bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Value of Prognostic Nutritional index and Systemic Immune‐Inflammation Index on Tumor Progression in Bladder Cancer Patients with After Radical Cystectomy
Authors: zhou jiatong , xu xitong , liu ranlu 
Published: February 2021

Abstract
OBJECTIVES: The purpose of this study was to explore the predictive value of preoperative prognostic nutritional index(PNI) and systemic immune‐inflammation index(SII) for local tumor stage in bladder cancer(BC) after radical cystectomy(RC).METHODS: We researched our database between April 2011 and October 2019. There were 195 BC patients who underwent RC. The PNI and SII were calculated using preoperative blood sample results. The predictive value of SII and PNI was analysed with univariate and multivariate Cox regression models. Significant P was P<0.05.RESULTS: Of patients, all patients were males with a mean age of 67.94±8.97years. Mean serum albumin was 42.13±4.28(g/L), mean PNI score was 51.29±6.09 and mean SII was 661.67±506.22. Multivariable Cox regression analysis demonstrated that PNI scores and SII could not play a significantly predictive factor between muscle invasive bladder cancer(MIBC) and non-muscle-invasive bladder cancer(NMIBC). While we also found PNI was an independent risk factors for predicting tumor stagep(pT＜3a and pT≥3a).CONCLUSIONS: Our research revealed that preoperative low PNI but not SII could be used as an independent factor to predict worse pathologically stage(pT≥3a). We still need future studies with large cohorts to identify our results.
Inorganic and Lead-free CsBi3I10 Thin Film Solar cell Prepared by Single-source Thermal Evaporation
Authors: Lan Huabin , Chen Xingye , Fan Ping , Liang Guangxing 
Published: February 2021

Abstract
All inorganic lead-free halide perovskites have attracted much attention due to their non-toxic and good band gap. In this paper, we first prepared all inorganic lead-free perovskite CsBi3I10 thin films by single source thermal evaporation deposition. The results show that CsBi3I10 thin films prepared by single source thermal evaporation have layered structure, high purity hexagonal phase and high crystallinity, which are consistent with the theoretical calculation results. The surface of the thin film was compact and uniform, and had high homology with the crystal structure of the evaporation source material. After annealing, the crystallinity of the film was further improved. The band gap of the CsBi3I10 thin film calculated was 1.83 eV, Perovskite solar cells based on CsBi3I10 thin films exhibit an efficiency of up to 0.84%. These results indicate that the proposed single source thermal evaporation method has the potential to prepare high efficiency inorganic lead-free perovskite solar cells.
Clinical Implications of CA 125 Elevation in Patients with Cardiac Amyloidosis: An Observational Study
Authors: Li Muzheng , Wu Zhijian , Tudahun Ilyas , Lin Qiuzhen , Liu Na , Liu Jiang , Wang Yingmin , Chen Mingxian , Chen Yaqin , Qi Nenghua , Zhu Qingyi , Li Wei , Tang Jianjun , Liu Qiming 
Published: February 2021

Abstract
Aims: The level of serum carbohydrate antigen 125 (CA 125) elevated is a common finding in patients with cardiac amyloidosis in clinical practice. It is unclear whether CA 125 is correlated with cardiac amyloidosis. The aim of this study was to systematically evaluate the clinical implications of CA 125 elevation in patients with cardiac amyloidosis.Methods and Results: We enrolled 101 patients diagnosed with cardiac amyloidosis at the Second Xiangya Hospital, 41 patients with acute decompensated heart failure (AHF) and 39 patients with multiple myeloma (MM) who were confirmed to have no cardiac amyloidosis served as control group, respectively. In 101 patients with cardiac amyloidosis, 58 (57%) patients had elevated serum CA 125 levels, which the mean age was 61.2 ± 11.4 years. Patients with high CA 125 were more likely to present with polyserositis ( 79.3% vs 60.5%, p = 0.03) , higher levels of hemoglobin (117.22 ± 21.87 g/L vs. 106.07 ± 25.15 g/L, p = 0.01), serum potassium (4.17 ± 0.49 mmol/L vs. 3.98 ± 0.41 mmol/L, p = 0.05), low density lipoprotein-cholesterol (2.98 ± 1.65 mmol/L vs. 2.22 ± 1.10 mmol/L, p = 0.01), and cardiac troponin T (115 pg/mL vs. 59.52 pg/mL, p = 0.005) . The serum CA 125 levels were significantly higher in cardiac amyloidosis than AHF and MM. The median overall survival for patients with elevated and normal serum CA125 were 5 and 20 months, respectively (p = 0.012). According to multivariate Cox hazard analysis, CA 125 (HR 1.002, 95%CI 1.000-1.004, p = 0.020) contributed to all-cause mortality. The time-dependent receiver operating characteristic was used to reflect the accuracy of different biomarkers in predicting overall survival at various time points by the area under the curve (AUC). CA 125 has no worse prediction accuracy than cardiac troponin T, NT-proBNP and LDH according to the AUC.Conclusions: The prevalence of elevated serum CA 125 levels is more than 50% in patients with cardiac amyloidosis. As an independent prognostic predictor, highly serum CA 125 values indicated the lower overall survival and the accuracy of predicting prognosis was not inferior to the other biomarkers.
Novel method using DW-MRI and ADC images to guide stereotactic biopsy for the diagnosis small primary angiitis of the central nervous system: A case report
Authors: Su Xu , Han Liang , Li Mengxing , Wang Zhengming , Gao Jiadui , Tian Yu , Du Chao 
Published: February 2021

