bluuebunny/crossref_metadata_2025_split huggingface dataset:
AIEgen‐Based Lifetime‐Probes for Precise Furin Quantification and Identification of Cell Subtypes
Authors: Jia Hui , Ding Defang , Hu Jingjing , Dai Jun , Yang Juliang , Li Guogang , Lou Xiaoding , Xia Fan 
Published: September 2021

AbstractBiochemical sensing probes based on aggregation‐induced‐emission luminogens (AIEgens) are widely used in biological imaging and therapy, chemical sensing, and material sciences. However, it is still a great challenge to quantify the targets through fluorescence intensity of AIEgen probes due to their undesirable aggregations. Here, a PyTPA‐ZGO probe with three lifetime signals for precise quantification of furin is constructed: the lifetime signal 1 and signal 2 comes from AIEgen PyTPA‐P (τPn) and inorganic nanoparticles Zn2GeO4:Mn2+‐NH2 (τZn), respectively, while the lifetime signal 3 is marked as the composite dual‐lifetime signal (CDLSn, ). In contrast, the fluorescence intensity signal of PyTPA‐P shows defectively quantitative performance. Furthermore, it is found that the CDLSn exhibits higher significant differences than the two other lifetime signals (τPn and τZn) thanks to its wide range between the maximum and minimum signal values and small standard deviation. Therefore, CDLSn is further used to accurately identify cell subtypes based on the specific concentration of furin in each subtype. The lifetime criterion can realize precise quantification, and it should be a promising direction of AIEgen‐based quantitative analysis in the future.
Novel Architecture of Indoor Bifacial Dye‐Sensitized Solar Cells with Efficiencies Surpassing 25% and Efficiency Ratios Exceeding 95%
Authors: Venkatesan Shanmuganathan , Cho Yu‐Syuan , Liu I.‐Ping , Teng Hsisheng , Lee Yuh‐Lang 
Published: September 2021

AbstractTo prepare bifacial dye‐sensitized solar cells (DSSCs), the classical photoelectrode employing the main light‐absorbing layer (ML) and scattering layer (SL) will encounter the scattering effect of SL to the rear‐side incident light and, thereby, decrease the rear‐side efficiencies. To solve this problem, the SL has always been removed for the fabrication of bifacial cells. However, the front‐side efficiency decreases without the SL. Here, a novel structure of a TiO2 photoelectrode is developed for bifacial DSSCs to solve the contrary effect for cells with and without an SL, increasing both the front‐side and rear‐side efficiencies. This new structure is constructed by introducing an additional ML behind the SL of the traditional DSSC structure (ML/SL), creating a sandwich (ML/SL/ML) architecture of the TiO2 film. The results demonstrate that rear illuminated light can be harvested more efficiently by this photoelectrode because the light is absorbed first by the last ML before suffering the effect of the SL. By using D35 and XY1b as cosensitizers of the photoelectrode, the front‐side and rear‐side efficiencies of the bifacial cells can achieve 25.04% and 23.7%, respectively, under 1000 lux fluorescent lighting, which means a rear‐to‐front efficiency ratio of 95%. The cells also show high efficiencies under one‐sun conditions.
Long‐Range Charge Transportation Induced Organic Host–Guest Dual Color Long Persistent Luminescence
Authors: Huang Guanheng , Deng Ziqi , Pang Junhong , Li Jinghong , Ni Shaofei , Li Jian‐An , Zhou Chen , Li Hailin , Xu Bingjia , Dang Li , Li Ming‐De 
Published: September 2021

AbstractLong persistent luminescence (LPL) can store light energy in excited states and gradually release it as light. Organic host–guest systems provide a good platform for LPL, and single‐color LPL is often achieved while multicolor LPL is challengeable. Here host–guest supramolecular complexes are presented with dual LPL emissions: thermally activated delayed fluorescence (TADF) (≥100 ms) and room temperature phosphorescence (RTP). A space charge transfer from α‐cyclodextrin to diphenylacetylene (DPA) with long‐range transportation (2.32 mm) carrier along DPA strand in the supramolecular complexes is attributed to generate the TADF and RTP. Fortunately, these supramolecular complexes are readily fabricated from α‐cyclodextrin and DPA or DPA derivatives. The gradient color is observed after removing UV excitation. Furthermore, the hydrophobic property inside α‐cyclodextrin makes the LPL appear by water shedding and disappear by organic solvent infiltration, showing the character of a “switch.” This host–guest space charge transfer strategy paves a way to design LPL materials.
Tm2+ Activated SrB4O7 Bifunctional Sensor of Temperature and Pressure—Highly Sensitive, Multi‐Parameter Luminescence Thermometry and Manometry
Authors: Zheng Teng , Sójka Małgorzata , Runowski Marcin , Woźny Przemysław , Lis Stefan , Zych Eugeniusz 
Published: September 2021

