bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ayuda ergonómica para atenuar trastornos osteomioarticulares por levantamiento manual de cargas en el despacho de pollos pelados
Authors: Pilatásig Villamarín Stefany Maritza , Córdova Suárez Manolo Alexander , Villacres Cevallos Edison Patricio 
Published: October 2021

Introducción, la ejecución de actividades artesanales donde no se considera gestión de la prevención y menos ayudas ergonómicas exponen a los trabajadores a condiciones severas de trabajo por el levantar cargas de diferentes pesos todo el día puede ocasionar trastornos osteomioarticulares y hasta accidentes laborales. Objetivo. Se investigó el efecto de una ayuda ergonómica para disminuir a la mitad el peso de las cargas que levanta el despachador de gavetas de pollos de la empresa Incubandina y atenuar el índice de levantamiento compuesto del National Institute for Occupational Safety and Health (NIOSH) compuesto. Metodología. Primero se empezó identificando: tiempo de ejecución de los levantamientos, peso de la carga, posición vertical (V), posición horizontal (H), altura del levantamiento (D), ángulo de giro (A), frecuencia de los levantamientos (F) y el agarre. Luego se efectuó el cálculo del índice individual de cada carga y al final el índice de levantamiento compuesto para múltiples tareas, realizando los arreglos de los factores del NIOSH utilizando la NTP 477. Esto se realizó en condiciones iniciales y luego con la ayuda ergonómica para ver el porcentaje de mejora. Resultados. Se identificó el levantamiento de cuatro cargas diferentes: 20kg, 25 kg, 18 kg, 20 kg; de los cuales se calculó los índices de levantamientos individuales determinando: 1,15; 1,51; 1,24 y 1,28 respectivamente y un índice de levantamiento compuesto de 2,42. Al ubicar un puesto espejo y compartir las cargas se encontró un índice de levantamiento individual de: 0,49; 0,62; 0,46; y 0,52 respectivamente y un índice de levantamiento compuesto de 0,6 Disminuyendo un 182% el índice de levantamiento compuesto. Conclusión. Con el uso de una persona que ayude al levantamiento manual de las cargas se logra bajar un 182 % el índice de levantamiento compuesto garantizando la ejecución de la actividad dentro de los límites recomendados por la legislación ecuatoriana en el DE 23 93 Art. 128 Lit. 4.
Distribution pattern of chigger mites in south Tamil Nadu, India
Authors: Govindarajan R. , Rajamannar V. , Krishnamoorthi R. , Kumar Ashwani , Samuel P. Philip 
Published: October 2021

Chiggers, the larval Trombiculid mites are the vectors for scrub typhus. Rodents and shrews are the preferred host. Study made at different habitats of chiggers collected in rodents and shrews, revealed more number to Rattus rattus 95(63%) and Suncus murinus 33(22%). Rattus rattus 31(54%) and Suncus murinus 17(30%) alone contributed more in chigger positivity. Chigger mites belonged to eight species under five genera. Leptotrombidium deliense (66%), Schoengatiella ligula (15%), and other chiggers (9%) were collected from 57 positive rodents. Seasonally, there was a significant difference in rodent positivity, and there was no significant difference in the number of chiggers collected. The study indicated the prevalence of chiggers in the various hosts and their variation in rodent/shrew hosts. R. rattus 31(54%) and S. murinus 17(30%) contributed more in chiggers infestation and seasonally wet-cool months favored more chiggers and host positivity from different habitats.
Report of Sastroides besucheti Medvedev (Coleoptera, Chrysomelidae) on Malabar nutmeg
Authors: Nafeesa M. , Murugan Muthusamy 
Published: October 2021

Massive infestation of Sastroides besucheti Medvedev (Coleoptera: Chrysomelidae), is reported on Malabar nutmeg Myristica malabarica Lam.(Myristicaceae), endemic to south India. All the 25 trees in the study area were infested; however, the intensity was lesser on male plants. Eggs, larvae, prepupae and pupae were observed. Pattern of egg laying, feeding habit of grubs and site of pupation were recorded. Infested female trees shed more than 70 per cent of the leaves and the branches dried up from tip downwards. Survival and regeneration of heavily infested female trees are doubtful. This is the first report of S. besucheti on M. malabarica.
Biology of Attagenus fasciatus Thunberg (Coleoptera: Dermestidae) on four different diets of animal origin
Authors: Ansari M.F. 
Published: October 2021

