bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Thromboembolic Complications During Aneurysm Coiling: 2-Dimensional Operative Video
Authors: Domingo Ricardo A , Martinez Santos Jaime L , Ravindran Krishnan , Tawk Rabih G ,   We thank the ENRG Research Group, Arthur Adam , Bain Mark , Bendock Bernard , Binning Mandy Jo , Boulos Alan S , Crowley Webster , Fessler Richard , Grande Andrew , Guterman Lee , Hanel Ricardo , Hoit Daniel , Hopkins III L Nelson , Howington Jay , James Robert , Jankowitz Brian , Kan Peter , Khalessi Alex A , Kim Louis , Langer David , Lanzino Giuseppe , Levitt Michael , Levy Elad , Lopes Demetrius , Mack William , Mericle Robert , Mocco J , Ogilvy Chris , Pandey Aditya , Replogle Robert , Riina Howard , Ringer Andrew , Rodriguez Rafael , Saugaveau Eric , Schirmer Clemens , Siddiqui Adnan , Spiotta Alex , Sultan Ali , Tawk Rabih , Thomas Ajith , Turner Raymond , Veznedaroglu Erol , Welch Babu , White Jonathan 
Published: February 2021

Abstract
Thromboembolic complications during aneurysm coiling are rare, with higher rates noted in ruptured aneurysms as patients are not usually premedicated with dual antiplatelet therapy.
1,2
Management includes a series of escalating strategies, including medical therapy and intra-arterial thrombolysis.
3-6
Additional strategies include mechanical thrombectomy with suction aspiration and stent retrievers.
3
Intracranial stenting can be used as a last resource, especially in ruptured cases given the need for dual antiplatelets to prevent stent thrombosis.
2

We present the case of a 42-yr-old man with a ruptured left internal carotid artery aneurysm with associated intracranial and intraventricular hemorrhage. The patient was initially presented to an outside facility after he was found in bed unable to speak and with right hemiparesis. The patient consented for surgery and underwent external ventricular drain (EVD) placement for the treatment of obstructive hydrocephalus, followed by diagnostic cerebral angiogram and aneurysm coiling. After the deployment of the last coil, control angiogram showed a small filling defect at the interface between the aneurysm neck and the distal vessel. The patient received intravenous heparin for therapeutic ACT and aspirin load. After progressive enlargement of the thrombus, the patient received intra-arterial glycoprotein (GP) IIB/IIIA inhibitors with a microcatheter positioned proximal to the thrombus. As the thrombus mass continued to enlarge, mechanical thrombectomy with an aspiration catheter was performed twice. Follow-up angiogram 20 min after the second aspiration demonstrated near-complete resolution of the thrombus. The patient recovered from his right hemiparesis, and he was discharged to rehabilitation on POD #21.
The effects of brand equity and failure severity on remedy choice after a product recall
Authors: Raithel Sascha , Mafael Alexander , Hock Stefan J. 
Published: February 2021

PurposeThere is limited insight concerning a firm’s remedy choice after a product recall. This study aims to propose that failure severity and brand equity are key antecedents of remedy choice and provides empirical evidence for a non-linear relationship between pre-recall brand equity and the firm’s remedy offer that is moderated by severity.Design/methodology/approachThis study uses field data for 159 product recalls from 60 brands between January 2008 to February 2020 to estimate a probit model of the effects of failure severity, pre-recall brand equity and remedy choice.FindingsFirms with higher and lower pre-recall brand equity are less likely to offer full (vs partial) remedy compared to medium level pre-recall brand equity firms. Failure severity moderates this relationship positively, i.e. firms with low and high brand equity are more sensitive to failure severity and then select full instead of partial remedy.Research limitations/implicationsThis research reconciles contradictory arguments and research results about failure severity as an antecedent of remedy choice by introducing brand equity as another key variable. Future research could examine the psychological process of managerial decision-making through experiments.Practical implicationsThis study increases the awareness of the importance of remedy choice during product-harm crises and can help firms and regulators to better understand managerial decision-making mechanisms (and fallacies) during a product-harm crisis.Originality/valueThis study theoretically and empirically advances the limited literature on managerial decision-making in response to product recalls.
Reading literacy practices among retirees in Kenya: why and how public libraries matter to them
Authors: Mose Peter , Mose Everlyn 
Published: February 2021

