bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and Acceptability of Collecting Passive Smartphone Data for Potential Use in Digital Phenotyping Among Family Caregivers and Patients With Advanced Cancer
Authors: Odom J. Nicholas , Lee Kyungmi , Currie Erin R. , Allen-Watts Kristen , Harrell Erin R. , Bechthold Avery C. , Engler Sally , Curry Kayleigh , Kamal Arif H. , Ritchie Christine S. , Demiris George , Wright Alexi A. , Bakitas Marie A. , Azuero Andres 
Published: January 2025

PURPOSE
Modeling passively collected smartphone sensor data (called digital phenotyping) has the potential to detect distress among family caregivers and patients with advanced cancer and could lead to novel clinical models of cancer care. The purpose of this study was to assess the feasibility and acceptability of collecting passive smartphone data from family caregivers and their care recipients with advanced cancer over 24 weeks.

METHODS
This was an observational feasibility study. Family caregivers and patients with advanced cancer were recruited through clinic or via social media and downloaded a digital phenotyping application (Beiwe) to their smartphones that passively collected sensor data over 24 weeks. Feasibility was evaluated by quantifying enrollment and retention and the quantity of acquired data. Acceptability was assessed through post-24 week qualitative interviews.

RESULTS
Of 178 caregiver and patient dyads approached, 22.5% of caregivers (n = 40) and 10.1% of patients (n = 18) both consented to the study and successfully downloaded the application, with most recruited through social media (93%). Of 24 weeks (168 days), the median number of days that data were received was 141 days. Interviews yielded three themes: (1) experiences with study procedures were generally positive despite some technical challenges; (2) security and privacy concerns were minimal, mitigated by clear explanations, trust in the health care system, and privacy norms; and (3) a clinical model that used passive smartphone monitoring to automatically trigger assistance could be beneficial but with concern about false alarms.

CONCLUSION
This pilot study of collecting passive smartphone data found mixed indicators of feasibility, with suboptimal enrollment rates, particularly via clinic, but positive retention and data collection rates for those who did enroll. Participants had generally positive views of passive monitoring.
Analog-based forecasting of turbulent velocity: Relationship between unpredictability and intermittency
Authors: Frogé E. , Granero-Belinchón C. , Roux S. G. , Garnier N. B. , Chonavel T. 
Published: January 2025

Abstract
This study evaluates the performance of analog-based methodologies to predict, in a statistical way, the longitudinal velocity in a turbulent flow. The data used comes from hot-wire experimental measurements from the Modane wind tunnel. We compared different methods and explored the impact of varying the number of analogs and their sizes on prediction accuracy. We illustrate that the innovation, defined as the difference between the true velocity value and the prediction value, highlights particularly unpredictable events that we directly link with extreme events of the velocity gradients and so to intermittency. A statistical study of the innovation indicates that while the estimator effectively seizes linear correlations, it fails to fully capture higher-order dependences. The innovation underscores the presence of intermittency, revealing the limitations of current predictive models and suggesting directions for future improvements in turbulence forecasting.
Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance
Authors: García-Tejera Rodrigo , Tian Jing-Yi , Amoyel Marc , Grima Ramon , Schumacher Linus J. 
Published: January 2025

ABSTRACT
To maintain and regenerate adult tissues after injury, division and differentiation of tissue-resident stem cells must be precisely regulated. It remains elusive which regulatory strategies prevent exhaustion or overgrowth of the stem cell pool, whether there is coordination between multiple mechanisms, and how to detect them from snapshots. In Drosophila testes, somatic stem cells transition to a state that licenses them to differentiate, but remain capable of returning to the niche and resuming cell division. Here, we build stochastic mathematical models for the somatic stem cell population to investigate how licensing contributes to homeostasis. We find that licensing, in combination with differentiation occurring in pairs, is sufficient to maintain homeostasis and prevent stem cell extinction from stochastic fluctuations. Experimental data have shown that stem cells are competing for niche access, and our mathematical models demonstrate that this contributes to the reduction in the variability of stem cell numbers but does not prevent extinction. Hence, a combination of both regulation strategies, licensing with pairwise differentiation and competition for niche access, may be needed to reduce variability and prevent extinction simultaneously.
Generation Y female consumers’ perceived value of beauty vlogs: path analysis
Authors: Bevan-Dye Ayesha Lian 
Published: January 2025

