bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Subdivision Automatic Control Precision Spraying
Authors: Hu Minying , Sang Yongying , Cai Jinjin , Liu Shangkun , Kong Degang 
Published: February 2021

Abstract
In this paper, based on the fact that is still a small peasant economy in China and there are many small plots, this article studies small and medium sprayers. In this sprayer, the subdivision precision spraying control system, designed for precision agriculture applications, was simulated by the LabVIEW software, while an experimental setup was able to measure and record during laboratory experiments. The main pipeline of sprayer chose the A and B. And the two different pipelines were set in the different target spray volume. When the theoretical spray value was kept being unchanged, the flow rate was verified with the field sprayer speed which were set by the pulse generator. With that the pressure stability test was completed. Based on the analysis and experimental results, the flow control precision is 97.03%, and the pressure stability precision is 97.88%, the relative average of the pulse generator is 0.05. Finally, the subdivision system could control the flow of the two branches and was better than the traditional spray method in China, while it could achieve more precise control of spray.
ChemFET sensor: Repercussion of Swift Heavy Ion irradiation on nanorods of nickel-based (NRs-Ni3HHTP2) Metal-Organic framework
Authors: Ingle Nikesh N. , Sayyad Pasha , Bodkhe Gajanan , Patil Harshada , Deshmukh Megha , Mahadik Manasi , Shirsat Sumedh , Singh Fouran , Shirsat Mahendra 
Published: February 2021

Abstract
Repercussion of Swift Heavy Ion (SHI) irradiation on nickel-based nanorods of Metal-Organic Framework (NRs-Ni3HHTP2-MOF) for enhancement in the properties of ChemFET based gas sensor has been investigated. Nanorods of Ni3HHTP2-MOF were synthesized by chemical method and exposed to C12+ ions irradiation with fluence 1x1011 ion/cm2 and 1x1012 ion/cm2. The structural, spectroscopic morphological and optical characterizations were carried out using x-ray diffraction (XRD), fourier transfer infrared spectroscopy (FTIR), atomic force microscopy (AFM) with scanning electron microscopy (SEM) and UV-visible spectroscopy were studied respectively. Whereas the bandgap was calculated from Tauc's plot. The synthesized nanorods of Ni3HHTP2 MOF were drop-casted on gold coated microelectrodes on silicon/silicon dioxide (Si/SiO2) substrate, where silicon layer serves as a gate and gold microelectrodes on silicon/silicon dioxide (Si/SiO2) substrate as a source and drain. The transmutations in material properties due to SHI irradiations were serviceable for enhancing field-effect transistor (transfer and output) properties.
Quaternary Ammonium Salts Based on (-)-Borneol as Effective Inhibitors of Influenza Virus
Authors: Sokolova Anastasiya , Yarovaya Olga , Baranova Darya , Galochkina Anastasiya , Kireeva Marina , Shtro Anna , Borisevich Sophia , Gatilov Yuriy , Zarubaev Vladimir , Salakhutdinov Nariman 
Published: February 2021

Abstract
A new compounds containing 1,7,7-trimethylbicyclo[2.2.1]heptane fragment has been found to exhibit potent inhibitory activity against the influenza A(H1N1) virus. The most potent antiviral compound 10a is a quaternary ammonium salt based on (-)-borneol, with a therapeutic index of more than 500. Mechanism-of-action studies for compound 10a were performed. The compound appeared the most effective when added at the early stages of viral life cycle. In direct hemagglutinin inhibition tests the agent, 10a, was shown to decrease the activity of hemagglutinin of influenza virus A/Puerto Rico/8/34. According to the results of molecular modelling, the lead-compound, 10a, can attach at the binding sites of the stem part of the HA. These results prove that monoterpenoids with 1,7,7-trimethylbicyclo[2.2.1]heptane fragment are prospective natural compounds for the development of antiviral agents.
Late Holocene Sedimentation Dynamics in the Lake Ulaan Basin, Southern Mongolia: A History of a Playa Lake&nbsp;
Authors: Orkhonselenge Alexander , Uuganzaya Munkhjargal , Davaagatan Tuyagerel 
Published: February 2021