PurposeThe purpose of this study was to establish reading practices among retirees and to what extent public libraries in Kenya are a source of information and knowledge to them.Design/methodology/approachThis was a qualitative study whose research questions were; what are retirees' reading practices? why do retirees engage in the reading practices they engage in? and to what extent do retirees use the public library for their reading practices? Purposive and snowballing were used as sampling techniques and interview was used for data collection. Data were analysed thematically.FindingsThe findings were that retirees' reading practices are fragmentary and erratic; retirees mainly engage in reading practices for spiritual reasons and for access of current information; and that retirees do not use the services of the public library for their reading activities.Research limitations/implicationsThe research sample is 16 subjects who might not represent features of the whole population. The findings are, however, an index to what the situation might be.Originality/valueThe findings are the result of actual qualitative research.
Active and healthy: a ten year group history designed to support relapse prevention for older people suffering with anxiety and/or depression
Authors: Cole John Charles 
Published: February 2021

Purpose
The purpose of this project was to determine if consumers of Older People’s Mental Health (OPMH) recovering from depression and/or anxiety would benefit, in terms of a reduction in symptomatology and an increase in overall quality of life, from a group program approach.

Design/methodology/approach
The Active & Healthy Group Program was developed drawing on evidenced-based psycho-education, psychotherapy, cognitive behavioural therapy and research on the effects of diet and activity on well-being. The program consists of six weekly sessions, each consisting of 50 min of psycho-education followed by physical and social activity of similar duration. Pre-and post-testing was undertaken using the Geriatric Depression Scale (GDS), Kessler 10 (K10) and European Health Interview Survey-Quality of Life-8 Item Index. In addition, participants completed a qualitative post-group survey focussing on their evaluation of the group, strengths and suggested improvements. The pre- and post-group measures were subjected to statistical analysis.

Findings
According to pre- and post-test measures, the majority of group participants showed significant reductions in depressive symptoms and psychological distress (GDS and K10). This aligned with an overall increase in measures of quality of life (WHO QOL 8).

Originality/value
This paper contributes to the emerging evidence that older people are often open to education and change, given a friendly non-confrontational environment where evidence is presented that challenges the negative stereotypes so often put forward about old age. Given the nature of the outcomes, Active & Healthy, perhaps, has the potential to impact on service transformation to incorporate group work of this type as a valuable adjunct to core service provision.
miRNAs as biomarkers for diagnosis of type 2 diabetes: A systematic review
Authors: González‐Sánchez Luis Edgar , Ortega‐Camarillo Clara , Contreras‐Ramos Alejandra , Barajas‐Nava Leticia Andrea 
Published: February 2021

AbstractBackgroundThis systematic review summarizes results of studies that evaluated the expression of microRNAs (miRs) in prediabetes or type 2 diabetes (T2D).MethodsThe information was obtained from PubMed, EMBL‐EBI, Wanfang, Trip Database, Lilacs, CINAHL, Human microRNA Disease Database (HMDD) v3.0, and Google. A qualitative synthesis of the results was performed and miRs frequency was graphically represented. From 1893 identified studies, only 55 fulfilled the inclusion criteria. These 55 studies analyzed miRs in T2D, and of them, 13 also described data of prediabetes.ResultsIn diabetics, 122 miRs were reported and 35 miRs for prediabetics. However, we identified that five miRs (‐122‐5p, 144‐3p, 210, 375, and ‐126b) were reported more often in diabetics and four (144‐3p, ‐192, 29a, and ‐30d) in prediabetics.ConclusionsCirculating miRs could be used as biomarkers of T2D. However, it is necessary to validate these microRNAs in prospective and multicenter studies with different population subgroups, considering age, gender, and risk factors.
Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator
Authors: Cadwell Cathryn R. , Bowman Sarah , Laszik Zoltan G. , Pekmezci Melike 
Published: February 2021

