bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an integrated peri-urban wetland degradation assessment approach for the Chatra Wetland in eastern India
Authors: Basu Tirthankar , Das Arijit , Pham Quoc Bao , Al-Ansari Nadhir , Linh Nguyen Thi Thuy , Lagerwall Gareth 
Published: February 2021

AbstractThe loss of peri-urban wetlands is a major side effect of urbanization in India in recent days. Timely and proper assessment of wetland area change is essential for the conservation of wetlands. This study follows the integrated way of the peri-urban wetland degradation assessment in the case of medium and small-size urban agglomerations with a special focus on Chatra Wetland. Analysis of land-use and land cover (LULC) maps of the past 28 years shows a decrease of 60% area of the wetland including marshy land. This has reduced the ecosystem services value by about 71.90% over the period 1991–2018. From this end, The Land Change Modeler of IDRISI TerrSet using the combination of MLPNN and Markov Chain has been used to predict the LULC map of this region. The scenario-based modeling following the LULC conversion and nine explanatory variables suggests the complete loss of this wetland by 2045. However, the authors have also tried to present a future LULC pattern of this region based on an environmental perspective. This proposed map suggests possible areas for built-up expansion on the western side of the city without significantly affecting the environment.
Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
Authors: Weightman Matthew , Brittain John-Stuart , Miall R. Chris , Jenkinson Ned 
Published: February 2021

AbstractAdaptation of movements involving the proximal and distal upper-limb can be differentially facilitated by anodal transcranial direct current stimulation (TDCS) over the cerebellum and primary motor cortex (M1). Here, we build on this evidence by demonstrating that cathodal TDCS impairs motor adaptation with a differentiation of the proximal and distal upper-limbs, relative to the site of stimulation. Healthy young adults received M1 or cerebellar cathodal TDCS while making fast ‘shooting’ movements towards targets under 60° rotated visual feedback conditions, using either whole-arm reaching or fine hand and finger movements. As predicted, we found that cathodal cerebellar TDCS resulted in impairment of adaptation of movements with the whole arm compared to M1 and sham groups, which proved significantly different during late adaptation. However, cathodal cerebellar TDCS also significantly enhanced adaptation of hand movements, which may reflect changes in the excitability of the pathway between the cerebellum and M1. We found no evidence for change of adaptation rates using arm or finger movements following cathodal TDCS directly over M1. These results are further evidence to support movement specific effects of TDCS, and highlight how the connectivity and functional organisation of the cerebellum and M1 must be considered when designing TDCS-based therapies.
Prediction of drug–target binding affinity using similarity-based convolutional neural network
Authors: Shim Jooyong , Hong Zhen-Yu , Sohn Insuk , Hwang Changha 
Published: February 2021

AbstractIdentifying novel drug–target interactions (DTIs) plays an important role in drug discovery. Most of the computational methods developed for predicting DTIs use binary classification, whose goal is to determine whether or not a drug–target (DT) pair interacts. However, it is more meaningful but also more challenging to predict the binding affinity that describes the strength of the interaction between a DT pair. If the binding affinity is not sufficiently large, such drug may not be useful. Therefore, the methods for predicting DT binding affinities are very valuable. The increase in novel public affinity data available in the DT-related databases enables advanced deep learning techniques to be used to predict binding affinities. In this paper, we propose a similarity-based model that applies 2-dimensional (2D) convolutional neural network (CNN) to the outer products between column vectors of two similarity matrices for the drugs and targets to predict DT binding affinities. To our best knowledge, this is the first application of 2D CNN in similarity-based DT binding affinity prediction. The validation results on multiple public datasets show that the proposed model is an effective approach for DT binding affinity prediction and can be quite helpful in drug development process.
Investigation of printed slot antennas based on Euclidean geometries
Authors: Mezaal Yaqeen S. 
Published: February 2021

