bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between serum total testosterone and prostate volume in aging men
Authors: Xia Bo-Wen , Zhao Si-Cong , Chen Zong-Ping , Chen Chao , Liu Tian-Shu , Yang Fan , Yan Yong 
Published: July 2021

AbstractTotal testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.
Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
Authors: Lee Hyunjong , Park Jeongbin , Im Hyung-Jun , Na Kwon Joong , Choi Hongyoon 
Published: July 2021

AbstractThe Coronavirus disease 2019 (COVID-19) has been spreading worldwide with rapidly increased number of deaths. Hyperinflammation mediated by dysregulated monocyte/macrophage function is considered to be the key factor that triggers severe illness in COVID-19. However, no specific targeting molecule has been identified for detecting or treating hyperinflammation related to dysregulated macrophages in severe COVID-19. In this study, previously published single-cell RNA-sequencing data of bronchoalveolar lavage fluid cells from thirteen COVID-19 patients were analyzed with publicly available databases for surface and imageable targets. Immune cell composition according to the severity was estimated with the clustering of gene expression data. Expression levels of imaging target molecules for inflammation were evaluated in macrophage clusters from single-cell RNA-sequencing data. In addition, candidate targetable molecules enriched in severe COVID-19 associated with hyperinflammation were filtered. We found that expression of SLC2A3, which can be imaged by [18F]fluorodeoxyglucose, was higher in macrophages from severe COVID-19 patients. Furthermore, by integrating the surface target and drug-target binding databases with RNA-sequencing data of severe COVID-19, we identified candidate surface and druggable targets including CCR1 and FPR1 for drug delivery as well as molecular imaging. Our results provide a resource in the development of specific imaging and therapy for COVID-19-related hyperinflammation.
Important gender differences in psychosomatic and school-related complaints in relation to adolescent weight status
Authors: Brooks Samantha J. , Feldman Inna , Schiöth Helgi B. , Titova Olga E. 
Published: July 2021

AbstractUnderweight or overweight in adolescence is linked to several adverse health outcomes. Less evidence exists about the association between weight status and school-related psychosocial characteristics in high income countries. We sought to investigate the relationship between weight status and psychosomatic and school-related complaints with a focus on gender differences. The study is a cohort of 18,462 adolescents (12–19 years; 51% girls) conducted in Sweden. The associations between weight status and psychosomatic and school-related complaints were estimated by binary logistic regression adjusted for several potential confounders. After correction for multiple testing, being underweight or overweight/obese was adversely associated with several psychosomatic and school-related complaints with significant differences between boys and girls. Specifically, underweight boys had higher odds to have psychosomatic complaints than normal-weight boys, while no such associations were observed among underweight girls. Overweight/obese (vs. normal-weight) boys had higher odds to complain about headache, pain in the back/hips, and feeling low. Overweight/obese (vs. normal-weight) girls were more likely to complain about feeling low, anxious/worried and having difficulty in falling asleep (P ≤ 0.01). In relation to school-related complaints (e.g., being bullied at school and academic failure), greater associations were observed for overweight/obese girls and boys than for underweight adolescents compared with normal-weight peers.
Effective path prediction and data transmission in opportunistic social networks
Authors: Wu Jia , Zou Wenhao , long Huiyun 
Published: July 2021

