bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-Independent Forecast Model For Large Crustal Earthquakes in Southwest Japan Using GNSS Data
Authors: Nishimura Takuya 
Published: December 2021

Abstract
In this study, we developed a regional likelihood model for crustal earthquakes using geodetic strain rate data from southwest Japan. First, smoothed strain rate distributions were estimated from continuous GNSS measurements. Second, we removed the elastic strain rate attributed to interplate coupling on the subducting plate boundary, including the observed strain rate, under the assumption that it is not attributed to permanent loading on crustal faults. We then converted the geodetic strain rates to seismic moment rates and calculated the 30-year probability for M ≥ 6 earthquakes in 0.2 × 0.2° cells, using a truncated Gutenberg–Richter law and time-independent Poisson process. Likelihood models developed using different conversion equations, seismogenic thicknesses, and rigidities were validated using the epicenters and moment distribution of historical earthquakes. The average seismic moment rate of crustal earthquakes recorded during 1583–2020 was only 13–20 % of the seismic moment rate converted from the geodetic data, which suggests that the observed geodetic strain rate includes considerable inelastic strain. Therefore, we introduced an empirical coefficient to calibrate the moment rate converted from geodetic data with the moment rate of the earthquakes. Several statistical scores and the Molchan diagram showed that all models could predict real earthquakes better than the reference model, in which earthquakes occur uniformly in space. Models using principal horizontal strain rates exhibited better predictive skill than those using the maximum horizontal shear strain rate. There was no significant difference in the predictive skill between uniform and variable distributions for seismogenic thickness and rigidity. The preferred models suggested high 30-year-probability in the Niigata–Kobe Tectonic Zone and central Kyushu, exceeding 1% in more than half of the analyzed region. Model predictive skill was also verified by a prospective test using earthquakes recorded during 2010–2020. This study suggests that the proposed forecast model based on geodetic data can improve the regional likelihood model for crustal earthquakes in Japan in combination with other forecast models based on active faults and seismicity.
The Effect of Acellular Dermal Matrix on the Success of Primary Palatoplasty With Intravelar Veloplasty
Authors: Abdali Hossein , Hoghooghi Mohammad Ali , Fattahpour Shirin , Derakhshandeh Fatemeh , Mohtashampour Farnoosh , Ghanei Amin 
Published: December 2021

Abstract
BackgroundAcellular Dermal Matrix graft is usually used to repair fistulas following a cleft palate and has had positive results. But its use for primary palatoplasty has been less studied. Our aim was to compare the usefulness of using Acellular Dermal Matrix transplantation for primary palatoplasty with intravelar veloplasty in contrast to its lack of useMaterials and methodsA total of 72 children (6 months to 6 years old) with cleft palate were included in the study. The case-control prospective observations were conducted. A group underwent primary palatoplasty with intravelar veloplasty using Acellular Dermal Matrix and the control group had the same surgery without using Acellular Dermal Matrix. Patients were monitored for fistula formation, post-operative infection, and ulcers.ResultsNo post-surgical infection and wound opening was seen in any group. In the recipients of Acellular Dermal Matrix and control group three and six fistula was reported in which patients had soft and hard palate involvement and the cleft with length greater than 15 mm.ConclusionsConsidering the double incidence of fistulas in the control group compared to the ADM recipient, it seems that the use of ADM can be effective in reducing the incidence of fistulas. Since fistula is one of the complications of primary palatoplasty surgery and leads to secondary surgeries, the use of ADM can be helpful.
Neural Networks Implicated in Autobiographical Memory Training
Authors: Cȋrneci Dragoş , Onu Mihaela , Papasteri Claudiu C. , Georgescu Dana , Poalelungi Catalina , Sofonea Alexandra , Puşcaşu Nicoleta , Tanase Dumitru , Rădeanu Teofila , Toader Maria-Yaelle , Dogaru Andreea L. , Podină Ioana R. , Berceanu Alexandru I. , Carcea Ioana 
Published: December 2021

