bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metanálise de pesquisas sobre inundações urbanas: identificação de fatores causais e métodos empregados em estudos recentes
Authors: Simas Iury Tadashi Hirota , Rodrigues Cleide , Cazaroto Pamela Cristina , Rodrigues Breno Schmidtke 
Published: October 2021

No contexto de pesquisa mais ampla, com foco na investigação de fatores causais para ocorrências de inundações nas bacias urbanizadas de São Paulo, foi realizada pesquisa de metanálise sobre estudos que enfocaram inundações urbanas em diferentes perspectivas de análise dos campos do conhecimento correlatos (geomorfologia, climatologia, hidrologia, etc.). Buscou-se identificar relações entre conceitos mais associados, metodologias mais empregadas e fatores causais mais apontados. A metanálise foi realizada em duas etapas: uma mais extensiva, sobre base mundial de periódicos Web of Science, e uma de maior detalhe, sobre bases nacionais de periódicos e repositórios de teses e dissertações. Os dados da primeira etapa foram analisados por meio de mapeamento bibliométrico e os da segunda foram fichados e analisados qualitativamente. A representatividade de pesquisas sobre inundações urbanas com origem em países do meio tropical foi considerada significativamente baixa. Na subárea da climatologia e meteorologia, identificou-se preponderância da associação de “inundações” às mudanças climáticas, enquanto na geomorfologia e geociências em geral, a associação mais comum ocorre entre a variável hidrológica do escoamento superficial e a impermeabilização urbana. Dentre as produções nacionais, as pesquisas são mais comumente desenvolvidas utilizando técnicas de geoprocessamento e pesquisa histórica-documental, enquanto o uso de modelagem é dominante apenas na área da hidrologia. Os resultados corroboram com a hipótese original de trabalho, que considerou que as diferentes áreas do conhecimento diferem nas metodologias para abordagem do problema e, portanto, na identificação de variáveis causais, raramente considerando aquelas menos usuais em sua abordagem.
The Holy Sinful Church: Towards a More Realistic Catholic Ecclesiology
Authors: Porada Rajmund 
Published: October 2021

Abstract
This article demonstrates that in Roman Catholic ecclesiology, it would be more justifiable and realistic to fully accept the concept of the sinfulness of the Church as a whole, not only that of its individual members. The piece begins with a short review and commentary on the doctrinal position of the Second Vatican Council (1962–1965) that provides a doctrinal basis for adopting and developing the notion of a ‘sinful Church’. Then, two contemporary activities of the Roman Catholic Church are analysed in which the notion of the ‘sinful Church’ has played an important role: the Great Jubilee act of confession, with the related explanations and commentaries, and the ecumenical dialogue with Lutherans. The final section attempts to formulate some suggestions for a more realistic Catholic ecclesiology involving a ‘relativisation’ of the Church’s salvific mission and a wider use of the Chalcedonian Christological paradigm in ecclesiology.
Gallic acid inhibits celecoxib-induced mitochondrial permeability transition and reduces its toxicity in isolated cardiomyocytes and mitochondria
Authors: Salimi A , Atashbar S , Shabani M 
Published: October 2021

Background: Mitochondria are the main target organelles through which drugs and chemicals exert their toxic effect on cardiomyocytes. The mitochondria-related mechanisms of celecoxib-induced cardiotoxicity have been extensively studied. Accumulated evidence shows natural molecules targeting mitochondria have proven to be effective in preventing cardiotoxicity. Purpose: In the present study, we examined the ameliorative effect of gallic acid (GA) against celecoxib-induced cellular and mitochondrial toxicity in isolated cardiomyocytes and mitochondria. Research Design: The isolated cardiomyocytes and mitochondria were divided into various group, namely, control, celecoxib, celecoxib + GA (10, 50, and 100 µM). Several cellular and mitochondrial parameters such as cell viability, lipid peroxidation, succinate dehydrogenase (SDH) activity, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, and mitochondrial swelling were assessed in isolated cardiomyocytes and mitochondria. Results: Our results showed that administration of celecoxib (16 µg/ml) induced cytotoxicity and mitochondrial dysfunction at 6 h and 1 h, respectively, which is associated with lipid peroxidation intact cardiomyocytes, mitochondrial ROS formation, MMP collapse, and mitochondrial swelling. The cardiomyocytes and mitochondria treated with celecoxib + GA (10, 50, and 100 µM) significantly and dose-dependently restore the altered levels of cellular and mitochondrial parameters. Conclusions: We concluded that GA through antioxidant potential and inhibition of mitochondrial permeability transition (MPT) pore exerted ameliorative role in celecoxib-induced toxicity in isolated cardiomyocytes and mitochondria. The data of the current study suggested that GA supplementation may reduce celecoxib-induced cellular and mitochondrial toxicity during exposure and may provide a potential prophylactic and defensive candidate for coxibs-induced mitochondrial dysfunction, oxidative stress, and cardiotoxicity.
Association of the premature immunosenescence with the presence and severity of anemia among patients with systemic lupus erythematosus
Authors: Handono Kusworini , Wahono Cesarius Singgih , Pratama Mirza Zaka , Kalim Handono 
Published: October 2021

