bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Nutritional Risk in the Acute Care Setting: Progress Towards a Practice and Evidence Informed Systems Level Approach
Authors: Chamberlain Diane , Doeltgen Sebastian , Knowles Reegan , Yaxley Alison , Miller Michelle 
Published: August 2021

Abstract
BackgroundTo improve nutritional assessment and care pathways in the acute care setting, it is important to understand the indicators that may predict nutritional risk. Informed by a review of systematic reviews, this project engaged stakeholders to prioritise and reach consensus on a list of evidence based and clinically contextualised indicators for identifying malnutrition risk in the acute care setting. MethodsA modified Delphi approach was employed which consisted of four rounds of consultation with 54 stakeholders and 10 experts to reach consensus and refine a list of 57 risk indicators identified from a review of systematic reviews. Weighted mean and variance scores for each indicator were evaluated. Consistency was tested with intra class correlation coefficient. Cronbach's alpha was used to determine the reliability of the indicators. The final list of indicators was subject to Cronbach’s alpha and exploratory principal component analysis. ResultsFifteen indicators were considered to be the most important in identifying nutritional risk. There was 82% agreement for the final 15 indicators that they collectively would predict malnutrition risk in hospital inpatients. Conclusion The 15 indicators identified are supported by evidence and are clinically informed. This represents an opportunity for translation into a novel and automated systems level approach for identifying malnutrition risk in the acute care setting.
All-Fiber Optical Nonreciprocity Based on Parity-Time-Symmetric Fabry-Perot Resonators
Authors: Li Zheng , Zhang Jiejun , Zhi Yanyan , Li Lingzhi , Liao Baoliang , Yao Jianping 
Published: August 2021

Abstract
Nonreciprocal light transmission in an all-fiber device with remotely tunable isolation ratio and switchable isolation direction is proposed and demonstrated. Three cascaded fiber Bragg gratings (FBGs) are inscribed in an erbium-ytterbium co-doped fiber (EYDF) to form two mutually coupled Fabry-Perot (FP) resonators. The two FP resonators have an identical geometry, but the gain and loss of the FP resonators, and their mutual coupling are manipulated by controlling the pumping power to realize broken parity-time (PT) symmetry. Strong optical nonreciprocity is achieved due to gain saturation nonlinearity that is enhanced by the broken PT symmetry. The proposed device is fabricated, and its operation is experimentally evaluated. Nonreciprocal light transmission with an isolation ratio of 8.58 dB at 1550 nm and a 3-dB bandwidth of 125 MHz is experimentally demonstrated. Our study also indicates, by optimizing the design, an isolation ratio up to 33 dB can be achieved. The proposed approach provides an all-fiber solution for a remotely tunable and optically controlled isolator, which may find great applications in software-defined optical networks.
The Identity and Distribution of Striped Bagrid Catfish, Mystus Tengara (Hamilton 1822) Revealed Through Integrative Taxonomy
Authors: Nair Sangeetha , Kumari Kavita , Kumar Pavan , Raghavan Rajeev , Jaiswar Ashok 
Published: August 2021

Abstract
In the present study, an integrated taxonomic approach has been applied to clarify the taxonomic status, identity and distribution of bagrid catfish, Mystus tengara. Comparative morphometric evaluation of M. tengara identified in the present study from distant geographical location revealed variations of the traits in response to body length and environment, without significant genetic distance. The observed morphometric traits of M. tengara were found to be overlapping with available morphometric traits of M. tengara, M. carcio and M. vittatus. Maximum likelihood phylogenetic analysis based on mitochondrial cytochrome c oxidase (COI) gene also could not resolve their identity, and five paraphyletic clades comprising of M. tengara, M. vittatus and M. carcio from India, Nepal and Bangladeshwere observed. Morphological and genetic evidence along withcomparative evaluation of M. tengara, from its type locality, we consider M. tengara identified in the present study to be true, with its distribution extending from North East India to West Bengal, North India, Central India, Northern peninsular India and Bangladesh. The observation of paraphyletic subclade and evaluation of genetic distance between subclades reveals, there could be at least four cryptic species in this group. Further confirmation on the identity of M. vittatus and M. carcio, by integrated taxonomic approach based on fresh specimens collected from type locality, is required.
Stressful Events and Oral Health Related Quality of Life Aboard: a Longitudinal Study
Authors: Carlos Juliana Cristina , Leão Anna Thereza Thomé , Penoni Daniela Cia 
Published: August 2021

