bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance and characteristics of the Newborn Hearing Screening Program in Campania region (Italy) between 2013 and 2019
Authors: Malesci Rita , Del Vecchio Valeria , Bruzzese Dario , Burattini Ernesto , Auletta Gennaro , Errichiello Monica , Fetoni Anna Rita , Franzè Annamaria , Laria Carla , Toscano Fabiana , Caso Antonio , Marciano Elio 
Published: March 2021

Abstract
Purpose
Universal newborn hearing screening (UNHS) in the first month of life is crucial for facilitating both early hearing detection and intervention (EHDI) of significant permanent hearing impairment (PHI). In Campania region, UNHS has been introduced in 2003 by the Regional Council Resolution and started on January 2007. The aim of this paper is to update a previous article describing the performance of the program since its implementation in the period between 2013 and 2019.

Methods
A longitudinal retrospective study was carried at the Regional Reference Center III on 350,178 babies born in the analysis period. The paper reports the main results of overall coverage, referral rate, lost-to-follow-up rate,yield for PHI and shall determine various risk factor associations with hearing impairment

Results
In Campania region, 318,878 newborns were enrolled at I level, with a coverage rate of 91.06%, 301,818 (86.18%) Well Infant Nurseries (WIN) and 17,060 (5.35%) Neonatal Intensive Care Unit (NICU) babies. PHI was identified in 413 children, 288 (69.73%) bilaterally and 125 (30.26%) unilaterally. The overall cumulative incidence rate of PHI was 1.29 per 1000 live-born infants (95% CI 1.17–1.42) with a quite steady tendency during the whole study period.

Conclusions
This study confirms the feasibility and effectiveness of UNHS in Campania region also in a setting with major socioeconomic and health organization restrictions.The program meets quality benchmarks to evaluate the progress of UNHS. Nowadays, it is possible to achieve an early diagnosis of all types of HL avoiding the consequences of hearing deprivation.
Functional tests to guide management in an adult with loss of function of type-1 angiotensin II receptor
Authors: Viering Daan H. H. M. , Bech Anneke P. , de Baaij Jeroen H. F. , Steenbergen Eric J. , Danser A. H. Jan , Wetzels Jack F. M. , Bindels René J. M. , Deinum Jaap 
Published: March 2021

Abstract
Background
Genetic loss of function of AGT (angiotensinogen), REN (renin), ACE (angiotensin-converting enzyme), or AGTR1 (type-1 angiotensin II receptor) leads to renal tubular dysgenesis (RTD). This syndrome is almost invariably lethal. Most surviving patients reach stage 5 chronic kidney disease at a young age.

Methods
Here, we report a 28-year-old male with a homozygous truncating mutation in AGTR1 (p.Arg216*), who survived the perinatal period with a mildly impaired kidney function. In contrast to classic RTD, kidney biopsy showed proximal tubules that were mostly normal. During the subsequent three decades, we observed evidence of both tubular dysfunction (hyperkalemia, metabolic acidosis, salt-wasting and a urinary concentrating defect) and glomerular dysfunction (reduced glomerular filtration rate, currently ~30 mL/min/1.73 m2, accompanied by proteinuria). To investigate the recurrent and severe hyperkalemia, we performed a patient-tailored functional test and showed that high doses of fludrocortisone induced renal potassium excretion by 155%. Furthermore, fludrocortisone lowered renal sodium excretion by 39%, which would have a mitigating effect on salt-wasting. In addition, urinary pH decreased in response to fludrocortisone. Opposite effects on urinary potassium and pH occurred with administration of amiloride, further supporting the notion that a collecting duct is present and able to react to fludrocortisone.

Conclusions
This report provides living proof that even truncating loss-of-function mutations in AGTR1 are compatible with life and relatively good GFR and provides evidence for the prescription of fludrocortisone to treat hyperkalemia and salt-wasting in such patients.
Clay mineral formation in Permian rocks of a geothermal borehole at Northern Upper Rhine Graben, Germany
Authors: Nguyen-Thanh Lan , Mählmann Rafael Ferreiro , Hoang-Minh Thao , Petschick Rainer , Reischmann Thomas , Nesbor Heinz-Dieter , Ruttmann Myriam , Fritsche Johann-Gerhard 
Published: March 2021

