bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Penempatan Dan Kebutuhan Proteksi Katodik Pada Sistem Pipa Gas Bawah Laut Offshore Dari Pulau Pemping Ke Tanjung Uncang Batam
Authors: Azisah Nur , Paroka Daeng , Wahyuddin Wahyuddin 
Published: April 2021

Korosi merupakan suatu permasalahan yang sering terjadi pada rangkaian pipa bawah laut. Hal ini dikarenakan material pipa logam yang dipasang di lingkungan yang memiliki tingkat korosifitas tinggi. Walaupun korosi tidak dapat dihindari atau dihilangkan, namun dapat dikendalikan untuk meminimalisir kerusakan pada pipa dengan melakukan perancangan proteksi katodik. Salah satunya adalah dengan menggunakan metode anoda korban. Penelitian ini bertujuan untuk membuat rancangan pengendalian laju korosi pada pipa bawah laut sepanjang 13,5 km, berdiameter 16 inci untuk umur desain 45 tahun dimana kebutuhan proteksi tiap meter pipa dianggap sama. Anoda yang digunakan adalah anoda gelang dengan panjang 400 mm dan tebal 40 mm yang berbahan paduan aluminium. Dalam perancangan proteksi katodik ini, penulis mengacu pada ketentuan DNVGL-F103 dan ISO 15589-2. Dari hasil penelitian ini, akan di dapatkan total anoda yang dibutuhkan untuk memproteksi pipa serta jarak pemasangan antar anoda. Berdasarkan total anoda tersebut, dapat diketahui estimasi biaya yang diperlukan dalam pembuatan proteksi katodik.
Menganalisis Karakteristik Sedimen Dan Morfologi Muara Sungai Kapuas Guna Memperlancar Alur Pelayaran
Authors: Budiman Farid , Setyawan Yudha , Ando Yosafat Aditya 
Published: April 2021

Abstrak

Muara sungai merupakan tempat pertemuan antara air laut dengan air sungai dan merupakan bagian hilir dari sungai. Pada dasar perairan muara sungai terjadi pengendapan, karena terjadi pertemuan partikel pasir/lumpur yang dibawa oleh arus sungai bertemu dengan pasir berada di daerah sekitar pantai. Berkaitan dengan hal tersebut, maka sangat penting untuk meneliti karakteristik dari muara serta karakteristik sedimennya, khususnya untuk memberikan informasi kepada masyarakat sekitar serta memberikan data mengenai karakteristik sedimen yang mengendap untuk menentukan metode pengerukan yang lebih efisien atau mencari solusi agar tidak dilakukan pengerukan tiap tahunnya. Penelitian ini dilaksanakan di Laboratorium Mekanika Tanah Fakultas Teknik Universitas Tanjungpura serta pada penggambilan sampel sedimen di Muara Sungai Kapuas. Waktu pengambilan sampel sedimen pada 9 titik dan pengambilan data batimetri pada 21 titik adalah tanggal 14 juni 2019 sedangkan untuk uji laboratorium pada tanggal 14 – 22 juni 2019. Metode yang digunakan ialah purpose sampling untuk mengambil sampel di lapangan, metode kuantitatif untuk pengujian di laboratorium. Untuk analisa data menggunakan metode sistem USDA dan kategori kemiringan Van Zuidam. Dari hasil pengambilan data lapangan, menunjukkan bahwa batimetri di Muara Sungai Kapuas berkisar antara 2,6 m hingga 8,7 m pada MSL +0,8 m dengan kontur dasar di Muara Sungai Kapuas di kategorikan Datar. Jenis sedimen dasar di Muara Sungai Kapuas didominasi oleh kategori tanah liat berlanau. Sedimen bisa berasal dari pantai berlumpur yang mengalami abrasi oleh aliran air. Oleh karena itu, solusi agar tidak dikeruk setiap tahunnya maka perlu dibangun Jetty atau dinding penahan pantai.
Comments: JPT’s New Website
Authors: Smith Glenda 
Published: April 2021

