bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding collaboration in short food supply chains: a focus on collaborative relationships, interaction mechanisms and relational benefits
Authors: Stoeva S. , Van Gompel R. , Van den Bossche L. , Rogge E. , Slavova P. , Grivins M. , Mileiko I. 
Published: December 2024

AbstractThe article provides an original conceptual framework to advance the knowledge of short food supply chains (SFSCs) collaboration by bridging supply chain management approaches with empirical evidence from the agri-food sector. Through an in-depth analysis of 14 initiatives across Europe, it explores the multi-faceted nature of SFSCs collaboration, revealing a complex interplay between collaborative relationships, interaction mechanisms, and relational benefits. By identifying seven key interaction mechanisms—information sharing, decision synchronisation, goal congruence, incentive alignment, resource sharing, joint knowledge creation, and collaborative communication—the article shows how these mechanisms generate both tangible and intangible relational benefits, including fair pricing, reduced transaction costs, enhanced market knowledge, technological skills, and stronger community engagement. The findings demonstrate that SFSCs collaborations operate as dynamic ecosystems characterised by complex interdependencies among diverse actors. This diversity extends beyond traditional business-to-business (B2B) models to include business-to-consumer (B2C), consumer-to-business (C2B), and hybrid business-to-business-to-consumer (B2B2C) relationships. These varied collaborative structures facilitate mutual learning, innovation, and value co-creation, crucial for the resilience and adaptability of local food systems. The presence of robust interaction mechanisms is essential for fostering effective partnerships and generating relational benefits, even if not all mechanisms are consistently present in every type of collaborative relationships.
Muscle architecture of the medial gastrocnemius during growth
Authors: Mogi Yasuyoshi 
Published: December 2024

Abstract
Background
Muscle architecture is closely related to muscle function. Increased knowledge of growth changes in muscle architecture will provide insights into the development of human movements and sports performance during the growth period. However, it is unclear how the muscle architecture of the medial gastrocnemius (MG) grows. This study examined the effects of growth on the muscle architecture of MG.

Methods
The brightness-mode ultrasonography technique was used to measure the muscle thickness, pennation angle, and fascicle length of MG in 146 Japanese boys aged to 6.2 − 17.9 years. The relative muscle thickness was calculated by dividing the absolute muscle thickness by body mass1/3. The years from the age at peak height velocity were estimated for each participant, and used as the maturity index. A simple regression analysis was performed for the two variables in the full age range, as well as separately for the 5 − 12 years and 12 − 19 years subgroups.

Results and conclusion
The maturity index and chronological age were positively correlated with the relative muscle thickness, pennation angle, and fascicle length of MG. Subgroup analyses showed that chronological age was significantly correlated with the pennation angle, fascicle length, and absolute muscle thickness, except for the pennation angle of the 5 − 12 years subgroup. The present results indicate that muscle hypertrophy and elongation of fascicle length occur with growth. Our findings also suggest that the growth changes in pennation angle of MG differ between pre-adolescence and adolescence.
Hiding in plain sight: eating disorders in diverse populations - a case for comprehensive medical education
Authors: Brown Tashalee R. , Jansen Madeline O. , Hirsch Drew , Amir Habiba , Duncan Alexis E. , Nicol Ginger E. 
Published: December 2024

Abstract
Background
Training gaps regarding the diagnosis and management of eating disorders in diverse populations, including racial, ethnic, sexual, and gender minoritized groups, have not been thoroughly examined.

Objective
This study aimed to examine resident physicians’ knowledge and attitudes regarding eating disorders in diverse populations, with a focus on areas for improved training and intervention.

Methods
Ninety-two resident physicians in internal medicine, emergency medicine, obstetrics/gynecology, psychiatry, and surgery at an academic center completed an online survey from 12/1/2020–3/1/2021, which comprised multiple choice and vignette-style open-ended questions to assess knowledge and attitudes toward the management and clinical presentations of eating disorders. Overall, the survey response rate was 25.7%. Descriptive statistics were reported. Vignette-style questions were analyzed using inductive coding and the frequency of responses was reported.

