bluuebunny/crossref_metadata_2025_split huggingface dataset:
First experience with a ready-to-use solution for remote monitoring of patients suffering from heart failure
Authors: Lemieux H , Picard F , Barritault F , Labarre J , Lafitte S , Maribas P , Chaouky H , Abdennadher M , Lasserre R , Amara W , Pages N , Nisse-Durgeat S , Diebold B 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Heart failure (HF) is associated with a high mortality rate and recurrent hospitalizations.

Purpose
To present the first data of the patients using Satelia® Cardio solution

Method
Satelia® Cardio is a HF patient management solution with a remote monitoring system and a therapeutic guidance by a dedicated-nurse phone platform, supported by the ETAPES Program. The system is accessible from any device and requiring no installation. After the inclusion, the patient is contacted by the nurse, he then receives an SMS alerts following cardiologist prescription (on regular basis), with a link leading to a web page on which he will answer 7 questions and enter his current body weight. Satelia® Cardio algorithm is based on these data inputs, their variability, and the weight. In case of worsening of symptoms, the cardiologist will be notified. Since Covid-19 lockdown, more than 1400 patients have been monitored with the solution.

Results
165 centers (306 cardiologists) are using Satelia® Cardio with 3540 HF patients monitored in the last 29 months. The patients with a mean age of 72 years (19-100) are predominantly males (67%), and mostly NYHA II/III (69%/31%) with a mean LVEF of 40%. The adherence to the system is very good (91%) with 78% of patients still monitored (n = 2787). The main reasons for stopping are related to the occurrence of death (205/753) or patient/HCP decision (392/753), or other reasons (156/753). Over the period of analysis, the HF patients answered to 163 700 questionnaires, generating 8210 alerts transmitted to the referent cardiologists.

Conclusion
Patient management solution with a remote monitoring system is key to improving the follow-up of HF patients. The solution Satelia® Cardio is an easy way to use a web application to monitor HF patients, especially on the current period of Covid-19 with a low rate of premature discontinuation. A further step will be to initiate studies to assess the potential benefits for both patients and HCPs of such remote monitoring solution in HF.
Left ventricular mass index as a predictor of coronary calcification, coronary lesion and association with coronary artery tortuosity
Authors: Farhan HASAN , Khaleel Z , Dakhil ZA 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Despite Coronary artery tortuosity (CAT) is a common angiographic finding, there is limited data regarding pathogenesis and aetiology of this coronary entity, one proposed hypothesis was the change in geometry of left ventricle (LV) which predispose for CAT. Very little is known about echocardiographic parameters and their significance in CAT.

Purpose
This study aimed to determine left ventricular mass index (LVMI) as a predictor of coronary calcium burden (represented by CT coronary calcium scoring CaCs), coronary obstructive lesions and association of LVMI with CAT in patients with chronic chest pain who were referred for coronary angiography (CA).

Methods
Cross-sectional study enrolled patients with chronic chest pain whom referred for CCTA and coronary angiography (CA). Demographic characteristics and CA results were collected. LVMI was calculated for each patient. Patients were grouped into those with CAT vs without CAT.

Results
The study recruited 150 patients including 106 (70.7%) with CAT. Among total study patients; mean LVMI was higher in elderly≥ 65 years (147.5 ± 52 vs 52.5 ± 8.4, p &lt; 0.001), hypertensive (129 ± 52.4 vs 96.6 ± 38.9, p = 0.001) and diabetics (144.2 ± 65.3 vs 102.5 ± 30.7, p = 0.001). LVMI was lower in patients with CAT (115.4 ± 46.2 vs 123.6 ± 59.8 in non-CAT group, p = 0.001), in same line, among CAT group: 49% had normal LVMI vs 45.5% in non-CAT counterparts, mild increase in LVMI seen in 18.3% vs 6.6% in non-CAT group while severe increase in LVMI seen in 33.25% vs 16.5% in non-CAT patients. Mean LVMI was higher in patients with obstructive coronary artery lesions (137.9 ± 56.3 vs 93.6 ± 27.3, p = 0.001), similarly, mean LVMI was increasing with higher grade of CT coronary calcium scoring as it was 88.5 ± 27.3 in absent CaCs while mean LVMI was 154.4 ± 62.4 in severe CaCs, p = 0.001).

