bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthopaedic Application of Cryotherapy
Authors: Kunkle Bryce F. , Kothandaraman Venkatraman , Goodloe Jonathan B. , Curry Emily J. , Friedman Richard J. , Li Xinning , Eichinger Josef K. 
Published: January 2021

» Cold therapy, also known as cryotherapy, includes the use of bagged ice, ice packs, compressive cryotherapy devices, or whole-body cryotherapy chambers. Cryotherapy is commonly used in postoperative care for both arthroscopic and open orthopaedic procedures.» Cryotherapy is associated with an analgesic effect caused by microvasculature alterations that decrease the production of inflammatory mediators, decrease local edema, disrupt the overall inflammatory response, and reduce nerve conduction velocity.» Postoperative cryotherapy using bagged ice, ice packs, or continuous cryotherapy devices reduced visual analog scale pain scores and analgesic consumption in approximately half of research studies in which these outcomes were compared with no cryotherapy (11 [44%] of 25 studies on pain and 11 [48%] of 23 studies on opioids). However, an effect was less frequently reported for increasing range of motion (3 [19%] of 16) or decreasing swelling (2 [22%] of 9).» Continuous cryotherapy devices demonstrated the best outcome in orthopaedic patients after knee arthroscopy procedures, compared with all other procedures and body locations, in terms of showing a significant reduction in pain, swelling, and analgesic consumption and increase in range of motion, compared with bagged ice or ice packs.» There is no consensus as to whether the use of continuous cryotherapy devices leads to superior outcomes when compared with treatment with bagged ice or ice packs. However, complications from cryotherapy, including skin irritation, frostbite, perniosis, and peripheral nerve injuries, can be avoided through patient education and reducing the duration of application.» Future Level-I or II studies are needed to compare both the clinical and cost benefits of continuous cryotherapy devices to bagged ice or ice pack treatment before continuous cryotherapy devices can be recommended as a standard of care in orthopaedic surgery following injury or surgery.
Teasing Meaning Out of a Tangle of Fracturing Data
Authors: Rassenfoss Stephen 
Published: January 2021

The snarled red lines on the chart look more like a plate of spaghetti than a source of fracturing insights.
It looks like a meaningless mess, which is generally how the ups and downs of difficult stages are viewed.
To Adam Hoffman, a completion engineer for Chesapeake Energy, those 47-stages-worth of data look like a valuable opportunity.
“We see so many stages with so many odd spikes and drops or chatter. We chop it off and say that was an odd stage. In my mind when we are looking at all those stages, we should wonder, ‘what was that pressure spike telling us,’” he said.
That curiosity became a research project after Chesapeake encountered a spate of blockages in recently fractured Eagle Ford wells. The investigation into the cause of the casing damage led to a collaboration with Well Data Labs to look for connections between pressure changes and what is happening in the wells.
Based on hundreds of stages of data from 19 wells fractured in the Eagle Ford, and later in the Powder River Basin, they reported finding a distinctive pressure signature that provides a reliable, but not foolproof, guide to when casing damage is likely.
Well Data Labs has automated the search for those signatures as it looks for the meaning of the terabytes of fracturing data in this overwhelming number of seemingly random, squiggly lines.
The oilfield data and software company is working on ways to monitor changes in the fracturing-fluid chemistry, the proppant intake into perforations, and an explanation for the pressure spikes seen before the pressure falls, said Jessica Iriarte, research manager at Well Data Labs.
The troubleshooting and pressure analysis were covered in paper SPE 201484 presented at the 2020 SPE Annual Technical Conference and Exhibition (ATCE).
It described how engineering trouble-shooting revealed that geological stresses were the likely source of problems in one case, and faulty pipe in the other. It followed up with data analysis, which used machine learning to identify distinctive patterns that provide an early warning of what is happening in the well faster and more objectively than a completion engineer studying the chart.
Based on the troubleshooting, Chesapeake made changes that largely eliminated those costly problems.
But it was also a costly learning process. In the Eagle Ford, they identified the underlying problem by investigating why multiple coiled-tubing runs were blocked while they were trying to drill out plugs after fracturing. When that happens, Hoffman said, “it can mean a week lost working past it.”
Failure to drill out a plug can block access to the productive rock further down the lateral.
A reliable automated treating-pressure analysis in the daily report could alert the completion team to problems while fracturing is in progress. They could then make adjustments on later stages and create a plan to limit the time lost when drilling out plugs on stages where they are likely to encounter tight sections.
Against the Grain: Three Proppant Delivery Approaches That Buck the Status Quo
Authors: Jacobs Trent 
Published: January 2021

