bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peroral endoscopic myotomy for management of cricopharyngeal bars (CP-POEM): a retrospective evaluation
Authors: Al Ghamdi Sarah S. , Bejjani Michael , Hernández Mondragón Oscar V. , Parsa Nasim , Yousaf Muhammad N. , Aghaie Meybodi Mohammad , Ghandour Bachir , Krustri Chonlada , Phalanusitthepha Chainarong , Ngamruengphong Saowanee , Nieto Jose M. , Khashab Mouen A. 
Published: October 2021

Abstract
Background Cricopharyngeal bars (CPBs) are a unique etiology of oropharyngeal dysphagia. Symptomatic patients are managed with endoscopic dilation or surgical myotomy. Cricopharyngeal peroral endoscopic myotomy (CP-POEM) is an emerging technique for the management of dysphagia due to CPBs. This study evaluated technical success, clinical success, adverse events, and long-term recurrence following CP-POEM.
Methods Consecutive patients who underwent POEM for management of CPBs between May 2015 and December 2020 at four tertiary care centers were included. Primary outcome was clinical success (defined as improvement of dysphagia score to ≤ 1). Secondary outcomes were technical success, rate and severity of adverse events, procedure duration, and symptom recurrence.
Results 27 patients (mean age 69 years; 10 female) underwent CP-POEM during the study period. The most common presenting symptoms at the time of index procedure were dysphagia (26; 96.3 %) and regurgitation (20; 74.1 %). Clinical and technical success were achieved in all patients. Mild/moderate adverse events occurred in two patients (7.4 %). CP-POEM significantly reduced the median dysphagia score.
Conclusions CP-POEM was a safe and effective treatment for symptomatic CPBs. Although symptom recurrence was low, long-term outcome data are needed. CP-POEM should be considered as a management option for symptomatic CPBs at centers with POEM expertise.
Functionalized Bipyrroles and Pyrrolyl-Aminopyrones from Acylethynylpyrroles and Diethyl Aminomalonate
Authors: Trofimov Boris A. , Gotsko Maxim D. , Saliy Ivan V. , Sobenina Lyubov N. , Ushakov Igor A. , Kireeva Victoriya V. 
Published: October 2021

AbstractAn efficient method for the synthesis of 1H,1′H-2,3′-bi­pyrroles (up to 72% yield) by the cyclocondensation of easily available 2-(acylethynyl)pyrroles with diethyl aminomalonate hydrochloride has been developed. The reaction proceeds under reflux in MeCN (6 h) in the presence of Cs2CO3. Under the same conditions, 2-(acylethynyl)pyrroles with bulky (benzyl and octyl) substituents at nitrogen atom react with diethyl aminomalonate to afford 1H,2′H-2,3′-bipyrroles and pyrrolyl-aminopyrones.
1,3-Bis(trifluoromethyl)prop-2-ene 1-Iminium Salts: Reactions with Alkoxybenzenes and Anilines
Authors: Maas Gerhard , Keim Michael , Jasarevic Medina , Miller Ines 
Published: October 2021

Abstract1,3-Bis(trifluoromethyl)prop-2-ene 1-iminium triflate salts were prepared for the first time and some synthetic applications as 1,3-biselectrophilic building blocks were established. They were found to react with dimethoxybenzenes or methylene-1,2-dioxybenzenes to furnish vinylogous trifluoroacetylation products (4-aryl-1,1,1,5,5,5-hexafluoropent-3-en-2-ones) and 1-dialkylamino-1,3-bis(trifluoromethyl)-1H-indenes. With aniline and ring-substituted anilines, 2,4-bis(trifluoromethyl)quinolines were formed. An unusual 4H-pyran, formally a condensation product of the N,N-dimethyl-1,3-bis(trifluoromethyl)prop-2-en-1-iminium ion and its enaminone precursor, is also reported.
Combined Antiplatelet Therapy Reduces the Proinflammatory Properties of Activated Platelets
Authors: Heinzmann Alexandra C.A. , Coenen Daniëlle M. , Vajen Tanja , Cosemans Judith M.E.M. , Koenen Rory R. 
Published: October 2021

