bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elastic stent recoil in coronary total occlusions: Comparison of durable‐polymer zotarolimus eluting stent and ultrathin strut bioabsorbable‐polymer sirolimus eluting stent
Authors: Improta Riccardo , Scarparo Paola , Wilschut Jeroen , Wolff Quinten , Daemen Joost , Den Dekker Wijnand K , Zijlstra Felix , Van Mieghem Nicolas M , Diletti Roberto 
Published: May 2021

AbstractObjectivesTo compare stent recoil (SR) of the thin‐strut durable‐polymer Zotarolimus‐eluting stent (dp‐ZES) and the ultrathin‐strut bioabsorbable‐polymer Sirolimus‐eluting stent (bp‐SES) in chronic total occlusions (CTOs) and to investigate the predictors of high SR in CTOs.BackgroundNewer ultrathin drug eluting stent might be associated with lower radial force and higher elastic recoil due to the thinner strut design, possibly impacting on the rate of in‐stent restenosis and thrombosis.MethodsBetween January 2017 and November 2019, consecutive patients with CTOs undergoing percutaneous coronary intervention were evaluated. Only patients treated with dp‐ZES or bp‐SES were included and stratified accordingly. Quantitative coronary angiography analysis was used to assess absolute SR, relative SR, absolute focal SR, relative focal SR, high absolute, and high relative focal SR.ResultsA total of 128 lesions (67 treated with dp‐ZES and 61 with bp‐SES) in 123 patients were analyzed. Between bp‐SES and dp‐ZES no differences were found in absolute SR (p = .188), relative SR (p = .138), absolute focal SR (p = .069), and relative focal SR (p = .064). High absolute and high relative focal SR occurred more frequently in bp‐SES than in dp‐ZES (p = .004 and p = .015). Bp‐SES was a predictor of high absolute focal SR (Odds ratio [OR] 3.29, 95% confidence interval [CI] 1.50–7.22, p = .003]. High‐pressure postdilation and bp‐SES were predictors of high relative focal SR (OR 2.22, 95% CI 1.01–4.86, p = .047; OR 2.74, 95% CI 1.24–6.02, p = .012, respectively).ConclusionsBoth stents showed an overall low SR. However, ultra‐thin strut bp‐SES was a predictor of high absolute and high relative focal SR.
Outcomes of rotational atherectomy for severely calcified coronary lesions: A single center 5‐year experience
Authors: Gao Wei , Chen Yaolin , Yang Hongbo , Yao Kang , Ge Junbo 
Published: May 2021

AbstractObjectivesThe aim of this study was to investigate the influences of accumulated experience on rotational atherectomy (RA) operation regarding to in‐hospital outcomes in the drug‐eluting stent (DES) era.MethodsBetween 2015 and 2019, 540 de novo lesions with calcified coronary lesions treated by RA and DES implantation at our center were retrospectively assessed. In‐hospital major adverse cardiac events (MACE) were defined as all cause death, cardiac death, target vessel revascularization, and stroke.ResultsFrom 2015 to 2019, RA operations were 22, 60, 102, 157, and 199 cases, respectively. Rates of procedural complications were 4.5, 3.3, 11.8, 8.3, and 7.5%, respectively. Rates of in‐hospital MACE were 0, 0, 3.9, 2.5, and 2.0%, respectively. Compared with planned RA, bailout RA was associated with more contrast use (207.5 ± 82.8 ml vs. 189.2 ± 70.0 ml, p = .008). As for procedural complications and in‐hospital outcomes, no differences were observed between two strategies. Logistic regression revealed that hypertension was independently associated with complications (OR 5.830, 95% CI 1.382–24.591, p = .016). For MACE, independent risk factors were heart failure (OR 17.593, 95% CI 1.475–209.816, p = .023) and procedural complications (OR 127.629, 95% CI 15.135–1,076.258, p < .001).ConclusionsAlong with the rapid increase of RA use and accumulated experience, rates of complications and MACE went up first and then dropped down. Hypertension was found to be an independent risk factor of procedural complications. For in‐hospital MACE, independent risk factors were heart failure and procedural complications.
Percutaneous mechanical circulatory support from the collaborative multicenter Mechanical Unusual Support in TAVI (MUST) Registry
Authors: Orvin Katia , Perl Leor , Landes Uri , Dvir Danny , Webb John George , Stelzmüller Marie‐Elisabeth , Wisser Wilfried , Nazif Tamim Michael , George Isaac , Miura Mizuki , Taramasso Maurizio , Pilgrim Thomas , Fürholz Monika , Sinning Jan‐Malte , Nickenig Georg , Rumer Chris , Tarantini Giuseppe , Masiero Giulia , Bunc Matjas , Radsel Peter , Latib Azeem , Kargoli Faraj , Ielasi Alfonso , Medda Massimo , Nombela‐Franco Luis , Vaknin‐Assa Hana , Kornowski Ran 
Published: May 2021

