bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of D‐Tetramethrin on Zebrafish Development and Immune System
Authors: Li Yang , Zhong Keyuan , Zhang Sijie , Duan Shiyi , Huang Kaijie , Che Xiaofang , Guo Xinchun , Lu Huiqiang 
Published: February 2025

ABSTRACTD‐tetramethrin is a common insecticide that is important for the control of mosquito‐transmitted diseases such as malaria and dengue and, due to its widespread use, it is frequently detected in environmental systems. However, there is currently very little information on the influence of D‐tetramethrin on non‐target organisms. In this study, zebrafish embryos were exposed to various concentrations of D‐tetramethrin (0, 3, 6, and 9 mg/L) from 6 to 72 h past fertilization (hpf) to ascertain the influence of D‐tetramethrin on the zebrafish immune system and development. We found that D‐tetramethrin exposure led to a significant decrease in heart rate, an increase in the yolk area and tail flick frequency, and a shortening of body length in zebrafish larvae, compared with the control group. The number of macrophages and neutrophils in the experimental group of zebrafish larvae decreased significantly and the oxidative stress levels increased compared with the control group. The malondialdehyde (MDA) content and reactive oxygen species (ROS) content increased significantly, while catalase (CAT) activity increased and superoxide dismutase (SOD) activity decreased in the experimental group. At the same time, apoptosis increased in the zebrafish embryo cells, and the expression of apoptosis‐related genes such as p53, Bax, and Bcl‐2 was abnormal. Moreover, the pro‐inflammatory genes IL‐8, IFN‐γ, IL‐6, and TNF‐α were up‐regulated, while the anti‐inflammatory gene, IL‐10, was down‐regulated. Therefore, D‐tetramethrin significantly affects the immune system and oxidative stress levels in zebrafish, inducing cell apoptosis and negatively affecting embryo development. These results provide novel data for the toxicity of D‐tetramethrin and the potential adverse effects of environment residues.
Patient experiences of crisis home treatment teams: a systematic review and thematic synthesis
Authors: Yang Jialin , Glover Naomi , Wood Lisa 
Published: February 2025

Abstract

Purpose
Crisis home treatment teams (CHTTs) provide rapid at-home assessments and crisis support to individuals experiencing mental health crises. Exploring patient feedback on CHTTs can provide policymakers and service planners useful insight regarding service enhancements and improvements in care quality. The current systematic review aims to explore patient experiences on CHTTs, to inform policy decision-making and care quality.

Method
The current review synthesised ten eligible qualitative studies (from Medline, PsycINFO, Embase and CINAHL) on patient experiences of CHTTs using thematic synthesis. Adult patients with a past or current experience of CHTTs, as well as a mental health diagnosis were included in the review.

Results
The current review revealed that patients valued the rapid accessibility of services and positive characteristics of staff that contributed to cultivating strong therapeutic relationships. Patients also appreciated having equal power in treatment decision-making. However, concerns were raised regarding staff timekeeping, receiving generic treatment not well-tailored to patient’s unique circumstances, and inconsistencies in continuity of service delivery and smooth transition to other services.

Conclusions
Patient feedback on service improvements are useful for service planners and policymakers to improve CHTT services. Based on the results of this study, the importance of staff timeliness, having a smooth transition during the end of care, and tailored staff training for various demographics can improve CHTT service quality and delivery. Further qualitative research is needed to gain a comprehensive understanding of patient needs and experiences in various regions and demographics.
Minimizing thermally induced residual stresses in metal additive manufacturing through peridynamics topology optimization
Authors: Khalilvandi Behrouzyar Sina , Kendibilir Abdullah , Cavus Omer Safa , Lahe Motlagh Peyman , Oren Soner , Orhangul Akin , Kefal Adnan , Koc Bahattin 
Published: February 2025

