bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Multidisciplinary Pre-Dialysis Care on the Outcomes of Incident Peritoneal Dialysis Patients
Authors: Wang I-Kuan , Yu Tung-Min , Yen Tzung-Hai , Yip Hei-Tung , Lai Ping-Chin , Li Chi-Yuan , Sun Kuo-Ting , Sung Fung-Chang 
Published: September 2021

Abstract
Background

This study aims to evaluate the impact of multidisciplinary pre-dialysis care (MDPC) on the risks of peritonitis, technique failure and mortality in peritoneal dialysis (PD) patients.
Methods

Incident end-stage renal disease patients who received peritoneal dialysis (PD) for more than 90 days were recruited in this study from 1 January 1, 2007 to December 31, 2018. Patients were classified into two groups, the MDPC group and the control group, that received the usual care by nephrologists. Risks of the first episode of peritonitis, technique failure and mortality were compared between the two groups.
Results

There were 126 patients under the usual care and 546 patients under the MDPC. Patients in the MDPC group initiated dialysis earlier than those in the non-MDPC group. There was no significant difference between these two groups in time to the first episode of peritonitis. Compared to the non-MDPC group, the MDPC group was at similar risks of technique failure (adjusted HR = 0.85, 95% CI = 0.64–1.15) and mortality (adjusted HR = 0.66, 95% CI = 0.42–1.02). Among patients with diabetes, the risk of mortality was significantly reduced in the MDPC group with an adjusted HR of 0.45 (95% CI = 0.25–0.80).
Conclusions

There was no significant difference in time to develop the first episode of peritonitis, and risks of technique failure and mortality between these two groups. Diabetic PD patients under MDPC had a lower risk of mortality than those under the usual care.
The epidemiological characteristics of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children’s Hospital
Authors: Lyu shuang , Shi Wei , Dong Fang , Xu Baoping , Liu Gang , Wang Quan , Yao Kaihu , Yang YongHong 
Published: September 2021

Abstract
Background : The epidemiological data of Streptococcus pneumoniae isolates are important for the practice of treatment and prevention. This research aimed to explore the epidemiological characteristics of pediatric S. pneumoniae isolated from outpatients and inpatients. Methods: S. pneumoniae were isolated from unsterile samples of inpatients and outpatients younger than five years old between March 2013 and February 2014. The serotypes were determined by diagnostic pneumococcal antisera, and resistance against 13 antibiotics was tested by either the E-test or the disc diffusion method. The sequence types (STs) were analyzed with multilocus sequence typing (MLST). Results: The five dominant serotypes obtained from inpatients were 19F(32.9%), 19A(20.7%), 23F(10.7%), 6A(10.0%), and 14 (8.6%), while those in the outpatients were 19F (13.6%), 23F (12.9%), 6A (10.0%), 6B (10.0%), and 19A (7.9%). The coverage rates of the 7-, 10- and 13-valent pneumococcal vaccine formulations were high. The non-susceptibility to penicillin, cefuroxime, imipenem, erythromycin, and trimethoprim-sulfamethoxazole among the inpatient isolates were 7.1%, 92.8%, 65.7%, 100%, and 85.0%, respectively, while those among the outpatient isolates were 0.7%, 50.0%, 38.6%, 96.4%, and 65.7%, respectively. There were 45 and 81 STs detected from the pneumococci isolated from inpatients and outpatients, respectively. CC271 was more prevalent in inpatients. Conclusions : The pneumococcal vaccine related serotypes were still prevalent either in inpatient department or in outpatient department, which with serious antibiotic resistance. These results might be helpful for understanding the epidemiology of S. pneumoniae in Beijing. PCVs can prevent vaccine related serotypes. Therefore, universal immunization of PCVs should be implemented to prevent the spread of vaccine related serotypes of S. pneumoniae .
MRI Assessment of Degeneration of Multifidus and Erector Spinae Muscles in Patients with Chronic Low Back Pain
Authors: Yazici Alikemal , Yerlikaya Tuba , Oniz Adile 
Published: September 2021

Abstract
Background

The aim of this study was to examine degeneration in the lumbar musculus multifidus (L.MF) and lumbar musculus erector spina (L.ES) muscles in patients with mechanical chronic low back pain, non-radiculopathy chronic low back pain with discopathy, and healthy individuals. The relationships with low back pain were examined by comparing the results according to gender, pain, and lumbar segments.
Material and Method:

