bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of musculoskeletal pain and strenuous work on self-reported physical work ability: a cohort study of Swedish men and women
Authors: Badarin Kathryn , Hemmingsson Tomas , Hillert Lena , Kjellberg Katarina 
Published: November 2021

Abstract
Objective
We investigated the separate and combined effects of musculoskeletal pain (MSP) and strenuous work (heavy physical workload (PWL)/low-decision authority) on poor physical work ability (WA).

Methods
This study uses baseline data from the 2010 Stockholm Public Health Questionnaire (SPHQ) including 9419 workers with good physical WA. Exposure to PWL and decision authority were estimated using sex-specific job-exposure matrices linked to occupations. Exposures (high/low) were combined with the presence of MSP. Follow-up data on physical WA were taken from the 2014 SPHQ and dichotomised (the responses: “moderate”, “rather poor” and “very poor” indicated poor WA). Logistic regression models calculated sex-specific odds ratios adjusting for age, education and health and lifestyle factors. Interaction between MSP and strenuous work was examined using the synergy index (SI). Analyses were conducted using SPSS.27.

Results
MSP, heavy PWL and low-decision authority were separately associated with poor WA. MSP was associated with higher odds of poor WA than strenuous work for women, the opposite for men. Combinations of MSP and strenuous work often resulted in higher risks of poor WA than when adding the effects of the single exposures (e.g., MSP and heavy PWL men: AOR 4.04 95% CI 2.00–8.15, women: AOR: 3.25 95% CI 1.81–5.83). The SI was non-significant for both sexes.

Conclusion
Workers with MSP and strenuous work often had higher risks of poor WA than would be expected from adding the effects of the single exposures. To decrease poor WA in this group, strenuous work should be lowered, and MSP addressed in workplaces.
Inducing low energy availability in trained endurance male athletes results in poorer explosive power
Authors: Jurov Iva , Keay Nicola , Spudić Darjan , Rauter Samo 
Published: November 2021

Abstract
Purpose
Low energy availability in males needs more original research to understand its health and performance consequences. The aim of the study was to induce low energy availability in previously healthy male endurance athletes by reducing energy availability by 25% for 14 consecutive days and measure any potential changes in performance, health, mental state or energy markers.

Methods
Energy availability was reduced in 12 trained, well-trained and elite endurance athletes by increasing energy expenditure and controlling energy intake. After intervention, health was assessed by blood draw, body composition was measured, energy markers by measuring resting energy expenditure, performance with three specific tests (measuring endurance, agility and explosive power) and two questionnaires were used for psychological assessment (the Three Factor Eating Questionnaire and Well-being questionnaire).

Results
Reduced energy availability (22.4 ± 6.3 kcal/kg FFM/day) caused significantly lower haemoglobin values (t(12) = 2.652, p = 0.022), there was a tendency for lower iron and IGF-1 (p = 0.066 and p = 0.077, respectively). Explosive power was reduced (t(12) = 4.570, p = 0.001), lactate metabolism was altered and athletes reported poorer well-being (t(12) = 2.385, p = 0.036). Cognitive restriction was correlated with energy availability (r = 0.528, p = 0.039).

Conclusion
This is the first research providing direct evidence that suboptimal energy availability negatively impacts explosive power before hormonal changes occur in male endurance athletes. It is also the first to show direct association of low energy availability and higher cognitive restriction. We also observed worse well-being and lower haemoglobin values. 25% of energy availability reduction as not enough to elicit changes in resting energy expenditure.
Real-time analysis and predictability of the health functional food market using big data
Authors: Kim Sang-Soon , Lim Seokwon , Kim Sangoh 
Published: November 2021

AbstractThis study conducted a real-time analysis of the health functional food market using big data. To assess the scope of big data in market analysis, big data of the health food category were compared and analyzed with actual market data. Data were first collected using a program to obtain data, through application programming interfaces, followed by SPSS to compare and analyze the actual market index and shopping search word data. The correlation between the online search data and the actual market was high, indicating that online search data can be used to predict the trend of the actual market. Various types of data, such as items and major functional ingredients, can be collected and analyzed through the program developed for this study, which is also used to predict the market trend. The results demonstrate how APIs can be used to predict market size in the food industry effectively.
CAF promotes chemoresistance through NRP2 in gastric cancer
Authors: Yang Yanpeng , Ma Yongchen , Yan Shen , Wang Pengyuan , Hu Jianwen , Chen Shanwen , Zhu Jing , Wang Jingui , Chen Guowei , Liu Yucun 
Published: November 2021

