bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust and Repeatable Biofabrication of Bacteria-Mediated Drug Delivery Systems: Effect of Conjugation Chemistry, Assembly Process Parameters, and Nanoparticle Size
Authors: Zhan Ying , Fergusson Austin , McNally Lacey R. , Davis Richey M. , Behkam Bahareh 
Published: October 2021

Bacteria-mediated drug delivery systems comprising nanotherapeutics
conjugated onto bacteria synergistically augment the efficacy of both
therapeutic modalities in cancer therapy. Nanocarriers preserve
therapeutics’ bioavailability and reduce systemic toxicity, while
bacteria selectively colonize the cancerous tissue, impart intrinsic and
immune-mediated antitumor effects, and propel nanotherapeutics
interstitially. The optimal bacteria-nanoparticle (NP) conjugates would
carry the maximal NP load with minimal motility speed hindrance for
effective interstitial distribution. Furthermore, a well-defined and
repeatable NP attachment density distribution is crucial to determining
these biohybrid systems’ efficacious dosage and robust performance.
Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery
System (NanoBEADS) platform to investigate the effects of assembly
process parameters of mixing method, volume, and duration on NP
attachment density and repeatability. We also evaluated the effect of
linkage chemistry and NP size on NP attachment density, viability,
growth rate, and motility of NanoBEADS. We show that the linkage
chemistry impacts NP attachment density while the self-assembly process
parameters affect the repeatability and, to a lesser extent, attachment
density. Lastly, the attachment density affects NanoBEADS’ growth rate
and motility in an NP size-dependent manner. These findings will
contribute to the development of scalable and repeatable
bacteria-nanoparticle biohybrids for applications in drug delivery and
beyond.

Corresponding author(s) Email:
behkam@vt.edu
Autoeficácia, habilidades sociais e clima escolar de estudantes do ensino fundamental
Authors: Falcão Amanda Oliveira , Leme Vanessa Barbosa Romera , Morais Gisele Aparecida de 
Published: October 2021

O estudo comparou a autoeficácia acadêmica, as habilidades sociais e o clima escolar de estudantes do final do Ensino Fundamental, considerando diferenças por sexo e a influência do histórico de reprovação escolar, a partir da Teoria Social Cognitiva. Participaram 491 alunos (idade de 11 a 16 anos), selecionados por conveniência, de ambos os sexos, que frequentavam os três últimos anos do Ensino Fundamental de escolas públicas e particulares de uma cidade do Estado de Minas Gerais. Os participantes responderam ao Inventário de Habilidades Sociais para Adolescentes, ao Children’s Self-Efficacy Scale, ao Questionário de Clima Escolar e ao Questionário com informações demográficas. Os resultados indicaram que as meninas apresentaram mais autoeficácia para atividades extracurriculares/lazer e social e mais empatia e assertividade do que os meninos. Os alunos apresentaram mais habilidades sociais de abordagem social/sexual e perceberam mais o clima escolar acerca do relacionamento entre estudantes. Estudantes com histórico de reprovação escolar tiveram menor autoeficácia e clima escolar positivo. Os dados evidenciaram as influências dos papéis de gênero e da reprovação escolar sobre as relações interpessoais e o desempenho escolar dos estudantes ao final do Ensino Fundamental, destacando a necessidade de se fomentar programas de intervenção com alunos e professores.
The right to euthanasia in the context of the realization of the right to life
Authors: Nikitenko L.O. , Babyk M.K. 
Published: October 2021

