bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fray Luis de León y Teresa de Jesús: encuentros en el libro = Fray Luis de Leon and Teresa de Jesús: encounters in the book
Authors: Javier San José Lera 
Published: April 2021

La condición histórico-literaria de los textos teresianos no puede ser estudiada sin tener en cuenta el papel intermediario que, en su configuración, en su transmisión y en su valoración, juega la labor filológica de fray Luis de León. El encuentro en el libro del agustino con la Madre resulta esencial y visibiliza el poder sobre la escritura que se ejerce por parte del teólogo salmanticense, a quien se otorga esa capacidad de control, en función de su autoridad, por parte de las responsables carmelitas. El estatus social y cultural del agustino actúa de aval y es esencial para la institucionalización de los escritos de la madre. The literary historical character of the Teresian texts cannot be studied without taking into account the intermediary role that the philological work of Fray Luis de León plays in its configuration, in its transmission and in its evaluation. The encounter in the book of the Augustinian with Teresa is essential and makes visible the power upon writing that is exerted by the Salamanca theologian, based on his prestige, which is recognised by Carmelite authorities. The Augustinian friar social and cultural status acts as a guarantee and it is essential for the institutionalization of the mother’s writings.
Unas notas sobre el prólogo de la Historia del valeroso caballero don Rodrigo de Peñadura = Some notes of the preface of Historia del Valeroso Caballero don Rodrigo de Peñadura
Authors: Suárez Luis Miguel 
Published: April 2021

Este trabajo analiza brevemente los aspectos literarios más importantes del prólogo de la Historia del valeroso caballero don Rodrigo de Peñadura, sátira política en forma de novela que imita el Quijote. Igualmente, a partir de los datos históricos que allí se apuntan trata de establecer una serie de conclusiones en torno al autor y a la publicación de la novela. This paper examines briefly the most important literary aspects of the preface to Historia del valeroso caballero don Rodrigo de Peñadura, political satire in the form of a novel that imitates the Quixote. Likewise, from the historical data pointed out there, it tries to establish a series of conclusions about the author and the publication of the novel.
Optimization Shortest One-Way Path for Energy Saving Auto Robot Collecting Floating Garbage using Fast Approximate Nearest Neighbor Search
Authors: Nuanmeesri Sumitra , Poomhiran Lap 
Published: April 2021

Floating garbage is a global problem that needs to be cleared and disposed of from the sea and rivers or canals. Mostly the floating plastic garbage directly affects the ecology and the aquatic animals. This paper proposes to develop a low-cost auto robot from waste materials in the household, school, or agriculture, then combines with the Internet of Things technology and focusing on the power energy saving with the highest accuracy in operation of floating garbage collection. ESP32 development kit board is the primary controller with a camera module and ultrasonic sensor for detecting the floating garbage while moving on the water’s surface in the boundary of the specified area, including the small canal, rectangle area, and no rectangle area. The mixed mode is a new method to define the shortest one-way path using a fast approximate nearest neighbor search for the auto robot to detect and collect the floating garbage on the water surface. It was combined between the stationary and the cover model. The mixed mode can eliminate the blind spot area that occurs when using the stationary mode and cover mode. As a result, the auto robot system’s accuracy in mixed mode is 98.3%. It was found that the development of the shortest one-way path for the auto robot collecting floating garbage by mixed mode provides the highest efficiency in detecting floating garbage and also helps to save overall costs, and the resource consumption is nearly half of cover mode consumption.
Estresse ocupacional e os impactos na saúde das assistentes sociais de uma Unidade Hospitalar de atendimento à criança em Boa Vista - Roraima
Authors: Medeiros Tatianne Lorenna Vieira , Lopes Kesy Stheffany Silva , Oliveira Janaine Voltolini de 
Published: April 2021

