bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling Imprecise and Bipolar Algebraic and Topological Relations using Morphological Dilations
Authors: Bloch Isabelle 
Published: April 2021

Abstract
In many domains of information processing, such as knowledge representation, preference modeling, argumentation, multi-criteria decision analysis, spatial reasoning, both vagueness, or imprecision, and bipolarity, encompassing positive and negative parts of information, are core features of the information to be modeled and processed. This led to the development of the concept of bipolar fuzzy sets, and of associated models and tools, such as fusion and aggregation, similarity and distances, mathematical morphology. Here we propose to extend these tools by defining algebraic and topological relations between bipolar fuzzy sets, including intersection, inclusion, adjacency and RCC relations widely used in mereotopology, based on bipolar connectives (in a logical sense) and on mathematical morphology operators. These definitions are shown to have the desired properties and to be consistent with existing definitions on sets and fuzzy sets, while providing an additional bipolar feature. The proposed relations can be used for instance for preference modeling or spatial reasoning. They apply more generally to any type of functions taking values in a poset or a complete lattice, such as L-fuzzy sets.
Unbrauchbar und unverzichtbar? Zur bleibenden Bedeutung des Begriffs „Freikirche“ im deutschsprachigen Raum
Authors: Iff Markus 
Published: April 2021

Zusammenfassung
Der Begriff Freikirche steht für eine erhebliche Bandbreite christlicher Gemeinschafts-, Spiritualitäts- und Sozialformen; in ihm sind religionssoziologische und theologische Aspekte verschränkt. Unter Bezug u. a. auf E. Troeltsch und auf die Leitsätze der Vereinigung Ev. Freikirchen lassen sich theoretische Grundlagen für eine Analyse der freikirchlichen Phänomene gewinnen. Es zeigt sich, dass der Begriff Freikirche für Strukturmerkmale von Kirche steht, die Authentizität, Freiheit und Partizipation ermöglichen.
„Vom Fluss zur Flusslandschaft?“: Eine Ökumenische Vision für das 21. Jahrhundert ausgehend vom Konsultationsbericht „Towards a More Responsive and Inclusive Ecumenical Vision“
Authors: Lamparter Hanne 
Published: April 2021

Zusammenfassung
Wo steht die Ökumene heute und wie kann eine Vision für die Zukunft aussehen? Diesen grundlegenden Fragen widmeten sich Anfang 2020 dreißig erfahrene Ökumeniker*innen bei einem Treffen im libanesischen Antelias. Sie geben Zeugnis von ihren eigenen Lebensvisionen und formulieren zugleich mögliche Wegmarkierungen für künftiges ökumenisches Handeln. Ihr Bericht ist ein Weckruf an die kommende Generation, ökumenische Herausforderungen anzunehmen und die Gegenwart zu gestalten.
The Relationship between Caring for Employees and the Well-being of the Organisation
Authors: Poškienė Eglė , Coudounaris Dafnis N. , Kazlauskaitė Rūta 
Published: April 2021

Abstract
The aim of this paper is to better understand the meaning of caring for employees at the organisational level as well as to disclose its relationship with the well-being of the organisation. It explores literature on caring for employees at the organisational level by integrating two research streams – the relational and morality perspectives. Building on the findings of this literature review, a number of propositions are proposed that associate the well-being of the organisation with many antecedent factors, i.e., strategic caring, perceived organisational support, disinterested organisational support, organisational caring, caring culture, caring climate and caring leadership. This paper contributes to the literature on the well-being of the organisational members at the level of the organisation.
Distinct Functional and Structural Connectivity of the Human Hand-Knob Supported by Intraoperative Findings
Authors: Simone Luciano , Viganò Luca , Fornia Luca , Howells Henrietta , Leonetti Antonella , Puglisi Guglielmo , Bellacicca Andrea , Bello Lorenzo , Cerri Gabriella 
Published: April 2021

