bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wide-band self-collimation in a low-refractive-index hexagonal lattice
Authors: Xia Chun , Kuebler Stephen M. , Martinez Noel P. , Martinez Manuel , Rumpf Raymond C. , Touma Jimmy 
Published: April 2021

Wide-angle, broadband self-collimation (SC) is demonstrated in a hexagonal photonic crystal (PhC) fabricated in a low-refractive-index photopolymer by multiphoton lithography. The PhC can be described as a hexagonal array of cylindrical air holes in a block of dielectric material having a low-refractive index. Optical characterization shows that the device strongly self-collimates light at near-infrared wavelengths that span 1360 to 1610 nm. SC forces light to flow along the extrusion direction of the lattice without diffractive spreading, even when light couples into the device at high oblique angles. Numerical simulations corroborate the experimental findings.
Distinct transcriptional profiles of Leptospira borgpetersenii serovar Hardjo strains JB197 and HB203 cultured at different temperatures
Authors: Putz Ellie J. , Sivasankaran Sathesh K. , Fernandes Luis G. V. , Brunelle Brian , Lippolis John D. , Alt David P. , Bayles Darrell O. , Hornsby Richard L. , Nally Jarlath E. 
Published: April 2021

BackgroundLeptospirosis is a zoonotic, bacterial disease, posing significant health risks to humans, livestock, and companion animals around the world. Symptoms range from asymptomatic to multi-organ failure in severe cases. Complex species-specific interactions exist between animal hosts and the infecting species, serovar, and strain of pathogen.Leptospira borgpeterseniiserovar Hardjo strains HB203 and JB197 have a high level of genetic homology but cause different clinical presentation in the hamster model of infection; HB203 colonizes the kidney and presents with chronic shedding while JB197 causes severe organ failure and mortality. This study examines the transcriptome ofL.borgpeterseniiand characterizes differential gene expression profiles of strains HB203 and JB197 cultured at temperatures during routine laboratory conditions (29°C) and encountered during host infection (37°C).Methodology/Principal findingsL.borgpeterseniiserovar Hardjo strains JB197 and HB203 were isolated from the kidneys of experimentally infected hamsters and maintained at 29°C and 37°C. RNAseq revealed distinct gene expression profiles; 440 genes were differentially expressed (DE) between JB197 and HB203 at 29°C, and 179 genes were DE between strains at 37°C. Comparison of JB197 cultured at 29°C and 37°C identified 135 DE genes while 41 genes were DE in HB203 with those same culture conditions. The consistent differential expression ofligB, which encodes the outer membrane virulence factor LigB, was validated by immunoblotting and 2D-DIGE. Differential expression of lipopolysaccharide was also observed between JB197 and HB203.Conclusions/SignificanceInvestigation of theL.borgpeterseniiJB197 and HB203 transcriptome provides unique insight into the mechanistic differences between acute and chronic disease. Characterizing the nuances of strain to strain differences and investigating the environmental sensitivity ofLeptospirato temperature is critical to the development and progress of leptospirosis prevention and treatment technologies, and is an important consideration when serovars are selected and propagated for use as bacterin vaccines as well as for the identification of novel therapeutic targets.
Delirium researchers’ perspectives of the challenges in delirium biomarker research: A qualitative study
Authors: Amgarth-Duff Ingrid , Hosie Annmarie , Caplan Gideon A. , Agar Meera 
Published: April 2021

