bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of Dickkopf-1 as a biomarker in systemic lupus erythematosus and active lupus nephritis
Authors: Abdelazeem Mervat E. , Abdelhaleem Marwa I. , Mohamed Rabab A. , Abdelaleem Enas A. 
Published: March 2021

Abstract
Background
Systemic lupus erythematosus (SLE) is a chronic disease which is mainly attributed to autoantibodies, cytokines, and immune complex deposition. Studies have demonstrated that cytokines and autoantibodies were strongly associated with renal diseases and can be used for the prediction of patients with lupus nephritis (LN). However, antibodies to dsDNA and the reduction of complements were also detected in non-LN patients as well as clinically non-active SLE patients. The current study was performed to detect the role of serum DKK-1 as a biomarker for the identification of SLE patients and patients with LN and its relation to disease activity and severity. The study was conducted on fifty clinically diagnosed SLE patients who were diagnosed according to Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for SLE, in addition to thirty healthy control volunteers matched for age and sex. Assessment of SLE disease activity was done using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Assessment of SLE disease severity was done using the Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) damage index. Serum levels of DKK-1 were measured for all participants by ELISA using commercially available kits.

Results
DKK-1 serum levels were significantly higher among active lupus nephritis cases as compared with SLE cases with no LN and with healthy controls (9197.60 μg/uL ± 2939.2 μg/uL vs. 6405.15 μg/uL ± 2018.91 μg/uL vs. 2790.33 μg/uL ± 833.49 μg/uL) respectively (p-values < 0.001). DKK-1 concentration was significantly higher among SLE patients with positive as compared with negative anti-double-stranded DNA (dsDNA) antibodies (p-value < 0.001). According to receiver operating characteristic (ROC) curve analysis, serum DKK-1 level diagnosed the SLE at a statistically significant level with a 98% sensitivity and 70% specificity and serum DKK-1 level also diagnosed active lupus nephritis at a 90% sensitivity and 63% specificity.

Conclusion
DKK-1 could diagnose SLE and lupus nephritis with high sensitivity and specificity. Serum DKK-1 is a reliable biomarker for the identification of SLE and patients with LN and could be used as a key molecule for the diagnosis of SLE and as a prognostic indicator of LN.
The effects of lactic acid bacteria and yeasts as probiotics on the growth performance, relative organ weight, blood parameters, and immune responses of broiler: A meta-analysis
Authors: Sjofjan Osfar , Adli Danung Nur , Harahap Rakhmad Perkasa , Jayanegara Anuraga , Utama Dicky Tri , Seruni Ainun Pizar 
Published: March 2021

Introduction: The number of publications in Scopus on this topic increased from less than 50 in 1995 to more than 250 in 2015. In other hand, Inconsistency in results about the correlation between yeast and lactic acid bacteria as probiotics has been evident since the early publications on use in broilers. Methods: A meta-analysis was conducted to determine relationship between lactic acid bacteria and yeast as probiotics to broiler diets on the growth performance, relative organ weight, blood parameters, and immune response of the broiler. A database was designed based on published data that reported the use of probiotics on the broiler. The method used for selecting articles was based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) method. Articles selected were taken from PubMed, Web of science, Scopus, Google Scholar, and Science direct databases as well as individual. Results: The final database consists of 49 in vivo articles, 93 studies, and 225 treatments. The analysis statement in the system was a PROC MIXED procedure of SAS software. The level of probiotic increased (p <0.001) body weight, body weight gain, and feed intake of broiler. There was a reduction (p <0.01) on feed conversion ratio and mortality on the level probiotic given to broiler. Supplementation of probiotics in broiler diet increased (p <0.001) the weight of liver, spleen, gizzard, bursa of fabricius and carcass yield, while reduced (p<0.001) abdominal fat weight. The probiotic given increased the total of red and white blood cells (both at p < 0.001) but did not affect lymphocyte. Discussion: It can be concluded the yeast act as supporting agent that serves lactic acid bacteria as probiotic increases the growth performance, relative organ weight, blood parameters, and immune response of the broiler.
Prognostic significance of estrogen, progesterone and HER2 receptors’ status conversion following neoadjuvant chemotherapy in patients with locally advanced breast cancer: Results from a tertiary Cancer Center in Saudi Arabia
Authors: Al-Saleh Khalid , Salah Tareq , Arafah Maria , Husain Sufia , Al-Rikabi Ammar , Abd El-Aziz Nashwa 
Published: March 2021

Background
The prognostic impact of neoadjuvant chemotherapy (NAC) on the receptor expression status in patients with locally advanced breast cancer (LABC) is still not fully understood. We aimed to evaluate the changes in hormone (estrogen and progesterone) receptor (HR) and human epidermal growth factor receptor 2 (HER2) status post-NAC and their correlation with survival.

