bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leiomyoadenomatoid tumor of uterus: two case reports with literature review
Authors: Adorno Flora Ávila , Coelho Karina Munhoz de Paula Alves , Bublitz Giuliano Stefanello , Stall Jaqueline , de França Paulo Henrique Condeixa 
Published: February 2021

Abstract
Background
Adenomatoid tumors (AT) are benign neoplasms of mesothelial origin that occur more frequently in the genital tracts. In uterus, AT are usually located in the subserosa of the cornual myometrium. Microscopically, it is characterized by interanastomosing pseudoglands or pseudovascular spaces and striking smooth-muscle hypertrophy is often present. In some cases, the prominence of smooth muscle component simulates a leiomyoma and the lesion is denoted as a leiomyoadenomatoid tumor. The microscopic appearance of the adenomatoid component (AC) may mimic a malignant tumor due to irregular pseudoinfiltration with tubular formations. Just 16 cases with this morphological presentation were found in the literature review.

Case presentations
The first case, a 38-year-old female, showed lower abdominal pain, menorrhagia, postcoital bleeding and previous history of uterin leiomyoma. The second case, a 26-year-old female, had clinical complaint of metrorrhagia and received diagnostic hypothesis of leiomyoma after ultrasound image. Both underwent myomectomy. Microscopically, the uterine masses showed intersecting smooth muscle bundles and gland like areas lined by cuboidal epithelioid cells that stained positive for WT1, D2–40 and calretinin in immunohistochemical analysis.

Conclusions
The cases were diagnosed as leiomyoadenomatoid tumor of the uterus. This is a benign and rare entity that may mimic malignant tumors due to the pseudo infiltrative appereance of the adenomatoid component, possibly leading to misdiagnosis.
Portable sterilizer with microbe content detection device
Authors: Banerjee Sreerup , Raghunathan Shriram , Banerjee Saubhik , Bandyopadhyay Boudhayan 
Published: February 2021

Abstract
Background
Infectious diseases, such as the latest COVID pandemic, caused by microorganisms like bacteria and virus, wreak havoc shaking human civilization with its rapid infection rate, and high number of mortalities. In case of a contagious disease, the virus can survive on any surface over a period of time and can be transferred to the human host through touching those surfaces unknowingly. Cleaning those possible surfaces to which these microorganisms can cling onto is one of the major ways to curb the spread. The aim of this study was to design a sterilizer which can clean such surfaces of daily used items easily within a certain period of time and can assess the cleaning efficacy by estimating the presence of microbes before and after sanitization.

Method development
To achieve this goal, we propose a portable sterilization unit that contains a sterilization chamber fitted with a microbe content detector. The sterilization chamber will cleanse the surfaces off the microbes using ultraviolet radiation. The chamber can be portable and at the same time big enough to accommodate items of daily use, like watch, wallet, clothes, utensils to even foods for single-house application. The microbe content detector will detect the success of the sterilization procedure by examining the time-lapse laser speckle images captured by a high-speed camera by mean of image processing algorithm, such that the user can determine whether further sterilization is required.

Conclusions
Microbe content detection device associated with the conventional sterilization procedure will give an assessment of the effectiveness of the sterilization. Successful implementation of sterilization for a wide variety of items of everyday use aided with microbe content detection technique is first of its kind and should be an effective tool for use in large communities, offices and public places for effective sterilization to help fight against the spread of infectious diseases.
Psychometric properties of the Porto Saudade Scale
Authors: Neto Félix 
Published: February 2021

AbstractSaudade involves psychosocial reactions to several circumstances involving deprivation from loved people and/or familiar locations. This work concerns the development and preliminary validation of an instrument to assess general disposition to saudade, the Porto Saudade Scale (PSS). Three studies were conducted which indicated that the PSS has favorable psychometric properties. Exploratory factor analysis of the PSS demonstrated a single latent saudade factor. The confirmatory factor analysis showed that the single latent model of the PSS is adequate and possesses good internal consistency. As expected, the data also supported the convergent, discriminant, and external validity of the PSS. Saudade was more frequently reported among females than among males. These results suggest the validity of the PSS and emphasize that it is a brief measure with strong psychometric evidence for assessing saudade.
The influence of density in population dynamics with strong and weak Allee effect
Authors: Keya Kamrun Nahar , Kamrujjaman Md. , Islam Md. Shafiqul 
Published: February 2021

