bluuebunny/crossref_metadata_2025_split huggingface dataset:
NI-18 A Quantitative Analysis of Intraoperative 3T-Diffusion Tensor Imaging parameters for Functional Prediction with Motor Eloquent Glioma Patients
Authors: Kawataki Tomoyuki , Hanihara Mitsuto , Ogiwara Masakazu , Kinouchi Hiroyuki 
Published: December 2021

Abstract
OBJECTIVE: In motor eloquent glioma surgery, the value of intraoperative diffusion tensor (iDT) imaging was not established to preserve motor function. This study aimed to investigate a relationship between postoperative motor function and iDT imaging parameters, including fractional anisotropy (FA), mean diffusivity (MD), and shortest distance (SD) from resected tumor margin to the corticospinal tract (CST) of gliomas in motor eloquent areas. METHODS: This retrospective study enrolled 20 patients with newly diagnosed supratentorial glioma who underwent surgery and intraoperative magnetic resonance imaging at our hospital. Patients were divided into two groups (i.e., worsening and non-worsening groups) based on their manual muscle test scores before and three months after surgery. We obtained the mean FA and MD values bilaterally, along with identification of the CST and determined the ratios (the affected side / the contralateral side). The SD was measured between the CST and the resected margin of the tumor. We evaluated the quantitative analysis of these parameters related to motor functional outcomes. Moreover the correlation was measured between these parameters and the maximum reduction rate of cortical motor evoked potentials (MEPs) during surgery. RESULTS: In the worsening group (n = 5), the mean FA ratio was lower and the mean MD ratio was higher compared with the non-worsening group (n = 15; P &lt; 0.001 and P &lt; 0.01, respectively). Cut-off values were 0.87 for FA and 1.08 for MD. SD was 7.95 mm in the non-worsening group and 0.44 mm in the worsening group (P &lt; 0.01). These iDT based parameters, the mean FA ratio and the SD, were well correlated with the maximum reduction rate in MEP (R = 0.72 and 0.80, respectively). CONCLUSIONS: The mean ratio of FA, MD, and SD using iDT imagings predict postoperative motor function and help in optimal surgical planning in patients with motor eloquent glioma.
NQPC-2 Cognitive function of a low-grade glioma patient treated with radiation therapy 28 years ago
Authors: Yamada Kazuki , Ideguchi Makoto , Matsutani Masao 
Published: December 2021

Abstract
While there are many reports that long-term survivors of low-grade glioma patients treated with radiation therapy cannot lead a healthy social life due to cognitive dysfunction, we report a low-grade glioma patient with almost normal cognitive function even after radiation therapy 28 years ago. CASE REPORT. A 64-year-old woman developed with sudden left hemiparesis and was diagnosed as a small infarction in the left corona radiata. After treated by anticoagulant therapy, she was admitted to our hospital for rehabilitation. Twenty-eight years ago, she underwent surgical resection and radiation therapy with 60 Gy for astrocytoma (WHO grade 2) in the right insular cortex. At the time of this admission, she presented with a good MMSE score of 30 points, but she couldn’t walk and her left hand was less maneuverable. After 109 days of intensive rehabilitation in our hospital, she was discharged on a cane walk, and returned to work as a gas station clerk. COGNITIVE FUNCION. We evaluated her cognitive function on TMT-A/B test, CAT (Clinical Assessment for Attention)and WAIS-4. The TMT test was normal with age adjustments. In CAT, the percentage of correct answers for the 7 constituent items was within the standard range, but in the task of evaluating the required time, a slight delay in processing speed was observed. In WAIS-4, the Full scale IQ was 98 points (normal range) including normal 3 of 4 constituent items. But, only the PSI (processing speed) of 75 point was below the standard range. CONCLUSION: We observed a slight delay in processing speed on her high-level cognitive function tests, but determined that she would be well-adapted to a familiar job in a small community. In fact, she was doing well on the job 10 months after her discharge.
ML-11 Tirabrutinib treatment for recurrent or refractory PCNSL
Authors: Ohka Fumiharu , Yamaguchi Junya , Motomura Kazuya , Aoki Kosuke , Nishikawa Tomohide , Kibe Yuji , Yamazaki Shintaro , Natsume Atsushi , Saito Ryuta 
Published: December 2021