The article examines the concept of euthanasia, the main scientific doctrines, which determine the attitude of legal experts to this phenomenon, and the reasons for the theory about the need to establish the right to euthanasia as the form of realization of the right to die in Ukrainian legislation and at the international level.Theproblemofthecontroversy of the concept that recognizes the existence of the fourth generation of human rights to which the right to euthanasia belongs is covered. It is determined that there are some disputes in scientific circles caused by theemergence of a new generation of rights. It is also determined that the new generation of rights is quite debatable, as it destroys the established classification of human rights.The concept of euthanasia is studied, the main distinguishing features between active and passive forms of the implementation of this phenomenon are characterized. It is identified that the majority of disputes about euthanasia legalizing is related to the implementation of its active form.
Based on the research of scientists’ positions from different fields of science on the possibility of legalizing euthanasia, the two main views have been identified: for legalizing euthanasia and against it.It has been found that the basis for the difference of opinion on this issue is the controversy of the right to euthanasia in the context of the constitutional human right to life.The case-law of the European Court of Human Rights in issues related to euthanasia is analyzed. The comparison of the two decisions of the Court has been made and on this basis the peculiarities of the regulation of this problem in the international arena are clarified.The positive and negative aspects of the implementation of the right to euthanasia are analyzed.The possibility of establishng the right to die at the state and international levels is considered, its contradiction to the right to life, which is enshrined in the Constitution of Ukraine, as well as in the Declaration of Human and Civil Rights, is justified. The emphasis is placed on the need to develop medicine in order to prevent cases that could lead to the use of euthanasia.Taking into consideration the number and importance of negative factors in euthanasia implementation and the general unwillingness of society to legalize such a right, the conclusion that justified the inadvisability of enshrining the right to euthanasia in the legislation of Ukraine has been developed.
Turning Socio-Political Risk to Your Brand’s Advantage
Authors: Fournier Susan , Srinivasan Shuba , Marrinan Patrick 
Published: October 2021

Abstract
Employment practices, civic responsibilities, philanthropy, environmental stewardship, the conduct of corporate executives and employees, the execution of marketing campaigns: All these topics can trigger brand risk events. The challenging branding environment calls for reimagining classic brand marketing through a refreshed and updated social risk management lens. Companies need to assess which socio-economic marketing opportunities can renew brand resonance. This involves not just identifying revenue generating opportunities, but also identifying, cataloging, and tracking SEP risk types in order for managers to understand the new landscape brands must now navigate. Then, they need to implement a framework to manage a brand’s social risks and to take advantage of potential opportunities. Fully embracing this responsibility changes the marketing executive’s role in a significant way: From top line revenue generation to a dual role that includes managing risks as well as returns.
Purpose Beyond Profit: Things That Matter When Millennials Go Job Hunting
Authors: Buder Fabian , Kittinger-Rosanelli Christine 
Published: October 2021

Abstract
In a survey of future leaders, Millennials answered what motivates them in their careers. Having a positive impact on society was the most important measure for career success, followed by working on interesting and fascinating projects. The classical measures of career success such as a high salary, extensive decision-making authority, leading a large team or power over people were reported to be much less important. A significant proportion of the respondents said they decided not to apply for initially interesting job openings or even turned down interesting job offers if an employer did not fit their values. The Leaders of Tomorrow see a need for lasting change that effects all operations and traditional business models. Companies that fail to increase their efforts now may risk “missing the boat” for the future. Those who fail to establish a purpose beyond profit will shrink their talent pool.
A modest method of synthesis Cu- based metal-organic frameworks using benzene dicarbocxylate as a ligan for promising candidate of flue gas CO2 adsorption
Authors: MUTTAQIN MUTTAQIN , HIDAYAT FARID IMAM 
Published: October 2021

Metal organic framework (MOF) is one of extraordinary materials in many technical field applications. One of them is as CO2 gas adsorbent. We studied, synthesized, and characterized Copper-based material, known as Metal organic frameworks (MOFs), using a solvothermal-based modification method. Copper salt (Cu (NO3)2. 3H2O) and benzene dicarboxylic acid (H2BDC) were mixed and then heated in an oven at 120°C, to produce low impurities, small pore and uniform particle size of materials called CuBDC. Infrared spectroscopy and XRD data confirmed the formation of CuBDC. Furthermore, the result showed that CuBDC frameworks have good thermal stability up to 330°C. Thereafter SEM picture showed random, layered, and asymmetrical corners structure which is typical of triclinic crystal system. Lastly, specific surface areas and the porosity were analyzed using The Brunauer-Emmett-Teller (BET) method. It recorded 485 m2.g-1 of surface area while average pore volume and average pore size are 0.16 cm3.g-1 and 5.9 Å respectively. @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536869121 1107305727 33554432 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; mso-ansi-language:IN; mso-fareast-language:IN;}div.WordSection1 {page:WordSection1;}
The Mosaic Floors of the House of Kyrios Leontis in Nysa Scythopolis (Beth Shean)
Authors: HABAS Lihi 
Published: October 2021

