bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Percakapan Bahasa Inggris dengan Metode Dubbing bagi Siswa Darussalam Pondok Petir-Depok
Authors: Octafia Yani , Falahi Kamil , Wulandari Afrianti , Noris Shandi 
Published: October 2021

Metode pembelajaran yang diterapkan dalam Pengabdian Kepada Masyarakat ini menerapkan metode pembelajaran dubbing. Sasaran program Pengabdian Kepada Masyarakat yang akan dituju adalah para siswa kelas VII SMP di Yayasan Darussalam Pondok Petir-Depok. Kegiatan ini dilaksanakan pada tanggal 17-19 Desember 2020. Kegiatan ini bermanfaat untuk memberikan pengetahuan mengenai media dan metode pembelajaran percakapan bahasa Inggris dengan harapan dapat meningkatkan kemampuan para siswa dalam berkomunikasi dengan bahasa Inggris. Kami sebagai dosen dan mahasiswa Fakultas Sastra, jurusan Sastra Inggris, Universitas Pamulang berkontribusi dalam kegiatan ini melalui media film dengan metode dubbing untuk mengembangkan kemampuan berbicara bahasa Inggris para siswa di Yayasan Darussalam Pondok Petir-Depok. Hasil dari kegiatan ini adalah berupa membuat video pelatihan percakapan bahasa Inggris. solusi permasalahan yang diusulkan oleh kami untuk para siswa di Yayasan Darussalam Pondok Petir-Depok, yaitu para siswa dapat meningkatkan kemampuan berbicara dan menambah pembendaaraan kata sehingga dapat meningkatkan semangat para siswa dalam pelajaran bahasa Inggris di sekolah dan kehidupan sehari-hari.
Speaking Marathon: Solusi Meningkatkan Motivasi Berbicara Bahasa Inggris di Pesantren Al-Ghozali
Authors: Mahmud Lida Holida , Yamin Yamin , Anwar Mursyid , Tryana Tryana 
Published: October 2021

Berdasarkan observasi, kegiatan Pengambdian Kepada Masyarakat (PKM) di Pondok Pesantren Al-Ghozali bertujuan untuk meningkattkan kemauan berkomunikasi dengan berbicara bahasa Inggris dikalangan santri. PKM ini menggunakan metode Speaking Marathon dengan melibatkan teori Mclyntire (2007) yang menghubungkan antara kemauan berkomunikasi dengan motivasi dan kekhawatiran dan belajar. PKM ini menggunakan pendekatan simulasi melalui video pembelajaran terkait Speaking Marathon dan pendampingan. Dari hasil PKM ditemukan bahwa Speaking Marathon memberikan respon positif dalam meningkatkan kemauan berbicara siswa melalui aturan dalam metoda tersebut yang mengkesampingkan kesalahan berbahasa baik dari segi grammar, kosakata maupun pelafalan. Aturan tersebut dapat meminimalisir rasa khawatir siswa dalam melakukan kesalahan berbicara sehingga membangkitkan motivasi untuk terus berbicara dalam bahasa Inggris dengan percaya diri dan tanpa rasa takut, sehingga keraguan dan ketidakmauan berkomunikasi dalam bahasa Inggris dapat diminimalisir. Namun demikian, tetap dibutuhkan pendampingan dari guru pendamping dan ketekunan dari para siswa untuk terus berlatih dan mau belajar lebih baik lagi agar keterampilannya terus meningkat.
Konsep Work Life Balance Terhadap Produktivitas Pegawai yang Menerapkan Work From Home Pada Masa Pendemi Covid-19 (Studi Literatur)
Authors: Andriyana Ahmad Saoki , Supriansyah Supriansyah 
Published: October 2021

Pendemi Covid-19 di Indonesia menyebabkan perubahan yang amat besar dan memberikan dampak terutama dalam pelaksanaan bekerja dirumah (Work From Home) yang diharuskan oleh organisasi perusahaan. Pemberlakuan Work From Home dalam upaya memutus mata rantai penyebaran virus Covid-19 menimbulkan berbagai masalah seperti konflik keluarga, stres, distraksi konsentrasi serta sarana prasarana sebagai penunjang Work From Home yang menganggu produktivitas dan keseimbangan kehidupan pribadi. Oleh karena itu peneliti berniat untuk mengetahui konsep Work Life Balance terhadap produktivitas pegawai yang menerapkan Work From Home pada masa pendemi Covid-19. Metode penelitian ini adalah studi literatur yang didasarkan pada studi terdahulu dengan menyesuaikan kriteria yang sesuai dengan variabel yang diteliti. Pada penelitian ini didapat hasil bahwa konsep Work Life Balance dengan penggunaan waktu yang fleksibel, penerapan lingkungan yang baik, hubungan keluarga yang positif dan motivasi kerja dapat meningkatkan produktivitas pegawai yang menerapkan Work From Home.
A STUDY ON CORRELATION OF SERUM PROSTATE SPECIFIC ANTIGEN WITH CLINICAL AND PATHOLOGICAL VARIABLES IN PATIENTS OF PROSTATOMEGALY
Authors: Patidar Sanjay , Kamal Kritika , Kathota Jaydip Sinh , Tiwari Sudhanshu , Nakrani Prashant 
Published: October 2021

