bluuebunny/crossref_metadata_2025_split huggingface dataset:
Launching an Electronic Patient-Reported Outcomes Initiative in Real-Time Clinical Practice
Authors: Palos Guadalupe R , Suarez-Almazor Maria E 
Published: July 2021

AbstractPatient-reported outcomes play an essential role in improving care across the cancer continuum. This paper reports on the experience of a tertiary care center to standardize the use, collection, and reporting of patient-reported outcomes (PROs) in 10 disease-specific survivorship clinics. To minimize the burden of patients to complete surveys, an institutional committee with oversight on all patient surveys required an application be reviewed and approved before their distribution in a clinic. To begin collecting PROs, each clinic submitted an application tailored to its clinical operations, staffing, and scheduling characteristics. The dates for the submission of each application were staggered over a 2-year period, which contributed to a lack of uniformity in the project (ie, approval dates, start dates, collection and reporting of results). The delays were primarily due to the time and resources required to build the electronic version of the PRO survey into the institutional electronic medical record. To date, 6 of 10 survivorship clinics submitted applications, 5 were approved, and 4 launched the electronic MD Anderson Symptom Inventory (eMDASI) through the patient portal. Metrics collected between January 2019 and December 2020 for the thyroid, bone marrow transplant, genitourinary, and head and neck clinics indicated the numbers of eMDASIs sent to patients varied by clinic, with the lowest from the bone marrow transplant survivorship clinic (6) and the highest (746) in the thyroid Clinic. The total number of eMDASIs returned by the patients ranged from 2 (bone marrow transplant) to 429 (thyroid). Overall, patients’ return rates of the eMDASI ranged from 33.3% to 57.7%. Several strategies were implemented to increase the delivery, submission, and completion of eMDASIs. Our findings indicate the integration and implementation of PROs in survivorship clinics are achievable. Further work is needed to enhance the ePROs web-based process to adequately compare PROs across diverse cohorts of cancer survivors .
Intussusception after open Roux-en-Y gastric bypass managed with laparoscopic reduction
Authors: Marcoe Jeffrey P , Chau Wai Yip 
Published: July 2021

Abstract
Intussusception is a rare long-term complication following bariatric surgery. With unclear risk factors and a variable presentation, intussusception is often diagnosed in emergency departments on cross-sectional imaging. Due to the nature of the disease process, prompt involvement of a bariatric surgeon and operative intervention offers the best outcome. Here, we discuss two similar cases of jejunojejunal intussusception following open Roux-en-Y gastric bypass and abdominoplasty that were managed with operative reduction of the involved bowel.
The pentatricopeptide repeat protein EMP603 is required for the splicing of mitochondrialNad1intron 2 and seed development in maize
Authors: Fan Kaijian , Ren Zhenjing , Zhang Xiaofeng , Liu Yan , Fu Junjie , Qi Chunlai , Tatar Wurinile , Rasmusson Allan G , Wang Guoying , Liu Yunjun 
Published: July 2021

AbstractIntron splicing is an essential event in post-transcriptional RNA processing in plant mitochondria, which requires the participation of diverse nuclear-encoded splicing factors. However, it is presently unclear how these proteins cooperatively take part in the splicing of specific introns. In this study, we characterized a nuclear-encoded mitochondrial P-type pentatricopeptide repeat (PPR) protein named EMP603. This protein is essential for splicing of intron 2 in the Nad1 gene and interacts with the mitochondria-localized DEAD-box RNA helicase PMH2-5140, the RAD52-like proteins ODB1-0814 and ODB1-5061, and the CRM domain-containing protein Zm-mCSF1. Further study revealed that the N-terminal region of EMP603 interacts with the DEAD-box of PMH2-5140, the CRM domain of Zm-mCSF1, and OBD1-5061, but not with OBD1-0814, whereas the PPR domain of EMP603 can interact with ODB1-0814, ODB1-5061, and PMH2-5140, but not with Zm-mCSF1. Defects in EMP603 severely disrupt the assembly and activity of mitochondrial complex I, leading to impaired mitochondrial function, and delayed seed development. The interactions revealed between EMP603 and PMH2-5140, ODB1-0814, ODB1-5061, and Zm-mCSF1 indicate a possible involvement of a dynamic ‘spliceosome-like’ complex in intron splicing, and may accelerate the elucidation of the intron splicing mechanism in plant mitochondria.
Using finite-state machines to automatically scan Ancient Greek hexameter
Authors: Schumann Anne-Kathrin , Beierle Christoph , Blößner Norbert 
Published: July 2021

