bluuebunny/crossref_metadata_2025_split huggingface dataset:
EARLY STOMACH CANCER DIAGNOSTICS TREATMENT PREVENTION
Authors:   Dnieper Medical Institute of Traditional and Alternative Medicine, Dnipro, Filippov Y. A. , Evtushenko T. V. ,   Dnieper Medical Institute of Traditional and Alternative Medicine, Dnipro
Published: November 2021

Keywords: Stomach cancer (Carcinoma ventriculi), early diagnosis, vortex magnetic field The presented data allow us to solve the main problems in the fight against stomach cancer. 1.	Early diagnosis is very important in the stomach cancer timely treatment. Implementation of the early diagnosticsis relevant in the future of preserving the country’s population health. The use of prediction capabilities in the distribution of the population into risk groups with the allocation of a high risk group should be effective. The diagnosis quality depends on gastroscopy, exfoliative cytological or histological examination of gastrobiopsy material, determination of tumor markers (Cancer Embryonic Antigen, Specific Antigen-72-4). 2.	Damaging factors action prevention on the gastric mucosa when using a magnetotherapy apparatus with a vortex component “Vitma-1”. Alternating vortex magnetic field, the proteolytic activity of gastric juice changes. It is possible to suppress the increased aggressiveness of the acid-peptic factor, which accompanies gastric ulcer and duodenal ulcer; or to stimulate a pepsin activity increase in case of a decrease in the gastric juice proteolytic activity. 3.	A significant role is assigned to a specific diet and the natural herbal remedies use in the risk group for the disease prevention.
Acute Hemodynamic Responses to Enhanced External Counterpulsation in Patients With Coronary Artery Disease
Authors: Zhang Yahui , Chen Ziqi , Mai Zhouming , Zhou Wenjuan , Wang Hui , Zhang Xiaodong , Wei Wenbin , Du Jianhang , Wu Guifu 
Published: November 2021

Purpose: Enhanced external counterpulsation is a non-invasive treatment that increases coronary flow in patients with coronary artery disease (CAD). However, the acute responses of vascular and blood flow characteristics in the conduit arteries during and immediately after enhanced external counterpulsation (EECP) need to be verified.Methods: Forty-two patients with CAD and 21 healthy controls were recruited into this study to receive 45 min-EECP. Both common carotid arteries (CCAs), namely, the left carotid (LC) and right carotid (RC), the right brachial (RB), and right femoral (RF) artery were imaged using a Color Doppler ultrasound. The peak systolic velocity (PSV), end-diastolic velocity (EDV), mean inner diameter (ID), resistance index (RI), and mean flow rate (FR) were measured and calculated before, during, and after the 45 min-EECP treatment.Results: During EECP, in the CCAs, the EDV was significantly decreased, while the RI was markedly increased in the two groups (both P &lt; 0.01). However, immediately after EECP, the RI in the RC was significantly lower than that at the baseline in the patients with CAD (P = 0.039). The FR of the LC was markedly increased during EECP only in the CAD patients (P = 0.004). The PSV of the patients with CAD was also significantly reduced during EECP (P = 0.015) and immediately after EECP (P = 0.005) compared with the baseline. Moreover, the ID of the LC, RB, and RF was significantly higher immediately after EECP than that at the baseline (all P &lt; 0.05) in the patients with CAD. In addition, they were also higher than that in the control groups (all P &lt; 0.05). Furthermore, by the subgroup analysis, there were significant differences in the FR, PSV, and RI between females and males during and immediately after EECP (all P &lt; 0.05).Conclusions: Enhanced external counterpulsation creates different responses of vascular and blood flow characteristics in carotid and peripheral arteries, with more significant effects in both the carotid arteries. Additionally, the beneficial effects in ID, blood flow velocity, RI, and FR after 45 min-EECP were shown only in the patients with CAD. More importantly, acute improvement of EECP in the FR of the brachial artery was showed in males, while the FR and RI of the carotid arteries changed in females.
Association of Systemic Immune-Inflammation Index With Short-Term Mortality of Congestive Heart Failure: A Retrospective Cohort Study
Authors: Tang Yiyang , Zeng Xiaofang , Feng Yilu , Chen Qin , Liu Zhenghui , Luo Hui , Zha Lihuang , Yu Zaixin 
Published: November 2021

