bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors and outcomes of gastrointestinal bleeding in patients with stable coronary artery disease: data from the observational registry of long-term antithrombotic therapy REGATTA-1
Authors: Komarov A. L. , Shakhmatova O. O. , Korobkova V. V. , Novikova E. S. , Guskova E. V. , Yarovaya E. B. , Balachonova T. V. , Shuleshova A. G. , Panchenko E. P. 
Published: July 2021

Aim. To optimize the upper gastrointestinal bleeding (UGIB) risk scale in patients Material and methods. The UGIB risk scale was developed based on the with chronic coronary artery disease (CAD) receiving long-term antiplatelet therapy. prospective REGistry of long-term AnTithrombotic TherApy-1 REGATTA-1(ClinicalTrials.gov Identifier: NCT04347200). The registry includes 934 patients with stable CAD (men, 78,6%; median age, 61±10,7 years), 76% of whom were included after elective percutaneous coronary interventions and received dual antiplatelet therapy for 6-12 months. After a UGIB episode, patients were prescribed proton pump inhibitors. The 2015 European Society of Cardiology (ESC) scale was used for assessing the UGIB risk. In addition, we evaluated the ultrasound data on atherosclerotic burden (abdominal aorta and peripheral arteries).Results. The median follow-up was 2,5 years [1,1-14,7 years]. The incidence of UGIB was 1,9 cases per 100 patient/years. Recurrent UGIB episodes and thrombosis was recorded in 13,7% and 31,4%, respectively. Based on the results of a multivariate logistic regression, a novel scale for assessing the UGIB risk (REGATTA) has been developed. In accordance with the odds ratio, points were assigned for each independent risk factor (RF): age ≥80 years — 3 points, prior gastric erosion, peptic ulcer disease or UGIB — 3 points for each RF, anticoagulation therapy — 4 points, non-steroidal antiinflammatory drug therapy — 2 points. The atherosclerotic burden (peripheral atherosclerosis and/or abdominal aortic aneurysm; 2 points) and heart failure (in most cases after a myocardial infarction; 2 points) were marked as a new independent predictor. The cutoff value (≥4 points) was determined, reflecting the high UGIB risk (sensitivity, 80,4%; specificity, 84,5%). The REGATTA scale was more powerful than the traditional 2015 ESC scale: AUC of 0,88, (95% confidence interval, 0,86-0,9) vs AUC of 0,79, (95% confidence interval, 0,760,82) (p=0,04).Conclusion. The identified UGIB predictors (atherosclerotic burden and heart failure) and the developed REGATTA scale made it possible to improve the prognosis and prevention of UGIB in patients with stable CAD receiving long-term antiplatelet therapy.
Biology and Conservation of the Freshwater Turtles and Tortoises of Peru
Authors: Ferronato Bruno O. , Morales Victor M. 
Published: July 2021

Little information has been published on Peruvian chelonians. Here we have compiled the available literature pertaining to Peruvian freshwater turtles and tortoises on four topics: Human consumption and ethnobiology, habitat use, status and abundance, and reproduction. In addition, we provide a map of the regions of Peru showing the number of research records and the number of species that occur in each region. Reproduction was the topic most frequently studied, although investigations were concentrated on only three species (Podocnemis unifilis, P. expansa, P. sextuberculata). The regions where the most studies were implemented are the Departamentos de Loreto and Madre de Dios, with studies tending to be concentrated in the vicinity of Iquitos, the Pacaya-Samiria National Reserve, and Manu National Park and its buffer zone. In general, regions in which more research effort was evident reported more turtle species, which suggests that the least-studied states could have more species, as they share the same types of habitats as the more intensely investigated regions. We identified major gaps in information and suggest future research in the following poorly studied Peruvian regions: Departaments of Junín, San Martín, Tumbes, Huanuco, Amazonas, Cusco, Ayacucho, Puno, Huancavelica, and Cajamarca. The status, distribution, and abundance of Peruvian populations of Podocnemis expansa, P. unifilis, Chelonoidis carbonaria, Peltocephalus dumerilianus, and Mesoclemmys heliostemma are in particular need of study. Conservation priorities are also discussed.
Urban Amphibians of the Texas Panhandle
Authors: Ramesh Rasika , Griffis-Kyle Kerry , Perry Gad , Farmer Michael 
Published: July 2021