Abstract
Background: Stressful events may affect self-perceived general and oral health. While the working environment is known to expose military personnel to chronic stress, oral health reports in these populations is limited. Methods: This longitudinal study aimed to investigate the association of oral health related quality of life (OHRQL) and stress in the military population aboard a training ship for 6 months. The participants included were 259 crew and 227 cadets. Two anonymous questionnaires, the perceived stress scale (PSS-14) and the oral health impact profile (OHIP-14), were applied at baseline and follow-up (six-month later). Socio-demographic characteristics were also obtained. Results: Multivariate Poisson regression analysis showed that PSS-14 predicted higher OHIP-14 scores at baseline and follow-up. At follow-up, besides PSS-14 (RR: 2.03; 1.42-2.90), being part of the crew group represented an increase of 87% on the OHIP-14 scores (RR:1.87; 1.27-2.74). Older individuals were 24% less likely to present higher OHIP-14 scores (RR:0.76; 0.58-0.99) than younger ones. Conclusion: Oral health related quality of life has worsened over time in this military population, and stress was an associated factor of that. Trial registration: 10751419.8.0000.5256/2019.
Clinical Application of Foldable Capsular Vitreous Bodies in the Treatment of Severe Ocular Trauma and Silicone Oil Dependent Eyes
Authors: Jiang Hao , Xue Chao , Gao Yanlin , Chen Ying , Wang Yan 
Published: August 2021

Abstract
Background: Recently, a new type of foldable capsular vitreous body (FCVB) has been developed for clinical application to fill the vitreous cavity with vitreous substitutes. It may be an ideal substitute for the vitreous body in eyes with severe retinal detachment. The aim of this study was to assess the application of a foldable capsular vitreous body (FCVB) in the treatment of severe ocular trauma and silicone oil (SO) dependent eyes.Methods: A retrospective analysis was performed on the clinical application of FCVB in the treatment of severe ocular trauma and SO dependent eyes. The results of best-corrected visual acuity and intraocular pressure (IOP) evaluation, B-scan ultrasonography or color Doppler ultrasonography, ultrasound biomicroscopy, and anterior segment photography were recorded during follow-up. A paired t-test was used to compare the difference in IOP before and after FCVB implantation. Results: Seven eyes of seven patients were included in the 6 months follow-up. In all cases, B-scan ultrasonography and ultrasound biomicroscopy showed that FCVB adapted closely to the globe wall and ciliary body, thus supporting the retina. Visual acuity did not improve, except in one case from LP to HM. The mean±SD IOP was 9.29±1.60mmHg prior to FCVB implantation and 10.43±0.98mmHg after implantation, with no significant difference between these measurements (P=0.066). Five of the seven patients developed differing degrees of corneal opacity and keratopathy. Conclusions: FCVB implantation may be a safe and effective method for the treatment of severe ocular trauma and SO dependent eyes. However, corneal opacity and keratopathy are potential serious complications after surgery. Appropriate case selection and proper surgical time require further investigation.
Assessment of the Knowledge of CT Scanner Operators on the Use of Dose Reduction Software Called Automatic Exposure Control (AEC) During a CT Scan
Authors: Kamdem Eddy Fotso , Samba Odette Ngano , Abogo Serge , Tambe Joshua , Amougou Jean Claude Mballa , Guegang Emilienne , Zeh Odile Fernande , Nguemgne Célestine , Nwedjiwe Narcisse Fidèle Nana , Fotue Alain Jervé 
Published: August 2021

