bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of mobile phone text message reminder interventions to improve adherence to antiretroviral therapy among adolescents living with HIV: A systematic review and meta-analysis
Authors: Mehra Nishant , Tunje Abayneh , Hallström Inger Kristensson , Jerene Degu 
Published: July 2021

Background
Poor adherence to antiretroviral therapy in adolescents living with HIV is a global challenge. One of the key strategies to improve adherence is believed to be the use of digital adherence tools. However, evidence is limited in this area. Our objective was to investigate the effectiveness of mobile phone text message reminders in improving ART adherence for adolescents.

Methods
The preferred reporting item for systematic review and meta-analysis guideline was followed. A literature search was done in five databases (PubMed, Web of Science, Embase, Global Health and Cochrane) in August 2020. Additional searches for studies and grey literature were performed manually. We included studies with quantitative design exploring the effectiveness of text message reminders, targeting adolescents aged 10–19 years. Studies were excluded if the intervention involved phone calls, phone-based applications, or other complex tech services. Mean differences between intervention and standard of care were computed using a random effects model. Subgroup analyses were performed to identify sources of heterogeneity between one-way and two-way text messages.

Results
Of 2517 study titles screened, seven eligible studies were included in the systematic review. The total number of participants in the included studies was 987, and the study sample varied from 14 to 332. Five studies showed a positive impact of text messaging in improving adherence, while no significant difference was found between the intervention and the control (standard of care) group in the remaining two studies. The pooled mean difference between the intervention and the control group was 0.05 (95% CI: –0.08 to 0.17). There was considerable heterogeneity among the studies (I2 = 78%).

Conclusion and recommendation
The meta-analysis of text message reminder interventions did not show a statistically significant difference in the improvement of ART adherence among adolescents living with HIV. The included studies were heterogeneous in the reported clinical outcomes, where the effectiveness of the intervention was identified in small studies which had a short follow-up period. Studies with bigger sample size and a longer follow-up period are needed.
Supporting communication of visit information to informal caregivers: A systematic review
Authors: Bratches Reed W. R. , Scudder Paige N. , Barr Paul J. 
Published: July 2021

Importance
When caregivers cannot attend the clinic visit for the person they provide care for, patients are the predominant source of clinic visit information; however, poor patient recall inhibits the quality of information shared, resulting in poor caregiver preparedness and contributing to caregiver morbidity. Technological solutions exist to sharing clinic visit information, but their effectiveness is unclear.

Objectives
To assess if and how technology is being used to connect informal caregivers to patient clinic visit information when they cannot otherwise attend, and its impact on caregiver and patient outcomes.

Evidence review
MEDLINE, Cochrane, Scopus, and CINAHL were searched through 5/3/2020 with no language restrictions or limits. ClinicalTrials.gov and other reference lists were included in the search. Randomized controlled trials (RCTs) and nonrandomized trials that involved using a technological medium e.g., video or the electronic health record, to communicate visit information to a non-attending caregiver were included. Data were collected and screened using a standardized data collection form. Cochrane’s Risk of Bias 2.0 and the Newcastle-Ottawa Scale were used for RCTs and nonrandomized trials, respectively. All data were abstracted by two independent reviewers, with disagreements resolved by a third reviewer.

Findings
Of 2115 studies identified in the search, four met criteria for inclusion. Two studies were randomized controlled trials and two were nonrandomized trials. All four studies found positive effects of their intervention on caregiver outcomes of interest, and three out of four studies found statistically significant improvements in key outcomes for caregivers receiving visit information. Improved outcomes included caregiver happiness, caregiver activation, caregiver preparedness, and caregiver confidence in managing patient health.

Conclusions and relevance
Our review suggests that using technology to give a caregiver access to clinical visit information could be beneficial to various caregiver outcomes. There is an urgent need to address the lack of research in this area.
Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results
Authors: Halfon Philippe , Ansaldi Christelle , Penaranda Guillaume , Chiche Laurent , Dukan Patrick , Stavris Chloé , Plauzolles Anne , Retornaz Frédérique , Bourliere Marc 
Published: July 2021

Background & aim
Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test combining age, transaminases, platelets count, developed for the diagnosis of advanced fibrosis. The aim of our study was to evaluate the interest of liver fibrosis screening using systematic calculation of FIB-4 in routine blood analysis.

