bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of sarcoplasmic proteins oxidation on the gel properties of myofibrillar proteins from pork muscles
Authors: Feng Xiaolong , Wu Di , Yang Kun , Wang Limei , Wang Xian , Ma Jing , Zhang Yunhua , Wang Caili , Zhou Yuanhua , Sun Weiqing 
Published: April 2021

AbstractThis study investigated the influence of sarcoplasmic proteins (SPs) treated by the oxidation system (0.1 mmol/L FeCl3, 0.1 mmol/L ascorbic acid, and 0, 1, 5, 10 mmol/L H2O2) on the properties of pork myofibrillar proteins (MPs) gel. After oxidation treatment, the SPs showed an increased in carbonyl content and a decreased in total sulfhydryl content, coupled with the cross‐linking of protein components by disulfide bonds and covalent bonds. The MPs gel with SPs oxidized at 1 mmol/L H2O2 exhibited the maximal strength while the minimal water holding capacity (WHC). The WHC of MPs gel was significantly decreased with increasing SPs oxidation, leading to the increase of free water and the decrease of immobilized water in the gel system. The microstructures of MPs gels with moderately (1 mmol/L H2O2) oxidized SPs showed a more compact and smaller pore gel network than MPs alone, suggesting adding oxidized SPs can expel water trapped in the gel. Furthermore, the environmental polarity of aliphatic C‐H groups increased with SPs oxidation.
Prevention of docetaxel‐associated febrile neutropenia with primary granulocyte colony‐stimulating factor in Chinese metastatic hormone‐sensitive and castration‐resistant prostate cancer patients
Authors: Poon Darren M.C. , Chan Kuen , Chan Tim‐Wai , Ng Bryan , Siu Steven , Ng Joyce , Johnson David , Lee Ka Chai ,   Hong Kong Society of Uro‐Oncology (HKSUO)
Published: April 2021

AbstractIntroductionAsian prostate cancer (PC) patients are particularly susceptible to docetaxel‐related febrile neutropenia (FN). We evaluated primary granulocyte colony‐stimulating factor (GCSF) for preventing FN in Chinese patients with metastatic hormone‐sensitive PC (mHSPC) and castration‐resistant PC (mCRPC).Patients and MethodsData from two cohorts of 377 Chinese patients with mHSPC (100; 26.5%) and mCRPC (277; 73.5%) treated with docetaxel at six public oncology centres were analysed with multivariate regression. Primary GCSF prophylaxis was defined as administration within 5 days of starting docetaxel. The primary outcome was FN within 21 days of the first docetaxel cycle (1st FN).ResultsPrimary GCSF was given to 71 (18.8%) patients. FN occurred in 61 patients (16.2%) including 37 (9.8%) during the first cycle. Among patients who developed 1st cycle FN (n = 37) or not (n = 340), 2 and 69 received primary GCSF (5.4 vs. 20.3%, P = .03). Primary GCSF was associated with an overall reduced risk of 1st cycle FN (odds ratio [OR] = 0.22; 95% confidence interval [CI]: 0.05‐0.96, P = .04), and similar trends were observed in the mHSPC (OR = 0.36, P = .35) and mCRPC (OR = 0.16, P = .08) subgroups. Poor Eastern Cooperative Oncology Group performance status (>1) was associated with an increased risk of 1st FN (OR = 3.90; 95% CI: 1.66‐9.13, P = .002).ConclusionsTo alleviate the risk of docetaxel‐related FN, primary GCSF prophylaxis is suggested for Asian mCRPC and mHSPC patients, particularly those with poor performance status.
Hong Kong Urological Association–Hong Kong Society of Uro‐Oncology consensus statements on the management of advanced prostate cancer—2019 Updates
Authors: Poon Darren Ming‐Chun , Chan Chi‐Kwok , Chan Tim‐Wai , Cheung Foon‐Yiu , Ho Lap‐Yin , Kwong Philip Wai‐Kay , Lee Eric Ka‐Chai , Leung Angus Kwong‐Chuen , Leung Simon Yiu‐Lam , So Hing‐Shing , Tam Po‐Chor , Ma Wai‐Kit 
Published: April 2021

