bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary breast osteosarcoma: A case report and review of the literature
Authors: Omranipour Ramesh , Ensani Fereshteh , Hassanesfahani Maryam 
Published: November 2021

AbstractPrimary breast osteosarcoma (PBOS) is an extremely rare and poor prognostic malignancy that has not a definitive treatment guideline. Here, we presented a successfully treated case of PBOS and provided a comprehensive review of the literature which revealed the divergence of opinions regarding the histogenesis and management of this malignancy
Time course of effects of venlafaxine on migraine and generalized pruritus in a patient with depression
Authors: Miyahara Yu , Funahashi Hideki , Haruta‐Tsukamoto Ayaka , Hidaka Hiroto , Fujimoto Takako , Horinouchi Akira , Nishimori Toshikazu , Ishida Yasushi 
Published: November 2021

AbstractVenlafaxine has potential as a therapeutic option for patients with depressive disorder, migraine, and pruritus unresponsive to antihistamines.
Stevens‐Johnson Syndrome due to COVID‐19 vaccination
Authors: Mansouri Parvin , Chalangari Reza , Martits‐Chalangari Katalin , Mozafari Nikoo 
Published: November 2021

AbstractAs public COVID‐19 vaccination programs are being implemented, it is possible that more rare and serious adverse effects such as Stevens‐Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) may occur.
Digesters as Heat Storage – Energetic Assessment of Flexible Variation of Digester Temperature
Authors: Steiniger Bettina , Hubert Christian , Schaum Christian 
Published: November 2021

AbstractA flexible digester temperature enables holistic storage of surplus heat and minimization of heat deficits on water resource recovery facilities (WRRFs). Heat‐saving potentials, performance as heat storage, and emissions of CO2 are considered in four scenarios with increasing flexibility of digester temperature for a model WRRF with 500 000 PE (population equivalent). In comparison to a digester temperature at 37 °C all year, the scenario with seasonal variation of average digester temperatures between 32.5 and 43.6 °C has the greatest annual heat‐saving potential and increase of stored heat. Further, the ranges of digester temperatures indicate a great performance as heat storage.
From Thioureas to Thioquinolines through Isolated Benzothiazines by Gold Catalysis
Authors: Salvador Daniel , Gimeno M. Concepción 
Published: November 2021

AbstractNew benzothiazine heterocycles have been formed from thiourea derivatives by using different gold catalysts. The catalyst and the conditions were optimised towards the selective synthesis of six‐membered benzothiazine heterocycles, characterised by X‐ray diffraction. Interestingly, these organic compounds evolved under gold catalysis in basic medium to achieve the formation of amino thioquinolines through an unprecedented aromatisation process of the heterocycle. The reaction was also carried out stoichiometrically by reaction with gold complexes to afford thioquinolines coordinated to the gold fragment. Benzothiazine, amino thioquinoline heterocycles and gold‐derived species have a great potential for biological applications.
Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects
Authors: Li Xin , Li Yuan , Xu Bing , Zhang Ping , Wang Yangyang , Wang Zhenyu , Hou Shuguang 
Published: November 2021

AbstractThe aim of this study was to evaluate the pharmacokinetic bioequivalence of a generic budesonide nasal spray and a branded product in healthy Chinese subjects under fasting condition. A single‐center, single‐dose, randomized, open‐label, crossover study was conducted in 32 healthy Chinese subjects under fasting condition. The subjects were administered 256 μg of generic budesonide nasal spray (test drug) or branded budesonide nasal spray (RHINOCORT AQUA, reference drug), respectively. For each period, the subjects were administered with 64 μg of budesonide per spray and 2 sprays for each nostril followed by a washout period of 7 days. Plasma concentration of budesonide was determined by a validated high‐performance liquid chromatography–tandem mass spectrometry method. The pharmacokinetic (PK) parameters were calculated, and the bioequivalence was compared using the noncompartment model with the Phoenix WinNonlin 7.0 program. Results show that the 90% confidence intervals of the test/reference ratios of maximum concentration, area under the plasma concentration–time curve from time 0 to the last measurable concentration, and area under the plasma concentration–time curve from time 0 to infinity for the budesonide concentration were 84.8% to 102.7%, 84.6% to 94.4%, and 85.4% to 95.2%, respectively, all fall within the bioequivalent range of 80% to 125%. The test and reference budesonide nasal sprays were PK bioequivalents in healthy Chinese subjects with comparable PK parameters. No serious adverse events were reported, and the 2 products have a good and similar safety profile.
Bed nucleus of the stria terminalis and amygdala responses to unpredictable threat in children
Authors: Feola Brandee , Melancon Sir Norman T. , Clauss Jacqueline A. , Noall Madison P. , Mgboh Adaora , Flook Elizabeth A. , Benningfield Margaret M. , Blackford Jennifer Urbano 
Published: November 2021

