bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Analysis of a Novel Eleven-Small Nucleolar RNA Prognostic Signature in Patients With Lower Grade Glioma
Authors: Deng Teng , Gong Yizhen , Liao Xiwen , Wang Xiangkun , Zhou Xin , Zhu Guangzhi , Mo Ligen 
Published: June 2021

ObjectiveThe present study used the RNA sequencing (RNA-seq) dataset to identify prognostic snoRNAs and construct a prognostic signature of The Cancer Genome Atla (TCGA) lower grade glioma (LGG) cohort, and comprehensive analysis of this signature.MethodsRNA-seq dataset of 488 patients from TCGA LGG cohort were included in this study. Comprehensive analysis including function enrichment, gene set enrichment analysis (GSEA), immune infiltration, cancer immune microenvironment, and connectivity map (CMap) were used to evaluate the snoRNAs prognostic signature.ResultsWe identified 21 LGG prognostic snoRNAs and constructed a novel eleven-snoRNA prognostic signature for LGG patients. Survival analysis suggests that this signature is an independent prognostic risk factor for LGG, and the prognosis of LGG patients with a high-risk phenotype is poor (adjusted P = 0.003, adjusted hazard ratio = 2.076, 95% confidence interval = 1.290–3.340). GSEA and functional enrichment analysis suggest that this signature may be involved in the following biological processes and signaling pathways: such as cell cycle, Wnt, mitogen-activated protein kinase, janus kinase/signal transducer and activator of tran-ions, T cell receptor, nuclear factor-kappa B signaling pathway. CMap analysis screened out ten targeted therapy drugs for this signature: 15-delta prostaglandin J2, MG-262, vorinostat, 5155877, puromycin, anisomycin, withaferin A, ciclopirox, chloropyrazine and megestrol. We also found that high- and low-risk score phenotypes of LGG patients have significant differences in immune infiltration and cancer immune microenvironment.ConclusionsThe present study identified a novel eleven-snoRNA prognostic signature of LGG and performed a integrative analysis of its molecular mechanisms and relationship with tumor immunity.
Analysis of Applicator Insertion Related Acute Side Effects for Cervical Cancer Treated With Brachytherapy
Authors: Chen Jiajun , Zhang Ning , Liu Ying , Han Dongmei , Mao Zhuang , Yang Wei , Cheng Guanghui 
Published: June 2021

PurposeTo report applicator insertion-related acute side effects during brachytherapy (BT) procedure for cervical cancer patients.Materials and MethodsBetween November 2017 and December 2019, 407 BT fractions were performed in 125 patients with locally advanced cervical cancer. Acute side effects recorded comprised anesthesia-related side effects, mechanical-related side effects and infection, whose frequency and degree were recorded. Pain was assessed using numeric rating scale; vaginal bleeding volume was counted by weighing gauze pieces used in packing. The BT procedure comprised eight stages: anesthesia, applicator insertion, image acquisition, transport, waiting for treatment, dose delivery, applicator removal, and removed which denoted 0.5–12.0 h period after removal, with time of each stage recorded. Factors influencing acute side effects were assessed by Spearman correlation and Mann–Whitney U test.ResultsThe most common acute side effect was pain, followed by vaginal bleeding. The mean scores for pain were highest during removal time, 4.9 ± 1.6 points. The mean vaginal bleeding volume was 44.4 ml during removal time. Mean total procedure time was 218.8 (175–336) min, having positive relationship with frequency of acute side effects. The total procedure time with acute side effects was longer than that without acute side effects. The longest procedure time was waiting time, 113.0 (91.0–132.0) min. More needles generated higher pain scores and larger volume of vaginal bleeding.ConclusionPain and vaginal bleeding were the most common acute side effects, especially during removal time, which physicians should focus on. Shortening patients’ waiting time helps to reduce the total procedure time, thus, reduce acute side effects. While meeting dose requirement, less needles are helpful to reduce acute side effects.
Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer
Authors: Spreafico Filippo , Barretta Francesco , Murelli Michele , Chisari Marco , Gattuso Giovanna , Terenziani Monica , Ferrari Andrea , Veneroni Laura , Meazza Cristina , Massimino Maura 
Published: June 2021

