bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking sediment supply variations and tectonic evolution in deep time, source-to-sink systems—The Triassic Greater Barents Sea Basin
Authors: Gilmullina Albina , Klausen Tore Grane , Doré Anthony George , Rossi Valentina Marzia , Suslova Anna , Eide Christian Haug 
Published: November 2021

Abstract
Triassic strata in the Greater Barents Sea Basin are important records of geodynamic activity in the surrounding catchments and sediment transport in the Arctic basins. This study is the first attempt to investigate the evolution of these source areas through time. Our analysis of sediment budgets from subsurface data in the Greater Barents Sea Basin and application of the BQART approach to estimate catchment properties shows that (1) during the Lower Triassic, sediment supply was at its peak in the basin and comparable to that of the biggest modern-day river systems, which are supplied by tectonically active orogens; (2) the Middle Triassic sediment load was significantly lower but still comparable to that of the top 10 largest modern rivers; (3) during the Upper Triassic, sediment load increased again in the Carnian; and (4) there is a large mismatch (70%) between the modeled and estimated sediment load of the Carnian. These results are consistent with the Triassic Greater Barents Sea Basin succession being deposited under the influence of the largest volcanic event ever at the Permian-Triassic boundary (Siberian Traps) and concurrent with the climatic changes of the Carnian Pluvial Event and the final stages of the Northern Ural orogeny. They also provide a better understanding of geodynamic impacts on sedimentary systems and improve our knowledge of continental-scale sediment transport. Finally, the study demonstrates bypass of sediment from the Ural Mountains and West Siberia into the adjacent Arctic Sverdrup, Chukotka, and Alaska Basins in Late Carnian and Late Norian time.
Healthy People Countdown 2030: reaching 5% cigarette smoking prevalence among US adults through state cigarette excise tax increases
Authors: Nargis Nigar 
Published: November 2021

ObjectiveThe Healthy People 2030 goal is to reduce US current adult cigarette smoking prevalence to 5% by 2030. The objective of this report is to investigate if this goal is achievable using state cigarette excise tax increases.MethodsState-specific linear trends in smoking prevalence over 2011–2019 were determined using fractional logit regression and compared with the desired linear trends for achieving 5% smoking prevalence by 2030 in individual states and the District of Columbia (DC). The gaps between price-adjusted and desired trends were used in a simulation model for identifying state-specific systematic annual increases in state cigarette excise tax rates based on state-specific price elasticity of smoking prevalence, maintaining the status quo in other non-tax tobacco control measures.ResultsThe price-adjusted trends in smoking prevalence observed over 2011–2019 exceed the desired trends for achieving 5% smoking prevalence target by 2030 in only five states (eg, Washington, Utah, Rhode Island, Massachusetts and Maryland) and the DC. It suggests that majority of states and USA overall will miss the target smoking prevalence at the current rate of reduction in smoking. 45 states would need systematic annual increases in cigarette excise tax rate in a range of $0.02–$1.37 per pack over 2022–2030 to meet the target.ConclusionsThe feasibility of reaching the Healthy People 2030 goal would critically depend on the acceleration of progress in tobacco control. Tax increases tailored to the needs of individual states combined with scaled-up non-tax tobacco control policy interventions can help achieve the desired progress.
On perturbative aspects of a nonminimal Lorentz-violating QED with CPT-odd dimension-5 terms
Authors: Mariz T. , Martinez R. , Nascimento J. R. , Petrov A. Yu. 
Published: November 2021

AbstractWe consider the Lorentz-violating extended QED involving all nonminimal dimension-5 additive CPT-odd terms. For this theory, we investigate the generation of the Carroll–Field–Jackiw (CFJ) term and its higher-derivative counterparts of the first order in any of these nonminimal couplings. The CFJ term is demonstrated to vanish in the dimensional regularization scheme. We also study the question of higher-derivative divergent contributions and demonstrate that they can be eliminated by considering a given proportionality between the coefficients.
A profile-based sentiment-aware approach for depression detection in social media
Authors: Titla-Tlatelpa José de Jesús , Ortega-Mendoza Rosa María , Montes-y-Gómez Manuel , Villaseñor-Pineda Luis 
Published: November 2021