AbstractConversion of glass slides to digital images is necessary to capitalize on advances in computational pathology and could potentially transform our approach to primary diagnosis, research, and medical education. Most slide scanners have a limited maximum scannable area and utilize proprietary tissue detection algorithms to selectively scan regions that contain tissue, allowing for increased scanning speed and reduced file size compared to scanning the entire slide at high resolution. However, very small and faintly stained tissue fragments may not be recognized by these algorithms, leading to loss of fidelity in the digital image compared to the glass slides. Cavitron ultrasonic surgical aspirator (CUSA) is frequently used in brain tumor resections, resulting in highly fragmented specimens that are used for primary diagnosis. Here we evaluated the rate of loss of fidelity in 296 digital images from 40 CUSA‐resected brain tumors scanned using a Philips Ultra Fast Scanner. Overall, 54% of the slides (at least one from every case) showed loss of fidelity, with at least one tissue fragment not scanned at high resolution. The majority of the missed tissue fragments were small (<0.5 mm), but rare slides were missing fragments greater than 5 mm in greatest dimension. In addition, 19% of the slides with missing tissue showed no indication of loss of fidelity in the digital image itself; the missing tissue could only be appreciated upon review of the glass slides. These results highlight a potential liability in the use of digital images for primary diagnosis in CUSA‐resected brain tumor specimens.
Effects of temperature on survival, oviposition, and development rate of ‘greenhouse’ and ‘lupin’ strains of western flower thrips, Frankliniella occidentalis
Authors: Nielsen Mette‐Cecilie , Teulon David A.J. , Chapman R. Bruce , Butler Ruth C. , Drayton Gabby M. , Phillipsen Holger 
Published: February 2021

AbstractTwo strains of western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), are found in New Zealand. One strain was recorded in 1934 mainly from outdoor Lupinus arboreus Sims (lupin strain, a non‐pest); the other strain was first recorded in 1992 and is found mostly on greenhouse crops (greenhouse strain, a pest). To test whether this differential pest status may be explained by different temperature requirements, a comparative life‐history study was carried out assessing the effects of temperature on life‐history traits and thermal requirements for development. Thrips strains were verified using sequence alignment of the COI gene. Thrips from each strain were fed sucrose solution and pollen, and they were reared at 8, 10, 12, 17, 22, and 27 (± 2) °C, respectively (>80% r.h., L16:D8 photoperiod). Longevity decreased with increasing temperature for both strains; however, the greenhouse strain had a significantly longer lifespan at all temperatures. Overall, the greenhouse strain laid more eggs than the lupin strain at all temperatures, with the highest mean number laid at 22 °C for the lupin strain (36.3 total eggs/female) and at 17 °C for the greenhouse strain (63.2 total eggs/female). No significant difference between the two strains was found in regards to the effect of temperature on development rate, Tmin (minimum temperature required for development), and Do (degree days). We estimated that 227 degree‐days, above a threshold temperature of 7.7 °C, were required to complete development of the greenhouse strain. No life‐history data of either strain were obtained for 8 °C as eggs did not hatch or development had not completed. The lupin strain required 261 days above 5.7 °C for complete development. The results of the study did not support the hypothesis that the lupin strain’s outdoor non‐pest status was due to different temperature requirements compared with those of the greenhouse strain.
C2orf40 inhibits hepatocellular carcinoma through interaction with UBR5
Authors: Wu Yue , Xiang Qin , Lv Xiaoqin , Xiang Xia , Feng Zhihao , Tian Shaorong , Tang Jun , Xiang Tingxiu , Gong Jianping 
Published: February 2021

