bluuebunny/crossref_metadata_2025_split huggingface dataset:
Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats
Authors: Jiao Bin , Wang Mengli , Feng Hao , Bao Han , Zhang Feiran , Wu Hao , Wang Junling , Tang Beisha , Jin Peng , Shen Lu 
Published: March 2021

Abstract
GGGGCC repeats in a non-coding region of the C9orf72 gene have been identified as a major genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We previously showed that the GGGGCC expanded repeats alone were sufficient to cause neurodegeneration in Drosophila. Recent evidence indicates that GGGGCC expanded repeats can modify various gene transcriptomes. To determine the role of these genes in GGGGCC-mediated neurotoxicity, we screened an established Drosophila model expressing GGGGCC expanded repeats in this study. Our results showed that knockdown of the DNA topoisomerase II (Top2) gene can specifically modulate GGGGCC-associated neurodegeneration of the eye. Furthermore, chemical inhibition of Top2 or siRNA-induced Top2 downregulation could alleviate the GGGGCC-mediated neurotoxicity in Drosophila assessed by eye neurodegeneration and locomotion impairment. By contrast, upregulated Top2 levels were detected in Drosophila strains, and moreover, TOP2A level was also upregulated in Neuro-2a cells expressing GGGGCC expanded repeats, as well as in the brains of Sod1G93A model mice. This indicated that elevated levels of TOP2A may be involved in a pathway common to the pathophysiology of distinct ALS forms. Moreover, through RNA-sequencing, a total of 67 genes, involved in the pathways of intracellular signaling cascades, peripheral nervous system development, and others, were identified as potential targets of TOP2A to modulate GGGGCC-mediated neurodegeneration.
A global approach to addressing the policy, research and social challenges of male reproductive health
Authors: Barratt Christopher L R , De Jonge Christopher J , Anderson Richard A , Eisenberg Michael L , Garrido Nicolás , Rautakallio Hokkanen Satu , Krausz Csilla , Kimmins Sarah , O’Bryan Moira K , Pacey Allan A , Tüttelmann Frank , Veltman Joris A 
Published: March 2021

Abstract
Male infertility is a global health issue; yet to a large extent, our knowledge of its causes, impact and consequence is largely unknown. Recent data indicate that infertile men have an increased risk of somatic disorders such as cancer and die younger compared to fertile men. Moreover, several studies point to a significant adverse effect on the health of the offspring. From the startling lack of progress in male contraception combined with the paucity of improvements in the diagnosis of male infertility, we conclude there is a crisis in male reproductive health. The Male Reproductive Health Initiative has been organized to directly address these issues (www.eshre.eu/Specialty-groups/Special-Interest-Groups/Andrology/MRHI). The Working Group will formulate an evidence-based strategic road map outlining the ways forward. This is an open consortium desiring to engage with all stakeholders and governments.
New insight into trophic niche partitioning and diet of mackerel (Scomber scombrus) and herring (Clupea harengus) in Icelandic waters
Authors: Kvaavik Cecilia , Óskarsson Gudmundur J , Pétursdóttir Hildur , Marteinsdóttir Gudrun , Daníelsdóttir Anna Kristín 
Published: March 2021

AbstractUnderstanding the competitive interactions of ecological similar species is essential to determine their role and niche in the ecosystem. Using both conventional dietary methods and stable isotope analysis, we examined the feeding ecology, trophic position and possible niche partitioning of Northeast Atlantic mackerel (Scomber scombrus), Icelandic summer spawning (ISS) herring (Clupea harengus), and Norwegian spring spawning (NSS) herring from Icelandic waters during the spring and summer 2012 and 2014. The stomach analysis showed differences in prey preferences among the species during summer, where mackerel diets were almost exclusively calanoid copepods, while herring ate larger zooplankton, i.e. euphausiids and amphipods. Analysis of isotopic diet contribution of mackerel and herring using Bayesian mixing models, representing mainly the spring consumption, revealed that euphausiids were the main dietary contributor of both mackerel and herring. Fish prey were also an important dietary source for ISS herring, and amphipods were important to the diet of NSS herring. In addition, mackerel encompassed a broad isotopic niche, whereas the two herring stocks had narrower and separated niches from each other. The results from this analysis reveal new and holistic information into the diet of these species, which have various ecological implications.
Grandmothers’ endocrine disruption during pregnancy, low birth weight, and preterm birth in third generation
Authors: Yim Gyeyoon , Roberts Andrea , Wypij David , Kioumourtzoglou Marianthi-Anna , Weisskopf Marc G 
Published: March 2021

Abstract

Background
Diethylstilbestrol (DES) is an endocrine-disrupting pharmaceutical prescribed to pregnant women to prevent pregnancy complications between the 1940s and 1970s. Although DES has been shown in animal studies to have multigenerational effects, only two studies have investigated potential multigenerational effects in humans on preterm birth (PTB), and none on low birthweight (LBW)—major determinants of later life health.