Abstract
Objective

To determine the role of diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) imaging to guide stereotactic biopsy for the diagnosis of intracranial angiitis.
Case presentation

In a 28-year-old woman who had experienced inactive headache and right limbs numbness for 4 days, preoperative magnetic resonance (MR) scanning, enhanced scanning, diffusion tensor imaging, magnetic resonance spectroscopy, diffusion-weighted imaging (DWI), and ADC image scanning were performed. Stereotactic biopsy was performed in one target where the area of edema detected with MR FLAIR, and two targets where the area shown as a high-value and a lower-value area in the DWI/ ADC image. Pathological examinations together with computed tomographic and enhanced MRI scans were conducted after surgery. A preoperative enhanced MRI scan showed a uniform low-intensity lesion in the patient’s left centrum semiovale, with a volume of 3.1 cm3. The DWI and ADC images showed uneven high-intensity signals and different ADC values in the lesion area, respectively. During surgery, tissues around the lesion and the lesion center were sampled at the three selected targets. The postoperative pathological diagnosis was primary angiitis of the central nervous system, and the patient was given anti-inflammatory medication and hormone therapy. The 3-year follow-up confirmed that the patient had recovered well, with a Glasgow Outcome Scale score of 5.
Conclusion

DW-MRI and ADC images can be reliably used to determine the location of small intracranial lesions, and guide stereotactic biopsy to facilitate the diagnosis of primary vasculitis of the central nervous system.
NUT Midline Carcinoma as a Primary Lung Tumor Treated With Anlotinib Combined With Palliative Radiotherapy: a Case Report
Authors: Jiang Jin , Ren Yikun , Xu Chengping , Lin Xing 
Published: February 2021

Abstract
Background: NUT (nuclear protein in testis) midline carcinoma (NMC) is a rapidly progressive tumor arising from midline structures. Recent cases have reported that the poor prognosis with a median survival of 6.7 months and a 2 years overall survival of 19% due to limited treatment. Based on the effect of arotinib on inhibiting tumor growth and angiogenesis. We present one patient case treated with anlotinib and radiotherapy.Case presentation: Here, we describe a 33-year old patient who complained of cough and chest pain and was diagnosed as a pulmonary NMC through CT scan, FISH and immunohistochemistry. In addition, we initially demonstrated that anlotinib combined with palliative radiotherapy could significantly prevent the tumor growth in a pulmonary NMC.Conclusion: The report indicated that anlotinib combined with palliative radiotherapy could inhibit the tumor progression in a pulmonary NMC, which may provide a combined therapy to pulmonary NMC in the future.
Cloning and expressions of chop in loach (Misgurnus anguillicaudatus) and its response to hydrogen peroxide (H2O2) stress
Authors: Li Hui , Kang Minxin , Sun Shouxiang , Gao Jian , Jia Zhiying , Cao Xiaojuan 
Published: February 2021

