bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of efficacy and safety of Qiangzhu-qinggan formula as an adjunctive therapy in adult patients with severe influenza: study protocol for a randomized parallel placebo-controlled double-blind multicenter trial
Authors: Qiu Lei , WU Xianwei , Zhang Shaoyan , Yang Ming , Zhang Shunxian , Fu Jiyou , Li Cui , Zhang Zhijie , Zheng Peiyong , LU Zhenhui 
Published: June 2021

Abstract
Background: Influenza can fall into three categories according to severity: mild influenza, severe influenza, and critical influenza. Severe influenza can result in critical illness and sometimes death particularly in patients with comorbidities, advanced age, or pregnancy. Neuraminidase inhibitors (NAIs) are the only antiviral drugs in widespread use for influenza. However, the effectiveness of NAIs against severe influenza is uncertain. New effective drugs or regimens are therefore urgently needed. Qiangzhu-qinggan (QZQG) formula has been found to be effective against influenza virus infection during long-term application in China, which lacks support of evidence-based clinical trial till now. This study is designed to assess the efficacy and safety of QZQG formula as an adjuvant therapy in adult patients with severe influenza. Methods: This protocol is drawn up in accordance with the SPIRIT guidelines and CONSORT Extension for Chinese herbal medicine formulas. This is a randomized, placebo-controlled, double-blind, multicenter trial. 228 adults with severe influenza are randomly assigned in a 1:1 ratio to QZQG or placebo for 7 days and receive 1 day of screening, 7 days of intervention and 21 days of observation. The primary outcome is the proportion of clinical improvement, defined as the proportion of patients who met the criteria of 3 points or less in the seven-category ordinal scale or 2 points or less in National Early Warning Score 2 within 7 days after randomization. Discussion: This is the first randomized, controlled, parallel, double-blind clinical trial to evaluate the efficacy and safety of traditional Chinese herbal formula granules as an adjuvant therapy in adult patients with severe influenza. This study aims to redefine the value of traditional Chinese herbal medicines in the treatment of virus-related respiratory infectious diseases and serves as an example of evidence-based clinical trials of other Chinese herbal medicines.
Efficacy and Safety of Jin-Shui Huan-Xian Granule for Idiopathic Pulmonary Fibrosis: Study Protocol for a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Yang Shu-guang , Yu Xue-qing , Li Jiansheng , Xie Yang , Zhang Wei , Ban Chengjun , Feng Jihong , Wu Lei , Lu Xuechao , Zhao Linmin , Meng Yong , Zhou Miao , He Yong , Luo Weixian 
Published: June 2021

Abstract
Background

Idiopathic pulmonary fibrosis is a critical disease with poor prognosis. Although different studies have been conducted for the treatment of idiopathic pulmonary fibrosis, limited treatments are available. Jin-shui Huan-xian granule, which is a Chinese medicine herbal compound, has shown a promising efficacy in reducing frequencies of acute exacerbations, improving exercise capacity the quality of life of patients for idiopathic pulmonary fibrosis.
Subjects and Methods:

This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 312 idiopathic pulmonary fibrosis patients will be enrolled and randomly allocated to one of the two groups with 1:1. After a 2-week washout period, 52-week treatment will also be performed for all the patients. Patients in experimental group will be given Jin-shui Huan-xian granule with Jin-shui Huan-xian placebo for control group. Outcome measures including acute exacerbations, pulmonary function, dyspnea, exercise capacity, quality of life will be evaluated in this study.
Discussion

Based on our previous study, it is hypothesized that JHG will reduce the acute exacerbations, improve exercise capacity, pulmonary function, quality of life, delay the disease progression-free. High-level evidence-based support for TCM in IPF will also be obtained in this study.
Trial registration:
http:www.clinicaltrials.gov : NCT04187690. Register data: December 11, 2019.
Design,Simulation And Analysis of Junction Version Multi-Fin FINFET
Authors: K Srinivasa Rao , P Vishnu Vandana 
Published: June 2021

Abstract
This paper presents a 3-D statistical simulation study of Multi-fin junction FinFET for different technology nodes 32nm, 24 nm & 10 nm. For each and every technology node their corresponding Electrical parameters like on current (Ion), off current (Ioff), threshold voltage (Vth) are reported in the paper and also RF/Analog parameters like transconductance (gm), output conductance (gd), intrinsic gain (gm/gd) are reported. And also parameters like Electric field (E), Electron density (ne), Electron mobility (µ) which are measured across the device length are simulated. The proposed structure showed performance improvement in all the parameters when the technology node is decreased.
Evaluation of the Intensive Treatment and Rehabilitation Program for Residential Treatment and Rehabilitation Centers (INTREPRET) in the Philippines: A Study Protocol for a Randomized Controlled Trial
Authors: Harada Takayuki , Baba Toshiaki , Shirasaka Tomohiro , Kanamori Shogo 
Published: June 2021

