bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes in Ventilated Burn Patients With Acute Respiratory Distress Syndrome: An Evaluation of Early High-PEEP Strategy Using Berlin Criteria
Authors: Perry Travis L , Pinette William , Miner Jason , Lesch Heather , Denny Brittany , Parikh Priti 
Published: September 2021

Abstract
Acute respiratory distress syndrome (ARDS) remains a formidable sequela, complication, and mortality risk in patients with large burns with or without inhalation injury. Alveolar recruitment using higher Positive end expiratory pressures (PEEP) after the onset of ARDS has been tried with varying success. Studies have identified benefits for several rescue maneuvers in ARDS patients with refractory hypoxemia. A prophylactic strategy utilizing an early recruitment maneuver, however, has not, to our knowledge, been explored in ventilated burn patients. This study was designed to evaluate the natural progression and clinical outcomes of ARDS severity (mild, moderate, and severe) using Berlin criteria in ventilated burn patients treated with an early high-PEEP ventilator strategy. A single-center retrospective review of burn patients who were mechanically ventilated for greater than 48 hours utilizing an early high-PEEP &gt;10 mmHg (10.36) ventilator strategy was performed at the Level 1 trauma and regional burn center in Wright State University. ARDS severity was defined according to the Berlin criteria and then compared to published results of ARDS severity, clinical outcomes, and mortality. Demographic data, as well as respiratory and clinical outcomes, were evaluated. Eighty-three patients met inclusion criteria and were evaluated. Utilizing the Berlin definition as a benchmark, 42.1% of patients met ARDS criteria on admission, and most patients (85.5%) developed ARDS within the first seven days: 28 (34%) mild, 32 (38.6%) moderate, and 11 (13.3%) severe ARDS. The mean percent total body surface area was 24.6 + 22.1, with 68.7% of patients diagnosed with inhalation injury. The highest incidence of ARDS was 57.8% on day 2 of admission. Most cases remained in the mild to moderate ARDS category with severe ARDS (2.4%) being less common by hospital day 7. Overall, 30-day in-hospital and inhalation injury mortality rates were 9.6% and 15.8%, respectively. No correlation was observed between plateau pressures (22.8), mean arterial pressures (84.4), or vasopressor requirements; and oxygen requirements down trended quickly over the first 24 to 48 hours. In our study, implementing prophylactic, immediate high-PEEP in mechanically ventilated burn patients was associated with trends toward decreased severity and rapid resolution of ARDS in the first week following burn injury. This correlated with low 30-day in-hospital mortality in this population. This short and less severe course suggests that early high-PEEP support may be a viable protective strategy in the treatment of ventilated burn patients with ARDS.
Enhanced esterase activity during the degradation of dibutyl phthalate by Fusarium species in liquid fermentation
Authors: González-Márquez Angel , Volke-Sepulveda Tania , Díaz Rubén , Sánchez Carmen 
Published: September 2021

Abstract
Dibutyl phthalate (DBP) is one of the most abundantly produced and used plasticizers and is incorporated into plastic to make it more flexible and malleable. DBP has been found to be an environmental contaminant and reported as an endocrine disruptor. Therefore, it is crucial to develop ecofriendly alternatives to eliminate phthalate pollution. In the present research, the growth of F. culmorum and F. oxysporum in the presence of DBP was studied in liquid fermentation. The esterase activity, specific growth rate, and growth and enzymatic yield parameters were determined in DBP-supplemented media (1,500 or 2,000 mg/L) and in control medium (lacking DBP). These results show that in general, for both Fusarium species, the highest esterase activities, specific growth rates, and yield parameters were observed in media supplemented with DBP. It was observed that 1,500 and 2,000 mg of DBP/L did not inhibit F. culmorum or F. oxysporum growth and that DBP induced esterase production in both fungi. These organisms have much to offer in the mitigation of environmental pollution caused by the endocrine disruptor DBP. This study reports, for the first time, esterase production during the degradation of high concentrations (i.e., 1,500 and 2,000 mg/L) of DBP by F. culmorum F. oxysporum.
A 54 Gy in three fractions of stereotactic body radiotherapy using CyberKnife for T1b-2aN0M0 pathologically confirmed non-small cell lung cancer
Authors: Abe Takanori , Ryuno Yasuhiro , Iino Misaki , Saito Satoshi , Aoshika Tomomi , Ohta Tomohiro , Igari Mitsunobu , Hirai Ryuta , Kumazaki Yu , Kaira Kyoichi , Kagamu Hiroshi , Ishida Hironori , Noda Shin-ei , Kato Shingo 
Published: September 2021

Abstract

Objective
Optimal dose-fractionation regimen of stereotactic body radiotherapy for peripheral early-stage non-small cell lung cancer remains unclear. We retrospectively investigated outcomes of stereotactic body radiotherapy using CyberKnife at 54 Gy in three fractions in 26 patients (median age: 76 years) with pathologically confirmed T1b–T2aN0M0 non-small cell lung cancer.

