bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of 11C-Choline PET/CT-Based Multi-Metabolic Parameter Combination in Distinguishing Early-Stage Prostate Cancer From Benign Prostate Diseases
Authors: Zhou Shuoming , Fu Hongliang , Liu Changming , Zhu Ziqiang , Zhang Jiabin , Weng Wubin , Kang Jian , Liu Qiang 
Published: February 2021

PurposeThe most common disadvantage of 11C-choline positron emission tomography and computed tomography (PET/CT) in diagnosing early-stage prostate cancer (PCa) is its poor sensitivity. In spite of many efforts, this imaging modality lacks the ideal parameter of choline metabolism for the diagnosis of PCa, and the single metabolic parameter, that is, maximal standardized uptake value (SUVmax), based on this imaging modality is insufficient. 11C-choline PET/CT-based multi-metabolic parameter combination can help break this limitation.Materials and MethodsBefore surgery, SUVmax of choline, which is the most common metabolic parameter of 11C-choline PET/CT, mean standardized uptake value (SUVmean), prostate-to-muscle (P/M) ratio, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) from 74 patients with histologically proven PCa were quantified. A total of 13 patients with focal chronic prostatitis without severe features and 30 patients with benign prostate hyperplasia were used for comparison. Univariable and multivariable analyses were performed to compare the patient characteristics and metabolic parameters of 11C-choline PET/CT. The performance of single parameters and the combination of parameters were assessed by using logistic regression models.ResultsThe comparable c-statistics, which mean the area under the ROC curve in the logistic regression model, of SUVmax, SUVmean, and P/M ratio are 0.657, 0.667, and 0.672, respectively. The c-statistic significantly rose to 0.793 when SUVmax and SUVmean were combined with the P/M ratio. This parameter combination performed the best for PCa cases with all biochemical recurrence risks and for PCa patients grouped by different risk. The greatest improvement over a single parameter, such as P/M ratio, was noted in the group of low-risk PCa, with values of 0.535 to 0.772 for the three-parameter combination. And in the histopathological level, the Ki-67 index is positively correlated with the P/M ratio (r=0.491, p=0.002).ConclusionP/M ratio is a more ideal parameter than SUVmax as a single parameter in early-stage PCa diagnosis. According to our data, the combination of SUVmax, SUVmean, and P/M ratio as a composite parameter for diagnosis of early stage PCa improves the diagnostic accuracy of 11C-choline PET/CT.
Weighted-Support Vector Machine Learning Classifier of Circulating Cytokine Biomarkers to Predict Radiation-Induced Lung Fibrosis in Non-Small-Cell Lung Cancer Patients
Authors: Yu Hao , Lam Ka-On , Wu Huanmei , Green Michael , Wang Weili , Jin Jian-Yue , Hu Chen , Jolly Shruti , Wang Yang , Kong Feng-Ming Spring 
Published: February 2021

