bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apropiaciones y representaciones: entre la patrimonialización y el arte urbano. Casa John McLean en Aylmer
Authors: Sanchez Gabriela 
Published: March 2021

Las apropiaciones que el arte urbano hace de determinados bienes patrimoniales han generado espacios controversiales que conducen a reflexiones más amplias tanto en el ámbito institucional como artístico. En este trabajo se analiza la intervención del artista J .Guénette a través de retratos de mujeres de la historia local sobre las superficies de la Casa McLean (1845) . Se plantean los límites y desbordes que se generan cuando el arte de estética contemporánea se apropia legalmente de bienes patrimoniales. Se cuestiona la manera en que ambos, patrimonio y arte, generan nuevos usos sociales del espacio público urbano. De esta forma se evidencia la coexistencia, pertenencia y apropiación del espacio patrimonial y del arte público, desde la contradictoria relación de lo efímero y la resistencia al paso del tiempo.
PEDIATRIC NURSES’ ATTITUDES REGARDING MALPRACTICE TENDENCIES AND PATIENT SAFETY CULTURE: A CASE OF TURKEY
Authors: TURAL BÜYÜK Esra , ÜNALDI BAYDIN Nihal , DÖRAL Özge 
Published: March 2021

Background: Pediatric nurses provide care to children, which is why they play an essential role in preventing medical errors and ensuring patient safety.
Objectives: This comparative and descriptive study was conducted to determine the attitudes of pediatric nurses in Turkey regarding malpractice tendencies and patient safety culture and to reveal the relationship between them.
Material and Methods: The study was conducted in the pediatric clinics of a university hospital and a public hospital in a metropolis in the northern region of Turkey. The study population included 142 nurses. A ‘Nurse Information Form’, a ‘Patient Safety Culture Scale (PSCS)’, and a ‘Malpractice Tendency Scale in Nursing (MTSN)’ were used to collect information. Data were analyzed by using SPSS 16 program, descriptive statistics, Independent Two-Sample t-test, one-way analysis of variance (ANOVA), Tukey test, Tamhane test, Mann Whitney U, Kruskal Wallis test and Pearson correlation tests.
Results: Nurses who had a master’s degree, made a medical error, and observed medical errors made by another colleague had a higher mean MTSN score (p
Gambaran Usia, Paritas, Tingkat Pendidikan, Status Pekerjaan, Dukungan Suami dan Tingkat Pengetahuan Ibu dalam Pemberian ASI Eksklusif
Authors: Polwandari Feling , Wulandari Sonia 
Published: March 2021

ASI eksklusif adalah pemberian ASI tanpa makanan tambahan lain pada bayi berumur 0-6 bulan. Berbagai penelitian membuktikan bahwa pemberian ASI Eksklusif dapat meningkatkan kekebalan dan kecerdasan anak. Oleh karena itu, pemerintah melalui Keputusan Menteri Kesehatan No. 450/MENKES/SK/VI/2004 menganjurkan pemberian ASI secara Eksklusif. Akan tetapi, anjuran tersebut belum dilakukan oleh semua ibu menyusui. Penelitian ini bertujuan untuk mengetahui gambaran usia, paritas, tingkat pendidikan, status pekerjaan, dukungan suami dan tingkat pengetahuan ibu dalam pemberian ASI eksklusif. Desain Penelitian ini adalah deskriptif dengan studi kasus dengan pengambilan sampel di Desa Pelamunan yang berjumlah 54 responden ibu yang mempunyai bayi usia 0-6 bulan. Pengumpulan data dilakukan dengan menggunakan kuesioner yang berisikan karakteristik dan pengetahuan ibu tentang ASI eksklusif. Hasil penelitian menunjukkan sebagian besar usia ibu menyusui tidak beresiko sebesar 84%, paritas multipara atau grandemultipara 77,5%, pendidikan rendah 83%, tidak bekerja 77%, suami yang sangat mendukung 81%, dan sebagian besar ibu menyusui berpengetahuan baik 79%. Petugas kesehatan diharapkan dapat memberikan penyuluhan pemberian ASI eksklusif kepada semua kalangan masyarakat, dan bagi peneliti lain untuk dapat melakukan penelitian mengenai mengatasi hambatan proses menyusui dengan metode yang lebih baik dari deskriptif.
Incidence, Risk Factors and Impact on Long-Term Outcome of Postoperative Delirium After Transcatheter Aortic Valve Replacement
Authors: Mauri Victor , Reuter Kevin , Körber Maria I. , Wienemann Hendrik , Lee Samuel , Eghbalzadeh Kaveh , Kuhn Elmar , Baldus Stephan , Kelm Malte , Nickenig Georg , Veulemans Verena , Jansen Felix , Adam Matti , Rudolph Tanja K. 
Published: March 2021