Evaluation was made of 36 healthy control subjects (Group 1), 37 patients with mechanical low back pain (Group 2) and 41 non-radiculopathy, lumbar discopathy patients (Group 3). On axial magnetic resonance images at the L3-S1 level, asymmetry between the left and right sides was examined in respect of L.MF and L.ES surface cross-sectional areas (CSA), total surface cross-sectional area (TCSA = L.MF + L.ES), and fat infiltration.
Results

The mean CSA values showed a significant difference only in the right L.MF in the healthy control group (p = 0.011). No statistically significant difference was seen between the groups in the comparisons of TCSA, and a statistically significant difference was determined in respect of fat infiltration in the right and left L.MF and the left L.ES (p = 0.011, p = 0.001, p = 0.027, respectively). When the CSA and TCSA were examined according to gender within the groups, the values were found to be statistically significantly higher in males (p < 0.001). The CSA and TCSA values of the L.MF and L.ES showed a significant difference between segments (L3-L4, L4-L5, L5-S1) (p < 0.001). No asymmetry was observed between the left /right CSA and TCSA values of the groups. Fat infiltration showed a significant difference according to gender and segments (p < 0.001).
Conclusion

Fat infiltration in the L.MF muscle is related to mechanical low back pain and lumbar discopathy. That there was no difference between the groups in the CSA and TCSA values demonstrates the need for measurement of muscle atrophy associated with fat infiltration or functional cross-section area rather than CSA and TCSA.
Efficacy of Thunder-Fire Moxibustion In Treating Ankylosing Spondylitis of Kidney Deficiency And Governor Meridian Cold And Its Influence On Bone Metabolism：Study Protocol For A Randomized Controlled Trial
Authors: Liu Yang , Wang Pei , Sun Yanyan , Qu Jing , Li Min 
Published: September 2021

Abstract
Background: Ankylosing spondylitis(AS) is a common chronic inflammatory spondyloarthropathy,.It is considered in Traditional Chinese Medicine(TCM) that the pathogenesis of AS is mainly due to Yang deficiency of kidney governor meridian and internal prosperity of cold evil. Thunder-fire moxibustion is a kind of moxibustions and characterized in abundance in drug composition, high heat radiation and strong penetration. Thunder-fire moxibustion on spinal segment of governor meridian in treating AS seems compatible with the main pathogenesis of kidney deficiency and governor meridian cold. The Trial aims to explore the efficacy of thunder-fire moxibustion in patients with AS of kidney deficiency and governor meridian cold and its influence on bone metabolism, through a prospective randomized trial. Methods: Sixty patients with AS of kidney deficiency and governor meridian cold will be recruited and randomly assigned to the treatment group （thunder-fire moxibustion three times a week plus basic treatment）and the control group (basic treatment) at the Center of TCM of Beijing Luhe Hospital Affiliated to Capital Medical University (Beijing, China), Each patient will be treated for 4 weeks.Primary outcome indexes will include efficacy of TCM syndrome,Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI),with observation once respectively prior to the treatment, 2 weeks post to the treatment, and at the end of the treatment. Secondary outcome indexes will include tumor necrosis factor-α(TNF-α) and receptor activator of nuclear factor-κ B ligand(RANKL), which will be determined once respectively before and after treatment.Side effects during the treatments will be recorded and analyzed as well. Inter-group comparison and analysis will be performed based on intention-to-treat set and per-protocol set. Discussion: This prospective randomized trial will help verify the efficacy of thunder-fire moxibustion in treating AS of kidney deficiency and governor meridian cold, discuss preliminarily its mechanism in treating this disease, and provide high-quality evidences for scientific researches on clinical treatment with thunder-fire moxibustion against AS. Trial registration: Chinese Clinical Trial Registry, ChiCTR2100044227 . Registered on 12 March 2021.
Improved Gait Recognition Accuracy Based on DFT- GEI
Authors: Sriniva Lavanya 
Published: September 2021

