bluuebunny/crossref_metadata_2025_split huggingface dataset:
Febrile seizure incidence and age at first occurrence are associated with changes in placental normalized gene expression: the ‘3D’ pregnancy cohort study
Authors: Thébault‐Dagher Fanny , Robles Morgane , Herba Catherine M. , St‐Pierre Joey , Brochen Celia , Muckle Gina , Lupien Sonia J. , Séguin Jean R. , Fraser William D. , Vaillancourt Cathy , Lippé Sarah 
Published: September 2021

AbstractSelf‐reported maternal prenatal stress (MPS) has been associated with earlier febrile seizure (FS) age of onset in offspring. Studies are needed to understand how the biological systems associated with exposure to psychological MPS are linked to seizure disorders in children. The present study aimed to investigate whether placental markers of MPS are linked to FS incidence and age at first occurrence. A subsample of children with FS (n = 28) and matched controls (n = 84), were drawn from the longitudinal 3D pregnancy cohort (N = 2366 mother–child dyads). Expression of placental genes associated with glucocorticoids, serotonin and fetal/placental growth were analysed from placental tissues, compared between groups and associated with age at first FS. Overall placental normalized gene expression was statistically different (p < .001). Children with FS showed overexpression of the serotonin transporter (mean difference = 0.61, 95% confidence interval [CI] = 0.9–1.13), connexin 43 (mean difference = 0.69, 95% CI = 0.30–1.09), zonula occludens‐1 (mean difference = 0.84, 95% CI = 0.42–1.26) and underexpression of glucocorticoid receptor β (mean difference = 0.84, 95% CI = −1.49 to 0.19) and serotonin receptor 2B (mean difference = 1.57, 95% CI = −2.35 to 0.78) compared to controls. Increased expression of the serotonin transporter predicted 37.2% in variation of age at first FS. The correlation matrix showed pregnancy‐specific anxiety during the second trimester was moderately associated with age at first FS (r = −0.38) but was not a significant predictor in the regression model. Although our current results do not display a significant effect of self‐reported MPS on FS, the present study is the first to show that placental gene biomarkers usually known to be associated with MPS display different expressions in children with FS. Specifically, our results suggest that placental genes associated with the glucocorticoid, serotonergic and fetal/placental growth systems may be candidate mechanisms leading to increased vulnerability offspring in FS. Because self‐reported MPS was not found as a significant predictor in our statistical models, future studies are needed to investigate the mechanisms causing the observed changes in placental genes and their association with seizure disorders.
Spoiling for a fight: A relational model of daily work‐family balance satisfaction
Authors: Wan Min (Maggie) , Shaffer Margaret A. , Singh Romila , Zhang Yejun 
Published: September 2021

Previous studies demonstrate that both work and family factors explain employees’ work‐family balance satisfaction (WFBS); however, relatively less is known about the within‐person dynamics of WFBS on a daily basis. In this study, we adopt a relational perspective and draw on Cognitive and Affective Processing System and Conservation of Resources theories to clarify work and family relational influences on WFBS. First, we examine the effects of both work and family interpersonal conflict on WFBS through the mechanisms of employees’ negative work reflection and negative affective state. Second, we test whether job and family crafting behaviours, especially increasing job and family social resources, serve as personal resources that buffer the negative influences of work and family interpersonal conflict. Findings from our daily study indicate that negative work reflection mediates work interpersonal conflict and WFBS, while negative affect mediates family interpersonal conflict and WFBS. Interestingly, we only found support for the beneficial moderating role of increasing family social resources but not increasing job social resources. We discuss theoretical and practical implications as well as future research directions.Practitioner points

Organizations and practitioners should provide interventions (e.g., conflict resolution workshops, team‐building programs, or counselling services) that can resolve occurrences of work and family interpersonal conflict, thereby preventing its harmful role in daily work‐family balance satisfaction.

