bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Aspects in Early Adjustment After Severe Burn Injury
Authors: Sirancova Katarina , Raudenska Jaroslava , Zajicek Robert , Dolezal Daniel , Javurkova Alena 
Published: March 2021

Abstract
Burn injury is one of the most serious traumatic events with possible psychological and psychosocial consequences. Health status perception is one of the main health outcomes. The severity of psychological symptoms does not always correlate with that of the burn injury, suggesting that early screening for psychological vulnerabilities may be beneficial. The aim of our study was to identify the personality, clinical, and sociodemographic characteristics related to patient’s subjective perception of health, depression, and anxiety in a sample of 52 adult patients with severe burn injury shortly before discharge from specialty burn clinic. Subjective health perception was predicted by depression (β = −.143, t(47) = −3.94, P &lt; .001) and neuroticism (β = -.106, t(43) = −4.83, P &lt; .001), and it correlated positively with extraversion (r = .2858, P = .0465) and conscientiousness (r = .3663, P = .0096). Depression was predicted by neuroticism (F(1,49) = 18.4; P &lt; .001) and correlated with attachment avoidance (r = .29, P = .0383) and negatively with extraversion (r = −.32, P = .0220). Anxiety was related to attachment anxiety (F(1,49) = 4.25; P = .045), neuroticism (F(1,49) = 15.75; P &lt; .001), and agreeableness (r = −.36, P = .0101). Unemployed patients experienced higher levels of depression and anxiety. This research suggests that personality traits and adult attachment may play an important role in the acute phase of the recovery from a severe burn injury. These findings can be relevant for early intervention and holistic rehabilitation.
The Impact of Peer Support Group Programs on Psychosocial Outcomes for Burn Survivors and Caregivers: A Review of the Literature
Authors: Won Paul , Bello Mariel S , Stoycos Sarah A , Carrera Brenda T , Kurakazu Dawn M , Briere John , Garner Warren L , Gillenwater Justin , Yenikomshian Haig A 
Published: March 2021

Abstract
Peer support group programs are often recommended for burn survivors as a way to facilitate their psychosocial recovery and reintegration into the community. Such programs provide opportunities for burn patients and their caretakers to access emotional and informational support from healthcare providers and other survivors in inpatient or outpatient settings. Despite their popularity, however, there is little information currently available on the efficacy of these groups. In response, we reviewed the existing literature on peer support group programs and their impacts on psychosocial outcomes for burn survivors and their caregivers. A systematic review of the literature utilizing PubMed, PsycINFO, and Medline databases was conducted for articles published between 1990 and 2018. Twenty-five articles including inpatient, outpatient, integrative peer support groups, and burn camps met our inclusion criteria. All inpatient peer support group program articles (n = 4) reported associations with psychosocial improvements. Integrative peer support group program articles (n = 2) reported associations with social integration and reduction in post-traumatic stress and anxiety. All outpatient peer support group program articles (n = 8) demonstrated associations with psychosocial outcomes involving life satisfaction, acceptance of self, and reduced levels of isolation. Findings were less consistent for burn camps: eight articles suggested improvements in psychological outcomes while three articles reported no significant psychosocial effects. Although these results are encouraging, further study is indicated both to replicate these findings, and to determine the optimal implementation of inpatient and outpatient peer support programs.
Reevaluating Conscience Clauses
Authors: Kane Tiernan B 
Published: March 2021

Abstract
Ronit Stahl and Ezekiel Emanuel have recently issued a stark challenge to conscience protections in medical law and ethics. Their argument is flawed, however. They misrepresent the nature and relevance of conscientious protection in the military, misinterpret the scope of consent tendered by modern medical professionals, and offer no reason to think either that conscientious objection harms patient well-being or that such harm should solely determine the permissibility of conscientious objection. Moreover, and most fundamentally, Stahl and Emanuel do not recognize that conscience protections promote moral integrity, a basic aspect of human well-being that justifies protective action.
“Whatever it Takes”: Sexual Harassment in the Context of Resource Dependence
Authors: Beaton Erynn E , LePere-Schloop Megan , Smith Rebecca 
Published: March 2021

