bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compression and low velocity impact response of wood-based sandwich panels with auxetic lattice core
Authors: Smardzewski Jerzy , Maslej Michał , Wojciechowski Krzysztof W. 
Published: March 2021

AbstractThe research determined the resistance to compression and low velocity impact of wood-based sandwich panels, the face sheet made of high-density fiber board, and high pressure laminate, while its auxetic lattice core was made by 3D printing using LayWood bio-composite filament. The core's auxetic property (i.e. exhibiting negative Poisson's ratio) was observed within the planes parallel to the facings. The ability of particular types of multilayer panels to absorb the energy was also determined. Based on the analysis of the obtained test results, it was proven that the core denoted as B, with inclination angle of the cell ribs $${{\varphi }_{x}=\varphi }_{y}=65^\circ$$

φ
x

=
φ

y

=

65
∘

, shows the highest compressive strength. It was determined that the dynamic load causes a very high overload in high-density fiber board face sheets. This results in damage to the sandwich panel surface and core structure. Cells of type B favorably minimize the differences in absorbed energy when using different face sheets and the energy value for low velocity impact. Taking into account the amount of absorbed energy, the most attractive is the panel with the D-type orthotropic core characterized by an inclination angle of the cell ribs $${\varphi }_{x}= 30^\circ , {\varphi }_{y}=60^\circ$$

φ
x

=

30
∘

,

φ
y

=

60
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. The amount of energy absorbed by samples with high-density fiberboard face sheets increases significantly depending on the impactor's energy. For panels with face sheets manufactured from high-pressure laminate, the amount of energy absorbed decreases.
The burden of incontinence in a real-world data environment—insights from a digital patient companion
Authors: von Au Alexandra , Wallwiener Stephanie , Matthies Lina Maria , Friedrich Benjamin , Keim Sabine , Wallwiener Markus , Reisenauer Christl , Brugger Sarah 
Published: March 2021

Abstract
Introduction and hypothesis
Urinary incontinence (UI) has a potentially devastating effect on women’s quality of life (QoL). Conservative treatment by means of pelvic floor muscle training is the first-choice treatment modality. Nowadays, this can be supported by digital apps like pelvina©—a digital health companion pelvic floor course.

Methods
Using pelvina©, UI symptoms and QoL are regularly examined through the questionnaires QUID and SF-6D. Subsequently, we analyzed the incidence and degree of UI and its impact on QoL in 293 users in a real-world environment.

Results
The 293 patients included in this study had a median age of 36 years and a median of two children. Patients were slightly to moderately affected by UI with a QUID of 6 (2–11, maximum 24). Age and number of children were independently associated with the incidence of UI with an adjusted odds ratio (aOR) of 1.06 (95% CI 1.01–1.12) and aOR of 1.86 (95% CI 1.12–3.08). The severity of UI strongly correlated with impairment of QoL (ρ = 0.866, P < 0.001).

Conclusions
The use of real-world data generated by digital health solutions offers the opportunity to gain insight into the reality of patients’ lives. In this article, we corroborate the known associations between number of children and UI as well as the great influence UI has on QoL. This study shows that, in the future, the use of digital apps can make an important contribution to scientific data acquisition and, for example, therapy monitoring.
Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
Authors: Wimberley Catriona , Lavisse Sonia , Hillmer Ansel , Hinz Rainer , Turkheimer Federico , Zanotti-Fregonara Paolo 
Published: March 2021

Abstract
Purpose
Translocator protein 18-kDa (TSPO) imaging with positron emission tomography (PET) is widely used in research studies of brain diseases that have a neuro-immune component. Quantification of TSPO PET images, however, is associated with several challenges, such as the lack of a reference region, a genetic polymorphism affecting the affinity of the ligand for TSPO, and a strong TSPO signal in the endothelium of the brain vessels. These challenges have created an ongoing debate in the field about which type of quantification is most useful and whether there is an appropriate simplified model.