AbstractDepression is a severe mental health problem. Due to its relevance, the development of computational tools for its detection has attracted increasing attention in recent years. In this context, several research works have addressed the problem using word-based approaches (e.g., a bag of words). This type of representation has shown to be useful, indicating that words act as linguistic markers of depression. However, we believe that in addition to words, their contexts contain implicitly valuable information that could be inferred and exploited to enhance the detection of signs of depression. Specifically, we explore the use of user’s characteristics and the expressed sentiments in the messages as context insights. The main idea is that the words’ discriminative value depends on the characteristics of the person who is writing and on the polarity of the messages where they occur. Hence, this paper introduces a new approach based on specializing the framework of classification to profiles of users (e.g., males or women) and considering the sentiments expressed in the messages through a new text representation that captures their polarity (e.g., positive or negative). The proposed approach was evaluated on benchmark datasets from social media; the results achieved are encouraging, since they outperform those of state-of-the-art corresponding to computationally more expensive methods.
Phenotypic Changes of LncRNA Hotair in Non-Small-Cell Lung Cancer and Its Clinical Application
Authors: Huang Haihua , Wang Jin , Liu Fabing 
Published: November 2021

Non-small-cell lung cancer (NSCLC) is one of the main causes of death of malignant tumors of the respiratory system. At present, the clinical demand for biomarkers for predicting and diagnosing the disease is increasing. Overexpression of LncRNA Hotair (Homeobox transcriptional antisense intergenic RNA) has been previously reported to be associated with poor prognosis and high mortality in different malignancies. qRT-PCR results showed that the expression of LncRNA Hotair in tumor tissue and serum of patients with non-small-cell lung cancer was significantly upregulated. Clinicopathological correlation analysis showed that the upregulation of LncRNA Hotair expression was closely related to lymph node metastasis and tumor lymph node metastasis (TNM) stage (

P

< 0.05). The results showed that transfection of pcDNA3.1-Hotair could promote the expression of LncRNA Hotair in NSCLC, while transfection of Si-Hotair could reduce the expression level of LncRNA Hotair, hinder the migration and invasion of cancer cells, and promote cell apoptosis. After transfection of Si-Hotair, molecular markers related to migration, the level of E-cadherin and Bax, increased and the level of vimentin, Bcl-2, MMP-3, VEGF, Ki-67 and PCNA decreased. This shows that the proliferation and migration of A549 cells are promoted and LncRNA Hotair deletion can inhibit the proliferation and migration of lung cancer cells. These results show that the expression level of LncRNA Hotair of NSCLC cell lines can promote the invasion and migration of NSCLC, and its expression has a significant correlation with Lymph node metastasis, tumor size, and TNM stage. Therefore, this target is of great significance for the clinical diagnosis and treatment of NSCLC.
Development, Optimization, and Evaluation of Luliconazole Nanoemulgel for the Treatment of Fungal Infection
Authors: Alhakamy Nabil A. , Md Shadab , Alam Md Shoaib , Shaik Rasheed A. , Ahmad Javed , Ahmad Abrar , Kutbi Hussam I. , Noor Ahmad O. , Bagalagel Alaa , Bannan Douha F. , Gorain Bapi , Sivakumar Ponnurengam Malliappan 
Published: November 2021

The present study aimed to optimize luliconazole nanoemulsion using Box–Behnken statistical design, which was further incorporated into the polymeric gel of Carbopol 934. The formulation was characterized for its size, entrapment efficiency, ex vivo permeation, and mechanism of release. The size of the dispersed globules of the optimized drug-loaded nanoemulsion was found to be 17 ± 3.67 nm with a polydispersity index (PDI) less than 0.5. Although the surface charge was recorded at –9.53 ± 0.251, the stability was maintained by the polymeric matrix that prevented aggregation and coalescence of the dispersed globules. The luliconazole-nanoemulgel (LUL-NEG) was characterized for drug content analysis, viscosity, pH, and refractive index, where the results were found to be 99.06 ± 0.59%, 9.26 ± 0.08 Pa.s, 5.65 ± 0.17, and 1.31 ± 0.08, respectively. The permeation across the rat skin was found to be significantly higher with LUL-NEG when compared with LUL gel. Furthermore, the skin irritation test performed in experimental animals revealed that the blank NEG, as well as the LUL-NEG, did not produce any signs of erythema following 48 h exposure. In addition, the histopathological findings of the experimental skins reported no abnormal signs at the formulation application site. Finally, the NEG formulation was found to create a statistically significant zone of inhibition (

