bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional distress in COVID-19 patients in Maldives
Authors: Dey Rajib Kumar , Mansoor Shanooha , Hilmy Abdullah Isneen , Moosa Sheena , Rahman Shiraany Abdul , Latheef Raishan , Rasheed Nihla , Hassan Fathimath Guraishaa , Zaadhee Ali , Ibrahim Afa , Usman Sofoora Kawsar 
Published: November 2021

Abstract
Background and objectives: Researchers are exploring the epidemiology, clinical characteristics, treatment, vaccination and the challenges faced by healthcare authorities. However less focus is being paid towards the impact of COVID-19 on mental health of the patients. This study is a cross-sectional study, measuring the prevalence of emotional distress among patients with COVID-19 in the Maldivian population.Methods: This study was conducted in Maldivian nations above 18 of age with COVID-19 who were admitted in isolation facilities. Patients who were on treatment for any other chronic medical conditions, severe and critical COVID-19 disease were excluded. This study was conducted over a period of 2months by administering a local translated version of DASS21 questionnaire.Results: The total of 195 patients were included in this study. The mean age of the patients was 40 (CI at 95% 38 - 42) years. The respondents were 48.7% men and 51.3% women. Overall, 9% of patients with COVID-19 had depression while 23% of patients had anxiety and 12% of the patients had stress. There was a statistically significant relationship between gender and depression, anxiety and stress (p<0.01). Symptomatic cases had a significantly higher level of stress than asymptomatic patients (p<0.05), but no significant association was observed with symptomatic status and anxiety or depression.Interpretations & conclusion: The management of patients with COVID-19 should be multi-disciplinary with special focus on the mental wellbeing of our patients. We should aim to establish proper communication with the patients in order to identify emotional distress and provide appropriate mental health care.
Increment of Fault Current due to integration of Distributed Generation and its impact on Distribution Network Protection
Authors: Mekonnen Haymanot Takele 
Published: November 2021

Abstract
BackgroundOne of the new technologies in generating power near the distribution system is called distributed generation which has supportive and destructive characteristics to the power system protection. One of the destructive characteristics of distributed generation is increasing the level of fault current to the protective equipment of the power system. In addition to increment of fault, it also alters the radial nature of the power distribution system and cause the power bidirectional rather than unidirectional. Integration of distributed generation to the distribution network causes increment of fault current effect, reliability drop, and affects security of protection system. The level of failure of protection be contingent on type, size, location and number of distributed generation. This fault current can cause a great damage to the electrical equipment with the miss operations of protective devices. The main aim of this paper is analysis of the fault current level to the protection of distribution network due to the integration of distributed generation which concerns on solar distributed generation, wind distributed generation and combination of solar and wind distributed generations at a time. This paper conducts the analysis for the increment of fault current by the integration of distributed generation and its impact on distribution network protection. ResultsThe analysis and the modeling are conducted on the 15KV distribution network of the radial feeder in Debre Markos town. This paper has covered the ling to ground, line to line and three phase fault analysis and their impact on the protection of distribution system for the wind and solar distributed generation types. After the integration of the distributed generation the fault current is increased by 0.529KA for three phase, 0.74KA for line to ground, 0.467KA for line to line and 0.523KA for line to line to ground. ConclusionsThis paper confirms designing distribution network without forecasting the future demand of electric power users give the protection equipment additional requirement. As the result, the fault current after the integration of distributed generation to the distribution network have great value in terms of power system protection.
Identification of Prognostic Biomarker and Immune Infiltration of CDH23 in Acute Myeloid Leukemia
Authors: Yang Jiao , Lu Fei , Ma Guangxin , Pang Yihua , Zhao Yanan , Sun Tao , Ma Daoxin , Ye Jingjing , Ji Chunyan 
Published: November 2021