Abstract
Person identification is a challenging task in computer vision. Identify a person from different cameras due to changes in appearance based on cofactors. Cofactors such as changing clothes, a suitcase, backpack, etc. The gait biometric is used to identify a person vary with different cofactors at different backgrounds. The person's gait can be identified at a distance, based on a walking pattern, without any physical contact. In this work, the videos are recorded using Infrared and Visible cameras at different locations such as urban and rural environments. The pre-processing includes the recorded videos are converted into frames, person identification using deep learning techniques, background subtraction, artifacts removal, silhouettes extraction, calculating gait cycle, and synthesis frequency domain gait energy image by averaging the silhouettes. The moving features are extracted from the frequency domain gait energy image and gait energy image are dimensionally reduced by principal component analysis, recognized using different classifiers and results are compared. Experiments are conducted on urban and rural datasets recorded using Long Wave Infrared and Visible cameras.
Optimizing the Treatment Mode for De Novo Metastatic Nasopharyngeal Carcinoma With Bone-only Metastasis
Authors: Lin Cheng , Lin Sheng , Zhu lili , Pan JianJi , Xu Yun , lin shaojun 
Published: September 2021

Abstract
Purpose: No standard radiotherapy regimens was established in the treatment of de novo metastatic nasopharyngeal carcinoma (mNPC) with bone-only metastasis. The current study aimed to investigate the efficacy of palliative chemotherapy (PCT) plus locoregional radiotherapy (LLRT) with or without local radiotherapy (RT) to bone metastatic lesions in mNPC, and identify the optimal candidates.Methods: We retrospectively analyzed 141 de novo mNPC patients with bone-only metastasis who received at least two cycles of PCT with or without LLRT and RT to bone metastasis. The difference in survival was evaluated by the log-rank test. Univariable and multivariable analysis was made by Cox regression. Results: Patients who received PCT plus LLRT had significantly longer overall survival (OS) (45.0 months vs 13.5 months, HR = 0.30 , p = 0.001) and progression-free survival (PFS) (29.0 months vs 11.0 months, HR = 0.34, p = 0.014), especially in patients who had less than 3 metastatic bone lesions. Multivariate analysis confirmed that LRRT, more chemotherapy cycles (≥ 4) and limited number of bone metastasis (≤ 3) were favorable prognostic factors for OS. Subgroup analysis revealed that RT to metastatic bones had a tendency to prolong the survival time in the unselected population who received PCT plus LLRT (p > 0.05), while further data suggested that RT to metastatic bones dramatically improve OS (72.0 months vs 26.0 months, p = 0.002) and PFS (60.0 months vs 20.0 months, p = 0.006) for mNPC with less than 3 metastatic bone lesions.Conclusions: LLRT and RT to bone metastatic lesions followed by PCT in de novo mNPC with bone-only metastasis significantly prolonged survival in patients with less than 3 metastatic bone lesions.
Exosomes Derived from miR-214-3p Overexpressing Mesenchymal Stem Cells Promote Myocardial Repair
Authors: Zhu Wenwu , Wang Qingjie , Zhang Jian , Sun Ling , Du Wei , Wu Yujie , Cao Yue , Chi Boyu , Li Jing , Feng Yueyue , Zou Ailin , Mao Lipeng , Jiang Jianguang , Ji Yuan , Han Bing 
Published: September 2021

Abstract
Aims Exosomes are known as nanovesicles that are naturally secreted，playing an essential role in stem-mediated cardioprotection. This study mainly focused on investigating if exosomes derived from miR-214 overexpressing mesenchymal stem cells (MSCs) show more valid cardioprotective ability in a rat model of acute myocardial infarction (AMI) and its potential mechanisms.Methods Exosomes were isolated from control MSCs (Ctrl-Exo) and miR-214 overexpressing MSCs (miR-214OE-Exo) and then they were delivered to cardiomyocytes and endothelial cells in vitro under hypoxia and serum deprivation (H/SD) condition or in vivo in an acutely infarcted Sprague-Dawley rat heart. Regulated genes and signal pathways by miR-214OE-Exo treatment were explored using western blot analysis and luciferase assay.Results In vitro, miR-214OE-Exo enhanced migration, tube-like formation in endothelial cells. In addition, miR-214OE-Exo ameliorated the survival of cardiomyocytes under H/SD. In the rat AMI model, compared to Ctrl-Exo, miR-214OE-Exo reduced myocardial apoptosis, and therefore reduced infarct size and improved cardiac function. Besides, miR-214OE-Exo accelerated angiogenesis in peri-infarct region. Mechanistically, we identified that exosomal miR-214-3p promoted cardiac repair via targeting PTEN and activating p-AKT signal pathway. Conclusion Exosomes derived from miR-214 overexpressing MSCs have greatly strengthened the therapeutic efficacy for treatment of AMI by promoting cardiomyocyte survival and endothelial cell function.
The Effects of Press Needle on Immune Function and Quality of Life Among Female Breast Cancer Patients After Radical Mastectomy: Study Protocol for a Randomised Controlled Trial
Authors: Gao Ying , Wang Yao , Chen Hongchu , Yan Ran , Liu Tao , Li Zhuohong , Zeng Jinhao 
Published: September 2021

