bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Ozone Oxidative Preconditioning on Subarachnoid Hemorrhage via Rat Cerebral Vasospasm Model
Authors: Süslü Hikmet Turan , Tatarlı Necati , Ceylan Davut , Süslü Hüsnü , Bozkurt Süheyla Uyar , Avsar Timucin , Güçlü Bülent 
Published: March 2021

Objective:
Cerebral vasospasm after subarachnoid hemorrhage (SAH) is a major cause of morbidity and mortality. Inflammation is the major molecular mechanism observed in vasospastic SAH. Ozone (O3) has been used as a therapeutic agent in the treatment of various conditions and diseases for years. The aim of this study was to evaluate the anti-inflammatory effect of ozone oxidative preconditioning (OOP) in a rat model of SAH in order to assess the therapeutic potential of O3 in SAH therapy.

Materials and Methods:
In the presented study, an experimental in vivo SAH rat model that provided constriction of large cerebral arteries was used. The inflammatory response of cerebral vasospasm after SAH and the effects of OOP were evaluated by comparing the mRNA levels of inflammatory molecules (tumor necrosis factor-α, interleukin-1β, and intercellular adhesion molecule-1) in the serum samples of rats.

Results:
The level of inflammatory molecules increased in vasospasm at 12 h, 24 h, and 48 h in the posttreatment groups. However, intraperitoneal OOP decreased the level of inflammatory molecules dramatically.

Conclusions:
Our study indicated that O3 treatment has potential in the management of inflammation created in a rat SAH model. These findings may inform further studies investigating possible uses of O3 in the treatment of vasospasm.
Severe obesity associated with hyperglycemia and abdominal fats in metabolic syndrome patients
Authors: Musa Khansa Ibrahim , Ibrahim Mariam Abbas , Al Masri Mai Abderahman , Ismail Amar Mohamed 
Published: March 2021

Background:
Obesity is a major public problem in developed and developing countries associated with a high mortality rate. Herein, we determined the relationships between severe obesity, lipid profile, blood glucose in metabolic syndrome (MS) patients.

Materials and Methods:
In a cross-sectional 215 MS patients, ages ranged from 37 to 84 were randomly selected. Body mass index and waist circumference (WC) were estimated. Fasting serum lipid profile and plasma blood glucose were measured.

Results:
In total, 132 (61.4%) were female, 151 (70.2%) were obese, 64 (29.8%) were sever obese, and 143 (66.5%) had WC ≥ 110. Chi-square analyses show that severe obesity was significantly associated with increased WC and hyperglycemia with (odds ratio [OR] = 2.230 and 2.400) and (P = 0.019 and 0.005), respectively. The severe obesity in females was two-fold increased than males (OR = 1.93, P = 0.028).

Conclusion:
Severe obesity associated with central obesity and hyperglycemia in MS patients. Moreover, females at higher risk to have severe obesity.
A STUDY ON IMPACT OF BEHAVIOURAL FINANCE ON INVESTMENT DECISION OF SINGLE PARENTS IN SOUTH ASIAN COUNTRIES
Authors: Sendilvelu Kannadas , Shah Manita Deepak 
Published: March 2021

The purpose of this study is to find out the possible impact of behavioural finance on the investment decision of a single parent. As being an earning/working single parent who usually does not have other possible sources in their family, the decision which they take must be a reliable one and cannot afford to get a second chance. In the study, this study is also one of an effort to assess the impact of behavioural biases in the investment decision-making of a single parent. A questionnaire is designed and responses are collected from 203 respondents who prefer to invest where the level of risk is either low or moderate and are more concerned about losses in their investment than substantial gain. Also, most of the respondents were investing in order to meet some specific purpose, for their retirement plan as well as to educate their children. This study concludes by stating that investors’ risk-taking capacity is dependent on their level of income and the sources of income. Although every Individual is subject to some biases, they tend to think more rational way than an average investor in many ways as they know about their requirements and the investment they make.
JEL Classification Codes: G40, G41.
LA MOTIVACIÓN EN LOS PROCEDIMIENTOS DE SELECCIÓN Y ADJUDICACIÓN DE CONTRATOS Y CONCESIONES ADMINISTRATIVAS
Authors: NAVARRO GONZÁLEZ ROCÍO 
Published: March 2021