The beauty sector is widely recognised for being among the earliest adopters of social media marketing and for acknowledging the potential of social media influencers. A beauty vlogger refers to an individual who has attracted a significant number of followers on a video-based social media platform. Although academic literature is increasingly focusing on social media influencer marketing, there is demand for additional research, particularly on YouTube vlogs, regarding their impact on beauty product consumption among Generation Y female consumers. The goal of this study was to identify the elements that contribute to Generation Y female consumers’ assessment of the perceived value of beauty vlogs on YouTube. A structured electronic questionnaire was used to gather data from a sample of 340 females, 18 years of age or older, living in South Africa. The results infer that Generation Y female consumers perceive beauty vlogs on YouTube as informative, entertaining, credible and of value. Path analysis revealed that beauty vlog informativeness, entertainment value and credibility explain 69% of the variance in Generation Y females’ perceived value of beauty vlogs on YouTube. The findings underscore the relevance of beauty product marketers collaborating with beauty product influencers on YouTube when targeting Generation Y female consumers.
Cancer Cachexia: Innovations in Pharmacotherapy for Terminal-Stage Patients - Review of the latest reports
Authors: Witowska Kinga , Sacher Karolina , Hosseinnejad Negar , Biskupski Mikolaj , Turemka Mariola , Mandziuk Aneta , Korotko Urszula , Zabojska Krystyna , Wojtas Aneta Klaudia , Cygnarowicz Aleksandra 
Published: January 2025

Introduction and purpose
Cachexia is a complex and multifactorial syndrome, which is a current, worldwide treatment challenge, and concerns most of the patients with cancer. The issue is characterized by anorexia, skeletal muscle loss, adipose tissue wasting, involuntary weight loss, malnutrition, and poor appetite due to dysfunction of metabolism and chronic, systemic inflammation. Additionally, it impacts oncological treatment and a decline in Quality of Life. The review aims to explore the latest research, innovations, and potentials in the treatment of cachexia.
Material and methods
The review was based on research of articles published from 2019 to 2024 on the PubMed database using the following keywords: cancer cachexia, palliative care, and cachexia pharmacotherapy.
Results
Anamorelin, a selective ghrelin receptor agonist showed effectiveness in weight gain and appetite improvement. Also, myostatin inhibitors protect muscles and promote their growth due to suppression of myostatin. Ponsegromab, a GDF-15 inhibitor, significantly and directly enhanced muscle mass, appetite, and quality of life, with good safety. Modern anti-inflammatory medications like momelotynib or tocilizumab, reduced the concentration of pro-inflammatory cytokines and improved quality of life, however, but posed immunosuppression risk. Pentoxifylline declined inflammation and chemotherapy toxicity, and improved body weight and survival. Cannabinoids alleviated chemotherapy-induced nausea but were ineffective for weight and quality of life.
Conclusions
Therapeutic approaches target various aspects of cachexia due to its complex pathophysiology. Anamorelin, ponsegromab, and myostatin inhibitors have clinical potential. Modern anti-inflammatory drugs and pentoxifylline offer supportive benefits. Further research is vital for developing effective and safe treatment guidelines for cancer cachexia.
Testing transient deviations from quantum mechanics’ predictions in spatially spread optical entangled states
Authors: Agüero M. , Hnilo A. , Kovalsky M. , Nonaka M. 
Published: January 2025

