bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using suicide notes to understand suicide among cancer patients: A mixed‐method study
Authors: Men Yu Vera , Yeung Cheuk Yui , Lam Tai‐Chung , Fai Yip Paul Siu , Emery Clifton R. 
Published: October 2021

AbstractBackgroundCancer patients are at risk of suicide. However, no studies have used suicide notes to investigate their expressed reasons for suicide. The objectives of this study were to compare the characteristics between note leavers and non‐leavers among cancer suicide cases and to understand the patterns in expressed reasons for suicide using suicide notes.MethodSuicide cases (2012–2017) were identified from the Hong Kong Coroner's Court reports, which provide detailed information as well as the content of suicide notes. Bivariate tests and multiple logistic regression were performed to compare the characteristics of note leavers and non‐leavers among suicide cases with cancer. Thematic analysis was performed on suicide notes to extract themes of expressed reasons for suicides by cancer status and age group.ResultsAmong cancer suicide cases and compared to non‐leavers, note leavers were younger, more likely to be male, use non‐violent suicide methods, have better housing conditions, and live alone. Suffering from physical disease was a major theme identified among cancer note leavers across all age groups. Young and middle‐aged non‐cancer note leavers had various themes identified. Physical illness was the major theme for elderly non‐cancer note leavers.ConclusionsCancer note leavers had unique characteristics and suffering from physical illness was the major expressed reason identified in the suicide notes. Healthcare professionals should pay attention to the mental as well as the physical needs of patients. Improving quality of life and regaining control of life are vital for suicide prevention among cancer patients.
Proteomic profiles of Zika virus‐infected placentas bearing fetuses with microcephaly
Authors: Quiñones‐Vega Mauricio , Velásquez Erika , Sosa‐Acosta Patricia , Melo Adriana , Garcez Patrícia P. , Nogueira Fábio C.S. , Domont Gilberto B. 
Published: October 2021

AbstractPurposeZika virus (ZIKV) transmission to the fetus during pregnancy could enable a collection of severe fetal malformations like microcephaly (MC), termed Congenital Zika Syndrome (CZS). The mechanisms involved in ZIKV transplacental transmission are not fully understood.Experimental DesignHere we aim to identify in placental tissues the deregulated proteins associated with ZIKV‐induced MC using label‐free proteomics.ResultsWe found proteins associated with DNA damage and gene expression inhibition up‐regulated in infected placentas with no MC fetuses (Z+) compared to the control group (Ctr). Actin filament organization and the immune response were also found deregulated in the Z+ group. In ZIKV‐positive placentas bearing fetuses with MC (MC+) was detected an increase in T cell activation, indicating an elevated immune response. A comparison between MC+ and Z+ groups showed a higher abundance of proteins related to endocytosis and autophagy in MC+, suggesting a higher transcytosis of vesicles with ZIKV particles across the maternal‐fetal interface.Conclusions and Clinical RelevanceOur results suggest that higher expression of integrins in MC+ might be associated with high internalization of the virus since these proteins are known as virus receptors. Similarly, an increased immune response in the placenta and higher infiltration of the virus to the fetus could contribute to the neurological malformation of the CZS.
An Ultrahigh Performance Enzyme‐Free Electrochemical H2O2 Sensor Based on Carbon Nanopores Encapsulated Ultrasmall Cobalt Oxide Nanoparticles
Authors: Yan Tingting , Chen Qian , Wang Yi , Long Yan , Jiang Yanshu , Fan Guangyin 
Published: October 2021

AbstractSmall metal oxide nanoparticles (NPs) that possess abundant accessible active areas and optimal geometric/electronic structures show great promise in electrochemical detection of hydrogen peroxide (H2O2) but remain a synthetic challenge. Herein, a simple adsorption‐annealing synthetic strategy is employed for ultrasmall Co3O4 NPs using the confinement of carbon nanopores in porous carbon (PC). The characterization results indicate that Co3O4 NPs with an ultrafine diameter of 3.01 nm are well distributed on PC (Co3O4/PC−H) with high density because of the carbon nanopore confinement of the support. The achieved Co3O4/PC−H can be used as an excellent electrocatalyst for H2O2 detection, with a high sensitivity of 332 μA mM−1 cm−2, a low detection limit of 1.2 μM, and an excellent linear detection ranges from 0.04 to 20 mM. This catalyst can also be employed for sensing H2O2 in real samples. The large specific surface area and unique morphology and structure of Co3O4/PC−H contribute to the high performance for H2O2 detection. Provided herein is a facile but efficient strategy for the synthesis of enzyme‐free electrochemical H2O2 sensor for analytical applications.
An Overview of Silver‐Catalyzed Mannich Reactions
Authors: Neetha Mohan , Saranya Padinjare Veetil , Philip Rose Mary , Anilkumar Gopinathan 
Published: October 2021