BackgroundRadiation-induced lung fibrosis (RILF) is an important late toxicity in patients with non-small-cell lung cancer (NSCLC) after radiotherapy (RT). Clinically significant RILF can impact quality of life and/or cause non-cancer related death. This study aimed to determine whether pre-treatment plasma cytokine levels have a significant effect on the risk of RILF and investigate the abilities of machine learning algorithms for risk prediction.MethodsThis is a secondary analysis of prospective studies from two academic cancer centers. The primary endpoint was grade≥2 (RILF2), classified according to a system consistent with the consensus recommendation of an expert panel of the AAPM task for normal tissue toxicity. Eligible patients must have at least 6 months’ follow-up after radiotherapy commencement. Baseline levels of 30 cytokines, dosimetric, and clinical characteristics were analyzed. Support vector machine (SVM) algorithm was applied for model development. Data from one center was used for model training and development; and data of another center was applied as an independent external validation.ResultsThere were 57 and 37 eligible patients in training and validation datasets, with 14 and 16.2% RILF2, respectively. Of the 30 plasma cytokines evaluated, SVM identified baseline circulating CCL4 as the most significant cytokine associated with RILF2 risk in both datasets (P = 0.003 and 0.07, for training and test sets, respectively). An SVM classifier predictive of RILF2 was generated in Cohort 1 with CCL4, mean lung dose (MLD) and chemotherapy as key model features. This classifier was validated in Cohort 2 with accuracy of 0.757 and area under the curve (AUC) of 0.855.ConclusionsUsing machine learning, this study constructed and validated a weighted-SVM classifier incorporating circulating CCL4 levels with significant dosimetric and clinical parameters which predicts RILF2 risk with a reasonable accuracy. Further study with larger sample size is needed to validate the role of CCL4, and this SVM classifier in RILF2.
A Central Clearing Clinic to Provide Mental Health Services for Refugees in Germany
Authors: Bajbouj Malek , Panneck Patricia , Winter Sibylle-Maria , Ajami Carlos , Alabdullah Jihad , Benedikt Burger Max , Haberlandner Anja , Hahn Eric , Heinz Andreas , Heuser Isabella , Hoyer Armin , Kluge Ulrike , Aichberger Marion , Repantis Dimitris , Schreiter Stefanie , Seybold Joachim , Sutej Igor 
Published: February 2021

Objective: To determine migration related distress pattern in refugees and feasibility of a de novo established, central low-threshold outpatient clinic serving more than 80,000 newly arrived refugees in the metropole of Berlin.Methods: In an observational cohort study the relative prevalence of major psychiatric disorders by age, place of living within berlin, language and region of origin were assessed in a refugee cohort from 63 nationalities speaking 36 languages.Findings: Within 18 months, a total of 3,096 cases with a mean age of 29.7 years (11.7) have been referred from all 12 districts and 165 of 182 subdistricts of Berlin to the CCC. 33.7% of the patients were female. The three most frequent diagnoses were unipolar depression (40.4%), posttraumatic stress disorder (24.3%), and adjustment disorder (19.6%).Conclusion: The present data gives insight into the distribution of mental disorders in a large sample of refugees and provides evidence that a CCC is an effective service to quickly and broadly provide psychiatric consultations and thus to overcome classical barriers refugees usually experience in the host communities. In Berlin, Germany, and Europe treatment resources for this population should focus on stress and trauma related disorders.
REVITALIZAÇÃO DE CORPOS DÁGUA COM O USO DA BIORREMEDIAÇÃO
Authors: Souza Luís Henrique Nunes de , Arruda Regina De Oliveira Moraes 
Published: February 2021

Água é a principal e essencial fonte de vida, indispensável para há vida como compreendemos, com está mentalidade de preservação da vida e das águas, métodos como biorremediação foram desenvolvidas para tratar algumas dessas fontes de vida ou tratar contaminações nas massas de água. O objetivo deste trabalho foi revitalizar a massa dagua presente no interior do Zoológico Município de Guarulhos  SP, por meio de técnicas de Biorremediação. Para alcançar os objetivos propostos foi realizados métodos de biorremediação mediante, bioaumentação por meio de um misto de bactérias heterotróficas, bolores e leveduras e bioestimulação por equipamentos do laboratório. As coletas obedeceram aos parâmetros de preservação e transporte, estabelecidos pela Agência Nacional de Águas. Foram analisadas as variáveis; condutividade elétrica (CE), clorofila a (CL), coliformes termotolerantes (CF), demanda bioquímica de oxigênio (DBO), nitrogênio total (NT), oxigênio dissolvido (OD), pH, Fósforo total (PT), sólidos totais (ST), temperatura (T) e Turbidez (TU). Foram calculados o índice de qualidade das águas (IQA) e do índice do estado estrófico (IET). O tratamento foi feito por 7 dias na Incubadora a 30ºC/ 135 rpm. Dentre os métodos avaliados tanto a bioaumentação como a biorremediação com um produto comercial (composto por bactérias heterotróficas, bolores e leveduras, bactérias anaeróbicas facultativas) não apresentou efeito sobre a eutrofização e qualidade geral das águas do lago estudado, nas condições estudadas. Novos estudos com diferentes biorremediadores devem ser realizados a fim de solucionar o problema de lagos urbanos eutrofizados
Potencial Espeleoturístico das grutas do Circuito do Pião, Parque Estadual do Ibitipoca (MG)
Authors: Costa Bruno Diniz , Fonseca Filho Ricardo Eustáquio , Lobo Heros Augusto Santos 
Published: February 2021