AbstractEuclidean and fractal terms are mathematically and physically important terms in antenna design, but rarely reported studies had discussed these terms together in antenna design in their texts. This paper first gives an overview of Euclidean and fractal antennas with useful and satisfactory facts. Four printed slot antennas are then studied using Euclidean slot shapes printed in the ground plane with and without Euclidean patches using FR4 substrate. These antennas are employed to investigate their suitability as simple alternatives to complicated fractal geometries and their specific formulas. Parametric analyses with feedline lengths and patch scaling aspects are adopted to generate single, dual, and multiband responses. These parametric studies provide different outcomes and choices for antenna electrical specifications suitable for various wireless applications. It is clear that inserting Euclidean patches to the printed slot in the ground plane influence inducing multiple operating bands as similar as multiband fractal antenna, but without using specific formulas or complicated outlines. All proposed antennas have low-profile topologies, good compactness, and more competitive electrical specifications than many reported fractal antennas. The simulations of the proposed printed slot antennas are in good compatibility with the measurements.
Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
Authors: Bogdanovic A. , Bulajic P. , Masulovic D. , Bidzic N. , Zivanovic M. , Galun D. 
Published: February 2021

AbstractTo date, it is unclear which treatment modality, liver resection (LR) or transarterial chemoembolization (TACE) is the more appropriate for patients with huge (≥ 10 cm) hepatocellular carcinoma (HCC). The study aim was to compare, using propensity score matching, short- and long-term outcomes of patients with huge HCC who underwent potentially curative LR or TACE. Patients with huge HCC who had been managed at the Clinical Center by curative-intent LR or by palliative TACE between November 2001 and December 2018 were retrospectively identified. The morbidity and mortality rates and overall survival were compared between the groups before and after the propensity score matching. Independent predictors of long-term survival were determined by multivariate analysis. A total of 103 patients with huge HCC were included; 68 were assigned to the LR group and 35 to the TACE group. The overall morbidity rate was higher in the LR group than in the TACE group before matching (64.7% vs. 37.1%, p = 0.012), while there was no difference after matching (60% vs. 30%, p = 0.055). The major morbidity and 30-days mortality were similar between the groups before and after matching. The LR group was associated with longer overall survival than the TACE group before matching (p = 0.032) and after matching (p = 0.023). Total bilirubin and TACE treatment were independent prognostic factors associated with long-term survival. In patients with huge HCC, liver resection provides better long-term survival than TACE and should be considered as the initial treatment whenever possible.
Economic evaluation of variable rate nitrogen management of canola for zones based on historical yield maps and soil test recommendations
Authors: Khakbazan Mohammad , Moulin Alan , Huang Jianzhong 
Published: February 2021

AbstractCanola (Brassica napus L.) is a highly valuable crop for Canada’s economy, making the efficient management of canola a priority. A field-scale study was conducted at ten sites between 2014 and 2016 to evaluate the viability of site specific nitrogen (N) management zones (MZ) based on analysis of historical yield maps and soil test recommendations to improve canola productivity and profitability in western Canada. Treatments included factorial combinations of three canola yield zones (low, average, high) by four N rates, replicated four times at each site. The canola yield function had a quadratic form in each field but the effects of MZ varied between fields with positive effects in only a few fields. When ten site-years data were combined, MZ had positive effects on canola performance. On average, MZ of N fertilizer over ten fields generated between $28 to $65 ha−1 more net revenue (NR) relative to average yield management. Site-years, which reflect farm management and other farm characteristics had significant effects on yield and NR ranging from − $91 to $352 ha−1 compared to a baseline. Nitrogen application under MZs was only reduced by 8% compared to uniform rates. The potential for MZ does exist; however, its effectiveness is highly variable.
The environmental and ecological determinants of elevated Ross River Virus exposure in koalas residing in urban coastal landscapes
Authors: Johnson Brian J. , Robbins Amy , Gyawali Narayan , Ong Oselyne , Loader Joanne , Murphy Amanda K. , Hanger Jon , Devine Gregor J. 
Published: February 2021

