bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic syndrome, fatty liver, and artificial intelligence-based epicardial adipose tissue measures predict long-term risk of cardiac events: a prospective study
Authors: Lin Andrew , Wong Nathan D. , Razipour Aryabod , McElhinney Priscilla A. , Commandeur Frederic , Cadet Sebastien J. , Gransar Heidi , Chen Xi , Cantu Stephanie , Miller Robert J. H. , Nerlekar Nitesh , Wong Dennis T. L. , Slomka Piotr J. , Rozanski Alan , Tamarappoo Balaji K. , Berman Daniel S. , Dey Damini 
Published: January 2021

Abstract
Background
We sought to evaluate the association of metabolic syndrome (MetS) and computed tomography (CT)-derived cardiometabolic biomarkers (non-alcoholic fatty liver disease [NAFLD] and epicardial adipose tissue [EAT] measures) with long-term risk of major adverse cardiovascular events (MACE) in asymptomatic individuals.

Methods
This was a post-hoc analysis of the prospective EISNER (Early-Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study of participants who underwent baseline coronary artery calcium (CAC) scoring CT and 14-year follow-up for MACE (myocardial infarction, late revascularization, or cardiac death). EAT volume (cm3) and attenuation (Hounsfield units [HU]) were quantified from CT using fully automated deep learning software (< 30 s per case). NAFLD was defined as liver-to-spleen attenuation ratio < 1.0 and/or average liver attenuation < 40 HU.

Results
In the final population of 2068 participants (59% males, 56 ± 9 years), those with MetS (n = 280;13.5%) had a greater prevalence of NAFLD (26.0% vs. 9.9%), higher EAT volume (114.1 cm3 vs. 73.7 cm3), and lower EAT attenuation (−76.9 HU vs. −73.4 HU; all p < 0.001) compared to those without MetS. At 14 ± 3 years, MACE occurred in 223 (10.8%) participants. In multivariable Cox regression, MetS was associated with increased risk of MACE (HR 1.58 [95% CI 1.10–2.27], p = 0.01) independently of CAC score; however, not after adjustment for EAT measures (p = 0.27). In a separate Cox analysis, NAFLD predicted MACE (HR 1.78 [95% CI 1.21–2.61], p = 0.003) independently of MetS, CAC score, and EAT measures. Addition of EAT volume to current risk assessment tools resulted in significant net reclassification improvement for MACE (22% over ASCVD risk score; 17% over ASCVD risk score plus CAC score).

Conclusions
MetS, NAFLD, and artificial intelligence-based EAT measures predict long-term MACE risk in asymptomatic individuals. Imaging biomarkers of cardiometabolic disease have the potential for integration into routine reporting of CAC scoring CT to enhance cardiovascular risk stratification.
Trial registration NCT00927693.
Virtual barriers: unpacking the sustainability implications of online food spaces and the Yellowknife Farmers Market’s response to COVID-19
Authors: Radcliffe Josalyn , Skinner Kelly , Spring Andrew , Picard Lise , Benoit France , Dodd Warren 
Published: January 2021

Abstract
Background
Through their support of local agriculture, relationships, and healthy diets, farmers markets can contribute to a sustainable food system. Markets like the Yellowknife Farmers Market (YKFM) are social spaces that support local food, yet the COVID-19 pandemic has forced changes to their current model. We explore the potential of online marketplaces to contribute to a resilient, sustainable food system through a case study of the YKFM.

Methods
In 2019, a collaborative mixed-method evaluation was initiated by the YKFM and university partners in the Northwest Territories (NWT), Canada. The evaluation included an in-person Rapid Market Assessment dot survey and questionnaire of market patrons from two YKFM dates prior to the pandemic. Due to COVID-19, a vendor survey and interviews were deferred. Data collected from the two patron surveys, alongside researcher observations, available literature, public announcements, and informal email and phone discussions, inform the discussion.

Results
For the patron surveys, 59 dot survey and 31 questionnaire participants were recruited. The top motivators for attendance were eating dinner, atmosphere, and supporting local businesses, and most patrons attended as couples and spent over half of their time talking to others. The YKFM did not move online; instead, they proposed and implemented a “Shop, don’t stop” market. Informal conversations suggested the small scale of the market and technology challenges were perceived barriers to moving online. The physically-distanced market was well-attended and featured in local media.