I hope that, by now, most of you have seen our new magazines website, which launched on 1 February. Beyond a clean, modern design that is mobile friendly, our goal was to make our content even more accessible and valuable to you. If you have not visited the new site, I would encourage you to do so at jpt.spe.org.
SPE has been working on transforming our digital presence, and this new website is a big step forward in that journey. We have made it easier for you to find content that is valuable to you. JPT and our other magazines generate a lot of articles beyond those in the monthly JPT issue—technical content that crosses all disciplines, along with news to help you stay up to date with what is happening in our industry. By bringing all our magazines together in a single site, we have made it possible for content from the different publications to be combined easily, allowing you to find everything we have published on a subject of interest.
The website is organized broadly by discipline but also by topics within those disciplines, giving you the choice of scanning articles broadly or in a more focused manner. Each article has topics and more specific tags at the bottom of the page. These are clickable to allow you to find even more related content. The site has a terrific search engine, so whether you’re searching for information on human factors, discoveries off Guyana and Suriname, or electric submersible pumps, it will direct you to our most relevant content.
If you log in and you have given SPE your primary and secondary disciplines, there is a section of the homepage that will recommend relevant recent content that you may have missed. The homepage also includes a sampling of discipline-specific content at the bottom of the page, a couple of topical focus areas that will change periodically, sponsored content, and the most recent 2 months of technical paper synopses.
Another change you may notice is locked content, starting with the technical paper synopses. This is content that we develop specifically for you—our members—and we want to ensure that it is the member benefit that it was intended to be. We are still making the full-length technical papers available to members for down-load. You will find them at the end of each related synopsis, as well as in the issue article on the homepage (right column, about halfway down).
Bookmark our new website (jpt.spe.org) and visit regularly to stay up to date. You can share any feedback at JPTcomments@spe.org.
Well-Flux Surveillance and Ramp-Up Method for Openhole Standalone Screen Completion
Authors: Feder Judy 
Published: April 2021

This article, written by JPT Technology Editor Judy Feder, contains highlights of paper SPE 201662, “A Well-Flux Surveillance and Ramp-Up Method for Openhole Standalone Screen Completion,” by Mehmet Karaaslan and George K. Wong, University of Houston, and Kevin L. Soter, SPE, Shell, et al., prepared for the 2020 SPE Annual Technical Conference and Exhibition, originally scheduled to be held in Denver, Colorado, 5-7 October. The paper has not been peer reviewed.
Production and surveillance engineers need practical models to help maximize production while avoiding ramping up the well to an extent that the completion is damaged, causing well impairment or failure. The complete paper presents a well-flux surveillance method to monitor and ramp up production for openhole standalone screen (OH-SAS) completions that optimizes production by considering risks of production impairment and screen-erosion failure.
Challenges of Increased Production vs. Well Failure
The problem of increased production vs. the risk of well impairment or failure is a pressing problem for sand-control wells in deepwater, where projects tend to have a small number of high-rate wells. In such environments, any well impairments or failures greatly affect the project economics.
Following unloading, well surveillance faces the critical step of ramping up to-ward the well’s designed peak rate for the first time when the actual well performance is uncertain. To reduce risk of well impairment or failure, surveillance information and models are needed to help make adjustments during the ramp-up process. Different models are available, from simple to complex and from small to large amounts of input data and computational efforts. Simple nonsurveillance models use field-derived operating limits of completion pressure drop and flow velocity or flux. They are non-surveillance models in the sense that no direct linkage of surveillance results to update flux calculations exists. Simple surveillance models use pressure transient analysis (PTA) results and completion information to evaluate changing well performance and adjust the ramp-up and long-term surveillance operations. The complex surveillance model evaluates well performance and adjusts well operations using probabilistic completion failure risks and coupled reservoir and completion simulations. These models mainly focus on cased-hole gravel pack and frac-pack applications. For openhole completions with sand control, the literature offers limited ramp-up surveillance references.
The objective of the well-flux model described in the complete paper is to ramp up the well safely and optimize production using PTA results as surveillance inputs to calculate completion fluxes for well impairment or failure assessment. The method follows an approach presented in the literature.
Prefetching of Web Objects For Effective Retrieval Process Through Data Mining Techniques
Authors: Singh T S Bhagavath , Chitra S 
Published: April 2021

Abstract
With the exponential increase of the internet’s user base, performance enhancing network architectures and algorithms has manifested themselves as a requisite. Algorithms for Prefetching and Caching of Web Objects have been observed to effectively minimize user perceived latency. These algorithms are made use of in architectures limited to a particular user. We can further improve the performance of these algorithms by making use of techniques like data mining. We propose an innovative idea of implementing Prefetching and Caching algorithms in a Clustered Network. This will enable all users in a particular cluster to make use of pre-fetched and cached web objects from all other users. The result of simulations indicates a reduction in web latency, internet traffic, and bandwidth consumed.
Quercetin and a plant substance, identified using a multi-copy number of DNA topoisomerase I in recombinant Pichia pastoris, inhibited MDA-MB-231 proliferation via different manners.
Authors: Gang Zhao , Pei Chao Sin , Fadzil Nur Adila , Kwok Lim Shern , Lan Chew Ai , Khoo Boon Yin 
Published: April 2021

