bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of head-neck hemangioma patient at single center-hospital, Indonesia
Authors: Baihaqi Rizki , Wibowo Marjono Dwi 
Published: January 2025

Link of Video Abstract: https://youtu.be/9f1p4siy108

Background: Hemangioma is a benign vascular tumor that most often appears in the head and neck area. The head and neck have five main distribution locations: labial, lingual, buccal, nasal, and cervical. However, data on the profile and distribution of the location of head and neck hemangiomas is still very minimal. This study aims to determine the profile of head and neck hemangioma patients in a single-center hospital in Indonesia.
Method: This research is a descriptive observational study conducted at a single-center hospital, Dr. Soetomo, General Hospital, Surabaya, Indonesia, from January 2018 to August 2023. The subjects of this study used medical record data, with the variables analyzed being the patient's age, sex, location, size, management, and response to sclerotherapy treatment.
Results: The head and neck hemangioma patients majority were female, 65.4%, and in the buccal region (50%), with the largest age group being children (5-11 years). The average lesion size was 37.06 m2, with the age group below five years having the largest average lesion.
Conclusion: The profile and distribution of locations vary greatly, but the lesion size is closely related to the pathophysiology of hemangioma, which is related to the age group.
The relationship between residual cancer burden and disease-free survival in locally advanced post-neoadjuvant chemotherapy breast cancer at Dr. Soetomo General Hospital, Surabaya
Authors: Utomo Heningtyas Suci , Suprabawati Desak Gede Agung , Ali Iskandar 
Published: January 2025

Link of Video Abstract: https://youtu.be/c8EpIRNHkG0

Background: Locally advanced breast cancer is characterized by advanced-stage breast tumors without distant metastasis. Neoadjuvant chemotherapy is employed in locally advanced breast cancer to reduce tumor burden and enable breast surgery. Neoadjuvant chemotherapy also offers an opportunity to evaluate breast cancer patient responses to therapeutic modalities. The Residual Cancer Burden (RCB) index combines pathological findings from the primary tumor base and regional lymph nodes to calculate a continuous index that accurately predicts recurrence rates and survival in breast cancer patients. This study aimed to assess recurrence-free survival to estimate the prognostic level of breast cancer after neoadjuvant chemotherapy based on the RCB Index.
Methods: This study is an observational analytical retrospective cohort study involving patients with locally advanced breast cancer who received neoadjuvant chemotherapy-based treatment. Clinical data and RCB scores were obtained retrospectively. Local and distant recurrence were followed for two years.
Results: A total of 30 research subjects were included in this study. The RCB score was ≤1 in 10% of cases and >1 in 90% of cases. The recurrence rate for local and distant recurrence within 24 months was 50%, with a recurrence rate of 0% for RCB ≤1 and 37% for RCB >1. Chi-square analysis indicated no significant difference in the incidence of recurrence within 24 months between RCB ≤1 and RCB >1 with a p-value of (0.224).
Conclusion: There is no relationship between RCB and disease-free survival in locally advanced breast cancer following neoadjuvant chemotherapy.
The anti-inflammatory potential of epigallocatechin gallate (EGCG) on tumor necrosis factor alpha and interleukin–10 expression in pseudomonas keratitis model (in vivo study on Rattus norvegicus rats model)
Authors: Fathimah Fariztah Sukainah Nur , Zuhria Ismi , Lutfi Delfitri , Urolita Tarosa Yodia , Karima Annisa , Kurniasari Nila , Purwanto Djoko Agus 
Published: January 2025

