bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily living and rehabilitation needs in patients and caregivers affected by myeloproliferative neoplasms (MPN): A qualitative study
Authors: Rossau Henriette Knold , Kjerholt Mette , Brochmann Nana , Tang Lars Hermann , Dieperink Karin Brochstedt 
Published: July 2021

AbstractAims and ObjectivesTo explore experiences of daily living and identify rehabilitation needs in patients and caregivers living with myeloproliferative neoplasms.BackgroundMyeloproliferative neoplasms are chronic haematological cancers. Studies report a high symptom burden but little is known about supportive care and rehabilitation for this patient group.DesignQualitative study with a phenomenological approach using focus group interviews to gather knowledge about the participants' lived experiences.MethodsForty‐eight patients and seven caregivers attending a 5‐day rehabilitation course were interviewed in 12 focus groups. Systematic Text Condensation was used to analyse the interviews. Reporting adhered to COREQ.ResultsTwo main themes for patients were found: The loss of choice and identity due to the need to prioritise energy and The schism of being a person but also a patient. Patients described how living with myeloproliferative neoplasms meant having to prioritise energy and, therefore, losing freedom to choose activities. This changed their identity and impaired their quality of life. Patients of working age seemed to struggle the most in balancing the disease, family, social relationships and work. One main theme was found for caregivers: Influence of the disease. Caregivers reported how the disease limited their social lives, that the disease brought psychological strain, extra work, and that communication between couples was impaired. When both patients and caregivers participated in rehabilitation courses, they reported better understanding between couples and more open conversations. Rehabilitation needs identified were mainly in relation to psychosocial support and patient education, although needs varied across patients and caregivers.ConclusionsPatients and caregivers expressed difficulties in adjusting to the lives the disease enforced upon them. Our findings indicate that myeloproliferative neoplasms patients and their caregivers would benefit from a combined model of psychosocial support, patient education, peer support and rehabilitation interventions based on an individual needs assessment.Relevance to clinical practiceNurses can be responsible for individual needs assessments and refer patients and caregivers to suitable supportive care and rehabilitation interventions.Trial registration detailsThe study was approved by the Danish Data Protection agency (J.nr. 2008‐58‐0035).
Retrospective study evaluation of DGGR lipase for diagnosis, agreement with pancreatic lipase and prognosis in dogs with suspected acute pancreatitis
Authors: Hope A. , Bailen E. L. , Shiel R. E. , Mooney C. T. 
Published: July 2021

ObjectivesActivity of 1,2‐o‐dilauryl‐rac‐glycero‐3‐glutaric acid‐(6′‐methylresorufin) ester (DGGR) lipase is considered to be more pancreas specific than traditional lipase assays. The aim of this study was to evaluate the diagnostic performance of DGGR lipase activity for suspected acute pancreatitis in dogs and to assess its prognostic usefulness.MethodsRetrospective study of case records for suspected acute pancreatitis based on clinician‐stated diagnosis, point‐of‐care and quantitative canine pancreas‐specific lipase (cPL) results and consistent ultrasonographic features. Diagnostic performance of DGGR lipase was assessed by receiver‐operating characteristic curve analysis, agreement by Cohen's kappa (κ) and prognostic value by multiple regression analysis.ResultsMedian DGGR lipase activity was significantly (P < 0.001) higher in dogs with suspected acute pancreatitis [93.7 (range, 11.0–2853.0) U/L (n = 158)] compared to those with no evidence of pancreatitis [range, 20.9 (6.7–89.0) U/L (n = 356)]. A DGGR lipase activity >42.15 U/L had the best combined diagnostic sensitivity (81.0%) and specificity (92.1%). Previously established cut‐offs (>130 and >80 U/L) had sensitivities of 40.5 and 43.0%, and specificities of 100 and 99.7%, respectively. There was near perfect (κ = 0.821) and substantial (κ = 0.751) agreement between DGGR lipase activity >42.15 U/L and quantitative cPL concentrations ≥200 and ≥400 μg/L, respectively. DGGR lipase activity but not quantitative cPL concentration was statistically (P = 0.043, odds ratio = 0.999) predictive of discharge but clinical utility is questionable.Clinical significanceUsing DGGR lipase at the lower cut‐off could provide an additional test for supporting a diagnosis of acute pancreatitis in dogs particularly if cPL results are not available. Larger studies are required to more fully assess its value in prognostication.
Instrumentation and methods for rapid estimation of selected viscoelastic parameters in foods
Authors: Sakurai Naoki , Takashima Tatsuki , Akimoto Hidemi , Blahovec Jiří 
Published: July 2021

