bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimising predictive modelling of Ross River virus using meteorological variables
Authors: Koolhof Iain S. , Firestone Simon M. , Bettiol Silvana , Charleston Michael , Gibney Katherine B. , Neville Peter J. , Jardine Andrew , Carver Scott 
Published: March 2021

Background
Statistical models are regularly used in the forecasting and surveillance of infectious diseases to guide public health. Variable selection assists in determining factors associated with disease transmission, however, often overlooked in this process is the evaluation and suitability of the statistical model used in forecasting disease transmission and outbreaks. Here we aim to evaluate several modelling methods to optimise predictive modelling of Ross River virus (RRV) disease notifications and outbreaks in epidemiological important regions of Victoria and Western Australia.

Methodology/Principal findings
We developed several statistical methods using meteorological and RRV surveillance data from July 2000 until June 2018 in Victoria and from July 1991 until June 2018 in Western Australia. Models were developed for 11 Local Government Areas (LGAs) in Victoria and seven LGAs in Western Australia. We found generalised additive models and generalised boosted regression models, and generalised additive models and negative binomial models to be the best fit models when predicting RRV outbreaks and notifications, respectively. No association was found with a model’s ability to predict RRV notifications in LGAs with greater RRV activity, or for outbreak predictions to have a higher accuracy in LGAs with greater RRV notifications. Moreover, we assessed the use of factor analysis to generate independent variables used in predictive modelling. In the majority of LGAs, this method did not result in better model predictive performance.

Conclusions/Significance
We demonstrate that models which are developed and used for predicting disease notifications may not be suitable for predicting disease outbreaks, or vice versa. Furthermore, poor predictive performance in modelling disease transmissions may be the result of inappropriate model selection methods. Our findings provide approaches and methods to facilitate the selection of the best fit statistical model for predicting mosquito-borne disease notifications and outbreaks used for disease surveillance.
RESOLUSI KONFLIK KEAGAMAAN INTEGRATIF: STUDI ATAS RESOLUSI KONFLIK SOSIAL KEAGAMAAN AMBON
Authors: Ismail Roni 
Published: March 2021

Penelitian ini bertujuan untuk menganalisis resolusi konflik yang ditempuh dalam penyelesaian konflik sosial keagamaan Ambon. Melalui wawancara dan dokumentasi dari 2017-2019 dengan berbagai kalangan warga Ambon Muslim dan Kristen, ditambah kajian literatur riset sejenis, ditemukan peneliti bahwa penyelesaian konflik Ambon ditempuh dengan resolusi konflik integratif. Resolusi konflik integratif merupakan sebuah model resolusi konflik yang mengintegrasikan resolusi struktural dan resolusi kultural secara bersamaan sebagai kesatuan yang tidak terpisahkan. Dengan kerangka teoritik demikian diperoleh data dan informasi bahwa resolusi konflik struktural, untuk menyelesaikan akar-akar konflik Ambon di luar aspek keagamaan, ditempuh dengan: pendekatan keamanan seperti menambah personil keamanan sampai 11.250 personil, peningkatan Korem menjadi Kodam Maluku, dan pemberlakukan darurat sipil; peran Pemerintah dalam Perjanjian Damai Malino II; Sharing kepemimpinan politik Muslim-Kristen dalam kontestasi pemilihan Gubernur, Walikota dan Bupati; dan sharing jabatan birokrasi dengan SKJ. Sedangkan resolusi konflik kultural, ditempuh untuk menyelesaikan akar-akar konflik yang bersifat keagamaan, yaitu: revitalisasi multikulturalisme oleh pendidikan tinggi keagamaan negeri IAIN dan IAKN Ambon; revitalisasi nilai damai agama melalui agamawan Kristen-Muslim melalui dialog bersama, kerjasama, rekonsiliasi, pela-gandong salam-sarani, dan deradikalisasi; optimalisasi peran FKUB dalam dialog kehidupan; dan, revitalisasi pela gandong antar kampung-kampung Muslim dan Kristen. Resolusi konflik integratif diakui warga Ambon Muslim dan Kristen sangat efektif menyelesaikan akar-akar konflik di Ambon sehingga terbangun fondasi damai yang kokoh di Ambon. Pada tahun 2019 Ambon pun berhasil mendapat Harmony Award dari Menteri Agama RI.
Habitar el cuerpo abyecto: realización escénica a partir de un laboratorio escénico
Authors: Méndez Ramírez Amanda 
Published: March 2021