Conclusions
NWT food strategies rely on farmers markets to nurture a local food system. Data suggest a potential incongruence between an online model and important market characteristics such as the event-like atmosphere. Available literature suggests online markets can support local food by facilitating purchasing and knowledge-sharing, yet they do not replicate the open-air or social experience. The decision not to move online for the YKFM reflects market patron characteristics and current food context in Yellowknife and the NWT. While online adaptation does not fit into the YKFM plan today, online markets may prove useful as a complementary strategy for future emerging stressors to enhance the resiliency of local systems.
Evaluation of right myocardial performance index of in vitro fertilization fetuses and spontaneous pregnancy fetuses: a cross-sectional study
Authors: Chen Shaoqi , Zhuang Zemin , Chen Qingzi , Du Xiya , Li Weiping , Tan Xuerui 
Published: January 2021

Abstract
Background
Whether the in vitro fertilization (IVF) has an effect on the cardiac function of the fetus is very important to evaluate the safety of the technique. The aim of this paper is to establish normal reference range for the fetal right myocardial performance index (RMPI), and compare the reference range between IVF fetuses and spontaneous pregnancy (SP) fetuses by automatic measurement of the RMPI.

Methods
Three hundred seventy-one spontaneous singleton pregnancies (the control group) and 39 singleton pregnancies conceived by IVF (the experimental group) were enrolled into the current study. An automatic measurement system was used to acquire the RMPI. The cardiac function of the two groups was compared by t-test.

Results
There was no significant difference in normal reference range of RMPI between IVF fetuses and SP fetuses (RMPI 0.42 ± 0.05 vs 0.43 ± 0.05). No strong correlation was also noted between RMPI with gestational age and heart rate.

Conclusions
Normal reference ranges of RMPI of IVF fetuses and SP fetuses were established, and no significant difference between IVF fetuses and SP fetuses in RMPI was found. Thus, these findings may suggest that IVF has little impact on cardiac function of the fetus.
My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype
Authors: Zhou Yadi , Zhao Junfei , Fang Jiansong , Martin William , Li Lang , Nussinov Ruth , Chan Timothy A. , Eng Charis , Cheng Feixiong 
Published: January 2021

AbstractMassive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols. MPM contains 490,245 mutations from over 10,800 tumor exomes across 33 cancer types in The Cancer Genome Atlas mapped to 94,563 structure-resolved/predicted protein-protein interaction interfaces (“edgetic”) and 311,022 functional sites (“nodetic”), including ligand-protein binding sites and 8 types of protein posttranslational modifications. In total, 8884 survival results and 1,271,132 drug responses are obtained for these mapped interactions. MPM is available athttps://mutanome.lerner.ccf.org.
Activation of ChTLR15/ChNF-κB-ChNLRP3/ChIL-1β signaling transduction pathway mediated inflammatory responses to E. tenella infection
Authors: Li Jian , Yang Xuelian , Jia Zhipeng , Ma Chunli , Pan Xinghui , Ma Dexing 
Published: January 2021

AbstractAvian coccidiosis caused by Eimeria leads to severe economic losses in the global poultry industry. Although chicken Toll-like receptor 15 (ChTLR15) was reported to be involved in Eimeria infection, the detailed mechanism underlying its role in the inflammatory response remains to be discovered. The present study demonstrated that the mRNA expression levels of ChTLR15, ChMyD88, ChNF-κB, ChNLRP3, ChCaspase-1, ChIL-18 and ChIL-1β and the protein levels of ChTLR15 and ChNLRP3 in cecal tissues of Eimeria-infected chickens were significantly elevated at 4, 12, and 24 h compared with those in noninfected control chickens (p < 0.01). Moreover, the mRNA levels of molecules in the ChTLR15/ChNF-κB and ChNLRP3/ChIL-1β pathways and the protein levels of ChTLR15 and ChNLRP3 in chicken embryo fibroblast cells (DF-1) stimulated by E. tenella sporozoites were consistent with those in Eimeria-infected chickens. Furthermore, overexpression of ChTLR15 in DF1 cells augmented activation of the ChTLR15/ChNF-κB and ChNLRP3/ChIL-1β pathways when stimulated with E. tenella sporozoites, while knockdown of ChTLR15 in DF1 cells showed inverse effects. Taken together, the present study provides evidence that E. tenella sporozoites specifically activate ChTLR15 and then trigger activation of the ChNLRP3/ChIL-1β pathway, which partially mediates inflammatory responses to Eimeria infection.
Chronic abdominal aortic dissection, endovascular treatment using a new Stent-graft for in situ Fenestration
Authors: Bertoni Hernan G. , Girela German A. , Barone Hector D. , De Caso Federico , De La Vega Alejandro , Bui Bao T. , Maldonado Thomas 
Published: January 2021

Abstract
Background
Although endovascular treatment of the thoracic aorta (TEVAR) has become an elective procedure for treatment of complicated type B aortic dissection, its role in treating post dissection thoraco-abdominal aortic aneurysm (TAAA), is still limited. This is a case of aortic vascular disease, which reports the use of a new endovascular device.

