bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of endocrine profile and five-year survival of cardiac resynchronization therapy male responders residing in conditions of the Far North and south of Tyumen region
Authors: Enina T. N. , Petelina T. I. , Shirokov N. E. , Repina I. A. , Gapon L. I. 
Published: December 2024

Aim. To evaluate endocrine profile, biomarkers of heart failure, 5-year survival of cardiac resynchronization therapy (CRT) male responders living in the Far North (FN) and the south of Tyumen region (sTr).Methods. Fifty-six CRT male responders (with decrease of left ventricular end-systolic volume >15% in November 2020) under the age of 65 (55.0±7.8 years old) were divided into 2 groups: 1(n=23) - FN patients; 2 (n=33) - sTr. Echocardiography (Echo), thyroid-stimulating hormone (TSH), triiodothyronine (fT3), thyroxine (fT4), parathyroid hormone (PTH), cortisol (CORT), testosterone (TES), estradiol (E2), dihydroepiandrosterone sulfate (DHEAS), progesterone (PGN), adrenaline (Adr), norepinephrine (NAdr), interleukins (IL) 6, 10, tumor necrosis factor (TNF-α), C-reactive protein (CRP), NT-proBNP, myeloperoxidase (MPO), matrix metalloproteinase (MMP-9 ), tissue inhibitor of metalloproteinases (TIMP-1) were assessed. Relationship of hormones with Echo, biomarkers was evaluated by Spearman method, 5-year survival - by Kaplan-Meier method, and association of lastmentioned with studied factors - by Cox regression.Results. Radiofrequency ablation of atrioventricular junction (RFA AVJ) were differed in groups (47.8 vs 21.2%; p=0.036). At the initial stage, in group 1, right ventricle, Adr, TNF-α, CRP, TIMP-1, CORT, TSH, fT4 were greater, fT3/fT4 was lower. In groups, reverse cardiac remodeling was revealed in dynamics; decrease of TIMP-1, PGN in Gr1; decrease of NT-proBNP, TIMP-1, MPO, PGN, increase of TES, E2, TNF-α in Gr2,. Positive associations of TSH, PTH and negative - DHEAS with Echo; positive connections between PGN, CORT and MMP-9; TES with NAdr; E2 with IL-10 were registered. Five-year survival rate was 80.7% vs 83.4% (Log Rank test=0.724), associated with IL-6 level in northerners.Conclusion. Multihormonal imbalance, manifested by greater levels of CORT, TSH, fT4, lower values of fT3/fT4, accompanied by sympatho-adrenal, immune activation, fibroformation imbalance, higher power of RFA AVJ, indicates greater severity of heart failure, tension of adaptive mechanisms in CRT male responders of FN. CRT modulating effects in groups contributed to comparable 5-year survival associated with level of IL-6 in northerners.
Predictors of early recurrence of atrial tachyarrhythmias after catheter ablation of atrial fibrillation
Authors: Moskovskih T. V. , Smorgon A. V. , Usenkov S. Yu. , Archakov E. A. , Sitkova E. S. , Batalov R. E. , Sazonova S. I. 
Published: December 2024

Aim. Search for predictors of early recurrence of atrial tachyarrhythmias after radiofrequency ablation (RFA) of atrial fibrillation (AF).Methods. The study included 57 subjects with persistent (n = 17; 30%) and paroxysmal (n = 40; 70%) forms of AF, admitted for the RFA. All patients underwent transthoracic echocardiography, assessment of deformation of both atria using 2D Strain, computed tomography (CT) with 3D reconstruction of the left atrium (LA). Intraoperatively, high-density voltage mapping of LA was performed before RF pulmonary vein isolation. All patients underwent follow-up after 3 months.Results. Recurrence of atrial tachyarrhythmia after 3 months was recorded in 17.5% of patients. High prevalence of low-amplitude activity zones in the LA and persistent AF were the strongest predictors. The LA reservoir function below 21.7%, the conduction function below 15.7%, the LA stiffness index above 0.314 relative units, the LA volume with the appendage above 121.7 ml, and the LA vertical size according to CT data above 65.5 mm statistically significantly predicted early recurrences of atrial tachyarrhythmias with high sensitivity and specificity.Conclusion. The decreased LA deformation in the reservoir and conductor phase, increased LA stiffness index, the prevalence of low-amplitude activity zones, vertical size and volume of the LA with an auricle according to CT data and persistent AF are significant predictors of early relapses after interventional treatment of AF.
Endocardial lead implantation in patients with vein access obstruction
Authors: Aivazian S. A. , Sorokin I. N. , Palagina A. A. , Seregin A. A. , Shamatolskiy A. N. 
Published: December 2024