Abstract
Since 2020, tirabrutinib which is a Bruton’s tyrosine kinase (BTK) inhibitor has been available for recurrent or refractory PCNSL cases. The number of studies reporting efficiency and adverse effect of tirabrutinib treatment for recurrent or refractory PCNSL has been limited yet. In this study, we investigated clinical course of eight refractory or recurrent PCNSL cases treated with tirabrutinib in our institute.
Eight PCNSL cases treated with tirabrutinib included four recurrent cases and four refractory cases. Five cases obtained CR or PR after 26.8 days administration of tirabrutinib and other two cases also exhibited obvious improvement of clinical symptoms after 23.5 days administration of tirabrutinib. Among three cases exhibiting intraocular lesions, two cases revealed improvement of visual dysfunction and the other case obtained SD status of intraocular lesion. The most frequently found adverse effect was the skin rash. CTCAE grade 2 (n=2) or 3 (n=2) rash was found after mean 16 days or 94 days of tirabrutinib administration, respectively. Two cases with grade 3 rash could start taking the low-dose tirabrutinib after improvement of rash. Althouth one case experienced shingles, no other case experienced serious adverse effects.
Although adverse effect of rash was frequently found, we could obtain high response rate of tirabrutinib treatment for recurrent or refractory PCNSL cases. We need to establish quantitative assessment method for analysis of treatment response of tirabrutinib for intraocular lesions.
MET-4 Clinical investigation of the cases recurred as dissemination after postoperative local irradiation for metastatic brain tumors
Authors: Hashiba Tetsuo , Ueno Katsuya , Naito Nobuaki , Yamamura Natsumi , Komori Yumiko , Isozaki Haruna , Lee Ichi , Kamei Takamasa , Takeda Junnichi , Yoshimura Kunikazu , Nonaka Masahiro , Asai Akio 
Published: December 2021

Abstract
Last year, the authors examined the outcome of the patients with metastatic brain tumor (MBT)treated by whole-brain irradiation (WBRT)or local irradiation (LRT)after surgery. As a result, it was shown that the overall survival (OS) was same but the recurrence pattern was different. Furthermore, it was shown that there were some cases with disseminated recurrence in the LRT group. One year has passed, cases showing disseminated recurrence after LRT were examined. The subjects were 28 patients for whom LRT was selected as post-surgical irradiation since December 2017, with an average age of 66.2 years and a male-female ratio of 19: 9. Non-small cell lung cancer was the most in 17 cases. During the observation period, recurrence was observed in 12 cases, new outbreaks at other sites in 8 cases, disseminated recurrence in 4 cases, and no local recurrence. There was no clear difference in kinds of carcinoma and removal fashion between disseminated recurrence cases and other cases. Disseminated recurrence occurred between 3–10 months after surgery, 2 presented with headache, 1 with convulsions, 1 confirmed during follow-up of images, and all underwent WBRT. The lesions shrank after irradiation, but they were easy to re-grow, and the prognosis was poor. On the other hand, 10 cases died in 24 cases other than disseminated recurrence, but all cases died of primary cancer. Although LRT after surgery is non-inferior to WBRT in terms of OS and has the advantage of maintaining cognitive function, this study shows that there is a considerable risk of disseminated recurrence regardless of the removal fashion or kinds of carcinoma. It was also shown that prognosis after disseminated recurrence was poor. It is desirable to select postoperative irradiation after explaining the recurrence pattern, and when LRT is adopted, it is necessary to consider setting a short observation interval immediately after irradiation.
MET-8 Chemotherapy alone for brain metastases from small cell lung cancer -comparison with EGFR-TKI-
Authors: Iuchi Toshihiko , Syngyoji Masato , Ashinuma Hironori , Mizuno Satoko , Hasegawa Yuzo , Setoguchi Taiki , Hosono Junji , Sakaida Tsukasa 
Published: December 2021

