bluuebunny/crossref_metadata_2025_split huggingface dataset:
An importance of matrix-metalloprotease determination in urine of patients with bladder cancer
Authors: Tkachuk Vladimir N. , Al-Shukri Adel S. , Danilchenko Dmitriy I. 
Published: January 2021

The aimof this work is to estimate an influence of a depth and an extent of differentiation of neoplastic process on 2 and 9 matrix-metalloprotease levels in urine of patients with bladder cancer.
Patients and methods.71 patients with bladder cancer have been investigated. 14 patients with chronic cystitis were included in an experimental group and 45 patients without bladder diseases were included in a control group, patients without urinary tract obstructions and infections were included in a control group. A level of metalloprotease was identified by a cimographic method.
Results.It has been proved that enzymes MMP-2 and MMP-9 of urine proteolysis are high sensitive markers of bladder cancer occurrence and their concentration depends on a depth of invasion and an extent of tumor differentiation, and shows a disease course prognosis.
Conclusion.It is reasonably to identify MMP-2 and MMP-9 of urine by the cimographic method for diagnostics and noninvasive determination of a depth of invasion and an extent of bladder cancer differentiation.
Voix féminines dans les romans de Frances Sheridan : du bâillonnement à la transgression
Authors: Maffre Valérie 
Published: January 2021

<p>Bohaterki powieści Frances Sheridan wydają się uosabiać wszelkie cnoty, wcielając w życie postulat skromności zgodny z oczekiwaniami formułowanymi wobec osiemnastowiecznych kobiet. Do tego stopnia potrafią „trzymać język na wodzy”, że prozę Sheridan można na pierwszy rzut oka postrzegać niczym literacką wersję popularnych wówczas poradników dobrego wychowania. Niemniej szczegółowa analiza języka, składni, toku rozumowania i kobiecej narracji powieści Sheridan ukazuje, do jakiego stopnia powściągliwość i opanowanie bohaterek są wybrane czy wrodzone, na ile zaś zostały zewnętrznie narzucone. W wyznaniach formułowanych przez kobiety w powieściach epistolarnych Sheridan można nieraz usłyszeć inny głos, wówczas narracja przybiera formę dialogu kwestionującego pełną rezerwy postawę bohaterek.</p>
Preliminary Discussion on Several Problems Related to the Divisor Function
Authors: Wang Yongmin 
Published: January 2021

This paper is divided into three parts to discuss the divisor function. It mainly combines the high power sum of the divisor function to study the solution number of the polynomial with integer coefficients "g(x)=0(modq)", and to improve some of the conclusions in the second chapter of Additive Theory of Prime Numbers and prove the improved conclusions.
Childhood homes of interior architects in Turkey
Authors: Celebi Merve , Hasirci Deniz 
Published: January 2021

The design of home interiors is important for an individual, especially in childhood, when one’s character and psychological development is in progress. In this study, the aim is to explore the social and physical aspects of childhood homes of interior architects and their effects on their professional lives, and to understand the possible reflections of these special places on their current designs. Within this framework, the study was conducted with eight internationally recognised Turkish interior architects, with online interviews and sketchbooks, depending on the memories of the participants’ childhood homes, and data were obtained regarding the interpretation of these special places, as well as their influence on their current design approaches and productions. Findings included understanding which aspects of the participants’ homes were conveyed to their current productions in terms of preferences, approach and style. The results have implications on the interior architecture profession as well as interior architecture education.

Keywords: Childhood home environment, Turkish interior architects.
Efficacy and Acceptability of Parent-only Group Cognitive Behavioral Intervention for Treatment of Anxiety disorder in Children and Adolescents: A Meta-analysis of Randomized Controlled Trials
Authors: Yin Bangmin , Teng Teng , Tong Lyu , Li Xuemei , Fan Li , Zhou Xinyu , Xie Peng 
Published: January 2021

