bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic changes induced by de-activation of lower glycolysis and its advantage on pentose sugar metabolism in Saccharomyces cerevisiae
Authors: Shin Minhye , Park Heeyoung , Kim Sooah , Oh Eun Joong Oh , Jeong Deokyeol , Florencia Clarissa , Kim Kyoung Heon , Jin Yong-Su , Kim Soo Rin 
Published: March 2021

As a microbial host for cellulosic biofuel production, Saccharomyces
cerevisiae needs to be engineered to express a heterologous xylose
pathway. However, it has been challenging to optimize the engineered
strain for efficient and rapid fermentation of xylose. Deletion of PHO13
(pho13) has been reported to be a crucial genetic perturbation for
improving xylose fermentation. A confirmed mechanism of the
pho13-positive effect on xylose fermentation is that the deletion of
PHO13 transcriptionally activates the genes in the non-oxidative pentose
phosphate pathway (PPP). In the present study, we reported that a
pho13-positive effect was not observed from a couple of engineered
strains, among the many others we have examined. To extend our knowledge
of pho13-mediated metabolic regulation, we performed genome sequencing
of pho13-negative strains. We identified a loss-of-function mutation in
GCR2 responsible for the pho13-negative phenotype. Gcr2 is a
transcriptional activator of the lower glycolytic pathway. Thus, the
deletion of GCR2 (gcr2) led to deactivation of lower glycolysis as
confirmed by RNA-seq. Also, gcr2 resulted in the up-regulation of PPP
genes, which explains the improved xylose fermentation of gcr2 mutants.
As pho13 and gcr2 cause similar transcriptional changes with PPP genes,
there was no synergistic effect between pho13 and gcr2 for improving
xylose fermentation. The present study identified GCR2 as a new knockout
target to improve xylose fermentation and cellulosic biofuel production.
Now published in Frontiers in Bioengineering and
Biotechnology doi:
10.3389/fbioe.2021.654177
Fredholm and Volterra nonlinear possibilistic integral equations
Authors: Gal Sorin G. , Iancu Ionut T. 
Published: March 2021

Fredholm and Volterra nonlinear possibilistic integral equations	In this paper we study the nonlinear functional equations obtained from the classical integral equations of Fredholm and of Volterra of second kind, by replacing there the linear Lebesgue integral with the nonlinear possibilistic integral.
Clea Gerber, La genealogía en cuestión: cuerpos, textos y reproducción en el ‘Quijote’ de Cervantes, Alcalá de Henares, Universidad de Alcalá, Instituto Universitario de Investigación Miguel de Cervantes, 2018, 316 pp.
Authors: Fonsalido María Elena 
Published: March 2021

Revisión del libro La genealogía en cuestión: cuerpos, textos y reproducción en el ‘Quijote’ de Cervantes de Clea Gerber
Efficiency of mesenchymal stromal cells (MSCs) in the treatment of patients with critical limb-threatening ischemia
Authors: Vavilov V. N. , Zaritskey A. Yu. , Polyntsev D. G. , Kurianov P. S. , Krutikov A. N. , Zenkova H. A. , Shiritova F. Z. 
Published: March 2021

Relevance. The relevance of the study is determined by the fact that hopes are placed in the cell therapy for patients with critical limb-threatening (CLI) ischemia as a method of the restoration of blood circulation in the affected limb in patients who cannot undergo surgical or endovascular intervention. Aim. To evaluate the efficiency of allogeneic MSCs for the treatment of critical lower limb ischemia (randomized placebo-controlled study).Materials and methods. The study included 34 patients with critical lower limb ischemia (grade 4 according to Pokrovsky). There were 18 patients in the MSC group, and 16 patients in the placebo group). The groups were comparable concerning age, disease duration, and comorbidities. Allogeneic MSCs (phenotype CD73+, CD90+, CD105+, CD45–, CD34–, CD14–) were injected into the posterior calf muscles. Clinical outcome, ankle pressure, transcutaneous oxygen tension (tcpO2), and pain-free walking distance (PFWD) were evaluated. The patients were followed-up for 12–36 months. According to the clinical outcome in each group, the patients were divided into subgroups with «effect (+)» or «effect (–)». In 2 patients, there was an «uncertain clinical outcome». When analyzing the results, these patients were assigned to one or another subgroup.Results. In the MSC and placebo groups, the clinical outcome assessed as «effect (+)» or «effect (–)» did not differ (OR 1.5; 95 % CI 0.34–6.7). With different variants of group formation and with the assignment of patients with an «uncertain clinical outcome» to a one or another subgroup, the final results neither differed. According to instrumental research methods (PFWD, tcpO2, ankle pressure, angiography), there were no differences in the MSC and placebo groups. Conclusion. With different variants of analysis and group formation, no convincing evidence that allogeneic MSCs can be effective for the treatment of critical lower limb ischemia have been obtained.
The structure of the relationship between indicators of aerobic performance, central hemodynamics, microcirculation and hemorheology
Authors: Mikhaylov P. V. , Muravyov A. V. , Osetrov I. A. , Ostroumov R S. , Tikhomirova I. A. 
Published: March 2021

