bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nilai Kearifan Lokal Bugis sebagai Sumber Belajar Sejarah Lokal pada Masyarakat Bugis di Kabupaten Bone
Authors: Khaeruddin  , Umasih U , Ibrahim Nurzengky 
Published: March 2021

Abstrak:Identitas kelokalan yang berupa sastra dan sejarah Bugis Bone yang menjadi kekayaan intelektual bagi masyarakat Bone yang sangat relevan untuk dijadikan sebagai sumber belajar sejarah lokal. Penelitian ini bertujuan untuk mengetahui pemahaman konsepsi kearifan lokal Bugis dalam kehidupan masyarakat kabupaten Bone dan mengetahui penerapan nilai-nilai kearifan lokal pada masyarakat Bugis melalui Sekolah Bugis. Metode penelitian yang digunakan merupakan penelitian kualitatif dengan metode pengumpulan data dilakukan dengan cara observasi, wawancara, studi pustaka. Hasil penelitian menunjukkan bahwa nilai kearifan lokal Bugis yang berupa sastra dan sejarah yang didalamnya mengandung pappaseng (pesan-pesan leluhur) yang mencakup ada’ tongeng (berkata benar), lempu (jujur), getteng (teguh pendirian), sipakatau (saling menghormati), sipakalebbi (saling memuliakan), assitinajang (kepatutan) dan mappesonae ri Dewata Seuwwae (berserah diri kepada Tuhan) dijadikan sebagai sumber belajar sejarah lokal. Nilai-nilai kearifan lokal tersebut dipahami sebagai milik bersama masyarakat Bone dan dipelajari bersama melalui sekolah Bugis sebagai pedoman dalam sikap dan bertindak. Begitupun juga dengan peristiwa-peristiwa sejarah yang terjadi dimasyarakat Bone mengandung pappaseng baik secara tersirat dan tersurat yang kemudian ditelaah dan dijadikan sumber belajar sejarah lokal.
Identifying Risk Factors and Spatial Clustering of HIV Infection Among Female Sex Workers in India
Authors: Arumugam Elangovan , Joshua Vasna , Aridoss Santhakumar , Balasubramanian Ganesh , Jaganathasamy Nagaraj , David Joseph K , Mathiyazhakan Malathi , Natesan Manikandan , VM Padmapriya , Kumar Pradeep 
Published: March 2021

Background: The human immunodeficiency virus (HIV) epidemic in India is generally considered to be more concentrated, with the focus on high-risk groups including female sex workers (FSWs). The Integrated Biological and Behavioral Surveillance (IBBS), the first nationwide surveillance conducted during 2014-2015, collected many key indicators, including indicators related to HIV/STI transmission. The purpose of this study was to develop an index score for each domain surveyed and to identify focus areas for interventions among FSWs.
Methods: The study population consisted of 27,007 FSWs. Forty high-risk related covariates of HIV/STI transmission, demographic characteristics, sexual history, condom practices, knowledge of HIV/STI and biological variables were considered. The original data set was examined using the correlation matrix and was reduced to 15 highly-correlated factors using principal component analysis. The factors were further improved using varimax rotation and the percentage of variation was used as weights to obtain the initial score for each domain, which were then standardized for comparison. Bartlett’s test of sphericity was examined before the factor extraction.
Results: Six factors were extracted, which together explained about 73% of the total variation. The factors were: (1) more number of clients; (2) younger FSW and started selling sex at younger age; (3) experiencing condom breakage; (4) having occasional clients and poor HIV/AIDS knowledge; (5) illiteracy; and (6) a longer period of sex work. Six domains with an index score of above 80, from the states of Maharashtra, Rajasthan, Arunachal Pradesh, Uttar Pradesh, and Jharkhand need greater intervention.
Conclusion and Implications for Translation: FSWs’ current age, age at commencement of sex work, and the number of clients were the indicators most-associated with HIV infection. Therefore, program and policy interventions should focus on FSWs who are younger than <25 years, who started selling sex at <22 years, and who have >10 clients.
Key words: • Female Sex Worker • Kriged Map • Factor Analysis • Principle Component Analysis • HIV • Sexually Transmitted Infections

Copyright © 2021 Elangovan et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Culture of Primary Human Tracheobronchial Epithelial Cells
Authors: Dailey Lisa , McCullough Shaun D. 
Published: March 2021

