bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative contrast-enhanced ultrasound for intramedullary spinal neoplasms: patient series
Authors: Barkley Ariana , McGrath Lynn B. , Hofstetter Christoph P. 
Published: May 2021

BACKGROUNDPrimary intramedullary spinal tumors cause significant morbidity and death. Intraoperative ultrasound as an adjunct for localization and monitoring the extent of resection has not been systematically evaluated in these patients; the effectiveness of intraoperative contrast-enhanced ultrasound (CEUS) remains almost completely unexplored.OBSERVATIONSA retrospective case series of patients at a single institution who had consented to the off-label use of intraoperative CEUS was identified. Seven patients with a mean age of 52.8 ± 15.8 years underwent resection of intramedullary tumors assisted by CEUS performed by a single attending neurosurgeon. Histopathological evaluation revealed 3 cases of hemangioblastoma, 1 case of pilocytic astrocytoma, 2 cases of ependymoma, and 1 case of subependymoma. Contrast enhancement correlated with gadolinium enhancement on preoperative magnetic resonance imaging. Intraoperative CEUS facilitated precise lesion localization and myelotomy planning. Dynamic CEUS studies were useful in demonstrating the blood supply to lesions with a dominant vascular pedicle. Regardless of contrast uptake, the differential enhancement between spinal cord tissue and neoplasm assisted in determining interface boundaries.LESSONSIntraoperative CEUS constitutes a useful adjunct for the intraoperative delineation of contrast-enhancing intramedullary tumors and in vivo confirmation of gross-total resection. Systematic investigation is needed to establish the role of CEUS for resection of intramedullary spinal tumors of various pathologies.
Endovascular selective hypothermia facilitates giant aneurysm clipping: illustrative case
Authors: Mattingly Thomas K. , Lopez-Ojeda Pablo , Arango Miguel , Harle Chris , Kakani Nirmal , Allen Peter , Lehrbass Barbara , Lownie Stephen P. 
Published: May 2021

BACKGROUNDThe authors present a case of selective hypothermia used for neuroprotection during clipping of a giant partially thrombosed middle cerebral artery (MCA) aneurysm. Although these cases have traditionally required deep hypothermic cardiac arrest, this case illustrates a novel and entirely endovascular solution that avoids cardiac standstill and whole-body cooling.OBSERVATIONSThis is, to the authors’ knowledge, the first case in human surgery of a catheter-based selective hypothermic circuit used to facilitate MCA trapping for almost 30 minutes. Core temperatures never dropped below 34°C, and the patient recovered uneventfully and has been well for over 5 years.LESSONSThe technical nuances and physiological changes unique to selective hypothermia are discussed.
Repair of internal carotid artery injury with aneurysm clip during endoscopic endonasal surgery: illustrative case
Authors: Fustero de Miguel David , López López Laura Beatriz , Avedillo Ruidíaz Amanda , Orduna Martínez Javier , Casado Pellejero Juan , Moles Herbera Jesús Adrián 
Published: May 2021

BACKGROUNDOne of the most feared and dangerous scenarios that can appear during an endoscopic endonasal surgery (EES) is the iatrogenic injury of the internal carotid artery (ICA). Several methods, along with a variety of outcomes, have been described to deal with this complication. To the authors’ knowledge, this is the first report on the use of a Yasargil-type aneurysm clip to solve an ICA injury, preserving the artery’s patency and having a long-term follow-up. The authors discuss the advantages and disadvantages of other vessel preservation techniques compared with clipping.OBSERVATIONSA visually impaired 56-year-old woman was diagnosed with a giant nonfunctional pituitary tumor that invaded the sphenoidal sinus, anterior and posterior ethmoidal cells, and both cavernous sinuses, with suprasellar extension and optochiasmatic compression. The patient underwent EES, and during the final resection phase her left ICA was injured, with massive hemorrhage.LESSONSICA injury during endoscopic skull base surgery carries high mortality and morbidity; it is essential to maintain carotid flow when possible to avoid short-term and long-term consequences. There are several techniques depicted in the literature to deal with this situation. The authors report the use of a Yasargil mini-clip to deal with the injury for a positive outcome: primary hemostasis, vessel preservation, and no postoperative complications.
Giant pituitary macroadenoma of stem cell origin: illustrative case
Authors: Asuzu David T. , Burke Rebecca M. , Hakim Jeffrey , Coss Dylan , Park Min S. , Payne Spencer C. , Jane John A. 
Published: May 2021