Background: Cancer and its treatment can cause serious health issues that impair physical and mental well-being in children and adolescents. Exercise may be a valid strategy for managing some symptoms, including fatigue. In the light of our experience, we provide further justification for including exercise as part of routine childhood cancer care.Methods: Forty-four children and adolescents who had solid cancers not contraindicating their movement were invited to join an in-hospital 6-week supervised exercise program, and asked afterwards to complete validated quality of life and fatigue scales. The program consisted of personalized workout sessions of aerobic, resistance and flexibility exercises. The results obtained on the scales were compared between 21 patients who engaged in the exercise program (GYM group) and 23 who refused (No-GYM group), examining the different dimensions of health-related quality of life (physical, emotional, cognitive, social) and fatigue (general, sleep/rest, cognitive) in the two groups.Results: Being diagnosed with cancer initially prompted all but one of the respondents to drop-out of previous routine exercise or sports although their continuation had not been contraindicated. After 6 weeks of exercise, the GYM group's scores for quality of life and fatigue showed a statistically significant better perceived emotional functioning, and a trend toward a better social functioning than in the No-GYM group.Conclusion: We suggest that exercise improves the satisfaction of children and adolescents with cancer with their physical, mental and social functioning. We would emphasize the potential benefits of general practitioners discussing and recommending exercise for their young patients with cancer.
Cefdinir and β-Lactamase Inhibitor Independent Efficacy Against Mycobacterium tuberculosis
Authors: Srivastava Shashikant , Thomas Tania , Howe Dave , Malinga Lesibana , Raj Prithvi , Alffenaar Jan-Willem , Gumbo Tawanda 
Published: June 2021

Background: There is renewed interest in repurposing β-lactam antibiotics for treatment of tuberculosis (TB). We investigated efficacy of cefdinir, that withstand the β-lactamase enzyme present in many bacteria, against drug-susceptible and multi-drug resistant (MDR) Mycobacterium tuberculosis (Mtb).Methods: Minimum inhibitory concentration (MIC) experiments were performed with Mtb H37Ra, eight drug-susceptible, and 12 MDR-TB clinical isolates with and without the β-lactamase inhibitor, avibactam at 15 mg/L final concentration. Next, we performed dose-response study with Mtb H37Ra in test-tubes followed by a sterilizing activity study in the pre-clinical hollow fiber model of tuberculosis (HFS-TB) study using an MDR-TB clinical strain. Inhibitory sigmoid Emax model was used to describe the relationship between the drug exposure and bacterial burden.Results: Cefdinir MIC for Mtb H37Ra was 4 and 2 mg/L with or without avibactam, respectively. The MIC of the clinical strains ranged between 0.5 and 16 mg/L. In the test-tube experiments, cefdinir killed 4.93 + 0.07 log10 CFU/ml Mtb H37Ra in 7 days. In the HFS-TB studies, cefdinir showed dose-dependent killing of MDR-TB, without combination of avibactam. The cefdinir PK/PD index linked to the Mtb sterilizing efficacy was identified as the ratio of area under the concentration-time curve to MIC (AUC0–24/MIC) and optimal exposure was calculated as AUC0–24/MIC of 578.86. There was no resistance emergence to cefdinir in the HFS-TB.Conclusion: In the HFS-TB model, cefdinir showed efficacy against both drug susceptible and MDR-TB without combination of β-lactamase inhibitor. However, clinical validation of these findings remains to be determined.
Structural Health Monitoring Method of Pantograph–Catenary System Based on Strain Response Inversion
Authors: Liu Sheng , Wei Yibo , Yin Yongxin , Feng Tangzheng , Lin Jinbao 
Published: June 2021

Pantograph-catenary system provides electric energy for the subway lines; its health status is essential to the serviceability of the vehicle. In this study, a real-time structural health monitoring method based on strain response inversion is proposed to calculate the magnitude and position of the dynamic contact force between the catenary and pantograph. The measurement principle, calibration, and installation detail of the fiber Bragg grating (FBG) sensors are also presented in this article. Putting this monitoring system in use, an application example of a subway with a rigid overhead catenary is given to demonstrate its performance. The pantograph was monitored and analyzed, running underground at a maximum speed of 80 km/h. The results show that the strain response inversion method has high measurement accuracy, good data consistency, and flexibility on sensor installation. It can accurately calculate the magnitude and location of the contact force exerted on the pantograph.
Factors Associated With Mental Health Symptoms During the COVID-19 Pandemic in Hong Kong
Authors: Zhao Sheng Zhi , Luk Tzu Tsun , Wu Yongda , Weng Xue , Wong Janet Yuen Ha , Wang Man Ping , Lam Tai Hing 
Published: June 2021

