bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Assessment of English Learners in the Content Areas: An Exploratory Study in Fifth‐Grade Science
Authors: Grapin Scott E. , Llosa Lorena 
Published: August 2021

AbstractDynamic assessment (DA) seeks to understand learners’ abilities that are still developing by embedding mediation (i.e., contingent forms of assistance) into the assessment process. To date, DA studies have been carried out primarily in contexts focused on language learning. However, in content classrooms (e.g., science, math), English learners (ELs) are developing content and English language proficiency simultaneously and may therefore be able to demonstrate their learning more fully with mediation than in independent performance alone. This study applied DA to a novel context—the science classroom—and examined whether embedding mediation (in the form of contingent questions/probes) into two science assessment tasks yielded more complete and accurate information about what fifth‐grade ELs and their peers knew and could do. Findings indicated that mediation supported ELs in clarifying their science ideas that were initially communicated inexplicitly or imprecisely. Mediation also revealed that some non‐ELs’ seemingly accurate initial responses were not underpinned by science understanding. By offering a theoretically grounded approach to assessment that is dually responsive to students’ content and language learning needs, DA could help refute deficit views of ELs in the content areas and create more equitable opportunities for these students to demonstrate their content learning.
Theranostics for MRI‐guided therapy: Recent developments
Authors: Zhang Ziwei , Zhou Feng‐Lei , Davies Gemma‐Louise , Williams Gareth R. 
Published: August 2021

AbstractRecent advances in bioimaging, biochemistry, and bioinformatics have facilitated the development of personalized and precision medicine. Theranostics, combining imaging modalities and therapeutic agents, have garnered a lot of attention in this context, owing to their potential to monitor and control treatment for individual patients. A promising strategy to achieve this goal involves the development of therapy guided by magnetic resonance imaging (MRI). MRI has a high degree of soft tissue contrast, low invasiveness, high depth of penetration and good spatial resolution. MRI‐guided therapy could thus allow precise and time‐resolved assessment of disease conditions and therapeutic progression. This article will give a brief introduction to the principles of MRI, and describe recently developed strategies to produce MRI‐guided therapies. A number of theranostics based on T1, T2, or chemical exchange saturation transfer (CEST) MRI have been explored to track the route of drug carriers in vivo and image diseased tissue so as to enhance bioavailability, overcome complex delivery barriers, and assess therapeutic responses. In addition, the integration of thermal therapy and MRI imaging offers a strategy to noninvasively identify target areas, plan treatment, and provide real‐time assessment of the efficacy of tumor ablation. We also discuss advances in intelligent nanoparticles combining small molecule drugs, thermal treatment and multimodal imaging, arguing that these multifunctional agents can further improve therapeutic outcomes.
Risk factors for digital dermatitis in free‐stall‐housed, Canadian dairy cattle
Authors: de Jong Ellen , Frankena Klaas , Orsel Karin 
Published: August 2021

AbstractBackgroundA comprehensive analysis of the relation between digital dermatitis (DD) and cow and herd characteristics in Canadian dairies is currently lacking.MethodsA multilevel logistic regression analysis was performed using 12,260 cow records from 62 dairy farms to assess association between 27 cow and herd‐level variables, and presence of DD.ResultsThe odds for a cow to have at least 1 DD lesion were higher in first‐parity cows and those in later lactation (≥45 days in milk). Housing cows on a concrete base was associated with higher odds (OR 2.24) for DD when bedding was added once a week or less. Bedding the concrete base more frequently reduced odds for DD. Wood shavings or other bedding types were more positively associated with DD (OR 2.31 and 1.87, respectively) compared to sawdust. Also, the odds of DD were lower on farms with a scraping manure frequency of every 2 h compared to less frequent scraping (OR 0.54).ConclusionNine risk factors for DD were identified and quantified, with stall base, bedding type, and manure scraping frequency associated with lower odds of DD. DD prevalence could be reduced by implementing management practices for first‐parity cows, as they had higher odds of DD.
Interorganisational Collaboration in a Norwegian Prison—Challenges and Opportunities Arising from Interagency Meetings
Authors: Lahtinen Päivikki , Kajamaa Anu , Seppänen Laura , Johnsen Berit , Hean Sarah , Esko Terhi 
Published: August 2021

