bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRUST, FRIENDS, AND INVESTMENT IN LATE VICTORIAN ENGLAND
Authors: TAYLOR JAMES 
Published: February 2021

AbstractWhy people trust is a question that has preoccupied scholars across many disciplines. Historical explorations of trust abound, but we know relatively little about the workings of trust in the history of investment. Despite becoming increasingly mediated and institutionalized in the nineteenth century, the market for stocks and shares remained local and embedded in personal relations to a significant extent. This created a complex trust environment in which old and new forms of trust co-existed. Investors sought information from the press, but they also relied upon friends to help them navigate the market. Rather than studying trust in the aggregate, this article argues that focusing on the particular allows us to appreciate trust as an emotional and ultimately imaginative process depending as much on affective stories as rational calculation. To this end, it takes the case of a Bath clergyman and workhouse schools inspector, James Clutterbuck, who solicited investments from a wide network of friends and colleagues in the 1880s and 1890s. By capturing the complex interplay of friendship, emotions, and narrative in the formation of trust, the article offers a window onto everyday financial life in late Victorian provincial England.
Do Funding Conditions Explain the Relation Between Cash Holdings and Stock Returns?
Authors: Jensen Tyler K. 
Published: February 2021

AbstractThe prior literature links cash holdings and returns (Simutin (2010), Palazzo (2012)). Using two signals of aggregate-funding availability, I find that the positive association between cash and returns only exists during constrained funding environments. In unconstrained periods, there is no association between cash and returns. The relation in constrained environments does not appear to be related to capital expenditures, expected return, or distress risk but is more prevalent in firms undertaking research and development (R&D) expenditures. This suggests that the association between cash and returns is more consistent with expanding (or maintaining) future growth opportunities rather than being attributable to differences in capital expenditures or risk.
Risk perception, trust and support for wildlife reintroduction and conservation
Authors: Watkins Cristina E , Poudyal Neelam C , Jones Robert E , Muller Lisa I , Hodges Donald G 
Published: February 2021

SummaryWildlife reintroduction projects often face resistance from local residents who see potential conflicts with the species or lack trust or confidence in the agencies and professionals involved in reintroduction. Yet the linkages between trust, confidence, risk perceptions, attitudes towards the species and local support for its reintroduction are not well known. The Dual-Mode Model of Cooperation and Cognitive Hierarchy Model were theoretical frameworks used to shed light on these linkages by exploring the potential roles trust and confidence play as mediators between risk perceptions and attitudes towards, and support for, reintroduced elk in Tennessee (USA). A mail survey of 1005 residents living in the five-county area surrounding the North Cumberland Elk Restoration Zone assessed resident attitudes and risk perceptions towards the reintroduced elk, trust towards the managing wildlife agency and support for continued conservation efforts. A structural equation model revealed that trust and confidence play positive roles in mitigating risk perceptions and improving support for the reintroduction of elk. The findings confirm the roles public trust and confidence play in wildlife reintroductions and should help agencies work towards building local trust and confidence, minimizing risks, improving attitudes and increasing the chances for successful outcomes for the species and people.
Review of historical breeding sites of the Northern Bald IbisGeronticus eremitain Syria and south-eastern Turkey
Authors: SCHENKER ANDRE , SERRA GIANLUCA 
Published: February 2021

SummaryAn updated and comprehensive compilation and review of the historical breeding sites of the Northern Bald Ibis in Syria and south-eastern Turkey is presented accompanied by all available details. The original sources, dating from the first half of the 19th century to 2010, were thoroughly assessed and reviewed. A detailed distribution map of confirmed and unconfirmed historical Northern Bald Ibis colonies was developed, showing a cluster of colonies located in the central steppe of Syria, between the villages of Qaryatayn and Sukhna, while several other colonies were scattered along the Euphrates river from southern Turkey to Iraq, passing through Syria.
Post-operative fever (POF) after cardiac surgery in a low- and middle-income-country: 7-year institutional experience
Authors: Nwafor Ikechukwu A , Eze John C. 
Published: February 2021

