bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydronephrosis Classifications: Has UTD Overtaken APD and SFU? A Worldwide Survey
Authors: Vallasciani Santiago , Bujons Tur Anna , Gatti John , Machado Marcos , Cooper Christopher S. , Farrugia Marie Klaire , Zhou Huixia , El Anbari Mohammed , Lopez Pedro-José 
Published: April 2021

Objective: To collect baseline information on the ultrasonographic reporting preferences.Method: A 13-multiple choice questionnaire was designed and distributed worldwide among pediatric urologists, pediatric surgeons, and urologists. The statistical analysis of the survey data consisted of 3 steps: a univariate analysis, a bivariate and a multivariate analysis.Results: Three hundred eighty participants responded from all the continents. The bivariate analysis showed the significant differences in the geographical area, the years of experience and the volume of cases. Most of the physicians prefer the SFU and APD systems because of familiarity and simplicity (37 and 34%, respectively). Respondents noted that their imaging providers most often report findings utilizing the mild-moderate-severe system or the APD measurements (28 and 39%, respectively) except for North America (SFU in 50%). Multivariate analysis did not provide significant differences.Conclusion: Our study evaluates the opinions regarding the various pediatric hydronephrosis classification systems from a large number of specialists and demonstrates that there is no single preferred grading system. The greatest reported shortcoming of all the systems was the lack of universal utilization. The observations taken from this study may serve as basis for the construction of a common worldwide system. As APD and SFU are the preferred systems and the UTD a newer combination of both, it is possible that with time, UTD may become the universal language for reporting hydronephrosis. This time, based on the result of this survey, seems not arrived yet.
The Cardioprotective Mechanism of Phenylaminoethyl Selenides (PAESe) Against Doxorubicin-Induced Cardiotoxicity Involves Frataxin
Authors: Fu Xiaoyu , Eggert Mathew , Yoo Sieun , Patel Nikhil , Zhong Juming , Steinke Ian , Govindarajulu Manoj , Turumtay Emine Akyuz , Mouli Shravanthi , Panizzi Peter , Beyers Ronald , Denney Thomas , Arnold Robert , Amin Rajesh H. 
Published: April 2021

Doxorubicin (DOX) is an anthracycline cancer chemotherapeutic that exhibits cumulative dose-limiting cardiotoxicity and limits its clinical utility. DOX treatment results in the development of morbid cardiac hypertrophy that progresses to congestive heart failure and death. Recent evidence suggests that during the development of DOX mediated cardiac hypertrophy, mitochondrial energetics are severely compromised, thus priming the cardiomyocyte for failure. To mitigate cumulative dose (5 mg/kg, QIW x 4 weeks with 2 weeks recovery) dependent DOX, mediated cardiac hypertrophy, we applied an orally active selenium based compound termed phenylaminoethyl selenides (PAESe) (QIW 10 mg/kg x 5) to our animal model and observed that PAESe attenuates DOX-mediated cardiac hypertrophy in athymic mice, as observed by MRI analysis. Mechanistically, we demonstrated that DOX impedes the stability of the iron-sulfur cluster biogenesis protein Frataxin (FXN) (0.5 fold), resulting in enhanced mitochondrial free iron accumulation (2.5 fold) and reduced aconitase activity (0.4 fold). Our findings further indicate that PAESe prevented the reduction of FXN levels and the ensuing elevation of mitochondrial free iron levels. PAESe has been shown to have anti-oxidative properties in part, by regeneration of glutathione levels. Therefore, we observed that PAESe can mitigate DOX mediated cardiac hypertrophy by enhancing glutathione activity (0.4 fold) and inhibiting ROS formation (1.8 fold). Lastly, we observed that DOX significantly reduced cellular respiration (basal (5%) and uncoupled (10%)) in H9C2 cardiomyoblasts and that PAESe protects against the DOX-mediated attenuation of cellular respiration. In conclusion, the current study determined the protective mechanism of PAESe against DOX mediated myocardial damage and that FXN is implicitly involved in DOX-mediated cardiotoxicity.
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos
Authors: Varela Nelson M. , Guevara-Ramírez Patricia , Acevedo Cristian , Zambrano Tomás , Armendáriz-Castillo Isaac , Guerrero Santiago , Quiñones Luis A. , López-Cortés Andrés 
Published: April 2021

