bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of Evapotranspiration and Variations in Different Land-Cover Regions over the Tibetan Plateau during 1961–2014
Authors: Lin Shan , Wang Genxu , Hu Zhaoyong , Huang Kewei , Sun Xiangyang , Sun Juying , Luo Meng , Xiao Xiao 
Published: February 2021

AbstractIn this study, the spatiotemporal changes and driving factors of evapotranspiration (ET) over the Tibetan Plateau (TP) are assessed from 1961 to 2014, based on a revised generalized nonlinear complementary (nonlinear-CR) model. The average annual ET on the TP was 328 mm. The highest ET value (711 mm) was found in the forest region in the southeastern part of the TP, and the lowest value (151 mm) was found in the desert region in the northwestern part of the TP. In terms of the contribution of different subregions to the total amount of ET for the whole plateau, the meadow and steppe regions contributed the most to the total amount of ET of TP, accounting for 30% and 18.5%, respectively. The interannual ET presented a significant increasing trend with a value of 0.26 mm yr−1 from 1961 to 2014, and a significant positive ET trend was found over 35% of the region, mainly in the southeastern part of the plateau. The increasing trend of ET in swamp areas was the largest, while that in the desert areas was the smallest. In terms of the seasonality, the ET over the plateau and different land-cover regions increased the most in summer, followed by spring, while the change in ET in winter was not obvious. The energy factors dominated the long-term change in the annual ET over the plateau. In addition, the available energy is the controlling factor for ET changes in humid areas such as forests and shrublands. Energy and water factors together dominate the ET changes in arid areas.
Anisotropic Statistics of Lagrangian Structure Functions and Helmholtz Decomposition
Authors: Wang Han , Bühler Oliver 
Published: February 2021

AbstractWe present a new method to estimate second-order horizontal velocity structure functions, as well as their Helmholtz decomposition into rotational and divergent components, from sparse data collected along Lagrangian observations. The novelty compared to existing methods is that we allow for anisotropic statistics in the velocity field and also in the collection of the Lagrangian data. Specifically, we assume only stationarity and spatial homogeneity of the data and that the cross covariance between the rotational and divergent flow components is either zero or a function of the separation distance only. No further assumptions are made and the anisotropy of the underlying flow components can be arbitrarily strong. We demonstrate our new method by testing it against synthetic data and applying it to the Lagrangian Submesoscale Experiment (LASER) dataset. We also identify an improved statistical angle-weighting technique that generally increases the accuracy of structure function estimations in the presence of anisotropy.
Delayed Splenic Rupture After a Percutaneous Transsplenic Approach to Treat Portal Vein Occlusion
Authors: Hwang Jung Han , Kim Jeong Ho , Park Suyoung , Lee Ki Hyun 
Published: February 2021

Purpose: To report a case of delayed splenic rupture after percutaneous transsplenic portal vein stent deployment. Case Report: A 72-year-old male patient presented at a medical center with abdominal pain and reduced liver function according to laboratory tests. Due to a history of right hemihepatectomy and left portal vein occlusion, the percutaneous transhepatic approach was considered inappropriate. Instead, percutaneous transsplenic access was selected as a suitable procedure for portal vein catheterization. Eight days following the procedure, the patient developed abdominal pain, and a computed tomography scan showed a small splenic pseudoaneurysm that was underappreciated at the time. Patient suffered acute splenic rupture 32 days post-procedure. Subsequent embolization was performed, achieving complete hemostasis. Conclusion: The transsplenic approach should be considered when the transhepatic or transjugular approach is unfeasible or difficult to implement. A careful plugging of the puncture tract is necessary to prevent or minimize hemorrhage from the splenic access tract. In addition, careful serial follow-up computed tomography should be used to evaluate the splenic puncture tract.
Effect of Pre-Procedure Clopidogrel With Iliac Vein Stenting in Non-Thrombotic Vein Lesions
Authors: Kibrik Pavel , Arustamyan Michael , Alsheekh Ahmad , Ostrozhynskyy Yuriy , Rabinovich Vera , Marks Natalie , Hingorani Anil , Ascher Enrico 
Published: February 2021