Abstract
Background: Because of the invasive nature of small cell lung cancer (SCLC), the effectiveness of local therapy for brain metastases (BM) from SCLC had been limited. In this article, we retrospectively evaluated the efficacy of chemotherapy against non-treated BM from SCLC (SCLC-CHT) in compared with TKI for BM from EGFR-mutated NSCLC (EGFR-TKI).Materials and Methods: Un-treated 218 BM, including 58 SCLCs and 160 EGFR-mutated NSCLCs were enrolled. The primary endpoints were maximum response of BM and the duration of effect, and the secondary endpoints were times to the first and maximum responses, patterns of progression and overall survival after the diagnosis of BM.Results: The objective response rate (69%) and disease control rate (92%) of BM after SCLC-CHT were inferior to those after EGFR-TKI (85%, 97%), but were sufficiently satisfactory. Both the times to the first response (0.8m, 95% CI:0.6–0.9) and to the maximum effect after treatment(1.6m, 0.9–1.9) with SCLC-CHT were shorter than with EGFR-TKI (0.9m,0.9–1.0, P=0.011, and 2.4m, 1.9–2.8, P=0.004), but the duration of the response was conversely shorter with SCLC-CHT (5.1m, 4.2–5.6) than with EGFR-TKI (12.3m,9.2–15.1, P&lt;0.0001). The dominant pattern of recurrence was local progression in the both groups. The risk of local progression after SCLC-CHT was higher than after EGFR-TKI (Fine-Gray HR:2.44, 1.56–3.83, P&lt;0.0001), although the risk of new BM was not different between these two groups (0.94, 0.49–1.82, P=0.86). The risk of non-CNS death was higher after SCLC-CHT than after EGFR-TKI (1.8, 1.2–2.7, P=0.004), but the risk of CNS death was not different (0.92, 0.45–1.89,P=0.83).Conclusions: BM from SCLC well and quickly responded to CHT, but the duration of response was short. These responses of BM against CHT was comparable to that of extracranial disease. For the better control of BM and survival of patients, ingenuity to prolong the effect of CHT is required.
CS-7 A case of Lymphomatoid granulomatosis with skin, lung, and intracranial lesions due to multicentric development
Authors: Komaki Satoru , Furuta Takuya , Negoto Tetsuya , Moritsubo Mayuko , Nakamura Hideo , Sugita Yasuo , Morioka Motohiro 
Published: December 2021

Abstract
Introduction: LYG is very rare tumor and composed of large EB-positive B cells and reactive T cells. In this study, we experienced a case of LYG with multiple intracranial, cutaneous, and pulmonary masses. We report the pathogenesis and pathophysiology of LYG, including a discussion of the literature. case: A 69-year-old female presented with a growing lump in her lower back that had been present for several years. Six months later, she was found to have multiple masses in her lungs and intracranial region and underwent surgical removal for diagnostic purposes. Intraoperative findings: The tumor was substantial, reddish to grayish-white in color, and the margins of the tumor were whitish and hard, with some areas that could not be detached. Pathological findings: There were no atypical lymphocytes, and a small number of EBER-positive cells were observed. IgVH PCR: IgVH PCR was performed on the skin lesions and intracranial lesions, and bands of different sizes were detected, suggesting that the IgVH clone was present in the polyclonal region. Finally, we diagnosed LYG grade 1. discussion: EB-associated lymphoproliferative disease can lead to polyclonal reactive growth or monoclonal neoplastic growth depending on the balance between morphology and host immunity. The results of IgVH PCR suggest that the skin lesions did not cause multiple metastases, but rather that the enlargement of the skin lesions triggered intracranial and pulmonary lesions in an allo-centric manner. The results of IgVH PCR suggested that the skin lesions did not cause multiple metastases, but rather that the skin lesions grew to cause intracranial and pulmonary involvement in an other-centric manner.
COT-1 Clinical Questions and Answers about Glioma-Related Epilepsy (GRE): Real-world data in Wakayama Medical University Hospital
Authors: Fukai Junya , Sasaki Takahiro , Yamoto Toshikazu , Nakai Yasuo , Ishii Masamichi , Kitayama Mari , Nishibayashi Hiroki , Mori Kanji , Kanemura Yonehiro , Nakao Naoyuki 
Published: December 2021