Introduction. In physiological research, an important task is to find the relationship between the various functional parameters of the organism, its individual systems and its elements. These relationships can be complex, mediated by additional factors and when using pair correlation, they cannot be detected. In this case, it seems justified to use factor analysis to search for the hidden structure of relationships between many variables. The aim. Factor analysis of a set of data, including indicators of aerobic performance, central hemodynamics, microcirculation (MC) and hemorheology.Materials and methods. The study involved 172 men aged 20 to 60 years. Physical performance was determined using the PWC170 test. Microcirculation parameters were determined using biomicroscopy and Laser Doppler Imaging (LDI). The complex of hemorheological characteristics included the viscosity of blood and plasma, aggregation and deformability of erythrocytes. Statistical processing, including factor analysis, was carried out using the Statistica 6.0 software package. The factorial model included 32 parameters. When interpreting the results of factor analysis, variables with factor loadings of more than 0.60 were considered.Results. Three factors were identified, which accounted for 71 % of the total variance. The first factor closely correlated with the level of the body’s aerobic performance parameters and its adaptive potential. The second factor correlated with hemodynamic parameters at the central and microcirculatory level, including integral rheological parameters. The third factor correlated with the parameters of microvessels and the rheological properties of erythrocytes.Conclusions. The constructed factor model demonstrates the level structure of the relationships of indicators of aerobic performance, central hemodynamics, microcirculation, and hemorheology. The selected factors – the hidden elements of this structure linking individual variables – were interpreted as levels of integration: organismic, systemic and microlevel.
Vulnerabilidade e as violências mais comuns enfrentadas pelas mulheres brasileiras
Authors: Tinoco Nayandra da Silva , Dos Santos Adriene Roberta Costa , Fialho Salinny da Silva Ferreira , Redman Raquel De Souza , Lima Alaine Naielly da Silva , Dos Santos Janeide de Souza , Rocha Suellen Karine da Silva , Costa Cheila Aparecida Almenares , Serrão Dablina Jasmine Farias Colares , Figueiredo Silvana Nunes 
Published: March 2021

Objetivo: Identificar quais são as vulnerabilidades das mulheres brasileiras e sua relação com os tipos mais comuns de violência. Métodos: Trata-se de um estudo descritivo exploratório onde optou-se por métodos de Revisão Integrativa de Literatura (RIL). A busca por publicações cientificas foi realizada de abril de 2019 a outubro de 2020, utilizando-se bibliotecas virtuais: Biblioteca Virtual em Saúde (BVS), LILACS e Scientific Electronic Library Online (SCIELO). Resultados: A maior parte dos artigos utilizados é de 2018, a faixa etária manteve-se diversificada e a maioria das mulheres eram pretas ou pardas, casadas e com baixo nível de escolaridade, os tipos de violência mais comuns foram a violência psicológica seguida da física, o principal agressor costuma ser o parceiro íntimo e o local de ocorrência da violência costuma ser a residência da vítima. Considerações finais: Portanto, é observado que quando as mulheres são pretas ou pardas e com baixo nível escolar as chances de serem vítimas aumenta, o que mostra a necessidade de se conhecer o perfil da mulher que sofre violência.
Tubular laminectomy and percutaneous vertebroplasty for aggressive vertebral hemangioma
Authors: Papadakos Dimitrios , Boulieris Spiros , Theofanopoulos Andreas , Fermeli Dionysia , Constantoyannis Constantine 
Published: March 2021

Background:
Vertebral hemangiomas (VH) are the most common benign vascular neoplasms of the spine. Aggressive VH (AVH) may become symptomatic due to soft-tissue expansion/extraosseous extension into the paraspinal and/or epidural spaces. There are several options for treating painful AVH, including radiotherapy and/or open surgery.

