bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the Stability of COVID‐19 Serological Assay through Metal–Organic Framework Encapsulation
Authors: Wang Yixuan , Wang Zheyu , Gupta Prashant , Morrissey Jeremiah J. , Naik Rajesh R. , Singamaneni Srikanth 
Published: July 2021

AbstractEnzyme‐linked immunosorbent assay is widely utilized in serologic assays, including COVID‐19, for the detection and quantification of antibodies against SARS‐CoV‐2. However, due to the limited stability of the diagnostic reagents (e.g., antigens serving as biorecognition elements) and biospecimens, temperature‐controlled storage and handling conditions are critical. This limitation among others makes biodiagnostics in resource‐limited settings, where refrigeration and electricity are inaccessible or unreliable, particularly challenging. In this work, metal–organic framework encapsulation is demonstrated as a simple and effective method to preserve the conformational epitopes of antigens immobilized on microtiter plate under non‐refrigerated storage conditions. It is demonstrated that in situ growth of zeolitic imidazolate framework‐90 (ZIF‐90) renders excellent stability to surface‐bound SARS‐CoV‐2 antigens, thereby maintaining the assay performance under elevated temperature (40 °C) for up to 4 weeks. As a complementary method, the preservation of plasma samples from COVID‐19 patients using ZIF‐90 encapsulation is also demonstrated. The energy‐efficient approach demonstrated here will not only alleviate the financial burden associated with cold‐chain transportation, but also improve the disease surveillance in resource‐limited settings with more reliable clinical data.
Pushing the Limits of Flexibility and Stretchability of Solar Cells: A Review
Authors: Dauzon Emilie , Sallenave Xavier , Plesse Cedric , Goubard Fabrice , Amassian Aram , Anthopoulos Thomas D. 
Published: July 2021

AbstractEmerging forms of soft, flexible, and stretchable electronics promise to revolutionize the electronics industries of the future offering radically new products that combine multiple functionalities, including power generation, with arbitrary form factor. For example, skin‐like electronics promise to transform the human‐machine‐interface, but the softness of the skin is incompatible with traditional electronic components. To address this issue, new strategies toward soft and wearable electronic systems are currently being pursued, which also include stretchable photovoltaics as self‐powering systems for use in autonomous and stretchable electronics of the future. Here recent developments in the field of stretchable photovoltaics are reviewed and their potential for various emerging applications are examined. Emphasis is placed on the different strategies to induce stretchability including extrinsic and intrinsic approaches. In the former case, engineering and patterning of the materials and devices are key elements while intrinsically stretchable systems rely on mechanically compliant materials such as elastomers and organic conjugated polymers. The result is a review article that provides a comprehensive summary of the progress to date in the field of stretchable solar cells from the nanoscale to macroscopic functional devices. The article is concluded by discussing the emerging trends and future developments.
Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury
Authors: Yuan Taoyang , Shao Yu , Zhou Xu , Liu Qian , Zhu Zhichao , Zhou Bini , Dong Yuanchen , Stephanopoulos Nicholas , Gui Songbai , Yan Hao , Liu Dongsheng 
Published: July 2021

AbstractRegeneration after severe spinal cord injury cannot occur naturally in mammals. Transplanting stem cells to the injury site is a highly promising method, but it faces many challenges because it relies heavily on the microenvironment provided by both the lesion site and delivery material. Although mechanical properties, biocompatibility, and biodegradability of delivery materials have been extensively explored, their permeability has rarely been recognized. Here, a DNA hydrogel is designed with extremely high permeability to repair a 2 mm spinal cord gap in Sprague–Dawley rats. The rats recover basic hindlimb function with detectable motor‐evoked potentials, and a renascent neural network is formed via the proliferation and differentiation of both implanted and endogenous stem cells. The signal at the lesion area is conveyed by, on average, 15 newly formed synapses. This hydrogel system offers great potential in clinical trials. Further, it should be easily adaptable to other tissue regeneration applications.
Label‐Free Quantitative Analysis of Coacervates via 3D Phase Imaging
Authors: Hong Yuri , Dao Khoi Phuong , Kim Taehyun , Lee Sumin , Shin Yongdae , Park YongKeun , Hwang Dong Soo 
Published: July 2021

