bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis
Authors: Chen Xi , Hou Yulong , Chen Can , Jiang Guan 
Published: January 2021

IntroductionBasal cell carcinoma (BCC) located on the genitalia is rare; data on the clinicopathologic features and survival outcomes are only available through case reports and small case series studies.PurposeThis study aimed to explore the epidemiology and identify the prognostic factors of genital BCCs.MethodsWe queried the 18 registries of the Surveillance, Epidemiology, and End Results database for patients with primary BCCs of the genital skin from 2000 through 2017. The primary endpoint was overall survival (OS) and disease specific survival (DSS). Kaplan-Meier survival analysis was conducted to assess the impact of clinicopathological variables on OS and DSS. Multivariate Cox proportional hazards model was performed to evaluate risk factors for OS.ResultsA total of 1,607 cases of genital BCCs were identified. The cohort was composed of 1,352 women (84.1%) and 255 men (15.9%). The median (P25, P75) age of the entire cohort was 73(63–82)years. White patients accounted for 87.2% of the cases. For women and men, the most common site of involvement was the labia majora (89.6%) and scrotum (74.5%), respectively. The majority of patients with genital BCC had localized disease (75.5%). Kaplan-Meier survival analysis showed that female genital BCCs experienced better DSS than men (209.1 months vs 194.8 months); for men, BCCs located on the scrotum had better DSS and OS than those on the penis (P &lt; 0.05 for both endpoints). All patients with distant disease died of disease-specific death, and the average survival time was 8.2 months. Multivariate analysis revealed that age, primary site, and stage were independent determinants of OS for men, while tumor size, histologic subtype, and race were not. For women, factors associated with worse OS included increasing age, tumor size more than 2 cm, and distant disease; factors associated with a decreased risk included “other” and “unknown” races.ConclusionThe prognosis of genital BCCs is excellent, while the survival of distant disease is very poor. Despite similar clinicopathologic features and overall survival outcomes, men and women should be treated as two different entities when making survival predictions.
Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials
Authors: Sun Yanli , Han Jie , Wang Zhanzhao , Li Xuening , Sun Yanhua , Hu Zhenbo 
Published: January 2021

Background: The upregulated expression of BET proteins is closely associated with the occurrence and development of hematological malignancies and solid tumors. Several BET inhibitors have been developed, and some have been in phase I/II of clinical trials. Here, the safety, efficacy, and pharmacodynamics of ten BET inhibitors currently in clinical trials were evaluated.Methods: We retrieved and reviewed published reports on the clinical trials of twelve BET inhibitors including AZD5153, ABBV-075, BMS-986158, CPI-0610, GSK525762, OTX-015, PLX51107, INCB054329, INCB057643, FT-1101, CC-90010, and ODM-207 for patients with hematological malignancies and solid tumors and summarized their published target genes.Results: In the monotherapy of BET inhibitors, the most common and severe (grade ≥3) hematological adverse events (AEs) are thrombocytopenia, anemia, and neutropenia. The most common non-hematological syndromes are diarrhea, nausea, fatigue, dysgeusia, and decreased appetite, while the most severe AE is pneumonia. Additionally, Tmax of these BET inhibitors was between 0.5–6 h, but the range for T1/2 varied significantly. According to published data, the rates of SD, PD, CR and PR were 27.4%, 37.6%, 3.5%, and 5.7%, respectively, which is not very satisfactory. In addition to BRD4, oncogene MYC is another common target gene of these BET inhibitors. Ninety-seven signaling pathways may be regulated by BET inhibitors.Conclusion: All BET inhibitors reviewed in our study exhibited exposure-dependent thrombocytopenia, which may limit their clinical application. Moreover, further efforts are necessary to explore the optimal dosing schemes and combinations to maximize the efficacy of BET inhibitors.
Age Dependence of Antimicrobial Resistance Among Fecal Bacteria in Animals: A Scoping Review
Authors: Gaire Tara N. , Scott Harvey Morgan , Sellers Laura , Nagaraja T. G. , Volkova Victoriya V. 
Published: January 2021