AbstractBackground and AimHepatocellular carcinoma (HCC) urgently needs a marker for early diagnosis and targeted treatment. C2orf40 has been identified as a tumor suppressor gene in many cancers. However, the precise role and regulatory mechanism by C2orf40 contribute to HCC remain elusive and merit exploration.MethodsReverse‐transcription PCR, quantitative real‐time PCR, and methylation‐specific PCR were used to detect expression and methylation of C2orf40 in HCC cell lines or tissues. The effects of C2orf40 in liver cancer cells were examined via colony formation, CCK8, transwell, and flow cytometric assays. The effect of C2orf40 on tumorigenesis in vivo was determined by xenografts and immunohistochemical analysis. Western blot, indirect immunofluorescence, Co‐IP, and cycloheximide (CHX) were used to further investigate the potential mechanism of C2orf40.ResultsThe down‐regulation of C2orf40 in hepatocellular cancer tissue samples is often related to the degree of methylation of its promoter CpG. The recovery of C2orf40 expression in HCC cell lines can induce G0/G1 phase arrest and apoptosis and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition (EMT) process, both in vivo and in vitro. In addition, C2orf40 can increase the expression of p21 through interaction with UBR5.ConclusionsLow expression levels of C2orf40 are related to the hypermethylation of its promoter. C2orf40 can inhibit HCC through UBR5‐dependent or p53‐independent mechanisms. C2orf40 may be a diagnostic biomarker and a potential therapeutic target in HCC.
Mavericks or misconstruction? A reply to Campbell and Allan
Authors: PALMER STEPHANIE , MARTIN STEVIE 
Published: February 2021

AbstractIn a jurisdiction without a codified constitution clearly demarcating the role of the courts, and given the centrality of the principle of parliamentary sovereignty to the United Kingdom's constitutional framework, criticism of the courts for overstepping the mark – particularly in politically contentious cases – is par for the course. In their 2019 article, Professors David Campbell and James Allan offer a criticism of the Supreme Court for what they describe as its surreptitious creation of judicial supremacy at the expense of parliamentary sovereignty. In support of their claim, the authors examine two particularly significant judgments: R (Miller and another) v. Secretary of State for Exiting the European Union and Re Northern Ireland Human Rights Commission's Application for Judicial Review. This reply discusses several problematic aspects of the authors’ critique of those judgments, demonstrating that, contrary to the authors’ claims, these cases do not provide evidence of a surreptitious attempt by the Supreme Court to expand its power.
Unsecured lending and the indigenous economy in Australia and South Africa
Authors: HUTCHISON ANDREW , ALLEN DOMINIQUE 
Published: February 2021

AbstractConsumer credit is closely regulated in both Australia and South Africa. Nevertheless, unsecured lending often results in financial hardship in low‐income communities. One aspect of this picture is the impact of the consumer debt burden on the Indigenous economy, which is disproportionately affected by poverty in both countries. Here we juxtapose the comparative regulatory regimes and then contextualize the law using an inter‐disciplinary account of each Indigenous economy. We find through this law‐in‐context comparison that neither Australia nor South Africa has fully resolved the problem of Indigenous financial hardship. This mutual failure is confirmed by the recent Kobelt decision of the High Court of Australia and the drastic measures enacted in the South African National Credit Amendment Act 2019. One positive lesson that South Africa provides is that accommodating the Indigenous economy in financial regulation can promote and empower that sector.
An Integrated Multi-Domain Analysis Environment for High Consequence Systems
Authors: Davis James , Scott Jason , Sztipanovits Janos , Karsai Gabor , Martinez Marcus 
Published: February 2021

Abstract
Modeling and analysis of high consequence, high assurance systems requires special modeling considerations. System safety and reliability information must be captured in the models. Previously, high consequence systems were modeled using separate, disjoint models for safety, reliability, and security. The MultiGraph Architecture facilitates the implementation of a model-integrated system for modeling and analysis of high assurance systems. Among the tools used for analyzing safety and reliability are a behavioral simulator and an automatic fault tree generation and analysis tool. Symbolic model checking techniques are used to efficiently investigate the system models. A method for converting finite state machine models to ordered binary decision diagrams allows the application of symbolic model checking routines to the system models. This integrated approach to modeling and analysis of high consequence systems ensures consistency between the models and the different analysis tools.
Retrofitting Industrial Manipulators for Study of Open Architecture Integration of Mechatronic Systems
Authors: Pannu Jat , Hu Xudong , Cheng Harry H. 
Published: February 2021

