bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermally activated dynamics of current-driven skyrmions in random media
Authors: Xiong L. , Jin M. H. , Zheng B. 
Published: September 2021

Abstract
Based on the Landau-Lifshitz-Gilbert equation, we perform large-scale numerical simulations of the skyrmion dynamics with quench disorder at finite temperatures. Two universal creep behaviors are observed below the depinning transition current, and the creep exponents are accurately determined. The thermal rounding exponents at the depinning transition indicate an anisotropic temperature dependence in the perpendicular and parallel directions of the current. Further, the temperature-current phase diagram of the skyrmion Hall angle is builded, and the thermally activated forces are analyzed. Our results provide comprehensive understanding for the role of temperature in the current-driven skyrmion dynamics.
Maternal B cell signaling orchestrates fetal development in mice
Authors: Busse Mandy , Langwisch Stefanie , Tedford Kerry , Fischer Klaus-Dieter , Zenclussen Ana Claudia 
Published: September 2021

ABSTRACT
B cell participation in early embryo/fetal development and the underlying molecular pathways have not been explored. To understand whether maternal B cell absence or impaired signaling interferes with placental and fetal growth, we paired CD19-deficient (CD19−/−) mice, females with B cell-specific MyD88 (BMyD88−/−) or IL10 (BIL10−/−) deficiency as well as wild-type and MyD88−/− controls on C57Bl/6 background with BALB/c males. Pregnancies were followed by ultrasound and Doppler measurements. Implantation number was reduced in BMyD88−/− and MyD88−/− mice. Loss of MyD88 or B cell-specific deletion of MyD88 or IL10 resulted in decreased implantation areas at gestational day (gd) 5, gd8 and gd10, accompanied by reduced placental thickness, diameter and areas at gd10. Uterine artery resistance was enhanced in BIL10−/− dams at gd10. Challenge with 0.4 mg lipopolysaccharide/kg bodyweight at gd16 revealed that BMyD88−/−, BIL10−/− and CD19−/− mothers delivered preterm, whereas controls maintained their pregnancy. B cell-specific MyD88 and IL10 expression is essential for appropriate in utero development. IL10+B cells are involved in uterine blood flow regulation during pregnancy. Finally, B cell-specific CD19, MyD88 and IL10 expression influences susceptibility towards preterm birth.
Clinical Relevance of Gastroesophageal Cancer Associated SNPs for Oncologic Outcome After Curative Surgery
Authors: Jung Jin-On , Wirsik Naita Maren , Nienhüser Henrik , Peters Leila , Müller-Stich Beat Peter , Hess Timo , Schüller Vitalia , Schumacher Johannes , Schmidt Thomas 
Published: September 2021

Abstract
Background
Gastric and esophageal cancers are malignant diseases with rising importance in Western countries. To improve oncologic outcome after surgery, it is essential to understand the relevance of germline mutations. The aim of the study was to identify and distinguish clinically relevant single-nucleotide polymorphisms (SNPs).

Patients and Methods
In total, 190 patients with curative oncological resections of gastric and distal esophageal adenocarcinomas at Heidelberg University Hospital were eligible for this study. Outcome differences were determined for each SNP by analysis of clinical variables, survival, and mRNA expression levels.

Results
Significant survival differences were found on univariate analysis for usual prognostic variables (such as pTNM) and for six SNPs. On multivariate survival analysis, the SNPs rs12268840 (intron variant of MGMT, p = 0.045) and rs9972882 (intron variant of STARD3 and eQTL of PGAP3, p = 0.030) were independent and significant survival predictors along with R status and pT/pN category. Group TT of rs12268840 had the highest rate of second primary carcinoma (30.4%, p = 0.0003), lowest expression of MGMT based on cis-eQTL analysis in normal gastroesophageal tissue (p = 1.99 × 10−17), and worst oncologic outcome. Group AA of rs9972882 had the highest rate of distant metastases pM1 (42.9%, p = 0.0117), highest expression of PGAP3 (p = 1.29 × 10−15), and worst oncologic outcome.

