bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aligning Human and Computational Evaluations of Functional Design Similarity
Authors: Nandy Ananya , Goucher-Lambert Kosa 
Published: November 2021

Abstract
Function drives many early design considerations in product development. Therefore, finding functionally similar examples is important when searching for sources of inspiration or evaluating designs against existing technology. However, it is difficult to capture what people consider to be functionally similar and therefore, if measures that compare function directly from the products themselves are meaningful. In this work, we compare human evaluations of similarity to computationally determined values, shedding light on how quantitative measures align with human perceptions of functional similarity. Human perception of functional similarity is considered at two levels of abstraction: (1) the high-level purpose of a product, and (2) a detailed view of how the product works. Human evaluations of similarity are quantified by crowdsourcing 1360 triplet ratings at each functional abstraction, and then compared to similarity that is computed between functional models. We demonstrate how different levels of abstraction and the fuzzy line between what is considered “similar” and “similar enough” may impact how these similarity measures are utilized, finding that different measures better align with human evaluations along each dimension. The results inform how product similarity can be leveraged by designers. Therefore, applications lie in creativity support tools, such as those used for design-by-analogy, or future computational methods in design that incorporate product function in addition to form.
Lessons Learned About Product Redesign for Evolvability Using Reflective Entries
Authors: Jacobson Lindsey , Ferguson Scott 
Published: November 2021

Abstract
The operating conditions for, and requirements of, a product may change in unexpected ways while it is in service. Products incapable of meetings these new requirements lose value. This reduction in value diminishes the user experience or product replacement occurs. Previous studies in the literature have investigated principles of design flexibility, modularity, excess, and margins as they apply to the redesign of an existing product as a means of keeping it in service. Design tools, such as Design Structure Matrices (DSMs) and change propagation techniques, give the engineer insight into managing the redesign process. However, there is limited data about perceptions of the redesign process and the challenges that arise. This paper explores the redesign of a single system with particular focus on the design objective, the utility offered by existing design tools, and the perception of excess. A pod-based coffee maker is redesigned as the pod carrying the coffee grounds has been discontinued. Three conceptual redesign solutions are generated by the co-author who also wrote reflections discussing her perspectives and experiences throughout the redesign process. The reflections from the co-author highlight questions about how designers identify valuable system attributes when redesigning a system (already in service) to meet new requirements. The co-author’s experience also provides evidence that (1) there is a relationship between design tool and redesign strategy, (2) that it was easier to conceptualize redesign work with excess around functional requirements than spatial interfaces, and (3) that the perceived amount of excess in a system influences the chosen design strategy.
Impact of maternal obesity on neonatal heart rate and cardiac size
Authors: Groves Alan M , Price Anthony N , Russell-Webster Tamarind , Jhaveri Simone , Yang Yang , Battersby Ellie E , Shahid Shiffa , Costa Vieira Matais , Hughes Emer , Miller Faith , Briley Annette L , Singh Claire , Seed Paul T , Chowienczyk Phillip J , Stern Kenan W D , Cohen Jennifer , Pasupathy Dharmintra , Edwards A David , Poston Lucilla , Taylor Paul D 
Published: November 2021