Biology of dermestid beetle, Attagenus fasciatus was studied on four different diets of animal origin included dried silkworm pupae and moths of Bombyx mori, feathers of white leghorn and on an equal mixture of fur of goat and sheep under laboratory conditions, to know the dietary effect on the developmental process. The mean incubation period was 12-16 days. There were 10-12 larval instars. The life-cycle on four different diets of animal origin varied. On dried silkworm pupae, total larval period ranged from 243 to 298 days and total life-cycle 267-326 days; on dried silk moths, total larval period was 251-307 and total life-cycle 272-330 days; on feathers of white leghorn, total larval period was 264-329 and total life-cycle was 288-355 days, and on an equal mixture of fur of goat and sheep, total larval period was 273-317 and total life-cycle was 297-343 days.
Macrohymenopteran diversity in Thommana Kole wetland, Thrissur, India
Authors: Anas P.P. Mohammed , Prakash Anju Sara , Bijoy C. , Mohamed H. E. Syed 
Published: October 2021

The study conducted on the diversity of macrohymenoptera at the Thommana Kole wetland, Thrissur, Kerala revealed 36 species from 24 genera and 9 families.
Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment
Authors: Muñoz César , Guevara Lissette , Escamilla María-Isabel , Regino Ronald , Acevedo Nathalie , Escamilla-Arrieta Jose Miguel 
Published: October 2021

Introduction: The severity of wheezing episodes is related with the need for health services, but the factors associated with health care utilization in preschool recurrent wheezers in underdeveloped regions are unclear.Objective: To evaluate the factors associated with health care utilization in preschool recurrent wheezers in Cartagena, Colombia.Methods: One hundred twenty-seven recurrent wheezers (age 2–6 years old) who were admitted to the emergency room (ER) due to wheezing in a Pediatric reference hospital in Cartagena were included. Children were evaluated by means of questionnaires and classified according to the number of ER visits, need for hospitalization and history of intensive care unit (ICU) admission due to wheezing within the last year. Total serum IgE and specific IgE to house dust mite allergens (HDM) were measured by ImmunoCAP® and allergen sensitization was evaluated by skin prick tests (SPT).Results: The maternal report of nocturnal cough without fever in their children increased the risk to have ≥5 ER visits in the last year due to wheezing. The use of montelukast was negatively associated with hospitalization, while a history of pneumonia and lack of tap water, increased the risk of hospitalization due to wheezing. A history of bronchiolitis, family history of asthma, cohabiting with two or more siblings, passive exposure to smoke and lack of sewage facilities increased the risk of ICU admission due to wheezing. The presence of atopy evaluated by SPT reactivity, total IgE levels or specific IgE to HDM were not associated with health care utilization. We also found that seroprevalence of positive IgE (≥0.35 kU/L) was 27% to B. tropicalis and 20.3% to D. pteronyssinus but the prevalence of positive IgE sensitization to these allergens was below 2% and 8% when evaluated by SPT, respectively.Conclusions: Poverty indicators are associated with ICU admission in a group of preschool recurrent wheezers and should be considered as aggravating factors for wheezing. These factors must be systematically assessed in the medical approach in underdeveloped regions in the tropics. Nocturnal cough without fever is a symptom associated with frequent ER visits while atopy was not associated with health care utilization in preschool recurrent wheezers.
Targeted Bisulfite Sequencing Reveals DNA Methylation Changes in Zinc Finger Family Genes Associated With KRAS Mutated Colorectal Cancer
Authors: Pu Weilin , Qian Fei , Liu Jing , Shao Keke , Xiao Feng , Jin Qin , Liu Qingmei , Jiang Shuai , Zhang Rui , Zhang Jun , Guo Shicheng , Zhang Jianfeng , Ma Yanyun , Ju Shaoqing , Ding Weifeng 
Published: October 2021