Managers may offer formal and informal support enhancing employees' daily relational crafting behaviours, especially increasing family social resources, which can mitigate the detrimental effect of family interpersonal conflict on work‐family balance satisfaction.
The widely distributed, edible seaweeds in Peru, Chondracanthus chamissoi and Chondracanthus chamissoi f. glomeratus (Gigartinaceae, Rhodophyta), are morphologically diverse but not phylogenetically distinct
Authors: Arakaki Natalia , Suárez‐Alarcón Sigfried , Márquez‐Corigliano Diego , Gil‐Kodaka Patricia , Tellier Florence 
Published: September 2021

AbstractChondracanthus chamissoi is part of the diet of coastal people from Peru and is exported dehydrated to Asian countries for direct consumption. Although it is considered endemic to Peru and Chile, its range has extended to distant regions, such as Korea, Japan, and France. Using morphological and molecular approaches, we examined specimens from Peru assigned to C. chamissoi (including the taxon of uncertain status Chondracanthus glomeratus) to improve phylogenetic and geographical information and characterize its morphological variability. Twenty‐one localities on the Peruvian coast were sampled, obtaining 102 COI and 27 rbcL sequences. To differentiate both entities, morphological characters such as thallus size, consistency, arrangement of main and secondary axes, branching patterns and location of reproductive structures, were analyzed on 46 specimens. While morphological characteristics are clearly contrasting among the two groups, both COI and rbcL phylogenies revealed a well‐supported clade with no genetic differentiation between the two morphologies. Therefore, the phylogenies indicate that C. chamissoi and C. glomeratus form a single taxonomic entity with high morphological variability, large geographic distribution and at least two morphological forms. The smaller form of C. chamissoi can be identified as C. chamissoi f. glomeratus. Such morphological variability can be of interest for future aquaculture development.
Habitat selection of Coot (Fulica atra) and Moorhen (Gallinula chloropus) in a remnant Mediterranean wetland (Italy): Implications for conservation
Authors: Talbi Awatif , Samraoui Farrah , Samraoui Boudjéma , Zullo Francesco , Battisti Corrado 
Published: September 2021

AbstractThe habitat selection of two abundant and widespread Palearctic rallids (Coot Fulica atra; Moorhen Gallinula chloropus) across a range of wetland types was investigated. The distribution of these two species varied according to water depth, as implied by the dominant vegetation present in the study area. Coots most frequently used wet dune slacks dominated by Phragmites australis, whereas Moorhens were mostly present in anthropized ecotones. It is hypothesized that because these two rallid species respond differently to various environmental pressures, they could be used as useful indicators for biomonitoring remnant wetlands. Indeed, they are relatively generalist, common, widespread and medium‐sized species, relatively easy to detect and exhibit a high sensitivity to specific water‐related habitat types, also at a small‐scaled spatial resolution.
Application of WASP model to simulate water pollution control of Duriangkang Dam
Authors: Wimordi Calvin , Yudianto Doddi , Guan Yiqing 
Published: September 2021

AbstractLocated in Batam City, Duriangkang Dam plays an essential role in providing clean water in the area, also being the first and largest estuary dam in Indonesia. However, with a total effective water volume of 107,000,000 m3, Duriangkang Dam is now heavily polluted because of enormous wastewater loads from both domestic and industrial sources that are directly discharged into the dam. The practice of fish farming has also contributed to its demise. Based on water samples collected during 2016 to 2018, the water condition for Duriangkang Dam is no longer classified as the 2nd class of raw water, based on Indonesian water standards. The present study utilizes the WASP model to evaluate and simulate possible solutions for controlling the Duriangkang Dam water pollution rate. The water quality indicators of dissolved oxygen (DO), total phosphorus (TP) and biochemical oxygen demand (BOD) concentrations are modelled. The calibration and verification results indicate the model exhibited an excellent fitting for DO, BOD and TP concentrations. Under several scenarios, it was determined that the best way to control the pollution rate within the dam is by implementing scenario 8, which include total control of the fish farms and domestic wastewater loads.
Optimal hydropower generation of Maithon multi‐purpose reservoir system
Authors: Sagar Priti , Parhi Prabeer Kumar , Bharti Birendra 
Published: September 2021