Abstract
Background: Cadherin-23 (CDH23), which plays an important role in intercellular adhesion, is involved in the progression of several types of cancer. However, the biological functions and impact of CDH23 expression on the prognosis of patients with acute myeloid leukemia (AML) are yet to be explored. Herein, we aim to characterize the role and molecular functions of CDH23 in AML.Methods: The expression level of CDH23 were assessed in patients with AML by Gene Expression Profiling Interactive Analysis (GEPIA). The prognostic value of CDH23 was analyzed via GEPIA and LinkedOmics. Correlation analysis and biology function analysis were conducted by LinkedOmics and GeneMANIA database. Relationship of CDH23 with immune infiltration level was detected by TIMER. Results: In the present study, aberrant overexpression of CDH23 was first confirmed in patients with AML and contributed to poor prognosis. Notably, we observed a negative correlation between CDH23 mRNA expression and immune cell infiltration by calculating the ESTIMATE score. In addition, functional enrichment analysis confirmed that CDH23 plays a crucial role in tumor immunity. Conclusions: Our findings indicate that upregulation of CDH23 expression corresponded to shortened overall survival of patients with AML. CDH23 may be involved in mediating tumor immunity, and this highlights the potential of CDH23 as a therapeutic target in AML.
Impact of Different Popular Science Models and Other Factors on Satisfaction of Community Health Popular Science Activities in Shanghai Community Residents
Authors: Jiang Ping 
Published: November 2021

Abstract
Objective

To explore and analyze the impact of different popular science models, include traditional and innovative models, and other factors on satisfaction of community health popular science activities in Shanghai community residents.
Method

Four communities were selected in Minhang District, Shanghai, and divided into four groups with simple random sampling method: foreign volunteer medical science talk show group (A), Chinese volunteer medical science talk show group (B), traditional lecture group (C), and control group (D). Using the rules of convenience sampling, 150 residents were randomly selected from each community to participate in 6-month popular science activities, and completed three questionnaires during the 6-month popular science intervention. Data including the sociodemographic data and the satisfaction on community health popular science activities was collected and analyzed.
Results

Compared with those in baseline, the satisfactions of community health popular science activities in three popular science models have all significantly improved with 3 and 6 months popular science intervention (A: χ2 = 47.1, p < 0.001; B: χ2 = 62.0, p < 0.001; C: χ2 = 31.7, p < 0.001) except for in control group (D: χ2 = 0.3, p = 0.9). The factors including gender, education, marital status, popular science model and popular science intervention time all have significant impact on satisfaction. Among these factors, married (Exp (B) = 2.715, 95% CI (1.163-6.336), p = 0.021)), popular science models (foreign volunteer medical science talk show model: Exp (B) = 8.796, 95% CI (5.907-13.100), p < 0.001; Chinese volunteer medical science talk show model: Exp (B) = 5.106, 95% CI (3.564-7.314), p < 0.001 and traditional lecture model: Exp (B) = 13.033, 95% CI (8.374-20.283), p < 0.001), popular science intervention time (3-month: Exp (B) = 3.988, 95% CI (2.827-5.626), p < 0.001; 6-month: Exp (B) = 4.132, 95% CI (2.924-5.840), p < 0.001) have positive impact on satisfaction. While female (Exp (B) = 0.598, 95% CI (0.440-0.813), p = 0.001), and junior college (Exp (B) = 0.295, 95% CI (0.168-0.519), p < 0.001) have negative impact.
Conclusion

Both the innovative and traditional popular science models have positive effect on the satisfaction on Chinese community health popular science activities in Shanghai community residents. In the future, special consideration should be given to the impact of different popular science models and other factors on the popular science effects including the satisfaction, and more tailor-design health popular science activities will be suitable for community residents.
Reproductive and Physiological Responses and Egg Quality Traits of Isa Brown Chickens fed Diets Supplemented with Ginger or Turmeric Powder
Authors: Kujero G.O. , Njoku C.P , Oke Oyegunle Emmanuel , Adeyemi O.A. , Sogunle O.M. , Sobayo R.O. 
Published: November 2021

