bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics in the Spatiotemporal Variation and Periodic Evolution of Groundwater in the Xining Area of China, Eastern Qinghai–Tibet Plateau
Authors: Li Huanhuan , Zhan Runze , Lu Yudong , Zhou Bao , Wu Jing 
Published: April 2021

Abstract
Groundwater, an important source of water, has profound effects on global human survival and production. The spatiotemporal characteristics of groundwater and the periodic variation law of different time scales must be analyzed to grasp the dynamic situation of groundwater and provide scientific guidance for the rational utilization and management of groundwater resources. In this study, the temporal and spatial variability and periodicity of groundwater level were studied in the Xining region of the eastern Qinghai–Tibet Plateau China using traditional statistical method, geographic information system and Morlet wavelet analysis. Results show that the groundwater dynamics in the study area are mainly controlled by three factors, namely, the amount of river water infiltration, discharge from the groundwater, and artificial exploitation. The aforementioned factors can be divided into three dynamic types according to their combination relationship: hydrological, hydrological exploitation, and runoff-discharge types. The groundwater depth showed a trend of first increasing, then stabilizing, and finally decreasing from 1980 to 2020. The analysis in spatial variability demonstrated that the groundwater depth in different periods has a great spatial difference, with a moderate spatial variation intensity. Moreover, the spatial correlation of groundwater in the abundant season is lower than that in the dry season, which is mainly caused by the strengthening of artificial exploitation. The groundwater depth in the Xining region presents a pattern of deep in the south and east and shallow in the north and west by Kriging interpolation of spherical model in geographic information system. Meanwhile, the inter-annual groundwater has continued to decline since the chronic overexploitation between the 1960s and 2000s, with a maximum cumulative depth of 15 m. Then, the amount extraction had been further reduced, and rainfall had significantly increased in recent years. Accordingly, the cone of depression has undergone an evolutionary process from an expansion period to a stable period to a shrinking period. Furthermore, the annual groundwater level of most monitoring wells in study area has the same multi-year scale time variation characteristics with an evident regular periodic variation on the 9-14a and 17-25a time scales by using Morlet wavelet transform analysis. The temporal sequence of groundwater from 1980 to 2020 has the first and second main periods of 12a and 21a. In accordance with the two time-scales, the groundwater level will continue to rise in the short term in the future, which provides a scientific theoretical basis for the long-term sustainable development of groundwater resources and government decision-making.
Green Manure Effect on The Ability of Native and Inoculated Soil Bacteria to Mobilize Zinc for Wheat Uptake (Triticum Aestivum L.)
Authors: Costerousse Benjamin , Quattrini Joel , Grüter Roman , Frossard Emmanuel , Thonar Cécile 
Published: April 2021

Abstract
PurposeGreen manuring can increase the plant available fraction of zinc (Zn) in soil, making it a potential approach to increase wheat Zn concentrations and fight human Zn deficiency. We tested whether green manure increases the ability of both the native soil bacteria and inoculated Zn solubilizing bacteria (ZSB) to mobilize Zn.MethodsWheat was grown in a pot experiment with the following three factors (with or without); (i) clover addition; (ii) soil x-ray irradiation (i.e. elimination of the whole soil biota followed by re-inoculation with the native soil bacteria); and (iii) ZSB inoculation. The incorporation of clover in both the irradiated and the ZSB treatments allowed us to test green manure effects on the mobilization of Zn by indigenous soil bacteria as well as by inoculated strains.ResultsInoculation with ZSB did neither increase soil Zn availability nor wheat Zn uptake. The highest soil Zn availabilities were found when clover was incorporated, particularly in the irradiated soils (containing only soil bacteria). This was partly associated with the stimulation of bacterial activity during the decomposition of the incorporated green manure.ConclusionThe results support that the activity of soil bacteria is intimately involved in the mobilization of Zn following the incorporation of green manure.
Assessment of needle stick injuries among healthcare workers: a cross-sectional study from Kakiri military and SOS hospitals, Uganda
Authors: Basaza Robert K , Otieno Emmanuel D , Haddock Christopher K 
Published: April 2021