Results
A minority of resident physicians self-reported confidence in their knowledge of the medical complications (n = 42, 45%), risk factors (n = 38, 41%), and clinical presentations (n = 32, 35%) associated with eating disorders. Responses to vignette-style questions correctly identified relevant management methods (such as electrolyte monitoring and referral to specialty care), but demonstrated limited knowledge of the clinical presentation of eating disorders. Furthermore, most respondents reported a lack of knowledge regarding eating disorders in sexual and gender minoritized patients (n = 68, 73.9%) as well as racial and ethnic minoritized patients (n = 64, 69.6%).

Conclusions
Our findings suggest concerning gaps in knowledge and confidence among resident physicians with regard to the diagnosis and treatment of eating disorders, particularly in racial, ethnic, sexual, and gender minoritized patients. Moreover, responses to vignette-like questions indicate significant homogeneity in respondents’ perceptions of the clinical presentation of eating disorders, reflecting cultural biases which associate eating disorders with underweight, young, female patients. The majority did not feel competent in treating eating disorders in diverse populations and expressed desire for additional training in this area. More research is needed to better understand and address these gaps in eating disorder training, with the goal of increasing equity in patient outcomes.
PCSK9 in T-cell function and the immune response
Authors: Wang Yuying , Fang Xiaosheng , Liu Jiarui , Lv Xiao , Lu Kang , Lu Yingxue , Jiang Yujie 
Published: December 2024

AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) was first reported in 2003 and confirmed to be strongly associated with familial hypercholesterolemia. Small-molecule inhibitors targeting PCSK9 provide an effective and safe method for managing hypercholesterolemia and reducing the cardiovascular risk. In recent years, increasing evidence has indicated other important roles for PCSK9 in inflammation, tumors, and even immune regulation. PCSK9 might be an attractive regulator of T-cell activation and expansion. It might mediate inflammation and regulate other types of immune cells. In this review, we summarize the current advances in the field of PCSK9 and provide a narrative of the biological processes associated with PCSK9. The relationships between PCSK9 and different T cells were investigated in depth. Finally, the signaling pathways associated with PCSK9 and the immune response are also summarized in this review.
Tracing the evolution of ancient Chinese military science through classical texts
Authors: Wu Mengcheng , Wang Dongbo 
Published: December 2024

Abstract
The diachronic evolution of ancient Chinese military science is replete with profound philosophy and rich practical experience. This paper aims to delve into the diachronic evolution of the content of ancient Chinese military texts from the perspective of information science, utilizing information technology to address the primary research problem of how ancient military thought and practices evolved over time. By collecting representative military texts from various historical periods in China and supplementing the data with translations via machine translation technology, a comprehensive corpus of ancient Chinese military texts has been constructed. Based on this corpus, various methods such as BERTopic topic modeling, automatic summarization, and named entity recognition have been employed to meticulously explore and analyze the themes, ideas, and technologies within these ancient military texts. The results indicate that the inheritance of the ideas from “The Art of War” by Sun Tzu is primarily concentrated in the Warring States period and the Song and Yuan dynasties. Moreover, the themes and technologies in ancient Chinese military texts exhibit a trend of gradual enrichment and diversification over the course of history.
Impact of implicit government guarantee on the credit spread of urban construction investment bonds
Authors: Chen Rongda , Li Han , Tang Xuhui , Jin Chenglu , Zhang Shuonan , Zhang Xinyu 
Published: December 2024

AbstractFinancing sources for urban construction have garnered significant attention globally. Among various financing methods, the urban construction investment bond (UCIB) is unique to China. The UCIB credit spread, which represents the compensation for credit risk, has become a focal point for researchers. However, owing to shortcomings of previous approaches, few scholars have accurately assessed the impact of implicit government guarantees on credit spreads. This study introduces an innovative approach that uses orthogonal decomposition to extract proprietary information from credit ratings, reflecting implicit government guarantees. After accounting for bond factors, local government financing vehicle factors, and macroeconomic conditions, the implicit government guarantee substantially reduces the UCIB's credit spread. This conclusion remains robust when controlling for investor attention, regional factors, or duration.
Comparative investigation of specific enzyme activities in the organs and tissues of the skin parasite Macrogyrodactylus congolensis (Monogenea: Gyrodactylidae)
Authors: Arafa Safaa Zaky , Abd El-Hady El-Sayed Kasem , El-Abbassy Samir Ahmed 
Published: December 2024

Abstract
Background
Macrogyrodactylus congolensis is a pathogenic skin parasite that infects the economically important fish Clarias gariepinus. Little is known about the physiology and histochemistry of M. congolensis. This study aims to investigate the localization of the enzymes alkaline phosphatase, acid phosphatase, adenosine triphosphatase, 5′-nucleotidase, and glucose-6-phosphatase activities within the main organs and tissues of M. congolensis.

