bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN PEMANFATAN PERAN TEKNOLOGI INFORMASI BAGI MASYARAKAT SEKITAR POLSEK PORSEA KAB.TOBA SAMOSIR
Authors: Almeina Lubis Iin , Aulia Romy , Madonna Yuma Febby 
Published: February 2021

Abstrack: Community Service Activities in the form of training on the use of the internet at Porsea Sub-District of Toba Samosir District aim to increase the knowledge of the surrounding community about internet technology and the benefits of the internet and encourage surrounding communities to be able to independently manage and utilize network and internet functions. The main target in this community service is the community around Porsea Sub-District, Toba Samosir District. The training method used is a form of training in the classroom using the lecture method, discussion and question and answer. The lecture method used is intended to provide a theoretical explanation of internet and network material. The discussion method is used to explore the understanding of the surrounding community about the material given in lectures. Practice methods are used to show how to use the internet properly and correctly. The benefits of this training activity are that the surrounding community is able to use the internet and the network for positive and useful things. Keywords: Internet, Benefits, Training, Networks Abstrak : Kegiatan Pengabdian Pada Masyarakat berupa pelatihan pemanfaatan internet di Polsek Porsea Kab.Toba Samosir bertujuan untuk meningkatkan pengetahuan masyarakat sekitar terhadap teknologi internet dan manfaat dari internet serta mendorong masyarakat sekitar agar mampu dengan mandiri mengelola dan memanfaatkan fungsi jaringan dan internet. Khalayak sasaran dalam pengabdian masyrakat ini adalah masyarakat sekitar Polsek Porsea Kab.Toba Samosir. Metode pelatihan yang digunakan adalah bentuk pelatihan di dalam kelas dengan menggunakan metode ceramah, diskusi dan tanya jawab. Metode ceramah yang digunakan dimaksudkan untuk memberikan penjelasan secara teori terhadap materi internet dan jaringan. Metode diskusi digunakan untuk menggali pemahaman masyarakat sekitar terhadap materi yang diberikan secara ceramah. Metode praktek digunakan untuk menunjukan langsung cara menggunakan internet yang baik dan benar. Manfaat yang diperoleh dari kegiatan pelatihan ini adalah masyarakat sekitar mampu menggunakan internet dan jaringan untuk hal-hal positif dan bermanfaat. Kata kunci : Internet, Manfaat, Pelatihan, Jaringan
Implementasi 360 Degree untuk Membantu Proses Pelaporan Kinerja Dosen (Studi Kasus; JTI Polinema)
Authors: Misbahudin  , Rudy Ariyanto  , Yoppy Yunhasnawa  
Published: February 2021

Untuk menuju tujuan pendidikan nasional tersebut diperlukan dosen yang professional. Evaluasi kinerja dosen diperlukan agar dalam melaksanakan tugas dan tanggung jawabnya sejalan dengan apa yang diisyaratkan dalam UU No. 14 Tahun 2005 tentang guru dan dosen, Dalam melaksanakan penilaian yang benar, maka penilaian dilakukan oleh pihak yang tepat yang dapat memberikan kontribusi penilaian yang baik. Hal ini cocok dengan metode 360 degree yang menilai seseorang dari pihak-pihak yang berada di sekitarnya. Penelitian ini menggunakan konsep sistem pendukung keputusan kelompok (GDSS) sebagai metode pengolahan data dengan 3 penilai yaitu atasan, mahasiswa, dan rekan sesama dosen. Sistem pendukung keputusan kelompok yang dikembangkan dalam penelitian ini menggunakan metode AHP (Analytical Hierarchy Process) dan Borda untuk penentuan keputusan kelompok. Metode AHP digunakan untuk penentuan bobot kriteria dari setiap alternatif. Metode Borda digunakan untuk penggabungan hasil perangkingan yang didapat oleh setiap pengambil keputusan sehingga mendapatkan perangkingan akhir dan mendapatkan skor setiap alternatif. Kriteria yang digunakan antara lain: Kepribadian, Pedagogik, Sosial, dan Profesional. Hasil dari pengujian dari 10 data uji, dapat disimpulkan tingkat akurasi yakni sebesar 20 %. Presentase yang rendah ini disebabkan penilaian kinerja yang selama ini diterapkan tidak menggabungkan penilaian dari mahasiswa, atasan dan rekan sejawat. Selain itu tidak ada penilaian untuk rekan kerja.
Ca2+ Complexation With Relevant Bioligands in Aqueous Solution: A Speciation Study With Implications for Biological Fluids
Authors: Aiello Donatella , Carnamucio Federica , Cordaro Massimiliano , Foti Claudia , Napoli Anna , Giuffrè Ottavia 
Published: February 2021

