bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Gut Microbiota with Efficacy of Chemotherapy in Patients with Diffuse Large B-cell Lymphoma
Authors: YUAN Li , ZHANG Yan , ZHANG Wei , WEI Chong , WANG Wei , ZHAO Danqing , ZHOU Daobin , LI Jingnan 
Published: June 2021

Abstract
The composition and diversity of gut microbiota (GMB) have been reported to be associated with the occurrence and progression as well as treatment outcome in many diseases. Our previous study demonstrated that the GMB was changed significantly and Proteobacteria phylum was the dominant microbiota in untreated diffuse large B-cell lymphoma (DLBCL) patients compared with healthy controls. This study aims to investigate the association of GMB with treatment outcomes in patients with DLBCL. 17 Patients with DLBCL and 18 healthy volunteers were recruited at Peking Union Medical College Hospital. The GMB of fecal samples was analyzed using 16S ribosomal RNA gene sequencing. We examined GMB compositions in 3 contexts: DLBCL patients (17) compared with healthy controls (18), DLBCL patients pretreatment (17) compared with posttreatment (17), and the association of GMB with chemotherapy treatment outcomes (10 complete remissions, 7 non-complete remisisons). We found that the GMB was changed considerably in posttreatment DLBCL patients. More specifically, the abundance of Proteobacteria phylum decreased significantly in patients following 4 courses of chemotherapy, although no significant difference from healthy comtrols(CG). In addition, the abundance of Lactobacillaceae, Lactobacillus, Lactobacillus fermentum were significantly higher and became dominant gut microbiota in DLBCL patients with complete remission, ,which may be associated with chemotherapy intervention and tumor extinction. Lactobacillus fermentum may have an inhibitory effect on DLBCL contributing to the disease remisison. The composition of gut microbiota in DLBCL patients changed from the healthy condition to the pretreatment condition, and then turned to the posttreatment condition after chemotherapy, which echoed the pathological succession of gut microbiota in DLBCL patients. Results from our current study together with previous research will provide a rational foundation for further investigation on the pathogenesis of gut microbiota in DLBCL to facilitate drug development and foster novel strategy for the better management of patients with DLBCL.
Novel Optical Solitons to the Perturbed Gerdjikov-Ivanov Equation Via Collective Variables
Authors: Hassan Zara , Raza Nauman , Gomez Francisco 
Published: June 2021

Abstract
The objective of this research is to study the collective variable (CV) technique to explore an important form of Schrödinger equation known as the Gerdjikov-Ivanov (GI) equation which expresses the dynamics of solitons for optical fibers in terms of pulse parameters. These parameters are temporal position, amplitude, width, chirp, phase, and frequency known as collective variables (CVs). This is an effective and dynamic mathematical gadget to obtain soliton solutions of non-dimensional as well as perturbed GI equations. Moreover, an established numerical scheme that is the fourth-order Runge-Kutta method is exerted for the numerical simulation of the revealing coupled system of six ordinary differential equations which represent all the CVs included in the pulse ansatz. The CV approach is used to determine the evolution of pulse parameters with the propagation distance and illustrated it illustrated it graphically. Furthermore, Figures show the compelling periodic oscillations of pulse chirp, width, frequency and amplitude of soliton. For various values of super-Gaussian pulse parameters, the numerical behavior of solitons to illustrate variations in CVs is provided. Other significant aspects with regards to the current investigation are also inferred.
Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema
Authors: Chang Jer-Hwa , Lee Yueh-Lun , Laiman Vincent , Han Chia-Li , Jheng Yu-Teng , Lee Kang-Yun , Yeh Chi-Tai , Kuo Han-Pin , Chung Kian Fan , Heriyanto Didik Setyo , Hsiao Ta-Chih , Wu Sheng-Ming , Ho Shu-Chuan , Chuang Kai-Jen , Chuang Hsiao-Chi 
Published: June 2021

