bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systems‐engineering approach to nation‐scale problems: Municipal solid waste management in Saudi Arabia
Authors: Midgley W. J. B. , Henshaw M. J. de C. , Alshuhri S. 
Published: August 2021

AbstractThe systems‐engineering context of the solid waste disposal problem is discussed with a focus on the issues in Saudi Arabia. A methodology was developed for dividing the system of interest into a set of weakly‐coupled sub‐systems that interact with the narrow system of interest. A model of the narrow system of interest, in this case the municipal solid waste (MSW) system of Saudi Arabia, was then created and validated. The development of this mathematical model is described and is used to investigate a range of scenarios for the future of Saudi Arabia's MSW system with a time horizon of 30 years. The most effective method uses anaerobic digestion, incineration and recycling to reduce the total mass to landfill over the 30 years by 73% when compared to the default scenario (no action taken). In the final year of the simulation, this method reduces the total annual mass to landfill by 69% when compared to a reasonable source reduction strategy. The energy generated by incineration, is shown to contribute a maximum of 2.3% to the Kingdom's annual energy production. Lifecycle analysis shows that the best waste management method produces a DALY (disability life year) score which is 2% of the current strategy, even if moderate source reduction is employed. The two newly suggested scenarios are shown to have a net positive impact on the environment due to the recycling of a large part of the waste stream, preventing acidification/eutrophication due to the manufacture of virgin goods.
Integrable bootstrap for AdS3/CFT2 correlation functions
Authors: Eden Burkhard , le Plat Dennis , Sfondrini Alessandro 
Published: August 2021

Abstract
We propose an integrable bootstrap framework for the computation of correlation functions for superstrings in AdS3 × S3 × T4 backgrounds supported by an arbitrary mixture or Ramond-Ramond and Neveu-Schwarz-Neveu-Schwarz fluxes. The framework extends the “hexagon tessellation” approach which was originally proposed for AdS5 × S5 and for the first time it demonstrates its applicability to other (less supersymmetric) setups. We work out the hexagon form factor for two-particle states, including its dressing factors which follow from those of the spectral problem, and we show that it satisfies non-trivial consistency conditions. We propose a bootstrap principle, slightly different from that of AdS5 × S5, which allows to extend the form factor to arbitrarily many particles. Finally, we compare its predictions with some correlation functions of protected operators. Possible applications of this construction include the study of wrapping corrections, of higher-point correlation functions, and of non-planar corrections.
Infinite-dimensional fermionic symmetry in supersymmetric gauge theories
Authors: Dumitrescu Thomas T. , He Temple , Mitra Prahar , Strominger Andrew 
Published: August 2021

Abstract
We establish the existence of an infinite-dimensional fermionic symmetry in four-dimensional supersymmetric gauge theories by analyzing semiclassical photino dynamics in abelian $$ \mathcal{N} $$
N
= 1 theories with charged matter. The symmetry is parametrized by a spinor-valued function on an asymptotic S2 at null infinity. It is not manifest at the level of the Lagrangian, but acts non-trivially on physical states, and its Ward identity is the soft photino theorem. The infinite-dimensional fermionic symmetry resides in the same $$ \mathcal{N} $$
N
= 1 supermultiplet as the physically non-trivial large gauge symmetries associated with the soft photon theorem.
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells
Authors: Wilmore Sarah , Rogers-Broadway Karly-Rai , Taylor Joe , Lemm Elizabeth , Fell Rachel , Stevenson Freda K. , Forconi Francesco , Steele Andrew J. , Coldwell Mark , Packham Graham , Yeomans Alison 
Published: August 2021