Esta investigación artística persigue la conceptualización del cuerpo abyecto, comprendido de forma teórica y escénica. Se divide en tres partes: un estudio teórico, un laboratorio escénico y un montaje/desmontaje escénico. Se sustenta teóricamente con el trabajo de Judith Butler: Cuerpos que importan, sobre los límites materiales y discursivos del sexo (2008), Julia Kristeva: Poderes del horror. Sobre la abyección (1988); la metodología se sustenta en el texto de Ericka Fischer-Lichte: Estética de lo performativo (2017). La investigación culmina con la creación de una dramaturgia corporal a partir de lo creado en el laboratorio escénico, y un breve desmontaje del proceso de creación e investigación escénica. Entre los principales hallazgos se rescata la comprensión y estudio escénico de un concepto, la posibilidad del arte escénicopara generar nuevo conocimiento y las posibilidades expresivas del cuerpo en escena.
El cuerpo: aproximaciones heterodoxas
Authors: Cáceres Juan Fernando , Olivier Toledo Carlos , Olvera Rabadán Alejandra , Céspedes Ronald 
Published: March 2021

Vivimos en la era del cuerpo. No sabemos hasta cuándo el mundo académico mantendrá el interés, sin embargo, nadie podrá dudar que en la actualidad el cuerpo es parte, ya sea como accesorio o como objeto principal, de la mayoría de los estudiosacadémicos. Desde el mundo de las artes hasta el de las ciencias, se ha reconocido que sin él no es posible comprender del todo al hombre vivo, al hombre de carne y hueso… al hombre total. En efecto, “puesto que nuestros cuerpos −afirmó Bryan Turner en El Cuerpo y la sociedad. Exploraciones en teoría social en la década de los ochenta− son parte de la naturaleza, el trabajo debe comprenderel trabajo sobre nuestros cuerpos, los que son transformados en las prácticas culturales y políticas”.
CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity
Authors: Ramadan Yasmin H. , Gu Amanda , Ross Nicole , McEwan Sara A. , Barr Maureen M. , Firestein Bonnie L. , O’Hagan Robert 
Published: March 2021

AbstractMicrotubules (MTs) are cytoskeletal elements that provide structural support and act as roadways for intracellular transport in cells. MTs are also needed for neurons to extend and maintain long axons and dendrites that establish connectivity to transmit information through the nervous system. Therefore, in neurons, the ability to independently regulate cytoskeletal stability and MT-based transport in different cellular compartments is essential. Posttranslational modification of MTs is one mechanism by which neurons regulate the cytoskeleton. The carboxypeptidase CCP1 negatively regulates posttranslational polyglutamylation of MTs. In mammals, loss of CCP1, and the resulting hyperglutamylation of MTs, causes neurodegeneration. It has also long been known that CCP1 expression is activated by neuronal injury; however, whether CCP1 plays a neuroprotective role after injury is unknown. Using shRNA-mediated knock-down of CCP1 in embryonic rat spinal cord cultures, we demonstrate that CCP1 protects spinal cord neurons from excitotoxic death. Unexpectedly, excitotoxic injury reduced CCP1 expression in our system. We previously demonstrated that the CCP1 homolog inCaenorhabditis elegansis important for maintenance of neuronal cilia. Although cilia enhance neuronal survival in some contexts, it is not yet clear whether CCP1 maintains cilia in mammalian spinal cord neurons. We found that knock-down of CCP1 did not result in loss or shortening of cilia in cultured spinal cord neurons, suggesting that its effect on survival of excitotoxicity is independent of cilia. Our results support the idea that enzyme regulators of MT polyglutamylation might be therapeutically targeted to prevent excitotoxic death after spinal cord injuries.
A Heteromodal Word-Meaning Binding Site in the Visual Word Form Area under Top-Down Frontoparietal Control
Authors: Qin Lang , Lyu Bingjiang , Shu Su , Yin Yayan , Wang Xiongfei , Ge Jianqiao , Siok Wai-Ting , Gao Jia-Hong 
Published: March 2021

