bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Retail Outlet Health Kiosk Hypertension Trial (ROKHYT): Pilot Results
Authors: Shea Steven , Thompson John L P , Schwartz Joseph E , Chen Yineng , de Ferrante Morgan , Vanderbeek Alyssa M , Buchsbaum Richard , Vargas Celibell , Siddiqui Khan M , Moran Andrew E , Stockwell Melissa 
Published: August 2021

Abstract

BACKGROUND
Blood pressure (BP) control was only 43.7% in the National Health and Nutrition Survey (NHANES) survey in 2017–2018. Scalable, nonclinic-based strategies to control BP are needed. We therefore conducted a pilot trial of a text-messaging intervention in a national network of retail outlet health kiosks with BP devices. All study procedures were conducted remotely.

METHODS
Eligible individuals (N = 140), based on average BP greater than or equal to 140/90 mm Hg at kiosks during the prior year, were randomized to intervention vs. usual care. Intervention consisted of tailored text messages providing educational information with embedded links to educational videos on topics related to BP control. BP measurements were obtained at kiosks at 3, 6, and 12 months following randomization; control was defined as BP &lt; 140/90 mm Hg. Follow-up at 12 months was curtailed due to SARS-CoV-2. We therefore combined 12-month (N = 62) or carried forward 6-month (N = 61) data as the primary end point.

RESULTS
Participants were 51.4% male, 70.7% white/Caucasian, had mean age of 52.1 years, and mean baseline BP 145.5/91.8 mm Hg. At the end point, 37.7% intervention vs. 27.4% usual care subjects achieved BP control (difference, 10.3%, 95% confidence interval -6.2%, 26.8%). In an intention-to-treat analysis with multiple imputation of missing data, 12-month BP control was 29.0% vs. 19.8% favoring intervention (difference, 9.2%. 95% confidence interval -7.3%, 25.7%); intervention vs. control differences in adjusted mean BP levels were systolic BP: -5.4 mm Hg (95% confidence interval: -13.5, 2.7) and diastolic BP: +0.6 mm Hg (95% confidence interval: -4.2, 5.4).

CONCLUSIONS
These pilot results support the potential for a highly scalable text-messaging intervention to improve BP.

CLINICAL TRIALS REGISTRATION
Trial Number NCT03515681.
Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism
Authors: Motoyama Takayuki , Ishii Tomoaki , Kamakura Takashi , Osada Hiroyuki 
Published: August 2021

ABSTRACT
The control of secondary metabolism in fungi is essential for the regulation of various cellular functions. In this study, we searched the RIKEN Natural Products Depository (NPDepo) chemical library for inducers of tenuazonic acid (TeA) production in the rice blast fungus Pyricularia oryzae and identified NPD938. NPD938 transcriptionally induced TeA production. We explored the mode of action of NPD938 and observed that this compound enhanced TeA production via LAE1, a global regulator of fungal secondary metabolism. NPD938 could also induce production of terpendoles and pyridoxatins in Tolypocladium album RK99-F33. Terpendole production was induced transcriptionally. We identified the pyridoxatin biosynthetic gene cluster among transcriptionally induced secondary metabolite biosynthetic gene clusters. Therefore, NPD938 is useful for the control of fungal secondary metabolism.
mCNN-ETC: identifying electron transporters and their functional families by using multiple windows scanning techniques in convolutional neural networks with evolutionary information of protein sequences
Authors: Ho Quang-Thai , Le Nguyen Quoc Khanh , Ou Yu-Yen 
Published: August 2021

