bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histomorphological spectrum of intracranial space occupying lesions: Experience at tertiary care centre
Authors: Meshram Saroj A , Kinkhede Devika S , Parate Sanjay N , Kumbhalkar Dinkar T , Tathe Shilpa P , Randale Archana A 
Published: November 2021

An “Intra-cranial space occupying lesion” (ICSOL) is defined as a mass in the cranial cavity with a diverse etiology like benign or malignant neoplasm, inflammatory or parasitic lesion, haematoma or arterio-venous malformation. The aim was to study the histomorphological spectrum of intracranial space occupying lesions at a tertiary care centre hospital in order to give accurate pretherapeutic diagnosis to facilitate better therapeutic results. This prospective and descriptive type of study of two years duration was carried out from November 2017 to October 2019 in Govt. Medical College and Superspeciality Hospital, Nagpur in the Department of Pathology. A total of 300 samples were received from Department of Neurosurgery. Detailed collection of clinical data was done in all patients regarding age, sex, clinical symptoms and radiological findings.The samples were received in 10% formalin and subjected to routine histopathological processing. Slides prepared were stained with hematoxylin and eosin stain. Special stains were done wherever required. Total 300 cases were studied of which 261 cases (87%) were neoplastic in nature and 39 cases (13%) were non neoplastic. Amongst primary tumours, most common were gliomas (48%) followed by meningiomas (20%) and schwannomas (9%). ICSOLs can present with nonspecific clinical features. Radio diagnostic investigations are helpful adjunct tools but cannot give exact diagnosis. Histopathological examination remains a gold standard for diagnosing and grading of tumours on which basis clinician can decide further line of management.
Histopathologic pattern of ovarian masses in Usmanu Danfodiyo university teaching hospital, Sokoto, Nigeria
Authors: Bello Usman , Gambo Umar Amina , Ibrahim Hassan , Abbas Aminu , Haruna Muhammad S , Mohammed Umar , Salihu Aliyu 
Published: November 2021

Diseases of the ovary are diversely arising from the different parenchymal tissue components. This span between reactive functional cysts to more debilitating ovarian carcinoma. Ovarian carcinoma is the sixth most common cancer and one of the leading cause of cancer death among female. This study aims to determine the epidemiological and histopathological patterns of ovarian masses in our setting.The study material was all the ovarian tissues biopsy specimen submitted to the Department of Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto over five years. These were fixed in 10% formal saline embedded in paraffin wax, tissue blocks formed and were sections and stained with hematoxylin and eosin on the glass slides. Request cards and case folders were used to extract clinical information. These were reviewed, analysed and presented as frequency distribution figures.There were 112 ovarian biopsies during the study period. Their ages ranged between 13 and 67 years and peaked in the fourth decade of life. Fifty per cent of all the cases were seen between the ages of 21 and 40 years. Benign neoplastic diseases formed 50% of the ovarian masses and matured cystic teratoma was the most common. Others were reactive and functional ovarian cysts (24.1%), malignant neoplastic conditions (14.3%) and inflammatory / infectious diseases (11.6%). Overall mature cystic teratoma constitutes 27% of the entire ovarian masses. Matured cystic teratoma was the most common disease of the ovary in our setting, afflicting young female, while malignant tumours dominated by serous cystadenocarcinoma affect the older age group. The fourth decade of life was the most common age of affectation. We advocate for proper histopathologic evaluation of all ovarian masses to arrive at a definitive diagnosis to offer an appropriate treatment modality.
El Derecho Cooperativo en la postpandemia
Authors: Cracogna Dante 
Published: November 2021

Sumario: 1. Proemio.—2.—¿Qué dejará la pandemia?—3. La respuesta cooperativa.—4. Papel del derecho cooperativo: a) Fortalecer la identidad cooperativa; b) Eliminar trabas; c) Reconocer la contribución cooperativa.—5. Conclusiones.—Bibliografía.
La legislación cooperativa en Argentina
Authors: Cracogna Dante 
Published: November 2021