AbstractNoninvasive sensing of temperature and pressure offers new and exciting opportunities to investigate and monitor the variation of physicochemical and spectroscopic properties of materials under extreme conditions. In this work, Tm2+‐doped SrB4O7 phosphor material—a novel, contactless bifunctional, and multimodal optical sensor for pressure and temperature is reported. A series of SrB4O7: xTm2+ samples are synthesized via a high‐temperature solid‐state method in air. The impact of high pressure (up to ≈13 GPa) and temperature (from 10 to 400 K) on spectroscopic properties of SrB4O7:Tm2+ is investigated. The emission band of Tm2+ demonstrates a significant spectral shift and a band broadening as a function of both pressure and temperature. Such a result is a consequence of a significant change of vibronic components of the Tm2+ 4f125d ↔ 4f13 zero‐phonon line. The emission bandwidth and its spectral position exhibit excellent sensitivities to pressure, that is, ≈23.17 and ≈−11.85 cm−1 GPa−1, respectively. Furthermore, for the first time, it is shown that temperature sensing can be realized via four different pathways in a single material: i) bandwidth, ii) band shift, iii) band intensity ratio, and iv) luminescence lifetime, with maximal sensitivities of ≈3.85 cm−1 K−1, 1.44 cm−1 K−1, 1.48% K−1 and 4.16% K−1, respectively.
Profitability of dual‐purpose rye cover crop as influenced by harvesting date
Authors: Sadeghpour Amir , Adeyemi Oladapo , Reed Bryan , Fry Jim , Keshavarz Afshar Reza 
Published: September 2021

AbstractHarvesting annual winter cereal rye (Secale cereale L.) (WCR) as an emergency forage could offset cover crop establishment costs, facilitate WCR adoption, and still provide multiple ecosystem benefits. A five site‐year trial was conducted in Colorado (CO) and Illinois (IL) to evaluate the effect of harvest date on WCR forage yield, quality, and its economic performance. From March to April, WCR dry matter (DM) yield increased exponentially in CO and linearly in IL. The DM yield at Julian day (DOY) 112–116 in CO was 6.9, 5.0, and 5.2 Mg ha–1 in 2018, 2019, and 2020, respectively, compared with 4.7 and 2.7 Mg ha–1 in IL in 2019 and 2020, respectively. Delayed harvesting increased acid detergent fiber and neutral detergent fiber concentrations and decreased crude, total digestible nutrients, and relative feed quality. Yield–quality trade‐off showed that forage yield increased rapidly but forage quality declined after DOY 105–108. Economic analysis, including cost of nutrient removal and 10% cash crop (corn [Zea mays L.]) yield penalty following WCR production revealed harvesting WCR biomass as forage was economically feasible in four out of five site‐years at hay price over $132 Mg–1. Eliminating corn yield penalty indicated profitability in four site‐years at hay price of ≥$110 Mg–1 and removing nutrient removal costs made all site‐years profitable at hay price of ≥$110 Mg–1. It was concluded that harvesting WCR biomass can be a profitable and effective strategy for sustainable intensification that can offer environmental stewardship and economic benefit.
Citizens or consumers? Seeking personhood through ‘personalised’ care in the National Disability Insurance Scheme
Authors: Piantedosi Diana Kate 
Published: September 2021

AbstractNational Disability Insurance Scheme (NDIS) funding rules determine who can access which supports. However, what is less frequently acknowledged, is that those rules produce an assumed model of personhood. Arguably, this becomes most evident when a case for funding reaches the Administrative Appeals Tribunal, where disputes are resolved between the administrators of the scheme (NDIA) and NDIS participants. In 2019, one such significant and controversial case asserted that ‘WRMF’, a woman living with multiple sclerosis, could use her NDIS funding to pay for the services of a sexual therapist. The basis for this ruling involved complex debates about citizenship and rights, which were embedded in contested notions of the person. In this paper, I use critical discourse analysis to examine these competing claims and the individualised framework in which WRMF's case was debated. The analysis reveals two key social justice issues: first, that there are limits to the citizenship available for people living with a disability (which assumes compulsory able‐bodiedness); second, that broader concepts of the person require explicit attention from the NDIS to embrace more expansive notions of citizenship for people living with a disability, including acknowledgement of sexual identities and needs.
Stepwise Generation of Mono‐, Di‐, and Triply‐Reduced Warped Nanographenes: Charge‐Dependent Aromaticity, Surface Nonequivalence, Swing Distortion, and Metal Binding Sites
Authors: Spisak Sarah N. , Zhou Zheng , Liu Shuyang , Xu Qi , Wei Zheng , Kato Kenta , Segawa Yasutomo , Itami Kenichiro , Rogachev Andrey Yu. , Petrukhina Marina A. 
Published: September 2021

