bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between Caveolin-1 (rs3807992) polymorphism and major dietary patterns on cardio-metabolic risk factors among obese and overweight women
Authors: Abaj Faezeh , Koohdani Fariba , Rafiee Masoumeh , Alvandi Ehsan , Yekaninejad Mir Saeed , Mirzaei Khadijeh 
Published: July 2021

Abstract
Background
Caveolin-1 (CAV-1) is a cholesterol-dependent essential component located in caveolae. Several studies have been CAV-1 related to cardio-metabolic parameters in animal models, however, there are few studies in humans. Importantly, there is no study has investigated the interaction between CAV-1 rs3807992 gene and dietary patterns (DPs) on cardio-metabolic risk factors.

Methods
The current cross-sectional study was conducted on 404 overweight and obese women. Dietary intake was obtained from FFQ with 147 items. The CAV-1 genotype was measured by the PCR-RFLP method. The anthropometric measurements, serum lipid profile, and inflammatory markers were measured by standard protocols.

Results
There was a significant interaction between CAV-1 rs3807992 and healthy DP on high-density cholesterol (HDL) (P-interaction = 0.03), TC/HDL (P-interaction = 0.03) and high sensitivity C-reactive protein (hs-CRP) (P-interaction = 0.04); in A-allele carriers, higher following a healthy DP was related to a higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy DP in relation to triglyceride (TG) (P-interaction = 0.001), aspartate aminotransferase (AST) (P-interaction = 0.01) and monocyte chemoattractant protein-1(MCP-1) (P-interaction = 0.01); A-allele carriers were more following the unhealthy DP had lower levels of TG, AST and MCP-1.

Conclusions
Our study revealed a significant gene-diet interaction between rs3807992 SNPs and DPs in relation to cardio-metabolic risk factors; A-allele carriers might be more sensitive to dietary composition compared to GG homozygotes. Following a healthy DP in A-allele-carriers may be improved their genetic association with cardio-metabolic risk factors.
Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice
Authors: Ali Amjad , Nasir Abdul , Shah Syed Wadood Ali , Khalil Atif Ali Khan , Ahn Mi-jeong , Shah Syed Muhammad Mukarram , Subhan Fazli , Faheem Muhammad , Sajjad Wasim , Shoaib Mohammad , Ahmad Saeed , Nazir Nausheen , Nisar Mohammad 
Published: July 2021

Abstract
Background
In order to find a new natural resource for pain-relief, the analgesic effects of Ilex dipyrena crude extract, fractions, and subfractions were evaluated in in-vivo mouse models with possible mechanism of action.

Methods
Analgesic effects of crude extract (100 and 200 mg/kg body weight), fractions and subfractions (75 mg/kg body weight) were screened using heat-induced (tail-immersion and hot plate test) and chemical-induced (formalin and acetic acid) nociception models in mice. The samples were also tested for the elucidation of a possible mechanism through opioidergic and GABAergic systems.

Results
The administration of crude extract, fractions and subfractions produced analgesic responses in acetic acid, formalin, tail immersion, and hot plate model for pain similar to those obtained with the standard. Naloxone antagonized the antinociceptive effects of the tested samples, whereas bicuculline showed partial inhibition. Considering the analgesic response, crude extract, fractions, and subfractions demonstrated promising inhibitory activity against all test models for pain, which was further supported by the possible involvement of opioidergic and GABAergic systems.

Conclusion
The results suggest that this plant may be useful in the development of new analgesic drugs. Further research with regard to the isolation of bioactive compounds is required to verify these findings.
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers
Authors: Alipanah Hiva , Farjam Mojtaba , Zarenezhad Elham , Roozitalab Ghazaal , Osanloo Mahmoud 
Published: July 2021

AbstractBackgroundMelanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more attention.MethodsThe anticancer effects of three essential oils from theCitrusfamily and their identified major constituents (limonene) were first investigated against melanoma and breast cancer cell lines (A-375 and MDA-MB-468). By preparing chitosan nanoparticles containing them, an attempt was then made to improve their effectiveness.ResultsChitosan nanoparticles containingCitrus sinensisandCitrus limonessential oils with IC50s of 0.03 and 0.124 μg/mL on A-375 cells, and 23.65 and 40.32 μg/mL on MDA-MB-468 showed distinct anticancer efficacies.ConclusionThe prepared formulations could thus be considered as green anticancer agents in complementary medicine and therapies.
Exploring community tuberculosis program in the pastoralist setting of Ethiopia: a qualitative study of community health workers’ perspectives in Borena Zone, Oromia Region
Authors: Megerso Abebe , Deyessa Negusie , Jarso Godana , Tezera Robel , Worku Alemayehu 
Published: July 2021

Abstract
Background
Pastoralist community accounts for a significant portion of the population in Ethiopia. This community is different from majority of the country’s population. Access to TB prevention and control services is uneven in the country. The community TB program is designed to improve the access. Exploring the program performance from the perspectives of its implemters in a pastoral setting remains important.