Background: The aim of the present study was to analyze incidence, risk factors, and association with long-term outcome of postoperative delirium (POD) after transcatheter aortic valve replacement (TAVR).Methods: Six hundred and sixty one consecutive patients undergoing TAVR were prospectively enrolled from January 2016 to December 2017. POD was assessed regularly during ICU-stay using the CAM-ICU test.Results: The incidence of POD was 10.0% (n = 66). Patients developing POD were predominantly male (65%), had higher EuroSCORE II (5.4% vs. 3.9%; P = 0.041) and were more often considered frail (70% vs. 26%; P &lt; 0.001). POD was associated with more peri-procedural complications including vascular complications (19.7 vs. 9.4; P = 0.017), bleeding (12.1 vs. 5.4%; P = 0.0495); stroke (4.5 vs. 0.7%; P = 0.025), respiratory failure requiring ventilation (16.7% vs. 1.8%; P &lt; 0.001), and pneumonia (34.8% vs. 7.1%; P &lt; 0.001). Consequently, patients with POD had significantly longer ICU- (7.9 vs. 3.2 days P &lt; 0.001) and hospital-stay (14.9 vs. 9.0 days; P &lt; 0.001), and higher in-hospital mortality (6.1 vs. 2.1%; P = 0.017). Logistic regression analysis identified male sex (odds ratio (OR) 2.2 [95% confidence interval (CI) 1.2–4.0); P = 0.012], atrial fibrillation [OR 3.0 (CI 1.6–5.6); P &lt; 0.001], frailty [OR 4.3 (CI 2.4–7.9); P &lt; 0.001], pneumonia [OR 4.4 (CI 2.3–8.7); P &lt; 0.001], stroke [OR 7.0 (CI 1.2–41.6); P = 0.031], vascular complication [OR 2.9 (CI 1.3–6.3); P = 0.007], and general anesthesia [OR 2.0 (CI 1.0–3.7); P = 0.039] as independent predictors of POD. On Cox proportional hazard analysis POD emerged as a significant predictor of 2-year mortality [HR 1.89 (CI 1.06–3.36); P = 0.030].Conclusion: POD is a frequent finding after TAVR and is significantly associated with reduced 2-year survival. Predictors of delirium include not only peri-procedural parameters like stroke, pneumonia, vascular complications and general anesthesia but also baseline characteristics as male sex, atrial fibrillation and frailty.
Sympathetic Nervous System Mediates Cardiac Remodeling After Myocardial Infarction in a Circadian Disruption Model
Authors: Wang Yuhong , Jiang Wanli , Chen Hu , Zhou Huixin , Liu Zhihao , Liu Zihan , Liu Zhihao , Zhou Yuyang , Zhou Xiaoya , Yu Lilei , Jiang Hong 
Published: March 2021

Background:Circadian rhythms have a considerable impact on the daily physiology of the heart, and their disruption causes pathology. Several studies have revealed that circadian disruption impaired cardiac remodeling after myocardial infarction (MI); however, the underlying brain-heart mechanisms remain unknown. We aim to discuss whether circadian disruption facilitates cardiac remodeling after MI by activating sympathetic nervous system.Methods:Rats were randomly divided into three groups: Sham group (Sham), MI group (MI), and MI+ circadian disruption group (MI+Dis); rats were treated with pseudorabies virus (PRV) injections for trans-synaptic retrograde tracing; rats were randomly divided into two groups: MI+ circadian disruption + Empty Vector+ clozapine N-oxide (CNO) (Empty Vector), and MI+ circadian disruption + hM4D(Gi)+ CNO [hM4D(Gi)].Results:Circadian disruption significantly facilitated cardiac remodeling after MI with lower systolic function, larger left ventricular volume, and aggravated cardiac fibrosis. Cardiac sympathetic remodeling makers and serum norepinephrine levels were also significantly increased by circadian disruption. PRV virus-labeled neurons were identified in the superior cervical ganglion (SCG), paraventricular nucleus (PVN), and suprachiasmatic nucleus (SCN) regions. Ganglionic blockade via designer receptors exclusively activated by designer drugs (DREADD) technique suppressed the activity of sympathetic nervous system and significantly alleviated the disruption-related cardiac dysfunction.Conclusion:Circadian disruption adversely affected cardiac remodeling after MI possibly by activating sympathetic nervous system, and suppressing sympathetic activity can attenuate this disruption-related cardiac dysfunction.
Photonic Curing of Nickel Oxide Transport Layer and Perovskite Active Layer for Flexible Perovskite Solar Cells: A Path Towards High-Throughput Manufacturing
Authors: Piper Robert T. , Daunis Trey B. , Xu Weijie , Schroder Kurt A. , Hsu Julia W. P. 
Published: March 2021