AbstractCoacervation is considered as a ubiquitous mechanism for assembling biomolecular materials outside cells and organizing membraneless organelles inside cells. Despite the importance of mapping binodals to understand the driving forces and thermodynamics of coacervate, quantifying protein concentration within a droplet is significantly challenging owing to its dynamic and viscous nature. A direct imaging‐based method is presented to quantify coacervate using real‐time 3D quantitative phase imaging. The proposed method utilizes the measurements of the refractive index tomograms of individual coacervates and retrieves the protein concentration and volume of individual protein droplets exploiting light‐scattering analysis. The retrievals of accurate protein concentrations are demonstrated in droplets, whereas conventional fluorescence‐based techniques present underestimations. With its simple, direct, real‐time, and quantitative analysis capability, the present method can be utilized in various protein analyses and quantifications for the study of coacervation both in vitro and in vivo.
Sustainable Production of Benzylamines from Lignin
Authors: Zhang Bo , Guo Tenglong , Liu Yuxuan , Kühn Fritz E. , Wang Chao , Zhao Zongbao K. , Xiao Jianliang , Li Changzhi , Zhang Tao 
Published: July 2021

AbstractCatalytic conversion of lignin into heteroatom functionalized chemicals is of great importance to bring the biorefinery concept into reality. Herein, a new strategy was designed for direct transformation of lignin β‐O‐4 model compounds into benzylamines and phenols in moderate to excellent yields in the presence of organic amines. The transformation involves dehydrogenation of Cα−OH, hydrogenolysis of the Cβ−O bond and reductive amination in the presence of Pd/C catalyst. Experimental data suggest that the dehydrogenation reaction proceeds over the other two reactions and secondary amines serve as both reducing agents and amine sources in the transformation. Moreover, the concept of “lignin to benzylamines” was demonstrated by a two‐step process. This work represents a first example of synthesis of benzylamines from lignin, thus providing a new opportunity for the sustainable synthesis of benzylamines from renewable biomass, and expanding the products pool of biomass conversion to meet future biorefinery demands.
Resolution of Lithium Deposition versus Intercalation of Graphite Anodes in Lithium Ion Batteries: An In Situ Electron Paramagnetic Resonance Study
Authors: Wang Bin , Le Fevre Lewis W. , Brookfield Adam , McInnes Eric J. L. , Dryfe Robert A. W. 
Published: July 2021

AbstractIn situ electrochemical electron paramagnetic resonance (EPR) spectroscopy is used to understand the mixed lithiation/deposition behavior on graphite anodes during the charging process. The conductivity, degree of lithiation, and the deposition process of the graphite are reflected by the EPR spectroscopic quality factor, the spin density, and the EPR spectral change, respectively. Classical over‐charging (normally associated with potentials ≤0 V vs. Li+/Li) are not required for Li metal deposition onto the graphite anode: Li deposition initiates at ca. +0.04 V (vs. Li+/Li) when the scan rate is lowered to 0.04 mV s−1. The inhibition of Li deposition by vinylene carbonate (VC) additive is highlighted by the EPR results during cycling, attributed to a more mechanically flexible and polymeric SEI layer with higher ionic conductivity. A safe cut‐off potential limit of +0.05 V for the anode is suggested for high rate cycling, confirmed by the EPR response over prolonged cycling.
Hypoxia‐Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild‐Photothermal Therapy
Authors: Li Xueqing , Pan Yongchun , Chen Chao , Gao Yanfeng , Liu Xinli , Yang Kaiyong , Luan Xiaowei , Zhou Dongtao , Zeng Fei , Han Xin , Song Yujun 
Published: July 2021

AbstractNear‐infrared (NIR)‐light‐triggered photothermal therapy (PTT) is usually associated with undesirable damage to healthy organs nearby due to the high temperatures (>50 °C) available for tumor ablation. Low‐temperature PTT would therefore have tremendous value for clinical application. Here, we construct a hypoxia‐responsive gold nanorods (AuNRs)‐based nanocomposite of CRISPR‐Cas9 for mild‐photothermal therapy via tumor‐targeted gene editing. AuNRs are modified with azobenzene‐4,4′‐dicarboxylic acid (p‐AZO) to achieve on‐demand release of CRISPR‐Cas9 using hypoxia‐responsive azo bonds. In the hypoxic tumor microenvironment, the azo groups of the hypoxia‐activated CRISPR‐Cas9 nanosystem based on gold nanorods (APACPs) are selectively reduced by the overexpression of reductases, leading to the release of Cas9 and subsequent gene editing. Owing to the knockout of HSP90α for reducing the thermal resistance of cancer cells, highly effective tumor ablation both in vitro and in vivo was achieved with APACPs under mild PTT.
Modulating Chalcogen Bonding and Halogen Bonding Sigma‐Hole Donor Atom Potency and Selectivity for Halide Anion Recognition
Authors: Docker Andrew , Guthrie Charles H. , Kuhn Heike , Beer Paul D. 
Published: July 2021

