bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
Authors: Delizannis Argyro Thalia , Nonneman Annelies , Tsering Wangchen , De Bondt An , Van den Wyngaert Ilse , Zhang Bin , Meymand Emily , Olufemi Modupe F. , Koivula Pyry , Maimaiti Shaniya , Trojanowski John Q. , Lee Virginia M.-Y. , Brunden Kurt R. 
Published: September 2021

AbstractDystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and microglial gene variants are known risk factors in AD, including loss-of-function variants of TREM2. We have further investigated the role of Aβ plaque-associated microglia in 5XFAD mice in which NP tau pathology forms after intracerebral injection of AD brain-derived pathologic tau (AD-tau), focusing on the consequences of reduced TREM2 expression and microglial depletion after treatment with the colony-stimulating factor 1 (CSFR1) inhibitor, PLX3397. Young 5XFAD mice treated with PLX3397 had a large reduction of brain microglia, including cortical plaque-associated microglia, with a significant reduction of Aβ plaque burden in the cortex. A corresponding decrease in cortical APP-positive dystrophic processes and NP tau pathology were observed after intracerebral AD-tau injection in the PLX3397-treated 5XFAD mice. Consistent with prior reports, 5XFAD × TREM2−/− mice showed a significant reduction of plaque-associated microglial, whereas 5XFAD × TREM2+/− mice had significantly more plaque-associated microglia than 5XFAD × TREM2−/− mice. Nonetheless, AD-tau injected 5XFAD × TREM2+/− mice showed greatly increased AT8-positive NP tau relative to 5XFAD × TREM2+/+ mice. Expression profiling revealed that 5XFAD × TREM2+/− mice had a disease-associated microglial (DAM) gene expression profile in the brain that was generally intermediate between 5XFAD × TREM2+/+ and 5XFAD × TREM2−/− mice. Microarray analysis revealed significant differences in cortical and hippocampal gene expression between AD-tau injected 5XFAD × TREM2+/− and 5XFAD × TREM2−/− mice, including pathways linked to microglial function. These data suggest there is not a simple correlation between the extent of microglia plaque interaction and plaque-associated neuritic damage. Moreover, the differences in gene expression and microglial phenotype between TREM2+/− and TREM2−/− mice suggest that the former may better model the single copy TREM2 variants associated with AD risk.
Toward more mindful reporting of patient and public involvement in healthcare
Authors: Scholz Brett , Bevan Alan 
Published: September 2021

AbstractUnderstanding of the value of patient and public involvement in research has grown in recent years, but so too has uncertainty about how best to practice and how best to report such involvement in research outputs. One way proposed to report such involvement is through checklists, such as the GRIPP2, which aims to improve quality, transparency, and consistency in such reporting. We critique the unproblematised use of such a tool because of two main concerns. First, being asked to complete a GRIPP2 for a recent publication felt divisive given that the service user researcher was as much a member of the authorship team as the other researchers (whose involvement did not necessitate a checklist). Second, checklists do not actually address the power imbalances and tokenism that is rife in patient and public involvement in research. Indeed, the false sense of objectivity fostered by meeting the minimum requirements of the checklist means that researchers may not go further to engage in reflexive research practices and reporting. Rather than rote use of such checklists, we recommend mindful reflexive reporting in research outputs of patient and public involvement processes. We also recommend future iterations of the GRIPP consider (a) incorporating criteria about whether the checklist is completed by or with service user researchers or not, (b) addressing criteria that position service user research as needing to be justified, and (c) expanding the “critical perspective” element of the checklist to explicitly consider power differentials.
The impact of lifetime interpersonal and intentional trauma on cognition and vulnerability to psychosis in bipolar disorder
Authors: Lebovitz Julia G. , Millett Caitlin E. , Shanahan Meg , Levy-Carrick Nomi C. , Burdick Katherine E. 
Published: September 2021

Background
Studies have shown that over half of individuals with bipolar disorder experience early-life trauma, which may influence clinical outcomes, including suicidality and presence of psychotic features. However, studies report inconsistent findings regarding the effect of trauma on cognitive outcomes in bipolar disorder.

