bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic carbon [C i](3P1–3P0) mapping of the nearby galaxy M 83
Authors: Miyamoto Yusuke , Yasuda Atsushi , Watanabe Yoshimasa , Seta Masumichi , Kuno Nario , Salak Dragan , Ishii Shun , Nagai Makoto , Nakai Naomasa 
Published: March 2021

AbstractAtomic carbon (C i) has been proposed to be a global tracer of the molecular gas as a substitute for CO, however, its utility remains unproven. To evaluate the suitability of C i as the tracer, we performed [C i](3P1–3P0) [hereinafter [C i](1–0)] mapping observations of the northern part of the nearby spiral galaxy M 83 with the Atacama Submillimeter Telescope Experiment (ASTE) telescope and compared the distributions of [C i](1–0) with CO lines [CO(1–0), CO(3–2), and 13CO(1–0)], H i, and infrared (IR) emission (70, 160, and 250 μm). The [C i](1–0) distribution in the central region is similar to that of the CO lines, whereas [C i](1–0) in the arm region is distributed outside the CO. We examined the dust temperature, Tdust, and dust mass surface density, Σdust, by fitting the IR continuum-spectrum distribution with a single-temperature modified blackbody. The distribution of Σdust shows a much better consistency with the integrated intensity of CO(1–0) than with that of [C i](1–0), indicating that CO(1–0) is a good tracer of the cold molecular gas. The spatial distribution of the [C i] excitation temperature, Tex, was examined using the intensity ratio of the two [C i] transitions. An appropriate Tex at the central, bar, arm, and inter-arm regions yields a constant [C]$/$[H2] abundance ratio of ∼7 × 10−5 within a range of 0.1 dex in all regions. We successfully detected weak [C i](1–0) emission, even in the inter-arm region, in addition to the central, arm, and bar regions, using spectral stacking analysis. The stacked intensity of [C i](1–0) is found to be strongly correlated with Tdust. Our results indicate that the atomic carbon is a photodissociation product of CO, and consequently, compared to CO(1–0), [C i](1–0) is less reliable in tracing the bulk of “cold” molecular gas in the galactic disk.
Effects of fenofibrate therapy on renal function in primary gout patients
Authors: Li Xinde , Sun Wenyan , Lu Jie , He Yuwei , Chen Ying , Ren Wei , Cui Lingling , Liu Zhen , Wang Can , Wang Xuefeng , Ma Lidan , Cheng Xiaoyu , Han Lin , Li Hailong , Zhang Hui , Yuan Xuan , Ji Xiaopeng , Ji Aichang , Merriman Tony R , Li Changgui 
Published: March 2021

Abstract

Objective
To investigate the incidence and potential risk factors for development of fenofibrate-associated nephrotoxicity in gout patients.

Methods
A total of 983 gout patients on fenofibrate treatment who visited the dedicated Gout Clinic at the Affiliated Hospital of Qingdao University between September 2016 and June 2020 were retrospectively enrolled from the electronic records system. Fenofibrate-associated nephrotoxicity was defined as an increase in serum creatinine (SCr) ≥0.3 mg/dl within 6 months of fenofibrate initiation. The change trend of SCr and uric acid levels during the treatment period were assessed by a generalised additive mixed model (GAMM). Multivariate analysis was performed for risk factors affecting elevated SCr.

Results
A total of 100 (10.2%) patients experienced an increase in SCr ≥0.3 mg/dl within 6 months after fenofibrate initiation. The median change of SCr in the whole cohort was 0.11 mg/dl [interquartile range (IQR) 0.03–0.20], whereas it was 0.36 (0.33–0.45) in the fenofibrate-associated nephrotoxicity group. In a multivariable regression model, chronic kidney disease (CKD) [odds ratio (OR) 2.39 (95% CI 1.48, 3.86)] and tophus [OR 2.29 (95% CI 1.39, 3.78)] were identified to be risk predictors, independent of measured covariates, of fenofibrate-associated nephrotoxicity. During the treatment period, although SCr temporarily increased, serum urate and triglyceride concentrations decreased using the interaction analysis of GAMM. Of those with fenofibrate withdrawal records, the SCr increase in 65% of patients was reversed after an average of 49 days off the drug.

