bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial Function is Attenuated Following Total Sleep Deprivation in Healthy Young Adults
Authors: Holmer Brady J , Lapierre Stephanie , Alviar Carlos L , Lim Jisok , Sakarya Yasemin , New William , Eagle Michael , Schwartz Cody , Bhattal Gurjaspreet , Maharrey Phillip , Handberg Eileen M , Christou Demetra D 
Published: June 2021

Insufficient sleep has been linked to an increased risk for cardiovascular disease, but the underlying mechanisms have not been fully elucidated. Endothelial function, an independent predictor of future cardiovascular events and mortality, may be detrimentally affected by sleep deprivation but this has not been tested.PurposeWe investigated the influence of total sleep deprivation (TSD) on endothelial function in healthy young men.MethodsTwelve men free of sleep disorders, 18 to 27 years of age (22 ± 1 years; mean ± SEM), participated in this study. Endothelial function was assessed using brachial artery flow‐mediated dilation (FMD) via ultrasonography in response to reactive hyperemia following 5‐min forearm occlusion. FMD was measured at the same time in the morning following a night of: 1) regular sleep (CON) and 2) TSD. Subjects completed TSD under supervision while resting quietly and after abstaining ≥ 20 hrs from caffeine.ResultsThe duration of sleep deprivation ranged from 24.8 to 28.5 hrs (mean: 26.3 ± 1.3 hrs). TSD resulted in a ~42% attenuation in FMD (6.22 ± 1.10 vs. 3.62 ± 0.46 %; P = 0.016; CON vs. TSD). However, brachial artery diameter (4.43 ± 0.11 vs. 4.41 ± 0.11 mm; P = 0.4) and systolic and diastolic blood pressure (117 ± 2 vs. 117 ± 3 mmHg; P = 0.8 and 60 ± 1 vs. 64 ± 3 mmHg; P = 0.1, respectively) remained unchanged.ConclusionsBrachial artery endothelial function is attenuated following TSD in healthy young men. Strategies to mitigate the detrimental effects of sleep deprivation on endothelial function may be important for individuals who routinely undergo extended periods of sleep deprivation.Support or Funding InformationThis work was supported by the Gatorade Trust through funds distributed by the University of Florida, Department of Medicine.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Hispidulin attenuates atopic dermatitis‐like skin inflammation features in mice
Authors: Kang Jinjoo , Kim Sang‐Hyun 
Published: June 2021

BackgroundHispidulin (Scutellarein 6‐methyl ether or dinatin, HPD) is a flavone derivative found in plant exhibiting anti‐oxidant, anti‐inflammatory, anti‐mutagenic, and anti‐epileptic properties. This work explored the anti‐inflammatory activity of HPD focusing on the skin.ObjectiveThis study demonstrated the beneficial effects of hispidulin in atopic dermatitis (AD)‐like skin inflammation and underlying mechanisms of action.MethodsFor AD‐like skin inflammation, female BALB/c mice were challenged with 2, 4‐dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) for 4 weeks. HPD was orally administered (0.1, 1 or 10 mg/kg) for 5 consecutive days during 3 weeks. For in vitro study, keratinocytes (HaCaT) were pre‐treated with HPD (0.1, 1 or 10 μM) and then stimulated with tumor necrosis factor (TNF)‐α and interferon (IFN)‐γ.ResultsIn mouse model, oral administration of HPD reduced the redness, ear thickness, keratinization, infiltration of cells (tissue eosinophils and mast cells), and immunoglobulin (IgE, DFE‐specific IgE and IgG2a) levels in a dose‐dependent manner compared to AD‐like skin inflammation. In HaCaT, pre‐treatment of HPD significantly suppressed the expression of TNF‐α/IFN‐γ‐induced cytokines such as interleukin (IL)‐1β, IL‐6, IL‐8 and chemokine C‐C motif ligand 17, 22 in a concentration dependent manner. Furthermore, HPD inhibited the activation of signal transducer and activator of transcription 1 and nuclear translocation of nuclear factor‐κB.ConclusionBased on the anti‐inflammatory activities of HPD on AD‐like skin inflammation, we propose that HPD would be a helpful candidate for AD treatment.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Neuro‐Physio Quanta Coherence‐Congruence Energy Regulation using Meditation for Exploring Etiology of Chronic Pain
Authors: Einstein George P , Rahman Michael S , Konyk Carla M , Tulp Orien L 
Published: June 2021

