bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involuntary narratives of decreasing anxiety in breast cancer patients: Study in Ukraine
Authors: Orap Maryna O. 
Published: August 2021

AbstractBackgroundThe main purpose of our study was to theoretically substantiate and practically verify the effectiveness of the developed method of reducing anxiety in breast cancer patients.MethodWe suggest that involuntary narratives, such as spontaneous, unprepared and non‐structural writing without rumination, help to express fears and concerns, thoughts and emotions and, as a result, decrease the level of anxiety. The respondents (49 female patients diagnosed with breast cancer at the Oncology Center of Ternopil, Ukraine, mean age 55.43 ± 11.31 years) were asked to write down (for 10 days) all their emotions and thoughts, which appeared in the morning immediately after awakening. They were asked to provide spontaneous thoughts without proper grammar, not observing lexical or spelling rules.ResultsComparison of the level of state anxiety and differential emotions in the experimental and control groups before and after the experiment showed a statistically significant decrease in the level of anxiety and negative emotions in breast cancer patients.ConclusionsThe primary practical application of the study is the prospect of using involuntary narratives to decrease anxiety in breast cancer patients.
Essential Oil Composition of Five Thymus Species from Bulgaria
Authors: Trendafilova Antoaneta , Todorova Milka , Ivanova Victoria , Zhelev Petar , Aneva Ina 
Published: August 2021

AbstractIn this study, the essential oil composition of five Thymus species, belonging to Sect. Hyphodromi (A. Kerner) Halácsy – Thymus atticus Čelak., T. leucotrichus Halácsy, T. striatus Vahl, T. zygioides Griseb. and T. perinicus (Velen.) Jalas. was studied by GC/MS/FID. T. atticus, T. leucotrichus, and T. striatus were characterized by high amounts of sesquiterpenoids (57.7, 78.9 and 79.7 %, respectively) with β‐caryophyllene and caryophyllene oxide as the main constituents. Aromatic compounds (61.2 %) were the most abundant group in T. zygioides essential oil, with thymol (51.2 %) as the principal component. The essential oil from the endemic species T. perinicus contained almost equal amounts of monoterpenoids (37.8 %) and aromatic compounds (36.0 %) with borneol (17.9 %) and thymol (20.9 %) as the major components. The obtained results revealed the existence of new chemotypes of T. atticus (caryophyllene oxide/β‐caryophyllene), T. leucotrichus (β‐caryophyllene/elemol/germacrene D) and T. striatus (β‐caryophyllene/germacrene D/caryophyllene oxide). The essential oil content of endemic T. perinicus is reported for the first time. Principal component analysis (PCA) and cluster analysis (CA) were used to investigate the variations in the essential oils of different Thymus species from Sect. Hyphodromi (A. Kerner) Halácsy.
Chemophenetics as a Tool for Distinguishing Morphotypes of Annona emarginata (Schltdl.) H. Rainer
Authors: Ovile Mimi Carolina , De‐la‐Cruz‐Chacón Iván , Caixeta Sousa Marília , Aparecida Ribeiro Vieira Maria , Ortiz Mayo Marques Marcia , Ferreira Gisela , Silvia Fernandes Boaro Carmen 
Published: August 2021

AbstractAnnona emarginata (Annonaceae) has two morphological variations (A. emarginata ‘mirim’ and A. emarginata ‘terra‐fria’). The species has agricultural value and produces specialized metabolites of pharmacological interest. The objective of this work was to analyze whether chemical and morphological differences contribute to differentiate A. emarginata ‘terra‐fria’ from A. emarginata ‘mirim’, as chemophenetic variations of A. emarginata. The analysis of chemical compounds was based on the quantification, profile of root alkaloids and on the leaves volatile profile, together with morphometric analyses of the leaf blade. The samples were collected in three phenological stages (flowering, fruiting, and vegetative) at two places in São Paulo, Brazil. Differences in the composition of the alkaloid profile and leaf volatiles (in both places and in the three phenological stages) allowed us to separate the two morphotypes by multivariate statistical analysis. These differences agreed with the leaf blade morphology and flower color. This first chemophenetic report of A. emarginata demonstrates that, in addition to morphological variations, the specialized metabolism of roots and leaves can be phytochemical characters, which suggest the existence of at least morphochemotypes of A. emarginata.
Polymorphic Phosphorescence from Separable Aggregates with Unique Photophysical Properties
Authors: Pinter Piermaria , Hennersdorf Felix , Weigand Jan J. , Strassner Thomas 
Published: August 2021