AbstractSignaling via the B-cell receptor (BCR) is a key driver and therapeutic target in chronic lymphocytic leukemia (CLL). BCR stimulation of CLL cells induces expression of eIF4A, an initiation factor important for translation of multiple oncoproteins, and reduces expression of PDCD4, a natural inhibitor of eIF4A, suggesting that eIF4A may be a critical nexus controlling protein expression downstream of the BCR in these cells. We, therefore, investigated the effect of eIF4A inhibitors (eIF4Ai) on BCR-induced responses. We demonstrated that eIF4Ai (silvestrol and rocaglamide A) reduced anti-IgM-induced global mRNA translation in CLL cells and also inhibited accumulation of MYC and MCL1, key drivers of proliferation and survival, respectively, without effects on upstream signaling responses (ERK1/2 and AKT phosphorylation). Analysis of normal naïve and non-switched memory B cells, likely counterparts of the two main subsets of CLL, demonstrated that basal RNA translation was higher in memory B cells, but was similarly increased and susceptible to eIF4Ai-mediated inhibition in both. We probed the fate of MYC mRNA in eIF4Ai-treated CLL cells and found that eIF4Ai caused a profound accumulation of MYC mRNA in anti-IgM treated cells. This was mediated by MYC mRNA stabilization and was not observed for MCL1 mRNA. Following drug wash-out, MYC mRNA levels declined but without substantial MYC protein accumulation, indicating that stabilized MYC mRNA remained blocked from translation. In conclusion, BCR-induced regulation of eIF4A may be a critical signal-dependent nexus for therapeutic attack in CLL and other B-cell malignancies, especially those dependent on MYC and/or MCL1.
Molekulare Diagnostik und Therapie der Epidermolysis bullosa
Authors: Prodinger C. , Klausegger A. , Bauer J. W. , Laimer M. 
Published: August 2021

ZusammenfassungUnter Epidermolysis bullosa (EB) subsumiert man genetische Erkrankungen, die durch gesteigerte Hautfragilität mit Blasenbildung nach bereits geringen mechanischen Belastungen gekennzeichnet sind. Hochvariable kutane, extrakutane und Organmanifestationen verursachen eine signifikante Morbidität und Mortalität sowie eine hohe Krankheitslast für Betroffene und Angehörige. Obwohl derzeit nicht heilbar, eröffnen Fortschritte in der molekularen Charakterisierung pathogenetischer Prozesse, in den diagnostischen Techniken und molekularen Therapieansätzen neue Perspektiven. Neben korrektiven, potenziell kurativen Behandlungszugängen mit dem Ziel der Wiederherstellung der Funktion von Gen bzw. Protein stellen krankheitsmodifizierende Strategien eine wertvolle Ergänzung dar. Unter Letztere fallen symptomatische Therapien, die sekundär dysregulierte, den Phänotyp modulierende Entzündungskaskaden adressieren oder zielgerichtete Interventionen hinsichtlich bestimmter Symptome wie Fibrosierung, Juckreiz oder kanzerogener Zelltransformation. Molekulare Verfahren erlauben heute zudem, eine Diagnose und damit Prognose früher und präziser zu stellen, was die genetische Beratung erleichtert.Das Management von EB-Patienten ist komplex und bedarf einer Spezialexpertise und multidisziplinär akkordierten Versorgung. Entsprechende Ressourcen halten designierte Expertisezentren wie das EB-Haus Austria vor, das als Mitglied des Europäischen Referenznetzwerks für Seltene Hauterkrankungen (ERN Skin) sowohl klinische Versorgung, Grundlagen- und klinische Forschungsaktivitäten sowie Zugang zu Aus- und Weiterbildungsprogrammen für Betroffene, Betreuende und medizinisches Fachpersonal gewährleistet.
How does AirBnb affect local Spanish tourism markets?
Authors: Jiménez Juan Luis , Ortuño Armando , Pérez-Rodríguez Jorge V. 
Published: August 2021

AbstractThis paper analyses the effects of AirBnb on the size of local tourism markets using AirBnb occupancy rates and hotel overnight stays in order to explore the causal relationship in several Spanish cities. A dynamic panel data model is applied at the city level (2014–2017). Our findings show a positive relationship between the increase in the number of properties offered on AirBnb and the implicit volume of tourists received by each city, specifically in two large cities (Madrid and Barcelona), due to higher AirBnb occupancy rate.
Contrasting gut microbiota in captive Eurasian otters (Lutra lutra) by age
Authors: Okamoto Yumiko , Ichinohe Natsumi , Woo Cheolwoon , Han Sung-Yong , Kim Hyeong-Hoo , Ito Sakura , Nakamura Chiho , Kumura Junpei , Nagaoka Kentaro , Yamamoto Naomichi 
Published: August 2021