Methods
This review focuses on the quantification of TSPO radioligands in the human brain. The various methods of quantification are summarized, including the gold standard of compartmental modeling with metabolite-corrected input function as well as various alternative models and non-invasive approaches. Their advantages and drawbacks are critically assessed.

Results and conclusions
Researchers employing quantification methods for TSPO should understand the advantages and limitations associated with each method. Suggestions are given to help researchers choose between these viable alternative methods.
Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Authors: Bu Xiaoyin , Zhong Jinman , Li Weiru , Cai Shengchun , Gao Ya , Ping Baohong 
Published: March 2021

AbstractAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapeutic strategy to treat several hematological malignancies and non-hematological malignancies. However, graft-versus-host disease (GVHD) is a frequent and serious transplant-related complication which dramatically restrains the curative effect of allo-HSCT and a significant cause of morbidity and mortality in allogeneic HCT recipients. Effective prevention of GVHD mainly depends on the induction of peripheral immune tolerance. Human leukocyte antigen-G (HLA-G) is a non-classical MHC class I molecule with a strong immunosuppressive function, which plays a prominent role in immune tolerance. HLA-G triggers different reactions depending on the activation state of the immune cells and system. It also exerts a long-term immune tolerance mechanism by inducing regulatory cells. In this present review, we demonstrate the immunomodulatory properties of human leukocyte antigen-G and highlight the role of HLA-G as an immune regulator of GVHD. Furthermore, HLA-G could also serve as a good predictor of GVHD and represent a new therapeutic target for GVHD.
Exploring the intersection of functional recurrence, patient-reported sexual function, and treatment satisfaction after anterior buccal mucosal graft urethroplasty
Authors: Vetterlein Malte W. , Gödde Almut , Zumstein Valentin , Gild Philipp , Marks Phillip , Soave Armin , Meyer Christian P. , Riechardt Silke , Dahlem Roland , Fisch Margit , Kluth Luis A. ,   for the Trauma and Reconstructive Urology Working Party of the European Association of Urology Young Academic Urologists
Published: March 2021

Abstract
Purpose
To evaluate the interplay of stricture recurrence, sexual function, and treatment satisfaction after substitution urethroplasty.

Methods
Observational study of men undergoing 1-stage buccal mucosal graft urethroplasty for anterior urethral stricture between 2009 and 2016. Patients were dichotomized by self-reported treatment satisfaction. Sexual function was assessed by validated and non-validated patient-reported outcome measures. Functional recurrence was defined as symptomatic need of re-intervention. Bivariate analyses, Kaplan–Meier estimates, qualitative and quantitative analyses by uni- and multivariable regression were employed to evaluate the interplay of sexual function, functional recurrence, and treatment satisfaction.

Results
Of 534 men with bulbar (82%), penobulbar (11%), and penile strictures (7.3%), 451 (84%) were satisfied with the surgery. There were no differences in stricture location, previous treatment, graft length, or surgical technique between satisfied and unsatisfied patients (all p  ≥  0.2). Recurrence-free survival was 85% at a median follow-up of 33 mo and decreased significantly with each Likert item towards increasing dissatisfaction (p  <  0.001). Dissatisfied patients more often reported postoperative loss of rigidity, tumescence, reduced ejaculatory volume, ejaculatory pain, and reduced penile length (all p  ≤  0.042). In 83 dissatisfied men, functional recurrence (28%) and oral morbidity (20%) were the main drivers of dissatisfaction in qualitative analysis. Multivariable analyses revealed functional recurrence and impaired postoperative ejaculatory function as independent predictors of treatment dissatisfaction (all p  ≤  0.029) after adjusting for confounders.

