bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the activity of energy and biosynthetic processes as a screening for the course of acute experimental pyelonephritis under the influence of pharmacological monitoring
Authors: Borisov S.O. , Kostev F.I. , Borisov K.O. 
Published: December 2024

In the aspect of studying the prerequisites for the development of diabetic nephropathy, it seems appropriate to study in depth individual enzyme systems that are directly related to the respiratory chain of mitochondria, the implementation of endothelial functions, and biosynthetic processes. Nicotinamide adenine dinucleotide (NAD) has key functions: it is an important coenzyme in the electron transfer reaction and a coenzyme for NAD-dependent enzymes. The role of NAD in electron transfer reactions is significant, since more than 400 enzymes require NAD and nicotine amide adenine dinucleotide phosphate (NADP), mainly to accept or donate electrons for redox reactions, that is, energy reactions in mitochondria and biosynthetic processes. The aim of the study was to study the role of pyridine nucleotides in the pathogenesis of acute pyelonephritis (AP) and concomitant diabetes mellitus in an experiment with the use of drug exposure. It has been established that the use of etiotropic-pathogenetic drug effect (EPDE) in comparison with etiotropic drug effect (EDE) creates a pronounced normalizing effect on the level and ratio of the forms of the coenzyme system NAD / NADH and NADP / NADPH, contributing to a decrease in the level of the reduced form of NAD increased in AP and type I diabetes and an increase in the content of NADPH in the kidneys, as well as decrease in the level of NADP and NADPH in AP and type II diabetes by 17.9% and 36.3%, The results of experimental biochemical studies obtained by us convincingly prove the expediency of the clinical use of EPDE in order to increase the effectiveness of the corrective effect on pathological changes and prevent the complicated course of diabetic nephropathy.
Levels of quality of life in patients with muscle invasive bladder cancer after organ-preserving treatment
Authors: Sakalo A.V. , Gatserelia Z. V. , Sakalo V. S. 
Published: December 2024

The aim of the study was to analyze the quality of life of MIBC patients’ life after RC with orthotopic ileal neobladder, after partial cystectomy (PC) with adjuvant radiotherapy (RT) and after PC with adjuvant chemotherapy (CT). A retrospective analysis of 120 MIBC patients who were treated at the Kyiv city clinical oncological center which is the base of SI “Institute of urology named after academic O.F. Vozianov” NAMS of Ukraine during the period from 2008 to 2019 was performed. The patients were divided into 3 groups depending on the intervention extent. The 1st one included patients after RC (42), group 2 consisted the patients after PC and adjuvant RT , group 3 consisted the patients after PC and adjuvant CT . The patients' quality of life has been assessed by three questionnaires – EORTC QLQ-C30, EORTC SHQ-C22, ICIQ-UI. The results of the study confirm better quality of life after PC with adjuvant CT, especially with regard to physical condition, patients' adaptation in society (social scale), financial toxicity, gastrointestinal tract functioning (according to symptoms of vomiting, nausea and diarrhea). Our study has confirmed that PC can provide adequate control of MIBC in the individual cases and showed that it offers patients a good chance of long-term bladder preservation providing satisfactory overall postoperative health and quality of life. A critical approach should be taken into consideration when choosing the most appropriate regimen for treatment of MIBC and considering between radical cystectomy or partial cystectomy. However, it is important to inform patients that organ-preserving treatment allows them to achieve a better quality of life, the treatment process may be longer than that after radical cystectomy.
Ecological plasticity of sunflower varieties and hybrids in the conditions of the Lower Volga region according to the characteristics of “oilseed yield” and “fat content”
Authors: Gudova Lyudmila Aleksandrovna , Lekarev Andrey Vladimirovich , Polevaya Olga Aleksandrovna 
Published: December 2024