AbstractKoala populations in many areas of Australia have declined sharply in response to habitat loss, disease and the effects of climate change. Koalas may face further morbidity from endemic mosquito-borne viruses, but the impact of such viruses is currently unknown. Few seroprevalence studies in the wild exist and little is known of the determinants of exposure. Here, we exploited a large, spatially and temporally explicit koala survey to define the intensity of Ross River Virus (RRV) exposure in koalas residing in urban coastal environments in southeast Queensland, Australia. We demonstrate that RRV exposure in koalas is much higher (> 80%) than reported in other sero-surveys and that exposure is uniform across the urban coastal landscape. Uniformity in exposure is related to the presence of the major RRV mosquito vector,Culex annulirostris, and similarities in animal movement, tree use, and age-dependent increases in exposure risk. Elevated exposure ultimately appears to result from the confinement of remaining coastal koala habitat to the edges of permanent wetlands unsuitable for urban development and which produce large numbers of competent mosquito vectors. The results further illustrate that koalas and other RRV-susceptible vertebrates may serve as useful sentinels of human urban exposure in endemic areas.
A new in vitro model applied 90Y microspheres to study the effects of low dose beta radiation on colorectal cancer cell line in various oxygenation conditions
Authors: Piasecki Piotr , Majewska Aleksandra , Narloch Jerzy , Maciak Maciej , Brodaczewska Klaudia , Kuc Michal , Was Halina , Wierzbicki Marek , Brzozowski Krzysztof , Ziecina Piotr , Mazurek Andrzej , Dziuk Miroslaw , Iller Edward , Kieda Claudine 
Published: February 2021

AbstractWe propose a new in vitro model to assess the impact of 90Y-microspheres derived low-dose beta radiation on colorectal cancer cell line under various oxygenation conditions that mimic the tumor environment. Cancer cells (HCT116) proliferation was assessed using Alamar Blue (AB) assay after 48, 72, and 96 h. FLUKA code assessed changes in cancer cell populations relative to the absorbed dose. In normoxia, mitochondrial activity measured by Alamar Blue after 48–72 h was significantly correlated with the number of microspheres (48 h: r = 0.87 and 72 h: r = 0.89, p < 0.05) and absorbed dose (48 h: r = 0.87 and 72 h: r = 0.7, p < 0.05). In hypoxia, the coefficients were r = 0.43 for both the number of spheres and absorbed dose and r = 0.45, r = 0.47, respectively. Impediment of cancer cell proliferation depended on the absorbed dose. Doses below 70 Gy could reduce colorectal cancer cell proliferation in vitro. Hypoxia induced a higher resistance to radiation than that observed under normoxic conditions. Hypoxia and radiation induced senescence in cultured cells. The new in vitro model is useful for the assessment of 90Y radioembolization effects at the micro-scale.
Long-term outcomes after endoscopic retrograde pancreatic drainage for symptomatic pancreaticojejunal anastomotic stenosis
Authors: Kida Akihiko , Shirota Yukihiro , Kawane Taro , Omura Hitoshi , Kumai Tatsuo , Yano Masaaki , Arihara Fumitaka , Hodo Yuji , Matsuda Koichiro , Ogawa Kohei , Matsuda Mitsuru , Sakai Akito , Terada Mitsuhiro , Wakabayashi Tokio 
Published: February 2021

AbstractThere is limited evidence supporting the usefulness of endoscopic retrograde pancreatic drainage (ERPD) for symptomatic pancreaticojejunal anastomotic stenosis (sPJS). We examined the usefulness of ERPD for sPJS. We conducted a retrospective analysis of 10 benign sPJS patients. A forward-viewing endoscope was used in all sessions. Following items were evaluated: technical success, adverse events, and clinical outcome of ERPD. The technical success rate was 100% (10/10) in initial ERPD; 9 patients had a pancreatic stent (no-internal-flap: n = 4, internal-flap: n = 5). The median follow-up was 920 days. Four patients developed recurrence. Among them, 3 had a stent with no-internal-flap in initial ERPD, the stent migrated in 3 at recurrence, and a stent was not placed in 1 patient in initial ERPD. Four follow-up interventions were performed. No recurrence was observed in 6 patients. None of the stents migrated (no-internal-flap: n = 1, internal-flap: n = 5) and no stents were replaced due to stent failure. Stenting with no-internal-flap was associated with recurrence (p = 0.042). Mild adverse events developed in 14.3% (2/14). In conclusions, ERPD was performed safely with high technical success. Recurrence was common after stenting with no-internal-flap. Long-term stenting did not result in stent failure.Clinical trial register and their clinical registration number: Nos. 58-115 and R2-9.
A comparison of the dynamical and model-derived parameters of the pulsating eclipsing binary KIC 9850387
Authors: Sekaran S. , Tkachenko A. , Johnston C. , Aerts C. 
Published: February 2021

