bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Respectful Maternity Care Interventions for Women Using Maternal Health Care: A Systematic Review Protocol
Authors: Kasaye Habtamu , Baird Kathleen , Sheehy Annabel , Scarf Vanessa , Cummins Allison 
Published: December 2021

Abstract
Background: Studies have indicated the mistreatment of women during maternal health care provision as being a driving factor for women eschewing professional care. The mistreatment of women is not only a violation of human rights, but also a significant contributor to poor-quality maternal care. Various strategies aimed at preventing the mistreatment of women and enhancing respectful maternity have been proposed, however, the positive effects and outcomes of these interventions necessitate further clarity. This systematic review will examine the effectiveness of respectful maternity care intervention programs in preventing the mistreatment of women whilst enhancing respectful maternity care in health facilities.Methods: A systematic review will be undertaken according to the Preferred Reporting Items for Systematic and Meta-Analysis (PRISMA)2020. Both published and unpublished randomised, non-randomised controlled and observational studies obtained from PubMed, CINHAL, EMBASE, AJOL, and other databases and grey literature sources will be assessed against an inclusion and exclusion criteria to include in the review. Two independent reviewers will assess the papers selected for retrieval to ensure methodological validity. Standardised critical appraisal instruments from the Critical Appraisal Skills Program (CASP) and Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) will be used. The data will be extracted from papers included in the review using two independent reviewers' standardised data extraction tool. Evidence synthesis and, wherever possible, meta-analysis will be performed. Certainty of the evidence will be assessed by using GRADE criteria. Systematic review protocol registration: Submitted to PROSPERO on 9th of November 2021 (ID. 287049).
Colonic Mucosa Barrier Defects in Collagenous and Ischemic Colitis
Authors: Sakellariou Stratigoula , Perdiki Μarina , Palamaris Kostas , Bamias Giorgos , Delladetsima Ioanna 
Published: December 2021

Abstract
Aims The subepithelial myofibroblasts (SEMFs) and the subepithelial band of macrophages (SEBM) are major components of the colonic mucosa barrier. Although their role in homeostasis is widely recognized, their contribution to disease states is largely unknown. The aim of the study was to explore histological characteristics of SEMFs and SEBM in collagenous and ischemic colitis.Methods Ten colonic biopsies of collagenous colitis, 10 of ischemic colitis and 10 control biopsies of normal mucosa were examined. SEMFs, SEBM and lamina propria macrophages were identified immunohistochemically by aSMA and CD68 respectively.ResultsIn collagenous colitis, SEMFs were rarely detectable in the collagenous band while in the lower lamina propria cell processes were formed. SEBM was preserved in areas with a collagenous layer up to 20μm. In thicker layers, it was fragmented and gradually disappeared in parallel with engulfment of enlarged macrophages. In the lower lamina propria macrophages were usually increased.In ischemic colitis, rounding, disintegration and extinction of SEMFs constituted successive alterations coinciding with crypt shrinkage and denudation. SEBM displayed total or almost total abolishment in areas with crypt damage and stroma fibrosis but also in sights with minimal changes.ConclusionIn collagenous colitis, alterations of mucosa barrier are related to collagenous layer thickness. SEMFs changes probably reflect derangement of differentiation and migration while SEMB alterations seem to be compensated by macrophage activation and numerical increase in lamina propria. The striking damage of mucosa barrier in ischemic colitis is indicative of its high sensitivity to hypoxia and hypoperfusion. The histological differences between collagenous colitis and ischemic colitis may be proven of differential diagnostic significance.
Correlations for Melting Time and Melt Fraction for Bottom Charged Tube in Tube Phase Change Material Heat Exchanger
Authors: Raj Lanka Sandeep , Sreenivas Sane , Prasad Bandaru Durga 
Published: December 2021

