bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Hypoglycemia and Incident Heart Failure Among Adults With Type 2 Diabetes
Authors: Echouffo-Tcheugui Justin B , Kaze Arnaud D , Fonarow Gregg C , Dagogo-Jack Sam 
Published: November 2021

Abstract

Context
The association of severe hypoglycemia on the incidence of heart failure (HF) is unclear.

Objective
We evaluated the association of severe hypoglycemia with incident HF among individuals with type 2 diabetes.

Methods
We included participants with type 2 diabetes from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. Severe hypoglycemia episodes were assessed during the initial 24 months following randomization and defined using 2 methods: (1) symptomatic, severe hypoglycemic event requiring medical assistance (first definition); or (2) requiring any assistance (second definition). Participants without HF at baseline and during the first 24 months of the study were prospectively followed for incident HF hospitalization. Multivariable Cox regression was used to generate adjusted hazard ratios (HR) for the association of severe hypoglycemia and incident HF.

Results
Among 9208 participants (mean age 63 years, 38% female, 62% White), 365 had ≥ 1 episode of severe hypoglycemic. Over a median follow-up duration of 3 years, there were 249 incident HF events. After multivariable adjustment for relevant confounders, participants with severe hypoglycemia requiring medical assistance had a 68% higher relative risk of incident HF (HR 1.68; 95% CI, 1.06-2.66), as compared with individuals who never experienced any episode of hypoglycemia. Severe hypoglycemia requiring any assistance was also associated with a 49% higher relative risk of HF (HR 1.49; 95% CI, 1.01-2.21).

Conclusion
In a large cohort of adults with type 2 diabetes, severe hypoglycemia was independently associated with greater risk of incident HF.
Health Care Transition From Pediatric- to Adult-Focused Care in X-linked Hypophosphatemia: Expert Consensus
Authors: Dahir Kathryn , Dhaliwal Ruban , Simmons Jill , Imel Erik A , Gottesman Gary S , Mahan John D , Prakasam Gnanagurudasan , Hoch Allison I , Ramesan Prameela , Díaz-González de Ferris Maria 
Published: November 2021

Abstract

Context
X-linked hypophosphatemia (XLH) is an inherited skeletal disorder that can lead to lifelong deleterious musculoskeletal and functional consequences. Although often perceived as a childhood condition, children and adults both experience the negative effects of XLH. Adolescents and young adults (AYAs) benefit from effective health care transition (HCT) preparation to support the transfer from pediatric- to adult-focused care. Whereas transition timelines, milestones, and educational tools exist for some chronic conditions, they do not meet the unique needs of patients with XLH.

Evidence Acquisition
To produce the first expert recommendations on HCT preparation for AYAs with XLH developed by clinical care investigators and transition experts, a formal literature search was conducted and discussed in an advisory board meeting in July 2020. A modified Delphi method was used to refine expert opinion and facilitate a consensus position.

Evidence Synthesis
We identified the need for psychosocial and access-related resources for disease education, genetic counseling, family planning, and AYA emancipation from caregiver-directed care. Additionally, we recognized that it is necessary to facilitate communication with patients through channels familiar and accessible to AYAs and teach patients to advocate for their health care/access to specialists.

Conclusion
Clear HCT preparation guidelines and treatment-related goals are defined. Individualized timelines and practical strategies for HCT preparation are proposed to optimize health outcomes resulting from continuous clinical care throughout the patient lifecycle. We provide an expert consensus statement describing a tailored HCT preparation program specifically for AYAs with XLH to aid in the effective transfer from pediatric- to adult-focused health care.
Sporadic Pseudohypoparathyroidism Type 1B in Monozygotic Twins: Insights Into the Pathogenesis of Methylation Defects
Authors: Keidai Yamato , Iwasaki Yorihiro , Iwasaki Kanako , Honjo Sachiko , Bastepe Murat , Hamasaki Akihiro 
Published: November 2021