High-throughput roll-to-roll (R2R) manufacturing of perovskite solar cells (PSCs) is currently limited by thermal processes that take tens of minutes each, translating to impractically long annealing tools at high web speeds. In addition, PSCs are usually made with metal oxide transport layer materials that require high temperatures for thermal annealing. Here, we demonstrate the fabrication of PSCs using photonic curing, instead of thermal annealing, to convert NiOx directly from sol-gel precursors for hole transport layers and to crystallize methylammonium lead iodide (MAPbI3) active layers on flexible Willow® Glass substrates. Photonic curing uses short, intense pulses of light to process materials at a high speed, hence it is compatible with R2R manufacturing. We achieved power conversion efficiencies (PCEs) of 11.7% in forward-scan and 10.9% in reverse-scan for PSCs made with photonic cured NiOx and MAPbI3 films. Furthermore, both NiOx and MAPbI3 films could be processed with a single photonic curing pulse, with a web speed of 5.7 m/min, and still produce PCEs comparable to thermally annealed control samples. Based on the single-pulse photonic curing condition for each film, we project a web speed of 26 m/min, laying a pathway to high-throughput production of perovskite solar modules.
MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis
Authors: Wang Si , Xu Jing , Guo Yuanxu , Cai Yongsong , Ren Xiaoyu , Zhu Wenhua , Geng Manman , Meng Liesu , Jiang Congshan , Lu Shemin 
Published: March 2021

ObjectivesMounting evidence has demonstrated that microRNAs (miRNAs) participate in rheumatoid arthritis (RA). The role of highly conserved miR-15/107 family in RA has not been clarified yet, and hence investigated in this study.MethodsReverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to evaluate the expression of miRNAs and genes. Cell counting kit 8 (CCK-8) and FACS were used to detect proliferation and apoptosis. Protein expression was detected by using Western blotting. mRNA deep sequencing and cytokine antibody array were used to analyze differentially expressed genes, signaling pathways and cytokines.ResultsThe expression of miR-15a, miR-103, miR-497, and miR-646 was found decreased, while miR-424 increased in RA patients. MiR-424 and miR-497 were further investigated and the results showed that they could regulate the expression of multiple genes in rheumatoid arthritis synovial fibroblast (RASF) and affect signaling pathways. At the protein level, miR-497 mimic altered all the selected inflammation-related genes while miR-424 inhibitor only affected part of genes. MiR-497 mimic, rather than miR-424 inhibitor, had significant effects on proliferation and apoptosis of RASF. DICER1 was found to positively regulate the expression of miR-424 and miR-497, while DICER1 was also negatively regulated by miR-424. The increase of miR-424 could reduce miR-497 expression, thus forming a loop, which facilitated explaining the dysregulated miR-424 and miR-497 in RA.ConclusionThe miR-424 and miR-497 of miR-15/107 family affect cell proliferation and apoptosis in RA, and the proposed miR-424-DICER1-miR-497 feedback loop provides a novel insight into regulating miRNA expression and a candidate target for controlling RA.
miR-155 Contributes to the Immunoregulatory Function of Human Mesenchymal Stem Cells
Authors: Pers Yves-Marie , Bony Claire , Duroux-Richard Isabelle , Bernard Laurène , Maumus Marie , Assou Said , Barry Frank , Jorgensen Christian , Noël Danièle 
Published: March 2021