Conclusions
This observational study implied that fenofibrate-associated nephrotoxicity occurs frequently in gout patients, especially in patients with tophi or CKD. The potential renal risks of fenofibrate usage in gout needs additional research.
The burden of psoriatic arthritis in the biologics era: data from the Belgian Epidemiological Psoriatic Arthritis Study
Authors: de Vlam Kurt , Steinfeld Serge , Toukap Adrien Nzeusseu , van den Bosch Filip , Joos Rik , Geysens Piet , Leroi Hermine , Lories Rik 
Published: March 2021

AbstractObjectivesTo characterize the frequency of PsA subtypes, estimate the severity based on damage and inflammation and estimate the impact of PsA on patients’ health-related quality of life.MethodsWe conducted a longitudinal observational study in 17 academic and non-academic centres in Belgium. Patients with PsA fulfilling Classification Criteria for Psoriatic Arthritis were recruited. Three visits were scheduled: at baseline (T0), at 1 year (±1 month; T1) and at 2 years (±1 month; T2) of follow-up. Demographics, clinical data and patient-reported outcome measures were collected at T0, T1 and T2. X-rays of the hands and feet were collected yearly (T0, T1 and T2). X-rays of the spine were collected at T0 and T2. Here we report on the burden of disease based on the clinical data and patient-reported outcomes.ResultsA total of 461 patients were recruited; 73.5% had combined peripheral and axial involvement and 13.7% had hip involvement. Plaque psoriasis was predominant (83.9%). At inclusion, 42.7% and 58.8% had no tender or swollen joints, respectively. Dactylitis and enthesitis were still present in 13.7% and 24.1% of the patients, respectively. Patients was treated with DMARDs (68%) and/or anti-TNF (44.2%). Forty-three per cent of the patients had a state of minimal disease activity and 62% considered the actual state as satisfactory. The mean HAQ score was 0.7%, with 32.5% of patients having a normal score (&lt;0.3).ConclusionDespite the availability of different treatment options, including biologics (anti-TNF), a substantial number of patients have active disease and have a high disease burden.
Do Community Water Sources Provide Safe Drinking Water? Evidence from a Randomized Experiment in Rural Bangladesh
Authors: Cocciolo Serena , Ghisolfi Selene , Habib Md Ahasan , Rashid S M A , Tompsett Anna 
Published: March 2021

AbstractHealth, and in turn income and welfare, depend on access to safe drinking water. Although the majority of rural households worldwide obtain drinking water from community water sources, there is limited evidence about how effectively these sources provide safe drinking water. This study combines a randomized experiment with water quality testing to evaluate the impact of a program that provides community deep tubewells in rural Bangladesh. The program reduces exposure to arsenic, a major natural pollutant, but not fecal contamination. Households may use fewer sources with fecal contamination, but any such effects are offset by recontamination through transport and possibly storage. The results suggest that while community deep-tubewell construction programs may reduce exposure to arsenic in Bangladesh, reducing exposure to fecal contamination may require interventions that go beyond community sources.
Whole-Genome Sequence Resource of Calonectria ilicicola, the Casual Pathogen of Soybean Red Crown Rot
Authors: Liu Hsien-Hao , Wang Jie , Wu Ping-Hu , Lu Mei-Yeh Jade , Li Jeng-Yi , Shen Yuan-Min , Tzeng Min-Nan , Kuo Chang-Hsin , Lin Ying-Hong , Chang Hao-Xun 
Published: March 2021