Pumping proppant down a wellbore is the easy part.
Ensuring that the precious material does its job is another matter.
A trio of field studies recently presented at the 2020 SPE Annual Technical Conference and Exhibition (ATCE) highlight in different ways how emerging technology and old-fashioned problem solving are moving the industry needle on proppant and conductivity control.
These examples include the adoption of unconventional completion techniques in a conventional oil field in Russia and work to validate the use of small amounts of ceramic proppant in North Dakota’s tight-oil formations. Both studies seek to counter widely held assumptions about proppant conductivity.
A third study details a recently developed chemical coating that Permian Basin producers are applying “on the fly” to sand before it is pumped downhole. The new adhesive material has found a niche in helping operators mitigate the amount of sand that returns to surface during flowback, a sectorwide issue that drives up completion costs and later may spell trouble for artificial lift systems.
Disproving “The Overflush Paradigm”
After conventional reservoirs are hydraulically fractured, both from vertical and horizontal wells, it has been standard practice for decades to treat the newly propped perforations with a gentle touch.
The approach to this end is known as underflushing.
When underflushing, the goal is to leave behind just a few barrels’ worth of proppant-laden slurry over the perforations before attempting to complete further stages. The motivation for this boils down to the need for an insurance policy against displacing the near-wellbore proppant pack and causing the open fracture face to pinch off before it ever has a chance to transmit hydrocarbons.
Such carefulness comes at a price. Underflushing raises the risk of needing a cleanout before oil can flow optimally to surface. This not only delays the arrival of first oil, it means extra equipment and personnel are required.
However, a more glaring downside to underflushing is that it appears to be an unnecessary precaution. The near-wellbore fracture area is, in fact, more robust than what conventional wisdom allows credit for.
Technology Focus: Digital Data Acquisition (January 2021)
Authors: Sarma Pallav 
Published: January 2021

COVID-19 has significantly accelerated the adoption of digital technologies across all industries, and the oil and gas industry has been no exception. Consequently, interest in digital data acquisition, the backbone of all digital transformation work flows, also has increased significantly. This can clearly be seen in the multifold increase in the number of SPE papers on this topic since last year.
This feature will continue to focus on technologies to improve data accessibility and data acquisition, as well as entirely new data sources and their applications.
The papers chosen this year include real-time remote monitoring of steam traps and corrosion using wireless sensors, enabling faster and easier access to relevant subsurface information through deep learning of unstructured documents, and automation of real-time drilling work flows through digital transformation technologies.
While not reflected in these papers, a related emerging technology that has the potential to transform the data acquisition paradigm and that is garnering much attention, however, is edge computing. As the saying goes, if you cannot bring the data to the model, take the model to the data.
One of the main difficulties in faster adoption of digital transformation in oil and gas has been access to reliable real-time data that can be converted to real-time decisions. This is the case because of the remote and geographically distributed nature of most oil and gas assets and legacy outdated and piecemeal information-technology (IT) infrastructures, making it difficult to provide models with reliable, standardized data in a timely manner.
Edge-computing frameworks eliminate scale and capacity constraints and bypass limitations of current IT infrastructures, truly enabling operationalization of models for real-time decision making. Edge computing, together with machine learning and artificial intelligence, will be the real enablers of digital transformation.
Pulse Radar Randomly Interrupted Transmitting and Receiving Optimization Based on Genetic Algorithm in Radio Frequency Simulation
Authors: LIU Xiaobin , Zhao Feng , Ai Xiaofeng , Wu Qihua 
Published: January 2021

