bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYNTHESIS AND CHARACTERIZATION OF HPMC/HAp/Fe3O4 COMPOSITE FOR HYPERTHERMIA APPLICATION
Authors: Muflikhah Muflikhah , Lubis Wildan Zakiah , Ardiani Irma Septi , Nadiyyah Khoirotun , Sukaryo Sulistioso Giat 
Published: September 2021

SYNTHESIS AND CHARACTERIZATION OF HPMC/HAp/Fe3O4 COMPOSITE FOR HYPERTHERMIA APPLICATION. Magnetic material become subject of intense research for hyperthermia application, and injectable magnetic hyperthermia for bone cancer is one of this research interest. In this study, composite of hydroxyapatite (HAp) and Fe3O4 in Hydroxypropyl-methyl cellulose (HPMC) matrix (HPMC/HAp/Fe3O4) has been synthesized in gel form that are expected can be applied for injectable bone substitute (IBS) in hyperthermia therapy. Composites were made using conventional methods by mixing HAp powder with ferrofluid Fe3O4 in HPMC solution. The composition of the composites were varied with the mass comparison of HPMC: HAp: Fe3O4 was 1: 0: 0; 1: 3: 0; 1: 2: 0.5; 1: 1: 0.25; and 1: 0: 3. The physical, chemical, and magnetic properties of the composites were characterized using X-Ray Diffractometer (XRD), Fourier Transform Infrared Spectrometry (FT-IR), Particle Size Analyzer (PSA), and Vibrating Sample Magnetometer (VSM). The XRD characterization results of the HPMC/HAp/Fe3O4 composite showed the crystalline phase of the constituent components. Saturation magnetization of the HPMC/HAp/Fe3O4 composite was 2.72 emu/g and 1.79 emu/g for the composition of 1: 2: 0.5 and 1:1:0.25 respectively. HPMC/HAp/Fe3O4 composite has superparamagnetic and biocompatible properties, so that can be applied as IBS in hyperthermia therapy for bone cancer.
CHARACTERIZATION OF COMPOSITE CONTAINING LDPE (LOW DENSITY POLY ETHYLENE) AND MODIFIED PINEAPPLE LEAF FIBER
Authors: Wardani Lestari , Noerati Noerati , Sugiyana Doni 
Published: September 2021

CHARACTERIZATION OF COMPOSITE CONTAINING LDPE ( LOW DENSITY POLY ETHYLENE) AND MODIFIED PINEAPPLE LEAF FIBER. Pineapple leaf fiber could be used as a reinforcing material in natural fiber composites production with a synthetic polymer matrix. The typical problem in this process was the weak bond between the fiber component and the matrix. This study aimed to improve the bonds strength between pineapple leaf fibers and the polymer matrix of LDPE (Low Density Poly Ethylene) by modifying pineapple leaf fibers. The modification of pineapple leaf fibers was carried out through an enzymatic process using the xylanase enzyme. A modified fiber was then used as a fiber component in the composite using a commercial LDPE plastic matrix. Composites were made by the sandwich method using a hotpress machine at a temperature of 130 °C for 10 minutes. The evaluation of the composites were carried out by testing the tensile strength properties using the Tensolab tool and thermal properties using the TGA (Thermal Gravimetry Analysis) instrument. The results of the mechanical properties test of the composite showed the modified pineapple leaf fiber-based composite had a better tensile strength (34.3 MPa) than the untreated pineapple leaf fiber-based composite (30.2 MPa). The results of the thermal properties test showed the decreasing of the mass occurred at temperature of 300-350 °C due to degradation of the fiber,and it completely degraded at temperature of 450 °C.
Municipal Instruments in Law for Cultural Heritage Protection: A Case Study of the City of Cape Town Metropolitan Municipality
Authors: Steenkamp Rochine Melandri 
Published: September 2021

This article questions the extent to which municipal bylaws aimed at cultural heritage resource management (CHRM) reflect the objectives of the Constitution of the Republic of South Africa, 1996 (the Constitution), national legislation and the discourse on cultural governance more broadly. In terms of Schedule 4A of the Constitution, the function of "cultural matters" is not an original power of local government. It is a function assigned to the national and provincial spheres. Municipalities are assumed, however, to have a responsibility to execute aspects of this function that may be incidental to other typical local government functions. This view finds support in the interpretation of various rights in the Constitution (e.g. sections 15, 30, 31 and 24) as well as the heritage, environmental and local government framework legislation and policy documents of South Africa. The premise of this article is that cultural heritage resource management by way of instruments such as bylaws promotes the overarching objectives of local government, such as sustainable development, while also promoting the rights to culture, language and religion, amongst others. To expand on its theoretical basis, this article provides a critical assessment of the bylaws of the City of Cape Town Metropolitan Municipality
Determinants of Mudharabah Term Deposit: A Case of Indonesia Islamic Banks
Authors: Umam Fachru Nurul , Salam Annisa Nur , Rizal Achmad 
Published: September 2021

