bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmented und Virtual Reality in der Chirurgie: Einsatzgebiete und explorative Studien am Beispiel von VIVATOP
Authors: Weyhe Dirk , Hartmann Verena , Uslar Verena , Tabriz Navid 
Published: January 2025

Zusammenfassung
Digitale Technologien wie Virtual und Augmented Reality (VR/AR) werden in der präklinischen und klinischen Phase vor allem in der Neurochirurgie sowie in der Orthopädie angewendet. Dagegen ist in der Viszeralchirurgie die Anwendung seltener, da die intraoperativen Deformationen herausfordernd für den klinischen Einsatz sind. Vor allem in der Aus- und Weiterbildung werden VR-Anwendungen erfolgreich eingesetzt. Neben aktuellen Anwendungsgebieten beleuchtet dieser Beitrag Ergebnisse des Projekts VIVATOP (Vielseitiger Immersiver Virtueller und Augmentierter Tangible OP) des Bundesministeriums für Bildung und Forschung (BMBF). Hier wurden AR- und VR-Technologien in Kombination mit 3‑D-Druck als Demonstratoren neu- bzw. weiterentwickelt. Es erfolgte die Entwicklung eines VR-Planungswerkzeugs zur Leberteilresektion, die Entwicklung von 3‑D-Hologrammen zur intraoperativen AR-Unterstützung und eine Avatartelemedizinfunktion sowie ein 3‑D-Druck-Trainingsmodell. Die klinischen Ergebnisse der intraoperativen AR-Unterstützung mit dem primären Endpunkt Operationsdauer und den sekundären Endpunkten Krankenhaus- und Intensivaufenthalt sowie Komplikationsraten werden mit einer historischen Kohorte verglichen und die Ergebnisse kontextualisiert.
An extra pair of eyes: adopting innovative approaches to detect integrity issues in Naunyn–Schmiedeberg’s Archives of Pharmacology
Authors: van Diest Ruben A. , Seifert Roland , van der Heyden Marcel A. G. 
Published: January 2025

Abstract
Scientific integrity has been increasingly challenged by scientific misconduct and paper mills, resulting in an increase in retractions. Naunyn–Schmiedeberg’s Archives of Pharmacology has been significantly impacted by fraudulent submissions, resulting in numerous retractions. By analyzing retraction notes and utilizing a post-publication surveillance strategy, this editorial discusses how this journal continues to deal with problematic publications, uncovers image- and physiological-related integrity issues, and responds to fraudulent activity. By adopting innovative methods to detect integrity issues and transparently communicating our concerns, we aim to increase awareness among scientists and scientific journals.
The correlation between LAG-3 expression and the efficacy of chemoimmunotherapy in advanced biliary tract cancer
Authors: Tang Cheng-Yu , Lin Yi-Ting , Yeh Yi-Chen , Chung Shin-Yi , Chang Yu-Chan , Hung Yi-Ping , Chen San-Chi , Chen Ming-Huang , Chiang Nai-Jung 
Published: January 2025

Abstract
In our previous phase II T1219 trial for advanced biliary tract cancer (ABTC), the combination of nivolumab with modified gemcitabine and S-1 exhibited promising efficacy, while the programmed-death-ligand-1 (PD-L1) expression did not predict chemoimmunotherapy efficacy. Lymphocyte-activation-gene-3 (LAG-3), a negative immune checkpoint, is frequently co-expressed with PD-L1. This study assessed the predictive value of LAG-3 expression in ABTC patients who received chemoimmunotherapy. We analyzed 44 formalin-fixed ABTC samples using immunohistochemical staining for PD-L1 and LAG-3 and correlated them with the clinical efficacy of chemoimmunotherapy. Digital spatial profiling was conducted in selected regions of interest to examine immune cell infiltration and checkpoint expression in six cases. Three public BTC datasets were used for analysis: TCGA-CHOL, GSE32225, and GSE132305. LAG-3 positivity was observed in 38.6% of the ABTC samples and was significantly correlated with PD-L1 positivity (P < 0.001). The objective response rate (ORR) was significantly higher in LAG-3-positive tumors than in LAG-3-negative tumors (70.6% vs. 33.3%, P = 0.029). The LAG-3 expression level was associated with an increased ORR (33%, 58%, and 100% for LAG-3 < 1%, 1–9%, and ≥ 10%, respectively; P = 0.018) and a deeper therapeutic response (20.1%, 38.6%, and 57.6% for the same respective groups; P = 0.04). LAG-3 expression is positively correlated with the expression of numerous immune checkpoints. Enrichment of CD8+ T cells was observed in LAG-3-positive BTC, indicating that LAG-3 expression may serve as a biomarker for identifying immune-inflamed tumors and predicting the therapeutic response to chemoimmunotherapy in ABTC.
Anti-PD1-/PDL1-induced chronic intestinal pseudo-obstruction: three cases treated with vedolizumab after corticosteroid failure with mixed results
Authors: Zenatri Morgan , Collins Michael , Alberto Tifanie , Farina Antonio , Collardeau-Frachon Sophie , Saint-Jean Mélanie , Bocquet François , Dumont Frederic , Honnorat Jérôme , Joubert Bastien , Raimbourg Judith 
Published: January 2025

