bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk of laryngitis with herpes zoster infection: A nested case-control study using data from the Korean National Sample Cohort
Authors: Joo Young-Hoon , Lee Hyun-Jin , Park Jun-Ook , Seo Young Joon , Kong Tae Hoon , Park Kyoung Ho 
Published: December 2021

Background
Whether herpes zoster infection (HZI) affects laryngitis incidence remains unknown.

Objective
The purpose of this population-based retrospective study was to analyze the relationship between laryngitis and HZI using data from the Korean Health Insurance Review and Assessment Service—National Sample Cohort.

Methods
This study analyzed 1,197,093 medical claim codes from 2018. Patients with HZI (ICD-10: B02) were retrospectively identified. Laryngeal diseases were defined by ICD-10 codes for five subgroups: 1) malignant disease, 2) benign disease, 3) vocal cord palsy, 4) inflammatory disease, and 5) reflux disease.

Results
Among the Korean population older than 20 years, 12,809 experienced HZI. Subjects with HZI were more likely to be older (mean age: 51.54 years vs. 48.06 years, p <0.0001). The proportion of subjects with laryngeal disease was higher in those with HZI than in those without HZI (55.55% vs. 41.37%, p <0.0001). Laryngeal disease was significantly associated with HZI in multiple regression analysis (odds ratio (OR) = 1.77, 95% confidence interval: 1.71–1.84) after adjusting for age, sex, hypertension, diabetes, dyslipidemia, ischemic heart disease, cerebral stroke, and depression. Among laryngeal disease subgroups, inflammatory disease (OR = 1.05; 95% CI: 1.01–1.09) and reflux (OR = 1.20; 95% CI: 1.15–1.25) were associated with HZI.

Conclusions
HZI is independently associated with laryngitis. Results of this study have implications for etiological investigations and prevention strategies for laryngitis.
Ángel ESTEBAN (ed.). Literatura latinoamericana y otras artes en el siglo XXI. Bruselas: Peter Lang, 2021
Authors: Cuevas Velasco Norma Angélica 
Published: December 2021

Reseña de Norma Cuevas sobre Literatura latinoamericana y otras artes en el siglo XXI. (Peter Lang, 2020) de Ángel Esteban (ed). 368 p. ISBN: 978-2-8076-1286-0. https://doi.org/10.3726/b17745
Desordem temporomandibular e ansiedade em graduandos de odontologia
Authors: Fernandes Aline Úrsula Rocha , Garcia Alício Rosalino , Zuim Paulo Renato Junqueira , Cunha Lígia Del’Arco Pignatta , Marchiori André Vinícius 
Published: December 2021

As Desordens Temporomandibulares são doenças que afetam as articulações temporomandibulares e músculos da mastigação do aparelho estomatognático. Fatores psicossociais desempenham papel importante na etiopatogenia dessa doença. O objetivo deste estudo é avaliar a relação entre o grau de desordem temporomandibular e o nível de ansiedade em estudantes de graduação em Odontologia, em três períodos do curso (1o ao 4o semestres, 5o ao 7o, e 8o ao 10o semestres), por meio dos questionários auto-aplicáveis Índice Anamnésico de Fonseca e do Inventário de Ansiedade Traço-Estado (IDATE). Os dados foram tabulados e posteriormente analisados por meio dos testes estatísticos Kruskal-Wallis e correlação de Pearson, ao nível de significância de 1%. Os resultados mostraram correlação positiva e diferença estatisticamente significante entre DTM e ansiedade, em todos os períodos avaliados; e um nível mais alto de ansiedade foi observado no período intermediário do curso (5o ao 7o semestres). Concluímos que houve relação diretamente proporcional entre DTM e ansiedade nos alunos avaliados, estatisticamente significante, independente do estágio cursado; o maior nível de ansiedade foi observado no grupo formado por alunos do 5o ao 7o semestres, contudo sem nenhuma significância estatística. Torna-se importante desenvolver uma estratégia para o controle do estresse e da ansiedade dos alunos no curso de graduação em Odontologia.
Influência do tempo de aplicação de um gel clareador a base de peróxido de carbamida a 10% na cor dos dentes - um estudo in vitro
Authors: Cardoso Paula de Carvalho , Godoy Fabrício da Silva , Oliveira Marcelo Tomás de , Baratieri Luiz Narciso 
Published: December 2021