Case presentation
: We present the case of a 62 year old male patient with a history of hypertension, active smoker, who presented penetrating descending thoracic aortic ulcer in the setting of a chronic abdominal aortic dissection. The patient was treated using a new stent graft capable of in situ fenestration that allowed crossing the stent-graft membrane, implanting a covered stent to exclude the re-entry at the level of the left renal artery and redirecting the blood flow through the true lumen.

Conclusions
This case report demonstrates the feasibility of a novel stent-graft concept. Larger studies with longer follow-up are essential to fully evaluate the safety and effectiveness of this new design.
Fabrication of 3D-printed hygromorphs based on different cellulosic fillers
Authors: Langhansl Matthias , Dörrstein Jörg , Hornberger Peter , Zollfrank Cordt 
Published: January 2021

AbstractThe aim of this work is to characterize the moisture-dependent actuation behavior of bioinspired and additively manufactured hygromorphs based by following deductive and inductive design approaches. Fused Filament Fabrication (FFF) is employed to print bilayered structures consisting of swellable active layers and rigid passive layers. The active layer is composed of a polylactic acid (PLA) matrix filled with different hygroscopic cellulosic materials (native and modified) up to a filler content of 50 m%. Acrylonitrile Butadiene Styrene (ABS) is used for the passive layer. The FFF process allows the generation of desired differential swelling properties in the composites upon moisture absorption. The moisture dependent actuation strain of the printed bilayers was determined by video analyses. Some influencing geometrical factors which contribute to the actuation were deduced from x-ray diffraction (XRD) and micro computed tomography (μCT). The investigation of the mean cellulose microfibril orientation on the surface of the active layer suggested a preferential orientation with respect to printing direction. Furthermore, a gradient of cellulosic material within a single printed layer was observed, which indicates fiber sedimentation. Comparison with the thermomechanical model derived from Timoshenko (1925) shows that the computational prediction of the moisture dependent actuation is considerably accurate for most selected cellulosic materials and filler contents.
Deep inspiration breath hold versus free breathing technique in mediastinal radiotherapy for lymphoma
Authors: Houlihan Orla Anne , Rangaswamy Guhan , Dunne Mary , Rohan Christine , O'Neill Louise , Chalke Shelton , Daly Patricia , Gillham Charles , McArdle Orla 
Published: January 2021

Objective: Radiotherapy plays an important role in the management of lymphoma and many patients with lymphoma are cured with treatment. Risk of secondary malignancy and long-term cardiac and pulmonary toxicity from mediastinal radiotherapy exists. Delivery of radiotherapy using a deep inspiration breath-hold (DIBH) technique increases lung volume and has the potential to reduce dose to heart and lungs. We undertook a prospective study to assess the dosimetric differences in DIBH and free breathing (FB) plans in patients requiring mediastinal radiotherapy in clinical practice. Methods: We performed both FB and DIBH planning scans on 35 consecutive patients with mediastinal lymphoma needing radiotherapy. Contours and plans were generated for both data sets and dosimetric data were compared. All patients were planned using volumetric modulated arc therapy (VMAT). Data were compared for FB and DIBH plans with each patient acting as their own control using the related-samples Wilcoxon signed rank test. Results: DIBH significantly reduced lung doses (mean 10.6 vs 11.4Gy, p < 0.0005; V20 16.8 vs 18.3%, p = 0.001) and spinal cord maximum dose (20.6 vs 22.8Gy, p = 0.001). DIBH increased breast V4 (38.5% vs 31.8%, p = 0.006) and mean right breast dose (4.2 vs 3.6Gy, p = 0.010). There was no significant difference in heart doses when the entire study cohort was considered, however, mean heart dose tended to be lower with DIBH for upper mediastinal (UM) tumours (4.3 vs 4.9Gy, p = 0.05). Conclusion: Our study describes the potential benefit of DIBH in a population reflective of clinical practice. DIBH can decrease radiation dose to lungs, heart and spinal cord, however, may increase dose to breasts. DIBH is not always superior to FB, and the clinical significance of differences in dose to organs at risk in addition to the time required to treat patients with DIBH must be considered when deciding the most appropriate radiotherapy technique for each patient. Advances in knowledge: To our knowledge, this is the largest study comparing DIBH and FB planning for patients with lymphoma receiving mediastinal radiotherapy in clinical practice. It demonstrates the impact of an increasingly common radiotherapy technique on dose to organs at risk and the subsequent potential for long-term radiotherapy side-effects.
Habitual constipation in children as a challenge in the physiotherapist’s practice
Authors: Strojek Katarzyna 
Published: January 2021