BackgroundMaternal obesity may increase offspring risk of cardiovascular disease. We assessed the impact of maternal obesity on cardiac structure and function in newborns as a marker of fetal cardiac growth.MethodsNeonates born to mothers of healthy weight (body mass index (BMI) 20–25 kg/m2, n=56) and to mothers who were obese (BMI ≥30 kg/m2, n=31) underwent 25-minute continuous ECG recording and non-sedated, free-breathing cardiac MRI within 72 hours of birth.ResultsMean (SD) heart rate during sleep was higher in infants born to mothers who were versus were not obese (123 (12.6) vs 114 (9.8) beats/min, p=0.002). Heart rate variability during sleep was lower in infants born to mothers who were versus were not obese (SD of normal-to-normal R-R interval 34.6 (16.8) vs 43.9 (16.5) ms, p=0.05). Similar heart rate changes were seen during wakefulness. Left ventricular end-diastolic volume (2.35 (0.14) vs 2.54 (0.29) mL/kg, p=0.03) and stroke volume (1.50 (0.09) vs 1.60 (0.14), p=0.04) were decreased in infants born to mothers who were versus were not obese. There were no differences in left ventricular end-systolic volume, ejection fraction, output or myocardial mass between the groups.ConclusionMaternal obesity was associated with increased heart rate, decreased heart rate variability and decreased left ventricular volumes in newborns. If persistent, these changes may provide a causal mechanism for the increased cardiovascular risk in adult offspring of mothers with obesity. In turn, modifying antenatal and perinatal maternal health may have the potential to optimise long-term cardiovascular health in offspring.
PandAcuity in paediatrics: a novel clinical measure of visual function based on the panda illusion
Authors: Kelbsch Carina , Spieth Bettina , Zrenner Eberhart , Besch Dorothea , Straßer Torsten 
Published: November 2021

Background/aimsTo evaluate the PandAcuity test for visual function testing in a paediatric cohort and to examine its agreement with conventional visual acuity (VA) testing.MethodsPandAcuity scores were determined in 152 children (77 males) aged between 3 and 15 years after VA testing (LEATM-test, E-chart, Landolt-C-rings or numbers). The PandAcuity test consisted of illusions made up from silhouettes of animals ‘hidden’ within zig-zag-patterns of decreasing spatial frequencies. Correlation analyses between PandAcuity score and VA were performed.Results150 children completed the test in at least one eye, 148 in both eyes. The PandAcuity test demonstrated good test–retest reliability (intraclass correlation coefficient=0.89) between two runs. VA and PandAcuity score showed a medium to large correlation (Spearman’s ρ=0.52, p<0.0001). 93% of the children’s visual impairment was classified in the same range by both test types. Receiver operating characteristic analysis of predicted visual impairment showed an excellent agreement with the classification based on VA testing (AUC=0.84).ConclusionThe PandAcuity test is rapid, simple and well accepted, rendering it a suitable supplement for the clinical assessment of VA in children. Because of its counterintuitive application (a higher number of correctly identified images means worse VA), it can be used to cross-validate conventional acuity tests to assure children’s compliance.
Barriers to decolonising educational partnerships in global health
Authors: Kulesa John , Brantuo Nana Afua 
Published: November 2021

Global health partnerships between high-income countries and low/middle-income countries can mirror colonial relationships. The growing call to advance global health equity therefore involves decolonising global health partnerships and outreach. Through decolonisation, local and international global health partners recognise non-western forms of knowledge and authority, acknowledge discrimination and disrupt colonial structures and legacies that influence access to healthcare.Despite these well-described aims, the ideal implementation process for decolonising global health remains ill-defined. This ambiguity exists, in part, because partners face barriers to adopting a decolonised perspective. Such barriers include overemphasis on intercountry relationships, implicit hierarchies perpetuated by educational interventions and ethical dilemmas in global health work.In this article, we explore the historical entanglement of education, health and colonialism. We then use this history as context to identify barriers that arise when decolonising contemporary educational global health partnerships. Finally, we offer global health partners strategies to address these challenges.
Self-thermophoresis of laser-heated spherical Janus particles
Authors: Avital E. J. , Miloh T. 
Published: November 2021