Abstract
Immune checkpoint inhibitors (ICI), i.e., anti-PD1/PDL1 and anti-CTLA-4, have reshaped the prognosis of many cancers. Increased use of ICI has led to the onset of new adverse events. Neurological immune-related adverse events are rare, heterogenous, and potentially life-threatening. Chronic intestinal pseudo-obstruction (CIPO) is an immune-related autonomic plexus neuropathy that may be caused by infiltration of the myenteric plexus by CD8 + T cells. It is a rare and potentially fatal side effect that can be difficult to diagnose early because of initial nonspecific clinical presentation including vomiting, nausea, diarrhea, and constipation. Some rare cases have been described in the literature reporting a frequent resistance to corticosteroids making it necessary to use other immunosuppressive therapy. Vedolizumab is an antibody (Ab) blocking integrin α4-β7 used to treat inflammatory bowel disease. We report the first three cases of ICI-induced CIPO-treated with vedolizumab after corticosteroid failure, with very limited benefits (only one patient with transitory improvement). Based on our results in three cases, vedolizumab does not currently appear to be a therapeutic option. Earlier administration with a standardized dose and frequency schedule may provide better outcomes.
Unsupervised clustering reveals noncanonical myeloid cell subsets in the brain tumor microenvironment
Authors: Hermelo Ismaïl , Virtanen Tuomo , Salonen Iida , Nätkin Reetta , Keitaanniemi Sofia , Tiihonen Aliisa M. , Lehtipuro Suvi , Kummola Laura , Raulamo Ella , Nordfors Kristiina , Haapasalo Hannu , Rauhala Minna , Kesseli Juha , Nykter Matti , Haapasalo Joonas , Rautajoki Kirsi 
Published: January 2025

Abstract
The tumor immune microenvironment (TiME) of human central nervous system (CNS) tumors remains to be comprehensively deciphered. Here, we employed flow cytometry and RNA sequencing analysis for a deep data-driven dissection of a diverse TiME and to uncover noncanonical immune cell types in human CNS tumors by using seven tumors from five patients. Myeloid subsets comprised classical microglia, monocyte-derived macrophages, neutrophils, and two noncanonical myeloid subsets: CD3+ myeloids and CD19+ myeloids. T lymphocyte subsets included double-negative (CD4− CD8−) T cells (DNTs). Noncanonical myeloids and DNTs were explored on independent datasets, suggesting that our DNT phenotype represents γδ T cells. Noncanonical myeloids were validated using orthogonal methods across 73 patients from three independent datasets. While the proportions of classical myeloids agreed with reported malignancy type-associated TiMEs, unexpectedly high lymphocyte frequencies were detected in gliosarcoma, which also showed a unique expression pattern of immune-related genes. Our findings highlight the potential of data-driven approaches in resolving CNS TiME to reveal the mosaic of immune cell types constituting TiME, warranting the need for future studies on the nonclassical immune cell subsets.
A morphometric study of posterior tibial slope differences by sex and ethnicity in a South African population
Authors: Hohmann Erik , Nel Adri , Zyl Reinette van , Natalie Natalie , Mogale Nkhensani 
Published: January 2025

Abstract
Purpose
Posterior tibial slope (PTS) influences knee kinetics and kinematics. The purpose of this study was to investigate morphology and variation within a sample of the black and white male and female population.

Method
480 randomly selected lateral knee radiographs were included. The anterior tibial cortex angle (ATC), proximal anatomical tibial axis angle (PTAA) and the posterior tibial cortex angle (PTC) were measured using ImageJ 1.53e software. Between group differences (black male and females, white males and females) were analysed using one-way ANOVA.