The integral capacity of human language together with semantic memory drives the linkage of words and their meaning, which theoretically is subject to cognitive control. However, it remains unknown whether, across different language modalities and input/output formats, there is a shared system in the human brain for word-meaning binding and how this system interacts with cognitive control. Here, we conducted a functional magnetic resonance imaging experiment based on a large cohort of subjects (50 females, 50 males) to comprehensively measure the brain responses evoked by semantic processing in spoken and written word comprehension and production tasks (listening, speaking, reading, and writing). We found that heteromodal word input and output tasks involved distributed brain regions within a frontal-parietal-temporal network and focally coactivated the anterior lateral visual word form area (VWFA), which is located in the basal occipitotemporal area. Directed connectivity analysis revealed that the VWFA was invariably under significant top-down modulation of the frontoparietal control network and interacts with regions related to attention and semantic representation. This study reveals that the VWFA is a key site subserving general semantic processes linking words and meaning, challenging the predominant emphasis on this area's specific role in reading or more general visual processes. Our findings also suggest that the dynamics between semantic memory and cognitive control mechanisms during word processing are largely independent of the modalities of input or output.SIGNIFICANCE STATEMENTBinding words and their meaning into a coherent whole during retrieval requires accessing semantic memory and cognitive control, allowing our thoughts to be expressed and comprehended through mind-external tokens in multiple modalities, such as written or spoken forms. However, it is still unknown whether multimodal language comprehension and production share a common word-meaning binding system in human brains and how this system is connected to a cognitive control mechanism. By systematically measuring brain activity evoked by spoken and written verbal input and output tasks tagging word-meaning binding processes, we demonstrate a general word-meaning binding site within the visual word form area (VWFA) and how this site is modulated by the frontal-parietal control network.
COVID-19 Infections Among Students and Staff in New York City Public Schools
Authors: Varma Jay K. , Thamkittikasem Jeff , Whittemore Katherine , Alexander Mariana , Stephens Daniel H. , Arslanian Kayla , Bray Jackie , Long Theodore G. 
Published: March 2021

BACKGROUND:
The 2019 novel coronavirus disease (COVID-19) pandemic led many jurisdictions to close in-person school instruction.

METHODS:
We collected data about COVID-19 cases associated with New York City (NYC) public schools from polymerase chain reaction testing performed in each school on a sample of asymptomatic students and staff and from routine reporting. We compared prevalence from testing done in schools to community prevalence estimates from statistical models. We compared cumulative incidence for school-associated cases to all cases reported to the city. School-based contacts were monitored to estimate the secondary attack rate and possible direction of transmission.

RESULTS:
To assess prevalence, we analyzed data from 234 132 persons tested for severe acute respiratory syndrome coronavirus 2 infection in 1594 NYC public schools during October 9 to December 18, 2020; 986 (0.4%) tested positive. COVID-19 prevalence in schools was similar to or less than estimates of prevalence in the community for all weeks. To assess cumulative incidence, we analyzed data for 2231 COVID-19 cases that occurred in students and staff compared with the 86 576 persons in NYC diagnosed with COVID-19 during the same period; the overall incidence was lower for persons in public schools compared with the general community. Of 36 423 school-based close contacts, 191 (0.5%) subsequently tested positive for COVID-19; the likely index case was an adult for 78.0% of secondary cases.

CONCLUSIONS:
We found that in-person learning in NYC public schools was not associated with increased prevalence or incidence overall of COVID-19 infection compared with the general community.
Pharmacological properties of edible Asparagus acutifolius and Asparagus officinalis collected from North Iraq and Turkey (Hatay)
Authors: Mohammed F.S. , Pehlivan M. , Sevindik E. , Akgul H. , Sevindik M. , Bozgeyik I. , Yumrutas O. 
Published: March 2021

