bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text operators as dialogical mechanisms in judgments of the French Court of Cassation
Authors: Dolata-Zaród Anna 
Published: June 2021

AbstractThe aim of this article is to present text markers as a dialogical mechanism in the French language used in a legal setting. The dialogue between the court and the public administration takes place primarily through a judgment’s justification. On the other hand, the dialogue between the authorities and the court takes place in two possible variants: as a response to the parties allegations raised in the complaint or cassation complaint or as arguments formulated in the cassation complaint. Analyzing the decisions issued by the FrenchCour de cassation, one may notice that this material is characterized by three aspects: intentional, conventional and institutional, as it refers to a set of established beliefs about the nature of the world of a given community.
The question-response system in Mandarin conversation
Authors: Wang Wei 
Published: June 2021

AbstractThis article provides an overview of the question-response system in Mandarin Chinese from a conversation analytic perspective. Based on 403 question-response sequences from natural conversations, this study discusses the grammatical coding of Mandarin questions, social actions accomplished by questions, and formats of responses. It documents three grammatical types of questions, that is, polar questions (including sub-types), Q-word questions, and alternative questions. These questions are shown to perform a range of social actions, confirmation request being the most frequent. Also, this article reveals that the preferred format for confirming polar answers is interjection, while that for disconfirming polar answers is repetition. It provides a starting point for future studies on Mandarin questions and responses as well as a reference point for further crosslinguistic comparison.
LO And: an A-subtype contact binary with a very cool third component
Authors: Huang Hui-Ping , Yu Yun-Xia , Yu Ting , Hu Ke , Xiang Fu-Yuan 
Published: June 2021

Abstract
Despite the intensive investigations since the discovery of LO And approximately 60 yr ago, its evolutionary status and subtype are still a matter of controversy. By simultaneously modeling the radial-velocity curves and new light curves with the Wilson-Devinney code, we present new geometric, photometric and absolute parameters for this system. The simultaneous solution suggests that LO And is an A-subtype contact binary with a contact degree of 32.4%. The absolute parameters are modified to become M
1 = 1.409 M
⊙, M
2 = 0.449 M
⊙, R
1 = 1.36 R
⊙ and R
2 = 0.83 R
⊙. From our observations and data from surveys, we determined 334 eclipse timings. The O – C diagram, constructed from the new eclipse timings and those reported in the literature, reveals a secular increase and a cyclic variation in its orbital period. The former is caused by conservative mass transfer from the secondary component with less mass to the primary one with more mass. The latter may be explained by either the cyclic magnetic activity on the two components or the light-time effect due to a third body. With the absolute physical parameters, we investigated its evolutionary status, and find that LO And is an unevolved contact binary undergoing thermal relaxation oscillation, which will eventually coalesce into a single star with rapid rotation.
Generating and detecting bound entanglement in two-qutrits using a family of indecomposable positive maps
Authors: Bhattacharya Bihalan , Goswami Suchetana , Mundra Rounak , Ganguly Nirman , Chakrabarty Indranil , Bhattacharya Samyadeb , Majumdar A S 
Published: June 2021

Abstract
The problem of bound entanglement detection is a challenging aspect of quantum information theory for higher dimensional systems. Here, we propose an indecomposable positive map for two-qutrit systems, which is shown to detect a class of positive partial transposed (PPT) states. A corresponding witness operator is constructed and shown to be weakly optimal and locally implementable. Further, we perform a structural physical approximation of the indecomposable map to make it a completely positive one, and find a new PPT-entangled state which is not detectable by certain other well-known entanglement detection criteria.
Emergence of transient chaos and intermittency in machine learning
Authors: Kong Ling-Wei , Fan Huawei , Grebogi Celso , Lai Ying-Cheng 
Published: June 2021

