bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking the biology of metastatic melanoma: a holistic approach
Authors: Vandyck Hendrik HLD , Hillen Lisa M , Bosisio Francesca M , van den Oord Joost , zur Hausen Axel , Winnepenninckx Véronique 
Published: April 2021

AbstractOver the past decades, melanoma-related mortality has remained nearly stable. The main reason is treatment failure of metastatic disease and the inherently linked knowledge gap regarding metastasis formation. In order to elicit invasion, melanoma cells manipulate the tumor microenvironment, gain motility, and adhere to the extracellular matrix and cancer-associated fibroblasts. Melanoma cells thereby express different cell adhesion molecules like laminins, integrins, N-cadherin, and others. Epithelial-mesenchymal transition (EMT) is physiological during embryologic development, but reactivated during malignancy. Despite not being truly epithelial, neural crest-derived malignancies like melanoma share similar biological programs that enable tumorigenesis, invasion, and metastasis. This complex phenomenon is termed phenotype switching and is intertwined with oncometabolism as well as dormancy escape. Additionally, it has been shown that primary melanoma shed exosomes that create a favorable premetastatic niche in the microenvironment of secondary organs and lymph nodes. Although the growing body of literature describes the aforementioned concepts separately, an integrative holistic approach is missing. Using melanoma as a tumor model, this review will shed light on these complex biological principles in an attempt to clarify the mechanistic metastatic pathways that dictate tumor and patient fate.
Do fires discriminate? Socio-economic disadvantage, wildfire hazard exposure and the Australian 2019–20 ‘Black Summer’ fires
Authors: Akter Sonia , Grafton R. Quentin 
Published: April 2021

AbstractWe examine the relationship between socio-economic disadvantage and exposure to environmental hazard with data from the catastrophic 2019–2020 Australian wildfires (Black Summer) that burnt at least 19 million hectares, thousands of buildings and was responsible for the deaths of 34 people and more than one billion animals. Combining data from the National Indicative Aggregated Fire Extent (NIAFE) and 2016 Socio-Economic Indexes for Areas (SEIFA), we estimate the correlation between wildfire hazard exposure and an index of community-level socio-economic disadvantage. Wildfire hazard exposure is measured as the interaction between the percentage of area burnt and proximity of the fire to settlements. The results reveal a significant positive relationship between fire hazard exposure and socio-economic disadvantage, such that the most socio-economically disadvantaged communities bore a disproportionately higher hazard exposure in the Black Summer than relatively advantaged communities. Our spatial analysis shows that the socio-economic disadvantage and wildfire hazard exposure relationship exists in inner regional, outer regional and remote areas of New South Wales and Victoria, the two worst-hit states of the Black Summer catastrophe. Our spatial analysis also finds that wildfire hazard exposure, even within a small geographical area, vary substantially depending on the socio-economic profiles of communities. A possible explanation for our findings is resource gaps for fire suppression and hazard reduction that favour communities with a greater level of socio-economic advantage.
Metal accumulations in aquatic organisms and health risks in an acid mine-affected site in South China
Authors: Chan Wing Sze , Routh Joyanto , Luo Chen , Dario Mårten , Miao Yuqing , Luo Dinggui , Wei Lezhang 
Published: April 2021

AbstractMetal contamination from base metal sulphide mines is a major environmental challenge that poses many ecological and health risks. We examined the metal concentrations in the Dabaoshan mine in South China in water, sediments, and aquatic organisms and their specific characteristics (i.e. size, body tissue, species, and habitat) along the Hengshi and Wengjiang River courses to assess acid mine drainage remediation efforts. Metal concentrations of arsenic, cadmium, chromium, copper, lead, nickel, thallium, and zinc were examined in tissues (i.e. gills, intestines, and muscles) of 17 freshwater species of fish, shrimps, and crabs. Metals in tissues followed the trend: intestines > gills > muscles; nearly all intestine samples exceeded the safe limits of metals analysed in this study. There is a positive correlation between distance from the mine and metal concentrations related to the flow of surface water and the habitat of aquatic organisms. The concentrations of arsenic, copper, and zinc were the highest in aquatic organisms, and the distribution was influenced by physical (distance from mine, currents, and seasonality), chemical (pH and competing ions), and biological (species, habitat, and predator–prey relation) factors. Large demersal fish and benthic fauna had higher concentrations of metals. Bioaccumulation and biomagnification of metals, as well as the high metal pollution index and target hazard quotient (arsenic, cadmium, copper, lead, thallium, and zinc), occurred in bottom feeders (C. aumtus, X. argentea) and fish belonging to higher trophic levels (P. fulvidraco, O. mossambicus). Lead and cadmium indicated the highest level of biomagnification from prey to predator. Health risks exist from the dietary intake of common aquatic species such as tilapia and carp besides crustaceans due to high arsenic, cadmium, lead, and thallium levels. Further reduction of metals is necessary to improve the effects of acid mine drainage in the catchment.
Licensed professions: a new look at the association between social origins and educational attainments in Italy
Authors: Ruggera Lucia 
Published: April 2021