AbstractIn this paper, we consider a reaction–diffusion model in population dynamics and study the impact of different types of Allee effects with logistic growth in the heterogeneous closed region. For strong Allee effects, usually, species unconditionally die out and an extinction-survival situation occurs when the effect is weak according to the resource and sparse functions. In particular, we study the impact of the multiplicative Allee effect in classical diffusion when the sparsity is either positive or negative. Negative sparsity implies a weak Allee effect, and the population survives in some domain and diverges otherwise. Positive sparsity gives a strong Allee effect, and the population extinct without any condition. The influence of Allee effects on the existence and persistence of positive steady states as well as global bifurcation diagrams is presented. The method of sub-super solutions is used for analyzing equations. The stability conditions and the region of positive solutions (multiple solutions may exist) are presented. When the diffusion is absent, we consider the model with and without harvesting, which are initial value problems (IVPs) and study the local stability analysis and present bifurcation analysis. We present a number of numerical examples to verify analytical results.
In vivo anti-inflammatory, antipyretic, analgesic activity and in vitro anti-proliferative activity of aqueous methanolic extract of Euphorbia granulata Forssk
Authors: Ghauri Mohsin Ahmad , Iqbal Liaqat , Raza Ali , Hayat Uzma , Atif Naveel , Javeed Aqeel 
Published: February 2021

AbstractBackgroundNaturally occurring substances of plant origin have long been used in folk medicine for curing various ailments including fever, pain, and inflammation etc. After careful evaluation on scientific bases, a large number of those substances provides cheaper alternative to currently used synthetic or semi-synthetic agents. Thus, with an aim of discovering alternative medicine for treatment of such ailments, current study was carried out.Euphorbia granulataForssk. had long been used as a therapeutic agent against various morbid conditions, e.g., anthelmintic, snake bite, scorpion sting, purgative, and diuretic, and as blood purifying agent in folk medicine. The purpose of the current study was to determine the extended therapeutic use ofEuphorbia granulataForssk. based upon scientific evaluation, to explore the potential of its anti-proliferative, analgesic, antipyretic, and anti-inflammatory activities while using an aqueous methanol extract of the whole plant.ResultsIn vivo study was performed on female rats of specieRattus norvegicusweighing (100–150 g). Anti-inflammatory activity of the plant extract was calculated against using carrageenan induced paw edema. Analgesic potential both central and peripheral was assessed by using Eddy’s hot plate method and acetic acid-induced writhing model, respectively. The antipyretic potential was appraised using brewer’s yeast suspension, injected under the nape of the neck, and body temperature was measured using a digital thermometer. The plant extract strengths used for in vivo experiments were 50 mg, 100 mg, and 200 mg/kg (diluted in normal saline) and were administered through intra-peritoneal route. MTT assay was performed to estimate in vitro anti-proliferative potential. For this assay, a serial dilution of the plant extract was used with 100 μg/ml as the highest concentration. In vivo results demonstrated that plant extract at dose strength of 200 mg/kg, showed significant (p* < 0.05) anti-inflammatory, analgesic, and antipyretic activities. In case of MTT assay, however, no significant anti-proliferative activity (p> 0.05) was observed up to 100 μg/ml dose strength.ConclusionIt can be concluded that aqueous methanol extract of Euphorbia granulata (whole plant) have shown significant anti-inflammatory, analgesic, and anti-pyretic activity in animal model. Therefore it can be a potential candidate, as a therapeutic alternative against treatment of algesia, pyrexia, and inflammation of various pathological origin. However, the plant extract did not demonstrate any significant anti-proliferation activity at doses used in this study.
Geographic influence on postoperative complications in children with complicated appendicitis: a single center study
Authors: Seqsaqa Mohammad , Rozeik Ahmed Ezzat , Khalifa Mohammed , Ashri Hazem Nour Abdellatif 
Published: February 2021

Abstract
Background
Acute appendicitis is one of the most common abdominal emergencies in children. Complicated appendicitis is much more common in pediatric age group than in adults due to probability of delay in diagnosis or misdiagnosis. Geographic status has an influence on the clinical course of such surgical cases. This prospective comparative study was conducted at the pediatric surgery department in our hospital in Egypt during the period from December 2018 to August 2019, aiming to find the relation between residence of patients and occurrence of post-operative complications among patients in Sharkia Governorate, Egypt. Patients were divided into two groups: rural and urban. Data recorded included demographic data, preoperative assessment, operative findings, postoperative course, postoperative complications, and follow-up.