AbstractWith the development of social media, social networks have become an important platform for people to share and communicate. In social network communication, when people carry mobile devices for data transmission, they need to find a definite transmission destination to ensure the normal conduct of information exchange activities. This is manifested in the process of data transmission by nodes, which requires analysis and judgment of surrounding areas, and finds suitable nodes for effective data classification and transmission. However, the node cache space in social networks is limited, and the process of waiting for the target node will cause end‐to‐end transmission delay. In order to improve such a transmission environment, this paper proposes a node trajectory prediction method named EDPPM algorithm. The EDPPM algorithm guarantees that nodes with high probability are given priority to obtain data information, which realized an effective data transmission mechanism. Through experiments and comparison of opportunistic transmission algorithms in social networks, such as Epidemic algorithm, Spray and Wait algorithm, and PRoPHET algorithm, the proposed scheme outperforms ProPhet by 47% in terms of cache utilization of nodes, 55% in terms of data transmission delay, and 32% in terms of network efficiency; compared with Epidemic by 53% in terms of cache utilization of nodes, 62% in terms of data transmission delay, and 47% in terms of network efficiency; same thing with regard to the Spray and wait by 27% in terms of cache utilization of nodes, 31% in terms of data transmission delay, and 17% in terms of network efficiency.
The CARMENES search for exoplanets around M dwarfs
Authors: Sabotta S. , Schlecker M. , Chaturvedi P. , Guenther E. W. , Muñoz Rodríguez I. , Muñoz Sánchez J. C. , Caballero J. A. , Shan Y. , Reffert S. , Ribas I. , Reiners A. , Hatzes A. P. , Amado P. J. , Klahr H. , Morales J. C. , Quirrenbach A. , Henning Th. , Dreizler S. , Pallé E. , Perger M. , Azzaro M. , Jeffers S. V. , Kaminski A. , Kürster M. , Lafarga M. , Montes D. , Passegger V. M. , Zechmeister M. 
Published: July 2021

Context. The CARMENES exoplanet survey of M dwarfs has obtained more than 18 000 spectra of 329 nearby M dwarfs over the past five years as part of its guaranteed time observations (GTO) program.
Aims. We determine planet occurrence rates with the 71 stars from the GTO program for which we have more than 50 observations.
Methods. We use injection-and-retrieval experiments on the radial-velocity time series to measure detection probabilities. We include 27 planets in 21 planetary systems in our analysis.
Results. We find 0.06−0.03+0.04 giant planets (100 M⊕ < Mpl sin i < 1000 M⊕) per star in periods of up to 1000 d, but due to a selection bias this number could be up to a factor of five lower in the whole 329-star sample. The upper limit for hot Jupiters (orbital period of less than 10 d) is 0.03 planets per star, while the occurrence rate of planets with intermediate masses (10 M⊕ < Mpl sin i < 100 M⊕) is 0.18−0.05+0.07 planets per star. Less massive planets with 1 M⊕ < Mpl sin i < 10 M⊕ are very abundant, with an estimated rate of 1.32−0.31+0.33 planets per star for periods of up to 100 d. When considering only late M dwarfs with masses M⋆ < 0.34 M⊙, planets more massive than 10 M⊕ become rare. Instead, low-mass planets with periods shorter than 10 d are significantly overabundant.
Conclusions. For orbital periods shorter than 100 d, our results confirm the known stellar mass dependences from the Kepler survey: M dwarfs host fewer giant planets and at least two times more planets with Mpl sin i < 10 M⊕ than G-type stars. In contrast to previous results, planets around our sample of very low-mass stars have a higher occurrence rate in short-period orbits of less than 10 d. Our results demonstrate the need to take into account host star masses in planet formation models.
Solar chromosphere heating and generation of plasma outflows by impulsively generated two-fluid Alfvén waves
Authors: Pelekhata M. , Murawski K. , Poedts S. 
Published: July 2021

Context. We address the heating of the solar chromosphere and the related generation of plasma inflows and outflows.
Aims. We attempt to detect variations in ion temperature and vertical plasma flows, which are driven by impulsively excited two-fluid Alfvén waves. We aim to investigate the possible contribution of these waves to solar chromosphere heating and plasma outflows.
Methods. We performed numerical simulations of the generation and evolution of Alfvén waves with the use of the JOANNA code, which solves the two-fluid equations for ions+electrons and neutrals, coupled by collision terms.
Results. We confirm that the damping of impulsively generated small-amplitude Alfvén waves slightly affects the temperature of the chromosphere and generates slow plasma flows. In contrast, the Alfvén waves generated by large-amplitude pulses increase the chromospheric plasma temperature more significantly and result in faster plasma outflows. The maximum heating occurs when the pulse is launched from the central photosphere, and the magnitude of the related plasma flows grows with the amplitude of the pulse.
Conclusions. Large-amplitude two-fluid Alfvén waves can contribute significantly to the heating of the solar chromosphere and to the generation of plasma outflows.
Processing of propane-butane fraction on zeolite-containing catalysts
Authors: Tuktin B.T. , Temirova A.M. , Omarova A.A. 
Published: July 2021