BackgroundDespite the prevalence and impact of delirium, its pathophysiology remains unclear. In order to advance this field of research, robust scientific methodology is required, yet quality of reporting in this field of research has been highly inconsistent. Delirium biomarker research poses several challenges, none of which have been documented in the literature before. The aim of this study was to explore the perspectives of delirium researchers about key methodological issues in delirium biomarker research.MethodsFollowing a Delphi study with delirium experts resulting in 60 recommendations for reporting delirium biomarker studies, semi-structured interviews with international delirium researchers were conducted. Interviews were audio-taped and transcribed verbatim, followed by thematic analysis of the qualitative data.ResultsFifteen participants were interviewed between August and November 2019. Most were male (n = 12; 75%), clinician researchers (n = 13; 86%), and had more than ten years’ experience in conducting delirium research (n = 9; 60%). Analysis revealed two major themes and ten sub-themes, outlining key considerations to advance the field of delirium biomarker research. The major themes were: 1) Practical and scientific challenges of delirium biomarker research: stagnation versus driving improved methods and reporting; and 2) Valuing delirium research through investment and collaboration.ConclusionFindings identified a range of factors that contribute to the practical and ethical challenges of conducting delirium biomarker research, which have not previously been explicitly acknowledged or reported. A clear vision for collaborative efforts to enhance research quality for improved impact was also presented by the delirium researchers. This work complements the preceding Delphi and together these studies provide an in-depth understanding of what is needed in the field to inform and improve methods and reporting of delirium biomarker research.
Reporting health services research to a broader public: An exploration of inconsistencies and reporting inadequacies in societal publications
Authors: Gerrits Reinie G. , van den Berg Michael J. , Kunst Anton E. , Klazinga Niek S. , Kringos Dionne S. 
Published: April 2021

Introduction
Little is known about the accuracy of societal publications (e.g. press releases, internet postings or professional journals) that are based on scientific work. This study investigates a) inconsistencies between scientific peer-reviewed health services research (HSR) publications and non-scientific societal publications and b) replication of reporting inadequacies from these scientific publications to corresponding societal publications.

Methods
A sample of HSR publications was drawn from 116 publications authored in 2016 by thirteen Dutch HSR institutions. Societal publications corresponding to scientific publications were identified through a systematic internet search. We conducted a qualitative, directed content analysis on societal publications derived from the scientific publications to assess both reporting inadequacies and determine inconsistencies. Descriptive frequencies were calculated for all variables. Odds ratios were used to investigate whether inconsistencies in societal publications were less likely when the first scientific author was involved.

Results
We identified 43 scientific and 156 societal publications. 94 societal publications (60.3%), (associated with 32 scientific publications (74.4%)) contained messages that were inconsistent with the scientific work. We found reporting inadequacies in 22 scientific publications (51.2%). In 45 societal publications (28.9%), we found replications of these reporting inadequacies. The likelihood of inconsistencies between scientific and societal publications did not differ when the latter explicitly involved the first scientific author, (OR = 1.44, CI: 0.76–2.74); were published on the institute’s or funder’s website, (OR = 1.32, CI: 0.57–3.06); published with no involvement of a scientific author, (OR = 0.52, CI: 0.25–1.07).

Conclusion
To improve societal publications, one should examine both the consistency with scientific research publications and ways to prevent replication of scientific reporting inadequacies. HSR institutions, funders, and scientific and societal publication platforms should invest in a supportive publication culture to further incentivise the responsible and skilled involvement of researchers in writing both scientific and societal publications.
Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis
Authors: Kuroda Hidekatsu , Fujiwara Yudai , Abe Tamami , Nagasawa Tomoaki , Oguri Takuma , Noguchi Sachiyo , Kamiyama Naohisa , Takikawa Yasuhiro 
Published: April 2021

Background and aims
We investigated the usefulness of combining two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter for assessing the risk of progressive non-alcoholic steatohepatitis, defined as non-alcoholic steatohepatitis with a non-alcoholic fatty liver disease activity score of ≥4 and a fibrosis stage of ≥2.

Methods
This prospective study included 202 patients with non-alcoholic fatty liver disease who underwent two-dimensional shear wave elastography, ultrasound-guided attenuation parameter, vibration-controlled transient elastography, the controlled attenuation parameter, and liver biopsy on the same day. Patients were grouped according to liver stiffness measurement using two-dimensional shear wave elastography and the attenuation coefficient, assessed using the ultrasound-guided attenuation parameter: A, low liver stiffness measurement/low attenuation coefficient; B, low liver stiffness measurement/high attenuation coefficient; C, high liver stiffness measurement/low attenuation coefficient; and D, high liver stiffness measurement/high attenuation coefficient.

