bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Palm Oil Vitamin E in Preventing Pre-eclampsia: A Secondary Analysis of a Randomized Clinical Trial Following ISSHP Reclassification
Authors: Aminuddin Nurul Afzan , Sutan Rosnah , Mahdy Zaleha Abdullah 
Published: January 2021

Background: Preeclampsia is a significant cause of maternal and perinatal mortality worldwide. Oxidative stress plays a key role in its pathophysiology, hence antioxidants such as tocotrienol may be preventive against preeclampsia. In 2018, the ISSHP revised the definition of preeclampsia. In accordance with the new definition, we report a secondary data analysis from a clinical trial comparing palm oil vitamin E in the form of tocotrienol-rich fraction (TRF) against placebo, in preventing preeclampsia.Method: A randomized double-blind controlled trial was conducted in 2002–2005 to assess the benefits of TRF in preeclampsia prevention. A total of 299 primigravidae were recruited. The intervention group was supplemented with TRF 100 mg daily in super-olein capsules, whereas the placebo group was prescribed super-olein capsules without TRF, beginning from 12 to 16 gestational weeks until delivery. The primary outcome measure was incidence of preeclampsia.Results: The total incidence of pregnancy induced hypertension (PIH) was 5%, whereas the incidence of preeclampsia was 2.3%. The odds of developing PIH (adjusted OR 0.254; 95% CI: 0.07–0.93; p–value 0.038) and preeclampsia (adjusted OR 0.030; 95% CI: 0.001–0.65; p-value 0.025) were significantly lower in the TRF arm compared to the placebo arm.Conclusion: Antenatal supplementation with palm oil vitamin E in the form of TRF is associated with significant reductions in the incidence of preeclampsia and PIH in a single urban tertiary hospital. Palm oil vitamin E deserves further scrutiny as a potential public health preventive measure against preeclampsia and PIH.
Alzheimer’s Disease Projection From Normal to Mild Dementia Reflected in Functional Network Connectivity: A Longitudinal Study
Authors: Sendi Mohammad S. E. , Zendehrouh Elaheh , Miller Robyn L. , Fu Zening , Du Yuhui , Liu Jingyu , Mormino Elizabeth C. , Salat David H. , Calhoun Vince D. 
Published: January 2021

BackgroundAlzheimer’s disease (AD) is the most common age-related problem and progresses in different stages, including mild cognitive impairment (early stage), mild dementia (middle-stage), and severe dementia (late-stage). Recent studies showed changes in functional network connectivity obtained from resting-state functional magnetic resonance imaging (rs-fMRI) during the transition from healthy aging to AD. By assuming that the brain interaction is static during the scanning time, most prior studies are focused on static functional or functional network connectivity (sFNC). Dynamic functional network connectivity (dFNC) explores temporal patterns of functional connectivity and provides additional information to its static counterpart.MethodWe used longitudinal rs-fMRI from 1385 scans (from 910 subjects) at different stages of AD (from normal to very mild AD or vmAD). We used group-independent component analysis (group-ICA) and extracted 53 maximally independent components (ICs) for the whole brain. Next, we used a sliding-window approach to estimate dFNC from the extracted 53 ICs, then group them into 3 different brain states using a clustering method. Then, we estimated a hidden Markov model (HMM) and the occupancy rate (OCR) for each subject. Finally, we investigated the link between the clinical rate of each subject with state-specific FNC, OCR, and HMM.ResultsAll states showed significant disruption during progression normal brain to vmAD one. Specifically, we found that subcortical network, auditory network, visual network, sensorimotor network, and cerebellar network connectivity decrease in vmAD compared with those of a healthy brain. We also found reorganized patterns (i.e., both increases and decreases) in the cognitive control network and default mode network connectivity by progression from normal to mild dementia. Similarly, we found a reorganized pattern of between-network connectivity when the brain transits from normal to mild dementia. However, the connectivity between visual and sensorimotor network connectivity decreases in vmAD compared with that of a healthy brain. Finally, we found a normal brain spends more time in a state with higher connectivity between visual and sensorimotor networks.ConclusionOur results showed the temporal and spatial pattern of whole-brain FNC differentiates AD form healthy control and suggested substantial disruptions across multiple dynamic states. In more detail, our results suggested that the sensory network is affected more than other brain network, and default mode network is one of the last brain networks get affected by AD In addition, abnormal patterns of whole-brain dFNC were identified in the early stage of AD, and some abnormalities were correlated with the clinical score.
Economic Evaluation Protocol and Statistical Analysis Plan for the Cost-Effectiveness of a Novel Australian Stroke Telemedicine Program; the Victorian Stroke Telemedicine (VST) program
Authors: Cadilhac Dominique A. , Sheppard Lauren , Kim Joosup , Tan Elise , Gao Lan , Sookram Garveeta , Dewey Helen M. , Bladin Christopher F. , Moodie Marj 
Published: January 2021

