bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ehrlichia TRP effectors: moonlighting, mimicry and infection
Authors: Byerly Caitlan D , Patterson LaNisha L , McBride Jere W 
Published: April 2021

ABSTRACT
Intracellular bacteria have evolved various strategies to evade host defense mechanisms. Remarkably, the obligately intracellular bacterium, Ehrlichia chaffeensis, hijacks host cell processes of the mononuclear phagocyte to evade host defenses through mechanisms executed in part by tandem repeat protein (TRP) effectors secreted by the type 1 secretion system. In the past decade, TRP120 has emerged as a model moonlighting effector, acting as a ligand mimetic, nucleomodulin and ubiquitin ligase. These defined functions illuminate the diverse roles TRP120 plays in exploiting and manipulating host cell processes, including cytoskeletal organization, vesicle trafficking, cell signaling, transcriptional regulation, post-translational modifications, autophagy and apoptosis. This review will focus on TRP effectors and their expanding roles in infection and provide perspective on Ehrlichia chaffeensis as an invaluable model organism for understanding infection strategies of obligately intracellular bacteria.
Social Isolation Profiles and Older Adult Substance Use: A Latent Profile Analysis
Authors: Farmer Antoinette Y , Wang Yuqi , Peterson N Andrew , Borys Suzanne , Hallcom Donald K 
Published: April 2021

Abstract

Objectives
The aim of this study was to determine substance use among older adults based upon their social isolation and loneliness profiles.

Methods
Data were derived from the New Jersey Older Adult Survey on Drug Use and Health. Latent profile analysis (LPA) was used to determine the profiles of older adults (N = 801) based on 5 dimensions of social isolation and loneliness. Logistic and generalized ordered logistic regressions were conducted to assess the relationship between the latent profiles and substance use.

Results
LPA identified 5 social isolation/loneliness profiles. The “connected and active” group had the lowest odds of cigarette use. The “alone but not lonely” group had the highest odds of cigarette use, alcohol use, and high-risk drinking. The “alone and lonely” group had the highest odds of nonmedical drug use.

Discussion
In working with older adults who are using substances, it is important to inquire about their social isolation and loneliness. Cognitive behavioral therapy for the “alone and lonely” group may be beneficial, as it has been deemed effective in reducing loneliness and enhancing social networks.
Progressive and Parallel Decline of Humoral and T-Cell Immunity in Convalescent Healthcare Workers with Asymptomatic or Mild-to-Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Authors: Casado Jose L , Vizcarra Pilar , Velasco Hector , Hammerle Johannes , McGee Amaranta , Fernandez-Escribano Marina , Vallejo Alejandro 
Published: April 2021

Abstract
We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P &lt; .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.
Anxiety and Its Association With Screening Mammography
Authors: Loving Vilert A , Aminololama-Shakeri Shadi , Leung Jessica W T 
Published: April 2021

AbstractAnxiety is often cited as a risk of screening mammography, and organizations such as the U.S. Preventive Services Task Force list anxiety as a screening-associated “harm” that should be mitigated. However, the level of mammography-related anxiety risk is difficult to assign clearly for myriad reasons, including the variability of individuals’ baseline susceptibility to anxiety, the self-reported nature of subjective anxiety states, and the multiple sources of breast cancer screening–related anxiety. In addition, anxiety measures differ between studies and psychological responses to screening mammography vary across racial and ethnic groups. Nonetheless, breast radiology practices should acknowledge the existence of mammography-associated anxiety and consider strategies to decrease it. These strategies include immediate screening interpretations, patient education efforts, and relaxation techniques.
The Bauhaus and the Business of Window Display: Moholy-Nagy’s Endeavours at Window Display in London
Authors: Meakin Kerry 
Published: April 2021

