bluuebunny/crossref_metadata_2025_split huggingface dataset:
The EUMETSAT Polar System: 13+ Successful Years of Global Observations for Operational Weather Prediction and Climate Monitoring
Authors: Klaes K. Dieter , Ackermann Jörg , Anderson Craig , Andres Yago , August Thomas , Borde Régis , Bojkov Bojan , Butenko Leonid , Cacciari Alessandra , Coppens Dorothée , Crapeau Marc , Guedj Stephanie , Hautecoeur Olivier , Hultberg Tim , Lang Rüdiger , Linow Stefanie , Marquardt Christian , Munro Rosemarie , Pettirossi Carlo , Poli Gabriele , Ticconi Francesca , Vandermarcq Olivier , Vasquez Mayte , Vazquez-Navarro Margarita 
Published: March 2021

AbstractAfter successful launch in November 2018 and successful commissioning of Metop-C, all three satellites of the EUMETSAT Polar System (EPS) are in orbit together and operational. EPS is part of the Initial Joint Polar System (IJPS) with the United States (NOAA) and provides the service in the midmorning orbit. The Metop satellites carry a mission payload of sounding and imaging instruments, which allow provision of support to operational meteorology and climate monitoring, which are the main mission objectives for EPS. Applications include numerical weather prediction, atmospheric composition monitoring, and marine meteorology. Climate monitoring is supported through the generation of long time series through the program duration of 20+ years. The payload was developed and contributed by partners, including NOAA, CNES, and ESA. EUMETSAT and ESA developed the space segment in cooperation. The system has proven its value since the first satellite Metop-A, with enhanced products at high reliability for atmospheric sounding, delivered a very strong positive impact on NWP and results beyond expectations for atmospheric composition and chemistry applications. Having multiple satellites in orbit—now three—has enabled enhanced and additional products with increased impact, like atmospheric motion vector products at latitudes not accessible to geostationary observations or increased probability of radio occultations and hence atmospheric soundings with the Global Navigation Satellite System (GNSS) Radio-Occultation Atmospheric Sounder (GRAS) instruments. The paper gives an overview of the system and the embarked payload and discusses the benefits of generated products for applications and services. The conclusions point to the follow-on system, currently under development and assuring continuity for another 20+ years.
Large-Scale State and Evolution of the Atmosphere and Ocean during PISTON 2018
Authors: Sobel Adam H. , Sprintall Janet , Maloney Eric D. , Martin Zane K. , Wang Shuguang , de Szoeke Simon P. , Trabing Benjamin C. , Rutledge Steven A. 
Published: March 2021

AbstractThe Propagation of Intraseasonal Tropical Oscillations (PISTON) experiment conducted a field campaign in August–October 2018. The R/V Thomas G. Thompson made two cruises in the western North Pacific region north of Palau and east of the Philippines. Using select field observations and global observational and reanalysis datasets, this study describes the large-scale state and evolution of the atmosphere and ocean during these cruises. Intraseasonal variability was weak during the field program, except for a period of suppressed convection in October. Tropical cyclone activity, on the other hand, was strong. Variability at the ship location was characterized by periods of low-level easterly atmospheric flow with embedded westward propagating synoptic-scale atmospheric disturbances, punctuated by periods of strong low-level westerly winds that were both connected to the Asian monsoon westerlies and associated with tropical cyclones. In the most dramatic case, westerlies persisted for days during and after tropical cyclone Jebi had passed to the north of the ship. In these periods, the sea surface temperature was reduced by a couple of degrees by both wind mixing and net surface heat fluxes that were strongly (~200 W m−2) out of the ocean, due to both large latent heat flux and cloud shading associated with widespread deep convection. Underway conductivity–temperature transects showed dramatic cooling and deepening of the ocean mixed layer and erosion of the barrier layer after the passage of Typhoon Mangkhut due to entrainment of cooler water from below. Strong zonal currents observed over at least the upper 400 m were likely related to the generation and propagation of near-inertial currents.
Effect of educational lecture on the diagnostic accuracy of Japan NBI Expert Team classification for colorectal lesions
Authors: Okamoto Yuki , Oka Shiro , Tanaka Shinji , Kamigaichi Yuki , Tamari Hirosato , Shimohara Yasutsugu , Nishimura Tomoyuki , Inagaki Katsuaki , Tanaka Hidenori , Matsumoto Kenta , Yamashita Ken , Sumimoto Kyoku , Ninomiya Yuki , Hayashi Nana , Kitadai Yasuhiko , Yoshimura Kenichi , Chayama Kazuaki 
Published: March 2021

Abstract
Background
An educational and training program is required for generalization of Japan NBI Expert Team (JNET) classification. However, there is no detailed report on the learning curve of the diagnostic accuracy of endoscopists using JNET classification. We examined the effect of an educational lecture on beginners and less experienced endoscopists for improving their diagnostic accuracy of colorectal lesions by JNET classification.