Purpose: The present study aimed to clarify the potential predictive significance of Systemic immune-inflammation index (SII) in assessing the poor prognosis of critically ill patients with congestive heart failure (CHF).Methods: Detailed clinical data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care III database after gaining access and building the local platform. The 30- and 90-day and hospital all-cause mortalities of the patient was the primary outcome, and the readmission rate and the occurrence of major cardiovascular adverse events (MACEs) were the secondary outcomes. the Cox proportional hazard model and Logistic regression analysis were selected to reveal the relationship between SII level and the research outcome. Further, the propensity score matching (PSM) analysis was performed to improve the reliability of results by reducing the imbalance across groups.Results: There were a total of 4,606 subjects who passed the screening process and entered the subsequent analysis. Multivariate regression analysis showed that after adjusting for possible confounders, including age, heart rate, and albumin, etc., the high level of SII was independently associated with 30- and 90-day and hospital mortalities (tertile 3 vs. tertile 1: HR, 95% CIs: 1.23, 1.04-1.45; 1.21, 1.06-1.39; 1.26, 1.05-1.50) and the incidence of MACEs (tertile 3 vs. tertile 1: OR, 95% CI: 1.39, 1.12-1.73) in critically ill patients with CHF, but no significant correlation was found between SII and the readmission rate. Consistently, patients with high SII level still presented a significantly higher short-term mortality than patients with low SII in the PSM subset.Conclusion: In critically ill patients with CHF, high level of SII could effectively predict high 30- and 90-day and hospital mortalities, as well as the high risk of occurrence of MACEs.
Myocardial Viability, Functional Status, and Collaterals of Patients With Chronically Occluded Coronary Arteries
Authors: Yang Xueyao , Tian Jinfan , Zhang Lijun , Dong Wei , Mi Hongzhi , Li Jianan , Li Jiahui , Han Ye , Zuo Huijuan , An Jing , He Yi , Song Xiantao 
Published: November 2021

Objective: Viability and functional assessments are recommended for indication and intervention for chronic coronary total occlusion (CTO). We aimed to evaluate myocardial viability and left ventricular (LV) functional status by using cardiovascular magnetic resonance (CMR) and to investigate the relationship between them and collaterals in patients with CTO.Materials and Methods: We enrolled 194 patients with one CTO artery as detected by coronary angiography. Patients were scheduled for CMR within 1 week after coronary angiography.Results: A total of 128 CTO territories (66%) showed scar based on late gadolinium enhancement (LGE) imaging. There were 1,112 segments in CTO territory, while only 198 segments (18%) subtended by the CTO artery showed transmural scar (i.e., &gt;50% extent on LGE). Patients with viable myocardium had higher LV ejection fraction (LVEF) (56.7 ± 13.5% vs. 48.3 ± 15.4%, p &lt; 0.001) than those with transmural scar. Angiographically, well-developed collaterals were found in 164 patients (85%). There was no significant correlation between collaterals and the presence of myocardial scar (p = 0.680) or between collaterals and LVEF (p = 0.191). Nevertheless, more segments with transmural scar were observed in patients with poorly-developed collaterals than in those with well-developed collaterals (25 vs. 17%, p = 0.010).Conclusion: Myocardial infarction detected by CMR is widespread among patients with CTO, yet only a bit of transmural myocardial scar was observed within CTO territory. Limited number of segments with transmural scar is associated with preserved LV function. Well-developed collaterals are not related to the prevalence of myocardial scar or systolic functioning, but could be related to reduce number of non-viable segments subtended by the CTO artery.
The Outcomes of Total Anomalous Pulmonary Venous Connection in Neonates−10-Year Experience at a Single Center
Authors: Ji Erchao , Qiu Hailong , Liu Xiaobing , Xie Wen , Liufu Rong , Liu Tao , Chen Jimei , Wen Shusheng , Li Xiaohua , Cen Jianzheng , Zhuang Jian 
Published: November 2021