AbstractResearch suggests powerful resource dependencies are present in the public and nonprofit sectors. The individuals operating at the nexus between organizations and resource providers, and who mitigate dependencies, are referred to as boundary spanners. Research suggests that there may be both positive and negative personal repercussions for boundary spanners, but research has not sufficiently examined these unintended consequences through a gender lens. Bringing together research on resource dependence and sexual harassment, this study explores sexual harassment as an unintended consequence for boundary spanners of resource dependence mitigation strategies. Drawing on a feminist methodology and purposive sampling, we engaged in interviews with 36 professional fundraisers, a quintessential boundary spanning role, to examine the problem of sexual harassment by donors. These experiences leave fundraisers feeling harassed by donors and exploited by employers that pressure them to do “whatever it takes” to obtain donations. We contribute to research on resource dependence by surfacing sexual harassment and exploitation as unintended consequences for boundary spanners of strategies to mitigate organizational resource dependence. Our findings assist in reconsidering the assumptions that underly resource dependence theory and related research.
Two-step sampling can produce triphasic species–area relationship
Authors: Pan Xubin 
Published: March 2021

AbstractAimsIt is important to explore the underlying mechanisms that cause triphasic species–area relationship (triphasic SAR) across different scales in order to understand the spatial patterns of biodiversity.MethodsInstead of theory establishment or field data derivation, I adopted a data simulation method that used the power function of SAR to fit log-normal distribution of species abundance.Important FindingsThe results showed that one-step sampling caused biphasic SAR and n-step sampling could cause 2n-phasic SAR. Practical two-step sampling produced triphasic SAR due to the Preston and Pan effects in large areas. Furthermore, before exploring biological or ecological mechanisms for the nature phenomenon, we should identify or exclude potential mathematical, statistical or sampling reasons.
Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity
Authors: Asa Anie Day D C , Wanotayan Rujira , Sharma Mukesh Kumar , Tsukada Kaima , Shimada Mikio , Matsumoto Yoshihisa 
Published: March 2021

Abstract
Non-homologous end joining is one of the main pathways for DNA double-strand break (DSB) repair and is also implicated in V(D)J recombination in immune system. Therefore, mutations in non-homologous end-joining (NHEJ) proteins were found to be associated with immunodeficiency in human as well as in model animals. Several human patients with mutations in XRCC4 were reported to exhibit microcephaly and growth defects, but unexpectedly showed normal immune function. Here, to evaluate the functionality of these disease-associated mutations of XRCC4 in terms of radiosensitivity, we generated stable transfectants expressing these mutants in XRCC4-deficient murine M10 cells and measured their radiosensitivity by colony formation assay. V83_S105del, R225X and D254Mfs*68 were expressed at a similar level to wild-type XRCC4, while W43R, R161Q and R275X were expressed at even higher level than wild-type XRCC4. The expression levels of DNA ligase IV in the transfectants with these mutants were comparable to that in the wild-type XRCC4 transfectant. The V83S_S105del transfectant and, to a lesser extent, D254Mfs*68 transfectant, showed substantially increased radiosensitivity compared to the wild-type XRCC4 transfectant. The W43R, R161Q, R225X and R275X transfectants showed a slight but statistically significant increase in radiosensitivity compared to the wild-type XRCC4 transfectant. When expressed as fusion proteins with Green fluorescent protein (GFP), R225X, R275X and D254Mfs*68 localized to the cytoplasm, whereas other mutants localized to the nucleus. These results collectively indicated that the defects of XRCC4 in patients might be mainly due to insufficiency in protein quantity and impaired functionality, underscoring the importance of XRCC4’s DSB repair function in normal development.
The Trope of the Papers: Rethinking the (Un)Documented in African American Literature
Authors: Arrizón-Palomera Esmeralda 
Published: March 2021

