bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of tortuous vertebral arteries before cervical spine surgery: illustrative case
Authors: Sarmiento J. Manuel , Cohen Justin D. , Babadjouni Robin M. , Quintero-Consuegra Miguel D. , Gonzalez Nestor R. , Perry Tiffany G. 
Published: May 2021

BACKGROUND
Cervical spine surgery sometimes necessitates complex ventral/dorsal approaches or osteotomies that place the vertebral artery (VA) at risk of inadvertent injury. Tortuosity of the VA poses increased risk of vessel injury during anterior decompression or placement of posterior instrumentation.

OBSERVATIONS
In this report, the authors describe a patient with degenerative cervical spondylotic myelopathy and focal kyphotic deformity requiring corrective surgery via a combined ventral/dorsal approach. Computed tomography (CT) and CT angiography (CTA) of the spine identified a left medially enlarged C4 transverse foramen and tortuous VA V2 segment forming a potentially dangerous medial loop into the vertebral body, respectively. The patient’s presentation and management are described.

LESSONS
The course of the VA is variable, and a tortuous VA with significant medial or lateral displacement may be dangerous during ventral and dorsal approaches to the cervical spine. CTA of the cervical spine is warranted in cases in which atlantoaxial fixation is needed or suspicious transverse foramen morphology is identified to understand the course of the VA and identify anatomical variations that would put the VA at risk during cervical spine surgery.
Characterization of Yeast Strains with Ketoreductase Activity for Bioreduction of Ketones
Authors: Csuka Pál , Nagy-Győr László , Molnár Zsófia , Paizs Csaba , Bódai Viktória , Poppe László 
Published: May 2021

This study describes six yeast strains for stereoselective ketone reductions. The reaction conditions for the yeast strains (Pichia carsonii, Lodderomyces elongisporus, Candida norvegica, Candida guillermondi, Debaromyces fabryi and Candida parapsilosis) were optimized in a design of experiments for three ketones of different properties. The pH tolerance, temperature stability and productivity of the bioreductions with lyophilized cells of the yeast strains were characterized. In several cases, the optimized bioreductions resulted in enantiopure alcohols (ee > 99 %) with conversions ranging from moderate to excellent.
ANALISIS PRODUKTIVITAS TENAGA KERJA PADA PEKERJAAN PASANGAN BATA PERUMAHAN TIPE 36 (Studi Kasus pada Perumahan Griya Putri Tanjung Kota Bengkulu)
Authors: Yulianty Chindy , Supriani Fepy , Gunawan Agustin 
Published: May 2021

The process of housing development is inseparable from labor productivity. This study aimed to determine the value of LUR (Labor Utilization Rate), workgroup productivity, and dominant factors that influence the masonry work in Griya Putri Tanjung Housing. The method used in the research was field observations for six houses by observing the effective work time, contribution work time, and ineffective work time, calculating the area of bricklaying and questionnaires to 12 workers. The questionnaires were processed with SPSS 24. The results obtained showed that the highest worker utility factor (LUR) was on day 2 of 88.89%. The Average LUR in Putri Tanjung Griya Housing is greater than 50%, so the work utility factor reaches the effective time. The highest average productivity of each workforce is on the 3rd day by a productivity value of 1.51 m2/hour/person. The most dominant factor was the time factor and implementation conditions (up to 82%), then the physical factor of labor (32,8%), managerial (-24,1%), the background of the employee (19,1%). The lowest factor was the group factor and the expertise of the workforce by a percentage of influence of -17,5%. Keywords: housing, labor, bricklaying.
Pelatihan Pengembangan Motif dan Warna Bagi Penenun Songket Lombok di UD. Undur Pasang Sukarara
Authors: Sukarni Sri , Munawaroh Pyo Apriliana , Mahroni G L. Aswandi , Rahmat Mi’rajus Subyan 
Published: May 2021