AbstractPlatinum complexes aggregate into polymorphs with different intermolecular interactions leading to different photophysical properties. Strong intermolecular interactions stabilize the aggregate to such an extent that the polymorphs can be separated directly by column chromatography. Solid‐state structures as well as quantum‐chemical calculations confirmed the effect of the interactions on the photophysical properties.
Multi‐enzymatic recovery of fungal cellulases (Aspergillus niger) through solid‐state fermentation of sugarcane bagasse
Authors: Alves Tales P. , Triques Carina C. , da Silva Edson A. , Fagundes‐Klen Marcia R. , Hasan Salah D. M. 
Published: August 2021

AbstractIn this study, the optimum conditions for the multi‐enzymatic recovery of cellulases produced by Aspergillus niger were investigated using sugarcane bagasse. Two extraction methods were investigated: the two‐stage solid–liquid extraction (SLE) followed by ultrasound‐assisted extraction (UAE), and the single‐stage SLE. The ultrasound effects were evaluated using a Doehlert design, in which the pH (5.0–9.0) and sonication power (0.8–2.0 W ml−1) were independent variables. For the single‐stage SLE, temperature (25–45°C), time (10–60 min), and pH (5.0–9.0) were analyzed using the Box–Behnken design. Both processes were monitored to evaluate FPase, CMCase, and β‐glucosidase (U ml−1) activities. The maximum enzymatic activities (EA) obtained for FPase, CMCase, and β‐glucosidase in the SLE–UAE were 0.352, 0.321, and 1.412 U ml−1, respectively. Unlike in most previous studies, sonication was insignificant (p < 0.05) with respect to the enzymatic complex within the evaluated ranges. Moreover, sonication changed the EA when lower than 1.2 and higher than 1.6 W ml−1, mainly inhibiting the EA of β‐glucosidase. The single‐stage SLE was more effective than the two‐stage SLE–UAE, and the maximum EA values for FPase, CMCase, and β‐glucosidase were 0.354, 0.303, and 3.135 U ml−1, respectively. The single‐stage process was better because it consumed less energy, required simpler equipment, and provided higher efficiency in a shorter time. This study will improve diversified enzyme extraction from sugarcane bagasse, reduce enzyme production costs, and enhance bagasse utilization.
Experimental and numerical modal analysis of wall tubes in the coal‐fired boiler or radiant syngas cooler
Authors: Shao Lintao , Guo Wei , Yang Weijuan , Xia Zhiwen , Kuang Jianping , Zhou Zhijun 
Published: August 2021

AbstractThe slag deposited on the wall tubes in the coal‐fired boiler or radiant syngas cooler (RSC) of the entrained flow gasifier could reduce the heat transfer efficiency and degrade the tubes by corrosion. During the operation of the boiler or RSC, the rapping‐off‐ash method is an effective method to remove slag deposits, especially in a high‐pressure environment. The operating parameters of the rapping‐off‐ash method are related to the modal parameters of wall tubes, including the natural frequency, damping ratio, and mode shapes. In this study, modal parameters of wall tubes composed of three single tubes and fins were experimentally determined through the modal test analysis under both empty and water‐filled conditions. The dynamic characteristics of wall tubes were extracted by using the roving hammer‐impact test and the frequency response function (FRF). A numerical simulation based on the finite element method in ABAQUS was conducted to compare with the experimental modal analysis. The first five natural modes ranged from 14 to 154 Hz, and the maximum vibration or torsion locations of wall tubes under the corresponding mode frequencies were investigated. The water inside the wall tubes could reduce the stiffness of the structure and decrease the values of natural frequency.
Extreme rainfall and its impacts in the Brazilian Minas Gerais state in January 2020: Can we blame climate change?
Authors: Dalagnol Ricardo , Gramcianinov Carolina B. , Crespo Natália Machado , Luiz Rafael , Chiquetto Julio Barboza , Marques Márcia T. A. , Neto Giovanni Dolif , de Abreu Rafael C. , Li Sihan , Lott Fraser C. , Anderson Liana O. , Sparrow Sarah 
Published: August 2021

