bluuebunny/crossref_metadata_2025_split huggingface dataset:
«SILENT ALL THESE YEARS» OR BECOMING IN EVERYDAYNESS: TORI AMOS AND HER POETICS OF THE QUOTIDIAN
Authors: Matasova Iuliana 
Published: December 2021

Created by the American singer-songwriter Tori Amos «Silent All These Years» is a prominent cultural product of the 1990s in the domain of western popular music. Released in the beginning of the decade it has actualized the current sensibilities, ethically and aesthetically. Deploying the efficient mutual engagement of feminist and postmodernist strategies the author mobilizes the quotidian and performs its intellectual aestheticization.
The study focuses on the ways the everyday operates in the song lyrically and musically, as well as on the author’s intention of aestheticizing the mundane. There is an important interdependence between the material circumstances in which the song was created and its genre form of an indie ballad — an ironic gesture that subverts the «heroic» becomes definitive of the piece. The embodied «women’s» experience of the mundane comes as grotesque, «women’s» time threatens to devour the time of «progress», elements of western eschatological mythology undergo domestication and the archetypal image of the Mermaid receives a re-reading, urban everyday vocabulary ruptures the «high» register. An intensification of sameness, repetition and monotony, however, accentuates a non-ironic potentiality of emancipation and insight.
The poetics of the quotidian in Amos, thus, presents itself politically by locating the invisibly heroic becoming in everydayness as opposed to a one-time extraordinary action. One of the singular possibilities of such a becoming is a possibility of a continuing, and always risky, dialogic exchange.
Can Lactobacillus spp. Be a Factor Reducing the Risk of Miscarriage?
Authors: KIECKA ANETA , MACURA BARBARA , SZCZEPANIK MARIAN 
Published: December 2021

Abstract
Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and endocrine factors, uterine malformations, improper embryo selection, and lifestyle. Perhaps a hitherto underappreciated cause of miscarriage may be an abnormal microbiota composition of the female reproductive system. Lactobacillus spp. is the most common bacteria within the reproductive tract. However, the protective role of Lactobacilli in the vagina has been well described in the literature, while it is still unknown what function Lactobacilli may have in the uterus. Moreover, new research shows that Lactobacillus spp. can have a role in miscarriage. However, both molecular and immunological mechanisms of host-Lactobacillus spp. interactions are not fully understood. Understanding these relationships will help address the importance and extent of the protective role of Lactobacillus spp. in miscarriage.
A comparative study of oral Ketoconazole versus Itraconazole in the treatment of Tinea versicolor
Authors: Begum Sharmin , Karim Md Nazmul , Haque AKM Rejaul , Rahman Rahat Mohammad Lutfur 
Published: December 2021

Tinea (pityriasis) versicolor is a superficial fungal infection and one of the most commonly found pigmentary disorders of the skin caused by the yeast Malassezia. Multiple topical as well as systemic therapies are available for treatment. Systemic therapies are used for extensive disease, frequent relapse or where topical agents have failed. The aim that translates the rationale of the study was to compare the efficacy, safety, tolerability and cost effectiveness of oral ketoconazole dose 200mg daily for 7 days versus a single dose of 400 mg of itraconazole in the treatment of tinea versicolor. A total of 64 patients (aged 18-50 years) were selected for the study from the period of June 2019 to November 2019 in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Bangladesh. Cases having extensive involvement were diagnosed clinically and confirmed by wood's lamp and KOH microscopy was taken. Patients were randomly allocated into equal groups. Group A was given oral ketoconazole dose 200mg daily for 7 days and Group B has given a single dose of 400 mg of itraconazole. 47 (73.4%) male and 17(26.6%) female were included in the study. The mean age of group A was 29.2(SD±8.6) and in group B 28.2(SD±8.5) years. The mean duration of the disease in group A was 3.9(±2.7) months and 3.5(±2.2) months in group B. In group A clinical responders was found cure 25(78.1%), improvement 5(15.6%) and failure in 2(6.2%) and in group B it was found cure 22(68.8%), improvement 7(21.87%) and failure 3(9.4%) at one month. At two months in the group A clinical responder was found to cure 22(68.8%), improvement 5(15.6%), failure in 3(9.4%) and relapse 2(6.2%). In group B it was found cure 18(56.2%), improvement 6(18.75%), failure 4(12.5%) and relapse 4(12.5%). Both oral ketoconazole dose 200mg daily for 7 days versus single dose 400 mg of itraconazole can be effective in the treatment of tinea versicolor with extensive involvement.
CBMJ 2020 July: Vol. 09 No. 02 P: 26-33
PENGARUH FUNGSI-FUNGSI MANAJEMEN TERHADAP KINERJA APARATUR SIPIL NEGARA PADA KANTOR KECAMATAN MOLAWE KABUPATEN KONAWE UTARA
Authors: Sappodin Sappodin , Zaid Sudirman , Sinarwaty Sinarwaty , Rommy Nursaban , Hartini Hartini , Hasan Rachmad Rialdy 
Published: December 2021

