bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized blood pressure targets in the postoperative care of patients with intracerebral hemorrhage
Authors: Lindner Anna , Rass Verena , Ianosi Bogdan-Andrei , Schiefecker Alois Josef , Kofler Mario , Gaasch Max , Addis Alberto , Rhomberg Paul , Pfausler Bettina , Beer Ronny , Schmutzhard Erich , Thomé Claudius , Helbok Raimund 
Published: April 2021

OBJECTIVE
Recent guidelines recommend targeting a systolic blood pressure (SBP) < 140 mm Hg in the early management of patients with spontaneous intracerebral hemorrhage (ICH). The optimal SBP targets for ICH patients after hematoma evacuation (HE) remain unclear. Here, the authors aimed to define the optimal SBP range based on multimodal neuromonitoring data.

METHODS
Forty poor-grade ICH patients who had undergone HE and then monitoring of intracerebral pressure, brain tissue oxygen tension (PbtO2), and cerebral metabolism (via cerebral microdialysis [CMD]) were prospectively included. Episodes of brain tissue hypoxia (BTH) (1-hour averaged PbtO2 < 20 mm Hg) and metabolic distress (CMD–lactate/pyruvate ratio [LPR] ≥ 40) were identified and linked to corresponding parameters of hemodynamic monitoring (SBP and cerebral perfusion pressure [CPP]). Multivariable regression analysis was performed using generalized estimating equations to identify associations between SBP levels, PbtO2, and brain metabolism.

RESULTS
The mean patient age was 60 (range 51–66) years and the median [IQR] initial ICH volume was 47 [29–60] ml. In multivariable models adjusted for Glasgow Coma Scale score, probe location, ICH volume, and age, lower SBP was independently associated with a higher risk of BTH (≤ 120 mm Hg: adjusted OR 2.9, p = 0.007; 120–130 mm Hg: adj OR 2.4, p = 0.002; 130–140 mm Hg: adj OR 1.6, p = 0.017) compared to a reference range of 140–150 mm Hg at the level of the foramen interventriculare Monroi, which corresponded to a CPP of 70–80 mm Hg and SBP levels between 150 and 160 mm Hg at the heart level. After exclusion of episodes with mitochondrial dysfunction, SBP targets < 140 mm Hg were associated with higher odds of cerebral metabolic distress (≤ 130 mm Hg: OR 2.5, p = 0.041; 130–140 mm Hg: OR 2.3, p = 0.033). Patients with a modified Rankin Scale score ≥ 5 at neurological ICU discharge more often exhibited BTH than patients with better outcomes (51% vs 10%, p = 0.003).

CONCLUSIONS
These data suggest that lower SPB and CPP levels are associated with a higher risk for BTH. Further studies are needed to evaluate whether a higher SPB target may prevent BTH and improve outcomes.
Mortality and functional outcome after pediatric intracerebral hemorrhage: cohort study and meta-analysis
Authors: Boulouis Grégoire , Stricker Sarah , Benichi Sandro , Hak Jean-François , Gariel Florent , Kossorotoff Manoelle , Garcelon Nicolas , Harroche Annie , Alias Quentin , Garzelli Lorenzo , Bajolle Fanny , Boddaert Nathalie , Meyer Philippe , Blauwblomme Thomas , Naggara Olivier 
Published: April 2021

OBJECTIVE
The clinical outcome of pediatric intracerebral hemorrhage (pICH) is rarely reported in a comprehensive way. In this cohort study, systematic review, and meta-analysis of patients with pICH, the authors aimed to describe the basic clinical outcomes of pICH.

METHODS
Children who received treatment for pICH at the authors’ institution were prospectively enrolled in the cohort in 2008; data since 2000 were retrospectively included, and data through October 2019 were analyzed. The authors then searched PubMed and conducted a systematic review of relevant articles published since 1990. Data from the identified populations and patients from the cohort study were pooled into a multicategory meta-analysis and analyzed with regard to clinical outcomes.