Methods
Seven beginners with no endoscopy experience (NEE group), 7 less experienced endoscopists (LEE group), and 3 highly experienced endoscopists (HEE group) performed diagnosis using JNET classification for randomized NBI images of colorectal lesions from 180 cases (Type 1: 22 cases, Type 2A: 105 cases, Type 2B: 33 cases, and Type 3: 20 cases). Next, the NEE and LEE groups received a lecture on JNET classification, and all 3 groups repeated the diagnostic process. We compared the correct diagnosis rate and interobserver agreement before and after the lecture comprehensively and for each JNET type.

Results
In the HEE group, the correct diagnosis rate was more than 90% with good interobserver agreements (kappa value: 0.78–0.85). In the NEE and LEE groups, the correct diagnosis rate (NEE: 60.2 → 68.0%, P < 0.01; LEE: 66.4 → 86.7%, P < 0.01), high-confidence correct diagnosis rate (NEE: 19.6 → 37.2%, P < 0.01; LEE: 43.6 → 61.1%, P < 0.01), and interobserver agreement (kappa value, NEE: 0.32 → 0.43; LEE: 0.39 → 0.75) improved after the lecture. In the examination by each JNET type, the specificity and positive predictive value in the NEE and LEE groups generally improved after the lecture.

Conclusion
After conducting an appropriate lecture, the diagnostic ability using JNET classification was improved in beginners or endoscopists with less experience in NBI magnifying endoscopy.
Sputum smear grading and associated factors among bacteriologically confirmed pulmonary drug-resistant tuberculosis patients in Ethiopia
Authors: Kassa Getahun Molla , Merid Mehari Woldemariam , Muluneh Atalay Goshu , Fentie Dawit Tefera 
Published: March 2021

Abstract
Background
The sputum smear bacilliary load is a fundamental indicator of the level of infectiousness in DR-TB patients. However, evidence on DR-TB sputum smear grading and its factors in the study setting is limited. This study was aimed to determine the level of sputum smear grading and associated factors among DR-TB patients in Ethiopia.

Methods
This was an institution based cross-sectional study on 520 bacteriological confirmed pulmonary DR-TB patients from September 2010 to December 2017 in the northwest Ethiopia. Epidata 4.2.00 and SPSS 20 were used for data entry and management, respectively. Ordinary logistic regression was fitted. A cut of p-value less than 0.05 in the multivariable ordinary logistic regression was considered to declare statistically significant variables.

Results
Of all 520 bacteriological confirmed pulmonary DR-TB patients; 34.42% had 3+, 15.77% had 2+, 18.27% had 1+, 15.19% had scanty, and 16.35% had negative sputum smear grading results. The odds of having higher sputum smear grades were significantly associated with the patient’s educational status of secondary (Adjusted Odds Ratio (AOR) = 0.43, 95% Confidence Interval (CI): 0.21, 0.89), body mass index of 16 to 18.49 kg/m2 (AOR = 1.81, 95%CI: 1.16, 2.84), and TB treatment history of two and more times (AOR = 1.78, 95%CI: 1.24, 2.55).

Conclusions
More than a third of the bacteriological confirmed pulmonary DR-TB patients in the study setting was highly infectious with the highest bacillary load. The odds of having a high bacillary load were significantly associated with the patient’s TB treatment history, nutritional, and educational status.
Treatment patterns and outcomes in older women with early breast cancer: a population-based cohort study in China
Authors: Liu Xu , Zheng Dan , Wu Yanqi , Luo Chuanxu , Fan Yu , Zhong Xiaorong , Zheng Hong 
Published: March 2021

Abstract
Background
Despite the proportion of elderly breast cancer patients has been consistently increasing, the optimal treatment modalities for this population have not been well explored. We summarized the treatment outcomes of these patients in our hospital.

Methods
Older patients with early breast cancer were identified from the Breast Cancer Information Management System at West China Hospital, Sichuan University (2000–2019). We compared tumor characteristics and treatment outcomes between the older group (65–74 years old) and the elderly group (≥75 years old). The Kaplan-Meier and Cox regression analysis were conducted to determine significant prognostic factors.

