bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geological and technological justification of the bottom-hole zone treatment of wells and formations of the Langepas group of fields
Authors: Yaskin S A , Mukhametshin V V , Kuleshova L S 
Published: February 2021

Abstract
Based on the geological and routine analysis are represented the effective application areas of methods of simulating production and enhanced oil recovery of fields developed by the TPP “Langepasneftegaz”. Based on laboratory experiments, the composition of composite systems of recovery methods on productive formations has been established. The technologies adaptation of the bottom-hole zone treatment of wells and formations of the Langepas group of fields was carried out.
The controlled SWAP test for determining quantum entanglement
Authors: Foulds Steph , Kendon Viv , Spiller Tim 
Published: February 2021

Abstract
Quantum entanglement is essential to the development of quantum computation, communications, and technology. The controlled SWAP test, widely used for state comparison, can be adapted to an efficient and useful test for entanglement of a pure state. Here we show that the test can evidence the presence of entanglement (and further, genuine n-qubit entanglement), can distinguish entanglement classes, and that the concurrence of a two-qubit state is related to the test’s output probabilities. We also propose a multipartite measure of entanglement that acts similarly for n-qubit states. The average number of copies of the test state required to detect entanglement decreases for larger systems, to four on average for many (n ≳ 8) qubits for maximally entangled states. For non-maximally entangled states, the number of copies required to detect entanglement increases with decreasing entanglement. Furthermore, the results are robust to second order when typical small errors are introduced to the state under investigation.
Investigating the effects of B-site Cr doping on the structural, magnetic and magnetocaloric properties of La1.4Ca1.6Mn2−

x
Cr
x
O7 (0 ⩽ x ⩽ 0.4) bilayer manganites
Authors: Kumar Akshay , Kumari Kavita , Koo Bon Heun 
Published: February 2021

Abstract
In this work, we describe the preparation of a series of Cr-substituted La1.4Ca1.6Mn2−x
Cr
x
O7 (x = 0.0, 0.1, 0.2, 0.3, 0.4) double-layer perovskite compounds using a solid-state reaction method. The XRD patterns of all the samples are characterized by a tetragonal structure with a bilayer Ruddlesden–Popper phase. Scanning electron microscope micrographs of the doped samples display ambiguous granular variation and distribution, thereby establishing that the Cr content adversely influences the diffusion kinetics during the sintering process. Combined field-cooled moment vs temperature (M–T) and isothermal magnetization measurements establish the presence of a ferromagnetic to paramagnetic transition in all samples. Furthermore, the second-order nature of the transition is identified using the Arrott plots for these compounds. The maximum values of the change in isothermal entropy are found to be 2.98 J kgK−1, 2.39 J kgK−1, 1.48 J kgK−1, 1.29 J kgK−1, and 1.13 J kgK−1 for samples with x = 0.0, 0.1, 0.2, 0.3, and 0.4, respectively, when exposed to a field of 2.5 T. The entropy curves of the pristine sample are bounded within a narrow range of temperatures while the isothermal entropy curves are broadly expanded over a range of temperatures upon Cr-doping. The broad entropy profiles of the Cr-doped compounds versus temperature suggest a relatively high magnetocaloric potential, compared to the parent compound.
Facelift Part II: Surgical Techniques and Complications
Authors: Hashem Ahmed M , Couto Rafael A , Surek Chris , Swanson Marco , Zins James E 
Published: February 2021

AbstractAlthough previous publications have reviewed face and necklift anatomy and technique from different perspectives, seldom were the most relevant anatomical details and widely practiced techniques comprehensively summarized in a single work. As a result, the beginner is left with a plethora of varied publications that require sorting, rearrangement, and critical reading. A recent survey of US plastic surgery residents and program directors disclosed less facility with facelift surgery compared with aesthetic surgery of the breast and trunk. To this end, 4 of the widely practiced facelift techniques (ie, minimal access cranial suspension-lift, lateral-SMASectomy, extended-SMAS, and composite rhytidectomy) are described in an easy review format. The highlights of each are formatted followed by a summary of complications. Finally, the merits and limitations of these individual techniques are thoroughly compared and discussed.Level of Evidence: 4
Anthropogenic noise alters parental behavior and nestling developmental patterns, but not fledging condition
Authors: Pandit Meelyn Mayank , Eapen James , Pineda-Sabillon Gabriela , Caulfield Margaret E , Moreno Alexander , Wilhelm Jay , Ruyle Jessica E , Bridge Eli S , Proppe Darren S 
Published: February 2021

