bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Explicit Convection on Climate Change in the West African Monsoon and Central West African Sahel Rainfall
Authors: Jackson Lawrence S. , Marsham John H. , Parker Douglas J. , Finney Declan L. , Fitzpatrick Rory G. J. , Rowell David P. , Stratton Rachel A. , Tucker Simon 
Published: December 2021

AbstractThe West African monsoon (WAM) is the dominant feature of West African climate providing the majority of annual rainfall. Projections of future rainfall over the West African Sahel are deeply uncertain, with a key reason likely to be moist convection, which is typically parameterized in global climate models. Here, we use a pan-African convection-permitting simulation (CP4), alongside a parameterized convection simulation (P25), to determine the key processes that underpin the effect of explicit convection on the climate change of the central West African Sahel (12°–17°N, 8°W–2°E). In current climate, CP4 affects WAM processes on multiple scales compared to P25. There are differences in the diurnal cycles of rainfall, moisture convergence, and atmospheric humidity. There are upscale impacts: the WAM penetrates farther north, there is greater humidity over the northern Sahel and the Saharan heat low regions, the subtropical subsidence rate over the Sahara is weaker, and ascent within the tropical rain belt is deeper. Under climate change, the WAM shifts northward and Hadley circulation weakens in P25 and CP4. The differences between P25 and CP4 persist, however, underpinned by process differences at the diurnal scale and large scale. Mean rainfall increases 17.1% in CP4 compared to 6.7% in P25 and there is greater weakening in tropical ascent and subtropical subsidence in CP4. These findings show the limitations of parameterized convection and demonstrate the value that explicit convection simulations can provide to climate modelers and climate policy decision makers.
Mental disorders and their impact on school performance and high school completion by gender in Australia: A matched population-based cohort study
Authors: Mitchell Rebecca J , McMaugh Anne , Schniering Carolyn , Cameron Cate M , Lystad Reidar P , Badgery-Parker Tim , Nielssen Olav 
Published: December 2021

Background: Young people with a mental disorder often perform poorly at school and can fail to complete high school. This study aims to compare scholastic performance and high school completion of young people hospitalised with a mental disorder compared to young people not hospitalised for a mental disorder health condition by gender. Method: A population-based matched case-comparison cohort study of young people aged ⩽18 years hospitalised for a mental disorder during 2005–2018 in New South Wales, Australia using linked birth, health, education and mortality records. The comparison cohort was matched on age, gender and residential postcode. Generalised linear mixed modelling examined risk of school performance below the national minimum standard and generalised linear regression examined risk of not completing high school for young people with a mental disorder compared to matched peers. Results: Young males with a mental disorder had over a 1.7 times higher risk of not achieving the national minimum standard for numeracy (adjusted relative risk: 1.71; 95% confidence interval: [1.35, 2.15]) and reading (adjusted relative risk: 1.99; 95% confidence interval: [1.80, 2.20]) compared to matched peers. Young females with a mental disorder had around 1.5 times higher risk of not achieving the national minimum standard for numeracy (adjusted relative risk: 1.50; 95% confidence interval: [1.14, 1.96]) compared to matched peers. Both young males and females with a disorder had around a three times higher risk of not completing high school compared to peers. Young males with multiple disorders had up to a sixfold increased risk and young females with multiple disorders had up to an eightfold increased risk of not completing high school compared to peers. Conclusion: Early recognition and support could improve school performance and educational outcomes for young people who were hospitalised with a mental disorder. This support should be provided in conjunction with access to mental health services and school involvement and assistance.
Key demographic and mental disorder diagnostic differences between Australian First Nations and non-First Nations clinic-referred children and adolescents assessed in a culturally appropriate and safe way
Authors: Vance Alasdair , Winther Jo , McGaw Janet , White Selena 
Published: December 2021

