bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production Facility Layout Design Using Activity Relationship Chart (ARC) And From To Chart (FTC) Methods
Authors: Barbara Ata , Cahyana Atikha Sidhi 
Published: August 2021

XYZ is a company engaged in the field of transformers which produces several types of transformers. Transformer production process is made to order a production process that has a fluctuating pattern. Companies also often cannot estimate the number of transformers that will be produced to meet consumer demand.

The purpose of this study is to improve plant layout with an efficient layout. One method used in this study is the Activity Relationship Chart and From To Chart methods. Activity Relationship Chart and From To Chart are methods that can help solve problems which are then explained in more detail through several stages of completion to the optimal point. This research is expected to produce a more efficient layout using the Activity Relationship Chart and From To Chart method.
Personnel Information System Using Microsoft Excel (Case Study: Bima City Health Office)
Authors: Wulan Ramdhani  , Arizona Firdonsyah  
Published: August 2021

Information system is a system that has the ability to collect information from all sources and use various media to display information. Microsoft Excel is a spreasheet application program (electronic worksheet), the function of Microsoft Excel is to perform calculation operations and can present data in table form, while the filter and sort data functions are used to sort or filter data, for example: the ascending function and descending to sort data from the largest or from the smallest, the Sort By and Sort On features, in addition to the filter function to display data with certain criteria, the filter feature function or often referred to as autofilter, which functions to display certain rows of data according to filters already applied and hides the rest of the remaining rows of data. This study aims to facilitate the search for staffing data at the Health Office of the City of Bima, the method of data collection using 2 methods, namely literature study and observation, the results of research that have been conducted are that there is no personnel information system because the process of searching and recording personnel data is still done manually.
Totaliproductive Maintenance (Tpm) Analysis Using the Overall Equipment Effectiveness (Oee) Method and Six Big Losses on an Injection Molding Machine
Authors: Ridloi Mokhamad , Jakaria Ribangun Bamban 
Published: August 2021

. PT. XYZ is a manufacturing companyjthat produces a variety of materials from plastics, this company cangnot be separated from problems relatedhto the effectiveness of machinery / equipment. The problem that is experienced today is that there is a lot of damage to the injection moulding machine that has decreased speed as a result of the damage to the number of defect parts because the machine often experiences breakdown. Data collection is conducted with structured observations and interviews. To solve the problem that occurs, done a machine maintenance or maintenance by means of measurement using the method of Total Productive Maintenance which includes Overall Equipment Effectiveness and Six Big Losses. This study aims to determine the level of equipment total production process, to determine the factors causing the valuenof overall equipment Efectivenees (OEE) low and identify losses that occur with the standard value of
Android-Based Remote Control Solar Power Plant Panels with Direct Current System Installation
Authors: Afandi Yusril , Jamaaluddin Jamaaluddin 
Published: August 2021

Energy hot sun very overflow especially in area with climate tropical as indonesia that always exposed rays throughout years. This is a source energy that could on developed. on research aimed at to make it easier and knowing damage panel generator electric power sun more early so that soon get to do troubleshooting early before damage continue with use microcontroller NodeMCU right has been IOT designed component additional sensor INA219 gauge current, voltage, lux intensity light is snown software application BLYNK in smartphone. the results research is toll monitoring read high low battery and lamp. In the result measurement this will is snown menu application BLYNK that has been designed.
IgG4 Related Disease of The Larynx Mimicking Malignancy: A Case Report and Review of the Literature
Authors: Akyol Sevda , Saraydaroglu Ozlem , Ozmen Omer Afsin 
Published: August 2021