O objetivo deste estudo é discutir a atuação profissional de assistentes sociais no contexto de uma unidade hospitalar de atendimento à criança em Boa Vista – Roraima, e os impactos do trabalho na saúde mental destas profissionais, em específico, do estresse ocupacional. Idealizada a partir das vivências em campo durante o ano de 2019, nas disciplinas de Estágio Supervisionado em Serviço Social I e II, a pesquisa, de abordagem mista, realizada com base em revisão bibliográfica, pesquisa-ação e entrevistas a partir de questionários com 18 profissionais, possibilitou, além da observação da realidade institucional e do fazer profissional, o revisitar de conteúdos e a reflexão, por parte das profissionais, sobre o mundo do trabalho, as demandas cotidianas e sua relação com a saúde mental.
Análise sobre formas estratégicas nos discursos fascistas e do integralismo de Plínio Salgado
Authors: Cazetta Felipe Azevedo 
Published: April 2021

Este artigo vem com o objetivo de traçar comparações entre os fascismos e o integralismo, a partir da utilização do totalitarismo como uma das formas de ascensão ao poder, por ambos os movimentos, tanto o europeu quanto o brasileiro. Entretanto, a pesquisa vislumbra tecer não só similaridades mas, examinar as divergências entre as balizas abordadas, através da observação do corpo teórico do Sigma.
ANALYSIS OF ACCEPTANCE OF E-HEALTH APPLICATION BY USERS IN PRIMARY HEALTHCARE CENTER IN SURABAYA CITY
Authors: Wahyu Astani Ni Made Mira , Puspitaning Ati Ni Luh Putu Arum , Ernawaty Ernawaty 
Published: April 2021

This study used the observational quantitative method to analyze the acceptance of information technology in the form of thee-Health. The theory of acceptance was further analyzed using the Unified Theory of Acceptance and Use of Technology (UTAUT) model. UTAUT model is the latest unified model that is an appropriate to explain the acceptance and use of information systems. The research objective was to analyze perceptions of the use of e-Health applications in the Surabaya City Health Center. The research design method used was cross-sectional design. The selected samples of 100 people were determined by multistage sampling in primary healthcare centers in every area of Surabaya. The independent variables in this study were performance expectancy, effort expectancy, social influence and behavioral intention while the dependent variable was the use of e-Health applications. Data were collected through questionnaires delivered via interviews. The results showed that the lowest indicator of acceptance by the users was the time needed to input data category to the e-Health application. This study concludes that the acceptance of e-Health by users primary healthcare centers in Surabaya is low. This study suggests a more widespread dissemination of information regarding the benefits of the use of e-Health along with technical assistance and guidance on the use of e-Health applications.Keywords: UTAUT Model, e-Health application, primary healthcare center, acceptance
Development of a core outcome set for the evaluation of interventions to enhance trial participation decisions on behalf of adults who lack capacity to consent: a mixed methods study (COnSiDER Study)
Authors: Shepherd Victoria , Wood Fiona , Robling Michael , Randell Elizabeth , Hood Kerenza 
Published: April 2021

Abstract
BackgroundTrials involving adults who lack capacity to provide consent for themselves rely on proxy or surrogate decision-makers, usually a family member, to make decisions about participation. Following decades of innovations to improve informed consent in trials, the first interventions to enhance proxy decisions about trial participation are now being developed. However, a lack of standardised outcome measurement in the evaluation of these novel interventions will impede comparisons between their effectiveness. The aim of this study was to establish an agreed standardised core outcome set (COS) for use when evaluating interventions to improve proxy decisions about trial participation on behalf of adults who lack capacity to consent.MethodsWe used established methods to develop the COS including a consensus study with key stakeholder groups comprising those who will use the COS in research (researchers and healthcare professionals) and patients or their representatives. Following a scoping review to identify candidate items, we used a modified two-round Delphi survey to achieve consensus on core outcomes, with equivocal items taken to a consensus meeting for discussion. The COS was finalised following an online consensus meeting in October 2020.ResultsA total of 28 UK stakeholders (5 researchers, 10 trialists, 3 patient/family representatives, 7 recruiters and 3 advisors/approvers) participated in the online Delphi survey to rank candidate items. Items were broadly grouped into three categories: how family members make decisions, their experiences of making decisions, and the personal aspects that influence the decision. Following the Delphi survey, 27 items were included and ten items exhibited no consensus which required discussion at the consensus meeting. Sixteen participants attended the meeting, including additional patient/family representatives invited to increase representation from this key group. We reached consensus for the inclusion of 28 outcome items, including one selected at the consensus meeting.ConclusionsThe study identified outcomes that should be measured as a minimum in all evaluations of interventions to enhance proxy decisions about trials. Further work is required to identify appropriate measures and timing of outcome measurement. Enhancing the quality of proxy decisions will help improve trial participation decisions for these vulnerable groups. Trial registration: The study is registered on the COMET database (https://www.comet-initiative.org/Studies/Details/1409)
Anthropogenic influence on extreme precipitation over global land areas seen in multiple observational datasets
Authors: Madakumbura Gavin D. , Thackeray Chad W. , Norris Jesse , Goldenson Naomi , Hall Alex 
Published: April 2021