This community service aimed to train weavers in order to have ability and skill in developing motif and color on Lombok songket. The community service is done in UD. Undur Pasang that produces and sells Lombok songket and the weavers as the participants of this community service. Preparation, implementation, monitoring and evaluation are the three methods applied in this community service. In preparation phase, through discussion between team and weavers. In the second phase, community service team prepare materials for training and trained those weavers to develop motifs by drawing and adjust the image on color of songket and followed by application in weaving activity. In monitoring and evaluation phase, community service team observed all results related to new motifs and color of songket. Through this training activity, weavers do not only have ability to draw and determine the point or line that become benchmark of formation motifs but also skill in harmonizing the motifs with yarn during weaving. The result of this training produced new motifs and color of songket without changing the characteristic motif of UD. Undur Pasang products.
A violência sexual contra a criança e as influências no seu desenvolvimento
Authors: Laguna Thalyta Freitas dos Santos , Leal Telma Garcez , Lemos Aline Priscila Subutzki , Meine Isadora Ribeiro , Rigo Henrique Carvalho , Pereira Mariana da Silva , Kruel Cristina Saling 
Published: May 2021

A violência contra a criança é caracterizada pela presença de abusos de cunho físico, sexual, emocional e psicológico, que podem afetar seu desenvolvimento. Dito isto, este artigo tem por objetivo discorrer, em específico, sobre a violência sexual contra o infante, contemplando desde aspectos relacionados aos agressores, até às consequências implicadas às vítimas, colocando em evidência, desta forma, os fatores que interferem em seu processo de maturação. Por fim, discute sobre questões relacionadas à proteção das vítimas e ao tratamento destas, a fim de evitar a piora dos traumas impressos. Trata-se de um estudo de revisão bibliográfica, para o qual foram feitas pesquisas em artigos, livros e cartilhas que abrangessem o assunto delimitado. Identificamos como resultados que em meio a tantos prejuízos, frutos de eventos estressantes e de natureza ameaçadora, vale ressaltar que a criança vítima de abuso sexual, com ou sem penetração, tem seu processo de maturação e organização cerebral ameaçados. Identificou-se a carência de novos estudos, pesquisas e bibliografias de modo geral que trabalhem o tema, além de poucos métodos de divulgação preventiva. Concluímos, ao final do estudo, que o abuso sexual contra a criança geralmente poderá inscrever na vítima diversas marcas, muitas vezes em decorrência da violência física e psicológica associadas ao evento, uma vez que o sujeito que sofre o abuso, ainda não está preparado - do ponto de vista físico, emocional e psicológico - para o ato sexual.
Integrated clinical treatment of external cervical resorption: Case report
Authors: Figueiredo Cássio Messias Beija Flor , Figueiredo Leonardo Raniel , Costa Luy de Abreu , Sonoda Paulo Koji Hara , Freire Julliana Cariry Palhano , Dias-Ribeiro Eduardo , Sonoda Celso Koogi 
Published: May 2021

External cervical resorption (ECR) has an inflammatory nature and the proximity to the gingival sulcus favors contamination and progression of the lesion. Change in crown color, inflammation of the marginal gingiva or even the presence of secretion in the gingival sulcus are the main clinical signs. Being an asymptomatic lesion, it can be neglected and its progression can jeopardize the tooth involved. This report describes the treatment of a patient who presented two teeth with ECR. On clinical examination, the crown of tooth 17 showed a pinkish translucency on the occlusal surface. On tooth 12, this spot was dark and located in the cervical third of the labial surface of the crown. Both the teeth were asymptomatic, and the radiographic examination showed an image comparable with root resorption in the cervical third of the crown. On tooth 17, the middle and cervical third of the crown was compromised and the pulp vitality test was negative. The treatment for the case was extraction. A tomographic examination of tooth 12 demonstrated pulpal involvement and biologic width violation. The vitality test was positive. After endodontic treatment, the tooth was extruded by 4 mm, the resorbed area was exposed and restored with composite resin. A 39-month clinical and radiographic control showed integrity of the root surface and the periodontium. It was found that early diagnosis influences the prognosis of treatment considering the speed of progression of resorption. It emphasizes the importance of clinical and radiographic control of the clinical conditions that predispose to ECR.
Peranan Desain Kemasan dan Branding dalam Peningkatan Citra Merek Produk Usaha Unggulan Bandung Selatan
Authors: Bob Foster  , Fitriani Reyta  , Muhamad Deni Johansyah  , Bernadetha Nadeak  , Elfrida Sormin  
Published: May 2021