O Parque Estadual do Ibitipoca (MG) é conhecido por suas cachoeiras e cursos d’água com coloração peculiar, bem como diversas cavernas turísticas e um potencial espeleológico a ser explorado. Neste contexto, torna-se necessário avaliar o potencial espeleoturístico das grutas abertas à visitação, a fim de atualizar as informações e percepções sobre sua conservação. A pesquisa realizada avaliou o potencial espeleoturístico das grutas do Circuito do Pião (Monjolinho, Viajantes e Pião), considerando suas fragilidades intrínsecas e potencialidades de uso. Assim, foi possível identificar os fatores condicionantes e limitantes à visitação turística nas três cavernas, apresentando resultados que podem contribuir com a gestão do parque. A interpretação dos resultados sugere a revisão da possibilidade de visitação da gruta do Pião, a limitação do uso público da gruta do Monjolinho e apresenta um alto potencial espeleoturístico para a gruta dos Viajantes, a qual necessita de intervenções de manejo que contribuam para o ordenamento da visitação turística.
Innovating Vocational Resilience: Getting a Second Start at Work through the Ignatian Examen
Authors: McMillin Stephen Edward 
Published: February 2021

The Ignatian Examen is a tool that can build vocational resilience for social workers. It has five components: 1) praying for light or becoming aware of the presence of God, 2) gratefully reviewing the events of the day, 3) reviewing the feelings and emotions that surface when events are brought to mind, 4) choosing one of those feelings, either positive or negative, and praying from it, and 5) looking toward the future. Although it is often used as a bedtime prayer, St. Ignatius of Loyola designed the Examen to occur twice, at noon and after supper, with an additional remembrance of the evening Examen upon rising. The noon Examen may actually be the most important practice to build vocational resilience for social workers because the noon Examen allows for calming the workday and for making course corrections and attitude adjustments as needed.
ДИНАМІКА ЕЛЕМЕНТІВ РОБОЧИХ КЛІТЕЙ АВТОМАТИЧНОГО СТАНУ ТПА 350
Authors: Rakhmanov Suleiman , Povorotniy Viktor 
Published: February 2021

Цель работы. Разработка математической модели динамической системы «гильза (труба)- рабочая клеть» с её последующим обоснованием и исследование амплитудно-частотных характеристик вертикальных колебаний рабочих валков с учетом влияния изменения во времени технологической нагрузки прокатываемой гильзы, масс механической системы и жесткости базовых элементов рабочей клети автоматического стана ТПА 350.Методика. Теоретические исследования динамики элементов рабочей клети автоматического стана ТПА 350 проведены с использованием фундаментальных закономерностей и аналитических методов механики, динамики механических систем с упругими звеньями, теории колебаний, теории машин и механизмов, метода конечных элементов. Имитационное исследования перемещения установки рабочих валков выполнялось на основе разработанных математических моделей с помощью численных методов решения дифференциальных уравнений с использованием современных информационных технологий. Экспериментальные методы диагностики энергосиловых параметров автоматического стана ТПА 350 прокатки были проведены с использованием тензометрического метода, при помощи сертифицированной измерительной и регистрирующей аппаратуры.Результаты. Расчетным путем установлено, что максимальная амплитуда вынужденных колебаний элементов рабочей клети автоматического стана ТПА 350 в межвалковом пространстве достигает более 2 мм. Это намного превышает допустимые величины настроечных параметров очага деформации автоматического стана ТПА 350.Научная новизна. Разработана модель динамики межвалкового пространства автоматического стана ТПА 350, что позволило в комплексе оценить амплитудно-частотные характеристики ветвей рабочей клети, с учетом изменения жесткости подшипников опорных узлов установки валков во времени и нестационарной технологической нагрузки со стороны очага деформации.Практическое значение. Предложена схема комплексной модернизации установки валков рабочей клети автоматического стана ТПА 350. Достигнуто повышение жесткости установки валков рабочей клети автоматического стана ТПА 350, что обеспечивает стабилизацию амплитуды вынужденных колебаний элементов рабочей клети и снижение разностенности прокатываемых гильз. В целом, это приводит к повышению качества прокатываемых труб на ТПА 350.
ПЕЧІ З ЕЛЕКТРОТЕРМІЧНИМ КИПЛЯЧИМ ШАРОМ. КОНСТРУКТИВНІ ОСОБЛИВОСТІ
Authors: Sybir Artem , Hubynskyi Mykhailo , Fedorov Serhii , Hubynskyi Semen , Gogotsi Olexey 
Published: February 2021

