bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitude and practice on safe disposal of medicines among medical personnel
Authors: Kaur Kamalpreet , Bansal Nagma 
Published: August 2021

Increasing disease incidence and prevalence has led to tremendous increase in the use of medications. The consumers are not able to use all the dispensed medications because of various reasons. The improper disposal of these unused medicines has led to environmental contamination to an alarming extent. The present study aims to assess the knowledge, attitude and practice of medical personnel about disposal of unused medicines.

The study was conducted on post graduate medical students, MBBS and nursing students of a tertiary care hospital of North India. It was cross sectional, descriptive study based on a structured questionnaire to assess the knowledge, attitude and practice about the disposition of left over medications. Descriptive statistical analysis of the results was done.
Stockpiling was reported by 100% of the students. The most common reason for stockpiling was excess purchase of medicines (41%). The most commonly procured medicine was NSAID (55.9%). The most common method of disposal was with household waste (69%). Majority of the respondents answered that take back programmes and government interference is the solution to this problem.
: Majority of the people are having unused medicines at home and most commonly they dispose it by throwing along with rubbish. Lack of knowledge regarding proper disposal is the main reason behind this. Initiatives should be taken to spread awareness regarding proper disposal methods of unused medicines.
Analisis Penilaian Financial Distress Dengan Menggunakan Model Altman Z-Score Dan Model Springate Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Periode Tahun 2015-2019
Authors: Anindyka Febriana , Zulkifli Makhmud 
Published: August 2021

The aim of this research to analyze financial distress of Manufature Company by using Altman Z-Score and Springate Models. Moreover, this research aimed to know aims to determine the similarities and differences in the results of the analysis of financial distress assessment using the Altman Z-Score model and the Springate Model. This research used Descriptive statistics and data analysis methods used in this research were Altman Z-Score and Springate Model. To the finding on the research, it showed that (1) ) After evaluating the Altman Z-Score and Springate models, there are fifty companies that fall into different conditions. (2) The similarities and differences in the results of the Atman Z-Score model and the Springate model are the results of the two models that can be seen from having almost the same variable components and the difference is that the results of the financial distress assessment using the Altman Z-score model and the Springate model show that both These models have different criteria in determining the financial condition of a company.
A THE USE OF PARTIAL LEAST SQUARES MODELING IN FINANCE BUSINESS PARTNERING RESEARCH
Authors: Tohari Amin , Faisol Faisol , Rahmad Aeri 
Published: August 2021

Structural equation modeling (SEM) is a set of statistical techniques that allows testing a model that is built between one or more endogenous variables with one or more exogenous variables, where each endogenous and exogenous variable can be in the form of latent or a construct built from several variables of manifest or indicator. There is Structural Equation Modeling (SEM) based on covariance and variance, known as Partial Least Square (PLS), SEM-PLS is a powerful and flexible analysis method. This research discusses about the application of SEM-PLS in the field of managerial accounting system, namely the application of non-financial performance’s role that delivers the sustainability of the company's financial performance. Based on the results obtained, it can be concluded that partial least squares can be used to model finance business partnering, and it is known that employee performance and internal process performance contribute to achieve the firm’s financial performance.
Hubungan Antara Kohesivitas Keluarga dan Self Esteem pada Remaja
Authors: Rusdiana Fendi Krisna 
Published: August 2021

ABSTRACT This study aims to examine the relationship between family cohesiveness and self-esteem in adolescents. The population in this study were students of a private junior high school in Surabaya. The samples taken were students in two class VII and students in two class VIII totaling 110 students. This research uses correlational quantitative method. Sampling using stratified random sampling technique. The data were collected using a family cohesiveness scale and a self-esteem scale. The data analysis technique used is the product moment correlation. The results of data analysis showed a correlation value (r) of 0.411 and a significance value (p) of 0.002. This suggests that there is a relationship between family cohesiveness and self-esteem in adolescents. ABSTRAKPenelitian ini bertujuan untuk menguji hubungan antara kohesivitas keluarga dengan self-esteem pada remaja. Populasi pada penelitian ini adalah siswa salah satu SMP swasta di Surabaya. Sampel yang diambil adalah siswa di dua kelas VII dan siswa di dua kelas VIII berjumlah 110 siswa. Penelitian ini menggunakan metode kuantitatif korelasional. Pengambilan sampel menggunakan teknik stratified random sampling. Pengumpulan data menggunakan skala kohesivitas keluarga dan skala self-esteem. Teknik analisis data yang digunakan adalah korelasi product moment. Hasil analisis data menunjukkan nilai korelasi (r) sebesar 0,411 dan nilai signifikansi (p) sebesar 0,002. Hal ini menyatakan bahwa terdapat hubungan antara kohesivitas keluarga dengan self-esteem pada remaja.
Pressure Response of a Horizontal Well in Tight Oil Reservoirs with Stimulated Reservoir Volume
Authors: Chen Peng , Hu Changpeng , Zou Pingguo , Lin Lili , Lu Song , Gao Xincheng 
Published: August 2021

