bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gangguan Neuropsikiatri Paska Kemoterapi Ifosfamid
Authors: Septiantoro Bayu Prio , Perwitasari Dyah Aryani , Farida Imaniar Noor 
Published: March 2021

Latar belakang: Reaksi obat yang merugikan (adverse drug reaction) sering muncul salah satunya pada obat-obat sitostatika. Ifosfamid adalah obat sitostatika golongan pengalkil yang ketika dimetabolisme akan membentuk senyawa aktif nitrogen mustard sitotoksik. Selain itu ia juga membentuk senyawa lain yaitu akrolein dan kloroasetaldehid. Akrolein yang bersifat urotoksik ini dengan mudah akan diikat oleh mesna, sedangkan kloroasetaldehid bersifat neurotoksik yang hingga sampai saat ini masih menjadi masalah karena keterbatasan panduan untuk anti dotumnya.
Kasus: Kami mendeskripsikan 3 pasien dengan diagnosis berbeda yang mengalami gangguan neuropsikiatri paska kemoterapi ifosfamid yaitu kanker saluran empedu dengan mengantuk berat, kanker ovarium residif dengan halusinasi, dan tumor ganas pelvis dengan penurunan kesadaran disertai kejang.
Pembahasan: Gangguan neuropsikiatri dapat disebabkan oleh neurotoksisitas dari hasil metabolisme dari ifosfamid yaitu kloroasetaldehid yang secara langsung maupun tidak langsung merusak neuron (neurotoksik). Manifestasi klinisnya dapat bertingkat mulai dari kebingungan dan mengantuk hingga kejang, koma dan kematian. Onset munculnya gejala terutama hitungan jam hingga 2 hari setelah kemoterapi selesai. Terdapat faktor resiko munculnya neurotoksisitas yang teridentifikasi pada laporan kasus ini yaitu gangguan fungsi ginjal dan hipoalbumin. Beberapa penelitian mengatakan bahwa toksistas ini berifat reversible, demikian juga dengan pasien kasus pertama yang membaik setelah 24 jam, dan kasus kedua yang membaik setelah 5 hari, namun pemberian terapi spesifik tetap direkomendasikan pada NCI stadium III atau IV.
Kesimpulan: Gangguan neuropsikiatri paska kemoterapi ifosfamid dapat disebabkan oleh neurotoksisitas pada SSP akibat kloroasetaldehid dengan faktor resiko yaitu gangguan fungsi ginjal dan hipoalbumin. Diperlukan penelitian lebih lanjut untuk memastikan bahwa gejala neuropsikiatri yang muncul adalah murni karena ifosfamid, misalnya dengan melakukan pengukuran kadar obat di dalam darah.
Sikap Remaja Tentang Pendidikan Seks Dalam Menghadapi Pubertas di Posyandu Remaja Desa Lang - Lang Kecamatan Singosari Kabupaten Malang
Authors: Galifatma Sheffi Adina Hestya 
Published: March 2021