Abstract
This article reassesses the window displays created at Simpson’s, Piccadilly, from April 1936 until early 1937 by the Bauhaus master, László Moholy-Nagy. Although art historian and biographer, Krisztina Passuth, gave Moholy-Nagy the credit for bringing new display methods to Britain, my research reveals that modern methods of display were practised well before his arrival. His designs appear removed from the professional standard of British window display, which was influenced by the fundamentals taught at the Schule Reimann in Berlin during the 1920s. To understand the discrepancy between the German influence on British display and the work of an émigré Bauhaus master in Britain, I will first consider German window reform in the 1910s and its development and influence on British display from the latter half of the 1920s. Secondly, I will examine Moholy-Nagy’s period at Simpson’s and his approach to display. Thirdly, I will attempt tounderstand why Moholy-Nagy was seemingly naïve about the modern display methods used in Britain in the mid-1930s and why Simpson’s displays were so removed from the standard of display professionals. This article is part of my doctoral research on the professionalisation of window display in Britain from 1919 to 1939.
The Underlying Effects of Celiac Disease and Subsequent Implications on Deployment in the United States Army
Authors: Seidel Grayson , Kotchman Halle , Milner Erin , O’Donovan Kevin J 
Published: April 2021

ABSTRACT

Introduction
The purpose of this review is to provide an overview of the etiology, pathology, and treatments for celiac disease (CD), as well as to provide context as to how CD impacts the U.S. military.

Materials and Methods
To conduct this review, the authors surveyed recent epidemiology and immunology literature in order to provide a detailed summary of the current understanding of CD, its diagnosis, and the real-world impacts within the Department of Defense (DoD).

Results
We described the gluten proteins and both the immune response in CD. We further describe the underlying genetic risk factors and diagnosis and pathogenesis of the disease and conclude the review with a discussion of how current DoD regulations impact U.S. military readiness.

Conclusion
Celiac disease (CD) is an autoimmune disorder that results in damage to the small intestine. Ingestion of gluten in a CD patient is usually followed by villous atrophy in the small intestine, often along with other gastrointestinal symptoms. Around 1% of patients diagnosed with CD can experience complications if gluten-free diet is not followed, including intestinal lymphoma and hyposplenism. Therefore, a patient showing possible symptoms should discuss the diagnostic process with their healthcare providers to ensure adequate understanding of serological and genetic tests along with the histological examination of intestinal biopsy. Patients should seek consults with registered dietitians to structure their diets appropriately. Considering the prevalence and incidence of CD and gluten intolerances are increasing, the military should consider providing gluten-free Meals Ready-to-Eat as an option for all service members. Given the retention of service members with CD, subsequent admission of personnel with mild CD that does not affect the duties will allow the DoD access to a growing population of fully capable service members with critical technical skills who are eager to serve the USA.
Dysuria, Rebound Tenderness, and a Palpable Mass—A Ticking Time Bomb
Authors: Miklovic Tyler , Davis Philip 
Published: April 2021

ABSTRACTA 37-year-old male presented to the emergency department with the complaint of periumbilical abdominal pain, radiating to just above pubic symphysis. The patient reported that the pain was worse with urination and associated with chills and nausea. This case reports discusses the Emergency Department (ED) course and subsequent treatment of a patient found to have an infected urachal cyst, a previously asymptomatic embryological anomaly in an otherwise healthy middle-aged adult male. This is a crucial diagnosis to make in order to avoid the potential for significant morbidity and/or mortality, given the unlikely symptomatic source.
Statistics of a single sky: constrained random fields and the imprint of Bardeen potentials on galaxy clustering
Authors: Desjacques Vincent , Ginat Yonadav Barry , Reischke Robert 
Published: April 2021