Abstract
Background: The Philippines is one of the most severely affected countries by the methamphetamine epidemic in the world. The government launched a war on drugs policy to counter the situation in the country. However, brutality against drug users was criticized internationally. Thus, we have developed a comprehensive treatment program for methamphetamine users based on cognitive-behavioral therapy (CBT) and are going to evaluate its effectiveness. If its effectiveness is demonstrated, it will be helpful to implement much more effective and humane approaches to drug issues in the Philippines.Methods: Methamphetamine users who are admitted to government-run rehabilitation facilities are recruited and are randomly assigned either to the CBT-based treatment program or existing therapeutic community (TC)-based treatment. The CBT treatment program was developed based on the Matrix model considering the cultural and social factors in the Philippines. After 6-months treatment, participants will be followed up for 3 months and drug use (urine testing) and other psychological variables including craving, coping skills, and well-being will be compared.Ethics and dissemination Informed consent will be obtained from study participants prior to study participation. Ethical approval was obtained from research ethics review boards in both countries. This study was approved by Single Joint Research Ethics Board of the Department of Health, Republic of the Philippines (SJREB-2019-27) and the University of Tsukuba Faculty of Human Sciences Ethics Committee (T2019-70). 1). Potential participants will be given a summary of the study and a consent form. The consent form is signed and dated by participants prior to their study participation. Findings of this study will be submitted for publication in international scientific peer-reviewed journals and be presented at academic conferences.Trial registration number: UMIN Clinical Trials Registry JPRN-UMIN000038597. Registered on 15 November 2019. Protocol version February 13, 2020 ver.1
The Immediate And Long-Term Effects of Shexiang Tongxin Dropping Pill On Coronary Slow Flow: Study Protocol For A Randomized Double-Blind Placebo-Controlled Trial
Authors: Liu Birong , Liu Yong , Ma Liyong , Liu Jia , Li Jingen , Huang Kailin , Fu Qiang , Zheng Xiangying , Pan Yi , Zhang Wei , Gao Qun , Ye Jiaqi , Liu Yuqing , Hao Xuezeng , Li Meng , Zhang Lijing 
Published: June 2021

Abstract
Background: Coronary slow flow (CSF) is a phenomenon characterized by delayed contrast medium progression in angiography in the absence of obstructive coronary epicardial disease. However, there is currently no definite effective therapy. A small sample self-controlled study had suggested an immediate improvement in coronary slow blood flow by Shexiang Tongxin Dropping Pills (STDP). But high-quality evidences on drug dosage, medication cycle and long-term effects are still lacking while the mechanism of STDP remains unclear. Methods: This study is a randomized, double-blinded, and placebo-controlled clinical trial. A total of 64 CSF patients diagnosed by coronary angiography will be randomly allocated into the test group, using STDP, and the control group, using placebo. The main efficacy indicators for immediate effects include thrombolysis in myocardial infarction (TIMI) blood flow grading and corrected TIMI frame count. Long-term effects will be evaluated by the comparison of cardiac radionuclide score, and patient condition such as angina readmission rate and angina scale. The safety indicators include a routine complete blood count, liver and renal function test, cardiac markers (including TnI, CK-MB, Myo), NT-proBNP, coagulation function, 12-lead electrocardiogram, and echocardiography. All adverse events during the trial will be recorded. Moreover, endothelial factors (including ET-1, NO, eNOS, iNOS), inflammatory factors (including adropin, IL-6, IL-1, IL-18, TNF-α, Lp-PLA2, hs-CRP) will be observed. Blood stasis syndrome (including platelet activation factors such as CD62 and CD63, coagulation function and blood stasis syndrome score) will be evaluated.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000035167. Registered on August 2, 2020. http://www.chictr.org.cn/showproj.aspx?proj=57349
Remote TSN Frame Encapsulation by means of FPGA
Authors: Jiménez Jaime , Rodríguez Igor , Reguilón David , Zuloaga Aitzol , Lázaro Jesús 
Published: June 2021

Abstract
TSN (Time-Sensitive Networking) has replaced outdated Fieldbus and non-deterministic Ethernet in the Industry 4.0. Field buses are not capable of providing neither connection for industry 4.0 IoT (Internet of Things) nor compatibility between different manufacturers. On the other hand, Ethernet is not able to ensure real-time. On the contrary, TSN guarantees real-time transmission, IoT and compatibility between devices. However, adapting to frequently changing needs makes TSN protocol evolve continuously. For this reason, devices for TSN analysis, such as PCs or not advanced frame analysis equipment are not able to process TSN packets at the speed that standard advances, discarding them as wrong frames. The integration of a System on Chip (SoC) that contains an FPGA (Field Programmable Gate Array) and a microcontroller, with capacity for reconfiguration and monitoring of the frames in the protocol, would be an ideal solution to this problem. This paper describes how to encapsulate TSN frames in Ethernet packets using an FPGA. Such Ethernet frames can subsequently be decapsulated, i.e. in a PC, and thus enable analysing TSN traffic in nonspecialized devices.
Joint Channel Assignment and Bandwidth Reservation using Improved FireFly Algorithm (IFA) in WMN
Authors: narayanarao narayanarao , Reddy A. Rajasekhar 
Published: June 2021

Abstract
In WMN, at the time of network consignment and bandwidth registration, the active network consignment method did not take into consideration the intrusion, congestion load and bandwidth necessities as a whole. The significance centred bandwidth registration methods result in famishment of slightest significance congestion. Hence in this paper, we propose a Joint Channel Assignment and Bandwidth Reservation using Improved FireFly Algorithm (IFA) in WMN. Initially the priority of each node is determined based on the channel usage, future interference and link congestion probability metrics. The bandwidth is allocated straight, comparative to the nodule significance and entire quantity of congestion movements incomplete on the demanded nodule. For channel assignment and path selection, the improved FireFly Algorithm (IFA) is used. The objective function of IFA is determined in terms of link capacity, interference and flow conservation constraints. Then the channels and the path which minimize the objective function are selected by applying IFA. By simulation results we show that the proposed technique minimizes the traffic and enhances the channel efficiency.
Does the Sensitivity of Intravenous Anesthetic of Remimazolam Increase in Patients With Obstructive Jaundice?
Authors: song jinchao , Liu Wen , Ji Jun-Wei , Tao Kun-Ming , Qiu Hai-Bo , Song Hong-Hao , Song Jin-Chao 
Published: June 2021

Abstract
BackgroundIt is well known that obstructive jaundice could affect the pharmacodynamics of some anesthetics, and the sensitivity of some anesthetics would increase among icteric patients. Remimazolam is a new ultra-short-acting intravenous benzodiazepine sedative/anesthetic, which is a high-selective and affinity ligand for the benzodiazepine site on the GABAA receptor. However, very few studies have been reported the pharmacodynamics of remimazolam in patients with obstructive jaundice. We hypothesize that obstructive jaundice affects the pharmacodynamics of remimazolam, and the sensitivity of remimazolam increases among icteric patients.Methods/designThe study will be performed as a prospective, controlled, multicenter trial. The study design is a comparison of remimazolam requirements to reach a Bispectral Index of 50 in patients with obstructive jaundice versus non-jaundiced patients with chronic cholecystitisor intrahepatic bile duct stones. Remimazolam was infused at 0.03 mg/kg/min until this end point was reached.DiscussionRemimazolam could be suitable for anesthesia of patients with obstructive jaundice, because remimazolam is not biotransformed in the liver. Hyperbilirubinemia has been well-described toxic effects in the brain, which causes the increasing of sensitivity to some anesthetics, such as desflurane, isoflurane and etomidate. Furthmore, remimazolam and etomidate have the same mechanism of action when exerting an anesthetic effect. We aim to demonstrate that obstructive jaundice affects the pharmacodynamics of remimazolam, and the dose of remimazolam when administered to patients with obstructive jaundice should be modified.Trial registrationChinese Clinical Trial Registry ChiCTR2100043585. Date of registration: February 23, 2021.
Pressure Dressings Versus Nonpressure Dressings After Hemorrhoidectomy: Study Protocol for a Randomized Controlled Trial
Authors: Xue Ping , Wu Jing , Zhu Ping , Wang Dan , Xu Mei , Zhang Yi , Lu Guanmao , Chen Quanyi , Zhang Qin , Tang Renjing , Fang Jinbo 
Published: June 2021

Abstract
BackgroundPressure dressings have been used after open hemorrhoidectomy to protect surgical wounds and manage postoperative bleeding for many years. However, pressure dressings may increase the incidence of postoperative complications, such as urinary retention, medical adhesive-related skin injury, and pain. A previous controlled trial included 67 patients who underwent Milligan-Morgan hemorrhoidectomy. The data indicated that the use of a nonpressure dressing after hemorrhoidectomy reduces the incidence of urinary retention and catheterization. However, the incidence of severe postoperative bleeding and other postoperative complications was not assessed. There is no consensus on whether it is necessary and beneficial to use a nonpressure dressing after hemorrhoidectomy. The results of this randomized clinical study will help answer this question.MethodsIn this study, we plan to include 186 patients who have undergone Milligan-Morgan hemorrhoidectomy. The purpose is to determine whether the use of nonpressure dressings after open hemorrhoidectomy is inferior to the use of pressure dressings in terms of severe postoperative bleeding and postoperative complications. The primary endpoints of the trial are the incidence of urinary retention within 24 hours after surgery and the incidence of severe postoperative bleeding one hour after dressing removal, which requires revision surgery within 24 hours after the surgery. The secondary endpoints of the study are the pain score, anal distension score, postoperative use of analgesics, and incidence of medical adhesive-related skin injury, all of which will be assessed before removing the dressings. The length of hospitalization in days and hospitalization expenses will be recorded. Safety will be assessed with consideration of all adverse and severe adverse events related to the study treatment.DiscussionThe study received full ethics committee approval. The first patient was enrolled on 27 November 2020. The results of this trial will finally answer the question of whether a nonpressure dressing after open hemorrhoidectomy is necessary and beneficial.Trial registrationChinese Clinical Trial Registry (registration ID: ChiCTR2000040283). Registered on 28 November. 2020. {2} http://www.chictr.org.cn/edit.aspx?pid=58894&htm=4 {2b}
The Role of Ni and Cd-Resistant Rhizobacteria in Promotion of Rice Seedlings Growth and Alleviation Combined Phytotoxicity of Ni and Cd
Authors: Xiao Weiwei , Ji Jing , Guan Chunfeng , Zhang Songhao , Zhang Siqi , Wang Gang , Wang Yurong , Zhang Hongzhi 
Published: June 2021

Abstract
The heavy metal compound pollution is becoming a serious problem in the environmental management. In the present study, we focused on the combined pollution of nickel (Ni) and cadmium (Cd) and isolated three Ni and Cd-resistant rhizobacteria (strains Y3, Y4 and Y5) with important PGP traits. According to 16S rDNA sequence homology, strains Y3, Y4 and Y5 were identified as Pseudomonas sp., Chryseobacterium sp. and Enterobacter sp., respectively. Then the effects of strains Y3, Y4 and Y5 on rice growth under the combined stress of Ni and Cd were examined. The results indicated that strains Y3, Y4 and Y5 enhanced the seed germination, biomass production and chlorophyll accumulation of rice seedling under compound stress of Ni and Cd. These strains also conferred rice tolerance to Ni and Cd by increasing antioxidant enzyme activity in seedlings. Furthermore, comparing among three strains, it was found that strain Y3 with stronger ability of IAA production, EPS production and ACC deaminase activity had the best promotion effect on rice growth under the combined stress of Ni and Cd. In addition, strain Y5 had better IAA production capacity and a better effect on the growth of rice roots than strain Y4 under Ni and Cd stress, which indicated that IAA production might play a particularly critical role in root growth under the stress of Ni and Cd.
Herbs of rich-Iodine for Graves’ Hyperthyroidism Trial (the HIGHT trial): a study protocol for a randomized, double-blind, placebo-controlled, multicentre clinical trial
Authors: Gao Chenghan , Liu Xiaowei , Guan Xuefeng , Liu Qingyang , Lai Yiwen , Gao Tianshu 
Published: June 2021