AbstractA series of acyclic anion receptors containing chalcogen bond (ChB) and halogen bond (XB) donors integrated into a neutral 3,5‐bis‐triazole pyridine scaffold are described, in which systematic variation of the electronic‐withdrawing nature of the aryl substituents reveal a dramatic modulation in sigma‐hole donor atom potency for anion recognition. Incorporation of strongly electron‐withdrawing perfluorophenyl units appended to the triazole heterocycle telluro‐ or iodo‐ donor atoms, or directly linked to the tellurium donor atom dramatically enhances the anion binding potency of the sigma‐hole receptors, most notably for the ChB and XB receptors displaying over thirty‐fold and eight‐fold increase in chloride anion affinity, respectively, relative to unfluorinated analogues. Linear free energy relationships for a series of ChB based receptors reveal the halide anion recognition behaviour of the tellurium donor is highly sensitive to local electronic environments. This is especially the case for those directly appended to the Te centre (3⋅ChB), where a remarkable enhancement of strength of binding and selectivity for the lighter halides is observed as the electron‐withdrawing ability of the Te‐bonded aryl group increases, highlighting the exciting opportunity to fine‐tune anion affinity and selectivity in ChB‐based receptor systems.
Synthesis of poly (vinylpyrrolidone)/Fe3O4@SiO2 nanoporous catalyst by γ‐rays and evaluation their sono‐photo‐Fenton degradation of toluidine blue under magnetic field
Authors: Ghobashy Mohamed Mohamady , Elbarbary Ahmed M. , Hegazy Dalia E. 
Published: July 2021

AbstractNanoporous of poly (vinylpyrrolidone)/Fe3O4@SiO2 has been synthesized using ultrasonic‐assisted‐gamma irradiation technique and characterized by transmission electron microscopy (TEM), scanning electron microscope (SEM)/energy‐dispersive spectroscopy (EDX), Fourier transform infrared (FTIR), X‐ray diffraction (XRD), Vibrating Sample Magnetometer (VSM), and Brunauer–Emmett–Teller (BET). The efficiency evaluation of PVP/Fe3O4@SiO2 nanoporous catalyst for degradation of toluidine blue (TB) by sono‐photo‐Fenton (US/UV/FE) processes has been investigated using modified reactor under the influence of magnetic field (MF) 250 Gauss. PVP molecules prevent ions leaching and render Fe3O4@SiO2 nanoparticles to bind with pollutant molecules. Comparative effect of sonication assists on photo‐Fenton processes has been studied. The TB degradation was examined at different pHs and H2O2 concentration. After 60 min, the photo‐catalytic degradation rate of TB is attained to optimum value (83%) at pH 4. The photo‐Fenton catalytic degradation rate of TB decreased (36.39%, 31.84%, and 23.92%) within (0.5, 1.0, and 1.5 M) of H2O2, respectively. The degradation of TB by sono‐photo‐Fenton process was 76.55 and 95.3% after 60 and 10 min in absence and presence of MF, respectively. Negligible amounts of Fe leaching from PVP/Fe3O4@SiO2 confirm high stability in oxidation systems. BET surface area and pore volume of PVP/Fe3O4@SiO2 were 43.50 m2 g−1 and 0.1798 cm3 g−1, respectively, with pore size distribution of 16.53 nm indicating their nanoporosity structure. Herein, the novelty is evaluated through the effect of MF and ultrasound‐assisted photo‐Fenton system for TB degradation using novel PVP/Fe3O4@SiO2 nanoporous catalyst that easily recovered from the reaction solution by external magnet. The PVP/Fe3O4@SiO2/US/UV/FE/MF hybrid system can be introduced as a successful advanced treatment process for degradation of dyes from wastewater with high degradation efficiency in short time.
Mechanical behavior of electrophoretically modified CFRP composites at elevated temperatures: An assessment of the influence of graphene carboxyl bath concentration
Authors: Gangineni Pavan Kumar , Patnaik Satyaroop , Prusty Rajesh Kumar , Ray Bankim Chandra 
Published: July 2021