Methods
Between December 2018 and May 2019, we conducted a prospective screening of liver fibrosis in 134 158 patients during a medical check-up including routine blood analysis. Among these patients, 29 707 had transaminases and platelets counts available and benefited from an automatic calculation of FIB-4. Results were obtained from 21 French clinical laboratories in the Bouches du Rhône region.

Results
Among the 29 707 patients, 2161 (7.3%) had a high risk of advanced fibrosis (FIB-4>2.67). Individual investigation of patients with FIB-4>2.67 allowed to screen 1268 (1268/2161: 58.7%) patients who were not managed for any liver disease.

Conclusions
This work demonstrates the interest of FIB-4 for the screening of liver fibrosis in primary care population. Although additional clinical validation study is required to determine the utility and applicability of Fib-4 to daily practice, our study strongly supports this easy-to-implement strategy using a simple Fib-4 measure resulting from the use of available routine test results.
Long-term effect of botulinum toxin A on the hip and spine in cerebral palsy: A national retrospective cohort study in Taiwan
Authors: Lin Ching-Yueh , Chung Chi-Hsiang , Matthews Dennis J. , Chu Heng-Yi , Chen Liang-Cheng , Yang Sung-Sen , Chien Wu-Chien 
Published: July 2021

ObjectivesTo investigate the effect of botulinum toxin A (BTA) on the development of hip dislocation and scoliosis, surgical rates for hip and spine, and mortality in cerebral palsy (CP).Study designA cohort study was conducted using CP data from a Taiwan National Insurance Health Research Database. Diagnoses were defined using the International Classification of Diseases codes, 9th revision. Adjusted hazard ratios for outcomes were calculated using Cox regression analysis and adjusted for the following variables: BTA injection, sex, age, severities of CP, comorbidities, location, urbanization level, and level of care.ResultsA total of 1,405 CP children (670 female vs. 735 male), 281 in the BTA group and 1,124 in the controls, were followed-up for a mean of 5 years 4 months. There were no significant differences in the outcomes in both groups, in the incidence rates of hip dislocation and scoliosis, nor in the surgical rates for hip and spine surgery. Mortality rate in the BTA group was 0.49 times lower than that in the controls (p= 0.001). Moderate to severe types of CP had higher incidence rates of hip dislocation, scoliosis, hip surgery, spine surgery, and mortality.ConclusionModerate to severe types of CP had poorer outcomes in all aspects, including a higher risk of hip dislocation, scoliosis, surgical rate for hip and spine, and mortality. Although BTA injection in children with CP proved to not significantly reduce hip dislocation and scoliosis, it is considered safe as an anti-spasticity treatment and may be beneficial for survival.
Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders
Authors: Wolff Jan , Reißner Pamela , Hefner Gudrun , Normann Claus , Kaier Klaus , Binder Harald , Hiemke Christoph , Toto Sermin , Domschke Katharina , Marschollek Michael , Klimke Ansgar 
Published: July 2021

Introduction
The aim of this study was to describe the number and type of drugs used to treat depressive disorders in inpatient psychiatry and to analyse the determinants of potential drug-drug interactions (pDDI) and potentially inappropriate medication (PIM).

Methods
Our study was part of a larger pharmacovigilance project funded by the German Innovation Funds. It included all inpatients with a main diagnosis in the group of depressive episodes (F32, ICD-10) or recurrent depressive disorders (F33) discharged from eight psychiatric hospitals in Germany between 1 October 2017 and 30 September 2018 or between 1 January and 31 December 2019.

