bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dibujar lo indecible: La poliédrica presencia de la homosexualidad en la plástica poética de Federico García Lorca
Authors: Oliva Jesús Martínez 
Published: December 2021

En el corpus de la obra gráfica lorquiana nos encontramos con múltiples trazas y formas de abordar la homosexualidad desde diversas temáticas, tropos y estrategias plásticas en las que, de forma cruzada, cohabitan la exposición y la ocultación enmascarada de la misma, no llegando a expresarse de un modo coherente y estable. Quizás esta sea una de las características más destacables de su obra plástica, aunque a veces se haya pasado por alto al reducir la presencia de la homosexualidad al mero homoerotismo más directo y evidente de algunos dibujos de marineros o de efébicos gitanos. Este artículo pretende revisar un aspecto al que, a pesar de ser un enfoque cada vez más concitado, no se le ha prestado una atención global. De igual modo, está entre sus objetivos trazar una primera cartografía de las diversas presencias de la homosexualidad albergadas en el complejo magma de la obra plástica lorquiana.
Carcinoma do Ducto Salivar
Authors: Rodrigues Matiello Luiza , Reis de Sousa Zacarias Juliana , Zambaldi da Cruz Eduardo , Rodrigues Lima Sandro Regis , Garcia Rosa Ana Cláudia , Passador Santos Fabrício 
Published: December 2021

O carcinoma do ducto salivar (CDS) é um tumor raro que se origina das glândulas salivares maiores (parotidas, submandibulares e sublinguais) ou das salivares glândulas menores. Apresenta semelhança histológica com o carcinoma de ducto mamário (CDM) de alto grau. É um tumor agressivo, de rápida progressão e com alta taxa de mortalidade, acometendo majoritariamente homens na sexta ou sétima década de vida. Este trabalho tem por objetivo relatar um caso de CDS agressivo e fatal. O paciente deste estudo apresentou uma massa dolorosa, normocrômica e endurecida na região do mento, além de discreta linfoadenopatia submandibular bilateral. O exame de tomografia computadorizada mostrou uma lesão nodular circunstrita mal definida, isodensa, na região mentual, com comprometimento ósseo. Foi feita a biópsia incisional. A análise histopatológica mostrou uma neoplasia de origem glandular não encapsulada invadindo o tecido muscular. As reações imuno-histoquímicas para citoqueratinas (CK) AE1/AE3, CK7 e c-erbB-2 (HER2/neu) foram positivas. O diagnóstico foi CDS. Devido à rápida evolução do tumor e à presença de metástases à distância, o tratamento não foi bem sucedido e o paciente veio a óbito sete meses após diagnóstico. O CDS pode apresentar positividade para marcadores como receptores de andrógenos (AR), c-erbB-2 (HER2/neu), dentre outros, alguns também presentes no CDM.
PERFIL EPIDEMIOLÓGICO DE MENINGITE NO ESTADO DO TOCANTINS ENTRE 2009 E 2019
Authors: Soares Martins Gustavo , Fernandes Ribeiro Guilherme , Gomes Martins Correia Felipe , Maria Veloso Costa Coutinho Olívia 
Published: December 2021

Introdução: inflamação das membranas que revestem o cérebro e da medula espinhal, a meningite é uma patologia que acomete o sistema neurológico deixando sequelas e podendo levar à morte dos indivíduos. Fato esse que coloca a doença como uma das mais graves em se tratando de doenças neurológicas. Nesse contexto, o aumento do quantitativo de casos de internação e óbito no Tocantins devido à meningite torna oportuno e precípuo a realização da pesquisa, haja vista a gravidade dessa doença.
Objetivo: traçar o perfil epidemiológico das internações e óbitos ocasionados por meningite no Tocantins no período de 2009 a 2019.
Metodologia: coleta de informações do Sistema de Internações Hospitalares (SIH) - banco de dados do Departamento de Informação e Informática do SUS (DATASUS).
Resultados: foram registradas 625 internações, sendo 60% do sexo masculino e 34 óbitos sendo 61,7% do sexo masculino. A faixa etária mais acometida em relação às internações, foi do nascimento até os 19 anos com 72,32% internações, acerca dos óbitos o grupo mais afetado foi o de adultos do 20 aos 59 anos com 52,94% mortes
Conclusão: os registros de internações concentram-se em homens jovens, acerca dos óbitos há prevalência em homens adultos Conclui-se também grande desigualdade na distribuição de medidas preventivas entre os centros e periferias dos municípios.
MORBIMORTALIDADE POR CÂNCER DE COLO DO ÚTERO EM PALMAS E NO ESTADO DO TOCANTINS: UMA ANÁLISE EPIDEMIOLÓGICA DE 2000 A 2014
Authors: ROCHA SILVA CLARA LETICIA , Carvalho Angelica Gomes de , Artiaga de Carvalho Coelho Julia , De Sá Antunes Bezerra Palloma , Terra de Siqueira Peres Márcia Cristina 
Published: December 2021