Results
Sixty patients were included in the study, 32 of them were from rural areas, and 28 were from urban areas. There was no significant difference between them regarding demographics. Duration of symptoms was significantly longer with rural group (3.7 ± 1.4 vs. 3.07 ± 0.92 days). Length of hospital stay was significantly longer with the rural group (4.7 ± 1.7 vs. 4.7 ± 1.7 days). The rate of wound infection was significantly higher with the rural group (34.37% vs. 10.7%), while other postoperative complications were increased with rural group, but that was not statistically significant. The regularity of follow-up was higher with the urban group.

Conclusions
Children with complicated appendicitis from rural areas are at higher risk for occurrence of postoperative complications and poor outcome, with less regularity in follow-up. This is because of many obstacles they faced, including difficulties of transportation, insufficient medical services, and low socioeconomic and educational statuses.
Geophysical pore type inversion in carbonate reservoir: Integration of cores, well logs, and seismic data (Yadana field, offshore Myanmar)
Authors: Teillet Thomas , Fournier François , Zhao Luanxiao , Borgomano Jean , Hong Fei 
Published: February 2021

Detection of pore types and diagenetic features from seismic data is a major challenge for the evaluation of carbonate reservoirs in the subsurface. Based on a detailed petrographical and petrophysical analysis of carbonate rock using optical and scanning electron microscopy, mercury-injection measurements, digital image analysis, and well logs, we have determined the potential of the geophysical pore type ([Formula: see text]) inversion — a rock physics inversion scheme based on the differential effective medium theory—to quantitatively and qualitatively characterize the pore type distribution from acoustic data in the Yadana carbonate gas field (Early Miocene, offshore Myanmar). The geophysical pore type ([Formula: see text]) is revealed to be an upscalable parameter, whose depositional/diagenetic interpretation may be performed at well log and at seismic scales. We apply the inversion method on a 3D seismic data to map the reservoir-scale distribution and highlight the occurrence of laterally extended (100–1000 m) subseismic- to seismic-scale (thickness [Formula: see text]) geologic bodies. From this approach, two main reservoir geobodies are discriminated and interpreted in terms of depositional and diagenetic fabrics: (1) highly microporous, decameter-scale reservoir units (approximately 80% of the reservoir), mainly consisting of foraminiferal, red algae floatstone to rudstone with vuggy moldic porosity and characterized by moderate to high [Formula: see text] (0.11–0.20) and (2) thin, stratiform, cemented scleractinian floatstone/brecciated units (5–10 m; approximately 20% of the reservoir) with low microporosity and macroporosity and exhibiting low [Formula: see text] values ([Formula: see text]).
Five-Year Cancer Epidemiology at the National Referral Hospital: Hospital-Based Cancer Registry Data in Indonesia
Authors: Gondhowiardjo Soehartati , Christina Nadia , Ganapati Ngakan P.D. , Hawariy Salik , Radityamurti Fahmi , Jayalie Vito F. , Octavianus Steven , Prawira Putra Andre , Sekarutami Sri M. , Prajogi Gregorius B. , Giselvania Angela , Adham Marlinda , Hamid Agus R.A.H. , Widyastuti Endang , Prabowo Yogi , Aninditha Tiara , Purwoto Gatot , Aman Renindra A. , Siregar Trifona P. , Siswoyo Alvita Dewi , Handjari Diah R. , Atmakusuma Djumhana , Rajabto Wulyo , Mulansari Nadia A. , Ratna Nurul , Pitoyo Ceva W. , Panigoro Sonar Soni , Kartini Diani , Yulian Erwin D. , Andrisa Rossalyn S. , Jeo Wifanto S. , Wardhani Rizky K. , Tambunan Tresia F.U. , Agianda Feranindhya 
Published: February 2021

