bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Enhancing of Galloping-based Piezoelectric Energy Harvesting by Exploiting 1:1 Internal Resonance of Magnetically Coupled Oscillators
Authors: Sun Wan , Guo Canzhi , Cheng Guanggui , He Shangwen , yang zhaorui , Ding Jianning 
Published: November 2021

Abstract
In this study, we introduced 1:1 internal resonance in a magnetically coupled 2-degree-of-freedom (2-DOF) galloping-based piezoelectric energy harvester to improve the energy harvesting efficiency. The governing equations for the proposed magnetically coupled aero-electro-mechanical system considering the effect of oscillating wake are established using the extended Hamilton principle, and the method of multiple scale is exploited to obtain approximate analytical solutions. Parameter sweeping numerical calculation is conducted to validate the analytical prediction through comparing with analytical solutions, and the results show a good matching between them. In addition, we investigated the systematic dynamic behaviors under a pure oscillating wake induced 1:1 internal response. Typical nonlinear characteristics such as jump, hysteresis, frequency synchronization under varying design parameters appear in the present system. Especially, cusp bifurcation and synchronization regime of oscillating wake coupled nonlinear oscillator in \(\eta - {\Theta _w}\) plane and \(\sigma - {\Theta _w}\) plan. With an adoption of magnetic force, chaos happens as the gap distance decreases smaller than 5 mm, and a frequency lock-in phenomenon can be strengthened through adjusting the magnet distance. In the perspective of output performance, both of the voltage and power output results shows that the exploiting of 1:1 internal resonance can significantly improve the output performance under a suitable magnet distance.
Analysis of the Psychological States of the Scientific Expeditioners in Extreme Environment
Authors: Wang Jiayi , Li Haibin , Qu Lihong , WANG Tao , GAN Di , Liu Ye , Liu Wenjuan , Ji Jianlin 
Published: November 2021

Abstract
Background: To investigate the relationship among individuals’ mood, sleep and personality traits in a long-term polar environment.Methods: A total of 85 Arctic expedition team members were recruited in this study. In addition to personality assessment, they also completed assessments of anxiety, depression, and sleep at baseline, the second and eighth week. The rank sum test was used to compare the differences between mood and sleep at different time periods, and the generalized linear mixed model was used to explore the relations between personality and mood, as well as sleep.Results: The PHQ-9 scores showed a statistically significant difference between baseline and week 8. The PSQI scores showed a significant difference between baseline and week 2. At the same time, there was a significant difference between those who are married and those being single. Single individuals scored significantly lower on GAD-7 than married ones. The relationship between personality traits and PHQ-9 scores was statistically significant and individuals’ coping styles have an impact on their subjective sleep quality, sleep disturbance and daytime dysfunction. Conclusion: In the polar environment, over time, people's mood and sleep will be affected, and that is related to individual characteristics, personality and coping styles.
Comparison of MLC Positioning Deviations Using Log Files and Establishment of Specific Assessment Parameters for Different Accelerators With IMRT and VMAT
Authors: Lin Xiutong , Sun Tao , Liu Xiao , Zhang Guifang , Yin Yong 
Published: November 2021