Results
The study included 14,418 inpatient cases. The mean number of drugs per day was 3.7 (psychotropic drugs = 1.7; others = 2.0). Thirty-one percent of cases received at least five drugs simultaneously (polypharmacy). Almost one half of all cases received a combination of multiple antidepressant drugs (24.8%, 95% CI 24.1%–25.5%) or a treatment with antidepressant drugs augmented by antipsychotic drugs (21.9%, 95% CI 21.3%–22.6%). The most frequently used antidepressants were selective serotonin reuptake inhibitors, followed by serotonin and norepinephrine reuptake inhibitors and tetracyclic antidepressants. In multivariate analyses, cases with recurrent depressive disorders and cases with severe depression were more likely to receive a combination of multiple antidepressant drugs (Odds ratio recurrent depressive disorder: 1.56, 95% CI 1.41–1.70, severe depression 1.33, 95% CI 1.18–1.48). The risk of any pDDI and PIM in elderly patients increased substantially with each additional drug (Odds Ratio: pDDI 1.32, 95% CI: 1.27–1.38, PIM 1.18, 95% CI: 1.14–1.22) and severity of disease (Odds Ratio per point on CGI-Scale: pDDI 1.29, 95% CI: 1.11–1.46, PIM 1.27, 95% CI: 1.11–1.44), respectively.

Conclusion
This study identified potential sources and determinants of safety risks in pharmacotherapy of depressive disorders and provided additional data which were previously unavailable. Most inpatients with depressive disorders receive multiple psychotropic and non-psychotropic drugs and pDDI and PIM are relatively frequent. Patients with a high number of different drugs must be intensively monitored in the management of their individual drug-related risk-benefit profiles.
APPLICATION OF PIEZOSENSORS BASED ON THE MOLECULARLY IMPRINTED POLYIMIDE FOR DETERMI-NATION OF CAFFEINE IN TEA
Authors: Cao Nhat Linh , Duvanova Ol'ga Vasil'yevna , Zyablov Aleksandr Nikolayevich , Nguyen Anh Tien 
Published: July 2021

In this article the molecularly imprinted polymers (MIPs) have been synthesized on the surface of piezosensors. The starting polymer for MIPs production was polyamic acid, which is a copolymer of 1,2,4,5-benzenetetracarboxylic acid and 4,4′-diaminodiphenyl ether. The caffeine served as the template. The quantum-chemical simulation was performed by the Gaussian 09 software using the DFT method at the B3LYP/6-31G(d,p) level with the basis set superposition error (BSSE) at the preliminary stage of the synthesis of the MIP for caffeine. The prepolymerization complexes were calculated to establish intermolecular interactions and obtain the optimum molar ratio between the template and polyamiс acid. It is shown that the constitutional repeating units of polyamic acid interact with the caffeine by forming H-bonds via carboxyl groups. The interaction energy first increases and then decreases with increasing the molar ratio of imprinting. Based on the quantum-chemical calculations, the optimal ratio of the reagents in prepolymerization mixture was set to 1 : 3 with the highest interaction energy (96.7 kJ/mol). Applying thermal imidization of solution of polyamic acid in the presence of a template, the molecularly imprinted polyimide has been synthesized by the non-covalent imprinting method. The ability of the obtained piezosensors to recognize the tempalte in model mixtures was experimentally evaluated. It was found that the range of detectable concentrations of caffeine is 3.1.10-6-10-1 mol/dm3 and the detection limit is 10-6 mol/dm3. Correctness of the caffeine determination in model solutions was verified in the spike/recovery tests. Piezosensors based on MIP were approved for the determination of the caffeine in tea varieties. It is shown that the concentration of caffeine in the aqueous solution increases with increasing brewing time. The relative standard deviation is less than 8%.
ANTIRADICAL ACTIVITY OF EXTRACTIVES FROM THE ACHILLEA MILLEFOLIUM L. OF THE SIBERIAN REGION
Authors: Efremov Aleksandr Alekseyevich , Zykova Irina Dement'yevna 
Published: July 2021

