bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Atellica TnIH cardiac troponin I assay and assessment of biological equivalence
Authors: Pretorius Carel J. , Parsonage William , Cullen Louise W. , Wilgen Urs , De Waal Elzahn , Klingberg Sandra , Dimeski Goce , White Rob , Greenslade Jaimi , Ungerer Jacobus P.J. 
Published: November 2021

Abstract

Objectives
We evaluated the analytical performance characteristics and the biological equivalence of the Atellica TnIH assay.

Methods
Precision, detection capability, linearity, and sex specific 99th percentiles were determined de novo. Classification of patients relative to the 99th percentiles was used to assess biological equivalence.

Results
Analytical precision and detection capability of the Atellica TnIH assay is excellent with a limit of blank <1 ng/L and 62.5% of women and 93% of men had results above the limit of detection. The 99th percentiles (90% CI) in women were 49 ng/L (31–67) and 70 ng/L (48–121) in men. An asymmetrical distribution involving 5% of results was notable. Agreement was moderate (Kappa 0.58, 95% CI 0.53–0.63) with 20% of patients discordantly classified with Atellica TnIH below and Access hsTnI above the 99th percentiles. Serial results in 195 patients demonstrated good agreement (Kappa 0.84, 95% CI 0.77–0.90). Differences greater than the assay specific reference change values (z≥±1.96) occurred in 65% (95% CI 53–76%) of 99th percentile discordant patients compared to 2.7% (p<0.001) and 76% (p=0.17) of the concordant low and high cTnI groups respectively.

Conclusions
The 99th percentile discordant and the concordantly elevated groups are more alike with respect to their z≥±1.96 rates. This favours an overestimated Atellica TnIH 99th percentile as more likely, and we hypothesize that antibody interference resulting in asymmetric scatter of nearly 5% samples may be the underlying mechanism. Analytical accuracy and interferences in cardiac troponin assays should be investigated and resolved with high priority.
Dependence of specific absorption rate and its distribution inside a homogeneous fruit model on frequency, angle of incidence, and wave polarization
Authors: Kundu Ardhendu , Gupta Bhaskar , Mallick Amirul I. 
Published: November 2021

Abstract
Electromagnetic regulatory guidelines prescribed by the international and national organizations are in effect worldwide to protect humans from immediate health effects. For restricting human exposure to electromagnetic radiation in near field, a quantitative term ‘specific absorption rate (SAR) limit’ has been coined and well established in literature. In addition, reference power density limit has also been prescribed in far field for human safety. At the same time, plants and fruits also absorb reasonable amount of electromagnetic energy due to high permittivity and electrical conductivity. Unfortunately, there is not much concern regarding electromagnetic energy absorption in plants and fruits, and no prescribed SAR limit in spite of recent reports in literature. Unlike humans, plants and fruits are of asymmetric shapes and sizes; therefore even at a particular frequency and fixed reference power density, electromagnetic energy absorption rate i.e., SAR in plants and fruits is expected to differ depending upon angle of incidence and wave polarization. To address these issues in detail, a typical bunch of three single layered water apples has been prototyped and exposed to plane wave irradiation at five different frequency bands as per the existing Indian electromagnetic regulatory guidelines. Broadband dielectric properties of water apples have been measured using open ended coaxial probe technique; thereafter, measured dielectric properties have been fed into the designed model. At a particular frequency, reasonable variations in magnitude and position of maximum local point (MLP) SAR, 1 g averaged SAR, and 10 g averaged SAR data have been noted for six different combinations of angle of incidence and wave polarization. This whole course of action is repeated over five different frequency bands. Moreover, variations in observed SAR data are also compared with previously reported variations in SAR data for a multilayer fruit structure. Observations indicate different order of changes in SAR for different fruit structures due to similar combinations of frequency, power density, angle of incidence, and wave polarization. Hence, direct definition of SAR limits for plant and fruit structures should be adopted even in far field in conjunction with reference power density.
Antibacterial greener silver nanoparticles synthesized using Marsilea quadrifolia extract and their eco-friendly evaluation against Zika virus vector, Aedes aegypti
Authors: Ishwarya Ramachandran , Saravanan Kavitha , Selvaraj Daniel , Govindarajan Marimuthu , Alharbi Naiyf S. , Kadaikunnan Shine , Khaled Jamal M. , Sivakamavalli Jeyachandran , Selvakumar Thangaswamy , Vaseeharan Baskaralingam 
Published: November 2021

