bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bismuth‐Based Materials for Supercapacitor Application
Authors: Tripathi Babita , Gujjar Surajbhan , Yahya M. Z. A. , Noor I. M. , Singh Ram Chandra 
Published: February 2025

AbstractThe demand for supercapacitors is highly increasing in the area of energy storage devices. In the last decade, researchers have explored such types of electrode materials, which contain high energy density, are electrochemically stable, are eco‐friendly, and are economically usable. Various research has been based on metal‐based nanocomposites, among which bismuth‐based nanocomposites are highly recommended due to their multiferroic redox characteristics, charge‐storage capacity, and nontoxic behavior. In this research communication, the authors discuss the importance of bismuth‐based materials in the area of energy storage devices, the types of bismuth nanocomposite for supercapacitor applications, and their future scope in the area of energy storage applications.
Etlingera elatior‐Mediated Green Synthesis Titanium Dioxide Nanoparticles and Its Cytotoxicity
Authors: Norman Ashreen , Abdellatief Mahmoud , Ghourani Ala’ Al , Cordova Kyle E , Borikul Nidchakan , Fang Teh Huey , Abdullah Che Azurahanim Che 
Published: February 2025

AbstractThis work looks at the ecologically friendly synthesis of titanium dioxide nanoparticles (TiO2NPs) using Etlingera elatior (EE) and how various calcination temperatures affect their structure. X‐ray diffraction (XRD) analysis indicate that the green TiO2NPs' crystallite diameters range from 140.12 to 143.46 nm. Due to the limits of conventional XRD, the green TiO2NPs are further characterised using synchrotron XRD (SXRD). SXRD analysis reveals that when calcination temperatures rise, crystallite size gradually increases, and rutile phase formation occurs. Hydrodynamic processes cause bigger particle sizes in dynamic light scattering (DLS). The absorbance spectra of green TiO2NPs are found to be between 205 and 208 nm. Fourier transform infrared (FTIR) spectroscopy validate the chemical structures of the TiO2NPs present. The Raman analysis confirm the existence of both anatase and rutile phases, which are visible in SXRD. Thermogravimetric analysis (TGA) reveals that owing to high calcination temperatures, thermal degradation is minimal due to organic component loss during the calcination process. Further examination into its environmental toxicity demonstrated that green TiO2NPs are less harmful than commercialised P25 titania in a brine shrimp lethality assay. The study's findings show that green synthesis is environmentally safe. Aside from that, calcination for green TiO2NPs is unnecessary in future work as it increases particle size as shown in SXRD.
Synthesis, Characterization, and Study of Biological, Laser, Nanoscale, Cancer, and Molecular Docking Activity of Tetrazole Compounds Derived from 1,3,4‐Oxadiazole
Authors: Mahdi Saleh Maha , Hamid Juma Fawzi 
Published: February 2025

AbstractThis study involves the synthesis of pentagonal rings of tetrazole derivatives through the reaction of one mole of hydrazide base derivatives with two moles of sodium azide. The validity of the compound structures is confirmed using physical and spectroscopic methods such as UV‐Vis, FTIR, proton, and carbon NMR, as well as elemental analysis. Additionally, melting points and purity are determined, and reaction progress is monitored by thin‐layer chromatography (TLC). Nanocompounds are prepared by synthesizing silver nanoparticles using fig leaf extract, followed by their addition to the prepared compounds. Characterization is conducted through X‐ray diffraction (XRD), Scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The impact of some prepared compounds on the growth of two bacterial isolates, one Gram‐negative (Escherichia coli) and the other Gram‐positive (Staphylococcus aureus), is studied. Antibiotics amoxicillin, ampicillin, and ciprofloxacin are used as controls, and some of the prepared compounds show good inhibitory effectiveness against the tested bacteria. Moreover, a qualitative evaluation of antioxidant activity, assessed by the scavenging of free radicals using TLC, is performed to determine the ability of compounds (M8) to reduce oxidative stress. The prepared compound (M8) is tested for its ability to inhibit the growth of human breast cancer cells (MCF‐7) outside the living organism. Molecular docking studies of some prepared compounds on two targets, breast cancer and E. coli bacteria, are conducted using MOE (2009). Energy minimization of the compounds is carried out to obtain the most stable conformation with the lowest energy barrier.
Removal of Methylene Blue by Degradation Using Polysulfone–Boehmite–Graphene Oxide Microfiber Photocatalyst Under Visible and Solar Lights
Authors: Mahmood Ahmed R. , Mohammed Nabeel Shaheen , Ali Jassim Mohammed , Alheety Mustafa A. 
Published: February 2025