Fine motor skills rely on the control of hand muscles exerted by a region of primary motor cortex (M1) that has been extensively investigated in monkeys. Although neuroimaging enables the exploration of this system also in humans, indirect measurements of brain activity prevent causal definitions of hand motor representations, which can be achieved using data obtained during brain mapping in tumor patients. High-frequency direct electrical stimulation delivered at rest (HF-DES-Rest) on the hand-knob region of the precentral gyrus has identified two sectors showing differences in cortical excitability. Using quantitative analysis of motor output elicited with HF DES-Rest, we characterized two sectors based on their excitability, higher in the posterior and lower in the anterior sector. We studied whether the different cortical excitability of these two regions reflected differences in functional connectivity (FC) and structural connectivity (SC). Using healthy adults from the Human Connectome Project (HCP), we computed FC and SC of the anterior and the posterior hand-knob sectors identified within a large cohort of patients. The comparison of FC of the two seeds showed that the anterior hand-knob, relative to the posterior hand-knob, showed stronger functional connections with a bilateral set of parietofrontal areas responsible for integrating perceptual and cognitive hand-related sensorimotor processes necessary for goal-related actions. This was reflected in different patterns of SC between the two sectors. Our results suggest that the human hand-knob is a functionally and structurally heterogeneous region organized along a motor-cognitive gradient.SIGNIFICANCE STATEMENTThe capability to perform complex manipulative tasks is one of the major characteristics of primates and relies on the fine control of hand muscles exerted by a highly specialized region of the precentral gyrus, often termed the “hand-knob” sector. Using intraoperative brain mapping, we identify two hand-knob sectors (posterior and anterior) characterized by differences in cortical excitability. Based on resting-state functional connectivity (FC) and tractography in healthy subjects, we show that posterior and anterior hand-knob sectors differ in their functional connectivity (FC) and structural connectivity (SC) with frontoparietal regions. Thus, anteroposterior differences in cortical excitability are paralleled by differences in FC and SC that likely reflect a motor (posterior) to cognitive (anterior) organization of this cortical region.
Increased Excitatory Synaptic Transmission Associated with Adult Seizure Vulnerability Induced by Early-Life Inflammation in Mice
Authors: Gomez Carlos D. , Acharjee Shaona , Lewis Megan L. , Read Justin , Pittman Quentin J. 
Published: April 2021

Early-life inflammatory stress increases seizure susceptibility later in life. However, possible sex- and age-specific differences and the associated mechanisms are largely unknown. C57BL/6 mice were bred in house, and female and male pups were injected with lipopolysaccharide (LPS; 100 μg/kg, i.p.) or vehicle control (saline solution) at postnatal day 14 (P14). Seizure threshold was assessed in response to pentylenetetrazol (1% solution, i.v.) in adolescence (∼P40) and adulthood (∼P60). We found that adult, but not adolescent, mice treated with LPS displayed ∼34% lower seizure threshold compared with controls. Females and males showed similar increased seizure susceptibility, suggesting that altered brain excitability was age dependent, but not sex dependent. Whole-cell recordings revealed no differences in excitatory synaptic activity onto CA1 pyramidal neurons from control or neonatally inflamed adolescent mice of either sex. However, adult mice of both sexes previously exposed to LPS displayed spontaneous EPSC frequency approximately twice that of controls, but amplitude was unchanged. Although these changes were not associated with alterations in dendritic spines or in the NMDA/AMPA receptor ratio, they were linked to an increased glutamate release probability from Schaffer collateral, but not temporoammonic pathway. This glutamate increase was associated with reduced activity of presynaptic GABABreceptors and was independent of the endocannabinoid-mediated suppression of excitation. Our new findings demonstrate that early-life inflammation leads to long-term increased hippocampal excitability in adult female and male mice associated with changes in glutamatergic synaptic transmission. These alterations may contribute to enhanced vulnerability of the brain to subsequent pathologic challenges such as epileptic seizures.SIGNIFICANCE STATEMENTAdult physiology has been shown to be affected by early-life inflammation. Our data reveal that early-life inflammation increases excitatory synaptic transmission onto hippocampal CA1 pyramidal neurons in an age-dependent manner through disrupted presynaptic GABABreceptor activity on Schaffer collaterals. This hyperexcitability was seen only in adult, and not in adolescent, animals of either sex. The data suggest a maturation process, independent of sex, in the priming action of early-life inflammation and highlight the importance of studying mature brains to reveal cellular changes associated with early-life interventions.
Analysis of the target group of lactose-free functional foods for product development
Authors: Szabó E. , Szakos D. , Kasza Gy. , Ózsvári L. 
Published: April 2021