Background: Recent developments in surgical techniques and hospital care have led to improved outcomes following repair of total anomalous pulmonary venous connection (TAPVC). However, surgical repair of neonatal TAPVC remains associated with a high risk of postoperative mortality and pulmonary venous obstruction (PVO). We conducted this retrospective study to identify risk factors associated with surgical outcomes in the neonatal population.Methods: A retrospective review was conducted for all 127 neonates who underwent operations for isolated TAPVC from January 2009 to January 2019.Results: Preoperative PVO occurred in 33 (26.0%) of the 127 patients. Fifty patients (39.4%) required tracheal intubation before the operation. Twenty-three patients (18.1%) underwent emergency surgery. There were 11 (8.7%) early deaths. Significant risk factors were prolonged cardiopulmonary bypass (CPB) time (p = 0.013) and increased postoperative central venous pressure (CVP, p = 0.036). There were 5 (4.3%) late deaths within 1 year of repair. The risk factors for overall death were preoperative acidosis (p = 0.001), prolonged CPB time (p &lt; 0.001) and increased postoperative CVP (p = 0.007). In particular, mortality was significantly higher (p = 0.007) with a postoperative CVP &gt; 8 mmHg. With an increase in use of sutureless techniques (p = 0.001) and decrease in deep hypothermic circulatory arrest (p = 0.009) over the past 5 years, postoperative mortality greatly decreased (21.2%: 6.7%, p = 0.016). Postoperative PVO occurred in 15 patients (11.8%). Risk factors were mixed TAPVC (p = 0.037), preoperative acidosis (p = 0.001) and prolonged CPB time (p = 0.006).Conclusion: Although postoperative mortality of neonatal TAPVC has dropped to 6.7% over the past 5 years, it is still relatively high. Risk factors for postoperative death include preoperative acidosis, prolonged CPB time and increased postoperative CVP. Mortality was significantly higher for neonates with an average CVP &gt; 8 mmHg 24 h after surgery.
Local and Distributed Machine Learning for Inter-hospital Data Utilization: An Application for TAVI Outcome Prediction
Authors: Lopes Ricardo R. , Mamprin Marco , Zelis Jo M. , Tonino Pim A. L. , van Mourik Martijn S. , Vis Marije M. , Zinger Svitlana , de Mol Bas A. J. M. , de With Peter H. N. , Marquering Henk A. 
Published: November 2021

Background: Machine learning models have been developed for numerous medical prognostic purposes. These models are commonly developed using data from single centers or regional registries. Including data from multiple centers improves robustness and accuracy of prognostic models. However, data sharing between multiple centers is complex, mainly because of regulations and patient privacy issues.Objective: We aim to overcome data sharing impediments by using distributed ML and local learning followed by model integration. We applied these techniques to develop 1-year TAVI mortality estimation models with data from two centers without sharing any data.Methods: A distributed ML technique and local learning followed by model integration was used to develop models to predict 1-year mortality after TAVI. We included two populations with 1,160 (Center A) and 631 (Center B) patients. Five traditional ML algorithms were implemented. The results were compared to models created individually on each center.Results: The combined learning techniques outperformed the mono-center models. For center A, the combined local XGBoost achieved an AUC of 0.67 (compared to a mono-center AUC of 0.65) and, for center B, a distributed neural network achieved an AUC of 0.68 (compared to a mono-center AUC of 0.64).Conclusion: This study shows that distributed ML and combined local models techniques, can overcome data sharing limitations and result in more accurate models for TAVI mortality estimation. We have shown improved prognostic accuracy for both centers and can also be used as an alternative to overcome the problem of limited amounts of data when creating prognostic models.
Effects of Midazolam on the Development of Adult Leydig Cells From Stem Cells In Vitro
Authors: Zhao Xingyi , Ji Minpeng , Wen Xin , Chen Dan , Huang Fu , Guan Xiaoju , Tian Jing , Xie Jiajia , Shao Jingjing , Wang Jiexia , Huang Luoqi , Lin Han , Ye Leping , Chen Haolin 
Published: November 2021