Abstract
Background: Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was to investigate the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure. E-Cadherin-mediated contact inhibition of proliferation via the Hippo signaling pathway was investigated in Sprague-Dawley (SD) rats whole-body exposed to air pollution, and in alveolar epithelial A549 cells exposed to diesel exhaust particles (DEPs), E-cadherin-knockdown, and high-mobility group box 1 (HMGB1) treatment. Underlying epithelial differentiation, apoptosis, and senescence were also examined, and the interaction network among these proteins was examined. COPD lung sections were used to confirm the observations in rats. Results: Expressions of HMGB1 and E-cadherin were negatively regulated in the lungs and A549 cells by air pollution, and this was confirmed by knockdown of E-cadherin and by treating A549 cells with HMGB1. Depletion of phosphorylated (p)-Yap occurred after exposure to air pollution and E-cadherin-knockdown, which resulted in decreases of SPC and T1α. Exposure to air pollution and E-cadherin-knockdown respectively downregulated p-Sirt1 and increased p53 levels in the lungs and in A549 cells. Moreover, the protein interaction network suggested that E-cadherin is a key activator in regulating Sirt1 and p53, as well as alveolar epithelial cell differentiation by SPC and T1α. Consistently, downregulation of E-cadherin, p-Yap, SPC, and T1α was observed in COPD alveolar regions with particulate matter (PM) deposition. Conclusions: Our results indicated that E-cadherin-mediated cell-cell contact directly regulates the Hippo signaling pathway to control differentiation, cell proliferation, and senescence due to air pollution. Exposure to air pollution may initiate emphysema in COPD patients.
Biomechanical Evaluation and Comparison of Clinically Relevant versus Non-relevant Leg Length Inequalities
Authors: Michalik Roman , Rissel Viola , Miglorini Filippo , Siebers Hannah , Betsch Marcel 
Published: June 2021

Abstract
BackgroundLeg length inequalities (LLIs) are a frequent condition in every population. It is common clinical practice to consider LLIs of 2cm and more as relevant and to treat those. However, the amount of LLIs that need treatment is not clearly defined in literature and the effect of real LLIs on the musculoskeletal system above and below 2cm have not been studied biomechanically before.Research question: Are the spine and pelvis affected differently in patients with LLIs <2cm and ≥2cm.MethodsBy using surface topography, we evaluated 32 patients (10 females, 22 male) with real LLIs of ≥2cm (mean: 2.72cm; n=10) and compared their pelvic position and spinal posture to patients with LLIs <2cm (mean: 1.24cm; n=22) while standing and walking. All patients were measured with a surface topography system during standing and while walking on a treadmill. To compare patient groups, we used Student t-tests for independent samples.ResultsPelvic obliquity was significantly higher in patients with LLI ≥2cm during the standing trial (p=0.045) and during the midstance phase of the longer leg (p=0.023) while walking. Further measurements did not reveal any significant differences (p=0.06-0.706).ConclusionThe results of our study suggest that relevant LLIs of ≥2cm mostly affect pelvic obliquity and do not lead to significant alterations in the spinal posture during a standing trial. Additionally, we demonstrated that LLIs are better compensated when walking, showing almost no significant differences in pelvic and spinal posture between patients with LLIs smaller and greater than 2 cm. This study shows that LLIs ≥2cm can still be compensated; however, we do not know if the compensation mechanisms may lead to long-term clinical pathologies.
Title: Preoperative albumin-to-fibrinogen ratio predicts postoperative pulmonary complications in patients after minimally invasive esophagectomy
Authors: Peng Zhang , Song Zhao 
Published: June 2021