La reciente Ley 39/2015, de 1 de octubre, del Procedimiento Administrativo Común de las Administraciones Públicas no ha provocado cambio sustancial alguno en relación a la exigencia de la motivación de los actos que resuelvan procedimientos selectivos y de concurrencia competitiva, la cual ha de darse conforme a lo dispuesto en las normas que regulan las convocatorias, acreditándose, a su vez, los fundamentos de la resolución que se adopte, ya sea con una motivación individual para cada interesado, ya sea con una remisión al expediente. Del análisis de las diferentes fases de los procedimientos de contratación administrativa, se observa que la motivación, aparte de equipararse a una verdadera garantía inexcusable, mantiene su presencia de forma permanente y transversal en tales procedimientos específicos en la que resaltan diferentes y significativas peculiaridades de la misma.Duela gutxi urriaren 1eko 39/2015 Legea onetsi da, Administrazio Publikoen Administrazio Prozedura Erkidearena. Lege horrek ez du aldaketa nabarmenik ekarri hautaketa-prozesuak eta norgehiagokako prozedurak ebazten dituzten egintzak arrazoitzeko exijentziari dagokionez. Arrazoitzeko exijitu ahal da deialdiak arautzen dituzten arauetan xedatuta dagoenaren arabera, eta hala badagokio, hartzen den ebazpenaren funtsak egiaztatu behar dira, dela interesdun bakoitzari banaka arrazoiak emanez, dela espedientera jotzeko eskatuz. Administrazio-kontratazioko prozeduren faseak aztertuz, zera ikusten da: arrazoiak ematea, benetako berme saihestezinaren parekoa da, baina horrez gain, prozedura espezifikoetan etengabe eta zeharka agertzen jarraitzen du, berezitasun diferente eta esanguratsuak nabarmenduta.The recent Act 39/2015 of October 1st on the Common Administrative Procedure of Public Administrations has not led to substantive changes regarding the requirement of motivating acts that resolve selective and competitive procedures, which has to be delivered according to the provisions that rule the calls, certifying at the same time the grounds on which the resolution is adopted either with an individual motivation for each interested part or with reference to the file. On the basis of the analysis of the different phases in public procurement procedures, it is observed that motivation apart from qualifying as a true and inexcusable guarantee keeps its permanent and transversal presence in those specific procedures that remark its different and significant peculiarities.
COMPETENCIAS DE LOS MUNICIPIOS VASCOS: TIPOLOGÍA Y RÉGIMEN JURÍDICO
Authors: VELASCO CABALLERO FRANCISCO 
Published: March 2021

La Ley de Instituciones Locales de Euskadi (2016) incorpora varias
novedades importantes en relación con las competencias locales. Este sistema
habrá de ser completado con las leyes sectoriales del Parlamento vasco y con las
normas forales. De un lado, se enuncian con detalle las materias competenciales
municipales; en segundo lugar se introduce una distinción triple entre competencias
propias, transferidas y delegadas. Y, lo más importante, se establece un sistema
novedoso de garantía de la suficiencia financiera de las competencias municipales,
de manera que toda nueva atribución competencial debe llevar aparejada
una previsión «específica de financiación». Algunas de estas novedades (en especial
la previsión de suficiencia financiera de cada nueva competencia) deben ser
desarrolladas con cautela, para evitar que el fin municipalista al que sirven acaben
por limitar la autonomía local real.
Euskadiko Toki Erakundeei buruzko Legeak (2016) zenbait berrikuntza
garrantzitsu dakartza toki-eskumenei dagokienez. Sistema foru-arauekin eta
Eusko Legebiltzarreko sektoreko legeekin osatu behar da. Batetik, udal-eskumenen
arloak zehatz jaso dira; bigarrenik, eskumen propio, transferitu edo eskuordetuen
arteko bereizketa hirukoitza txertatu du. Eta, garrantzitsuena, udal-eskumenen
nahikoa finantzaketa bermatzeko sistema berritzailea ezarri da, gure eskumen eskuduntza
berri osoak «finantzaketa aurreikuspen zehatza» izan behar du, atxikita.
Berrikuntza horietako batzuk (bereziki eskumen berri bakoitzeko finantzaketa nahikoa
aurreikusteari dagokiona) kautelaz garatu behar dira, udal-helburuak ez dezan
mugatu tokiko autonomia erreala.
The Act on Local Institutions of Euskadi (2016) boasts several
important novelties in relation with local competences. This system eventually
shall be completed with specific legislation enacted by the Basque Parliament
and with foral laws. On the one hand, municipal competences areas are stated at
length; secondly, it introduces a threefold distinction between own, transferred
and delegated competences. And, more importantly, it establishes an innovative
system of guarantee for the financial sufficiency of the municipal competences
so that any new allocation of powers shall carry an up-front «specific provision
of financing». Some of these novelties (specially the provision for a financial
sufficiency attached to every new competence) have to be carefully implemented
in order to avoid that the municipal aim they serve does not restrict real local
autonomy.
FORMAS DE GESTIÓN DE LOS SERVICIOS PÚBLICOS LOCALES EN LA LEY NÚM. 2/2016, DE 7 DE ABRIL, DE INSTITUCIONES LOCALES DE EUSKADI
Authors: DEL GUAYO CASTIELLA IÑIGO 
Published: March 2021