AbstractHydrothermally altered rhyolite rocks in the Permian Donnersberg Formation of a geothermal borehole in the Northern Upper Rhine Graben (Germany) were investigated to find out answers for the low hydraulic conductivity of the rocks. The composition of clay minerals and the temperature of smectite–illite transformation were carried out using X-ray diffraction, X-ray fluorescence, transmission electron microscopy, Fourier transform infrared spectroscopy, and polarized-light microscopy analyses. Clay mineral (CM) composition includes illite/muscovite (1Mand 2M1polytypes), illite–smectite interstratifications (IS-ml), smectite, and chlorite; and non-clay minerals such as quartz, feldspars, epidote, calcite, dolomite, and hematite were detected. The 2M1-polytype mica might be the only primary sheet silicates from the parent rocks, while the others occur as authigenic neo-formed CMs under heat flow and geothermal gradient. The development of CMs indicates different mechanisms of illitization and smectitization. Based on the texture, morphology, structure/polytype, and chemistry of rocks and minerals, in particular CMs, the study grouped the CM formation into three transformation processes: smectitization during magma cooling and possible contact metamorphisms with decreasing and low temperature, smectite illitization controlled by burial diagenesis and hydrothermal alteration, and illite smectitization followed exhumation and Cenozoic subsidence with decreasing temperature. The rhyolites were altered to all of the orders IS-R0, IS-R1, and IS-R3 by the dissolution-precipitation and layer-to-layer mechanisms. The first one supported small xenomorphic plates and flakes of 1Md, elongated particles of 1M, and pseudo-hexagonal forms of 2M1. The second one could lead to the platy particles of 1Mdand 2M1polytypes. The dominant temperature range for the transformation in the area has been 140–170 °C– ~ 230 °C.
Verification of Coupled Hydraulic Fracturing Simulators Using Laboratory-Scale Experiments
Authors: Deb Paromita , Salimzadeh Saeed , Vogler Daniel , Düber Stephan , Clauser Christoph , Settgast Randolph R. 
Published: March 2021

AbstractIn this work, we aim to verify the predictions of the numerical simulators, which are used for designing field-scale hydraulic stimulation experiments. Although a strong theoretical understanding of this process has been gained over the past few decades, numerical predictions of fracture propagation in low-permeability rocks still remains a challenge. Against this background, we performed controlled laboratory-scale hydraulic fracturing experiments in granite samples, which not only provides high-quality experimental data but also a well-characterized experimental set-up. Using the experimental pressure responses and the final fracture sizes as benchmark, we compared the numerical predictions of two coupled hydraulic fracturing simulators—CSMP and GEOS. Both the simulators reproduced the experimental pressure behavior by implementing the physics of Linear Elastic Fracture Mechanics (LEFM) and lubrication theory within a reasonable degree of accuracy. The simulation results indicate that even in the very low-porosity (1–2 %) and low-permeability ($${10}^{-18}\ {\mathrm{m}}^{2}- {10}^{-19}\ {\mathrm{m}}^{2}$$

10

-
18

m

2

-

10

-
19

m

2

) crystalline rocks, which are usually the target of EGS, fluid-loss into the matrix and unsaturated flow impacts the formation breakdown pressure and the post-breakdown pressure trends. Therefore, underestimation of such parameters in numerical modeling can lead to significant underestimation of breakdown pressure. The simulation results also indicate the importance of implementing wellbore solvers for considering the effect of system compressibility and pressure drop due to friction in the injection line. The varying injection rate as a result of decompression at the instant of fracture initiation affects the fracture size, while the entry friction at the connection between the well and the initial notch may cause an increase in the measured breakdown pressure.
Some results of Fekete–Szegö type for Bavrin’s families of holomorphic functions in $${\mathbb {C}}^{n}$$
Authors: Długosz Renata , Liczberski Piotr 
Published: March 2021

AbstractIn the paper there is considered a generalization of the well-known Fekete–Szegö type problem onto some Bavrin’s families of complex valued holomorphic functions of several variables. The definitions of Bavrin’s families correspond to geometric properties of univalent functions of a complex variable, like as starlikeness and convexity. First of all, there are investigated such Bavrin’s families which elements satisfy also a (j, k)-symmetry condition. As application of these results there is given the solution of a Fekete–Szegö type problem for a family of normalized biholomorphic starlike mappings in$${\mathbb {C}}^{n}.$$Cn.
The action of Young subgroups on the partition complex
Authors: Arone Gregory Z. , Brantner D. Lukas B. 
Published: March 2021

