bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Can you hear me?’ An exploratory study investigating the representation and impact of children’s views in multi‐agency meetings
Authors: Mitchell Kerry L. , Colville Tracey 
Published: October 2021

AbstractThe study explored parent and professional perceptions of the representation of children's views in multi‐agency meetings in Scottish schools. Online survey (134 responses) and educational documents provided data sources that were subject to thematic and documentary analysis. The findings highlight the importance of professional beliefs around child capacity and their understanding of what constitutes a competent view. In turn, they influence the extent to which professionals find representations of children's views worthwhile. Implications for practice include raising professional awareness of evolving ontologies around the representation of children's views in multi‐agency meetings in line with policy and legislation.
Telemedicine based remote monitoring after liver transplantation: Feasible in a select group and a more stringent control of immunosuppression
Authors: Koc Özgür Muhammet , Pierco Marleen , Remans Kathleen , Van den Hende Thijs , Verbeek Jef , Van Malenstein Hannah , Van der Merwe Schalk , Robaeys Geert , Monbaliu Diethard , Pirenne Jacques , Van den Bosch Bart , Dobbels Fabienne , Nevens Frederik 
Published: October 2021

AbstractTelemedicine gained interest in liver transplant patients but focused until now on the early post‐operative period. This prospective cohort study assessed feasibility, safety, and clinical beneficial effects of a telemedicine based remote monitoring program (TRMP) for the chronic follow‐up of adult liver transplant recipients. Between November 2017 and August 2019, a total of 87 of the 115 selected patients (76%) started the TRMP. Over the 2 years study period, none of the patients switched to standard follow‐up: 39/87 (45%) continued to do this autonomously and 48/87 (55%) stopped to report their data personally but communicated their lab values to the nurse. The other 28/115 (11%) patients who did not accept the TRMP continued the standard follow‐up. There was no difference in educational level between the three groups. Remote monitoring did not result in an increase in liver graft rejection and need of hospitalization. TRMP was associated with a higher number of tacrolimus level determinations and tacrolimus blood level concentrations could be kept lower. In conclusion, our results show that in patients with a stable clinical condition there is a high willingness to participate in TRMP and that this approach is safe. Remote monitoring allowed a stringent follow‐up of tacrolimus levels.
Effects of different scenarios of temperature rise and biological control agents on interactions between two noxious invasive plants
Authors: Zhang Xiaoliang , Yu Haihao , Lv Tian , Yang Lei , Liu Chunhua , Fan Shufeng , Yu Dan 
Published: October 2021

AbstractAimAn increasing number of exotic plants and their biological control agents are being introduced into new regions. Therefore, it is necessary to study their interactions and to manage the future directions of plant invasions under different scenarios of temperature rise.LocationChina.MethodWe investigated the distribution patterns of the two most prevalent invasive aquatic plants in the world, Alternanthera philoxeroides and Eichhornia crassipes, at a large scale and studied the interactions of both invasive plants with their respective biological control agents, Agasicles hygrophila and Neochetina eichhorniae, in response to different scenarios of temperature rise.ResultsBoth plants performed better in warmer climates in common garden experiments. However, large populations of A. philoxeroides occurred only in the temperate zone because this species experienced competitive exclusion from E. crassipes and suppression due to A. hygrophila herbivory in tropical and subtropical areas. Moreover, in both subtropical zones, where the two plants and A. hygrophila co‐occur, and the temperate zone, where only A. philoxeroides occurs at present, A. hygrophila herbivory and the competition from E. crassipes hindered the performance of A. philoxeroides. Moreover, in the extreme high‐temperature environment, A. philoxeroides performance improved, while E. crassipes performance worsened. In addition, the combination of N. eichhorniae herbivory and competition from A. philoxeroides also reduced the performance of E. crassipes, but E. crassipes still dominated when in competition with A. philoxeroides.Main conclusionsOur results indicate that climate warming and the introduction of herbivores do not alter the interspecific relationship between E. crassipes and A. philoxeroides. Moreover, our study suggests that under climate warming, E. crassipes will replace A. philoxeroides as the dominant species in some communities in warm temperate zones, though extremely high‐temperature events will slow this replacement process.
Comparing survival outcomes for kidney transplant recipients with pre‐existing diabetes versus those who develop post‐transplantation diabetes
Authors: Hussain Azm , Culliford Alice , Phagura Nuvreen , Evison Felicity , Gallier Suzy , Sharif Adnan 
Published: October 2021