Background: Pseudomonas aeruginosa infection is the primary cause of keratitis, leading to gradual corneal deterioration and resulting in scarring, thinning, and corneal perforation. Antibiotic treatment alone may prove ineffectual in certain instances, as the inflammatory process may remain despite the elimination of bacteria. Due to its antibacterial, anti-inflammatory, and antioxidant properties, Epigallocatechin gallate (EGCG) has the potential to be used as an adjuvant therapy for Pseudomonas keratitis. The objective of this study is to analyze the expression of TNF-α and IL-10 in a P. aeruginosa-induced keratitis model following the administration of moxifloxacin and EGCG eye drops.
Methods: Rattus norvegicus with keratitis induced by clinical isolate P. aeruginosa were randomly allocated to one of three treatment groups: the negative control group given NaCl 0.93% and benzalkonium chloride 0.01%; the group given moxifloxacin eye drops; and the group given moxifloxacin eye drops and EGCG 50 μg/mL on the third to fifth day after keratitis induction. Immunohistochemical staining of corneal tissue was utilized to analyze the levels of TNF-α and IL-10 expression.
Results: On the fifth day of subsequent keratitis induction, a statistically significant difference in TNF-α expression was observed across the groups (p=0.015). It was found between the moxifloxacin and EGCG 50 g/mL groups and the negative control group (p=0.008). IL-10 expression showed no significant difference across the groups (p=0.108).
Conclusion: TNF-α expression was significantly different among the three groups, whereas IL-10 expression was not significantly different.
Comparative analysis of pathoscan hrHPV qPCR kits with four- and five-channel qPCR methods for the identification of high-risk human papillomaviruses
Authors: Wulandari Dewi , Umboh Rocky Dousje , Mardian Yan 
Published: January 2025

Introduction: In Indonesia, cervical cancer remains a serious health concern. WHO recommends high-risk human papillomavirus (hrHPV) DNA testing as the primary tool of screening instead of cytology and visual inspection with acetic acid. The Indonesian government has been encouraging the usage of locally manufactured medical devices including laboratory supplies and reagent kits. PathoScan hrHPV qPCR kit (PT Riset Nusantara Genetika, Nusantics Group, Indonesia) is one of the locally manufactured kits and was originally designed for 5-channel qPCR for hrHPV DNA detection. However, most clinical laboratories in Indonesia employ 4-channel qPCR instruments. Therefore, the PathoScan hrHPV Lite qPCR kit was developed as an alternative, needing only a 4-channel qPCR instrument. This study aims to assess its diagnostic performance in comparison to the PathoScan hrHPV qPCR kit
Methods: This is a cross-sectional study evaluating the PathoScan hrHPV Lite qPCR kit (4-channel) on 96 cervical swab samples that were previously tested with the PathoScan hrHPV qPCR kit (5-channel) to determine its diagnostic performance using the following metrics: sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Bland-Altman analysis was utilized to evaluate the agreement between Ct values obtained between the two methods.
Result: The diagnostic performance of the kit was assessed on 96 cervical swab samples, which comprised 47 positive and 49 negative samples as determined by the PathoScan kit. The PathoScan hrHPV Lite qPCR kit's sensitivity in the present study was 100% (95% CI 92.29-100%) and the specificity observed was 100% (95% CI 92.75-100%). The Bland-Altman plot indicated good agreement with <5% results falling beyond the acceptable upper and lower limits.
Conclusion: PathoScan hrHPV Lite qPCR kit displayed excellent diagnosis accuracy and good agreement, suggesting it can be used for primary cervical cancer screening.
Ni-doped Al2O3-based materials for the photocatalytic degradation of phenol
Authors: Gómez-Cholula Deysi , Crespo Juan Edgar Carrera , Morales Francisco Javier Tzompantzi , Cipagauta-Díaz Sandra 
Published: January 2025

AbstractThe photocatalytic degradation of phenol over Ni-doped Al2O3 was investigated. Materials varying Ni concentrations were synthesized and characterized by XRD, FTIR, UV–Vis–DRS, and XPS. The results showed that Ni doping significantly enhanced photocatalytic activity, attributable to increased UV light absorption and efficient charge carrier separation. The optimal Ni concentration was found to be 1.5 wt%, achieving a 70% phenol degradation in 4 h. These findings suggest that Ni-doped Al2O3 holds great promise for wastewater remediation.
Graphical abstract
Supposed Corpses and Correspondence
Authors: Sugarman Elise 
Published: January 2025