Abstract
The interrupted transmitting and receiving (ITR) can be used in anechoic chamber to solve the coupling between the transmitted and reflected signals. When the ITR periods are random, the fake peaks in high resolution range profile (HRRP) of ITR echo can be reduced. Then, by utilizing the piecewise sparse property of ITR echo, the HRRP is reconstructed based on compressive sensing (CS). However, the periods of ITR determine the restricted isometry property (RIP) condition and the HRRP reconstruction performance. In order to improve the HRRP reconstruction performance, the ITR periods sequence optimization method based on genetic algorithm (GA) is proposed in this paper. The correlation coefficient of the sensing matrix columns is minimized after optimization so that the RIP of sensing matrix can be well satisfied. Simulation and comparison results illustrate that the optimization method converges fast and the HRRP reconstruction performance is improved with the optimized ITR periods.
Numerical modeling of the disappearance of equatorial plasma bubble by nighttime medium-scale traveling ionospheric disturbances
Authors: Chou Min-Yang , Lin Charles C. H. , Huba Joseph D. 
Published: January 2021

Abstract
The Naval Research Laboratory first-principles ionosphere model SAMI3/ESF is performed to study the interaction between the nighttime medium-scale traveling ionospheric disturbances (MSTIDs) and equatorial plasma bubbles (EPBs). The synthetic dynamo currents are imposed into the potential equation to induce polarization electric fields for generating the MSTIDs. Simulations demonstrate that the MSTIDs can inhibit the upward growth of EPBs; however, MSTIDs alone are insufficient to explain the disappearance of EPBs. We found that the meridional winds likely contribute to the disappearance of MSTIDs by reducing the background electron density and polarization electric fields within the EPBs. Then, the MSTIDs transport plasma to fill the EPB depletions up via E × B drifts. Both MSTIDs and meridional winds are necessary to comprehend the underlying mechanism of EPB disappearance. We also found that the zonal and vertical E × B drifts within the MSTIDs affect the morphology of EPBs, leading to a reverse-C shape structure.
Clearance of inflammatory cytokines in Patients with Septic Acute Kidney Injury During Renal Replacement Therapy Using the EMiC2 Filter (Clic-AKI study)
Authors: Lumlertgul Nuttha , Hall Anna , Camporota Luigi , Crichton Siobhan , Ostermann Marlies 
Published: January 2021

Abstract
Background: The EMiC2 membrane is a medium cutoff hemofilter (45 kiloDalton). Little is known regarding its efficacy in eliminating medium-sized cytokines in sepsis. This study aimed to explore the effects of continuous veno-venous hemodialysis (CVVHD) using the EMiC2 filter on cytokine clearance.Methods: This was a prospective observational study conducted in critically ill patients with sepsis and acute kidney injury requiring kidney replacement therapy. We measured concentrations of 12 cytokines [Interleukin (IL) IL-1β, IL-1α, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-ƴ, tumor necrosis factor (TNF)-α, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, epidermal growth factor (EGF)] in plasma at baseline (T0) and pre- and post-dialyzer at 1, 6, 24, and 48 hours after CVVHD initiation and in the effluent fluid at corresponding time points. Outcomes were the effluent and adsorptive clearance rates, mass balances, and changes in serial serum concentrations.Results: Twelve patients were included in the final analysis. All cytokines except EGF concentrations declined over 48 hours (p<0.001). The effluent clearance rates were variable and ranged from negligible values for IL-2, IFN-ƴ, IL-1α, IL-1β, and EGF, to 19.0 ml/min for TNF-α. Negative or minimal adsorption was observed. The effluent and adsorptive clearance rates remained steady over time. The percentage of cytokine removal was low for most cytokines throughout the 48-hour period. Conclusion: EMiC2-CVVHD achieved modest removal of most cytokines and demonstrated small to no adsorptive capacity despite a decline in plasma cytokine concentrations. This suggests that changes in plasma cytokine concentrations may not be solely influenced by extracorporeal removal.
Association of Menopausal Status with COVID-19 outcomes: a Propensity Score-Matching Analysis
Authors: Wang Xing-Wang , Hu Hao , Xu Zhi-Yong , Zhang Gong-Kai , Yu Qing-Hua , Yang Hui-Lan , Zheng Ji-Hua 
Published: January 2021