Background: In clinical practice, biopsies are generally performed only when the results ofprostate specific antigen (PSA) test or digital rectal examination (DRE) are abnormal. This leads to misdiagnosis of most small prostatic cancers present in many older men. Patients with lower urinary tract infection (LUTS) who have serum PSA levels higher than 4ng/ml are primarily advised to undergo prostate biopsy to rule out cancer. However, PSA is organ specific not disease specific, so the presence of other prostate diseases such as benign prostatic hyperplasia (BPH) and prostatitis may influence its effectiveness for cancer detection. Hence, the PSA based prostate cancer detection is fraught with high false positive rate.
Aim:To evaluate the utility of PSA assay as a method of investigation in diagnosis of prostatic lesion.
Objectives: The use of Serum PSA levels for the early detection of prostate cancer and evaluate its role with other modalities for diagnosis of prostate cancer and to diagnose different diseases of prostate, i.e. prostatitis, BPH in prostatomegaly, and its correlation with Serum PSA levels.
Materials and Methods: This prospective descriptive study was conducted in Index Medical College, Hospital & Research Centre, Indore, M.P,India in the period of August 2019 to July 2021. The patients were selected from the outdoor Department of General Surgery.
Results: A total of 80 male patients presenting with LUTS were included. Their mean age was 68.66 years. The majority i.e. 41 of the study group were in the age group of 61-70 years. 42 of patients had Serum PSA < 4ng/ml. Biopsy proven adenocarcinoma cases 34% of the cases are in the age group of 61-70 years. Out of the biopsy proven adenocarcinoma cases, DRE was suspicious of malignancy in 89%.
Conclusion: Serum PSA levels have a significant correlation with the age group, with the increase in age there is rise in Serum PSA levels. Transabdominal ultrasound, DRE and Serum PSA has high sensitivity in diagnosis of prostatomegaly but it was found that none of the screening tool has got much efficacy in differentiating carcinoma prostate from benign hypertrophy, but the combination of DRE and Serum total PSA or DRE, Serum total PSA and ultrasound abdomen showed higher efficacy in diagnosis of carcinoma prostate. Increase in Serum PSA is directly related to carcinoma, but there is no absolute cut-off for Serum PSAfor diagnosis of carcinoma.
Key-Words: Prostate specific antigen, Prostatomegaly, Benign Prostatic Hypertrophy, Digital Rectal Examination, International Prostate Severity Score, Carcinoma Prostate.
Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
Authors: Mendoza Carmona Laura Marcela , Marrugo Ortiz Ariel Camilo , Payares Florez Sebastian David 
Published: October 2021

Introducción: desde finales del 2019, el mundo se ha visto hostigado por la aparición de un nuevo coronavirus (SARS-CoV-2) en Wuhan, China, que se extendió globalmente y es el agente etiológico de la enfermedad conocida como COVID-19. Esta enfermedad tiene tres etapas consecutivas de gravedad y está asociada con el desarrollo del síndrome de dificultad respiratoria aguda (SDRA). Objetivo: describir las principales lesiones pulmonares, macroscópicas y microscópicas, asociadas con la infección por SARS-CoV-2, con base en hallazgos de autopsias realizadas a pacientes fallecidos por Covid-19. Métodos: se realizó una búsqueda en las bases de datos PubMed, Google Scholar, Scielo, Clinical Key y MedRxiv que incluyó artículos publicados entre el 1 de enero del 2020 y el 31 de diciembre de 2020. Resultados: el principal hallazgo macroscópico descrito fue la presencia de pulmones pesados además de superficies con áreas azul-rojizas. Se encontró en algunos casos traqueo-bronquitis y tráqueas levemente eritematosas. En hallazgos microscópicos el patrón de lesión pulmonar más común fue el daño alveolar difuso (DAD) presentado en el 88% de los casos. Se encontraron cambios en los capilares constituyendo 3 características histológicas: Lesión endotelial, alteración de las membranas de células endoteliales y angiogénesis intususceptiva. Conclusión: la gravedad de los hallazgos está determinada por la edad del paciente y el padecimiento de diversas comorbilidades/afecciones sobre todo relacionadas con el sistema respiratorio y cardiovascular, estos factores influyen en el desarrollo de hallazgos heterogéneos tanto macroscópicos como microscópicos.
Variaciones anatómicas del apéndice cecal en tomografía, un estudio retrospectivo.
Authors: De León Benedetti Laura , De León Martínez Jesus 
Published: October 2021