Objectives: Iliac vein stenting is a relatively new procedure in the treatment of chronic venous insufficiency. Research has shown that it is a safe and effective form of treatment, however, one of the well-known risks is in-stent thrombosis. We hypothesize that a single 75 mg dose of Clopidogrel the night prior to the procedures along with a 3-month regimen post-op would decrease the 30-day thrombosis rate. Methods: A retrospective study was performed on 3,518 patients from September 2012 to August 2018 who received an iliofemoral stent. Patients were broken down into 2 main groups: those given Clopidogrel post-stent and those given Clopidogrel both pre- and post-stent. In our practice, we prescribe a 3-month course of Clopidogrel after iliac vein stenting. Patients were also checked for any anticoagulant medications pre- and/or post-stent. The 30-day thrombosis rates were recorded for each patient. Results: 1,205 patients received Clopidogrel pre-procedurally and post-procedurally, 1,941 patients received Clopidogrel only post-procedurally. 372 patients were excluded from the study because they were on other anti-coagulant medications. Mean follow-up for this cohort was 17 months. 112 total patients developed some degree of 30 day in-stent thrombosis (3.6%). 74 patients developed a complete thrombosis of the stent and 38 developed a partial (≤60% occlusion) thrombosis. Of the 1,205 patients who were on clopidogrel pre-stenting, 28 had a complete thrombosis and 10 had a partial in-stent thrombosis. Of the 1,941 patients on Clopidogrel only post-stenting, 46 had a complete thrombosis and 28 had a partial in-stent thrombosis. Using the Chi-squared test, there were no statistically significant differences between the group of patients receiving Clopidogrel pre- and post-stent vs. just post-stent with respect to 30-day any degree of thrombosis rates (complete and partial thrombosis) (p = .33). Using the Chi-squared test, there were no statistically significant differences between the group of patients receiving Clopidogrel pre- and post-stent vs. just post-stent with respect to 30-day complete thrombosis rates (p = .93). Conclusions: There appears to be no statistical difference in 30-day thrombosis rates between those receiving Clopidogrel the night prior vs. those who do not receive Clopidogrel the night prior. Therefore, we conclude that it is not necessary to give this single dose the night prior to iliac vein stenting procedures.
Female breast cancer in New South Wales, Australia, by country of birth: implications for health-service delivery
Authors: Roder David , Zhao George W. , Challam Sheetal , Little Alana , Elder Elisabeth , Kostadinovska Gordana , Woodland Lisa , Currow David 
Published: February 2021

Abstract
Background
NSW has a multicultural population with increasing migration from South East Asia, the Western Pacific and Eastern Mediterranean.

Objective
To compare cancer stage, treatment (first 12 months) and survival for 12 country of birth (COB) categories recorded on the population-based NSW Cancer Registry.

Design
Historic cohort study of invasive breast cancers diagnosed in 2003–2016.

Patients
Data for 48,909 women (18+ ages) analysed using linked cancer registry, hospital inpatient and Medicare and pharmaceutical benefits claims data.

Measurement
Comparisons by COB using multivariate logistic regression and proportional hazards regression with follow-up of vital status to April 30th, 2020.

Results
Compared with the Australia-born, women born in China, the Philippines, Vietnam and Lebanon were younger at diagnosis, whereas those from the United Kingdom, Germany, Italy and Greece were older. Women born in China, the Philippines, Vietnam, Greece and Italy lived in less advantaged areas. Adjusted analyses indicated that: (1) stage at diagnosis was less localised for women born in Germany, Greece, Italy and Lebanon; (2) a lower proportion reported comorbidity for those born in China, the Philippines and Vietnam; (3) surgery type varied, with mastectomy more likely for women born in China, the Philippines and Vietnam, and less likely for women born in Italy, Greece and Lebanon; (4) radiotherapy was more likely where breast conserving surgery was more common (Greece, Italy, and Lebanon) and the United Kingdom; and (5) systemic drug therapy was less common for women born in China and Germany. Five-year survival in NSW was high by international standards and increasing. Adjusted analyses indicate that, compared with the Australian born, survival from death from cancer at 5 years from diagnosis was higher for women born in China, the Philippines, Vietnam, Italy, the United Kingdom and Greece.

