bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the professional career values and career awareness of athlete- students: the sample of the faculty of sports sciences
Authors: Döşyılmaz Enver , Şirin Tayfun 
Published: October 2021

Background and Study Aim. Athlete-students continue their athletic careers at a professional level during their education, or many try to pursue alternative career paths. While much attention has been given to Athlete-students' academic progress and graduation rates in the literature, little attention has been paid to their attitudes towards career values and career awareness. Therefore, this study aimed to determine the career awareness and career values of athletes-students according to some demographic variables.
Material and Methods. This cross-sectional descriptive-correlational study was performed in the Sports Science Faculty of Kahramanmaras Sutcu Imam University of Turkey which forms the universe of the study. A total of 334 (162 female and 172 male) athletes-students who were undergraduate students in the sports sciences faculty of the university participated in the research. The data collection tool in the study "Professional Career Awareness Scale", and "Career Values Scale" was used. T-test and One-Way ANOVA tests were used to perform the differential analysis and Pearson Correlation analysis was used to determine the correlation between variables.
Results. According to the results of the research, it was found that scores of the professional career values and career values of the athletes-students were at a moderate level. It was observed that the students' career values dimensions perception scores differed according to their perception scores and gender, department, class, age variables; there was no difference between the variable of being a licensed athlete and the dimensions. Differences were observed between career awareness dimensions, professional development disposition, and department and age variables. There was no difference between career awareness dimensions and gender, status of being a licensed athlete, and class variable. In addition, it is seen that there is a low and moderate relationship between professional career awareness and career values sub-dimensions.
Conclusions. According to these results, it can be said that due to the lack of standardized measures of athlete-student career development, career awareness and career values are at a moderate level and their perceptions differ according to their demographic characteristics.
Investigating the Effectiveness of Group Training Based on Reforming Schema on Improving Individual and Social Health of Mothers’ Problems
Authors: Jafari Nodoushan Reza , Anoosheh Vidasadat , Shafiezadeh Bafghi Mahdieh , Barzegari Mohammad Ali , Jafari Ali , Damiri Hojat , Hosseini Hanzaei Azam 
Published: October 2021

Introduction: Due to the important role of the mothers in the families, identifying their early maladaptive schema can help us identify the problems that lead to unhealthy life education and provide the necessary and appropriate training programs to improve them. This study uses group training to reform schema in improving mothers' individual and social mental health who consulted the social damage prevention center. The purpose of the study was to determine the effectiveness of reforming schema on a mothers' problems.
Methods: In this study, the quasi-experimental method was used. The study population was all the mothers who had parenting problems in the last two years and have consulted the social damage prevention center. Nonrandom sampling was used for our statistical census. Therefore, 100 mothers at hand were selected nonrandomly, and the General Health Questionnaire (GHQ) was conducted on them as a pre-test. Then, 24 mothers who obtained the lowest scores were randomly divided into two groups: experimental and control, in each of which there were 12 participants. The experimental group received training in 10 sections for 90 minutes, while the control group did not receive any training. Afterward, a post-test was conducted for each group, and the results of the two groups were compared.
Results: A covariance analysis test was used to test the hyper hypotheses. The results showed a significant difference between the experimental and control groups in the individual's mental health and social mental health variables (p < 0.001). Thus, hypotheses 1 and 2 were approved in our study. In other words, the comparison of the average in two variables after the post-test of experimental and control groups showed that mothers trained according to reforming schem, had better social and mental health. With approximately 90%, it can be said that the training based on reforming schema effectively increases the social and individual health of the mothers challenging with parenting problems.
Factors Impacting Why Women Stay in Marital Life with Substance dependent Husbands: A Grounded Theory Study
Authors: Rostami Farahnaz , Fathi Elham , Hatami Varzaneh Abolfazl , Daneshpour Manijeh 
Published: October 2021