Results
Significant differences between the three different angles (p = 0.0001, F = 50.68) but no between group differences for the individual angle measurements (ATC, PTAA, PTC) between ethnicity and sex. For ATC, the angles between groups ranged from 14.20 + 2.81 degrees (Females Black), 14.62 + 3.6 degrees (Male Black), 15.18 + 3.68 degrees (Male White) to 15.54 + 3.21 degrees (Females White). For PTAA, the angles between groups ranged from 10.37 + 2.59 degrees (Females Black), 10.61 + 3.27 degrees (Male Black), 10.68 + 3.27 degrees (Male White) to 10.83 + 3.27 degrees (Females White). For PTC, the angles between groups ranged from 6.07 + 3.13 degrees (Females White), 6.13 + 3.7 degrees (Male White), 6.35 + 2.67 degrees (Females Black) to 6.62 + 3.16 degrees (Male Black).

Conclusion
This study could not establish differences in posterior tibial slope angles between males and females and ethnicity. Significant differences between ATC, PTAA and PTC angles were observed and PTC angles were smaller when compared to PTAA and ATC angles. The ATC angles ranged between 13.18 and 16.57 degrees, the PTAA angles ranged 9.38–11.87 degrees and the PTC angles ranged between 5.03 and 7.62 degrees for all groups.
PD-L1 expression in high-risk non-muscle invasive bladder cancer is not a biomarker of response to BCG
Authors: de Jong Florus C. , Kvikstad Vebjørn , Hoedemaeker Robert F. , van der Made Angelique C. J. , van der Bosch Thierry P. , van Casteren Niels J. , van Kessel Kim E. M. , Zwarthoff Ellen C. , Boormans Joost L. , Zuiverloon Tahlita C. M. 
Published: January 2025

Abstract
Purpose
Up to 50% of high-risk non-muscle invasive bladder cancer (HR-NMIBC) patients fail Bacillus Calmette-Guérin (BCG) treatment, resulting in a high risk of progression and poor clinical outcomes. Biomarkers that predict outcomes after BCG are lacking. The antitumor effects of BCG are driven by a cytotoxic T cell response, which may be controlled by immune checkpoint proteins like Programmed Death Ligand 1 (PD-L1). Here, we hypothesized that PD-L1 protein expression could serve as a biomarker for BCG-failure.

Methods
HR-NMIBC patients who received ≥ 5 BCG instillations were included. Tissue microarrays were constructed from BCG-naïve tumors and recurrences and stained with the PD-L1 (SP142) antibody. PD-L1 status was defined as ≥ 5% tumor-infiltrating immune cells with membrane staining in the tumor area. Clinicopathological associations with PD-L1 positive tumors were investigated, and time-to-event analyses were performed comparing PD-L1 positive vs. negative tumors.

Results
432 BCG-naïve tumors and 160 recurrences were included, and 91% of patients received adequate BCG. In BCG-naïve tumors, PD-L1 was expressed in 7% of patients and PD-L1 expression was associated with stage T1 versus Ta disease (p = 0.015). PD-L1 expression was not associated with treatment failure after adequate BCG (p = 0.782) nor with progression-free survival (p = 0.732). Testing cut-offs of ≥ 1% and ≥ 10% PD-L1 positivity did not alter results. High PD-L1 expression was more frequent in tumor recurrences (14%) as compared to BCG-naïve tumors (p = 0.012).

Conclusion
PD-L1 expression in HR-NMIBC is not a biomarker of response to BCG. However, PD-L1 is higher in a subset of tumors that failed BCG treatment. More research is needed to determine the role of PD-L1 in tumors where BCG treatment failed.
Kirners deformity – a systematic review and surgery recommendations
Authors: Fülling Tim , Baade Carsten , Dragu Adrian , Nicklas Antek 
Published: January 2025

Abstract
Background
Kirner deformity is a rare anomaly of the little finger in adolescents, characterized by a deformity of the distal phalanx and a radiologically L-shaped epiphysis, along with palmar and radial angulation of the distal phalanx. Due to the rarity of these pathological findings, there are no systematic literature reviews available. This work serves as an overview of the clinical presentation, frequency and age distributions, as well as possible conservative and surgical treatment options.

Methods
We present five cases of patients with Kirner’s deformity of the little finger who underwent surgical treatment. A partial tenotomy of the flexor digitorum profundus tendon from the metaphyseal/diaphyseal distal phalanx was performed. In one case, a dorsal epiphysiodesis was also carried out. Additionally, a systematic review of the literature on Kirner’s deformity was conducted, summarizing the prevalence, previously used surgical treatment options, and epidemiological data.

Results
In the presented cases, the detachment of the FDP tendon and dorsal epiphysiodesis resulted in a good functional and aesthetic outcome. Regarding the epidemiological distribution of Kirner deformity, it is noted that significantly more females are affected than males (63% vs. 36%). The average age at presentation in the respective clinic was 9.36 years (± 2.5). In more than half of all reported cases, the deformity was bilateral. Surgical intervention was performed in only 7.4% of cases, which included FDP detachment or corrective osteotomies. More than 90% of patients were treated conservatively.