AbstractIntroductionThe aim of this study was to compare the management strategy and clinical outcomes for kidney transplant recipients with pre‐transplant versus post‐transplantation diabetes (PTDM) in a contemporary cohort.MethodsThis is a single‐centre, retrospective. observational study of kidney transplant recipients between 2007 and 2018 with follow‐up to 31 December 2020. Data were extracted from hospital electronic patient records, with clinical outcomes linked to national data sets. PTDM was diagnosed by international consensus guidelines. Unadjusted and adjusted survival outcomes were assessed with Kaplan–Meier curves and Cox regression models, respectively, with PTDM handled as a time‐varying covariate.ResultsData were analysed for 1,757 kidney transplant recipients, of whom 11.8% (n = 207) had pre‐transplant diabetes, and 13.8% (n = 243) developed PTDM with median time to onset 108 days (IQR 46–549 days). Median follow‐up was 1,839 days (IQR 928–2985 days). Disparate management strategies were observed, although insulin was the commonest glucose‐lowering therapy for all patients with diabetes. In adjusted models, PTDM was associated with lower mortality (HR 0.663, 95% CI 0.543–0.810) and pre‐diabetes with higher mortality (HR 1.675, 95% CI 1.396–2.011). However, if analyses are restricted to those with at least 5‐year follow‐up, then PTDM has no association with mortality (HR 0.771, 95% CI 0.419–1.096), but pre‐transplant diabetes remains associated with higher mortality (HR 2.029, 95% CI 1.367–3.012).ConclusionsPre‐transplant diabetes remains associated with increased mortality risk after kidney transplantation, but PTDM effects are time dependent. Development of PTDM should be encouraged as a mandated registry return to study the long‐term impact on survival outcomes.
The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension
Authors: Rezaeian Nahid , Asadian Sanaz , Parsaee Mozhgan , Toloueitabar Yaser , Hemmati Komasi Mohammad Mehdi , Shayan Leila , Hosseini Leila 
Published: October 2021

AbstractObjectivesWe sought to determine the cardiac magnetic resonance (CMR) indicators of intermediately to highly probable pulmonary hypertension (IHpPH) in patients with thalassemia referred for myocardial iron overload assessments to prevent further cardiac complications.MethodsThe study population consisted of 152 patients with thalassemia (major or intermedia) (49.3% women, mean age = 33 ± 10.1 years) who underwent non‐contrast CMR and echocardiographic examinations on the same day. Functional, T2*, and global strain parameters via a feature‐tracking method were extracted from CMR. The probability of PH was defined based on the tricuspid regurgitation velocity and echocardiographic parameters. The catheterization‐derived hemodynamic data of patients with moderate to high probable PH was registered.ResultsTwenty‐two (14.5%) patients suffered from IHpPH. The multivariate logistic regression analysis revealed that the right ventricular end‐systolic volume index (RVESVI) was the strongest of all the CMR parameters for the prediction of IHpPH (OR: 1.044, 95% CI: 1.021–1.067). The other powerful IHpPH predictor was age (OR: 1.066, 95% CI: 1.009–1.126). A cutoff point of greater than 47 ml for RVESVI (AUC: .801, 95% CI: .728–.861) was found to predict IHpPH with 73.91% sensitivity and 70.31% specificity. The single most robust CMR‐derived strain parameter for IHpPH prediction was the right ventricular global longitudinal strain (OR: .887, 95% CI: .818–.961). A p value of less than 0.05 was considered significant.ConclusionsBoth CMR functional and global strain parameters were strong predictors of IHpPH in our patients with thalassemia.
Fatigue life prediction of structural steel using acoustic birefringence and characteristics of persistent slip bands
Authors: Gonchar Alexander Victorovich , Kurashkin Konstantin Vladimirovich , Andreeva Olga Vyacheslavovna , Anosov Maxim Sergeevich , Klyushnikov Vyacheslav Alexandrovich 
Published: October 2021