AbstractWe study the restrictions, the strict fixed points, and the strict quotients of the partition complex$|\Pi_{n}|$|Πn|, which is the$\Sigma_{n}$Σn-space attached to the poset of proper nontrivial partitions of the set$\{1,\ldots,n\}${1,…,n}.We express the space of fixed points$|\Pi_{n}|^{G}$|Πn|Gin terms of subgroup posets for general$G\subset \Sigma_{n}$G⊂Σnand prove a formula for the restriction of$|\Pi_{n}|$|Πn|to Young subgroups$\Sigma_{n_{1}}\times \cdots\times \Sigma_{n_{k}}$Σn1×⋯×Σnk. Both results follow by applying a general method, proven with discrete Morse theory, for producing equivariant branching rules on lattices with group actions.We uncover surprising links between strict Young quotients of$|\Pi_{n}|$|Πn|, commutative monoid spaces, and the cotangent fibre in derived algebraic geometry. These connections allow us to construct a cofibre sequence relating various strict quotients$|\Pi_{n}|^{\diamond} \mathbin {\operatorname* {\wedge }_{\Sigma_{n}}^{}} (S^{\ell})^{\wedge n}$|Πn|⋄∧Σn(Sℓ)∧nand give a combinatorial proof of a splitting in derived algebraic geometry.Combining all our results, we decompose strict Young quotients of$|\Pi_{n}|$|Πn|in terms of “atoms”$|\Pi_{d}|^{\diamond} \mathbin {\operatorname* {\wedge }_{\Sigma_{d}}^{}} (S^{\ell})^{\wedge d}$|Πd|⋄∧Σd(Sℓ)∧dfor$\ell$ℓodd and compute their homology. We thereby also generalise Goerss’ computation of the algebraic André-Quillen homology of trivial square-zero extensions from$\mathbf {F}_{2}$F2to$\mathbf {F}_{p}$Fpfor$p$pan odd prime.
Strafzumessung bei Tierschutzdelikten
Authors: Hahn Johanna 
Published: March 2021

ZusammenfassungGewerbliche Tierhalter stehen in Deutschland selten vor Gericht – jedenfalls vor Strafgerichten.
Der Beitrag beleuchtet das Urteil des LG Ulm in einem Fall der Tierquälerei in der kommerziellen Tierhaltung
und unterzieht dieses einer kritischen Würdigung. Besonderes Augenmerk ist dabei auf Fragen gerichtet,
die auch in künftigen ähnlichen Strafverfahren von Bedeutung sein werden: Wann greift §17
Nr. 2 lit. a) TierSchG (rohe Tiermisshandlung) im Umfeld der gewerblichen Tierhaltung? Welchen Einfluss
hat die Empörung der Öffentlichkeit über Tierschutzverstöße auf die Strafzumessung?
Welche Wechselwirkung besteht zwischen Tierhaltungsverbot und unbedingter Freiheitsstrafe?
Probing the Processes: Longitudinal Qualitative Research on Social Determinants of HIV
Authors: Barrington Clare , Rosenberg Alana , Kerrigan Deanna , Blankenship Kim M. 
Published: March 2021

AbstractLongitudinal qualitative research can provide rich understanding of the life circumstances of vulnerable groups who experience health inequities, of whether, how and why these circumstances change, and of how these circumstances and processes of change impact health. But, this rich understanding is not automatic and requires systematic and thoughtful approaches to data collection and analysis. The purpose of this paper is to describe two longitudinal qualitative studies embedded in mixed-methods studies of social determinants of HIV in the United States and the Dominican Republic. We compare these two studies to critically reflect on specific techniques that facilitate longitudinal and iterative data collection, management, and analysis, in particular the use of participant-specific matrices and analytic summaries across the distinct phases of the research. We conclude that combining cross-sectional and longitudinal analysis that engages with both themes and processes of change can contribute to improved contextualization and understanding of social determinants of HIV.
A comprehensive study of bloated dependencies in the Maven ecosystem
Authors: Soto-Valero César , Harrand Nicolas , Monperrus Martin , Baudry Benoit 
Published: March 2021