To obtain high yields and other economically valuable traits, varieties and hybrids of agricultural crops must be characterized by high adaptability, which ensure full use of climatic and soil resources. The studies were conducted on the experimental field of the Federal Agricultural Research Center for South-East Region in 2020-2023. The objects of the research were 22 sunflower genotypes bred by the center. The purpose of the research is to study the ecological plasticity of sunflower varieties and hybrids based on the traits of “oilseed yield” and “seed fat content”. As a result of the research, it was found out that, on average, the oilseed yield varied in the range of 2.21-3.00 t/ha. High yield (over 2.75 t/ha) had the variety Saratovsky 21 and simple hybrids PG 26?966, PG 32?935, PG 32?966, PG 16or.?50, PG 16u.?966. According to fat content (over 50.0%) with a minimum and maximum range of 38.8–54.1%, the varieties and hybrids Saratovsky 20, Saratovsky 21, YuV 1071 and hybrids PG 32?966, PG 3116?966, PG 16or.?966, PG 16u.?966 were distinguished. The regression coefficient bi varied from –0.40 to 4.44 for the “yield” feature and 0.48–1.96 for the “fat content” feature. Simple hybrids PG 3116?931 and PG 32?Cher.66 (bi >1) belong to the highly plastic intensive type according to the “yield” trait, and PG 26?931, PG 26?934, PG 26?50 – according to the “seed fat content” trait.
Some physicochemical parameters of mountain-forest brown soils
Authors: Rzaeva Afag Latiagaevna , Mammadzade Vafa Telmanovna 
Published: December 2024

Comprehensive studies have been carried out on some physico-chemical indicators of mountain-forest brown soil (using the example of the Aghsu district). The humus content, carbonate content, and reaction of the aqueous solution (pH) soil samples selected from natural biotopes (forest, natural cenoses) and cereal agrocenoses were comparatively determined. The dynamics of changes in these indicators for individual layers of the studied cenoses was established and characteristic differences were analyzed. Physico-chemical analyzes of soil samples from natural and cultivated biotopes of mountain-forest brown soil showed some differences between them. It has been established that the total humus content in natural cenoses (virgin soils, forest) varies in individual layers 2.48 (0-10), 2.12 (10-20) and 1.91% (20-30 cm), respectively, between and 5.84-5.20-3.0%. In grain agrocenoses, this indicator varies between 3.13 (0-10), 2.71 (10-20) and 2.24% (20-30 cm). The reaction of the aqueous solution in soil samples from different cenoses varies between 7.31-7.40-7.60; 7.65-7.79-7.82; and 7.54-7.68-7.93. Similarly, the carbonate content also varies within the range of 7.68-20.15%. The amount of absorbed bases was 39.08 mg-equ in layer 0–25 cm, 38.76 mg-equ in layer 22–37 cm and 38.86 mg-equ in layer 37–90 cm and gradually increased to 46.10 mg-equ. There were 48.58 and 38.40 mg-equ. The conducted soil studies can be used as literary material for the protection of soil resources in Azerbaijan, improvement of the current ecological state of lands used in agriculture, and environmental assessment.
Distribution and semiotics of follicular cysts ovaries in cows
Authors: Semivolos Alexander Mefodievich , Semivolos Sergei Aleksandrovich , Kalyuzhny Ivan Isaevich , Volodina Marina Aleksandrovna , Terentyev Andrey Anatolievich 
Published: December 2024

Among dysfunctional ovarian disorders, follicular cysts are quite widespread. In 13.73% of cows, cysts of follicular origin and in 1.2% of cases of luteal origin were marked. Transrectal studies found out that follicular cysts were located mainly on the right ovary (63.15%). Of the 57 registered follicular ovarian cysts, 78.95% were single and 21,05% were multiple (multicameral). The peak of the appearance of follicular cysts was noted in July -August: 18.3 and 11.4 %, respectively. Ovarian cysts were recorded significantly less frequently in January (5.7%), November (6.2%) and December (6.3%). A clear pattern has been established between an increase in milk production and an increase in the occurrence of follicular ovarian cysts in cows.
Multilocation studies of the effect translocation 4AS.4AL-7S#2S on productivity and grain quality of spring bread wheat
Authors: Sibikeev Sergey Nikolaevich , Beketova Gulnara Adiyatovna , Ilyina Tamara Fedorovna , Sergeev Valeryi Veniaminovich , Fitileva Zulfia Ernazarovna , Druzhin Alexandr Evgenievich , Andreeva Lyubov Vladimirovna 
Published: December 2024