BACKGROUND
Giant pituitary macroadenomas with a diameter >4 cm are rare tumors, accounting for only about 5% of pituitary adenomas. They are more difficult to maximally resect safely owing to limited access as well as encasement of adjacent structures. Acidophil stem cell adenomas are rare immature neoplasms proposed to derive from common progenitor cells of somatotroph and lactotroph cells. These adenomas comprise about 4.3% of surgically removed pituitary adenomas. No previous reports have described acidophil stem cell adenomas that grow to the size of giant macroadenomas. This rare entity poses special challenges given the need for maximal safe resection in an immature neoplasm.

OBSERVATIONS
The authors report a 21-year-old female who presented with 3 years of progressive visual decline and a giant macroadenoma. She underwent endoscopic transsphenoidal surgery for decompression. Given the tumor size and involvement of adjacent critical structures, gross-total resection was not achieved. The authors review the literature on giant pituitary adenomas and provide a discussion on clinical management for this rare entity.

LESSONS
The authors present a very rare case of a giant pituitary adenoma of acidophil stem cell origin and discuss the technical and management challenges in this rare entity.
Asymptomatic superficial siderosis after posterior fossa tumor resection: illustrative case
Authors: Goyal Anshit , Nesvick Cody L. , Spear Joshua A. , Daniels David J. 
Published: May 2021

BACKGROUND
Superficial siderosis of the central nervous system is a rare syndrome notable for the presence of hemosiderin deposition due to chronic, repetitive hemorrhages into the subarachnoid space.

OBSERVATIONS
The authors presented a case of superficial siderosis in a 14-year-old girl. It arose as a late postoperative complication after resection of a medulloblastoma. Despite the patient being asymptomatic, surveillance imaging demonstrated diffuse hemosiderin deposition within the cerebellar folia and cisternal segments of cranial nerves VII and VIII on gradient echo (GRE) sequences. Formal audiometric testing demonstrated bilateral loss of high-frequency tone recognition consistent with early sensorineural hearing loss. A pseudomeningocele due to multiple dural defects was identified as the likely cause, and definitive surgical repair was performed. Intraoperatively, the presence of blood-tinged cerebrospinal fluid confirmed a diagnosis of superficial siderosis.

LESSONS
This case highlighted the potential need to routinely include GRE or susceptibility-weighted sequences in postoperative surveillance imaging after resection of pediatric posterior fossa tumors.
Numerical analysis of seismic behavior of square concrete filled steel tubular columns
Authors: Phan Hao Dinh 
Published: May 2021

