bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calibration of ECMWF Seasonal Ensemble Precipitation Reforecasts in Java (Indonesia) Using Bias-Corrected Precipitation and Climate Indices
Authors: Ratri Dian Nur , Whan Kirien , Schmeits Maurice 
Published: May 2021

AbstractThe seasonal precipitation forecast is one of the essential inputs for economic and agricultural activities and has significant impact on decision-making. Large-scale modes of climate variability have strong relationships with seasonal rainfall in Java and are natural candidates for use as potential predictors in a statistical postprocessing application. We explore whether using climate indices as additional predictors in the statistical postprocessing of ECMWF Seasonal Forecast System 5 (SEAS5) precipitation can improve skill. We use parametric statistical postprocessing by applying a logistic distribution-based ensemble model output statistics (EMOS) technique. We add a variety of potential predictors in the analysis, namely SEAS5 raw and empirical quantile mapping (EQM) bias-corrected precipitation, Niño-3.4 index, dipole mode index (DMI), Madden–Julian oscillation (MJO) indices, sea surface temperature (SST) around Java, and several other predictors. We analyze the period of 1981–2010, focusing on July, August, September, and October. We use the continuous ranked probability skill score (CRPSS) and Brier skill score (BSS) in a comparative verification of raw, EQM, and EMOS seasonal precipitation forecasts. We have found that it is essential to use EQM-corrected precipitation as a predictor instead of raw precipitation in the latter. Besides, Niño-3.4 and DMI forecasts are not needed as extra predictors to improve monthly precipitation forecasts for the first lead month, except for September. However, for somewhat longer lead months, in September and October when there is more skill than climatology, the model that includes only Niño-3.4 and DMI forecasts as potential predictors performs about the same compared to the model that uses only EQM-corrected precipitation as a predictor.
Microsurgical Management of Early Onset Alveolar Soft Part Sarcoma of the Oral Tongue: Case Report and Review of the Literature
Authors: Lucas Jacob C. , Karadaghy Omar A. , Andrews Brian , Friedman Elizabeth , Kakarala Kiran , Przylecki Wojciech , Arganbright Jill 
Published: May 2021

Objectives: Alveolar soft part sarcoma is a rare subset of soft tissue sarcomas, typically presenting in subjects 15 to 35 years of age. Usual presentation sites are the trunk, extremities, and the head and neck. Subjects younger than 5 years are rarely affected. Methods: In this retrospective case report, we present a 16-month old male with a rapidly growing soft tissue mass of the anterior and posterior tongue, found to be alveolar soft part sarcoma. Results: The subject was treated with primary surgical resection and the resulting defect was reconstructed with a radial forearm free flap. Conclusions: To our knowledge, this is the youngest subject to have been diagnosed with alveolar soft part sarcoma. Surgical extirpation and microvascular reconstruction were successful, and the patient remains disease free 4 years post-operatively.
Échale Neurona and contextual barriers to sex and sexuality education in Mexico
Authors: Aguila Sánchez Julio C , Covarrubias Cuéllar Karla Y , Vázquez Guerrero Marina 
Published: May 2021

Background: Developing sex and sexuality education programmes for adolescents has proved challenging in many parts of the world, especially in contexts where the importance of these programmes is not valued. In such settings, educating about sex and sexuality may also require dealing with detractors who are active in spreading misinformation. Objective: This article identifies contextual barriers encountered by those involved in developing the Échale Neurona programme in Mexico. Team members associated with the programme have been teaching about sex and sexuality in public secondary and high schools since 2016. Methods and design: Grounded theory approach using semi-structured interviews. Interviews took place with 10 participants including health promotion experts and programme officials. The main focus of the interviews was on the contextual limitations encountered when implementing sex and sexuality education workshops. Results: Findings reveal at least three types of barriers hindering the comprehensive sex and sexuality education developed by the programme: institutional, cultural and socio-educational barriers. Conclusion: Contextual barriers associated with family and school environments posed a significant challenge to implementation. Such barriers may facilitate or hinder sex and sexuality education programmes affecting the way young people develop their sex lives and live their sexuality.
Parents’ Perceptions and Engagement Regarding School-Based Physical Activity Promotion
Authors: Webster Collin A. , McLoughlin Gabriella , Starrett Angie , Papa Jillian , Erwin Heather , Reed Julian A. , Carson Russell L. , Burgeson Charlene 
Published: May 2021