Abstract
Training of autobiographical memory has been proposed as intervention to improve cognitive functions. The neural substrates for such improvements are poorly understood. Several brain networks have been previously linked to autobiographical recollections, including the default mode network (DMN) and the sensorimotor network. Here we tested the hypothesis that different neural networks support distinct aspects of memory improvement in response to training on a group of 59 subjects. We found that memory training using olfactory cues increases resting-state intra-network DMN connectivity, and this associates with improved recollection of cue-specific memories. On the contrary, training decreased resting-state connectivity within the sensorimotor network, a decrease that correlated with improved ability for voluntary recall. Moreover, only the decrease in sensorimotor connectivity associated with the training-induced decrease in the TNFα factor, an immune modulation previously linked to improved cognitive performance. We identified functional and biochemical factors that associate with distinct memory processes improved by autobiographical training. Pathways which connect autobiographical memory to both high level cognition and somatic physiology are discussed.
Epidemiology and Clinical Features of Birt-Hogg-Dubé Syndrome: A Nationwide Population-Based Study in South Korea
Authors: Park Hyung Jun , Kim Ye-Jee , Kim Min-Ju , Kim Hocheol 
Published: December 2021

Abstract
Background

Birt–Hogg–Dubé (BHD) syndrome is an ultrarare lung disease with unclear prevalence and incidence. Our study aimed to identify the epidemiological and clinical features of BHD syndrome by using nationwide claims data from the Korean Health Insurance Review and Assessment service.
Results

We found 26 patients with BHD syndrome from 2017 to 2019. The prevalence of BHD syndrome was 5.67 per 107 population, with no peak age. Among incidence cases, the median age of diagnosis was 51 years, with slightly more females than males (n = 15, 57.7%). Over half of the patients (n = 14, 53.8%) experienced pneumothorax, and 10 (38.5%) developed malignant neoplasm within the clinical course.
Conclusions

The prevalence of BHD syndrome in Korea is extremely low. However, affected patients manifest several comorbidities, including malignant neoplasm and repetitive pneumothorax.
Navigating Communication Between Western Medicine And Traditional Chinese Medicine: A Case Study of Cancer Patients In Hong Kong
Authors: Pun Jack , Wong Wendy 
Published: December 2021

Abstract
Background: Traditional Chinese Medicine (TCM) is a growing phenomenon around the world. However, despite its historical role in Chinese society, there has been limited research exploring the nature of communication around cancer patients who receive TCM care in additional to conventional medicine. If TCM practitioners with adequate knowledge in understanding the needs and communication issues around patients with cancer, particularly those who simultaneously receive conventional medicine, it will lead to a better quality of care and result in better clinical outcomes such as high patient satisfaction and compliance with treatments. Objectives: To fill in this gap, this study aims to explore the nature of the communication amongst cancer patients in Hong Kong who receive TCM treatment in addition to conventional medicine. Methods: Twenty patients, 5 oncologists and 5 TCM practitioners were invited to conduct in-depth interviews to elicit their views towards their TCM treatment. A qualitative approach called Interpretative phenomenological analysis (IPA) is adopted. Results: Based on the themes that emerged from the interview transcripts, we outline the priorities of communication when dealing with cancer patients who receive both TCM and conventional medicine. A framework was developed to assist training TCM practitioners to better integrate their patients' conventional medical history when delivering patient care. Conclusion: The findings of this study can shed light to inform priorities in communication when caring for patients who opt for TCM care in addition to conventional treatments, and to provide useful information for developing future clinical research of providing integrated approach between TCM and conventional medicine in treating cancer patients.
Coherent Photonic Terahertz Transmitters Compatible with Direct Comb Modulation
Authors: Gonzalez-Guerrero Luis , Carpintero Guillermo 
Published: December 2021