Case Description:
A 59-year-old male presented with a 2-year history of intermittent back pain and progressive thoracic myelopathy in the past 2 months. MRI revealed a T9 level lesion, with high-intensity signal on both T1 and T2 images and an extraosseous component with significant cord compression. We performed minimally invasive tubular unilateral laminotomy for bilateral decompression of the thoracic spine at the T9 level, followed by bilateral percutaneous vertebroplasty with biopsy. Postoperatively, the pain was immediately relieved, and the myelopathy improved. The biopsy confirmed the diagnosis of a VH.

Conclusion:
Combining minimally invasive techniques consisting of tubular laminectomy and percutaneous vertebroplasty are safe and effective ways for treating AVHs.
Role of Value Added and Conventional Accounting Measures in Stimulating Stock Market Returns: A Study of Non-Financial Sector Listed at Pakistan Stock Exchange
Authors: Nosheen Rasool  , Safi Ullah  , Muhammad Mubashir Hussain  , Muhammad Usman  
Published: March 2021

The purpose of this study is to examine the comparative relationship of value-added and conventional financial performance indicators with stock returns of listed companies of Pakistan Stock Exchange. Stock Return (SR) is used as an outcome variable, whereas, for measuring explanatory variables, Traditional Financial Performance indicators includes return on assets (ROA), return on equity (ROE), Return on Capital Employed (ROCE) and Earnings Per Share (EPS) whereas modern performance indicators is measured through economic value added (EVA), economic value added movement (EVAM), economic value added spread (EVAS). The sample consists of 107 companies and having 856 observations of non-financial sector listed on Pakistan Stock Exchange (PSX) for the time period 2011 to 2018. Findings reveal that stock returns are more influenced by the value that is created by listed companies for their shareholders than the accounting profits. The study aims at providing useful information for the management, investors, researchers, and regulators.
PENINGKATAN KINERJA UKM BATIK MELALUI KUALITAS ASET STRATEJIK
Authors: Wibowo Bagus Yunianto 
Published: March 2021

The purpose of this study was to examine the effect of entrepreneurial orientation and organizational learning on the quality of strategic assets, and also the effect of strategic asset quality on business performance. This research was conducted at UKM Batik Semarang, the respondents used were 102 respondents. The data is processed using Structural Equation Modeling (SEM) with the help of the Analysis of Moment Structure (AMOS) version 18.0 program.
Based on the results of the analysis, it is concluded that the effect of entrepreneurial orientation on the quality of strategic assets shows a CR value of -0.338 and with a probability of 0.735, testing the effect of entrepreneurial orientation on business performance shows a CR value of 2.499 and with a probability of 0.012, testing organizational learning on strategic asset quality shows a value CR is 4.881 and with a probability of 0.001., Testing the effect of organizational learning on business performance shows a CR value of 1.351 and with a probability of 0.177, the effect of strategic asset quality on business performance shows a CR value of 2.067 and with a probability of 0.039.

Keywords: Entrepreneurship Orientation, Organizational Learning, Strategic Asset Quality, Business Performance
PENGARUH WEBSITE QUALITY DAN E-SERVICE QUALITY TERHADAP E-LOYALTY DENGAN VARIABEL INTERVENING USER SATISFACTION PADA MAHASISWA FE UST YOGYAKARTA PENGGUNA SHOPEE
Authors: Deviana Sherlyn 
Published: March 2021

Decision The purpose of this study was to examine the effect of the website on Shopee and service quality at Shopee on customer loyalty. The sampling technique in this study used a questionnaire distribution technique. And the object in this study is Shopee users (students) at the Faculty of Economics, University of Sarjanawiyata Tamansiswa Yogyakarta with a sample size of 100 respondents. This object is a Shopee user who accidentally meets the researcher and the object is in accordance with the researchers' criteria to be used as a data source.
The data obtained were then analyzed using the SPSS version 22 software application. The test was carried out with a hypothesis to determine whether there was an effect of variable X1 and variable X2 on variable Y with the intervening variable User Satisfaction. The results of this study prove that Website Quality and E-Service Quality on E-Loyalty through User Satisfaction in FE students at UST Yogyakarta, shopee customers and E-Service Quality have a positive effect on E-Loyalty is rejected.
KINERJA PEMASARAN DITINJAU DARI INOVASI PRODUK , LINGKUNGAN DAN ORIENTASI PASAR (Studi Kasus UMKM Kuliner yang Terdaftar di Rumah BUMN Solo)
Authors: Lestari Sri 
Published: March 2021

