bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoration and preservation of the authentic traditional housing model. Case study - the peasant house in the Danube Delta area
Authors: Pericleanu B D , Pericleanu M , Grămescu A M 
Published: April 2021

Abstract
The paper develops a new concept, relatively unique in approaching the concept of rehabilitation of the peasant house at the beginning of the XXI century, namely the traditional architecture of the Danube Delta as a system of integrated research, preservation of cultural and historical values. As it is known, the Vernacular Heritage Charter, ratified in 1999 in Mexico, draws attention to the fact that vernacular architecture around the world is valuable and requires protection, positive attitude in preserving, preserving and transmitting technologies, materials, architecture combined with authentic elements can even unique. This valuable built fund is increasingly subject to the pressures generated by urbanization, globalization (a phenomenon that affects local specificity) and lack of information or interest. The vernacular architecture of the Delta area was executed empirically, within the community using local materials, techniques and traditional crafts is what the Austrian American architect Bernard Rudofsky called it, in the title of his 1964 book, "Architecture without architects". The heritage reflected in the built environment of the villages in the Delta belongs to a type of vernacular architecture, and, of course, shares the general characteristics of the genre: a close communion with the natural landscape and the society in which it was "born". If we talk about contemporary ideology in architecture, in the context of very present discourses on sustainable development and sustainability (in absolutely all areas). The paper presents two approaches; high-tech, which supports the use of modern materials and advanced technology in construction and the low-tech approach, which aims at methods and techniques with low impact on the environment. The authors detail the concept of restoration corresponding to traditional materials and technologies.
Principles regarding integrated conservation of historical and archaeological sites to capitalize in the urban location
Authors: Simion A G , Gramescu A M , Pericleanu B D 
Published: April 2021

Abstract
The promotion in Romania of the integrated conservation of the historical / archaeological sites from the urban areas represents a vector of the recognition of the importance of the archaeological patrimony, as a source of non-renewable and public development. The starting point of the article is to analyse the state of the built heritage, of the historical and natural sites in the peninsular area of Constanta in order to propose solutions for conservation / rehabilitation and their enhancement. The article will outline some principles of major importance: the need for an in-depth historical and archaeological study that precedes any intervention or enhancement, the obligation to respect with the utmost rigor the authenticity of the remains, preserving their original substance, the requirement that public accessibility not harm the quality of the sites, as the case may be, their integration in the urban structure. Case study - the wall of the Tomis fortress.
Study on heat treatment and coating of copper screw female in friction pair of rock drill
Authors: Wang Y Y , Zhao M , Zhang X L 
Published: April 2021

Abstract
Aiming at the copper screw female parts of the rock drill friction pair that are made of tin bronze and easy to wear, the material, hardness, the metallographic structure and other comparative studies have conducted in-depth research on the formation mechanism of the application of thermal spraying technology on the copper spiral female parts of the rock drill product. The copper spiral female in the friction pair of the rock drill after heat treatment and thermal spraying has been tested on site by the customer. With better results, it is hoped that it can be used as a reference for the study of other friction pairs in rock drill products.
Optimization of diamond circular saw blade by vibration noise analysis
Authors: Wu T , Wang D , Zhao M 
Published: April 2021

Abstract
The vibration noise analysis and optimization of diamond circular saw blade is presented. The position of hole of the diamond circular saw blade matrix with diameter of 500 mm is established by analyzing the vibration and noise through experiment, and then making matrix topology optimization to the blade by ANSYS. The research content is divided into three parts. The noise analysis of diamond saw blade. Study on vibration characteristics of diamond saw blades. The optimization design of diamond saw blade. The study on the noise and vibration characteristics of diamond circular saw blade provides some reference for the design and technological parameter of blades. The successful application of the topology optimization has certain reference value to production and manufacturing of saw blades.
Study of two-phase transportation mode of liquefied natural gas through a pipeline by the gravitational method
Authors: Zhmakin V , Samoylov A 
Published: April 2021