The growth of Islamic finance industries in Indonesia has shown significant improvement. The increased number of surplus units depositing their funds in Islamic banks has become a significant factor in their trust and confidence in Islamic banking products. One of the products utilized by the depositor is the mudharabah deposit product, where the Islamic bank offers higher profit compared to other types of deposit or saving. This paper aims to analyze the issues in a mudharabah term deposit in the Islamic banking industry in Indonesian Islamic banks. The issues concern more on the profit and risk in the mudharabah concept that has been applied in Islamic banks and the variables that affect the changes in mudharabah deposit product. We used the sample to analyze the issues by selecting 14 Islamic banks in Indonesia from 2011-2020. This research uses a quantitative approach with multiple linear regression analysis methods. Several variables are considered the independent variables to know the changes in the demand of mudharabah deposits in the Islamic bank, including interest rate, profit rate, number of office or branch units, and non-performing financing. Our analysis shows that the number of offices or branch units and non-performing financing positively impact the changes in demand of mudharabah deposits, while the interest rate and profit rate have a negative impact on mudharabah deposits.
Evaluación de grafeno y magnetita como membranas de intercambio de electrones en celdas de combustible microbianas con sustratos orgánicos para producir bioelectricidad
Authors: Guambo Galarza Alex 
Published: September 2021

En la actualidad los desafíos más importantes del desarrollo energético, es la incorporación de fuentes renovables de energía usando diversas tecnologías, de estos sistemas incluyen diferentes alternativas como es la generación de energía a partir de biomasa. Una forma de estos sistemas de biorreactores electroquímicos catalizados por microorganismos para la generación de formas energéticas usando biomasa como sustrato son las celdas de combustible microbianas (CCMs), que de acuerdo con sus características estructurales producen bioelectricidad conforme se degrada cierto requerimiento nutricional considerado como un contaminante potencial. Sin embargo, los bajos niveles de voltaje y densidad de potencia generados por una CCM limitan su aplicabilidad a gran escala. Esta investigación tiene como objetivo evaluar el grafeno y magnetita como membranas de intercambio de electrones para mejorar la estabilidad de voltaje y eficiencia en la generación de bioelectricidad, utilizando como inóculo suelo de páramo alto andino del Cantón Colta, mediante un sistema de tres conglomerados para obtener una muestra compuesta, de la cual fueron analizadas sus características físico-químicas. El sustrato empleado fue una mezcla 50:50 de frutas (naranja: Citrus sinensis, banano: Musa acuminata L. y manzana: Pyrus malus L.) y vegetales (arveja: Pisum sativum L., haba: Vicia faba L., zapallo: Cucurbita máxima Duchesne) en estado de descomposición; se analizó su contenido de Carbono, Nitrógeno, Hidrógeno y Azufre. La membrana de grafeno se obtuvo mediante exfoliación directa de óxido de grafito, previamente tratado en baño ultrasónico, sobre un tejido de fibra de carbono, mientras que la magnetita se sintetizó a partir de cloruro férrico y cloruro ferroso. El voltaje generado por las Celdas fue monitoreado durante quince días consecutivos, posteriormente se estimó la eficiencia de los materiales usados como membranas a través de una comparación de densidad de potencia y la degradación de su contenido. El voltaje promedio obtenido por celdas con grafeno fue 131mV, su densidad de potencia de 9,17mW/m2 y una degradación del sustrato de 8.60% (N), 35.29% (C), 24.49% (H) y 12,16% (S), mientras que celdas con magnetita consiguieron una degradación de 6.44% (N), 24.05% (C), 19.02% (H) y 11,35% (S) , un voltaje de 14mV y una densidad de potencia de 0,22 mW/m2 concluyendo que la membrana de grafeno tiene mayor rendimiento puesto que logró una densidad de potencia 42 veces mayor en relación a la magnetita.
O desenvolvimento nos territórios de fronteira: Análise dos indicadores socioeconômicos da região de planejamento Sul fronteira/MS
Authors: Miranda Belarmino Obedias , Marques Vieira Rosele 
Published: September 2021