Results
Using histochemical methods, the study revealed predominant positive enzyme reactivities throughout the body of M. congolensis, with each enzyme demonstrating distinct localization patterns across various organs and tissues. All five enzymes were detected in the intestine, testis, vesicula seminalis, and excretory canal. Nerve cells and cerebral region exhibited positive reactions for alkaline phosphatase, acid phosphatase, 5′-nucleotidase, and glucose-6-phosphatase. The subtegumental cells showed positive reactions only for alkaline phosphatase and acid phosphatase, implying a specialized function in the parasite’s protective mechanisms and host-parasite interaction. Compared to other gyrodactylids infecting the same host, M. congolensis exhibited more pronounced enzymatic activities.

Conclusion
The enzyme activities of alkaline phosphatase, acid phosphatase, adenosine triphosphatase, 5′-nucleotidase, and glucose-6-phosphatase were more prominent in most tissues and organs of M. congolensis. The localization and distribution patterns differed from those observed in other gyrodactylids infecting the same host, suggesting potential biological differences, such as variations in embryonic development. The study’s findings may help in developing treatments or management strategies in aquaculture, where skin parasites can significantly affect fish health and economic viability.
Population trends of the sugarcane leaf hopper Pyrilla perpusilla (Walker) (Homoptera: Lophopidae) and its parasitoids in relation to weather factors in the Tarai region of Uttarakhand, India
Authors: Tanveer Saba , Maurya R. P. 
Published: December 2024

Abstract
Background
Pyrilla perpusilla (Walker) is an important pest of sugarcane ecosystem in the Tarai region of Uttarakhand state of India. The study focused on investigating the population dynamics of Pyrilla (sugarcane leaf hopper) and its parasitoids under the natural field conditions.

Results
During the study, two important parasitoids, viz., Fulgoraecia Melanoleuca, a nymphal/adult parasitoid (Lepidoptera: Epipyropidae), and Cheiloneurus pyrillae, an egg parasitoid (Hymenoptera: Encyrtidae), were found associated with the sugarcane leaf hopper. The peak mean population of ecto-parasitoid, F. melanoleuca cocoon, was observed in November 2022–23 and 2023–24. The morning hour relative humidity showed a negative significant relation with the cocoon population. The maximum parasitization of nymphs and adults Pyrilla was found to be 46.7 and 46.0%, respectively, from September to October during 2022–23 and 2023–24 crop seasons, after that the declining trend in parasitization by F. melanoleuca was observed. An increasing trend was recorded in egg parasitization in July, when the maximum mean population density of Pyrilla egg batches (2.28 /leaf), nymphs (4.75/leaf) and adults (4.58/leaf) was found. Temperature and relative humidity had significant correlations with Pyrilla egg batches.

Conclusion
Overall, the study outlines the presence of Pyrilla and its naturally occurring parasitoids in the sugarcane ecosystem, along with the effects of weather conditions on Pyrilla’s population density and the parasitization rates of the parasitoids. The peak activity period of pest and its parasitoids was reported from September to November. Weather factors such as temperature ranging from 16 to 37.25 °C and relative humidity (62.7–93.8%) played a significant role in affecting their density and parasitization.
Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital
Authors: Ahmed Nashwa E. , Nagah Amina M. , Mohamed Omima R. , Mahmoud Ghada Mohamed , Elwia Sania K. 
Published: December 2024

Abstract

Background
Stroke is a major neurological disorder often exacerbated by substance abuse, including tramadol and cannabis. Understanding the molecular mechanisms underlying stroke pathogenesis in drug users can improve diagnosis and treatment. This study explores the roles of CYP4A11, CYP2E1, miR-27b, and miR-214-3p in the pathogenesis of stroke and their potential as diagnostic markers in individuals using tramadol and cannabis.