Evidence in the last few decades have supported claim that meditation can reduce stress and promote health; the effects of which are on physical and mental health, and cognitive performance. There is more evidence about the specific parts of the brain involved in producing these positive influences. The neuronal pathways are not fully understood; the model of chronic pain however may provide better evidence also indicating that mindfulness meditation has both immediate and long‐term effects on cortical structures and activity involved in attention, emotional responding and pain. This is an important topic as chronic pain is so pervasive, and the available treatments do not provide adequate relief for most patients. Neuro‐endocrine influences such as in cortisol homeostasis is important for cognitive and affective functions that depend on cortisol‐sensitive brain regions including the hippocampus and prefrontal cortex. A review of these relationships is evidence of the systems‐based nature of the organism and the integrated nature of the biology involved. The Orien L. Tulp/G.P. Einstein/Michael S. Rahman model of Neuro‐Physio‐Quanta, Coherence‐Congruence, is a dynamic model and framework used to understand the mathematical and quanta relationships within the biochemical and biophysical aspects of the human organism it allows the understanding and prediction of non‐invasive neuromodulatory therapeutics like meditation. This study will also explore case studies in literature and clinical practice in support of the G. P Einstein model.Support or Funding InformationInstitutional Resources of USAT, UHH, and EMIThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Novel Sigma Receptor Ligand Enhances Memory and Mitigates Microglia Proliferation
Authors: Bhandari Suyesha , Farr Susan , Silwal Ashok , Crider Albert , House Austin , Umbaugh David , Sandoval Karin , Witt Ken 
Published: June 2021

Sigma receptor 1 (Sig1R) and 2 (Sig2R) are expressed in central nervous system, in neurons and microglia. Modulation of these receptors has been identified for the treatment of inflammatory and neurodegenerative disorders, including Alzheimer's disease (AD). This research evaluated the impact of BBZI, a novel pan‐selective Sig1R‐Sig2R ligand in mouse models of Alzheimer's disease and microglia activation.BBZI has high affinity Sig1R‐Sig2R (Sig1R: Ki=0.8nM; Sig2R: Ki=2.5nM), with 100‐fold selectivity over a panel of 30 other receptors. Twelve‐month old Senescence Accelerated Mouse Prone‐8 (SAMP8) and 3xTg AD mice were treated with BBZI (i.c.v.) across a dosing range (0, 0.001, 0.01, 0.1, 1.0μg), and assessed for memory response via T‐maze. BBZI was also evaluated in BV2 microglia cells concurrent with inflammatory activation via lipopolysaccharide (LPS). After plating for 24hrs, cells were treated for 24hrs with BBZI (0, 10, 100, 1000nM) against LPS (0, 10, 100ng/mL). Alamar Blue (cellular proliferation) and nitrite (surrogate of nitric oxide) output in media.BBZI significantly enhanced memory in SAMP8 mice at both 0.001μg and 0.01μg doses (p<0.01), and in 3xTg mice at 0.01μg dose (p<0.05), compared to vehicle controls. The mean percent reduction of alamar blue decreased with increasing concentrations of BBZI (p<0.05). The mean percent reduction of alamar blue was significantly lower for 1000nM BBZI compared to 0nM BBZI (p<0.05). No significant difference in nitrite level was observed with increasing concentrations of BBZI (p=0.65).These results identify pan‐selective Sig1R‐Sig2R ligand capacity to enhance memory in two age mouse models of AD, with further capacity to impact of microglial proliferation. Such a pan‐selective ligand shows viability for treatment of cognitive and neurodegenerative conditions.Support or Funding InformationThis work was supported by the School of Pharmacy, Southern Illinois University Edwardsville.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Plasma beta‐hydroxybutyrate and glucose after ingestion of a high fat meal in patients on ketogenic therapy for seizures
Authors: Jones Lauren L. , Borum Peggy R. 
Published: June 2021