Abstract
Background and purpose: The study evaluated the differences in leaf positioning deviations by the log files of three advanced accelerators with two delivery techniques, and established specific assessment parameters of leaf positioning deviations for different types of accelerators.Methods: A total of 300 treatment plans with 5 consecutive treatment log files were collected from the Trilogy, TrueBeam and Halcyon accelerators. 50 IMRT and 50 VMAT plans were selected randomly on each accelerator. The log files information was parsed by SunCheck software from Sun Nuclear Corporation. The maximum leaf RMS errors, 95th percentile errors and percentages of different leaf positioning errors were statistically analyzed. The correlations between these evaluation parameters and accelerator performance parameters (maximum leaf speed, mean leaf speed, gantry and arc angle) were analyzed.Results: The average maximum leaf RMS errors of the Trilogy in the IMRT and VMAT plans were 0.45±0.1mm and 0.80±0.07mm, respectively, which were higher than the TrueBeam's 0.03±0.01mm, 0.03±0.01 mm and the Halcyon's 0.06±0.01 mm, 0.07±0.01mm. Similar data results were shown in the 95th percentile error. The maximum leaf RMS errors were strongly correlated with the 95th percentile errors. The leaf positioning deviations in VMAT were higher than those in IMRT for all accelerators. In TrueBeam and Halcyon, leaf position errors above 1 mm were not found in IMRT and VMAT plans. The main influencing factor of leaf positioning deviation was the leaf speed, which has no correlation with gantry and arc angles.Conclusions: Compared with the quality assurance guidelines, the MLC positioning deviations tolerances of the three accelerators should be tightened. For both IMRT and VMAT techniques, the 95th percentile error and the maximum RMS error are suggested to be tightened to 1.5 mm and 1 mm for the Trilogy accelerator respectively. In TrueBeam and Halcyon accelerators, the 95th percentile error and maximum RMS error of 1 mm and 0.5 mm, respectively, are considered appropriate.
Exploiting Type I-B CRISPR Genome Editing System in Thermoanaerobacterium Aotearoense SCUT27 And Engineering The Strain For High-Level Ethanol Production
Authors: Dai Kaiqun , Fu Hongxin , Guo Xiaolong , Qu Chunyun , Wang Jufang 
Published: November 2021

Abstract
Background: Thermophilic microbes for biofuels and chemicals have attracted great attention due to their tolerance of high temperature and wide range of substrate utilization. Thermoanaerobacterium aotearoense SCUT27 has the ability of glucose and xylose co-utilization in lignocellulosic biomass. Polygene manipulation was a bottleneck since it was hindered by available markers for selection. In this study, the endogenous Type I-B CRISPR/Cas system was developed for multiplex genome editing in SCUT27. Results: The protospacer-adjacent motif (PAM) was identified by in silico and orotidine-5’-phosphate decarboxylase (pyrF) and then lactate dehydrogenase (ldh) were chosen as the editing target to assess the toxicity of this immune system and gene editing efficiency. The mutants could be repeatedly obtained with an editing efficiency of 58.3-100%. Higher transformation efficiency was observed after optimization of some editing strategies. Furthermore, a new method was performed for screening mutants of plasmid curing (recycling of the editing plasmid) for multiplex genome editing based on the negative selection marker tdk, and then ldh and arginine repressor (argR) were knocked out successively. The mutant SCUT27/Δldh/ΔargR had the prominent advantages over SCUT27 for ethanol production with enhanced ability to metabolize xylose. When cultured under various lignocellulosic hydrolysates, the mutant showed a satisfactory performance with the ethanol titer and yield improved by 147.42–739.40% and 112.67–267.89%, respectively, compared with SCUT27, as well as the enhanced tolerance to inhibitors.Conclusion: The multi-gene editing by native CRISPR/Cas system is a promising strategy to engineer SCUT27 for higher ethanol production with lignocellulosic hydrolysates.
QKI Promotes Hypoxia Induced Smooth Muscle Reprogramming in Pulmonary Hypertension
Authors: Huang Huijie , Lin Donghai , Hu Li , Wang Jie , Yu Yanfang , Yu Youjia , Li Kai , Chen Feng 
Published: November 2021

Abstract
Background: Pulmonary hypertension (PH) is a complex and progressive cardiopulmonary disorder with poor prognosis and limited therapeutic treatments. Recent evidence suggests that RNA binding proteins (RBPs) participate in the pathogenesis of human and experimental pulmonary arterial hypertension. Quaking (QKI) as an important RBPs is involved in mRNA biogenesis, export, decay and translation. However, the biological significance of QKI in phenotypic transformation of PASMCs in PH as well as in abnormal pulmonary vascular remodeling remain elusive. Methods: We assessed the expression pattern, phenotypic transformation effect, and mechanism of QKI in rodent Su/Hx-induced PH model, Human PAH samples and in HPASMCs.Results: Elevated protein expression level of QKI was found in animal PH and human PAH samples, thus in hypoxic HPASMCs. Inhibition of QKI attenuated proliferation and phenotype switching in HPASMCs. Mechanistically, QKI was found to mediate STAT3 mRNA stabilization by binding to its 3’Untranslated Region (3’-UTR). Downregulation of QKI attenuated STAT3 expression in PASMCs, while overexpression of STAT3 in PASMCs was widely regarded to be involved in the progression of PH. In addition, as a transcription factor, STAT3 was identified to bound to miR-146b promoter to induce its expression, while miR-146b was proved to promote smooth muscle reprogramming through inhibiting STAT1 and TET2 expression during pulmonary vascular remodeling.Conclusions: Our study demonstrates the QKI-STAT3-miR-146b pathway as a novel mechanistic insights into hypoxic reprogramming that permits vascular remodeling, and thus provides proof of concept for anti-remodeling therapy through the direct modulation this axis in PH.
Novel Absolute Rotary Position Sensor Based on Combination of Gray Scale Pattern Disc
Authors: Choe Ji Myong , Yu Nam Chol , Ri Nam Jin , An Mu Song , Kim Un Chol 
Published: November 2021

