bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Co-Construction of Learning Environments at the Boundary of School and Work Through the Lens of Vocational Practice
Authors: Bouw Erica , Zitter Ilya , de Bruijn Elly 
Published: July 2021

AbstractEducational institutions and vocational practices need to collaborate to design learning environments that meet current-day societal demands and support the development of learners’ vocational competence. Integration of learning experiences across contexts can be facilitated by intentionally structured learning environments at the boundary of school and work. Such learning environments are co-constructed by educational institutions and vocational practices. However, co-construction is challenged by differences between the practices of school and work, which can lead to discontinuities across the school–work boundary. More understanding is needed about the nature of these discontinuities and about design considerations to counterbalance these discontinuities. Studies on the co-construction of learning environments are scarce, especially studies from the perspective of representatives of work practice. Therefore, the present study explores design considerations for co-construction through the lens of vocational practice. The study reveals a variety of discontinuities related to the designable elements of learning environments (i.e. epistemic, spatial, instrumental, temporal, and social elements). The findings help to improve understanding of design strategies for counterbalancing discontinuities at the interpersonal and institutional levels of the learning environment. The findings confirm that work practice has a different orientation than school practice since there is a stronger focus on productivity and on the quality of the services provided. However, various strategies for co-construction also seem to take into account the mutually beneficial learning potential of the school–work boundary.
A patient with liver cirrhosis and hepatic lesions
Authors: Meischl Tobias , Tamandl Dietmar , Pinter Matthias 
Published: July 2021

SummaryWe report an unusual case of a cirrhotic patient with two different types of hepatic lesions: Eventually, the patient was diagnosed with hepatocellular carcinoma and hepatic splenosis. Possible diagnostic strategies and the differentiation between these two entities are discussed.
Toward the recognition of spacecraft feature components: A new benchmark and a new model
Authors: Qiu Linwei , Tang Liang , Zhong Rui 
Published: July 2021

AbstractCountries are increasingly interested in spacecraft surveillance and recognition which play an important role in on-orbit maintenance, space docking, and other applications. Traditional detection methods, including radar, have many restrictions, such as excessive costs and energy supply problems. For many on-orbit servicing spacecraft, image recognition is a simple but relatively accurate method for obtaining sufficient position and direction information to offer services. However, to the best of our knowledge, few practical machine-learning models focusing on the recognition of spacecraft feature components have been reported. In addition, it is difficult to find substantial on-orbit images with which to train or evaluate such a model. In this study, we first created a new dataset containing numerous artificial images of on-orbit spacecraft with labeled components. Our base images were derived from 3D Max and STK software. These images include many types of satellites and satellite postures. Considering real-world illumination conditions and imperfect camera observations, we developed a degradation algorithm that enabled us to produce thousands of artificial images of spacecraft. The feature components of the spacecraft in all images were labeled manually. We discovered that direct utilization of the DeepLab V3+ model leads to poor edge recognition. Poorly defined edges provide imprecise position or direction information and degrade the performance of on-orbit services. Thus, the edge information of the target was taken as a supervisory guide, and was used to develop the proposed Edge Auxiliary Supervision DeepLab Network (EASDN). The main idea of EASDN is to provide a new edge auxiliary loss by calculating the L2 loss between the predicted edge masks and ground-truth edge masks during training. Our extensive experiments demonstrate that our network can perform well both on our benchmark and on real on-orbit spacecraft images from the Internet. Furthermore, the device usage and processing time meet the demands of engineering applications.
“What Are You Looking For?” Investigating the Association Between Dating App Use and Sexual Risk Behaviors
Authors: Flesia Luca , Fietta Valentina , Foresta Carlo , Monaro Merylin 
Published: July 2021

Abstract

Introduction
Literature on the association between dating app use and sexual risk behaviors is still scant and inconclusive.

Aim
To investigate the association between dating app use and sexual risk behaviors, considering the role of motives for using them.