A speciation study on the interaction between Ca2+and ligands of biological interest in aqueous solution is reported. The ligands under study arel-cysteine (Cys),d-penicillamine (PSH), reduced glutathione (GSH), and oxidized glutathione (GSSG). From the elaboration of the potentiometric experimental data the most likely speciation patterns obtained are characterized by only protonated species with a 1:1 metal to ligand ratio. In detail, two species, CaLH2and CaLH, for systems containingCys,PSH, andGSH, and five species, CaLH5, CaLH4, CaLH3, CaLH2, and CaLH, for system containingGSSG, were observed. The potentiometric titrations were performed at different temperatures (15 ≤t/°C ≤ 37, atI= 0.15 mol L−1). The enthalpy and entropy change values were calculated for all systems, and the dependence of the formation constants of the complex species on the temperature was evaluated.1H NMR spectroscopy, MALDI mass spectrometry, and tandem mass spectrometry (MS/MS) investigations on Ca2+-ligand solutions were also employed, confirming the interactions and underlining characteristic complexing behaviors ofCys,PSH,GSH, andGSSGtoward Ca2+. The results of the analysis of1H NMR experimental data are in full agreement with potentiometric ones in terms of speciation models and stability constants of the species. MALDI mass spectrometry and tandem mass spectrometry (MS/MS) analyses confirm the formation of Ca2+-L complex species and elucidate the mechanism of interaction. On the basis of speciation models, simulations of species formation under conditions of some biological fluids were reported. The sequestering ability ofCys,PSH,GSH, andGSSGtoward Ca2+was evaluated under different conditions of pH and temperature and under physiological condition.
Paroxysms at Stromboli Volcano (Italy): Source, Genesis and Dynamics
Authors: Métrich Nicole , Bertagnini Antonella , Pistolesi Marco 
Published: February 2021

Deciphering the triggering mechanisms of violent explosive activity is of broad interest for understanding the dynamics of basaltic open-vent volcanic systems. For nearly 1300 years Stromboli has been renowned not only for its continuous degassing activity and mild explosions at the summit craters, but also for short-lived, violent explosive events of variable scale, known as major explosions and paroxysms. Here, we focus on the 1456 and 1930 paroxysms and on the most recent events, in July and August 2019 at Stromboli. We show that shallow phenomena such as flank collapse, lava outpouring through fractures opening, or partial emptying of the shallow conduit, only speed up volatile-rich magma ascent by increasing the decompression rate, whereas pressurization of the crustal system and the deep refilling by magma and its CO2-rich gas phase play a major role in triggering paroxysms. Moreover, we present new data on the geochemistry of the 2019 bulk pumice, along with a compilation of data from the literature, chemical profiles in olivine crystals, and the physical parameters of explosive eruptions of wide ranging magnitude and intensity. For small and large paroxysms, timescales were derived from Fe–Mg diffusion profiles in olivine. In both types of explosion, the last phases of crystallization-diffusion indicate rapid magma ascent rates of two to ten days prior to eruption. Trace element concentrations (Nb, La and Ba) and ratios (Rb/Th) indicate that the 2019 pumice samples plot in the domain of magma batches erupted within the last 20 years at Stromboli. As a whole, there is no correlation between magma geochemistry and magnitude or intensity of explosive eruptions, which span a range of ∼3 orders of magnitude (from major explosions to large paroxysms) based on estimates of erupted tephra volumes. In contrast, olivine compositions are a good proxy for erupted tephra volumes and magma flux. The correlation among physical and chemical parameters, which is valid for the overall spectrum of eruptions, implies that the magmatic source ultimately controls eruptive dynamics.
Within-Person Variation in Serum Thyrotropin Concentrations: Main Sources, Potential Underlying Biological Mechanisms, and Clinical Implications
Authors: van der Spoel Evie , Roelfsema Ferdinand , van Heemst Diana 
Published: February 2021