Abstract
C/EBP [CCAAT/enhancer-binding protein]-homologous protein gene (chop) which plays an important role in endoplasmic reticulum stress-induced apoptosis, was investigated here by RACE and qPCR in an aquaculture animal for the first time. The full-length cDNA sequences of loach (Misgurnus anguillicaudatus) chop were 2533bp, encoding 266 amino acids. chop revealed obvious changes in transcriptions during different early life stages of the loach, and the highest appeared at the 8-cell stage. Among different tissues, loach chop predominantly expressed in gill, spleen and gonad. Then, we performed a hydrogen peroxide (H2O2, a common-used disinfectant) stress trial to explore the role of loach chop, and three different concentrations (0 µM, 50 µM and 100 µM) of H2O2 were set. After the stress, half of the loaches from 100 µM group were dead, whereas all loaches from the other two groups were alive. Meanwhile, the activities of CAT, SOD and GPX decreased obviously with the extension of stress time and increased H2O2 concentration. The expression levels of gill chop in loaches from 100 µM group were significantly higher than those from the other two groups at the 12th hour to 24th hour. atf4 and bax, two proapoptotic genes, significantly up-regulated in 100 µM group compared with the other two groups at the 18th hour and 24th hour. While the expression profiles of an antiapoptotic gene bcl2 basically presented an opposite trend. These results indicated a close relationship between H2O2 stress and fish apoptosis, and loach chop played an important role in response to the stress.
Genome characterization of Zucchini yellow mosaic virus infecting cucurbits reveals the presence of a new genotype in Trinidad &amp; Tobago in the Caribbean region
Authors: Chinnaraja Chinnadurai , Kollam Mounika , Ramsubhag Adesh , Jayaraj Jayaraman 
Published: February 2021

Abstract
Zucchini yellow mosaic virus is a potyvirus, which is becoming a serious pathogen of pumpkin and other cucurbits in Trinidad and Tobago and the entire Caribbean region. In this study, four Zucchini yellow mosaic virus (ZYMV) isolates infecting pumpkin in Trinidad and Tobago were characterized by complete genome sequencing for the first time. Phylogenetic analyses of the isolates showed variability of 5.9–6.0 % nt and 7.7–7.9 % aa sequences with the most closely related isolates NAT and AG (Israel) and SE04T (Slovakia). Based on the variations in complete genome as well as gene sequences, a new genotype designated ZYMV-Trini is proposed for these isolates. Among the gene sequences of ZYMV-Trini isolates, maximum variations were noticed in HC-Pro gene with 20.8 % aa sequence divergence from their closest relatives whereas the least variations were with the NIb, P3 and CP genes (1.8 to 2.2 % aa divergence). This study also proved that transmission of ZYMV can also occur through seeds (2 %), but this was less common than transmission via the aphid species Aphis gossypii. The progression of ZYMV in pumpkin seedlings was quantified by RT-qPCR which showed a rapid surge in viral load after 37 days. From the recombination analyses, it could be concluded that isolates SE04T from Slovakia, NAT from Israel and AG from Israel have major contributions in the genome architecture of ZYMV-Trini isolates.
Development of novel hybrid machine learning models for monthly thunderstorm frequency prediction over Bangladesh
Authors: Azad Md. Abul Kalam , Islam A R M Towfiqul , Rahman Md. Siddiqur , Ayen Kurratul 
Published: February 2021

Abstract
Accurate thunderstorm frequency (TSF) prediction is of great significance under climate extremes for reducing potential damages. However, TSF prediction has received little attention because a thunderstorm event is a combination of intricate and unique weather scenarios with high instability, making it difficult to predict. To close this gap, we proposed a novel hybrid machine learning model through hybridization of data pre-processing Ensemble Empirical Mode Decomposition (EEMD) with two state-of-arts models namely artificial neural network (EEMD-ANN), support vector machine (EEMD-SVM) for TSF prediction at three categories of yearly frequencies over Bangladesh. We were demarcated the yearly TSF datasets into three categories for the period 1981–2016 recorded at 28 sites; high (March-June), moderate (July-October), and low (November-February) TSF months. The performance of the proposed EEMD-ANN and EEMD-SVM hybrid models was compared with classical ANN, SVM, Autoregressive Integrated Moving Average (ARIMA). EEMD-ANN and EEMD-SVM hybrid models showed 8.02%-22.48% higher performance precision in terms of root mean square error (RMSE) compared to other models at high, moderate and low-frequency categories. Eleven out of 21 input parameters were selected based on the Random Forest (RF) variable importance analysis. The sensitivity analysis results showed that each input parameter was positively contributed to building the best model of each category and thunderstorm days are the most contributing parameters influencing TSF prediction. The proposed hybrid models outperformed the conventional models where EEMD-ANN is the most skillful for high TSF prediction, and EEMD-SVM is for moderate and low TSF prediction. The findings indicate the potential of hybridization of EEMD with the conventional models for improving prediction precision. The hybrid model developed in this work can be adopted for TSF prediction in Bangladesh as well as different parts of the world.
The Lucernic Behaviour of Gravity
Authors: Rodrigues Ednardo Moreira 
Published: February 2021

