bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektifitas Metode Scramble Dalam Pembelajaran Pendidikan Agama Islam di SDN Balonggabus Sidoarjo
Authors: Hakim Femiliana 
Published: September 2021

Islamic religious education learning (PAI) at elementary school has been dominated teacher and is not conducted maximally. This causes students' attention less focused in the teaching and learning process. To overcme this problem, it needs an alternative learning method. This article is descriptive analytic using a qualitative approach. The data is collected used literature study. The research results indicate three things. The first is, the scramble method is a relatively new learning technique, it also makes students are actively involved in the teaching and learning process. The second is, PAI learning is still dominated by the teacher which causes students to be less active and resulted learning outcomes too low. The third is, the scramble method is very important to be applied in PAI learning for elementary schools. This is done to improve student learning outcomes and change the monotonous learning methods.
[Pembelajaran pendidikan agama Islam (PAI) pada jenjang sekolah dasar menunjukkan masih didominasi belum berlangsung secara maksimal. Hal ini menyebabkan perhatian siswa kurang fokus saat belajar di sekolah. Diperlukan metode pembelajaran alternatif untuk mengakhiri permasalahan ini. Artikel ini bersifat deskriptif-analitik dengan menggunakan pendekatan kualitatif. Pengumpulan datanya menggunakan studi kepustakaan. Hasil pembahasan tulisan ini menunjukkan kepada tiga hal. Pertama menunjukkan bahwa metode scramble adalah teknik pembelajaran yang tergolong baru dan mampu menjadikan siswa aktif dalam proses pembelajaran. Kedua adalah kondisi pembelajaran PAI selama ini masih didominasi oleh metode ceramah yang menyebabkan siswa kurang aktif sehingga hasil belajar siswa masih tergolong rendah. Ketiga adalah metode scramble semakin penting (urgent) untuk diterapkan dalam pembelajaran PAI pada sekolah dasar. Hal ini didorong keinginan untuk menaikkan hasil belajar siswa dan mengakhiri metode pembelajaran yang selama ini masih monoton]
Berpikir Reflektif Siswa Kelas V-A MI Tanwirul Fuad Sumberjo dalam Memecahkan Masalah Matematika Materi Pecahan
Authors: Yuanita Dianis Izztul , Muchib Azhari Mohamad 
Published: September 2021

So far, the tendency of mathematics teachers to not optimize students' mathematical thinking skills in learning, especially higher order thinking skills. One of the higher order thinking skills is reflective thinking. Reflective thinking is a directed and precise process in which individuals analyze, evaluate, motivate, gain deep meaning, using appropriate learning strategies. The reflective thinking ability according to Surbeck, Han and Moyer has 3 phases/levels, namely reacting, comparing, and contemplating. The purpose of this study was to describe students' reflective thinking skills in solving math problems with fractions in class V-A MI Tanwirul Fuad Sumberjo. As a source of data taken 6 students from 27 students. In this study data collection techniques used, namely tests, interviews and documentation. The data analysis technique used is qualitative data analysis with data reduction steps, data presentation, and drawing conclusions. Data analysis was carried out by: 1) presenting the data, 2) comparing the test result data with interviews conducted with students, and 3) concluding the data.
[Selama ini kecenderungan para guru matematika kurang mengoptimalkan kemampuan berpikir matematika siswa dalam pembelajaran, terutama kemampuan berpikir tingkat tinggi. Salah satu kemampuan berpikir tingkat tinggi adalah berpikir reflektif. Berpikir reflektif adalah proses terarah dan tepat dimana individu menganalisis, mengevaluasi, memotivasi, mendapatkan makna mendalam, menggunakan strategi pembelajaran yang tepat. Kemampuan berpikir reflektif menurut Surbeck, Han dan Moyer memiliki 3 fase/tingkatan yaitu reacting, comparing, dan contemplating. Tujuan dari penelitian ini adalah untuk mendeskripsikan kemampuan berpikir reflektif siswa dalam memecahkan masalah matematika materi pecahan di kelas V-A MI Tanwirul Fuad Sumberjo. Sebagai sumber data diambil 6 siswa dari 27 siswa. Dalam penelitian ini teknik pengumpulan data yang digunakan, yaitu tes, wawancara dan dokumentasi. Teknik analisis data yang digunakan yaitu analisis data kualitatif dengan langkah-langkah reduksi data, penyajian data, dan penarikan kesimpulan. Analisis data dilakukan dengan cara: 1) menyajikan data, 2) membandingkan data hasil tes dengan wawancara yang dilakukan terhadap siswa, dan 3) menyimpulkan data]
Using Immune-Related Long Non-coding Ribonucleic Acids to Develop a Novel Prognosis Signature and Predict the Immune Landscape of Colon Cancer
Authors: Wang Xu , Chen Ke , Wang Zhenglin , Xu Yuanmin , Dai Longfei , Bai Tao , Chen Bo , Yang Wenqi , Chen Wei 
Published: September 2021