Results
In total, 1094 patients were included. The median follow-up time for this cohort was 59 months. The majority of patients underwent surgery and benefited from surgical treatment. Elderly group patients were less likely to receive adjuvant chemotherapy or postmastectomy radiotherapy (PMRT) compared to the older group. However, adjuvant chemotherapy was associated with improved overall survival (OS) (hazard ratio [HR] 0.521, 95% confidence interval [CI] 0.284–0.955, P = 0.035). Subgroup analysis revealed that patients with grade III disease best benefited from adjuvant chemotherapy. PMRT offered a significant improvement in local disease control, but not in OS. Furthermore, endocrine therapy improved the OS of HR-positive patients (HR 0.440, 95%CI 0.261–0.741, P = 0.002), especially for cases aged 65–74 years. Also, receipt of trastuzumab in HER2-positive patients was associated with better OS (HR 0.168, 95%CI 0.029–0.958, P = 0.045).

Conclusions
Our findings suggest that surgery, adjuvant chemotherapy, endocrine and targeted therapy are associated with improved OS in older breast cancer patients. Moreover, clinicopathological characteristics should be comprehensively considered when making treatment decisions for these patients.
Disparities in influenza vaccination: Arab Americans in California
Authors: Jungquist Rose-Marie , Abuelezam Nadia N. 
Published: March 2021

Abstract
Background
Influenza vaccination among minoritized groups remains below federal benchmarks in the United States (US). We used data from the 2004–2016 California Health Interview Surveys (CHIS) to characterize influenza vaccination patterns among Arab Americans in California.

Methods
Influenza vaccination was self-reported by Arab American adults (N = 1163) and non-Hispanic Whites (NHW, N = 166,955). Differences in influenza vaccination prevalence and odds were compared using chi-squared tests and survey-weighted logistic regression, respectively.

Results
Across all years, 30.3% of Arab Americans self-reported receiving an influenza vaccine (vs. 40.5% for NHW, p < 0.05). After sequential adjustment by sociodemographic, health behavior, and acculturation variables no differences in odds of self-reported influenza vaccination were observed between Arab Americans and NHW (odds ratio: 1.02, 95% confidence interval: 0.76–1.38). Male and unemployed Arab Americans had higher odds of reporting influenza vaccination than female and employed Arab Americans.

Conclusions
Future work should consider specific barriers to influenza vaccination in Arab American communities.
Evaluation of parents' knowledge, attitudes, and practices regarding self-medication for their children’s dental problems during the COVID-19 pandemic: a cross-sectional survey
Authors: Sen Tunc Emine , Aksoy Emre , Arslan Hatice Nilden , Kaya Zeynep 
Published: March 2021

Abstract
Background
Self-medication refers to taking medicine without consultation with a doctor or dentist, and it is an important health issue, especially during the COVID-19 pandemic. There are no data about parents’ SM practices for their children’s dental problems during the COVID-19 pandemic. The present study aims to evaluate parents’ knowledge, attitudes, and practices regarding self-medication for their children’s dental problems during the COVID-19 pandemic in Northern Turkey.

Methods
A cross-sectional survey was carried out in the pediatric dental clinic at Ondokuz Mayis University, Faculty of Dentistry, Department of Pediatric Dentistry, immediately after the COVID-19 lockdown ended. A total of 389 parents who agreed to participate in the study completed the questionnaire from July 1 to October 1. A questionnaire with 18 items was designed to collect information on the parents’ knowledge and attitudes regarding when, why, and how to use drugs and on their practices on medicating their children. The collected data were analyzed using descriptive and analytical statistics (chi-square test).

Results
The majority of parents (n = 273; 70.2%) practiced self-medication for their children's dental problems. Self-medication with a previously prescribed medications was usually preferred by parents (n = 179; 62.2%). Analgesics (98%) were the most commonly used medicines by parents in their self-medication for their children's dental problems.

Conclusion
Prevalence of self-medication practices for children's dental problems is high in Turkey during the COVID-19 pandemic. Therefore, new healthcare services, such as teledentistry, may be useful to overcome problems related to the self-medication of children during times when the ability to reach healthcare providers is limited, such as during pandemics.
Isolation and identification of Candida tropicalis in sows with fatal infection: a case report
Authors: Zhai Lufeng , Zhou Ying , Wu Yingxia , Jin Yunyun , Zhu Qiaoyan , Gao Shengguo , Li Xuefeng , Sun Zhe , Xiao Yan , Huang Baicheng , Tian Kegong 
Published: March 2021

Abstract
Background
Candida is the common conditionally pathogenic fungus that infected human and animal clinically. C. tropicalis had been isolated from the skin and hair of healthy pigs, but with no report of fatal infection in gastrointestinal diseases.