Abstract
Stimulated reservoir volume is an effective stimulation measure and creates a complex fracture network, but the description and characterization of fracture network are very difficult. Well test analysis is a common method to describe the fracture network, and it is the key to build a proper interpretation model. However, most published works only consider the shape of the fractured area or the stress sensitivity effect, and few works take both factors into account. In this paper, based on reservoir properties and flow law after a stimulated reservoir volume, an interpretation model is established with an arbitrary shape of the fractured area and stress sensitivity effect of different flow areas. The model is solved to conduct the pressure response using Laplace transform, point source function, and boundary element theory. The influence of fractures’ parameters and stress sensitivity effect is analyzed on the pressure behavior. Results from this study show that the special flow regimes for a horizontal well with a stimulated reservoir volume are (1) bilinear flow dominated by hydraulic fractures, (2) linear flow dominated by formation around the hydraulic fractures, (3) crossflow from a matrix system to the fractured area, and (4) radial flow control by properties of the fractured area. Parameters of hydraulic fractures mainly affect the early stage of pressure behavior. On the contrary, the stress-sensitive effect mainly affects the middle and late stages; the stronger the stress sensitivity effect is, the more obvious the effect is. The findings of this study can help for better understanding of the fracture network in a tight oil reservoir with a stimulated reservoir volume.
Configuración territorial de los actores sociales involucrados en la gestión del fuego en la sierra de Los Tuxtlas (México)
Authors: Neger Christoph 
Published: August 2021

En los últimos años, han cobrado importancia los estudios que resaltan el papel de los diferentes actores sociales que participan en la gestión del fuego. Recientemente, algunos trabajos también han incorporado una visión geográfica, indagando en los aspectos territoriales de la gestión. No obstante, hasta la fecha, existe una carencia de investigaciones de esta índole en las zonas tropicales del mundo. El presente trabajo pretende contribuir a subsanar parcialmente esta laguna de conocimiento, analizando la situación en los últimos años (2016 a 2020) en la sierra de Los Tuxtlas, México, un área con una notable incidencia de incendios forestales. Para ello, se han revisado datos oficiales y se han efectuado entrevistas con representantes de los actores involucrados. El procesamiento de los datos ha incluido el análisis de textos que revela las diversas actividades realizadas por los actores. Para profundizar en la comprensión de la configuración territorial de los actores, se presenta una cartografía de la geografía organizativa y de las redes de cooperación. Se demuestran áreas con una presencia destacada de diferentes actores y una densa red social pero también otras zonas con poca o nula actividad y se discuten las razones de esta configuración.
Environment-Friendly Deoxygenation of Non-Edible Ceiba oil to Liquid Hydrocarbon Biofuel: Process Parameters and Optimization Study
Authors: Abdullah Nur Hafawati Binti , Asikin-Mijan Nurul Asikin , Taufiq-Yap Yun Hin , Ong Hwai Chyuan , Lee Hwei Voon 
Published: August 2021

Abstract
Non-edible Ceiba oil has feasibility as a sustainable biofuel resource in tropical countries that act as alternative to a portion of the fossil fuels used today.Catalytic deoxygenation of the Ceiba oil (high O/C ratio) was conducted to produce hydrocarbon biofuel (high H/C ratio)over NiO-CaO5/SiO2-Al2O3catalyst with aims of high diesel selectivity and catalyst reusability. In the present study, Box-Behnken experimental design was used to evaluate and optimize liquid hydrocarbon yieldby considering following reaction factors: catalyst loading (1-9 wt.%), reaction temperature (300 - 380°C) and reaction time (30 -180 min). It was discovered that the optimum yield for hydrocarbon fractionsn-(C8 – C20) was 77% under deoxygenation condition of 5 wt.% catalyst loading, reaction temperature of 340°C within 105 min. Besides, deoxygenationmodel indicated that interaction effects of catalyst loading-reaction time influence the deoxygenation activity greatly. Based on the product analysis, oxygenated species(e.g. CO2 and CO) were removed mainly via decarboxylation/decarbonylation (deCOx) pathways. The NiO-CaO5/SiO2-Al2O3 catalyst is stable for five consecutive runs with hydrocarbon fractions within range of 66-75% and n-(C15+C17) selectivity of 64-72% as well. The stability profile of NiO-CaO5/SiO2-Al2O3 catalyst indicated that the catalyst able to maintain deoxygenation reactivity throughout five cycles with hydrocarbon yield of 66-75% and n-(C15+C17) selectivity of 64–72 %. However, coke deposition was noticed for the spent catalyst after several times of usage, which due to the high reaction temperature above 300 oC.
On the Sustainability Performance of the European Union’s Economic Recovery Strategy – A Case Study with Lessons for Policymakers
Authors: Zachariadis Theodoros 
Published: August 2021

