bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Lipid Bilayer on the GPCR Structure: Comparison of All-Atom Lipid Force Fields
Authors: Mahmood Md Iqbal , Yamashita Takefumi 
Published: September 2021

Abstract
Lipid bilayers affect the structure and dynamics of membrane proteins significantly. In this study, to examine three AMBER-compatible force fields (GAFFlipid, Slipids, and Lipid14), we conducted molecular dynamics (MD) simulations of β2 adrenergic receptor (β2AR) embedded in the palmitoyl-oleoyl-phosphatidyl-choline (POPC) bilayer. We found that the lipid force field affected protein structures (e.g., stability of the ionic lock) largely, even though they were distant from lipids. For example, while the R131-E268 salt bridge (ionic lock), which is involved in protein activation, opened frequently in GAFFlipid and Lipid14 systems, it mostly remained closed in the Slipids system. This difference should be attributed to the difference in the interaction energy between β2AR and POPC bilayer; this energy was much smaller in the Slipids system than in the GAFFlipid and Lipid14 systems.
Factors Associated with the Willingness to Perform a Physical Employment Standard in Probation Officers
Authors: GIULIANI-DEWIG HAYDEN K. , KERR ZACHARY Y. , REGISTER-MIHALIK JOHNA K. , MOTA JACOB A. , RYAN ERIC D. 
Published: September 2021

ABSTRACT

Purpose
This study examined worker characteristics and behaviors and the perceived importance of job-related tasks associated with the willingness to perform a proposed probation officer physical ability test (PROPAT).

Methods
North Carolina probation officers (N = 1213, 46.2% female, 39.8 ± 10.1 yr, 30.7 ± 6.6 kg·m−2) completed a survey including demographics, health history, and job-related tasks. A multivariable logistic regression model estimated the odds of being willing to perform the PROPAT. Adjusted odds ratios (ORadjusted) with 95% confidence intervals (CI) were calculated, with those excluding 1.00 deemed statistically significant.

Results
The majority (72%) of probation officers were willing to perform the PROPAT. Being male (compared with female) (ORadjusted = 1.50, 95% CI = 1.12–2.02) and having moderate (ORadjusted = 1.51, 95% CI = 1.10–2.08) and high physical activity status (ORadjusted = 2.89, 95% CI = 1.97–4.28) (compared with low) increased the odds of being willing to perform the PROPAT. Additionally, reporting a greater importance of tasks, including running to pursue a suspect (TASKRUN, 1-unit increase, ORadjusted = 1.25, 95% CI = 1.10–1.43) and dragging an unresisting person (TASKDRAG, 1-unit increase, ORadjusted = 1.16, 95% CI = 1.01–1.32), increased the odds of being willing to perform the PROPAT. Increasing age (1-yr increase, ORadjusted = 0.96, 95% CI = 0.94–0.98), class II (ORadjusted = 0.45, 95% CI = 0.28–0.71) and class III obesity (compared with normal weight, ORadjusted = 0.55, 95% CI = 0.32–0.93), and a previous musculoskeletal injury (ORadjusted = 0.57, 95% CI = 0.35–0.93) all decreased the odds of being willing to perform the PROPAT.

Conclusions
These results suggest being older, previously injured, obese (body mass index ≥ 35 kg·m−2), and less active is associated with being less willing to participate in the PROPAT, whereas males and reporting a higher importance of the TASKRUN and TASKDRAG activities is associated with being more willing to participate in the PROPAT. Departments can use these findings to identify feasible strategies (e.g., education and physical training) to improve the implementation of physical employment standards.
One-stop preoperative assessment of renal vessels for living donors with 3.0 T non-contrast-enhanced magnetic resonance angiography: compared with computerized tomography angiography and surgical results
Authors: Li Xiaotian , Xia Fangjie , Chen Lihua , Zhang Xiaodong , Mo Chunbai , Shen Wen 
Published: September 2021