Abstract
Background
Postoperative pulmonary complications (PPCs) are the most common postoperative complications in patients with esophageal cancer. Prediction of PPCs by establishing a preoperative physiological function parameter model can help patients make adequate preoperative preparation, reduce treatment costs, and improve prognosis and quality of life. The purpose of this study was to investigate the relationship between albumin-to-fibrinogen ratio (AFR), prognostic nutritional index (PNI), albumin-to-globulin ratio (AGR), neutrophils-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and monocyte-to -lymphocyte ratio (MLR) and other preoperative laboratory tests and PPCs in patients after esophagectomy.
Methods
Retrospective analysis was performed on total 712 consecutive patients who underwent esophagectomy in the Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University from July 2018 to December 2020. Patients were divided into training (535 patients) and validation (177) groups for comparison of baseline data, perioperative indicators, and laboratory examination data. Receiver operating characteristic (ROC) curve analysis was used to evaluate the efficacy, sensitivity and specificity of AFR, and Youden’s index was used to calculate the cut-off values of AFR. Univariate and multivariate logistic regression analyses were used to assess the risk factors for PPCs in training group.
Results
112 (20.9%) in training group and 36 (20.3%) in validation group developed PPCs. The AUC value predicted by AFR using ROC curve analysis was 0.817, sensitivity 76.2% and specificity 78.7% in training group while AUC 0.803, sensitivity 69.4% and specificity 85.8%. Multivariate logistic regression analysis showed that smoking index, American Society of Anesthesiologists (ASA), AFR, and recurrent laryngeal nerve palsy were independent risk factors for PPCs.
Conclusion
Preoperative AFR can effectively predict the occurrence of PPCs in patients with esophageal cancer
Global carbon sequestration through continental chemical weathering in a climatic change context
Authors: Lechuga-Crespo Juan Luis , Sauvage Sabine , vanVliet Michelle , Ruiz-Romera Estilita , Probst Jean-Luc , Sanchez-Perez Jose-Miguel 
Published: June 2021

Abstract
Here, we simulate carbon dioxide (CO2) sequestration in 300 major world river basins (about 70% of global surface area) through carbonates dissolution and silicate hydrolysis. For each river basin, the daily timescale impacts under both the RCP 2.6 and RCP 8.5 climate scenarios were assessed relative to a historic baseline (1969-1999) using a cascade of models accounting for the hydrological evolution under climate change scenarios. Here we show that global temporal evolution of the CO2 uptake presents a general increase in the annual amount of CO2 consumed from 0.247 Pg C·y-1 to 0.261 and 0.273 Pg C·y-1, respectively for RCP 2.6 and RCP 8.5. Besides, despite showing a general increase for the global daily carbon sequestration, both climate scenarios present a decrease between June and August. Such projected changes have been mapped and evaluated against changes in hydrology, identifying hot spots and moments for the annual and seasonal periods.
Label Propagation Community Detection Algorithm Based on Density Peak Optimization
Authors: Ma Yan , Chen Guoqiang 
Published: June 2021

Abstract
Community structure detection in complex network structure and function to understand network relations, found its evolution rule, monitoring and forecasting its evolution behavior has important theoretical significance, in the epidemic monitoring, network public opinion analysis, recommendation, advertising push and combat terrorism and safeguard national security has wide application prospect. Label propagation algorithm is one of the popular algorithms for community detection in recent years, the community detection algorithm based on tags spread the biggest advantage is the simple algorithm logic, relative to the module of optimization algorithm convergence speed is very fast, the clustering process without any optimization function, and the initialization before do not need to specify the number of complex network community. However, the algorithm has some problems such as unstable partitioning results and strong randomness. To solve this problem, this paper proposes an unsupervised label propagation community detection algorithm based on density peak. The proposed algorithm first introduces the density peak to find the clustering center, first determines the prototype of the community, and then fixes the number of communities and the clustering center of the complex network, and then uses the label propagation algorithm to detect the community, which improves the accuracy and robustness of community discovery, reduces the number of iterations, and accelerates the formation of the community. Finally, experiments on synthetic network and real network data sets are carried out with the proposed algorithm, and the results show that the proposed method has better performance.
Visceral Adiposity Index and Atherogenic Index of Plasma as Useful Predictor of Cardiovascular Diseases Risk: Evidence From A Cohort Study in Iran
Authors: Hamzeh Behrooz , Pasdar Yahya , Mirzaei Narmin , Faramani Roya Safari , Najafi Farid , Shakiba Ebrahim , Darbandi Mitra 
Published: June 2021