AbstractMannich reactions are one among the most investigated reactions in organic chemistry. Recently, silver‐catalyzed Mannich reactions have gained much recognition owing to the efficiency of silver catalysis. The review encompasses the various strategies towards silver‐catalyzed Mannich reactions and cases literature up to 2021.
Design, Synthesis and Photoluminescence Sensing Property of a Ni‐Organic Material Achieved from 2,6‐Di(1H‐imidazol‐1‐yl) Naphthalene and Carboxylic Acid Ligands
Authors: Liu Zhi‐Qiang , Jin Heng‐Hui , Liu Ran‐Ran , Wang Zhi‐Ping , Huang Hui‐Hui 
Published: October 2021

AbstractA new metal‐organic framework (MOF) compound, [Ni(L)(IDC)(H2O)] ⋅ 0.5 L (1), (H2IDC=4,4′‐iminodibenzoic acid), was synthesized by solvothermal reaction of 2,6‐di(1H‐imidazol‐1‐yl)naphthalene (L) and dicarboxylic acid ligands with nickel salt. The results of single crystal diffraction show that the framework belongs to the P21/c space group and has a unique infinite one‐dimensional (1D) chain structure. They are further linked together through imidazole interaction and finally form a three‐dimensional (3D) structure. The crystal structure was characterized by Powder X‐ray diffraction (PXRD), thermogravimetric analyses (TGA), infrared spectra (IR) and elemental analyses (EA). Meanwhile, the thermal stability and luminescence properties of the crystal were tested. It was found that 1 could recognize acetone molecules by luminescence quenching. It has proved itself an efficient sensor for acetone at low con‐centration.
Facile, Label‐Free, Non‐Enzymatic Electrochemical Nanobiosensor Platform as a Significant Step towards Continuous Glucose Monitoring
Authors: Gangwar Rahul , Subrahmanyam Challapalli , Vanjari Siva Rama Krishna 
Published: October 2021

AbstractThe paper proposes a low‐cost, facile methodology to develop a non‐enzymatic glucose sensor by utilizing the inherent affinity of Boronic Acid moieties towards glucose along with the enhanced electrochemical activity of gold nanoparticles (AuNPs). The AuNPs were electrochemically deposited onto the surface of the indigenous carbon paste wire electrodes to enhance both the active area and the kinetics of the electrodes, thereby increasing the sensitivity of the detection. The sensitivity and limit of detection of the proposed biosensor, as established using Differential Pulse Voltammetry (DPV) and Electrochemical Impedance Spectroscopy (EIS), was found to be 0.0254 [(μA/(mg/dL))/mm2] and 0.085 mg/dL, respectively. The interference and selectivity studies with the most common interference species, such as acrylic acid, uric acid, and salicylic acid, plasma, NaCl, and KCl, carried out resulted in negligible interference. The bio‐electrodes also showed excellent stability and shelf‐life, making them a potential candidate for non‐enzymatic glucose monitoring.
β‐Ketoesters: An Overview and It's Applications via Transesterification
Authors: Rao Gullapalli. B. Dharma , Anjaneyulu Bendi , Kaushik Mahabir. P. , Prasad Mailavaram. R. 
Published: October 2021

AbstractThe transesterification process has attained more significant importance in synthesizing a variety of commercial and non‐commercial β‐ketoesters using alcohols and variety of acetoacetates. β‐Ketoesters have been considered essential synthons in synthetic organic chemistry because of electrophilic and nucleophilic reactive sites and are used as key intermediates in synthesizing the diversity of complex drug molecules. This review provides an overview of the synthesis of β‐ketoesters, various reaction mechanisms, substrate scope, and diverse applications in the bio‐diesel industry and the pharmaceutical industry to synthesize novel drug molecules via transesterification transformation.
Diimides and Aminomethane Based Multifunctional Organic Crystals: Photochromism, Electrochromism, and Application as Cathode in Lithium Battery
Authors: Wu Debo , Zhu Yudie , Jia Wansheng , Ran Youyuan , Wang Li 
Published: October 2021