Aim. To present the experience of lead implantation in patients with cardiac implantable electronic devices (CIED) and access veins stenoses/occlusions, evaluate the effectiveness and safety of different methods and propose a decision-making algorithm for the method of new lead implantation in such patients.Methods. The study includes 31 patients with CIED and access veins obstruction, which required implantation of new leads. Leads were implanted after recanalization of the veins with hydrophilic wires through long introducers, or after transvenous lead extraction (TLE) using TightRail sheath.Results. Recanalization of veins using guidewires followed by lead implantation through a long introducer was performed in 24 patients, in 9 of them, after recanalization as the second step during the same procedure, TLE was performed. TLE without preliminary recanalization with guidewire was performed in 5 patients. In two patients, leads were implanted after vein puncture medial to the occlusion. Successful new leads implantation was performed in all patients. Decision making algorithm for the method of leads implantation through obstruction veins in various clinical situations is proposed.Conclusions. Recanalization of occluded veins with guidewire and TLE in patients with CIED are effective methods for providing ipsilateral access for lead implantation through obstructed veins. The safety of TLE in patients with access vein obstruction requires further study.
К ЮБИЛЕЮ ВИДНОГО МАРИЙСКОГО УЧЕНОГО (ФЕДОРУ ИВАНОВИЧУ ГОРДЕЕВУ - 95)
Authors: Максимов Валерий Николаевич 
Published: December 2024

Статья посвящена исследователю в области марийского и финно-угорского языкознания, кандидату филологических наук, профессору Марийского государственного педагогического института им. Н. К. Крупской Федору Ивановичу Гордееву. Охарактеризована его научная и просветительская деятельность, описан вклад языковеда в развитие родного языка. Область научных интересов Ф. И. Гордеева - марийское и финно-угорское языкознание, междисциплинарные аспекты языкознания, история родного языка, ономастика, терминология, лексикография.
The article is devoted to Gordeev Fedor, the researcher, Candidate of Philological Sciences, Professor of the Mari State Pedagogical Institute named after N.K. Krupskaya. His scientific and educational activities are characterized, and F. Gordeev’s contribution to the development of his native language is described. The area of scientific interests of Fedor Gordeev is Mari and Finno-Ugric linguistics, interdisciplinary aspects of linguistics, history of the native language, onomastics, terminology and lexicography.
Etiology, clinical manifestations and prevention of perianal infection in patients with hematological malignancies
Authors: Shtyrkova S. V. , Сhabaeva Y. A. , Kulikov S. M. , Danishian K. I. , Parovichnikova E. N. 
Published: December 2024

Introduction. Perianal infection (PI) in patients with hematological malignancies is characterized by a wide spectrum of pathogens and a variety of clinical manifestations and mechanisms of development of the infectious process.Aim: to study the pathogenetic mechanisms of PI development in patients with hematological malignancies and to develop prevention tactics.Materials and methods. The prospective study included 132 patients with hematological malignancies who had episodes of PI. The infectious process in the pararectal fi ber was registered based on the data of clinical examination or magnetic resonance imaging. Sources of infection and microbiologic results were studied.Results: Two main mechanisms of PI development were revealed, the frequency of which was statistically significantly different depending on the presence of neutropenia (p < 0.0001, odds ratio (OR) = 24.42 (confidence interval (CI) 95% [9.82–60.74]). In PI episodes that developed against the background of neutropenia, the predominant mechanism of infection was the penetration of microorganisms through broken tissue barriers (75 %): anal fissures were the entry gate of infection in 62.9 % of episodes; perianal ulcers and skin erosions — in 12.1 %. The alternative route of infection (cryptogladular mechanism) was registered in the majority of patients without neutropenia (66.7 %) and was represented by the involvement of crypts of the anal canal (28.6 %) or the presence of pararectal fistulas (38.1 %). Clinical manifestations of PI were associated with leukocyte count (p < 0.0001) and mechanism of infection (p < 0.0001). The median leukocyte count in patients with abscesses (2.12×109 /L) was statistically significantly higher than in infiltrates (0.57×109 /L) and necrosis (0.74×109 /L). The main source of infection in infiltrates was anal fissures (70.4 %), while in abscesses the main sources of infection were crypts of the anal canal (39 %) and pararectal fistulas (36 %). The main causative agents of PI were Gram-negative bacteria (Escherichia coli (43 %), Klebsiella spp. (15 %), Pseudomonas aeruginosa (4.4 %)), and Enterococci (12.5 %). P. aeruginosa was isolated more often in necrosis (22 %) than in other clinical forms of PI (3–5 %) (p = 0.0033), while the frequency of detection of other bacteria was independent of the clinical manifestations of PI. PI was a microbiologically proven source of sepsis in 9.5 % of PI episodes. The probability of PI-associated bloodstream infections was highest at 5 days and was significantly higher in patients with neutropenia (10 % vs 2 %) (p = 0.0044).Conclusion: Different mechanisms of pararectal cell infection should be taken into account when forming a strategy for the prevention of PI.
Treatment of secondary hemophagocytic syndrome
Authors: Potapenko V. G. , Antonov М. М. , Antipova A. S. , Avdoshina D. D. , Gaidukova I. Z. , Goloshchapov O. V. , Dulaeva E. N. , Zabutova Yu. V. , Karyagina E. V. , Kotova N. A. , Kozyro V. V. , Kulibaba T. G. , Lapin S. V. , Meshhaninova S. G. , Molchan A. A. , Palvuchenko E. S. , Pervakova M. Yu. , Petrova M. S. , Potikhonova N. A. , Ryabchikova V. V. , Surkova E. A. , Мedvedeva N. V. , Mironova O. P. , Nebeliczkaya O. V. , Nesterov Yu. A. , Samorodova I. A. , Serkov A. V. , Skorokhod I. A. , Skoryukova K. V. , Skorobogatova N. V. , Fedunjak I. P. , Chernookaya N. Yu. , Chaginskaya D. A. , Noviczkij A. V. 
Published: December 2024