Abstract
In the past decade, convolutional neural networks (CNNs) have been used as powerful tools by scientists to solve visual data tasks. However, many efforts of convolutional neural networks in solving protein function prediction and extracting useful information from protein sequences have certain limitations. In this research, we propose a new method to improve the weaknesses of the previous method. mCNN-ETC is a deep learning model which can transform the protein evolutionary information into image-like data composed of 20 channels, which correspond to the 20 amino acids in the protein sequence. We constructed CNN layers with different scanning windows in parallel to enhance the useful pattern detection ability of the proposed model. Then we filtered specific patterns through the 1-max pooling layer before inputting them into the prediction layer. This research attempts to solve a basic problem in biology in terms of application: predicting electron transporters and classifying their corresponding complexes. The performance result reached an accuracy of 97.41%, which was nearly 6% higher than its predecessor. We have also published a web server on http://bio219.bioinfo.yzu.edu.tw, which can be used for research purposes free of charge.
Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use
Authors: Rabinowitz Jill A , Campos Adrian I , Ong Jue-Sheng , García-Marín Luis M , Alcauter Sarael , Mitchell Brittany L , Grasby Katrina L , Cuéllar-Partida Gabriel , Gillespie Nathan A , Huhn Andrew S , Martin Nicholas G , Thompson Paul M , Medland Sarah E , Maher Brion S , Rentería Miguel E 
Published: August 2021

AbstractGenome-wide association studies (GWAS) have identified genetic variants associated with brain morphology and substance use behaviors (SUB). However, the genetic overlap between brain structure and SUB has not been well characterized. We leveraged GWAS summary data of 71 brain imaging measures and alcohol, tobacco, and cannabis use to investigate their genetic overlap using linkage disequilibrium score regression. We used genomic structural equation modeling to model a “common SUB genetic factor” and investigated its genetic overlap with brain structure. Furthermore, we estimated SUB polygenic risk scores (PRS) and examined whether they predicted brain imaging traits using the Adolescent Behavior and Cognitive Development (ABCD) study. We identified 8 significant negative genetic correlations, including between (1) alcoholic drinks per week and average cortical thickness, and (2) intracranial volume with age of smoking initiation. We observed 5 positive genetic correlations, including those between (1) insula surface area and lifetime cannabis use, and (2) the common SUB genetic factor and pericalcarine surface area. SUB PRS were associated with brain structure variation in ABCD. Our findings highlight a shared genetic etiology between cortical brain morphology and SUB and suggest that genetic variants associated with SUB may be causally related to brain structure differences.
Remdesivir and Mortality in Patients With Coronavirus Disease 2019
Authors: Diaz George A , Christensen Alyssa B , Pusch Tobias , Goulet Delaney , Chang Shu-Ching , Grunkemeier Gary L , McKelvey Paul A , Robicsek Ari , French Tom , Parsons Guilford T , Doherty Glenn , Laurenson Charles , Roper Ryan , Hadlock Jennifer , Cover Cameron J , Footer Brent , Robinson Philip , Micikas Mary , Marfori Jennifer E , Cronenweth Charlotte , Mukkamala Yogavedya , Mackiewicz Jamie , Rai Ekra , Matson Martha Dickinson , Davila Jodie , Rueda Justin , Tipton Reda , Algren Heather , Ward Brittney C , Malkoski Stephen , Gluckman Tyler , Tallman Gregory B , Arguinchona Henry , Hammond Terese C , Standaert Steven , Christensen Joshua , Echaiz Jose F , Choi Robert , McClung Daniel , Pacifico Albert , Fee Martin , Sarafian Farjad , Berrington William R , Goldman Jason D 
Published: August 2021

Abstract

Background
The impact of remdesivir (RDV) on mortality rates in coronavirus disease 2019 (COVID-19) is controversial, and the mortality effect in subgroups of baseline disease severity has been incompletely explored. The purpose of this study was to assess the association of RDV with mortality rates in patients with COVID-19.

Methods
In this retrospective cohort study we compared persons receiving RDV with those receiving best supportive care (BSC). Patients hospitalized between 28 February and 28 May 2020 with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection were included with the development of COVID-19 pneumonia on chest radiography and hypoxia requiring supplemental oxygen or oxygen saturation ≤94% with room air. The primary outcome was overall survival, assessed with time-dependent Cox proportional hazards regression and multivariable adjustment, including calendar time, baseline patient characteristics, corticosteroid use, and random effects for hospital.

Results
A total of 1138 patients were enrolled, including 286 who received RDV and 852 treated with BSC, 400 of whom received hydroxychloroquine. Corticosteroids were used in 20.4% of the cohort (12.6% in RDV and 23% in BSC). Comparing persons receiving RDV with those receiving BSC, the hazard ratio (95% confidence interval) for death was 0.46 (.31–.69) in the univariate model (P &lt; .001) and 0.60 (.40–.90) in the risk-adjusted model (P = .01). In the subgroup of persons with baseline use of low-flow oxygen, the hazard ratio (95% confidence interval) for death in RDV compared with BSC was 0.63 (.39–1.00; P = .049).