Keunikan kemasan dan bahan kemasa yang berkualitas seringkali menjadikan produk tertentu dinilai memiliki citra merek yang baik di benak konsumen, sebaliknya produk yang di kemas seadanya dan bahan kemasan yang berkualitas rendah menjadikan suatu produk dinilai memiliki citra merek yang rendah. White tea merupakan salah satu produk unggulan yang diproduksi oleh usaha mikro di Bandung selatan tepatnya desa Gambung, Pangalengan. Perkebunan teh Gambung berada di Desa Cisondari, Kecamatan Pasir Jambu, Pangalengan, Kabupaten Bandung menjadi salah satu daerah dengan komoditas teh terbaik di Indonesia, bahkan sampai ke pasar mancanegara yaitu ke pasar komoditas teh di Inggris dan Amsterdam, dirintis oleh Rudolph Eduard Kerkhoven, warga Belanda pada abad 18. Kepemilikan perkebunan teh beragam di Gambung, milik pemerintah, swasta dan masyarakat lokal. Salah satu usaha yang berkembang dikarenakan permintaan tinggi adalah produk white tea.
Kemasan produk teh asal Gambung masih dirata ratakan sederhana dan berbahan dasar dus atau kertas dan branding sederhana sehingga produk mahal menjadi terkesan murah, dan menurunkan citra merek juga permintaan produk. Penelitian ini merupakan hasil pengabdian masyarakat yang dilakukan oleh akademisi Universitas Informatika dan Bisnis Indonesia bekerja sama dengan Universitas Padjajaran Bandung, tujuan penelitian adalah untuk mengetahui faktor kemasan dan branding sebagai pendorong penningkatan citra yang dibentuk oleh kemasan dan branding tersebut, 100 responden diambil secara acak dari bagian populasi konsumen loyal di café di kota Bandung. Hasil pengolahan kuisioner menggunakan partial least square menyatakan ada pengaruh desain dan bahan kemasan juga branding terhadap citra merek produk teh putih yang diproduksi oleh usaha Menengah asal Gambung, Kab Bandung, Jabar.
Impact of Silica Nanoparticles on the Durability of fly Ash Concrete
Authors: Ali D. , Sharma U. , Singh R. , Singh L. P. 
Published: May 2021

In the present study, the mechanical and durability properties of silica nanoparticle (SNP)-incorporated fly ash (FA) concrete mix were examined after 365 days of exposure. The dosages of FA replaced by cement in the present study were 30%, 40%, and 50%, while 3% SNPs were added by the weight of cement in the FA incorporated mix. For a comparison of SNPs with silica fume (SF), 6% SF was added (by the weight of cement) and entire casting was performed at a constant water to binder (w/b) ratio of 0.29. The present work is the extension of a previous study wherein durability properties of the same mixes were reported for up to 180 days of exposure. Compressive strength results show that in the presence of SNPs, the enhancement in compressive strength was in the range of 10–14%, while, in presence of SF, 8–10% of the enhancement was observed as compared to control. However, exposed samples in a carbonation environment showed that the compressive strength of the control and SF incorporated mix increased, while SNP-incorporated samples showed negligible enhancement. Further, sulphate exposed mix show that compressive strength decreases, however, the SNP-incorporated mix showed the lowest reduction compared to other mixes. Therefore, the study shows that the SNP-incorporated mix has higher mechanical properties and more durability compared to other mixes in a severe environment.
Steroid Hormone Biosynthesis Metabolism Is Associated With Fatigue Related to Androgen Deprivation Therapy for Prostate Cancer
Authors: Feng Li Rebekah , Barb Jennifer J. , Allen Hannah , Regan Jeniece , Saligan Leorey 
Published: May 2021