AbstractBackground:Post-operative fever (POF) after cardiac surgery in a developing country is of great concern because of the associated morbidity and mortality. In our country, we experience this complication more because of a high rate of malaria infestations, gastroenteritis, and malnutrition. We also experience a low yield of positive diagnostic tests when POF develops; this is partly due to expense and the prioritisation of other essential items in our poorly equipped cardiac ICU.Aims/Objective:To assess the causes of POF after cardiac surgery and determine its impact on the outcome on patients.Materials and methods:International Cardiac Surgery Mission teams visited our centre for 7 years (2013–2019). During this period, a significant number of cardiac surgeries were performed. A retrospective study of patients with POF was performed with data from our hospital’s database, and included standard demographics; types of surgery performed, and management protocols being used in the peri-operative care.Results:A total of 242 patients were treated during the study period and underwent 266 surgeries. Of these, 151 (56.8%) and 115 (43.2%) were adult and paediatric cases respectively. Ages ranged between 0 and 90 years; 34 (14.1%) had POF. When we evaluated the clinical and associated laboratory findings, pyrexia (temp >38.0 °C) and elevated white blood cell count with differential neutrophilia were present in 10 patients (29.4%). The time of onset and duration of POF were between <24 and >144 hours. In the invasive procedure related to POF, sternotomy infections were present in seven patients (18.4%). Malaria infestations and breach in sterility protocol were predominant.Conclusion:The management of POF in the cardiac ICU was complicated by the requirement of co-operation from a larger number of specialties than is usually required in advanced centres with special expertise in malaria confirmation. We, therefore, introduced structured clinical, laboratory, and appropriate interventions to treat POF more aggressively. We found that more careful attention to peri-operative details to ensure strict observation of sterility protocol with anti-malaria prophylaxis led to improvements in our centre’s outcomes.
Holiday heart syndrome: an upcoming tachyarrhythmia in today’s youth?
Authors: Noessler Nathalie , Schweintzger Sabrina , Kurath-Koller Stefan 
Published: February 2021

AbstractAtrial fibrillation is one of the most common arrhythmias in the adult population, in children, however, only a few case reports of isolated atrial fibrillation exist.1 Aside from post-operative AF due to atrial scar formation or suture lines and atrial enlargement in CHD (e.g., mitral stenosis), alcohol consumption represents a rare cause of AF in adolescents. We report on the latter.
Transcatheter closure of post-procedural right ventricular pseudoaneurysms in a neonate with pulmonary atresia
Authors: Jan Sheng-Ling , Wu Chen-Hao , Lin Ming-Chih 
Published: February 2021

AbstractPost-procedural right ventricular pseudoaneurysm is a rare but life-threatening complication of interventional catheterisation. We describe a 3-day-old newborn who underwent transcatheter intervention for pulmonary atresia with a complication of right ventricular pseudoaneurysms, and transcatheter embolisation of the pseudoaneurysms was performed at 3-week-old. It is the first described case that receives transcatheter closure of right ventricular pseudoaneurysms in a newborn with a favourable outcome.
Household food insecurity and school readiness among preschool-aged children in the USA
Authors: Jackson Dylan B , Testa Alexander , Semenza Daniel C 
Published: February 2021

