bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis
Authors: Zhou Mi , Zang Jinhui , Qian Yuxuan , Zhang Qiang , Wang Yifan , Yao Tingting , Yan Hongyu , Zhang Kai , Cai Xiaojun , Jiang Lixian , Zheng Yuanyi 
Published: February 2025

AbstractThe immune‐inflammatory responses in the brain represent a key therapeutic target to ameliorate brain injury following intracerebral hemorrhage (ICH), where pro‐inflammatory microglia and its mitochondrial dysfunction plays a pivotal role. Mitochondrial transplantation is a promising strategy to improve the cellular mitochondrial function and thus modulate their immune properties. However, the transplantation of naked mitochondria into the brain has been constrained by the peripheral clearance and the difficulty in achieving selective access to the brain. Here, a novel strategy for mitochondrial transplantation via intravenous injection of magnetically responsive artificial cells (ACs) are proposed. ACs can protect the loaded mitochondria and selectively accumulate around the lesion under an external magnetic field (EMF). In this study, mitochondria released from ACs can effectively improve microglial mitochondrial function, attenuate their pro‐inflammatory attributes, and elevate the proportion of immunosuppressive microglia. In this way, microglia immune homeostasis in the brain is reestablished, and inflammation is attenuated, ultimately promoting functional recovery. This study presents an effective approach to transplant mitochondria into the brain, offering a promising alternative to modulate the immune‐inflammatory cascade in the brain following ICH.
Enabling low Threshold Laser Through an Asymmetric Tetramer Metasurface Harnessing Polarization‐Independent Quasi‐BICs
Authors: Wang Tao , Di Weizheng , Sha W. E. I. , Proietti Zaccaria Remo 
Published: February 2025

AbstractIt is proposed and numerically demonstrated a novel strategy to achieve lasing generation from a dual‐band symmetry‐protected bound states in the continuum (BICs) based on a nanodisk tetramer metasurface. The method involves breaking the in‐plane symmetry of the metasurface unit cell by the simple introduction of air holes in the tetramers. The numerical results show that this easy to fabricate solution enables the support of dual‐band BICs in the telecom‐band range, with these modes evolving into quasi‐BICs with remarkably high quality factors. Furthermore, the resulting device exhibits the unique characteristic of being polarization‐independent across all viewing angles. Finally, the adopted gain medium provides sufficient optical gain to compensate the quasi‐BIC mode losses, enabling two mode lasing with ultra‐low pump threshold and very narrow optical linewidth. This work paves the way for polarization‐independent metasurfaces with multiple lasing resonances, holding the potential to transform areas such as low‐threshold lasing and biosensing by delivering improved performance and broader capabilities.
High Throughput Screening of CMAS Corrosion‐Resistant RETaO4 Based on Lamination Method
Authors: Tian Zhilin , Chen Zhilin , Wen Shuping , Zhao Wenxia , Zheng Liya , Li Bin 
Published: February 2025

AbstractRare earth tantalates (RETaO4), known for their exceptional thermomechanical properties, are promising candidates for next‐generation thermal barrier coatings (TBCs). However, the role of rare earth (RE) species in the CMAS (calcium‐magnesium‐aluminosilicate) corrosion behavior and mechanisms of RETaO4 remains unclear, hindering their design and application as TBCs. This study employs a high‐throughput approach to systematically investigate the CMAS corrosion mechanisms of RETaO4 (RE = Nd, Sm, Eu, Gd, Dy, Ho, Y, and Er) at 1300 °C. Precise analysis of the microstructure and composition reveal that the primary corrosion products are (Ca2‐xREx)(Ta2‐y‐zMgyAlz)O7 solid solutions, along with minor amounts of Ca2RE8(SiO4)6O2 apatite. These corrosion products are observed both in the recession layer and at grain boundaries. The CMAS infiltration depth of RETaO4 increases with the RE ionic radius. First‐principles calculations indicate that the formation enthalpy of corrosion products becomes more exothermic as the RE ionic radius increases, promoting the formation of corrosion products. Additionally, the wetting behavior of liquid CMAS on RETaO4 at high temperatures supports that RETaO4 with smaller RE ionic radius present better corrosion resistance. These findings provide insights into the influence of RE species on the CMAS corrosion behavior of RETaO4, offering guidelines for the rapid screening of CMAS‐resistant TBC materials.
Treatment of Relapsed/Refractory AML—Novel Treatment Options Including Immunotherapy
Authors: Moore Catherine Gutierrez , Stein Anthony , Fathi Amir T. , Pullarkat Vinod 
Published: February 2025