Abstract
BackgroundGraves' hyperthyroidism is one of the refractory diseases in endocrinology. Thionamides are known to be effective and its common side-effects are markedly reduced when starting with low dose. Iodine-rich Chinese herbal decoction (IRH) is a frequently prescribed Chinese herbal medicine in patients with Graves' hyperthyroidism. However, high quality clinical evidence is still very scarce, which made the Traditional Chinese Medical (TCM) management of Graves' hyperthyroidism remains controversial. The objective of this study is to prove that IRH might get faster and longer lasting remission and improved quality of life (QoL) in Graves' hyperthyroidism patients compared with methimazole (MMI) .Methods/designThis study is a randomized, double-blind, placebo-controlled and multicentre clinical trial. We will recruit a total of 240 participants with Graves' hyperthyroidism who have any common ATD-associated side-effects. They will be randomized (1:1:1) to receive (ⅰ) IRH plus MMI placebo, (ⅱ) IRH placebo plus MMI and (ⅲ) IRH plus MMI for 12 weeks. The primary outcome measures will be the serum free triiodothyronine (FT3), free thyroxine (FT4) levels and serum thyroid-stimulating hormone (TSH) level. Secondary outcome measures will include the level of thyroid stimulating hormone-receptor antibodies (TRAb), thyroid ultrasound (US) and Thyroid-specific Patient Reported Outcome(ThyPRO39).DiscussionThe outcomes of this study will provide new evidence for the efficacy and safety of IRH for the treatment of Graves' hyperthyroidism and will also guide physicians at clinics more clearly in prescribing IRH.Trial registration number:ChiCTR, ChiCTR2000032706. Registered 7 May 2020, http://www.chictr.org.cn
U19-Net: A Deep Learning Approach for Obstacle Detection in Self-Driving Cars
Authors: Cervera-Uribe Albert Aarón , Mendez-Monroy Paul Erick 
Published: June 2021

Abstract
Development of self-driving cars aims to drive safely from one point to another in a coordinated system where the on-board autonomous vehicle system should react and possibly alert drivers about the driving environments and possible collisions that may arise between drivers and obstacles. In order to achieve a high level of autonomy in urban scenarios with unpredictable traffic, these systems must have robust and reliable obstacles detection systems.
This work proposes U19-Net, a deep learning model that explores improvement of the so-called encoder-decoder neural networks with a very deep network architecture. In particular, U19-Net is applied and successfully evaluated for the vehicle and pedestrian detection tasks within an open source dataset consisting of frames from a video in real driving scenarios. The output of the network consists of a pixel-level mask that identifies each pixel as vehicle or pedestrian, demonstrating that the depth representation attained with U19-Net is beneficial in this kind of architecture for vision systems in self-driving cars.
On the Brink of Extinction: A New Freshwater Amphipod Jesogammarus Acalceolus (Anisogammaridae) From Japan
Authors: Tomikawa Ko , Kimura Naoya 
Published: June 2021

Abstract
Freshwater habitats, especially cold springs, are environments in which the extinction risk faced by organisms remains high due to human activities. The extinction risks faced by many species go unrecognized prior to their extinction. To conserve endangered species, it is important to describe and name them. Here, we describe a new, endangered freshwater anisogammarid amphipod species, Jesogammarus (Jesogammarus) acalceolus sp. nov., found in a spring in Aomori Prefecture, Japan, which is potentially the sole remaining habitat of this species. Both morphological and molecular phylogenetic results strongly support the nesting of the new species within Jesogammarus. Jesogammarus (J.) acalceolus sp. nov. is the first species of genus Jesogammarus that was found to lack a calceolus, a sensory organ located on male antenna 2. Thus, the diagnostic criteria for this genus required amendment. A reconstruction of ancestral calceoli, based on a molecular phylogenetic tree, revealed that the common ancestor of Jesogammarus possessed calceoli, which were secondarily lost in J. (J.) acalceolus sp. nov. Our results indicate that this new species, which is key to clarifying the evolution of the calceolus, is of high conservation significance.
Size- and Temperature-control Optical Direct/indirect Band Tuning in Layered Compounds: Band Gap Engineering
Authors: Miah M. 
Published: June 2021

Abstract
The X-ray diffraction (XRD) is studied in thermally evaporated cadmium iodide (CdI2) thin films with various thicknesses. The grain size, calculated from the XRD, is found to increase with increasing the thickness of the film, while the reflectivity and refractive index decease with increasing the wavelength of the exciting light. The optical absorption spectra show both allowed direct and indirect interband transitions across a fundamental gap in CdI2. It is found that both indirect and direct band gap (Eg) decrease with increasing the thickness of the film and that the indirect Eg is lower than the direct Eg by an amount of about 0.7 eV. The direct Eg is also decreased with increasing both the grain size and temperature. However, the temperature dependence of Eg follows the Varshni relation. Our results highlight the possibility of engineering or tuning the Eg of CdI2 by controlling the thickness of the film, grain size as well as temperature.