Abstract
The given paper considers the choice of method and technology of liquefied natural gas transportation from an isothermal LNG storage facility via a pipeline to a transport cryogenic tank. Theoretical studies have been performed, including mathematical modeling of thermal and hydro-dynamic processes during the transportation of liquefied natural gas with partial evaporation through a pipeline. A new method for calculating the transportation of liquefied natural gas with partial evaporation through a pipeline using the gravitational method has been proposed in the paper.
Photocatalytic disinfection of bacteria under visible light irradiation by BiFeO3 photocatalyst
Authors: Daub N A , Aziz F , Mohd Zain N A , Lau W J , Yusof N , Salleh W N W , Jaafar J 
Published: April 2021

Abstract
BiFeO3 nanoparticles was synthesized by sol gel auto combustion. The as-synthesized BiFeO3 were characterized by X-ray diffraction (XRD), UV-Vis diffuse reflectance spectra (DRS) and Brunauer-Emmett-Teller (BET) analysis. The disinfection activities towards Gram-positive Staphylococcus aureus (S.aureus) were examined under visible light irradiation. The results showed a complete inactivation of 3 × 106 CFU/mL S.aureus was achieved within 20 min. The disruption of bacterial cell structure was observed by Transmission electron microscope (TEM). The cells were severely damaged after being exposed to BiFeO3 under visible light irradiation. Hence, the results demonstrated the potential application of perovskite-type photocatalyst, BiFeO3 in photocatalytic disinfection of various microorganisms.
The role of g-C3N4 in round-the-clock photocatalysis for POME
Authors: Razali N A M , Salleh W N W , Rosman N , Ismail H , Ahmad S Z N , Aziz F , Lau W J , Ismail A F 
Published: April 2021

Abstract
The main drawback of conventional palm oil mill effluent (POME) treatment is that the process is time and space-consuming. Besides, the treatment produces highly polluted wastewater that pollutes the environment if discharged directly. Photocatalytic process has significant potential to degrade recalcitrant organic pollutants and has recently attracted tremendous attention. However, current approaches mainly focus on visible light condition, which is still an ineffective treatment for POME. In this study, POME was successfully degraded using graphitic carbon nitride (g-C3N4) photocatalyst synthesised by calcination. The prepared photocatalyst was characterised by ultraviolet-visible diffuse reflectance (UV-Vis DRS) spectroscopy and scanning electron microscopy (SEM). The SEM results revealed the morphology of g-C3N4 photocatalyst. g-C3N4 could act as a visible-light-driven (VLD) photocatalyst with the highest photocatalytic efficiency of 71% under visible light. The present work highlights the potential of g-C3N4 towards the degradation of POME under visible light and dark condition. The highly enhanced photocatalytic performance is attributed to g-C3N4, but it does not work well in round-the-clock photocatalysis. However, g-C3N4 can work as the band alignment to drive separate photogenerated charge carriers, leading to effective photocatalytic degradation. g-C3N4 photocatalyst may be considered as an ideal candidate for treating POME.
Study on the effect of air gap on physico-chemical and performance of PVDF hollow fibre membrane
Authors: Zakria H S , Othman M H D , Kamaludin R , Jilani A 
Published: April 2021

Abstract
Polyvinylidene fluoride (PVDF) was chosen in this study as the main material in fabricating membrane due to its excellent chemical resistance and good thermal stability. Combination of triethyl phosphate (TEP) with DMAc produce better structure of membrane which safer and provide high mechanical strength for membrane. Surface modified PVDF hollow fibre membrane (HFM) was prepared using dry-wet spinning technique by varying air gap namely 10 cm, 20 cm and 30 cm. The morphology was evaluated using scanning electron microscopy (SEM), atomic force microscopy (AFM), mercury intrusion porosimetry (MIP), contact angle, tensile test and performing water flux testing. From the characterization data, PVDF HFM with 3 wt.% PEG 400, HFM 3-10 and HFM 3-20 referred as microfiltration membrane with pore size range 0.1-0.8 µm. While, HFM 3-30 act as ultrafiltration membrane with pore size ranging 0.01-0.1 µm. Experimental results revealed that by increasing the air gap from 10 cm to 30 cm, the porosity and finger-like length decreased due to the higher elongational stress that shift the pores from broad to narrow. Thus, PVDF HFM at 10 cm air gap, HFM 3-10 achieve the highest water flux due to the higher porosity, longer finger-like length and hydrophilicity achieved. The modified HFM at shorter air gap was found to be a promising membrane structure for excellence water performance and eco-friendly to environment.
Retraction: Lean manufacturing analysis to reduce waste on production process of fan products (IOP Conf. Ser.: Mater. Sci. Eng.
308 012004)
Authors: Siregar I , Nasution A A , Andayani U , Sari R M , Syahputri K , Anizar  
Published: April 2021