This paper presents a numerical analysis of the seismic behavior of square concrete filled steel tubular (CFST) columns. Finite element analysis (FEA) models in ABAQUS software were used to simulate a series of columns subjected to axial compression and cyclic lateral loading. The CFST columns were simulated using nonlinear tri-dimensional (3-D) finite elements for the infilled concrete, and nonlinear two-dimensional (2-D) finite elements for the steel tube. The feasibility of the FEA model has been validated by published experimental results. The validated FEA model was further extended to conduct parametric studies with various parameters including axial load level (n), width-to-thickness ratio of steel tube (B/t), and concrete strength. The numerical analysis results reveal that with the same B/t and constitute materials, the higher the axial compression, the lower the shear strength and deformation capacity were. The thicker steel wall (B/t = 21) resulted in higher strength and larger deformation capacity of the column. Increasing concrete strength helped to significantly develop the column’s shear strength in all cases. Meanwhile, it just led to an increase in deformation capacity in some cases depending on n and B/t. This study also reveals that the square CFST columns with B/t of 21 satisfy the seismic performance demand in high seismic zones (ultimate interstory drift ratio (IDRu) not less than 3% radian) under the two axial load levels, 0.35 and 0.45, but the columns with B/t of 28 satisfy the above demand under just one axial load level of 0.35.
Keywords:
square concrete filled steel tubular (CFST) columns; finite element analysis (FEA) model; width-to-thickness ratio (B/t); high axial load level; seismic behavior.
SURVIVAL OF MYELOMA PATIENTS RECEIVING BISPHOSPHONATES IN A "REAL LIFE" EXPERIENCE: POTENTIAL IMPACT ON RISK OF OSTEONECROSIS OF THE JAW (ONJ)
Authors: Monaco Federico , Fusco Vittorio , Limberti Giulia , Fasciolo Antonella , Ferrero Elisabetta , Brigo Paola , Tartara Daniela , Baraldi Anna , Catania Gioacchino , Ladetto Marco 
Published: May 2021

Background. Expected survival of myeloma patients increased in recent decades, after introduction of new drugs and strategies. Median survival has been reported about 5 years, but it is very variable, according to age, comorbidities, disease stage, etc.

Almost all myeloma patients receive bisphosphonates as antiresorptive treatment (with denosumab recently approved as an alternative) shortly after diagnosis, and 1%-15% of them develop Osteonecrosis of the Jaw (ONJ), within some years of treatment (or observation). Expected survival of myeloma patients can influence the choice of ONJ treatment among possible options.

Methods. Charts of myeloma patients receiving bisphosphonates and observed at the Haematology Unit of Alessandria Hospital in years 2005-2020 have been reviewed. Kaplan-Meier actuarial survival was evaluated.

Results. Median survival from the start of antiresorptive treatment of 244 patients was 5.36 years - with 79%, 69%, 60%, 52% of patients alive at 2, 3, 4, 5 years. At 7 and 10 years, 41.3% and 30.2% of patients were alive.

ONJ occurred in 7 patients, after a median of 6.3 years (range 0.5-13.2) from the start of treatment. Mean survival from the ONJ diagnosis time of those 7 patients was 2.9 years (range 0.5-6.0).

Conclusions: Expected survival of myeloma patients in a “real life” setting after the start of antiresorptive treatment is medially long in terms of years, with a large portion of patients exposed at risk of developing ONJ for more than 5 years. A surgical treatment of ONJ is warranted, being expected survival not so short to hamper jawbone surgery.
Is It Still Profitable to Grow Lychee in Florida?
Authors: Evans Edward , Degner Robert , Crane Jonathan , Rafie Ray , Balerdi Carlos 
Published: May 2021

In the following analysis, we examine developments within the U.S. lychee industry and focus on the costs and returns of producing lychee in Florida to determine whether farmers can still make a profit from growing this commodity. This is EDIS document FE496, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL. Published November 2004.
https://edis.ifas.ufl.edu/fe496
MODIFIKASI PEMBUAT MOL LIMBAH ORGANIK BAHAN PRAKTIKUM DI LABORATORIUM POLITEKNIK PERTANIAN NEGERI PAYAKUMBUH
Authors: Maiza Linda Tri , Yubniati Yubniati , Hermansyah Rio 
Published: May 2021