Ketogenic therapy is a treatment for intractable epilepsy involving a high fat, adequate protein, and low carbohydrate diet. A prospective study was conducted to examine serum beta‐hydroxybutyrate (BHB) and glucose (Glu) response at fasting, 30 min, 1 hr, and 2 hr after the ingestion of a ketogenic meal. Patients were stratified by age and route of feeding and comparisons were made for BHB/Glu and percent change from fasting. Data were available for 23 patients with mean age of 10.2±5 years and time on diet of 51.4±38 months. Mean percent changes at 30 min, 1 hr, and 2 hr for both BHB and Glu were less than 10%. Regression analyses were performed for BHB/Glu and percent changes and ratio, Cal/kg/day, fat, carbohydrate, and protein % of calories, fat and carbohydrate in g/kg/day and all correlations (r) were found to be less than 0.5 and r2 less than 0.3. Time on diet correlated to percent change of BHB at 30 min (r=0.5, r2=0.3, p=0.01). Fasting BHB/Glu was negatively correlated with age (r= ‐0.5, r2=0.2, p=0.03). Overall, BHB and Glu levels are maintained relatively constant. Stabilization of energy metabolism may be a factor in the mechanism of action against seizures.Effect of time after meal and age on BHB/Glu*p<0.05, #p=0.09 comparing <10yr and >10yrGrant Funding SourceNIH ‐ General Clinical Research Center
Red Blood Cell Flux in Isolated Capillary Bifurcations
Authors: Fraser Graham Mathew , Dias Gemma Marie , Goldman Daniel , Ellis Christopher 
Published: June 2021

Capillary red blood cell (RBC) flux is the most important determinant of oxygen delivery to tissue. Simultaneous experimental measurement of flow throughout a microvascular network is impractical and necessitates predicting flow using computer simulations. Our existing model uses an empirically derived bifurcation rule (Pries et al., 1989) to determine RBC distribution between daughter branches. Our objective is to validate the existing model of microvascular blood flow on capillary networks versus in vivo measurements. Capillary networks in rat skeletal muscle were recorded and 4 capillary bifurcations were randomly selected for analysis (diameter 5.9±0.27 ?m, segment length 107.7±28.8 ?m). Custom vascular mapping software was used to reconstruct the real geometry of each bifurcation. Each capillary was analyzed to measure RBC velocity, tube hematocrit and RBC flux. The error in measured RBC flux in the parent compared to the sum of daughters was 1.9±8.3%. Discrete fluctuations of cell distribution over time were seen to have a significant impact on measured flux fraction (FF). Measured RBC FF in the higher flow daughters were 9±6.3% lower than the bifurcation rule predicted at equivalent flow rates. The stochastic nature of the bifurcation rule makes precise predictions of RBC distribution difficult where alternating cells paths can drastically impact measured FF.Supported by CIHR grant to DG and CGE.
Maternity Nursing Stops Too Soon
Authors: Todd Betsy 
Published: June 2021

Editor's note: From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over more than a century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but also reveal prevailing societal attitudes about women, health care, and human rights. Today's nursing school curricula rarely include nursing's history, but it's a history worth knowing. To this end, From the AJN Archives highlights articles selected to fit today's topics and times.
In this article from October 1975, Reva Rubin provides a fascinating historical overview of maternity nursing. She recounts the social and medical transformation of maternity care in the 20th century, emphasizing the nearly nonexistent support for pregnant, laboring, and postpartum women during much of that time.
Rubin ends her article with a passionate plea to nurses for attention to “our big failure . . . the postpartum period.” She hints at the causes of what we now know to be postpartum depression, calling the postpartum period “unbelievably cruel,” and noting that “tissue recovery is fairly simple. Recovery of the whole person, however, is much more complex and requires much more skilled nursing.”
In this issue, Barbara Marie Alba carries on the work of Rubin and other maternity nursing pioneers, providing a detailed overview of this subject in “Postpartum Depression: A Nurse's Guide.”—Betsy Todd, MPH, RN
Eliminating Hospital-Acquired Pressure Injuries Caused by Graduated Compression Stockings
Authors: Siby Tessy , Smith Uniqua , Shajimon Alice 
Published: June 2021

