bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tingkat Pengetahuan Dan Sikap Ibu Menghadapi Masa Menopause
Authors: Cipto Cipto , Siswoko Siswoko , Saptaningrum Epi 
Published: March 2021

ABSTRACTBackground: Life is a process of continuous change from birth to death. One of the changes that are unavoidable and will face a woman is menopausal. Results of preliminary studies have been conducted in the village Kunduran showed that of 10 postmenopausal women (aged 45-55 years) is known that most do not know about menopause.Objectives: The general objective of the study was to determine the knowledge and attitude of mothers facing menopause. Interest in particular know the characteristics of respondents by education, employment, knowledge level and attitude of the mother in the face menopause.Methods: The study was a descriptive study using cross sectional method, the type of design that survey. Population is the mother menopause aged 40-45 years. Samples obtained through purposive sampling techniques, descriptive analysis with frequency destribusi.Results: The characteristics of respondents in terms of maternal education level premenopausal with basic education as much as 56 respondents (70%). While the work of the mother is a housewife 43 respondents (53.8%). The level of knowledge of mothers premenopausal good category 47 respondents (58.8%). Premenopausal mothers positive attitude as much as 47 respondents (58.8%). Keywords: Knowledge, Attitude, menopause
Álvaro Vieira Pinto on the concept of technology: an introductory discussion
Authors: Da Costa Breno Augusto , Martins Adriano Eurípedes Medeiros 
Published: March 2021

Álvaro Vieira Pinto sobre o conceito de tecnologia: uma discussão introdutória
Esse artigo tem o objetivo de discutir o conceito de tecnologia provido pelo filósofo brasileiro Álvaro Vieira Pinto. Primeiramente, vida e obra do filósofo são apresentadas, seu livro “O conceito de tecnologia” e seus fundamentos metodológicos são brevemente examinados e, finalmente, discute-se sua conceituação de tecnologia. Dos quatros significados do termo desvelados pelo autor, destaca-se tecnologia como sendo o “logos da técnica”, já que é ela proposta como um campo unitário de estudo do tema em questão. Na conclusão, aponta-se a riqueza de suas reflexões para a libertação dos países subdesenvolvidos.
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Artigo em inglês.
O que nos fazem pensar Exu e Criolo?
Authors: Fernandes Alexandre de Oliveira 
Published: March 2021

Dialogo com a Tese de doutoramento intitulada “Nos (Des)Caminhos da Exu: poética: As encruzilhadas afrossurrealistas da criação de Criolo”. Produzo comentários à moda de Roland Barthes e enxerto minha leitura à tese, buscando um efeito de transbordamento textual. No presente texto que não é mais do que um possível prefácio ou uma nota de rodapé, para refletir sobre a tese em tela, utilizo-me de uma “an-arquitetura” derridiana e, ao seguir os rastros da escritura de Andrade, componho um pensamento outro nos limites da forma de pensar, de articular e de escrever uma tese. Trata-se de uma “promessa” sustentada por um texto-comentário, um “enxerto” generalizado, cujo movimento não tem começo, não tem fim nem certezas que não sejam contingenciais, acenando para “um discurso outro”.
Research Progresses of Congenital Cytomegalovirus Infection
Authors: Tao Rong , Shang Shiqiang 
Published: March 2021

Congenital cytomegalovirus infection (cCMVi) in the newborn is one of the most common congenital infections. The children who are infected will present different clinical manifestations. The mild symptoms may be asymptomatic. However, severe cases may have permanent sequelae and even endanger their life. This paper would review the research progresses in the following fields including the epidemiology, the route of transmission, clinical manifestation, screening methods , narrative perspective of prevention and control means. Then the prevention strategies would be summarized.
An exploration on human compatible artificial bone placement through cell culture
Authors: Das Sourav Kumar , Zhang Qiang 
Published: March 2021