AbstractIn prison, the provision of care and the surveillance of inmates takes place in multiple locations with several often contradictory demands. Inmates may experience a fragmentation of services because of the separate silos in which criminal justice service and mental health professionals work and the distinct ways of working that develop within these. A greater alignment between services is required. This chapter focuses on interagency meetings in a Norwegian prison. These are groups that aim to develop an holistic perspective of the inmate’s situation and problems, and are seen as an innovative way to overcome the contradiction between ‘treatment’ and ‘punishment’ prison paradigms applied by the different professionals working together in the prison and mental health services. We analysed how the professionals interact at interagency meetings, and how they align their tasks, goals, roles and expertise to support the inmate’s imprisonment and rehabilitation. Our analysis illustrates the multiple ways in which this collective activity is conceptualised by the participants and then provides a model of interorganisational dynamics through which these collaborations may be fostered. By so doing, we have made suggestions about how to enhance interprofessional collaboration between prison and mental health services. The chapter also contributes to research on challenges and opportunities for collaboration in complex organisational settings.
Tracing the Historical Development of a Service Model for Interagency Collaboration: Contradictions as Barriers and Potential Drivers for Change
Authors: Rocha Paulo , Hean Sarah 
Published: August 2021

AbstractIn England and Wales, Liaison and Diversion (L&D) services work to facilitate integrated rehabilitative interventions orchestrated between Criminal Justice and Welfare systems to improve health and social care outcomes. A new L&D national model was introduced in 2014 to unify practice across all L&D sites. This chapter analyses the L&D’s historical activity before, during and after the process of implementation of this national model and provides a timeline whereby potential tensions and their underlying contradictions within and between the L&D and neighbouring services activity systems are identified. A case study of an L&D service in southern England is used by way of illustration and Cultural-Historical Activity Theory (CHAT) articulates the complexity of interactions between the professionals at the street-level. Our findings showed that fragmented information technology (IT) systems, both intra- and interagency, have been particularly problematic in this setting and that the national model was not apt to transform this situation. Fragmentation hinders information sharing and ultimately affects professionals’ capacity to collaborate. We suggest service providers at a local level engage in a dialogue with one another and that they are in a better position to govern local practices instead of having policy enforced unilaterally top-down.
Mentoring in Practice: Rebuilding Dialogue with Mentees’ Stories
Authors: Kloetzer Laure , Wells Jo , Seppänen Laura , Hean Sarah 
Published: August 2021

AbstractThe voluntary and community sector (VCS) is a key player in the support of prisoners and ex-prisoners in the English and Welsh criminal justice system. Organisational learning and innovation is urgently required in this sector to adapt to the current political and economic environment. The chapter describes exploratory efforts to introduce participatory methods drawn from Change Laboratory Methods and Clinics of Activity within a local VCS organisation that would help (re)build dialogue between stakeholders with the aim of promoting organisational learning and innovation. The intervention comprised an ethnographic phase of observing the staff, interviews with 19 key stakeholders, and a final developmental workshop with the staff. The analysis of these data by the researcher (first author) provided insight into the experience of mentors working in the voluntary sector as well as providing a trigger for dialogue in a subsequent workshop that used these data to establish dialogue between staff. These served as dialogical artefacts, introducing micro-dramas in the form of selected user stories. These dialogical artefacts triggered diverse reactions and analyses by the various participants, highlighting different elements than those anticipated by the researcher. We discuss the different readings of our research data by the researcher and staff members, presenting these two contrasting perspectives, and the implications this has for workplace development methods.
A COLAB Model of Workplace Transformation in the Criminal Justice Context
Authors: Hean Sarah , Aakjær Marie , Kloetzer Laure , Seppänen Laura , Kajamaa Anu , Lahtinen Päivikki , Murphy Tine 
Published: August 2021

