bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absence of hemolytic disease of fetus and newborn despite maternal high-titer IgG anti-Ku
Authors: Kakaiya R.M. , Whaley A. , Howard-Menk C. , Rami J. , Papari M. , Campbell-Lee S. , Malecki Z. 
Published: May 2021

Abstract
Anti-Ku seen in K0(Kell-null) individuals has previously been shown to cause severe hemolytic transfusion reactions. Maternal anti-Ku can cause none or moderate to severe hemolytic disease of the fetus and newborn (HDFN). In two of four previously described HDFN cases, intrauterine transfusions were required because of severe anemia. We report a case in which maternal anti-Ku did not cause HDFN. Standard serologic methods were used for RBC antibody screening and identification, adsorption and elution of RBC antibodies, and antigen typing. A gravida 3, para 3 (G3P3) woman was first evaluated in 2006 and was found to have an IgG RBC antibody that reacted against all panel RBCs in the anti-human globulin phase. A panel of RBCs treated with DTT did not react with the antibody. The antibody failed to react with one example of K0 RBCs. The patient’s RBCs typed negative for the following Kell blood group antigens: KEL1, KEL2, KEL3, KEL4, KEL6, KEL7, KEL11, KEL13, and KEL18. These results established the presence of anti-Ku in maternal serum. The newborn was group A, D+ and required phototherapy for hyperbilirubinemia, but did not require transfusion. The woman was seen again in January 2010 during the third trimester (G4P3). At this time, anti-Ku titer was 256. She delivered a healthy group O, D+ baby boy at 37 weeks’ gestation. Cord RBCs were 4+ for IgG by DAT. An eluate reacted with all RBCs tested, but did not react when tested against a panel of DTT-treated RBCs. K0phenotype is rare to begin with, and the maternal anti-Ku formation may require more than one pregnancy. Therefore, cases that can be evaluated for anti-Ku–related HDFN are rare. Our case contributes to serologic and clinical aspects of such rare cases.
Immunohematology

2010;26:119–122.
The pathophysiology and prevention of transfusion-related acute lung injury (TRALI): a review
Authors: Mair D.C. , Eastlund T. 
Published: May 2021

Abstract
Transfusion-related acute lung injury (TRALI) is a clinically important complication of transfusion that is often difficult to diagnose, is probably underreported, and likely has a multifactorial origin that is incompletely understood, making it challenging to find effective treatments and preventative steps. The spectrum of its severity and clinical symptoms seems wide, but its pathogenesis is most likely associated with pulmonary damage from activated recipient neutrophils. Despite the pathogenesis of TRALI being unclear, many severe cases are related to transfusion of donor WBC antibodies, and preventive measures based on avoiding donations by multiparous donors have been implemented at some sites, with early reports showing benefits. This review will address some of the questions surrounding the etiology of this potentially fatal reaction and how measures, predicated on many severe cases being related to transfusion of plasma from multiparous donors, led to preventive steps to avoid these donations.
Immunohematology

2010;26:161–73.
Comparison of gel test and conventional tube test for antibody detection and titration in D-negative pregnant women: study from a tertiary-care hospital in North India
Authors: Thakur M.K. , Marwaha N. , Kumar P. , Saha S.C. , Thakral B. , Sharma R.R. , Saluja K. , Dhawan H.K. , Jain A. 
Published: May 2021

Abstract
Conventional tube testing was used for antibody screening and titration in D– pregnant women in our hospital until the recent introduction of the gel test. In this study we assessed the sensitivity of the gel test in our setup and tried to establish a correlation between these tests for determining antibody titer. We collected 652 blood samples from 223 antenatal D– women during a span of 1 year. The samples were tested separately by the conventional tube technique and the gel test for antibody detection and titration. The tube test detected 84 (12.8%) positive samples as compared with 93 (14.2%) by gel test, indicating the latter to be more sensitive (p < 0.01). The gel test picked up weakly reactive anti-D that the tube test missed. We did not use any enhancing media such as LISS in titration studies performed by either method in an effort to establish a correlation. However, much higher titers (one- to fivefold) were obtained by the gel test with no clear correlation with the corresponding tube values. When comparing the titer values to the finding of hydrops on ultrasound and Liley’s chart OD reading on amniocentesis, a value of less than 128 (i.e., 64) by gel test corresponded to normal results. Through this study, we thus conclude that the gel test is more sensitive for antibody detection, although a linear correlation could not be established for titers. Clinical correlation may point toward a critical titer of 64 for the gel test, but further studies need to be done to support this finding.
Immunohematology