AbstractBackgroundTo update the Hong Kong Urological Association–Hong Kong Society of Uro‐Oncology consensus statements on the management of advanced prostate cancer, the same panelists as in the previous consensus panel held a series of meetings to discuss updated clinical evidence and experiences.MethodsThe previous consensus statements were retained, deleted, or revised, and new statements were added. At the final meeting, all statements were reviewed and amended as appropriate, followed by panel voting.ResultsThere were significant changes and additions to the previous consensus statements, primarily driven by the advances in androgen receptor signaling inhibitors, treatment sequencing in metastatic castration‐resistant prostate cancer, and increasing recognition of oligometastatic prostate cancer since the introduction of prostate‐specific membrane antigen positron emission tomography. In this update, a total of 59 consensus statements were accepted and established.ConclusionsThe consensus panel updated consensus statements on the management of advanced prostate cancer, aiming to allow physicians in the region to keep abreast of the recent evidence on optimal clinical practices.
Association between retinal thickness variation and visual acuity change in neovascular age‐related macular degeneration
Authors: Cheong Kai Xiong , Teo Alvin Wei Jun , Cheung Chui Ming Gemmy , Too Issac Horng Khit , Chakravarthy Usha , Teo Kelvin Yi Chong 
Published: April 2021

AbstractBackgroundTo assess the association between variation in retinal central subfield thickness (CSFT) with best‐corrected visual acuity (BCVA) change in patients receiving vascular endothelial growth factor (VEGF) inhibitor therapy for neovascular age‐related macular degeneration (nAMD).MethodsCSFT measurements were obtained from 141 eyes (total 1300 scans). SD of CSFT was calculated. The eyes were categorised into CSFT variation tertiles. Multiple linear regression was used to examine the association between the CSFT tertiles and BCVA change at 12 mo, adjusting for differences in baseline demographic and clinical characteristics.ResultsAt 12 mo, the mean BCVA of the high CSFT variation group (50.6 letters) was significantly lower than the low and moderate CSFT variation groups (57.5 and 59.8 letters, respectively), P = .02. The adjusted mean BCVA gains were +1.7, +7.2, and +7.8 letters in the high, moderate and low CSFT variation groups, respectively (P = .03).ConclusionsA greater variation in retinal thickness during VEGF inhibitor therapy for nAMD is associated with a less favourable visual outcome. CSFT stability is useful in prognosticating visual outcomes in VEGF inhibitor therapy for nAMD.
Narratives on leaving care in Switzerland: Biographies and discourses in the 20th century
Authors: Keller Samuel , Gabriel Thomas , Bombach Clara 
Published: April 2021

AbstractResearch on institutional care and its long‐term effect on life trajectories provides crucial and sometimes unexpected insights. In a qualitative study in Switzerland, we have conducted 37 narrative interviews with people who experienced residential care between 1950 and 1990. The analysis was based on a reconstructive life course perspective and grounded theory. The findings show a complex interplay of residential care context (here: narratives from expert discourses) and intersubjective experiences during and after care. Most interviewees learned from their experiences to be sceptical of social relationships and of all kinds of state interventions—even decades after having left. A few were able to take charge of their lives and steer them in an individually successful direction. In these cases too, results point to fragile concepts of success. Thus, critical questions about residential care in these decades remain. We suggest that rather than abolish residential care facilities, we need to gather more evidence about the factors that contribute to high‐quality out‐of‐home‐placements. As professional settings, they can enable young people individually. They need to avoid responding to children as ‘objects of care’, by neglecting all subjective dimensions and reproducing a pattern of powerlessness with a strong focus on formal, measurable goals.
The impact of COVID‐19 on food retail and food service in Canada: A second assessment
Authors: Goddard Ellen 
Published: April 2021

AbstractCOVID‐19 continues to impose a series of unique challenges on the food retail and food service sectors in Canada. In May 2020, the expectation was that the public health crisis shutdowns of the restaurant sector would be temporary. Although we may still be in a much longer temporary than was originally envisaged, it is becoming clearer that permanent restructuring may also have happened. Grocery stores have solidified their changed realities through an increased focus on multiple channel retailing rather than a complete choice between either bricks and mortar or online. Increased costs, resulting from the pandemic, are continuing to filter through the food system and we have a growing problem with food security for some Canadians given that employment in January 2021 was found to be at its lowest level since August 2020. Unemployment moves directly with lockdowns that are varied across the country.
Simultaneous diversification of Polypodiales and angiosperms in the Mesozoic
Authors: Du Xin‐Yu , Lu Jin‐Mei , Zhang Li‐Bing , Wen Jun , Kuo Li‐Yaung , Mynssen Claudine M. , Schneider Harald , Li De‐Zhu 
Published: April 2021