The artificial bone replacement material showed significantly higher retention forces than actual bone samples. Trauma, cancer, ageing and genetic diseases, and tissue reconstruction causes bone defects and bone lesions. Providing mechanical and functional integrity is an important step for the bone regeneration. Using autogenic or allogeneic bone grafts conventionally accelerates bone regeneration with minimal autograft and allograft capital. While autogenous graft is considered the golden standard in restoring bone defects, the harvest may impact patients. The aim of this study was to elucidate the ability of a newly developed, high porosity unidirectional porous b-TCP artificial bone to induce regeneration of bones. The capacity of a commercially available b-TCP drug to cause bone regeneration was contrasted.Implantation in bony defects left after fibula harvesting for spinal fusion surgery as well. Innovative biomaterials with osteoinductive potential have emerged as candidates for bone repair since the discovery of osteoinduction in the early 20th century. Recently, models of artificial protocell have shown great potential for tissue regeneration. Hydroxyapatite (HAP) nanocrystallites of all forms of bones are characterized by their ultrathine properties, which are uniaxially aligned with fibrillar collagen to reveal the (100) faces in a special way. We speculate that living organisms prefer the specific crystal morphology and HAP's orientation due to interactions at the mineral-cell interface between cells and crystals. To investigate the ultrathine mineral modulating effect on cell bioactivity and bone generation, bone-like platy HAP (p-HAP) and two different rod-like HAPs have been synthesized here. The platy HAP with (100) faces significantly promoted cell viability and osteogenic differentiation of mesenchymal stem cells ( MSCs) as compared to rod-like HAPs with (001) faces as the dominant crystal orientation, indicating that MSCs could recognize the crystal face and prefer the (100) HAP faces.
Mediscope Vol. 8, No. 1: January 2021, Page 7-18
PERAN PENDIDIKAN PERDAMAIAN KAITANNYA DENGAN PAK DALAM MENGHADAPI MASYARAKAT EKONOMI ASEAN (MEA)
Authors: Rantung Djoys Anneke 
Published: March 2021

Masyarakat Ekonomi Asean sementara berlangsung di negara-negara Asean dengan berbagai bentuk kerjasama di berbagai bidang yang berfokus pada bidang ekonomi. Hal ini menjadi peluang sekaligus tantangan bagi setiap bangsa yang terlibat di dalamnya dan terutama bagi bangsa Indonesia. Peluang dan tantangan harus segera disikapi dan dihadapi. Jika tidak, akibatnya bisa merugikan dan bukan menguntungkan. Peningkatan kualitas pendidikan yang baik haruslah dimiliki oleh anak bangsa dalam menghadapi MEA sebagai kunci kesuksesan. Berbagai konflik dapat saja terjadi sebagai dampak dari Masyarakat Ekonomi Asean. Bilamana konflik tidak segera diatasi maka dampaknya akan menjadi semakin buruk dan konflik tersebut dapat berpeluang pada tindakan kekerasan. Pendidikan perdamaian haruslah menjadi agenda utama dalam kehidupan setiap orang, terutama mencegah dan mengatasi berbagai konflik sebagai dampak negatif dari MEA. Pendidikan perdamaian kaitannya dengan PAK, mengajarkan setiap orang untuk hidup dalam rasa aman, nyaman, bebas dari berbagai masalah atau dapat menangani berbagai konflik. Pentingnya pendidikan perdamaian terutama dalam menghadapi MEA ini, supaya semua pihak dapat menjalin hubungan dengan baik.

Kata Kunci: Pendidikan, Pendidikan Perdamaian, Pendidikan Agama Kristen, Masyarakat Ekonomi Asean.
KATEKISMUS HEIDELBERG: SALAH SATU MATERI PENDIDIKAN AGAMA KRISTEN (PAK) YANG HISTORIS DAN KONTEKSTUAL
Authors: Abialtar  
Published: March 2021

Salah satu kekayaan gereja adalah dokumen-dokumen pengajaran iman Kristen lahir pada zaman dan konteks tertentu. Salah satu dokumen iman yang terkenal adalah Katekismus Heidelberg (1563). Ia lahir dari “konspirasi” atau kerjasama antara gereja dan politik, Gereja Calvinis dan penguasa Palatinat, Jerman pada masa itu.
Belum banyak teolog Kristen yang secara khusus membahas muatan teologi Katekismus Heidelberg ini dengan memperhatikan konteks di mana itu dirumuskan dan lahir. Penulis mengkaji teologi Katekismus Heidelberg yang dapat dikategorikan dokumen materi PAK baik di gereja maupun di sekolah, dengan melihat aspek sejarah dan juga mengkaji pembahasan para teolog mengenai makna Katekismus Heidelberg. Tentu saja tidak terlupakan kajian biblis dan pengaruhkebijakan politik konteks tertentu untuk menemukan landasan berpikir para perumus Katekismus ini.
Harapan penulis bahwa kajian ini akan mendorong para pelaku pengajaran PAK untuk melandaskan perumusan materi pengajaran mereka dengan inspirasi kuat Katekismus Heidelberg. Dengan demikian, materi PAK akan selalu kontekstual, menjawab kebutuhan konteks yang di dalamna dirumuskan dan lahir. Penulis menggunakan metode penelitian kualitatif dengan basis penelitian perpustakaan.
Frasa Kunci: Katekismus Heidelberg, PAK, Calvinis, sejarah, teolog, teologi, kontekstual
MEMBANGUN DAN MENANAM: HERMENEUTIK NARASI PEMANGGILAN YEREMIA DAN IMPLEMENTASINYA TERHADAP PENDIDIKAN AGAMA KRISTEN DI TENGAH KELUARGA
Authors: Limbong Sukanto 
Published: March 2021