Este trabalho teve como objetivo avaliar, in vitro, influência do tempo de aplicação do peróxido de carbamida à 10% no resultado da cor dos dentes, através do espectrofotômetro. Trinta pré-molares extraídos foram envolvidos neste estudo, divididos aleatoriamente em 3 grupos. O tempo de aplicação diário do agente clareador variou em: GI- 1h; GII- 2h e GIII- 8h. O clareamento dental foi realizado com peróxido de carbamida a 10% (WHITENESS STANDARD 10%, FGM Produtos Odontológicos, Joinville - SC - Brasil) durante 15 dias. A determinação da cor dos espécimes foi realizada antes e após o tratamento clareador através espectrofotômetro (VITA Easyshade 2, Vident, Brea, CA, USA). Após o teste ANOVA, observou-se que não houve diferença estatística para a variável tempo de aplicação nas coordenadas L*, a*, b* e ?E, com valor de p igual: 0,439; 0,089; 0,752 e 0,065, respectivamente. Em relação ao período, observou-se que os valores de L* aumentaram (p= 0,0124) e os de b* diminuíram (p= 0,000).Concluiu-se que o tempo de aplicação de 8h deve ser substituído pelo de 1h ou 2h, pela similaridade na mudança de cor dos 3 grupos.
Estudo comparativo dos métodos de avaliação do desajuste vertical na interface pilar/implante
Authors: Barbosa Gustavo Augusto Seabra , Bernardes Sérgio Rocha , Mattos Maria da Glória Chiarello de , Neto Alfredo Júlio Fernandes , Neves Flávio Domingues das , Ribeiro Ricardo Faria 
Published: December 2021

Alguns trabalhos avaliam o desajuste vertical na interface pilar/implante por meio do teste do parafuso único, enquanto outros aplicam torque nos parafusos antes da avaliação. Este trabalho objetiva avaliar se estas duas metodologias geram diferentes interpretações dos resultados quanto ao nível de ajuste vertical das infra-estruturas. Com a utilização de pilares do tipo UCLA calcináveis (Neodent, Brasil), quatro infra-estruturas de cinco elementos foram confeccionadas sobre modelo de gesso obtido a partir de matriz metálica contendo cinco implantes do sistema Brånemark (3,75X9mm, Neodent, Brasil) e em seguida foram fundidas em monobloco em titânio comercialmente puro (grau I, Talladium, Brasil). Por meio de microscópio óptico comparador (Mytutoyo, Japão) sob aumento de 30x, avaliou-se o desajuste vertical na interface pilar/implante de cada pilar da infra-estrutura, inicialmente pelo teste do parafuso único e posteriormente ao aperto de todos os parafusos, com torque de 20Ncm obtido por meio de torquímetro manual (Neodent, Brasil). A partir do modelo de gesso, confeccionou-se modelo fotoelástico para avaliação de possíveis tensões geradas após os apertos dos parafusos. Submeteu-se os resultados à análise estatística (P<0,05). O teste t mostrou diferença estatisticamente significante (P=0,000) entre o desajuste no lado desapertado verificado após o teste do parafuso único (472,49±109,88μm) e após o aperto de todos os parafusos (29,09±13,24μm). A fotoelasticidade mostrou grande quantidade de tensão gerada ao redor dos implantes após o aperto dos parafusos (11,38±8,27KPa). Conclui-se que a metodologia utilizada na verificação dos desajustes verticais pode gerar diferentes interpretações quanto ao nível de desajuste vertical de infraestruturas para próteses sobre implantes.
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis
Authors: Mirzaee Shahla , Golestannejad Zahra , Sadeghian Rastin , Rohani Bita , Sadeghian Saeid 
Published: December 2021