AbstractComprising about 82% of the extant fern species diversity, Polypodiales are generally believed to have diversified in the Late Cretaceous. We estimated the divergence times of Polypodiales using both penalized likelihood and Bayesian methods, based on a dataset consisting of 208 plastomes representing all 28 families and 14 fossil constraints reflecting current interpretations of fossil record. Our plastome phylogeny recovered the same six major lineages as a recent nuclear phylogeny, but the position of Dennstaedtiineae was different. The present phylogeny showed high resolution of relationships among the families of Polypodiales, especially among those forming the Aspleniineae. The divergence time estimates supported the most recent common ancestor of Polypodiales and its closest relative dating back to the Triassic, establishment of the major lineages in the Jurassic, and a likely accelerated radiation during the late Jurassic and the Early Cretaceous. The estimated divergence patterns of Polypodiales and angiosperms converge to a scenario in which their main lineages were established simultaneously shortly before the onset of the Cretaceous Terrestrial Revolution, and further suggest a pre‐Cretaceous hidden history for both lineages. The pattern of simultaneous diversifications shown here elucidate an important gap in our understanding of the Terrestrial Revolution that shaped today’s ecosystems.
Board Age Diversity and the Future of Museum Leadership
Authors: Carr Christina 
Published: April 2021

AbstractAge diversity is an often‐overlooked dimension of museum board diversity, yet the future of board leadership lies with younger generations, and museum sustainability in the present also depends on the contributions of younger patrons today. Critical issues of board representation cannot be fixed overnight, but a step in the right direction is board age diversity. As the entity that hires and evaluates the executive director and provides fiscal oversight for the institution, it is crucial that the board reflects the demographics and values of the people the museum is trying to serve. Younger generations are more socially connected and socially aware, and they want to change the world now; data, however, suggests that fewer young people see museums as aligning with these values, creating an urgency to engage and build loyalty with these next generation patrons. Recruiting board members without decades of professional experience makes it imperative that museums prioritize leadership development from the beginning. By cultivating younger donors for future giving and leadership positions and capitalizing on their unique insights now, museums will be able to remain relevant for years to come. This article presents a detailed action plan for museums on how to recruit, develop, and retain younger board members to ensure museum sustainability now and in the future.
Postoperativer Verlauf von 150 Patienten nach Wächterlymphknotenbiopsie in Tumeszenz‐Lokalanästhesie
Authors: Eckardt Julia , Häfner Hans‐Martin , Kofler Katrin , Mroz Gabi , Scheu Alexander , Schulz Claudia , Kofler Lukas 
Published: April 2021

ZusammenfassungHintergrundFür die Stadieneinteilung von Patienten mit malignem Melanom ist die Wächterlymphknotenbiopsie (WLKB) eine wichtige Methode. Meist erfolgt die WLKB in Vollnarkose (VN). Sie kann auch in Tumeszenz‐Lokalanästhesie (TLA) durchgeführt werden, jedoch liegen wenige Daten zur WLKB in TLA vor. In dieser Studie wurden die Daten von 150 Patienten mit WLKB in TLA ausgewertet.Patienten und MethodikDie Daten von 150 Patienten mit malignem Melanom der Haut wurden prospektiv analysiert. Schmerzen, Komplikationen und die Patientenzufriedenheit nach WLKB in TLA wurden ausgewertet.Ergebnisse32 % der Patienten berichteten über postoperative Schmerzen innerhalb der ersten 48 Stunden nach WLKB. Das Serom war die häufigste Komplikation. Es traten 29 Serome nach WLKB auf. Eine Wundinfektion wurde bei 3,3 % der Patienten beobachtet. 98,7 % der Patienten waren mit der WLKB in TLA zufrieden.SchlussfolgerungenWLKB in TLA ist eine sichere und praktikable Option und sollte bei Patienten mit Melanom in Betracht gezogen werden. Insbesondere bei multimorbiden oder älteren Patienten können die Risiken der VN vermieden werden.
On grief's sweet sorrow
Authors: Atkins Ashley 
Published: April 2021