Abstract
Absolute rotary angular /position sensors play an important role in various applications and rapid development of new technologies requires further accurate measurement and control. In this paper, a novel, very simple, low-cost and high accurate absolute rotary angular/ position sensor is presented. The sensor operation is based on the combination of circular gradient gray scale and gray code pattern. A simple experiment is done in order to demonstrate proof of concept of proposed sensor. The experimental results show that the proposed absolute rotary angular/position sensor has excellent linear characteristics with accuracy below ±1° and resolution of 0.1° within the full measurement range from 0° to 360°. The proposed idea and experimental results can be helpful to design absolute rotary angular/position sensor to improve performance of it.
The Impact of the Surgical Apgar Score On Oncological Outcomes in Patients With Colorectal Cancer: A Single-Center Retrospective Cohort Study
Authors: Sugimoto Atsushi , Fukuoka Tatsunari , Nagahara Hisashi , Shibutani Masatsune , Iseki Yasuhito , Sasaki Maho , Okazaki Yuki , Maeda Kiyoshi , Ohira Masaichi 
Published: November 2021

Abstract
Background: The surgical Apgar score (SAS) predicts postoperative complications (POCs) following gastrointestinal cancer surgery. Recently, the SAS was reported to be a predictor of not only POCs but also the prognosis. However, the impact of the SAS on oncological outcomes in patients with colorectal cancer (CRC) has not been fully examined. The present study therefore explored the oncological significance of the SAS in patients with CRC.Methods: We retrospectively analyzed 639 patients who underwent radical surgery for CRC. The SAS was calculated based on three intraoperative parameters: estimated blood loss, lowest mean arterial pressure and lowest heart rate. The optimal cut-off value of the SAS was determined by receiver operating characteristic curves. All patients were classified into 2 groups based on the SAS (≤6 and >6). The association of the SAS with the recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) was analyzed.Results: Univariate analyses revealed that a lower SAS (≤6) was significantly associated with a worse RFS, OS and CSS. A multivariate analysis revealed that age ≥75 years old, Charlson comorbidity index ≥1, ASA-Physical Status ≥3, SAS ≤6, histologically undifferentiated tumor type and an advanced pStage were independent factors for the OS, and an SAS ≤6 and advanced pStage were independent factors for the CSS.Conclusions: A lower SAS (≤6) was an independent prognostic factor for not only the OS but also the CSS in patients with CRC, suggesting that the SAS might be a useful biomarker predicting oncological outcomes in patients with CRC.
A mantle-source solution to the enigma of bimodal arc volcanism
Authors: Daczko Nathan , Chapman Timothy , Foerster Michael , Handley Heather , Foley Stephen 
Published: November 2021

Abstract
Silicate melts in arc environments are dominated by mafic (low-silica) and silicic (high-silica) compositions, often generating a characteristic bimodal pattern. We investigate the whole arc crust and show that the plutonic lower crust shares the bimodal pattern of melts from volcanoes. This key observation reveals that, contrary to some explanations of bimodal volcanism, variation in mantle source and mantle processes must fundamentally control bimodalism. We also recognise bimodalism in Th/La composition of the whole arc crust and suggest a new working hypothesis: bimodalism originates by melting of distinct sub-arc mantle sources, one dominated by relatively dry peridotite and the other by hydrous pyroxenite. The two groups of primary melts fractionate along distinct liquid lines of descent that lead to relatively dry mafic melts (Th/La~0.1) versus hydrous silicic melts (Th/La>0.2) by 65–80% fractional crystallisation. Common crustal processes such as crystal fractionation, assimilation, reactive flow and/or magma mixing may also lead to differentiation of both groups.
Big Data-oriented Wheel Position and Geometry Calculation for Cutting Tool Groove Manufacturing based on AI Algorithms
Authors: Guochao Li , Liu Zhigang , Lu Jie , Zhou Honggen , Sun Li 
Published: November 2021