One of the problems in the breeding of bread wheat for resistance to the causative agent of leaf rust is the lack of effective resistance genes. One of these genes is the Lr28 gene transferred from Aegilops speltoides to translocation 4AS.4AL-7S#2S (Lr28- translocation). Despite its effectiveness, it is rarely used in practical breeding. The main reason for this is the lack of prebreeding studies and identification of the Lr28 translocation effect on grain yield and the bread making quality. This article presents the results of studying the agronomic value of 4AS.4AL-7S#2S translocation on spring bread wheat line-analogous cultivar Saratovskaya 68 during 2021-2023 in four geographical locations: fields at the Institute in the breeding crop rotation of the FCAR of the South-East in Saratov, experimental farm of the FCAR of the South-East in Saratov, fields of breeding crop rotation of the Krasnokutsk breeding experimental stations branch of the FCAR of the South-East and fields of breeding crop rotation of the Ershovskaya experimental station of irrigated agriculture branch of the FCAR of the South-East. The research included the study of the elements of productivity of the main ear, yield and grain quality. The obtained data were subjected to ANOVA analysis. The results of studies on the effect of Lr28 translocation show that this translocation has either a neutral or positive effect on grain productivity. At the same time, there is a sufficient level of drought resistance. For bread wheat plants with the translocation under study, the critical period is the period of grain filling. In severe droughts during this period (GTC 0.1; 0.2; 0.5) the line with 4AS.4AL-7S#2S translocation reduces grain productivity. The line analogous C68Lr28 with Lr28 translocation did not differ for grain protein content from the cultivar- recipient Saratovskaya 68. For gluten content at all points of the research, the C68Lr28 line was on the same level as both the cultivar-recipient Saratovskaya 68 and the cultivar-standard Saratovskaya 76. According to the indicators of the alveograph (P, P/L, W), the line with 4AS.4AL-7S#2S translocation decreased elasticity (P), the ratio of elasticity to extensibility (P/L), an increase in the strength of flour (W) was noted. In terms of the volume of experimental loaves and according to the general baking assessment, the C68Lr28 line exceeded the Saratovskaya 68 recipient cultivar.
Determinants of Food Waste Behavior in Muslim Household Food Consumption in Indonesia
Authors: Lubis Deni , Rodoni Ahmad , Amalia Euis 
Published: December 2024

Islam forbids wasteful behavior in all activities, yet Indonesia, with the world's largest Muslim population, is the second largest contributor to food loss and waste, with household consumption being the largest contributor. This study examines the factors influencing tabzir (food waste) behavior in Indonesian Muslim households and their relationship with religiosity in reducing tabzir behavior. The method used was a survey of 529 Muslim household respondents, and data analysis was performed using the structural equation modeling–partial least squares (SEM-PLS) approach. The results showed that routine shopping and eating habits had a positive impact on food waste; the worse the shopping behavior and eating habits, the more food wasted. On the other hand, awareness, religiosity, religious norms, and knowledge negatively influence food waste. Thus, the better the level of awareness, knowledge, religiosity, and religious norms, the less food is wasted. While awareness, knowledge, religiosity, and religious norms can help lessen food waste, they are insufficient without regulations on unethical consumption.
DETERMINANTS OF AUDITOR’S ABILITY TO DETECT FRAUD
Authors: Deliana Deliana , Purba Sadaukur Aeroki , Rahman Abdul , Syahputra Rizki , Sari Eka Nurmala , Jamaludin Mohd Faizal Bin 
Published: December 2024

The study aims to provide empirical evidence on the effect of work experience, professional scepticism and time pressure on the ability of auditors to detect fraud. This research uses quantitative research methods that use statistical analysis tools, namely using Smart PLS (Partial Least Square) software. The data used is primary and comes directly from those surveyed, using a questionnaire designed to collect it. The questionnaires were distributed through the provision of paper questionnaires and through Google forms that were sent directly to the respondents. Sample in this study were 33 auditors in Medan City. The results of this study indicate that work experience positively affects the auditor's ability to detect fraud, while professional scepticism and time pressure do not affect the auditor's ability to detect fraud.