Abstract
Sedimentation dynamics in the Lake Ulaan basin located in the northern margin of the Govi region, southern Mongolia show high sedimentation rates of 11.8–22.7 cm/ka in the eastern part of the basin and low rates of 3.3–5.8 cm/ka in the western part during the late Holocene. The eastern and western parts of the lake have been strongly influenced by fluvial and aeolian activities since the arid late Holocene. However, fluvial sediment input was more significantly recorded in the eastern part. Aeolian deflation has been prevailing throughout the lake bank recently. Lake Ulaan reached its maximum extent before the early Holocene (Sternberg and Paillou, 2015; Holguin and Sternberg, 2016) with a water depth of ~43 m (Lehmkuhl et al., 2018a). After the early Holocene, Lake Ulaan started to decrease its area, and the drop of the lake level intensified since the middle Holocene. In the late Holocene, the лйоупы western and eastern parts were initially exposed to wind deflation at 2.7–3.2 cal. ka BP and the aerial exposition continued at 0.6–1.3 cal. ka BP. In the Anthropocene, Lake Ulaan has rapidly shifted into a playa lake condition during the last five to six decades, and it has become an open-source area of dust generation blown out by the westerly winds.
Prediction of GOLD Stage in Patients Hospitalized with COPD Exacerbations Using Blood Neutrophils and Demographic Parameters as Risk Factors
Authors: Chen Jing , Zhao Yang , Qun Yuan , Liquan Guo , Daxi Xiong 
Published: February 2021

Abstract
Background: Patients hospitalized with chronic obstructive pulmonary disease (COPD) exacerbations are unable to complete the pulmonary function test reliably due to their poor health conditions. Creating an easy-to-use instrument to identify the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage will offer valuable information that assists clinicians to choose appropriate clinical care to decrease the mortality in these patients. The objective of this study was to develop a prediction model to identify the GOLD stage in the hospitalized exacerbation of chronic obstructive pulmonary disease (ECOPD) patients.Methods: This study involved 155 patients hospitalized for ECOPD. All participants completed lung function tests and the collection of blood neutrophils and demographic parameters. Receiver operating characteristic (ROC) curve was plotted based on the data of 155 patients, and was used to analyze the disease severity predictive ability of blood neutrophils and demographic parameters. A support vector regression (SVR) based GOLD stage prediction model was built using the training data set (75%), whose accuracy was then verified by the testing data set (25%).Results: The percentage of blood neutrophils (denoted as NEU%) combined with the demographic parameters was associated with a higher risk to severe episode of ECOPD. The area under the ROC curve was 0.84. The SVR model managed to predict the GOLD stage with an accuracy of 90.24%. The root-mean-square error (RMSE) of the forced expiratory volume in one second as the percentage of the predicted value (denoted as FEV1%pred) was 8.84%. Conclusions: The NEU% and demographic parameters are associated with the pulmonary function of the hospitalized ECOPD patients. The established prediction model could assist clinicians in diagnosing GOLD stage and planning appropriate clinical care.
A case for improved assessment of gut permeability – a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn’s disease
Authors: Gan Jonathan , Nazarian Scarlet , Teare Julian , Darzi Ara , Ashrafian Hutan , Thompson Alex J. 
Published: February 2021

Abstract
Background
A widely used method in assessing small bowel permeability is the lactulose:mannitol test, where the lactulose:mannitol ratio (LMR) is measured. However, there is discrepancy in how the test is conducted and in the values of LMR obtained across studies. This meta-analysis aims to determine LMR in healthy subjects, coeliac and Crohn’s disease.
Methods
A literature search was performed using PRISMA guidance to identify studies assessing LMR in coeliac or Crohn’s disease. 19 studies included in the meta-analysis measured gut permeability in coeliac disease, 17 studies in Crohn’s disease. Outcomes of interest were LMR values and comparisons of standard mean difference (SMD) and weighted mean difference (WMD) in healthy controls, inactive Crohn’s, active Crohn’s, treated coeliac and untreated coeliac. Pooled estimates of differences in LMR were calculated using the random effects model.
Results
Pooled LMR in healthy controls was 0.014 (95% CI: 0.006–0.022) while pooled LMRs in untreated and treated coeliac were 0.133 (95% CI: 0.089–0.178) and 0.037 (95% CI: 0.019–0.055). In active and inactive Crohn’s disease, pooled LMRs were 0.093 (95% CI: 0.031–0.156) and 0.028 (95% CI: 0.015–0.041). Significant differences were observed in LMR between: (i) healthy controls and treated coeliacs (SMD = 0.409 95% CI 0.034 to 0.783, p = 0.032), (ii) healthy controls and untreated coeliacs (SMD = 1.362 95% CI: 0.740 to 1.984, p < 0.001), (iii) treated coeliacs and untreated coeliacs (SMD = 0.722 95% CI: 0.286 to 1.157, p = 0.001), (iv) healthy controls and inactive Crohns (SMD = 1.265 95% CI: 0.845 to 1.686, p < 0.001), (v) healthy controls and active Crohns (SMD = 2.868 95% CI: 2.112 to 3.623, p < 0.001), and (vi) active Crohns and inactive Crohns (SMD = 1.429 (95% CI: 0.580 to 2.278, p = 0.001). High heterogeneity was observed, which was attributed to variability in protocols used across different studies.
Conclusion
The use of gut permeability measurements in screening and monitoring of coeliac and Crohn’s disease is promising. LMR is useful in performing this function with significant limitations. More robust alternative tests with higher degrees of clinical evidence are needed if measurements of gut permeability are to find widespread clinical use.
Trial Registration
Not Applicable
Comparison of obesity-related parameters as predictors of high brachial-ankle pulse wave velocity in middle-aged and elderly people in China: A multicenter cross-sectional community-based study
Authors: Sun Ting , Xie Hui , Ma Zuchang 
Published: February 2021

