bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of Primary Eyelid Lymphedema by Periorbital Lymphovenous Anastomosis: A Case Report
Authors: Cha Han Gyu , Hyun Dong Yun , Park Eun Soo , Choi Chang Yong , Nam Seung Min 
Published: December 2024

AbstractEyelid lymphedema is a rare condition that presents as persistent swelling and non-pitting edema of the eyelids. Treatment options for this disease are limited, including surgical debulking and medications, which do not achieve complete resolution. Few studies have demonstrated the use of lymphovenous anastomosis (LVA) in the preauricular area for eyelid lymphedema treatment. In this report, we demonstrate the successful treatment of primary eyelid lymphedema by performing multiple LVAs in the periorbital region, where dermal backflow was visualized using indocyanine green lymphography. A total of four LVAs were performed through two separate incisions at the lateral canthal area and lateral eyebrow in a patient with unilateral upper eyelid lymphedema that resulted in significant improvement without recurrence.
Assessing Pesticide Exposure and Regulatory Challenges in Malaysia: A Review of Population Monitoring, Food Residue, and Environmental Contamination
Authors: Waras Maisarah Nasution , How Vivien , Yahaya Noorfatimah , Shahrun Mohammad Shahid , Mohd Hijrah Nursyahidani Nadia , bin Sidek Ahmad Zulkhairul Naim , Amir Shah Ruddin Nurul Iffah , Abdul Rahaman Siti Rakiah 
Published: December 2024

AbstractPesticide applications do not always stay confined to their target. Human exposure to pesticides can lead to various health effects, such as cancer, reproductive toxicity, and neurodegenerative disorders. For that reason, stringent regulations govern pesticide registration and application before they enter the market. This objective of this article is to review studies conducted in Malaysia related to human biomonitoring and pesticide residue monitoring in the environment and food with the aim to explore the extent and pathway of pesticide exposure among the population, which indirectly allows us to examine the effectiveness of pesticide regulatory systems. Articles published from 2010 until 2024 from ScienceDirect, Scopus, and Google Scholar were explored. In Malaysia, biomonitoring of pesticide is conducted sporadically by independent researchers and does not provide a comprehensive understanding of the population's exposure through various routes of exposures. Additionally, the effectiveness of environmental regulatory measures remains unclear because of lack of monitoring data available publicly for interpretation. Moreover, dietary exposure assessments of pesticide residues in food are conducted randomly in Malaysia. This approach contrasts with other countries where the Total Diet Studies comprehensively evaluate the entire population's exposure to pesticide residues through dietary pathways. In summary, there is a need for a more comprehensive and systematic study of Malaysia's pesticide regulatory system specifically through biological, environmental, and food monitoring. Understanding the effectiveness of current regulations in controlling pesticide exposure is vital not only for public health but also for overall environmental well-being of the nation.
Sharp Recanalization of the Hepatic Vein Using a Chiba Needle in Budd–Chiari Syndrome
Authors: Patel Ranjan Kumar , Tripathy Taraprasad , Behera Srikant , Mohapatra Rakesh Kumar , Kumar Aditi 
Published: December 2024

AbstractHepatic vein recanalization in Budd–Chiari syndrome may require procedural modification if the endovascular approach fails. Sharp recanalization using the stiff end of a guidewire or a thin Chiba needle remains an effective technique in difficult-to-cross hepatic vein stricture. Of note, this technique requires utmost precaution to avoid catastrophic hemorrhage. The present case describes the successful recanalization of the middle hepatic vein using a 21-gauge Chiba needle through the percutaneous transhepatic route.
EGFR Mutation in Neonatal Nephrocutaneous Syndrome: Unveiling a Genetic Challenge
Authors: Lopes Manuela S. , Martins Cátia , Ferraz Ana , Rosmaninho-Salgado Joana , Castelo Rui , Tiago Joaquim , Ramos Leonor 
Published: December 2024

AbstractEpidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that exhibits tyrosine kinase signaling activity, playing a pivotal role in various cellular processes. Overexpression or overactivity of EGFR is significantly associated with inflammatory and malignant diseases, particularly lung cancer. Conversely, germline loss-of-function mutations in EGFR have been distinctly linked to a rare condition known as neonatal nephrocutaneous syndrome. We report a case of a preterm female neonate, born to consanguineous parents and from a pregnancy that was complicated by polyhydramnios. From birth, she displayed distinctive clinical features, including fragile skin and widespread erythema, sparse scalp hair, bilateral ankyloblepharon, thick eyebrows, and arachnodactyly. Subsequently, she developed progeroid features marked by skin desquamation, along with failure to thrive, diarrhea, and severe electrolyte and acid–base imbalances. Additional complications comprised anemia, generalized mucocutaneous candidiasis, external otitis, and recurrent septic episodes. Genetic analysis confirmed a homozygous EGFR mutation c.1283G > A p.(Gly428Asp). The infant's neurological status remained stable, albeit requiring pain management through oral morphine and gabapentin. Palliative care became imperative, given the dismal prognosis. The identified mutation is exceedingly rare, with only 24 reported cases known thus far. Each of these instances resulted in a complex multisystemic condition marked by a wide range of challenging symptoms and signs. This clinical journey highlights the intricate interplay among genetic mutations and complex medical conditions, and underscores the critical significance of multidisciplinary care.
Comorbidity of Cerebral Palsy and Bipolar Disorder in Two Adolescents: Case Series
Authors: Nas Ünver Ayda Beril , Onat Merve , Çöp Esra 
Published: December 2024

AbstractCerebral palsy (CP) is a common condition in children that affects movement and posture due to nonprogressive disruptions during cerebral development. Patients with CP are at a higher risk of developing mental health disorders due to social and physical factors. In total, 28 to 57% of children diagnosed with CP exhibit psychiatric diagnoses or symptoms. The symptoms of intellectual disability and related behavioral disorders that are often associated with CP can be easily confused with the symptoms of a mood disorder. Therefore, there is a possibility of a delay in the diagnostic procedure and the commencement of treatment, which could potentially endanger the mental health of the adolescent and result in long-term complications. By shedding light on diagnosis, treatment, and the follow-up process, this case series, which includes two adolescents with bipolar disorder and CP comorbidity, aims to contribute to the limited literature.
A Rare Case of Recurrent Disturbed Consciousness with Alternating Hemiplegia Associated with 46,XX,der(18)t(12;18)(p11.2;p11.2)
Authors: Kawamura Aoi , Yamaguchi Hiroshi , Hanafusa Hiroaki , Ito Tatsuhito , Kyono Yuki , Samejima Tomohiro , Oikawa Shizuka , Tokumoto Shoichi , Nozu Kandai , Nagase Hiroaki 
Published: December 2024

AbstractTrisomy of the short arm of chromosome 12 (trisomy 12p) is a rare chromosomal abnormality causing dysmorphic features, congenital anomalies, intellectual disabilities, developmental delays, and seizures. Detailed information regarding the types of seizures is scarce owing to the low incidence of seizures. In contrast, 18p deletions and seizures are rare. Previous reports on trisomy 12p or monosomy 18p are limited, and little is known about epilepsy in children with trisomy 12p or monosomy 18p. Here, we report a case of 46,XX,der(18)t(12;18)(p11.2;p11.2) with repeatedly disturbed consciousness accompanied by alternating hemiplegia, corresponding to the electroencephalogram findings. G-banding of the parents showed balanced translocation of the mother. The last hospitalization occurred when the patient was 12 years old and presented with disturbed consciousness and left-sided hemiplegia. Electroencephalogram showed continuous 1 to 2 Hz slow waves in the right hemisphere and a theta burst in the left hemisphere. Based on the genes on chromosomes 12 and 18, the symptoms seemed to be related to partial trisomy 12p. Our case suggests the possibility of a novel seizure phenotype associated with trisomy 12p.
The politics of the textbook, revisited
Authors: Wilson Tina E 
Published: December 2024