Stool constipation, according to the opinion of GPs, pediatrics and pediatric gastroenterology specialists, is one of the most common ailments among the youngest patients. The incidence of constipation varies and depends on many factors, mainly environmental, sociological and economic ones. It also depends on the gender and age of the child. It is estimated that up to 10% of the developmental age population suffers from chronic constipation. The above-mentioned ailment is most common in children from 2 to 4 years old and is slightly more common in boys than in girls. In 90–95% of cases, constipation develops on an idiopathic functional basis [1-4].
Habitual constipation in children is a very serious clinical problem because it prevents the patient from proper functioning, and thus contributes to a reduction in life quality and lowers self-esteem. In the international literature, issues related to physiotherapeutic treatment of habitual constipation appear quite rarely. Nowadays, there has been a significant increase in the interest in improving the quality of life in the youngest patients.
An attempt to treat functional constipation in children should be made at the level of primary care, including comprehensive treatment and physiotherapy.
Sexism in the political discourse of Ukraine
Authors: Kraichynska Oleksandra , Maslova Yuliia 
Published: January 2021

The article is intended to analyze the phenomenon of sexism through the prism of political discourse in Ukraine. The specific purpose of the article was to review the involvement of women in the Verkhovna Rada of Ukraine (VRU) at the level of party lists, committees, the Office and permanent delegations. The problem of sexism among the deputies of the Verkhovna Rada was noted.
The aim of the article was to consider the manifestations of sexism in the political sphere of Ukraine. Analysis of statistics has shown that the problem of sexism is relevant today.
The author discusses the quantitative ratio of men and women among the Verkhovna Rada of Ukraine and politicians in general. Through interviews with female deputies, the author shows the problem of the discriminated. An analysis of recent media publications has shown us examples of sexism from top government positions.
As a conclusion and recommendations, the author notes the need to develop a system of civic and political education on gender equality; develop curricula on the participation of women in politics aimed at both women and men;
to carry out trainings and other types of support for women candidates; to advocate the improvement of the coverage of women-candidates in the media.
The Queer Intimacies of Roses in Louise Aston’s “Wilde Rosen” (1846) and “Die wilde Rose” (1850)
Authors: Schoppelrei Elizabeth 
Published: January 2021

Abstract
In tracing the leitmotif of wild roses in Louise Aston’s poetic oeuvre, this article insists upon new readings of Aston’s poetry that attend to the blurring of human and plant and the nonnormative intimacies found there. More specifically, I argue that the wild roses of Aston’s “Wilde Rosen” (“Wild Roses”) (1846) and “Die wilde Rose” (“The Wild Rose”) (1850) necessitate a rethinking of heteronormativity, passive femininity, intimacies, futurity, and queerness. This article understands these two poems to be practices in nonnormative intimacies and queer worldmaking: ones that weaken heteronormativity and gender roles of Vormärz Germany, stake out queer modes of existence, and unearth new ecologies. Here, I think with queer theory, feminist new materialisms, and queer ecology in close examinations of poetic diction and considerations of evolving understandings of gender and botany in the eighteenth and nineteenth centuries. If the 1800s serve as a time of shoring up and solidifying gender roles and gender meanings, Aston’s work with the cliché of women as being like flowers—in particular, wild roses—subverts hegemonic notions of passive femininity and the heteronormative impulse of such images through an expansive understanding of ecological connections and intimacies.
Traumatic Brain Injury Broadly Affects GABAergic Signaling in Dentate Gyrus Granule Cells
Authors: Parga Becerra Alejandro , Logsdon Aric F. , Banks William A. , Ransom Christopher B. 
Published: January 2021