ObjectivesMesenchymal stem/stromal cells (MSCs) are widely investigated in regenerative medicine thanks to their immunomodulatory properties. They exert their anti-inflammatory function thanks to the secretion of a number of mediators, including proteins and miRNAs, which can be released in the extracellular environment or in the cargo of extracellular vesicles (EVs). However, the role of miRNAs in the suppressive function of MSCs is controversial. The aim of the study was to identify miRNAs that contribute to the immunomodulatory function of human bone marrow-derived MSCs (BM-MSCs).MethodsHuman BM-MSCs were primed by coculture with activated peripheral blood mononuclear cells (aPBMCs). High throughput miRNA transcriptomic analysis was performed using Human MicroRNA TaqMan® Array Cards. The immunosuppressive function of miRNAs was investigated in mixed lymphocyte reactions and the delayed type hypersensitivity (DTH) murine model.ResultsUpon priming, 21 out of 377 tested miRNAs were significantly modulated in primed MSCs. We validated the up-regulation of miR-29a, miR-146a, miR-155 and the down-regulation of miR-149, miR-221 and miR-361 in additional samples of primed MSCs. We showed that miR-155 significantly reduced the proliferation of aPBMCs in vitro and inflammation in vivo, using the DTH model. Analysis of miRNA-mRNA interactions revealed miR-221 as a potential target gene that is down-regulated by miR-155 both in primed MSCs and in aPBMCs.ConclusionHere, we present evidence that miR-155 participates to the immunosuppressive function of human BM-MSCs and down-regulates the expression of miR-221 as a possible inflammatory mediator.
Mining TCGA Data for Key Biomarkers Related to Immune Microenvironment in Endometrial cancer by Immune Score and Weighted Correlation Network Analysis
Authors: Guo Chengbin , Tang Yuqin , Zhang Yongqiang , Li Gen 
Published: March 2021

Background: Endometrial cancer (EC) is one of the most lethal gynecological cancers around the world. The aim of this study is to identify the potential immune microenvironment-related biomarkers associated with the prognosis for EC.Methods: RNA-seq data and clinical information of EC patients were derived from The Cancer Genome Atlas (TCGA). The immune score of each EC sample was obtained by ESTIMATE algorithm. Weighted gene co-expression network analysis (WGCNA) was used to identify the interesting module and potential key genes concerning the immune score. The expression patterns of the key genes were then verified via the GEPIA database. Finally, CIBERSORT was applied to evaluate the relative abundances of 22 immune cell types in EC.Results: Immune scores were significantly associated with tumor grade and histology of EC, and high immune scores may exert a protective influence on the survival outcome for EC. WGCNA indicated that the black module was significantly correlated with the immune score. Function analysis revealed it mainly involved in those terms related to immune regulation and inflammatory response. Moreover, 11 key genes (APOL3, C10orf54, CLEC2B, GIMAP1, GIMAP4, GIMAP6, GIMAP7, GIMAP8, GYPC, IFFO1, TAGAP) were identified from the black module, validated by the GEPIA database, and revealed strong correlations with infiltration levels of multiple immune cell types, as was the prognosis of EC.Conclusion: In this study, 11 key genes showed abnormal expressions and strong correlations with immune infiltration in EC, most of which were significantly associated with the prognosis of EC. These findings made them promising therapeutic targets for the treatment of EC.
Clinical Application of a Neurosurgical Robot in Intracranial Ommaya Reservoir Implantation
Authors: Liu Huan-Guang , Liu De-Feng , Zhang Kai , Meng Fan-Gang , Yang An-Chao , Zhang Jian-Guo 
Published: March 2021

Background: The Ommaya reservoir implantation technique allows for bypass of the blood-brain barrier. It can be continuously administered locally and be used to repeatedly flush the intracranial cavity to achieve the purpose of treatment. Accurate, fast, and minimally invasive placement of the drainage tube is essential during the Ommaya reservoir implantation technique, which can be achieved with the assistance of robots.Methods: We retrospectively analyzed a total of 100 patients undergoing Ommaya reservoir implantation, of which 50 were implanted using a robot, and the remaining 50 were implanted using conventional surgical methods. We then compared the data related to surgery between the two groups and calculated the accuracy of the drainage tube of the robot-assisted group.Results: The average operation time of robot-assisted surgery groups was 41.17 ± 11.09 min, the bone hole diameter was 4.1 ± 0.5 mm, the intraoperative blood loss was 11.1 ± 3.08 ml, and the average hospitalization time was 3.9 ± 1.2 days. All of the Ommaya reservoirs were successful in one pass, and there were no complications such as infection or incorrect placement of the tube. In the conventional Ommaya reservoir implantation group, the average operation time was 65 ± 14.32 min, the bone hole diameter was 11.3 ± 0.3 mm, the intraoperative blood loss was 19.9 ± 3.98 ml, and the average hospitalization time was 4.1 ± 0.5 days. In the robot-assisted surgery group, the radial error was 2.14 ± 0.99 mm and the axial error was 1.69 ± 1.24 mm.Conclusions: Robot-assisted stereotactic Ommaya reservoir implantation is quick, effective, and minimally invasive. The technique effectively negates the inefficiencies of craniotomy and provides a novel treatment for intracranial lesions.
Effects of Hearing Aid Noise Reduction on Early and Late Cortical Representations of Competing Talkers in Noise
Authors: Alickovic Emina , Ng Elaine Hoi Ning , Fiedler Lorenz , Santurette Sébastien , Innes-Brown Hamish , Graversen Carina 
Published: March 2021

