bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe and Effective Digital Anticoagulation: A Continuous Iterative Improvement Approach
Authors: Austin Jodie A. , Barras Michael A. , Sullivan Clair M. 
Published: November 2021

Abstract
Background Anticoagulant drugs are the leading cause of medication harm in hospitals and prescribing errors are common with traditional paper prescriptions. Electronic medicines management can reduce prescribing errors for many drugs; however, little is known about the impact of e-prescribing on anticoagulants. Our case study reports on the lessons learned during conversion from paper to e-prescribing and the ongoing optimization process.
Methods The iterative implementation of an anticoagulant prescribing platform in an integrated electronic medical record (ieMR) and ongoing continuous enhancements was applied across five digital hospital sites utilizing a single domain. The collaborative management of each class of anticoagulant, optimization strategies, governance structures, and lessons learned is described. An analysis of the rate of errors and adverse events pre- and post-go live is presented.
Results The transition to e-prescribing relied on a strong inter-disciplinary governance framework to promote the safe management of anticoagulants. There was no increase in overall prescribing errors, however unfamiliarity with the new system caused a transient increase in errors with unfractionated heparin (1.8/month pre-ieMR vs. 5.5/month post-ieMR). A dedicated real-time surveillance dashboard was introduced. The iterative nature of changes indicated the complexities involved with anticoagulants and the need for an interactive, optimization approach. This led to a significant decrease in anticoagulant related hospital acquired complications (12.1/month pre-ieMR vs. 7.8/month post-ieMR, p = 0.01).
Conclusion Digitizing anticoagulant prescribing led to an overall reduction in errors, but a continuous iterative optimization approach was needed to achieve this outcome. The knowledge presented can help inform optimal therapeutic anticoagulation ieMR design strategies.
Patient Characteristics Associated with Seizure Freedom after Vagus Nerve Stimulation in Pediatric Intractable Epilepsy: An Analysis of “Super-Responders”
Authors: Tamura Goichiro , Lo William B. , Yau Ivanna , Vaughan Kerry A. , Go Cristina , Singleton William G.B. , Hazon David , Yan Han , Otsubo Hiroshi , Donner Elizabeth J. , Rutka James T. , Ibrahim George M. 
Published: November 2021

AbstractClinical responses to vagus nerve stimulation (VNS) therapy for intractable epilepsy can be unpredictable, and factors that predict response to therapy are elusive. Minority of children undergoing VNS achieve seizure freedom. The current study aimed to characterize this exceptional patient population, defined as “super-responders” (SRs). Retrospective data were collected from 150 children who underwent VNS at a single pediatric institution. The patients' mean age at VNS device implantation was 12.0 years (range, 3.09–17.9 years). Ten SRs (6.7%) were identified who achieved and maintained seizure freedom for longer than 1 year following implantation. The interval between epilepsy onset and VNS device implantation was significantly shorter in SRs than in the other children (mean epilepsy duration 5.72 vs. 8.44 years, respectively; p = 0.032). SRs also had a significantly shorter proportion of life with epilepsy compared with the other children (mean ratio of epilepsy duration to age at implantation 0.52 vs. 0.71, respectively; p = 0.023). SRs reported their seizure freedom relatively early (six patients within 6 months and all patients within 12 months after implantation) at relatively low device settings (mean output current 0.81 mA at their last follow-up). Compared with conventional models, responsive VNS models with autostimulation features did not increase the ratio of SRs. No other clinical or imaging characteristic difference between SRs and the other children was found in this cohort. The current study showed a significant association between shorter epilepsy duration and shorter proportion of life with epilepsy and seizure freedom after VNS.
Perinatal Outcomes among Women Identified by a Community Health Needs Assessment
Authors: Duryea Elaine L. , Martin Robert , McIntire Donald , Spong Catherine Y. , Nelson David B. 
Published: November 2021