Purpose: This study examined parents’ perceived importance of, and engagement in, school-based physical activity (PA) promotion. Design: A cross-sectional, quantitative survey design was employed. Setting: The survey was conducted in the United States. Subjects: Using a probability-based panel (AmeriSpeak®), a national sample of 3599 parents was randomly recruited to participate in the survey and 1015 participants (28.2%) completed it. Parents or legal guardians of children enrolled in K-12 during the 2017-2018 school year were eligible to participate. Measures: The survey was developed and distributed by a national collaborative for active schools with the support of a national research center. Analysis: Data were analyzed using structural equation modeling and path analysis. Results: The data supported a 6-factor solution encompassing perceived importance of PA before, during, and after school, communication with administrators, and volunteering and participating in school-based PA (CFI = .974, RMSEA = .034, SRMR = .056). Path coefficients from perceived importance of PA before/after school to current (β = .43; 95%CI[.25, .61]) and future communication with administrators (β = .40; 95%CI[.23, .55]) were statistically significant, as were coefficients from perceived importance of PA before/after school to past (β = .60; 95%CI[.35, .83]) and current volunteering/participating in school-based PA (β = .63; 95%CI[.42, .85]). Conclusion: Parents’ perceived importance of school-based PA opportunities before and after school warrants emphasis in future research and advocacy.
Women in Agriculture
Authors: Kajale Jayanti , Shroff Sangeeta 
Published: May 2021

It is observed that while woman share half the population, the share of women among total main workers has been declining. In view of this, the article studies the trend in women workforce in the agricultural sector from 2004–2005 to 2018–2019 and discusses reasons for the declining trend, various gender related challenges faced by women workforce in agriculture and policies which may be implemented to address the same. JEL Classification: J710, J160, J210
Care consumption of people with multiple sclerosis: A multichannel sequence analysis in a population-based setting in British Columbia, Canada
Authors: Roux Jonathan , Kingwell Elaine , Zhu Feng , Tremlett Helen , Leray Emmanuelle ,   the BeAMS Study group
Published: May 2021

Background: Persons with multiple sclerosis (PwMS) typically require complex multidisciplinary care, which is rarely formally assessed. Objectives: We applied multichannel sequence analysis (MCSA) to identify care consumption patterns by PwMS in British Columbia, Canada. Methods: We created two cohorts, comprising incident and prevalent MS cases, using linked clinical and administrative data. We applied MCSA to quantify and compare the care pathways of PwMS, based on all-cause hospitalizations and physician visits (divided into five specialities). Care consumption clusters were characterized using demographic and clinical features. Results: From 1048 incident and 3180 prevalent PwMS, the MCSA identified 12 and 6 distinct care consumption clusters over a median follow-up of 9.6 and 13.0 years, respectively. Large disparities between clusters were observed; the median number of annual consultations ranged from 5.6 to 21.3 for general practitioners, 1.2 to 4.6 for neurologists and 0 to 5.3 for psychiatrists in the incident cohort. Characteristics at MS symptom onset associated with the highest care consumption included high comorbidity burden and older age. There were similar disparities and associations for prevalent PwMS. Conclusion: The distinct patterns of care consumption, which were reminiscent of the heterogeneity of MS itself, may facilitate health service planning and evaluation, and provide a novel outcome measure in health research.
Low complication rates of testosterone and estradiol implants for androgen and estrogen replacement therapy in over 1 million procedures
Authors: Donovitz Gary S. 
Published: May 2021

Background: Testosterone (T) deficiency (TD) in men and women and estrogen (E) deficiency (ED) in women increasingly affects the overall health and quality of life of patients. T implants have seen increased utilization over the past decade. We evaluated continuation rates and adverse events that occurred during T therapy by reviewing practitioner reported data on compressed human-identical T implants for the treatment of TD in both men and women collected over 7 years. Methods: This was a retrospective review of data collected prospectively from men and women from 2012 and 2019. Men who had the clinical syndrome of TD received subcutaneous T implant therapy. Women who presented with symptoms of TD and/or ED underwent T implant and/or estradiol implant therapy. The clinics spanned multiple specialties including obstetrics and gynecology, internal medicine, family practice, and urology. Data were entered into a secure, custom tracking App, using Azure App Services and MS SQL Database integrated with a proprietary dosing site and industry-leading Pharmacy Dispensing software (BioTracker®). Results: Over the 7 years, 1,204,012 subcutaneous implant procedures were performed for 376,254 patients; 85% of the procedures were performed in women. Of the women, 54% of were premenopausal, and 46% were postmenopausal. The overall continuation rate after two insertions was 93%. The overall complication rate was <1%. Most common secondary response reported was pellet extrusion, which was more common in men (<3%) than women (<1%). Conclusions: This study is the largest reported retrospective study to evaluate the continuation and complication rates of T pellet implants. The safety of subcutaneous hormone pellet implants in men and women appears to be better than other routes of administration of bioidentical hormone replacement therapy. Further investigations on short- and long-term benefits of this modality are ongoing and could expand the overall utilization of this method.
New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. XVI. Yurgensonite, K2SnTiO2(AsO4)2, the first natural tin arsenate, and the katiarsite–yurgensonite isomorphous series
Authors: Pekov Igor V. , Zubkova Natalia V. , Agakhanov Atali A. , Yapaskurt Vasiliy O. , Belakovskiy Dmitry I. , Vigasina Marina F. , Britvin Sergey N. , Turchkova Anna G. , Sidorov Evgeny G. , Pushcharovsky Dmitry Yu. 
Published: May 2021