Abstract
Background: Anxiety disorder is the most prevalent mental disorder among children and adolescents, causing significant psychosocial problems and physical health conditions. Cognitive behavioral therapy (CBT) is an effective treatment for anxiety disorder in children and adolescents. And parent-only CBT is an alternative treatment for childhood anxiety disorder, which includes psychologists and parents rather than children in the treatment. As a new type of CBT, parent-only CBT has some advantages. However, it remains unclear whether parent-only CBT interventions are effective for treating children and adolescents with anxiety disorder.Methods: In this study, we evaluated the efficacy (the mean change scores of the anxiety rating scale from baseline to post-treatment，standardized mean difference SMD) and acceptability（the proportion of patients in the treatment group who withdrew from treatment early for any reason， risk ratios RRs） of parent-only cognitive behavioral therapy (CBT) for children and adolescents with anxiety disorder. We searched electronic databases, including PubMed, Cochrane Library, Embase, Web of Science, ProQuest, and PsycINFO from inception to June 2019. We included randomized controlled trials (RCTs) comparing parent-only CBT either with waitlist (WL), or CBT with parents in children and adolescents with anxiety disorder.Results: Finally, six RCTs with 407 participants were included in the meta-analyses. In terms of efficacy, pooled analyses indicated that parent-only CBT was significantly more effective than WL for reducing anxiety symptoms with SMD of −0.72 (95% CI −1.41 to −0.03, p = 0.04), and more remission rate with RR of 4.33 (37.96% vs. 6.85%, 95% CI 1.82 to 10.27, p = 0.0009) at post-treatment. And our analyses showed no evidence that parent-only CBT had significantly greater efficacy than CBT with parents with SMD of 0.21 (95% CI −0.09 to 0.50, p = 0.17). Acceptability in the parent-only CBT group was not significantly different to the WL group with RR of 0.92 (95% CI 0.52 to 1.62, p = 0.77), and was significantly worse than in the CBT with parents group with RR of 1.93 (95% CI 1.05 to 3.57, p = 0.03).Conclusions: Current evidence indicates that parent-only CBT can be an alternative and acceptable intervention for treating children and adolescents with anxiety disorder.
Nursing Instructors’ Perception of Clinical Education Competencies: A Qualitative Study
Authors: Beiranvand Shourangiz , Kermanshahi Sima Mohammad  Khan , Memarian Robabeh 
Published: January 2021

Abstract
Background: Clinical education competencies are a core requirement for clinical nurse instructors, contributing toward better the learning outcomes of students in the clinical settings. Awareness of nursing instructor's perception is essential for designing nursing professional development programs. This study aimed to explore nursing clinical instructors’ perception of the essential competencies for clinical education. Methods: A qualitative design, based on the content analysis approach was used. Eighteen clinical nursing instructors and five nursing students from Lorestan University of Medical Science(LUMS), were selected via a purposeful sampling method. Data were collected using a semi structured in-depth interview method, from October 2018 to February 2019. The interviews were recorded, transcribed verbatim, and analyzed with using Graneheim and Lundman methods. Results: Analysis of nursing instructors' perceptions of clinical education competencies identified four main categories and eight sub-categories. The main categories included; (I) tasks oriented education; (II) guiding and supporting nursing students; (III) organizing communication skills and (IV) professional-ethical role modeling Conclusions Although academic clinical faculties and part time clinical nursing instructors reported a high level of knowledge and confidence in their ability to establish communication skills, role modeling and nursing students’ supervision, Part time clinical nursing instructors, also identified the need for additional support for their clinical teaching roles. They were not prepared enough for clinical teaching roles; their perception of clinical educational skills was tasks oriented education. The development, implementation, and evaluation of curriculum based on clinical competency with structured mentoring processes for part time clinical nursing instructors are recommended, in order to meet the knowledge gap that has been created.
Effectiveness of Indapamide/amlodipine Single-pill Combination in Patients With Isolated Systolic Hypertension: Post-hoc Analysis of the ARBALET Study
Authors: Kobalava Zh , Kolesnik Eteri , Shavarova E , Goreva L , Karapetyan L 
Published: January 2021