ABSTRACT
We explore the implications of a single observer’s viewpoint on measurements of galaxy clustering statistics. We focus on the Bardeen potentials, which imprint characteristic scale-dependent signatures in the observed galaxy power spectrum. The existence of an observer breaks homogeneity as it singles out particular field values at her/his position, like a spontaneous symmetry breaking. As a result, spatial averaging of the data must be performed while holding the Bardeen potentials fixed at the observer’s position. In practice, this can be implemented with the formalism of constrained random fields. In the traditional Cartesian Fourier decomposition, this constraint imprints a signature in the observed galaxy power spectrum at wavenumbers comparable to the fundamental mode of the survey. This effect, which is well within the cosmic variance, is the same for all observers regardless of their local environment because differences of potential solely are observable. In a spherical Bessel Fourier decomposition, this constraint affects the monopole of the observed galaxy distribution solely, like in CMB data. As a corollary, the scale dependence of the non-Gaussian bias induced by a local primordial non-Gaussianity is not significantly affected by the observer’s viewpoint.
The evolution of Lithium: implications of a universal Spite plateau
Authors: Matteucci Francesca , Molero Marta , Aguado David S , Romano Donatella 
Published: April 2021

ABSTRACT
The cosmological 7Li problem consists in explaining why the primordial Li abundance, as predicted by the standard Big Bang nucleosynthesis theory with constraints from WMAP and Planck, is a factor of 3 larger than the Li abundance measured in the stars of the Spite plateau defined by old, warm dwarf stars of the Milky Way halo. Several explanations have been proposed to explain this difference, including various Li depletion processes as well as non-standard Big Bang nucleosynthesis, but the main question remains unanswered. In this paper, we present detailed chemical evolution models for dwarf spheroidal and ultra faint galaxies, compute the galactic evolution of 7Li abundance in these objects, and compare it with observations of similar objects. In our models, Li is mainly produced by novae and cosmic rays, and to a minor extent, by low and intermediate mass stars. We adopt the yield combination that best fits the Li abundances in the Milky Way stars. It is evident that the observations of dwarf objects define a Spite plateau, identical to that observed in the Milky Way, thus suggesting that the Spite plateau could be a universal feature and its meaning should be discussed. The predictions of our models for dwarf galaxies are obtained by assuming as Li primordial abundance either the one detected in the atmospheres of the oldest halo stars (Spite plateau; A(Li) ∼ 2.2 dex), or the one from cosmological observations (WMAP; A(Li) ∼ 2.66 dex). Finally, we discuss the implications of the universality of the Spite plateau results.
The search for ultraviolet luminous objects in GALEX data
Authors: Karpov Sergey V , Malkov Oleg Yu , Zhao Gang 
Published: April 2021

ABSTRACT
Selection of extreme objects in data from large-scale sky surveys is a powerful tool for the detection of new classes of astrophysical objects or rare stages of their evolution. The cross-matching of catalogues and analysis of the colour indices of their objects is the usual approach to this problem, which has already provided a lot of interesting results. However, the analysis of objects that are found in only one of the surveys and are absent from all others should also attract close attention, as it may lead to the discovery of both transients and objects with extreme colour values. Here we report on an initial study aimed at the detection of objects with a significant UV excess in their spectra by cross-matching of the GALEX all-sky catalogue with several other surveys in different wavelength ranges and analysing those visible in GALEX only, or with extreme UV–optical colours (ultraviolet luminous objects). We describe the methodology for such an investigation, explain the selection of surveys for this study, and show the initial results based on a search in a small fraction of the sky. We uncovered several prominent UV-only objects lacking counterparts in catalogues of longer wavelengths, and discuss their possible nature. We also detected a single source showing an extreme UV–optical colour corresponding to UV flare on a cool sdM subdwarf star. Finally, we discuss the possible populations of objects that may be revealed in a future larger-scale analysis of this kind.
Peer Mobilization and Human Immunodeficiency Virus (HIV) Partner Notification Services Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender Women in Coastal Kenya Identified a High Number of Undiagnosed HIV Infections
Authors: Dijkstra Maartje , Mohamed Khamisi , Kigoro Alex , Mumba Teresia , Mahmoud Shally , Wesonga Abdalla , Mukuria Nana , Oduor Tony , Gichuru Evans , Schim van der Loeff Maarten F , Palmer Shaun , Graham Susan M , van der Elst Elise M , Sanders Eduard J 
Published: April 2021

