bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orally administered oxygen nanobubbles enhance tumor response to sonodynamic therapy
Authors: Owen Joshua , Logan Keiran , Nesbitt Heather , Able Sarah , Vasilyeva Alexandra , Bluemke Emma , Kersemans Veerle , Smart Sean , Vallis Katherine A. , McHale Anthony P. , Callan John F. , Stride Eleanor 
Published: June 2021

AbstractSuspensions of oxygen‐filled bubbles are under active investigation as potential means of relieving tissue hypoxia. Intravenous administration of large quantities of bubbles is, however, undesirable. Previous work by the authors has demonstrated that tumor oxygen levels can be increased following oral administration of phospholipid stabilized oxygen nanobubbles. The aim of this study was to determine whether this would enhance the efficacy of sonodynamic therapy (SDT), which is known to be inhibited in hypoxic tissue. Experiments were conducted in a murine model of pancreatic cancer. Animals were treated with SDT (intratumoural injection of 1 mM Rose Bengal followed by exposure to 1 MHz ultrasound, 0.1 kHz pulse repetition frequency, 30% duty cycle, 3.5 W cm−2 for 3.5 minutes) either with or without a prior gavage of oxygen bubbles. A statistically significant reduction in the rate of tumor growth was observed in the groups receiving oxygen nanobubbles either 5 or 20 minutes before SDT. Separate measurements of tumor oxygen using a fiber optic probe and expression of hypoxia inducible factor (HIF)1α following tumor excision, confirmed the change in tumor oxygen levels. These findings offer a potentially promising new approach to relieving tissue hypoxia in order to facilitate cancer therapy.
Intensive nutrition support may benefit patients with a rare mitochondrial disorder
Authors: Kasti Arezina , Nikolaki Maroulla , Pyrousis Ioannis , Synodinou Kalliopi , Oikonomopoulos Nikolaos , Triantafyllou Konstantinos 
Published: June 2021

AbstractMitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare, inherited, multisystemic autosomal recessive disorder caused by mutations in the nuclear TYMP gene. This syndrome is characterized by ptosis, external ophthalmoplegia, gastrointestinal dysmotility, cachexia, peripheral neuropathy, and leukoencephalopathy. Our case illustrates a patient diagnosed with MNGIE and cachexia who has benefited from the initiation and maintenance of parenteral nutrition. We highlight the benefits of receiving long‐term supplementary home parenteral nutrition under close monitoring for patients with this neurogastrointestinal disease in order to gain weight and maintain good health.
Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001–2014
Authors: Pocobelli Gaia , Dublin Sascha , Bobb Jennifer F. , Albertson‐Junkans Ladia , Andrade Susan , Cheetham T. Craig , Salgado Gladys , Griffin Marie R. , Raebel Marsha A. , Smith David , Li De‐Kun , Pawloski Pamala A. , Toh Sengwee , Taylor Lockwood , Hua Wei , Horn Pamela , Trinidad James P. , Boudreau Denise M. 
Published: June 2021

AbstractPurposeTo estimate prevalence of prescription opioid use during pregnancy in eight US health plans during 2001–2014.MethodsWe conducted a cohort study of singleton live birth deliveries. Maternal characteristics were ascertained from health plan and/or birth certificate data and opioids dispensed during pregnancy from health plan pharmacy records. Prevalence of prescription opioid use during pregnancy was calculated for any use, cumulative days of use, and number of dispensings.ResultsWe examined prevalence of prescription opioid use during pregnancy in each health plan. Tennessee Medicaid had appreciably greater prevalence of use compared to the seven other health plans. Thus, results for the two groups were reported separately. In the seven health plans (n = 587 093 deliveries), prevalence of use during pregnancy was relatively stable at 9%–11% throughout 2001–2014. In Tennessee Medicaid (n = 256 724 deliveries), prevalence increased from 29% in 2001 to a peak of 36%–37% in 2004–2010, and then declined to 28% in 2014. Use for ≥30 days during pregnancy was stable at 1% in the seven health plans and increased from 2% to 7% in Tennessee Medicaid during 2001–2014. Receipt of ≥5 opioid dispensings during pregnancy increased in the seven health plans (0.3%–0.6%) and Tennessee Medicaid (3%–5%) during 2001–2014.ConclusionDuring 2001–2014, prescription opioid use during pregnancy was more common in Tennessee Medicaid (peak prevalence in late 2000s) compared to the seven health plans (relatively stable prevalence). Although a small percentage of women had opioid use during pregnancy for ≥30 days or ≥ 5 dispensings, they represent thousands of women during 2001–2014.
A conditional female lethal system for genetic suppression of the global fruit crop pest Drosophila suzukii
Authors: Li Fang , Yamamoto Akihiko , Belikoff Esther J , Berger Amy , Griffith Emily H , Scott Maxwell J 
Published: June 2021