Introducción: la causa de dolor abdominal mayormente relacionada a cirugía es la apendicitis; su diagnóstico se ve afectado por las variaciones anatómicas del apéndice vermiforme, debido a que es el órgano abdominal con mayores variaciones en cuanto a su posición y relación con otros órganos. Objetivo: determinar las características del apéndice cecal normal en tomografías computarizadas, incluidas la longitud, el diámetro, el grosor de la pared, y la ubicación de la base y de la punta apendicular. Métodos: se estudiaron tomografías computarizadas abdominales con imágenes del protocolo de exploración UroCT para identificar la localización de la base y la punta, y medir longitud, ancho y diámetro del apéndice cecal. La ubicación de la punta se categorizó como anterior o posterior y se subdividió en: pélvica, retrocecal/retrocólica, postileal, paracólica, subcecal, subhepática o línea media. La localización de la base apendicular se definió en tres planos en relación con la válvula ileocecal: antero-posterior, medial-lateral o superior-inferior. Resultados: fueron incluidas tomografías abdominales de 83 pacientes en las que se determinaron las características generales del apéndice cecal: se observó una longitud media de 78 mm (DE = 23,41) y diámetro medio de 6,55 mm (DE= 1,77). Las bases tuvieron con mayor frecuencia una localización inferior posterior, lateral y medial a la válvula ileocecal, las puntas estuvieron más frecuentemente localizadas en la cavidad pélvica, seguidas de localizaciones retrocecal y paracecal. Conclusión: la localización de la base del apéndice se correlaciona con lo descrito en estudios previos. No existe correlación entre la ubicación de la punta y la longitud del apéndice, esto significa que, incluso si el apéndice es largo, no se asocia con una ubicación de la punta más alejada de la válvula ileocecal.
Trombosis venosa profunda de miembros inferiores asociada a una triple deficiencia enzimática: antitrombina III, proteína C y proteína S. Reporte de caso
Authors: Franco Díaz de León Raúl , Gamboa Solís Raúl , Sánchez Díaz de León Jose Antonio , Laurel Razo Aldo 
Published: October 2021

La Enfermedad Tromboembólica Venosa comprende dos trastornos, el Tromboembolismo Pulmonar y la Trombosis Venosa Profunda (TVP). Esta última se asocia, entre otras causas, a deficiencias enzimáticas del organismo, las cuales favorecen el desarrollo de la enfermedad y sus complicaciones, siendo el síndrome postrombótico la más frecuente. Presentamos el caso de un paciente masculino de 34 años que acude a consulta por presentar aumento de volumen, edema, tensión muscular, dolor y claudicación de ambas extremidades pélvicas a quien se le diagnosticó Trombosis Venosa Profunda Fémoro-Iliaca Bilateral asociado a una triple deficiencia enzimática de Antitrombina III, Proteína C y Proteína S de la coagulación.
Лісівничо-селекційна оцінка плюсового насадження сосни звичайної, ураженого кореневою губкою, в ДП «Рокитнівське лісове господарство»
Authors: Lazar О. D. 
Published: October 2021

У статті наведено лісівничо-селекційну характеристику плюсового насадження сосни звичайної, ураженого кореневою губкою, в Карпилівському лісництві ДП «Рокитнівське лісове господарство». Насадження природного походження у віці 95 років росте за І класом бонітету, має повноту 0,6. У 73 % дерев відсутні вади стовбура й крони. Серед них відібрано неушкоджені дерева І і ІІ селекційних категорій, які рекомендовано внести до Державного реєстру та використовувати як генетичний матеріал для подальших досліджень, заготівлі насіння й живців із метою створення лісонасінних плантацій та створення стійких насаджень.
Агрохімічні характеристики ґрунтів лісоаграрного стаціонару ДП «Маріупольська лісова науково-дослідна станція»
Authors: Solomakha N. G. , Korotkova T. M. , Kravchenko V. M. , Ivanicheva Ye. V. 
Published: October 2021