Introduction. Hemophagocytic syndrome (HPS) is a reaction of severe, excessive, but ineffective inflammation. HPS is divided into primary or as a complication of a different causes — secondary HPS (sHPS).Aim: to analyze the effi cacy of different treatments in sHPS patients.Materials and methods. For the retrospective analysis, the medical documentation of patients who were treated in the period from June 2009 to January 2023 was used. The H-Score and HLH-2004 criteria were used to verify sHPS. The results of clinical blood analysis and biochemical tests are presented. The survival was analyzed within two weeks after the verification of sHPS. The main treatment options for sHPS were etoposide, glucocorticosteroids (GCSs), anticancer therapy and intravenous immunoglobulin.Results. The study included data from 130 patients, median age 56 years (18–90); 70 females and 60 males with sHPS. All patients received treatment with a drug change in cases of inefficiency: a total of 186 episodes. A stable response was achieved in 74 (56.9 %) patients. The median survival in patients without a response was 2 days. If the therapy was effective, the median survival was not reached. Positive dynamics were observed during the first day after the start of effective treatment, however, a few patients had transient worsening of some markers. The main factor in the negative prognosis was the degree of multiple organ failure during sHPS verification. In the group of patients with autoimmune diseases, GCSs were the most effective, with a response reached in 75 % of cases. For patients with resistance, as well as in patients with Epstein—Barr virus infection and blood malignancy, etoposide proved to be effective in 65.7 % of cases.Conclusion. sHPS was accompanied by an increase in pancytopenia, cytolytic, cholestatic syndromes, hypocoagulation, azotemia, hypertriglyceridemia and excessive hyperferritinemia. After the initiation of effective therapy, persistent clinical and laboratory responses developed during the first day. Therapy by GCSs was effective in most patients with autoimmune diseases associated with sHPS. With other forms of sHPS in the studied group, etoposide had the most pronounced effect.
The role of oxidative stress in bone tissue in the pathogenesis of osteopenia in patients with chronic lymphocytic leukemia
Authors: Osikov M. V. , Korobkin E. A. , Korobkin A. V. 
Published: December 2024