Abstrak
Tujuan diadakannya penelitian ini adalah untuk meganalisis pengaruh dari variabel inovasi produk, lingkungan dan orientasi pasar secara simultan maupun parsial terhadap kinerja pemasaran UMKM Kuliner yang terdaftar di Rumah BUMN Solo. Jenis penelitian ini merupakan penelitian menggunakan analisis kuantitatif yang mengambil sampel 40 orang pemilik UMKM Kuliner yang terdaftar di Rumah BUMN Solo. Teknik pengumpulan data pada penelitianpini menggunakan kuesioner dengan skala likert. Analisis data dalam ppenelitian ini menggunakan teknik analisis regresi linier berganda. Hasil dalam penelitian ini menunjukkan bahwa variabel inovasi produk tidak berpengaruh dan signifikan terhadap kinerja pemasaran. Lingkungan berpengaruh tidak signifikan terhadap kinerja pemasaran. Orientasi pasar berpengaruh signifikan terhadap kinerja pemasaran. Hasil uji R2 menunjukkan inovasi produk, lingkungan dan orientasi pasar memberikan kontribusi 36,6% terhadap kinerja pemasaran UMKM Kuliner yang terdaftar di Rumah BUMN Solo.

Kata kunci: Inovasi Produk, Lingkungan, Orientasi Pasar dan Kinerja Pemasaran.
PENGARUH RASIO LIKUIDITAS, LEVERAGE, DAN SALES GROWTH TRHADAP FINANCIAL DISTRESS PADA PERUSAHAAN PROPERTY DAN REAL ESTATE YANG TERDAFTAR DI BEI
Authors: Susanti Irma 
Published: March 2021

Financial distress is a stage of decline in financial conditions that occurs before bankruptcy occurs. This study aims to examine the effect of liquidity, leverage, and sales growth on financial distress in property and real estate companies listed on the Indonesia Stock Exchange (IDX). The population in this study were all property and real estate companies listed on the Indonesia Stock Exchange for the period 2015-2019. The sample was selected based on the purposive sampling method, in order to obtain a sample of 24 companies. The data analysis technique used is logistic regression analysis, with data processing using the SPSS program. The results showed that (1) liquidity as measured by (CR) had a positive and insignificant effect on financial distress; (2) leverage as measured by (DER) has a negative and insignificant effect on financial distress; and (3) Sales Growth as measured by (GROWTH) has a positive and insignificant effect on financial distress.
Keyword: Liquiditys, Leverae, Sales Growth, Financial Distress
Cenas discursivas da pandemia de Covid-19: o discurso sobre o isolamento social na imprensa
Authors: Alves Wedencley , Pimenta Denise Nacif , Antunes Michele Nacif 
Published: March 2021

O presente artigo tem como objetivo analisar discursos do/no jornal O Globo, um veículo de referência no jornalismo brasileiro, sobre a estratégia de isolamento social como forma de contenção da pandemia de Covid-19. Para isso, tomou como base de observação e análise notícias e reportagens publicadas pelo jornal durante as duas primeiras semanas de medidas (do dia 16 ao dia 26 do mês de março de 2020). O estudo partiu da Análise de Discurso (Pêcheux/Orlandi) para compreender se houve deslocamentos de sentido em relação às medidas e aos embates discursivos que tiveram lugar entre autoridades políticas, de saúde e a própria população. O artigo conclui que mais do que produzir sentido sobre a cena discursiva que se instaurou durante esse período, o próprio jornal se fez ator nessa cena, participando de intrigas discursivas que nela tiveram lugar.
Uji Coba Pembuatan dan Strategi Pemasaran Dodol Berbahan Dasar Labu Siam
Authors: Andriani Dewi , Achmadi Nila Sartika , Ramadhani Andi Azizah 
Published: March 2021

<p align="center"><strong><em>ABSTRACT</em></strong></p><p><strong><em> </em></strong></p><p><em> Chayote is a local vegetable with high nutrient which is sold with low price. Chayote can be produced into dodol with the following steps: sorting, peeling, cutting, washing, mashing, and then processing chayote into dodol. This research aims to find out how to measure people’s acceptance of chayote dodol and how to market it. This is an experimental research on how to make chayote dodol and descriptive research to describe the best marketing strategy to introduce chayote in the market. The population is students of Bosowa Polytechnic where 73 of them were chosen to become the sample to test the taste, color, scent, and texture of chayote dodol. There were three treatments: LS1 (100% chayote), LS2 (75% chayote), and L3 (50% chayote). Data was analyzed with descriptive statistic from Hedonic Test. The highest average score from the scent treatment was LS1 with 3.31 out of 5 score. From the taste, the respondents mostly chose LS1 with 2.88 average score. From the color, the respondents mostly chose LS2 with average score of 3.01. The last aspect was texture and mostly respondents chose LS1 with 3.00 average score. Based on the result, this research used 4Ps marketing strategy to introduce this product to the market.</em></p><p><strong><em>Keywords: </em></strong><em> </em><em>dodol, chayote, hedonic test, marketing strategy</em></p>
STRATEGI PENGEMBANGAN BISNIS BERBASIS MENU ENGINEERING DI KAMBING SOON RESTO AND CAFE BANDUNG
Authors: Ardiansyah Imam , Magdalena Vania 
Published: March 2021