Introduction One of the possible mechanisms that contribute to the development of anemia in systemic lupus erythematosus (SLE) is the presence of premature immunosenescence in SLE. This study aimed to observe the correlation between immunosenescence with anemia in SLE. Methods This research was a cross-sectional study with the subject was 60 women with SLE aged 16–45 years old. Subjects were recorded for the demographic and clinical data, complete blood counts, iron status (iron serum, total iron-binding capacity, and transferrin saturation), ferritin, inflammatory markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]), and anti-dsDNA levels. Immunosenescence was observed by measuring the senescent T cells from peripheral blood mononuclear cells (PBMC) by flow cytometry, counted as CD4+CD57+ and CD8+CD57+ T cells. Serum IL-2 and IFNγ as the cytokines associated with immunosenescence were also measured from all subjects. Subjects were divided into anemic and non-anemic groups according to the classification of anemia from WHO (Hb < 12 gr/dl). Results Anemic SLE patients had higher CD4+CD57+, CD8+CD57+, and IFNγ, while IL-2 was lower in SLE patients with anemia. Multivariate linear regression revealed that the decreasing levels of Hb were associated with the increase of CD8+CD57+ percentages and IFNγ levels. Anti-dsDNA, ESR, CRP, ferritin, iron serum, and transferrin saturation were correlated with CD8+CD57+. IFNγ level also correlated with the anti-dsDNA, iron serum, and ferritin levels. No correlation was found between the iron status and inflammatory markers with CD4+CD57+ percentages and IL-2 levels. Multivariate regression analysis showed that IFNγ was positively associated with anti-dsDNA and negatively associated with iron serum and transferrin saturation, while CD8+CD57+ percentages were positively associated with the ferritin levels. Conclusion Immunosenescence is associated with anemia by modulating the inflammatory response and causing iron dysregulation in SLE.
Dissociation in SLE: A part of lupus fog?
Authors: Monahan Rory C , Blonk Anne ME , Baptist Esther , Middelkoop Huub AM , Kloppenburg Margreet , Huizinga Tom WJ , van der Wee Nic J , Steup-Beekman Gerda M 
Published: October 2021

Introduction Lupus fog is ill-defined. We aimed to study whether lupus fog is the result of dissociation by studying the prevalence of dissociation and dissociative fog in patients with SLE and neuropsychiatric manifestations of inflammatory and non-inflammatory origin. Methods Patients visiting the tertiary referral center for neuropsychiatric systemic lupus erythematosus (NPSLE) of the LUMC between 2007–2019 were included. Patients were classified as having neuropsychiatric symptoms of inflammatory or non-inflammatory origin. Dissociation was studied using the Dissociative Experience Scale-II (DES), in which the presence of 28 dissociative symptoms is rated (0–100% of the time), of which one question assesses the presence of a dissociative fog directly. Average scores are calculated and scores ≥ 25 are considered indicative of a dissociative disorder. A score of ≥ 30 on question 28 (dissociative fog) was considered indicative for the presence of a fog. Summary scores in the general adult population range from 4.4 to 14. Multiple regression analysis (MRA) was performed to study the association between inflammatory neuropsychiatric symptoms and dissociation. DES results are presented as median (range) and MRA as B and 95% confidence interval (CI). Results DES questionnaires were available for 337 patients, of which 69 had an inflammatory NPSLE phenotype (20%). Mean age in the total study population was 43 ± 14 years and the majority was female (87%). The median dissociation score was 7.1 (0–75) and did not differ between patients with neuropsychiatric symptoms of inflammatory or non-inflammatory origin (B: −0.04 (95% CI: −0.17; 0.09)). 35 patients (10%) had a score indicative of a dissociative disorder. The most common type of dissociation was absorption/imagination. 43 patients (13%) reported a dissociative fog. Discussion In most patients with SLE and neuropsychiatric symptoms, dissociative symptoms are within normal range, regardless of underlying etiology. Dissociative fog is present, but uncommon. Lupus fog is most likely not associated with dissociation.
Long-term visual, anterior and posterior corneal changes after crosslinking for progressive keratoconus
Authors: Salman Abdelrahman , Ali Ali , Rafea Shaaban , Omran Rana , Kubaisi Buraa , Ghabra Marwan , Darwish Taym 
Published: October 2021