Background: Colorectal cancer (CRC) is a leading cause of cancer death, and early diagnosis of CRC could significantly reduce its mortality rate. Previous studies suggest that the DNA methylation status of zinc finger genes (ZFGs) could be of potential in CRC early diagnosis. However, the comprehensive evaluation of ZFGs in CRC is still lacking.Methods: We first collected 1,426 public samples on genome-wide DNA methylation, including 1,104 cases of CRC tumors, 54 adenomas, and 268 para-tumors. Next, the most differentially methylated ZFGs were identified and validated in two replication cohorts comprising 218 CRC patients. Finally, we compared the prediction capabilities between the ZFGs and the SEPT9 in all CRC patients and the KRAS + and KRAS- subgroup.Results: Five candidate ZFGs were selected: ESR1, ZNF132, ZNF229, ZNF542, and ZNF677. In particular, ESR1 [area under the curve (AUC) = 0.91] and ZNF132 (AUC = 0.93) showed equivalent or better diagnostic capability for CRC than SEPT9 (AUC = 0.91) in the validation dataset, suggesting that these two ZFGs might be of potential for CRC diagnosis in the future. Furthermore, we performed subgroup analysis and found a significantly higher diagnostic capability in KRAS + (AUC ranged from 0.97 to 1) than that in KRAS- patients (AUC ranged from 0.74 to 0.86) for all these five ZFGs, suggesting that these ZFGs could be ideal diagnostic markers for KRAS mutated CRC patients.Conclusion: The methylation profiles of the candidate ZFGs could be potential biomarkers for the early diagnosis of CRC, especially for patients carrying KRAS mutations.
High Serum Carbohydrate Antigen (CA) 125 Level Is Associated With Poor Prognosis in Patients With Light-Chain Cardiac Amyloidosis
Authors: Li Muzheng , Wu Zhijian , Tudahun Ilyas , Liu Na , Lin Qiuzhen , Liu Jiang , Wang Yingmin , Chen Mingxian , Chen Yaqin , Qi Nenghua , Zhu Qingyi , Li JunLi , Li Wei , Tang Jianjun , Liu Qiming 
Published: October 2021

Background and Aims: Patients with light-chain cardiac amyloidosis (AL-CA) are characterized by high levels of serum carbohydrate antigen 125 (CA 125). However, studies have not explored the correlation between CA 125 and AL-CA. The aim of this study was to explore the clinical implications of an increase in CA 125 in patients with AL-CA.Methods and Results: A total of 95 patients diagnosed with AL-CA at the Second Xiangya Hospital were enrolled in this study. Out of the 95 patients with AL-CA, 57 (60%) patients had elevated serum CA 125 levels. The mean age was 59.7 ± 10.0 years with 44 (77.2%) men in the high serum CA 125 group, and 61.8 ± 9.6 years with 28 (73.7%) men in the normal group. Patients with high CA 125 showed higher rates of polyserositis (79.3% vs. 60.5%, p = 0.03), higher levels of hemoglobin (117.4 ± 21.9 g/L vs. 106.08 ± 25.1 g/L, p = 0.03), serum potassium (4.11 ± 0.47 mmol/L vs. 3.97 ± 0.40 mmol/L, p = 0.049), low-density lipoprotein-cholesterol (3.0 ± 1.6 mmol/L vs. 2.3 ± 1.10 mmol/L, p = 0.01), and cardiac troponin T (96.0 pg/mL vs. 91.9 pg/mL, p = 0.005). The median overall survival times for patients with high or normal serum CA 125 were 5 and 25 months, respectively (p = 0.045). Multivariate Cox hazard analysis showed that treatment without chemotherapy (HR 1.694, 95% CI 1.121–2.562, p = 0.012) and CA 125 (HR 1.002, 95% CI 1.000–1.004, p = 0.020) was correlated with high all-cause mortality. The time-dependent receiver operating characteristic (t-ROC) curve showed that the prediction accuracy of CA 125 was not inferior to that of cardiac troponin T, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and lactate dehydrogenase (LDH) based on the area under the curve.Conclusions: CA 125 is a novel prognostic predictor. High serum CA 125 values are correlated with low overall survival, and the accuracy of predicting prognosis is similar to that of traditional biomarkers in AL-CA.
The Evolution of Peteroa Volcano (Chile–Argentina) Crater Lakes Between 1984 and 2020 Based on Landsat and Planet Labs Imagery Analysis
Authors: Aguilera Felipe , Caro Javiera , Layana Susana 
Published: October 2021