Objetivo: Descrever e avaliar a tendência da morbimortalidade por câncer de colo do útero em Palmas e no estado do Tocantins durante os anos de 2000-2014. Método: Trata-se de um estudo ecológico de série temporal descritivo. Para o cálculo da taxa de mortalidade coletou-se o número de óbitos por câncer de colo do útero em mulheres no estado do Tocantins, de acordo com faixa etária. As informações epidemiológicas acerca da mortalidade por câncer de colo do útero foram coletadas na base de dados DATASUS através do Sistema de Informação sobre Mortalidade (SIM). O número de casos novos relatados na cidade Palmas utilizados para o cálculo das taxas de incidência foram obtidos a partir do Registro de Câncer de Base Populacional (RCBP). Resultado: A mortalidade observada em todas as faixas etárias no Tocantins e as taxas de incidência da doença na capital do estado indicam que estratégias que incluem vacinação para o vírus HPV, detecção precoce através de rastreio organizado, maior qualidade para os exames de screening e tratamento e seguimento adequado para as mulheres que apresentam exames alterados precisam ser reforçadas para que o cenário encontrado nessa região se altere dentro de alguns anos.
PALAVRAS-CHAVES: Câncer de Colo Uterino; Mortalidade; Incidência; Rastreamento.
Adaptation and Validation of The HIV-Kq-18 HIV Knowledge Questionnaire for Healthy Indonesian Population
Authors: Arifin Bustanul , Rokhman M. Rifqi , Zulkarnain Zulkarnain , Perwitasari Dyah Aryani , Manggau Marianti , Rauf Saidah , Noor Rasuane , Padmawati Retna Siwi , Postma Maarten Jacobus , Massi Muhammad Nasrum , Schans Jurjen van der 
Published: December 2021

Abstract
Background: Indonesia does not have a validated instrument to assess HIV/AIDS knowledge. The HIV-KQ-18 is one of the most extensively used instruments for assessing HIV/AIDS knowledge, and it has been translated into various languages throughout the world. This paper describes the process of adapting and validating the HIV-KQ-18, an instrument to assess the level of HIV/AIDS knowledge.Methods: In the adaptation phase, feedback for the initial Bahasa Indonesia version was gathered from two HIV activists, an obstetrician, two general practitioners, and 60 pilot participants from the physician. Additional descriptions (namely synonyms or examples) were added to the particular terms in the 6 items to make it more understandable.Results: In the validation phase 1,249 participants were recruited. The online link of HIV-KQ-18 Bahasa Indonesia was distributed to participants from six major regions in Indonesia. Internal consistency was measured using Cronbach’s alpha, while construct validity was determined using factor analysis. Based on visual observation of the scree tree in the factor analysis, one factor was preferable. The Cronbach's alpha was 0.82.Conclusion: Therefore, HIV-KQ-18 Bahasa Indonesia is a valid and reliable instrument to assess the level of HIV/AIDS knowledge in Indonesia.
To Identify Risk Factors Predicting Spontaneous Preterm Labor Less Than 28 Weeks After Emergency Cerclage in the Second Trimester of Pregnancy
Authors: Zhucan  , Ning Yu , Haiying Wu 
Published: December 2021

Abstract
Purpose To identify risk factors predicting spontaneous preterm labor (sPTB) less than 28 weeks after emergency cerclage in the second trimester of pregnancy.Methods 106 cases with Prolapsed membranes in the second trimester of pregnancy who underwent emergency cerclage were collected from July 2019-July 2021 .39 cases who happened sPTB less than 28 weeks were in case group. 67 cases were in control group.Univariate analysis and logistic regression analysis were used to identify the risk factors for sPTB less than 28 weeks after emergency cerclage.Results Among the 106 cases,37cases developed sPTB less than 28 weeks, and the incidence was 36.8%, Univariate analysis showed that positive cervical culture,cervical dilatation,the location of amniotic membranes and histologic chorioamnionitis were related with sPTB(P<0.05). Logistic regression analysis showed that histologic chorioamnionitis was the risk factors for sPTB after emergency cerclage in patients with Prolapsed membranes in the second trimester of pregnancy[relative risk14.603 ,95% confidence interval(CI)2.621-81.369,P<0.05].Amniotic membrane is an independent risk factor for less than 28 weeks of sPTB after emergency cerclage in middle pregnancy [relative risk11.993 ,95% confidence interval(CI)3.825-37.607,P<0.05].Conclusion The independent risk factors of sPTB less than 28 weeks after emergency cerclage with prolapsed membranes in the second trimester of pregnancy was histologic chorioamnionitis and Amniotic membrane.
β-Amyloid Protein Induces Mitophagy-Dependent Ferroptosis Through the CD36/PINK/PARKIN Pathway Leading to Blood-Brain Barrier Destruction in Alzheimer's Disease
Authors: Jianhua li , mengyu Li , Yangyang Ge , Jiayi Chen , Jiamin Ma , Chenchen Wang , Miaomiao Sun , Li Wang , shanglong Yao , chengye yao 
Published: December 2021

