bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized rehabilitation program for older patients with osteoarthritis
Authors: Panikar V. I. , Korshun E. I. , Anikin S. G. , Bochko O. V. , Voronina E. A. , Silyutina M. V. , Kravchenko E. S. 
Published: June 2021

Objective: to develop a personalized rehabilitation program for improving age-related resilience (AR), antioxidant status (AOS), the quality of life and reducing pain in elderly patients with osteoarthritis (OA).Patients and methods. The program consisted of two parts. In the first part, we conducted a comparative study to assess the AR (Mahnach test), geriatric status, and AOS (amperometric flow-injection analysis) in 181 subjects in total, with coxarthrosis (n=92) and without it (n=89). The average age of patients in two groups was comparable: 72.1±1.1 and 71.9±1.1 years. Using factor analysis, we developed the personalized rehabilitation program based on the obtained data. The effectiveness of the program was evaluated in the second part of our work. We conducted an additional comparative study of changes in AR, AOS, severity of joint pain (by visual analogue scale, VAS) and quality of life (according to SF-36 questionnaire) in patients with coxarthrosis (n=114).Results and discussion. Patients with coxarthrosis had significantly lower level of AR, total antioxidant, and antiradical activity, and a higher content of Schiff bases as compared to subjects without coxarthrosis (p<0.05). The program of rehabilitation, which included a course of treatment with Chondroquard, significantly improved AR, AOS, quality of life and reduced hip pain compared to the standard OA therapy (p<0.05).Conclusion. The personalized rehabilitation program has a complex positive effect on pain, quality of life, AR and AOS in elderly patients with OA.
PIP5K2A (rs10828317) polymorphism in patients with alcohol dependence and affective disorders
Authors: Mikhalitskaya E. V. , Vyalova N. M. , Fedorenko O. Yu. , Roshchina O. V. , Simutkin G. G. , Bokhan N. A. , Ivanova S. A. 
Published: June 2021

Alcohol dependence (AD) and affective disorders (ADs) are serious medical and socio-economic problems of modern society. It is hypothesized that both disorders share a common neurobiological basis. Phosphatidylinositol-4-phosphate-5-kinase type 2 alpha (PIP5K2A) plays an essential role in neuronal phosphoinositide signaling pathways. Nonsynonymous rs10828317 mutation of the PIP5K2A gene leads to conformational changes of the PIP5K2A protein and a decrease in the functional activity of this enzyme. In this study, we assessed the possibility of using the rs10828317 polymorphic variant of the PIP5K2A gene as a marker of AD and ADs.Objective: to study the associations of the PIP5K2A (rs10828317) polymorphism with AD and ADs clinical course.Patients and methods. We enrolled 255 patients with AD and 325 patients with ADs. 126 patients with AD and 71 patients with ADs underwent a comprehensive clinical, clinical-dynamic, psychodiagnostic assessment using a set of clinical scales and tests, including Structured Interview Guide For The Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH-SAD), Alcohol Use Disorders Identification Test (AUDIT), The Obsessive-Compulsive Drinking Scale for craving in alcohol (OCDS).Results and discussion. PIP5K2A (rs10828317) polymorphism in patients with AD was associated with the OCDS mean score after the inpatient treatment; in patients with ADs - with the severity of atypical depression symptoms assessed by SIGH-SAD at the time of admission.Conclusion. The results of our pilot study indicate the involvement of PIP5K2A (rs10828317) polymorphism in the AD and ADs pathophysiology.
Do We Need Basic Income Experiments?
Authors: Torry Malcolm 
Published: June 2021

Abstract
In this article ‘Basic Income’, ‘Basic Income scheme’, ‘experiment’ and ‘pilot project’ will be defined, and Basic Income pilot projects in Namibia and India will be distinguished from Minimum Income Guarantee experiments in the USA and Canada and the ambiguous pilot project in Finland. The conditions for running a genuine Basic Income pilot project in a country with a more developed economy will then be outlined, and microsimulation will be found to be the only reliable method for testing a Basic Income scheme for financial feasibility. The conclusion will be drawn that microsimulation can provide many of the results that a pilot project would deliver, but that pilot projects of financially feasible Basic Income schemes might still be useful to test dynamic macroeconomic and labour market effects.
The effect of hyperparameter search on artificial neural network in human activity recognition
Authors: Suto Jozsef 
Published: June 2021