Abstract
The aim of this research was to assess the consumer habits of lactose sensitive persons in case of lactose-free products and their other shopping aspects for development of new, dairy-based lactose-free products. The research was based on face-to-face questionnaire survey, and those who declared to be lactose sensitive were analysed. Among them, only half of the women (49.3%) and one third of the men (34.6%) were medically proven lactose sensitive, so more than half of the respondents declared themselves affected on the basis of self-diagnosis. Our results show that reliably regular customers of lactose-free products are women and persons with medical diagnosis, high educational degree, and under the age of 30. The lactose-free consumer group prefers the following product features: lactose-free label; rich in calcium, vitamins, and fibre, and free of carbohydrate, sugar, and gluten. Only two-thirds of lactose sensitive customers (66.7%) consume lactose-free products regularly, so it can be assumed that the level of knowledge of this disease, its treatment, and the importance of lactose-free dairy products among these persons is insufficient. This could be solved with education, advertisement, and other information opportunities.
Identification of ovine-associated staphylococci by MALDI-TOF mass spectrometry
Authors: Tonamo A. , Komlósi I. , Varga L. , Kačániová M. , Peles F. 
Published: April 2021

AbstractThe objective of this study was to use matrix-assisted laser desorption ionisation–time of flight mass spectrometry (MALDI-TOF MS) for the identification of ovine-associated staphylococci. Presumptive Staphylococcus isolates were recovered from ovine udder surface (US), individual raw milk, bulk tank milk, and cheese samples and were characterised by conventional phenotypic methods. A total of 69 bacterial isolates were further confirmed by MALDI-TOF MS. Forty-two (60.9%) of 69 isolates were successfully identified on genus and species level. Two thirds (n = 28) of the 42 identified isolates were shown to be Staphylococcus spp. These 28 staphylococcal isolates formed two clusters, one consisting of 22 Staphylococcus aureus strains and the other composed of 6 non-aureus staphylococci, including S. simulans (n = 3), S. auricularis, S. equorum, and S. haemolyticus. MALDI-TOF MS has proven to be a reliable tool for the identification of staphylococci from raw sheep's milk, especially bulk tank milk; however, currently it appears to be less useful for the identification of bacterial isolates originating from ovine US samples. This is the first study to evaluate the applicability of MALDI-TOF MS for identification of Staphylococcus spp. in ovine raw milk, cheese, and US samples in Hungary.
Substitution of potassium sorbate preservative by fermented wheat flour in the production of biscuits. Safety, nutritional and sensory characteristic potentials
Authors: Fink R. , Filip S. 
Published: April 2021

AbstractIn this study, the potential of the substitution of the conventional preservative potassium sorbate by fermented wheat flour as an alternative was analysed. The organic acid content and antibacterial activity of preservatives and the macronutrient characterisation were tested, as was the sensory evaluation of biscuits with added conventional and alternative preservatives. The results show that the fermented wheat flour contains secondary fermentation metabolites (e.g. acetic, lactic and pyruvic acids). Both fermented wheat flour and potassium sorbate have antibacterial effects against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis. The sensory evaluation demonstrated that fermented wheat flour in the recommended concentration range had no impact on sensory quality. Therefore, fermented wheat flour represents a potential substitution for conventional potassium in bakery products.
Antibacterial efficacy of ethyl pyruvate treatment against Escherichia coli O157:H7 and Salmonella Typhimurium on cherry tomatoes
Authors: Ucak Ozkaya G. , Besir A. , Metin E. , Durak M.Z. 
Published: April 2021

ABSTRACTCherry tomatoes inoculated with Escherichia coli O157:H7 and Salmonella Typhimurium were treated with vaporised ethyl pyruvate (EP). The changes of microbial and organoleptic properties of the samples during storage were investigated at two temperatures (4 and 10 °C) and four EP concentrations (0, 42, 105, and 420 ppm) for 7 days at 4 °C and for 5 days 10 °C. After 3 days, 4.3 log and 3.6 log reductions in E. coli O157:H7 numbers were detected in cherry tomatoes treated with 42 ppm EP at 4 °C and at 10 °C, respectively. The highest EP treatment (420 ppm) led to 5.7 log CFU g−1 E. coli O157:H7 reduction after 1 day at 4 and 10 °C. The reduction of Salmonella Typhimurium on samples treated with 420 ppm EP was 7.7 log CFU g–1 after 1 day at 4 °C, and 6.9 log after 1 day at 10 °C. The treatment of EP can be effective at decreasing pathogen populations and can protect the organoleptic and colour properties of fresh produce.
A potential role for psilocybin in the treatment of obsessive-compulsive disorder
Authors: Jacobs Edward 
Published: April 2021