Objective The aim of the study is to compare perinatal outcomes for women with greater social needs, as identified by the Community Health Needs Assessment, to those of women living in other areas of the county.
Study Design This was a retrospective cohort study of pregnant women delivering at a large inner-city county hospital. Perinatal outcomes were analyzed for women living within a target area with substantial health disparities and social needs, and compared with those women living outside the target area. Statistical analysis included student's t-test, Chi square, and logistic regression.
Results Between January 2015 and July 2020, 66,936 women delivered at Parkland hospital. Of these, 7,585 (11%) resided within the target area. These women were younger (26.8 ± 6.5 vs. 27.9 ± 6.4 years, p < 0.001), more likely to be black (37 vs. 13%, p < 0.001), and had a higher body mass index or BMI (33.3 ± 7.0 vs. 32.6 ± 6.4 kg/m2, p < 0.001). All women were likely to access prenatal care, with 7,320 (96.5%) in the target area and 57,677 (97.2%) outside the area attending at least one visit. Adverse perinatal outcomes were increased for women living within the target area, which persisted after adjustment for age, race, and BMI. This included an increased risk of preeclampsia (adjusted risk ratio [aRR] 1.1, 95% confidence interval or CI [1.03, 1.2]) and abruption (aRR 1.3, 95% CI [1.1, 1.7]), as well as preterm birth before both 34 weeks (aRR 1.3, 95% CI [1.2, 1.5]) and 28 weeks (aRR 1.3, 95% CI [1.02,1.7]). It follows that neonatal ICU admission (aRR 2.1, 95% CI [1.3, 3.4]) and neonatal death (aRR 1.2, 95% CI [1.1, 1.3]) were increased within the target area. Interestingly, rate of postpartum visit attendance was higher in the target area (57 vs. 48%), p < 0.001.
Conclusion Even among vulnerable populations, women in areas with worse health disparities and social needs are at greater risk of adverse perinatal outcomes. Efforts to achieve health equity will need to address social disparities.
Key Points
Uniform deposition method of monodispersed SiO2 nanoparticles on a 300-mm Si wafer surface
Authors: Lee Seungjae , Choi Seulgi , Cho Yujin , Oh Haerim , Chae Seung-Ki , Kim Taesung 
Published: November 2021

A study of the uniform deposition of nanoparticles across a 300-mm wafer was conducted to assess the uniformity of the wafer center-to-edge cleaning technique. A new method of particle deposition was devised different from the conventional method using electrostatic force. The strategy implements wafer rotation and deposition through principles of convection and diffusion. In this study, we focused on the effect of wafer rotation speed on particle deposition. After determining optimum conditions, fine results were obtained with a well-deposited shape and an excellent particle size uniformity of above 70% over the entire area of the wafer except in unusual cases. Deposition results were confirmed with KLA-Tencor Surfscan SP5 commonly used by foundries, and logic and memory manufacturers around the world to increase node development and production. The inherent index of the refraction value by Surfscan SP5 caused a particle size shift in measurement results. However, scanning electron microscopy and scanning mobility particle sizer analysis results revealed that 80-, 60-, 40-, 30-, and 20-nm-sized silica nanoparticles were well deposited on the wafer. Through this research, we believe that standard wafers processed with this particle deposition method will be useful for performance evaluation of wafer cleaning technology and calibration of wafer inspection technology during development.
Optimization of shaped pulses for radio frequency excitation in NMR logging
Authors: Shi Guanghui , Xiao Lizhi , Luo Sihui , Long Zhihao , Wang Zhengduo 
Published: November 2021