Background: Breast cancer (BRCA) and prostate cancer (PRCA) are the most commonly diagnosed cancer types in Latin American women and men, respectively. Although in recent years large-scale efforts from international consortia have focused on improving precision oncology, a better understanding of genomic features of BRCA and PRCA in developing regions and racial/ethnic minority populations is still required.Methods: To fill in this gap, we performed integrated in silico analyses to elucidate oncogenic variants from BRCA and PRCA driver genes; to calculate their deleteriousness scores and allele frequencies from seven human populations worldwide, including Latinos; and to propose the most effective therapeutic strategies based on precision oncology.Results: We analyzed 339,100 variants belonging to 99 BRCA and 82 PRCA driver genes and identified 18,512 and 15,648 known/predicted oncogenic variants, respectively. Regarding known oncogenic variants, we prioritized the most frequent and deleterious variants of BRCA (n = 230) and PRCA (n = 167) from Latino, African, Ashkenazi Jewish, East Asian, South Asian, European Finnish, and European non-Finnish populations, to incorporate them into pharmacogenomics testing. Lastly, we identified which oncogenic variants may shape the response to anti-cancer therapies, detailing the current status of pharmacogenomics guidelines and clinical trials involved in BRCA and PRCA cancer driver proteins.Conclusion: It is imperative to unify efforts where developing countries might invest in obtaining databases of genomic profiles of their populations, and developed countries might incorporate racial/ethnic minority populations in future clinical trials and cancer researches with the overall objective of fomenting pharmacogenomics in clinical practice and public health policies.
Fear of Cancer Recurrence, Health Anxiety, Worry, and Uncertainty: A Scoping Review About Their Conceptualization and Measurement Within Breast Cancer Survivorship Research
Authors: Maheu Christine , Singh Mina , Tock Wing Lam , Eyrenci Asli , Galica Jacqueline , Hébert Maude , Frati Francesca , Estapé Tania 
Published: April 2021

Objective:Fear of Cancer Recurrence (FCR), Health Anxiety (HA), worry, and uncertainty in illness are psychological concerns commonly faced by cancer patients. In survivorship research, these similar, yet different constructs are frequently used interchangeably and multiple instruments are used in to measure them. The lack of clear and consistent conceptualization and measurement can lead to diverse or contradictory interpretations. The purpose of this scoping review was to review, compare, and analyze the current conceptualization and measurements used for FCR, HA, worry, and uncertainty in the breast cancer survivorship literature to improve research and practice.Inclusion Criteria:We considered quantitative, qualitative, and mixed methods studies of breast cancer survivors that examined FCR, HA, worry, or uncertainty in illness as a main topic and included a definition or assessment of the constructs.Methods and Analysis:The six-staged framework was used to guide the scoping review process. Searches of PubMed, CINAHL, and PsycINFO databases were conducted. The principle-based qualitative analysis and simultaneous content analysis procedures were employed to synthesize and map the findings.Findings:After duplicate removal, the search revealed 3,299 articles, of which 82 studies met the inclusion criteria. Several critical attributes overlapped the four constructs, for example, all were triggered by internal somatic and external cues. However, several unique attributes were found (e.g., a sense of loss of security in the body is observed only among survivors experiencing FCR). Overall, findings showed that FCR and uncertainty in illness are more likely to be triggered by cancer-specific factors, while worry and HA have more trait-like in terms of characteristics, theoretical features, and correlates. We found that the measures used to assess each construct were on par with their intended constructs. Eighteen approaches were used to measure FCR, 15 for HA, 8 for worry, and 4 for uncertainty.Conclusion:While consensus on the conceptualization and measurement of the four constructs has not yet been reached, this scoping review identifies key similarities and differences to aid in their selection and measurement. Considering the observed overlap between the four studied constructs, further research delineating the unique attributes for each construct is warranted.
Dependence of the interfacial atomic structure of SiO2/GaN upon SiO2 deposition methods and post-deposition annealing, as revealed by X-ray absorption spectroscopy
Authors: Isomura Noritake , Soejima Narumasa , Mori Tomohiko , Ikeda Satoshi , Watanabe Atsushi , Okawa Takashi , Tomita Hidemoto 
Published: April 2021

