bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term outcome of isolated lateral malleolar fracture treatment is independent of hospital trauma volume or teaching status: a nationwide retrospective cohort study
Authors: Vehling Malte , Canal Claudio , Ziegenhain Franziska , Pape Hans-Christoph , Neuhaus Valentin 
Published: August 2021

Abstract
Introduction
In light of current discussions about centralisation and teaching in medicine, we wanted to investigate the differences in in-hospital outcomes after surgical treatment of isolated ankle fractures, taking into account high-volume centres (HVCs) and low-volume centres (LVCs) and teaching procedures.

Methods
A retrospective analysis of malleolar fractures recorded in a National Quality Assurance Database (AQC) from the period 01-01-1998 to 31-12-2018 was carried out. Inclusion criteria were isolated, and operatively treated lateral malleolar fractures (ICD-10 Code S82.6 and corresponding procedure codes). Variables were sought in bivariate and multivariate analyses. A total of 6760 cases were included. By dividing the total cases arbitrarily in half, 12 HVCs (n = 3327, 49%) and 56 LVCs (n = 3433, 51%) were identified.

Results
Patients in HVCs were younger (48 vs. 50 years old), had more comorbidities (26% vs. 19%) and had more open fractures (0.48% vs. 0.15%). Open reduction and internal fixation was the most common operative treatment at HVCs and LVCs (95% vs. 98%). A more frequent use of external fixation (2.5% vs. 0.55%) was reported at HVCs. There was no difference in mortality between treatment at HVCs and LVCs. A longer hospitalisation of 7.2 ± 5 days at HVCs vs. 6.3 ± 4.8 days at LVCs was observed. In addition, a higher rate of complications of 3.2% was found at HVCs compared to 1.9% at LVCs. The frequency of teaching operations was significantly higher at HVCs (30% vs. 26%). Teaching status had no influence on mortality or complications but was associated with a prolonged length of stay and operating time.

Conclusion
We found significant differences between HVCs and LVCs in terms of in-hospital outcomes for ankle fractures. These differences could be explained due to a more severely ill patient population and more complex (also open) fracture patterns with resulting use of external fixation and longer duration of surgery. However, structural and organisational differences, such as an extended preoperative stays at HVCs and a higher teaching rate, were also apparent. No difference in mortality could be detected.
Chow groups and pseudoffective cones of complexity-one T-varieties
Authors: Nødland Bernt Ivar Utstøl 
Published: August 2021

AbstractWe show that the pseudoeffective cone of k-cycles on a complete complexity-one T-variety is rational polyhedral for any k, generated by classes of T-invariant subvarieties. When X is also rational, we give a presentation of the Chow groups of X in terms of generators and relations, coming from the combinatorial data defining X as a T-variety.
Transient Ignition of Premixed Methane/Air Mixtures by a Pre-chamber Hot Jet: a DNS Study
Authors: Chi Cheng , Abdelsamie Abouelmagd , Thévenin Dominique 
Published: August 2021

AbstractThe present study investigates the transient processes controlling ignition by a hot jet issued from a pre-chamber. Direct numerical simulations (DNS) have been performed to study the characteristics of the turbulent jet flow and of the associated flame during the whole ignition process, quantifying the relevant physicochemical interactions between pre-chamber and main chamber. Thanks to a detailed analysis of the DNS results, the transient ignition is found to consist of three main sequential processes: (1) near-orifice local ignition in the main chamber; (2) further flame development supported by the jet flow; and (3) global ignition and propagation of a self-sustained flame in the main chamber, independently from the hot jet. The characteristic time-scale of the hot jet as well as jet-induced effects (local enrichment, supply of radicals and heat) are found to be essential for successful ignition in the main chamber. A more intense turbulence in the main chamber appears to support local ignition. However, it also induces local quenching, thus delaying global ignition. An ignition threshold based on a critical Damköhler number is a promising concept, but is not sufficient to describe the process in all its complexity.
Turning scientific serendipity into discoveries in breast cancer research and treatment: a tale of PhD students and a 50-year roaming tamoxifen team
Authors: Jordan V. Craig 
Published: August 2021

Abstract
Purpose
This retrospective, about a single “mobile” laboratory in six locations on two continents, is intended as a case study in discovery for trainees and junior faculty in the medical sciences. Your knowledge of your topic is necessary to expect the unexpected.

Historical method
In 1972, there was no tamoxifen, only ICI 46, 474, a non-steroidal anti-estrogen with little chance of clinical development. No one would ever be foolish enough to predict that the medicine, 20 years later, would achieve legendary status as the first targeted treatment for breast cancer, and millions of women would benefit from long-term adjuvant tamoxifen therapy. The secret of tamoxifen’s success was a translational research strategy proposed in the mid 1970’s. This strategy was to treat only patients with estrogen receptor (ER)-positive breast cancer and deploy 5 or more years of adjuvant tamoxifen therapy to prevent recurrence. Additionally, tamoxifen prevented mammary cancer in animals. Could the medicine prevent breast cancer in women?