AbstractBuild automation tools and package managers have a profound influence on software development. They facilitate the reuse of third-party libraries, support a clear separation between the application’s code and its external dependencies, and automate several software development tasks. However, the wide adoption of these tools introduces new challenges related to dependency management. In this paper, we propose an original study of one such challenge: the emergence of bloated dependencies. Bloated dependencies are libraries that are packaged with the application’s compiled code but that are actually not necessary to build and run the application. They artificially grow the size of the built binary and increase maintenance effort. We propose DepClean, a tool to determine the presence of bloated dependencies in Maven artifacts. We analyze 9,639 Java artifacts hosted on Maven Central, which include a total of 723,444 dependency relationships. Our key result is as follows: 2.7% of the dependencies directly declared are bloated, 15.4% of the inherited dependencies are bloated, and 57% of the transitive dependencies of the studied artifacts are bloated. In other words, it is feasible to reduce the number of dependencies of Maven artifacts to 1/4 of its current count. Our qualitative assessment with 30 notable open-source projects indicates that developers pay attention to their dependencies when they are notified of the problem. They are willing to remove bloated dependencies: 21/26 answered pull requests were accepted and merged by developers, removing 140 dependencies in total: 75 direct and 65 transitive.
Thermogravimetric analysis of cancellous bone of humerus head in patients undergoing total shoulder arthroplasty
Authors: Bata András , Nöt László G. , Szabó Hajnalka , Cifra János , Lőrinczy Dénes 
Published: March 2021

AbstractPrior to shoulder replacement, the quality of cancellous bone stock of humerus head should be evaluated. Thermogravimetric analysis (TGA) has already been utilized to assess thermal stability of cancellous bone mineral, collected from the femoral head of patients with osteoarthritis and osteoporosis. Our workgroup has recently examined the thermal parameters of rotator cuff of patients undergoing reversed shoulder replacement. We hypothesized that TGA of humerus head would indicate difference in the bone quality of orthopedic and trauma patients. We also hypothesized that the calorimetric data could correlate with the grade of degenerative changes. Cylindrical subchondral humeral head samples were collected from patients subjected to reversed shoulder replacement due to orthopedic or trauma indications. Then, calorimetric parameters were measured using DTA/TG analysis. Radiological evaluation was also performed to classify the grade of osteoarthritis. In case of orthopedic samples, the calorimetric parameters indicated a moderate to severe degree of bone damage and loss of mineralization, because of the progressed osteoarthritis. Meanwhile, the trauma samples exhibited only moderate or minimal subchondral bone degeneration. DTA curves showed different patterns and indicated shifts in transition temperatures, comparing control and pathologic samples. In addition, correlation was found between the degree of osteoarthritis and calorimetric enthalpy. DTA/TG analysis of humerus head samples indicated marked differences in bone quality of orthopedic and trauma patients. Further investigation is needed to differentiate the calorimetric parameters of different layers of subchondral bone.
A political ontology for Europe: Roberto Esposito’s instituent paradigm
Authors: Fulco Rita 
Published: March 2021

AbstractThe aim of my article is to relate Roberto Esposito’s reflections on Europe to his more recent proposal ofinstituent thought. I will try to do so by focusing on three theoretical cornerstones of Esposito’s thought: the first concerns the evidence of a link between Europe, philosophy and politics. The second is deconstructive: it highlights the inadequacy of the answers of the most important contemporary ontological-political paradigms to the European crisis, as well as the impossibility of interpreting this crisis through theoretical-political categories such assovereignty. The third relates more directly to the proposal of a new political ontology, which Esposito defines asinstituent thought. Esposito’s discussion of political theology is the central theoretical nucleus of this study. This discussion will focus, in particular, on the category ofnegation, from which any political ontology that is based onpure affirmativenessorabsolute negationis criticized. In his opinion, philosophical theories developed on the basis of these assumptions have proved to be incomplete or ineffective in relation to the current European and global philosophical and political crisis. Esposito therefore perceives the urgent need to propose a line of thought that is neither negatively destituent (post-Heideggerian), nor affirmatively constituent (post-Deleuzian, post-Spinozian), but instituent (neo-Machiavellian), capable of thinking aboutorderthroughconflict(the affirmative through the negative). Provided that we do not think of the institutionstatically–in a conservative sense–butdynamically, as constantinstitutingin which conflict can become an instrument of a politics increasingly inspired by justice.
Implementation of High and Intensive Care (HIC) in the Netherlands: a Process Evaluation
Authors: van Melle A. Laura , van der Ham Alida J. , Widdershoven Guy A. M. , Voskes Yolande 
Published: March 2021