Abstract
An emerging paradigm for predicting the state evolution of chaotic systems is machine learning with reservoir computing, the core of which is a dynamical network of artificial neurons. Through training with measured time series, a reservoir machine can be harnessed to replicate the evolution of the target chaotic system for some amount of time, typically about half dozen Lyapunov times. Recently, we developed a reservoir computing framework with an additional parameter channel for predicting system collapse and chaotic transients associated with crisis. It was found that the crisis point after which transient chaos emerges can be accurately predicted. The idea of adding a parameter channel to reservoir computing has also been used by others to predict bifurcation points and distinct asymptotic behaviors. In this paper, we address three issues associated with machine-generated transient chaos. First, we report the results from a detailed study of the statistical behaviors of transient chaos generated by our parameter-aware reservoir computing machine. When multiple time series from a small number of distinct values of the bifurcation parameter, all in the regime of attracting chaos, are deployed to train the reservoir machine, it can generate the correct dynamical behavior in the regime of transient chaos of the target system in the sense that the basic statistical features of the machine generated transient chaos agree with those of the real system. Second, we demonstrate that our machine learning framework can reproduce intermittency of the target system. Third, we consider a system for which the known methods of sparse optimization fail to predict crisis and demonstrate that our reservoir computing scheme can solve this problem. These findings have potential applications in anticipating system collapse as induced by, e.g., a parameter drift that places the system in a transient regime.
Enacting a Jazz Beat: Temporality in Sonic Environment and Symbolic Communication
Authors: Solli Mattias , Netland Thomas 
Published: June 2021

AbstractWhat does it mean to enact a jazz beat as a creative performer? This article offers a critical reading of Iyer’s much-cited theory on rhythmic enaction. We locate the sonic environment approach in Iyer’s theory, and criticize him for advancing a one-to-one relationship between everyday perception and full-fledged aural competence of jazz musicians, and for comparing the latter with non-symbolic behaviour of non-human organisms. As an alternative, we suggest a Merleau-Ponty-inspired concept of rhythmic enaction, which we call the enactive communicative approach. Key to this approach is the fact that jazz musicians play by ear, and that the beat emerges because of reciprocal, real-time aural communication. From this perspective, we outline the temporality of a jazz beat as a holistic and dialectical temporal structure. Throughout the discussions, we use John Coltrane’s ‘Trane’s Slo Blues’ as a point of reference.
The dispersal-related traits of an invasive plant Galinsoga quadriradiata correlate with elevation during range expansion into mountain ranges
Authors: Liu Rui-Ling , Yang Ying-Bo , Lee Benjamin R , Liu Gang , Zhang Wen-Gang , Chen Xiao-Yan , Song Xing-Jiang , Kang Ju-Qing , Zhu Zhi-Hong 
Published: June 2021

Abstract
Detecting shifts in trait values among populations of an invasive plant is important for assessing invasion risks and predicting future spread. Although a growing number of studies suggest that the dispersal propensity of invasive plants increases during range expansion, there has been relatively little attention paid to dispersal patterns along elevational gradients. In this study, we tested the differentiation of dispersal-related traits in an invasive plant, Galinsoga quadriradiata, across populations at different elevations in the Qinling and Bashan Mountains in central China. Seed mass–area ratio (MAR), an important seed dispersal-related trait, of 45 populations from along an elevational gradient was measured, and genetic variation of 23 populations was quantified using inter-simple sequence repeat (ISSR) markers. Individuals from four populations were then planted in a greenhouse to compare their performance under shared conditions. Changing patterns of seed dispersal-related traits and populations genetic diversity along elevation were tested using linear regression. Mass–area ratio of G. quadriradiata increased, while genetic diversity decreased with elevation in the field survey. In the greenhouse, populations of G. quadriradiata sourced from different elevations showed a difference response of MAR. These results suggest that although rapid evolution may contribute to the range expansion of G. quadriradiata in mountain ranges, dispersal-related traits will also likely be affected by phenotypic plasticity. This challenges the common argument that dispersal ability of invasive plants increases along dispersal routes. Furthermore, our results suggest that high-altitude populations would be more effective at seed dispersal once they continue to expand their range downslope on the other side. Our experiment provides novel evidence that the spread of these high-altitude populations may be more likely than previously theorized and that they should thus be cautiously monitored.
Efficient production of the rare sugar l-gulose using a wheat-bran culture extract of Penicillium sp. KU-1
Authors: Kuroishikawa Takayuki , Yoshihara Akihide , Furuta Itsumi , Mochizuki Susumu , Watanabe Akira , Izumori Ken , Asada Yasuhiko 
Published: June 2021