AbstractIn January 2020, an extreme precipitation event occurred over southeast Brazil, with the epicentre in Minas Gerais state. Although extreme rainfall frequently occurs in this region during the wet season, this event led to the death of 56 people, drove thousands of residents into homelessness, and incurred millions of Brazilian Reais (BRL) in financial loss through the cascading effects of flooding and landslides. The main question that arises is: To what extent can we blame climate change? With this question in mind, our aim was to assess the socioeconomic impacts of this event and whether and how much of it can be attributed to human‐induced climate change. Our findings suggest that human‐induced climate change made this event >70% more likely to occur. We estimate that >90,000 people became temporarily homeless, and at least BRL 1.3 billion (USD 240 million) was lost in public and private sectors, of which 41% can be attributed to human‐induced climate change. This assessment brings new insights about the necessity and urgency of taking action on climate change, because it is already effectively impacting our society in the southeast Brazil region. Despite its dreadful impacts on society, an event with this magnitude was assessed to be quite common (return period of 4 years). This calls for immediate improvements on strategic planning focused on mitigation and adaptation. Public management and policies must evolve from the disaster response modus operandi in order to prevent future disasters.
Rectal endometriosis mimicking primary rectal adenocarcinoma
Authors: Hu Jingjing , Hosseini Mojgon , Hasteh Farnaz , Murphy Paul , Pare Christopher , Kwong Wilson T. , Patel Charmi 
Published: August 2021

AbstractEndometriosis is a benign entity defined as the presence of endometrium tissue outside of uterine cavity. It is a common disease involving peritoneum, pelvic organs, gastrointestinal tract, and so on. Diagnosis based on cytology specimen can be challenge when we encounter increased cytological atypia in the glandular epithelium, with abundant inflammatory cells and debris in the background. We presented a case of deep rectal endometriosis mimicking rectal adenocarcinoma on cytology specimen and on MRI imaging studies. The combination of endometrial glands, cellular Mullerian stroma, hemorrhage, and hemosiderin‐laden macrophages are the characteristic features on cytologic specimens.
Fine needle biopsy of pediatric‐type follicular lymphoma—Cytology, flow cytometry and FISH pattern: A case report
Authors: Barroca Helena , Marques Cristina , Soares Maria José , Carvalhais Inês 
Published: August 2021

AbstractPediatric‐type follicular lymphomas are rare lymphomas, affecting mostly children and young adults. These are characterized by an excellent prognosis, despite their conservative therapeutic approach. Recognized as an entity in the most recent 2016 WHO classification of tumors of hematopoietic and lymphoid tissues, its diagnosis is based on the recognition of an exclusively nodular architecture, thus conditioning the possibility of a cytological diagnosis. It is thus not odd, the scant literature found on the cytological approach to these lesions. Herein we describe a case of a pediatric‐type follicular lymphoma, first approached through fine needle biopsy. The case is thoroughly discussed from a cytologic, immunophenotypic, and molecular point of view. Differential diagnoses are discussed. The final diagnosis was performed on histology.
Diagnosis of anaplastic lymphoma kinase‐negative anaplastic large cell lymphoma on pleural fluid cytology
Authors: Greenland Nancy Y. , Lu Chuanyi M. , Cook Stephen , Peng Yue 
Published: August 2021

AbstractALK‐negative anaplastic large cell lymphoma (ALCL) is an aggressive non‐Hodgkin T‐cell lymphoma. Compared to ALK‐positive ALCL, patients with ALK‐negative ALCL typically are older, present with nodal disease, and have lower survival rates. We report a unique presentation of ALK‐negative ALCL in a pleural fluid. Cell block preparation enabled both confirmation of the diagnosis via immunohistochemical staining and gene rearrangement testing for prognostic information.
Methotrexate‐associated proliferative disorder in the lower esophagus extending to the gastroesophageal junction: A case report
Authors: Hojo Yuki , Takatsuna Masafumi , Ikarashi Satoshi , Kamimura Hiroteru , Kimura Rika , Mito Masaki , Watanabe Yusuke , Tani Yusuke , Yokoyama Junji , Terai Shuji 
Published: August 2021