Abstract
In the last decade, many researchers applied shallow and deep networks for human activity recognition (HAR). Currently, the trending research line in HAR is applying deep learning to extract features and classify activities from raw data. However, we observed that, authors of previous studies have not performed an efficient hyperparameter search on their artificial neural network (shallow or deep)-based classifier. Therefore, in this article, we demonstrate the effect of the random and Bayesian parameter search on a shallow neural network using five HAR databases. The result of this work shows that a shallow neural network with correct parameter optimization can achieve similar or even better recognition accuracy than the previous best deep classifier(s) on all databases. In addition, we draw conclusions about the advantages and disadvantages of the two hyperparameter search techniques according to the results.
Influence of Turn-Rolling on the Residual Stresses and Microstructure of C45E and the Effects on Fatigue Life under Cyclic Loading
Authors: Denkena B. , Kuhlemann P. , Breidenstein B. , Keitel M. , Vogel N. 
Published: June 2021

Abstract
The microstructure and the residual stress state have a significant influence on the service life of the component. The deep rolling process already enables a significant increase in the strength and service life of highly stressed components. By using the hybrid manufacturing process of turn rolling, the edge zone properties can be influenced to such an extent that the service life is further increased compared to conventional deep rolling. In addition to a change in the residual stress state, the use of the turning process temperature also leads to a significant grain refinement in the edge zone area, which has a positive effect on the component service life. This modification of the edge zone can be significantly influenced by the machining speed.
Investigation of Compound Layer Structures after Nitriding and Nitrocarburizing of Quenched and Tempered Steels
Authors: Sommer M. , Hoja S. , Steinbacher M. , Fechte-Heinen R. 
Published: June 2021

AbstractA compound layer is formed by ingress of nitrogen from an external nitrogen source into the surface layer and the formation of nitrides when the solubility of nitrogen in the bulk material is exceeded. In the surface layer, where the nitrogen concentration is at its maximum level, the nitrides form a closed layer. The compound layer continues to contain alloy nitrides which have formed from the carbides and other precipitates from the bulk material. The properties of the compound layer have a decisive influence on the wear and fatigue behavior of the loaded surfaces. The current investigations deal with the extensive characterization of compound layers that have been produced in heat treatment processes with the aim of producing stress-resistant nitriding layers. The commonly used nitriding and quench and temper (Q&T) steels 31CrMoV9 and 42CrMo4 served as examination material. The structure of the compound layers was varied within the nitriding trials regarding the phase composition, porosity and layer thicknesses. The phase composition of the compound layers was determined by special etching, scanning electron microscopy (SEM), X-ray diffraction and GDOES.
Characterization of Graded Subsurface Zones in Industrial Case-Hardening Using a Non-Destructive Testing System
Authors: Gansel R. , Zimmermann C. , Fricke L. V. , Lüdtke M. , Klümper-Westkamp H. , Fechte-Heinen R. , Maier H. J. , Zaremba D. 
Published: June 2021

Abstract
For process monitoring and quality assurance of case-hardened components, the determination of the case-hardening depth in the manufacturing process after hardening of the subsurface layer is a quality verification that is often required in industry. Currently, these quality assurance tests can only be realized with destructive measures. During case-hardening, the essential microstructural formation, and thus the key component properties are developed during the heat treatment in the cooling section. The testing technique used in the present study is based on the analysis of harmonic signals of eddy current testing. The aim of this project was to achieve an early identification of incorrect cooling processes in the case of a known transformation behaviour of the components during cooling. The data collected in the industrial hardening process show that an evaluation of the carburizing process on the basis of the case-hardening depth can be carried out non-destructively during component cooling and in the cooled state with the use of eddy current technology.
The impact of European legal acts on national legal terminology and on German as a minority language in South Tyrol, Italy
Authors: Kranebitter Klara 
Published: June 2021

