bluuebunny/crossref_metadata_2025_split huggingface dataset:
7. Density of Lumbal Vertebrae Bone Ovariectomized Rat (Rattus Norvegicus) Given the Extract Sipatah – patah ( Cissus quadrangularis Salisb )
Authors: Dewi Putri , Sabri Mustafa , Rahmi Erdiansyah , Jalaluddin M , Asmilia Nuzul , Azhar Al 
Published: September 2021

The aims of this research was to determine the density level of lumbal vertebrae on ovariectomized rats administered with Cissus qudrangula Salisb stem extract with various doses. In this research twelve female rats were randomizedly divided into 4 groups with 3 treatment repetition. K1-groups were ovariectomized rats without Cissus quadrangula Salisb trunct extract administration; K2, K3, and K4, were ovariectomized and given with Cissus quadrangula Salisb extract with 500 mg/kg/Bw, 700 mg/kg/Bw, and 900 mg/kg/Bw as doses perday for 30 days. On day-31, rats were euthanized using chloroform and the os lumbal-5 were collected, followed with histological preparations. Research parameters were the density of active osteoblasts, passive osteoblasts, and osteoclasts. The results showed that the damage in K1 was clearly marked with the high number of osteoclasts, K2 and K3 indicate lower osteoclasts levels than K1 and had repaired bone structure characterized with active cuboidal shaped osteoblast activity and passive flat shaped osteoblasts and K4 showed increasing level of active osteoblasts. The administration of Cissus quadrangula Salisb stem extract at 900 mg/kg/bw for 30 days showed bone repair due to ovariectomy indicated with high level of active osteoblasts.
19. Identification of Ectoparasites in the Mud Crab (Scylla serrata) from Alue Naga Coastal Waters Banda Aceh
Authors: Maldini Audi , Winaruddin Winaruddin , Bakri Muttaqien , Hambal Muhammad , Farida Farida , Daud Razali 
Published: September 2021

This study aimsed to determine the type of ectoparasites on crab (Scylla serrata) in the water of Alue Naga Banda Aceh. The samples of this study were 10 heads of mud crabs were taken from the Alue Naga waters Banda Aceh and taken to the Laboratory of Parasitology. Veterinary Medicine Faculty of Syiah Kuala University Banda Aceh to identify the take ectoparasites on mud crab (Scylla serrata) by observing the outer body of the organism, then noted bleeding, wounds or swelling and pay attention to the type of organism that is attached to the body of mud crab, then dredge the outer parts of the body like the carapace, foot path, foot pool and gills were take it and then tweezers and then putting the object glass that has been provided and observed with a microscope with 100 times magnification and see what kind of ectoparasites that have been found and then compare with the identification key. From the results of this study concluded that ectoparasites which infects mud crab (Scylla serrata) in the waters of Alue Naga Banda Aceh come from genus Chilodonella sp. Whichare predilections in the gills with a prevalence rate of 10%.
6. The Effect of Celery Leaves Infusa (Apium graveolens L) on Reducing Level of Blood Glucose on Rat (Rattus norvegicus) Induced by Alloxan
Authors: Syarifahnur Fatin , Roslizawaty Roslizawaty , Amiruddin Amiruddin , Hasan Muhammad , Karmil T. Fadrial , Budiman Hamdani 
Published: September 2021

This study aims to investigate the effect of celery leaf infusa on decreasing level of blood glucose in rat (Rattus norvegicus). Twenty five rats were divided into 5 groups namely first treatment group (P1) as negative control. Second treatment group (P2) as positive control, rats were induced with alloxan. Third treatment group (P3) rats were induced with alloxan and given 5% celery leaf infusa. Fourth treatment group (P4) rats were induced with alloxan and given 10% celery leaf infusa. Fifth treatment group (P5) rats were induced alloxan and given 15% celery leaf infusa for 14 days. The level of blood glucose of the rat was determined before treatment, after given aloksan and after given celery leaf infusa. Data were analyzed using Analysis of Varians (ANOVA). Results showed that administration of celery leaf infusa for 14 days, show significant effect to decreasing level of glucose in rat (P0.01). It can be concluded that the administration of celery leaf infusa concentrated 5%, 10% and 15% for 14 days show significant effect to decreased level of glucose in rats.
17. Effect of Fermented Moringa leaf (Moringa oleifera) powder in Feed To Increase Broiler Carcass Weight
Authors: Manihuruk Feri Hardiansah , Ismail Ismail , Rastina Rastina , Razali Razali , Sabri Mustafa , Zuhrawati Zuhrawati , Jalaluddin Muhammad 
Published: September 2021