Abstract
Background
Fibroblasts are the predominant cell type in the stroma of tumor, and cancer-associated fibroblasts (CAFs) promote cancer chemoresistance by secreting various bioactive molecules. However, the differential expression between CAFs and normal fibroblasts (NFs) and how can CAFs uniquely impact cancer cells are still unexplored.

Methods
Primary CAFs and NFs were cultured from gastric cancer specimens, and their variant expression was analyzed by RNA-sequencing. Chemoresistance was evaluated by measuring cell viability, apoptosis, and 3D-coculture techniques.

Results
CAFs were isolated from gastric cancers and defined by specific cell-surface markers. CAFs decreased the sensitivity of gastric cancer cells to 5-FU. RNA-sequencing showed that CAFs expressed a higher level of NRP2 than NFs. And the high expression of NRP2 was correlated with worse oncological outcomes in gastric cancer patients. Further study showed that the knockdown of NRP2 eradicated the resistance to 5-FU. And the secretion of stromal cell-derived factor-1 (SDF-1) was reduced following NRP2 knockdown. Furthermore, we found that the increased sensitivity to 5-FU was induced by DNA damage. And this process was mediated by predominant effectors of the Hippo pathway, YAP/TAZ.

Conclusions
The present study indicated that CAFs within gastric cancers promote chemoresistance through the expression of NRP2. The secretion of SDF-1 that mediated by VEGF/NRP2 signaling in CAFs and the activation of Hippo pathway in cancer cells in large part participated in this project.
Stability of Einstein metrics on symmetric spaces of compact type
Authors: Schwahn Paul 
Published: November 2021

AbstractWe prove the linear stability with respect to the Einstein-Hilbert action of the symmetric spaces$${\text {SU}}(n)$$SU(n),$$n\ge 3$$n≥3, and$$E_6/F_4$$E6/F4. Combined with earlier results, this resolves the stability problem for irreducible symmetric spaces of compact type.
Systematic risk in the biopharmaceutical sector: a multiscale approach
Authors: Uddin Gazi Salah , Yahya Muhammad , Bekiros Stelios , Jayasekera Raanadeva , Kling Gerhard 
Published: November 2021

AbstractIt is well documented that the biopharmaceutical sector has exhibited weak financial returns, contributing to underinvestment. Innovations in the industry carry high risks; however, an analysis of systematic risk and return compared to other asset classes is missing. This paper investigates the time–frequency interconnectedness between stocks in the biotech sector and ten asset classes using daily cross-country data from 1995 to 2019. We capture investors' heterogeneous investment horizons by decomposing time series according to frequencies. Using a maximal overlap discrete wavelet transform (MODWT) and a dynamic conditional correlation (DCC)-Student-t copula, diversification potentials are revealed, helping investors to reap the benefits of investing in biotech. Our findings indicate that the underlying assets exhibit nonlinear asymmetric behavior that strengthens during periods of turmoil.
One in five patients with Duchenne muscular dystrophy dies from other causes than cardiac or respiratory failure
Authors: Wahlgren Lisa , Kroksmark Anna-Karin , Tulinius Mar , Sofou Kalliopi 
Published: November 2021

