bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perubahan kalor jenis campuran bahan mortar dengan penambahan pasir besi
Authors: Hartono Hartono , Sugito Sugito , Abdullatif Farzand 
Published: June 2021

Potensi energi matahari yang berupa kalor dapat digunakan untuk berbagai kebutuhan, antara lain untuk pengeringan, proses destilasi air laut, atau sebagai pamanas water heater. Optimalisasi media penyerap kalor perlu dilakukan guna meningkatkan kemampuannya. Salah satu variabel yang berpengaruh pada kemampuan penyerapan kalor adalah nilai kalor jenis (c). Keberadaan unsur logam di dalam pasir perlu diteliti untuk mengetahui kemampuannya dalam meningkatkan penyerapan kalor. Kehadiran pasir besi pada campuran bahan pembuat mortar sebagai media penyerap kalor perlu diteliti. Penelitian ini dilakukan secara eksperimental dengan membuat 10 kelompok sampel mortar. Kelompok sampel dibedakan oleh komposisi campuran pasir sungai dan pasir besi yang digunakan sebagai bahan utama. Variasi campuran dibuat dengan perbandingan massa antara pasir sungai dengan pasir besi sebagai berikut: 100:0; 90:10; 80:20; 70:30; 60:40: 50:50; 40:60; 30:70; 20:80 dan 10:90. Sampel mortar yang diuji dibuat dengan ukuran (2 x 1 x 1) cm3. Pengujian dilakukan menggunakan kalorimeter bomb. Hasil pengujian diperoleh nilai kalor jenis terendah sebesar 1359,08 J/kgoC pada sampel dengan perbandingan campuran pasir sungai dan pasir besi 60:40. Sementara nilai kalor jenis tertinggi pada sampel tanpa pasir besi (100:0) dengan nilai 3555,76 J/kgoC. Berdasarkan hasil pengujian, penambahan pasir besi dapat menurunkan kalor jenis pada media mortar.
Enhanced Recovery After Primary Total Hip and Knee Arthroplasty
Authors: Morrell Aidan T. , Layon Daniel R. , Scott Michael J. , Kates Stephen L. , Golladay Gregory J. , Patel Nirav K. 
Published: June 2021

Background:Enhanced Recovery After Surgery (ERAS) has become increasingly implemented to reduce costs, to increase efficiency, and to optimize patient outcomes after a surgical procedure. This study aimed to systematically review the effect of ERAS after primary elective total hip arthroplasty (THA) or total knee arthroplasty (TKA) on hospital length of stay, total procedure-related morbidity, and readmission.Methods:A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and with guidance from the Cochrane Handbook for Systematic Reviews of Interventions. MEDLINE, Embase, and Cochrane databases were searched from inception (1946 for MEDLINE and 1974 for Embase; Cochrane is a composite of multiple databases and thus does not report a standard inception date) until January 15, 2020. Prospective nonrandomized cohort studies and randomized controlled trials comparing adult patients undergoing elective primary THA or TKA with ERAS or traditional protocols were included. Articles examining outpatient, nonelective, or revision surgical procedures were excluded. Two reviewers independently assessed the risk of bias and extracted data. The primary outcome was length of stay. The secondary outcomes included total procedure-related morbidity and readmission.Results:Of the 1,018 references identified (1,017 identified through an electronic search and 1 identified through a manual search), 9 individual studies met inclusion criteria. Data were reported from 7,789 participants, with 2,428 receiving ERAS and 5,361 receiving traditional care. Narrative synthesis was performed instead of meta-analysis, given the presence of moderate to high risk of bias, wide variation of ERAS interventions, and inconsistent methods for assessing and reporting outcomes among included studies. Adherence to ERAS protocols consistently reduced hospital length of stay. Few studies demonstrated reduced total procedure-related morbidity, and there was no significant effect on readmission rates.Conclusions:ERAS likely reduced the length of stay after primary elective THA and TKA, with a more pronounced effect in selected healthier patient populations. We found minimal to no impact on perioperative morbidity or readmission. The quality of existing evidence was limited because of study heterogeneity and a significant risk of bias. Further high-quality research is needed to definitively assess the impact of ERAS on total joint arthroplasty.Level of Evidence:TherapeuticLevel II. See Instructions for Authors for a complete description of levels of evidence.
Successful Limb Salvage Using an Orthoplastic Approach of Type IIIB Open Injuries of the Shoulder
Authors: Velmurugesan Purnaganapathi Sundaram , Devendra Agraharam , Ramkumar Sanjai , Dheenadhayalan Jayaramaraju , Rajasabapathy Shanmuganathan , Rajasekaran Shanmuganathan 
Published: June 2021