El trabajo analiza el Título VIII de la Ley número 2/2016 de 7 de
abril, de instituciones locales de Euskadi, que versa sobre los servicios públicos
locales. En primer lugar, se persigue determinar cuál es el grupo normativo regulador
de esta materia. En segundo lugar, se hace un esfuerzo por deslindar entre
los servicios públicos locales y la iniciativa económica local, dada la relevancia de
tal distinción, en particular el concepto de reserva. En tercer lugar se pasa revista
a las diversas formas de gestión, tanto directas e indirectas, en el derecho vigente
(aun cuando se apunta cómo esto variará cuando se apruebe la nueva legislación
de contratos del sector público). En último lugar, se explica cómo el derecho vasco
da una preferencia a la gestión por el propio municipio, así como establece una
referencia (cuando el servicio no es prestado por el municipio) a la gestión compartida
sobre la gestión integrada.
Azterlanak Euskadiko Toki Erakundeei buruzko apirilaren 7ko
2/2016 Legearen VIII. titulua aztertu du, zeina tokiko zerbitzu publikoei buruzkoa
baita. Lehenik eta behin, arlo horren talde arautzaile erregulatzailea zein den zehaztea
lortu nahi da. Bigarrenik, tokiko zerbitzu publikoak eta tokiko ekimen ekonomikoa
bereizi nahi dira, bereizketa horrek daukan garrantzia aintzat hartuta, bereziki
erreserbaren kontzeptuari erreparatuta. Hirugarrenik, kudeaketa motak berrikusi
dira, zuzenekoak zein zeharkakoak, indarrean dagoen zuzenbidean (nahiz eta aipatu
den hori aldatu egingo dela sektore publikoko kontratuen legedi berria onartzerakoan).
Azkenik, aipatu da udalerriak berak kudeatzeari lehentasuna ematen
diola EAEko zuzenbideak; bidenabar, zerbitzua udalak ematen ez duenean kudeaketa
partekatua lehenesten du, kudeaketa integratuaren gainetik.
This work analyzes Title VIII of Act 2/2016 of April 7th on Local
Entities of Euskadi which deals with local public services. Firstly, it is pursued to
establish which the regulating normative group in this area. Secondly, an effort
is made to identify local public services and local economic initiative due to the
relevance of that distinction, particularly the concept of reserve. Thirdly, the several
forms of management both direct and indirect within the current law (although it
is outlined how with approval of new legislation on public procurement this will
be changed) are reviewed. Lastly, it is explained how Basque law gives preference
to the management by the own municipality to the shared management over the
integrated management and how it establishes a reference when the service is not
provided by the municipality.
ORGANIZACIÓN Y FUNCIONAMIENTO MUNICIPAL Y PERSONAL DIRECTIVO PÚBLICO PROFESIONAL
Authors: ETXEBARRIA ETXEITA IGNACIO JAVIER 
Published: March 2021