AbstractThis paper draws attention to a neglected aspect of grief: its “sweet” sorrow. This sorrow presents us with a formidable challenge, namely, to explain how what is bitter—the misery of loss—can be found to be sweet. Those drawn into this sorrow suspect that it is somehow too sweet. Are their suspicions well founded? Why is it and it alone sweet to those who delight in it and why is it not just sweet but companion‐like and even dear? Guided by the observations of St. Augustine and C. S. Lewis, I propose that this sorrow is a form of self‐pity that displaces the significant other from the center of one's concern and affords an enhanced intimacy with oneself. The proposal vindicates the impression that one finds in this sorrow a companion that can take the place of the significant other and also positions us to address one of the most fundamental questions that might be raised in connection with grief, namely, whether the one who has died is a proper object of concern or whether our grief is ultimately for ourselves, for a loss that is ours and ours alone.
Scientific procedures and rationales for systematic literature reviews (SPAR‐4‐SLR)
Authors: Paul Justin , Lim Weng Marc , O’Cass Aron , Hao Andy Wei , Bresciani Stefano 
Published: April 2021

AbstractMany guiding articles on literature reviews exist, but few have delivered an authoritative protocol that researchers can rely upon with clarity and confidence. To commemorate the inaugural annual special issue on systematic literature reviews in the International Journal of Consumer Studies, the editors have pooled their expertize and experience of authoring, editing, and reviewing literature reviews to develop a rigorous review protocol—that is, the Scientific Procedures and Rationales for Systematic Literature Reviews (SPAR‐4‐SLR) protocol—that researchers can rely upon to guide and justify decisions in systematic literature reviews. Using an interrogative approach, the editors begin with a discussion of the “what,” “why,” “when,” “where,” “who,” and “how” of systematic literature reviews. The editors conclude with systematic literature review exemplars in the inaugural special issue.
Evaluation of a commercial set of frozen plasmas for instrument‐to‐instrument comparability
Authors: De Sloovere Maxime M.W. , Devreese Katrien M.J. 
Published: April 2021

AbstractIntroductionTo perform comparability of instruments, the laboratory can select patient samples spanning the reportable range or can use plasma sets from commercial suppliers. We evaluated ExpertCor Routine (ECR) plasma set (Stago), a set of frozen plasmas enabling to verify the agreement between different coagulation analysers. Additionally, we evaluated whether the concept of transference of the reference range is acceptable between instruments, once comparability between the instruments is approved.MethodsPatient samples and the ECR plasma set were evaluated for method comparison for prothrombin time, activated partial thromboplastin time and fibrinogen on five instruments. Results of one instrument were compared to the mean of all analysers by Passing‐Bablok regression and Bland‐Altman analysis. Reference ranges were checked on all instruments.ResultsThe %mean difference was ≤5% and ≤3.7% for all analyser/parameter combinations, for ECR and patient sample data sets, respectively. All predefined criteria to fulfil good comparability between instruments were met. The between‐instrument comparison with the ECR plasma set and the patient samples was equal for PT, INR and fibrinogen. After demonstrating comparability between instruments by either of the two plasma sample sets, reference ranges can be used interchangeably between identical instruments.ConclusionInstrument‐to‐instrument reproducibility showed comparable results using a data set obtained with patient samples or a commercial plasma set. Once comparability between instruments is confirmed, defined reference ranges can be transferred from one instrument to the other instrument without additional testing. The ECR plasma set is a good alternative to the use of local patient samples to evaluate instrument comparability.
Massive open online courses for nurses’ and healthcare professionals’ continuous education: a scoping review
Authors: Longhini Jessica , Rossettini Giacomo , Palese Alvisa 
Published: April 2021