Abstract
Multiple factors govern the Thermo-hydraulic behaviour of Latent heat storage devices. The correlation among these factors varies from case to case. In this work, a concentric tube in tube latent heat storage system is numerically modelled for the bottom charging case. Fixed grid enthalpy porosity approach is adopted to account for phase change. The numerical model’s independence is achieved by testing mesh size, time step, and maximum iterations per time step. The computational approach is validated against the experimental data. Non-dimensional parameters viz Rayleigh Number (3.04x105 to 65.75 x105), Stefan Number (0.2 to 1), Reynolds Number (600 to 3000), and L/D ratio (2 to 15) are varied in the respective ranges mentioned in parenthesis. Stefan number is found to have a major influence on the Melt Fraction and Melting time, compared to Rayleigh Number and Reynolds Number. Correlations are presented for quantifying the melt fraction and dimensionless melting time.
Health Literacy And Health-Related Quality of Life Among Patients With Cardiovascular Disease in Tagus Valley Regional Health Hospital, Portugal: A Cross-Sectional Study
Authors: Winarni Wiwin , Amendoeira Jose , Esparteiro Maria Joao 
Published: December 2021

Abstract
Purpose The aims of this study were to examine the association between health literacy (HL) and health-related quality of life (HRQoL) and to investigate the possible determinants of both variables among patients with cardiovascular diseases in Tagus Valley Regional Health Hospital, Portugal.Methods A descriptive cross-sectional study was conducted among 28 patients with CVD. A convenient sampling technique was used to enrol the study participants. Data were collected using a validated Portuguese version of Short Assessment of Health Literacy (SAHPLA-23) and a validated Portuguese version of Short Form Health Survey (SF-36v2). The multiple linear regression was used to investigate the possible associated variables and the association between HL and HRQoL by using SPSS version 25.Results The results showed the majority of patients with CVD had inadequate HL (89.3%). The majority of the participants had poor HRQoL with Physical Component Score (PCS) scored lower (38.77±9.9) than the Mental Component Score (MCS) (44.13±9.9). Educational level was found to be associated with HL. Level of education, employment status, family history of CVD and history of readmission because of CVD were the variables found to be associated with the PCS. However, no variable was found to be associated with the MCS of QoL. HL was shown to be the best predictor of the PCS (β=0.518, p=0.002) while the history of readmission because of CVD was identified as the second-best predictor of the PCS (β=-0.373, p=0.022). Conclusions Health literacy was significantly associated with the PCS of HRQoL.
Correlation Research Between Gondola Car Body Structure And Weld Stress Based On Asymmetry Coefficient
Authors: Liu Wenfei , Zhang Li , He Liwen , Gao Zhixiong , Pu Xiongtao 
Published: December 2021

Abstract
In order to find out the root cause of cross bearer welds’ cracks on the general purpose gondola cars, the relationship between asymmetric structure and stress distribution is studied in this paper. Firstly, the concept of asymmetry coefficient is proposed, and the asymmetric coefficients’ calculation methods of independent and dependent variables are given respectively in two-dimensional space. Secondly, according to the different positions of side column 1 and side column 2, 30 local models are established, the cross bearer weld stresses are extracted after finite element simulation, and the stress distribution clusters are formed. Finally, the asymmetry coefficients of the side columns are calculated, and the correlation between the positions of the side columns and the weld stresses is studied by the methods of Pearson correlation coefficient and complex correlation coefficient. The results show that the correlation between the stress of cross bearer weld 2 and the positions of the side columns is much higher. This research can not only provide an important basis for the structural optimization of 80t gondola car body, and it also provides reference for the structural design of the gondola car body.
Lagged effects of rainfall on malaria: a case study of Meghalaya
Authors: Chungkham Holendro Singh , Marbaniang Strong P , Gogoi Hritiz 
Published: December 2021

Abstract
Background: Meghalaya contributes about twenty per cent of India's total malaria death and is one of the high malaria endemic states in India, very susceptible to malaria transmission mainly due to favorable climatic conditions that mostly facilitate the transmission. In the relationship between malaria and meteorological factors, existing studies mainly focus on the interaction between different climatic factors, while interaction within one specific climatic predictor at different ag times has been largely neglected. This paper aims to explore the interaction of lagged rainfalls and their impact on malaria incidence.
Methods: The district monthly malaria records from Jan 2005 to December 2017 was collected from the Department of Health Services (Malaria), Government of Meghalaya. The district monthly meteorological records from Jan 2005 to December 2017 was collected from the Directorate of Agriculture, Government of Meghalaya, in which average temperature (℃), humidity (%) and rainfall (mm) had been recorded. Monthly malaria cases and three climatic variables of 4 districts in Meghalaya from 2015 to 2017 were analysed with the varying coefficient-distributed lag non-linear model. The missing climatic values were imputed using Kalman Smoothing on structural time series using the package imputeTS in R.
Results: During the period 2005-2017, a total of 309133 malaria cases were reported in all the districts under study. The monthly average rainfall ranges from a minimum of 181.79 mm in South Garo to a maximum of 367.87 in Jaintia. Also, South Garo and East Khasi are the hottest and the coolest place understudy with 26.96 and 16.86 degrees Celsius respectively. Rainfall levels in the first-month lag affect the non-linear patterns between the incidence of malaria and rainfall at each lag time. The low rainfall level at the first-month lag may promote malaria incidence as rainfall increases. However, for the high rainfall level at the first-month lag, malaria incidence decreases as rainfall increases.
Conclusion: The interaction effect between lagged rainfalls on malaria incidence was observed in this study, and highlights its importance for future studies to better understand and predict malaria transmission.
Group Penalized Logistic Regressions Predict Ovarian Cancer ∗
Authors: Hu Xuemei , Xie Ying , Yang Yanlin , Jiang Huifeng 
Published: December 2021

