bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of sagittal synostosis in the Synostosis Research Group: baseline data and early outcomes
Authors: Baker Cordell M. , Ravindra Vijay M. , Gociman Barbu , Siddiqi Faizi A. , Goldstein Jesse A. , Smyth Matthew D. , Lee Amy , Anderson Richard C. E. , Patel Kamlesh B. , Birgfeld Craig , Pollack Ian F. , Imahiyerobo Thomas , Kestle John R. W. , _ _ 
Published: April 2021

OBJECTIVE
Sagittal synostosis is the most common form of isolated craniosynostosis. Although some centers have reported extensive experience with this condition, most reports have focused on a single center. In 2017, the Synostosis Research Group (SynRG), a multicenter collaborative network, was formed to study craniosynostosis. Here, the authors report their early experience with treating sagittal synostosis in the network. The goals were to describe practice patterns, identify variations, and generate hypotheses for future research.

METHODS
All patients with a clinical diagnosis of isolated sagittal synostosis who presented to a SynRG center between March 1, 2017, and October 31, 2019, were included. Follow-up information through October 31, 2020, was included. Data extracted from the prospectively maintained SynRG registry included baseline parameters, surgical adjuncts and techniques, complications prior to discharge, and indications for reoperation. Data analysis was descriptive, using frequencies for categorical variables and means and medians for continuous variables.

RESULTS
Two hundred five patients had treatment for sagittal synostosis at 5 different sites. One hundred twenty-six patients were treated with strip craniectomy and 79 patients with total cranial vault remodeling. The most common strip craniectomy was wide craniectomy with parietal wedge osteotomies (44%), and the most common cranial vault remodeling procedure was total vault remodeling without forehead remodeling (63%). Preoperative mean cephalic indices (CIs) were similar between treatment groups: 0.69 for strip craniectomy and 0.68 for cranial vault remodeling. Thirteen percent of patients had other health problems. In the cranial vault cohort, 81% of patients who received tranexamic acid required a transfusion compared with 94% of patients who did not receive tranexamic acid. The rates of complication were low in all treatment groups. Five patients (2%) had an unintended reoperation. The mean change in CI was 0.09 for strip craniectomy and 0.06 for cranial vault remodeling; wide craniectomy resulted in a greater change in CI in the strip craniectomy group.

CONCLUSIONS
The baseline severity of scaphocephaly was similar across procedures and sites. Treatment methods varied, but cranial vault remodeling and strip craniectomy both resulted in satisfactory postoperative CIs. Use of tranexamic acid may reduce the need for transfusion in cranial vault cases. The wide craniectomy technique for strip craniectomy seemed to be associated with change in CI. Both findings seem amenable to testing in a randomized controlled trial.
Rancang Bangun Sistem Informasi Aplikasi Sales Report Berbasis Web
Authors: Apriani Desy , Anwar Rismawan Syaiful , Al Hamzah Robby 
Published: April 2021

The development of technology is currently considered very rapidly developing, especially in the industrial field. Competition in the industrial world is getting tougher so that the company will always try to continue to be the first in satisfying the company's partners so they do not switch to another. In carrying out reporting, Sales Report still uses office-based applications, namely Microsoft Excel, which results in suboptimal performance results. Then a web-based Sales Report application system was built. In determining research and research design requires a method to see the development of the design and research, the methods applied include the SWOT method (Strength, Weakness, Opportunities, Threat) and are designed using PHP and MySQL programming as a database.
Rancang Bangun Sistem Persediaan Alat Tulis Kantor Berbasis Web Pada Perumdam Tirta Kerta Raharja Kabupaten Tangerang
Authors: Azizah Nur , Rahayu Nurlaila Suci , Anjani Dewi 
Published: April 2021

An office stationery inventory system that is accurate and up to date is needed by the company. In the process of stationery inventory of the Tirta Kerta Raharja District Office in Tangerang Regency, which is done at this time is still manual so it is less effective, because the warehouse sub-section utilizes office stationery inventory documents in the form of submission forms and inputs office stationery inventory data manually so that the monitoring process is difficult and vulnerable to loss or damage to documents. Therefore, it is necessary to design a computerized web-based office stationery inventory information system in order to facilitate its users. With the computerized web- based office stationery inventory system can facilitate the warehouse subsection in inputting data so that inventory monitoring is carried out regularly to make it more accurate and optimal. Data collection methods are done by observation, interviews, and literature studies from various studies, while the system analysis method is done using the PIECES method and the design method uses UML (Unified Modeling Language) and PHP programming language and MysQL as a database. This is the rationale for how researchers analyze the existing office stationery inventory system at the Tirta Kerta Raharja Public Corporation in the District of Tangeran so that it can facilitate the performance to be more effective, efficient and accurate.
Sistem Informasi E-Guest Book Pada PT. Halliburton Indonesia
Authors: Nugroho Tri Cahyo , Yulandha Nadia , Nurazizah Nurazizah 
Published: April 2021