Results
Two-dimensional shear wave elastography and vibration-controlled transient elastography had equivalent diagnostic performance for fibrosis. The areas under the curve of the ultrasound-guided attenuation parameter for identifying steatosis grades ≥S1, ≥S2, and S3 were 0.89, 0.91, and 0.92, respectively, which were significantly better than those of the controlled attenuation parameter (P<0.05). The percentages of progressive non-alcoholic steatohepatitis in Groups A, B, C, and D were 0.0%, 7.7%, 35.7%, and 50.0%, respectively (P<0.001). The prediction model was established as logit (p) = 0.5414 × liver stiffness measurement (kPa) + 7.791 × attenuation coefficient (dB/cm/MHz)—8.401, with area under the receiver operating characteristic curve, sensitivity, and specificity values of 0.832, 80.9%, and 74.6%, respectively; there was no significant difference from the FibroScan-aspartate aminotransferase score.

Conclusion
Combined assessment by two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter is useful for risk stratification of progressive non-alcoholic steatohepatitis and may be convenient for evaluating the necessity of specialist referral and liver biopsy.
Do mothers who delivered at health facilities return to health facilities for postnatal care follow-up? A multilevel analysis of the 2016 Ethiopian Demographic and Health Survey
Authors: Ayele Brhane , Woldu Mulugeta , Gebrehiwot Haftom , Wellay Tsegay , Hadgu Tsegay , Gebretnsae Hailay , Abrha Alemnesh , Gebre-egziabher Equbay , Hurlburt Sarah 
Published: April 2021

Introduction
Returning to health facility for postnatal care (PNC) use after giving birth at health facility could reflect the health seeking behavior of mothers. However, such studies are rare though they are critically important to develop vigorous strategies to improve PNC service utilization. Therefore, this study aimed to determine the magnitude and factors associated with returning to health facilities for PNC among mothers who delivered in Ethiopian health facilities after they were discharged.

Methods
This cross-sectional study used 2016 Ethiopian Demographic and Health Survey data. A total of 2405mothers who gave birth in a health facility were included in this study. Multilevel mixed-effect logistic regression model was fitted to estimate both independent (fixed) effects of the explanatory variables and community-level (random) effects on return for PNC utilization. Variable with p-value of ≤ 0.25 from unadjusted multilevel logistic regression were selected to develop three models and p-value of ≤0.05 was used to declare significance of the explanatory variables on the outcome variable in the final (adjusted) model. Analysis was done using IBM SPSS statistics version 21.

Result
In this analysis, from the total 2405 participants, 14.3% ((95%CI: 12.1–16.8), (n = 344)) of them returned to health facilities for PNC use after they gave birth at a health facility. From the multilevel logistic regression analysis, being employed (AOR = 1.51, 95%CI: 1.04–2.19), receiving eight and above antenatal care visits (AOR = 2.90, 95%CI: 1.05–8.00), caesarean section delivery (AOR = 2.53, 95%CI: 1.40–4.58) and rural residence (AOR = 0.56, 95%CI: 0.36–0.88) were found significantly associated with return to health facilities for PNC use among women who gave birth at health facility.

Conclusion
Facility-based PNC utilization among mothers who delivered at health facilities is low in Ethiopia. Both individual and community level variables were determined women to return to health facilities for PNC use. Thus, adopting context-specific strategies/policies could improve PNC utilization and should be paid a due focus.
Food for Thought: Of Tables, Art and Women in Virginia Woolf’s To the Lighthouse
Authors: Ciobanu Estella Antoaneta 
Published: April 2021

AbstractThis article examines art as it is depicted ekphrastically or merely suggested in two scenes from Virginia Woolf’s novel To the Lighthouse, to critique its androcentric assumptions by appeal to art criticism, feminist theories of the gaze, and critique of the en-gendering of discursive practices in the West. The first scene concerns Mrs Ramsay’s artinformed appreciation of her daughter’s dish of fruit for the dinner party. I interpret the fruit composition as akin to Dutch still life paintings; nevertheless, the scene’s aestheticisation of everyday life also betrays visual affinities with the female nude genre. Mrs Ramsay’s critical appraisal of ways of looking at the fruit - her own as an art connoisseur’s, and Augustus Carmichael’s as a voracious plunderer’s - receives a philosophical slant in the other scene I examine, Lily Briscoe’s nonfigurative painting of Mrs Ramsay. The portrait remediates artistically the reductive thrust of traditional philosophy as espoused by Mr Ramsay and, like the nature of reality in philosophical discourse, yields to a “scientific” explication to the uninformed viewer. Notwithstanding its feminist reversal of philosophy’s classic hierarchy (male knower over against female object), coterminous with Lily’s early playful grip on philosophy, the scene ultimately fails to offer a viable non-androcentric outlook on life.
Ancient Roman Naval Rams as Objects of Phallic Power
Authors: DeCasien Stephen 
Published: April 2021