Abstract
Social work evolves over time as political states, social movements, and helping professions renegotiate definitions of a good or adequate life and how it can be achieved. This article uses a conjunctural analysis approach to consider the changing role of social work in Canada. A comparative qualitative content analysis of commonly assigned introductory textbooks was conducted, focusing on the overall historical narrative and scope of practice, as well as evolving justice topics. The findings indicate significant shifts from an earlier focus on state protection from capitalism to more detailed, equity-focused quality of life frameworks. Additionally, three significant pressures on broader justice perspectives were identified: (1) the ongoing reworking of and engagement with lived experience, (2) the unique status of Indigenous peoples, and (3) emerging attention to the natural environment. The study also considers contradictions within and among these domains. Further research into the changing scope of social work and the meaning of pivotal keywords like social progress and social justice in specific state contexts is recommended.
Standing at the crossroads: Child safeguarding and Deaf BSL parents (in England)—Issues and challenges in social work
Authors: Oram Rosemary , Young Alys , Cartney Patricia 
Published: December 2024

Abstract
Focussing on Deaf parents using British Sign Language (BSL) in England, this article shares perspectives of Child and Family social work practitioners (CFSWs) across a large urban area, through the lens of cultural competence. In an under-researched field, it explores linguistic and cultural aspects of working with Deaf parents, for whom English is not their first language, in the specific context of parenting assessments in child safeguarding procedures. Individual semi-structured online interviews were conducted by the researcher (in BSL) with seven CFSWs using English, involving a sign language interpreter. Participants were encouraged to reflect on the assessment process when it involves Deaf parents and/or other cultural-linguistic minority groups. Employing Braun and Clarke’s reflective thematic analysis method, the findings are grouped into three themes: CFSWs’ knowledge of working with Deaf people; cultural aspects relating to Deaf parents’ understanding of safeguarding/child protection proceedings; and meeting the communication and cultural needs of Deaf parents. The results identify several factors in current practice which impact CFSWs’ competence to carry out an assessment involving a Deaf BSL parent. Findings highlight the need for relevant training and resources developed specifically for this cultural minority group. Future research including the direct perspectives of Deaf parents is indicated.
Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast
Authors: Thomas Pınar B , Kaluç Nur , Çavlı Irmak N , Tuna Bilge G 
Published: December 2024

Abstract
Chronological lifespan (CLS) in budding yeast Saccharomyces cerevisiae, which is defined as the time nondividing cells in saturation remain viable, has been utilized as a model to study post-mitotic aging in mammalian cells. CLS is closely related to entry into and maintenance of a quiescent state. Many rearrangements that direct the quiescent state enhance the ability of cells to endure several types of stress. Small ubiquitin-like modifier (SUMO)-targeted ubiquitin ligases (STUbLs) play a critical role in mediating an adaptive response to various stresses. In this study, we investigated the effect of a STUbL, Slx5/Slx8, on CLS in budding yeast. We showed that both SLX5 and SLX8 deletions accelerate chronological aging, resulting in a decreased maximum and mean lifespan. slx5Δ cells were capable of entering or maintaining a quiescent state during aging. On the other hand, aging slx5Δ and slx8Δ cells had both increased spontaneous mutation accumulation. Our data together indicate that Slx5/Slx8 STUbL is required for normal rate of aging by preventing increased spontaneous mutation accumulation during aging.
Uncovering novel therapeutic clues for hypercoagulable active ulcerative colitis: novel findings from old data
Authors: Yu Zhexuan , Zhao Danya , Zhang Yusen , Shen Kezhan , Shao Shisi , Chen Xiaobo , Shu Jianlong , Li Guanhua 
Published: December 2024

Abstract

Background
Hypercoagulability has been shown to act as an important component of ulcerative colitis (UC) pathogenesis and disease activity, and is strongly correlated with the occurrence of venous thromboembolism (VTE). This study aimed at providing novel therapeutic clues for hypercoagulable active UC.