Conclusion
Treatment with RDV was associated with lower mortality rates than BSC. These findings remain the same in the subgroup with baseline use of low-flow oxygen.
Elucidation of the speciation history of three sister species of crown-of-thorns starfish (Acanthaster spp.) based on genomic analysis
Authors: Yuasa Hideaki , Kajitani Rei , Nakamura Yuta , Takahashi Kazuki , Okuno Miki , Kobayashi Fumiya , Shinoda Takahiro , Toyoda Atsushi , Suzuki Yutaka , Thongtham Nalinee , Forsman Zac , Bronstein Omri , Seveso Davide , Montalbetti Enrico , Taquet Coralie , Eyal Gal , Yasuda Nina , Itoh Takehiko 
Published: August 2021

Abstract
The crown-of-thorns starfish (COTS) is a coral predator that is widely distributed in Indo-Pacific Oceans. A previous phylogenetic study using partial mitochondrial sequences suggested that COTS had diverged into four distinct species, but a nuclear genome-based analysis to confirm this was not conducted. To address this, COTS species nuclear genome sequences were analysed here, sequencing Northern Indian Ocean (NIO) and Red Sea (RS) species genomes for the first time, followed by a comparative analysis with the Pacific Ocean (PO) species. Phylogenetic analysis and ADMIXTURE analysis revealed clear divergences between the three COTS species. Furthermore, within the PO species, the phylogenetic position of the Hawaiian sample was further away from the other Pacific-derived samples than expected based on the mitochondrial data, suggesting that it may be a PO subspecies. The pairwise sequentially Markovian coalescent model showed that the trajectories of the population size diverged by region during the Mid-Pleistocene transition when the sea-level was dramatically decreased, strongly suggesting that the three COTS species experienced allopatric speciation. Analysis of the orthologues indicated that there were remarkable genes with species-specific positive selection in the genomes of the PO and RS species, which suggested that there may be local adaptations in the COTS species.
Long-term neurodevelopment in children born with esophageal atresia: a systematic review
Authors: van Hoorn Camille E , ten Kate Chantal A , Rietman Andre B , Toussaint-Duyster Leontien C C , Stolker Robert Jan , Wijnen Rene M H , de Graaff Jurgen C 
Published: August 2021

Summary

Background
Although the survival rate of esophageal atresia (EA) has increased to over 90%, the risk of functional long-term neurodevelopmental deficits is uncertain. Studies on long-term outcomes of children with EA show conflicting results. Therefore, we provide an overview of the current knowledge on the long-term neurodevelopmental outcome of children with EA.

Methods
We performed a structured literature search in Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google scholar on November 8, 2020 with the keywords ‘esophageal atresia’, ‘long-term outcome’, ‘motor development’, ‘cognitive development’, and ‘neurodevelopment’.

Results
The initial search identified 945 studies, of which 15 were included. Five of these published outcomes of multiple tests or tested at multiple ages. Regarding infants, one of six studies found impaired neurodevelopment at 1 year of age. Regarding preschoolers, two of five studies found impaired neurodevelopment; the one study assessing cognitive development found normal cognitive outcome. Both studies on motor function reported impairment. Regarding school-agers, the one study on neurodevelopmental outcome reported impairment. Cognitive impairment was found in two out of four studies, and motor function was impaired in both studies studying motor function.

Conclusions
Long-term neurodevelopment of children born with EA has been assessed with various instruments, with contrasting results. Impairments were mostly found in motor function, but also in cognitive performance. Generally, the long-term outcome of these children is reason for concern. Structured, multidisciplinary long-term follow-up programs for children born with EA would allow to timely detect neurodevelopmental impairments and to intervene, if necessary.
Bumblebees Exposed to a Neonicotinoid Pesticide Make Suboptimal Foraging Decisions
Authors: Siviter Harry , Johnson Anthony K , Muth Felicity 
Published: August 2021