This study aimed to determine the Influence of planning, organizing, actuating and controlling toward the performance of the State Civil Apparatus at the Molawe District Office, Konawe Utara Regency simultaneously and partially. The sample in this study as many 35 people Apparatus State Civil who worked at the Molawe District Office, Konawe Utara Regency. Analysis tool used is quantitative analysis using Multiple Linear Regression Analysis.The results showed that the simultaneous functions of planning, organizing, actuating and controlling had significant effect on the performance of the State Civil Apparatus at the Molawe District Office, Konawe Utara Regency. And partial functions of planning, organizing and actuating had positif significant effect on the performance of the State Civil Apparatus at the Molawe District Office, Konawe Utara Regency, so that the hypothesis can be accepted.
Long Non-Coding RNA LINC01572 Promotes Hepatocellular Carcinoma Progression via Sponging miR-195-5p to Enhance PFKFB4-Mediated Glycolysis and PI3K/AKT Activation
Authors: Lai Shihui , Quan Zhipeng , Hao Yuesong , Liu Jun , Wang Zhiqian , Dai Luo , Dai Hongliang , He Songqing , Tang Bo 
Published: December 2021

Background: Accumulating evidence indicates that type 2 diabetes mellitus (T2DM) is a risk factor for hepatocellular carcinoma (HCC), and T2DM-associated HCC represents a common type of HCC cases. We herein identify an lncRNA LINC01572 that was aberrantly upregulated in T2DM-related HCC via high-throughput screening. Based on this, the study was undertaken to identify the functional role and mechanism of LINC01572 in HCC progression.Methods: RT-qPCR was used to detect the expressions of LINC01572 in HCC tissues and cell lines. Gain- or loss-of-function assays were applied to evaluate the in vitro and in vivo functional significance of LINC01572 in the HCC cell proliferation, migration, and invasion using corresponding experiments. Bioinformatics, RIP, RNA pull-down, and luciferase reporter assays were performed to explore the regulatory relationship of the LINC01572/miR-195-5p/PFKFB4 signaling axis.Result: In this study, we profiled lncRNAs in HCC tissues and corresponding adjacent tissues from HCC patients with T2DM by RNA sequencing. Our data showed that LINC01572 was aberrantly upregulated in HCC tissues as compared with control, especially in those with concurrent T2DM. The high level of LINC01572 was correlated with advanced tumor stage, increased blood HbA1c level, and shortened survival time. The overexpression of LINC01572 significantly promoted HCC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT), while the knockdown of LINC01572 had the opposite effects on HCC cells. A mechanistic study revealed that LINC01572-regulated HCC progression via sponging miR-195-5p to increase the level of PFKFB4 and subsequent enhancement of glycolysis and activation of PI3K-AKT signaling.Conclusion: LINC01572 acts as ceRNA of miR-195-5p to restrict its inhibition of PFKFB4, thereby enhancing glycolysis and activates PI3K/AKT signaling to trigger HCC malignancy.
Cysteine-Rich Secretory Proteins (CRISP) are Key Players in Mammalian Fertilization and Fertility
Authors: Gonzalez Soledad N. , Sulzyk Valeria , Weigel Muñoz Mariana , Cuasnicu Patricia S. 
Published: December 2021