AbstractObjectivesTo evaluate the use and outcomes of percutaneous mechanical circulatory support (pMCS) utilized during transcatheter aortic valve implantation (TAVI) from high‐volume centers.Methods and resultsOur international multicenter registry including 13 high‐volume TAVI centers with 87 patients (76.5 ± 11.8 years, 63.2% men) who underwent TAVI for severe aortic stenosis and required pMCS (75.9% VA‐ECMO, 19.5% Impella CP, 4.6% TandemHeart) during the procedure (prior to TAVI 39.1%, emergent rescue 50.6%, following TAVI 10.3%). The procedures were considered high‐risk, with 50.6% having severe left ventricular dysfunction, 24.1% biventricular dysfunction, and 32.2% severe pulmonary hypertension. In‐hospital and 1‐year mortality were 27.5% and 49.4%, respectively. Patients with prophylactic hemodynamic support had lower periprocedural mortality compared to patients with rescue insertion of pMCS (log rank = 0.013) and patients who did not undergo cardiopulmonary resuscitation during the TAVI procedure had better short and long term survival (log rank <0.001 and 0.015, respectively).ConclusionsGiven the overall survival rate and low frequency of pMCS‐related complications, our study results support the use of pMCS prophylactically or during the course of TAVI (bailout) in order to improve clinical outcomes in high‐risk procedures or in case of acute life‐threatening hemodynamic collapse.
Key Parameters for the Synthesis of Active and Selective Nanostructured 3d Metal Catalysts Starting from Coordination Compounds – Case Study: Nickel Mediated Reductive Amination
Authors: Klarner Mara , Blach Patricia , Wittkämper Haiko , de Jonge Niels , Papp Christian , Kempe Rhett 
Published: May 2021

AbstractThe design of nanostructured catalysts based on earth‐abundant metals that mediate important reactions efficiently, selectively and with a broad scope is highly desirable. Unfortunately, the synthesis of such catalysts is poorly understood. We report here on highly active Ni catalysts for the reductive amination of ketones by ammonia employing hydrogen as a reducing agent. The key functions of the Ni‐salen precursor complex during catalyst synthesis have been identified: (1) Ni‐salen complexes sublime during catalyst synthesis, which allows molecular dispersion of the metal precursor on the support material. (2) The salen ligand forms a nitrogen‐doped carbon shell by decomposition, which embeds and stabilizes the Ni nanoparticles on the γ‐Al2O3 support. (3) Parameters, such as flow rate of the pyrolysis gas, determine the carbon supply for the embedding process of Ni nanoparticles.
Electrochemical Cleavage of Carbon‐Chlorine Bonds in Multiply Bridge‐Chlorinated Bicyclo[1.1.1]pentane‐1,3‐dicarboxylic Acids
Authors: Kaleta Jiří , Hromadová Magdaléna , Pospíšil Lubomír 
Published: May 2021

