bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rate of breast biopsy referrals in BRCA mutation carriers: a retrospective comparative study and matched analysis
Authors: Pomerantz Adi , Tsoref Daliah , Grubstein Ahuva , Wadhawker Sonya , Rapson Yael , Gadiel Itay , Goldvaser Hadar , Hammerman Ariel , Shochat Tzipora , Sharon Eran , Yerushalmi Rinat 
Published: July 2021

Abstract
Purpose

To evaluate the total biopsy and positive biopsy rates in women at high risk of breast cancer compared to the general population.
Methods

The study group consisted of 330 BRCA mutation carriers attending the dedicated multidisciplinary breast cancer clinic of a tertiary medical center in Israel. Clinical, genetic, and biopsy data were retrieved from the central healthcare database and the medical files. Patients who were at age 50 years or older during follow-up were matched 1:10 to women in the general population referred for routine breast cancer screening at the same age, as recommended in the international guidelines. The groups were compared for rate of biopsy studies performed and percentage of positive biopsy results. Matched analysis was performed to correct for confounders.
Results

The matched analysis revealed that the total biopsy rate per 1000 follow-up-years was 61.7 in the study group and 22.7 in the control group (p < 0.001). The positive biopsy rates per 1000 follow-up-years were 26.4 and 2.0, correspondingly (p < 0.001), and the positive biopsy percentages were 42.9% and 8.7% correspondingly (p < 0.0001).
Conclusions

BRCA mutation carriers who attend a dedicated clinic, have a 2.7 times higher biopsy rate per 1000 follow-up-years, a 13.2 times higher positive biopsy rate per 1000 follow-up-years, and a 4.9 times higher positive biopsy percentage compared with women in the general population.
The Association Between Proton Pump Inhibitors and Incident Asthma in Patients with Coronary Artery Disease: A Population-Based Cohort Study
Authors: Lin Tsung-Kun , Huang Jing-Yang , Tsai Chin-Feng , Pan Lung-Fa , Jong Gwo-Ping 
Published: July 2021

Abstract
Observational studies have found a significant association between acid-suppressive drug use and incident asthma. However, the association between proton pump inhibitors (PPIs) and incident asthma in patients with coronary artery disease (CAD) is unclear. Thus, this study assessed the association between PPI use and incident asthma in patients with CAD. We conducted a retrospective cohort study using the National Health Insurance Research Database in Taiwan from 2004 to 2013. Each patient who took PPIs was assigned to the PPI group, whereas 1:1 sex-, age-, and drug index date-matched randomly selected patients without PPI prescription were assigned to the non-PPI group. We analyzed the risk of incident asthma using Cox proportional hazard regression models, including sex, age, urbanization, low income, and comorbidities. Sensitivity and subgroup analyses were also conducted. A total of 8499 cases were identified as PPI‐treated patients, and 8,499 subjects were included in the control group of PPI non‐users. After adjusting for sex, age, urbanization, low income, and comorbidities, PPI user was associated with a 1.18-fold (HR: 1.18; 95% CI: 1.05–1.34) increase for incident asthma in patients with CAD. We concluded that PPI use increased the risk of incident asthma in patients with CAD. The risk of incident asthma should be considered when weighing the benefits and risks of PPI and aspirin treatment in patients with CAD in clinical practice.
The Effect of Parathyroidectomy Compared to Non-Surgical Surveillance on Kidney Function in Primary Hyperparathyroidism: A Nationwide Historic Cohort Study
Authors: Matzen Josephine , Bislev Lise Sofie , Sikjær Tanja , Rolighed Lars , Hitz Mette Friberg , Eiken Pia , Hermann Anne Pernille , Jensen Jens-Erik Beck , Abrahamsen Bo , Rejnmark Lars 
Published: July 2021