Abstract
Fabrication and use of nanoparticles have progressively enlarged within the last decade. Herein the silver nanoparticles (AgNps) were synthesized via the extract from Marsilea quadrifolia (Mq) as a decreasing and steadying mediator. The Mq-AgNPs demonstrated superior toxicity on Zika virus vector, Aedes aegypti with the LC50 value of 10.69 µg·mL−1. The Mq-AgNPs were established securely to non-target organisms Artemia nauplii and Ceriodaphnia cornuta, and no structural or anatomical alterations confirm its security to the surroundings. The antibacterial activity exposed that Mq-AgNPs showed superior growth inhibition effect against the tested bacteria. Furthermore, the Mq-AgNPs showed strong antioxidant activities when compared to Mq leaf extract. Overall, our results highlight that Mq-AgNPs are hopeful and biodegradable devices against mosquito vectors of therapeutic significance, with moderate toxicity against non-target aquatic animals.
Curcumin-removed turmeric oleoresin nano-emulsion as a novel botanical fungicide to control anthracnose (Colletotrichum gloeosporioides) in litchi
Authors: Bui Van Cuong , Le The Tam , Nguyen Tuyen Hong , Pham Nam Thi , Vu Hoang Dinh , Nguyen Xuan Canh , De Tran Quang , Hoang Thai , Le Dang Quang , Lam Tran Dai 
Published: November 2021

Abstract
During curcumin production in Vietnam, curcumin-removed turmeric oleoresin (CRTO) has been considered as a by-product. It costs to treat the by-product to prevent environmental pollution. In this study, the by-product was utilized as an active ingredient for preparing a botanical fungicide-based nano-emulsion and evaluated for its in vitro and in vivo control efficacy against Colletotrichum gloeosporioides, a causal agent of anthracnose of litchi, in the laboratory as well as a field trial. The nano-emulsion is colloidally stable and uniform with particle sizes of 95–250 nm. CRTO nano-emulsion significantly affected various Colletotrichum species. Notably, this nano-emulsion showed potent inhibition for the mycelial growth of C. gloeosporioides and solidly suppressed the development of anthracnose on litchi fruits. In the in vitro inhibition test, the equivalent half-maximal inhibitory concentration of CRTO in nano-formulation was 0.11 mg·mL−1, which was 3.0× and 6.1× lower than IC50 values of CRTO alone (0.33 mg·mL−1) and a mixture of curcuminoids (0.48 mg·mL−1), respectively. In the field trial, the litchi anthracnose infection was effectively controlled by nano-formulation. These results suggest that CRTO nano-emulsion could be used as an alternative to harmful synthetic fungicides to control anthracnose on litchi fruits.
Optimization for simultaneous removal of NH3-N and COD from coking wastewater via a three-dimensional electrode system with coal-based electrode materials by RSM method
Authors: Su Ting , Gao Wenwen , Xing Xiangdong , Lan Xinzhe , Song Yonghui 
Published: November 2021

Abstract
The present work demonstrated preparation of coal-based electrode materials (CEM)-derived low-rank coal for simultaneous removal of ammonia nitrogen (NH3-N) and chemical oxygen demand (COD) from coking wastewater by a three-dimensional electrode system (3DES). The influence of important parameters in 3DES such as processing time, applied voltage, electrode plate spacing, mass of commercially activated carbon (CAC), and initial pH were investigated. Based on the central composite design, the response surface method (RSM) was employed in order to optimize the variable parameters in removal process of pollutants. From the analysis of RSM, the optimum conditions for 3DES were 4.5 h of processing time, 5.5 V of applied voltage, 17 mm electrode plate spacing, 4.5 g CAC, and pH of 3 with higher simultaneous removal rate of COD (74.20%) and NH3-N (51.48%). Besides, the content of N element (4.9%) and N containing groups were traced by SEM-EDS and FTIR analysis in order to verify the removal effect. The experiment results showed the capability of CEM for electrode system removal of pollutants from coking wastewater and obtained considerable simultaneous removal rate of NH3-N and COD.
Shuttle breeding in sunflower lines development
Authors: Gontcharov Sergey V. , Korotkova Tatyana S. , Goloschapova Natalya N. , Nesmyslenov Alexander P. 
Published: November 2021