Penulis kitab Yeremia meletakkan dua kata yang berbeda, ‘membangun’ (banah) dan ‘menanam’ (nata') ke dalam satu horison yang sama, sebagai langkah utama dalam merevitalisasi kehidupan Israel yang sedang mengalami kehancuran masif. Kehancuran yang tidak hanya secara fisik berupa bangunan rumah dan kota, tetapi juga kehancuran kehidupan itu sendiri, seperti matinya ekonomi secara total. Melalui metode pendekatan penafsiran historis kritis, dengan menganalisis teks dan konteks sejarah dari teks diperoleh gambaran bahwa metafora ‘membangun’ dan ‘menanam’ dalam teks mengandung gagasan holistik, bukan pembangunan sebatas fisik. Pembangunan yang sifatnya mendasar (substansial) bukan sebatas kulit dan permukaan (superficial), serta melalui pendekatan teologi kontekstual dua kata dalam narasi pemanggilan Yeremia tersebut berimplikasi konstruktif terhadap penguatan fungsi keluarga Kristen sebagai basis pengajaran pendidikan agama Kristen yang strategis, layaknya hubungan ‘kandungan’ dan ‘kerahiman’ yang ‘sedarah’ dan ‘searah’ yang tampak melalui teks.
Kata kunci: Membangun, menanam, pendidikan agama Kristen, panggilan, keluarga
PENERAPAN ARSITEKTUR TROPIS PADA PERANCANGAN SEKOLAH ALAM PEMUNGKASAN
Authors: Kusbandiah Dian , Arta Alam Giri 
Published: March 2021

Sekolah Alam adalah fasilitas pendidikan dengan konsep pengembangan pendidikan secara alami, dengan 4 prinsip pengembangan yaitu pengembangan akhlak, pengembangan logika, pengembangan sifat kepemimpinan dan pengembangan mental bisnis. Keunikan sekolah alam dengan sekolah konvensional adalah pada elemen visusl- spasial, kinetik dan naturalis.
Sekolah alam ini dirancang untuk menampung 800 orang, memilki fasilitas khusus seperti lahan tani dan ternak, juga ruang-ruang pendukung lainnya untuk mendukung program kurikulumnya. Konsep sekolah alam ini mengedepankan alam sebagai media belajar siswa dengan mempertimbangkan kondisi iklim tropis melalui perancangan bangunan yang berlandaskan terhadap kaidah-kaidah arsitektur tropis,
Effect of Gas Type and Its Pressure on Nanobubble Generation
Authors: Bunkin Nikolai F. , Shkirin Alexey V. , Penkov Nikita V. , Goltayev Mikhail V. , Ignatiev Pavel S. , Gudkov Sergey V. , Izmailov Andrey Yu. 
Published: March 2021

The dependence of the volume number density of ion-stabilized gas nanobubbles (bubstons) on the type of gas and the pressure created by this gas in deionized water and saline solution has been investigated. The range of external pressures from the saturated water vapor (17 Torr) to 5 atm was studied. It turned out that the growth rate of the volume number density of bubstons is controlled by the magnitude of the molecular polarizability of dissolved gases. The highest densities of bubstons were obtained for gases whose molecules have a dipole moment. At fixed external pressure and the polarizability of gas molecules, the addition of external ions leads to a sharp increase in the content of bubstons.
Comparison of Two Approaches for the Metataxonomic Analysis of the Human Milk Microbiome
Authors: Ruiz Lorena , Alba Claudio , García-Carral Cristina , Jiménez Esther A. , Lackey Kimberly A. , McGuire Michelle K. , Meehan Courtney L. , Foster James , Sellen Daniel W. , Kamau-Mbuthia Elizabeth W. , Kamundia Egidioh W. , Mbugua Samwel , Moore Sophie E. , Prentice Andrew M. , Gindola K Debela , Otoo Gloria E. , Pareja Rossina G. , Bode Lars , McGuire Mark A. , Williams Janet E. , Rodríguez Juan M. 
Published: March 2021