Objective: Increased point prevalence rates of oppositional defiant disorder and conduct disorder have been reported in American Indian and Canadian First Nations children and adolescents. To date, in Australia, there has been no published examination of standardized Diagnostic and Statistical Manual mental disorder diagnoses in First Nations children and adolescents, determined after addressing key cultural methodological issues. Methods: In all, 113 First Nations children and adolescents and 217 non-First Nations young people, aged 6–16  years, age, gender, mental disorder symptom severity, symptom-linked distress and impairment matched were recruited in a case control study. Also, 112 typically developing non-First Nations participants, age and gender matched to the other two clinical groups as a second comparison group were recruited. Diagnostic and Statistical Manual mental disorder diagnoses via semi-structured clinical interview, social adversity status and full scale IQ were determined in all participants with cultural validity and reliability of the impairing patterns of symptoms in First Nations young people determined by First Nations mental health staff and Aboriginal Health Liaison Officers. Full scale IQ and social adversity status were appropriately controlled in the Logistic Regression analyses of Diagnostic and Statistical Manual mental disorder diagnoses between the two clinical groups. Results: Oppositional defiant disorder was the only diagnostic and statistical manual mental disorder diagnosis that differed between the First Nations and non-First Nations clinical groups, adjusting for confounding by social adversity status and full scale IQ in the multivariable model. The point prevalence of oppositional defiant disorder was 2.94 times higher (95% confidence interval: 1.14–7.69) among the First Nations compared to the non-First Nations clinical group. Conclusion: Key known risk factors for oppositional defiant disorder can be identified early and holistically managed in First Nations young people. This will prevent oppositional defiant disorder decreasing their access to mental health services and increasing their involvement in the criminal justice system. In addition, the resilience building aspects of oppositional defiant disorder that may enhance self-respect need to be nurtured.
Headache provocation by nitric oxide in men who have never experienced a headache
Authors: Olofsson Isa Amalie , Falkenberg Katrine , Olesen Jes , Hansen Thomas Folkmann 
Published: December 2021

Introduction In the general population 4% have never experienced a headache. Freedom from headache could be due to distinctive protective mechanisms or a lack of environmental risk factors for headache. Isosorbide-5-mononitrate is an organic nitrate which in the body is metabolised to nitric oxide. The nitric oxide pathway plays a crucial role in the primary headaches. We hypothesized that people who are free from headache are protected by distinctive mechanisms in the nitric oxide pathway. Methods We performed an observer blinded case-control study using nitric oxide to provoke a headache. 32 headache free male participants and 26 randomly selected male controls received 60 mg Isosorbide-5-mononitrate orally on the study day. Participants fill out a headache diary with headache intensity and characteristics until 12 hours after administration of Isosorbide-5-mononitrate. Primary endpoint were areas under the curve of headache intensity score. Results All 58 participants completed the study. There was no significant difference in headache incidence, headache intensity score or migraine-like attack between headache free participants and controls. Conclusion We show that men who have never experienced a headache develop a headache when provoked with Isosorbide-5-mononitrate. This indicates that freedom from headache in men is not related to the nitric oxide pathway which is involved in the primary headache disorders.
Management of complex ischial-urethral fistula in neurogenic patients performing clean intermittent self-catheterization
Authors: Ammirati Enrico , Geretto Paolo , Giammò Alessandro , Falcone Marco , Gontero Paolo , Manassero Alberto 
Published: December 2021