Abstract
The study employed an in vivo strategy to construct a multi-copy number of human DNA topoisomerase I (hTopI) gene using pPIC3.5K vector in GS115 strain of Pichia. The yeast transformant (GS115-pPIC3.5K-hTopI; clone) was then used to investigate the preliminary growth effect of a pure compound (quercetin) and a standardised subfraction of ethanolic red onion peel extract (F1). The clones’ cell density was likely to be unaffected; only the total protein expression and enzyme activity were increased following the increased copy number of hTop1 in the host. The clone that showed the target enzyme's highest activity is said to respond specifically to growth inhibitors, whereby both quercetin and F1 were proven to be potential growth inhibitors as assessed by the MTT assay. In the process, quercetin reduced cell proliferation by inducing apoptosis and cell cycle arrest (S phase only), whereas F1 reduced cell proliferation by inducing cell cycle arrest only (S and G2 phases). Quercetin and F1 induced CYP1A1 and CYP1B1 (carcinogenicity) gene mRNA expression, but only F1 induced CYP2S1 (cytotoxicity) gene mRNA expression in the treated cells, suggesting that both quercetin and F1 inhibited the cell proliferation of MDA-MB-231 via different manners. The newly developed GS115-pPIC3.5K-hTopI can be used to select various potential substances for breast cancer treatment in the future.
Exogenous D-β-Hydroxybutyrate Lowers Blood Glucose by Decreasing the Availability of L-Alaninefor Gluconeogenesis
Authors: Mota Adrian Soto , Norwitz Nicholas , Evans Rhys , Clarke Kieran 
Published: April 2021

Abstract
BackgroundInterventions that acutely increase blood ketone concentrations simultaneously lower blood glucose levels, although the explanation for this phenomenon is unknown. The hypoglycaemic effect of acute ketosis is greater in people with type 2 diabetes (T2D) in whom gluconeogenesis contributes significantly to hyperglycaemia. L-alanine is a gluconeogenic substrate secreted by skeletal muscle at higher levels in people with T2D. As infusion of ketones lower circulating L-alanine blood levels, we sought to determine whether supplementation with L-alanine would attenuate the hypoglycaemic effect of an exogenous ketone ester (KE) supplement.MethodsThis crossover study involved 10 healthy human volunteers who fasted for 24 hours prior to the ingestion of 25 g of D-β-hydroxybutyrate (βHB) in the form of a KE drink (ΔG®) on two separate visits. During one of the visits participants additionally ingested 2 g of L-alanine to see if L-alanine supplementation would attenuate the hypoglycaemic effect of the KE drink. Blood L-alanine, L-glutamine, glucose, βHB, free fatty acids (FFA), lactate, and C-peptide were measured every fifteen minutes for 120 minutes after ingestion of the KE, with or without L-alanine.FindingsThe KE drinks elevated blood βHB concentrations from negligible levels to 4.5 ± 1.24 mmol/L, lowered glucose from 4.97 to 3.77 ± 0.4 mmol/L, and lowered and L-alanine from 0.56 to 0.41 ± 0.9 mmol/L. L-alanine in the KE drink elevated blood L-Alanine to 0.68 ± mmol/L, but had no significant effect on blood βHB, L-glutamine, FFA, lactate, nor C-peptide concentrations. By contrast, L-alanine supplementation significantly attenuated the ketosis-induced drop in glucose from 28% to 16% (p<0.001).ConclusionsThe hypoglycaemic effect of acutely elevated βHB is partially due to βHB decreasing L-alanine availability as a substrate for gluconeogenesis.
PAFAH1B3 predicts poor prognosis and promotes progression in lung adenocarcinoma
Authors: Tang Suping , Ni Jun , Chen Bohua , Sun Fei , Ni Songshi , Tang Zhiyuan 
Published: April 2021

Abstract
Background

Recently, increasing evidence has indicated that platelet-activating factor acetylhydrolase 1b catalytic subunit 3 (PAFAH1B3) plays an important role in several cancers. However, the role in lung adenocarcinoma (LUAD) has not been reported until now.
Methods

