bluuebunny/crossref_metadata_2025_split huggingface dataset:
MXene/TMD Nanohybrid for the Development of Smart Electronic Textiles Based on Physical Electromechanical Sensors
Authors: Adepu Vivek , Kamath Krutarth , Siddhartha Sukruth , Mattela Venkat , Sahatiya Parikshit 
Published: December 2021

AbstractWearable technologies are becoming gradually prevalent as a personal health system, facilitating unceasing real‐time monitoring of human health on a regular basis and outside the clinical environments. In this perspective, an urgent requirement for extensively sensitive and wearable sensors has increased to examine health during life activities. The fabrication of Ti3C2Tx/SnSe2 nanohybrid E‐textile based multifunctional physical sensors (pressure, strain) on the cotton substrate to monitor an individual's health during daily activities is demonstrated here. The fabricated nanohybrid E‐textile based physical sensors display an extraordinary sensitivity of 14.959 kPa–1 in the applied pressure range of 1.477–3.456 kPa and a gauge factor of 14.108 for 5–25% of applied strain. In addition, these physical sensors show exceptional stability of ≈2500 cycles for a pressure sensor and ≈3000 cycles for a strain sensor which signifies the sturdiness of the sensor. Detailed underlying physics and transduction mechanism are explained by Schottky barrier and tunneling resistance mechanism. Further, an android/iOS/web‐based app is developed to validate wireless integration of the fabricated multifunctional physical sensors for demonstration toward smart shoe and crepe bandage applications.
Compact Terahertz Dielectric Folded Metasurface
Authors: Zhu Shu‐Yan , Wu Geng‐Bo , Pang Stella W. , Chan Chi Hou 
Published: December 2021

AbstractDespite modern terahertz (THz) systems benefit from the developments in metasurfaces with flexible wavefront manipulation capabilities, the large propagation space between the THz source/detector and metasurface component, as well as the inherent insertion loss of metasurfaces, are the two main bottlenecks that hinder metasurface‐based THz devices from becoming a practical technology. This article addresses these two problems by demonstrating a compact, high‐efficiency folded metasurface system in the THz band. The device comprises two parallel dielectric metasurfaces, between which the THz waves are confined to reduce the system volume. The bottom reflective metasurface consists of an array of anisotropic dielectric resonators, which can simultaneously manipulate THz waves’ phase and polarization properties. The upper metasurface is a dielectric Bragg polarizer that selects the desired linear polarization of THz waves to pass through. Low‐loss and nondispersive high‐resistivity silicon is used as the material for both metasurfaces in this design, which is essential to achieving high efficiency. The compact and high‐efficiency folded THz metasystem is further experimentally verified. The introduced folded device can be used in diverse applications such as high‐speed THz communications, non‐destructive detection, and imaging systems, significantly reducing their volume and increasing their radiation efficiency.
Ultrathin Al‐Assisted Al2O3 Passivation Layer for High‐Stability Tungsten Diselenide Transistors and Their Ambipolar Inverter
Authors: Cho Haewon , Pujar Pavan , Cho Yong In , Hong Seongin , Kim Sunkook 
Published: December 2021

Abstract2D transition metal dichalcogenides (TMDs) have recently received significant attention owing to their superior electrical, optical, and mechanical properties. However, most previous research on TMDs has not focused on their stability against bias and illumination stress. Here, high‐stability tungsten diselenide (WSe2) field‐effect transistors (FETs) are introduced with an ultrathin Al‐assisted alumina (Al2O3) passivation. Through the Al‐assisted Al2O3 passivation, the transport behavior of the WSe2 FETs is converted from p‐type to ambipolar owing to the n‐type doping effect of Al2O3 passivation. Furthermore, the stability of the WSe2 FETs is highly improved against gate bias and illumination stress owing to the effect of Al2O3 film quality on WSe2 by ultrathin Al predeposition (≈1 nm). To compare the stress effect on the electrical characteristics, three types of devices: 1) pristine WSe2 FETs, 2) WSe2 FET with Al2O3 passivation layer, and 3) WSe2 FETs with Al‐assisted Al2O3 passivation layer, are systematically tested with positive gate bias stress (PBS) and positive gate bias illumination stress (PBIS). Finally, an ambipolar inverter composed of Al‐assisted Al2O3 passivated WSe2 FETs is demonstrated. This study proposes a promising approach that improves the stability of TMD‐based FETs for next‐generation logic applications.
Solution‐Processed Chalcopyrite Solar Cells: the Grain Growth Mechanism and the Effects of Cu/In Mole Ratio
Authors: Yu Shaotang , Li Bingyan , Jiang Jingjing , Liu Xinge , Hao Shasha , Han Shuaiqi , Yan Weibo , Xin Hao 
Published: December 2021