AbstractIt has long been known that Italy is characterized by the highest levels of professional regulation in Europe, but little attention has been given to the link between professional regulation and educational stratification. This article investigates the association between social origins and education by focusing on fields of study within tertiary education and by disaggregating the upper class of social origin into different micro-classes of professionals. Thus, since these professions are regulated in the first place by educational fields of study, it assesses how processes of social closure enhance occupational intergenerational immobility in the professional employment in Italy. Recently, deregulation of liberal professions in Italy has been central in many public and political debates. It contributes to these debates by examining the micro-level dynamics in the professionals’ social reproduction and related practises of social exclusion, which may have strong implications for policy interventions. By using ISTAT’s “Sbocchi Professionali dei Laureati” survey (2011), and employing multinomial logistic regressions, it shows how social selection into highly regulated fields of study is guided by parents’ professional domain. The analyses indicate that both sons and daughters of licensed professionals are more inclined to graduate in a field of study that is in line with the father’s profession and that this propensity is stronger among children of regulated self-employed professionals.
Introduction to Harold Garfinkel's Ethnomethodological "Misreading" of Aron Gurwitsch on the Phenomenal Field
Authors: Eisenmann Clemens , Lynch Michael 
Published: April 2021

AbstractThis article is the editors’ introduction to the transcript of a lecture that Harold Garfinkel delivered to a seminar in 1993. Garfinkel extensively discusses the relevance of Aron Gurwitsch’s phenomenological treatment of Gestalt theory for ethnomethodology. Garfinkel uses the term “misreading” to signal a respecification of Gurwitsch’s phenomenological investigations, and particularly his conceptions of contextures, functional significations, and phenomenal fields, so that they become compatible with detailed observations and descriptions of social actions and interactions performed in situ. Garfinkel begins with Gurwitsch’s demonstrations with line drawings and other abstract examples, and suggests how they can be used to suggest original procedures for investigating the vicissitudes of embodied practical actions in the lifeworld. This introduction to the lecture aims to provide some background on the scope of Gurwitsch’s phenomenological critique and elaboration of Gestalt theory and Garfinkel’s “misreading” of it in terms of his own conceptions of indexicality and accountability, and ethnomethodological investigations of the production of social order.
The Need for Equitable Scholarship Criteria for Part-Time Students
Authors: Ardissone Alexandria N. , Galindo Sebastian , Wysocki Allen F. , Triplett Eric W. , Drew Jennifer C. 
Published: April 2021

AbstractCurrent policies and interventions to enhance student success and retention are often tied to full-time enrollment, which are substantiated by studies associating part-time enrollment with lower retention and poorer academic outcomes. However, these findings are limited to studies of first-time college students and do not represent today’s nontraditional undergraduate who may be transfer, online, and working adult students. To enhance retention of on-campus and hybrid online 2 + 2 transfer students in a STEM undergraduate program, need-based scholarships are awarded to students enrolled full-time as stipulated by the federal granting agency. Although the scholarship has helped >80 students to date, over 40% of eligible transfer students are excluded only because they are enrolled part-time, disproportionately affecting students in the hybrid online track who are more likely to be women and underrepresented minorities. Using quantitative and qualitative methods, this study explores enrollment behavior of transfer students (online and on-campus), its relationship with student characteristics and academic outcomes, and implications for scholarship eligibility. Full-time enrollment is a significant challenge for transfer students. While scholarship requirements are a key factor influencing full-time enrollment, online transfer students additionally cite work and family obligations as drivers of enrollment behavior. Thus, online 2 + 2 transfer students face different challenges than on-campus peers and are more likely to enroll part-time out of necessity, yet still have comparable GPA and graduation rates. These findings support a growing awareness of barriers nontraditional students face questioning the relevance of policies driven by “traditional” student outcomes, which perpetuate inequity in higher education.
FID-Net: A versatile deep neural network architecture for NMR spectral reconstruction and virtual decoupling
Authors: Karunanithy Gogulan , Hansen D. Flemming 
Published: April 2021