Objective: Recurrent aphthous stomatitis (RAS) is characterized by recurring ulcers, with well-defined margins. The lesions are confined to the oral mucosa (usually seen in non-keratinized mucosa). The disease manifests in the form of outbreaks, with a chronic and self-limiting course in most cases. Since the cause of the disease is unknown, many drugs have been studied to palliate the symptoms. Treatment used is multifocal and varies according to the predisposing factors. The aim of this study was to investigate the effect of recombinant Nano-based triamcinolone acetonide gel and compare it with conventional triamcinolone gel on RAS. Material and methods: In this triple-blind randomized clinical trial study, sixty patients with minor aphthous lesions were divided into two groups receiving conventional triamcinolone (CT) and Nano-based triamcinolone (NT). The patients were requested to apply drug four times a day for a week. The severity of pain (through VAS) and the size of the lesions (mean of the largest diameter of the lesions) were evaluated on starting day and days 2, 4, 6 after the intervention. Statistical analysis was performed using chi square and independent t-test. Findings were significant with P < 0.05. Findings: Of the 60 patients enrolled in the study, 5 patients did not continue; 21 (38.2%) cases were female and 34 (61.8%) cases were male (P=0.6). The severity of pain in NT group before and after the study was 1.4 ± 5.2 and 1.8 ± 1.3 cm, respectively and in CT group was 48.1 ± 1 and 1.8 ± 1.3 cm. The size of the lesions in NT group before and at the end of the study was 0.96 ± 0.1 and 0.18 ± 0.1 cm, respectively and in CT group was 0.93 ± 0.1 and 0.19 ± 0.1 cm. Among the mentioned variables, only size of lesions on the 2nd and 4th days had a significant reduction in NT group in comparison with CT group. Conclusion: The size of lesions showed a significant reduction on the 2nd and 4th days in NT group in comparison with CT group, therefore NT has a better impact on RAS in comparison with CT.KEYWORDSNanoparticle; Recurrent aphthous stomatitis; Treatment; Triamcinolone.
By an anniversary of the birth of Johann Peter Müller — 220 years
Authors: Buyvalenko U. V. , Levshina A. R. 
Published: December 2021

July 14, 2021 marks the 220th anniversary of an outstanding scientist and physician — Johann Peter Müller. It is thanks to his works that we know what the «endocrine gland» is, understand the taxonomy of the animal world and the essence of ontogenesis. Professor, researcher, wonderful teacher, director of the anatomical and physiological museum of the University of Berlin — he succeeded in any role in life. Mueller’s discoveries were recognized during his lifetime, textbooks were published under his leadership, and scientific articles were published. The value of the professor’s work is high to this day, which once again proves the colossal contribution of Johann Müller in the formation of world science.
Simulation and Experimental Investigation of a Hollow, Bipolar Needle Electrode
Authors: Liu Jan , Hauser Lina , Kappel Marcel , Göhring Chris , Pott Peter P. 
Published: December 2021

Abstract
Localized impedance measurements at the needle tip identifying the present tissue type could aid clinicians in needle procedures. To assess the sensitivity field of a hollow, bipolar needle electrode, a 3D finite element approach using COMSOL Multiphysics was chosen. The simulated bipolar needle electrode consists of two hypodermic needles (17 G and 23 G) with an insulating layer of polytetrafluoroethylene (PTFE) in between. Impedance values were recorded while steadily increasing the insertion depth of the needle electrode in a layered tissue structure of skin (dermis), fat, and blood. Simulation results reveal a highly local sensitivity volume around the needle tip that can be approximated by half a tri-axial ellipsoid with elliptic radii of 0.735 mm, 2.886 mm, and 1.774 mm. A comparison with simulated and measured impedance values shows great correspondence.
Automated Robust Interpretation of Intraoperative Electrophysiological Signals – A Bayesian Deep Learning Approach
Authors: Kortus Tobias , Krüger Thilo , Gühring Gabriele , Lente Kornelius 
Published: December 2021