Method
We conducted a qualitative study using an interpretive description method in the pastoralist community setting of Ethiopia. Study participants were recruited from geographically dispersed areas. We collected data through in-depth interview using semi-structured interview guides and audio recordings during February 01–30, 2020. The guides were developed in consultation with TB program experts and clinicians treating TB patients in the study area. Notes were taken at the interviews to enrich transcription of the data. Principal investigator conducted the interview. The subsequent interviews were informed by emerging ideas from forgoing interview transcriptions and continued until data saturation was achieved.

Results
One hundred and fifty six codes, nine categories and three themes emanated. The first theme was inadequate community TB performance and some of its codes include inadequate presumptive TB case identification and compromised directly observed treatment short course service delivery. The second theme was factors contributing to the program performance. Community factors, lack of physical access to health facilities and indirect non-medical cost were some categories under this theme. The final theme was suggested solutions; and its categories include a need for active community involvement and modification of service delivery approaches.

Conclusions
Community TB performance was inadequate in the pastoralist community. Multifaceted factors contributed to the inadequate program performance. Socioeconomic and access related factors were major contributers. Aligning the program to the context of the pastoralist community setting is required to improve the performance.
Functional respiratory imaging assessment of budesonide/glycopyrrolate/formoterol fumarate and glycopyrrolate/formoterol fumarate metered dose inhalers in patients with COPD: the value of inhaled corticosteroids
Authors: van den Berge Maarten , De Backer Jan , Van Holsbeke Cedric , De Backer Wilfried , Trivedi Roopa , Jenkins Martin , Dorinsky Paul , Aurivillius Magnus 
Published: July 2021

Abstract
Background
For patients with chronic obstructive pulmonary disease (COPD), greater improvements in lung function have been demonstrated for triple versus dual inhaled therapies in traditional spirometry studies. This study was the first to use functional respiratory imaging (FRI), known for increased sensitivity to airway changes versus spirometry, to assess the effect of the inhaled corticosteroid (ICS) component (budesonide) on lung function in patients with moderate-to-severe COPD and a blood eosinophil count > 150 cells/mm3.

Methods
Patients in this Phase IIIb (NCT03836677), randomized, double-blind, crossover study received twice-daily budesonide/glycopyrrolate/formoterol fumarate (BGF) 320/18/9.6 μg fixed-dose triple therapy and glycopyrrolate/formoterol fumarate (GFF) 18/9.6 μg fixed-dose dual therapy over 4 weeks, each delivered via a single metered dose Aerosphere inhaler. Primary endpoints were the improvements from baseline for each treatment in specific (i.e. corrected for lobar volume) image-based airway volume (siVaw) and resistance (siRaw) measured via FRI taken at total lung capacity (Day 29). Secondary outcomes included spirometry and body plethysmography. Adverse events were monitored throughout the study.

Results
A total of 23 patients were randomized and included in the intent-to-treat analysis (mean age 64.9 years, 78.3% males, 43.5% current smokers, mean predicted post-bronchodilator forced expiratory volume in 1 s [FEV1] 63.6%). BGF and GFF both statistically significantly increased siVaw from baseline at Day 29 (geometric mean ratio [GM], 95% confidence interval [CI]: 1.72 [1.38, 2.13] and 1.53 [1.28, 1.83], respectively, both p < 0.0001), with a greater increase observed for BGF versus GFF (GM, 95% CI 1.09 [1.03, 1.16], p = 0.0061). Statistically significant reductions in siRaw were also observed with both BGF and GFF (GM, 95% CI 0.50 [0.39, 0.63] and 0.52 [0.40, 0.67], respectively, both p < 0.0001). Additionally, significant improvements from baseline in post-dose FEV1 were observed with BGF and GFF (mean 346 mL, p = 0.0003 and 273 mL, p = 0.0004, respectively). Safety findings were consistent with the known profiles of BGF and GFF.