Methods
The coagulation score model was developed using VTE cohorts, and the predictive performance of this model was evaluated by coagulation subtypes of UC patients, which were clustered by the unsupervised method. Subsequently, the response of UC of distinct coagulation types, as identified by the coagulation scoring model, to different biological agents was evaluated. Immunoinflammatory cells and molecules that were associated with hypercoagulable active UC were explored by employing gene set variation analysis, single-sample gene set enrichment analysis, univariate logistic regression analysis, and immunohistochemistry.

Results
A coagulation scoring model was established, which includes five key coagulation factors (ARHGAP35, CD46, BTK, C1QB, and F2R), and accurately distinguished the coagulation subtypes of UC. When comparing anti-TNF-α agents with other biological agents after determining the model, especially golimumab, it showed more effective treatment for hypercoagulable active UC. CXCL8 has been identified as playing an important role in the tightly interconnected network between the immune-inflammatory system and coagulation system in UC. Immunohistochemical analysis showed that the expression of CXCL8, BTK, C1QB, and F2R was upregulated in active UC.

Conclusions
Anti-TNF-α agents have significant therapeutic effects on hypercoagulable active UC, and the strong association between CXCL8, hypercoagulation, and disease activity provides a novel therapeutic insight into hypercoagulable active UC.
Young Adult Caregivers for Older Family Members: Setting a New Research Agenda
Authors: Fingerman Karen L , Zhou Zexi , Haley William E , Zarit Steven H 
Published: December 2024

Abstract
Young adults (approximately aged 18 to 29) are frequently involved in caring for older relatives, potentially filling gaps and playing key roles in the network of caregivers. The time is ripe to synthesize the emerging literature on this topic and propose an agenda for future research. This paper identifies key questions for research that will propel the field forward, including: a) Why young adult caregiving warrants distinct consideration from caregiving in midlife or later life, b) Young adult caregivers’ position in the caregiving network and tasks they perform, c) Factors that help determine who becomes a caregiver at this stage of life and who does not, with attention to race/ethnicity, and beliefs about family interdependency. We then address appraisals of caregiving stress and rewards, and potential factors that may buffer the negative impact of caregiving at this stage of life. We extend this discussion to the detriments and benefits of caregiving for well-being. We consider longer-term enduring positive and negative consequences of caregiving at this potentially transformative stage of adulthood. Throughout this paper, we review many of the founding studies and scholars who have laid the groundwork in this emerging field and point out the components of existing models of caregiving that particularly apply to young adult caregivers. We conclude with suggestions for potential policies and programs to allow for young adults to engage in caregiving while also pursuing the roles and activities that align with their values and set them up for a successful adulthood.
The Effect of Wing-Flashing Behavior on Prey Capture Performance of San Clemente Loggerhead Shrikes
Authors: Mora Y A , Sheldon S , Carrero J , Farabaugh S M , Sustaita D 
Published: December 2024

Synopsis
Loggerhead shrikes (Lanius ludovicianus) are medium-sized predatory songbirds that feed on arthropods and vertebrates. Prior to attacking their prey, shrikes have been observed performing “wing-flashing” behavior, consisting of rapid fluttering of the wings that seems to emphasize the white patches on their dorsal surfaces. We sought to quantify this behavior by analyzing videos of San Clemente loggerhead shrikes attacking insect and vertebrate prey, to understand whether and how wing-flashing affects prey capture performance. We measured predictors of wing-flashing behavior, wing-flashing kinematics, and prey capture performance in terms of the number of strikes required to kill prey, prey strike durations, prey escape distances, and prey survival probabilities. Juveniles were more likely to perform wing-flashing behavior than adults, and lizards elicited wing-flashing more than mice and crickets. Adult males tended to flash their wings faster than juvenile males, and although wing-flashing rates were similar between ages for females and across prey types (∼15 Hz), shrikes flashed their wings for longer durations toward lizards. Wing-flashing was generally associated with fewer strikes to kill prey and resulted in longer prey strike durations for adult shrikes, longer prey escape distances, and lower prey survival probabilities for male shrikes. Our results suggest that wing-flashing behavior of loggerhead shrikes enhances their prey capture performance, possibly by stimulating prey to move—and not to move, depending on prey type—making them more vulnerable to predatory strikes.
Myxobacteria from soil can substantially reduce the bacterial load in a wound infection model
Authors: Arakal Benita S , Rowlands Richard S , Maddocks Sarah E , Whitworth David E , James Philip E , Livingstone Paul G 
Published: December 2024