P

< 0.05) when compared to all other test groups. Overall, it could be summarized that the nanoemulgel approach of delivering luliconazole across the skin to treat skin fungal infections could be a promising strategy.
Association between Markers of Fibrosis and Heart Failure Incidence in Patients with Type 2 Diabetes Mellitus
Authors: Lebedev Denis A. , Lyasnikova Elena A. , Vasilyeva Elena Yu. , Likhonosov Nikolai P. , Sitnikova Maria Yu. , Babenko Alina Yu. 
Published: November 2021

Type 2 diabetes mellitus (T2DM) and chronic heart failure (HF) have close association, and several biomarkers have been studied to better understand this association and improve prediction of HF in T2DM. Furthermore, in recent clinical trials, sodium glucose cotransporter 2 inhibitors (SGLT2i), glucose-lowering drugs, improved HF outcomes. The objective of the present study was to evaluate association between circulating biomarkers of fibrosis and incidence of HF with preserved ejection fraction (HFpEF) in patients with T2DM receiving sodium glucose cotransporter 2 inhibitors (SGLT2i). Materials and Methods. At baseline, transthoracic echocardiography and laboratory assessment of N-terminal fragment of the brain natriuretic peptide (Nt-proBNP), soluble suppression of tumorigenesis-2 (sST2), galectin-3 (Gal-3), C-terminal propeptide of procollagen type I (PICP), N-terminal propeptide of procollagen type III (PIIINP), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of matrix proteinase-1 (TIMP-1) were done. After 3 years of follow-up, information about HF events (hospitalization for HF, established HF in outpatient department by a cardiologist) was obtained. Results. Seventy-two patients were included in the study. The mean age was 57 (49.7; 63.2) years; 44% were female. Most patients had T2DM for more than 4 years. All patients were overweight or had obesity, and 93% patients had arterial hypertension (AH). After 3 years of follow-up, HFpEF was established in 21% patients. Patients were divided into two groups according to the presence of HFpEF, and baseline characteristics were compared. Patients with HF were older and had longer diabetes and AH duration and higher Nt-proBNP, Gal-3, PIIINP, and PICP levels at baseline than patients without HF (all

p
<
0.05

).

Gal
−
3
>
10

ng/ml (

OR
=
2.25

; 95% CI, 1.88–5.66;

p
=
0.01

) and

NT
−
pro
−
BNP
>
80

pg/ml (

OR
=
2.64

; 95% CI, 1.56–4.44;

p
=
0.001

) were associated with increased risk of HF incidence.

Age
>
60

years, diabetes

duration
>
10

years, and presence of abdominal obesity were independent predictors of HFpEF as well. Conclusions. T2DM patients treated with SLGT2i, who developed HFpEF after 3 years of follow-up, had higher PICP, PIIINP, Gal-3, and NT-proBNP serum concentrations at baseline, and Gal-3 level was an independent predictor of HFpEF.
Amulet or Watchman Device for Percutaneous Left Atrial Appendage Closure: Primary Results of the SWISS-APERO Randomized Clinical Trial
Authors: Galea Roberto , De Marco Federico , Meneveau Nicolas , Aminian Adel , Anselme Frédéric , Gräni Christoph , Huber Adrian T. , Teiger Emmanuel , Iriart Xavier , Babongo Bosombo Flora , Heg Dik , Franzone Anna , Vranckx Pascal , Fischer Urs , Pedrazzini Giovanni , Bedogni Francesco , Räber Lorenz , Valgimigli Marco 
Published: November 2021

Background:
No study has so far compared Amulet with the new Watchman FLX in terms of residual left atrial appendage (LAA) patency or clinical outcomes in patients undergoing percutaneous LAA closure.

Methods:
In the investigator-initiated SWISS APERO trial (Comparison of Amulet Versus Watchman/FLX Device in Patients Undergoing Left Atrial Appendage Closure), patients undergoing LAA closure were randomly assigned (1:1) open label to receive Amulet or Watchman 2.5 or FLX (Watchman) across 8 European centers. The primary end point was the composite of justified crossover to a nonrandomized device during LAA closure procedure or residual LAA patency detected by cardiac computed tomography angiography (CCTA) at 45 days. The secondary end points included procedural complications, device-related thrombus, peridevice leak at transesophageal echocardiography, and clinical outcomes at 45 days.