Abstract
Background

Blood-brain barrier (BBB) dysfunction may occur in the onset of Alzheimer's disease (AD). While pericytes are a vital part of the neurovascular unit and the BBB, acting as the gatekeeper of the BBB. Amyloid β (Aβ) deposition and neurofibrillary tangles in the brain are the central pathological features of AD. CD36 promotes vascular amyloid deposition and leads to vascular brain damage, neurovascular dysfunction, and cognitive deficits. However, the molecular mechanism in destroying pericytes of the BBB are still unclear.
Objectives

To investigate the effect of low-dose Aβ1-40 administration on pericyte outcome and BBB injury molecular mechanism.
Methods

We selected 6-month-old and 9-month-old APP/PS1 mice and wild-type (WT) mice of the same strain, age, and sex as controls. We assessed the BBB by PET/CT. Brain pericytes were extracted and cocultured with endothelial cells (bEnd.3) to generate an in vitro BBB model to observe the effect of Aβ1-40 on the BBB. Furthermore, we explored the intracellular degradation and related molecular mechanisms of Aβ1-40 after being engulfed in cells through CD36.
Results

BBB permeability and the number of pericytes decreased in APP/PS1 mice. Aβ1-40 increases the permeability of the BBB in an in vivo model and downregulates the expression of CD36, which reversed the Aβ-induced changes in BBB permeability. Aβ1-40 was phagocytized in pericytes with high expression of CD36. We observed that this molecule inhibited pericyte proliferation, caused mitochondrial damage, and increased mitophagy. Finally, we confirmed that Aβ1-40 induced pericyte mitophagy-dependent ferroptosis through the CD36/PINK1/Parkin pathway.
Conclusions

PDGFRβ (a marker of pericytes), CD36, and amyloid β colocalized in vitro and in vivo and that Aβ1-40 caused BBB destruction by upregulating the expression of CD36 in pericytes. The mechanism by which Aβ1-40 destroys the BBB involves induction of pericyte mitophagy-dependent ferroptosis through the CD36/PINK1/Parkin pathway.
Sitagliptin Attenuates Porphyromonas Gingivalis Virulence and Inflammatory Response in Macrophage on Titanium
Authors: Tang Weilong , Du Minquan , Zhang Shuang , Jiang Han 
Published: December 2021

Abstract
BackgroundIn peri-implantitis, porphyromonas gingivalis and macrophage play central roles. The aim of this study was to detect the attenuating effect of an anti-diabetic drug sitagliptin on porphyromonas gingivalis virulence and inflammatory response in macrophage on titanium discs. Materials and methodsPorphyromonas gingivalis and macrophage were cultured on titanium discs. Antibacterial and antibiofilm activities of sitagliptin were assessed and the morphology of porphyromonas gingivalis were observed by SEM. Bacterial early adhesion, aggregation, hemagglutination, hemolysis and porphyromonas gingivalis virulence factors mRNA expression were assessed to preliminarily investigate the mechanisms of action. Flow cytometry assay, qRT-PCR and Western Blot were used to assess the anti-inflammatory effect of sitagliptin on porphyromonas gingivalis lipopolysaccharide-stimulated macrophage. ResultsThe present study demonstrated the inhibiting effect of sitagliptin on the growth, biofilm, phenotypic behavior and virulence factors of porphyromonas gingivalis and the protective effect on the porphyromonas gingivalis lipopolysaccharide-induced polarization in macrophage. And we also confirmed the anti-inflammatory effect of sitagliptin on the secretion of inflammation-related factors in macrophage by inhibiting the MAPK and AKT signaling pathways. ConclusionsSitagliptin possesses the attenuating effect on porphyromonas gingivalis virulence and inflammatory response in porphyromonas gingivalis lipopolysaccharide-stimulated macrophage on titanium.
BMSCs and Pectin-Based E2-Loaded Microcapsules with Injectable Pectin-Pluronic® F-127 Scaffolds for Mouse Endometrial Regeneration Application
Authors: Wu Yuelin , Gu Shengyi , Cobb Jonathan M. , Dunn Griffin H. , Muth Taylor A. , Simchick Chloe J. , Li Baoguo , Zhang Wujie , Hua Xiaolin 
Published: December 2021