Methods
A 54 Gy in three fractions was prescribed to cover the 99% of gross tumor volume. We estimated cumulative local control, progression-free survival and overall survival rates (Kaplan–Meier method), and toxicity (Common Toxicity Criteria for Adverse Events, version 5.0).

Results
All the tumors were located at peripheral area of lung. Mean distance from chest wall to tumor was 6.5 mm (range: 0–32 mm). The patients’ pathological diagnoses were: adenocarcinoma: n = 18, squamous cell carcinoma: n = 7 and non-small cell carcinoma: n = 1. Their stages were T1b: n = 9, T1c: n = 14 and T2a: n = 3. Median follow-up was 24 months (range: 6–54). Cumulative 2-year effect rates were local control: 100%, progression-free survival 70% and overall survival: 92%. Twenty patients developed grade one radiation pneumonitis, but grade 2 or greater radiation pneumonitis was not observed.

Conclusions
We found CyberKnife-stereotactic body radiotherapy for pathologically confirmed T1b–T2aN0M0 non-small cell lung cancer to be effective and safe. However, these results should be validated with a larger patient cohort and prospective follow-up monitoring.
Soil calcium content as the driving factor for vegetative structure and soil microbial function diverging across a fire chronosequence of the boreal forests in northeast China
Authors: Zhou Zhiyong , Shen Ying , Wang Bo , Zhang Huan 
Published: September 2021

AbstractThe role of biophysical variables in constructing community structure changes with the time since fire. The major objective of this study is to verify the transition stage and its underlying variables for the postfire forest and soil microbial function in the boreal forested area of China. A 50-year fire chronosequence was presented, and biomass of forbs, shrubs and woody plants was separately weighted to assess their contribution to the whole community with the year since fire (YSF). Simultaneously, soil biophysical properties were measured for stands in different time periods after fire. Soil microbial functions, i.e. growth efficiency (GE) and carbon use efficiency (CUE), were calculated based on ecoenzymatic and soil nutrient stoichiometry. In terms of vegetative structure, forbs’ proportion decreased from 75% to 1.5%, but the proportion of woody plants increased from 0.04% to 70% across this fire chronosequence. GE and CUE of soil microorganisms averaged 0.242 and 0.236 and were significantly higher in 9, 15 and 31 YSF than in 2 and 3 YSF. Soil metal content was significantly increased at the late stage of this fire chronosequence, and soil calcium content showed a positive correlation with woody plant biomass and a negative correlation with soil microbial function. Overall, the present work highlights that the time period of 15 and 31 YSF is a hallmark stage for aboveground vegetative structure and soil microbial function to change in different trends and that the calcium content may partly account for these two divergent trajectories.
Rare cases requiring emergency procedures while harvesting a free forearm flap: report of two cases
Authors: Hihara Masakatsu , Hikiami Rina , Mitsui Toshihito , Kakudo Natsuko , Kuro Atsuyuki , Kusumoto Kenji 
Published: September 2021

Abstract
The free forearm flap is considered safe to harvest and is still extremely useful for reconstruction after head and neck tumor resection. We experienced two uncommon cases, in which an emergency procedure was required during reconstructive surgery after resection of head and neck cancer. Case 1 suffered persistent hand blood flow insufficiency long after the flap was placed in the oral cavity. Case 2 had an anomalous cutaneous vein of the forearm that was a drainage vein of the flap. For risk management during free flap surgery, preparing multiple venous transplant options in advance is fundamental.
Military Exposures Predict Mental Health Symptoms in Explosives Personnel but Not Always as Expected
Authors: Barczak-Scarboro Nikki E , Hernández Lisa M , Taylor Marcus K 
Published: September 2021