Abstract
Background: Patients with primary hyperparathyroidism (pHPT) and impaired kidney function (estimated glomerular filtration rate (eGFR) <60 mL/min) are offered parathyroidectomy (PTX) to protect them from further complications. Surprisingly, two recent uncontrolled cohort studies have suggested a further decrease in kidney function following PTX. We aimed to examine the effects of PTX compared to non-surgical surveillance on kidney function in pHPT patients.Methods: Historic cohort study. From the Danish National Patient Registry (NPR) and major medical biochemistry laboratories in Denmark, we identified 3585 patients with biochemically confirmed pHPT among whom n=1977 (55%) were treated with PTX (PTX-group) whereas n=1608 (45%) were followed without surgery (non-PTX group). Baseline was defined as time of diagnosis and kidney function was re-assessed 9-15 months after PTX (PTX group) or 9-15 months after diagnosis (non-PTX group).Results: At follow-up, eGFR had decreased significantly in the PTX- compared to the non-PTX-group (median -4% vs. -1%, p<0.01). Stratification by baseline eGFR showed that the decrease was significant for those with a baseline eGFR value of 80-89 and >90 mL/min, but not for those with lower eGFR values. Findings did not differ between patients with mild compared to moderate/severe hypercalcemia. However, after mutual adjustments, we identified baseline levels of calcium, PTH, and eGFR as well as age and treatment (PTX vs. no-PTX) as independent predictors for changes in kidney function.Conclusion: Compared to non-surgical surveillance, PTX is associated with a small but significant decrease in kidney function in pHPT patients with an initial normal kidney function.
Contextual factors influencing physicians’ perception of antibiotic prescribing in primary care in Germany - A prospective observational study
Authors: Queder Annika , Arnold Christine , Wensing Michel , Poß-Doering Regina 
Published: July 2021

Abstract
BackgroundAntimicrobial resistance is a worldwide challenge for health services and systems alike. To reduce the overuse of antibiotics, multifaceted interventions are often used to achieve sustainable effects. It can be assumed that these effects are influenced by contextual factors. Embedded in the cluster randomized trial ARena (Sustainable reduction of antibiotic-induced antimicrobial resistance), the aim of this present study was to identify contextual factors associated with practitioners’ perceptions of antibiotic prescribing in German primary health care.MethodsIn a prospective observational study, data were generated in a three-wave survey study between January 2018 and July 2019. Analysis was performed using logistic regression models. The outcome of interest was the physician perceived impact of participating in the ARena project on decision-making regarding antibiotic prescribing, the independent variables of interest included individual characteristics, intervention arm allocation, primary care network (PCN) environment and characteristics of the medical practice.Results46.8% (n = 126) of participants indicated to have perceived an impact on their decision-making regarding antibiotic prescribing by participating in the ARena project. Bivariate logistic regression analyses indicated that work experience (odds ratio (OR) 1.05, 95% confidence interval (CI) 1.006–1.103), PCN environment (OR 2.06, 95% CI 1.256–3.363), structural conditions (OR 1.66, 95% CI 1.161–2.371), environment of existing processes (OR 1.46, 95% CI 1.011–2.094), and externally defined general conditions (OR 1.57, 95% CI 1.035–2.378) were associated with physicians’ perceived impact of participating in the ARena project on decision-making regarding antibiotic prescribing. In the multivariate logistic regression analysis, only work experience OR 1.05 (95% CI 1.001–1.104) continuously showed a significant influence.ConclusionsThis study indicates that contextual factors at individual, practice, and system level influence physicians’ perceptions of antibiotic prescribing.Trial registrationISRCTN, ISRCTN58150046 (registered 13.09.2017).
Quantification of KRAS Gene Mutations in the Resection or Venous Margins of Pancreatic Ductal Adenocarcinomas Is Not Predictive of Disease Recurrence
Authors: Amintas Samuel , Fernandez Benjamin , Chauvet Alexandre , Chiche Laurence , Laurent Christophe , Belleannée Geneviève , Marty Marion , Buscail Etienne , dabernat sandrine 
Published: July 2021