Case:
We report 3 adult men (aged 28, 34, and 71 years) with successfully salvaged mangled injuries around the shoulder with high threshold for amputation. Assessment by Mangled Extremity Severity Score, Ganga Hospital Open Injury Severity Score, and Orthopaedic Trauma Association—Open Fracture Classification open injury scores predicted amputation. However, extended salvage was performed by orthoplastic approach. Two of them had superior shoulder suspensory complex (SSSC) injury. The QuickDASH score was high in 2 patients with SSSC injury and a good score in the third patient who achieved good shoulder motion.

Conclusion:
“Orthoplastic approach” achieves successful limb salvage in severely mangled shoulder injuries. Volume of muscle crush injury and double disruption of SSSC injury were the main determinants of outcome.
Introducing the “Bleeding Team”: Urgent Reconstruction of an Open Fracture in a Patient Receiving Acenocoumarol
Authors: Bareka Metaxia , Ntalouka Maria P. , Kolonia Konstantina , Koutalos Antonios A. , Hantes Michael , Arnaoutoglou Eleni 
Published: June 2021

Case:
An elderly, polytrauma patient receiving vitamin K antagonist (VKA) for atrial fibrillation required immediate surgery for open distal tibial fracture. As the initial reversal with vitamin K and fresh frozen plasma by the trauma team was ineffective, the “Bleeding Team” was convened and administrated the appropriate four-factor prothrombin complex regimen, reversing the VKA in a timely manner. Surgery was performed under peripheral nerve blockade subsequently. The postoperative course of the patient was uneventful.

Conclusion:
The individualized approach and the multidisciplinary experts' team guidance is of outmost importance in patients who are treated with anticoagulants and present for nonelective surgery.
The trends of uveal melanoma research in the past two decades and future perspectives.
Authors: Elubous Khaled Ali , Alebous Ali Daoud , Abous Hebah Ali , Elubous Rawan Ali 
Published: June 2021

Abstract
PURPOSE Evaluation of the research trends in uveal melanoma in the past two decades.METHODS Data were extracted from the Web of Science database website. VOSviewer and Citespace software were used to analyze the retrieved data. RESULTS The leading country in terms of output and international collaboration is the United States. Research interest in genetic mutations, molecular pathways, and immunotherapy was remarkable in recent years. Most of the top ten journals are specialized in ophthalmology. In recent years the hotspots include future perspectives, BAB1 mutation, therapeutic target, and systematic reviews. The keywords with the strongest citation bursts are immunotherapy, outcome, and in situ hybridization. CONCLUSION The output of uveal melanoma research increased during the past two decades. Future research foci may include exploring different mutations role, immunotherapy, molecular alterations, and finding ideal clinical biomarkers.
The Effect of Extracorporeal Shock Wave Therapy (ESWT) In Acute Traumatic Complete (AIS A) And Incomplete (AIS B-D) Cross-Sectional Lesions On Motor And Sensory Function Within Six Months After Injury: A Two-Arm Three-Stage Adaptive, Prospective, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Leister Iris , Mittermayr Rainer , Mattiassich Georg , Aigner Ludwig , Haider Thomas , Machegger Lukas , Kindermann Harald , Grazer-Horacek Anja , Holfeld Johannes , Schaden Wolfgang 
Published: June 2021