Os indicadores socioeconômicos permitem mensurar e explicar a realidade vivida em uma região, conhecer e entende-los auxilia o poder público e a sociedade a pensar em ações e políticas públicas de investimento e transformação social. O objetivo deste estudo é analisar os indicadores socioeconômicos da Região Sul Fronteira, mensurados pelo PIB, renda per capita, emprego, IDHM, Coeficiente de Gini e IFDM. Para tanto foi desenvolvida uma pesquisa descritiva, elaborada a partir de dados secundários. Os resultados demonstram que a Região Sul Fronteira apresenta grandes disparidades econômicas e sociais, desenvolvimento humano médio de 0.634, alta concentração de renda, onde os 10% mais ricos se apropriam de mais de 44%. Fatos que favorecem a desigualdade e a baixa qualidade de vida de seus habitantes. Entretanto a região exibe um considerável potencial voltado para o agronegócio que oferece oportunidades claras para seu desenvolvimento socioeconômico.
Pengaruh Penambahan Tepung Jengkol (Archidendron pauciflorum) Terhadap Daya Terima Kerupuk Jengkol
Authors: Alsuhendra  , Persada Retno Agi , Ari Fadiati  
Published: September 2021

AbstractThis research aimed to portray the effect of jengkol flour addition with different concentrations on consumer acceptance. This research was conducted at the Food Processing Laboratory, Culinary Education, Faculty of Engineering, State University of Jakarta from February 2018 to January 2019. This research used an experimental method. The acceptance test was conducted by 30 semi-trained panelist including aspects of color, taste, aroma, crispness, linear expansion, and thickness. The results of hypothesis testing using the Friedman test with α = 0,05 showed that there is an effect of jengkol flour addition with different concentrations (30%, 50%, 70%) on consumers acceptance, color, taste, aroma, linear expansion and thickness aspects. While, there is no effect of jengkol flour addition in the manufacture of jengkol crackers on crispness aspect. In conclusion, Jengkol crackers with 50% of jengkol flour addition is recommended as the best formula.
Keywords: jengkol flour, jengkol crackers, consumer acceptance
AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh penambahan tepung jengkol dengan konsentrasi yang berbeda terhadap daya terima kerupuk jengkol. Penelitian di lakukan di Laboratorium Pengolahan Makanan, Program Studi Pendidikan Tata Boga, Fakultas Teknik, Universitas Negeri Jakarta sejak Februari 2018 hingga Januari 2020. Penelitian ini menggunakan metode eksperimen. Uji daya terima dilakukan kepada 30 orang panelis agak terlatih meliputi aspek warna, rasa, aroma, kerenyahan, daya kembang, dan ketebalan. Hasil pengujian hipotesis menggunakan uji Friedman dengan α = 0,05 menunjukkan bahwa terdapat pengaruh penambahan tepung jengkol dengan konsentrasi berbeda (30%, 50%, 70%) dalam pembuatan kerupuk jengkol terhadap daya terima kerupuk jengkol pada aspek warna, rasa, aroma, daya kembang, dan ketebalan, sedangkan pada aspek kerenyahan menunjukkan bahwa tidak terdapat pengaruh penambahan tepung jengkol terhadap daya terima kerupuk jengkol. Formula yang direkomendasikan adalah kerupuk jengkol dengan penambahan tepung jengkol 50%.
Kata-kata kunci: tepung jengkol, kerupuk jengkol, daya terima konsumen
ISLAMIC BANKING DEVELOPMENT AND FINANCIAL INCLUSION IN OIC MEMBER COUNTRIES: THE MODERATING ROLE OF INSTITUTIONS
Authors: Kamalu Kabiru , Wan Ibrahim Wan Hakimah Binti 
Published: September 2021

This study argues that the effect of Islamic banking development on financial inclusion is enhanced when there exist better quality institutions. A cross section dependency test, cointegration test, causality test, and system GMM (generalized method of moments) are applied to achieve this objective. Employing panel data from 30 Organisation of Islamic Cooperation (OIC) member countries over the period 2013-2018, the analysis suggests that Islamic banking promotes financial inclusion. Furthermore, it documents evidence which suggests negative and significant coefficients of the interaction between Islamic banking development and institutional quality. This means that Islamic banking development works well in promoting financial inclusion in countries with low institutional quality.
Experimental Study on the EOR Performance of Imbibition and Huff and Puff in Fractured Tight Oil Reservoirs
Authors: Zhang Zilin , Huang Bo , Zhang Liang , Zhou Guangqing , Liu Yanhui , Li Chenyang , Du Dianfa 
Published: September 2021