: Problem pubertas merupakan masalah yang muncul saat terjadi perubahan fisik maupun psikologis pada remaja, pendidikan seks merupakan salah satu upaya mengatasi masalah – maslaah pada remaja dalam mengalami pubertas, akan tetapi pendidikan seks pada remaja masih menimbulkan fenomena, lantaran adanya anggapan membicarakan seks/pubertas (menstruasi) masih dianggap tabu dan mendorong remaja untuk mencoba – coba. Penelitian ini bertujuan untuk mengetahui gambaran sikap remaja tentang pendidikan seks dalam menghadapi pubertas diposyandu remaja desa Lang – Lang kecamatan Singosari kabupaten Malang. Desain penelitian ini Deskriptif Survey dengan pendekatan Cross Sectional. Populasi remaja putri 26 orang, sampel 26 responden, teknik sampling dengan cara total sampling, pengumpulan data dengan kuesioner, data disajikan dengan menggunakan distribusi frekuensi., teknik analisis menggunakan skala likert. Dari hasil penelitian ini didapatkan 69.23% bersikap positif dan 30.77% bersikap negatif. Kesimpulan yang didapat bahwa sebagian besar responden mendukung adanya pendidikan seks karena responden memahami yang dimaksud pendidikan seks adalah membimbing dan menjelaskan tentang perubahan fungsi organ seksual. Sehingga memungkinkan responden mengetahui pentingnya pendidikan seks bagi remaja. Selain itu, dikarenakan sebagian responden mengakui sebagai remaja membutuhkan informasi tentang pendidikan seks baik dari guru, petugas kesehatan dan orang tuaserta keaktifan remaja dalam mengikuti kegiatan posyandu remaja. Saran yang dapat diberikan oleh peneliti adalah untuk lebih meningkatkan lagi informasi tentang pendidikan seks kepada remaja guna merubah suatu sikap dalam menghadapi pubertas dan memberi kesempatan kepada peneliti lain yang tertarik pada masalah remaja untuk mengembangkan dan menggali lebih jauh faktor – faktor yang mempengaruhi sikap remaja tentang pendidikan seks.
EFEKTIVITAS MELATI AIR DALAM MENURUNKAN KADAR BOD, COD DAN TSS PADA AIR LIMBAH LAUNDRY
Authors: Noviana Linda 
Published: March 2021

Peningkatan industry pencucian pakaian dapat menimbulkan pencemaran mengakibatkan eutrofikasi.Sehingga perlu dilakukan alternative pengolahan dan pengaplikasian yang efektif untuk mengolah limbah ini, salah satunya dengan menggunakan fitoremediasi.Fitoremediasi adalah penggunaan tumbuhan untuk menghilangkan, menstabilkan atau menghancurkan bahan pencemar baik senyawa organic maupun anorganik. Penelitian ini bertujuan untuk mengetahui kemampuan tumbuhan Melati Air dalam menurunkan kadar BOD, COD dan TSS pada limbah laundry dengan variasi waktu kontak 7, 14 dan 21 dengan perbedaan banyaknya tumbuhan yaitu 2, 4, 6 dan 8 tanaman. Sedangkan efektivitas penyerapan pada tanaman Melati Air adalah pada hari ke 14.
Ultrasonographic assessment of lower uterine segment thickness and perinatal Outcomes in patients with a previous cesarean history
Authors: Kadıoğlu Nezaket , Güler Başak , Patakoğlu Ebru Aslan , Özkan Eda , Sert Umit Yasemin , Çelen Sevki 
Published: March 2021

Objective: The purpose of the study was to establish the validity of the abdominal evaluation of lower uterine segment (LUS) thickness in patients having a previous cesarean section (CS) in predicting uterine rupture, and to evaluate if there is any effect of the number of a previous surgeries on adverse maternal and perinatal outcomes.
Materials and methods: A prospective case-control study was carried out between December 2017 and June 2018 in Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital. 555 patients were classified into three groups; Group 1: patients having one previous CS, Group 2: patients having two previous CS, Group 3: patients having more than the two previous CS). Ultrasonographic measurements of the LUS, intraoperative findings and, adverse pregnancy outcomes were assessed.
Results: LUS thickness of group 2 was significantly less than the LUS thickness of the other groups (p=0.022). The feeling of pain was significantly more in the patients of group 2, when compared with the other groups (p=0.019). Pregnancy interval was the only parameter that had significant predictivity for adverse pregnancy outcomes for group 1(#CS=2) and group 3 (#CS≥4) (p=0.042, and p=0.021, respectively). In group 2 (#CS=3), age, the thickness of LUS, and thickness of subcutaneous adipose tissue were found to have significantly high predictivity for adverse pregnancy outcomes (p=0.012, p≤0.001, and p=0.007, respectively).
Conclusion: Measurement of LUS, in the patients who had previous CS, can be used for risk assessment and management. It is a non-invasive, reliable and, easily applicable method. Standardization of the measurement technique is a necessity.
IMPLEMENTASI KEGIATAN EKSTRAKURIKULER TILAWAH AL-QUR'AN DI MADRASARAH IBTIDAIYAH NEGERI 1 KOTA PALANGKA RAYA
Authors: Ali Muhammad Taghab , Winaryo Slamet , Sumarnie  
Published: March 2021