Calonectria ilicicola (anamorph: Cylindrocladium parasiticum) is a soilborne plant-pathogenic fungus with a broad host range, and it can cause red crown rot of soybean and Cylindrocladium black rot of peanut, which has become an emerging threat to crop production worldwide. Limited molecular studies have focused on Calonectria ilicicola and one of the possible difficulties is the lack of genomic resources. This study presents the first high quality and near-completed genome of C. ilicicola, using the Oxford Nanopore GridION sequencing platform. A total of 16 contigs were assembled and the genome of C. ilicicola isolate F018 was estimated to have 11 chromosomes. Currently, the C. ilicicola F018 genome represents the most contiguous assembly, which has the lowest contig number and the highest contig N50 among all Calonectria genome resources. Putative protein-coding sequences and secretory proteins were estimated to be 17,308 and 1,930 in the C. ilicicola F018 genome, respectively; and the prediction was close to other plant-pathogenic fungi, such as Fusarium species, within the Nectriaceae family. The availability of this high-quality genome resource is expected to facilitate research on fungal biology and genetics of C. ilicicola and to support advanced understanding of pathogen virulence and disease management. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies in Neonatal Cord Blood After Vaccination in Pregnancy
Authors: Gill Lisa , Jones Cresta W. 
Published: March 2021

BACKGROUND:
Studies evaluating the safety and efficacy of currently available vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not include pregnant participants. No data are available to counsel on vaccine safety and potential for neonatal passive immunity.

CASE:
A 34-year-old multigravid patient working in health care received the Pfizer-BioNTech (BNT162b2) mRNA vaccine for SARS-CoV-2 in the third trimester of pregnancy. Uncomplicated spontaneous vaginal delivery of a female neonate with Apgar scores of 9 and 9 occurred at term. The patient's blood as well as neonatal cord blood were evaluated for SARS-CoV-2–specific antibodies. Both the patient and the neonate were positive for antibodies at a titer of 1:25,600.

CONCLUSION:
In this case, passage of transplacental antibodies for SARS-CoV-2 was shown after vaccination in the third trimester of pregnancy.
Ageing and sociality: why, when and how does sociality change ageing patterns?
Authors: Korb Judith , Heinze Jürgen 
Published: March 2021

Individual lifespans vary tremendously between and also within species, but the proximate and ultimate causes of different ageing speeds are still not well understood. Sociality appears to be associated with the evolution of greater longevity and probably also with a larger plasticity of the shape and pace of ageing. For example, reproductives of several termites and ants reach lifespans that surpass those of their non-reproductive nestmates by one or two decades. In this issue, 15 papers explore the interrelations between sociality and individual longevity in both, group-living vertebrates and social insects. Here, we briefly give an overview of the contents of the various contributions, including theoretical and comparative studies, and we explore the similarities and dissimilarities in proximate mechanisms underlying ageing among taxa, with particular emphasis on nutrient-sensing pathways and, in insects, juvenile hormone. These studies point to an underestimated role of more downstream processes. We highlight the need for reliable transcriptomic markers of ageing and a comprehensive ageing theory of social animals, which includes the reproductive potential of workers, and considers the fact that social insect queens reach maturity only after a prolonged period of producing non-reproductive workers.This article is part of the theme issue ‘Ageing and sociality: why, when and how does sociality change ageing patterns?’
Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England
Authors: Grint Daniel J , Wing Kevin , Williamson Elizabeth , McDonald Helen I , Bhaskaran Krishnan , Evans David , Evans Stephen JW , Walker Alex J , Hickman George , Nightingale Emily , Schultze Anna , Rentsch Christopher T , Bates Chris , Cockburn Jonathan , Curtis Helen J , Morton Caroline E , Bacon Sebastian , Davy Simon , Wong Angel YS , Mehrkar Amir , Tomlinson Laurie , Douglas Ian J , Mathur Rohini , Blomquist Paula , MacKenna Brian , Ingelsby Peter , Croker Richard , Parry John , Hester Frank , Harper Sam , DeVito Nicholas J , Hulme Will , Tazare John , Goldacre Ben , Smeeth Liam , Eggo Rosalind M 
Published: March 2021

AbstractThe B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (HR: 1.67 (95% CI: 1.34 - 2.09; P<.0001)). Absolute risk of death by 28-days increased with age and comorbidities. VOC has potential to spread faster with higher mortality than the pandemic to date.
COVID 19 Knowledge, Attitude, and Practice of the Healthcare Providers in United Arab Emirates
Authors: Alghfeli Aljazia Khalfan , Al Zarouni Amal Abdul Rahim , Alremeithi Hamda Musabbah , Almadhaani Roqayah Abdulla , Alketbi Latifa Baynouna 
Published: March 2021