AbstractThis chapter presents the COLAB model for promoting organisational learning and innovation with potential application in criminal justice-related organisations. We describe this model as a toolkit that built on the Change Laboratory model of workplace transformation but one augmented with the beneficial components of Activity Clinics, Boundary Crossing Workshops and Codesign methods and developed within the criminal justice context. Limitations and future directions for the model are discussed.
Should Nano-Particles be Weighed or Counted? Technical Considerations to In Vitro Testing Originated from Corpuscular Nature of Nano-Particles
Authors: Kałas Wojciech 
Published: August 2021

AbstractThe abundance of nanoparticles introduced to household products created the great expectations towards the application of nanotechnology in biology and medicine. That calls for cost-effective preliminary assessment of its cytotoxicity and biological activity. There are many attempts for creating proper guidance and standards for performing studies regarding nanoparticles. But still some important aspects crucial for in vitro testing of nanomaterials need more attention. Particulate nature is an obvious and widely unappreciated property of nanoparticles. In the context of in vitro studies, this property is critical, and it should be, but rarely is, considered when designing, performing, describing or interpreting the experiments involving the solid nanoparticles. First, we should be aware of relatively small and limited number of nanoparticles in the experimental setup. Even crude estimation of its number will be useful for proper interpretation of results. Second, we should not presume even distribution of particles in the solution, moreover we should expect that sedimentation and aggregation play an important role in interactions of nanoparticles with cells. In that case, expressing the dose in mass/volume units may lead as astray. Finally, the relation of size, weight, and number of nanoparticles makes comparisons of activity of nanoparticles of different sizes very complex. Estimations of number of nanoparticles in the dose should be an integral part of experiment design, its validation and interpretation.
Low-dose radiotherapy for painful osteoarthritis of the elderly: A multicenter analysis of 970 patients with 1185 treated sites
Authors: Rühle Alexander , Tkotsch Elisabeth , Mravlag Rainer , Haehl Erik , Spohn Simon K. B. , Zamboglou Constantinos , Huber Peter E. , Debus Jürgen , Grosu Anca-Ligia , Sprave Tanja , Nicolay Nils H. 
Published: August 2021

Abstract
Purpose
Painful osteoarthritis is common in elderly patients, and low-dose radiotherapy has been demonstrated to provide effective symptomatic treatment. We examined the analgesic effects of low-dose radiotherapy for osteoarthritis in the elderly aiming to reveal potential differences in the response rates relating to increasing age.

Methods
A retrospective analysis was performed at two university hospitals including elderly patients (≥ 65 years) undergoing radiotherapy for osteoarthritis between 2008 and 2020. Pain intensity and response were quantified using the numerical rating scale (NRS) and the Pannewitz score. Age groups were defined for young old (65–74 years), older old (75–84 years), and oldest old patients (≥ 85 years).

Results
In all, 970 patients with 1185 treated sites and a median age of 76 years were analyzed. Mean NRS was 66 at baseline (t0), 53 after radiotherapy (t1), and 44 at first follow-up (t2) (p < 0.001 for t0–t1, t1–t2, and t0–t2). At t1, 1.5% exhibited a Pannewitz score of 0 (no pain), 58.5% of 1–2 (less pain), 36.1% of 3 (equal pain), and 3.9% of 4 (worse pain), while at t2, pain response shifted towards 6.9% (0), 58.6% (1–2), 28.1% (3), and 6.3% (4). Pain response did not differ between age groups at t1 (p = 0.172) or t2 (p = 0.684). In addition, pain response after re-irradiation (n = 384 sites) was 61.0% and was comparable between age groups (p = 0.535).

Conclusion
Low-dose radiotherapy results in pain reduction in about two-thirds of treated sites with no difference relating to increasing age, showing that radiotherapy is an effective analgesic treatment for osteoarthritis even at advanced ages.
Diagnostics of infrapatellar saphenous neuralgia—a reversible cause of chronic anteromedial pain following knee surgery
Authors: Yang Schu-Ren , Hirschmann Michael T. , Schiffmann Alain , Kovacs Balazs K. , Gehweiler Julian , Amsler Felix , Hirschmann Anna 
Published: August 2021

Abstract
Objectives
To evaluate the impact of diagnostic nerve block and ultrasound findings on therapeutic choices and predict the outcome after concomitant surgery in patients with suspected neuropathy of the infrapatellar branch of the saphenous nerve (IPBSN).