RESULTS
Among 243 children screened for inclusion, 231 patients were included. The median (IQR) age at ictus was 9.6 (4.6–12.5) years, and 128 patients (53%) were male. After a median (IQR) follow-up of 33 (13–63) months, 132 patients (57.4%) had a favorable clinical outcome, of whom 58 (44%) had no residual symptoms. Nineteen studies were included in the meta-analysis. Overall, the proportion of children with complete recovery was 27% (95% CI 19%–36%; Q = 49.6; I2 = 76%); of those with residual deficits, the complete recovery rate was 48.1% (95% CI 40%–57%; Q = 75.3; I2 = 81%). When pooled with the cohort study, the aggregate case-fatality rate at the last follow-up was 17.3% (95% CI 12%–24%; Q = 101.6; I2 = 81%).

CONCLUSIONS
Here, the authors showed that 1 in 6 children died after pICH, and the majority of children had residual neurological deficits at the latest follow-up. Results from the cohort study also indicate that children with vascular lesions as the etiology of pICH had significantly better clinical functional outcomes.
The Secret of Ishango Bones – On the helix structure of prime numbers
Authors: Born Christof 
Published: April 2021

The Ishango bones were found in the 1950s by Belgian archaeologist Jean de Heinzelin near a Palaeolithic residence in Ishango, Africa. The inscriptions in the bones, which can be interpreted as numbers, are unique in their complexity in human history. Interestingly, on one of the two Ishango bones, we also find the six consecutive prime numbers 5, 7, 11, 13, 17 and 19. Did Stone Age people already know the secret of the prime numbers? This question is explored in my mathematical essay “The Secret of Ishango Bones”, an adventurous journey around the world from Basel in Switzerland to Erode in India. The presumed connection between the numbers on the Ishango bones and the structure of the prime numbers is illustrated by a sketch at the end of the text. Are the prime numbers organized as a double helix like DNA? Where did the people of Ishango get this knowledge? Did they perhaps have visits from aliens? As the physicist and mathematician Freeman John Dyson said so beautifully: “For any speculation which does not at first glance look crazy, there is no hope.”
UPAYA PEMERINTAH DALAM MENANGGULANGI KELANGKAAN ARSIPARIS DI INDONESIA
Authors: Agustina Gina 
Published: April 2021