Abstract
Legal concepts are generally deeply rooted in a specific legal system. Even when two legal systems use the same official language, such as Germany and Austria, the system-boundness of their legal concepts may lead to communication problems. German is also an officially recognised minority language in South Tyrol, Italy. In South Tyrol, the local public authorities must use the minority language in their relations with German-speaking citizens. This brought about the need to elaborate a local German legal terminology to express Italian legal concepts. Terminology development efforts intended to promote terminology consistency and avoid an excessive regionalisation of South Tyrolean German, so as to foster communication with the neighbouring German-speaking legal systems. In the last decades, European Union law has led to a growing harmonisation in the legal terminologies of its Member States, facilitating communication between the different legal systems, also with benefits for terminology work in South Tyrol. This paper focuses on how European legal acts impact on national legal terminology and affect German legal terminology in South Tyrol. The considerations set out are based on comparative legal terminology work regarding the Italian and the German-speaking legal systems done at Eurac Research.
Optimal removal of iron impurities from kaolin by combination of Aspergillus niger & Bacillus subtilis
Authors: Fakharpour Mahsa , Hajihoseini Jalal 
Published: June 2021

Abstract
This study was carried out to remove iron from kaolin using a biological method by two different species of Bacillus sp. and the combination of A. niger isolated from pistachio skin & Bacillus subtilis and comparing them with the control sample. The experiments were carried out for Bacillus sp. at 30 °C and 25 °C and for the combination of A. niger & Bacillus subtilis at 27 °C. The concentration of dissolved iron increased with increasing temperature in the samples treated with Bacillus sp. X-ray fluorescence spectroscopy results of the samples at 25 °C showed a reduction of 31.1% in Fe2O3 and Fe content and a reduction of 37% at 30 °C after 28 days. Therefore, iron removal by Bacillus subtilis at 30 °C achieves better performance than at 25 °C. X-ray fluorescence spectroscopy results of the samples treated with the combination of A. niger & Bacillus subtilis show a decrease of 49% in Fe2O3 and Fe content at 27 °C after 14 days. The results of colour measurement showed that kaolin powder treated with the combination of A. niger & Bacillus subtilis at 27 °C had the highest degree of whiteness compared to other samples.
Rational belief and Dialetheism
Authors: Bonardi Paolo 
Published: June 2021

AbstractIt is usually maintained that a subject with manifestly contradictory beliefs is irrational. How can we account, then, for the intuitive rationality ofdialetheists, who believe that some manifest contradictions are true? My paper aims to answer this question. Its ultimate goal is to determine a characterization of (or rather a constraint for) rational belief approvable by both the theorists of Dialetheism and its opponents. In order to achieve this goal, a two-step strategy will be adopted. First, a characterization of rational belief applicable to non-dialetheist believers will be determined; this characterization will involve the semantic apparatus of Nathan Salmon’s Millian Russellianism but will get rid of the problematic and obscure notion of mode of presentation (guisein his own terminology), replacing it with a couple of novel devices,belief subsystemsandcognitive coordination. Second, using ideas from Graham Priest, the leading proponent of Dialetheism, such a characterization will be modified, so as to devise a new one able to account for the intuitive rationality of both dialetheist and non-dialetheist believers.
Hear, Here: Oral History, Gentrification, and Memory Politics
Authors: Beaujot Ariel , Hamilton Michelle A. 
Published: June 2021

Abstract

Hear, Here is a critical oral history project developed in two gentrifying urban neighborhoods in Canada and the United States. Recorded by our university students, residents and visitors can listen to short first-person stories on their cell phones, the location of which is marked by orange street signs with a toll-free phone number. The process of gentrification results in community groups staking claims to their version of history embodied in the built heritage and cultural landscapes under threat by neglect and demolition. Hear, Here seeks to amplify the voices of those who typically go unheard, and advocates that oral history can be used to challenge policy, preserve diversity, and reveal that gentrification is not inherent in urban change.
Acromesomelic dysplasia-Maroteaux type, nine patients with two novel NPR2 variants
Authors: Kılıç Esra , Çavdarlı Büşranur , Büyükyılmaz Gönül , Kılıç Mustafa 
Published: June 2021

Abstract

Objectives
Acromesomelic dysplasia, type Maroteaux, is an autosomal recessive skeletal dysplasia caused by biallelic loss of function variations of NPR2, which encodes a cartilage regulator C-type natriuretic peptide receptor B. NPR2 variations impair skeletal growth. It is a rare type of dwarfism characterized by shortening of the middle and distal segments of the limbs with spondylar dysplasia.

Methods
We performed detailed clinical and radiological evaluation and sequence analysis for NPR2.

Results
Herein, we report nine patients from eight families with two novel NPR2 pathogenic variants.