AbstractBoehmite–graphene oxide nanocomposite is prepared by electrochemical method via the reaction of graphene oxide (GO) within the electrochemical cell that contain aluminum alloy as electrodes. The resulted nanocomposite (B–GO) is mixed with polysulfone (PS) and electrospun to prepare polysulfone–boehmite–graphene oxide microfiber that is characterized by XRD and SEM. This microfiber is used to examine it efficiency in the degradation of methylene blue (MB, 100 ppm) under visible (500‐W lamp) and solar lights. The optimal conditions (pH, dosage of B–GO, time, temperature) are studied, and the result show that the nanofibers are able to degrade more than 80% of MB under visible light and more than 99% under solar light.
Histidine triad nucleotide‐binding protein 2 attenuates doxorubicin‐induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice
Authors: Jiang Hao , Zhang Jinyan , Jia Daile , Liu Liwei , Gao Jinfeng , Zhang Beijian , Dong Zhen , Sun Xiaolei , Yang Wenlong , Ou Tiantong , Ding Suling , He Luna , Shi Yiqin , Hu Kai , Sun Aijun , Ge Junbo 
Published: February 2025

AbstractDoxorubicin (DOX) is an effective chemotherapy drug widely used against various cancers but is limited by severe cardiotoxicity. Mitochondria–lysosome interactions are crucial for cellular homeostasis. This study investigates the role of histidine triad nucleotide‐binding protein 2 (HINT2) in DOX‐induced cardiotoxicity (DIC). We found that HINT2 expression was significantly upregulated in the hearts of DOX‐treated mice. Cardiac‐specific Hint2 knockout mice exhibited significantly worse cardiac dysfunction, impaired autophagic flux, and lysosomal dysfunction after DOX treatment. Mechanistically, HINT2 deficiency reduced oxidative phosphorylation complex I activity and disrupted the nicotinamide adenine dinucleotide NAD+/NADH ratio, impairing lysosomal function. Further, HINT2 deficiency suppressed sterol regulatory element binding protein 2 activity, downregulating transcription factor A mitochondrial, a critical regulator of complex I. Nicotinamide mononucleotide (NMN) supplementation restored lysosomal function in vitro, while cardiac‐specific Hint2 overexpression using adeno‐associated virus 9 or adenovirus alleviated DIC both in vivo and in vitro. These findings highlight HINT2 as a key cardioprotective factor that mitigates DIC by restoring the NAD+/NADH ratio, lysosomal function, and autophagy. Therapeutic strategies enhancing HINT2 expression or supplementing NMN may reduce cardiac damage and heart failure caused by DOX.
Phase I clinical trial to assess safety and efficacy of Oraxol, a novel oral paclitaxel chemotherapy agent, in patients with previously treated metastatic breast cancer
Authors: Yu Yunfang , Wang Ying , Mao Luhui , Ye Suiwen , Lai Xiuping , Chen Junyi , Zhang Yiwen , Liu Jieqiong , Wu Junyan , Qin Tao , Yao Herui 
Published: February 2025

AbstractOraxol, a novel oral paclitaxel chemotherapy agent, has emerged as a potential alternative for treating metastatic breast cancer (MBC). However, its safety and efficacy remain uncertain due to insufficient evidence supporting it. This open‐label, single‐arm, phase I trial was designed to assess the pharmacokinetics, safety, and preliminary antitumor activity of Oraxol in previously treated MBC. The primary objective was to investigate the pharmacokinetics of Oraxol, while secondary endpoints included assessing safety, tolerability, and antitumor activity. Twenty‐four patients (median age, 53 years) were enrolled, and pharmacokinetic analysis showed consistent and reproducible absorption of Oraxol. Note that 96% patients experienced treatment‐related adverse events (TRAEs) and no deaths attributed to TRAEs. The overall response rate was 34.8%, including 34.8% achieving partial response and 56.5% having stable disease. The median follow‐up was 45.7 months, with median progression‐free survival (PFS) of 3.41 months and median overall survival of 17.80 months. Notably, among patients with triple‐negative breast cancer, the disease control rate was 100%, and the median PFS was 8.90 months, which notably exceeded the outcomes observed in other subtypes. Oraxol significantly alters metabolism and correlates with response and survival. In conclusion, Oraxol exhibited promising antitumor efficacy and manageable safety profiles in MBC patients.
Low versus high peripheral oxygen saturation directed oxygen therapy in critically ill patients: a multicenter randomized controlled trial
Authors: Yang Xiaobo , Gao Xuehui , Zheng Xiang , Zhao Xu , Liu Yanli , Zhang Lu , Sun Junli , Wang Peng , Xu Zhengqin , Hu Ronghua , Li Hongbin , Qi Hong , Yuan Yin , Chen Wei , Liu Jie , Huang Guangqing , Yu Li , Cao Fengsheng , Xin Keke , Yu Min , Liu Xiaoyun , Zhang Li , Chang Siyuan , Zou Xiaojing , Liu Hong , Fu Zhaohui , Shu Huaqing , Yu Yuan , Xu Jiqian , Yuan Shiying , Shang You 
Published: February 2025