In model reactions with a free stable 2,2-diphenyl-1-picrylhydrazyl radical, the antiradical properties of extractives of common yarrow (Achillea millefolium L.) growing in the Krasnoyarsk Territory were studied: water-alcohol extracts with an alcohol content of 20, 40 and 70% and essential oil. Whole essential oil is obtained by exhaustive hydro-steam distillation for 11 hours. In addition, separate oil fractions were obtained: the first after 20 minutes from the start of distillation, the second after the next 50 minutes, the third after the next 180 minutes, and the fourth after the next 360 minutes.
The results of the DPPH test showed that ARA is minimal for alcohol-soluble substances and increases for aqueous-alcoholic extracts from 20.3% in the case of a 20% extract to 21.8% for a 70% aqueous-alcoholic extract. ARA of the obtained samples of essential oil surpasses the ARA values of aqueous, alcoholic and aqueous-alcoholic extracts. It was found that the APA value for 1 fraction of oil is 29.7% and increases with the transition to subsequent fractions to 54.3%. Whole Yarrow essential oil has an ARA value of 52.8%.
According to the ARA value, the extractives of yarrow can be arranged in the following row: whole essential oils> 70% aqueous-alcoholic extract> 40% extract> 20% extract> aqueous extract> 96% alcoholic extract.
SYNTHESIS, STRUCTURE AND PROPERTIES OF ORGANIC GELS BASED ON LARCH BARK TANNINS AND HY-DROLYSIS LIGNIN
Authors: Mikova Nadezhda Mikhailovna , Mazurova Elena Valentinovna , Ivanov Ivan Petrovich , Kuznetsov Boris Nikolayevich 
Published: July 2021

For the first time, tannin-lignin-formaldehyde and tannin-lignin-furfuryl organic gels were obtained on the basis of larch bark tannins and hydrolysis lignin by sol-gel condensation with formaldehyde and furfuryl alcohol. Their physico-chemical properties were studied by varying the content of lignin (from 5 to 30 wt%) and a fixed mass ratio of polyphenolic substances to the crosslinking reagent (1 : 1.5). With an increase in the lignin content the density of tannin-lignin formaldehyde gels decreases from 0.83 to 0.53 g/ cm3, and that of tannin-lignin-furfuryl gels is from 0.32 to 0.14 g / cm3. According to the FTIR data, the structures of tannin-lignin-formaldehyde and tannin-lignin-furfuryl gels are formed by aromatic fragments cross-linked with methylene and methylene-ether bridges. Scanning electron microscopy shows that the addition of appropriate amounts of lignin to tannins (up to 10 wt% when using formaldehyde and up to 20 wt% when using furfuryl alcohol) promotes the formation of gels with a more developed porous structure. In the case of tannin-lignin-formaldehyde gel, the specific surface area and sorption of methylene blue are 12 m2 / g and 43 mg / g and for tannin-lignin-furfuryl gel – 72 m2 / g and 114.5 mg/g, respectively. It was found that an increase in the lignin content in the gel composition over 20 wt.% is accompanied by the phase localization of lignin (precipitation), which reduces the strength of the resulting gel and reduces its specific surface area.
The effect of drone transport on the stability of biochemical, coagulation and hematological parameters in healthy individuals
Authors: Perlee Desirée , van der Steege Klaas Henk , den Besten Gijs 
Published: July 2021

Abstract

Objectives
Transport of blood tubes is mainly by car or pneumatic transport. The transportation of blood tubes by drones is a novel approach for rapid transportation of blood tubes over long distances. However, limited data on the stability of biochemical, coagulation and hematological parameters is available after transport of blood tubes by drone.

Methods
To investigate the effect of drone transport on the stability of blood parameters, four test flights were performed. Blood was drawn from 20 healthy individuals and 39 of the most frequently measured blood parameters were compared between 4 groups; immediate measurement (control), late measurement, transport by car and transport by drone. Total allowable error (TAE) of the EFLM Biological Variation Database was used to determine the clinical relevance of significant differences.

Results
The majority of blood parameters were not affected by drone transport. Eight of the measured parameters showed significant differences between all the groups; glucose, phosphate, potassium, chloride, hemoglobin, platelet count, activated partial thromboplastin time (APTT) and lactate dehydrogenase (LD). A clinically relevant increase for LD after transport and a decrease for glucose values in time and after transport compared with the control group was shown.

Conclusions
Transportation of blood tubes from healthy individuals by drones has a limited clinically relevant effect. From the 39 investigated blood parameters only LD and glucose showed a clinically relevant effect.
Driver intervention performance assessment as a key aspect of L3–L4 automated vehicles deployment
Authors: Rodak Aleksandra , Budziszewski Paweł , Pędzierska Małgorzata , Kruszewski Mikołaj 
Published: July 2021