Наведено результати досліджень агрохімічних показників чорноземів на ріллі й у полезахисних лісових смугах (ПЛС) ДП «Маріупольська ЛНДС» та фермерського господарства с. Новотроїцьке Волноваського району Донецької області (контроль). Вміст гумусу у ґрунтах ПЛС ДП «Маріупольська ЛНДС» є вищим, ніж на ріллі, на 6,06 % і становить у середньому 11,72 %. На контролі вміст гумусу на ріллі й у ПЛС різниться неістотно (середнє значення 6,0 %). Кореляційний зв’язок між вмістом гумусу і віком ПЛС є сильним (r = 0,7; trфакт. ? trтеор). На дослідних об’єктах реакція ґрунтового розчину ріллі становить 6,8–7,75 (рН водний), 5,7–6,8 (рН сольовий), у насадженнях – 6,2–7,75 (рН водний), 5,25–7,0 (рН сольовий). Вміст азоту і калію є більшим у ґрунтах ПЛС, фосфору – на ріллі. Для ґрунтів ПЛС кореляційний зв’язок між вмістом азоту і віком насадження, вмістом гумусу й азоту має середню силу (r = 0,6; trфакт. ? trтеор). Виявлено зворотній кореляційний зв'язок середньої сили між умістом гумусу і рН сольовим у ґрунтах на ріллі (r = 0,5; trфакт. ? trтеор).
Alternative Database Structures for Prosopographical Research
Authors: Baillie James 
Published: October 2021

As digital prosopography has developed as a discipline in historical research over the last three decades, and as changes in technology have provided more options for its underlying systems, the potential scope of the field has expanded likewise. This expansion in both what can be done and how it can be done creates new questions of how to select data models and technical infrastructure, and what the implications of those models are for different use cases and forms of analysis. This article discusses current prosopographical systems, largely built with relational databases using the factoid model, and suggests use cases for alternatives and when and why these may be used. In particular, it argues that encoding secondary historical reasoning within a dataset to create databases of single, coherent source readings can be important to facilitate analyses that would face difficulties when applied factoid data. In this discussion, a number of novel distinctions are drawn between purposes and models for prosopographical projects as a suggestion towards a clearer framing of future discussions in this area.
Features of the expanded collective management of copyright and (or) related rights objects under the updated legislation of Ukraine
Authors: Kostiv Oleksandr 
Published: October 2021

Keywords: collective management of rights, copyright and related rights, extendedmanagement, organization of collective management, accreditation of the organization,remuneration, revocation of rights
The article examines the features of extended collective management of copyright and (or)related rights, as one of collective management types provided by the updated legislationof Ukraine in the study area. The author points out that the expanded collectivemanagement extends to the entire territory of Ukraine and is carried out on the propertyrights of all right holders in the relevant category in the areas for which the organizationis accredited, including those who have not concluded an agreement onmanagement of copyright and (or) related rights with an accredited organization, regardlessof the method chosen by such right holders to manage their rights.Among the areas of expanded collective management are: public performance ofmusical non-dramatic works with text and without text, including those works thatare included in the audiovisual works; public announcement of musical non-dramaticworks with and without text, including those works that are included in the audiovisualworks, except for cable retransmission; the right to a fair remuneration, commonto performers and producers of phonograms (videograms), for the public performance of phonograms and performances recorded in them or a public demonstration ofvideograms and performances recorded therein, published for commercial use; theright to a fair remuneration common to performers and producers of phonograms(videograms) for the public notification of phonograms and their recorded performances,videograms and fixed performances published for commercial purposes otherthan cable retransmission.Analysing the areas of expanded collective management, the author concludes thatthe position of the legislator in the question of completeness of the list of such areas isright, although the areas themselves, in the author's opinion, are not quite correctlydefined. Agreed that expanded collective management somewhat limits the rights ofthe right holder, the list completeness of its application areas contributes to the clarityof its application and does not create risks of involving other areas by analogy. Theauthor notes that for each area of extended collective management, one accredited organizationis determined in the case of absence of any conflicts of interest between themain category of right holders, in whose interests such an organization operates, andother categories of right holders. The remuneration collection system during extendedcollective management is also analysed by the author.Considerable attention in the study is paid to the issue of legal status and featuresof the additional accredited organization. Determinant in the issue of effective managementof copyright and related rights is the right holder’s right to revoke his rightsfrom an additional accredited organization.
A Novel Mitochondrial-Related Nuclear Gene Signature Predicts Overall Survival of Lung Adenocarcinoma Patients
Authors: Zhang Xiangwei , Dong Wei , Zhang Jishuai , Liu Wenqiang , Yin Jingjing , Shi Duozhi , Ma Wei 
Published: October 2021