BackgroundIndividuals exhibit fluctuations in the concentration of serum thyroid-stimulating hormone (TSH) over time. The scale of these variations ranges from minutes to hours, and from months to years. The main factors contributing to the observed within-person fluctuations in serum TSH comprise pulsatile secretion, circadian rhythm, seasonality, and ageing. In clinical practice and clinical research however, such within-person biological variation in serum TSH concentrations is often not considered. The aim of this review is to present an overview of the main sources of within-person variation in TSH levels, as well as the potential underlying biological mechanisms, and the clinical implications.SummaryIn euthyroid individuals, the circadian rhythm, with a nocturnal surge around 02:00–04:00 h and a nadir during daytime has the greatest impact on variations in serum TSH concentrations. Another source of within-person variation in TSH levels is seasonality, with generally higher levels during the cold winter months. Since TSH is secreted in a pulsatile manner, TSH levels also fluctuate over minutes. Furthermore, elevated TSH levels have been observed with ageing. Other factors that affect TSH levels include thyroid peroxidase (TPO)-antibody positivity, BMI, obesity, smoking, critical illness, and many xenobiotics, including environmental pollutants and drugs. Potential underlying biological mechanisms of within-person variation in TSH levels can be safely concluded from the ability of TSH to respond quickly to changes in cues from the internal or external environment in order to maintain homeostasis. Such cues include the biological clock, environmental temperature, and length of day. The observed increase in TSH level with ageing can be explained at a population level and at an organism level. In clinical practice, the season for thyroid testing can influence a patient’s test result and it occurs frequently that subclinical hypothyroid patients normalize to euthyroid levels over time without intervention.ConclusionsSerum TSH concentrations vary over time within an individual, which is caused by multiple different internal and external factors. It is important to take the within-person variations in serum TSH concentrations into account when testing a patient in clinical practice, but also in performing clinical research.
Targeting miR-148b-5p Inhibits Immunity Microenvironment and Gastric Cancer Progression
Authors: Zhang Yuyu , Huo Wei , Sun Lidi , Wu Jie , Zhang Chengbin , Wang Huanhuan , Wang Bin , Wei Jinlong , Qu Chao , Cao Hongshi , Jiang Xin 
Published: February 2021

BackgroundMicroRNAs (miRNAs) have been discovered to dictate the development of various tumors. However, studies on the roles of miRNAs in the progression of gastric cancer (GC) are still lacking.MethodsHerein, by analyzing GC cell lines and patients samples, we observed that miR-148b-5p was significantly downregulated in GC. We also confirmed that miR-148b-5p overexpression significantly inhibited GC cell proliferation and invasion in vitro and in vivo.ResultsOverexpression of miR-148b-5p not only reprogrammed the metabolic properties of GC but also regulated the immune microenvironment by shifting lymphocyte and myeloid populations. Mechanistically, ATPIF1, an important glycolysis-associated gene, was identified as a direct target of miR-148b-5p and mediated the effect of miR-148b-5p. Notably, the low level of miR-148b-5p was significantly related with poor prognosis of GC patients (P &lt; 0.001). Importantly, the levels of miR-148b-5p significantly changed the sensitivity of GC cells to several anti-cancer drugs (Doxorubicin, P &lt; 0.05, Paclitaxel, P &lt; 0.01, Docetaxel, P &lt; 0.05).ConclusionsTargeting miR-148b-5p inhibits immunity microenvironment and gastric cancer progression.
Changes in the Peripheral Blood Treg Cell Proportion in Hepatocellular Carcinoma Patients After Transarterial Chemoembolization With Microparticles
Authors: Ren Zhizhong , Yue Yuanxun , Zhang Yuewei , Dong Jiahong , Liu Ying , Yang Xiaowei , Lin Xin , Zhao Xueqiang , Wei Zhanqi , Zheng Yu , Wang Tianxiao 
Published: February 2021