ABSTRACT

Purpose:
The purpose of this evidence-based practice project was to reduce the incidence of pressure injuries (PIs) from the use of graduated compression stockings in patients on a gastrointestinal (GI) sarcoma surgery unit. Before this project, the standard of care for preventing deep vein thrombosis (DVT) included the use of graduated compression stockings, anticoagulation therapy, and intermittent pneumatic compression devices. We sought to examine the impact on PI and DVT risk of using only anticoagulation therapy and intermittent pneumatic compression devices.

Methods:
The pilot phase of the project began in June 2017 when nurses on the GI sarcoma surgery unit initiated a practice change in which graduated compression stockings were removed during the 7 AM shift change and put back on the patient before bedtime. Data on the incidence of DVTs and PIs were already being collected in our institution's electronic health record and safety intelligence reporting system. The project team monitored the incidence of PIs and DVTs throughout the project. After the pilot project concluded in August 2017, the GI sarcoma surgery unit staff continued the practice of taking off graduated compression stockings during the day, until on June 2018 the use of graduated compression stockings was formally discontinued for all surgical patients, both during the day and night.

Results:
Data collected during the pilot phase revealed that no PIs or DVTs occurred among the 497 study patients on the GI sarcoma surgery unit. From June to October 2017, the unit cared for a total of 856 patients and PI and DVT rates remained at zero. From the start of the pilot project in June 2017 to October 2018 (five months after the discontinuation of graduated compression stockings on all surgical units) the unit cared for 3,141 patients—an average of 174 patients per month—and had a zero rate of PIs and DVTs.

Conclusions:
We found that the use of graduated compression stockings confers more risks than benefits for patients. Our findings prompted the discontinuation of graduated compression stockings use in postoperative patients throughout our institution. In the 17 months after the pilot project was initiated, no PIs occurred among patients in the GI sarcoma surgery unit, which also maintained a zero rate of DVTs.
Examining the Influence of Academic Nurse Educator Doctoral Degree Preparation on National League for Nursing Core Competency Skill Acquisition
Authors: Sebach Aaron M. 
Published: June 2021

Abstract

AIM
The purpose of the study was to examine the influence of academic nurse educator doctoral degree preparation on National League for Nursing (NLN) core competency skill acquisition.

BACKGROUND
Doctor of nursing practice (DNP) and doctor of philosophy (PhD) graduates frequently seek faculty positions, yet neither degree exclusively prepares graduates for careers in academia.

METHOD
A descriptive, correlational design was utilized to examine the influence of doctoral degree preparation on NLN core competency skill acquisition. A randomized, nationwide sample (N = 160) of full-time nurse educators teaching in American Association of Colleges of Nursing member schools across the United States completed the Nurse Educator Skill Acquisition Assessment.

RESULTS
PhD-prepared educators reported higher NLN core competency skill acquisition scores than DNP-prepared nurse educators. There were statistically significant differences in overall skill acquisition scores between DNP- and PhD-prepared nurse educators and for the “use assessment and evaluation” and “engage in scholarship” domains.

CONCLUSION
These findings provide opportunities for NLN core competency skill acquisition among DNP- and PhD-prepared faculty.
How Nursing Faculty Experience the Effects of Workplace Incivility
Authors: Sherrod Jayme Trocino , Lewallen Lynne Porter 
Published: June 2021

Abstract

AIM
The purpose of this study was to describe nursing faculty experiences with workplace incivility and the effect it has on their health. This article reports results of the qualitative portion of a larger study.

BACKGROUND
Nursing faculty have reported the physical and psychological impact of incivility on their lives. The negative effects that workplace incivility, specifically, has on nursing faculty require ongoing research and attention.

