bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assisted reproductive technology in Japan: A summary report for 2019 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology
Authors: Katagiri Yukiko , Jwa Seung Chik , Kuwahara Akira , Iwasa Takeshi , Ono Masanori , Kato Keiichi , Kishi Hiroshi , Kuwabara Yoshimitsu , Harada Miyuki , Hamatani Toshio , Osuga Yutaka 
Published: December 2021

AbstractPurposeThe Japan Society of Obstetrics and Gynecology records online annual cycle‐based information for assisted reproductive technology (ART). This report presents the characteristics and treatment outcomes of ART cycles registered during 2019.MethodsThe Japanese ART registry includes cycle‐specific information from 619 participating facilities, including treatment and pregnancy outcomes. Descriptive analyses were conducted for cycles registered during 2019.ResultsIn 2019, 458 101 treatment cycles and 60 598 neonates were reported, both of which increased from 2018. The number of fresh cycles, including in vitro fertilization and intracytoplasmic sperm injection, decreased, while frozen‐thawed embryo transfer (ET) cycles increased. The mean maternal age was 37.9 years (standard deviation ± 4.7). Of 239 348 oocyte retrievals, 123 690 (51.7%) involved freeze‐all‐embryos cycles; fresh ET was performed in 41 831 cycles (a decreasing trend since 2015). In 2019, there were 211 597 frozen‐thawed ET cycles, resulting in 74 882 pregnancies and 54 168 neonates born. Single ET was performed in 82.6% of fresh transfers and 85.1% of frozen‐thawed cycles, with singleton live birth rates of 97.3% for both.ConclusionsThe number of fresh cycles decreased but frozen cycles increased in 2019. Single ET was performed in >80% of cases, and the proportion of babies born from frozen‐thawed ET increased.
Large deviations of the greedy independent set algorithm on sparse random graphs
Authors: Kolesnik Brett 
Published: December 2021

AbstractWe study the greedy independent set algorithm on sparse Erdős–Rényi random graphs . A large deviation principle was recently established by Bermolen et al. in 2020, however, the proof and rate function are somewhat involved. Upper bounds for the rate function were obtained earlier by Pittel in 1982. Using discrete calculus, we identify the optimal trajectory realizing a given large deviation and obtain the rate function in a simple closed form. In particular, we show that Pittel's bounds are sharp. The proof is brief and elementary. We think the methods presented here will be useful in analyzing the tail behavior of other random processes.
Strategic placement of urban agriculture: A spatial optimization approach
Authors: Thapa Bhuwan , Banerjee Aniruddha , Wilson Jeffrey , Hamlin Samantha 
Published: December 2021

AbstractStrategic placement of urban agriculture such as community gardens can expand alternate food supply, support physical activity, and promote social interactions. While social and health benefits are critical priorities when planning new urban agriculture locations, no widely accepted site selection methods have been established. We developed a spatial optimization model to identify new urban agriculture locations in the City of Indianapolis, Marion County, Indiana. Considering block groups with vacant parcels as potential locations, the study uses p‐median optimization to identify the 25 best locations that would minimize travel from any block group in the city to potential garden locations. We weighted each block group based on food access and prevalence of obesity, where food access was characterized on three dimensions: economic, geographical, and informational. The model was simulated for three policy scenarios with equal, stakeholder‐driven, and obesity‐driven weights, and the results were compared with randomly selected locations. We found that optimally selected locations were 52% more efficient than randomly chosen locations in terms of the average distance traveled by residents based on the p‐median solution. However, there was no significant difference in travel distance among the three policy scenarios. The spatial optimization model can help policymakers and practitioners strategically locate urban agriculture sites.
Causes of long-term mortality in patients with head and neck squamous cell carcinomas
Authors: Lop Joan , Venegas María del Prado , Pujol Albert , Sauter Blanca , Vásquez Rosselin , Casasayas María , Quer Miquel , León Xavier 
Published: December 2021

Abstract
Purpose
After treatment of a head and neck squamous cell carcinoma (HNSCC), patients with an adequate control of the tumor have a decreased overall survival when compared to age- and gender-matched controls in the general population. The aim of our study was to analyze the causes of long-term mortality in patients with HNSCC.

Methods
We carried out a retrospective study of 5122 patients with an index HNSCC treated at our center between 1985 and 2018. We analyzed the survival considering three causes of death: mortality associated with the HNSCC index tumor, mortality associated with a second or successive neoplasm, and mortality associated with a non-cancer cause.