Habitat loss, degradation, and fragmentation due to urbanization are implicated in amphibian declines worldwide. Conservation efforts require information on resident species and their habitat interactions, but amphibian ecology is largely unstudied in urban centers of the Southern High Plains. Here, we gathered baseline data on amphibian presence, species richness, and habitat preferences at site-specific and landscape scales during a severe drought year in the city of Lubbock, in northwestern Texas. Ephemeral playa wetlands are characteristic of this landscape. During urbanization, these have been extensively modifiied for stormwater drainage, agriculture, and construction of roads, buildings and neighborhoods. A semi-arid climate with frequent droughts, together with urbanization, could have an adverse effect on resident amphibians. In 2011, we sampled 23 urban lakes for amphibian presence, using a combination of audio, visual, and larval surveys. We detected five amphibian species at seven lakes; Texas Toads (Anaxyrus speciosus) and Spotted Chorus Frogs (Pseudacris clarkii) were the most frequently encountered species. We found significant negative effects of nearby road density on amphibian species presence and richness. We also detected significant negative effects of basic pH on amphibian species richness. These data can be used for prioritizing lakes for amphibian conservation strategies, to monitor ecosystem function in urban wetlands, and to guide future development and restoration efforts.
Program remedial dan angka putus studi mahasiswa kedokteran
Authors: Wahab Revalita , Tjhin Purnamawati 
Published: July 2021

Latar Belakang
Walaupun penyusunan kurikulum Pendidikan Kedokteran telah disusun sedemikian rupa supaya dapat menghasilkan lulusan yang memiliki kompetensi yang ditetapkan, tetap ada mahasiswa yang mengalami putus studi. Prevalensi putus studi tahun 2017 sebesar 2,8% di Indonesia dan 3,7% di Jakarta. Putus studi dapat berdampak negatif untuk masyarakat, profesi dan institusi, sehingga perlu upaya untuk melakukan pencegahan dan penanggulangannya. Salah satu upaya yang dapat dilakukan adalah dengan program remedial. Penelitian ini bertujuan untuk menilai efektifivitas program remedial dalam menurunkan angka putus studi mahasiswa kedokteran.
Metode

Penelitian dilakukan dengan desain cross-sectional pada 228 mahasiswa angkatan 2013-2017, menggunakan data sekunder meliputi jenis kelamin, tahun masuk kuliah, dan status putus studi. Kriteria inklusi sampel adalah mahasiswa yang termasuk pada kategori terancam putus studi. Analisis data dengan uji Chi-square, dengan tingkat kemaknaan 95%.

Hasil
Prevalensi putus studi sebesar 12,7%. Sebagian besar responden yang terancam putus studi berjenis kelamin perempuan (68,9%) dan merupakan mahasiswa program non remedial (64%). Tidak ada perbedaan bermakna antara jenis kelamin dan angka putus studi (p=0,989). Perempuan dan laki-laki memiliki peluang yang sama untuk terjadi putus studi. Mahasiswa yang termasuk angkatan program remedial memiliki angka putus studi yang lebih tinggi (18,3%) dibandingkan dengan mahasiswa yang termasuk angkatan non-remedial (9,6%), walaupun secara statistik tidak bermakna (p=0,058).

Kesimpulan
Prevalensi putus studi mahasiswa kedokteran tahun 2013-2017 sebesar 12,7%. Tidak terdapat hubungan bermakna antara jenis kelamin dan program remedial dengan terjadinya putus studi.
Management of Autoimmune Hemolytic Anemia in the Midst of Coronavirus Disease 2019 Pandemic: A Case Report
Authors: Kurniawan Andree , Halim Devina Adella 
Published: July 2021

