bluuebunny/crossref_metadata_2025_split huggingface dataset:
PPP2R5D-Related Neurodevelopmental Disorder or Developmental and Epileptic Encephalopathy?: A Novel Phenotypic Description and Review of Published Cases
Authors: Madaan Priyanka , Kaur Amrit , Saini Lokesh , Paria Pradip , Vyas Sameer , Sharma Amit R. , Sahu Jitendra K. 
Published: August 2021

AbstractBackground Protein phosphatase 2 regulatory subunit B′ delta (PPP2R5D)-related neurodevelopmental disorder is caused by pathogenic variations in the PPP2R5D gene, product of which is involved in dephosphorylation. This is a rare disorder with description limited to case reports. Its phenotypic spectrum has expanded over the last decade.Methods We report a child with a developmental and epileptic encephalopathy phenotype with a pathogenic PPP2R5D variant. This phenotype has not been previously reported. We also reviewed the previously published reports of patients with this disorder.Results Including the index child, 28 cases (15 girls) were identified from nine relevant research items for analysis. All patients had developmental delay. History of seizures was observed in seven patients while macrocephaly was seen in nearly 80% of patients. Nonneurological manifestations were observed in 13 patients with the most common one being ophthalmological manifestations. The most common genetic variation was c.G592A (p.E198K). The common phenotypic associations of this variation were developmental delay, macrocephaly (11/15), and epilepsy (6/15).Conclusion PPP2R5D gene variations should be suspected in children with developmental delay, autistic features, macrocephaly with or without epilepsy in the absence of any clear etiology. Dysmorphic features might provide a diagnostic clue. DEE phenotype may also be the presenting feature and might be an underreported entity.
The Acceptance of Interruptive Medication Alerts in an Electronic Decision Support System Differs between Different Alert Types
Authors: Bittmann Janina A. , Rein Elisabeth K. , Metzner Michael , Haefeli Walter E. , Seidling Hanna M. 
Published: August 2021

Abstract
Background Through targeted medication alerts, clinical decision support systems (CDSS) help users to identify medication errors such as disregarded drug–drug interactions (DDIs). Override rates of such alerts are high; however, they can be mitigated by alert tailoring or workflow-interrupting display of severe alerts that need active user acceptance or overriding. Yet, the extent to which the displayed alert interferes with the prescribers' workflow showed inconclusive impact on alert acceptance.
Objectives We aimed to assess whether and how often prescriptions were changed as a potential result of interruptive alerts on different (contraindicated) prescription constellations with particularly high risks for adverse drug events (ADEs).
Methods We retrospectively collected data of all interruptive alerts issued between March 2016 and August 2020 in the local CDSS (AiDKlinik) at Heidelberg University Hospital. The alert battery consisted of 31 distinct alerts for contraindicated DDI with simvastatin, potentially inappropriate medication for patients > 65 years (PIM, N = 14 drugs and 36 drug combinations), and contraindicated drugs in hyperkalemia (N = 5) that could be accepted or overridden giving a reason in free-text form.
Results In 935 prescribing sessions of 500 274 total sessions, at least one interruptive alert was fired. Of all interruptive alerts, about half of the sessions were evaluable whereof in total 57.5% (269 of 468 sessions) were accepted while 42.5% were overridden. The acceptance rate of interruptive alerts differed significantly depending on the alert type (p <0.0001), reaching 85.7% for DDI alerts (N = 185), 65.3% for contraindicated drugs in hyperkalemia (N = 98), and 25.1% for PIM alerts (N = 185).
Conclusion A total of 57.5% of the interruptive medication alerts with particularly high risks for ADE in our setting were accepted while the acceptance rate differed according to the alert type with contraindicated simvastatin DDI alerts being accepted most frequently.
Dual-mechanism estrogen receptor inhibitors
Authors: Min Jian , Nwachukwu Jerome C. , Min Charles K. , Njeri Jacqline W. , Srinivasan Sathish , Rangarajan Erumbi S. , Nettles Charles C. , Sanabria Guillen Valeria , Ziegler Yvonne , Yan Shunchao , Carlson Kathryn E. , Hou Yingwei , Kim Sung Hoon , Novick Scott , Pascal Bruce D. , Houtman Rene , Griffin Patrick R. , Izard Tina , Katzenellenbogen Benita S. , Katzenellenbogen John A. , Nettles Kendall W. 
Published: August 2021