Abstract
The European Union pursues an economic recovery strategy with explicit environmental considerations but less clear alignment with broader sustainable development objectives. Using as a case study one national Recovery and Resilience Plan of an EU country that was published in May 2021, we perform a rapid but detailed sustainability assessment of its measures. This method is embedded in a broader framework that combines ex-post sustainability assessments of international organisations with ex-ante assessments of multi-year public budget plans. At times when policymakers need immediate advice, this framework helps identify weaknesses and guide the inclusion of sustainability-oriented policies in national budgets.
Life-history Trait Variation in Native vs. Invasive Asexual New Zealand Mud Snails
Authors: Donne Carina , Larkin Katelyn , Adrian-Tucci Claire , Good Abby , Kephart Carson , Neiman Maurine 
Published: August 2021

Abstract
Potamopyrgus antipodarum is a New Zealand freshwater snail that is invasive worldwide. While native P. antipodarum populations are characterized by frequent coexistence between obligately sexual and obligately asexual individuals, only the asexual snails are known to invade other ecosystems. Despite low genetic diversity and the absence of sex, invasive asexual P. antipodarum are highly successful. Here, we quantified variation in three key life-history traits across invasive P. antipodarum lineages and compared this variation to already documented variation in these same traits in asexual native lineages to provide a deeper understanding of why some lineages become invasive. In particular, we evaluated 1) if invasive lineages of P. antipodarum could be successful because they represent life-history variation from native ancestors that could facilitate invasion, and 2) if invasive populations with higher genetic variation would display relatively high phenotypic variation. We found that invasive snails displayed a non-representative sample of native diversity, with invasive snails growing more slowly and maturing more rapidly than their native counterparts. These results are consistent with expectations of a scenario where invasive lineages represent a subset of native variation that is beneficial in the setting of invasion. Nevertheless, there was no evidence for a relationship between genetic and phenotypic variation, indicating that increased genetic variation does not necessarily translate into greater phenotypic variation, and consistent with earlier studies suggesting an important role for phenotypic plasticity in the P. antipodarum invasion. Together, these results help illuminate the mechanisms driving the worldwide expansion of invasive populations of these snails.
Early Parenteral Amino Acid Supplementation Reduces the Risk of Neonatal Hyperkalemia in Preterm Infants: Single-Center Retrospective Study.
Authors: Suga Kenichi , Wakata Yoshifumi , Tanaka Manami , Takeuchi Shunsuke , Osumi Keita , Suzue Masashi , Nakagawa Ryuji , Kagami Shoji 
Published: August 2021

Abstract
The incidence of neonatal hyperkalemia in preterm infants was high in the early 2000s. However, the prevalence has declined recently, and the reason for the decline remains unclear. The development of neonatal hyperkalemia can be influenced by suppression of insulin secretion due to hypercatabolism; thus, early parenteral amino acid supplementation, which is now widespread for nutritional management for preterm infants, may have contributed to the decline. We conducted a single-center, retrospective cohort study with 225 preterm infants inborn between 240/7 and 316/7 weeks of gestation during 2009–2018. We compared the incidence of neonatal hyperkalemia between those with or without early parenteral amino acid supplementation (initiated within 24 h after birth). We included 150 infants with early AA supplementation from the first day of life and 75 controls. The incidence of neonatal hyperkalemia was significantly lower in the AA group than the control group (2.7% vs 12.4%, p<0.05). In multivariate analysis, the risk of hyperkalemia increased with delivery at <28 weeks and decreased with AA supplementation (adjusted odds ratio 0.11; 95% confidence interval 0.02–0.56, p<0.01). In conclusion, early AA supplement from the first day of life might have a prophylactic effect on neonatal hyperkalemia in preterm infants.
Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes
Authors: Frallicciardi Jacopo , Melcr Josef , Siginou Pareskevi , Marrink Siewert , Poolman Bert 
Published: August 2021

Abstract
Cell membranes provide a selective semi-permeable barrier to the passive transport of molecules. This property differs greatly between organisms. While the cytoplasmic membrane of bacterial cells is highly permeable for weak acids and glycerol, yeasts can maintain large concentration gradients. Here we show that such differences can arise from the physical state of the plasma membrane. By combining stopped-flow kinetic measurements with molecular dynamics simulations, we performed a systematic analysis of the permeability through synthetic lipid membranes to obtain detailed molecular insight into the permeation mechanisms. While membrane thickness is an important parameter for the permeability through fluid membranes, the largest differences occur when the membranes transit from the liquid-disordered to liquid-ordered and/or to gel state. By comparing our results with in vivo measurements from yeast, we conclude that the yeast membrane exists in a highly ordered and rigid state, which is comparable to synthetic saturated DPPC-sterol membranes.
Imaging protein conformational space in liquid water
Authors: Ruiz-Perez Lorena , Marchello Gabriele , De Pace Cesare , Acosta-Gutierrez Silvia , Ing Gabriel , Wilkinson Neil , Gervasio Francesco , Battaglia Giuseppe , Werner Finn , Pilotto Simona 
Published: August 2021