Results
After the diagnosis of an HNSCC the most frequent cause of death is the head and neck tumor itself during the first 3.5 years of follow-up. Thereafter, mortality is more frequently associated with competing causes of death, such as second malignancies and non-cancer causes. Mortality associated with second and successive neoplasms was 2.3% per year, a percentage that was maintained constant throughout the follow-up. Likewise, mortality attributable to non-cancer causes was 1.6% per year, which also remained constant. There were differences in the mortality patterns according to the characteristics of the patients.

Conclusion
There are differences in the mortality patterns of patients with HNSCC depending on their characteristics. Knowledge of these patterns can help in the design of guidelines to improve the follow-up protocols of this group of patients to optimize the clinical cost-effectiveness.
Office-Work-and-Stretch-Training-Studie – die OST-Studie: Gerätegestütztes Dehntraining als Präventionsmaßnahme bei Büroangestellten – eine Zusammenfassung der Studienresultate
Authors: Holzgreve Fabian , Fraeulin Laura , Haenel Jasmin , Schmidt Helmut , Bader Andreas , Frei Markus , Groneberg David A. , Ohlendorf Daniela , van Mark Anke 
Published: December 2021

ZusammenfassungHintergrundDehntrainings sind eine Maßnahme der betrieblichen Gesundheitsförderung (BGF) für Büroangestellte zur Prävention von muskuloskeletalen Erkrankungen (MSE). Sie können zu Beweglichkeitszuwächsen führen und auf psychischer Ebene entspannen. Ziel der Studie war es, ein standardisiertes und individualisiertes Dehntraining am Gerät, das „five-Business“, auf MSE, Lebensqualität und Beweglichkeit zu untersuchen. Dies ist eine Zusammenfassung der international publizierten Ergebnisse.MethodikIn diese Untersuchung wurden 252 Proband(innen) eingeschlossen, 156 in die Interventionsgruppe (IG), 96 in die Kontrollgruppe (KG). Die IG absolvierte für 12 Wochen 22–24 Trainingseinheiten am „five-Business“, möglichst zweimal wöchentlich. Die Datenerhebung erfolgte mittels sportmotorischer bzw. Range-of-motion(ROM)-Tests, dem Nordic Questionnaire (NQ) und dem SF-36-Fragebogen in Form einer Prä-Post-Untersuchung.ErgebnisseNach der Intervention gaben im NQ signifikant weniger Proband(innen) der IG Beschwerden im oberen Rücken (p < 0,001) im Vergleich zur KG an; keine signifikanten Unterschiede wurden bei Beschwerden im Nacken, Schultern, Hüfte und dem unteren Rücken gefunden. Der mit dem SF-36 erhobene allgemeine Gesundheitszustand und die gesundheitsbezogene Lebensqualität haben sich (nach subjektiven Angaben) signifikant verbessert (Summenscore IG:p = 0,005). In den ROM-Tests waren die Prä-Post-Differenzen bei IG-Proband(innen) in der Sagittalebene (Finger-Boden-Abstand und Retroflexion;p < 0,001) und im modifizierten Schultertest nach Janda auf der linken Seite (p = 0,003) signifikant größer.DiskussionTrotz des in Zeitdauer und Häufigkeit relativ geringen Trainingsaufwandes wurden sowohl auf körperlicher als auch auf psychischer Ebene relevante Verbesserungen erzielt, so dass das „five-Business“-Dehntraining als BGF-Maßnahme empfohlen werden kann.
Definiteness in Laki: Its interaction with demonstratives and number
Authors: Taghipour Sahar 
Published: December 2021

AbstractThis article investigates definiteness and its interactions with demonstratives and number in Laki (Northwestern Iranian). By the examination of demonstratives and building upon previous proposals, I argue for two types of definite DPs in Laki, namely anaphoric and deictic. I show that the patterns of definite and number marking are sensitive to the type of the DP. In particular, I argue that double definiteness, resulting from an Agree relation between D and N, and head movement of Num to D both are obtained only in anaphoric definite DPs for feature-checking requirements. Overall, this study highlights the contributions of anaphoricity to the DP internal structure. The present proposal can account for similar phenomena in other Iranian languages (i.e., Sorani and Kermanshahi Kurdish). The divergence of Laki definiteness from similar attested patterns (i.e., Scandinavian double definiteness) contributes to our cross-linguistic understanding of definiteness and its interactions with other nominal elements.
Large deviation principle for piecewise monotonic maps with density of periodic measures
Authors: CHUNG YONG MOO , YAMAMOTO KENICHIRO 
Published: December 2021