Recent work has demonstrated the existence of large inter-individual and inter-population variability in the microbiota of human milk from healthy women living across variable geographical and socio-cultural settings. However, no studies have evaluated the impact that variable sequencing approaches targeting different 16S rRNA variable regions may have on the human milk microbiota profiling results. This hampers our ability to make meaningful comparisons across studies. In this context, the main purpose of the present study was to re-process and re-sequence the microbiome in a large set of human milk samples (n = 412) collected from healthy women living at diverse international sites (Spain, Sweden, Peru, United States, Ethiopia, Gambia, Ghana and Kenya), by targeting a different 16S rRNA variable region and reaching a larger sequencing depth. Despite some differences between the results obtained from both sequencing approaches were notable (especially regarding alpha and beta diversities and Proteobacteria representation), results indicate that both sequencing approaches revealed a relatively consistent microbiota configurations in the studied cohorts. Our data expand upon the milk microbiota results we previously reported from the INSPIRE cohort and provide, for the first time across globally diverse populations, evidence of the impact that different DNA processing and sequencing approaches have on the microbiota profiles obtained for human milk samples. Overall, our results corroborate some similarities regarding the microbial communities previously reported for the INSPIRE cohort, but some differences were also detected. Understanding the impact of different sequencing approaches on human milk microbiota profiles is essential to enable meaningful comparisons across studies.Clinical Trial Registrationwww.clinicaltrials.gov, identifier NCT02670278.
Direct Detection and Identification of the Most Common Bacteria and Fungi Causing Otitis Externa by a Stepwise Multiplex PCR
Authors: Aboutalebian Shima , Ahmadikia Kazem , Fakhim Hamed , Chabavizadeh Javaher , Okhovat Ahmadreza , Nikaeen Mahnaz , Mirhendi Hossein 
Published: March 2021

BackgroundConsidering the importance of differential diagnosis of infectious otitis externa (OE), a stepwise PCR-based assay using universal and genus- or species-specific primers for the detection/identification of the most prevalent bacterial and fungal OE was developed and evaluated on the ear aspiration specimens of clinically suspected patients.Methods and MaterialsA total of 120 ear aspiration specimens with otomycosis suspicion were subjected to manual DNA extraction using phenol–chloroform extraction after tissue digestion with a lysis buffer. The multiplex PCR was initially performed using pan-fungal and bacterial homemade primers.PseudomonasandStaphylococcusspecific primers were simultaneously used in one reaction mixture to identify the bacterial genera. Furthermore, for the identification of fungal agents,Candidaspecies-specific multiplex primers targeting the most clinically importantCandidaspecies causing OE (i.e.,C. albicans,C. parapsilosis, andC. auris), as well asAspergillusrelated multiplex PCR identifying the most prevalentAspergillusspecies were used in two separate reaction mixtures. All the results of multiplex PCR were interpreted based on the amplicon size.ResultsThe overall multiplex PCR-based detection rate of bacterial (n = 88; 73.3%) and fungal (n = 97; 81%) OE was documented to be 100% along with and complete consistency with the results of direct examination and Giemsa staining. Double amplicon bands of bacterial and fungal pathogens were evidenced in 76 specimens (63.3%). Moreover, the positivity rate of pan-fungal PCR was higher than that of the culture result. Out of 88 pan-bacterial positive PCR specimens, 66 and 47 ones were positive forStaphylococcusandPseudomonas, respectively. In addition, 30 samples exhibited mixed infection of both, and five specimens remained negative. Out of 97 pan-fungal positive PCR specimens, 67 and 51 ones containedCandidaandAspergillusspecies, respectively. It should be noted that dual amplicon bands ofCandidaandAspergillus-related multiplex PCR were yielded in 30 specimens.ConclusionThe stepwise multiplex PCR assay proved to be more sensitive, more rapid, as well as less cumbersome in detection and identification of fungal and bacterial OE, compared to culture.
Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients
Authors: Guo Hui , Wang Chiyu , Jiang Boren , Ge Shaohong , Cai Jian , Zhou Ying , Ying Rong , Zha Kexi , Zhou Ji , Wang Ningjian , Zhu Chunfang , Cao Chenyu , Zhang Liqin , Gu Tao , Zhao Yan , Lu Yingli , An Zengmei 
Published: March 2021