AbstractInjection of imbibition fluids or CO2 during hydraulic fracturing is an effective stimulation method for tight oil reservoirs. Selecting appropriate agents is significant to optimize the integrated scheme of fracturing and production in tight oil reservoirs. In this study, a series of lab experiments, including spontaneous imbibition, dynamic imbibition, and huff and puff, were carried out using real tight cores, water absorption apparatus, and core flooding equipment. The EOR performances of imbibition fluids and CO2 in fractured tight cores were compared. The mass transfer of imbibition fluids and CO2 in tight oil reservoirs and its influence on the sweeping volume and EOR mechanisms were discussed. The results show that (1) the spontaneous imbibition rate of imbibition fluids in tight cores is slow, and the oil recovery factor by spontaneous imbibition in cracked cores is relatively high, up to 13.42%. (2) In the dynamic imbibition experiments, the final oil recovery by CO2 injection was significantly higher than that by injecting imbibition liquids. Because of the excellent miscibility effect of CO2, oil production by CO2 injection mainly occurred in the primary displacement stage. Comparatively, the EOR effect of imbibition fluids mainly played its role during production after well shut-in, which can increase the oil recovery factor by 7.35%-11.64%. (3) The influence of the huff and puff mode of CO2 on EOR performance is greater than that of imbibition fluids due to its more sensitive compressibility and mass transfer rate. Generally, a high oil recovery factor can be obtained if the depletion production is conducted first, and a huff and puff operation is followed. (4) Comprehensively understanding the mass transfer characteristics of CO2 and imbibition fluids in tight oil reservoirs can guide the fracturing parameter design, such as the order of fracturing fluid slugs, the optimal soak time, and fracture spacing.
Identification of cathelicidin gene from Hoplobatrachus rugulosus and the antioxidant capacity of PC29 peptide
Authors: Tankrathok Anupong , Karnmongkol Chutima , Punpad Arpaporn , Wiriyaumpaiwong Piyachat , Srisam Nattapong , Rattanavichai Wutti , Tanomtong Alongkod , Daduang Sakda , Klaynongsruang Sompong 
Published: September 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
A User-Friendly Tool For Cloud-Based Whole Slide Image Segmentation, With Examples From Renal Histopathology
Authors: Lutnick Brendon , Manthey David , Becker Jan , Ginley Brandon , Moos Katharina , Zuckerman Jonathan , Rodrigues Luis , Gallan Alexander , Barisoni Laura , Alpers Charles , Wang Xiaoxin , Myakala Komuraiah , Jones Bryce , Levi Moshe , Kopp Jeffrey , Yoshida Teruhiko , Han Seung Seok , Jain Sanjay , Rosenberg Avi , Jen Kuang-Yu , Sarder Pinaki , Project Kidney Precision Medicine 
Published: September 2021

Abstract
We have developed Histo-Cloud, a tool for segmentation of whole slide images (WSIs) that has an easy-to-use graphical user interface. This tool runs a state-of-the-art convolutional neural network (CNN) for segmentation of WSIs in the cloud and allows the extraction of features from segmented regions for further analysis. By segmenting glomeruli, interstitial fibrosis and tubular atrophy, and vascular structures from renal and non-renal WSIs, we demonstrate the scalability, best practices for transfer learning, and effects of dataset variability. Finally, we demonstrate an application for animal model research, analyzing glomerular features in murine models of aging, diabetic nephropathy, and HIV associated nephropathy. The ability to access this tool over the internet will facilitate widespread use by computational non-experts. Histo-Cloud is open source and adaptable for segmentation of any histological structure regardless of stain.
Study of Coliforms And Clostridium Bacteria Inactivation In Wastewaters By A Pilot Photolysis Process And By The Maturation Lagoons of A Low-Cost Nature-Based WWTP
Authors: García-Prieto Juan Carlos , Núñez-Núñez Cynthia Manuela , Proal-Nájera José Bernardo , Garcia-Roig Manuel 
Published: September 2021