Conclusions
As observed using FRI, triple therapy with BGF resulted in greater increases in airway volume, and reductions in airway resistance versus long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA) dual therapy with GFF, reflecting the ICS component’s contribution in patients with moderate-to-severe COPD.
Trial registration: ClinicalTrials.gov, NCT03836677. Registered 11 February 2019, https://clinicaltrials.gov/ct2/show/NCT03836677
Primary pulmonary epithelioid sarcoma: a case report
Authors: Mizutani Eiki , Morita Riichiro , Abe Keiko , Kodama Makoto , Kasai Shogo , Okochi Yasumi , Motoi Noriko 
Published: July 2021

Abstract
Background
Epithelioid sarcoma most frequently occurs in the dermal or subcutaneous area of the distal extremities. To date, there have been three cases of primary pulmonary epithelioid sarcoma reported. We report a case of epithelioid sarcoma that is considered a primary lung tumor.

Case presentation
A 65-year-old asymptomatic Asian male patient underwent chest radiography during a routine health examination, and an abnormal mass was detected. His past medical history was unremarkable. He smoked 40 cigarettes every day and had slightly obstructive impairment on spirometry. He worked as an employee of a company and had no history of asbestos exposure. He underwent partial resection of the right lung by thoracoscopy. A histological examination of the tumor revealed a cellular nodule of epithelioid and spindle-shaped cells. Some of the tumor cells displayed rhabdoid features and reticular arrangement in a myxomatous stroma. Immunohistochemically, the tumor cells were positive for vimentin, smooth muscle actin (SMA), CD34, and epithelial membrane antigen (EMA); loss of the BAF47/INI1 protein in the tumor cells was also confirmed. A diagnosis of epithelioid sarcoma was established. Careful screening by whole-body positron emission tomography for another primary lesion after surgery did not detect any possible lesion. He had no cutaneous disease.

Conclusion
To our knowledge, this is the fourth case of a proximal-type epithelioid sarcoma considered as a primary lung tumor.
Disentangled generative adversarial network for low-dose CT
Authors: Du Wenchao , Chen Hu , Yang Hongyu , Zhang Yi 
Published: July 2021

AbstractGenerative adversarial network (GAN) has been applied for low-dose CT images to predict normal-dose CT images. However, the undesired artifacts and details bring uncertainty to the clinical diagnosis. In order to improve the visual quality while suppressing the noise, in this paper, we mainly studied the two key components of deep learning based low-dose CT (LDCT) restoration models—network architecture and adversarial loss, and proposed a disentangled noise suppression method based on GAN (DNSGAN) for LDCT. Specifically, a generator network, which contains the noise suppression and structure recovery modules, is proposed. Furthermore, a multi-scaled relativistic adversarial loss is introduced to preserve the finer structures of generated images. Experiments on simulated and real LDCT datasets show that the proposed method can effectively remove noise while recovering finer details and provide better visual perception than other state-of-the-art methods.
Washback of assessment on English teaching-learning practice at secondary schools
Authors: Rahman Kh. Atikur , Seraj Prodhan Mahbub Ibna , Hasan Md. Kamrul , Namaziandost Ehsan , Tilwani Shouket Ahmad 
Published: July 2021

AbstractThis paper presents the findings of a study which aimed at exploring the washback of the Secondary School Certificate (SSC) English examinations on English teaching and learning practice at secondary schools in Bangladesh. For this purpose, a qualitative research (employing interviews with English teachers, FGDs with students and classroom observations protocol) was conducted in 12 secondary schools. The results from data analysis indicate that the SSC English tests had strong negative washback on English teaching-learning practice at secondary schools resulting from a lack of a congruence between the objectives of the curriculum and the format of the tests, teachers’ lack of adequate understanding about the curriculum and present assessment system, respondents’ negative attitudes towards the test, and pressure from the schools and the parents to ensure good grades in the final examination. Consequently, teachers and learners adopted such teaching and learning approaches which are highly examination-oriented. The study puts forward some suggestions on how positive washback could be generated. The findings of the study have implications for the decision makers, designers of curricula, assessment and testing, teachers, and teacher trainers involved in the Bangladeshi educational system and elsewhere.
Investigating the impact of pre-processing techniques and pre-trained word embeddings in detecting Arabic health information on social media
Authors: Albalawi Yahya , Buckley Jim , Nikolov Nikola S. 
Published: July 2021