AbstractUnderstanding the gut microbiota characteristics of endangered species such as the Eurasian otter (Lutra lutra), especially in their early stages of life, could be essential for improving their management and ex situ conservation strategies. Here, we analyzed the gut microbiota diversity, composition, and function of captive Eurasian otters at different ages using high-throughput 16S rRNA gene sequencing. We found that: (1) Clostridiaceae was abundant in all age stages; (2)Lactococcusin cubs is thought to predominate for digesting milk; (3) bacteria associated with amino acid metabolism increase with age, while bacteria associated with carbohydrate metabolism decrease with age, which is likely due to decrease in dietary carbohydrate content (e.g., milk) and increase in dietary protein contents (e.g., fishes) with age; and (4) fish-related bacteria were detected in feces of healthy adults and juveniles. Overall, the gut microbiota of captive Eurasian otters was taxonomically and functionally different by age, which is thought to be attributed to the difference in the diet in their life stages. This study provided baseline information regarding the gut microbiota of Eurasian otters for the first time and contributes to improvement in their management in captivity.
Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro
Authors: Steinritz Dirk , Lüling Robin , Siegert Markus , Mückter Harald , Popp Tanja , Reinemer Peter , Gudermann Thomas , Thiermann Horst , John Harald 
Published: August 2021

AbstractCreatine kinase (CK) catalyzes the formation of phosphocreatine from adenosine triphosphate (ATP) and creatine. The highly reactive free cysteine residue in the active site of the enzyme (Cys283) is considered essential for the enzymatic activity. In previous studies we demonstrated that Cys283 is targeted by the alkylating chemical warfare agent sulfur mustard (SM) yielding a thioether with a hydroxyethylthioethyl (HETE)-moiety. In the present study, the effect of SM on rabbit muscle CK (rmCK) activity was investigated with special focus on the alkylation of Cys283 and of reactive methionine (Met) residues. For investigation of SM-alkylated amino acids in rmCK, micro liquid chromatography-electrospray ionization high-resolution tandem-mass spectrometry measurements were performed using the Orbitrap technology. The treatment of rmCK with SM resulted in a decrease of enzyme activity. However, this decrease did only weakly correlate to the modification of Cys283 but was conclusive for the formation of Met70-HETE and Met179-HETE. In contrast, the activity of mutants of rmCK produced by side-directed mutagenesis that contained substitutions of the respective Met residues (Met70Ala, Met179Leu, and Met70Ala/Met179Leu) was highly resistant against SM. Our results point to a critical role of the surface exposed Met70 and Met179 residues for CK activity.
Bone tissue preservation in seawater environment: a preliminary comparative analysis of bones with different post-mortem histories through anthropological and radiological perspectives
Authors: Bertoglio Barbara , Messina Carmelo , Cappella Annalisa , Maderna Emanuela , Mazzarelli Debora , Lucheschi Stanilla , Sardanelli Francesco , Sconfienza Luca Maria , Sforza Chiarella , Cattaneo Cristina 
Published: August 2021

AbstractBone taphonomy is a widely investigated topic; however, few data are available concerning marine bone taphonomy, especially on remains recovered from great depths and with short post-mortem intervals. To date, few studies have evaluated the bony changes which occur in seawater compared to samples with different post-mortem histories, and none through a comparative analysis of different approaches. To this purpose, this pilot study aims to examine the influence of seawater on bone preservation compared to other depositional contexts by multiple perspectives. Forty-nine human bone samples (femurs or tibiae) recovered from different environments (sea water, fresh water, outdoor, burial in coffin) were compared by macroscopic, microscopic and bone densitometric approaches. In order to investigate organic and inorganic components, undecalcified and decalcified histology of thin sections was performed. The analyses revealed a well-preserved bone tissue both macroscopically (92%) and microscopically (97% and 95% for undecalcified and decalcified sections). No significant differences were detected from radiological densitometric investigations (BMD = 1.6 g/cm2 ± 0.1), except between old and young individuals (p value < 0.001). Differences were observed for body decomposition and few scavenged samples (3/15). However, even if slight variations were observed, no relation was recorded with the depositional contexts. We found a similar bone preservation in the four environments at the time of recovery, both macroscopically and microscopically, but also with radiological densitometric investigations. Our observations enriched the literature on bone taphonomy, providing data on bone tissue preservation in the early post-mortem period from a multidisciplinary perspective, paving the way for further studies on the topic.
Electric signal synchronization as a behavioural strategy to generate social attention in small groups of mormyrid weakly electric fish and a mobile fish robot
Authors: Worm Martin , Landgraf Tim , von der Emde Gerhard 
Published: August 2021