Abstract
The increasing demand for healthy and low fat poultry products by consumers has necessitated the use of natural growth promoters to enhance hens’ laying performance. This study investigated the reproductive response and egg quality traits of pullet chickens fed dietary turmeric (Curcuma longa) and ginger (Zingiber officinale) powder. Five hundred and four pullets were assigned basal diet (G 0 T 0 ) or basal diet supplemented with 1.5 (G1.5) and 3% (G3) ginger or 1.5(T1.5) and 3% (T3) turmeric to investigate the reproductive responses and egg quality traits of pullet chickens during a 60 week trial period. Data were collected on egg and laid out in a Completely Randomized Design in a 2 x 3 factorial arrangement. Hen-day and hen-housed egg production, egg mass, feed conversion ratio and age at first lay were significantly (p<0.05) affected by phytobiotic type. The best (p<0.05) hen-day, hen-housed, egg mass, FCR, earliest age at first lay and least weight at first lay were obtained in birds placed on 1.5% ginger ration. Percentage mortality was not significant except at the different inclusion levels and was least among birds fed 1.5% phytobiotic inclusion levels. The highest (p<0.05) value for egg length, egg width, egg shape index, albumen weight and yolk colour were obtained in birds fed 3% turmeric diets. Internal egg qualities were most enhanced by turmeric inclusion while dietary ginger improved the external qualities. The study concluded that dietary ginger and turmeric enhanced reproductive performance and egg quality of egg-type chickens fed over their commercial production lifespan without impairing their overall well-being.
In Silico and In Vitro Investigations On Mutated IFNβ-scFv Against Human Collagen Type II
Authors: Alimohammadi Fatemeh , Hojati Zohreh , Ganjalikhani-Hakemi Mazdak 
Published: November 2021

Abstract
Current medications for rheumatoid arthritis (RA), a common synovial autoimmune disease, are associated with adverse effects. Interestingly, interferon beta (IFNβ), effective in multiple sclerosis (MS) treatment, also can help decreasing articular destruction in RA. Here, a novel fusion protein was introduced containing human mutated IFNβ (with mutations in 27th and 101th residues; IFNβ27+101) fused to a single chain fragment variable (scFv) antibody against human collagen type II for decreasing IFNβ27+101 off-targets (according to drug targeting benefits) in future in vivo and clinical experiments. After designing, bioinformatic analyses and the recombinant vector transfection into HEK293 cells, the mutated IFNβ-scFv protein confirmation and function were assessed by SDS-PAGE, western blotting, ELISA, and real-time PCR. The fusion protein secondary and tertiary structures had proper folding. Also, the recombinant mRNA secondary structure considered stable. 2.35 fold difference between the test and negative control groups confirmed the scFv attachment to human collagen type II (p= 0.046). MxA 25.68 fold overexpression in peripheral blood mononuclear cells (PBMCs) treated with the recombinant protein compared with the non-treated sample (p= 0.0001), demonstrated IFNβ27+101 bioactivity as the fusion protein. In vitro and in silico studies verified function of mutated IFNβ-scFv, however in vivo studies are proposed for further validation.
Identificación de prácticas ambientales sostenibles ejercidas por la Administración Distrital de la ciudad de Bogotá en los procesos de contratación adelantados por parte de la Secretaría de Ambiente en la última década
Authors: Cardona Arteaga Beatriz Eugenia 
Published: November 2021

El presente artículo académico tiene como objetivo principal demostrar si existen o no prácticas sostenibles ambientales en la contratación pública que adelanta la ciudad de Bogotá o si están contempladas en un marco legal a través de las actuaciones administrativas que adelante la ciudad, materializadas estas en tres aspectos básicos: uso racional de recursos naturales, la reducción de cargas contaminantes y el desarrollo de iniciativas ambientales enfocadas hacia la sostenibilidad.
Recibido: 3 de marzo de 2021
Revisado: 31 de marzo de 2021
Aceptado: 3 de mayo de 2021
Naturaleza jurídica del contrato de obra pública en relación con las cláusulas excepcionales como mecanismo para lograr el cumplimiento del objeto contractual
Authors: Bastidas Crespo Jorge Luis 
Published: November 2021

Dentro de esas actividades de la contratación pública se encuentra el contrato de obra pública como uno de los instrumentos más completos para poder cumplir los fines del Estado. En la ejecución del contrato de obra pública se presenta una serie de acontecimientos que en ocasiones se desenvuelven en escenarios imprevistos y complejos, que accionan la utilización de las cláusulas excepcionales como herramientas legitimas del Estado para buscar satisfacer el interés general, proteger la moralidad pública, y así alcanzar el cumplimiento del objeto contractual.
Recibido: 5 de marzo de 2021
Revisado: 16 de abril de 2021
Aceptado: 6 de mayo de 2021
Gliadin proteins from wheat flour: the optimal determination conditions by ELISA
Authors: Marjanović-Balaban Željka , Cvjetković Vesna Gojković , Grujić Radoslav 
Published: November 2021