AbstractThis paper presents a comprehensive evaluation of data pre-processing and word embedding techniques in the context of Arabic document classification in the domain of health-related communication on social media. We evaluate 26 text pre-processings applied to Arabic tweets within the process of training a classifier to identify health-related tweets. For this task we use the (traditional) machine learning classifiers KNN, SVM, Multinomial NB and Logistic Regression. Furthermore, we report experimental results with the deep learning architectures BLSTM and CNN for the same text classification problem. Since word embeddings are more typically used as the input layer in deep networks, in the deep learning experiments we evaluate several state-of-the-art pre-trained word embeddings with the same text pre-processing applied. To achieve these goals, we use two data sets: one for both training and testing, and another for testing the generality of our models only. Our results point to the conclusion that only four out of the 26 pre-processings improve the classification accuracy significantly. For the first data set of Arabic tweets, we found that Mazajak CBOW pre-trained word embeddings as the input to a BLSTM deep network led to the most accurate classifier with F1 score of 89.7%. For the second data set, Mazajak Skip-Gram pre-trained word embeddings as the input to BLSTM led to the most accurate model with F1 score of 75.2% and accuracy of 90.7% compared to F1 score of 90.8% achieved by Mazajak CBOW for the same architecture but with lower accuracy of 70.89%. Our results also show that the performance of the best of the traditional classifier we trained is comparable to the deep learning methods on the first dataset, but significantly worse on the second dataset.
Evaluation of rebound tonometer iCare IC200 as compared with IcarePRO and Goldmann applanation tonometer in patients with glaucoma
Authors: Nakakura Shunsuke , Asaoka Ryo , Terao Etsuko , Nagata Yuki , Fukuma Yasuko , Oogi Satomi , Shiraishi Miku , Kiuchi Yoshiaki 
Published: July 2021

Abstract
Background
This study investigated the agreement between a new rebound tonometer, IC200, and IcarePRO and Goldmann applanation tonometry (GAT).

Methods
This was a prospective cross-sectional study. We measured the intraocular pressure (IOP) in 145 eyes of 145 glaucoma patients in the sitting position using GAT, IcarePRO, and IC200. IcarePRO and IC200 measurements were also obtained in the supine position. IC200 measurement was performed using two modes: single six (IC200-single) and automatic (IC200-continuous) six-measurements mode.

Results
All tonometers provided high reproducibility in both positions (all intraclass correlation coefficients > 0.90), although it was highest with GAT, followed by IC200-continuous and IC200-single and then IcarePRO. In the sitting position, the mean (± SD) IOPs of GAT, IcarePRO, IC200-single, and IC200-continuous were 14.5 ± 2.9 mmHg, 13.3 ± 3.2 mmHg, 11.6 ± 3.2 mmHg, and 11.5 ± 3.2 mmHg, respectively. IOPs measured with IcarePRO or IC200 were significantly lower than those with GAT, particularly in patients with low IOP. IOPs measured with all tonometers were significantly elevated in the supine position as compared with the sitting position, but this difference was significantly greater with IC200-single and IC200-continuous compared with IcarePRO. IOP elevation was significant in eyes without bleb versus those with bleb, but this finding was not observed when IOP was measured with IcarePRO. The IOPs of the single and continuous modes of IC200 were interchangeable in both positions.

Conclusions
GAT, IcarePRO, and IC200 had sufficiently high reproducibility, but measurements with IcarePRO may not be accurate in the supine position. Elevation of IOP in the supine position, especially in eyes with bleb, was more sensitively captured with IC200 than with IcarePRO.

Trial registration
Japan Clinical Trials Register, No. UMIN000039982.
Evaluation of two microcosm systems for co-treatment of LDPE
oxo
and lignocellulosic biomass for biochar production
Authors: Castillo-Toro Alejandra , Mateus-Maldonado Juan F. , Céspedes-Bernal Diana N. , Peña-Carranza Leonardo , Páez-Morales Adriana I. , Poutou-Piñales Raúl A. , Salcedo-Reyes Juan C. , Díaz-Ariza Lucía A. , Castillo-Carvajal Laura C. , Pedroza-Rodríguez Aura M. , Gómez-Méndez Luis D. 
Published: July 2021

Abstract

Background
The co-transformation of solid waste of natural and anthropogenic origin can be carried out through solid-state-fermentation systems to obtain bio-products with higher added value and lower environmental impact.

