bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface model of the human red blood cell simulating changes in membrane curvature under strain
Authors: Kuchel Philip W. , Cox Charles D. , Daners Daniel , Shishmarev Dmitry , Galvosas Petrik 
Published: April 2021

Abstract
The highly deformable red blood cell (erythrocyte; RBC) responds to mechanically imposed shape changes with enhanced glycolytic flux and cation transport. Such morphological changes are produced experimentally by suspending the cells in a gelatin gel, which is then elongated or compressed in a special apparatus inside an NMR spectrometer. However, direct mathematical predictions of the shapes of the morphed cells have not been reported before. We used recently available functions in Mathematica to triangularize and then compute four types of curvature. The RBCs were described by a previously presented quartic equation in three dimensional (3D) Cartesian space. A key finding was the extent to which the maximum and minimum Principal Curvatures were localized symmetrically in patches at the poles or equators and distributed in rings around the main axis of the strained RBC. The simulations, on the nano-metre to micro-meter scale of curvature, suggest activation of only a subset of the intrinsic mechanosensitive cation channels, Piezo1, during experiments carried out with controlled distortions that persist for many hours. This view is consistent with a recent proposal for non-uniform distribution of Piezo1 molecules around the RBC membrane. On the other hand, if the curvature that gates Piezo1 is at a much finer length scale, then membrane tension will determine local curvature and micron scale curvature as described here will be less likely to influence Piezo1 activity. The geometrical reorganization of the simulated cytoskeleton helps understanding of the concerted metabolic and cation-flux responses of the RBC to mechanically imposed shape changes.
Electric Toy Car to Reduce Anxiety Before a Cardiac Catherization: Randomized Controlled Trial
Authors: Chambon Edouard , Fournier Emmanuelle , Tagorti Maha , Lecerf Florence , Chaouche Nadera , Ion Iolanda , Bojan Mirela , Cohen Sarah , Aerschot Isabelle Van , Kara Meriem , Batteux Clément , Petit Jérome , Hascoet Sébastien 
Published: April 2021

Abstract
Anxiety before an invasive intervention is associated in children with persistent psychological disorders. We studied the effect of the transfer to the catheterization room by an electric toy-car on the anxiety of children and their parents before a cardiac catheterization. Forty-eight children with a median age of 5.6 years [4.2-7.0] were randomized to either riding on an electric car to go to the catheterization laboratory or being transported lying supine on a gurney. Anxiety assessments were performed by a physician blinded to allocation group on the day before the procedure (T0) and at anesthesia induction (T1). The modified Yale score (mYPAS-SF) and visual analog scale for anxiety (VAS-A) were used in the children, and the VAS-A in the parents. The mYPAS-SF, VAS-A-child and the VAS-A-parent scores were significantly higher at T1 than at T0 (P < 0.001, P < 0.001, and P = 0.005, respectively). The primary outcome (the median mYPAS-SF score at T1) was not significantly different in the two groups when males and females were combined. At T1, the VAS-A-child score, however, was significantly lower in the intervention than the control group (22 versus 55, P < 0.001). In the boys, the median mYPAS-SF score at T1 was significantly lower in the intervention group (25.0 versus 51.0, P = 0.024). No difference was observed in girls. The VAS-A parent score was lower at T1 in the intervention group (60 versus 87, P = 0.05). Conclusion: Riding to the catheterization laboratory on an electric toy car decreased anxiety at anesthesia induction in boys and also decreased parental anxiety.Clinical trial Registration: Registration number: ID-RCB: 2019-A00459-48. Date of registration: March 27th 2019.
Role of the Trace Amine Associated Receptors 5 (TAAR5) in Sensorimotor Functions
Authors: Kalinina Daria , Ptukha Maria , Goriainova Anastasia , Merkulyeva Natalia , Kozlova Alena , Volnova Anna , Gainetdinov Raul , Musienko Pavel 
Published: April 2021