AbstractObjective:The present study examines the association between mild and moderate-to-severe household food insecurity and school readiness among a nationally representative sample of preschool-aged children.Design:Cross-sectional data pertaining to household food availability as well as four domains of school readiness – early learning skills, self-regulation, social-emotional development and physical health & motor development – were employed.Setting:The USA.Participants:15 402 children aged 3–5 years from the 2016–2018 National Survey of Children’s Health.Results:Both mild and moderate-to-severe food insecurity are associated with an increase in needing support or being at-risk in each of the four school readiness domains, particularly Self-Regulation (IRR = 4·31; CI 2·68, 6·95) and Social-Emotional Development (IRR = 3·43; CI 2·16, 5·45). Furthermore, while nearly half of the children in food-secure households are on-track across all four school readiness domains (47·49 %), only one in four children experiencing moderate-to-severe household food insecurity is on-track across all domains (25·26 %).Conclusions:Household food insecurity is associated with reductions in school readiness among preschool-aged children.
Food and nutrient intake and diet quality among older Americans
Authors: Choi Yeon Jin , Crimmins Eileen M , Kim Jung Ki , Ailshire Jennifer A 
Published: February 2021

AbstractObjective:A suboptimal diet and nutritional deficiencies can have important influences on health with significant impact among older adults. This study aims to assess the presence of suboptimal dietary intake among older Americans and identify risk and protective factors influencing diet quality.Design:Cross-sectional secondary analysis.Setting:USA.Participants:A nationally representative sample of 5614 community-dwelling older adults over age 54 in the Health and Retirement Study – Health Care and Nutrition Survey.Results:Overall, only 10·7 % of respondents had a good quality diet (Healthy Eating Index score 81 and above); the majority had diets considered poor or needing improvement. Less than 50 % of respondents met dietary guidelines and nutritional goals for most individual food groups and nutrients. Respondents with low socio-economic status, fewer psychosocial resources and those who had limited access to healthy food outlets were more likely to have a diet of suboptimal quality.Conclusions:Efforts to remove identified barriers that put older adults at risk for poor nutrition and to provide resources that increase access to healthy food should be made to encourage healthy eating and enhance diet quality.
(Re)defining legitimacy in Canadian drug assessment policy? Comparing ideas over time
Authors: Boothe Katherine 
Published: February 2021

AbstractHow do experts judge the legitimacy of technical policy processes, and do their ideas change as these processes are opened to other stakeholders and the public? This research examines the adoption of public and patient involvement in pharmaceutical assessment in Canada. It finds tensions between scientific legitimacy that prioritizes rigor and objectivity, and democratic legitimacy that values inclusion and a broader range of evidence. In response to policy change, experts incorporate new ideas about democratic inputs and processes, while maintaining scientific policy goals. The research responds to calls for more precise measurement of ideas and ideational change and more evaluation of public and patient involvement in health policy. It helps us understand the significance of, and limits to, ideational change among experts in health policy domains that are highly technical and publicly salient. Understanding the way democratic and scientific legitimacy are negotiated in policy decisions has a wide applicability in health, but is particularly relevant during a global pandemic when evidence is being generated rapidly, decisions must be made quickly, and these decisions have a significant, immediate effect on the lives of all citizens.
Empirical Modeling of Thermospheric Nitric Oxide Radiance Based on SABER Observations
Authors: Ruan Haibing , Lei Jiuhou , Jin Shuanggen 
Published: February 2021

AbstractThermospheric nitric oxide (NO) has a strong response to the energy injection, and it serves as the “natural thermostat.” Previous studies have tended to concentrate on NO radiative flux and its effectiveness on the global energy budget rather than the altitudinal dependence. In this study, measurements from TIMED/SABER (the Sounding of the Atmosphere using Broadband Emission Radiometry instrument on TIMED satellite) were used to investigate the variation of the NO radiance cooling in thermosphere as a function of altitude, latitude, and local time. Using the methods of principal component analysis and spherical harmonic regression, we have developed an empirical model to capture the most significant variation in NO radiance cooling for the altitude range 100–280 km. The model reproduced the variations of NO radiation at different latitudes and altitudes. Moreover, the integrated model NO radiative flux is in good agreement with satellite measurements with a correlation coefficient up to 0.96. This empirical model can be used to investigate the NO cooling evolution and serve as a validation tool for future physics‐based simulations.
Novel chemiluminescent immunoassay to measure plasma aldosterone and plasma active renin concentrations for the diagnosis of primary aldosteronism
Authors: Teruyama Kyoko , Naruse Mitsuhide , Tsuiki Mika , Kobayashi Hiroki 
Published: February 2021