One of the major challenges in the understanding of the crater lakes dynamics and their connection with magmatic/hydrothermal processes is the continuous tracking of the physical behavior of lakes, especially in cases of remote and poorly accessible volcanoes. Peteroa volcano (Chile–Argentina border) is part of the Planchón–Peteroa–Azufre Volcanic Complex, one of the three volcanoes in the Southern Volcanic Zone of the Andes with crater lakes. Peteroa volcano is formed by a ∼5 km diameter caldera-type crater, which hosts four crater lakes and several fumarolic fields. Peteroa volcano has a large history of eruptive activity including phreatic-and-phreatomagmatic explosions and several episodes of strong degassing from its crater lakes. Here, we used TIR and SWIR bands from Landsat TM, ETM+, and OLI images available from October 1984 to December 2020 to obtain thermal parameters such as thermal radiance, brightness temperature, and heat fluxes, and Planet Labs Inc. images (RapidEye and PlanetScope) available between May 2009 and December 2020 to obtain physical parameters such as area, color, and state (liquid or frozen) of the crater lakes. We reviewed the historical eruptive activity and compared it with thermal and physical data obtained from satellite images. We determined the occurrence of two eruptive/thermal cycles: 1) Cycle 1 includes the formation of a new fumarolic field and two active craters during a short eruptive period, which includes thermal activity in three of the four crater lakes, and a strong degassing process between October 1998 and February 2001, coincident with a peak of volcanic heat flux (Qvolc) in two craters. The cycle finished with an eruptive episode (September 2010–July 2011). 2) Cycle 2 is represented by the thermal reactivation of two crater lakes, formation and detection of thermal activity in a new nested crater, and occurrence of a new eruptive episode (October 2018–April 2019). We observed a migration of the thermal and eruptive activity between the crater lakes and the interconnection of the pathways that feed the lakes, in both cases, partially related to the presence of two deep magma bodies. The Qvolc in Peteroa volcano crater lakes is primarily controlled by volcanic activity, and seasonal effects affect it at short-term, whilst at long-term, seasonal effects do not show clear influences in the volcanic heat fluxes. The maximum Qvolc measured between all crater lakes during quiescent periods was 59 MW, whereas during unrest episodes Qvolc in single crater lakes varied from 7.1 to 38 MW, with Peteroa volcano being classified as a low volcanic heat flux system. The detection of new thermal activity and increase of Qvolc in Peteroa volcano previous to explosive unrest can be considered as a good example of how thermal information from satellite images can be used to detect possible precursors to eruptive activity in volcanoes which host crater lakes.
Mechanical Thrombectomy for Acute Stroke Due to Large-Vessel Occlusion Presenting With Mild Symptoms
Authors: Liu Feifeng , Shen Hao , Chen Chen , Bao Huan , Zuo Lian , Xu Xiahong , Yang Yumei , Cochrane Alexia , Xiao Yaping , Li Gang 
Published: October 2021

Purpose: To evaluate the safety and efficacy of mechanical thrombectomy (MT) for acute stroke due to large vessel occlusion (LVO), presenting with mild symptoms.Methods: A prospective cohort study of patients with mild ischemic stroke and LVO was conducted. Patients were divided into two groups: MT group or best medical management (MM) group. Propensity score matching (PSM) was conducted to reduce the confounding bias between the groups. The primary outcome was functional independence at 90 days. The safety outcome was symptomatic intracranial hemorrhage (sICH). Univariate and multivariate logistic regression analyses were used to identify the independent factors associated with outcomes.Results: Among the 105 included patients, 43 were in the MT group and 62 in the MM group. Forty-three pairs of patients were generated after PSM. There were no significant differences in sICH rates between two groups (p = 1.000). The MT group had a higher proportion of independent outcomes (83.7% MT vs. 67.4% MM; OR 2.483; 95% CI 0.886–6.959; p = 0.079) and excellent outcomes (76.7% MT vs. 51.2% MM; OR 3.150; 95% CI 1.247–7.954; p = 0.013) compared to the MM group, especially in patients with stroke of the anterior circulation (p &lt; 0.05). Multivariate logistic regression analysis showed that small infarct core volume (p = 0.015) and MT treatment (p = 0.013) were independently associated with excellent outcomes.Conclusions: Our results suggest that MT in stroke patients, presenting with mild symptoms, due to acute LVO in the anterior circulation may be associated with satisfactory clinical outcomes.Clinical Trial Registration:ClinicalTrials.gov, identifier: NCT04526756.
Economic Evaluation of Sacituzumab Govitecan for the Treatment of Metastatic Triple-Negative Breast Cancer in China and the US
Authors: Chen Jigang , Han Mingyang , Liu Aihua , Shi Bo 
Published: October 2021

BackgroundThe effectiveness of Sacituzumab Govitecan (SG) for metastatic triple-negative breast cancer (mTNBC) has been demonstrated. We aimed to evaluate its cost-effectiveness on mTNBC from the Chinese and United States (US) perspective.MethodsA partitioned survival model was developed to compare the cost and effectiveness of SG versus single-agent chemotherapy based on clinical data from the ASCENT phase 3 randomized trial. Cost and utility data were obtained from the literature. The incremental cost-effectiveness ratio (ICER) was measured, and one-way and probabilistic sensitivity analyses (PSA) were performed to observe model stability. A Markov model was constructed to validate the results.ResultsIn China, SG yielded an additional 0.35 quality-adjusted life-year (QALY) at an additional cost of Chinese Renminbi ¥2257842. The ICER was ¥6375856 ($924037)/QALY. In the US, SG yielded the same additional QALY at an extra cost of $175393 and the ICER was $494479/QALY. Similar results were obtained from the Markov model. One-way sensitivity analyses showed that SG price had the greatest impact on the ICER. PSA showed the probability of SG to be cost-effective when compared with chemotherapy was zero at the current willing-to-pay threshold of ¥217341/QALY and $150000/QALY in China and the US, respectively. The probability of cost-effectiveness of SG would approximate 50% if its price was reduced to ¥10.44/mg in China and $3.65/mg in the US.ConclusionSG is unlikely to be a cost-effective treatment of mTNBC at the current price both in China and the US.
Elevated Lactate Dehydrogenase Levels Display a Poor Prognostic Factor for Non-Hodgkin’s Lymphoma in Intensive Care Unit: An Analysis of the MIMIC-III Database Combined With External Validation
Authors: Qi Jiaqian , Gu Chengyuan , Wang Weijuan , Xiang Mengqi , Chen Xiaochen , Fu Jianhong 
Published: October 2021

