bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of remote delivery of clinical pharmacy services on health disparities and access to care
Authors: Emmons Roshni P. , Harris Ila M. , Abdalla Maha , Afolabi Titilola M. , Barner Amanda E. , Baxter Michael V. , Bisada Miriam , Chase Aaron M. , Christenberry Emily J. , Cobb Brooklyn T. , Dang Yen , Hickman Carolyn M. , Mills Alex R. , Wease Heather 
Published: October 2021

AbstractThe use of technology to deliver remote clinical pharmacy services can help broaden the patient reach and improve health‐related outcomes, especially for individuals residing in rural locations. However, it can also promulgate health disparities and inequities, hindering access to care for vulnerable patient populations such as those with a lower socioeconomic or literacy background. This dichotomy of effect requires a thorough examination to create solutions that eliminate inequities. The 2021 American College of Clinical Pharmacy Public and Professional Relations Committee has developed this white paper to examine the potential impact of remote delivery of clinical pharmacy services on health disparities and access to care and proposes solutions and calls to action for clinical pharmacists to address these areas.
An in vivo and in vitro model on the protective effect of corilagin on doxorubicin‐induced cardiotoxicity via regulation of apoptosis and PI3‐K/AKT signaling pathways
Authors: Ding Lianqin , Li Di , Li Ming , Zhao Dexia , Govindhan Annamalai , Santhoshkumar Mani , Xiang Hongli 
Published: October 2021

AbstractGlobally, doxorubicin (DOX)‐induced cardio dysfunction is a serious cause of morbidity and mortality in cancerous patients. An adverse event of cardiotoxicity is the main deem to restrict in the clinical application by oncologists. Corilagin (CN) is well known for its antioxidative, anti‐fibrosis, and anticancer effects. Herein, we aimed to evaluate the action of CN on DOX‐induced experimental animals and H9c2 cells. The myocardium‐specific marker, CK‐MB, and the influx of mitochondrial calcium levels were measured by using commercial kits. Biochemical indices reflecting oxidative stress and antioxidant attributes such as malondialdehyde, glutathione peroxidase, reduced glutathione, superoxide dismutase, and catalase were also analyzed in DOX‐induced cardiotoxic animals. In addition, mitochondrial ROS were measured by DCFH‐DA in H9c2 cells under fluorescence microscopy. DOX induction significantly increased oxidative stress levels and also modulated apoptosis/survival protein expressions in myocardial tissues. Western blots were used to measure the expressional levels of Bax/Bcl‐2, caspase‐3, PI3‐K/AKT, and PPARγ signaling pathways. Histological studies were executed to observe morphological changes in myocardial tissues. All of these DOX‐induced effects were attenuated by CN (100 mg/kg bw). These in vitro and in vivo results point towards the fact that CN might be a novel cardioprotective agent against DOX‐induced cardiotoxicity through modulating cardio apoptosis and oxidative stress.
Association between HIV PrEP indications and use in a national sexual network study of US men who have sex with men
Authors: Weiss Kevin M. , Prasad Pragati , Sanchez Travis , Goodreau Steven M. , Jenness Samuel M. 
Published: October 2021

AbstractIntroductionHIV pre‐exposure prophylaxis (PrEP) is effective in preventing HIV transmission. United States Public Health Service (USPHS) clinical practice guidelines define biobehavioral indications for initiation. To assess guideline implementation, it is critical to quantify PrEP nonusers who are indicated and PrEP users who are not indicated. We sought to estimate current PrEP use among US men who have sex with men (MSM), characterize whether their PrEP use aligned with their current indications for PrEP, and assess whether the association between PrEP indications and PrEP use differed by demography or geography.MethodsUsing data from a US web‐based sexual network study of MSM between 2017 and 2019, we measured PrEP usage and assessed whether respondents met indications for PrEP. Log‐binomial regression was used to estimate the relationship between PrEP indications and PrEP use, with adjustment for geography, age and race/ethnicity.ResultsOf 3508 sexually active, HIV‐negative MSM, 34% met indications for PrEP. The proportion with current PrEP use was 32% among MSM meeting indications and 11% among those without indications. Nearly 40% of those currently using PrEP did not meet indications for PrEP, and 68% of MSM with indications for PrEP were not currently using PrEP. After adjusting for geography and demographics, MSM with PrEP indications were about three times as likely to be currently using PrEP. This association varied slightly, but not significantly, by geographic region, age and race/ethnicity.ConclusionsIndications for PrEP strongly predicted current PrEP use among US MSM. However, we identified substantial misalignment between indications and use in both directions (indicated MSM who were not benefitting from PrEP, and MSM taking PrEP while not presently being indicated). PrEP underuse by those at greatest risk for HIV acquisition may limit the projected impact of PrEP implementation, despite reported increases in PrEP provision. This calls for further implementation efforts to improve PrEP delivery to those most in need during periods of elevated sexual risk and to close the gap between indications and uptake.
Ablation with zero‐fluoroscopy of premature ventricular complexes from aortic sinus cusps: A single‐center experience
Authors: Sánchez‐Millán Pablo J. , Gutiérrez‐Ballesteros Guillermo , Molina‐Lerma Manuel , Macías‐Ruiz Rosa , Jiménez‐Jáimez Juan , Tercedor Luis , Álvarez Miguel 
Published: October 2021