ABSTRACTObjectiveThe aim of this study was to determine the unique and combined associations of various military stress exposures with positive and negative mental health symptoms in active duty service members.Materials and MethodsWe investigated 87 male U.S. Navy Explosive Ordnance Disposal (EOD) technicians (age M ± SE, range 33.7 ± 0.6, 22-47 years). Those who endorsed a positive traumatic brain injury diagnosis were excluded to eliminate the confounding effects on mental health symptoms. Using a survey platform on a computer tablet, EOD technicians self-reported combat exposure, deployment frequency (total number of deployments), blast exposure (vehicle crash/blast or 50-m blast involvement), depression, anxiety, posttraumatic stress, perceived stress, and life satisfaction during an in-person laboratory session.ResultsWhen controlling for other military stressors, EOD technicians with previous involvement in a vehicle crash/blast endorsed worse mental health than their nonexposed counterparts. The interactions of vehicle crash/blast with deployment frequency and combat exposure had moderate effect sizes, and combat and deployment exposures demonstrated protective, rather than catalytic, effects on negative mental health scores.ConclusionsMilitary stressors may adversely influence self-reported symptoms of negative mental health, but deployment experience and combat exposure may confer stress inoculation.
The SAMI galaxy survey: Mass and environment as independent drivers of galaxy dynamics
Authors: van de Sande Jesse , Croom Scott M , Bland-Hawthorn Joss , Cortese Luca , Scott Nicholas , Lagos Claudia D P , D’Eugenio Francesco , Bryant Julia J , Brough Sarah , Catinella Barbara , Foster Caroline , Groves Brent , Harborne Katherine E , López-Sánchez Ángel R , McDermid Richard , Medling Anne , Owers Matt S , Richards Samuel N , Sweet Sarah M , Vaughan Sam P 
Published: September 2021

ABSTRACT
The kinematic morphology–density relation of galaxies is normally attributed to a changing distribution of galaxy stellar masses with the local environment. However, earlier studies were largely focused on slow rotators; the dynamical properties of the overall population in relation to environment have received less attention. We use the SAMI Galaxy Survey to investigate the dynamical properties of ∼1800 early and late-type galaxies with log (M⋆/M⊙) &gt; 9.5 as a function of mean environmental overdensity (Σ5) and their rank within a group or cluster. By classifying galaxies into fast and slow rotators, at fixed stellar mass above log (M⋆/M⊙) &gt; 10.5, we detect a higher fraction (∼3.4σ) of slow rotators for group and cluster centrals and satellites as compared to isolated-central galaxies. We find similar results when using Σ5 as a tracer for environment. Focusing on the fast-rotator population, we also detect a significant correlation between galaxy kinematics and their stellar mass as well as the environment they are in. Specifically, by using inclination-corrected or intrinsic $\lambda _{R_{\rm {e}}}$ values, we find that, at fixed mass, satellite galaxies on average have the lowest $\lambda _{\, R_{\rm {e}},\rm {intr}}$, isolated-central galaxies have the highest $\lambda _{\, R_{\rm {e}},\rm {intr}}$, and group and cluster centrals lie in between. Similarly, galaxies in high-density environments have lower mean $\lambda _{\, R_{\rm {e}},\rm {intr}}$ values as compared to galaxies at low environmental density. However, at fixed Σ5, the mean $\lambda _{\, R_{\rm {e}},\rm {intr}}$ differences for low and high-mass galaxies are of similar magnitude as when varying Σ5 ($\Delta \lambda _{\, R_{\rm {e}},\rm {intr}} \sim 0.05$, with σrandom = 0.025, and σsyst &lt; 0.03). Our results demonstrate that after stellar mass, environment plays a significant role in the creation of slow rotators, while for fast rotators we also detect an independent, albeit smaller, impact of mass and environment on their kinematic properties.
Temperature-dependent direct photodissociation cross sections and rates of AlCl
Authors: Qin Zhi , Bai Tianrui , Liu Linhua 
Published: September 2021

