bluuebunny/crossref_metadata_2025_split huggingface dataset:
PİYASA VOLATİLİTESİNİN KONUT KREDİ HACMİNE ETKİSİ: TÜRK BANKACILIK SEKTÖRÜNE İLİŞKİN BİR UYGULAMA
Authors: KOÇ İlker , BUMİN Mete , DEMİR Yaşam 
Published: July 2021

Türkiye konut finansmanı piyasasının en önemli kaynağı olan konut kredileri son yıllarda büyük gelişim
göstermiştir. Konut kredilerinin gelişimini etkileyen en önemli değişken ise konut kredisi maliyeti olan kredi
faiz oranlarıdır. Diğer taraftan, faiz oranı düzeyinden bağımsız olarak konut kredisi hacmi ile faiz oranı volatilitesi
arasında bir ilişkinin varlığı söz konusudur. Bu çalışmada, Türk bankacılık sektöründe kullandırılan konut
kredisi hacmi ile faiz oranı volatilitesi arasındaki ilişkinin ekonometrik yöntemlerle analiz edilmesi hedeflenmiştir.
Bu amaçla, “Üç Aşamalı En Küçük Kareler” (ÜAEEK) yöntemi ile tahmin edilen eşanlı denklem modeli
esas alınmıştır. Bu çalışma ile Türk bankacılık sektöründeki konut kredilerinin piyasa faiz oranı volatilitesi ile
ilişkisi incelenerek bu alanda literatürdeki eksikliğin giderilmesine katkı sağlanması hedeflenmektedir. Modelde
yer alan ve genel olarak durağan olmayan konut kredisi, gelir, enflasyon ve faiz oranı volatilitesi zaman serilerinin
ÜAEEK yöntemi tahmini için uzun dönemli eşbütünleşme yaklaşımından faydalanmıştır. Analiz sonucunda,
piyasa volatilitesinin konut kredisi hacmi üzerinde önemli bir etkisi olduğu bulgusuna ulaşılmıştır. Ayrıca,
bu durumun faiz oranlarının genel olarak negatif eğilimli olduğu dönemlerde tasarruf sahiplerinin daha
yüksek getirili araçlara yönelmesinden kaynaklanmış olabileceği değerlendirilmiştir.
The B-topology onS∗-doubly quasicontinuous posets
Authors: Sun Tao , Li Qingguo , Zou Zhiwei 
Published: July 2021

AbstractThe notions ofos{o}_{s}-convergence andS∗{S}^{\ast }-doubly quasicontinuous posets are introduced, which can be viewed as common generalizations of Birkhoff’s order-convergence andS∗{S}^{\ast }-doubly continuous posets, respectively. We first consider the relationship betweenos{o}_{s}-convergence and B-topology and show that the topology induced byos{o}_{s}-convergence according to the standard topological approach is the B-topology precisely. Then, the topological characterization for theS∗{S}^{\ast }-doubly quasicontinuity is presented. It is proved that a poset isS∗{S}^{\ast }-doubly quasicontinuous iff the poset equipped with the B-topology is locally hyperclosed iff the lattice of all B-open subsets of the poset is hypercontinuous. Finally, the order theoretical condition for theos{o}_{s}-convergence being topological is given and the complete regularity of B-topology onS∗{S}^{\ast }-doubly quasicontinuous posets is explored.
Characterization of Seizure Induction Methods inDrosophila
Authors: Mituzaite Jurga , Petersen Rasmus , Claridge-Chang Adam , Baines Richard A. 
Published: July 2021

AbstractEpilepsy is one of the most common neurologic disorders. Around one third of patients do not respond to current medications. This lack of treatment indicates a need for better understanding of the underlying mechanisms and, importantly, the identification of novel targets for drug manipulation. The fruit flyDrosophila melanogasterhas a fast reproduction time, powerful genetics, and facilitates large sample sizes, making it a strong model of seizure mechanisms. To better understand behavioral and physiological phenotypes across major fly seizure genotypes we systematically measured seizure severity and secondary behavioral phenotypes at both the larval and adult stage. Comparison of several seizure-induction methods; specifically electrical, mechanical and heat induction, show that larval electroshock is the most effective at inducing seizures across a wide range of seizure-prone mutants tested. Locomotion in adults and larvae was found to be non-predictive of seizure susceptibility. Recording activity in identified larval motor neurons revealed variations in action potential (AP) patterns, across different genotypes, but these patterns did not correlate with seizure susceptibility. To conclude, while there is wide variation in mechanical induction, heat induction, and secondary phenotypes, electroshock is the most consistent method of seizure induction across known major seizure genotypes inDrosophila.
A study of the COVID‐19 epidemic in India using the SEIRD model
Authors: Banerjee Rudra , Bhattacharjee Srijit , Varadwaj Pritish Kumar 
Published: July 2021