This study aimed to determine the effect of fermented kelor leaves (Moringa oleifera) flour as additive in animal feed to increase the weight of boiler carcass. The samples used were 28 DOC strain Cobb CP-707 aged 1 day. This study was conducted using one way pattern complete randomized design with 4 treatments and 7 replications. Control group (P0) was fed with commercial feed; P1 was given 5% fermented kelor leaves flour; P2 was given 7,5% fermented kelor leaves flour; and P3 was given 10% concentration of fermented kelor leaves flour. Feed replacement was conducted on 08.00 am and 5.00 pm everyday, and water was given ad libitum. Chemical content of flour before and after fermented was analyzed at Research Centre of Biotechnology and Biological Resources, IPB. Body weight measurement was carried out at Veterinary Public Health Laboratorium. Data were analyzed using ANOVA with SPSS 16.0. Mean value (±SD) of carcass weight for P0, P1, P2, and P3 were 938,71±180,83, 1011,86±101,64, 1010,71±126,69, and 907,43±190,35, respectively. This study showed that adddition of fermented kelor leaves flour for 21 days did not affect (P0,05) the weight of broilers carcass.
1. The Effect Of Moringa (Moringa olifera) Leaves Infusion On Hemoglobin Level Of Broiler Chicken (gallus-gallus domesticus)
Authors: NA Zuhrawati , Amiruddin Amiruddin , Mardian Yopi , Zuraidawati Zuraidawati , Asmilia Nuzul , Rusli Rusli , Lubis Triva Murtina 
Published: September 2021

The research aimed to determine the effect of Moringa leaves infuse toward the haemoglobin levels of broiler chickens. This study used 21 broiler chickens which divided into three groups and each group consisting of 7 broiler chickens. The treatment group (P0) were given only mineral water (aquadest), the treatment group (P1) were given moringa leaves infuse with a concentration of 10 % and treatment group (P2) infusion were given moringa leaves with a concentration of 20 %. The given of Moringa leaves infuse was starting at seven days old of chickens and given for 28 days continously as a drinking water. The chickens were feed by ad libitum during the research. After the treatment completion, a researcher carried out a blood sampling via the axillary vein. Data were analyzed with ANOVA by Complete Random Design one way and Tukey test to determine a difference between the treatments of each group. The research results showed that ± SD haemoglobin (g / dl) in the group (P0) 7.71 ± 1.13, (P1) of 8.15 ± 1.95 and (P2) 10.8 ± 1.76. Statistical analysis showed the treatment effect (P 0.05) of the haemoglobin levels of broiler chickens. The Tukey test results of the treatment group (P0) were significantly different (P 0.05) with treatment group (P2), but not significantly different (P 0.05) with treatment group (P1). The treatment group (P2) were significantly different (P 0.05) with treatment group (P1). From the results of this research, it was concluded that infuse Moringa leaves can improve haemoglobin levels of broiler chicken.
37. Risk Factors for Granulomatous Pneumonia Incidence in Lampung Breeding Farm
Authors: Susilo Joko , Saswinyanti Enny , Karmil Teuku Fadrial 
Published: September 2021

Complex respiratory disease in the calf (enzootic calves pneumonia) is a complex respiratory disease (bovine respiratory disease complex/BRDC) caused by co-infection with viral, bacterial or fungal pathogens. Granulomatous pneumonia is one of the dominant lesions in BRDC that characterizes the infection of Mycoplasma bovis, a bacterium that is very strong against phagocytosis of immun cells. This study aims to determine the presence of risk factors associated with the incidence of granulomatous pneumonia. This study used secondary data from Laboratory of Pathology in Balai Veteriner Lampung, Sample collection in 2015-2017 period from one of the breeding farm in Lampung. Data is processed by calculating frequency, tables and logistic regression in Epi-info tools. The frequency of granulomatous pneumonia at the age of pre weaning and weaning was 63.06% and 36.94%, breed Wagyu and Brahman cross (76.12% and 23.88%), as well as males and females (61.01% and 38.99%). The results of measurements with Epi-info show that the age factor (Odds ratio = 2.16, 95% CI = 1.51-3.09) and breeds (Odds ratio = 1.52, 95% CI = 1.003-2.31) were associated with the incidence of granulomatous pneumonia. Based on the results of research that Wagyu calf and weaning age are more at risk of granulomatous pneumonia.
The Investigation of Proppant Particle-Fluid Flow in the Vertical Fracture with a Contracted Aperture
Authors: Qu Hai , Wang Rui , Ao Xiang , Xue Ling , Liu Zhonghua , Lin Hun 
Published: September 2021