AbstractThe cause of atherothrombosis is rupture or erosion of atherosclerotic lesions, leading to an increased risk of myocardial infarction or stroke. Here, platelet activation plays a major role, leading to the release of bioactive molecules, for example, chemokines and coagulation factors, and to platelet clot formation. Several antiplatelet therapies have been developed for secondary prevention of cardiovascular events, in which anticoagulant drugs are often combined. Besides playing a role in hemostasis, platelets are also involved in inflammation. However, it is unclear whether current antiplatelet therapies also affect platelet immune functions. In this study, the possible anti-inflammatory effects of antiplatelet medications on chemokine release were investigated using enzyme-linked immunosorbent assay and on the chemotaxis of THP-1 cells toward platelet releasates. We found that antiplatelet medication acetylsalicylic acid (ASA) led to reduced chemokine (CC motif) ligand 5 (CCL5) and chemokine (CXC motif) ligand 4 (CXCL4) release from platelets, while leukocyte chemotaxis was not affected. Depending on the agonist, αIIbβ3 and P2Y12 inhibitors also affected CCL5 or CXCL4 release. The combination of ASA with a P2Y12 inhibitor or a phosphodiesterase (PDE) inhibitor did not lead to an additive reduction in CCL5 or CXCL4 release. Interestingly, these combinations did reduce leukocyte chemotaxis. This study provides evidence that combined therapy of ASA and a P2Y12 or PDE3 inhibitor can decrease the inflammatory leukocyte recruiting potential of the releasate of activated platelets.
Transferência do grande dorsal para lesões anterossuperiores irreparáveis do manguito rotador: descrição de técnica cirúrgica
Authors: Simionato Ivan Fadanelli , Matsumoto Fábio Yoshihiro , Britto Almiro Gerszon , Ferreira Marco Tonding , Eichenberg Augusto Heinen , Mothes Fernando Carlos 
Published: October 2021

ResumoAs lesões do manguito rotador do ombro podem ter diversas configurações, e são divididas e/ou classificadas conforme o tamanho da lesão, o tendão envolvido, suas combinações, e se existe a possibilidade de reparo. As lesões irreparáveis do subescapular, assim como as lesões irreparáveis anterossuperiores, podem gerar disfunção do ombro devido à perda dos depressores da cabeça umeral, o que causa dor e limitação funcional. Entre as alternativas terapêuticas estão as transferências miotendíneas, sendo a técnica de transferência do peitoral maior para a tuberosidade menor a mais estudada e difundida nas últimas décadas. No entanto, alguns estudos anatômicos sugerem que o grande dorsal seja uma alternativa mais adequada para o tratamento dessas lesões por apresentar vetores de força mais parecidos com os do subescapular, além de apresentar resultados promissores nas avaliações clínicas de curto seguimento. Este trabalho tem o objetivo de descrever a técnica cirúrgica desenvolvida para transferência do grande dorsal nas lesões irreparáveis do subescapular e anterossuperiores do manguito rotador.
Prevalência e fatores associados à dor e ao histórico de lesões musculoesqueléticas em skatistas
Authors: Ferreira Bruna Dias Alves , Marques Joyce de Jesus , Santos Thiago Ribeiro Teles 
Published: October 2021

Resumo
Objetivo (a) Identificar a prevalência de dor musculoesquelética atual e lesão no último ano e (b) verificar a associação da presença de dor atual e da história de lesão com características demográficas, da prática esportiva e da saúde em skatistas.
Método O presente estudo observacional transversal foi realizado com 64 skatistas que responderam a um questionário abordando características demográficas, da prática esportiva e da saúde. O teste exato de Fisher verificou a associação dessas características com a presença de dor atual e com o relato de lesão no último ano. O teste de qui-quadrado verificou se havia diferença entre a distribuição observada e a esperada para o segmento corporal relatado com dor e com histórico de lesão, e com o tipo de lesão.
Resultados A prevalência de dor foi de 82,8%, sendo a frequência observada maior do que a esperada (p < 0,01) no joelho, no tornozelo, na região lombossacra e no pé. A presença de dor foi associada à faixa etária (p = 0,05) e a tratamento fisioterápico prévio (p < 0,01). A prevalência de lesão no último ano foi de 68,8%, sendo a frequência observada maior do que a esperada (p < 0,01) no joelho, no tornozelo, no punho, na mão, no pé e no ombro. Entorse e fratura apresentaram uma frequência observada maior do que a esperada (p < 0,01). O histórico de lesão foi associado ao uso de equipamento de proteção (p = 0,01), cirurgia prévia (p = 0,02) e tratamento fisioterápico (p = 0,03).
Conclusão A prática de skate apresenta uma prevalência alta de dor e de lesões no último ano. Os achados podem contribuir com o planejamento de estratégias preventivas.
Aplicação do adesivo de lidocaína 5% em cicatrizes cirúrgicas dolorosas: Ensaio clínico
Authors: Macedo Rafael da Rocha , Santos João Paulo Gonçalves dos , Lobato Emanuel Smith , Mendes João Pereira , Ikemoto Roberto Yukio , Rodrigues Luciano Miller Reis 
Published: October 2021