AbstractThe High and Intensive Care model (HIC) was developed to reduce coercion and improve the quality of acute mental health care in the Netherlands. This study aimed to identify drivers of change which motivate professionals and management to implement HIC, and to identify facilitators and barriers to the implementation process. 41 interviews were conducted with multiple disciplines on 29 closed acute admission wards for adult psychiatric patients of 21 mental healthcare institutions in the Netherlands. The interviews were analysed by means of thematic analysis, consisting of the steps of open coding, axial coding and selective coding. Findings reveal three major drivers of change: the combination of existing interventions in one overall approach to reduce coercion, the focus on contact and cooperation and the alignment with recovery oriented care. Facilitators to implementation of HIC were leadership, involving staff, making choices about what to implement first, using positive feedback and celebrating successes, training and reflection, and providing operationalizable goals. Barriers included the lack of formal organizational support, resistance to change, shortage of staff and use of flex workers, time restraints and costs, lack of knowledge, lack of facilities, and envisaged shortcomings of the HIC standards. Drivers of change motivate staff to implement HIC. In the process of implementation, attention to facilitators and barriers on the level of culture, structure and practice is needed.
Taxonomy and phylogeny of Aphanomycopsis bacillariacearum, a holocarpic oomycete parasitoid of the freshwater diatom genus Pinnularia
Authors: Buaya Anthony T. , Scholz Bettina , Thines Marco 
Published: March 2021

AbstractInvestigations into simple holocarpic oomycetes are challenging, because of the obligate biotrophic nature of many lineages and the periodic presence in their hosts. Thus, despite recent efforts, still, the majority of species described remains to be investigated for their phylogenetic relationships. One of these species is Aphanomycopsis bacillariacearum, the type species of the genus Aphanomycopsis. Species of Aphanomycopsis are endobiotic holocarpic parasites of diverse hosts (e.g., diatoms, desmids, dinoflagellates). All species classified in this genus were assigned to it based on the presence of branching hyphae and the formation of two generations of zoospores, of which the first one is not motile. Originally, Aphanomycopsis with its type species, A. bacillariacearum, had been classified in the Saprolegniaceae. However, the genus has undergone multiple taxonomic reassignments (to Ectrogellaceae, Lagenidiaceae, and Leptolegniellaceae) in the past. To settle the taxonomy and investigate the phylogenetic placement of Aphanomycopsis, efforts were undertaken to isolate A. bacillariacearum from its original host, Pinnularia viridis and infer its phylogenetic placement based on nrSSU (18S) sequences. By targeted isolation, the diatom parasitoid was rediscovered from Heiðarvatn lake, Höskuldsstaðir, Iceland. Phylogenetic reconstruction shows that A. bacillariacearum from Pinnularia viridis is embedded within the Saprolegniales, and largely unrelated to both diatom-infecting oomycetes in the Leptomitales (Ectrogella, Lagenisma) and those placed within the early-diverging lineages (Miracula, Diatomophthora) of the Oomycota.
Synthesis and characterization of herbicidal ionic liquids based on (4-chloro-2-methylphenoxy)acetate and phenoxyethylammonium
Authors: Ciarka Kamil , Olszewski Radoslaw , Praczyk Tadeusz , Pernak Juliusz 
Published: March 2021

AbstractTen ionic liquids containing the (4-chloro-2-methylphenoxy)acetate (MCPA) anion and domiphen derived phenoxyethylammonium cation were synthesized. The obtained compounds differed in terms of the substitution of the phenoxyethylammonium group in the ring (the presence of a methyl group in the meta or para positions and the presence of chlorine in the para position) as well as the length of the alkyl chain (from hexyl to tetradecyl). The basic physicochemical properties of the obtained ionic liquids (solubility and thermal stability) were characterized and their structures were confirmed. The herbicidal activity of the compounds was tested under greenhouse conditions using cornflower (Centaurea cyanus L.) as the test plant.