bluuebunny/crossref_metadata_2025_split huggingface dataset:
Helicobacter pylori and gastric cancer: a lysosomal protease perspective
Authors: Soond Surinder M. , Zamyatnin Andrey A. 
Published: December 2021

AbstractThe intimate involvement of pathogens with the heightened risk for developing certain cancers is an area of research that has captured a great deal of attention over the last 10 years. One firmly established paradigm that highlights this aspect of disease progression is in the instance ofHelicobacter pyloriinfection and the contribution it makes in elevating the risk for developing gastric cancer. Whilst the molecular mechanisms that pinpoint the contribution that this microorganism inflicts towards host cells during gastric cancer initiation have come into greater focus, another picture that has also emerged is one that implicates the host’s immune system, and the chronic inflammation that can arise therefrom, as being a central contributory factor in disease progression. Consequently, when taken with the underlying role that the extracellular matrix plays in the development of most cancers, and how this dynamic can be modulated by proteases expressed from the tumor or inflammatory cells, a complex and detailed relationship shared between the individual cellular components and their surroundings is coming into focus. In this review article, we draw attention to the emerging role played by the cathepsin proteases in modulating the stage-specific progression ofHelicobacter pylori-initiated gastric cancer and the underlying immune response, while highlighting the therapeutic significance of this dynamic and how it may be amenable for novel intervention strategies within a basic research or clinical setting.
Stimulated Raman histology in the neurosurgical workflow of a major European neurosurgical center — part A
Authors: Neidert Nicolas , Straehle Jakob , Erny Daniel , Sacalean Vlad , El Rahal Amir , Steybe David , Schmelzeisen Rainer , Vlachos Andreas , Reinacher Peter Christoph , Coenen Volker Arnd , Mizaikoff Boris , Heiland Dieter Henrik , Prinz Marco , Beck Jürgen , Schnell Oliver 
Published: December 2021

AbstractHistopathological diagnosis is the current standard for the classification of brain and spine tumors. Raman spectroscopy has been reported to allow fast and easy intraoperative tissue analysis. Here, we report data on the intraoperative implementation of a stimulated Raman histology (SRH) as an innovative strategy offering intraoperative near real-time histopathological analysis. A total of 429 SRH images from 108 patients were generated and analyzed by using a Raman imaging system (Invenio Imaging Inc.). We aimed at establishing a dedicated workflow for SRH serving as an intraoperative diagnostic, research, and quality control tool in the neurosurgical operating room (OR). First experiences with this novel imaging modality were reported and analyzed suggesting process optimization regarding tissue collection, preparation, and imaging. The Raman imaging system was rapidly integrated into the surgical workflow of a large neurosurgical center. Within a few minutes of connecting the device, the first high-quality images could be acquired in a “plug-and-play” manner. We did not encounter relevant obstacles and the learning curve was steep. However, certain prerequisites regarding quality and acquisition of tissue samples, data processing and interpretation, and high throughput adaptions must be considered. Intraoperative SRH can easily be integrated into the workflow of neurosurgical tumor resection. Considering few process optimizations that can be implemented rapidly, high-quality images can be obtained near real time. Hence, we propose SRH as a complementary tool for the diagnosis of tumor entity, analysis of tumor infiltration zones, online quality and safety control and as a research tool in the neurosurgical OR.
Lessons from the Japanese ninja: on achieving a higher trade equilibrium under anarchy and private constitutions
Authors: Maltsev Vladimir V. 
Published: December 2021

AbstractThis paper investigates the possibility of anarchy achieving a high trade equilibrium via the example of ninja communities in Japan. Initially, ninjas in the mountainous regions of Iga and Kōka were stateless, constantly feuded, and had few opportunities for exchange. With the advent of civil war in the sixteenth century, ninjas’ economic conditions changed. The mercenary market significantly expanded and presented great profit opportunities for the ninjas. However, instead of creating a formal government to move to a higher trade equilibrium, the ninjas resorted to forming voluntary confederations held together by private constitutions. I argue that this development was possible because the institutional environment of the Sengoku period enabled a framework of self-governing institutions and principles. The ninjas were able to build on this framework with very low organizational costs. As a result, the ninjas were able to reap large economic gains on the mercenary market while remaining stateless—a seemingly paradoxical development that goes against the standard dichotomy of “states and thick markets” versus “anarchy and thin markets.”
Buoyancy-driven algebraic (localised) boundary-layer disturbances
Authors: Edwards S. M. , Hewitt R. E. 
Published: December 2021