Abstract
Anthropogenic noise is a ubiquitous feature of the American landscape, and is a known stressor for many bird species, leading to negative effects in behavior, physiology, reproduction, and ultimately fitness. While a number of studies have examined how anthropogenic noise affects avian fitness, there are few that simultaneously examine how anthropogenic noise impacts the relationship between parental care behavior and nestling fitness. We conducted Brownian noise playbacks for 6 h a day during the nesting cycle on Eastern Bluebird (Sialia sialis) nest boxes to investigate if experimentally elevated noise affected parental care behavior, nestling body conditions, and nestling stress indices. We documented nest attendance by adult females using radio frequency identification (RFID), and we assessed nestling stress by measuring baseline corticosterone levels and telomere lengths. Based on the RFID data collected during individual brood cycles, adult bluebirds exposed to noise had significantly higher feeding rates earlier in the brood cycle than adults in the control group, but reduced feeding rates later in the cycle. Nestlings exposed to noise had higher body conditions than the control nestlings at 11 days of age, but conditions equalized between treatments by day 14. We found no differences in nestling baseline corticosterone levels or nestling telomere lengths between the two treatment groups. Our results revealed that noise altered adult behavior, which corresponded with altered nestling body condition. However, the absence of indicators of longer-term effects of noise on offspring suggests adult behavior may have been a short-term response.
Deep-ABPpred: identifying antibacterial peptides in protein sequences using bidirectional LSTM with word2vec
Authors: Sharma Ritesh , Shrivastava Sameer , Kumar Singh Sanjay , Kumar Abhinav , Saxena Sonal , Kumar Singh Raj 
Published: February 2021

AbstractThe overuse of antibiotics has led to emergence of antimicrobial resistance, and as a result, antibacterial peptides (ABPs) are receiving significant attention as an alternative. Identification of effective ABPs in lab from natural sources is a cost-intensive and time-consuming process. Therefore, there is a need for the development of in silico models, which can identify novel ABPs in protein sequences for chemical synthesis and testing. In this study, we propose a deep learning classifier named Deep-ABPpred that can identify ABPs in protein sequences. We developed Deep-ABPpred using bidirectional long short-term memory algorithm with amino acid level features from word2vec. The results show that Deep-ABPpred outperforms other state-of-the-art ABP classifiers on both test and independent datasets. Our proposed model achieved the precision of approximately 97 and 94% on test dataset and independent dataset, respectively. The high precision suggests applicability of Deep-ABPpred in proposing novel ABPs for synthesis and experimentation. By utilizing Deep-ABPpred, we identified ABPs in the tail protein sequences of Streptococcus bacteriophages, chemically synthesized identified peptides in lab and tested their activity in vitro. These ABPs showed potent antibacterial activity against selected Gram-positive and Gram-negative bacteria, which confirms the capability of Deep-ABPpred in identifying novel ABPs in protein sequences. Based on the proposed approach, an online prediction server is also developed, which is freely accessible at https://abppred.anvil.app/. This web server takes the protein sequence as input and provides ABPs with high probability (&gt;0.95) as output.
Places that matter: Australia’s crisis intervention framework and voter response
Authors: Weller Sally 
Published: February 2021

AbstractThis article contributes to understandings of geographies of discontent by focusing on the way that political frameworks condition the demand for fringe or protest voting. It discusses how Australia’s federal political framework, preferential voting system and timely crisis intervention policies combine to reduce the demand for fringe voting. The local effects of this system are illustrated via an examination of voting patterns in two disadvantaged and deindustrialising locations in the State of Victoria. The conclusion suggests that European jurisdictions have much to learn from the Australian example.
Elevated septal wall stress - a driver of left ventricular dysfunction in left bundle branch block?
Authors: Sletten OJ , Aalen JM , Remme EW , Izci H , Duchenne J , Larsen CK , Hopp E , Galli E , Sirnes PA , Kongsgard E , Donal E , Voigt JU , Smiseth OA , Skulstad H 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): The Norwegian Health Association

Background
Septal dysfunction is a main feature of left bundle branch block (LBBB), and increasing wall stress is a proposed mechanism of heart failure development in LBBB patients. To try to reveal the pathophysiologic pathway from dyssynchrony to heart failure, we investigated the relationship between septal and left ventricular (LV) lateral wall stress in patients with LBBB.

Hypothesis
Increased septal wall stress causes septal dysfunction in LBBB.