Abstract
Background: The Ugandan military medical services work together with the civilian public health system to deliver quality healthcare. This Partnership is the mainstay of health service delivery in Uganda. The burden of needle stick injuries (NSIs) is increasing in Uganda’s larger health industry; however, data on needle stick injury in military and public health facilities is lacking. No published data exist on comparative studies for a mix of facilities both military and civilian health settings. This study represents the first time this issue has been studied in a military or public health hospital in Uganda.Methods: A hospital-based, cross-sectional study was conducted in July 2018 to September 2019 in Kakiri Military and SOS Hospitals in Uganda using a structured questionnaire. Respondents were purposively selected based on the objectives of study, occupation status and department (N = 310). Results: The overall prevalence of NSIs among respondents was 27.2% and prevalence rates for the two facilities was nearly identical. The largest percentage of NSIs occurred during drawing venous blood samples (49.4%). Significant predictors of NSI were gender, occupational status, age, poor knowledge on prevention and post exposure of NSI, and less professional experience. Infection control practices were lacking in both selected health facilities. Conclusion: Over a quarter of HCWs in Uganda reported NSIs, which places them at significant health risk. Fostering the practice of universal precautions, best infection control practices and training of healthcare workers on bio-safety measures can reduce the prevalence of NSIs.Trial Registration: Not Applicable
Warm autoadsorption using ZZAP
Authors: Tsimba-Chitsva F.M. , Caballero A. , Svatora B. 
Published: April 2021

Abstract
The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion practices such as the issuing of “least incompatible” red blood cells (RBCs) without a complete antibody workup is potentially unsafe for patients. Several autoadsorption methods can be used to remove autoantibody reactivity. ZZAP treatment of autologous RBCs is an efficient way to prepare the cells for autoadsorption. Autoadsorbed serum or plasma can then be used to remove autoantibody reactivity and identify clinically significant alloantibodies.
Immunohematology

2018;34: 1–3.
Rouleaux and saline replacement
Authors: Waider K.L. 
Published: April 2021

Abstract
Rouleaux is a phenomenon that commonly occurs in patients who have an increased number of circulating protein macromolecules. It is a benign, in vitro reaction that appears microscopically as red blood cells (RBCs) line up against each other; many liken the RBC aggregation to “stacked coins.” This unexpected reactivity may cause confusion in direct agglutination testing such as reverse blood typing and crossmatching. Saline replacement is the established method to resolve rouleaux. True agglutination will remain when plasma is replaced with saline for resuspension of the RBC button. Rouleaux will no longer be seen when the plasma proteins are removed.
Immunohematology

2018;34:91–92.
Detecting polyagglutinable red blood cells
Authors: Melland C. , Hintz C. 
Published: April 2021

Abstract
Polyagglutination is a condition in which red blood cells (RBCs) are agglutinated by normal adult human sera but not by autologous or newborn sera. Polyagglutination is caused by changes in the RBC membrane that enable patient RBCs to agglutinate with normal human sera; this agglutination can interfere with blood bank testing. Depending on the cause, polyagglutination may or may not be the cause of RBC hemolysis. Lectins and human sera can be used to detect polyagglutinable RBCs. Identification of this phenomenon can be helpful in providing not only transfusion recommendation information for physicians but also information associated with pathogens (i.e., Streptococcus pneumoniae) and severity of illness. Testing with ABO group–compatible adult human sera can determine if a patient’s RBCs are polyagglutinable. Further testing with a variey of lectins may identify the kind of polyagglutination.
Immunohematology

2018;34:113–117.
Use of the prewarm method for detecting clinically significant alloantibodies in the presence of cold autoantibodies
Authors: Dupuis S. 
Published: April 2021

Abstract
The prewarm (PW) method is useful for detecting and identifying clinically significant antibodies that bind to red blood cells and complement at 37°C and for avoiding antibodies that bind at temperatures less than 37°C. Antibodies that bind at temperatures less than 37°C are often cold autoantibodies that may be present in the serum of healthy individuals and are usually not clinically significant. The PW method is useful when these cold autoantibodies have a wide thermal range and interfere with standard testing methods by reacting at the 37°C and antihuman globulin test phases. When using the PW method, it is important to identify underlying, potentially clinically significant alloantibodies during pretransfusion testing to ensure the most appropriate component will be selected for transfusion.
Immunohematology