Conclusion
We found an association of both functional success and sexual function with patient-reported treatment satisfaction after substitution urethroplasty. Such findings validate the clinical significance of defining the symptomatic need for re-intervention as an endpoint and underline the importance of further research evaluating sexual function before and after open urethral reconstruction.
Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: Recent Critical Advances in Patient Care
Authors: Cosmo Camila , Zandvakili Amin , Petrosino Nicholas J. , Berlow Yosef A. , Philip Noah S. 
Published: March 2021

Abstract
Purpose
Transcranial magnetic stimulation (TMS) is an evidence-based treatment for pharmacoresistant major depressive disorder (MDD). In the last decade, the field has seen significant advances in the understanding and use of this new technology. This review aims to describe the large, randomized controlled studies leading to the modern use of rTMS for MDD. It also includes a special section briefly discussing the use of these technologies during the COVID-19 pandemic.

Recent findings
Several new approaches and technologies are emerging in this field, including novel approaches to reduce treatment time and potentially yield new approaches to optimize and maximize clinical outcomes. Of these, theta burst TMS now has evidence indicating it is non-inferior to standard TMS and provides significant advantages in administration. Recent studies also indicate that neuroimaging and related approaches may be able to improve TMS targeting methods and potentially identify those patients most likely to respond to stimulation.

Summary
While new data is promising, significant research remains to be done to individualize and optimize TMS procedures. Emerging new approaches, such as accelerated TMS and advanced targeting methods, require additional replication and demonstration of real-world clinical utility. Cautious administration of TMS during the pandemic is possible with careful attention to safety procedures.
Engineering Students’ Perceptions of Mathematical Modeling in a Learning Module Centered on a Hydrologic Design Case Study
Authors: Merck Madeline F. , Gallagher Melissa A. , Habib Emad , Tarboton David 
Published: March 2021

AbstractEngineering students need to spend time engaging in mathematical modeling tasks to reinforce their learning of mathematics through its application to authentic problems and real world design situations. Technological tools and resources can support this kind of learning engagement. We produced an online module that develops students’ mathematical modeling skills while developing knowledge of the fundamentals of rainfall-runoff processes and engineering design. This study examined how 251 students at two United States universities perceived mathematical modeling as implemented through the online module over a 5-year period. We found, subject to the limitation that these are perceptions from not all students, that: (a) the module allowed students to be a part of the modeling process; (b) using technology, such as modeling software and online databases, in the module helped students to understand what they were doing in mathematical modeling; (c) using the technology in the module helped students to develop their skill set; and (d) difficulties with the technology and/or the modeling decisions they had to make in the module activities were in some cases barriers that interfered with students’ ability to learn. We advocate for instructors to create modules that: (a) are situated within a real-world context, requiring students to model mathematically to solve an authentic problem; (b) take advantage of digital tools used by engineers to support students’ development of the mathematical and engineering skills needed in the workforce; and (c) use student feedback to guide module revisions.
Students’ Use of Resources in a Challenge-Based Learning Context Involving Mathematics
Authors: Pepin Birgit , Kock Zeger-jan 
Published: March 2021

AbstractIn this study we use a case study approach to investigate what kinds of resources were self-reported to have been selected by students working on their Challenge-Based bachelor end projects, and how they used and orchestrated these resources. In a previous study, we had explored students’ use of resources and their Actual Student Study Paths in Calculus and Linear Algebra courses (Pepin and Kock 2019); in this study we turned to students working on their Challenge-Based bachelor end projects. Results show that the students working on Challenge-Based projects used resources outside the realm of curriculum resources offered to them in traditional courses, and the Actual Student Study Paths were iterative. We contend that ‘linear’ study paths (found e.g. in traditionally taught Linear Algebra courses) appeared to have been beneficial for students for studying particular mathematical content, which they needed for solving open challenges. In the Challenge-Based projects, the crucial resource emerged to be the tutor. We claim that this has implications for the introduction of a more Challenge-Based curriculum, where such projects would be the norm, both in terms of the professionalization of university teachers (who coach students through such projects), and for the education of students who opt for such projects: teachers have to be supported to develop as appropriate coaches in such complex environments; students have to become self-directed learners, and need to be supported with challenged-based trained coaches and teachers, in addition to be provided with suitable curricular, technological, and social resources.
William James and the Sustainable Transformation of Values, with a Case Study for Rethinking the American Dream
Authors: Croce Paul 
Published: March 2021