AbstractBACKGROUNDDrosophila suzukii (Matsumura, 1931, Diptera: Drosophilidae) is a global pest of soft‐skinned fruits such as blueberries, cherries and raspberries. Also known as spotted‐wing drosophila, D. suzukii is native to Asia but is now widely distributed in the Americas and Europe, and presents a serious challenge for growers. Genetic control strategies offer an environmentally friendly approach for the control of D. suzukii.RESULTSIn this study, we developed transgenic strains of D. suzukii that carry dominant conditional female lethal transgenes. When raised in the absence of tetracycline, female D. suzukii die. We show that repeated releases of an excess of transgenic males can suppress D. suzukii populations in laboratory cage trials.CONCLUSIONOur data suggest that the transgenic strain could provide an effective approach for control of this invasive pest of soft‐skinned fruits.
Aperiodic sampled‐data controller design for stochastic Markovian jump systems and its application
Authors: Yang Te , Wang Zhen , Huang Xia , Xia Jianwei , Chen Guoliang 
Published: June 2021

AbstractIn this paper, aperiodic sampled‐data controller design problem is solved for stochastic Markovian jump systems (SMJSs). By introducing mode‐dependent one‐sided loop‐based Lyapunov functional and mode‐dependent two‐sided loop‐based Lyapunov functional and using Itô formula, two different stochastic stability conditions for SMJSs under aperiodic sampled‐data control are presented, respectively. Based on these two stability conditions, corresponding mode‐dependent aperiodic sampled‐data controller is designed for SMJSs. Finally, practical aircraft model are applied to illustrate the effectiveness of the method. It is also shown that mode‐dependent two‐sided loop‐based Lyapunov functional can obtain a larger upper bound of the sampling interval than mode‐dependent one‐sided loop‐based Lyapunov functional.
Biodegradable Polyurethane Solid‐Solid Phase Change Materials
Authors: Oktay Burcu , Kayaman‐Apohan Nilhan 
Published: June 2021

AbstractPolyurethane based phase change material (PCM) was prepared using polyethylene glycol (PEG), isophoronediisocyanate and octadecanol via a two‐step process. PEG and octadecanol served as phase change components. The structural characterization of PCM was performed by ATR‐FTIR and 1H‐NMR spectroscopies. The latent heat, phase change temperature and thermal stability of PCM were characterized by differential scanning calorimetry and thermogravimetric analysis. The results show that PCM has an excellent energy storage capacity, suitable phase transition temperatures and great thermal stability at 100 °C without leakage. PEG/octadecanol polyurethane PCM reached 126 and 95 J/g enthalpy values. To investigate the efficiency of the PCM in a biodegradable polymeric support, blend films were prepared by mixing PEG/octadecanol polyurethane with the PLA. Films exhibited high light transmission. Elongation at break increased compared with pure PLA from 6 % to 87 %. In addition, tensile strength and modules of PLA/PEG‐octadecanol PCM decreased. Water contact angle values of the films increased to 66 and 70° with adding polyurethane PCM. In conclusion, PLA/PCMs exhibited high thermal energy storage property and suitable phase change temperature as good as the PEG/octadecanol polyurethane PCM. Therefore, PLA/PCMs can be used in ranges between 10 and 55° C.
“Turn‐on” Fluorescence Chemosensor Based Probing of Cu2+ with Excellent Sensitivity: Experimental Study, DFT Calculations and Application in Living Cells and Natural Waters
Authors: Savran Tahir , Nihan Karuk Elmas Sukriye , Akin Geyik Gonul , Bostanci Aykut , Aydin Duygu , Nur Arslan Fatma , Sadi Gökhan , Yilmaz Ibrahim 
Published: June 2021