One of the conflicts between quantum mechanics (QM) and classical physics
is visible in the high correlation predicted by QM to exist between
observations performed on remote regions of a spatially spread entangled
state. It has been hypothesized that this correlation needs a time longer
than
L/c
to build up, where
L
is the spatial spread of the entangled state and
c
is the speed of light. In shorter times, the level of correlation would be
compatible with classical physics. This hypothesis is appealing, among
other reasons, as it solves that conflict by minimally modifying the
interpretation of QM. The hypothesis is difficult to test directly because
the observable difference would vanish fast, but a stroboscopic
observation is at hand. We present the results of such observation,
performed on a specially designed optical Bell setup with a distance
between stations up to
L=24m
in a straight line. This completes the preliminary results for short
L,
which we recently reported in this journal [J. Opt. Soc. Am. B
40, C28 (2023)JOBPDE0740-322410.1364/JOSAB.482398]. No
evidence of deviations from QM predictions is found. Yet, some additional
assumptions are involved; they are detailed and discussed. If fair
sampling is valid, then the hypothesis of transient deviations is refuted
unless the stroboscopic approach with a decay time shorter than
1.5 µs
(≈19L/c)
is false.
High-precision 1.5  µm band tunable single-frequency fluoro-sulfo-phosphate fiber laser based on a self-injection locking scheme
Authors: Geng Xin , Yang Changsheng , Wang Weichao , Zhang Qinyuan 
Published: January 2025

In this paper, a high-precision 1.5 µm band tunable single-frequency Er3+/Yb3+ co-doped fluoro-sulfo-phosphate (EYFSP) fiber laser based on a self-injection locking scheme is experimentally demonstrated. A self-developed 4 cm long EYFSP fiber with a high gain coefficient (3.2–4.7 dB/cm) at the C-band serves as the gain medium for laser output. The single longitudinal mode (SLM) operation is realized via a 15 cm long commercial unpumped gain fiber and a self-injection locking scheme, while flexible wavelength tuning is controlled by a fiber Fabry–Perot tunable filter (FFP-TF). The laser wavelength is tuned from 1528.08 to 1555.55 nm, with a tuning precision of up to 10–18 pm and a tuning speed of 30 nm/s. Throughout the entire tuning range of 27.47 nm, the measured laser linewidth is less than 1.3 kHz, the relative intensity noise remains below −140dB/Hz at frequencies above 3 MHz, and the power fluctuation is as low as 1% over a measurement period of 2 h. These results demonstrate that the high-precision 1.5 µm band tunable single-frequency EYFSP fiber laser is a promising candidate for future coherent optical communication systems and optical fiber sensing.
Ultralow-limit of detection optical fiber LSPR biosensor based on a ring laser for des-γ-carboxy prothrombin detection
Authors: Li Xiangshan , Singh Ragini , Zhang Bingyuan , Kumar Santosh , Li Guoru 
Published: January 2025

The ultralow limit of detection (LoD) and exceptional sensitivity of biosensors are a significant challenge currently faced in the field. To address this challenge, this work proposes a highly sensitive laser ring cavity biosensor capable of detecting low concentrations of des-
γ
-carboxy prothrombin (DCP). A tapered W-shaped fiber probe based on multi-mode fiber (MMF)-multi-core fiber (MCF)-MMF is developed to excite strong evanescent waves (EWs). By immobilizing gold nanorods (GNRs) on the fiber probe, localized surface plasmon resonance (LSPR) is generated at the near infrared wavelength to further enhance the sensitivity of the fiber probe. Moreover, an erbium-doped fiber (EDF) ring laser with a narrow full width at half maximum (FWHM) of 0.11 nm is employed as a light source. The spectrum with narrow FWHM has been demonstrated to obtain lower LoD. Compared to the ASE light source, the LoD of the laser ring cavity can be reduced by an order of magnitude. The developed biosensor is capable of detecting DCP within a concentration range of 0–1000 ng/mL, and the detection sensitivity of 0.265 nm/lg(ng/mL) and the LoD of 367.6 pg/mL are obtained. In addition, the proposed laser ring cavity biosensor demonstrates good specificity, reproducibility, and repeatability by corresponding tests. The study results indicate that the proposed biosensor has potential in the detection of hepatocellular carcinoma markers.
Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis
Authors: Muthanna Nader , Guan Xiaoyue , Alzahrani Fouad , Saif Badr Sultan , Seyam Abdelrahman , Alsalman Ahmed , Alajami Ahmed Es , Li Ang 
Published: January 2025

Introduction
Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evaluate the impact of regenerative procedures on the healing process following SRCT.