2010;26:174–77.
The numerical development of MOC for analyzing the inclined pipelines using the experimental network of Babol Noshirvani University as a case study
Authors: Negharchi Saeid Mohammadzade , Shafaghat Rouzbeh 
Published: May 2021

Abstract
Despite the applications of the Method of Characteristics (MOC) for analyzing the unsteady flows, using this method in networks with variable elevations still has many challenges. In this paper, by developing modified correlations as a computer code, the possibility of analyzing inclined pipelines has been evaluated. For validation and calibration, the results of MOC were compared with the results of EPANET software as well as experimental data. To extract experimental data, the water network of Babol Noshirvani University of Technology (NIT) with a constant head of 7 m three loops, and four inclined branches were employed. While evaluating the capabilities of the developed computer code, the results show that for all pipes, as the number of pressure fluctuations in a specific period increases, the intensity of the pressure fluctuations decreases, and the damping speed increases as well. Moreover, in inclined pipes, unlike noninclined pipes, the intensity of pressure fluctuations will increase as the elevation increases and the cross-sectional distance from the transient event increases as well. The evaluation of the effect of space steps on the accuracy of the solution to the MOC shows that in the study network, considering 20 segments for each pipe, the fastest response time with an error of less than 1% is obtained.
Naturalized streamflows and Affluent Natural Energy projections for the Brazilian hydropower sector for the SSP2-4.5 and SSP5-8.5 scenarios of the CMIP6
Authors: Silva Marx Vinicius Maciel da , Silveira Cleiton da Silva , Cabral Samuellson Lopes , Marcos Junior Antonio Duarte , Silva Greicy Kelly da , Sousa Lima Carlos Eduardo 
Published: May 2021

Abstract
Climate change projects an increase in extreme weather events in the coming decades, which could significantly affect Brazil's water and energy security. Thus, this study sought to analyze possible impacts of climate change on the projections of naturalized streamflows and Affluent Natural Energy (ANE) for the Brazilian hydropower sector utilizing five models of the Coupled Model Intercomparison Projects version 6 (CMIP6), based on SSP-4.5 and SSP-8.5 scenarios for the 21st century. Naturalized streamflows for the 24 stations representing the National Interconnected System (NIS) were estimated through the concentrated hydrological model SMAP (Soil Moisture Accounting Procedure), while the streamflows for the other stations that comprise the NIS were obtained by linear regression. The streamflows, as well as the productivity of the reservoirs, were used to calculate the ANE. The results showed that most of the models project possible reductions in annual naturalized streamflows and ANE for the three periods analyzed and for the North, Northeast, and Southeast/Midwest sectors of Brazil. Meanwhile, the Northern and Southern sectors, for the period 2080–2099, most of the models indicated an increase of annual, precipitation, naturalized streamflows and ANE.
Trend and attribution analysis of water and sediment variations in sandy rivers
Authors: Wang Dangwei , Zhang Junhong , Deng Anjun , Jin Yong , Lei Tianjie , Wang Yuhai 
Published: May 2021

AbstractHuman activities and climate change have led to significant changes in the flow and sediment of sandy rivers in northern China. The key work to reveal the changes of river water and sediment conditions is to quantitatively study the changes of precipitation, water and soil conservation in river basins, and the effect of reservoirs on sediment containment. Taking the Yongding River as a case study, we analyze the changing trend of the water and sediment into the Yongding River and find that their amount has greatly decreased. In particular, the sediment yield has decreased by more than 90% and its trend has changed, and the turning point occurred in the 1980s. Based on the statistical data analysis model, the influences of human activities on the sediment inflow of the Guanting Reservoir were quantitatively evaluated. The results show that sand retention of the upper cascade reservoirs is the main reason for the sharp reduction in sediment loads, but the sand retention effect of reservoirs has a certain time limit. Water and soil conservation played a vital role in the sediment loads reduction during the present stage. The present studies may provide insights into understanding the integrated reclamation of the river basin.
Mitochondrial Dysfunction in Alzheimer’s Disease: Opportunities for
Drug Development
Authors: Bhatia Shiveena , Rawal Rishi , Sharma Pratibha , Singh Tanveer , Singh Manjinder , Singh Varinder 
Published: May 2021