Methods
Fifty-five patients following knee surgery with suspicion of IPBSN neuralgia were retrospectively included. Ultrasound reports were assessed for neuroma and postsurgical scarring (yes/no). Responders and non-responders were assigned following anesthetic injection of the IPBSN. The type of procedure (neurectomy/interventional pain procedure/other than nerve-associated therapy) and pain score at initial follow-up were recorded and patients were assigned as positive (full pain relief) or negative (partial/no pain relief) to therapeutic nerve treatment. Factors associated with a relevant visual analog scale (VAS) reduction were assessed using uni- and multivariate logistic regression models and chi-square for quantitative and qualitative variables (p ≤ 0.05).

Results
Responders (37/55) more often had an entrapment or an evident neuroma of the IPBSN (97% vs. 6%). A positive Hoffmann-Tinel sign (p = 0.002) and the absence of knee joint instability (p = 0.029) predicted a positive response of the diagnostic nerve block (90%; 26/29). In the follow-up after therapeutic nerve treatment, all patients with full pain relief showed neuromas or entrapment of the IPBSN. Patients negatively responding to therapeutic nerve treatment more frequently showed an additional knee joint instability (25% vs. 4%).

Conclusion
Selective denervation for neuropathic knee pain is beneficial in selected patients with significant VAS reduction after diagnostic nerve block. Non-responders following diagnostic nerve block but sonographic evidence of IPBSN pathologies need to be evaluated for other causes such as knee joint instability.

Key Points
• Sonographic diagnosis of neuroma or entrapment of the IPBSN is frequently seen in patients with anteromedial knee pain and leads to a good response to diagnostic nerve block following knee surgery.
• The vast majority of patients with clinical signs of IPBSN neuropathy and response to a diagnostic nerve block sustained full pain relief following therapeutic nerve treatment.
• Patients not responding to therapeutic IPBSN treatment have to be evaluated for other causes of anteromedial knee pain such as knee joint instability.
Population genetic structure of a major reef-building coral species Acropora downingi in northeastern Arabian Peninsula
Authors: Torquato Felipe , Bouwmeester Jessica , Range Pedro , Marshell Alyssa , Priest Mark A. , Burt John A. , Møller Peter R. , Ben-Hamadou Radhouan 
Published: August 2021

AbstractCurrent seawater temperatures around the northeastern Arabian Peninsula resemble future global forecasts as temperatures > 35 °C are commonly observed in summer. To provide a more fundamental aim of understanding the structure of wild populations in extreme environmental conditions, we conducted a population genetic study of a widespread, regional endemic table coral species,Acropora downingi, across the northeastern Arabian Peninsula. A total of 63 samples were collected in the southern Arabian/Persian Gulf (Abu Dhabi and Qatar) and the Sea of Oman (northeastern Oman). Using RAD-seq techniques, we described the population structure ofA. downingiacross the study area. Pairwise G’st and distance-based analyses using neutral markers displayed two distinct genetic clusters: one represented by Arabian/Persian Gulf individuals, and the other by Sea of Oman individuals. Nevertheless, a model-based method applied to the genetic data suggested a panmictic population encompassing both seas. Hypotheses to explain the distinctiveness of phylogeographic subregions in the northeastern Arabian Peninsula rely on either (1) bottleneck events due to successive mass coral bleaching, (2) recent founder effect, (3) ecological speciation due to the large spatial gradients in physical conditions, or (4) the combination of seascape features, ocean circulation and larval traits. Neutral markers indicated a slightly structured population ofA. downingi,which exclude the ecological speciation hypothesis.Future studies across a broader range of organisms are required to furnish evidence for existing hypotheses explaining a population structure observed in the study area. Though this is the most thermally tolerant acroporid species worldwide,A. downingicorals in the Arabian/Persian Gulf have undergone major mortality events over the past three decades. Therefore, the present genetic study has important implications for understanding patterns and processes of differentiation in this group, whose populations may be pushed to extinction as the Arabian/Persian Gulf warms.
Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature
Authors: Leibetseder Annette , Leitner Johannes , Mair Maximilian J. , Meckel Stephan , Hainfellner Johannes A. , Aichholzer Martin , Widhalm Georg , Dieckmann Karin , Weis Serge , Furtner Julia , von Oertzen Tim , Preusser Matthias , Pichler Josef , Berghoff Anna Sophie 
Published: August 2021