AbstractBackgroundHuman immunodeficiency virus (HIV) partner notification services (HPN), peer mobilization with HIV self-testing, and acute and early HIV infection (AEHI) screening among gay, bisexual, and other men who have sex with men (GBMSM) and transgender women (TGW) were assessed for acceptability, feasibility, and linkage to antiretroviral therapy (ART) and preexposure prophylaxis (PrEP) services.MethodsBetween April and August 2019, peer mobilizers mobilized clients by offering HIV oral self-tests and immediate clinic referral for clients with AEHI symptoms. Mobilized participants received clinic-based rapid antibody testing and point-of-care HIV RNA testing. Newly diagnosed participants including those derived from HIV testing services were offered immediate ART and HPN. Partners were recruited through HPN.ResultsOf 772 mobilized clients, 452 (58.5%) enrolled in the study as mobilized participants. Of these, 16 (3.5%) were HIV newly diagnosed, including 2 (0.4%) with AEHI. All but 2 (14/16 [87.5%]) initiated ART. Thirty-five GBMSM and TGW were offered HPN and 27 (77.1%) accepted it. Provider referral identified a higher proportion of partners tested (39/64 [60.9%] vs 5/14 [35.7%]) and partners with HIV (27/39 [69.2%] vs 2/5 [40.0%]) than index referral. Of 44 enrolled partners, 10 (22.7%) were newly diagnosed, including 3 (6.8%) with AEHI. All 10 (100%) initiated ART. PrEP was initiated among 24.0% (103/429) mobilized participants and 28.6% (4/14) partners without HIV.ConclusionsHPN, combined with a peer mobilization–led self-testing strategy and AEHI screening for GBMSM and TGW, appears to be acceptable and feasible. These strategies, especially HPN provider referral, effectively identified undiagnosed HIV infections and linked individuals to ART and PrEP services.
Genus 0 Gopakumar–vafa Invariants of the Banana Manifold
Authors: Morishige Nina 
Published: April 2021

Abstract
The Banana manifold $X_{Ban}$ is a compact Calabi–Yau threefold constructed as the conifold resolution of the fiber product of a generic rational elliptic surface with itself, which was first studied by Bryan. We compute Katz’s genus 0 Gopakumar–Vafa invariants of fiber curve classes on the Banana manifold $X_{Ban}\to \mathbf{P} ^1$. The weak Jacobi form of weight −2 and index 1 is the associated generating function for these genus 0 Gopakumar–Vafa invariants. The invariants are shown to be an actual count of structure sheaves of certain possibly non-reduced genus 0 curves on the universal cover of the singular fibers of $X_{Ban}\to\mathbf{P}^1$.
Aspiring for Change: Ethiopian Women’s Labor Migration to the Middle East
Authors: Schewel Kerilyn 
Published: April 2021

Abstract
This paper examines why young women in rural Ethiopia decide to migrate as domestic workers to the Middle East. Based on survey data and 84 in-depth interviews, it explores the forces shaping young women’s aspirations and capabilities to migrate, challenging the dominant narratives of trafficking, deception, and victimization that surround this migration corridor. It finds, first, that migration to the Middle East is one migration trajectory embedded within a broader urban transition occurring across Ethiopia. For rural women, labor emigration is often a long-distance, short-term strategy to access the capital needed to realize a long-term, short-distance move to town. Second, the aspiration to migrate emerges at a particular moment in the life course, as young women transition from adolescence into adulthood and when local opportunities do not provide promising pathways to achieve their life aspirations. This paper shows why labor emigration can simultaneously be a reasonable, capabilities-enhancing choice for young women and a response to a critical lack of capabilities in other domains of their lives. Finally, through applying an aspiration–capability framework, this paper advances a theoretical approach that avoids the common binary between “forced” and “voluntary” migration and thus contributes to advancing research on other forms of precarious migration occurring under highly constrained conditions.
Aerobic and resistance exercise improve patient-reported sleep quality and is associated with cardiometabolic biomarkers in Hispanic and non-Hispanic breast cancer survivors who are overweight or obese: results from a secondary analysis
Authors: Dieli-Conwright Christina M , Courneya Kerry S , Demark-Wahnefried Wendy , Sami Nathalie , Norris Mary K , Fox Frank S , Buchanan Thomas A , Spicer Darcy , Bernstein Leslie , Tripathy Debu 
Published: April 2021