AimTo map the main characteristics of massive open online courses, and their effectiveness, facilitators and barriers in continuing education among nurses and other healthcare professionals.BackgroundOnline continuous education attracted new attention among educators and managers with regard to how to best design, implement it and evaluate its effectiveness.IntroductionNo studies to date have mapped the state of research on massive open online courses and the facilitators promoting their effectiveness in continuing education.MethodsA scoping review performed in 2020 by following the Preferred Reporting Items for Systematic reviews and Meta‐analysis extension‐Scoping Reviews. Electronic databases were searched for primary and secondary studies, written in English. Identified barriers/facilitators were categorized using a content analysis.ResultsOf the 1149 studies, 31 were included, and the majority had an explorative research design. Massive open online courses documented to date are characterized by their (a) developers’ countries and providers, mainly the United Stated and universities, respectively; (b) variety of teaching methods and contents, including infectious diseases; (c) using both qualitative and quantitative assessment methods; and (d) multidisciplinary target audience ranging from 40 to 83 000 participants, including nurses. Facilitators of and barriers to effectiveness depend on their pedagogical background, appropriate course design, delivery and implementation as well as on the learners’ profile.DiscussionStudies available to date are mainly based on experiential projects. A variety of strategies promoting massive online courses’ effectiveness have emerged.ConclusionSome public health issues may benefit from massive education, as a unique system promoting a quick and effective continuous education.Implications for Nursing/Health/Social PolicyClinical nurses, nurse managers and educators should consider available evidence on massive online courses’ when making decisions on which strategy to use to maintain competencies. Moreover, as a public health tool, massive online courses should be derived from a strong cooperation between political, scientific and professional bodies.
Evaluation of the Accuracy of Nursing Diagnoses Determined by Users of a Clinical Decision Support System
Authors: Diogo Regina Célia dos Santos , Gengo Rita de Cassio , Butcher Silva , Peres Heloísa Helena Ciqueto 
Published: April 2021

AbstractPurposeTo analyze the accuracy of nursing diagnoses determined by users of a clinical decision support system (CDSS) and to identify the predictive factors of high/moderate diagnostic accuracy.MethodsThis is an exploratory‐descriptive study carried out from September 2017 to January 2018. Participants were nurses, resident nurses, and senior year undergraduates. Two written case studies provided the participants with the clinical data to fill out the assessment forms in the CDSS. The accuracy of the selected diagnostic labels was determined by a panel of experts using the Diagnostic Accuracy Scale, Version 2. Descriptive statistics were used to describe the level of accuracy according to each group of participants. Analysis of variance was used to compare the mean percentages of accuracy categories across groups. A linear regression model was used to identify the predictors of diagnostic accuracy. The significance level was 5%. The study was approved by the Ethics Committee.ResultsFifteen undergraduates, 10 residents, and 22 nurses were enrolled in the study. Although resident nurses and students had selected predominantly highly accurate diagnoses (51.8 ± 19.1 and 48.9 ± 27.4, respectively), and nurses had selected mostly diagnoses of moderate accuracy (54.7 ± 14.7), there were no differences in the accuracy level of selected diagnoses across groups. According to the linear regression model, each diagnosis added by the participants decreased the diagnostic accuracy by 2.09% (p = .030), and no experience or a low level of experience using the system decreased such diagnostic accuracy by 5.41% (p = .022).ConclusionsThe CDSS contributes to decision making about diagnoses of less experienced people. Adding diagnoses not indicated by the CDSS and experience with the system are predictors of diagnostic accuracy.Clinical RelevanceIn‐service education regarding the use of CDSSs seems to be crucial to improve users’ clinical judgment and decision making.
Diagnostic and therapeutic implications of vitamin D deficiency in patients with warts: A case‐controlled study
Authors: Shalaby Mamoun E. , Hasan Mohamed S. , Elshorbagy Mohammed S. , Abo Raya Ahmed R. , Elsaie Mohamed L. 
Published: April 2021

AbstractBackgroundCutaneous warts are frequent conditions that possess much challenge to treat.ObjectiveTo verify the potential role of vitamin D in the pathogenesis of viral warts by measuring the serum levels of vitamin D in patients diagnosed with viral warts compared to healthy controls and to verify whether oral vitamin D supplementation of those vitamin D‐deficient patients would result in wart clearance.MethodsTo evaluate the serum vitamin D levels, the study recruited 80 subjects, including 40 patients diagnosed with viral warts and 40 age‐ and sex‐matched healthy controls. All patients were subjected to detailed history taking and examination to detect duration and type of warts. Serum vitamin D levels were measured using ELISA.ResultsThirty‐five percent of patients had sufficient vitamin D levels (54–90 nmol/L), and 40% of patients had insufficient levels (50–80 nmol/L), while 25% of them had deficient levels (<50 nmol/L). In healthy group, 30% had sufficient levels, and 45% had insufficient levels, while 25% had deficient levels. There was an insignificantly lower serum level of vitamin D as well as an insignificantly deficient vitamin D status among patients compared to healthy controls.ConclusionVitamin D serum levels appear to be lower among viral wart patients, and oral supplementation studies need to be more intensely investigated before elucidating its role; if any, in wart clearance.