AbstractPolyvalent meanings behind naval ram displays were prevalent and ingrained in the Roman world, especially at Octavian’s Campsite Memorial for the Actian War. Naval rams and their display alluded to gender and power discourses within Roman society. These discourses included Roman notions of sex, penetration, domination, phallus size, and ideas of achieved hierarchies of masculinity. Analyzing ram displays through Roman perceptions of gender and sexuality, specifically concerning ancient masculinity, reveals that rams functioned not only as weapons of war but also as metaphorical phalloi that embodied and projected immense power. Octavian’s ram display at Actium was used to effeminize Marc Antony through the successful defeat and figurative castration of his fleet, which was done by cutting off the rams from the bows of the warships. By exhibiting the rams as such, Octavian asserted his own impenetrability and masculine virtue, which simultaneously promoted Antony’s penetrability and lack of masculinity. In choosing the largest rams, Octavian implied that his masculine prowess was invincible. The ram display unveiled Octavian’s phallic dominion over all other Greeks and Romans. As Octavian’s naval ram display was the largest and most impressive of the ancient world, he effectively rendered all previous ram dedications subordinate to his own.
Was There a Military Revolution at the End of Antiquity?
Authors: Whately Conor 
Published: April 2021

AbstractIn a book on Justinian’s wars of conquest, Peter Heather has argued that Rome’s ability to wage war in the sixth century CE was helped, to a large degree, by the military revolution that took place in Late Antiquity, which consisted of two principal parts: an increased deployment of Roman soldiers to the eastern frontier, and a shift towards Hunnic tactics. In this essay, however, I argue that these claims are misguided, and using five criteria set out by Lee Brice in an article on military revolution during the reigns of Philip II and Alexander the Great of Macedon, I show that the changes which Heather argues in favour of had begun long before Late Antiquity. Instead, what we see is the continued gradual evolution of Rome’s military, with the Roman state shifting troops to the east from the beginning of the imperial era, and the first documented implementation of steppe-inspired changes dating to the second century.
Probing of nonlinear impairments in long range optical transmission systems
Authors: Ali Farman , Shakeel Muhammad , Ali Asar , Shah Wajid , Qamar Muhammad Salman , Ahmad Shabbir , Ali Usman , Waqas Muhammad 
Published: April 2021

Abstract
Optical communication systems represent the backbone of modern long-haul communication networks. Nonlinear impairments such as the Kerr effect pose threat and deteriorate transmission in long-haul optical communication systems. At high launch powers, nonlinear effects become more important and their compensation is entailed to improve the transmission performance. In this paper, one of the major nonlinear effects of four waves mixing (FWM) is addressed using a theoretical model and validated through simulation in Optisystem. Two mechanisms with and without dispersion variation are investigated. The impact of FWM is investigated in terms of various values of launch power. The transmission performances of the proposed model are evaluated on the basis of bit error rate, optical signal to noise ratio, and quality factor using key parameters of effective area, nonlinear refractive index, nonlinear dispersion, and linear dispersion.
Validation of a continuous measure of cardiometabolic risk among adolescents
Authors: Li Kaigang , Haynie Denise L. , Gao Xiang , Lipsky Leah M. , Nansel Tonja , Iannotti Ronald J. , Vaca Federico E. , Simons-Morton Bruce G. 
Published: April 2021

Abstract

Objectives
We validated a continuous cardiometabolic risk (CMR) measure among adolescents.

