bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON OF THERAPEUTIC EFFECTS OF DIFFERENT METHODS OF ADMINISTRATION OF MEZENCHIMAL STEM CELLS TO MICE WITH PREMATURE OVARIAN INSUFFICIENCY
Authors: Kozub M. I. , Skybina K. P. , Musatova I. B. , Prokopiuk O. V. , Gramatiuk S. M. , Tynynyka L. M. , Kozub M. M. , Taran A. V. , Nikolchenko A. Yu. , Prokopiuk O. S. 
Published: June 2021

Premature ovarian insufficiency (POI) is condition of female hypogonadism. One of the reasons for the development of POI is anticancer chemotherapy. Currently, hormone replacement therapy is considered the most effective method of treatment POI, which, however, had a number of side effects, requires constant administration of pharmaceuticals, did not restore fertility and correct pathological changes in target organs. Therefore, the search for alternative methods of treatment based on the use of stem cells is promising. The aim of work was to compare the therapeutic effects of different methods of administration of mesenchymal stem cells isolated from adipose tissue (AT MSCs) in restoring sexual function, as well as the behavior of mice with chemotherapy-induced premature ovarian failure.
Materials and methods. The investigation was carried out on BALB/c mice with a POI model induced by Cyclophosphamide and Busulfan. A histological examination of preparations of the ovaries and uterus was carried out. We studied the changes in the weight of mice, ovarian function, sexual activity, as well as the behavior of animals in anxiolytic and zoosocial tests after treatment with AT MSCs with intraperitoneal and intraovarian routes of administration.
Results and discussion. It was shown that the effectiveness of the use of AT MSCs depends on the method of their administration at the treatment of POI induced by chemotherapy. More rapid and complete restoration of the morphological structure, sexual function, and behavioral responses were observed in mice with POI treated by intraovarial administration of AT MSCs.
Using Ecological Momentary Assessment to Study the Development of COVID-19 Worries in Sweden: Longitudinal Study
Authors: Schulz Peter Johannes , Andersson Elin M , Bizzotto Nicole , Norberg Margareta 
Published: June 2021

Background
The foray of COVID-19 around the globe has certainly instigated worries in many people, and lockdown measures may well have triggered more specific worries. Sweden, more than other countries, relied on voluntary measures to fight the pandemic. This provides a particularly interesting context to assess people’s reactions to the threat of the pandemic.

Objective
The general aim of this study was to better understand the worried reactions to the virus and the associated lockdown measures. As there have been very few longitudinal studies in this area published to date, development of feelings of worry over time was analyzed over a longer range than in previous research. Affective variables, worry in particular, were included because most of the research in this field has focused on cognitive variables. To employ new methodology, ecological momentary assessment was used for data collection and a multilevel modeling approach was adopted for data analysis.

Methods
Results were based on an unbalanced panel sample of 260 Swedish participants filling in 3226 interview questionnaires by smartphone over a 7-week period in 2020 during the rapid rise of cases in the early phase of the pandemic. Causal factors considered in this study included the perceived severity of an infection, susceptibility of a person to the threat posed by the virus, perceived efficacy of safeguarding measures, and assessment of government action against the spread of COVID-19. The effect of these factors on worries was traced in two analytical steps: the effects at the beginning of the study and the effect on the trend during the study.

Results
The level of general worry related to COVID-19 was modest (mean 6.67, SD 2.54 on an 11-point Likert scale); the increase during the study period was small, but the interindividual variation of both the worry level and its increase over time was large. Findings confirmed that the hypothesized causal factors (severity of infection, susceptibility to the threat of the virus, efficacy of safeguarding, and assessment of government preventive action) did indeed affect the level of worry.

Conclusions
The results confirmed earlier research in a very special case and demonstrated the usefulness of a different study design, which takes a longitudinal perspective, and a new type of data analysis borrowed from multilevel study design.
Blockchain for Increased Trust in Virtual Health Care: Proof-of-Concept Study
Authors: Hasselgren Anton , Hanssen Rensaa Jens-Andreas , Kralevska Katina , Gligoroski Danilo , Faxvaag Arild 
Published: June 2021

Background
Health care systems are currently undergoing a digital transformation that has been primarily triggered by emerging technologies, such as artificial intelligence, the Internet of Things, 5G, blockchain, and the digital representation of patients using (mobile) sensor devices. One of the results of this transformation is the gradual virtualization of care. Irrespective of the care environment, trust between caregivers and patients is essential for achieving favorable health outcomes. Given the many breaches of information security and patient safety, today’s health information system portfolios do not suffice as infrastructure for establishing and maintaining trust in virtual care environments.