Abstract
Objectives: Ovarian cancer ranks fifirst among gynecological cancers in terms of the mortality rate. Accurately diagnosing ovarian benign tumors and malignant tumors is of immense important. The goal of this paper is to combine group LASSO/SCAD/MCP penalized logistic regression with machine learning procedure to further improve the prediction accuracy to ovarian benign tumors and malignant tumors prediction problem. Methods: We combine group LASSO/SCAD/MCP penalty with logistic regression, and propose group LASSO/SCAD/MCP penalized logistic regression to predict the benign and malignant ovarian cancer. Firstly, we select 349 ovarian cancer patients data and divide them into two sets: one is the training set for learning, and the other is the testing set for checking, and then choose 46 explanatory variables and divide them into 11 difffferent groups. Secondly, we apply the training set and group coordinate descent algorithm to obtain group LASSO/SCAD/MCP estimator, and apply the testing set to compute confusion matrix, accuracy, sensitivity and specifificity. Finally, we compare the prediction performance for group LASSO/SCAD/MCP penalized logistic regression with that for artifificial neural network (ANN) and support vector machine (SVM). Results: Group LASSO/SCAD/MCP/ penalized logistic regression selects 6/4/1 groups. The prediction accuracy and AUC for group MCP/SCAD/LASSO penalized logistic regression/SVM/ANN is 93.33%/85.71%/82.26%/74.29%/72.38% and 0.892/0.852/0.823/0.639/0.789, respectively. Conclusions: Group MCP/SCAD/LASSO penalized logistic regression performs than SVM and ANN in terms of prediction accuracy and AUC. In particular, group MCP penalized logistic regression predicts the best. Therefore, we suggest group MCP penalized logistic regression to predict ovarian tumors.
Comparison of the Human Gut Microbiota between Normal Control Subjects and Patients with Colonic Polyps and Colorectal Cancer
Authors: Uppakarn Kittipot , Bangpanwimon Khotchawan , Hongpattarakere Tipparat , Wanitsuwan Worrawit 
Published: December 2021

Abstract
Background: The human gut microbiota has been related to numerous colonic diseases. To identify colorectal cancer (CRC)-associated microbiota, the gut microbiomes of patients with colonic polyps and CRC compared to normal controls were analyzed.Methods: Between July and December 2020, forty-four stool samples were obtained from participants older than 50 years who were scheduled for elective colonoscopies at the Surgery Clinic, Songklanagarind Hospital. The samples were divided into 3 groups (17 normal control, 17 colonic polyps, and 10 CRC) and were collected for analysis with a 16s metagenomic sequencing library preparation with MiSeq Reporter software (MSR) following the protocol of the 16s metagenomics workflow. The microbiome data were analyzed with Kruskal–Wallis test with the Dunn-Bonferroni post hoc method.Results: The relative proportions of beneficial butyrate-producers Kineothrix alysoides, Eubacterium rectale, and Roseburia inulinsivorans were significantly higher in healthy control and colonic polyp groups compared with the CRC group at the top three lowest p-values. The recommended CRC biomarker Clostridium symbiosum was shown in a significantly higher proportion in the CRC group than in the normal control group. The prevalences and relative proportion of the novel CRC-associated species Acutalibacter muris and the familiar CRC-associated species Christensenella massiliensis and lntestinimonas butyriciproducens were significantly higher in the CRC group than in the normal control and colonic polyp groups at the top three lowest p-values.Conclusions: A correlation between specific bacteria and clinical outcomes was found in this pilot study. The microbiome data revealed possible microbial biomarkers associated with CRC. Studies with larger numbers of stool samples are required to substantiate our findings.
Divergent Actions of Pyruvate and ATP in Glucose-mediated Irinotecan Chemoresistance in Colorectal Cancer
Authors: Huang Chung-Yen , Pai Yu-Chen , Yu Linda Chia-Hui 
Published: December 2021