AbstractReduction of five derivatives of bicyclo[1.1.1]pentane‐1,3‐dicarboxylic acid containing one to four chlorine substituents on methylene bridges were investigated by cyclic voltammetry and electrochemical impedance spectroscopy. Electrochemical cleavage of C−Cl bonds and the reduction of H+ provided by dissociation of COOH groups are two competing processes characterized by different time constants. A concerted mechanism of C−Cl bonds cleavage is operative. The location of LUMO orbitals changes with increasing number of chlorine substituents from COOH sites to bicyclo[1.1.1]pentane. Carboxylic groups participate in the protonation of intermediates formed by the C−Cl bond rupture. The esterification of two derivatives eliminates the self‐protonation. Esters are reduced only at very negative potentials near the end of an available potential window.
Ionic Diode and Molecular Pump Phenomena Associated with Caffeic Acid Accumulated into an Intrinsically Microporous Polyamine (PIM‐EA‐TB)
Authors: Li Zhongkai , Wang Lina , Malpass‐Evans Richard , Carta Mariolino , McKeown Neil B. , Mathwig Klaus , Fletcher Philip J. , Marken Frank 
Published: May 2021

AbstractThe polymer of intrinsic microporosity PIM‐EA‐TB provides a molecularly rigid micropore structure containing tertiary amine sites and is shown here to interact with hydrogen bonding guest molecules such as caffeic acid. Voltammetric data with a PIM‐EA‐TB film on glassy carbon electrodes show that in both acidic solution (pH 2; PIM‐EA‐TB is protonated) and in neutral solution (pH 6; PIM‐EA‐TB is not protonated) caffeic acid is slowly accumulated into the microporous host. Binding constants are estimated and suggested to be linked to hydrogen bonding causing accumulation of caffeic acid. When employing PIM‐EA‐TB as an asymmetric membrane coated onto a 5 μm thick Teflon support film with 10 μm diameter microholes (using either a single microhole or a 10×10 array of microholes), binding of caffeic acid is shown to cause a modulation of the ionic current without affecting the pH‐dependent ionic diode behaviour. Two complementary types of effects of caffeic acid guests are discussed based on blocking anion diffusion pathways and based on removal of positive charges. The caffeic acid transport mechanism/efficiency is investigated in view of selective molecular pumping.
Rational Design of a ZIF‐67/Cobalt‐Glycolate Heterostructure with Improved Conductivity for High Cycling Stability and High‐Capacity Lithium Storage
Authors: Song Juanjuan , He Bin , Shen Honglong , Wu Zongdeng , Yu Jia , Lei Wu , Xia Xifeng , Du Ping , Hao Qingli 
Published: May 2021

AbstractCobalt‐glycolate (Co‐glycolate) is a kind of layered coordination polymer with abundant electrochemically active sites but low conductivity. The fabrication of heterostructures is a novel strategy to enhance the electrical conductivity. Herein, Co‐glycolate serves as a host substrate for the in situ growth of guest ZIF‐67 to build MOFs‐on‐CPs heterostructures (named Co‐glycolate /ZIF‐67) via a simple ligand‐exchange method as an anode for lithium‐ion batteries. A heterojunction interface with distorted lattice between the Co‐glycolate phase and the ZIF‐67 phase can be observed. Theoretical calculations and experimental results simultaneously prove that the formed heterojunction reduces the band gap and enhances the conductivity. Compared with both single components, optimized Co‐glycolate/ZIF‐67 shows a higher capacity and better cycling and rate performances due to the improved charge‐transfer rate of the heterostructure. Its specific capacity remains at 652 mAh g−1 after 800 cycles at 1 A g−1. These excellent electrochemical properties can be due to the smaller size, rough surface, and strong combination of a unique heterostructure as well as to the greatly reduced band gap of the individual components. A lithium‐storage mechanism for Co‐glycolate/ZIF‐67 was proposed. This work provides a new strategy for building MOFs‐on‐CPs heterostructures to improve the electrochemical performance of metal‐glycolate‐based electrode materials for energy‐storage and conversion systems.
The critical role of inorganic nanofillers in solid polymer composite electrolyte for Li+ transportation
Authors: Shen Zhichuan , Cheng Yifeng , Sun Shuhui , Ke Xi , Liu Liying , Shi Zhicong 
Published: May 2021