Abstract
Introduction
Adult brainstem gliomas (BSGs) are rare central nervous system tumours characterized by a highly heterogeneous clinical course. Median survival times range from 11 to 84 months. Beyond surgery, no treatment standard has been established. We investigated clinical and radiological data to assess prognostic features providing support for treatment decisions.

Methods
34 BSG patients treated between 2000 and 2019 and aged ≥ 18 years at the time of diagnosis were retrospectively identified from the databases of the two largest Austrian Neuro-Oncology centres. Clinical data including baseline characteristics, clinical disease course, applied therapies, the outcome as well as neuroradiological and neuropathological findings were gathered and analysed. The tumour apparent diffusion coefficient (ADC), volumetry of contrast-enhancing and non-contrast-enhancing lesions were determined on magnetic resonance imaging scans performed at diagnosis.

Results
The median age at diagnosis was 38.5 years (range 18–71 years). Tumour progression occurred in 26/34 (76.5%) patients after a median follow up time of 19 months (range 0.9–236.2). Median overall survival (OS) and progression-free survival (PFS) was 24.1 months (range 0.9–236.2; 95% CI 18.1–30.1) and 14.5 months (range 0.7–178.5; 95% CI 5.1–23.9), respectively. Low-performance status, high body mass index (BMI) at diagnosis and WHO grading were associated with shorter PFS and OS at univariate analysis (p < 0.05, log rank test, respectively). ADC values below the median were significantly associated with shorter OS (14.9 vs 44.2 months, p = 0.018).

Conclusion
ECOG, BMI, WHO grade and ADC values were associated with the survival prognosis of BSG patients and should be included in the prognostic assessment.
Optic nerve injury in preoperative imaging is associated with visual improvement outcome in endoscopic optic nerve decompression
Authors: Leitner Isabella , Andrianakis Alexandros , Gellner Verena , Kiss Peter , Andrianakis Damianos , Tomazic Peter Valentin 
Published: August 2021

Summary
Objective
To evaluate potential clinical parameters having an impact on visual outcome after endoscopic optic nerve decompression in acute optic neuropathy patients.

Methods
A retrospective chart review of patients with acute optic neuropathy, who underwent endoscopic optic nerve decompression between June 2001 and November 2018 at an academic center was performed. Patients were divided into groups according to visual improvement after surgical treatment (yes/no). Following clinical parameters were compared between groups: perioperative steroid use, evidence of optic nerve affection in preoperative neuroimaging, additional optic nerve sheath incision, surgery delay and preoperative C-reactive protein (CRP) levels. Further subgroups analyses were conducted based on etiology (trauma/tumor).

Results
Among 32 included cases, 16 patients (50%) reported visual improvement after endoscopic optic nerve decompression. There was no significant difference in visual improvement between etiology subgroups (trauma: n = 9/20 (45%) vs. tumor: n = 7/12 (58.3%), p = 0.465). Tumor subgroup patients with visual improvement had a significantly higher prevalence of optic nerve affection in preoperative neuroimaging than those without visual improvement (p = 0.018, φ = 0.683). Perioperative steroid administration was negatively associated with visual outcome (p = 0.034, φ = 0.375). Nerve sheath incision, surgery delay and preoperative CRP levels did not have a significant impact on visual outcome (p > 0.05).

Conclusion
Radiological findings can help as an indicator for surgical treatment since an affected optic nerve in preoperative neuroimaging resulted in better visual outcome after surgery. The use of steroids should be considered more carefully since it did not show any beneficial effect.