AbstractThe present study focuses on optimizing the hydropower generation capacity of a multi‐purpose reservoir system considering various constraints, including reservoir water mass balance, minimization of sediment, maximum and minimum reservoir water storage, maximum and minimum reservoir water releases, reservoir water drawdown levels, reservoir overflows, maximum flood zone space, and maximum and minimum storage constraints under 50%, 70% and 90% dependable inflow conditions The focus is the Maithon multi‐purpose reservoir system located at Maithon, a distance of 40.2 km from Dhanbad, the coal capital of India, in the State of Jharkhand. The study results indicate the derived policy is capable of producing maximum annual hydropower of 146,519.48 MWh/year for a 50% dependable inflow condition, 105,512.02 MWh/year for a 70% dependable inflow condition and 58,924.38 MWh/year for a 90% dependable inflow condition, compared to the existing hydropower generation of 129,428.4 MWh/year (average of last 10 years). A trade‐off between reservoir release water releases, mostly for meeting irrigation water needs and maximizing energy generation, was determined for use by various stakeholders and managers of reservoir operations.
Limitations and gaps in global bat wing morphology trait data
Authors: Crane Matt , Silva Inês , Grainger Matthew J. , Gale George A. 
Published: September 2021

Abstract

Species’ life‐history traits have a wide variety of applications in ecological and conservation research, particularly when assessing threats. The development and growth of global species’ trait databases are critical for improving trait‐based analyses; however, it is vital to understand the gaps and biases in the available data.

We reviewed bat wing morphology data, specifically mass, wingspan, wing area, wing loading, and aspect ratio, to identify issues with data reporting and ambiguity. Additionally, we aimed to assess taxonomic and geographic biases in trait data coverage.

We found that most studies used similar field methodology, but that data reporting and quality were inconsistent/poor. Additionally, we noted several issues regarding semantic ambiguity in trait definitions, specifically around what constitutes wing area.

Globally, we found that bat wing morphology trait coverage was low. Only six bat families had ≥40% trait coverage, and, of those, none consisted of more than 11 species in total. We found similar biases in trait coverage across International Union for Conservation of Nature Red List categories, with threatened species having lower coverage.

Geographically, North America, Europe, and the Indomalayan regions exhibited higher overall trait coverage, while both the Afrotropical and Neotropical ecoregions showed poor trait coverage.

The underlying biases and gaps in bat wing morphology data have implications for researchers conducting global trait‐based assessments. Implementing imputation techniques may address missing data, but only for smaller regional subsets with substantial trait coverage.

Due to generally low overall trait coverage, increasing species’ representation in the database should be prioritised. We suggest adopting an Ecological Trait Standard Vocabulary to reduce semantic ambiguity in bat wing morphology traits, to improve data compilation and clarity. Additionally, we advocate that researchers adopt an Open Science approach to facilitate the growth of a bat wing morphology trait database.
Potent T cell‐mediated anti‐inflammatory role of the selective CB2 agonist lenabasum in multiple sclerosis
Authors: Tiberi Marta , Evron Tama , Saracini Stefano , Boffa Laura , Mercuri Nicola Biagio , Chintalacharuvu Subba R. , Atamas Sergei P. , Chiurchiù Valerio 
Published: September 2021

AbstractBackgroundLenabasum is a synthetic cannabinoid receptor type‐2 (CB2) agonist able to exert potent anti‐inflammatory effects, but its role on T cells remains unknown.ObjectivesThe present study was undertaken to investigate anti‐inflammatory mechanisms of lenabasum in T lymphocyte subsets and its in vivo therapeutic efficacy in experimental autoimmune encephalomyelitis (EAE).MethodsMononuclear cells from 17 healthy subjects (HS) and 25 relapsing–remitting multiple sclerosis (RRMS) patients were activated in presence or absence of lenabasum and analysed by flow cytometry and qRT‐PCR. EAE mice were treated with lenabasum, and clinical score and neuroinflammation were evaluated.ResultsLenabasum significantly reduced TNF‐a production from CD4+ T cells and CD8+ T cells in a dose‐dependent manner in both HS and RRMS patients. In MS patients, lenabasum also reduced activation marker CD25 and inhibited IL‐2 production from both T cell subsets and IFN‐γ and IL‐17 from committed Th1 and Th17 cells, respectively. These effects were blocked by the pretreatment with selective CB2 inverse agonist SR144528. In vivo treatment of EAE mice with lenabasum significantly ameliorated disease severity, reduced neuroinflammation and demyelination in spinal cord.ConclusionLenabasum exerts potent T cell‐mediated immunomodulatory effects, suggesting CB2 as a promising pharmacological target to counteract neuroinflammation in MS.
Narrative care: Unpacking pandemic paradoxes
Authors: Caine Vera , Steeves Pamela , Berendonk Charlotte , Blix Bodil H. , Jean Clandinin D. 
Published: September 2021