Introduction: Neurogenic patients performing clean-intermittent self-catheterization (CIC) may develop an urethral erosion, resulting in ischial-urethral fistulas (I-UF). In this work we present our single-center experience in dealing with this peculiar complication. Methods: In this work we included all neurogenic patients performing CIC treated at out Institution for I-UF. All patients had a spinal cord injury or myelomeningocele. We extracted from the patients’ medical records the surgical management and postoperative clinical data. We defined failure the persistence of the fistula at X-ray contrast fistulography, retrograde urethrography, or uretrocystoscopy. Results: We treated 11 patients (8 spinal cord injury, 3 myelomeningocele). Four patients have been treated with the placement of a new generation urethral stent (Uventa) after surgical toilette of the skin ulcer and placement of a temporary suprapubic catheter. All patients demonstrated a complete healing of the urethral lesion at stent removal and continued CIC without any difficulty. Four patients have been treated with perineal urethroplasty, requiring a buccal mucosal graft in two cases. In two patients a suprapubic permanent catheter was placed for a simpler bladder management due to the patients’ comorbidities. In one case the incidental finding of an high grade muscle invasive urothelial bladder cancer, made it mandatory to perform an uretheroileocutaneostomy. Conclusions: This work represent a unique series of I-UF in neurogenic patients performing CIC. Surgical urethral reconstruction, often with the use of buccal mucosa in large lesions, may be a difficult solution in neurogenic patients, new generation stents (Uventa) represent a minimally invasive, effective, and safe alternative.
Experimental research on the muzzle response characteristics of small unmanned ground vehicles with small arms
Authors: Ding Yugang , Zhou Kedong , He Lei , Yang Haomin 
Published: December 2021

The muzzle response is the main feature affecting the firing accuracy of weapons. To research the muzzle response characteristics of small unmanned ground vehicles with small arms (SUGVsSA) during shooting, this paper designs a test method that combines an inertial measurement system (IMS) with a high-speed photogrammetric system (HSPS) to measure the muzzle response. That is, an inertial measurement unit (IMU) is fixed onto the gun body to record the three-dimensional angular motion of the barrel; meanwhile, a high-speed camera is used to capture the characteristic markers of the unmanned ground vehicle from the side. After data processing, the muzzle response curves during four consecutive firings when the vehicle is running at different speeds and firing angles are obtained. Considering the presence of noise in muzzle response signals, the wavelet threshold de-noising (WTD) algorithm based on a novel variable threshold function is used to de-noise the test signal. The processing results demonstrate that the WTD algorithm based on the novel variable threshold function can not only suppress noise in the muzzle response signal but also retain the local details of the signal. The combination of the IMS and HSPS complements the muzzle response data and can comprehensively and accurately reflect the muzzle response characteristics of SUGVsSA. As the vehicle speed and firing angle increase, the muzzle vibration intensifies, only when the vehicle speed is 0.3 m/s, and the muzzle maximum elevation angle displacement after each firing decreases when it is stationary. The results presented in this paper may provide a workable reference for understanding the muzzle response characteristics of SUGVsSA and evaluating the firearm compatibility of other unmanned systems.
Plasma levels of sirtuin and adiponectin in patients with primary open-angle glaucoma, exfoliative glaucoma, and healthy controls
Authors: Yucel Gencoglu Aysun , Irkec Murat , Kocabeyoglu Sibel , Dikmen Z. Gunnur , Karakaya Jale , Konstas Anastasios G.P. 
Published: December 2021

Purpose To compare plasma levels of sirtuin 1 (SIRT1) and adiponectin (APN) in patients with primary open-angle glaucoma (POAG), exfoliative glaucoma (XFG), and healthy control subjects. Methods This prospective case-control study collected plasma samples from 118 participants. All subjects underwent a comprehensive ophthalmologic examination before the acquisition of a plasma sample. Plasma samples were obtained from 40 POAG, 38 XFG, and 40 healthy control subjects without any evidence of systemic or ocular disease. Serum SIRT1 and APN levels were estimated by an enzyme-linked immunosorbent assay, ELISA (Elabscience, Houston, USA) method. Statistical analysis of results relied on Kolmogorov-Smirnov, Kruskal-Wallis, Chi-square, analysis of variance (ANOVA) tests, and linear regression analysis, where appropriate. Results A significant decrease in SIRT1 levels was observed in POAG patients compared to healthy controls (p = 0.004, Dunn's test). In contrast, no difference was detected between XFG and POAG patients or healthy controls (p = 0.32 and p = 0.34, respectively, Dunn's test). There was no significant difference in plasma APN levels between the three groups under investigation (p = 0.59, ANOVA). Conclusion Alterations in serum level of SIRT1 may suggest a possible role in POAG via potential effects in neuroprotection and oxidative stress.
Family violence homicide rates: a state-wide comparison of three data sources in Victoria, Australia
Authors: Sarkar Reena , Dipnall Joanna F , Bassed Richard , Ozanne-Smith AO Joan 
Published: December 2021

