bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withdrawal Notice: Identification of the Interaction between Angiotensin-converting Enzyme Residues and Severe Acute Respiratory Syndrome Coronavirus 2
Authors: Kadil Youness , Mouhcine Mohammed , Rahmoune Imane , Filali Houda 
Published: March 2021

The article has been withdrawn by the Editorial office of the journal Current Pharmaceutical Design. The decision is reached by all authors, for below reasons:

• Data been published should be updated.

• New approach of this study and new results mentioning the vaccine and its interaction with ACE2.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Anti-inflammatory Activity of Mollugo cerviana Methanolic Extract in
LPS-induced Acute Inflammatory RAW 264.7 Macrophages
Authors: Biju Prabath Gopalakrishnan , Antony Robina , Raveendran Jijin 
Published: March 2021

Background:
The management of acute inflammation, which arises from complex biological responses to harmful stimuli, is an important determinant in recovery of the system from an otherwise detrimental outcome such as septicemia. However, the side effects and limitations of current therapeutics necessitate the development of newer and safer alternatives. Mollugo cerviana is a common medicinal herb of the Indian subcontinent and has been traditionally used for its fever mitigating, anti-microbial and hepatoprotective action. We have already reported the rich presence of radical scavenging phytochemicals in the plant extracts and their strong antioxidant properties.

Objective:
In the present study, we have evaluated the anti-inflammatory effects of methanolic extract (ME) of the areal parts of M. cerviana in a lipopolysaccharide (LPS)-induced acute inflammatory cell culture model.

Method:
RAW 264.7 mouse macrophages cell were stimulated by the bacterial endotoxin LPS at a concentration of 1 µg/mL. Cytotoxicity and anti-inflammatory potential of ME were carried out.

Results:
M. cerviana extract concentration up to 150 µg/ml was found to be non-toxic to cells (MTT and NRU assay). LPS induces acute inflammation by binding to TLR-4 receptors, initiating downstream signalling cascade that result in pro-inflammatory cytokine secretion. Extract treatment at 100 µg/ml suppressed LPS-induced gene expression (qPCR) and secretion (ELISA) of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α, and the chemokine CCL2, indicating a dampening of the acute inflammatory cascade. LPS-induced elevation of ROS level (DCFDA method) was significant reduced by extract treatment. Nitric oxide production, as indicated by nitrite level, was significantly reduced post extract treatment.

Conclusion:
From this study, it is demonstrated that M. cerviana methanolic extract has potent anti-inflammatory effect in the in vitro acute inflammation model of LPS-stimulated RAW 264.7 cells. There is not reported study so far on the anti-inflammatory properties of M. cerviana in an LPS-induced acute inflammatory model which closely mimics a human bacteremia response. Hence, this study highlights the therapeutic potential of this extract as a source of anti-inflammatory lead molecules.
Investigations on Synergistic and Antioxidant Actions of Medicinal Plant-
Based Biosynthesis of Zinc Oxide Nanoparticles Against E.coli and K.
pneumonia Bacteria
Authors: Rafique Muhammad , Rashid Farzana , Pervaiz Iqra , Malik Husna , Kanwal Zakia , Gillani Syed Sajid Ali 
Published: March 2021

Introduction:
Bacterial resistance to multiple drugs is increasing at an alarming rate in current era and nanotechnology is one of the effective and novel approaches to overcome drug resistance.

Methods:
Zinc Oxide Nanoparticles (ZnO NPs) has stronger antibacterial activity and is regarded as bio-safe nanomaterial. The aim of present study is to synthesize the ZnO NPs using Aloe vera leaves extract and to investigate the synergistic effects and antioxidant actions of bio-synthesized ZnO NPs against gram negative bacteria E.coli and K. pneumoniae. The synergistic effect of β-lactam antibiotics (meropenem and ciprofloxacin) was tested along with ZnO NPs by using Kirby’s disc diffusion assay. The antioxidant activity was investigated by α, α-diphenyl-β-picrylhydrazyl (DPPH) method.

Results:
Results revealed that the antibacterial activity of the selected antibiotics was much enhanced by ZnO NPs than the antibiotics alone. The resistant antibiotic (ciprofloxacin) became sensitive when combined with ZnO NPs. The antioxidant activity reveals that biosynthesized ZnO NPs possess significantly higher (p<0.05) antioxidant activity (77%).

