bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetics and Phenotypic Analysis of First Lactation Production, Reproduction and Part Lactation Traits in Frieswal Cattle
Authors: . Rajeev , Kumar Ravinder 
Published: February 2021

Background: The Frieswal cattle a crossbred cattle breed having 62.50 per cent of exotic (inheritance) having total lactation milk yield of 4000 Kg with average lactation length 300 days (PDC Annual Report, 2015-16). Presently, the Frieswal Animal is mainly maintained at 36 Military Farms located in various agro-climatic regions in the country. Methods: The present study was undertaken on first Part lactation production, reproduction and part lactation records of 1470 Frieswal cows maintained over a period of 10 years (2003-2012) two military farms viz Meerut and Ambala at CIRC, Meerut. Result: The estimate the heritability of production and reproduction traits were 0.29 ±0 .098,0.142±.081, 0.130±0.079, 0.087 ±.074, 0.631 ± 0.255, 0.345 ± 0.247 and 0.100 ± 0.153 for standard 305 days milk yield, age of first calving (AFC), First lactation total milk yield (FLMY), First lactation 305-day or less milk yield (FL305DMY), First lactation length (FLL), Inter calving interval (ICI), First dry period (FDP), First Service Period (FSP), respectively. All the genetic and phenotypic correlation among different production and reproduction traits were high and positive. The estimates of heritability of first lactation individual part monthly yields in Frieswal cattle were found to be 0.100 ± 0.069, 0.105 ± .070, 0.100 ± 0.069, 0.112 ± 0.071, 0.204 ± 0.086, 0.160±0.079, 0.176 ± 0.081, 0.221 ± 0.088, 0.213 ± 0.087 and 0.192 ± 0.09, respectively.
MINAT PEMUDA PADA PERTANIAN HORTIKULTURA DI DESA KELOR KECAMATAN KARANGMOJO KABUPATEN GUNUNGKIDUL
Authors: Ningtyas Adriana Sharadhea , Santosa Bambang 
Published: February 2021

<p>Youth is a valuable asset to the country. The success of the nation's development depends on the level of its youth participation. Phenomena declining the interest of youth in agriculture is a special concern for society and government. Amid in the youth interest in the agricultural sector work, there is a group of farmers who have an interest in agriculture, especially horticultural. The purpose of this research is to see the process of increasing youth interest in horticultural farming, a factor that affects youth interest and the process of forming rational youth choices related to increased interest in horticultural farming. Qualitative research with a descriptive exploratory approach was conducted in the village Kelor Karangmojo District in Gunungkidul Regency. Sampling techniques using purposive sampling techniques. As for the research, informant consists of the youths who belong in a group of horticultural farmer Youth, non-village youth groups and village devices. Data is collected by observing, post conducting interviews and documentation. To test the data validity using source triangulation. Data analysis techniques use interactive models of Miles and Huberman with the rational choice theory of James S. Coleman.</p><p>The results showed the process of increasing youth interest through: increased youth involvement in horticultural farms that are differentiated into direct involvement and supporting involvement about concerning frequency, long farmed and The youth-owned land area; Increased members of Horticulture Farmer Youth Group; Raising horticultural farmland; and increased youth innovations in horticultural farming. In the factors that affect the interest of the driving factor is the inner urge, social motivation, and emotional factor also the traction factor in the form of economic factors and market availability. The rational choice of youth against horticultural farming occurs because of the objectives that youths want to achieve by doing horticultural farming activities. Youth access to natural resources as well as capital is a tool for youth to get their goals. In maximizing the efforts of youth conduct collective behavior that is by forming a group of agriculture that has access to human resources and capital resources that can overcome the limitations of youth actors of individuals in activities Horticultural farming.</p>
APLIKASI SYIRKAH BERBASIS BAGI HASIL TANGKAPAN IKAN NELAYAN: PERSPEKTIF SOSIAL EKONOMI
Authors: Malahayatie Malahayatie , Suryani Suryani 
Published: February 2021

