bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flowback Test Analyses at the Utah Frontier Observatory for Research in Geothermal Energy (FORGE) Site
Authors: Xing Pengju , Damjanac Branko , Moore Joseph , McLennan John 
Published: September 2021

AbstractIn 2017 and 2019, injection testing was carried out in three zones in a vertical well in granite at the Frontier Observatory for Research in Geothermal Energy site near Milford, Utah, USA. In several injection cycles, flowback was implemented rather than shut-in. The goal was to explore an alternative to prolonged shut-in periods for inferring closure stress, formation compressibility, and formation permeability (permeability thickness product). The flowback procedures involved a cyclic flowback/shut-in, while pressure decreased. The flowback data are presented, and analyses are shown. The inferred closure stress(es) from flowback analyses are lower than for equivalent injection cycles that were strictly shut-in. Relatively high formation compressibility obtained from the flowback analyses indicates an extensive, fractured system. This study also includes numerical simulation of the flowback events. The numerical model shows that the rebound pressure is not necessarily the lower bound of the minimum principal stress. The signature of stiffness change can be identified as the process when the depletion mainly transitions from hydraulic fracture to natural fractures from numerical analysis. Overall, flowback potentially has advantages over shut-in because of the reduced time to closure.
A systematic review and meta-analysis of technical aspects and clinical outcomes of botulinum toxin prior to abdominal wall reconstruction
Authors: Timmer A. S. , Claessen J. J. M. , Atema J. J. , Rutten M. V. H. , Hompes R. , Boermeester M. A. 
Published: September 2021

Abstract
Purpose
To systematically review technical aspects and treatment regimens of botulinum toxin A (BTA) injections in the lateral abdominal wall musculature. We also investigated the effect of BTA on abdominal muscle- and hernia dimensions, and clinical outcome.

Methods
PubMed, EMBASE, CENTRAL, and CINAHL were searched for studies that investigate the injection of BTA in the lateral abdominal wall muscles. Study characteristics, BTA treatment regimens, surgical procedures, and clinical outcomes are presented descriptively. The effect of BTA on muscle- and hernia dimensions is analyzed using random-effects meta-analyses, and exclusively for studies that investigate ventral incisional hernia patients.

Results
We identified 23 studies, comprising 995 patients. Generally, either 500 units of Dysport® or 200–300 units of Botox® are injected at 3–5 locations bilaterally in all three muscles of the lateral abdominal wall, about 4 weeks prior to surgery. No major procedural complications are reported. Meta-analyses show that BTA provides significant elongation of the lateral abdominal wall of 3.2 cm per side (95% CI 2.0–4.3, I2 = 0%, p < 0.001); 6.3 cm total elongation, and a significant but heterogeneous decrease in transverse hernia width (95% CI 0.2–6.8, I2 = 94%, p = 0.04). Furthermore, meta-analysis shows that BTA pretreatment in ventral hernia patients significantly increases the fascial closure rate [RR 1.08 (95% CI 1.02–1.16, I2 = 0%, p = 0.02)].

Conclusion
The injection technique and treatment regimens of botulinum toxin A as well as patient selection require standardization. Bilateral pretreatment in hernia patients significantly elongates the lateral abdominal wall muscles, making fascial closure during surgical hernia repair more likely.

Study registration
A review protocol for this meta-analysis was registered at PROSPERO (CRD42020198246).
Effects of block shape and inclination on the stability of melange bimrocks
Authors: Napoli Maria Lia , Barbero Monica , Scavia Claudio 
Published: September 2021