AbstractSolution‐processed Cu(In,Ga)(S,Se)2 solar cells have reached 18% efficiency but still remain much lower compared to state‐of‐the‐art vacuum based solar cells. In comparison to vacuum deposited precursor films, which mostly consist of stacked metal and/or metal chalcogenide layers and takes a liquid Cu2−xSe assisted grain growth mechanism, solution‐processed precursor films normally have a chalcopyrite structure that is already developed. Understanding the grain growth mechanism of solution‐processed absorbers is crucial to control the electronic properties and further improve the device photovoltaic performance. Here, the grain growth mechanism of a N‐methyl‐pyrrolidone solution processed precursor film with composition from Cu‐poor to Cu‐rich is systematically investigated. Characterizations show that the chalcopyrite structured CuInS2 precursor film takes a direct phase transformation grain growth mechanism and forms the CuIn(S,Se)2 (CISSe) absorber without the presence of a detrimental Cu2−xSe phase with Cu/In ratio up to unit. Beyond the stoichiometric composition, the coexistence of Cu2−xSe facilitates grain growth but deteriorates device performance. The direct phase transformation mechanism not only avoids detrimental Cu2−xSe but also enables fabrication of a highly efficient CISSe device near stoichiometric composition with high tolerance to the Cu/In ratio (from 0.90 to 1.05). By preliminary optimization, a CISSe solar cell with an efficiency of 13.6% is achieved in ambient air with a Cu/In ratio of 0.93.
Steering the Glycerol Electro‐Reforming Selectivity via Cation–Intermediate Interactions
Authors: Wu Jianxiang , Li Jili , Li Yefei , Ma Xian‐Yin , Zhang Wei‐Yi , Hao Yaming , Cai Wen‐Bin , Liu Zhi‐Pan , Gong Ming 
Published: December 2021

AbstractElectro‐reforming of renewable biomass resources is an alternative technology for sustainable pure H2 production. Herein, we discovered an unconventional cation effect on the concurrent formate and H2 production via glycerol electro‐reforming. In stark contrast to the cation effect via forming double layers in cathodic reactions, residual cations at the anode were discovered to interact with the glycerol oxidation intermediates to steer its product selectivity. Through a combination of product analysis, transient kinetics, crown ether trapping experiments, in situ IRRAS and DFT calculations, the aldehyde intermediates were discovered to be stabilized by the Li+ cations to favor the non‐oxidative C−C cleavage for formate production. The maximal formate efficiency could reach 81.3 % under ≈60 mA cm−2 in LiOH. This work emphasizes the significance of engineering the microenvironment at the electrode–electrolyte interface for efficient electrolytic processes.
Highly Regio‐ and Enantioselective Hydrosilylation of gem‐Difluoroalkenes by Nickel Catalysis
Authors: Bai Dachang , Wu Fen , Chang Lingna , Wang Manman , Wu Hao , Chang Junbiao 
Published: December 2021

AbstractThe synthesis of small organic molecules with a difluoromethylated stereocenter is particularly attractive in drug discovery. Herein, we have developed an efficient method for the direct generation of difluoromethylated stereocenters through Ni0‐catalyzed regio‐ and enantioselective hydrosilylation of gem‐difluoroalkenes. The reaction also represents the enantioselective construction of carbon(sp3)−silicon bonds with nickel catalysis, which provides an atom‐ and step‐economical synthesis route of high‐value optically active α‐difluoromethylsilanes. This protocol features readily available starting materials and commercial chiral catalysis, broad substrates spanning a range of functional groups with high yield (up to 99 % yield) and excellent enantioselectivity (up to 96 % ee). The enantioenriched products undergo a variety of stereospecific transformations. Preliminary mechanistic studies were performed.
Radikalische 1‐Fluorsulfonyl‐2‐alkinylierung von nicht aktivierten Alkenen
Authors: Frye Nils Lennart , Daniliuc Constantin G. , Studer Armido 
Published: December 2021