AbstractTraumatic brain injury (TBI) causes cellular and molecular alterations that contribute to neuropsychiatric disease and epilepsy. GABAergic dysfunction figures prominently in the pathophysiology of TBI, yet the effects of TBI on tonic inhibition in hippocampus remain uncertain. We used a mouse model of severe TBI [controlled cortical impact (CCI)] to investigate GABAergic signaling in dentate gyrus granule cells (DGGCs). Basal tonic GABA currents were not affected by CCI. However, tonic currents induced by the δ subunit-selective GABAAreceptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP; 10 μm) were reduced by 44% in DGGCs ipsilateral to CCI (CCI-ipsi), but not in contralateral DGGCs. Reduced THIP currents were apparent one week after injury and persisted up to 15 weeks. The frequency of spontaneous IPSCs (sIPSCs) was reduced in CCI-ipsi cells, but the amplitude and kinetics of sIPSCs were unaffected. Immunohistochemical analysis showed reduced expression of GABAAreceptor δ subunits and GABABreceptor B2 subunits after CCI, by 43% and 40%, respectively. Activation of postsynaptic GABABreceptors caused a twofold increase in tonic currents, and this effect was markedly attenuated in CCI-ipsi cells (92% reduction). GABABreceptor-activated K+currents in DGGCs were also significantly reduced in CCI-ipsi cells, confirming a functional deficit of GABABreceptors after CCI. Results indicate broad disruption of GABAergic signaling in DGGCs after CCI, with deficits in both phasic and tonic inhibition and GABABreceptor function. These changes are predicted to disrupt operation of hippocampal networks and contribute to sequelae of severe TBI, including epilepsy.
MEKANISME GANTI RUGI DAN REHABILITASI DALAM TINDAK PIDANA PENCURIAN YANG DILAKUKAN ANAK DIBAWAH UMUR (Studi Putusan Pengadilan Negeri Cibinong No: 36/Pdt.G/2012/PN.Cbn.)
Authors: Rahmawati Dina , Burhanudin Burhanudin , Hidayatulloh Hidayatulloh 
Published: January 2021

Abstract The problem in this study is that the defendant who is underage committing a theft has been decided freely by the judge submitting compensation and rehabilitation because the defendant suffered material and immaterial losses in the Decision of the Cibinong District Court No: 36 / Pdt.G / 2012 / PN.Cbn . This study aims to understand how the compensation and rehabilitation mechanism of theft perpetrators has been dismissed freely. This study uses qualitative research methods using a normative approach. The results show that the convicted person has the right to claim compensation and rehabilitation, and compensation is directed at law enforcement or directed at the guilty party. Keyword : Compensation, Rehabilitation, Presumption not innocent Abstrak Masalah dalam penelitian ini adalah bahwa terdakwa yang di bawah umur melakukan pencurian telah diputuskan secara bebas oleh hakim yang mengajukan kompensasi dan rehabilitasi karena terdakwa menderita kerugian materi dan tidak material dalam Putusan Pengadilan Negeri Cibinong No: 36 / Pdt.G / 2012 / PN.Cbn. Penelitian ini bertujuan untuk memahami bagaimana mekanisme kompensasi dan rehabilitasi pelaku pencurian telah diberhentikan secara bebas. Penelitian ini menggunakan metode penelitian kualitatif dengan menggunakan pendekatan normatif. Hasil penelitian menunjukkan bahwa terpidana memiliki hak untuk mengklaim kompensasi dan rehabilitasi, dan kompensasi diarahkan pada penegakan hukum atau diarahkan pada pihak yang bersalah. Keyword : Kompensasi, Rehabilitasi, Praduga tidak bersalah
Genetic properties of bla CTX-M, bla SHV and bla TEM genes in ESBL producing E. coli clinical isolates
Authors: Akhvlediani Leila 
Published: January 2021

Extended-spectrum β-lactamase (ESBL) producing Escherichia coli is a serious global public health problem that requires timely and accurate control of resistant strains. This is the first report on the detection of resistant E. coli isolates in hospitals of Adjara.
We studied the genetic profile of Escherichia coli isolates producing ESBL isolated from biological samples of patients with suspected nosocomial infection in four hospitals in the Adjara region (Georgia). Identification of resistant genes was performed by multiplex PCR and reverse hybridization. Genes of the class ESBL TEM, ESBL SHV, and CTX-M were found in these samples as a result of molecular studies of genes causing genotypic correlation and resistance. Molecular genetic testing of phenotypically resistant strains of penicillin, cephalosporins of the 3rd and 4th generations, and inhibitors revealed a wide range of antibiotic resistance genes with bla CTX-M, bla TEM, bla SHV, and in two samples with genes, of ESBL class bla TEM type mutated genes: bla TEM AS104 E, bla TEM AS 238 G, bla TEM AS238 S genes.