AbstractWhether low peripheral oxygen saturation (SpO2) directed oxygen therapy is associated with lower mortality in critically ill patients needs further exploration. Adult critically ill patients from 11 intensive care units in China were screened. Participants were randomly assigned to the low SpO2 (90%–95%) group or the high SpO2 (≥96%) ‐group. The primary outcome was 28‐day all‐cause mortality. The secondary outcomes were hours free from ventilators and from renal replacement therapy (RRT) within 14 days. Note that 857 patients in the low SpO2 group and 849 in the high SpO2 group were included. In the low SpO2 group versus the high SpO2 group, the time‐weighted average of the fraction of inspired oxygen (FiO2) was significantly lower (33.5 ± 9.7% vs. 39.6 ± 9.3%, p < 0.001), and so was the time‐weighted average of SpO2 (95.9 ± 1.8% vs. 98.0 ± 1.9%, p < 0.001). Within 28 days after randomization, 172 (20.1%) in the low SpO2 group and 193 (22.7%) in the high SpO2 group died (p = 0.180). Ventilator‐free time and RRT‐free time were not significantly different within 14 days. In critically ill patients, low SpO2directed oxygen therapy did not decrease 28‐day mortality, 14‐day ventilator‐free time, or 14‐day RRT‐free time.
Controlled release of MIF siRNA and GDNF protein from a photocurable scaffold efficiently repairs spinal cord injury
Authors: Gao Yan , Wang Kaiyu , Wu Yi , Wu Shan , Ma Pingchuan , Zhang Jin , Li Jingmei , Shen Guobo , Men Ke 
Published: February 2025

AbstractCompared with traditional treatment strategies, siRNA‐based gene therapy combines with protein therapy to offer a new strategy for spinal cord injury (SCI). The siRNA and protein therapy are limited by the large and deep lesion site and local co‐delivery vectors. However, the photocurable scaffold has the properties of injectable, flexible, and biodegradable, which provide a potential formulation for siRNA and protein combined therapy. Here, a photocurable lipid nanoparticle gel (PLNG) scaffold is designed for efficiently sustained and controlled release of the macrophage migration‐inhibitory factor (MIF) targeted siRNA and co‐delivery of GDNF protein for SCI. The GDNF is chemically modified in the scaffold and the prepared GDNF‐PLNG/siRNA scaffold is injectable with easily photocured. This formulation can inhibit inflammation by promoting macrophage M2 polarization and effectively promote primary neuron axon growth. After locally administered with GDNF‐PLNG/siMIF scaffold to SCI mice, the scaffold promoted neuron regeneration by upregulation of neuron cytokine production and inhibited inflammation through the downregulation immune pathway. With the interaction mechanism of GDNF and MIF siRNA, GDNF‐PLNG/siMIF scaffold increases the collagen and integrin expression to promote spinal cord repairing and significantly improve motor function, so that scaffold is a potential candidate gene formulation applied to clinical SCI treatment.
The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency
Authors: Gao Hui , Cao Xi‐Xia , Hua Hua , Zhu Hui 
Published: February 2025

