bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life and associated factors among people living with human immunodeficiency virus on highly active antiretroviral therapy in North East Ethiopia: Cross-sectional study
Authors: Mohammed Solomon Ahmed , Yitafr Minilu Girma , Workneh Birhanu Demeke , Hailu Abel Demerew 
Published: March 2021

Introduction
HIV/AIDS remains a public health concern affecting millions of people across the world. Although the health-related quality of life (HRQoL) of patients living with HIV has significantly improved after treatment, its chronicity makes the HRQoL uncertain. This study assessed factors associated with the health-related quality of life among people living with HIV/AIDS on HAART in North-East Ethiopia.

Methods
An institutional-based cross-sectional study was conducted from March to April 2018, and systematic random sampling was used to select 235 participants who were on HAART. HRQoL was assessed using the Medical Outcomes Study HIV Health Survey. Descriptive and multiple linear regression analysis were computed using the statistical package for social sciences version 20.

Results
The study revealed one-factor structure and had good overall internal consistency (78.5). Over one-third (42.6%; 95% CI; 36.2%, 48.9%) of participants had good HRQoL. The least HRQoL mean score was found for cognitive functioning 32.21(±19.78), followed by social functioning 40.58(±29.8). Factors associated with the overall HRQoL were 25–45 years of age (β = − 3.55, 95% CI;-6.54, -0.55), working in private sector (β = -5.66, 95% CI;-9.43, -1.88), government (β = -4.29, 95% CI;-7.83, -0.75) and self-employment (β = -8.86, 95% CI;-13.50, -4.21), 100–200 (β = − 4.84, 95% CI;-9.04, -0.63) and 201–350 CD4 at the time of diagnosis (β = − 7.45, 95% CI;-11.73, -3.16), 351–500 current CD4 level (β = 8.34, 95% CI;5.55, 11.41), 6–10 years of disease duration (β = -8.28, 95% CI;-12.51, -4.04), WHO stage II (β = -4.78, 95% CI;-8.52, -1.04) and III (β = 3.42, 95% CI;0.06, 6.79) during treatment initiation and not taking of Cotrimoxazole prophylaxis (β = -5.79, 95% CI;-8.34, -3.25).

Conclusions
High proportion of participants had a poor HRQoL. Routine assessment and appropriate interventions at each visit is recommended to improve HRQoL.
The self-management work of food hypersensitivity
Authors: Jakobsen Monika Dybdahl , Obstfelder Aud , Braaten Tonje , Abelsen Birgit 
Published: March 2021

Background
Food hypersensitivity (FH) has received considerable attention in the scientific community in recent years. However, little attention has been given to the efforts people make to manage their FH. We aimed to explore these efforts by using Normalization Process Theory, which is a conceptual framework formerly used to describe the self-management ‘work’ of long-term conditions.

Methods
We carried out qualitative individual interviews with 16 women with FH. Transcripts from recorded interviews were analyzed using template analysis.

Results
16 women participated; some had diagnoses from conventional medicine (celiac disease, lactose intolerance, food allergies, irritable bowel syndrome) and some did not. Participants described carrying out several tasks, some of which were time-consuming, to manage their FH. Women who had clarified once and for all what food(s) caused symptoms, described that they could concentrate on carrying out a restricted diet, which could become routine. Conversely, participants who had not achieved such clarification described carrying out tasks to identify what food(s) caused symptoms, and to implement and evaluate a tentative diet. Participants’ descriptions also revealed a heightened vigilance when they ate food that others had prepared, and some made efforts to conceal their FH.

Conclusions
Self-management of FH may, like the self-management of other long-term conditions, imply a large workload and burden of treatment. Efforts made to conceal FH may be considered part of this workload, while help in clarifying which food(s) cause symptoms has the potential to reduce the workload.
Effect of anaerobic gymnastics exercise on vascular endothelial growth factor in obese boys
Authors: Saleh Vahid , Afroundeh Roghayye , Siahkohiyan Marefat , Asadi Asadollah 
Published: March 2021