Abstract
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) patients eligible for curative surgery undergo unpredictable disease relapse. Post-surgery tools’ prognostic value is insufficient. Even patients with good pathological response after neo-adjuvant treatment (NAT) remain susceptible to recurrent PDAC. Molecular analysis of R0 margins may identify patients with worse prognosis. Methods: Retrospective analysis of patients, either eligible for up-font surgery (UFS, n=17) or resected patients who underwent NAT with good pathological responses (n=18), collected progression-free and overall survivals 33 months ±17 months post-surgery and examined the molecular status of mutant KRAS by droplet digital PCR.Results: Expectedly, KRAS mutant allele frequencies (MAF) were higher in UFS than in NAT tumor tissues or remnants, and in the ypT1 than the ypT0 tumors in the NAT group. Mutant KRAS positivity or MAFs in margins did not identify patients with detectable pathological disease in the NAT group, nor was it predictive of shorter recurrence-free or overall survival within or between groups. KRAS-double positivity in both venous and tumor resection margins did not identify patients with worse prognosis, regardless of the groups.Conclusion: The cohorts ‘sizes were small due to limited numbers of patients meeting the inclusion criteria, but KRAS-positivity or MAFs in resection and venous margins did not carry prognostic value. Comparison of margins from good versus bad responders receiving NAT may carry a better clinical value.
The Efficacy of High-flow Oxygen Versus Conventional Oxygen for Asthma Control: A Meta-analysis of Randomized Controlled Studies
Authors: Li Juan , Jiang Jialing , Wang Kaijin 
Published: July 2021

Abstract
Introduction: The efficacy of high-flow oxygen versus conventional oxygen therapy for asthma control remains controversial. We conduct a systematic review and meta-analysis to explore the influence of high-flow oxygen versus conventional oxygen therapy on asthma control. Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2021 for randomized controlled trials (RCTs) assessing the efficacy of high-flow oxygen versus conventional oxygen therapy for asthma control. This meta-analysis is performed using the random-effect model.Results: Four RCTs are included in the meta-analysis. Overall, compared with conventional oxygen therapy for asthma, high-flow oxygen is associated with significantly lower dyspnea score (SMD=-0.63; 95% CI=-1.08 to -0.17; P=0.008), but reveals no remarkable influence on PaCO2 (SMD=0.28; 95% CI=-0.22 to 0.77; P=0.28), PaO2 (SMD=0.44; 95% CI=-1.34 to 2.22; P=0.63), intubation (OR=1.09; 95% CI=0.15 to 8.21; P=0.93) or hospital length of stay (SMD=-0.07; 95% CI=-0.41 to 0.27; P=0.67). Conclusions: High-flow oxygen may benefit to reduce dyspnea score than conventional oxygen therapy for asthma.
Assessment of COVID-19 Vaccination Intention Among Community Health Workers: a Web-based Cross-sectional Survey During the First Wave of the Pandemic in India
Authors: Goel Kapil , Sen Arunima , Goel Parul , Satapathy Prakasini , Vij Jatina , Jain Lovely , Patro Binod , Singh Ritesh , Sekhar Sitanshu , Chakrapani Venkatesan , Pala Star , Sankhe Lalit , Modi Bhavesh , Bali Surya , Nadda Anuradha , Kiran Tanvi , Rajagopal Vineeth , Aggarwal Arun Kumar , Gupta Madhu , Padhi Bijaya K 
Published: July 2021