Introduction: A phenomenon of decreasing antimicrobial resistance (AMR) among fecal bacteria as food animals age has been noted in multiple field studies. We conducted a scoping review to summarize the extent, range, and nature of research activity and the data for the following question: “does AMR among enteric/fecal bacteria predictably shift as animals get older?”.Methods: This review followed a scoping review methodology framework. Pertinent literature published up until November 2018 for all animals (except humans) was retrieved using keyword searches in two online databases, namely, PubMed® and the Web of Science™ Core Collection, without filtering publication date, geographic location, or language. Data were extracted from the included studies, summarized, and plotted. Study quality was also assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) guidelines for all included papers.Results: The publications with detailed relevant data (n = 62) in food animals, poultry, and dogs were identified. These included longitudinal studies (n = 32), cross-sectional studies of different age groups within one food animal production system or small-animal catchment area (n = 16), and experimental or diet trials (n = 14). A decline in host-level prevalence and/or within-host abundance of AMR among fecal bacteria in production beef, dairy cattle, and swine was reported in nearly two-thirds (65%) of the identified studies in different geographic locations from the 1970's to 2018. Mixed results, with AMR abundance among fecal bacteria either increasing or decreasing with age, have been reported in poultry (broiler chicken, layer, and grow-out turkey) and dogs.Conclusions: Quantitative synthesis of the data suggests that the age-dependent AMR phenomenon in cattle and swine is observed irrespective of geographic location and specific production practices. It is unclear whether the phenomenon predates or is related to antimicrobial drug use. However, almost 50% of the identified studies predate recent changes in antimicrobial drug use policy and regulations in food animals in the United States and elsewhere.
DAIRY GOAT BREEDING IN RUSSIA AND ITS BREEDING BASE
Authors: ГРИГОРЯН Л.Н. , ХАТАТАЕВ С.А. , НОВОПАШИНА С.И. , ХМЕЛЕВСКАЯ Г.Н. , СТЕПАНОВА Н.Г. 
Published: January 2021

Изучено состояние молочного козоводства в РФ. На начало 2020 года в сельскохозяйственных организациях России числилось 36 тыс. коз молочных пород, среди которых доля животных зааненской породы составила 82,8%, альпийской — 14,5%, мурсиано гранадина — 1,3%, нубиан — 0,9%. Удой на 1 козоматку за 305 дней лактации составил в целом по зааненской породе 654 кг, в том числе в племенных организациях — 659 кг; по альпийской породе в подконтрольных организациях — 662 кг; нубиан — 832 кг. Козоматки зааненской породы племенных организаций превосходили минимальные требования к удою молока, предъявляемые к козам желательного типа по 1-й лактации на 6,3%, по 2 — на 18,2%, 3 и старше — на 23,1%. Превышение аналогичных требований к удою у коз альпийской породы 1, 2, 3 лактации и старше составило 20,9, 37,1 и 22,9%, соответственно. Удои коз от 1 до 3 лактации и старше существенно повышались: зааненской породы — на 65,5%, альпийской — на 45,2%. Высокие показатели молочной продуктивности достигнуты по зааненской породе в племзаводах АО ПЗ «Красноозерное» и ЗАО «ПЗ Приневское Ленинградской области (удой равен 846 и 838 кг молока), в племрепродукторах ООО «Березка» Курской области (852 кг), ООО «КХ «Русь-1» Ставропольского края (825 кг), ООО СП «Лукоз» Республики Мари
Progress in dairy goat breeding in Russia is studied. At the beginning of 2020 there were 36000 goats of dairy breeds on Russian farms. Proportion of Zaannensky breed is 82,8%, Alpine — 14,5%, Mursiana Granadina — 1,3%, Nubian — 0,9%. Yield per 1 female goat for 305 days of lactation is as follows: Zaannensky breed 654 kg, in cluding pedigree farms — 659 kg; Alpine breed on controlled farms — 662 kg; Nubian — 832 kg. Female goats of Zaannensky breed on pedigree farms surpass the minimum requirements to milk yield which are applied to goats of the desired type for the 1st lactation by 6,3%, for the 2nd — by 18,2%, for the 3d and older —by 23,1%. Surpass of the analogous requirements to yield of the Alpine goats of the 1, 2, 3 and older is 20,9, 37,1 and 22,9%. Yields of goats from the 1st to 3d and older lactations essentially raised: Zaannensky breed — by 65,5%, Alpine breed — by 45,2%. High merits of dairy productivity are achieved in Leningrad region on pedigree farms where they have Zaannensky breed (846—838 kg), on multiplying farms in Kursk region (852 kg), Stavropol region (825 kg), in Mari El Republic (767 kg); Alpine breed in Leningrad region (754 kg), in Moscow region (696 kg).
A metáfora no ensino: uma análise de seu potencial como recurso pedagógico em videoaulas do Youtube
Authors: Schabarum John Richart , Chishman Rove Luiza de Oliveira 
Published: January 2021