Abstrak: Penelitian ini bertujuan untuk mendeskripsikan tentang Implementasi Kegiatan Ekstrakurikuler Tilawah Al-Qur’an di Madrasah Ibtidaiyah Negeri 1 Kota Palangka Raya. Penelitian ini menggunakan pendekatan kualitatif dengan rancangan studi kasus. Sumber data dalam penelitian ini terdiri dari: Kepala Sekolah, Koordinator Ekstrakurkuler dan Pembina Ekstrakurikuler. Teknik pengumpulan data dengan metode observasi, wawancara dan studi dokumentasi. Analisis data menggunakan model interaktif data. Pengabsahan data menggunakan teknik triangulasi. Hasil penelitian ini menunjukan: (1) Perencanaan ekstrakurikuler Tilawah Al-Qur’an dilakukan kepala sekolah melibatkan banyak pihak untuk membahas terkait perencanaan ekstrakurikuler Tilawah Al-Qur’an untuk satu semester kedepan dengan pembentukan Tim, penentuan koordinator, pembina, sarana dan prasarana, waktu pelaksanaan, pendanaan, perekrutan peserta Tilawah; (2) Pengorganisasian ekstrakurikuler Tilawah Al-Qur’an dilakukan dengan membuat SK pengangkatan koordinator dan pembina oleh kepala sekolah; (3) Pelaksanaan ekstrakurikuler Tilawah Al-Qur’an dilakukan di musholla yang telah tersedia sarana yang lengkap dengan jadwal hari selasa dan kamis pada jam 13.30 sampai dengan jam 14.30 WIB, dan (4) Pengawasan ekstrakurikuler Tilawah Al-Qur’an dilakukan oleh kepala sekolah dan wakil kepala sekolah bidang kesiswaan.
Abstract: This study aims to describe the implementation of extracurricular activities of recitation of the Qur'an in Madrasah Ibtidaiyah Negeri 1 Palangka Raya City. This study used a qualitative approach with case study design. Sources of data in this study consisted of: the principal, the extracurricular coordinator and the extracurricular coach. Data collection techniques using observation, interview and documentation study methods. Data analysis using an interactive data model. The data validation used triangulation technique. The results of this study indicate: (1) The principal's planning for extracurricular recitation of the Qur'an involves many parties to discuss extracurricular planning for the recitation of the Qur'an for the next semester by forming a team, determining the coordinator, supervisor, facilities and infrastructure, implementation time, funding, recruitment of recitation participants; (2) Organizing extracurricular recitation of Al-Qur'an is done by making a decree for the appointment of a coordinator and supervisor by the school principal; (3) Implementation of extracurricular recitation of the Qur'an is carried out in a prayer room which has complete facilities with a schedule on Tuesday and Thursday from 13.30 to 14.30 WIB, and (4) Supervision of extracurricular recitation of the Al-Qur'an is carried out by the head school and vice principal of student affairs.
Tactile temporal offset cues reduce visual representational momentum
Authors: Merz Simon , Frings Christian , Spence Charles 
Published: March 2021

AbstractThe perception of dynamic objects is sometimes biased. For example, localizing a moving object after it has disappeared results in a perceptual shift in the direction of motion, a bias known as representational momentum. We investigated whether the temporal characteristics of an irrelevant, spatially uninformative vibrotactile stimulus bias the perceived location of a visual target. In two visuotactile experiments, participants judged the final location of a dynamic, visual target. Simultaneously, a continuous (starting with the onset of the visual target, Experiments 1 and 2) or brief (33-ms stimulation, Experiment 2) vibrotactile stimulus (at the palm of participant’s hands) was presented, and the offset disparity between the visual target and tactile stimulation was systematically varied. The results indicate a cross-modal influence of tactile stimulation on the perceived final location of the visual target. Closer inspection of the nature of this cross-modal influence, observed here for the first time, reveals that the vibrotactile stimulus was likely just taken as a temporal cue regarding the offset of the visual target, but no strong interaction and combined processing of the two stimuli occurred. The present results are related to similar cross-modal temporal illusions and current accounts of multisensory perception, integration, and cross-modal facilitation.
Mental representation of autobiographical memories along the sagittal mental timeline: Evidence from spatiotemporal interference
Authors: Teghil Alice , Marc Isabel Beatrice , Boccia Maddalena 
Published: March 2021