Introduction: Substance abuse is one of the major factors leading to divorce in Iran. Therefore, this study aimed to present a qualitative model of factors affecting women to stay married with substance-dependent husbands.
Methods: The grounded theory in the qualitative paradigm was used. Twenty participants (10 women and 10 experts) were interviewed based on theoretical saturation, purposeful, and snowball sampling, and semi-structured in-depth interviews. The interviews were analyzed using the constant comparative method.
Results: The participants’ mean age for women was (M=35.2, SD=7.40, n=10) and for experts was (M= 37. 3, SD= 7.42, n=10), half of whom were men and half were women for experts. The results indicated that causal conditions consisted of the child as a barrier to leaving the marital relationship; feeling satisfied with the marital relationship; the attitudes, expectations, and feelings of the spouses; promising behaviors of the husband; financial dependency on the husband, and level of substance-related disorder. The intervening condition was the family of origin’s role. The women's survival strategies in marital life include the use of supportive resources, increasing awareness, and the use of constructive behaviors. The contextual conditions were social and legal factors. Consequences of the core category (A journey with fear and hope), were desirable and undesirable emotions and experiences.
Conclusion: The results indicated that spouses of substance-dependent husbands stay in the marriage, not just due to obstacles like familial, social, legal, and financial factors, but also due to resourceful supports, marital satisfaction, and enjoy having a family with husband and children.
Most Frequently Affected Body parts in Road Traffic Accidents Reporting to the Accident and Emergency Department of the Largest Tertiary Care hospital of Karachi in 2019
Authors: Ahmer Zaeema , Siddiqui Aisha 
Published: October 2021

Introduction Injuries sustained during Road Traffic Accidents (RTAs) amounts to a serious public health crisis. The aim of the study was to determine the body parts most likely affected in an RTA in patients brought to Accident and Emergency (A&E) department of Jinnah Postgraduate Medical Centre (JPMC), the largest tertiary care hospital of Karachi.
Method A descriptive cross-sectional study was done in January-March 2019 among 371 respondents aged 15-65 years. Study participants were recruited through non-probability convenience sampling. A structured questionnaire was used to collect data on sociodemographic variables and type, severity and nature of injury. Chi Square test was used to determine the significant difference between using safety precautions with body parts affected. All analysis was performed on SPSS version 20.
Results Out of 371 study participants, 64.4% (n=239) were between 15-35 years with 91.9% (n=338) males. In 77.1% (n=286) cases, emergency medical services responded in less than one hour and first aid was provided by doctor to 95.7% (n=355) at hospital. In 82.5% (n=306) cases, private vehicles were involved, with 46.1% (n=171) motorcycles. In 79.8% (n=296) cases, bone injury was prevalent, with 57.1% (n=212) leg injuries, which was the most frequently affected body part. Majority, 56.2% of the study participants who did not wear seat belts had chest area affected (p=0.006).
Conclusion It is concluded that males of 15-35 years who were motorcyclists were more prone to RTAs with lower limbs more frequently being affected. Safety precautions like wearing seatbelts provide protection against RTAs.
Effect of Ambient Temperature on the Spread of COVID-19: A Systematic Review
Authors: Heydari Ahad , Fallah-Aliabadi Saeed , Habibi Peymaneh 
Published: October 2021

Introduction: So far, the so many people has been infected by novel coronavirus (SARS-CoV-2) in the worldwide and almost all the countries have reported infected and death cases. Some studies have shown that coronaviruses are sensitive to air temperature and in warm temperature the rate of spread decreases. This study aimed to review the literature whether or not the temperature can affect the spread rate of COVID-19.
Methods: In this study, three main scientific electronic databases, including Scopus, PubMed, Web of Science and also Scholar Google were searched on April 14, 2020 to find relevant studies on COVID-19 and its spread in different ambient temperature.
Results: Totally 588 articles were found for screening and 27 articles were selected for data extraction. The result of some of these studies showed that weather variations can affect transmission of coronavirus. Low temperature and low humidity may be essential factors for survival of coronaviruses. A temperature of 4°C is ideal for the life of this virus and it may be sensitive to 70°C temperature. The increase in temperature of stainless steel, wood, fabrics, and metal can eliminate and remove coronaviruses according to the findings of some of these reviewed articles.
Conclusion: This review study failed to precisely report the effect of temperature or humidity to stop the virus from spreading and transmitting. It is required to conduct more studies in this regard to introduce the exact pattern of transmission by examining the conditions of virus transmission in different climatic conditions.
Prognostic Value and Underlying Mechanism of Autophagy-related Genes in Bladder Cancer
Authors: Peng Shiyuan , Ma Shanjin , Yang Fa , Xu Chao , Li Hongji , Lu Shiqi , Zhang Jingliang , Jiao Jianhua , Han Donghui , Shi Changhong , Zhang Rui , Yang An-Gang , Zhang Keying , Wen Weihong , Qin Weijun 
Published: October 2021

