bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymph Node Tumor Burden Correlates With Tumor Budding and Poorly Differentiated Clusters: A New Prognostic Factor in Colorectal Carcinoma?
Authors: Archilla Ivan , Díaz-Mercedes Sherley , Aguirre José Javier , Tarragona Jordi , Machado Isidro , Rodrigo Maria Teresa , Lopez-Prades Sandra , Gorostiaga Iñigo , Landolfi Stefania , Alén Begoña Otero , Balaguer Francesc , Castells Antoni , Camps Jordi , Cuatrecasas Miriam 
Published: February 2021

INTRODUCTION:
Molecular lymph node (LN) staging in early colorectal cancer (CRC) has demonstrated to be more precise than conventional histopathology pN staging. Tumor budding (TB) and poorly differentiated clusters (PDCs) are associated with LN metastases, recurrences, and lower survival in CRC. We evaluated the correlation between the total tumor load (TTL) in LNs from CRC surgical specimens with patient outcome, TB, and PDC.

METHODS:
In this retrospective multicentre study, 5,931 LNs from 342 stage I–III CRC were analyzed by both hematoxylin and eosin and molecular detection of tumor cytokeratin 19 mRNA by one-step nucleic acid amplification. TB and PDC were evaluated by hematoxylin and eosin and cytokeratin 19 immunohistochemistry.

Results:
One-step nucleic acid was positive in 38.3% patients (n = 131). Tumor Budding was low in 45% cases, intermediate in 25%, and high in 30%. Poorly Differentiated Clusters were low-grade G1 in 53%, G2 in 32%, and G3 in 15%. TB and PDC correlated with TTL, high-grade, lymphovascular and perineural invasion, pT, pN and stage (P < 0.001). TB, PDC, and TTL ≥ 6,000 copies/µL were associated with worse overall survival (P = 0.002, P = 0.013, and P = 0.046) and disease-free survival (P < 0.001).

Discussion:
The implementation of more sensitive molecular methods to assess LN status is a promising alternative approach to pN staging, which could be integrated to other factors to help risk stratification and management of patients with early-stage CRC. This study demonstrates the correlation of the amount of LN tumor burden with TB and PDCs. TTL is related to the outcome and could be used as a new prognostic factor in CRC (see Visual Abstract, Supplementary Digital Content 2, http://links.lww.com/CTG/A512).
Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D
Authors: Cibert-Goton Vincent , Lam Ching , Lingaya Melanie , Falcone Yirga , Wood John N. , Bulmer David C. , Spiller Robin 
Published: February 2021

INTRODUCTION:
Despite heterogeneity, an increased prevalence of psychological comorbidity and an altered pronociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome (IBS). Our aim was to study these phenomena by comparing gut-related symptoms, psychological scores, and biopsy samples generated from a detailed diarrhea-predominant IBS patient (IBS-D) cohort before their entry into a previously reported clinical trial.

METHODS:
Data were generated from 42 patients with IBS-D who completed a daily 2-week bowel symptom diary, the Hospital Anxiety and Depression score, and the Patient Health Questionnaire-12 Somatic Symptom score and underwent unprepared flexible sigmoidoscopy. Sigmoid mucosal biopsies were separately evaluated using immunohistochemistry and culture supernatants to determine cellularity, mediator levels, and ability to stimulate colonic afferent activity.

RESULTS:
Pain severity scores significantly correlated with the daily duration of pain (r = 0.67, P < 0.00001), urgency (r = 0.57, P < 0.0005), and bloating (r = 0.39, P < 0.05), but not with psychological symptom scores for anxiety, depression, or somatization. Furthermore, pain severity scores from individual patients with IBS-D were significantly correlated (r = 0.40, P < 0.008) with stimulation of colonic afferent activation mediated by their biopsy supernatant, but not with biopsy cell counts nor measured mediator levels.