Sistem informasi adalah satu dari beberapa dari teknologi yang sangat diperlukan oleh perusahaan atau Instansi untuk melakukan pengolahan data sebagimana data merupakan aset terpenting untuk perusahaan. Dalam meningkatkan kualitas PT. Halliburton Indonesia untuk mempermudah Real Astate Team dalam mengolah data tamu, maka pembutan Buku tamu berbasis Web diperlukan. Pada sistem yang berjalan saat ini petugas mengalami kesulitan untukmemproses data pengunjung pada PT. Halliburton Indonesia. Meskipun sudah menggunakan teknologi komputer sebagai sarana dalam pengolahan data, namun dalam mengolah data buku tamu masih dilakukan secara manual kedalam berkas. Dari masalah yang dijelaskan maka data mengenai tamu masih banyak terjadi kesalahan, kurang akurat, tidak up to date dan masih terjadi keterlambatan dalam membuat dan menyampaikan laporan kepada pimpinan. Padapenelitian ini, penelitian menggunakan metode pengumpulan data yaitu: observasi, wawancara, dan literatur review (studi pustaka). Dalam analisis menggunakan metode analisis PIECES. Selanjutnya, design sistem yang berjalan menggunakan Unified Modeling Language (UML) diantaranya: Use Case diagram, Activity diagram dan, Sequence diagram, Bahasa Pemrograman menggunakan PHP, MySQL sebagai database dan Sublime Text 3 untuk TextEditor. Hasil dari penelitian adalah berupa Sistem Informasi Buku tamu secara terdatabase atau berbasis Web dapat memudahkan petugas untuk mencari data serta menghasilkan data yang lebih akurat.
Kata Kunci: Sistem Informasi, E-Guest Book, Web
Sistem Informasi Penjadwalan Rapat Kerja Pada Perumdam Tirta Kerta Raharja Kabupaten Tangerang
Authors: Pramono Bayu , Tiara Anggun W Ayu Fadhilah , Yasyfa Lina 
Published: April 2021

Perumdam Tirta Kerta Raharja Kabupaten tangerang merupakan sebuah perusahaan air minum daerah yang dimiliki pemerintah kabupaten tangerang, yang bergerak di bidang Air Bersih. Penjadwalan ruang rapat pada Perumdam Tirta Kerta Raharja Kabupaten Tangerang tersendiri masih menggunakan form undangan dan nota dinas pada saat pengajuan, sehingga unit kerja harus bertemu langsung dengan bagian rumah tangga untuk menyerahkan form tersebut. Tujuan penelitian merupakan Sistem yang masih tergolong rumit dan tidak efektif dikarenakan membutuhkan waktu lama untuk berkoordinasi dengan bagian rumah tangga secara langsung sedangkan jika tidak melakukan koordinasi tersebut akan terjadinya jadwal bentrok. Maka untuk mengatasi hal tersebut dibutuhkannya sistem penjadwalan yang terkomputerisasi dengan baik agar kinerja tersebut lebih efektif dan efisien sehingga tidak terjadinya jadwal bentrok. Hasil mengenai penelitian dini merupakan website mengenai Penjadwalan ruang rapat secara terdatabase atau berbasis web dapat memudahkan Rumah tangga dalam mengontrol penjadwalan dan Unit kerja dalam melaksanakan rapat. Sehingga dengan sistem digital diharapkan mampu memudahkan alur penjadwalan ruang rapat.
Kata Kunci: Penjadwalan ruang rapat kerja, Koordinasi, dan Komputerisasi.
Aplikasi Kasir Digital dan Perhitungan Pembayaran Pajak Penghasilan UMKM Berbasis Android
Authors: Rahayu Eka Fitri , Fandhika Fandhika , Santoso Sugeng 
Published: April 2021