Objective
This study aims to establish a theoretical foundation for a complex health care system intervention that aims to exploit a cryptographically secured infrastructure for establishing and maintaining trust in virtualized care environments and, based on this theoretical foundation, present a proof of concept that fulfills the necessary requirements.

Methods
This work applies the following framework for the design and evaluation of complex intervention research within health care: a review of the literature and expert consultation for technology forecasting. A proof of concept was developed by following the principles of design science and requirements engineering.

Results
This study determined and defined the crucial functional and nonfunctional requirements and principles for enhancing trust between caregivers and patients within a virtualized health care environment. The cornerstone of our architecture is an approach that uses blockchain technology. The proposed decentralized system offers an innovative governance structure for a novel trust model. The presented theoretical design principles are supported by a concrete implementation of an Ethereum-based platform called VerifyMed.

Conclusions
A service for enhancing trust in a virtualized health care environment that is built on a public blockchain has a high fit for purpose in Healthcare 4.0.
<b>HEDIONDEZ E REINCIDÊNCIA: UMA ANÁLISE DO REQUISITO OBJETIVO NECESSÁRIO PARA A PROGRESSÃO DE REGIME À LUZ DA POLÍTICA CRIMINAL DO CÁRCERE</b><br/>HEINOUS CRIME AND RECURRENCE: AN ANALYSIS OF THE OBJECTIVE REQUIREMENT NECESSARY FOR THE PROGRESSION OF REGIME IN THE LIGHT OF THE CRIMINAL POLICY OF INCARCERATION
Authors: Aleixo (PUC Minas) Klelia Canabrava , Penido (PUC Minas) Flávia Ávila 
Published: June 2021

O presente artigo visa abordar a divergência quanto ao requisito objetivo necessário à concessão da progressão de regime na hipótese de condenados por crimes hediondos ou equiparados. Tal divergência surge em razão da lei não especificar se a fração de 3/5 (três quintos), mais gravosa, aplica-se a reincidentes em crimes hediondos ou equiparados ou a qualquer reincidente, ainda que o crime anterior não seja dessa natureza. Diante desta cisão, pesquisou-se os fundamentos da alteração legislativa, que culminaram no aumento do requisito objetivo, de forma a buscar uma interpretação condizente com o paradigma do Estado de Direito Democrático. Portanto, trata-se de um artigo construído a partir de pesquisas bibliográficas e que se pautou em uma metodologia analítica crítica. Percebeu-se que, em face da carência de teor significante da norma, se firmou o entendimento jurisprudencial que exige a fração de 3/5 (três quintos) do cumprimento da pena pelo condenado reincidente, ainda que o crime anterior não seja hediondo ou equiparado, como requisito objetivo para a concessão da progressão de regime. A extensão do alcance da lei a reincidentes, cujo crime anterior não seja hediondo ou equiparado, fere o princípio da especialidade. A abertura, dada ao intérprete-juiz por texto de lei carente de significação, permitiu, pois, que sua interpretação fosse feita como mecanismo de implementação de políticas repressivas, encarceradoras, de segregação do indesejável conforme a biopolítica vigente.
Una experiencia virtual de aprendizaje sobre la educación estocástica inicial con estudiantes costarricenses de secundaria
Authors: Fallas-Soto Rodolfo 
Published: June 2021

Este estudio tiene como objetivo desarrollar, por medio de un entorno virtual, un espacio para la construcción de significados que se asocien con los conceptos básicos de estadística, como parte del proyecto de Comunidades de Aprendizaje Matemático de la Universidad de Costa Rica y los cursos libres que imparte. Para ello, desde el enfoque socio-epistemológico, se desarrollan las etapas de la ingeniería didáctica para implementar en un grupo de 30 estudiantes (entre 14 y 15 años) el ciclo de investigación estadística propuesto por (Wild y Pfannkuch, 1999). En los resultados se muestran dos organizaciones de prácticas asociadas al actuar del estudiantado cuando comprenden comportamientos de naturaleza estocástica. Además, esta investigación reporta el papel del cambio en la muestra estadística, para asegurar una representatividad de la población de estudio. Se concluye con algunas características de la práctica de inferencia y su relación con una forma de pensar ante comportamientos no deterministas.
Increased Hemoglobin A1c Time in Range Reduces Adverse Health Outcomes in Older Adults With Diabetes
Authors: Prentice Julia C. , Mohr David C. , Zhang Libin , Li Donglin , Legler Aaron , Nelson Richard E. , Conlin Paul R. 
Published: June 2021

OBJECTIVE
Short- and long-term glycemic variability are risk factors for diabetes complications. However, there are no validated A1C target ranges or measures of A1C stability in older adults. We evaluated the association of a patient-specific A1C variability measure, A1C time in range (A1C TIR), on major adverse outcomes.