Abstract
An analytic framework is presented for calculating the self-induced thermophoretic velocity of a laser-heated Janus metamaterial micro-particle, consisting of two conducting hemispheres of different thermal and electric conductivities. The spherical Janus is embedded in a quiescent fluid of infinite expanse and is exposed to a continuous light irradiation by a defocused laser beam. The analysis is carried under the electrostatic (Rayleigh) approximation (radius small compared to wavelength). The linear scheme for evaluating the temperature field in the three phases is based on employing a Fourier–Legendre approach, which renders rather simple semi-analytic expressions in terms of the relevant physical parameters of the titled symmetry-breaking problem. In addition to an explicit solution for the self-thermophoretic mobility of the heated Janus, we also provide analytic expressions for the slip-induced Joule heating streamlines and vorticity field in the surrounding fluid, for a non-uniform (surface dependent) Soret coefficient. For a ‘symmetric’ (homogeneous) spherical particle, the surface temperature gradient vanishes and thus there is no self-induced thermophoretic velocity field. The ‘inner’ temperature field in this case reduces to the well-known solution for a laser-heated spherical conducting colloid. In the case of a constant Soret phoretic mobility, the analysis is compared against numerical simulations, based on a tailored collocation method for some selected values of the physical parameters. Also presented are some typical temperature field contours and heat flux vectors prevailing in the two-phase Janus as well as light-induced velocity and vorticity fields in the ambient solute and a new practical estimate for the self-propelling velocity.

Graphic abstract
Model Transformation Development Using Automated Requirements Analysis, Metamodel Matching, and Transformation by Example
Authors: Lano K. , Kolahdouz-Rahimi S. , Fang S. 
Published: November 2021

In this article, we address how the production of model transformations (MT) can be accelerated by automation of transformation synthesis from requirements, examples, and metamodels. We introduce a synthesis process based on metamodel matching, correspondence patterns between metamodels, and completeness and consistency analysis of matches. We describe how the limitations of metamodel matching can be addressed by combining matching with automated requirements analysis and model transformation by example (MTBE) techniques.
We show that in practical examples a large percentage of required transformation functionality can usually be constructed automatically, thus potentially reducing development effort. We also evaluate the efficiency of synthesised transformations.

Our novel contributions are:

The concept of correspondence patterns between metamodels of a transformation.

Requirements analysis of transformations using natural language processing (NLP) and machine learning (ML).

Symbolic MTBE using “predictive specification” to infer transformations from examples.

Transformation generation in multiple MT languages and in Java, from an abstract intermediate language.
Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
Authors: López Mirian , Padilla María Luz , García Blas , Orozco Javier , Rodilla Ana María 
Published: November 2021

Background. Acute postoperative pain (APP) has a high incidence in breast surgery, and opioids are the most commonly used drugs for its management; however, they are not free from systemic side effects, which may increase comorbidity. In the past few years, opioid-free anaesthesia has been favoured with promising results. Methods. We conducted a descriptive study including 71 patients who underwent breast cancer surgery. The opioid group (n = 41) received fentanyl for induction, remifentanil for maintenance, and rescue morphine before waking up, whereas the ketamine group (n = 30) received a ketamine bolus for induction followed by continuous ketamine infusion during surgery. Later, the presence and intensity of pain were registered, using the Numeric Rating Scale (NRS 1–10) for pain, at different times in the recovery room, at 24 hours and at 3 months. Results. Administration of ketamine is more effective than opioid use for APP prevention in breast cancer surgery because the ketamine group presented with less pain than the opioid group (

p

< 0.05) at all measured times. When there was pain, patients in the ketamine group gave a lower score to its intensity (

p

< 0.05). Conclusions. Ketamine could reduce the incidence of APP in breast cancer surgery, compared to opioids.
Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)
Authors: Mato Anthony R. , Davids Matthew S. , Sharman Jeff , Roeker Lindsey E. , Kay Neil , Kater Arnon P. , Rogers Kerry , Thompson Meghan C. , Rhodes Joanna , Goy Andre , Skarbnik Alan , Schuster Stephen J. , Tam Constantine S. , Eyre Toby A. , O'Brien Susan , Nabhan Chadi , Lamanna Nicole , Sun Clare , Shadman Mazyar , Pagel John M. , Ujjani Chaitra , Brander Danielle , Coombs Catherine C. , Jain Nitin , Cheah Chan Y. , Brown Jennifer R. , Seymour John F. , Woyach Jennifer A. 
Published: November 2021