Abstract
Intraoperative neurophysiological monitoring (IONM) is an essential tool during numerous surgical interventions to assess and monitor the functional integrity of neural structures at risk. A reliable signal interpretation is of importance to support medical staff by reducing manual evaluation. Deep learning (DL) techniques proved to be a robust tool for the analysis of neurophysiological data. The large amount of required manually labeled data as well as the lack of interpretability of the results however often limit the use of DL in medical scenarios. A possible way to tackle these obstacles is the utilization of Bayesian deep learning (BDL) methods. The modelling of uncertainties in the network parameters and the thereby possible quantification of predictive uncertainties allows both the identification of potential erroneous predictions as well as the targeted selection of informative signals in the context of active learning. To evaluate the applicability of BDL for the analysis of electrophysiological data as well as to increase the training efficiency by active learning, we implemented a multi-task Bayesian Convolutional Neural Network (BCNN) for the simultaneous classification of action potentials and the assessment of relevant signal characteristics (latency, maximum, minimum). We compare the results for electromyographical signals (EMG), containing in total approximately twelve thousand signals from 34 patients, with both a traditional non-Bayesian single-task and multi-task CNN. For all models, including the BCNN, we could achieve similar performances with detection rates over 97% accuracy. Further, we could improve training efficiency of the BCNN using pool-based active learning and therefore significantly reduce the required amount of manual labeling. The evaluated predictive uncertainties of the BCNN prove useful both for the efficient selection of informative signals in the context of active learning as well as the interpretation of the predictive posterior distribution and therefore trustworthiness of the classifications.
A method to determine the accuracy of shape setting thin, spirally shaped Nitinol wires
Authors: Ehmann Tim , Zuniga M. Geraldine , Lenarz Thomas , Rau Thomas S. 
Published: December 2021

Abstract
Electric stimulation of the auditory nerve using a cochlear implant (CI) is presumed to be superior when the electrode array (EA) is placed close to the inner wall of the cochlea. Nitinol is investigated as an actuator that enables an intracochlear shape change of the EA from a straight configuration (also necessary for the insertion) to a spiral shape fitting to the inner wall. As shape setting of the thin Nitinol wires is crucial, a method to quantify the accuracy of the shape setting is presented. To measure the trained shape of thin Nitinol wires (ø 100 μm) a contactless, optical method was developed. For each wire, a photomicrograph was captured and processed using a custom Matlab algorithm. Threshold based segmentation followed by morphological operations to remove artefacts were applied to extract the wire’s shape. Utilizing an iterative closest point (ICP) algorithm the actual shape was registered to the desired spiral path. Finally, the root mean squared error describing the deviation between both spirals was calculated as a measure for the “shape error” (εshape). In total 147 Nitinol wires of 16 batches were analyzed to quantify the reliability of the shape setting procedure. The proposed method was successfully applied in all samples. On average εshape was 0.06 ± 0.02 mm. Deviation from the desired shape was < 0.1 mm (< 0.15 mm) in 95% (99%) of the samples. In summary, the presented method is suitable to control the trained shape of thin Nitinol wires. Furthermore, our results confirm a high reliability of the shape setting procedure used for our thin Nitinol actuators intended for future applications in CI EAs.
Impact of statins on vascular scaffolds response in porcine carotid arteries
Authors: Kischkel Sabine , Grabow Niels , Bünger Carsten M. , Püschel Anja 
Published: December 2021

Abstract
Surgical treatments of arterial occlusive disease with fully absorbable polymeric scaffolds, as a potential alternative to permanent metallic stents, are increasingly penetrating the clinical field. An addition part of the management of patients suffering from vascular diseases is the administration of statins. In this study, absorbable x-ray marked PLLA-based polymer scaffolds and permanent bare-metal stents (BMS) were implanted interventionally into both common carotid arteries (CCA) of 6 healthy female pigs via the left common iliac artery (8F-sheath). The pigs were administered dual antiplatelet drugs oral starting 3 days before the procedure until the end of the study. In Addition, the pigs received atorvastatin orally, beginning 5 days prior to surgery and lasting until the study ended. Stented CCA segments were explanted after 4 weeks, and processed for quantitative histomorphometry, and estimation of vascular inflammation and injury scores. Polymer scaffolds showed a decreased residual lumen area and higher stenosis after 4 weeks (6.41 ± 0.83 mm² and 40.52 ± 5.01%) as compared to the bare-metal reference stent (15.17 ± 0.896 mm² and 7.80 ± 0.88%). After 4 weeks, inflammation score were higher in the polymer group (1.30 ± 0.37) compared to the BMS group (0.42 ± 0.18). In contrast, the BMS showed a slightly elevated vascular injury score (0.85 ± 0.12), as compared to the polymer (0.60 ± 0.23) group. In this preclinical model, the new absorbable polymeric scaffolds showed similar technical feasibility and safety for vascular application as the permanent metal stents. Although no positive trends were observed with oral treatment with atorvastatin, further optimization with a dual-loaded coating is still reasonable. In addition, reduced strut thickness of the polymer scaffolds would have potential to positively impact tissue ingrowth between struts and should be considered in future work on stent design.
Comb filters for the removal of transcranial current stimulation artifacts from single channel EEG recordings
Authors: Guggenberger Robert , Gharabaghi Alireza 
Published: December 2021