Abstract
Bladder cancer (BLCA) is the most common malignancy whose early diagnosis can ensure a better prognosis. However, the predictive accuracy of commonly used predictors, including patients’ general condition, histological grade, and pathological stage, is insufficient to identify the patients who need invasive treatment. Autophagy is regarded as a vital factor in maintaining mitochondrial function and energy homeostasis in cancer cells. Whether autophagy-related genes (ARGs) can predict the prognosis of BLCA patients deserves to be investigated. Based on BLCA data retrieved from the Cancer Genome Atlas (TCGA) and ARGs list obtained from the Human Autophagy Database (HADb) website, we identified prognosis-related differentially expressed ARGs (PDEARGs) through Wilcox text and constructed a PDEARGs-based prognostic model through multivariate Cox regression analysis. The predictive accuracy, independent forecasting capability, and the correlation between present model and clinical variables or tumor microenvironment (TME) were evaluated through R software. Enrichment analysis of PDEARGs was performed to explore the underlying mechanism, and a systematic prognostic signature with nomogram was constructed by integrating clinical variables and the aforementioned PDEARGs-based model. We found that the risk score generated by PDEARGs-based model could effectively reflect deteriorated clinical variables and tumor-promoting microenvironment. Additionally, several immune-related gene ontology (GO) terms were significantly enriched by PDEARGs, which might provide insights for present model and propose potential therapeutic targets for BLCA patients. Finally, a systematic prognostic signature with promoted clinical utility and predictive accuracy was constructed to assist clinician decision. PDEARGs are valuable prognostic predictors and potential therapeutic targets for BLCA patients.
Prognostic Value of Tertiary Lymphoid Structures in Cancer - A Systematic Review and Meta-Analysis
Authors: Cui Xue , Weng Yiming , Feng Jia , Jin Yao , Xu Zexi , Wang Peiwei , Ruan Peng , Luo Ruijun , Luo Pengcheng , Peng Min 
Published: October 2021

Abstract
Background: Some studies have found that immune cell spatial structures, also known as tertiary lymphoid structures (TLSs), may have prognostic value in cancer. However, these studies all had insufficient sample sizes and inconsistent conclusions. To overcome these problems and draw conclusions, a systematic review and meta-analysis was conducted to determine the prognostic impact of TLSs in cancer.Methods: PubMed, Web of Science, and Embase databases were searched to identify eligible articles published before April 2021. Two authors assessed each record, ensuring that the PICOS framework was met, and risk of bias on the study level was assessed using the Cochrane Bias Risk Assessment Tool. We then performed a meta-analysis using Review Manager 5.3 program to obtain a comprehensive estimate of the prognostic role of TLSs. Results: In total, 28 studies were included in our analysis. We found that in comparison to cancer patients with low TLSs levels, those with high TLSs levels had a better overall survival (OS, hazard ratio [HR]: 0.48, 95% confidence interval [CI]: 0.40-0.57, p<0.00001) and disease-free survival (DFS, HR: 0.52, 95% CI: 0.42-0.63, p<0.00001). Surprisingly, after receiving immune checkpoint inhibitors (ICIs) therapy, cancer patients with high TLSs levels also had a better OS (HR, 0.28; 95% CI, 0.16-0.48; p<0.00001). Furthermore, our subgroup analysis showed that the density of DC-Lamp+ dendritic cells (DCs) and CD20+ B cells in TLSs represented better clinical outcomes.Conclusion: To the best of our knowledge, this study is the first meta-analysis to show the significant prognostic value of TLSs in cancer, to date. Moreover, TLSs are expected to be a potential marker for predicting anti-tumor immune response, which may help clinicians to select patients with cancer who are sensitive to immunotherapy. In addition to their concentration, TLSs components also had strong prognostic value. In particular, the study may provide a novel therapeutic target for patients with cancer and provide a new theoretical basis for future research on tumor immunotherapy.
Evaluation and Experience in the Treatment of Coronal Plane Elbow Fractures via the Anterior Approach
Authors: Jia Qiyu , Li Xiangxiang , Zhan Jing , Chen Dongsheng , Liu Kai , Wang Yingbo , Yusufu Aihemaitijiang , Ma Chuang 
Published: October 2021