Abstract
Recent developments in electron-transparent materials have paved the way for liquid-phase electron microscopy (LPEM) leading to an unprecedented understanding of the structure and dynamics of specimens in their liquid environment. Image reconstruction in liquid-state poses several challenges, and most importantly, it undermines the single-particle analysis assumption that the three-dimensional objects captured on the image sensor are identical. We propose the combination of all-atom simulations with LPEM to complement structural studies with dynamic investigations. In this work, we exploited LPEM to image the dynamics of particles undergoing Brownian motion, using their natural rotation to access the particle structural landscape for reconstructing its architecture in 3D using tomographic techniques. We have selected two test cases for our approach according to prior data accessibility and physiological environment factors: apoferritin and archaeal RNA polymerase. We show that the adopted approach allows to achieve sub-nanometer spatial resolutions of protein structures, either imaging proteins one by one and assessing different conformational states or combining several proteins into one statistical conformational ensemble.
Analysis on Pregnancy Outcomes and Risk Factors of Cervical Polypectomy During the First and Second Trimester Pregnancy
Authors: Huang Yu-luan , Chen Rui-zhe , Le Fang 
Published: August 2021

Abstract
Purpose: To evaluate the risk factors of miscarriage in patients attempted cervical polypectomy during the first and second trimester pregnancy.Methods: Pregnant women with singleton infants who underwent cervical polypectomy during the first and second trimester between January 2013 to May 2019 were investigated. The study retrospectively reviewed the clinical features and pregnancy outcomes after cervical polypectomy. A multivariable regression was performed to predict the risk factors of miscarriage. Results: A total of 307 pregnant females were eventually included in our study. 27 patients (8.8%, 27/307) had a miscarriage before 28 weeks, 37 patients (12.1%, 37/307) had a preterm delivery. After univariate analysis, we found that the presence of decidual polyps and vaginal bleeding after polypectomy were the risk factors for miscarriage. Moreover, the incidence of miscarriage was significantly higher in the patients with decidual polyps than in those with endocervical polyps (14.9% vs.5.6%, p=0.010). Conclusion: The most suitable hemostasis method should be taken in the cervical polypectomy during pregnancy. The risk of miscarriage associated with polypectomy during pregnancy is higher in females with decidual polyps. If they do not cause excessive vaginal bleeding and can be ruled out the possibility of malignancy, conservative treatment may lead to a better outcome.
Outpatient Cardiovascular Diseases and Diabetes Medicines Dispensing in the Population with Government Health Insurance in Syria Between 2018-2019: A Retrospective Analysis.
Authors: Aljadeeah Saleh , Nagel Eckhard , Wirtz Veronika J. 
Published: August 2021

Abstract
Background:Low- and middle-income countries bear the highest burden of non-communicable diseases (NCDs) mortality and morbidity. Syria has undergone an epidemiological transition from infectious diseases to NCDs in the past decades. Despite the high prevalence of cardiovascular diseases (CVDs) and diabetes in Syria, little is known about medicines utilization or prescriptions for these diseases. The aims of this study are to present the patterns and rates of dispensing medicines used for CVDs and diabetes among patients with government health insurance in Syria and examine age, sex, and regional variation in the dispensing of these medicines.MethodsOutpatient data from June 2018 to May 2019 on dispensed medicines for 81,314 adults with government health insurance were obtained. The dispensing rate was expressed as the number of defined daily doses (DDDs) per 1,000 beneficiaries per day (DID). The number of DIDs was adjusted according to beneficiaries’ sex, age, and governorate.ResultsBeneficiaries received 337.75 DIDs of CVDs medicines and 35.66 DIDs of diabetes medicines, including 0.96 DID of insulin. CVDs and diabetes medicine dispensing rates were low during the study period and included very low rates of insulin dispensing. There were lower dispensing rates of CVDs and diabetes medicines among female beneficiaries. In addition, there were lower rates of CVDs and diabetes medicines and very low to no dispensing of insulin in some governorates that were only partly controlled by the Syrian government.ConclusionsAdditional efforts are needed to raise awareness about the prevention and management of CVDs and diabetes especially among females in Syria and consider cultural issues that might influence access to healthcare services. There is a crucial need to address the political and geographical challenges caused by the conflict which have limited access to CVDs and diabetes medicines in some regions in Syria.