PURPOSE In 2016, there were 1,308,061 cases of cancer being treated in Indonesia, with 2.2 trillion rupiahs spent, amounting to $486,960,633 in US dollars (purchasing power parity 2016). The high burden of cancers in Indonesia requires a valid data collection to inform future cancer-related policies. The purpose of this study is to report cancer epidemiological data from 2008 to 2012 based on Hospital-Based Cancer Registry (HBCR) data from Cipto Mangunkusumo Hospital, Indonesia. METHODS This was a descriptive study with cross-sectional design. Data were collected from Cipto Mangunkusumo Hospital HBCR 2008-2012. Demographical, diagnostic, stages of cancer, and histopathological types of cancer data were extracted. RESULTS After screening, 18,216 cases were included. A total of 12,438 patients were older than 39 years of age (68.3%), with a female-to-male ratio of 9:5. Most patients have cancers at advanced stages (stages III and IV, 10.2%). The most common sites of cancer were cervix uteri (2,878 cases, 15.8%), breast (2,459 cases, 13.5%), hematopoietic and reticuloendothelial systems (1,422 cases, 7.8%), nasopharynx (1,338 cases, 7.4%), and lymph nodes (1,104 cases, 6.1%). CONCLUSION From this HBCR, cancer incidence in female was almost twice the incidence in male, largely because of the burden of cervical and breast cancers. The cervix uteri as one of the top five cancer sites based on this HBCR, 2008-2012, are still approximately consistent with Global Cancer Incidence, Mortality and Prevalence 2018, which portrayed that Indonesia has been severely afflicted by cervical cancer cases more than any other Association of Southeast Asian Nations countries. The HBCR could serve as a robust database of epidemiological data for cancer cases in Indonesia.
Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes
Authors: Bersanelli Matteo , Travaglino Erica , Meggendorfer Manja , Matteuzzi Tommaso , Sala Claudia , Mosca Ettore , Chiereghin Chiara , Di Nanni Noemi , Gnocchi Matteo , Zampini Matteo , Rossi Marianna , Maggioni Giulia , Termanini Alberto , Angelucci Emanuele , Bernardi Massimo , Borin Lorenza , Bruno Benedetto , Bonifazi Francesca , Santini Valeria , Bacigalupo Andrea , Voso Maria Teresa , Oliva Esther , Riva Marta , Ubezio Marta , Morabito Lucio , Campagna Alessia , Saitta Claudia , Savevski Victor , Giampieri Enrico , Remondini Daniel , Passamonti Francesco , Ciceri Fabio , Bolli Niccolò , Rambaldi Alessandro , Kern Wolfgang , Kordasti Shahram , Sole Francesc , Palomo Laura , Sanz Guillermo , Santoro Armando , Platzbecker Uwe , Fenaux Pierre , Milanesi Luciano , Haferlach Torsten , Castellani Gastone , Della Porta Matteo G. 
Published: February 2021

PURPOSE Recurrently mutated genes and chromosomal abnormalities have been identified in myelodysplastic syndromes (MDS). We aim to integrate these genomic features into disease classification and prognostication. METHODS We retrospectively enrolled 2,043 patients. Using Bayesian networks and Dirichlet processes, we combined mutations in 47 genes with cytogenetic abnormalities to identify genetic associations and subgroups. Random-effects Cox proportional hazards multistate modeling was used for developing prognostic models. An independent validation on 318 cases was performed. RESULTS We identify eight MDS groups (clusters) according to specific genomic features. In five groups, dominant genomic features include splicing gene mutations ( SF3B1, SRSF2, and U2AF1) that occur early in disease history, determine specific phenotypes, and drive disease evolution. These groups display different prognosis (groups with SF3B1 mutations being associated with better survival). Specific co-mutation patterns account for clinical heterogeneity within SF3B1- and SRSF2-related MDS. MDS with complex karyotype and/or TP53 gene abnormalities and MDS with acute leukemia–like mutations show poorest prognosis. MDS with 5q deletion are clustered into two distinct groups according to the number of mutated genes and/or presence of TP53 mutations. By integrating 63 clinical and genomic variables, we define a novel prognostic model that generates personally tailored predictions of survival. The predicted and observed outcomes correlate well in internal cross-validation and in an independent external cohort. This model substantially improves predictive accuracy of currently available prognostic tools. We have created a Web portal that allows outcome predictions to be generated for user-defined constellations of genomic and clinical features. CONCLUSION Genomic landscape in MDS reveals distinct subgroups associated with specific clinical features and discrete patterns of evolution, providing a proof of concept for next-generation disease classification and prognosis.
Optimal use of tocilizumab for severe and critical COVID-19: a systematic review and meta-analysis
Authors: Nugroho Cahyo Wibisono , Suryantoro Satriyo Dwi , Yuliasih Yuliasih , Rosyid Alfian Nur , Asmarawati Tri Pudy , Andrianto Lucky , Setiawan Herley Windo , Mahdi Bagus Aulia , Windradi Choirina , Agustin Esthiningrum Dewi , Fajar Jonny Karunia 
Published: February 2021