Introduction:Telemedicine can address limited access to medical specialists in rural hospitals. Stroke provides an important case study because: it is a major cause of disease burden; effective treatments to reduce disability (e.g., thrombolysis) can be provided within the initial hours of stroke onset; careful selection of patients is needed by skilled doctors to minimize adverse events from thrombolysis; and there are major treatment gaps (only about half of regional hospitals in Australia provide thrombolysis for stroke). Few economic analyses have been undertaken on telestroke and the majority have been simulation models. The aim of this protocol and statistical analysis plan is to outline the methods for the cost-effectiveness evaluation of a large, multicentre acute stroke telemedicine program being conducted in Victoria, Australia.Methods:Using a historical- and prospective-controlled design, we will compare patient-level data obtained in the 12 months prior to the Victorian Stroke Telemedicine (VST) program implementation and during the first 12 months of VST to determine the incremental difference in costs and patient outcomes at 3 and 12 months. Secondary aims include assessing the cost per additional patient receiving intravenous thrombolysis and the cost per additional patient receiving intravenous thrombolysis within 60 min. Tertiary aims include assessing the potential longer-term cost-effectiveness in the second year of the program at the hospitals to determine whether any program benefits are sustained once site coordinators are no longer employed; and modeling the potential net life-time costs and benefits from a societal perspective. Multivariable uncertainty and one-way sensitivity analyses will be performed to assess the robustness of results.Results:Sixteen hospitals participated. Patient-level data collection including 12-month outcomes for the cohorts obtained in the first and second year of the program for each hospital was completed in January 2020.Conclusion:The results from this real-world study with patient-level data will provide high quality evidence of the costs, health benefits and policy implications of telestroke programs, including the potential for application in other locations within Australia or other countries with similar health system delivery and financing.
Safety and Efficacy of Mechanical Thrombectomy Using Tigertriever as a Rescue Device After Failed Aspiration—Single Center Experience
Authors: Piasecki Piotr , Wierzbicki Marek , Narloch Jerzy 
Published: January 2021

Introduction: We evaluated the safety and efficacy of a new stent retriever—Tigertriever—after failed aspiration.Materials and Methods: Patients with acute ischemic stroke treated with Tigertriever between January 2018 and March 2020 were included in the study. Treatment results of Tigertriever in rescue therapy (after failed aspiration) were evaluated. Periprocedural data were retrospectively analyzed.Results: Thirty patients were treated with Tigertriever (14M/16F). There were 20 rescue thrombectomies after failed aspiration. Tigertriver successful recanalization rate (mTICI ≥ 2B) was 70%: 65% in rescue therapy and 80% in first-line therapy. The type of first line treatment had no impact on mRS after 1 month and 3 months (ns). There was significant improvement in NIHSS in all patients (mean NIHSS: 17 vs. 10, p = 0.028), in rescue treatment (mean NIHSS: 17 vs. 11, p = 0.048) and in first line treatment (mean NIHSS: 16 vs. 8, p = 0.0005). Better results in NIHSS at discharge were linked with first pass success (p = 0.002), better mTICI at the end of the procedure (p = 0.0006), and administration of rtPA (p = 0.013).Conclusions: The new stent retriever Tigertriever is an efficient and safe tool to be used as a rescue device after an unsuccessful first line aspiration technique.
Cognitive Processes Underlying Verbal Fluency in Multiple Sclerosis
Authors: Delgado-Álvarez Alfonso , Matias-Guiu Jordi A. , Delgado-Alonso Cristina , Hernández-Lorenzo Laura , Cortés-Martínez Ana , Vidorreta Lucía , Montero-Escribano Paloma , Pytel Vanesa , Matias-Guiu Jorge 
Published: January 2021