Background: The COVID-19 pandemic has led to an increasing mental health burden. We examined the factors associated with mental health symptoms in Chinese general adults in Hong Kong.Methods: We conducted a dual-frame (landline and mobile) survey on Chinese adults aged 18 years or older in April 2020. Shortage of preventive materials, perceptions of the outbreak (each item range 1–5), and reduction in income were assessed. Mental health symptoms measured included stress (Perceived Stress Scale-4, range 0–16), anxiety (General Anxiety Disorders-2, range 0–6, cutoff &gt;2), and depressive symptoms (Patient Health Questionnaire-2, range 0–6, cutoff &gt;2). Results were weighted by the general population distribution. Associations were analyzed by multivariable linear (for stress) and logistic (for anxiety and depressive symptoms) regression adjusting for sociodemographic and health-related covariates, including confirmed or in close contacts of confirmed cases, chronic disease, self-rated health, and smoking and alcohol drinking behavior.Results: Of the 1,501 participants (52.5% female, 55.0 aged 30–59 years), the average stress score was 7.20 (SD 2.12). 218 (15.8%) and 206 (14.8%) participants had anxiety and depressive symptoms, respectively. Shortage in facemasks (20.8%), alcohol-based hand sanitizers (13.9%), and cleaning products (7.3%) was reported. Participants generally disagree with the perception of at risk of getting infected in the coming 6 months (mean 2.2, SD 1.1), but tended to agree with the perception of worry that the people around pose a threat to them (mean 3.6, SD 0.9) and the outbreak has greatly affected their daily life (mean 3.7, SD 0.9). 59.3% employed participants had income reduction and 6.2% had become unemployed since the outbreak. Stress, anxiety, and depressive symptoms were more prevalent in those with shortages of preventive materials and negative perceptions of the outbreak (all P &lt; 0.05). Reduction in income and unemployment were associated with more mental health symptoms (all P &lt; 0.05).Conclusions: Shortage of preventive materials, negative perceptions, financial loss, and unemployment were prevalent during the outbreak and found in association with higher stress and more anxiety and depressive symptoms. Further research and urgent actions are warranted to relieve stress and promote mental health, targeting the many risk factors identified by our study.
Knowledge, Attitude, and Willingness Toward Kidney Donation Among Health Sciences Students at King Saud Bin Abdulaziz University
Authors: Sharaan Raghad , Alsulami Sara , Arab Raneem , Alzeair Ghida , Elamin Nadia , Alsaywid Basim , Lytras Miltiadis 
Published: June 2021

Background: End-stage renal disease, as one of the most serious and major health problems, does not have many treatment options available. One of the best treatment modalities used to cure this debilitating disease is kidney transplantation. However, with the continuous increase in number of patients diagnosed with it, there is not enough supply of the organ. The aim of our study is to assess knowledge about, attitude toward, and willingness to donate kidney among health science students at King Saud bin Abdulaziz University in comparison to the general population in Jeddah and to investigate the factors that play a role on their willingness.Methods: This is an observational, analytical, cross-sectional study design conducted in 2019. Two target populations were included: King Saud bin Abdulaziz University for Health Sciences students and the general population in Jeddah. Data were collected via a self-administered, close-ended, structured, and previously validated questionnaire that contained 39 items divided into four sections. SPSS program version 22 was used in data analysis.Results: Out of 685 surveyed participants, 179 (26.1%) were willing to donate their kidney, with students showing a higher rate of willingness (N = 101; 32.3%) than the general population (N = 78; 21%). However, only 46 (6.7%) out of the total population hold an organ donor card. In bivariate analysis, it was found that knowledge significantly associated with a higher rate of willingness among the student population than the general population, while positive beliefs were associated with increased willingness in the general population than students. Positive attitude appeared to play a role in higher willingness among the general population and student population.Conclusion: There is a low perception of awareness regarding kidney donation in both populations of this study. The willingness rate of health science students at King Saud bin Abdulaziz University and the general population was low when compared with other studies conducted internationally.
A Novel Electricity and Freshwater Production System: Performance Analysis from Reliability and Exergoeconomic Viewpoints with Multi-Objective Optimization
Authors: Hamrang Farzad , Mahmoudi S. M. Seyed , Rosen Marc A. 
Published: June 2021