Abstract
Background: The pathological mechanism in acute spinal cord injury (SCI) is dual sequential: the primary mechanical lesion and the secondary injury due to a cascade of biochemical and pathological changes initiated by the primary lesion. Therapeutic approaches have focused on modulating the mechanisms of secondary injury. Despite extensive efforts in the treatment of SCI, there is yet no causal, curative treatment approach available.Extracorporeal shock wave therapy (ESWT) has been successfully implemented in clinical use. Biological responses to therapeutic shock waves include altered metabolic activity of various cell types due to direct and indirect mechanotransduction leading to improved migration, proliferation, chemotaxis, modulation of the inflammatory response, angiogenesis and neovascularization thus inducing rather a regeneration than repair.Objective: The aim of this clinical study is to investigate the effect of ESWT in humans within the first 48 hours after an acute traumatic SCI, with the objective to intervene in the secondary injury phase in order to reduce the extent of neuronal loss.Study design: Two-arm three-stage adaptive, prospective, multi-center, randomized, double-blind, placebo-controlled study.Methods: The study has been initiated in July 2020 and a total of 82 patients with acute traumatic SCI will be recruited for the first stage in 15 participating hospitals as part of a two-armed three-stage adaptive trial design. The focused ESWT (energy flux density: 0.1 - 0.19 mJ/mm2, Frequency: 2-5 Hz) is applied once at the level of the lesion, five segments above / below and on the plantar surface of both feet within the first 48 hours after trauma.The degree of improvement between the follow-up examinations over six months in motor and sensory function is the primary endpoint of the study. Secondary endpoints include routine blood chemistry parameters, the degree of spasticity, the ability to walk, urological function, quality of life, and the independence in everyday life.Hypothesis: The application of ESWT activates the nervous tissue regeneration involving a multitude of various biochemical and cellular events and leads to a decreased neuronal loss. ESWT might contribute to an improvement in the treatment of acute traumatic SCI in future clinical use.ClinicalTrials.gov identifier: NCT04474106
Differential Impacts of Ridesharing on Alcohol-related Crashes by Socioeconomic Municipalities: Rate of Technology Adoption Matters
Authors: Blazquez Carola , Laurent José Guillermo Cedeño , Nazif-Munoz José Ignacio 
Published: June 2021

Abstract
Background: With the introduction of ridesharing through cell phone applications, the shape of transport systems has changed dramatically. An emergent group of studies have examined the extent under which ridesharing may decrease alcohol-related crashes in countries such as United States, United Kingdom, Canada, and Chile. Virtually all existent studies have assumed that ridesharing is equally distributed across socioeconomic groups, potentially masking differences across them. In this study, we exploit differences across different socioeconomic groups of municipalities in a highly segregated city such as Santiago, Chile to test whether, in the first year of Uber, this transport service was associated with changes in rates of fatal and injury alcohol-related crashes within municipalities. We used this period because Uber could only be paid with credit card. In Chile, this device is limited almost exclusively to high socioeconomic individuals.Methods: We apply spatial and rate ratio statistical analyses. Results: In both analyses, we find that the first year of Uber in Santiago is associated with significant rate ratio decreases (RR = 0.71 [95% Confidence Interval (C.I.) 0.56, 0.89]) in high socioeconomic municipalities in all alcohol-related crashes and null (RR = 1.10 [95% C.I. 0.97, 1.23]) increases in low socioeconomic municipalities. No concomitant associations were observed in fatal alcohol-related crashes regardless of the socioeconomic municipality group.Conclusions: One interpretation for the decline in alcohol-related crashes in high socioeconomic municipalities is that Uber may be a substitute form of transport for those individuals who have access to credit cards, and thus, could afford to pay for this service at the time they have consumed alcohol. Slight increases of alcohol-related crashes in low socioeconomic municipalities suggest that this association may be a function of alcohol consumption, in tandem with limited access to public transport alternatives within these territories.
Less Intensive 1 (LI1) Trial: A Randomized Phase II/III Clinical Trial in Approximately 1000 Elderly Patients With Acute Myeloid Leukaemia (AML) Deemed Not Suitable for Intensive Chemotherapy
Authors: Thomas Ian , Dennis Mike , Upton Laura , Ariti Cono , Russell Nigel , Hills Robert , Copland Mhairi , Burnett Alan 
Published: June 2021