Abstract
In L3–L4 vehicles, driving task is performed primarily by automated driving system (ADS). Automation mode permits to engage in non-driving-related tasks; however, it necessitates continuous vigilance and attention. Although the driver may be distracted, a request to intervene may suddenly occur, requiring immediate and appropriate response to driving conditions. To increase safety, automated vehicles should be equipped with a Driver Intervention Performance Assessment module (DIPA), ensuring that the driver is able to take the control of the vehicle and maintain it safely. Otherwise, ADS should regain control from the driver and perform a minimal risk manoeuvre. The paper explains the essence of DIPA, indicates possible measures, and describes a concept of DIPA framework being developed in the project.
Influence of the applied pressure of the transducer on the propagation speed of the ultrasonic wave in wood
Authors: Carrasco Edgar V.M. , Alves Rejane C. , Smits Mônica A. , Pizzol Vinnicius D. , Oliveira Ana Lucia C. , Mantilla Judy N. R. 
Published: July 2021

Abstract
The non-destructive wave propagation technique is used to estimate the wood’s modulus of elasticity. The propagation speed of ultrasonic waves is influenced by some factors, among them: the type of transducer used in the test, the form of coupling and the sensitivity of the transducers. The objective of the study was to evaluate the influence of the contact pressure of the transducers on the ultrasonic speed. Ninety-eight tests were carried out on specimens of the species Eucalyptus grandis, with dimensions of 120 × 120 × 50 mm. The calibration of the pressure exerted by the transducer was controlled by a pressure gauge using a previously calibrated load cell. The robust statistical analysis allowed to validate the experimental results and to obtain consistent conclusions. The results showed that the wave propagation speed is not influenced by the pressure exerted by the transducer.
Correlates of food intake and mealtime behaviors among Kuwaiti adolescents
Authors: Zafar Tasleem A. , Alkazemi Dalal 
Published: July 2021

Abstract

Objectives
Eating meals with the family improves the food choices of adolescents. Studies conducted on Kuwaiti adolescents have reported suboptimal dietary intake; however, it is unclear what meal-related behaviors and family dynamics influence dietary choices in young Kuwaiti adolescents. This study explored the food intake and meal-related behaviors of young adolescents in relation to their mother’s educational level, parental employment, and family size and to identify meal-related behaviors associated with poor dietary choices.

Content
A cross-sectional survey was conducted using a modified and validated version of the International Health Behavior in School Children questionnaire recruiting 774 adolescents aged 14–16 years from all six governorates of Kuwait.

Summary
A higher level of the mother’s education was associated with higher odds of eating fruits and breakfast. A stay-at-home mother was associated with higher odds of consuming milk and home-made desserts. Larger family size was associated with higher odds of eating fruits, and a higher frequency of family meals was associated with higher odds of consuming vegetables and whole grain bread. All unhealthy snacks, including sweets, potato chips, french fries, home-made desserts, and sugar-sweetened beverages, were associated with higher odds of watching TV during mealtime.

Outlook
A higher level of mother’s education level, large family size, and family meals encouraged consuming fruits, vegetables, whole grain bread, milk, and breakfast, but consuming empty calorie snacks is very common. Family involvement in developing healthy meal-related behaviors is imperative for shaping healthy eating habits of adolescents.
Multiple incompatible datum points identification in vertical control network for high-speed railway based on likelihood ratio test
Authors: Yan Guangfeng , Li Yangtenglong , Liu Chunyan 
Published: July 2021

Abstract
The high-speed railway (HSR) surveying system in China has developed into a modern large-scale precision surveying system with multi-stage structure, large scale, and high precision and reliability requirements. The effective control of the surveying data quality in each stage and each link is a complex but important issue in the processing of surveying data. However, as an important part of surveying system, the study on the data quality control of vertical control network has not attracted as much attention as that of plane control network. Constrained adjustment is the essential link of surveying data processing of HSR vertical control network to obtain the height of new control points. Before that, in addition to the gross errors checking of observations, the compatibility diagnosis of datum points should also be an important step, which is often neglected in practice. In this paper, the likelihood ratio (LR) test with the highest power among all the competitors for simple hypotheses problem is extended to solve the problem of composite hypothesis, resulting in a new multiple incompatible datum points identification strategy (ICDPI-LR). With a benchmark along route control network and a CPIII vertical control network as the example, the performance of the proposed method is demonstrated, and showing the importance and necessity of the identification of incompatible datum points in vertical control network for HSR.