Abstract
Groove is a key structure of high-performance integral cutting tools. It has to be manufactured by 5-axis grinding machine due to its complex spatial geometry and hard materials. The crucial manufacturing parameters (CMP) are grinding wheel positions and geometries. However, it is a challenging problem to solve the CMP for the designed groove. The traditional trial-and-error or analytical methods have defects such as time-consuming, limited-applying and low accuracy. In this study, the problem is translated into a multiple output regression model of groove manufacture (MORGM) based on the big data technology and AI algorithms. The input are 34 groove geometry features and the output are 5 CMP. Firstly, two groove machining big data sets with different range are established, each of which is includes 46656 records. They are used as data resource for MORGM. Secondly, 7 AI algorithms, including linear regression, k nearest-neighbor regression, decision trees, random forest regression, support vector regression and ANN algorithms are discussed to build the model. Then, 28 experiments are carried out to test the big data set and algorithms. Finally, the best MORGM is built by ANN algorithm and the big data set with a larger range. The results show that CMP can be calculated accurately and conveniently by the built MORGM.
KIF3A Inhibits NPC Proliferation, Migration and Invasion By Interacting With β-Catenin To Suppress Its Nuclear Accumulation
Authors: Hu Zhe , Meng Jinlan , Cai Hongbing , Ma Na , Gao Xiujie , Li Xiaojuan , Xu Yan 
Published: November 2021

Abstract
Background
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumour that is prevalent in Southern China and other Southeast Asian countries. In previous studies, Kinesin Family Member 3A (KIF3A) was shown to play a dual role in cancers. However, the biological role of KIF3A in NPC and the underlying mechanism have not been reported.
Methods
The KIF3A mRNA and protein expressions in NPC were analyzed by qRT-PCR (Quantitative real-time polymerase chain reaction), Western blotting and immunohistochemistry. CCK-8, EDU incorporation assay, Colony formation, cell cycle assay, Wound-Healing Assay, Transwell verified KIF3A regulates the proliferation, migration, invasion of NPC cells. The in vivo effect of KIF3A on proliferation was elucidated with a xenograft mouse model. COIP (Co-immunoprecipitation) assay showed KIF3A interacts with β-catenin. Confocal microscopy colocalization assay confirmed colocalization of KIF3A and β-catenin in NPC cells. Nuclear and cytoplasmic extraction assays were performed to analyze the distribution of β-catenin in the nuclei and cytoplasm.
Results
In this study, we found that KIF3A interacts with β-catenin, suppressing the intranuclear aggregation of β-catenin, then inactivating the Wnt/β-catenin signaling pathway as well as the downstream cell cycle factors and EMT signal to inhibit NPC proliferation, migration, and invasion.
Conclusions
These findings suggest that KIF3A interacts with β-catenin and attenuates the malignant progression of NPC by inhibiting β-catenin intranuclear aggregation. KIF3A may be a promising therapeutic target for NPC patients.
Effects of Abdominal Aortic Calcification and Facet Joint Arthritis On Lumbar Bone Mineral Density Using Dual-Energy X-Ray Absorptiometry
Authors: Cho Minjoon , Kim Hong Seok , Choi Byung Sun , Lee Jae Hyup 
Published: November 2021