Abstract
Objectives: Immunoglobulin G4–related disease is characterized by increased serum IgG4 level, enlargement in the relevant organs and histopathologically intense storiform fibrosis, lymphoplasmacytic infiltration rich in IgG4 positive plasma cells, and obliterative phlebitis.Methods and Results: In this report, a patient who underwent a laryngeal biopsy with a pre-diagnosis of malignancy, but had findings consistent with immunoglobulin G4–related disease in the biopsy sample, is described.Conclusion: Immunoglobulin G4–related disease can be seen in very rare localizations. It should be kept in mind in differential diagnosis when tissues especially containing inflammation rich in plasma cells are encountered. Clinical, laboratory and pathological correlation is extremely important in the diagnosis of an IgG4-related disease.
Mothers cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rats offspring
Authors: Matuszewska Julia , Zalewski Tomasz , Klimaszyk Adam , Ziarniak Kamil , Jurga Stefan , Chmurzynska Agata , Sliwowska Joanna H. 
Published: August 2021

Abstract
“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributing to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet, in animals cafeteria (CAF) diet is used. We hypothesis that CAF diet given to rats before, during pregnancy and lactation differently influence fat content, metabolic and inflammation profiles in offspring. Female were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25) body composition, fat contents were measured, blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet leaded to sex-specific alterations in offspring. At PND25, CAF offspring had: 1) higher percentage of fat content and were lighter; 2) sex-specific differences in levels of glucose; 3) higher levels of interleukins 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); 4) sex-specific differences in concentration of IL-6 and TNF-α, with increase in CAF females; 5) higher level of IL-10 in both sex, with bigger increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.
Genome-wide Profiling of Long Non-coding RNA of the Rice Blast Fungus Magnaporthe oryzae During Infection
Authors: Choi Gobong , Jeon Jongbum , Lee Hyunjun , Zhou Shenxian , Lee Yong-Hwan 
Published: August 2021

Abstract
BackgroundLong non-coding RNAs (lncRNAs) play essential roles in developmental processes and disease development at the transcriptional and post-transcriptional levels across diverse taxa. However, only few studies have profiled fungal lncRNAs in a genome-wide manner during host infection.ResultsInfection-associated lncRNAs were identified using lncRNA profiling over six stages of host infection (e.g., vegetative growth, pre-penetration, biotrophic, and necrotrophic stages) in the model pathogenic fungus, Magnaporthe oryzae. We identified 2,601 novel lncRNAs, including 1,286 antisense lncRNAs and 980 intergenic lncRNAs. Among the identified lncRNAs, 755 were expressed in a stage-specific manner and 560 were infection-specifically expressed lncRNAs (ISELs). To decipher the potential roles of lncRNAs during infection, we identified 365 protein-coding genes that were associated with 214 ISELs. Analysis of the predicted functions of these associated genes suggested that lncRNAs regulate pathogenesis-related genes, including xylanases and effectors.ConclusionsThe ISELs and their associated genes provide a comprehensive view of lncRNAs during fungal pathogen-plant interactions. This study expands new insights into the role of lncRNAs in the rice blast fungus, as well as other plant pathogenic fungi.
Surface biofunctionalization with liquid-phase plasma treatment of collagen molecules
Authors: Tanaka Shiori , Kanemura Shingo , Okumura Masaki , Iwaikawa Kazuyuki , Funamoto Kenichi , Miyaji Godai , Muraoka Takahiro , Misawa Kazuhiko , Yoshino Daisuke 
Published: August 2021

Abstract
Surface functionalization is a key process in rendering various materials biocompatible. Whereas a number of techniques and technologies have been developed for the purpose of biofunctionalization, plasma treatment enables highly efficient surface modification. Extending plasma treatment to biomolecules in the liquid phase will control biofunctionalization via a simple process. However, interactions between plasma discharge and biomolecules or solvents are poorly understood, potentially leading to the technical limitation as to the utility of plasma treatment. In this study, we developed a technology for substrate biofunctionalization that does not require surface modification but involves direct treatment of a collagen molecules with liquid-phase plasma discharge. Biofunctionalization of collagen by plasma treatment comprises three processes that increase its reactivity with hydrophobic substrates: (1) charge-dependent changes in surface and interfacial properties of the collagen solution; (2) local conformational changes of the collagen molecules without their global structural alterations; and (3) induction of a micelle-like association formed by collagen molecules. We anticipate such plasma-induced functionalization of protein molecules to provide a versatile technique in the applications of biomaterials, including those related to pharmaceuticals and cosmetics.
Keyhole fluctuation and pore formation mechanisms during laser powder bed fusion additive manufacturing
Authors: Huang Yuze , Fleming Tristan , Clark Samuel , Marussi Sebastian , Kamel Fezzaa , Thiyagalingam Jeyan , Leung Chu Lun Alex , Lee Peter 
Published: August 2021