AbstractIn this study, antioxidant, oxidant, antimicrobial, and antiproliferative activities of Asparagus acutifolius L. and Asparagus officinalis L., known for their nutritional properties, were determined. In this context, methanol (MeOH) and dichloromethane (DCM) extracts of plants were obtained. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined using Rel Assay kits. Antimicrobial activities of plant extracts were determined against the test microorganisms using the agar dilution method. Antiproliferative activity was tested on the lung cancer cell line A549. As a result of the studies, it has been determined that the plant species have high antioxidant potential. In addition, it was observed that the antifungal potentials of plant extracts are high. Antiproliferative activity was determined to be at high level in both plant species. As a result, it has been determined that A. acutifolius and A. officinalis have medical potential and can be used as natural agents in pharmacological designs.
Scientific Conference in Memory of Gyula Hajnóczi •
Authors: Krähling János 
Published: March 2021

The Department of History of Architecture and Monument Preservation of the Faculty of Architecture of the Budapest University of Technology and Economics and the Standing Committee on the History and Theory of Architecture and Monument Preservation of the Hungarian Academy of Sciences organized an online scientific conference on 12th November 2020, in memory of Gyula Hajnóczi, a recognized and highly respected professor of the department of architecture on the occasion of the 100th anniversary of his birth, entitled “Scientific Conference in Memory of Gyula Hajnóczi (Conference of Architectural Historians and Historic Building Researchers III)”. This paper intends to introduce this special issue of the journal with the summary of the conference.A Budapesti Műszaki és Gazdaságtudományi Egyetem Építészmérnöki Kar Építészettörténeti és Műemléki Tanszéke, a Magyar Tudományos Akadémia Építészettörténeti, Építészetelméleti és Műemléki Állandó Bizottsága részvételével Hajnóczi Gyula, a tanszék ismert, elismert és nagy tekintélyű egykori professzora tiszteletére, születésének 100. évfordulója alkalmából „Tudományos Konferencia Hajnóczi Gyula Emlékére (Építészettörténészek és Műemlékkutatók Konferenciája III.)” címmel 2020. november 12-én online tudományos konferenciát szervezett. Az írás röviden bevezeti e folyóirat különszámát.
A Novel Approach for Immediate Implant-Based Oral Rehabilitation in a Sjögren's Syndrome Patient Using Virtual Surgical and Prosthetic Planning
Authors: in 't Veld Matthijs , Schulten Engelbert A.J.M. , Neveling Ulf , Jan Jager Derk H. , Leusink Frank K.J. 
Published: March 2021

Patients with Sjögren syndrome (SS) experience difficulties in wearing conventional dentures. After removal of all teeth, the oral rehabilitation is challenging and time consuming using conventional treatment protocols. Although implant-retained overdentures are beneficial for this specific patient group, the average total oral rehabilitation time (TORT) usually takes at least 9 months and needs to be reduced to increase patients' quality of life (QoL). In this paper, we report on a new treatment concept for immediate implant-based oral rehabilitation in a 77-year-old patient with partial edentulous SS. Because of persistent pain, discomfort, and retention problems with the conventional prosthetic devices, full clearance of the remaining mandibular dentition and immediate oral rehabilitation with an implant-retained overdenture were suggested. The treatment protocol included virtual surgical planning (VSP), combining a guided bone reduction of the mandibular alveolar process, immediate dental implant placement, and restoration using a prefabricated bar and placement of the overdenture.
This method demands the use of ionizing 3D imaging optionally combined with an optical dental scan or a conventional impression. Furthermore, one needs to gain experience using VSP software.
This novel treatment concept for immediate implant-based oral rehabilitation using VSP proved to be feasible and safe in a patient with SS, resulting in a significantly reduced TORT and improved QoL. Further research is needed to what extent this treatment concept could be beneficial to other patient groups, such as patients with head and neck cancer.
Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier
Authors: Möller-Kerutt Annika , Rodriguez-Gatica Juan E. , Wacker Karin , Bhatia Rohan , Siebrasse Jan-Peter , Boon Nanda , Van Marck Veerle , Boor Peter , Kubitscheck Ulrich , Wijnholds Jan , Pavenstädt Hermann , Weide Thomas 
Published: March 2021