O presente artigo trata da ocorrência de metáforas conceptuais e de suas respectivas expressões metafóricas em videoaulas do YouTube, assim como apresenta avanços nas discussões e análises realizadas por Schabarum e Chishman (2020) nesse mesmo contexto. Nesse sentido, o objetivo geral do trabalho é averiguar o caráter pedagógico da emergência de metáforas em videoaulas. Para isso, tomamos como base os pressupostos teóricos de Cameron (1999, 2003) e Semino (2008). Do ponto de vista metodológico, esta pesquisa tem caráter qualitativo e conta, como corpus de pesquisa, com a transcrição de duas videoaulas de Biologia sobre sistema imunológico provenientes do YouTube. Foram adotados, como recursos metodológicos, um dicionário de termos de ciências biológicas e uma ferramenta de pesquisa em corpus eletrônico. Os resultados indicam que as metáforas conceptuais as expressões metafóricas por elas licenciadas são amplamente empregadas nas videoaulas analisadas e representam conceitos científicos com gradação e precisão distintas, já que as expressões metafóricas que representam nosso entendimento sobre conceitos científicos podem ser classificadas como técnicas, subtécnicas ou constitutivas de teoria, conforme postula Cameron (2003). Essas metáforas e expressões metafóricas apresentam, contudo, um ponto em comum: funcionam como recurso pedagógico eficiente.
Redobramento, recursão e verbos de movimento em português
Authors: Kewitz Verena 
Published: January 2021

Neste artigo apresento um dos padrões de representação do movimento em português, especificamente quando há redobramento da informação do percurso no verbo e em expressões preposicionadas ou adverbiais. Para tanto, retomo o conceito de redobramento sintático apresentado por Moraes de Castilho (2005, 2011), atrelado ao Princípio de Recursão da Abordagem Multissistêmica (CASTILHO 2015). Com base na Semântica Cognitiva, mais especificamente na proposta de Talmy (1985, 2000b), descrevo dados do português arcaico com alguns verbos de movimento (entrar, sair, subir etc.) em que se observa o redobramento da informação de percurso. Ao final, coloco algumas questões e encaminhamentos para pesquisas futuras.
A semântica do passado composto em português
Authors: Ilari Rodolfo 
Published: January 2021

Neste projeto, retomo um tema que foi objeto de uma comunicação apresentada no II Congresso Nacional de Linguística, realizado em 1983 na PUC do Rio de Janeiro. Naquela comunicação, eu centrei minhas atenções em dois problemas que se encontram na tentativa de formular em termos explícitos o papel semântico do Passado Composto, problemas que consistem, mais precisamente, 1) em formalizar seu sentido iterativo (que contrasta com o das demais perífrases “de tempo” construídas mediante o auxiliar ter, mas é normal para aquela forma quando o verbo de sentido pleno indica ação), e 2) em manter, nessa formulação, a possibilidade de relacionar o sentido iterativo com o sentido durativo que, embora menos comum, é possível quando o predicado indica estado.Na comunicação de 1983, esses dois problemas ou “desafios” vinham formulados com alguma clareza, mas pouco era feito no sentido de sua superação; por outro lado, aquele texto sugeria que tudo mais, na descrição semântica do passado composto português é questão de simples rotina, e isto é certamente falso. A existência de impasses reconhecidos, a possível existência de outros e uma atenção maior à maneira como os vários aspectos da significação do passado composto se articulam justificam a retomada do tema; o propósito, aqui, era o de chegar a uma descrição formal unificada e simples da semântica daquela forma; é possível que este trabalho faça menos do que isso, por exemplo porque as soluções aventadas para os vários problemas parciais não se juntam; é possível também que fique simplesmente ampliado o repertório de impasses.
Enhanced external quantum efficiency of III-nitride micro-light-emitting diodes using vertical and transparent package
Authors: Wong Matthew S. , Oh Sang Ho , Back Joonho , Lee Changmin , Speck James S. , Nakamura Shuji , DenBaars Steven P. 
Published: January 2021