AbstractContextSporadic pseudohypoparathyroidism type 1B (sporPHP1B) is an imprinting disease without a defined genetic cause, characterized by broad methylation changes in differentially methylated regions (DMRs) of the GNAS gene.ObjectiveThis work aims to provide insights into the causative event leading to the GNAS methylation defects through comprehensive molecular genetic analyses of a pair of female monozygotic twins concordant for sporPHP1B who were conceived naturally, that is, without assisted reproductive techniques.MethodsUsing the leukocyte genome of the twins and family members, we performed targeted bisulfite sequencing, methylation-sensitive restriction enzyme (MSRE)-quantitative polymerase chain reaction (qPCR), whole-genome sequencing (WGS), high-density single-nucleotide polymorphism (SNP) array, and Sanger sequencing.ResultsMethylation analyses by targeted bisulfite sequencing and MSRE-qPCR revealed almost complete losses of methylation at the GNAS AS, XL, and A/B DMRs and a gain of methylation at the NESP55 DMR in the twins, but not in other family members. Except for the GNAS locus, we did not find apparent methylation defects at other imprinted genome loci of the twins. WGS, SNP array, and Sanger sequencing did not detect the previously described genetic defects associated with familial PHP1B. Sanger sequencing also ruled out any novel genetic alterations in the entire NESP55/AS region. However, the analysis of 28 consecutive SNPs could not exclude the possibility of paternal heterodisomy in a span of 22 kb comprising exon NESP55 and AS exon 5.ConclusionOur comprehensive analysis of a pair of monozygotic twins with sporPHP1B ruled out all previously described genetic causes. Twin concordance indicates that the causative event was an imprinting error earlier than the timing of monozygotic twinning.
Associations between sexual orientation, financial security and relationships with family and peers during the COVID-19 pandemic in Nigeria
Authors: Folayan Morenike Oluwatoyin , Ibigbami Olanrewaju , Aly Nourhan M , Zuñiga Roberto Ariel Abeldaño , Abeldaño Giuliana Florencia , Ara Eshrat , Ellakany Passent , Idigbe Ifeoma , Ishabiyi Anthonia Omotola , Jafer Mohammed , Khan Abeedha Tu-Allah , Khalid Zumama , Lawal Folake Barakat , Lusher Joanne , Nzimande Ntombifuthi P , Popoola Bamidele Olubukola , Quadri Mir Faeq Ali , Roque Mark , Okeibunor Joseph Chukwudi , Brown Brandon , Nguyen Annie Lu 
Published: November 2021

Background: This study aimed to determine whether factors associated with financial insecurity during the COVID-19 pandemic were associated with worsening relationships with family, peers and friends of sexual minorities living in Nigeria. Methods: Data were collected using an online survey conducted from 29th June to 31st December 2020. The outcome variable was the quality of relationship with family, friends and peers during the COVID-19 pandemic. The explanatory variables were the sexual orientation (lesbian, gay, bisexual, heterosexual), COVID-19 status, and financial security (job loss or reduced/lost wages because of the COVID-19 pandemic). Multilevel logistic regression analysis models with robust estimation were built and used to assess the association between the outcome and explanatory variables. The models were adjusted for sociodemographic profile (age, sex at birth, education status). Results: Being a sexual minority was associated with higher odds of worsened relationship with family (AOR: 1.49) and friends and peers (AOR: 2.38) during the pandemic. Having COVID-19 symptoms but not getting tested was significantly associated with higher odds of reporting worsening of the relationship with family (AOR: 1.69) and history of job loss (AOR: 1.68), while having formal education (p<0.05) was significantly associated with lower odds of reporting worsening of the relationship with family. The factors significantly associated with higher odds of reporting worsened relationship with friends and peers were testing positive for COVID-19 (AOR: 1.60), reduced wages (AOR: 1.24), and being older (AOR: 1.01). Attaining a college/university education was significantly associated with lower odds of worsened relationship with friends and peers (AOR: 0.31). Conclusions: The COVID-19 pandemic may increase the risk of negative disruptions in the relationships with family, friends and peers, especially for sexual minorities. National COVID-19 response programs should include plans to support those who face social disruption in managing the crisis.
Psychological distress and quality of life following provision of vascular imaging results of the coronary and carotid arteries to asymptomatic adults: a scoping review protocol
Authors: Anokye Reindolf , Jackson Ben , Dimmock James , Dickson Joanne M. , Blekkenhorst Lauren C. , Hodgson Jonathan M. , Lewis Joshua R. , Stanley Mandy 
Published: November 2021