Abstract

Aims
Myxobacteria are non-pathogenic, saprophytic, soil-dwelling predatory bacteria known for their antimicrobial potential. Many pathogenic bacteria form biofilms to protect themselves from antimicrobial agents and the immune system. This study has investigated the predatory activities of myxobacteria against pathogenic bacteria in biofilms.

Methods and results
A total of 50 soil samples were collected in and around Cardiff, South Wales (UK). Using a baiting method with 6 prey organisms, 32 myxobacteria were isolated and identified by 16S rRNA sequencing, of which 18 were Myxococcus spp. and 14 were Corallococcus spp. Predation assays, biofilm inhibition and disruption assays, and a dynamic, polymicrobial wound biofilm model were used with live myxobacteria to assess efficacy of predation. Good activity in predation assays was observed against Escherichia coli, while Enterococcus faecalis was more recalcitrant to myxobacteria. Staphylococcus aureus and Citrobacter freundii were significantly (P &lt; 0.05) reduced in both biofilm inhibition and disruption assays compared to other pathogens. Considerable reductions (&gt;3 log10 CFU) in the wound infection model were seen after 96 h of incubation, particularly for C. freundii and E. coli.

Conclusion
Using live predatory bacteria as an alternative therapeutic agent has received attention in the recent past to combat the problem of antimicrobial resistance. Myxobacteria isolated from soil using multiple prey organisms yielded diverse isolates, including strains which exhibited therapeutically promising activities in a variety of infection/biofilm assays.
Individuals with heterogenous trabecular bone texture by clinical magnetic resonance imaging have lower bone strength and stiffness by quantitative computed tomography-based finite element analysis
Authors: Dash Alexander S , Breighner Ryan , Gonzalez Fernando Quevedo , Blumberg Olivia , Koff Matthew F , Billings Emma , Heilbronner Alison , Nieves Jeri , Stein Emily M 
Published: December 2024

Abstract
Opportunistic screening is essential to improve the identification of individuals with osteoporosis. Our group has utilized image texture features to assess bone quality using clinical MRIs. We have previously demonstrated that greater heterogeneity of MRI texture related to history of fragility fractures, lower bone density, and worse microarchitecture. The present study investigated relationships between MRI-based texture features and biomechanical properties of bone using CT-based finite element analyses (FEAs). We hypothesized that individuals with greater texture heterogeneity would have lower stiffness and failure load. Thirty individuals included in this prospective study had CT and MRI of L1 and L2 vertebrae. Using T1-weighted MR images, a gray-level co-occurrence matrix was generated to characterize the distribution and spatial organization of voxelar signal intensities to derive the following texture features: contrast (variability), entropy (disorder), angular second moment (ASM; uniformity), and inverse difference moment (IDM; homogeneity). Features were calculated in five directions relative to the image plane. Whole-bone stiffness and failure load were calculated from phantom-calibrated lumbar QCT. Mean age of subjects was 59 ± 11 yr (57% female). Individuals with lower vertebral stiffness had greater texture heterogeneity; specifically, higher contrast (r = −0.54, p &lt; .01), higher entropy (r = −0.52, p &lt; .01), lower IDM (r = 0.54, p &lt; .01) and lower ASM (r = 0.51, p &lt; .01). Lower vertebral failure load and lower vBMD were similarly associated with greater texture heterogeneity. Relationships were unchanged when using the average of texture in all directions or the vertical direction in isolation. In summary, individuals with more heterogeneous MRI-based trabecular texture had lower stiffness and failure load by FEA, and lower vBMD by central quantitative CT. These results—the first relating MRI-based texture features and biomechanical properties of bone—provide further support that MRI-based texture measurements can be used to opportunistically detect skeletal fragility.