ObjectivesPrevious research using non-invasive (magnetoencephalography, MEG) and invasive (electrocorticography, ECoG) neural recordings has demonstrated the progressive and hierarchical representation and processing of complex multi-talker auditory scenes in the auditory cortex. Early responses (&lt;85 ms) in primary-like areas appear to represent the individual talkers with almost equal fidelity and are independent of attention in normal-hearing (NH) listeners. However, late responses (&gt;85 ms) in higher-order non-primary areas selectively represent the attended talker with significantly higher fidelity than unattended talkers in NH and hearing–impaired (HI) listeners. Motivated by these findings, the objective of this study was to investigate the effect of a noise reduction scheme (NR) in a commercial hearing aid (HA) on the representation of complex multi-talker auditory scenes in distinct hierarchical stages of the auditory cortex by using high-density electroencephalography (EEG).DesignWe addressed this issue by investigating early (&lt;85 ms) and late (&gt;85 ms) EEG responses recorded in 34 HI subjects fitted with HAs. The HA noise reduction (NR) was either on or off while the participants listened to a complex auditory scene. Participants were instructed to attend to one of two simultaneous talkers in the foreground while multi-talker babble noise played in the background (+3 dB SNR). After each trial, a two-choice question about the content of the attended speech was presented.ResultsUsing a stimulus reconstruction approach, our results suggest that the attention-related enhancement of neural representations of target and masker talkers located in the foreground, as well as suppression of the background noise in distinct hierarchical stages is significantly affected by the NR scheme. We found that the NR scheme contributed to the enhancement of the foreground and of the entire acoustic scene in the early responses, and that this enhancement was driven by better representation of the target speech. We found that the target talker in HI listeners was selectively represented in late responses. We found that use of the NR scheme resulted in enhanced representations of the target and masker speech in the foreground and a suppressed representation of the noise in the background in late responses. We found a significant effect of EEG time window on the strengths of the cortical representation of the target and masker.ConclusionTogether, our analyses of the early and late responses obtained from HI listeners support the existing view of hierarchical processing in the auditory cortex. Our findings demonstrate the benefits of a NR scheme on the representation of complex multi-talker auditory scenes in different areas of the auditory cortex in HI listeners.
Lymphocyte-to-Monocyte Ratio Is the Independent Prognostic Marker of Progression in Patients Undergoing BCG-Immunotherapy for Bladder Cancer
Authors: Adamkiewicz Mateusz , Bryniarski Piotr , Kowalik Maksymilian , Burzyński Bartłomiej , Rajwa Paweł , Paradysz Andrzej 
Published: March 2021

IntroductionTransurethral resection of bladder tumor with subsequent BCG immunotherapy is the current gold standard in the treatment of high risk and some medium-risk non-muscle invasive bladder cancer. Clinical factors like stage, grade, age and gender are well-know predictors of progression to muscle-invasive bladder cancer. In recent years novel hematological biomarkers were shown to be independent predictors of progression. This study aimed to evaluate which of these novel markers has the highest prognostic value of progression in patients with bladder cancer receiving BCG immunotherapy.Materials and methodsWe retrospectively analyzed the data of 125 patients with non-muscle invasive bladder cancer who received BCG immunotherapy. Of these, 61 progressed to muscle-invasive disease or had high-grade recurrence. These patients were compared with the group who did not progress (n = 64). Clinical data including stage, grade, age, gender, smoking status and observational time was collected. Besides, information on blood count analysis was obtained from ambulatory digital charts. On this basis neutrophil-to-lymphocyte ratio (NLR), platelet-to lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) was counted and compared between groups.ResultsNLR, PLR and LMR were shown to be independent prognostic markers of progression in multivariable analysis. The model with stage, grade, age, gender, smoking status and LMR had the highest prognostic values of all models (area under curve [AUC] = 0.756). The cut-off point according to ROC curves for LMR was 3.25. Adding LMR to the baseline model including clinical variables significantly increased area under curve by 0.08 (p = 0.001). NLR and PLR did not increase areas under curve significantly to baseline model.ConclusionsLMR outperformed NLR and PLR for prediction of progression in patients with non-muscle-invasive bladder cancer receiving BCG immunotherapy. LMR, as an easily obtainable biomarker, should be incorporated to the present risk stratification models.