AbstractThis article addresses the call of the Psychology of Global Crises conference for linkage of academic work with social issues in three parts: First, examples from conference participants with their mix of bold calls for social transformation and realization of limits, a combination that generated few clear paths to achieving them. Second, presentation of Jamesian practical idealism with psychological insights for moving past impediments blocking implementation of ideals. And third, a case study of impacts from the most recent prominent crisis, the global pandemic of 2020, which threatens to exacerbate the many crises that had already been plaguing recent history. The tentacles of COVID’s impact into so many problems, starting with economic impacts from virus spread, present an opportunity to rethink the hope for constant economic growth, often expressed as the American Dream, an outlook that has driven so many of the problems surging toward crises. Jamesian awareness of the construction of ideological differences and encouragement of listening to those in disagreement provide not political solutions, but psychological preludes toward improvements in the face of crises.
Ten Myths about Medical Emergencies and Medical Kits
Authors: Hawkins Seth C. , Simon R. Bryan 
Published: March 2021

ABSTRACTWilderness medicine is plagued by myths and dogmatic teachings not supported by evidence. This article focuses particularly on those teachings and tools that would be most likely used in archaeological fieldwork. It lays out 10 of the most common and concerning myths taught in wilderness medicine and wilderness emergency medical services, both in terms of first aid and preparation of medical kits. The myths described are provide a structure for the main purpose of the article: to explain interventions and medical kit contents that are more evidence based and supported by modern understandings of wilderness medicine and fieldwork risk management. The list of top 10 myths includes (1) the use of medications other than epinephrine for anaphylaxis and (2) the availability and proper use of epinephrine auto-injectors, (3) the use of suction devices and tourniquets for snakebites, (4) the use of spinal immobilization for neck injuries, (5) the identification and treatment of heat illnesses, (6) the use of CPR in remote areas, (7) the appropriateness of dislocation reduction in remote areas, (8) the use and choice of tourniquets for arterial bleeding, (9) the initial definition and management of drowning patients, and (10) wound management myths.
Wilderness Medicine Education
Authors: Hawkins Seth C. , Winstead Corey 
Published: March 2021

AbstractWilderness medicine classes are widely available to archaeologists and field scientists, but because wilderness medicine is an unregulated field, knowing what the various courses and products mean can be difficult. Based on the education chapter in the recently published textbook Wilderness EMS, this article—written by same two authors as the book—explores a number of topics relevant for the field scientist, program director, or administrator seeking to obtain wilderness medicine training for archaeologists. The article first explores the history of wilderness medicine products and certificates available to interested parties. It then differentiates between the various products available today along with their benefits and limitations for the end user. Products and trainings described include certifications (including Wilderness First Aid [WFA], Wilderness Advanced First Aid [WAFA], Advanced Wilderness First Aid [AWFA], and Wilderness First Responder [WFR]), as well as single use or continuing education trainings (including Stop the Bleed, CPR, conference courses, and field schools). Particular attention is paid to the specific and actionable needs of a field scientist in remote areas.
Antennal transcriptome analysis and candidate olfactory genes in Crematogaster rogenhoferi
Authors: Zhou Xiang , Guo Jixing , Zhang Mingxia , Bai Chunxiu , Wang Zheng , Li Zhidong 
Published: March 2021

AbstractCrematogaster rogenhoferi (Hymenoptera: Formicidae), an omnivorous ant, is one of the dominant predatory natural enemies of a soft scale pest, Parasaissetia nigra Nietner (Homoptera: Coccidae), and can effectively control P. nigra populations in rubber forests. Olfaction plays a vital role in the process of predation. However, the information about the molecular mechanism of olfaction-evoked behaviour in C. rogenhoferi is limited. In this study, we conducted antennal transcriptome analysis to identify candidate olfactory genes. We obtained 53,892 unigenes, 16,185 of which were annotated. Based on annotations, we identified 49 unigenes related to chemoreception, including four odourant-binding proteins, three chemosensory proteins, 37 odourant receptors, two odourant ionotropic receptors and three sensory neuron membrane proteins. This is the first report on the molecular basis of the chemosensory system of C. rogenhoferi. The findings provide a basis for elucidating the molecular mechanisms of the olfactory-related behaviours of C. rogenhoferi, which would facilitate a better application of C. rogenhoferi as a biological control agent.
Variable plural marking in Palenquero Creole
Authors: Obeso Estilita María Cassiani , Smith Hiram L. 
Published: March 2021