Abstract
This article presents a fully automatic approach to the scansion of Ancient Greek hexameter verse. In particular, the article describes an algorithm that uses deterministic finite-state automata and local linguistic rules to implement a targeted search for valid spondeus patterns and, in addition, a weighted finite-state transducer to correct and complete partial analyses and to reject invalid candidates. The article also details the results of an empirical evaluation of the annotation quality resulting from this approach on hand-annotated data. It is shown that a finite-state approach provides quick and linguistically sound analyses of hexameter verses as well as an efficient formalization of linguistic knowledge. The project code is available online.1
New psychoactive substances, safety and mental health in prison officers
Authors: Kinman G , Clements A J 
Published: July 2021

Abstract

Background
The use of new psychoactive substances (NPS) in UK prisons is believed to have increased substantially. As well as posing a significant threat to prisoners’ health, NPS use can trigger violent, unpredictable and aggressive behaviour. Dealing with the direct and indirect effects of NPS therefore has the potential to compromise the physical and psychological safety of prison staff.

Aims
This study investigates prison officers’ perceptions of NPS use in their workplace and their risk of exposure. Relationships between NPS exposure, the workplace safety climate and mental health were also examined.

Methods
We assessed prison officers’ perceptions of the prevalence of NPS use among prisoners in their workplace, their personal exposure and the safety climate in their institution through an online survey. The General Health Questionnaire-12 measured mental health. Descriptive statistics were used to assess officers’ perceptions of NPS use in their workplace and their personal exposure and correlations examined relationships between variables.

Results
The sample comprised 1956 prison officers (86% male). Most respondents (85%) highlighted NPS as a serious cause for concern in their institution. Two-thirds (66%) reported being personally exposed to NPS at least sometimes, with 22% being exposed once a day or more. Significant relationships were found between officers’ perceived NPS exposure, assessments of safety climate and self-reported mental health.

Conclusions
Our findings highlight the need for urgent action to reduce the use of NPS among prisoners. This is likely to improve the safety climate of UK prisons and the mental health of staff.
Pain Location Is Associated with Fracture Type in Acute Osteoporotic Thoracolumbar Vertebral Fracture: A Prospective Observational Study
Authors: Zhang Haiping , Yang Bo , Hao Dingjun , Wang Biao , He Baorong , Sun Honghui , Li Hui , Zhang Xuefang 
Published: July 2021

Abstract

Objective
This study investigated the relationship between pain location and fracture type in patients with acute osteoporotic vertebral fracture (OVF).

Design
A prospective observational study.

Subject
A total of 306 patients with acute OVF were included.

Methods
The site of pain of each patient was recorded, and the patients were divided into a group with pain at the fracture site (group 1) and a group with pain at a non-fracture site (group 2). Fractures were classified into four types: type I, upper endplate type; type II, central type; type III, lower endplate type; and type IV, burst type.

Results
There were 146 patients in group 1, of whom 20.55% (30/146) had type I fractures, 33.56% (49/146) had type II fractures, 15.75% (23/146) had type III fractures, and 30.14% (44/146) had type IV fractures. There were 227 patients in group 2, of whom 57.27% (130/227) had type I fractures, 5.29% (12/227) had type II fractures, 35.24% (80/227) had type III fractures, and 2.20% (5/227) had type IV fractures. There was a statistical difference in the fracture type distribution between the two groups (P &lt; 0.05). The visual analog scale score in group 1 was higher than that in group 2 at the initial diagnosis (P &lt; 0.05).

Conclusions
For patients with acute OVF, the site of pain is related to the type of fracture. The pain at the fracture site is more often observed in the central type and burst type of fractures, whereas pain at a non-fracture site is more often observed in the upper and lower endplate types of fractures. Additionally, when OVF is suspected, radiological assessment of the thoracic and lumbar spine is recommended to better detect fractures that could cause pain distal to the site of the fracture.
Association of snoring characteristics with predominant site of collapse of upper airway in obstructive sleep apnea patients
Authors: Sebastian Arun , Cistulli Peter A , Cohen Gary , de Chazal Philip 
Published: July 2021

Abstract

Study Objectives
Acoustic analysis of isolated events and snoring by previous researchers suggests a correlation between individual acoustic features and individual site of collapse events. In this study, we hypothesized that multiparameter evaluation of snore sounds during natural sleep would provide a robust prediction of the predominant site of airway collapse.