Background: Verbal fluency (VF) has been associated with several cognitive functions, but the cognitive processes underlying verbal fluency deficits in Multiple Sclerosis (MS) are controversial. Further knowledge about VF could be useful in clinical practice, because these tasks are brief, applicable, and reliable in MS patients. In this study, we aimed to evaluate the cognitive processes related to VF and to develop machine-learning algorithms to predict those patients with cognitive deficits using only VF-derived scores.Methods: Two hundred participants with MS were enrolled and examined using a comprehensive neuropsychological battery, including semantic and phonemic fluencies. Automatic linear modeling was used to identify the neuropsychological test predictors of VF scores. Furthermore, machine-learning algorithms (support vector machines, random forest) were developed to predict those patients with cognitive deficits using only VF-derived scores.Results: Neuropsychological tests associated with attention-executive functioning, memory, and language were the main predictors of the different fluency scores. However, the importance of memory was greater in semantic fluency and clustering scores, and executive functioning in phonemic fluency and switching. Machine learning algorithms predicted general cognitive impairment and executive dysfunction, with F1-scores over 67–71%.Conclusions: VF was influenced by many other cognitive processes, mainly including attention-executive functioning, episodic memory, and language. Semantic fluency and clustering were more explained by memory function, while phonemic fluency and switching were more related to executive functioning. Our study supports that the multiple cognitive components underlying VF tasks in MS could serve for screening purposes and the detection of executive dysfunction.
Toxic Nightlife Relationships, Substance Abuse, and Mental Health: Is There a Link? A Qualitative Case Study of Two Patients
Authors: Racionero-Plaza Sandra , Piñero León Juan Antonio , Morales Iglesias Manuel , Ugalde Leire 
Published: January 2021

Introduction and Aims: This article explores the role of toxic close relationships in night life on substance use disorders and mental health conditions. We also contrast the quality and effects of social relationships when doing drugs with those produced by a mental health program that fosters quality relationships between patients.Design and Methods: This qualitative case study was carried out at a mental health day care center of a hospital in Malaga (Spain). The cases of two patients with severe mental disorders and a history of drug addiction were analyzed. Data were collected through in-depth interviews with every patient, semi-structured interviews about each patient with the psychologist of the medical team of the program, and medical documentation. The analysis involved a combination of inductive and deductive approaches.Results: The analysis of the data revealed, on the one hand, the influence of toxic relationships in nightlife, including violent sporadic sexual relationships, in the initiation and persistence of substance use that took part of the mental health disorder in these patients. On the other hand, the findings show that these participants' current involvement in a mental health program, which fosters quality relationships between patients, has brought emotional benefits to both of them.Discussion and Conclusion: This paper points out the relevance of considering quality of social relationships when examining substance use disorders and related mental health problems. Additionally, the findings indicate the importance of fostering quality peer relationships in mental health rehabilitation programs addressed to patients with histories of drug addiction to improve treatment outcome.
Examining inquiry-based learning stages of concern for high school agriscience teachers
Authors: Conner Nathan , Reiling Bryan , Stripling Christopher T. , Kreifels Matt , Monheim Angie 
Published: January 2021

There is documented need for improvement of science comprehension amongst high school students in the United States, and inquiry-based learning (IBL) is a recommended teaching strategy to improve science comprehension. Several researchers have focused on examination of learning outcomes for students, but few have researched the concerns of teachers who may wish to adopt IBL methodology. This study used the stages of concern questionnaire to profile ten Midwest high school agriscience teachers’ concerns regarding implementation of IBL, before and after participation in a year-long professional development program where IBL lessons were developed and used in the participants’ high school classrooms. Results indicated that while some participants showed a positive progression in their stage of concern, most professional development program participants did not progress in their concern stage, and some developed increased resistance to IBL as a teaching strategy. This suggests that teachers may need more robust and tailored support when adopting IBL for their classrooms.
Pengaruh Promosi Terhadap Keputusan Pembelian Yang Di Mediasi Oleh Minat Beli Konsumen Roxy Swalayan Ende
Authors: Meme Roswita , Byre Rafael Octavianus 
Published: January 2021