Fenomena kemiskinan yang dialami oleh sebagian nelayan pesisir pantai Lhokseumawe disebabkan faktor ekonomi dan sosial, sehingga para nelayan tidak mampu mendapatkan pendapatan yang layak dan akses pendidikan yang memadai. Penelitian ini bertujuan untuk mengetahui praktik bagi hasil tangkapan ikan nelayan, aplikasi syirkah pada praktik bagi hasil tersebut di kalangan nelayan Kota Lhokseumawe serta melihat berbagai fenomena kemiskinan pada nelayan di Kecamatan Banda Sakti, kota Lhokseumawe Aceh. Metode dalam penelitian ini menggunakan metode kualitatif deskriptif dengan melakukan penelitian lapangan. Hasil penelitian mengungkapkan bahwa praktik bagi hasil tangkapan ikan yang ada dikalangan nelayan Kecamatan Banda Sakti melibatkan dua pihak sebagai pemberi modal yaitu toke boat dan toke bangku dan selanjutnya di kelola oleh pihak rakan meupakat beserta pawang (nahkoda laut). Aplikasi syirkah terletak pada kerjasama dan kesepakatan dari percampuran modal kedua pihak toke boat dan toke bangku yang kemudian dikelola bersama dengan pihak pengelola. [The phenomena related to the poverty experienced by most fishermen in the coastal areas of Lhokseumawe were caused by the economic and sosial factors. Thus, the fisherman were then unable to obtain reasonable income and adequate education. This research aims at revealing the profit sharing and syirkah (cooperation) practices related to the fish caught by the local fishermen in Lhokseumawe as well as the phenomena of poverty experienced by the fishermen in Banda Sakti sub-district of Lhokseumawe. This research used a descriptive-qualitative method with various research fields. The results of this research showed that the profit sharing practices related to the fish caught by the local fishermen in Lhokseumawe involved both parties consisting of capital providers called toke boet (boat owner) and toke bangku (capital owner) which were then managed by the rakan meupakat and pawang. The syirkah was practiced due to the cooperation and agreement related to the boat and capital made by toke boet and toke bangku which were mutually managed by the managers until the processes of fish caught by the local fishermen were well completed.]
MURĀ’AH MUZAKKI PADA ZAKAT PERTANIAN DAN PERKEBUNAN DALAM PANDANGAN AL-QARADHAWI
Authors: Ainiah Ainiah 
Published: February 2021

Tujuan utama fundraising zakat adalah peningkatan realisasi potensi zakat untuk mewujudkan kesejahteraan mustahik zakat sehingga mereka bisa menjadi muzakki di masa yang akan datang. Tujuan ini menjadikan kegiatan fundraising lebih cenderung memperhatikan keadaan mustahik zakat dan mengenyampingkan keadaan muzakki sehingga terkesan tidak seimbang antara kedua belah pihak (muzakki dan mustahik zakat). Penelitian ini bertujuan untuk menelusuri beberapa pertimbangan keadaan dan situasi (murā’ah) terhadap muzakki khususnya dalam zakat pertanian dan perkebunan yang dilakukan oleh Al-Qaradhawi sehingga mempengaruhi penetapan hukum (istinbaṭ aḥkām), tarjīh atau menguatkan hukum yang telah ada. Penelitian ini merupakan penelitian pustaka dengan analisis isi dari rujukan utama kitab “Fiqh al-Zakāh” karya Syeikh Yusuf Al-Qaradhawi. Temuan penelitian menunjukkan bahwa Al-Qaradhawi berpijak pada murā’ah muzakki dalam menguatkan hukum yang telah ada seperti kepemilikan penuh, kadar zakat yang wajib ditunaikan bergantung pada irigasi, waktu perhitungan nisab dan menunaikan zakat. Selain menguatkan hukum, Al-Qaradhawi juga men-tarjīh pendapat, diantaranya pengurangan al-matlūbat al-hallah sebelum perhitungan nisab. Al-Qaradhawi juga mempunyai sikap untuk menetapkan hukum yang tidak tertera dalam Nash berdasarkan murā’ah muzakki yaitu menetapkan kadar wajib zakat sebesar 7,5% bagi yang mengalami keseimbangan antara pemakaian irigasi dengan beban dan tadah hujan (tanpa beban). [The main goal of zakah fundraising is to increase the realization of zakah potential to create the mustahik zakah’s welfare so that they can become muzakki in the future. This goal makes fundraising activities tend to pay attention to the condition of mustahik zakat instead of the condition of muzakki so that it seems unbalanced between the two parties (muzakki and mustahik zakah). This study aims to explore several considerations of circumstances and situations (murā'ah) to muzakki, especially in agricultural zakah that is carried by Al-Qaradhawi that affects the legal establishment (istinbaṭ aḥkām), tarjīh or strengthens the existing laws. This research is library research with content analysis from the book of "Fiqh al-Zakāh" by Syeikh Yusuf Al-Qaradhawias as the main reference. The findings show that Al-Qaradhawi stood on murā'ah muzakki in strengthening existing laws such as full ownership, the amount of zakah to be paid that depends on irrigation, and time in calculating nisab and paying it. In addition, to strengthening the existing laws, Al-Qaradawi also did tarjih the opinions, among of them is the reduction of al-matlūbat al-hallah before calculating the nisab. Al-Qaradhawi also has a legal stance to stipulate a law based on murā'ah muzakki that is not stated in Nash, which is to determine the compulsory level of zakat at 7.5% for those who experience both cost irrigation and non-cost irrigation, equally.]
SIESTA as a universal unbiased proteomics approach for identification and prioritization of enzyme substrates&nbsp;
Authors: Saei Amir Ata , Beusch Christian M. , Sabatier Pierre , Wells Juan Astorga , Gharibi Hassan , Meng Zhaowei , Chernobrovkin Alexey , Rodin Sergey , Näreoja Katja , Thorsell Ann-Gerd , Karlberg Tobias , Cheng Qing , Lundström Susanna L. , Gaetani Massimiliano , Végvári Ákos , Arnér Elias S.J. , Schüler Herwig , Zubarev Roman A. 
Published: February 2021