AbstractSubstantial evidence from studies in humans suggests the amygdala is pivotal for anxiety. Findings from animal models and translational studies suggests the bed nucleus of the stria terminalis (BNST) is also critical for anxiety and the anticipation of unpredictable threat in adults. However, it remains unknown whether the BNST is involved in unpredictable threat anticipation in children. Forty‐two 8–10‐year‐olds completed resting‐state functional magnetic resonance imaging (fMRI) scans and an unpredictable threat fMRI task in which they were trained to associate cues with images. Intrinsic connectivity analyses were performed to establish functional BNST and amygdala networks. BNST and amygdala activation to cues and images was tested. Significant findings were followed by task‐based functional connectivity analyses. Children showed evidence for BNST and amygdala intrinsic connectivity that was similar to previous patterns observed in adults. In response to unpredictable cues relative to neutral face cues, children had a significant amygdala response but no response in the BNST. The amygdala, but not the BNST, also showed a significantly greater response to fear face images relative to neutral images. Thus, unpredictable threat activated the amygdala, but not BNST, in children. This finding is contrary to studies showing robust BNST activation to unpredictable threat in adults and may suggest that the BNST's role in threat processing emerges later in development.
Taking a few deep breaths significantly reduces children's physiological arousal in everyday settings: Results of a preregistered video intervention
Authors: Obradović Jelena , Sulik Michael J. , Armstrong‐Carter Emma 
Published: November 2021

AbstractThis preregistered, randomized field experiment tested the effectiveness of a brief deep breathing intervention on children's concurrent physiological arousal in naturalistic settings (N = 342; Mage = 7.48 years; 46% female; 53% Asian, 26% White; 21% other race/ethnicity). The treatment consisted of an animated video that introduced deep breathing as a self‐regulation strategy and scaffolded the child in taking a few slow‐paced breaths, while the control group watched an informational video featuring similar animated images. Respiratory sinus arrhythmia (RSA) and heart rate (HR) were measured while children were sitting still (baseline) and subsequently while watching 1‐min videos. Relative to baseline arousal, RSA increased and HR decreased only in response to the deep‐breathing treatment video. Effects were larger in the second 30‐s epoch of the video, which included most of the deep breathing practice. RSA fully mediated the intervention's effects on HR. By analyzing all children exposed to intervention video regardless of their engagement in the deep breathing practice (intention‐to‐treat design) and by using easily scalable treatment videos, the study identifies an effective and pragmatic approach to reducing children's physiological arousal in everyday, group settings. Implications for advancing applied developmental psychophysiological research are discussed.
Phototropic response features for different systematic groups of mesoplankton under adverse environmental conditions
Authors: Dyomin Victor , Morgalev Yuri , Polovtsev Igor , Davydova Alexandra , Morgalev Sergey , Kirillov Nikolay , Morgaleva Tamara , Olshukov Alexey 
Published: November 2021

