bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of picking calcified plaque in the common femoral artery with a long needle: the “calc-pick technique”
Authors: Iwasaki Yoshihiro , Hirano Shojiro , Funatsu Atsushi , Kobayashi Tomoko , Ikeda Takanori , Nakamura Shigeru 
Published: October 2021

AbstractAn 88-year-old man had intermittent claudication of his right leg. Angiography revealed severely calcified plaque in the common femoral artery. Endovascular treatment was performed by contralateral approach. We attempted to penetrate the center of the calcified plaque and perform balloon dilatation. However, a 0.014-inch stiff guidewire could not enter the center of the lesion. Thus, we used an inner cylinder of 15-cm 20G long needle directly through the retrograde femoral sheath and successfully introduced the guidewire into the calcified plaque. Crosser and balloon dilatation resulted in 50 % stenosis. To cross the center of calcified plaque, it is important to obtain sufficient lumen gain at the non-stenting zone.
Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients With Partial Lipodystrophy
Authors: Meral Rasimcan , Malandrino Noemi , Walter Mary , Neidert Adam H , Muniyappa Ranganath , Oral Elif Arioglu , Brown Rebecca J 
Published: October 2021

AbstractContextLeptin replacement with metreleptin improves glycemia and hypertriglyceridemia in severely hypoleptinemic patients with generalized lipodystrophy (GLD), but its effects are variable in partially leptin-deficient patients with partial lipodystrophy (PLD).ObjectiveCompare 3 leptin assays (Study I); identify diagnostic performance of leptin assays to detect responders to metreleptin for each assay (Study II).DesignStudy I: cross-sectional analysis of average bias between leptin assays. Study II: retrospective analysis of diagnostic accuracy of potential leptin cut points to detect clinical responders to metreleptin.SettingNational Institutes of Health; University of Michigan.Participants and InterventionsStudy I: Metreleptin-naïve patients with lipodystrophy (GLD, n = 33, PLD, n = 67) and healthy volunteers (n = 239). Study II: GLD (n = 66) and PLD (n = 84) patients treated with metreleptin for 12 months.Outcome MeasuresLeptin concentrations by Millipore radioimmunoassay (RIA), Millipore enzyme-linked immunosorbent assay (MELISA), and R&D Systems enzyme-linked immunosorbent assay (RDELISA). Response to metreleptin therapy was defined as either reduction ≥1.0% in A1c or ≥30% in serum triglycerides.ResultsRDELISA measured 3.0 ± 9.5 ng/mL higher than RIA; MELISA measured 11.0 ± 17.8 and 14.0 ±19.2 less than RIA and RDELISA, respectively. Leptin by RIA, MELISA, and RDELISA modestly predicted metreleptin response in GLD + PLD [receiver operating characteristic (ROC) area under the curve (AUC) 0.74, 0.69, and 0.71, respectively; P &lt; 0.01 for all] with lower predictive power in PLD (ROC AUC 0.63, 0.61 and 0.65, respectively; P &gt; 0.05 for all). The only reproducible cut point identified on sensitivity analyses was RIA leptin 7.2 ng/mL (sensitivity 56%; specificity 78%).ConclusionsThree common leptin assays are not interchangeable, and a reliable cut point to select responders to metreleptin was not identified.
Orthodoxy, illusio, and playing the scientific game: a Bourdieusian analysis of infection control science in the COVID-19 pandemic
Authors: Greenhalgh Trisha , Ozbilgin Mustafa , Contandriopoulos Damien 
Published: October 2021