Abstract
This protocol is intended for culture of primary human tracheobronchial epithelial cells (pHBEC) obtained by brush biopsy during clinical bronchoscopy, or purchased commercially, using Lonza-based medium.Note: This is a historical protocol. At the time of publication, this protocol has been superseded by a different version in the McCullough lab; however, it is being published to support the transparency and reproducibility of other studies by which it is referenced.Disclaimer: The information presented here has been reviewed and approved for publication by the US Environmental Protection Agency do not necessarily represent Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendations for use.
Candidate HPV-Specific T-Cells Expand in the Tumor Microenvironment During Chemoradiotherapy
Authors: Colbert Lauren , Alam Molly El , Lynn Erica , Edwards Julianna , Karpinets Tatiana , Wu Xiaogang , Chapman Bhavana , Sims Travis , Lin Daniel , Kouzy Ramez , Biegert Greyson , Medrano Andrea Delgado , Olvera Adilene , Sastry K. , Eifel Patricia , Jhingran Anuja , Lin Lilie , Ramondetta Lois , Futreal Andrew , Jazaeri Amir , Schmeler Kathleen , Yue Jingyan , Mitra Aparna , Yoshida-Court Kyoko , Wargo Jennifer , Solley Travis , Hegde Venkatesh , Nookala Sita , Yanamandra Ananta , Dorta-Estremera Stephanie , Mathew Geena , Kavukuntla Rohit , Papso Cassidy , Ahmed-Kaddar Mustapha , Kim Minsoo , Zhang Jianhua , Reuben Alexandre , Holliday Emma , Minsky Bruce , Koong Albert , Koay Eugene , Das Prajnan , Taniguchi Cullen , Klopp Ann 
Published: March 2021

Abstract
Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumor-specific antigens. It is not known whether immunity to E6 and E7 evolves during chemoradiotherapy (CRT) or affects survival. We used functional T-cell assays to identify candidate HPV-specific T-cells and T- cell motifs common across 86 patients with HPV-related cancers. These HPV-specific clones and E7-related motifs expanded over the course of treatment, whereas non-HPV-specific T-cells did not. In HPV16+ patients, improved recurrence-free survival was associated with this HPV-responsive T-cell expansion during CRT.
Characterization of The Expression of The Heavy Chain of 4F2 Antigen As a Therapeutic Target in Prostate Cancer
Authors: Maimaiti Maihulan , Sakamoto Shinichi , Sugiura Masahiro , Xu Minhui , Ando Keisuke , Saito Shinpei , Wakai Ken , Imamura Yusuke , Kanai Yoshikatsu , Kaneda Atsushi , Ikehara Yuzuru , Anzai Naohiko , Ichikawa Tomohiko 
Published: March 2021

Abstract
The 4F2 cell-surface antigen heavy chain (4F2hc) forms a heterodimeric complex with L-type amino acid transporter 1 (LAT1) and transports large neutral essential amino acids. However, in contrast to the traditional role of LAT1 in various cancers, the role of 4F2hc has largely remained unknown. The role of 4F2hc in prostate cancer was studied. Treatment of C4-2 cells with si4F2hc was found suppress cellular growth and migratory and invasive abilities, with this effect occurring through the cell cycle, with a significant decrease in S phase and a significant increase in G0/G1 phase, suggesting cell cycle arrest. In addition, it was proven by RNA seq that the key to 4F2hc’s impact on cancer is SKP2. The expression of 4F2hc and LAT1 in prostate cancer cells suggests the importance of 4F2hc. Furthermore, si4F2hc, through the downstream target SKP2, upregulates the protein expression of cyclin-dependent kinase inhibitors (P21cip1, P27kip1). Multivariate analysis showed that high 4F2hc expression was an independent prognostic factor for progression-free survival (HR 11.54, p=0.0357). High 4F2hc was related to the clinical tumour stage (p=0.0255) and Gleason score (p=0.0035). Collectively, 4F2hc contributed significantly to prostate cancer (PC) progression. 4F2hc may be a novel marker and therapeutic target in PC.
To Determine Prevalence of Otorhinolaryngological Symptoms in COVID-19 Positive Patients.
Authors: Savtale Saee , Hippargekar Prashant , Bhise Sudhir , Kothule Shankar 
Published: March 2021