Conclusion
left ventricular mass index increased in elderly, obese, hypertensive and diabetics. Severe grade of increase in LVMI was higher in patients with coronary artery tortuosity compared to those without coronary tortuosity. Similarly, LVMI can be useful echocardiographic predictor of coronary calcification as well as obstruction, further studies are warranted to explore pathophysiological basis and clinical impacts of these findings.
Abstract Figure.
Tail Beat Synchronization during Schooling Requires a Functional Posterior Lateral Line System in Giant Danios,Devario aequipinnatus
Authors: Mekdara Prasong J , Nasimi Fazila , Schwalbe Margot A B , Tytell Eric D 
Published: May 2021

AbstractSwimming in schools has long been hypothesized to allow fish to save energy. Fish must exploit the energy from the wakes of their neighbors for maximum energy savings, a feat that requires them to both synchronize their tail movements and stay in certain positions relative to their neighbors. To maintain position in a school, we know that fish use multiple sensory systems, mainly their visual and flow sensing lateral line system. However, how fish synchronize their swimming movements in a school is still not well understood. Here, we test the hypothesis that this synchronization may depend on functional differences in the two branches of the lateral line sensory system that detects water movements close to the fish’s body. The anterior branch, located on the head, encounters largely undisturbed free-stream flow, while the posterior branch, located on the trunk and tail, encounters flow that has been affected strongly by the tail movement. Thus, we hypothesize that the anterior branch may be more important for regulating position within the school, while the posterior branch may be more important for synchronizing tail movements. Our study examines functional differences in the anterior and posterior lateral line in the structure and tail synchronization of fish schools. We used a widely available aquarium fish that schools, the giant danio, Devario equipinnatus. Fish swam in a large circular tank where stereoscopic videos recordings were used to reconstruct the 3D position of each individual within the school and to track tail kinematics to quantify synchronization. For one fish in each school, we ablated using cobalt chloride either the anterior region only, the posterior region only, or the entire lateral line system. We observed that ablating any region of the lateral line system causes fish to swim in a “box” or parallel swimming formation, which was different from the diamond formation observed in normal fish. Ablating only the anterior region did not substantially reduce tail beat synchronization but ablating only the posterior region caused fish to stop synchronizing their tail beats, largely because the tail beat frequency increased dramatically. Thus, the anterior and posterior lateral line system appears to have different behavioral functions in fish. Most importantly, we showed that the posterior lateral line system played a major role in determining tail beat synchrony in schooling fish. Without synchronization, swimming efficiency decreases, which can have an impact on the fitness of the individual fish and group.
Biology’s best friend: Bridging disciplinary gaps to advance canine science
Authors: Bryce Authors: Caleb M , Davis Michael S , Gompper Matthew E , Hurt Aimee , Koster Jeremy M , Larson Greger , Ostrander Elaine A , Udell Monique A R , Urfer Silvan , Wirsing Aaron J , Jimenez Ana G 
Published: May 2021

Abstract
The rich history and global abundance of domestic dogs (Canis familiaris) present a unique opportunity and an ideal model for interdisciplinary research. Canine evolutionary history demonstrates unprecedented changes across all levels of biological organization. These include diversification from highly social, pack-dwelling wild carnivores (extant gray wolves, C. lupus), to increased dependence on humans (domestication), to modern in-home colonization featuring close physical proximity to humans (interspecies bonding). The young, emerging field of “canine science” comprises diverse biological disciplines including evolution, genetics, cognition, behavior, physiology, comparative medicine, and ecology, drawing on studies of both natural and experimental systems and scaling across all levels of biological organization, from genomes to ecosystems. However, limited connections bridge the various fields associated with canine science, although in every branch it is recognized that this species is one of the most phenotypically variable mammals. Yet there has been growing interest in integrating the insights from genomic evolution with those from ecophysiology and ecology, thus facilitating a more biologically comprehensive perspective of dogs. In particular, integrative, mechanistic, and/or ecological studies have been generally underrepresented. To address these emerging interests, we have collected the most compelling questions in the field of canine biology and present avenues of current and future research. This paper serves to both orient the reader to this special issue, as well as offer a forward-looking perspective from diverse biological sub-disciplines to highlight current and future goals in canine research.
The Extremal Number of Surfaces
Authors: Kupavskii Andrey , Polyanskii Alexandr , Tomon István , Zakharov Dmitriy 
Published: May 2021

