal awakenings to three or less and a refreshed feeling in the morning as well as no impairment in daytime well-being due to tiredness or anxiety. The total response rate was markedly higher with zopiclone (42.3%; p = 0.0003) than with placebo (29.0%). Triazolam (36.6%; p = 0.0905) and flunitrazepam (33.1%; p = 0.3401) were also more effective than the placebo, but they both tended to have a lower response rate than with zopiclone (p = 0.1199 and 0.0151, respectively). Total response was found to be essentially a reflection of the response of the socially important parameter of daytime well-being. These results suggest that zopiclone is more effective in the treatment of insomnia than either triazolam or flunitrazepam. Since the response of daytime well-being to therapy was generally poor, this parameter embodies the next main therapeutic challenge in the treatment of patients with insomnia.
The effect of women's role on health: the paradox
Authors: Kabira W.M. , Gachukia E.W. , Matiangi F.O. 
Published: July 2002

AbstractMost societies in Africa are patriarchal in nature. Traditional Africa has allocated the role of nurturing, and ensuring the health of the family and the community as a whole to women. From the age of six, girls begin to work with their mothers, cleaning, sweeping, nursing and caring for the younger children, the aged and the sick. Therefore, the female child is customarily socialized as the custodian of family health. Because women are traditionally responsible for health in African countries and their status in society is low, the status of the health sector has received less attention than other sectors. The paradox of entrusting the woman with the responsibility of health and at the same time denying her the opportunities to influence policies remains a major obstacle. Factors that influence women's health in Africa most commonly include poverty, poor education and poor nutrition. Access to education for African women is a major problem. The impact of a poorly educated mother is passed on to the daughter. In some parts of Africa, female circumcision contributes to the high school dropout rates. Once the girls are withdrawn from school to participate in the ceremonies, they do not return to school. They are encouraged and socialized towards marriage. Africa has the highest fertility rate, the lowest life expectancy (49 years for males and 52 for females, the highest infant mortality rate (114 deaths per 1000 live births); the highest maternal mortality rate and the highest dependency ratio (47% under 15 years and only 3% over 65). The foregoing factors call for urgent attention to health issues, especially those which affect women who are the traditional health providers. There is an unacceptably high rate of unsafe abortion which accounts for up to 30% of maternal mortality in some African countries, and there is growing concern over teenage pregnancies in some African countries. Nearly two‐thirds of the cases of septic abortions are in the 15–19‐year age group and yet African governments and the legal systems would rather not deal with abortion. The gap between mortality and fertility is widening; it doubled between 1972 and 1994 and is expected to double in 2017. In many African countries, children are the only ‘goods’ that women are expected to produce. Unless this attitude changes, fertility rates will continue to rise as women continue to search for their place in society and justify their place within marriages and relationships through child bearing.
Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells
Authors: Mateu Guylaine , Privat Alain , Thibault Jean , Vignon Jacques 
Published: July 2002

AbstractGlutamate toxicity was compared in substantia nigra (SN)/striatum (STR) and SN/cerebellum (CRB) co‐cultures on both the entire neuronal population (neuron specific enolase (NSE) immunopositive cells) and dopaminergic neurons (tyrosine hydroxylase (TH) immunopositive cells). In SN/CRB co‐cultures NSE‐ and TH‐positive cells were more sensitive to glutamate‐induced toxicity than in SN/STR co‐cultures. Moreover, in SN/STR co‐cultures as compared to SN/CRB and SN cultures, glutamate toxicity was prevented to a larger extent by TCP, a non‐competitive NMDA antagonist. These results suggest that target cells induce a differential expression of the different glutamate receptor subtypes in mesencephalic dopaminergic cells. Alternatively, the presence of target cells may induce the selective development of a subpopulation of dopaminergic neurons expressing predominantly NMDA receptors.
A double-blind comparison of sertraline and clomipramine in outpatients with obsessive-compulsive disorder
Authors: Bisserbe JC , Lane RM , Flament MF ,   France-Belgian OCD Study Group
Published: July 2002