Methods

To evaluate the effect of
Pleurotus ostreatus
on co-transformation of oxo-degradable low-density polyethylene (LDPE
oxo
) sheets and lignocellulosic biomass (LCB), were assembled two 0.75 L microcosm systems in vertical (VMS) and horizontal (HMS) position. The pre-treated sheets with luminescent O
2
plasma discharges were mixed with pine bark, hydrolyzed brewer’s yeast and paper napkin fragments and incubated for 135 days at 20 ± 1.0 °C in the presence of the fungus. With the co-transformation residues, biochar (BC) was produced at 300 ± 1.0 °C (BC300) for 1 h, then used to carry out adsorption studies, using the malachite green dye (MG) at pH 4.0, 7.0 and 9.0 ± 0.2. Finally, the biochar was the substrate for the germination of carnation seeds (
Dianthus caryophyllus
) and Ray-grass (
Lolium
sp.) in vitro.

Results

For HMS, the decrease in static contact angle (SCA) was 63.63% (
p
= 0.00824) and for VMS 74.45% (
p
= 0.00219), concerning the pristine. Plastic roughness in VMS was higher (26%) concerning the control. Throughout the 135 days, there were fungal growth and consequently laccase (Lac), manganese peroxidase (MnP) and lignin peroxidase (LiP) activities. During the first 75 days, CO
2
production increased to 4.78 ± 0.01 and 4.98 ± 0.01 mg g-1 for HMS and VMS, respectively. In MG adsorption studies, the highest amount of the colourant adsorbed at both pH 4.0 and 7.0 ± 0.2.

Conclusions

Finally, the biochar or the biochar enriched with low concentrations of plant growth-promoting microorganisms and inorganic fertilizer favours the germination of
Dianthus caryophyllus
and
Lolium
sp., seeds.
Appropriate follow-up period for odontogenic keratocyst: a retrospective study
Authors: Jung Hwi-Dong , Lim Jung-Hwan , Kim Hyung Jun , Nam Woong , Cha In-Ho 
Published: July 2021

Abstract
Purpose
The aim of this study was to conduct epidemiologic investigations on the pattern of the lesion and differences between treatment modalities in terms of recurrence by reviewing follow-up records to form a basis for planning patient follow-up visits.

Materials and methods
In this retrospective, single-center cohort study, 266 patients diagnosed with odontogenic keratocyst between 1993 and 2013 were included. Medical records and radiographic images were analyzed for age distribution, occurrence site and size, treatment modalities, and recurrence.

Results
The average age at first diagnosis was 33.1 years, and the male to female ratio was 1.33:1.00. The highest rate of incidence was in the third decade followed by the fourth, second, and fifth decades. The incidence in the maxilla was 34%, and 66% in the mandible. Mandibular ramus was most commonly involved. Lesions between 3 and 6 crowns were the most common, and the rate of recurrence increased with size. Enucleation after decompression had higher rate of recurrence (35.8%) than enucleation (27.1%), but there was no statistical significance.

Conclusion
The recurrence of odontogenic kerotocyst (OKC) was significantly associated with large size, multilocular form, and surgical procedure. A 10-year follow-up period is recommended to determine any recurrence of OKC.
A cannabis oracle? Delphi method not a substitute for randomized controlled trials of cannabinoids as therapeutics
Authors: Hill Kevin P. , Abrams Donald I. 
Published: July 2021

Abstract
Background
With millions of people using cannabinoids to treat a host of medical conditions, clinicians want guidance on how to utilize cannabinoids as pharmacotherapy in their practices. The Delphi method is a systematic, interactive forecasting method that aims to develop consensus best practices where guidelines are not available.

Body
A multidisciplinary group of global cannabinoid experts utilized a modified Delphi process to develop three protocols for the dosing and administration of cannabinoids to treat chronic pain. Two protocols recommend cannabidiol (CBD), for which there is limited evidence as an analgesic, starting well below doses required for other indications. Guidance on prescribing CBD for pain may demonstrate consensus recommendations based upon suboptimal evidence.

Conclusion
Consensus processes like the Delphi method are well-meaning, but they are not a substitute for rigorous RCTs with large sample sizes, adequate duration, and standardized outcome measures.