bluuebunny/crossref_metadata_2025_split huggingface dataset:
6-Gingerol Alleviates Neonatal Hypoxic-Ischemic Cerebral and White Matter Injury and Contributes to Functional Recovery
Authors: Zhao Man , Yao Yuan , Du Jingyi , Kong Liang , Zhao Tiantian , Wu Dong , Man Lajie , Zhou Wenjuan 
Published: September 2021

Hypoxic-ischemic encephalopathy (HIE) is one main cause of neonatal death and disability, causing substantial injury to white and gray matter, which can lead to severe neurobehavioral dysfunction, including intellectual disability and dyskinesia. Inflammation, nerve cell death, and white matter injury are important factors in the pathological process of HIE. 6-Gingerol is a ginger extract, which reduces inflammatory response and cell death. However, the role of 6-Gingerol in neonatal hypoxic-ischemic brain injury (HIBI) remains unknown. In this study, we constructed a mouse HIBI model and analyzed the protective effect of 6-Gingerol on HIBI by using behavioral tests, histological staining, qPCR and western blot. Here, we found that 6-Gingerol treatment could alleviate HIBI and improve short-term reflex performance, which is closely related to cell death and neuroinflammation. Additionally, 6-Gingerol reduced neuronal apoptosis, pro-inflammatory factor release, as well as microglial activation. Furthermore, 6-Gingerol significantly improved motor disability, which is associated with white matter damage. Thus, our results showed that 6-Gingerol could reduce the loss of myelin sheaths, alleviate cell death of oligodendrocytes, and stimulate the maturation of oligodendrocytes. In terms of mechanism, we found that 6-Gingerol decreased histone H3K27me3 levels, activated AKT pathway and inhibited the activation of ERK and NF-κB pathway at 3 days post-HIBI. Taken together, our data clearly indicate that 6-Gingerol plays a neuroprotective role against HIBI by epigenetic modification and regulation of AKT, ERK, and NF-κB pathways, inhibiting inflammatory responses and reducing cell death.
Neonatal Feeding Trajectories in Mothers With Bipolar Disorder Taking Lithium: Pharmacokinetic Data
Authors: Imaz Maria Luisa , Langohr Klaus , Torra Mercè , Soy Dolors , García-Esteve Luisa , Martin-Santos Rocio 
Published: September 2021

Purpose: Women who take lithium during pregnancy and continue after delivery may choose to breastfeed, formula feed, or mix these options. The aim of the study was to evaluate the neonatal lithium serum concentrations based on these three feeding trajectories.Methods: We followed 24 women with bipolar disorder treated with lithium monotherapy during late pregnancy and postpartum (8 per trajectory). Lithium serum concentrations were determined by an AVL 9180 electrolyte analyser with a 0.10 mEq/L detection limit and a 0.20 mEq/L limit of quantification (LoQ).Results: There was complete lithium placental passage at delivery, with a mean ratio of lithium concentration in the umbilical cord to maternal serum of 1.12 ± 0.17. The median times to LoQ were 6–8, 7–8, and 53–60 days for formula, mixed, and exclusive breastfeeding respectively. The generalized log-rank testing indicated that the median times to LoQ differ according to feeding trajectory (p = 0.037). According to the multivariate analysis-adjusted lithium serum concentrations at birth, times to LoQ are, on average, longer under exclusive breastfeeding (formula, p = 0.015; mixed, p = 0.012). No lithium accumulation was observed in infants under either exclusive or mixed breastfeeding. During the lactation follow-up, there was no acute growth or developmental delays in any neonate or infant. Indeed, lithium concentrations in the three trajectories declined in all cases. However, the time needed to reach the LoQ was much longer for those breastfeeding exclusively.Conclusions: In breastfeed infant no sustained accumulation of lithium and no adverse effects on development or growth were observed.
Transcriptomics Analysis Reveals Shared Pathways in Peripheral Blood Mononuclear Cells and Brain Tissues of Patients With Schizophrenia
Authors: Song Xuemian , Liu Yiyun , Pu Juncai , Gui Siwen , Zhong Xiaogang , Chen Xiaopeng , Chen Weiyi , Chen Xiang , Chen Yue , Wang Haiyang , Cheng Ke , Zhao Libo , Xie Peng 
Published: September 2021