Abstract
Introduction: In glioma patients, epilepsy not infrequently occurred and anti-epileptic drugs (AEDs) are commonly used. In this study, we revealed the real-world data on clinical practice of glioma-related epilepsy in Wakayama Medical University Hospital (WMUH). Methods. We collected clinical and molecular data of glioma patients operated at WMUH from January 1996 to December 2020 and analyzed the data to answer clinical questions as follows: 1) location/histology related GRE, 2) molecular features related GRE, 3) prophylactic AEDs and postoperative seizure, 4) tumor progression and convulsion, 5) GRE and survival. Results. Fifty-five of 113 glioma patients (49%) presented with seizure. CQ1. In tumors located at frontal, temporal and parietal lobe, the occurrence rate of GRE was 27/39 (69%), 13/19 (69%) and 9/14 (64%), respectively. Patients with glioblastoma, astrocytic tumors and oligodendroglial tumors presented with GRE at the rate of 26/54 (48%), 14/30 (47%) and 12/13 (92%), respectively. CQ2. GRE occurred in tumors with IDH mutated (16 cases, 29%), TERT mutated (32 cases, 58%) and MGMT methylated (32 cases, 58%). CQ3. Seizure in peri- or postoperative period occurred in 14 cases (12%); 4 cases in AED(+) group (4/29, 14%) and 10 cases in AED(-) group (10/84, 12%). CQ4. Tumor progression became apparent at the time of seizure in 12 cases (12/55, 22%). CQ5. According to the prognostic IDH/TERT classification of diffuse glioma cases (n = 94), overall survival (OS) times of GRE(+) cases tended to be longer than that of GRE(-) ones, especially in IDH wildtype/TERT mutated group (22.7 months vs. 8.3 months, p = 0.0397). Conclusion. GRE is likely associated with specific clinical and molecular features. Seizure in glioma patients can occur in specific situation regardless of the use of AEDs. Possible better prognosis of GRE(+) cases requires further investigation.
Assessing research excellence: Evaluating the Research Excellence Framework
Authors: Pinar Mehmet , Horne Timothy J 
Published: December 2021

AbstractPerformance-based research funding systems have been extensively used around the globe to allocate funds across higher education institutes (HEIs), which led to an increased amount of literature examining their use. The UK’s Research Excellence Framework (REF) uses a peer-review process to evaluate the research environment, research outputs and non-academic impact of research produced by HEIs to produce a more accountable distribution of public funds. However, carrying out such a research evaluation is costly. Given the cost and that it is suggested that the evaluation of each component is subject to bias and has received other criticisms, this article uses correlation and principal component analysis to evaluate REF’s usefulness as a composite evaluation index. As the three elements of the evaluation—environment, impact and output—are highly and positively correlated, the effect of the removal of an element from the evaluation leads to relatively small shifts in the allocation of funds and in the rankings of HEIs. As a result, future evaluations may consider the removal of some elements of the REF or reconsider a new way of evaluating different elements to capture organizational achievement rather than individual achievements.
Salivary gland ultrasonography in patients with connective tissue diseases: a multi-centre observational study
Authors: Lesturgie-Talarek Manon , Goossens Julia , Berkani Sabryne , Forien Marine , Juge Pierre-Antoine , Ebstein Esther , Palazzo Elisabeth , Borie Raphael , Crestani Bruno , Dieudé Philippe , Ottaviani Sébastien 
Published: December 2021

Abstract

Objective
US of salivary glands (SGUS) is a non-invasive tool that allows for diagnosing primary SS (pSS) or secondary SS (sSS). However, little is known about the prevalence of US findings of SS in other CTDs. The aim of this multi-centre observational study was to evaluate, in CTD patients with or without SS, the prevalence of abnormal SGUS findings and the possible association of the findings with clinical or biological phenotypes.

Methods
B-Mode SGUS was performed by one operator blinded to clinical data. Each SG was semi-quantitatively rated on a scale from 0 to 4 according to the Jousse-Joulin score; a score ≥2 was considered pathological.