Abstract
Monoamines are critical modulators of the sensorimotor neural networks. Using trace amine associated receptor 5 (TAAR5) knockout mice that express beta-galactosidase marker, we observed TAAR5 expression in the medial vestibular nucleus and Purkinje cells in the cerebellum suggesting that TAAR5 might be involved in gaze stabilization, vestibular and motor control. Accordingly, in various behavioral tests TAAR5-KO mice demonstrated lower endurance but better coordination and balance compared to wild type mice. Furthermore, we found specific changes in striatal local field potentials and motor cortex ECoG such as а decrease in delta andan increase in theta oscillations of power spectra respectively. The data obtained suggest that TAAR5 plays a considerable role in the regulation of postural stability, muscle force, balance and motor coordination during active movements, likely via modulation of monoaminergic systems on different levels of sensorimotor control, including brainstem, cerebellum and forebrain.
A nomogram for predicting the residual back pain after percutaneous vertebroplasty for osteoporotic vertebral compression fractures
Authors: Li Qiujiang , Long Xingxia , Shi Lin , Wang Yinbin , Guan Tao , Jiang Xiaocheng , Guo Donggeng , Lv Jinhan , Cai Lijun 
Published: April 2021

Abstract
Background: Current findings suggest that percutaneous vertebroplasty(PVP) is a suitable therapeutic approach for osteoporotic vertebral compression fractures (OVCFs). However, a significant minority of patients still experience residual back pain after PVP. The present retrospective study was designed to determine the risk factors for residual back pain after PVP and provides a nomogram for predicting the residual back pain after PVP.Methods: We retrospectively reviewed the medical records of patients with single-segment OVCFs who underwent bilateral percutaneous vertebroplasty. Patients were divided into group N and group R according to the postoperative VAS score. Group R is described as the VAS score of residual back pain≥4. Pre- and post-operative factors that may affect back pain relief were evaluated between two groups. Univariate and multivariate logistic regression analysis were performed to identify risk factors affecting residual back pain after PVP. We provided a nomogram for predicting the residual back pain and used the receiver operating characteristic curve (ROC), concordance index (c-index), calibration curve, and decision curve analyses(DCA) to evaluated the prognostic performance.Results: Among 268 patients treated with PVP, 37(13.81%) patients were classified postoperative residual back pain.The results of the multivariate logistical regression analysis showed that the presence of an intravertebral vacuum cleft(IVC)(OR 3.790, P=0.026), posterior fascia oedema(OR 3.965, P=0.022), server paraspinal muscle degeneration(OR 5.804, P=0.01; OR 13.767,P<0.001) and blocky cement distribution(OR 2.225, P=0.041) were independent risk factors for residual back pain after PVP. The AUC value was 0.780, suggesting that the predictive ability was excellent. The prediction nomogram presented good discrimination, with a C-index of 0.774(0.696~0.852), and was validated to be 0.752 through bootstrapping validation. The calibration curve of the nomogram demonstrated a good consistency between the probabilities predicted by the nomogram and the actual probabilities. The nomogram showed net benefits in the range from 0.06 to 0.66 in DCA.Conclusions: The presence of IVC, posterior fascia oedema, blocky cement distribution and severe paraspinal muscle degeneration were significant risk factors for residual back pain after PVP for OVCFs. Patients with OVCFs after PVP who have these risk factors should be carefully monitored for the possible development of residual back pain. We provide a nomogram for predicting the residual back pain after PVP.
Intraoperative acute correction versus postoperative gradual correction for tibial shaft fractures with multiplanar posttraumatic deformities using the hexapod external fixator
Authors: Liu Yanshi , Cai Feiyu , Liu Kai , Zhang Xingpeng , Li Hong , Fu Xuefei , Zhang Tao , Yusufu Aihemaitijiang 
Published: April 2021