AbstractDuring the coronavirus disease 2019 pandemic, public health has issued three interrelated dominant narratives through social media and news outlets: First, to care for others, we must keep physically distant; second, we live in the same world and experience the same pandemic; and third, we will return to normal at some point. These narratives create complexities as they collide with the authors' everyday lives as nurses, educators, and women. This collision creates three paradoxes for us: (a) learning to care by creating physical distance, (b) a sense of togetherness erases inequities, and (c) returning to normal is possible. To inquire into these three paradoxes, we draw on our experiences with Ingrid, an older adult who requires in‐home physical care, and Matthew, a man with multiple disabilities including severe oral dyspraxia and developmental delays. We outline how narrative care is a counterstory to the dominant narratives and enables us to find ways to live our lives within the paradoxes. Narrative care allows us, through attention to embodiment, liminality, and imagination, to create forward looking stories. Understanding narrative care within these paradoxes allows us to offer more complex understandings of the ways narrative care can be embodied in our, and others', lives.
Undergraduate researchers’ graduate school intentions during COVID‐19
Authors: Morales Danielle X. , Grineski Sara E. , Collins Timothy W. 
Published: September 2021

AbstractThere is emerging literature on the disruptive effects of the COVID‐19 pandemic on college students, but little is known about the impacts on undergraduate researchers (UGRs). On the basis of survey data collected in Summer 2020, this paper examines how less competent mentorship and COVID‐19–related difficulties shaped UGRs’ graduate school intentions. Results suggest that the pandemic strengthened UGRs’ graduate school intentions when UGRs experienced fewer COVID‐19–related difficulties. The pandemic weakened URG's graduate school intentions when they had a less competent faculty mentor. Having a more competent postgraduate mentor had a positive effect on UGRs’ graduate school intentions in response to the pandemic. Those findings indicate that higher quality postgraduate mentorship may serve as an effective surrogate for lower quality faculty mentorship. Findings suggest that immediate strategies are needed to bolster graduate school aspirations among specific groups of UGRs in response to the pandemic. UGRs of particular concern include those who were highly impacted by COVID‐19 with less competent mentors, were first‐generation college students, had less prior research experience, had their Summer 2020 research experiences canceled, and were social/behavioral sciences majors.
Comparison and reproducibility of three methods for maxillary digital dental model registration in open bite patients
Authors: Aliaga‐Del Castillo Aron , Vilanova Lorena , Janson Guilherme , Arriola‐Guillén Luis Ernesto , Garib Daniela , Miranda Felicia , Massaro Camila , Yatabe Marilia , Cevidanes Lucia , Ruellas Antonio Carlos 
Published: September 2021

AbstractObjectiveTo compare and assess the reproducibility of 3 methods for registration of maxillary digital dental models in patients with anterior open bite.Settings and sample populationDigital dental models of 16 children with an anterior open bite in the mixed dentition were obtained before (T1) and after 12 months of treatment with bonded spurs (T2).MethodsLandmarks were placed on all T2 models and 3 registration methods (R1, R2 and R3) were independently performed by 2 observers. R1 was based on 10 landmarks placed on posterior teeth. R2 was based on 5 landmarks on the palate (2 anterior, 2 posterior and 1 central). R3 used regions of interest around the 5 palatal landmarks used in R2. The differences between the registration methods were calculated by comparing the mean differences and standard deviations between the corresponding x, y and z coordinates of 6 corresponding landmarks in the T2 registered models. Repeated measures analysis of variance followed by post‐hoc Bonferroni tests were used for comparisons (P < .05). The agreement between methods and the intra and interobserver reproducibility were assessed with Bland‐Altman tests and intraclass correlation coefficients (ICC).ResultsComparisons of R2 with R3 methods showed greater agreement, mean differences ≤0.50 mm for all landmarks, than comparisons of R1 with R2, and R1 with R3, mean differences >0.50 mm for most of the y and z coordinates (P < .05). The R1 and R3 methods presented excellent intra and interobserver reproducibility and R2 method had moderate interobserver reproducibility.ConclusionsLongitudinal assessments of open bite treatment using digital dental models could consider the posterior teeth and/or the palate as references. The R1 and R3 methods showed adequate reproducibility and yield different quantitative results. The choice will depend on the posterior teeth changes and dental models’ characteristics.
Accuracy of MRI and X‐Ray Measurement of Displacement Distance of Humeral Lateral Condyle Fractures
Authors: Guo Lin , Li Xiaofeng , Wang Zhi , Zhu Shan 
Published: September 2021

