bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYNCHRONOUS AND ASYNCHRONOUS WITH FLIPPED LEARNING ENVIRONMENT IN PRIMARY SCHOOL
Authors: Rindaningsih Ida , Findawati Yulian , Hastuti Wiwik Dwi , Fahyuni Eni Fariyatul 
Published: March 2021

The challenges of learning during the pandemic are currently a big task for the world of education. The unpreparedness of school institutions, students, and parents in facing changes in the distance learning system has an impact on the implementation of learning during the COVID-19 pandemic. For this reason, it is necessary to have a learning solution that can answer the challenges of learning using digital-based learning. This research aims to develop a model of the reverse learning environment. This development research examines various aspects of the needs of the student learning environment during the COVID-19 pandemic. The subjects of this study were school principals, deputy principals, and elementary school teachers who have implemented the 2013 Curriculum. The results of this study show that the synchronous and asynchronous framework with the reverse learning environment approach is proven valid and feasible applied to learning COVID-19. The findings synchronous, and asynchronous that are implemented efficiently by the teacher, and applications will continue to be developed.
Angkutan Sedimen Menggunakan Metode Yang Pada Sungai Sombe, Palu, Sulawesi Tengah
Authors: Pratama M.I. 
Published: March 2021

The sedimentation process that occurs in in Sombe River is a phenomenon of sediment grainsor particles entrained from the riverbank avalanche. The problem is exacerbated when there is moderate to high intensity rainfall, causing sediment material transported by a flood. The purpose of this study is to identify and estimate the amount of sediment transport in Sombe River. In this research, direct measurements were carried out by taking sediment samples from the Sombe River, furthermore it is also used secondary data such as rainfall data and data characteristics of the watershed. The results of the analysis using the Yang method show that the average value of sediment transport in the Sombe River with a return period of 1 year, 2 years, 5 years and 10 years is 5.7x106 - 7.5x106 tons / year.
TANGGUNG JAWAB GURU SEKOLAH MINGGU DALAM KEHIDUPAN SPIRITUAL ANAK
Authors: Bawole Susan 
Published: March 2021

Tugas dan tanggung jawab Guru sekolah minggu sangatlah berat di zaman yang semakin maju, guru sekolah minggu mempunyai peran yang penting dalam perkambangan spiritual anak di masa ini. Guru sebagai alat Tuhan untuk mendidik anak dalam lingkup gereja. Namun tidak begitu baik adanya di karenakan banyak guru yang melalaikan Tugasnya untuk melayani anak-anak. banyak guru hanya sekedar datang tapi tidak melakukan tanggung jawabnya dengan benar, tidak mempunyai persiapan yang matang. Guru sebegai ujung tombak dalam mengajar anak jika tidak melaksanakan Tugas dengan baik, akan di pastikan tidak ada lagi anak-anak yang akan datang ke gereja di masa yang datang. Jurnal ini mempunyai tujuan untuk memberikan informasi bagaimana sesungguhnya Tugas dari guru sekolah minggu dalam pembentukan spiritual anak.
In vitro: The Modulating Effect of Myricetin on the Atherosclerosis Related Processes in THP1 Macrophages
Authors: Almassabi Rehab F. , Huwait Etimad A. , Almowallad Sanaa J. , Saddeek Salma Y. , Gauthaman Kalamegam 
Published: March 2021