IOP Publishing Limited ("IOPP") is retracting this paper at the request of the author, who has stated that the work contains material or data without authorisation for use.
Retraction published: 27 April 2021
Propagation of priors for more accurate and efficient spectroscopic functional fits and their application to ferroelectric hysteresis
Authors: Creange N , Kelley K P , Smith C , Sando D , Paull O , Valanoor N , Somnath S , Jesse S , Kalinin S V , Vasudevan R K 
Published: April 2021

Abstract
Multi-dimensional spectral-imaging is a mainstay of the scanning probe and electron microscopies, micro-Raman, and various forms of chemical imaging. In many cases, individual spectra can be fit to a specific functional form, with the model parameter maps, providing direct insight into material properties. Since spectra are often acquired across a spatial grid of points, spatially adjacent spectra are likely to be similar to one another; yet, this fact is almost never used when considering parameter estimation for functional fits. On datasets tried here, we show that by utilizing proximal information, whether it be in the spatial or spectral domains, it is possible to improve the reliability and increase the speed of such functional fits by ∼2–3×, as compared to random priors. We explore and compare three distinct new methods: (a) spatially averaging neighborhood spectra, and propagating priors based on functional fits to the averaged case, (b) hierarchical clustering-based methods where spectra are grouped hierarchically based on response, with the priors propagated progressively down the hierarchy, and (c) regular clustering without hierarchical methods with priors propagated from fits to cluster means. Our results highlight that utilizing spatial and spectral neighborhood information is often critical for accurate parameter estimation in noisy environments, which we show for ferroelectric hysteresis loops acquired on a prototypical PbTiO3 thin film with piezoresponse spectroscopy. This method is general and applicable to any spatially measured spectra where functional forms are available. Examples include exploring the superconducting gap with tunneling spectroscopy, using the Dynes formula, or current–voltage curve fits in conductive atomic force microscopy mapping. Here we explore the problem for ferroelectric hysteresis, which, given its large parameter space, constitutes a more difficult task than, for example, fitting current–voltage curves with a Schottky emission formula (Chiu 2014 Adv. Mater. Sci. Eng.
2014 578168).
Abdominal Laser Lipolysis Using a Microprocessor-Controlled Robotic Arm With Noncontact Heating and Cooling
Authors: Fiala Thomas 
Published: April 2021

Abstract

Background
A novel FDA-cleared device uses a 1064-nm laser to noninvasively induce apoptosis for lipolysis of subcutaneous abdominal fat while maintaining comfortable skin temperatures with a proprietary jet cooling system (eon; Dominion Aesthetic Technologies, Inc., San Antonio, TX). A programmable articulated robotic arm moves the treatment head without any subject contact, maintaining an appropriate 3-dimensional treatment path, compensating for patient movement.

Objectives
The goal of this prospective, single center, open-label study was to demonstrate the safety and effectiveness of this device for reducing subcutaneous abdominal fat when operated with an updated power delivery curve.

Methods
Male and female subjects with Fitzpatrick skin types I to VI (N = 26) were treated. Four abdominal zones up to 150 cm2 each, customized in size and location for body habitus, were treated. Each zone underwent a single 20-minute treatment session. Follow-up visits occurred after 6 and 12 weeks. A standardized protocol was used to obtain ultrasound measurement of subcutaneous abdominal fat thickness, abdominal circumference, reported patient satisfaction and digital images.