Abstract
We present a novel approach to coherent photonic THz systems supporting complex modulation. The proposed scheme uses a single optical path avoiding the problems of current implementations, which include: phase decorrelation, 3-dB power loss, and polarization and power matching circuits. More importantly, we show that our novel approach is compatible with direct modulation of the output of an optical frequency comb (i.e., not requiring the demultiplexing of two tones from the comb), further simplifying the system and enabling an increase in the transmitted RF power for a fixed average optical power injected into the photodiode (PD).
An Artificial Intelligence Pipeline for Diagnosing Hepatocellular Carcinoma Patients with Bile Duct Tumor Thrombus
Authors: Liu Jinming , Wu Jiayi , Liu Anran , Bai Yannan , Zhang Hong , Yan Maolin 
Published: December 2021

Abstract
Background and purpose: Preoperative diagnosis of bile duct tumor thrombus (BDTT) is clinically important as the surgical prognosis of hepatocellular carcinoma (HCC) patients with BDTT is significantly different from that of patients without BDTT. The preoperative diagnosis of BDTT is usually based on identification of dilated bile ducts (DBDs) on medical images (eg., CT and MRI images). However, it is easy for doctors to ignore DBDs when reporting the imaging scan result, leading to a high misdiagnosis rate in practice. The aim of the present study was to develop an artificial intelligence (AI) pipeline for diagnosing HCC patients with BDTT using medical images. Methods: The proposed AI pipeline included two stages. First, the object detection neural network Faster R-CNN was adopted to identify DBDs; then, an HCC patient was diagnosed to have BDTT if the proportion of images with at least one identified DBD exceeds some threshold value. Four-fold cross validation was used to evaluate the performance of the proposed AI pipeline. Results: The proposed AI pipeline was applied on a real dataset consisting of CT images collected from 34 HCC patients (16 with BDTT and 18 without BDTT). The average true positive rate for identifying DBDs per patient was 0.92, while the patient-level true positive rate for diagnosing BDTT was 0.94. The AUC value of patient-level diagnosis of BDTT was 0.92 (95% CI: 0.83, 1.00), compared with 0.71 (95% CI: 0.52, 0.89) by random forest. Conclusions: This study first proposes an AI pipeline to identify DBDs and diagnose BDTT, and the high accuracies demonstrate that it is successful in the diagnosis of BDTT.
Do Canadians Support Tailored And Targeted Public Health Programs? A Discrete Choice Experiment
Authors: Card Kiffer G. , Adshade Marina , Hogg Robert S. , Jollimore Jody , Lachowsky Nathan J. 
Published: December 2021

Abstract
Background. We aimed to assess public support of tailored and targeted public health interventions for various marginalized communities. Methods. We conducted a discrete choice experiment using a web-based survey advertised to Facebook and Instagram users living in Canada, aged >16. Participants were asked to choose between funding two hypothetical public health programs. Each program was described by its purpose; expected increase in life expectancy; and target group. Demographically-weighted generalized linear mixed-effects models were constructed to identify program factors associated with program selection.Results. 23,889 exercises were completed by 3,054 participants. Selected programs were less likely to focus on prevention (vs. treatment). For each 1-year increase in the marginal years of life gained, there was a 15% increase in the odds of a program being selected. Interventions tailored to marginalized communities or targeting stigmatized health conditions were less likely to be selected compared with interventions targeted to the general population or targeting chronic health conditions. Noteworthy exceptions included an increased preference for interventions aligning with the perceived needs of marginalized communities (e.g. HIV and men who have sex with men). Conclusions. Stigmatizing perceptions of health conditions and key populations likely influence public health programming preferences of Canadians. Informational campaigns highlighting disparities experienced by marginalized populations may improve support for targeted and tailored interventions.
Environmental risks and power plant suspensions
Authors: Lu Yangsiyu , Zhou Xiaoyan , Simmons Blake 
Published: December 2021