ObjectiveTransarterial chemoembolization (TACE) stands for an ideal therapy for patients with intermediate stage HCC. This study was carried out to observe the effect of microparticles-transarterial chemoembolization (microparticles-TACE, m-TACE) on the immune function of hepatocellular carcinoma (HCC) patients by detecting the proportion of regulatory (Treg) cells in the peripheral blood of HCC patients before and after m-TACE, and to determine whether m-TACE has a positive regulatory effect on the immune function of HCC patients.Methods33 HCC patients treated with Gelatn Sponge Microparticles (GSMs-TACE) were enrolled. Flow cytometry was used to determine the proportion of Treg cells and CD4+/CD8+ T cells in peripheral blood of HCC patients 1 day before GSMs-TACE, 1 to 2 weeks and 3 to 5 weeks after GSMs-TACE, respectively.ResultsThe Tregs cell proportion of HCC patients was significantly higher than that of the healthy and cirrhosis controls and was associated with various clinical indicators of HCC patients. The Treg cell proportion in HCC patients with BCLC stage C was higher than that of stage B patients; The Treg cell proportion at 1 to 2 weeks postoperatively was 8.54 ± 1.27%, which was significantly lower than that before the GSMs-TACE. The Treg cell proportion at 3 to 5 weeks postoperatively was 7.59 ± 1.27%, which continued to decline. The ratio of CD4+/CD8+ T cells was 1.31 ± 0.56, 1.86 ± 0.73, 1.76 ± 0.58% (P&lt;0.01) respectively.ConclusionThese results indicated that m-TACE could exert a positive regulatory effect on the anticancer immune function of HCC patients, which may be used in combination with immune adjuvant therapies to enhance the efficacy of HCC.
Unsupervised Clustering Reveals Sarcoidosis Phenotypes Marked by a Reduction in Lymphocytes Relate to Increased Inflammatory Activity on 18FDG-PET/CT
Authors: Vagts Christen , Ascoli Christian , Fraidenburg Dustin R. , Baughman Robert P. , Huang Yue , Edafetanure-Ibeh Russell , Ahmed Samreen , Levin Benjamin , Lu Yang , Perkins David L. , Finn Patricia W. , Sweiss Nadera J. 
Published: February 2021

Introduction: Sarcoidosis is a T-helper cell mediated disease characterized by granulomatous inflammation. We posited that unsupervised clustering of various features in sarcoidosis would establish phenotypes associated with inflammatory activity measured by 18FDG-PET/CT. Our goal was to identify unique features capable of distinguishing clusters and subsequently examine the relationship with FDG avidity to substantiate their potential use as markers for sarcoidosis inflammation.Methods: We performed a retrospective study of a diverse, but primarily African American, cohort of 58 subjects with biopsy proven sarcoidosis followed at the University of Illinois Bernie Mac Sarcoidosis Center and Center for Lung Health who underwent 18FDG-PET/CT scan. Demographic, therapeutic, radiographic, and laboratory data were utilized in unsupervised cluster analysis to identify sarcoidosis phenotypes. The association between clusters, their defining features, and quantitative measurements on 18FDG-PET/CT was determined. The relevance of these features as markers of 18FDG-PET/CT inflammatory activity was also investigated.Results: Clustering determined three distinct phenotypes: (1) a predominantly African American cluster with chronic, quiescent disease, (2) a predominantly African American cluster with elevated conventional inflammatory markers, advanced pulmonary disease and extrathoracic involvement, and (3) a predominantly Caucasian cluster characterized by reduced lymphocyte counts and acute disease. In contrast to the chronic quiescent cluster, Clusters 2 and 3 were defined by significantly greater FDG avidity on 18FDG-PET/CT. Despite similarly increased inflammatory activity on 18FDG-PET/CT, Clusters 2, and 3 differed with regards to extrathoracic FDG avidity and circulating lymphocyte profiles, specifically CD4+ T-cells. Notably, absolute lymphocyte counts and CD4+ T-cell counts were found to predict 18FDG-PET/CT inflammatory activity by receiver operating curve analysis with a 69.2 and 73.42% area under the curve, respectively.Conclusions: Utilizing cluster analysis, three distinct phenotypes of sarcoidosis were identified with significant variation in race, disease chronicity, and serologic markers of inflammation. These phenotypes displayed varying levels of circulating inflammatory cells. Additionally, reduction in lymphocytes, specifically CD4+ T-cells, was significantly related to activity on 18FDG-PET/CT. Though future studies are warranted, these findings suggest that peripheral lymphocyte counts may be considered a determinant of sarcoidosis phenotypes and an indicator of active inflammation on 18FDG-PET/CT.
Analysis of Circulating Microvesicles Levels and Effects of Associated Factors in Elderly Patients With Obstructive Sleep Apnea
Authors: Tan Jin , Xing Huifang , Sha Sha , Li Jinwen , Miao Yuyang , Zhang Qiang 
Published: February 2021