Background: Schizophrenia is a serious mental disorder with complicated biological mechanisms. Few studies explore the transcriptional features that are shared in brain tissue and peripheral blood. In the present study, we aimed to explore the biological pathways with similar expression patterns in both peripheral blood mononuclear cells (PBMCs) and brain tissues.Methods: The present study used transcriptomics technology to detect mRNA expression of PBMCs of 10 drug-naïve patients with schizophrenia and 20 healthy controls. Transcriptome data sets of brain tissue of patients with schizophrenia downloaded from public databases were also analyzed in our study. The biological pathways with similar expression patterns in the PBMCs and brain tissues were uncovered by differential expression analysis, weighted gene co-expression network analysis (WGCNA), and pathway analysis. Finally, the expression levels of differential expressed genes (DEGs) were validated by real-time fluorescence quantitative polymerase chain reaction (qPCR) in another 12 drug-naïve patients with schizophrenia and 12 healthy controls.Results: We identified 542 DEGs, 51 DEGs, 732 DEGs, and 104 DEGs in PBMCs, dorsolateral prefrontal cortex, anterior cingulate gyrus, and nucleus accumbent, respectively. Five DEG clusters were recognized as having similar gene expression patterns in PBMCs and brain tissues by WGCNA. The pathway analysis illustrates that these DEG clusters are mainly enriched in several biological pathways that are related to phospholipid metabolism, ribosome signal transduction, and mitochondrial oxidative phosphorylation. The differential significance of PLAAT3, PLAAT4, PLD2, RPS29, RPL30, COX7C, COX7A2, NDUFAF2, and ATP5ME were confirmed by qPCR.Conclusions: This study finds that the pathways associated with phospholipid metabolism, ribosome signal transduction, and energy metabolism have similar expression patterns in PBMCs and brain tissues of patients with schizophrenia. Our results supply a novel insight for revealing the pathogenesis of schizophrenia and might offer a new approach to explore potential biological markers of peripheral blood in schizophrenia.
The Prevalence of Depressive and Insomnia Symptoms, and Their Association With Quality of Life Among Older Adults in Rural Areas in China
Authors: Yang Juan-Juan , Cai Hong , Xia Lei , Nie Weicheng , Zhang Yulong , Wang Song , Shi Yudong , Ng Chee H. , Liu Huanzhong , Xiang Yu-Tao 
Published: September 2021

Background:There are few studies on the epidemiology of depression, insomnia, and their association with quality of life (QOL) in older adults living in rural China. This study examined the prevalence of depressive and insomnia symptoms, and their association with QOL in community-dwelling older adults in a rural area in Anhui province, China.Methods:This was a cross-sectional study conducted in the rural areas of four cities (Hefei, Huaibei, Anqing, and Xuancheng) in Anhui province between July and October, 2019 using random sampling method. All community-dwelling residents from the selected villages who met the study entry criteria were invited to participate in this study. Depressive and insomnia symptoms and QOL were assessed with the Chinese version of self-reported Center for Epidemiological Survey Depression Scale (CES-D), the Insomnia Severity Index (ISI) and the 26-item World Health Organization Quality of Life Brief version (WHOQOL-BREF), respectively.Results:A total of 871 older adults were included. The prevalence of overall depressive symptoms, insomnia symptoms, and comorbid depressive and insomnia symptoms were 34.0% [95% confidence intervals (95% CI): 30.8–37.1%], 45.7% (95% CI: 42.4–49.0%) and 20.3% (95% CI: 17.6–23.0%), respectively. Older adults with depressive symptoms, insomnia symptoms, and comorbid depressive and insomnia symptoms had lower scores in QOL compared to those without. Depressive symptoms were positively associated with living with families [Odd Ratio (OR) = 1.82, 95% CI: 1.31–2.54] and negatively associated with current drinking (OR = 0.49, 95% CI: 0.33–0.72). Insomnia symptoms were negatively associated with fair and good financial status (fair: OR = 0.53, 95% CI = 0.38–0.75; good: OR = 0.30, 95% CI = 0.14–0.64) and current drinking (OR = 0.64, 95% CI = 0.45–0.93), and positively associated with more frequent major medical conditions (OR = 1.32, 95% CI = 1.16–1.51). Comorbid depressive and insomnia symptoms were positively associated with living with families (OR = 2.02, 95% CI = 1.36–3.00), and negatively associated with fair and good financial status (fair: OR = 0.61, 95% CI = 0.41–0.89; good: OR = 0.34, 95% CI = 0.12–0.95) and current drinking (OR = 0.57, 95% CI = 0.35–0.92).Conclusion:Depressive and insomnia symptoms were common in older adults living in rural areas in China. Considering the negative health outcomes caused by depressive and insomnia symptoms, regular screening and effective treatments should be developed for this population.
Case Report: Whole-Exome Sequencing of Hypothalamic Hamartoma From an Infant With Pallister-Hall Syndrome Revealed Novel de novo Mutation in the GLI3
Authors: Yang Yue , Shen Fang , Jing Xie-Pan , Zhang Nu , Xu Shang-Yu , Li Dan-Dong , Zhou Ling-Li , Bai Guang-Hui , Fang Huang-Yi , Zhang Zhong-Ding , Pang Chen , Lin Jian , Sheng Han-Song 
Published: September 2021