Artikel ini berjudul Upaya Pemerintah dalam Menanggulangi Kelangkaan Arsiparis di Indonesia yang bertujuan untuk mengetahui apa saja upaya-upaya pemerintah dalam menanggulangi kelangkaan arsiparis di Indonesia. Pada artikel ini menggunakan metode kualitatif deskriptif dengan studi pustaka sebagai teknik pengumpulan data. Hasilnya menunjukan bahwa upaya pemerintah dalam menanggulangi kelangka arsiparis dengan menyediakan pendidikan formal kearsipan yang bekerjasama dengan berbagai perguruan tinggi negeri seperti Universitas Indonesia, Universitas Gajah Mada, Universitas Negeri Padang. Upaya berikutnya dengan mencanangkan pendirian Sekolah Tinggi Kearsipan kemudian dengan melaksanakan pembinaan kearsipan yang dilaksanakan ANRI, pihak yang terlibat antara lain Pemerintah Provinsi, Pemerintah Daerah dengan menerapkan Peraturan Pemerintah Republik Indonesia nomor 28 tahun 2012 tentang pelaksanaan Undang-undang Republik Indonesia nomor 43 tahun 2009 tentang kearsipan.
PRESERVASI KOLEKSI KASET VIDEO LANGKA KE DALAM BENTUK DIGITAL MELALUI PROSES ALIH MEDIA (Studi Kasus di UPT Perpustakaan ISI Surakarta)
Authors: Sulistyo Eko 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui proses pemindahan media koleksi kaset video ke dalam bentuk digital sebagai pengawet dan untuk mengetahui pengawetan kaset video menggunakan salah satu software. Penelitian ini merupakan penelitian kualitatif, dengan metode pengumpulan data melalui observasi, studi pustaka dan dokumen. Selain menggunakan metode kualitatif, peneliti juga menggunakan metode partisipatif untuk melestarikan digitalisasi, pustakawan akan terlibat langsung dan berpartisipasi dalam perencanaan proses pelestarian berdasarkan analisis sosial atau permasalahan di lapangan. Cara pengawetan ini berbeda, karena objek yang dipelajari atau dipindahkan adalah kaset video langka yang terdapat di Perpustakaan ISI Surakarta. Proses pengawetan memerlukan penanganan khusus, harus melalui tahapan pra transfer media yang biasa dilakukan dalam persiapan, antara lain: 1) Menyiapkan daftar koleksi kaset video yang akan diawetkan 2) Memilih prioritas atau koleksi prioritas yang sangat urgen sebagai media pembelajaran di ISI Surakarta. 3) Memilih sumber daya manusia yang ahli di bidang pelestarian. 4) Diperlukan peralatan yang lebih baik terutama pada komputer dengan spesifikasi tinggi 5) Persiapan Infrastruktur. Strategi preservasi yang dilakukan UPT Perpustakaan ISI Surakarta adalah dengan mentransfer media dari koleksi kaset video ke dalam bentuk digital, media transfer ini terdiri dari 9 tahap dan menggunakan Software VEGAS Pro 16.0. Tahapan dalam transfer media kaset video adalah sebagai berikut: 1) Membuka program software VEGAS Pro 16.0. 2) Capture koleksi video yang ditransfer. 3) Pemilihan Format Video. 4) Proses Pengambilan Video. 5) Mengedit Proses Pembuatan Menu. 6) Proses Impor Data Video. 7) Pengambilan File Dokumen Video. 8) Proses Pengeditan Video. 9) Proses Rendering Video.
Green Guerrillas and Counterinsurgent Environmentalists in the Petén, Guatemala
Authors: Andersson Anthony 
Published: April 2021

Abstract
At the peak of Guatemala's 36-year civil war (1960-1996), fought between a right-wing authoritarian regime and leftist guerrillas, the army massacred tens of thousands of Maya peasants in a genocidal counterinsurgency. The scorched earth campaign halted the insurgency's momentum, but the army was unable to secure political or military control in the large area of northern lowlands called El Petén. This essay examines how, at this critical juncture, the insurgents and the army embraced distinct environmentalist platforms and land-use policies in order to gain a strategic advantage. It argues that the army won a discursive battle, with assistance from big international conservation NGOs, to claim itself as the only legitimate 'defender of the forests'. This enabled the military to consolidate its position against the insurgents in the northern lowlands, contributing to its de facto victory in the war, as well as fuelling ongoing violence in the postwar.
Fire and Power on the River Basin: Irregular Warfare and Socio-Environmental Consequences of the Guerrilla in Araguaia, Brazil
Authors: de Majo Claudio 
Published: April 2021

Abstract
The aim of this article is to retrace a guerrilla episode that occurred in the Amazon region of Araguaia during the military dictatorship in Brazil (1972-1975), opposing a group of militants from the Communist Party of Brazil (PCdoB) and the National Brazilian Army. Taking advantage of the geographical characteristics of the region, a small group of guerrilla fighters was able to confront a large military contingent for almost three years. As this article demonstrates, appealing to the powerful symbolic potential of the Amazon jungle, the guerrilla created a solid environmental narrative of force and shrewdness supported by the local population. However, as military forces began to better explore the region and to resort to irregular warfare strategies, they managed to curb the guerrilla, exterminating almost every member involved in the fight. Finally, this article looks at the marked socio-environmental scars that the conflict left in the region, and how these influenced social, political and ecological equilibriums during the following decades.
The Maya Forest and Indigenous Resistance during the Caste War
Authors: Pretel David 
Published: April 2021