BackgroundThe coronavirus pandemic (COVID‐19) is causing a havoc globally, exacerbated by the newly discovered SARS‐CoV‐2 virus. Due to its high population density, India is one of the most badly effected countries from the first wave of COVID‐19. Therefore, it is extremely necessary to accurately predict the state‐wise and overall dynamics of COVID‐19 to get the effective and efficient organization of resources across India.MethodsIn this study, the dynamics of COVID‐19 in India and several of its selected states with different demographic structures were analyzed using the SEIRD epidemiological model. The basic reproductive ratio R0 was systemically estimated to predict the dynamics of the temporal progression of COVID‐19 in India and eight of its states, Andhra Pradesh, Chhattisgarh, Delhi, Gujarat, Madhya Pradesh, Maharashtra, Tamil Nadu, and Uttar Pradesh.ResultsFor India, the SEIRD model calculations show that the peak of infection is expected to appear around the middle of October, 2020. Furthermore, we compared the model scenario to a Gauss
ian fit of the daily infected cases and obtained similar results. The early imposition of a nation‐wide lockdown has reduced the number of infected cases but delayed the appearance of the infection peak significantly.ConclusionAfter comparing our calculations using India’s data to the real life dynamics observed in Italy and Russia, we can conclude that the SEIRD model can predict the dynamics of COVID‐19 with sufficient accuracy.
Phase separation in synthetic biology
Authors: Shuyu Shi , Wen Si , Xiaoyi Ouyang , Ping Wei 
Published: July 2021

BackgroundThe concept of phase separation has been used to describe and interpret physicochemical phenomena in biological systems for decades. Many intracellular macromolecules undergo phase separation, where it plays important roles in gene regulation, cellular signaling, metabolic reactions and so on, due to its unique dynamic properties and biological effects. As the noticeable importance of phase separation, pioneer researchers have explored the possibility to introduce the synthetically engineered phase separation for applicable cell function.ResultsIn this article, we illustrated the application value of phase separation in synthetic biology. We described main states of phase separation in detail, summarized some ways to implement synthetic condensates and several methods to regulate phase separation, and provided a substantial amount of identical examples to illuminate the applications and perspectives of phase separation in synthetic biology.ConclusionsMultivalent interactions implement phase separation in synthetic biology. Small molecules, light control and spontaneous interactions induce and regulate phase separation. The sy
nthetic condensates are widely used in signal amplifications, designer orthogonally non‐membrane‐bound organelles, metabolic pathways, gene regulations, signaling transductions and controllable platforms. Studies on quantitative analysis, more standardized modules and precise spatiotemporal control of synthetic phase separation may promote the further development of this field.
High‐throughput experimental methods for investigating biomolecular condensates
Authors: Chen Taoyu , Lei Qi , Shi Minglei , Li Tingting 
Published: July 2021

BackgroundThe concept of biomolecular condensate was put forward recently to emphasize the ability of certain cellular compartments to concentrate molecules and comprise proteins and nucleic acids with specific biological functions, from ribosome genesis to RNA splicing. Due to their unique role in biological processes, it is crucial to investigate their compositions, which is a primary determinant of condensate properties.ResultsSince a wide range of macromolecules comprise biomolecular condensates, it is necessary for researchers to investigate them using high‐throughput methodologies while low‐throughput experiments are not efficient enough. These high‐throughput methods usually purify interacting protein libraries from condensates before being scanned in mass spectrometry. It is possible to extract organelles as a whole for specific condensates for further analysis, however, most condensates do not have a distinguishable marker or are sensitive to shear force to be extracted as a whole. Affinity tagging allows a comprehensive view of interacting proteins of target molecule yet only proteins with strong bonds may be pulled down. Proximity labeling serves as a complementary method to label more dynamic proteins with weaker interactions, increasing sensitivity while decreasing specificity. Image‐based fluorescent screening takes another path by scanning images automatically to illustrate the condensing state of biomolecules within membraneless organelles, which is a unique feature unlike the previous mass spectrometry‐based methods.ConclusionThis review presents a rough glimpse into high‐throughput methodologies for biomolecular condensate investigation to encourage usage of bioinformatic tools by researchers in relevant fields.
Design method for the ‘impression pile’
Authors: Lalicata Leonardo Maria , Stallebrass Sarah Elizabeth , McNamara Andrew , Panchal Jignasha Prakash 
Published: July 2021