Pada masa sekarang, smartphone sudah menjadi bagian dari kehidupan kita sehari- hari, perkembangannya pun terjadi sangat pesat pada beberapa tahun belakangan ini. Hampir semua bidang industri beralih dari sistem konvensional menjadi sistem digital, terutama pada bidang industri ekonomi yang besar. Tetapi para pelaku UMKM masih menggunakan sistem konvensional pada transaksi mereka. Tujuan dari penelitian ini untuk membuat Aplikasi Kasir Digital dan Perhitungan Pembayaran Pajak Penghasilan UMKM Berbasis Android. Metode penelitian yang digunakan meliputi perencanaan, analisis, perancangan, pembuatan, serta implementasi dan uji coba. Pada tahap perancangan menggunakan struktur navigasi sebagai alur dari aplikasi, serta Use Case Diagram danActivity Diagram untuk penggambaran sistem. Untuk pembuatan aplikasi kasir dan perhitungan pembayaran pajak ini menggunakan bahasa pemrograman Java dan menggunakan Firebase sebagai databasenya. Pada tahap akhir melakukan implementasi dan uji coba aplikasi. Hasil implementasi dan uji coba aplikasi ini menggunakan metode Black Box dan dapat berjalan dengan baik.
Kata Kunci : Aplikasi Kasir, Pajak, UMKM, Android, Firebase
circ_0003204 Regulates Cell Growth, Oxidative Stress, and Inflammation in ox-LDL-Induced Vascular Endothelial Cells via Regulating miR-942-5p/HDAC9 Axis
Authors: Wan Huan , You Ting , Luo Wei 
Published: April 2021

Background: Atherosclerosis (AS) is a typical inflammatory vascular disease. Many reports corroborated that circular RNAs (circRNAs) is involved in AS progression. However, the potential function and possible mechanism of circ_0003204 in AS progression remain indistinct.Methods: Expression level analysis was performed using qRT-PCR and western blot. Cell viability and apoptosis were determined using Cell Counting Kit-8 (CCK-8), flow cytometry, and western blot assays. The status of oxidative stress and inflammation was determined via commercial detection kits and ELISA assay, respectively. The binding relationship was verified via dual-luciferase reporter and RNA immunoprecipitation assays.Results: ox-LDL increased circ_0003204 and HDAC9 levels and decreased miR-942-5p level. Silencing of circ_0003204 enhanced cell viability and inhibited cell apoptosis, oxidative stress and inflammation in ox-LDL-disposed HUVECs. In addition, circ_0003204 targeted miR-942-5p to regulate ox-LDL-resulted HUVECs injury. Also, miR-942-5p affected ox-LDL-triggered HUVECs injury by targeting HDAC9. Furthermore, circ_0003204 elevated HDAC9 expression via decoying miR-942-5p.Conclusion: circ_0003204 aggravated ox-LDL-induced HUVECs damage via modulating miR-942-5p/HDAC9 pathway.
Structural Style and Kinematic History of the Colombian Eastern Cordillera
Authors: Costantino Diego , Paton Douglas , Mora Andrés 
Published: April 2021

Fold-and-thrust belts and their associated structures are among the most common geological features of convergent margins. They provide significant information about crustal shortening and mountain-building processes. In subaerial belts, where the erosional rates are high and the growth strata are mostly eroded, methodologies such as that presented here can provide insights into to their formation. Two 2D cross-sections located in the Eastern Cordillera of Colombia are presented in this research. These sections extend from the Bogota Savanna to The Llanos, parallel to the regional deformation direction. Section construction was carried out using commercial surface data, and seismic information provided by Ecopetrol. Published thermochronometric data, gravel-clast petrography analysis, and paleoflora analysis were used to construct a viable tectono-evolutionary history of the study area. This evolutionary model is presented here in two palinpastic restorations from the Early Paleogene to Recent (∼65 Ma to Present-day). Section 1 and Section 10 accumulated 17.3 km and 19.5 km of shortening, respectively. The section reconstruction displays two major tectonic events – post-rift subsidence during the Early-Mid Paleogene, and positive inversion from the Oligocene to Recent (∼33 Ma to Present-day). This investigation focuses on the compressional period, where the structural analysis evidences an acceleration in the shortening rate, as well as a progressive migration of the deformation from northwest to southeast. This research discusses the extent and limitation of this methodology, as well as the principal structural aspects of the reconstruction.
Case Report: Combination Therapy With PD-1 Blockade for Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation Resulted in Fatal GVHD
Authors: Yao Sun , Jianlin Chen , Zhuoqing Qiao , Yuhang Li , Jiangwei Hu , Guoliang Hu , Hongmei Ning , Bin Zhang , Liangding Hu 
Published: April 2021