Conclusions
Two intron variant SNPs of MGMT and STARD3 were identified that were significant survival predictors and may influence tumor biology. The data indicate that DNA methylation (MGMT) and malfunction of GPI anchoring (PGAP3) are distinct mechanisms that are relevant for tumor progression and relapse.
Synthesis of Difluoroalkenes from Thiocarbonyl Compounds via Difluorothiiranes: Electrophilic Counterpart to Wittig-Type Difluoromethylidenation
Authors: Fuchibe Kohei , Yamada Atsushi , Hachinohe Kosei , Matsumoto Kana , Takayama Ryo , Ichikawa Junji 
Published: September 2021

Abstract
The synthesis of 1,1-difluoro-1-alkenes was achieved by the treatment of dithioesters and thioketones with trimethylsilyl 2-fluorosulfonyl-2,2-difluoroacetate in the presence of a proton sponge catalyst, namely, 1,8-bis(dimethylamino)naphthalene. The generated electrophilic difluorocarbene (:CF2) reacted with the thiocarbonyl functionalities to form 2,2-difluorothiirane intermediates, desulfurization of which afforded the products in a Barton–Kellogg-type difluoromethylidenation. The reaction described herein is an electrophilic counterpart to the Wittig-type (nucleophilic) difluoroalkene synthesis starting from carbonyl compounds. The electrophilic difluoromethylidenation facilitated the synthesis of sulfanylated and diarylated 1,1-difluoroalkenes, including sterically hindered ones, which are inaccessible by nucleophilic difluoromethylidenation.
Lower mortality rate in health workers and their families infected with COVID-19 associated pneumonia in Quetta, Baluchistan
Authors: Aslam Momina , Zehri Muhammad Tahir , Mandoklel HabibUllah , Kamal Rehana , Din Mohammad 
Published: September 2021

Objectives: A bunch of pneumonia cases in Wuhan, China, was caused by a novel beta-corona virus, (COVID-19) in December 2019 from where it spread rapidly across the globe. The aim of the study was to find out relevant reasons and offered suggestions to reduce the risk of infection and check clinical outcomes of the infected healthcare workers.
Methods: This study was conducted in COVID-19 Real Time Polymerase Chain Reaction (RT-PCR) laboratory, Bolan Medical Complex Hospital Quetta, Baluchistan from May to June 2020. Eight hundred (n=800) health workers and their families were included in this study. Data were obtained with standardized data collection forms shared by the WHO. Nasopharyngeal samples were collected following the WHO protocols. RNA was extracted and amplified using real time reverse transcriptase polymerase chain reaction (RT-PCR). Serum ferritin level, C-reactive protein, D-dimer and radiological results of the RT-PCR confirmed individuals were also recorded and analyzed.
Results: Among (n=800) health workers and their families 457 (57.1%) were COVID-19 PCR negative, 332 (41.5%) positive and 11 (1.4%) individuals were PCR positive but asymptomatic carriers, 234 (29.5%) were male and 103 (12.9%) were female. Mortality rate in our study was very low, only three patients (0.87%) died of this COVID-19 pneumonia.
Conclusion: Our results showed increased rate of positive cases with fortunately lower mortality rate, although this novel pneumonia was associated with acute respiratory distress syndrome ARDS and intensive care unit (ICU) admission. Timely decisions, risk awareness knowledge and supply of necessary equipments are inevitable for the control of such epidemics.
doi: https://doi.org/10.12669/pjms.37.7.4060
How to cite this:Aslam M, Zehri MT, Mandoklel H, Kamal R, Din M. Lower mortality rate in health workers and their families infected with COVID-19 associated pneumonia in Quetta, Baluchistan. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4060
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Donor Chimerism Study by Single Nucleotide Polymorphism using SYBR green based Real Time PCR
Authors: Nayyar Ayesha , Ahmed Suhaib 
Published: September 2021

Objective: To optimize and evaluate a real time PCR of Single Nucleotide Polymorphism by SYBR Green method for detection of donor chimerism after haematopoietic stem cell transplantation.
Methods: This descriptive study was conducted at Genetic Resource Centre (GRC) Lab Rawalpindi from Oct 2017 - Dec 2019. A total of twenty patients of post haematopoietic stem cell transplant with various haematological disorders were studied to see the status of donor chimerism by using SNP real time PCR using SYBR Green method and short tandem repeat PCR. These patients had undergone allogeneic HSCT from HLA-matched sibling donors at Pakistan Institute of Medical Science and Armed Forces Bone Marrow Transplant Centre.
Results: Real time PCR using SYBR Green was able to detect significant amount of chimerism in all 20 patients having undergone HSCT. Regarding precision of the real time PCR assay the mean value of donor chimerism was 94.1% (SD 3.96) and by STR PCR it was 95.1% (SD 1.41). The assay was found to be sensitive with a detection limit of <1%.
Conclusion: Our results demonstrate that SNP analysis by SYBR Green real time PCR may be used for the evaluation of chimerism status in patients having undergone HSCT with a sensitivity of <1%. Hence donor chimerism by this sensitive method can be used in monitoring of chimerism in post-transplant patients with various haematological disorders.
doi: https://doi.org/10.12669/pjms.37.7.4203
How to cite this:Nayyar A, Ahmed S. Donor Chimerism Study by Single Nucleotide Polymorphism using SYBR green based Real Time PCR. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4203
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pulmonary function parameters among marble industry workers in Lahore, Pakistan
Authors: Butt Imran Maqsood , Mustafa Tajammal , Rauf Shahnaz , Razzaq Anjum , Anwer Javaria 
Published: September 2021