METHOD
Using an electronic survey, 249 nursing faculty from one Southeastern US state responded to two open-ended questions about workplace incivility and its effects. Data were analyzed using qualitative content analysis.

RESULTS
Four categories related to experiences with workplace incivility emerged: the experience; personal and professional impact; a reciprocal, organizational culture problem; and survival.

CONCLUSION
Nursing faculty experiences with workplace incivility constitute an organizational culture problem with both personal and professional implications.
Exploring the accuracy and precision of BP measurements
Authors: Herrera Fatima Claire , Siaron Kathrina B. , Stutzman Sonja E. , Wilson Jennifer , Olson DaiWai 
Published: June 2021

Abstract:
Accurate and precise BP measurements are crucial to clinical decision-making and interventions as healthcare professionals aim to prevent complications from hypertension, yet the literature provides no gold standard for measuring BP. This article discusses the additional research necessary to develop best practices and improve patient outcomes.
International networking guidelines for nurses
Authors: Gaisser D'Arcy J. , David Tamala , Rath Logan , Clancy Gráinne , Lawrence Constance , Munoz-Rojas Derby , Jones Uletha , Smalls Jennifer 
Published: June 2021

Abstract:
Basic guidelines are necessary for international networking in nursing. This article outlines the benefits of and strategies for networking, highlights the social and behavioral considerations of social networking, and presents potential guidelines for further discourse.
Role of tissue-resident memory T cells in the pathophysiology of allergic contact dermatitis
Authors: Lefevre Marine-Alexia , Vocanson Marc , Nosbaum Audrey 
Published: June 2021

Purpose of review
We bring updated knowledge on tissue-resident memory T cells (TRM), underlining their major role in the recurrence and the severity of allergic contact dermatitis (ACD).

Recent findings
ACD is a frequently encountered skin disease. It is defined as a delayed-type hypersensitivity reaction initiated by the recruitment of antigen-specific T cells into the skin of sensitized patients. ACD lesions tend to develop on already-exposed areas and worsen over time. That clinical observation has raised questions on the contribution of TRM to ACD recurrence and severity. TRM are memory T cells that persist in peripheral tissues, such as the skin, without recirculating through the blood. These cells provide effective immune memory against pathogens, but they may also participate in the development or exacerbation of numerous inflammatory diseases, including skin allergies. Recent works have demonstrated a major role for TRM in ACD pathophysiology.

Summary
In ACD, TRM accumulate preferentially at the allergen contact site during the sensitization phase. Thereafter, these cells cause a rapid and intense response to any new allergen exposure. They also play a key role in flare-ups of ACD and the chronicity and severity of the disease. These aspects suggest that TRM may have an interest as therapeutic targets.
A Cosmetic Surgical Approach Effectively Reconstructed Facial Nerve Paralysis
Authors: Nomoto Shunichi , Umezawa Hiroki , Ogawa Rei 
Published: June 2021

Summary:
In general, facial nerve palsy is treated by reconstructive surgeons, and the role of cosmetic surgeons is largely seen as secondary. The present report describes a case of refractory facial nerve palsy that arose after malignant parotid-tumor resection and high-dose radiotherapy, and that we reconstructed with a combination of cosmetic and reconstructive procedures. The procedures consisted of facelift techniques (lateral SMASectomy, creation of a nasolabial fold with three suture loops anchored at the temporal fascia, and frontal lift), a new wrinkle-removing technique wherein the frontal-muscle function was disrupted, and excision of surplus skin to rejuvenate the face. The outcomes were good, including at 1 year after surgery, and the 71-year-old patient expressed considerable satisfaction. The frontalis muscle resection effectively removed the wrinkles, helped balance the left and right sides, and permitted anti-aging surgery. This procedure has permanent effects, unlike other methods (eg, botulinum-toxin injections) that serve to weaken facial muscle function. It is notable that despite the high-dose radiotherapy the patient had received and the resulting extensive subcutaneous-tissue adhesion, our surgical protocol was relatively easy to perform as well as highly effective. Thus, even static reconstruction can give great hope and satisfaction to patients with facial nerve palsy.