Background Family violence homicide (FVH) is a major public health and social problem in Australia. FVH trend rates are key outcomes that determine the effectiveness of current management practices and policy directions. Data source–related methodological problems affect FVH research and policy and the reliable measurement of homicide trends. Objective This study aimed to determine data reliability and temporal trends of Victorian FVH rates and sex and relationship patterns. Method FVH rates per 100,000 persons in Victoria were compared between the National Coronial Information System (NCIS), Coroners Court of Victoria (CCoV) Homicide Register, and the National Homicide Monitoring Program (NHMP). Trends for 2001–2017 were analysed using Joinpoint regression. Crude rates were determined by sex and relationship categories using annual frequencies and Australian Bureau of Statistics population estimates. Results NCIS closed FVH cases totalled 360, and an apparent downward trend in the FVH rate was identified. However, CCoV and NHMP rates trended upwards. While NCIS and CCoV were case-based, NHMP was incident-based, contributing to rate variations. The NCIS-derived trend was particularly impacted by unavailable case data, potential coding errors and entry backlog. Neither CCoV nor NHMP provided victim-age in their public domain data to enable age-adjusted rate comparison. Conclusion Current datasets have limitations for FVH trend determination; most notably lag times for NCIS data. Implications This study identified an indicative upward trend in FVH rates in Victoria, suggesting insufficiency of current management and policy settings for its prevention and control.
EMG Activity With Use of a Hands-Free Single Crutch vs a Knee Scooter
Authors: Dewar Cuyler , Grindstaff Terry L. , Farmer Brooke , Sainsbury Morgan , Gay Sam , Kroes Weston , Martin Kevin D. 
Published: December 2021

Background: Foot and ankle injuries frequently require a period of nonweightbearing, resulting in muscle atrophy. Our previous study compared a hands-free single crutch (HFSC) to standard axillary crutches and found increased muscle recruitment and intensity while using the HFSC. Knee scooters are another commonly prescribed nonweightbearing device. The purpose of this study is to examine the electromyographic (EMG) differences between an HFSC and knee scooter, in conjunction with device preference and perceived exertion. Methods: A randomized crossover study was performed using 30 noninjured young adults. Wireless surface EMG electrodes were placed on the belly of the rectus femoris (RF), vastus lateralis (VL), lateral gastrocnemius (LG), and gluteus maximus (GM). Participants then ambulated along a 20-m walking area while 15 seconds of the gait cycle was recorded across 3 conditions: walking with a knee scooter, an HFSC, and with no assistive device. Mean muscle activity and peak EMG activity were recorded for each ambulatory modality. Immediately following testing, patient exertion and device preference was recorded. Results: The RF, LG, and GM showed increased peak EMG activity percentage, and the LG showed increased mean muscle activity while using the HFSC compared with the knee scooter. When comparing the knee scooter and HFSC to walking, both showed increased muscle activity in the RF, VL, and LG but no difference in the GM. There was no statistical difference in participant preference, whereas the HFSC had a statistically significant higher perceived exertion than the knee scooter ( P < .001). Conclusion: In this group of young, healthy noninjured volunteers, the HFSC demonstrated increased peak EMG activity in most muscle groups tested compared with the knee scooter. Level of Evidence: Level II, prospective comparative study.
Aberrant expression of CD54 detected by flow cytometry is a characteristic of B-lymphoma cells in bone marrow specimens
Authors: Wang Wei , Li Yan , Ali Haval , Zhao Linjun , Mei Di , Hu Wenqing , Jiang Bin 
Published: December 2021