Background: Occupational contact with dust particles is a well-known phenomenon, particularly in developing countries of the world. Crystalline silica present in marble dust is the main etiology of a rising prevalence of obstructive lung diseases in marble stone workers, who are in direct contact with marble dust in the surrounding environment during their regular work. The purpose of this study was to compare the pulmonary function parameters of workers in marble workshops and age matched healthy individuals in the Lahore District of Pakistan. Methods: The study included 164 male individuals, 82 individuals working in marble workshops and 82 healthy individuals from the same community. Data were collected through in-person interviews using a structured questionnaire after obtaining written consent. A Spiro Lab spirometry for pulmonary function tests was used to identify any change in the lung function parameters. FVC% (forced vital capacity), FEV 1 (forced expiratory volume in first second) and FEV1 / FVC ratio were evaluated. Results: Mean age in the exposed group (marble workers) and non-exposed group (healthy individuals) were 29.92 ± 6.19 and 30.58 ± 6.37 years, respectively. The mean years of work experience of the exposed group was 11.92 ± 5.67 years. A statistically insignificant difference was observed between marble exposed workers & healthy individuals from the demographic variables. Lung function parameters in marble workers exhibited a highly significant (P < 0.001) decrease in FVC%, FEV1 & FEV1 / FVC ratio when compared to healthy individuals. Seventy-one percent of marble workers had abnormal pulmonary parameters whereas 34% of workers had restrictive pulmonary impairment. Marble workers who had worked for more than 15 years had a highly significant risk of developing abnormal pulmonary function (P < 0.001). Conclusion: Continuous exposure to marble dust deteriorates the lung function of marble workers.
Integrating evidence-based interventions in clinical settings in Jordan: a policy brief
Authors: Alzaatreh Mohammad , Al-Maraira Obay A. , Abu Tabar Nazih , Alsadi Mohammad R. , Khrais Huthaifah , Abunab Hamzeh Y , Kasasbeh Khaled M. , Almaani Mohammad , Khalil Malek 
Published: September 2021

Background: Evidence-based nursing practice (EBNP) is considered a major and very important global paradigm shift. Unfortunately, most healthcare providers and researchers embrace the concept of evidence-based practice (EBP) without integrating this concept in clinical settings. The current situation of EBP and new practice guidelines utilization in Jordan are scarce. This policy brief aimed to discusses the process of utilizing nursing EBP in clinical settings in Jordan. Methods: The authors adopted an action plan utilizing a systematic approach to develop and implement specific strategies and policies to integrate EBP in clinical settings in Jordanian hospitals. We present an experience of one country in terms of introducing a policy brief to establish an EBP policy accompanied by developing an EBP unit in the hospital's country. Results: A comprehensive description of this policy is provided with reference to the eminent steps of policy analysis and evaluation. In fact, EBP policies and clinical practice guidelines should keep a live document and revise regularly or as needed. Overall, the authors suggest the development of a unit for EBP to deal with issues related to clinical practice guidelines. Conclusions: Expected outcomes for the introduction of the EBP unit and its policy include increase research utilization and accelerated adoption of new evidence, increase the quality of care provided, increase patient, staff, and managers satisfaction, and decrease staff workload by reducing complications associated with medical errors and outdated interventions.
Anaemia in primary care: iron deficiency and anaemia of chronic disease
Authors: Perry Margaret 
Published: September 2021