Results:

Between June 2018 and May 2021, 221 patients were randomly assigned to Amulet (111 [50.2%]) or Watchman (110 [49.8%]), of whom 25 (22.7%) patients included before October 2019 received Watchman 2.5, and 85 (77.3%) patients received Watchman FLX. The primary end point was assessable in 205 (92.8%) patients and occurred in 71 (67.6%) patients receiving Amulet and 70 (70.0%) patients receiving Watchman, respectively (risk ratio, 0.97 [95% CI, 0.80–1.16];
P
=0.713). A single justified crossover occurred in a patient with Amulet who fulfilled LAA patency criteria at 45-day CCTA. Major procedure-related complications occurred more frequently in the Amulet group (9.0% versus 2.7%;
P
=0.047) because of more frequent bleeding (7.2% versus 1.8%). At 45 days, the peridevice leak rate at transesophageal echocardiography was higher with Watchman than with Amulet (27.5% versus 13.7%,
P
=0.020), albeit none was major (ie, >5 mm), whereas device-related thrombus was detected in 1 (0.9%) patient with Amulet and 3 (3.0%) patients with Watchman at CCTA and in 2 (2.1%) and 5 (5.5%) patients at transesophageal echocardiography, respectively. Clinical outcomes at 45 days did not differ between the groups.

Conclusions:
Amulet was not associated with a lower rate of the composite of crossover or residual LAA patency compared with Watchman at 45-day CCTA. Amulet, however, was associated with lower peridevice leak rates at transesophageal echocardiography, higher procedural complications, and similar clinical outcomes at 45 days compared with Watchman. The clinical relevance of CCTA-detected LAA patency requires further investigation.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03399851.
Development and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm
Authors: Mori Makoto , Gan Geliang , Deng Yanhong , Yousef Sameh , Weininger Gabe , Daggula Krishna R. , Agarwal Ritu , Shang Michael , Assi Roland , Geirsson Arnar , Vallabhajosyula Prashanth 
Published: November 2021

Background
Screening protocols do not exist for ascending thoracic aortic aneurysms (ATAAs). A risk prediction algorithm may aid targeted screening of patients with an undiagnosed ATAA to prevent aortic dissection. We aimed to develop and validate a risk model to identify those at increased risk of having an ATAA, based on readily available clinical information.

Methods and Results
This is a cross‐sectional study of computed tomography scans involving the chest at a tertiary care center on unique patients aged 50 to 85 years between 2013 and 2016. These criteria yielded 21 325 computed tomography scans. The double‐oblique technique was used to measure the ascending thoracic aorta, and an ATAA was defined as >40 mm in diameter. A logistic regression model was fitted for the risk of ATAA, with readily available demographics and comorbidity variables. Model performance was characterized by discrimination and calibration metrics via split‐sample testing. Among the 21 325 patients, there were 560 (2.6%) patients with an ATAA. The multivariable model demonstrated that older age, higher body surface area, history of arrhythmia, aortic valve disease, hypertension, and family history of aortic aneurysm were associated with increased risk of an ATAA, whereas female sex and diabetes were associated with a lower risk of an ATAA. The C statistic of the model was 0.723±0.016. The regression coefficients were transformed to scores that allow for point‐of‐care calculation of patients' risk.

Conclusions
We developed and internally validated a model to predict patients' risk of having an ATAA based on demographic and clinical characteristics. This algorithm may guide the targeted screening of an undiagnosed ATAA.
Graded Coronary Risk Stratification for Emergency Department Patients With Chest Pain: A Controlled Cohort Study
Authors: Mark Dustin G. , Huang Jie , Ballard Dustin W. , Kene Mamata V. , Sax Dana R. , Chettipally Uli K. , Lin James S. , Bouvet Sean C. , Cotton Dale M. , Anderson Megan L. , McLachlan Ian D. , Simon Laura E. , Shan Judy , Rauchwerger Adina S. , Vinson David R. , Reed Mary E. , Mark Dustin G , Huang Jie , Ballard Dustin W , Kene Mamata V , Sax Dana R , Chettipally Uli K , Lin James S , Bouvet Sean C , Cotton Dale M , McLachlan Ian D , Vinson David R , Rauchwerger Adina S , Reed Mary E 
Published: November 2021

Background
Resource utilization among emergency department (ED) patients with possible coronary chest pain is highly variable.