Background:GLI-Kruppel family member 3 (GLI3), a zinc finger transcription factor of the sonic hedgehog pathway, is essential for organ development. Mutations inGLI3cause several congenital conditions, including Pallister-Hall syndrome (PHS), which is characterized by polydactyly and hypothalamic hamartoma. Most patients are diagnosed soon after birth, and surgical removal of hypothalamic hamartoma in the very young is rarely performed because of associated risks.Case presentation:A 7-month-old boy with PHS features, including a suprasellar lesion, bifid epiglottis, tracheal diverticulum, laryngomalacia, left-handed polydactyly and syndactyly, and omental hernia was referred to our service. His suprasellar lesion was partially removed, and whole-exome sequencing was applied to the resected tumor, his peripheral blood, and blood from his parents. Histopathology confirmed the diagnosis of hypothalamic hamartoma, and molecular profiling revealed a likely pathogenicde novovariant, c.2331C&gt;G (p. H777Q), inGLI3. Magnetic resonance imaging follow-up 1 year later showed some residual tumor, and the patient experienced normal development post operation.Conclusions:We presented a case of PHS that carries a novelGLI3variant. Hypothalamic hamartoma showed a distinct genetic landscape from germline DNA. These data offer insights into the underlying etiology of hypothalamic hamartoma development in patients with PHS.
Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
Authors: Smith Joe S. , Mochel Jonathan P. , Soto-Gonzalez Windy M. , Rahn Rebecca R. , Fayne Bryanna N. , Escher Olivia G. , Geletka Anastasia M. , Harvill Lainey E. , Bergman Joan B. , Cox Sherry 
Published: September 2021

Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats.Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats.Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole and pantoprazole sulfone concentrations. Pharmacokinetic parameters were determined by non-compartmental analysis.Results: Plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 0.345 mL/kg/min, 0.7 h, and 0.9 L/kg, respectively following IV administration. The maximum concentration, elimination half-life and area under the curve of pantoprazole sulfone were estimated at 0.1 μg/mL, 0.8 h, and 0.2 hr*μg/mL, respectively. The global extraction ratio was estimated 0.00795 ± 0.00138. All animals had normal physical examinations after conclusion of the study.Conclusion: The reported plasma clearance for pantoprazole is lower than reported for foals, calves, and alpacas. The elimination half-life appears to be &lt; that reported for foals and calves. Future pharmacodynamic studies are necessary for determination of the efficacy of pantoprazole on acid suppression in goats.
A Neural Network Approach towards Generalized Resistive Switching Modelling
Authors: Carvalho Guilherme , Pereira Maria , Kiazadeh Asal , Tavares Vítor Grade 
Published: September 2021

Resistive switching behaviour has been demonstrated to be a common characteristic to many materials. In this regard, research teams to date have produced a plethora of different devices exhibiting diverse behaviour, but when system design is considered, finding a ‘one-model-fits-all’ solution can be quite difficult, or even impossible. However, it is in the interest of the community to achieve more general modelling tools for design that allows a quick model update as devices evolve. Laying the grounds with such a principle, this paper presents an artificial neural network learning approach to resistive switching modelling. The efficacy of the method is demonstrated firstly with two simulated devices and secondly with a 4 μm2 amorphous IGZO device. For the amorphous IGZO device, a normalized root-mean-squared error (NRMSE) of 5.66 × 10−3 is achieved with a [2, 50,50 ,1] network structure, representing a good balance between model complexity and accuracy. A brief study on the number of hidden layers and neurons and its effect on network performance is also conducted with the best NRMSE reported at 4.63 × 10−3. The low error rate achieved in both simulated and real-world devices is a good indicator that the presented approach is flexible and can suit multiple device types.
Rendimiento del trigo cv. ‘centenario’ bajo diferentes densidades de siembra en un sistema de riego presurizado
Authors: Solis Rosas Diaz Luis Felipe , Tejada Soraluz Jorge , Jiménez Dávalo Jorge 
Published: September 2021