AbstractTime is usually conceived of in terms of space: many natural languages refer to time according to a back-to-front axis. Indeed, whereas the past is usually conceived to be “behind us”, the future is considered to be “in front of us.” Despite temporal coding is pivotal for the development of autonoetic consciousness, little is known about the organization of autobiographical memories along this axis. Here we developed a spatial compatibility task (SCT) to test the organization of autobiographical memories along the sagittal plane, using spatiotemporal interference. Twenty-one participants were asked to recall both episodic and semantic autobiographical memories (EAM and SAM, respectively) to be used in the SCT. Then, during the SCT, they were asked to decide whether each event occurred before or after the event presented right before, using a response code that could be compatible with the back-to-front axis (future in front) or not (future at back). We found that performance was significantly worse during the non-compatible condition, especially for EAM. The results are discussed in light of the evidence for spatiotemporal encoding of episodic autobiographical memories, taking into account possible mechanisms explaining compatibility effects.
Empirica: a virtual lab for high-throughput macro-level experiments
Authors: Almaatouq Abdullah , Becker Joshua , Houghton James P. , Paton Nicolas , Watts Duncan J. , Whiting Mark E. 
Published: March 2021

AbstractVirtual labs allow researchers to design high-throughput and macro-level experiments that are not feasible in traditional in-person physical lab settings. Despite the increasing popularity of online research, researchers still face many technical and logistical barriers when designing and deploying virtual lab experiments. While several platforms exist to facilitate the development of virtual lab experiments, they typically present researchers with a stark trade-off between usability and functionality. We introduce Empirica: a modular virtual lab that offers a solution to the usability–functionality trade-off by employing a “flexible defaults” design strategy. This strategy enables us to maintain complete “build anything” flexibility while offering a development platform that is accessible to novice programmers. Empirica’s architecture is designed to allow for parameterizable experimental designs, reusable protocols, and rapid development. These features will increase the accessibility of virtual lab experiments, remove barriers to innovation in experiment design, and enable rapid progress in the understanding of human behavior.
Efficiency mark postoperative pain management and normalization of adaptation status in patients with reproductive system oncopathology
Authors: Rozenko D. A. , Shikhlyarova A. I. , Popova N. N. , Verenikina E. V. , Menshenina A. P. , Ardzha A. Yu. , Shulga A. V. 
Published: March 2021

Purpose of the study. Studying possible management of postoperative pain and normalization of adaptation status in patients with reproductive system onychopathology using xenon- oxygen therapy.Patients and methods. The study included 97 patients receiving surgical treatment for reproductive cancer at National Medical Research Centre for Oncology in 2016–2020. All patients were divided into the main and control groups depending on the performed corrective therapy with xenon- oxygen mixture. Inclusion criteria were: established diagnosis — endometrial cancer, cervical cancer or ovarian cancer at the surgical stage of antitumor treatment, absence of decompensated concomitant pathology. In addition to general clinical tests, the intensity of symptoms in patients was assessed using a standardized Edmonton questionnaire, adaptation status and data of a numerical rating scale of pain were recorded, the severity of endogenous intoxication was measured using calculated lymphocytic, leukocyte, nuclear and leukocyte shift index. Stages of the study included functional assessment of the patient's condition before surgical treatment and on the 1st and 5th days of the postoperative period.Results. An analysis showed statistically significant differences between the groups: in the group of patients receiving xenon- oxygen therapy, 12.9% of patients complained of pain, while in the control group — 34.2%, on mild exertion 17.1% and 39.9%, respectively (p<0.05). The therapy with xenon- oxygen mixture demonstrated its high significance in the adaptive status regulation and regression of negative clinical manifestations in patients after oncogynecological surgeries.Conclusion. The effectiveness of the chosen therapy with xenon- oxygen mixture demonstrates the possibility of anesthesia and normalization of the adaptive status of oncogynecological patients who underwent surgical treatment for reproductive cancers.
Using the digital archive of pathological reports of stomach cancer as internal quality control of coding according to the ICD-O system
Authors: Kit O. I. , Fomenko Yu. A. , Karnaukhov N. S. , Lapteva T. O. , Voloshin M. V. , Vakulenko G. Yu. , Bosenko S. Zh-P. , Suhar I. A. , Eremin K. S. , Kaminskij G. V. , Kuznecova M. A. 
Published: March 2021