Abstract
Shuttle breeding is a breeding system where generations undergo sequential evaluations at different locations, developed by N. Borlaug. Our study aims to demonstrate an opportunity of application shuttle breeding method in sunflower lines development and also to show its advantages and disadvantages. Experiments were mainly conducted at the Central Station (Krasnodar) of All-Russia Research Institute of Oil Crops (VNIIMK). Krasnodar region is situated in the Southern part of Russia near the Black Sea. Part of our work was made at Seed and Plant Improvement Institute (Karaj, Iran) and Experimental Station near Borozdjan (Busher Province of Iran). Released and experimental sunflower hybrids and lines of VNIIMK breeding were used as a material. The experimental design was randomized blocks with three replications. Each replication had four rows and two central rows were analyzed only to exclude the border effect. It is shown that the application of the shuttle breeding technique to sunflower was highly successful and results in elite line development.
Investigation of nonlinear fractional delay differential equation via singular fractional operator
Authors: Ahmad Dildar , Ali Amjad , Mahariq Ibrahim , Rahman Ghaus ur , Shah Kamal 
Published: November 2021

Abstract
The present research work is basically devoted to construction of a fractional order differential equation with time delay. Initially, integral representation is given to solution of the underline problem. Afterwards, operator form of solution is studied under some auxiliary hypothesis. Since uniqueness of solution is required, therefore we also provide results for exploring the uniqueness of solution for the underlying model. Using Lebesgue dominated convergence theorem and some other results from analysis, this work provides results devoted to existence of at least one solution. Also, for investigating the nature of solution for the proposed model, we study different kind of stability analysis. These stability related results show, how the solution behave with time. At the end of the article, we illustrate the obtained results via some examples.
Bursting the bubble: hereditary spherocytosis masking poor glycemic control
Authors: Gordon Ashley , Pachu Deep , Hadfield Matthew J. 
Published: November 2021

Abstract
Hemoglobin A1c (HbA1c) is a very common measure utilized to diagnose diabetes and to monitor the level of glycemic control during the course of management. Despite the high utility of HbA1c, it has some limitations. Physiological conditions that affect the lifespan of red blood cells (RBCs) can falsely elevate or lower HbA1c results. In this case report, we present a case of a patient who was found to have hereditary spherocytosis (HS) after developing nephrotic range proteinuria. The patient had diabetes that was previously thought to be well controlled, but his HS was masking his poor glycemic control. This case highlights the importance of understanding the limitations of the HbA1c in managing patients with diabetes.
The First Neolithic Occupation of La Cova del Randero (Pedreguer, Alicante, Spain)
Authors: Roca de Togores Muñoz Consuelo , Sirvent Cañada Laura M. , Amorós Silvia Martínez , Pérez Olga Gómez , González Virginia Barciela , García Carlos Ferrer , Iborra Miguel Benito , Soler Díaz Jorge A. 
Published: November 2021

Abstract
The excavations at “Cova del Randero” (Pedreguer, Alicante, Spain) began in 2007 within the programme of archaeological interventions of the Archaeological Museum of Alicante. The cavity, located in one of the valleys that connect the coast with the inland mountains, presents a wide sequence of occupations that begins in the Upper Palaeolithic and continues throughout the different phases of the Neolithic. The results of a multidisciplinary study, carried out in an archaeological context associated with the first Neolithic presence of the cavity, are presented here. This occupation is defined by a unique combustion structure to which a set of artefacts and biofacts are linked. This archaeological context, probably of a specific nature, is related to the first agro-pastoral communities settled in the area. The fireplace is well defined stratigraphically and sedimentologically because of its reddish soil, which corresponds to hunter-gatherer occupation levels of the cavity, and under the greyish sediments that characterise the use of the cave as a fold during the Middle Neolithic. This occupation event was dated both by the associated materials, among which a fragment of cardial ceramic was found, and by radiocarbon dating of a metacarpus of Ovis aries around 5075–4910 cal BC (epicardial Early Neolithic). This data allows us to link the occupation of the cavity at this time with pastoral activity in a medium mountain environment. However, it also allows us to infer the environmental characteristics in which the first farming communities of the mountains of Alicante were developed.
“The journey will be relaxed. You will watch television. Just like a VIP”: Misinformation, secrecy, and the information behaviour of repatriated migrants in Bangladesh
Authors: Shuva Nafiz Zaman 
Published: November 2021