Abstract
Background: Vaccine hesitancy is of considerable concern as it threatens the great potential of a vaccine against COVID-19. Community health workers (CHWs) bridge the gap between the community and the health care system. Their intention to get vaccinated will not only affect them but will also affect the community’s perception of the vaccine. This study aims to understand the intention to get vaccinated against COVID-19 among community health care workers in India and its determinants.Methods: A web-based, cross-sectional study was conducted among 357 community health workers using snowball sampling. A self-administered anonymous questionnaire was shared with study participants across major geographical regions in India through social media during the first wave (November-December 2020).Results: Among 357 community health workers, 208 (58%) responded positively regarding their intention to get a COVID-19 vaccine. Graduate [aOR 2.26 (95% CI: 1.27-4.01), p=0.006] and post-graduate participants [aOR 2.85 (95% CI: 1.43-5.68), p=0.003], those with lower risk perception [aOR 1.86 (95% CI: 1.03-3.35), p=0.038] and respondents who trusted the healthcare system [aOR 2.60 (95% CI:1.59-4.26), p<0.001] were more likely to get vaccinated. Respondents who were exposed to COVID-19 cases were less likely to uptake the hypothetical vaccine [aOR 0.57 (95% CI: 0.34-0.96), p=0.034].Conclusions: Increasing knowledge regarding the COVID-19 vaccine might not be enough to improve vaccine acceptance rates. Enhancing trust among community health workers in the healthcare system and regarding the available vaccines seem necessary. In addition, targeted interventions addressing socio-demographic determinants related to COVID-19 vaccination should help improve acceptance of the vaccine.
Probing the troublesome peaked relationship between avian species richness and natural land cover
Authors: De Camargo Rafael Xavier , Currie David 
Published: July 2021

Abstract
Context : Biodiversity models postulate that the relationship between richness and the proportion of natural land cover (pNLC i.e., not dominated by human uses) is: 1) monotonic positive, 2) reasonably strong , 3) consistent in different geographic areas . Earlier work examining 100-km 2 human-dominated landcover in Ontario, Canada, observed that surveyed avian species richness is a peaked function of pNLC. Objective : We tested whether the same relationship between avian species richness and pNLC is also observed in an independent geographic area that has similar biomes. We also tested whether the peaked relations might be caused by temperature gradients, gradients in the size of species pools, grain size in the analyses, and landscape heterogeneity. Methods : Using breeding bird atlases of Ontario (Canada) and New York State (USA), we estimated species richness in landscapes varying from 25 to 900 km 2 . We related richness to the pNLC in each landscape and examined the same relationships after controlling for temperature, habitat heterogeneity, and species pool size. Results : Landscape-level species richness is a peaked, and not very strong function of pNLC. The relationship is not an artefact of temperature gradients, species pool size, or land cover heterogeneity. Conclusions : The proposition that increased amounts of natural land cover promotes species richness is clearly true at the limit, in landscapes with relatively little (<30%) natural cover. In landscapes with higher amounts of natural cover, a certain amount of human-modified land covers can provide habitat for species that prefer open habitats.
Factors associated with inappropriate overdose response among people who use prescription opioids non-medically in rural Appalachia: A cross-sectional study
Authors: Macmadu Alexandria , Gurka Kelly K. , Linn Herbert I. , Smith Gordon S. 
Published: July 2021

Abstract
Background

Opioid-related overdose deaths have accelerated in recent years. In response, overdose education and naloxone distribution (OEND) programs have been implemented across the United States, although many rural Appalachians continue to lack access. Despite the growing number of OEND programs, risk factors for inappropriate overdose response among persons who are training-naïve are currently unknown.
Methods

We used respondent-driven sampling to recruit and enroll 169 adults who use prescription opioids non-medically from three rural counties in West Virginia. Participants were interviewed to ascertain experience with witnessed overdose (lifetime and prior-year), characteristics of the most recent witnessed overdose, responses to the witnessed overdose, and OEND acceptability. Logistic regression was used to assess factors associated with inappropriate response to opioid-related overdose.
Results

Among the 73 (43% of the total sample) participants who witnessed an opioid-related overdose, the majority (n = 53, 73%) reported any inappropriate response. Participants were significantly more likely to report an inappropriate overdose response when the overdose victim was unresponsive (OR = 3.36; 95% CI = 1.07, 10.58). The most common appropriate responses were staying with the victim until recovery or help arrived (n = 66, 90%) and calling 911 (n = 63, 86%), while the most common inappropriate responses were hitting or slapping the victim (n = 37, 51%) and rubbing the victim with ice or placing them in a cold shower or bath (n = 14, 19%). While most (n = 60, 82%) had never heard of overdose prevention training, the vast majority (n = 69, 95%) were willing to participate in training, particularly those who had responded inappropriately (n = 52, 98%).
Conclusions