Methods
Nurses’ Health Study (NHS) II participants (G1; born 1946–64) reported their mothers’ (G0) use of DES while pregnant with them. We used cluster-weighted generalized estimating equations to estimate odds ratios (OR) and 95% confidence intervals (CI) for risk of LBW and PTB among the grandchildren by grandmother use of DES. G1 birthweight and gestational age were considered to explore confounding by indication.

Results
Among 54 334 G0-G1/grandmother-mother pairs, 973 (1.8%) G0 used DES during pregnancy with G1. Of the 128 275 G2 children, 4369 (3.4%) were LBW and 7976 (6.2%) premature. Grandmother (G0) use of DES during pregnancy was associated with an increased risk of G2 LBW [adjusted OR (aOR) = 3.09; 95% CI: 2.57, 3.72], that was reduced when restricted to term births (aOR = 1.59; 95% CI: 1.08, 2.36). The aOR for PTB was 2.88 (95% CI: 2.46, 3.37). Results were essentially unchanged when G1 birthweight and gestational age were included in the model, as well as after adjusting for other potential intermediate variables, such as G2 pregnancy-related factors.

Conclusions
Grandmother use of DES during pregnancy is associated with an increased risk of LBW, predominantly through an increased risk of PTB. Results when considering G1 birth outcomes suggest this does not result from confounding by indication.
Biological Control ofAphis spiraecola(Hemiptera: Aphididae) Using Three Different Flowering Plants in Apple Orchards
Authors: Cai Zhiping , Ouyang Fang , Zhang Xingrui , Chen Jing , Xiao Yunli , Ge Feng , Zhang Jianping 
Published: March 2021

AbstractIncreasing the biodiversity of agroecosystems can increase populations of natural enemies that are useful for pest control. Orchards often have a low diversity of plant species, which is not conducive to maintaining ecosystem functions and services. However, additional flowering plants could provide natural enemies with beneficial resources. To assess the ability of flowering plants to attract predators and increase the biological control of Aphis spiraecola Patch, we established individual plots of three different flowering plant species with sequential bloom periods between the rows of apple orchard. These plants attracted predators such as Coccinellidae, Syrphidae, and Chrysopidae when flowering. The density of predators on trees in the three flowering plant plots was significantly higher than that in the control, whereas the density of aphids on trees in Orychophragmus violaceus (L.) O. E. Schulz (Rhoeadales: Brassicaceae) and Cnidium monnieri (Linn.) Cuss. (Apiales: Apiaceae) plots were significantly lower than that in control. The density of aphids on trees in Calendula officinalis L. (Asterales: Asteraceae) plots was significantly lower than in other plots at second peak period. There was a significant negative correlation between the population of aphids and predators on trees at peak of aphids. Cage exclusion tests showed that the biocontrol services index (BSI) of O. violaceus was highest (32.7%) on 24 May, and the BSI of C. monnieri was highest (47.6%) on 7 June. Our results suggest that the temporal combination of different flowering plants could provide useful effective biocontrol to management pest in orchard.
Long-Term Colorectal Cancer Incidence and Mortality After Colonoscopy Screening According to Individuals’ Risk Profiles
Authors: Wang Kai , Ma Wenjie , Wu Kana , Ogino Shuji , Giovannucci Edward L , Chan Andrew T , Song Mingyang 
Published: March 2021

Abstract

Background
It remains unknown whether the benefit of colonoscopy screening against colorectal cancer (CRC) and the optimal age to start screening differ by CRC risk profile.

Methods
Among 75 873 women and 42 875 men, we defined a CRC risk score (0-8) based on family history, aspirin, height, body mass index, smoking, physical activity, alcohol, and diet. We calculated colonoscopy screening-associated hazard ratios and absolute risk reductions (ARRs) for CRC incidence and mortality and age-specific CRC cumulative incidence according to risk score. All statistical tests were 2-sided.