Abstract
Bumblebees are important pollinators of agricultural crops and wildflowers, but many species are in decline. Neonicotinoid insecticides are the most commonly used insecticide globally and can have negative sublethal effects on bumblebee colony growth and reproduction. Individual bumblebees can visit hundreds to thousands of flowers a day to forage for their colony. As such, they are a model species for studying optimal foraging, and small impairments to an individual’s foraging decisions may have compounding effects on the colony’s nutritional intake. We exposed bumblebees (Bombus impatiens) to an acute, field-realistic dose of the neonicotinoid insecticide imidacloprid, before allowing them to forage on an artificial floral array. We found that neonicotinoid-exposed bumblebees made suboptimal foraging decisions, as they were more likely to visit flowers located further apart than control bees. This indicates that for a given flower patch, individual bees exposed to a neonicotinoid will likely use more energy and forage less efficiency than unexposed bees, although further studies that directly measure energetic cost are required to confirm this. Given the robust and growing body of evidence demonstrating negative sublethal effects of neonicotinoids on bees, sublethal assessments on non-Apis bees should be made mandatory within the regulatory process.
Risk factors for type 1 and type 2 myocardial infarction
Authors: Wereski Ryan , Kimenai Dorien M , Bularga Anda , Taggart Caelan , Lowe David J , Mills Nicholas L , Chapman Andrew R 
Published: August 2021

Abstract

Aims
Whilst the risk factors for type 1 myocardial infarction due to atherosclerotic plaque rupture and thrombosis are established, our understanding of the factors that predispose to type 2 myocardial infarction during acute illness is still emerging. Our aim was to evaluate and compare the risk factors for type 1 and type 2 myocardial infarction.

Methods and results
We conducted a secondary analysis of a multi-centre randomized trial population of 48 282 consecutive patients attending hospital with suspected acute coronary syndrome. The diagnosis of myocardial infarction during the index presentation and all subsequent reattendances was adjudicated according to the Universal Definition of Myocardial Infarction. Cox regression was used to identify predictors of future type 1 and type 2 myocardial infarction during a 1-year follow-up period. Within 1 year, 1331 patients had a subsequent myocardial infarction, with 924 and 407 adjudicated as type 1 and type 2 myocardial infarction, respectively. Risk factors for type 1 and type 2 myocardial infarction were similar, with age, hyperlipidaemia, diabetes, abnormal renal function, and known coronary disease predictors for both (P &lt; 0.05 for all). Whilst women accounted for a greater proportion of patients with type 2 as compared to type 1 myocardial infarction, after adjustment for other risk factors, sex was not a predictor of type 2 myocardial events [adjusted hazard ratio (aHR) 0.82, 95% confidence interval (CI) 0.66–1.01]. The strongest predictor of type 2 myocardial infarction was a prior history of type 2 events (aHR 6.18, 95% CI 4.70–8.12).

Conclusions
Risk factors for coronary disease that are associated with type 1 myocardial infarction are also important predictors of type 2 events during acute illness. Treatment of these risk factors may reduce future risk of both type 1 and type 2 myocardial infarction.
Quality of life and family function are poorest when both patients with heart failure and their caregivers are depressed
Authors: Liljeroos Maria A , Miller Jennifer L , Lennie Terry A , Chung Misook L 
Published: August 2021

Abstract

Aims
Patients with heart failure (HF) and their family caregivers commonly experience depressive symptoms associated with low quality of life (QOL) at the individual level. However, there is a lack of knowledge about how QOL and family function are associated with depressive symptoms at the dyad level. The aim of this article is to compare QOL and family function among dyads stratified by depressive symptoms.

Methods and results
Outpatients with HF and their primary caregivers completed the Beck Depression Inventory-II for depressive symptoms, the Short Form 36 for physical and mental QOL, and the McMaster Family Assessment Device for a family function. Analysis of variance was used to compare QOL and family function among the four dyad groups. A total of 91 dyads were categorized into four groups: neither member having depressive symptoms (43.9%), only the caregiver having depressive symptoms (13.2%), only the patient having depressive symptoms (23.1%), and both members having depressive symptoms (20.9%). Dyads without depressive symptoms had the highest levels of physical and mental QOL among the groups. The dyads with both members having depressive symptoms had the lowest levels of physical and mental QOL (P &lt; 0.001) and the lowest levels of general family functioning, problem-solving ability, and communication ability (P &lt; 0.001). Intermediate levels of QOL were seen in dyads with only one member having depressive symptoms, and a similar pattern of intermediate scores was found in all three subscales of family function.