Conclusion:
The findings reveal that biosynthesized ZnO NPs have much more eco-friendly approach. It can act as a strong potentiator of β-lactam antibiotics and put forward the possibility to use them effectively in targeted drug delivery, pharmaceuticals and biomedical fields.
Alzheimer’s Disease: Pathogenesis and Therapeutic Interventions
Authors: Ogbodo John O. , Agbo Chinazom P. , Njoku Ugochi O. , Ogugofor Martins O. , Egba Simeon I. , Ihim Stella A. , Echezona Adaeze C. , Brendan Kenneth C. , Upaganlawar Aman B. , Upasani Chandrashekhar D. 
Published: March 2021

Background:
Alzheimer’s Disease (AD) is the most common cause of dementia. Genetics,
excessive exposure to environmental pollutants, as well as unhealthy lifestyle practices are often
linked to the development of AD. No therapeutic approach has achieved complete success in
treating AD; however, early detection and management with appropriate drugs are key to improving
prognosis.

Interventions:
The pathogenesis of AD was extensively discussed in order to understand the reasons
for the interventions suggested. The interventions reviewed include the use of different therapeutic
agents and approaches, gene therapy, adherence to healthy dietary plans (Mediterranean diet,
Okinawan diet and MIND diet), as well as the use of medicinal plants. The potential of nanotechnology
as a multidisciplinary and interdisciplinary approach in the design of nano-formulations
of AD drugs and the use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic
tools for early detection of Alzheimer’s disease were also discussed.
PEMETAAN KULTUR SEKOLAH UNTUK MENDISEMINASIKAN KEUNGGULAN: MODEL GUGUS DARI SEKOLAH INTI KE SEKOLAH IMBAS
Authors: Sukardi Joko Sri , Efianingrum Ariefa , Siswoyo Dwi 
Published: March 2021

Belum meratanya capaian kualitas pendidikan di sekolah dapat berimplikasi pada ketimpangan kualitas pendidikan antarsekolah. Pada era otonomi daerah, Pemerintah Daerah khususnya Dinas Pendidikan memiliki keleluasaan dan kewenangan dalam memajukan kualitas pendidikan di daerahnya. Pemetaan kultur sekolah yang efektif dengan model gugus penting dilakukan untuk mendapatkan gambaran kualitas serta mengetahui keunggulan dan kelemahan sekolah. Keunggulan sekolah inti dapat didiseminasikan kepada sekolah imbas. Keunggulan yang dimaksud meliputi kualitas akademik maupun non akademik. Praktik yang baik di sekolah inti dapat menjadi rujukan dan inspirasi bagi sekolah imbas. Sekolah imbas dapat mengadopsi dan mengadaptasinya untuk meningkatkan keunggulan sekolah. Sekolah imbas dapat menentukan keunggulan yang sesuai dengan konteks sekolah dan wilayahnya masing-masing. Dengan demikian, semua sekolah berpeluang untuk berkembang dalam memajukan sekolahnya dan ketimpangan kualitas pendidikan antarsekolah dapat diminimalisir. Kata kunci: Diseminasi, Kultur Sekolah, Model Gugus
COVID-19 Discourse on Twitter in Four Asian Countries: Case Study of Risk Communication
Authors: Park Sungkyu , Han Sungwon , Kim Jeongwook , Molaie Mir Majid , Vu Hoang Dieu , Singh Karandeep , Han Jiyoung , Lee Wonjae , Cha Meeyoung 
Published: March 2021

Background
COVID-19, caused by SARS-CoV-2, has led to a global pandemic. The World Health Organization has also declared an infodemic (ie, a plethora of information regarding COVID-19 containing both false and accurate information circulated on the internet). Hence, it has become critical to test the veracity of information shared online and analyze the evolution of discussed topics among citizens related to the pandemic.

Objective
This research analyzes the public discourse on COVID-19. It characterizes risk communication patterns in four Asian countries with outbreaks at varying degrees of severity: South Korea, Iran, Vietnam, and India.

Methods
We collected tweets on COVID-19 from four Asian countries in the early phase of the disease outbreak from January to March 2020. The data set was collected by relevant keywords in each language, as suggested by locals. We present a method to automatically extract a time–topic cohesive relationship in an unsupervised fashion based on natural language processing. The extracted topics were evaluated qualitatively based on their semantic meanings.