Background:Azacitidine is commonly used in the treatment of relapsed acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the effectiveness of this monotherapy is still very low. A possible mechanism of resistance to hypomethylating agents (HMAs) is the upregulation of the expression of inhibitory checkpoint receptors and their ligands, making the combination of HMAs and immune checkpoint blockade therapy a rational approach. Although the safety of anti-programmed cell death protein (PD)-1 antibodies for patients with post-allo-HSCT remains a complicated issue, the preliminary clinical result of combining azacitidine with anti-PD-1 antibodies is encouraging; however, the safety and efficacy of this approach need further investigation.Case Presentation:We reported a case of treated secondary (ts)-AML in a patient who received tislelizumab (an anti-PD-1 antibody) in combination with azacitidine. The patient relapsed after allo-HSCT and was previously exposed to HMAs-based therapy. The patient received tislelizumab for compassionate use. After the combination treatment, the patient achieved complete remission with incomplete hematologic recovery, negative minimal residual disease (MRD) by flow cytometry (FCM), and negative Wilms' tumor protein 1 (WT1). However, the patient successively developed serious immune-related adverse events (irAEs) and graft vs. host disease (GVHD) and eventually died from complications of GVHD.Conclusion:To our knowledge, this is the first case to report the combined use of tislelizumab and azacitidine to treat relapsed AML posttransplantation. This report highlights the safety concerns of using an anti-PD-1 antibody in combination with azacitidine after allo-HSCT, especially the risk of GVHD, and provides a basis for future studies.
Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury
Authors: Wu Miaomiao , Rowe Jennifer M. , Fleming Sherry D. 
Published: April 2021

Intestinal ischemia reperfusion (IR)-induced tissue injury represents an acute inflammatory response with significant morbidity and mortality. The mechanism of IR-induced injury is not fully elucidated, but recent studies suggest a critical role for complement activation and for differences between sexes. To test the hypothesis that complement initiation differs by sex in intestinal IR, we performed intestinal IR on male and female WT C57B6L/, C1q-/-, MBL-/-, or properdin (P)-/-mice. Intestinal injury, C3b and C5a production andex vivosecretions were analyzed. Initial studies demonstrated a difference in complement mRNA and protein in male and female WT mice. In response to IR, male C1q-, MBL- and P-deficient mice sustained less injury than male WT mice. In contrast, only female MBL-/-mice sustained significantly less injury than female wildtype mice. Importantly, wildtype, C1q-/-and P-/-female mice sustained significant less injury than the corresponding male mice. In addition, both C1q and MBL expression and deposition increased in WT male mice, while only elevated MBL expression and deposition occurred in WT female mice. These data suggested that males use both C1q and MBL pathways, while females tend to depend on lectin pathway during intestinal IR. Females produced significantly less serum C5a in MBL-/-and P-/-mice. Our findings suggested that complement activation plays a critical role in intestinal IR in a sex-dependent manner.
Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment
Authors: Wang Weinan , Zou Rui , Qiu Ye , Liu Jishuang , Xin Yu , He Tianzhu , Qiu Zhidong 
Published: April 2021

Granzyme B is a renowned effector molecule primarily utilized by CTLs and NK cells against ill-defined and/or transformed cells during immunosurveillance. The overall expression of granzyme B within tumor microenvironment has been well-established as a prognostic marker indicative of priming immunity for a long time. Until recent years, increasing immunosuppressive effects of granzyme B are unveiled in the setting of different immunological context. The accumulative evidence confounded the roles of granzyme B in immune responses, thereby arousing great interests in characterizing detailed feature of granzyme B-positive niche. In this paper, the granzyme B-related regulatory effects of major suppressor cells as well as the tumor microenvironment that defines such functionalities were longitudinally summarized and discussed. Multiplex networks were built upon the interactions among different transcriptional factors, cytokines, and chemokines that regarded to the initiation and regulation of granzyme B-mediated immunosuppression. The conclusions and prospect may facilitate better interpretations of the clinical significance of granzyme B, guiding the rational development of therapeutic regimen and diagnostic probes for anti-tumor purposes.
Changes in Walking Speed After High-Intensity Treadmill Training Are Independent of Changes in Spatiotemporal Symmetry After Stroke
Authors: Cleland Brice , Madhavan Sangeetha 
Published: April 2021