AbstractStudy ObjectivesPoor sleep quality affects nearly one-third of breast cancer survivors and is associated with insulin resistance. The purpose of this secondary analysis was to examine the effects of a 16-week exercise intervention on patient-reported sleep quality among breast cancer survivors and assess whether changes in patient-reported sleep quality were associated with cardiometabolic biomarkers. We explored Hispanic ethnicity as a moderator of the effects of exercise on patient-reported sleep quality.MethodsBreast cancer survivors who were overweight or obese were randomized to exercise (n = 50) or usual care (n = 50). The 16-week intervention included aerobic and resistance exercise. Patient-reported sleep quality (Pittsburgh Sleep Quality Index [PSQI]) and biomarkers of cardiometabolic health were assessed at baseline and post-intervention. Within- and between-group differences were assessed using general linear models repeated-measures analyses of variance and mixed-model repeated-measure analysis, respectively. Associations between changes in PSQI and cardiometabolic biomarkers were computed using Pearson correlations. Linear mixed-models were used to evaluate effect modification by ethnicity.ResultsParticipants were 52 ± 10.4 years old, and over half were of Hispanic ethnicity. As compared to usual care, PSQI global scores improved significantly in the exercise group (mean between-group difference −2.2; 95% CI −3.2 to −0.6). Change in PSQI was inversely associated with changes in all cardiometabolic biomarkers (p &lt; 0.01) among the exercise group. Ethnicity was found to moderate the effects of exercise training on global sleep quality (p &lt; 0.001).ConclusionsAn aerobic and resistance exercise intervention effectively improved patient-reported sleep quality in breast cancer survivors. Hispanic ethnicity as a moderator showed greater improvement in patient-reported sleep indicating Hispanic versus non-Hispanic breast cancer survivors may derive larger sleep benefits.Clinical Trail InformationNCT01140282.
Impact of Flexible Work Arrangements on Key Challenges to Work Engagement Among Older Workers
Authors: Allen Joanne , Alpass Fiona M , Szabó Ágnes , Stephens Christine V 
Published: April 2021

Abstract
As workforces age, organizations are challenged to provide human resource management policies and practices that are responsive to the needs of older workers. Flexible work arrangements (FWAs)—practices that allow workers to influence when, where, and how work is completed—have been promoted as enabling older workers to maintain work engagement by decreasing demands of the work role, providing the autonomy to balance work and nonwork commitments, and signalling the value of workers to employers. The current study aimed to examine whether FWAs were effective in alleviating key challenges to work among older workers by assessing the impact of FWAs on the associations of physical health, mental health, and negative age-related stereotypes about older workers, with work engagement. Data were obtained from 1,834 workers aged 55–82 (age M = 63.3, 54% female) from a general random sample of older adults. Greater mental health and lower negative stereotypes predicted higher work engagement. Greater physical and mental health conveyed an indirect impact on engagement via lower perception of negative stereotypes. Greater FWAs displayed a weak negative association with the perception of negative stereotypes about older workers and reduced the association of negative stereotypes with work engagement. Access to FWAs may have a minor role in alleviating key risks to work engagement associated with mental and social challenges for an aging workforce. Considerations for future investigations of FWAs and their impact on risks to engagement among older workers are discussed.