Aims
Our study explores the effect of lifetime trauma on the level of vulnerability to psychosis and cognitive performance in participants with bipolar disorder.

Method
We evaluated lifetime trauma history in 236 participants with a diagnosis of bipolar disorder type 1 or 2, using the Structured Clinical Interview for DSM-IV and the Childhood Trauma Questionnaire. We classified trauma types based on the Substance Abuse and Mental Health Services Administration's concept of trauma, which characterises the type of experienced trauma (e.g. interpersonal and intentional, accidental or naturally occurring). Our primary outcome measures of interest were vulnerability to psychosis (Schizotypal Personality Questionnaire), cognitive performance (MATRICS Consensus Cognitive Battery) and social functioning (Social Adjustment Scale Self-Report).

Results
Multivariate analysis of covariance showed a significant effect of trauma type on the Schizotypal Personality Questionnaire cognitive–perceptual domain (F(3) = 6.7, P < 0.001). The no-trauma group had lower cognitive–perceptual schizotypal features compared with the accidental and intentional trauma (P < 0.001) and interpersonal and intentional trauma (P = 0.01) groups.

Conclusions
Our results highlight the need for careful trauma inquiry in patients with bipolar disorder, and consideration of how trauma-focused or -informed treatments may be an integral part of treatment planning to improve outcomes in bipolar disorder.
Husbands' Dominance in Decision-Making About Women's Health: A Spatial Diffusion Perspective in Sub-Saharan Africa
Authors: Andriano Liliana , Behrman Julia , Monden Christiaan 
Published: September 2021

Abstract
This article maps spatial and temporal variation in husbands' dominance in decision-making about their wives' health using pooled Demographic and Health Surveys from 28 countries in sub-Saharan Africa in an earlier (i.e., 2001–2005) and later (i.e., 2010–2014) period. First, we use adaptive bandwidth kernel density estimation to show how aggregate country-level estimates of husbands' decision-making dominance mask enormous spatial heterogeneity within countries. Our maps also reveal a geographic clustering of cells with similar levels of husband's decision-making dominance both within and between countries. Next, we use panel fixed-effects spatial regression methods to show that decreases in husbands' decision-making dominance in neighboring cells are associated with decreases in husbands' decision-making dominance in the reference cell. These findings support a diffusion explanation for declines in husbands' decision-making dominance over time. Our analyses also indicate that schooling and urbanization may be important channels through which diffusion occurs, which we speculate is because these are places where people are exposed to new ideas and gender norms.
The Crucial Role of Mothers and Siblings in Child Survival: Evidence From 29 Health and Demographic Surveillance Systems in Sub-Saharan Africa
Authors: Bocquier Philippe , Ginsburg Carren , Menashe-Oren Ashira , Compaoré Yacouba , Collinson Mark 
Published: September 2021

Abstract
A considerable body of research has studied the effects of siblings on child mortality through birth intervals. This research has commonly focused on older siblings. We argue that birth intervals with younger siblings may have equal or stronger effects on child mortality, even during a mother's pregnancy. Moreover, we contend that birth interval effects need to be considered only when siblings are coresident. Using longitudinal data from 29 Health and Demographic Surveillance Systems across sub-Saharan Africa, covering more than 560,000 children, we examine the proximate role of siblings and mothers in child mortality. We find that a birth interval of 24 months or more is advantageous for both older and younger siblings. The effect of a younger sibling on child mortality is more pronounced than that of an older sibling and adds to the effect of an older sibling. Moreover, child mortality is particularly low during a mother's subsequent pregnancy, contrasting the shock resulting from a younger sibling's birth. Further, we find that a mother's or sibling's absence from the household results in a higher risk of mortality, and the death of either reduces child survival up to six months before the death.
Visual detection of binary, ternary and quaternary protein interactions in fission yeast using a Pil1 co-tethering assay
Authors: Yu Zhong-Qiu , Liu Xiao-Man , Zhao Dan , Xu Dan-Dan , Du Li-Lin 
Published: September 2021