Abstract
In 1973, Brown, Erdős and Sós proved that if $\mathcal{H}$ is a 3-uniform hypergraph on $n$ vertices which contains no triangulation of the sphere, then $\mathcal{H}$ has $O(n^{5/2})$ edges, and this bound is the best possible up to a constant factor. Resolving a conjecture of Linial, also reiterated by Keevash, Long, Narayanan and Scott, we show that the same result holds for triangulations of the torus. Furthermore, we extend our result to every closed orientable surface $\mathcal{S}$.
On the Benefits of Using MVC Pattern for Structuring Event-B Models of WIMP Interactive Applications
Authors: Singh Neeraj Kumar , Aït-Ameur Yamine , Geniet Romain , Méry Dominique , Palanque Philippe 
Published: May 2021

Abstract
This paper presents a formal development approach for designing interactive applications using a correct-by-construction approach. In this work, we propose a refinement strategy using model-view-controller (MVC) to structure and design Event-B formal models of the interactive application. The proposed MVC-based refinement strategy facilitates the development of an abstract model and a series of refined models by introducing the possible modes, controller’s behaviour and visual components of the interactive application while preserving the required interaction-related safety properties. To demonstrate the effectiveness, scalability, reliability and feasibility of our approach, we use a small example (from automotive domain) and real-life industrial case studies (from aviation). The entire development is realized in Event-B and the associated Rodin tool is used to analyse and verify the correctness of the formalized model. Finally, the developed Event-B models are used to generate source code using EB2ALL tool for going from the specification to the implementation of the interactive application.
Effects of early high nutrition related to metabolic imprinting events on growth, carcass characteristics, and meat quality of grass-fed Wagyu (Japanese Black cattle)
Authors: Khounsaknalath Sithyphone , Etoh Kotaro , Sakuma Kaori , Saito Kunihiko , Saito Akira , Abe Tsuyoshi , Ebara Fumio , Sugiyama Toshie , Kobayashi Eiji , Gotoh Takafumi 
Published: May 2021

Abstract
The study was conducted to clarify how early high plane of nutrition related to metabolic imprinting affected growth, carcass characteristics, and meat quality of grass-fed Wagyu (Japanese Black cattle). Wagyu steers were allocated randomly into 2 dietary groups: (1) steers fed milk replacer (crude protein 26.0%, crude fat 25.5%; maximum intake 0.6 kg/d) until 3 mo of age and then fed roughage (orchard grass hay) ad libitum from 4 to 10 mo of age (roughage group, RG; n = 11); (2) steers fed milk replacer (maximum intake of 1.8 kg/d) until 3 mo of age and then fed a high-concentrate diet from 4 to 10 mo of age (early high nutrition, EHN; n = 12). After 11 mo of age, all steers were fed roughage ad libitum until 31 mo of age and then slaughtered. Growth performance, carcass traits, longissimus muscle (LM) meat quality and intramuscular fat (IMF) content, plasma insulin-like growth factor I (IGF-I) concentration, and bone mineral density were measured. Body weight was greater in EHN steers (571 kg) than RG steers (520 kg; P &lt; 0.01). Plasma IGF-I levels were higher in EHN steers than in RG steers at 3, 10, and 14 mo of age (P &lt; 0.01, P &lt; 0.005, P &lt; 0.001, respectively); however, plasma IGF-I levels were lower in EHN steers compared with RG steers at 30 mo of age (P &lt; 0.01). The total weight of the muscles and bones of the left half of the carcass was not different between the 2 groups (P = 0.065). Five of the 19 muscles investigated (semimembranosus, P = 0.036; infraspinatus, P = 0.024; supraspinatus, P = 0.0019; serratus ventralis cervicis, P = 0.032; serratus ventralis thoracis, P = 0.027) were heavier in EHN steers. Total fat weight in the left half of the carcass was 30% greater (P = 0.025) in HNE carcasses. Subcutaneous and perirenal fat weights were 53% and 84% greater (P = 0.008, P = 0.002, respectively) in EHN carcasses. The LM IMF content was greater in EHN loins (13.2%) compared with RG loins (9.4%) at 31 mo of age (P = 0.038); however, no differences were found for shear force, tenderness, and cook loss. These results suggested early high-nutrition affected the growth and meat quality of livestock.
Efficient induction of proximity-dependent labelling by biotin feeding in BMAL1-BioID knock-in mice
Authors: Murata Kazuya , Mimura Asuka , Suzuki Hayate , Mikami Natsuki , Hamada Yuko , Kato Kanako , Iki Natsumi , Ishida Miyuki , Daitoku Yoko , Tanimoto Yoko , Okiyoneda Tsukasa , Fujiyama Tomoyuki , Dinh Tra Thi Huong , Mizuno Seiya , Sugiyama Fumihiro 
Published: May 2021