Methods
The audio signals of 58 obstructive sleep apnea patients were recorded simultaneously with full-night polysomnography. The site of collapse was determined by manual analysis of the shape of the airflow signal during hypopnea events and corresponding audio signal segments containing snore were manually extracted and processed. Machine learning algorithms were developed to automatically annotate the site of collapse of each hypopnea event into three classes (lateral wall, palate, and tongue base). The predominant site of collapse for a sleep period was determined from the individual hypopnea annotations and compared to the manually determined annotations. This was a retrospective study that used cross-validation to estimate performance.

Results
Cluster analysis showed that the data fit well in two clusters with a mean silhouette coefficient of 0.79 and an accuracy of 68% for classifying tongue/non-tongue collapse. A classification model using linear discriminants achieved an overall accuracy of 81% for discriminating tongue/non-tongue predominant site of collapse and accuracy of 64% for all site of collapse classes.

Conclusions
Our results reveal that the snore signal during hypopnea can provide information regarding the predominant site of collapse in the upper airway. Therefore, the audio signal recorded during sleep could potentially be used as a new tool in identifying the predominant site of collapse and consequently improving the treatment selection and outcome.
Selling the Ability to “Have It All”: How Direct Selling Organizations Exploit Intensive Mothering Ideologies
Authors: Rees Mallory E 
Published: July 2021

Abstract
Drawing on 27 interviews with consultants in the direct selling industry, this article argues that consultants’ motivations to do stigmatized work with low financial rewards are tied to cultural pressures to adhere to intensive mothering ideologies. Some direct selling organizations in the United States are changing from a home party model—selling products out of homes—to a social commerce model—selling and recruiting using social media. Using a gendered organizations approach, these organizations portray themselves as feminine organizations, celebrating caregiving and allowing consultants—predominantly women—to reconcile work-family tensions through flexible work. Yet, this business model incentivizes a small number of financially successful consultants to train a much larger group to perform costly emotional labor for low pay. Consultants use the guilt tied to intensive mothering ideologies as a motivational tool in which they portray the cultural benefits of being a “good mother”—always available to and cultivating her children—as outweighing the emotional cost of doing stigmatized work that strains personal relationships. Rather than financially or emotionally supporting women, these organizations exploit women’s investments in finding individualized solutions to work-family conflict and reaffirm racialized, classed, and sexualized ideologies.
First Report of Alternaria alternata and Fusarium spp. Causing Brown Apical Necrosis in Walnut Fruit in Southern Chile
Authors: Moya-Elizondo Ernesto A. , Lagos María José , San Martin Juan , Ruiz Braulio 
Published: July 2021

This is the first report of Alternaria alternata and Fusarium spp. causing brown apical necrosis (BAN) in walnut fruit in southern Chile. English walnut (Juglans regia L.) is the second most widely grown fruit in Chile. The bacterial pathogen Xanthomonas arboricola pv. juglandis affects walnut production in Chile and has been associated with apical necrosis symptom and premature fruit drop; this research focused on determining if fungal pathogens were associated with this damage. The presence of BAN in commercial walnut orchards in southern Chile reveals the need for improved phytosanitary programs to control this disease.
Reducing the sting
Authors: Boburka Samantha M. 
Published: July 2021

ABSTRACT
Hymenoptera species include stinging insects such as wasps, hornets, bees, and fire ants. Allergic reaction to the venom of these insects is a common presenting complaint for patients in primary care and emergency medicine during warmer months. Patients' clinical presentations may vary, and clinicians must identify the type of reaction to determine treatment and follow-up plans. Treatment of patients allergic to Hymenoptera venom should be individualized based on risk factors, reaction type, and associated comorbidities. This article reviews common features of clinical presentation, diagnosis, and the current mainstays in management of Hymenoptera venom allergy.
Early Opiate Analgesic Requirements Following Nonsurgically Managed Tibial Fractures in Children
Authors: Yap Rye Y. , Sultan Sanaah , Ahmad Husham , Marson Ben , Ikram Adeel , Ollivere Benjamin , Lawniczak Dominik 
Published: July 2021

Background:
Many children with tibial fractures are currently being managed as outpatients. It is unclear how much opiates should be prescribed to ensure adequate analgesia at home without overprescription. This study aimed to evaluate the risk factors for requiring opiates following admission for tibial fractures and to estimate opiate requirements for children being discharged directly from the emergency department (ED).