SummaryThe aim of this study was to compare the efficacy, safety, and tolerability of sertraline and clomipramine in the treatment of obsessive-compulsive disorder (OCD). Outpatients with DSM-III-R defined OCD for 1 year or longer and scores of ≥ 20 on the YaleBrown Obsessive Compulsive Scale (Y-BOCS), ≥ 7 on the National Institute of Mental Health Global Obsessive-Compulsive Scale (NIMH-OC), ≥ 4 on the Clinical Global Impression Severity of Illness Scale (CGI-S) and ≤17 on the Hamilton Depression Scale (17 item HAMD) were randomized to sertraline (n= 86) or clomipramine (n= 82) once daily for 16 weeks. Initial daily doses of sertraline and clomipramine were 50 mg. After a minimum of 4 weeks, these doses could be increased by 50 mg increments every 2 weeks to a maximum of 200 mg daily if the response was thought inadequate. Efficacy was assessed at the end of 1, 2, 4, 6, 8, 12 and 16 weeks of therapy using the Y-BOCS, NIMH-OC, CGI-S, CGI Improvement Scale (CGI-I) and Clinical Anxiety Scale (CAS). One hundred sixty-eight patients were randomized and received at least one dose of double-blind medication; 86 received sertraline and 82 clomipramine. Mean final daily doses at final visit were clomipramine 90 mg (efficacy evaluable patients 101 mg, completers 110 mg), and sertraline 129 mg (efficacy evaluable patients 132 mg, completers 136 mg). Mean baseline Y-BOCS, NIMH-OC and CGI-S totals were 27.7, 10.1 and 5.5, respectively, for sertraline and 27.4, 9.9 and 5.5, respectively, for clomipramine. Sertraline demonstrated greater efficacy than clomipramine in the intent-to-treat patient group: mean baseline to final visit changes were 50.8% (Y-BOCS), 41.9% (NIMH-OC) and 37.7% (CGI-S) for sertraline and 42.9% (Y-BOCS), 33.8% (NIMH-OC) and 30.0% (CGI-S) for clomipramine (P< 0.05). The number of patients withdrawing because of adverse events was substantially greater for clomipramine (26%) than sertraline (11%) (P< 0.05). The most frequent adverse events for clomipramine were dry mouth (20%), anxiety (17%), constipation (16%), nausea (15%) and somnolence (11%), and for sertraline, diarrhea (12%) and nausea (12%). In this study, sertraline was more effective than clomipramine in the intent-to-treat analysis. The difference in efficacy between the treatments is almost wholly accounted for by a greater number of clomipramine withdrawals due to the poor patient acceptance of clomipramine. The superior tolerability of sertraline and the lower rate of premature treatment withdrawal relative to clomipramine may offer considerable quality of life and compliance benefits in the long-term management of a chronic disorder such as OCD.
The efficacy of a psychiatric halfway house: a study of hospital recidivism and global outcome measure
Authors: Vaslamatzis G , Katsouyanni K , Markidis M 
Published: July 2002

SummaryThe authors investigated the post-halfway house outcome of a sample of 41 former residents of the halfway house of the Department of Psychiatry, Athens University. Two criteria were used: hospital recidivism and global ratings of outcome (which was assessed on the basis of three parameters: rehospitalization, employment and independent living). Mean duration from the time of departure was 32 months (range: 8–52 months). Within this period good outcome and non-recidivism were related with compliance to pharmacotherapy. Most recidivists also had a shorter stay in the halfway house and cases with successful outcome tended to be evaluated higher on the “Behaviour in Halfway House Scale” at the end of the residency.
Effect of tandospirone on tardive dyskinesia and parkinsonian symptoms
Authors: Yoshida K , Sugita T , Higuchi H , Hishikawa Y 
Published: July 2002

SummaryThe authors examined the effect of tandospirone on tardive dyskinesia (TD) and parkinsonian symptoms in an open study. Tandospirone did not bring about any favourable effect on TD, but it had a good effect on the parkinsonian symptoms.
Interleukin‐36α suppresses growth of non‐small cell lung cancer in vitro by reducing angiogenesis
Authors: Xie Xiaoxiao , Hu Haoyue , He Jun , Liu Yanyang , Guo Fengzhu , Luo Feng , Jiang Ming , Wang Li 
Published: March 2021