AbstractThe study aims at investigating the mechanical behavior of carbon fiber reinforced polymer (CFRP) composites modified with graphene carboxyl at elevated temperature (ET‐110°C) and understanding the effect of electrophoretic deposition bath concentration (0.5 g/L, 1.0 g/L, and 1.5 g/L) on their mechanical behavior at ET. The 1.5 g/L composite has revealed a maximum improvement in energy absorbed before failure of 33.25% at RT and 22.54% at ET for flexural testing and ∼35% at RT for short beam shear testing, over neat CFRP composite. The modified composites have shown an improved flexural strain to failure at both RT and ET, with 1.5 g/L composite exhibiting maximum enhancement of 12.41% at RT and 26.52% at ET over neat composite. However, at ET, modified composites exhibited lower flexural strength and interlaminar shear strength values in comparison to that of neat. Viscoelastic behavior of all composites was studied to understand bath concentration's effect on thermal behavior via dynamic mechanical thermal analysis. Differential scanning calorimetry was employed for governing the glass transition temperature of composites. Fractography of tested samples (both ET and RT) was performed utilizing a scanning electron microscope to determine the prominent failure mode.
Do Pleistocene rock paintings depict Sulawesi warty pigs (Sus celebensis) with a domestication character?
Authors: BRUMM ADAM , OKTAVIANA ADHI AGUS , BURHAN BASRAN , HAKIM BUDIANTO , LEBE RUSTAN , RIRIMASSE MARLON , SULISTYARTO PRIYATNO HADI , MACDONALD ALASTAIR A. , AUBERT MAXIME 
Published: July 2021

AbstractThe Indonesian island of Sulawesi harbours numerous early rock paintings of the endemic Sulawesi warty pig (Sus celebensis). SeveralS. celebensisimages, including one dated to at least 45,500 years ago (ka), portray these suids with an anatomical character not observed in the living species: a pair of teat‐like protuberances in the neck area. This feature seems to be most consistent morphologically with neck “wattles”, cutaneous appendages only manifested in modern domestic swine (Sus scrofa) and some other domesticated ungulates (e.g. goats). The notion that the trait portrayed by the Late Pleistocene artists is a domestication character is clearly contentious. We therefore consider: (1) whether we have misidentified the trait – a common problem in rock art analysis; (2) whether wattles are a genuine domestication trait; and (3) if so, whether the notion that Pleistocene people domesticatedS. celebensisis plausible. A clear resolution to all of these problems evades us; however, our investigation of this anomaly in the ancient rock art poses important questions about the nature and complexity of early human–pig relations in this island.
Preparation and characterization of poly (lactic‐co‐glycolic acid) nanofibers containing simvastatin coated with hyaluronic acid for using in periodontal tissue engineering
Authors: Malekpour Zahra , Akbari Vajihe , Varshosaz Jaleh , Taheri Azade 
Published: July 2021

AbstractPeriodontal diseases can lead to soft tissue defects. Tissue engineering can provide functional replacements for damaged tissues. Recently, electrospun nanofibers have attracted great interest for tissue engineering and drug delivery applications. This has been revealed that statins exhibit positive impacts on the proliferation and regeneration of periodontal tissues. Electrospun simvastatin loaded poly (lactic‐co‐glycolic acid) (SIM‐PLGA‐NF) were prepared using electrospinning technique. Optimal conditions for preparation of SIM‐PLGA‐NF (PLGA concentration of 30 wt%, voltage of 15 kV, and flow rate of 1.5 ml h−1) were identified using a 23factorial design. The optimized SIM‐PLGA‐NFs (diameter of 640.2 ± 32.5 nm and simvastatin entrapment efficacy of 99.6 ± 1.5%) were surface modified with 1% w/v hyaluronic acid solution (1%HA‐ SIM‐PLGA‐NF) to improve their compatibility with fibroblasts and potential application as a periodontal tissue engineering scaffold. HA‐SIM‐PLGA NFs were analyzed using SEM, FTIR, and XRD. 1%HA‐SIM‐PLGA‐NF had uniform, bead‐free and interwoven morphology, which is similar to the extracellular matrix. The mechanical performance of SIM‐PLGA‐NFs and release profile of simvastatin from these nanofibers have been also greatly improved after coating with HA. In vitro cellular tests showed that the proliferation, adhesion, and differentiation of fibroblast cells positively enhanced on the surface of 1%HA‐ SIM‐PLGA‐NF. These results demonstrate the potential application of 1%HA‐SIM‐PLGA‐NFs as a scaffold for periodontal tissue engineering.
Balancing web personalization and consumer privacy concerns: Mechanisms of consumer trust and reactance
Authors: Chen Xinyu , Sun Jian , Liu Hongyan 
Published: July 2021