Мета: Метою статті є критичний аналіз та систематизація печей з електротермічним киплячим шаром, які використовуються у низько- та високотемпературних технологічних процесах у металургійній та хімічний промисловості., а також визначення конструктивних особливостей цих пічних агрегатів.Методика: Критичний аналіз конструкцій високотемпературних установок з електротермічним киплячим шаром на основі світового доробку в галузі графітації та рафінування вуглецевих матеріалів з метою отримання високочистого батарейного графіту.Результати: За результатами проведеного дослідження та критичного аналізу літературних джерел, авторами запропонована класифікація електротермічних печей киплячого шару: за температурним режимом – низько- та високотемпературні установки; та за на напрямом руху електричного струму між електродами печі крізь шар оброблюваного матеріалу – агрегати із горизонтальним та вертикальним рухом струму. Визначено відмінні особливості у схемах підведення газу та проаналізовано способи завантаження / вивантаження матеріалу.Наукова новизна: Вперше визначено взаємозв’язок можливих конструктивних характеристик електротермічних печей киплячого шару з температурним режимом їх експлуатації.Практична цінність: Результати роботи являють собою систематизований науково-технічний матеріал корисний для науковців, дослідників та інженерів задіяних в розробці нових технологій та експлуатації наявних пічних установок на основі електротермічного киплячого шару.
Inquérito soroepidemiológico para toxoplasmose, leptospirose e leishmaniose visceral canina
Authors: Bott Mantovan Karine , Grave Saraiva Luiz Christiane , Menozzi Benedito Donizete , Guimarães Nilsson Mariana , Soares Latosinski Giulia , Langoni Helio 
Published: February 2021

Com o aumento da ocorrência de zoonoses emergentes e reemergentes, o cão desempenha papel relevante como reservatório de algumas delas, destacando-se assim o seu papel como animal sentinela para o estudo de várias doenças comuns entre humanos e animais. Buscou-se avaliar o potencial zoonótico da população canina investigando a soroprevalência de anticorpos para toxoplasmose, leptospirose e leishmaniose visceral em 181 cães do Município de Pardinho, SP. Analisou-se as variáveis epidemiológicas como idade, sexo, situação vacinal, ambiente em que vivem, se há rede de água e de esgoto, livre acesso à rua, presença de roedores, e se os tutores deixam a alimentação dos animais à disposição no período noturno que são fatores de risco para a ocorrência dessas enfermidades. Trata-se de um estudo transversal do tipo inquérito soroepidemiológico. As amostras de soro foram obtidas no momento da castração realizada por Médico Veterinário no Programa de Controle Populacional realizado pelo Serviço de Vigilância do município. Foram submetidas a reação de imunofluorescência indireta (RIFI) para detecção de anticorpos da classe IgG anti-Toxoplasma gondii e anti-Leishmania chagasi bem como anticorpos anti-Leptospira spp, para vários sorovares de leptospiras pela técnica de soroaglutinação microscópica (SAM). Encontrou-se 7 (3,87%) de soropositividade para leptospirose, sendo o sorogrupo de maior prevalência o Canicola (71,42%), seguido do Icterohaemorrhagiae (14,29%) e Pyrogenes (14,29%). Para pesquisa de anticorpos anti-Toxoplasma gondii 17 animais foram positivos, com título 16 (47,05%), 64 (41,17%), 256 (5,89%) e titulo 4096 em (5,89%). As amostras testadas para leishmaniose visceral canina foram todas negativas. A análise estatística foi realizada com o software SAS OnDemand of Academics em nível de significância de 0,05 e as associações entre as variáveis epidemiológicas ambos pelo Teste de Fisher, porém não houve relação estatística significante entre elas, pois o nível de significância foi maior que 0,05.
ANALISIS SALURAN DAN MARGIN PEMASARAN MANGGIS STUDI KASUS DI KELOMPOK TANI MANGGISTA DESA CIBOKOR KECAMATAN CIBEBER KABUPATEN CIANJUR
Authors: Alam Asep Saepul , Susanto Agus Himawan 
Published: February 2021