Abstract
Background

The association between obesity-related parameters and occurrence of high brachial-ankle pulse wave velocity (baPWV) in Chinese middle-aged (40–59 years) and elderly people (≥ 60 years) is unknown, especially when body composition indicators are compared.
Methods

A total of 3219 middle-aged and elderly subjects who were recruited from 6 community health service centers located in Hefei, Bengbu, and Chuzhou (Anhui province, Eastern China) met the inclusion criteria and had valid data. An e-health promotion system was used to collect basic health data, and baPWV and the body composition of each subject were measured. Partial correlation and binary logistic regression analyses were performed to identify associations between obesity-related parameters and high baPWV, and receiver operating characteristic (ROC) curves were analyzed to determine the optimal cutoff values and predictive capacity of high baPWV.
Results

Partial correlation coefficients (adjusted for age and mean arterial pressure) for waist-to-height ratio (WHtR) (0.101 and 0.192) and waist circumference (WC) (0.101 and 0.172) were highest in women. The partial correlation coefficient for fat tissue index (0.158) was highest in middle-aged men. WHtR combined covariates explained the largest proportion of the variance for dependent variables in model 1, model 2 (women), and model 3 (women). R2 ranged from 0.088 to 0.216 in Model 1. The predictive capacities of these parameters were lower in men. The area under the ROC curve was higher for WHtR (0.647–0.739) than other parameters in elderly women, with optimal cutoff values of 0.52.
Conclusions

WHtR and WC may be useful for community-based screening of women as a secondary preventative measure for high baPWV. These 2 parameters can be used in conjunction with others (eg, body composition index) to predict the risk of high baPWV based on region, age, and sex.
Electrolyte Modulators towards Polarization Immune Lithium-Ion Batteries for Sustainable Electric Transportation
Authors: Li Xinru , Xu Pengcheng , Tian Yue , Fortini Alexis , Choi Seungho , Liu Xiaoyan , Xu Jinhui , Liu Qian , Wu Hao Bin , Chen Gen , Zhang Chen , Tan Xinyi , Jin Lihua , Wang Qinchao , Shen Li , Lu Yunfeng 
Published: February 2021

Abstract
Lithium-ion batteries for electric vehicles (EV) are subject to fast charging, dynamic acceleration, and regenerative braking. However, the polarization arises from these high-rate operations and tends to deteriorate the battery performance and therefore the driving range and lifespan of EVs. Using metal organic frameworks (MOF) as electrolyte modulators (MEM), we report herein a facile strategy for effective mitigation of polarization, where the MEM can confine anions and enrich electrolyte, affording boosted lithium-ion transference number (up to 0.76) and high ionic conductivity (up to 9 mS cm−1). In addition, such MEM could implant itself into electrolyte interface, conferring the interface with low-resistance and ability to suppress concentration polarization. As a result, commercial cells with MEM deliver remarkably enhanced power output, energy efficiency, and lifespan during high rate (2C, > 3000 cycles) as well as dynamic stress tests (tripled cycle life) that mimic realistic operation of EV. This work introduces a readily implementable approach towards optimizing ion transport in electrolyte and developing polarization immune battery for power-intensive applications.
Modeling gene x environment interactions in PTSD using glucocorticoid-induced transcriptomics in human neurons
Authors: Breen Michael , Breen Michael , Rusielewicz Tom , Bader Heather , Seah Carina , Wu Changxin , Hunter Christopher , McCarthy Barry , Chattopadhyay Mitali , Desarnaud Frank , Makotkine Iouri , Flory Janine , Staniskyte Migle , Noggle Scott , Paull Daniel , Brennand Kristen , Yehuda Rachel 
Published: February 2021