AbstractI argue for a reconceptualization of undocumentedness, the experience of being undocumented, from an experience that is simply a result of the modern immigration regime to an experience that is a result of interlocking systems of oppression and resistance to them that has shaped Blackness and the vision for black liberation. I make this argument by defining and tracing the trope of the papers—the use of legal and extralegal documents to examine and document African Americans’ and other people of African descent’s relationship to the nation-state—in the slave narrative and the neo-slave narrative. I offer a close readings of slave narratives, including Sojourner Truth’s The Narrative of Sojourner Truth (1850) and Harriet Jacobs’ Incidents in the Life of a Slave Girl, Written by Herself, and neo-slave narratives, including Toni Morrison’s A Mercy (2008) and Gayl Jones’s Mosquito (1999), to illustrate the significance of the undocumented immigrant in African American literature and demonstrate that writers of African American literature have been thinking intensely about undocumentedness, although not in the way undocumentedness is typically understood.
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
Authors: Roufas Constantinos , Georgakopoulos-Soares Ilias , Zaravinos Apostolos 
Published: March 2021

Abstract
Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the determinants of immune response in CRC, we explored whether patients with diverse levels of immune cytolytic activity (CYT) have different patterns of chromothripsis and kataegis. Analysis of CRC genomic data from the TCGA, indicated an excess of chromothriptic clusters among CYT-low colon adenocarcinomas, affecting known cancer drivers (APC, KRAS, BRAF, TP53 and FBXW7), immune checkpoints (CD274, PDCD1LG2, IDO1/2 and LAG3) and immune-related genes (ENTPD1, PRF1, NKG7, FAS, GZMA/B/H/K and CD73). CYT-high tumors were characterized by hypermutation, enrichment in APOBEC-associated mutations and kataegis events, as well as APOBEC activation. We also assessed differences in the most prevalent mutational signatures (SBS15, SBS20, SBS54 and DBS2) across cytolytic subgroups. Regarding the composition of immune cells in the tumor milieu, we found enrichment of M1 macrophages, CD8+ T cells and Tregs, as well as higher CD8+ T-cells/Tregs ratio among CYT-high tumors. CYT-high patients had higher immunophenoscores, which is predictive of their responsiveness if they were to be treated with anti-PD-1 alone or in combination with anti-CTLA-4 drugs. These results could have implications for patient responsiveness to immune checkpoint inhibitors.
Near-infrared brightening around the periastron passages of the gamma-ray binary PSR B1259−63 / LS 2883
Authors: Kawachi Akiko , Moritani Yuki , Okazaki Atsuo T , Yoshida Hiromi , Suzuki Kenta 
Published: March 2021

Abstract
The binary of the pulsar PSR B1259−63 and the Be star LS 2883 has been observed at the 2010 and 2014 periastron passages in the near-infrared (NIR) bands using the IRSF/SIRIUS and SIRPOL. The light curves in the J-, H-, and Ks-bands are almost identical in these periastron passages. A flare starts no later than 10 days before periastron and the maximum brightening of about 0.1 mag is observed 12–17 days after periastron. The rising part of the light curve is steeper and reaches a peak slightly earlier in the Ks-band than in the other bands, thus a characteristic track appears on the NIR color–magnitude diagram. The time lag between the NIR light curves indicates that the variation in the Be circumstellar disk first occurs in an outer region. We propose that the initial rapid contraction followed by the gradual expansion of the disk is evoked by the rapidly changing tidal torque around periastron and the resultant change of the optically thick area causes the observed NIR light curves.
A mixed method study exploring patient satisfaction and feasibility of two exercise programmes in systemic sclerosis-associated microstomia
Authors: Sydow Ellinor , Van der Elst Kristien , Verschueren Patrick , Lenaerts Jan , Westhovens René , De Langhe Ellen 
Published: March 2021

Abstract

Objective
SSc often leads to fibrotic cutaneous involvement of the face and reduced oral aperture, with impaired food intake and oral hygiene. Oral exercises can increase oral aperture but are often hampered by low adherence rates. The aim of this mixed method study was to explore the feasibility, patient satisfaction and effectiveness of two exercise programmes in SSc-associated microstomia.