Abstract
Objective- To determine prevelance of ENT symptoms in COVID 19 positive patients.Methods- A cross sectional study was performed at SRTR GMC AMBAJOGAI, a tertiary care hospital amongst the patients admitted in COVID 19 isolation ward with a positive RT- PCR report. Results- Amongst the included 180 patients, 112 patients had one or more ENT related symptoms that included throat pain (47.2%), loss of smell (55.5%), loss of taste (58.8%) and hearing loss (54.44%) along with generalizedCOVID 19 symptoms. Conclusion- ENT symptoms can be considered as biomarkers for early diagnosis of Covid-19 patients ensuring faster treatment and isolation allowing better containment of the disease.
Organizational Knowledge Translation Strategies for Allied Health Professionals in Traumatology Settings: A Realist Review Protocol
Authors: Latulippe Karine , Leblanc Annie , Gagnon Marie-Pierre , Boivin Katia , Lavoie Pascale , Dufour Joëlle , Lamontagne Marie-Ève 
Published: March 2021

Abstract
Background: Knowledge translation (KT) is an important means of improving health service quality. Most research on the effectiveness of KT strategies has focused on individual strategies, i.e., those targeting directly the modification of allied health professionals’ knowledge, attitudes, and behaviours, for example. In general, these strategies are moderately effective in changing practices (maximum 10% change). Effecting change in organizational contexts (e.g., change readiness, general and specific organizational capacity, organizational routines) is part of a promising new avenue to service quality improvement through the implementation of evidence-based practices.Methods: A realist review will be conducted to explore the various organizational KT strategy action mechanisms (how, why, for whom, to what extent and under what circumstances) with a view to facilitating the choice of effective strategies for sustainable implementation of evidence-based practice for allied health professionals in traumatology settings. The review will begin by presenting initial theories developed by the research team, followed by the search for evidence, the selection of literature on context-mechanism-outcome configurations related to organizational KT strategies, and end with a refinement of initial theories and a synthesis.Discussion: Using a systematic and rigorous method, this review will help guide decision makers and researchers in choosing the best organizational strategies to optimize the implementation of evidence-based practices.Registration: This protocol has been submitted for registration on the PROSPERO database on October 30, 2020 (ID: 216105).
Thymol-based Chitosan Nanogels Have Strong Antibacterial and Anti-biofilm Effects on Multidrug-resistant Pathogens
Authors: Gharaghie Tohid Piri , Beiranvand Sheida , Shirin Neda Jegargoshe , Elahianfar Yalda , Ghahari Somayeh , Ghahari Sajjad 
Published: March 2021

Abstract
In the present study, the antibacterial and antibiofilm effects of Thymol-based chitosan nanogels were investigated. After clinical screening of MDR strains from the hospital environment, the morphological characteristics of the synthesized nanoparticles were identified using SEM, DLS, XRD and FTIR and the efficiency of encapsulation, stability and drug release were evaluated. The expression of OmpA and PgaB biofilm genes were determined by q-Real-Time PCR and the antibacterial and cytotoxic properties of the nanoparticles were determined by well diffusion and MTT methods, respectively. Nanoparticles with a size of 82.71 nm, encapsulation efficiency of 76.54% and stability up to 60 days at 4 °C were prepared. The results of the biological study showed strong antibacterial properties of Thymol-based chitosan nanoparticles by reducing the expression of OmpA and PgaB biofilm genes at a significant level of P ≤ 0.05 and reducing antibiotic resistance compared to the free drug thymol and chitosan nanogels. Thymol-based chitosan nanogels at concentrations of 0.125 to 256μg/mL showed the lowest cytotoxicity against HEK-293 compared to chitosan and free Thymol nanogels. The results showed very strong antibacterial properties of Thymol-based chitosan nanogels against MDR strains such as Staphylococcus, Acinetobacter and Pseudomonas as the challenging bacteria of the century.
Bioinformatics analysis of RNA-seq data revealed critical genes in type 1 diabetes and molecular docking studies
Authors: G Prashanth , Vastrad Basavaraj , Tengli Anandkumar , Vastrad Chanabasayya , Kotturshetti Iranna 
Published: March 2021