Abstract
Keyhole porosity is a key concern in laser powder-bed fusion (LPBF), potentially impacting component fatigue life. However, the dynamics of keyhole porosity formation, i.e., keyhole fluctuation, collapse and bubble growth and shrinkage, remain unclear. Using synchrotron X-ray imaging we reveal keyhole and bubble behaviours, quantifying their formation mechanisms. The findings support the hypotheses that: (i) keyhole porosity can initiate not only in unstable, but also transition keyhole regimes, created by high laser power-velocity conditions, causing fast radial keyhole fluctuations (~ 10 kHz); (ii) transition regime collapse tends to occur part way up the rear-wall; and (iii) immediately after keyhole collapse, the bubble grows as pressure equilibrates then shrinks due to metal-vapour condensation. Concurrent with condensation, hydrogen diffusion into the bubble slows the shrinkage and stabilises the bubble size. The physics revealed here can guide the development of real-time monitoring and control systems for keyhole porosity.
Comparative Study of Symmetrical And Asymmetrical B40 Molecular Junctions
Authors: Kaur Harleen , Kaur Jupinder , Kumar Ravinder , Vohra Rajan 
Published: August 2021

Abstract
The quantum transport in symmetric and asymmetric borospherne based molecular junction with adenine has been probed. Adenine is a nucleobase of DNA among the four nucleobases of DNA, adenine is selected because of its excellent transport properties. The DFT-NEGF mathematical approach has been utilized. This was further used to calculate quantum transport parameters such as the I-V curve, transmission spectra, highest occupied molecular orbital (HOMO)- lowest occupied molecular orbital (LUMO) gap (HLG), differential conductance, and transmission pathways. From our research work we have noticed that both symmetric and asymmetric devices exhibit non-linear behavior thus leading to non-differential resistance (NDR). Alos symmetric B40 molecular device has reduced HLG in contrast to asymmetric B40 molecular device. This drop-in HLG is due to a reduction in electron density. A high rectification ratio for the devices is observed at 0.2V. Hence symmetric and asymmetric B40 molecular junction is the potential candidates that can be utilized in future nano-scale devices.
Bioreduction and Bioremoval of Hexavalent Chromium by Genetically Engineered Strains (Escherichia Coli MT2A and Escherichia Coli MT3)
Authors: Akkurt Şeyma , Oğuz Merve , Uçkun Aysel Alkan 
Published: August 2021

Abstract
Studies on the removal of toxic metals from water by genetic engineering applications are becoming more and more diverse. Especially by the expression of cysteine and thiol rich proteins such as metallothioneins in bacterial cells, a high rate of removal of metal ions from the environment is ensured. In this study, we evaluated the removal and reduction of hexavalent chromium Cr(VI)from aqueous solutions with the recombinant strains obtained by cloning the human metallothioneinsMT2A and MT3 into Escherichia coli Jm109.E. coli MT2A was the most effective strain in both Cr(VI) removal (89%in 25 mg/L Cr(VI) application) and Cr(VI) reduction (76%in 25 mg/L Cr(VI) application).Cr(VI) adsorbed per dry cell (at 25 mg/L) were 17 mg/g, 22 mg/g and 19 mg/g for Jm109, MT2A and MT3, respectively. Scanning electron microscope (SEM) images showed that the morphological structures of Cr(VI)treated cells were significantly damaged compared to control cells. Scanning transmission electron microscope (STEM) images showed black spots in the cytoplasm of cells treated with Cr(VI).From the shifts in the Fourier transform infrared spectroscopy analysis (FTIR) spectra of the cells treated with Cr(VI) compared to the control cells, it was determined that the groups interacting with Cr were amino, hydroxyl, methyl and sulfhydryl. When all these experimental data were evaluated together, it was concluded that all three species were effective in removing Cr(VI) from aqueous solutions and MT2A strain could be used as the most effective biotechnological tool.
Global Progress Towards Sustainable Forest Management – Bright Spots and Challenges
Authors: Shono Kenichi 
Published: August 2021