2018;34:148–150.
Cold autoadsorption
Authors: Ekema E.M. 
Published: April 2021

Abstract
Cold-reactive autoantibodies can mask the presence of underlying clinically significant alloantibodies in a patient’s plasma or serum. These autoantibodies are problematic when performing laboratory procedures such as ABO typing, red blood cell (RBC) crossmatching, antibody detection testing, and antibody identification. To avert the masking of clinically significant alloantibodies in a patient’s plasma or serum, adsorption studies can be performed at 4°C using autologous RBCs if the patient has not been recently transfused.
Immunohematology

2018;34:158–160.
PENGARUH PENGGUNAAN TANAH MEDITERAN SEBAGAI BAHAN SUBSTITUSI SEMEN TERHADAP KUAT TEKAN DAN TARIK BETON
Authors: Nilawardani Sri Devi 
Published: April 2021

Title: The Effect of Using Mediteran Soil as Cement Substitution Materials in Compressive Strength and Tensile Strength of Concrete
Concrete is a composite material (mixture) of cement, fine aggregate, coarse aggregate, and water. The potential of limestone in Indonesia is very large, reaching 28.678 billion tons which is the main ingredient in the cement manufacture. In the long run it will be depleted because it is a non-renewable natural resources. So to reduce the use of limestone the utilization of Mediteran soil as a substitution for some cement in the manufacture of concrete is required. The initial idea is based on the chemical composition contained in the Mediteran soil almost identical to the cement, which is carbonate (CaO) and silica (SiO2). The purpose of this research is to reveal the influence of substitution of Mediteran soil by 20% and 40% in the compressive strength and tensile of the concrete at age 3, 7, 14, and 28 days with the number of test specimen each 3 pieces on each variation in 10cm x20cm cylinder with planning of concrete mixture refers to SK SNI method T-15-1900-03. The type of research used is quantitative with the experimental method of laboratory test and data analysis of comparative method and regression. The results show that compressive strength and tensile strength of concrete using Mediteran soil substitution comparable to the strength of normal concrete with dry treatment. In the composition of 20% Mediteran soils decreased by 51.35% or 7.9 MPa (compressive strength) and 30.60% or 0.93 MPa (tensile strength). While the composition of 40% Mediteran soil decreased by 43.78% or 9.13 MPa (compressive strength) and 2.24% or 1.31 MPa (tensile strength).
Mammary gland condition in premenopausal women with endometrial hyperplasia
Authors: Dobrokhotova Y. E. , Narimanova M. R. , Saprykina L. V. , Ilina I. Yu. , Mazo M. L. 
Published: April 2021

Introduction.Amidst a steady increase in hyperplastic processes in uterus and mammary glands, numerous studies have shown that women with dyshormonal pathology of mammary glands had a range of gynecological diseases: external or internal endometriosis, hyperplastic processes of the endometrium and myometrium, polyps, polycystic ovary syndrome (PCOS), etc.Objective.To assess the mammary gland condition in premenopausal women with endometrial hyperplasia during indole-3-car-binol (I3C) therapy.Materials and methods.A total of 42 premenopausal patients aged 45-52 years (48.54 ± 1.83) were enrolled in an open-label prospective study. All patients received I3C 400 mg a day for 12 months. The examination included clinical laboratory, ultrasound imaging and mammographic examination of the mammary glands, cytologic examination of a nipple discharge. The examinations were carried out at the baseline, 6 and 12 months after starting treatment. The study findings were evaluated using descriptive statistics. Differences were considered significant at p <0.05.Results and discussion. All patients were diagnosed as having mastalgia before starting treatment. Mammary gland ultrasound imaging showed that the frequency of BI-RADS 2 was 9.5 times higher than that of BI-RADS 1 (90.5% and 9.5%, respectively, p <0.05). Mammography revealed that the frequency of BI-RADS 2 was 9.26 times higher than that of BI-RADS 1 (88% and 9.5%, respectively, p <0.05). After 6-month therapy, 59.5% of patients reported the disappearance of pain syndrome, the number of patients with ONE1/16a-ONE1 deviations decreased by 22%, 7.1% of patients showed improvement of ultrasound picture in BI-RADS. After 12-month therapy, the number of patients with ONE1 / 16a-ONE1 deviations decreased by 92.86% compared with the figures before starting treatment, ultrasound imaging showed improvement in the BI-RADS picture in 19% of patients, mammography findings - in 28.5% of patients. I3C is an effective and safe method to treat benign breast diseases in premenopausal women.Conclusion. Indole-3-carbinol therapy can be assessed as the treatment having an influence on the general components of pathogenesis of endometrial hyperplasia and benign hyperplastic processes in mammary glands. It is advisable to consider the use of indole-3-carbinol combined with antioxidant resveratrol in clinical practice.
Alternatives to hormone therapy for management of climacteric syndrome
Authors: Dikke G. B. 
Published: April 2021