AbstractThe new mineral yurgensonite, ideally K2SnTiO2(AsO4)2, the first natural arsenate with species-defining tin, and the continuous isomorphous series between yurgensonite and katiarsite KTiO(AsO4) are described from sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. Yurgensonite and a Sn-bearing variety of katiarsite are associated closely with one another and with badalovite, pansnerite, yurmarinite, achyrophanite, arsenatrotitanite, hatertite, khrenovite, svabite, sanidine, hematite, cassiterite, rutile and aphthitalite-group sulfates. Yurgensonite occurs as sword-shaped crystals up to 0.01 mm × 0.05 mm × 1 mm or acicular to hair-like individuals up to 1 mm long, typically forming radial aggregates up to 2 mm across. It is transparent, colourless, white or pale beige, with vitreous lustre. The mineral is brittle, cleavage was not observed. Dcalc is 3.877 g cm-3. Yurgensonite is optically biaxial (–), α = 1.764(6), β = 1.780(6), γ = 1.792(6) and 2Vmeas. is large. Chemical composition (wt.%, electron-microprobe; holotype) is: Na2O 0.51, K2O 16.27, Rb2O 0.12, Al2O3 0.26, Fe2O3 4.33, SiO2 0.29, TiO2 10.17, SnO2 22.01, P2O5 0.14, V2O5 0.19, As2O5 40.20, Sb2O5 4.88, SO3 0.28, total 99.65. The empirical formula based on 10 O apfu is (K1.92Na0.09Rb0.01)Σ2.02(Sn0.81Ti0.71Fe3+0.30Sb5+0.17Al0.03)Σ2.02(As1.945Si0.03S0.02P0.01V0.01)Σ2.015O10. Yurgensonite is orthorhombic, Pna21, a = 13.2681(6), b = 6.6209(3), c = 10.8113(5) Å, V = 949.74(7) Å3 and Z = 4. The crystal structure was solved from single-crystal X-ray diffraction data, R = 5.02%. Yurgensonite belongs to the KTP-structure type. It is a Ti,Sn-ordered analogue of katiarsite. The structure contains chains of corner-linked alternating crystallographically non-equivalent octahedra M(1) and M(2). In yurgensonite, Sn4+ prevails in the M(2)O6 octahedron whereas the M(1) site is Ti4+-dominant. The new mineral is named in honour of the Russian mineralogist, geochemist and specialist in studies of ore deposits Professor Georgiy Aleksandrovich Yurgenson (born 1935).
BTK inhibitors, irrespective of ITK inhibition, increase efficacy of a CD19/CD3-bispecific antibody in CLL
Authors: Mhibik Maissa , Gaglione Erika M. , Eik David , Kendall Ellen K. , Blackburn Amy , Keyvanfar Keyvan , Baptista Maria Joao , Ahn Inhye E. , Sun Clare , Qi Junpeng , Rader Christoph , Wiestner Adrian 
Published: May 2021