ABSTRACT
We found that l-gulose, a rare sugar, was produced from d-sorbitol efficiently, using a wheat-bran culture extract of the fungus Penicillium sp. KU-1 isolated from soil. The culture extract showed enzyme activity for the oxidation of d-sorbitol to produce l-gulose; a high production yield of approximately 94% was achieved.
Analysis of the light regulatory mechanism in carotenoid production in Rhodosporidium toruloides NBRC 10032
Authors: Pham Khanh Dung , Hakozaki Yuuki , Takamizawa Takeru , Yamazaki Atsushi , Yamazaki Harutake , Mori Kazuki , Aburatani Sachiyo , Tashiro Kosuke , Kuhara Satoru , Takaku Hiroaki , Shida Yosuke , Ogasawara Wataru 
Published: June 2021

ABSTRACT
Light stimulates carotenoid production in an oleaginous yeast Rhodosporidium toruloides NBRC 10032 by promoting carotenoid biosynthesis genes. These genes undergo two-step transcriptional activation. The potential light regulator, Cryptochrome DASH (CRY1), has been suggested to contribute to this mechanism. In this study, based on KU70 (a component of nonhomologous end joining (NHEJ)) disrupting background, CRY1 disruptant was constructed to clarify CRY1 function. From analysis of CRY1 disruptant, it was suggested that CRY1 has the activation role of the carotenogenic gene expression. To obtain further insights into the light response, mutants varying carotenoid production were generated. Through analysis of mutants, the existence of the control two-step gene activation was proposed. In addition, our data analysis showed the strong possibility that R. toruloides NBRC 10032 is a homo-diploid strain.
VoroContacts: a tool for the analysis of interatomic contacts in macromolecular structures
Authors: Olechnovič Kliment , Venclovas Česlovas 
Published: June 2021

Abstract

Summary
VoroContacts is a versatile tool for computing and analyzing contact surface areas (CSAs) and solvent accessible surface areas (SASAs) for three-dimensional (3D) structures of proteins, nucleic acids and their complexes at the atomic resolution. CSAs and SASAs are derived using Voronoi tessellation of 3D structure, represented as a collection of atomic balls. VoroContacts web server features a highly configurable query interface, which enables on-the-fly analysis of contacts for selected set of atoms and allows filtering interatomic contacts by their type, surface areas, distance between contacting atoms and sequence separation between contacting residues. The VoroContacts functionality is also implemented as part of the standalone Voronota package, enabling batch processing.

Availability and implementation
https://bioinformatics.lt/wtsam/vorocontacts.

Supplementary information
Supplementary data are available at Bioinformatics online.
Differing Alterations of Odor Volatiles Among Pathogenic Stimuli
Authors: Millet Patrick , Martin Talia , Opiekun Maryanne , Beauchamp Gary K , Kimball Bruce A 
Published: June 2021

Abstract
Alterations of the volatile metabolome (the collection of volatiles present in secretions and other emanations) that occur in response to inflammation can be detected by conspecifics and chemometric analyses. Using a model system where mouse urinary metabolites are altered by treatment with lipopolysaccharide (found in the outer cell membrane of gram-negative bacteria), we hypothesized that alteration of body odor volatiles will vary according to the pathogen responsible for inducing the inflammation. We tested this hypothesis by treating mice with different immunogens that engage different immune signaling pathways. Results suggest that alterations of body odor volatiles resulting from inflammation do contain detailed information about the type of pathogen that instigated the inflammation and these differences are not merely dependent on the severity of the inflammatory event. These results are encouraging for the future of differential medical diagnosis of febrile diseases by analysis of the volatile metabolome. In particular, our data support the possibility that bacterial infections can be differentiated from viral infections such that antibiotic drug stewardship could be drastically improved by reducing unneeded treatments with antibiotics.
Variance-component-based meta-analysis of gene–environment interactions for rare variants
Authors: Jin Xiaoqin , Shi Gang 
Published: June 2021