Aim To evaluate the long-term outcomes of corneal cross-linking (CXL) in patients with progressive keratoconus. Method In this retrospective non-comparative study, forty-five eyes of 31 patients with progressive keratoconus were treated with 30 min “epi-off” corneal cross-linking. The visual, refractive, topographic and tomographic outcomes were evaluated preoperatively and at least 10 years after cross-linking. Results Ten years post-corneal cross-linking, the mean anterior maximum keratometry decreased (−2.10 ± 3.25 D, P = 0.0001). Conversely, the posterior maximum keratometry increased (6.38 ± 9.79 D, P = 0.065). Both uncorrected and corrected distance visual acuity improved (LogMAR −0.08 ± 0.30) and (LogMAR −0.05 ± 0.21), respectively (P > 0.05, both). A statistically significant hyperopic shift was observed postoperatively (0.70 ± 1.31 D, P = 0.0009). The anterior topographic cylinder values revealed no change (−0.17 ± 1.31 D, P = 0.3), whereas the mean posterior cylinder values decreased (absolute value increased) significantly compared to baseline from −1.31 ± 0.97 D to −1.82 ± 1.78 D, (P < 0.05). The minimum corneal thickness values decreased significantly (−35.11 ± 48.63 µm, P = 0.0001). Four eyes (8.8%) showed more than 1 D increase in the anterior maximum keratometry. Conclusion This protocol and duration of Epi-off corneal cross-linking was found to be effective in halting keratoconus progression over the follow up period (10 years). Anterior corneal flattening and a hyperopic shift were observed. A statistically significant increase in the posterior corneal cylinder was observed. Although, not reaching statistical significance, the logMAR uncorrected and corrected visual acuity were improved.
On the Association Between Trauma-Related Shame and Symptoms of Psychopathology: A Meta-Analysis
Authors: DeCou Christopher R. , Lynch Shannon M. , Weber Shelby , Richner Danielle , Mozafari Ahva , Huggins Holly , Perschon Bailey 
Published: October 2021

Background A number of studies have identified significant associations between trauma-related shame and psychopathology including posttraumatic stress disorder (PTSD), dissociation, and depression. The aim of this paper was to assess the extent to which trauma-related shame is associated with psychological distress across populations (e.g., veterans, college students, women, clinical samples) and offer via meta-analyses a preliminary conclusion about the importance of assessing trauma-related shame. Methods Records in Academic Search Complete, MedLine, MedLine Complete, PILOTS, PsycINFO, PsychTests, and PubMed were reviewed. Authors identified 25 studies that met the following inclusion criteria: (1) reported findings of an empirical study with quantitative results; (2) included any measurement of a trauma-related shame; and (3) included any measure of psychological distress or psychological symptoms. Data were extracted using a structured protocol, and random effects meta-analyses were calculated. Findings There were moderate weighted mean correlations between trauma-related shame and symptoms of psychopathology (r = 0.44), trauma-related distress (r = 0.49), and depression (r = 0.35). There was significant heterogeneity among studies. Neither study quality nor sample characteristics were significant moderators. Conclusion This meta-analysis demonstrated robust associations between trauma-related shame and symptoms of psychopathology broadly as well as trauma-related distress and depression. The findings underscore the importance of explicitly assessing trauma-related shame as part of standard care for trauma survivors who present for treatment. Several treatments explicitly address the role of shame and have demonstrated efficacy for reducing symptoms of trauma-related distress.
Plastic and aesthetic surgery among medical students: A cross-sectional study
Authors: Alyahya Tareq , Zakaria Ossama Mohamed , Al Jabr Faisal Ali , Alshaikhmubarak Saif Fahad , Nidal Abdulla , Abdulwahab Ahmed , Sakan Noor , Alarfaj Ahmad Sami , Al Furaikh Bashayer Fawaz 
Published: October 2021