Methods
We included 24 LBBB-patients (65 ± 11 years, 11 males) with LV ejection fraction (EF) ranging from 18 to 67%, and 8 healthy controls (58 ± 10 years, 4 males). Wall stress was calculated at peak LV pressure (LVP) according to the law of La Place ([LVP x radius]/[wall thickness]). Wall thickness was measured using M-mode, and regional curvature was measured in mid-ventricular shortaxis from 2D echocardiographic images. We used a previously validated non-invasive method to estimate LVP from brachial blood pressure and adjusted for valvular events. Myocardial scar was ruled out by late gadolinium enhancement cardiac magnetic resonance imaging.

Results
Wall stress was significantly higher in septum than LV lateral wall at peak LVP (48 ± 12 vs 37 ± 11 kPa, p &lt; 0.01) in LBBB patients, while no difference was seen in the controls (Figure A). In patients, septal wall thickening showed a strong correlation with LVEF (r = 0.77, p &lt; 0.01) (Figure B). Similar correlation was not significant for the LV lateral wall (r = 0.13, NS). Attenuation of septal wall thickening in LBBB-patients correlated well with increasing septal wall stress (r=-0.60, p &lt; 0.01). Wall thickening and stress did not correlate in the LV lateral wall (r=-0.14, NS).

Conclusion
Increased septal wall stress is associated with reduced systolic thickening in patients with LBBB. Septal wall thickening, in contrast to LV lateral wall thickening, was correlated to global LV function. These findings suggest that septal remodeling which could have normalized septal wall stress, was not achieved and heart failure may develop.
Abstract Figure.
Diastolic dyssynchrony in patients with LV only fusion pacing CRT without RV lead
Authors: Gurgu A , Petrescu L , Vacarescu C , Luca CT , Mornos C , Crisan S , Lazar MA , Cozma D 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
CRT improves both systolic and diastolic function, thus increasing cardiac output. However, less data is available concerning diastolic dyssynchrony and fusion pacing CRT. The aim of our study was to assess the outcome of LV diastolic asynchrony in a population of fusion pacing CRT without right ventricular (RV) lead.

Methods
Prospective data were collected from a cohort of patients (pts) with right atrium/left ventricle leads (RA/LV CRT). Baseline and every 6 months follow-up included standard ETT and classical dyssynchrony parameter measurements. Diastolic dyssynchrony was done by offline speckle-tracking derived TDI timing assesment of the simultaneity of E" and A" basal septal and lateral wall 4 chamber view. New parameters were introduced: E" and respectively A" time (E"T / A"T) as the time difference between E" (respectively A" ) peaks septal and lateral wall. Exercise tests, drugs optimization and device individual programmimg were systematically performed in order to maintain constant fusion and improve CRT response. Patients were divided in three groups: super-responders (SR), responders (R) and non responders (NR).

Results
Sixty-two pts (35 male) aged 62 ± 11 y.o. with idiopathic DCM implanted with a RA/LV CRT were analyzed: 34%SR / 61%R / 5%NR. Baseline initial characteristics: QRS 164 ± 18 ms; EF 27 ± 5.2; 29% had type III diastolic dysfunction (DD), 63% type II DD, 8% type I DD. Average follow-up was 45 ± 19 months; mean LVEF at the last follow-up was 37 ± 7.9%. The E"T decreased from 90 ± 20 ms to 25 ± 10 ms in SR with significant LV reverse remodelling (LV end-diastolic volume 193.7 ± 81 vs 243.2 ± 82 ml at baseline, p &lt; 0.0028) and lower LV filling pressures (E/E" 13.2 ± 4.6 vs 11.4 ± 4.5, p =0.0295). DD profile improved in 65% of R with a reduction in E/A ratio (1.46 ± 5.3 vs. 0.82 ± 3.9 at baseline, p= 0.4453). Non-sudden cardiac death occurred in 3 NR pts (2%) with type III DD, severe LA volume and larger E" T /A"T (E"T&gt; 85 msec A"T &gt; 30 msec). Significant cut off value calculated by ROC curve for LV diastolic dyssynchrony is E"T &gt; 80 ms and A"T of &gt; 25 msec.