AbstractBackgroundCatheter ablation of premature ventricular complexes from aortic sinus cusps (ASC‐PVC) is a complex procedure that conventionally requires coronary catheterization (CC) to localize coronary artery ostium (CAO). Little published information is available on the mapping and ablation with zero‐fluoroscopy (ZF) of ASC‐PVC. The aim of the study was to determine the efficacy and safety of ASC‐PVC ablation with a ZF approach guided by 3D intracardiac echocardiography integration in the electroanatomical mapping system (ICE 3D‐EAM).MethodsThis observational study included one patient cohort treated conventionally and another treated with ICE 3D‐EAM‐guided ZF ablation. Clinical, efficacy, and safety outcomes were evaluated acutely and at 3 months follow‐up.ResultsThe study included 21 patients with ASC‐PVC: 10 in the ZF group (age 49 ± 16 years, 60% males) and 11 in the control group (age 47 ± 15 years, 27% males). Fluoroscopy was not required for any patient in the ZF group. Acute success was obtained in 80% of the ZF group vs 55% of the control group (P = .36). The recurrence rate was 30% in the ZF group vs 27% in the control group (P = 1). One nonsevere complication was observed in the ZF group (P = .48).ConclusionsZF catheter ablation of ASC‐PVC guided by ICE 3D‐EAM is feasible, effective, and safe.
The feasibility of electromagnetic sensing aided post pyloric feeding tube placement (CORTRAK) in patients with thrombocytopenia with or without anticoagulation on the intensive care unit
Authors: Stecher Stephanie Susanne , Barnikel Michaela , Drolle Heidrun , Pawlikowski Alexandra , Tischer Johanna , Weiglein Tobias , Alig Annabel , Anton Sofia , Stemmler Hans Joachim , Fraccaroli Alessia 
Published: October 2021

AbstractBackgroundThe successful initiation of enteral nutrition is frequently hampered by various complications occurring in patients treated in the intensive care unit (ICU). Successful placement of a nasojejunal tube by CORTRAK enteral access system (CEAS) has been reported to be a simple bedside tool for placing the postpyloric (PP) feeding tube.MethodsWe evaluated the efficacy and side effects using CEAS to establish EN in patients with critical illness, thrombocytopenia, and/or anticoagulation.ResultsFifty‐six mechanically ventilated patients were analyzed. Twenty‐four of them underwent prior hematopoietic stem cell transplantation (SCT). Sixteen patients received extracorporeal membrane oxygenation treatment because of acute respiratory distress syndrome. The median platelet count at PP placement was 26 g/L (range, 4–106 g/L); 16 patients received therapeutic anticoagulation (activated partial thromboplastin time, 50–70 s). CEAS‐assisted placement of a PP nasojejunal tube was performed successfully in all patients. The most frequent adverse event was epistaxis in 27 patients (48.2%), which was mostly mild (Common Terminology Criteria for Adverse Events grade 1, n = 21 [77.8%], and grade 2, n = 6). A significant association between a low platelet count and bleeding complications was observed (P < 0.001).ConclusionPerformed by an experienced operator, CEAS is a simple, rapidly available, and effective bedside tool for safely placing PP feeding tubes for EN in patients with thrombocytopenia, even when showing an otherwise‐caused coagulopathy in the ICU. Higher‐grade bleeding complications were not observed despite their obvious correlation to thrombocytopenia. A prospective study is in preparation.
Individual and combined effects of contact insecticides and high temperatures on Mediterranean flour moth,Ephestia kuehniellaZeller (Lepidoptera: Pyralidae)
Authors: Javanshir Mina , Karimzadeh Roghaiyeh , Hejazi Mir J , Shayestehmehr Hakimeh 
Published: October 2021