AbstractNondestructive evaluation methods provide additional information about the material fatigue behavior and enhance the comprehension of damage evolution thanks to relationship between microstructure and physical properties. This paper deals with optical and ultrasonic investigations of structural steel specimens tested for low‐cycle fatigue. The development of persistent slip bands observed on the surface with an optical microscope was quantified using a previously trained neural network and fractal analysis. A surface damage parameter was defined as the ratio of total area of detected slip bands to the area of observed surface. Relationships between the rate of change and critical value of the damage parameter, the strain range, and the fatigue life were established. A single square relationship between relative number of cycles and ratio of the surface damage parameter to its critical value was obtained. Acoustic birefringence was measured by the echo method. The effect of the strain range on the rate of change in acoustic birefringence was investigated. A single linear relationship between relative number of cycles and change in acoustic birefringence was established. An algorithm for predicting the material remaining life, combining optical and ultrasonic data, was proposed.
Patient‐reported symptoms and experience following Guillain‐Barré syndrome and related conditions: Questionnaire development and validation
Authors: Siriwardena Aloysius Niroshan , Akanuwe Joseph N. A. , Botan Vanessa , Laparidou Despina , Curtis Ffion , Jackson Jennifer , Asghar Zahid B. , Hodgson Timothy L. 
Published: October 2021

AbstractBackgroundGuillain‐Barré syndrome (GBS) is a rare inflammatory peripheral nerve disorder with variable recovery. Evidence is lacking on experiences of people with GBS and measurement of these experiences.ObjectiveWe aimed to develop and validate an instrument to measure experiences of people with GBS.DesignWe used a cross‐sectional design and online self‐administered questionnaire survey. Question domains, based on a previous systematic review and qualitative study, covered experiences of GBS, symptom severity at each stage, healthcare and factors supporting or hindering recovery. Descriptive, exploratory factor and reliability analyses and multivariable regression analysis were used to investigate the relationships between variables of interest, explore questionnaire reliability and validity and identify factors predicting recovery.Setting and ParticipantsPeople with a previous diagnosis of GBS were recruited through a social media advert.ResultsA total of 291 responders, of different sexes, and marital statuses, were included, with most diagnosed between 2015 and 2019. Factor analysis showed four scales: symptoms, information provided, factors affecting recovery and care received. Positive social interactions, physical activity including physiotherapy and movement, changes made at home and immunoglobulin treatment were important for recovery. Multivariable models showed that immunoglobulin and/or plasma exchange were significant predictors of recovery. Employment and recovery factors (positive interactions, work support and changes at work or home, physical activity and therapy), though associated with recovery, did not reach statistical significance.ConclusionThe questionnaire demonstrated good internal reliability of scales and subscales and construct validity for people following GBS.Patient ContributionPatients were involved in developing and piloting the questionnaire.
Antiradical and functional properties of subcritical water extracts from edible mushrooms and from commercial counterparts
Authors: Rodríguez‐Seoane Paula , Torres Perez María Dolores , Fernández de Ana Catalina , Sinde‐Stompel Esteban , Domínguez Herminia 
Published: October 2021

SummaryThis study deals with the antioxidant and functional potential of subcritical water extracts from edible mushrooms, in comparison to commercial products. Pleurotus citrinopileatus extracts showed the highest phenolic content and antioxidant properties. Similar results were determined in commercial extracts of Coriolus versicolor. The highest growth inhibition in selected human carcinogenic cells was identified for the P. citrinopileatus extract obtained during heating up to 160 °C. Rheological studies confirmed that glucan‐based hydrogels prepared with mushroom extracts exhibited enhanced viscoelastic properties compared to those formulated with commercial products. The extracts providing the strongest gels were obtained from Pleurotus eryngii, followed by Hericium erinaceus and Pleurotus citrinopileatus. No water syneresis for the proposed hydrogels was observed. The formulated hydrogels could be interesting for their application in the food sector.
Nomogram predicting testicular torsion in Japanese patients with acute scrotal pain using physical examination findings and environmental conditions: Development and prospective external validation
Authors: Takeshita Hideki , Tachibana Kojiro , Sugiyama Hironori , Kagawa Makoto , Yano Akihiro , Okada Yohei , Morozumi Makoto , Kawakami Satoru 
Published: October 2021