Abstarct.
Processing of propane-butane and propane-propylene fractions in light hydrocarbons on the zeolite catalysts modified by zinc, manganese, cobalt, lanthanum was studied. It was shown that the degree of conversion on the Zn-La-Co-ZSM-AI2O3 catalyst increases from 40.2 to 99.0% as the temperature increasesfrom450to600 °C. The maximum yield of aromatic hydrocarbons was 31.4%. As the temperature increases from 450 to 600С, the cracking of hydrocarbons intensifies resulting in the formation of methane and ethane. New generation catalysts based on zeolites have the prospect of being used in technologies for processing various types of hydrocarbon raw materials. The activity of catalysts in the processing of light hydrocarbons depends on the structure and state of the active centers. The physicochemical characteristics of the developed catalysts have been studied. One of the possible ways to control the catalytic properties is to introduce a variable valence catalyst as modifiers into the composition.
Circulating Rotavirus Genotypes among Children Younger than 5 Years with Acute Gastroenteritis in Zaria, Northwestern Nigeria
Authors: Giwa Fatima Jummai , Garba Maria , Mukhtar Abdulaziz , Idris Mukhtar , Lartey Belinda , Damanka Susan , Samaila Modupeola , Muktar Hassan , Olayinka Adebola , Armah George 
Published: July 2021

Abstract
Objective This study aimed to determine the circulating rotavirus genotypes among children 0 to 59 months with acute gastroenteritis in Zaria, Northwestern Nigeria.
Methods A cross-sectional hospital-based study was performed from November 2015 to April 2017 on 415 stool samples of children 0 to 59 months with acute gastroenteritis presenting at the pediatric clinics in five selected health care facilities in Zaria, Northwestern Nigeria. The stool samples were tested for group A rotavirus antigen by enzyme-linked immunosorbent assay (ELISA) using the ProSpecT™ Rotavirus Microplate Assay (Thermo Scientific Oxoid, United Kingdom). Rotavirus-positive strains were further characterized using seminested multiplex reverse transcriptase polymerase chain reaction.
Results Of the 415 diarrheal stool samples collected from children with acute gastroenteritis, 12.3% (n = 51) tested positive by ELISA. Five rotavirus G genotypes (G1, G2, G3, G9, and G12) and three P genotypes (P[4], P[6], and P[8]) were detected. Eight genotype combinations were detected with G1P[8], G12P[8], and G3P[6] being the most prevalent (9.8% each) followed by G1P[6], G2P[4], and G9P[8] (5.9% each). G/P mix types representing 25.5% (n = 13) of strains were detected during the study period.
Conclusion This study found a high diversity of rotavirus strains with emerging unusual rotavirus genotypes and a concurrent high proportion of mixed infections. This increased antigenic diversity of rotavirus strains may impact on vaccine effectiveness and rotavirus epidemiology and highlights the importance of continuous surveillance.
Management and Outcomes of Isolated Distal Deep Vein Thromboses: A Questionable Trend toward Long-Lasting Anticoagulation Treatment. Results from the START-Register
Authors: Palareti Gualtiero , Legnani Cristina , Antonucci Emilia , Testa Sophie , Mastroiacovo Daniela , Cosmi Benilde , Poli Daniela , Bucherini Eugenio , Dentali Francesco , Fontanella Andrea , Mumoli Nicola , Imberti Davide , Falanga Anna , Ageno Walter , Pomero Fulvio 
Published: July 2021