Salah satu Kecamatan yang menjadi sentra produksi Buah Manggis adalah Kecamatan Cibeber Kabupaten Cianjur. Penelitian dilakukan di Kelompok tani Manggista Desa Cibokor, Kecamatan Cibeber, Kabupaten Cianjur. Dimulai pada Bulan April sampai dengan Juli 2019 dengan tujuan untuk : 1) Untuk mengetahui pola saluran pemasaran Buah Manggis Kelompok Tani Manggista Desa Cibokor, Kecamatan Cibeber, Kabupaten Cianjur. 2) Untuk mengetahui besar margin pemasaran Buah Manggis untuk masing-masing saluran pemasaran. Penelitian ini menggunakan teknik purposive sampling dan snowball sampling dalam penentuan tempat dan responden. Hasil penelitian menunjukkan bahwa : 1. Pola saluran pemasaran buah manggis di Kelompok Tani Manggista, yakni : 1). Kelompok tani Manggista → pengepul → konsumen, 2). Kelompok tani Manggista → pengepul → pengecer → konsumen (Bogor). 2. Besar margin pada saluran pemasaran I sebesar Rp.2.000-, besar margin pada saluran pemsaran II sebesar Rp.7.400-,. Diketahui untuk pemasaran buah Mangis memiliki R/C sebesar 1,81,didapatkan dari Harga jual sebesar Rp.12,400 dibagi dengan jumlah biaya pemasaran yaitu Rp.6.850 maka di dapatkan Nilai R/C ratio sebesar 1.81. Sedangkan Farmer’s share yang paling efisien berada di saluran pemasaran I yaitu 71,45%.
PENGARUH KEASLIAN DAN MEREK TERHADAP HARGA DAN KEPUASAN KONSUMEN BERAS PANDANWANGI CIANJUR
Authors: Ahmad Muhammad Yahya 
Published: February 2021