Abstract
The intensification of extreme precipitation under anthropogenic forcing is robustly projected by global climate models, but highly challenging to detect in the observational record. Large internal variability distorts this anthropogenic signal. Models produce diverse magnitudes of precipitation response to anthropogenic forcing, largely due to differing schemes for parameterizing subgrid-scale processes. Meanwhile, multiple global observational datasets of daily precipitation exist, developed using varying techniques and inhomogeneously sampled data in space and time. Previous attempts to detect human influence on extreme precipitation have not incorporated model uncertainty, and have been limited to specific regions and observational datasets. Using machine learning methods that can account for these uncertainties and capable of identifying the time evolution of the spatial patterns, we find a physically interpretable anthropogenic signal that is detectable in all global observational datasets. Machine learning efficiently generates multiple lines of evidence supporting detection of an anthropogenic signal in global extreme precipitation.
Efficacy and safety of Qi-Jing Hui-Xin Decoction in the treatment of coronary microvascular angina: Study protocol for a randomized, controlled, multi-center clinical trial
Authors: Sun Yuanlong , Huang Chengxin , Huo Li , Li Yin , Chen Jun , Zhang Zixiu , Jia Meijun , Jiang Meixian , Ruan Xiaofen 
Published: April 2021

Abstract
Background: With the increased understanding of heart disease, microvascular angina (MVA) is receiving greater attention from clinicians. Studies have shown that patients with MVA have significantly higher major cardiovascular events and all-cause mortality than the control population, and the search for effective treatments is of great clinical importance. Both basic and clinical studies have shown that Qi-Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy, but there is a lack of high-quality clinical studies to provide a research basis. This article introduces the evaluation protocol of QJHX for the adjunctive treatment of MVA.Methods/design: This is a prospective randomized controlled trial. The trial will enroll 150 patients with MVA. On the basis of Western drug treatment, patients will be randomized into two groups, and the experimental group will receive QJHX treatment for 12 weeks, and follow up at 24 week. The primary indicators are the clinical efficacy of angina pectoris and the evidence of Traditional Chinese Medicine (TCM) efficacy. Secondary indicators are Seattle Angina Scale score, serum lipid levels, electrocardiogram and echocardiogram diagnosis. Additional indicators are endothelial function and immunoinflammatory factors. Adverse events will be monitored throughout the trial.Discussion: Integrated traditional Chinese and Western medicine is commonly used for angina in China. This study will evaluate the clinical effectiveness and safety of adding QJHX on the basis of standardized Western medications. The results of the trial will provide high-level clinical research-based evidence for the application of QJHX in MVA.Trial registration: This study protocol was registered on 28 October 2019. The registration number is ChiCTR1900027015 at the Chinese Clinical Trial Registry.
Large-strain and Full-color Change Photonic Crystal Films Used as Mechanochromic Strain Sensors
Authors: Zhang Rui , Yang Zhiyu , Zheng Xu , Zhang Yanju , Wang Qing 
Published: April 2021