Abstract
Background: The existing approaches to treating elbow fractures include anterior, external, internal, and posterior approaches. Of these, the anterior approach is often not chosen by surgeons to avoid damaging important nerves and blood vessels. In fact, the anterior approach has unique advantages. The purpose of this study was to report the outcomes in 38 patients with coronal plane elbow fractures treated through the anterior approach.Methods: We retrospectively analyzed 38 cases of coronal plane elbow fractures treated through an anterior approach at our institution between March 2015 and July 2019. The length of the surgical incision, operation time, intraoperative blood loss, and postoperative complications were recorded. The range of flexion, extension, and rotation of the affected elbow and the healthy elbow were collected at follow-up. Functional outcomes were evaluated using the Mayo Elbow Function Score (MEPS).Results: All 38 patients were followed up. At the final follow-up, solid osseous union was confirmed for all coronal plane elbow fractures. The mean elbow flexion arc was 129.26 ± 6.9 degrees, and the extension arc was 8.87 ± 6.13 degrees. The mean pronation arc was 83.45 ± 2.9 degrees, and the supination arc was 80.05 ± 2.92 degrees. The mean MEPS was 90.0±7.53 points, with 18 excellent cases and 20 good cases. There was no significant difference in elbow extension, flexion, and pronation between 31 cases of single fracture and the healthy elbow (P > 0.05); the arc of supination was slightly worse than that of the healthy elbow (P < 0.05). The VAS pain scores of the patients before the operation, three months after the operation, and during follow-up were compared. The pain of the patients was significantly reduced after treatment (P < 0.05). Two patients experienced transient postoperative median nerve paralysis, from which they recovered within three months. One patient had mild heterotopic ossification and was not treated because it did not affect the function of the elbow joint. All patients returned to work and were satisfied with the treatment.Conclusion: The anterior approach has the benefits of simplicity, safety, minimal invasion, excellent exposure, and satisfactory prognosis for coronal plane elbow fracture.
A unique adipocyte progenitor population promotes age-related adiposity
Authors: Wang Qiong , Wang Guan , Li Gaoyan , Song Anying , Dai Wenting , Shamlin Nicholas , Qin Hanjun , Medrano Leonard , Dow Joan , Li Aimin , Brown Lucy , Armstrong Brian , Fueger Patrick , Campisi Judith , Wu Xiwei , Jiang Lei , Yang Xia 
Published: October 2021

Abstract
The average fat mass in adults increases dramatically with age, and older people often suffer from visceral obesity and related adverse metabolic disorders. Unfortunately, how aging leads to fat accumulation is poorly understood. It is known that fat cell (adipocyte) turnover is very low in young mice, similar to that in young humans. Here, we find that mice mimic age-related fat expansion in humans. In vivo lineage tracing shows that massive adipogenesis (the generation of new adipocytes), especially in the visceral fat, is triggered during aging. Thus, in contrast to most types of adult stem cells that exhibit a reduced ability to proliferate and differentiate, the adipogenic potential of adipocyte progenitor cells (APCs) is unlocked by aging. In vivo transplantation and 3D imaging of transplants show that APCs in aged mice cell-autonomously gain high adipogenic capacity. Single-cell RNA sequencing analyses reveal that aging globally remodels APCs. Herein, we identify a novel committed preadipocyte population that is age-specific (CP-A), existing both in mice and humans, with a global activation of proliferation and adipogenesis pathways. CP-A cells display high proliferation and adipogenesis activity, both in vivo and in vitro. Macrophages may regulate the remodeling of APCs and the generation of CP-A cells during aging. Together, these findings define a new fundamental mechanism involved in fat tissue aging and offer prospects for preventing and treating age-related metabolic disorders.
Trachyspermum Leaves Extract as a Green Inhibitor for Corrosion Inhibition of Mild Steel in 0.1m HCl: Experimental and Computational Study
Authors: Jafari Niloofar , Ahmadi Sayed Ali , Razavi Razieh 
Published: October 2021