RESEARCH DESIGN AND METHODS
We conducted a retrospective observational study using administrative data from the Department of Veterans Affairs and Medicare from 2004 to 2016. Patients were ≥65 years old, had diabetes, and had at least four A1C tests during a 3-year baseline period. A1C TIR was the percentage of days during the baseline in which A1C was in an individualized target range (6.0–7.0% up to 8.0–9.0%) on the basis of clinical characteristics and predicted life expectancy. Increasing A1C TIR was divided into categories of 20% increments and linked to mortality and cardiovascular disease (CVD) (i.e., myocardial infarction, stroke).

RESULTS
The study included 402,043 veterans (mean [SD] age 76.9 [5.7] years, 98.8% male). During an average of 5.5 years of follow-up, A1C TIR had a graded relationship with mortality and CVD. Cox proportional hazards models showed that lower A1C TIR was associated with increased mortality (A1C TIR 0 to &lt;20%: hazard ratio [HR] 1.22 [95% CI 1.20–1.25]) and CVD (A1C TIR 0 to &lt;20%: HR 1.14 [95% CI 1.11–1.19]) compared with A1C TIR 80–100%. Competing risk models and shorter follow-up (e.g., 24 months) showed similar results.

CONCLUSIONS
In older adults with diabetes, maintaining A1C levels within individualized target ranges is associated with lower risk of mortality and CVD.
Mortality rate of birds following intravenous administration of iodinated contrast medium for computed tomography
Authors: McCready Julianne E. , Gardhouse Sara M. , Appleby Ryan , Beaufrère Hugues 
Published: June 2021

Abstract

OBJECTIVE
To identify potential risk factors for death following IV or intraosseous (IO) administration of contrast medium in birds undergoing CT scans.

ANIMALS
120 birds that underwent 134 contrast-enhanced CT scans.

PROCEDURES
Medical records of birds of any species that underwent a CT scan which included administration of nonionic iodinated contrast medium from June 2013 to February 2020 were included. Information on birds and use of contrast medium was extracted from the medical records as well as information on deaths following IV or IO administration of contrast medium.

RESULTS
6 birds died shortly following administration of contrast medium. Necropsies were performed in 3 birds (2 cockatiels and 1 macaw), and all had lesions associated with the respiratory tract. When body weight was used as a binary variable to compare odds of death between small birds (≤ 150 g [0.33 lb]) and large birds (> 150 g), small birds had a 97-fold increased odds (OR, 97.5; 95% CI, 9.8 to 966.0) of dying following contrast medium administration. Following 131 CT scans with contrast medium administration (3 scans were excluded because of perivascular or subcutaneous leakage of contract medium), small birds had a mortality rate of 45.4% (5/11), compared with a mortality rate of 0.8% (1/120) for large (> 150 g) birds. Other variables (ie, sex, age, anesthesia or sedation, sedation protocol, and type of contrast medium) were not significantly associated with death after contrast medium administration.

CONCLUSIONS AND CLINICAL RELEVANCE
Although the administration of contrast medium cannot be conclusively confirmed as the cause of death in these birds, the high mortality rate for small birds coupled with the temporality of the event following contrast medium administration justifies the cautious use of contrast medium in small sick psittacine birds. (J Am Vet Med Assoc 2021;259:77–83)
ПРОБЛЕМАТИКА ЕМОЦІЙНОГО ЗДОРОВ’Я СТУДЕНТІВ У КОНТЕКСТІ ДОСЛІДЖЕННЯ ЕМОЦІЙНОЇ ЗРІЛОСТІ
Authors: Микитюк Оксана , Зачепа Андрій , Кулинич Мирослава , Пасічник Михайло , Берест Ігор 
Published: June 2021

У статті представлені результати теоретико-практичного дослідження проблематики емоційної зрілості як особистісної якості у студентів у контексті дослідження емоційного здоров’я. Автори подають інтерпретацію власних наукових досліджень щодо проблематики емоційної зрілості особистості, зокрема студентів Української академії друкарства в контексті дослідження двох компонентів – когнітивно-емоційного і емпатійно-емоційного.
Наведені результати порівняльного аналізу проведеного дослідження, респондентами якого були студенти 3 курсу факультету менеджменту на медіакомунікацій УАД, які зазнали умовного поділу на дві групи за статевою ознакою ( №1 – група студентів жіночої статі; №2 – група студентів чоловічої статі).
ВНЕСОК ГАЛИЦЬКИХ КОМПОЗИТОРІВ У ЗАСНУВАННЯ 1903 РОКУ ВИЩОГО МУЗИЧНОГО ІНСТИТУТУ У ЛЬВОВІ
Authors: Фрайт Іван , Турянський Петро 
Published: June 2021