Beras Pandanwangi Cianjur merupakan beras khusus dengan merek yang sama dengan nama berasnya yang diproduksi di Kabupaten Cianjur yang merupakan indikasi geografis bagi wilayah tersbut. Dengan merek yang sudah menjadi reputasi dalam pemasaran, beras ini menghadapi permasalah terkait dengan persaingan dagang dengan penggunaan nama merek yang tidak menguntungkan bagi petani produsen beras pandanwangi. Penelitian ini dilakukan pada bulan Maret sampai dengan bulan Juni 2019 bertujuan untuk mengukur sampai sejauh mana pengaruh keaslian beras pandanwangi dan penggunaan merek terkait teradap harga dan kepuasan konsumennya. Sebanyak 85 responden yang merupakan konsumen beras pandanwangi di Cianjur dilibatkan dalam penelitian ini. Pengumpulan data dilakukan dengan aplikasi kuesioner yang berisikan variabel penelitian yang terdiri dari keaslian beras (originality), merek (brand), harga (price) dan klepuasan konsumen (cunsumer satisfaction). Data yang diperoleh diolah menggunakan model persamaan struktural (Structural Equation Modeling, SEM) dari Amos versi 21.Hasil penelitian menunjukkan bahwa jaminan keaslian atau originalitas beras pandanwangi akan mampu pendongkrak harga jual. Keaslian beras pandanwangi, tentu saja diperoleh dari padi pandanwangi yang murni merupakan alasan penting jika petani menginginkan harga jual yang tinggi. Selanjutnya, harga beras pandanwangi memiliki pengaruh yang signifikan terhadap kepuasan konsumen. Hal ini mengindikasikan bahwa kepuasan pelanggan dapat dibangun melalui harga beras, dengan kata lain kepuasan konsumen akan terjadi untuk beras dengan harga tinggi karena secara prikologis jika beras pandanwangi dijual dengan harga murah akan memiliki efek psikologis negatif terhadap kepercayaan keasliannya. Hasil lain penelitian ini menunjukkan bahwa keaslian dan merek beras pandanwangi tidak berpengaruh secara langsung kepada kepuasan konsumennya. Namun sebaliknya, merek beras pandanwangi memiliki pengaruh yang signifikan kepada harga jual. Dengan kata lain merek beras pandanwangi memiliki kekuatan atau daya tawar yang kuat dalam pemasaran beras pandanwangi.
PENGARUH SISTEM KEMITRAAN INTI-PLASMA TERHADAP JAMINAN PASAR, KUALITAS BAGLOG JAMUR TIRAM PUTIH DAN KEPUASAN PETANI DI CV. ASA AGRO CORPORATION KECAMATAN CUGENANG KABUPATEN CIANJUR
Authors: Suryana Adang , Rizqi Ginia Sri 
Published: February 2021

Jamur tiram putih adalah salah satu sayuran bergizi yang telah dibudidayakan dan memiliki kandungan nutrisi yang lebih tinggi dibandingkan dengan jenis jamur lainnya. CV. Asa Agro Corporation produk jamur tiram ini dan perusahaan ini telah menciptakan sistem kemitraan inti plasma yang berlokasi di Kecamatan Cugenang, Kabupaten Cianjur. Berdasarkan peraturan kemitraan, sebagaimana diatur dalam Peraturan Pemerintah Nomor 44 Tahun 1997: "kemitraan inti-plasma adalah kerjasama antara usaha kecil dengan menunjukkan prinsip-prinsip saling membutuhkan, saling menguatkan dan saling menguntungkan". Tujuan dari penelitian ini adalah untuk mengetahui Pengaruh Sistem Mitra Usaha terhadap Jaminan Pasar, dan Pengaruh Sistem Mitra Usaha terhadap Kepuasan Petani Plasma, dan Pengaruh Sistem Mitra Usaha terhadap Kualitas Jamur Tiram Baglog, dan Pengaruh Sistem Mitra Usaha Terhadap Kepuasan Petani Plasma Melalui jaminan pasar, seiring dengan Pengaruh Sistem Mitra Usaha terhadap Kepuasan Petani Plasma Melalui Kualitas Baglog Jamur Tiram. Penelitian ini menerapkan metode survei menggunakan kuesioner dan dokumentasi. Populasi dan sampel yang digunakan dalam penelitian ini sebanyak 60 responden, mereka semua yang bergabung dengan kemitraan. Penelitian ini menggunakan Structural Equation Models (SEM) untuk analisis data. Hasil penelitian ini menunjukkan bahwa sistem kemitraan inti-plasma memiliki pengaruh yang signifikan pada jaminan pasar, dan sistem Kemitraan inti-plasma memiliki pengaruh yang signifikan pada kepuasan petani plasma, dan sistem kemitraan inti-plasma memiliki pengaruh yang signifikan pada kualitas baglog jamur tiram dan tidak memiliki pengaruh langsung dari sistem kemitraan plasma inti pada kepuasan petani plasma melalui jaminan pasar tidak signifikan dan sistem kemitraan inti-plasma memiliki pengaruh langsung pada kepuasan petani plasma melalui kualitas baglog jamur tiram signifikan.