Conclusion
Kirner’s deformity is a rare condition affecting adolescents. In cases where functional limitations or pain symptoms are present, we recommend surgical intervention via detachment of the FDP tendon. If the deformity is an incidental finding without functional or aesthetic limitations, conservative therapy with a corrective splint can be initiated. From our perspective, early surgical treatment before the age of 12 improves both the long-term functional and aesthetic outcomes.
Intravenous thrombolysis in patients with acute dizziness or imbalance and suspected ischemic stroke-systematic review
Authors: Edlow Jonathan A. , Tarnutzer Alexander A. 
Published: January 2025

Abstract

Background
Correct identification of those patients presenting with an acute vestibular syndrome (AVS) or an acute imbalance syndrome (AIS) that have underlying posterior-circulation stroke (PCS) and thus may benefit from revascularization (intravenous thrombolysis (IVT), endovascular therapy (EVT)) is important. Treatment guidelines for AVS/AIS patients are lacking. We reviewed the evidence on acute treatment strategies in AVS/AIS focusing on predictors for IVT/EVT and outcome.

Methods
We performed a systematic search (MEDLINE, Embase) to identify studies reporting on acute treatment in PCS presenting as AVS/AIS (PROSPERO-registration = CRD42024537272). Key parameters were extracted. Risk of bias was assessed (Downs-and-Black quality assessment checklist).

Results
We identified 3883 citations and included seven study cohorts (n = 1000 patients including 950 ischemic strokes). Overall, 251/1000 patients (25.1%) received IVT; EVT was performed in 46/368 (12.5%). Acute vertigo/dizziness was reported in 295/1000 (29.5%) patients. AVS criteria were met in 186/407 (45.7%) patients evaluated, and AIS criteria in 82/346 (23.7%). IVT was reported in 71/195 (36.4%) AVS/AIS patients and EVT in 13/77 (16.9%) cases, whereas the door-to-needle time (DNT) was significantly longer for PCS compared to anterior-circulation stroke (90 ± 29min vs. 74 ± 30min, p = 0.003) in one study. DNT was similar in those patients presenting with AVS/AIS compared to all PCS presentations in another study (70 ± 39min (AVS/AIS) vs. 63 ± 35min (all)). An mRS

$$\le$$

≤

2 after 90 days was noted in 68.4–69.6% of PCS. No outcome data were identified for AVS/AIS patients.

Conclusions
Insufficient data exist to drive any firm recommendation about treating otherwise eligible patients with AVS/AIS with IVT/EVT and judgments must be made on a case-by-case basis. Further research on this specific patient group is needed.
FREIGHT: Fast Streaming Hypergraph Partitioning
Authors: Eyubov Kamal , Fonseca Faraj Marcelo , Schulz Christian 
Published: January 2025

Abstract
Partitioning the vertices of a (hyper)graph into k roughly balanced blocks such that few (hyper)edges run between blocks is a key problem for large-scale distributed processing. A current trend for partitioning huge (hyper)graphs using low computational resources are streaming algorithms. In this work, we propose FREIGHT: a Fast stREamInG Hypergraph parTitioning algorithm which is an adaptation of the widely-known graph-based algorithm Fennel. By using an efficient data structure, we make the overall running of FREIGHT linearly dependent on the pin-count of the hypergraph and the memory consumption linearly dependent on the numbers of nets and blocks. The results of our extensive experimentation showcase the promising performance of FREIGHT as a highly efficient and effective solution for streaming hypergraph partitioning. Our algorithm demonstrates competitive running time with the Hashing algorithm, with a geometric mean runtime within a factor of four compared to the Hashing algorithm. Significantly, our findings highlight the superiority of FREIGHT over all existing (buffered) streaming algorithms and even the in-memory algorithm HYPE, with respect to both cut-net and connectivity measures. This indicates that our proposed algorithm is a promising hypergraph partitioning tool to tackle the challenge posed by large-scale and dynamic data processing.
LBPMobileNet-based novel and simple leather image classification method
Authors: Varghese Anjli , Jawahar Malathy , Prince A. Amalin , Gandomi Amir H. 
Published: January 2025