Abstract
This protocol describes the proteomics technique called System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis or SIESTA 1,2. SIESTA can be used for universal discovery of enzyme substrates that shift in thermal stability or solubility upon post-translational modification (PTM). Experimental design, proteomics sample preparation and data analysis are the key stages of this protocol. Data analysis can be performed using our SIESTA package hosted on GitHub 3. When performed with classical thermal proteome profiling (TPP), the protocol will take 5 days for sample preparation and 14 days of sample analysis by mass spectrometry (the current protocol). If our high-throughput version of TPP called Proteome Integral Solubility Alteration assay (PISA) 4 is used instead, the sample analysis time by mass spectrometry is reduced to 1-2 days for the same number of conditions.
Metabolic turnover and dynamics of RNA modifications by 13C labelling
Authors: Gameiro Paulo A , Foskolou Iosifina P , Encheva Vesela , Santos Mariana Silva dos , MacRae James I , Johnson Randall S , Ule Jernej 
Published: February 2021

Abstract
RNA methylation regulates various aspects of RNA metabolism, and dynamic modulation ofRNA modifications has emerged as a major effector in cellular transitions. Yet, we lack quantitativemethods to comprehensively assess methylation dynamics, its features and regulatory inputs, acrossRNA modifications. We developed 13C-dynamods, an isotopic labelling approach using [13C-methyl]-methionine, to quantify the turnover of base modifications in newly synthesized RNA. This turnover-basedapproach resolved the contributions of mRNA vs. ncRNA modifications within polyadenylatedRNA and uncovered the distinct kinetics of N6-methyladenosine (m6A) and 7-methylguanosine (m7G)in mRNA. Moreover, we obtained converging evidence indicating presence of N6,N6-dimethyladenosine (m62A) in non-ribosomal RNA, in particular tRNA and rapidly decaying RNAs.Finally, we showed that mRNA methylation dynamics is coordinated with ribonucleotide biosynthesisduring T-cell activation, and revealed post-transcriptional lability of m6A upon metabolic stress. Thus,13C-dynamods enables studies of origin, maintenance and regulation of RNA modifications understeady-state and non-stationary conditions.
Smartphone Based Alerting of First Responders During the COVID-19 Pandemic
Authors: Ganter Julian , Damjanovic Domagoj , Trummer Georg , Busch Hans-Jörg , Baldas Klemens , Hänsel Mike , Müller Michael Patrick 
Published: February 2021