Abstract
Background: Despite the growing number of studies on the Coronavirus Disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes.Materials and methods: In this retrospective study, we included 336 COVID-19 in-patients between February 15, 2020 and April 30, 2020 at the Taikang Tongji Hospital (Wuhan), China. Electronic medical records, including patient demographics, laboratory results, and chest computed tomography (CT) images were reviewed.Results: In total, 300 patients with complete clinical outcomes were included for analysis. The mean age was 65.3 years and most patients were women (n=167, 55.7%). Over 50% of patients presented with comorbidities, with hypertension (63.5%) being the most common comorbidity. After propensity-score matching, results showed that men had significantly higher odds than premenopausal women for developing severe disease type (23.7% vs. 0%, OR 17.12, 95% CI 1.00–293.60; p=0.003) and bilateral lung infiltration (86.1% vs. 64.7%, OR 3.39, 95% CI 1.08–10.64; p= 0.04), but not for mortality (2.0% vs. 0%, OR 0.88, 95% CI 0.04–19.12, p=1.00). However, non-significant difference was observed among men and post-menopause women in the percentage of severe disease type (32.7% vs. 41.7%, OR 0.68, 95% CI 0.37–1.24, p=0.21) and bilateral lung infiltration (86.1% vs. 91.7%, OR 0.56, 95% CI 0.22–1.47, p=0.24), mortality (2.0% vs. 6.0%, OR 0.32, 95% CI 0.06–1.69, p=0.25).Conclusions: Men had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor-prognosis of postmenopausal women in clinical practice.
Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data
Authors: Cheng Jianhua , Nie Ding , Li Bin , Gui SongBai , Li ChuZhong , Zhang YaZhuo , Cavallo Luigi Maria , Zhao Peng 
Published: January 2021

Abstract
Background: Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we reviewed a series of cases of pituicytomas. The diagnosis and treatment of pituicytoma must be further elucidated.Methods: Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected. The clinical features, including radiological and histological examination, surgical records and prognosis were reviewed. Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results.Results: Our cohort included 4 males (36.37%) and 7 females (63.63%), with a mean age of 48.6 years. The tumor was located in the suprasellar region in 4 patients (36.37%), intrasellar region in 5 patients (45.45%), and intrasellar-suprasellar region in 2 patients (18.18%). All patients were misdiagnosed with other common tumors in the sellar region before the operation. During the operation, gross total resection of the tumor was achieved in 6 patients (54.55%), and subtotal resection was achieved in 5 patients (45.45%). The mean progression-free survival time was 33.72 months. Tumor progression after surgical resection occurred in 4 patients (36.37%). Among them, 72.73% of the patients with subtotal resection experienced progression, while 18.18% of the patients with gross total resection experienced progression. Combined with the 68 cases in the literature, gross total resection was an independent risk factor for progression-free survival time (P<0.05).Conclusion: Pituicytomas are more common in middle-aged people and in the sellar region. The clinical manifestations of pituicytomas are different, but no diagnostic clinical features have been identified other than an abnormally abundant blood supply. Currently, gross total resection is the best approach for the treatment of pituicytomas. More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.
Alternative Splicing Signature in human Crohn’s Disease
Authors: Li Daowei , Tan Yue 
Published: January 2021

Abstract
Although hundreds of risk loci for Crohn’s disease (CD) have been identified, the underlying pathogenesis of CD remains unclear. Recently, evidence has shown that aberrant gene expression in CD patients’ colon tissues was associated with progression of CD. We reasoned that post-transcriptional regulation, especially alternative splicing (AS), may also play important roles in the pathogenesis of CD. Herein we re-analyzed a public mRNA-seq data from NCBI GEO dataset (GSE66207), and identified approximately 3,000 unique AS events in CD patients compared to the healthy controls. “Lysine degradation” and “Sphingolipid metabolism” are the top two AS events enriched terms in CD patients. In a validation study, we also sequenced 8 subjects and demonstrated that key genes which were previously linked to CDs, such as IRF1, STAT3, also had significant AS events in CDs. In conclusion, our study provided a landscape of AS events in CD, especially as the first study focused on a Chinese cohort. Our data suggested that dysregulation of AS may be a new mechanism that contribute to the pathogenesis of CD.
Energy delivery guided by indirect calorimetry in critically ill patients: a systematic review and meta-analysis
Authors: Duan Jing-Yi , Zheng Wen-He , Zhou Hua , Xu Yuan , Huang Hui-bin 
Published: January 2021