Salah satu pemanfaatan limbah organik dari sisa praktikum di lingkungan Politeknik Pertanian Negeri Payakumbuh adalah sebagai bahan pembuatan MOL. MOL dijadikan bioaktivator pembuatan kompos dan pupuk organik cair yang dapat digunakan kegiatan budidaya tanaman di lingkungan Institusi. Alat pembuat MOL memakai ember plastik bertutup, menghasilkan kualitas MOL masih rendah, ditandai dengan aroma MOL berbau busuk, larutan yang dihasilkan banyak endapan , serta tidak efisien dalam saat panen. Penelitian ini bertujuan untuk mengetahui kinerja alat pembuatn MOL yang sudah dimodifikasi.Pengamatan meliputi dari segi kualitas aroma, kebersihan, efisiensi waktu dan tenaga. Pengujian kinerja pembuat alat pembuat MOL yang belum dimodifikasi dan sudah di modifikasi dengan memakai bahan sayuran dan buah-buahan. Dari hasil pengujian menunjukkan bahwa alat modifikasi pembuat MOL yang menggunakan saringan dan kran menghasilkan kualitas MOL yang baik, ditandai larutan MOL dengan aroma khas dan penampakan larutannya bersih, tidak menimbulkan kendala saat panen dari segi waktu dan tenaga. Dapat disimpulkan bahwa alat pembuat MOL yang di modifikasi memakai saringan dengan menambahkan kran dibagian dasar wadahnya memberi tingkat kualitas MOL lebih baik.
PENGARUH PENGGUNAAN ZPT ALAMI DAN BUATAN TERHADAP PERTUMBUHAN SETEK TANAMAN DELIMA (Punica granatum L.)
Authors: Tanjung Tiffany Yuandara 
Published: May 2021

Delima (Punica granatum L.) adalah tanaman yang berasal dari Persia (Iran), Afganistan dan wilayah pegunungan Himalaya yang biasa dimanfaatkan sebagai tanaman pekarangan dan obat-obatan, dimana buahnya mengandung berbagai nutrisi dan vitamin yang dimanfaatkan untuk kesehatan dan berbagai jenis penyakit. Perbanyakan vegetatif stek tanaman delima dilakukan untuk menyediakan bibit tanaman dalam jumlah yang lebih banyak dan dalam waktu yang singkat serta memiliki sifat yang sama seperti induknya. Zat pengatur tumbuh (ZPT) yang diberikan berperan dalam mengatur percepatan pertumbuhan stek dengan kandungan auksin dan sitokinin. Tujuan dari percobaan ini adalah untuk: mengetahui pengaruh penggunaan berbagai jenis ZPT terhadap pertumbuhan stek tanaman delima, mendapatkan jenis ZPT yang terbaik terhadap pertumbuhan stek tanaman delima. Percobaan tugas akhir ini dilakukan pada tanggal 24 Februari sampai 11 April 2020 di kebun percobaan UPTD BBI PPH SUMBAR. Parameter yang diamati dari percobaan ini: persentase tumbuh (%), jumlah tunas, panjang akar dan jumlah akar. Hasil dari percobaan ini adalah persensate tumbuh yang baik terdapat pada perlakuan buah pisang dan rapid root yaitu 80%, jumlah tunas terbanyak pada perlakuan buah pisang 2,6 tunas, panjang akar yang terpanjang pada perlakuan air kelapa 1,4 cm, jumlah akar terbanyak pada perlakuan air kelapa 6 akar. Kesimpulan dari perbanyakan ini adalah Penggunaan berbagai jenis ZPT memiliki pengaruh terhadap pertumbuhan stek delima, penggunaan ZPT buah pisang memiliki hasil yang baik pada persentase tumbuh dan jumlah tunas. ZPT air kelapa memiliki hasil yang baik untuk panjang dan jumlah akar yang diamati hingga 5 minggu setelah tanam. Berdasarkan kesimpulan disarankan untuk menggunakan ZPT rapid root.
EKSTRAKSI PASIR SLIKAT (SILLICOND SAND) SEBAGAI MATERIAL SUBTRAT PADA SENSOR GAS DAN TURUNANNYA
Authors: Alamsyah Tossin 
Published: May 2021