Objective: The study was to investigate the feasibility and accuracy of assessment for living renal donors before transplantation by using 3.0 T non-contrast-enhanced magnetic resonance angiography (NCE-MRA). Methods: 30 renal donors were investigated and underwent computed tomography angiography (CTA) and 3.0 T NCE-MRA before nephrectomy. Two radiologists independently assessed arterial and venous anatomy and potential kidney lesions. The image quality score, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), diameters and lengths of renal arteries and veins were compared between CTA and NCE-MRA. Imaging findings were compared with the surgical results served as reference standard. Agreement was assessed using κ test. The Wilcoxon test and paired sample t test were used for statistically significant differences. Results: The results of image quality score for renal arteries and veins were highly consistent between the two radiologists in NCE-MRA (p < 0.001). There was no significant difference in the scores of renal arterial and venous branches between NCE-MRA and CTA (p > 0.05). The SNR and CNR of renal vessels were higher than CTA (p < 0.001). There were no statistically significant differences in the length of renal vessels measured by the two methods (p > 0.05), and the diameter was smaller than that of CTA (p < 0.05). The detection of normal renal arteries and early branches by both examination techniques was consistent with intraoperative findings. Both methods showed good consistency between the anatomical variation of renal vein and the intraoperative diagnosis (p < 0.001). Conclusion: 3.0 T NCE-MRA can be used for evaluation of main renal arteries and veins with high accuracy for anatomy and variation classification, and can be used for pre-operative vascular evaluation of living donor kidney transplantation. Advances in knowledge: 3.0 T NCE-MRA can be used for evaluation of main renal arteries and veins with high accuracy for anatomy and variation classification, and can be used for pre-operative vascular evaluation of living donor kidney transplantation.
Diagnostic accuracy of a urine dipstick for detecting albuminuria in hypertensive patients
Authors: Panta Phornwipa , Techakehakij Win 
Published: September 2021

Background: Screening for albuminuria is generally recommended among patients with hypertension. While the urine dipstick is commonly used for screening urine albumin, there is little evidence about its diagnostic accuracy among these patients in Thailand. This study aimed to assess the diagnostic accuracy of a dipstick in Thai hypertensive patients for detecting albuminuria. Methods: This study collected the data of 3,067 hypertensive patients, with the results of urine dipstick and urine albumin-to-creatinine ratio (ACR) from random single spot urine being examined in the same day at least once, at Lampang Hospital, Thailand, during 2018. For ACR, a reference standard of ≥ 30 mg/g was applied to indicate the presence of albuminuria. Results: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value of the trace result from dipsticks were 53.6%, 94.5%, 86.5%, and 75.5%, respectively. The area under the receiver operating characteristic curve of the dipstick was 0.748. Conclusion: Using the dipstick for screening albuminuria among hypertensive patients should not be recommended for mass screening due to its low sensitivity. In response to high PPV, a trace threshold of the dipstick may be used to indicate presence of albuminuria.
Antecedents of generation Z towards digitalisation. A PLS-SEM analysis
Authors: Chan Kar Hoong , Ng Tuan Hock , Tay Lee Ying , Teh Chiu Yu 
Published: September 2021

Background: The Covid-19 pandemic has forced businesses in the direction of technology development. In particular, financial institutions have started the digital transformation, embracing the usage of artificial intelligence. In this respect, consumers’ willingness to adopt artificial intelligence in finance, appears to have relevance to current efforts to enhance the efficiency and effectiveness of the financial system. This study aims to better comprehend the antecedents towards the intention to adopt artificial intelligence in financial services among Generation Z, with the use of the Technology Acceptance Model. Methods: In this study, questionnaires were used to collect data from 150 male and female Malaysian undergraduates. Partial Least Squares-Structural Equation Modelling was employed to analyse the data. Results: Perceived ease of use and attitude, positively influenced the adoption of artificial intelligence in financial services. Conclusion: The results have suggested the improvement in user interface, information and activities to encourage generation Z to adopt artificial intelligence in financial services.
Racial and Ethnic Disparities in Discharge Opioid Prescribing From a Hospital Medicine Service
Authors: Rambachan Aksharananda , Fang Margaret C , Prasad Priya , Iverson Nicholas 
Published: September 2021

