bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epitypification of the Linnaean name Crepis bursifolia (Asteraceae)
Authors: Iamonico Duilio , Fortini Paola , Di Pietro Romeo 
Published: October 2021

AbstractThe epitypification of the Linnaean name Crepis bursifolia is discussed. An illustration from Boccone's Museo di piante rare della Sicilia, Malta, Corsica, Italia, Piemonte, e Germania was correctly designated as lectotype by Jiménez López & al. in 2013 according to Art. 7.11 of the ICN. However, this image lacks some of the important characters required for a critical identification of the species (i.e., hairiness of receptacle, length of achenes, number of ribs on the achene surface, and presence of a distinct apical beak on the achene). Following Art. 9.9 of the ICN, an epitype deposited at HFLA is selected to serve as an interpretative type of the lectotype of C. bursifolia.
Nano‐selenium attenuates mitochondrial‐associated apoptosis via the PI3K/AKT pathway in nickel‐induced hepatotoxicity in vivo and in vitro
Authors: Wang Caixia , Gu Zhangyu , Gu Xueyan , Tan Xinyue , Wang Shuang , Zhang Rui , Li Ruifen , Sun Mingkun , Gui Chunyan , Li Sheng , Ye Yixing , Ma Jianhua , Su Li , Liang Changhao 
Published: October 2021

AbstractThe aim of this study was to investigate the protective effects of Nano‐Se against nickel (Ni)‐induced hepatotoxicity and the potential mechanism. Hence, we constructed in vivo and in vitro models of Ni‐induced hepatotoxicity. Sprague–Dawley (SD) rats were exposed to nickel sulfate (NiSO4, 5.0 mg/kg, i.p.) with or without Nano‐Se (0.5, 1, and 2 mg/kg, oral gavage) co‐administration for 14 days, and HepG2 cells were exposed to NiSO4 (1500 μM) with or without Nano‐Se (20 μM) for 24 h. Nano‐Se obviously prevented Ni‐induced hepatotoxicity indicated by ameliorating pathological change and decreasing Ni accumulation in rat livers. Ni induced a significant increase in hepatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH‐Px), and malondialdehyde (MDA) level, decreased the glutathione (GSH) content while compared to those in the control group. Nano‐Se administration improved the hepatic antioxidant capacity through increase hepatic GSH contents and GSH‐Px activity, decrease the activities of SOD, CAT, and MDA level. Nano‐Se improved the cell viability, decreased active oxygen (ROS) generation and ameliorated morphological changes of nuclear structures in Ni‐treated HepG2 cells. In addition, Nano‐Se inhibited the Ni‐induced increases of cytochrome c, caspase‐9, cleaved caspase‐3, increased PI3K and AKT phosphorylation both in vivo and in vitro. Besides, the PI3K inhibitor Y294002 could inhibit the protective effects of Nano‐Se on apoptosis. Thus, Nano‐Se significantly activates PI3K/AKT signaling to ameliorate apoptosis in Ni‐induced hepatotoxicity.
Diestrous diabetes mellitus remission in a Yorkshire terrier bitch
Authors: Staroňová Radka , Kožár Martin , Horňáková Ľubica , Fialkovičová Mária 
Published: October 2021

AbstractRemission of diabetes mellitus in dogs is a very rare condition. In our case, the clinical signs of diabetes mellitus in the nine‐ year‐old Yorkshire terrier bitch disappeared three months after a therapeutic ovariohysterectomy. The diagnosis of diestrous diabetes mellitus, requiring insulin supplementation, was confirmed on the basis of anamnesis, symptomatology, clinical examination and specific laboratory tests. The chosen therapy and a change in diet led to the stabilization of the patient and its preparation for surgery. Repeated follow‐ups, consisting of control blood samplings for glucose and progesterone levels and urinanalysis, has ensured control of insulin therapy and proper insulin dosing. Three weeks after ovariohysterectomy, normoglycaemia, confirmed by control trials, resulted in gradual discontinuation of insulin administration. The stable health status of the patient two months after the performance of therapeutic ovariohysterectomy confirmed the remission of the disease without the need for further insulin supplementation and regular monitoring.
Abatement of water nutrient load in a fish culture system using the aquatic trophic levels
Authors: Poorbagher Hadi , Rafiee Gholamreza , Rezaei Tavabe Kamran , Moezzi Fateh 
Published: October 2021