Abstract
This article provides an environmental history of indigenous resistance during the Caste War, a major Indian revolt that took place in the Yucatán peninsula between 1847 and 1901. It argues that the evolution of the war was bound to the material conditions of the vast Maya rainforest and the expanding built environment at this area's commodity frontiers. In this regard, the article advances two main theses. First, that the Maya rainforest was an ideal battleground for the insurgents' guerrilla warfare but extremely challenging for regular military columns. Second, that indigenous subversion and survival rested on both commodity extraction and everyday agricultural practices carried out in the forest. In short, indigenous resistance was built on the ecology and geography of the rainforest at the contested interstices of empires and nations.
The Enduring Climate of Conflict: Drought, Impoverishment and the Long Aftermath of Civil War in Peru
Authors: Puente Javier 
Published: April 2021

Abstract
This article explores the relationship and correlation between climate and conflict in the contemporary Peruvian Andes before, during, and in the aftermath of the most recent civil conflict (1980-2000). Based on the combination of climatological data related to the 1982-1983 El Niño, personal testimonies, and other source documents, the following pages unpack the ecological meaning of the campesino condition as a foundational element preceding the conflict, as the pivotal object and subject of escalating social violence, and as the chief outcome of insurrectionary and counter-insurrectionary terror.
The use of high dose octreotide in management of neonatal chylothorax: Review
Authors: Alhasoon M.A. 
Published: April 2021

BACKGROUND: Being a rare condition, the incidence of chylothorax among neonates is low, but the mortality rate is high. In a dire effort to reduce the risk of death, octreotide treatment is used to effectively treat acquired and congenital chylothorax. Octreotide is proven to effectively treat chylothorax in pre-term and full-term neonates. However, previous studies have not consistently demonstrated the optimal dose of octreotide or the best mode of administration. The objectives of this work were to review previous literature to determine the outcomes of administering high doses of octreotide compared to lower dose regimens in neonates with chylothorax and to determine best practices. METHODS: A literature search was performed using electronic databases using the key words neonates, chylothorax, and octreotide. RESULTS: Octreotide has been administrated in doses ranging from 0.5 μg/kg/h to > 20 μg/kg/h. Both low- and high-doses of octreotide are effective in resolving chylothorax with little to no side effects. When side effects were reported, neonates experienced side effects that are less significant in nature and scope. CONCLUSIONS: We recommend that the dose of octreotide in neonatal chylothorax can be titrated safely to a maximum of 20 μg/kg/h without significant side effects.
The impact of a transitional intervention for youth living with early psychosis: A mixed methods study
Authors: McCay Elizabeth , Tibbo Philip , Conrad Gretchen , Aiello Andria , Crocker Candice , Beanlands Heather , Schwind Jasna , Kirwan Nicole , Langley John , Sheasgreen Clare , Danaher Audrey 
Published: April 2021

Our research team implemented and evaluated a 12-week manual-based intervention focused on sustaining recovery for youth with psychosis, as they transitioned from Early Psychosis Intervention (EPI) to community-based care teams. The study employed a mixed methods prospective cohort design. Statistically significant improvement in functioning was observed for the intervention group participants only; as well as observed improvements in self-esteem and quality of life (SQLS), compared to the comparison group who demonstrated a significant decline in functioning. The qualitative findings revealed a sense of optimism about the future and the value of realistic goal-setting in the intervention group.
Keywords: Early Psychosis, Transitional Intervention, Recovery, Functioning, Goal-Setting
Publishing classification systems on the Internet: representation and use
Authors: Kononova E. V. , Sukiasyan E. R. 
Published: April 2021