DISCUSSION:
Peripheral pronociceptive changes in the bowel seem more important than psychological factors in determining pain severity within a tightly phenotyped cohort of patients with IBS-D. No individual mediator was identified as the cause of this pronociceptive change, suggesting that nerve targeting therapeutic approaches may be more successful than mediator-driven approaches for the treatment of pain in IBS-D.
Monitoring and diagnostics of special-purpose turbomachines
Authors: Małgorzata Gizelska  
Published: February 2021

Abstract
In the operation of special-purpose turbomachines,
diagnostic tools are necessary. They enable control
of the machine technical state and its operation parameters
in the on-line mode. The acquisition and processing of
the measurement data in real time is crucial as they are indicators
of the machine functioning under various operating
conditions. The paper presents two types of computer
designed diagnostic tools to monitor in real time the dynamic
and thermodynamic parameters of special-purpose
turbomachines. The first one monitors the dynamics of the
rotating system with an active magnetic bearing, the second
- monitors the instant value of polytropic efficiency of
the compression process, which was designed for the industrial
machine.
On Convergence Subsystems of Orthonormal Systems
Authors: Bareladze G. 
Published: February 2021

Abstract
It is proved that for any sequence of real numbers satisfying Rk
≥ k (k ≥ 1) and Rk
= o(k log2
k), k → ∞, there exists a orthonormal system , x ∈ (0; 1), such that none of its subsystems with nk ≤ Rk
(k ≥ 1) is a convergence subsystem.
Regular Fréchet–Lie Groups of Invertible Elements in Some Inverse Limits of Unital Involutive Banach Algebras
Authors: Marion Jean , Robart Thierry 
Published: February 2021

Abstract
We consider a wide class of unital involutive topological algebras provided with a C*-norm and which are inverse limits of sequences of unital involutive Banach algebras; these algebras are taking a prominent position in noncommutative differential geometry, where they are often called unital smooth algebras. In this paper we prove that the group of invertible elements of such a unital solution smooth algebra and the subgroup of its unitary elements are regular analytic Fréchet–Lie groups of Campbell–Baker–Hausdorff type and fulfill a nice infinite-dimensional version of Lie's second fundamental theorem.
Computing Gauss–Manin Systems for Complete Intersection Singularities Sμ
Authors: Aleksandrov A. G. , Tanabé S. 
Published: February 2021

Abstract
The Gauss–Manin systems with coefficients having logarithmic poles along the discriminant sets of the principal deformations of complete intersection quasihomogeneous singularities Sμ
are calculated. Their solutions in the form of generalized hypergeometric functions are presented.
Absolute Summability Factors and Absolute Tauberian Theorems for Double Series and Sequences
Authors: Yanetz (Chachanashvili) Sh. 
Published: February 2021

Abstract
Let 𝐴 and 𝐵 be the linear methods of the summability of double series with fields of bounded summability and , respectively. Let 𝑇 be certain set of double series. The condition 𝑥 ∈ 𝑇 is called 𝐵𝑏-Tauberian for 𝐴 if .
Some theorems about summability factors enable one to find new 𝐵𝑏-Tauberian conditions for 𝐴 from the already known 𝐵𝑏-Tauberian conditions for 𝐴.
Convergence to Zero and Boundedness of Operator-Normed Sums of Random Vectors with Application to Autoregression Processes
Authors: Buldygin V. V. , Koval V. A. 
Published: February 2021

Abstract
The problems of almost sure convergence to zero and almost sure boundedness of operator-normed sums of different sequences of random vectors are studied. The sequences of independent random vectors, orthogonal random vectors and the sequences of vector-valued martingale-differences are considered. General results are applied to the problem of asymptotic behaviour of multidimensional autoregression processes.
Towards an Innovation Theory of Spatial Brownian Motion under Boundary Conditions
Authors: Khmaladze E. 
Published: February 2021

Abstract
Set-parametric Brownian motion b in a star-shaped set G is considered when the values of b on the boundary of G are given. Under the conditional distribution given these boundary values the process b becomes some set-parametrics Gaussian process and not Brownian motion. We define the transformation of this Gaussian process into another Brownian motion which can be considered as “martingale part” of the conditional Brownian motion b and the transformation itself can be considered as Doob–Meyer decomposition of b. Some other boundary conditions and, in particular, the case of conditional Brownian motion on the unit square given its values on the whole of its boundary are considered.
Sample Behavior and Laws of Large Numbers for Gaussian Random Elements
Authors: Ergemlidze Z. , Shangua A. , Tarieladze V. 
Published: February 2021

Abstract
Criteria for almost sure boundedness and convergence to zero almost surely of Banach space valued independent Gaussian random elements are found. The obtained statements can be viewed as vector-valued versions of the corresponding results due to N. Vakhania. Moreover, from the obtained statements a strong law of large numbers is derived in the form of Yu. V. Prokhorov.
Generalized Bernoulli Polynomials Revisited and Some Other Appell Sequences
Authors: Maroni Pascal , Mejri Manoubi 
Published: February 2021