Abstract
Background: Altered glucose metabolism is associated with chemoresistance in colorectal cancer (CRC). The aim of this study was to illustrate the molecular mechanisms of glucose-mediated chemoresistance against irinotecan, a topoisomerase I inhibitor, focusing on the distinct roles of metabolites such as pyruvate and ATP in modulating cell death and proliferation. Methods: Four human CRC cell lines, tumorspheres, and mouse xenograft models were treated with various doses of irinotecan in the presence of high concentrations of glucose, pyruvate or ATP-encapsulated liposomes. Cell apoptosis was measured by DNA fragmentation and caspase activities, and necroptosis was evaluated by immunoprecipitation of receptor-interacting protein kinase (RIP) 1/3 complex. Cell cycles were assessed by flow cytometric analysis.Results: Human CRC cell lines treated with irinotecan in the presence of high glucose displayed increased cell viability and larger xenograft tumor sizes in mouse models compared to those treated in the presence of normal glucose. Irinotecan induced apoptosis and necroptosis, both of which were mitigated by high glucose. Liposomal ATP prevented irinotecan-induced apoptosis, while it had no effect on necroptosis. In contrast, pyruvate attenuated the RIP1/3-dependent necroptosis via free radical scavenging, without modulating apoptotic levels. Regarding the cell cycle, liposomal ATP aggravated irinotecan-induced G0/G1 shift whereas pyruvate diminished the G0/G1 shift, showing opposite effects on proliferation. Last, tumorsphere structural damage, an index of solid tumor responsiveness to chemotherapy, was determined. Liposomal ATP increased tumorsphere sizes while pyruvate prevented the deformation of spheroid mass. Conclusions: Glucose metabolites confer tumor chemoresistance via multiple modes of action. Glycolytic pyruvate attenuated irinotecan-induced necroptosis and potentiated drug insensitivity by shifting cells from a proliferative to quiescent state. On the other hand, ATP decreased irinotecan-induced apoptosis and promoted active cell proliferation, which might contribute to tumor recurrence.
Out of Hospital Cardiac Arrest (OHCA): Experience of a Bystander CPR Training Program in Karachi, Pakistan
Authors: Khan Uzma Rahim , Khudadad Umerdad , Baig Noor , Ahmed Fareed , Raheem Ahmed , Hisam Butool , Khan Nadeem Ullah , Hock Marcus Ong Eng , Razzak Junaid Abdul 
Published: December 2021

Abstract
Background: Nearly 90% of out-of-hospital cardiac arrest (OHCA) patients are witnessed, yet only 2.3% received bystander CPR (cardiopulmonary resuscitation in Pakistan. This study aimed to determine retention of knowledge and skills of Hands-Only CPR among community participants in early recognition of OHCA and initiation of CPR in Karachi, Pakistan.Methods: The pre and post-tests were conducted among participants from diverse non-health-related backgrounds from July 2018 to October 2019. Participants were tested for knowledge and skills of CPR before training (pre-test), immediately after training (post-test), and six months after training (retention test). All the participants received CPR training through video and scenario-based demonstration using manikins. Post-training CPR skills of the participants were assessed using a pre-defined performance checklist. The evaluator read out numerous case scenarios to the participants, such as drowning, poisoning, and road traffic injuries, etc., and then asked them to perform the critical steps of CPR identified in the scenario on manikins. The primary outcome was the mean difference in the knowledge score and skills of the participants related to the recognition of OHCA and initiation of CPR. Results: The pre and post-tests were completed by 722 participants, whereas the retention test after 6 months was completed by 358 participants. The mean knowledge score related to the recognition of OHCA, and initiation of CPR improved significantly (p <0.001) from pre-test (47.2/100, ±13.2) to post-test (69.9/100, ±12). The mean CPR knowledge after six months (retention) reduced slightly from (69.9/100, ±12) to (64.8/100, ±9.3). The CPR skill retention for various components (correct placement of the heel of hands, complete chest recoil, check for scene safety, check for a response, and activate emergency response system) slightly deteriorated from 79% in the post-test to 72% in re-test. However, participants performed slightly better on achieving an adequate rate of chest compressions from 73.7% in post-test to 75.5% in re-test.Conclusion: Community members with non-health backgrounds can learn and retain CPR skills, allowing them to be effective bystander CPR providers in OHCA situations. We recommend training the mass population in Pakistan regarding CPR to increase the survival rate from OHCA.
Uncertainty-aware Visual Analytics - Scope, Oppertunities and Challenges
Authors: Maack Robin Georg Claus , Scheuermann Gerik , Hagen Hans , Peñaloza Jose Tiberio Hernández , Gillmann Christina 
Published: December 2021