Abstract
The interface between a gate insulator (SiO2) and a semiconductor (GaN), which can affect the performance of a power device, was investigated via X-ray absorption spectroscopy and X-ray photoelectron spectroscopy. Experiments were performed to sensitively detect the interface with analytical depth. In atomic layer deposition of SiO2, Ga oxide was formed at the interface during the formation of SiO2 film. However, in plasma-enhanced chemical vapor deposition, this formation was not observed, and the crystallinity of the GaN-side interface was improved via post-deposition annealing.
Nanometer-scale ordered arrangement of diamond nanoparticles on substrates via electrostatic deposition
Authors: Yoshikawa Taro , Liu Ming , Miyake Hiroto , Ieki Ryosuke , Kojima Ryouta , Makino Yuto , Tsurui Akihiko , Mahiko Tomoaki , Nishikawa Masahiro 
Published: April 2021

Abstract
We demonstrate a nanometer-scale ordered arrangement of diamond nanoparticles (DNPs) on SiO2 surfaces via the technique of electrostatic deposition. Using the lift-off process combining electron beam lithography and surface functionalization with 3-aminopropyltriethoxysilane, the negative zeta potential of SiO2 surfaces are locally inversed to positive. Consequently, the DNPs are deposited on the limited SiO2 surface areas with ≥100 nm pitch line-and-space and dot array patterns where the electrostatic attractive interaction works. Since this approach does not rely on any specific material property other than zeta potential, it would be applicable to any material combination of charged nanoparticles and substrates.
Hallazgos tomográficos en pacientes con COVID-19
Authors: Villeda Bojorque Samuel , López Elvis I. , Villeda Samuel , Echeverría José C , Cotí-de-Xicará Mary 
Published: April 2021

Introducción: debido al incremento constante de infección por SARS Cov2, es fundamental conocer los hallazgos radiológicos de esta enfermedad, ya que ésta juega un papel muy importante en el abordaje y manejo de estos pacientes. Objetivo: establecer los principales hallazgos radiológicos en tomografía torácica (TT) de pacientes con diagnóstico de infección por SARS Cov2, que acudieron a un centro diagnóstico de Quetzaltenango, Guatemala. Material y métodos: hallazgos en TT en pacientes con prueba positiva de RT-PCR para SARS Cov2, de pacientes que acudieron a un centro de diagnóstico por Imágenes en Quetzaltenango, de marzo a agosto de 2020. Resultados: de las 82 TT analizadas, 56% fueron de pacientes masculinos. El grupo etario más prevalente fue de 41-50 años (27%). El patrón tomográfico predominante fue imagen en vidrio despulido (41%); la localización más frecuente fue bilateral (90%); el lóbulo pulmonar más frecuentemente afectado fue el lóbulo inferior (71%). Discusión: En general, nuestros hallazgos fueron similares a los previamente reportados.
Clústeres universitarios: ¿estrategia eficaz para el fomento del espíritu emprendedor en los alumnos de pregrado? / University clusters: effective strategy for enhancing entrepreneurship spirit in undergraduate students?
Authors: Garza Roche Regina , Barroso Tanoira Francisco Gerardo , Canul Homá Edgar Román , Rivera Cuellar Carola H. , Carrillo Cervera Ángel , Guedimin Bojórquez Delfina María , Belain Rivas Tabata 
Published: April 2021