Conclusions
There is diversity by COB of stage, treatment and survival. Reasons for survival differences may include cultural factors and healthier migrant populations with lower comorbidity, and potentially, less complete death recording in Australia if some women return to their birth countries for treatment and end-of-life care. More research is needed to explore the cultural and clinical factors that health services need to accommodate.
Beyond torture checklists: an exploratory study of the reliability and construct validity of the Torturing Environment Scale (TES)
Authors: Pérez-Sales Pau , González-Rubio Raquel , Mellor-Marsá Blanca , Martínez-Alés Gonzalo 
Published: February 2021

Abstract
Background
Torture methods have traditionally been quantified using checklists. However, checklists fail to capture accurately both the almost infinite range of available methods of torture and the victims’ subjective experience. The Torturing Environment Scale (TES) was designed as a multidimensional alternative that groups torture methods according to the specific human function under attack. This study aims to do an exploratory assessment of the internal consistency reliability and discriminatory validity of the TES as part of a construct validity assessment in a sample of Basque torture survivors.

Methods
We applied the TES to a sample of 201 torture survivors from the Istanbul Protocol Project in the Basque Country Study (IPP-BC) to profile torturing environments in detention. To estimate the internal consistency reliability of the scale, categorical omega values were obtained for each subscale of the TES. To assess its discriminatory validity, the “known groups” method was used comparing mean scorings by gender, state security forces involved in the detention, and decade (the 1980s to the present) when the events took place.

Results
Men reported more physical pain, while women reported more attacks on self-identity and sexual integrity. The TES also showed significant differences as regards the security forces involved in the detention: Civil Guard (a militarised police) used more manipulation of the environment, threats, fear, pain and extreme pain, as compared to national and regional corps. Finally, although patterns of torture remained mostly unchanged across decades, more recent detentions included more emphasis on psychological attacks: context manipulation, humiliation linked to sexual identity, and attacks to meaning and identity. For all subscales of the TES, categorical omega values ranged from 0.44 to 0.72.

Conclusion
The TES may be a useful tool in profiling torturing environments. Its sensitivity to key contextual variables supports the discriminatory validity of the scale. While some of the subscales showed an acceptable degree of internal consistency, others require further analysis to improve reliability. The scale provides unique insights into the profile of contemporary torture. It will allow for future quantitative research on the relationship between different torturing environments and the medical and psychological consequences thereof.
Uric acid‐induced pancreatic β-cell dysfunction
Authors: Ghasemi Asghar 
Published: February 2021

AbstractHyperuricemia is associated with insulin resistance, pancreatic β-cell dysfunction and consequently with development of type 2 diabetes. Although a direct relationship between high levels of uric acid (UA) and the development of diabetes is still a controversial issue, there is some evidence that strongly points to pancreatic β-cells damage as a result of high serum UA levels. Here, the mechanisms underlying UA-induced β-cell damage are discussed. Available literature indicates that UA can decrease glucose-stimulated insulin secretion and cause β-cell death. The mechanisms underlying these effects are UA-induced oxidative stress and inflammation within the β-cells. UA also stimulates inducible nitric oxide (NO) synthase (iNOS) gene expression leading to NO-induced β-cell dysfunction. Thus hyperuricemia may potentially cause β-cell dysfunction, leading to diabetes. It may be hypothesized that in hyperuricemic subjects, UA-lowering drugs may be beneficial in preventing diabetes.
On a class of Hilbert-type inequalities in the whole plane related to exponent function
Authors: You Minghui 
Published: February 2021

AbstractBy introducing a kernel involving an exponent function with multiple parameters, we establish a new Hilbert-type inequality and its equivalent Hardy form. We also prove that the constant factors of the obtained inequalities are the best possible. Furthermore, by introducing the Bernoulli number, Euler number, and the partial fraction expansion of cotangent function and cosecant function, we get some special and interesting cases of the newly obtained inequality.
Structure of β-glucan from Tibetan hull-less barley and its in vitro fermentation by human gut microbiota
Authors: Nie Chenxi , Yan Xin , Xie Xiaoqing , Zhang Ziqi , Zhu Jiang , Wang Yangfan , Wang Xinlei , Xu Nan , Luo Yiwen , Sa Zhen , Li Xinyang , Liu Huicui , Tian Baoming , Ma Qingyu , Zhang Min , Chen Zhifei , Li Juxiu 
Published: February 2021

Abstract
Background
The influence of β-glucan on the human gut microbiota is closely related to the physicochemical structure of β-glucan. We purified a homogeneous water-soluble polysaccharide from Tibetan hull-less barley 25 and studied its structure and the in vitro fermentation profile.