AbstractBACKGROUNDMediterranean flour moth or mill mothEphestia kuehniellaZeller (Lepidoptera: Pyralidae) is a common pest of cereals and flour throughout the world. In this study, eggs, third instar larvae, pupae and adults ofE. kuehniellawere exposed to five elevated temperatures at a range of 45 to 65 °C for 5, 8, 10, 14, 18, 23 and 30 min. The effect of cypermethrin and dichlorvos was assessed on third instar larvae. The larvae were exposed to the insecticides on glass and concrete arenas and their mortality was recorded 24 h after treatment. To determine combination effects, the third instar larvae were transferred into the Petri dishes treated with LC25(lethal concentration that kills 25%) of each insecticide and exposed to high temperatures for the period of time equal to LTi25values (time needed for killing 25% of tested insects).RESULTSExposing the eggs, third instar larvae and adults ofE. kuehniellato 55 °C for 30, 18 and 30 min respectively, resulted in 100% mortality. In the pupa, exposure to 65 °C caused 100% mortality after 23 min. Based on the LTe50values (temperature needed to cause 50% mortality in the tested population), pupa was the most tolerant life stage to the temperatures tested. The LC50values of cypermethrin and dichlorvos were 423.1 and 2608.5 mg active ingredient (a.i.) L−lon glass, and 2525.0 and 13502.8 mg a.i. L−lon concrete, respectively. The effect of cypermethrin was synergized by high temperatures.CONCLUSIONHigh temperatures, cypermethrin and dichlorvos were effective againstE. kuehniella. Exposure to combination of lower doses of cypermethrin and high temperatures at short time intervals may have potential in managing this pest. © 2021 Society of Chemical Industry.
Rapid high‐resolution melting method to identify human leukocyte antigen‐G (HLA‐G) 3′ untranslated region polymorphism +3142C/G (rs1063320)
Authors: Ben Salah Hamza , Jelassi Refka , Zidi Ines , Ben Amor Amor , Bizid Sondes , Ammi Radhia , Guizani Lamia , Bouratbine Aida , Aoun Karim , Chelbi Hanen 
Published: October 2021

AbstractBackgroundHLA‐G is a non‐classical class I gene of the human Major Histocompatibility encoding molecules with immune‐modulatory properties. Expression of HLA‐G is being largely studied in pathological conditions, such as tumors, viral infections, inflammation, and autoimmune diseases, grafted tissues, among others. HLA‐G +3142C/G (rs1063320: dbSNP database) polymorphism is located in 3′ UTR of HAL‐G and plays a key role in determining the magnitude of gene and protein expression. The detection of HLA‐G +3142C/G polymorphism in the most published report is done through polymerase chain reaction followed by enzymatic digestion. Therefore, it is so interesting to develop a rapid and sensitive assay to genotype HLA‐G +3142C/G polymorphism. High‐resolution melt analysis (HRM) is a technology that is based on the analysis of the melting profile of PCR products through gradual temperature increase. The aim of this work is to apply high‐resolution melt method for genotyping the HLA‐G +3142C/G polymorphism.MethodsDNA from 118 individuals was extracted from whole blood with QIAamp® DNA blood mini kit (Qiagen, Germany). Primer couple was designed using Primer 3 online tools so as to have only one SNP in the target sequence for high HRM efficiency. Positive Controls were identified using DNA sequencing and used as reference when assigning genotypes for trial samples.ResultsWe were able to recognize the three genotypes with similar accuracy than DNA sequencing using high resolution melting method. Hardy‐Weinberg equilibrium test shows that our population is in equilibrium for the studied SNP. Genotypes frequencies of +3142C/G polymorphism in Tunisian general population are 0.475 for heterozygote G/C, 0.186 for homozygote G/G and 0.339 for homozygote C/C.ConclusionHRM is a cost‐effective method suitable for SNP genotyping.
Low‐power dual‐band voltage‐controlled oscillator using a fourth‐order resonant technique
Authors: Chang Yu‐Hsin , He Sih‐Sian 
Published: October 2021

AbstractA low‐power dual‐band voltage‐controlled oscillator (VCO) using a fourth‐order resonant technique implemented in 0.18‐μm CMOS process is presented in this letter. By utilizing a fourth‐order LC‐type resonant network and a current‐reused technique, the proposed VCO operates in the dual‐band mode and improves the overall performance. The tuning ranges of band 1 and band 2 are from 3.39 to 3.68 GHz and from 7.2 to 7.57 GHz controlled by a controlled‐voltage VC, respectively. The measured phase noises at 1 MHz frequency offset are −117.39 dBc/Hz and −113.58 dBc/Hz for output frequencies of 3.68 and 7.21 GHz, respectively. Besides, the figures‐of‐merit (FOM) at 3.68 and 7.21 GHz output frequencies are −182.5 and −184.5 dBc/Hz, respectively. The proposed VCO core consumes 4.2 mW from a 1.2‐V supply.
Nusinersen by subcutaneous intrathecal catheter for symptomatic spinal muscular atrophy patients with complex spine anatomy
Authors: Carson Vincent J. , Young Millie , Brigatti Karlla W. , Robinson Donna L. , Reed Robert M. , Sohn Jihee , Petrillo Marco , Farwell Wildon , Miller Freeman , Strauss Kevin A. 
Published: October 2021