Objectives: The wide variety of operations that a plastic surgeon can deal with creates confusion regarding its proper scope. This confusion was observed in primary physicians as well as medical students. Increasing the perception of medical students toward plastic surgery can aid in career decision-making and early referral patterns. The aim of this study is to gauge a holistic overview of how medical students and interns perceive the plastic and aesthetic surgical specialty in King Faisal University and to suggest a recommended plan. Methods: An online questionnaire was distributed equally to male and female medical students and interns in a local medical institute. The questionnaire constituted three sections; the first included the biographical data. The second is concerned with the different case scenarios and specialties to be chosen. The third is concerned with the previous clinical exposures. The data were analyzed by SPSS version 21. Between comparison, chi-square tests, Mann–Whitney U-test, and Kruskal–Wallis tests were applied. Normality tests were conducted using the Shapiro–Wilk’s test. Results: Two hundred ninety-two students and interns have participated and completed the questionnaire. There were 189 males and 103 females. Plastic surgery was most commonly chosen in the following case scenarios; burn of the hand (74%), broken nose (64.7%), and cosmetic nose reshaping (80.8%). However, plastic surgery was infrequently chosen (selected by <30% of students) in many areas of hands and peripheral neuropathies (severed finger extensor tendon (26.4%), fractured scaphoid (12.7%), carpal tunnel syndrome (14.4%), brachial plexus injury (16.1%)). The most common source of information was the social media, and the least one is meeting with doctors and professors. Conclusion: Medical students and interns lack a full view of plastic and reconstructive surgery, especially in hand and peripheral neuropathies. Improving the education of medical students and interns is recommended and needed.
Impact attenuation provided by older adult protective headwear products during simulated fall-related head impacts
Authors: Martel Daniel R , Tanel Michelle R , Laing Andrew C 
Published: October 2021

Introduction While protective headwear products (PHP) are designed to protect older adults from fall-related head injuries, there are limited data on their protective capacity. This study’s goal was to assess the impact attenuation provided by commercially available PHP during simulated head impacts. Methods A drop tower and Hybrid III headform measured the decrease in peak linear acceleration ( g atten) provided by 12 PHP for front- and back-of-head impacts at low (clinically relevant: 3.5 m/s) and high (5.7 m/s) impact velocities. Results The range of g atten across PHP was larger at the low velocity (56% and 41% for back and frontal impacts, respectively) vs. high velocity condition (27% and 38% for back and frontal impacts, respectively). A significant interaction between impact location and velocity was observed ( p < .05), with significantly greater g atten for back-of-head compared to front-of-head impacts at the low impact velocity (19% mean difference). While not significant, there was a modest positive association between g atten and product padding thickness for back-of-head impacts ( p = .095; r = 0.349). Conclusion This study demonstrates the wide range in impact attenuation across commercially available PHP, and suggests that existing products provide greater impact attenuation during back-of-head impacts. These data may inform evidence-based decisions for clinicians and consumers and help drive industry innovation.
Gender Disparity Among NBA and WNBA Team Physicians (112)
Authors: Mulcahey Mary , Hinkle Andrew , Brown Symone 
Published: October 2021

Objectives: Female physicians are underrepresented across a broad range of medical specialties, especially at senior levels. Previous research demonstrated poor representation of women in sports medicine leadership roles in the National Collegiate Athletic Association (NCAA) compared to their male colleagues. The purpose of this study was to evaluate the distribution of men and women among team physicians on the medical staffs of National Basketball Association (NBA) and Women’s National Basketball Association (WNBA) teams in the last 10 years and assess regional differences in representation of female physicians. Methods: A Google search of publicly available data regarding team physician gender, medical specialty, and medical degree was conducted in October 2019 for team physicians in the NBA and WNBA over the last 10 years. Descriptive statistics were used to analyze the data. This data was then stratified by region of country in which NBA/WNBA franchises are located to provide regional comparison of team physician characteristics. Results: We identified 125 team physicians for NBA franchises. 122 (97.6%) were male and 3 (2.4%) were female. In the WNBA, a total of 28 physicians were identified. 20 (71.4%) were male and 8 (28.6%) were female. Osteopathic physicians accounted for 5 (4%) and 2 (7.1%) of the physicians associated with NBA and WNBA franchises, respectively. Demographic findings of NBA and WNBA team physicians are demonstrated in Table 1. The Northeast had the highest proportion of female team physicians, with 5 of 18 (27.8%). Conclusions: This study demonstrates a substantial difference in the number of female physicians with leadership roles in both the NBA and WNBA compared to male physicians. It is important to try to understand what barriers female physicians face in their pursuit of leadership positions in sports medicine and to implement strategies to provide equal opportunities to both male and female physicians.
How Well Does MRI Predict Chondral Lesions in Patients with Femoroacetabular Impingement? An Analysis of 545 Cases (137)
Authors: Hagen Mia , Hannay William , Saluan Quinn , Lynch T. Sean , Westermann Robert , Rosneck James 
Published: October 2021