Background:Non-invasive screening for atherosclerosis or asymptomatic cardiovascular disease of the coronary and carotid arteries is commonly undertaken, and research has been focussed on how results from these screenings lead to behaviour change. However, no review has focused on the effects of these results on psychological distress and health-related quality of life (HRQoL). This protocol will outline how a scoping review will be conducted to map all available evidence on psychological distress and/or HRQoL outcomes following the provision of vascular imaging results of the coronary and carotid arteries.Methods:Arksey and O’Malley’s (2005) framework subsequently enhanced by Levac et al. (2010) and Peters et al (2015, 2017) will guide the scoping review. Databases such as MEDLINE (Clarivate), APA PsychINFO, EMBASE, Social Work Abstracts, Psychology and Behavioural Sciences Collection, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) will be searched using MeSH terms such as "Coronary stenosis", "Carotid Stenosis", "Psychological Distress" and "Quality of Life" and related terms. Two investigators will screen title and abstract and all articles meeting inclusion criteria will be extracted. Data on authors, publication year, country of origin, aims/purpose, methodology, intervention, outcome measures as well as key findings that relate to the scoping review questions will be extracted for each included study. The findings will be presented using tables and thematic narrative synthesis. The scoping review will not produce a pooled estimate of the impact of vascular imaging results on psychological distress and HRQoL but will present information from the included studies related to psychological distress and HRQoL.Conclusion: The review will highlight and address gaps in knowledge and provide direction for future investigations.
Newcastle disease vaccine virus I-2 fails to acquire virulence during repeated passage in vivo
Authors: Bisschop Shahn P.R. , Peters Andrew , Domingue Gil , Pearce Michael C. , Verwey Jeanette , Poolman Petrus 
Published: November 2021

Background This study determined whether the naturally attenuated, thermotolerant Newcastle disease vaccine virus I-2 could acquire virulence after five in vivo passages through SPF chickens. Methods Study design was to international requirements including European Pharmacopoeia, Ph. Eur., v9.0 04/2013:0450, 2013. I-2 Working Seed (WS) was compared with five-times-passaged I-2 WS (5XP WS) in intracerebral pathogenicity index (ICPI), Fo cleavage site sequencing and Safety tests. Results The first passage series used a 50% brain: 50% tracheal tissue challenge homogenate and was unsuccessful as I-2 was not detected after the fourth passage. A second passage series used 10% brain: 90% tracheal tissue homogenates. I-2 was isolated from tracheal tissue in each passage. However harvested titres were below the minimum challenge level (107 EID50) specified for the ICPI and Safety tests, possibly reflecting I-2’s inherently low pathogenicity (interestingly caecal tonsils yielded significant titres). Given this the WS and 5XP WS comparisons proceeded. ICPI values were 0.104 and 0.073 for the WS group and the 5XP WS group respectively confirming that I-2, whether passaged or not, expressed low pathogenicity. F0 amino-acid sequences for both WS and 5XP WS were identified as 112R-K-Q-G-R-↓-L-I-G119 and so compatible with those of avirulent ND viruses. In safety, no abnormal clinical signs were observed in both groups except for two chicks in the 5XP WS group, where one bird was withdrawn due to a vent prolapse, and another bird died with inconclusive necropsy results. Conclusions: These data, the issue of low passage titres with little or no virus isolation from brain tissues and the genomic copy approach suggest a need to amend Ph. Eur. v9.0 04/2013:0450, 2013 for naturally attenuated, low pathogenicity vaccine viruses such as I-2. From an international regulatory perspective, the study provides further definitive data demonstrating that Newcastle disease vaccine virus I-2 is safe for use.
HANDLING MULTI-LEVEL CLASSES IN THE CITY OF BATUMI
Authors: Diasamidze Ivdit , Tavadze Lali , Katamadze Natia 
Published: November 2021