ABSTRACT
The photodissociation process of aluminium monochloride (AlCl) plays an important role in modelling the chemistry of the circumstellar envelope. In this work, direct photodissociation cross sections of AlCl have been computed for transitions from the ground X1Σ+ state to six low-lying excited electronic states by using ab initio potential energy curves and transition dipole moments, which are obtained by the internally contracted multireference configuration-interaction method with Davidson correction and the aug-cc-pV6Z basis set. State-resolved cross sections for transitions from 38 958 rovibrational levels (υ″ ≤ 100, J″ ≤ 400) of the ground X1Σ+ state have been obtained for photon wavelengths from 500 Å to the dissociation threshold. Photodissociation cross sections in local thermal equilibrium are evaluated for gas temperatures from 500 to 10 000 K. Using the computed cross sections, temperature-dependent photodissociation rates of AlCl in the interstellar and blackbody radiation fields are determined. The results can be applied to the investigation of the chemical evolution of Al in the envelope of carbon-rich and oxygen-rich stars.
An accurate comprehensive approach to substructure – II. Stripped subhaloes
Authors: Salvador-Solé Eduard , Manrique Alberto , Botella Ignacio 
Published: September 2021

ABSTRACT
In Salvador-Solé, Manrique & Botella (Paper I), we used the ConflUent System of Peak trajectories (CUSP) formalism to derive from first principles and no single free parameter the accurate abundance and radial distribution of both diffuse dark matter (dDM) and subhaloes accreted on to haloes and their progenitors at all previous times. Here we use those results as initial conditions for the monitoring of the evolution of subhaloes and dDM within the host haloes. Specifically, neglecting dynamical friction, we accurately calculate the effects of repetitive tidal stripping and heating on subhaloes as they orbit inside the host halo and infer the amount of dDM and subsubhaloes they release into the intrahalo medium. We then calculate the expected abundance and radial distribution of stripped subhaloes and dDM. This derivation clarifies the role of halo concentration in substructure and unravels the origin of some key features found in simulations including the dependence of substructure on halo mass. In addition, it unveils the specific effects of dynamical friction on substructure. The results derived here are for purely accreting haloes. In Salvador-Solé et al. (Paper III), we complete the study by addressing the case of low-mass subhaloes, unaffected by dynamical friction, in ordinary haloes having suffered major mergers.
eIF3j facilitates loading of release factors into the ribosome
Authors: Egorova Tatiana , Biziaev Nikita , Shuvalov Alexey , Sokolova Elizaveta , Mukba Sabina , Evmenov Konstantin , Zotova Maria , Kushchenko Artem , Shuvalova Ekaterina , Alkalaeva Elena 
Published: September 2021

Abstract
eIF3j is one of the eukaryotic translation factors originally reported as the labile subunit of the eukaryotic translation initiation factor eIF3. The yeast homolog of this protein, Hcr1, has been implicated in stringent AUG recognition as well as in controlling translation termination and stop codon readthrough. Using a reconstituted mammalian in vitro translation system, we showed that the human protein eIF3j is also important for translation termination. We showed that eIF3j stimulates peptidyl-tRNA hydrolysis induced by a complex of eukaryotic release factors, eRF1-eRF3. Moreover, in combination with the initiation factor eIF3, which also stimulates peptide release, eIF3j activity in translation termination increases. We found that eIF3j interacts with the pre-termination ribosomal complex, and eRF3 destabilises this interaction. In the solution, these proteins bind to each other and to other participants of translation termination, eRF1 and PABP, in the presence of GTP. Using a toe-printing assay, we determined the stage at which eIF3j functions – binding of release factors to the A-site of the ribosome before GTP hydrolysis. Based on these data, we assumed that human eIF3j is involved in the regulation of translation termination by loading release factors into the ribosome.
Fluoroscopy-Guided High-Intensity Focused Ultrasound Neurotomy of the Lumbar Zygapophyseal Joints: A Clinical Pilot Study
Authors: Perez Jordi , Gofeld Michael , Leblang Suzanne , Hananel Arik , Aginsky Ron , Chen Johnny , Aubry Jean-Francois , Shir Yoram 
Published: September 2021

Abstract

Objective
To investigate the safety and feasibility of a fluoroscopy-guided, high-intensity focused ultrasound system for zygapophyseal joint denervation as a treatment for chronic low back pain.

Methods
The clinical pilot study was performed on 10 participants diagnosed with lumbar zygapophyseal joint syndrome. Each participant had a documented positive response to a diagnostic block or a previous, clinically beneficial radiofrequency ablation. For a descriptive study, the primary outcome was the safety question. All device- or procedure-related adverse events were collected. Secondary outcome variables included the average numeric rating scale for pain, the Roland-Morris Disability Questionnaire, the Brief Pain Inventory, the Patient Global Impression of Change, the morphine equivalent dose, and the finding of the neurological examination.