Methods:
All children aged 4 to 16 years admitted with closed tibial fractures being treated in a molded circumferential above-knee plaster cast between October 2015 and April 2020 were included. Case notes were reviewed to identify demographics, analgesic prescriptions, and complications. Risk factors were analyzed using logistic regression.

Results:
A total of 75 children were included, of which 64% were males. The mean age was 9.5 (SD 3.4) years. Opiates were required by 36 (48%) children in the first 24 hours following admission. The median number of opiate doses in the first 48 hours was 0 (range: 0 to 5), with 93% of children receiving ≤3 doses. The odds of requiring opiates in the first 24 hours were unchanged for age above 10 years [odds ratio (OR)=0.85, 95% confidence interval (CI): 0.33-2.23], male sex (OR=1.58, 95% CI: 0.59-4.19), high-energy injury (OR=1.65, 95% CI: 0.45-6.04), presence of a fibula fracture (OR=2.21, 95% CI: 0.72-6.76), or need for fracture reduction in the ED (OR=0.57, 95% CI: 0.20-1.65). No children developed compartment syndrome, and the mean length of stay was 1.4 (SD 1.2) days. No children were readmitted following discharge.

Conclusions:
We have found no cases of compartment syndrome or extensive requirement for opiates following closed tibial fractures treated in plaster cast. These children are candidates to be discharged directly from the ED. We have not identified any specific risk factors for the targeting of opiate analgesics. We recommend a guideline prescription of 6 doses of opiates for direct discharge from the ED to ensure adequate analgesia without overprescription.

Level of Evidence:
Level IV—case series.
Development of Tuberculosis Spine Instability Score (TSIS)
Authors: Ahuja Kaustubh , Kandwal Pankaj , Ifthekar Syed , Sudhakar Pudipetti Venkata , Nene Abhay , Basu Saumyajit , Shetty Ajoy Prasad , Acharya Shankar , Chhabra Harvinder Singh , Jayaswal Arvind 
Published: July 2021

Study Design.
An expert-panel consensus-based content validation and case-based clinical validation study.

Objective.
To develop a novel scoring system for diagnosing instability in tuberculosis (TB) spine using an expert-panel consensus followed by clinical validation for validating the content.

Summary of Background Data.
Currently, diagnosis of instability is primarily experience-based which may lead to considerable variability and misdiagnosis in the hands of a relatively in-experienced spine surgeon. Considering the potential complications this entity entails, a universally accepted scoring criteria is very important for accurate and uniform diagnosis of instability in TB spine.

Methods.
The development of TB spine instability score (TSIS) followed a two-step process, one designing the instrument and the other obtaining judgemental evidence. For judgemental evidence a panel of experts was appointed to make appropriate modifications and content validation for finalizing the scoring instrument. This score was applied on 30 patients of TB spine and receiver operating characteristic (ROC) curves were drawn for sensitivity and specificity analysis.

Results.
The comprehensive scoring criteria to diagnose instability in TB spine was approved after three rounds of expert panel discussions with an index of content validation more than 0.75 after final round of panel discussion. On case-based validation after plotting ROC curves, sensitivity and specificity for diagnosing stable and potentially unstable lesions at a cut-off score of 6 was 92.9% and 86.8% respectively whereas for diagnosing potentially unstable and unstable lesions at a cut-off score of 10 was 94.3% and 81.9%, respectively.

Conclusion.
TSIS is a comprehensive scoring system integrating demographic, anatomical, clinical, and radiological factors aimed at diagnosing instability in TB spine. The classification determines indications for surgical stabilization in patients with TB spine, with no or little neurological deficit.