Abstract
Power sector investment is crucial to accelerate a sustainable energy transition, but not all investments are successful. To shed light on investment trends, we examine 1393 Chinese overseas electric power projects spanned around 78 countries over the past two decades. We identify 5% have been cancelled or delayed, with coal and hydro projects having much higher failure rates than solar and wind projects. We find the suspension is associated with technology-specific, georeferenced environmental risks. Coal projects located in more densely populated areas where more people are exposed to air pollutants, in countries with more fatalities from extreme weather events, and in places with environmental protests, are more likely to be suspended. Additionally, hydro projects closer to protected areas have a higher suspension rate. Our results suggest that restraining from investing in environmentally risky projects helps mitigate environmental damages and prevent financial losses due to cancellation and postponement.
The effect of stem cells in repairing growth plate injury: a systematic review and meta-analysis
Authors: Xu Xiao-long , Lu Sheng-jun , Pei Hong , Chen Shun-guang , Liao Quan-ming 
Published: December 2021

Abstract
Background: Multiple studies have focused on stem cell-based therapies for growth plate injury.However, the results are not consistent.Objectives: This systematic review and meta-analysis were performed to evaluate the effects of stem cells on growth plate healing.Methods: A detailed search of relevant studies was conducted in three databases including Pub med, Cochrane library, and Embase databases, using the following keywords: “growth plate” or “physis” AND “stem cell” from inception to November 10, 2021. The standard mean difference (SMD) and 95% confidence interval (CI) for each individual study were extracted from the original studies based on relevant data and pooled to obtain integrated estimates using random effects modeling.Results: A total of 6 studies were identified. The results demonstrated that the angular deformity in the stem cell group was significantly lower than that in the control group at 4, 8,12 and 16weeks. The length discrepancy represented the degree of shortening deformity. In the stem cell group, the shortening deformity was milder than that of the control group at 16weeks. Meanwhile, at 16 weeks after surgery, the higher histologic scores in the stem cell group indicated that stem cell can significantly improve the repair quality of growth plate.Conclusions: This systematic review and meta-analysis confirmed that stem cell improved the rehabilitation of growth plate injury. However, larger-scale studies are needed to further support these findings.
Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Authors: Abrilla Aedrian A. , Pajes A. Nico Nahar I. , Jimeno Cecilia A. 
Published: December 2021

Abstract
This systematic review aimed to compare the efficacy and tolerability of metformin extended-release (MXR) and the conventional metformin immediate-release (MIR) in adults with type 2 diabetes mellitus (T2DM). PubMed, the Cochrane Library and ClinicalTrials.gov, from database inception to 15 October 2020, and other sources were searched for randomized controlled trials (RCTs) that compared equal daily doses of MXR and MIR in adults with T2DM. Random-effects model meta-analysis was performed to obtain pooled mean difference (MD) of change from baseline for continuous outcomes (glycemic and serum lipid control and anthropometrics) and risk ratio (RR) for dichotomous outcomes (gastrointestinal and serious adverse events). Statistical analysis involving 9 published RCTs with 2609 subjects revealed that MIR was associated with better HbA1c lowering (MD 0.09% [95% confidence interval, 0.02%, 0.17%]) and serum lipid control except LDL-C lowering, while MXR reduced only the cumulative incidence of dyspepsia (RR 0.58 [0.34, 0.98]). MXR and MIR were similar in all other considered outcomes. The use of MXR over MIR among adults with T2DM was associated with statistically worse but likely clinically insignificant HbA1c lowering, similar plasma glucose lowering, and minimal improvement of metformin intolerance. This information may guide patient-physician discussions in choosing between the two formulations.
Nanoscale Infrared Spectroscopy Reveals Nanoplastics at 5000 m Depth in the South Atlantic Ocean
Authors: Weckhuysen Bert , Have Iris ten , Meirer Florian , Oord Ramon , Zettler Erik , Sebille Erik Van , Amaral-Zettler Linda 
Published: December 2021