Abstract
The combination of transcranial alternating current stimulation (tACS) and electroencephalogram (EEG) for mobile and home-based interventions offers the potential for control and adaptation of stimulation parameters. Yet, during stimulation, the EEG is heavily affected by stimulation artifacts. Spatial filters are often unsuited because too few channels are recorded and hardware capabilities are limited. Due to their speed and as they can be used for single channels, we explore the performance of single-channel weighted comb filters on artifact removal. At any given time point t, the recording r(t) is a superposition of a neurophysiological signal n(t), the stimulation artifact a(t) and noise e(t). Now, we can estimate the artifact a(t) based on the recording from an earlier (or later) time-point shifted by the artifacts period. A weighted estimate based on multiple time points has the potential to improve the signal recovery. Therefore, we explored several approaches and evaluated their performance on simulated and real data. The comb kernel filters were implemented in Matlab (https://github.com/agricolab/ARtACS) and Python (https://github.com/agricolab/pyARtACS), and the code is open access under an X11-license. We found that independent of the weighting function, all comb filters exhibit similarity in their suppression of the DC component, the artifacts frequency, and its harmonics. Yet, different weighting functions exhibit different pass-band performance, evident as ringing and amplification, and their induction of time-domain echoes. Interestingly, we note that a causal uniform filter is comparable to more complex approaches, while offering the option for real-time filtering. Comb filters are able to remove tACS artifacts even if only a single channel is available. As comb filters require no assumptions about the shape of the artifact, they might also be useful for filtering of non-sinusoidal, e.g. pulsed or saw-tooth, transcranial current stimulation.
Persistent homology approach distinguishes potential pattern between “Early” and “Not Early” hepatic decompensation groups using MRI modalities
Authors: Singh Yashbir , Jons William , Conte Gian Marco , Jagtap Jaidip , Zhang Kuan , Sobek Joseph D. , Rouzrokh Pouria , Eaton John E. , Erickson Bradley J. 
Published: December 2021

Abstract
Primary sclerosis cholangitis (PSC) predisposes individuals to liver failure, but it is challenging for radiologists examining radiologic images to predict which patients with PSC will ultimately develop liver failure. Motivated by algebraic topology, a topological data analysis - inspired framework was adopted in the study of the imaging pattern between the “Early Decompensation” and “Not Early” groups. The results demonstrate that the proposed methodology discriminates “Early Decompensation” and “Not Early” groups. Our study is the first attempt to provide a topological representation-based method into early hepatic decompensation and not early groups.
Development of a mobile, cost-effective and easy to use inertial motion capture system for monitoring in rehabilitation applications
Authors: Schlage Nana , Kitzig Andreas , Stockmanns Gudrun , Naroska Edwin 
Published: December 2021

Abstract
Many people are familiar with the feeling of instability, pain, or subsidence in the knee joint after a knee injury. There are many different methods for examining the knee, such as the drawer test or the Lachman test [1], before and after surgery. While these tests can be used in short term and provide useful results, motion capture systems can be used as an alternative measurement method, almost as a substitute in longer term. These include marker-based or mechanica l systems, which achieve good measurement results but are expensive and inflexible. For this reason, this paper presents a mobile, easy-to-use motion and easy expandable capture system using a low-cost IMU-based development system. The modular design of the system allows it to be adapted to each body region with simple adjustments. However, the present work focuses on applications for capturing human motion sequences and deriving three joint angles of the lower extremities to detect malposition.