ABSTRACTAcute myeloid leukemia is a molecularly heterogenous disease caused by the rapid expansion and impaired differentiation of malignant myeloid progenitors. Overall, outcomes remain poor, and more than half of patients develop relapsed or refractory disease after front‐line therapy. Allogeneic hematopoietic stem cell transplant (HCT) remains the best chance for cure for eligible patients, and the development of novel therapies including BCL2, FLT3, IDH1/2 and menin inhibitors, which are efficacious yet generally more tolerable, have enabled better bridging to prompt HCT. Despite the early success of targeted therapies, more generalized and efficacious therapeutic approaches remain in need, and numerous targeted immunotherapeutic agents (including CAR‐T, bispecific and trispecific antibody therapies) are currently under investigation.
Using 3D Photogrammetry to Quantify Usable Space in Zoo‐Housed Primate Habitats
Authors: Ritzler Charles P. , Mather Stephen V. , Johnson India T. , Dennis Patricia M. , Lukas Kristen E. , Koester Diana C. 
Published: February 2025

ABSTRACTStudies of zoo animal space use typically use ground‐level measurements as a proxy for “usable space,” but this method ignores above ground areas that are behaviorally relevant to arboreal species. Previous work has proposed different methods to calculate usable above ground space, but each has presented different limitations, ranging from the estimation of areas of dense complexity to the significant manual effort needed to physically measure spaces. To address these limitations, we tested a new, 3D photogrammetry‐based method (“3DP method”) for calculating usable space in the habitats of two zoo‐housed primate species (crowned lemur [Eulemur coronatus], and Bornean orangutan [Pongo pygmaeus]). 3D photogrammetry generates a 3D point cloud and subsequent mesh, using physically captured images, with geometric, measurable properties. Our method was compared to a previously published method, based in SketchUp, (“MSU method”) for both quantification of usable space (surface area, volume) and efficiency of model generation (active and passive work required). The 3DP method generated similar results for both usable surface area and volume for the crowned lemur habitat, while requiring 82% less active work from the user. Furthermore, the 3DP method was able to calculate usable space in a habitat (Bornean orangutan) that was 13,274% larger than the crowned lemur habitat, and substantially larger than any habitat where the MSU method has been applied in published work. Overall, the 3DP method decreased the ratio of active to passive work required for calculating usable space in zoo habitats with complex vertical space, and is flexible enough to be applied to habitats of varying sizes.
Superconducting Diode Effects: Mechanisms, Materials and Applications
Authors: Ma Jiajun , Zhan Ruiya , Lin Xiao 
Published: February 2025

AbstractSuperconducting diode effects (SDEs) generally emerge in superconducting systems where both time‐reversal and inversion symmetries are broken, showing nonreciprocal current characteristics: nondissipative in one direction and ohmic in the opposite. Since the discovery of the SDEs by Ando et~al. in the noncentrosymmetric superconductor [Nb/V/Ta]n in 2020, notable progress has been achieved on both the theoretical and experimental fronts. It is proposed that intrinsic SDEs are closely linked to various exotic superconducting states, such as the Fulde–Ferrell–Larkin–Ovchinnikov state, topological superconductivity, and chiral superconductivity. Recently, SDEs have emerged as important experimental tools for detecting symmetry breaking in exotic superconducting states. This advancement not only enhances the understanding of the fundamental nature of SDEs but also opens new possibilities for their applications in superconducting physics and related fields. This review focuses on the recent experimental progress in the observation of the SDEs and discusses their primary mechanisms from the perspective of material properties and symmetry breaking. Finally, the review summarizes the observed rectification efficiency of SDE devices and discusses future research directions in this rapidly developing field.
Etomidate Induces Mitochondrial Dysfunction in Glioma Cancer Cells by Inhibiting Mitochondrial Biogenesis Mediated by CREB/PGC‐1α
Authors: Shi Hailiang , Cao Zhongcheng , Wei Kai 
Published: February 2025