Abstract
Background: Isolated systolic hypertension (ISH) is a major cause of morbidity and mortality. This study evaluated the effectiveness of treatment with an indapamide/amlodipine single-pill combination (SPC) in outpatients with uncontrolled ISH aged over 55 years in real-life clinical practice.Methods: This was a post-hoc analysis of the subgroup of patients with ISH from ARBALET, a 3-month, multicenter, observational, open-label study conducted in Russia among patients with grade I or II hypertension who were either uncontrolled on previous antihypertensive treatment or treatment-naïve. The effectiveness of indapamide/amlodipine SPC was assessed by the change in office systolic blood pressure (SBP) and the rate of target SBP (<140 mmHg) achievement at 2 weeks, 1 month and 3 months, in four age groups: 55-59 years, 60-69 years, 70-79 years, and 80 years or older.Results: The ARBALET study recruited 2217 patients, of whom 626 had ISH and were included in this post-hoc analysis (mean age 66.1±7.8 years; 165 men [26.36%] and 461 women [73.64%]). Target SBP <140 mmHg was achieved in 43%, 75% and 93% of patients at 2 weeks, 1 and 3 months, respectively. SBP decreased from baseline by 18.8±10.5 mmHg, 27.2±10.6 mmHg and 31.8±9.9 mmHg at 2 weeks, 1 month and 3 months, respectively. In the groups of patients aged 55-59, 60-69, 70-79, and ≥80 years, SBP reductions at 3 months compared with baseline were -30.3±9.4, -32.4±9.7, -32.5±10.7, and -28.9±9.6 mmHg, respectively. Conclusion: This post-hoc analysis of the observational ARBALET study showed that indapamide/amlodipine SPC was associated with significant reductions in BP and high rates of target BP achievement in a broad age range of patients with ISH treated in routine clinical practice.Trial registration number: ISRCTN40812831
Meaningful Activities During COVID-19 and Association With Mental Health in Belgian Adults.
Authors: Cruyt Ellen , De Vriendt Patricia , de Velde Dominique Van , Oostra Kristine , De Letter Miet , De Pauw Robby , Calders Patrick , Vlerick Peter , Rodriguez-Bailón Maria , Szmalec Arnaud , Merchán-Baeza Jose , Fernández-Solano Ana , Vidaña-Moya Laura 
Published: January 2021

Abstract
Background: The spread of COVID-19 has affected people’s daily lives and the lockdown may have led to a disruption of daily activities and a decrease of people’s mental health. Aim: To identify correlates of adults’ mental health during the COVID-19 lockdown in Belgium and to assess the role of meaningful activities in particular. Methods: A cross-sectional web survey for assessing mental health (General Health Questionnaire), resilience (Connor-Davidson Resilience Scale), meaning in activities (Engagement in Meaningful Activities Survey) and demographics was conducted between April 24 and May 4, 2020. Hierarchical linear regression was used to identify key correlates. Results: Participants (N=1781) reported low mental health (M=14.85/36). In total, 42.4% of the variance in mental health could be explained by variables such as gender, having children, living space, marital status, health condition, and resilience (β= -.33). Loss of meaningful activities was strongly related to mental health (β= -.36) and explained 9% incremental variance (R2 change= .092, p<.001) above control variables.Conclusions: The extent of performing meaningful activities during the COVID-19 lockdown in Belgium is positively related to adults’ mental health. Insights from this study can be taken into account during future lockdown measures in case of pandemics.
Hydropathicity-Based Prediction of Pain-Causing NaV1.7 Variants
Authors: Xenakis Markos , Kapetis Dimos , Yang Yang , Gerrits Monique , Heijman Jordi , Waxman Stephen , Lauria Giuseppe , Faber Catharina , Westra Ronald , Lindsey Patrick , Smeets Hubert 
Published: January 2021