Abstract
Additive manufacturing (AM), characterized by layer-by-layer material addition using computer-aided design, presents an approach to manufacturing complex parts. However, AM processes naturally bring some difficulties such as thermally induced residual stresses, particularly in laser powder bed fusion (L-PBF) processes. This research paper proposes a novel topology optimization (TO) strategy that minimizes the residual stresses on the final product manufactured by metal AM process. In this context, peridynamics topology optimization (PD-TO) is utilized to perform TO within an integrated optimization framework, fed by thermal simulations of the L-PBF process. To calculate the residual stresses on classical TO results, we perform thermomechanical analyses based on the inherent strain method to model the manufacturing process. Afterward, those stress-concentrated regions are used to create virtual cracks for the subsequent PD-TO analysis. This approach allows us to embed potential cracks precisely in these high-stress regions, enhancing the efficacy of structural simulations. The methodology is interpreted through two comprehensive case studies: L-beam and Messerschmitt-Bölkow-Blohm (MBB) beam. The optimization process applied to both L-beam and MBB-Beam structures results in notable enhancements in their respective designs. For the L-beam, the optimization process, leads to a redistribution of material in the beam. This adjustment results in a decrease in residual stress by about

$$13\%$$

13
%

. For the MBB-Beam, optimization process induces geometric modifications that yield a stress distribution contributing to a reduction in residual stresses by about

$$15\%$$

15
%

for

$$r_{min}=2$$

r

min

=
2

, and

$$8\%$$

8
%

for

$$r_{min}=3$$

r

min

=
3

. Thus, in both structures, the optimization process effectively improves stress distribution.

Graphical Abstract
Wind turbine blade root and blade bearing fatigue damage estimation based on field data
Authors: Gebel Jakob , Rezaei Ashkan , Daems Pieter-Jan , Marini Rebeca , Matthys Jens-Jo , Nejad Amir R. , Helsen Jan 
Published: February 2025

Abstract
This study investigates the relationship between inflow properties of offshore wind turbines and fatigue damage accumulation in key machine components, specifically focusing on blade root and blade bearing fatigue. It showcases how LiDAR measurements can be used with a simulation model to provide fatigue damage estimations for a deployed turbine based on field data. By updating standardized wind field models with LiDAR measurements, the sensitivity of fatigue damage accumulation to variations in turbulence intensity and wind shear profiles is analyzed, and potential under- or over-predictions of fatigue damages are discussed. This approach offers valuable insights into more accurate lifetime predictions for turbine components and explores the possible benefits of LiDAR measurements and digital twin frameworks for fatigue damage estimation.
Demographics, clinical features and prognosis of patients with primary malignant conjunctival tumors at a tertiary hospital in Japan
Authors: Goto Hiroshi , Asakage Masaki , Niidime Erina , Yamakawa Naoyuki , Komatsu Hiroyuki , Tsubota Kinya , Umazume Kazuhiko , Usui Yoshihiko , Mori Hideki 
Published: February 2025

Abstract

Purpose
To clarify the demographic characteristics, clinical features and prognosis of patients with primary malignant conjunctival tumors diagnosed at a single tertiary hospital in Japan.

Study design
Retrospective, observational case series.

Methods
Patients with malignant conjunctival tumors diagnosed histopathologically at Tokyo Medical University Hospital between 2010 and 2022 were retrospectively reviewed. The demographic profile, clinical features and treatment outcomes were analyzed.

Results
A total of 359 patients with histopathologically proven malignant conjunctival tumors were included. All patients were Japanese. The most common malignant conjunctival tumor was lymphoma (n = 197, 54.9%), followed by squamous cell carcinoma (SCC) (n = 97, 27.0%), melanoma (n = 60, 16.7%), and others (n = 5, 1.4%). The mean age of patients at the time of diagnosis was 60.5 ± 17.4 years for lymphoma, 60.2 ± 15.8 years for SCC, and 65.8 ± 15.7 years for melanoma. Among 197 patients with lymphoma, 89.3% had extranodal marginal zone lymphoma (EMZL). Lymphomas were treated with external beam radiation therapy in 52.8%, surgical resection with or without cryopexy in 40.1%, and systemic chemotherapy in 4.0%. During an observation period of more than 12 months, recurrence was observed in 8.4% and extraocular lymphoma occurred in 1.7%. In SCC and melanoma, common surgical resection with sufficient safety margin, cryopexy, and application of 0.04% mitomycin C were performed as eye-preserving therapy. Orbital exenteration was performed in advanced cases. Recurrence rates and regional lymph node metastasis rates during an observation period of more than 12 months were, respectively, 30.1% and 6.2% in SCC. Recurrence rates and regional lymph node or distant organ metastasis rates during an observation period of more than 24 months for melanoma were 29% for both. Tumor-related mortality was 16% in melanoma, but 0% in lymphoma and SCC.