The radio frequency (RF) excitation pulse of the nuclear magnetic resonance (NMR) logging tool can realize slice measurement by designing shaped pulses. In the case of a certain main magnetic field, the accuracy of the shaped pulse design has a very important impact on the signal-to-noise ratio (SNR) of the NMR signal and the measurement of the short relaxation signal. Hard pulse excitation will produce an undesirable infinite number of side lobes that may perturb the spins in unwanted regions. Soft pulse can achieve selective excitation and has a better slice profile and shorter energy release time while it is not conducive to the measurement of short relaxation signals. This article focuses on the design of shaped pulses in extreme downhole environments and analyzes the characteristics of the three shaped pulses in the two cases of equivalent bandwidth and equivalent pulse duration. At the same time, a kind of RF-shaped pulse transmitting circuit with phase difference control is realized. According to the pulse type optimization strategy, the appropriate shaped pulse is selected. When echo spacing (TE) &gt;0.6 ms, the SNR can be increased to more than 12%. When TE is small, it will automatically switch to the hard pulse mode, which is good for short relaxation measurement.
Cover crop residue diversity enhances microbial activity and biomass with additive effects on microbial structure
Authors: Shu Xin , Zou Yiran , Shaw Liz J. , Todman Lindsay , Tibbett Mark , Sizmur Tom 
Published: November 2021

Context Cover crops are used to improve soil fertility and environmental sustainability. Decomposition of cover crop residues can affect belowground microbial communities and activity, which is important for soil functions (e.g. nutrient cycling, organic matter decomposition). Aims We investiagated the effect of plant residues from a range of cover crop species on soil microbial activity, diversity and microbial community composition. Methods A mixture of four cover crop residues (buckwheat, clover, sunflower, radish) or an equal mass of the residues of each of the individual species were assessed for their effect on soil respiration and soil microbial community structure. Key results Cover crop residue incorporation significantly (P < 0.001) increased soil respiration during 84 days incubation and this response caused a significant change in microbial community composition by increasing the proportion of fungi and Gram-positive bacteria at the cost of decreasing Gram-negative bacteria. The mixture of cover crop residues had a significantly (P < 0.05) greater soil respiration rate, by 57.61 μg C g−1 h−1, than the average of the four individual residues, but did not have a significantly different soil microbial biomass or microbial community structure. Conclusions Greater diversity of organic resources increased the number biochemical niches, and activated dormant microbial communities to increase activity without affecting biomass or community composition. Greater respiration from similar microbial biomasses suggests that microbial activity might be more efficient following more diverse substrate input. Implications The positive impact of cover crop residues on soil microbial activity suggests that mixtures of cover crop residues may enhance soil functions beyond the sum of individual cover crop residues.
-ŋ plurals in North Lombard varieties
Authors: Manzini Maria Rita , Savoia Leonardo M. , Baldi Benedetta 
Published: November 2021

Abstract
We focus on North Lombard -a and -n feminine plurals, for which we provide a morphological analysis. At the syntactic level, the relevant varieties are characterized by the phenomenon of Differential Plural Marking, whereby phasal domains have different realizations of plural morphology on the head of the phase and on the complement of the phase. We provide an account of DPM based on the assumption that under the PIC the complement of the phase and its head are externalized separately. We draw consequences concerning clitics as phasal heads as well as object agreement with participles and with finite verbs.
Aspect in the acquisition of the Spanish locative paradigm by Italian L2 learners
Authors: Perpiñán Silvia , Marín Rafael 
Published: November 2021

Abstract
The present study investigates the development of the expression of the locative paradigm in the L2 Spanish of Italian-speaking learners. We investigate (i) whether the developmental stages proposed for English-speaking learners (VanPatten 1987; Perpiñán, Marín & Moreno Villamar 2020) hold for Italian-speaking learners; and (ii) whether Italian, a language that partially overlaps with the distribution of the Spanish copulas has a facilitative role in the process. 33 Italian-speaking learners of Spanish and 21 monolingual Spanish speakers completed a short proficiency test, an acceptability judgement task, and a picture matching task targeting these constructions. Results indicate that unlike what VanPatten (1987, 2010) has proposed for English-speaking learners of Spanish, Italian speakers do not present a delay in the acquisition of estar, but instead, it is overproduced in locative contexts from very early on. We argue that this overproduction of estar is due to the readily available mapping of ‘temporal boundedness’ with estar in the grammar of these L2 learners, whereas the presence of the feature ‘dynamicity’, even though it is relevant in the distribution of copulas in Italian, comes later in L2 development.
Catalan nativization patterns in the light of weighted scalar constraints
Authors: Pons-Moll Claudia , Torres-Tamarit Francesc 
Published: November 2021