Background: Several studies have revealed the potential use of tocilizumab in treating COVID-19 since no therapy has yet been approved for COVID-19 pneumonia. Tocilizumab may provide clinical benefits for cytokine release syndrome in COVID-19 patients. Methods: We searched for relevant studies in PubMed, Embase, Medline, and Cochrane published from March to October 2020 to evaluate optimal use and baseline criteria for administration of tocilizumab in severe and critically ill COVID-19 patients. Research involving patients with confirmed SARS-CoV-2 infection, treated with tocilizumab and compared with the standard of care (SOC) was included in this study. We conducted a systematic review to find data about the risks and benefits of tocilizumab and outcomes from different baseline criteria for administration of tocilizumab as a treatment for severe and critically ill COVID-19 patients. Results: A total of 26 studies, consisting of 23 retrospective studies, one prospective study, and two randomised controlled trials with 2112 patients enrolled in the tocilizumab group and 6160 patients in the SOC group, were included in this meta-analysis. Compared to the SOC, tocilizumab showed benefits for all-cause mortality events and a shorter time until death after first intervention but showed no difference in hospital length of stay. Upon subgroup analysis, tocilizumab showed fewer all-cause mortality events when CRP level ≥100 mg/L, P/F ratio 200-300 mmHg, and P/F ratio <200 mmHg. However, tocilizumab showed a longer length of stay when CRP <100 mg/L than the SOC. Conclusion: This meta-analysis demonstrated that tocilizumab has a positive effect on all-cause mortality. It should be cautiously administrated for optimal results and tailored to the patient's eligibility criteria.
Using DHS and MICS data to complement or replace NGO baseline health data: an exploratory study
Authors: Berti Peter R. , Nardocci Milena , Tran Minh Hung , Batal Malek , Brodmann Rebecca , Greliche Nicolas , Saville Naomi M. 
Published: February 2021

Background: Non-government organizations (NGOs) spend substantial time and resources collecting baseline data in order to plan and implement health interventions with marginalized populations. Typically interviews with households, often mothers, take over an hour, placing a burden on the respondents. Meanwhile, estimates of numerous health and social indicators in many countries already exist in publicly available datasets, such as the Demographic and Health Surveys (DHS) and the Multiple Indicator Cluster Surveys (MICS), and it is worth considering whether these could serve as estimates of baseline conditions. The objective of this study was to compare indicator estimates from non-governmental organizations (NGO) health projects’ baseline reports with estimates calculated using the Demographic and Health Surveys (DHS) or the Multiple Indicator Cluster Surveys (MICS), matching for location, year, and season of data collection. Methods: We extracted estimates of 129 indicators from 46 NGO baseline reports, 25 DHS datasets and three MICS datasets, generating 1,996 pairs of matched DHS/MICS and NGO indicators. We subtracted NGO from DHS/MICS estimates to yield difference and absolute difference, exploring differences by indicator. We partitioned variance of the differences by geographical level, year, and season using ANOVA. Results: Differences between NGO and DHS/MICS estimates were large for many indicators but 33% fell within 5% of one another. Differences were smaller for indicators with prevalence <15% or >85%. Difference between estimates increased with increasing year and geographical level differences. However, <1% of the variance of the differences was explained by year, geographical level, and season. Conclusions: There are situations where publicly available data could complement NGO baseline survey data, most importantly when the NGO has tolerance for estimates of low or unknown accuracy.