Methods and Results

Controlled cohort study amongst 21 EDs of an integrated healthcare system examining the implementation of a graded coronary risk stratification algorithm (RISTRA‐ACS [risk stratification for acute coronary syndrome]). Thirteen EDs had access to RISTRA‐ACS within the electronic health record (RISTRA sites) beginning in month 24 of a 48‐month study period (January 2016 to December 2019); the remaining 8 EDs served as contemporaneous controls. Study participants had a chief complaint of chest pain and serum troponin measurement in the ED. The primary outcome was index visit resource utilization (observation unit or hospital admission, or 7‐day objective cardiac testing). Secondary outcomes were 30‐day objective cardiac testing, 60‐day major adverse cardiac events (MACE), and 60‐day MACE‐CR (MACE excluding coronary revascularization). Difference‐in‐differences analyses controlled for secular trends with stratification by estimated risk and adjustment for risk factors, ED physician and facility. A total of 154 914 encounters were included. Relative to control sites, 30‐day objective cardiac testing decreased at RISTRA sites among patients with low (≤2%) estimated 60‐day MACE risk (−2.5%, 95% CI −3.7 to −1.2%,
P
<0.001) and increased among patients with non‐low (>2%) estimated risk (+2.8%, 95% CI +0.6 to +4.9%,
P
=0.014), without significant overall change (−1.0%, 95% CI −2.1 to 0.1%,
P
=0.079). There were no statistically significant differences in index visit resource utilization, 60‐day MACE or 60‐day MACE‐CR.

Conclusions
Implementation of RISTRA‐ACS was associated with better allocation of 30‐day objective cardiac testing and no change in index visit resource utilization or 60‐day MACE.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03286179.
Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction
Authors: Kerola Anne M. , Palomäki Antti , Rautava Päivi , Nuotio Maria , Kytö Ville 
Published: November 2021

Background
Evidence on the impact of sex on prognoses after myocardial infarction (MI) among older adults is limited. We evaluated sex differences in long‐term cardiovascular outcomes after MI in older adults.

Methods and Results

All patients with MI ≥70 years admitted to 20 Finnish hospitals during a 10‐year period and discharged alive were studied retrospectively using a combination of national registries (n=31 578, 51% men, mean age 79). The primary outcome was combined major adverse cardiovascular event within 10‐year follow‐up. Sex differences in baseline features were equalized using inverse probability weighting adjustment. Women were older, with different comorbidity profiles and rarer ST‐segment–elevation MI and revascularization, compared with men. Adenosine diphosphate inhibitors, anticoagulation, statins, and high‐dose statins were more frequently used by men, and renin‐angiotensin‐aldosterone inhibitors and beta blockers by women. After balancing these differences by inverse probability weighting, the cumulative 10‐year incidence of major adverse cardiovascular events was 67.7% in men, 62.0% in women (hazard ratio [HR], 1.17; CI, 1.13–1.21;
P
<0.0001). New MI (37.0% in men, 33.1% in women; HR, 1.16;
P
<0.0001), ischemic stroke (21.1% versus 19.5%; HR, 1.10;
P
=0.004), and cardiovascular death (56.0% versus 51.1%; HR, 1.18;
P
<0.0001) were more frequent in men during long‐term follow‐up after MI. Sex differences in major adverse cardiovascular events were similar in subgroups of revascularized and non‐revascularized patients, and in patients 70 to 79 and ≥80 years.

Conclusions
Older men had higher long‐term risk of major adverse cardiovascular events after MI, compared with older women with similar baseline features and evidence‐based medications. Our results highlight the importance of accounting for confounding factors when studying sex differences in cardiovascular outcomes.
The Lives of Marx: Hägglund and Marx’s Philosophy after Pippin and Postone
Authors: Lazarus Michael 
Published: November 2021

Abstract
To make ‘philosophy worldly’ often requires an act of translation. In This Life, Martin Hägglund argues for the relevance of Marx to our contemporary lives. By way of a lively and sophisticated dialogue between philosophical interlocutors – including Hegel and Marx – Hägglund offers a compelling account of the relation between time, value and freedom. This Life translates current issues in academic philosophy into a popular register that does not reduce the complexity of the issues but shows what is at stake for our own lives. Hägglund provides a synthesis of Robert B. Pippin’s normative reading of Hegel and the value-form critical theory of Moishe Postone’s Marxism. Further, Hägglund’s vision of freedom outflanks the political limitations of Pippin’s Hegel and Postone’s Marx while retaining the power of their analyses. I assess his interpretation of Hegel and critically examine the concept of value operative in This Life, and frame this question in terms of value-form theory.