bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I would sooner die than give up”: Huxley and Darwin's deep disagreement
Authors: Winsor Mary P. 
Published: April 2021

AbstractThomas Henry Huxley and Charles Darwin discovered in 1857 that they had a fundamental disagreement about biological classification. Darwin believed that the natural system should express genealogy while Huxley insisted that classification must stand on its own basis, independent of evolution. Darwin used human races as a model for his view. This private and long-forgotten dispute exposes important divisions within Victorian biology. Huxley, trained in physiology and anatomy, was a professional biologist while Darwin was a gentleman naturalist. Huxley agreed with John Stuart Mill's rejection of William Whewell's sympathy for Linnaeus. The naturalists William Sharp Macleay, Hugh Strickland, and George Waterhouse worked to distinguish two kinds of relationship, affinity and analogy. Darwin believed that his theory could explain the difference. Richard Owen introduced the distinction between homology and analogy to anatomists, but the word homology did not enter Darwin's vocabulary until 1848, when he used the morphological concept of archetype in his work on Cirripedia. Huxley dropped the word archetype when Richard Owen linked it to Plato's ideal forms, replacing it with common plan. When Darwin wrote in theOrigin of Speciesthat the word plan gives no explanation, he may have had Huxley in mind. Darwin's preposterous story in theOriginabout a bear giving birth to a kangaroo, which he dropped in the second edition, was in fact aimed at Huxley.
Solving knapsack problems using a binary gaining sharing knowledge-based optimization algorithm
Authors: Agrawal Prachi , Ganesh Talari , Mohamed Ali Wagdy 
Published: April 2021

AbstractThis article proposes a novel binary version of recently developed Gaining Sharing knowledge-based optimization algorithm (GSK) to solve binary optimization problems. GSK algorithm is based on the concept of how humans acquire and share knowledge during their life span. A binary version of GSK named novel binary Gaining Sharing knowledge-based optimization algorithm (NBGSK) depends on mainly two binary stages: binary junior gaining sharing stage and binary senior gaining sharing stage with knowledge factor 1. These two stages enable NBGSK for exploring and exploitation of the search space efficiently and effectively to solve problems in binary space. Moreover, to enhance the performance of NBGSK and prevent the solutions from trapping into local optima, NBGSK with population size reduction (PR-NBGSK) is introduced. It decreases the population size gradually with a linear function. The proposed NBGSK and PR-NBGSK applied to set of knapsack instances with small and large dimensions, which shows that NBGSK and PR-NBGSK are more efficient and effective in terms of convergence, robustness, and accuracy.
Wire-in-Wire TiO2/C Nanofibers Free-Standing Anodes for Li-Ion and K-Ion Batteries with Long Cycling Stability and High Capacity
Authors: Su Die , Pei Yi , Liu Li , Liu Zhixiao , Liu Junfang , Yang Min , Wen Jiaxing , Dai Jing , Deng Huiqiu , Cao Guozhong 
Published: April 2021

AbstractWearable and portable mobile phones play a critical role in the market, and one of the key technologies is the flexible electrode with high specific capacity and excellent mechanical flexibility. Herein, a wire-in-wire TiO2/C nanofibers (TiO2 ww/CN) film is synthesized via electrospinning with selenium as a structural inducer. The interconnected carbon network and unique wire-in-wire nanostructure cannot only improve electronic conductivity and induce effective charge transports, but also bring a superior mechanic flexibility. Ultimately, TiO2 ww/CN film shows outstanding electrochemical performance as free-standing electrodes in Li/K ion batteries. It shows a discharge capacity as high as 303 mAh g−1 at 5 A g−1 after 6000 cycles in Li half-cells, and the unique structure is well-reserved after long-term cycling. Moreover, even TiO2 has a large diffusion barrier of K+, TiO2 ww/CN film demonstrates excellent performance (259 mAh g−1 at 0.05 A g−1 after 1000 cycles) in K half-cells owing to extraordinary pseudocapacitive contribution. The Li/K full cells consisted of TiO2 ww/CN film anode and LiFePO4/Perylene-3,4,9,10-tetracarboxylic dianhydride cathode possess outstanding cycling stability and demonstrate practical application from lighting at least 19 LEDs. It is, therefore, expected that this material will find broad applications in portable and wearable Li/K-ion batteries.
The delirium screening tool 4AT in routine clinical practice: prediction of mortality, sensitivity and specificity
Authors: Evensen Sigurd , Hylen Ranhoff Anette , Lydersen Stian , Saltvedt Ingvild 
Published: April 2021

Abstract
Purpose
Delirium is common and associated with poor outcomes, partly due to underdetection. We investigated if the delirium screening tool 4 A’s test (4AT) score predicts 1 year mortality and explored the sensitivity and specificity of the 4AT when applied as part of a clinical routine.