BACKGROUNDDifferential opioid prescribing patterns have been reported in non‐White patient populations. However, these disparities have not been well described among hospitalized medical inpatients.OBJECTIVETo describe differences in opioid prescribing patterns among inpatients discharged from the general medicine service based on race/ethnicity.DESIGN, SETTING, AND PARTICIPANTSFor this retrospective study, we performed a multivariable logistic regression for patient race/ethnicity and whether patients received an opioid prescription at discharge and a negative binomial regression for days of opioids prescribed at discharge. The study included all 10,953 inpatients discharged from the general medicine service from June 2012 to November 2018 at University of California San Francisco Medical Center who received opioids during the last 24 hours of their hospitalization.MAIN OUTCOMES AND MEASURESWe examined two primary outcomes: whether a patient received an opioid prescription at discharge, and, for patients prescribed opioids, the number of days dispensed.RESULTSCompared with White patients, Black patients were less likely to receive an opioid prescription at discharge (predicted population rate of 47.6% vs 50.7%; average marginal effect [AME], −3.1%; 95% CI, −5.5% to −0.8%). Asian patients were more likely to receive an opioid prescription on discharge (predicted population rate, 55.6% vs 50.7%; AME, +4.9; 95% CI, 1.5%‐8.3%). We also found that Black patients received a shorter duration of opioid days compared with White patients (predicted days of opioids on discharge, 15.7 days vs 17.8 days; AME, −2.1 days; 95% CI, −3.3 to −0.9).CONCLUSIONBlack patients were less likely to receive opioids and received shorter courses at discharge compared with White patients, adjusting for covariates. Asian patients were the most likely to receive an opioid prescription.
Increasingly expanded future risk of dengue fever in the Pearl River Delta, China
Authors: Wu Wei , Ren Hongyan , Lu Liang 
Published: September 2021

Background
In recent years, frequent outbreaks of dengue fever (DF) have become an increasingly serious public health issue in China, especially in the Pearl River Delta (PRD) with fast socioeconomic developments. Previous studies mainly focused on the historic DF epidemics, their influencing factors, and the prediction of DF risks. However, the future risks of this disease under both different socioeconomic development and representative concentration pathways (RCPs) scenarios remain little understood.

Methodology and principal findings
In this study, a spatial dataset of gross domestic product (GDP), population density, and land use and land coverage (LULC) in 2050 and 2070 was obtained by simulation based on the different shared socioeconomic pathways (SSPs), and the future climatic data derived from the RCP scenarios were integrated into the Maxent models for predicting the future DF risk in the PRD region. Among all the variables included in this study, socioeconomics factors made the dominant contribution (83% or so) during simulating the current spatial distribution of the DF epidemics in the PRD region. Moreover, the spatial distribution of future DF risk identified by the climatic and socioeconomic (C&S) variables models was more detailed than that of the climatic variables models. Along with global warming and socioeconomic development, the zones with DF high and moderate risk will continue to increase, and the population at high and moderate risk will reach a maximum of 48.47 million (i.e., 63.78% of the whole PRD) under the RCP 4.5/SSP2 in 2070.

Conclusions
The increasing DF risk may be an inevitable public health threat in the PRD region with rapid socioeconomic developments and global warming in the future. Our results suggest that curbs in emissions and more sustainable socioeconomic growth targets offer hope for limiting the future impact of dengue, and effective prevention and control need to continue to be strengthened at the junction of Guangzhou-Foshan, north-central Zhongshan city, and central-western Dongguan city. Our study provides useful clues for relevant hygienic authorities making targeted adapting strategies for this disease.
Evaluation of reporting quality of randomized controlled trials in patients with COVID-19 using the CONSORT statement
Authors: Yin Yuhuan , Shi Fugui , Zhang Yiyin , Zhang Xiaoli , Ye Jianying , Zhang Juxia 
Published: September 2021

ObjectiveTo evaluate the reporting quality of randomized controlled trials (RCTs) regarding patients with COVID-19 and analyse the influence factors.MethodsPubMed, Embase, Web of Science and the Cochrane Library databases were searched to collect RCTs regarding patients with COVID-19. The retrieval time was from the inception to December 1, 2020. The CONSORT 2010 statement was used to evaluate the overall reporting quality of these RCTs.Results53 RCTs were included. The study showed that the average reporting rate for 37 items in CONSORT checklist was 53.85% with mean overall adherence score of 13.02±3.546 (ranged: 7 to 22). The multivariate linear regression analysis showed the overall adherence score to the CONSORT guideline was associated with journal impact factor (P = 0.006), and endorsement of CONSORT statement (P = 0.014).ConclusionAlthough many RCTs of COVID-19 have been published in different journals, the overall reporting quality of these articles was suboptimal, it can not provide valid evidence for clinical decision-making and systematic reviews. Therefore, more journals should endorse the CONSORT statement, authors should strictly follow the relevant provisions of the CONSORT guideline when reporting articles. Future RCTs should particularly focus on improvement of detailed reporting in allocation concealment, blinding and estimation of sample size.
Assessed and perceived oral health of older people who visit the dental practice, an exploratory cross-sectional study
Authors: Bots-VantSpijker Pieternella C. , van der Maarel-Wierink Claar D. , Schols Jos M. G. A. , Bruers Josef J. M. 
Published: September 2021

Objectives
To assess the oral health of older people who visit the community dental practice from both the dentists’ and the patients’ perspective.