AbstractThe stepwise chemical reduction of a molecular warped nanographene (WNG) having a negatively curved π‐surface and defined C80H30 composition with Cs metal used as the reducing and complexing agent allowed the isolation of three different reduced states with one, two, and three electrons added to its π‐conjugated system. This provided a unique series of nanosized carbanions with increasing negative charge for in‐depth structural analysis of consequences of controlled electron charging of non‐planar nanographenes, using X‐ray crystallographic and computational tools. The 3D molecular electrostatic potential (MEP) maps identified the negative charge localization at the central part of the WNG surface where selective coordination of Cs+ ions is confirmed crystallographically. In‐depth theoretical investigation revealed a complex response of the WNG to the stepwise electron acquisition. The extended and contorted π‐surface of the WNG undergoes subtle swinging distortions that are accompanied by notable changes in the electronic structure and site‐dependent aromaticity of the resulting carbanions.
Studying the Conversion Mechanism to Broaden Cathode Options in Aqueous Zinc‐Ion Batteries
Authors: Hao Junnan , Yuan Libei , Johannessen Bernt , Zhu Yilong , Jiao Yan , Ye Chao , Xie Fangxi , Qiao Shi‐Zhang 
Published: September 2021

AbstractAqueous Zn‐ion batteries (ZIBs) are regarded as alternatives to Li‐ion batteries benefiting from both improved safety and environmental impact. The widespread application of ZIBs, however, is compromised by the lack of high‐performance cathodes. Currently, only the intercalation mechanism is widely reported in aqueous ZIBs, which significantly limits cathode options. Beyond Zn‐ion intercalation, we comprehensively study the conversion mechanism for Zn2+ storage and its diffusion pathway in a CuI cathode, indicating that CuI occurs a direct conversion reaction without Zn2+ intercalation due to the high energy barrier for Zn2+ intercalation and migration. Importantly, this direct conversion reaction mechanism can be readily generalized to other high‐capacity cathodes, such as Cu2S (336.7 mA h g−1) and Cu2O (374.5 mA h g−1), indicating its practical universality. Our work enriches the Zn‐ion storage mechanism and significantly broadens the cathode horizons towards next‐generation ZIBs.
Rotation in an Enantiospecific Self‐Assembled Array of Molecular Raffle Wheels
Authors: Meier Dennis , Adak Abhishek K. , Knecht Peter , Reichert Joachim , Mondal Sourav , Suryadevara Nithin , Kuppusamy Senthil Kumar , Eguchi Keitaro , Muntwiler Matthias K. , Allegretti Francesco , Ruben Mario , Barth Johannes V. , Narasimhan Shobhana , Papageorgiou Anthoula C. 
Published: September 2021

AbstractTailored nano‐spaces can control enantioselective adsorption and molecular motion. We report on the spontaneous assembly of a dynamic system—a rigid kagome network with each pore occupied by a guest molecule—employing solely 2,6‐bis(1H‐pyrazol‐1‐yl)pyridine‐4‐carboxylic acid on Ag(111). The network cavity snugly hosts the chemically modified guest, bestows enantiomorphic adsorption and allows selective rotational motions. Temperature‐dependent scanning tunnelling microscopy studies revealed distinct anchoring orientations of the guest unit switching with a 0.95 eV thermal barrier. H‐bonding between the guest and the host transiently stabilises the rotating guest, as the flapper on a raffle wheel. Density functional theory investigations unravel the detailed molecular pirouette of the guest and how the energy landscape is determined by H‐bond formation and breakage. The origin of the guest's enantiodirected, dynamic anchoring lies in the specific interplay of the kagome network and the silver surface.
Strongly Coupled Cobalt Diselenide Monolayers for Selective Electrocatalytic Oxygen Reduction to H2O2 under Acidic Conditions
Authors: Zhang Xiao‐Long , Su Xiaozhi , Zheng Ya‐Rong , Hu Shao‐Jin , Shi Lei , Gao Fei‐Yue , Yang Peng‐Peng , Niu Zhuang‐Zhuang , Wu Zhi‐Zheng , Qin Shuai , Wu Rui , Duan Yu , Gu Chao , Zheng Xu‐Sheng , Zhu Jun‐Fa , Gao Min‐Rui 
Published: September 2021