Results
All participants tolerated the procedure well with no significant device- or procedure-related adverse events; there was one episode of transient pain during the procedure. The average numeric rating scale score for pain decreased from 6.2 at baseline to 2.1 (n = 10) after 1 month, 4.9 (n = 9) after 3 months, 3.0 (n = 8) after 6 months, and 3.0 (n = 6) after 12 months. The ratio of participants who were considered a treatment success was 90% at 1 month, 50% at 3 months, 60% at 6 months, and 40% at 12 months.

Conclusions
The first clinical pilot study using a noninvasive, fluoroscopy-guided, high-intensity focused ultrasound lumbar zygapophyseal neurotomy resulted in no significant device- or procedure-related adverse events and achieved clinical success comparable with that of routine radiofrequency ablation.
Samuel Johnson, Gregory Sharpe, and the Authorship of Some Remarks on the Progress of Learning (1746)
Authors: Lock Frederick P 
Published: September 2021

Abstract
Samuel Johnson wrote far more than he acknowledged or than his contemporaries could identify. Modern scholars have proposed many additions to the canon. Among the most recent of these is Some Remarks on the Progress of Learning (1746), a pamphlet ostensibly written to promote a new edition of Mario di Calasio’s concordance to the Hebrew Bible, then in preparation by William Romaine. The evidence adduced for Johnson’s authorship is partly circumstantial (his connections with the book trade) and partly internal (phrases and features of style that sound Johnsonian). No external evidence connects Johnson with the pamphlet. This article questions the attribution, arguing that neither the circumstantial nor the internal evidence is convincing. Further, the substance of the pamphlet itself, its politics, its religion (especially its view of the Reformation), and most of all its enthusiastic promotion of the study of Hebrew, are quite un-Johnsonian, and indeed contradict his known views. It therefore proposes a more credible candidate, Gregory Sharpe (1713–1771), an ‘enlightened’ cleric and a known enthusiast for Hebrew, and in support, cites parallels with his writings.
Development of an environmental contextual factor item set relevant to global functioning and health in patients with axial spondyloarthritis
Authors: Kiltz Uta , Boonen Annelies , van der Heijde Désirée , Bautista-Molano Wilson , Burgos Vargas Ruben , Chiowchanwisawakit Praveena , El-Zorkany Bassel , Gaydukova Inna , Geher Pal , Gossec Laure , Gilio Michele , Grazio Simeon , Gu Jieruo , Khan Muhammad Asim , Kim Tae-Jong , Maksymowych Walter P , Marzo-Ortega Helena , Navarro-Compán Victoria , Ozgocmen Salih , Patrikos Dimos , Pimentel-Santos Fernando Manuel , Reveille John , Schirmer Michael , Stebbings Simon , Van den Bosch Filip , Weber Ulrich , Braun Juergen 
Published: September 2021

Abstract

Objective
To describe the development of an Environmental contextual factors (EF) Item Set (EFIS) accompanying the disease specific Assessment of SpondyloArthritis international Society Health Index (ASAS HI).

Method
First, a candidate item pool was developed by linking items from existing questionnaires to 13 EF previously selected for the International Classification of Functioning, Disability and Health (ICF) /ASAS Core Set. Second, using data from two international surveys, which contained the EF item pool as well as the items from the ASAS HI, the number of EF items was reduced based on the correlation between the item and the ASAS HI sum score combined with expert opinion. Third, the final English EFIS was translated into 15 languages and cross-culturally validated.

Results
The initial item pool contained 53 EF addressing four ICF EF chapters: products and technology (e1), support and relationship (e3), attitudes (e4) and health services (e5). Based on 1754 responses of axial spondyloarthritis patients in an international survey, 44 of 53 initial items were removed based on low correlations to the ASAS HI or redundancy combined with expert opinion. Nine items of the initial item pool (range correlation 0.21–0.49) form the final EFIS. The EFIS was translated into 15 languages and field tested in 24 countries.

Conclusions
An EFIS is available complementing the ASAS HI and helps to interpret the ASAS HI results by gaining an understanding of the interaction between a health condition and contextual factors. The EFIS emphasizes the importance of support and relationships, as well as attitudes of the patient and health services in relation to self-reported health.