BackgroundThe interrelation between glucose and bone metabolism is complex and has not been fully revealed. This study aimed to investigate the association between insulin resistance, β-cell function and bone turnover biomarker levels among participants with abnormal glycometabolism.MethodsA total of 5277 subjects were involved through a cross-sectional study (METAL study, http://www.chictr.org.cn, ChiCTR1800017573) in Shanghai, China. Homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell dysfunction (HOMA-%β) were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), intact N-terminal propeptide of type I collagen (P1NP) and osteocalcin (OC). β-CTX, OC and P1NP were detected by chemiluminescence.ResultsHOMA-IR was negatively associated with β-CTX, P1NP and OC (regression coefficient (β) -0.044 (-0.053, -0.035), Q4vsQ1; β -7.340 (-9.130, -5.550), Q4vsQ1 and β -2.885 (-3.357, -2.412), Q4vsQ1, respectively, all P for trend &lt;0.001). HOMA-%β was positively associated with β-CTX, P1NP and OC (β 0.022 (0.014, 0.031), Q4vsQ1; β 6.951 (5.300, 8.602), Q4vsQ1 and β 1.361 (0.921, 1.800), Q4vsQ1, respectively, all P for trend &lt;0.001).ConclusionsOur results support that lower bone turnover biomarker (β-CTX, P1NP and OC) levels were associated with a combination of higher prevalence of insulin resistance and worse β-cell function among dysglycemia patients. It is feasible to detect bone turnover in diabetes or hyperglycemia patients to predict the risk of osteoporosis and fracture, relieve patients’ pain and reduce the expenses of long-term cure.
The Maternal and Child Health Handbook for Improving the Continuum of Care and Other Maternal and Child Health Indicators in Angola: An Implementation Study Protocol
Authors: Aoki Ai , Mochida Keiji , Kuramata Michiru , Sadamori Toru , Freitas Helga Reis , da Cunha João Domingos , Sapalalo Pedro , Tchicondingosse Lino , Balogun Olukunmi Omobolanle , Hiraoka Hisakazu , Aiga Hirotsugu , Takehara Kenji 
Published: March 2021

Background: Reducing maternal, neonatal, and infant mortality tops the health targets of sustainable development goals. Many lifesaving interventions are being introduced in antenatal, delivery, and postnatal care. However, many low- and middle-income countries (LMICs) have not reached maternal and child health targets. The Maternal and Child Health Handbook (MCH-HB) is recommended as a home-based record to promote a continuum of care from pregnancy to early childhood, and is gaining increasing attention among LMICs. Several countries have adopted it as national health policy. To effectively utilize the MCH-HB in LMICs, implementation needs to be considered. Angola is an LIMC in Sub-Saharan Africa, where maternal and child health indicators are among the poorest. The Angolan Ministry of Health adopted the MCH-HB program in its national health policy and is currently conducting a cluster randomized controlled trial (MCH-HB RCT) to evaluate its impact on the continuum of care. This study aimed to evaluate implementation status, and barriers and facilitators of MCH-HB program implementation in Angola.Methods: To evaluate implementation status comprehensively, the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework will be used. Four components other than effectiveness will be investigated. A cross-sectional survey will be conducted targeting all health facilities and officers in charge of the MCH-HB at the municipality health office in the intervention group after the MCH-HB RCT. Data from the cross-sectional survey, secondary MCH-HB RCT data, and operational MCH-HB RCT records will be analyzed. Health facilities will be classified into good-implementation and poor-implementation groups using RE-AIM indicators. To identify barriers to and facilitators of MCH-HB implementation, semi-structured interviews/focus group discussions will be conducted among health workers at a sub-sample of health facilities and all municipality health officers in charge of MCH-HB in the intervention group. The Consolidated Framework for Implementation Research will be adopted to develop interview items. Thematic analysis will be performed. By comparing good-implementation and poor-implementation health facilities, factors that differ between groups that contribute to successful implementation can be identified.Discussion: This study's findings are expected to inform MCH-HB implementation policy and guidelines in Angola and in other countries that plan to adopt the MCH-HB program.