Urban development in congested cities requires a better exploitation of the available surface, leading to taller structures. These buildings are usually founded on piles that have to be increased in dimension to accommodate the larger loads, resulting in increases in both the cost and the carbon dioxide footprint of the pile foundation. An alternative option is to improve pile performance by enhancing the shaft capacity, which is commonly the most important factor in determining the ultimate capacity of a pile constructed in a clay soil subjected to axial load. For piles in stiff clays such as London Clay, the soil–pile friction may be increased by profiling the side walls of a bored cast in situ pile with small discrete ‘impressions’ such that the latter form nodules on the shaft of the concreted pile. Centrifuge tests carried out at City, University of London, and field trials undertaken by Keltbray Piling across different London sites showed an increase in the shaft capacity of around 40%. In this work, a simple design method based on experimental evidence and an existing plastic failure mechanism was derived for ‘impression’ piles. The proposed method shows good agreement with data and enables a direct prediction of the increase in capacity for future designs.
Cephe Tasarımında Sembolizm ve İsmailiye Sarayı Cephesindeki Değişim Süreci
Authors: ERTEN BİLGİÇ Didem , TAHİRLİ Zeyneb 
Published: July 2021

Sembolizm hayatın bütün alanlarında, özellikle mimaride sıkça kullanılmaktadır. Çalışmada bir yapının en önemli bölümlerinden olan cephe tasarımı üzerinde sembolizm kavramının kullanımı anlatılmaktadır. Azerbaycan’ın başkenti Bakü’de bulunan önemli yapılardan İsmailiye Sarayı’nın eski ve restorasyon sonrası yeni cephesinin değişim sürecindeki siyasal ve dini etkiler ile sembolizm arasındaki ilişki incelenmektedir. Çalışmanın amacı, İsmailiye Sarayı üzerinden cephe tasarımında uygulanmış sembolizmin izlerini örnekler göstererek tahlil etmektir. Bu bağlamda sembolizmin cephe tasarımındaki yansımalarının mimari tasarım üzerindeki etkisinin örneklerde gösterilmesi hedeflenmektedir.
1908-1913 yıllarında Musa Nağıyev tarafından yapılmış olan bu saray, çeşitli zamanlarda tarihi olaylara şahitlik etmiştir. 1918 Mart olayları sırasında Ermeniler tarafından yağmalanan ve ateşe verilen bina neredeyse tamamen yok edilmiştir. Birkaç sene sonra SSCB binayı yıkma kararı alsa da yerel halkın itirazı nedeniyle binanın restorasyonuna başlanılmıştır. Binayı restore eden Sovyet iktidarı her zaman olduğu gibi yine bu sarayda da kendi izlerini bırakarak değişiklikler yapmıştır.
Yapılan çalışmada yapının yangından önceki durumuyla yangından sonraki durumu karşılaştırılarak nicel bilimsel araştırma yöntemlerinden nedensel-karşılaştırma yöntemi kullanılarak incelenmiştir. Bu makale, Azerbaycan mimarisinde önemli yeri olan İsmailiye Binası’nın cephesinin siyasal, dini etkenler ile tarihsel süreçte nasıl değiştiğini karşılaştırmalı çizim ve resimlerle ortaya koyması açısından önem arz etmektedir. Çalışmanın sonucunda mimaride sembolizmin ne kadar etkili olduğunu görmek mümkündür
Quality of root canal treatment performed by undergraduate students at the Wits Oral Health Centre
Authors: Patel Ebrahim , Ehbesh A Alaali M , Munshi Ismail E , Tootla Saidah 
Published: July 2021