<p><strong>Introduction : </strong>The novel coronavirus disease 2019 (COVID-19) has become a pandemic involving all people and can be severe and life-threatening in a certain population such as those with comorbidity. Autoimmune hemolytic anemia (AIHA) is an autoimmune hematologic disease characterized with antibodies production that binds to red cell surface antigens. In this pandemic, several concerns have been raised by autoimmune disease clinicians and patients regarding the use of immunosuppressive drugs. In this case report, we illustrate the problems of autoimmune hemolytic anemia patient when she got active case.</p><p><strong>Case Illustration : </strong>A 28 years old lady was admitted to the hospital owing to fatigue and tiredness during exercise for two weeks. She had been diagnosed with autoimmune hemolytic anemia before and did not comply with the treatment. This patient has been reevaluated of having AIHA from the symptoms of fatigue, enlarged spleen, low hemoglobin, increased reticulocytes, signs of hemolytic in blood smear examination, increased indirect bilirubin, LDH and the Combs’ test result was given positive. She received methylprednisolone 2 mg/kg of body weight intravenously, washed packed red cells (PRC), calcium and proton pump inhibitor. She was discharged at the seventh day since admission and she was prescribed oral methylprednisolone equal to 1 mg/kg body weight.</p><p><strong>Conclusion : </strong>This is an educated case of non-compliance of AIHA that should be given high dose steroid and blood transfusion during hospitalization amid the COVID-19 pandemic. The recommendation of treatment for AIHA was still the same as before the pandemic occured.</p>
Advertising activities of research libraries in the period of pandemic
Authors: Mammadova K. A. 
Published: July 2021

The article examines the advertising activities of scientific libraries during the pandemic period, including the role and importance of advertising in the process of promoting library and information services and products. The author notes that advertising allows to reach a wider audience in a short time, to increase the efficiency and quality of the service process and to ensure the stability of the library position in the society.Advertising can create a stable information demand for definit library and information services and products. The article also touches questions of SMM (Social Media Marketing) usage in libraries.It is emphasized that SMM is a solution for marketing issues of the library through social networks. Its main purpose is to provide the profile audience with information about the library’s services and products in the form of feedback, communication with the user and exchange of their views, as well as to encourage them to use the library resources as a whole. The advantage of using SMM instruments is the possibility to attract more users. The author also studied the activities of one of the largest Azerbaijani libraries during the pandemic and came to the conclusion that in the current situation on the information market, the leader-ship of publishing and bookselling enterprises with advertizing services and products is obvious. In this connection such coordination of libraries with these enterprises can support and maintain the position of the library in the society.
Measurable Thoracic Motion Remains at 1 Year Following Anterior Vertebral Body Tethering, with Sagittal Motion Greater Than Coronal Motion
Authors: Buyuk Abdul Fettah , Milbrandt Todd A. , Mathew Smitha E. , Larson A. Noelle 
Published: July 2021

Background:
Anterior vertebral body tethering is an alternative to fusion surgery for the treatment of adolescent idiopathic scoliosis (AIS) that is purported to preserve spinal motion. There is limited information regarding the measurable motion that is maintained over the instrumented levels following thoracic anterior vertebral body tethering surgery in humans. The purpose of the present study was to assess radiographic spinal motion 1 year after anterior vertebral body tethering.

Methods:
As part of a prospective U.S. Food and Drug Administration investigational device exemption study, 32 patients were treated with thoracic anterior vertebral body tethering. At 1 year postoperatively, patients were evaluated with standing flexion-extension and side-bending radiographs in a microdose biplanar slot scanning imaging system. The angle subtended by the screws at the upper instrumented vertebra (UIV) and lower instrumented vertebra (LIV) was measured on left and right-bending radiographs to evaluate the coronal arc of motion and was compared with preoperative values over the same levels. At 1 year postoperatively, the sagittal Cobb angle was measured over the instrumented levels on flexion and extension radiographs.

Results:
Side-bending radiographs revealed that the mean angle subtended by the screws changed from 15° ± 8° on left-bending radiographs to 8° ± 6° on right-bending radiographs. The mean coronal arc of motion on bending was 7° ± 6°, with 20 (62.5%) of 32 patients having a coronal arc of motion of >5°. The mean preoperative coronal arc of motion over the instrumented segments was 30° ± 9°. On flexion-extension lateral radiographs made at 1 year postoperatively, the mean kyphotic angle over the instrumented segments was 33° ± 13° in flexion and 11° ± 14° in extension, for a mean postoperative arc of motion of 21° ± 12° between flexion and extension radiographs.