ObjectivesTo develop a prediction tool based on physical findings and environmental conditions without utilizing color Doppler ultrasonography to guide non‐urologists and patients’ families in determining the testicular torsion possibility among patients with acute scrotal pain.MethodsOverall, 110 consecutive patients aged ≤30 years with acute scrotal pain at Saitama Medical Center between 2012 and 2014 were retrospectively evaluated. Physical examination results, including scrotal inspection, palpation and gait observation, and environmental conditions at pain onset (time range and ambient temperature) were collected. Multivariate analysis identified significant and independent risk factors for testicular torsion, and a nomogram predicting testicular torsion was constructed. The model underwent prospective validation in an independent set of 123 consecutive patients admitted with acute scrotal pain to our institution between 2015 and 2017.ResultsTesticular torsion diagnosis rates were 27% (30/110) and 26% (32/123) in the training and validation cohorts, respectively. Logistic regression analysis showed four risk factors for developing testicular torsion: abnormal testicular position, walking difficulty, midnight to early morning onset and ambient temperature <15°C at pain onset. The constructed nomogram showed that the areas under the receiver operating characteristic curves were 0.92 and 0.84 for the training and validation cohorts, respectively. The calibration plot showed an acceptable fitness between the predicted probability and the observed rate of testicular torsion.ConclusionsA novel nomogram was developed solely based on physical findings and environmental conditions to predict testicular torsion in Japanese patients with acute scrotal pain.
Patterns and determinants of lichen abundance and diversity across a subarctic to arctic latitudinal gradient
Authors: Chagnon Catherine , Simard Martin , Boudreau Stéphane 
Published: October 2021

AbstractAimLichens are a major component of Arctic biodiversity. However, they appear vulnerable to climate change, as they are exposed to warmer temperatures and increased competition with vascular plants. Our study aims to evaluate lichen cover, species richness, functional diversity and community composition among the dominant vegetation types along a 640‐km latitudinal gradient, and to identify environmental determinants related to patterns in lichen communities.LocationFrom subarctic (56°N) to arctic (62°N) Nunavik (Québec, Canada).TaxonLichens.MethodsWe characterized macrolichen communities at the species level in 42 sites across a latitudinal gradient, and identified latitudinal trends in lichen cover, species richness and functional diversity. Using linear models and distance‐based redundancy analysis, we investigated the effect of climate, vegetation, topography and soil characteristics on lichen communities.ResultsLichen cover and species richness were the lowest at high latitudes, while functional diversity increased with increasing latitude. Vegetation types and surficial deposits were strongly related to lichen cover and richness. However, these factors did not influence functional diversity, which was mainly driven by climatic conditions.Main conclusionOur results highlight the importance of vegetation structure in lichen communities and corroborate the negative relationship between vascular plant abundance and lichen abundance and species richness. While we found no influence of vegetation structure on lichen functional diversity, further studies using targeted functional traits are needed to accurately investigate the impact of ongoing changes in northern vegetation on ecosystem functioning.
Mutational profiling of low‐grade gliomas identifies prognosis and immunotherapy‐related biomarkers and tumour immune microenvironment characteristics
Authors: Lin Wen‐wen , Ou Guan‐yong , Zhao Wei‐jiang 
Published: October 2021