Based on the benefits of integrated gasification combined cycles (IGCCs), a cogeneration plant for providing electricity and freshwater is proposed. The main novelties of the devised system are the integration of biomass gasification and a regenerative gas turbine with intercooling and a syngas combustor, where the syngas produced in the gasifier is burned in the combustion chamber and fed to a gas turbine directly. The energy discharged from the gas turbine is utilized for further electricity and freshwater generation via Kalina and MED hybridization. The proposed system is analyzed from energy, exergy, exergoeconomic, and reliability–availability viewpoints. The optimal operating condition and optimum performance criteria are obtained by hybridizing an artificial neural network (ANN), the multi-objective particle swarm optimization (MOPSO) algorithm. According to results obtained, for the fourth scenario of the optimization process, optimal values of 45.10%, 14.27 kg·s−1, 12.95 USD·GJ−1, and 8141 kW are obtained for the exergy efficiency, freshwater production rate, sum unit cost of products, and net output power, respectively. According to reliability and availability assessment, the probability of the healthy working state of all components and subsystems is 88.4403%; the system is shown to be 87.74% available of the time over the 20-year lifetime.
Sistem Pengolahan Data Log Quality Control System Paper Machine Menjadi Informasi Paper Profile
Authors: Kustiawan Wawan , Darmansyah Darmansyah 
Published: June 2021

Sistem QCS (Quality Control System) bisa memonitor kualitas kertas secara in-line saat proses produksi. Sistem QCS dapat mengeluarkan data kualitas kertas dalam bentuk log file teks. Data pada log file teks dapat diolah dan dianalisa untuk menjadi informasi kualitas kertas dengan parameter-parameter yang terdiri dari : basis weight (gramature), ash titrasi, moisture content, opasitas dan porositas. Informasi kualitas kertas ini disebut informasi paper profile. Sistem Pengolahan Data Log QCS Menjadi Informasi Paper Profile pada penelitian ini dikembangkan dengan menggunakan metodologi prototyping dan bahasa pemrograman Visual Basic .Net. Pengolahan data pada sistem ini menggunakan metoda SPC (Statistical Process Control) dan memanfaatkan fasilitas-fasilitas yang dimiliki oleh Microsoft Excel yaitu pemrograman VBA, fungsi-fungsi statistik dan kemampuan membuat tampilan grafis yang menarik dan sudah sangat dikenal oleh pengguna komputer. Sistem informasi paper profile akan menyimpan dan mendistribusikan informasi paper profile melalui sebuah aplikasi berbasis web kepada pihak-pihak yang berkepentingan. Sehingga informasi paper profile dapat dibuat dan didistribusikan dengan mudah dan cepat . Informasi paper profile ini diperlukan untuk mengetahui kualitas produk dan untuk memonitor kapabilitas proses dalam menghasilkan produk.
Analisa Dan Perancangan Website Sdn Karawang Kulon
Authors: Noviyanthi Erlina , Suhada Karya 
Published: June 2021

Ilmu pengetahuan dan teknologi informasi berkembang cukup pesat dan menghasilkan inovasi-inovasi baru yang senantiasa terus berubah ke arah yang lebih baik. Informasi menjadi kata kunci dalam berbagai aspek kehidupan. Siapa yang dapat menguasai informasi, baik penguasaan dalam proses penyajian, maupun mendapatkan, ia akan bisa tampil survive di tengah persaingan yang sedemikian ketat. Dengan alasan inilah perhatian terhadap proses informasi menjadi sangat di tekankan. Sistem Informasi Sekolah adalah suatu tatanan yang berhubungan dengan penyampaian informasi akan kebutuhan informasi sekolah dari berbagai pihak. Tujuan dari perancangan ini diharapkan dapat memberikan kemudahan bagi berbagai pihak dalam memperoleh informasi secara lebih cepat dan akurat.
Metodologi yang digunakan penulis dalam pembahasan ini adalah metode studi pustaka yang meliputi mengumpulkan, membaca dan mempelajari buku-buku yang menunjang materi pembuatan skripsi melalui buku-buku, serta artikel-artikel internet. Selain itu digunakan juga metode perancangan dan merancangan layar-layar tampilan yang akan dipakai dalam website yang dibangun, mengevaluasi sistem dengan cara di implementasikan. Sebagai rancangannya tool yang digunakan yaitu Macromedia Dreamweaver dan MySQL sebagai databasenya. Dengan demikian penulis berharap dengan adanya website ini, dapat meningkatkan pelayanan akan suatu informasi kepada seluruh pihak, baik saat ini maupun di masa yang akan datang. Dan benar-benar dapat bermanfaat bagi para guru, siswa maupun staf-staf yang bekerja.
Sistem Informasi Pelayanan Administrasi Kependudukan Desa (Sipakde) Berbasis Web Dengan Framework Codeigniter
Authors: Haris Jaka Abdul , Darmansyah Darmansyah , Apdian Donny , Elanda Anggi 
Published: June 2021