AbstractAfrican weakly electric fish communicate at night by constantly emitting and perceiving brief electrical signals (electric organ discharges, EOD) at variable inter-discharge intervals (IDI). While the waveform of single EODs contains information about the sender’s identity, the variable IDI patterns convey information about its current motivational and behavioural state. Pairs of fish can synchronize their EODs to each other via echo responses, and we have previously formulated a ‘social attention hypothesis’ stating that fish use echo responses to address specific individuals and establish brief dyadic communication frameworks within a group. Here, we employed a mobile fish robot to investigate the behaviour of small groups of up to four Mormyrus rume and characterized the social situations during which synchronizations occurred. An EOD-emitting robot reliably evoked social following behaviour, which was strongest in smaller groups and declined with increasing group size. We did not find significant differences in motor behaviour of M. rume with either an interactive playback (echo response) or a random control playback by the robot. Still, the robot reliably elicited mutual synchronizations with other fish. Synchronizations mostly occurred during relatively close social interactions, usually when the fish that initiated synchronization approached either the robot or another fish from a distance. The results support our social attention hypothesis and suggest that electric signal synchronization might facilitate the exchange of social information during a wide range of social behaviours from aggressive territorial displays to shoaling and even cooperative hunting in some mormyrids.
Oncoplastic breast surgery combining partial mastectomy with resection of double equilateral triangular skin flaps
Authors: Kijima Yuko , Hirata Munetsugu , Higo Naotomo , Toda Hiroko , Shinden Yoshiaki 
Published: August 2021

AbstractThe treatment of early breast cancer using oncoplastic breast surgery (OBS) has been gradually increasing in popularity and is recognized for its efficacy in local control and excellent cosmetic results. We herein report a useful technique for obtaining symmetry of the breast shape for an early breast lesion located in an outer area, close to the nipple-areola, in a Japanese patient with ptotic, fatty breasts. We designed two equilateral triangles: one just upon the resected area and the other on the axilla. They were located on a straight line, with one top pointed to the cranial side and one to the caudal side. A crescent area around the areola was de-epithelialized in the 12 o’clock and 6 o’clock directions. Columnar-shaped breast tissue and an equilateral triangular skin flap and fatty tissue were removed together. To fill the defect, a skin-glandular flap was slid horizontally after suturing the inframammary line. Although an incision scar was formed on the breast and lateral chest wall in a Z-shape, this new technique was able to achieve not only cancer control but also excellent cosmetic results.
Automatic generation of atomic multiplicity-preserving search operators for search-based model engineering
Authors: Burdusel Alexandru , Zschaler Steffen , John Stefan 
Published: August 2021

AbstractRecently, there has been increased interest in combining model-driven engineering and search-based software engineering. Such approaches use meta-heuristic search guided by search operators (model mutators and sometimes breeders) implemented as model transformations. The design of these operators can substantially impact the effectiveness and efficiency of the meta-heuristic search. Currently, designing search operators is left to the person specifying the optimisation problem. However, developing consistent and efficient search-operator rules requires not only domain expertise but also in-depth knowledge about optimisation, which makes the use of model-based meta-heuristic search challenging and expensive. In this paper, we propose a generalised approach to automatically generate atomic multiplicity-preserving search operators for a given optimisation problem. This reduces the effort required to specify an optimisation problem and shields optimisation users from the complexity of implementing efficient meta-heuristic search mutation operators. We evaluate our approach with a set of case studies and show that the automatically generated rules are comparable to, and in some cases better than, manually created rules at guiding evolutionary search towards near-optimal solutions.
Climate change impacts on rainfed maize yields in Zambia under conventional and optimized crop management
Authors: Siatwiinda Siatwiinda M. , Supit Iwan , van Hove Bert , Yerokun Olusegun , Ros Gerard H. , de Vries Wim 
Published: August 2021