:
Alzheimer’s disease (AD) is one of the major reasons for 60-80% cases of senile dementia
occurring as a result of the accumulation of plaques and tangles in the hippocampal and cortical
neurons of the brain leading to neurodegeneration and cell death. The other pathological features of
AD comprise abnormal microvasculature, network abnormalities, interneuronal dysfunction, increased
β-amyloid production and reduced clearance, increased inflammatory response, elevated production of
reactive oxygen species, impaired brain metabolism, hyperphosphorylation of tau, and disruption of
acetylcholine signaling. Among all these pathologies, Mitochondrial Dysfunction (MD), regardless of it
being an inciting insult or a consequence of the alterations, is related to all the associated AD pathologies.
Observed altered mitochondrial morphology, distribution and movement, increased oxidative stress,
dysregulation of enzymes involved in mitochondrial functioning, impaired brain metabolism, and
impaired mitochondrial biogenesis in AD subjects suggest the involvement of mitochondrial malfunction
in the progression of AD. Here, various pre-clinical and clinical evidence establishing MD as a key
mediator in the progression of neurodegeneration in AD are reviewed and discussed with an aim to foster
future MD based drug development research for the management of AD.
La Bioeconomi?a en el Mundo Moderno: una revisio?n de literatura desde los 5 continentes
Authors: Zúñiga Zapata Ana Cristina , Cabezas Aguilar Eduardo Arturo , Pérez Sánchez Elkin Olaguer 
Published: May 2021

El arti?culo hace un recorrido por los pai?ses del mundo que han documentado y puesto a circular informacio?n acerca de la Bioeconomi?a y han hecho definiciones explicitas de poli?ticas o estrategias, y adema?s han establecido lineamientos para su desarrollo. Se entiende la Bioeconomi?a como la gestio?n eficiente y sostenible de la biodiversidad para generar nuevos productos, procesos y servicios con valor agregado, evitando el uso de los recursos naturales no renovables con el fin de promover la innovacio?n tecnolo?gica, desarrollar empleos cualificados y mejorar la calidad de vida de las comunidades en cada una de las localidades y de los pai?ses en general. Para este recorrido se hizo una revisio?n de literatura en bases de datos. Como resultado se presenta a la comunidad acade?mica un panorama de la orientacio?n que se esta? dando a la bioeconomi?a en los diferentes pai?ses del mundo.
Palabras Claves: bioeconomi?a, biomasa y sostenibilidad, biodiversidad, desarrollo sostenible, poli?ticas.
Abstract
The article takes a tour of the countries of the world that have documented and circulated information about the Bioeconomy and made explicit definitions of policies or strategies, and established guidelines for its development. Bioeconomy is understood as the efficient and sustainable management of biodiversity to generate new products, processes and services with added value, avoiding the use of non-renewable natural resources in order to promote technological innovation, develop qualified jobs and improve quality of life of the communities in each of the localities and the countries in general. For this tour, a review of literature in databases was made. As a result, an overview of the orientation that is being given to the bioeconomy in the different countries of the world is presented to the academic community.
Keywords: bioeconomy, biomass and sustainability, biodiversity, sustainable development, policies.

Resumo
Este articulo elabora um recorrido pelos pai?ses do mundo que documentaram e circularam informac?a?o sobre a Bioeconomia e definiram explicitamente poli?ticas ou estrate?gias, y estabeleceram lineamentos para seu desenvolvimento. Entende-se a Bioeconomi?a como a gesta?o eficiente e sustenta?vel da biodiversidade para gerar novos produtos, processos e servic?os com valor agregado, evitando o uso dos recursos naturais na?o-renova?veis com a finalidade de promover a inovac?a?o tecnolo?gica, desenvolver empregos qualificados e melhorar a qualidade de vidas das comunidades em cada uma das localidades, e dos pai?ses em geral. Para isso, houve uma revisa?o da literatura nas bases de dados. Como resultado, apresenta-se a? comunidade acade?mica um panorama da orientac?a?o que se esta? dando a? Bioeconomia nos diferentes pai?ses do mundo.
Palavras chave: bioeconomia, biomassa e sustentabilidade, biodiversidade, desenvolvimento sustenta?vel, poli?ticas
Revista Pensamiento Americano 2013-2016: Palabras clave y su presencia en el tesauro de la UNESCO
Authors: Higuera-Ojito Víctor Hugo , Porto Solano Andrés Felipe , Hurtado Penagos Nelson 
Published: May 2021