ABSTRACTGliomas are one of the most prevalent types of solid tumors in the brain. Imbalances in mitochondrial metabolism have been implicated in the pathological progression of gliomas. Etomidate, an agonist of the γ‐aminobutyric acid type A (GABAA) receptor, is widely used in clinical settings. In this study, we report a novel pharmacological function of etomidate in regulating mitochondrial metabolism in glioma cancer cells. U87 glioma tumor cells were treated with etomidate (0.5, 1.0, and 2.0 µg/mL) for 24 h. Quantitative real‐time PCR, western blot analysis, mtDNA/nDNA ratio, MitoTracker Red staining, Complex I and IV activity, intracellular ATP levels, and mitochondrial respiration were assessed. First, etomidate exposure inhibited the expression of PGC‐1α in U87 glioma tumor cells. Further investigation revealed that etomidate suppressed the expression of Nrf1 and TFAM, the two key executors of mitochondrial biogenesis. Etomidate treatment led to damage in mitochondrial biogenesis by decreasing the mtDNA/nDNA ratio, reducing the protein expression of cytochrome B, and lowering mitochondrial mass. These changes suggest impaired mitochondrial replication and function. Correspondingly, etomidate exposure induced a “loss of mitochondrial function” by diminishing the activities of Complex I and Complex IV, the mitochondrial respiratory rate (MRR), and ATP generation. These effects highlight the detrimental impact of etomidate on the energy metabolism of glioma cells. Mechanistically, etomidate inactivated the transcription factor CREB by reducing its phosphorylation at Ser133. Activation of CREB with the second messenger cAMP restored the expression of PGC‐1α, the mtDNA/nDNA ratio, Complex IV activity, summarized mitochondrial respiratory rate (MRR), and ATP production. This suggests that CREB activation may serve as a potential therapeutic strategy to counteract etomidate's inhibitory effects on mitochondrial function in glioma cells. Our results suggest that damage to mitochondrial biogenesis is a key step in the anticancer properties of etomidate in gliomas, and the decrease in PGC‐1α and its downstream molecules may be the critical mechanism behind this effect.
Marktdurchdringung von Drohnen und Herausforderungen beim Einsatz im Bauwesen
Authors: Tschickardt Thomas , Swoboda Anna , Glock Christian , Schmitt Jürgen 
Published: February 2025

AbstractDer vorliegende Beitrag beleuchtet die Marktdurchdringung von Drohnen im Bauwesen im DACH‐Raum sowie die mit dem Drohneneinsatz auf Baustellen verbundenen Herausforderungen. Der Einsatz von Drohnen zur Baufortschrittskontrolle hat in den letzten Jahren durch moderne Erfassungsmethoden wie Fotogrammetrie und LiDAR erheblich zugenommen. Diese Technologien verbessern die Datenpräzision und die Datenerfassung, bringen jedoch auch technische, rechtliche und finanzielle Fragestellungen mit sich. Eine Studie mit 423 Vermessungsfachleuten zeigt, dass Fotogrammetrie‐Drohnen häufiger genutzt werden als LiDAR‐Drohnen, die kostenintensiver und komplexer sind. Der Beitrag beleuchtet zudem rechtliche Aspekte wie Genehmigungen, geografische Beschränkungen und Datenschutz sowie die Auswirkungen von Wetterbedingungen auf die Flugfähigkeit. Ein Praxisbeispiel zur Flugplanung veranschaulicht die Auswirkungen dieser Rahmenbedingungen auf die Durchführbarkeit von Drohnenflügen. Abschließend werden die Konsequenzen auf den Drohneneinsatz bewertet.
Digitaler Zwilling Ingenieurbauwerke – aktueller Stand und zukünftige Forschung
Authors: Hindersmann Iris , Lehan Anne , Panzer Regina , Windmann Sarah , Bednorz Jennifer 
Published: February 2025

AbstractAuf dem Weg von der reaktiven Bauwerkserhaltung zum prädiktiven Lebenszyklusmanagement stellt der Digitale Zwilling ein relevantes Werkzeug für Ingenieurbauwerke dar. Der Digitale Zwilling ist eine virtuelle dynamische Repräsentation des realen Systems und seiner Wirkzusammenhänge und ist modular aufgebaut. Die Entwicklung der Module des Digitalen Zwillings von Ingenieurbauwerken ist unterschiedlich weit fortgeschritten. Im Rahmen dieses Beitrags werden die einzelnen Module wie z. B. die Zustandserfassung, das Datenmanagement oder die Visualisierung dargestellt und ihre Ziele beschrieben. Weiterhin werden erste Beispiele für Anwendungsfälle von Digitalen Zwillingen aufgezeigt.
Prevalence of Human Papillomavirus and Genotype Distribution in Chinese Men: A Systematic Review and Meta‐Analysis
Authors: Li Yifan , Zhao Fan , Wu Dan , Qin Chuanyu , Lu Yajiao , Yang Ying , Wang Hairong , Lu Chunlei , Qiu Shengyue , Jiang Wenwen , Yan Yuxiu , Geng Xianyi , Rong Hongding , Ji Na , Lv Ning , Li Yue , Li Jing 
Published: February 2025