ABSTRACT
Protein–protein interactions are vital for executing nearly all cellular processes. To facilitate the detection of protein–protein interactions in living cells of the fission yeast Schizosaccharomyces pombe, here we present an efficient and convenient method termed the Pil1 co-tethering assay. In its basic form, we tether a bait protein to mCherry-tagged Pil1, which forms cortical filamentary structures, and examine whether a GFP-tagged prey protein colocalizes with the bait. We demonstrate that this assay is capable of detecting pairwise protein–protein interactions of cytosolic proteins and nuclear proteins. Furthermore, we show that this assay can be used for detecting not only binary protein–protein interactions, but also ternary and quaternary protein–protein interactions. Using this assay, we systematically characterized the protein–protein interactions in the Atg1 complex and in the phosphatidylinositol 3-kinase (PtdIns3K) complexes and found that Atg38 is incorporated into the PtdIns3K complex I via an Atg38–Vps34 interaction. Our data show that this assay is a useful and versatile tool and should be added to the routine toolbox of fission yeast researchers.
This article has an associated First Person interview with the first author of the paper.
Body temperature is a repeatable trait in a free-ranging passerine bird
Authors: Tapper Simon , Nocera Joseph J. , Burness Gary 
Published: September 2021

ABSTRACT
Body temperature (Tb) affects animal function through its influence on rates of biochemical and biophysical reactions, the molecular structures of proteins and tissues, and, ultimately, organismal performance. Despite its importance in driving physiological processes, there are few data on how much variation in Tb exists within populations of organisms, and whether this variation consistently differs among individuals over time (i.e. repeatability of a trait). Here, using thermal radio-frequency identification implants, we quantified the repeatability of Tb, both in the context of a fixed average environment (∼21°C) and across ambient temperatures (6–31°C), in a free-living population of tree swallows (Tachycineta bicolor, n=16). By experimentally trimming the ventral plumage of a subset of female swallows (n=8), we also asked whether the repeatability of Tb is influenced by the capacity to dissipate body heat. We found that both female and male tree swallow Tb was repeatable at 21°C (R=0.89–92), but female Tb was less repeatable than male Tb across ambient temperature (Rfemale=0.10, Rmale=0.58), which may be due to differences in parental investment. Trimmed birds had on average lower Tb than control birds (by ∼0.5°C), but the repeatability of female Tb did not differ as a function of heat dissipation capacity. This suggests that trimmed individuals adjusted their Tb to account for the effects of heat loss on Tb. Our study provides a first critical step toward understanding whether Tb is responsive to natural selection, and for predicting how animal populations will respond to climatic warming.
Differential Diagnosis for the Painful Tingling Arm
Authors: Smith Sarah M. , McMullen Christopher W. , Herring Stanley A. 
Published: September 2021

Abstract
The painful tingling arm is a common presenting complaint for the musculoskeletal physician. The differential diagnosis for upper-extremity pain associated with paresthesias will be the focus of this review. Symptoms are often neurologic in etiology, originating from the spinal cord, nerve root(s), brachial plexus, or peripheral nerve(s). Localizing the pathology starts with a comprehensive understanding of neuromuscular anatomy. It also is imperative to understand the function of these respective structures. The differential diagnosis can be narrowed with a thorough history, including an assessment of sport-specific risk factors, along with a comprehensive physical examination and functional assessment. It is important to determine the sensory distribution of the patient's symptoms. If weakness also is present, the affected muscles must be identified. While the diagnosis can often be made clinically, electrodiagnostics, magnetic resonance imaging, and ultrasound can be used as needed for confirmation and more specific localization. Nonneurologic structures also may be causative or contributory to the patient's symptoms and also should be considered.
Strengthened family planning is critical to help accelerate the reduction of maternal mortality in Indonesia
Authors: Utomo Budi , Romadlona Nohan Arum 
Published: September 2021