Background Vascular endothelial growth factor (VEGF) is the most important growth factor involved in angiogenesis and appears to be mediated through exercise training, leading to increased blood lactate.
Objective To evaluate and compare the effects of anaerobic gymnastics exercise (AGE) on systemic VEGF in obese and normoweight boys.
Methods Sixty boys aged 8 to 12 years who enrolled in elementary level of gymnastics participated in this study and were randomly divided into four groups of 15 subjects each: obese AGE, obese control, normoweight AGE, and normoweight control. The control group didn’t have any exercise during the study. The experimental groups performed 45 minutes of AGE 3 times per week for 8 weeks, which included a 10-minute warm-up, 30-minute main exercises, and 5-minute cool down. Body composition characteristics and VEGF levels in saliva were measured before and after 8 weeks of training.
Results Significant changes following AGE were found in the obese group in terms of weight (-8.09%; P=0.001), body fat% (BF%) (-12.81; P=0.001), body fat weight (BFW) (-19.38; P=0.001), and lean body weight (LBW) (-3.20; P=0.001). Saliva levels of VEGF increased post-AGE in the obese (+21.64%; P=0.79) and normoweight groups (+28.22; P=0.06), but the differences were not significant. Significant differences in weight, BF%, and BFW were found in between obese AGE group with obese control, normoweight control and normoweight AGE (P˂0.05).
Conclusion Circulating VEGF concentrations slightly increase after 8 weeks of AGE in obese and normal-weight groups. Moreover, we demonstrate that weight significantly decreased in obese children after they engaged in AGE training.
Incidencia de distintas frecuencias de corte en parámetros nutritivos de pasturas de alfalfa (Medicago sativa L.) de distinto grado de reposo invernal
Authors: ORDOÑEZ Vanesa , NESCIER Isabel De los Milagros , DOVIS Verónica L. , GIECO Jorge O. , BONVIN Carolina E. , RAINAUDO María Belén 
Published: March 2021

El objetivo de este trabajo fue evaluar la calidad nutricional en 3 cultivares de alfalfa, pertenecientes a diferentes grupos de reposo invernal (GRI), sometidos a dos frecuencias de corte, durante un año del cultivo, fundamentado en que es abundante la información existente en estudios realizados en productividad, cobertura y persistencia, no así en la determinación de calidad de forraje sometidos a diferentes frecuencias de cortes y de GRI contrastantes. Se utilizaron tres cultivares (GR6-Verzy), (GR9-Mecha) y (GR10-Ruano). El diseño experimental fue de parcelas divididas con cuatro repeticiones. Se establecieron 2 tratamientos definidos por los intervalos entre cortes: T1: 25 días y T2: 35 días. Estos fueron precisados para las estaciones de primavera, verano y otoño. En invierno el intervalo fue de 45 y 55 días en T1 y T2, respectivamente. Las variables evaluadas fueron: porcentaje de materia seca (% MS), porcentaje de proteína bruta (% PB), porcentaje de fibra detergente neutro (% FDN) y porcentaje de fibra detergente ácido (% FDA). Se encontraron diferencias significativas para todas las variables nutricionales estudiadas, para ambos tratamientos. Se observó interacción entre cultivares y tratamiento para % PB. Los cultivares estudiados con diferentes GRI, no expresaron diferencias significativas en los parámetros de calidad evaluados para ninguna de las frecuencias de corte realizadas. La frecuencia de corte de 35 días arrojó los menores % PB y mayores % FDN y % FDA, por lo cual el forraje resulta para esta frecuencia de menor calidad, llevando a la disminución de la digestibilidad y aprovechamiento de la pastura para el ganado
Pharmacotherapy for weight loss in adults with type 2 diabetes: a systematic review of randomised controlled trials
Authors: Coelho Claudia , Agius Rachel , Crane James , McGowan Barbara 
Published: March 2021

Background: Clinically significant weight loss improves glycaemic control and cardiovascular disease risk in patients with type 2 diabetes (T2DM).Aim: To identify and assess the efficacy of medical treatments for weight loss in adults with T2DM.Methods: A systematic review was conducted of peer- reviewed literature between July 2004 and July 2020 via PubMed, Embase, Web of Science, medRxiv and Cochrane Central Register of Controlled Trials. Randomised controlled trials (RCTs) in English investigating medical treatments for weight loss in patients with T2DM were included. RCTs of pharmacotherapy withdrawn from the market were excluded. No minimum length of follow-up time was established. Outcomes of interest were changes from baseline in body weight (%), changes from baseline in HbA1c (%, mmol/mol) and proportion of patients who achieved ≥5% weight loss. Quality assessment was evaluated using the Jadad score.Results: Fifteen RCTs were included with a total of 4,207 participants with T2DM. Interventions included medications approved for obesity management (orlistat, liraglutide, naltrexone-bupropion and phentermine-topiramate) and other agents investigated for the primary purpose of weight loss (topiramate, metreleptin, dapagliflozin and exenatide) compared with placebo. The duration of the intervention varied from 12 to 56 weeks. Placebo-adjusted body weight loss ranged from 2.2% to 7.3%. Furthermore, 30.5–77.0% of patients achieved ≥5% weight loss. Placebo-adjusted change in glycated haemoglobin was 0.3–1.5% (3.3–16.4 mmol/mol).Conclusion: Current evidence demonstrates that pharmacotherapy for weight loss, except for leptin, is associated with weight loss and glycaemic improvement in patients with T2DM.
Sampul Depan
Authors: Nurhayati Ai 
Published: March 2021