Conclusions
Lymphoma was the major malignant conjunctival tumor in a Japanese ophthalmology referral center, which may reflect a unique epidemiological trend in Japan compared to Western countries. The prognosis of lymphoma and SCC after appropriate treatment was favorable, except for some cases of advanced SCC.
Nrg4 Secreted by Brown Adipose Tissue Suppresses Ferroptosis of Sepsis-Induced Liver Injury
Authors: Feng Linqi , Cui Jun , Chen Wenlong , Zhu Lei , Li Panpan , Zhou Haitao , Sun Yang , Yi Wei 
Published: February 2025

Abstract
Sepsis is a leading cause of death, with the liver being particularly vulnerable to sepsis-related injuries. This damage significantly contributes to disease progression, underscoring the need for new treatments. Brown adipose tissue (BAT) secretes various cytokines, including neuregulin 4 (Nrg4), which plays a protective role in hepatic glucose and lipid metabolism. Ferroptosis, a key type of cell death in sepsis-induced liver injury, has recently gained attention. This study aimed to investigate how BAT-secreted cytokines alleviate liver ferroptosis in sepsis. Septic liver injury was induced in the control and BAT group using cecal ligation and puncture (CLP) and lipopolysaccharide injections. BAT removal worsened ferroptosis; in contrast, CL316243 activation reduced it. These findings suggest that Nrg4 secretion following BAT activation protects the liver during sepsis by inhibiting ferroptosis. Future therapies targeting BAT activation and Nrg4 could potentially mitigate sepsis-induced liver damage, offering new insights into treatment strategies.
Distribution of the Hessian values of Gaussian hypergeometric functions
Authors: Ono Ken , Pujahari Sudhir , Saad Hasan , Saikia Neelam 
Published: February 2025

Abstract
We consider a special family of Gaussian hypergeometric functions whose entries are cubic and trivial characters over finite fields. The special values of these functions are known to give the Frobenius traces of families of Hessian elliptic curves. Using the theory of harmonic Maass forms and mock modular forms, we prove that the limiting distribution of these values is semi-circular (i.e. SU(2)), confirming the usual Sato–Tate distribution in this setting.
Sex- and age-differences in supine positional obstructive sleep apnea in children and adults
Authors: Li Leping , Shi Min , Umbach David M. , Bricker Katelyn , Fan Zheng 
Published: February 2025

Abstract

Aim
To analyze sex differences in age trajectories of supine positional obstructive sleep apnea (POSA).

Methods
We conducted retrospective analysis of polysomnography studies from 13,144 individuals aged from 2 to 103 years with at least 30 min of both supine and lateral sleep. We used generalized linear mixed-effects models to estimate position-specific mean apnea-hypopnea index (AHI) values and logistic regression to estimate the proportion with POSA or with exclusive POSA among individuals with obstructive sleep apnea (OSA). Predictors included sex, 5-y age group, sleep position, and their interactions.

Results
Supine AHI was higher than lateral AHI regardless of age or sex except under age 5 y. The ratio of supine AHI to lateral AHI reliably exceeded 2 after age 30–35 in males and age 50–55 in females. For both sexes, the proportion with POSA among individuals with OSA increased rapidly with age until 30–35 and then stabilized. The proportion with POSA among individuals with OSA was significantly higher in males than females for each age group between 40 and 75 (p < 0.03). Among individuals with OSA in those 20 and older, the proportion with POSA was 64.6% (95% CI: 62.7%, 66.5%) in males and 55.8% (95% CI: 53.6%, 57.8%) in females. The proportion of individuals showing exclusive POSA also increased with age and peaked near 41% at age 15–20 in males and at age 20–25 in females.