AbstractBackgroundFlow cytometry (FC) is a popular method to detect bone marrow (BM) involvement in patients with B-cell non-Hodgkin lymphoma (B-NHL). The majority of screen panels of FC still rely on finding monoclonal B-cells, e.g., B-cells with immunoglobin (Ig) light-chain restriction, which has many limitations. Therefore, exploring new markers is warranted.MethodsA total of 52 cases of B-NHL with BM involvement were collected. The median age was 60 years. Out of these 52 cases, 34 were male, and 18 were female. A 10-color FC panel was used to detect the expression of CD54 on lymphoma cells. The expression of CD54 was calculated as the mean fluorescence index ratio (MFIR) and was described as the mean ± standard error of the mean (SEM).ResultsUp to 18/52 (34.62%) of BM specimens abnormally expressed an increased level of CD54, including 1/10 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), 9/13 cases of mantle cell lymphoma (MCL), 2/14 cases of follicular lymphoma (FL), 5/9 cases of marginal zone lymphoma (MZL), and 1/3 cases of high-grade B-NHL (HG B-NHL). The expression level of CD54 was significantly increased in MCL cases (53.41 ± 11.04) compared with CLL/SLL cases (11.66 ± 2.79) and FL cases (13.49 ± 2.81). The lowest percentage of CD54-positive B-cells attained 0.13%. In 5/9 cases of MZL and 1/3 cases of HG B-NHL, increased expression of CD54 was the only abnormal immunophenotype detected besides Ig light-chain restriction. No aberrant CD54 expression was identified by FC in lymphoplasmacytic lymphoma (LPL) (0/2) and Burkitt lymphoma (BL) (0/1) cases. Aberrant expression of CD54 was not related to plasma cell differentiation.ConclusionLymphoma cells, especially in MCL and MZL cases, frequently show increased expression of CD54. Such aberrant expression is not related to plasma cell differentiation. We highly recommend adding CD54 to the FC screening panel to detect BM involvement in patients with B-NHL.
Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
Authors: Qi Yi , Wei Yaxue , Yu Fengyan , Lin Qianxing , Yin Jingwen , Fu Jiawu , Xiong Susu , Lv Dong , Dai Zhun , Peng Qian , Wang Ying , Zhang Dandan , Wang Lulu , Ye Xiaoqing , Lin Zhixiong , Lin Juda , Ma Guoda , Li Keshen , Luo Xudong 
Published: December 2021

Abstract
Background
Schizophrenia is currently considered to be a polygene-related disease with unknown etiology. This research will verify whether the single nucleotide polymorphism (SNP) of the long intergenic noncoding RNA01080 (linc01080) contributes to the susceptibility and phenotypic heterogeneity of schizophrenia, with a view to providing data support for the prevention and individualized treatment of this disease.

Method
The SNP rs7990916 in linc01080 were genotyped in 1139 schizophrenic and 1039 controls in a Southern Chinese Han population by the improved multiplex ligation detection reaction (imLDR) technique. Meanwhile, we assessed and analyzed the association between this SNP and schizophrenics’ clinical symptoms, and the cognitive function.

Result
There was no significant difference in genotype distribution, allele frequency distribution, gender stratification analysis between the two groups. However, the SNP of rs7990916 was significantly associated with the age of onset in patients with schizophrenia (P = 8.22E-07), patients with T allele had earlier onset age compared with CC genotype carriers. In terms of cognitive function, patients with T allele scored lower than CC genotype carriers in the Tower of London score and symbol coding score in the Brief assessment of Cognition (BACS), and the difference was statistically significant (P = 0.014, P = 0.022, respectively).

Conclusion
Our data show for the first time that linc01080 polymorphism may affect the age of onset and neurocognitive function in patients with schizophrenia.