Abstract
Background Isolated distal deep vein thromboses (IDDVT) are frequently diagnosed; however, their natural history and real risk of complications are still uncertain. Though treatment is still not well standardized, international guidelines recommend no more than 3 months of anticoagulation therapy. We investigated how Italian clinicians treat IDDVT patients in their real life in our country.
Methods Baseline characteristics and clinical history of the patients enrolled in the prospective, observational, multicenter START-Register for a first IDDVT or proximal DVT (PDVT) were analyzed.
Results Overall, 412 IDDVT patients were significantly younger, with better renal function, and more frequent major transient risk factors, when compared with 1,173 PDVT patients. The anticoagulation duration was >180 days in 52.7% of IDDVT patients (70.7% in PDVT). During treatment, bleeding occurred in 5.6 and 2.8% patient-years in IDDVT and PDVT, respectively (p = 0082). Bleeding was more frequent in IDDVT than PDVT patients treated with warfarin (6.8 vs. 3.2 patient-years, p = 0.0228, respectively). Thrombotic complications occurred in 1.1 and 2.4% patient-years in IDDVT and PDVT patients, respectively. Analyzing together the two groups, 66.1% of bleeds and 86.1% thrombotic complications occurred after 90 days anticoagulation treatment.
Conclusion The large majority of IDDVT patients received anticoagulation for more than 3 months. Most bleeding and thrombotic complications occurred after the first 90 days of anticoagulation therapy. These results indicate that an extended anticoagulation beyond 90 days in IDDVT patients is associated with increased risk of complications. Whether an extended treatment may lower recurrences after anticoagulation withdrawal should be assessed by specifically designed studies.
Comparison with Navigation of a Novel Three-Step Technique for Improving Accuracy of the Distal Femoral Resection during Conventional TKA: A Case–Control Study
Authors: Mullaji Arun B. , Khalifa Ahmed A. , Shetty Gautam , Thakur Harshad 
Published: July 2021

AbstractCorrect placement of the femoral component in the coronal plane during primary total knee arthroplasty (TKA) is related to long-term survival. The aim of this radiographic study was to determine the accuracy of a novel three-step technique for improving the accuracy of the distal femoral cut during conventional technique and compare it with computer navigation during TKA. A total of 458 TKAs were retrospectively analyzed (178 conventional TKAs with the novel technique and 280 navigated TKAs) for postoperative femoral component coronal alignment and compared between the two groups. Mean femoral component coronal alignment was not significantly different (p = 0.314) between the two groups. There was no significant difference in the mean femoral component coronal alignment between varus and valgus knees. The number of outliers (90 ± 3 degrees) for femoral component coronal alignment was not significantly different between the two groups when assessed separately for varus and valgus deformities. The mean value of femoral component alignment using the conventional technique in knees with varus deformity <10 degrees was 88.8 degrees, in knees with varus deformity 10 to 20 degrees was 89.4 degrees, and in those with varus deformity >20 degrees was 90.2 degrees. Femoral component alignment in knees with varus <10 degrees was significantly different from those >20 degrees (p = 0.006); there was no significant difference between knees with varus <10 degrees and those with 10 to 20 degrees varus (p = 0.251), nor between 10 and 20 degrees varus knees and those with varus >20 degrees (p = 0.116). Using the novel three-step technique during conventional TKA to perform the distal femoral cut can help achieve femoral component coronal alignment comparable to the navigation technique.
Radioembolization for Hepatocellular Carcinoma
Authors: Gunduz Seyda , Saini Gia , Segaran Nicole , Naidu Sailen , Patel Indravadan , Alzubaidi Sadeer , Oklu Rahmi 
Published: July 2021

AbstractHepatocellular carcinoma (HCC) is the fastest-growing cancer worldwide, causing significant morbidity and mortality. Surgical resection, ablation, or transplantation is the best treatment option for patients with HCC. However, only about one-fifth of patients are suitable for such primary curative treatments due to underlying liver disease or rapid extension of the tumor. Image-guided locoregional therapies may prove an important alternative in this scenario, particularly transarterial radioembolization (TARE) with yttrium-90 (Y-90). Based on many studies, TARE can be considered a curative treatment option for patients with early-stage HCC, a bridge to transplantation, and a method for downstaging tumors to give patients with unresectable HCC a chance to potentially receive a curative treatment. TARE can be also combined with other treatment modalities to provide a better quality of life in patients when compared with systemic therapy in patients with unresectable HCC. Here, we discuss the use of TARE in the approach to HCC patients who are in early, intermediate, or advanced stages.
Second language learners’ engagement with written feedback
Authors: Liu Kailin , Storch Neomy 
Published: July 2021