Resumo
Objetivo Avaliar o emplastro de lidocaína 5% como método de tratamento da dor neuropática após cirurgias ortopédicas em comparação com massagem terapêutica realizada sobre incisões.
Métodos Trata-se de um ensaio clínico prospectivo, randomizado, com 37 pacientes submetidos a cirurgia ortopédica entre janeiro de 2015 e fevereiro de 2017. Foram incluídos pacientes com idade entre 13 e 70 anos que foram submetidos a cirurgia ortopédica no pé e tornozelo com dor neuropática ou hipersensibilidade na incisão cirúrgica por no mínimo 90 dias após o procedimento. Todos os indivíduos foram avaliados segundo a escala visual analógica (EVA) de dor e o questionário de qualidade de vida SF-36 no início do tratamento e após 30, 60 e 90 dias.
Resultados Os dois grupos apresentaram melhora da dor; porém, o grupo que utilizou o emplastro apresentou maior redução com o passar do tempo. Em relação aos parâmetros do questionário SF-36, nenhum deles demonstrou diferença estatisticamente relevante. Em relação à capacidade funcional, aos aspectos físicos, à vitalidade, aos aspectos emocionais, aos aspectos sociais, ao estado geral de saúde e saúde mental, não houve evidências significativas. A grande vantagem do emplastro está no grau de satisfação pessoal dos pacientes, com relevância estatística, provavelmente pela facilidade de aplicação e pelo efeito psicológico de uma terapia medicamentosa.
Conclusão O emplastro e a massagem são métodos de tratamento eficazes na redução da dor cicatricial, apresentando resultados semelhantes. O emplastro está associado à melhora do grau de satisfação dos pacientes. Nível de Evidência 1. Ensaio clínico prospectivo randomizado.
Fatores associados ao desenvolvimento de complicações precoces após artroplastia total do joelho
Authors: Tavares Matheus Rizério , Alencar Savio Diego Ribeiro de , Frazão Samir Peixoto , Azi Matheus Lemos , Sadgursky David , Alencar Daniel 
Published: October 2021

Resumo
Objetivo Identificar fatores de risco para o desenvolvimento de complicações pós-operatórias locais ou clínicas ocorridas até 30 dias após a cirurgia em pacientes submetidos a artroplastia total do joelho.
Métodos Todos os pacientes submetidos a artroplastia de joelho realizada neste hospital no período do estudo foram incluídos na análise, baseada em dados dos prontuários dos pacientes, para investigar os fatores associados à ocorrência de complicações locais ou clínicas durante o internamento até 30 dias após o procedimento que necessitaram de alguma intervenção.
Resultados Dos 157 pacientes incluídos no estudo, 17,1% cursaram com alguma complicação. As mais prevalentes foram artrofibrose (6,4%), infecção profunda (4,4%) e infecção superficial (2,5%), dentre outras. A maior idade e maior número de comorbidades prévias foram relacionadas com maior risco de complicações pós-operatórias.
Conclusões A maior idade e maior número de comorbidades foram relacionados a um risco aumentado de complicações pós-operatórias. O escore Sociedade Americana de Anestesiologistas (ASA, na sigla em inglês) se mostrou insuficiente para avaliar a ocorrência de complicações pós artroplastia de joelho e novas ferramentas devem ser empregadas para este fim.
Genetic Variants in the Protein S (PROS1) Gene and Protein S Deficiency in a Danish Population
Authors: Larsen Ole Halfdan , Kjaergaard Alisa D. , Hvas Anne-Mette , Nissen Peter H. 
Published: October 2021