Abstract
In this paper we analyze, from an experimental and formal perspective, the interaction and the implicational relationships between vowel reduction and word-final nasal deletion in Catalan loanwords. We present the results of both a production and a perception test carried out with 31 young speakers from the Barcelona area. Loanwords susceptible to undergoing both nasal deletion and vowel reduction display different patterns, which, according to the tests, show different degrees of likeliness. The most common pattern is underapplication of both processes, followed closely by underapplication of nasal deletion alone and at a large distance by the application of both processes. Finally, underapplication of vowel reduction and application of nasal deletion is unattested in the production test and obtains a very low score in the perception test, that is, it is a very unlikely nativization pattern. The typology of possible nativizations and the implicational relationships between the processes under scrutiny are analyzed in the framework of Harmonic Grammar under Weighted Scalar Constraints, following recent proposals by Hsu & Jesney (2017, 2018).
Effect of annealing temperature and time on recrystallization behavior of Mg-Gd-Y-Zn-Zr alloy
Authors: Han Rui , Jia Leichen , Zhang Zhimin , Wang Qiang , Yu Jianmin , Xu Jian , Xue Yong 
Published: November 2021

Abstract
In this paper, the effect of annealing treatment on the microstructure and hardness of extruded Mg-9Gd-4Y-2Zn-0.5Zr alloy (wt. %) was discussed. The microstructure evolution of the alloy under different annealing conditions was studied by optical microscope (OM), scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD), and the variation of hardness was analyzed. With the increase of annealing temperature, the large deformed grains first break into small recrystallized grains. When the temperature continues to increase, the recrystallized grains grow abnormally with the precipitation of chain phase and the fragmentation of lamellar long-period stacking ordered (LPSO) phase. The alloy does not recrystallize at low temperature, and the recrystallize grains grow abnormally at high temperature. The increase of annealing time will also lead to abnormal growth of recrystallized grains. The texture gradually diffuses from the classical extrusion texture to the extrusion direction (ED). The results show that under the condition of 430 °C × 5 h, the recrystallization volume of the alloy is the largest, the recrystallization grain distribution is uniform, and the hardness value is the highest.
3D-bioprinted microenvironments for sweat gland regeneration
Authors: Song Wei , Yao Bin , Zhu Dongzhen , Zhang Yijie , Li Zhao , Huang Sha , Fu Xiaobing 
Published: November 2021

AbstractThe development of 3D bioprinting in recent years has provided new insights into the creation of in vitro microenvironments for promoting stem cell-based regeneration. Sweat glands (SGs) are mainly responsible for thermoregulation and are a highly differentiated organ with limited regenerative ability. Recent studies have focused on stem cell-based therapies as strategies for repairing SGs after deep dermal injury. In this review, we highlight the recent trend in 3D bioprinted native-like microenvironments and emphasize recent advances in functional SG regeneration using this technology. Furthermore, we discuss five possible regulatory mechanisms in terms of biochemical factors and structural and mechanical cues from 3D bioprinted microenvironments, as well as the most promising regulation from neighbor cells and the vascular microenvironment.
Left ventricular shape predicts arrhythmic risk in fibrotic dilated cardiomyopathy
Authors: Balaban Gabriel , Halliday Brian P , Hammersley Daniel , Rinaldi Christopher A , Prasad Sanjay K , Bishop Martin J , Lamata Pablo 
Published: November 2021

Abstract

Aims
Remodelling of the left ventricular (LV) shape is one of the hallmarks of non-ischaemic dilated cardiomyopathy (DCM) and may contribute to ventricular arrhythmias and sudden cardiac death. We sought to investigate a novel three dimensional (3D) shape analysis approach to quantify LV remodelling for arrhythmia prediction in DCM.