Abstract
In many applications, Visual Analytics(VA) has developed into a standard tool to ease data access and knowledge generation. Unfortunately, many data sources, used in the VA process, are affected by uncertainty. In addition, the VA cycle itself can introduce uncertainty to the knowledge generation process. The classic VA cycle does not provide a mechanism to handle these sources of uncertainty. In this manuscript, we aim to provide an extended VA cycle that is capable of handling uncertainty by quantification, propagation, and visualization. Different data types and application scenarios that can be handled by such a cycle, examples, and a list of open challenges in the area of uncertainty-aware VA are provided.
A Foliar Pigment-Based Bioassay for Interrogating Chloroplast Signalling Reveals that Chlorophyll Biosynthesis Requires Carotenoid Isomerisation.
Authors: Dhami Namraj , Pogson Barry J , Tissue David T , Cazzonelli Christopher I 
Published: December 2021

Abstract
Background: Plastid-derived metabolites can signal control over nuclear gene expression, chloroplast biogenesis, and chlorophyll biosynthesis. Norflurazon (NFZ) inhibition of carotenoid biosynthesis in seedlings can elicit a protoporphyrin retrograde signal that controls chlorophyll and chloroplast biogenesis. Recent evidence reveals that plastid development can be regulated by carotenoid cleavage products called apocarotenoids. The key steps in carotenoid biosynthesis and catabolism that generate apocarotenoid signalling metabolites in foliar tissues remains to be elucidated. Here, we established an Arabidopsis foliar pigment-based bioassay using detached rosettes to differentiate plastid signalling processes in young expanding leaves containing dividing cells with active chloroplast biogenesis, from fully expanded leaves containing mature chloroplasts. Results: We demonstrate that environmental (extended darkness and cold exposure) as well as chemical (norflurazon; NFZ) inhibition of carotenoid biosynthesis can reduce chlorophyll levels in young, but not older leaves following a 24 h of rosette treatment. Mutants that disrupted xanthophyll accumulation, phytohormone biosynthesis (abscisic acid and strigolactone), or enzymatic carotenoid cleavage, did not alter chlorophyll levels in young or old leaves. Perturbations in acyclic cis-carotene biosynthesis revealed that disruption of CAROTENOID ISOMERASE (CRTISO), but not ZETA-CAROTENE ISOMERASE (Z-ISO) activity, reduced chlorophyll levels in young but not older leaves of plants growing under a long photoperiod. NFZ-induced inhibition of PHYTOENE DESATURASE (PDS) activity triggered phytoene accumulation more so in younger relative to older leaves from both WT and the crtiso mutant, indicating a continued substrate supply from the methylerythritol 4-phosphate (MEP) pathway for carotenogenesis. NFZ treatment of WT and crtiso mutant rosettes reveal similar, additive, and opposite effects on individual pigment accumulation.Conclusion: The Arabidopsis foliar pigment-based bioassay was used to differentiate signalling events elicited by environmental, chemical, genetic, and combinations thereof, that control chlorophyll biosynthesis. Genetic perturbations that impaired xanthophyll biosynthesis and/or carotenoid catabolism did not affect chlorophyll biosynthesis. The lack of CAROTENOID ISOMERISATION generated a signal that rate-limited chlorophyll accumulation, but not phytoene biosynthesis in young Arabidopsis leaves exposed to a long photoperiod. Findings generated using this new foliar pigment bioassay implicate that carotenoid isomerisation and NFZ elicit different signalling pathways to control chlorophyll homeostasis in young emerging leaves.