Background: Lung cancer is the leading cause of cancer-related death worldwide, of which lung adenocarcinoma (LUAD) is one of the main histological subtypes. Mitochondria are vital for maintaining the physiological function, and their dysfunction has been found to be correlated with tumorigenesis and disease progression. Although, some mitochondrial-related genes have been found to correlate with the clinical outcomes of multiple tumors solely. The integrated relationship between nuclear mitochondrial genes (NMGs) and the prognosis of LUAD remains unclear.Methods: The list of NMGs, gene expression data, and related clinical information of LUAD were downloaded from public databases. Bioinformatics methods were used and obtained 18 prognostic related NMGs to construct a risk signature.Results: There were 18 NMGs (NDUFS2, ATP8A2, SCO1, COX14, COA6, RRM2B, TFAM, DARS2, GARS, YARS2, EFG1, GFM1, MRPL3, MRPL44, ISCU, CABC1, HSPD1, and ETHE1) identified by LASSO regression analysis. The mRNA expression of these 18 genes was positively correlated with their relative linear copy number alteration (CNA). Meanwhile, the established risk signature could effectively distinguish high- and low-risk patients, and its predictive capacity was validated in three independent gene expression omnibus (GEO) cohorts. Notably, a significantly lower prevalence of actionable EGFR alterations was presented in patients with high-risk NMGs signature but accompanied with a more inflame immune tumor microenvironment. Additionally, multicomponent Cox regression analysis showed that the model was stable when risk score, tumor stage, and lymph node stage were considered, and the 1-, 3-, and 5-year AUC were 0.74, 0.75, and 0.70, respectively.Conclusion: Together, this study established a signature based on NMGs that is a prognostic biomarker for LUAD patients and has the potential to be widely applied in future clinical settings.
Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway
Authors: Zhang Mian , Lei Yi-shan , Meng Xiao-wen , Liu Hua-yue , Li Lin-gui , Zhang Jun , Zhang Jia-xin , Tao Wen-hui , Peng Ke , Lin Jun , Ji Fu-hai 
Published: October 2021

Background: NLRP3 inflammasome contributes a lot to sterile inflammatory response and pyroptosis in ischemia/reperfusion (I/R) injury. Cardiac fibroblasts (CFs) are regarded as semi-professional inflammatory cells and they exert an immunomodulatory role in heart. Iguratimod provides a protective role in several human diseases through exerting a powerful anti-inflammatory effect. However, it is still unclear whether iguratimod could alleviate myocardial I/R injury and whether inflammation triggered by NLRP3-related pyroptosis of CFs is involved in this process.Methods: Transcriptomics analysis for GSE160516 dataset was conducted to explore the biological function of differentially expressed genes during myocardial I/R. In vivo, mice underwent ligation of left anterior descending coronary artery for 30 min followed by 24 h reperfusion. In vitro, primary CFs were subjected to hypoxia for 1 h followed by reoxygenation for 3 h (H/R). Iguratimod was used prior to I/R or H/R. Myocardial infarct area, serum level of cardiac troponin I (cTnI), pathology of myocardial tissue, cell viability, lactate dehydrogenase (LDH) release, and the expression levels of mRNA and protein for pyroptosis-related molecules were measured. Immunofluorescence was applied to determine the cellular localization of NLRP3 protein in cardiac tissue.Results: During myocardial I/R, inflammatory response was found to be the most significantly enriched biological process, and nucleotide-binding oligomerization domain (NOD)-like receptor signaling was a crucial pathway in mediating cardiac inflammation. In our experiments, pretreatment with iguratimod significantly ameliorated I/R-induced myocardial injury and H/R-induced pyroptosis of CFs, as evidenced by reduced myocardial infarct area, serum cTnI level, and LDH release in supernatants, as well as improved pathology of cardiac tissue and cell viability. Immunofluorescence analysis showed that NLRP3 was mainly localized in CFs. Moreover, iguratimod inhibited the expression of pro-inflammatory cytokines and pyroptosis-related molecules, including NLRP3, cleaved caspase-1, and GSDMD-N.Conclusion: Our results suggested that inflammatory response mediated by NOD-like receptor signaling is of vital importance in myocardial I/R injury. Iguratimod protected cardiomyocytes through reducing the cascade of inflammation in heart by inhibiting cardiac fibroblast pyroptosis via the COX2/NLRP3 signaling pathway.