Abstract
Sustainable forest management is an imperative response to continuing deforestation and forest degradation, and the associated decline in forest productivity and supply of ecosystem services. This paper analyses progress towards sustainable forest management globally as well as by climatic domains and national income levels using data from the Global Forest Resources Assessment 2020. It also examines progress towards sustainable forest management relate to the presence of enabling factors. The findings reveal global expansion of sustainable forest management supported by the widespread presence of enabling framework as manifested in the slowing rate of forest loss in large deforesting countries, increase in forest area designated for conservation, and the rapid expansion of certified forest area. However, such progress has been uneven, and the rate of forest loss is accelerating in tropical low-income countries. In addition to inadequate forest governance in general, factors contributing to this deterioration include: low coverage of long-term forest management plans; high proportion of forests without designated management objectives; and unclear ownership of forests. To enhance the implementation of sustainable forest management in these priority geographies, this paper proposes conservation through sustainable use, including strengthening the role of well-managed production forests in maintaining forest cover and ecosystem services at the landscape level.
Mode of action of Elasnin as biofilm-formation eradicator of Methicillin-Resistant Staphylococcus aureus
Authors: Long Lexin , Sulaiman Jordy Evan , Xiao Yao , Cheng Aifang , WANG Ruojun , Malit Jessie , Wong Wai , Liu Wenchao , LI Yongxin , Chen Feng , Lam Henry , Qian Pei-Yuan 
Published: August 2021

Abstract
Biofilm is made by microbes and often offers protection by making them more tolerant, resistant, and resilient to wide-range antimicrobials. Biofilm-related infections account for more than 80% of human bacterial infections and are especially prevalent in chronic tissue and device-related infections. Owing to the great challenge in treating biofilms, novel and effective antibiofilm compounds urgently need to be identified. We herein identified elasnin as a potent biofilm-targeting compound against methicillin-resistant Staphylococcus aureus (MRSA) through bioassay-guided isolation of bioactive compounds from Actinobacteria. Elasnin effectively inhibited biofilm formation and eradicated pre-formed biofilms of MRSA, and it displays low cytotoxicity with a low risk of resistance development. Transcriptomic and proteomic analyses combined with confocal microscopy observation revealed that elasnin destroyed the biofilm matrix in a time-dependent manner and interfered with cell cycle during the exponential phase, primarily by repressing the expression of virulence factors. Moreover, the biofilm cells released from elasnin treatment showed increased sensitivity to penicillin G. Overall, this study identified elasnin as a promising biofilm-eradicating compound against MRSA and shed light on its action mechanism.
Evaluation of a Residential Project in Light Steel Framing According to LEED for Homes
Authors: Morselli Luiza , Knop Stífany , Faria Osvaldo Luis Vieira , andreazza robson 
Published: August 2021