Abstract
Objectif : Evaluate the knowledge of medical imaging technicians on the use of dose reduction software and the concept of patient radiation protection.Materials and methods : Descriptive and analytical transversal study from January 1 to December 1, 2020, conducted in the radiology and medical imaging services of Cameroon's public and private hospitals with a CT scanner. It was the first study on this topic that was conducted in Cameroon. This study was conducted from a questionnaire distributed to all medical imaging technicians in 10 country hospitals relating to the notions of dose reduction software and patient radiation protection.Results: 80 questionnaires were distributed and analyzed. The average age of medical imaging technicians was 30 years old. There were 32 women and 48 men. Most of the medical imaging technicians worked in private centers (n = 6). 75% of medical imaging technicians had been in practice for more than 5 years. 75% of medical imaging technicians gave the wrong answer regarding the use of dose reduction software. Finally, only a third of the practitioners had received training in patient radiation protection.Conclusion : Although the majority of medical imaging technicians declares to take into account the dangers related to ionizing radiation during examinations, a broader dissemination of patient radiation protection training and the use of dose reduction software, particularly during the initial curriculum. Radiology technicians could be one of the solutions to improve the knowledge of hospital practitioners in patient radiation protection. However, the use of ionizing radiation, however, need to know and take into account the potential risks of radio-induced cancer linked to high X-ray doses.
Development of Optimized Protocol for Culturing African Swine Fever Virus (ASFV) Field Isolates in MA104 Cells
Authors: Kwon Hyeok-il , DO DUY tien , Vo Hung Van , Lee Seung-Chul , kim Min-Ho , Nguyen Dung Thi Thuy , Tran Tan Minh , Le Quang Tin Vinh , Ngo Tram Thi , Nguyen Nam Minh , Lee Joo Young , Nguyen Toan Tat 
Published: August 2021

Abstract
I. Background: ASFV causes a highly contagious hemorrhagic disease with a high mortality rates in domestic pigs. The virus has been isolated across various cell lines, but identifying a cell line to develop an effective commercial vaccine has been challenging which a major obstacle to effective vaccine development is identifying a commercial cell line that is suitable for high-yield viral replication.II. Methods and Results: The goal of this study was to identify a candidate commercial cell line for the replication of African swine fever virus (ASFV) by comparing several available cell lines with various medium factors. In the sensitivity test of cells, MA104 and MARC-145 had strong potential for ASFV replication. Next, MA104 cells were used to compare the adaptation of ASFV obtained from tissue homogenates and blood samples in various infectious media. At the 10th passage, the ASFV obtained from the blood sample had a significantly higher viral load than that obtained from the tissue sample (P = 0.000), exhibiting a mean Ct value = 20.39 ± 1.99 compared with 25.36 ± 2.11. For blood samples, ASFV grew on infectious medium B more robustly than on infectious medium A (P = 0.006), corresponding to a Ct value = 19.58 ± 2.10 versus 21.20 ± 1.47. ASFV originating from blood specimens continued to multiply gradually and peaked in the 15th passage, exhibiting a Ct value = 14.36 ± 0.22 in infectious medium B and a Ct value = 15.42 ± 0.14 in infectious medium A. However, there was no difference (P = 0.062) in ASFV growth between infectious media A and B when ASFV was cultured from tissue homogenates. III. Conclusions: A model was developed to enhance ASFV replication through adaptation to MA104 cells and the lack of mutation in serial culture passages may serve to maintain the immunogenicity of ASFV isolates when they are developed as vaccine candidates.
Successful Treatment of a Spinal Clear Cell Meningiomas Patient With Anti-PD-1 Plus Anti- Angiogenesis
Authors: Wang Yong , Liu Baoyan , Tao Rongjie , Qi Yingxue , Luo Ningning , Gao Yongsheng , Yuan Shuanghu 
Published: August 2021

Abstract
Clear cell meningioma (CCM), an unusual subtype of World Health Organization (WHO) grade II meningioma, represents only 0.2– 0.8% of meningiomas. Spinal CCMs are even rarer with unique clinical features: more common in younger patients; more likely to appear in lumbar spine; high recurrence rate. Although surgery and radiotherapy are the most common treatment for primary tumors and disease recurrence, there are lack of treatment options for recurrent or metastasis disease. It is urgent need to explore new effective treatment method. In our case, we firstly reported a rare spinal CCM patient with PD-L1 positive and multiple metastases benefiting from PD-1 inhibitor plus anti- angiogenesis therapy. This treatment program is effective, safe, and has a strong therapeutic reference value, which provides promising treatment options and the direction of future clinical trials for spinal CCMs.
Skip-YOLO: Domestic Garbage Detection Using Deep Learning Method in Complex Multi-scenes
Authors: Zhao Lun , Pan Yunlong , Wang Sen , Zhang Liang , Islam Md Shafiqul 
Published: August 2021