Introduction. The number of people with celiac disease is rapidly increasing. Gluten, is one of the most common food allergens, consists of two fractions: gliadins and glutenins. The research objective was to determine the optimal conditions for estimating gliadins by using enzyme-linked immunosorbent assay (ELISA).
Study objects and methods. The experiment involved wheat flour samples (0.10; 0.20, 0.25, 0.50, and 1.0 g) suspended in different solvents (ethanol, methanol, 1-propanol, and isopropanol) of different concentrations (40, 50, 60, 70, 80, and 90% v/v). The samples were diluted with Tris buffer in ratios of 1:50, 1:100, 1:150, and 1:200. The gliadin test was performed using a Gliadin/Gluten Biotech commercial ELISA kit (Immunolab).
Results and discussion. The optimal conditions for determining gliadin proteins that provided the highest gliadin concentration were: solvent – 70% v/v ethanol, extract:Tris buffer ratio – 1:50, and sample weight – 1.0 g.
Conclusion. The obtained results can be of great importance to determine gliadin/gluten concentrations in food products by rapid analysis methods.
Assessment of radiation dose hazards caused by radon and its progenies in tap water by the human dosimetric model
Authors: Yong Jinlong , Liu Qian , Wu Baoshan , Hu Youhua , Feng Guangwen 
Published: November 2021

Abstract
Radon is readily soluble in water, and radon exposure caused by household water consumption may pose a threat to public health. In this study, the radon concentration in the tap water of residential buildings was measured, and the average value was 543.33 mBq L−1, which was in line with the radon concentration limit recommended by USEPA (11.11 Bq L−1) and EURATOM (100 Bq L−1), and also within the range of the results of radon concentration measurements in tap water in other countries or regions. Through water bath heating at different temperatures, the radon retention curves of multiple groups of samples at different temperatures were fitted and analyzed. The results showed that the radon retention continued to decrease between 25 and 70 °C, remained stable between 70 and 85 °C, and then continued to decline slowly. Combined with the measurement results, the effective doses of α- and β-particles emitted by 222Rn and its progenies to residents respiratory and alimentary tissues and organs were calculated using the computational model provided by ICRP under two typical water scenarios of shower and drinking water, and the results show that radon exposure caused by normal water consumption will not pose a serious threat to public health.
Experimental study of the effect of nanoscale zero-valent iron injected on the permeability of saturated porous media
Authors: Tang Jie , Liu Fei , Zhang Chong , Xue Qiang 
Published: November 2021

Abstract
In a comparison of modified nanoscale zero-valent iron (NZVI), bare NZVI used to remediate deep contaminated groundwater source areas has more advantages. However, the influence of injected bare NZVI deposition on the permeability of aquifer remains unclear, together with which are still the key factors of engineering cost and contamination removal. Hence, this study sought to assess a method of measuring hydraulic conductivity with a constant head device and to examine the permeability loss mechanism of NZVI injected into different saturated porous media, using column tests. The results showed that it was feasible to determine hydraulic conductivity by the constant head device. The permeability loss caused by NZVI injection increased with a decrease in the grain size of the porous media, and was determined by the amount and distribution of NZVI deposition. The NZVI distribution area had a good linear correlation with dispersivity of the porous media. Additionally, although surface clogging occurred in all porous media, the amount of NZVI deposition at the injection point was largest in fine sand, so that its permeability loss was the most; this was more likely to cause hydraulic fracturing and expand the area of the contaminant source zone. These results have implications for NZVI field injection for successful groundwater remediation.
Role of miRNAs in Cancer Diagnostics and Therapy: A Recent Update
Authors: Sayyed Adil A. , Gondaliya Piyush , Bhat Palak , Mali Mukund , Arya Neha , Khairnar Amit , Kalia Kiran 
Published: November 2021