Mammalian fertilization is a complex process involving a series of successive sperm-egg interaction steps mediated by different molecules and mechanisms. Studies carried out during the past 30 years, using a group of proteins named CRISP (Cysteine-RIch Secretory Proteins), have significantly contributed to elucidating the molecular mechanisms underlying mammalian gamete interaction. The CRISP family is composed of four members (i.e., CRISP1-4) in mammals, mainly expressed in the male tract, present in spermatozoa and exhibiting Ca2+channel regulatory abilities. Biochemical, molecular and genetic approaches show that each CRISP protein participates in more than one stage of gamete interaction (i.e., cumulus penetration, sperm-ZP binding, ZP penetration, gamete fusion) by either ligand-receptor interactions or the regulation of several capacitation-associated events (i.e., protein tyrosine phosphorylation, acrosome reaction, hyperactivation, etc.) likely through their ability to regulate different sperm ion channels. Moreover, deletion of different numbers and combination ofCrispgenes leading to the generation of single, double, triple and quadruple knockout mice showed that CRISP proteins are essential for male fertility and are involved not only in gamete interaction but also in previous and subsequent steps such as sperm transport within the female tract and early embryo development. Collectively, these observations reveal that CRISP have evolved to perform redundant as well as specialized functions and are organized in functional modules within the family that work through independent pathways and contribute distinctly to fertility success. Redundancy and compensation mechanisms within protein families are particularly important for spermatozoa which are transcriptionally and translationally inactive cells carrying numerous protein families, emphasizing the importance of generating multiple knockout models to unmask the true functional relevance of family proteins. Considering the high sequence and functional homology between rodent and human CRISP proteins, these observations will contribute to a better understanding and diagnosis of human infertility as well as the development of new contraceptive options.
Acetylcarnitine Is Associated With Cardiovascular Disease Risk in Type 2 Diabetes Mellitus
Authors: Zhao Shuo , Liu Ming-Li , Huang Bing , Zhao Fu-Rong , Li Ying , Cui Xue-Ting , Lin Rong 
Published: December 2021

ObjectiveThis study aimed to identify the association between specific short-chain acylcarnitines and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM).MethodWe retrieved 1,032 consecutive patients with T2DM who meet the inclusion and exclusion criteria from the same tertiary care center and extracted clinical information from electronic medical records from May 2015 to August 2016. A total of 356 T2DM patients with CVD and 676 T2DM patients without CVD were recruited. Venous blood samples were collected by finger puncture after 8 h fasting and stored as dried blood spots. Restricted cubic spline (RCS) analysis nested in binary logistic regression was used to identify possible cutoff points and obtain the odds ratios (ORs) and 95% confidence intervals (CIs) of short-chain acylcarnitines for CVD risk in T2DM. The Ryan–Holm step-down Bonferroni procedure was performed to adjust p-values. Stepwise forward selection was performed to estimate the effects of acylcarnitines on CVD risk.ResultThe levels of C2, C4, and C6 were elevated and C5-OH was decreased in T2DM patients with CVD. Notably, only elevated C2 was still associated with increased CVD inT2DM after adjusting for potential confounders in the multivariable model (OR = 1.558, 95%CI = 1.124–2.159, p = 0.008). Furthermore, the association was independent of previous adjusted demographic and clinical factors after stepwise forward selection (OR = 1.562, 95%CI = 1.132–2.154, p = 0.007).ConclusionsElevated C2 was associated with increased CVD risk in T2DM.
Effect of Stretching of Spastic Elbow Under Intelligent Control in Chronic Stroke Survivors—A Pilot Study
Authors: Rao Sanjana , Huang Meizhen , Chung Sun Gun , Zhang Li-Qun 
Published: December 2021