AbstractWe show that a new class of steady linear eigenmodes exist in the Falkner–Skan boundary layer, associated with an algebraically developing, thermally coupled three-dimensional perturbation that remains localised in the spanwise direction. The dominant mode has a weak temperature difference that decays (algebraically) downstream, but remains sufficient (for favourable pressure gradients that are below a critical level) to drive an algebraically growing disturbance in the velocity field. We determine the critical Prandtl number and pressure gradient parameter required for downstream algebraic growth. We also march the nonlinear boundary-region equations downstream, to demonstrate that growth of these modes eventually gives rise to streak-like structures of order-one aspect ratio in the cross-sectional plane. Furthermore, this downstream flow can ultimately become unstable to a two-dimensional Rayleigh instability at finite amplitudes.
Adversarial Attack for Uncertainty Estimation: Identifying Critical Regions in Neural Networks
Authors: Alarab Ismail , Prakoonwit Simant 
Published: December 2021

AbstractWe propose a novel method to capture data points near decision boundary in neural network that are often referred to a specific type of uncertainty. In our approach, we sought to perform uncertainty estimation based on the idea of adversarial attack method. In this paper, uncertainty estimates are derived from the input perturbations, unlike previous studies that provide perturbations on the model's parameters as in Bayesian approach. We are able to produce uncertainty with couple of perturbations on the inputs. Interestingly, we apply the proposed method to datasets derived from blockchain. We compare the performance of model uncertainty with the most recent uncertainty methods. We show that the proposed method has revealed a significant outperformance over other methods and provided less risk to capture model uncertainty in machine learning.
Is Religion a Determinant of Financial Development?
Authors: Amissah Emmanuel , Świerczyńska Katarzyna 
Published: December 2021

AbstractStudies on the determinants of financial development have been silent on the role of religion. Growing evidence in the literature about how financial development positively affects economic growth and development highlights a greater interest in understanding the determinants of financial development. Despite the growing interest in this direction, less focus has been given to the role of religion in financial development. Using data from the World Values Survey, this study explores the relationship between finance and religion. In this study, finance is modelled through different measures of financial development and religion is represented by the intensity of religiosity. Results showed that on average there is a significant negative relationship. Subsequent analysis showed that as countries become financially developed, this negative relationship becomes insignificant. The quantile regression technique was employed to capture the nature of the relationship at different levels. The analysis showed that as countries become financially developed, the negative relationship becomes insignificant to financial development. These results account for some of the differences in the level of financial development between developed and developing countries where the latter tend to be more religious than the former.
The Impact of the COVID-19 Pandemic on Mental Health, Occupational Functioning, and Professional Retention Among Health Care Workers and First Responders
Authors: Hendrickson Rebecca C. , Slevin Roisín A. , Hoerster Katherine D. , Chang Bernard P. , Sano Ellen , McCall Catherine A. , Monty Gillian R. , Thomas Ronald G. , Raskind Murray A. 
Published: December 2021

Abstract
Background
The COVID-19 pandemic has greatly affected front-line health care workers (HCW) and first responders (FR). The specific components of COVID-19 related occupational stressors (CROS) associated with psychiatric symptoms and reduced occupational functioning or retention remain poorly understood.

Objectives
Examine the relationships between total and factored CROS, psychiatric symptoms, and occupational outcomes.

Design
Observational, self-report, single time-point online assessment.

Participants
A total of 510 US HCW (N = 301) and FR (N = 200) with occupational duties affected by the COVID-19 pandemic.

Main Outcomes and Measures
CROS were assessed using a custom 17-item questionnaire. Post-traumatic stress disorder (PTSD), depression, insomnia, and generalized anxiety symptoms were assessed using the PTSD Checklist-5 (PCL5), Patient Health Questionnaire-9 (PHQ9), Insomnia Severity Index (ISI), and General Anxiety Disorder-7 (GAD7). Respondents’ likelihood of leaving current field and occupational functioning were assessed with 2-item PROMIS subscales. Relationships were modeled using multivariable regression. Open-ended responses were coded using rapid template analysis.

Results
CROS total scores correlated significantly with all four psychiatric symptom domains (R’s = .42–.53), likelihood of leaving one’s current occupation (R = .18), and trouble doing usual work (R = .28), all p’s < .001. Half of HCW indicated a decreased likelihood of staying in their current occupation as a result of the pandemic. CROS were fit to a 3-factor model consisting of risk, demoralization, and volume factors. All CROS factors were associated with psychiatric symptom burden, but demoralization was most prominently associated with psychiatric symptoms and negative occupational outcomes. Among psychiatric symptoms, PTSD symptoms were most strongly associated with negative occupational outcomes. Open-ended statements emphasized lack of protection and support, increased occupational demands, and emotional impact of work duties.