Methods
Adult patients suffering from SSc and microstomia (maximal oral aperture &lt;40 mm) were randomized to two groups. Group A exercised with a jaw motion device (Therabite), whereas group B performed mouth-stretching exercises. Patients were expected to exercise for 10 min, three times per day for 3 months. Patients were evaluated at baseline, 3 months (period without intervention), 6 months (after 3 months of intervention) and 9 months (post-intervention). At month 6, semi-structured one-to-one interviews were conducted.

Results
We included six women and three men, median age 60 years and median disease duration 8 years. At 6 months, all patients in group A (n = 4) and four in group B (n = 5) improved, with a median of 9 and 7 mm, respectively. The adherence ranged between 63.7 and 98.9% in group A and between 48.5 and 97.4% in group B. The interview revealed three themes: drivers, challenges and perceived improvement.

Conclusion
Both interventions improved maximal oral aperture. The adherence to therapy was high, but none of the patients considered it feasible to continue practising three times per day. Future studies are needed in order to define feasible long-term exercise programmes.
Exploring the active ingredients of workplace physical and psychological wellbeing programs: a systematic review
Authors: Ryan J C , Williams G , Wiggins B W , Flitton A J , McIntosh J T , Carmen M J , Cox D N 
Published: March 2021

Abstract
Previous reviews have established that workplace wellbeing initiatives are effective at promoting wellbeing, but less is known about which intervention characteristics or “active ingredients” underpin this effectiveness (i.e., behavior change techniques [BCTs]). This review aims to illuminate the connections between the types of BCTs and the level of intervention intensity with intervention effectiveness. A systematic search for peer-reviewed studies evaluating a workplace wellbeing initiative was undertaken across five databases: Medline, Scopus, PsycInfo, and CINAHL (Ovid Emcare). Eligible studies included those that evaluated the effect of a workplace wellbeing initiative on participants’ physical wellbeing (e.g., physical activity and quality of life) and psychological wellbeing (e.g., mental health and stress), were published between 2009 and September 2019, and utilized a comparator (e.g., control group or prepost change). Studies were screened in independent duplicate to minimize bias. Effect sizes were calculated. Following removal of duplicates, 1,541 studies were identified and screened for eligibility. Of these, 23 studies reporting 28 comparisons were deemed to meet eligibility criteria. Just over 50% of these studies reported evidence of either a strong or moderate effect across a physical and a psychological outcome, providing a positive indication that workplace wellbeing programs can promote physical and psychological wellbeing in workers. Interventions tended to employ multiple BCTs (mean range 8.1–9.4), however, no discernible patterns between the types or numbers of BCTs employed and intervention effectiveness was found. Further experimental work is required that compares and contrasts workplace wellbeing initiatives to enable a better understanding of how to develop and implement highly effective programs.
Feasibility of patient-focused behavioral interventions to support adults experiencing chronic noncancer pain during opioid tapering: a systematic literature review
Authors: White Ruth , Bruggink Laura , Hayes Chris , Boyes Allison , Paul Chris 
Published: March 2021

Abstract
Guidelines for chronic noncancer pain prioritize behavioral treatments. In clinical practice transition from opioids to behavioral treatments is often not endorsed by patients or providers. Feasible interventions to support opioid tapering are needed, particularly in primary care.
The objectives of this paper is to review the feasibility of behavioral interventions to support opioid tapering.
Electronic databases (MEDLINE, Embase, PsycINFO, and CINAHL) were searched from inception to June 2019 to identify original studies reporting feasibility (consent rates; completion rates; patient-reported acceptability; integration into clinical practice; and adverse events) of opioid tapering and transition to behavioral treatments for adults experiencing chronic noncancer pain. Google scholar and contents tables of key journals were also searched. Two authors independently extracted data and assessed methodological quality using The Quality Assessment Tool for Quantitative Studies. Eleven publications met inclusion criteria, of which three were conducted in primary care. Consent rates ranged from 27% to 98% and completion rates from 6.6% to 100%. Four studies rated at least one component of patient acceptability: helpfulness from 50%–81%; satisfaction 71%–94%, and “recommend to others” 74%–91%. Three studies reported provider perspectives and two studies reported adverse events. Quality assessment indicated all 11 studies were moderate or weak, primarily due to selection bias and lack of assessor blinding. There was also considerable heterogeneity in study design. The limited available data suggest that attempts to translate opioid tapering interventions into practice are likely to encounter substantial feasibility challenges. One possible way to ameliorate this challenge may be a clear policy context, which facilitates and support opioid reduction.
Using a population health management approach to enroll participants in a diabetes prevention trial: reach outcomes from the PREDICTS randomized clinical trial
Authors: Wilson Kathryn E , Michaud Tzeyu L , Almeida Fabio A , Schwab Robert J , Porter Gwenndolyn C , Aquilina Kathryn H , Brito Fabiana A , Golden Caitlin A , Dressler Emily V , Kittel Carol A , Harvin Lea N , Boggs Ashley E , Katula Jeffrey A , Estabrooks Paul A 
Published: March 2021