Significance
To address the unmet clinical need for effectively suppressing estrogen receptor (ER) activity with both de novo resistance and in advanced ER-positive breast cancers that are resistant to standard-of-care antiestrogens, we have developed dual-mechanism ER inhibitors (DMERIs) that employ two distinct ER-targeting moieties. These DMERI elicited noncanonical structural perturbations of the receptor ligand-binding domain and stabilized multiple antagonist substates within the dimer to generate highly efficacious antagonism of proliferation in ER-positive breast cancer cells and in allele-specific resistance models. This work reveals conformational modes by which the activity of ER can be effectively suppressed to block breast cancer proliferation.
Structural basis for the activation of the DEAD-box RNA helicase DbpA by the nascent ribosome
Authors: Wurm Jan Philip , Glowacz Katarzyna-Anna , Sprangers Remco 
Published: August 2021

Significance
DEAD-box RNA helicases are essential cellular enzymes that remodel misfolded RNA structures in an adenosine triphosphate (ATP)-dependent process. The DEAD-box helicase DbpA is involved in the complex and highly regulated process of ribosome maturation. To prevent wasteful hydrolysis of ATP by DbpA, the enzyme is only active when bound to maturing ribosomes. Here, we elucidate the structural basis behind this important regulatory mechanism and find that the recruited ribosome substrate is able to stabilize the catalytically important closed state of the helicase. In addition, our data identify the natural site of action for DbpA in the maturing ribosome and provide a molecular explanation for the observed ribosome maturation defects that result from the overexpression of a DbpA mutant form.
Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1
Authors: Zhang Shilei , Wang Jingfeng , Cheng Genhong 
Published: August 2021

Significance
SARS-CoV-2 has a main protease for viral polyprotein processing. But too few studies addressed this protease’s target of host factors. Here, we screen nearly 300 interferon-stimulated genes (ISGs) and identify that RNF20 is cleaved by 3Clpro, which prevents SREBP1 degradation mediated by RNF20/RNF40 complex, thus promoting SARS-CoV-2 replication. Our study will encourage people to develop drugs against not only coronavirus protease but also host factors.
Rapid sulfuric acid–dimethylamine nucleation enhanced by nitric acid in polluted regions
Authors: Liu Ling , Yu Fangqun , Du Lin , Yang Zhi , Francisco Joseph S. , Zhang Xiuhui 
Published: August 2021

SignificanceNucleation of atmospheric aerosol particles can contribute to nearly half of global cloud condensation nuclei. Nitric acid (NA) is one of the most abundant atmospheric pollutants. A recent study suggested that NA is likely to participate in the sulfuric acid–ammonia nucleation only in the clean and cold upper free troposphere, but its role in the polluted atmospheric boundary layer was not considered. Herein, we found that NA can extensively participate in and significantly enhance the predominant sulfuric acid–dimethylamine nucleation in the polluted boundary layer. Thus, controls on the emissions of nitrogen pollutants are likely significant for the reduction of particulate pollution, especially in the polluted regions.
Hydrogen etch resistance of aluminium oxide passivated graphitic layers
Authors: Kizir Seda , van den Beld Wesley T E , Verbakel Jort D , Pushkarev Roman , Houweling Z Silvester , van de Kruijs Robbert W E , Benschop Jos P H , Bijkerk Fred 
Published: August 2021

Abstract
Graphene inherently possesses defect sites and grain boundaries that are vulnerable to chemical etching by hydrogen radicals. In this study, an etch-mitigation method is presented to selectively passivate these sites using atomic layer deposition (ALD) of a H etch-resistant material. First, as a reference experiment, pristine exfoliated graphitic layers are exposed to H radicals to determine the lateral etch rate from defect sites. Next, these samples are compared to graphitic layers in which the defects are selectively passivated by Al2O3, in the same exposure conditions, using atomic force microscopy at every step in the experiment. The results show that etching is slowed down by local deposition of Al2O3 ALD at sites vulnerable to H radical etching.
Concentration versus absorption for the Vlasov–Navier–Stokes system on bounded domains
Authors: Ertzbischoff Lucas , Han-Kwan Daniel , Moussa Ayman 
Published: August 2021