Background: The incidence of obstructive sleep apnea (OSA) in the elderly is high, and the disorder is associated with a variety of chronic diseases. Microvesicles (MVs) are extracellular vesicles secreted by various cells during stimulation or apoptosis that play an important role in the pathogenesis of OSA. However, concentrations of circulating MVs in elderly patients with OSA remain unclear.Methods: Patients aged &gt;60 years old were recruited and underwent polysomnography. Circulating plasma MV concentrations, including annexin V+MVs, endothelial MVs (EMVs), platelet MVs (PMVs), and leukocyte MVs (LMVs) levels, were measured using a flow cytometer with different labeling methods. Potential factors affecting the concentration of circulating MVs in elderly patients with OSA were determined via Spearman's correlation and multiple linear regression analysis.Results: Levels of circulating MVs, including both single- (annexin V+MVs, CD144+EMVs, CD41a+PMVs, and CD45+LMVs) and dual-labeled MVs (annexin V+CD144+EMVs), were elevated in elderly patients with OSA. Circulating MVs were positively correlated with OSA severity (AHI, ODI, and SPO2min). To some extent, obesity affected the MV concentrations in elderly patients with OSA. In addition, age and comorbidities may be associated with MV levels, but the correlations between the MV levels and age or comorbidities were not significant.Conclusion: Concentrations of circulating MVs in elderly patients with OSA are associated with the labeling method used, OSA severity, and obesity. The effects of age and comorbidities on circulating MV levels require further verification using a larger sample size.
Weight Change After Subthalamic Nucleus Deep Brain Stimulation in Patients With Isolated Dystonia
Authors: He Weibin , Li Hongxia , Lai Yijie , Wu Yunhao , Wu Yiwen , Ramirez-Zamora Adolfo , Yi Wei , Zhang Chencheng 
Published: February 2021

Purpose: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment method for advanced Parkinson's disease (PD) and isolated dystonia and provides marked improvement of major motor symptoms. In addition, non-motor effects have been reported including weight gain (WG) in patients with PD after STN-DBS. However, it is still unclear whether patients with isolated dystonia also experience WG.Methods: Data from 47 patients with isolated dystonia who underwent bilateral STN-DBS surgery between October 2012 and June 2019 were retrospectively collected. The severity of dystonia was assessed via the Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS). Changes in the body mass index (BMI) and BFMDRS score were analyzed using paired Student's t-tests. Regression analysis was performed to identify factors that affected the BMI after surgery.Results: Postoperative WG was observed in 78.7% of patients. The percentage of overweight and obese patients increased from 25.5% (before STN-DBS) to 48.9% (at the last follow-up). The mean BMI and mean percentage change in BMI increased by 1.32 ± 1.83 kg/m2 (P &lt; 0.001) and 6.28 ± 8.34%, respectively. BMI increased more in female than in male patients. At the last follow-up, BFMDRS movement and disability scores improved by 69.76 ± 33.23% and 65.66 ± 31.41%, respectively (both P &lt; 0.001). The final regression model analysis revealed that sex and preoperative BMI alone were independently associated with BMI change (P &lt; 0.05).Conclusions: STN-DBS is associated with postoperative WG with patients with isolated dystonia. WG is more prominent in female patients and is associated with preoperative weight but not with the efficacy of STN-DBS on motor symptoms.
TaSCA, an Agile Survey on Chemosensory Impairments for Self-Monitoring of COVID-19 Patients: A Pilot Study
Authors: Mucignat-Caretta Carla , Bisiacchi Patrizia , Marcazzan Gian Luigi , Calistri Arianna , Parolin Cristina , Antonini Angelo 
Published: February 2021

Background/Objective: During the COVID-19 pandemic, smell and taste disorders emerged as key non-respiratory symptoms. Due to widespread presence of the disease and to difficult objective testing of positive persons, the use of short surveys became mandatory. Most of the existing resources are focused on smell, very few on taste or trigeminal chemosensation called chemesthesis. However, it is possible that the three submodalities are affected differently by COVID-19.Methods: We prepared a short survey (TaSCA) that can be administered at the telephone or through online resources to explore chemosensation. It is composed of 11 items on olfaction, taste, and chemesthesis, in order to discriminate the three modalities. We avoided abstract terms, and the use of semiquantitative scales because older patients may be less engaged. Statistical handling included descriptive statistics, Pearson's chi-squared test and cluster analysis.Results: The survey was completed by 83 persons (60 females and 23 males), which reported diagnosis of COVID-19 by clinical (n = 7) or molecular (n = 18) means, the others being non-COVID subjects. Cluster analysis depicted the existence of two groups, one containing mostly asymptomatic and one mostly symptomatic subjects. All swab-positive persons fell within this second group. Only one item, related to trigeminal temperature perception, did not discriminate between the two groups.Conclusions: These preliminary results indicate that TaSCA may be used to easily track chemosensory symptoms related to COVID-19 in an agile way, giving a picture of three different chemosensory modalities.