AbstractA new method to estimate the selected viscoelastic parameters of foods using damped vibration analysis is presented for the evaluation of fruits and baked products. A flat disk is attached to the flat sample surface using a laser rangefinder that measures the sample thickness in advance, and it is locked by a trigger. Next, the trigger is released to allow the probe to press the sample through the force of gravity. The damped vibration of the probe caused by the deformation of the food is measured by monitoring the displacement of the probe via a linear encoder. The bulk modulus and viscosity are estimated using the fractional Zener model and mass. Young's modulus (E) is estimated independently by determining the maximum velocity of the probe using Hooke's law. Poisson's ratio (ν), and the shear modulus and viscosity are calculated by employing the estimated E and bulk modulus. The bulk modulus, bulk viscosity, shear modulus, shear viscosity, and E of apples were found to be higher than those of bananas. The bulk modulus, bulk viscosity, E, and shear modulus for white bread were lower than those for pound cake, but the ν values were higher, whereas those of sponge cake were intermediate. After drying the baked products for 1 day, most of the parameters of the samples increased, but the value of ν for white bread decreased. The proposed free‐falling device estimated the four viscoelastic coefficients, Poisson's ratio, and Young's modulus of the food sample in less than 1 s.
Long‐term spatiotemporal genetic structure of an accidental parasitoid introduction, and local changes in prevalence of its associatedWolbachiasymbiont
Authors: Duplouy Anne , Nair Abhilash , Nyman Toshka , van Nouhuys Saskya 
Published: July 2021

AbstractPopulation bottlenecks associated with founder events strongly impact the establishment and genetic makeup of populations. In addition to their genotype, founding individuals also bring along parasites, as well as symbionts that can manipulate the phenotype of their host, affecting the host population establishment, dynamics and evolution. Thus, to understand introduction, invasion, and spread, we should identify the roles played by accompanying symbionts. In 1991, the parasitoid wasp,Hyposoter horticola, and its associated hyperparasitoid were accidentally introduced from the main Åland islands, Finland, to an isolated island in the archipelago, along with their host, the Glanville fritillary butterfly. Though the receiving island was unoccupied, the butterfly was present on some of the small islands in the vicinity. The three introduced species have persisted locally ever since. A strain of the endosymbiotic bacteriumWolbachiahas an intermediate prevalence in the parasitoidH.horticolaacross the main Åland population. The infection increases its susceptibility of to hyperparasitism. We investigated the establishment and spread of the parasitoid, along with patterns of prevalence of its symbiont using 323 specimens collected between 1992 and 2013, from five localities across Åland, including the source and introduced populations. Using 14 microsatellites and one mitochondrial marker, we suggest that the relatively diverse founding population and occasional migration between islands might have facilitated the persistence of all isolated populations, despite multiple local population crashes. We also show that where the hyperparasitoid is absent, and thus selection against infected wasp genotypes is relaxed, there is near‐fixation ofWolbachia.
Seven Theses on Dogmatics and Patristics in Catholic Theology☆
Authors: Ayres Lewis 
Published: July 2021