Conclusions and Relevance
These results demonstrate potentially treatable psychiatric symptoms in HCW and FR experiencing CROS, impacting both wellbeing and the health care system. Mitigating CROS, particularly by addressing factors driving demoralization, may improve HCW and FR mental health, occupational functioning, and retention.
Task scheduling for transport and pick robots in logistics: a comparative study on constructive heuristics
Authors: Wang Hanfu , Chen Weidong 
Published: December 2021

AbstractWe study the Transport and Pick Robots Task Scheduling (TPS) problem, in which two teams of specialized robots, transport robots and pick robots, collaborate to execute multi-station order fulfillment tasks in logistic environments. The objective is to plan a collective time-extended task schedule with the minimization of makespan. However, for this recently formulated problem, it is still unclear how to obtain satisfying results efficiently. In this research, we design several constructive heuristics to solve this problem based on the introduced sequence models. Theoretically, we give time complexity analysis or feasibility guarantees of these heuristics; empirically, we evaluate the makespan performance criteria and computation time on designed dataset. Computational results demonstrate that coupled append heuristic works better for the most cases within reasonable computation time. Coupled heuristics work better than decoupled heuristics prominently on instances with relative few pick robot numbers and large work zones. The law of diminishing marginal utility is also observed concerning the overall system performance and different transport-pick robot numbers.
Constrained Citizens? Ideological Structure and Conflict Extension in the US Electorate, 1980–2016
Authors: Hare Christopher 
Published: December 2021

AbstractPast the half-century mark of Converse's (1964) field-defining essay, the nature of political ideology in the mass public and how it has changed in response to partisan polarization remains enigmatic. To test the ideological structure of US public opinion, I develop and implement a Bayesian dynamic ordinal item response theory model. In contrast to static scaling procedures, this method allows for changes in the mappings between issue attitudes and the underlying ideological dimension over time. The results indicate that over the last forty years, mass attitudes on a range of long-standing policy controversies better fit a unidimensional ideological structure. As among elites, the left–right dimension has come to encompass a wide range of policy, partisan, and value divides in the mass public. Further, these trends hold for voters at all levels of political sophistication. Widespread conflict extension appears to be a defining feature of mass polarization in contemporary US politics.
Gendered retirement pathways across lifecourse regimes
Authors: Madero-Cabib Ignacio , Le Feuvre Nicky , König Stefanie 
Published: December 2021

AbstractIn order to capture the rapidly changing reality of older workers, it is important to study retirement not as a one-off transition, but rather as a series of diverse pathways that unfold during the period before and after reaching the full retirement age. The retirement transitions of men and women have been shown to vary widely according to individual characteristics such as health, education and marital status, but also according to macro-institutional factors, such as welfare regimes and gender norms. While there is a consensus about the combined influence of institutional and individual factors in shaping retirement transitions, previous research has rarely included both levels of analysis. This study aims to close this research gap. Using a pooled-country dataset from three panel surveys, covering 11 nations, we examine the retirement pathways of 1,594 women and 1,105 men during a 12-year period (2004–2016) around the country- and gender-specific full pension age. Results show that retirement pathways diverge considerably across countries and lifecourse regimes. The distribution of men and women between the different pathways is also variable, both within and across societal contexts. More importantly, the influence of individual-level characteristics, such as education, on the gendering of retirement pathways is not identical across societal contexts. These findings provide useful insights into the gender-differentiated implications of policies aimed at extending working lives.
‘You really do become invisible’: examining older adults’ right to the city in the United Kingdom
Authors: Menezes Deborah , Woolrych Ryan , Sixsmith Judith , Makita Meiko , Smith Harry , Fisher Jenny , Garcia-Ferrari Soledad , Lawthom Rebecca , Henderson James , Murray Michael 
Published: December 2021

AbstractA global ageing population presents opportunities and challenges to designing urban environments that support ageing in place. The World Health Organization's Global Age-Friendly Cities movement has identified the need to develop communities that optimise health, participation and security in order to enhance quality of life as people age. Ensuring that age-friendly urban environments create the conditions for active ageing requires cities and communities to support older adults’ rights to access and move around the city (‘appropriation’) and for them to be actively involved in the transformation (‘making and remaking’) of the city. These opportunities raise important questions: What are older adults’ everyday experiences in exercising their rights to the city? What are the challenges and opportunities in supporting a rights to the city approach? How can the delivery of age-friendly cities support rights to the city for older adults? This paper aims to respond to these questions by examining the lived experiences of older adults across three cities and nine neighbourhoods in the United Kingdom. Drawing on 104 semi-structured interviews with older adults between the ages of 51 and 94, the discussion centres on the themes of: right to use urban space; respect and visibility; and the right to participate in planning and decision-making. These themes are illustrated as areas in which older adults’ rights to access and shape urban environments need to be addressed, along with recommendations for age-friendly cities that support a rights-based approach.
Impacts of biophilic design on the development of gerotranscendence and the Profile of Mood States during the COVID-19 pandemic
Authors: Afacan Yasemin 
Published: December 2021