AbstractCurrent trends in the application of bioindication methods are related to the use of submersible tools that perform real‐time measurements directly in the studied aquatic environment. The methods based on the registration of changes in the behavioral responses of zooplankton, in particular Crustaceans, which make up the vast majority of the biomass in water areas, seem quite promising. However, the multispecies composition of natural planktonic biocenoses poses the need to consider the potential difference in the sensitivity of organisms to pollutants.This paper describes laboratory studies of the phototropic response of plankton to attracting light. The studies were carried out on a model natural community that in equal amounts includes Daphnia magna, Daphnia pulex, and Cyclops vicinus, as well as on the monoculture groups of these species. The phototropic response was initiated by the attracting light with a wavelength of 532 nm close to the local maximum of the reflection spectrum of chlorella microalgae. Standard potassium bichromate was used as the model pollutant.The largest phototropic response value is registered in the assemblage. The concentration growth rate of crustaceans in the illuminated volume was 4.5 ± 0.3 ind (L min)−1. Of the studied species, the phototropic response was mostly expressed in Daphnia magna (3.7 ± 0.4 ind (L min)−1), while in Daphnia pulex, it was reduced to 2.4 ± 0.2 ind (L min)−1, and in Cyclops vicinus, it was very small—0.16 ± 0.02 ind (L min)−1. This is caused by peculiar trophic behavior of phyto‐ and zoophages. The addition of a pollutant, namely potassium bichromate, caused a decrease in the concentration rate of crustaceans in the attracting light zone, while a dose‐dependent change in phototropic responses was observed in a group of species and the Daphnia magna assemblage.The results of laboratory studies showed high potential of using the phototropic response of zooplankton to monitor the quality of its habitat thus ensuring the early diagnostics of water pollution. Besides, the paper shows the possibility of quantifying the phototropic response of zooplankton using submersible digital holographic cameras (DHC).
Influence of environmental conditions at spawning sites and migration routes on adaptive variation and population connectivity in Chinook salmon
Authors: Alshwairikh Yara A. , Kroeze Shayla L. , Olsson Jenny , Stephens‐Cardenas Steve A. , Swain William L. , Waits Lisette P. , Horn Rebekah L. , Narum Shawn R. , Seaborn Travis 
Published: November 2021

AbstractMany species that undergo long breeding migrations, such as anadromous fishes, face highly heterogeneous environments along their migration corridors and at their spawning sites. These environmental challenges encountered at different life stages may act as strong selective pressures and drive local adaptation. However, the relative influence of environmental conditions along the migration corridor compared with the conditions at spawning sites on driving selection is still unknown. In this study, we performed genome–environment associations (GEA) to understand the relationship between landscape and environmental conditions driving selection in seven populations of the anadromous Chinook salmon (Oncorhynchus tshawytscha)—a species of important economic, social, cultural, and ecological value—in the Columbia River basin. We extracted environmental variables for the shared migration corridors and at distinct spawning sites for each population, and used a Pool‐seq approach to perform whole genome resequencing. Bayesian and univariate GEA tests with migration‐specific and spawning site‐specific environmental variables indicated many more candidate SNPs associated with environmental conditions at the migration corridor compared with spawning sites. Specifically, temperature, precipitation, terrain roughness, and elevation variables of the migration corridor were the most significant drivers of environmental selection. Additional analyses of neutral loci revealed two distinct clusters representing populations from different geographic regions of the drainage that also exhibit differences in adult migration timing (summer vs. fall). Tests for genomic regions under selection revealed a strong peak on chromosome 28, corresponding to the GREB1L/ROCK1 region that has been identified previously in salmonids as a region associated with adult migration timing. Our results show that environmental variation experienced throughout migration corridors imposed a greater selective pressure on Chinook salmon than environmental conditions at spawning sites.
Multipurpose water storage tank based DC microgrid system for isolated communities
Authors: Kumar Jaynendra , Agarwal Anshul , Singh Nitin 
Published: November 2021

AbstractRenewable energy sources can contribute a lot to deliver reliable/resilient power to isolated communities and the world's sustainable energy future. In this paper, a novel DC microgrid system has been proposed for multipurpose use for isolated communities. The system taps the unused potential of the storage water to generate electricity. The system is configured to reduce complexity and cost by reducing the sensors in the solar pumping unit. Source, storage, and loads are the parts of an isolated system. The DC microgrid includes solar PV, battery, and domestic loads (All types' loads, that is, DC, AC, and dynamic loads). Incremental conductance algorithm has been chosen for the MPPT control, and sliding mode controls have been implemented to supply the sinusoidal supply for the AC loads. The system has included a battery unit to support the DC bus voltage and stable DC microgrid operation. The centrifugal pump has been taken to operate the pump as a turbine to extract the partial power potential from the water. The proposed system's MATLAB/Simulink model was designed for a village and presented as a case study.
Entropy generation on MHD flow of a Casson fluid over a curved stretching surface with exponential space‐dependent heat source and nonlinear thermal radiation
Authors: Yusuf Tunde A. , Kareem Rasaq A. , Adesanya Samuel O. , Gbadeyan Jacob A. 
Published: November 2021