AbstractA wide range of heterogeneous geological units composed of strong rock blocks enclosed in a bonded matrix of fine texture exists worldwide. Such geomaterials belong to geotechnically complex formations and are often referred to as bimrocks (block-in-matrix rocks) or bimsoils (block-in-matrix soils), as a function of their matrix characteristics and the interface strength between the matrix and blocks. Stability problems occurring in such complex geomaterials have been analysed almost exclusively by means of deterministic approaches and with the aim of investigating the effects of variable block contents on their mechanical behaviour. However, bimrocks and bimsoils can present very different internal block-in-matrix arrangements and properties according to their forming process and, consequently, significantly dissimilar mechanical behaviours. Therefore, the aim of this paper was to statistically investigate and compare the stability of theoretical slopes in the most widespread bimrock formations, i.e. sedimentary and tectonic melanges. These formations are characterised by substantial differences in their rock inclusion geometry. To this aim, a great number of 2D slope models were generated to enclose blocks with variable shapes, dimensions, arrangements, inclinations and contents. To obtain statistically based results, fifteen configurations were analysed for each block content and geometrical configuration considered. The results obtained indicate that block shapes and orientations significantly affect the stability of slopes in bimrocks only when the block contents are greater than 40%. Moreover, it is demonstrated that blocks inclined 0° to the horizontal provide the most tortuous and irregular failure surfaces and, consequently, the highest safety factors.
A review on initiatives for the management of daily medical emergencies prior to the arrival of emergency medical services
Authors: Matinrad Niki , Reuter-Oppermann Melanie 
Published: September 2021

AbstractEmergency services worldwide face increasing cost pressure that potentially limits their existing resources. In many countries, emergency services also face the issues of staff shortage–creating extra challenges and constraints, especially during crisis times such as the COVID-19 pandemic–as well as long distances to sparsely populated areas resulting in longer response times. To overcome these issues and potentially reduce consequences of daily (medical) emergencies, several countries, such as Sweden, Germany, and the Netherlands, have started initiatives using new types of human resources as well as equipment, which have not been part of the existing emergency systems before. These resources are employed in response to medical emergency cases if they can arrive earlier than emergency medical services (EMS). A good number of studies have investigated the use of these new types of resources in EMS systems, from medical, technical, and logistical perspectives as their study domains. Several review papers in the literature exist that focus on one or several of these new types of resources. However, to the best of our knowledge, no review paper that comprehensively considers all new types of resources in emergency medical response systems exists. We try to fill this gap by presenting a broad literature review of the studies focused on the different new types of resources, which are used prior to the arrival of EMS. Our objective is to present an application-based and methodological overview of these papers, to provide insights to this important field and to bring it to the attention of researchers as well as emergency managers and administrators.
A longitudinal analysis of the reciprocal relationship between academic procrastination, study satisfaction, and dropout intentions in higher education
Authors: Scheunemann Anne , Schnettler Theresa , Bobe Julia , Fries Stefan , Grunschel Carola 
Published: September 2021

AbstractStudent dropout is a multi-causal process. Different theoretical models on student dropout consider dysfunctional study behavior (e.g., academic procrastination) and low study satisfaction as possible determinants of students’ dropout intentions during their university studies. However, these models neglect contemporary conceptualizations that assume reverse relationships between dropout intentions and other determinants of the dropout process. Until now, empirical evidence on these assumptions is scant. The present three-wave longitudinal study explored the reciprocal relationships between academic procrastination, study satisfaction, and dropout intentions over one semester. To this end, we used data of N = 326 undergraduate students enrolled in mathematics and law. Our latent cross-lagged panel model replicated existing empirical cross-sectional findings between the variables (i.e., academic procrastination, study satisfaction, and dropout intentions). Regarding the longitudinal relations, as expected, the cross-lagged effects showed that higher dropout intentions significantly related to subsequent higher academic procrastination and lower study satisfaction. Unexpectedly, academic procrastination did not significantly relate to subsequent dropout intentions. Additionally, higher study satisfaction significantly associated with subsequent higher dropout intentions—possibly due to unfulfilled expectations. Further, higher study satisfaction significantly related to subsequent higher procrastination—possibly due to more confidence among satisfied students. Our results broaden the view on dropout intentions as part of the dynamic interplay of student dropout determinants and the need to refine dropout models’ assumptions accordingly. Practically, realistic expectations seem important to reduce dropout intentions. Further, student counselors should have a closer look at the reasons for academic procrastination to develop individual solutions for this dysfunctional behavior.
Digitale Ordnungspolitik — Wirtschaftspolitik daten- und evidenzbasiert weiterentwickeln
Authors: Steinberg Philipp , Börnsen Nils , Neumann Dirk 
Published: September 2021