Results
Our findings indicate that CYP4A11 and CYP2E1 are significantly upregulated in the brain tissues of stroke patients who use tramadol and cannabis. Additionally, miR-27b and miR-214-3p levels were markedly altered, suggesting their involvement in stroke pathogenesis. The combined analysis of these biomarkers provided a robust diagnostic model with high sensitivity and specificity for identifying stroke in the context of drug addiction.

Conclusions
CYP4A11, CYP2E1, miR-27b, and miR-214-3p play critical roles in the pathogenesis of stroke in tramadol and cannabis users. These biomarkers hold promise as diagnostic tools, offering potential for early detection and personalized treatment strategies for stroke in drug-addicted populations. Further research is warranted to validate these findings and explore their therapeutic implications.
The use of human antiretroviral drugs (ARVs) in broiler chicken and domestic pig farming in Tanzania
Authors: Kimera Zuhura I. , Balandya Emmanuel C. , Matee Mecky I. N. , Adams Lisa V. 
Published: December 2024

Abstract
Background
The use of antiretroviral (ARV) drugs in Tanzania has led to a significant reduction in morbidity and mortality and improved quality of life among people living with HIV infection. However, the ease of access and availability of the drugs has, in some cases, led to misuse of the ARV in areas such as animal farming, posing a risk of the emergence of ARV resistance. The study’s objective was to investigate the use of ARV in animal farming and the factors associated with ARV use. We conducted a cross-sectional study in three regions (Dar es Salaam, Iringa, and Mbeya) using focus group discussions. The researchers used NVivo 12 software for qualitative data analysis.

Results
A total of 113 participants participated in this study. The participants mentioned the use of veterinary, human, and local medicines to be prevalent. The drivers for such usage are disease treatment and prevention, growth promotion, counterfeited drugs, higher cost of animal feeds, profit maximization, market competition, advice from veterinary drug sellers, and easy availability and accessibility of medicines. New Castle, respiratory diseases, and diarrhea were the most common diseases affecting broiler chickens, while limb paralysis, swine fever, and skin diseases were prominent in domestic pigs. The Dar es Salaam region has a scarcity of extension officers compared to the Mbeya and Iringa regions. Almost all FGD participants reported hearing about the use of ARVs and family planning injectable and pills. Some of the participants agreed to use these drugs for growth promotion since they are effective.

Conclusion
High usage of veterinary, human, and other medicines, including ARVs, in animal production predisposes the Tanzanian community to public health threats, including antibiotic and antiretroviral resistance. We recommend implementing urgent mitigation strategies to control the misuse of human ARVs in animal production.
Circ-PDE1C/miR-766-3p/SGTB axis regulates the IL-1β-induced apoptosis, inflammation and oxidative stress in human chondrocytes
Authors: Gao Lixia , He Tao , Hu Qingkui , Ma Yan 
Published: December 2024

Abstract
Background
Osteoarthritis (OA) is a common degenerative joint disease. Circular RNA Phosphodiesterase 1 C (circ-PDE1C, hsa_circ_0134111) has participated in the IL-1β-induced chondrocyte damages. The objective of our study was to explore the molecular mechanism of circ-PDE1C.

Methods
Circ-PDE1C, microRNA-766-3p (miR-766-3p) or Small Glutamine Rich Tetratricopeptide Repeat Co-Chaperone Beta (SGTB) expression was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cell counting kit-8 (CCK-8) assay and flow cytometry were used to analyze proliferation and apoptosis, respectively. Western blotting assay was performed for protein detection. The inflammatory cytokines were measured by Enzyme-linked immunosorbent assay (ELISA). Oxidative stress was assessed by commercial kits. Target analysis was conducted by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay.

