bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of ranolazine on exercise tolerance and arrhythmias in patients with INOCA
Authors: Tseluyko Vira , Pylova Tetyana 
Published: October 2021

The aim of the study to evaluate the effect of supplementation of basic therapy by ranolazine in patients with INOCA on exercise test parameters and Holter ECG monitoring.
Materials and methods. 53 patients with stable coronary heart disease were examined, including 18 men (33.9 %) and 35 (66 %) women, the average age of patients was 57 (±9.68) years. According to the results of coronary angiography all patients had non-obstructive coronary arteries. In addition to physical and laboratory examination, bicycle ergometry, Holter ECG monitoring and echocardiography were included in the examination of patients. Patients were divided into 2 groups: group I - patients who in addition to standard therapy received ranolazine at a dose of 1000 mg twice a day for 6 months, and group II patients with standard coronary heart disease therapy. After 6 months from the beginning of the observation an objective examination, echocardiography, exercise test, Holter ECG monitoring were repeated.
Results. The study found that patients receiving ranolazine in addition to standard therapy had a statistically significant increase in exercise duration after 6 months compared with baseline and group II. Before treatment in group I, the duration of the exercise test was 356.51±180.24s, and after treatment 414.32±142.10s (p=0.03). In group II, the duration of the test before treatment was 361.4±160.24 c, and after 380.5±152.2 s (p=0.15). It was also found that the duration of the test differed significantly in group I after treatment of patients from group II after treatment of patients with a standard treatment regimen (p=0.04). According to the results of Holter ECG monitoring in group I found a positive effect of ranolazine on the frequency of ventricular arrhythmias: before treatment n=1142 [30; 2012], after treatment n=729 [23; 1420], while in group II a significant difference between the number of extrasystoles before treatment and after not detected (n=1026 [17; 1920], n=985 [15; 1680], respectively) p=0.18.
Conclusions. The addition of ranolazine to the basic therapy of patients with non-obstructive coronary arteries disease helps to increase exercise tolerance (according to the loading stress test) and contributes to a significant reduction in the number of ventricular arrhythmias (according to Holter-ECG) compared with both baseline and group II
Current trends in the treatment of acetabular fractures (literature review)
Authors: Vyrva Oleg , Vatamanitsa Dmytro 
Published: October 2021

Acetabular fractures are known for their disabling outcomes, so the search for optimal treatment tactics is an actual problem for modern orthopedics and traumatology. Materials and methods. Randomized trials that reflect the results of acetabular fractures treatment depending on the method of treatment were analyzed. The literature was searched in the PubMed Central database. Hip joint is a complex two-component articulated system. Traumatic lesion of all elements of the joint creates the conditions for the development of a wide range of complications and secondary changes that must be taken into account at preoperative treatment. Aceta­bular fracture is an intra-articular injury, where the visualization methods have the prominent significance. Nowadays the treatment can be conservative and surgical. Surgical treatment can be divided into two areas: osteosynthesis and arthroplasty. Anatomical reposition and stable fixation of fragments, in the most of cases, is the key to a satisfactory functional result, but the development of post-traumatic changes in the joint nullifies the results of even perfect osteosynthesis, encourages repeated surgery and, finally, hip replacement. In recent years, primary arthroplasty has been successfully used to treat acetabular fractures, reducing inpatient and rehabilitation period, compared with osteosynthesis, preventing the possible development of secondary degenerative changes in the joint. Conclusions. Acute hip replacement is an effective treatment, however, the technical aspects of reliable fixation of the ace­tabular component of the implant are insufficiently substantiated and highlighted in actual literature and constitute significant research interest.
Stochastic Analysis of the Break-Even of the Enterprise
Authors: Belykh Vasiliy 
Published: October 2021