Conclusions
Fusion pacing CRT without RV lead showed a positive outcome; improving LV diastolic dyssynchrony in responders and super-responders patients is obvious. Larger randomized studies are needed to define the role of diastolic asynchronism as a predictor of favorable response in fusion pacing.
Abstract Figure. Typical TDI patterns in LV fusion pacing
Importance of systematic right ventricular assessment in cardiac resynchronization therapy candidates: a machine-learning approach
Authors: Galli E , Le Rolle V , Smiseth OA , Duchenne J , Aalen JM , Larsen CK , Sade E , Hubert A , Anilkumar S , Penicka M , Linde C , Leclercq C , Hernandez A , Voigt J-U , Donal E 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Despite having all a systolic heart failure and broad QRS, patients proposed for cardiac resynchronization therapy (CRT) are highly heterogeneous and it remains extremely complicated to predict the impact of the device on left ventricular (LV) function and outcomes.

Objectives
We sought to evaluate the relative impact of clinical, electrocardiographic, and echocardiographic data on the left ventricular (LV) remodeling and prognosis of CRT-candidates by the application of machine learning (ML) approaches.

Methods
193 patients with systolic heart failure undergoing CRT according to current recommendations were prospectively included in this multicentre study. We used a combination of the Boruta algorithm and random forest methods to identify features predicting both CRT volumetric response and prognosis (Figure 1). The model performance was tested by the area under the receiver operating curve (AUC). We also applied the K-medoid method to identify clusters of phenotypically-similar patients.

Results
From 28 clinical, electrocardiographic, and echocardiographic-derived variables, 16 features were predictive of CRT-response; 11 features were predictive of prognosis.
Among the predictors of CRT-response, 7 variables (44%) pertained to right ventricular (RV) size or function. Tricuspid annular plane systolic excursion was the main feature associated with prognosis. The selected features were associated with a very good prediction of both CRT response (AUC 0.81, 95% CI: 0.74-0.87) and outcomes (AUC 0.84, 95% CI: 0.75-0.93) (Figure 1, Supervised Machine Learning Panel). An unsupervised ML approach allowed the identifications of two phenogroups of patients who differed significantly in clinical and parameters, biventricular size and RV function. The two phenogroups had significant different prognosis (HR 4.70, 95% CI: 2.1-10.0, p &lt; 0.0001; log –rank p &lt; 0.0001; Figure 1, Unsupervised Machine Learning Panel).

Conclusions
Machine learning can reliably identify clinical and echocardiographic features associated with CRT-response and prognosis. The evaluation of both RV-size and function parameters has pivotal importance for the risk stratification of CRT-candidates and should be systematically assessed in patients undergoing CRT.
Abstract Figure 1
Left ventricular remodelling patterns after MitraClip implantation: Do ischemic patients have the same benefit?
Authors: Viegas J , Reis JF , Branco LM , Galrinho A , Fiarresga A , Ramos R , Cacela D , Fernandes F , Celas M , Ferreira RC 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Percutaneous mitral valve repair has shown to prevent and even reverse adverse LV remodelling in most patients with moderate to severe mitral regurgitation (MR). This effect is, however, highly variable and may differ according to the MR etiology.

Objectives
The aim of the present study is to evaluate cardiac remodelling patterns and clinical outcomes after MitraClip implantation (MI) in ischemic and non-ischemic patients (P).

Methods
A standardized registry was prospectively performed between 2013 and 2019 for all P who underwent MitraClip insertion in a single terciary care centre. Transthoracic echocardiographic information was assessed at baseline and 1, 6, 12 and 18 months after MI. Student’s t-test was used to assess the procedure’s effect on several variables. Clinical outcomes were compared with the use of Fisher’s exact test or the chi-square test, as appropriate.

Results
46 P, 61% male, mean age 65 ± 14 years. 39% had ischemic MR. Dyslipidemia was more frequent in ischemic P (52% versus 93%, p= 0.002) as well as history of smoking (32% versus 67%, p= 0.022). Atrial fibrillation was significantly associated with non-ischemic etiology (75% versus 44%, p= 0.036). MI success rate was 87% (proper placement and reduction in MR to grade 2 or less), with an average of 1.5 clips. Considering the 37 P that completed 18 months of follow-up (FU), the echocardiographic parameters at baseline were: left ventricular ejection fraction (LVEF) 36 ± 12%, LV end-diastolic dimeter (LVEDD) 68.2 ± 10.2mm, LV end-systolic diameter (LVESD) 52.2 ± 13.5mm and left atrial diameter (LAD) 53.1 ± 6.7mm; there were no significant differences between groups. After MI, a compelling difference in LVEDD was noticeable early in the first month, with significant lower dimensions in non-ischemic P (66.6 ± 11.4 versus 72.8 ± 5.4, p= 0.039). Sustained differences in LVEDD were consistent at 6, 12 and 18 months (62.4 ± 12.3 versus 73.5 ± 7.4, p= 0.025). There was also a reduction in LVESD that became apparent in the sixth month (45.5 ± 15.1 versus 55.3 ± 9.8mm, p= 0.047) and that was sustained after 18 months from MI (45.4 ± 11.7 versus 58.3± 8.9, p= 0.012). No significant differences in LVEF or LAD were noticed over time. Regarding clinical outcomes at 18 months, overall mortality (M) was 24% (9P) and 51% (19P) died or were hospitalized due to heart failure (MH). No difference was found between groups: M (p= 0.119), MH (p= 0.091).