Interleukin (IL)‐36α, a newly recognized IL‐1 family member, has been previously reported to play a pivotal role in autoimmunity diseases and acute inflammatory reactions. Recently, several studies have indicated that IL‐36α has potential anticancer effects against certain types of cancer. However, the expression pattern and functional role of IL‐36α in non‐small cell lung cancer (NSCLC) have not been elucidated. Here, we report that the mRNA and protein levels of IL‐36α are significantly reduced in NSCLC tissues. Low levels of intratumoral IL‐36α are correlated with higher tumor status, advanced TNM stage, increased vascular invasion and shorter overall survival (OS). Intratumoral IL‐36α expression is an independent prognostic factor for OS (hazard ratio = 3.081; P = 0.012) in patients with NSCLC. Overexpression of IL‐36α in lung cancer cells did not disturb cell proliferation, apoptosis or cell‐cycle distribution in vitro, but markedly inhibited tumor growth in vivo. Mechanistically, IL‐36α reduced the expression and secretion of vascular endothelial growth factor A through inhibiting hypoxia‐inducible factor 1α expression. Finally, decreased IL‐36α expression was associated with high microvessel density and vascular endothelial growth factor A in patients with NSCLC. Together, our findings suggest that IL‐36α expression is a valuable marker indicating poor prognosis in patients with NSCLC.
The continued influence effect: Examining how age, retraction, and delay impact inferential reasoning
Authors: Miller Alyssa L. , Wissman Kathryn T. , Peterson Daniel J. 
Published: March 2021

SummaryResearch suggests exposure to misinformation continues to impact belief and reasoning, even if that misinformation has been corrected (referred to as the Continued Influence Effect, CIE). The proposed experiment explores two potentially important factors that may impact the effect: (a) learner age and (b) length of delay between retraction and final test. During initial learning, participants (both young and older adults) will read six scenarios in which a critical piece of misinformation is either retracted or not retracted. Following no delay, a short (10 min) delay, or a long (2 days) delay, participants will then answer inferential reasoning questions about the previously‐studied scenarios to evaluate how (if at all) the prior retraction impacts reliance on misinformation. Outcomes will better help us to understand the ways in which misinformation (even following retraction) impacts reasoning, an issue of exceeding importance as the proliferation of fake news shows no signs of slowing.
Actuator fault estimation based on generalized learning observer for quasi‐linear parameter varying systems
Authors: Zetina‐Rios Israel I. , Osorio‐Gordillo Gloria‐L. , Vargas‐Méndez Rodolfo A. , Madrigal‐Espinosa Guadalupe , Astorga‐Zaragoza Carlos‐M. 
Published: March 2021

SummaryThis article presents a generalized learning observer (GLO) design for the simultaneous estimation of states and actuator faults for polytopic quasi‐linear parameter varying systems. The proposed approach is based on the use of a GLO, which generalized the existing results on the proportional‐integral observers. Conditions of existence and stability of the observer are given through the stability analysis in the sense of Lyapunov. Its design is obtained in terms of a set of linear matrix inequalities. The performance of the proposed method is evaluated by simulation in a one‐link‐flexible joint robot system.
Polydiketopyrrolopyrroles Carrying Ethylene Glycol Substituents as Efficient Mixed Ion‐Electron Conductors for Biocompatible Organic Electrochemical Transistors
Authors: Krauss Gert , Meichsner Florian , Hochgesang Adrian , Mohanraj John , Salehi Sahar , Schmode Philip , Thelakkat Mukundan 
Published: March 2021

AbstractA comprehensive investigation of four polydiketopyrrolopyrroles (PDPPs) with increasing ethylene glycol (EG) content and varying nature of comonomer is presented, and guidelines for the design of efficient mixed ion‐electron conductors (MIECs) are deduced. The studies in NaCl electrolyte‐gated organic electrochemical transistors (OECTs) reveal that a high amount of EG on the DPP moiety is essential for MIEC. The PDPP containing 52 wt% EG exhibits a high volumetric capacitance of 338 F cm−3 (at 0.8 V), a high hole mobility in aqueous medium (0.13 cm2 V−1 s−1), and a μC* product of 45 F cm−1 V−1 s−1. OECTs using this polymer retain 97% of the initial drain‐current after 1200 cycles (90 min of continuous operation). In a cell growth medium, the OECT‐performance is fully maintained as in the NaCl electrolyte. In vitro cytotoxicity and cell viability assays reveal the excellent cell compatibility of these novel systems, showing no toxicity after 24 h of culture. Due to the excellent OECT performance with a considerable cycling stability for 1200 cycles and an outstanding cell compatibility, these PDPPs render themselves viable for in vitro and in vivo bioelectronics.
Ductile‐Metal Ag as Buffer Layer for Flexible Self‐Powered Ag2S Photodetectors
Authors: Lei Yan , Gu Longyan , Yang Xiaogang , Lin Yuan , Zheng Zhi 
Published: March 2021