Results
Analysis by gas chromatography (GC), Fourier-transformed infrared (FT-IR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), and atomic force micrograph (AFM) helped determine the hull-less barley polysaccharide to be a β-glucan (molecular weight: 3.45 × 104 Da), which was further characterized as mixed-linkage (1 → 3)(1 → 4)-linked β-d-glucans. SEM images demonstrated an intricate web structure of the hull-less barley polysaccharide, while the AFM images revealed the presence of small spherical particles in its structure. In addition, the microbiota composition of the hull-less barley polysaccharide group was found to be altered, wherein the abundance of Pantoea, Megamonas, Bifidobacterium, and Prevotella-9 were increased. On the other hand, in vitro fermentation revealed that hull-less barley polysaccharide significantly decreased the pH value and increased the production of acetate, propionate, and butyrate.

Conclusions
Hull-less barley polysaccharide is a type of dietary fiber, and its analysis suggested that it may serve as a prebiotic food supplement for the regulation of the gut microbiota.
Genome-Wide Epigenetic Landscape of Lung Adenocarcinoma Links HOXB9 DNA Methylation to Intrinsic EGFR-TKI Resistance and Heterogeneous Responses
Authors: Su Sheng-Fang , Liu Chia-Hsin , Cheng Chiou-Ling , Ho Chao-Chi , Yang Tsung-Ying , Chen Kun-Chieh , Hsu Kuo-Hsuan , Tseng Jeng-Sen , Chen Huei-Wen , Chang Gee-Chen , Yu Sung-Liang , Li Ker-Chau 
Published: February 2021

PURPOSE Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) show efficacy in treating patients with lung adenocarcinoma with EGFR-activating mutations. However, a significant subset of targeted patients fail to respond. Unlike acquired resistance (AR), intrinsic resistance (IR) remains poorly understood. We investigated whether epigenomic factors contribute to patient-to-patient heterogeneity in the EGFR-TKI response and aimed to characterize the IR subpopulation that obtains no benefit from EGFR-TKIs. PATIENTS AND METHODS We conducted genome-wide DNA methylation profiling of 79 tumors sampled from patients with advanced lung adenocarcinoma before they received EGFR-TKI treatment and analyzed the patient responses. Pyrosequencing was performed in a validation cohort of 163 patients with EGFR-activating mutations. RESULTS A DNA methylation landscape of 216 CpG sites with differential methylation was established to elucidate the association of DNA methylation with the characteristics and EGFR-TKI response status of the patients. Functional analysis of 37 transcription-repressive sites identified the enrichment of transcription factors, notably homeobox ( HOX) genes. DNA methylation of HOXB9 (cg13643585) in the enhancer region yielded 88% sensitivity for predicting drug response (odds ratio [OR], 6.64; 95% CI, 1.98 to 25.23; P = .0009). Pyrosequencing validated that HOXB9 gained methylation in patients with a poor EGFR-TKI response (OR, 3.06; 95% CI, 1.13 to 8.19; P = .019). CONCLUSION Our data suggest that homeobox DNA methylation could be a novel tumor cellular state that can aid the precise categorization of tumor heterogeneity in the study of IR to EGFR-TKIs. We identified, for the first time, an epigenomic factor that can potentially complement DNA mutation status in discriminating patients with lung adenocarcinoma who are less likely to benefit from EGFR-TKI treatment, thereby leading to improved patient management in precision medicine.
Prediction of Adult Height by Machine Learning Technique
Authors: Shmoish Michael , German Alina , Devir Nurit , Hecht Anna , Butler Gary , Niklasson Aimon , Albertsson-Wikland Kerstin , Hochberg Ze’ev 
Published: February 2021

Abstract

Context
Prediction of AH is frequently undertaken in the clinical setting. The commonly used methods are based on the assessment of skeletal maturation. Predictive algorithms generated by machine learning, which can already automatically drive cars and recognize spoken language, are the keys to unlocking data that can precisely inform the pediatrician for real-time decision making.