Objective:To assess the short-term effects of strenuous dynamic stretching of the elbow joint using an intelligent stretching device in chronic spastic stroke survivors.Methods:The intelligent stretching device was utilized to provide a single session of intensive stretching to the spastic elbow joint in the sagittal plane (i.e., elbow flexion and extension). The stretching was provided to the extreme range, safely, with control of the stretching velocity and torque to increase the joint range of motion (ROM) and reduce spasticity and joint stiffness. Eight chronic stroke survivors (age: 52.6 ± 8.2 years, post-stroke duration: 9.5 ± 3.6 years) completed a single 40-min stretching intervention session. Elbow passive and active ROM, strength, passive stiffness (quantifying the non-reflex component of spasticity), and instrumented tendon reflex test of the biceps tendon (quantifying the reflex component of the spasticity) were measured before and after stretching.Results:After stretching, there was a significant increase in passive ROM of elbow flexion (p= 0.021,r= 0.59) and extension (p= 0.026,r= 0.59). Also, elbow active ROM and the spastic elbow flexors showed a trend of increase in their strength.Conclusion:The intelligent stretching had a short-term positive influence on the passive movement ROM. Hence, intelligent stretching can potentially be used to repeatedly and regularly stretch spastic elbow joints, which subsequently helps to reduce upper limb impairments post-stroke.
Efficacy of Safinamide and Gender Differences During Routine Clinical Practice
Authors: Pellecchia Maria T. , Picillo Marina , Russillo Maria C. , De Pandis Maria F. , Bonizzoni Erminio , Marjanovic Ivan , Cattaneo Carlo 
Published: December 2021

Background: There is increasing evidence of gender differences in the epidemiology and clinical manifestation of both motor and non-motor symptoms of Parkinson's disease (PD). Nevertheless, few data are available on gender differences in the response to antiparkinsonian drugs. Safinamide is a multimodal drug with positive effects on motor and non-motor fluctuations that might improve patients' care and quality of life.Objective: To analyze gender differences on clinical effects of safinamide in PD patients treated in real-life conditions during the SYNAPSES trial.Methods: SYNAPSES was a multinational, multicenter, observational study. At baseline, patients with PD diagnosis received safinamide as an add-on to levodopa and were followed up for 12 months, with visits performed every 4 months. A new statistical analysis was performed to describe the efficacy of safinamide in men and women on motor complications, motor symptoms, and adverse events.Results: Six hundred and sixteen (38%) out of 1,610 patients enrolled in the SYNAPSES study were women and 994 (62%) men. Safinamide improved motor symptoms and motor complications (fluctuations and dyskinesia) in both genders, with a good safety profile and without requiring any change in the concomitant dopaminergic therapy. Clinically significant improvements, according to the criteria developed by Shulman et al., were seen in 46% of male and female patients for the UPDRS motor score and 43.5% of men vs. 39.1% of women for the UPDRS total score.Conclusions: Safinamide was effective in improving motor fluctuations and dyskinesia and proved to be safe in both male and female patients with PD. Further prospective studies, specifically addressing potential gender differences in response to PD therapies, are needed to develop tailored management strategies.
Sensitivity of Physiological Measures of Acute Driver Stress: A Meta-Analytic Review
Authors: Kerautret Laora , Dabic Stephanie , Navarro Jordan 
Published: December 2021

Background: The link between driving performance impairment and driver stress is well-established. Identifying and understanding driver stress is therefore of major interest in terms of safety. Although many studies have examined various physiological measures to identify driver stress, none of these has as yet been definitively confirmed as offering definitive all-round validity in practice.Aims: Based on the data available in the literature, our main goal was to provide a quantitative assessment of the sensitivity of the physiological measures used to identify driver stress. The secondary goal was to assess the influence of individual factors (i.e., characteristics of the driver) and ambient factors (i.e., characteristics of the context) on driver stress. Age and gender were investigated as individual factors. Ambient factors were considered through the experimental apparatus (real-road vs. driving simulator), automation driving (manual driving vs. fully autonomous driving) and stressor exposure duration (short vs. long-term).Method: Nine meta-analyses were conducted to quantify the changes in each physiological measure during high-stress vs. low-stress driving. Meta-regressions and subgroup analyses were performed to assess the moderating effect of individual and ambient factors on driver stress.Results: Changes in stress responses suggest that several measures are sensitive to levels of driver stress, including heart rate, R-R intervals (RRI) and pupil diameter. No influence of individual and ambient factors was observed for heart rate.Applications and Perspective: These results provide an initial guide to researchers and practitioners when selecting physiological measures for quantifying driver stress. Based on the results, it is recommended that future research and practice use (i) multiple physiological measures, (ii) a triangulation-based methodology (combination of measurement modalities), and (iii) a multifactorial approach (analysis of the interaction of stressors and moderators).
Association Between Pre-diagnostic Dietary Supplements Intake and Ovarian Cancer Survival: Findings From a Prospective Cohort Study in Chinese Women
Authors: Gu Jia-Hui , Gong Ting-Ting , Wu Qi-Jun , Liu Fang-Hua , Wen Zhao-Yan , Gao Chang , Wei Yi-Fan , Yang Zhuo 
Published: December 2021