Level of Evidence: 4
Monitoring Antihypertensive Medication Adherence by Liquid Chromatography–Tandem Mass Spectrometry: Method Establishment and Clinical Application
Authors: Wang Yue , Wang Joanne W. , Wang Yanbin , Yang Bing , Yinghua Du Alicia , Kong Ziqing , Chen Minglong , Wang Jie 
Published: July 2021

Abstract:
Proper medication compliance is critical for the integrity of clinical practice, directly related to the success of clinical trials to evaluate both pharmacological-based and device-based therapies. Here, we established a liquid chromatography–tandem mass spectrometry method to accurately detect 55 chemical entities in the human urine sample, which accounting for the most commonly used 172 antihypertensive drugs in China. The established method had good accuracy and intraday and interday precision for all analyses in both bench tests and validated in 21 hospitalized patients. We used this method to monitor and ensure drug compliance and exclude the inferring impacts of medication compliance as a key confounder for our pivotal trial of a catheter-based, renal mapping and selective renal denervation to treat hypertension. It is found that in the urine samples from 92 consecutive subjects, 85 subjects (92.4%) were consistent with their prescriptions after 28 days run-in periods, 90 (97.8%) and 85 (95.5%) patients completely complied with their medications during the 3-month and 6-month follow-up period, respectively. Thus, using the liquid chromatography–tandem mass spectrometry method with specificity, accuracy, and precision, we ensured drug compliance of patients, excluded the key confounder of drug interferences, and ensured the quality of our device-based clinical trial for treatment of hypertension.
Precut Cast: An Easier and Less Stressful Cast Removal Procedure for Pediatric Patients
Authors: Tamaki Megumi , Dogo Kyoko , Fukuba Michiko , Komuro Yuzo , Okochi Masayuki 
Published: July 2021

SUMMARY:
During hospitalization, pediatric patients or their parents may feel stressed. If patients need to stay in the hospital with a cast, they are prone to feeling more stressed. Fixation using a cast is an important clinical option, particularly in the case of skin grafts wherein fixation of the foot and ankle is essential to ensure the survival of the graft skin. However, the removal of the cast is also stressful for patients because it needs to be removed with a cast saw. To avoid further stress in pediatric patients, we cut the cast intraoperatively and then fixed the cast again using nylon cable ties. One week after surgery, we separated the patient’s cast. Instead of using a cast saw, we used only scissors or nippers. Our cast removal method was easy, safe, and less stressful.
Impact of Anaerobic Antibacterial Spectrum on Cystic Fibrosis Airway Microbiome Diversity and Pulmonary Function
Authors: Bozzella Michael J. , Chaney Hollis , Sami Iman , Koumbourlis Anastassios , Bost James E. , Zemanick Edith T. , Freishtat Robert J. , Crandall Keith A. , Hahn Andrea 
Published: July 2021

Background:
The role of anaerobic organisms in the cystic fibrosis (CF) lung microbiome is unclear. Our objectives were to investigate the effect of broad (BS) versus narrow (NS) spectrum antianaerobic antibiotic activity on lung microbiome diversity and pulmonary function, hypothesizing that BS antibiotics would cause greater change in microbiome diversity without a significant improvement in lung function.

Methods:
Pulmonary function tests and respiratory samples were collected prospectively in persons with CF before and after treatment for pulmonary exacerbations. Treatment antibiotics were classified as BS or NS. Gene sequencing data from 16S rRNA were used for diversity analysis and bacterial genera classification. We compared the effects of BS versus NS on diversity indices, lung function and anaerobic/aerobic ratios. Statistical significance was determined by multilevel mixed-effects generalized linear models and mixed-effects regression models.

Results:
Twenty patients, 6–20 years of age, experienced 30 exacerbations. BS therapy had a greater effect on beta diversity than NS therapy when comparing time points before antibiotics to after and at recovery. After antibiotics, the NS therapy group had a greater return toward baseline forced expiratory volume at 1 second and forced expiratory flow 25%–75% values than the BS group. The ratio of anaerobic/aerobic organisms showed a predominance of anaerobes in the NS group with aerobes dominating in the BS group.

Conclusions:
BS antianaerobic therapy had a greater and possibly longer lasting effect on the lung microbiome of persons with CF, without achieving the recovery of pulmonary function seen with the NS therapy. Specific antibiotic therapies may affect disease progression by changing the airway microbiome.