El presente trabajo identifica las estrategias que emplean diversas instituciones de educación superior para fomentar el espíritu emprendedor en sus estudiantes de pregrado, así como el involucramiento de diferentes actores de la sociedad, a través de la formación de clústeres universitarios que permitan resultados de alto impacto en emprendimiento, innovación y solución a problemas sociales. Esto es posible a través de la formación de recursos humanos, pensamiento disruptivo, generación de conocimiento y vinculación con los sectores productivo, académico y gubernamental. Las conclusiones indican que los clústeres universitarios son estrategias eficaces para el fomento del espíritu emprendedor.
ABSTRACT:
This document identifies the strategies used in diverse higher education institutions for enhancing entrepreneurial spirit in their undergraduate students, as well as the involvement of different actors of society through university clusters formation that allow high impact in entrepreneurship, innovation and solutions to social problems. This is possible through human resource training, disruptive thinking, knowledge generation and links with the productive, academic and governmental sectors. The conclusions show that university clusters are effective strategies for enhancing entrepreneurial spirit.
C´ómo mejorar la gestión del desempeño. / How to improve performance management.
Authors: Cravino Luis María 
Published: April 2021

En el marco del capital humano, la gestión del desempeño emergió como propuesta innovadora. Está probado que proporciona valor, pero se encuentra muy cuestionada. Este texto revisa la bibliografía con foco en las propuestas para su mejora, presentando los debates que la componen y nuevas herramientas para su implementación.
ABSTRACT:
In the field of human capital, performance management surfaced as an innovative proposal. It has proven to add value however, it’s deeply questioned. This text reviews its literature, focusing on the ideas for its improvement, presenting the debates that make it up and new tools for its implementation.
METHODS OF ADAPTATION OF SLANG UNITS INTO RUSSIAN IN THE LITERARY TRANSLATION OF M. COLE’ NOVELS
Authors: Мозжегорова Елена Николаевна , Засецкова Елена Николаевна 
Published: April 2021

Настоящая статья посвящена исследованию особенностей использования способов адаптации сленговых единиц в художественном переводе на русский язык следующих романов английской писательницы Мартины Коул: «Две женщины», «Леди киллер», «Опасная леди». В общей сложности было проанализировано 115 сленговых единиц из вышеназванных произведений. В работе были рассмотрены примеры перевода сленга и идентифицированы приемы передачи сленговой лексики на русский язык. Предметом настоящего исследования выступает адаптация сленга в художественном переводе на русский язык произведений Мартины Коул. Целью исследования являются изучение особенностей адаптации сленговых единиц при переводе художественной литературы на русский язык на материале произведений вышеуказанного автора. Для достижения поставленной цели исследования авторами были привлечены следующие методы: анализа и синтеза, сопоставительный и описательный, сравнения, метод контекстуального анализа и целостной интерпретации. В результате исследования было установлено, что в подавляющем большинстве случаев сленговые единицы удалось адаптировать к русскому языку. Самыми востребованными переводческими трансформациями для передачи сленговой лексики на русский язык явились подбор функционального аналога (в 50 случаях), дисфемистический перевод (в 34 случаях), эвфемистический перевод (в 21 случае), опущение (в 7 случаях) и прочие приемы перевода (калькирование, транслитерация).
This article is devoted to the study of the features of the use of methods of adaptation of slang units into Russian in the literary translation of the novels of the English writer Martina Cole (“Two Women”, “The Ladykiller”, “Dangerous Lady”). The article considers the examples of slang translation and identifies the methods of translation of slang vocabulary into Russian. A total of 115 slang items from the above works were analyzed. The subject of this research is the adaptation of slang in the literary translation of the works of Martina Cole into Russian. The goal of the study is to study the features of adaptation of slang units when translating fiction into Russian based on the works of the above-mentioned author. To achieve the set goal of the study, the authors used the following methods: the method of analysis and synthesis, comparative and descriptive methods, the method of comparison, the method of contextual analysis and holistic interpretation. The study revealed that in the overwhelming majority of the cases considered, the translators managed to adopt the slang units into Russian. The most popular translation transformations for slang vocabulary into Russian are a functional analogue (50 cases), dysphemistic translation (34 cases), euphemistic translation (21 cases), omission (7 cases) and other translation techniques (tracing, transliteration, omission).
TRAINING BASED ON DIGITAL PEDAGOGY AS A FACTOR IN IMPROVING THE QUALITY OF EDUCATIONAL SERVICES AND MODERNIZATION OF EDUCATION
Authors: Петрищев Игорь Олегович 
Published: April 2021