Purpose of the study. Demonstrate the possibilities of statistical analysis of the digital archive at pathological department (PD). To conduct internal quality control of the coding of malignant tumors according to the ICD-O-3 system of pathology reports using the example of gastric cancer (GC).Materials and methods. We retrospectively analyzed the digital archive of 368,157 pathology reports of the National Medical Research Centre for Oncology of the Ministry of Health of Russia from 2000 to 2019. For the study, 4,857 pathology reports of patients operated for gastric malignancies (ICD-X codes: C16.0 – C16.9) were selected for the period from 2000 to 2019.Results. The analysis of 368,157 protocols of the digital archive of PD revealed 4,614 malignant epithelial tumors of the stomach: tubular adenocarcinoma – 2,958, signet ring cell carcinoma – 791, undifferentiated cancer – 565, mucinous adenocarcinoma – 210, neuroendocrine neoplasia – 90. A significant increase in the ICD-O codes for "adenocarcinoma NOS" was found in 2018 and 2019. The pathology reports for these 2 years were reviewed by an independent pathologist and changes were made to the ICD-O codes according to the WHO classification digestive system tumors 2019. The adenocarcinoma NOS (8140/3) was replaced by the codes: tubular adenocarcinoma (ICD-O: 8211/3) – 41%, papillary adenocarcinoma (8260/3) – 9% and adenocarcinoma with mixed subtypes (8255/3) – 29%.Conclusion. The study, based on analysis of coding ICD-O stomach MN demonstrated the importance of digital archive at the PD, as a tool for rapid static analysis pathology reports and quality control of coding. The coding system can be the basis for large multicenter studies in oncology. Therefore, it is important to control the quality of coding of the pathology reports and to timely update the codes when new pathological classifications are released.
Сombined ships stability analysis at the stage of design study
Authors: Gulyaev Ilya A. Gulyaev , Ronnov Evgeniy P. 
Published: March 2021

. A method of stability analysis for combined ship (oil carrier/platform ship type) at the stage of design study is presented. It should be noted that not all of ship’s main seaworthiness and operational characteristics are the result of a simple addition of the characteristics of an oil carrier and a platform ship. Their mutual influence takes place, which should be taken into account when analysing the stability in the multivariant optimization problems of internal and external design of such ships. This leads to the requirement to adjust the known methods of stability analysis at the initial stages of ship design, which was the purpose of the present work and its originality.
Taking into account the multivariance of the task and the hull design type, the stability assessment will be carried out through the analysis of the metacentric height extreme value on the assumption that the requirements of Russian River Register for admissible heeling angle at static wind effect are met. In order to account for nonlinearity of static stability curve when inclining up to the angles of deck immersion into water and emergence of bilge, it is suggested to apply an approximate method of metacentric radius determination.
The proposed method of combined ship stability assessment is recommended to apply at the stage of justification and analysis of ship’s key elements as a limitation in the problems of mathematical modeling of optimization of such type of ships. The method allows to exclude from further consideration at the design study stage the possible options that do not meet the requirements of seaworthiness.
DİL EDİNİMİNDE ÖNE ÇIKAN KURAMLAR: ANALİTİK YAKLAŞIM
Authors: AKTAŞ Osman , YAQOOB Luay Hatem 
Published: March 2021