AbstractMaize production in Zambia is characterized by significant yield gaps attributed to nutrient management and climate change threatens to widen these gaps unless agronomic management is optimized. Insights in the impacts of climate change on maize yields and the potential to mitigate negative impacts by crop management are currently lacking for Zambia. Using five Global Circulation models and the WOFOST crop model, we assessed climate change impacts on maize yields at a 0.5° × 0.5° spatial resolution for RCP 4.5 and RCP 8.5 scenarios. Impacts were assessed for the near future (2035-2066) and far future (2065-2096) in comparison with a reference period (1971-2001). The surface temperature and warm days (above 30 °C) are projected to increase strongly in the southern and western regions. Precipitation is expected to decline, except in the northern regions, whereas the number of wet days declines everywhere, shortening the growing season. The risk of crop failure in western and southern regions increases due to dry spells and heat stress, while crops in the northern regions will be threatened by flooding or waterlogging due to heavy precipitation. The simulated decline in the water-limited and water- and nutrient-limited maize yields varied from 15 to 20% in the near future and from 20 to 40% in the far future, mainly due to the expected temperature increases. Optimizing management by adjusting planting dates and maize variety selection can counteract these impacts by 6-29%. The existing gaps between water-limited and nutrient-limited maize yields are substantially larger than the expected yield decline due to climate change. Improved nutrient management is therefore crucial to boost maize production in Zambia.
Cyanobacterial growth and cyanophycin production with urea and ammonium as nitrogen source
Authors: Canizales S. , Sliwszcinka M. , Russo A. , Bentvelzen S. , Temmink H. , Verschoor A. M. , Wijffels R. H. , Janssen M. 
Published: August 2021

AbstractSeveral technologies have aimed to recover nitrogen directly from urine. Nitrogen recovery in these technologies was limited by the mismatch of the nitrogen-phosphorus molar ratio (N:P) of urine, being 30–46:1, and that of the final product, e.g., 1:1 in struvite and 16–22:1 in microalgae biomass. Additionally, the high nitrogen concentrations found in urine can be inhibitive for growth of microorganisms. Cyanobacteria were expected to overcome phosphorus (P) limitation in urine given their ability to store an N-rich polymer called cyanophycin. In this study, it was found that the model cyanobacterium Synechocystis sp. PCC6803 did not experience significant growth inhibition when cultivated in synthetic medium with concentrations of 0.5 g ammonium-N L−1. In the case of urea, no inhibition was observed when having it as sole nitrogen source, but it resulted in chlorosis of the cultures when the process reached stationary phase. Synechocystis was successfully cultivated in a medium with 0.5 g ammonium-N L−1 and a N:P ratio of 276:1, showing the N:P flexibility of this biomass, reaching biomass N:P ratios up to 92:1. Phosphorus starvation resulted in cyanophycin accumulation up to 4%. Dilution of the culture in fresh medium with the addition of 118 mg N L−1 and 1.5 mg P L−1 (N:P of 174:1) resulted in a rapid and transient cyanophycin accumulation up to 11%, after which cyanophycin levels rapidly decreased to 3%.
Effects of Employee Sickness Presence on Customer Repurchase and Recommendation Intentions: The Role of Customer Affective Reactions
Authors: Dietz Carolin , Zacher Hannes 
Published: August 2021

AbstractSickness presence can have important individual and organizational consequences, such as health deterioration or productivity loss. Additional risks, such as negative customer reactions, may be particularly relevant in the service sector. Based on affective events theory and appraisal theories, we hypothesize that employee sickness presence negatively impacts customer repurchase and recommendation intentions. Furthermore, we explore potential affective mechanisms of these effects, including disease avoidance, personal anger, moral outrage, post-consumption guilt, and customer compassion for the employee. We conducted four studies, including three experimental vignette methodology studies (Ns = 227, 72, and 763) and a qualitative study (N = 54). In Study 1, employee sickness presence had negative effects on repurchase and recommendation intentions. Results of Study 2 show that customers experienced disgust, fear, anger, guilt, compassion, and indifference in response to sickness presence. In Study 3, anger explained the negative effects of employee sickness presence on repurchase and recommendation intentions, while appraisals of moral fairness were negatively related to both customer intentions. Finally, in Study 4, disgust and anger explained negative effects, while fear, guilt, and compassion explained positive effects of employee sickness presence on customer intentions. Appraisals of goal incongruence, reduced agency of the customer, and uncertainty were negatively related to customer intentions. The physical absence of the customer in the service encounter (phone call) mitigated the experience of disgust, fear, and anger, whereas it exacerbated feelings of compassion for the ill employee.