AbstractInformation technology and e‐commerce enable websites to provide personalized services based on consumer information, thereby providing convenience to consumers. However, the collection and use of consumer information may trigger concerns regarding privacy invasion. Grounded in exchange theory, the current study constructs a framework that links web personalization to consumer decisions (i.e., website loyalty and purchase intention) through consumer trust and reactance. The study also uses reactance theory as the theoretical basis to examine the moderating role of privacy concerns. An online survey was used to assess the effect of web personalization on consumer loyalty. The results show that consumers' privacy concerns negatively moderate the relationship between web personalization and website loyalty, and the influencing mechanism differs according to the levels of privacy concerns. More specifically, when consumers are less concerned about privacy, web personalization strengthens consumer trust to enhance loyalty. When consumers are more concerned about privacy, web personalization affects their loyalty through psychological reactance. The study findings show that although personalized services provide convenience to consumers, websites should carefully consider consumers' privacy issues. The trade‐off between web personalization and privacy concerns is necessary for a website's success.
Successful treatment of acute promyelocytic leukemia in a patient undergoing hemodialysis with arsenic trioxide
Authors: Hashimoto Akiko , Tanaka Yasuhiro , Shinzato Isaku 
Published: July 2021

AbstractA man undergoing hemodialysis was diagnosed with acute promyelocytic leukemia (APL). He received arsenic trioxide as a single agent and achieved complete molecular remission without severe adverse events. Arsenic trioxide can be used safely and effectively for patients with APL under hemodialysis.
Intraosseous clear cell mucoepidermoid carcinoma in the maxilla: A case report and review of literature
Authors: Harada Fumiya , Abiko Yoshihiro , Khurelchuluun Ariuntsetseg , Yoshida Koki , Takeda Shigehiro , Nakayama Eiji , Shimo Tsuyoshi , Nagayasu Hiroki 
Published: July 2021

AbstractWe reported an extremely rare case regarding intraosseous clear cell variant of mucoepidermoid carcinoma in maxilla.
Infectious‐mononucleosis‐like exanthema associated with COVID‐19 in a child
Authors: Ferjani Meryam , Ben Slimane Malek , Sayari Taha , Hammi Yosra , Litaiem Noureddine , Naija Ouns , Zeglaoui Faten , Gargah Tahar 
Published: July 2021

AbstractCutaneous manifestations of childhood COVID‐19 differ from those of adults. Maculopapular rash is not specific and could be mistaken with other viral exanthema. A nasopharyngeal swab is strongly recommended to confirm the possible COVID‐19 diagnosis.
A VPS13B mutation in Cohen syndrome presented with petechiae: An unusual presentation
Authors: Razavi Alireza , Jafarpour Hamed , Khosravi Mohammad reza , Abbasi Ghazal , Dabbaghzadeh Abbas 
Published: July 2021

AbstractCohen syndrome (CS) is a rare autosomal recessive disorder. CS includes a range of clinical symptoms including retinal dystrophy and myopia. The new VPS13B mutation could cause CS‐induced neutropenia and petechiae in patients with CS.
Craniolacunia in A neonate; A clinical and CT scan illustrative case report
Authors: Edzie Emmanuel Kobina Mesi , Dzefi‐Tettey Klenam , Gorleku Philip Narteh , Agyen‐Mensah Kwasi , Kusodzi Henry , Quarshie Frank , Asemah Abdul Raman 
Published: July 2021

AbstractNeural tube defects can be accurately diagnosed prenatally. Every effort must be made to get this and its associations with Craniolacunia right, especially in low‐resource settings. This case highlights the importance of three‐dimensional CT in diagnosing neonatal skull abnormalities.
Blowing off steam—Identifying bowel perforation after routine colonoscopy
Authors: Hussain Murtaza S. , Deliwala Smit S. , Gupta Rohit , Berrou Mohammed 
Published: July 2021

AbstractColonoscopy is an effective procedure for colorectal cancer (CRC) screening. Perforation is a rare yet the most severe complication, identified by landmarks—double dolphin, triangle, or double‐wall sign signifying air and intracolonic contents leaking into the peritoneal space. Prompt recognition and surgical intervention are imperative to avoid high mortality.
Multifocal bone tuberculosis simulating metastasis
Authors: Chabchoub Imen , Ben Salah Raida , Feki Wien , Mnif Zeineb , Bahloul Zouhir 
Published: July 2021

AbstractMultiple skeletal tuberculosis can be the first sign of tuberculosis. In such cases, physicians should consider tuberculosis diagnosis and take biopsies for anatomopathological evidence to make the correct diagnosis.