Abstract
BackgroundAcute myeloid leukaemia (AML) is a heterogeneous disease where outcome is substantially influenced by age. Over the last 30-40 years, significant improvements have been made in survival for younger patients (those under 60). However, with the median age of the disease at diagnosis at 65 years, outcome in older patients has improved much less. Additionally, many elderly patients are not considered suitable for intensive chemotherapy and the current standard treatment is considered unsatisfactory. MethodsLI1 will evaluate several relevant therapeutic questions in AML patients over 60 years of age for whom intensive chemotherapy is not considered suitable. Patients are invited to enter a randomized comparison of standard therapy (LD Ara-C) versus a novel treatment. A number of different treatment options are available at any one time, but there is no comparison between novel agents. If, at initial review, a novel agent is deemed unlikely to demonstrate the required improvement, it may be removed from the protocol and replaced with another novel agent, via protocol amendment. Agents are initially entered into a phase II comparison against standard of care - where an agent is considered promising at interim review (based on remission rates), the randomisation may be extended to a fully powered phase III comparison based on survival. Agents which may prolong survival or improve remission rates will also be required to demonstrate equivalence or better of quality of life in patients – therefore, quality of life assessments are undertaken throughout, in each arm. DiscussionEven when less intensive treatment options are delivered, the outcomes are not satisfactory. The NCRI AML working group has a strong network, required for delivery of this trial program. The UK network is augmented by international collaborative groups, most notably from New Zealand and Denmark. The use of the Pick-a-Winner design improves efficiency and speed of review of the available novel agents with the aim of benefitting the increasing number of patients in this age group.Trial registration: ISCRTN40571019, EUDRACT2011-000479-19 (12th May 2011)
Elevated liver enzymes of newly-diagnosed pediatric celiac patients- a prospective-observational study
Authors: Regev Asaf , Ben-Tov Amir , Feler Anat Yerushalmy - , Weintraub Yael , Lev Hadar Moran , Cohen Shlomi , Amir Achiya 
Published: June 2021

Abstract
ObjectivesCeliac disease clinical presentation is constantly changing. We set to determine the prevalence of elevated transaminases in newly diagnosed celiac patients, and to evaluate this sub-group of patients for associated clinical and laboratory findings and assess their natural course of disease following therapeutic diet initiation.MethodsWe conducted a prospective-observational study of all newly-diagnosed pediatric celiac patients, between August 2016 – April 2018, in a pediatric gastroenterology clinic. Clinical data, anthropometrics and blood test results were recorded at diagnosis and at three, six and twelve months of follow-up. We compared patients with normal and elevated transaminases at diagnosis. ALT threshold was set at 24 U/l.ResultsOf 125 newly-diagnosed celiac patients, 31 (24.8%) had elevated ALT at diagnosis; two (1.6%) with over 3xULN. Patients with elevated ALT at diagnosis were significantly younger (mean age 5.5 (SD- 3.4) vs 7.3 (SD- 3.7) years, p < 0.01) and more commonly presented with diarrhea (32.3% vs. 14.9%, p = 0.03). 80% of patients with elevated ALT levels, normalized their ALT within 3 months and all within one year. Following gluten free diet initiation, patients with elevated ALT had similar clinical course, growth, serology normalization rate, and laboratory results, compared to patients with normal ALT over a one year follow up. A single patient was simultaneously co-diagnosed with celiac disease and auto-immune hepatitis.ConclusionsClinically significant ALT abnormalities are rare among newly diagnosed pediatric celiac patients. Significant elevations failing to normalize on gluten free diet, should raise concern of a concomitant primary liver disease and warrant further investigations.
The Impact of Intra-Uterine Manipulators on Outcome and Recurrence Patterns of Endometrial Cancer Patients Undergoing Minimally Invasive Surgery
Authors: Laskov Ido , Michaan Nadav , Kogan Liron , Zeng Xing , Salvador Shannon , Jardon Kris , Lau Susie , Gilbert Lucy , Gotlieb Walter H. , Kessous Roy 
Published: June 2021