Aims: To assess the anti-atherosclerotic effects of Myricetin (pharmaceutical) in human THP-1 macrophages following IFN-γ or MCP-1 stimulation.
Study Design: The protective effects of myricetin against atherosclerosis was evaluated using the humanTHP-1 macrophages and studying the following parameters namely, cell viability, cell proliferation, cell migration, inflammation related gene expression and cholesterol efflux in vitro.
Place and Duration of Study: THP-1 cell line: Department of biochemistry (faculty of science), Cell Culture Unit, Experimental Biochemistry Unit (King Fahad Medical Research Centre), King Abdul Aziz University, between September 2019 and September 2020.
Methodology: The THP-1 cell lines were differentiated into macrophages by incubation with PMA (160 nM) for 24 hours. The viability percentage was determined using Pierce LDH cytotoxicity assay kit, the percentage change in macrophages proliferation was evaluated by crystal violet dye, the RNA was extracted then the cDNA was synthesized and the quantitative real time polymerase chain reaction (qRT-PCR) was done for inflammation-related genes, ICAM-1 and MCP-1. The percentage of monocyte migration and cholesterol efflux were also calculated.
Results: Cytotoxicity assays demonstrated no significant toxicity with myricetin at 25μM and 50 μM concentrations on THP-1 macrophages. The quantitative real-time RT-PCR (qRT-PCR) demonstrated a significant increase in interferon gamma (IFN-γ) mediated expression of both intercellular adhesion molecule (ICAM-1) and monocyte chemo-attractant protein-1 (MCP-1) by 2.1 and 7.1 fold respectively, compared to the control. Treatment with myricetin (25 μM and 50 μM) significantly inhibited the IFN-γ induced overexpression of ICAM-1 by 42.86% & 71.34% and MCP-1 by 53.52% & 87.32% respectively. Myricetin (25 μM) significantly reduced the migration of monocytes by 33.66% compared to MCP-1. The cholesterol efflux from THP-1 macrophages treated with myricetin was significantly increased by 47% and 57% in the absence and presence of IFN-γ, respectively compared to the control.
Conclusion: Myricetin has anti-inflammatory effects and supports cholesterol efflux, which can help in prevention of atherosclerosis. Furthermore, myricetin did not exhibit any cytotoxic effects and therefore is a safe phytochemical which can complement conventional therapeutics.
Promenade of wind ‐NIFCO YRP‐
Authors: Koshino Tatsuya , Tai Toru 
Published: March 2021

AbstractThe Promenade of Wind is an entry building to experimental facilities on a nature‐rich hill where a fresh prevailing wind blows. The building provides an open passage space connecting the buildings standing on its 2 sides, and is used as a thinking, resting, communication, and meeting space for researchers. The big yajirobe (balancing‐toy) roof framed structure provides a variety of places to stay. We have created a space that makes you feel more familiar with natural changes by positively taking in “variations in environment”, such as changes in light and wind, through water features and natural ventilation.
Printed Iontophoretic‐Integrated Wearable Microfluidic Sweat‐Sensing Patch for On‐Demand Point‐Of‐Care Sweat Analysis
Authors: Paul Brince , Demuru Silvia , Lafaye Céline , Saubade Mathieu , Briand Danick 
Published: March 2021

AbstractIn recent years, wearable epidermal sweat sensors have received extensive attention owing to their great potential to provide personalized information on the health status of individuals at the molecular level. For on‐demand medical analysis of sweat in sedentary conditions, a cost‐effective wearable integrated platform combining sweat stimulation, sampling, transport, and analysis is highly desirable. In this work, a printed iontophoretic system integrated into a microfluidic sensing platform, which combines sweat induction, collection, and real‐time analysis of sweat‐ions into a single patch for on‐demand sweat monitoring on human subjects in stationary conditions is reported. The incorporation of microfluidics features facilitates sweat sampling, collection, and guiding through capillary effect. The multisensing sensor array exhibits sensitivity close to Nernstian behavior for sodium, potassium, and pH. The correlation between the concentrations of ions measured with the sweat patch and with ion chromatography analysis demonstrates the applicability of the system for real‐time point‐of‐care monitoring of the health status of individuals. Furthermore, the sweat patch electronic interface with wireless transmission enables real‐time data monitoring and storage over a cloud platform. This printed iontophoretic‐integrated fluidic sweat patch provides a cost‐effective solution for the on‐demand analysis of sweat components for healthcare applications.
Recent Progress on Flexible Capacitive Pressure Sensors: From Design and Materials to Applications
Authors: Mishra Rishabh B. , El‐Atab Nazek , Hussain Aftab M. , Hussain Muhammad M. 
Published: March 2021