AbstractA 64‐year‐old woman was receiving oral methotrexate (MTX) for rheumatoid arthritis (RA) for 15 years. She underwent esophagogastroduodenoscopy because of discomfort in the chest. Endoscopic findings revealed an ulcer in the lower esophagus extending to the gastroesophageal junction (EGJ). The ulcer occupied half of the esophageal lumen and had a sharp and clear margin. Magnifying narrow‐band imaging endoscopy revealed the deposition of white plaque, and there were few microvessels in the edge and bottom of the ulcer. Histologic examination of the biopsy specimens from the oral edge of the lesion revealed proliferation of atypical lymphoid cells (immunophenotype results: CD20 [+], CD3 [partially +], CD5 [−], and BCL‐2 [−]]. The patient was diagnosed with methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) and was advised to stop MTX intake. After 2 months of stopping MTX, the ulcer was found to be almost regressed and showed signs of healing. MTX‐LPD in the lower esophagus extending to the EGJ is extremely rare. This case can help in expanding the understanding of esophageal MTX‐LPD.
Evaluating evidence‐based interventions in low socio‐economic‐status populations
Authors: Radunz Marcela , Pritchard Luke , Steen Eloisa , Williamson Paul , Wade Tracey D. 
Published: August 2021

AbstractObjectiveSocio‐economic‐status (SES) has rarely been reported or investigated in eating disorders (EDs) research. This Research Forum considers, from various perspectives, how SES may impact on evaluating evidence‐based treatments for EDs.MethodWe first reviewed previous literature that informs how SES impacts prevalence of EDs, help‐seeking, and treatment outcome. We then present findings from a case series effectiveness study of an early intervention program in low SES areas for EDs and discuss implications about the impact of SES on the effectiveness of evidence‐based interventions. Finally, we examine barriers to conducting rigorous evaluations in this population and discuss directions for future treatment outcome research.ResultsEvidence suggests a higher level of disordered eating but less help seeking in lower SES groups. In our case series, 96 participants started treatment and completed a mean of 13.85 sessions, 84 (87.5%) completed a mean of 6.40 sessional measures on ED cognitions and behaviors, but only 31% completed more extensive pre‐treatment and post‐treatment measures. The completer effect size decrease for the global Eating Disorder Examination‐Questionnaire score was 2.05 (95% CI: 1.43, 2.68) commensurate with other effectiveness studies in mixed SES groups. The high rates of missing data related to more extensive assessment present a barrier to evaluating evidence‐based treatments in this population.DiscussionEvidence from the present study revealed individuals from low SES can achieve similar treatment outcomes to other populations when receiving evidence‐based ED treatment. Future studies should investigate a range of approaches to maximizing data collection, including use of shorter sessional measures.
Potential hydrological regime requirements for spawning success of the Chinese sturgeon Acipenser sinensis in its present spawning ground of the Yangtze River
Authors: Chang Tao , Gao Xin , Liu Huanzhang 
Published: August 2021

AbstractReservoir impoundment often alters the hydrological regimes of the river and consequently leads to the extinction of some sensitive species. This study analysed the spawning response of a critically endangered (CR) species, Chinese sturgeon Acipenser sinensis, under the changing hydrological regimes caused by the Three Gorges Reservoir (TGR). Based on our statistic analysis, we inferred that the long duration (>100 days) and large magnitude (>1.8 * 106 m3/s) of high flow pulse in the flood season and low accumulated water temperature in October (<660°C) and November (<540°C) were key hydrological regimes to induce the spawning success of Chinese sturgeon. Such hydrological regimes could not be satisfied after the third phase of the TGR impoundment in 2005, which decreased the suitability of the flow (HSIF) and temperature (HSIT) regimes for the spawning of Chinese sturgeon. However, a significant complementary relationship between high HSIF and low HSIT was found in all years of successful spawning after 2005, but it did not occur in the nonspawning years of 2013, 2015 and 2017, which could be the reason for spawning failure in these years. In the years 2018 and 2019, although the complementary relationship existed, the spawning failure in these 2 years was probably due to few parent fish. Therefore, we suggest that future conservation measures should focus on both optimizing operations of the TGR to ensure suitable hydrological conditions and restocking with adult fish to ensure successful spawning.
Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation
Authors: Fionda Cinzia , Stabile Helena , Molfetta Rosa , Kosta Andrea , Peruzzi Giovanna , Ruggeri Silvia , Zingoni Alessandra , Capuano Cristina , Soriani Alessandra , Paolini Rossella , Gismondi Angela , Cippitelli Marco , Santoni Angela 
Published: August 2021