Objective
To use machine learning (ML) to predict adult height (AH) based on growth measurements until age 6 years.

Methods
Growth data from 1596 subjects (798 boys) aged 0-20 years from the longitudinal GrowUp 1974 Gothenburg cohort were utilized to train multiple ML regressors. Of these, 100 were used for model comparison, the rest was used for 5-fold cross-validation. The winning model, random forest (RF), was first validated on 684 additional subjects from the 1974 cohort. It was additionally validated using 1890 subjects from the GrowUp 1990 Gothenburg cohort and 145 subjects from the Edinburgh Longitudinal Growth Study cohort.

Results
RF with 51 regression trees produced the most accurate predictions. The best predicting features were sex and height at age 3.4-6.0 years. Observed and predicted AHs were 173.9 ± 8.9 cm and 173.9 ± 7.7 cm, respectively, with prediction average error of –0.4 ± 4.0 cm. Validation of prediction for 684 GrowUp 1974 children showed prediction accuracy r = 0.87 between predicted and observed AH (R2 = 0.75). When validated on the 1990 Gothenburg and Edinburgh cohorts (completely unseen by the learned RF model), the prediction accuracy was r = 0.88 in both cases (R2 = 0.77). AH in short children was overpredicted and AH in tall children was underpredicted. Prediction absolute error correlated negatively with AH (P &lt; .0001).

Conclusion
We show successful, validated ML of AH using growth measurements before age 6 years. The most important features for prediction were sex, and height at age 3.4-6.0. Prediction errors result in over- or underestimates of AH for short and tall subjects, respectively. Prediction by ML can be generalized to other cohorts.
Dynamic properties of mitochondria during human corticogenesis
Authors: Baum Tierney , Gama Vivian 
Published: February 2021

ABSTRACT
Mitochondria are signaling hubs responsible for the generation of energy through oxidative phosphorylation, the production of key metabolites that serve the bioenergetic and biosynthetic needs of the cell, calcium (Ca2+) buffering and the initiation/execution of apoptosis. The ability of mitochondria to coordinate this myriad of functions is achieved through the exquisite regulation of fundamental dynamic properties, including remodeling of the mitochondrial network via fission and fusion, motility and mitophagy. In this Review, we summarize the current understanding of the mechanisms by which these dynamic properties of the mitochondria support mitochondrial function, review their impact on human cortical development and highlight areas in need of further research.
EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm
Authors: Caprio Cinzia , Lania Gabriella , Bilio Marchesa , Ferrentino Rosa , Chen Li , Baldini Antonio 
Published: February 2021

ABSTRACT
The Ezh2 gene encodes a histone methyltransferase of the polycomb repressive complex 2 that methylates histone H3 lysine 27. In this study, we investigated whether EZH2 has a role in the development of the pharyngeal apparatus and whether it regulates the expression of the Tbx1 gene, which encodes a key transcription factor required in pharyngeal development. To these ends, we performed genetic in vivo experiments with mouse embryos and used mouse embryonic stem cell (ESC)-based protocols to probe endoderm and cardiogenic mesoderm differentiation. Results showed that EZH2 occupies the Tbx1 gene locus in mouse embryos, and that suppression of EZH2 was associated with reduced expression of Tbx1 in differentiated mouse ESCs. Conditional deletion of Ezh2 in the Tbx1 expression domain, which includes the pharyngeal endoderm, did not cause cardiac defects but revealed that the gene has an important role in the morphogenesis of the third pharyngeal pouch (PP). We found that in conditionally deleted embryos the third PP was hypoplastic, had reduced expression of Tbx1, lacked the expression of Gcm2, a gene that marks the parathyroid domain, but expressed FoxN1, a gene marking the thymic domain. Consistently, the parathyroids did not develop, and the thymus was hypoplastic. Thus, Ezh2 is required for parathyroid and thymic development, probably through a function in the pouch endoderm. This discovery also provides a novel interpretational key for the finding of Ezh2 activating mutations in hyperparathyroidism and parathyroid cancer.