Results
This research found that each government’s official phases of the epidemic were not well aligned with the degree of public attention represented by the daily tweet counts. Inspired by the issue-attention cycle theory, the presented natural language processing model can identify meaningful transition phases in the discussed topics among citizens. The analysis revealed an inverse relationship between the tweet count and topic diversity.

Conclusions
This paper compares similarities and differences of pandemic-related social media discourse in Asian countries. We observed multiple prominent peaks in the daily tweet counts across all countries, indicating multiple issue-attention cycles. Our analysis identified which topics the public concentrated on; some of these topics were related to misinformation and hate speech. These findings and the ability to quickly identify key topics can empower global efforts to fight against an infodemic during a pandemic.
Voice-Based Conversational Agents for the Prevention and Management of Chronic and Mental Health Conditions: Systematic Literature Review
Authors: Bérubé Caterina , Schachner Theresa , Keller Roman , Fleisch Elgar , v Wangenheim Florian , Barata Filipe , Kowatsch Tobias 
Published: March 2021

Background
Chronic and mental health conditions are increasingly prevalent worldwide. As devices in our everyday lives offer more and more voice-based self-service, voice-based conversational agents (VCAs) have the potential to support the prevention and management of these conditions in a scalable manner. However, evidence on VCAs dedicated to the prevention and management of chronic and mental health conditions is unclear.

Objective
This study provides a better understanding of the current methods used in the evaluation of health interventions for the prevention and management of chronic and mental health conditions delivered through VCAs.

Methods
We conducted a systematic literature review using PubMed MEDLINE, Embase, PsycINFO, Scopus, and Web of Science databases. We included primary research involving the prevention or management of chronic or mental health conditions through a VCA and reporting an empirical evaluation of the system either in terms of system accuracy, technology acceptance, or both. A total of 2 independent reviewers conducted the screening and data extraction, and agreement between them was measured using Cohen kappa. A narrative approach was used to synthesize the selected records.

Results
Of 7170 prescreened papers, 12 met the inclusion criteria. All studies were nonexperimental. The VCAs provided behavioral support (n=5), health monitoring services (n=3), or both (n=4). The interventions were delivered via smartphones (n=5), tablets (n=2), or smart speakers (n=3). In 2 cases, no device was specified. A total of 3 VCAs targeted cancer, whereas 2 VCAs targeted diabetes and heart failure. The other VCAs targeted hearing impairment, asthma, Parkinson disease, dementia, autism, intellectual disability, and depression. The majority of the studies (n=7) assessed technology acceptance, but only few studies (n=3) used validated instruments. Half of the studies (n=6) reported either performance measures on speech recognition or on the ability of VCAs to respond to health-related queries. Only a minority of the studies (n=2) reported behavioral measures or a measure of attitudes toward intervention-targeted health behavior. Moreover, only a minority of studies (n=4) reported controlling for participants’ previous experience with technology. Finally, risk bias varied markedly.

Conclusions
The heterogeneity in the methods, the limited number of studies identified, and the high risk of bias show that research on VCAs for chronic and mental health conditions is still in its infancy. Although the results of system accuracy and technology acceptance are encouraging, there is still a need to establish more conclusive evidence on the efficacy of VCAs for the prevention and management of chronic and mental health conditions, both in absolute terms and in comparison with standard health care.
Strategi Pengarang Ghosty’s Menghadapi Persaingan Komik Digital (Studi pada Komik Ghosty’s)
Authors: Alricoh Elias Benny , Paramita Sinta , Pandrianto Nigar 
Published: March 2021