Results
Tamoxifen and the failed breast cancer drug raloxifene became the first selective estrogen receptor modulators (SERMs): a new drug group, discovered at the University of Wisconsin, Comprehensive Cancer Center. Serendipity can play a fundamental role in discovery, but there must be a rigorous preparation for the investigator to appreciate the possibility of a pending discovery. This article follows the unanticipated discoveries when PhD students “get the wrong answer.” The secret of success of my six Tamoxifen Teams was their technical excellence to create models, to decipher mechanisms, that drove the development of new medicines.

Summary of advances
Discoveries are listed that either changed women’s health or allowed an understanding of originally opaque mechanisms of action of potential therapies. These advances in women’s health were supported entirely by government-sponsored peer-reviewed funding and major philanthropy from the Lynn Sage Breast Cancer Foundation, the Avon Foundation, and the Susan G. Komen Breast Cancer Foundation. The resulting lives saved or extended, families aided in a time of crisis and the injection of billions of dollars into national economies by drug development, is proof of the value of Federal or philanthropic investment into unencumbered research aimed at saving millions of lives.
A multi-source entity-level sentiment corpus for the financial domain: the FinLin corpus
Authors: Daudert Tobias 
Published: August 2021

AbstractWe introduce FinLin, a novel corpus containing investor reports, company reports, news articles, and microblogs from StockTwits, targeting multiple entities stemming from the automobile industry and covering a 3-month period. FinLin was annotated with a sentiment score and a relevance score in the range [− 1.0, 1.0] and [0.0, 1.0], respectively. The annotations also include the text spans selected for the sentiment, thus, providing additional insight into the annotators’ reasoning. Overall, FinLin aims to complement the current knowledge by providing a novel and publicly available financial sentiment corpus and to foster research on the topic of financial sentiment analysis and potential applications in behavioural science.
MultiETSC: automated machine learning for early time series classification
Authors: Ottervanger Gilles , Baratchi Mitra , Hoos Holger H. 
Published: August 2021

AbstractEarly time series classification (EarlyTSC) involves the prediction of a class label based on partial observation of a given time series. Most EarlyTSC algorithms consider the trade-off between accuracy and earliness as two competing objectives, using a single dedicated hyperparameter. To obtain insights into this trade-off requires finding a set of non-dominated (Pareto efficient) classifiers. So far, this has been approached through manual hyperparameter tuning. Since the trade-off hyperparameters only provide indirect control over the earliness-accuracy trade-off, manual tuning is tedious and tends to result in many sub-optimal hyperparameter settings. This complicates the search for optimal hyperparameter settings and forms a hurdle for the application of EarlyTSC to real-world problems. To address these issues, we propose an automated approach to hyperparameter tuning and algorithm selection for EarlyTSC, building on developments in the fast-moving research area known as automated machine learning (AutoML). To deal with the challenging task of optimising two conflicting objectives in early time series classification, we propose MultiETSC, a system for multi-objective algorithm selection and hyperparameter optimisation (MO-CASH) for EarlyTSC. MultiETSC can potentially leverage any existing or future EarlyTSC algorithm and produces a set of Pareto optimal algorithm configurations from which a user can choose a posteriori. As an additional benefit, our proposed framework can incorporate and leverage time-series classification algorithms not originally designed for EarlyTSC for improving performance on EarlyTSC; we demonstrate this property using a newly defined, “naïve” fixed-time algorithm. In an extensive empirical evaluation of our new approach on a benchmark of 115 data sets, we show that MultiETSC performs substantially better than baseline methods, ranking highest (avg. rank 1.98) compared to conceptually simpler single-algorithm (2.98) and single-objective alternatives (4.36).
Globular adiponectin inhibits osteoblastic differentiation of vascular smooth muscle cells through the PI3K/AKT and Wnt/β-catenin pathway
Authors: Zhou Yun , Wei Li-Long , Zhang Rui-Ping , Han Cheng-Wu , Cao Yongtong 
Published: August 2021