Summary
Proppant placement plays a crucial role in maintaining the conductivity of fractures after a hydraulic fracturing treatment. The process involves the transport of particles by fluid flow in complex fractures. Many studies have focused on proppant transport and distribution in the fracture with a constant aperture, but relatively few studies have investigated the proppant-fluid flow in a vertical fracture with a contracted aperture. In this work, we examine experimentally proppant transport in a fracture with a contracted aperture. The objective is to evaluate the distribution of particle beds in the contracted fracture at different flow conditions.
In this paper, particle-fluid flow in the contracted fracture is studied experimentally by a laboratory size slot. A planar slot with a constant width is used to benchmark the experimental results, and a published correlation validates the bed equilibrium heights in the planar slot. Six types of particles are chosen to simulate the effects of particle density and size. The proppant distribution is evaluated by the bed height when the bed reaches the equilibrium states. The effects of fluid velocity, fluid viscosity, particle density, particle size, and particle volume fraction on particle distribution are investigated.
The results confirm that the proppant particle-fluid flow in the contracted slot is more complicated than that in the planar slot. The phenomena of particle vortices and resuspension were observed at the contraction of the cross-section. The shape on the top of the bed is like a descending stair in which the height gradually decreases in the length direction. The bed height in the contracted slot is lower and more irregular than that in the planar slot at the same flow conditions. Smaller sands injected at a high flow rate and fluid viscosity can form a lower bed. The trend would be reversed by using denser particles and high particle volume fraction. A reliable model expressed by four dimensionless numbers is developed by the linear regression method for predicting the bed equilibrium height. The model and experimental results provide directions to quantitatively evaluate the particle transport and distribution in a fracture with a contracted aperture.
The ERA5’s Diurnal Cycle of Low-Level Clouds Over Western Central Africa During June-September: Dynamic and Thermodynamic Processes.
Authors: Dommo Atanas , Vondou Derbetini A. , Philippon Nathalie , Eastman Ryan , Moron Vincent , Aloysius Noel 
Published: September 2021

Abstract
This paper analyzes the diurnal cycle of low cloud cover (LCC) and the atmospheric conditions under which it grows over Western Central Africa during the cloudiest season (June-September). Moderate Resolution Imaging Spectroradiometer (MODIS) observations, Extended Edited Clouds Reports Archive (EECRA) and the fifth generation of reanalysis of the European Centre for Medium Range Weather Forecasts (ECMWF), i.e., ERA5 are used. LCC peaks between 04LT and 07LT and tends to be less dense during the afternoon. The associated dynamic and thermodynamic ERA5 conditions reveal different processes. The strong low level (below 1000 m) southwesterly flow in the evening supplies the region with humidity from the ocean and leads to cloud formation. Relative humidity (RH) tendencies show that temperature contributes to 100% of RH changes : the strong cooling observed after sunset at 19LT increases RH in the area of about 8%/h in the lower layer (below 1000m). The nighttime cooling shows strong cooling rates of about -1.4K/h after sunset till 22 LT, then rates decrease during the night to reach a value of about -0.3K/h between 22LT and 07LT. The cloud formation is mostly related to horizontal air advection, strong convergence in the lower layer and turbulent upwards mixing of moisture, while cooling at the cloud-top helps to maintain the cloud deck once it has formed. During daytime, solar radiation suppressed cooling at the cloud-top, thereafter strong turbulent kinetic energy acts to partly destroy the cloud deck and cloud fraction.
Symptom Management for Patients with Advanced Gastrointestinal Cancer Undergoing Chemotherapy Based on Patient-Reported Outcomes Obtained from Electronic Platforms
Authors: Dong Xuyuan , Wu Huili , Fan Yangwei , Zhang Miaomiao , Chen Xiaofang , Wu Yinying 
Published: September 2021