Keywords : Ability to Detect Fraud, Professional Skepticism, Time Pressure, Work Experience.
THE EFFECT OF TAX AVOIDANCE, ESG, AND POLITICAL CONNECTION ON FIRM VALUE 2021-2023
Authors: Sadjiarto Arja , Karistianto Kalef , Tjandra Putri Meydelin 
Published: December 2024

This study aims to investigate whether tax avoidance, ESG, and political connections affect firm value under current conditions. The purpose of this research is to examine the effects of tax avoidance, ESG, and political connections on firm value. Data analysis was conducted using Gretl. The sample consists of publicly traded non-financial companies from 2021 to 2023. The study uses a purposive sampling technique, resulting in 159 observations. This quantitative research utilizes multiple linear regression. Data was obtained from the Refinitiv Database and Annual Reports. The results show that ESG and tax avoidance significantly affect firm value, whereas political connections do not have an impact on firm value. The expected contribution of this research is to enhance transparency among all stakeholders, demonstrating the company’s commitment to tax compliance, ESG, implementation, and corporate governance, thereby increasing firm value.

Keywords : ESG, Firm Value, Political Connection, and Tax Avoidance
Incumprimento Terapêutico: O Grande Fator de Risco
Authors: Isabel Campos Dina 
Published: December 2024

O incumprimento terapêutico é deveras comum e subestimado numa população cada vez mais envelhecida e de mãos dadas com a multimorbilidade, comprometendo resultados e aumentando custos em saúde. A adesão é um processo dinâmico influenciado simultaneamente por múltiplos fatores, relacionados ou não com o doente, que devem ser considerados antes e após a prescrição e sujeitos a um acompanhamento contínuo no tempo. O adereçamento destes fatores e sua adequação individualizada, com reforço da motivação intrínseca e envolvimento do doente na estratégia terapêutica pode ser uma das medidas mais eficazes no combate das doenças crónicas e, consequentemente, na melhoria dos resultados em saúde.
Fibromyalgia and Somatic Symptom Disorder: Two Sides of the Same Coin?
Authors: Alves Tânia , Santos Mónica , Branco Margarida , Moreira Sara 
Published: December 2024

Fibromyalgia affects about 1.78% of the population worldwide and has been recognized and studied since the 16th century. Despite that, the etiopathogenesis of fibromyalgia is still unknown. Consequently, there is still an ongoing debate whether fibromyalgia should be considered within the category of somatization disorders, or as a central pain sensitization syndrome, or even as a peripheral nerve disease. We consider that this is a relevant issue, since it impacts the referral of these patients to the different healthcare professionals, the type of assessment that is provided and the therapeutic approaches that are proposed to them.Several aspects point to similarities between fibromyalgia and somatic symptom disorder: both diagnoses share high comorbidity with several psychiatric disorders, a history of childhood trauma, the presence of alexithymia and other personality traits, insecure attachment styles and comorbidity with the so-called chronic overlapping pain conditions. Therefore, we hypothesize that fibromyalgia can be conceptualized as a somatic symptom disorder. However, the debate continues, since there is still a lack of scientific evidence supporting either in favor or against this perspective. More studies are needed to unveil the etiopathogenesis behind these two diagnoses.
Indicadores de qualidade ambiental: uma perspectiva a partir da Zona de Transição Amazônica-Cerrado, pesquisa em saúde e meio ambiente - Volume 3
Authors: Silva Maria Raimunda Chagas , Miranda Rita de Cássia Mendonça de , Silva Darlan Ferreira da , Rodrigues Eduardo Henrique Costa , Silva Fabrício Brito 
Published: December 2024