The correspondence requirement is a fundamental doctrinal principle in Anglo-American criminal law. It maintains that, in general, a particular relation between mens rea and actus reus is necessary for liability. Yet the nature of this relation is contested. Contemporaneity Theorists maintain that correspondence requires temporal overlap between mens rea and actus reus, while Causal Theorists maintain that correspondence is a non-deviant causal connection.
In this paper, I argue that neither Contemporaneity Theory nor Causal Theory is able to account for the intuition that a special class of defendants—defendants in so-called supposed corpse cases—are liable for murder. Supposed corpse defendandts attempt to kill at t1, erroneously suppose they have done so, and then act again to cause death at t2. I go on to provide a novel positive proposal of correspondence in such cases. I argue that supposed corpse defendants are liable for murder because their killing is explained by ignorance that is in turn explained by an apparently successful execution of their intention to kill. The result serves as demonstration that the relation between intention and action grounding culpability is not the same as the relation grounding an action's status as intentional.
Editorial
Authors: Ruschel Regina Coeli , Bernardini Sidney Piochi , Rossi Michele Marta , Silva Arthur Santos , Oliveira Maria Fernanda de , Melo Reymard Sávio Sampaio de , Melachos Felipe Corres , Silva Vanessa Gomes da 
Published: January 2025

O 15º volume da revista eletrônica PARC: Pesquisa em Arquitetura e Construção reúne artigos distribuídos em três seções: Artigos, Artigos de Revisão e Dossiê. As 25 publicações abordam temas como adequação ambiental, construção civil, tecnologia de arquitetura e urbanismo, além de planejamentos e projetos da edificação, do equipamento e do espaço urbano. A seção Dossiê, assim como alguns artigos de revisão, desenvolve a temática de Modelagem da informação da Construção e interface com a Construção 4.0. Os artigos publicados refletem avanços tecnológicos e respondem a demandas contemporâneas, destacando a relevância cultural, social e econômica das pesquisas em Arquitetura e Construção. Desejamos a todos uma leitura enriquecedora.
Quantification of Rock’s Wettability Index Using Dielectric Measurements
Authors: Oshaish Ali , El-Husseiny Ammar , Mahmoud Mohamed , Al-Ofi Salah , Alarifi Sulaiman A. , Attia Hussein , Al-Yaseri Ahmed , Hassan Amjed 
Published: January 2025

Summary
Wettability is a crucial parameter that governs several petrophysical attributes of oil- and gas-bearing rocks. However, the traditional methods to measure the wettability index are restricted to laboratory techniques, which makes that measurement expensive and time-consuming. Due to its sensitivity to fluid-solid interaction and the large contrast between the dielectric constant of oil and water, earlier studies investigated the use of dielectric measurements for wettability evaluation. Nevertheless, these studies mainly focused on the qualitative assessment of the wettability using the dielectric measurements and did not yield a practical and easy-to-implement dielectric-based wettability index correlation. Therefore, the objective of this study is to explore the response of the dielectric dispersion to wettability changes at two water saturation endpoints, full water saturation (Sw=1) and irreducible water saturation (Swirr), and to develop a correlation for obtaining the wettability index from dielectric measurements. A pair (master and sister) of Berea sandstone (BS) and Fontainebleau (FB) sandstone and Indiana limestone (IL) samples were used in the study. The wettability of the sister samples was altered (to make them less water-wet) without impacting porosity before measuring their wettability index. The widely recognized US Bureau of Mines (USBM) wettability index (WIUSBM) served as the benchmark for evaluating the newly developed dielectric wettability index (WIdielectric). Among all measured parameters, imaginary permittivity showed the most consistent and conclusive results, displaying (at frequencies below 200 MHz) a significant drop due to altering the wettability toward more oil-wet. This drop can be attributed to reduced electrical interactions between water and the grain surface due to wettability alteration. A strong linear relationship was also observed between the wettability index of each sample and the drop in its imaginary permittivity as saturation was changed from Sw=1 to Swirr. Therefore, a WIdielectric correlation was developed by incorporating the imaginary permittivity measured at both Sw=1 and Swirr. The developed correlation was able to predict the WIUSBM of the tested samples with R2 of 0.97 and a root mean square error of 0.066. Overall, this study offers an in-depth analysis of the dielectric response to various wettability conditions across different saturation levels, which has facilitated the formulation of an equation for determining the wettability index through dielectric measurements. The findings of this research lay the groundwork for broadening the application of dielectric measurements to additional petrophysical analyses and for more accurate characterization of the fluid-rock and fluid-fluid interactions.
Level of knowledge on preconception care and associated factors among healthcare providers working in public health institutions in Adama town, Oromia, Ethiopia
Authors: Feyissa Gemechu Dereje , Girma Gemechis 
Published: January 2025