Abstract
Background
Uterine endometrium is a highly dynamic tissue which consists of a basal layer and a functional layer. Bone marrow-derived mesenchymal stem cells (BMSCs) have been recognized as new candidates for the treatment of serious endometrial injuries. However, due to the local microenvironment of damaged endometrium, transplantation of BMSCs yielded disappointing results with respect to survival, attachment, differentiation, and proliferation.
Methods
Pectin-Pluronic® F-127 scaffolds were fabricated. E2 was encapsulated into the W/O/W microspheres to construct pectin-based E2-loaded microcapsules (E2 MPs). The BMSCs/E2 MPs/scaffolds system was then injected into the uterine cavity of mouse endometrial injury model. Furthermore, the mechanism of E2 in promoting the repair of endometrial injury was also investigated.
Result
Pectin-Pluronic® F-127 scaffolds could provide three-dimensional architecture for the attachment, growth, and migration of BMSCs. E2 MPs has the potential to serve as a long-term reliable source of E2 for endometrial regeneration. At four weeks after transplantation, it was demonstrated that the system increased proliferative abilities of uterine endometrial cells, facilitated microvasculature regeneration, and restored the ability of endometrium to receive an embryo, suggesting that the BMSCs/E2 MPs/scaffolds system is a promising treatment option for endometrial regeneration. Exosomes are critical paracrine mediators that act as biochemical cues to direct stem cell differentiation. In this study, it was found that the expression of endometrial epithelial cells (EECs) markers was up-regulated in BMSCs treated by exosomes secreted from endometrial stromal cells (ESCs-Exos). Exosomes derived from E2-stimulated ESCs further promoted the expression level of EECs markers in BMSCs, suggesting exosomes released from ESCs by E2 stimulation could enhance the differentiation efficiency of BMSCs.
Conclusion
The BMSCs/E2 MPs/scaffolds therapeutic strategy may be beneficial in the treatment of severely damaged endometrium. Exosomes derived from ESCs play paracrine roles in endometrial regeneration stimulated by E2, potentially modulating the differentiation of BMSCs.
Enriched Environment Causes Epigenetic Alterations in the Hippocampus and Improve Long-term Cognitive Function Sepsis-Induced
Authors: Córneo Emily , Michels Monique , Abatti Mariane , Vieira Andriele , Gonçalves Renata Casagrande , Gabriel Filipe Fernandes , Borges Heloisa , Goulart Amanda , Matos Natan Silva , Dominguini Diogo , Varela Roger , Valvassori Samira , Dal-Pizzol Felipe 
Published: December 2021

Abstract
Background: Sepsis is defined as the presence of life-threatening organ dysfunction. The presence of oxidative stress and inflammatory mediators in sepsis leads to dysregulated gene expression, leading to a hyperinflammatory response. Environmental conditions play an important role in various pathologies depending on the stimulus it presents. A standard environment may offer reduced sensory and cognitive stimulation, but an enriched environment improves spatial learning, prevents cognitive deficits induced by disease stress, and is an important modulator of epigenetic enzymes. The study evaluated the epigenetic alterations and the effects of the environmental enrichment (EE) protocol in the brain of animals submitted to sepsis by cecal ligation and perforation (CLP). Methods: Male Wistar rats were divided into sham and CLP at 24 hours, 72 hours, 10 days and 30 days after sepsis. Other male Wistar rats were distributed in a standard environment or in EE for forty-five days. Behavioral tests, analysis of epigenetic enzymes:histone acetylase (HAT), histone deacetylase (HDAC) and DNA methyltransferase (DNMT), biochemical and synaptic plasticity analyzes were performed. Results: An increase in HDAC and DNMT activities was observed at 72 hours, 10 days and 30 days. There was a positive correlation between epigenetic enzymes DNMT and HDAC 24 hours, 10 days and 30 days. After EE, HDAC and DNMT enzyme activity decreased, cognitive impairment was reversed, IL1-β levels decreased and there was an increase in PSD-95 levels in the hippocampus. Conclusion: Interventions in environmental conditions can modulate the outcomes of long-term cognitive consequences associated with sepsis, supporting the idea of ​​the potential benefits of EE.
A City as a Source of Introduction for Tropical Alien Species (Egeria Densa Planch., Pistia Stratiotes L. &amp; Eichornia Crassipes (Mart.) Solms) in Natural Ecosystems with a Temperate Climate
Authors: Prokopuk Mariana , Zub Lesya , Bereznichenko Yuliia 
Published: December 2021