ZusammenfassungDie Digitalisierung bringt weitreichende Änderungen für Wirtschaft und Gesellschaft mit sich. Vor diesem Hintergrund hat das Bundesministerium für Wirtschaft und Energie als Teil der Umsetzungsstrategie „Digitalisierung gestalten“ der Bundesregierung im Dezember 2020 ein Konzeptpapier für ein ordnungspolitisches Handlungsprogramm zur Unterstützung des digitalen Wandels veröffentlicht. Dessen Kernthese ist, dass die Grundgedanken der Ordnungspolitik in der digitalen Wirtschaft gültig bleiben. Ihre Grundsätze sind bis heute Pfeiler der Sozialen Marktwirtschaft und können in einer zunehmend digitalen Wirtschaft klare Orientierung für die Wirtschaftspolitik der Zukunft bieten. Das Konzeptpapier wird vorgestellt und einer der dort skizzierten Ansätze für die Umsetzung einer digitalen Ordnungspolitik genauer beleuchtet: die daten- und evidenzbasierte Weiterentwicklung der Wirtschaftspolitik.
Digitalisierungsschub in Firmen während der Corona-Pandemie
Authors: Bellmann Lutz , Bourgeon Pauline , Gathmann Christina , Kagerl Christian , Marguerit David , Martin Ludivine , Pohlan Laura , Roth Duncan 
Published: September 2021

ZusammenfassungDurch die Corona-Pandemie haben digitale Technologien in Unternehmen an Bedeutung gewonnen. Auf Basis einer Betriebsbefragung des Instituts für Arbeitsmarkt- und Berufsforschung untersuchen die Autor:innen, ob Unternehmen vermehrt in digitale Technologien investiert haben und welche Rolle dabei die wirtschaftliche Situation gespielt hat. Neben den Investitionen in digitale Technologien haben auch Weiterbildungsaktivitäten in den Betrieben zugenommen.
Long non-coding RNA FOXP4-AS1 facilitates the biological functions of hepatocellular carcinoma cells via downregulating ZC3H12D by mediating H3K27me3 through recruitment of EZH2
Authors: Ye Junfeng , Fu Yu , Wang Zhongfeng , Yu Jinhai 
Published: September 2021

Abstract
Background
Some studies have reported the effect of long non-coding RNA forkhead box P4 antisense RNA 1 (lncRNA FOXP4-AS1) on hepatocellular carcinoma (HCC). Here, we aimed to discuss the effects of FOXP4-AS1/enhancer of zeste homolog 2 (EZH2)/trimethylation of lysine 27 on histone H3 (H3K27me3)/zinc finger CCCH-type containing 12D (ZC3H12D) axis on HCC.

Methods
The expression of FOXP4-AS1, EZH2, and ZC3H12D, and abundance of H3K27me3 in HCC tissues and cells were tested. The relationship between FOXP4-AS1 expression and prognosis of HCC patients was analyzed. The biological functions of HCC cells were detected via loss- and gain-of-function assays. The tumor weight and volume in vivo were tested. The interaction between FOXP4-AS1 and EZH2 as well as that between EZH2 and H3K27me3 was verified.

Results
FOXP4-AS1 and EZH2 expression and H3K27me3 abundance were enhanced while ZC3H12D expression was depressed in HCC tissues and cells. Knockdown of FOXP4-AS1 suppressed biological functions of HCC cells as well as the weight and volume of HCC transplanted tumor. Depleting ZC3H12D reversed the effect of downregulated FOXP4-AS1 on HCC cells. FOXP4-AS1 suppressed ZC3H12D expression via mediating H3K27me3 by recruitment of EZH2.

Conclusion
The key findings of the present study demonstrate that FOXP4-AS1 suppresses ZC3H12D expression via mediating H3K27me3 by recruitment of EZH2, thus promoting the progression of HCC.