Abstract
Background: The use of indirect calorimetry (IC) is increasing due to its precision in resting energy expenditure (REE) measurement in critically ill patients. Thus, we aimed to evaluate the clinical outcomes of an IC-guided nutrition therapy compared to predictive equations strategy in such a patient population.Methods: We searched PubMed, EMBASE, and Cochrane library databases up to Oct 25, 2020. Randomized controlled trials (RCTs) were included if they focused on energy delivery guided by either IC or predictive equations in critically ill adults. We used the Cochrane risk-of-bias tool to assess the quality of the included studies. Short-term mortality was the primary outcome. The meta-analysis was performed with the fixed-effect model or random-effect model according to the heterogeneity. Results: Eight RCTs with 991 adults met the inclusion criteria. The overall quality of the included studies was moderate. Significantly higher mean energy delivered per day was observed in the IC group, as well as percent delivered energy over REE targets, than the control group. IC-guided energy delivery significantly reduced short-term mortality compared with the control group (risk ratio=0.77; 95% CI, 0.60 to 0.98; I2=3%, P=0.03). IC-guided strategy did not significantly prolong the duration of mechanical ventilation (mean difference [MD]=0.61 days; 95% CI, -1.08 to 2.29; P=0.48), length of stay in ICU (MD=0.32 days; 95% CI, -2.51 to 3.16; P=0.82) and hospital (MD=0.30 days; 95% CI, -3.23 to 3.83; P=0.87). Additionally, adverse events were similar between the two groups. Conclusions: This meta-analysis indicates that IC-guided energy delivery significantly reduces short-term mortality in critically ill patients. This finding encourages the use of IC-guided energy delivery during critical nutrition support. But more high-quality studies are still needed to confirm these findings.
A placental trisomy 2 detected by NIPT evolved in a fetal small Supernumerary Marker Chromosome (sSMC).
Authors: Domaradzka Justyna Anna , Deperas Marta , Obersztyn Ewa , Kucińska-Chahwan Anna , Brison Nathalie , Bogaert Kris Van Den , Roszkowski Tomasz , Kędzior Marta , Bartnik-Głaska Magdalena , Łuszczek Alicja , Jakubów-Durska Krystyna , Vermeesch Joris Robert , Nowakowska Beata Anna 
Published: January 2021

Abstract
Background: Non-invasive prenatal testing (NIPT) is a rapidly developing and widely used method in the prenatal screening. Recently, the widespread use of the NIPT caused a neglecting of the limitations of this technology. Case presentation: The 38-year-old woman underwent amniocentesis because of a high risk of trisomy 2 revealed by the genome-wide Non-Invasive Prenatal Test (NIPT). The invasive prenatal diagnosis revealed the mosaicism for a small supernumerary marker chromosome sSMC derived from chromosome 2. Interphase fluorescence in situ hybridization (FISH) on uncultured amniocytes revealed three signals of centromere 2 in 30% of the cells. GTG-banded metaphases revealed abnormal karyotype (47,XX,+mar[21]/46,XX[19]) and was confirmed by array comparative genomic hybridization (aCGH). Cytogenetic analyses (FISH, aCGH, karyotype) on fetal skin biopsies were performed and confirmed the genomic gain of the centromeric region of chromosome 2. In the placenta, three cell lines were detected: a normal cell line, a cell line with trisomy 2 and a third one with only the sSMC.Conclusion: Whole-genome Non-Invasive Prenatal Testing allows not only the identification of common fetal trisomies but also diagnosis of rare chromosomal abnormalities. Especially in such cases, it is extremely important to perform not only NIPT verification on a sample of material other than trophoblast, but also to apply appropriate research methods. Such conduct allows detailed analysis of the detected aberration, thus appropriate clinical validity.