AbstractThe recent revivification of interest in the therapeutic use of psychedelics has had a particular focus on mood disorders and addiction, although there is reason to think these drugs may be effective more widely. After outlining pertinent aspects of psilocybin and obsessive-compulsive disorder (OCD), the current review summarizes the evidence indicating that there may be a role for psilocybin in the treatment of OCD, as well as highlighting a range of potential therapeutic mechanisms that reflect the action of psilocybin on brain function. Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.
Psychedelic-assisted psychotherapy for depression: How dire is the need? How could we do it?
Authors: Earleywine Mitch , De Leo Joseph 
Published: April 2021

AbstractDespite the popular support for psychedelics as aids for depression, academics and the public frequently overestimate the efficacy of available medications and psychotherapies. Metaanalyses reveal that antidepressant medications alone help only one in four patients and rarely surpass credible placebos. Their effects, though statistically significant, might not impress depressed patients themselves. Psychotherapies create better outcomes than antidepressant drugs alone; combining the two provides measurable advantages. Nevertheless, the best combinations help only 65% of the clients who complete treatment. The drugs create side-effects and withdrawal surprisingly more severe than professional guidelines imply, too. Psychedelics appear to improve depression through some of the same mechanisms as psychotherapy, as well as some novel ones, suggesting that the combination could work very well. In addition, subjective experiences during the psychedelic sessions covary with improvement. Guiding clients to focus on these targeted thoughts and feelings could improve outcome. These data underscore the serious need for clinical trials of psychedelic-assisted, empirically supported treatment for depression with guided experiences during the psychedelic session. These trials would require important components to maximize their impact, including meaningful preparatory sessions designed to enhance motivation and explain empirically supported approaches, guided administration sessions that focus on oceanic boundlessness, integration sessions that support progress, and follow-up sessions consistent with established research. This combination involves markedly more than a simple pairing of medication and talk therapy, but proper application could have an unparalleled impact on public health.
Passive system optimization in office buildings using a reference testbed building
Authors: Bonjar Mohammad Reza Ganjali , Horváth Kristóf Roland , Baranyai Bálint , Kistelegdi István 
Published: April 2021

AbstractThe purpose of this research is the application of a passive design strategy for office buildings, the wall-window-ratio optimization under moderate climate. A simplified thermal and lighting simulation model of an office research building served as reference testbed for thermal comfort, daylight factor and illuminance as well as heating, cooling and lighting energy demand assessment. These six performance types of similarly oriented room groups are evaluated via a self-developed weighting process to determine the orientation dependent optimal wall-window-ratio of all room groups. This multi objective optimization applies in a broad range of office buildings under moderate climate.
Everyday issues in women with bleeding disorders
Authors: Skouw-Rasmussen Naja , Pollard Debra 
Published: April 2021

Abstract
Men and women with bleeding disorders have similar symptoms but their experiences are different. It has been shown that women with a bleeding disorder rate their quality of life on a par with that of men with haemophilia who have HIV. Many factors determine quality of life, ranging from delay in diagnosis, to access to treatment and support from family and friends. Women should ask themselves what is important to them and recognise the barriers that determine whether they can achieve their aims in life. Quality of life instruments do not measure the impact of these disorders in a way that is specific to women. Psychosocial health – i.e. the mental, emotional, social, and spiritual aspects of what it means to be healthy – can have a major impact on quality of life. Women with bleeding disorders face a number of challenges to their psychosocial health. They struggle to be believed, they live with guilt, and they may have to fight for the best care for their children. They face obstacles to building relationships and their experiences can leave them isolated. Perhaps because of this, women with bleeding disorders are strong – but they also need to be encouraged to make time for themselves and look after their mental health.
COVID-19’DA KARDİYOTORASİK RADYOLOJİK GÖRÜNTÜLEME VE YAPAY ZEKANIN ROLÜ
Authors: AYYILDIZ Veysel  Atilla 
Published: April 2021