Results
During a median of 26 years of follow-up, we documented 2407 CRC cases and 874 CRC deaths. Although the screening-associated hazard ratio did not vary by risk score, the ARRs in multivariable-adjusted 10-year CRC incidence more than doubled for individuals with scores 6-8 (ARR = 0.34%, 95% confidence interval [CI] = 0.26% to 0.42%) compared with 0-2 (ARR = 0.15%, 95% CI = 0.12% to 0.18%, Ptrend &lt; .001). Similar results were found for CRC mortality (ARR = 0.22%, 95% CI = 0.21% to 0.24% vs 0.08%, 95% CI = 0.07% to 0.08%, Ptrend &lt; .001). The ARR in mortality of distal colon and rectal cancers was fourfold higher for scores 6-8 than 0-2 (distal colon cancer: ARR = 0.08%, 95% CI = 0.07% to 0.08% vs 0.02%, 95% CI = 0.02% to 0.02%, Ptrend &lt; .001; rectal cancer: ARR = 0.08%, 95% CI = 0.08% to 0.09% vs 0.02%, 95% CI = 0.02% to 0.03%, Ptrend &lt; .001). When using age 45 years as the benchmark to start screening, individuals with risk scores of 0-2, 3, 4, 5, and 6-8 attained the threshold CRC risk level (10-year cumulative risk of 0.47%) at age 51 years, 48 years, 45 years, 42 years, and 38 years, respectively.

Conclusions
The absolute benefit of colonoscopy screening is more than twice higher for individuals with the highest than lowest CRC risk profile. Individuals with a high- and low-risk profile may start screening up to 6-7 years earlier and later, respectively, than the recommended age of 45 years.
Feasibility of Medical Student Mentors to Improve Transition in Sickle Cell Disease
Authors: Viola Adrienne S , Drachtman Richard , Kaveney Amanda , Sridharan Ashwin , Savage Beth , Delnevo Cristine D , Coups Elliot J , Porter Jerlym S , Devine Katie A 
Published: March 2021

AbstractObjectiveAdvances in medical care have resulted in nearly 95% of all children with sickle cell disease (SCD) living to adulthood. There is a lack of effective transition programming, contributing to high rates of mortality and morbidity among adolescents and young adults (AYAs) during the transition from pediatric to adult healthcare. This nonrandomized study evaluated the feasibility, acceptability, and preliminary outcomes of a novel medical student mentor intervention to improve transition outcomes for AYA with SCD.MethodsEligible participants were ages 18–25 years, either preparing for transition or had transferred to adult care within the past year. Twenty-four AYA with SCD (Mage = 20.3, SD = 2.6) enrolled in the program and were matched with a medical student mentor. Feasibility and acceptability of the intervention was assessed through enrollment rates, reasons for refusal, retention rates, engagement with the intervention, satisfaction, and reasons for drop-out. Dependent t-tests were used to evaluate the preliminary effects of the intervention on patient transition readiness, health-related quality of life, self-efficacy, SCD knowledge, medication adherence, and health literacy.ResultsParticipants (N = 24) demonstrated adequate retention (75.0%), adherence to the intervention (M = 5.3 of 6 sessions), and satisfaction with the intervention components. Participants demonstrated significant improvements in transition readiness (p = .001), self-efficacy (p = .002), medication adherence (p = .02), and health literacy (p = .05).ConclusionsA medical student mentor intervention to facilitate transition from pediatric to adult care for AYA with SCD is both feasible and acceptable to patients and medical students. Preliminary results suggest benefits for patients, warranting a larger efficacy study.
Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a rare cause of acute abdomen
Authors: Ojeda Rommel , Molina Gabriel A , Jiménez Galo E , González Hernán , Pinto Johanna C , Jiménez Andres , Leon Flor M 
Published: March 2021

Abstract
Sclerosing angiomatoid nodular transformation (SANT) of the spleen is an extremely rare benign lesion. It originates from the spleen's red pulp; however, its pathogenesis is not clearly defined. These tumors are usually asymptomatic or cause nonspecific abdominal symptoms. Most SANTs are found incidentally on radiographic examination or during surgery for an unrelated condition. The differential diagnosis from other splenic tumors or malignant lesions can be challenging due to the risk for a possible malignancy of the suspicious lesion. As more SANTs are being discovered and treated, they should always be considered in the differential.
We present the case of an otherwise healthy 30-year-old female; she presented with abdominal pain and a mass in her spleen. Surgery was performed, and an SANT was discovered. The patient underwent full recovery, and on follow-up is doing well.
Negation as a modality in a quantified setting
Authors: Speranski Stanislav O 
Published: March 2021