Abstract
Mechanochromic strain sensors based on photonic crystals, which can change structural color upon mechanical deformation, are promising for many applications including health monitoring and damage detection. Here, a large-strain and full-color change photonic crystal film as a mechanochromic strain sensor is reported. The mechanochromic photonic crystal (MPC) film with grating nanostructure is achieved by a fast and low-cost inverted nanoimprint lithography. The film enables bright and reversible color shift in the full visible range as it is stretched up to a large strain, which is proven in strain direction parallel and perpendicular to the grating. It is demonstrated that the MPC film can be used as a mechanochromic strain sensor able to visualize strain evolution and strain range of low carbon steel in tensile test, which brings a significant step toward visualizing strain monitoring.
Nicotinamide Riboside as a Neuroprotective Therapy for Glaucoma Study Protocol for a Randomized, Double-blind, Placebo-control Trial
Authors: Leung Christopher Kai-shun , Ren Seraph Tianmin , Chan Poemen Pui-man , Wan Kelvin H , Kam Aziz , Lai Gilda , Chiu Vivian , Ko Match , Yiu Cedric , Yu Marco 
Published: April 2021

Abstract
Background Whereas lowering the intraocular pressure (IOP) can slow optic nerve degeneration in glaucoma, many patients with glaucoma continue to develop progressive loss in vision despite significant reduction in IOP. No treatment has been shown to be effective for neuroprotection in glaucoma. We set out to conduct a randomized controlled trial to investigate whether nicotinamide riboside (NR), a nicotinamide adenine dinucleotide precursor, is effective to slow optic nerve degeneration in patients with primary open-angle glaucoma (POAG). We hypothesize that patients treated with NR have a slower rate of progressive retinal nerve fiber layer (RNFL) thinning compared with those treated with placebo. Methods This is a randomized, double blind, placebo controlled, parallel group, multi-center study including 125 patients with POAG. Patients will be randomized to receive 300mg NR or placebo for 24 months. Clinical examination, optical coherence tomography imaging of the RNFL, and visual field (VF) test will be performed at the baseline, 1 month, 4 months, and then at 2-month intervals until 24 months. The primary outcome measure is the rate of RNFL thinning measured over 24 months. The secondary outcome measures include (1) time to VF progression, (2) time to progressive RNFL/ganglion cell inner plexiform layer (GCIPL) thinning, and (3) the rate of change of VF sensitivity over 24 months (to investigate neuroprotection) and 1 month (to investigate neuroenhancement). The rates of RNFL thinning and VF sensitivity decline between treatment groups will be compared with linear mixed modeling. Survival analysis will be performed to compare the differences in time from baseline to VF progression and time from baseline to progressive RNFL/GCIPL thinning between treatment groups using Cox proportional hazards models. Discussion Outcome measures in glaucoma neuroprotection trials have been predicated on detection of VF progression, which may take years to develop and confirm. In addition to addressing whether NR has a neuroprotective/neuroenhancement effect in glaucoma patients, this study will demonstrate the feasibility of studying neuroprotection in a relatively short trial period (24 months) by comparing the rates of progressive RNFL thinning, a more reproducible and objective outcome measure compared with VF endpoints, between treatment groups.
The Thalamus in Trigeminal Neuralgia: Structural and Metabolic Abnormalities, and Influence on Surgical Response
Authors: Danyluk Hayden , Andrews Jennifer , Kesarwani Rohit , Seres Peter , Broad Robert , Wheatley Matt , Sankar Tejas 
Published: April 2021