Puji dan syukur kami panjatkan ke Hadirat Allah SWT, karena berkat Rahmat dan Hidayah-Nya kami dapat menerbitkan jurnal di bidang pendidikan, gizi, dan kuliner Tata Boga. Jurnal ini disusun sebagai wujud usaha program studi pendidikan tata boga untuk mempublikasikan karya ilmiah mahasiswa maupun dosen di bidang pendidikan, gizi, dan kuliner Tata Boga secara online. Usaha ini dilakukan berdasarkan pada surat edaran dari Dirjen DIKTI No. 2050/E/T/2011 tentang kebijakan unggah karya ilmiah dan jurnal. Kebijakan tersebut kemudian direalisasikan oleh UPI melalui kebijakan dalam bentuk program pengembangan jurnal setiap departemen dan program studi di lingkungan UPI.Jurnal ini diberi nama Media Pendidikan, Gizi, dan Kuliner. Jurnal ini akan terbit secara berkala dua kali dalam setahun, yaitu setiap bulan November dan April. Pada bulan April 2020 ini merupakan jurnal terbitan volume kesembilan dan nomor satu.Kami mengucapkan banyak terima kasih kepada semua pihak yang telah membantu terbitnya jurnal ini. Selain itu, kami pun mengucapkan terima kasih kepada para kontributor yang telah mengirimkan naskah artikel hasil penelitiannya. Semoga jurnal ini dapat terus terbit secara berkala dan memberikan sumbangan pada dunia keilmuan dan perkembangan teknologi di Indonesia.
Penegakan Hukum Pemalsuan Surat Disebabkan Penyerobotan Hak Atas Tanah
Authors: Sari Fatika , Widowaty Yeni , Suryono Leli Joko 
Published: March 2021

Hak penguasaan atas tanah dapat dibuktikan oleh sertipikat yang berlaku sebagai alat bukti kuat mengenai data fisik dan yuridis yang dimuat didalamnya. Bukti kepemilikan hak atas tanah ini sering menimbulkan sengketa yang menimbulkan perkara penyerobotan. Penyerobotan terjadi karena tindak pemalsuan surat. Pemalsuan surat sendiri merupakan salah satu tindak pidana yang di atur dalam Pasal 263 ayat (2) KUHP. Tulisan ini akan menjelaskan lebih lanjut tentang penegakan hukum pidana pemalsuan surat hak atas tanah yang disebabkan karena penyerobotan hak atas tanah. Penelitian ini menggunakan metode penelitian yuridis empiris dengan pendekatan kualitatif dengan sumber data primer dan sekunder. Hasil penelitian di temukan bahwa penegakan hukum pidana yang penulis analisis menggunakan Pasal 263 ayat (1) dan ayat (2) yang mencantumkan hukuman atau saksi paling lama enam tahun penjara. Adapun sanksi pidana penjara selama sepuluh bulan dijatuhkan terhadap terdakwa Muhardin Als Muhar sesuai dengan putusan nomor 374/Pid.B/2019/PN. Bgl. Sedangkan terdakwa Abdul Sanapudin di bebaskandari semua dakwaan sesuai dengan Putusan Nomor 424/Pid.B/2018/PN.Bgl
Estimation of breeding material of interspecific hybrids Allium ascalonicum L. and Allium cepa L.
Authors: Steinert T. V. , Teplova N. S. , Aliluev A. V. 
Published: March 2021

Relevance. Shallots are an independent botanical species. It easily crosses with onions, has a medium-sized bulb, keeps well, gives rich greens. Shallot and onion hybrids have a higher yield, less nesting, and a large bulb mass. Work on the creation of interspecific hybrids of shallots and onions has been under way since 2000.Methods. The aim of the research was to study the hybrids of Allium ascalonicum L. x Allium cepa L. and Allium cepa L. x Allium ascalonicum L. by a complex of characters in comparison with their maternal forms. Samples from the Urals were taken as initial forms for hybridization.Results. 268 promising hybrids were obtained, of which 33 were selected for further study. The results of the study showed the advantage of hybrid forms, where shallots were the parent form. A significant advantage of hybrids over parental forms was revealed in terms of yield, average and maximum bulb weight.
Nilai Kearifan Lokal Tradisi Manugal Masyarakat Dayak Meratus Kalimantan Selatan Pada Materi Geografi Bidang Lingkungan Hidup (Kajian Etnografi)
Authors: Efendi Muhammad , Sahrul Muhammad , Salma Siti 
Published: March 2021