AbstractSulfonylfluoride haben in der chemischen Biologie und der Arzneimittelforschung breite Anwendung gefunden. Die Entwicklung von Synthesemethoden zur Einführung der Sulfonylfluorideinheit ist daher von hoher Relevanz. In dieser Zuschrift wird eine übergangsmetallfreie radikalische 1,2‐Difunktionalisierung von nicht aktivierten Alkenen über radikalische FSO2‐Addition mit anschließender vicinaler Alkinylierung vorgestellt, um β‐Alkinylfluorsulfonylalkane zu erhalten. Alkinylsulfonylfluoride werden als sehr wertvolle bifunktionelle Reagenzien zum Einfangen von Radikalen vorgestellt, die gleichzeitig auch als Vorläufer für FSO2‐Radikale dienen. Die bei diesen Transformationen anfallenden β‐Alkinylfluorsulfonylalkane können über SuFEx‐Click‐Chemie leicht weiter diversifiziert werden, um Sulfonate und Sulfonamide zu erhalten.
Radical 1‐Fluorosulfonyl‐2‐alkynylation of Unactivated Alkenes
Authors: Frye Nils Lennart , Daniliuc Constantin G. , Studer Armido 
Published: December 2021

AbstractSulfonyl fluorides have found widespread use in chemical biology and drug discovery. The development of synthetic methods for the introduction of the sulfonyl fluoride moiety is therefore of importance. Herein, a transition‐metal‐free radical 1,2‐difunctionalization of unactivated alkenes via FSO2‐radical addition with subsequent vicinal alkynylation to access β‐alkynyl‐fluorosulfonylalkanes is presented. Alkynyl sulfonyl fluorides are introduced as highly valuable bifunctional radical trapping reagents that also serve as FSO2‐radical precursors. The β‐alkynyl‐fluorosulfonylalkanes obtained in these transformations can be readily diversified by using SuFEx click chemistry to obtain sulfonates and sulfonamides.
Effects of different nitrogen doses on thymoquinone and fatty acid composition in seed oil of black cumin (Nigella sativa L.)
Authors: Telci Isa , Izgi Mehmet Necat , Ozek Temel , Yasak Selma , Yur Suleyman , Ozek Gulmira 
Published: December 2021

AbstractBlack cumin, Nigella sativa L. belonging to Ranunculaceae, is a valuable medicinal plant because of the curative effects of seed and oil. Despite studies on black cumin, there are few studies on the effects of nitrogen on fatty acid composition, no records on thymoquinone yield, and the thymoquinone content of the seed oil. In this study, the effects of different nitrogen doses on the seed oil yield, thymoquinone ratio/yield, and fatty acid compositions were investigated. Field studies with nitrogen doses (0, 40, 60, 80, and 100 kg/ha) were studied using the randomized plot design. As a result of the research, nitrogen doses significantly affected the oil and thymoquinone yields while insignificant on the thymoquinone ratio. The highest oil yield with 501.6 kg/ha was obtained from 80 kg/ha of the nitrogen doses, while the highest thymoquinone yield with 10.24 kg/ha was obtained from the control plots. Thymoquinone yields were in the same statistical group with other nitrogen doses, except for means of 100 kg/ha nitrogen doses. Linoleic, oleic, and palmitic acids were major fatty acids of black cumin, and their variations were insignificant in nitrogen applications. The values of butyric, capric, and linolenic acids varied significantly in different nitrogen doses. As a result of the study, it was determined that the highest oil yield was obtained from 80 kg/ha nitrogen application. It has been determined that nitrogen doses above 60–80 kg/ha should be avoided for the seed oil and thymoquinone yields in black cumin.
Design and synthesis of novel quinazolinone‐based fibrates as PPARα agonists with antihyperlipidemic activity
Authors: Hassan Rasha M. , Ali Islam H. , Abdel‐Maksoud Mohammed S. , Abdallah Heba M. I. , El Kerdawy Ahmed M. , Sciandra Francesca , Ghannam Iman A. Y. 
Published: December 2021

AbstractAiming to discover new antihyperlipidemic agents, a new set of quinazolinone‐fibrate hybrids 9a–r bearing the essential features for peroxisome proliferator‐activated receptor‐α (PPARα) agonistic activity was synthesized and the structures were confirmed by different spectral data. All the target compounds were screened for their PPARα agonistic activity. Compounds 9o and 9q exhibited potent activity, with EC50 values better than that of fenofibrate by 8.7‐ and 27‐fold, respectively. Molecular docking investigations were performed for all the newly synthesized compounds in the active site of the PPARα receptor to study their interactions and energies in the receptor. Moreover, the antihyperlipidemic and antioxidant activities of compounds 9o and 9q were determined using Triton WR‐1339‐induced hyperlipidemic rats. Compound 9q exhibited effective hypolipidemic activity in a dose‐dependent manner, where it significantly reduced the serum levels of total cholesterol, triglycerides, low‐density lipoprotein cholesterol, and very‐low‐density lipoprotein cholesterol and increased the level of high‐density lipoprotein cholesterol. Furthermore, it possesses a powerful antioxidant profile where it significantly elevated the levels of reduced glutathione as well as the total antioxidant capacity and significantly decreased the malondialdehyde level. The histopathological studies revealed that compound 9q improved the aortic architecture and hepatic steatosis. These findings support that compound 9q could be a promising lead compound for the development of new antihyperlipidemic agents.
Eugenol carbonate activity against Plasmodium falciparum, Leishmania braziliensis, and Trypanosoma cruzi
Authors: Clemente Camila M. , Pineda Tatiana , Yepes Lina M. , Upegui Yulieth , Allemandi Daniel A. , Robledo Sara M. , Ravetti Soledad 
Published: December 2021