Methods
Patients with LABC who have received NAC between 2008 and 2015 and have been followed up till December 2019 at the Oncology Center, King Saud University, KSA were analyzed retrospectively. biomarker analysis of ER, PR & HER2 were done using immunohistochemistry (IHC) and Fluorescent in situ hybridization.

Results
Ninety-one patients fulfilled the inclusion criteria. HR status changed in 21(23.1%) patients, with a significant difference between patients with stable receptors and those with any receptor conversion; p = 0.000. Five (5.5%) initially HER2 negative tumors became HER2 positive and 10 (11%) initially HER2 positive tumors became HER2 negative after NAC. The difference in HER2 expression level before and after NAC was not statistically significant (p = 0.302). Univariate analysis relating patients’ characteristics and 10-years disease-free survival (DFS) showed only significant correlations with the expressions of ER, PR, and any receptor conversion, (ER and/or PR) p< 0.001, p< 0.001, and p = 0.001; respectively. In the univariate analysis, none of the clinicopathological features showed a significant correlation with the OS except for the molecular subtypes P<0.001.

Conclusions
Patients with LABC have significant changes in the ER and PR receptor status following NAC. Post-NAC expressions change of ER and PR (ER and/or PR) are correlated to DFS. Retesting of the hormone receptors should be considered after NAC in Saudi patients with LABC.
Effects of GABA/β-glucan supplements on melatonin and serotonin content extracted from natural resources
Authors: Dutta Sayan Deb , Patel Dinesh K. , Ganguly Keya , Lim Ki-Taek 
Published: March 2021

Objective
This study aimed to monitor the secretion of serotonin and melatonin in the blood serum of rats in the presence of rice bran (RB), and Sarcodon aspratus (S) extracts for sleep promotion.

Background
Sleep is a natural physiological phenomenon, and sleep disorders may cause severe mental hazards leading to excessive daytime sleepiness (EDS). The γ-aminobutyric acid (GABA) and β-glucan are the essential active ingredients of RB and mushroom, respectively, exhibited stress-reduction and nerve stabilizing potential through regulation of melatonin and serotonin hormones.

Methods
Cytotoxicity of the extracts (RBS) was evaluated through WST-1 assay. The melatonin and serotonin concentrations in the blood serum were measured through ELISA kits. The Ig ELISA kit measured the immunoglobulin’s (IgG, IgM, and IgA) concentrations.

Results
Improved cell viability was observed in RBS treated groups than control, indicating their biocompatibility. The melatonin and serotonin levels were high in RBS (5:5 and 7:3) treated groups compared to the control. Enhanced expression of immunoglobulin (Ig) A and G level was observed in RBS treated rats. The serotonergic genes (5-HTT, 5-HT 1B, and MAO-A) expression levels were upregulated in RBS treated groups vis-à-vis the control.

Conclusion
Based on these results, we anticipated that RBS supplements could promote the sleep phenomenon by elevating the serotonin/melatonin level in the blood through the serotonergic system. Therefore, RBS supplements can be utilized as functional food material for sleep promotion.
Money in Economic Activity and Language of the Old Believers of the South America
Authors: Rovnova Olga 
Published: March 2021

The article investigates how lexemes within the lexical field “Money” are used in the Russian dialects of Old Believers spoken in Argentina, Bolivia, Brazil and Uruguay. The study addresses the use of recently borrowed names for monetary units as well as of the original Russian nouns. The dialectal material is compared with the data from the Dictionary of Contemporary Russian Colloquial Language and from a variety of dialectal dictionaries. Special attention is given to the names for Russian monetary units rublʹ and kopejka. The word kopejka has retained some of the original Russian figurative meanings and developed a new one. The fact that kopejka has not fallen into disuse in the figurative meaning is not surprising given that original Russian idioms are very well preserved in the dialects in question, including those with kopejka (the latter are analysed in the article). The study has demonstrated significant similarity between the Old Believers’ dialects in South America and Russian varieties spoken in Russia with respect to the semantic field “Money”. At the same time, the analysis has revealed several properties which are unique to the Old Believers’ dialects. These include deviations in lexical meaning, in collocational and stylistic properties, and in usage.
Sampul Depan
Authors: Nurhayati Ai 
Published: March 2021