Conclusions
This study describes typical clinical phenotypes of Maroteaux type acromesomelic dysplasia, and enriches the variant spectrum of NPR2 by reporting one nonsense and one missense novel variant. We emphasize the importance of detailed clinical evaluation before genetic testing in diagnosing rare skeletal disorders.
The presentation of congenital adrenal hyperplasia in an unscreened population
Authors: Conlon Tracey A. , Hawkes Colin P. , Brady Jennifer J. , Murphy Nuala P. 
Published: June 2021

Abstract

Background
The aim of this study was to describe the incidence and spectrum of early clinical presentations of congenital adrenal hyperplasia (CAH) in an unscreened population.

Methods
A national retrospective observational study was undertaken to identify all children diagnosed with CAH in the Republic of Ireland, between January 2005 and December 2019. Reporting clinicians completed anonymized clinical questionnaires.

Results
There were 103 cases of CAH reported and 69 cases met the study inclusion criteria. The estimated annualized incidence of CAH in the Republic of Ireland was 1:14,754 or 0.07 cases per 1,000 live births. Forty-seven children presented clinically in the first six months of life, but only 17 of these had a confirmed diagnosis by day 10. Of these early presentations, there were 28 infants with salt-wasting, 15 females presented with virilized genitalia and four infants were detected due to a family history of CAH. Female infants presented at a median age of 0 days [IQR 0–1] and males at 14 days [IQR 9–21]. Seventy-eight percent of salt-wasting presentations occurred after day 10. Delays in clinical presentation, biochemical diagnosis and treatment initiation were identified.

Conclusions
The incidence of CAH is higher in Ireland than in other unscreened populations. In the absence of screening, clinicians should be aware of the possibility of CAH and appropriate investigations should be urgently requested. Life-threatening salt-wasting is the most frequent clinical presentation and many cases could be detected prior to decompensation if newborn screening were introduced.
Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche
Authors: Topaktaş Eylem , Erolu Elif , Dursun Fatma , Kırmızıbekmez Heves 
Published: June 2021

Abstract

Objectives
Premature adrenarche may be associated with an intrauterine programmed metabolic syndrome which should be considered as a warning sign for coronary heart disease due to accelerated atherosclerosis, hypertension, type 2 diabetes mellitus (DM), and polycystic ovary syndrome.

Methods
Seventy-three patients with premature adrenarche were evaluated for metabolic parameters and aortic elasticity to evaluate the susceptibility to atherosclerosis and compared with a control group. The patients were examined in two groups as overweight and nonoverweight, and metabolic and cardiac parameters were also compared among these groups. Strain, distensibility, and stiffness index parameters were used to evaluate aortic elasticity.

Results
Biochemical parameters and cardiac measurements were not statistically different between patients and controls. They also did not differ between patients with normal weight and overweight groups. Atherogenic index and insulin resistance were closely related and a positive correlation between cholesterol and triglyceride, and ascending aortic stiffness was found.

Conclusions
The results may suggest that cholesterol and triglyceride-related arterial involvement is more involved in the pathogenesis of arterial stiffness. It can be considered that ‘being overweight’ or ‘having metabolic profile characterized by insulin resistance and dyslipidemia’ are the major coexisting factors influencing the vascular structure, rather than increased androgens and premature adrenarche itself.
Molecular and clinical findings of Turkish patients with hereditary fructose intolerance
Authors: Gunduz Mehmet , Ünal-Uzun Özlem , Koç Nevra , Ceylaner Serdar , Özaydın Eda , Kasapkara Çiğdem Seher 
Published: June 2021

Abstract

Objectives
Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by a deficiency in aldolase B that can result in hypoglycemia, nausea, vomiting, abdominal pain, liver and kidney dysfunction, coma, and even death. This study aims to represent the clinical features and molecular genetic analysis data of the patients diagnosed with HFI in our study population.

Methods
The medical records of the 26 patients with HFI were evaluated retrospectively. Age, gender, clinical findings, metabolic crises, and the results of molecular analyses were recorded.

Results
The patients with HFI had a good prognosis and the aversion to sugar-containing foods was the main complaint. Seven different variants were identified in the Aldolase B (ALDOB) gene in HFI patients. The most frequent mutations were p.Ala150Pro, p.Ala175Asp had a prevalence of 61 and 30%, respectively, in agreement with the literature and other known variants were found with minor frequencies c.360-363del4(3.8%), p.Asn335Lys(3.8%), and three novel mutations c.113-1_15del4 (3.8%), p.Ala338Val(7.6%), and p.Asp156His(3.8%) were identified at a heterozygous, homozygous, or compound heterozygous level.