AbstractFor decades, the revolution in design and fabrication methodology of flexible capacitive pressure sensors using various inorganic/organic materials has significantly enhanced the field of flexible and wearable electronics with a wide range of applications in aerospace, automobiles, marine environment, robotics, healthcare, and consumer/portable electronics. Mathematical modelling, finite element simulations, and unique fabrication strategies are utilized to fabricate diverse shapes of diaphragms, shells, and cantilevers which function in normal, touch, or double touch modes, operation principles inspired from microelectromechanical systems (MEMS) based capacitive pressure sensing techniques. The capacitive pressure sensing technique detects changes in capacitance due to the deformation/deflection of a pressure sensitive mechanical element that alters the separation gap of the capacitor. Due to advancement in state‐of‐the‐art fabrication technologies, the performance and properties of capacitive pressure sensors are enhanced. In this review paper, recent progress in flexible capacitive pressure sensing techniques in terms of design, materials, and fabrication strategies is reported. The mechanics and fabrication steps of paper‐based low‐cost MEMS/flexible devices are also broadly reported. Lastly, the applications of flexible capacitive pressure sensors, challenges, and future perspectives are discussed.
Reversible Phase Transformations in Novel Ce‐Substituted Perovskite Oxide Composites for Solar Thermochemical Redox Splitting of CO2
Authors: Naik J. Madhusudhan , Ritter Clemens , Bulfin Brendan , Steinfeld Aldo , Erni Rolf , Patzke Greta R. 
Published: March 2021

AbstractThermochemical splitting of CO2 and H2O via two‐step metal oxide redox cycles offers a promising approach to produce solar fuels. Perovskite‐type oxides with the general formula ABO3 have recently gained attention as an attractive redox material alternative to the state‐of‐the‐art ceria, due to their high structural and thermodynamic tunability. A novel Ce‐substituted lanthanum strontium manganite perovskite‐oxide composite, La3+0.48Sr2+0.52(Ce4+0.06Mn3+0.79)O2.55 (LSC25M75) is introduced, aiming to bridge the gap between ceria and perovskite oxide‐based materials by overcoming their individual thermodynamic constraints. Thermochemical CO2 splitting redox cyclability of LSC25M75 evaluated with a thermogravimetric analyzer and an infrared furnace reactor over 100 consecutive redox cycles demonstrates a twofold higher conversion extent to CO than one of the best Mn‐based perovskite oxides, La0.60Sr0.40MnO3. Based on complementary in situ high temperature neutron, synchrotron X‐ray, and electron diffraction experiments, unprecedented structural and mechanistic insight is obtained into thermochemical perovskite oxide materials. A novel CO2 splitting reaction mechanism is presented, involving reversible temperature induced phase transitions from the n = 1 Ruddlesden–Popper phase (Sr1.10La0.64Ce0.26)MnO3.88 (I4/mmm, K2NiF4‐type) at reduction temperature (1350 °C) to the n = 2 Ruddlesden–Popper phase (Sr2.60La0.22Ce0.18)Mn2O6.6 (I4/mmm, Sr3Ti2O7‐type) at re‐oxidation temperature (1000 °C) after the CO2 splitting step.
A novel method for measuring dynamic contact angles of fibers with spindle‐knots
Authors: Aliabadi Maryam , Konrad Wilfried , Stegmaier Thomas , von Arnim Volkmar , Kaya Cigdem , Liu Yan , Zhan Bin , Wang Gouyong , Gresser Götz 
Published: March 2021

AbstractThe determination of the dynamic contact angle is of significant interest for the characterization of the wettability of technical fibers and textiles in diverse fields of science and technology. There exist traditional methods for dynamic contact angle measurements of flat surfaces and of fibers with a uniform cross‐sectional shape along the fiber. So far, however, no method has been reported which is suitable for structured fibers, particularly for spindle‐knotted structured fibers of varying cross‐sections. This article describes a new method for measuring the dynamic contact angle for polydimethylsiloxane (PDMS) spindle‐knotted structured fibers. The method is an outcome of integrating the results obtained from experiments (applying force tensiometry) and a proposed theoretical model describing such fibers. The reliability and conformity of the results are shown by comparing the measured dynamic contacts angle of PDMS as spindle‐knot and as a flat surface. This method may pave the road for better wettability analysis of various structured fibers. It also allows to measure the local receding and advancing contact angles for macroscopic/microscopic structured fibers (especially when they are not accessible as flat surfaces) against the various test liquids.
DFT Study on Dinuclear Palladium Complex Catalyzed Pyrrole Formation From tert‐Butyl Isocyanide and Alkynes
Authors: Lai Xiaoling , Li Yang 
Published: March 2021