Abstract
This paper explores the information behaviour of repatriated migrants in Bangladesh in the context of their irregular migration. Using an exploratory qualitative research design, semi-structured interviews were conducted with eight repatriated migrants in Bangladesh. This study provides insights into the culturally situated, complicated information behaviour of repatriated migrants in Bangladesh. The findings of this study show that repatriated migrants did not seek any information in the context of their irregular migration. It is evident that factors such as unrealistic perceptions and expectations about life abroad, desperate desire to relocate to another country, and trust in smugglers and their agents played a key role in their information seeking in the context of their irregular migration. The study revealed that some participants were unaware of the risk of taking an irregular journey and deceived by the misinformation shared by their smugglers and their agents. Some interviewees even claimed not to attempt to move to Malaysia if they were aware of the heavy risks associated with the move. The concepts of “migration as gambling” and “Aladdin’s lamp” emerged in this study have some implications for local informational program development aiming to educate vulnerable rural population about the risk of irregular migration and connect them with reliable migrational information sources. The study identified some information grounds such as the Bazaar and Betel fields, which might be useful in offering informational programs at those grounds. The findings related to the information behaviour of repatriated migrants have potential implications for research in various disciplines, including library and information science, migrational studies, geography, and psychology.
Kant’s Metaphilosophy
Authors: Lewin Michael 
Published: November 2021

AbstractWhile the term “metaphilosophy” enjoys increasing popularity in Kant scholarship, it is neither clear what distinguishes a metaphilosophical theory from a philosophical one nor to what extent Kant’s philosophy contains metaphilosophical views. In the first part of the article, I will introduce a demarcation criterion and show how scholars fall prey to the fallacy of extension confusing Kant’s philosophical theories with his theories about philosophy. In the second part, I will analyze eight elements for an “imperfect definition” (KrVA731/B759) of philosophy outlining the scope of Kant’s explicit metaphilosophy against the backdrop of recent metaphilosophical research: (i) scientific concept of philosophy, (ii) philosophy as an activity, (iii) worldly concept, (iv) philosophy as a (proper and improper) science, (v) philosophy as an architectonic idea (archetype and ectypes), (vi) philosophy as a social practice and the appropriate holding-to-be-true (one or many true philosophies?), (vii) reason as the absolute condition and subject of philosophy, and (viii) methodology of philosophy. I will put these elements together for an attempt to give an imperfect definition of philosophy – something that Kant promised but never did – in the conclusion.
Microvariation in Verbal and Nominal Agreement: An Analysis of Two Lombard Alpine Dialects
Authors: Pescarini Diego 
Published: November 2021

AbstractIn Bregagliotto and Mesolcinese, two Lombard Alpine dialects, feminine plural agreement/concord is marked by the formative -n, a reflex of the third person plural verbal ending. In Bregagliotto, plural -ntriggers mesoclisis of the feminine subject clitic in contexts of inversion, whereas in the noun phrase -nbehaves as a second-position element marking plural feminine concord. Mesolcinese exhibits verbal gender agreement as the formative -noccurs on the inflected verb whenever a feminine plural subject or the feminine plural object clitic occurs; in feminine plural DPs, -nis attached to any element except the definite article. I argue that the Bregagliotto system emerged when -nwas reanalysed as an adjunct pluraliser, whereas in Mesolcinese -nhas been turned into a marker of morphophonological concord/agreement.
On the Acquisition of French (Null) Subjects and (In)Definiteness: Simultaneous and Early Sequential bi-, tri- and Multilinguals
Authors: Arnaus Gil Laia , Stahnke Johanna , Müller Natascha 
Published: November 2021

Abstract
The French non-null-subject parameter is set very early, irrespective of the number of languages acquired. By contrast, the acquisition of (in)definiteness marking takes place at age 11;0. For early parametrized grammatical phenomena, Tsimpli (Tsimpli, Ianthi Maria. 2014. Early, late or very late? Timing acquisition and bilingualism. Linguistic Approaches to Bilingualism 4(3). 283–313.) argues that age of onset (AoO) matters. For late acquired phenomena, language experience is crucial. We recruited 23 simultaneous and 34 early sequential L2 (eL2) learners of French (mean age 4;6). Using an elicitation task, we examined the production of French subjects and (in)definite articles. All children behaved similarly with respect to the (early) setting of the null-subject parameter. In contrast, (in)definite marking was sensitive to number of languages and age; AoO or input effects did not affect the results. Simultaneous multilinguals diverge from eL2 children, showing subject spell-out preferences, interpreted in terms of acquisition phases. We will discuss this result against a model of language acquisition in which the child proceeds in acquisition stages.
Experimental Evidence on Island Effects in Spanish Relative Clauses
Authors: Stigliano Laura , Xiang Ming 
Published: November 2021