Conclusions
This study results revealed three novel mutations in patients with HFI. On the basis of age of presentation, clinical symptoms, and metabolic crisis, there was no clear-cut genotype-phenotype correlation. This article also demonstrates the importance of screening suspected infants in cases of acute liver failure for prompt diagnosis and treatment of HFI.
Evaluation of raw, treated and effluent water quality from selected water treatment plants: a case study of Lagos Water Corporation
Authors: Yusuf Kafeelah , Majolagbe Abdulrafiu , Balogun Sherifat 
Published: June 2021

Abstract
Water plays a significant role in maintaining human health and welfare. In this paper, eight selected water treatment plants (lshasi, Iju, Adiyan, Mosan Okunola, Ikorodu, Otta-ikosi, Alausa and Akilo) controlled by Lagos Water Corporation were studied to evaluate raw, treated and effluent water quality. Sixteen parameters (pH, Turbidity, Electrical Conductivity (EC), Total Dissolved Solids (TDS), Total Alkalinity (TA), Total Hardness (TH), Calcium (Ca2+), Magnesium (Mg2+), Chloride (Cl−), Sulphate (SO4
2−), Nitrate (NO3
−), Phosphate (PO4
3−), Total Coliform (TC), Copper (Cu2+), Cadmium (Cd2+) and Lead (Pb2+) were determined for a period of three months (July–September 2018) using standard methods. The results showed that Cd was not detected; the TC exceeded the World Health Organization (WHO) limit while all other parameters were within the (WHO) guideline for drinking purposes with the exception of turbidity. The values of water quality index (WQI) designated 70.83% as excellent water, 20.83% as good water and 8.33% as poor water in respect to drinking uses. The Principal Component Analysis (PCA) extracts five components with eigenvalue >1.0 and accounts for 78.22% of the total variance. The associated health risks were estimated for adults and children. The hazard quotients (HQ) were greater than one indicating an overall health risk for adults and children.
Model reduction for Smoluchowski equations with particle transfer
Authors: Timokhin Ivan , Matveev Sergey , Tyrtyshnikov Eugene , Smirnov Alexander 
Published: June 2021

Abstract
In this paper we consider the problem of modelling a system of aggregating particles, that are being transported with stationary velocities dependent on masses of the particles in one-dimensional case. A numerical method based on the ideas of POD (Proper Orthogonal Decomposition) is constructed, and its capacity to speed up the solution up to 40 times is demonstrated.
Rituell unmusikalisch? Resonanzen in psychoanalytischen und theologischen Kontexten
Authors: Odenthal Andreas 
Published: June 2021

ZusammenfassungAusgehend vom Freud’schen Garnrollenspiel werden Rituale als eine Möglichkeit des Kindes gedeutet, mit der frühen Verlusterfahrung der Mutter kreativ umzugehen und den Freiraum des eigenen Lebens zu entdecken. Anknüpfend an Donald W. Winnicott kann der kulturelle Bereich insgesamt als ein dritter Wirklichkeitsbereich verstanden werden, in dem der Doppelwunsch nach Schutz und Trost einerseits sowie nach Aufbruch und Selbstwerdung andererseits seinen Ausdruck findet. Dieses Konzept wird mit der theologischen Definition des Gottesdienstes als „Feier des Pascha-Mysterium“ vermittelt: Das Volk Israel vergewissert sich im Pascha-Mahl des Schutzes seines Gottes und kann den Schritt in die Befreiung aus der Sklaverei Ägyptens tun. Jesus versichert sich beim Letzten Abendmahl des Schutzes seines Gottes und kann den entscheidenden Schritt in sein Leiden, Sterben und Auferstehen tun, was für die glaubenden Menschen als das befreiende Heilsereignis angesehen wird. Der Resonanzraum Gottesdienst verbindet so Lebensgeschichte und Heilsgeschichte (rituelle Erfahrung). Der interdisziplinäre Dialog von Psychoanalyse und Theologie ermöglicht so tiefe Einsichten in die Bedeutung des Rituellen für die Menschen.