Abstract
We study the large time behaviour of small data solutions to the Vlasov–Navier–Stokes system set on

Ω
×

R

3

, for a smooth bounded domain Ω of

R

3

, with homogeneous Dirichlet boundary condition for the fluid and absorption boundary condition for the kinetic phase. We prove that the fluid velocity homogenizes to 0 while the distribution function concentrates towards a Dirac mass in velocity centred at 0, with an exponential rate. The proof, which follows the methods introduced in Han-Kwan et al (2020 Arch. Ration. Mech. Anal.
236 1273–323), requires a careful analysis of the boundary effects. We also exhibit examples of classes of initial data leading to a variety of asymptotic behaviours for the kinetic density, from total absorption to no absorption at all.
Experimental study of recombining nitrogen plasmas: II. Electronic population distributions and nonequilibrium radiation of atoms
Authors: Tibère-Inglesse Augustin C , McGuire Sean D , Mariotto Pierre , Laux Christophe O 
Published: August 2021

Abstract
We present optical emission spectroscopy measurements from the vacuum ultraviolet to the near-infrared in a recombining nitrogen plasma flow. An inductively coupled plasma torch is used to create an equilibrium plasma at atmospheric pressure. This plasma is then forced to recombine by flowing through a water-cooled tube. For certain conditions, the plasma is forced out of chemical equilibrium. The emission of excited nitrogen atoms, essential for reentry radiation, is measured to study the nonequilibrium distributions of the electronic states. The densities of the low-lying energy states are found to follow a Boltzmann distribution while the high-lying states are closer to a Saha–Boltzmann distribution—consistent with previous predictions of recombining nonequilibrium plasmas. The measured densities are then compared with the predictions of a two-temperature model, which is found to underpredict the measured densities. The total measured radiation is around 5 orders of magnitude stronger than the equilibrium radiation. The 2-T model estimate of this radiation is much closer yet still underestimates the measured radiation. A model using a single electronic temperature is therefore not sufficient to predict the measurements. The measurements presented in this paper will be useful to test more detailed state-to-state recombination models.
Measurements and analysis of rotational temperatures obtained with Raman and optical emission spectroscopy in a nonequilibrium nitrogen plasma
Authors: Tibère-Inglesse Augustin C , McGuire Sean D , Mariotto Pierre , Laux Christophe O 
Published: August 2021

Abstract
Rotational temperature measurements of N2(B3Πg), N2(C3Πu) and

N

2

+

(

B

2

Σ

u

+

)

obtained by optical emission spectroscopy (OES) are compared with previous gas temperature measurements obtained with Raman spectroscopy in a nonequilibrium recombining nitrogen plasma at atmospheric pressure. The plasma is produced in a state of thermal and chemical equilibrium at about 7000 K using an inductively coupled plasma torch. It is then forced out of chemical equilibrium by imposing rapid cooling through a water-cooled tube. The gas temperature measured by Raman spectroscopy is about 3200 K at the exit of the tube. The rotational temperatures of N2(B) and N2(C) measured with OES are found to be in good agreement with the gas temperature, but the rotational temperature of N2
+(B) is found to be significantly above the gas translational temperature. We propose that this higher rotational temperature is the result of N2
+(B) being formed by the charge exchange reaction between N2(A3Σu
+) and N+. Kinetic and QSS simulations are performed to support this assumption and a rate constant for this reaction is proposed.
Theoretical study of reflection spectroscopy for superconducting quantum parametrons
Authors: Masuda S , Yamaguchi A , Yamaji T , Yamamoto T , Ishikawa T , Matsuzaki Y , Kawabata S 
Published: August 2021