AbstractCompared with commercial lithium batteries with liquid electrolytes, all‐solid‐state lithium batteries (ASSLBs) possess the advantages of higher safety, better electrochemical stability, higher energy density, and longer cycle life; therefore, ASSLBs have been identified as promising candidates for next‐generation safe and stable high‐energy‐storage devices. The design and fabrication of solid‐state electrolytes (SSEs) are vital for the future commercialization of ASSLBs. Among various SSEs, solid polymer composite electrolytes (SPCEs) consisting of inorganic nanofillers and polymer matrix have shown great application prospects in the practice of ASSLBs. The incorporation of inorganic nanofillers into the polymer matrix has been considered as a crucial method to achieve high ionic conductivity for SPCE. In this review, the mechanisms of Li+ transport variation caused by incorporating inorganic nanofillers into the polymer matrix are discussed in detail. On the basis of the recent progress, the respective contributions of polymer chains, passive ceramic nanofillers, and active ceramic nanofillers in affecting the Li+ transport process of SPCE are reviewed systematically. The inherent relationship between the morphological characteristics of inorganic nanofillers and the ionic conductivity of the resultant SPCE is discussed. Finally, the challenges and future perspectives for developing high‐performance SPCE are put forward. This review aims to provide possible strategies for the further improvement of ionic conductivity in inorganic nanoscale filler‐reinforced SPCE and highlight their inspiration for future research directions.
Study of Ground State Interactions of Enantiopure Chiral Quaternary Ammonium Salts and Amides, Nitroalkanes, Nitroalkenes, Esters, Heterocycles, Ketones and Fluoroamides
Authors: Bencivenni Grazia , Salazar Illera Diana , Moccia Maria , Houk K. N. , Izzo Joseph A. , Novacek Johanna , Grieco Paolo , Vetticatt Mathew J. , Waser Mario , Adamo Mauro F. A. 
Published: May 2021

AbstractChiral phase‐transfer catalysis provides high level of enantiocontrol, however no experimental data showed the interaction of catalysts and substrates. 1H NMR titration was carried out on Cinchona and Maruoka ammonium bromides vs. nitro, carbonyl, heterocycles, and N−F containing compounds. It was found that neutral organic species and quaternary ammonium salts interacted via an ensemble of catalyst +N−C−H and (sp2)C−H, specific for each substrate studied. The correspondent BArF salts interacted with carbonyls via a diverse set of +N−C−H and (sp2)C−H compared to bromides. This data suggests that BArF ammonium salts may display a different enantioselectivity profile. Although not providing quantitative data for the affinity constants, the data reported proofs that chiral ammonium salts coordinate with substrates, prior to transition state, through specific C−H positions in their structures, providing a new rational to rationalize the origin of enantioselectivity in their catalyses.
Positive basophil activation test with soymilk protein identifies Gly m 4–related soymilk allergy
Authors: Yoshida Tokiko , Chinuki Yuko , Matsuki Shingo , Morita Eishin 
Published: May 2021

AbstractSoymilk allergy is caused by cross‐reaction of either birch Bet v 1–specific or alder Aln g 1–specific IgE to soybean Gly m 4, which belongs to pathogenesis‐related protein‐10 (PR‐10) family. Gly m 4–specific IgE test identifies soybean allergy patients with high sensitivity. In this case study, we found that CD203c expression–based basophil activation test (CD203c‐BAT) with soymilk protein became positive in the three cases of Gly m 4–related soymilk allergy at the concentrated of 1 μg/ml, but not in the control subjects. CD203c‐BAT may possibly be useful as a diagnostic tool to identify patients with soymilk allergy.
Maximum solid concentrations of coal wastewater slurries predicted by optimized neural network based on wastewater composition data
Authors: Li Dedi , Liu Jianzhong , Chen Cong , Liu He , Lv Hanjing , Cheng Jun 
Published: May 2021

AbstractA variety of wastewaters can be generated in the coal chemical industry, and their treatment processes are complicated and have difficulty meeting standards. Using wastewater to prepare coal water slurry is an efficient and convenient new approach. The concentration of coal wastewater slurry is related to the content of the main wastewater components. A backpropagation neural network is developed to predict the maximum slurry concentration and analyze the mechanism at the data level according to the main component indicators, and a particle swarm algorithm is used to improve the neural network. The results are as follows: (a) it is feasible to predict the maximum concentration of coal wastewater slurry by a neural network, and a particle swarm algorithm can effectively improve the prediction accuracy in different models, reducing mean absolute error by up to 0.44%; (b) different input factors have different impacts on model prediction results—organic matter, ammonia nitrogen, and monovalent metal ions content as input factors to predict the maximum slurry concentration can get the most accurate results, obtaining a mean absolute error of 0.16% for the optimized backpropagation neural network and the lowest mean square error; and (c) divalent metal ions and phenols content are not suitable as input factors for predicting, as they all cause an increase in model error due to their weak or complex effects on the slurryability.
Rh(III)‐Catalyzed Diverse C—H Functionalization of Iminopyridinium Ylides
Authors: Dong Zhenzhen , Li Pengfei , Li Xingwei , Liu Bingxian 
Published: May 2021

Main observation and conclusionDivergent synthesis of useful skeletons has been realized via rhodium(III)‐catalyzed C—H activation of iminopyridinium ylides and coupling with various unsaturated coupling reagents. Isocoumarins and isoquinolones were obtained via cleavage of the C—N or N—N bond in the ylidic directing group, while fluorinated alkenes were delivered with the directing group intact. The reactions occurred with wide substrate scopes and good efficiency under redox‐neutral and air‐tolerant conditions. Representative products exhibit solid‐state fluorescent property and bioactivity of inhibition toward human cancer cells.
Enantioselective Resolution Copolymerization of Racemic 2,3‐Disubstituted cis‐Epoxides with CO2 Mediated by Binuclear Cobalt(III) Catalyst†
Authors: Liu Yan‐Lan , He Guang‐Hui , Liu Ye , Lu Xiao‐Bing 
Published: May 2021

Main observation and conclusionEnantioselective resolution copolymerization of racemic internal epoxides with carbon dioxide (CO2) is a challenging issue because of their poor reactivity and complicated regio/stereoselectivity. Herein, we describe the first enantioselective resolution copolymerization of racemic aromatic 2,3‐disubstituted cis‐epoxides and CO2 using enantiopure dinuclear cobalt(III) complexes as catalyst under mild conditions, affording the corresponding polycarbonates with completely alternating structure and good enantioselectivity in the range of 70% to 97% ee. The isotactic polycarbonate from β‐methylstyrene oxide is a typical semicrystalline material, possessing a melting point of 241 oC; while other isotactic‐enriched copolymers from 2,3‐disubstituted cis‐epoxides bearing a substitute group on the aromatic ring are amorphous, having glass transition temperatures between 86 oC and 124 oC. Interestingly, the copolymer selectivity is correlated well with the Hammett substituent constant, and the highest polymer selectivity of 98% was found in the system using the epoxides bearing an electron‐donating group on the benzene ring.
High Tg Polymer Insulator Yields Organic Photovoltaic Blends with Superior Thermal Stability at 150 oC
Authors: Chen Fei , Zhang Ying , Wang Qi , Gao Mengyuan , Kirby Nigel , Peng Zhongxiang , Deng Yunfeng , Li Miaomiao , Ye Long 
Published: May 2021