ABSTRACTBackgroundPremature ovarian insufficiency (POI) is a condition in women characterized by the premature decline of ovarian function before age 40, evident through menstrual irregularities such as amenorrhea or oligomenorrhea, elevated FSH levels exceeding 25 U/L, and a progressive decrease in estrogen levels. Despite considerable research, the exact pathogenic mechanisms underlying POI remain unclear. This study focuses on the role of microRNAs (miRNAs) in the development of POI. As critical regulators of gene expression, miRNAs may play significant roles in diagnosis and the development of innovative therapeutic approaches for POI.MethodsA comprehensive literature search was conducted on PubMed for this review. We included studies published in English up to September 2024. Our search utilized a combination of the following keywords: microRNA, premature ovarian insufficiency (POI), and premature ovarian failure (POF). Articles were filtered by title and subsequently through full‐text review, selecting only those pertinent to our topics of interest and their related areas.ResultsmiRNAs have emerged as critical regulators in POI, mediating a range of biological processes that contribute to the disease's progression. Their involvement offers promising insights for early diagnosis, prognostic assessments, and therapeutic interventions, highlighting their potential as biomarkers and therapeutic targets.ConclusionElucidating miRNAs' roles in POI opens new avenues for managing the disease. By understanding how miRNAs influence the molecular mechanisms of POI, innovative strategies can be developed for diagnosis and treatment, potentially improving patient outcomes.
Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention
Authors: Tang Lin , Peng Shao‐Cong , Zhuang Xiao‐Wan , He Yan , Song Yu‐Xiang , Nie Hao , Zheng Can‐Can , Pan Zhen‐Yu , Lam Alfred King‐Yin , He Ming‐Liang , Shi Xing‐Yuan , Li Bin , Xu Wen Wen 
Published: February 2025

ABSTRACTMetastasis remains a leading cause of cancer‐related deaths, defined by a complex, multi‐step process in which tumor cells spread and form secondary growths in distant tissues. Despite substantial progress in understanding metastasis, the molecular mechanisms driving this process and the development of effective therapies remain incompletely understood. Elucidating the molecular pathways governing metastasis is essential for the discovery of innovative therapeutic targets. The rapid advancements in sequencing technologies and the expansion of biological databases have significantly deepened our understanding of the molecular drivers of metastasis and associated drug resistance. This review focuses on the molecular drivers of metastasis, particularly the roles of genetic mutations, epigenetic changes, and post‐translational modifications in metastasis progression. We also examine how the tumor microenvironment influences metastatic behavior and explore emerging therapeutic strategies, including targeted therapies and immunotherapies. Finally, we discuss future research directions, stressing the importance of novel treatment approaches and personalized strategies to overcome metastasis and improve patient outcomes. By integrating contemporary insights into the molecular basis of metastasis and therapeutic innovation, this review provides a comprehensive framework to guide future research and clinical advancements in metastatic cancer.
An Exact‐Arithmetic Algorithm for Spanning Tree Modulus
Authors: Albin Nathan , Kottegoda Kapila , Poggi‐Corradini Pietro 
Published: February 2025

ABSTRACTSpanning tree modulus is a generalization of effective resistance that is closely related to graph strength and fractional arboricity. The optimal edge density associated with the spanning tree modulus is known to produce two hierarchical decompositions of arbitrary graphs, one based on strength and the other on arboricity. Here we introduce an exact‐arithmetic algorithm for spanning tree modulus and the strength‐based decomposition using Cunningham's algorithm for graph vulnerability. The algorithm exploits an interesting connection between the spanning tree modulus and critical edge sets from the vulnerability problem. This paper introduces the new algorithm, describes a practical means for implementing it using integer arithmetic, and presents some examples and computational time scaling tests.
Speeding Up the Solution of the Site and Power Assignment Problem in Wireless Networks
Authors: Avella Pasquale , Calamita Alice , Palagi Laura 
Published: February 2025

ABSTRACTThis paper addresses the optimal design of wireless networks through the site and power assignment problem. Given a set of candidate transmitters, this problem involves choosing optimal transmitter locations and powers to provide service coverage over a target area. In the modern context of increasing traffic, establishing suitable locations and power emissions for the transmitters in wireless networks is a relevant and challenging task due to heavy radio spectrum congestion. Traditional network design formulations are very ill‐conditioned and suffer from numerical inaccuracies and limited applicability to large‐scale practical scenarios. Our contribution consists of speeding up the solution of the problem under consideration by addressing its drawbacks from a modeling point of view. We propose valid cutting planes and various presolve operations to reduce the problem size and strengthen existing formulations, along with a reduction scheme based on reduced cost fixing to reduce the sources of numerical inaccuracies. Our proposals prove effective, allowing us to achieve optimality on large‐scale instances obtained from a real 4G LTE network in solution times aligning well with planning windows.
Mechanical characteristics of 3D‐printed honeycomb sandwich structures: Effect of skin material and core orientation
Authors: Mirzaei Jaber , Niyaraki Meysam Nouri , Nikouei Sayed Mohamad 
Published: February 2025