Abstract
The inactivation processes of coliform bacteria (total and fecal) and sulphito-reducing Clostridium bacteria (vegetative species and spores) in water maturation lagoon of a low-cost Nature-based wastewater treatment plant using constructed wetlands and through processes of photolysis in a pilot photoreactor have been comparatively studied. The different inactivation mechanisms by photolysis of these bacteria have been studied following the criteria of different statistical and kinetic models. Clostridium disinfection treatments fit models in which two types of bacteria populations coexist, one sensitive (vegetative species) and the other (spores) resistant to the treatment, the sensitive one (94 %) with an inactivation rate of k = 0.24 ± 0.07 min-1 and the resistant one (6 %) with k = 0.11 ± 0.05 min-1. Total coliform photolytic disinfection also shows two populations with different physiological state. The time required to reduce the first logarithmic decimal cycle of the different types of bacteria (physiological states) are δ1 = 4.2 ± 0.9 and δ2 = 8.3 ± 1.1 minutes respectively. For fecal coliform photolytic disinfection only bacteria population, with k = 1.15 ± 0.19 min-1, is found. The results obtained confirm the photolytic disinfection processes and maturation lagoon are effective systems for Clostridia bacteria removal after water treatment by nature-based systems. Total removal of coliform bacteria is not achieved by maturation lagoons but their reduction is significant using low doses of cumulative radiation.
When Choosing the Best Subset Is Not the Best Choice
Authors: Hanke Moritz , Dijkstra Louis , Foraita Ronja , Didelez Vanessa 
Published: September 2021

Abstract
Background: Variable selection in linear regression settings is a much discussed problem. Best subset selection (BSS) is often considered as an intuitively appealing ‘gold standard’, with its use being restricted mainly by its N P-hard nature. Instead, alternatives such as the least absolute shrinkage and selection operator (Lasso) or the elastic net (Enet) have become methods of choice in high-dimensional settings. A recent proposal represents BSS as a mixed integer optimization problem so that much larger problems have become feasible in reasonable computation time. This has been exploited to study the prediction performance of BSS and its competitors. Here, we present an extensive simulation study assessing, instead, the variable selection performance of BSS compared to forward stepwise selection (FSS), Lasso and Enet. The analysis considers a wide range of settings that are challenging with regard to dimensionality, signal-to-noise ratio and correlations between relevant and irrelevant direct predictors. As measure of performance we used the best possible F1 score for each method so as to ensure a fair comparison irrespective of any criterion for choosing the tuning parameters.Results: Somewhat surprisingly, it was only in settings where the signal-to-noise ratio was high and the variables were (nearly) uncorrelated that BSS reliably outperformed the other methods. This was the case even in low dimensional settings where the number of observations exceeded the number of variables by a factor of ten. Further, the FSS approach performed nearly identically to BSS. Conclusion: Our results shed a new light on the usual presumption of BSS being, in principle, the best choice for variable selection. More attention needs to be payed to the data generating process when considering variable selection methods. Especially for correlated variables, convex alternatives like Enet are not only faster but also appear to be more accurate in practical settings.
Modeling Cancer Immunoediting in Tumor Microenvironment with System Characterization through the Ising-model Hamiltonian
Authors: Rojas-Domínguez Alfonso , Arroyo-Duarte Renato , Rincón-Vieyra Fernando , Alvarado Matías 
Published: September 2021

Abstract
Background and Objective: Cancer Immunoediting (CI) describes the cellular-level interaction between tumor cells and the Immune System (IS) that takes place in the Tumor Micro-Environment (TME). CI is a highly dynamic and complex process comprising three distinct phases (Elimination, Equilibrium and Escape) wherein the IS can both protect against cancer development as well as, over time, promote the appearance of tumors with reduced immunogenicity. We present an agent-based model for the biological system in the TME, intended to simulate CI. Methods: Our model includes agents for tumor cells and for elements of the IS. The actions of these agents are governed by probabilistic rules, and agent recruitment (including cancer growth) is modeled via logistic functions. The system is formalized as an analogue of the Ising model from statistical mechanics to facilitate its analysis. The model was implemented in the Netlogo modeling environment and simulations were performed to verify, illustrate and characterize its operation. Results: Our model is capable of generating the three phases of CI; it requires only a couple of control parameters and is robust to these. We demonstrate how our simulated system can be characterized through the Ising-model energy function, or Hamiltonian, which captures the “energy” involved in the interaction between agents and presents it in clear and distinct patterns for the different phases of CI. Conclusions: The presented model is very flexible and robust, captures well the behaviors of the target system and can be easily extended to incorporate more variables such as those pertaining to different anti-cancer therapies. System characterization via the Ising-model Hamiltonian is a novel and powerful tool for a better understanding of CI and the development of more effective treatments.