Abstract
The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.
Association of Neutrophil-to-Lymphocyte Ratio with Efficacy of First-Line Avelumab plus Axitinib vs. Sunitinib in Patients with Advanced Renal Cell Carcinoma Enrolled in the Phase 3 JAVELIN Renal 101 Trial
Authors: Bilen Mehmet A. , Rini Brian I. , Voss Martin H. , Larkin James , Haanen John B.A.G. , Albiges Laurence , Pagliaro Lance C. , Voog Eric G. , Lam Elaine T. , Kislov Nikolay , McGregor Bradley A. , Lalani Aly-Khan A. , Huang Bo , di Pietro Alessandra , Krulewicz Stan , Robbins Paul B. , Choueiri Toni K. 
Published: November 2021

Abstract

Purpose:
To evaluate the association between neutrophil-to-lymphocyte ratio (NLR) and efficacy of avelumab plus axitinib or sunitinib.

Experimental Design:
Adult patients with untreated advanced renal cell carcinoma (RCC) with a clear-cell component, ≥1 measurable lesions, Eastern Cooperative Oncology Group performance status of 0 or 1, fresh or archival tumor specimen, and adequate renal, cardiac, and hepatic function were included. Retrospective analyses of the association between baseline NLR and progression-free survival (PFS) and overall survival (OS) in the avelumab plus axitinib or sunitinib arms were performed using the first interim analysis of the phase 3 JAVELIN Renal 101 trial (NCT02684006). Multivariate Cox regression analyses of PFS and OS were conducted. Translational data were assessed to elucidate the underlying biology associated with differences in NLR.

Results:
Patients with below-median NLR had longer observed PFS with avelumab plus axitinib [stratified HR, 0.85; 95% confidence interval (CI), 0.634–1.153] or sunitinib (HR, 0.56; 95% CI, 0.415–0.745). In the avelumab plus axitinib or sunitinib arms, respectively, median PFS was 13.8 and 11.2 months in patients with below-median NLR, and 13.3 and 5.6 months in patients with median-or-higher NLR. Below-median NLR was also associated with longer observed OS in the avelumab plus axitinib (HR, 0.51; 95% CI, 0.300–0.871) and sunitinib arms (HR, 0.30; 95% CI, 0.174–0.511). Tumor analyses showed an association between NLR and key biological characteristics, suggesting a role of NLR in underlying mechanisms influencing clinical outcome.

Conclusions:
Current data support NLR as a prognostic biomarker in patients with advanced RCC receiving avelumab plus axitinib or sunitinib.
Characterization of Novel α-Mangostin and Paeonol Derivatives With Cancer-Selective Cytotoxicity
Authors: Nunna Suneetha , Huang Ying-Pei , Rasa Mahdi , Krepelova Anna , Annunziata Francesco , Adam Lisa , Käppel Sandra , Hsu Ming-Hua , Neri Francesco 
Published: November 2021

Abstract
α-Mangostin (aMan) and Paeonol (Pae) have shown anticancer and anti-inflammatory properties. However, these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as potential novel chemicals that increase cancer cell cytotoxicity over nontransformed human cells. We found that two derivative compounds, named α-Mangostin-1 (aMan1) and Paeonol-1 (Pae1) more efficiently and more specifically induced cytotoxicity in HCT116, HT29, and SW48 colorectal cancer cell lines than the parental compounds. Both aMan1 and Pae1 arrested HCT116 cells in the G1 phase and HT29 and SW48 cells in the G2–M phase of the cell cycle. Both aMan1 and Pae1 induced apoptosis in human colorectal cancer cells, through a caspase-dependent mechanism. aMan1 and Pae1 induced selective transcriptional responses in colorectal cancer cells involving genes related to metabolic stress and DNA damage response signaling pathways. Finally, experiments on primary colon organoids showed that both derivatives were able to kill cancer-derived organoids without affecting the viability of organoids derived from healthy tissue, where the parental compounds and the currently used chemotherapeutic drug irinotecan failed. In conclusion, our findings expand the knowledge of natural compound derivatives as anticancer agents and open new avenues of research in the derivation of lead compounds aimed at developing novel chemotherapeutic drugs for colorectal cancer treatment that selectively target cancer, but not healthy cells.
Targeting the mTOR Pathway in Hurthle Cell Carcinoma Results in Potent Antitumor Activity
Authors: Dong Yiyu , Gong Yongxing , Kuo Fengshen , Makarov Vladimir , Reznik Ed , Nanjangud Gouri J. , Aras Omer , Zhao Huiyong , Qu Rui , Fagin James A. , Sherman Eric J. , Xu Bin , Ghossein Ronald , Chan Timothy A. , Ganly Ian 
Published: November 2021