Abstract
Background: Mutation-induced variations in the functional architecture of the NaV1.7 channel protein are causally related to a broad spectrum of human pain disorders. Predicting in silico the phenotype of NaV1.7 variant is of major clinical importance; it can aid in reducing costs of in vitro pathophysiological characterization of NaV1.7 variants, as well as, in the design of drug agents for counteracting adhere pain symptoms.Results: In this work, we utilize spatial complexity of hydropathic eﬀects toward predicting which NaV1.7 variants cause pain (and which are neutral) based on the location of its mutation site within the NaV1.7 structure. For that, we analyze topological and scaling hydropathic characteristics of the atomic environment around NaV1.7’s pore and probe their spatial correlation with mutation sites. We show that pain-related mutation sites occupy structural locations in proximity to a hydrophobic patch lining the pore while clustering at a critical hydropathic-interactions distance from the selectivity ﬁlter (SF). Taken together, these observations can diﬀerentiate pain-related NaV1.7 variants from neutral ones, i.e., NaV1.7 variants not causing pain disease, with 80.5% sensitivity and 93.7% speciﬁcity [area under the receiver operating characteristics curve = 0.872]. Conclusions: Our ﬁndings suggest that maintaining hydrophobic NaV1.7 interior intact, as well as, a ﬁnely-tuned (dictated by hydropathic interactions) distance from the SF might be necessary molecular conditions for physiological NaV1.7 functioning. The main advantage for using the presented predictive scheme is its negligible computational cost, as well as, hydropathicity-based biophysical rationalization.
The Onset of the Last Interglacial and Fingerprints of Transient Atlantic Meridional Overturning Circulation
Authors: Gierz Paul , Knorr Gregor , Govin Aline , Capron Emilie , Sokolova Nadezhda , Werner Martin , Lohmann Gerrit 
Published: January 2021

Abstract
Transitions from glacials to interglacials are the largest climate shifts that occurred during the Quaternary. These glacial terminations are characterized by transient changes in the Atlantic Meridional Overturning Circulation (AMOC) and associated alterations in the northward heat transport. It has been a challenge to differentiate between early last interglacial or late penultimate glacial climate conditions at 129-131 ka (thousands of years before present). Neither simulations with a stable interglacial-type nor with a freshwater perturbed AMOC state have reproduced the reconstructed sea surface temperature (SST) fingerprint in the North Atlantic. As previous approaches failed to consider the highly transient nature of the climate system at ~130 ka, the potential of transient, deglaciating AMOC responses and the corresponding impact on North Atlantic SST has yet to be examined. In this study, we employ a fully coupled Atmosphere-Ocean General Circulation Model (AOGCM) equipped with a stable-oxygen isotope module to investigate the underlying AMOC dynamics at the onset of the Last Interglacial (LIG). We demonstrate that successfully capturing both the SST patterns and the calcite δ18O signature in planktonic foraminifera from North Atlantic marine sediment cores necessitates a transiently recovering AMOC. Furthermore, this critically depends on capturing the cold, glacial ocean state prior to the onset of the interglacial.
Effects of Cognition and Affect on Preventive Behaviors During the COVID-19 Pandemic: A Cross-Sectional Study in China
Authors: Shen Fei , Min Chen , Lu Ye , Chu Yajie 
Published: January 2021

Abstract
Background: The global outbreak of COVID-19 has become an international public health crisis. Specific antiviral treatments for COVID-19 are not yet available, and prevention is of particular importance to fighting the virus. This study tends to explore and compare the roles of cognitive and affective factors in predicting preventive behavior adoption during the COVID-19 pandemic in China.Methods: An online survey using a quota sampling method to collect responses from 3,000 Chinese adults was conducted from March 2, 2020 to March 23, 2020. Questions included sociodemographic features, coronavirus knowledge, negative emotion, risk perception, and behavioral responses. Multiple regression analyses were conducted to examine the predictors of behavioral responses toward COVID-19.Results: On average, respondents had low levels of knowledge about COVID-19 (the overall correct response rate was 7.5 percent). Most respondents reported moderate to strong negative emotions towards the virus (3.47 out of 5). The average reported perceived chance of infection was 23.89%. For behavioral responses, respondents reported low frequencies of going out for activities (1.98 out of 4) and high frequencies of taking preventive measures (3.22 out of 4). Behavioral responses toward COVID-19 were found to be determined by cognitive and affective variables. Knowledge was negatively related to frequency of going out for activities (β=-0.11, p<.001). Negative emotion (β=0.34, p<.001), and risk perception (β=0.05, p=.007) were positively associated with going out for activities. The explanatory power of affective variables (ΔR2=12.1%) was greater than cognitive variables (ΔR2 =1.0%). For preventive behaviors, knowledge was positively associated with preventive behaviors (β=0.22, p<.001). Negative emotion (β=-0.28, p<.001) and risk perception (β=-0.05, p=.002) were all negatively associated with preventive measures. Affective variables still showed stronger explanatory power (ΔR2=8%) than cognitive variables (ΔR2=4.4%) in predicting preventive behaviors. Conclusions: After the rising period of the COVID-19 outbreak in mainland China, cognitive and affective variables still played important roles in predicting behavioral responses. Compared with cognitive factor, affective factors demonstrated stronger explanatory power in predicting behavioral responses towards COVID-19. The findings may have implications for enhancing individual compliance with guidelines of adopting preventive behaviors in response to COVID-19.
Perceived Need for Treatment and Non-utilization of Outpatient Psychotherapy in Old Age: Two Cohorts of a Nationwide Survey
Authors: Gellert Paul , Lech Sonia , Kessler Eva-Marie , Herrmann Wolfram , Döpfmer Susanne , Balke Klaus , Oedekoven Monika , Kuhlmey Adelheid , Schnitzer Susanne 
Published: January 2021