Abstract
We study the problem posed by Nörlund in terms of dual sequences. We determine the functional equation fulfilled by the canonical form of any generalized Bernoulli sequence. Surprisingly these canonical forms are positive definite. Some results are given for an Euler sequence.
On the Measurability of Additive Functionals
Authors: Kharazishvili Alexander 
Published: February 2021

Abstract
For an infinite-dimensional separable Hilbert space 𝐻, the problem of measurability of additive functionals 𝑓 : 𝐻 → 𝐑 with respect to various extensions of σ-finite diffused Borel measures on 𝐻 is discussed. It is shown that there exists an everywhere discontinuous additive functional 𝑓 on 𝐻 such that, for any σ-finite diffused Borel measure μ on 𝐻, this 𝑓 can be made measurable with respect to an appropriate extension of μ. Special consideration is given to the case where μ is invariant or quasiinvariant under a subgroup of 𝐻.
Generating Relations of Hermite–Tricomi Functions Using a Representation of Lie Algebra 𝑇3
Authors: Dattoli Giuseppe , Khan Subuhi , Yasmin Ghazala 
Published: February 2021

Abstract
Motivated by recent studies of the properties of new classes of polynomials constructed in terms of quasi-monomials, certain generating relations involving Hermite–Tricomi functions are obtained. To accomplish this we use the representation 𝑄(𝑤, 𝑚0) of the 3-dimensional Lie algebra 𝑇3. Some special cases are also discussed.
Restriction Theorems for Anisotropically Homogeneous Hypersurfaces of
Authors: Ferreyra Elida , Urciuolo Marta 
Published: February 2021

Abstract
For and β
1, . . . , β
𝑛 > 1 let be defined by , let 𝐵 be the open unit ball in and let ∑ = {(𝑥, φ (𝑥)) : 𝑥 ∈ 𝐵}. For let 𝑅𝑓 : ∑ → ℂ be defined by

where denotes the usual Fourier transform of 𝑓. Let σ be the Borel measure on ∑ defined by σ (𝐴) = ∫𝐵
χ
𝐴 (𝑥, φ (𝑥)) 𝑑𝑥 and 𝐸 be the type set for the operator 𝑅, i.e. the set of pairs for which there exists 𝑐 > 0 such that for all . In this paper we obtain a polygonal domain contained in 𝐸. We also give necessary conditions for a pair . In some cases this result is sharp up to endpoints.
Uniqueness of Entire or Meromorphic Functions Concerning Differential Polynomials
Authors: Chen Jun-Fan , Lin Wei-Chuan , Zhang Xiao-Yu 
Published: February 2021

Abstract
We study the uniqueness problems on entire or meromorphic functions concerning differential polynomials that share one slowly growing meromorphic function. Furthermore, we greatly improve and generalize some former results obtained by Fang and Hong, Lin and Yi, Xiong and Lin.
On Functional Equations Connected with Quadrature Rules
Authors: Koclęga-Kulpa Barbara , Szostok Tomasz , Wąsowicz Szymon 
Published: February 2021

Abstract
The functional equations of the form

are considered. They are connected with quadrature rules of the approximate integration. We show that such equations characterize polynomials in the class of continuous functions. It is also shown that if the number of components is sufficiently small, then the continuity is forced by the equation itself. Unique solvability of the considered problem are established.
In vitro CAPITULUM INDUCTION ON SHOOT CULTURES OF Helianthus SPECIES / INDUCCION IN VITRO DE LA CABEZA DEL CULTIVO DE VASTAGO EN LA ESPECIE DEL GENERO Helianthus / INDUCTION DU CAPITULE IN VITRO À PARTIR DE CULTURES DE POUSSES DE LA FAMILLE Helianthus
Authors: Sujatha M. , Prabakaran A.J. 
Published: February 2021