El artículo describe sintéticamente el régimen legal de las cooperativas en Argentina comenzando por sus antecedentes históricos a partir del Código de Comercio de 1889 y un planteo general de la ley vigente en la materia. Seguidamente se exponen los principales institutos jurídicos siguiendo la estructura de la Ley 20.337 y poniendo énfasis en aquéllos que distinguen claramente a las cooperativas de otras formas jurídicas de organización colectiva. Se analiza la incidencia del Código Civil y Comercial que rige a partir de 2015 sobre la legislación cooperativa como así también la aplicación supletoria de las disposiciones sobre sociedades anónimas contenidas en la Ley General de Sociedades. Especial atención merecen la caracterización de las cooperativas, el acto cooperativo, el régimen económico, los órganos sociales y la integración cooperativa.
Recibido: 22 junio 2021Aceptado: 06 septiembre 2021
Pemanfaatan Tumbuhan Teratai (Nymphaea) di Desa Tambak Baru Ilir, Martapura, Kabupaten Banjar
Authors: Yuniar Herlina , Kuntorini Evi Mintowati , Sari Sasi Gendro 
Published: November 2021

Lotus, classified as Nymphaea, is hydrophyte plant with high potencies. The aim of the study is to discover the utilization and processing of lotus plant, and to determine the secondary metabolite of Nymphaea pubescens Willd. and N. nouchali Brum F. The methods used were by doing survey and direct interview with semi-structural technic by fulfilling questionnaire data. Selection of respondents was done by simple random sampling method. Sample taking was done by purposive sampling which considered the sample existence that could represent those lotus plants. The results showed that the utilization of N. pubescens is mostly around 47% by boiling, pounding, and sauteing them meanwhile the utilization of N. nouchali Brum F is mostly around 73% by boiling and sauteing them. Parts of the lotus plant used are seed and stem. Leaves of N. pubescens are used for healing dysentery by making them for drink. Seeds of N. pubescens have potencies in increasing functions of heart and lymph, improving stamina, anti-aging, curing diarrhea, and desentery.
Percutaneous Forefoot Decompression in a Foot Compartment Syndrome Model
Authors: Schupbach Drew E. , Nasser Eddine Mohamad , Honjol Yazan , Merle Geraldine , Harvey Edward J. 
Published: November 2021

Background:
Acute compartment syndrome of the foot is a controversial topic. Release of the foot has been seen as complicated because of large incisions and postoperative morbidity, and there has been debate over whether this procedure is actually effective for releasing all areas of increased pressure. New sensor technology affords the opportunity to advance our understanding of acute compartment syndrome of the foot and its treatment. The purpose of the present study was to determine whether percutaneous decompression could be performed for the treatment of compartment syndrome in a forefoot model.

Methods:
The present study utilized a validated continuous pressure sensor to model compartment syndrome in human cadaveric feet. We utilized a pressure-controlled saline solution infusion system to induce increased pressure. A novel percutaneous release of the forefoot was investigated to assess its efficacy in achieving decompression.

Results:
For all cadaveric specimens, continuous pressure monitoring was accomplished with use of a continuous pressure sensor. There were 4 discrete compartment areas that could be reliably pressurized in all feet. The average baseline, pressurized, and post-release pressures (and standard deviations) were 4.5 ± 2.9, 43.8 ± 7.7, and 9.5 ± 3.6 mm Hg, respectively. Percutaneous decompression produced a significant decrease in pressure in all 4 compartments (p < 0.05).

Conclusions:
With use of continuous compartment pressure monitoring, 4 consistent areas were established as discrete compartments in the foot. All 4 compartments were pressurized with a standard pump system. With use of 2 small dorsal incisions, all 4 compartments were successfully released, with no injuries identified in the cutaneous nerve branches, extensor tendons, or arteries. These results have strong implications for the future of modeling compartment syndrome as well as for guiding clinical studies.