Methods
1,278 Italian respondents completed an online questionnaire assessing demographics, motives and patterns of dating app use, sexual behaviors and sexually transmitted infections (STIs) diagnoses. One-way ANOVA and Chi-squared analyses were used to investigate differences among the three subsamples (active vs former vs non-users). Multiple linear and logistic regression analyses were run to investigate the role of demographics, motives and patterns of dating app use on sexual risk taking and sexual health.

Main outcome measures
Number of protected and unprotected full sexual partners in the last year; frequency of hook-ups in the last year; STIs lifetime.

Results
Active users, even more than former app users, were more likely to report risky behaviors and STI diagnoses than non-users (χ2 = 26.37, P &lt; .001). Installing the apps to find friends or romantic partners was associated with less protected (find friends B = −0.364, P = .015; find romantic partners B = −0.300, P = .006) and unprotected (find friends B = −0.346, P = .016; find romantic partners B = −0.360, P &lt; .001) sexual intercourses. Installing the apps to find sexual partners predicted higher odds of unprotected sexual activity (B = 0.193, P = .048), hook-ups (B = 0.496, P &lt; .001) and STIs diagnoses (OR = 2.835, P = .025). Accessing apps more frequently and more years of usage was associated with reporting risky sexual behaviors and STI diagnoses among active users (app access frequency OR = 1.461, P = .003; usage years OR = 1.089, P = .013).

Conclusion
Installing the apps to search for sexual partners, using them at length since first installation and accessing them frequently are significant factors in influencing the association between dating app use and sexual risk behaviors. Flesia L, Fietta V, Foresta C, Monaro M. “What Are You Looking For?” Investigating the Association Between Dating App Use and Sexual Risk Behaviors. Sex Med 2021;9:100405.
Handwritten in Lagos: Selfhood and Textuality in Colonial Petitions
Authors: Decker Tunde 
Published: July 2021

AbstractThis paper asks a methodological question: In what way can petitions written in the colonial period introduce us to the persona of the writers – that is, as against mainstream interpretation given to them as mere archival sources? Doesn’t the very nature of the petitions introduce us to the selfhood of those “caught up” in the often-mentioned “sophisticated” concepts of nationalism, politics, power, imperialism, urbanity, and colonialism? What, and how, do petitions tell us about the “interior version” of colonial society as seen in the individual? In an attempt at a deeper understanding of colonial Lagos, this paper examines an alternative feature of petitions as entry into the selfhood of colonial subjects rather than mainstream interpretations of the documents as qualitative exposition to “grand” historical phenomena. Selfhood as examined here is presented as it was constructed by petitions written in Lagos between 1940 and 1960 with a particular focus on three. Their deficiencies in “standards of grammar” notwithstanding, the words are also examined to allow for a demonstration of their qualities as texts: their meanings in singular and collaborative contexts, the gaps they exposed, the information they concealed, the disconnections in chronology they indicated, the “ethics” of grammar they “relegated” for more “substantial expose” of the self, the information they privileged the reader to hear, the identity they formed in the personas they constructed and the voice they generated. This paper suggests that these strands analyzed together affirm the textuality of petitions written by everyday people in colonial Lagos and that these point to the potentiality of such documents to further contribute to the substantial comprehension of the inner qualities of self-identity in Lagos and Nigeria’s colonial history.
The origins of the negative historical representations of burghers in Hungary
Authors: Czoch Gábor 
Published: July 2021

AbstractHungarian historiography needs to review its negative representation of towns and burghers typical of the first half of nineteenth-century Hungary, as Vera Bácskai, a major figure of Hungarian urban history suggested in a paradigmatic paper. Starting from her statements, this article examines the historical narratives of secondary school textbooks and wider historical syntheses of Hungarian history published in the age of Austria-Hungary (1867–1918). The author shows that the burghers’ negative image was rooted in the political fights prior to the 1848 Revolution and the emergence of modern nationalism.
Vera Bácskai and her significance in the development of European urban history: a personal account
Authors: Clark Peter 
Published: July 2021