У статті виявлено внесок галицьких композиторів у заснування 1903 року Вищого музичного інституту у Львові. Встановлено, що Вищий музичний інститут у Львові став першим українським музичним закладом освіти Західної України, у якому цілеспрямовано проводилася робота з підготовки професійних співаків, педагогів, виконавців на різних музичних інструментах.
В організації цього закладу взяли участь майже усі галицькі композитори. Навколо нього гуртувалася і талановита галицька молодь, кращі представники якої гідно представляли українське музичне мистецтво.
ПСИХОЛОГО-ПЕДАГОГІЧНІ ЗАСАДИ РОБОТИ З ОБДАРОВАНОЮ СТУДЕНТСЬКОЮ МОЛОДДЮ
Authors: Ревть Алла , Гриник Ігор 
Published: June 2021

У статті здійснено комплексний аналіз вітчизняних і зарубіжних напрацювань з питань обдарованості студентської молоді; розкрито змістове наповнення провідних понять проблеми. Висвітлено і систематизовано ознаки, види, функції та узагальнено якості обдарованої особистості. Проаналізовано психолого-педагогічні підходи до роботи з обдарованою молоддю.
Досліджено й визначено зміст, форми та методи роботи з обдарованими студентами у закладах вищої освіти в Україні. Охарактеризовано соціальні умови розв’язання проблем особистісної соціальної самореалізації і професійного самовизначення обдарованих студентів у нових соціально-економічних умовах.
Робота з обдарованими студентами вимагає належної змістової наповненості занять, зорієнтованої на новизну інформації та різноманітні види пошукової аналітичної, розвивальної, творчої діяльності.
Unusual course of the vagus nerve passing anterior to the internal carotid artery during carotid endarterectomy
Authors: Kawahara Ichiro , Shiozaki Eri , Soejima Kosuke , Ogawa Yuka , Morofuji Yoichi , Ono Tomonori , Haraguchi Wataru , Tsutsumi Keisuke 
Published: June 2021

Background:
Carotid endarterectomy (CEA) is a conventional surgical technique to prevent ischemic stroke and the effectiveness for advanced lesions is established in many large studies. The vagus nerve is one of the cranial nerves that we usually encounter during CEA manipulation, which is identified as located posterior to the vessels in a position posterolateral to the carotid artery and posteromedial to the internal jugular vein.

Case Description:
We experienced an extremely rare case of the vagus nerve passing anterior to the internal carotid artery during CEA.

Conclusion:
We should be careful not to accidentally cut off because the variation of the vagus nerve can be mistaken for an ansa cervicalis. A delicate and complete dissection to understand the variation of the vagus nerve is crucial to minimize the risk of cranial nerve injury during CEA.
Anaplastic myxopapillary ependymoma of the sacrum: A case report
Authors: Rahimizadeh Abolfazl , Malekmohammadi Zahed , Habibollahzadeh Parviz , Williamson Walter L. , Rahimizadeh Ava 
Published: June 2021

Background:
Myxopapillary ependymoma (MPE) with anaplastic features is extremely rare. There are very few such case reports in the medical literature.

Case Description:
A 23-year-old female presented with lower back pain, and both urinary and fecal dysfunction. The patient underwent gross total surgical excision of the MR documented expansile intrasacral tumor. The histology was compatible with a MPE containing anaplastic features.

Conclusion:
The medical literature contains a few comparable cases of subcutaneous sacrococcygeal MPE with anaplastic components. Here, however, we have a young female with an anaplastic intrasacral MPE treated with gross total surgical excision.
Use of Saito technique to resect an anterior lumbar spine meningioma: Technical note
Authors: Barrenechea Ignacio J. , Marquez Luis M. , Pastor Marcelo 
Published: June 2021

Background:
Complete (Simpson Grade I: total removal) resections for anterior spinal meningiomas are especially challenging. This is largely attributed to difficulty obtaining a water-tight dural repair where the tumor has infiltrated the dura requiring duroplasty, thus often resulting in just a Simpson Grade II resection (i.e. coagulation of the dural implantation site). Here, we present a 56-year-old female who underwent resection of a ventral lumbar meningioma utilizing the Saito technique, that effectively separated the dura into two layers, removing just the inner layer but leaving the outer layer intact for direct dural repair.