AbstractThe present model concentrates on entropy generation on a steady incompressible flow of a Casson liquid past a permeable stretching curve surface through chemical reaction and magnetic field effects. The exponential space‐dependent heat source cum heat and mass convective boundary conditions are accounted for. The resulting nonlinear boundary layer model is simplified by the transformation of similarity. Chebyshev spectral technique is involved for obtaining numerical results of the converted system of the mathematical models. Behavior of the determining thermo‐physical parameters on the profiles of velocity, temperature, concentration, skin friction, heat, mass transfer rate, rate of entropy generation, and finally the Bejan number are presented. The major point of the present investigation show that the curvature term weakens the mass transfer profile as the fluid temperature reduces all over the diffusion regime. A decrease in heat generation strengthens the species molecular bond, which prevents free Casson particle diffusion. Furthermore, the mass transfer field diminishes in suction and injection flow medium.
Imaging modalities for monitoring acute therapeutic effects after near‐infrared photoimmunotherapy in vivo
Authors: Zhang Xieyi , Nakajima Takahito , Mizoi Kenta , Tsushima Yoshito , Ogihara Takuo 
Published: November 2021

AbstractNear‐infrared photoimmunotherapy (NIR‐PIT) induces immediate cell death after irradiation with near‐infrared (NIR) light. Acute therapeutic effects caused by NIR‐PIT before the change of tumor size is essential to be monitored by imaging modalities. We summarized and compared the imaging modalities for evaluating acute therapeutic effects after NIR‐PIT, and aimed to provide a better understanding of advantages and disadvantages of each modality for evaluation in clinical applications. Fluorescence imaging and fluorescence lifetime, with high resolution, remains high accumulation of fluorescence dyes in the normal organs. High resolution and noninvasiveness are the major advantages of magnetic resonance imaging, while 18F‐fluorodeoxyglucose positron emission tomography provides information about the glucose metabolism. Optical coherence tomography provided more information about the blood vessels. Thus, all of the imaging modalities play an important role in evaluating acute therapeutic effects after NIR‐PIT. Clinicians should choose suitable modality according to specific purpose and conditions in clinical application.
Synthesis and some enzyme inhibition effects of isoxazoline and pyrazoline derivatives including benzonorbornene unit
Authors: Yavari Mirali A. , Adiloglu Yadigar , Saglamtas Ruya , Tutar Ahmet , Gulcin Ilhami , Menzek Abdullah 
Published: November 2021

AbstractFour new and four known isoxazoline derivatives were synthesized from the reactions of benzonorbornadiene with nitrile oxides formed from the corresponding benzaldehydes. Three new and one known pyrazoline derivatives were also synthesized from the reactions of the benzonorbornadiene with nitrile imines formed from the corresponding compounds. The synthesized nitrogen‐based novel heterocyclic compounds were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The synthesized nitrogen‐based novel heterocyclic compounds showed IC50 values in the range of 2.69–7.01 against hCA I, 2.40–4.59 against hCA II, 0.81–1.32 µM against AChE, and 20.83–1.70 µM against BChE enzymes. On the contrary, nitrogen‐based novel heterocyclic compounds demonstrated Ki values between 2.93 ± 0.59–8.61 ± 1.39 against hCA I, 2.05 ± 0.62–4.97 ± 0.95 against hCA II, 0.34 ± 0.02–0.92 ± 0.17 nM against AChE, and 0.50 ± 0.04–1.20 ± 0.16 µM against BChE enzymes. The synthesized nitrogen‐based novel heterocyclic compounds exhibited effective inhibition profiles against both indicated metabolic enzymes. These results may contribute to the development of new drugs particularly to treat some disorders, which are widespread in the world including glaucoma and Alzheimer's diseases.
d‐Galactose induced early aging in human erythrocytes: Role of band 3 protein
Authors: Remigante Alessia , Spinelli Sara , Trichilo Vincenzo , Loddo Saverio , Sarikas Antonio , Pusch Michael , Dossena Silvia , Marino Angela , Morabito Rossana 
Published: November 2021