AbstractThe idea of treating negation as a modality manifests itself in various logical systems, especially in Došen’s propositional logic $\textsf {N}$, whose negation is weaker than that of Johansson’s minimal logic. Among the interesting extensions of $\textsf {N}$ are the propositional logics $\textsf {N}^{\ast }$ and $\textsf {Hype}$; the former was proposed in Cabalar et al. (2006, Proceedings of the 10th International Conference on Principles of Knowledge Representation and Reasoning, 25–36), while the latter has recently been advocated in Leitgeb (2019, J. Philos. Logic, 48, 305–405), but was first introduced in Moisil (1942, Disquisitiones Math. et Phys., 2, 3–98). I shall develop predicate versions of $\textsf {N}$ and $\textsf {N}^{\ast }$ and provide a simple Routley-style semantics for the predicate version of $\textsf {Hype}$. The corresponding strong completeness results will be proved by means of a useful general technique. It should be remarked that this work can also be seen as a starting point for the investigation of intuitionistic predicate modal logics.
The morphology of the X-ray afterglows and of the jetted GeV emission in long GRBs
Authors: Ruffini R , Moradi R , Rueda J A , Li L , Sahakyan N , Chen Y-C , Wang Y , Aimuratov Y , Becerra L , Bianco C L , Cherubini C , Filippi S , Karlica M , Mathews G J , Muccino M , Pisani G B , Xue S S 
Published: March 2021

ABSTRACT
We recall evidence that long gamma-ray bursts (GRBs) have binary progenitors and give new examples. Binary-driven hypernovae (BdHNe) consist of a carbon–oxygen core (COcore) and a neutron star (NS) companion. For binary periods ∼5 min, the COcore collapse originates the subclass BdHN I characterized by (1) an outstanding supernova (SN; the ‘SN-rise’); (2) a black hole (BH), born from the NS collapse by SN matter accretion, leading to a GeV emission with luminosity $L_{\rm GeV} = A_{\rm GeV}\, t^{-\alpha _{\rm GeV}}$, observed only in some cases; and (3) a new NS (νNS), born from the SN, originating from the X-ray afterglow with $L_\mathrm{ X} = A_{\rm X}\, t^{-\alpha _{\rm X}}$, observed in all BdHN I. We record 378 sources and present for four prototype GRBs 130427A, 160509A, 180720B, and 190114C: (1) spectra, luminosities, SN-rise duration; (2) AX, αX = 1.48 ± 0.32, and (3) the νNS spin time evolution. We infer (i) AGeV, αGeV = 1.19 ± 0.04 and (ii) the BdHN I morphology from time-resolved spectral analysis, three-dimensional simulations, and the GeV emission presence/absence in 54 sources within the Fermi-Large Area Telescope boresight angle. For 25 sources, we give the integrated and time-varying GeV emission, 29 sources have no GeV emission detected and show X/gamma-ray flares previously inferred as observed along the binary plane. The 25/54 ratio implies the GeV radiation is emitted within a cone of half-opening angle ≈60° from the normal to the orbital plane. We deduce BH masses of 2.3–8.9 M⊙ and spin of 0.27–0.87 by explaining the GeV emission from the BH rotational energy extraction, while their time evolution validates the BH mass–energy formula.
Particle acceleration in radio galaxies with flickering jets: GeV electrons to ultrahigh energy cosmic rays
Authors: Matthews James H , Taylor Andrew M 
Published: March 2021

ABSTRACT
Variability is a general property of accretion discs and their associated jets. We introduce a semi-analytical model for particle acceleration and radio jet/lobe evolution and explore the effect of Myr time-scale jet variability on the particles accelerated by an active galactic nucleus (AGN) jet. Our work is motivated by the need for local powerful ultrahigh energy cosmic ray (UHECR) sources and evidence for variability in AGN and radio galaxies. Our main results are (i) UHECR and non-thermal radiative luminosities track the jet power but with a response set by the escape and cooling times, respectively; (ii) jet variability produces structure in the electron, synchrotron, and UHECR spectra that deviates from that produced for a constant jet power – in particular, spectral hardening features may be signatures of variability; (iii) the cutoff in the integrated cosmic ray (CR) spectrum is stretched out due to the variation in jet power (and, consequently, maximum CR energy). The resulting spectrum is the convolution of the jet power distribution and the source term. We derive an approximate form for a lognormal distribution of powers; and (iv) we introduce the idea of ${\sim}10\,$ GeV ‘proxy electrons’ that are cooling at the same rate that UHECRs of rigidity $10\,$ EV are escaping from the source, and determine the corresponding photon frequencies that probe escaping UHECRs. Our results demonstrate the link between the history of an astrophysical particle accelerator and its particle contents, non-thermal emission, and UHECR spectrum, with consequences for observations of radio galaxies and UHECR source models.
Radiative parameters of high-lying levels in neutral rhodium
Authors: Li Yongfan , Geng Yidan , Liu Meina , Ma Huiting , Wu Yaxin , Zhang Lijun , Gamrath Sébastien , Quinet Pascal , Dai Zhenwen 
Published: March 2021