Purpose: This study aimed to construct a novel signature to predict the survival of patients with colon cancer and the associated immune landscape, based on immune-related long noncoding ribonucleic acids (irlncRNAs).Methods: Expression profiles of irlncRNAs in 457 patients with colon cancer were retrieved from the TCGA database (https://portal.gdc.cancer.gov). Differentially expressed (DE) irlncRNAs were identified and irlncRNA pairs were recognized using Lasso regression and Cox regression analyses. Akaike information criterion (AIC) values of receiver operating characteristic (ROC) curve were calculated to identify the ideal cut-off point for dividing patients into two groups and constructing the prognosis signature. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to validate the expression of LINC02195 and SCARNA9 in colon cancer.Results: We identified 22 irlncRNA pairs and patients were divided into high-risk and low-risk groups based on the calculated risk score using these 22 irlncRNA pairs. The irlncRNA pairs were significantly related to patient survival. Low-risk patients had a significantly longer survival time than high-risk patients (p &lt; 0.001). The area under the curve of the signature to predict 5-year survival was 0.951. The risk score correlated with tumor stage, infiltration depth, lymph node metastasis, and distant metastasis. The risk score remained significant after univariate and multivariate Cox regression analyses. A nomogram model to predict patient survival was developed based on the results of Cox regression analysis. Immune cell infiltration status, expression of some immune checkpoint genes, and sensitivity to chemotherapeutics were also related to the risk score. The results of qRT-PCR revealed that LINC02195 and SCARNA9 were significantly upregulated in colon cancer tissues.Conclusion: The constructed prognosis signature showed remarkable efficiency in predicting patient survival, immune cell infiltration status, expression of immune checkpoint genes, and sensitivity to chemotherapeutics.
Zebrafish Embryo Infection Model to Investigate Pseudomonas aeruginosa Interaction With Innate Immunity and Validate New Therapeutics
Authors: Pont Stéphane , Blanc-Potard Anne-Béatrice 
Published: September 2021

The opportunistic human pathogen Pseudomonas aeruginosa is responsible for a variety of acute infections and is a major cause of mortality in chronically infected patients with cystic fibrosis (CF). Considering the intrinsic and acquired resistance of P. aeruginosa to currently used antibiotics, new therapeutic strategies against this pathogen are urgently needed. Whereas virulence factors of P. aeruginosa are well characterized, the interplay between P. aeruginosa and the innate immune response during infection remains unclear. Zebrafish embryo is now firmly established as a potent vertebrate model for the study of infectious human diseases, due to strong similarities of its innate immune system with that of humans and the unprecedented possibilities of non-invasive real-time imaging. This model has been successfully developed to investigate the contribution of bacterial and host factors involved in P. aeruginosa pathogenesis, as well as rapidly assess the efficacy of anti-Pseudomonas molecules. Importantly, zebrafish embryo appears as the state-of-the-art model to address in vivo the contribution of innate immunity in the outcome of P. aeruginosa infection. Of interest, is the finding that the zebrafish encodes a CFTR channel closely related to human CFTR, which allowed to develop a model to address P. aeruginosa pathogenesis, innate immune response, and treatment evaluation in a CF context.
Development and Validation of a Novel Nomogram for Preoperative Prediction of In-Hospital Mortality After Coronary Artery Bypass Grafting Surgery in Heart Failure With Reduced Ejection Fraction
Authors: Yan Pengyun , Liu Taoshuai , Zhang Kui , Cao Jian , Dang Haiming , Song Yue , Zheng Jubing , Zhao Honglei , Wu Lisong , Liu Dong , Huang Qi , Dong Ran 
Published: September 2021