The “gold” standard of treatment for women with menopausal syndrome (MS) is hormonal therapy, which, however, may not be acceptable in all cases, which determines the need to choose other methods.Effective alternatives to the treatment of MS are tissue-selective modulators of estrogen receptors and phytoestrogens, which contribute to the reduction of both early (vegetative-vascular and psycho-emotional) and mid-term and late disorders (osteoporosis), in contrast to selective serotonin reuptake inhibitors and serotonin / norepinephrine, which affect only the vegetative-vascular and psychoemotional symptoms and bisforphonates, which prevent the loss of bone mineral density. Isoflavones of red clover at a dose of 40 mg when taken for 3 months lead to a reduction in hot flashes in 47-85% of patients, insomnia in 53%, anxiety and depression in 76-81%, and also has a positive effect on endocrine-metabolic disorders and bone mineral density with prolonged use. Their use has been shown to be safe for 3 years. Controlling stress through cognitive behavioral therapy (positive effects on psychological symptoms, stress and depression) and clinical hypnosis (reducing symptoms by 50%) may be helpful in relieving MS symptoms. Supplements with vitamins C, D, K and calcium can be recommended to maintain healthy bones, antioxidants (vitamins C and E) - to enhance the effects of pharmacotherapy. There is no evidence of benefits for vasomotor symptoms of yoga, breathing exercises, relaxation, herbal and homeopathic remedies, nutritional supplements.The information accumulated to date on the efficacy and safety of phytoestrogens (red clover extract) makes it possible to recommend them as an alternative to MHT for the treatment of disorders associated with involutive changes in the female reproductive system during the peri- and postmenopausal period.
Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development
Authors: Khushboo  , Kumar Abhishek , Sharma Bechan 
Published: April 2021

Background:Depression is the most common mental disorder. The symptoms of depression include loss of energy, changes in appetite, more or less sleep, anxiety, low concentration, uncertainty, restlessness, feelings of worthlessness, guilt, or despair, and thoughts of self-harm or suicide. In order to provide safe, efficient, and cost-effective medication, the plant-based principles in isolation or combination with traditional antidepressants are gaining increasing attention for depression therapy.Method:This study includes the information regarding the present review and its contents collected from published literature materials in different international journals. We have used different search engines such as PubMed, Medline, ResearchGate, Google Semantic Scholar, and Science Direct. For this purpose, the data obtained were properly organized and analyzed to include in this article.Results:Most of the phytomolecules isolated from the medicinal plants display antidepressant effects through the synaptic regulation of levels of neurotransmitters such as dopamine, serotonin, and noradrenaline in different parts of the brain. The mechanism of action of phytomolecules also involves negative regulation of the activities of monoamine oxidase (MAO) and acetylcholinesterase (AChE) and prevention of hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. In addition, the strong antioxidative and anti-inflammatory potential of these phytochemicals offer synergy to their antidepressant as well as antipsychosomatic functions.Conclusion:The application of phytochemicals has proved it to be a safe, cost-effective, and efficient therapeutic agent to treat patients suffering from mild to severe states of depression and other psychiatric disorders. The potential phytochemicals may be further optimized using in silico tools to develop better antidepressants and antipsychotic agents in the future.
The Association between Occlusal Features and Temporomandibular Disorders in Northern Jordan: A Cross-sectional Study
Authors: Alrashdan Mohammad S. , Shaweesh Ashraf , Khasawneh Abeer A. , Sannoh Mohamed H. 
Published: April 2021

Objective:
To evaluate the possible correlation between basic occlusal features and the outcomes of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I.