BackgroundMidazolam is a neurological drug with diverse functions, including sedation, hypnosis, decreased anxiety, anterograde amnesia, brain-mediated muscle relaxation, and anticonvulsant activity. Since it is frequently used in children and adolescents for extended periods of time, there is a risk that it may affect their pubertal development. Here, we report a potential effect of the drug on the development of Leydig cells (LCs), the testosterone (T)-producing cells in the testis.MethodsStem LCs (SLCs), isolated from adult rat testes by a magnetic-activated cell sorting technique, were induced to differentiate into LCs in vitro for 3 weeks. Midazolam (0.1–30 μM) was added to the culture medium, and the effects on LC development were assayed.ResultsMidazolam has dose-dependent effects on SLC differentiation. At low concentrations (0.1–5 μM), the drug can mildly increase SLC differentiation (increased T production), while at higher concentrations (15–30 μM), it inhibits LC development (decreased T production). T increases at lower levels may be due to upregulations of scavenger receptor class b Member 1 (SCARB1) and cytochrome P450 17A1 (CYP17A1), while T reductions at higher levels of midazolam could be due to changes in multiple steroidogenic proteins. The uneven changes in steroidogenic pathway proteins, especially reductions in CYP17A1 at high midazolam levels, also result in an accumulation of progesterone. In addition to changes in T, increases in progesterone could have additional impacts on male reproduction. The loss in steroidogenic proteins at high midazolam levels may be mediated in part by the inactivation of protein kinase B/cAMP response element-binding protein (AKT/CREB) signaling pathway.ConclusionMidazolam has the potential to affect adult Leydig cell (ALC) development at concentrations comparable with the blood serum levels in human patients. Further studies are needed to test the effects on human cells.
Experimental Study on Sweep Characteristics of Gas Gravity Drainage in the Interlayer Oil Reservoir
Authors: Yu Hongwei , Wang Lu , Zhou Daiyu , Wang Fuyong , Li Shi , Li Jun , Chen Xinglong , Cao An , Han Haishui 
Published: November 2021

Stable gas gravity drainage is considered an effective method to enhance oil recovery, especially suitable for deep buried, large dip angle, and thick oil reservoirs. The influence of reservoir heterogeneity on controlling the gas–oil interface and sweep characteristics of injected gas is particularly important to design reservoir development schemes. In this study, according to the interlayer characteristics of Donghe carboniferous oil reservoirs in the Tarim Basin, NW China, 2D visual physical models are established, in which the matrix permeability is 68.1 mD and average pore throat radius is 60 nm. Then, hydrocarbon gas gravity drainage simulation experiments are carried out systematically, and a high-speed camera is used to record the process of gas–oil flow and interface movement. In this experiment, the miscible zone of crude oil and hydrocarbon gas is observed for the first time. The interlayer has an obvious shielding influence, which can destroy the stability of the gas–oil interface and miscible zone, change the movement direction of the gas–oil interface, and reduce the final oil recovery after gravity drainage. The remaining oil mainly is distributed near the interlayers. The higher displacement pressure leads to increased stability of the gas–oil displacement front and later gas breakthrough, which leads to higher oil recovery. The lower gas injection rate contributes to a slower front velocity and wider miscible zone, which could delay gas breakthrough. For the immiscible gas gravity drainage, there is a critical gas injection rate, with which the oil recovery factor is the highest.
Vertical Structure of a Snowfall Event Based on Observations From the Aircraft and Mountain Station in Beijing
Authors: Huang Yu , Zhao Delong , Du Yuanmou , Chen Yichen , Zhang Lei , Li Xia , Jing Yingying 
Published: November 2021

An aircraft platform, ground-based disdrometer, cloud radar, radiometer, and automatic station were combined to study a snowfall case (16:30–21:00 observed by ground cloud radar) on the Yangqing Mountains in Beijing. Comparing the variation of ice habit and number concentration at aircraft altitude (2.9–3.2 km) and ground, we discussed the ice growth mechanisms in the Beijing Mountains. Results indicated that the snowfall was steady but not strong with reflectivity less than 20dBZ, and cloud top altitude less than 4.5 km. The number concentrations for both liquid and ice crystals at aircraft altitude and ground were very similar, both dominated by small particles at diameters of 0.1–1.2 mm, and the proportion of mean number concentrations at small diameters both in the aircraft and on the ground was large, peaking at 44 L−1 mm−1 and 8826 L−1 mm−1 respectively, and decreased rapidly as the diameter increased. There was no mixed phase in clouds with little liquid water. Particles were relatively regular, and were transparent with dendritic and disk-hexagonal shapes. The ice crystals and snowflakes were mainly grown by the deposition and aggregation, rarely by the riming process, and no secondary ice formation was observed.
Process Evaluation of Internet-Based Cognitive Behavioral Therapy Intervention for Informal Caregivers
Authors: Biliunaite Ieva , Kazlauskas Evaldas , Sanderman Robbert , Andersson Gerhard 
Published: November 2021