AbstractDetermination of plasma aldosterone concentrations (PAC) and plasma active renin concentrations (ARC) is essential for the diagnosis of primary aldosteronism (PA). In Japan, although PAC and ARC are measured by radioimmunoassay and immunoradiometric assay, respectively, non-radioisotopic methods with better detection sensitivity, measurement accuracy, and technical simplicity are needed. We developed two-site sandwich chemiluminescent enzyme immunoassays (CLEIAs) to measure both PAC and ARC using monoclonal antibodies immobilized onto ferrite particles. The results of both assays are obtained simultaneously from a single plasma sample within 30 min using a fully automated system. The novel CLEIAs were validated using plasma samples from patients with PA (n = 52) and essential hypertension (n = 23). The PAC determined by the CLEIA was significantly correlated with that measured by liquid chromatography/mass spectrometry or conventional radioimmunoassay. The ARC determined by the CLEIA was significantly correlated with that measured by immunoradiometric assay. The limits of detection of the CLEIAs for PAC and ARC were 0.1 ng/dl and 0.04 pg/ml, respectively, which were better than those of conventional methods (PAC: 2.5 ng/dl; ARC: 5 pg/ml). The PAC and PAC/ARC ratio (ARR) were significantly higher, and the ARC significantly lower, in patients with PA than in those with essential hypertension. An ARR cut-off of 1.31 ng/dl per pg/ml showed a sensitivity of 96.2% and specificity of 78.3% for PA screening. The newly developed CLEIAs for measuring PAC and ARC could provide a clinically powerful alternative to conventional methods used for hypertension screening in clinical practice.
RETRACTED ARTICLE: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3
Authors: Guo Ziyang , Dai Yingchu , Hu Wentao , Zhang Yongsheng , Cao Zhifei , Pei Weiwei , Liu Ningang , Nie Jing , Wu Anqing , Mao Weidong , Chang Lei , Li Bingyan , Pei Hailong , Hei Tom K. , Zhou Guangming 
Published: February 2021

AbstractAneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial factor of the spindle assembly checkpoint (SAC), to ensure the bi-directional attachment and proper segregation of all sister chromosomes. However, just how MCC is regulated to ensure normal mitosis during cellular division remains unclear. In the present study, we demonstrated that LNC CRYBG3, an ionizing radiation-inducible long noncoding RNA, directly binds with Bub3 and interrupts its interaction with CDC20 to result in aneuploidy. The 261–317 (S3) residual of the LNC CRYBG3 sequence is critical for its interaction with Bub3 protein. Overexpression of LNC CRYBG3 leads to aneuploidy and promotes tumorigenesis and metastasis of lung cancer cells, implying that LNC CRYBG3 is a novel oncogene. These findings provide a novel mechanistic basis for the pathogenesis of NSCLC after exposure to ionizing radiation as well as a potential target for the diagnosis, treatment, and prognosis of an often fatal disease.
HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression
Authors: Li Xiaolei , Su Xiao , Liu Rui , Pan Yongsha , Fang Jiankai , Cao Lijuan , Feng Chao , Shang Qianwen , Chen Yongjing , Shao Changshun , Shi Yufang 
Published: February 2021