The House of Kyrios Leontis in Nysa Scythopolis (Beth-Shean) was partially excavated by two expeditions and at different times, and the mosaic floors have been published only in preliminary publications. Two halls were discovered in the complex. The first hall is decorated with a mosaic pavement of three panels: the Homeric story of Odysseus and the Sirens; beribboned parrots surrounding a dedication inscription; the Nile god, Nilometer, the city of Alexandria, and a Nilotic landscape. The second hall served as a prayer room or a small synagogue. A pair of animals decorated the two entrances, and the hall itself is decorated with populated vine scrolls with animals. Jewish ritual objects appear in the central medallion: the seven-branched candlestick, citron, censer, and ram’s horn. The mosaic floors are inlaid with dedication inscriptions in Hebrew, Aramaic and Greek, with the names of the donors and prayers for the holy congregation.
The iconography, incorporating mythological subjects, the god of the Nile and Nilotic landscape, Jewish ritual objects, common animal chase scenes, and the use of the three languages that were customary in Byzantine Palestine, expresses the character of the city of Nysa Scythopolis as a cultural city inhabited by a mixed, well-educated population.
Pedagogías del don: solidaridad y subjetivación en transmigrantes centroamericanos en México
Authors: Parrini Rodrigo , Alquisiras Luisa , Nocedal Emilio 
Published: October 2021

Este artículo busca hacer una descripción y un análisis de las prácticas y las narrativas en torno al acto de pedir, por parte de personas migrantes de origen centroamericano que transitan irregularmente por México. Los autores denominan pedagogías del don al proceso cotidiano en el que los migrantes enseñan y aprenden a solicitar ayuda para sobrevivir durante sus viajes. Asimismo, hacen alusión a las orientaciones éticas que suscitan dichas pedagogías, así como a las performances corporales e intersubjetivas que se despliegan. En las conclusiones, los autores señalan que las pedagogías del don enseñan esquemas de relacionamiento que se ligan también a retóricas del pedir..
Religious Peace building, the Problems, and Potentials Now and in the Foreseeable Federal Republic of Nepal
Authors: Suvedi Mukti 
Published: October 2021

Introduction: There is debate whether most Nepali people still want Nepal to be a Hindu state. A significant number of opinions wish to see the country as secular, where people are respected with dignity without any discrimination where people can profess, practice, and protect their religions, whichever religion it may be.
Methods: This paper is based on public opinion surveys through interviews and discussions with100 individuals, including key informant interviews with 25 religious leaders from different religions conducted between September 20019 and February 2020 and secondary data from various literature reviews.
Results: The paper's finding reveals that the public's preference toward the Hindu state is not accepted in all sub-national levels; a secular state preference is evident in some of the sub-national levels, which cannot be undervalued. The mindsets of most of the elder populations interviewed still want Nepal to be the only Hindu state in the world, whereas the active young-age (youth) population is more inclusive and is happy with the secular nation.
Conclusion: Understanding and implementing inclusive secular policies and practicing the preexistence principles of religious freedom by the political parties and incorporating the same in all government, semi-government and private sectors will ensure a secular and peaceful Nepal. Government authorities and other bureaucrats becoming more sensitive towards religious issues will create space for promoting peace.
PENGARUH SELEBRITY ENDORSER, CITRA MEREK DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN KOSMETIK WARDAH (STUDI KASUS MAHASISWI ASRAMA UNDHARI)
Authors: Munawaroh Munawaroh , Gusteti Yesi , Resty Fenesy 
Published: October 2021