AbstractThis account of Vera Bacskai's contribution to European urban history after 1990 is a personal narrative, written by a friend and collaborator. It argues that her role was multi-dimensional. It was founded on her major publications on Budapest and small towns, shedding a crucial East Central European light on European urbanization. It was underpinned by her participation in various international projects like the EU TEMPUS programme which created strong institutional bonds with Western universities as well as opportunities for Hungarian students through exchange programmes, international workshops and the like. Not least, she was a strong pillar in the construction of the European Association for Urban History. When she joined the committee in 1991, it was still an embryonic body. In 1996, she organized the successful and important Budapest conference. When she retired from EAUH in 2004, its conferences were attracting many hundreds of researchers, from across Europe and beyond.
Analytical Solutions for Fresh Groundwater Lenses in Small Strip Islands With Spatially Variable Recharge
Authors: Tang Yuening , Yan Min , Wang Xiaoxiong , Lu Chunhui , Luo Jian 
Published: July 2021

AbstractGroundwater lens may provide the primary freshwater supply for the inhabitants of small islands. The lens profile and volume are sensitive to spatially variable recharge caused by topography, soil type, land cover, evapotranspiration and human activities. We derive analytical solutions based on the sharp‐interface approximation to describe transient and steady‐state lens profiles for spatially variable recharge rates in small strip islands. The derived solutions are validated by a steady‐state solution for simple spatial recharge patterns and numerical simulations. Numerical investigations show that the spatial recharge pattern has a significant impact on the lens profile. For a given constant total recharge, smaller recharge areas or a more concentrated recharge rate can result in a larger lens volume. The volume increase can be over 20% compared with the lens volume of a uniform recharge. For the steady‐state lens profile corresponding to a point recharge, the squared lens thickness peaks at the recharge location and linearly decreases to the boundary, resulting in a triangle shape for the profile of squared lens thickness. Moreover, compared with recharges in other locations, recharge in a small area at the domain center has the greatest impact. Uncertainty analysis can be conveniently implemented based on the derived analytical solution to investigate the lens behavior under spatially variable recharge with uncertainties. Results show that the lens volume tends to have a larger variance for a recharge rate with a higher variance and longer correlation length.
Importance of Parameter and Climate Data Uncertainty for Future Changes in Boreal Hydrology
Authors: Marshall Adrienne M. , Link Timothy E. , Flerchinger Gerald N. , Lucash Melissa S. 
Published: July 2021

AbstractSoil moisture and evapotranspiration (ET) are important components of boreal forest hydrology that affect ecological processes and land‐atmosphere feedbacks. Future trends in soil moisture in particular are uncertain. Therefore, accurate modeling of these dynamics and understanding of concomitant sources of uncertainty are critical. Here, we conduct a global sensitivity analysis, Monte Carlo parameterization, and analysis of parameter uncertainty and its contribution to future soil moisture and ET uncertainty using a physically based ecohydrologic model in multiple boreal forest types. Soil and plant hydraulic parameters and LAI have the largest effects on simulated summer soil moisture at two contrasting sites. In future scenario simulations, the selection of parameters and global climate model (GCM) choice between two GCMs influence projected changes in soil moisture and ET about as much as the projected effects of climate change in the less sensitive GCM with a late‐century, high‐emissions scenario, though the relative effects of parameters, GCM, and climate vary among hydrologic variables and study sites. Saturated volumetric water content and sensitivity of stomatal conductance to vapor pressure deficit have the most statistically significant effects on change in ET and soil moisture, though there is considerable variability between sites and GCMs. The results of this study provide estimates of: (a) parameter importance and statistical significance for soil moisture modeling, (b) parameter values for physically based soil‐vegetation‐atmosphere transfer models in multiple boreal forest types, and (c) the contributions of uncertainty in these parameters to soil moisture and ET uncertainty in future climates.
Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway
Authors: Zhang Yujing , Shi Gang , Zhang Hantao , Xiong Qi , Cheng Fuyi , Wang Huiling , Luo Jieyan , Zhang Yong , Shi Pengyi , Xu Jia , Fu Jiamei , Chen Na , Cheng Lin , Li Yiming , Dai Lei , Yang Yang , Yu Dechao , Zhang Shuang , Deng Hongxin 
Published: July 2021