Conclusion
POSA becomes more common with age in both sexes; in women, its prevalence is generally lower but continues to increase after age 65.
Development and implementation of an IVR-based assessment system for student teachers’ professional vision
Authors: Liu Tzu-Chien , Lin Yi-Chun 
Published: February 2025

Abstract
Professional vision (PV), which includes the ability to perceive and interpret classroom events, is important for classroom behaviour management, particularly in the training of student teachers. However, to date, few assessment systems that can assess student teachers’ professional vision by immersing them in a realistic classroom environment (presence) from their own perspective (first-person perspective) have been developed. To address this gap, this study employs a design-based research approach to develop an immersive virtual reality (IVR) technology-based professional vision assessment system (IVR-based PVAS). The research outlines the four-stage process through which the system was constructed to meet the requirements of professional vision assessment and address the core challenges of the current assessment approach. Twenty-four student teachers were enrolled as participants in an implementation case study in which their perceptions and interpretations of seven classroom events related to student misbehaviour were assessed via an IVR-based PVAS. The participants’ problems with perception and interpretation were diagnosed with multiple assessment indices. The benefits of the IVR-based PVAS are summarised, and recommendations are provided for the use of this assessment system in both instruction and research.
Framing Empathy: Examining Audience Responses to Female-On-Male Sexual Violence
Authors: Tselenti Danai , Cardoso Daniel , Carvalho Joana 
Published: February 2025

Abstract
The purpose of this secondary study was to investigate readers’ empathic framings in response to a female-on-male rape literary story, as articulated in online reviews on Goodreads. Drawing upon Nabi’s “emotions-as-frames” approach, we conducted a qualitative framing analysis by using a combination of deductive and inductive strategies. Two overarching empathy frames already present in the literature (bright, and dark empathy) served as interpretive anchors for categorizing empathic responses. Additionally, sentiment analysis was used to assess responses’ emotional valences. Qualitative findings yielded five main framings: (1) female-centered empathy and (2) sadistic empathy (aligning with the dark empathy frame); (3) empathic distress and (4) empathic anger (demonstrating overlaps between the bright and dark empathy frame), and (5) compassion (characteristic of the bright empathy frame). Sentiment analysis results showed a notable presence of mixed sentiments. Our findings highlight how empathy operates across a spectrum, encompassing various combinations of self-oriented and other-oriented framings with diverse emotional valences (positive, negative and mixed). These nuanced responses shape distinct paths of feeling through, with/as, for, or even showing concern for the fictional male victims. They further point to the significance of “feeling rules” that socially distribute empathy and establish hierarchies of “deserving” and “non-deserving” recipients. Departing from previous research that approaches empathic reactions to rape themes within a unidimensional perspective, our findings point to the importance of addressing the interrelations between audience responses and multi-dimensional, multivalent emotional flows. We further discuss the implications of the “darker” sides of empathic engagement for sexual violence prevention and efforts to challenge male rape myths.
Zanubrutinib in Japanese treatment-naive and relapsed/refractory patients with Waldenström macroglobulinemia and CLL/SLL
Authors: Izutsu Koji , Ishikawa Takayuki , Shimada Kazuyuki , Kubo Kohmei , Kondo Takeshi , Fujimoto Katsuya , Fujisaki Tomoaki , Kurahashi Shingo , Nagafuji Koji , Sakai Rika , Jo Tatsuro , Nakazato Tomonori , Sunami Kazutaka , Kasahara Senji , Cohen Aileen , Takai Motohisa , Zhong Jinhua , Takeuchi Masahiro 
Published: February 2025

Abstract
Zanubrutinib is a selective second-generation Bruton tyrosine kinase inhibitor approved in various B-cell malignancies globally. The phase 1/2 BGB-3111-111 study evaluated the efficacy and safety of zanubrutinib 160 mg twice daily orally in Japanese patients with treatment-naive or relapsed/refractory mature B-cell malignancies. Here, efficacy results from Part 2 in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; n = 19) and Waldenström macroglobulinemia (WM; n = 19), and safety results from Parts 1 (N = 6) and 2 (N = 49) are presented, with the first dose between 30 January, 2020, and 31 October, 2022. As of 10 May, 2023, investigator-assessed overall response rates were 100% (19/19) and 94.7% (18/19) in CLL/SLL and WM, respectively, with median follow-up of 27.9 and 26.8 months; 24-month progression-free survival rates were 71.4% and 100% in treatment-naive and relapsed/refractory CLL/SLL and 83.9% and 100% in treatment-naive and relapsed/refractory WM, respectively. In patients with B-cell malignancies, any-grade treatment-emergent adverse events (TEAEs) occurred in 53 (96.4%) and serious TEAEs in 18 (32.7%). Common TEAEs were platelet count decreased (18.2%), pyrexia (18.2%), COVID-19 (14.5%), and neutrophil count decreased (12.7%). With median follow-up > 2 years, zanubrutinib demonstrated durable efficacy in Japanese patients with CLL/SLL or WM and a favorable safety profile consistent with global phase 3 studies.
Assessment of fall armyworm tolerant maize hybrids for sustainable maize production in sub-Saharan Africa
Authors: Amegbor Isaac Kodzo , Adu Gloria Boakyewaa , Nelimor Charles , Prasanna Boddupalli M. , Beyene Yoseph , Chivasa Walter , Gethi James Gichuru , Togola Abou , Jamal-deen Abdulai , Adogoba Desmond Sunday , Nboyine Jerry , Kusi Francis , Ribeiro Priscilla Francisco , Keteku Agbesi Kwadzo , Wandaat Emmanuel , Darkwa Kwabena , Atosona Benedicta , Labuschagne Maryke 
Published: February 2025