Abstract
This paper is concerned with the study of ecology and invasive behaviour of southern tropical invaders (Egeria densa, Pistia stratiotes, Eichornia crassipes) in the setting of urban landscape water bodies with a temperate climate (the case of Kyiv, Ukraine). The article explores the role of a city as a source of invasions. It shows that escape from aquaculture (aquariums or decorative ponds) or deliberate release into natural water bodies are the main settlement solution. A brief historical background of these species found in water bodies of Ukraine has been presented. Favourable treatment for modern invasions of pantropical species has been analysed. Phytocoenotic special aspects of the communities formed by these species and ways and possibilities of naturalization of species in natural water bodies have been explored. Production indicators are being analysed.
Interactions Between Folate Intake and Genetic Predictors of Gene Expression Levels Associated with Colorectal Cancer Risk
Authors: Haas Cameron B. , Su Yu-Ru , Petersen Paneen , Wang Xiaoliang , Bien Stephanie A , Lin Yi , Albanes Demetrius , Weinstein Stephanie J , Jenkins Mark A , Figueiredo Jane C , Newcomb Polly A , Casey Graham , Marchand Loic Le , Campbell Peter T , Peters Ulrike , Hsu Li , Moreno Victor , Potter John D , Sakoda Lori C , Slattery Martha L , Chan Andrew T , Li Li , Giles Graham G , Milne Roger L , Gruber Stephen B , Rennert Gad , Woods Michael O , Gallinger Steven J , Berndt Sonja , Hayes Richard B , Huang Wen-Yi , Wolk Alicja , White Emily , Nan Hongmei , Nassir Rami , Lindor Noralane M , Lewinger Juan P , Kim Andrew E , Conti David , Gauderman W. James , Buchanan Daniel D 
Published: December 2021

Abstract
Background

Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elucidate the underlying mechanism. Aggregating functionally relevant genetic variants in set-based variant testing has higher power to detect gene-environment (GxE) interactions and may provide information on the underlying biological pathway.
Objective

We investigated interactions between folate consumption and predicted gene expression on colorectal cancer risk across the genome.
Methods

We used variant weights from the PrediXcan models of colon tissue-specific gene expression as a priori variant information for a set-based GxE approach. We harmonized total folate intake (mcg/day) based on dietary intake and supplemental use across cohort and case-control studies and calculated sex and study specific quantiles. Analyses were performed using a mixed effects score tests for interactions between folate and genetically predicted expression of 4,839 genes with available genetically predicted expression. We meta-analyzed results across 23 studies for a total of 13,498 cases with colorectal tumors and 13,918 controls of European ancestry.
Results

We found suggestive evidence of interaction with folate intake for genes including glutathione S-Transferase Alpha 1 (GSTA1; p=4.3E-4), Tonsuko Like, DNA Repair Protein (TONSL; p=4.3E-4), and Aspartylglucosaminidase (AGA: p=4.5E-4). Glutathione is an antioxidant, preventing cellular damage and is a downstream metabolite of homocysteine and metabolized by GSTA1. TONSL is part of a complex that functions in the recovery of double strand breaks and AGA plays a role in lysosomal breakdown of glycoprotein.
Conclusion

We identified three genes involved in preventing or repairing DNA damage that may interact with folate consumption to alter CRC risk.
Theoretical Solutions to The Problem of Seepage and Consolidation in Saturated Clay Based on The Spatial Axisymmetric Model
Authors: Gao Zi-kun , Wang Jing-guo 
Published: December 2021

Abstract
The series solutions to the problem of spatial axisymmetric consolidation are deduced under non-homogeneous boundary conditions. Firstly, differentiable step function is introduced to construct the homogeneous operation function. Secondly, the operation function is used to superimpose the non-homogeneous boundaries to obtain homogeneous boundaries, non-homogeneous fundamental equation and new initial condition. Finally, the method of variables separation is used to construct the eigenfunction, and due to the mathematical justification of complete orthogonality of the eigenfunction, the series expansions of the fundamental equation and initial condition are carried out to obtain solutions for the seepage and consolidation in saturated clay with a borehole boundary. The correctness of the theoretical solutions are verified by the strict mathematical and mechanics derivation and the law of space-time variation in seepage flow.