Clinical Relevance:
A reproducible and accurate method of continuous pressure monitoring of foot compartments after trauma is needed (1) to reliably identify patients who are likely to benefit from compartment release and (2) to help avoid missed or evolving cases of acute compartment syndrome. In addition, a reproducible method for percutaneous compartment release that minimizes collateral structural damage and the need for secondary surgical procedures is needed.
Identification of Potential Biomarkers For The Prognosis, Diagnosis, And Targeted Therapy in Kidney Renal Clear Cell Carcinoma
Authors: Cheng Fang , Li Qiang , Wang Jinglin , Wang Yumei , Wang Zhendi , Zeng Fang , Zhang Yu 
Published: November 2021

Abstract
Background: Kidney renal clear cell carcinoma (KIRC) is the most common renal cell carcinoma types. This work aims to find potential diagnostic biomarkers and explore the biological functions related to the prognosis of KIRC. Method: First, Gene expression profiles of GSE15641, GSE72304, GSE71963, GSE53757, and GSE36895 from GEO database. Differentially expressed genes (DEGs) were identified by the limma package in R software. Next, gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis were performed. Then protein-protein interaction (PPI) and hub genes were visualized by Cytoscape with STRING database. Then, we evaluate the predictive potential of hub genes expressions in KIRC with TCGA data. In addition, the relevant biological functions were identified using GSEA. Finally, we examined the differences of hub genes expression between multiple tumor tissues and normal tissues.Results: A total of 141 DEGs (including 99 upregulated and 42 downregulated genes) were identified. GO analysis indicated that DEGs were mainly involved in oxidation-reduction process and response to hypoxia. The KEGG analysis primarily related to PPAR signaling pathway, and HIF-1 signaling pathway. Moreover, the PPI analysis revealed 5 hub genes (AOX1, ALDH6A1, ABAT, HADH, and PCCA). The 5 hub genes were significantly correlated with KIRC progression and might have prognostic significance for KIPC patients. And low expression of the hub genes associated biological pathways were enriched in the NF-KB activation, focal adhesion, and JAK-STAT signaling pathway, respectively. Conclusion: Our study demonstrated that AOX1, ALDH6A1, ABAT, HADH, and PCCA can be used as prognostic biomarkers for KIRC.
Post-Treatment of Kennel Wastewater With Different Aeration Strategies
Authors: Souza Aline dos Reis , de Matos Mateus Pimentel , Siniscalchi Luciene Alves Batista , Fia Ronaldo 
Published: November 2021

Abstract
The objective of this study was to evaluate the effect of the introduction of a complementary aerobic treatment composed of a submerged aerated biological filter (SABF) with a secondary clarifier (SC), followed by horizontal subsurface flow constructed wetlands (CWs), after anaerobic units, on the ability to remove pollutants in different aeration phases (Ph1, Ph2, and Ph3) at the effluent treatment station of the Parque Francisco de Assis (PFA) dog shelter. Ph1 and Ph2 had 7 and 5 hours of daily aeration, respectively, and Ph3 had intermittent aeration every 2 hours. The phases were monitored regarding the removal efficiency of organic matter, solids, nutrients (N, P), coliforms, and detection of Giardia and Cryptosporidium. It was found that post-treatment provided greater removal efficiencies and that the aeration strategy of Ph3 showed mean efficiencies of 71% for COD removal and 77% for BOD removal, being similar or statistically higher, even with less biodegradable effluent, than those of Ph1 and Ph2. The SABF and SC removed N by nitrification and denitrification, leaving a total Kjeldahl nitrogen (TKN) concentration in the effluent of 18 mg L−1. The CW showed potential for simultaneous nitrification and denitrification (SND), in addition to solid filtration. The system did not satisfactorily remove thermotolerant coliforms (ThermC) (1 ± 0 log). PCR suggested the presence of the pathogens Giardia and Cryptosporidium in all post-treatment units in Ph1 and Ph2.
Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington’s disease
Authors: Surmeier Dalton , Pancani Tristano , Day Michelle , Tkatch Tatiana , Wokosin David , Rodriguez Patricia Gonzalez , Kondapalli Jyothisri , Chen Yu , Beaumont Vahri 
Published: November 2021