Abstract
Fall armyworm (Spodoptera frugiperda (J.E. Smith)) has become a significant pest to maize production, causing huge yield losses in sub-Saharan Africa. This study evaluated three non-Bt maize hybrids with tolerance to fall armyworm (FAW) along with a commercial hybrid check for yield and agronomic performance under natural FAW infestation and chemical control conditions in both on-station and on-farm trials. Significant differences were observed among the hybrids with the FAW tolerant hybrids showing reduced leaf and ear damage compared to the commercial hybrid. These hybrids also exhibited high grain yield performance, outyielding the commercial check by 197–252%. Mean grain yield under FAW infestation ranged from 6009.88 to 7117.30 kg ha−1 without chemical control, and even higher (8441.24 kg ha−1) under limited chemical control. Stepwise multiple regression analyses identified ear aspect, husk cover and ear damage as key traits accounting for 98% of the total variation in grain yield under FAW infestation. Participatory variety selection showed high farmer preference for these hybrids. The availability of these hybrids to farmers promises to enhance food security, reduce the environmental impact of insecticides, alleviate cost burdens on farmers, and increase household income.
CALR—mutant myeloproliferative neoplasms: insights from next-generation sequencing
Authors: Mroczkowska-Bękarciak Aleksandra , Szeremet Agnieszka , Chyrko Olga , Wróbel Tomasz 
Published: February 2025

Abstract
Essential thrombocythemia and primary myelofibrosis belong to the group of BCR::ABL1-negative myeloproliferative neoplasms. The presence of mutations in the JAK2, CALR, and MPL genes is essential for the diagnosis of myeloproliferative neoplasms. These mutations are called “driver” mutations. However, not only leading mutations have been identified in patients with MPN, but also more than half of individuals with essential thrombocythemia and more than 80% of patients with myelofibrosis have additional mutations. One technique that makes it possible to find prognostic, predictive, and diagnostic indicators is next-generation sequencing. Coexisting mutations are associated with reduced response to therapy, shortened overall survival, and a higher risk of transformation to acute myeloid leukemia or myelofibrosis. The study group consisted of 42 patients with the diagnosis of BCR::ABL1-negative MPN and the presence of a mutation in the CALR gene. The research material was archival, and DNA was obtained from patients’ peripheral blood. Forty genes (17 genes, 23 hotspots) were sequenced using the commercial kit AmpliSeq for Illumina Myeloid Panel applying the targeted next-generation sequencing approach. For the study, the Illumina MiniSeq platform was used. The analysis of the obtained genetic results was carried out using bioinformatics tools and genetic databases. We studied 42 CALR-positive ET (n = 28) and MF (n = 14) patients with NGS panel testing. The median age at diagnosis of the entire patient series was 58 years. Additional mutations were detected in 48% of patients in the whole cohort. The most frequently mutated genes in the study population were ASXL1, TET2, and DNMT3A, which are largely associated with epigenetic regulatory mechanisms. NGS panel studies represent a breakthrough in the diagnostic and prognostic evaluation of MPNs with CALR mutations. The ability to perform such a comprehensive study provides valuable information on the biology of the disease and the selection of the appropriate treatment regimen. The use of new technologies shows that not only driver mutations have clinical significance for the patient. NGS has the potential to increase the precision and effectiveness of diagnosis and prognosis.