Results
Circ-PDE1C was abnormally overexpressed in OA tissues and IL-1β-exposed chondrocytes. Downregulation of circ-PDE1C alleviated the IL-1β-induced cell apoptosis, inflammation, extracellular matrix degradation and oxidative stress. Circ-PDE1C could interact with miR-766-3p to serve as miRNA sponge. The function of si-circ-PDE1C was attributed to the inhibition of miR-766-3p. Additionally, miR-766-3p directly targeted the 3’UTR of SGTB. The miR-766-3p upregulation impeded the IL-1β-triggered cell damages through reducing the level of SGTB. Moreover, SGTB expression was regulated by circ-PDE1C via binding to miR-766-3p in IL-1β-induced chondrocytes.

Conclusion
Altogether, circ-PDE1C enhanced the IL-1β-induced dysfunction in chondrocytes via upregulating SGTB by targeting miR-766-3p.
A novel approach for detecting malicious hosts based on RE-GCN in intranet
Authors: Xu Haochen , Geng Xiaoyu , Liu Junrong , Lu Zhigang , Jiang Bo , Liu Yuling 
Published: December 2024

AbstractInternal network attacks pose a serious security threat to enterprises and organizations, potentially leading to critical information leaks and network system damage. Hosts, as the core data and service bearers, are often primary targets of cyber attacks. Therefore, accurately identifying hosts with malicious behavior in the network is crucial. However, detecting malicious hosts on this intranet presents several challenges. Firstly, the network state is unstructured data that dynamically changes in real-time. Secondly, the large amount of normal traffic in the network drowns out the traces generated by malicious behaviors, leading to the problem of category imbalance. Lastly, the traditional graph neural network model has limitations in processing edge information and is unable to directly learn the information in netflow. To overcome these challenges, this paper proposes a malicious host detection system. The system extracts the Host Communication Graph by time slicing and uses a random undersampling method to balance samples. For malicious host detection, this paper proposes the Relational-Edge Graph Convolutional Network (RE-GCN) model, which can directly aggregate and learn features on edges and use them to accurately classify nodes, compared to other GNN models. Comparative experiments were conducted on various netflow datasets, demonstrating the effectiveness of our approach. Our approach outperformed other common GNN models in detecting malicious hosts.
In vivo kinematic analysis of failure cases after nonanatomical anterior cruciate ligament reconstruction: a preliminary study
Authors: Kage Tomofumi , Taketomi Shuji , Tomita Tetsuya , Yamazaki Takaharu , Yamagami Ryota , Kono Kenichi , Kawaguchi Kohei , Murakami Ryo , Arakawa Takahiro , Kobayashi Takashi , Inui Hiroshi , Tanaka Sakae 
Published: December 2024

Abstract
Background
Nonanatomical anterior cruciate ligament (ACL) reconstruction occasionally induces ACL failure without an evident injury episode, necessitating revision surgery. Although the in vivo kinematics of ACL deficiency before primary ACL reconstruction are well documented, the kinematics of ACL failure after nonanatomical reconstruction remain unexplored. The aim of this study is to investigate ACL failure kinematics following nonanatomical reconstruction.

Patients and methods
This study enrolled three patients with ACL failure after nonanatomical reconstruction, 20 normal and 16 ACL-deficient knees. The anteroposterior (AP) translation of the medial and lateral femoral condyles and center of the femur and femoral rotation relative to the tibia during squatting were evaluated using a two- to three-dimensional registration technique under fluoroscopy.

Results
Medial AP translation of the nonanatomically reconstructed knee in one patient showed posterior location and abnormal kinematics compared with the ACL-deficient knees. In contrast, the lateral AP position of the nonanatomically reconstructed knees in two patients were more posteriorly located and showed more abnormal kinematics than the ACL-deficient knees. Central AP translation of the nonanatomically reconstructed knees in two patients was located more posteriorly throughout the range of midflexion. Femoral rotation of the nonanatomically reconstructed knees showed abnormal kinematics compared with that of the normal and ACL-deficient knees.

Conclusions
By independently assessing the medial and lateral aspects of the femur, the medial or lateral condyle of the femur of nonanatomically reconstructed knees exhibited a more pronounced abnormality compared with ACL-deficient knees. The femur of the nonanatomically reconstructed knees showed abnormal rotational kinematics. Considering the kinematic aspect, nonanatomical ACL reconstruction should be avoided.