The break-even equation describes the relationship between the financial indicators of a company at various levels of production and sales. The processes that lead to their change are considered deterministic. In this paper, we present a mathematical model that complements the break-even analysis by including the uncertainty related to the operating activity of the company. The method is based on the description of the revenue generation process using the geometric stochastic motion model. In addition to that, to more accurately describe the impact of time we used the concept of the operational cycle.
The equations that we obtained allow us to describe the financial result as a difference in the mathematicalexpectations of profit and loss. This method presents the structure of the financial result in terms of possiblefavorable and unfavorable outcomes, including into the analysis the alternative scenarios of company’s development.
In addition to the theoretical research, we show to what extent the uncertainty of revenue affects the financial performance of a stable operating company. For this purpose, we consider the charts of the probability density functions of the parameters used in the break-even analysis which demonstrate the contribution of the random component on their magnitude.
We will see that the conclusions made with regard to the stochastic nature of the proceeds may differ significantly from the results of the break-even analysis performed on the basis of the assumption of the deterministic nature of the proceeding processes. Within the framework of this paper, the operation of a company is considered primarily from the position of a breakeven analysis. However, the equations that were obtained can be used to calculate the indicators that allow to assess the risks of operating activities. This is shown in the interpretation of the model in terms of the options and calculation of return on equity, taking into account the risk.
Clinical and electromyography characteristics of chemotherapy-induced polyneuropathy in children with acute lymphoblastic leukemia
Authors: Koryakina Oksana V. , Kovtun Olga P. , Sabitov Alebai U. , Pediatric Larisa G. , Mikhailovskya Svetlana I. , Repakova Anna V. 
Published: October 2021

Background. The Hemoblastoses are one of the urgent problems of oncohematology. Modern methods for the treatment of hemoblastoses have improved the prognosis significantly. However, the use of chemotherapy is accompanied by a high frequency of drug complications, including those associated with neurotoxicity. The addition of neurological symptoms to the main clinical picture of the disease significantly aggravates the patients condition, affects the prognosis and quality to life.
Aim. Compare clinical picture and neurophysiological signs of chemo-induced polyneuropathy in children with acute lymphoblastic leukemia.
Materials and methods. Neurological examination and electromyography (EMG), were conducted in 21 children aged 3 to 17 years in Regional Children Clinical Hospital of Yekaterinburg from 2019 to 2020.
Results. In the study group, the signs of peripheral polyneuropathy, were revealed in almost all patients receiving induction chemotherapy (95.2%) while clinical neurological symptoms were found in 25% patients. During a 4-month follow-up, all children with subclinical signs of peripheral nerve damage developed corresponding neurological symptoms. According to EMG, the number of patients with mixed polyneuropathy increased by 1.7 times. In every third child, the amplitude of the M-response and nerve conduction velocity, were decreased.
Conclusions. Therefore, neurophysiological examination should be performed at an early stage to identify high-risk groups for neurotoxic complications in children with acute lymphoblastic leukemia receiving chemotherapy as timely administration of therapeutic treatment is required.
Prevalence and pattern of oral and maxillofacial trauma in Chhattisgarh- A retrospective study
Authors: Batra Sushmita , Singhai Surabhi , Krishna B Pramod , Singh Rajdeep , Soni Sushant 
Published: October 2021

Maxillofacial trauma is any physical trauma to the facial region, commonly encountered by maxillofacial surgeons, and is often associated with high morbidity and so constitute quite a significant portion of the workload of the oral and maxillofacial surgeon. Maxillofacial injuries can occur as an isolated injury or may be associated with multiple injuries in other parts of the body. To assess the patterns, etiology, and treatment modalities of maxillofacial trauma in a teaching hospital in central India, over a 12-year period. Patients with maxillofacial trauma were identified using the department database and clinical records. 264 patients were identified with maxillofacial trauma in the department of oral and maxillofacial surgery between January 2006 and December 2018. The study showed that there was a male preponderance in all age groups over female. Of the 264 patients with maxillofacial injuries, 83,33% had isolated lower face (mandibular) fractures, followed by midface fractures (10.60%) and panfacial fractures (6.06%). Road traffic accidents (87.12%) were the most common form of etiology for trauma followed by assaults (10.98%). Most trauma were treated with open reduction internal fixation (89%) than closed reduction (11%). The etiology and pattern of maxillofacial injuries reflect the trauma patterns within the community and can thus provide a guide to help design programs toward prevention and treatment.
MECHANISM FOR NEUTRALIZING INTERNAL AND EXTERNAL THREATS TO THE FINANCIAL SECURITY
Authors: Zhyvko Z. , Senyshyn O. , Rushchyshyn N. , Kukharska L. , Drymalovska Kh. 
Published: October 2021