Abstract
Complex diseases are often caused by interplay between genetic and environmental factors. Existing gene–environment interaction (G × E) tests for rare variants largely focus on detecting gene-based G × E effects in a single study; thus, their statistical power is limited by the sample size of the study. Meta-analysis methods that synthesize summary statistics of G × E effects from multiple studies for rare variants are still limited. Based on variance component models, we propose four meta-analysis methods of testing G × E effects for rare variants: HOM-INT-FIX, HET-INT-FIX, HOM-INT-RAN, and HET-INT-RAN. Our methods consider homogeneous or heterogeneous G × E effects across studies and treat the main genetic effect as either fixed or random. Through simulations, we show that the empirical distributions of the four meta-statistics under the null hypothesis align with their expected theoretical distributions. When the interaction effect is homogeneous across studies, HOM-INT-FIX and HOM-INT-RAN have as much statistical power as a pooled analysis conducted on a single interaction test with individual-level data from all studies. When the interaction effect is heterogeneous across studies, HET-INT-FIX and HET-INT-RAN provide higher power than pooled analysis. Our methods are further validated via testing 12 candidate gene–age interactions in blood pressure traits using whole-exome sequencing data from UK Biobank.
The Early Impact of the IDEA Collaboration Results: How the Results Changed Prescribing Practice
Authors: Iveson Timothy , Hanna Catherine , Iveson Poppy , Zhang Sui , Levasseur Alexandra , Meyerhardt Jeffrey 
Published: June 2021

Abstract

Background
Traditionally, adjuvant treatment for colon cancer has been 6 months of combination chemotherapy. Six phase III trials tested the hypothesis that 3 months is noninferior in efficacy to 6 months and reduces long-term side effects for patients. The results were pooled in the International Duration Evaluation of Adjuvant therapy (IDEA) collaboration. Although this did not meet the noninferiority endpoint, a preplanned subgroup analysis by chemotherapy regimen did demonstrate noninferiority for capecitabine and oxaliplatin. Additionally, risk stratification by T and N stage was defined.

Methods
In an effort to understand the real-life impact of these results, 4 months after the IDEA results, an online survey was distributed to clinicians to ask their approach to the adjuvant treatment of patients with stage III colon cancer.

Results
The survey was completed by 458 clinicians from 12 countries. Assuming that 6 months of treatment was the pretrial standard of care, 89.5% of clinicians reported they had changed practice to prescribe 3 months of treatment for some patients. For patients with low-risk stage III disease, there was a preference for 3 months, and for patients with high-risk stage III disease, most clinicians still prescribed 6 months at that time. Overall, capecitabine and oxaliplatin regimen was the most popular. There were important differences in responses depending on the location of respondent and T and N stage of disease.

Conclusion
This survey shows that the IDEA collaboration has been practice changing but reveals important differences in the way results are interpreted by individual clinicians.
NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs
Authors: Qureshi Nusrat Shahin , Matzel Tobias , Cetiner Erhan Can , Schnieders Robbin , Jonker Hendrik R A , Schwalbe Harald , Fürtig Boris 
Published: June 2021

Abstract
The ribosomal S1 protein (rS1) is indispensable for translation initiation in Gram-negative bacteria. rS1 is a multidomain protein that acts as an RNA chaperone and ensures that mRNAs can bind the ribosome in a single-stranded conformation, which could be related to fast recognition. Although many ribosome structures were solved in recent years, a high-resolution structure of a two-domain mRNA-binding competent rS1 construct is not yet available. Here, we present the NMR solution structure of the minimal mRNA-binding fragment of Vibrio Vulnificus rS1 containing the domains D3 and D4. Both domains are homologues and adapt an oligonucleotide-binding fold (OB fold) motif. NMR titration experiments reveal that recognition of miscellaneous mRNAs occurs via a continuous interaction surface to one side of these structurally linked domains. Using a novel paramagnetic relaxation enhancement (PRE) approach and exploring different spin-labeling positions within RNA, we were able to track the location and determine the orientation of the RNA in the rS1–D34 bound form. Our investigations show that paramagnetically labeled RNAs, spiked into unmodified RNA, can be used as a molecular ruler to provide structural information on protein-RNA complexes. The dynamic interaction occurs on a defined binding groove spanning both domains with identical β2-β3-β5 interfaces. Evidently, the 3′-ends of the cis-acting RNAs are positioned in the direction of the N-terminus of the rS1 protein, thus towards the 30S binding site and adopt a conformation required for translation initiation.
Telehealth and Rural-Urban Differences in Receipt of Pain Care in the Veterans Health Administration
Authors: Chen Jessica A , DeFaccio Rian J , Gelman Hannah , Thomas Eva R , Indresano Jess A , Dawson Timothy C , Glynn Lisa H , Sandbrink Friedhelm , Zeliadt Steven B 
Published: June 2021

Abstract

Objective
Examine changes in specialty pain utilization in the Veterans Health Administration (VHA) after establishing a virtual interdisciplinary pain team (TelePain).