Abstract
In this work it is proposed a scientific line of reasoning called Lucernics which aims to describe natural phenomena in terms of properties of light. It also carries out an analysis about how gravity could be intermediated by virtual particles similar to photons, namely guardions. It also proposes that massive bodies are sinks of guardions. When a massive body absorbs guardions from vacuum fluctuations, dark guardions are emitted. A dark guardion is a virtual particle which carries momentum in a direction opposite to its displacement. The time-derivative of this momentum describes a possible attractive force between massive particles which emit them. This derived force was compared to Newtonian gravitational force and the caliber constant obtained was equal to Planck's mass. This same study was done for electrostatic force, obtaining Planck's charge as a caliber constant. Newton's gravitational constant and Einstein's field equation were decomposed, and it also proposes a Lucernic Field Equation. The phenomena that this equation could describe will be discussed in future works.
Security-enrichment of an asymmetric optical image encryption-based devil’s vortex Fresnel lens phase mask and lower upper decomposition with partial pivoting in gyrator transform domain
Authors: - Anshula , Singh Hukum 
Published: February 2021

Abstract
An asymmetric optical cryptosystem to encrypt images using devil’s vortex Fresnel lens (DVFLs) phase masks and lower upper decomposition with partial pivoting (LUDPP) is proposed in gyrator transform domain. The proposed cryptosystem utilizes DVFLs which are the complex phase masks designed using the combination of a phases of devil’s lens (DL), vortex lens(VL), and Fresnel lens (FL). LUDPP is an operation used to decompose the matrix and is utilized to supersede the phase-truncation (PT) task in the traditional phase-truncated Fourier transform (PTFT). Hence, the proposed method is immune to the attacks to which the PTFT-based cryptosystems are vulnerable. The cryptosystem is asymmetric as both the encryption and decryption processes are different along with different keys. The private keys generated during the encryption process are utilised in the decryption process to retrieve the original image. The encryption and decryption process can be realised with both the digital and the modified optical architecture. In order to show the strength and robustness of the proposed encryption, a conspire numerical simulation was performed.
Influence of H. Pylori and Sex on Leukocyte Differentials
Authors: Fukui Yuri , Yamanaka Hiroyuki , Kitamura Noboru , Takei Masami , Iwamoto Maho , Moriyama Mitsuhiko , Kato Kimitoshi , Maejima Mamoru , Shirinskaya Natalia , Matsukawa Yoshihiro 
Published: February 2021

Abstract
Background: Influence of Helicobacter pylori infection and sex difference on leukocyte differentials was insufficiently understood. We therefore conducted the current study to evaluate influence of H. pylori and sex on peripheral leukocyte differentials as well as influence of Helicobacter pylori eradication. Methods: Dyspeptic patients and persons asked to examine gastroduodenal lesions at medical check were included. Total leukocytes, differentials, and anti-H.pylori IgG antibody were measured. Those change after eradication was also measured. H. pylori infection was assessed by anti-H. pylori IgG antibody, rapid urease test, and pathologic findings. H. pylori-uninfected patients and non-dyspeptic/seronegative persons were regarded as negative controls. Results: Totally 374 patients and 299 controls were evaluated, and 167 patients were successfully eradicated. Peripheral counts of neutrophil and monocyte elevated with H. pylori infection: 3221.7+/-1108.7 vs. 2911.9+/-1027.3/μL and 307.5+/-130.5 vs. 281.5+/-106.4/μL, (p­=.0002 and .0054). Compared to females, males manifested elevated counts of every leukocyte, but the difference was insignificant in basophil (p=.0089, 0.0316, <.0001, and .0384 for neutrophil, lymphocyte, monocyte, and eosinophil, respectively). After eradication, counts of neutrophil, lymphocyte, and monocyte declined: 3111.0+/-966.8 to 2785.1+/997.2/μL, 1905.9+/-603.2 to 1831.6+/-613.5/μL, and 293.1+/-113.3 to 264.3+/-93.6/μL by 2 months (p=<.0001, .0189, and .0004). In contrast, eosinophil counts elevated from 123.2+/-97.0 to 139.8+/-115.4 by 2 months, and to 159.6+/-132.8/μL by 6 months (p=.0349 and <.0001). Conclusions: We confirmed increases in neutrophils and monocytes in H. pylori-infected patients. Successful eradication reduced peripheral counts of neutrophil, lymphocyte, and monocyte, whereas it increased eosinophil counts. Males manifested elevated counts of every leukocyte, comparing to females. H. pylori infection influences systemic immune response and may not predispose to allergic disorders.Trial registration: The study protocol was registered on UMIN (University hospital Medical Information Network system) in Japan (R000017345) in 2014.
SARS-CoV-2 European resurgence foretold: interplay of introductions and persistence by leveraging genomic and mobility data
Authors: Lemey Philippe , Ruktanonchai Nick , Hong Samuel , Colizza Vittoria , Poletto Chiara , Broeck Frederik Van den , Gill Mandev , Ji Xiang , Levasseur Anthony , Sadilek Adam , Lai Shengjie , Tatem Andrew , Baele Guy , Suchard Marc , Dellicour Simon 
Published: February 2021