AbstractIn recent years, the transformative potential of deep neural networks (DNNs) for analysing and interpreting NMR data has clearly been recognised. However, most applications of DNNs in NMR to date either struggle to outperform existing methodologies or are limited in scope to a narrow range of data that closely resemble the data that the network was trained on. These limitations have prevented a widescale uptake of DNNs in NMR. Addressing this, we introduce FID-Net, a deep neural network architecture inspired by WaveNet, for performing analyses on time domain NMR data. We first demonstrate the effectiveness of this architecture in reconstructing non-uniformly sampled (NUS) biomolecular NMR spectra. It is shown that a single network is able to reconstruct a diverse range of 2D NUS spectra that have been obtained with arbitrary sampling schedules, with a range of sweep widths, and a variety of other acquisition parameters. The performance of the trained FID-Net in this case exceeds or matches existing methods currently used for the reconstruction of NUS NMR spectra. Secondly, we present a network based on the FID-Net architecture that can efficiently virtually decouple 13Cα-13Cβ couplings in HNCA protein NMR spectra in a single shot analysis, while at the same time leaving glycine residues unmodulated. The ability for these DNNs to work effectively in a wide range of scenarios, without retraining, paves the way for their widespread usage in analysing NMR data.
Sex Pheromone of the Alfalfa Plant Bug, Adelphocoris lineolatus: Pheromone Composition and Antagonistic Effect of 1-Hexanol (Hemiptera: Miridae)
Authors: Koczor Sándor , Vuts József , Caulfield John C. , Withall David M. , Sarria André , Pickett John A. , Birkett Michael A. , Csonka Éva Bálintné , Tóth Miklós 
Published: April 2021

AbstractThe sex pheromone composition of alfalfa plant bugs, Adelphocoris lineolatus (Goeze), from Central Europe was investigated to test the hypothesis that insect species across a wide geographical area can vary in pheromone composition. Potential interactions between the pheromone and a known attractant, (E)-cinnamaldehyde, were also assessed. Coupled gas chromatography-electroantennography (GC-EAG) using male antennae and volatile extracts collected from females, previously shown to attract males in field experiments, revealed the presence of three physiologically active compounds. These were identified by coupled GC/mass spectrometry (GC/MS) and peak enhancement as hexyl butyrate, (E)-2-hexenyl butyrate and (E)-4-oxo-2-hexenal. A ternary blend of these compounds in a 5.4:9.0:1.0 ratio attracted male A. lineolatus in field trials in Hungary. Omission of either (E)-2-hexenyl-butyrate or (E)-4-oxo-2-hexenal from the ternary blend or substitution of (E)-4-oxo-2-hexenal by (E)-2-hexenal resulted in loss of activity. These results indicate that this Central European population is similar in pheromone composition to that previously reported for an East Asian population. Interestingly, another EAG-active compound, 1-hexanol, was also present in female extract. When 1-hexanol was tested in combination with the ternary pheromone blend, male catches were reduced. This compound showed a dose-response effect with small doses showing a strong behavioral effect, suggesting that 1-hexanol may act as a sex pheromone antagonist in A. lineolatus. Furthermore, when (E)-cinnamaldehyde was field tested in combination with the sex pheromone, there was no increase in male catch, but the combination attracted both males and females. Prospects for practical application are discussed.
The influence of in-group and out-group favouritism on the disciplinary practice of ethnic majority and minority preservice teachers
Authors: Schuchart Claudia , Glock Sabine , Dunkake Imke 
Published: April 2021

AbstractTeacher judgments and the disciplinary sanctioning of pupils can be understood as a function of the ethnic match, which means whether or not teachers and pupils have the same ethnic background. According to social identity theory, teachers should be motivated to protect positive self-esteem and therefore favour pupils of their ethnic in-group over pupils of their ethnic out-group. Following system justification theory however, it must be assumed that teachers also base their judgments and their disciplinary behaviour on the acceptance of social hierarchies. According to this theory, ethnic minority teachers should therefore favour ethnic majority pupils over ethnic minority pupils. We test these hypotheses by conducting an experimental study among 196 preservice teachers. The results suggest that ethnic majority participants do not discriminate against ethnic minority pupils. However, although ethnic minority participants seem to explicitly favour their in-group, they also implicitly tend to have more negative stereotypes about them. Moreover, the more negative explicit and implicit stereotypes ethnic minority participants have against pupils of their in-group, the more severely they punish pupils of their out-group. This could suggest that ethnic minority participants felt the desire to compensate for a negative view of their in-group by treating their out-group more harshly.
A new paradox and the reconciliation of Lorentz and Galilean transformations
Authors: Guo Hongyu 
Published: April 2021