Abstract. The main purpose of the article is to form a consistent and clear mechanism for neutralizing internal and external threats to financial security. Financial security at any level always implies a state of security against the impact of threats. Terms such as «risk», «call» and «danger» are often used. The article establishes the essence of the concepts of «financial security of higher education institution», «danger», «risk», «challenge» and «threat». Classification of threats into internal and external ones is carried out, their sources and factors are identified. The methods used to assess risks, their advantages and disadvantages are defined. It is offered to carry out an estimation of risks of financial security of higher education institutions by means of SWOT-analysis and expert methods, and using point marks to establish a generalized estimation of one expert of influence of factors of strong and weak sides of activity of higher education institution on assistance to use of possibilities and protection against threats taking into account probability of their occurrence. The generalized result of activity of higher educational institutions is calculated, which showed insignificant prevalence of internal strong factors in activity of higher educational institutions on quality of educational services provided by them and provision of financial security. Weaknesses of activity of higher education institutions on which management of quality of educational services for the purpose of maintenance of financial security should be focused, and also those strong sides of activity which potential should be used for achievement of the set goal are established. Based on the results of the study, it was identified the main weaknesses that the management of the quality of educational services should pay attention to in order to ensure the financial security of higher education institutions. It is necessary to take into account that the results of this assessment are quite variable in time, because according to the circumstances may change the system of factors, and step their influence. According to the results of the analysis, the most significant factors of internal and external environment of the institution of higher education were identified, and the matrix of components of the SWOT-analysis will take shape.
Keywords: financial security, threats, higher education institutions, education, risk.
JEL Classification B26, G29, I22, P43
Formulas: 3; fig.: 0; tabl.: 1; bibl.: 15.
PERSONAL INCOME TAX GAPS: BIBLIOMETRIC AND ECONOMETRIC ANALYSIS
Authors: Tiutiunyk I. , Mazurenko O. 
Published: October 2021

Abstract. The article is devoted to the essence and features of the formation of personal income tax gaps. The object of the paper is 1795 publications indexed in the Scopus database on the tax gaps in the national economy. The time horizon of the study was in 1935—2021. On the basis of bibliometric analysis, the main directions of the study of tax gaps are determine, the trend of changing the number of publications on this issue is analyzed. It is concluded that the theory of tax gap management is quite young and is currently only in its infancy. By the VOSViewer tools, five patterns of frequency of use of keywords in scientific works devoted to the issues of forming tax gaps have been identified, their connection with other economic categories have been determined. The analysis of the publications indexed in the Scopus database on a geographical basis is carried out. Clustering international research networks based on bibliometric analysis of scientific papers on the theory of tax gaps management by geographical location have been done. The article identifies the top Scientific Journals indexed by the Scopus database in which the issues of tax gap management were published most often. According to the Scopus database the most popular theories within this problem are: social theories, inequality and tax morality, management and motivation theories, sustainable development theory, production theory, concepts of fiscal policy implementation. A methodical approach to the assessment of tax gaps for personal income tax is proposed. The personal income tax gaps for Ukraine and European Union countries has been estimated. An average volume of personal income tax gaps within 7—28 %, and there is no positive dynamics in its reducing. The countries with the highest volume of personal income tax gaps include Greece, Poland, the Slovak Republic, Turkey, with the lowest — Germany, Belgium, Latvia, Luxembourg. Based on the Multiple regressions test, the hypothesis about the significant impact of tax gaps on personal income tax on the country’s economic development indicators was tested. Graphical interpretation of the link between the personal income tax gap and GDP for Ukraine and European Union countries indicates a negative correlation between them.
Keywords: tax gap, shadow economy, tax evasion, GDP, economic development, state policy.
JEL Classification E60, E63, C23
Formulas: 1; fig.: 4; tabl.: 2; bibl.: 17.
ASSESSMENT OF THE LEVEL OF ECONOMIC SECURITY OF INNOVATIVELY ACTIVE ENTERPRISES AS THE BASIS OF THE MANAGEMENT PROCESS WITHIN THE FINANCIAL AND LEGAL FIELD
Authors: Litvin N. , Grabar N. , Tymofeev S. , Harasym P. , Myshchyshyn O. 
Published: October 2021