Background and Aims: Patients with heart failure with reduced ejection fraction (HFrEF) are among the most challenging patients undergoing coronary artery bypass grafting surgery (CABG). Several surgical risk scores are commonly used to predict the risk in patients undergoing CABG. However, these risk scores do not specifically target HFrEF patients. We aim to develop and validate a new nomogram score to predict the risk of in-hospital mortality among HFrEF patients after CABG.Methods: The study retrospectively enrolled 489 patients who had HFrEF and underwent CABG. The outcome was postoperative in-hospital death. About 70% (n = 342) of the patients were randomly constituted a training cohort and the rest (n = 147) made a validation cohort. A multivariable logistic regression model was derived from the training cohort and presented as a nomogram to predict postoperative mortality in patients with HFrEF. The model performance was assessed in terms of discrimination and calibration. Besides, we compared the model with EuroSCORE-2 in terms of discrimination and calibration.Results: Postoperative death occurred in 26 (7.6%) out of 342 patients in the training cohort, and in 10 (6.8%) out of 147 patients in the validation cohort. Eight preoperative factors were associated with postoperative death, including age, critical state, recent myocardial infarction, stroke, left ventricular ejection fraction (LVEF) ≤35%, LV dilatation, increased serum creatinine, and combined surgery. The nomogram achieved good discrimination with C-indexes of 0.889 (95%CI, 0.839–0.938) and 0.899 (95%CI, 0.835–0.963) in predicting the risk of mortality after CABG in the training and validation cohorts, respectively, and showed well-fitted calibration curves in the patients whose predicted mortality probabilities were below 40%. Compared with EuroSCORE-2, the nomogram had significantly higher C-indexes in the training cohort (0.889 vs. 0.762, p = 0.005) as well as the validation cohort (0.899 vs. 0.816, p = 0.039). Besides, the nomogram had better calibration and reclassification than EuroSCORE-2 both in the training and validation cohort. The EuroSCORE-2 underestimated postoperative mortality risk, especially in high-risk patients.Conclusions: The nomogram provides an optimal preoperative estimation of mortality risk after CABG in patients with HFrEF and has the potential to facilitate identifying HFrEF patients at high risk of in-hospital mortality.
Synergetic Effect of Combined CaO2 and Microwave Treatment on Waste Active Sludge Dewaterability and Organic Contaminants’ Removal
Authors: Wang Jie , Shang Kankan , Da Liangjun , Liu Xingguo , Zhao Yongjing , Zhang Ai 
Published: September 2021

This study investigated the synergetic effect of the combined calcium peroxide (CaO2) and microwave (MW) treatment on waste active sludge dewatering properties and organic contaminants’ removal. The optimal sludge dewaterability was obtained at CaO2 (20 mg/gVSS)/MW (70°C), and the capillary suction time decreased by 52% compared with raw sludge. Further investigation indicated that total extracellular polymeric substances (EPS), tightly bound EPS, total protein, and protein present in tightly bound EPS were closely correlated with sludge dewaterability. Tryptophan, aromatic protein–like substances and humic acid–like substances were the key compounds that affect sludge dewaterability. The charge neutralization and bridge effect of cation ions were strengthened when combined with MW irradiation. In addition, it was revealed that MW facilitated CaO2 to produce more hydroxyl and superoxide anion radicals. This study confirmed CaO2/MW to be an effective way to improve sludge dewatering and remove organic pollutants from sludge.
CircC6orf132 Facilitates Proliferation, Migration, Invasion, and Glycolysis of Gastric Cancer Cells Under Hypoxia by Acting on the miR-873-5p/PRKAA1 Axis
Authors: Chen Weizhi , Ji Yanhong 
Published: September 2021

Background: Hypoxia is a crucial factor in the progression of various tumors, including gastric cancer (GC). Circular RNAs (circRNAs) are important regulators in GC, and this study focused on researching circC6orf132 in GC progression under hypoxia.Methods:In vitro experiments were performed in GC cells under hypoxia (1% O2). CircC6orf132, microRNA-873-5p (miR-873-5p), and protein kinase AMP-activated alpha 1 catalytic subunit (PRKAA1) levels were examined by real-time polymerase chain reaction (qRT-PCR). Colony formation assay and transwell assay were used for detecting cell proliferation and migration or invasion. Glycolytic metabolism was evaluated using lactate production, glucose uptake, and adenosine triphosphate (ATP) level and extracellular acidification rate (ECAR). Western blotting was performed for determining protein expression. The target interaction was analyzed by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. In vivo assay was conducted via mouse xenograft model.Results: The expression of circC6orf132 was significantly high in GC cells under hypoxia. Hypoxia-induced GC proliferation, migration, invasion, and glycolysis were reversed by silencing circC6orf132. CircC6orf132 targeted miR-873-5p; and the inhibition of circC6orf132 knockdown for the effects of hypoxia on GC cells was abrogated by miR-873-5p inhibitor. PRKAA1 was validated as a downstream gene of miR-873-5p, and miR-873-5p functioned as an anticancer molecule in GC cells under hypoxia by downregulating PRKAA1 level. CircC6orf132 could regulate PRKAA1 by sponging miR-873-5p. CircC6orf132/miR-873-5p/PRKAA1 axis could regulate GC progression under the hypoxic condition. CircC6orf132 downregulation reduced tumorigenesis in vivo through affecting the miR-873-5p/PRKAA1 axis.Conclusion: CircC6orf132 has been affirmed to promote proliferation, migration, invasion, and glycolysis in GC under hypoxia, partly by depending on the regulation of miR-873-5p/PRKAA1 axis.
Apoptotic Cells for Therapeutic Use in Cytokine Storm Associated With Sepsis– A Phase Ib Clinical Trial
Authors: van Heerden Peter Vernon , Abutbul Avraham , Sviri Sigal , Zlotnick Eitan , Nama Ahmad , Zimro Sebastian , el-Amore Raja , Shabat Yehudit , Reicher Barak , Falah Batla , Mevorach Dror 
Published: September 2021