Methods:
A 56-year-old female underwent a L1–L2 laminectomy. The anterior intradural resection of tumor was achieved with the Saito technique; this required cutting circumferentially around the tumor insertion site, and removing only the inner layer.

Results:
Postoperatively, the patient did well without tumor recurrence over 8 years. The postoperative biopsy confirmed a World Health Organization Grade I meningothelial meningioma.

Conclusion:
Saito’s technique proved to be a safe and effective method for achieving gross total resection of an anterior lumbar meningioma.
Avaliação na Perspectiva Acional e integração das atividades de linguagem em língua estrangeira
Authors: Pinheiro Luzia Alessandra , Quevedo-Camargo Gladys 
Published: June 2021

Este artigo aborda a avaliação em língua estrangeira na Perspectiva Acional, que tem como pressuposto unir a aprendizagem da língua ao seu uso social real por meio de tarefas nas quais há integração de habilidades. Tem por base uma pesquisa teórica realizada no âmbito de mestrado e versa sobre um processo avaliativo em língua estrangeira que visa associar as atividades de linguagem para aproximar a língua de seu uso real. O texto aborda aspectos sobre a Perspectiva Acional, os gêneros de textos, a avaliação para a aprendizagem e a integração das atividades de linguagem, particularmente de recepção e produção, na avaliação em sala de aula. Propõe que uma avaliação representativa do uso da língua em situações reais de comunicação recorra a procedimentos que integram as atividades de linguagem, como ocorre no mundo real. Os gêneros de textos orais e escritos configuram-se como insumos para agregar as atividades de linguagem. Vincular a recepção Ã produção de textos significa conferir mais autenticidade ao processo avaliativo na lógica acional. O intuito é proporcionar mais uma possibilidade pedagógica para o agir avaliativo do professor de línguas.
Relações psicotipológicas com base no ponto de vista de multilíngues falantes de português (L1), inglês (L2) e alemão (L3)
Authors: Behling Duarte Aline , Mozzillo Isabella Ferreira , Limberger Bernardo Kolling 
Published: June 2021

O objetivo deste estudo foi identificar a percepção de multilíngues falantes de português (L1), inglês (L2) e alemão (L3) sobre as relações psicotipológicas entre essas línguas. Com base nos trabalhos desenvolvidos por Hall et al. (2009), Lindqvist (2015) e Sánchez e Bardel (2016), um questionário de cunho psicotipológico foi elaborado. A utilização da tarefa considerava relações ortográficas, fônico-fonológicas e gramaticais que se estabelecem entre as línguas. Como hipóteses para o trabalho, considerávamos que os participantes avaliariam o par de línguas inglês-alemão, em termos gerais, como mais semelhante. Em relação aos aspectos ortográficos, presumíamos que o par português-alemão seria entendido como distante. Ainda, acreditávamos que em termos fônico-fonológicas, a combinação inglês-alemão fosse escolhida como mais próxima pelos participantes. No que tange Ã gramática das línguas, o par português-inglês seria compreendido como o mais próximo. Após a coleta e a análise dos dados obtidos, os resultados indicaram que as hipóteses levantadas condiziam com a maior parte das avaliações feitas, sendo a única exceção referente Ã s regras sintáticas das línguas. De acordo com os participantes, a combinação inglês-alemão apresenta maiores semelhanças sintáticas e não o par português-inglês.
A gestão da informação sob a ótica do pensamento complexo: uma reflexão
Authors: Santos Beatriz Rosa Pinheiro dos , Valentim Marta Lígia Pomim , Damian Ieda Pelógia Martins 
Published: June 2021

A sociedade contemporânea imersa em uma quantidade significativa de informação deve integrar os mais variados contextos organizacionais e informacionais, a fim de gerar conhecimento com características inter, multi, pluri e transdisciplinares. Nesse cenário, a informação e o conhecimento produzidos necessitam da intervenção do pensamento complexo para a própria valorização e desenvolvimento eficaz de seus processos. No intuito de contribuir para agregar valor aos processos informacionais, apresenta-se o seguinte problema: é possível agregar valor Ã s práticas tradicionais da gestão da informação, por meio dos princípios do pensamento complexo? Objetiva-se discorrer sobre a gestão da informação em consonância Ã ótica do pensamento complexo. A justificativa para o desenvolvimento de tal pesquisa reside em contribuir para o arcabouço teórico da Ciência da Informação que, por sua vez, estuda a gestão da informação nos mais variados contextos organizacionais. Para tanto, realizou-se uma revisão de literatura, em que foi possível verificar quais aspectos do pensamento complexo podem auxiliar na quebra de paradigmas que habitam as práticas tradicionais oriundas de distintos modelos de gestão da informação.