AbstractDeveloping selective, precise, and rapid determination methods for Cu2+ sensing is of great significance for biological systems, public health, and environmental protection. Hence, a new coumarin‐based fluorescent chemosensor 3‐((E)‐(((E)‐3,5‐di‐tert‐butyl‐2‐hydroxybenzylidene)hydrazono) methyl)‐7‐(diethylamino)‐2H‐chromen‐2‐one (HBAC) for Cu2+ sensing in MeOH:H2O (80 : 20, v:v, pH=7 PBS buffer) media has been constructed. HBAC responded to Cu2+ with high selectivity and exhibited a relatively low LOD of 7.0 nM and ∼22‐fold fluorescent enhancement at 461 nm with the addition of Cu2+ (0.0‐5.0 μM). The reaction mechanism of the HBAC‐Cu2+ system has been fully examined by MALDI‐TOF‐MS, FT‐IR, and time dependent‐density functional theory (TD‐DFT) calculations. The sensing mechanism was occurred due to the chelation enhanced fluorescence (CHEF) and inhibition of PET phenomena. Furthermore, the chemosensor HBAC for Cu2+ sensing in living systems and natural spring water samples has been successfully utilized, suggesting that the prepared HBAC is an appropriate chemosensor for examining Cu2+ in biological and environmental systems.
In Situ Construction of Porous g‐C3N4 Isotype Heterojunction/BiOBr Nanosheets Ternary Composite Catalyst for Highly Efficient Visible‐Light Photocatalytic Activity
Authors: Jiang Tingshun , Han Hui , Dong Mingfeng , Zhao Qian 
Published: June 2021

AbstractIn this study, the composite catalysts with the heterojunction between DUPG and BiOBr were used to degrade methyl orange (MO), and a g‐C3N4‐based ternary composite catalyst was developed. In our previous work, we prepared a D‐C3N4/U‐C3N4 isotype heterojunction with ordered mesoporous (DUPG) by co‐mixed calcination and hard template method. On this basis, we prepared DUPG/BiOBr nanoparticle uniformly distributed on DUPG nanosheets by coprecipitation self‐assembly method. The hybrids form a tightly coupled heterojunction that enhances the photoactivity and photostability of the DUPG/BiOBr composites. The results show that this tight coupling is beneficial, which facilitates the charge transfer between DUPG and BiOBr, thus promoting the effective separation of photogenerated electron hole pairs. Under visible light irradiation, the methyl orange conversion of the sample has higher photocatalytic reduction activity than BiOBr and DUPG, and its excellent photocatalytic activity is improved by light‐harvesting ability, increased specific surface area, active species and target pollution.
Ambipolar Field‐Effect Transistor Based on CH3NH3PbI3 Microwires
Authors: Gao Jinghan , Lv Qianrui 
Published: June 2021

AbstractOrganic‐inorganic hybrid perovskites are promising semiconductors for high‐performance field‐effect transistors because of their excellent charge carrier transport, but hybrid perovskites used in field‐effect transistors are not diverse enough and the field‐effect performances are always not satisfactory at room temperature and in the dark and air. Herein, we prepared CH3NH3PbI3 microwires through a transformation from CH3NH3PbI3 bulk single crystals and fabricated ambipolar field‐effect transistors based on them. At room temperature and in the dark and air, the field‐effect mobility can reach to 1.8×10−3 cm2V−1 s−1, which is two orders of magnitude higher than that of CH3NH3PbI3 polycrystalline film based field‐effect transistors under the same condition, indicating that CH3NH3PbI3 microwires have potential for use in ambipolar transistors.
On Thiol‐Ene Radical Coupling Reaction when Synthesis of ABCL2Type Heteroarm Star Copolymer Containing PDPA Arm
Authors: Wang Xin , Liu Yuyang , Yan Lei 
Published: June 2021

AbstractIn this paper, we designed novel ABCL2‐type heteroarm star copolymers, where A, B and C are poly(ϵ‐caprolactone) (PCL), poly(2‐(diisopropylamino) ethyl methacrylate) (PDPA) and poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC) arms, respectively, and L is 4‐([2,2′:6′,2′′‐terpyridine]‐4′‐yl) phenyl (Tpyp) ligand group. In the final synthesis step, thiol‐ene radical coupling was used to link PMPC chain onto PCL/PDPA copolymer to form a heteroarm star copolymer. However, it was found that the presence of the PDPA block with tertiary amine moieties led the thiol‐ene radical coupling not to be achieved easily in common conditions. Herein we focus on investigating the photoinitiated thiol‐ene coupling reaction. Finally, we achieve the reaction via selecting appropriate solvent. It is expected that the exploration can broaden application of thiol‐ene radical reaction in synthesis of polymer architectures.
Reversible Photoswitchable Inhibitors Enable Wavelength‐Selective Regulation of Out‐of‐Equilibrium Bi‐enzymatic Systems
Authors: Teders Michael , Murray Nicholas R. , Huck Wilhelm T. S. 
Published: June 2021