AbstractOrganic electrode materials evoked wide attention due to the abundance of raw materials. Incorporating redox‐active units into organic electrode materials could expand the functionality of this class of materials. In this work, three organic crystals of OC‐1, OC‐2 and OC‐3 were synthesized based on the reaction between aminomethane and pyromellitic dianhydride (PMDA), 1,4,5,8‐naphthalenete‐tracarboxylicdianhydride (NTCDA), and 3,4,9,10‐perylene‐tetracarboxylicacid‐dianhydride (PTCDA), respectively. The crystals were characterized by X‐ray diffraction, thermogravimetric analyses, infrared spectra and cyclic voltammetry measurements. The results showed that the three crystals exhibited photochromic and electrochromic properties simultaneously due to the generation of free radicals. In addition, these crystals were also investigated as cathode materials for lithium‐ion battery. The resulting battery showed that the first discharge capacities of OC‐1, OC‐2, and OC‐3 could reach to 81.5 %, 93 %, and 87 % of their corresponding theoretical capacities.
Humidity‐Induced Defect‐Healing of Formamidinium‐Based Perovskite Films
Authors: Meng Ke , Wang Chunwu , Qiao Zhi , Zhai Yufeng , Yu Runze , Liu Ning , Gao Rong , Chen Bin , Pan Li , Xiao Mingyue , Chen Gang 
Published: October 2021

AbstractFormamidinium (FA)‐based perovskite material holds great potential to deliver highly efficient commercial solar cells. However, the FA‐based perovskite films are commonly processed under a strictly controlled environment, which would eventually hinder their way to commercialization. Herein, a systematic study is conducted to investigate the sequential deposition of FA‐based perovskite films that are annealed under ambient conditions. Unexpectedly, the films prepared in low humidity condition possess less pinholes and defects and exhibit better device performances than those prepared in the moisture‐free condition. A series of in situ and ex situ investigations are conducted which reveal defects in perovskite films are continuously healed during the film annealing process under the humid condition. This extraordinary effect is attributed to the interaction between water molecules and perovskite. The current study should shed light on the ambient fabrication of FA‐based perovskite solar cells and foster their real‐world applications.
In‐Depth Mechanism Understanding for Potassium‐Ion Batteries by Electroanalytical Methods and Advanced In Situ Characterization Techniques
Authors: Liu Xi , Tong Yong , Wu Yuanji , Zheng Jiefeng , Sun Yingjuan , Li Hongyan 
Published: October 2021

AbstractThe advancement of potassium ion batteries (PIBs) stimulated by the dearth of lithium resources is accelerating. Major progresses on the electrochemical properties are based on the optimization of electrode materials, electrolytes, and other components. More significantly, the prerequisites for optimizing these key compositions are in‐depth and comprehensive exploration of electrochemical reaction processes, including the evolution of morphology and structure, phase transition, interface behaviors, and K+ movement, etc. As a result, the obtained K+ storage mechanism via analyzing aforementioned reaction processes sheds light on furthering practical application of PIBs. Typical electrochemical analysis methods are capable of obtaining physical and chemical characteristics. The advent of in situ electrochemical measurements enables dynamic observation and monitoring, thereby gaining extensive insights into the intricate mechanism of capacity degradation and interface kinetics. By coupling with these powerful electrochemical characterization techniques, inspiring works in PIBs will burgeon into wide realms of energy storage fields. In this review, some typical electroanalytical tests and in situ hyphenated measurements are described with the main concentration on how these techniques play a role in investigating the potassium storage mechanism for PIBs and achieving encouraging results.
Chitosan‐Based Smart Polymeric Hydrogels and Their Prospective Applications in Biomedicine
Authors: Rasool Atta , Rizwan Muhammad , Islam Atif , Abdullah Huda , Shafqat Syed Salman , Azeem Muhammad Khalid , Rasheed Tahir , Bilal Muhammad 
Published: October 2021