Introduction. A decrease in bone mineral density (BMD), the development of osteopenia and osteoporosis is observed in patients with chronic lymphocytic leukemia (CLL). Patients with CLL are at a higher risk of developing fractures due to osteoporosis compared to healthy age-matched individuals. The pathogenesis of the osteodestructive process in CLL has been poorly studied and may be associated with excessive generation of reactive oxygen species and/or inhibition of antioxidant defense.Aim: to investigate the relationship between indicators of oxidative stress in bone tissue and indicators of osteopenia in patients with CLL.Materials and methods. The study included 48 male patients with CLL aged 50–70 years, divided into group 1 (n = 34) without signs of osteopenia and group 2 (n = 14) with signs of osteopenia based on osteodensitometry (T-score from –1.0 SD to –2.5 SD). BMD, T- and Z-scores were assessed in the lumbar spine, proximal femoral neck (PFC), and proximal femur. In the bone tissue homogenate, the content of products of oxidative modification of proteins (OMP) was determined spectrophotometrically in spontaneous and metal-catalyzed modes, reserve-adaptation potential, and general antioxidant status.Results. Osteopenia was detected in 30 % of patients with CLL according to osteodensitometry in the neck of the proximal femur. In patients with CLL and osteopenia, signs of oxidative stress were observed in the bone tissue: early OMP products of a neutral and basic nature, late products of a neutral nature accumulated in the spontaneous detection mode; early and late OMP products of a neutral and basic nature accumulated in the induced mode; reserve-adaptive potential, the general antioxidant status decreased. Signs of osteopenia in the PFC in patients with CLL in the femoral neck increased as the content of early and late OMP products in the bone tissue increased in spontaneous and metal-induced detection modes, and the general antioxidant status in the bone tissue decreased.Conclusion. Based on the data obtained, it is possible to modernize diagnostic criteria and therapeutic approaches.
Clinical application of a low-volume extracorporeal photochemotherapy for the treatment of graft-versus-host disease
Authors: Kumukova I. B. , Kurnikova E. E. , Garloeva J. N. , Trakhtman P. E. , Balashov D. N. , Shelikhova L. N. , Skvorcova J. V. 
Published: December 2024

Introduction. Extracorporeal photopheresis (ECP) is an attractive method of treating graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation due to the lack of systemic immunosuppression. However, the clinical use of ECP is often limited by the need for leukapheresis. There are modifications of ECP without the use of leukapheresis, in particular low-volume ECP.Aim: to analyze the use of lv-ECP for the treatment of patients with acute and chronic GvHD.Patients and methods. The results of treatment of 9 cases of acute GVHD and 15 cases of chronic GVHD using the lv-ECP from April 2021 to March 2024 are presented. The cellular product was obtained by effusion of 15-30 ml of whole blood followed by photochemical treatment. The processed autologous cell product was administered to the patient.Results. The overall response in patients with acute GVHD was 44%, organ-specific response for skin lesions was 56 %, and for gastrointestinal lesions, 40%. In the treatment of chronic GvHD, the overall response was 73.3 %; the effectiveness of therapy for skin lesions was 71 %; for gastrointestinal lesions 67 %; for lung damage 67 %; for eye damage 100 %, for liver damage 100 %.Conclusion. lv-ECP has shown promising efficacy results in the treatment of acute and chronic GvHD. lv-ECP is an attractive alternative to standard ECP when leukapheresis is not possible.
Analysis of the usability of graphical interfaces of car rental websites with consideration of universal design principles
Authors: Szewczyk Jakub , Skublewska-Paszkowska Maria 
Published: December 2024

The study presents an analysis of two versions of a car rental website’s graphical interface in terms of usability and accessibility. a literature review was conducted to clarify concepts such as universal design, usability, and user experience. Two types of the car rental website were developed: one adhering to universal design principles and the other not considering these principles. The research employed tools such as WAVE, surveys, the LUT checklist, and an eye tracker. Metrics like time to first fixation and user ratings were analyzed. The experiments demonstrated that the website following universal design principles is more intuitive and user-friendly. Heatmaps and gaze paths illustrate that the version developed according to universal design principles significantly facilitates users in finding the information they need. Survey results proved that users rate websites developed according to universal design principles significantly
HETEROSIS AND GENE ACTION FOR YIELD AND YIELD COMPONENTS AND Maize (Zea mays L.), USING HALF DIALLEL CROSSES.
Authors: Shapal hasan Ramadan  , A. T.  Mohammed A. Hussain  
Published: December 2024

Experiment of half diallel cross among eight maize inbred lines was carried out during spring 2021.The varietal traits for F1 cross and parents with local hybrid were conducted during autumn 2021 Field of College of Agricultural Engineering Sciences , University of Duhok, using Randomized Complete Block Design with three replications .The results were revealed that the analysis of variance for genotypes and general and specific combining ability were significant effect on studied traits , also the ratio of degree of dominance is less then one for all traits . The cross 7x8 gave the heighest value ( 219.35g) for grain yield per plant and the same cross gave positive significant heterosis over mid parent , best parent and local hybrid .The heritability were high for number of ear per plant and ear diameter with value( 0.55) and( 0.45) respectively, the expected genetic advance was low for yield and yield components.
ISOLATION AND IDENTIFICATION OF ALLELOPATHIC COMPOUNDS FROM THE RESIDUES OF SOME SUNFLOWER CULTIVARS USING HPLC TECHNOLOGY
Authors: Alaa A. J. AL-Behadili  
Published: December 2024