BackgroundSepsis has no proven specific pharmacologic treatment and reported mortality ranges from 30%–45%. The primary aim of this phase IB study was to determine the safety profile of Allocetra™-OTS (early apoptotic cell) infusion in subjects presenting to the emergency room with sepsis. The secondary aims were to measure organ dysfunction, intensive care unit (ICU) and hospital stays, and mortality. Exploratory endpoints included measuring immune modulator agents to elucidate the mechanism of action.MethodsTen patients presenting to the emergency room at the Hadassah Medical Center with sepsis were enrolled in this phase Ib clinical study. Enrolled patients were males and females aged 51–83 years, who had a Sequential Organ Failure Assessment (SOFA) score ≥2 above baseline and were septic due to presumed infection. Allocetra™-OTS was administered as a single dose (day +1) or in two doses of 140×106 cells/kg on (day +1 and +3), following initiation of standard-of-care (SOC) treatment for septic patients. Safety was evaluated by serious adverse events (SAEs) and adverse events (AEs). Organ dysfunction, ICU and hospital stays, and mortality, were compared to historical controls. Immune modulator agents were measured using Luminex® multiplex analysis.ResultsAll 10 patients had mild-to-moderate sepsis with SOFA scores ranging from 2–6 upon entering the study. No SAEs and no related AEs were reported. All 10 study subjects survived, while matched historical controls had a mortality rate of 27%. The study subjects exhibited rapid resolution of organ dysfunction and had significantly shorter ICU stays compared to matched historical controls (p&lt;0.0001). All patients had both elevated pro- and anti-inflammatory cytokines, chemokines, and additional immune modulators that gradually decreased following treatment.ConclusionAdministration of apoptotic cells to patients with mild-to-moderate sepsis was safe and had a significant immuno-modulating effect, leading to early resolution of the cytokine storm.Clinical Trial RegistrationClinicalTrials.gov Identifier: NCT03925857. (https://clinicaltrials.gov/ct2/show/study/NCT03925857).
Hypoxia-Related lncRNA Correlates With Prognosis and Immune Microenvironment in Lower-Grade Glioma
Authors: Xu Shengchao , Tang Lu , Liu Zhixiong , Luo Chengke , Cheng Quan 
Published: September 2021

BackgroundHypoxia-related genes are demonstrated to correlate with the prognosis of various cancers. However, the role of hypoxia-related long non-coding RNAs (HRLs) in lower-grade glioma (LGG) remains unclear.MethodsA total of 700 LGG samples were extracted from TCGA and CGGA databases. Pearson correlation analysis was used to identify HRLs. Lasso analysis was adopted to construct the HRL signature. TIDE algorithm was used to predict responses to immune checkpoint inhibitors. Cell proliferation was estimated by cell counting kit-8 assay, colony formation assay, and EdU assay.ResultsWe identified 340 HRLs and constructed a novel risk signature composed of 19 HRLs. The risk score exhibited potent value in predicting the prognosis of LGG patients and was significantly associated with the prognosis of LGG patients. Moreover, HRL signature could distinguish patients with similar expression levels of immune checkpoints and might predict the efficacy of immune checkpoint inhibitors. Additionally, hypoxia-related pathways and immune pathways were enriched in high-risk group, and high risk score indicated low tumor purity and high immune infiltration. Two major HRLs, LINC00941 and BASP1-AS1, could significantly affect the proliferation of glioma cells.ConclusionsOur study constructed a novel HRL signature that could predict the prognosis and immunotherapy response of LGG patients. HRLs could be novel biomarkers to predict the prognosis of LGG patients and potential targets for LGG treatment.
Ultra-Thin Metasurface-Based Absorber of Low-Frequency Sound With Bandwidth Optimization
Authors: Guan Yi-jun , Ge Yong , Sun Hong-xiang , Yuan Shou-qi , Lai Yun , Liu Xiao-jun 
Published: September 2021