Abstract
Background Abdominal aortic calcification (AAC) may overestimate lumbar bone mineral density (BMD) examined by dual-energy X-ray absorptiometry (DXA); however, the degree of effect of AAC on lumbar BMD has not been quantified. In particular, no study has quantitatively compared and analysed segmental BMD and AAC using computed tomography (CT) scan. Thus, this study aimed to quantify the effect of AAC on BMD measurements using DXA via multiple linear regression analysis. Methods This study retrospectively reviewed participants >30 years of age who underwent DXA and spinal CT scans between 2014 and 2016. Variables that significantly affected the BMD of each lumbar segment were identified. Additionally, segmental facet joint arthritis (FJA) and AAC volume were evaluated using CT. Results A total of 620 subjects (153 males and 467 females) were included. The mean age was 71.6 ± 9.1 years (range, 31–89 years). AAC had the highest prevalence in L3 (45.2%), followed by L4 (41.1%). The average volume of AAC was the highest in L4 at 213.67 ± 443.82 mm3, followed by L3 at 161.95 ± 338.09 mm3. Our regression model found that Ln (L4BMD) was significantly correlated with age, BMI, FJA, and AAC volume in female subjects. Additionally, L4 BMD might be overestimated by approximately 0.90% for every 100 mm3 increase in AAC volume. The results for Ln (L3BMD) were almost identical. However, these relationships were not observed in males. Conclusion According to this model, AAC may overestimate lumbar BMD examined by DXA in a dose-dependent manner in females.
Psychometrics of The Physical Health Attitude Scale in Taiwanese Mental Health Nurses: A Validation Study Authors’ Full Names
Authors: Tzeng Wen-Chii , Feng Hsin-Pei , Lin Chia-Huei , Chang Yue-Cune , Haddad Mark 
Published: November 2021

Abstract
Background
The Physical Health Attitude Scale (PHASe) is a reliable and valid scale for assessing mental health nurses’ attitude towards providing physical healthcare to patients diagnosed with serious mental illness.
Aims
To psychometrically evaluate the Chinese adaptation of the PHASe.
Methods
A total of 520 mental health nurses from 11 hospitals across Taiwan participated in this study. Brislin’s translation model was utilized for the validation process. Both exploratory factor analysis and confirmatory factor analysis were used to establish the construct validity of the scale, and Cronbach’s alpha and composite reliability were used to determine reliability.
Results
The four-factor 17-item Chinese version of the PHASe demonstrated satisfactory fit with significant factor loadings. Each factor had adequate internal consistency (Cronbach's alpha = 0.70 to 0.80). Known-group validity was supported by the significant differences between groups with different attitudes.
Conclusions
Our findings suggest that the Chinese version of PHASe is acceptable for evaluating nurses’ attitude towards providing physical health care both within culturally Chinese societies and in cross-cultural studies.
Modification of Magnetic Graphene Oxide By An Earth-Friendly Deep Eutectic Solvent To Preconcentrate Ultratrace Amounts Pb(II) In Oil Seeds
Authors: Khah Melika Hejazi , Jamshidi Parastoo 
Published: November 2021

Abstract
The aim of this article is presenting an earth-friendly deep eutectic solvent (DES) to preconcentrate ultratrace amounts of Pb(II) prior to its quantification by flame atomic adsorption spectroscopy. The synthesis of adsorbent started by preparing graphene oxide according to the modified Hammer’s method, followed by magnetization by Fe3O4 nanohemispheres. Magnetic graphene oxide was dispersed in a mixture of LiCl and urea at 60° via ultrasonication. All the materials are environmentally-friendly and the preparation strategy is energy efficient. X-ray diffraction, scanning electron microscopy, alternating gradient force magnetometer and Fourier-transform infrared spectroscopy were applied to characterize the products. Graphene oxide has a large surface area and could be functionalized with DESs through π-π interaction and electrostatic force. Urea has active negative sites, which garb heavy metals due to the interaction between negative and positive agents. Accordingly, this adsorbent (UreaLiCl-mGO) could be offered as a capable adsorbent to preconcentrate ultratrace amounts of Pb(II). Conditions were optimized, and under the optimum situation, (a) limit of detection of 99 × 10-8 g L-1, (b) relative standard deviation (n=5) of 1.3%, (c) preconcentration factor of 100 (d) linearity of dynamic range of 5.0 × 10-6 – 23 × 10-6 g L-1, (e) durability of 6 months and (f) reusability of 7 times prove applicability of the adsorbent. The tests of selectivity, effect of interference ions, swelling property, isotherm of adsorption, kinetic of adsorption and thermodynamic of adsorption were completely investigated. Four different oil seeds were successfully applied as real samples.