Abstract
Purpose: The electronic patient-reported outcome (ePRO) system plays an important role in routine cancer treatment, but information on its use to assess and monitor symptoms and quality of life (QoL) in advanced gastrointestinal cancer patients in China is limited.Methods: Sixty patients with advanced gastrointestinal cancer at the First Affiliated Hospital of Xi'an Jiaotong University were enrolled. They completed the ePRO questionnaires on a computer to provide nutrition, appetite, psychology, and QoL data at the beginning of cancer treatment. The nurses followed up the assessment results and provided feed-back to the clinicians, then, doctors addressed the symptoms according to the assessment results. The primary outcome was change in nutritional status. Secondary endpoints included appetite, psychological status and QoL.Results: There were 60 patients, 54 completed the follow-up. At the fourth visit, the Nutrition Risk Screening 2002 (NRS2002) and Patient-Generated Subjective Global Assessment (PG-SGA) scale scores improved significantly (p < 0.05). More than 70% of PG-SGA (73.08%), Functional Assessment of Anorexia/Cachexia Therapy Anorexia/Cachexia Subscale (FAACT-A/CS) (76.92%), Psychological Distress Thermometer (DT) (75.00%) and EuroQol Five Dimensions Questionnaire (EQ-5D) (78.84%) scores improved or remained stable. The results of the Generalized Linear Model (GLM) analysis showed that nutritional status, psychological status and QoL gradually improved with symptom management (p < 0.05).Conclusion: This symptom management closed-loop model can effectively manage the relevant symptoms of patients and improve QoL.Clinical trial information ChiCTR2100048290, date of registration July 5, 2021.
Burden of Care and Its Relationship with Sleep Quality of Cancer Patients’ Caregivers
Authors: Boostaneh Mohammadreza , Zirak Mohammad , Fallah Ramezan 
Published: September 2021

Abstract
Purpose: This study aimed to assess the burden of care and its relationship with sleep quality of cancer patients’ caregivers.Methods: This descriptive-correlational study was conducted in a referral center of cancer in Zanjan, northwest of Iran. 135 caregivers of cancer patients were recruited through convenience sampling method. The data were collected using a demographic characteristics questionnaire, Novak and Guest’s caregiver burden inventory and Pittsburgh sleep quality index (PSQI). The collected data was analyzed using descriptive and inferential statistics.Results: The mean (± SD) age of the participants was 39.71 (± 10.74) years. The mean (± SD) burden of care and sleep quality of the participants was 45.22 (± 17.75) and 8.88 (± 4.21), respectively. It was found that there is a significant positive relationship between burden of care and quality of sleep scores (r = 0.65, P < 0.001).Conclusion: cancer patients’ caregivers endure a remarkable burden of care and their sleep quality is undesirable. Results indicated that an increase in the burden of care reduces the caregiver’s quality of sleep. High burden of care and poor sleep quality may reduce the quality of the provided care that increase the costs and weakens the disease prognosis. According to the study results, reducing burden of care is an effective strategy regarding improving the caregivers’ quality of sleep that can improve the quality of provided cares by caregivers.
Status of the Quality-of-Life Index and its Related Factors in the Women of Rasht: A Population-Based Study
Authors: Namazi Asiyeh , Rafiey Hassan , Mousavi Mirtaher , Forouzan Ameneh Setareh , Harouni Gholamreza Ghaedamini 
Published: September 2021