Conclusions:
At 1 year following thoracic anterior vertebral body tethering for the treatment of AIS, the thoracic spine showed a measurable range of coronal and sagittal plane motion over the instrumented levels without evidence of complete autofusion. Motion in the coronal plane decreased by 77% following anterior vertebral body tethering. These findings provide proof of concept that sagittal spinal motion is preserved after thoracic anterior vertebral body tethering, although the functional importance remains to be determined.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Diagnosis and Management of Unstable Slipped Capital Femoral Epiphysis
Authors: Cazzulino Alejandro , Wu Wei , Allahabadi Sachin , Swarup Ishaan 
Published: July 2021

» An unstable slipped capital femoral epiphysis (SCFE) is characterized by the inability to walk and is associated with a high risk of osteonecrosis.» An unstable SCFE is less common than a stable SCFE; however, the demographics are similar in both groups of patients with SCFE.» The diagnosis of an unstable SCFE is characterized by a history of antecedent pain and the inability to walk on examination, and it is confirmed by radiographic assessment.» Management of an unstable SCFE includes closed reduction, open reduction, and capital realignment, which have all been noted to have lower rates of osteonecrosis than reported in historic reports.» All management approaches have certain advantages and disadvantages, and comparative studies are needed to guide clinical decision-making.
Wound Dressings for Hip and Knee Total Joint Arthroplasty
Authors: Rothfusz Christopher A. , Emara Ahmed K. , McLaughlin John P. , Molloy Robert M. , Krebs Viktor E. , Piuzzi Nicolas S. 
Published: July 2021

» Dressing choice following lower-extremity total joint arthroplasty has substantial ramifications for postoperative outcomes and should be carefully made to prevent complications such as periprosthetic joint infection.» Patient risk factors are essential components in the selection of wound dressings in total joint arthroplasty.» Traditional dressings are inexpensive per unit; nevertheless, the associated higher complication profile in patients at a high risk for poor wound healing and sequelae-associated costs may outweigh the up-front savings.» Modern dressings have the potential to yield better safety outcomes and increased patient satisfaction; however, there is a paucity of evidence regarding the ideal interactive dressing.» Active dressings, such as silver-ion dressings and closed-incisional negative-pressure wound therapy, have shown promising results to reduce surgical site and periprosthetic joint infection, especially in patients at a high risk for poor wound healing following hip and knee total joint arthroplasty.
Ziprasidone Suppresses Pancreatic Adenocarcinoma Cells Proliferation by Targeting GOT1 to Trigger Glutamine Metabolism Reprogramming
Authors: Yang Yueying , Han Fei , Li Mingxue , Zheng Mengzhu , Gu Xiaoxia , Li Hua , Chen Lixia 
Published: July 2021

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant tumor that no effective treatment has been found. The redox state and proliferative activity of PDAC cells are maintained by the conversion of aspartic acid in the cytoplasm into oxaloacetate though aspartate aminotransferase 1 (GOT1). Therefore, GOT1 inhibitors as a potential approach for treating PDAC have attracted more attention of researchers. Ziprasidone effectively inhibited GOT1 in a non-competitive manner. The potential cytotoxicity and anti-proliferation effects of ziprasidone against PDAC cells in vitro and in vivo were evaluated. Ziprasidone can induce glutamine metabolism disorder and redox state imbalance of PDAC cells by targeting GOT1, thereby inhibiting proliferation, preventing migration and inducing apoptosis. Ziprasidone displayed significant in vivo antitumor efficacy in SW1990 cell-derived xenografts. What’s more, knockdown of GOT1 in SW1990 reduced the anti-proliferative effects of ziprasidone. As a novel GOT1 inhibitor, ziprasidone may be a lead compound for the treatment of PDAC.
Vaccination for Patients with Inborn Errors of Immunity: A Nationwide Survey in Japan
Authors: Hosaka Sho , Kido Takahiro , Imagawa Kazuo , Fukushima Hiroko , Morio Tomohiro , Nonoyama Shigeaki , Takada Hidetoshi 
Published: July 2021