AbstractProtein S (PS) deficiency is a risk factor for venous thromboembolism (VTE) and can be caused by variants of the gene encoding PS (PROS1). This study aimed to evaluate the clinical value of molecular analysis of the PROS1 gene in PS-deficient participants. We performed Sanger sequencing of the coding region of the PROS1 gene and multiplex ligation-dependent probe amplification to exclude large structural rearrangements. Free PS was measured by a particle-enhanced immunoassay, while PS activity was assessed by a clotting method.A total of 87 PS-deficient participants and family members were included. In 22 index participants, we identified 13 PROS1 coding variants. Five variants were novel. In 21 index participants, no coding sequence variants or structural rearrangements were identified. The free PS level was lower in index participants carrying a PROS1 variant compared with index participants with no variant (0.51 [0.32–0.61] vs. 0.62 [0.57–0.73] × 103 IU/L; p < 0.05). The p.(Thr78Met) variant was associated with only slightly decreased free PS levels (0.59 [0.53–0.66] × 103 IU/L) compared with the p.(Glu390Lys) variant (0.27 [0.24–0.37] × 103 IU/L, p < 0.01). The frequency of VTE in participants with a coding PROS1 variant was 43 and 17% in the group with normal PROS1 gene (p = 0.05).In conclusion, we report 13 PROS1 coding variants including five novel variants. PS levels differ by PROS1 variant and the frequency of VTE was higher when a coding PROS1 variant was present. Hence, molecular analysis of the PROS1 gene may add clinical value in the diagnostic work-up of PS deficiency.
Introducing a global planetary ecosystem accounting in the wake of the Amazon Forest fires
Authors: Allam Zaheer , Jones David S. , Biyik Can 
Published: October 2021

AbstractSince the 19th century, rapid urbanisation coupled with a demographic boom has increased pressures on the global exploitation of natural resources leading to an array of issues at planetary scale. Even though there have been significant ecologically driven human policy efforts, with frameworks addressing ecosystem accounting and management, such are principally constricted at sub-global levels; being regionally focussed, and hence lacking both cohesivity and accountability. Resource management viewed through this lens leads to a number of geopolitical factors as demonstrated recently with the Amazon Forest fires. This incident witnessed calls from numerous countries calling for rapid remediation even though their own policies are harbingers of equally damaging the environments through other means. This disparity in resource accounting and management on a planetary scale is apparent from diverse local and regional groups and needs to be addressed in order to sustain a truly sustainable and liveable ecosystem and their failures in realising a viable ecosystem accounting system. This perspective paper explores this theme and proposes a ‘Global Planetary Ecosystem Accounting’ system based on the principle that ecologically sensitive areas benefiting the global ecosystem need to be economically weighted and its preservation equated to a revenue-generating activity.
Figure Composition
Authors: Zuckerman Charles H. P. 
Published: October 2021

AbstractLinguistic anthropologists have shown that the way a person reports speech or represents discourse—for example, whether they ‘put on an accent’ or merely repeat attributed words—is crucial for understanding what social action that person is undertaking. And yet, our tools for talking about the form of represented discourse are still crude. This paper offers a new tool in the notion of figure composition, defined as the formal semiotic elements that comprise a given voice. Reflecting on figure composition, alongside Agha’s (2005) notion of figure transparency, invites us to shift from asking what kind of represented discourse any given stretch of represented discourse is to asking (1) What elements of represented discourse appear to be coming from the quoted figure(s)? and (2) How are these elements used to produce interactional effects?
Discursive Registers in Finno-Karelian Communicative Incantations
Authors: Karlsson Tuukka 
Published: October 2021

AbstractThe present paper investigates discursive justification as a moderative device in Kalevala-metric incantations. It explores different uses of justification by Finno-Karelian ritual specialists and argues that justification functions differently with positively and negatively evaluated non-human agents. In addition, a typology of discursive units of justification is provided. The results of the analysis reveal that justification functions as a register-based feature within the incantation genre. Types of justification directed to differently evaluated agents work as register-emblematic features. These findings open up new directions in the research of registers in Kalevala-metric incantation genre as constituted of multiple registers of communication.
APMP key comparison of absorbed dose to water for 60Co, APMP.RI(I)-K4
Authors: Lin Y C , Lee J H , Butler D , Webb D , Krauss A , Kurosawa T , Morishita Y , Bero M , Vinatha S P , Budiantari C T , Srimanoroth S , Chun K J , Wang K , Khaled N E , Kadni T B , Msimang Z , Laban J 
Published: October 2021