Abstract
Background: The purpose of this study was to determine the differences in clinical outcomes, if any, between intraoperative acute correction and postoperative gradual correction for tibial shaft fractures with multiplanar posttraumatic deformities using the hexapod external fixator.Methods: We retrospectively analyzed 58 consecutive patients with tibial shaft fractures treated by the hexapod external fixator at our institution from January 2015 to April 2019. Twenty-three patients (Group Ⅰ) underwent intraoperative acute correction, from January 2015 to October 2016. Starting in November 2016, the other 35 patients (Group Ⅱ) all underwent postoperative gradual correction. The demographic data, operation duration, original residual deformities before correction, residual deformities after correction, and external fixation time were collected and analyzed. The clinical outcomes were evaluated by the Johner-Wruhs criteria at the last clinical visit.Results: All patients achieved complete bone union with a mean time of 28.7±4.6 weeks (range 21 to 37 weeks) in Group Ⅰ and 27.9±4.8 weeks (range 19 to 38 weeks) in Group Ⅱ (P>0.05). The operation duration in Group Ⅰ (88.9±7.7 minutes) was longer than that in Group Ⅱ (61.9±8.4 minutes), and there was a statistically significant difference (P<0.05). There were no statistically significant differences between the two groups in original residual deformities before correction and residual deformities after correction (P>0.05). The rate of postoperative complication was similar between the two groups. There was no statistical significance in demographic data and clinical outcomes between the two groups (P>0.05). Conclusions: There is no difference in clinical outcomes between intraoperative acute correction and postoperative gradual correction for tibial shaft fractures with multiplanar posttraumatic deformities using the hexapod external fixator. Postoperative gradual correction may shorten the duration in the operation room and decrease the potential intraoperative risk.
Structural descriptor for enhanced spin-splitting in 2D hybrid perovskites
Authors: Jana Manoj , Song Ruyi , Xie Yi , Zhao Rundong , Sercel Peter , Blum Volker , Mitzi David 
Published: April 2021

Abstract
Two-dimensional (2D) hybrid metal halide perovskites have emerged as outstanding optoelectronic materials and are potential hosts of Rashba/Dresselhaus spin-splitting for spin-selective transport and spin-orbitronics. However, a quantitative microscopic understanding of what controls the spin-splitting magnitude is generally lacking. Through crystallographic and first-principles studies on a broad array of chiral and achiral 2D perovskites, we demonstrate that a specific bond angle disparity connected with asymmetric tilting distortions of metal halide octahedra breaks local inversion symmetry and strongly correlates with computed spin-splitting. This distortion metric can serve as a crystallographic descriptor for rapid discovery of potential candidate materials with strong spin-splitting. Our work establishes that rather than global space group, local inorganic layer distortions induced via appropriate organic cations provide a key design principle to achieve strong spin-splitting in perovskites. New chiral perovskites reported here couple a sizeable spin-splitting with chiral degrees of freedom and offer a unique paradigm of potential interest for spintronics.
Selectivity of Guanine Scaffold in Anticancer Drug Development: A Computational Repurposing Approach
Authors: Sherin D. R. , Manojkumar T. K. 
Published: April 2021

Abstract
Drug repurposing is one of the modern techniques used in the drug discovery to find out the new targets for existing drugs. Insilico methods have a major role in this approach. We used 60 FDA approved antiviral drugs reported in the last 50 years to screen against different cancer cell receptors. The thirteen compounds selected after virtual screening are analyzed for their druggability based on ADMET parameters and found the selectivity of guanine derivatives- didanosine, entecavir, acyclovir, valganciclovir, penciclovir, ganciclovir and valacyclovir as suitable candidates. The pharmacophore model, AARR, suggested based on the common feature alignment, shows that the two fused rings as in guanine and two acceptors-one from keto-oxygen(A5) and other from the substituent attached to nitrogen of imidazole ring(A4) give the druggability to the guanine derivatives. The NBO analysis on N9 is indicative of charge distribution from the ring to substituents, which results in delocalization of negative character in most of the ligands. The molecular dynamics simulations also pointed out the importance of guanine scaffold, which stabilizes the ligands inside the binding pocket of the receptor. All these results are indicative of the selectivity of guanine scaffold in anticancer drug development, especially as PARP1 inhibitors in breast, ovarian and prostate cancer. As these seven molecules are already approved by FDA, we can safely go for further preclinical trials.
Lake Urmia level in 2020 based on satellite altimetry
Authors: Sorkhabi Omid Memarian 
Published: April 2021