Methods
Secondary analyses of a prospective study of 228 patients acutely admitted to a Medical Geriatric Ward. Physicians without formal training conducted the index test (the 4AT); a predefined cut-off ≥ 4 suggested delirium. Reference standard was delirium diagnosed by two geriatricians using the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5). We calculated hazard ratios (HR) using Cox regression based on the groups 4AT = 0, 1–3, 4–7 and ≥ 8, first unadjusted, then adjusted for the covariates age, comorbidity, and personal activities of daily living. We calculated sensitivity, specificity, and the area under the receiver operating curve (AUC).

Results
Mean age of patients was 86.6 years, 139 (61.0%) were female, 78 (34.2%) had DSM-5 delirium; of these, 56 had 4AT-delirium. 1 year mortality was 27.6% (63 patients). Compared to 4AT score 0, the group 4AT ≥ 8 had increased 1 year mortality (HR 2.86, 95% confidence interval 1.28–6.37, p = 0.010). The effect was reduced in multiadjusted analyses (HR 1.69, 95% confidence interval 0.70–4.07, p = 0.24). Sensitivity, specificity, and AUC were 0.72, 0.84, and 0.88, respectively.

Conclusions
4AT ≥ 8 indicates increased mortality, but the effect was reduced in multiadjusted analyses. 4AT had acceptable sensitivity and specificity when applied as a clinical routine.
One Size Does Not Fit All: Individuality and Perceptions of Improvement and Satisfaction Among TE Students
Authors: Koenig Eric , Guertler Katherine 
Published: April 2021

AbstractAcademic self-regulation is a key factor for motivation and learning achievement. Yet with the large range of individual factors, this is not a one-size-fits-all proposition. This study of L2 Technical English students at two German universities explored learners’ expectations and motivations, in particular regarding self-regulation and self-efficacy via the individual’s time investment in self-led study. In an initial survey, learners (N=1646) reported on their English skill levels and anticipated learning habits. Complementarily, the retrospective survey investigated learners’ (N=796) actual behavior during the course, their perceptions of language skill improvement, and their satisfaction. The initial survey indicates a clear understanding that time investment in self-regulated study will lead to greater improvement, an outcome confirmed in the retrospective survey. Additionally, students who invested more time in their coursework were more satisfied with their achievement, although most learners acknowledge they should have studied more. The results verify that learners recognize the nexus between self-regulation and language skill improvement, yet university students are not satisfied with their capacity to self-regulate their language learning strategies. While differences in students’ skill levels and academic self-efficacy result in divergent degrees of progress, students of all types report benefits to their language skills when motivated to self-regulated study.
Evaluation of multi-asset investment strategies with digital assets
Authors: Petukhina Alla , Sprünken Erin 
Published: April 2021

AbstractThe drastic growth of the cryptocurrencies market capitalization boosts investigation of their diversification benefits in portfolio construction. In this paper with a set of classical and modern measurement tools, we assess the out-of-sample performance of eight portfolio allocation strategies relative to the naive 1/N rule applied to traditional and crypto-assets investment universe. Evaluated strategies include a range from classical Markowitz rule to the recently introduced LIBRO approach (Trimborn et al. in Journal of Financial Econometrics 1–27, 2019). Furthermore, we also compare three extensions for strategies with respect to input estimators applied. The results show that in the presence of alternative assets, such as cryptocurrencies, mean–variance strategies underperform the benchmark portfolio. In contrast, CVaR optimization tends to outperform the benchmark as well as geometric optimization, although we find a strong dependence of the former’s success on trading costs. Furthermore, we find evidence that liquidity-bounded strategies tend to perform very well. Thus, our findings underscore the non-normal distribution of returns and the necessity to control for liquidity constraints at alternative asset markets.
High‐Resolution 3‐D Shear Wave Velocity Model of Northern Taiwan via Bayesian Joint Inversion of Rayleigh Wave Ellipticity and Phase Velocity With Formosa Array
Authors: Liu Cheng‐Nan , Lin Fan‐Chi , Huang Hsin‐Hua , Wang Yu , Berg Elizabeth M. , Lin Cheng‐Horng 
Published: April 2021