Abstract
The present study aims at investigating the impacts of the extract of Trachyspermum leaves on the mild steel corrosion in 0.1M hydrochloric acid (HCl), while highlighting its inhibitory mechanisms. The effects of mild steel corrosion in solutions of HCl were examined using the gravimetric and galvanostatic polarization techniques, along with EIS analyses. According to the results, the maximum inhibitory effectiveness corresponding to the minimum corrosion rate could be observed at the highest desirable level of inhibitor concentration equal to 100 ppm, while the corrosion rate decreases with an increase in the extract concentration. The absorption examinations indicated the best description of the metal surface interaction by Langmuir isotherm, while obtaining the best exposure time for the Trachyspermum leaves extract adsorption into the surface of the metal in different concentration. Based on the results of polarization, the inhibitors can play the role of a mixed inhibitor, also confirmed by the computational data.
HIV-1 Vif up-regulates the expression of Tat via AKT Signaling pathway: Role of deubiquitinase USP17 and NQO1
Authors: Lata Sneh , Sood Vikas , Banerjea Akhil 
Published: October 2021

Abstract
Human Immunodeficiency Virus-1 (HIV-1) has a small RNA genome and depends on host cellular machinery for most of its activities. Host cellular proteins modulate the expression and activity of viral proteins to combat the virus. HIV-1 proteins are known to regulate each other for the benefit of virus by exploiting these modulations. Here, we report that HIV-1 Vif increases the expression of Tat via AKT signaling pathway. We show that HIV-1 Vif activates AKT signaling pathway by inducing phosphorylation of AKT. Mdm2, downstream target of AKT signaling, increases the expression of Tat protein in ubiquitin-independent manner by up-regulating NQO1 as well as in ubiquitin-dependent manner by inducing the expression levels of USP17 which is a deubiquitinase (DUB) and stabilizes Tat protein. Thus, HIV-1 proteins exploit AKT signaling pathway to escape host restriction factors and promote viral replication.
Las TIC en las aulas hospitalarias. Diseño de un repositorio de contenidos web para la Asociación INeDITHOS
Authors: Tena Gil Vanessa , Salinas Ibáñez Jesús María 
Published: October 2021

Este estudio analiza las nuevas tecnologías, TIC (Tecnologías de la Información y la Comunicación), como recurso didáctico en las escuelas hospitalarias. Se parte de una breve introducción sobre el derecho a la educación y su relación con la educación inclusiva, pasando por analizar la labor de la pedagogía hospitalaria y las aulas hospitalarias con los niños y adolescentes que se encuentran hospitalizados durante largos periodos de tiempo por enfermedad. Se profundiza en el uso de las TIC como herramienta de trabajo en las aulas hospitalarias, con sus potencialidades y problemas. Se indaga sobre algunas experiencias llevadas a cabo en España y sus planteamientos concretos para trabajar con las TIC en las aulas hospitalarias, así como la labor que realiza la Asociación INeDITHOS.
Esta fundamentación teórica permite esbozar una investigación cualitativa a través de un estudio de caso, que se encargará de evaluar un proyecto llevado a cabo con la Asociación INeDITHOS. Un repositorio de contenidos creado con la plataforma Symbaloo para el uso de los voluntarios de la asociación. Diferentes profesionales de la educación evalúan la plataforma a través de un cuestionario abierto que completará dicha investigación obteniendo una serie de resultados. Finalmente, se alcanzan los objetivos iniciales.