AbstractWith increasing scientific research, knowledge, and socioeconomic awareness, research, and industrial communities are now much more interested in biopolymers‐based composite materials with multifaceted functionalities. Biopolymers are easily obtainable, economical, non‐hazardous, and abundant. Several natural and synthetic polymers have been used to prepare hydrogels, microbeads, and microfibers for controlled drug release. Due to marvelous properties, chitosan has been widely explored for medical and pharmaceutical applications. In recent years, considerable attention has been paid to the chitosan‐based hydrogels for biomedical applications, especially for transplantation, and for improving interfacial interactions for the living tissues. Hydrogels can be synthesized by co‐polymerization, condensation, and cross‐linking. This review spotlights recent advances in physicochemical characteristics, modification strategies, and smart blended hydrogels for an array of biomedical and pharmaceutical applications. The whole discussion reveals that among all the biopolymers, chitosan is the finest carrier for biomedical applications.
Detection of SARS‐CoV‐2 in two cats during the second wave of the COVID‐19 pandemic in France
Authors: Fritz Matthieu , Nesi Nicolas , Denolly Solène , Boson Bertrand , Legros Vincent , Rosolen Serge G. , Briend‐Marchal Alexandra , Ar Gouilh Meriadeg , Leroy Eric M. 
Published: October 2021

AbstractAlthough there are several reports in the literature of SARS‐CoV‐2 infection in cats, few SARS‐CoV‐2 sequences from infected cats have been published. In this study, SARS‐CoV‐2 infection was evaluated in two cats by clinical observation, molecular biology (qPCR and NGS), and serology (microsphere immunoassay and seroneutralization). Following the observation of symptomatic SARS‐CoV‐2 infection in two cats, infection status was confirmed by RT‐qPCR and, in one cat, serological analysis for antibodies against N‐protein and S‐protein, as well as neutralizing antibodies. Comparative analysis of five SARS‐CoV‐2 sequence fragments obtained from one of the cats showed that this infection was not with one of the three recently emerged variants of SARS‐CoV‐2. This study provides additional information on the clinical, molecular, and serological aspects of SARS‐CoV‐2 infection in cats.
Discovery of behavioral patterns in online social commerce practice
Authors: Jia Xiaoyun , Wang Ruili , Liu James H. , Jiang Chuntao 
Published: October 2021

AbstractDiscovery of behavioral patterns in online social commerce practice becomes important in this digital era. In this article, we propose a systematic approach to behavioral pattern discovery, and apply it in an emerging online social commerce venue: live streaming. We investigate behavioral patterns in gifting encouragement in live streaming to understand online social commerce practice. Our proposed approach is based on multiple triangulation, including data source triangulation (i.e., streamers, viewers, and actual behavior) and data collection method triangulation (i.e., interviews, focus groups, and observations). Through multiple triangulation, four behavioral patterns of gifting encouragement are discovered: (i) requesting a certain gift for providing a particular service, (ii) creating a raffle, (iii) eliciting competition between individuals, and (iv) eliciting competition between groups. This research reveals the special behavioral patterns in live streaming, and thus increases our knowledge of social commerce practices. This research provides a systematic approach to discover online behavioral patterns, and provides practical implications in live streaming platforms, especially in marketing and platform design.This article is categorized under:
Application Areas > Business and Industry
Future Skills für die Welt von morgen: Das Future-Skills-Triple-Helix-Modell der Handlungsfähigkeit in emergenten Praxiskontexten
Authors: Ehlers Ulf-Daniel 
Published: October 2021

ZusammenfassungIn einer Welt im immer schnelleren Wandel ist die Diskussion um Future Skills eine der aktuellsten in der Bildungsforschung. Dabei wird die Diskussion um Future Skills schon lange geführt (angefangen mit Studien zu Graduate Attributes), ist oft ungreifbar wegen konzeptioneller Unklarheit darüber, was Skills eigentlich sind, und bezieht sich oft nur verkürzt auf digitale Future Skills. Die hier dargestellte Forschung basiert auf einem fundierten empirischen Ansatz, den multimethodischen angelegten, mehrteiligen NextSkills-Studien. Die Intention des Projekts besteht darin, die Nachfrage nach spezifischen Future Skills näher zu erforschen und diese dann im zweiten Schritt auch bildungstheoretisch zu fundieren. Diese Future Skills werden durch das „Future-Skills-Triple-Helix-Modell der Handlungsfähigkeit in emergenten Praxiskontexten“ eingeordnet. Im Einzelnen handelt es sich um Skills, wie beispielsweise Ambiguitätskompetenz, ethische Kompetenz, Selbstkompetenz und anderes.
Die digitale Zukunft des Lernens und Lehrens mit Remote-Laboren
Authors: Ortelt Tobias R. , Terkowsky Claudius , Schwandt Andrea , Winzker Marco , Pfeiffer Anke , Uckelmann Dieter , Hawlitschek Anja , Zug Sebastian , Henke Karsten , Nau Johannes , May Dominik 
Published: October 2021