Design
Retrospective cohort study.

Setting
A single VHA healthcare system, 2015–2019.

Subjects
33,169 patients with chronic pain-related diagnoses.

Methods
We measured specialty pain utilization (in-person and telehealth) among patients with moderate to severe chronic pain. We used generalized estimating equations to test the association of time (pre- or post-TelePain) and rurality on receipt of specialty pain care.

Results
Among patients with moderate to severe chronic pain, the reach of specialty pain care increased from 11.1% to 16.2% in the pre- to post-TelePain periods (adjusted odds ratio [aOR]: 1.37, 95% confidence interval [CI]: 1.26–1.49). This was true of both urban patients (aOR: 1.62, 95% CI: 1.53–1.71) and rural patients (aOR: 1.16, 95% CI: 0.99–1.36), although the difference for rural patients was not statistically significant. Among rural patients who received specialty pain care, a high percentage of the visits were delivered by telehealth (nearly 12% in the post-TelePain period), much higher than among urban patients (3%).

Conclusions
We observed increased use of specialty pain services among all patients with chronic pain. Although rural patients did not achieve the same degree of access and utilization overall as urban patients, their use of pain telehealth increased substantially and may have substituted for in-person visits. Targeted implementation efforts may be needed to further increase the reach of services to patients living in areas with limited specialty pain care options.
Tetraphenylethylene-conjugated polycation covered iron oxide nanoparticles for magnetic resonance/optical dual-mode imaging
Authors: Yang Li , Fu Shengxiang , Liu Li , Cai Zhongyuan , Xia Chunchao , Song Bin , Gong Qiyong , Lu Zhiyun , Ai Hua 
Published: June 2021

Abstract
Magnetic resonance (MR)/optical dual-mode imaging with high sensitivity and high tissue resolution have attracted many attentions in biomedical applications. To avert aggregation-caused quenching of conventional fluorescence chromophores, an aggregation-induced emission molecule tetraphenylethylene (TPE)-conjugated amphiphilic polyethylenimine (PEI) covered superparamagnetic iron oxide (Alkyl-PEI-LAC-TPE/SPIO nanocomposites) was prepared as an MR/optical dual-mode probe. Alkyl-PEI-LAC-TPE/SPIO nanocomposites exhibited good fluorescence property and presented higher T2 relaxivity (352 Fe mM−1s−1) than a commercial contrast agent Feridex (120 Fe mM−1s−1) at 1.5 T. The alkylation degree of Alkyl-PEI-LAC-TPE effects the restriction of intramolecular rotation process of TPE. Reducing alkane chain grafting ratio aggravated the stack of TPE, increasing the fluorescence lifetime of Alkyl-PEI-LAC-TPE/SPIO nanocomposites. Alkyl-PEI-LAC-TPE/SPIO nanocomposites can effectively labelled HeLa cells and resulted in high fluorescence intensity and excellent MR imaging sensitivity. As an MR/optical imaging probe, Alkyl-PEI-LAC-TPE/SPIO nanocomposites may be used in biomedical imaging for certain applications.
Is specific jurisdiction dead and did we murder it? An appraisal of the Brussels Ia Regulation in the globalizing context of the HCCH 2019 Judgments Convention
Authors: Poesen Michiel 
Published: June 2021

Abstract
Specific jurisdiction in the European Union (EU) is in a state of flux. While its theoretical foundation varies among legal systems, the explanatory model in EU law—established by the Brussels Ia Regulation—is the close geographical connection between a dispute’s subject matter and a court. It is believed that the court with such a connection is best positioned to judge the matter. Therefore, Article 7 of the Brussels Ia Regulation allocates jurisdiction over subject matters as broadly defined as contracts and torts to the court of an array of predetermined locations. However, in reality the courts so identified will not always have a close connection to the dispute. Nonetheless, the court of that place has jurisdiction. This article will evaluate the legitimacy of denying a more concrete role to the linkage between a forum and a dispute. It will also contrast the current state of play in the EU with the approach taken in the jurisdictional filters featuring in the 2019 Hague Judgments Convention.