Background: Scientific and policy bodies’ failure to acknowledge and act on the evidence base for airborne transmission of SARS-CoV-2 in a timely way is both a mystery and a scandal. In this study, we applied theories from Bourdieu to address the question, “How was a partial and partisan scientific account of SARS-CoV-2 transmission constructed and maintained, leading to widespread imposition of infection control policies which de-emphasised airborne transmission?”. Methods: From one international case study (the World Health Organisation) and three national ones (UK, Canada and Japan), we selected a purposive sample of publicly available texts including scientific evidence summaries, guidelines, policy documents, public announcements, and social media postings. To analyse these, we applied Bourdieusian concepts of field, doxa, scientific capital, illusio, and game-playing. We explored in particular the links between scientific capital, vested interests, and policy influence. Results: Three fields—political, state (policy and regulatory), and scientific—were particularly relevant to our analysis. Political and policy actors at international, national, and regional level aligned—predominantly though not invariably—with medical scientific orthodoxy which promoted the droplet theory of transmission and considered aerosol transmission unproven or of doubtful relevance. This dominant scientific sub-field centred around the clinical discipline of infectious disease control, in which leading actors were hospital clinicians aligned with the evidence-based medicine movement. Aerosol scientists—typically, chemists, and engineers—representing the heterodoxy were systematically excluded from key decision-making networks and committees. Dominant discourses defined these scientists’ ideas and methodologies as weak, their empirical findings as untrustworthy or insignificant, and their contributions to debate as unhelpful. Conclusion: The hegemonic grip of medical infection control discourse remains strong. Exit from the pandemic depends on science and policy finding a way to renegotiate what Bourdieu called the ‘rules of the scientific game’—what counts as evidence, quality, and rigour.
Impact and paybacks of biomedical research findings in Malaysia 2005–2015
Authors: Lai Pei Kuan , Nalliah S. , Teng C.L. , Chen N.L.P. 
Published: October 2021

Background:Impact in research encompasses health, economic, and cultural benefits beyond adding to the knowledge base. Funders are under immense pressure to be accountable for the paybacks from funded research.
Aims and objectives:The aim of this study was to look into the impact of funded biomedical research between the years 2005 and 2015 in Malaysia from the aspects of knowledge production, research targeting and capacity building, as well as health system policy and decision making.
Methods:This study employed a convergent parallel mixed-methods research design. Biomedical projects related to breast cancer, coronary heart disease, and dengue, funded by the Ministry of Health (MOH), Ministry of Higher Education (MOHE), and Ministry of Science, Technology, and Innovation (MOSTI) between the years 2005 and 2015, were included.
Findings:From the questionnaire responses (n=58), on average each funded project managed to produce two outputs and one higher degree student. More than half (61.4%) of the funded projects led to subsequent future research. However, low citations in systematic reviews (10.3%), health policies (6.9%), and clinical practice guidelines (5.2%) were reported. In-depth interviews with the key opinion leaders also saw that most of the local research findings were found to be irrelevant to be adopted into policies by the policymakers.
Discussion and conclusions:Paybacks on knowledge production as well as research targeting and capacity building had been achieved, but impact on health system policy and decision making had not been well attained, due to the lack of relevant research findings needed by the policymakers.
Concept and application of a linearized ring multipass optics configuration
Authors: Waßmuth Björn , Fuchs Guido W. , Zimmermann Henrik , Giesen Thomas F. 
Published: October 2021

A multipass optics (MPO) system is used to increase the optical path length in a limited volume. Well-known concepts such as the White-type cell and the Herriott-type cell are used in many applications. The optical path in these cells leaves a large portion of the cell volume unused. In contrast, MPO systems with astigmatic mirrors have significantly more beam passes per volume, but because of their reduced symmetry along the beam axis they are much more sensitive to misalignment. Our goal is to develop MPO systems that have both: the high beam densities of astigmatic MPO systems and the optical robustness of Herriott-type optics. We show that linearized optical ring resonators, which can be constructed by means of simple

2

×

2

optical ABCD-matrices, lead to suitable solutions. The concept is demonstrated using a MPO system with a base length of 150 mm and a total beam path length of 19.2 m, optimized for laser beams of 10 µm wavelength. The volume of the cell is

295

c
m

3

with a beam density that is four times higher compared to a standard Herriott-type cell.
Crafting Anatomies: Archives, Dialogues, Fabrications, Katherine Townsend, Rhian Solomon and Amanda Briggs-Goode (eds) (2020)
Authors: Slater Alison 
Published: October 2021