AbstractDuchenne muscular dystrophy (DMD) is a severe neuromuscular disorder with increasing life expectancy from late teens to over 30 years of age. The aim of this nationwide study was to explore the prevalence, life expectancy and leading causes of death in patients with DMD in Sweden. Patients with DMD were identified through the National Quality Registry for Neuromuscular Diseases in Sweden, the Swedish Registry of Respiratory Failure, pathology laboratories, neurology and respiratory clinics, and the national network for neuromuscular diseases. Age and cause of death were retrieved from the Cause of Death Registry and cross-checked with medical records. 373 DMD patients born 1970–2019 were identified, of whom 129 patients deceased during the study period. Point prevalence of adult patients with DMD on December 31st 2019 was 3.2 per 100,000 adult males. Birth prevalence was 19.2 per 100,000 male births. Median survival was 29.9 years, the leading cause of death being cardiopulmonary in 79.9% of patients. Non-cardiopulmonary causes of death (20.1% of patients) mainly pertained to injury-related pulmonary embolism (1.3 per 1000 person-years), gastrointestinal complications (1.0 per 1000 person-years), stroke (0.6 per 1000 person-years) and unnatural deaths (1.6 per 1000 person-years). Death from non-cardiopulmonary causes occurred at younger ages (mean 21.0 years, SD 8.2; p = 0.004). Age at loss of independent ambulation did not have significant impact on overall survival (p = 0.26). We found that non-cardiopulmonary causes contribute to higher mortality among younger patients with DMD. We present novel epidemiological data on the increasing population of adult patients with DMD.
Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review
Authors: Dammacco Rosanna , Guerriero Silvana , Alessio Giovanni , Dammacco Franco 
Published: November 2021

AbstractPurposeTo provide an overview of the ocular features of rheumatoid arthritis (RA) and of the ophthalmic adverse drug reactions (ADRs) that may be associated with the administration of antirheumatic drugs.MethodsA systematic literature search was performed using the PubMed, MEDLINE, and EMBASE databases. In addition, a cohort of 489 RA patients who attended the Authors’ departments were examined.ResultsKeratoconjunctivitis sicca, episcleritis, scleritis, peripheral ulcerative keratitis (PUK), and anterior uveitis were diagnosed in 29%, 6%, 5%, 2%, and 10%, respectively, of the mentioned cohort. Ocular ADRs to non-steroidal anti-inflammatory drugs are rarely reported and include subconjunctival hemorrhages and hemorrhagic retinopathy. In patients taking indomethacin, whorl-like corneal deposits and pigmentary retinopathy have been observed. Glucocorticoids are frequently responsible for posterior subcapsular cataracts and open-angle glaucoma. Methotrexate, the prototype of disease-modifying antirheumatic drugs (DMARDs), has been associated with the onset of ischemic optic neuropathy, retinal cotton-wool spots, and orbital non-Hodgkin’s lymphoma. Mild cystoid macular edema and punctate keratitis in patients treated with leflunomide have been occasionally reported. The most frequently occurring ADR of hydroxychloroquine is vortex keratopathy, which may progress to “bull’s eye” maculopathy. Patients taking tofacitinib, a synthetic DMARD, more frequently suffer herpes zoster virus (HZV) reactivation, including ophthalmic HZ. Tumor necrosis factor inhibitors have been associated with the paradoxical onset or recurrence of uveitis or sarcoidosis, as well as optic neuritis, demyelinating optic neuropathy, chiasmopathy, and oculomotor palsy. Recurrent episodes of PUK, multiple cotton-wool spots, and retinal hemorrhages have occasionally been reported in patients given tocilizumab, that may also be associated with HZV reactivation, possibly involving the eye. Finally, rituximab, an anti-CD20 monoclonal antibody, has rarely been associated with necrotizing scleritis, macular edema, and visual impairment.ConclusionThe level of evidence for most of the drug reactions described herein is restricted to the “likely” or “possible” rather than to the “certain” category. However, the lack of biomarkers indicative of the potential risk of ocular ADRs hinders their prevention and emphasizes the need for an accurate risk vs. benefit assessment of these therapies for each patient.
Nonmonotonic Reasoning, Expectations Orderings, and Conceptual Spaces
Authors: Osta-Vélez Matías , Gärdenfors Peter 
Published: November 2021

AbstractIn Gärdenfors and Makinson (Artif Intell 65(2):197–245, 1994) and Gärdenfors (Knowledge representation and reasoning under uncertainty, Springer-Verlag, 1992) it was shown that it is possible to model nonmonotonic inference using a classical consequence relation plus an expectation-based ordering of formulas. In this article, we argue that this framework can be significantly enriched by adopting a conceptual spaces-based analysis of the role of expectations in reasoning. In particular, we show that this can solve various epistemological issues that surround nonmonotonic and default logics. We propose some formal criteria for constructing and updating expectation orderings based on conceptual spaces, and we explain how to apply them to nonmonotonic reasoning about objects and properties.
Development of 3H, 14C, 41Ca, 55Fe, 63Ni radiochemical analysis methods in activated concrete samples
Authors: Leskinen Anumaija , Salminen-Paatero Susanna 
Published: November 2021