Technology is developing rapidly, technology products are created to provide convenience to the community, which is new media. When through the development of technology, the spread of comics is also widely spread, comics that were originally using print media are now developing using digital media. To disseminate comic content, digital comic authors now using social media to promote their comics to a large extent. So digital comic authors need a strategy to disseminate digital comic content, attract readers, and get collaborative offers to raise their name. In this research the authors used a descriptive qualitative analysis method, to find out the strategies used by Ghosty's comic authors in spreading, and raising their names. The author collected data by interviewing the author of Ghosty's Comic, and his friends at once readers to get the data needed in this research. The results of this reserach illustrate that it is important to use strategies to create interesting digital comic content so that the Ghosty's comics can get collaborations such as Tokopedia, Orang Tua Group, Line Webtoon.Teknologi berkembang dengan pesat, banyak produk teknologi diciptakan untuk memberikan kemudahan pada masyarakat, salah satunya adalah media baru. Saat melalui perkembangan teknologi medium penyebaran komik juga meluas, komik yang semula menggunakan media cetak kini berkembang menggunakan media digital. Untuk menyebarkan konten komik, pengarang komik digital kini menggunakan media sosial untuk mempromosikan komiknya ke kalangan yang luas. Maka pengarang komik digital memerlukan sebuah strategi untuk melakukan penyebaran konten komik digital, menarik pembaca, dan mendapatkan tawaran kolaborasi untuk membesarkan namanya. Pada penelitian ini penulis menggunakan metode kualitatif deskriptif analisis, untuk mengetahui strategi yang digunakan pengarang komik Ghosty’s dalam menyebarkan, dan membesarkan namanya. Penulis mengumpulkan data dengan melakukan wawancara dengan pengarang komik Ghosty’s, dan teman sekaligus pembacanya untuk mendapatkan data yang diperlukan dalam penelitian ini. Hasil dari penelitian ini menggambarkan bahwa pentingnya menggunakan strategi untuk membuat konten komik digital yang menarik sehingga dengan besarnya nama komik Ghosty’s bisa mendapatkan kolaborasi seperti Tokopedia, Orang Tua Group, Line Webtoon.
Hubungan Motif Penggunaan Informasi dalam Beauty Journal dengan Kepuasan Pengunjung Website Sociolla.com (Survei Terhadap Perempuan Pengguna Situs Sociolla.com)
Authors: Naftali Disha , Rusdi Farid 
Published: March 2021

Many ways are used to support the appearance properly one of which is to treat the body and use beauty products. Many quality products offered by Sociolla.com sometimes make users also confused to choose the best product for their conditions. With the Beauty Journal feature, users can find out in advance superior products that are in accordance with the user's skin condition, based on price, based on local brands and others. The purpose of this study was to determine the effect of the relationship between the motives for using information in the Beauty Journal with the satisfaction of Sociolla.com website visitors. This study uses a quantitative approach. The theoretical foundation used in this research is uses and gratification and online media. The independent variable in this study is the motive for using Beauty Journal information and the dependent variable is the level of satisfaction of website visitors at sociolla.com on the information in the Beauty Journal feature. Researchers used a purposive sampling technique with 100 respondent sample. Data collection was carried out by distributing questionnaires in the form of Google Forms consisting of 30 indicators. Data analysis techniques used correlation coefficients, simple linear regression analysis and coefficient of determination. The final result obtained is the motive for using information in the Beauty Journal to influence the satisfaction of visitors to the website sociolla.com.Banyak cara yang digunakan untuk menunjang penampilan dengan baik salah satunya adalah dengan merawat tubuh dan menggunakan produk kecantikan. Banyak produk yang berkualitas yang ditawarkan oleh Sociolla.com terkadang membuat pengguna juga bingung untuk memilih produk yang terbaik untuk kondisi mereka. Dengan adanya fitur Beauty Journal, pengguna bisa mencari tahu terlebih dahulu produk unggulan yang sesuai dengan kondisi kulit pengguna, berdasarkan harga, berdasarkan merek lokal dan lain-lain. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh hubungan motif penggunaan informasi dalam Beauty Journal dengan kepuasan pengunjung website Sociolla.com. Penelitian ini menggunakan pendekatan kuantitatif. Landasan teori yang digunakan dalam penelitian ini yaitu uses and gratification dan media online. Variabel independen pada penelitian ini adalah motif penggunaan informasi Beauty Journal dan variabel dependen adalah tingkat kepuasan pengunjung website sociolla.com terhadap informasi dalam fitur Beauty Journal. Peneliti menggunakan teknik purposive sampling dengan sampel sebanyak 100 responden. Pengumpulan data dilakukan dengan menyebarkan kuisioner berupa Google Forms yang terdiri dari 30 indikator. Teknik analisis data menggunakan koefisien korelasi, analisis regresi linear sederhana dan koefisien determinasi. Hasil akhir yang diperoleh adalah motif penggunaan informasi dalam Beauty Journal berpengaruh terhadap kepuasan pengunjung website sociolla.com.
Анализ и оценка последствий наводнения в г.Тулуне (Иркутская область)
Authors: Дугарова Г. Б. 
Published: March 2021