AbstractIntroduction/AimsIntrathecal administration of nusinersen is challenging in patients with spinal muscular atrophy (SMA) who have spine deformities or fusions. We prospectively studied the safety and efficacy of nusinersen administration via an indwelling subcutaneous intrathecal catheter (SIC) for SMA patients with advanced disease.MethodsSeventeen participants commenced nusinersen therapy between 2.7 and 31.5 years of age and received 9 to 12 doses via SIC. Safety was assessed in all participants. A separate efficacy analysis comprised 11 nonambulatory, treatment‐naive SMA patients (18.1 ± 6.8 years) with three SMN2 copies and complex spine anatomy.ResultsIn the safety analysis, 14 treatment‐related adverse events (AEs) occurred among 12 (71%) participants; all were related to the SIC and not nusinersen. Device‐related AEs interfered with 2.5% of nusinersen doses. Four SICs (24%) required surgical revision due to mechanical malfunction with or without cerebrospinal fluid leak (n = 2), and one (6%) was removed due to Staphylococcus epidermidis meningitis. In the efficacy analysis, mean performance on the nine‐hole peg test improved in dominant (15.9%, P = 0.012) and nondominant (19.0%, P = 0.008) hands and grip strength increased by 44.9% (P = 0.031). We observed no significant changes in motor scales, muscle force, pulmonary function, or SMA biomarkers. All participants in the efficacy cohort reported one or more subjective improvement(s) in endurance, purposeful hand use, arm strength, head control, and/or speech.DiscussionFor SMA patients with complex spine anatomy, the SIC allows for reliable outpatient administration of nusinersen that results in meaningful improvements in upper limb function, but introduces risks of technical malfunction and iatrogenic infection.
Palliative care is not associated with decreased intensity of care: Results of a chart review from a large children's hospital
Authors: Sedig Laura K. , Spruit Jessica L. , Southwell Jessica , Paul Trisha K. , Cousino Melissa K. , McCaffery Harlan , Pituch Kenneth , Hutchinson Raymond 
Published: October 2021

AbstractBackgroundPalliative care is an important component of pediatric oncology care, especially for children who will not be cured of their disease. However, barriers remain to integration of this service. One barrier is the perception that it indicates “giving up.” This study examined if palliative care involvement was associated with a decreased intensity of care at the end of life for children with malignancy at a large academic center with a well‐established palliative care program.ProcedureThis is a retrospective chart review that measured intensity of care as the number of emergency department visits, hospital days, and intensive care unit days in the last one and three months of life. The data were compared for patients with and without palliative care involvement and with and without hospice involvement.ResultsPalliative involvement was not associated with a decrease in the intensity of care in the last three months of life. Hospice care was associated with a decreased intensity of care. These results held true in analyses adjusted for age at death, gender, and type of malignancy.ConclusionsThese data can reassure patients, families, and providers that palliative involvement does not necessitate decreased intensity of care. Patients and families often choose hospice care to decrease the amount of time spent at the hospital and it was associated with meeting that goal.
Registration of aphid‐resistant ‘California Blackeye 77’ cowpea
Authors: Huynh Bao‐Lam , Duong Tra , Clark Nicholas E. , Long Rachael , Light Sarah E. , Dahlquist‐Willard Ruth M. , Ehlers Jeffrey D. , Close Timothy J. , Roberts Philip A. 
Published: October 2021