Abstract
Huntington’s disease (HD) is a progressive, neurodegenerative disease caused by a CAG triplet expansion in the huntingtin gene. Although corticostriatal dysfunction has long been implicated in HD, the determinants and pathway specificity of this pathophysiology remain a matter of speculation. To help fill this gap, the zQ175+/- knockin mouse model of HD was studied using approaches that allowed optogenetic interrogation of intratelencephalic (IT) and pyramidal tract (PT) connections with principal striatal spiny projection neurons (SPNs). These studies revealed that the connectivity of IT, but not PT, neurons with direct and indirect pathway SPNs increased in early symptomatic zQ175+/- HD mice. This enhancement was attributable to reduced inhibitory control of IT terminals by striatal cholinergic interneurons (ChIs). Lowering mutant huntingtin selectively in ChIs with a virally-delivered zinc finger repressor protein normalized striatal acetylcholine release and IT functional connectivity – revealing a novel node in the network underlying corticostriatal pathophysiology in HD.
A novel IL-10 – DEL-1 axis promotes granulopoiesis and sepsis survival in early life
Authors: Vergadi Eleni , Kolliniati Ourania , Lyroni Konstantina , Ieronymaki Eleftheria , Lapi Ioanna , Alexaki Vasileia , Diamantaki Eleni , Vaporidi Katerina , Hatzidaki Eleftheria , Papadaki Helen , Chavakis Triantafyllos , Galanakis Emmanouil , Hajishengallis George , Tsatsanis Christos 
Published: November 2021

Abstract
Newborns’ susceptibility to infection is mainly attributed to decreased neutrophil bone marrow reserves and peripheral blood neutropenia. However, the regulation of neonatal neutrophil kinetics in sepsis remains poorly understood. We demonstrate herein that the developmental endothelial locus (DEL-1) is elevated in early life and is integral to a protective host response in neonates, by supporting emergency granulopoiesis. DEL-1-deficient neonate mouse pups subjected to sepsis displayed diminished bone marrow numbers of neutrophils and granulocyte-macrophage progenitors, leading to neutropenia, exaggerated bacteremia, and increased mortality; defects that were rescued by DEL-1 administration. Contrary to adult mice, DEL-1 was not downregulated upon neonatal sepsis. The sustained production of DEL-1 under newborn sepsis was attributed to a high IL-10/IL-17A ratio, as we IL-10 upregulated DEL-1. The expression of DEL-1 and its effect in emergency granulopoiesis in neonates was diminished by anti-IL-10-Receptor blockage. Consistent with the mouse findings, DEL-1 and neutrophil numbers were higher in septic human adult and neonate patients with high IL-10/IL-17A ratio. Furthermore, septic patients with high DEL-1 exhibited lower mortality rates compared to patients with low DEL-1. These findings highlight the role of a hitherto unappreciated IL-10–DEL-1 axis in supporting emergency granulopoiesis, preventing neutropenia and promoting sepsis survival in early life.
Diagnosis and Classification of Alzheimer's Disease by Using a Convolution Neural Network Algorithm
Authors: Al-Adhaileh Mosleh Hmoud 
Published: November 2021

Abstract
Alzheimer's disease (AD) is a high-risk and atrophic neurological illness that slowly and gradually destroys brain cells (i.e. neurons). As the most common type of amentia, AD affects 60–65% of all people with amentia and poses major health dangers to middle-aged and elderly people. For classification of AD in the early stage, classification systems and computer-aided diagnostic techniques have been developed. Previously, machine learning approaches were applied to develop diagnostic systems by extracting features from neural images. Currently, deep learning approaches have been used in many real-time medical imaging applications. In this study, two deep neural network techniques, AlexNet and Restnet50, were applied for the classification and recognition of AD. The data used in this study to evaluate and test the proposed model included those from brain magnetic resonance imaging (MRI) images collected from the Kaggle website. A convolutional neural network (CNN) algorithm was applied to classify AD efficiently. CNNs were pre-trained using AlexNet and Restnet50 transfer learning models. The results of this experimentation showed that the proposed method is superior to the existing systems in terms of detection accuracy. The AlexNet model achieved outstanding performance based on five evaluation metrics (accuracy, F1 score, precision, sensitivity and specificity) for the brain MRI datasets. AlexNet displayed an accuracy of 94.53%, specificity of 98.21%, F1 score of 94.12% and sensitivity of 100%, outperforming Restnet50. The proposed method can help improve CAD methods for AD in medical investigations.
The “common” experience of voice-hearing and its relationship with shame and guilt: a systematic review
Authors: Volpato Eleonora , Cavalera Cesare , Castelnuovo Gianluca , Molinari Enrico , Pagnini Francesco 
Published: November 2021