Iron deficiency anaemia and anaemia of chronic disease are commonly seen in primary care. Margaret Perry discusses how to recognise, diagnose and manage these conditions This article will look at iron deficiency anaemia and anaemia of chronic disease. Both are problems encountered frequently at a global scale and in the primary care setting. Both conditions can potentially affect any age, although anaemia of chronic disease is more common among older adults. It is hoped that the information provided will give general practice nurses and nurse prescribers greater confidence in the recognition, diagnosis, and management of these conditions, to improve patient care.
Quantification of gaze reaction time in infants with Pediatric Perimeter
Authors: Datta Sourav , Chilakala Koteswararao , Vempati Sandeep , Oleti Tejopratap , Kulkarni Jaishree , Murki Srinivas , Gaddam Pramod , Satgunam PremNandhini 
Published: September 2021

Purpose
We quantified the eye/head (gaze) reaction time in infants to establish a normative database for the Pediatric Perimeter device. Additionally, we tested the hypothesis that gaze reaction time will reduce with age.

Methods
A cross-sectional study was conducted. Healthy infants between 3 to 10 months of age were recruited. Peripheral visual field stimuli (hemifield and quadrant stimuli) were presented in the Pediatric Perimeter device. Infant’s gaze to these stimuli was observed, documented in real time, and video recorded for offline analysis.

Results
A total of 121 infants were tested in three age group bins [3–5 months, n = 44; >5–7 months, n = 30 and >7–10 months, n = 47]. Overall, 3–5 months old had longer reaction time when compared to the older infants particularly for stimuli presented in the quadrants (Kruskal-Wallis, p<0.038). A significantly asymmetric difference (p = 0.025) in reaction time was observed between the upper (median = 820ms, IQR = 659-1093ms) and lower quadrants (median = 601ms, IQR = 540-1052ms) only for the 3–5 months old infants.

Conclusion
This study provides the normative gaze reaction time of healthy infants. With increase in age, there is reduction in reaction time and disappearance of reaction time asymmetry in quadrant stimuli. The longer reaction time for upward gaze could be due to delayed maturation of neural mechanisms and/or decreased visual attention.
Obszar zamieszkiwania, status prawny i kierunki aktywności gospodarczej Wołochów/Vlachów w średniowieczu i epoce wczesnonowożytnej
Authors: Czamańska Ilona 
Published: September 2021

Niniejszy artykuł poświęcony będzie kwestii zasięgu osadnictwa wołoskiego, prawa wołoskiego i jego funkcjonowania oraz społeczno-gospodarczej roli środkowoeuropejskich i bałkańskich Vlachów. Materiał źródłowy, jakim dysponujemy, nie pozwala nam wytyczyć jakiegoś wyraźnego kierunku ekspansji Wołochów jako etnosu, zwłaszcza że na niektórych terenach ewoluował on bardzo szybko, niewątpliwie jednak w momencie, gdy w źródłach się pojawiają, widoczni są od Półwyspu Chalkidiki po Karpaty. Obserwując funkcjonowanie prawa wołoskiego możemy zaobserwować podobny jego rozwój na całym terenie, na którym było ono stosowane, niezależnie od tego, czy były to państwa o tradycji zachodnioeuropejskiej, bizantyńsko-prawosławnej, czy Imperium Osmańskie. Także ewolucja tego prawa przebiegała podobnie i w podobnym czasie. Możemy zaobserwować następujące etapy tej ewolucji: 1. do XIV wieku kształtowanie się systemu społecznego i samorządowego wspólnot wołoskich 2. wiek XIV–XVI: procesy osadnicze i intensywna kolonizacja na prawie wołoskim 3. wiek XVI–XVIII: podejmowanie przez część Vlachów zajęć rolniczych i utrata przez nich prawa wołoskiego 4. wiek XV–XVIII: wykorzystanie zasad prawa wołoskiego do budowy statusu prawnego Pograniczy Wojskowych. 5. wiek XIV–XVIII: przechodzenie knezów, wojewodów i primićurów do stanu szlacheckiego lub warstwy timariotów. Wołosi, mimo pozornie prymitywnego sposobu życia i gospodarowania odegrali ważną rolę cywilizacyjną, umożliwiając wykorzystanie gospodarcze trudno dostępnych i niebezpiecznych terenów.
Zwitterion coordination to configurationally flexibled10cations: synthesis and characterization of tetrakis(betaine) complexes of divalent Zn, Cd, and Hg
Authors: van Terwingen Steven , Wendland Léana , Kalf Irmgard , Fränzl Holger , Englert Ulli 
Published: September 2021