ABSTRACTBackgroundHuman papillomavirus (HPV) vaccination represents a cost‐effective strategy for preventing HPV‐related diseases across genders. However, the HPV vaccine has not been approved for mainland Chinese males, and the comprehensive epidemiological landscape of HPV among Chinese males from mainland China is limited.MethodsThis study aimed to address this gap by examining HPV infection data in Chinese males from January 2012 to September 2024. Four English databases (Web of Science, Embase, Medline, and Cochrane Library) and four Chinese databases (CNKI, VIP, Wanfang, and SinoMed) were systematically reviewed. Random effect models assessed pooled HPV prevalence, and subgroup analyses were conducted based on population (outpatients vs. health checkups). Genotype‐specific HPV positivity was calculated.ResultsA total of 296 studies were included, encompassing 199,233 outpatients and 16,452 health checkups. HPV prevalence was 52.45% among outpatients, with the most prevalent subtypes being HPV 6 (19.06%), 11 (13.71%), and 16 (8.29%). Among health checkups, HPV prevalence was 7.89%, with the highest prevalence subtypes being HPV 16 (3.66%), 52 (1.37%), and 58 (1.19%). Among male patients diagnosed with cancer, HPV 16 (18.50%) and 18 (5.33%) were the most common subtypes, and HPV prevalence was 82.11% among the HIV‐positive MSM population.ConclusionThe high prevalence of HPV among Chinese males, particularly among outpatients and the HIV‐positive MSM population, underscores the urgent need for targeted prevention strategies. The common subtypes identified in this analysis highlight the potential benefits of introducing HPV prophylactic vaccines to Chinese males, which could significantly reduce the burden of HPV‐related diseases across the population.
Ethylene glycol partial aqueous oxidation on Co3O4 (001) surfaces: pathways to two‐ and four‐electron products in neutral and oxidative conditions
Authors: Nkou Falonne B. S. , Kenmoe Stéphane 
Published: February 2025

The catalytic oxidation of ethylene glycol (EG) on the Co3O4 (001) surface is investigated by ab initio molecular dynamics simulations in the presence of a water layer for the A‐ and B‐ terminations. In addition to the surface structure and composition, the chemical state of the aqueous environment plays a crucial role in the oxidation process. Specifically, it depends on the concentration of surface hydroxyl groups, which can act both as proton donors and acceptors. Reference surfaces, which are generated by bringing the unhydrogenated A‐ and B‐terminated surfaces in contact with a stoichiometric water layer, show some spontaneous water dissociation, which produces a number of surface hydroxyl groups. On such an A‐terminated reference surface, the EG molecule is barely reactive. This holds even in a more oxidative state. On the B‐terminated surface, EG's decomposition into ethylenedioxy species occurs already in the reference state. Under the more oxidative hydrogen‐deficient conditions obtained by removing 8 hydrogen atoms, the reaction proceeds to the formation of the two‐electron oxidation product glycolaldehyde. Removal of altogether 16 hydrogen atoms facilitates the formation of four‐electron oxidation products such as glycolic acid and glyoxal and the observation of a transient H2O2 species which subsequently evolves to form dioxygen.
Synthesis, and Structural and Spectroscopic Analysis of Iron‐Trielyl Complexes
Authors: Griffin Liam , Bauer Alexis , Crumpton Agamemnon , Ellwanger Mathias , Heilmann Andreas , Wiesner Anja , Neidig Michael , Aldridge Simon 
Published: February 2025

The reactivity of group 13 anions of the form [(NON)E]‐ (NON = 4,5‐bis(2,6‐diisopropylanilido)‐2,7‐di‐tert‐butyl‐9,9‐dimethyl‐xanthene, E = Al, Ga, In) towards Fe(CO)5 has been investigated. In the case of the aluminyl system, both reaction outcome and product structure are highly sensitive to the availability of the potassium counterion; sequestration by 18‐crown‐6 is necessary to yield a species featuring a direct, unsupported Al–Fe bond. 2.2.2‐Cryptand, by contrast, yields a species featuring bridging carbonyl ligands, while the use of no sequestering agent at all leads to isocarbonyl bridging to aluminium. Owing to their lower oxophilicity, the heavier congeners gallium and indium more straightforwardly deliver Fe–E bonded adducts (E = Ga, In). The series of trielyl iron complexes has been interrogated by structural and computational analyses, as well as by IR and Mössbauer spectroscopies, revealing a consistent shift in bond polarity and electron richness at iron as group 13 is descended. This in turn is consistent with the diminishing donor strength of the trielyl ligand with increasing atomic number.
A Meta‐Analysis of Published Brønsted Plots Supports Brønsted's “Conventional” pKa Values: 14.00 for Water and 0.00 for H+(aq)
Authors: Silverstein Todd P. , Neils Thomas 
Published: February 2025