Materials and Methods:
A convenient sample of Northern Jordanians was used in the study. Participants were examined in accordance with DC/TMD protocol. Nine occlusal features represented the independent variables; overjet, overbite, midline deviation, pain-free opening, maximum assisted opening, maximum unassisted opening, lateral excursions and protrusion, in addition to the opening pattern (classified as straight, corrected deviation and uncorrected deviation). DC/TMD diagnostic outcomes and their associated features represented the dependent variables, namely, pain-related TMD, Intra-articular Disorders (IAD), Degenerative Joint Disease (DJD), joint sounds (clicking and crepitus), joint locking and headache attributed to TMD. Binary logistic regression, multinomial logistic regression and Chi-square tests were used for statistical analyses.

Results:
A total of 400 participants represented the study population (mean age = 32.3±12.4 years, males=48%, females=52%). 71 subjects (18%) were diagnosed with pain-related TMD, 52 (13%) with IAD, 6 (1.5%) with DJD and 38 (10%) with headache due to TMD. Gender had a significant correlation with pain-related TMD (p= 0.014, OR= 2.16). Maximum pain free opening had a significant inverse relationship with pain related TMD (p= 0.013, OR=0.94), while midline deviation and corrected deviation mouth opening pattern had a significant correlation with IAD (p= 0.04,0.02, OR= 1.30,2.74, respectively). Overbite, midline deviation and pain free opening were significantly associated with unilateral open/close clicking (p= 0.04,0.05,0.03, OR= 0.77, 1.31, 0.94, respectively).

Conclusion:
There is a minimal clinical significance of the correlation between dental occlusion and TMD.
Theories Informing eHealth Implementation: Systematic Review and Typology Classification
Authors: Heinsch Milena , Wyllie Jessica , Carlson Jamie , Wells Hannah , Tickner Campbell , Kay-Lambkin Frances 
Published: April 2021

Background
Theory-guided approaches to implementation science have informed translation efforts and the acceptance of eHealth (digital health) interventions in clinical care. However, there is scarce evidence on which theories are best suited to addressing the inherent complexity of eHealth implementation.

Objective
The objectives of this systematic review are to identify theories that inform and explain eHealth implementation and to classify these theories using the typology by Sovacool and Hess for theories of sociotechnical change.

Methods
An electronic search was conducted in the PsycINFO, MEDLINE, Embase, CINAHL, Scopus, Sociological Source Ultimate, Web of Science, ABI/INFORM, EBSCO, and ProQuest databases in June 2019. Studies were included if they were published between 2009 and June 2019; were written in English; reported on empirical research, regardless of study or publication type; reported on one or more theories in the context of eHealth implementation; and were published in a peer-reviewed journal. A total of 2 reviewers independently assessed the titles, abstracts, and full texts. Theories identified were classified using a typology for theories of sociotechnical change, which was considered a useful tool for ordering and analyzing the diverse theoretical approaches as a basis for future theory building.

Results
Of the 13,101 potentially relevant titles, 119 studies were included. The review identified 36 theories used to explain implementation approaches in eHealth. The most commonly used approaches were the Technology Acceptance Model (TAM) (n=33) and the Unified Theory of Acceptance and Use of Technology (UTAUT) (n=32). These theories were primarily concerned with individual and interpersonal elements of eHealth acceptance. Less common were theories that reflect the various disorderly social processes and structural dimensions of implementation, such as the normalization process theory (n=17) and the structuration theory (n=6).

Conclusions
Theories currently informing the implementation of eHealth interventions predominantly focus on predicting or explaining end-user acceptance. Theoretical perspectives that capture the dense and intricate relationships and structures required to enact sustainable change are less well represented in the eHealth literature. Given the growing acknowledgment of the inherent complexity of eHealth implementation, future research should develop and test models that recognize and reflect the multidimensional, dynamic, and relational nature of this process.