Dil, hayatın bütün alanları ile ilgili bilgi edinmenin ve bireyler arası iletişimin sağlanmasında temel görevlerden birini yerine getiren en önemli araçlardan biridir. Herhangi bir toplumun gelenek ve göreneklerini öğrenmeyi sağlayan yollardan biri de dildir. Bilgi, duygu ve düşünceleri şekillendiren ve filozofların hikmet olarak isimlendirdikleri bilgeliğe ulaştıran unsurların en önemlilerinden biri dildir. Dil olmaksızın insanların bilimsel faaliyetleri sürdürmesi mümkün değildir. Çünkü dil, önceki kuşaklardan aktarılan bilimsel mirası sonraki kuşaklara aktaran önemli araçtır. Ayrıca zaman, bilimsel ve kültürel gerçeklik, dil olgusuna duyulan gereksinimi zorunlu kılmaktadır. Bundan dolayı dil eğitimi ile ilgili ve dil ediniminin en etkili ve en iyi yollarına dair yapılan araştırmalar büyük bir önem kazanmaktadır.
Bu araştırma, dil edinimi ve dil öğretimi olgusuna ve bu iki olgu arasındaki farka değinmektedir. Ayrıca konusu dil edinimi olan en önemli kuramları, dil edinimi alanında araştırmaları bulunan dil felsefecilerinin bu konudaki görüşlerini de ele almaktadır.
Bu çalışma, en önemli dil edinimi kuramlarını bilimsel ve karşılaştırmalı bir şekilde sunmayı ve yorumlamayı amaçlamaktadır. Dil edinimi kuramları arasında yapılacak karşılaştırmaların dil öğretimi ve dil edinimi alanına katkı sunacak çıkarımlar olması amaçlanmaktadır.
PENGGUNAAN BAHAN AJAR ELEKTRONIK MULTIMEDIA BERBASIS BUDAYA LOKAL PADA TEMA DAERAH TEMPAT TINGGALKU UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR TINGKAT TINGGI SISWA SEKOLAH DASAR
Authors: Lawe Yosefina Uge , Noge Maria Desidaria , Wede Edelbertus , Itu Irmina Marince 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan berpikir tingkat tinggi pada tema daerah tempat tinggalku pada siswa dengan menggunakan bahan ajar elktronik multimedia berbasis budaya lokal. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) dengan menggunakan desain Kemmis dan Taggart. Subjek dalam penelitian ini adalah siswa kelas IV SDN Linajawa objek dalam penelitian ini adalah bahan ajar elektronik multimedia berbasis budaya lokal untuk meningktakan kemampuan berpikir tingkat tinggi belajar pada tema daerah tempat tinggalku. Metode pengumpulan data dalam penelitian ini adalah dengan menggunakan lembar observasi dan tes hasil belajar. Teknik analisis data dalam penelitian ini adalah deskripsi kualitatif dan deskripsi kuantitatif. Berdasarkan hasil penelitian yang dilaksanakan pada siklus I dan siklus II diperoleh nilai kemampuan berpikir tingkat tinggi siswa kelas IV SDN Linajawa menerapkan pembelajaran dengan menggunakan bahan ajar tematik multimedia berbasis budaya lokal Ngada pada tema Daerah Tempat Tinggalku sebagai berikut. Pada siklus I diperoleh rata-rata sebesar 52, dengan rata-rata presentase sebesar 52% berada pada rentangan 50-65 dengan kriteria rendah. Siklus II diperoleh nilai rata-rata sebesar 82,88, dengan rata-rata presentase sebesar 82,88%, berada pada rentangan 79-90 dengan kriteria tinggi. Pada penelitian ini telah terjadi peningkatan nilai kemapuan berpikir tingkat tinggi pada siswa kelas IV SDN Linajawa dari siklus I ke siklus II sebesar 30,88%. Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunaan bahan ajar tematik elektronik berbasis budaya lokal Ngada dapat meningkatkan nilai kemapuan berpikir tingkat tinggi pada siswa kelas IV SDN Linajawa, Kecamatan Golewa Barat Kabupaten Ngada.