AbstractThe Formosa array, with 137 broadband seismometers and ∼5 km station spacing, was deployed recently in Northern Taiwan. Here by using eight months of continuous ambient noise records, we construct the first high‐resolution three‐dimensional (3‐D) shear wave velocity model of the crust in the area. We first calculate multi‐component cross‐correlations to extract robust Rayleigh wave signals. We then determine phase velocity maps between 3 and 10 s periods using Eikonal tomography and measure Rayleigh wave ellipticity at each station location between 2 and 13 s periods. For each location, we jointly invert the two types of Rayleigh wave measurements with a Bayesian‐based inversion method for a one‐dimensional shear wave velocity model. All piecewise continuous one‐dimensional models are then used to construct the final 3‐D model. Our 3‐D model reveals upper crustal structures that correlate well with surface geological features. Near the surface, the model delineates the low‐velocity Taipei and Ilan Basins from the adjacent fast‐velocity mountainous areas, with basin geometries consistent with the results of previous geophysical exploration and geological studies. At a greater depth, low velocity anomalies are observed associated with the Linkou Tableland, Tatun Volcano Group, and a possible dyke intrusion beneath the Southern Ilan Basin. The model also provides new geometrical constraints on the major active fault systems in the area, which are important to understand the basin formation, orogeny dynamics, and regional seismic hazard. The new 3‐D shear wave velocity model allows a comprehensive investigation of shallow geologic structures in the Northern Taiwan.
Spatial Distribution of Dissolved Methane Over Extreme Oceanographic Gradients in the Subtropical Eastern South Pacific (17° to 37°S)
Authors: Farías L. , Troncoso M. , Sanzana K. , Verdugo J. , Masotti I. 
Published: April 2021

AbstractMethane (CH4) is one of the most powerful greenhouse gases with the capacity to influence the Earth's radiative budget as well as contribute to atmospheric chemistry. Natural oceanic production makes up to ∼4% of the overall global CH4 emissions, however, there is uncertainty around the accuracy of this value due to a lack of accurate measurements. Such is the case in the Subtropical Eastern South Pacific Ocean (SESP), a region with pronounced chlorophyll‐a and oxygen gradients, which in turn affect the microbial CH4 cycling. This study was conducted during spring‐summer (2014–2016) in the SESP. The region (∼17°–37°S/71°–110°W) is separated into (i) eutrophic, (ii) mesotrophic, and (iii) oligotrophic areas, according to oceanographic and biogeochemical criteria. The SESP presents high CH4 zonal variability with levels ranging from 0.63 to 33.4 nmol L−1, corresponding to 29% and 1,423% saturation, respectively. High CH4 concentrations (>1,000% saturation) are observed in the narrow eutrophic area subjected to coastal upwelling. These conditions clearly differ to those observed in the extended oligotrophic subtropical gyre (∼100% saturation). Furthermore, CH4 also tends to accumulate in the mesotrophic area (with upto 1,423% saturation), where oceanographic conditions as stratification, mesoscale eddies and island mass effect could trigger the presence of a microbial biomass that may be able to induce CH4 regeneration. The CH4 efflux is estimated to be between 0.13 and 19.1 µmol m−2 d−1 (mean ± SD = 4.72 ± 4.67) and the SESP has an emission rate of ∼87.9 Gg CH4 yr−1.
APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease
Authors: Brookhouser Nicholas , Raman Sreedevi , Frisch Carlye , Srinivasan Gayathri , Brafman David A. 
Published: April 2021