La Ley de Instituciones Locales de Euskadi regula la organización
y funcionamiento municipal y potencia la autonomía municipal al incrementar respecto
a la legislación estatal la capacidad de autoorganización de las entidades locales
posibilitando una actuación de los gobiernos locales más transparente y una
mejor conciliación de la vida laboral y familiar de las corporativas y corporativos.
La Ley busca asimismo potenciar los gobiernos locales y para ello incorpora
técnicas de delegación y de forma pionera regula la figura de los directivos públicos
profesionales si bien de momento limitada a los municipios con una población
superior a los 40.000 habitantes.
Euskadiko Toki Erakundeei buruzko Legeak udal-funtzionamendua
eta -antolaketa arautzen ditu, eta udal-autonomia indartzen du, estatuko legediarekin
erkatuta areagotu egin baitu tokiko entitateen autoantolakuntzarako
gaitasuna, bidea emanez tokiko gobernuek modu gardenagoan joka dezaten eta
hautetsiek lana eta familia hobeto uztar ditzaten.
Legeak, horrez gain, tokiko gobernuak indartzea lortu nahi du, eta, horretarako,
eskuordetze-teknikak jaso, eta modu aitzindarian arautu du zuzendari publiko profesionalen
figura; oraingoz, hala ere, 40.000 biztanletik gorako udalerrietarako mugatu
da.
The Act on Local Entities of Euskadi regulates the municipal
organization and functioning and enhances the municipal autonomy by increasing
as compared to the State legislation the self-government capacity of local entities
enabling a more transparent operation by local governments and a better labour
and family reconciliation of municipalities memberships. The Act also seeks to
promote local governments and to do this it includes techniques of delegation
and in a pioneer way it regulates the figure of public professional managers
though only limited to those municipalities with a population exceeding 40.000
inhabitants.
INSTRUMENTOS PARA LA PARTICIPACIÓN CIUDADANA Y REQUISITOS PARA SU EFECTIVIDAD
Authors: FERNÁNDEZ MARTÍNEZ JOSÉ LUIS , FONT FÀBREGAS JOAN , GARCÍA ESPÍN ANTONIA PATRICIA 
Published: March 2021

Los procesos participativos se ponen en marcha con objetivos de
distinta índole, por lo que no resulta sencillo abordar el análisis de su efectividad.
Estos procesos incorporan objetivos específicos como la producción de políticas
públicas (policies), o la promoción de cambios positivos en los contextos políticos
locales (polities). En este artículo, nos concentramos en esas dos dimensiones.
Nos planteamos en qué condiciones los procesos participativos generan nuevas
políticas públicas y en qué casos producen cambios significativos en los contextos
políticos locales. A través de un proyecto de investigación realizado entre 2012 y
2015, analizamos una diversidad de procesos participativos y reflexionamos sobre
sus límites y oportunidades a la hora de producir nuevas políticas o de crear nuevas
relaciones entre los actores públicos locales.
Parte hartzeko prozesuak hainbat helbururekin jartzen dira martxan,
eta, horrenbestez, horien eraginkortasuna aztertzea ez da erraza izaten. Prozesu
horiek helburu zehatzak izaten dituzte; esaterako, politika publikoak prestatzea
(policies), edo tokiko testuinguru politikoetan aldaketa positiboak sustatzea
(polities). Artikulu honetan bi dimentsio horiek ditugu hizpide: Parte hartzeko prozesuak
politika publiko berriak zein baldintzatan eragiten dituzten aztertu dugu,
eta aldaketa esanguratsuak zein kasutan eragin ditzaketen tokiko testuinguru politikoetan.
2012. eta 2015. urteen artean egindako ikerketa-proiektu baten bitartez,
parte hartzeko prozesu ugari aztertu ditugu, eta tokiko eragile publikoen arteko harreman
berriak sortu edo politika berriak ekoizteko orduan dituzten mugak eta aukerak
hausnarketarako gai izan ditugu.
Participative processes are implemented with different objectives
so it is not easy to address the analysis of their effectiveness. Theses processes
have specific objectives such as production of public policies or the promotion
of positive changes within local polities. In this article, we focus on those two
dimensions. We consider the conditions participative processes cause in local
policies and the cases where significant changes over local polities are produced.
By means of a research project developed between 2012 and 2015, we analyze the
diversity of participative processes and we reflect on their limits and opportunities
in order to produce new policies or create new relationships between local public
actors.
GESTÃO DA CONTABILIDADE GERENCIAL: UM ESTUDO DE CASO EM UMA EMPRESA COMERCIAL NO MUNICÍPIO DE ANANINDEUA NO PARÁ
Authors: Fernandes Assumpção Douglas Junio , De Souza Pianchão Marcela Maria , Santos Pinheiro Mário Jorge , Castro Paes Barreto Ellen Claudine , Melo de Oliveira Ediemerson 
Published: March 2021