Abstract
Bruton tyrosine kinase inhibitors (BTKis) are a preferred treatment of patients with chronic lymphocytic leukemia (CLL). Indefinite therapy with BTKis, although effective, presents clinical challenges. Combination therapy can deepen responses, shorten treatment duration, and possibly prevent or overcome drug resistance. We previously reported on a CD19/CD3-bispecific antibody (bsAb) that recruits autologous T-cell cytotoxicity against CLL cells in vitro. Compared with observations with samples from treatment-naïve patients, T cells from patients being treated with ibrutinib expanded more rapidly and exerted superior cytotoxic activity in response to the bsAb. In addition to BTK, ibrutinib also inhibits interleukin-2 inducible T-cell kinase (ITK). In contrast, acalabrutinib, does not inhibit ITK. Whether ITK inhibition contributes to the observed immune effects is unknown. To better understand how BTKis modulate T-cell function and cytotoxic activity, we cultured peripheral blood mononuclear cells (PBMCs) from BTKi-naive and ibrutinib- or acalabrutinib-treated CLL patients with CD19/CD3 bsAb in vitro. T-cell expansion, activation, differentiation, and cytotoxicity were increased in PBMCs from patients on treatment with either BTKi compared with that observed for BKTi-naïve patients. BTKi therapy transcriptionally downregulated immunosuppressive effectors expressed by CLL cells, including cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and CD200. CTLA-4 blockade with ipilimumab in vitro increased the cytotoxic activity of the bsAb in BTKi-naïve but not BTKi-treated PBMCS. Taken together, BTKis enhance bsAb-induced cytotoxicity by relieving T cells of immunosuppressive restraints imposed by CLL cells. The benefit of combining bsAb immunotherapy with BTKis needs to be confirmed in clinical trials.
Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy
Authors: Itzykson Raphael , Fournier Elise , Berthon Céline , Röllig Christoph , Braun Thorsten , Marceau-Renaut Alice , Pautas Cécile , Nibourel Olivier , Lemasle Emilie , Micol Jean-Baptiste , Adès Lionel , Lebon Delphine , Malfuson Jean-Valère , Gastaud Lauris , Goursaud Laure , Raffoux Emmanuel , Wattebled Kevin-James , Rousselot Philippe , Thomas Xavier , Chantepie Sylvain , Cluzeau Thomas , Serve Hubert , Boissel Nicolas , Terré Christine , Celli-Lebras Karine , Preudhomme Claude , Thiede Christian , Dombret Hervé , Gardin Claude , Duployez Nicolas 
Published: May 2021

AbstractTo design a simple and reproducible classifier predicting the overall survival (OS) of patients with acute myeloid leukemia (AML) ≥60 years of age treated with 7 + 3, we sequenced 37 genes in 471 patients from the ALFA1200 (Acute Leukemia French Association) study (median age, 68 years). Mutation patterns and OS differed between the 84 patients with poor-risk cytogenetics and the 387 patients with good (n = 13), intermediate (n = 339), or unmeasured (n = 35) cytogenetic risk. TP53 (hazards ratio [HR], 2.49; P = .0003) and KRAS (HR, 3.60; P = .001) mutations independently worsened the OS of patients with poor-risk cytogenetics. In those without poor-risk cytogenetics, NPM1 (HR, 0.57; P = .0004), FLT3 internal tandem duplications with low (HR, 1.85; P = .0005) or high (HR, 3.51; P &lt; 10−4) allelic ratio, DNMT3A (HR, 1.86; P &lt; 10−4), NRAS (HR, 1.54; P = .019), and ASXL1 (HR, 1.89; P = .0003) mutations independently predicted OS. Combining cytogenetic risk and mutations in these 7 genes, 39.1% of patients could be assigned to a “go-go” tier with a 2-year OS of 66.1%, 7.6% to the “no-go” group (2-year OS 2.8%), and 3.3% of to the “slow-go” group (2-year OS of 39.1%; P &lt; 10−5). Across 3 independent validation cohorts, 31.2% to 37.7% and 11.2% to 13.5% of patients were assigned to the go-go and the no-go tiers, respectively, with significant differences in OS between tiers in all 3 trial cohorts (HDF [Hauts-de-France], n = 141, P = .003; and SAL [Study Alliance Leukemia], n = 46; AMLSG [AML Study Group], n = 223, both P &lt; 10−5). The ALFA decision tool is a simple, robust, and discriminant prognostic model for AML patients ≥60 years of age treated with intensive chemotherapy. This model can instruct the design of trials comparing the 7 + 3 standard of care with less intensive regimens.
miR-29a sensitizes the response of glioma cells to temozolomide by modulating the P53/MDM2 feedback loop
Authors: Chen Qiudan , Wang Weifeng , Chen Shuying , Chen Xiaotong , Lin Yong 
Published: May 2021