Abstract
Background: Type 1 diabetes (T1D) is a serious threat to childhood life and has fairly complicated pathogenesis. Profound attempts have been made to enlighten the pathogenesis, but the molecular mechanisms of T1D are still not well known.Methods: To identify the candidate genes in the progression of T1D, Expression profiling by high throughput sequencing dataset GSE123658 was downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified, and gene ontology (GO) and pathway enrichment analyses were performed. The protein-protein interaction network (PPI), modules, target gene - miRNA regulatory network and target gene - TF regulatory network analysis were constructed and analyzed using HIPPIE, miRNet, NetworkAnalyst and Cytoscape. Finally, validation of hub genes was conducted by using ROC (Receiver operating characteristic) curve and RT-PCR analysis. Molecular docking studies were performed.Results: A total of 284 DEGs were identified, consisting of 142 up regulated genes and 142 down regulated genes. The gene ontology (GO) and pathways of the DEGs include cell-cell signaling, vesicle fusion, plasma membrane, signaling receptor activity, lipid binding, signaling by GPCR and innate immune system. Four hub genes were identified and biological process analysis revealed that these genes were mainly enriched in cell-cell signaling, cytokine signaling in immune system, signaling by GPCR and innate immune system. ROC curve and RT-PCR analysis showed that EGFR, GRIN2B, POLR2A and PRKACA might be involved in the advancement of T1D. Molecular docking studies showed high docking score.Conclusions: DEGs and hub genes identified in the present investigation help us understand the molecular mechanisms underlying the advancement of T1D, and provide candidate targets for diagnosis and treatment of T1D.
Numerical experiment research on failure characteristics of anchored rock with negative Poisson’s ratio bolt
Authors: chen feng , Du Yanhong , he manchao , sun xiaoming , ma tianhui 
Published: March 2021

Abstract
With the continuous increase of mining depth and engineering burying depth, the nonlinear physical and mechanical phenomena exhibited by rock are also more complicated. The load value often exceeds the yield strength of the traditional Poisson's ratio supporting materials, causing the supporting body to fail. Therefore, the bolt still needs to further in-depth research on new materials. In this paper, the rock model with a negative Poisson’s ratio bolt had been established, the material properties of negative Poisson’s ratio and the working principle of RFPA software were introduced, and RFPA software was used to study the reinforcement effect of negative Poisson's ratio bolt on the rock. The numerical experiment results show that, compared with the positive Poisson's ratio bolt, the negative Poisson's ratio bolt can significantly increase the bearing capacity of anchored rock, enhance the friction between the bolt body and the surrounding rock, and limit the rock movement. The anchored rock with negative Poisson’s ratio bolt can absorb more energy. Negative Poisson's ratio material is one of the future development directions of bolt material.
Nanoemulsion of Virgin Rapeseed and Sesame Oil improve Oxidation Stability and Sensoric acceptability of Vacuum Packed Fish Fillets
Authors: Anwer Iqra , Abbas Farzana , Hafeez-ur-Rehman Muhammad , Nadeem Muhammad , Khalil Maryyum , Butt Mahrukh , Inayat Muhammad 
Published: March 2021

Abstract
Background: Fish contains high polyunsaturated fatty acids and has good healthy biological values, so it is considered a vital ingredient in the human diet. Antioxidants play an essential role in the food industry due to their help breaking down the oxidation process. The consumer demands fresh refrigerated foods that extend shelf life without changing taste. By using oil and vacuum packaging techniques, considerable research has been conducted to preserve and extend the shelf life of Channa marulius fillets. Since rapeseed oil and sesame oil are considered good sources of antioxidants, their role in preserving and extending the shelf life of Channa marulius fillets is limited.Methods: Channa marulius fish fillets weighing 4-5 kg each were obtained from the market. The fillets were washed and divided into 5 groups using different concentrations of sesame oil (S.O) and rapeseed oil (R.O) nanoemulsion i.e., Control (C) without treatment, T1 (S.O 20%), T2 (S.O 25%), T3 (R.O 20%) and T4 (R.O 25%). The fillets were soaked in nanoemulsion for 30 minutes and packed with a vacuum packing machine before storing at -40 oC. After an interval of 0, 4, 7, and 15 days the oxidative stability, antioxidant activity and sensory evaluation determined of each treatment were determined. Result: Compared with the control group, the free fatty acid (FFA) levels and peroxide values (PV) values were lower in the treated groups. Lipid oxidation increased over time in the control group due to lipid oxidation. Total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of the fillets decreased due to the nanoemulsion. Oxidative stability fluctuated and increased with storage time because of more fatty acid hydrolysis. The reduction was noted in the antioxidant property because it hampered the oxidation stability. Channa marulius' sensory evaluation revealed that nanoemulsion and vacuum packaging had a higher sensory score than the control group. Conclusion: The role of rapeseed and sesame oil as natural antioxidants was investigated to preserve and extend the shelf life of Channa marulius fillets. The use of nanoemulsions by using sesame oil and rapeseed oil reduced the oxidation stability and enhance the antioxidant activity of Channa marulius fillets. Among the oils, it can be concluded that sesame oil can be recommended for nanoemulsion as a good preservative for fish fillets.
Preterm Severe Neonatal Morbidity and Mortality in Breech Presentation Regarding the Onset Mode of Labor
Authors: Guerini Claire , Diane Korb , Olivier Sibony 
Published: March 2021