AbstractDexamethasone (Dex), as a pretreatment agent, is widely used to attenuate the side effects of chemotherapy in breast cancer treatment. However, whether and how Dex affects breast cancer metastasis remain to be furtherly understood. In this study, we established several mouse breast cancer metastatic models to study the effect of Dex in vitro and in vivo. Transwell, Western Blot and RNA interference were applied to study the molecular mechanism of Dex in promoting breast cancer cell migration. Meanwhile, the effect of Dex on lung metastasis of breast cancer in Dex combined with PTX chemotherapy was discussed. Our results confirmed that Dex could promote breast cancer cell metastasis both in vitro and in vivo. Mechanistic studies revealed that this pro-metastatic effect of Dex was mediated by the GR-PI3K-SGK1-CTGF pathway in tumor cells. Ligation of Dex and glucocorticoid receptor (GR) on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 (SGK1) expression, and then increased the expression of connective tissue growth factor (CTGF) through Nedd4l-Smad2. Moreover, Dex was the leading factor for lung metastasis in a standard regimen for breast cancer treatment with paclitaxel and Dex. Importantly, targeting SGK1 with the inhibitor GSK650394 remarkably reduced lung metastasis in this regimen. Our present data provide new insights into Dex-induced breast cancer metastasis and indicate that SGK1 could be a candidate target for the treatment of breast cancer metastasis.
An ERG and OCT study of neuronal ceroid lipofuscinosis CLN2 Battens retinopathy
Authors: Thompson Dorothy A. , Handley Siân E. , Henderson Robert H. , Marmoy Oliver R. , Gissen Paul 
Published: July 2021

Abstract
Background
Late infantile neuronal ceroid lipofuscinosis (CLN2 Batten disease) is a rare, progressive neurodegenerative disease of childhood. The natural history of motor and language regression is used to monitor the efficacy of CNS treatments. Less is known about CLN2 retinopathy. Our aim is to elaborate the nature, age of onset, and symmetry of CLN2 retinopathy using visual electrophysiology and ophthalmic imaging.

Subjects and methods
We reviewed 22 patients with genetically confirmed CLN2 disease; seventeen showing classical and five atypical disease. Flash electroretinograms (ERGs), flash and pattern reversal visual evoked potentials (VEPs), recorded from awake children were collated. Available fundus images were graded, optical coherence tomography (OCT) central subfoveal thickness (CST) measured, and genotype, age, clinical vision assessment and motor language grades assembled.

Results
ERGs show cone/rod system dysfunction preceded by localised macular ellipsoid zone disruption on OCT from 4.8 years. Electroencephalogram (EEG) time-locked spikes confounded both pattern 6/17 (35%) and flash VEPs 12/16 (75%). Paired right eye (RE) and left eye (LE) ERG amplitudes did not differ significantly for each flash stimulus at the p 0.001 level, Wilcoxon ranked signed test. Cone ERGs show a functional deficit before CST thinning in classical disease. Optomap hyper fundus autofluorescence (FAF) at the fovea was noted in three patients with normal ERGs. The oldest patient showed an ovoid aggregate above the external limiting membrane at the fovea, which did not affect the PERG.