SUMMARY
Premature flowering of shoots is a serious problem in tissue cultures of cultivated sunflower. The ability of cultivated and wild sunflowers and some interspecific hybrids to flower in vitro was compared by maintaining shoot cultures on Murashige and Skoog (MS) medium supplemented with 0.2 to 1.0 mg/ 1 of kinetin or benzyladenine (BA). Studies with 18 accessions comprising diploid annuals, diploid perennials, tetraploids, hexaploids and few interspecific hybrids revealed that capitulum induction in vitro is confined to diploid annuals with determinate apex and interspecific hybrids involving the diploid species.
STUDY ON AN Ambrosia ISOLATE OF Plasmopara halstedii / ESTUDIO DE UN AISLADO DEL HONGO Plasmopara halstedii EN LA ESPECIE Ambrosia / ÉTUDE D’UN ISOLAT DU CHAMPIGNON Plasmopara halstedii SUR L’ESPÈCE Ambrosia
Authors: Walcz Ilona , Bogár Katalin , Virányi Ferenc 
Published: February 2021

SUMMARY
In 1998, a number of Ambrosia artemisifolia individuals located in the vicinity of a sunflower breeding nursery at Bicsérd, south Hungary, showed disease symptoms resembling downy mildew and/or white rust. Sporangia of both Plasmopara and Albugo have been isolated from the affected plants. Microscopical observations and subsequent inoculation experiments revealed the existence of Plasmopara halstedii on the affected A.artemisifolia plants. Following inoculations on a set of sunflower differentials, the Ambrosia isolates of P.halstedii consistently showed a virulence formula of 730 that is equal to pathotype 4.
Laboratory Study on Oxide Inclusions in High-Strength Low-Alloyed Steel Refined by Slag with Basicity 2–5
Authors: Yu Huixiang , Wang Xinhua , Zhang Jing , Wang Wanjun 
Published: February 2021

Abstract
Non-metallic inclusions in high-strength low-alloyed steel refined by slag with basicity (B) 2–5 and Al2O3 content 20%–30% (in mass percent) were investigated by slag–metal equilibrium experiments in laboratory and thermodynamic calculations. Most inclusions in equilibrium were quasi-spherical CaO-MgO-Al2O3-SiO2 system and the sizes were less than 5 µm. The average content ratio, CaO/Al2O3 and CaO/SiO2 of the inclusions, increased with slag basicity increasing when Al2O3 content in slag was around 25%, MgO/Al2O3 and CaO/Al2O3 increased with Al2O3 content in slag decreasing when slag basicity was around 3.3. The MgO/Al2O3 of the inclusions was influenced mainly by Al2O3 content in slag and CaO/Al2O3 was influenced mainly by slag basicity. To make the inclusions out of relative lower melting region (<1,773 K), the values of CaO/Al2O3, MgO/Al2O3 and (CaO+MgO)/Al2O3 of the inclusions should be enhanced by increasing basicity and decreasing Al2O3 content in slag properly.
The influence of multi-pass friction stir processing on microstructure and sliding wear behavior of Cu/ZrO2 surface composite
Authors: Rabiezadeh Amin , Ghafaei Saman 
Published: February 2021

Abstract
In this study, copper/ZrO2 surface composites were produced using nano-particles via friction stir processing in order to enhance surface tribological properties. The present research aimed to generate copper matrix composites and analyze the effect of processing parameters on the evolving microstructure, microhardness, and wear-resistance behavior. It is worth noting that the processed composite layer had more homogeneity in the four-pass process. In comparison to the base metal and non-powder samples, it had higher mechanical characteristics. Based on the results, the highest recorded hardness, approximately 288 HV, was found in a four-pass state with powder. Remarkably, it showed a double peak compared to 80 HV in the base metal. The lowest friction coefficient of four-passes with the powder sample was about 0.47, which showed a significant efficiency in comparison to the friction coefficient of base metal that was about 0.81.
Mechanical bonding in cold roll-cladding of tri-layered brass/steel/brass composite
Authors: Vaseghi Majid , Zand Hossein , Sameezadeh Mahmood 
Published: February 2021

Abstract
In this paper, brass/steel/brass clad-composite was fabricated using a cold roll-bonding process. Composite sheets were roll-bonded at reduction ratios between 37 and 72% at room temperature from strips of 150 mm in length and 30 mm wide, in one pass without lubrication. The threshold deformation for successful bonding was at a thickness reduction of 48% and peel strengths of the bonds were measured to be approximately 12 N cm-1, and it was found to escalate with an increase in the rolling reduction. The optimum reduction in thickness was ~66% wherein the peel strength was ~33 N cm-1. Various techniques such as optical and electron microscopy were implemented to analyze and investigate the effects of the reduction in thickness and the joining mechanism. The results showed that an increased reduction in thickness in rolling leads to an increase in the joining strength. Furthermore, increasing the brass plate thickness negatively affects the joining strength. A Cu peak on the peeled-off steel surface and the presence of Fe on the peeled-off brass surface strongly suggest that the major bonding between brass and steel was mechanically induced metallurgical bonding.
Analysis of Thermoviscoplastic Effects on Dynamic Necking of Pure Copper Bars during Impact Tension
Authors: Ma Dongfang , Chen Danian , Shanxing Wu , Wang Huanran , Hou Yanjun , Cai Canyuan , Deng Gaotao 
Published: February 2021