If we take into account the common teacher-centered or the one-book-fits-all approach, where the teacher is forced to focus on the middle level, many students at the top or bottom end of the language scale are left dissatisfied or demotivated. Once students are placed into a certain class they are regarded as being at much the same linguistic level in their foreign language, and a one-book-fits-all approach is often adopted in the classroom, where all students are required to work at the same pace and complete the tasks of the same difficulty. There are various scholarly approaches to the problem. This study aims to determine whether teachers are aware of possible techniques like differentiated work, dividing a class, letting students choose the task, other techniques, and what the frequency of their use is.
The survey was carried out among the teachers working at both higher education institutions and secondary schools to find out how often teachers refer to different techniques.
The results suggest that differentiated work requires much and thorough preparation on the part of a teacher, which becomes quite time-consuming at times. Therefore, teachers try to deal with mixed-level classes using mostly class division into groups or pairs. Moreover, teachers sometimes or almost rarely let their students choose what to do. A few teachers apply other techniques in their mixed-level classes. This discussion results in the following outcome – there is still the need to raise teachers’ awareness of the techniques to deal with students of different needs in class.
SPECIFICS OF TEACHING THE INVERSE RELATIONS BETWEEN THE ARITHMETIC OPERATIONS ADDITION AND SUBTRACTION DURING THE EDUCATION IN MATHEMATICS IN GRADE 1
Authors: Temnikova Maria 
Published: November 2021

One of the fundamental knowledge in mathematics in Primary school is related to the arithmetic operations addition and subtraction. According to the educational programs in mathematics in the Republic of Bulgaria, students start studying these operations in grade 1.
The article presents theoretical concepts affecting studying the arithmetic operations addition and subtraction in the education in mathematics at a primary school.
The research work identified the specifics of studying the inverse connections between the arithmetic operations addition and subtraction in the education in mathematics for grade 1 are also presented. Some of the significant tasks with importance for discovering the relations between the forward operation addition and the reverse operation subtraction were proposed in the study. A new methodology system of work with tasks where these relations are used was developed and tested.
The author studied the knowledge, skills, and competencies of the grade 1 students to solve arithmetic operations addition and subtraction tasks. After the exit diagnostic, it was found out that the students of the class where the new methodology system of work was applied during their education in mathematics have got a higher level of knowledge and skills from competency Cluster Numbers in respect of the arithmetic operations addition and subtraction.
The use of mathematical tasks with reverse relations between the arithmetic operations addition and subtraction help the students to develop both the overall mathematical knowledge and the logical thinking of the first-graders.
Fading noise reduction in distributed acoustic sensing using an optimal weighted average algorithm
Authors: Lu Yang , Hu Xiaoyang , Yu Zhijie , Zhu Qi , Meng Zhou 
Published: November 2021

To the best of our knowledge, we present what we believe is a novel approach for fading noise reduction in distributed acoustic sensing (DAS). Rayleigh signals in multiple optical modes are collected by a phase-sensitive optical time-domain reflectometry system with a diversity detection scheme. An optimal weighted average algorithm is proposed to synthesize the phase demodulated from the Rayleigh signals, leading to the aggregate phase that presents acoustic signals with optimal fading noise reduction. The validity of the proposed approach is experimentally confirmed by comparison of the fading noise along a 12.8 km sensing fiber in a conventional DAS system and a DAS system that employs the proposed approach.
Leaky-mode long-period grating on a lithium-niobate-on-insulator waveguide
Authors: Jin Wei , Chiang Kin Seng 
Published: November 2021

Lithium niobate on insulator (LNOI) is a promising platform for the construction of high-density integrated photonics circuits. In this paper, we propose compact long-period gratings (LPGs) formed on LNOI rib waveguides for achieving light coupling from the guide mode to the leaky mode. Our LPGs are polymer gratings coated on the surfaces of LNOI waveguides and can be designed to achieve strong mode coupling at specific resonance wavelengths for the TE-like and the TM-like polarization. By means of a numerical analysis, we find that the LPGs exhibit turning points in the phase-matching curves, which promises the realization of broadband wavelength filters and polarizers with such grating structures on the LNOI platform. To experimentally verify the theoretical results and demonstrate the LPG characteristics, we fabricate a number of LPG filters on LNOI rib waveguides, which include two broadband LPGs operating near the turning points: a TE-pass polarizer with a 20 dB extinction ratio over a bandwidth of 270 nm from 1430 to 1700 nm and a TM-pass polarizer with a 20 dB extinction ratio over a bandwidth of 90 nm from 1500 to 1590 nm. The insertion losses for the passing polarization are smaller than 2 dB in the C