Abstract
PurposeThe objective was to assess neonatal severe morbidity in case of cervical ripening, in premature breech fetuses, comparatively at spontaneous labor. MethodsThis is a retrospective study conducted in a tertiary center.Women with alive singleton breech between 28 and 36+6 weeks of gestation were considered. We compared women with an unfavorable cervix, who had an indication to deliver, to women in spontaneous labor.The primary outcome was a composite morbi-mortality criterion including perinatal death, traumatic event, 5-min Apgar < 4, moderate / severe encephalopathy, seizures, Intra Ventricular Hemorrhage grade 3-4, necrotizing enterocolitis grade 2-3. The association between the onset of labor and severe neonatal morbidity was assessed by logistic regression model. A propensity score approach with inverse probability of treatment weighting was performed to control indication bias. ResultsWe included 212 patients: 64 in the induced labor group and 136 in the spontaneous labor group. Labor was induced mostly for fetal growth restriction (34.4%), oligoamnios (18.7%) and pre-eclampsia (18.7%). When induced labor, 45.3% of patients delivered vaginally, and 86% when spontaneous labor.The rate of neonatal morbidity was similar in two groups (4.7% versus 5.2%, p=0.889). There was no association between the onset of labor and severe neonatal morbidity (OR 0.99, 95% CI 0.2-3.6)). After applying propensity scores, induction of labor was not associated with improved severe neonatal morbidity (OR 0.9, 95% IC 0.4-2.5).ConclusionThe onset mode of labor do not seem to have an effect on severe neonatal morbidity and mortality in preterm breech fetuses.
A study on the attenuation of ATO cardiotoxicity by SOG though Nrf2/ARE pathway
Authors: Wang Yang , Shen Jianying , Yang Miyi , Sui Feng , Li Xiaoqiang , Tan Yuqing 
Published: March 2021

Abstract
Arsenic trioxide (ATO, Trisenox) is an ancient Chinese medicine which have good clinical effects for acute promyelocytic leukemia (APL). However, ATO has serious cardiotoxicity which has restricted its widely applied in clinic. Saposhnikovia divaricata (Trucz.) Schischk was an antidote to ATO in Chinese medical book. Sec-O-Glucosylhamaudol (SOG) is one of its four main active ingredients. So we explore if SOG can detoxify the ATO’s cardiotoxicity through the Nuclear factor erythroid 2-related factor 2(Nrf2) signal pathway and apoptosis pathway. We added 10 μM ATO and 10, 50, 100 μM SOG in Rat cardiac myocyte-like H9c2 cells. The results indicate SOG can active Nrf2 signal pathway, improve Nrf2 phosphorylation levels, promote the expression of Nrf2, HO-1, NQO1 gene and protein, increase the contents of antioxidant enzyme SOD, CAT and GSH-PX, reduce the ROS levels, increase cell activity. By testing the apoptosis-related protein Bax, Bcl-2 and caspase-3, also proved that 10 μM SOG can improve ATO-induced cell apoptosis. So SOG can plays a role in detoxifying ATO cardiac toxicity.
Preparation and Dielectric Properties of Co Contained Unfilled Tungsten Bronze Ceramics Ba4RCo0.5Nb9.5O30
Authors: Guo Xiaoying , Zhang Weifeng , Wu Shan , Sun Chaozhong , Hu Changzheng , Liu Laijun , Fang Liang , Luo Nengneng 
Published: March 2021

Abstract
In this study, Ba4RCo0.5Nb9.5O30 (R = La, Nd, Sm, Eu) (BRCN) ceramics were synthesized using a high-temperature solid-state reaction. The effects of rare-earth ions with different ionic radii at A sites on the phase structure, microstructure, and dielectric properties of ceramics have been systematically studied. The full profile refinement XRD results show that all ceramic samples are tetragonal tungsten bronze (TTB). As the radius of the rare-earth ions decreases, the relaxation ferroelectric phase transition transforms into the dispersed phase transition, and the frequency dispersion of the ceramic samples gradually decreases. The high-frequency shift of Raman peak indicates that lattice distortion is severe. P-E loops under maximum applied electric field showed that BRCN ceramics can be used for energy storage.