Abstract
In In the field of garbage intelligent identification, similar garbage are difficult to be effectively detected due to different kinds of characteristics. This paper proposes a Skip-YOLO model for garbage detection in real life through the visual analysis of feature mapping in different neural networks. First of all, the receptive field of the model is enlarged through the large-size convolution kernel, which enhanced the shallow information of images. Secondly, the high-dimensional feature mappings of garbage is extracted by dense convolutional blocks. The sensitivity of similar features in the same type of garbage is enhanced by strengthening the sharing of shallow low semantics and deep high semantics information. Finally, the multi-scale high-dimensional feature mappings is integrated and sent to the YOLO layer to predict the type and location of garbage. Experimental results show that compared with the YOLOv3, the overall detection precision is increased by 22.5%, and the average recall rate is increased by 18.6%. In qualitative comparison, it successfully detects domestic garbage in complex multi-scenes. In addition, our approach alleviates the overfitting problem of deep residual blocks. The application case of waste sorting production line is used to further highlight the model generalization performance of our method.
Z-Guggulsterone attenuates cognitive deficits and reduces amyloid-β levels in APPswe/PS1dE9 mice by inhibiting toll-like receptor 4 pathway
Authors: Liu Jing , Yang Yang , Guo Yane , Shang Yanchang , Zhou Bo , Fan Jiao , Wei Chao 
Published: August 2021

Abstract
Background

Accumulating evidence has indicated that inflammatory damage plays a vital role in the pathogenesis of Alzheimer’s disease (AD) and represents one of the therapeutic targets. Z-Guggulsterone (Z-GS) is an active component extracted from myrrh, which has been widely used as an anti-inflammatory agent. The present study was to investigate the anti-inflammatory and neuroprotective effects of Z-GS on the disease progression, as well as the underlying mechanisms in the transgenic mouse models of AD.
Methods

Using behavioral, histological, and biochemical methods, outcomes of Z-GS treatment on neuropathology and cognitive deficits were studied in the APPswe/PS1dE9 mice.
Results

We found that Z-GS treatment resulted in a dramatic improvement of learning and memory deficits, a significant decrease in cerebral amyloid-β (Aβ) levels and plaque burden, a marked alleviation in neuroinflammation, and a profound reduction in synaptic defects in the APPswe/PS1dE9 mice. Furthermore, amyloid precursor protein (APP) processing was strongly suppressed with Z-GS treatment by inhibiting beta-site APP cleaving enzyme 1 (BACE1) protein expression to produce Aβ in the APPswe/PS1dE9 mice. In addtion, Z-GS modulated anti-inflammatory pathway via decreasing phosphorylation of inhibitor of nuclear factor-kappa B alpha (IκBα) and p65, which was achieved by inhibiting the activation of TLR4.
Conclusions

Collectively, Our results demonstrate that Z-GS protects neurons against inflammatory damage in AD, and this neuroprotective property involves the TLR4/NF-κB signaling pathway.
Identification of Chemotherapeutic Dihydromyricetin With Enhanced Anti-tumor Activity and Biosafety for Muscle Invasive Bladder Cancer
Authors: Wang Zijian , Guo Zicheng , You Wenjie , Wang Wang , Zhou Fenfang , Zhang Renjie , He Zhiwen , Chen Hongbo , Wang Xinghuan 
Published: August 2021

Abstract
Background: Muscle invasive bladder cancer (MIBC) is one of the most common malignant diseases in elderly men, such as veterans. Postoperative chemotherapy plays a vital role in preventing recurrence and metastasis of MIBC. However, fewer of chemotherapeutic drugs with remarkable anti-tumor activity and biosafety are available for clinical treatment.Methods: In this work, a novel plant-derived drug, named as dihydromyricetin (DHM), was selected for postoperative chemotherapy of MIBC. The anti-tumor activity was evaluated using a series of in vitro tests, such as MTT assay, flow cytometry and western blot. Furthermore, a xenograft model of BALB/C57 nude mice was established to verify the good anti-tumor activity and biosafety of DHM in vivo. Results: DHM could effectively inhibit the proliferation, survival and migration of MIBC cell, and promote apoptosis (P<0.05). Cytotoxic macrophage polarization from M0 to M1 was promoted by DHM treatment, and the hub genes in cell cycle and apoptosis signaling pathways were differential expressed. We also found that DHM could reverse the epithelial-mesenchymal transition (EMT) of MIBC cell. The in vivo results revealed that intravenous injection of DHM with a dose of 20 mg/kg for 7 times could significantly suppress the in vivo tumorigenesis of MIBC (P<0.05), while triggered no obvious drug side effects. Conclusion: This work identified a novel chemotherapeutic DHM with remarkable anti-tumor activity and biosafety, which could serve as a promising alternative for postoperative chemotherapy of MIBC.
Gene Set Enrichment Analysis and Ingenuity Pathway Analysis to verify the impact on Wnt Signaling Pathway in Taodan Granules Treated Psoriasis
Authors: Luo Ying , Zhang Ying , Yin Shuang-yi , Luo Yue , Ding Xiao-jie , Ru Yi , Xing Meng , Fei Xiao-ya , Song Jian-kun , Zhang Hui-ping , Liu Tai-yi , Li Bin , Kuai Le 
Published: August 2021