Abstract
Post-traumatic stress disorder (PTSD) results from severe trauma exposure, but the extent to which genetic and epigenetic risk factors impact individual clinical outcomes is unknown. We assessed the impact of genomic differences following glucocorticoid administration by examining the transcriptional profile of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons and live cultured peripheral blood mononuclear cells from combat veterans with PTSD (n=5) and without PTSD (n=5). This parallel examination in baseline and glucocorticoid-treated conditions resolves cell-type specific and diagnosis-dependent elements of stress response, and permits discrimination of gene expression signals associated with PTSD risk from those induced by stress. Computational analyses revealed neuron-specific glucocorticoid-response expression patterns that were enriched for transcriptomic patterns observed in clinical PTSD samples. PTSD-specific signatures, albeit underpowered, accurately stratify veterans with PTSD relative to combat-exposed controls. Overall, in vitro PTSD and glucocorticoid response signatures in blood and brain cells represent exciting new platforms with which to test the genetic and epigenetic mechanisms underlying PTSD, identify biomarkers of PTSD risk and onset, and conduct drug-screening to identify novel therapeutics to prevent or ameliorate clinical phenotypes.
Does Microfinance Program Innovation reduce income inequality? A cross-country analysis
Authors: Miled Kamel Bel Hadj , Younsi Moheddine 
Published: February 2021

Abstract
This study examines the relationship between microfinance and income inequality at the macro level using cross-country and panel data. We show that a country with higher MFIs’ gross loan portfolio per capita tends to have lower income inequality, which confirms the beneficial role of microfinance in reducing income inequality at the macro level. Our results suggest that microfinance loans can lead to improve the relative income position of the poor in developing countries, albeit slowly. In the light of the foregoing outcomes, some important recommendations are suggested to the policymakers in order to reducing income inequality. Microfinance becomes an even more popular tool for fighting poverty; reducing income inequality; institutions innovate in their products and programs at a rapid pace
Phase II Trial of Veliparib and Temozolomide in Metastatic Breast Cancer Patients With and Without BRCA1/2mutations
Authors: Xu Jing , Keenan Tanya E , Overmoyer Beth , Tung Nadine Muskatel , Gelman Rebecca , Habin Karleen , Garber Judy , Ellisen Leif W , Winer Eric P , Goss Paul E , Yeap Beow Y , Chabner Bruce , Isakoff Steven J 
Published: February 2021

Abstract
Purpose: We evaluated the efficacy and safety of poly-(adenosine diphosphate-ribose) polymerase (PARP) 1 and 2 inhibitor veliparib and temozolomide in metastatic breast cancer patients with and without germline BRCA1/2 mutations.Methods: In this single-arm phase II trial, patients with metastatic breast cancer received veliparib 30 to 40 mg twice daily on days 1 to 7 with concurrent temozolomide 150 mg/m2 on days 1 to 5 of a 28-day cycle. The primary cohort was unselected for BRCA mutation status, and an expansion cohort enrolled only BRCA1/2 carriers. The primary endpoint was objective response rate (ORR) in each cohort. Secondary endpoints included progression free survival (PFS), clinical benefit rate (CBR), and evaluation of safety and tolerability.Results: In the primary cohort of 41 unselected patients, which included 9 BRCA mutation carriers, the ORR was 10% and clinical benefit rate at 4 months (CBR) was 27%. In the expansion cohort of 21 BRCA1/2 carriers, the ORR was 14% and CBR was 43%. Among all 30 BRCA1/2 carriers, the ORR was 23% versus 0% among non-carriers. In the subset of BRCA1/2 carriers, the ORR was 32% among platinum-naïve patients versus 9% among platinum-exposed patients. The median PFS was 3.3 months among BRCA1/2 carriers compared to 1.8 months among non-carriers (HR: 0.48, p = 0.006). A longer median PFS of 6.2 months was observed among BRCA1/2 carriers who had no prior platinum therapy. The most common grade 3 and 4 toxicities were thrombocytopenia (32%) and neutropenia (21%) that generally improved with dose modifications.Conclusion: Veliparib and temozolomide demonstrated clinical activity in platinum-naïve BRCA-associated metastatic breast cancer with manageable toxicity at doses of veliparib well below the single agent active dose. Although the study did not meet its primary endpoint in unselected nor BRCA-associated breast cancer, this regimen was further evaluated in the BROCADE 2 study. Trial registration: NCT01009788 (ClinicalTrials.gov), November 9, 2009
Incidence and Associated Factors for Neuraxial Anaesthesia-Related Hypotension in COVID-19 Parturients Undergoing Caesarean Delivery: A Multicenter Case-Control Study
Authors: Zhang Yuan , Chen Rong , Cao Chen , Gong Yuan , Zhou Qin , Cheng Hui-hui , Wei Min , Xia Zhong-yuan , Chen Xiang-dong , Meng Qing-tao 
Published: February 2021