Abstract
Following the first wave of SARS-CoV-2 infections in spring 2020, Europe experienced a resurgence of the virus starting late summer that was deadlier and more difficult to contain. Relaxed intervention measures and summer travel have been implicated as drivers of the second wave. Here, we build a phylogeographic model to evaluate how newly introduced lineages, as opposed to the rekindling of persistent lineages, contributed to the COVID-19 resurgence in Europe. We inform this model using genomic, mobility and epidemiological data from 10 West European countries and estimate that in many countries more than 50% of the lineages circulating in late summer resulted from new introductions since June 15th. The success in onwards transmission of these lineages is predicted by SARS-CoV-2 incidence during this period. Relatively early introductions from Spain into the United Kingdom contributed to the successful spread of the 20A.EU1/B.1.177 variant. The pervasive spread of variants that have not been associated with an advantage in transmissibility highlights the threat of novel variants of concern that emerged more recently and have been disseminated by holiday travel. Our findings indicate that more effective and coordinated measures are required to contain spread through cross-border travel.
Cerebrovascular risk factors are the predictive factor for ischemic cerebrovascular diseases in patients with Philadelphia chromosome (Ph)–negative myeloproliferative neoplasms: a case control study
Authors: Wen Shirong , Zhang Wenxiao , Fei Yiping , Guan Ke , Zhao Hui , Song Peng , Ye Xiangmei , Cao Fenglin , Zhou Jin , Pan Yujun 
Published: February 2021

Abstract
Background: The ischemic cerebrovascular disease (ICVD) is major thrombotic complication of Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (Ph-negative MPNs) which included essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) leading to high disability and mortality rates. However, risk factors attributable to ICVD in Ph-negative MPNs patients are still not understood. This study aimed to identify risk factors for ICVD in Ph-negative MPNs. Methods: Patients with Ph-negative MPNs were divided into ICVD and non-ICVD groups. The demographic, biochemical, genetic parameters (JAK2V617F and CALR mutations) were assessed. The association between these factors and ICVD was assessed using logistic regression analysis.Results: One hundred eighty five Ph-negative MPNs patients (82 ET, 78 PV, and 25 PMF) were recruited，and 57 (30.8%) had ICVD which was higher than recently published data. The higher prevalence of hypertension(59.6% vs 32.0%), smoking(22.8% vs 6.3%), drinking(22.8% vs 6.3%), JAK2V617F mutation(78.9% vs 63.3%), the percentage of neutrophils( 78.76% vs 71.73%)， the lower prevalence of CALR mutation(3.2% vs 22.2%) and the percentage of basophils(0.82% vs 1.40%) were found in the ICVD group comparing with the non-ICVD group. The frequency of ICVD events was significantly higher in patients with JAK2V617F mutation than in those without (35.7% and 20.3%, P=0.034). Multivariate logistic regression analysis showed that hypertension (OR=2.464, 95%CI 1.218-4.983, p=0.012) and smoking (OR=5.426, 95%CI 1.919-15.340, p=0.001) were significantly positively associated with ICVD events. For ET patients, both smoking (OR=4.414, 95%CI 1.079-15.685, p=0.038) and increased percentage of neutrophils (OR=1.080, 95%CI 1.019-1.144, p=0.009) were independently associated with ICVD incidence. Hypertension (OR=4.647, 95%CI 1.215-17.781, p=0.025), smoking (OR=6.065, 95%CI 1.083-33.951, p=0.040), and increased percentage of lymphocytes (OR=1.039, 95%CI 1.002-1.078, p=0.039) were all positively correlated with ICVD risk in PV patients. Conclusions: Our data suggest that hypertension, smoking, higher percentage of neutrophils and lymphocytes rather than JAK2V617F and CALR mutations may be associated with an elevated risk of ICVD in Ph-negative MPNs patients, although the relative role of each factor may vary in the individual subgroup. Additional studies of large patient cohorts will be essential to validate these findings.