Review of: Crafting Anatomies: Archives, Dialogues, Fabrications, Katherine Townsend, Rhian Solomon and Amanda Briggs-Goode (eds) (2020)
London: Bloomsbury, 344 pp.,
ISBN 978-1-35007-548-1, ePDF, £61.20
The frequency and structure of metabolic disorders in obese women in combination with polycystic ovary syndrome
Authors: Bolotova E. V. , Dudnikova A. V. , Krutova V. A. , Prosolupova N. S. 
Published: October 2021

Background: Obesity is considered a global epidemic and is one of the most significant medical and social problems. Research in recent years shows that in 25-45% of cases of obesity, polycystic ovary syndrome (PCOS) is detected. The influence of obesity on the pathogenesis of metabolic disorders in this category of patients remains controversialAims: to determine the frequency and structure of metabolic disorders in obese women in combination with polycystic ovary syndrome (PCOS).Materials and methods: A single-center cross-sectional sample survey of women of reproductive age was conducted. The study included clinical anthropometry with measurement of body weight, height, waist circumference (OT) and hip circumference (OB), followed by calculation of body mass index (BMI) and OT/OB ratio, and measurement of blood pressure (BP). A biochemical blood test was performed, the hormonal status was examined, and an ultrasound examination of the pelvic organs was performed.Results: A survey of 136 women of reproductive age was conducted. Group 1 included obese women without PCOS (59 patients), group 2 included obese women in combination with PCOS (45 patients), and the control group included 38 healthy women. Group 1 included obese women without PCOS (59 patients), and group 2 included obese women with PCOS (45 patients), in the control group — 38 healthy women. Among group 2 patients, dyslipidemia, visceral obesity, arterial hypertension, insulin resistance, hyperinsulinemia, and hyperuricemia were significantly more common (p<0,05). Correlations between BMI and triglycerides, testosterone and total cholesterol were found (p<0,05). Obese and PCOS patients had significantly higher levels of C-reactive protein(CRP), fibrinogen, anti-Müllerian hormone (AMH), and hepatic transaminases (p<0,05). Vitamin D deficiency was detected in 13,2% of patients, and insufficiency — in 22,7% of patients. There is a statistically significant correlation between the level of 25 (OH)D and indicators of BMI, follicle-stimulating hormone, luteinizing hormone (p<0,05), the level of AMH (p=0,008).Conclusions: A high frequency of metabolic disorders in obese women in combination with PCOS has been identified, which necessitates early screening, diagnosis and treatment of these disorders to strengthen reproductive health and prevent chronic non-communicable diseases.
LESZEK KOCZANOWICZ, ANXIETY AND LUCIDITY: REFLECTIONS ON CULTURE IN TIMES OF UNREST
Authors: LEJZEROWICZ MAGDA 
Published: October 2021

In the book entitled Anxiety and Lucidity. Reflections on Culture in Times of Unrest Leszek Koczanowicz reflects upon the phenomena of fear and anxiety in essential areas of life, both for the individual as well as the community. He adopts an interdisciplinary perspective so characteristic of an insightful researcher of culture. Fear and anxiety, as he argues, are intrinsic to modernity - the inability to get rid of them is characteristic of modern man. Koczanowicz puts his thoughts on paper in a demanding fashion, which does not, however, obscure the pleasure of reading these well-written and intelligent texts. The author's knowledge is vast, which transpires in the reviewed publication.
LVRT enhancement of DFIG-driven wind system using feed-forward neuro-sliding mode control
Authors: Hiremath Ravikiran , Moger Tukaram 
Published: October 2021

Abstract
Power generation losses arise in doubly fed induction generator (DFIG) system due to grid faults. The system’s protection should ensure that the wind turbine (WT) generator meets the grid requirements through a low voltage ride through (LVRT) technique. This article proposes the feed-forward neuro-second order sliding mode (FFN-SOSM) control for the LVRT enhancement under voltage sag. This controller operates with the levenberg marquardt (LM)-super twisting (ST) algorithm for the uncertainties of the DFIG system. The LM-ST algorithm-based proposed controller is subjected to stability analysis. The advantages of the proposed controller are that it reduces the system parameter’s peak values and harmonic distortion of the system during grid disturbance. The performance of the proposed controller is compared with existing controllers in the literature with the help of MATLAB/SIMULINK. The hardware-in-loop (HIL) validates these simulation results performed on the OPAL-RT setup. Based on the studies, it is found that the proposed controller enhances the LVRT performance of the WT-DFIG system under transient conditions.
Optimal placement of wide area monitoring system components in active distribution networks
Authors: Chauhan Surinder , Dahiya Ratna 
Published: October 2021