O presente artigo apresenta como objeto de pesquisa as informações utilizadas pela contabilidade gerencial que contribuem como procedimentos de gestão para uma empresa comercial, no qual foi realizada uma análise bibliográfica sob a ótica contábil. Nesse contexto, o objetivo geral deste artigo é identificar quais são as informações aplicadas por uma contabilidade controlada, que possam contribuir no processo de gestão orientada em uma empresa, com o propósito de responder aos seguintes objetivos específicos: analisar como são tomadas as decisões para o gerenciamento empresarial; examinar quais as ferramentas possíveis a serem utilizadas e, desenvolver referências dos benefícios obtidos ao longo de uma contabilidade gerencial. A pesquisa qualifica-se como explicativa e descritiva. Os dados foram obtidos através de pesquisas bibliográficas, com abordagens de análises quantitativas e qualitativas. Os resultados encontrados indicam que a gestão da empresa possibilitou uma relevante transformação no papel desempenhado pelos contadores nas tomadas de decisões.
NA ERA TECNOLÓGICA, EM VIAS DO ESQUECIMENTO: ESTUDO DA ATUAL SITUAÇÃO EDUCACIONAL DE ESTUDANTES DE ALGUMAS ESCOLAS PÚBLICAS DO INTERIOR DA BAHIA, NO PERÍODO DA PANDEMIA COVID-19
Authors: BRANDÃO ELENILDA ALVES 
Published: March 2021

Este escrito traz uma abordagem sobre a visão de alguns estudantes do ensino fundamental II e do ensino médio de escolas públicas do interior da Bahia, sobre como pensam as suas atuais situações educacionais em meio à pandemia causada pela COVID-19, motivo o qual as aulas presencias foram totalmente suspensas. Sobre o prisma das (im)possibilidades do acesso às TICs pelos estudantes, observamos o possível alargamento das suas autonomias educacionais, bem como impulsionamento de suas posturas critica reflexivas e, a partir destas, a busca pelo empreendimento de suas próprias aprendizagens escolares. Buscamos externar as dificuldades de aprendizado em tempos pandêmicos; as exclusões digitais, cujas discrepâncias tornaram-se mais evidentes mediante a crise ocasionada pelo coronavírus. A partir de abordagem qualitativa e atividade de escuta dos sujeitos colaboradores em seus lugares e contextos, utilizando o instrumento entrevistas on line, buscamos dialogar com alguns autores como (Lemos, 2015); (Nicolaci–da-Costa, 2009); (Lévy 1999); (Silva, 2011); (Freire, 2006); (Amiél, 2018) e com os estudantes, jovens e adolescentes colaboradores buscando traçar uma imagem da realidade tangente a partir da visão destes sujeitos.
Palavras -chave: Escola pública. Pandemia. Estudantes. Exclusão digital. Autonomia.
KORKU VE BİYOTERÖRİZM EKSENİNDE COVİD-19’U ANLAMAK
Authors: TALAY Halim 
Published: March 2021