AbstractBackgroundHealth care providers at increased risk of COVID-19 infection, inadequate knowledge and practice about COVID-19, and infection control may lead to increased risk of disease transmission. Early diagnosis and appropriate management of COVID 19 cases is important in preventing transmission and improving patient outcomes. The aim of this study was to assess the knowledge, altitude, and practice of healthcare providers in the United Arab Emirates toward COVID-19 and to examine its determinants.MethodA cross-sectional study was conducted to assess knowledge, attitudes, and practice (KAP) of Healthcare providers regarding COVID-19. The study was conducted during the COVID-19 pandemic from of April 11 to July 23, using an online anonymous self-administered questionnaire.ResultsA total of 2371 healthcare providers responded to the survey. A total of 1091 worked in inpatient hospitals, 494 in primary health care, and 388 in emergency and ICU care. The overall performance score for all healthcare providers was as follows: 49.1%, poor score; 41.8 %, intermediate score; and 9.2%, good score with a mean result of 17.14. Factors leading to better overall performance scores were years of experience, pediatricians’ specialty, and specialist’s occupation. A total of 55.7% received good direct knowledge from all healthcare providers. In practice, 48% had good practices toward COVID-19. The overall attitude mean was 2.8, from a maximum score of 7, indicating a positive attitude toward COVID-19.ConclusionsThe study-demonstrated gaps in specific aspects of knowledge and practice that should be focused on in future education and HCP awareness. A structured training program targeting all HCPs is needed to have good clinical knowledge and practice about COVID-19.
The relationship between new PCR positive cases and going out in public during the COVID-19 epidemic in Japan
Authors: Takahashi Hiromichi , Terada Iori , Higuchi Takuya , Takada Daisuke , Shin Jung-ho , Kunisawa Susumu , Imanaka Yuichi 
Published: March 2021

AbstractSuppression of the first wave of COVID-19 in Japan is assumedly attributable to people’s increased risk perception by acquiring information from the government and media reports. In this study, going out in public amidst the spread of COVID-19 infections was investigated by examining new polymerase chain reaction (PCR) positive cases of COVID-19 and its relationship to four indicators of people going out in public (the people flow, the index of web searches for going outside, the number of times people browse restaurants, and the number of hotel guests), from the Regional Economic and Social Analysis System (V-RESAS). Two waves of COVID-19 infections were examined with cross-correlation analysis. In the first wave, all four indicators of going out reacted oppositely with the change in new PCR positive cases, showing a lag period of –1 to +6 weeks. In the second wave, the same relationship was only observed for the index of web searches for going outside. These results suggest that going out in public could not be described by new PCR positive cases alone in the second wave, even though they could explain people going out to some extent in the first wave.
Differential Expression of α, β, and γ Protocadherin Isoforms During Differentiation, Aging, and Cancer
Authors: West Michael D. , Labat Ivan , Li Jie , Sim Pam , Janus Jeffrey , Mangelson Hayley , Sullivan Shawn , Liachko Ivan , Labhart Paul , Craske Maddy , Egan Brian , Chapman Karen B. , Malik Nafees N. , Larocca Dana , Sternberg Hal 
Published: March 2021

AbstractThe cadherin family of cell surface glycoproteins plays a fundamental role in cell-cell recognition, thereby participating in diverse biological process such as embryonic morphogenesis and oncogenic transformation. The subset of clustered protocadherin (PCDH) genes generated from the α, β, and γ loci, have been widely studied for their potential role in neuronal cell-cell recognition and neurogenesis, however their broader role in normal embryonic development and cancer has not been examined in detail. We utilized human embryonic stem (hES) cells to model early human developmentin vitro, comparing PCDH isoform transcription in diverse types of embryonic progenitors with normal adult-derived and cancer counterparts. Embryonic progenitors express genes from the α and β cluster at levels comparable to that seen in the CNS, while fetal and adult-derived cells express primarily from the γ cluster. Replicative senescence left fibroblasts with markedly lower expression of all isoforms. We observe that an embryonic pattern of clustered protocadherin gene expression and associated CpG island methylation is commonly associated with cancer cell lines from diverse tissue types. The differential regulation of the α, β, and γ loci coincide with alternate regions of DNA accessibility at CTCF binding sites and lamina-associated domains and CPL expression correlated with the expression ofLMNAandLMNB1. These observations support a potential role for the differential regulation of genes within the clustered protocadherin locus in selective cell-cell adhesion during embryogenesis, regeneration, cancer and aging.
Finite extinction for a doubly nonlinear parabolic equation of fast diffusion type
Authors: Sarkar Md Abu Hanif 
Published: March 2021