Graphical abstract
“Absent Contrary Indication”: On a Pernicious Form of Epistemic Luck, and its Epistemic Agency Antidote
Authors: Anaya Alfonso 
Published: September 2021

AbstractIt is widely accepted that knowledge is incompatible with the presence of non-neutralized defeaters. A common way of addressing this issue is to introduce a condition to the effect that there are no non-neutralized defeaters for the belief that p (i.e. a “no-defeaters condition”). I argue that meeting this condition leaves open a possibility for defeaters to squander our knowledge. The no-defeaters condition can be fortuitously met, and as a result it can be met luckily. I shall argue that this kind of luck is inconsistent with knowledge. In order to prevent this pernicious form of luck I introduce a “defeaters-responsiveness” condition, according to which subjects ought to be disposed to adequately address defeaters if they were to arise (even if they in fact do not arise).
Rules at Play: Correcting Projectable Violations of Who Plays Next
Authors: Svensson Hanna , Tekin Burak S. 
Published: September 2021

AbstractThis study examines the situated use of rules and the social practices people deploy to correct projectable rule violations in pétanque playing activities. Drawing on Ethnomethodology and Conversation Analysis, and using naturally occurring video recordings, this article investigates socially organized occasions of rule use, and more particularly how rules for turn-taking at play are reflexively established in and through interaction. The alternation of players in pétanque is dependent on and consequential for the progressivity of the game and it is a practical problem for the players when a participant projects to break a rule of “who plays next”. The empirical analysis shows that formulating rules is a practice for indicating and correcting incipient violations of who plays next, which retrospectively invoke and establish the situated expectations that constitute the game as that particular game. Focusing on the anticipative corrections of projectable violations of turn-taking rules, this study revisits the concept of rules, as they are played into being, from a social and interactional perspective. We argue and demonstrate that rules are not prescriptions of game conduct, but resources that reflexively render the players’ conducts intelligible as playing the game they are engaging in.
Towards psychology-aware preference construction in recommender systems: Overview and research issues
Authors: Atas Müslüm , Felfernig Alexander , Polat-Erdeniz Seda , Popescu Andrei , Tran Thi Ngoc Trang , Uta Mathias 
Published: September 2021

AbstractUser preferences are a crucial input needed by recommender systems to determine relevant items. In single-shot recommendation scenarios such as content-based filtering and collaborative filtering, user preferences are represented, for example, askeywords,categories, anditem ratings. In conversational recommendation approaches such as constraint-based and critiquing-based recommendation, user preferences are often represented on the semantic level in terms ofitem attribute valuesandcritiques. In this article, we provide an overview of preference representations used in different types of recommender systems. In this context, we take into account the fact thatpreferences aren’t stablebut are ratherconstructedwithin the scope of a recommendation process. In which way preferences are determined and adapted is influenced by various factors such aspersonality traits,emotional states, andcognitive biases. We summarize preference construction related research and also discuss aspects of counteracting cognitive biases.
Seeing is believing: the impact of body-worn cameras on court outcomes, a cluster-randomized controlled trial in Miami Beach
Authors: Petersen Kevin , Mouro Alejandro , Papy Donald , Castillo Noel , Ariel Barak 
Published: September 2021

Abstract
Objectives
To assess the effects of BWCs on prosecutorial and court-related charge outcomes across multiple crime types, including domestic violence charges, crimes committed against police officers, and drug/alcohol charges.

Methods
A cluster-randomized controlled trial with 22 spatiotemporal police units assigned to BWCs and 17 assigned to control conditions. Data from the State Attorney’s Office were used to track convictions, adjudication withheld dispositions, and declined prosecutions for both experimental and control charges. A series of multilevel logistic and negative binomial regression models were used to estimate the effect of BWC footage on charge outcomes.

Outcomes
BWCs led to a significantly higher proportion of crimes against police officers resulting in convictions or adjudication withheld outcomes, and a significantly higher proportion of domestic violence charges resulting in convictions alone, compared to control charges. However, after the clustering effect was taken into account, only the effect of BWCs on crimes against police officers remained statistically significant.