AbstractNeglected tropical diseases are a major health problem throughout the world, and there are few effective and safe drugs. In this study, we report the design and synthesis of a novel series of carbonates of eugenol using different aliphatic alcohols and N,N‐carbonyldiimidazole. Spectroscopic techniques, including 1H nuclear magnetic resonance (NMR), 13C NMR, Fourier transform infrared, and high‐resolution mass spectrometry, were used to confirm the structures of the synthesized compounds. In vitro and in silico studies of prodrugs of eugenol were performed to determine their antiplasmodial, trypanocidal, and leishmanicidal activities, and also their cytotoxicity. Compounds were highly active against Leishmania braziliensis and Plasmodium falciparum, whereas the activity shown for Trypanosoma cruzi was moderate. Molecular docking was used to determine a possible mode of action of eugenol against the dihydroorotate dehydrogenase of the three parasites (TcDHODH, LbDHODH, and PfDHODH). Notably, the docking results showed that eugenol not only has binding energy similar to that of the natural substrate (−7.2 and −7.1, respectively) but also has interactions with relevant biological residues of PfDHODH. This result indicates that eugenol could act as a substrate for PfDHODH in the pyrimidine biosynthesis pathway of P. falciparum. In conclusion, the combination of certain aliphatic alcohols and eugenol through a carbonate bond could significantly increase the antiparasitic activity of this class of compounds, which merits further studies.
A rotating bioreactor for the production of biofilms at the solid–air interface
Authors: Kretschmer Martin , Hayta Elif N. , Ertelt Marvin J. , Würbser Michaela A. , Boekhoven Job , Lieleg Oliver 
Published: December 2021

AbstractConventional bioreactors are typically developed for the production of planktonic bacteria or submerged biofilms. In contrast, reactors for the continuous production of biofilms at the solid–air interface are scarce, and they require specific conditions since the bacteria need to attach firmly to the surface and require a permanent supply of moisture and nutrients from below. Recently, research from the field of civil engineering has pinpointed an increased need for the production of terrestrial biofilms: several variants of Bacillus subtilis biofilms have been shown to be useful additives to mortar that increase the water repellency, and, thus, the lifetime of the cementitious material. The bioreactor introduced here allows for the continuous production of such bacterial biofilms at the solid‐air interface, and they have virtually identical properties as biofilms cultivated via classical microbiological techniques. This is made possible by equipping a rotating cylinder with a porous membrane that acts as a solid growth substrate the bacterial biomass can form on. In this configuration, nutrient supply is enabled via diffusive transport of a suitable growth medium from the core volume of the cylindrical reactor to the membrane surface. In addition to cultivating bacterial biofilms, the versatile and adaptable set up introduced here also enables the growth of other microbial organisms including the yeast Saccharomyces cerevisiae and the fungus Penicillium chrysogenum.
Stakeholders' engagement in the business strategy as a key driver to increase companies' performance: Evidence from managerial and stakeholders' practices
Authors: Hristov Ivo , Appolloni Andrea 
Published: December 2021

AbstractStakeholders' engagement at a strategic level represents one of the key dimensions that affects companies' performance, directly impacting on the decision‐making process. Despite many theoretical studies focused on the relevant role of stakeholders' engagement in the value creation process of organizations, many issues are not adequately addressed in managerial practices. Based on a multiple case study with 61 Italian companies from different sectors, (1) we explore the main strategic dimensions and connected value drivers that affect stakeholders' perception, and (2) we illustrate a suitable way to strategically integrate stakeholders' perception drivers in the performance management system (PMS) implementation. According to the contribution of the managers and selected stakeholders of the companies involved in the study, we propose a framework to support a more comprehensive development of the key dimensions that influence stakeholders' engagement (sustainable development, organizational drivers, cultural context, and digital transformation) at a strategic level.
Selective Immobilization of His‐Tagged Phosphomannose Isomerase on Ni Chelated Nanoparticles with Good Reusability and Activity
Authors: Wang Kangjing , Zhao Liting , Li Ting , Wang Qian , Ding Zhongyang , Dong Weifu 
Published: December 2021