El presente arti?culo tiene como objetivo identificar las palabras clave incluidas en dos o ma?s de los arti?culos publicados en la revista Pensamiento Americano durante el peri?odo 2013-2016 que se encuentran en el tesauro de la UNESCO. Para ello, se identifican las palabras clave incluidas en cada arti?culo, se realiza el conteo de arti?culos que incluyen una misma palabra clave, se ordenan aquellas incluidas en dos o ma?s arti?culos y se identifican aquellas que se encuentran en la presentacio?n jera?rquica del tesauro de la UNESCO. Ma?s de la mitad de las palabras clave se encuentran en el tesauro de la UNESCO, por orden de participacio?n, en: 6 Poli?tica, derecho y Economi?a y 7 Pai?ses y agrupaciones de pai?ses, 3 Cultura y 4 Ciencias sociales y humanas y 1 Educacio?n.
PALABRAS CLAVE: Ana?lisis cuantitativo, ciencias de la informacio?n, informacio?n sobre ciencias sociales, medicio?n, tesauro.
Abstract
This article aims to identify the keywords included in two or more of the articles published in Pensamiento Americano journal during the period 2013-2016 that are also included in UNESCO thesaurus. In order to do so, keywords included in each article are identified, articles including the same keywords are counted, keywords included in two or more articles are ordered and those included in UNESCO thesaurus are identified. More than a half of the keywords are found in the UNESCO thesaurus, by order of participation, in 6 Politics, Law and Economics and 7 Countries and country groupings, 3 Culture and 4 Social and human sciences, and 1 Education.
KEYWORDS: Quantitative analysis, information sciences, social science information, measurement, thesauri.

Resumo

Este artigo tem como objetivo identificar as palavras-chave inclui?do em duas ou mais dos artigos publicados no American Journal pensamento durante o peri?odo 2013-2016 encontrada no tesauro UNESCO. Para isso, as palavras-chave em cada artigo identifica a contagem de itens que incluem a mesma palavra-chave e? feito, os inclui?dos em dois ou mais itens esta?o ordenados e aqueles encontrados na apresentac?a?o hiera?rquica da thesaurus identificado UNESCO. Mais de metade das palavras-chave no thesaurus da UNESCO, em ordem de participac?a?o: 6 Poli?tica, Direito e Economia e 7 Pai?ses e grupos de pai?ses, 3 Cultura e 4 Cie?ncias Sociais e Humanas, e 1 Educac?a?o.
PALABRAS-CHAVE: Ana?lise quantitativa, cie?ncia da informac?a?o, informac?a?o sobre cie?ncias sociais, medic?a?o, thesaurus.
ANTIBACTERIAL POTENTIAL OF ESSENTIAL OILS DERIVED FROM NATURAL, CALLUS AND IN-VITRO PROPAGATED SOURCES OF MELALEUCA ALTERNIFOLIA AGAINST COMMON BACTERIAL PATHOGENS
Authors: M. JEYAKANI , A. KUMARI NIRMALA , M. RAJALAKSHMI 
Published: May 2021

Objective: Melaleuca alternifolia (M. alternifolia) and its essential oil (EO) fractions have been used widely and traditionally in the treatment of various infectious diseases and hence its antibacterial potential is investigated in the present study.
Methods: The antibacterial activity was studied through the agar disc diffusion method and broth dilution method, DNA fragmentation studies and confocal microscopy morphological studies were done. In-silico molecular interaction was studied against microbial target using docking software.
Results: The inhibitory concentration of the EOs was recorded at 75% dilution with larger inhibition zones. The DNA fragmentation analyzed in the essential oil derived from in-vitro propagated leaves (EOIPL) of M. alternifolia treated bacterial cultures was compared with negative and positive controls. In Minimum Inhibitory Concentration (MIC) of EOIPL treated Staphylococcus aureus (S. aureus) showed time-dependent growth inhibition. The DNA content in the EOIPL treated bacterial cultures was comparatively less than in control cultures. The cell morphology changes of S. aureus cells were studied through confocal laser scanning microscopic analysis which showed a significant decrease in viable bacterial cells. The active component, terpinen-4-ol docked to autolysin receptor revealed stable interaction with the microbial target.
Conclusion: Thus EOIPL was explored to possess bactericidal activity against common infectious bacteria and could in incorporated in therapeutic natural antibiotic formulations as with future studies.
OPTIMIZATION AND CHARACTERIZATION OF RIVASTIGMINE-LOADED NANOSTRUCTURED LIPID CARRIERS
Authors: GANNA SWATHI , KOTAKADI SAI MANOGNA , MOHAMMED RESHMA ANJUM , SHAIK MANNUR ISMAIL , NANNEPAGA JOHN SUSHMA 
Published: May 2021

Objective: The objective of the present study was to develop Nanostructured lipid carriers (NLCs) for improvement in the oral bioavailability of RT.
Methods: RT-loaded NLCs were prepared by high shear homogenization technique using fish oil and flaxseed oil respectively. The prepared RT-NLCs were characterized using a phase-contrast microscope, scanning electron microscope (SEM), atomic force microscope (AFM), Fourier transform-infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Further, particle size, entrapment efficiency and sustained release of the drug were also studied.
Results: SEM results revealed that the RT-NLCs were spherical in shape with a smooth surface. AFM results confirmed the formation of spherical particle dispersions by the NLCs in nanoscale. FTIR spectroscopy and DSC analyses revealed that there is no chemical interaction between the ingredients of RT-NLCs. The particle size of the RT-NLCs was found to be exponentially decreased with the increase in a surfactant solution.
Conclusion: The results confirmed pronounced improvement in entrapment efficiency of optimized formulation of RT-NLCs. In vitro, drug release studies showed that RT-NLCs were capable of releasing the drug in a sustained manner. The experimental results showed that the NLCs are potential carriers for providing sustained delivery of rivastigmine.
Sociofenomenología de la vida cotidiana en la corresidencia moderna: bases teórico-metodológicas para una hermenéutica de la ciudad
Authors: Márquez Pulido Ulises Bernardino 
Published: May 2021

<p>En este trabajo presento una propuesta teórico-metodológica para el estudio de la sociofenomenología de la vida cotidiana en la ciudad contemporánea a través de la interpretación de la “novela urbana”. Hacemos un recorrido teórico-histórico sobre la importancia de la cotidianidad en las ciencias sociales y humanas, distinguimos las dos grandes perspectivas de estudio: la <em>marxista </em>y la<em> fenomenológica</em>, retomamos a un autor de cada tradición, Henri Lefebvre y Lluís Duch, para realizar la propuesta. Con base en estos insumos, propongo considerar a la “novela urbana” como un “documento” cardinal para la <em>interpretación sociológica</em> de lo cotidiano, que constituiría la base para una <em>hermenéutica de la ciudad</em>.</p><p> </p>
Improved Traditional Drugs: State of knowledge for the sustainable management of gastrointestinal parasitic nematodes of small ruminants
Authors: DANSOU Christian C , KUISEU Julienne , HOUMENOU Géraldo T. , DEGLA Lissette H. , ZINSOU Fréjus T. A. , AZANDO Erick V. B. , ABOH André B. , LAGNIKA Latifou , HOUNZANGBE-ADOTE Mawulé S. , Edorh Patrick A. , OLOUNLADE Pascal Abiodoun 
Published: May 2021

This article aims to present the current state of the fight against gastrointestinal parasites in small ruminants from Improved Traditional Drugs (DTI). A host of scientific documents were consulted by means of search engines to gather the information useful for this synthesis. The failure of conventional treatments has led to the use of new methods to treat digestive pathologies due to internal parasitism in herds of sheep and goats. These include, among others, herbal medicine, homeopathy, aromatherapy, the mixed grazing system for small and large ruminants, ... All plant parts of plants can be used in the preparation of remedies. Several scientific studies show that plants are full of chemical compounds that cause anthelmintic effects on gastrointestinal parasites in small ruminants. Literature searches have revealed that studies on DTIs in the management of gastrointestinal nematodes in small ruminants are non-existent. In addition to the forms (decocted, macerated, infused, etc.) traditionally used by breeders, there are other forms that can be used to make DTIs from plant extracts. There are capsules, capsules, tablets etc. The placing on the market of DTIs requires official authorization based on the safety and reproducibility of the products. From the documents consulted, it appears that scientific research has not yet focused on the formulation of DTIs for the treatment of gastrointestinal parasitic nematodes in small ruminants. It will be useful to manufacture them to facilitate access to veterinary care and the sustainable management of animal health.
Keywords: Improved Traditional Drugs; Gastrointestinal nematodes; Small ruminants, West Africa; Central Africa.