Abstract
Background
Medically-refractory trigeminal neuralgia (TN) can be treated successfully with operative intervention, but a significant proportion of patients are non-responders despite undergoing technically successful surgery. The thalamus is a key component of the trigeminal sensory pathway involved in transmitting facial pain, but the role of the thalamus in TN, and its influence on durability of pain relief after TN surgery, are relatively understudied. We aimed to test the hypothesis that variations in thalamic structure and metabolism are related to surgical non-response in TN.
Methods
We performed a longitudinal, peri-operative neuroimaging study of the thalamus in medically-refractory TN patients undergoing microvascular decompression or percutaneous balloon compression rhizotomy. Patients underwent structural MRI and MR spectroscopy scans pre-operatively and at 1-week following surgery, and were classified as responders or non-responders based on 1-year post-operative pain outcome. Thalamus volume, shape, and metabolite concentration (choline/creatine [Cho/Cr] and N-acetylaspartate/creatine [NAA/Cr]) were evaluated at baseline and 1-week, and compared between responders, non-responders, and healthy controls.
Results
Twenty healthy controls and 23 patients with medically-refractory TN treated surgically (17 responders, 6 non-responders) were included. Pre-operatively, TN patients as a group showed significantly larger thalamus volume contralateral to the side of facial pain. However, vertex-wise shape analysis showed significant contralateral thalamus volume reduction in non-responders compared to responders in an axially-oriented band spanning the outer thalamic circumference (peak p = 0.019). Further, while pre-operative thalamic metabolite concentrations did not differ between responders and non-responders, as early as 1-week after surgery, every single long-term non-responder showed a distinct decrease in contralateral thalamic Cho/Cr and NAA/Cr, irrespective of surgery type, which was not observed in responders.
Conclusions
Atrophy of the contralateral thalamus is a consistent feature across patients with medically-refractory TN. Regional alterations in preoperative thalamic structure, and very early post-operative metabolic changes in the thalamus, both appear to influence the durability of pain relief after TN surgery.
Cortical Cyclin A controls spindle orientation during asymmetric cell division
Authors: Darnat Pénélope , Burg Angelique , Sallé Jérémy , Lacoste Jérôme , Louvet-Vallée Sophie , Gho Michel , Audibert Agnes 
Published: April 2021

Abstract
Cell proliferation and cell polarity need to be precisely coordinated to orient the asymmetric cell divisions crucial for generating cell diversity in epithelia. In many instances, the Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is spatially and temporally coordinated with cell cycle progression has remained elusive. Using Drosophila sensory organ precursor cells as a model system, we show that Cyclin A, the main Cyclin driving the transition to M-phase of the cell cycle, is recruited to the apical-posterior cortex in prophase by the Frizzled/Dishevelled complex. This cortically localized Cyclin A then regulates the orientation of the division by recruiting Mud, a homologue of NuMA, the well-known spindle-associated protein. The observed non-canonical subcellular localization of Cyclin A reveals this mitotic factor as a direct link between cell proliferation, cell polarity and spindle orientation.
Coarse-Grained Geological Porous Media Structure Modeling Using Heuristic Algorithm and Evaluation of Porosity, Hydraulic Conductivity, and Pressure Drop with Experimental Results
Authors: Bezaatpour Javad , Fatehifar Esmaeil , Rasoulzadeh Ali 
Published: April 2021

Abstract
Knowledge of porous media structure is an essential part of the hydrodynamic investigation of fluid flow in porous media. To study soil behavior (as a granular porous media) and water and contaminant movement in the vadose zone, appropriate estimation of soil water retention curve (SWRC) and soil hydraulic conductivity curve (SHCC) has a pivotal role and is one of the most challenging topics for researchers and engineers in soil and water science. The SWCR can be approximated using an accurate particle size distribution (PSD) function. In this study by applying random close packing (RCP) method as an encouraging method for predicting and studying particle configuration, an optimal particle size distribution is developed for coarse-grained soils (0.025 mm < PSD < 3.35mm). The mentioned RCP is generated using heuristic algorithm with merging applicable equations of soil science. For porous media modeling, MATLAB software is used and the predicted results by the optimal model for the parameters of porosity, pressure drop, and saturated hydraulic conductivity are compared with laboratory measurements. Experimental design is conducted by MINITAB and predicted coarse-grained soils structure by the model is compared with 4 sifted soils. The results of the sensitivity analysis showed that the porosity obtained from the model is strongly sensitive to the resolution factor and should be chosen with a sufficiently large amount (higher than 250). Results showed good consistency (up to 95%) between predicted porosity and only 10% difference in pressure drop and permeability with observed measurements.