Background: As a result of a limited number of studies and inconsistent findings, there remains uncertainty in whether pre-diagnostic dietary supplements intake affects survival after ovarian cancer (OC) diagnosis.Methods: The association between pre-diagnostic dietary supplements intake and all-cause OC mortality was examined in the OC follow-up study, which included a hospital-based cohort (n = 703) of Chinese women diagnosed with OC between 2015 and 2020. Pre-diagnostic dietary supplements information was collected using self-administered questionnaires. Deaths were ascertained up to March 31, 2021, via death registry linkage. Cox proportional hazards were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the aforementioned association.Results: A total of 130 women died during the median follow-up of 37.2 months (interquartile: 24.7–50.2 months). We found no evidence that any pre-diagnostic dietary supplements intake compared with never is associated with OC survival (HR = 0.75, 95%CI: 0.47–1.18). Furthermore, our study suggested no association for ever supplements intakes of vitamin A (HR = 0.48, 95%CI: 0.07–3.46), vitamin C (HR = 0.64, 95%CI: 0.27–1.54), vitamin D (HR = 1.19, 95%CI: 0.28–5.03), vitamin E (HR = 0.47, 95%CI: 0.06–3.87), multivitamin (HR = 0.49, 95%CI: 0.14–1.67), calcium (HR = 0.96, 95%CI: 0.53–1.72), and fish oil/DHA (HR = 0.31, 95%CI: 0.04–2.37) with OC survival. Interestingly, we only found a detrimental effect of vitamin B supplementation intake (HR = 3.78, 95%CI: 1.33–0.69) on OC survival.Conclusions: We found no evidence that any pre-diagnostic dietary supplements intake is associated with OC survival. Considering lower exposure of dietary supplements before OC diagnosis in the present study, further studies are warranted to confirm these findings.
Gemcitabine Maintenance Therapy in Patients With Metastasized Soft Tissue Sarcomas
Authors: Harrer Dennis Christoph , Buschauer Sebastian , Sterz Ulrich , Menhart Karin , Wendl Christina , Heudobler Daniel , Grube Matthias , Pukrop Tobias , Herr Wolfgang , Vogelhuber Martin 
Published: December 2021

BackgroundMetastasized soft-tissue sarcomas still pose a significant therapeutic challenge given the limited efficacy of currently available multimodal treatment strategies. Recent progress in molecular characterization of sarcoma subtypes has enabled successful personalized therapy approaches in a minority of selected patients with targetable mutations. However, in the majority of patients with refractory soft tissue sarcomas, long-term survival remains poor.MethodsWe report on three adult patients with various soft tissue sarcomas subjected to Gemcitabine maintenance therapy. Tumor entities included leiomyosarcoma of the pancreas (patient 1), undifferentiated pleomorphic sarcoma of the right femur (patient 2), and peri-aortic leiomyosarcoma (patient 3). Metastatic sites encompassed liver, lung, and bones. All patients received Gemcitabine maintenance therapy until disease progression following prior salvage chemotherapy with Docetaxel and Gemcitabine. Patients were treated outside of clinical trials. Response assessment was based on radiological imaging.ResultsIn response to salvage chemotherapy with Docetaxel and Gemcitabine, one patient exhibited a partial remission, and two patients showed stable disease. Patient 1 exhibited stable disease for 6 months during Gemcitabine maintenance therapy before suffering rapid progression of hepatic metastases. Patient 2 underwent 21 months of Gemcitabine maintenance therapy, which was discontinued after progressive pulmonary metastases were detected. Patient 3 is still being treated with Gemcitabine maintenance therapy. Remarkably, owing to significant chemotherapy-associated hematotoxicity, the dose of Gemcitabine dose was reduced by two-thirds. Nevertheless, stable disease with constant pulmonary metastases has been maintained in this patient for 14 months.ConclusionsGemcitabine maintenance therapy following prior Docetaxel and Gemcitabine chemotherapy is manageable and reveals potential benefits for patients with aggressive metastasized soft tissue sarcomas. Prospective trials evaluating Gemcitabine maintenance therapy are encouraged.