Abstract
We have developed a plug-and-play open architecture CH language environment for integration of mechatronic systems for network-based agile manufacturing (Cheng, 1993). For experimental verification of this language environment in real-time applications, the original controllers of two popular industrial robot manipulators Puma 560 and IBM 7575 have been completely retrofitted and integrated with a conveyer system to form a robot workcell. This robot workcell, bypassing their original controllers, can be programmed to run under the CH language environment. Details about retrofitting these two industrial manipulators with new servo control boards, A/D boards, and I/O boards running the CH language environment under a commercial real-time operating system will be described. The CH language environment is designed for open architecture integration of mechatronic systems. The user application program written in CH is computer platform independent, mechatronic device independent, and mechatronic system independent. A sample CH application program for simulated assembly operations of this robot workcell will be presented to demonstrate the underlying principles of open architecture integration of mechatronic systems under the programming paradigm of the CH language environment.
A Temporal Process Specification Language for Virtual Manufacturing Engineering
Authors: Lee David E. , Hahn H. Thomas 
Published: February 2021

Abstract
A process specification language is being developed for virtual manufacturing that provides a structured portable definition of a given manufacturing process as well as the ability to specify the temporal relationships between individual operation steps that compose a process. Based on the concepts embodied in markup languages such as HTML, SGML and XML, a portable process definition structure is defined. This structure provides a template from which virtual process specifications can be created. Subsequently, these structures can be exchanged between development environments for virtual process engineering and the actualized manufacturing facilities where processes are implemented. In addition, dependencies in time between the operation steps of a process such as common start times and operation serialization can be represented to allow for a complete specification of temporal behavior of a given manufacturing process. By providing this explicit mechanism for representing temporal constraints, a virtual manufacturing process can be viewed and utilized both in a localized application on a single virtual factory floor as well as distributed across multiple, interlinked virtual environments.
Features and Constraints in Architectural Design
Authors: De Vries Bauke , Jessurun Joran 
Published: February 2021

Abstract
The concepts of the experimental design system that are discussed are feature modeling and geometrical constraints. The main technique for creating the user environment is Virtual Reality. Feature modeling forms the basis for managing the design data. To start with, data storage is implemented in a Relational Data Base Management System. Along with this a (traditional) interface is developed for managing the data. Data management consists of feature type creation and feature type instancing. Features are used to define building elements, their relationships and additional constraints. Apart from the design data, geometrical data are stored. The system contains a library of parameterized geometrical objects which format is in coherence with the geometrical modeling environment (VR). Possible design solutions can be limited using geometrical constraints. Specifying connection types between building elements result in a set of solutions for the position of the bounding boxes of the building elements in space.
An Architecture for VR-Based Virtual Prototyping of Human-Operated Systems
Authors: Jayaram Sankar , Angster Scott R. , Gowda Sanjay , Jayaram Uma , Kreitzer Robert R. 
Published: February 2021

Abstract
Virtual prototyping is a relatively new field which is significantly changing the product development process. In many applications, virtual prototyping relies on virtual reality tools for analysis of designs. This paper presents an architecture for a virtual prototyping system which was created for the analysis of automotive interiors. This flexible and open architecture allows the integration of various virtual reality software and hardware tools with conventional state-of-the-art CAD/CAM tools to provide an integrated virtual prototyping environment. This architecture supports the automatic transfer of data from and to parametric CAD systems, human modeling for ergonomic evaluations (first person and third person perspectives), design modifications in the virtual environment, distributed evaluations of virtual prototypes, reverse transfer of design modifications to the CAD system, and preservation of design intent and assembly intent during modifications in the virtual environment.