Abstract
Background: Smartphone Alerting Systems (SAS) for first responders potentially shorten the resuscitation-free interval of patients with acute cardiac arrest. During the COVID-19 pandemic, many systems were suspended due to potential risks for the responders. Therefore, a COVID-19 concept for the SAS in Freiburg/Germany was established and evaluated.
Methods: Due to the pandemic, SAS was stopped in March 2020. A concept for a safe restart was elaborated with provision of a set with ventilation bag/mask, airway filter and personal protective equipment (PPE) for every volunteer. A standard operating procedure followed the COVID-19 guidelines of the European Resuscitation Council (ERC). Willingness of the participants to respond alarms during the pandemic was investigated using an online survey.
Results: The system was restarted in May 2020. The willingness to respond to alarms was lower during the pandemic without PPE. It remained lower than before the pandemic when the volunteers had been equipped with PPE, but the alarm response rate remained at approximately 50% during the ongoing pandemic.
Conclusions: When volunteers are equipped with PPE, the operation of a SAS does not need to be paused, and the willingness to respond remains high among first responders.
The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population
Authors: Liang Tiebiao , Zhang Xianbo , Liang Anshan , Wu Haiqing , Wang Qi , He Jun , Long Ming , Jin Tianbo 
Published: February 2021

Abstract
Background Coronary heart disease (CHD) is the leading cause of human death worldwide. Genetic factors play an important role in the occurrence of CHD. Our study is designed to investigate the influence of CYP7B1 polymorphisms on CHD risk.Methods In this case-control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between CYP7B1 polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses.Results Our study found that rs6472155 is significantly associated with an increased risk of CHD in age > 60 years (OR 2.20, 95 % CI = 1.07–4.49, p = 0.031), women (OR 3.17, 95 % CI = 1.19–8.44, p = 0.021), and non-smokers (3.43, 95 % CI = 1.16–10.09, p = 0.025). Rs2980003 polymorphism has a lower risk of CHD in drinkers (OR 0.47, 95 % CI = 0.24–0.91, p = 0.025). Besides, it was found that rs6472155 polymorphism was associated with uric acid level (p = 0.034).Conclusion Our study indicated that CYP7B1 polymorphisms are related to the risk of CHD, which provides a new perspective for prevent of CHD.
Clinical evaluation of rapid point of care antigen tests for diagnosis of SARS-CoV-2 infection
Authors: Koeleman Johannes G.M. , Brand Henk , Man Stijn J. de , Ong David 
Published: February 2021

Abstract
Purpose: The RT-qPCR in respiratory specimens is the gold standard for diagnosing acute COVID-19 infections. However, this test takes considerable time before test results become available, thereby delaying diagnosed COVID-19 patients to be treated and isolated immediately. Rapid antigen tests could overcome this problem and therefore a large number of COVID-19 rapid antigen tests have been developed. Methods: In this study clinical performances of five rapid antigen tests were compared to RT-qPCR in upper respiratory specimens from 80 patients. In addition, the rapid antigen test with the best test characteristics (Romed) was evaluated in a large prospective collection of randomly selected upper respiratory specimens from 900 different COVID-19 suspected patients (300 emergency room patients, 300 nursing home patients and 300 health care workers) in the period from October 24 to November 15, 2020. Results: Overall specificity was almost 100% and sensitivity ranged from 55.0% to 80.0%. The clinical specificity of the Romed test was 99.8% (95% CI 98.9-100). Overall clinical sensitivity in the study population was 73.3% (95% CI 67.9-78.2), whereas sensitivity in the different groups varied from 65.3% to 86.7%. Sensitivity was highest in patients with short-term symptoms. In a population with a COVID-19 prevalence of 1% the negative predictive value in all patients was 99.7%. Conclusion: There is a large variability in diagnostic performance between rapid antigen tests. The Romed rapid antigen test showed a good clinical performance in patients with high viral loads, which makes this antigen test suitable for rapid identification of COVID-19 infected patients.
Impact of a dementia-friendly program on detection and management of patients with cognitive impairment and delirium in acute-care hospital units: a non-equivalent control group design
Authors: Weldingh Nina , Mellingsæter Marte , Hegna Bendik , Benth Jūratė Šaltytė , Einvik Gunnar , Juliebø Vibeke , Thommessen Bente , Kirkevold Marit 
Published: February 2021