<span> Статья посвящена результатам оценки и анализа последствий наводнения, произошедшего в июне 2019 г. в г.Тулуне Иркутской области. Изучены теоретико-методологические аспекты социально-экономических исследований наводнений. Особое внимание автор уделяет обоснованию выбора методики оценки прямых экономических потерь. Определен ряд недостатков и проблем при использовании различных существующих методик. Проведен анализ отдельных составляющих экономического ущерба с учетом их разнородной природы и специфических особенностей. Несмотря на ограниченность, разрозненность и несопоставимость информации, поступающей из разных источников, представленный анализ и оценка охватывают ключевые виды жизнедеятельности и сектора экономики. В целом, по мнению автора, они дают реальную картину последствий наводнения в г. Тулуне. Исследование и его результаты основаны на обработке первичных данных.</span>
Арктическая корпорация: подступы к формированию новой теории (часть 1)
Authors: Пилясов А. Н. , Богодухов А О. 
Published: March 2021

<span>Радикальные отличия ресурсодобывающих транснациональных корпораций (ТНК) от таковых в обрабатывающей промышленности делают невозможным механическое копирование постулатов существующей теории ТНК на арктические ресурсные компании. Авторы предлагают формировать теорию арктических ресурсных ТНК на основе триады: OLI-парадигмы Д. Даннинга, концепции ресурсного цикла (цепочки) И. Комара и основ эволюционной экономики и экономической географии. Развитие ресурсных корпораций понимается как постоянное наращивание и диверсификация портфеля компетенций. Использование «мягких» критериев позволило выделить 19 ресурсных компаний, работающих в российской Арктике. Из них три</span><span class="myHorizontalScaleForEmDashSpaceBefore"> </span><span>–</span><span class="myHorizontalScaleForEmDashSpaceAfter"> </span><span>«Новатэк», «Газпромнефть» и «Норникель»</span><span class="myHorizontalScaleForEmDashSpaceBefore"> </span><span>–</span><span class="myHorizontalScaleForEmDashSpaceAfter"> </span><span>являются преимущественно арктическими. Ключевые характеристики арктических ТНК в аспекте предлагаемой авторами теории показаны на конкретных примерах деятельности российских компаний в последние два десятилетия.</span>
The Effect of Job Stress and Psychological Burnout on Child-care Teachers’ Turnover Intention: A Moderated Mediation Model of Gratitude
Authors:   Hanseo University, Hwang Yeoun Kyoung , Lee Chang Seek ,   Hanseo University
Published: March 2021

Introduction. Child-care teachers’ turnover intention is very high in Korea because of low wage and hard work which cause job stress and psychological burnout. There is need for research to reduce turnover intention using psychological variables such as gratitude. Our purpose in this study was to verify when gratitude affects the mediating effects of psychological exhaustion in the link between job stress and turnover intention of 234 childcare teachers in Korea. Study participants and methods. The participants in this study were 234 child-care teachers from Korea. Among the participants, 78.6% were married and 21.4% were single. The most common age group was 40s with 49.1%, 30s with 23.6%, 20s with 15.0%, and 50s with 12.3%. For analysis, we used SPSS Win.25.0 and PROCESS macro for SPSS 3.5 programs to do descriptive statistics analysis, reliability analysis, correlation analysis, and moderated mediation effect analysis. Results. First, turnover intention had a positive correlation with job stress (r = .506, p<.01) and psychological burnout (r = .571, p<.01), and a negative association with gratitude (r = - .339, p < .01). Second, conditional indirect effects of gratitude on the relationship between job stress and turnover intention through psychological burnout were significant (p < .001) when the gratitude value was low (M-1 SD), average (M), or high (M+1 SD). Therefore, the moderated mediation effect of gratitude was verified. Practical significance. This study found out that gratitude of childcare teachers alleviates their turnover intention. This result will be used as a model to reduce the degree of turnover intention by using the gratitude of child-care teachers.