Abstract‘California Blackeye 77’ (CB77) (Reg. no. CV‐344, PI 698656) is a blackeye‐type cowpea [Vigna unguiculata (L.) Walp] cultivar developed by the University of California, Riverside. CB77 is distinguished from the industry standard cultivars, ‘California Blackeye 46’ (CB46) and ‘California Blackeye 5’ (CB5), by its ability to resist infestation caused by cowpea aphid (Aphis craccivora Koch), a destructive sap‐sucking insect pest prevalent in the Central Valley of California and warm‐to‐hot regions worldwide. CB77 was developed by introgression of two known quantitative trait loci for aphid resistance from the African cowpea breeding line IT97K‐556‐6 into CB46 through marker‐assisted backcrossing. Genotyping with 51,128 single nucleotide polymorphism markers reveals that CB77 is near‐isogenic to CB46 and carries two resistance haplotypes (∼4 Mb in total) from IT97K‐556‐6. On‐station and on‐farm trials with aphid infestations confirmed the inherent resistance in CB77 (aphids covered 0–10% of plant surface area without causing any crown damage, whereas check CB46 had aphids covering 60–70% of plant surface area and causing severe crown damage). Under protected conditions, CB77 showed grain yield, seed quality, and other agronomic characteristics equivalent to CB46 and better yield than CB5. CB77 could therefore be substituted for CB46 and CB5 in production regions where aphids are present. The near‐isogenic pair CB77 and CB46 are also useful materials for resistance gene discovery.
Patient reported factors influencing the decision‐making process of men with localised prostate cancer when considering Active Surveillance—A systematic review and thematic synthesis
Authors: Cunningham Maggie , Murphy Mike , Sweeney Paul , Richards Helen L. 
Published: October 2021

AbstractObjectivesOutcomes for men with localised prostate cancer managed with Active Surveillance (AS) are similar to outcomes for men who have received Active Treatment. This review explore men's perceptions of the factors that influence their decision‐making process when considering AS.MethodA systematic review of studies was conducted up to May 2021, including qualitative studies which explored the decision making of men with localised prostate cancer when considering AS. Evidence was analysed using thematic synthesis.ResultsThirteen papers, including 426 men, met inclusion criteria and were analysed in the review. Approximately half of the men had chosen AS and half had chosen Active Treatment. The choice of AS was not a one‐off decision but rather an ongoing behaviour. Four themes were identified and considered within a temporal model: pre‐diagnosis representations of cancer and treatment; experience of testing and diagnosis; patient decision making; and emotional adjustment to AS. Key barriers and facilitators to men choosing AS were identified. In deciding whether or not to choose AS, men balanced a desire for quality of life against fear of cancer progression.ConclusionsBoth cognitive representations and emotional arousal influence how men decided whether or not to opt for AS. Interventions tailored to elicit and address emotional appraisals of risk, and increase trust in AS protocols, may be of value in helping men to make decisions around treatment for localised prostate cancer.
A case of prominent immunoglobulin G4‐positive lymphadenopathy in response to microscopic lung cancer
Authors: Yuzawa Motoi , Ohta Hiromitsu , Nomura Motoko , Minegishi Kentaro , Oshiro Hisashi , Yamaguchi Yasuhiro 
Published: October 2021

AbstractImmunoglobulin G4 (IgG4)‐related disease is established as a new clinical entity, characterized by high levels of plasma IgG4 and IgG4‐positive plasma cell infiltration. However, the elevation of plasma IgG4 and infiltration of IgG4‐positive cells have been observed in other diseases, including malignancy. We experienced a case of prominent IgG4‐positive lymphadenopathy, which was diagnosed as a reactive lesion in response to lung cancer. The cancerous lesion was so small in size that it was difficult to reveal the coexisting lung cancer. Surgical lymph node biopsy and endobronchial ultrasound‐guided transbronchial needle aspiration did not reveal lymph node metastasis of cancer. Mediastinal lymph node dissection finally revealed it. After the right upper lobectomy, the patient underwent postoperative chemotherapy and remains cancer‐free after 1 year. Our case suggests that close examination and careful follow‐up are necessary when IgG4‐positive lymphadenopathy is observed.
A case of diffuse aspiration bronchiolitis due to oesophageal stenosis after radiation therapy
Authors: Horimoto Kazuhide , Kai Yoshiro , Fukuoka Atsuhiko , Tamaki Shinji , Yoshikawa Masanori , Hamada Kaoru , Muro Shigeo 
Published: October 2021

AbstractA 66‐year‐old woman was hospitalized for recurrent pneumonia twice in 1 year. After treatment for pneumonia, chronic coughing, sputum and low‐grade fever continued, so she was referred and admitted to our hospital for investigation. Chest computed tomography revealed a lung infiltrative shadow and diffuse centrilobular micronodules. Histological findings from transbronchial lung biopsy showed chronic inflammation and giant cells in the bronchiole. These findings were compatible with diffuse aspiration bronchiolitis (DAB), which is characterized by chronic inflammation of the bronchioles caused by recurrent aspiration of foreign bodies. Oesophagogastroduodenoscopy revealed stenosis of the oesophageal entrance, which was thought to be caused by radiation therapy for hypopharyngeal cancer 20 years before. Antibiotic treatment ameliorated the centrilobular nodule shadow. After discharge, there was no recurrence. This is the first case report of DAB resulting from oesophageal stenosis associated with hypopharyngeal cancer and will serve as an educational case.