Methods and results
We created 3D LV shape models from end-diastolic cardiac magnetic resonance images of 156 patients with DCM and late gadolinium enhancement (LGE). Using the shape models, principle component analysis, and Cox-Lasso regression, we derived a prognostic LV arrhythmic shape (LVAS) score which identified patients who reached a composite arrhythmic endpoint of sudden cardiac death, aborted sudden cardiac death, and sustained ventricular tachycardia. We also extracted geometrical metrics to look for potential prognostic markers. During a follow-up period of up to 16 years (median 7.7, interquartile range: 3.9), 25 patients met the arrhythmic endpoint. The optimally prognostic LV shape for predicting the time-to arrhythmic event was a paraboloidal longitudinal profile, with a relatively wide base. The corresponding LVAS was associated with arrhythmic events in univariate Cox regression (hazard ratio = 2.0 per quartile; 95% confidence interval: 1.3–2.9), in univariate Cox regression with propensity score adjustment, and in three multivariate models; with LV ejection fraction, New York Heart Association Class III/IV (Model 1), implantable cardioverter-defibrillator receipt (Model 2), and cardiac resynchronization therapy (Model 3).

Conclusion
Biomarkers of LV shape remodelling in DCM can help to identify the patients at greatest risk of lethal ventricular arrhythmias.
Effectiveness of non-opioid interventions to reduce opioid withdrawal symptoms in patients with chronic pain: a systematic review
Authors: Langejan Annely I , de Kleijn Loes , Rijkels-Otters Hanneke J B M , Chudy Stan F J , Chiarotto Alessandro , Koes Bart W 
Published: November 2021

AbstractBackgroundDealing with the opioid crisis, medical doctors are keen to learn how to best treat opioid dependency in patients with chronic non-cancer pain. Opioid replacement therapy is commonly used, but success rates vary widely. Since many patients still experience severe withdrawal symptoms, additional interventions are necessary.ObjectiveTo review the effectiveness of interventions in the treatment of withdrawal symptoms during opioid tapering or acute withdrawal in patients with long-term non-cancer pain.MethodsA systematic review was conducted in Embase.com, MEDLINE, Web of Science, PsycINFO, and Cochrane CENTRAL register of trials. Studies eligible for inclusion were (non-)randomized controlled trials in adults with long-term opioid prescriptions for non-cancer pain. Included trials had to compare a non-opioid intervention to placebo, usual care, no treatment, or non-opioid drug and had to report on withdrawal symptoms as an outcome. Study quality was assessed with the 2.0 Cochrane risk of bias (RoB) tool. Evidence quality was rated following the GRADE approach.ResultsOne trial (n = 21, some concerns regarding RoB) compared Varenicline to placebo. There was no statistically significant between-group reduction of withdrawal symptoms (moderate-quality evidence).ConclusionsEvidence from clinical trials on interventions reducing withdrawal symptoms is scarce. Based on one trial with a small sample size, no firm conclusion can be drawn. Meanwhile, doctors are in dire need for therapeutic options to tackle withdrawal symptoms while tapering patients with prescription opioid dependence. We hope this review draws attention to this unfortunate research gap so that future research can provide doctors with answers.
Narratives Beyond books: Artistic Agency and Encounter with an Audience in the Work of the Compagnia delle poete and Gabriella Ghermandi
Authors: Panzarella Gioia 
Published: November 2021

Abstract
Building on recent critical contributions on contemporary transnational literature in the Italian language, this article explores the link between the literary production of the artist Gabriella Ghermandi and the Compagnia delle poete – a collective of 20 female artists from different countries – and some of their respective performances. I argue that these performances reduce the space for interventions by the cultural intermediaries involved in the organization of events aimed at disseminating the Compagnia’s and Ghermandi’s literary production: the performances constitute new interzonal artistic explorations and preserve the agency of the artists when presenting their narrative around their own literary production; they emphasize the element of collaboration and can be discussed as part of a process of self-translation. This article pays particular attention to the prominence of the theme of migration in public discourse in Italy, which has provided opportunities for writers and artists with an interest in migration to take part in cultural events.