Context. One-dimensional stellar evolutionary models incorporate interior mixing profiles as a simplification of multi-dimensional physical processes that have a significant impact on the evolution and lifetime of stars. As such, the proper calibration of interior mixing profiles is required for the reconciliation of observational parameters and theoretical predictions. The modelling and analysis of pulsating stars in eclipsing binary systems that display gravity-mode (g-mode) oscillations allows for the precise constraints on the interior mixing profiles through the combination of spectroscopic, binary and asteroseismic obervables.
Aims. We aim to unravel the interior mixing profile of the pulsating eclipsing binary KIC 9850387 by comparing its dynamical parameters and the parameters derived through a combination of evolutionary and asteroseismic modelling.
Methods. We created a grid of stellar evolutionary models using the stellar evolutionary code MESA and performed an isochrone-cloud (isocloud) based evolutionary modelling of the system. We then generated a grid of pulsational models using the stellar pulsation code GYRE based on the age constraints from the evolutionary modelling. Finally, we performed asteroseismic modelling of the observed ℓ = 1 and ℓ = 2 period-spacing patterns, utilising different combinations of observational constraints, merit functions, and asteroseismic observables to obtain strong constraints on the interior properties of the primary star.
Results. Through a combination of asteroseismic modelling and dynamical constraints, we found that the system comprises two main-sequence components at an age of 1.2 ± 0.1 Gyr. We also observed that asteroseismic modelling provided stronger constraints on the interior properties than evolutionary modelling. Overall, we found high levels of interior mixing, when compared to similar studies, for the primary star. We posited that this is a result of intrinsic non-tidal mixing mechanisms due to a similar observed behaviour in single stars. We investigated the high-frequency regime of KIC 9850387 and found evidence of the surface effect due to the systematic frequency offset of the theoretical modes from the nearest observed modes. We also found evidence of rotational splitting in the form of a prograde-retrograde dipole g1 mode doublet with a missing zonal mode, implying an envelope rotational frequency that is three times higher than the core rotational frequency and about 20 times slower than the orbital frequency, but we note that this result is based completely on the rotational splitting of a single dipole mode.
Conclusions. We find that the dynamical parameters and the parameters extracted from the asteroseismic modelling of period-spacing patterns are only barely compliant, reinforcing the need for homogeneous analyses of samples of pulsating eclipsing binaries that aim to calibrating interior mixing profiles.
Bleeding Risk Assessment in Patients with Venous Thromboembolism
Authors: Nopp Stephan , Ay Cihan 
Published: February 2021

AbstractThe recommended treatment for patients with venous thromboembolism (VTE) is anticoagulation for at least 3 months. However, anticoagulant treatment increases the risk of bleeding, and patients at high risk for major bleeding might benefit from treatment discontinuation. In this review, we discuss strategies for assessing bleeding risk and compare different bleeding risk tools. Bleeding risk assessment is best viewed as a continuous approach with varying challenges throughout the acute and chronic phase. At diagnosis, bleeding risk factors must be identified and reversible risk factors treated or modified. After initial treatment, repeated bleeding risk assessment is crucial for the decision on extended/long-term anticoagulation. Current clinical prediction models (e.g., HAS-BLED, RIETE, or VTE-BLEED scores) are externally validated tools with relevant differences in specificity and sensitivity, which can aid in clinical decision-making. Unfortunately, none of the current bleeding risk assessment tools has been investigated in clinical trials and provides evidence to withhold anticoagulation treatment based on the score. Nevertheless, the HAS-BLED or RIETE score can be used to identify patients at high risk for major bleeding during the initial treatment phase, while the VTE-BLEED score might be used to identify patients at low risk for bleeding and, therefore, to safely administer extended/long-term anticoagulation for secondary thromboprophylaxis. As clinical prediction scores still lack predictive value, future research should focus on developing biomarker-based risk assessment models.
COVID-19-Pandemie und Versorgung schwer psychisch erkrankter Menschen – Inwieweit wurden die Interessen psychisch erkrankter Menschen in den Schutzverordnungen des Bundes und der Länder berücksichtigt?
Authors: Schomerus Georg , Stengler Katarina , Fasshauer Jonathan Mathias 
Published: February 2021