Kalimantan Selatan mempunyai suku yang memiliki keanekaragaman dalam berbagai hal. Salah satunya adalah budaya yang berkembang dalam masyarakat adat sebagai kekayaan nasional. Masyarakat adat secara tradisi terus berpegang pada nilai-nilai lokal yang diyakini kebenaran dan kesakralannya serta menjadi pegangan hidup anggotanya yang diwariskan secara turun temurun. Nilai-nilai tersebut saling berkaitan dalam sebuah sistem. Sebagai kesatuan hidup manusia, masyarakat adat memiliki nilai sosial-budaya yang dapat dikaji untuk dikembangkan dalam pembelajaran. Masyarakat adat sangat kental dengan budaya kesetiakawanan sosial dalam melakukan segala aktivitas hidupnya. Seperti yang terjadi pada suku Dayak Meratus, Kalimantan Selatan. Terlepas dari unsur mistis yang ada di dalamnya, pemahaman tentang nilai-nilai tersebut sangat penting dimiliki oleh peserta didik, kini dan masa yang akan datang. Oleh karena itu, nilai-nilai budaya masyarakat tradisional yang dikembangkan dalam konteks kekinian, sangat penting untuk dijadikan kajian dalam pembelajaran Geografi berkaitan dengan Pendidikan Lingkungan Hidup sehingga terinternalisasi pada diri peserta didik. Tentu setelah dikaji secara ilmiah, mengapa nilai-nilai tersebut harus diwarisi oleh mereka.
Using the ORACLE Risk Score to Assess Hemorrhagic Risk in Patients with Acute Coronary Syndrome and Atrial Fibrillation
Authors: Brazhnik V. A. , Minushkina L. O. , Erlikh A. D. , Kosmacheva E. D. , Chichkova M. A. , Khasanov N. R. , Zateyshchikov D. A. 
Published: March 2021

Aim. To study the prognostic value of the ORACLE risk score for assessing the risk of bleeding in patients with acute coronary syndrome (ACS) undergoing anticoagulants for atrial fibrillation using the combined database of the ORACLE II and RECORD 3 registers.Material and methods. This analysis included patients with ACS from 2 observational studies: ORACLE II (ObseRvation after Acute Coronary syndrome for deveLopment of trEatment options; n=1803) and the RECORD-3 register (n=2370). In total, the database included 4173 patients, of which 246 (6.08%) received oral anticoagulants for atrial fibrillation. The mean age of patients was 64.7±11.9 years, 2493 (59.7%) were men. Hemorrhagic risk was assessed using the ORACLE, CRUSADE, ORBIT, and HAS-BLED risk score.Results. Patients receiving anticoagulant therapy were older (69.9±11.3 years and 64.0±12.2 years, p<0.001). Among these patients there was a larger proportion of women, and a smaller proportion of patients with ACS with ST elevation, they were more likely to have chronic heart failure, chronic kidney disease, history of stroke. Among patients receiving anticoagulants and included in the ORACLE study, the frequency of percutaneous coronary intervention was higher than in patients included in the RECORD study. In the joint database, 71 significant bleeding was recorded during the hospitalization period – 64 (1.7%) in patients without anticoagulants and 7 (2.8%) among patients taking anticoagulants (p=0.06). Over 6 months, among patients who did not receive anticoagulants, there were 97 cases of bleeding (in 2.6% of patients), in the group of patients receiving anticoagulants – 12 cases of bleeding (4.9%) – the differences in frequency were significant (p=0.029). The ORACLE risk score had the greatest prognostic value (area under the ROC curve 0.874±0.0416, sensitivity 82.7%, specificity 79.1%). The predictive value of the HAS-BLED risk score was slightly lower (area under the ROC curve 0.710±0.0360, sensitivity 63.2%, specificity 56.8%). The value of the CRUSADE risk score (area under the ROC curve 0.612±0.0269, sensitivity 53.7%, specificity 59.5%) and ORBIT risk score (area under the ROC curve 0.606±0.0457, sensitivity 62.5%, specificity 58.3%) were lower (p<0.001 for all scales).Conclusion. The use of the ORACLE bleeding risk score can be recommended for patients with ACS requiring anticoagulant therapy.
Pharmacokinetics and Pharmacogenetics of Dabigatran
Authors: Savinova A. V. , Dobrodeeva V. S. , Petrova M. M. , Nasyrova R. F. , Shnayder N. A. 
Published: March 2021

Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists. However, pharmacokinetics and pharmacogenetics of dabigatran are variable. This can affect both effectiveness and safety of anticoagulant therapy. It is considered that CES1 enzyme and P-glycoprotein (CES1 and ABCB1 genes accordingly) play important role in pharmacokinetics of dabigatran etexilate. UDP-glucuronosyltransferase enzymes UGT2B15, UGT1A9, UGT2B7 (UGT2B15, UGT1A9, UGT2B7 genes accordingly) take part in the metabolism of active dabigatran. Presence of these gene’s single-nucleotide variants (SNV) can affect effectiveness and safety of dabigatran etexilate usage. The goal of this review is analysis of associated researches of SNV genes CES1 and ABCB1 and search for new candidate genes that reveal effectiveness and safety of dabigatran etexilate usage.Materials and methods. The search for full-text publications in Russian and English languages containing key words “dabigatran etexilate”, “dabigatran”, “pharmacokinetics”, “effectiveness”, “safety” was carried out amongst literature of the past twenty years with the use of eLibrary, PubMed, Web of Science, OMIM data bases. Pharmacokinetics and pharmacogenetics of dabigatran etexilate are considered in this review. The hypothesis about UDP-glucuronosyltransferase enzymes influence on dabigatran metabolism was examined. Nowadays more than 2000 SNV CES1 and ABCB1 genes are identified, but their potential influence on pharmacokinetics of dabigatran etexilate and its active metabolite (dabigatran) in clinical practice needs to be further researched. Role of SNV UDP-glucuronosyltransferase genes (UGT2B15, UGT1A9, UGT2B7) in dabigatran’s effectiveness and safety is not explored enough. However, UGT2B15 gene can be a potential candidate gene for research on safety of this drug.
Comparative Assessment of the Clinical Course, Drug Therapy and Outcomes in Myocardial Infarction without or with Obstructive Coronary Artery Disease
Authors: Fomina O. A. , Yakushin S. S. 
Published: March 2021

Aim. To compare clinical features, drug therapy and outcomes in patients with non-obstructive and obstructive coronary artery infarction.Material and methods. The study included 206 patients with a diagnosis of myocardial infraction (MI). According to the results of coronarography, patients were divided into two groups: 103 patients (group 1; MINOCA) did not have obstructive involvement coronary arterial (CA): in 67 (65%) of cases, there is no data for atherosclerotic coronary bed lesion, another 36 (35%) – have CA stenosis up to 50%. 103 patients (group 2) with MI and obstructive CA (MIOCA). The patients of the second group in 100% of cases underwent endoprosthesis of CA, the affection of which caused infraction. The second group was selected by the copy method comparatively to the first group. The analysis of clinical peculiarities, medication and outcomes was made in these groups of patients, in particular.Results and conclusions. The clinical “portrait” of patients with MI in nonobstructive and obstructive CA involvement did not differ significantly. Higher serum level of total cholesterol (5.6 [4.4;6.2] vs 5.1 [4.4;5.8] mmol/l р=0.04) and cholesterol of low-density lipoproteins (2.9 [2.2;3.5] vs 2.5 [2.1;2.9] mmol/l р=0,01), troponin [2.8 [0.7;15.0] vs 1.2 [0.1;7.7] ng/ml р=0.02) were identified in blood tests of MIOCA patients in the comparison with MINOCA group. Antero-lateral (р=0.02) and unspecified localization of MI (р=0.03) was more frequent in the MINOCA group. The differences in therapeutic approach were manifested in the more frequent prescription of double antiplatelet therapy: (99.0% vs 80.6% р< 0.01) in MIOCA patients. In the MINOCA group а more frequent prescription of dihydropyridine calcium channel blocking agents was registered (23.3% vs 2.9% р<0.01). The unfavorable outcomes for MINOCA is comparable to MIOCA in terms of the incidence of hospital mortality (2.9% against 4.9%; p>0.05), annual mortality (5.1% against 7.8%; p>0.05), and combined endpoint (6.8% against 10.7%; p>0.05).Conclusion. Despite the similarity of the clinical presentations of MI with obstructive and nonobstructive CA involvement in real clinical practice, there are differences in the pharmacotherapeutic approach in the management of these groups of patients. MINOCA is characterized by an unfavorable outcomes similar to MIOCA.