Expression of PAFAH1B3 in LUAD was determined by Gene Expression Profiling Interactive Analysis (GEPIA), real-time PCR (RT-PCR), Western blot and Immunohistochemical (IHC) analysis. LUAD datasets with clinical information were obtained from The Cancer Genome Atlas Program (TCGA). Chi-square test was used to investigate the correlation between PAFAH1B3 expression and clinical parameters. Cox regression and Kaplan-Meier analysis were performed to analyzed the prognostic value of PAFAH1B3. CCK-8 assay, clone formation assay, transwell invasion assay and flow cytometry were conducted to detect cell proliferation, clone formation, invasion and cell cycle. Western blot was performed to detect epithelial-to-mesenchymal transition (EMT)-related markers. Immune Cell Abundance Identifier (ImmuneCellAI) was used to analyze the effect of PAFAH1B3 on immune cell infiltration.
Results

Our study showed that PAFAH1B3 was upregulated in LUAD, and silencing PAFAH1B3 suppressed cell proliferation, colony formation, invasion and increased the cell population in G0-G1 phases in vitro. In addition, tissue microarray IHC analysis showed that the PAFAH1B3 protein level was remarkably correlated with distant metastasis, TNM stage and clinical outcome. Furthermore, multivariate cox regression analysis based on TCGA-LUAD datasets and tissue microarray indicated that PAFAH1B3 was an independent prognostic risk factor for LUAD patients. Moreover, knockdown of PAFAH1B3 inhibited EMT in LUAD cells and PAFAH1B3 mRNA expression was correlated with immune infiltrates.
Conclusion

Our studies indicate that PAFAH1B3, a prognostic risk factor, promotes proliferation, invasion and EMT and affects immune infiltrates in LUAD.
Clinical Characteristics Of Carbapenem Resistant Enterobacteriaceae Bloodstream Infection: A Retrospective Study Among Children
Authors: Song Ting , Pan Fen , Jiang BingXin , Liu Honghong , Zhang Hong , Zhang Ting 
Published: April 2021

Abstract
Purpose: The clinical features and treatment of Carbapenem resistant Enterobacteriaceae（CRE）bacteremia among children were different from the adults. Clinical studies about CRE infection among children was still lack of enough samples. The aim of this study was to share our experience of diagnosis and treatment of CRE bacteremia and to improve the prognosis of children infected with CRE.Methods: Clinical records were systematically reviewed to extract the detailed information and treatment results. Potential risk factors for infection mortality were examined by a case-control study. Case-patients were those who died from the BSI and control-patients those who survived. Data were analyzed to explore the difference of clinical characteristics resulted from CRE infection between neonate and non-neonate group and more appropriate treatment strategy by using SPSS 23.0.Results: A total of 36 CRE BSI were collected from January 2016 to December 2019, including 21 neonates and 15 non-neonates. The mortality due to CRE infection was 25%. K.pneumoniae (22, 61.1%) was the main pathogen. Patients suffered from different clinical manifestions, including fever(24, 66.7%), Breath holding spell(13, 36.1%), Sepsis（11, 30.6%）, MODS(6, 16.7%), digestive tract symptom(15, 41.6%). The incidence of breath holding spell was higher among newborn group(P<0.05) while the incidence of sepsis was higher among non-neonate group(P<0.05). There was no difference of percentage of underlying diseases between survival group and non-survial group. Combination therapy shown a significant reduction of mortality (P<0.05).Conclusion: Klebsiella.Pneumoniae was the most common isolates among children CRE BSI .Monotherapy maybe appropriate for neonates for those with slightly clinical manifestation resulted from CRE BSI while combination therapy are more effective and could give rise to significant reduction of mortality among children.
A Multifaceted Approach to Supporting Mothers of Premature Infants
Authors: Mohagheghi Parisa , Keramat Afsaneh , Chaman Reza , Khosravi Ahmad , Mousavi Seyed Abbas , Mousavi Seyedeh Saeedeh 
Published: April 2021

Abstract
Background

Premature birth exposes mothers to a strange experience for which they are not mentally ready. Premature birth exposes mothers to a strange experience for which they are not mentally ready. This study aimed to examine the effect of a multi-faceted supportive approach on the levels of perceived support in mothers.
Methods