AbstractThese seven theses suggest the centrality of reflection on Patristic theology for the enterprise of dogmatic theology in a Catholic context. Dogmatic theology itself is used here as an alternative to the modern use of “systematic” theology. In order to see why and how Patristic theology should occupy this place, reflection is necessary on the theology of tradition—and the continual authority of Patristic texts for Catholic theologians—and then on the importance of post‐Renaissance modes of historiography. These discussions constitute part of a theological reflection on the nature of theology itself. Although the aim of this piece is to discuss the configuration of (Latin) Catholic theology, the questions raised should be of interest to theologians across a broad ecumenical range.
Varieties of flexibilisation? The working lives of information and communications technology professionals in the United Kingdom and Germany
Authors: Kinsella Patricia , Williams Steve , Scott Peter , Fontinha Rita 
Published: July 2021

AbstractOne feature of ‘flexibilisation’ concerns the growth of more individualised employment arrangements and career trajectories less connected to employing organisations. Informed by the Varieties of Capitalism approach, which emphasises the embeddedness of employment practices within discrete types of capitalist market economy, and based on rich qualitative data from interviews with 32 self‐employed and directly employed ICT professionals in the United Kingdom and Germany, we investigate comparative variation in their experience of flexibilisation. The research findings not only indicate some commonality, particularly in respect of perceptions of independence, but also highlight notable differences with regard to work pressures and insecurity. The paper advances theory by characterising two discrete varieties of flexibilisation, a ‘liberalised’ form evident in the United Kingdom and a more ‘regulated’ type apparent in Germany, contributing to a better understanding of comparative differences in flexibilisation.
Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies
Authors: Rouhani Parisa , Hajhashemy Zahra , Saneei Parvane 
Published: July 2021

SummaryFindings from epidemiologic studies that evaluated the relationship between serum vitamin D levels and metabolic syndrome (MetS) in children were contradictory. We conducted a systematic review and meta‐analysis on the relation of serum 25(OH)D levels and MetS in children. A comprehensive search was conducted in electronic databases, up to November 2020. Eleven cross‐sectional studies that reported the link between circulating vitamin D levels and MetS in children were included in the analysis. Combining 11 effect sizes from 11 cross‐sectional studies with 22,196 participants revealed that highest versus lowest serum vitamin D concentration was significantly associated with a 50% reduced odds of MetS in children (OR: 0.50; 95%CI: 0.39, 0.64). Subgroup analysis by study location revealed decreased odds of MetS in both non‐Asian (OR: 0.45; 95%CI: 0.33, 0.63) and Asian countries (OR: 0.54; 95%CI: 0.39, 0.76) with no heterogeneity in these subgroups. When we confined the studies to those with representative populations (n = 21,611), a significant inverse association was found between highest versus lowest circulating vitamin D level and MetS (OR: 0.55; 95%CI: 0.42, 0.71). Dose–response analysis showed that each 10 ng/ml (or 25 nmol/L) in serum vitamin D was linearly related to a 12% reduced odds of MetS (OR: 0.88; 95%CI: 0.78, 0.99) in children. A nonlinear association was also detected between serum 25(OH)D and MetS. This meta‐analysis revealed that circulating vitamin D concentration was inversely associated with odds of MetS in children, in a dose–response fashion. The same finding was found in the studies with representative populations.
Capturing nurses’ perception of communicative technologies in nursing facilities: Survey instrument development
Authors: Ali Haneen , Ahmed Abdulaziz , Cole Astin 
Published: July 2021