Dünya tarihinde bazı önemli olaylar bıraktıkları izler bakımından oldukça ses getirir. 2020 yılı ve meydana gelen Covid-19 salgını da bu noktada oldukça dikkatimizi celbetmektedir. Çin’de başlayan ve aşama aşama dünyaya yayılarak birçok insanın ölümüne sebebiyet veren salgının, dünya üzerinde önemli noktalarda yıkıcı etkileri olduğu müşahede edilmektedir. İnsanlığın ilk başlarda korku, panik ve ölüm korkusu ile karşıladığı mevcut durumda yumuşamalar olsa da tehlike halen devam etmektedir. Salgını kontrol alma adına devlet yönetimlerinin atmış olduğu adımlar, ekonomik ve siyasi kararlar sonrasında yaşanan gerilim ve kaoslar, konu üzerinde çeşitli teoriler oluşturulmasına yol açmıştır. Virüsün Çin’deki Wuhan şehrinde bir hayvan pazarından ya da oraya yakın viral araştırma laboratuvarından çıkmış olma söylentileri akıllara ilk olarak biyolojik silah ya da biyoterör ihtimalini getirmiştir. Gözle görülmeyen bir tehdit olması nedeni ile insanlarda büyük bir korku ve endişe atmosferi oluşturan virüsü kontrol altına almak için çeşitli kısıtlamalar uygulanmaya konulmuştur. Alınan tedbirler ağırlıklı olarak kişinin diğer insanlarla mesafeli olması, topluluktan kaçınması, evinden çıkmaması ve hareketlerini azaltması; işine, eğitimine ve toplantılarına uzaktan iletişimle devam etmesi şeklinde olmuştur. Bunun sonucunda da insanlığın aklına komplo teorileri ile karışık yeni sorular gelmektedir. Mevcut durumun yeni bir dünya ve insan algısı oluşturmak için ortaya çıkarıldığı gibi.
Bu çalışma Covid-19 ekseninde yaşanan tartışmalara ışık tutma amacı taşımaktadır. Özellikle, konuya biyoterör ve korku cephesinden yaklaşılarak, felsefi bir perspektif sunulmaya çalışılmıştır. Kavramların etimolojik kökeninden yola çıkarak bir anlama çabasında bulunmak da bu noktada mihenk taşlarından birini oluşturmaktadır.
Prognostic value of midkine, syndecan-1, hyaluronan
synthase-2, sestrin-1, laminin subunit alpha-4
and fibulin-3 for malignant pleural mesothelioma
Authors: Akgun Hakan , Metintas Selma , Ak Guntulu , Demirkol Canlı Secil , Isbilen Murat , Gure Ali , Metintas Muzaffer 
Published: March 2021

IntroductionThe prognosis of malignant pleural mesothelioma (MPM) is poor, with a limited survival time. In this study, we aimed to examine expression levels of genes selected from relevant literature and to utilize in silico methods to determine genes whose expression could reflect the prognosis of patients with MPM by ex-vivo validation experiments.Material and methodsThe study group consisted of 54 MPM patients treated with chemotherapy. Expression of 6 genes – midkine (MDK), syndecan-1 (SDC1), hyaluronan synthase-2 (HAS2), sestrin-1 (SESN1), laminin subunit alpha-4 (LAMA4), and fibulin-3 (FBLN3) – was examined by qPCR in tumor tissues. Sestrin-1 and LAMA4 were identified using an in house R-based script: Unsupervised Survival Analysis Tool. Midkine, SDC1, HAS2, and FBLN3 were selected from current literature. We used two housekeeping genes, i.e. glucose-6-phosphate dehydrogenase and TATA-box binding protein, as controls.ResultsOf the patients, 43 (79.6%) had epithelioid mesothelioma. The median survival for all patients was 10 (±1.2 SE) months (95% CI: 7.7–12.3). In multivariate analyses, MDK (p = 0.007), HAS2 (p = 0.008) and SESN1 (p = 0.014) expression levels were related to survival time in the whole group. In epithelioid type MPM patients, MDK (p = 0.014), FBLN3 (p = 0.029), HAS2 (p = 0.014) and SESN1 (p = 0.045) expression was related to survival time in multivariate analyses.ConclusionsHigh HAS2 and SESN1 expressions and low MDK are potential biomarkers of good prognosis in MPM. High HAS2 and SESN1 expression and low MDK and FBLN3 can also be utilized as biomarkers of good prognosis for epithelioid MPM. Those results should be further investigated in sera, plasma, and pleural effusions.