Materials and methods
In this exploratory cross-sectional study the oral health of Dutch community dwelling older people was assessed. A representative sample of general dental practitioners was asked to randomly and prospectively select one older patient and describe this patient using a specially-developed registration form; in addition the patient was requested to complete a questionnaire. The oral health of older people was described from the perspective of the dentists and the perspective of the older people themselves based on the definition of oral health from the World Dental Federation (FDI].
Relations between oral health of older people and dentist and older patient characteristics were analysed using Spearman’s rank correlation coefficient (rho) and an ordinal regression model.

Results
In total, 923 dentists were asked to participate in the study; data was available for 39.4% dentist-patient pairs. Dentists assessed the oral health of older patients as good or acceptable in 51.4% of the cases while this was the case in 76.2% of older patients themselves. The assessment of the dentist gets more negative with high treatment intensity and with older patients having certain diseases and more medication, while the assessment is more positive for older patients who visit the dentist on a regular basis.
Older people’s assessment of their oral health gets more negative by being female and with high treatment intensity, having certain diseases and higher use of medication.

Conclusions and clinical relevance
Chronically illness as expressed by the number of diseases and the use of medication, seems to be a risk factor for poor oral health.
Older patients themselves assess their oral health differently, mostly more positive, than their dentist.
Census tract socioeconomic indicators and COVID-19-associated hospitalization rates—COVID-NET surveillance areas in 14 states, March 1–April 30, 2020
Authors: Wortham Jonathan M. , Meador Seth A. , Hadler James L. , Yousey-Hindes Kimberly , See Isaac , Whitaker Michael , O’Halloran Alissa , Milucky Jennifer , Chai Shua J. , Reingold Arthur , Alden Nisha B. , Kawasaki Breanna , Anderson Evan J. , Openo Kyle P. , Weigel Andrew , Monroe Maya L. , Ryan Patricia A. , Kim Sue , Reeg Libby , Lynfield Ruth , McMahon Melissa , Sosin Daniel M. , Eisenberg Nancy , Rowe Adam , Barney Grant , Bennett Nancy M. , Bushey Sophrena , Billing Laurie M. , Shiltz Jess , Sutton Melissa , West Nicole , Talbot H. Keipp , Schaffner William , McCaffrey Keegan , Spencer Melanie , Kambhampati Anita K. , Anglin Onika , Piasecki Alexandra M. , Holstein Rachel , Hall Aron J. , Fry Alicia M. , Garg Shikha , Kim Lindsay 
Published: September 2021

Objectives
Some studies suggested more COVID-19-associated hospitalizations among racial and ethnic minorities. To inform public health practice, the COVID-19-associated Hospitalization Surveillance Network (COVID-NET) quantified associations between race/ethnicity, census tract socioeconomic indicators, and COVID-19-associated hospitalization rates.

Methods
Using data from COVID-NET population-based surveillance reported during March 1–April 30, 2020 along with socioeconomic and denominator data from the US Census Bureau, we calculated COVID-19-associated hospitalization rates by racial/ethnic and census tract-level socioeconomic strata.

Results
Among 16,000 COVID-19-associated hospitalizations, 34.8% occurred among non-Hispanic White (White) persons, 36.3% among non-Hispanic Black (Black) persons, and 18.2% among Hispanic or Latino (Hispanic) persons. Age-adjusted COVID-19-associated hospitalization rate were 151.6 (95% Confidence Interval (CI): 147.1–156.1) in census tracts with >15.2%–83.2% of persons living below the federal poverty level (high-poverty census tracts) and 75.5 (95% CI: 72.9–78.1) in census tracts with 0%–4.9% of persons living below the federal poverty level (low-poverty census tracts). Among White, Black, and Hispanic persons living in high-poverty census tracts, age-adjusted hospitalization rates were 120.3 (95% CI: 112.3–128.2), 252.2 (95% CI: 241.4–263.0), and 341.1 (95% CI: 317.3–365.0), respectively, compared with 58.2 (95% CI: 55.4–61.1), 304.0 (95%: 282.4–325.6), and 540.3 (95% CI: 477.0–603.6), respectively, in low-poverty census tracts.