Стремительное развитие современного рынка образовательных услуг обусловливает необходимость детального исследования тенденций и закономерностей обучения на основе средств цифровой педагогики. Система создания и предоставления образовательных услуг определяется потребностью реализации оценки их качества. Актуальность проблемы обосновывается тем, что качество данных услуг обусловливает уровень интеллектуального потенциала государства, становится одной из важнейших предпосылок его экономической и политической стабильности, залогом конкурентоспособности на мировом рынке образовательных услуг. В статье проведен анализ цифрового обучения, его сущности, особенностей, преимуществ и потенциала в контексте образования, реализуемого в условиях цифровой экономики и информационного общества. Создание и развитие оптимальной системы сбора и обработки информации о качестве образования является на сегодняшний день одной из самых актуальных задач образовательной сферы. Обучение, построенное на основе применения средств цифровой педагогики, определяется как фактор модернизации образования и повышения качества образовательных услуг. Обращение к методам и формам цифровой педагогики, наряду с общепедагогическими подходами к обучению, позволяет оптимизировать учебно-воспитательный процесс и повысить качество предоставляемых образовательных услуг.
The rapid development of the modern market of educational services necessitates a detailed study of trends and patterns of learning based on digital pedagogy. The system of creation and provision of educational services provides for the need to implement a systematic assessment of the quality of services provided by educational institutions. The relevance of this problem is justified by the fact that the quality of services determines the level of intellectual potential of the state, becomes one of the most important prerequisites for its economic and political stability, and guarantees competitiveness in the world market of educational services. The article analyzes digital learning, its essence, features, advantages and potential in the context of education implemented in the digital economy and information society. Creating and developing an optimal system for collecting and processing information about the state of the quality of education is one of the most urgent tasks of the educational sphere today. Training based on the use of digital pedagogy is justified as a factor in modernizing education and improving the quality of educational services. Using the methods and forms of digital pedagogy, along with general pedagogical approaches to learning, allows one to optimize the educational process and improve the quality of educational services provided.
DEVELOPMENT OF THE MATHEMATICAL CULTURE OF FUTURE TEACHERS OF MATHEMATICS IN THE PROCESS OF PROFESSIONAL TRAINING AT THE UNIVERSITY
Authors: Фоминых Светлана Олеговна 
Published: April 2021

Подготовка будущего учителя математики представляет собой сложный процесс, поскольку в данной профессии выделяются две важные составляющие: технологическая и методологическая. В настоящей статье будет сделан акцент на таком проявлении методологического компонента профессии, как математическая культура. Сквозь призму современных педагогических концепций и технологий рассмотрен процесс методологической фундаментализации профессиональной подготовки будущего учителя математики и проведен анализ данного процесса. Основные положения аналитического обозрения основывались на состоянии современной образовательной системы, развитии цифровизации в культуре и науке, общей структуре математической культуры и математического развития личности человека. В связи с этим в заключительных положениях были сформулированы выводы относительно перечня компетенций, необходимых современному учителю математики в целях обеспечения его профессиональной эффективности. Обобщенный теоретический опыт может быть положен в основу актуальных обучающих программ и курсов для российских педагогических вузов, ведущих подготовку по специальности «учитель математики».
The training of a future Mathematics teacher is a difficult process, since there are two important components in this profession: technological and methodological. This article will focus on such a manifestation of the methodological component of the profession as mathematical culture. Through the prism of modern pedagogical concepts and technologies, the analysis of the process of methodological fundamentalization of the professional training of the future mathematics teacher is carried out. The main provisions of the analytical review were based on the state of the modern educational system, the development of digitalization in culture and science, the general structure of mathematical culture and the mathematical development of a person’s personality. In this connection, in the final provisions, conclusions were formulated regarding the list of competences necessary for a modern Mathematics teacher in order to ensure his professional effectiveness. Generalized theoretical experience can be used as the basis for current training programs and courses for Russian pedagogical universities providing the major of Mathematics Teacher.