Abstract
In order to make effective measure for the stress, strain and strain rate in the specimen, a tensile split Hopkinson bar (TSHB) was optimized in the first loading duration and the thermoviscoplastic models for a pure copper were determined. The deformation of the pure copper bar during the multi-tensile loading including the necking process in the optimized TSHB testing was recorded by a high speed camera and was used in providing an extensional check of the determined thermoviscoplastic models of the pure copper. The thermoviscoplastic models determined in a certain range of strain were employed in numerically simulating the large deformation of the pure copper bar to adjust the thermoviscoplastic model to describing large strain range. The instability strain of thermoviscoplastic materials in simple tension given by Batra et al was compared with the experimental strain at diffuse necking of the pure copper bar and the computed instability strain based on the load-average strain of the pure copper bar. The local necking of the pure copper bar in the optimized TSHB testing was numerically simulated using the micro-mechanical data given by Ragab and was compared with the recorded necking.
Church, State and Secularism in Asia: The Public Nature of the Church in Timor-Leste
Authors: Hodge Joel 
Published: February 2021

Abstract
The Western discourse and norms around secularism, particularly Church-state relations, are foreign in many ways to the majority world, especially Asia. However, as the modern nation-state has taken root in Asia, different models of secularism have developed with interesting relationships to the particular cultural and religious context of each country. In the difficult course of forming a secular nation-state, Asian nations have had to address the dominant religious traditions and institutions of each nation, including Christian churches. This process has occasionally provoked conflict and has presented a particular dilemma to Christian churches in how to respond and relate to the developing nation-state. In order for theology to adequately address this situation (particular the context of modern secular discourses) and conceptualise the public shape and role of the church, a practical examination of the church’s relationship to and formation of culture and politics is required. To explore this process, this essay examines the case of Timor-Leste (or East Timor) and its relationship with the Roman Catholic Church, particularly in regards to the state-building process that has occurred after independence. The Church’s influence, which grew rapidly during the Indonesian occupation (1975–1999), has been contested since independence by some in the political sphere, such as in the 2005 dispute with the Government. By examining the 2005 dispute, the essay analyses the nature of the Catholic Church’s influence on Timorese cultural and political identity and her relationship with the new Timorese nation-state. The essay identifies the different models of secularism operative in Timor as they have relevance to the Asian context more generally.
Religion – Alter – Demenz
Authors: Charbonnier Lars , Roy Lena-Katharina 
Published: February 2021

Abstract
The demographic future offers intensive challenges for society as present in Germany not only with regard to the social or economic system, but also with regard to religion and the Christian church’s practice in its different fields. This research report presents the current state of research on religion and aging as far as it is relevant for practical-theological reflection, mostly limited to German-speaking context. The perspective of gerontology is considered as well as research from sociology and psychology of religion or reflections on the fields of church practice like pastoral care and counselling or education/life-long-learning. A special focus is set on the specific challenges arising for theological reflection as well as church-practice from the phenomena of dementia.
The Descendants of the Sîn-lēqi-unnīnī during the Late Achaemenid and Early Hellenistic Periods – A Family of Priests, Scribes and Scholars and Their Archival and Learned Texts
Authors: Hackl Johannes , Oelsner Joachim 
Published: February 2021

AbstractIt is by now well established that authors and copyists of scholarly works also drafted legal documents, if only occasionally. This article examines newly available prosopographical information concerning the scribal activities of the Sîn-lēqi-unnīnī during the mid to late fourth century BCE. It offers new datings of learned texts that have been known to academic circles for a long time and argues that the extant archival texts from Early Hellenistic Uruk mainly belonged to the archives of the Aḫûtu and Ekur-zakir families. In addition, it presents cases of transference of linguistic items peculiar to one or the other genre, giving rise to some general remarks on cross-genre imprints.