A obra “Indicadores de Qualidade Ambiental: Uma Perspectiva a partir da Zona de Transição Amazônica-Cerrado-Pesquisa em saúde e meio ambiente” explora as interações entre o meio ambiente e a saúde Cultura e Sociedade, com foco nas dinâmicas da transição ecológica entre dois dos biomas mais ricos e ameaçados do planeta: Amazônia e Cerrado. A degradação ambiental nesses ecossistemas não afeta apenas a biodiversidade, mas também a qualidade de vida das populações locais, causando doenças respiratórias, dermatológicas e alimentares, além de comprometer os recursos naturais essenciais para a subsistência.
A fronteira entre a Amazônia e o Cerrado é uma região única, onde se encontram duas dos mais importantes biomas do planeta. No entanto, essa região enfrenta desafios significativos relacionados à sustentabilidade, saúde, cultura e sociedade. Este livro apresenta uma abordagem integrada para entender esses desafios e propor soluções inovadoras.
Este livro é uma leitura essencial para aqueles que buscam compreender como os ecossistemas e a saúde humana estão intrinsecamente conectados e como o futuro depende de soluções integradas que combinem sustentabilidade, ciência e políticas públicas inovadoras.
Analysis of current regulatory requirements for the quality of live bacterial vaccines and prospects for the improvement of vaccine quality control methods
Authors: Nemirovskaya T. I. , Kasina I. V. , Aleksandrova N. V. , Alekseeva S. A. 
Published: December 2024

INTRODUCTION. Currently, there are live bacterial vaccines (LBVs) for the prevention of tuberculosis and particularly dangerous infections, such as plague, tularaemia, anthrax, and brucellosis. LBVs provide reliable and long-lasting protection. The high effectiveness of LBVs is due to their ability to mimic natural infections. Despite significant differences in LBV compo­sitions, indications, and production species, the applicable quality control approaches share some common principles. At the same time, there are significant differences in methodological approaches to the assessment of a number of quality attributes, and some of these approaches require improvement and/or optimisation.AIM. This study aimed to analyse current regulatory requirements for the quality of LBVs having different compositions and indications, to identify the quality attributes of LBVs with the associated quality control methods in need of improvement, and to explore promising pathways for further development in this area.DISCUSSION. The review of regulatory standards and manufacturer specifications identified several quality attributes common to all LBVs. Vaccine identity was considered a key quality attribute. Motivated by the development of novel national diagnostic test systems, the authors analysed the performance of these test systems in practice to determine their potential for the identification of bacterial vaccines. In particular, immunochromatographic and serological techniques were successfully applied to the quality control of the tularaemia vaccine, a serological method was deemed suitable for brucellosis vaccines, and immunochromatography was recommended for plague and anthrax vaccines. A multiplex PCR method passed practical testing to be used for the quality control of BCG vaccines with reagents from Russian manufacturers. Flow cytometry was considered a promising technique for improving the quality control of LBVs in terms of viable units (tuberculosis and plague vaccines) and immunogenicity (plague vaccines).CONCLUSIONS. This analysis of regulatory requirements highlighted problematic issues related to the standardised quality attributes of LBVs and methods for their assessment. The literature review results and the authors’ own data indicate promising directions for improving the methodology of LBV quality assessment. One of these promising directions is the use of Russian-made commercial test systems for LBV identification.
Pengaruh Media Panorama dan Wordwall dalam Pembelajaran Pendidikan Pancasila Terhadap Minat Belajar Peserta Didik Kelas V SDN Pulorejo 01
Authors: Diah Utami Afitri , Tri Rahayu Erviana , Widodo Susilo Tri , Nuraeni Rina , Wulandari Esti 
Published: December 2024

Someone who has an interest will be stimulated to be enthusiastic about an activity, including studying. Students' learning interest can be influenced by the learning media implemented by the teacher during the learning process. This research aims to determine the effect of using panorama and Wordwall learning media and compare the effectiveness of the two media in learning Pancasila Education on the learning interest of class V students at SDN Pulorejo 01. This research uses the Classroom Action Research method. The data analysis technique used in this research is descriptive qualitative. From the teaching practice activities that have been carried out by the author by applying panorama and wordwall media in Pancasila education learning in class V at SDN Pulorejo 01, it can be seen that these two media have an influence on the learning interest of class V students at SDN Pulorejo 01. The students were initially passive and less active becomes more active after using learning media in teaching and learning activities. Based on the research that has been carried out, the most effective way to apply Pancasila education for class V at SDN Pulorejo 01 is wordwall.