AbstractOne of the most salient putative African features of Palenquero, an Afro-Hispanic creole spoken in northern Colombia, is the prenominal plural marker ma. However, plural number is not categorically marked with ma, which alternates with bare forms in plural contexts and also occurs in singular contexts. In a principled sample of noun phrases (n = 1,186) from the spontaneous speech of twenty-seven Palenquero-Spanish bilinguals, the rate of ma (versus zero) is 51% in plural and 13% in singular contexts. Singular ma is favored with subjects and specific objects, consistent with an association with definiteness. In plural contexts, where it is robust, selection of ma is favored with specific and generic referents in subject role. This conditioning indicates that plural marking is favored for discourse referential nouns, in accordance with the cross-linguistic generalization that morphological marking tends to appear on instances that approach the prototypical function of a category (Hopper & Thompson, 1984).
A wake-up call: playback attraction data link numbers of Mount Cameroon Francolin Pternistis camerunensis to abundance and debarking of red stinkwood Prunus africana
Authors: MAYAKA THEODORE B. , GUETSE FRANCIS , CHEMURA ABEL , TAMUNGANG RICHARD , HOŘÁK DAVID 
Published: March 2021

SummaryThe little studied Mount Cameroon Francolin Pternistis camerunensis is endangered and strictly endemic to the undergrowth of Mount Cameroon’s primary forest. We surveyed the species in the Mount Cameroon National Park in July–August 2016 using call playback at 86 plots systematically placed along 17 transects in an attempt to assess the occupancy and conservation threats to the species. The study’s three main results are as follows. Firstly, Mount Cameroon Francolin occurred in the stratified vegetation types across the altitudinal range of 1,023–2,186 m. Secondly, the response rates of francolin were 15% in submontane forest (800–1,600 m altitude range); 80.8% in montane forest (1,600–1,800 m); 3.9% in montane scrub (1,800–2,400 m); and nil in the lowland forest (0–800 m). Thirdly, bird abundance significantly increased with latitude, ground vegetation height, presence of Prunus africana and tall grass cover but decreased with the density of small trees and disturbance caused by heavy Prunus exploitation, and also, based on indirect evidence, hunting. We recommend: (1) systematic use of call playback in monitoring the population status of francolins; (2) an increase in patrolling and law enforcement to control illegal hunting, land clearance and burning of the upper slopes; (3) promotion of sustainable harvesting of Prunus and agroforestry practices aimed at curbing land clearance in the park surroundings. Further research priorities and conservation strategies have been suggested based on this study’s emerging results.
Are polarized courts dangerous for litigation? Evidence from French labor courts
Authors: Nizza Umberto 
Published: March 2021

AbstractFrance relies on unionized judges to assess labor cases in court. The economic literature advocates that judges pertaining to the more belligerent unions alter judicial equilibrium, foster lower settlements, avoid trials, and intensify a professional judge's interventions. This paper intends to test whether such speculations are accurate. The empirical evidence provided here suggests that such fears are not grounded. Using a database on French employment courts, between 2012 and 2016, we show that judges from the most adversarial trade unions foster conciliation and reduce the number of dropped legal cases. The lack of statistically significant impact of unions on the judicial institution's dysfunctions is evident: the labor judiciary's alleged polarization does not drive the rate of appeals and the number of professional judges' intervention. Finally, the judicial malfunctions appear to be driven by institutional distortions and local socio-economic conditions.