This study aims to determine the effect of Promotion on:1) Customer Purchase Decisions at Roxy Swalayan Ende, 2) Purchasing Intention at Roxy Swalayan Ende, 3)Buying Interest on Customer Purchasing Decisions at Roxy Swalayan Ende, and 4)Promotion on Customer Decisions mediated by Buying Interest at Roxy Swalayan Ende. This research includes causality research using a quantitative approach. the samples in this study were customers who shop at Roxy Swalayan Ende amounting to 50 people. Data collection used a questionnaire while data analysis performed using Path Analysis. The data were collected using questionnaires that have been tested for validity and reliability. Path analysis was used to test the hypothesis of this study. The results of this study indicate that: 1)promotion has positive and significance influence on Customer Purchase Decisions with a beta Value of 0,469, 2) promotion has positive and significant effect on purchase intention at Roxy Swalayan with beta value of 0,582, 3)purchase intention has positive and significant influence on Customer purchasing decisions at Roxy Swalayan Ende with beta value of 0,438, 4) promotion has positive and significant effect on customer purchasing decisions mediated by buying interest has a beta value of 0,254
Analisis Efisiensi Dan Efektivitas Penggunaan Anggaran Pemeliharaan Jembatan Pada Dinas Pekerjaan Umum Kabupaten Ende
Authors: Meo Katarina , Londa Yulita , Ismail Nuraini 
Published: January 2021

The purpose of this study is to analyze the efficiency and effectiveness of the use of the bridge maintenance budget for the public works service of Ende district from 2015-2017. The data analysis used is quantitative analysis by calculating the efficiency and effectiveness of the bridge maintenance budget. The research has the character of explaining matters relating to hypothesis testing and in its descriptive nature it also contains descriptions used in the research, namely by collecting data.
The data collected in this study are the bridge construction budget data from 2015-2017 which were obtained from the Public Works Office of Ende Regency and data regarding the physical realization and realization of the district bridge construction budget in Ende Regency at the Public Works Office. The results of this study indicate that the budget and physical realization greatly influence the efficiency and effectiveness of bridge construction.
Sosialisasi Pemanfaatan Sampah Organik Menjadi Pupuk Cair Organik di Desa Binaan UMN
Authors: Wahjuwibowo Indiwan Seto 
Published: January 2021

Salah satu faktor pendukung aspek Smart Village adalah pengelolaan limbah masyarakat baik berupa sampah organik maupun anorganik. Pengelolaan sampah organik maupun anorganik merupakan suatu faktor pendukung utama. Apabila sampah ini tidak dikelola dengan baik, dapat mengakibatkan beberapa akibat yaitu: 1) Sampah bisa menyebabkan pencemaran udara karena terdapat gas-gas yang menimbulkan bau yang tidak sedap; 2) Penumpukan sampah mengakibatkan kondisi ketidaknyamanan kehidupan lingkungan sekitarnya; 3) minim oksigen terjadi karena selama proses perombakan sampah menjadi senyawa- senyawa yang diperlukan oksigen yang telah diambil dari udara sekitar tempat pembuangan sampah; 4) gas yang dihasilkan selama proses pembusukan sampah bisa membahayakan kesehatan karena bisa jadi sampah tersebut mengandung gas beracun; 5) menyebabkan terjadinya penularan penyakit melalui hewan, misalnya lalat atau serangga lain; 6) Tempat pembuangan sampah menjadi tempat yang kurang indah dipandang dan lingkungan tersebut tidak nyaman untuk ditempati. Itulah yang membuat sejumlah dosen di Universitas Multimedia Nusantara melakukan sosialisasi dan praktik mengubah sampah organic menjadi pupuk cair organic dengan teknik yang sederhana memanfaatkan barang-barang bekas yang ada di desa. pemanfaatan pupuk organik untuk tanah sangat membantu memperbaiki struktur tanah, meningkatkan permeabilitas tanah, dan mengurangi ketergantungan lahan pada pupuk anorganik. Selain itu, pupuk organik juga berperan sebagai sumber makanan bagi mikroorganisme tanah. Efek positifnya, dapat meningkatkan jumlah dan aktivitas mikroorganisme tanah sehingga tanah menjadi gembur dan mudah menyerap air
Pelatihan Pembuatan Pasta Bumbu Dapur Di Forum Kelompok Wanita Tani Sekar Arum Tangerang Selatan
Authors: Siregar Tagor M. , Soedirga Lucia , Sinaga Weny , Halim Yuniwati 
Published: January 2021