We report, both theoretically and experimentally, a type of ultra-thin metasurface-based low-frequency sound absorber with bandwidth optimization. Such a metasurface unit consists of an ultrathin resonator (thickness∼1/90 wavelength) with a circular hole on the upper panel and four narrow slits inside a multiple-cavity structure. Eigenmode simulations of the unit show rich artificial Mie resonances, in which a type of monopolar Mie resonance mode can be obtained at 238.4 Hz. Based on the excitation of the monopolar mode, we can realize the near-perfect low-frequency sound absorption with the maximum absorption coefficient and fractional bandwidth of 0.97 and 12.9%, respectively, which mainly arises from the high thermal-viscous loss around the circular hole and four narrow slits of the unit. More interestingly, by combining 4 units with different diameters of the circular hole, we further enhance the fractional bandwidth of the compound unit to 18.7%. Our work provides a route to design ultra-thin broadband sound absorbers by artificial Mie resonances, showing great potential in practical applications of low-frequency noise control and architectural acoustics.
Ab-Initio Predictions of the Energy Harvesting Performance of L-Arginine and L-Valine Single Crystals
Authors: Guerin Sarah 
Published: September 2021

Biological piezoelectric materials are beginning to gain attention for their huge potential as eco-friendly energy harvesting materials. In particular, simple amino acid and peptide crystal assemblies are demonstrating large voltage outputs under applied force, and high sensitivity when detecting vibrations. Here we utilise Density Functional Theory (DFT) calculations to quantitatively predict the energy harvesting properties of two understudied proteinogenic amino acid crystals: L-Arginine and L-Valine. The work highlights the ability of quantum mechanical calculations to screen crystals as high-performance energy harvesters, and demonstrates the capability of small biological crystals as eco-friendly piezoelectric materials. L-Arginine is predicted to have a maximum piezoelectric voltage constant of gij= 274 mV m/N, with a Young’s Modulus of E = 17.1 GPa. L-Valine has a maximum predicted piezoelectric voltage constant of gij= 62 mV m/N, with a calculated Young’s Modulus of E = 19.8 GPa.
The Performance Index Identifies Changes Across the Dual Task Timed Up and Go Test Phases and Impacts Task-Cost Estimation in the Oldest-Old
Authors: Brauner Fabiane Oliveira , Balbinot Gustavo , Figueiredo Anelise Ineu , Hausen Daiane Oliveira , Schiavo Aniuska , Mestriner Régis Gemerasca 
Published: September 2021

Introduction: Dual tasking is common in activities of daily living (ADLs) and the ability to perform them usually declines with age. While cognitive aspects influence dual task (DT) performance, most DT-cost (DT-C) related metrics include only time- or speed- delta without weighting the accuracy of cognitive replies involved in the task.Objectives: The primary study goal was to weight the accuracy of cognitive replies as a contributing factor when estimating DT-C using a new index of DT-C that considers the accuracy of cognitive replies (P-index) in the instrumented timed up and go test (iTUG). Secondarily, to correlate the novel P-index with domains of the Mini-Mental State Examination (MMSE).Methods: Sixty-three participants (≥85 years old) took part in this study. The single task (ST) and DT iTUG tests were performed in a semi-random order. Both the time taken to complete the task measured utilizing an inertial measurement unit (IMU), and the accuracy of the cognitive replies were used to create the novel P-index. Clinical and sociodemographic data were collected.Results: The accuracy of the cognitive replies changed across the iTUG phases, particularly between the walk 1 and walk 2 phases. Moreover, weighting 0.6 for delta-time (W1) and 0.4 for cognitive replies (W2) into the P-index enhanced the prediction of the MMSE score. The novel P-index was able to explain 37% of the scores obtained by the fallers in the “spatial orientation” and “attention” domains of the MMSE. The ability of the P-index to predict MMSE scores was not significantly influenced by age, schooling, and number of medicines in use. The Bland-Altman analysis indicated a substantial difference between the time-delta-based DT-C and P-index methods, which was within the limits of agreement.Conclusions: The P-index incorporates the accuracy of cognitive replies when calculating the DT-C and better reflects the variance of the MMSE in comparison with the traditional time- or speed-delta approaches, thus providing an improved method to estimate the DT-C.