AbstractThe rigid nature of inorganic semiconductors makes them rarely use in flexible devices till now. For the first time, ductile‐metal Ag is used as buffering layer to bond the inorganic semiconductor thin films and polymer substrate forming a sandwich structure, which has outstanding flexible photoelectric character. The ductile thin Ag layer under Ag2S thin film acts as electrode and buffering material between the Ag2S and polyimide (PI) layers. The strong bonding interaction between Ag2S and Ag can reduce the stress force in Ag2S thin films that is generated during bending, which enhances its flexibility. The resulted Ag2S/Ag/PI film shows excellent electrical performance retentivity. After more than 104 cycles bending test, the conductivity of the Ag2S/Ag/PI films has almost not changed. The prepared Au/PEDOT:PSS/Ag2S/Ag/PI photodetectors are stable in air or N2. It can bear a small bending radius as low as 1.5 mm for ≈4000 bending cycles test without drastic performance decay. In addition, the Ag2S/Ag based flexible photodetectors show a wide spectral response from ultraviolet to near infrared.
Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions
Authors: Faarasse Soukaina , El Kazzouli Saïd , Bourzikat Otmane , Bourg Stéphane , Aci‐Sèche Samia , Bonnet Pascal , Suzenet Franck , Guillaumet Gérald 
Published: March 2021

AbstractDirect and site‐selective C5 and C7 palladium‐catalyzed C−H arylations of 4‐azaindazole N‐oxide have been achieved. A bidentate ligand and Pd(OAc)2 catalyst in toluene promoted the activation of C5 position, while a phosphine ligand and PdCl2 catalyst in DMA directed the arylation at C7 position. Using this new method, the synthesis of C5, C7‐diarylated 4‐azaindazole N‐oxides as well as the C3, C5, C7‐triarylated 4‐azaindazoles was achieved towards future medicinal compounds development.magnified image
Practical Stereoselective Synthesis of C3‐Spirooxindole‐ and C2‐Spiropseudoindoxyl‐Pyrrolidines via Organocatalyzed Pictet‐Spengler Reaction/Oxidative Rearrangement Sequence
Authors: Kondo Masaru , Matsuyama Naoki , Aye Tin Z. , Mattan Irshad , Sato Tomoyuki , Makita Yoshinori , Ishibashi Masami , Arai Midori A. , Takizawa Shinobu , Sasai Hiroaki 
Published: March 2021

AbstractA stereoselective synthetic route to chiral C3‐spirooxindole‐ and C2‐spiropseudoindoxyl‐pyrrolidines was accomplished by an enantioselective organocatalyzed Pictet‐Spengler reaction of tryptamines and isotryptamines followed by a diastereoselective oxidative rearrangement using eco‐friendly oxidants (i. e., NaOCl ⋅ 5H2O and Oxone®). This sequential reaction enables rapid access to chiral C3‐spirooxindole‐ and C2‐spiropseudoindoxyl‐pyrrolidines in a one‐pot process. A Wnt signaling inhibitory assay of the prepared enantioenriched spiro compounds demonstrated that they exhibited moderate activities.magnified image
Small Molecule Imaging Agent for Mutant KRAS G12C
Authors: Koch Peter D. , Quintana Jeremy , Ahmed Maaz S. , Kohler Rainer H. , Weissleder Ralph 
Published: March 2021

AbstractMultiple potent covalent inhibitors for mutant KRAS G12C have been described and some are in clinical trials. These small molecule inhibitors potentially allow for companion imaging probe development, thereby expanding the chemical biology toolkit to investigate mutant KRAS biology. Herein, a series of fluorescent companion imaging drugs for KRAS G12C, using two scaffolds, ARS‐1323 and AMG‐510 is synthesized and tested. Four fluorescent derivatives of each by attaching BODIPY dyes are created. It is found that two fluorescent derivatives (BODIPY FL and BODIPY TMR) of ARS‐1323 bind mutant KRAS and can be used for biochemical binding screens. Unfortunately, these drugs cannot be used as direct imaging agents in cells, likely because of nonspecific membrane labeling. To circumvent this challenge, a two step procedure is then used in cancer cells where an ARS‐1323 alkyne is used for target binding followed by fluorescence imaging after in situ click chemistry with picolyl azide Alexa Fluor 647. It is shown that this approach can be used to image mutant KRAS G12C directly in cells. Given the current lack of mutant KRAS G12C specific antibodies, these reagents can be useful for specific fluorescence imaging.