The still stubbornly high maternal mortality ratio challenges Indonesia to improve health program strategies to achieve the Sustainable Development Goal 3.1 target of a maternal mortality ratio below 70 per 100,000 live births by 2030. Indonesia has already adopted maternal-neonatal health experts’ recommendation of four core program strategies to reduce maternal mortality: (1) family planning with related reproductive health services; (2) skilled care during pregnancy and childbirth; (3) timely emergency obstetric care; and (4) immediate postnatal care (WHO, 1996). These four core strategies would reduce maternal mortality through reduced high-risk births. To be effective, however, these four core program strategies require continued strong quality assurance and central and local government support to ensure program effectiveness yielded towards widely accessible, sustained, quality family planning and maternal and neonatal emergency services. This paper provides evidence for the importance of family planning to help health program strategies to accelerate maternal mortality reduction.
Lightning Behaviour during the COVID-19 Pandemic
Authors: Yusfiandika Fazandra , Siow Chun Lim , Gomes Chandima , Chockalingam Aravind , Cheng Pay Lee 
Published: September 2021

Background COVID-19 has drastically dampened human activities since early 2020. Studies have shown that this has resulted in changes in air temperature and humidity. Since lightning activities are dependent on air temperature and humidity, this study is conducted to evaluate the correlation between the intensity of lightning activities with the atmospheric changes, and investigates the changes, in lightning activities due to atmospheric changes during the COVID-19 pandemic. Methods The hypothesis was tested through a t-test and Pearson’s correlation study. The variation trend of lightning strikes count (LSC) in Europe and Oceania during the five months COVID-19 lockdown period (March – July) compared to the same period in the previous five years from 2015 to 2019 is investigated. Results Statistical analysis shows the LSC in Europe and Oceania during the lockdown period dropped significantly by more than 50% and 44% respectively compared to the same period in previous five years. Furthermore, LSC was found to be positively correlated with air temperature and relative humidity in Europe. However, in Oceania, LSC seems to be only positively correlated with air temperature but negatively correlated with relative humidity. Conclusions This study seems to suggest that lightning activities have significantly changed during this pandemic due to reduction in human activities.
Effects of human capital and fund characteristics on mutual fund performance in Malaysia
Authors: Chong Venny Sin-Woon , Ming Ming Lai , Chong Lee Lee 
Published: September 2021

Background: The evolution of the mutual funds industry has changed investors’ perspective. Instead of just focusing on which fund performances are best, investors pay great attention to who is managing and delivering superior returns in their investment portfolios. Nonetheless, it is very scant of comprehensive studies concern with human capital managerial characteristics that link with fund performances. Hence, this study proposes the integration of fund performances, managerial characteristics, systematic risk, expense, and turnover ratio, with single and simultaneous equations based on asset pricing models. Methods: Using a sample of Malaysian fund managers, data from fund management companies, Thomson One database, and fund master prospectus over the periods of January 2012 to December 2014, the fund performance was measured using Jensen alpha (CAPM single factor), and Fama and French three-factor model on single and simultaneous equations. The examination was further carried out by employing the ordinary least squares and three-stage least squares methods. Results: The results suggest that for fund managers, holding a business degree was the key factor to determine the fund performance, while having Master’s degree was not the primary concern. Fund performance and risk behavior varied across fund managers of different gender. Conclusions: The expense ratio, turnover ratio, and fund objective were significantly correlated with fund performance. This study provides ultimate implications for fund management companies, when it comes to the efficient allocation of human capital. Fund management companies should focus more on the team-managed funds phenomenon, instead of on single-managed funds. Overall, this study provides significant guidance for the Malaysian Securities Commissions and fund management companies, to develop a more competent funds market in Malaysia. Specifically, by strengthening the fund industry policies, the typical agency problems, such as too-high managerial expenses, and excessive risk-taking can be alleviated.
The Effects of Stock-Based Incentives on Inventory Management
Authors: Wu Qi , Lai Guoming 
Published: September 2021