Abstract
Population health management (PHM) strategies to address diabetes prevention have the potential to engage large numbers of at-risk individuals in a short duration. We examined a PHM approach to recruit participants to a diabetes prevention clinical trial in a metropolitan health system. We examined reach and representativeness and assessed differences from active and passive respondents to recruitment outreach, and participants enrolled through two clinical screening protocols. The PHM approach included an electronic health record (EHR) query, physician review of identified patients, letter invitation, and telephone follow-up. Data describe the reach and representativeness of potential participants at multiple stages during the recruitment process. Subgroup analyses examined proportional reach, participant differences based on passive versus active recruitment response, and clinical screening method used to determine diabetes risk status. The PHM approach identified 10,177 potential participants to receive a physician letter invitation, 60% were contacted by telephone, 2,796 (46%) completed telephone screening, 1,961 were eligible from telephone screen, and 599 were enrolled in 15 months. Accrual was unaffected by shifting clinical screening protocols despite the increase in participant burden. Relative to census data, study participants were more likely to be obese, female, older, and Caucasian. Relative to the patient population, enrolled participants were less likely to be Black and were older. Active respondents were more likely to have a higher income than passive responders. PHM strategies have the potential to reach a large number of participants in a relatively short period, though concerted efforts are needed to increase participant diversity.
Comparison of ABTS/DPPH assays for the detection of antioxidant capacity in foods
Authors: Floegel Anna , Kim Dae‐Ok , Chung Sang‐Jin , Chun Ock K. 
Published: March 2021

The present study aimed to evaluate two different spectrophotometric assays for detection of vitamin C equivalent antioxidant capacity (VCEAC) of foods. Fifty popular, antioxidant‐rich fruits, vegetables and beverages in the U.S. diet were analyzed for their 2,2′‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulphonic acid (ABTS) anion radical scavenging activity (ABTS assay) and their ability to reduce 1,1‐diphenyl‐2picrylhydrazyl (DPPH) radical (DPPH assay). The highest VCEAC was detected for strawberry with 520.7 ± 39.3 mg vitamin C equivalent (VCE)/100 g by DPPH assay and for blueberry with 476.6 ± 28.9 mg VCE/100 g by ABTS assay. Although the order differed slightly, both assays identified the same top ten VCEAC food items in the U.S. diet based on fresh weight as blueberry, plum, strawberry, red cabbage, red wine, grape, cherry, green tea, broccoli and apple. VCEAC of 50 food items detected by ABTS assay showed a strong positive relationship with VCEAC measured by DPPH assay (r = 0.886, p<0.001). VCEAC detected by ABTS assay demonstrated a stronger positive association with the USDA database for the oxygen radical absorbance capacity (ORAC) (r = 0.473, p < 0.01). ABTS assay was superior to DPPH assay in reflecting the antioxidant levels of foods containing hydrophilic, lipophilic, high‐moisture, or high‐pigmented nutrients. Hence, ABTS assay may be more useful than DPPH assay in detecting VCEAC in foods.Grant Funding Source: Supported by Beginning Grant in Aid (BGIA) No. 0865092E from the American Heart Association and University of Connecticut Faculty Large Grant