ABSTRACTRadiative lifetimes of 20 high-lying excited levels in neutral rhodium (Rh i) were measured using time-resolved laser-induced fluorescence technique, 17 of which are reported for the first time to our knowledge. These lifetimes were combined with theoretical branching fractions obtained from pseudo-relativistic Hartree–Fock calculations to deduce semi-empirical transition probabilities and oscillator strengths for 63 Rh i spectral lines.
Updated parameters of 1743 open clusters based on Gaia DR2
Authors: Dias W S , Monteiro H , Moitinho A , Lépine J R D , Carraro G , Paunzen E , Alessi B , Villela L 
Published: March 2021

ABSTRACT
In this study, we follow up our recent paper (Monteiro et al. 2020) and present a homogeneous sample of fundamental parameters of open clusters in our Galaxy, entirely based on Gaia DR2 data. We used published membership probability of the stars derived from Gaia DR2 data and applied our isochrone fitting code, updated as in Monteiro et al. (2020), to GBP and GRPGaia DR2 data for member stars. In doing this, we take into account the nominal errors in the data and derive distance, age, and extinction of each cluster. This work therefore provides parameters for 1743 open clusters and, as a by-product, a list of likely not physical or dubious open clusters is provided as well for future investigations. Furthermore, it was possible to estimate the mean radial velocity of 831 clusters (198 of which are new and unpublished so far), using stellar radial velocities from Gaia DR2 catalogue. By comparing the open cluster distances obtained from isochrone fitting with those obtained from a maximum likelihood estimate of individual member parallaxes, we found a systematic offset of (−0.05 ± 0.04) mas.
Constraining planetesimal stirring: how sharp are debris disc edges?
Authors: Marino Sebastian 
Published: March 2021

ABSTRACT
The dust production in debris discs by grinding collisions of planetesimals requires their orbits to be stirred. However, stirring levels remain largely unconstrained, and consequently the stirring mechanisms as well. This work shows how the sharpness of the outer edge of discs can be used to constrain the stirring levels. Namely, the sharper the edge the lower the eccentricity dispersion must be. For a Rayleigh distribution of eccentricities (e), I find that the disc surface density near the outer edge can be parametrized as tanh [(rmax  − r)/lout], where rmax  approximates the maximum semimajor axis and lout defines the edge smoothness. If the semimajor axis distribution has sharp edges erms is roughly 1.2lout/rmax  or erms = 0.77lout/rmax  if semimajor axes have diffused due to self-stirring. This model is fitted to Atacama Large Millimeter/submillimeter Array data of five wide discs: HD 107146, HD 92945, HD 206893, AU Mic, and HR 8799. The results show that HD 107146, HD 92945, and AU Mic have the sharpest outer edges, corresponding to erms values of 0.121 ± 0.05, $0.15^{+0.07}_{-0.05}$, and 0.10 ± 0.02 if their discs are self-stirred, suggesting the presence of Pluto-sized objects embedded in the disc. Although these stirring values are larger than typically assumed, the radial stirring of HD 92945 is in good agreement with its vertical stirring constrained by the disc height. HD 206893 and HR 8799, on the other hand, have smooth outer edges that are indicative of scattered discs since both systems have massive inner companions.
Constraining the state of the intergalactic medium during the Epoch of Reionization using MWA 21-cm signal observations
Authors: Ghara Raghunath , Giri Sambit K , Ciardi Benedetta , Mellema Garrelt , Zaroubi Saleem 
Published: March 2021

ABSTRACT
The Murchison Widefield Array (MWA) team has derived new upper limits on the spherically averaged power spectrum of the 21-cm signal at six redshifts in the range z ≈ 6.5–8.7. We use these upper limits and a Bayesian inference framework to derive constraints on the ionization and thermal state of the intergalactic medium (IGM) as well as on the strength of a possible additional radio background. We do not find any constraints on the state of the IGM for z ≳ 7.8 if no additional radio background is present. In the presence of such a radio background, the 95 per cent credible intervals of the disfavoured models at redshift ≳ 6.5 correspond to an IGM with a volume-averaged fraction of ionized regions below 0.6 and an average gas temperature ≲ 103 K. In these models, the heated regions are characterized by a temperature larger than that of the radio background, and by a distribution with characteristic size $\lesssim 10\, h^{-1}$ Mpc and a full width at half maximum (FWHM) of $\lesssim 30\, h^{-1}$ Mpc. Within the same credible interval limits, we exclude an additional radio background of at least $0.008{{\ \rm per\ cent}}$ of the CMB at 1.42 GHz.