AbstractLipid metabolism is closely related to the improvement of vascular calcification (VC) in chronic kidney disease (CKD). Globular adiponectin (gAd) has been reported to be involved in the development of VC in CKD, but the detailed regulatory role remains unclear. The present study is aimed to investigate the biological function and the underlying regulation mechanism of gAd in the process of VC during CKD. Vascular smooth muscle cells (VSMCs) calcification was determined by Alizarin Red S staining. Protein signaling related with VC was tested by western blotting. The expression and intracellular localization of runt-related transcription factor 2 (Runx2) was detected by immunofluorescence and uraemic rat with VC was established by a two-step nephrectomy. Combined with the results of Alizarin Red S staining, we discovered that β-glycerophosphate (β-Gp)-induced the osteoblastic differentiation of VSMCs was significantly reversed by gAd treatment. Along with the VSMCs calcification and the increase of Runx2 in β-Gp-exposed VSMCs, the activities of protein kinase B (AKT) and Wnt/β-catenin pathway were enhanced, but that were counteracted by the exposure of gAd in rat and human VSMCs. After administration with agonists of the Wnt (SKL2001) and AKT (SC79), there appeared more osteoblastic differentiation and higher expression of Runx2 in gAd-treated VSMCs, but showing lower impact in the presence of SC79 than that in the presence of SKL2001. In the in vivo experiments, intravenous injection of gAd also significantly inhibited VC and Runx2 level in uraemic rat in a dose-dependent manner, possibly through regulating Wnt/β-catenin pathway. This study demonstrates that gAd ameliorates osteoblastic differentiation of VSMCs possibly by blocking PI3K/AKT and Wnt/β-catenin signaling transduction. The findings provide an important foundation for gAd in treating VC in kidney diseases.
Importance of anions in electrodeposition of nickel from gluconate solutions
Authors: Chat-Wilk Karolina , Rudnik Ewa , Włoch Grzegorz , Osuch Piotr 
Published: August 2021

AbstractElectrodeposition of nickel from slightly acidic gluconate solutions containing chloride or/and sulfate ions was investigated. Electrochemical measurements correlated with bath speciations showed nickel chloride complex and nickel sulfate complexes as crucial species affecting cathodic reactions in a potential range up to −1.3V. At more negative potentials, nickel deposition was governed by a release of nickel cation from nickel-gluconate complex. This was further evidenced by differences in nucleation modes, morphology, and structure of the deposits. Wettability of as-plated and chemically modified nickel layers were determined and correlated with their morphology and corrosion resistance.
Clinical Ethics Consultations in the Opinion of Polish Physicians
Authors: Czarkowski Marek , Różyńska Joanna , Maćkiewicz Bartosz , Zawiła-Niedźwiecki Jakub 
Published: August 2021

AbstractClinical Ethics Consultations (CEC) are an important tool for physicians in solving difficult cases. They are extremely common in North America and to a lesser extent also present in Europe. However, there is little data on this practice in Poland. We present results of a survey of 521 physicians practising in Poland concerning their opinion on CECs and related practices. We analysed the data looking at such issues as CECs’ perceived availability, use of CECs, and perceived usefulness of such support. Physicians in our study generally encounter hard ethics cases, even—surprisingly—those who do not work in hospitals. Most physicians have no CEC access, and those that do still do not employ CECs. However, physicians perceive this form of support as useful—even more so among actual users of CECs. We compared these findings with similar studies from other European countries and the North America. We point out peculiarities of our results as compared to those in other countries, with some possible explanations. We hope the results may encourage regulatory debate on the need to formally introduce CECs into the Polish healthcare system.
Attitudes and perceptions of outpatients towards adoption of telemedicine in healthcare during COVID-19 pandemic
Authors: Naik Nithesh , Ibrahim Sufyan , Sircar Sumedha , Patil Vathsala , Hameed Belthangady Monu Zeeshan , Rai Bhavan Prasad , Chłosta Piotr , Somani Bhaskar K. 
Published: August 2021

Abstract
Background
Asia is home to a burgeoning market for telemedicine with the availability of cheaper smartphones and internet services. Due to a rise in telemedicine use by doctors and patients, it is imperative to understand the perception of patients towards the adoption of telemedicine, the availability of telemedicine to the general population, the frequency with which patients avail these services, and the motivation or apprehensions in using them, especially during the COVID-19 pandemic.

Aims
The study is performed to understand the behavioral attitude and perceptions of the population regarding telemedicine and, in doing so, make services more user-friendly for patients.

Methods
A total of 1170 participants were surveyed using a structured online questionnaire to assess the perceptions towards the adoption of telemedicine in healthcare delivery services. Multivariate analysis was performed to identify key variables of knowledge and attitude affecting the utilization of telemedicine.

Results
Of the total respondents, 35.3% of patients never encountered telemedicine before and 26.9% did not come across telemedicine even during the COVID-19 pandemic.