AbstractIntegrated aquatic systems are used to decrease the nutrient loads of effluents negating the negative environmental impacts of aquacultural systems. Some of these systems have a separate algae compartment requiring high maintenance. An integrated culture system was set up with different trophic levels: algae, zooplankton, and fish. The algal tank was in‐line with the fish and zooplankton components to minimize the maintenance required for the algae. A control flow‐through system was also set up without the algae and zooplankton compartments. The systems were run for 6 weeks, and water temperature, pH, dissolved oxygen, NO3, NO2, NH4, and PO4 concentrations were measured. A removal rate was determined for each water parameter and the densities of the algae and zooplankton species were measured in each compartment of the integrated system. The concentrations of most nutrients in the integrated system were similar to those of the control system. The density of algae increased during the first 3 weeks and remained almost stable until the end of the experiment. There was an inverse relationship between the densities of two zooplankton suggesting compensatory effects on the control of the algal bloom. The integrated system improved water quality with minimal algal culture maintenance, water exchange, and no fish mortality.Practitioner Points

An integrated system could effectively reduce the nutrient load of water.
Water replacement in the integrated system was significantly lower than that of a flow through system.
The inline plankton culture tanks decreased greatly the maintenance of the system.
Submerging islands through thermalization
Authors: Balasubramanian Vijay , Craps Ben , Khramtsov Mikhail , Shaghoulian Edgar 
Published: October 2021

Abstract
We illustrate scenarios in which Hawking radiation collected in finite regions of a reservoir provides temporary access to the interior of black holes through transient entanglement “islands.” Whether these islands appear and the amount of time for which they dominate — sometimes giving way to a thermalization transition — is controlled by the amount of radiation we probe. In the first scenario, two reservoirs are coupled to an eternal black hole. The second scenario involves two holographic quantum gravitating systems at different temperatures interacting through a Rindler-like reservoir, which acts as a heat engine maintaining thermal equilibrium. The latter situation, which has an intricate phase structure, describes two eternal black holes radiating into each other through a shared reservoir.
K-subadditive and K-superadditive set-valued functions bounded on “large” sets
Authors: Jabłońska Eliza , Nikodem Kazimierz 
Published: October 2021

AbstractWe prove that every K–subadditive set–valued map weakly K–upper bounded on a “large” set (e.g. not null–finite, not Haar–null or not a Haar–meager set), as well as any K–superadditive set–valued map K–lower bounded on a “large” set, is locally K–lower bounded and locally weakly K–upper bounded at every point of its domain.
Parameter identification of a second-gradient model for the description of pantographic structures in dynamic regime
Authors: Shekarchizadeh Navid , Laudato Marco , Manzari Luca , Abali Bilen Emek , Giorgio Ivan , Bersani Alberto Maria 
Published: October 2021

AbstractPantographic structures are examples of metamaterials with such a microstructure that higher-gradient terms’ role is increased in the mechanical response. In this work, we aim for validating parameters of a reduced-order model for a pantographic structure. Experimental tests are carried out by applying forced oscillation to 3D-printed specimens for a range of frequencies. A second-gradient coarse-grained nonlinear model is utilized for obtaining a homogenized 2D description of the pantographic structure. By inverse analysis and through an automatized optimization algorithm, the parameters of the model are identified for the corresponding pantographic structure. By comparing the displacement plots, the performance of the model and the identified parameters are assessed for dynamic regime. Qualitative and quantitative analyses for different frequency ranges are performed. A good agreement is present far away from the eigenfrequencies. The discrepancies near the eigenfrequencies are a possible indication of the significance of higher-order inertia in the model.
Implementierung eines individualisierbaren tabletbasierten Trainingsprogramms im Anschluss an eine Parkinson-Komplexbehandlung in der Häuslichkeit – Erfolgsfaktoren und Barrieren
Authors: Wagner Lynn , Deck Ruth 
Published: October 2021