Abstract
In this work, 40 × 40 μm2 blue InGaN micro-light-emitting diodes (μLEDs) with transparent and vertical package was first demonstrated by using either double-side polished zinc oxide (ZnO) or sapphire substrate as a transparent submount. The performance of the vertical and conventional packages was compared, where the devices packaged vertically resulted in smaller blueshift in peak wavelength with increasing drive current due to the higher junction temperature. Moreover, devices packaged vertically with the sapphire submount offered 19% and 32% greater light output power at 20 and 100 A cm−2, respectively, and 18% improvement in maximum external quantum efficiency (EQE) than devices with conventional package. Finally, the peak EQE of 58% was achieved from the μLED packaged vertically using a sapphire submount.
Space-charge-limited current with traps in trigonal selenium nanowires
Authors: Akiyama Norio , Dohi Tsukasa 
Published: January 2021

Abstract
The current–voltage (I–V) characteristics of trigonal selenium (t-Se) nanowire (NW) crystals made via immersion in ethanol have been studied. A steep increase in current at the trap-filled limit voltage is observed in the I–V curve of t-Se NWs with a space-charge-limited current. From an analysis of the I–V characteristics based on a three-dimensional model, the trap concentration and trap energy are estimated to be 6.8 × 1012 cm−3 and 0.60 eV, respectively. It is compared with trap levels of 0.59, 0.42, and 0.37 eV obtained from an analysis of the photocurrent spectrum of t-Se NWs, which can be attributed to the deformation, OH- stretching mode, and CH- stretching mode, respectively.
INTERTEXTUALITY AND POSTMODERNISM :THEORETICAL PERSPECTIVES OF THE PROBLEM IN MODERN LITERARY STUDIES
Authors: Илунина Анна Александровна 
Published: January 2021

В статье анализируются теоретические аспекты проблемы интертекстуальности. Предметом исследования являются труды, опубликованные с момента зарождения термина в работах М. М. Бахтина и Ю. Кристевой до конца ХХ - начала ХХ1 века, в которых отражено отношение современной филологической мысли к изучаемому феномену. Цель исследования - выявить основные этапы развития теории интертекстуальности, классифицировать наиболее значимые подходы к данному явлению, рассмотреть связь понятий интертекстуальности и постмодернизма. В результате исследования были выявлены широкий и узкий подходы в трактовке указанного понятия. Было уточнено, что интертекстуальность можно рассматривать как центральное понятие постмодернистской поэтики. Она может изучаться и в расширенном понимании как философская установка постмодерна и как художественный прием, сознательная писательская интенция на создание маркированных межтекстовых связей с работами предшественников и современников. Развитие теории интертекстуальности на современном этапе демонстрирует, что, хотя само понятие невозможно ограничить рамками только постмодернистской поэтики, изучение конкретных проявлений интертекстуальности в постмодернистской литературе представляет собой широкое поле для исследователя.
The article analyses some theoretical perspectives of intertextuality. The subject of the research is the works on intertextuality published since the origin of the term in the works of M. M. Bakhtin and Yu. Kristeva to the late 20th and early 21st centuries. Those works reflect modern approaches to the phenomenon of intertextuality in philological research. The purpose of the study is to identify the main stages of development of intertexuality theory, to classify the main approaches to the phenomenon of intertextuality, and consider the relation between the concepts of intertextuality and postmodernism. As a result of the study, there have been identified “broad” and “narrow” approaches to the concept of intertextuality. It was clarified that intertextuality can be considered as the central concept of postmodern poetics and the basis of postmodern writing. It can also be studied in broad understanding as a philosophical paradigm of postmodernism and as stylistic device, writer’s intention to create intertextual links with works of predecessors and contemporary writers. The development of the theory of intertextuality at the present stage demonstrates that, although the concept of intertextuality cannot be limited to postmodern poetics alone, the study of specific manifestations of intertextuality in postmodern literature is a broad field for researchers.
The Insect database in Dokdo, Korea: An updated version in 2020
Authors: Ryu Jihun , Kim Young-Kun , Suh Sang Jae , Choi Kwang Shik 
Published: January 2021

Dokdo, a group of islands near the East Coast of South Korea, comprises 89 small islands. These volcanic islands were created by an eruption that also led to the formation of the Ulleungdo Islands (located in the East Sea), which are approximately 87.525 km away from Dokdo. Dokdo is important for geopolitical reasons; however, because of certain barriers to investigation, such as weather and time constraints, knowledge of its insect fauna is limited compared to that of Ulleungdo. Until 2017, insect fauna on Dokdo included 10 orders, 74 families, 165 species and 23 undetermined species; subsequently, from 2018 to 2019, we discovered 23 previously unrecorded species and three undetermined species via an insect survey.
As per our recent study, the database of insect species on Dokdo has been expanded to 10 orders, 81 families, 188 species and 23 undetermined species. This database has been registered in the Global Biodiversity Information Facility (GBIF; www.GBIF.org) and is the first record for insect fauna on Dokdo.
La dyslexie : une construction pédagogique à la croisée de normes pédagogiques divergentes
Authors: Garcia Sandrine , Oller Anne-Claudine 
Published: January 2021