Abstract
Superconducting parametrons in the single-photon Kerr regime, also called KPOs, have been attracting increasing attention in terms of their applications to quantum annealing and universal quantum computation. It is of practical importance to obtain information of superconducting parametrons operating under an oscillating pump field. Spectroscopy can provide information of a superconducting parametron under examination, such as energy level structure, and also useful information for calibration of the pump field. We theoretically study the reflection spectroscopy of superconducting parametrons, and develop a method to obtain the reflection coefficient. We present formulae of the reflection coefficient, the nominal external and the internal decay rates, and examine the obtained spectra. It is shown that the difference of the populations of energy levels manifests itself as a dip or peak in the amplitude of the reflection coefficient, and one can directly extract the coupling strength between the energy levels by measuring the nominal decay rates when the pump field is sufficiently large.
The determination of white dwarf parameters in dwarf novae by optical spectral modeling
Authors: Andreevna Dudnik Anastasiya , Alekseevna Mitrofanova Arina , Vladimirovich Shimansky Vladislav , Vladimirovich Borisov Nikolay , Abdullovich Sakhibullin Nail 
Published: August 2021

Abstract
This paper presents the results of a model analysis of optical spectra and determination of the parameters of three individual SU UMa and WZ Sge type dwarf novae. The moderate resolution spectra of TY Psc, FL Psc and V455 And were obtained at the 6-m BTA of the SAO RAS in the low state of these systems with the determination of white dwarf radiation. The theoretical spectra were calculated using the grid models of hydrogen dwarf atmospheres of white dwarfs by varying the parameters (T
eff and log g) to reach the best agreement with the observed ones. We highlight different effects of the parameters on the shape and intensity of the HI lines. Therefore, it is possible to unambiguously determine T
eff and log g from the analysis of observations. The fundamental parameters of white dwarfs (M and R) were found by comparing the parameters of atmospheres with theoretical models of the internal structure. The obtained parameters of the primaries of TY Psc, FL Psc and V455 And are consistent with the average values for SU UMa and WZ Sge systems. As a result, we demonstrate the efficiency of the method for determining the parameters of such systems based on the analysis of a limited set of observed optical spectra.
A relativistic model of stellar objects with core-crust-envelope division
Authors: Bisht Ravindra K. , Gedela Satyanarayana , Pant Neeraj , Tewari Neeraj 
Published: August 2021

Abstract
In this work, we present a cogent and physically well-behaved solution for neutron stars envisaged with a core layer having quark matter satisfying the MIT-bag equation of state (EoS), meso layer with Bose-Einstein condensate (BEC) matter satisfying modified BEC EoS and an envelope having neutron fluid and Coulomb liquids satisfying quadratic EoS. All the required physical and geometrical parameters like gravitational potentials, pressures, radial velocity, anisotropy, adiabatic index, mass function, compactification factor, and gravitational and surface redshift functions show a feasible trend and are continuous with smooth variation throughout the interior and across the regions of the star. Further, causality condition, energy conditions, static stability criterion (using Tolman-Oppenheimer-Volkoff equation) and Herrera cracking stability criterion are met throughout the star. The approach seems to be resulting in more realistic and accurate modeling of stellar objects, particularly realized by us for X-ray binary stars 4U 1608–52 (M = 1.7 M
⊙, R = 9.5 km) and SAX J1808.4–3658 (M = 1.2 M
⊙, R = 7.2 km). Furthermore, we have ascertained that the continuity of the stability factor in all three regions of the stars demand a smaller core. As the core region of the star increases, the stability factor becomes discontinuous at all the interfaces inside the star.
BGLS-based method of estimating the rotational periods of asteroids
Authors: Ren Yan-Qiong , Lu Xiao-Ping , Liang Yong 
Published: August 2021

Abstract
As the asteroid rotational period is important to the study of the properties of asteroids (e.g., super-fast rotators have structures owing an internal cohesion (rather than being rubble piles bounded by gravity only) so as not to fly apart), constructing an effective and fast method used to search the period attracts much researchers’ attention. Recently, the Bayesian generalized Lomb–Scargle (BGLS) periodogram was developed to improve the convergence efficiency of the Lomb–Scargle method. However, the result of BGLS varies with the frequency range and cannot meet the two minimum/maximum requirements for a complete rotation of the asteroid. We propose a robust BGLS-based method that efficiently determines rotational periods. The proposed method employs a polynomial series to fit folded light curves with potential periods, initially calculated using the BGLS periodogram, and adopts a merit function to estimate and refine best-fit periods. We estimate the rotational periods of 30 asteroids applying the new method to light curves from the Palomar Transient Factory. Results confirm the effectiveness of the BGLS-based method in deriving rotational periods from ground-based observations of asteroids. Further application of the BGLS-based method to sparse light curves, such as Gaia data, is discussed.
Nereid’s orbit based on new precise observations
Authors: Tang Kai , Zhang Hui-Yan , Yu Yong , Yan Dan , Mao Yin-Dun 
Published: August 2021