ZusammenfassungHintergrundRegelmäßige körperliche Aktivität ist bei Morbus Parkinson von großer Relevanz. Im Rahmen des Projekts „Individualisiertes Trainingsprogramm für Parkinson-Patienten“ (ParkProTrain) wurde ein individualisierbares tabletbasiertes Programm zur Unterstützung eines individuellen Eigentrainings entwickelt und über einen Zeitraum von 9 Monaten in der Häuslichkeit erprobt. Patienten wurden zur Machbarkeit der Nutzung und zur Zufriedenheit befragt.MethodikPatienten, die das Programm im Anschluss an eine stationäre multimodale Komplexbehandlung bei Morbus Parkinson (Parkinson-Komplexbehandlung, PKB) in der Häuslichkeit nutzten, wurden zu zwei Zeitpunkten (9 und 36 Wochen nach PKB) im Rahmen qualitativer Interviews befragt.ErgebnisseDas Programm half den Patienten über die gesamte Interventionszeit hinweg, motiviert zu bleiben. Es bot ihnen sowohl Struktur als auch Flexibilität für die Entwicklung einer eigenen Trainingsroutine. Als positive Aspekte (Erfolgsfaktoren) wurden u. a. benannt: die Einführungsseminare in der Klinik, die enge Betreuung während der Interventionszeit, die Fundiertheit und der Parkinson-Bezug, die Machbarkeit und die Handhabbarkeit des Programms sowie die individualisierten Trainingspläne. Patienten geben aber auch Hinweise, wie das Programm noch optimiert werden könnte (Barrieren).DiskussionDas Programm unterstützt die Patienten bereits erfolgreich mit einer Vielzahl aktivitätsfördernder Ideen. Es konnten weitere Empfehlungen für zukünftige Vorhaben abgeleitet werden, die verstärkt beachtet werden sollten: Parkinson-Spezifität und Individualisierbarkeit des Programms, örtlich und zeitlich flexibles Training, enge und persönliche Betreuung über die gesamte Studienlaufzeit hinweg und eine einfach erlernbare und handhabbare Technik.
Hart–Mas-Colell consistency and the core in convex games
Authors: Dietzenbacher Bas , Sudhölter Peter 
Published: October 2021

AbstractThis paper formally introduces Hart–Mas-Colell consistency for general (possibly multi-valued) solutions for cooperative games with transferable utility. This notion is used to axiomatically characterize the core on the domain of convex games. Moreover, we characterize all nonempty solutions satisfying individual rationality, anonymity, scale covariance, superadditivity, weak Hart–Mas-Colell consistency, and converse Hart–Mas-Colell consistency. This family consists of (a) the Shapley value, (b) all homothetic images of the core with the Shapley value as center of homothety and with positive ratios of homothety not larger than one, and (c) their relative interiors.
A possible role of gas-phase electrophoretic mobility molecular analysis (nES GEMMA) in extracellular vesicle research
Authors: Steinberger Stephanie , Karuthedom George Sobha , Lauková Lucia , Weiss René , Tripisciano Carla , Birner-Gruenberger Ruth , Weber Viktoria , Allmaier Günter , Weiss Victor U. 
Published: October 2021

AbstractThe emerging role of extracellular vesicles (EVs) as biomarkers and their envisioned therapeutic use require advanced techniques for their detailed characterization. In this context, we investigated gas-phase electrophoresis on a nano electrospray gas-phase electrophoretic mobility molecular analyzer (nES GEMMA, aka nES differential mobility analyzer, nES DMA) as an alternative to standard analytical techniques. In gas-phase electrophoresis, single-charged, surface-dry, native, polydisperse, and aerosolized analytes, e.g., proteins or bio-nanoparticles, are separated according to their electrophoretic mobility diameter, i.e., globular size. Subsequently, monodisperse particles are counted after a nucleation step in a supersaturated atmosphere as they pass a focused laser beam. Hence, particle number concentrations are obtained in accordance with recommendations of the European Commission for nanoparticle characterization (2011/696/EU from October 18th, 2011). Smaller sample constituents (e.g., co-purified proteins) can be detected next to larger ones (e.g., vesicles). Focusing on platelet-derived EVs, we compared different vesicle isolation techniques. In all cases, nanoparticle tracking analysis (NTA) confirmed the presence of vesicles. However, nES GEMMA often revealed a significant co-purification of proteins from the sample matrix, precluding gas-phase electrophoresis of less-diluted samples containing higher vesicle concentrations. Therefore, mainly peaks in the protein size range were detected. Mass spectrometry revealed that these main contaminants belonged to the group of globulins and coagulation-related components. An additional size exclusion chromatography (SEC) step enabled the depletion of co-purified, proteinaceous matrix components, while a label-free quantitative proteomics approach revealed no significant differences in the detected EV core proteome. Hence, the future in-depth analysis of EVs via gas-phase electrophoresis appears feasible.
Graphical abstract
Shipbuilding capacity optimization using shipbuilding demand forecasting model
Authors: Wada Yujiro , Hamada Kunihiro , Hirata Noritaka 
Published: October 2021