Abstract

Background: Preconception care is the provision of biomedical, behavioral, and social health interventions to women and couples before pregnancy occurs. Preconception care is the most recently identified innovative approach among the spectrum of maternal and child health services to address all adverse pregnancy outcomes and to considerably reduce maternal, new-born, infant, and child morbidity and mortality. Therefore, the findings of this study may be used as preliminary information by concerned bodies.
Objective: The study aimed to assess the level of knowledge on preconception care and associated factors among healthcare providers working in public health facilities in Adama town, Oromia, Ethiopia, from February 01 to 28, 2022.
Methods: An institutional-based cross-sectional study was conducted among 429 health care providers selected using a multistage sampling technique. Data was collected by an interviewer-administered questioner, then entered into Epi-Info version 7.2 and exported to SPSS version 22 for analysis. Descriptive statistics was performed to describe the study population. A simple binary logistic regression analysis was performed, and variables with a p-value < 0.25 were selected for multivariable regression analysis. The association between dependent and independent variables was estimated by an adjusted odds ratio along with a 95% confidence interval (CI). P-value < 0.05 was considered to declare statistical significance.
Results: Among the total study participants, 261 (61.3%) (95% CI: 56.8%–66.2%) of healthcare providers had a good level of knowledge of preconception care. Among respondents' characteristics, the odds of having a good level of knowledge on preconception care were significantly associated with: male healthcare providers (AOR: 2.25, 95% CI: 1.28–3.95); bachelor of science degree and above holders (AOR: 2.77, 95% CI: 1.4-5.52); medical doctors (AOR: 5.16, 95% CI: 1.6-16.57); midwives (AOR: 3.75, 95% CI: 1.52-9.3); urban extension workers (AOR: 0.34, 95% CI: 0.13-0.89); internet users (AOR: 2.73, 95% CI: 1.44-5.2) and access to a national preconception care protocol (AOR: 1.92, 95% CI: 1.07-3.44).
Conclusion: More than half of healthcare providers in Adama town public health facilities were knowledgeable about preconception care. Male healthcare providers, BSc degree holders, medical doctors, midwives, urban extension workers, internet users, and access to the national preconception care protocol were found to be significantly associated factors. The Regional Health Bureau and Ministry of Health should prepare comprehensive preconception care guidelines and provide learning opportunities for urban health extension workers, diploma health care providers to upgrade their education level and provide continuous pre-service and in-service training on preconception care for all health care providers.
SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis
Authors: Liu Quan , LUO XIZI , Liu Nan , Sui Liyan , Zhang Siwei , Wang Mengmeng , Tian Tian , Xie Hanxi , Zhu Mucuo , Pan Mingming , Tan Qianqian , Jin Fangyu , Fang Shu , Che Lihe , Xu Wenbo , Zhao Yicheng , Zhao Yinghua , Wang Guoqing 
Published: January 2025

Abstract

COVID-19 associated coagulation abnormalities and thrombosis are life-threatening complications after SARS-CoV-2 infection. However, the underlying mechanisms are unclear. Here, we found that SARS-CoV-2 spike (S) protein induced excessive reactive oxygen species (ROS) production, disrupting mitochondrial dynamics and causing endothelial cells damage, thereby promoting thrombogenesis. Mechanistically, the S protein inhibited the expression of signaling lymphocytic activation molecule family 8 (SLAMF8) to induce an upregulation of NADPH oxidase 2 (NOX2) expression and p66SHC phosphorylation. This activation of NOX2-p66SHC axis resulted in a persistent elevation of ROS and mitochondrial dynamics disorder, ultimately leading to endothelial cells injury. SARS-CoV-2 infection also promoted the transformation of endothelial cells into a prothrombotic phenotype by inhibiting the expression of SLAMF8. Furthermore, the single-cell sequencing analysis revealed a negative correlation between SLAMF8 expression and thrombotic activity of endothelial cells in COVID-19 patients. Notably, the overexpression of SLAMF8 reversed the S protein-mediated increase in blood flow obstruction and platelet aggregation observed in mice with ferric chloride-induced thrombosis. These findings suggest a distinct mechanism of the S protein in the pathogenesis of SARS-CoV-2-associated thrombosis, providing novel perspectives and strategies for the prevention, management and treatment of thrombotic complications in individuals with COVID-19 or long COVID.
Effectiveness of Blood Transfusion Screening Procedures in Preventing Transfusion- Related Infections
Authors: Ogolla Collince Odiwuor , Guya Benard , Maima Apollo O. 
Published: January 2025