AbstractLow‐grade glioma (LGG) is a heterogeneous tumour with the median survival rate less than 10 years. Therefore, it is urgent to develop efficient immunotherapy strategies of LGG. In this study, we analysed mutation profiles based on the data of 510 LGG patients from the Cancer Genome Atlas (TCGA) database and investigated the prognostic value of mutated genes and evaluate their immune infiltration. Tumor Immune Dysfunction and Exclusion (TIDE) algorithm was used to indicate the characteristics of gliomas that respond to immune checkpoint blockade (ICB) therapy. Univariate and multivariate cox regression analysis was performed to identify indicators to construct the nomogram model. 485 (95.47%) of 508 LGG samples showed gene mutation, and 9 mutated genes were significantly related to overall survival (OS), among which 6 mutated genes were significantly correlated with OS between mutation and wildtypes. Immune infiltration and immune score analyses revealed that these six mutated genes were significantly associated with tumour immune microenvironment in LGG. The response of LGG with different characteristics to ICB was evaluated by TIDE algorithm. Finally, CIC gene was screened through both univariate and multivariate Cox regression analyses, and the nomogram model was established to determine the potential prognostic value of CIC in LGG. Our study provides comprehensive analysis of mutated genes in LGG, supporting modulation of mutated genes in the management of LGG.
Yes‐associated protein is essential for proliferative vitreoretinopathy development via the epithelial‐mesenchymal transition in retinal pigment epithelial fibrosis
Authors: Zhang Wei , Li Jing 
Published: October 2021

AbstractThis study was aim to investigate whether the progression of proliferative vitreoretinopathy (PVR) depended on the activation of Yes‐associated protein (YAP) and the subsequent epithelial‐mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cell. The effect of YAP activation on retinal fibrosis in a PVR mouse model and in human ARPE‐19 cells in vitro was studied. After treated with transforming growth factor‐β2(TGF‐β2), the expressions of fibrogenic molecules, YAP activation and the TGF‐β2‐Smad signalling pathway in ARPE‐19 cells were detected by Western blot and immunocytochemical analyses. The effect of YAP on change in fibrosis and EMT was tested by knockdown experiment using verteporfin (YAP inhibitor). YAP was upregulated in the PVR mouse model and during TGF‐β2–induced RPE cell EMT. In an in vivo study, verteporfin attenuated PVR progression in a mouse model. Additionally, YAP knockdown retained phenotype of RPE cells and ameliorated TGF‐β2–induced migration, gel contraction and EMT in vitro. YAP knockdown inhibited the TGF‐β2–induced upregulation of connective tissue growth factor (CTGF), smooth muscle actin (SMA‐α) and fibronectin. YAP was essential for the TGF‐β2–induced nuclear translocation and phosphorylation of Smad2/3. Our work provides direct evidence that YAP is an essential regulator of EMT and profibrotic responses in PVR and indicates that YAP inhibition could be a potential target in PVR therapeutic intervention.
Periodontal disease and a poor response to periodontal treatment were associated with an increased risk of incident diabetes: A longitudinal cohort study in Sweden
Authors: Holmlund Anders , Lind Lars 
Published: October 2021

AbstractAimTo investigate whether periodontal disease or the response to periodontal treatment could influence the risk of future diabetes.Materials and methodsThe eligible population consisted of 8983 individuals referred for periodontal treatment between 1980 and 2015. Diabetes incidence was obtained from the Swedish registers for cause of death, hospital discharge, and national diabetes registers.Data concerning treatment outcome 1 year after treatment were available for 5258 individuals. Poor response to treatment was defined as having >10% sites with probing pocket depth ≥5 mm and bleeding on probing (BOP) at ≥20% of the sites.ResultsAmong the 8983 individuals during a median follow‐up of 21.3 years, 1117 cases of diabetes occurred. The number of teeth and BOP at baseline were significantly associated with incident diabetes in a dose‐dependent manner after adjusting for age, sex, smoking, education level, and civil status [incident rate ratio (IRR) = 0.88 (95% confidence interval [CI] 0.84–0.93), p < .001 and IRR = 1.06 (95% CI 1.02–1.11), p = .003, respectively].Poor response to treatment (14%) was associated with an increased risk (37%) for future diabetes (95% CI 1.12–1.68, p = .002) compared with good responders.ConclusionsPeriodontal disease with increased tooth loss and BOP, as well as poor response to treatment, was associated with an increased risk for diabetes.