Puji dan syukur kami panjatkan ke Hadirat Allah SWT, karena berkat Rahmat dan Hidayah-Nya kami dapat menerbitkan jurnal di bidang pendidikan, gizi, dan kuliner Tata Boga. Jurnal ini disusun sebagai wujud usaha program studi pendidikan tata boga untuk mempublikasikan karya ilmiah mahasiswa maupun dosen di bidang pendidikan, gizi, dan kuliner Tata Boga secara online. Usaha ini dilakukan berdasarkan pada surat edaran dari Dirjen DIKTI No. 2050/E/T/2011 tentang kebijakan unggah karya ilmiah dan jurnal. Kebijakan tersebut kemudian direalisasikan oleh UPI melalui kebijakan dalam bentuk program pengembangan jurnal setiap departemen dan program studi di lingkungan UPI.Jurnal ini diberi nama Media Pendidikan, Gizi, dan Kuliner. Jurnal ini akan terbit secara berkala dua kali dalam setahun, yaitu setiap bulan November dan April. Pada bulan April 2019 ini merupakan jurnal terbitan volume kedelapan dan nomor satu.Kami mengucapkan banyak terima kasih kepada semua pihak yang telah membantu terbitnya jurnal ini. Selain itu, kami pun mengucapkan terima kasih kepada para kontributor yang telah mengirimkan naskah artikel hasil penelitiannya. Semoga jurnal ini dapat terus terbit secara berkala dan memberikan sumbangan pada dunia keilmuan dan perkembangan teknologi di Indonesia.
ANALISIS KESULITAN BELAJAR STATISTIKA MAHASISWA PENDIDIKAN TATA BOGA
Authors: Nurdianto Win Berkat , Juwaedah Ade , Karpin Karpin 
Published: March 2021

ABSTRAKKesulitan belajar merupakan gejala dimana individu tidak bisa belajar sebagaimana mestinya, hal ini bisa disebabkan oleh materi pembelajaran yang sulit serta faktor internal dan eksternal individu itu sendiri. Kesulitan belajar ini diduga dialami oleh mahasiswa Program Studi Pendidikan Tata Boga pada mata kuliah statistika. Penelitian ini bertujuan untuk mengetahui materi mengenai pengertian istilah dasar statistika dan materi statistika dalam bentuk kasus yang dianggap sulit serta faktor internal penyebab kesulitan belajar statistika. Penelitian ini menggunakan metode deskriptif kuantitatif. Populasi penelitian adalah mahasiswa Prodi Pendidikan Tata Boga angkatan tahun 2017 dengan jumlah 44 orang. Dari hasil penelitian ditemukan bahwa pada materi pengertian istilah dasar statistika mahasiswa Prodi Pendidikan Tata Boga angkatan 2017 mengalami kesulitan belajar dengan kategori sangat sulit yaitu pada materi analisis regresi dan kurtosis, dan kategori sulit yaitu pada materi ukuran kemiringan, hipotesis dan analisis korelasi. Pada materi bentuk kasus mengalami kesulitan belajar dengan kategori sangat sulit pada materi ukuran kemiringan, kurtosis dan analisis regresi, pada materi dengan kategori sulit yaitu ukuran dispersi, hipotesis dan analisis korelasi, sedangkan kategori materi cukup sulit yaitu pada materi penyajian data dan ukuran letak. Faktor internal yang menyebabkan kesulitan belajar dengan kategori besar penyebabnya yaitu kebiasaan belajar, dan faktor internal penyebab kesulitan belajar dengan kategori cukup besar adalah minat belajar, motivasi belajar dan kemampuan belajar. Mahasiswa mengalami kesulitan belajar pada materi statistika pengertian dasar dan materi bentuk kasus dimana disebabkan empat faktor internal. Rekomendasi dari hasil penelitian ini yaitu memperbaiki intensitas dan cara belajar dengan memperbaiki aspek internal untuk memaksimalkan pemahaman serta hasil belajar statistika.
Associated Risk Factors for Bacterial Urinary Tract Infection among Internally Displaced Pregnant Women in Niger Delta Camps, Nigeria
Authors: Diorgu Faith , Ehianu Maynard , Francis Anacletus 
Published: March 2021

Associated Risk Factors for Bacterial Urinary Tract Infection among Internally Displaced Pregnant Women in Niger Delta Camps, Nigeria