El experimento se llevó a cabo en la provincia y departamento de Ica, Perú (costa central) bajo un sistema de riego presurizado, en el cultivo de trigo (Triticum aestivum ssp. aestivum) cv. ‘centenario’, en la cual hay mucha área bajo riego con agua de alta salinidad, el trigo por su resistencia a la alta salinidad del agua es una alternativa viable. Se utilizó el Diseño de Bloques Completamente al Azar con arreglo factorial, con 9 tratamientos y 4 repeticiones. Aplicando 2 factores, distanciamiento entre semillas (S) S0.5 cm, S1.0 cm y S2.0 cm y número de líneas (L) L2, L4 y L6. Para la comparación de medias se utilizó la prueba Duncan al 0.05 de significancia. En todas las variables en el análisis de varianza no se obtuvo significancia en la interacción entre los factores S y L. En rendimiento por ha-1 con el distanciamiento entre semillas a 1.0 cm y 2.0 cm (S1 y S2) se obtuvo 11513.89 y 11044.44 kg por ha-1 respectivamente y con cuatro líneas de trigo (L4) se obtuvo 12343.75. El mayor número de espigas por m-2 se obtuvo al sembrar entre semillas con 0.5 cm y 1.0 cm con 681.42 y 653.33 espigas por m-2. Con 4 y 6 líneas se obtuvo 727.67 y 693.50 espigas por m-2. Para obtener los mejores rendimientos y economizar semillas se debe emplear los factores S2 y L4. El mayor número de espigas por m-2 se obtuvo con los factores S0.5, S1.0, L4 y L6.
Suplementación de cromo sobre concentraciones séricas de glucosa, cortisol e insulina en equinos deportistas
Authors: Pazmiño Galarza Fernando , Romero Celleri Lenin , Grijalva Olmedo Jorge , Aragón Vázquez Eduardo 
Published: September 2021

El objetivo del estudio fue determinar como la suplementación de cromo afecta el rendimiento de caballos deportivos, se evaluó los posibles efectos de dos fuentes de suplementos de cromo orgánico en caballos atléticos. Se evaluaron 15 equinos deportivos, raza Argentina Saddle, de 12 a 15 años, alimentados con concentrado, pasto de centeno y heno de alfalfa. Fueron divididos en tres grupos experimentales:i) el grupo de control recibió dieta basal sin suplementación, ii) dieta basal suplementada con 20 mg de cromo en forma de levadura enriquecida por 30 días; y iii) dieta basal suplementada con 20 mg de cromo en forma de tripicolinato de cromo por 30 días. Después, se realizó una prueba submáxima de esfuerzo y posterior una evaluación de niveles sanguíneos de glucosa, cortisol e insulina. El análisis estadístico del nivel de glucosa no mostró diferencias significativas para ninguno de los tratamientos (P> 0.05), pre y post ejercicio. El cortisol plasmático fue similar entre el tratamiento pre-ejercicio, la levadura enriquecida con cromo y el cromo orgánico, disminuyeron el nivel de cortisol en sangre post ejercicio (P <0,05). La concentración plasmática de insulina se vio influenciada por la suplementación con cromo después del ejercicio intensivo, los resultados demostraron que el nivel de insulina en sangre fue mayor en los caballos que no recibieron suplementación (P <0.01) en comparación con los grupos que recibieron suplementación de cromo. La suplementación con cromo orgánico en caballos deportivos no modificó la glucosa plasmática, pero si la concentración sanguínea de cortisol e insulina.
METHODOLOGY FOR ANALYSIS OF PHYSICAL AND CHEMICAL PROPERTIES AND COMPOSITION OF OIL, GAS, CONDENSATE AND WATER AT THE KARACHAGANAK DEPOSIT
Authors: Гребнев П.С. , Вдовин Д.Ю. , Миксонов М.Г. , Цуров М.Б. 
Published: September 2021

В статье рассматривается методология анализа физико-химических свойств и состава нефти, газа, конденсата и воды, а также применяемые методы увеличения нефтеотдачи, такие как тепловые, газовые и физические. Представлен отбор и PVT-исследования проб пластового флюида.
The article discusses the methodology for analyzing the physical and chemical properties and composition of oil, gas, condensate and water, as well as the applied methods of enhanced oil recovery, such as thermal, gas and physical. The selection and PVT-studies of reservoir fluid samples are presented.
STUDY OF PROPERTIES OF CELLULAR CONCRETE BASED ON MIXED BINDER
Authors: Каршыга Г.О. , Сарсенбаев Н.Б. , Каршыгаев Р.О. , Сауганова Г.Р. , Ауесбек С.Т. 
Published: September 2021