Abstract
Background
Frail older persons with cognitive impairment (CI) are at special risk of experiencing delirium during acute hospitalisation.
The purpose of this study was to
investigate whether a dementia-friendly hospital program
contributes to improved detection and management of patients with
CI and risk of delirium at an acute-care hospital in Norway.
Furthermore, we aimed to explore whether the program affected the prevalence of delirium, pharmacological treatment, 30-day re-hospitalisation, 30-day mortality and institutionalisation afterwards.
Methods
This study had a non-equivalent control group design and a historical control group. It was conducted at two different medical wards at a large acute-care hospital in Norway from September 2018 to December 2019. A total of 423 acute hospitalised patients 75 years of age or older were included in the study. Delirium screening and cognitive tests were recorded by research staff with the Four Assessment Test (4AT) and the Confusion Assessment Measure (CAM), while demographic and medical information was recorded from patient journals.
Results
Implementation of the dementia-friendly hospital program did not show any significant effect on the identification of patients with CI. However, the proportion of the patients with CI who received preventive measures increased by 32.2% (P < .001), compared to the control group. The share of patients screened with 4AT within 24 hours increased from 0–35.5% (P < .001). Furthermore, the number of patients with CI who were prescribed antipsychotic/hypnotic medications was reduced by 24.5% (P < .001). There were no differences in delirium, 30-day readmission or 30-day mortality.
Conclusions
Implementation of a model for early screening and multifactorial nonpharmacological interventions for patients with CI and delirium using quality improvement methodology may improve management of this patient group, increase staff awareness of family involvement, and reduce prescriptions of antipsychotics, hypnotics and sedatives.
Trial registration:
The protocol of this study was retrospectively registered in the ClinicalTrials.gov Protocol Registration and Results System with the registration number: NCT04737733 and date of registration: 03/02/2021.
Regorafenib combined with transarterial chemoembolization for unresectable hepatocellular carcinoma: a real world study
Authors: Han Yue , Cao Guang , Sun Bin , Wang Jian , Yan Dong , Xu Haifeng , Shi Qinsheng , Liu Zechuan , Zhi Weihua , Xu Liang , Liu Bojun , Zou Yinghua 
Published: February 2021

Abstract
Background: The benefits and tolerability of transarterial chemoembolization (TACE) combined with regorafenib as a second-line therapy has not been reported for unresectable hepatocellular carcinoma (HCC). To explore the benefits and tolerability of TACE combined with second-line regorafenib in patients with unresectable advanced HCC and failure to first-line treatment.Methods: This was a multicenter retrospective study of patients with progression after first-line sorafenib and/or lenvatinib between 01/2019 and 04/2020 at four tertiary hospitals in China. The patients were treated with TACE. Then, 5-7 days after the first TACE, the patients started taking regorafenib for 3 weeks every 4-week cycles. The overall survival (OS), time to progression (TTP), progression-free survival (PFS), and adverse events (AEs) were observed.Results: The median follow-up was 5.6 (range: 0.7, 17.0) months. The median age was 60 (range: 35, 79) years. There were 32 (84.2%) males. The patients underwent a median of three TACE sessions (range, 1-13). The initial doses of regorafenib were 20 mg/d (n=1, 2.6%), 80 mg/d (n=10, 26.3%), 120 mg/d (n=15, 39.5%), and 160 mg/d (n=11, 28.9%). The incidence of grade 3/4 AEs was 15.8%. Two patients stopped regorafenib due to AEs. The median OS was 14.3 months. The median PFS and TTP were 9.1 (95% CI: 4.0, 14.2) and 9.1 (95% CI: 5.5, 12.8) months, respectively.Conclusions: The present study provides real-world evidence indicating that regorafenib combined with TACE was beneficial and tolerable in patients with unresectable HCC. Additional prospective large-scale studies are required for confirmation.