Methods
A comprehensive search of PubMed, Embase, Scopus, Cochrane, and the Web of Science found Randomized Controlled Trials (RCTs) published until February 25, 2024. Manual searches were also conducted. Our main outcome was SRCT success or failure after GTR procedures. The Risk Ratio (RR) and failure rate meta-analysis used a fixed effects model with a 95% confidence interval (CI). Subgroup analyses were conducted based on the use of different GTR procedures for varying lesion types in SRCT.

Results
Out of 1,605 records, 16 studies with 690 lesions were included. Overall, GTR procedures significantly improved healing after SRCT in both 2D (RR: 0.50; 95% CI, 0.34–0.73; P < 0.001) and 3D evaluation methods (RR: 0.36; 95% CI, 0.15–0.90; P < 0.001) with no significant difference between the two methods.

Conclusion
GTR significantly improved SRCT healing regardless of the evaluation method used. Combining collagen membranes with bovine bone-derived hydroxyapatite significantly enhanced the healing process. Additionally, GTR procedures significantly improve healing in through-and-through lesions.
The Scania Accelerated Intermittent Theta-burst Implementation Study (SATIS)–Lessons from an accelerated treatment protocol
Authors: Persson Marcus , Fabri Viktor , Reijbrandt Alexander , Lexén Annika , Eriksson Hans , Movahed Rad Pouya 
Published: January 2025

Background and objective
The Scania Accelerated Intermittent Theta-burst Implementation Study (SATIS) aimed to investigate the tolerability, preliminary effectiveness, and practical feasibility of an accelerated intermittent theta burst stimulation (aTBS) protocol in treating depression.

Methods
We used an open-label observational design, recruiting 20 patients (aged 19–84 years) from two public brain stimulation centers in Sweden. During the five-day treatment period and at a follow-up visit after 30 days we closely monitored adverse events and collected self-rated side effect data. Objective (MADRS, CGI) and subjective (MADRS-S) measures of symptoms and functioning (EQ-5D) were also assessed. Feasibility was evaluated using direct patient ratings combined with a qualitative approach evaluating staff experience.

Results
All patients reported adverse events at some point, the most common being headache (18/20 patients), but they were generally transient. MADRS scores decreased from 28.4 (min = 17, max = 38. SD = 6.9) at baseline to 20.0 (min = 1, max = 42. SD = 11.6) after the last day of treatment. 25% (n = 5) met the response criteria, with a mean time to response of 2.2 days (min = 1, max = 3. SD = 1.1). The practical arrangements surrounding this new treatment proved challenging for the organization, but patients reported few practical problems.

Conclusion
SATIS provided further insights into the potential benefits and challenges associated with aTBS protocols. Effectiveness and drop-out rates were comparable to national data of conventional iTBS, but with a markedly faster time to response. More resources were required than anticipated, increasing the clinical workload.
Association between composite dietary antioxidant indices and anemia: NHANES 2003–2018
Authors: Wu Qian , Wang Zhiyu , Xia Jieyu , Xu Hui , Huang Gang , Feng Guangyong , Gou Xiaoxia 
Published: January 2025

Background
There is increasing acknowledgment of the potential role that diet rich in antioxidants may play in the prevention of anemia. As a significant indicator of antioxidant-rich diet, the relationship between the composite dietary antioxidant index (CDAI) and anemia has not been extensively studied. Therefore, this study aims to explore the association between CDAI and anemia.

Methods
Utilizing datas from the 2003–2018 National Health and Nutrition Examination Survey (NHANES) database. The CDAI was calculated using six dietary antioxidants, based on two 24-hour dietary recall interviews, serving as comprehensive measure of the intake of these antioxidants. Weighted multivariable logistic regression and restricted cubic spline (RCS) analysis was conducted to investigate the association between CDAI and anemia. Furthermore, subgroup analyses were performed to enhance datas reliability.

Results
A total of 33914 participants were included in the study, among which 3,416 (10.07%) were diagnosed with anemia. The unadjusted model showed negative association between CDAI and anemia (odds ratio [OR]: 0.94; 95% confidence interval [95%CI]: 0.93–0.96; P < 0.001). After adjusting for all covariates, with each increase in CDAI level linked to 3% lower risk of anemia (OR: 0.97; 95%CI: 0.95–0.98; P < 0.001). Moreover, when CDAI was categorized into quartiles, the observed trend persisted (P < 0.001). The RCS analysis revealed linear negative relationship between CDAI and anemia (P for nonlinearity = 0.619). Except for sex, smoking, diabetes and hypertension, no statistically significant interactions were found in any subgroup analysis (P < 0.05 for interaction).