In 2012, the School of Oral Health Sciences at the University of the Witwatersrand modified its undergraduateendodontic curriculum which led to a need to assess the impact of curriculum changes on root canal treatmentoutcomes. This study was an audit of root canal treatment performed by undergraduate BDS students using postoperative radiographs, and compared the results between different undergraduate clinical years of study.Postoperative periapical radiographs of patients treated by undergraduate students were examined to assess length, density and taper. Two independent investigators were first calibrated, and thereafter assessed 299 endodontic cases that were performed by third, fourth and fifth year students during the 2013-2015 period at the Wits Oral Health Centre. 68.9%, 73.6% and 70.9% were found for adequate length, acceptable density and acceptable taper of root filling respectively. The most acceptable length, density and taper results were seen in patients treated by final year students, while the lowest results were observed in the fourth year student cohort. There was a tendency for third year students to overfill due to over-instrumentation of anterior teeth.The change in the curriculum has been justified, though room for improvement exists. The superior result found in the 5th year student cohort was most likely due to their relative experience, and the use of rotary instrumentation and dental operating microscopes. Endodontic teaching should further emphasize the importance of length control during endodontic treatment and more stringent steps may be necessary during patient allocation and clinical supervision of fourth year dental students.
Uropathogens and their antibiotic susceptibility profile in a tertiary carehospital
Authors: Agarwal Anjali , Srivastava Jyoti , Bose Seema , Maheshwari Ujjwal 
Published: July 2021

Urinary tract infections (UTI) are one of the most common infections in the community and hospitals. Uropathogens colonize the urinary tract and may ascend to bladder causing cystitis, if left untreated reach kidneys through ureters can be responsible for acute pyelonephritis and cause renal damage. The aim of the present study is to determine the prevalence of urinary tract infections and antibiotic susceptibility pattern in a tertiary care hospital.This is an observational study conducted in Microbiology department, Hind Institute of Medical Sciences, Barabanki.A total of 623 urine(mid-stream) samples were collected from indoor and outdoor departments of hospital and culture was done on UTI chromogenic agar using semiquantitative method. Antibiotic sensitivity test was performed using Kirby Bauer disc diffusion method.Prevalence of urinary tract infections is 29% in the study. (43%) is the most common micro-organism isolated followed by (13%), (11%), (10.4%), (8.8%), (3.3%), (1.6%), CONS & (1.1%) and (6.6%). The females(56.6%) are more commonly affected than males.In the present study, beta-lactamase inhibitors and aminoglycosides were effective drugs against gram negative bacteria. Vancomycin and linezolid were sensitive in gram positive bacteria. Nitrofurantoin is the promising drug in cases of uncomplicated UTI, and safe to use in pregnancy. High recurrence rates and antimicrobial resistance are responsible for increasing the burden of disease. It is advised to use the antibiotics judiciously as per the hospital antibiotic policy which will help prevent multidrug resistance micro-organism further reducing morbidity and mortality.
Prevalence of dermatophytes in patients attending a teaching hospital in Hyderabad, South India
Authors: Vara Aarthi , Khan Rozina Arshi , Narayan L Sadanand 
Published: July 2021

Dermatophytoses are a group of superficial fungal infections of keratinized tissues. Though they do not cause mortality they cause morbidity and pose a major public health problem especially in tropical countries like India. The present study is done to know the prevalence of dermatophytes and to identify the causative agents in Hyderabad area. A total of 180 samples were collected for a period of 1 year from infected skin, hair, and nails. Samples were collected under aseptic conditions and were then subjected to direct microscopy by KOH mount and culture on SDA. Dermatophytes were seen more in males (126/180). Direct microscopy by KOH mount revealed presence of fungal elements in (144/180) of samples. T.mentagrophytes was the most predominant isolate followed by T.rubrum and T.violaceum. Dermatophytic infections are worldwide in distribution with superficial mycoses being more prevalent in India where heat and moisture play an important role. Dermatophytosis has been reported throughout the year in the present study locality and an increase in prevalence of certain species was found.
Samodzielność wydatkowania środków publicznych a samorządowy program polityki zdrowotnej
Authors: Moś Szymon 
Published: July 2021