Conclusion
Dyads with both members having depressive symptoms may be at greatest risk of having poor QOL and low family functioning.
Olfactory Stimulation Successfully Improves Swallowing Function of Aged Rats Through Activating Central Neuronal Networks and Downstream DHPR–RyR-mediated Neuromuscular Activities
Authors: Chen Yea-Tzy , Chen Li-You , Renn Ting-Yi , Cheng Meng-Shan , Wang Chi-Te , Klimenkov Igor V , Sudakov Nikolay P , Liao Wen-Chieh , Chen Yea-Jyh , Chang Hung-Ming 
Published: August 2021

Abstract
Presbyphagia is age-related changes in swallowing function, which imposes a high risk of aspiration in older adults. Considering olfactory stimulation (OS) can influence behavioral activities by modulating neuronal excitability, the present study aims to determine whether OS could improve the swallowing function of aged rats through activating the central neuronal networks and downstream muscular activities participated in the control of swallowing. Aged male Wistar rats received OS by inhaling a mixture of plant-based volatile molecules twice a day for 12 days were subjected to functional magnetic resonance imaging (fMRI) and c-fos, choline acetyltransferase (ChAT) immunostaining to detect the neuronal activities of the orbitofrontal cortex (OFC) and medullary nuclei engaged in swallowing control, respectively. The functional effects of OS on downstream pharyngeal muscle activity were examined by evaluating the dihydropyridine receptor–ryanodine receptor (DHPR–RyR)-mediated intramuscular Ca2+ expression, and analyzing the amplitude/frequency of muscle contraction, respectively. In untreated rats, only moderate signal of fMRI and mild c-fos/ChAT expression was detected in the OFC and medullary nuclei, respectively. However, following OS, intense signals of fMRI and immunostaining were clearly expressed in the orbitofronto-medullary networks. Functional data corresponded well with above findings in which OS significantly enhanced DHPR–RyR-mediated intramuscular Ca2+ expression, effectively facilitated a larger amplitude of pharyngeal muscle contraction, and exhibited better performance in consuming larger amounts of daily dietary. As OS successfully activates the neuromuscular activities participated in the control of swallowing, applying OS may serve as an effective, easy, and safe strategy to greatly improve the swallow function of aging populations.
A fast sweeping method for calculating qP-wave traveltimes in 3-D vertical transversely isotropic media using a quadratic equation
Authors: Lu Yongming , Zhang Wei 
Published: August 2021

SUMMARY
Traveltime computations are an important aspect of seismic data processing applications such as traveltime tomography, migration and seismic source localization. Seismic anisotropy is a widespread feature of the Earth. Solutions to the eikonal equation that account for such anisotropy are needed for high-resolution seismic imaging and inversion. The fast sweeping method (FSM) has been widely used in computing the first-arrival traveltimes for anisotropic media because it does not need to expand the wave front from the point of the smallest traveltime. To apply FSM on strong anisotropic media, one has to solve the slowness equation derived from the Christoffel equation. All the previous developed FSM methods transform the quartic coupled slowness surface equation of quasi-P (qP) and quasi-SV (qSV) waves to the quartic equation in terms of the unknown traveltime, then numerically solve this quartic equation to compute the first-arrival traveltimes of the qP waves. However, the computational cost is significantly increased due the numerically solving the quartic equation, especially for the 3-D problems. In this study, we find a way to transform the quartic slowness equation into a quadratic one if a specific triangular-pyramid stencil around a target point is used. As the quadratic equation has the analytical solution and does not need a numerical solver, the computational efficiency of the scheme is greatly improved. We apply this methodology to develop an efficient 3-D FSM to compute the first-arrival traveltimes for qP waves in 3-D vertical transversely isotropic (VTI) media. We use both layered VTI model and complex VTI model to demonstrate the efficiency of the proposed method to obtain accurate traveltimes in 3-D VTI media involving strong anisotropy.