Pasir silika adalah material dari kristal silika (SiO2) dan senyawa lainnya yang mengandung material lain selama proses deposisi, memiliki komposisi gabungan dari SiO2, Fe2O3, Al2O3, CaO, MgO, dan K2O. Sensitivitas atau responsivitas suatu sensor gas dapat dipengaruhi oleh porositas pada permukaan substrat, umumnya substrat material dari sensor gas digunakan alumina (Al2O3) atau dioxside silikon (SiO2).Pada artikel ini membahas tentang hasil proses sintering pada pasir silika yang bertujuan untuk mendapatkan struktur SiO2 yang baik, khusunya dalam parameter konduktivitas termal. Proses sintering dilakukan pada pasir silika dengan campuran almunium sulfat (AlSo4) pada 1600o untuk hasil kemudian tumbuk menjadi tiga (3) buah sampel yaitu sampel A ukuran mesh 300, Sampel B ukuran mesh 500 mesh dan sampel C ukuran mesh 1000 mesh.Hasil pengamatan, jika tiga sampel dipanaskan (T) sampai 1000 , sampel C memiliki responsivitas tinggi untuk dibandingkan dengan sampel a dan b dengan rasio 5,7; 5,4 dan 4,8. Disimpulkan bahwa bahan substrat dengan ukuran mesh kecil (sampel C, 1000) memiliki resistivitas termal yang tinggi dibandingkan dengan ukuran bahan mesh rendah , sampel A (mesh 300) dan dan B(mesh 500).Akhirnya ketika diimplementasikan dalam model sensor Gas CO, dihasilkan bahwa sample C dengan mesh 1000 memiliki thermal sensitivitas yang lebih besar dibandingkan dengan sampel B dan A
Influence of Mall Shopping Culture on Online Shopping Preferences: An Emerging Economy Perspective using the Technology Acceptance Model
Authors: John Reshma , Dani Anita 
Published: May 2021

Growth of e-commerce activities are keeping up pace with the rapid progress in the development and availability of internet. However, the availability of internet technology and its penetration does not automatically imply consumer preference of online shopping. This study aims to examine the factors influencing the decisions of consumers for engaging in online shopping in the context of UAE, and inquires whether the prevalence of mall culture has an impact on the online shopping adoption by consumers. The Technology Acceptance Model (Davis 1989) was used to assess consumer perceptions and intentions towards online shopping. Data was collected through online surveys using convenience sampling method. From the analysis of sample data, there is sufficient evidence to conclude that online shopping is still not very popular in the UAE as residents prefer to do shopping in malls. The findings of the study are relevant to the e-commerce retail entities operating in countries where the mall culture is an important influence in the retail scenario, as this will help them in formulating their strategy to accommodate the shopping preferences of both online and in-store customers. The impact of the COVID-19 pandemic is also considered on the objectives and findings of the study.
Pengaruh Latihan Plyometrics (Hurdle Hops dan Ladder Drill) Terhadap Kecepatan Dribbiling Futsal Putri Tim Jugador Bonita Rafflesia
Authors: Ilham Tri Rahmat , Pujianto Dian , Arwin Arwin 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh latihan plyometrics hurdle hops dan ladder drill terhadap kecepatan dribbling futsal putri tim jugador bonita rafflesia. Penelitian ini menggunakan jenis penelitian eksperimen dengan teknik pengumpulan data one grup pre-test post-test. Dengan sampel 20 atlet dari seluruh populasi. Berdasarkan hasil penelitian dapat diketahui terdapat peningkatan kecepatan dribbling yang dibuktikan dengan uji T diperoleh Thitung 5,348 > Ttabel 1,725. Dengan demikian hipotesis Ha diterima terdapat pengaruh variasi latihan hurdle hops dan ladder drill terhdap kecepatan dribbling futsal putri tim jugador bonita rafflesia sebesar 82%.
Genetic Diversity and Prevalence of Giardia duodenalis in Qatar
Authors: Chourabi Marwa , Boughattas Sonia , Abdallah Atiyeh M. , Ismail Ahmed , Behnke Jerzy M. , Al-Mekhlafi Hesham M. , Abu-Madi Marawan 
Published: May 2021