Abstract
The optimal placement of micro-Phasor Measurement Units (µPMUs) reduce the cost of wide area monitoring system (WAMS) in active distribution networks (ADNs); therefore, it is becoming a popular research topic. However, µPMUs alone cannot minimize the WAMS cost. An appropriate location of Phasor Data Concentrator (PDC) and a fiber optic communication link (CL) that transfers data from µPMUs to PDCs also need to be optimized. Hence this paper proposes a hybrid algorithm that determines the optimal cost-effective solution of the placement problem of µPMUs, PDC, and CL. The proposed algorithm uses the graph theory and binary integer linear programming (BILP) with the constraints of distribution generation (DG) presence, regular network reconfiguration, and maximizing system redundancy. The proposed algorithm is tested on IEEE 69 bus, IEEE 123 bus, and 345 bus active distribution system. The results obtained show the reduction in cost mainly through the CL and optimal placement of µPMUs in decentralized WAMS.
Old Testament Imaginaries of the Nation in German, Dutch, and Anglo-American Protestant Political Thought
Authors: Johnson Sophia , van der Tol Mariëtta 
Published: October 2021

Abstract
This issue draws attention to the importance of Old Testament scholarship to conceptions of nationhood in Protestant political thought. Inclusive of biblical studies, history, theology, and political thought, this issue discusses hermeneutical as well as political tensions that are inherent to the reception of the Old Testament within political theology. These tensions primarily concerned the role of covenant, reason and the natural order, spilling into what would be recognized today as supersessionism, antisemitism and in some cases, even racism. Within that, it remains important to distinguish political contexts as the historical role of Protestant traditions and their current significance to right-wing uses of biblical imaginaries of the nation differs between Germany, the Netherlands as well as Anglo-American countries.
The pandemic silver lining: preparing osteopathic learners to address healthcare needs using telehealth
Authors: Taylor Jennifer , Wright Amanda , Summers Michael 
Published: October 2021

Abstract

Context
During the COVID-19 pandemic, many clinicians quickly adapted their way of practicing patient care by offering telehealth and virtual office visits while simultaneously having to minimize direct patient care. The shift in direct clinical learning opportunities provided to third- and fourth-year medical students required a shift in the educational curriculum to develop learner skills around the appropriate use of telehealth in patient care.

Objectives
The aim of this project was to provide exposure to students so they could learn the telemedicine equipment and best practices, and how to identify infectious diseases to improve access to care and meet the needs of the patient.

Methods
In July and August of 2020, the Indiana Area Health Education Centers Program partnered with Marian University College of Osteopathic Medicine (MUCOM) to support a 1 day telehealth simulation (online curriculum, group lecture, and two standardized patient encounters) into their clerkship curriculum. We utilized a retrospective pretest-posttest to assess changes in learner knowledge around telehealth after the program. At the conclusion of the telehealth training program, students were asked to complete a retrospective pretest-posttest assessing their level of preparedness to utilize telehealth equipment, their preparedness to demonstrate “telehealth best practices” in a manner consistent with protecting patient (and data) privacy, their confidence to utilize telehealth for identification of infectious diseases, and their confidence to utilize telehealth to identify proper treatment plans.

Results
A total of 96 learners completed the program in 2020. Posttest results demonstrate a statistically significant (p<0.05) improvement for learners’ self-reported level of preparedness to utilize telehealth equipment, their preparedness to demonstrate “telehealth best practices” in a manner consistent with protecting patient (and data) privacy, their confidence to utilize telehealth for identification of infectious diseases, and their confidence to utilize telehealth to identify proper treatment plans.