<p align="center"><strong><em>ABSTRACT</em></strong></p><p align="center"><strong> </strong></p><p><em> Bandung city is a tourist destination city that has a choice of various culinary both traditional and international. One of the Resto and Cafe in Bandung is Kambing Soon Resto and Cafe located at Jl. IR H Djuanda. One of the factors that become the main force for business in the field of this restaurant is the menu, even the menu can also be the identity of the restaurant terebut. A good menu can be seen from the level of sales and ability to provide benefits or the level of popularity and profitability. Based on these conditions, the researcher aims to analyze the engineering menu, the research was conducted in August 2017 until November 2017. The method used is the analysis of margin contribution and analysis of popularity index, menu classification, and SWOT analysis.Based on the analysis for 4 months, the results obtained are 32 food menu that the researcher carefully is the category of stars consists of 7 menus with percentage of 21.88%, plowhorses category consists of 11 menus with percentage of 34.37%, the category consists of puzzles 4 menus with percentage of 12.50%, dogs category consists of 10 menus with a percentage of 31.25%.</em></p><p><em>Keywords: Menu Engineering, Business Development</em></p>
Penelitian Produk: Inovasi Pembuatan Cheese Cake Menggunakan Bahan Kacang Panjang Sebagai Pengganti Tepung Terigu
Authors: Yuliantoro Nonot 
Published: March 2021

<p align="center"><strong><em>ABSTRACT</em></strong></p><p><strong><em> </em></strong></p><p><em>Making cheesecake using long bean is one of the latest innovations in making cheese cake that has never been seen before. Cheesecake generally use flour, this study aims at how long bean can be used as a component of chiffon cheesecake by drying and processing into vegetabel flour. This research was conducted to find out whether vegetabel flour can affect the texture, taste, aroma and color of cheesecake. The purpose of long bean as a substitute for wheat flour is for consumption for the general public, especially for those who cannot consume gluten and make an alternative for people who do not like vegetabels. In this study, we have conducted several vegetabel group studies ranging from vegetabel, leaf, stem, flower and fruit groups. Then found the right vegetabel group to be made as a component of cheesecake, namely fruit vegetabels. In addition, modifications are also made to the recipe, especially on the amount of vegetabel flour. Excessive amounts will greatly affect the taste, texture, and aroma of the cheesecake. This study uses the homemade method. Homemade, which is meant by itself, is the making of using equipment that is few and can be made by anyone with the right technique.</em></p><p><strong><em>Keyword: Cheese cake, long bean, homemade</em></strong></p><p align="center"> </p><p align="center"><strong> </strong></p><p align="center"><strong>ABSTRAK</strong></p><p><strong> </strong></p><p>Pembuatan cheesecake dengan menggunakan kacang panjang merupakan salah satu inovasi terbaru pembuatan cheesecake. Chiffon Cheesecake pada umumnya menggunakan tepung terigu, Penelitian ini menggunakan sayuran kacang panjang sebagai bahan pengganti tepung terigu dengan cara mengeringkan kacang panjang dan di olah menjadi tepung sayuran. Tujuan penelitian untuk mengetahui apakah tepung sayuran bisa mempengaruhi tekstur, rasa, aroma dan warna pada cheesecake. Pemilihan Sayuran sebagai pengganti tepung terigu adalah alternative pengganti bagi mereka yang tidak bisa mengkonsumsi gluten serta menjadikan alternatif bagi orang-orang yang tidak menyukai sayuran. Di dalam penelitian ini, dilakukan percobaan pembuatan cheesecake dengan bahan berbagai golongan sayuran. Kemudian ditemukan golongan sayuran yang tepat untuk di jadikan komponen cheesecake yaitu sayuran buah. Selain itu, dilakukan juga modifikasi pada resep terutama pada jumlah tepung sayuran. Jumlah yang berlebihan akan sangat mempengaruhi rasa, tekstur, dan aroma pada cheesecake. Dalam melakukan uji coba produk dilakukan dengan cara homemade.</p><p><strong>Kata kunci: Cheese Cake, kacang panjang, homemade</strong>.<strong><em></em></strong></p>