AbstractThe construction of synthetic enzymatic reaction networks can provide new insights into the design principles of living systems. However, the programmable connection of enzymes into a wide range of network topologies has been challenging due to the lack of a general strategy enabling a reversible activity regulation of individual network enzymes. Here, we exploit a general and modular strategy based on the external regulation of enzymes using light and photoswitchable inhibitors (PIs) that enables the bottom‐up construction and control of enzymatic systems studied under out‐of‐equilibrium conditions. Upon synthesis and incorporation of potent photoswitchable trypsin inhibitors (Tr‐PIs), the output of several functional enzymatic systems could be photoregulated using 390/460 nm light as a trigger signal. In addition, the wavelength‐selective control over the activity of two enzymes within a functional bi‐enzymatic system was achieved using a suitable combination of two PIs.
Synthesis of Thiodisaccharides Bearing N‐Acetylhexosamine Residues: Challenges, Achievements and Perspectives
Authors: Cristófalo Alejandro E. , Cano María Emilia , Uhrig María Laura 
Published: June 2021

AbstractCarbohydrate‐protein interactions are involved in a myriad of biological processes. Thus, glycomimetics have arisen as one of the most promising synthetic targets to that end. Within the broad variety of glycomimetics, thiodisaccharides have proven to be excellent tools to study these processes, and even more, some of them unveiled interesting biological activities. This review brings together research made on the introduction of N‐acetylhexosamine residues into thiodisaccharides to date, passing through classic substitution (as SN2, thioglycosylation and ring‐opening reactions) and addition (as thiol‐ene coupling and Michael‐type additions) reactions. Recent and interesting developments regarding addition reactions to vinyl azides, cross‐coupling reactions and novel chemoenzymatic methods are also discussed.
A thermoelastic micro‐elongated layer under the effect of gravity in the context of the dual‐phase lag model
Authors: Othman Mohamed I. A. , Atwa Sarhan Y. , Eraki Ebtesam E. M. , Ismail Mohamed F. 
Published: June 2021

AbstractThis paper aims to present a Lord‐Shulman theory of one relaxation time and the dual‐phase‐lag model of two‐relaxation times to study the effect of gravity on both the micro‐elongated thermoelasticity layer and the elastic layer in the above. The normal mode analysis was used to obtain the expressions of the displacement components, the micro‐elongational scalar, and the stress components. Comparisons between the physical quantities were getting numerically and epitomized graphically. The results depict the effect of the presence and absence of gravity and the relaxation times on all the physical quantities.
Breeding history and husbandry of the Superb Bird‐of‐paradise (Lophorina superba)
Authors: Rimlinger David , Theule Jessica , Bass Kelly 
Published: June 2021

AbstractThe Superb Bird‐of‐paradise (Lophorina superba) has been bred in captivity for more than 50 years but has not been well documented. San Diego Zoo began efforts to breed the Superb Bird‐of‐paradise in the late 1960s. Through the years, behavioral observations by animal staff have led to improvements in husbandry techniques which have led to increased reproductive success. Enclosure setup and pair management are particularly important. The ability to maintain breeding pairs in adjacent enclosures, in which the male can maintain visual contact with the female, establish a territory, be given access to a female for copulation and then be separated again has proven paramount for nesting success. Additionally, diet and planned timing of introduction have played a beneficial role for successful breeding year after year.
Matching in $$ pp\to t\overline{t}W/Z/h+ $$ jet SMEFT studies
Authors: Goldouzian Reza , Kim Jeong Han , Lannon Kevin , Martin Adam , Mohrman Kelci , Wightman Andrew 
Published: June 2021

Abstract
In this paper, we explore the impact of extra radiation on predictions of $$ pp\to \mathrm{t}\overline{\mathrm{t}}\mathrm{X},\mathrm{X}=\mathrm{h}/{\mathrm{W}}^{\pm }/\mathrm{Z} $$
pp
→
t

t
¯

X
,
X
=
h
/

W
±

/
Z
processes within the dimension-6 SMEFT framework. While full next-to-leading order calculations are of course preferred, they are not always practical, and so it is useful to be able to capture the impacts of extra radiation using leading-order matrix elements matched to the parton shower and merged. While a matched/merged leading-order calculation for $$ \mathrm{t}\overline{\mathrm{t}}\mathrm{X} $$
t

t
¯

X
is not expected to reproduce the next-to-leading order inclusive cross section precisely, we show that it does capture the relative impact of the EFT effects by considering the ratio of matched SMEFT inclusive cross sections to Standard Model values, $$ {\sigma}_{\mathrm{SM}\mathrm{EFT}}\left(\mathrm{t}\overline{\mathrm{t}}\mathrm{X}+\mathrm{j}\right)/{\sigma}_{\mathrm{SM}}\left(\mathrm{t}\overline{\mathrm{t}}\mathrm{X}+\mathrm{j}\right)\equiv \mu $$