AbstractSelf‐stable precipitation polymerization was used to prepare an enzyme‐immobilized microsphere composite. Phosphomannose isomerase (PMI) with His‐tag was successfully immobilized on Ni2+ charged pyridine‐derived particles. The maximum amount of PMI immobilized on such particles was ∼184 mg/g. Compared with free enzyme, the activity of the immobilized enzymes was significantly improved. In addition, the immobilized enzymes showed a much better thermostability than free enzymes. At the same time, the immobilized enzymes can be reused for multiple reaction cycles. We observed that the enzyme activity did not decrease significantly after six cycles. We conclude that the pyridine‐derived particles can be used to selectively immobilize His‐tagged enzymes, which can couple the enzyme purification and catalysis steps and improve the efficiency of enzyme‐catalyzed industrial processes.
DNA Origami‐Based Protein Manipulation Systems: From Function Regulation to Biological Application
Authors: Xu Ziqi , Huang Yide , Yin Hao , Zhu Xurong , Tian Ye , Min Qianhao 
Published: December 2021

AbstractProteins directly participate in tremendous physiological processes and mediate a variety of cellular functions. However, precise manipulation of proteins with predefined relative position and stoichiometry for understanding protein‐protein interactions and guiding cellular behaviors is still challenging. With superior programmability of DNA molecules, DNA origami technology is able to construct arbitrary nanostructures that can accurately control the arrangement of proteins with various functionalities to solve these problems. Herein, starting from the classification of DNA origami nanostructures and the category of assembled proteins, we summarize the existing DNA origami‐based protein manipulation systems (PMSs), review the advances on the regulation of their functions, and discuss their applications in cellular behavior modulation and disease therapy. Moreover, the limitations and potential directions of DNA origami‐based PMSs are also presented, which may offer guidance for rational construction and ingenious application.
NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells
Authors: Li Tiantian , Li Xu , Mao Rongchen , Pan Lihua , Que Yuhui , Zhu Chao , Jin Lai , Li Shengnan 
Published: December 2021

AbstractNucleotide‐binding oligomerization domain‐like receptors (NLRs) are crucial types of innate immune sensors and well known for their critical roles in the immune system. However, how NLRP2 functions in the progression of cancer is largely unknown. Here, we identified NLRP2 as an antioncogene in lung adenocarcinoma (LUAD) cells. Gain‐ and loss‐of‐function studies revealed that NLRP2 silencing promoted cell proliferation and migration by stimulating NF‐kB signaling in the microenvironment, which induced epithelial‐to‐mesenchymal transition (EMT) phenotype and cytoskeleton reorganization in LUAD cells. The addition of the NF‐kB inhibitor rescued the function of NLRP2 on EMT. Moreover, NLRP2 increased the level of cofilin phosphorylation and repressed subsequent F‐actin reorganization. Consistently, the in vivo study showed that NLRP2 played an inhibitory role in forming metastasis foci. Taken together, NLRP2 inhibited cell proliferation and migration by regulating EMT in LUAD cells, demonstrating the essential function of NLRP2 in the development of LUAD.
Endotracheal cuff undersizing diagnosed by computed tomography: Case report
Authors: Wu Hong‐Lei , Zhang Yan‐Man , Shi Jia‐hai , Ji Pei‐pei , Shen Wang‐Qin 
Published: December 2021

AbstractWe herein report a case in which the trachea could be completely sealed only when the cuff pressure reached 100 cmH2O. An excessive cross‐sectional area of the trachea is a rare phenomenon, but we believe that our case will be helpful for clinicians who encounter similar situations.
Splenosis mimicking gastric obstructive tumor: Diagnostic workup and surgical excision
Authors: Rompou Vaia‐Aliki , Korkolis Dimitrios , Skafida Evelina , Tsamis Dimitrios , Plastiras Aris 
Published: December 2021

AbstractSplenosis is a condition that occurs after splenic rupture. A 29‐year‐old male patient with a history of splenectomy was admitted due to multiple vomiting episodes. The diagnostic workup was unable to differentiate between gastric GIST and splenosis. Laparoscopic surgical resection was performed leading to the diagnosis of splenosis.