AbstractOne of the most debated problems in the foundations of the special relativity theory is the role of conventionality. A common belief is that the Lorentz transformation is correct but the Galilean transformation is wrong (only approximately correct in low speed limit). It is another common belief that the Galilean transformation is incompatible with Maxwell equations. However, the “principle of general covariance” in general relativity makes any spacetime coordinate transformation equally valid. This includes the Galilean transformation as well. This renders a new paradox. This new paradox is resolved with the argument that the Galilean transformation is equivalent to the Lorentz transformation. The resolution of this new paradox also provides the most straightforward resolution of an older paradox which is due to Selleri in (Found Phys Lett 10:73–83, 1997). I also present a consistent electrodynamics formulation including Maxwell equations and electromagnetic wave equations under the Galilean transformation, in the exact form for any high speed, rather than in low speed approximation. Electrodynamics in rotating reference frames is rarely addressed in textbooks. The presented formulation of electrodynamics under the Galilean transformation even works well in rotating frames if we replace the constant velocity $$\mathbf {v}$$
v
with $$\mathbf {v}=\varvec{\omega }\times \mathbf {r}$$

v
=

ω

×
r

. This provides a practical tool for applications of electrodynamics in rotating frames. When electrodynamics is concerned, between two inertial reference frames, both Galilean and Lorentz transformations are equally valid, but the Lorentz transformation is more convenient. In rotating frames, although the Galilean electrodynamics does not seem convenient, it could be the most convenient formulation compared with other transformations, due to the intrinsic complex nature of the problem.
Genotype-dependent mass somatic embryogenesis: a chance to recover extinct populations of Pulsatilla vulgaris Mill.
Authors: Żabicka Justyna , Żabicki Piotr , Słomka Aneta , Jędrzejczyk-Korycińska Monika , Nowak Teresa , Sliwinska Elwira , Kapler Adam , Migdałek Grzegorz , Kuta Elżbieta 
Published: April 2021

Abstract
The paper presents a technique for micropropagation of endangered in Europe and extinct in Poland Pulsatilla vulgaris for ex situ conservation of the genetic resources. Genotype-dependent induction of somatic embryogenesis and rooting was revealed in series of two experiments (I and II) performed under the same experimental conditions. Shoot tips of seedlings were the best explants in both experiments and Murashige and Skoog (MS) medium supplemented with 0.25 or 0.5 mg L−1 BAP was suitable for induction of somatic embryos (SE) and adventitious shoots. Mass SE was obtained in experiment I after explants transfer on ½ MS (2% sucrose) + 0.45 mg L−1 B1 and extending culture to 2–3 months without passages. Rooting of adventitious shoots was a critical point. Out of seven rooting media used in experiment I, only two, ½ MS hormone free (2% sucrose) + 0.45 mg L−1 B1 or MS + 5 mg L−1 NAA + 3.76 mg L−1 B2 resulted in altogether 36.4% rooted shoots. In experiment II, somatic embryogenesis, rooting and acclimatization of adventitious shoots failed. Regenerated plantlets and seedlings converted from SE from experiment I were acclimatized to ex vitro conditions. Both genome size, determined by flow cytometry, and genetic diversity analyzed by ISSR markers, confirmed the compatibility of regenerants from experiment I with P. vulgaris initial seedlings and commercial cultivar. Regenerants obtained in experiment II differed genetically from the regenerants of experiment I and cultivar. Propagated in vitro tissues/organs (SE, adventitious shoots) of P. vulgaris could be a source of material for cryopreservation, artificial seed production and/or for acclimatization of regenerated plantlets and could be used for restoration of the extinct populations.

Key Message
The micropropagation technique via organogenesis and somatic embryogenesis of endangered in Europe pasqueflower was developed as a tool for species recovery. The critical point is that somatic embryogenesis is genotype-dependent, which affects the repeatability of the experiments and also imposes applying molecular techniques to confirm the genetic fidelity of the regenerants with the initial material and other genotypes.
Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?
Authors: Carter Sophie E. , Draijer Richard , Stewart Claire E. , Moss Andy D. , Thijssen Dick H. J. , Hopkins Nicola D. 
Published: April 2021

Abstract
Purpose
Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition.

Methods
Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m−2) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses.

Results
Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (p < 0.05), MCAv reduced (∆-2.9 cm∙s−1, p = 0.012) and normalised gain increased in the very low frequency range, indicating impaired CA (∆ + 0.22%·mmHg−1, p = 0.016). Positive affect (∆-4.6, p < 0.001), and alert (∆-10.6 p = 0.002) and contented (∆-7.4, p = 0.006) mood states also decreased following sitting. No significant changes in interleukin-6, tumour necrosis factor-alpha, von Willebrand factor, CVR or cognitive performance were observed (p > 0.05). The observed changes in inflammation and cerebrovascular function were not related to changes in mood (p > 0.05).

Conclusion
Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances.