bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental factors impacting the motivation to innovate: a systematic review
Authors: Soleas Eleftherios 
Published: June 2021

AbstractThe environments where innovation occurs are often as varied as the areas of endeavors that aspiring innovators could pursue. This systematic review followed the guidelines of the Campbell Collaboration and PRISMA to consolidate the findings of 74 studies into the Expectancy-Value-Cost motivation theoretical framework as a means of usefully isolating for decision-makers the environmental factors that impact the motivation to innovate. The results of this review reveal that additional study of interdisciplinary samples is needed to gather deep narrative and case-driven data that considers the experiences of innovators in addition to organizations. Leaders, including decision-makers, teachers, and supervisors, can set a precedent for their learners and workers to use their past experiences and to feel safe to take intelligent risks and make reasonable mistakes in pursuit of innovating. Ensuring that project teams have a mix of experiences and backgrounds can make for more productive collaborations. Proactively addressing costs can increase workplaces’ psychological safety and stability, which enables workers and learners to better focus on the endeavors at hand. The articles’ evaluation illustrates that conversation about innovation promotion is dominated by business, which reduces the opportunity to learn from other innovation-driven disciplines or take truly interdisciplinary approaches.
Evidence on the effectiveness of small unmanned aircraft systems (sUAS) as a survey tool for North American terrestrial, vertebrate animals: a systematic map protocol
Authors: Elmore Jared A. , Curran Michael F. , Evans Kristine O. , Samiappan Sathishkumar , Zhou Meilun , Pfeiffer Morgan B. , Blackwell Bradley F. , Iglay Raymond B. 
Published: June 2021

Abstract
Background
Small unmanned aircraft systems (sUAS) are replacing or supplementing manned aircraft and ground-based surveys in many animal monitoring situations due to better coverage at finer spatial and temporal resolutions, access, cost, bias, impacts, safety, efficiency, and logistical benefits. Various sUAS models and sensors are available with varying features and usefulness depending on survey goals. However, justification for selection of sUAS and sensors are not typically offered in published literature and existing reviews do not adequately cover past and current sUAS applications for animal monitoring nor their associated sUAS model and sensor technologies, taxonomic and geographic scope, flight conditions and considerations, spatial distributions of sUAS applications, and reported technical difficulties. We outline a systematic map protocol to collect and consolidate evidence pertaining to sUAS monitoring of animals. Our systematic map will provide a useful synthesis of current applications of sUAS-animal related studies and identify major knowledge clusters (well-represented subtopics that are amenable to full synthesis by a systematic review) and gaps (unreported or underrepresented topics that warrant additional primary research) that may influence future research directions and sUAS applications.

Methods
Our systematic map will investigate the current state of knowledge using an accurate, comprehensive, and repeatable search. We will find relevant peer-reviewed and grey literature as well as dissertations and theses using online publication databases, Google Scholar, and by request through a professional network of collaborators and publicly available websites. We will use a tiered approach to article exclusion with eligible studies being those that monitor (i.e., identify, count, estimate, etc.) terrestrial vertebrate animals. Extracted data concerning sUAS, sensors, animals, methodology, and results will be recorded in Microsoft Access. We will query and catalogue evidence in the final database to produce tables, figures, and geographic maps to accompany a full narrative review that answers our primary and secondary questions.
Epidemiology and outcomes of bloodstream infections in severe burn patients: a six-year retrospective study
Authors: Hu Yangmin , Li Danyang , Xu Lingcheng , Hu Yuping , Sang Yiwen , Zhang Gensheng , Dai Haibin 
Published: June 2021

Abstract
Background
Infection is the leading cause of morbidity and mortality among burn patients, and bloodstream infection (BSI) is the most serious. This study aimed to evaluate the epidemiology and clinical outcomes of BSI in severe burn patients.

Methods
Clinical variables of all patients admitted with severe burns (≥ 20% total body surface area, %TBSA) were analyzed retrospectively from January 2013 to December 2018 at a teaching hospital. The Kaplan–Meier method was utilized for plotting survival curves. Multivariate logistic regression and Cox regression model were also performed.

Results
A total of 495 patients were evaluated, of whom 136 (27.5%) had a BSI. The median time from the patients being burned to BSI was 8 days. For BSI onset in these patients, 47.8% (65/136) occurred in the first week. The most frequently isolated causative organism was A. baumannii (22.7%), followed by methicillin-resistant Staphylococcus aureus (18.7%) and K. pneumoniae (18.2%), in patients with BSI. Multivariate logistic regression analysis showed that %TBSA (p = 0.023), mechanical ventilation (p = 0.019), central venous catheter (CVC) (p < 0.001) and hospital length of stay (27d vs 50d, p < 0.001) were independent risk factors associated with BSI. Cox regression model showed that acute kidney injury (HR, 12.26; 95% CI 2.31–64.98; p = 0.003) and septic shock (HR, 4.36; 95% CI 1.16–16.34; p = 0.031) were identified as independent predictors of 30-day mortality of BSI in burn patients.

Conclusions
Multidrug resistant gram-negative bacteria were the main pathogens of BSI in severe burn patients. Accurate evaluation of risk factors for BSI and the mortality of BSI in severe burn patients may improve early appropriate management.
Is this the ‘new normal’? A mixed method investigation of young person, parent and clinician experience of online eating disorder treatment during the COVID-19 pandemic
Authors: Stewart Catherine , Konstantellou Anna , Kassamali Fatema , McLaughlin Natalie , Cutinha Darren , Bryant-Waugh Rachel , Simic Mima , Eisler Ivan , Baudinet Julian 
Published: June 2021

Abstract
Introduction
Prior to the COVID-19 pandemic, research in virtual care for young people with eating disorders was preliminary and implementation rare. This study explored the experience of young people, parents and clinicians when therapy was transitioned to virtual provision as a result of the UK lockdown in March 2020.

Methods
A mixed-method approach was used in this study. Online questionnaires that included a mixture of rating (Likert scale) and free-text response questions were completed by 53 young people with any eating disorder, 75 parents and 23 clinicians. Questions focused on the experience of online treatment as well as the impact on engagement, perceived treatment efficacy and preferences around treatment mode in the future. Likert scale questions were analysed using a summary approach. Free-text responses were analysed qualitatively using reflexive thematic analysis.

Results
Responses to rating scale questions indicate satisfaction with treatment, good engagement and ability to manage technology. Young people who had transitioned care, rather than started care virtually in lockdown, rated therapy as less effective. However, individual accounts of experience were more varied. Reflexive thematic analysis of free-text responses identified key themes of 1) Making it work, 2) Home as a therapeutic space, and 3) Disrupted connection and 4) Into the future.

Conclusions
These results have implications for ongoing care during the pandemic and for future implementation of virtual care in the treatment of young people with eating disorders. Particular issues arising are the trade-off between accessibility and therapeutic engagement and depth and need for consideration of equal access to treatment in socially unequal societies.
Lao Tze and Confucius' philosophies influenced the designs of Kisho Kurokawa and Tadao Ando
Authors: Trisno Rudy , Lianto Fermanto 
Published: June 2021

AbstractJapanese architecture retains the characteristic of appreciating its culture, despite the growing influence of Western architecture. Based on this issue, it is a very interesting area to study to understand the design concepts behind two masterpieces from the world’s architects Kisho Kurokawa and Tadao Ando. This study uses a qualitative method by analyzing theories and case studies in the work of the architects Kisho Kurokawa and Tadao Ando. It conducts the following detailed analyses; (a) Western architects who influenced both design concepts; (b) The primary considerations of the two architects in facing the demands of the times. The study concludes that Kisho Kurokawa was influenced by Kenzo Tange, while Tadao Ando has been influenced by Le Corbusier and Louis Khan. The primary consideration of Kisho Kurokawa is Hanasuki, while for Tadao Ando it is Shintai. The findings in this study are that the two architects in the design concept were inspired by Japanese culture, where Japanese culture is influenced by the philosophy of Lau Tze and Confucius.
Machine learning to identify geologic factors associated with production in geothermal fields: a case-study using 3D geologic data, Brady geothermal field, Nevada
Authors: Siler Drew L. , Pepin Jeff D. , Vesselinov Velimir V. , Mudunuru Maruti K. , Ahmmed Bulbul 
Published: June 2021

AbstractIn this paper, we present an analysis using unsupervised machine learning (ML) to identify the key geologic factors that contribute to the geothermal production in Brady geothermal field. Brady is a hydrothermal system in northwestern Nevada that supports both electricity production and direct use of hydrothermal fluids. Transmissive fluid-flow pathways are relatively rare in the subsurface, but are critical components of hydrothermal systems like Brady and many other types of fluid-flow systems in fractured rock. Here, we analyze geologic data with ML methods to unravel the local geologic controls on these pathways. The ML method, non-negative matrix factorization withk-means clustering (NMFk), is applied to a library of 14 3D geologic characteristics hypothesized to control hydrothermal circulation in the Brady geothermal field. Our results indicate that macro-scale faults and a local step-over in the fault system preferentially occur along production wells when compared to injection wells and non-productive wells. We infer that these are the key geologic characteristics that control the through-going hydrothermal transmission pathways at Brady. Our results demonstrate: (1) the specific geologic controls on the Brady hydrothermal system and (2) the efficacy of pairing ML techniques with 3D geologic characterization to enhance the understanding of subsurface processes.
A long-term survivor of metachronous liver metastases of pancreatic serous cystic neoplasm associated with von Hippel–Lindau disease
Authors: Kokumai Takashi , Mizuma Masamichi , Hirose Katsuya , Karasawa Hideaki , Ishida Masaharu , Ohtsuka Hideo , Nakagawa Kei , Morikawa Takanori , Kamei Takashi , Masamune Atsushi , Furukawa Toru , Unno Michiaki 
Published: June 2021

Abstract
Background
Pancreatic serous cystic neoplasm (SCN) is an uncommon exocrine neoplasm, which is believed to be a benign entity. However, some of these neoplasms may occasionally attain metastatic ability. Von Hippel–Lindau disease (VHL) manifests a dominantly inherited systemic syndrome accompanied by several benign or malignant tumors, including cystic tumors, in various organs. We describe here a long-term survival case who underwent surgical resection for metachronous liver metastases of pancreatic SCN associated with VHL disease.

Case presentation
A 35-year-old woman with VHL underwent total pancreatectomy and right nephrectomy for pancreatic SCN and renal cell carcinoma, respectively. At the 4th year follow-up examination after the resection, contrast-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) showed arterially hyper-enhanced neoplastic lesions in the segment VI and VIII of the liver. Partial resections of the liver were performed 53 months after the initial surgery. At the 6th month follow-up examination from the second surgery, one and two tumors located in the liver segment III, and VIII, respectively, were detected by contrast-enhanced CT and Gd-EOB-DTPA-enhanced MRI. Anterior segmentectomy and partial resection of the segment III were performed 66 months after the initial surgery and 13 months after the second, respectively. The tumors were pathologically diagnosed as liver metastases of pancreatic SCN synonymous with serous cystadenocarcinoma. She remains disease-free without recurrence 6.5 years after the last operation.

Conclusions
This is the first report of a case of metastatic SCN associated with VHL. Surgical resection might confer a favorable prognosis in patients of pancreatic SCN with liver metastases.
The impact of mediated learning on the academic writing performance of medical students in flipped and traditional classrooms: scaffolding techniques
Authors: Khojasteh Laleh , Hosseini Seyyed Ali , Nasiri Elham 
Published: June 2021

AbstractWriting as a multiple-step process is one of the most complex and demanding skills for graduate students to master. Foreign or second language learners who are required to write for academic purposes at the university level may even find it more demanding to master. One of the ways of decreasing the burden of mastering this skill for learners is mediation, using scaffolding techniques to teach writing. Hence, having a good understanding of the impact(s) of adopting mediating or scaffolding techniques in writing classes is absolutely indispensable. To this end, the present study employed an experimental research design to investigate the impact of mediation in the flipped writing classrooms of the students of medicine. To peruse this goal, 47 medical students were selected through purposive sampling and put into control and treatment groups. Medical students in the treatment group watched teacher-made video content(s) before their writing classes. The students in this group experienced organized-interactive writing group activities in their classes. Unlike the experimental group, the students in the control group received all the instructions in the classroom and were assigned homework. The findings obtained through the ANOVA and t-test indicated that the students in the experimental group significantly outperformed their counterparts in the control group in terms of their writing. A probable conclusion could be that by requiring students to study in advance and take responsibility for their learning, flipped classroom can provide the opportunity for learners to actively construct knowledge rather than receive the information passively in the classroom. Flipped classroom can also cultivate interactive class time for teachers and enable them to invest in more fruitful academic practices, instead of asking students to spend a substantial amount of time each week doing homework independently.
Does Covera-19 know ‘when to hold ‘em or ‘when to fold ‘em? A translational thought experiment
Authors: Griffin Gerald Dieter 
Published: June 2021

AbstractThe function of proteins depends on their structure. The structural integrity of proteins is dynamic and depends on interacting nearby neighboring moieties that influence their properties and induce folding and structural changes. The conformational changes induced by these nearby neighbors in the micro-environmental milieu at that moment are guided by chemical or electrical bonding attractions.There are few literature references that describe the potential for environmental milieu changes to disfavor SARS-CoV-2 attachment to a receptor for survival outside of a host. There are many studies on the effects of pH (acid and base balance) supporting its importance for protein structure and function, but few focus on pH role in extracellular or intracellular protein or actionable requirements of Covera-19.‘Fold ‘em or Hold ‘em’ is seen by the various functions and effects of furin as it seeks an acidic milieu for action or compatible amino acid sequences which is currently aided by its histidine component and the structural changes of proteins as they enter or exit the host. Questions throughout the text are posed to focus on current thoughts as reviewing applicable COVID-19 translational research science in order to understand the complexities of Covid-19.The pH needs of COVID-19 players and its journey through the human host and environment as well as some efficacious readily available repurposed drugs and out-of-the box and easily available treatments are reviewed.
How precise are oral splints for frameless stereotaxy in guided ear, nose, throat, and maxillofacial surgery: a cadaver study
Authors: Nilius Manfred , Nilius Minou Hélène 
Published: June 2021

Abstract
Background
Computer-assisted surgery optimises accuracy and serves to improve precise surgical procedures. We validated oral splints with fiducial markers by testing them against rigid bone markers.

Methods
We screwed twenty bone anchors as fiducial markers into different regions of a dried skull and measured the distances. After computed tomography (CT) scanning, the accuracy was evaluated by determining the markers’ position using frameless stereotaxy on a dry cadaver and indicated on the CT scan. We compared the accuracy of chairside fabricated oral splints to standard registration with bone markers immediately after fabrication and after a ten-time use. Accuracy was calculated as deviation (mean ± standard deviation). For statistical analysis, t test, Kruskal-Wallis, Tukey's, and various linear regression models, such as the Pearson's product–moment correlation coefficient, were used.

Results
Oral splints showed an accuracy of 0.90 mm ± 0.27 for viscerocranium, 1.10 mm ± 0.39 for skull base, and 1.45 mm ± 0.59 for neurocranium. We found an accuracy of less than 2 mm for both splints for a distance of up to 152 mm. The accuracy persisted even after ten times removing and reattaching the splints.

Conclusions
Oral splints offer a non-invasive indicator to improve the accuracy of image-guided surgery. The precision is dependent on the distance to the target. Up to 150-mm distance, a precision of fewer than 2 mm is possible. Dental splints provide sufficient accuracy than bone markers and may opt for higher precision combined with other non-invasive registration methods.
Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine
Authors: Datta-Chaudhuri Timir 
Published: June 2021

AbstractMouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of tools for chronic stimulation and sensing. A wireless neuromodulation platform small enough for implantation in mice will significantly increase the utility of mouse models in bioelectronic medicine. This perspective examines the necessary functionality of such a system and the technical challenges needed to be overcome for its development. Recent progress is examined and the outlook for the future of implantable devices for mice is discussed.
What Matters to Us: Impact of Telemedicine During the Pandemic in the Care of Patients With Sarcoma Across Scotland
Authors: McCabe Holly M. , Smrke Alannah , Cowie Fiona , White Jeff , Chong Peter , Lo Steven , Mahendra Ashish , Gupta Sanjay , Ferguson Michelle , Boddie David , Mmekka Walter , Stirling Lorraine , Campbell Lindsay , Jones Robin L. , Nixon Ioanna 
Published: June 2021