AbstractElectrosynthesis of hydrogen peroxide (H2O2) in the acidic environment could largely prevent its decomposition to water, but efficient catalysts that constitute entirely earth‐abundant elements are lacking. Here we report the experimental demonstration of narrowing the interlayer gap of metallic cobalt diselenide (CoSe2), which creates high‐performance catalyst to selectively drive two‐electron oxygen reduction toward H2O2 in an acidic electrolyte. The enhancement of the interlayer coupling between CoSe2 atomic layers offers a favorable surface electronic structure that weakens the critical *OOH adsorption, promoting the energetics for H2O2 production. Consequently, on the strongly coupled CoSe2 catalyst, we achieved Faradaic efficiency of 96.7 %, current density of 50.04 milliamperes per square centimeter, and product rate of 30.60 mg cm−2 h−1. Moreover, this catalyst shows no sign of degradation when operating at −63 milliamperes per square centimeter over 100 hours.
Synthesis, Structure and Reactivity of a Cyapho‐Cyanamide Salt
Authors: Ergöçmen Doruk , Goicoechea Jose M. 
Published: September 2021

AbstractWe describe a facile synthesis of the cyapho‐cyanamide salt [Na(18‐crown‐6)][N(CN)(CP)] from reaction of [Na(18‐crown‐6)][PH2] (18‐crown‐6=1,4,7,10,13,16‐hexaoxacyclooctadecane) with dimethylN‐cyanocarbonimidate, (MeO)2C=N(CN). The reaction proceeds with elimination of two equivalents of methanol. Careful tuning of the reaction conditions allowed for the isolation and characterization of theN‐cyano(carboximidate)phosphide intermediate [HP{C(OMe)N(CN)}]−. Due to the adverse effects of methanol in these reaction mixtures, a bulk scale synthesis of [Na(18‐crown‐6)][N(CN)(CP)] could be achieved by addition of a base (LiHMDS) to neutralize the resulting alcohol. Further reactivity studies of this anion reveal that functionalization at the phosphorus atom is viable to yield a new family of cyanide‐functionalised phosphorus heterocycles.
Effects of thermal‐oxidative aging processes on tribological properties of polyformaldehyde and ultra‐high molecular weight polyethylene: A comparative study
Authors: Chen Song , Wei Lei , Cheng Bingxue , Shi Zhaoyao , Ding Yuejiao , Zhang Xiaohong , Duan Haitao 
Published: September 2021

AbstractUsing thermal‐oxidative aging and tribological experiments, effects of thermal‐oxidative aging processes on tribological properties of polyformaldehyde (POM) and ultra‐high molecular weight polyethylene (UHMWPE) were evaluated and compared with each other. It was found that the color of UHMWPE surface after aging has turned to yellow, while that of POM surface has no obvious change. The aging factors lead to dimensional change of UHMWPE disk specimens from the original circle to the ellipse in the meantime. Tribological experiments show that friction coefficients of the pairs of POM/GCr15 and UHMWPE/GCr15 tend to decrease after thermal‐oxidative aging, and the decreasing tendency in friction coefficients of POM/GCr15 is more distinct. The results of this study will contribute to the understanding of the relationship between aging and tribological properties of POM and UHMWPE, and enrich the theory of polymer tribology.
A poly(l‐lactic acid) braided stent with high mechanical properties during in vitro degradation in bile
Authors: Zhao Gutian , Tian Yuan , Hua Rixin , Liu Qingwei , Cheng Jie , Wu Gensheng , Zhang Yi , Ni Zhonghua 
Published: September 2021

AbstractIn this article, the mechanical properties and physicochemical indexes of a poly(l‐lactic acid) (PLLA) braided stent during in vitro degradation in bile for 270 days are characterized to investigate its applications in treating biliary strictures. The PLLA braided stent always maintains structural integrity well macroscopically without cracks or pits microscopically. During degradation, radial compressive force and chronic outward force are increased by 25.1% and 14.3%, respectively, bending stiffness and axial force are increased by 3.0% and 4.9%, respectively. These results indicate that PLLA braided stent can keep sufficient radial force and good bending performance during degradation in bile for 270 days, showing promising application prospects in treating severe benign biliary strictures demanding support for over half a year. Furthermore, almost no mass loss and 42.4% attenuation in molecular weight indicate the degradation mechanism of bulk erosion without obvious autocatalysis, causing decrease in bile pH. Degradation rate constant is 0.002 day−1 and crystallinity is increased by 8%. These results explain that PLLA braided stent can keep high mechanical properties during degradation in bile for 270 days, which is in the early stage of degradation. This study may bring new ideas into the applications of PLLA braided stents in treating biliary strictures.
Marine ecosystem science and the media: Exploring ways to improve news coverage through journalist–scientist working relations
Authors: Kolandai‐Matchett Komathi , Armoudian Maria , Thrush Simon , Hillman Jenny , Schwendenmann Luitgard , Jakobsson Julia , Haggitt Tim , O'Hara Blain Caitlin , Lear Gavin 
Published: September 2021