Forum kelompok wanita tani (KWT) Sekar Arum merupakan kelompok masyarakat di Tangerang Selatan yang kegiatan utamanya membudidayakan tanaman rempah-rempah dan tanaman hidroponik seperti sereh, jahe, kunyit, lengkuas, kencur dan bayam merah. Saat ini para anggota Forum KWT Sekar Arum Tangerang Selatan belum memiliki pengetahuan yang memadai tentang teknologi pengolahan pangan. Sebagai respon atas kondisi ini, Program Studi Teknologi Pangan UPH memberikan solusi berupa pelaksanaan pelatihan pembuatan pasta bumbu dapur. Kegiatan ini bertujuan agar masyarakat mampu memberdayakan bahan pangan lokal menjadi produk pangan yang dapat digunakan untuk kebutuhan sehari-hari dan bernilai ekonomi tinggi. Kegiatan ini dilakukan melalui tahap persiapan dan tahap pelaksanaan. Pada tahap persiapan dilakukan proses diskusi secara daring dengan pengurus Forum KWT Sekar Arum, proses uji coba di Laboratorium Pengolahan Pangan Program Studi Teknologi Pangan UPH dan persiapan akhir berupa pembuatan video pelatihan dan slide presentasi. Pelaksanaan pelatihan dilakukan secara webinar pada tanggal 18 Juni 2020 dan diikuti oleh 26 orang peserta. Sebagai dampak pelatihan, pembuatan pasta bumbu dapur dengan bahan pangan lokal menjadi salah satu alternatif kegiatan sehari-hari yang dilakukan oleh para anggota Forum KWTdi masa pandemi Covid 19. Pelatihan di Forum KWT Sekar Arum yang merupakan bentuk kerjasama antara Program Studi Teknologi Pangan UPH dengan Dinas Ketahanan Pangan, Pertanian dan Perikanan Kota Tangerang Selatan diharapkan dapat dilakukan secara berkala dan berkelanjutan dalam memberdayakan masyarakat.
Edukasi Penggunaan Masker Dan Handsanitizer Bagi Petugas Kebersihan Di Fakultas Kedokteran ULM
Authors: Kaidah Siti , Budiarti Lia Yulia , Yasmina Alfi , Heriyani Farida 
Published: January 2021

Edukasi Online Penggunaan Masker dan Hand Sanitizer bagi Tenaga Cleaning Service dan Satpam Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasi. Kota Banjarmasin termasuk salah satu kota provinsi dengan jumlah kasus covid-19 terbanyak di Indonesia. Pencegahan terhadap penularan covid-19, diantaranya dengan menerapkan protokol kesehatan berupa penggunaan masker dan mencuci tangan dengan hand sanitizer. Tenaga cleaning service dan satpam yang setiap hari bekerja di Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin, termasuk yang berisiko dapat terpapar covid-19. Kegiatan ini bertujuan untuk memberikan pengetahuan dan pemahaman tentang penerapan protokol kesehatan dalam mencegah penularan covid-19. Sasaran kegiatan ini adalah semua tenaga cleaning service dan satpam di FK ULM Banjarmasin. Metode pelaksanaan berupa pemberian edukasi online, dengan materi tentang penggunaan masker dan hand sanitizer, serta langkah-langkah mencuci tangan yang baik dan benar. Pada kegiatan ini juga disertai pembagian masker dan hand sanitizer. Hasil kegiatan, didapatkan peningkatan pengetahuan dan keterampilan dari sasaran. Diharapkan semua peserta kegiatan dapat senantiasa menerapkan protokol kesehatan terkait covid-19 didalam rumah tangga, masyarkat dan di lingkungan kerja.
Parenting Socialization: Efforts to Provide Parent Training at Bimbingan Belajar Ceria Karawaci , Tangerang
Authors: Prijanto Jossapat Hendra , Tirza Juliana 
Published: January 2021

Home care and education at school are important pillars of child development. Economic conditions, geographical position, educational background of parents, and the stigma that develops in society towards women who do not need to be highly educated have a significant effect on parenting patterns, especially mother-to-child care. In fact, not all Indonesian children receive proper care. Data from the National Service Agency (KOMNAS) for Children in 2006 showed that there were still 1,124 violence against children, 433 children experienced physical violence and 106 experienced psychological violence. Various bad facts about the concern for Indonesian children have encouraged UPH Lecturers to contribute in community service to provide training for parents of students at Bimbingan Belajar Ceria Karawaci , Tangerang. They come from families with low levels of education and difficulties. It is hoped that this training activity can provide insight into their parents and have an impact on the mindset of the community around Bimbingan Belajar Ceria regarding proper parenting for their children. Various efforts were made in community service in Bimbingan Belajar Ceria, stated in this paper. This paper aims to share awareness about the parental training efforts that have been carried out by Pelita Harapan University lecturers, with the hope of forming a smart and stable society. The result of this community service are the parents get many parental skills and the feedback are positive even they want this program to be continued and give more knowledge for them.

Keywords: parenting, community service, education