Case presentation
In a pig farm in Henan Province of China, about 20 % of pregnant and postpartum sows suffered from severe gastrointestinal diseases, with a mortality rate higher than 60 % in the diseased animals. The sows had gastrointestinal symptoms such as blood in stool and vomiting. Necropsy revealed obvious gastric ulcers, gastrointestinal perforation, and intestinal hemorrhage in the gastrointestinal tract, but no lesions in other organs. The microbial species in gastric samples collected from gastric ulcer of the diseased sows then was initially identified as Candida by using routine systems of microscopic examination, culture characteristics on the medium Sabouraud dextrose agar medium. The fungus was further identified as C. tropicalis by species-specific PCR and sequencing. This study revealed an infection of C. tropicalis in sows through gastrointestinal mucosa could cause fatal digestive system disease and septicemia.

Conclusions
For the first time, a strain of C. tropicalis was isolated and identified from the gastric tissue of sows with severe gastrointestinal diseases. PCR and sequencing of ITS-rDNA combined with morphology and histopathological assay were reliable for the identification of Candida clinically.
Patient-centered care: achieving higher quality by designing care through the patient’s eyes
Authors: Edgman-Levitan Susan , Schoenbaum Stephen C. 
Published: March 2021

AbstractPatient centered care requires that health care organizations and health care professionals actively understand what patients value. Fortunately, there are methods for gaining that understanding. But, they need to be adopted much more widely, and patients need to be treated as full partners in their care.
Comparison of safety and effectiveness between 23-gauge and 25-gauge vitrectomy surgery in common vitreoretinal diseases
Authors: Sedova Aleksandra , Steiner Irene , Matzenberger Rene Peter , Georgopoulos Michael , Scholda Christoph , Kriechbaum Katharina Franziska , Abela-Formanek Claudette , Mylonas Georgios , Sacu Stefan , Schmidt-Erfurth Ursula , Pollreisz Andreas 
Published: March 2021

Purpose
To assess and compare safety and effectiveness between 23-gauge and 25-gauge vitrectomy systems for the treatment of common vitreoretinal diseases in non-vitrectomized eyes.

Methods
Retrospective evaluation of patients who underwent pars plana vitrectomy from April 2018 to December 2019 at the Department of Ophthalmology and Optometry at the Medical University of Vienna (MUV) for the following indications: macular epiretinal membrane, macular hole, macular lamellar hole, vitreous hemorrhage, vitreous opacities, vitreomacular traction syndrome and macular edema.

Results
201 eyes of 195 patients that underwent 23-gauge (n = 105 eyes) or 25-gauge (n = 96 eyes) vitrectomy were included in this study. The mean best-corrected visual acuity (BCVA) improved at 1–3 months postoperatively and beyond 3 months in both gauge groups. Risk of any complication within 1 month postoperatively was lower in the 25-gauge group, but the difference was statistically not significant (HR [95% CI]: 0.95 [0.53; 1.70], p = 0.85). Intraocular pressure less than 5 mmHg was observed in 2 eyes (2%) in the 23-gauge group at the first postoperative day. Intraocular pressure elevation over 25 mmHg occurred in 5 eyes (2 eyes, 2%, in 23-gauge and 3 eyes, 3%, in 25-gauge group) at postoperative day 1, between 7 and 28 days in 5 cases (2 eyes, 2%, in 23-gauge and 3 eyes, 3%, in 25-gauge group), and in 2 eyes (2%) of the 23-gauge group at postoperative day 145 and 61, respectively. Retinal detachment occurred in 1 eye (1%) in the 23-gauge and in 3 eyes (3%) in the 25-gauge group. We did not observe any cases of endophthalmitis.