AbstractDensity functional theory calculations were carried out to study the mechanisms of Pd‐catalyzed reactions of alkynes with tert‐butyl isocyanide forming pyrroles. In the case of di‐palladium catalysis, the calculations indicated that alkyne insertion, isocyanide insertion, intramolecular cyclization, isocyanide insertion, isomerization and ligand substitution were involved in the mechanism. The intramolecular cyclization process was calculated to be the rate‐determining step in the catalytic cycle. The substituent effects on the regioselectivity of reaction were also analyzed. In addition, detailed calculations on mono‐palladium catalysis showed that the activity of mononuclear catalysis was not as high as that of di‐palladium catalysis. These calculation results were in good agreement with the experimental results.
Oral health profile of postbariatric surgery individuals: A case series
Authors: Taghat Negin , Mossberg Karin , Lingström Peter , Björkman Sofia , Lehrkinder Anna , Werling Malin , Östberg Anna‐Lena 
Published: March 2021

AbstractObjectivesTo describe the oral health profile of individuals who had undergone gastric bypass surgery (GBP) or sleeve gastrectomy (SG) to generate hypotheses for further studies.Material and MethodsFourteen individuals treated with GBP or SG surgery ≥ 2 years ago and with observed and/or perceived oral problems were recruited to a case series. The documentation included clinical and radiographic examinations, biomedical sampling, and self‐reported diet and questionnaires. The results are presented descriptively.Results: The age range was 31 to 66 years and all had a BMI > 25 (range 25.4–44.7). Only four participants were fully dentate. Eleven out of 14 individuals exhibited severe decay. A majority had poor oral hygiene and high bacterial counts. The flow rates of unstimulated saliva were extremely low and hyposalivation was present in ten of the fourteen cases. Most perceived several oral health problems, such as chewing difficulty and tooth hypersensitivity.ConclusionsIndividuals who had undergone GBP or SG surgery had poor clinically diagnosed oral health and perceived oral health problems. Longitudinal studies are needed to monitor the patients' oral health, from before bariatric surgery to long‐term postoperatively.
Clinical value of 2D speckle tracking imaging in evaluating the effect of percutaneous intramyocardial septal radiofrequency ablation in patients with hypertrophic obstructive cardiomyopathy
Authors: Qian Dajun , Zhou Xiaojun , Liu Huan , Cao Lijun 
Published: March 2021

AbstractPurposeTo explore the short‐term changes after percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) in patients with hypertrophic obstructive cardiomyopathy (HOCM), using quantitative analysis of two‐dimensional speckle tracking imaging (2D‐STI).MethodsThis prospective self‐controlled study included 30 HOCM patients treated with PIMSRA. The study for each patient spanned over at least 1 year. Interventricular septal thickness and the left ventricular outflow tract peak pressure gradient (LVOT‐PG) were measured through echocardiography, and 2D‐STI was used to evaluate the left ventricular (LV) systolic function and synchrony. Cardiac function was assessed using the New York Heart Association's (NYHA) functional classification for cardiac disease, and through the serum levels of cardiac troponin I (cTnI) and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP). Biomarkers procollagen type I carboxy‐terminal propeptide (PICP) and matrix metalloproteinases‐2 (MMP‐2) were detected for noninvasive assessment of myocardial fibrosis.ResultsThe patients' interventricular septal thickness, LVOT‐PG, NYHA class, and plasma PICP and MMP‐2 levels at the first month postoperatively were significantly lower than before operation (all P < .05). The 2D‐STI quantitative variables of LV systolic function and synchrony improved significantly (all P < .05). They improved further 1 year postoperatively (P < .01 or P < .001). Serum cTnI and NT‐proBNP levels increased 1 month postoperatively, but significantly decreased 1 year postoperatively (both P < .05). Pearson or Spearman correlation analysis showed that the improvement of interventricular septal thickness, LVOT‐PG, NYHA class, and the levels of cTnI, NT‐proBNP, PICP and MMP‐2, were in positive correlation with the restoration of LV systolic function and synchrony (P < .01 or P < .001).ConclusionThe changes in 2D‐STI quantitative variables related to LV systolic function and synchrony are closely correlated with the improvement of cardiac function in HOCM patients after PIMSRA. These 2D‐STI variables can serve for objective, accurate, and noninvasive evaluation of the HOCM treatment.
Real‐world management of maple syrup urine disease (MSUD) metabolic decompensations with branched chain amino acid‐free formulas in France and Germany: A retrospective observational study
Authors: de Lonlay Pascale , Posset Roland , Mütze Ulrike , Mention Karine , Lamireau Delphine , Schiff Manuel , Servais Aude , Arnoux Jean Baptiste , Brassier Anaïs , Dao Myriam , Douillard Claire , Ottolenghi Chris , Pontoizeau Clément , Miotto Federica , Le Mouhaër Jeannie 
Published: March 2021