Penelitian ini dilakuan untuk mengetahui dan menganalisis seperti apa dampak yang ditimbulkan oleh celebrity endorser, citra merek dan harga terhadap keputusan pembelian kosmetik wardah pada mahasiswi asrama Undhari. Tujuan penelitian ini dilakukan untuk mengetahui dan menganalisis “Pengaruh celebrity endorser, citra merek dan harga terhadap keputusan pembelian kosmetik wardah” (studi kasus mahasiswi asrama Undhari). Penelitian ini menggunakan metode kuantitantif, teknik pengembilan sampel menggunakan non proaility sampling pengambilan data menggunakan kuesioner, responden yang di jadikan sampel adalah sebanyak 105 reponden. Hasil dari penelitian ini menunjukan bahwa secara parsial dan simultan terbukti bahwa celebrity endorser, citra merek dan harga berpengaruh secara signifikan terhadap keputusan pembelian. Nilai Adjusted R Square nya adalah 0,789 yang berarti semua variable independen dapat menjelaskan sebesar 78,9% terhadap variable dependen. Sementara sisanya 21,1% dapat dijelaskan oleh faktorl ainnya yang tidak diuji dalam penelitian ini. Kata Kunci : celebrity endorser, citra merek, harga, keputusan pembelian
Tularaemia: a case report and review
Authors: Mejza F , Kruczak K , Sładek K 
Published: October 2021

<p><strong>ABSTRACT</strong><br />Tularaemia is a rare infectious disease caused by <em>Francisella tularensis</em>. In Poland, <em>F. tularensis</em> infections are caused by <em>F. tularensis subspecies holarctica</em> (type B). The disease is widespread among multiple animal species. Humans are usually infected via insect bites and less commonly by other routes (contact with animals, inhalation of contaminated aerosol or dust, or oral route). In recent years, the prevalence of tularaemia in Poland was slightly more than dozen cases per year. Depending on the route of infection, the disease has various clinical presentations, of which the most common is the ulceroglandular form. We present a typical case of this clinical form, along with information on epidemiology, clinical presentation, diagnosis, and treatment of this rare disease. Because of a low prevalence and miscellaneous clinical features, the diagnosis is often delayed.<br />Tularaemia should be included in the differential diagnosis of fever with local lymph node enlargement as well as atypical cases of upper airway infections and pneumonia.</p>
<p><strong>STRESZCZENIE</strong><br />Tularemia jest rzadką chorobą zakaźną, powodowaną przez zakażenie <em>Francisella tularensis</em>. W Polsce zakażenia powoduje podgatunek <em>F. tularensis subspecies holoarctica</em> (typ B). Tularemia jest rozpowszechniona wśród wielu gatunków zwierząt. Do zakażenia ludzi dochodzi najczęściej wskutek przeniesienia bakterii przez ugryzienie owada, rzadziej innymi drogami (kontakt z zakażonym zwierzęciem, inhalacja zakażonego aerozolu lub pyłu albo drogą doustną). Częstość choroby w Polsce w ostatnich latach to około kilkunastu przypadków rocznie. W zależności od drogi zakażenia tularemia ma wiele postaci, z których najczęstsza to wrzodziejąco-węzłowa. W artykule opisano typowy przypadek tej postaci tularemii, jak również przedstawiono informacje na temat epidemiologii, postaci klinicznych, diagnostyki i leczenia tej rzadkiej choroby. Ze względu na małą częstość występowania i różnorodny obraz kliniczny rozpoznanie często bywa opóźnione, dlatego należy pamiętać o uwzględnieniu tularemii w diagnostyce różnicowej m.in. gorączki z lokalnym powiększeniem węzłów chłonnych, jak również atypowych infekcji górnych dróg oddechowych i płuc.</p>
Mendongeng Digital sebagai Media Peningkatan Soft Skill Santri Sanggar Baca Jendela Dunia
Authors: Latifah Latifah , Anggraini Indrani Dewi , Sariasih Wiwit , Perlina Mia 
Published: October 2021