Abstract
The construction industry is responsible for high energy consumption, high carbon dioxide emissions, high extraction of non-renewable materials, and large generation of solid waste in the world.The use of prefabricated, industrialized, and technological construction methods can reduce environmental impacts.This research aimed to analyze a single-family residential project in the construction system in Light Steel Framing (LSF), to be implemented in southern Brazil, regarding the prerequisites and credits of the environmental certification Leadership in Energy and Environmental Design (LEED) for Homes of the Green Building Council (GBC) Brazil Homes.For this, it was necessary to apply the Technical Quality Regulation for the Energy Efficiency Level for Homes, achieving the A-level classification in this analysis, with 5.06 final points.Therefore, it was considered the constitution of the building wrap in LSF, the energy efficiency of the materials used, the water heating and lighting systems. The external sealing system used in the residence was the External Insulated Finish System, and the acoustic and thermal insulation occurred through the use of glass wool on the walls and lining. In order to obtain the highest level of LEED certification, the project has received suggestions for improvements. The project obtained 60 final points in the analysis, which would allow the achievement of the gold certification seal.
Exploring Chitosan-Shelled Nanobubbles to Improve HER2+ Immunotherapy Through Dendritic Cells Targeting
Authors: Argenziano Monica , Occhipinti Sergio , Scomparin Anna , Angelini Costanza , Novelli Francesco , Soster Marco , Giovarelli Mirella , Cavalli Roberta 
Published: August 2021

Abstract
Immunotherapy is a valuable approach for the treatment of cancer. Nanotechnology-based delivery systems emerged as a powerful tool for improving immunotherapeutics. Therefore, their association have been proposed to overcome some biopharmaceutical limitations of immunotherapy. This work aims at designing a novel immunotherapeutic nanoplatform for the treatment of HER2+ breast cancer. Here, purposely-tailored chitosan-shelled nanobubbles (NBs) were developed for the loading of DNA vaccine. The NBs were then functionalized with anti-CD1a antibody to target dendritic cells (DCs). The NB formulations showed sizes of about 300 nm and a good physical stability up to 6 months stored at 4 °C. The in vitro characterization confirmed that these NBs were able to load DNA with a good encapsulation efficiency (82%). The antiCD1a-functionalized NBs targeted to DCs demonstrated the capability to induce activation of DCs both in human and mouse models, and elicit a specific immune response able to delay tumor growth in vivo in mice. The results are the proof of concept that DC-targeted chitosan nanobubbles loaded with tumor vaccine may provide an attractive nanotechnology approach for the future immunotherapeutic treatment of cancer.
Frequency and Anatomic Variability of the Mandibular Lingual Foramina: A Cone-Beam CT Study
Authors: Taschieri Silvio , Corbella Stefano , Silnovic Amel , Francetti Luca , Messina Carmelo , Sconfienza Luca Maria , Albano Domenico 
Published: August 2021

Abstract
Background
to evaluate the distribution of lingual foramina (LF) and their correlation with demographic characteristics and mandible width in a series of patients subjected to cone-beam CT (CBCT).
Methods
CBCTs were reviewed to assess the number of all LF, midline and lateral LF. We also assessed the relationship of the number of lateral LF with gender and mandibular width using the Chi Square test. A p value < 0.05 was considered statistically significant.
Results
300 patients (180 males; age range: 21-87years) were included. The highest frequency per patient was of 2 LF (97/300, 32.3%), followed by 3 (81/300, 27%) and 4 (53/300, 17.7%). No LF were observed in 2/300 patients (0.7%), while the highest number was of 8 LF in one patient. The highest frequency of midline LF per person was of 2 LF (57.3%, 172/300), while the highest number per person was 5 LF in one patient (0.3%). The highest frequency of midline LF located above and below the genial tubercle was of 1 in 197/300 patients (65.7%) and in 169/300 patients (56.3%), respectively. Concerning lateral LF, the highest frequencies were of 0 (113/300, 37.7%) and of 1 (112/300, 37.3%). We did not observe any significant difference of the number of midline and lateral LF based on gender (P = .438 and P = .195, respectively) or mandible width (P = .069 and P = .114, respectively).
Conclusions
We have shown the high variability of number and anatomic distribution of LF in an Italian group of patients subjected to CBCT without reporting any association with gender and mandible width.