Abstract
Millimeter- and micrometer-sized plastics are well-documented in aquatic ecosystems, but little is known about sub-micrometer particles because conventional analytical techniques lack sufficient spatial resolution or the spectroscopic means to unambiguously identify individual nanometer-sized plastic particles. We combined the spatial resolution of atomic force microscopy with chemical information from infrared spectroscopy to detect, identify, and count nanoplastics down to 20 nm in diameter in samples from different depths in the South Atlantic Ocean. We present evidence for the presence of polyethylene terephthalate (PET) nanoplastics in different states of degradation at 5000 m. Using lab-based ageing of PET, we demonstrate that nanoplastics can form even without light or interaction with the plastisphere, and that macroscopic PET items are a plausible source of PET nanoplastics in the ocean.
First Isolation of Leptospira Borgpetersenii Serovar Hardjobovis in Guanacos (Lama Guanicoe) in South America
Authors: Brihuega Bibiana , Saraullo Vanina , Martinez Mara , Watanabe Olivia , Hamer Micaela , Loffler Sylvia Grune 
Published: December 2021

Abstract
Background

Leptospirosis is the most widespread zoonotic disease in the world. It is caused by pathogenic spirochetes of the genus Leptospira spp. and is maintained in nature through chronic renal infection of carrier animals, being rodents and other small mammals the main reservoirs. This bacterial genus is highly heterogeneous and divided into three clades (pathogenic, saprophyte and intermediate). Presence of pathogenic strains in wildlife populations is essential to monitor the epidemiological status of this disease worldwide.
Methods

In this study, we characterize an isolated strain of a Guanaco (Lama guanicoe) using Multiple Locus Variable number tandem repeats Analysis (MLVA) (Variable Number Tandem Repeats-VNTRs: 4, 7, 10, Lb4 and Lb5). To confirm the identity of the isolated strain, partial 16S rRNA sequencing was carried out. Phylogeny was constructed using Neighbor- joining.
Results

The pathogenic leptospiral strain isolated from Llama guanicoe had the genetic profile identical to L. borgpetersenii serovar Hardjobovis reference strain Sponselee.
Conclusions

To the best of our knowledge, this is the first isolation and genetic characterization of a pathogenic leptospiral strain in Guanacos in South America.
Quando os museus entram no ambiente digital: atuação e usuários
Authors: Bezerra Lehi Aguiar , Andrade Elisângela Moura de 
Published: December 2021

Os avanços tecnológicos, das últimas décadas, ampliaram as possibilidades de disseminação da informação através da diversificação dos suportes disponíveis, principalmente no meio eletrônico. Nesse contexto, não apenas as informações são alocadas nos novos espaços eletrônicos, mas as instituições começam a ocupar e a se adaptar a esses ambientes, com a finalidade de encontrar novos espaços de atuação e de potencializar seus serviços e produtos com as ferramentas da web, atraindo, dessa forma, novos usuários.
O Centro de Documentação do Museu Câmara Cascudo e o Sistema de Bibliotecas da Universidade Federal do Rio Grande do Norte:
Authors: Silva Igor Oliveira , Tanus Gabrielle Francinne 
Published: December 2021

Resumo: Apresenta a trajetória do Museu Câmara Cascudo e a potencialidade do acervo documental e bibliográfico, que compõe o centro de documentação da instituição, e que serve como fonte para o desenvolvimento de diversas pesquisas. As pesquisas de extensão que envolvem o Museu também foram levantadas a fim de mostrar o enlace com a comunidade e a efetivação da tríade da Universidade – ensino, pesquisa, e extensão. Evidencia-se a importância do centro de documentação do Museu Câmara Cascudo em integrar o Sistema de Biblioteca Universitária da Universidade Federal do Rio Grande do Norte (UFRN), tendo em vista que o museu está vinculado a esta instituição de ensino superior. A partir da entrevista com os gestores das instituições, do Museu e da Biblioteca Universitária, como também com o servidor arquivista, buscou-se expor e compreender o porquê da não efetivação do museu dentro do Sistema de Bibliotecas. Ademais destaca-se a importância e as consequências da ausência do bibliotecário em um dos principais museus do estado do Rio Grande do Norte.
Palavras-chaves: Museu Câmara Cascudo. Centro de Documento. Sistema de Bibliotecas. Universidade Federal do Rio Grande do Norte.