AbstractWe show that a piecewise monotonic map with positive topological entropy satisfies the level-2 large deviation principle with respect to the unique measure of maximal entropy under the conditions that the corresponding Markov diagram is irreducible and that the periodic measures of the map are dense in the set of ergodic measures. This result can apply to a broad class of piecewise monotonic maps, such as monotonic mod one transformations and piecewise monotonic maps with two monotonic pieces.
Improving physical distancing among healthcare workers in a pediatric intensive care unit
Authors: Sick-Samuels Anna C. , Cosgrove Sara , Rock Clare , Salinas Alejandra , Oladapo-Shittu Opeyemi , Gurses Ayse P. , Vecchio-Pagan Briana , Osei Patience , Hsu Yea-Jen , Jacak Ron , Zudock Kristina K. , Blount Kianna M. , Bowden Kenneth V. , Keller Sara ,   for the Centers for Disease Control and Prevention Epicenter Program
Published: December 2021

AbstractBackground:Healthcare workers (HCWs) not adhering to physical distancing recommendations is a risk factor for acquisition of severe acute respiratory coronavirus virus 2 (SARS-CoV-2). The study objective was to assess the impact of interventions to improve HCW physical distancing on actual distance between HCWs in a real-life setting.Methods:HCWs voluntarily wore proximity beacons to measure the number and intensity of physical distancing interactions between each other in a pediatric intensive care unit. We compared interactions before and after implementing a bundle of interventions including changes to the layout of workstations, cognitive aids, and individual feedback from wearable proximity beacons.Results:Overall, we recorded 10,788 interactions within 6 feet (∼2 m) and lasting >5 seconds. The number of HCWs wearing beacons fluctuated daily and increased over the study period. On average, 13 beacons were worn daily (32% of possible staff; range, 2–32 per day). We recorded 3,218 interactions before the interventions and 7,570 interactions after the interventions began. Using regression analysis accounting for the maximum number of potential interactions if all staff had worn beacons on a given day, there was a 1% decline in the number of interactions per possible interactions in the postintervention period (incident rate ratio, 0.99; 95% confidence interval, 0.98–1.00; P = .02) with fewer interactions occurring at nursing stations, in workrooms and during morning rounds.Conclusions:Using quantitative data from wearable proximity beacons, we found an overall small decline in interactions within 6 feet between HCWs in a busy intensive care unit after a multifaceted bundle of interventions was implemented to improve physical distancing.
Changes in children’s attachment security to mother and father after the birth of a sibling: Risk and resilience in the family
Authors: Volling Brenda L. , Oh Wonjung , Gonzalez Richard , Bader Lauren R. , Tan Lin , Rosenberg Lauren 
Published: December 2021

AbstractChanges in children’s attachment security to mother and father were examined for 230 firstborn children (M = 31.17 months), their mothers and fathers participating in a longitudinal investigation starting in the last trimester of the mothers’ pregnancy and 1, 4, 8, and 12 months after the birth of an infant sibling. Both parents completed the Attachment Q-set at prenatal, 4, and 12 months. Growth mixture models revealed four latent classes in which children’s attachments were (a) both secure with a modest decline to both parents (68.3%); (b) more secure with father than mother with a steep decline for both (12.6%); (c) both insecure with no change (10%); and (d) more secure with mother than father with a modest increase for both (9.1%). Multi-group latent growth curve analyses revealed that parenting and coparenting differed across families. Children had lower externalizing behavior problems in families with two secure attachments than in families with one secure attachment, either to mother or to father, who, in turn, had fewer problems than children with two insecure attachments. Findings underscore the strengths of a family systems framework to understand attachment relationships with multiple caregivers and the family risks and protective factors that covary with children’s behavioral adjustment after the birth of a sibling.
THEOLOGY AND ECONOMY IN THEPOPOL WUJANDTHEOLOGIA INDORUM
Authors: Knowlton Timothy W. 
Published: December 2021