Sanggar Baca Jendela Dunia (SBJD) yang berlokasi di RT 01 RW 02 Legoso Ciputat Timur didirikan atas dasar keprihatinan terhadap rendahnya minat baca anak-anak di lingkungan setempat. Atas pertimbangan hal tersebut, SBJD pun kemudian berupaya untuk meningkatkan kemampuan literasi anak-anak. Oleh karena itu, kegiatan PkM ini bertujuan untuk meningkatkan soft skill sekaligus mendorong dan meningkatkan kemampuan literasi digital melalui variasi kegiatan yang edukatif dan menyenangkan untuk menarik minat para peserta didik/santri SBJD. Metode yang digunakan dalam kegiatan PkM ini dilaksanakan melalui kegiatan mendongeng digital yang dikembangkan melalui diskusi, bermain, dan bernyanyi. Selain itu, asesmen dilakukan dengan memanfaatkan aplikasi whiteboard.fi yang menuntun para santri memperoleh pengetahuan dan keterampilan terkait digital literasi. Kegiatan PkM diikuti oleh 30 santri dengan rentang usia 4-12 tahun. Dari hasil kegiatan PkM, para santri mengikuti rangkaian kegiatan dengan antusias tinggi dan ceria. Kemampuan literasi para santri ditunjukkan dengan penggunaan Zoom sebagai media pelaksanaan kegiatan, Power Point sebagai media presentasi dongeng dan materi penguatan dan pengembangan tentang dongeng, serta asesmen dengan aplikasi Whiteboard.fi yang memungkinkan para santri untuk bereksperimen. Selain itu, melalui dongeng yang disampaikan, para peserta juga mendapat pendidikan karakter sehingga terbentuknya rasa percaya diri, menjadi pribadi yang bersyukur, dan saling menghormati.
Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models
Authors: Xie Jialiu , Cho Hunyong , Lin Bridget M. , Pillai Malvika , Heimisdottir Lara H. , Bandyopadhyay Dipankar , Zou Fei , Roach Jeffrey , Divaris Kimon , Wu Di 
Published: October 2021

Microbiome data are becoming increasingly available in large health cohorts, yet metabolomics data are still scant. While many studies generate microbiome data, they lack matched metabolomics data or have considerable missing proportions of metabolites. Since metabolomics is key to understanding microbial and general biological activities, the possibility of imputing individual metabolites or inferring metabolomics pathways from microbial taxonomy or metagenomics is intriguing. Importantly, current metabolomics profiling methods such as the HMP Unified Metabolic Analysis Network (HUMAnN) have unknown accuracy and are limited in their ability to predict individual metabolites. To address this gap, we developed a novel metabolite prediction method, and we present its application and evaluation in an oral microbiome study. The new method for predicting metabolites using microbiome data (ENVIM) is based on the elastic net model (ENM). ENVIM introduces an extra step to ENM to consider variable importance (VI) scores, and thus, achieves better prediction power. We investigate the metabolite prediction performance of ENVIM using metagenomic and metatranscriptomic data in a supragingival biofilm multi-omics dataset of 289 children ages 3–5 who were participants of a community-based study of early childhood oral health (ZOE 2.0) in North Carolina, United States. We further validate ENVIM in two additional publicly available multi-omics datasets generated from studies of gut health. We select gene family sets based on variable importance scores and modify the existing ENM strategy used in the MelonnPan prediction software to accommodate the unique features of microbiome and metabolome data. We evaluate metagenomic and metatranscriptomic predictors and compare the prediction performance of ENVIM to the standard ENM employed in MelonnPan. The newly developed ENVIM method showed superior metabolite predictive accuracy than MelonnPan when trained with metatranscriptomics data only, metagenomics data only, or both. Better metabolite prediction is achieved in the gut microbiome compared with the oral microbiome setting. We report the best-predictable compounds in all these three datasets from two different body sites. For example, the metabolites trehalose, maltose, stachyose, and ribose are all well predicted by the supragingival microbiome.