:
The discovery of microRNAs (miRNAs) has been one of the revolutionary developments and has led
to the advent of new diagnostic and therapeutic opportunities for the management of cancer. In this regard, miRNA
dysregulation has been shown to play a critical role in various stages of tumorigenesis, including tumor invasion,
metastasis as well as angiogenesis. Therefore, miRNA profiling can provide accurate fingerprints for
the development of diagnostic and therapeutic platforms. This review discusses the recent discoveries of miRNA-
based tools for early detection of cancer as well as disease monitoring in cancers that are common, like
breast, lung, hepatic, colorectal, oral and brain cancer. Based on the involvement of miRNA in different cancers
as oncogenic miRNA or tumor suppressor miRNA, the treatment with miRNA inhibitors or mimics is recommended.
However, the stability and targeted delivery of miRNA remain the major limitations of miRNA delivery.
In relation to this, several nanoparticle-based delivery systems have been reported which have effectively
delivered the miRNA mimics or inhibitors and showed the potential for transforming these advanced delivery
systems from bench to bedside in the treatment of cancer metastasis and chemoresistance. Based on this, we attempted
to uncover recently reported advanced nanotherapeutic approaches to deliver the miRNAs in the management
of different cancers.
Point of Care Test Technology Suitable for Early Detection and Monitoring of Ischemic Stroke
Authors: Lee Young Mi , Bae Mi Jung , Choi Ye Seul , Lee Eunmi , Cho Junghwan , Kim Myung-Gwan , Le Minh Tan , Nguyen Thi Hong Duc , Han Hyung Soo , Park Nora Jee-Young , Chong Gun Oh 
Published: November 2021

Background:
Stroke is one of the leading causes of death and disability in adulthood
worldwide. A simple and convenient diagnostic method is needed for monitoring high-risk patients
for stroke. Few POCTs are available for stroke diagnosis. Soluble blood P-selectin is known as a
biomarker for platelet aggregation. Increased expression of P-selectin is observed in coronary
artery disease, acute myocardial infarction, stroke and peripheral arterial disease.

Objective:
A simple method that can measure the increased expression of P-selectin in stroke patients
is intended to be used for diagnosis or early detection and hospital monitoring of ischemic
stroke.

Method:
Plasma proteins in blood were separated using a three-layered filter system. Quantum
dot and antibody were conjugated to detect biomarkers present in plasma and then measured with a
fluorescence spectrophotometer.

Results:
The detection limit of soluble P-selectin confirmed by immunoassay was 1 ng/ul. In order
to increase the sensitivity and simplify the reaction, the detection limit was measured to evaluate
the sensitivity of the quantum dot labeled anti P-selectin antibody. As a result, P-selectin of 5 ng/ul
or more showed saturation signal intensity, indicating the upper limit of detection, and 10 pg/ul
was the lower limit of detection.

Conclusion:
In this study, we proposed a three-layer filter membrane system that can separate biomarker-
rich fractions from whole blood, simplifying the analysis process and improving sensitivity
by using quantum dot-labeled antibodies to detect biomarkers. We hope that our system complements
the advantages of POCT and can be applied to real clinical applications.
A Review of Artificial Intelligence in Cerebrovascular Disease Imaging:
Applications and Challenges
Authors: Chen Xi , Lei Yu , Su Jiabin , Yang Heng , Ni Wei , Yu Jinhua , Gu Yuxiang , Mao Ying 
Published: November 2021

Background:
A variety of emerging medical imaging technologies based on artificial intelligence
have been widely applied in many diseases, but they are still limitedly used in the cerebrovascular
field even though the diseases can lead to catastrophic consequences.

Objective:
This work aims to discuss the current challenges and future directions of artificial intelligence
technology in cerebrovascular diseases through reviewing the existing literature related to applications
in terms of computer-aided detection, prediction and treatment of cerebrovascular diseases.

Methods:
Based on artificial intelligence applications in four representative cerebrovascular diseases
including intracranial aneurysm, arteriovenous malformation, arteriosclerosis and moyamoya disease,
this paper systematically reviews studies published between 2006 and 2021 in five databases:
National Center for Biotechnology Information, Elsevier Science Direct, IEEE Xplore Digital Library,
Web of Science and Springer Link. And three refinement steps were further conducted after
identifying relevant literature from these databases.

Results:
For the popular research topic, most of the included publications involved computer-aided
detection and prediction of aneurysms, while studies about arteriovenous malformation, arteriosclerosis
and moyamoya disease showed an upward trend in recent years. Both conventional machine
learning and deep learning algorithms were utilized in these publications, but machine learning
techniques accounted for a larger proportion.

Conclusion:
Algorithms related to artificial intelligence, especially deep learning, are promising
tools for medical imaging analysis and will enhance the performance of computer-aided detection,
prediction and treatment of cerebrovascular diseases.