AbstractDrawing on modern ethnography, scholars often characterize ancient Maya religion as “covenants” involving human beings generating merit through ritual activity in order to repay a primordial debt to the gods. However, models based on modern ethnography alone would not allow us to recognize the impact on Maya religions of those Christian discourses of debt and merit that accompanied sixteenth-century colonization. This article attempts to historicize our understanding of indigenous Mesoamerican theologies by examining how early Colonial indigenous language texts describe moral and ritual obligations to the gods in terms of their societies’ economies. The specific case study here compares two contemporaneous sixteenth-century K'iche' Maya texts: thePopol Wujby traditionalist K'iche' elites and theTheologia Indorumby the Dominican friar Domingo de Vico. Comparison of these texts’ use of exchange-related lexicon illustrates that the traditionalist theological discourse of thePopol Wuj, which emphasizes reciprocal obligations between different beings within an ontological hierarchy, came to exist alongside Christian K'iche' discourses with a more mercantile religious language of spiritual debt payment. It is argued that these results have potential implications for our assessment of ethnohistorical sources on indigenous theology from elsewhere throughout Mesoamerica as well.
Clinical outcomes following long versus short cephalomedullary devices for fixation of extracapsular hip fractures: a systematic review and meta-analysis
Authors: Tan Gabriel Kai Yang , Chong Christoph Sheng , Bin Abd Razak Hamid Rahmatullah 
Published: December 2021

AbstractAlthough both long and short cephalomedullary devices (CMDs) are used in the treatment of extracapsular hip fractures, the advantages of either option are subject to debate. This study aims to evaluate the differences in clinical outcomes with long versus short CMDs for extracapsular hip fractures. Studies included must have included subjects with at least 1 year of follow-up and reported on at least one of the following outcomes: rate of reoperation; rate of peri-implant fracture; operating time; blood loss; complication rate; length of hospital stay; 1-year mortality. Only articles written in the English language were included in this study. A search was conducted across the databases of Medline, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), CINAHL and Scopus for articles published from the inception of the database to 1 November 2020. Included studies were assessed for their risk of bias using the Risk of Bias Tool (RoB2) and the risk-of-bias in non-randomized studies – of interventions (ROBINS-I) tool. A total of 8460 fractures from 16 studies were included in the analysis, with 3690 fixed with short, and 4770 fixed with long CMDs. A meta-analysis of the results revealed that short CMDs offer peri-operative advantages, while long CMDs could offer longer-term advantages. Limitations of this study include a lack of randomized control trials included in the analysis. In conclusion, when planning for the treatment of extracapsular hip fractures, a patient specific approach may be necessary to make a decision according to the individual risk profile of the patient.
The distinct effects of P18 overexpression on different stages of hematopoiesis involve TGF-β and NF-κB signaling
Authors: Yi Danying , Zhu Lijiao , Liu Yuanling , Zeng Jiahui , Chang Jing , Sun Wencui , Teng Jiawen , Zhang Yonggang , Dong Yong , Pan Xu , Chen Yijin , Zhou Ya , Lai Mowen , Zhou Qiongxiu , Liu Jiaxin , Chen Bo , Ma Feng 
Published: December 2021

AbstractDeficiency of P18 can significantly improve the self-renewal potential of hematopoietic stem cells (HSC) and the success of long-term engraftment. However, the effects of P18 overexpression, which is involved in the inhibitory effects of RUNX1b at the early stage of hematopoiesis, have not been examined in detail. In this study, we established inducible P18/hESC lines and monitored the effects of P18 overexpression on hematopoietic differentiation. Induction of P18 from day 0 (D0) dramatically decreased production of CD34highCD43− cells and derivative populations, but not that of CD34lowCD43− cells, changed the cell cycle status and apoptosis of KDR+ cells and downregulated the key hematopoietic genes at D4, which might cause the severe blockage of hematopoietic differentiation at the early stage. By contrast, induction of P18 from D10 dramatically increased production of classic hematopoietic populations and changed the cell cycle status and apoptosis of CD45+ cells at D14. These effects can be counteracted by inhibition of TGF-β or NF-κB signaling respectively. This is the first evidence that P18 promotes hematopoiesis, a rare property among cyclin-dependent kinase inhibitors (CKIs).
Identification of potential core genes in colorectal carcinoma and key genes in colorectal cancer liver metastasis using bioinformatics analysis
Authors: Niu Lipeng , Gao Ce , Li Yang 
Published: December 2021