AbstractIn the early 1900s, Brønsted used two different pairs of pKa values for water and the aqueous proton: He denoted 14.00 and 0.00 (respectively) as the “conventional” values, and 15.74 and −1.74 (respectively) as the “rational” values. Although the conventional values have been supported by both experiment and theory, the rational values have been employed in the vast majority of studies involving Brønsted plots up to the present day. Here we present a meta‐analysis of 67 Brønsted plots published from 1924 to 2010, revealing that rational pKa’ values more frequently appear as statistical outliers (a greater than 80 % rejection rate) compared to conventional values (a roughly 50 % rejection rate) based on Q‐tests. Furthermore, in 85 % of examined plots, the conventional points align more closely with best‐fit lines. An evaluation of Hupe and Pohl's Marcus plots also shows a somewhat better fit with the conventional rather than the rational pKa’ values. Finally, in the bond length versus pKa investigations published by Brydon et al., all the rational points were statistically rejected, whereas the conventional values were accepted. From our statistical analyses, we conclude that a convincing majority of experimental evidence from published Brønsted plots leads one to question the validity of Brønsted's rational pKa’ values for water and the aqueous proton (15.74 and −1.74, respectively).
Deep foundation for high rise in tricky soil conditions and surroundings in Scandinavia – Walkthrough of various high‐rise projects from initial geology to final execution and everything in between
Authors: Lajer Ronny , Klitgaard Person Tobias , Strømgaard Hansen Martin , Dambo Nielsen Tine 
Published: February 2025

AbstractThis report explores the challenges and innovative solutions associated with constructing deep foundations for high‐rise buildings in Scandinavia. The focus is on three projects: Lighthouse and Mindet 6 in Aarhus, Denmark and Karlatornet in Gothenburg, Sweden. Each project faces complex geotechnical conditions, requiring advanced engineering techniques. The report highlights the importance of early involvement in project planning, allowing for tailored solutions to geotechnical challenges. Per Aarsleff A/S employed value engineering techniques to optimize designs, ensuring both cost‐effectiveness and structural integrity. Test piles were crucial in validating foundation designs, offering real‐time data for precise calibration. The report emphasizes the important collaborative approach between engineers, clients, and other stakeholders, leading to innovative design solutions and successful project execution. The strategic use of advanced machinery, such as Aarsleff's Bauer BG55 drilling rig, underscores the technical prowess required for these projects. The report showcases how complex soil conditions and engineering hurdles were overcome through meticulous planning, technology, and continuous collaboration, setting a standard for high‐rise construction in challenging environments in Scandinavia.
Teenage Pregnancy and Its Associated Factors Among Girls Aged 13–19 Years in Apac District, Uganda: A Community‐Based Cross‐Sectional Study
Authors: Faith Ewach Gracious , Ikwara Emmanuel Asher , Marvin Musinguzi , Isiko Isaac 
Published: February 2025

ABSTRACTBackgroundThis study examined teenage pregnancy among girls aged 13–19 years in Apac District, Uganda, focusing on socioeconomic, cultural, and behavioral factors. It aimed to identify prevalence and key contributors to inform targeted interventions and improve adolescent reproductive health.MethodsThis study employed a descriptive cross‐sectional design in Apac District, Uganda. It surveyed 432 teenage girls (13–19) using structured questionnaires to examine sociodemographic, behavioral, and sociocultural factors affecting teenage pregnancy. Data analysis was conducted in Excel and SPSS.ResultsThis study identified critical factors influencing teenage pregnancy among girls aged 13–19. A striking 84.1% of pregnant adolescents are aged 13–14, demonstrating age as a primary risk factor. Educational disparities emerge, with no formal education significantly lowering pregnancy odds (AOR: 0.16, CI: 0.03–0.80). Conversely, higher parental education correlates with increased risk (AOR: 3.50, CI: 1.50–8.15). Cultural influences are notable; Muslim (AOR: 4.60, CI: 1.56–13.58) and Protestant affiliations (AOR: 2.09, CI: 1.08–4.09) elevate risks, while early marriage (AOR: 7.57, CI: 3.44–16.64) and schooling challenges (AOR: 6.97, CI: 3.18–15.31) further exacerbate vulnerability.ConclusionThis study highlights the critical factors contributing to teenage pregnancy in Apac District, Uganda, including younger age, educational disparities, and cultural affiliations. Early marriage and schooling challenges also increase vulnerability, emphasizing the need for targeted interventions to improve maternal health outcomes.