Abstract
This study investigated associated risk factors for bacterial urinary tract infection among internally displaced pregnant women in Niger Delta camps. The objectives of the study were to determine the association between age, parity, trimester of pregnancy, religion and the incidence of bacterial urinary tract infection among internally displaced pregnant women. The population of the study comprised 108 internally displaced pregnant women who also formed the study sample as no sampling method was adopted due to the limited number of study participants. The tools for data collection was midstream urine samples collected using sterile screw-capped universal containers, the instruments used in isolating the bacterial uropathogens, include Cysteine-Lactose Deficient (CLED) agar, MacConkey and Nutrient agar plates as well as a structured checklist in socio-demographic characteristics of the pregnant women. Descriptive statistics of frequency and percentage were used for data analysis and the Statistical Package for Social Sciences (SPSS) software was employed in the analytical process. Results from the study showed there was no significant association between age, parity, trimester of pregnancy, and the incidence of bacterial urinary tract infection among internally displaced pregnant women (P>0.05). However, religion was significantly associated with the incidence of bacterial urinary tract infection among internally displaced pregnant women (P<0.05). The study concluded that there is an increasing incidence of bacterial urinary tract infections among internally displaced pregnant women linked to religious beliefs. Based on the study findings, early routine screening of all internally pregnant women presenting or not presenting with clinical symptoms of urinary tract infection is recommended. The need for good personal and environmental hygiene to be encouraged in internally displaced persons’ camps.
Keywords: Associated risk factors, Bacterial urinary tract infection, Internally Displaced Women, Camps, Niger Delta
Functional product – squash and melon jam
Authors: Gulin A. V. , Pavlov L. V. , Sannikova T. A. , Machulkina V. A. 
Published: March 2021

Relevance. Providing the population with functional, environmentally friendly and high-quality food is an urgent scientific and state problem. With prolonged use of contaminated products, the risk of various diseases increases. Therefore, the human diet should consist of functional, environmentally friendly products. The main goal of this research work was the production of high-quality jam from environmentally friendly raw materials of plant origin.Methods. For the preparation of the jam, the fruits of the Sosnovsky zucchini variety and the Lada melon of the technical and biological degree of maturity were used. The technological process of making jam took place in accordance with the technological requirements for this type of product. The content of biochemical parameters: dry matter, the amount of sugars, pectin and nitrates) were determined in fresh and finished (after the fermentation period) products.Results. Jam with a melon aroma was obtained with a glucose content of 4.5-6.73%, fructose - 4.66-7.17% with an accumulation of nitrates in the range of 127.1 mg / kg (fruits of biological maturity) and 131.6 mg / kg (fruits of technical maturity), which is 3.0-3.1 times lower than the maximum permissible concentration. The tasting committee rated the jam made from fruits of technical maturity at 4.3 points, and biological at 4.8 points. Thus, summarizing the results of our research, we can conclude that the jam made from zucchini fruits with the addition of melon is a functional, high-vitamin, environmentally friendly food product with high taste.
Nowy system warunkowości w prawie Unii Europejskiej
Authors: Gontarski Waldemar 
Published: March 2021

Autor omawia zgodność z prawem traktatowym projektowanego systemu warunkowości, dotyczącego zawieszania wypłaty funduszy unijnych państwom członkowskim w związku z zarzutem naruszania praworządności i innych zasad ogólnych. Tak rozumiana nowa warunkowość rozpatrzona została w kontekście dotychczasowego uzależniania wydatkowania funduszy unijnych (a wcześniej wspólnotowych) od spełnienia określonych kryteriów jako utrwalonej praktyki zarządzania funduszami.
Celem niniejszego opracowania jest zbadanie zgodności z prawem traktatowym nowego systemu warunkowości dotyczącego ochrony praworządności i innych zasad ogólnych postulowanego w konkluzjach Rady Europejskiej z 17–21.07.2020 r. jako kontynuacji prac nad projektowanym przez Komisję rozporządzeniem Parlamentu Europejskiego i Rady w sprawie ochrony budżetu Unii w przypadku uogólnionych braków w zakresie praworządności w państwach członkowskich z 2.05.2018 r.
CARACTERÍSTICAS CLÍNICAS, FÍSICO-FUNCIONAIS E LABORATORIAIS DE IDOSOS COM ALTO E BAIXO RISCO DE QUEDAS
Authors: Costa Andreia Cristina Travassos da , Moura Ribeiro Emerson , Avelino Rodrigues Claudio , Tiane Joodsie Costa da Silva Sarah , Sinésio Silva Neto Luiz , Barbosa Osório Neila 
Published: March 2021