AbstractColorectal carcinoma (CRC) is one of the most prevalent malignant tumors worldwide. Meanwhile, the majority of CRC related deaths results from liver metastasis. Gene expression profile of CRC patients with liver Metastasis was identified using 4 datasets. The data was analyzed using GEO2R tool. GO and KEGG pathway analysis were performed. PPI network of the DEGs between 1 and 2 gene sets was also constructed. The set 1 is named between primary CRC tissues and metastatic CRC tissues. The set 2 is named between primary CRC tissues and normal tissues. Finally, the prognostic value of hub genes was also analyzed. 35 DEGs (set 1) and 142 DEGs (set 2) were identified between CRC liver metastatic cancer patients. The PPI network was constructed using the top 10 set 1 hub genes which included AHSG, SERPINC1, FGA, F2, CP, ITIH2, APOA2, HPX, PLG, HRG and set 2 hub genes which included TIMP1, CXCL1, COL1A2, MMP1, AURKA, UBE2C, CXCL12, TOP2A, ALDH1A1 and PRKACB. Therefore, ITIH2 might represent the potential core gene for colon cancer liver metastasis. COL1A2 behaves as a key gene in colorectal carcinoma.
The effect of nitrogen species on the catalytic properties of N-doped graphene
Authors: Skorupska Malgorzata , Ilnicka Anna , Lukaszewicz Jerzy P. 
Published: December 2021

AbstractThe production of effective catalysts in the oxygen reduction reaction (ORR) continues to be a great challenge for scientists. A constant increase in demand for energy storage materials is followed by a proportionate increase in the number of reports on electrocatalyst synthesis. The scientific world focuses on environmentally friendly materials synthesized in accordance with the safest possible. In this work, we developed a facile method of obtaining heavy-metal-free electrode materials that are effective in ORR. Graphene-based catalysts were doped using azodicarbonamide (ADC) as the source of nitrogen, then carbonized at high temperatures in the range of 700–900 °C under inert gas flow. The produced materials were tested as catalysts for ORR, which is the most important reaction for Zn–air batteries and fuel cells. All obtained nitrogen-doped graphene foams showed increased catalytic activity in ORR owing to active sites created by nitrogen functional groups on the graphene surface. This paper shows that carbonization temperature has a significant impact on nitrogen content and that a small percentage of nitrogen may have a positive effect on the catalytic activity of the obtained materials. The number of transferred electrons in ORR was found to range from three to the maximal theoretical value, i.e., four.
Real-life prevalence of progressive fibrosing interstitial lung diseases
Authors: Gagliardi Maureen , Berg Damienne Vande , Heylen Charles-Edouard , Koenig Sandra , Hoton Delphine , Tamirou Farah , Pieters Thierry , Ghaye Benoit , Froidure Antoine 
Published: December 2021

AbstractThe concept of progressive fibrosing interstitial lung disease (PF-ILD) has recently emerged. However, real-life proportion of PF-ILDs outside IPF is still hard to evaluate. Therefore, we sought to estimate the proportion of PF-ILD in our ILD cohort. We also determined the proportion of ILD subtypes within PF-ILD and investigated factors associated with PF-ILDs. Finally, we quantified interobserver agreement between radiologists for the assessment of fibrosis. We reviewed the files of ILD patients discussed in multidisciplinary discussion between January 1st 2017 and December 31st 2019. Clinical data, pulmonary function tests (PFTs) and high-resolution computed tomography (HRCTs) were centrally reviewed. Fibrosis was defined as the presence of traction bronchiectasis, reticulations with/out honeycombing. Progression was defined as a relative forced vital capacity (FVC) decline of ≥ 10% in ≤ 24 months or 5% < FVC decline < 10% and progression of fibrosis on HRCT in ≤ 24 months. 464 consecutive ILD patients were included. 105 had a diagnosis of IPF (23%). Most frequent non-IPF ILD were connective tissue disease (CTD)-associated ILD (22%), hypersensitivity pneumonitis (13%), unclassifiable ILD (10%) and sarcoidosis (8%). Features of fibrosis were common (82% of CTD-ILD, 81% of HP, 95% of uILD). After review of HRCTs and PFTs, 68 patients (19% of non-IPF ILD) had a PF-ILD according to our criteria. Interobserver agreement for fibrosis between radiologists was excellent (Cohen’s kappa 0.86). The main diagnosis among PF-ILD were CTD-ILD (36%), HP (22%) and uILD (20%). PF-ILD patients were significantly older than non-F-ILD (P = 0.0005). PF-ILDs represent about 20% of ILDs outside IPF. This provides an estimation of the proportion of patients who might benefit from antifibrotics. Interobserver agreement between radiologists for the diagnosis of fibrotic ILD is excellent.