AbstractBackgroundDespite the common perception of the call light system as crucial for patient safety, there are usability gaps between what features staff in nursing facilities need to address an alarm quickly and how the call system is designed. A survey instrument was developed to investigate nursing home staff experiences in using call light technology.MethodsA survey instrument was developed and distributed to staff in two nursing facilities in Up‐State, New York (N= 278). The strength and direction of relationships between pairs of variables were measured using Pearson correlation and analysis of variance to investigate the perceived effect of staff's perception of the call light system on the work system's elements, process and staff outcomes.ResultsThe study found correlations between the job‐level workload and the noise in the unit (r= 0.272,p= .000), between job‐level workload and the ease of locating call lights (r= 0.154,p= .023), and between job stress and burnout (r= 0.176,p= .009). Only 64% of nursing home staff believed that the call light system reflected urgent needs, with younger staff relating to this group. The staff gave the work environment a high score, which corresponds to excessive noises caused by the call light alarm, according to 74% of the staff. These associations stem from gaps caused by a lack of user feedback in the design and acquisition process, leading to usability issues that reduce performance and satisfaction over time.ConclusionThe study found that the type of call light system used is associated with usability challenges that often impeded the performance of the nursing home staff's response to residents. These insights can improve the selection of a new call light system that avoids usability issues and challenges identified by end‐users.
Integrating genomic selection with a genotype plus genotype x environment (GGE) model improves prediction accuracy and computational efficiency
Authors: Jighly Abdulqader , Hayden Matthew , Daetwyler Hans 
Published: July 2021

AbstractGenotype‐by‐environment interaction (GEI) is one of the major factors affecting the prediction accuracy of genomic selection (GS) models. Standard models have low power to model complex GEI, and they fail to predict phenotypes in unobserved environments. Here, we developed a novel prediction model that account for GEI, named 3GS, that combines genotype plus genotype × environment (GGE) analysis with GS. The model calculates the principal components (PCs) of the environmental phenotypes using GGE analysis and predict the performance of these PCs using standard GS models before converting the GEBVs of these PCs (pcGEBVs) back to the original phenotypes. We demonstrated three advantages of the new model. First, 3GS showed significantly higher prediction accuracy primarily for deviated environments that have low to negative correlations to other environments. Second, 3GS can predict new genotypes in unobserved environments with high accuracy. Third, the computational complexity of 3GS increases linearly with increasing the number of environments and the population size, unlike the standard models that exhibit exponential increase, making it hundreds of times faster than the standard models for large data sets. 3GS can improve prediction accuracy with minimal resources in modern breeding programmes in which massive populations get multi‐environment phenotypes with high‐throughput techniques.
Establishing norms on the Japanese version of the Eyberg Child Behavior Inventory
Authors: Ito Fumie , Matano Miyuki , Kato Ikuko , Monden Yukifumi , Sunohara Yuki , Kawasaki Masako , Kimura Hitoe , Furuichi Shima , Bussing Regina , Oe Yuka , Morita Nobuaki , Kim Yoshiharu , Brestan‐Knight Elizabeth , Eyberg Sheila , Kamo Toshiko 
Published: July 2021

AbstractBackgroundThe Eyberg Child Behavior Inventory (ECBI) is one of the standardized parent rating scales used to identify disruptive behavior problems in children in Western countries. This study aimed to determine norms for the Japanese version of the ECBI, including clinical cutoff scores among the general population in Japan.MethodsThis study established norms for the Japanese version of the ECBI using a sample of 1,992 parents of children aged 2–7, living in Japan. The research evaluates the validity and the reliability of the ECBI scores for the Intensity Scale and the Problem Scale. After validation, a clinical cutoff value of the ECBI scores was calculated, setting the cutoff to above the +1 standard deviation (SD) level based on the population distribution.ResultsThe means of the Intensity and Problem Scale scores were 100.07 and 6.57, respectively. Cronbach's α for both the Intensity and the Problem scores was 0.91. At this point, we propose cutoff scores of 125 for the Intensity Scale and 14 for the Problem Scale.ConclusionsOur results suggest that the Japanese version of the ECBI is highly reliable and may be useful as a tool for assessing behavior problems in children.
Contrived self‐defense: A case of permissible wrongdoing
Authors: Ho Tsung‐Hsing 
Published: July 2021

AbstractIt is widely held that a morally wrong action is morally impermissible. I discuss a case of contrived self‐defense and argue that it is morally both wrong and permissible. I compare it with other kinds of morally permissible misbehavior (suberogation, moral dilemma, and right to do wrong) and show that it is significant and original.
Twenty years with the public health intervention wheel: Evidence for practice
Authors: Schaffer Marjorie A. , Strohschein Susan , Glavin Kari 
Published: July 2021