Abstract
Background: Taodan granules (TDGs), traditional Chinese herbals, are effective in treating psoriasis. However, mechanisms of TDGs remain indistinct. The current study aims to indicate the molecular mechanisms of TDGs in treating psoriasis.Methods: Primarily, transcriptional profiling was applied to identify differentially expression genes (DEGs). The following was that we used Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) analysis for functional enrichment analysis. Eventually, RT-PCR was performed to validation. Results: The results revealed that TDGs could regulated the Wnt signaling pathway to ameliorate skin lesions of imiquimod (IMQ)-induced psoriatic mouse models. IPA core network associated with Wnt signaling pathways in TDGs for psoriasis was established. Thereinto zeste homolog (EZH) 2, CTNNB1, TP63, and WD repeat domain (WDR) 5 could be considered as upstream genes in the Wnt signaling pathway.Conclusions: The Wnt signaling pathway with these above upstream genes might be potential therapeutic targets of TDGs for psoriasis.
Investigating Changes in β-Adrenergic Gene Expression (ADRB1 and ADRB2) in Takotsubo (Stress) Cardiomyopathy Syndrome
Authors: Onrat Serap Tutgun , Dural İbrahim Ethem , Yalım Zafer , Onrat Ersel 
Published: August 2021

Abstract
Background:Takotsubo Cardiomyopathy (TC) is a rare disorder that is mostly caused by stress and is often misdiagnosed. We aimed to analyze Takotsubo Syndrome at the molecular level by using the Oxford Nanopore Minion Device and its protocol. Methods and Results: Ten patients who were previously diagnosed with Takotsubo Syndrome (increased after decrease in ejection fraction and without critical stenosis in coronary arteries) and 10 healthy individuals in the control group were included in our project. The mean age was 53±12.2 for the patient group and 52.4±9.9 for the control group, and the left ventricular ejection fraction was 50.3±11.5 for the patient group and 64.2±2.8 for the control group (p<0.05). Peripheral blood of patients and healthy individuals was taken and their DNA was obtained. By making long reads throughout the genome, the most studied regions responsible for b- adrenergic signaling pathways; The gene expression level of cardiac β-1 ADRB1(rs1801253-ENST00000369295.4), G>C, (Gly389Arg) and cardiac β-2 ADRB2 (rs1800888-ENSG00000169252), C>T, (Thr165Ile) adrenoceptors was investigated. As a result; no structural variation was detected leading to Takotsubo Cardiomyopathy. The results obtained from the bioinformatics analysis were also checked from the VarSome Tools and similar results were found.Conclusions: Many publications in TC susceptibility have that may lead to adrenergic pathway dysregulation, most studied adrenergic receptor genes in the similar literatures too. We searched for genetic variants in b1AR and b2AR genes in our study and however we could not find any variants in this study, we think larger numbers of cohort studies are needed.
Big Data Classification of Remote Sensing Image Based on Cloud Computing and Convolutional Neural Network
Authors: Wu Xiaobo 
Published: August 2021

Abstract
In recent years, with the continuous development of cloud computing and big data technology, information technology is penetrating all corners of enterprise development at a speed that ordinary people cannot imagine. Today's remote sensing image classification plays an important role in many applications. This article is based on cloud computing and convolutional neural network to study the remote sensing image big data classification. This article takes cloud computing technology and convolutional neural network technology as the technical points. First, it introduces cloud computing technology in more detail from the basic concepts, characteristics and classification of cloud computing, and then compares traditional methods from the selection of feature extraction methods and classifiers. The remote sensing image classification method is described, and finally the convolutional neural network model that needs to be applied in this research is explained. In the experiment, the features extracted by multiple pre-training networks are fused. Through the study of the three feature fusion methods, it is found that the classification accuracy rate has been further improved on the three data sets. The experimental results in this paper show that the remote sensing image big data classification method based on cloud computing and convolutional neural network has more than a little improvement in accuracy than the traditional remote sensing image classification method, and the accuracy rate has reached 86.3%.