Abstract
Objectives: Older adults with mental health problems may benefit from psychotherapy; however, their perceived need for treatment in relation with rates of non-utilization of outpatient psychotherapy as well as predisposing, enabling, and need factors proposed by Andersen’s Model of Health Care Utilization that account for these differences warrants further investigation.Method: We used two separate cohorts (2014 and 2019) of a German weighted nationwide telephone survey of German-speaking adults with N=12,197 participants. Across the two cohorts, 12.9% (weighted) reported perceived need for treatment for mental health problems and were selected for further analyses. Logistic Generalized Estimation Equations (GEE) was applied to model the associations between disposing (age, gender, single habiting, rural residency), enabling (education, general practitioner visit, general health status) non-utilization of psychotherapy (outcome) across cohorts in those with need for treatment (need factor).Results: In 2014/2019, out of 6,087/6,110 participants, 11.8%/14.0% reported perceived need for treatment due to mental health problems, which reflects a significant increase in prevalence from 2014 to 2019. Of those who reported perceived need for treatment, 36.4%/36.9% did not see a psychotherapist – where rates of non-utilization of psychotherapy were vastly higher in the oldest age (59.3/52.5%; 75+) category, than in the youngest (29.1/10.7%; 18-25 years). Concerning factors associated with non-utilization, multivariate findings indicated participation in the cohort of 2014 (OR 0.94), older age (Age 55-64 OR 1.02, Age 65-74 OR 1.47, Age 75+ OR 4.76), male gender (OR 0.83), lower educational status (OR 0.84), rural residency (OR 1.38), single habiting (OR 1.37), and seeing a GP (OR 1.39) to be related with non-utilization of psychotherapy; general health status was not significantly associated with non-utilization when GP contact was included in the model.Conclusion: There is a strong age effect in terms of non-utilization of outpatient psychotherapy. Individual characteristics of both healthcare professionals and patients and structural barriers may add to this picture. Effective strategies to increase psychotherapy rates in those older adults with unmet needs for treatment are required.
Respiratory Adaptation to Climate in Upper Palaeolithic Modern Humans: The Case of Sungir and Mladeč.
Authors: Stansfield Ekaterina , Mitteroecker Philipp , Vasilyev Sergey , Vasilyev Sergey , Butaric Lauren 
Published: January 2021

Abstract
When our human ancestors migrated out of Africa, they faced a considerably harsher climate, but the extent to which human cranial morphology has adapted to climate is still debated. In particular, it remains unclear when such facial adaptations arose in human populations. Here, we explore climate-associated features of face shape in a worldwide modern human sample using 3D geometric morphometrics and a novel application of reduced rank regression. Based on these data, we assess climate adaptations in two crucial Upper Palaeolithic human fossils, Sungir and Mladeč, both of which have been archaeologically associated with a boreal-to-temperate climate. We found several aspects of face shape, especially the relative dimensions of the external and internal nose as well as of the maxillary sinuses, that are strongly associated with temperature and humidity, even after accounting for auto-correlation due to geographical proximity of populations. For these features, both fossils revealed adaptations to a dry environment, with Sungir being strongly associated with cold and Mladeč with warm-to-hot temperatures. As both fossils are dated among the earliest recent modern humans in Europe, our results suggest a relatively fast rate of climate adaptation in human respiratory morphology.