AbstractSandwich structures are crucial in automotive, and construction industries due to their lightweight, high‐strength properties, insulation, and energy absorption capabilities. In addition, 3D‐printed sandwich structures are important due to their customizable geometry and controlled material distribution, which enhance strength and stiffness. This study examines the mechanical properties of composite sandwich structures with a 3D‐printed honeycomb core. The composite skin, fabricated using the wet hand lay‐up method, consists of glass, carbon, and epoxy resin, while a fused deposition modeling machine produces the polylactic acid (PLA+) honeycomb core. A full factorial design and analysis of variance were employed to evaluate the effects of skin material and core orientation on mechanical properties through compression and three‐point bending tests. The mechanical performance of sandwich structures improved through core‐skin synergy, enhancing load distribution and resistance. Carbon/epoxy skins offered stiffness and strength, delaying failure modes, while glass/epoxy provides flexibility and cost‐efficiency. Hybrid skins combined these benefits, enhancing stability. In addition, vertical core orientation further maximized load capacity and minimized buckling compared to horizontal alignment. Optical analysis revealed buckling and crack propagation as primary failure mechanisms. Last but not least, finite element analysis using ABAQUS confirmed qualitative similarity in load–displacement curves and deformation behavior with experimental results.Highlights
Mechanical properties of 3D‐printed sandwich structures were analyzed via the design of experiment.
Vertical core orientation improves compressive and flexural properties over horizontal cores.
Carbon/epoxy skins deliver superior flexural and compressive strength in sandwich panels.
Failure mechanisms include core buckling, cell wall debonding, and skin wrinkling/cracking.
Finite element analysis results closely aligned with experimental tests, validating structural behavior predictions.
Assessment of geometric parameters on the tensile behavior of hybrid (rivet‐adhesive) aluminum‐composite joints
Authors: Nourmohammadi Alireza , Behjat Bashir , Mobayyen Mir Amir 
Published: February 2025

AbstractThe hybrid adhesive‐rivet joints offer very good behavior in bonding. This bond is then reinforced by a rivet, adding significant mechanical strength and preventing separation under stress. In this research, composite‐aluminum, hybrid (adhesive‐rivet) joints were investigated. Two types of composites were used in this research: unidirectional and woven fiber types. Hybrid (adhesive‐rivet) joints made in two distinct types: single and double rivet joints. Various types of simple and hybrid (rivet adhesive) joint with one or two rivets are investigated and effect of them on strength of various composite substrate are investigated. The study advances knowledge by demonstrating how combining adhesive and rivet reinforcements optimizes joint strength and energy absorption in composite‐aluminum structures. It was observed that adhesive joint specimens of Al–glass fiber reinforced plastic (GFRP) with a 45‐degree unidirectional fiber angle (Al–CU—45) have the lowest strength than 0° and 90° UD fiber angles (Al–CU—0 and 90) and the tensile strength of hybrid adhesive joints for woven GFRP composites (Al–CW) is better than joints with 45‐degree woven GFRP composites. Two‐rivet joints with 0°/90° fibers exhibited 30% higher load capacity than ±45° fibers, while also absorbing 20% more energy compared to single‐rivet joints. The maximum fracture force in the single‐rivet specimen with 0° fiber orientation has improved by 42.8% compared to the single‐rivet specimen with 90° fiber orientation. Finally, fractography of specimens were done and macroscopic and microscopic investigation of fracture surface of samples are done. The scanning electron microscopy images shows detailed view of the fracture surfaces and effect of rivets on the surface of fracture.Highlights
Adhesive joints: 0°/90° GFRP outperformed 45° fibers in tensile strength.
Fracture force: Al–CU‐0° fibers showed the highest force in hybrid joints.
Displacement: Al–CU‐45° fibers had the highest failure displacement.
Energy absorption: Al–CU‐45° fibers excelled in both adhesive and hybrid joints.
SEM: 0/90° fibers showed fewer cracks, while 45° fibers had weaker matrices.