AbstractDevelopment of 3H, 14C, 41Ca, 55Fe and 63Ni radiochemical analysis methods were carried out independently by two laboratories using both inactivate and activated concrete samples. Two preliminary radioanalytical procedures for the non-volatile radionuclides (41Ca, 55Fe, 63Ni) and one Thermal oxidation method for the volatile radionuclides (3H, 14C) were developed. The difficulties in the method development and analysis of results are discussed.
Atomism, Concepts, and Polysemy
Authors: Lemanek Kamil 
Published: November 2021

AbstractThe aim of this paper is to examine the theoretical architecture of semantic atomism and its consequences with respect to natural language. In particular, it looks to explore the notion of possible concepts using the fundamental distinction between simple and complex concepts and expressions in Jerry Fodor’s atomism. The distinction is exploited to produce an unusual type of concept referred to as a correlate, which effectively mirrors complex concepts while maintaining a distinct underlying structure. Though harmless in and of themselves, their presence in the context of polymorphemic expressions suggests that atomism harbors a tacit and unintuitive form of polysemy that is problematic in its own right and that leads to other complications, some of which may be demonstrated on the example of communication. These issues are tied to the way atomism is structured, and although they seem to have gone largely unnoticed, they appear to bear negatively on the adequacy of atomism where natural language is concerned.
Towards an Architecture of a Multi-purpose, User-Extendable Reference Human Brain Atlas
Authors: Nowinski Wieslaw L. 
Published: November 2021

AbstractHuman brain atlas development is predominantly research-oriented and the use of atlases in clinical practice is limited. Here I introduce a new definition of a reference human brain atlas that serves education, research and clinical applications, and is extendable by its user. Subsequently, an architecture of a multi-purpose, user-extendable reference human brain atlas is proposed and its implementation discussed. The human brain atlas is defined as a vehicle to gather, present, use, share, and discover knowledge about the human brain with highly organized content, tools enabling a wide range of its applications, massive and heterogeneous knowledge database, and means for content and knowledge growing by its users. The proposed architecture determines major components of the atlas, their mutual relationships, and functional roles. It contains four functional units, core cerebral models, knowledge database, research and clinical data input and conversion, and toolkit (supporting processing, content extension, atlas individualization, navigation, exploration, and display), all united by a user interface. Each unit is described in terms of its function, component modules and sub-modules, data handling, and implementation aspects. This novel architecture supports brain knowledge gathering, presentation, use, sharing, and discovery and is broadly applicable and useful in student- and educator-oriented neuroeducation for knowledge presentation and communication, research for knowledge acquisition, aggregation and discovery, and clinical applications in decision making support for prevention, diagnosis, treatment, monitoring, and prediction. It establishes a backbone for designing and developing new, multi-purpose and user-extendable brain atlas platforms, serving as a potential standard across labs, hospitals, and medical schools.
Biopharmaceutical Industry Capability Building in India: Report from a Symposium
Authors: Uppal Annu , Chakrabarti Ranjan , Chirmule Narendra , Rathore Anurag , Atouf Fouad 
Published: November 2021

AbstractThe biopharmaceutical industry is evolving with a shift in focus from recombinant proteins and antibodies towards more complex cell and gene therapies. To be competitive globally, biomanufacturers need to focus on aligning with global standards with regard to drug quality, reducing manufacturing failures and delivering drugs to market quickly. Building these capabilities requires a multifaceted approach that includes improvements in operations, quality compliance, and control strategies. To address these needs, the US Pharmacopeia (USP), the Department of Biotechnology (DBT) India, and the Confederation of Indian Industry (CII) held a symposium to discuss the requirements and gaps in the biotechnology and pharmaceutical sectors in India and other developing countries. A panel of experts from academia, manufacturing, and governmental agencies identified several drivers needed for capability building, including a skilled workforce, public–private partnerships, advanced manufacturing technologies, novel biologics, and favorable policies. This article summarizes the recommendations put forward by this panel.
Teaching scientific creativity through philosophy of science
Authors: Jaksland Rasmus 
Published: November 2021