The present experimental study was conducted on 143 mothers with preterm infants, (In the intervention group, 75 infants and mothers and 68 infants and mothers in the control group), in the NICUs of two educational and referral hospitals of Tehran, Iran; from Feb 14, 2016 to May 14, 2016. The inclusion criteria were: having a preterm infant with gestational age < 37 weeks, birth weight < 2500 gr, high probability of survival, Iranian nationality and ability to communicate verbally. Exclusion criteria were: preterm infants without abnormality or disabling conditions such as intra ventricular hemorrhage (IVH) grade 3 or 4. The designed intervention was conducted based on the support system pattern of mothers with premature infants. Different interventions in support (appraisal, instrumental, emotional, and informational support) of mothers in NICU were planned for the supportive program, which was gradually implemented within 3 months of the intervention. The Nurse Parent Support Tool (NPST) was used to assess the mothers' perceptions of the perceived support. The control group received routine care. The obtained data were analyzed by STATA software 13. Classified variables were analyzed using t-test, chi-square and Inverse Probability Treatment Weights (IPTW).
Results

After adjusted mean differences (95% confidence interval) of outcomes between two groups, results showed that the all support scores including total support, -1.83 (95% CI -1.6 to -2.06), Instrumental support, -1.23 (95% CI -1.04 to -1.43), Emotional support, -1.87 (95% CI -2.15 to 1.6) and Appraisal support, -2.01 (95% CI -1.73 to -2.29), and Informational support, -2.12 (95% CI -1.82 to -2.43), in the experimental group were significantly higher than in the control group (P<0.001).
Conclusions

The information, support and early intervention play important roles in the maternal empowerment to cope with her situation.
Low-Cost Microwave Imaging Portable Device for Breast Cancer Diagnosis
Authors: Aragão Alexandre de Jesus , de Carvalho Dionisio , Sanches Bruno , Noije Wilhelmus A. M. van 
Published: April 2021

Abstract
This paper presents a Microwave Imaging apparatus for breast cancer detection, aiming at early diagnosis, an effective way of reducing mortality rates. In 2020, breast cancer has surpassed lung cancer cases worldwide, with more impact in low-income countries, which motivates seeking a non-invasive and affordable screening equipment. Focusing on low-cost and portability, a US$150.00 embedded hardware transceiver plus antennas platform has been picked out, together with the development of a dry-coupling silicone rubber bra hold by a handheld device. Initially, a losses study to analyze the hardware ability to detect malignant tumors depth in the breast was conducted. Next, simulations and tests employing the platform along with a breast phantom were carried out. This phantom mimics the dielectric breast tissue properties while a confocal algorithm was applied to backscattered signals to generate reconstructed images. Results established a correspondence between simulated and experimental data, SCR and SMR above 7.0 dB and 23.0 dB, respectively, in the resulting images and tumor location precision below 0.3 cm. Based on that, the low-cost portable proposed system results showed its ability as an adjunct early breast cancer diagnosis tool.
On The Bright Side of Life - The Effect of Ambient Light Intensity on Postsurgical Patient-Reported Outcomes
Authors: Scheller Janine , Komann Marcus , Weinmann Claudia , Weinmann Jonas , Scharnagel Stephan , Mielke Anke , Pogatzki-Zahn Esther , Heifeld Stefan , Meissner Winfried 
Published: April 2021

Abstract
Light intensity affects humans in multiple ways. We aimed to characterize the potential impact of light intensity on patients’ pain management experience in the perioperative setting. Within the German multicenter registry project QUIPS, we collected patient reported outcomes (PROs) concerning pain and side effects, demographics and perioperative pain medication, and measured the light intensity in their rooms on the first postoperative day. Primary endpoint was maximum pain intensity rated on the numerical rating scale (NRS, 0-10). Secondary endpoints were pain intensity during movement, mood, nausea, tiredness and satisfaction. Measurement of light intensity was done with a calibrated light meter. For analysis, we used linear and log-linear regression models with age, gender, pre-existing chronic pain, ASA status, and logarithmized light intensity as independent variables. Data of 539 surgical patients from 9 hospitals were included. We found no significant effect of light intensity on the primary endpoint. However, we observed a strong positive correlation between nausea and light intensity. Perspective: Our study indicates that further investigations about the clinical importance of light exposure with regard to nausea and other medical conditions might be worthwhile.Trial registration: QUIPS is registered in the German Clinical Trials Register (DRKS00006153)