Objectives: Articular cartilage injury has been identified as a risk factor for poor outcomes following hip arthroscopy for femoroacetabular impingement syndrome (FAI). The purpose of this study was to evaluate the efficacy of magnetic resonance imaging (MRI) in detecting cartilage defects, and to identify specific MRI findings associated with cartilage injury. Methods: All patients undergoing hip arthroscopy between February 2015 and May 2017 at one institution were enrolled in a prospective cohort. Intra-articular findings were documented at the time of surgery. MRI reports were retrospectively reviewed for radiologist-reported articular cartilage, osseous or synovial abnormalities. Sensitivity and specificity of MRI findings were calculated; multivariate logistic regression analysis determined which findings were associated with high-grade chondral damage at time of arthroscopy and used to create an online risk calculator, https://orthop.washington.edu/hiprisk/. Results: Out of a total of 598 patients who underwent hip arthroscopy, 550 had MRI reports available for review (92%). Grade III and IV cartilage injuries were reported on arthroscopy in 70 patients (13%) of average age 33 ± 13 years. On univariate analyses, individual MRI findings were not found to be sensitive in detection of articular cartilage injury (mean 22%, range 1.4% – 46%), but positive findings were highly specific (mean 90%, range 76% – 99%). Multivariate analysis revealed that older age (OR 1.09 [1.06-1.11], p < .001) and osseous findings such as subchondral cyst or edema (OR 4.77 [2.51-9.05], p <.001) were most predictive of grade III and IV defects (p < .001). An example of use of the online calculator is in Figure 1. Conclusions: MRI was a specific but not sensitive tool in diagnosing articular cartilage injury. Surgeons should be aware that osseous findings such as cysts or edema are highly predictive of full-thickness cartilage loss in FAI.
Soft Tissue CAM Impingement in Adolescents: MRI reveals impingement lesions underappreciated on x-ray (138)
Authors: Johnson Benjamin , Youngman Tyler , Ellis Henry , Morris William , Sucato Daniel , Podeszwa David 
Published: October 2021

Objectives: The presence of femoroacetabular impingement (FAI) in adolescents has been established. However, the existence of a non-ossified CAM lesion in adolescent femoracetabular impingement (FAI) is not well described. The purpose of this study is to evaluate the presence of a non-ossified or soft CAM lesion in adolescent patients with FAI. Methods: A review of a prospective cohort of patients with symptomatic FAI in an institutional registry was performed. Subjects were included if they had an MRI and lateral x-ray of the hip (45o Dunn, Cross Table, or frog) at a baseline visit. On MRI, evaluation of the anterolateral femoral head was evaluated using radial, coronal, sagittal, or axial oblique sequences. When a soft CAM lesion was identified (all found between 2-5 o’clock), an alpha angle was performed on MRI and plain radiograph. The cohort of soft CAM lesions was reviewed and differences between radiographic and MRI alpha angles were assessed using a paired T-Test. Results: Thirty-one (9.3%) of 332 hips (mean age 16.4 yrs, range 13.66-19.59 yrs; 83.9% F) were identified with a soft impinging lesion at the femoral head-neck junction on MRI. The most common primary sport was track & field (4), the average duration of symptoms was 92.4 weeks and a majority with insidious onset (77.4%). The average alpha angle on MRI was greater than on x-ray [63.53 ± 7.94o vs 51.25 ± 7.92o; p<.05]. All subjects with soft CAM lesions demonstrated soft tissue consistent with extension of the physis (n=1),thickening of the peri-chondral ring (n=22), or thickening of the periosteum (n=8). Twenty-two of these patients (71%) with soft impingement underwent hip preservation surgery (n=13 labral repairs) with improvements in clinical outcome. Conclusions: In adolescent patients with symptomatic hip impingement, MRI may be useful to identify soft CAM lesions (non-ossified) that are under-represented on x-ray.