PURPOSE In Scotland, approximately 350 sarcoma cases are diagnosed per year and treated in one of the five specialist centers. Many patients are required to travel long distances to access specialist care. The COVID-19 pandemic brought a number of rapid changes into the care for patients with cancer, with increasing utilization of telemedicine. We aimed to evaluate how the utilization of telemedicine affects professionals and patients across Scotland and care delivery, at the Beatson West of Scotland Cancer Centre Sarcoma Unit. METHODS Between June 8 and August 25, 2020, we invited patients and professional sarcoma multidisciplinary team members to participate in separate online anonymous survey questionnaires, to assess their attitudes toward telemedicine. Data were extracted, and descriptive statistics were performed. RESULTS Patient satisfaction (n = 64) with telemedicine was high (mean = 9.4/10) and comparable with traditional face-to-face appointments (mean = 9.5/10). Patients were receptive to the use of telemedicine in certain situations, with patients strongly opposed to being told bad news via telemedicine (88%). Providers recommended the use of telemedicine in certain patient populations and reported largely equivalent workloads when compared with traditional consultations. Providers reported that telemedicine should be integrated into regular practice (66%), with patients echoing this indicating a preference for a majority of telemedicine appointments (57%). CONCLUSION Telemedicine in sarcoma care is favorable from both clinician and patient perspectives. Utilization of telemedicine for patients with rare cancers such as sarcomas is an innovative approach to the delivery of care, especially considering the time and financial pressures on patients who often live a distance away from specialist centers. Patients and providers are keen to move toward a more flexible, mixed system of care.
A Serum Resistin and Multicytokine Inflammatory Pathway Is Linked With and Helps Predict All-cause Death in Diabetes
Authors: Scarale Maria Giovanna , Antonucci Alessandra , Cardellini Marina , Copetti Massimiliano , Salvemini Lucia , Menghini Rossella , Mazza Tommaso , Casagrande Viviana , Ferrazza Gianluigi , Lamacchia Olga , De Cosmo Salvatore , Di Paola Rosa , Federici Massimo , Trischitta Vincenzo , Menzaghi Claudia 
Published: June 2021

Abstract

Context
Type 2 diabetes (T2D) shows a high mortality rate, partly mediated by atherosclerotic plaque instability. Discovering novel biomarkers may help identify high-risk patients who would benefit from more aggressive and specific managements. We recently described a serum resistin and multicytokine inflammatory pathway (REMAP), including resistin, interleukin (IL)-1β, IL-6, IL-8, and TNF-α, that is associated with cardiovascular disease.

Objective
We investigated whether REMAP is associated with and improves the prediction of mortality in T2D.

Methods
A REMAP score was investigated in 3 cohorts comprising 1528 patients with T2D (409 incident deaths) and in 59 patients who underwent carotid endarterectomy (CEA; 24 deaths). Plaques were classified as unstable/stable according to the modified American Heart Association atherosclerosis classification.

Results
REMAP was associated with all-cause mortality in each cohort and in all 1528 individuals (fully adjusted hazard ratio [HR] for 1 SD increase = 1.34, P &lt; .001). In CEA patients, REMAP was associated with mortality (HR = 1.64, P = .04) and a modest change was observed when plaque stability was taken into account (HR = 1.58; P = .07). REMAP improved discrimination and reclassification measures of both Estimation of Mortality Risk in Type 2 Diabetic Patients and Risk Equations for Complications of Type 2 Diabetes, well-established prediction models of mortality in T2D (P &lt; .05-&lt; .001).

Conclusion
REMAP is independently associated with and improves predict all-cause mortality in T2D; it can therefore be used to identify high-risk individuals to be targeted with more aggressive management. Whether REMAP can also identify patients who are more responsive to IL-6 and IL-1β monoclonal antibodies that reduce cardiovascular burden and total mortality is an intriguing possibility to be tested.