AbstractThe shipbuilding industry has been drastically affected by demand fluctuations. Currently, it faces intense global competition and a crisis because of an imbalance between supply and demand. This imbalance of supply and demand is caused by an excess of shipbuilding capacity. The Organisation for Economic Co-operation and Development has considered adjusting the shipbuilding capacity to reduce the imbalance based on the demand forecast. On the other hand, demand forecast of shipbuilding is a complex issue because the demand is influenced indirectly by adjustments in shipbuilding capacity. Therefore, it is important to examine the influence of construction capacity adjustments on the future demand of ships based on demand forecasting for the sustainable growth of the shipbuilding industry. In this study, shipbuilding capacity adjustment is considered using a proposed simulation system based on a demand-forecasting model. Additionally, the system dynamics model of a previous study is improved by developing a ship price-prediction model for evaluating the shipbuilding capacity-adjustment scenario. We conduct simulations using the proposed demand-forecasting model and system to confirm the effectiveness of the proposed model and system. Furthermore, several shipbuilding capacity-adjustment scenarios are discussed using the proposed system.
Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes
Authors: Ye Changchang , You Meng , Huang Ping , Xia Zhongyi , Radaic Allan , Tang Jing , Wu Wanhong , Wu Yafei , Kapila Yvonne 
Published: October 2021

Abstract
Objectives
The objective of this study was to examine the association between the oral microbiome and pregnancy outcomes, specifically healthy or preterm low birth weight (PLBW) in individuals with and without periodontal disease (PD).

Material and methods
In this prospective clinical trial, we recruited 186 pregnant women, 17 of whom exhibited PD and delivered PLBW infants (PD-PLBW group). Of the remaining women, 155 presented PD and delivered healthy infants; 18 of these subjects with similar periodontal condition and age matched to the PD-PLBW group, and they became the PD-HD group. From the total group, 11 women exhibited healthy gingiva and had a healthy delivery (HD) and healthy infants (H-HD group), and 3 exhibited healthy gingiva and delivered PLBW infants (H-PLBW group). Periodontal parameters were recorded, and subgingival plaque and serum were collected during 26–28 gestational weeks. For the plaque samples, microbial abundance and diversity were accessed by 16S rRNA sequencing.

Results
Women with PD showed an enrichment in the genus Porphyromonas, Treponema, and Filifactor, whereas women with healthy gingiva showed an enrichment in Streptococcus, Actinomyces, and Corynebacterium, independently of the birth status. Although no significant difference was found in the beta diversity between the 4 groups, women that had PLBW infants presented a significantly lower abundance of the genus Neisseria, independently of PD status.

Conclusion
Lower levels of Neisseria align with preterm low birth weight in pregnant women, whereas a higher abundance of Treponema, Porphyromonas, Fretibacterium, and Filifactor and a lower abundance of Streptococcus may contribute to periodontal disease during pregnancy.