Abstract
PurposeTo evaluate the use of an intrauterine manipulator on the oncologic outcome of women who had minimally invasive surgery for endometrial cancer. MethodsRetrospective analysis of consecutive patients who were operated with or without the use of an intrauterine manipulator. Univariate and multivariate analysis were used to adjust for possible confounders. Results699 patients were included, of whom 220 (32.8%) were operated with an intrauterine manipulator. The median follow-up was 44 months (range, 29-67). Disease-free survival was similar between groups. 19 (8.8%) patients had positive cytology in the manipulator group vs. 21 (4.4%) in the comparison group (p=0.02). Total recurrence rate was similar between the groups (12.3% vs. 11.9%; p = 0.8). Vaginal vault recurrence was the most common site of recurrence with higher incidence in the manipulator group (4.5% vs. 1.3%; p=0.007). Sub-group analysis of patients who did not receive adjuvant treatment showed higher recurrence rate (8.3% vs. 3%; p=0.023) and worse disease-free survival (p=0.01) for the manipulator group. After controlling for other variables, the use of a manipulator did not affect the risk of recurrence for the whole cohort (HR, 1.28; 95% CI, 0.7-2.1, p=0.3) and for the sub-group of patients who did not receive adjuvant treatment (HR, 2.47; 95% CI, 0.8-7, p=0.08).ConclusionThe use of a manipulator during surgery for endometrial cancer increases the risk of positive cytology as well as vaginal vault recurrences, but it does not reduce the disease-free and overall survival of patients.
Assesment of prospective geological hazards in Torrevieja-La Mata coast (Western Mediterranean) based on Pleistocene and Holocene events
Authors: Torres Trinidad , Ortiz José E. , Mediavilla Rosa , Sánchez-Palencia Yolanda , Santisteban Juan Ignacio , Vega-Panizo Rogelio 
Published: June 2021

Abstract
The coastal zone in which the lagoons of La Mata and Torrevieja (Eastern Spain) developed can be described as a compilation of geo-hazards typical of the Mediterranean realm. This study has focused mainly on those linked to recent tectonics. Extensive use of the amino acid racemization dating method allowed us to establish the evolution of all the geomorphological units differentiated in the area, the most striking manifestation being at the La Mata Lagoon Bar, where MIS 5 deposits settled on MIS 7 sediments along a marked erosive unconformity, thereby attesting coastal uplift between these two stages. In addition, recent uplift processes were reflected on stepped abrasion platforms and, in some cases, enormous boulders were transported over these platforms by extreme surge waves. Furthermore, we obtained feasible evidence that, during the end of MIS 5, an earthquake with an offshore epicenter linked to Torrevieja Fault, Bajo Segura Fault or the set of faults linked to the former, was responsible for tsunami surge deposits represented in accumulations of randomly arranged and well preserved Glycymeris and Acanthocardia shells. Recent catastrophic effects linked to the earthquakes were also detected. In this regard, comparison of the paleontological and taphonomic analyses allowed us to discern between wave and tsunami surge deposits. Therefore, evidence of these hazards undoubtedly points to important future (and present) erosive and/or catastrophic processes, which are enhanced by the presence of tourist resorts and salt-mining industry. Thus, these sites are also threatened by future increases in sea level in the context of warmer episodes, attested by raised marine fossil deposits. At the north of Cervera Cape, beaches will be eroded, without any possibility of sediment input from the starved Segura River delta. South of this cape, waves (and tsunamis) will erode the soft rocks that built up the cliff, creating deep basal notches and causing rockfall and the collapse of the overlying buildings.
The Dicyano Compound Induces Autophagic or Apoptotic Cell Death Via Twıst/C-Myc Axis Depending on Metastatic Characteristics of Breast Cancer Cells
Authors: ALVUR Ozge , KUCUKSAYAN Hakan , BAYGU Yasemin , KABAY Nilgun , GOK Yasar , AKCA Hakan 
Published: June 2021

Abstract
Breast cancer is a heterogeneous disease which has distinct subtypes and therefore development of novel targeting treatments to fight aganist breast cancer is needed. Although autophagy and apoptosis considered as the major programmed cell death mechanisms are among the current target mechanisms, there are some difficulties in clinical treatment such as the development of drug resistance and cancer recurrence. Therefore it is important that illumination of distinctive mechanisms between cancer types for development novel treatment strategies. In this study, we examined the anti-proliferative effects of the triazole linked galactose substituted dicyano compound (hereafter referred to as the dicyano compound (the DC)) on two different breast cancer cell lines, MDA-MB-231 and MCF-7. We determined that response of each cell lines to the DC was different, since autophagy was induced in MDA-MB-231 and apoptosis was induced in MCF-7. For this reason, we hypothesized that these different responses may be due to the different characteristics of the cells and evaluated effects of aggresiveness degrees of both cell lines on response to the DC. As a result of our analysis, we determined that c-Myc regulation in both cell lines was different upon the DC treatment depending on expression of Twist, an epithelial-to-mesenchymal transition (EMT) mediator. Therefore, we suggest that Twist/c-Myc axis may have a role in different response to the DC-induced cell death pathways in breast cancer subtypes.