AbstractDespite the widespread use of the blockade of immune checkpoints, for a significant number of cancer patients, these therapies have proven ineffective, presumably due to the immunosuppressive nature of the tumor microenvironment (TME). Critical drivers of immune escape in the TME include tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), which not only mediate immune suppression, but also facilitate metastatic dissemination and impart resistance to immunotherapies. Thus, strategies that convert them into tumor fighters may offer great therapeutic potential. In this study, we evaluated whether pharmacologic modulation of macrophage phenotype by HDAC inhibitors (HDACi) could produce an anti-tumor effect. We demonstrated that low-dose HDACi trichostatin-A (TSA) markedly reshaped the tumor immune microenvironment by modulating the suppressive activity of infiltrating macrophages and inhibiting the recruitment of MDSCs in various tumors. These actions, in turn, augmented anti-tumor immune responses and further enhanced anti-tumor effects of immunotherapies. HDAC inhibition, however, also upregulated PD-L1, thereby limiting the beneficial therapeutic effects. Indeed, combining low-dose TSA with anti-PD-L1 in this model significantly enhanced the durability of tumor reduction and prolonged survival of tumor-bearing mice, compared with the effect of either treatment alone. These data introduce HDAC inhibition as a potential means to harness the anti-tumor potential of macrophages in cancer therapy.
DNA methylome profiling of circulating tumor cells in lung cancer at single base-pair resolution
Authors: Zhao Lei , Wu Xiaohong , Zheng Junnian , Dong Dong 
Published: February 2021

AbstractDNA methylation plays a pivotal role in regulating cellular processes, and altered DNA methylation pattern is a general hallmark of cancer. However, DNA methylome in circulating tumor cells (CTCs) is still a mystery due to the lack of proper analytical techniques. We introduced an efficient workflow, LCM–µWGBS, which can efficiently profile the DNA methylation of microdissected CTC samples. LCM–µWGBS combines the laser capture microdissection (LCM)-based CTC capture method and whole-genome bisulfite sequencing in very small CTC population (µWGBS) to gain insight into the DNA methylation landscape of CTCs. We herein profiled the DNA methylome of CTCs from lung cancer patients. Deriving from a comprehensive analysis of CTC methylome, a unique “CTC DNA methylation signature” that is distinct from primary lung cancer tissues was identified. Further analysis showed that promoter hypermethylation of epithelial genes is a hallmark of stable epithelial–mesenchymal transition process. Moreover, it has been suggested that CTCs are endowed with a stemness-related feature during dissemination and metastasis. This work constitutes a unique DNA methylation analysis of CTCs at single base-pair resolution, which might facilitate to propose noninvasive CTC DNA methylation biomarkers contributing to clinical diagnosis.
The amphibian microbiome exhibits poor resilience following pathogen-induced disturbance
Authors: Jani Andrea J , Bushell Jessie , Arisdakessian Cédric G , Belcaid Mahdi , Boiano Daniel M , Brown Cathy , Knapp Roland A 
Published: February 2021

Abstract
Infectious pathogens can disrupt the microbiome in addition to directly affecting the host. Impacts of disease may be dependent on the ability of the microbiome to recover from such disturbance, yet remarkably little is known about microbiome recovery after disease, particularly in nonhuman animals. We assessed the resilience of the amphibian skin microbial community after disturbance by the pathogen, Batrachochytrium dendrobatidis (Bd). Skin microbial communities of laboratory-reared mountain yellow-legged frogs were tracked through three experimental phases: prior to Bd infection, after Bd infection (disturbance), and after clearing Bd infection (recovery period). Bd infection disturbed microbiome composition and altered the relative abundances of several dominant bacterial taxa. After Bd infection, frogs were treated with an antifungal drug that cleared Bd infection, but this did not lead to recovery of microbiome composition (measured as Unifrac distance) or relative abundances of dominant bacterial groups. These results indicate that Bd infection can lead to an alternate stable state in the microbiome of sensitive amphibians, or that microbiome recovery is extremely slow—in either case resilience is low. Furthermore, antifungal treatment and clearance of Bd infection had the additional effect of reducing microbial community variability, which we hypothesize results from similarity across frogs in the taxa that colonize community vacancies resulting from the removal of Bd. Our results indicate that the skin microbiota of mountain yellow-legged frogs has low resilience following Bd-induced disturbance and is further altered by the process of clearing Bd infection, which may have implications for the conservation of this endangered amphibian.