AbstractRecently, pivotal functions of miRNAs in regulating common tumorigenic processes and manipulating signaling pathways in brain tumors have been recognized; notably, miR‐29a is closely associated with p53 signaling, contributing to the development of glioma. However, the molecular mechanism of the interaction between miR-29a and p53 signaling is still to be revealed. Herein, a total of 30 glioma tissues and 10 non-cancerous tissues were used to investigate the expression of miR‐29a. CCK-8 assay and Transwell assay were applied to identify the effects of miR-29a altered expression on the malignant biological behaviors of glioma cells in vitro, including proliferation, apoptosis, migration and invasion. A dual-luciferase reporter assay was used to further validate the regulatory effect of p53 or miR-29a on miR-29a or MDM2, respectively, at the transcriptional level. The results showed that miR-29a expression negatively correlated with tumor grade of human gliomas; at the same time it inhibited cell proliferation, migration, and invasion and promoted apoptosis of glioma cells in vitro. Mechanistically, miR-29a expression was induced by p53, leading to aberrant expression of MDM2 targeted by miR-29a, and finally imbalanced the activity of the p53-miR-29a-MDM2 feedback loop. Moreover, miR-29a regulating p53/MDM2 signaling sensitized the response of glioma cells to temozolomide treatment. Altogether, the study demonstrated a potential molecular mechanism in the tumorigenesis of glioma, while offering a possible target for treating human glioma in the future.
LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions
Authors: Zhou Xiaozhong , Xu Wangyang , Wang Yeyang , Zhang Hui , Zhang Li , Li Chao , Yao Shun , Huang Zixiang , Huang Lishan , Luo Dixin 
Published: May 2021

Abstract
Background
Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differentiation of rat bone marrow MSCs (rMSCs); however, the regulatory mechanisms underlying hypoxia-stimulated chondrogenic differentiation remain unknown.

Methods
rMSCs were induced to undergo chondrogenic differentiation under normoxic or hypoxic conditions. Expression of lncRNA DNM3OS, miR-127-5p, and GREM2 was detected by quantitative real-time PCR. Proteoglycans were detected by Alcian blue staining. Western blot assays were performed to examine the relative levels of GREM2 and chondrogenic differentiation related proteins. Luciferase reporter assays were performed to assess the association among DNM3OS, miR-127-5p, and GREM2.

Results
MiR-127-5p levels were upregulated, while DNM3OS and GREM2 levels were downregulated in rMSCs induced to undergo chondrogenic differentiation, and those changes were attenuated by hypoxic conditions (1% O2). Further in vitro experiments revealed that downregulation of miR-127-5p reduced the production of proteoglycans and expression of chondrogenic differentiation markers (COL1A1, COL2A1, SOX9, and ACAN) and osteo/chondrogenic markers (BMP-2, p-SMAD1/2). MiR-127-5p overexpression produced the opposite results in rMSCs induced to undergo chondrogenic differentiation under hypoxic conditions. GREM2 was found to be a direct target of miR-127-5p, which was suppressed in rMSCs undergoing chondrogenic differentiation. Moreover, DNM3OS could directly bind to miR-127-5p and inhibit chondrogenic differentiation of rMSCs via regulating GREM2.

Conclusions
Our study revealed a novel molecular pathway (DNM3OS/miR-127-5p/GREM2) that may be involved in hypoxic chondrogenic differentiation.
Green and Cost-Effective Synthesis of Tin Oxide Nanoparticles: A Review on the Synthesis Methodologies, Mechanism of Formation, and Their Potential Applications
Authors: Gebreslassie Yemane Tadesse , Gebretnsae Henok Gidey 
Published: May 2021

AbstractNanotechnology has become the most promising area of research with its momentous application in all fields of science. In recent years, tin oxide has received tremendous attention due to its fascinating properties, which have been improved with the synthesis of this material in the nanometer range. Numerous physical and chemical methods are being used these days to produce tin oxide nanoparticles. However, these methods are expensive, require high energy, and also utilize various toxic chemicals during the synthesis. The increased concerns related to human health and environmental impact have led to the development of a cost-effective and environmentally benign process for its production. Recently, tin oxide nanoparticles have been successfully synthesized by green methods using different biological entities such as plant extract, bacteria, and natural biomolecules. However, industrial-scale production using green synthesis approaches remains a challenge due to the complexity of the biological substrates that poses a difficulty to the elucidations of the reactions and mechanism of formations that occur during the synthesis. Hence, the present review summarizes the different sources of biological entities and methodologies used for the green synthesis of tin oxide nanoparticles and the impact on their properties. This work also describes the advances in the understanding of the mechanism of formation reported in the literature and the different analytical techniques used for characterizing these nanoparticles.