Conclusion
Understanding the perceptions of patients, using targeted health education, positive communication, and behavioral modifications, is the key factor to be addressed to mitigate the apprehensions towards telemedicine and improve the utilization of the services.
The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
Authors: Ke Kevin , Pillai Krishna , Mekkawy Ahmed H. , Akhter Javed , Badar Samina , Valle Sarah J. , Morris David L. 
Published: August 2021

AbstractIntraperitoneal administration of BromAc (bromelain + acetylcysteine) is currently undergoing a phase 1 clinical trial for pseudomyxoma peritonei at our institution. This study reports on analysis of routine blood parameters before and after treatment for a series of 25 patients in this trial. Blood parameters assessed included full blood count, electrolytes, urea, and creatinine, liver function tests, coagulation studies, as well as inflammatory markers (CRP). Certain parameters such as CRP, and white cell count, were significantly elevated after treatment whilst serum albumin level was reduced indicating an inflammatory reaction. However, liver enzymes, coagulation studies, and other parameters were not affected. Therefore, there are no additional safety signals evident upon analysis of routine blood parameter testing.
Microhabitat Selection and Population Density of Nehalennia Speciosa Charpentier, 1840 (Odonata: Coenagrionidae) in a Peripheral Microrefugium
Authors: Orioli Valerio , Gentili Rodolfo , Bani Luciano , Aguzzi Stefano 
Published: August 2021

AbstractPeripheral populations of boreal tyrphophilic animals and plants often occupy relict Alpine peatlands, which act as microrefugia. Ecological conditions within local peatlands can lead to uncommon adaptations, highly valuable for the long-term conservation of species and habitats. The pigmy damselfly (Nehalennia speciosa) is an endangered Odonata distributed in Central and Eastern Europe with peripheral populations in the Alps. We investigated the microscale species-habitat association and the conservation status of one of these populations in a relict raised bog. We applied dynamic N-mixture models to assess population ecology and density, while disentangling predictors’ effect on ecological and observation process. We counted N. speciosa individuals in spring 2018 along with vegetation, water, soil and weather conditions during surveys. Final model resulted reliable according to performance measures. Spatial variation in N. speciosa abundance was driven by vegetation type, with a strong selection for flooded hollows where C. rostrata, R. alba and S. palustris vegetation occupy acidic and oligotrophic shallow pools. Population density showed a peak in the first decade of June and increased with accumulation of superficial water. Detection probability was generally low and decreased further when wind blew. The reduced ecological plasticity of the species imperil the species to habitat and climate changes, which will be particularly threatening for its peripheral Alpine populations in the near future, causing water imbalance and rapid vegetation turnover within the peatlands’ fragile microhabitat. The studied peat bog could thus be retained a key future microrefugium for the long-term conservation of tyrphopilous wildlife and habitats.
Case study of a water bioengineering construction site in Austria. Ecological aspects and application of an environmental life cycle assessment model
Authors: von der Thannen M. , Hoerbinger S. , Muellebner C. , Biber H. , Rauch H. P. 
Published: August 2021

AbstractRecently, applications of soil and water bioengineering constructions using living plants and supplementary materials have become increasingly popular. Besides technical effects, soil and water bioengineering has the advantage of additionally taking into consideration ecological values and the values of landscape aesthetics. When implementing soil and water bioengineering structures, suitable plants must be selected, and the structures must be given a dimension taking into account potential impact loads. A consideration of energy flows and the potential negative impact of construction in terms of energy and greenhouse gas balance has been neglected until now. The current study closes this gap of knowledge by introducing a method for detecting the possible negative effects of installing soil and water bioengineering measures. For this purpose, an environmental life cycle assessment model has been applied. The impact categories global warming potential and cumulative energy demand are used in this paper to describe the type of impacts which a bioengineering construction site causes. Additionally, the water bioengineering measure is contrasted with a conventional civil engineering structure. The results determine that the bioengineering alternative performs slightly better, in terms of energy demand and global warming potential, than the conventional measure. The most relevant factor is shown to be the impact of the running machines at the water bioengineering construction site. Finally, an integral ecological assessment model for applications of soil and water bioengineering structures should point out the potential negative effects caused during installation and, furthermore, integrate the assessment of potential positive effects due to the development of living plants in the use stage of the structures.
Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy
Authors: Yao Shuncheng , Liu Zhirong , Li Linlin 
Published: August 2021

AbstractCovalent organic frameworks (COFs) as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules. Their precise assembly, well-defined coordination network, and tunable porosity endow COFs with diverse characteristics such as low density, high crystallinity, porous structure, and large specific-surface area, as well as versatile functions and active sites that can be tuned at molecular and atomic level. These unique properties make them excellent candidate materials for biomedical applications, such as drug delivery, diagnostic imaging, and disease therapy. To realize these functions, the components, dimensions, and guest molecule loading into COFs have a great influence on their performance in various applications. In this review, we first introduce the influence of dimensions, building blocks, and synthetic conditions on the chemical stability, pore structure, and chemical interaction with guest molecules of COFs. Next, the applications of COFs in cancer diagnosis and therapy are summarized. Finally, some challenges for COFs in cancer therapy are noted and the problems to be solved in the future are proposed.