Разработка смешанных вяжущих, комплексных порообразователей и технологии производства неавтоклавных ячеистых бетонов на их основе является актуальным в плане поиска путей повышения эксплуатационных свойств и технологичности производства указанного материала. Целью данной работы является разработка составов сухой строительной смеси для неавтоклавных ячеистых бетонов.
The development of mixed binders, complex poro-educators and technologies for the production of nonautoclaved cellular concretes based on them is relevant in terms of finding ways to improve the operational properties and manufacturability of the production of this material. The purpose of this work is to develop dry mix compositions for non-autoclaved cellular concrete.
PROSPECTS OF PROCESSING OF RAW MATERIALS WITH DIVERSIFICATION OF DIRECTIONS OF PRODUCTION OF PRODUCTS
Authors: Айсунгуров Н.Д. , Эльмурзаев А.А. 
Published: September 2021

В статье приводятся аналитические данные по эффективности диверсификации процессов переработки сырья агропромышленного комплекса, указана необходимость модернизации промышленного оборудования, в соответствии с развитием современных технологий в области цифровизации промышленных процессов переработки сырья. Также приведен сравнительный анализ курдючного жира относительно бараньего и говяжьего жира. Показана эффективность переработки животного жира, с последующим гранулированием, после предварительного копчения на опытной установке и целесообразность гранулирования в плане удобства пользования для потребителя.
The article provides analytical data on the efficiency of diversification of the processing of raw materials in the agro-industrial complex, indicates the need to modernize industrial equipment, in accordance with the development of modern technologies in the field of digitalization of industrial processes for processing raw materials. A comparative analysis of fat tail fat versus lamb and beef fat is also provided. The efficiency of animal fat processing, followed by granulation, after preliminary smoking in a pilot plant, and the feasibility of granulation in terms of ease of use for the consumer are shown.
VERNACULAR ARCHITECTURE OF NOGAYS OF THE PERIOD OF NOMADIC CATTLE BREEDING
Authors: Канокова Ф.Ю. 
Published: September 2021

В настоящем исследовании рассматриваются особенности вернакулярной архитектуры ногайцев. Выделяется культурно-бытовой комплекс, характерный для скотоводческо-кочевой формы производственно-хозяйственной деятельности этноса. На примере неразборных юрт «отав» и сборно-разборных юрт «терме» выявляются технологические и художественно-конструктивные особенности внешней и внутренней структуры каждого типа и подтипа мобильного жилища, а также архитектурного комплекса в целом.
This study examines the features of the vernacular architecture of the Nogai. The cultural and household complex, characteristic of the pastoral-nomadic form of production and economic activity of the ethnos, is distinguished. On the example of non-collapsible yurts «otav» and collapsibleyurts «terme», technological and artistic-constructive features of the external and internal structure of each type and subtype of a mobile dwelling and the architectural complex as a whole are revealed.
COMPARATIVE TESTS OF LOCAL AND TRANSPORTED LARGE AGGREGATE FOR COMPRESSION STRENGTH IN CONCRETE OF DIFFERENT CLASSES
Authors: Муртазаева Т.С-А. , Сайдумов М.С. , Джандаров А.Ш. , Абдрахманова Д.Х-Б. 
Published: September 2021

Результаты сравнительных испытаний местного и привозного крупного заполнителя на прочность при сжатии в бетонах разных классов. Проанализирован характер разрушения бетона. Представлены некоторые пути решения проблемы обогащения крупного заполнителя.Работа выполнена при финансовой поддержке РФФИ в рамках научного проекта № 18-48-200001.Results of comparative tests of local and imported coarse aggregate for compressive strength in concretes of different classes. The nature of concrete destruction is analyzed. Some ways of solving the problem of coarse aggregate enrichment are presented.This work was carried out with the financial support of the Russian Foundation for Basic Research in scientific project No. 18-48-200001.
Monolingualer und bilingualer Erwerb von Wortbildungsstrategien im Deutschen
Authors: Scherger Anna-Lena , Kliemke Lena 
Published: September 2021

The present study investigates word formation processes and strategies in monolingual and bilingual children by age 7 to 8. Using an elicitation task in form of naming of low frequent complex objects, it is analyzed whether bilingual children use other word formation strategies than monolinguals do. Therefore, N=9 monolinguals and N=9 bilinguals were tested. N=268 elicited reactions were analyzed. Results show bilinguals to use the same word formation strategies to the same extent as monolinguals do. Compounding overweighs derivation in each child. However, a more in-depth qualitative analysis shows that the complex compounds formed by bilingual children disregard the German composition rule of right-hand heads to a significantly higher extent than the monolingual children do. Since this acquisition process has been reported for German monolingual 2-year old children, this result is interpreted as a delayed acquisition process rather than a transfer from the respective first language.

Dieser Beitrag ist ursprünglich im Peter-Lang-Verlag erschienen (https://www.ingentaconnect.com/contentone/plg/jwf/2021/00000005/00000002/art00001)