Abstract
Proximity-dependent biotin identification (BioID) is a useful method to identify unknown protein–protein interactions. Few reports have described genetically engineered knock-in mouse models for in vivo BioID. Thus, little is known about the proper method for biotin administration and which tissues are applicable. Here, we established a BioID knock-in mouse model of Brain and Muscle ARNT-Like 1 (BMAL1) and the BirA biotin ligase with R118G mutation (BirA*). The BMAL1-BioID mouse model was used to investigate the effect of biotin diet feeding on protein biotinylation in several tissues. The BMAL1-BirA* fusion protein-retained proper intracellular localization of BMAL1 and binding to CLOCK protein in HEK293T cells. A biotin labelling assay in mouse embryonic fibroblasts revealed the protein biotinylation activity of BMAL1-BirA* expressed in knock-in mouse cells depending on biotin supplementation. Lastly, feeding a 0.5% biotin diet for 7 days induced protein biotinylation in the brain, heart, testis and liver of BMAL1-BioID mice without adverse effects on spermatogenesis. In the kidney, the biotin diet increased biotinylated protein levels in BMAL1-BioID and control mice, suggesting the existence of endogenous biotinylation activity. These results provide valuable information to optimize the in vivo BioID procedure.
Presumptive stridulatory organs inParanthuracf.japonicaRichardson, 1909 (Isopoda: Cymothoida: Paranthuridae)
Authors: Kakui Keiichi , Shiraki Shoki 
Published: May 2021

AbstractMorphological diversity of sound-producing structures has not been well investigated among members of superorder Peracarida. Presumptive stridulatory sound-producing organs have been reported in some amphipods and tanaidaceans, and sound production by these organs has been documented in two isopod species in Oniscidea and Sphaeromatidea. We describe three presumptive stridulatory organs in the paranthurid isopod Paranthura cf. japonica Richardson, 1909, the first case known in Cymothoida. One type, consisting of a scale-bearing knob on the posterolateral corner of a pereonite and the scale-bearing anterolateral corner of the succeeding pereonite, was found between two pairs of pereonites (1, 2 and 2, 3). A second type involves a serrated structure in the sub-posterolateral region of pereonites 1 and 2, with the sharp anterolateral margins of pereonites 2 and 3 appearing to provide corresponding plectra. The third type involves an extension bearing a pair of serrated structures on the posteroventral margin of pereonites 1 and 2; the anterior-ventrolateral edges of pereonites 2 and 3 appear to provide corresponding plectra. All three organs occurred in both sexes of P. cf. japonica. Our discovery of novel, presumptive stridulatory organs in an intertidal isopod indicates that much remains to be learned about the biology of even common peracarid species.
The Contribution of Gestures to the Semantics of Non-Canonical Questions
Authors: Ippolito Michela 
Published: May 2021

AbstractThe symbolic gesture MAT (mano a tulipano) used by native speakers of Italian characterizes non-canonical wh questions when used both as a co-speech and pro-speech gesture. MAT can be executed with either a fast tempo contour or a slow tempo contour. Tempo is semantically significant: descriptively, a fast tempo characterizes a biased but information-seeking non-canonical question; a slow tempo characterizes a rhetorical non-canonical question. I argue that the fast contour is the default tempo of MAT and that it brings about a biased interpretation. Slowing down the movement occurs when the feature [slow] is added: the semantic contribution of this feature is to add the presupposition that the question is resolved in the conversational context, resulting in the rhetorical interpretation of the question.
A rare case of Mayer-Rokitansky-Küster-Hauser syndrome with right ovarian torsion and hypoplasia of the left adnexa
Authors: Masoumi Shahrbabak Maryam , Ebrahimi Meimand Faridadin 
Published: May 2021