Conclusion
ERG findings in CLN2 retinopathy show symmetrical cone-rod dysfunction, from 4y10m in this series, but a broad range of ages when ERG function is preserved.
Sex, gender, and retinoblastoma: analysis of 4351 patients from 153 countries
Authors: Fabian Ido Didi , Khetan Vikas , Stacey Andrew W. , Allen Foster  , Ademola-Popoola Dupe S. , Berry Jesse L. , Cassoux Nathalie , Chantada Guillermo L. , Hessissen Laila , Kaliki Swathi , Kivelä Tero T. , Luna-Fineman Sandra , Munier Francis L. , Reddy M. Ashwin , Rojanaporn Duangnate , Blum Sharon , Sherief Sadik T. , Staffieri Sandra E. , Theophile Tuyisabe , Waddell Keith , Ji Xunda , Astbury Nicholas J. , Bascaran Covadonga , Burton Matthew , Zondervan Marcia , Bowman Richard ,   On behalf of the Global Retinoblastoma Study Group
Published: July 2021

Abstract
Objective
To investigate in a large global sample of patients with retinoblastoma whether sex predilection exists for this childhood eye cancer.

Methods
A cross-sectional analysis including 4351 treatment-naive retinoblastoma patients from 153 countries who presented to 278 treatment centers across the world in 2017. The sex ratio (male/female) in the sample was compared to the sex ratio at birth by means of a two-sided proportions test at global level, country economic grouping, continent, and for selected countries.

Results
For the entire sample, the mean retinoblastoma sex ratio, 1.20, was higher than the weighted global sex ratio at birth, 1.07 (p < 0.001). Analysis at economic grouping, continent, and country-level demonstrated differences in the sex ratio in the sample compared to the ratio at birth in lower-middle-income countries (n = 1940), 1.23 vs. 1.07 (p = 0.019); Asia (n = 2276), 1.28 vs. 1.06 (p < 0.001); and India (n = 558), 1.52 vs. 1.11 (p = 0.008). Sensitivity analysis, excluding data from India, showed that differences remained significant for the remaining sample (χ2 = 6.925, corrected p = 0.025) and for Asia (χ2 = 5.084, corrected p = 0.036). Excluding data from Asia, differences for the remaining sample were nonsignificant (χ2 = 2.205, p = 0.14).

Conclusions
No proof of sex predilection in retinoblastoma was found in the present study, which is estimated to include over half of new retinoblastoma patients worldwide in 2017. A high male to female ratio in Asian countries, India in specific, which may have had an impact on global-level analysis, is likely due to gender discrimination in access to care in these countries, rather than a biological difference between sexes.
In vitro efficacy of artemisinin-based treatments against SARS-CoV-2
Authors: Zhou Yuyong , Gilmore Kerry , Ramirez Santseharay , Settels Eva , Gammeltoft Karen A. , Pham Long V. , Fahnøe Ulrik , Feng Shan , Offersgaard Anna , Trimpert Jakob , Bukh Jens , Osterrieder Klaus , Gottwein Judith M. , Seeberger Peter H. 
Published: July 2021

AbstractEffective and affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are needed. We report in vitro efficacy of Artemisia annua extracts as well as artemisinin, artesunate, and artemether against SARS-CoV-2. The latter two are approved active pharmaceutical ingredients of anti-malarial drugs. Concentration–response antiviral treatment assays, based on immunostaining of SARS-CoV-2 spike glycoprotein, revealed that treatment with all studied extracts and compounds inhibited SARS-CoV-2 infection of VeroE6 cells, human hepatoma Huh7.5 cells and human lung cancer A549-hACE2 cells, without obvious influence of the cell type on antiviral efficacy. In treatment assays, artesunate proved most potent (range of 50% effective concentrations (EC50) in different cell types: 7–12 µg/mL), followed by artemether (53–98 µg/mL), A. annua extracts (83–260 µg/mL) and artemisinin (151 to at least 208 µg/mL). The selectivity indices (SI), calculated based on treatment and cell viability assays, were mostly below 10 (range 2 to 54), suggesting a small therapeutic window. Time-of-addition experiments in A549-hACE2 cells revealed that artesunate targeted SARS-CoV-2 at the post-entry level. Peak plasma concentrations of artesunate exceeding EC50 values can be achieved. Clinical studies are required to further evaluate the utility of these compounds as COVID-19 treatment.