BackgroundAndrogen deprivation therapy (ADT) is a cornerstone treatment for prostate cancer. Despite the clinical benefits, ADT is associated with multiple adverse effects including fatigue. The goal of the study was to examine metabolomic changes to better understand cancer-related fatigue specific to ADT treatment.MethodsA total of 160 plasma samples collected from participants with (+ADT,n= 58) or without neoadjuvant ADT (−ADT,n= 102) prior to radiation therapy for treatment of non-metastatic localized prostate cancer were included in the study. Fatigue and sleep-related impairment were measured using the Patient Reported Outcomes Measurement Information System. Plasma metabolites were identified and measured using untargeted ultrahigh-performance liquid chromatography/mass spectrometry metabolomics analyses. Partial least square discriminant analysis was used to identify discriminant metabolite features, and the diagnostic performance of selected classifiers was quantified using AUROC curve analysis. Pathway enrichment analysis was performed using metabolite sets enrichment analyses.FindingsSteroid hormone biosynthesis pathways, including androstenedione metabolism as well as androgen and estrogen metabolism, were overrepresented by metabolites that significantly discriminated samples in the +ADT from the −ADT group. Additional overrepresented metabolic pathways included amino acid metabolism, glutathione metabolism, and carnitine synthesis. Of the metabolites that were significantly different between the groups, steroid hormone biosynthesis metabolites were most significantly correlated with fatigue severity. Sleep-related impairment was strongly correlated with fatigue severity and inversely correlated with ADT-induced reduction in androsterone sulfate.ConclusionsPatients with non-metastatic prostate cancer receiving neoadjuvant ADT prior to radiation therapy reported relatively more severe fatigue. Increased fatigue in this population may be attributable to sleep-related impairment associated with alterations in steroid hormone biosynthesis. Findings in this study provide a basis for further research of changes in sleep patterns and their role in this specific subcategory of cancer-related fatigue caused by the treatment.
Fabrication of the Ni-NiCl2 Composite Cathode Material for Fast-Response Thermal Batteries
Authors: Tian Qianqiu , Wang Jiajun , Xiang Wendi , Zhao Jun , Guo Hao , Hu Jing , Han Xiaopeng , Hu Wenbin 
Published: May 2021

Thermal batteries with a high power density and rapid activation time are crucial for improving the fast response ability of sophisticated weapons. In this study, an Ni-NiCl2 composite was prepared via hydrogen reduction and employed as a cathode material. Discharge tests on a battery assembled using the fabricated composite revealed that its initial internal resistance decreased and the activation time reduced. Notably, the Ni-NiCl2 cathode increased the energy output by 47% (from 6.76 to 9.94 Wh in NiCl2 and Ni-NiCl2, respectively) with a cut-off voltage of 25 V; the power density of the novel battery system reached 11.4 kW/kg. The excellent performance of the thermal battery benefited from the high electrode potential and low internal resistance of Ni-NiCl2. This study contributes to the development of high-performance electrode materials for next-generation thermal battery-related technologies.
Long-Term Effect of Salt Substitute on All-Cause and Cardiovascular Disease Mortality: An Exploratory Follow-Up of a Randomized Controlled Trial
Authors: Sun Hao , Ma Bing , Wu Xiaomei , Wang Hailong , Zhou Bo 
Published: May 2021

Background: Salt substitute, a strategy for salt reduction, has been shown to decrease blood pressure and the incidence of hypertension. However, whether its hypotensive effect will reduce long-term mortality remains unclear. Our study reported an exploratory follow-up of mortality outcomes from previous randomized controlled trial to assess the long-term effect of low-sodium salt on total and cardiovascular disease (CVD) mortality.Methods: Participants who completed a previous 3-year double-blind randomized controlled trial were followed up from 2009 to 2019 to collect mortality data. Multivariable Cox regression models were used to evaluate the association between low-sodium salt intervention and all-cause and CVD mortality.Results: Four hundred and forty participants completed the intervention trial, of which 428 participants had death outcome data recorded after 10 years follow-up: 209 in a salt substitute group and 219 in a normal salt group. Fifty participants died during follow-up, 25 died due to CVD. No significant differences in relative risks were found for all-cause mortality [HR = 0.81, 95% confidence interval (CI): 0.46–1.42] and CVD mortality (HR = 0.58, 95% CI: 0.26–1.32) in unadjusted analyses. After adjusted with age and alcohol drinking status, there were significant reductions for stroke mortality among all participants (HR = 0.26, 95% CI: 0.08–0.84) and for CVD mortality (HR = 0.38, 95% CI: 0.16–0.92) and stroke mortality (HR = 0.25, 95% CI: 0.08–0.82) among hypertensive participants.Conclusions: Compared to normal salt, salt substitute might reduce the risk of CVD death, especially stroke among hypertensive patients. Our exploratory follow-up results provide potential evidence that low-sodium salt may be an accessible and effective strategy for prevention of CVD events, but definitive randomized controlled trials are warranted.
Veno-Arterial Extracorporeal Membrane Oxygenation for Patients Undergoing Acute Type A Aortic Dissection Surgery: A Six-Year Experience
Authors: Hou Jun-yi , Wang Chun-sheng , Lai Hao , Sun Yong-xin , Li Xin , Zheng Ji-li , Wang Huan , Luo Jing-chao , Tu Guo-wei , Luo Zhe 
Published: May 2021