AbstractRearrangement of the actin cytoskeleton is critical for cytotoxic and immunoregulatory functions as well as migration of natural killer (NK) cells. However, dynamic reorganization of actin is a complex process, which remains largely unknown. Here, we investigated the role of the protein Cereblon (CRBN), an E3 ubiquitin ligase complex co‐receptor and the primary target of the immunomodulatory drugs, in NK cells. We observed that CRBN partially colocalizes with F‐actin in chemokine‐treated NK cells and is recruited to the immunological synapse, thus suggesting a role for this protein in cytoskeleton reorganization. Accordingly, silencing of CRBN in NK cells results in a reduced cytotoxicity that correlates with a defect in conjugate and lytic synapse formation. Moreover, CRBN depletion significantly impairs the ability of NK cells to migrate and reduces the enhancing effect of lenalidomide on NK cell migration. Finally, we provided evidence that CRBN is required for activation of the small GTPase Rac1, a critical mediator of cytoskeleton dynamics. Indeed, in CRBN‐depleted NK cells, chemokine‐mediated or target cell–mediated Rac1 activation is significantly reduced. Altogether our data identify a critical role for CRBN in regulating NK cell functions and suggest that this protein may mediate the stimulatory effect of lenalidomide on NK cells.
Practical One‐Pot Multistep Synthesis of 2H‐1,3‐Benzoxazines Using Copper, Hydrogen Peroxide, and Triethylamine
Authors: Trammell Rachel , Cordova Alexandra , Zhang Shuming , Goswami Sunipa , Murata Richel , Siegler Maxime A. , Garcia‐Bosch Isaac 
Published: August 2021

AbstractIn this article, we describe simple one‐pot syntheses of 2H‐1,3‐benzoxazines from ketones utilizing an imino‐pyridine directing group (R1R2‐C=N−CH2‐Pyr), which promotes a Cu‐directed sp2 hydroxylation using H2O2 as oxidant and followed by an oxidative intramolecular C−O bond formation upon addition of NEt3. This synthetic protocol is utilized in the gram scale synthesis of the 2H‐1,3‐benzoxazine derived from benzophenone. Mechanistic studies reveal that the cyclization occurs via deprotonation of the benzylic position of the directing group to produce a 2‐azallyl anion intermediate, which is oxidized to the corresponding 2‐azaallyl radical before the C−O bond formation event. Understanding of the cyclization mechanism also allowed us to develop reaction conditions that utilize catalytic amounts of Cu.
S‐citalopram imprinted monolithic columns for capillary electrochromatography enantioseparations
Authors: Derazshamshir Ali , Göktürk Ilgım , Yılmaz Fatma , Denizli Adil 
Published: August 2021

AbstractIn this study, the molecular imprinting method was used to separate enantiomeric forms of chiral antidepressant drug, R,S‐citalopram (R,S‐CIT) in aqueous solution by CEC system combining the advantages of capillary electrophoresis (CE) and high‐performance liquid chromatography (HPLC). For that, an amino acid‐based molecularly imprinted monolithic capillary column was designed and used as a stationary phase for selective separation of S‐citalopram (S‐CIT) for the first time. S‐CIT was selectively separated from the aqueous solution containing the other enantiomeric form of R‐CIT, which is the same in size and shape as the template molecule. Morphology of the molecularly imprinted (MIP S‐CIT) and non‐imprinted (NIP S‐CIT) monolithic capillary columns was observed by scanning electron microscopy. Imprinting efficiency of MIP S‐CIT monolithic capillary column used for selective S‐CIT separation was verified by comparing with NIP S‐CIT and calculated imprinting factor (I.F:1.81) proved the high selectivity of the MIP S‐CIT for S‐CIT. Cavities formed for S‐CIT form enabled selective (α = 2.08) separation of the target molecule from the other enantiomeric R‐CIT form. Separation was achieved in a short period of 10 min, with the electrophoretic mobility of 7.68 × 10−6 m2/Vs for R,S‐CIT at pH 7.0 10 mM PB and 50% ACN ratio. The performance of both MIP S‐CIT and NIP S‐CIT columns was estimated by repeating the R,S‐CIT separations with intra‐batch and inter‐batch studies for reproducibility of retention times of R,S‐CITs. Estimated RSD values that are lower than 2% suggest that the monolithic columns separate R,S‐CIT enantiomers without losing separation efficiency.