Abstract
Background
Visceral Adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting Non-Communicable disease (NCDs). The aim of this study was to assess the association AIP and VAI with risk of cardiovascular diseases (CVDs).
Methods
This was a cross-sectional analysis conducted on 7362 individuals aged 35 to 65 years participated in Ravansar Non-Communicable Diseases (RaNCD) cohort study. AIP was calculated based on the value of triglyceride and high density lipoprotein cholesterol (HDL-C). VAI was calculated using Body mass index (BMI), waist circumference (WC), triglyceride, and HDL-C. All participants were stratified into three groups based on AIP and VAI tertiles. Logistic regression models were used to assess the association of AIP and VAI with CVDs.
Results
The mean of AIP and VAI was significantly higher in CVDs patients than in non-CVDs (P < 0.001). After adjusting for age, sex, BMI and physical activity the risk of CVDs in the second and third tertile of AIP were 1.22 (95% CI: 1.02, 1.45) and 1.40 (95% CI: 1.19, 1.66) times higher comparing to the first tertile, respectively. Risk of CVDs in the second and third tertile of VAI were 1.28 (95% CI: 1.06, 1.53) and 1.52 (95% CI: 1.25, 1.83) times higher than the first tertile, respectively; while adjusting for age, sex, hypertension and dyslipidemia and smoking.
Conclusion
According to the findings, AIP and VAI were positively associated with CVDs. Therefore, AIP and VAI can be useful in identifying high-risk subgroups of CVDs in general population.
Pro-angiogenic and osteogenic effects of adipose tissue-derived pericytes synergistically enhanced by Nel-like protein-1
Authors: An Hyun-Ju , Ko Kyung Rae , Baek Minjung , Chung Yoonhui , Lee Hyunhae , Kim Hyungkyung , Kim Do Kyung , Lee So-Young , Lee Soonchul 
Published: June 2021

Abstract

Background
One of important objectives of regeneration of vascularized tissues is to develop agents for osteonecrosis. We aimed to determine pro-angiogenic and osteogenic efficacies of adipose tissue-derived (AD) pericytes combined with Nel-like protein-1 (NELL-1) to investigate their therapeutic effects for osteonecrosis.
Methods
The experimental groups were configured to evaluate additional effects of NELL-1 on pericytes (i.e., Control, the group treated with only NELL-1, the group treated with only pericytes, and the group treated with pericytes and NELL-1). Tube formation and cell migration were assessed to determine pro-angiogenic efficacy. In vivo vessel formation was evaluated using the chorioallantoic membrane assay. A mouse model with a 2.5-mm necrotic bone fragment at the femoral shaft was used as a substitute for osteonecrosis in humans. Bone formation was assessed radiographically (plain radiographs, three-dimensional images, and quantitative analyses). Histomorphometric analyses were also performed. To identify factors related to additional effects of NELL-1, microarray, qRT-PCR analysis, and western blot were performed.
Results
The results for pro-angiogenic efficacy indicated there were synergistic effects of pericytes and NELL-1 on tube formation, cell migration, and vessel formation. For the results for osteogenic efficacy, the mouse models of osteonecrosis treated with pericytes and NELL-1 revealed the greatest bone formation in radiographic images and quantitative analyses, compared with other settings. The corresponding models treated with pericytes and NELL-1 revealed robust bone and vessel formation in the histomorphometric analyses. Using additional arrays, we found an association of FGF2 between the effects of NELL-1.
Conclusion
Combinational therapy using AD pericytes and NELL-1 has potential as a novel treatment for osteonecrosis.
Predictive Value of The Combined Detection of Platelets, D-Dimer, and Procalcitonin On Severe Heat Stroke
Authors: lei wang , shan jiang dai , Yi zhang , yu jia han , hua shen jun 
Published: June 2021