ÖZET
Covid-19'un görüntülemesiyle ilgili bulgular 2020'nin başlarında yayınlandığından beri çok şey öğrenildi. Görüntüleme çalışmalarını bildirmek için birçok sınıflandırma sistemi, karakteristik görüntüleme bulgularına dayanarak geliştirilmiştir. Görüntülemedeki artmış performans ve RT-PCR (Revers Transkriptaz-Polimeraz Zincir Reaksiyonu) testine erişimin kolaylaşması sonucu görüntüleme yalnızca daha şiddetli hastalığı olan veya solunumu kötüleşen hastalar için endikedir. Enfeksiyon, asemptomatik tablodan şiddetli ve bazen ölümcül hastalığa kadar değişen bir spektrumda ortaya çıkmakla beraber, en sık akut akciğer hasarı görülür. Görüntüleme başlangıçta alternatif olarak BT (Bilgisayarlı Tomografi) ile ortaya çıkıp sonradan muhtemelen RT-PCR'na kıyasla daha üstün bir test olarak, spesifik endikasyonlara dayalı daha sınırlı bir rol almıştır. Salgının başlarında, Covid-19 şüphesi olan hastalar için, RT-PCR testinin kullanılabilirliğinin sınırlı olduğu ve performansının belirsiz olduğu durumlarda triyaj amacıyla göğüs görüntüleme için çeşitli sınıflandırma ve raporlama şemaları geliştirilmiştir. Covid-19'a özgü tipik bulgulara sahip özellikler ve alternatif bir tanıyı öneren özellikler için gözlemciler arası anlaşma, çok sayıda çalışmada yüksektir. Göğüs grafisi (GG) ve BT'deki akciğer tutulumunun derecesini değerlendiren bazı çalışmalar, kritik hastalık ve mekanik ventilasyon ihtiyacı ile korelasyon göstermiştir.
Pulmoner belirtilere ek olarak, tromboembolizm ve miyokardit gibi kardiyovasküler komplikasyonlar, bazen nörolojik ve abdominal belirtilere katkıda bulunan Covid-19'a atfedilmiştir. Son olarak yapay zeka, hem radyografi hem de BT açısından Covid-19 pnömonisinin hem tanı hem de prognozunda umut vadetmektedir.
The skin triggers’ therapy in the rehabilitation treatment of patients with fibromyalgia
Authors: Yusova Zhanna Yu. , Kruglova Larisa S. 
Published: April 2021

Materials and methods. 22 patients with fibromyalgia symptom complex were studied. The treatment proposed by the Protocol therapy skin triggers the back botulinum neurotoxin in very low doses.
The results of the study revealed a pronounced clinical efficacy of Botulinum neurotoxin A on the daily functioning of patients and their psycho-emotional status: normalization of sleep, reduced fatigue, a marked reduction in psychovegetative disorders and the absence of pain manifestations, as well as a decrease in the tendency to edema.
Mineral waters of the Republic of North Ossetia — Alania
Authors: Kasinova Agnessa S. , Potapov Yevgeny G. , Rusak Alexander I. , Gusova Berta A. , Gurieva Nina B. 
Published: April 2021

The research objective is to assess the composition and properties of mineral waters of the Republic of North Ossetia Alania.
Material and methods. In 2019, the Testing Laboratory of Natural Therapeutic Resources of North Caucasian Federal Scientific and Clinical Center of Federal Medical and Biological Agency of Russia and the Department of Exploring of Resort Resources of PSRRS North Caucasian Federal Scientific and Clinical Center of Federal Medical and Biological Agency of Russia in Pyatigorsk carried out studies of the mineral waters of the Republic of North Ossetia Alania.
Results. There have been explored mineral waters of Redant, Mamison, Tibian, Tamis, Korinsky, Carmadon and Zamankul mineral water deposits.
Conclusion. The carried out spa studies showed that in the Republic of North Ossetia Alania there is mineral waters of various physical and chemical composition and mineralization that have high balneotherapeutic activity.