Abstract. Today, in the current conditions of enterprise management, it is relevant to build and implement an effective economic security management system in the enterprise’s activities. Accordingly, as a control element, it is necessary to highlight the value of assessing the level of economic security in order to make the company’s specialists successful management decisions. Under the influence of momentary changes in management, it is problematic to select the theoretical and methodological foundations that will be used in such an element of enterprise management, including economic security, as an assessment. Some parameters that are obtained when assessing the level of economic security of an enterprise do not take into account all important aspects of activities. The main goal is to assess the level of economic security of innovatively active enterprises as the basis of the management process within the financial and legal field. The expediency of applying the Solow model to determine the level of economic security of innovatively active enterprises, based on the use of such quantitative indicators as the available labor resources, production assets, the volume of investment in innovation, the volume of non-productive consumption and the final product, is proposed and substantiated. The use of this technique allows us to conclude about the importance of resource provision and the dominant influence of the provision of labor resources to innovatively active enterprises. The research methodology assumes that at the present stage, the assessment of the level of economic security of enterprises is carried out using various methods and techniques. Agreeing with the permanent approaches proposed by economists, we propose to adapt to the system of methods for assessing the economic security of enterprises a method based on the use of the Solow model, the essence of which is that the economic security of an enterprise is considered as a whole economic phenomenon.
Keywords: economic security, innovatively active enterprises, management process, financial and legal field
JEL Classification B49, C10, C13, M20
Formulas: 5; fig.: 0; tabl.: 1; bibl.: 15.
INNOVATIVE DEVELOPMENT MANAGEMENT NETWORK ENTERPRISES IN THE CONTEXT OF INCREASING THE EFFICIENCY OF FINANCIAL AND ECONOMIC ACTIVITY
Authors: Petrova I. , Viktorov B. , Zakharchyn G. , Bondarchuk N. , Melnyk T. 
Published: October 2021

Abstract. For the network enterprises under research, the acquisition, organization of application of technologies, programmes, equipment which will improve economic, market, technical indicators, will provide the possibility to increase the general level of innovation has been suggested. To ensure the optimal selection, the use of innovative platforms for the selection of technologies, programmes, equipment has been proposed. Its application provides the possibility to identify the needs of innovative development of each of the enterprises under research and to develop individualized areas of innovation. The purpose of the article is to identify key problems of innovative development of Ukrainian network enterprises and to develop ways to improve its management on the basis of promising technologies. The methodology of assessing the state of innovative development of enterprises on the basis of four groups of indicators, namely the financial ones, the impact of innovative capacity on the level of international business development, staff composition, and logistics system, which has been implemented for five network structures on their primary information base, is presented. The expediency of adapting the Polish experience regarding the use of an innovative selection platform, which provides simulation modelling of the implementation of technologies and programmes, to the conditions and features of Ukrainian networks has been proved. Only network enterprises and their management system and innovative development were considered. The use of algorithms for commercialization of technologies, software that will allow the staff of research units of network structures to identify individualized needs of innovative development and develop individualized areas of innovation of the network structure, thus ensuring greater efficiency of innovation has been proposed. The results of the assessment made it possible to identify the main problems of innovation in network enterprises.
Keywords: innovative development, simulation modelling, intellectualization, network interaction, network enterprises.
JEL Classification O31, O32
Formulas: 0; fig.: 4; tabl.: 2; bibl.: 15.
THEORETICAL СONСEPTUАLІZАTІON OF BАNKІNG RІSK MАNАGEMENT
Authors: Kuzmak O. , Kuzmаk O. , Bіlyk V. 
Published: October 2021