Clinical relevance
The oral commensal Neisseria have potential in the prediction of PLBW.
Markets Within the Limit of Feasibility
Authors: Silver Kenneth 
Published: October 2021

AbstractThe ‘limits of markets’ debate broadly concerns the question of when it is (im)permissible to have a market in some good. Markets can be of tremendous benefit to society, but many have felt that certain goods should not be for sale (e.g., sex, kidneys, bombs). Their sale is argued to be corrupting, exploitative, or to express a form of disrespect. InMarkets without Limits, Jason Brennan and Peter Jaworski have recently argued to the contrary: For any good, as long as it is permissible to give it for free, then it is permissible to give it for money. Their thesis has led to a number of engaging objections, and I leverage recent work on the nature of feasibility within political philosophy to offer a new challenge.I argue that feasibility offers a constraint on which markets can be permissibly implemented. Though it may be possible to create a morally acceptable version of an otherwise repugnant market, some of these markets may be infeasible, and so we are not permitted to implement them. After laying out this challenge, I consider several replies. They concern the relevance of feasibility, and whether any markets really are infeasible. This provides an opportunity to explore the dangers of pursuing the infeasible and with markets generally. I conclude by considering what might lead us to pursue these markets despite their infeasibility, or how knowledge of infeasibility may prove useful regardless.
Comparison Between Surface and Near-Surface Residual Stress Measurement Techniques Using a Standard Four-Point-Bend Specimen
Authors: Rahimi S. , Violatos I. 
Published: October 2021

AbstractBackgroundDetermination of near-surface residual stresses is challenging for the available measurement techniques due to their limitations. These are often either beyond reach or associated with significant uncertainties.ObjectiveThis study describes a critical comparison between three methods of surface and near-surface residual stress measurements, including x-ray diffraction (XRD) and two incremental central hole-drilling techniques one based on strain-gauge rosette and the other based on electronic speckle pattern interferometry (ESPI).MethodsThese measurements were performed on standard four-point-bend beams of steel loaded to known nominal stresses, according to the ASTM standard. These were to evaluate the sensitivity of different techniques to the variation in the nominal stress, and their associated uncertainties.ResultsThe XRD data showed very good correlations with the surface nominal stress, and with superb repeatability and small uncertainties. The results of the ESPI based hole-drilling technique were also in a good agreement with the XRD data and the expected nominal stress. However, those obtained by the strain gauge rosette based hole-drilling technique were not matching well with the data obtained by the other techniques nor with the nominal stress. This was found to be due to the generation of extensive compressive residual stress during surface preparation for strain gauge installation.ConclusionThe ESPI method is proven to be the most suitable hole-drilling technique for measuring near-surface residual stresses within distances close to the surface that are beyond the penetration depth of x-ray and below the resolution of the strain gauge rosette based hole-drilling method.
Pubertal development in 46,XY patients with NR5A1 mutations
Authors: Mönig Isabel , Schneidewind Julia , Johannsen Trine H. , Juul Anders , Werner Ralf , Lünstedt Ralf , Birnbaum Wiebke , Marshall Louise , Wünsch Lutz , Hiort Olaf 
Published: October 2021

Abstract
Purpose
Mutations in the NR5A1 gene, encoding the transcription factor Steroidogenic Factor-1, are associated with a highly variable genital phenotype in patients with 46,XY differences of sex development (DSD). Our objective was to analyse the pubertal development in 46,XY patients with NR5A1 mutations by the evaluation of longitudinal clinical and hormonal data at pubertal age.

Methods
We retrospectively studied a cohort of 10 46,XY patients with a verified NR5A1 mutation and describe clinical features including the external and internal genitalia, testicular volumes, Tanner stages and serum concentrations of LH, FSH, testosterone, AMH, and inhibin B during pubertal transition.

Results
Patients who first presented in early infancy due to ambiguous genitalia showed spontaneous virilization at pubertal age accompanied by a significant testosterone production despite the decreased gonadal volume. Patients with apparently female external genitalia at birth presented later in life at pubertal age either with signs of virilization and/or absence of female puberty. Testosterone levels were highly variable in this group. In all patients, gonadotropins were constantly in the upper reference range or elevated. Neither the extent of virilization at birth nor the presence of Müllerian structures reliably correlated with the degree of virilization during puberty.

Conclusion
Patients with NR5A1 mutations regardless of phenotype at birth may demonstrate considerable virilization at puberty. Therefore, it is important to consider sex assignment carefully and avoid irreversible procedures during infancy.