AbstractGenome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk of AD. On the other hand, longitudinal studies have shown that the presence of the APOE2 variant reduces the lifetime risk of developing AD by 40 percent. While there has been significant research that has identified the risk-inducing effects of APOE4, the underlying mechanisms by which APOE2 influences AD onset and progression have not been extensively explored. In this study, we utilize an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta (Aβ) peptides in hiPSC-derived neural cultures. Mechanistically, analysis of pure populations of neurons and astrocytes derived from these neural cultures revealed that mitigating effects of APOE2 are mediated by cell autonomous and non-autonomous effects. In particular, we demonstrated the reduction in Aβ is potentially driven by a mechanism related to non-amyloidogenic processing of amyloid precursor protein (APP), suggesting a gain of the protective function of the APOE2 variant. Together, this study provides insights into the risk-modifying effects associated with the APOE2 allele and establishes a platform to probe the mechanisms by which APOE2 enhances neuroprotection against AD.
Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice
Authors: Aljohani Hanan , Stains Joseph P. , Majumdar Sunipa , Srinivasan Deepa , Senbanjo Linda , Chellaiah Meenakshi A. 
Published: April 2021

AbstractL-plastin (LPL) was identified as a potential regulator of the actin-bundling process involved in forming nascent sealing zones (NSZs), which are precursor zones for mature sealing zones. TAT-fused cell-penetrating small molecular weight LPL peptide (TAT- MARGSVSDEE, denoted as an inhibitory LPL peptide) attenuated the formation of NSZs and impaired bone resorption in vitro in osteoclasts. Also, the genetic deletion of LPL in mice demonstrated decreased eroded perimeters and increased trabecular bone density. In the present study, we hypothesized that targeting LPL with the inhibitory LPL peptide in vivo could reduce osteoclast function and increase bone density in a mice model of low bone mass. We injected aging C57BL/6 female mice (36 weeks old) subcutaneously with the inhibitory and scrambled peptides of LPL for 14 weeks. Micro-CT and histomorphometry analyses demonstrated an increase in trabecular bone density of femoral and tibial bones with no change in cortical thickness in mice injected with the inhibitory LPL peptide. A reduction in the serum levels of CTX-1 peptide suggests that the increase in bone density is associated with a decrease in osteoclast function. No changes in bone formation rate and mineral apposition rate, and the serum levels of P1NP indicate that the inhibitory LPL peptide does not affect osteoblast function. Our study shows that the inhibitory LPL peptide can block osteoclast function without impairing the function of osteoblasts. LPL peptide could be developed as a prospective therapeutic agent to treat osteoporosis.
Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population
Authors: Gervais Olivier , Ueno Kazuko , Kawai Yosuke , Hitomi Yuki , Aiba Yoshihiro , Ueta Mayumi , Nakamura Minoru , Tokunaga Katsushi , Nagasaki Masao 
Published: April 2021

AbstractWhile the advent of GWAS more than a decade ago has ushered in remarkable advances in our understanding of complex traits, the limitations of single-SNP analysis have also led to the development of several other approaches. Simulation studies have shown that the regional heritability mapping (RHM) method, which makes use of multiple adjacent SNPs jointly to estimate the genetic effect of a given region of the genome, generally has higher detection power than single-SNP GWAS. However, thus far its use has been mostly limited to agricultural settings, and its potential for the discovery of new genes in human diseases is yet to be fully exploited. In this study, by applying the RHM method to primary biliary cholangitis (PBC) in the Japanese population, we identified three novel loci (STAT4, ULK4, and KCNH5) at the genome-wide significance level, two of which (ULK4 and KCNH5) have not been found associated with PBC in any population previously. Notably, these genes could not be detected by using conventional single-SNP GWAS, highlighting the potential of the RHM method for the detection of new susceptibility loci in human diseases. These findings thereby provide strong empirical evidence that RHM is an effective and practical complementary approach to GWAS in this context. Also, liver tissue mRNA microarray analysis revealed higher gene expression levels in ULK4 in PBC patients (P < 0.01). Lastly, we estimated the common SNP heritability of PBC in the Japanese population (0.210 ± 0.026).
Nanometer-size Na cluster formation in micropore of hard carbon as origin of higher-capacity Na-ion battery
Authors: Youn Yong , Gao Bo , Kamiyama Azusa , Kubota Kei , Komaba Shinichi , Tateyama Yoshitaka 
Published: April 2021