Conclusions
Our telehealth curriculum involving a video, interactive learning session, and two standardized patient experiences provided osteopathic medical learners with realistic simulated case scenarios to work through in effort to improve their knowledge and self-efficacy around the utilization of telehealth in practice.
Microstructure, mechanical and corrosion properties of nickel superalloy weld metal
Authors: Kısasöz Alptekin , Tümer Mustafa , Karaaslan Ahmet 
Published: October 2021

Abstract
Inconel 625 alloy is used in aggressive environments at high temperatures such as in petro-chemical applications, in the aeronautical and nuclear energy industries because of its propitious mechanical properties and corrosion resistance. In this study, Inconel 625 samples were joined with ERNiCrMo-3 filler metal using the MIG (metal inert gas) method. Also, the relationship between the microstructure and corrosion properties of the Inconel 625 weld were investigated. The microstructure properties of the weld metal were determined by a light metal microscope (LMM), a scanning electron microscope (SEM) and by energy dispersive spectroscopy (EDS) analysis. Moreover, the corrosion properties of the weld metal and the base material were examined by potentiodynamic polarization tests. The corrosion behavior and parameters of the electrochemical potentiodynamic polarization were determined depending on microstructure properties. Inconel 625 was joined successfully via multipass welding. Moreover, excessive heat input ensured the formation of intermetallic phases. Mechanical and corrosion properties of the weld metal were affected negatively due to the formation of intermetallics.
Der Erstgeborene Eingeborene oder warum man das Gerade nicht krumm machen soll. Ein neues unbekanntes griechisches Fragment aus dem Kommentar Cyrills von Alexandrien zum Hebräerbrief
Authors: Zawadzki Konrad F. 
Published: October 2021

Abstract
The present article offers the first edition of a hitherto unpublished Greek fragment from Cyril of Alexandria’s lost commentary on Hebrews. Moreover, the article provides a German translation of it and a discussion about its authenticity. A detailed theological analysis of the fragment that contains Cyril’s explanation of the Greek term ὁ πρωτότοκος (Hebr 1,6) concludes the article.
Justin’s Dialogue and the Search for Contemporary Discourse Between Christians and Jews: A Closer Look at Dialogue, Chapter 47
Authors: Georges Tobias 
Published: October 2021

Abstract
There has been a long-lasting scholarly debate on whether Justin’s Dialogue with Trypho reflects an authentic “Christian-Jewish dialogue.” Without claiming to provide an answer, this paper will focus on Dialogue, chapter 47 in order to point to a contemporary discourse between Christians and Jews that might form the background of Justin’s writing: In chapter 47, Trypho and Justin discuss whether there will be eternal salvation for Jews who believe in Jesus as the Messiah and continue to observe the law. Against other Christian opinions, Justin argues they will be saved provided they do not force their fellow Christians to observe the law to the same degree that they themselves do. While this is good evidence of an inner-Christian discourse on the salvation of Christ-believers who continue adhering to the law, the subsequent lines in chapter 47 suggest that those Jews who do not believe in Jesus Christ are part of the broader Christian-Jewish discourse on eternal salvation. This is because for Justin the crux in all attempts to make Christians observe the law (even the attempts of assumed Christ-believers) is they tend to replace faith in Christ with observance of law to the exclusion of the former. It is precisely the question of eternal salvation that motivates Justin and Trypho to start their discussion in the Dialogue (8,2–4).
Vergleich von Methoden zur Auswahl Digitaler Technologien für KMU
Authors: Solis Lesly Sánchez , Axmann Bernhard , Schuldt Tino 
Published: October 2021

Abstract
Kleine und mittlere Unternehmen (KMU) sind ein wichtiger Baustein für das Wirtschaftswachstum. KMU müssen digitale Technologien einführen, um wettbewerbsfähig zu bleiben. Aber wie wählt man die digitale Technologie aus, die am besten für das eigene Unternehmen geeignet ist? Dieser Beitrag untersucht zehn verfügbare methodische Vorgehensweisen und bewertet diese mit einem Paarweisen Vergleich nach Eignung und Effizienz für KMU. Dabei sind zwei methodische Vorgehensweisen für KMU gut anwendbar. Es muss aber die Effizienz dieser Methoden-Vorgehensweisen verbessert werden, um die Bedürfnisse und Eigenschaften von KMU noch besser zu berücksichtigen.