Abstract
We conducted a nationwide survey of inborn errors of immunity (IEI) in Japan for the second time in 10 years, focusing on protective measures for IEI patients against infectious diseases. Questionnaires were sent to various medical departments nationwide, and a total of 1,307 patients were reported. The prevalence of IEI was 2.2 patients per 100,000 population which was comparable with the previous nationwide study. The most common disease category was autoinflammatory disorders (25%), followed by antibody deficiencies (24%) and congenital defects of phagocyte number or function (16%). We found that a significant number of patients received contraindicated vaccines, principally because the patients were not diagnosed as IEI by the time of the vaccination. Regarding diseases for which BCG vaccination is contraindicated, 43% patients had actually received BCG, of which 14% developed BCG related infections. In order to prevent IEI patients from receiving inadequate vaccines, the continuous education to parents and physicians is needed, along with the expansion of newborn screening, but efforts to screen IEI at the site of vaccination also remains important.
Obesity and Diabetes as Main Risk Factors for Stillbirth in a Population from Northeastern Mexico
Authors: Espinoza Kiabeth Robles , Uriarte Graciela Arelí López , Castañeda Gloria Beatriz García , Muñoz Iris Torres , Trampe José de Jesús Lugo , Riojas Guillermo Elizondo , Quintana Oralia Barboza , Camacho Marco Ponce , López Abel Guzmán , de Villareal Laura Martínez 
Published: July 2021

Abstract
Purpose

Stillbirth is an important health problem in obstetrics practice. In Mexico, half of the stillbirths have an explainable cause. The aim of this study was to detect potential stillbirth risk factors and etiology by implementing a multidisciplinary workup at the Hospital Universitario “Dr. José Eleuterio González”.

Methods

This is a prospective, descriptive, observational study that included stillbirths from the Obstetrics Service from October 1st, 2019 to May 25, 2020. Evaluation strategies included a complete maternal medical history, physical examination of the fetus, and a photographic medical record. A stillbirth needed to have either a prenatal ultrasound, or a postnatal x-ray, and if possible, a fetal autopsy. Multiplex Ligation Probe Amplification (MLPA) was performed with an umbilical cord sample.

Results

Thirty-three stillbirths were reported; 21 were included in the analysis. Eleven mothers (52.3%) had known risk factors for stillbirth, mainly elevated body mass index and diabetes. On physical examination, external birth defects were found in 8 fetuses (38%). X-ray was performed in 14 cases (66%). Alterations were detected as a probable etiologic cause just in one. All cases underwent MLPA, which were reported negative. Three cases had criteria for autopsy. Findings were inconclusive to determine etiology.

Conclusion

Diabetes and obesity were the most frequent risk factors associated with stillbirth in this Mexican population. These factors are preventable by implementing strategies that lead to better prenatal care.
Prognostic Factors for Elderly Gastric Cancer Patients who Underwent Gastrectomy
Authors: Endo Shunji , Yamatsuji Tomoki , Fujiwara Yoshinori , Higashida Masaharu , Kubota Hisako , Matsumoto Hideo , Tanaka Hironori , Okada Toshimasa , Yoshimatsu Kazuhiko , Sugimoto Ken , Ueno Tomio 
Published: July 2021

Abstract
Background: Patients with gastric cancer are aging in Japan. It is not clear which patients and which surgical procedures have survival benefits after gastrectomy. A multivariate analysis was performed.Methods: The medical records of 166 patients aged ≥80 years who underwent gastrectomy without macroscopic residual tumors were retrospectively reviewed. Univariate and multivariate analyses using Cox proportional hazard models were performed to detect prognostic factors for overall survival.Results: In univariate analyses, age (≥90 vs. ≥80, <85), performance status (3 vs. 0), the physiological score of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) (≥40 vs. ≥20, ≤29), Onodera’s prognostic nutritional index (<40 vs. ≥45), American Society of Anesthesiologists physical status (ASA-PS) (3, 4 vs. 1, 2), surgical approach (laparoscopic vs. open), extent of gastrectomy (total, proximal vs. distal), extent of lymphadenectomy (D1 vs. ≥D2), pathological stage (II-IV vs. I), and residual tumor (R1 vs. R0) were significantly correlated with worse overall survival. Multivariate analysis revealed that ASA-PS [3, 4 vs. 1, 2, hazard ratio (HR) 2.30, 95% confidence interval (CI) 1.24-4.24], extent of gastrectomy (total vs distal, HR 2.17, 95% CI 1.10-4.31), (proximal vs. distal, HR 4.05, 95% CI 1.45-11.3), extent of lymphadenectomy (D0 vs. ≥D2, HR 12.4, 95% CI 1.58-97.7) and pathological stage were independent risk factors for mortality.Conclusions: ASA-PS was a useful predictor for postoperative mortality. Gastrectomy including cardia and excessive limitation of lymphadenectomy are best avoided.