PurposeThe purpose of this paper is to find a doubly nonlinear parabolic equation of fast diffusion in a bounded domain.Design/methodology/approachFor positive and bounded initial data, the authors study the initial zero-boundary value problem.FindingsThe findings of this study showed the complete extinction of a continuous weak solution at a finite time.Originality/valueThe extinction time is studied earlier but for the Laplacian case. The authors presented the finite extinction time for the case of p-Laplacian.
Serious games in business process management: a systematic literature review
Authors: Machado Leitão Thiago , Lima Navarro Leonardo Luiz , Flórido Cameira Renato , Silva Edison Renato 
Published: March 2021

PurposeThis study conducts a systematic literature review (SLR) on serious games in the BPM domain, in order to answer: RQ1 – what are BPM games' learning objectives and design characteristics? RQ2 – How rigorously each BPM game was evaluated in terms of their effectiveness and entertainment?.Design/methodology/approachWe followed the PRISMA statement method and systematic literature review standards. Selected studies were analyzed using qualitative evidence synthesis.FindingsWe found 37 references that describe 15 serious games within the BPM domain. Games are diverse, ranging from analog games that need a few hours to complete to complex digital games that require many sessions. Game evaluation should be generally improved as 27 publications can be considered as quasi-experimental or nonexperimental and potentially biased.Research limitations/implicationsFuture research should focus on developing new games about process implementation and using other notations besides BPMN. More studies testing the reliability and validity of existing games in different settings and using more rigorous experimental designs are also necessary. Practitioners can identify thoroughly evaluated games relevant to their learning objectives.Originality/valueThis is the first SLR about BPM games. It consolidates the literature, analyzes, describes and categorizes 15 games with respect to their internal characteristics and evaluation reliability.
WeChat usage during COVID-19 pandemic lockdown: the mediating role of online self-disclosure on quality of friendship and well-being
Authors: Amosun Tunde Simeon , Jianxun Chu , Rufai Olayemi Hafeez , Muhideen Sayibu , Shahani Riffat , Shah Zakir , Koroma Jonathan 
Published: March 2021

Purpose
The purpose of this paper is to investigate university students’ WeChat usage during the COVID-19 pandemic lockdown in relation to the mediating role of online self-disclosure on their quality of friendship and well-being. A model is proposed to explain how students’ interactions occur during the lockdown and the mediatory role which self-disclosure plays in influencing their socio-psychological markup.

Design/methodology/approach
The research model was tested empirically through a survey conducted online with 600 research participants, comprising of university students in China.

Findings
Results in structural equation modeling show that WeChat interaction significantly correlates with the quality of friendship, online self-disclosure but not significantly correlates with well-being, but an indirect relationship was found out in the mediation analysis. There is also a significant relationship between online self-disclosure, quality of friendship and well-being. Mediation analysis shows that online self-disclosure mediates the relationship between interactions on WeChat and quality of friendship; it also mediates the relationship between WeChat interaction and well-being. In all, the results achieved in this study will significantly help provide more insights in comprehending the nuances attached to some socio-psychological aspects of WeChat and how its usage affects people during the period of crisis.

Originality/value
Theoretically based investigation of WeChat usage among university students and its relationship with online self-disclosure, quality of friendship and well-being is still quite scarce, thereby underscoring the needs and significance of a theoretically based study in this regard. This study tested the credibility and validity of the proposed model in the context of the recent COVID-19 pandemic lockdown in China, which is one of the first in recent times.