AbstractDevelopment of high-energy-density anode is crucial for practical application of Na-ion battery as a post Li-ion battery. Hard carbon (HC), though a promising anode candidate, still has bottlenecks of insufficient capacity and unclear microscopic picture. Usage of the micropore has been recently discussed, however, the underlying sodiation mechanism is still controversial. Herein we examined the origin for the high-capacity sodiation of HC, based on density functional theory calculations. We demonstrated that nanometer-size Na cluster with 3–6 layers is energetically stable between two sheets of graphene, a model micropore, in addition to the adsorption and intercalation mechanisms. The finding well explains the extended capacity over typical 300 mAhg−1, up to 478 mAhg−1 recently found in the MgO-templated HC. We also clarified that the MgO-template can produce suitable nanometer-size micropores with slightly defective graphitic domains in HC. The present study considerably promotes the atomistic theory of sodiation mechanism and complicated HC science.
Targets identified from exercised heart: killing multiple birds with one stone
Authors: Wang Hongyun , Xie Yuling , Guan Longfei , Elkin Kenneth , Xiao Junjie 
Published: April 2021

AbstractCardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and excess alcohol use. Exercise targets several molecules and protects hearts against many of these physiological and pathological stimuli. Accordingly, it is widely recognized as an effective therapeutic strategy for CVD. To investigate the molecular mechanism of exercise in cardiac protection, we identify and describe several crucial targets identified from exercised hearts. These targets include insulin-like growth factor 1 (IGF1)-phosphatidylinositol 3 phosphate kinase (PI3K)/protein kinase B (AKT), transcription factor CCAAT/enhancer-binding protein β (C/EBPβ), cardiac microRNAs (miRNAs, miR-222 and miR-17-3p etc.), exosomal-miRNAs (miR-342, miR-29, etc.), Sirtuin 1 (SIRT1), and nuclear factor erythroid 2‑related factor/metallothioneins (Nrf2/Mts). Targets identified from exercised hearts can alleviate injury via multiple avenues, including: (1) promoting cardiomyocyte proliferation; (2) facilitating cardiomyocyte growth and physiologic hypertrophy; (3) elevating the anti-apoptotic capacity of cardiomyocytes; (4) improving vascular endothelial function; (5) inhibiting pathological remodeling and fibrosis; (6) promoting extracellular vesicles (EVs) production and exosomal-molecules transfer. Exercise is one treatment (‘stone’), which is cardioprotective via multiple avenues (‘birds’), and is considered ‘killing multiple birds with one stone’ in this review. Further, we discuss the potential application of EV cargos in CVD treatment. We provide an outline of targets identified from the exercised heart and their mechanisms, as well as novel ideas for CVD treatment, which may provide novel direction for preclinical trials in cardiac rehabilitation.
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
Authors: Saunders Kevin O. , Pardi Norbert , Parks Robert , Santra Sampa , Mu Zekun , Sutherland Laura , Scearce Richard , Barr Maggie , Eaton Amanda , Hernandez Giovanna , Goodman Derrick , Hogan Michael J. , Tombacz Istvan , Gordon David N. , Rountree R. Wes , Wang Yunfei , Lewis Mark G. , Pierson Theodore C. , Barbosa Chris , Tam Ying , Matyas Gary R. , Rao Mangala , Beck Zoltan , Shen Xiaoying , Ferrari Guido , Tomaras Georgia D. , Montefiori David C. , Weissman Drew , Haynes Barton F. 
Published: April 2021

AbstractThe development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Here, we show that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies. Immunization with mRNA-LNP encoding Zika premembrane and envelope or HIV-1 Env gp160 induces durable neutralizing antibodies for at least 41 weeks. Doses of mRNA-LNP as low as 5 μg are immunogenic in macaques. Thus, mRNA-LNP can be used to rapidly generate single or multi-component vaccines, such as sequential vaccines needed to protect against HIV-1 infection. Such vaccines would be as or more immunogenic than adjuvanted recombinant protein vaccines in primates.
Dynamic control of spin-wave propagation
Authors: Toedt Jan-Niklas , Hansen Wolfgang 
Published: April 2021

AbstractIn this work we present a method to dynamically control the propagation of spin-wave packets. By altering an external magnetic field the refraction of the spin wave at a temporal inhomogeneity is enabled. Since the inhomogeneity is spatially invariant, the spin-wave impulse remains conserved while the frequency is shifted. We demonstrate the stopping and rebound of a traveling Backward-Volume type spin-wave packet.