Abstract
BackgroundRadical mastectomy may lead to suppression of cellular immune function in patients with malignant tumors, and affect the quality of life (QOL) of patients. Immune suppression is a common cause of complications and adverse reactions in adjuvant therapy after radical mastectomy of breast cancer. Currently, there are few proven effective treatments for immune suppression. Therefore, it’s necessary to develop a new treatment method. Press needle is widely used in clinical practice. However, there have been relatively few studies that evaluate the effects of press needle on postoperative immune function. The aim of the present study is to assess the effects of press needle on immune function and QOL in female breast cancer patients undergoing radical mastectomy.MethodsThis study will be a single-center, randomized and single-blinded trial. 78 eligible patients will be randomized in a ratio of 1:1 to the press needle group or the sham press needle group. During the treatment phase, patients will undergo five times weekly of verum press needle or sham press needle for 2 weeks, and then they will be followed-up for 2 weeks. The primary outcome measures will be the peripheral blood levels of CD8+, CD4+, CD3+, and CD4+/CD8+ T cells. The secondary outcome measures will be the changes of patients’ QOL, evaluated by the Karnofsky Performance Scale (KPS) score and the EORTC core quality of life questionnaire (EORTC QLQ-C30). Safety and adverse events will be assessed at each visit. DiscussionThe results of this on-going study will provide clinical evidence for the effects and safety of press needle on immune function and QOL in patients after breast cancer resection compared with sham press needle.Trial registrationChinese Clinical Trial Registry, ChiCTR2000040100. Registered on 21 November 2020.
FOXO3a-ROS Pathway is Involved in Androgen-Induced Proliferation of Prostate Cancer Cell
Authors: Tao Yan , Lu Jianzhong , Fu Shengjun , Li Lanlan , Liu Shanhui , Zhang Jing , Wang Zhiping , Hong Mei 
Published: September 2021

Abstract
Background: Although FOXO3a can inhibit the cell proliferation of prostate cancer, its relationship with reactive oxygen species (ROS) in prostate cancer(PCa) has not been reported. Methods: We analyzed the correlation between the expression of FOXO3a and the antioxidant enzyme catalase in prostate cancer through the UALCAN and GEPIA databases. We also constructed a PPI network of FOXO3a via the STRING database. The mRNA and protein expression of FOXO3a and catalase in LNCaP cells after DHT treatment were detected by qRT-PCR and western blot analysis. The effects of FOXO3a on catalase expression were tested by over-expression and siRNA interference respectively. At the same time, the catalase activity and ROS level in LNCaP cells after DHT treatment were detected. The changes of cell proliferation and ROS in LNCaP by antioxidant were also analyzed.Results: We found that the catalase expression was down-regulated and has positively correlation with FOXO3a in PCa by public databases. The results of qRT-PCR and western blot showed that the mRNA and protein expression of FOXO3a and catalase were significantly reduced after DHT treatment in the LNCaP cells. Over-expression and knockdown of FOXO3a can also induce the change of catalase expression. DHT treatment can inhibit catalase activity and increase ROS level. We found that antioxidant treatment reduced DHT-induced proliferation and ROS production.Conclusions: Our data show that the mechanisms by which DHT promotes PCa cell proliferation is that FOXO3a suppresses catalase expression and activates ROS signaling.
Clinicopathological Features, Clinical Efficacy on 101 Cases of Rectal Gastrointestinal Stromal Tumors, and the Significance of Neoadjuvant Therapy
Authors: Yang Hongxin , Shen Chaoyong , Yin Xiaonan , Cai Zhaolun , Wang Qian , Zhang Bo 
Published: September 2021