AbstractTo live in a good mood is not only a key consideration for future age-friendly communities, but also a critical necessity for positive ageing. Despite growing evidence of correlations between contact with nature and stress reduction, little is known about the effect of nature integration in indoor environments. Thus, this study aimed to answer the following research questions: (a) How do biophilic characteristics of home environments correlate with older adults’ experience of the multiple levels of the theory of gerotranscendence? and (b) What is the relationship between these experiences and the mood states of these older adults? The study was based on a comparative analysis to scrutinise the impact of the COVID-19 pandemic on these questions. The data were gathered through questionnaires with 450 older adults aged between 65 and 95 years, and stratified by the biophilic characteristics of their living environments: indoor biophilic, outdoor biophilic and non-biophilic. Two sets of data were collected with the same participants, respectively, before the COVID-19 pandemic (June to October 2018) and during the COVID-19 pandemic (June to October 2020). It found that the biophilic characteristics of home environments are correlated dynamically with older adults’ ageing experience and mood states. The study indicates that outdoor biophilic features facilitate the recovery of tension mood effects of the COVID-19 pandemic, whereas indoor biophilic features facilitate recovery from depression and anger.
Breakfast skipping and cognitive and emotional engagement at school: a cross-sectional population-level study
Authors: Moller Hero , Sincovich Alanna , Gregory Tess , Smithers Lisa 
Published: December 2021

AbstractObjective:Research on the consequences of breakfast skipping among students tends to focus on academic outcomes, rather than student well-being or engagement at school. This study investigated the association between breakfast skipping and cognitive and emotional aspects of school engagement.Design:Cross-sectional study using data from a population-level survey of children and adolescents’ well-being and engagement at school. Linear regression with adjustment for confounders was used to estimate the effect of breakfast skipping on school engagement.Setting:Government schools (i.e. public schools) in South Australia.Participants:The participants were students, Grades 4–12, who completed the Wellbeing and Engagement Collection in 2019. The analysis sample included 61 825 students.Results:Approximately 9·6 % of students reported always skipping breakfast, with 35·4 % sometimes skipping and 55·0 % never skipping. In the adjusted linear regression models, children and adolescents who always skipped breakfast reported lower levels of cognitive engagement (β = −0·26 (95 % CI −0·29, −0·25)), engagement with teachers (β = −0·17 (95 % CI −0·18, −0·15)) and school climate (β = −0·17 (95 % CI −0·19, −0·15)) compared with those who never skipped breakfast, after controlling for age, gender, health, sleep, sadness and worries, parental education, socio-economic status and geographical remoteness.Conclusion:Consistent with our hypothesis, skipping breakfast was associated with lower cognitive and emotional engagement, which could be due to mechanisms such as short-term energy supply and long-term health impacts. Therefore, decreasing the prevalence of breakfast skipping could have a positive impact on school engagement.
Properties of Electron Distributions in the Martian Space Environment
Authors: Andreone G. , Halekas J. S. , Mitchell D. L. , Mazelle C. , Gruesbeck J. 
Published: December 2021

AbstractElectron and magnetic field measurements from the Mars atmosphere and volatile environment (MAVEN) mission are utilized to study the interaction between Mars and the solar wind. Instruments like the solar wind electron analyzer (SWEA) aboard MAVEN measure properties of the electron environment over a broad range of electron energies. Measurements at low electron energies include contributions from spacecraft photoelectrons and secondary electrons that must be accounted for to accurately characterize the environment. We developed an algorithm to identify and remove secondary electron contamination to improve estimates of electron densities and temperature. We then compiled global maps of average electron density, temperature, and temperature anisotropy under different conditions, considering quasi‐parallel and quasi‐perpendicular bow shocks and upstream solar wind Alfven Mach number. Higher temperature anisotropy is observed for quasi‐perpendicular shock crossings, as expected. We find significant electron temperature anisotropy upstream of the bow shock for quasi‐perpendicular shock crossings, suggesting a heating mechanism, such as that provided by electromagnetic waves. We analyzed the influence of hi and low Alfven Mach number conditions and found the electron plasma beta to be the only electron property significantly affected. We studied the relationship between the electron distribution function and the generation of instabilities and conclude that the upstream Alfven Mach number influences the stability of electron distributions in the Martian environment.