Abstract
The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital disorder caused by the abnormal absence of paramesonephric ducts. The main characteristics of this syndrome include hypoplasia or aplasia of the uterus, absence of the cervix and upper part of vagina. Otherwise, ovaries and fallopian tubes have normal functions. A 9-year-old girl presented to the emergency department by acute abdominal pain. Based on a high probable diagnosis of ovarian torsion, surgical exploration was accomplished demonstrating rudimentary or aplastic uterus, hypoplasia of the left adnexa and torsion of the right ovary. In consideration of MRKH syndrome, further assessments were done and the diagnosis was confirmed.
As this syndrome is rare and there is a probability of ovarian torsion caused by malformation of the ovarian ligament, physicians should be aware of this syndrome to diagnose it earlier and preserve the ovarian tissue.
The shape and scatter of the galaxy main sequence for massive galaxies at cosmic noon
Authors: Sherman Sydney , Jogee Shardha , Florez Jonathan , Finkelstein Steven L , Ciardullo Robin , Wold Isak , Stevans Matthew L , Kawinwanichakij Lalitwadee , Papovich Casey , Gronwall Caryl 
Published: May 2021

ABSTRACT
We present the main sequence for all galaxies and star-forming galaxies for a sample of 28 469 massive (M⋆ ≥ 1011 M⊙) galaxies at cosmic noon (1.5 &lt; z &lt; 3.0), uniformly selected from a 17.5 deg2 area (0.33 Gpc3 comoving volume at these redshifts). Our large sample allows for a novel approach to investigating the galaxy main sequence that has not been accessible to previous studies. We measure the main sequence in small mass bins in the SFR–M⋆ plane without assuming a functional form for the main sequence. With a large sample of galaxies in each mass bin, we isolate star-forming galaxies by locating the transition between the star-forming and green valley populations in the SFR–M⋆ plane. This approach eliminates the need for arbitrarily defined fixed cutoffs when isolating the star-forming galaxy population, which often biases measurements of the scatter around the star-forming galaxy main sequence. We find that the main sequence for all galaxies becomes increasingly flat towards present day at the high-mass end, while the star-forming galaxy main sequence does not. We attribute this difference to the increasing fraction of the collective green valley and quiescent galaxy population from z = 3.0 to z = 1.5. Additionally, we measure the total scatter around the star-forming galaxy main sequence and find that it is ∼0.5–1.0 dex with little evolution as a function of mass or redshift. We discuss the implications that these results have for pinpointing the physical processes driving massive galaxy evolution.
The cosmology dependence of galaxy clustering and lensing from a hybrid N-body–perturbation theory model
Authors: Kokron Nickolas , DeRose Joseph , Chen Shi-Fan , White Martin , Wechsler Risa H 
Published: May 2021

ABSTRACT
We implement a model for the two-point statistics of biased tracers that combines dark matter dynamics from N-body simulations with an analytic Lagrangian bias expansion. Using Aemulus, a suite of N-body simulations built for emulation of cosmological observables, we emulate the cosmology dependence of these non-linear spectra from redshifts z = 0 to z = 2. We quantify the accuracy of our emulation procedure, which is sub-per cent at $k=1\, h \,{\rm Mpc}^{-1}$ for the redshifts probed by upcoming surveys and improves at higher redshifts. We demonstrate its ability to describe the statistics of complex tracer samples, including those with assembly bias and baryonic effects, reliably fitting the clustering and lensing statistics of such samples at redshift z ≃ 0.4 to scales of $k_{\rm max} \approx 0.6\, h\,\mathrm{Mpc}^{-1}$. We show that the emulator can be used for unbiased cosmological parameter inference in simulated joint clustering and galaxy–galaxy lensing analyses with data drawn from an independent N-body simulation. These results indicate that our emulator is a promising tool that can be readily applied to the analysis of current and upcoming data sets from galaxy surveys.