AbstractThis article presents the design of a robust leather species identification technique. It aims to intertwine deep learning with leather image analysis. Hence, this work collects and analyzes large-scale leather image data for diverse learning. The data involve 7600 unique images with species-distinct and varied pore patterns from four species. It proposes a novel dual-stream architecture for accurate leather image classification. It is a fusion of local binary pattern-based texture analysis and MobileNet-based adaptive feature learning, hence the name LBPMobileNet. The former highlights the local structural pattern of an image, and the latter efficiently learns the species’ uniqueness. The dual-stream model analyzes two sources of images to provide more reliable and robust learning from different textured images. At the same time, it adopts two MobileNets to design a computationally efficient model. Thus, the proposed model utilizes limited resources and provides 96.45% accurate leather image classification. Further, the performance analysis affirms the generalization ability of the proposed model by predicting species from leather images with ideal and complex behavior. It also validates the robustness and computational efficiency of the proposed model with the state-of-the-art deep learning models. Thus, this study proves the relevance of local binary patterns, fused feature analysis, dual-stream architecture, and deep learning for efficient leather image analysis. It, thereby, assists the leather experts by developing an automatic and accurate species prediction method.
Inhaltliche und strukturelle Erwartungen an ein Tageshospiz
Authors: Kaiser Ulrich , Vehling-Kaiser Ursula , Fiedler Moritz , Hoffmann Ana , Chalupper Romina , Rechenmacher Michael , Kaiser Florian 
Published: January 2025

Zusammenfassung

Hintergrund
Tageshospize stellen eine neue Form der ambulanten palliativmedizinischen Versorgung in Deutschland dar. Trotz erster Empfehlungen existieren einheitliche Leitlinien zur inhaltlichen und strukturellen Ausrichtung noch nicht.

Ziel der Arbeit
Im Rahmen der IMPULS-Studie (Untersuchung zur Implementierung, Umsetzung und Nutzen eines Tageshospizes) wurden Patienten, Angehörige und Experten zu ihren Erwartungen bezogen auf die Institution Tageshospiz befragt, um die weitere Gestaltung und Umsetzung von Tageshospizen zu optimieren.

Material und Methoden
Es wurde ein Leitfaden für die Interviews mit offenen Fragen zu Definition, Zielen und inhaltlichen sowie organisatorischen Aspekten eines Tageshospizes entwickelt. Die Auswertung erfolgte mittels hermeneutischer Textinterpretation.

Ergebnisse
Elf qualitative Interviews wurden durchgeführt. Ein Tageshospiz sollte v. a. sozialer Isolation von Patienten entgegenwirken, Angehörige entlasten und die palliativ-pflegerische Versorgung sicherstellen. Bevorzugt werden Öffnungszeiten von 8 bis 16 Uhr, geschultes Personal, medizinische Betreuung, Barrierefreiheit, Einzel‑/Gruppenzimmer, ein ansprechendes Ambiente, ein Garten und ein ausgewogenes Beschäftigungsprogramm. Der Name „Tageshospiz“ wird kontrovers diskutiert. Wünschenswert wäre die Weitergabe von Informationen zum Angebot Tageshospiz über Hausärzte/Sozialdienste, digitale Öffentlichkeitsarbeit und flächendeckende Versorgung.

Diskussion
Patienten, Angehörige und Experten erwarten von einem Tageshospiz einen positiven Nutzen für dessen Gäste und deren Angehörige. Für die genaue Umsetzung des Projekts „Tageshospiz“ wurden im Rahmen der Interviews praktische Hinweise gegeben. Der weitere Aufbau und die Entwicklung von Tageshospizen bleiben mit Spannung abzuwarten und sollten durch Studien begleitet werden.
A comprehensive bibliometric analysis on social network anonymization: current approaches and future directions
Authors: Yazdanjue Navid , Yazdanjouei Hossein , Gharoun Hassan , Khorshidi Mohammad Sadegh , Rakhshaninejad Morteza , Amiri Babak , Gandomi Amir H. 
Published: January 2025

Abstract
In recent decades, social network anonymization has become a crucial research field due to its pivotal role in preserving users' privacy. However, the high diversity of approaches introduced in relevant studies poses a challenge to gaining a profound understanding of the field. In response to this, the current study presents an exhaustive and well-structured bibliometric analysis of the social network anonymization field. To begin our research, related studies from the period of 2007–2022 were collected from the Scopus Database and then preprocessed. Following this, the VOSviewer was used to visualize the network of authors’ keywords. Subsequently, extensive statistical and network analyses were performed to identify the most prominent keywords and trending topics. Additionally, the application of co-word analysis through SciMAT and the Alluvial diagram allowed us to explore the themes of social network anonymization and scrutinize their evolution over time. These analyses culminated in an innovative taxonomy of the existing approaches and anticipation of potential trends in this domain. To the best of our knowledge, this is the first bibliometric analysis in the social network anonymization field, which offers a deeper understanding of the current state and an insightful roadmap for future research in this domain.