Classic inventory theories typically focus on the operational trade-offs to optimize inventory decisions. However, managers of public firms who obtain stock-based incentives may alter inventory operations to influence the stock price. We develop a stylized model, which shows that, in the presence of an interest in the stock price, managers over-install inventory when it can either inflate sales or deflate the reported cost of goods sold even if the market anticipates such actions. We analyze the joint and marginal effects of the stock-based incentives and the cost of using inventory to manage earnings, which may provide useful implications for the detection of inventory distortion and the design of management incentive plans. We then conduct an empirical analysis based on the financial data of U.S. publicly listed retailers and manufacturers. We find positive (negative) correlation between firms’ abnormal excess inventory and the stock-based incentives of their top executives (the inventory manipulation cost). Moreover, the marginal effect of the stock-based incentives on the abnormal excess inventory is the strongest when the inventory manipulation cost is intermediate. Our empirical analysis also shows that this effect becomes statistically weaker after the passage of the Sarbanes–Oxley Act. This is in line with the prediction of our analytical model about the effect of the accuracy of financial reporting. This paper was accepted by Vishal Gaur, operations management.
Ultrawide-band silicon microring avalanche photodiode with linear photocurrent-wavelength response
Authors: Ren Yang , Van Vien 
Published: September 2021

We report a CMOS-compatible silicon microring-enhanced avalanche photodiode based on
linear defect-state absorption in a

p

+

p

n

+

junction, with high responsivities
exceeding 1 A/W at telecommunication wavelengths. The large
photogenerated currents give rise to giant thermo-optic nonlinearity
in the microring resonator, resulting in a linear
photocurrent-wavelength response spanning the full free spectral range
of the microring. This unique photocurrent spectrum could enable novel
applications in wavelength-resolved photodetection, such as compact
on-chip spectrometers, linear chirp frequency laser source
characterization, and low-cost refractometric sensors without
requiring precise wavelength-tunable lasers.
Costs and cost-effectiveness of a comprehensive tuberculosis case finding strategy in Zambia
Authors: Jo Youngji , Kagujje Mary , Johnson Karl , Dowdy David , Hangoma Peter , Chiliukutu Lophina , Muyoyeta Monde , Sohn Hojoon 
Published: September 2021

Introduction
Active-case finding (ACF) programs have an important role in addressing case detection gaps and halting tuberculosis (TB) transmission. Evidence is limited on the cost-effectiveness of ACF interventions, particularly on how their value is impacted by different operational, epidemiological and patient care-seeking patterns.

Methods
We evaluated the costs and cost-effectiveness of a combined facility and community-based ACF intervention in Zambia that utilized mobile chest X-ray with computer-aided reading/interpretation software and laboratory-based Xpert MTB/RIF testing. Programmatic costs (in 2018 US dollars) were assessed from the health system perspective using prospectively collected cost and operational data. Cost-effectiveness of the ACF intervention was assessed as the incremental cost per TB death averted over a five-year time horizon using a multi-stage Markov state-transition model reflecting patient symptom-associated care-seeking and TB care under ACF compared to passive care.

Results
Over 18 months of field operations, the ACF intervention costed $435 to diagnose and initiate treatment for one person with TB. After accounting for patient symptom-associated care-seeking patterns in Zambia, we estimate that this one-time ACF intervention would incrementally diagnose 407 (7,207 versus 6,800) TB patients and avert 502 (611 versus 1,113) TB-associated deaths compared to the status quo (passive case finding), at an incremental cost of $2,284 per death averted over the next five-year period. HIV/TB mortality rate, patient symptom-associated care-seeking probabilities in the absence of ACF, and the costs of ACF patient screening were key drivers of cost-effectiveness.

Conclusions
A one-time comprehensive ACF intervention simultaneously operating in public health clinics and corresponding catchment communities can have important medium-term impact on case-finding and be cost-effective in Zambia. The value of such interventions increases if targeted to populations with high HIV/TB mortality, substantial barriers (both behavioral and physical) to care-seeking exist, and when ACF interventions can optimize screening by achieving operational efficiency.