BackgroundAmong the growing number of patients with hematologic neoplasms hospitalized in the intensive care unit (ICU), the largest proportion of these patients are diagnosed with lymphoma. However, less attention has been paid in the past to identifying critically ill patients and assessing the prognosis of patients in ICU. Traditional critical care-related scores have shown limitations and inaccuracy in predicting mortality risk.MethodsPatients diagnosed with diffuse large B-cell lymphoma (DLBCL) were searched for in the Marketplace for Information in Intensive Care Medicine III (MIMIC-III) database. We searched mortality within 28 days as the primary endpoint. Logistics regression was used to screen risk factors. A calibration curve was used for internal validation, and the ROC curve and AUC were used to compare the new model with traditional scores.Results405 patients with DLBCL are enrolled in the project. Multivariate analysis shows the patients with the level of lactate dehydrogenase (LDH) &gt; 327 U/L had an increased risk of 28-day mortality in ICU than others (OR = 13.04, p&lt;0.01). Notably, length of ICU stay, LDH, creatinine, white blood cell counts, and APS III score are independent prognostic factors for patients with DLBCL in the ICU. Then, all these independent prognostic factors are selected into our prediction model. The new model has good accuracy (C-index=0.863) and a calibration curve, which improves clinical status concerning established ratings such as IPI, NCCN-IPI score, SOFA, APS III, and LODS. The results of a multicenter external validation including 124 DLBCL patients also showed that the new model was more accurate than all other models.ConclusionsThe elevated level of LDH indicates a poor prognosis of patients with DLBCL in the ICU. Our risk score with crossed validation based on the level of LDH shows a significant prognostic value and may be a valuable tool for assessing the critically ill as well.
The Value of MicroRNA-375 Detection for Triaging Primary Human Papillomavirus Positive Women: A Cross-Sectional Study in a General Population
Authors: Wu Qiongyan , Wang Lingfang , Zhao Xiumin , Tian Qifang , Wang Fenfen , Sima Ni , Qiu Liqian , Lu Weiguo , Xie Xing , Wang Xinyu , Cheng Xiaodong 
Published: October 2021

PurposeThis study aims to validate the value of microRNA (miRNA) detection for triaging human papillomavirus (HPV)-positive women in the general population.Patients and MethodsmiR-375 detection in cervical exfoliated cells has been demonstrated to have the superior value to cytology in triaging primary HPV-positive women in the hospital population. In this study, residual samples of cervical exfoliated cells from 10,951 women in a general population were used to detect miRNA. The performance efficiency of miRNA detection in identifying high-grade cervical intraepithelial neoplasia (CIN) was evaluated. Pearson chi-square test and McNemar pairing test were used to compare miRNA detection and cytology.ResultsIn valid 9,972 women aged 25–65, miR-375 expression showed a downward trend along with an increase in cervical lesion severity. The expression level of miR-375 ≤1.0 × 10-3 was identified as positive. In the HPV-positive and 12 HPV genotypes other than 16/18 (HR12)-positive women, miR-375 detection showed equivalent sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) to that of cytology (≥ASC-US) and higher or similar sensitivity and NPV but lower specificity and PPV than that of cytology (≥ASC-H) in identifying CIN3+ and CIN2+. In HPV 16-positive women, miR-375 positivity had higher sensitivity and NPV but lower specificity and PPV than that of cytology (≥ASC-H and HSIL) in identifying CIN3+ and CIN2+. The immediate CIN3+ risk of miR-375 positivity was 19.8% (61/308) in HPV-positive, 10.8% (22/204) in HR12-positive, and 43.5% (37/85) in HPV16-positive women, respectively.ConclusionThe detection of miR-375 in cervical exfoliated cells may be an optional method for triaging primary HPV-positive women in population-based cervical cancer screening.