Objectives: Acute type A aortic dissection (aTAAD) is usually lethal without emergency surgery. Although veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in patients with cardiogenic shock following cardiac surgery, VA-ECMO support following aTAAD surgery has not been well-described. Based on our 6-year experience, we aimed to retrospectively analyze risk factors, application and timing of VA-ECMO, and outcomes in aTAAD patients.Methods: In this retrospective, single-center study, we enrolled adult patients who underwent aTAAD surgery from January 2014 to December 2019 and were supported with VA-ECMO. Patients were divided into two groups according to whether or not they were successfully weaned from VA-ECMO. Preoperative, intraoperative and postoperative variables were assessed and analyzed. Outcomes of the patients were followed up until discharge.Results: Twenty-seven patients who received aTAAD surgery with VA-ECMO support were included in the study. Nine patients (33.3%) were successfully weaned from VA-ECMO. The median VA-ECMO support time and length of hospital stay in the successfully weaned group were significantly longer than in the group could not be successfully weaned (192 [111–327] vs. 55 [23–95] h, p &lt; 0.01; 29 [18–40] vs. 4 [3–8] days, p &lt; 0.01). Overall in-hospital mortality was 81.5%. The main causes of death were bleeding (37%), neurological complications (15%), and multiple organ dysfunction syndrome (15%). Preoperative levels of creatine kinase-MB (CK-MB) were lower in patients who were successfully weaned from VA-ECMO than in the failed group (14 [6–30] vs. 55 [28–138] U/L, p &lt; 0.01). Postoperative peak levels of CK-MB, cardiac troponin T, lactate dehydrogenase, and lactate were significantly lower in the successful group than in the failed group.Conclusion: Postoperative VA-ECMO support was rarely used in aTAAD patients. Our study showed that VA-ECMO can be considered as a salvage treatment in aTAAD patients, despite the high rate of complications and mortality.
Microbial Communities of the Drinking Water With Gradient Radon Concentration Are Primarily Contributed by Radon and Heavy Metal Content
Authors: Nayak Tilak , De Debjit , Karmakar Parimal , Deb Argha , Dhal Paltu Kumar 
Published: May 2021

Radon and heavy metal (HM) contamination in drinking water and their impact on health have been reported earlier. However, relatively little is known about the microbial community in drinking water with gradients of radon and the drivers of microbial community patterns in such water. With this view, we first examine microbial dynamics of drinking water in the permissible level of 93 ± 2 Bq/l as control, 510 ± 1.5 6 Bq/l and 576 ± 2 Bq/l as medium, and 728 ± 3 Bq/l as high radon-containing tube wells from Dumka and Godda districts, which comes under a major fault of the eastern fringes of India. Attempts have also been made to predict the impact of the radon contamination gradient and other water environmental parameters on community structure. The measured physicochemical character revealed strong clustering by the sampling site with respect to its radon and HM content. The radon-contaminated sites represent HM-rich nutrient-limited sites compared to the control. Radon (Rn), HM (Pb, Cu, and As), and total suspended solids (TSSs) were the most determinant variable among the parameters and influenced the microbial community composition of that region. The microbial diversity of those sites was lower, and this measured diversity decreased gradually on the sites with an increased gradient of radon contamination. The dominant microbial families in the contaminated sites were Moraxellaceae, Chitinophagaceae, unclassified Candidatus Azambacteria, unclassified Candidatus Moranbacteria, unclassified Candidatus Collierbacteria, and Gammaproteobacterial members, which are reported to abundantly inhabit radiation and chemolithotrophic environments and pose better radionuclide protective mechanisms, while the bacterial members dominant in the control site were Comamonadaceae, Rhodocyclaceae, Nitrospirales Incertae Sedis, cvE6, unclassified Woesearchaeota (DHVEG-6), and Holophagaceae, which are reported to be abundant in natural soil and drinking water, and labile in harsh environments. Relative sequence abundance of Comamonadaceae was decreasing on the sites with an increasing radon gradient, while the opposite trend was observed for Chitinophagaceae. The distribution of such microbial assemblages is linked to radon and heavy metal, highlighting that taxa with distinct environmental preferences underlie apparent clustering by sites; thus, we can utilize them for biostimulation-based in situ bioremediation purposes.