Results
The mean treatment area was 378.5 cm2. At Week 12, there was a 21.6% or 6.3 mm mean reduction in abdominal subcutaneous fat thickness and a 4.1-cm (1.6-inch) mean reduction in abdominal circumference. Most subjects (84.6%) were satisfied or very satisfied with their results. The mean pain score was 2.5 on an 11-point ordinal scale. There were no nonresponders. Only 2 adverse events were noted: mild transient erythema (n = 1, 3.8%) and localized subcutaneous firmness (n = 1, 3.8%) which resolved without intervention within 12 weeks.

Conclusions
This contact-free device is safe and effective for reducing subcutaneous abdominal fat and represents an improvement on the prior treatment protocol.

Level of Evidence: 4
DIAmeter: matching peptides to data-independent acquisition mass spectrometry data
Authors: Lu Yang Young , Bilmes Jeff , Rodriguez-Mias Ricard A , Villén Judit , Noble William Stafford 
Published: April 2021

Abstract

Motivation
Tandem mass spectrometry data acquired using data independent acquisition (DIA) is challenging to interpret because the data exhibits complex structure along both the mass-to-charge (m/z) and time axes. The most common approach to analyzing this type of data makes use of a library of previously observed DIA data patterns (a ‘spectral library’), but this approach is expensive because the libraries do not typically generalize well across laboratories.

Results
Here, we propose DIAmeter, a search engine that detects peptides in DIA data using only a peptide sequence database. Although some existing library-free DIA analysis methods (i) support data generated using both wide and narrow isolation windows, (ii) detect peptides containing post-translational modifications, (iii) analyze data from a variety of instrument platforms and (iv) are capable of detecting peptides even in the absence of detectable signal in the survey (MS1) scan, DIAmeter is the only method that offers all four capabilities in a single tool.

Availability and implementation
The open source, Apache licensed source code is available as part of the Crux mass spectrometry analysis toolkit (http://crux.ms).

Supplementary information
Supplementary data are available at Bioinformatics online.
TUGDA: task uncertainty guided domain adaptation for robust generalization of cancer drug response prediction from in vitro to in vivo settings
Authors: Peres da Silva Rafael , Suphavilai Chayaporn , Nagarajan Niranjan 
Published: April 2021

Abstract

Motivation
Large-scale cancer omics studies have highlighted the diversity of patient molecular profiles and the importance of leveraging this information to deliver the right drug to the right patient at the right time. Key challenges in learning predictive models for this include the high-dimensionality of omics data and heterogeneity in biological and clinical factors affecting patient response. The use of multi-task learning techniques has been widely explored to address dataset limitations for in vitro drug response models, while domain adaptation (DA) has been employed to extend them to predict in vivo response. In both of these transfer learning settings, noisy data for some tasks (or domains) can substantially reduce the performance for others compared to single-task (domain) learners, i.e. lead to negative transfer (NT).

Results
We describe a novel multi-task unsupervised DA method (TUGDA) that addresses these limitations in a unified framework by quantifying uncertainty in predictors and weighting their influence on shared feature representations. TUGDA’s ability to rely more on predictors with low-uncertainty allowed it to notably reduce cases of NT for in vitro models (94% overall) compared to state-of-the-art methods. For DA to in vivo settings, TUGDA improved over previous methods for patient-derived xenografts (9 out of 14 drugs) as well as patient datasets (significant associations in 9 out of 22 drugs). TUGDA’s ability to avoid NT thus provides a key capability as we try to integrate diverse drug-response datasets to build consistent predictive models with in vivo utility.

Availabilityand implementation
https://github.com/CSB5/TUGDA.