AbstractAging, a time‐dependent multifaceted process, affects both cell structure and function and involves oxidative stress as well as glycation. The present investigation focuses on the role of the band 3 protein (B3p), an anion exchanger essential to red cells homeostasis, in a d‐galactose (
d‐Gal)‐induced aging model. Anion exchange capability, measured by the rate constant of SO₄²− uptake through B3p, levels of lipid peroxidation, oxidation of membrane sulfhydryl groups, B3p expression, methemoglobin, glycated hemoglobin (Hb), and the reduced glutathione/oxidized glutathione ratio were determined after exposure of human erythrocytes to 25, 35, 50, and 100 mmol/L d‐Gal for 24 h. Our results show that: (i) in vitro application of d‐Gal is useful to model early aging in human erythrocytes; (ii) assessment of B3p ion transport function is a sensitive tool to monitor aging development; (iii) d‐Gal leads to Hb glycation and produces substantial changes on the endogenous antioxidant system; (iv) the impact of aging on B3p function proceeds through steps, first involving Hb glycation and then oxidative events at the membrane level. These findings offer a useful tool to understand the mechanisms of aging in human erythrocytes and propose B3p as a possible target for new therapeutic strategies to counteract age‐related disturbances.
Effect of Anti‐VEGF Therapy on the Disease Progression of Neovascular Age‐Related Macular Degeneration: A Systematic Review and Model‐Based Meta‐Analysis
Authors: Luu Kenneth T. , Seal Jennifer , Green Michelle , Winskill Carolyn , Attar Mayssa 
Published: November 2021

AbstractAnti–vascular endothelial growth factor (VEGF) therapy is used to slow the disease progression of neovascular age‐related macular degeneration. Due to the treatment burden of frequent intravitreal injections, anti‐VEGFs are often used on treat and extend protocols rather than the labeled frequency. The current goal of anti‐VEGF drug development is to minimize treatment burden by reducing the number of intravitreal injections. The purpose of this systemic review and model‐based meta‐analysis (MBMA) was to (1) perform modeling to describe the disease progression of neovascular age‐related macular degeneration in the absence of treatment, as well as in the presence of abicipar, aflibercept, brolucizumab, or ranibizumab intervention; (2) and to simulate virtual head‐to‐head comparisons among the drugs with an extended dose schedule of once every 12 weeks (Q12). Data sources were PubMed, internal Allergan data, www.clinicaltrials.gov, and www.clinicaltrialsregister.eu. Eligibility assessment was performed by 2 independent review authors. Randomized, controlled trials that had at least 1 arm with an anti‐VEGF (aflibercept, abicipar, bevacizumab, brolucizumab, pegaptanib, or ranibizumab), a control arm of placebo or anti‐VEGF, a treatment duration of at least 4 months, reported best‐corrected visual acuity data, and at least 20 patients were included. A total of 22 trials, consisting of 55 arms, from across 9500+ subjects and 500+ best‐corrected visual acuity observations were used to develop the model. Consistent with reported data, results from the model showed that abicipar Q12 underperformed ranibizumab (every 4 weeks), aflibercept (every 4 weeks), and brolucizumab (every 8 weeks/Q12) labeled dosing schedules. However, when all drugs were virtually tested using the extended schedule, abicipar outperformed ranibizumab and aflibercept and produced a similar week 52 change from baseline as brolucizumab. Predicted week 52 changes from baseline were 5.92 ± 1.02, 3.04 ± 1.61, 6.61 ± 0.284, and 3.02 ± 2.35 best‐corrected visual acuity letters for abicipar, aflibercept, brolucizumab, and ranibizumab, respectively, using the Q12 schedule. Results demonstrate the feasibility of Q12 dosing with clinically meaningful letter gains for abicipar and brolucizumab. The model developed under this MBMA has utility for exploring different regimens for existing or novel anti‐VEGF agents.