These findings underscore the urgent need for expanded access to OEND programs in at-risk rural communities that lacked coverage. Indeed, information generated by this study informed the development of a statewide naloxone distribution program in WV. These findings also indicate OEND programs are highly acceptable to training-naïve people who use opioids in rural Appalachia. Additional approaches to expand access to harm reduction services in the region, including mobile services and mail-based naloxone distribution should be aggressively pursued.
Can Paraspinal Muscle Degeneration Be a Reason for Refractures After Percutaneous Kyphoplasty? A Magnetic Resonance Imaging Observation
Authors: Zhao He , He Yan , Yang Jun-Song , Bao Wei , Chen Jian , Liu Ji-Jun , Li Qing-Da , Liu Peng , Qian Bing , Zhao Yuan-Ting , Hao Ding-Jun 
Published: July 2021

Abstract
Background: Vertebral augmentation (VA) techniques are used to treat acute osteoporotic vertebral compression fractures (OVCFs). However, the incidence of recurrent vertebral fractures after VA is controversial. Various factors have been discussed in the literature, but no convincing study on the quality of paraspinal muscles has been reported. The purposes of this study were to evaluate the changes in paraspinal muscles and discuss the relationship between paraspinal muscle degeneration and vertebral refractures after percutaneous kyphoplasty (PKP).Methods: This retrospective study was conducted in patients who underwent PKP for an initial OVCF between July 2017 and August 2018. Patients were followed up and categorized in the refractured or non-refractured group. A final magnetic resonance imaging (MRI) scan and a preoperative MRI scan were used to determine the measurements. The paraspinal muscles at the mid-height level of the initial fractured vertebral body were measured using regions of interest (ROIs), including the cross-sectional area (CSA) and signal intensity (SI). The changes in the observed data were compared between the groups using rank-sum tests.Results: Overall, 92 patients were enrolled in the study; 33 of them sustained vertebral refractures during the follow-up and the other 59 patients did not. There were no significant differences in terms of sex, age, preoperative bone mineral density, and body mass index between the groups (all, P>0.05). The refractured group had a significantly higher decrease in the ROI-CSA and CSA/SI, and a higher increase in ROI-SI, compared with the preoperative data (all, P<0.05).Conclusions: The quality of paraspinal muscles significantly decreased in patients with new OVCFs after PKP. This brings a new perspective to the study of postoperative recurrent fractures; patients and physicians need to pay more attention to the efficacy of bed rest and bracing.
Classification of potential pathways affecting the VEGF pathway in glioblastoma multiforme (GBM) recurrent: A bioinformatics study based on differentially expressed- microRNAs
Authors: Hadizadeh Morteza , Soltani Ramin , Langaee Taimour , pirouz Marziye Shad , Mozafari M. R. , Ghasemi Sorayya 
Published: July 2021

Abstract
Glioblastoma multiforme (GBM) resistance to anti-angiogenesis drugs results in recurrence of the disease which leads to death. The resistance to anti-angiogenesis drugs that target the VEGF pathway is due to the influence of other pathways. This study aimed to identify and classify the pathways that are related to the VEGF pathway in GBM recurrent. The identification of differentially expressed miRNAs (DEmiRNAs) based on GBM GSE profiles (GSE32466) were carried out using a LIMMA R package and VEGF pathway genes in the KEGG database. Pathways related to DEmiRNAs and VEGF pathway genes were discovered by DIANA-miRPath v3.0, NetworkAnalyst and ToppGene databases, respectively. Inhibitory or activity affecting pathways relating to VEGF pathway were obtained based on XTalkDB database. The classification was determined by the KEGG database. There were 1014 genes that were found to have interaction with VEGF signaling pathway genes. One hundred ninteen pathways were achieved which have overlapping genes with the VEGF pathway genes. The MAPK pathway had the most in common genes with the VEGF pathway (39 genes). A total of 91 pathways were identified in 24 different classes. Several pathways significantly affect the VEGF pathway. Hence, it seems necessary to achieve new targets for combination therapies for GBM.