Abstract
Hurthle cell carcinomas (HCCs) are refractory to radioactive iodine and unresponsive to chemotherapeutic agents, with a fatality rate that is the highest among all types of thyroid cancer after anaplastic thyroid cancer. Our previous study on the genomic landscape of HCCs identified a high incidence of disruptions of mTOR pathway effectors. Here, we report a detailed analysis of mTOR signaling in cell line and patient-derived xenograft mouse models of HCCs. We show that mTOR signaling is upregulated and that targeting mTOR signaling using mTOR inhibitors suppresses tumor growth in primary tumors and distant metastasis. Mechanistically, ablation of mTOR signaling impaired the expression of p-S6 and cyclin A2, resulting in the decrease of the S phase and blocking of cancer cell proliferation. Strikingly, mTOR inhibitor treatment significantly reduced lung metastatic lesions, with the decreased expression of Snail in xenograft tumors. Our data demonstrate that mTOR pathway blockade represents a novel treatment strategy for HCC.
Pentecostal Theology, Identity Politics, and Racialized Xenophobia: Claiming A New Social Order
Authors: Hankela Elina 
Published: November 2021

Abstract
Applying the methodological lens of ethnographic theology, the article argues that grounded Pentecostal theologies participate in reimagining a new social order, particularly in relation to racialized xenophobia. This argument is made in the specific context of two Pentecostal churches in Johannesburg, South Africa, both led and frequented by people who have come to Johannesburg from other parts of the African continent. The argument is outlined by unpacking three theological themes prominent in the collected ethnographic data: positive confession, Word-centred ecclesiology, and Christlike lifestyle. Taken together, these themes highlight a social conscience that other societal actors would do well to take seriously when considering combatting xenophobia. Overall, the article challenges the scholarly emphasis on Pentecostal theologies as uninterested in life-affirming structural change, building on Nimi Wariboko’s formulation of blackness, chosenness, and Nigerian Pentecostalism ‘that reads against the existing social order’ within the particular context of xenophobia in urban South Africa.
Human Rights, Islam, and Debates around CEDAW
Authors: Fazaeli Roja , Hanisek Joel 
Published: November 2021

Abstract
The article explores the tensions between FORB claims and the advancement of women’s rights in Muslim majority state contexts. Forms of Muslim majority state reservations to CEDAW are analysed in critical and comparative fashion. Iran’s historical engagement with CEDAW is studied for insight into how a purported theoretical conflict between CEDAW and FORB may be better understood in terms of the domestic and international politics of gender and power.
Kittsteiner’s History Out of Joint
Authors: Wimmer Mario 
Published: November 2021

Abstract
In this article, I portray both the “thinking historian” Heinz-Dieter Kittsteiner and his philosophical analysis of the unavailability of the historical process. In his book Out of Control (2004), Kittsteiner builds on Immanuel Kant’s concept of the historical sign to demonstrate how history is out of joint due to the contingent character of the historical process. This understanding demands a new theory of historical time and of historiographical practice, which I reconstruct through a close reading of a chapter of Kittsteiner’s book.