Main text
The APMP/TCRI Dosimetry Working Group performed the APMP.RI(I)-K4 key comparison of absorbed dose to water for 60Co between 2009 and 2010. Fourteen standards laboratories took part in the comparison. Three commercial cavity ionization chambers were used as transfer instruments and circulated among the participants. Nearly all the measured calibration coefficients for each ionization chamber were within one standard uncertainty (as estimated by the laboratory) of the comparison mean for that chamber, indicating reasonable agreement amongst the participants. Three participants (ARPANSA, PTB and NMIJ) were used to link the results to the BIPM through the ongoing bilateral BIPM.RI(I)-K4 comparison. Through this link the degree of equivalence (the ratio to the BIPM Key Comparison Reference Value and its uncertainty) was calculated for each non-linking laboratory to show the calibration capabilities. For the 9 eligible participants, this degree of equivalent ratio fell within 3.3 parts in 103 of unity, well within the combined standard uncertainty in all cases.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Determination of a spatial load in a damped Kirchhoff–Love plate equation from final time measured data
Authors: Anjuna D , Sakthivel K , Hasanov A 
Published: October 2021

Abstract
In this paper, we study the inverse problem of determining an unknown spatial load F(x) in the damped non-homogeneous isotropic rectangular Kirchhoff–Love plate equation

ρ

h

(

x

)

u

t
t

+
μ

(

x

)

u

t

+

D

(

x

)

(

u

x

1

x

1

+
ν

u

x

2

x

2

)

x

1

x

1

+

D

(

x

)

(

u

x

2

x

2

+
ν

u

x

1

x

1

)

x

2

x

2

+
2

(

1
−
ν

)

D

(

x

)

u

x

1

x

2

x

1

x

2

=
F

(

x

)

G

(

t

)

,

(

x
,
t

)

∈
Ω
×

0
,
T

from final time measurement data u

T
(x) = u(x, T). Using the quasi-solution approach, the inverse problem is posed as a least square minimization problem of the Tikhonov functional, and the existence of minimum is shown. We prove that this functional is Fréchet differentiable and the derivative is written in terms of an adjoint problem associated with the Kirchhoff–Love plate equation. We establish sufficient conditions on the final time T and a lower bound of the damping parameter μ(x) to derive stability estimates for the determination of F(x) by invoking a first-order necessary optimality condition of the minimization problem. By the method of singular value decomposition of the input–output operator, sufficient conditions on the temporal load G(t) and the singular values are obtained to express the source term as a Fourier series representation of the measured data. We establish a relationship between the representation formulas for the regularized solution F

α
∈ L
2(Ω) obtained by Tikhonov regularization and singular value decomposition methods. A numerical example of reconstructing the spatial load by applying the conjugate gradient algorithm is also presented. In the end, we derive another stability estimate by using the spectral properties of the input–output operator and regularity assumption on G(t).
Structural process and testing of tunneling attitude sensor based on gravity gradient torque measurements
Authors: Yalu Cao , Jiahao Zhao , Fei Xing , Zheng You 
Published: October 2021

Abstract
The function of determining the orientation of a satellite in orbit is known as attitude determination. Depending on the missions, this important function is typically performed by different optical instruments. Due to the limited field of view, multiple optical sensors are placed in all directions to ensure large coverage. A kind of inertial sensor that uses the gravity gradient torque as a reference for attitude determination was proposed recently. At present, the volume of this kind of sensors is large and the accuracy is not high enough. In this paper, we propose an attitude sensor, which is composed of a barbell-shaped sensitive structure with larger moment of inertia and a small displacement detection module based on the tunneling effect. The sensitive structure is fabricated by silicon-on-glass process based on micro-electro-mechanical system technology. As a result, the sensitive structure has a smaller size, and the accuracy of angle measurement can reach 7.3° (3σ) in the range of −20° to +20°.
Beam shifts in two-dimensional atomic crystals
Authors: Ling Xiaohui , Zhang Zan , Chen Shizhen , Zhou Xinxing , Luo Hailu 
Published: October 2021

Abstract
Optical beam shifts, which mainly refer to the Goos–Hänchen shift and spin-Hall shift, widely exist in basic optical processes such as interface reflection and refraction. They are very sensitive to changes in the parameters of the materials that constitute the interface and therefore show great potential for applications in precision metrology and sensing. The interaction between light and two-dimensional (2D) atomic crystals is very weak, and beam shifts provide an alternative approach to explore and characterize 2D atomic crystals. In this paper, we first present a full-wave theory of beam shifts and introduce the experimental measurement of beam displacements with quantum weak measurement technology, and then review their applications in characterizing 2D atomic crystals, such as determining the layer number and measuring the optical conductivity of few-layer graphene. Finally, we discuss the beam displacements in twisted bilayer 2D atomic crystals and 2D atomic crystals under applied electric or magnetic fields.