Abstract
Background
Despite Auditory Verbal Hallucinations (AVHs) have been long associated with mental illness, they represent a common experience also in the non-clinical population, yet do not exhibit distress or need for care.
Objectives
This paper aims to provide a systematic review of studies that investigated the relationship between auditory hallucinations, shame, and guilt in people without relevant signs of psychiatric issues.
Methods
We searched studies reporting information about voices characteristics, the relationship between voices and hearers, hearer's reactions, and beliefs (1946-2021) and those that explored the differences between “patients” and “non-patients”, paying peculiar attention to shame and guilt issues. Included papers were evaluated for risk of bias.
Results
Eleven studies that explored the relationship between AVHs, shame and guilt, were extracted. Phenomenological, pragmatic, as well as neuropsychological features of hearing voices in non-clinical populations, allowed us to note a dynamic relationship and the constellation of subjective experiences that can occur. The role of guilt was characterized by few studies and mixed results, while shame was mainly common.
Conclusions
Due to the high heterogeneity detected and the scarce sources available, further studies should focus on both the aetiology and the bidirectional relationship between hearing voices, shame, and guilt in non-clinical people. This might favour the development and implication of different treatments considering emotion regulation, distress tolerance and interpersonal sensitivity on the other people.
Pro-Vaccination Attitude and Associated Factors Towards COVID-19 Vaccine among Healthcare Workers and Nonhealthcare Workers: “A Call for Action”-A Systematic Review
Authors: Wake Addisu 
Published: November 2021

Abstract
Introduction: Coronavirus disease 2019 (COVID-19) pandemic hasn’t been managed and controlled effectively, globally. The aim of this systematic review was to determine Pro-vaccination attitude and associated factors towards COVID-19 vaccine among healthcare workers (HCWs) and nonhealthcare workers (non-HCWs).Methods: Different databases such as PsycINFO, HINARI, Cochrane Library, PubMed, EMBASE, African Journals OnLine, Web of Science, Scopus, and Google Scholar for the related articles. Result: The levels of positive attitude towards COVID-19 vaccine among HCWs was ranged from 21% to 95%. Factors significantly associated with the attitude towards COVID-19 vaccine among HCWs were such as age, gender, race, work experience, home location, having no fear of injections, being a non-smoker, profession, presence of chronic illnesses, allergies, confidence in pharmaceutical companies, history of taking influenza vaccine, vaccine recommendation, perceived risk of new vaccines, perceived utility of vaccine, receiving a seasonal flu vaccination in the last 5 years, working in a private hospital, a high perceived pandemic risk index, low vaccine harm index, high pro-socialness index, being in close contact with a high-risk group, knowledge about the virus, confidence in and expectations about personal protective equipment and behaviors. The levels of positive attitude towards COVID-19 vaccine among non-HCWs was ranged from 21.4% to 91.99%. Factors associated with the attitude towards COVID-19 vaccine among non-HCWs were such as age, gender, educational level, occupation, marital status, residency, income, ethnicity, risk for severe course of COVID-19, direct contact with COVID-19 at work, being a health profession, being vaccinated against seasonal flu, perceived benefits, cues to actions, having previous history of vaccination, fear of passing on the disease to relatives, and the year of medical study, studying health-related courses, COVID-19 concern, adherence level to social distancing guidelines, history of chronic disease, being pregnancy, perceived vaccine safety, having more information about vaccine effectiveness, mandatory vaccination, being recommended to be vaccinated, lack of the confidence in the healthcare system to control epidemic, and believe in COVID-19 vaccines protection from COVID-19 infection. Conclusion: The level of positive attitude towards COVID-19 vaccine among both HCWs and non-HCWs were unfavorable and comparable. Globally, there is a need for a call for action to cease the time and crisis of this pandemic.