σ
SMEFT

t

t
¯

X
+
j

/

σ
SM

t

t
¯

X
+
j

≡
μ
. Furthermore, we compare leading order calculations with and without extra radiation and find several cases, such as the effect of the operator $$ \left({\varphi}^{\dagger }i{\overleftrightarrow{D}}_{\mu}\varphi \right)\left(\overline{t}{\gamma}^{\mu }t\right) $$

φ
†

i

D
↔

μ

φ

t
¯

γ
μ

t

on $$ \mathrm{t}\overline{\mathrm{t}}\mathrm{h} $$
t

t
¯

h
and $$ \mathrm{t}\overline{\mathrm{t}}\mathrm{W} $$
t

t
¯

W
, for which the relative cross section prediction increases by more than 10% — significantly larger than the uncertainty derived by varying the input scales in the calculation, including the additional scales required for matching and merging. Being leading order at heart, matching and merging can be applied to all operators and processes relevant to $$ pp\to \mathrm{t}\overline{\mathrm{t}}\mathrm{X},\mathrm{X}=\mathrm{h}/{\mathrm{W}}^{\pm }/\mathrm{Z}+\mathrm{jet} $$
pp
→
t

t
¯

X
,
X
=
h
/

W
±

/
Z
+
jet
, is computationally fast and not susceptible to negative weights. Therefore, it is a useful approach in $$ \mathrm{t}\overline{\mathrm{t}}\mathrm{X} $$
t

t
¯

X
+ jet studies where complete next-to-leading order results are currently unavailable or unwieldy.
Page curve from non-Markovianity
Authors: Su Kaixiang , Zhang Pengfei , Zhai Hui 
Published: June 2021

AbstractIn this paper, we use the exactly solvable Sachdev-Ye-Kitaev model to address the issue of entropy dynamics when an interacting quantum system is coupled to a non-Markovian environment. We find that at the initial stage, the entropy always increases linearly matching the Markovian result. When the system thermalizes with the environment at a sufficiently long time, if the environment temperature is low and the coupling between system and environment is weak, then the total thermal entropy is low and the entanglement between system and environment is also weak, which yields a small system entropy in the long-time steady state. This manifestation of non-Markovian effects of the environment forces the entropy to decrease in the later stage, which yields the Page curve for the entropy dynamics. We argue that this physical scenario revealed by the exact solution of the Sachdev-Ye-Kitaev model is universally applicable for general chaotic quantum many-body systems and can be verified experimentally in near future.
Constructing illoyal algebra-valued models of set theory
Authors: Löwe Benedikt , Paßmann Robert , Tarafder Sourav 
Published: June 2021

AbstractAn algebra-valued model of set theory is calledloyal to its algebraif the model and its algebra have the same propositional logic; it is calledfaithfulif all elements of the algebra are truth values of a sentence of the language of set theory in the model. We observe that non-trivial automorphisms of the algebra result in models that are not faithful and apply this to construct three classes of illoyal models: tail stretches, transposition twists, and maximal twists.
Equivalence à la Mundici for commutative lattice-ordered monoids
Authors: Abbadini Marco 
Published: June 2021

AbstractWe provide a generalization of Mundici’s equivalence between unital Abelian lattice-ordered groups and MV-algebras: the category ofunital commutative lattice-ordered monoidsis equivalent to the category ofMV-monoidal algebras. Roughly speaking, unital commutative lattice-ordered monoids are unital Abelian lattice-ordered groups without the unary operation$$x \mapsto -x$$x↦-x. The primitive operations are$$+$$+,$$\vee $$∨,$$\wedge $$∧, 0, 1,$$-1$$-1. A prime example of these structures is$$\mathbb {R}$$R, with the obvious interpretation of the operations. Analogously, MV-monoidal algebras are MV-algebras without the negation$$x \mapsto \lnot x$$x↦¬x. The primitive operations are$$\oplus $$⊕,$$\odot $$⊙,$$\vee $$∨,$$\wedge $$∧, 0, 1. A motivating example of MV-monoidal algebra is the negation-free reduct of the standard MV-algebra$$[0, 1]\subseteq \mathbb {R}$$[0,1]⊆R. We obtain the original Mundici’s equivalence as a corollary of our main result.