Desa Kamojing sebelumnya telah menggunakan sebuah sistem informasi dari pemerintah pusat yaitu Sistem Informasi Manajemen Desa selanjutnya disebut SIMADE, akan tetapi SIMADE tersebut sudah tidak dapat bekerja secara optimal karena mengharuskan mengambil data dari Sistem Informasi Administrasi Kependudukan versi 5 atau SIAK 5 yang dimiliki oleh Direktorat Jenderal Kependudukan dan Pencatatan Sipil atau disingkat DISDUKCAPIL, sedangkan saat ini SIAK 5 tidak bisa mengeluarkan database penduduk yang dibutuhkan sehingga SIMADE ini tidak dapat berjalan. Sementara ini untuk menunjang berbagai pekerjaan dalam pengelolaan data masyarakat, Desa Kamojing memanfaatkan sistem manual yaitu buku register untuk pencatatan dan semi manual dengan aplikasi Microsoft Word dan Microsoft Excel untuk pendataan kependudukan. Sistem tersebut masih memiliki kelemahan, buku register dalam pencatatannya selain bisa terjadi kesalahan penulisan yang berakibat tidak validnya data, buku bisa basah dan rusak yang berakibat nantinya akan kesulitan saat pencarian data atau proses rekap data, dalam pembuatan surat pun juga tidak efektif karena setiap pembuatan surat yang berulang. Peneliti termotivasi untuk melakukan penelitian dan membuat Sistem Informasi Pelayanan Administrasi Kependudukan Desa (SIPAKDe) Berbasis Web Dengan Framework Codeigniter. Sistem informasi ini merupakan pengembangan dari sistem yang sudah ada dan mampu membantu pekerjaan perangkat desa. Peneliti menggunakan metode analisis PIECES (Performance, Information, Economic, Control, Efficiency, Service), untuk melakukan penelitiannya.
Sistem Informasi Penyewaan Rumah Kontrakan Berbasis Web Dengan Menggunakan Metode Prototype
Authors: Siswidiyanto Siswidiyanto , Munif Ahmad , Wijayanti Diah , Haryadi Eko 
Published: June 2021

Penyewaan rumah kontrakan membutuhkan sekali adanya suatu sistem informasi, karena proses penyewaan kontrakan saat ini masih menggunakan cara manual, yaitu dengan mencari kontrakan secara langsung dan pemilik kontrakan hanya memasang selebaran kertas di jalan terdekat dengan kontrakan yang dimiliki, dengan cara tersebut kurang efektif dan efisien. Sistem informasi penyewaan kontrakan berbasis web diharapkan dapat meminimalisir waktu yang dibutukan untuk mendapatkan informasi tentang hal tersebut. Dimana penyewaan kontrakan akan sangat lebih hemat dan calon penyewa dapat mencari yang sesuai dengan keinginan, mulai dari lokasi, harga, dan fasilitas kontrakan, Selain itu penyewa kontrakan juga dipermudah dalam hal pemesanan dan mekanisme pembayarannya. Metode yang digunakan dalam pembuatan sistem informasi ini adalah dengan menggunakan model prototype, dimana alur dan tahapan yang digunakan meliputi mengidentifikasi pengguna dan mengembangkan prototype. Hasil dari penelitian ini adalah berupa sistem informasi penyewaan rumah kontrakan berbasis web yang diharapkan dapat memudahkan proses pengolahan data penyewa.
Analisis Tingkat Penerimaan Pengguna Ovo Di Arawang Menggunakan Pendekatan Technology Acceptance Model (TAM)
Authors: Lacky Billie Khowirantio , Malfiany Rini 
Published: June 2021

Penelitian ini bertujuan untuk mengetahui tingkat penerimaan dari aplikasi OVO yang sebagai dompet digital di karawang dengan pendekatan TAM (Technology Acceptance Model). Jenis penelitian yang digunakan adalah penelitian penjelasan dengan pendekatan kuantitatif. Metode yang digunakan menggunakan TAM dengan variabel penelitian kemudahan pengguna dan kegunaan pengguna. Populasi dalam penelitian ini adalah masyarakat Karawang yang menggunakan aplikasi OVO. Sampel yang digunakan dalam penelitian ini sebanyak 100 orang responden yang diambil dengan menggunakan teknik simple random sampling dan metode pengumpulan data menggunakan metode survei dan kuesioner dengan instrumen angket dan pengukuran menggunakan skala likert. Hasil penelitian menunjukkan penelitian ini menggambarkan bahwa tingkat penerimaan sebagai bagian dari perusahaan, mempunyai pengaruh terhadap pengguna aplikasi tersebut. Sehingga perusahaan OVO harus terus meningkatkan kualitas aplikasi nya supaya semakin banyak pengguna yang menggunakan aplikasi OVO.