AbstractThere is a demand to nurture scientific creativity in science education. This paper proposes that the relevant conceptual infrastructure with which to teach scientific creativity is often already included in philosophy of science courses, even those that do not cover scientific creativity explicitly. More precisely, it is shown how paradigm theory can serve as a framework with which to introduce the differences between combinational, exploratory, and transformational creativity in science. Moreover, the types of components given in Kuhn’s disciplinary matrix are argued to indicate a further subdivision within transformational creativity that makes explicit that this most radical type of creativity that aims to go beyond and thus to transform the current paradigm can take many different directions. More generally, it is argued that there are several synergies between the topic of scientific creativity and paradigm theory that can be utilized in most philosophy of science courses at relative ease. Doing so should promote the understanding of scientific creativity among students, provide another way to signify the relevance of paradigm theory, and more strategically be a way of reinforcing the place of philosophy of science in science education.
Fulvic acid isolation and characterisation from water of a Ramsar Lake Mansar, J&K, India
Authors: Sharma Arti , Anthal Ritika 
Published: November 2021

AbstractThe present study was undertaken with the aim to understand the chemical properties of aquatic fulvic acid in a clear water Lake Mansar. Along with that, the physical and chemical environment of the lake was also analysed. Fulvic acid was isolated from the water of Lake Mansar following IHSS recommended methodology and was subjected to characterisation, viz. elemental analysis, H-NMR and FTIR spectroscopy. The yield of fulvic acid from water of Lake Mansar was 0.22 mg/L that was far less than coloured aquatic systems. Elemental analysis revealed per cent carbon, hydrogen, nitrogen and oxygen content to be 53.6%, 5.04%, 6.3% and 35.06%, respectively. H-NMR and FTIR spectra revealed the presence of various functional groups like aliphatic, hydroxyl, amide, quinones, ketones, carbonyl, cellulose, etc. Based on the present studies, it was concluded that the origin of humic material in Lake Mansar is mostly from algae and non-vascular plants that have undergone less degree of humification.
The anisotropic mechanical characteristics of layered rocks under numerical simulation
Authors: Zhuo Xiao , Liu Xiangjun , Shi Xiangchao , Liang Lixi , Xiong Jian 
Published: November 2021

AbstractLayered rocks pose the challenge of wellbore stability in drilling engineering because of the anisotropic mechanical properties caused by the distinct weak planes. To understand the significant anisotropy of layered rocks in real formation condition, true triaxial compression tests are conducted by numerical simulation in this study. It is revealed that the mechanical responses of layered rocks are either controlled by the rock matrix or dominated by the weak plane and exhibit three different types associated with the orientations of the weak plane (including the dip direction α and dip angle β). When the orientations of the weak plane are α = 0°–90° and β = 0°, 60°–90°, the failure and strength properties of layered rocks depend entirely on the rock matrix, classified to the first type. Whereas the layered rocks with angle α ≤ 45° and β = 15°–45° fail by slipping failure along the weak plane, the relationship curves of rock strength versus the intermediate principal stress (σ2) are downward convex parabolas. In the last type, the mechanical behaviors of layered rocks with α > 45° and β = 15°–45°, involved in the changes of failure mode and the strength curve, are complex. Besides, the limitation of the simulation is discussed, and further studies on layered rocks are essential.
Validation of copula-based weather generator for maintenance model of offshore wind farm
Authors: Skobiej Bartosz , Niemi Arto 
Published: November 2021

AbstractThis article discusses the aspect of modeling weather conditions in marine environment for implementation in the offshore wind farm domain. It is clear that harsh sea weather conditions influence many characteristics of any offshore installation. The accessibility to the infrastructure, maintenance procedures, failure ratios of components, energy provision levels, or utilization of vessels—are the examples of weather-related issues connected to the offshore wind industry. Regarding the growing popularity of digital twin methodology, authors present a novel view to generate weather data with copula-based method. The results obtained are compared to selected historical data and implemented into the maintenance model. The selected indicators of maintenance service are used for usability assessment of proposed copula-based method.