Cet article s’efforce de montrer à la lumière de plusieurs enquêtes que les pratiques usuelles d’apprentissage de la lecture sont à l’origine des difficultés d’une partie des élèves qui sont ensuite définies comme « pathologiques » et attribuées à leurs spécificités cognitives. Elles sont le produit d’une histoire des normes pédagogiques qui aboutissent aujourd’hui à des pratiques « hybrides ». Ces pratiques sont inspirées à la fois des connaissances récentes sur les processus cognitifs et des démarches qui elles, correspondent à un état plus ancien des savoirs. Il en résulte une faible exposition des élèves aux pratiques les plus efficaces pour maîtriser la lecture.
The impact of organizational culture on work performance: the mediating role of intrinsic motivation
Authors: Mahamadou Zoubeyda , Fall Amar , Giraud Laurent 
Published: January 2021

L’objectif de cette étude est d’identifier les dimensions de la culture organisationnelle (Implication, Cohérence, Adaptabilité, Mission) qui affectent la performance à la tâche et celle contextuelle par le biais de la motivation intrinsèque au travail. Les résultats issus d’analyses de régression sur un échantillon de 300 salariés montrent que certaines dimensions de la culture organisationnelle sont positivement associées à la motivation intrinsèque et à la performance au travail. Prenant également appui sur la démarche d’analyse des effets indirects d’Hayes (2013), l’analyse de nos données montrent que l’effet médiateur de la motivation intrinsèque entre les sous-dimensions de la culture organisationnelle et la performance au travail dépend du type de performance : performance à la tâche ou contextuelle. Cette étude dévoile ainsi les mécanismes particuliers par lesquels la culture organisationnelle influence la performance au travail par le biais de la motivation intrinsèque. Les contributions théoriques et managériales sont discutées.
La création de valeur des fintechs dans l’offre de services bancaires et financiers : entre deshumanisation et réhumanisation
Authors: Biot-Paquerot Guillaume , Assadi Djamchid , Ashta Arvind 
Published: January 2021

Notre contribution se situe sur un axe alternatif de recherche, encore peu investigué, autour de la question de la réhumanisation/déshumanisation qui résulterait de l’offre numérique de services financiers. À travers quatre études de cas originales (Chine, Vietnam, Europe et États-Unis), nous avons constaté que l’automatisation des routines par les fintech s, générant des économies d’échelle et de coûts de transaction, permettait aux opérateurs (banques, bigtech , telecom, IMF) une appropriation de ce supplément de valeur sous différentes formes. Parmi celles-ci, nos résultats suggèrent que la libération du temps consacré aux formalités bureaucratiques par les employés de ces institutions peut être réaffectée à la relation client et à la personnalisation des services proposés. Nous concluons que ce supplément de valeur peut contribuer à favoriser, de façon paradoxale, les interactions humaines (et par conséquent la réhumanisation) au sein de ces relations commerciales. Code JEL : O33, O35, G21, G30
Climat d’innovation, soutien du leader à l’innovation et rôle médiateur du bien-être au travail : quels effets sur les comportements innovants au travail ?
Authors: Dornelas Muzi Merielly , Dose Eric , Desrumaux Pascale 
Published: January 2021

Cette étude vise à examiner les liens entre les comportements innovants au travail (CIT), le climat d’innovation dans l’équipe de travail et le soutien du leader à l’innovation. En s’appuyant sur la théorie eudémonique du bien-être psychologique au travail (BEPT) basée sur l’idée de fonctionnement optimal, nous cherchons à savoir si le BEPT agit comme un médiateur spécifique d’une part entre le climat d’innovation dans l’équipe de travail (VI 1) et d’autre part le soutien au leader de l’innovation (VI 2) et les CIT (VD). 100 participants issus de deux grandes entreprises du secteur bancaire français ont complété un questionnaire. Des analyses de corrélations montrent des liens entre toutes les variables. D’après les analyses de médiations (Hayes, Preacher, 2014), le BEPT a un effet indirect entre d’une part, le climat d’innovation et d’autre part, le soutien du leader à l’innovation avec les CIT. Codes JEL : O32