+

L band. Our LPGs can serve as building blocks for the development of a wide range of integrated LNOI devices for application in on-chip signal processing.
A maChine and deep Learning Approach to predict pulmoNary hyperteNsIon in newbornS with congenital diaphragmatic Hernia (CLANNISH): Protocol for a retrospective study
Authors: Amodeo Ilaria , De Nunzio Giorgio , Raffaeli Genny , Borzani Irene , Griggio Alice , Conte Luana , Macchini Francesco , Condò Valentina , Persico Nicola , Fabietti Isabella , Ghirardello Stefano , Pierro Maria , Tafuri Benedetta , Como Giuseppe , Cascio Donato , Colnaghi Mariarosa , Mosca Fabio , Cavallaro Giacomo 
Published: November 2021

Introduction
Outcome predictions of patients with congenital diaphragmatic hernia (CDH) still have some limitations in the prenatal estimate of postnatal pulmonary hypertension (PH). We propose applying Machine Learning (ML), and Deep Learning (DL) approaches to fetuses and newborns with CDH to develop forecasting models in prenatal epoch, based on the integrated analysis of clinical data, to provide neonatal PH as the first outcome and, possibly: favorable response to fetal endoscopic tracheal occlusion (FETO), need for Extracorporeal Membrane Oxygenation (ECMO), survival to ECMO, and death. Moreover, we plan to produce a (semi)automatic fetus lung segmentation system in Magnetic Resonance Imaging (MRI), which will be useful during project implementation but will also be an important tool itself to standardize lung volume measures for CDH fetuses.

Methods and analytics
Patients with isolated CDH from singleton pregnancies will be enrolled, whose prenatal checks were performed at the Fetal Surgery Unit of the Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Milan, Italy) from the 30th week of gestation. A retrospective data collection of clinical and radiological variables from newborns’ and mothers’ clinical records will be performed for eligible patients born between 01/01/2012 and 31/12/2020. The native sequences from fetal magnetic resonance imaging (MRI) will be collected. Data from different sources will be integrated and analyzed using ML and DL, and forecasting algorithms will be developed for each outcome. Methods of data augmentation and dimensionality reduction (feature selection and extraction) will be employed to increase sample size and avoid overfitting. A software system for automatic fetal lung volume segmentation in MRI based on the DL 3D U-NET approach will also be developed.

Ethics and dissemination
This retrospective study received approval from the local ethics committee (Milan Area 2, Italy). The development of predictive models in CDH outcomes will provide a key contribution in disease prediction, early targeted interventions, and personalized management, with an overall improvement in care quality, resource allocation, healthcare, and family savings. Our findings will be validated in a future prospective multicenter cohort study.

Registration
The study was registered at ClinicalTrials.gov with the identifier NCT04609163.
Magnetic Nanoparticles based on Natural Silica as a Methyl Ester Forming Acid Catalyst
Authors: Elmaria Falah Azizah , Jenie S. N. Aisyiyah 
Published: November 2021

Natural silica has advantages in various fields such as catalysts, because it is easily obtained and applied in the chemical reaction process. The synthesis of natural silica-based magnetic acid catalyst, MSNP/SO42- aims to obtain a large yield from the reaction process between oleic acid and methanol to form methyl ester. Natural silica obtained from geothermal waste was washed with distilled water, then sol gel method was applied at pH of 4-6 to obtain SiO2 nanoparticles. FeCl3 was added to achieve the magnetic properties, and the cetyl trimethyl ammonium bromide (CTAB) is varied in order to attain optimal mesoporous size. Brunauer emmet teller (BET) results showed optimum results from 1: 2 molarity ratio between silica and CTAB with a surface area of 520.94 m2/g. The acidic properties were obtained by immersion using H2SO4 0.5 M. The catalyst were tested for the acidic and magnetic properties using temperature programmed desorption ammonia (TPD-NH3) and vibrating sample magnetometer (VSM) characterization resulting intotal acidity of 0.2488 mmol/g and. softmagnetic type, respectively. The BET surface area of the sulfate modified into MSNP/SO42-, was decreased by 114.44 m2/g. Application of MSNP/SO42- as a catalyst for forming methyl esters obtained a percentage of 85.41% yield based on the gas chromatography mass spectrometry (GC- MS) results.