ZusammenfassungDer Einsatz von Remote-Laboren in ingenieurwissenschaftlichen Studiengängen ermöglicht Studierenden an einigen Hochschulen die ortsunabhängige Nutzung von Laboren, Maschinen und Robotern. Remote-Labore eignen sich in besonderer Weise dafür, den digitalisierungsbedingten Anforderungen und dem Qualifikationsbedarf aus Wirtschaft und Industrie zu begegnen. Die Onlinebedienung von Laboren bietet viele Ansatzpunkte für den Erwerb digitaler Kompetenzen, wie beispielsweise das Sammeln und Analysieren von Big Data, das Entwickeln geeigneter Schnittstellen für den Onlinezugriff oder den korrekten Einsatz zur Verfügung stehender softwarebasierter Messtechnik. Auch während der Coronapandemie im Sommersemester 2020, als der reguläre Zugang zu Laboren aufgrund der Kontaktbeschränkungen nicht erlaubt war, ermöglichten Remote-Labore den Studierenden praktische Erfahrungen. Jedoch stellen nicht nur die didaktischen, sondern auch die technischen und organisatorischen Aspekte ingenieurwissenschaftliche Studiengänge bei der Umsetzung von Remote-Laboren vor anspruchsvolle Aufgaben. Der nachfolgende Beitrag greift diese Aspekte auf und beschreibt anhand ausgewählter Beispiele, wie die Umsetzung und Integration von Remote-Laboren in Studium und Lehre gelingen kann, aber auch welche Herausforderungen nach wie vor bestehen.
On the p-adic Beilinson conjecture and the equivariant Tamagawa number conjecture
Authors: Nickel Andreas 
Published: October 2021

AbstractLetE/Kbe a finite Galois extension of totally real number fields with Galois groupG. Letpbe an odd prime and let$$r>1$$r>1be an odd integer. Thep-adic Beilinson conjecture relates the values at$$s=r$$s=rofp-adic ArtinL-functions attached to the irreducible characters ofGto those of corresponding complex ArtinL-functions. We show that this conjecture, the equivariant Iwasawa main conjecture and a conjecture of Schneider imply the ‘p-part’ of the equivariant Tamagawa number conjecture for the pair$$(h^0(\mathrm {Spec}(E))(r), \mathbb {Z}[G])$$(h0(Spec(E))(r),Z[G]). If$$r>1$$r>1is even we obtain a similar result for Galois CM-extensions after restriction to ‘minus parts’.
Surface-enhanced Raman spectroscopy for the characterization of Vaccinium myrtillus L. bilberries of the Baltic–Nordic regions
Authors: Traksele Lina , Snitka Valentinas 
Published: October 2021

AbstractIn this study, an investigation of the wild bilberries (Vaccinium myrtillus L.) of the different Baltic–Nordic regions using surface-enhanced Raman spectroscopy (SERS) combined with principal component analysis (PCA) is presented. The bilberries were collected in Lithuania, Latvia, Finland and Norway. The set of the SERS spectra of the berry extracts (pH ~ 4) were recorded on the silver nanoparticles based SERS substrates. The SERS spectra of the extracts were acquired using 532 nm laser as an excitation source. The morphology of the SERS substrates was evaluated by scanning electron microscopy (SEM) and the presence of the silver nanoparticles was confirmed by the energy-dispersive X-ray spectroscopy (EDX). The enhancement factor (EF) of the silver SERS substrates was found to be 105. It has been shown that a strong fluorescence background, associated with the phenolic compounds found in bilberries, can be subtracted due to the fluorescence-quenching properties of the silver nanoparticles. Therefore, an application of the SERS technique allowed to observe the characteristic peaks of the bilberries and the PCA tool enabled to evaluate the spectral variation across the entire SERS data set. The results presented in this paper show that the SERS technique coupled with PCA chemometric analysis might serve as a complementary method that allows to identify the country of origin of the bilberries based on the spectral differences.