ObjectiveTo investigate the accuracy of X‐ray and magnetic resonance imaging (MRI) measurements in evaluating the displacement of humeral lateral condyle fracture (HLCF) in different positions of the forearm based on human cadaveric HLCF models.MethodsThree human cadaveric elbow HLCF fracture models were successfully established. The wrist joint was fixed, and the forearm was rotated forward along the mid‐axis. The maximum distance between the two segments of the lateral fracture gap was defined as LFS (lateral fracture space) distance, and the maximum distance between the two segments of the fracture gap at the anterior and posterior margins of the fracture model was defined as PFS (posterior fracture space). The LFS and PFS distances of the human cadaveric elbow HLCF fracture models were measured during forearm rotation at 0º, 45º, 90º, and 135º rotation using a Capture Motion System (CMS), positive and lateral elbow X‐ray, coronal and sagittal MRI scans, respectively, and the CMS measurements were considered as the true fracture gap distances. The values obtained by CMS, X‐ray, and MRI measurements for both LPS and PFS distances in the HLCF fracture model at each position during rotation were recorded. The LFS and PFS distances were measured by two independent orthopaedic and joint imaging physicians. The data were measured three times by each physician, and the final values were the average of the two measurements. The outcomes were determined by whether a statistical difference exists in the LFS and PFS among the CMS, X‐ray, and MRI groups.ResultsThe interobserver agreement tests between the two observers showed good agreement in the measurements. A multiple sample ANOVA showed statistical differences in the LFS distances of HLCF measured at 0º, 45º, 90º, and 135º rotated by three radiographic measurements (P < 0.05). The LFS distances obtained by MRI and CMS measurements were greater than those obtained by X‐ray measurement in all positions using the LSD test (P < 0.05), and no statistical difference was found between the CMS and MRI methods in each position (P > 0.05). The same results were observed in terms of PFS values obtained by CMS, X‐ray, and MRI measurements at 0º, 45º, 90º, and 135º pronation. It was statistically different among the three groups as shown by multiple sample ANOVA (P < 0.05). The CMS and MRI measurements were greater than the X‐ray measurements (P < 0.05), while no statistical difference was observed between the CMS and MRI measurements (P > 0.05).ConclusionX‐rays often underestimate the degree of displacement of HLCF fractures; MRI measurements are closer to the true values compared with X‐ray.
Association between novel variants in BMPR1B gene and litter size in Mongolia and Ujimqin sheep breeds
Authors: Gao Yuanyuan , Hao Qi , Cang Ming , Wang Jianguo , Yu Haiquan , Liu Yongbin , Zhang Wenguang , Tong Bin 
Published: September 2021

AbstractProlificacy is an important trait of animals, specifically for sheep. The Bone morphogenetic protein receptor 1B (BMPR1B) is a major gene affecting the litter size of many sheep breeds. The well‐known FecB mutation (Q249R) was associated fully with the hyper prolific phenotype of Booroola Merino. However, the identification of variation in all exonic regions of BMPR1B was rare. In this study, we sequenced all exonic regions of BMPR1B gene of Mongolia sheep breed, and ten novel variants were detected by direct sequencing. Among them, the litter size of the Mongolia ewes with the CC genotype was significantly higher (0.34 additional lambs, p < .05) than those with the TT genotype of the g.29346567C>T single nucleotide polymorphism (SNP). The litter size of the Mongolia ewes with the TT genotype was significantly higher (0.19 additional lambs, p < .05 and .31 additional lambs, p < .01, respectively) than those with the GT and GG genotypes of the c.1470G>T SNP. The silent c.1470G>T mutation is predicted to increase the stability of the mRNA secondary structure through reducing minimum free energy and is predicted to change the mRNA secondary structure of BMPR1B. Our findings may give potentially useful genetic markers for increasing litter size in sheep.