Supplementary information
Supplementary data are available at Bioinformatics online.
Regional Networks of Biological Field Stations to Study Climate Change
Authors: Stuble Katharine L , Des Roches Simone , Ambrose Anthony , Brown Kevin C , Cooper Helen , Hilton Timothy , Sinervo Barry , Fox Laurel R 
Published: April 2021

AbstractField stations are platforms for documenting patterns and processes in ecosystems and are critical for understanding how anthropogenic climate change reshapes nature. Although networks of field stations have been used to identify patterns at continental to global scales, these broad, sparsely distributed networks miss variation in climate change at local and regional scales. We propose that regional-scale research networks are essential for addressing the myriad of ecological and evolutionary challenges—including management and mitigation options—that cannot be answered by more broadly distributed networks or by individual field sites. We discuss our experiences leveraging natural areas throughout California at the Institute for the Study of Ecological and Evolutionary Climate Impacts. We then explore benefits and challenges of networking research at spatial scales congruent with regional patterns of climate variation and climate change, the challenges of sustained infrastructure and research support, and opportunities for future regional-scale research networks.
O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC)
Authors: Thaventhiran A , Thiemermann C , Brohi K , Tremoleda JL , Davenport RA 
Published: April 2021

Abstract

Introduction
In the UK, 17,000 people die from injury each year, with uncontrolled bleeding the most significant cause of preventable mortality. Acute Traumatic Coagulopathy (ATC) exacerbates bleeding through the failure of blood-clotting with accelerated clot breakdown that mechanistically is driven by activated Protein C (aPC). No targeted therapy to treat the underlying cause of ATC exists with treatment limited to blood component resuscitation and antifibrinolytic drugs to prevent premature clot breakdown.

Method
Two hundred fifty-four bleeding trauma patients had Factor V and aPC measured on arrival and during resuscitation. A preclinical ATC model was used to test the novel therapeutic recombinant Factor V (rFV), which is resistant to aPC mediated cleavage. Mice underwent combined injury and pressure controlled-blood loss with intervention at 30-minutes to represent a clinically relevant model. Coagulopathy was measured by ROTEM and biomarkers of coagulation/fibrinolysis.

Result
Admission levels of FV were 38% lower (83 vs 134u/dL, p&lt;0.0001), deteriorated during resuscitation to 65% of normal after transfusion of eight RBC units and were inversely related to aPC levels. Compared to vehicle, animals treated with rFV had reduced coagulopathy (Clot Strength at 5 minutes: 31 vs 24mm, p&lt;0.01) and significantly improved survival (80% vs 44%, p≤ 0.001).

Conclusion
FV falls significantly during bleeding in trauma patients and in the murine model, rFV improved coagulation suggesting it may represent a potential therapeutic target for ATC.

Take-home message
Directly targeting the cause of ATC represents a novel therapeutic strategy in trauma and may improve survival after major haemorrhage by directly improving clot function.
O3: EVALUATION OF A 3D PRINTED BIO-ARTIFICIAL MUSCLE-ORGANOID FOR TRAUMA RESEARCH
Authors: Staruch RMT , Spear AM , Edwards J , Rickard R , Thompson M 
Published: April 2021

Abstract

Introduction
Organoid models serve as a robust platform for investigating injury and disease in vitro. Currently, representative models of injury are lacking to investigate the effects of traumatic damage to organs and tissues. Here we describe a three-dimensional in vitro model of high strain rate loading seen in traumatic blast injury.

Method
3D printing resins were tested for Young's Modulus & Poisson Ratio using a universal testing Organoids were then loaded into a 3D Printed bioreactor for high strain rate loading using a split Hopkinson pressure bar device. machine and digital image. Euler beam theory was used to evaluate post deflection. C2C12 myoblasts were seeded in fibrin hydrogels around 3D printed posts using a custom designed jig. High strain rate loading was applied to constructs, then qPCR & Fluorescent Live/Dead staining was utilised to demonstrate cell alignment and myotube formation.

Result
Young's modulus of Flexible resin was 11.51Mpa. Differentiated C2C12 myoblasts were capable of alignment between posts and expression of key markers of differentiation shown by qPCR & imaging. MYH5, MYH2 & MYH1 all had a &gt; 1.5 old increase in expression compared to undifferentiated controls. Organoids were capable of survival in bioreactor casings for over 24 hours and were intact after application of high strain rate loading.

Conclusion
This work demonstrates the first use of a 3D printed organoid in vitro model to investigate high strain rate loading for trauma research. This organoid is capable of high throughput analysis to facilitate genomic and protein level expression analysis.

Take-home message
This work demonstrates the first use of a 3D printed organoid in vitro model to investigate high strain rate loading for trauma research.