Abstract
Background: COVID-19 continues to spread globally and results in additional challenges for perioperative management in parturients. The purpose of this study was to determine the incidence and identify associated factors for neuraxial anaesthesia-related hypotension in COVDI-19 parturients during caesarean delivery.Methods: We performed a multicenter case-control study at 3 medical institutions in Hubei province, China form 1th January to 30th May 2020. All ASA Physical Status II full termed pregnant women who received caesarean delivery under neuraxial anaesthesia were eligible for inclusion. The univariate analysis and binary logistic regression analysis were used to identified the independent predictors of neuraxial anaesthesia-related hypotension.Results: Present study included 102 COVID-19 parturients. The incidence of neuraxial anaesthesia-related hypotension was 58%. Maternal abnormal lymphocyte count (OR = 3.41, p = 0.03), full stomach (OR = 3.22, p = 0.04), baseline heart rate (OR = 1.04, p = 0.03), experience of anaesthetist (OR = 0.86, p = 0.02) and surgeon (OR = 0.76, p = 0.03), and combined spinal-epidural anaesthesia technique (OR = 3.27, p = 0.02) were associated with neuraxial anaesthesia-related hypotension. The area under the receiver operating characteristic curve achieved 0.83 which was significantly higher than 0.5 (p < 0.001). And the sensitivity, specificity and percentage correct were 75%, 79% and 75%, respectively. The Hosmer-Lemeshow test showed a good calibration of the model (H = 2.01, DF = 8, p = 0.98).Conclusions: Maternal abnormal lymphocyte count, full stomach, baseline heart rate, experience of anaesthetist and surgeon, and combined spinal-epidural anaesthesia technique were identified as the independent predictors of neuraxial anaesthesia-related hypotension.
Eye-movement replay supports episodic remembering
Authors: Johansson Roger , Nyström Marcus , Dewhurst Richard , Johansson Mikael 
Published: February 2021

Abstract
When we bring to mind something we have seen before, our eyes spontaneously reproduce a pattern strikingly similar to that made during the original encounter. Eye-movements can then serve the opposite purpose to acquiring new visual information; they can serve as self-generated cues, pointing to memories already stored. By isolating separable properties within the closely bound chain of where and when we look, we demonstrate that specific components of dynamically reinstated eye-movement sequences, facilitate different aspects of episodic remembering. We also show that the fidelity with which a series of connected eye-movements from initial encoding is reproduced during subsequent retrieval, predicts the quality of the recalled memory. Our findings indicate that eye movements are “replayed” to assemble visuospatial relations as we remember. Distinct dimensions of these scanpaths differentially contribute depending on the goal-relevant memory.
Measurements of the Lamb-Mössbauer factor at simultaneous high-pressure-temperature conditions and estimates of the equilibrium isotopic fractionation of iron
Authors: Zhang Dongzhou , Jackson Jennifer M. , Sturhahn Wolfgang , Zhao Jiyong , Alp E. Ercan , Hu Michael Y. 
Published: February 2021

Abstract
Isotopic fractionation has been linked to the lattice vibrations of materials through their phonon spectra. The Lamb-Mössbauer factor (fLM) has the potential to provide information about the lattice vibrations in materials. We constrain the temperature evolution of the fLM of γ- and ε-Fe at in situ high-P-T conditions between 1650 K and the melting point. We find that the vibrations of γ- and ε-Fe can be described using a quasiharmonic model with a pressure- and temperature-dependent Debye temperature computed from the measured fLM. From the Debye temperature, we derive the equilibrium isotopic fractionation β-factor of iron. Our results show that the quasiharmonic behavior of metallic iron would lower the value of lnβFe57/54 by 0.1‰ at 1600–2800 K and 50 GPa when compared to the extrapolation of room temperature nuclear resonant inelastic X-ray scattering data. Our study suggests that anharmonicity may be more prevalent in Fe metal than in lower mantle minerals at 2800 K and 50 GPa, a relevant condition for the core formation, and the silicate mantle may be isotopically heavy in iron.