Abstract

The ocean's remoteness, ecological complexities, lengthy ecosystem processes, and vulnerability to multiple and cumulative anthropogenic threats make marine conservation communication particularly difficult. Both scientists and journalists face unique challenges in explaining the science of these often out‐of‐sight ecosystems. Given the inadequacies of marine news, improvement appeared necessary. However, the experiences and views of journalists and scientists have hardly been examined within marine news contexts. Thus, this study sought the perspectives of these two professional groups to provide a discussion on ways to improve news coverage of complex ocean issues through enhanced journalist–scientist working relations.
Both journalists and scientists rated the quantity, breadth and quality of marine news as average and were receptive to alternative ways for reporting ecosystem complexities. Although some frustrations remain, both valued impactful news stories resulting from their working relations and preferred direct contact with each other over indirect methods such as press releases and science news platforms. Both groups generally agreed on what to include in marine news, but scientists favoured a collaborative approach to news content decision‐making more strongly than journalists.
Journalists' and scientists' commonly shared views and goals concerning marine news identified in this study could serve as a common ground for uniting the two professions. Institutional policies that permit one‐on‐one journalist–scientist interactions could lead to mutual understandings about the contexts of their relationship challenges. More trustful and mutually beneficial relationships, in turn, could be a basis for a more collaborative news generation process. Compiling and making marine visuals readily accessible to journalists; training programmes that enhance journalists' and scientists' understanding of the influence of media message framing on conservation actions; media appreciation of marine ecosystem complexities' newsworthiness; and the notion of media's social responsibility in reporting marine conservation issues could contribute to more impactful coverage.
Thermal Expansion Properties and Mechanochemical Synthesis of Stoichiometric Cocrystals Containing Tetrabromobenzene as a Hydrogen‐ and Halogen‐Bond Donor
Authors: Ding Xiaodan , Crawford Adam W. , Derrick William P. , Unruh Daniel K. , Groeneman Ryan H. , Hutchins Kristin M. 
Published: September 2021

AbstractThe solution and mechanochemical synthesis of two cocrystals that differ in the stoichiometric ratio of the components (stoichiometric cocrystals) is reported. The components in the stoichiometric cocrystals interact through hydrogen or hydrogen/halogen bonds and differ in π‐stacking arrangements. The difference in structure and noncovalent interactions affords dramatically different thermal expansion behaviors in the two cocrystals. At certain molar ratios, the cocrystals are obtained concomitantly; however, by varying the ratios, a single stoichiometric cocrystal is achieved using mechanochemistry.
Individual cell‐based modeling of tumor cell plasticity‐induced immune escape after CAR‐T therapy
Authors: Zhang Can , Shao Changrong , Jiao Xiaopei , Bai Yue , Li Miao , Shi Hanping , Lei Jinzhi , Zhong Xiaosong 
Published: September 2021

AbstractChimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for refractory B cell malignancies, especially B‐cell acute lymphoblastic leukemia (B‐ALL). The majority of patients achieve a complete response following a single infusion of CD19‐targeted CAR‐modified T cells (CAR‐19 T cells); however, many patients suffer relapse after therapy, and the underlying mechanism remains unclear. To better understand the mechanism of tumor relapse, we developed an individual cell‐based computational model based on major assumptions of the tumor cells heterogeneity and plasticity as well as the heterogeneous responses to CAR‐T treatment. Model simulations reproduced the process of tumor relapse and predicted that cell plasticity induced by CAR‐T stress can lead to tumor relapse in B‐ALL. Model predictions were in agreement with experimental results of applying the second‐generation CAR‐T cells to mice injected with NALM‐6‐GL leukemic cells, in which 60% of the mice relapse within 3 months, relapsed tumors retained CD19 expression but exhibited a subpopulation of cells with high level CD34 transcription. The computational model suggests that the experimental data are compatible with a CAR‐T cell‐induced transition of tumor cells to hematopoietic stem‐like cells and myeloid‐like cells, which are resistant to the treatment. The proposed computational model framework was successfully developed to recapitulate the individual evolutionary dynamics and potentially allows to predict the outcomes of CAR‐T treatment through model simulation based on early‐stage observations of tumor burden and tumor cells analysis.