Main observation and conclusionRecord‐breaking organic solar cells (OSCs) based on blends of polymer donors and small molecule acceptors often show undesirable degradation, which severely precludes their practical use. Herein, we demonstrate a facile and cost‐effective approach to construct thermally stable OSCs at 150 oC by incorporating a small amount of a polymer insulator polyacenaphthylene (PAC) with high glass‐transition temperature over 230 oC into polymer:acceptor blends. The model PTB7‐Th:EH‐IDTBR blend with 10 wt% PAC maintained above 85% of its initial efficiency upon continuous heating at 150 oC for over 800 h, while the efficiency of the blend without PAC sharply dropped by 70% after ~300 h. Owing to high miscibility with acceptors, PAC confines the motion of the acceptor molecules and suppresses the acceptor crystallization at elevated temperatures, leading to significantly improved stability. Importantly, the effectiveness of this blending approach was also validated in many other OSC systems, showing great potential for achieving high‐performance thermally stable electronics.
Structural Basis of RACK7 PHD Domain to Read a Pediatric Glioblastoma‐Associated Histone Mutation H3.3G34R
Authors: Lan Wenxian , Li Ze , Jiao Fangfang , Wang Chunxi , Guo Rui , Cao Chunyang 
Published: May 2021

Main observation and conclusionHistone point mutations, including missense mutations on histone H3 at positions 27 (K27M), 34 (G34R/V, G34W, G34L) and 36 (K36M), were identified as potential cancer driver mutations. H3.3G34R/V mutations account for pediatric glioblastomas (GBM). RACK7 (also known as ZMYND8, PRKCBP1) was recently reported to specifically bind H3.3G34R through its PHD (plant homedomain) domain (PHDRACK7) in vitro and in H3.3G34R pediatric glioblastoma cells, playing key roles in H3.3G34R‐mediated gene transcription. Herein, we provided both biochemical and NMR structural evidences that PHDRACK7 recognized histone H3.3G34R mutant via a mechanism distinct from all other reported PHD domains. Except the reported residue D104, two new sites D108 and L121 of PHDRACK7 were found necessary for the interactions between PHDRACK7 and histone H3.3G34R peptide. Our results provided a potential molecular basis for pediatric GBM driven by the H3.3G34R mutation.
Mode of death in elderly and super‐elderly patients with acute heart failure: Insights from Japanese heart failure registry
Authors: Takabayashi Kensuke , Kitaguchi Shouji , Yamamoto Takashi , Takenaka Kotoe , Takenaka Hiroyuki , Fujita Ryoko , Okuda Miyuki , Nakajima Osamu , Koito Hitoshi , Terasaki Yuka , Kitamura Tetsuhisa , Nohara Ryuji 
Published: May 2021

AbstractBackgroundIn Japan, both the prevalence of the elderly and super‐elderly and those of acute heart failure (AHF) have been increasing rapidly.MethodsThis registry was a prospective multicenter cohort, which enrolled a total of 1253 patients with AHF. In this study, 1117 patients' follow‐up data were available and were categorized into three groups according to age: <75 years old (nonelderly), 75–84 years old (elderly), and ≥ 85 years old (super‐elderly). The endpoint was defined as all‐cause death and each mode of death after discharge during the 3‐years follow‐up period.ResultsBased on the Kaplan–Meier analysis, a gradually increased risk of all‐cause death according to age was found. Among the three groups, the proportion of HF death was of similar trend; however, the proportion of infection death was higher in elderly and super‐elderly patients. After adjusting for potentially confounding effects using the Cox and Fine–Gray model, the hazard ratio (HR) of all‐cause death increased significantly in elderly and super‐elderly patients (HR, 2.60; 95% confidence interval [CI], 1.93–3.54 and HR, 5.04; 95% CI, 3.72–6.92, respectively), when compared with nonelderly patients. The highest sub‐distribution HR in detailed mode of death was infection death in elderly and super‐elderly patients (HR, 4.25; 95% CI, 1.75–10.33 and HR, 10.10; 95% CI, 3.78–27.03, respectively).ConclusionsIn this population, the risk of all‐cause death was found to increase in elderly and super‐elderly. Elderly patients and especially super‐elderly patients with AHF were at a higher risk for noncardiovascular death, especially infection death.