Abstract
In this paper, the final output of the satellite altimetry on the surface of Lake Urmia is investigated. From 1995 onwards, the level of Lake Urmia has been declining. From 2015 to 2019, it has had a steady trend and there are not many changes, the main reason being the policies of reviving Lake Urmia. After 2019, there is an increase of about 1.5 meters, which is due to good rainfall this year, and after that, a decreasing trend is observed. In the middle of 2020, with the increase of precipitation, the level of the lake increases by about 20 cm and then reaches the level of 1271.5 meters again. However, after 2015, with the policies of Lake Urmia restoration, the downward trend has been controlled and the level has remained constant. However, these policies do not seem to be sufficient and there is a need to reconsider the water resources management in the region.
Selected ‘Starter Kit’ energy system modelling data for Algeria (#CCG)
Authors: Cannone Carla , Allington Lucy , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger 
Published: April 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to starting energy system modelling in developing countries, thereby causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Algeria, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and two stylized scenarios (Fossil Future and Least Cost) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Selected ‘Starter Kit’ energy system modelling data for Cameroon (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Walker Miriam Zachau , Halloran Claire , Hirmer Stephanie , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger 
Published: April 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to starting energy system modelling in developing countries, thereby causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Cameroon, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and three stylized scenarios (Fossil Future, Least Cost and Net Zero by 2050) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Selected ‘Starter Kit’ energy system modelling data for Chad (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger 
Published: April 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to starting energy system modelling in developing countries, thereby causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Chad, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and three stylized scenarios (Fossil Future, Least Cost and Net Zero by 2050) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Selected ‘Starter Kit’ energy system modelling data for Ethiopia (#CCG)
Authors: Cannone Carla , Allington Lucy , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger , Hirmer Stephanie 
Published: April 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to starting energy system modelling in developing countries, thereby causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Ethiopia, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and two stylized scenarios (Fossil Future and Least Cost) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Hematologic complications in a patient with Glycine soja polyagglutination following fresh frozen plasma transfusion
Authors: Jajosky R.P. , Cook L.O. , Manaloor E. , Shikle J.F. , Bollag R.J. 
Published: April 2021

Abstract
Polyagglutination is a rare and underdiagnosed condition, characterized by agglutination of red blood cells (RBCs) with almost all ABO-compatible adult sera. Polyagglutination can occur when a cryptantigen is exposed on RBCs via microbial enzyme activity. Because nearly all adults naturally produce antibodies against cryptantigens, transfusion of plasma can cause unexpected hemolysis and hematologic complications, such as thrombocytopenia and disseminated intravascular coagulation, in patients whose cryptantigens are exposed. We report a case of Glycine soja polyagglutination occurring in a 60-year-old African-American man with disseminated methicillin-resistant Staphylococcus aureus (MRSA) infection. Prior to transfusion, the patient developed severe anemia of unknown etiology. Following transfusion of 3 units of fresh frozen plasma (FFP), his RBC count could not be determined for 24 days because of RBC agglutination in his blood sample. In addition, the FFP transfusion correlated with the rapid development of severe, transfusion-refractory thrombocytopenia and anemia. The perplexed clinical team consulted the blood bank. A direct antiglobulin test demonstrated 1+ mixed-field reactivity with both monoclonal anti-IgG and anti-C3d. Lectin panel testing showed reactivity with only Glycine soja, confirming the condition. Subsequently, plasma components were avoided, and RBC and platelet (PLT) components were washed prior to transfusion. After a 44-day hospitalization involving the transfusion of 22 units of RBCs and 13 units of PLTs, the patient was discharged to a long-term care facility. The patient’s confounding hematologic complications can best be explained by polyagglutination, which developed secondary to the severe MRSA infection. The FFP transfusion likely passively transferred antibodies that bound to the patient’s RBC cryptantigens, leading to RBC agglutination and anemia. The development of severe thrombocytopenia may be related to cryptantigen exposure on the patient’s PLTs. Although difficult to identify, polyagglutination needs to be recognized to appropriately manage hemotherapy. The purpose of this case study is to report hematologic complications following FFP transfusion in a patient with Glycine soja polyagglutination, a rarely described condition.
Immunohematology

2017;33:51–55.