Objectives: Decreased walking speeds and spatiotemporal asymmetry both occur after stroke, but it is unclear whether and how they are related. It is also unclear whether rehabilitation-induced improvements in walking speed are associated with improvements in symmetry or greater asymmetry. High-intensity speed-based treadmill training (HISTT) is a recent rehabilitative strategy whose effects on symmetry are unclear. The purpose of this study was to: (1) assess whether walking speed is cross-sectionally associated with spatiotemporal symmetry in chronic stroke, (2) determine whether HISTT leads to changes in the spatiotemporal symmetry of walking, and (3) evaluate whether HISTT-induced changes in walking speed are associated with changes in spatiotemporal symmetry.Methods: Eighty-one participants with chronic stroke performed 4 weeks of HISTT. At pre, post, and 3-month follow-up assessments, comfortable and maximal walking speed were measured with the 10-meter walk test, and spatiotemporal characteristics of walking were measured with the GAITRite mat. Step length and swing time were expressed as symmetry ratios (paretic/non-paretic). Changes in walking speed and symmetry were calculated and the association was determined.Results: At pre-assessment, step length and swing time asymmetries were present (p &lt; 0.001). Greater temporal symmetry was associated with faster walking speeds (p ≤ 0.001). After HISTT, walking speeds increased from pre-assessment to post-assessment and follow-up (p ≤ 0.002). There were no changes in spatiotemporal symmetry (p ≥ 0.10). Change in walking speed was not associated with change in spatial or temporal symmetry from pre- to post-assessment or from post-assessment to follow-up (R2 ≤ 0.01, p ≥ 0.37).Conclusions: HISTT improves walking speed but does not systematically improve or worsen spatiotemporal symmetry. Clinicians may need to pair walking interventions like HISTT with another intervention designed to improve walking symmetry simultaneously. The cross-sectional relation between temporal symmetry and walking speed may be mediated by other factors, and not be causative.
Association of Trimethylamine N-Oxide and Its Precursor With Cerebral Small Vessel Imaging Markers
Authors: Chen Yiyi , Xu Jie , Pan Yuesong , Yan Hongyi , Jing Jing , Yang Yingying , Wang Xing , Wan Huijuan , Gao Ying , Han Shangrong , Zhong Xi , Liu Chenhui , Pi Jingtao , Li Zhengyang , Luo Biyang , Wang Guangyao , Zhao Yilong , Wang Nan , Lin Jinxi , Meng Xia , Zhao Xingquan , Liu Liping , Li Wei , Jiang Yong , Li Zixiao , Zhang Xinmiao , Yang Xiaomeng , Ji Ruijun , Wang Chunjuan , Li Hao , Wang Penglian , Zheng Huaguang , Ji Weizhong , Cai Xueli , Wu Songdi , Han Xinsheng , Wang Yongjun , Wang Yilong 
Published: April 2021

Background: High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds.Methods: We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. The data were collected from 30 hospitals in China and included 1,098 patients with ischemic stroke/transient ischemic attack aged ≥18 years. White matter hyperintensities, lacunes, and cerebral microbleeds were evaluated with the patients' demographic, clinical, and laboratory information removed. White matter hyperintensities were rated using the Fazekas visual grading scale, while the degree of severity of the lacunes and cerebral microbleeds was defined by the number of lesions.Results: Increased TMAO levels were associated with severe white matter hyperintensities [adjusted odds ratio (aOR) for the highest vs. lowest quartile, 1.5; 95% confidence interval (CI), 1.0–2.1, p = 0.04]. High TMAO levels were more strongly associated with severe periventricular white matter hyperintensities (aOR for the highest vs. lowest quartile, 1.6; 95% CI, 1.1–2.3, p = 0.009) than deep white matter hyperintensities (aOR for the highest vs. lowest quartile, 1.3; 95% CI, 0.9–1.9, p = 0.16). No significant association was observed between TMAO and lacunes or cerebral microbleeds. Choline showed trends similar to that of TMAO in the association with cerebral small vessel disease.Conclusions: In patients with ischemic stroke or transient ischemic attack, TMAO and choline appear to be associated with white matter hyperintensities, but not with lacunes or cerebral microbleeds; TMAO and choline were associated with increased risk of a greater periventricular, rather than deep, white matter hyperintensities burden.