AbstractThed10ions MII(M = Zn, Cd, Hg) and four equivalents of the neutral zwitterion trimethylglycine (betaine, bet) aggregate to discrete six-coordinated cationic complexes. With nitrate as counter anions, solids of the composition [M(bet)4](NO3)2·H2O are obtained. Their structural characterization reveals close relationship: they crystallize in metrically similar unit cells adopting three different subgroups of a hypothetical aristotype. In all cases, the divalent cations exhibit a strongly distorted coordination sphere in which two betaine ligands bind with both carboxylato O atoms and the other two with only one oxygen to the cation. Non-coordinating O atoms of different betaine ligands act as hydrogen bond acceptors towards co-crystallized water molecules. At least for the Pearson-soft HgIIcations, this coordination is unexpected: to the best of our knowledge, HgIIcomplexes with four carboxylato ligands have not yet been characterized. Without the necessity for charge balancing, the composition of zwitterion complexes is dominated by steric requirements and possibly by competition with alternative dipole molecules such as solvent water.
Preparation of CoGe2-type NiSn2 at 10 GPa
Authors: Leineweber Andreas , Wetzel Marius Holger , Martin Stefan , Shang Shun-Li , Liu Zi-Kui 
Published: September 2021

Abstract
An unprecedented NiSn2 intermetallic with CoGe2-type crystal structure has been recovered (at ambient conditions) after high-pressure high-temperature treatment of a Ni33Sn67 precursor alloy at 10 GPa and 400 °C. The orthorhombic structure with Aeam space group symmetry is pseudotetragonal. Based on the evaluation of powder X-ray diffraction data, lattice parameters of a = b = 6.2818 Å and c = 11.8960 Å have been determined. Complicated line broadening and results of a further microstructure analysis, however, imply a defective character of the crystal structure. First-principles calculations with different model structures and a comparison with structural trends in the literature suggest that at the high-pressure high-temperature conditions a CuAl2-type crystal structure might be stable, which transforms to the recovered CoGe2-type crystal structure upon cooling or the release of pressure.
Orbital-selective electronic excitation in phase-change memory materials: a brief review
Authors: Chen Nian-Ke , Wang Bai-Qian , Wang Xue-Peng , Li Xian-Bin 
Published: September 2021

Abstract
Ultrafast laser-induced phase/structural transitions show a great potential in optical memory and optical computing technologies, which are believed to have advantages of ultrafast speed, low power consumption, less heat diffusion and remote control as compared with electronic devices. Here, we review and discuss the principles of orbital-selective electronic excitation and its roles in phase/structural transitions of phase-change memory (PCM) materials, including Sc0.2Sb1.8Te3 and GeTe phases. It is demonstrated, that the mechanism can influence the dynamics or results of structural transitions, such as an ultrafast amorphization of Sc0.2Sb1.8Te3 and a non-volatile order-to-order structural transition of GeTe. Without thermal melting, these structural transitions have the advantages of ultrafast speed and low power consumption. It suggests that the orbital-selective electronic excitation can play a significant role in discovering new physics of phase change and shows a potential for new applications.
Reverie, Schmaltz, and the Modernist Imagination
Authors: Kieffer Alexandra 
Published: September 2021

AbstractIn a review of 1895, Henry Gauthier-Villars described Claude Debussy’s Prélude à l’après-midi d’un faune as “musique de rêve,” a descriptor that has been attached to Debussy’s style ever since. Partly because of the importance of the Prélude within his compositional development, the distinctive sound of Debussy’s “dream music” has often been understood as a response to the hermetic and difficult literary style of French Symbolists, especially that of Stéphane Mallarmé. Yet Gauthier-Villars’s appellation of “musique de rêve” also invoked a specifically sonic (and largely forgotten) set of cultural reference points, an aural backdrop crucial for understanding Debussy’s early style in the 1880s and early 1890s—the widespread cultivation of the topos of reverie in French music in the final two decades of the nineteenth century. Settings of Baudelaire, Verlaine, and Mallarmé by Debussy and his young contemporaries around 1890 were infused with signifiers of dream and reverie that trace back to salon genres of the 1870s and that cross-pollinated with the harmonic language of the newly fashionable valse lente in the early 1880s. Hearing Debussy’s early works in the context of this reverie topos and its aural kinship to the popular valse lente sheds light on the extent to which the radical idiosyncrasy so vaunted by modernists was constantly evolving in tandem with—and could never truly free itself from—an aural culture defined by mass production, repetition, and cliché.