AbstractResearch on islands has been central to linguistic theory for more than 50 years. Its importance relies on the theoretical consequences islands posit for movement and long distance dependencies. In this paper we aim to explore the contrast between a variety of islands in Spanish relative clauses to reveal whether there is any gradience in the strength of the island effects. In order to tease apart fine-grained contrasts we run an acceptability judgment study based on the factorial definition of island, an experimental paradigm that aims to isolate the various factors that can affect the acceptability of a sentence involving island violations. Overall, we found that the five constructions tested (embedded wh-questions,whether-clauses, adjuncts, complex NPs and relative clauses) show island effects in Spanish and that there are limited differences in the size of these effects, which points to a more categorical view of islands.
circ_0082375 promotes the progression of glioma by regulating Wnt7B
Authors: Meng Xianbing , Tian Hailong , Guo Wenqiang , Wang Zhigang 
Published: November 2021

Abstract
Circular RNAs contribute to the progression of glioma. However, the biological role and underlying mechanism of circ_0082375 in glioma remain unclear. Quantitative real-time PCR and Western blot assay were used to evaluate the expression levels of circ_0082375, microRNA-485-5p, and Wnt family member 7B (Wnt7B). The overall survival of glioma patients was estimated by the Kaplan–Meier curve. Cell proliferation, apoptosis, invasion, and migration were detected by cell counting kit-8, 5-ethynyl-2 -deoxyuridine (EdU) staining, flow cytometry, and transwell assays, respectively. Glucose level and lactate production were determined using glucose and lactate assay kits. In vitro angiogenesis assay was used to evaluate the angiogenesis of glioma cells. The interaction between microRNA (miR)-485-5p and circ_0082375 or Wnt family member 7B (Wnt7B) was verified by dual-luciferase reporter and RNA immunoprecipitation assays. A xenograft model was used to verify the function of circ_0082375 in vivo. circ_0082375 was upregulated in glioma tissues, and it was closely related to the prognosis of glioma patients. circ_0082375 knockdown suppressed cell proliferation, migration, invasion, angiogenesis, glycolysis, and epithelial-mesenchymal transition (EMT), and promoted cell apoptosis in glioma cells. irc_0082375 was a sponge of miR-485-5p, which directly targeted Wnt7B. Knockdown of circ_0082375 inhibited the malignancy, angiogenesis, and glycolysis of glioma cells in vitro by sponging miR-485-5p. Besides, circ_0082375 knockdown hampered the growth of glioma growth by regulating the miR-485-5p/Wnt7B axis in vivo. Altogether, circ_0082375 regulated miR-485-5p/Wnt7B axis to promote the malignancy, angiogenesis, and glycolysis of glioma cells, thereby contributing to the progression of glioma.
PEMANFAATAN SISTEM INFORMASI APLIKASI ONLINE PUBLIC ACCESS CATALOGUE (OPAC) PADA PERPUSTAKAAN IAIN BATUSANGKAR
Authors: Armizawati Armizawati 
Published: November 2021

Abstract : In this qualitative case study, we examined benefit Online Public Acsses Catalogue (OPAC) in IAIN Library. This research focus to student that use Online Public Access Catalogue (OPAC). This research using Miles & Hubberman model (Reduction data, show data and conclusion). Data were collected purposive sampling through observation and interview. The findings, showed that Online Public Acsses Catalogue (OPAC) give benefit,effective and efisien use to find all book fast. Keyword : Benefit OPAC,Student IAIN BatusangkarAbstrak: Dalam studi kasus kualitatif ini, kami menguji manfaat Online Public Acsses Catalog (OPAC) di Perpustakaan IAIN. Fokus penelitian ini kepada siswa yang menggunakan Katalog Akses Publik Online (OPAC). Penelitian ini menggunakan model Miles & Hubberman (Reduksi data, tunjukkan data dan kesimpulan). Data dikumpulkan secara purposive sampling melalui observasi dan wawancara. Temuan, menunjukkan bahwa Online Public Acsses Catalog (OPAC) memberikan manfaat, efektif dan efisien untuk menemukan semua buku dengan cepat.Kata kunci: Manfaat OPAC, Mahasiswa IAIN Batusangkar