Conclusion
Our findings suggest that CDAI levels are inversely related to the prevalence of anemia. Consequently, monitoring individuals with low CDAI scores may facilitate the timely identification of anemia and enhance clinical decision-making.
Contribution of paranasal sinus, chest, and abdomen/pelvis computed tomography in patients with febrile neutropenia
Authors: Tran Charles , de Kerviler Éric , Bergeron Anne , Raffoux Emmanuel , Xhaard Aliénor , de Bazelaire Cédric , de Margerie-Mellon Constance 
Published: January 2025

Objective
Febrile neutropenia (FN) is a serious clinical event, associated with significant morbidity and mortality. Imaging has a central role in the identification of the fever cause. The study objectives were to assess abnormalities of potential infectious origin on paranasal sinus, chest and abdomen/pelvis CT scans performed during an episode of FN, in patients with or without specific clinical signs, and to evaluate their impact on the frequency of changes in treatment.

Materials and methods
This retrospective study included 306 patients with FN from a single academic center between October 2018 and December 2019. Clinical and biological data, final clinical diagnosis for the FN episode, and change in treatment following CT scans were collected from medical records. CT images were reviewed for positive findings in each anatomical region.

Results
Overall, 188 patients (61.4%) had at least one positive CT finding on paranasal sinus, chest and/or abdomen/pelvis regions, and 153 patients (50.0%) received a final clinical diagnosis of infection, based on microbiological and/or radiological findings. There were more chest and abdomen/pelvis CT positive findings in patients with specific clinical signs than in patients without (65.7% vs. 25.8%, and 59.0% vs. 22.7% respectively, p <0.001), with a higher frequency of therapeutic modifications in positive CTs. There were significantly more paranasal sinus CT abnormalities in symptomatic patients (33.3% vs. 8.5%, p = 0.03), but without any impact on treatment.

Conclusion
These results support recommendations to perform systematic chest CT in patients with FN and may encourage the widespread use of abdomen/pelvis CT in this indication, even without symptoms. However, the actual impact of their use on the prognosis of the patients remains to be evaluated.
2025 IGWS calendar
Authors: Wilkins Kristen , Sturgeon Polly 
Published: January 2025

The Indiana Geological and Water Survey's 2025 calendar focuses on geologists using mapping to help locate Indiana geohazards.
Landslides, earthquakes, karst, mine subsidence, and coastal erosion are all geologic hazards in Indiana. IGWS geologists are responding to these dangers by creating updated maps to support informed land-use decisions. Homeowners, educators, and emergency responders can use IGWS research to identify geologic hazards and mitigate their danger.
Learn about IGWS’s hazard research by visiting igws.indiana.edu/hazards.
Results of Czech gymnasium students in the TIMSS Advanced 1995 specialized physics test repeated in 2023
Authors: Pschotnerová Petra , Mandíková Dana , Chvál Martin 
Published: January 2025

The paper presents the first results of the TIMSS Advanced 1995 specialized physics test re-administered to final-year students of gymnasiums in the Czech Republic in 2023. In 2023, we used the original test booklets from 1995 in paper form. Of 90 gymnasiums from 1995, 72 participated in the repeated survey. Another 10 gymnasiums participated as replacement schools. In 1995, 819 students participated in the physics test. In the paper, we work with a sample of 1602 students from 2023. The overall mean achievement of students has decreased significantly compared to 1995. Males worsened more than females. Student mean achievement significantly lowered in all five physics content areas. The largest decrease in mean was observed in items from mechanics. More than a 10% decrease in the mean achievement most often appeared in items from the area of modern physics. In the case of open-ended items to which students had to create their own answers, the decrease in mean achievement was mainly due to the fact that students did not solve them at all. This may be due to the lower knowledge of the students caused by the reduction in the number of lessons devoted to teaching physics, but also to the lower motivation of the students when solving the test.