Methods
Five metabolic syndrome (MetS) components including waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting blood glucose, and mean arterial pressure were assessed in a national cohort of U.S. adolescents (n=560; 16.5 ± 0.5 y/o at baseline) in 10th grade (2010, Wave 1 (W1)), and follow-up assessments four (W4) and seven (W7) years later. Separately by wave, linear regressions were fitted to each MetS component controlling for age, sex, and race/ethnicity, and yielded standardized residuals (Z-scores). Wave-specific component Z-scores were summed to obtain composite CMR Z-scores. Four- and seven-year CMR change (CMR-diff W1–W4 and W1–W7). and average CMR risk (CMR-avg; (W1 + W4)/2 and (W1 + W7)/2) were calculated using the CMR Z-scores. W7 MetS was determined using adult criteria. Student’s t-test and receiver operating characteristic (ROC) curve were conducted.

Results
Participants meeting the adult criteria for MetS at W7 (74 of 416, 17.8%) had statistically significant (p<0.01) higher values for W1 CMR Z-scores (0.92 vs. −0.21), W4 CMR Z-scores (1.69 vs. −0.28), W7 CMR Z-scores (2.21 vs. −0.55), W1–W4 CMR-avg (1.53 vs. −0.27), W1–W7 CMR-diff (1.29 vs. −0.21), and W1–W7 CMR-avg (1.46 vs. −0.48) than those not meeting MetS criteria. Most results were similar for males and females in the sex-stratified analyses. The areas under the ROC curve were 0.61, 0.71, and 0.75 for W1, W4 and W7 Z-scores.

Conclusions
Findings support the validity of the continuous CMR Z-scores calculated using linear regression in evaluating and monitoring CMR profiles from adolescence to early adulthood.
The genetics and clinical manifestations of patients with vitamin D dependent rickets type 1A
Authors: Ozden Ayse , Doneray Hakan 
Published: April 2021

Abstract

Objectives
Vitamin D dependent rickets type 1A (VDDR-1A) is a very rare autosomal recessive disorder caused by mutations in the CYP27B1, which encodes vitamin D 1α-hydroxylase. We report the genetics and clinical manifestations of nine patients with VDDR-1A and compare our patients to other cases with the same mutations in the literature.

Methods
The clinical presentations, clinical and laboratory findings and treatment modalities of the patients were evaluated retrospectively.

Results
The mean age of the patients at the time of diagnosis was 39.9 months (range: 4.5–111). At the time of diagnosis, six patients had received stoss vitamin D therapy. Clinical findings related to rickets were obvious in seven patients and unclear in two patients. Except for one case, all patients had laboratory findings of rickets. A novel variant and four previously reported mutations in CYP27B1 were identified. The mean calcitriol and elemental calcium dose were 45.5 ng/kg/day (range: 20–70) and 75.6 mg/kg/day (range: 45–125), respectively.

Conclusions
We found a novel compound heterozygous mutation consisting of a reported duplication [(p.F443Pfs*24 (c.1319_1325 dup CCCACCC)] in exon 8 and a novel deletion [p.D507Efs*34 (c.1521 delC)] in exon 9. Our study suggests that the clinical manifestations and laboratory findings of the patients with VDDR1A are variable even among the patients with the same mutation.
Blood pressure dynamics after pubertal suppression with gonadotropin-releasing hormone analogs followed by estradiol treatment in transgender female adolescents: a pilot study
Authors: Perl Liat , Elkon-Tamir Erella , Segev-Becker Anat , Israeli Galit , Brener Avivit , Oren Asaf 
Published: April 2021

Abstract

Objectives
The benefits of gonadotropin-releasing hormone analogues (GnRHa) in the treatment of central precocious puberty are well established, and their use is regarded as both safe and effective. Possible adverse effects on blood pressure (BP) and cardiac outcomes, body composition, bone health and brain development, however, continue to be of some concern. The aim of this study was to analyze BP changes in transgender female adolescents before and after receiving GnRHa and after adding estrogen treatment.

Methods
This was a retrospective pilot study. We analyzed systolic BP (SBP) and diastolic BP (DBP) before and after GnRHa initiation and after adding estrogen.

Results
Nineteen transgender female adolescents received GnRHa and 15 continued to estrogen treatment. Their baseline SBP and DBP percentiles did not change significantly after either GnRHa or the addition of estrogen treatment.

Conclusions
Blood pressure is apparently not affected by GnRHa or GnRHa + estrogen treatment in transgender female adolescents. Further larger studies are indicated to confirm these findings.