Abstract

Background: Blood transfusion is an important life-saving procedure; however, transfusion risk infections (TRI) have remained a major problem of public health especially in resource-poor countries. Blood transfusions may still result in TRIs, even with screening protocols for blood-borne infections, such as HIV, Hepatitis B (HBV), Hepatitis C (HCV), Syphilis, and Malaria.
Objective: The study aimed at evaluating the effectiveness of blood transfusion screening procedures at Kisii Teaching and Referral Hospital (KTRH) in preventing transfusion-related infections.
Methods: A retrospective cohort study carried out analyses on data involving 108 blood transfusions done at KTRH between January 2022 to December 2023. Data were sourced from hospitals transfusion records including demographic data from patients, transfusion details, HIV screening results, Hepatitis B screening results, Hepatitis C screening results, Syphilis screening results, and Malaria screening results. Incidence of post-transfusion infections tracked and effectiveness of screening protocols determined as per sensitivity, specificity, and positive predictive value (PPV). Bivariate analysis was done to assess the risk factors for post-transfusion infections.
Results: The overall incidence of infections following transfusion was recorded at 2.78% with bacterial infections as the most common types. High sensitivity and specificity were associated with HIV, Hepatitis B and Hepatitis C screening; however, Malaria screening was found to be low in some high-risk groups. Risk factors for post-transfusion infections include long duration of storage of blood and the volume transfused. The cost-effectiveness analysis showed that strengthening of screening protocols on Malaria and contamination by bacteria would enhance blood safety in KTRH.
Conclusion: Findings of the study discovered that although the KTRH screening procedures were efficient in identifying the major bloodborne pathogens such as HIV, Hepatitis B, and Hepatitis C, screening gaps existed concerning Malaria and bacterial infections. Improving these procedures of screening would help to further decrease the incidences of transfusion-related infection into a more safe environment for patients. Recommendations on improving the screening protocols as well as addressing the identified risks have been given.
Polarization super-pixel and feature template for feature extraction from Mueller matrix images
Authors: Wan Jiachen , Pei Haojie , Yao Yue , Li Hao , Cui Wei , Huang Tongyu , Jin Xue , Wang Dakai , Liao Ran , Tao Lili , Ma Hui 
Published: January 2025

Abstract

Mueller matrix images contain rich microstructural information, comprehensively encoded in the high-dimensional polarization feature space. While Mueller matrix is sensitive to microstructural changes down to subwavelength scale, how to extract the relevant polarization features remains a primary challenge for its applications. In this article, we propose a new approach to obtain characteristic pathological features from polarization pixels. At pixel-level, we divide the density distribution of the polarization pixels into a collection of elementary subsets of similar polarization features, named polarization super-pixels (PSP). These PSPs approximate the distribution in polarization space while containing no image-textural information, enabling polarization feature representation. By assigning specific weight coefficients to PSPs, we construct polarimetry feature templates (PFTs) that represent the polarization characteristics of specific pathological structure of interest. Using spatial labels from pathologists, we calculate PSP contributions and assign weight coefficients to create PFTs for identifying cancerous structures. Additionally, with region-of-interest (ROI)-level labels distinguishing cancerous and benign areas, we isolate PSPs sensitive to cancer and construct PFTs for ROI-level classification, including differentiation of cancer subtypes. Validation on pathological tissue slides demonstrates the stability and completeness property of the derived PSP and PFT. We showcase its clinical applications, such as propagating spatial labels from a limited number of labeled pixels to larger regions, and detecting malignancy or cancer-subtype differentiation at ROI-level, enhancing diagnostic workflows.