Conclusion
Results in terms of safety, surgical success and visual outcomes for the treatment of common vitreoretinal surgery indications seem to be comparable between 23-gauge and 25-gauge vitrectomy systems, indicating that the two gauge systems can be used equally in the clinical routine.
Targeted Single-Cell RNA-seq Identifies Minority Cell Types of Kidney Distal Nephron
Authors: Chen Lihe , Chou Chun-Lin , Knepper Mark A. 
Published: March 2021

Significance Statement
A major objective in modern biology is generation of comprehensive atlases of various organs that identify all cell types and their expressed genes. In the kidney, extensive data describe proximal tubule and collecting duct cells but not the rarer intermediate epithelial cell types. Coupling of a cell enrichment protocol with single-cell RNA-seq analysis resolved the cellular composition and transcriptional profiles of the minority epithelial cell types of mouse kidney distal nephron. These data are provided in user-friendly websites that enable the mapping and comparison of genes of interest among cell types and renal tubule epithelia.

Background
Proximal tubule cells dominate the kidney parenchyma numerically, although less abundant cell types of the distal nephron have disproportionate roles in water and electrolyte balance.

Methods
Coupling of a FACS-based enrichment protocol with single-cell RNA-seq profiled the transcriptomes of 9099 cells from the thick ascending limb (CTAL)/distal convoluted tubule (DCT) region of the mouse nephron.

Results
Unsupervised clustering revealed Slc12a3
+/Pvalb
+ and Slc12a3
+/Pvalb
− cells, identified as DCT1 and DCT2 cells, respectively. DCT1 cells appear to be heterogeneous, with orthogonally variable expression of Slc8a1, Calb1, and Ckb. An additional DCT1 subcluster showed marked enrichment of cell cycle–/cell proliferation–associated mRNAs (e.g., Mki67, Stmn1, and Top2a), which fit with the known plasticity of DCT cells. No DCT2-specific transcripts were found. DCT2 cells contrast with DCT1 cells by expression of epithelial sodium channel β- and γ-subunits and much stronger expression of transcripts associated with calcium transport (Trpv5, Calb1, S100g, and Slc8a1). Additionally, scRNA-seq identified three distinct CTAL (Slc12a1
+) cell subtypes. One of these expressed Nos1 and Avpr1a, consistent with macula densa cells. The other two CTAL clusters were distinguished by Cldn10 and Ptger3 in one and Cldn16 and Foxq1 in the other. These two CTAL cell types were also distinguished by expression of alternative Iroquois homeobox transcription factors, with Irx1 and Irx2 in the Cldn10
+ CTAL cells and Irx3 in the Cldn16
+ CTAL cells.

Conclusions
Single-cell transcriptomics revealed unexpected diversity among the cells of the distal nephron in mouse. Web-based data resources are provided for the single-cell data.
Erosion Prediction Model using Fractional Vegetation Cover
Authors: Arif Nursida , Danoedoro Projo , Hartono Hartono , Mulabbi Andrew 
Published: March 2021

The purpose of this study was to create an erosion prediction model in Serang Watershed, Indonesia. The erosion model used two input data, namely the slope derivied from Digital Elevation Model (DEM) data, and Fractional Vegetation Cover (FVC) from SPOT images. Assessment of the model was carried out using questionnaires and interviews with several experts by presenting the results of the model and its supporting data. Based on the DEM data, the level of slope steepness in the study area is very varied namely; flat (52.77%), sloping (7.62%), and rather steep to very steep (39.59%). Vegetation density according to the FVC results is dominated by medium density. The results of the analysis of the two input models can provide predictions of the level of erosion with an accuracy of 67.92%. Evaluation of the model was done by experts with conclusions that the method was very flexible and can be adapted to similar watersheds elsewhere.
The Deployment of Drones in Sending Drugs and Patient Blood Samples COVID-19
Authors: Anggraeni Sri , Maulidina Aulia , Dewi Mauseni Wantika , Rahmadianti Salma , Rizky Yulian Putri Chandra , Arinalhaq Zulfa Fathi , Usdiyana Dian , Nandiyanto Asep Bayu Dani , Al-Obaidi Abdulkareem Sh. Mahdi 
Published: March 2021

At present, most countries all over the world are being hard hit by the COVID-19 pandemic and some even are being hit harder than others. This condition has caused widespread disruption of the economic, social, and educational systems in those countries. Under these conditions, transportation systems also need to be considered. There are problems of distribution of drugs and kits of test equipment to areas far from large cities in the center of the corona pandemic due to access difficulty. Remote locations, being difficult to reach, make the distribution of drugs and equipment for rapid testing uneven so that the recovery rate of patients in the area has a low percentage. Meanwhile, it is essential to ensure the availability of drugs and rapid test equipment in every public health center in all directions of Indonesia. One possible solution is the use of drones to distribute these things to areas that are difficult to reach. This solution is expected to at least improve healing and reduce mortality for patients infected with COVID-19 in remote areas.