Abstract
BackgroundTo explore the clinical characteristics of patients with severe heat stroke, we explored the early sensitive indicators of heat stroke (HS) patients, with a view to early intervention for HS patients. MethodsFrom July 30, 2015 to October 5, 2020, 70 inpatients with severe heat stroke admitted to the Second Affiliated Hospital of Nantong University, Jiangsu Province were selected as the research objects. The general information and clinical test indicators of the patients were recorded, and all patients were assessed for acute physiology (APACH Ⅱ) upon admission. According to the severity of heatstroke, they were divided into three groups: control group (heat cramps and heat exhaustion), EHS, and CHS to compare the differences in indicators of each group. Further draw the receiver operating characteristic curve (ROC).Results1. According to the severity of heat stroke, 28 cases were divided into the control group, 24 cases in the EHS group, and 18 cases in the CHS group. The body temperature of the EHS group and the CHS group was significantly higher than that of the control group (both P<0.05), but there was no statistical difference in the body temperature of the EHS group and the CHS group; the DD, PCT, and APACH of the EHS group were significantly higher than those of the control group and the CHS group (both P＜0.05); PLT, CRP, Na, GLU of EHS group were lower than those of control group and CHS group (all P＜0.05), and the decrease of PLT was more significant; CHS group HbA1C was significantly higher than that of control group and EHS group (all P <0.05). 2. ROC curve analysis the areas under the curves of DD, PCT, and PLT are 0.670, 0.705, 0.791, respectively, the sensitivity is 40.48%, 100%, 73.81%, and the specificity is 96.43%, 32.14%, 78.57%, respectively. Using the combined analysis of the three series tests, the area under the curve was 0.838, the sensitivity was 71.43%, and the specificity was 85.71%. ConclusionsEHS patients have higher DD, PCT, APACH, but PLT, CRP, Na, and blood sugar are lower. At the same time, the significant decrease of PLT and the increase of PCT and DD may be early sensitive indicators of HS. The combined detection of the three can be used as a reference basis for early diagnosis of HS and critical illness.
HPLC Identification of Mare’s Milk and Its Mix with Cow’s Milk
Authors: Kurchenko Vladimir , Simonenko Elena , Sushynskaya Natalia , Halavach Tatsiana , Petrov Andrey , Simonenko Sergey 
Published: June 2021

Introduction. Mare’s milk is a valuable food product with medicinal properties. In combination with cow’s milk, it is used to create new functional foods. Efficient identification of mare’s milk, cow’s milk, and their mixes prevent falsification.
Study objects and methods. The protein composition of mare’s and cow’s milk whey and their mixes was analyzed by high performance liquid chromatography (HPLC) using an Agilent 1200 chromatograph with an Agilent G1315C diode array detector. Separation was performed using a column Machinery Nagel C 18 4.6×250, 5 μm.
Results and discussion. The standard HPLC method was optimized to analyse whey proteins in the milk samples. The separation of whey proteins included the following optimal parameters: chromatography time = 60 min, linear gradient of acetonitrile concentration = 0–50%, and sample volume for injection = 20 μl. Alpha-lactoalbumin proved to be the protein of mare’s milk and cow’s milk. The retention time of mare’s α-lactoalbumin was 45.16 min, and that of cow’s milk – 40.09 min. The differences in the retention time of α-lactoalbumin were associated with the presence of 33 amino acid substitutions in the primary structure of both milks. The areas of α-lactoalbumin peaks were used to calculate the amount of cow’s milk added to mare’s milk and the related percentage.
Conclusion. A HPLC analysis of whey proteins made it possible to determine up to 50 mL of added cow’s milk in 1 liter of mare’s milk.
Trends of potential waterborne diseases at different health facilities in Bamboutos Division, West Region, Cameroon: a retrospective appraisal of routine data from 2013 to 2017
Authors: Robertine Lontuo-Fogang , Payne Vincent Khan , Honorine Ntangmo Tsafack , Mounchili Souleman , Saturine Matango Murielle , Manjuh Bup Rita , Aboubakar Ngouyamsa Nsapkain , Roland Bamou 
Published: June 2021

Abstract
Many Cameroonian cities lack access to potable drinking water where populations rely on alternative water sources of doubtful quality. This study aimed at describing the trends and patterns of waterborne diseases (WBDs) reported in some health facilities in Bamboutos Division between 2013 and 2017 as baseline data towards understanding the profile of WBDs in this area. A retrospective review of clinical data kept on patients who visited the main health facilities in Bamboutos Division from January 2013 to December 2017 was conducted. Overall, 39.1% (n = 8,124) of total patients were positive for at least one WBD. Categories of WBDs were dysenteries (18.6%), gastroenteritis (4.2%), viral hepatitis (0.2%) and typhoid was the most preponderant (24.4%). The most affected age groups were those above 24 years but significant differences were observed only in 2013 and 2017. Distribution of potential WBDs was locality dependent. The highest prevalence of typhoid fever was recorded in Bameboro (35.4%), dysenteries in Bamedjinda (20.4%) and gastroenteritis (17.3%) in Bamekoumbou. The study shows very high overall prevalence of WBDs in some localities which could be considered as ‘hotspots’ of WBDs in Bamboutos. This suggests the urgent need for setting up measures to tackle the challenges of potable drinking water supply.