Zusammenfassung
Ziel der Studie Verordnungen während des ersten COVID-19-„Lockdowns“ in Deutschland wurden analysiert bezüglich ihrer Auswirkungen auf psychisch erkrankte Menschen.
Methodik In die Auswertung wurden im Zeitraum 1. März 2020 bis 30. Juni 2020 gültige Verordnungen mit Gesundheitsaspekten einbezogen.
Ergebnisse In insgesamt 344 identifizierbaren Verordnungen wurden psychiatrische Versorgungsstrukturen insgesamt deutlich eingeschränkt, wobei Menschen mit psychischen Krankheiten selten dezidiert erwähnt wurden. Ausmaß und zeitliche Dauer der Einschränkungen unterschieden sich zwischen den Bundesländern.
Schlussfolgerung Die Belange von Menschen mit psychischen Krankheiten sollten zukünftig stärker Berücksichtigung finden.
Ambulatory Use of Handheld Point-of-Care Ultrasound (HH-POCUS) in Rural Brandenburg – A Pilot Study
Authors: Lo Hendra , Frauendorf Vilmar , Wischke Sandra , Schimmath-Deutrich Christin , Kersten Markus , Nuernberg Maria , Nuernberg Dieter , Jenssen Christian 
Published: February 2021

Abstract
Purpose This study aims to evaluate the use of handheld ultrasound devices (HHUS) for point-of-care ultrasound (POCUS) to improve outpatient care in rural Brandenburg.
Materials and Methods A group of general practitioners (n = 9), palliative care physicians (n = 6), emergency physicians (n = 4), and nurses from palliative care services (n = 5) participated in this study. Following a 3-hour workshop and 2 weeks of individual training, participants performed POCUS using HHUS (HH-POCUS). Indications, examination results, and resulting treatment changes (e. g., acute interventions, new medication) were documented in a standardized data entry form.
Results 19 physicians with different ultrasound experience and 5 palliative care nurses attended the workshop program and took part in the study. Three of the participating physicians were out of training in ultrasound and received prolonged supervision. Among 427 HH-POCUS examinations, the FAST scan and kidney scan were performed most often. Pain and dyspnea were the most common indications for HH-POCUS. Among the examinations performed by physicians (n = 311), ascites was the most common pathology (27 % of cases). Using a simplified examination protocol, palliative care nurses diagnosed fluid collections, hydronephrosis and transurethral catheter position or urinary retention. In 80.4 % of physician-performed cases, HH-POCUS made a valuable impact on patient management. HH-POCUS contributed to treatment decisions in 49.5 % of cases, including a change of medication in 29.6 % and performance of therapeutic interventions in 19.9 %. Hospital admission or referral to an ambulatory specialist was initiated due to HH-POCUS findings in 17.7 % of patients.
Conclusion HH-POCUS helped doctors in rural areas to optimize patient care through rapid on-site collection of therapeutically relevant findings. In addition, it was shown that specialized and motivated nurses can independently detect simple ultrasound findings and thus provide clinically relevant information to doctors.
An Effective Route to Dithieno[3,2-b:2′,3′-d]thiophene-Based Hexaheteroacenes
Authors: Irgashev Roman A. , Demina Nadezhda S. , Bayankina Polina E. , Kazin Nikita A. , Rusinov Gennady L. 
Published: February 2021

AbstractA series of 12H-[1]benzo[4′′,5′′]thieno[2′′,3′′:4′,5′]thieno[2′,3′:4,5]thieno[3,2-b]indoles were efficiently prepared in three steps starting from available benzo[b]thieno[2,3-d]thiophen-3(2H)-ones. These fused ketones were treated with the Vilsmeier reagent and hydroxylamine hydrochloride to give the corresponding 3-chlorobenzo[b]thieno[2,3-d]thiophene-2-carbonitriles, which then reacted with methyl sulfanylacetate to form methyl 3-aminobenzo[4′,5′]thieno[2′,3′:4,5]thieno[3,2-b]thiophene-2-carboxylates, in accordance with the Fiesselmann thiophene synthesis protocol. Finally, the desired N,S-heterohexacenes were obtained by conversion of these fused 3-aminothiophene-2-carboxylates into the corresponding 3-aminothiophene intermediates, which acted as synthetic equivalents of thiophen-3(2H)-ones, followed by their acid-promoted reaction with arylhydrazines, in accordance with the Fischer indolization procedure.