This research was conducted to detect some of the allelopathic chemical class in plant residues of nine cultivars of sunflower, including Zahret Al-Iraq, Luleo, Turkie, Al-Isaqi 1, Al-Isaqi 2, Tarzan, Akmar, Shumoos, and Sin Al-Theeb, using appropriate chemical reagents. Some of these chemical were furthered analysed for their content of allelopathic comopounds using High-Performance Liquid Chromatography (HPLC). Results revealed the presence of glycosides, alkaloids, tannins, terpenes, steroids and flavonoids the plant residues of the test sunflower cultivars. Concentrations of glycosides, tannins, alkaloids, and flavonoids were measured, were found to be highter in Shumoos and Tarzan 1018 cultivar residues. The analysis with the High-Performance Liquid Chromatography (HPLC) indicated the presence of several allelopathic compounds of phenolic in nature in the different sunflower cultivar residues, namely Rutin, Vanillin, Resorcinol, and Quercetin.
USING CELLULOSE GUM TO IMPROVE THE PHYSICOCHEMICAL, RHEOLOGICAL, AND SENSORY PROPERTIES OF LOW-FAT MOZZARELLA CHEESE
Authors: Shaymaa Saady Lafta  
Published: December 2024

This study was aimed to investigate the potential of cellulose gum as a substitute for fat in Mozzarella cheese production and evaluate its impact on the cheese's physicochemical, rheological, and sensory properties. Cellulose gum was added in different ratios of 0.1, 0.2, 0.3, 0.4, and 0.5%, revealing treatments A1, A2, A3, A4, and A5 to skimmed milk, respectively. As well as the positive control treatment C+ manufactured from whole milk, there is a negative control treatment C- made from skimmed milk without cellulose gum. After processing, several tests were conducted to determine the quality of the product. Chemical tests were carried out to measure moisture, protein, fat, lactose, and ash and total acidity percentage. Physical tests were also conducted, including, pH, compression, and elasticity measurements. In addition, sensory evaluations were conducted immediately and after 120 days of storage at (5 ± 1) º C. The results revealed that the cellulose gum treatments contained a higher moisture content than C+ and C- recorded at 48.13 and 50.40 %, respectively. In comparison, it varied from 56.85 to 55.00 % for cellulose gum treatments A2 (the best treatment in sensory properties). During 120 days of storage at (5±1)ºC, all treatment values significantly reduced moisture content. Fat content increased significantly in all cellulose gum-treated skimmed milk, while lactose percentage remained constant across all treatments. Adding cellulose gum to cheese production improved its rheological test results for compression and elasticity compared to the control group. Also, adding cellulose gum enhanced cheese yield and improved the sensory properties of low-fat Mozzarella cheese.
INFLUENCE OF MEDICINAL PLANTS AND VITAMIN E ON PRODUCTIVE PERFORMANCE AND SOME PHYSIOLOGICAL PARAMETERS OF BROILER CHICKENS UNDER HEAT STRESS
Authors: Galawezh Kh. Qader  , Ihsan T.Tayeb  
Published: December 2024

This study was aimed to evaluate the influence of adding dietary three medicinal plants and vitamin E on productive performance, serum physiological parameters, immunity and antioxidant status of broiler chickens under heat stress (34 - 38) C° for 35 days. A total of 600 Ross one day old broiler chicks were distributed randomly into eight treatments with five replicates 15 birds per each replicate as follows: T1: broiler were fed standard ration (negative control); T2: 50 mg vitamin E /kg ration (positive control); T3: 5g Dill powder /kg ration; T4: 10g Dill powder /kg ration; T5: 5g Adiantum powder /kg ration; T6: 10g Adiantum powder /kg ration; T7: 5g Crataegus powder /kg ration and T8: 10g Crataegus powder /kg ration. Live body weight, feed intake, feed conversion ratio and mortality rate were measured at weekly intervals. There was a significant effect of medicinal plants on live body weight at 35 day. However, non-significant difference was noticed on feed intake, significant differences on feed conversion ratio, mortality and livability%. Regarding male chickens, T3 treatment had significantly higher carcass yield as well as each of T3 male and T4 female had higher dressing percentage. Furthermore, higher production index was found in T4 while, high value of economic figure was shown in T5 as well as significant effect on serum thyroid hormone T3,T4, corticosterone hormone and enhanced total antioxidant capacity and stable malondialdehyde all helped to reduce oxidative stress as well as boost antibody titers of ND and IBD compared with T1. It can be concluded that the supplementation of medicinal plants to broiler´s diet had a beneficial effect on most of broiler performance, improving immunity, resistance characteristics and oxidative stress particularly in T4 (Dill10g/kg) under heat stress.