W obrębie samodzielności finansowej jednostki samorządu terytorialnego (j.s.t.) ponosząc wydatki na zadania własne, korzystają z konstytucyjnej samodzielności wydatkowania. Nie jest ona nieograniczona i podlega nadzorowi regionalnych izb obrachunkowych. Nadzór ten sprawowany jest na podstawie kryterium legalności, a jakakolwiek ingerencja władcza w decyzję j.s.t. nastąpić może dopiero ex post. W szczególności nie jest dopuszczalna ingerencja w decyzje finansowe samorządu w sferze wydatkowania na etapie podejmowania tych decyzji.
Wykonując zadania własne z zakresu ochrony zdrowia, j.s.t. opracowują, wdrażają i realizują samorządowe programy polityki zdrowotnej (s.p.p.z.). W procedurze opracowywania projektu s.p.p.z. podlega on opiniowaniu przez Prezesa Agencji Oceny Technologii Medycznych i Taryfikacji (nadzorowanego przez ministra właściwego do spraw zdrowia). Jednym ze stosowanych podczas tego opiniowania kryteriów jest kryterium skutków finansowych dla jednostek samorządu terytorialnego. Negatywna opinia uniemożliwia realizację samorządowego programu polityki zdrowotnej. Ponieważ opinia taka dokonywana jest ex ante, jej oparcie na kryterium skutków finansowych dla j.s.t. powoduje systemową niespójność z samodzielnością wydatkowania j.s.t., nadzorowaną jedynie ex post przez regionalną izbę obrachunkową.
Dostrzegając ogólną zasadność uczestnictwa Prezesa AOTMiT w procedurze oceny samorządowych programów polityki zdrowotnej, w artykule sfomułowano wnioski de lege ferenda zmierzające do zniwelowania obserwowanej niekoherencji.
Postępowanie w sprawie przeniesienia proboszcza w świetle KPK z 1983 r.
Authors: Leszczyński Grzegorz 
Published: July 2021

Zgodnie z kan. 1748 KPK motywem przeniesienia proboszcza może być albo dobro dusz, albo potrzeba lub pożytek Kościoła. Oznacza to, że w przeciwieństwie do motywów, jakie mogą skłonić biskupa diecezji do usunięcia proboszcza, skoncentrowanych wokół szkodliwości jego działania w parafii, którą kierował, w tym przypadku uwaga prawodawcy skupia się wokół motywów dotyczących nowej parafii lub innego urzędu, który biskup może mu powierzyć. Niniejszy artykuł wskazuje nie tylko na przyczyny przeniesienia proboszcza, ale w skrócie podaje również podstawowe etapy procedury.
Quasi-Regulatory Role of the Legal Opinions of the Supreme Court on the Example of the Case of Compensation for Non-Pecuniary Damage in the Family Dispute
Authors: Shumylo Mykhailo 
Published: July 2021

Judgments of the Supreme Court, their legal nature, tasks and importance have repeatedly been the subject of discussions among the legal scholars and the legal practitioners, so this issue will not be the main point of the article.Quasi-regulation as one of the most significant functions of the legal opinions of the Supreme Court will be described in the article on the example of family dispute cases.The legal opinions of the Supreme Court are generally acknowledged as quasi-precedents and the article contains the conclusion that such terminological definition is the most balanced as the Supreme Court caselaw could not be called precedent in the meaning of this definition in Anglo-Saxon law.The research has proved that quasi-precedents can set the quasi-legal regulation.In that context, however, it is important to distinguish that precedents can create legal regulation, while the quasi-precedents can provide the rule of law with additional regulatory content by its wider interpretation.This can be clearly observed when the Court of Cassation interprets in common the general and special legal provisions.It is proved that quasi-regulation, which is provided by the Supreme Court in certain cases, is the result of the several objective processes, including:–  convergence of Anglo-Saxon and Romano-Germanic Law;–  transformation of the national legal system from authoritarian soviet to democratic;–  gradual abandonment from positivistic interpretation of legal provision in favor of rule of law and faire justice (human-centered);–  more frequent application of dynamic interpretation of legal provisions.At the same time, it should be emphasized that quasi-regulation is not the prior task of the Supreme Court for the reason that ensuring the uniformity and sustainability of case law remains its basic function. Quasi-regulation is an additional instrument aimed at strengthening the rule of law in Ukraine.In this regard such an instrument is more useful when: (1) rules of positive law do not fulfill this function; (2) there is a need to use the legal regulation for resolving the conflicts of law and filling the gaps in legislation.Quasi-regulation contributes to the development of the doctrine of law and becomes an indicator for the legislator that certain relations need urgent regulation, that public relations have changed, become more complicated and need immediate legislative regulation, and that legislators demonstrate slow response tothe mentioned changes.