Abstract
Studies on feedback given to second language (L2) learners have focused primarily on learners’ response to feedback on language. This study explores how L2 learners in one university EAP class respond to teacher written feedback on all aspects of writing and the factors that may affect their response. Using data from student initial and revised texts, the study first looks at nine learners’ uptake of feedback. Then, adopting a case study approach and using data from retrospective interviews, the study examines how three learners engage with feedback on different dimensions of their writing. Findings show that learners took up almost all feedback suggestions regardless of form or focus. Yet, learners’ engagement with the feedback differed. Using activity theory (AT), we explain the learners’ engagement with the feedback received by reference to the interaction of context and individual-related factors. Our findings highlight the complexity of learner behavior in response to feedback.
Exploring the Case The Heritage of a Historic Farmhouse in Rural Catalonia
Authors: Louis Oriane , Pi Marta Valls I , Rajerinera Samuel , Sanjivy Agnès , Zhu Chuhong 
Published: July 2021

Introduction
An interesting aspect of the L’Avenc de Tavertet Case Study is the restoration of this ancient building to turn it into a centre for tourism. This Exploring the Case is written for researchers and students in the specifics of such a process and in the challenges that have to be overcome.
Particle charge distributions in the effluent of a flow-through atmospheric pressure low temperature plasma
Authors: Husmann Eric , Thimsen Elijah , Chen Xiaoshuang 
Published: July 2021

Abstract
Atmospheric pressure low-temperature plasmas are often utilized to perform particle synthesis, treatment, and removal. It is well-known that dust particles are highly negatively charged in these plasmas; however, little is known about dust particle charging behavior as particles leave the plasma volume and pass through the spatial afterglow region. In this work, monodisperse particles of various sizes and work functions were introduced into an atmospheric pressure radiofrequency capacitively coupled flow-through plasma. Dust particle electrical mobility distributions downstream of the flow-through plasma were measured utilizing a differential mobility analyzer in conjunction with a condensation particle counter at various gas flow velocities. Charge distributions were determined from the measured electrical mobility distributions. Experiments confirm that particles become less negatively charged, and even net-positively charged after leaving the plasma volume, with a distribution that follows a shifted Boltzmann charge distribution. Additionally, particle charge in the effluent of the flow-through plasma is negligibly dependent on work function but highly size and flow velocity dependent. Larger particles were shown to have a higher magnitude of charge under all studied conditions; however, particle polarity was switchable by varying gas flow velocity. The charging dynamics were simulated utilizing a constant number Monte Carlo model that accounts for electron temperature decay and the transition from ambipolar to free diffusion of electrons and ions in the spatial afterglow. Simulation results also suggest that, at the same flow velocity, larger particles obtain a greater magnitude of charge, negative or positive. The decrease in electron mobility and the difference between ion and electron convective loss rates create an ion-rich region in the plasma effluent that promotes ion–particle collisions and drives particle charge removal and even reversal of polarity. Larger particles more favorably collide with energetic species in these environments, which results in higher charge states.
Time-domain optics for atomic quantum matter
Authors: Kanthak Simon , Gebbe Martina , Gersemann Matthias , Abend Sven , Rasel Ernst M , Krutzik Markus 
Published: July 2021

Abstract
We investigate time-domain optics for atomic quantum matter. Within a matter-wave analog of the thin-lens formalism, we study optical lenses of different shapes and refractive powers to precisely control the dispersion of Bose–Einstein condensates. Anharmonicities of the lensing potential are incorporated in the formalism with a decomposition of the center-of-mass motion and expansion of the atoms, allowing to probe the lensing potential with micrometer resolution. By arranging two lenses in time formed by the potentials of an optical dipole trap and an atom-chip trap, we realize a magneto-optical matter-wave telescope. We employ this hybrid telescope to manipulate the expansion and aspect ratio of the ensembles. The experimental results are compared to numerical simulations that involve Gaussian shaped potentials to accommodate lens shapes beyond the harmonic approximation.