O envelhecimento favorece algumas mudanças no corpo, o que agrava o estado de saúde e gera riscos de quedas, por isso torna-se importante o estudo das características de idosos com maior risco de quedas. Este estudo procurou comparar as características clínicas, físico-funcionais e laboratoriais de idosos com baixo e alto risco de quedas, classificados pelo teste de Timed up and Go (TUG). Trata-se de um estudo transversal com amostra de conveniência, realizado na Universidade de Maturidade da Universidade Federal do Tocantins. Participaram do estudo 40 idosos que foram submetidos à avaliação da composição corporal, flexibilidade, força de preensão palmar, velocidade de caminhada e exames laboratoriais. Um ponto de corte de 12,47s no teste TUG classificou os idosos em alto risco de quedas (ARQ) e baixo risco de quedas (BRQ), sendo que, 70% dos idosos foram classificados como BRQ e 30% como ARQ. Os idosos com ARQ são mais velhos, possuem maior gordura corporal e uso de polifarmácia (63%), além de baixa flexibilidade, funcionalidade e força muscular.
Gallbladder Adenosquamous Cancer With Situs Inversus Totalis: A Case Report and Literature Review
Authors: Huang JunMing , Yang Hanjin , Wang Meng , Zhao Xinyu , Shao Shiyi , Zhang Fu , Que Risheng , Hu Qida , Liang Tingbo 
Published: March 2021

Abstract
Background: Situs inversus totalis (SIT) is a rare genetic congenital disease, characterized by complete right-left inversion of all the internal organs. We herein describe a meaningful case which was diagnosed as gallbladder adenosquamous carcinoma, a rare histology type of gallbladder cancer, with SIT. Case presrntaton: A 59-year-old Chinese woman was admitted for persistent epigastric distention and intermittent abdominal pain. The abdominal CT scan revealed a huge mass at the gallbladder bottom, involving the adjacent transverse colon and liver. En-bloc radical resection of the gallbladder cancer, including partial colonectomy and hepatectomy with regional node dissection, followed by colocolostomy and Roux-en-Y choledochojejunostomy, was successfully performed Pathology analysis indicated an adenosquamous carcinoma with positive adenocarcinoma marker (CK7, CK19) and squamous carcinoma markers (CK5/6, P63). Conclusion: The SIT anomaly might increase the risk of malignancies by sharing genome mutations, suggesting the importance of surveillance in the SIT settings.
Histopathology and Clinical Implication of Treatment-related Image Changes After Surgical Resection of Brain Metastases Previously Treated with Gamma Knife Radiosurgery
Authors: Kim Jeong-Hwa , Lee Jung-Il , Choi Jung-Won , Kong Doo-Sik , Seol Ho-Jun , Nam Do-Hyun 
Published: March 2021

Abstract
INTRODUCTION The true pathology and clinical implication of treatment-related image changes (TRICs) after stereotactic radiosurgery (SRS) for brain metastases (BM) have not been established. This study compared the surgical pathology and outcomes of intracranial metastatic lesions featured as TRICs or progressive disease (PD) in advanced magnetic resonance imaging (MRI).METHODS A total of 86 patients who underwent surgical resection of brain metastases previously treated with gamma knife radiosurgery (GKS) from 2009 to 2019 were retrospectively reviewed and classified by MRI findings and histopathology.RESULTS Among 54 patients with TRICs in preoperative MRI, the histopathology of pure radiation necrosis (RN) was confirmed in 19 patients (TRIC-RN) and mixed or predominant viable tumor cells in 35 patients (TRIC-PD). Thirty-two patients diagnosed with PD exhibited the metastatic histology well correlated with imaging (PD-PD). The TRIC-PD group showed larger prescription isodose volume (9.4 cm3) than the TRIC-RN (4.06 cm3, p=0.014) group and shorter time interval from GKS to preoperative MRI diagnosis related to neurological deficits (median 4.07 months) than the PD-PD group (median 8.77 months, p=0.004). Significant differences in progression-free survival were confirmed among the three groups (p<0.001) but not between TRIC-RN and TRIC-PD (post hoc test, p=1.00), whereas no significant difference was observed in overall survival (p=0.067). CONCLUSIONS The brain metastatic lesions diagnosed as TRICs after GKS frequently contained viable tumor cells, while they exhibited the benign prognosis as RN after surgical resection. These findings suggest that TRICs on advanced MRI can serve as a prognostic factor, regardless of the histologic heterogeneity.