Abstract
A new orbit of Triton was provided by our previous work, benefitted by new Gaia Data, both in a new precise reduction of charge-coupled device observations and in the planetary ephemeris INPOP19a. In this paper, we provide a new ephemeris for another main Neptunian satellite, Nereid. The orbit is fitted for the newest observations, including 2 075 ground-based observations during the period 1949-2018 and 83 space observations acquired by the Voyager 2 spacecraft in 1989. The dynamical model used here is consistent with that of our previous work. For the ground-based absolute observations of Nereid, the root-mean-square deviations are 0.201″ in right ascension and 0.189″ in declination. Finally, a comparison with the HORIZONS ephemeris is made and discussed.
Power spectral properties of the soft spectral states in four black hole transients
Authors: Mao Dong-Ming , Yu Wen-Fei 
Published: August 2021

Abstract
The X-ray variability in the soft X-ray spectral state of black hole binaries is primarily characterized by a power-law noise (PLN), which is thought to originate from the propagation of the modulation in the mass accretion rate of a standard accretion disk flow. Such a PLN has also been revealed in the disk spectral component in the hard and the intermediate states in several black hole binaries. Here we present an investigation of the Rossi X-ray Timing Explorer (RXTE) observations of four black hole transients in which soft spectral states were observed twenty times or more. We show that in the soft spectral state, the PLN index varied in a large range between –1.64 and –0.62, and the fractional rms variability calculated in the 0.01 – 20 Hz frequency range reached as large as 7.67% and as low as 0.83%. Remarkably, we have found evidence of an inclination dependence of the maximal fractional rms variability, the averaged fractional rms variability and the fractional rms variability of the median in the sample based on current knowledge of inclination of black hole binaries. An inclination dependence has only been predicted in early magnetohydrodynamic simulations of isothermal disks limited to a high-frequency regime. In theory, the noise index is related to the physics of inward propagation of disk fluctuations, while the fractional rms amplitude reflects the intrinsic properties of the magnetohydrodynamic nature of the accretion flow. Our results therefore suggest that X-ray variability in the soft state can be used to put constraints on the properties of the accretion flow as well as the inclination of the accretion disk.
A photometric study of two neglected eclipsing binaries
Authors: Kudak V. , Fedurco M. , Perig V. , Parimucha Š. 
Published: August 2021

Abstract
We present the first BVR photometry, period variation and photometric light curve analysis of two poorly studied eclipsing binaries, V1321 Cyg and CR Tau. Observations were carried out from November 2017 to January 2020 at the observatory of Uzhhorod National University. Period variations were studied using all available early published as well as our minima times. We used the newly developed ELISa code for the light curve analysis and determination of photometric parameters for both systems. We found that V1321 Cyg is a close detached eclipsing system with a low photometric mass ratio of q = 0.28 which suggests that the binary is a post-mass transfer system. No significant period changes in this system are detected. CR Tau is, on the other hand, a semi-detached system where the secondary component almost fills its Roche lobe. We detected a long-term period increase at a rate of 1.49 × 10−7 d yr−1, which supports mass transfer from the lower mass secondary component to the more massive primary.
SETI strategy with FAST fractality
Authors: Chen Yi-Xuan , Liu Wen-Fei , Zhang Zhi-Song , Zhang Tong-Jie 
Published: August 2021

Abstract
We applied the Koch snowflake fractal antenna in planning calibration of the Five-hundred-meter Aperture Spherical radio Telescope (FAST), hypothesizing second-order fractal primary reflectors can optimize the orientated sensitivity of the telescope. Meanwhile, on the grounds of NASA Science Working Group Report in 1984, we reexamine the strategy of Search for Extraterrestrial Intelligence (SETI). A mathematical analysis of the radar equation will be performed in the first section, aiming to make it convenient to design a receiver system that can detect activities of an extraterrestrial civilization, according to the observable region of the narrowband. Taking advantage of the inherent potential of FAST, we simulate the theoretical detection of a Kardashev Type I civilization by a snowflake-selected reflecting area (Drake et al.).