Abstract
Background: Quality of Life is a key element in social policy so that its placement on the agenda of community development has a constructive and positive effect on the life and performance of the individual and society. This study was designed to assess the status of a quality-of-life index and some related factors in the public population of women in Rasht, which is the capital city of Guilan Province, Iran. Methods: This cross-sectional study was performed on 800 women in Rasht who were selected by cluster random sampling. The data collection tool was the Ferrans and Powers Quality of Life questionnaire, which has two parts: Satisfaction and Importance with life. Each section consists of four subscales: Health and performance, Social and economic, Psychological/spiritual, and Family. Its scoring is done on the Likert scale. Data analysis was done using descriptive statistics and one-way analysis of variance, independent t-test and regression. Results: The mean score (SD) of the quality-of-life index in this study was 21.39(4.10), which was higher than the mean level and showed a relatively good condition. There was a statistically significant difference between the mean score of the quality-of-life index in terms of education level, but within age groups, this difference was not significant. Correlation tests showed no statistically significant relationship between duration of the marriage, age of marriage and age of spouse with the women’s quality-of-life score of (p> 0.05). Conclusions: Although the quality of life of the women studied was above average, appropriate interventions should be designed to maintain and improve it, because the feeling of satisfaction increases the ability to cope with problems and mental pressures and improves the level of mental and physical health of couples and ultimately of all members of society.
Increased Numbers of Circulating Th22 and Th17 Cells in Patients with Kawasaki Disease
Authors: Liwen Zhang , Zhiying Huang , Mei Xue , Xiaoyu Zhang , Fei Wang , Xuan Zhao , Yu Wan , Liang Ma 
Published: September 2021

Abstract
Background

T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of Kawasaki Disease (KD).
Methods

A total of 43 patients with freshly diagnosed KD and 20 age-/gender-matched healthy controls (HC) were examined for the numbers of Th22, Th17 and Th1 cells were quantified by flow cytometry. The concentrations of serum IL-22, IL-17, IFN-γ and TNF-α were examined by enzymelinked immunosorbent assay.
Results

In comparison with those in the HC, significantly increased numbers of Th22 and Th17 cells, but not Th1 cells, and increased levels of serum IL-22 and IL-17, but not IFN-γ, were detected in KD patients. Stratification analysis indicated the numbers of both Th22 and Th17 cells and the concentrations of serum IL-22 and IL-17 in KD patients with coronary artery lesions (CAL) were significantly greater than that in those with noncoronary artery lesions (NCAL). Treatment with the intravenous immunoglobulin (IVIG) therapy significantly decreased numbers of Th22 and Th17 cells and concentrations of serum IL-22 and IL-17 in KD patients. The concentrations of serum IL-22 and IL-17 were correlated positively with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values as well as N-terminal pro-brain natriuretic peptide (NT-proBNP) in those patients respectively.
Conclusions

Our study provided direct evidence that Th22 and Th17 cells might contribute to the pathogenesis of KD.
β2 Integrin Antagonism, A Potential Mechanism To Sensitize CML Cells To Therapy As Revealed From Genetic Response To Radiation And LiCl
Authors: Verma Yogesh Kumar , Yadav Namrata , Kumar Subodh , Gurudutta Gangenahalli Ugraiah 
Published: September 2021

Abstract
Background: The interaction of integrins and growth factor receptors in cells is tightly regulated, ensuring cell survival, proliferation, differentiation, adhesion, and migration. The IR generates reactive oxygen species, which leads to ECM remodeling and cell adhesion through the activation of proteases, soluble cytokines and growth factors. Integrins and adhesion of cells to ECM confer higher resistance to ionizing radiation and cytotoxic drug, a phenomenon known as cell adhesion mediated radiation resistance (CAM-RR) and cell adhesion mediated drug resistance (CAM-DR).Integrins’ involvement in CML progression is well appreciated through its survival, adhesion and migration signaling. The evaluation of global genetic response (in microarray) of ionizing radiation (IR) on integrins expression has not been attempted to specify theirrole and other cell adhesion molecules (CAMs) in CML. In this study, we have compared the microarray based CAMs response in myelogenous leukemia cells onIR exposure. Results: Results revealed differential regulation of many CAMs, with strongest expression of integrin β2 (CD18), whose role has not been fully appreciated in CML due to low level of expression. However, the synergistic LiCl(GSK3β inhibitor) and IR treatment significantly upregulates CD18 expression leading to enhanced survival, cell adhesion mediated drug/radiation resistance (CAM-DR/RR) and transcription of migration related genes. These effects could be undermined in the presence of CD18 antibody. This may be one of the reasons for CML resistance to radiation therapy and its relapse upon stem cell transplantation.Conclusion: This study proposes CD18 antagonist administration as an adjuvant in anti-CML therapy and other cancers in which it displays aberrant expression subsuming the contraindication of GSK3β inhibitor. Nevertheless, the CD18 mediated cell adhesion in tumor progression beckons development of improved drug regimensandidentification of diagnostic and prognostic signature for CML.