Abstract. The article explore the theoretical aspects of banking risk management, its purpose, objects, subjects and advantages are singled out. Effective banking risk management should be considered as the main task of banking institutions in their development. From this research of theoretical foundations of banking risk management, we consider it а new direction of scientific research in Ukraine, so the theoretical and methodological developments of these problems are relevant today. In order to solve these problems, we propose to distinguish between «management of banking risks» and «banking risk management». In the research of the theoretical foundations of banking risk management, the interpretation of these basic concepts was proposed. Consequently, the authors proposed defined «management of banking risks» as a process that includes methods and techniques for identifying, assessing, monitoring, controlling and forecasting bank risks, in order to achieve the main objectives of the banks. And «banking risk management» defined as а set of principles, means and forms of management of the bank’s activities related to risks. For the development of the theory of banking risk management the authors proposed identified and characterized his subjects and objects. It is determined that the object is risks of banks and economic relations at risk, and the subject is the employees of the structural units, which, through the application of knowledge, skills, information and financial resources, participate in the management of banking risks. In addition, the advantages of effective risk management in the activities of banks are determined. The lack of research on the theoretical aspects of banking risk management can lead to deepening of theoretical and methodological problems and may negatively affect in the practical activities of banks.
Keywords: management of banking risks, banking risk management, bank, subjects and objects of banking risk management.
JEL Classification G21, G28
Formulas: 0; fig.: 1; tabl.: 0; bibl.: 12.
ВІЙСЬКОВОПОЛОНЕНІ НА ПІДПРИЄМСТВАХ ЦУКРОВОЇ ПРОМИСЛОВОСТІ ЧЕРНІГІВСЬКОЇ ГУБ. В РОКИ ПЕРШОЇ СВІТОВОЇ ВІЙНИ
Authors: Степанова О. 
Published: October 2021

Стаття присвячена аналізові проблеми використання праці військовополонених у цукровій промисловості Чернігівської губ. в період від початку Першої світової війни до Жовтневого перевороту. На основі архівних джерел проаналізовано стан промисловості та визначено фактори появи в ній негативних тенденцій. Особливу увагу приділено розгляду законодавства, що регулювало правове становище та умови утримання військовополонених.
Ключові слова: військовополонені, Перша світова війна, цукрова промисловість, Чернігівська губернія, економічна криза.
РОЛЬ ВЕЛИКОЇ БРИТАНІЇ У СТАНОВЛЕННІ ЗОВНІШНЬОЇ І БЕЗПЕКОВОЇ ПОЛІТИКИ ЄВРОПЕЙСЬКОГО СОЮЗУ (1990–2019 РР.)
Authors: Грубінко А. В. 
Published: October 2021

У статті представлено результати дослідження історичної ролі та особливостей участі Великої Британії у формуванні й реалізації Спільної зовнішньої та безпекової політики Європейського Союзу. Сформульовано висновок про те, що можливості СПБО ЄС приваблювали керівництво Великої Британії, але поглиблення її участі в інтеграції стримували усталені принципи зовнішньої політики. Керівництво держави різних періодів знехтувало об’єктивними можливостями її лідерства в ЄC у сфері зовнішньої і безпекової політики. Загалом Великій Британії не вдалося віднайти свого місця в європейському об’єднанні, логічним наслідком чого став Brexit та вихід держави з Європейського Союзу.
Keywords: Велика Британія, європейська інтеграція, Європейський Союз, Спільна зовнішня політика і політика безпеки, Спільна політика безпеки та оборони, Brexit, Україна.