AbstractMaple syrup urine disease (MSUD) is a rare inborn metabolic disorder, managed with a strict protein‐restricted diet. At any time or age patients may still experience metabolic decompensations, requiring administration of branched chain amino acid (BCAA)‐free formula to reduce leucine levels. This retrospective observational study of 126 decompensation episodes from 54 MSUD patients treated at five centers in France and Germany from 2010 to 2016, describes episodes and outcomes for patients stratified into groups who received enteral/oral or intravenous (IV) BCAA‐free formula, and by pediatric or adult age categories. IV administration of BCAA‐free formula was required in cases of gastric intolerance (33%), refusal to undergo nasogastric tubing (31%), “emergency” (14%) or coma patients (8%), and as prophylaxis before surgery (6%). Overall, mean duration of hospitalization was 6.6 days with oral/enteral BCAA‐free formula and 5.4 days with IV formula. Leucine levels at discharge decreased by a mean of 548.5 μmol/L (69.3%) in the oral/enteral group and 657.2 μmol/L (71.3%) in the IV group. In the pediatric subgroup, there were no marked differences between administration groups on any outcome. In the adult subgroup, mean time to episode resolution was 15.8 days in the oral/enteral group and 7.7 days in the IV group (P = .008); mean duration of hospitalization was 6 days in the oral/enteral group and 4.6 days in the IV group (P = NS). Overall, seven serious adverse events in two patients were reported, of which only nausea and vomiting were treatment related.
Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma
Authors: Leeson Sarah , Jayamohan Jayasingham , Vu Hanh , Sundaresan Puma 
Published: March 2021

AbstractIntroductionMost primary ocular adnexal lymphomas are those involving mucosa‐associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML).MethodsPatients treated for stage I or II POAML over a 12‐year period (July 2006 to June 2018) were identified through institutional databases. Data were retrospectively collated through review of patient records. Descriptive statistical methods were employed to analyse the data.ResultsEighteen patients (median age of 67; range 44‐87yrs) with localised POAML (3 cases of bilateral disease) were identified, resulting in a total of 21 evaluable orbits. Eight (44%) patients were female, and all were documented to be of good performance status (ECOG 0‐1). The median follow‐up was 34 months (range 8‐75 months). The commonest dose fractionation used was 20 Gy in 10 fractions (n = 13 orbits) and a 3D conformal or volumetric modulated arc therapy (VMAT) technique was used in the majority of cases. None of the patients experienced an in‐field recurrence. One patient had experienced a contralateral orbital recurrence two years post‐unilateral orbital RT for orbital MALT lymphoma. Three patients experienced distant relapse.ConclusionThe use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. The durability of the response appears to be favourable. Given the indolent nature of the disease and the low levels of toxicity associated with lower dose orbital RT, this regimen remains our favoured approach to the management of localised POAML.
Fabrication of Regenerated Cellulose Fibers with Good Strength and Biocompatibility from Green Spinning Process of Ionic Liquid
Authors: Zhou Le , Kang Zhaoqing , Nie Yi , Li Liying 
Published: March 2021

AbstractIn this study, 1‐ethyl‐3‐methylimidazolium diethyl phosphate, having the advantages of regulating the performance of cellulose dissolution and degradation, simplicity in synthesis, is chosen as solvent to dissolve wood pulp cellulose for regenerated cellulose fibers (RCFs) manufacture using dry‐jet wet spinning equipment. The effect of draw ratios on RCFs’ mechanical properties in three bathes, including coagulation bath, stretch bath, and washing bath is investigated and a series of RCFs with high strength are obtained. The morphology, crystallinity, thermal stability, and dyeing behavior of the prepared RCFs are analyzed and discussed. More importantly, the biocompatibility of the RCFs, which is first performed, demonstrated that the toxicity of RCFs is as low as the viscose fibers. These RCFs could be easily dyed by natural turmeric and antibacterial fibers are obtained finally. In conclusion, this work provides tools for achievement of RCFs with good strength and environmental friendliness by changing the draw ratios, and also further develops a new green process for fabricating RCFs based on ionic liquids.