Background: Informal caregivers are individuals who provide care for ill, frail, or otherwise dependent family members, siblings, or friends. Due to the caregiving demands, informal caregivers are known to experience negative mental health symptoms, such as stress or anxiety. Interventions based on Internet-based Cognitive Behavioral Therapy (ICBT) principles have been previously found to be effective for different populations and could also be considered as a plausible support option for informal caregivers. However, findings regarding effectiveness alone might not be sufficient for informing about the overall feasibility of the intervention.Objective: The aim of this process evaluation study was to evaluate the feasibility of a previously developed ICBT intervention for informal caregivers in Lithuania. More specifically, we evaluated the suitability of the intervention in relation to its content and delivery mode.Methods: Two studies were conducted. Study 1 consisted of participant evaluations of an 8-week, 8-module long therapist supported ICBT intervention. Evaluations for the Study 1 were retrieved from previously unused data, obtained from pilot testing of the intervention in which 63 informal caregivers took part. The evaluations contained of qualitative data (participant comments), as well as quantitative data (evaluations of each of the sessions). The Study 2 was an online stakeholder focus-group discussion conducted via Zoom. Eight stakeholders took part in the discussion, among whom there were social workers, medical professionals as well as individuals with caregiving experience themselves. Data were analyzed using descriptive statistics, thematic analysis, and data coding.Results: Results of the Study 1 showed that most of the pilot randomized controlled trial participants evaluated content and format of the intervention positively. These results were complemented by the findings in the Study 2, in which stakeholders evaluated the intervention as suitable and promising. In addition, stakeholders made certain suggestions for improving the intervention's usability for the informal caregivers. This included improving the instructions, providing with more guidance, and considering personalization options.Conclusion: The process evaluation helped to evaluate the feasibility of the ICBT intervention for informal caregivers in Lithuania from the two perspectives: users and stakeholders. Our findings suggest that the intervention is suitable for the target population.
18F-FDG PET/CT in a Patient With Malignant Pheochromocytoma Recurrence and Bone Metastasis After Operation—Case Report and Review of the Literature
Authors: Feng Bei , Chen Maojia , Jiang Yanghongyan , Hui Yongfeng , Zhao Qian 
Published: November 2021

Introduction: Bone metastasis of malignant pheochromocytoma is a rare disease. We report a patient with a 10-year history who underwent 18F-FDG PET/CT to detect bone metastasis and receive radiotherapy and chemotherapy with complete response for bilateral iliac pain.Case presentation: A 48-year-old male patient complained of dizziness, hypertension, and bilateral iliac pain for 2 months. The patient had a history of resection of bilateral malignant adrenal pheochromocytoma 10 years earlier, and all complaints were relieved immediately after operation. 18F-FDGPET/CT showed abdominal lymph node uptake and multiple bone uptake, as well as multiple brown fat uptake. A biopsy of the left ilium confirms the metastasis of malignant pheochromocytoma.Discussion: In our literature review, we discuss the metastasis of pheochromocytoma reported by some scholars, and the role of radionuclides such as 18F-FDG PET/CT, 18F-DOPA PET/CT, I-123MIBG, and 68Ga-DOTATATE PET, in the diagnosis of malignant pheochromocytoma. The patient above is a good case for clinicians in the diagnosis and treatment of metastatic pheochromocytoma, especially in some hospitals with only 18F-FDG imaging agents.Conclusion: A review of this case and similar rare cases in the literature illustrates the importance of 18F-FDG PET/CT in the diagnosis of malignant pheochromocytoma.