BackgroundGiardia duodenalis is a common human intestinal parasite worldwide, and the causative agent of diarrhea, with the severity of disease ranging from asymptomatic to intense and debilitating infection. G. duodenalis is known to consist of eight genetically distinct assemblages, named from A to H. No data available on the genotypes and genetic diversity of G. duodenalis circulating in Qatar.MethodsWe genotyped 54 human Giardia isolates, collected from asymptomatic immigrants in Qatar, using a multilocus genotyping (MLGs) tool. We also investigated relationships between the subjects’ genotypes and their demographic data.ResultsGenomic DNA from 54 isolates were tested by PCR and sequence analysis at three loci: glutamate dehydrogenase (gdh), β-giardin (bg) and triose phosphate (tpi)). Assemblage A was identified in nine (16.67%), assemblage B in thirty (55.55%), and a mixture of assemblages A+B in fifteen (27.78%) isolates. All assemblage A isolates, genotyped in different loci, were assigned to sub-assemblage AII, and six of them had MLGs AII-1 while one new MLG was identified in two isolates. Sequences of assemblage B isolates have high level of genetic diversity and high presence of heterogeneous peaks, especially within the gdh gene. No significant associations between genotypes and the immigrants’ demographic data were found due to the extensive number of new variants.ConclusionsMLGs was used herein to genotype 54 immigrant Giardia isolates. The high level of genetic variability found in our isolates hampered MLGs determination, more investigations are now required to consolidate our findings, and to enable a comprehensive understanding of the diversity within G. duodenalis assemblage B isolates.
Exosome-Contained APOH Associated With Antiphospholipid Syndrome
Authors: Tan Yuan , Bian Yiding , Song Yunfeng , Zhang Qinhua , Wan Xiaoping 
Published: May 2021

BackgroundAntiphospholipid syndrome (APS) is a systemic autoimmune disease that can lead to thrombosis and/or pregnancy complications. Exosomes, membrane-encapsulated vesicles that are released into the extracellular environment by many types of cells, can carry signals to recipient cells to affect angiogenesis, apoptosis, and inflammation. There is increasing evidence suggesting that exosomes play critical roles in pregnancy. However, the contribution of exosomes to APS is still unknown.MethodsPeripheral plasma was collected from healthy early pregnancy patients (NC-exos) and early pregnancy patients with APS (APS-exos) for exosome extraction and characterization. The effect of exosomes from different sources on pregnancy outcomes was determined by establishing a mouse pregnancy model. Following the coincubation of exosomes and human umbilical vein endothelial cells (HUVECs), functional tests examined the features of APS-exos. The APS-exos and NC-exos were analyzed by quantitative proteomics of whole protein tandem mass tag (TMT) markers to explore the different compositions and identify key proteins. After incubation with HUVECs, functional tests investigated the characteristics of key exosomal proteins. Western blot analysis was used to identify the key pathways.ResultsIn the mouse model, APS-exos caused an APS-like birth outcome. In vitro experiments showed that APS-exos inhibited the migration and tube formation of HUVECs. Quantitative proteomics analysis identified 27 upregulated proteins and 9 downregulated proteins in APS-exos versus NC-exos. We hypothesized that apolipoprotein H (APOH) may be a core protein, and the analysis of clinical samples was consistent with finding from the proteomic TMT analysis. APOH-exos led to APS-like birth outcomes. APOH-exos directly enter HUVECs and may play a role through the phospho-extracellular signal-regulated kinase pathway.ConclusionsOur study suggests that both APS-exos and APOH-exos impair vascular development and lead to pregnancy complications. APOH-exos may be key actors in the pathogenesis of APS. This study provides new insights into the pathogenesis of APS and potential new targets for therapeutic intervention.