Classification systems are published primarily in the book form, for various purposes and in different versions. They are identified by the number or year of publication. The authors propose another variant of maintaining classification systems, i.e. in the card format.The authors discuss the issues of presenting classification schedules of popular classification systems on the Internet with special focus on their applications. They explain why privately owned classification systems, like Dewey Decimal Classification (DDC) and Universal Decimal Classification (UDC), are not published on the Internet, while the systems supported by government organizations (e.g. national libraries) are traditionally published openly. The authors provide the example of the Library of Congress Classification (LCC), which is the United States’ National Classification System and which is published on open access. The project of the open presentation of the Library-Bibliographical Classification (LBC) in several versions supplemented with indices on the website of the Russian State Library (RSL) is described in more detail. The possibilities for their use are analyzed.
Impact of Thrombocytopenia in Patients With Atrial Fibrillation Undergoing Left Atrial Appendage Occlusion: A Propensity-Matched Comparison of 190 Consecutive Watchman Implantations
Authors: Zhang Xiaochun , Jin Qinchun , Hu Jialu , Kong Dehong , Pan Cuizhen , Chen Dandan , Chen Shasha , Li MIngfei , Zhou Daxin , Ge Junbo 
Published: April 2021

Objectives: The purpose of this study was to provide data on the long-term efficacy and safety of left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) and chronic thrombocytopenia (cTCP).Methods: Between January 2016 and December 2018, a total of 32 AF patients with thrombocytopenia (platelet count &lt;100*10∧9/L) undergoing LAAO at our center were identified and their outcomes were compared with a propensity-matched cohort (match ratio 1:5) of patients without cTCP who had also been indicated for LAAO.Results: Between the cTCP patients and the control group, no difference was found on the incidence of stroke (0 vs. 3.13%, p = 0.592), systematic thromboembolisation (0 vs. 0.63%, p &gt; 0.9) and device-related thrombus (DRT) (3.13 vs. 2.50%, p &gt; 0.9). Major (12.50 vs. 3.75%, p = 0.065) and minor bleeding (15.63 vs. 1.25%, p = 0.002) was more frequent in cTCP patients but no statistical difference was reached in major bleeding. Moreover, thrombocytopenia was also identified as an independent predictor of any bleeding events (OR: 8.150, 95% CI: 2.579–25.757, p &lt; 0.001), while an inverse relationship between higher absolute platelet count and stroke events was revealed (OR: 1.015; 95% CI: 1.002~1.029, p = 0.022). However, in both groups we saw a significant reduction in observed annualized rates of non-procedural complications compared with the predicted values. In the cTCP and control groups, clinical thromboembolism was reduced by 100 and 74.32%, and major bleeding by 42.47 and 71.67%, respectively.Conclusion: Our preliminary results indicate that LAAO using the Watchman device could be a safe and effective means of preventing stroke in AF patients with or without thrombocytopenia, but bleeding complications should be monitored intensively in cTCP patients.
The mTOR Deficiency in Monocytic Myeloid-Derived Suppressor Cells Protects Mouse Cardiac Allografts by Inducing Allograft Tolerance
Authors: Li Jiawei , Chen Juntao , Zhang Mingnan , Zhang Chao , Wu Renyan , Yang Tianying , Qiu Yue , Liu Jingjing , Zhu Tongyu , Zhang Yi , Rong Ruiming 
Published: April 2021