AbstractThe Public Health Intervention Wheel (PHI Wheel) is a population‐based practice model for public health nursing practice that encompasses three levels of practice (community, systems, individual/family) and 17 public health interventions. This article shares the story of how the PHI Wheel was created, disseminated, implemented by public health nurses (PHNs) and educators across the globe, and updated with new evidence published in the second edition of Public Health Interventions: Applications for Public Health Nursing in 2019. Evidence on the relevance of PHI Wheel interventions for public health practice in cultural and international settings supports the model's value in explaining PHN practice. This article highlights the experiences of various countries with the PHI Wheel including Canada, Ireland, New Zealand, Norway, Sweden, the United Kingdom, and the United States. The evidence update confirms the relevance of the model to PHN education and practice and reinforces the conviction that development of new evidence is essential for promoting population health.
CD163‐positive cancer cells are a predictor of a worse clinical course in lung adenocarcinoma
Authors: Matsubara Eri , Komohara Yoshihiro , Shinchi Yusuke , Mito Remi , Fujiwara Yukio , Ikeda Koei , Shima Toshiyuki , Shimoda Masayuki , Kanai Yae , Sakagami Takuro , Suzuki Makoto 
Published: July 2021

AbstractCD163 is one of the scavenger receptors expressed on macrophages. However, several immunohistochemical studies have demonstrated that CD163 is also detected on cancer cells, and is associated with a poor prognosis. In the present study, we detected CD163 staining on cancer cells in lung adenocarcinoma and squamous cell carcinoma (SCC), and investigated the relationship between CD163 on cancer cells and the clinical prognosis. CD163 staining was seen in 128 of 342 adenocarcinoma cases and 35 of 103 SCC cases. Among the lung adenocarcinoma cases, the progression‐free survival and overall survival were significantly shorter in the CD163 high group than the CD163 low group. A similar trend was observed among the SCC cases, but the difference was not statistically significant. Additionally, a higher number of macrophages was detected in areas with CD163‐positive cancer cells when compared to areas with CD163‐negative cancer cells. In summary, we found that CD163‐positive cancer cells are a predictor of a worse clinical course in lung adenocarcinoma and SCC.
Inference About Complex Relationships Using Peak Height Data from DNA Mixtures
Authors: Green Peter J. , Mortera Julia 
Published: July 2021

AbstractIn both criminal cases and civil cases, there is an increasing demand for the analysis of DNA mixtures involving relationships. The goal might be, for example, to identify the contributors to a DNA mixture where the donors may be related, or to infer the relationship between individuals based on a mixture. This paper introduces an approach to modelling and computation for DNA mixtures involving contributors with arbitrarily complex relationships. It builds on an extension of Jacquard's condensed coefficients of identity, to specify and compute with joint relationships, not only pairwise ones, including the possibility of inbreeding. The methodology developed is applied to two casework examples involving a missing person, and simulation studies of performance, in which the ability of the methodology to recover complex relationship information from synthetic data with known ‘true’ family structure is examined. The methods used to analyse the examples are implemented in the new KinMix R package that extends the DNAmixtures package to allow for modelling DNA mixtures with related contributors.
Response-Adaptive Rerandomization
Authors: Zhang Hengtao , Yin Guosheng 
Published: July 2021

Abstract
Rerandomization has recently attracted more attention in the literature randomized experiments. It leverages covariate information of participants to achieve a well-balanced allocation, and thus improves the efficiency of inference. However, by only considering covariate information, it may lead to potential ethical issues in clinical trials as a large number of patients might be assigned to the inferior treatment arm. To mitigate this issue, we propose a response-adaptive rerandomization scheme by incorporating response information for two-arm comparative clinical trials. Not only is our method applicable to both continuous and binary outcomes, but it also demonstrates desirable statistical and ethical properties. Extensive simulation studies are performed to illustrate the practicality and superiority of our approach.