Conclusions
Overall, COVID-19-associated hospitalization rates were highest in high-poverty census tracts, but rates among Black and Hispanic persons were high regardless of poverty level. Public health practitioners must ensure mitigation measures and vaccination campaigns address needs of racial/ethnic minority groups and people living in high-poverty census tracts.
The MoveStrong program for promoting balance and functional strength training and adequate protein intake in pre-frail older adults: A pilot randomized controlled trial
Authors: Rodrigues Isabel B. , Wang Ellen , Keller Heather , Thabane Lehana , Ashe Maureen C. , Brien Sheila , Cheung Angela M. , Funnell Larry , Jain Ravi , Loong Desmond , Isaranuwatchai Wanrudee , Milligan Jamie , Mourtzakis Marina , Papaioannou Alexandra , Straus Sharon , Weston Zachary J. , Giangregorio Lora M. 
Published: September 2021

Background
Balance and functional strength training can improve muscle strength and physical functioning outcomes and decrease the risk of falls in older adults. To maximize the benefits of strength training, adequate protein intake is also important. However, the number of older individuals that consume enough protein or routinely engage in strength training remains low at less than 5% and even lower for activities that challenge balance. Our primary aim was to assess the feasibility of implementing a model (MoveStrong) of service delivery to teach older adults about balance and functional strength training and methods to increase protein intake.

Methods
This study was a closed cohort stepped wedge randomized controlled trial. We recruited individuals ≥60 years considered pre-frail or frail with at least one chronic condition who were not currently engaging in regular strength training from Northern (rural) and Southern (urban) Ontario sites in Canada. The primary outcome was feasibility of implementation, defined by recruitment, retention, and adherence, and safety (defined by monitoring adverse events). We also reported participants’ and providers’ experience with MoveStrong, adaptations to the model based on participant’s and provider’s experience, and program fidelity.

Results
We recruited 44 participants to the study and the average adherence rate was 72% with a retention of 71%. The program had a high-fidelity score. One person experienced a fall-related injury during exercise, while two other participants reported pain during certain activities. Five individuals experienced injuries or health problems that were not related to the program. Suggestions for future trials include modifying some exercises, exploring volunteer assistance, increasing the diversity of participants enrolled, and considering a different study design.

Conclusions
Our pilot trial demonstrates the feasibility of recruitment and adherence for a larger multisite RCT of balance and functional strength training with attention to protein intake in pre-frail and frail older adults.
Etiologies and 12-month mortality in patients with isolated involuntary weight loss at a rapid diagnostic unit
Authors: Aligué Jordi , Vicente Mireia , Arnau Anna , Trapé Jaume , Martínez Eva , Bonet Mariona , Abril Andrés , El Boutrouki Omar , Ordeig Roser , Ruiz Domingo , Ordeig Josep , San José Antonio 
Published: September 2021

Background
Numerous studies on involuntary weight loss (IWL) have been published since the 1980s, although most of them have included small samples of patients with specific symptoms. The aim of the present study was to determine the causes, demographic and clinical characteristics and mortality at 12 months in patients attended at a rapid diagnostic unit (RDU) for isolated IWL.

Methods
A single-center retrospective observational study including all patients presenting to the RDU for isolated IWL between 2005 and 2013. The following data were recorded: demographic and clinical variables, results of complementary tests (blood tests, x-rays, computed tomography scan and digestive endoscopy), main diagnosis and vital status at 12 months.

Results
Seven hundred and ninety-one patients met the criteria for IWL. Mean age was 67.9 years (SD 4.7), 50.4% were male and mean weight loss was 8.3 kg (SD 4.7). The cause for IWL was malignant disease in 23.6% of patients, non-malignant organic disease in 44.5%, psychiatric disorder in 29.0% and unknown in 3.2%. Overall mortality at 12 months was 18.6% (95%CI: 16.1–21.6). The mortality rate was highest in the group with malignancy (61.1%; 95%CI: 54.2–68.2).

Conclusions
Almost a quarter of all patients attended at the RDU for IWL were diagnosed with cancer. Mortality at 12 months was higher in this group than in the other three. Malignancy should therefore be ruled out during the first visit for patients attended for IWL.