Significance Statement
Mutations in the Crumbs2 (CRB2) gene were recently identified as a cause of steroid-resistant nephrotic syndrome (SRNS), but it is unknown how Crumbs2 dysfunction damages the glomerular filtration barrier (GFB). Crumbs2 is a slit diaphragm protein, organized in clusters and able to interact with Nephrin. In mice, loss of Crumbs2 results in heavy proteinuria, accompanied by progressive podocyte foot process effacement, injury of renal cells, and inflammation, indicating that Crb2 is of similar relevance for the GFB as Nephrin. In vitro, CRB2 mutant proteins accumulate in the ER and trigger ER stress. Thus, in addition to loss of Crumbs2 at the slit diaphragm, ER stress induction could play a pivotal role in onset and disease progression in patients with SRNS.

Background
Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS).

Methods
To study the function of Crb2 at the renal filtration barrier, mice lacking Crb2 exclusively in podocytes were generated. Gene expression and histologic studies as well as transmission and scanning electron microscopy were used to analyze these Crb2
podKO knockout mice and their littermate controls. Furthermore, high-resolution expansion microscopy was used to investigate Crb2 distribution in murine glomeruli. For pull-down experiments, live cell imaging, and transcriptome analyses, cell lines were applied that inducibly express fluorescent protein–tagged CRB2 wild type and mutants.

Results

Crb2
podKO mice developed proteinuria directly after birth that preceded a prominent development of disordered and effaced foot processes, upregulation of renal injury and inflammatory markers, and glomerulosclerosis. Pull-down assays revealed an interaction of CRB2 with Nephrin, mediated by their extracellular domains. Expansion microscopy showed that in mice glomeruli, Crb2 and Nephrin are organized in adjacent clusters. SRNS-associated CRB2 protein variants and a mutant that lacks a putative conserved O-glycosylation site were not transported to the cell surface. Instead, mutants accumulated in the ER, showed altered glycosylation pattern, and triggered an ER stress response.

Conclusions
Crb2 is an essential component of the podocyte’s slit diaphragm, interacting with Nephrin. Loss of slit diaphragm targeting and increasing ER stress are pivotal factors for onset and progression of CRB2-related SRNS.
Development and validation of a ferroptosis-related lncRNAs prognosis signature in colon cancer
Authors: Cai Hua-jun , Zhuang Zhi-cheng , Wu Yong , Zhang Yi-yi , Liu Xing , Zhuang Jin-fu , Yang Yuan-feng , Gao Yuan , Chen Bin , Guan Guo-xian 
Published: March 2021

Ferroptosis is a form of iron-dependent programmed cell death. Regulate ferroptosis in tumor cells is a novel treatment modality. The present study aimed to investigate ferroptosis-related long non-coding RNAs (lncRNAs) and construct a prognostic model for colon adenocarcinoma (COAD). RNA- sequencing data and ferroptosis-related genes were obtained from The Cancer Genome Atlas database and FerrDb database. COAD patients were randomly assigned to training- and validation groups. The Least Absolute Shrinkage and Selection Operator regression and Cox regression model were used to determine and develop a predictive model. The model was corroborated using the validation group and the entire group. In total, 259 ferroptosis-related genes and 905 ferroptosis-related LncRNAs were obtained. Cox model revealed and constructed seven ferroptosis-related LncRNAs signature (LINC01503, AC004687.1, AC010973.2, AP001189.3, ARRDC1-AS1, OIP5-AS1, and NCK1-DT). Patients were assigned into two groups according to the median risk score. Kaplan–Meier survival curves showed that overall survival between high- and low-risk groups was statistically significant (P<0.01). Cox multivariate analysis seven ferroptosis-related LncRNAs signature was an independent risk factor for COAD outcomes (P<0.05). The relationship between seven ferroptosis-related LncRNAs and clinicopathological features was also examined. The principal component analysis showed a difference between high- and low-risk groups intuitively. With the aid of gene set enrichment analysis, the underlying mechanisms of seven ferroptosis-related LncRNAs were uncovered, including the MAPK signaling pathway, mTOR signaling pathway, and glutathione metabolism pathway. Finally, we established and validated seven ferroptosis-related lncRNAs signature for COAD patients to predict survival. These results may provide meaningful targets for future study.