BackgroundMyeloid-derived suppressor cells (MDSCs) can prevent allograft rejection and induce immune tolerance in transplantation models. Previous studies have demonstrated that inhibition of mTOR signaling can enhance the MDSC protective effect in heart transplantation (HTx) by promoting MDSC expansion. In addition, mTOR inhibition is related to autophagy. The present study investigated the protective mechanism of mTOR-deficient monocytic MDSCs (M-MDSCs) in mouse HTx.MethodsMyeloid-specific mTOR conditional knockout mice were generated to obtain mTOR−/− M-MDSCs. The proliferation and immunosuppressive function of mTOR−/− M-MDSCs were determined by flow cytometry and T cell proliferation assays. The mTOR−/− M-MDSC intracellular autophagy levels were determined using western blotting and electron microscopy. RNAseq analysis was performed for wild-type (WT) and mTOR−/− M-MDSCs. Allogeneic HTx mouse model was established and treated with WT or mTOR−/− M-MDSCs. Enzyme-linked immunosorbent assay, flow cytometry, and immunohistochemistry assays were performed to determine WT and mTOR−/− M-MDSC-induced immune tolerance.ResultsThe mTOR deficiency promoted M-MDSC differentiation and enhanced intracellular autophagy levels in vivo and in vitro. mTOR deficiency also enhanced the immunosuppressive function of M-MDSCs. In addition, infusing with WT and mTOR−/− M-MDSCs prolonged cardiac allograft survival and established immune tolerance in recipient mice by inhibiting T cell activation and inducing regulatory T cells.ConclusionmTOR deficiency enhances the immunosuppressive function of M-MDSCs and prolongs mouse cardiac allograft survival.
Frequency, Progression, and Current Management: Report of 16 New Cases of Nonfunctional Pancreatic Neuroendocrine Tumors in Tuberous Sclerosis Complex and Comparison With Previous Reports
Authors: Mowrey Kate , Northrup Hope , Rougeau Peyton , Hashmi S. Shahrukh , Krueger Darcy A. , Ebrahimi-Fakhari Daniel , Towbin Alexander J. , Trout Andrew T. , Capal Jamie K. , Franz David Neal , Rodriguez-Buritica David 
Published: April 2021

Background: Tuberous sclerosis complex (TSC) is a genetic condition that causes benign tumors to grow in multiple organ systems. Nonfunctional pancreatic neuroendocrine tumors (PNETs) are a rare clinical feature of TSC with no specific guidelines outlined for clinical management at this time. Our purpose is to calculate the frequency of nonfunctional PNETs as well as characterize the presentation, current clinical management, and assess the impact of systemic mammalian target of rapamycin (mTOR) on nonfunctional PNETs in TSC.Methods: This retrospective chart review was performed by a query of the TS Alliance's Natural History Database and the Cincinnati Children's Hospital TSC Database for patients with nonfunctional PNET. Clinical data from these two groups was summarized for patients identified to have a nonfunctional PNET and compared to previously reported cases with TSC and nonfunctional PNETs.Results: Our calculated frequency of nonfunctional PNETs is 0.65%. We identified 16 individuals, nine males and seven females, with a median age of 18.0 years (interquartile range: −15.5 to 25.5). Just over half (56.3%, n = 9) of the patients provided results from genetic testing. Six had pathogenic variants in TSC2 whereas three had pathogenic variants in TSC1. The average age at PNET diagnosis was 15.0 years (range: 3–46 years). Almost all individuals were diagnosed with a PNET during routine TSC surveillance, 56.3% (n = 9) by MRI, 12.5% (n = 2) by CT, 25% (n = 4) by ultrasound, and 6.2% (n = 1) through a surgical procedure. Follow up after diagnosis involved 68.8% (n = 11) having serial imaging and nine of the sixteen individuals proceeding with surgical removal of the PNET. Eight individuals had a history of using systemic mTOR inhibitors. Tumor growth rate was slightly less in individuals taking an mTOR inhibitor (−0.8 mm/yr, IQR: −2.3 to 2.2) than those without (1.6 mm/yr; IQR: −0.99 to 5.01, p &gt; 0.05).Conclusions: Nonfunctional PNETs occurred at younger ages in our TSC cohort and more commonly compared to ages and prevalence reported for the general population. PNETs in patients on systemic mTOR inhibitors had lower rates of growth. The outcome of this study provides preliminary evidence supporting the use of mTOR inhibitor therapy in conjunction with serial imaging as medical management for nonfunctional PNETs as an alternative option to invasive surgical removal.