Results
Data for 194 patients were analysed (pSS, n = 30; sSS, n = 39; other CTDs, n = 77; controls, n = 48). SGUS findings were abnormal in 80%, 67%, 25% and 2% of patients, respectively. Independent of the underlying disease, age and sex, abnormal SGUS findings were significantly associated with presence of anti-SSA antibodies (P &lt; 0.001), pSS (P &lt; 0.001) and sSS (P &lt; 0.01). Among SS patients, abnormal SGUS findings were associated with the presence of hypergammaglobulinemia, anti-SSA antibodies, objective eye dryness and increased anti-nuclear antibody level, with no difference in EULAR SS Disease Activity Index.

Conclusion
Abnormal SGUS findings were associated with anti-SSA antibody positivity independent of the underlying disease. In SS patients, abnormal findings were associated with immunologic features and mouth involvement. Among CTD patients, SGUS changes may be associated with a particular immune profile.
Genomic Analyses of Rose Crown Gall-Associated Bacteria Revealed Two New Agrobacterium Species: Agrobacterium burrii sp. nov. and Agrobacterium shirazense sp. nov.
Authors: Mafakheri Hamzeh , Taghavi S. Mohsen , Khezerpour Kamran , Kuzmanović Nemanja , Osdaghi Ebrahim 
Published: December 2021

Agrobacterium tumefaciens species complex contains a set of diverse bacterial strains, most of which are well known for their pathogenicity on agricultural plants causing crown gall diseases. Members of A. tumefaciens species complex are classified into several taxonomically distinct lineages called “genomospecies” (13 genomospecies until early 2021). Recently, two genomospecies, G19 (strains RnrT, Rew, and Rnw) and G20 (strains OT33T and R13) infecting Rosa sp. plants in Iran, were described based on biochemical and molecular-phylogenetic data. Whole genome sequence-based core-genome phylogeny followed by average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) calculations performed in this study suggested that genomospecies G19 and G20 could be described as two novel and standalone species. In the phylogenetic tree, these two new genomospecies were clustered separately from other genomospecies/species of A. tumefaciens species complex. Moreover, both ANI and dDDH indices between the G19/G20 strains and other Rhizobiaceae members are clearly below the accepted thresholds for prokaryotic species description. Hence, Agrobacterium burrii sp. nov. is proposed to encompass the G19 strains, with RnrT = CFBP 8705T = DSM 112541T as type strain. Agrobacterium shirazense sp. nov. is also proposed to include G20 strains, with OT33T = CFBP 8901T = DSM 112540T as type strain. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Hopelessness in New York State Physicians During the First Wave of the COVID-19 Outbreak
Authors: Johnson Alexander A. , Wallace Brendan K. , Xu Qianhui , Chihuri Stanford , Hoven Christina W. , Susser Ezra S. , DiMaggio Charles , Abramson David , Andrews Howard F. , Lang Barbara H. , Ryan Megan , Li Guohua 
Published: December 2021

Background:
In the United States, New York State’s health care system experienced unprecedented stress as an early epicenter of the coronavirus disease 2019 (COVID-19) pandemic. This study aims to assess the level of hopelessness in New York State physicians working on the frontlines during the first wave of the COVID-19 outbreak.

Methods:
A confidential online survey sent to New York State health care workers by the state health commissioner’s office was used to gather demographic and hopelessness data as captured by a brief Hopelessness Scale. Adjusted linear regression models were used to assess the associations of physician age, sex, and number of triage decisions made, with level of hopelessness.

Results:
In total, 1330 physicians were included, of whom 684 were male (51.4%). Their average age was 52.4 years (SD=12.7), with the majority of respondents aged 50 years and older (55.2%). Almost half of the physician respondents (46.3%) worked directly with COVID-19 patients, and 163 (12.3%) were involved in COVID-19-related triage decisions. On adjusted analysis, physicians aged 40 to 49 years had significantly higher levels of hopelessness compared with those aged 50 years or more (μ=0.441, SD=0.152, P=0.004). Those involved in 1 to 5 COVID-19-related triage decisions had a significantly lower mean hopelessness score (μ=−0.572, SD=0.208, P=0.006) compared with physicians involved in none of these decisions.

Conclusion:
Self-reported hopelessness was significantly higher among physicians aged 40 to 49 years and those who had not yet been involved in a life or death triage decision. Further work is needed to identify strategies to support physicians at high risk for adverse mental health outcomes during public health emergencies such as the COVID-19 pandemic.