Abstract
Objective: To investigate the clinicopathological features, clinical efficacy on 101 cases of rectal gastrointestinal stromal tumors (GISTs), and the significance of Imatinib Mesylate (IM) neoadjuvant therapy.Methods: The clinicopathological features, treatment methods, peri-operative data, and prognosis of the patients were summarized and analyzed on 101 patients with rectal GISTs, who received treatment in the Gastrointestinal Department of West China Hospital of SichuanUniversity and the Affiliated Hospital of Guizhou Medical University from August 2002 toNovember 2020 in China. Results: A total of 101 patients, including 64 males and 37 females, were aged from 22 to 79 years (55.4±12.2 years). Among 70 patients with direct surgery, which included 8 very low risk cases, 10 low risk cases, 7 intermediate risk cases, and 45 high risk cases. Cox regression analysis showed that post-operative IM adjuvant treatment improved disease-free survival (DFS) and overall survival (OS) of 52 intermediate and high risk patients. Among the 31 patients who received neoadjuvant therapy, the objective response rate (ORR) was 83.9% (26/31), and the disease control rate (DCR) reached 96.8% (30/31). Diameter subgroup analysis: (1) Among the 36 patients with a diameter ≤ 5 cm, two patients received IM neoadjuvant therapy, while 34 patients received direct surgery. Both univariate and Cox regression analysis did not find that neoadjuvant therapy affects DFS and OS. (2) Among the 65 patients of diameter >5 cm, 29 received IM neoadjuvant therapy and 36 received direct surgery. Patients who underwent neoadjuvant therapy had less blood loss (P=0.022) , shorter post-operative hospital stay (P=0.001), increased anal preservation proportion (93.1% VS72.2% , P=0.031), decreased enterostomy proportion (10.3% VS 33.3%, P=0.037) than those who underwent direct surgery. Cox regression analysis suggested that neoadjuvant therapy and post-operative IM adjuvant therapy improved DFS. Conclusion: Rectal GISTs is relatively rare and is a highly malignant tumor, post-operative oral IM therapy can improve DFS and OS of intermediate and high risk patients. In patients with rectal GISTs with diameter > 5 cm, IM neoadjuvant therapy can improve the anal preservation proportion , preserve the structure and function of the organs, reduce enterostomy proportion, and improve prognosis.
The Effect of Combined Internet Diet Behavior Intervention On School-Age Children
Authors: Zhang Xueyan , Liu Xiaoran , Gao Lin , Li Xiaomei 
Published: September 2021

Abstract
Background

With the development of the economy and the improvement of people's quality of life, the problem of children's eating behavior is a common phenomenon. The purpose of this study was to evaluate the effect of combined internet dietary behavior intervention on the dietary behavior of school-age children.
Methods

A randomized controlled trial (RCT) was conducted among school-age children aged 6–12 years and their parents. A total of 480 children participated, 240 in the experimental group and 240 in the control group. The children in the experimental group were given dietary behavior intervention for 2 months. The intervention was conducted through face-to-face lectures and WeChat; the children in the control group did not make any intervention. The school-age children’s eating behavior scale (CSCEBQ) was used to evaluate the eating behavior of all children at baseline and 2 months. The rank-sum test and X2 test were used to analyze the data.
Results

At baseline, the experimental group and the control group had no significant differences in the scores of the six dimensions of food fussiness, food responsiveness, satiety responsiveness, unhealthy eating habits, external eating, craving for junk food (p > 0.05). After 2 months, in addition to the food preference dimension, the dietary behavior scores of the children in the experimental group were significantly lower than those in the control group in other dimensions (p ≤ 0.01).
Conclusions

Compared with the control group, the children in the experimental group improved in food fussiness, food responsiveness, unhealthy eating habits, external eating, dietary restriction, craving for junk food. This study increases the knowledge of using WeChat to intervene, and evaluated the impact of using CSCEBQ on children’s diet, and provides a more scientific and effective basis for the clinical intervention of children with eating behavior problems.