Conclusion
This study reports better LV reshape effects after MI in P with non-ischemic etiology, with sustained improvement over time. However, no differences regarding mortality or hospitalization due to HF were apparent at the 18-month FU. Larger long-term studies are required to evaluate these results.
Abstract Figure. LV remodelling pattern
Prognostic role of echocardiography to predict cardiovascular involvement in systemic sclerosis
Authors: Mazzola M , Bruni C , Pugliese NR , D"alto M , Argiento P , Moreo A , De Chiara B , Vriz O , Ferrara F , Bossone E , Matucci-Cerinic M , Gargani L 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.
Purpose. Cardiovascular involvement in systemic sclerosis (SSc) is frequent, often subtle, and is associated with poor prognosis. Our aim was to compare echocardiographic data of SSc patients to controls, and to assess parameters able to predict the development of cardiovascular involvement.
Methods. We enrolled 756 SSc patients (Group 1) without a previous diagnosis of cardiac involvement nor pulmonary arterial hypertension (PAH), and 614 healthy controls (Group 2) matched for age (Group 1 54.9 ± 14.6 years vs Group 2 54.4 ± 12.1, p = 0.6), sex (7.3% vs 7.2%, p = 0.8), and prevalence of hypertension (17.8% vs 19.8%, p = 0.2). All subjects underwent a comprehensive transthoracic 2D and Doppler echocardiography, including tissue Doppler imaging analysis (TDI). Five hundred and two SSc patients were followed-up and the development of PAH, left-sided heart failure (LHF), right-sided heart failure (RHF), and need of implantable cardioverter defibrillator (ICD) were considered as events.
Results. Compared to controls, SSc patients showed worse left and right ventricular systolic and diastolic function, hemodynamics and right ventricle-arterial coupling (tricuspid annulus plane systolic excursion over systolic pulmonary artery pressure, TAPSE/sPAP) (Table). After a median follow-up with of 35 moths, 45 composite events (PAH, LVH, RHF and ICD) occurred. In a multivariate model, only ejectioin fraction (EF) and TAPSE/sPAP had independent prognostic value (Table).
Conclusions. SSc patients without overt cardiovascular involvement and no PAH display subtle impairments in biventricular systo-diastolic function and right ventricle-arterial coupling. Left ventricular EF and TAPSE/sPAP can predict further cardiovascular events.
Descriptive analysis and Cox regression Descriptive Univariate Multivariate VARIABLE Group 1 (Ssc) n = 756 Group 2 (controls) n = 614 p HR (95 % CI) p HR (95% CI) p Ejection fraction (%) 63 ± 5.7 63.7 ± 5.9 0.038 0.94 (0.88 - 0.99) 0.024 0.91 (0.85 - 0.98) 0.017 E/A 1.0 ± 0.46 1.2 ± 0.51 &lt;0.0001 1.41 (0.77 - 2.58) 0.26 e’ mean (mm) 10.7 ± 3 11.2 ± 3.4 0.034 0.87 (0.76 - 0.99) 0.038 1.0 (0.87 - 1.17) 0.902 Left atrial volume index (mL/m2) 26.5 ± 7.7 21.3 ± 6.7 &lt;0.0001 1.03 (0.98 - 1.1) 0.24 TAPSE (mm) 22.1± 23.3± &lt;0.0001 0.89 (0.81 - 0.97) 0.012 sPAP (mmHg) 24.7± 22.3± &lt;0.0001 1.07 (1.04 - 1.1) &lt; 0.0001 TAPSE/sPAP (mm/mmHg) 0.98 ± 0.96 1.1 ± 0.39 &lt;0.0001 0.036 (0.009 - 0.141) &lt; 0.0001 0.03 (0.004 - 0.19) &lt; 0.0001 Pericardial effusion 57 (7.5%) 0 (0%) &lt;0.0001 1.10 (0.38 - 3.15 ) 0.85