Conclusion
These early results suggest that BWCs have significant evidentiary value that varies by crime type. BWCs may be best suited to capture evidence of crimes committed against police officers and potentially in domestic violence offenses as well.
The impact of Rumex vesicarius seed water extracts on mice fertility
Authors: Alhimaidi Ahmad Rashed , Ammari Aiman Abdullah. , Okla Mohammad Khair , Algadi Muath Qasem , Amran Ramzi Ahmed , Alhusayni Hissah Ibrahim , Alhimaidi Mohammed Ahmad 
Published: September 2021

AbstractRumex vesicarius(RV) is an edible wild annual plant, and it is reported that it contains a good source of minerals, protein, and ascorbic acid. Several studies have indicated the anti-liver damage, anticancer, antimicrobial, and antioxidant properties of the RV plant. There are currently no reports regarding the effect of RV on fertility. Therefore, this study focuses on the impact of RV water seed extracts on mice fertility. RV plants were collected, and water seed extracts were prepared; 50 mg/kg body weight (BW) of this was then injected into the mice (male and female) using an oral feeding tube 5 days before mating (group I) or during caging of the females with the males for 1 week to detect their fertility rate. In the different female groups, no significant difference between their BW and their newborn’s BW in the treated and control groups was found. Female fertility, pregnancy, and offspring rates showed some variation within each female group and between the different female groups. In comparing the fertility and offspring rate between the different groups, there was a significant difference (P< 0.05) between groups I and III females and between groups I and IV females, while the other groups showed no significant differences. In contrast, the other groups showed no significant differences. Regarding the impact of the water seed extract on males, the BW was approximately the same in control and treated males.
LCA and nutritional assessment of southern Benin market vegetable gardening across the production continuum
Authors: Avadí Angel , Hodomihou Nounagnon Richard , Amadji Guillaume Lucien , Feder Frédéric 
Published: September 2021

AbstractPurposeThe goal of this work is to analyse the environmental impacts across the productive continuum of market gardening in southern Benin, to determine whether significant differences exist amongst the types of production, and to highlight their hotpots suitable to improvement. Moreover, the relative nutritional quality of products from different production system types were compared to determine whether there were differences and to assess them in relation to the associated environmental impacts.MethodsLCA and laboratory analyses were performed on a representative sample of systems and products (carrot, cucumber, tomato, lettuce, watermelon). The resulting scores (single scores for LCA and Nutrient Rich Food scores for nutritional quality) were statistically treated to identify the representativeness of their differences across production sites and production types (featuring distinctive production strategies: Conventional — synthetic fertilisers and pesticides, Organic — organic fertilisers and pesticides and “Lean” — limited inputs).Results and discussionStatistically significant differences across environmental scores were found amongst production sites (for carrot, lettuce and all crops) and types (for carrot and all crops). For tomato, produced on all sites, under all production types, the natural and management-driven variability is large enough that no significant differences were found. Impacts are dominated by direct emissions from (over-)fertilisation and by fuel consumption for water pumping. Despite the absence of significant differences amongst production system types regarding the contents of both β-carotene and polyphenols, the nutritional indices suggest at least marginal differences across types regarding the overall nutritional value of carrot and tomato across types. Based on the limited data available, it cannot be stated that such differences are statistically significant. For carrot, there seems to be a correlation between nutritional quality and environmental impacts, with higher nutritional scores associated with lower environmental impacts. For tomato, it does not seem to exist a correlation.ConclusionsSignificant differences in environmental scores exist amongst the types of production, with the larger impact associated with organic production, whilst that no statistically significant differences on nutritional quality can be demonstrated across types. Overall improvement of these systems would be achieved by less energy-intensive irrigation, organic waste processing platforms to reduce volatilisation losses, knowledge on the fertilising value of organic waste, and agricultural extension services or technical guides on good agricultural practices to reduce over-fertilisation and other negative environmental impacts.