bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphism of ABO*O alleles and its clinical significance
Authors: Golovkina L. L. , Kalandarov R. S. , Pshenichnikova O. S. , Surin V. L. , Stremoukhova A. G. , Pushkina T. D. , Atroshchenko G. V. , Kalmykova O. S. , Khasigova B. B. 
Published: November 2021

Background. 62 ABO*O alleles of the ABO system are known. Some ABO*O alleles may be accompanied by the presence of residual A-glycosyltransferase activity in people of group O, which may lead to errors in determining the blood group. This confirms the important clinical significance of the ABO*O allele polymorphism. Knowledge of ABO*O gene polymorphisms and their prevalence contributes to the prevention of errors in determining the blood group of the ABO system.Objective: to study allele variants of the ABO*O gene in Russians.Materials and methods. The blood samples of 14,000 people were examined. The blood group was determined using anti-A, anti-Aweak, anti-B, lectin (anti-A1) and gel cards, as well as by cross-sectional method using standard red blood cells of O, A, and B groups. In one patient, the method of adsorption-elution with cold elution was used to identify a weak variant of antigen A, and the method of thermal elution was used to eliminate antigen- blocking plasma factors. Molecular determination of ABO*O alleles was performed in 130 individuals by polymerase chain reaction with sequence- specific primers and Sanger direct sequencing.Results. 13 allelic variants of the ABO*O gene were identified (10 with a typical deletion of c.261delG / N and 3 nondeletional alleles with polymorphism c.802G>A). Deletion alleles of ABO*O.01 were found in 92.85 % of the examined patients, nondeletion alleles of АВО*О.02 group – in 7.15 % of cases. The ABO*O.01.01 allele was detected with a frequency of 67.14 %, other deletion alleles – much less frequently: ABO*O.01.02 and ABO*O.01.11 – 5.71 %, ABO*O.01.26 – 5.00 %, ABO*O.01.12 – 4.30 %, ABO*O.01.13 and ABO*O.01.44 – 1.43 %, ABO*O.01.05, ABO*O.01.46, ABO*O.01.68 – 0.71 % each. Non-deletional alleles were found with the following frequencies: ABO*O.02.01 – 4.3 %, ABO*O.02.03 allele – 2.14 %, ABO*O.02.02 – 0.71 %. All individuals with the O group with the nondeletional allele had the Oαβ group, except for one patient (with the ABO*O.01.02 O.02.02 genotype), who had the Oβ group.Conclusion. For the first time, the immunogenetic characteristics of Russians are given according to ABO*O genes. Erythrocyte genomics helps to resolve the ambiguity of serological methods results and allows understanding mechanisms of different phenotypes formation. For the correct definition of natural isohemagglutinins and weak antigens variants should be used at least two different serological methods.
Key issues of patient safety during anticancer drug treatment in a day hospital and outpatient setting
Authors: Fedenko A. A. , Kolomeytseva A. A. , Artemova V. O. 
Published: November 2021

Background. In the context of the ongoing COVID-19 pandemic, the vector of healthcare development is aimed at minimizing contacts among citizens, which is especially important for cancer patients, given the immunosuppression caused by cytostatics.The objective of the review is to present the development prospects of hospital-substituting technologies for drug antitumor treatment. Two main components are considered that allow effective and safe infusion of anticancer drugs in a day hospital: central venous access devices and infusion pumps, various types of these devices, their safety and experience of use today are described.Materials and methods. We searched for available literature published in PubMed, Medline, eLIBRARY, Cochrane Library, CyberLeninka, Global.health, etc. 42 sources were found and analyzed, published from 2002 to 2021.Results. Outpatient anticancer drug treatment is a real alternative to hospital stay, based on many years of world experience. The qualifications level of medical personnel involved in the treatment process should allow early monitoring of various adverse events development. With the ongoing COVID-19 pandemic, it is important to ensure the continuity of the treatment process while minimizing risks to the patient.Conclusion. With a careful approach and adequate infrastructure availability, drug treatment in a day hospital can reduce the burden on round-the-clock stay hospital and positively affect the patients’ quality of life and their compliance with treatment.
PENGEMBANGAN MODEL PEMBELAJARAN GERAK DASAR BOLA VOLI UNTUK SISWA SDN 16 SUNGAI RAYA KABUPATEN KUBU RAYA
Authors: Supriatna Eka 
Published: November 2021

Tujuan dari peneltian ini untuk menemukan model-model pembelajaran bolavoli dalam bentuk modul yang sesuai dengan karakteristik siswa sekolah tingkat dasar (SD). Bentuk Desain Penelitian yang digunakan adalah pendekatan pengembangan Research And Development (R&D) yang dikemukakan oleh Borg dan Gall. Instrumen yang digunakan dalam penelitian ini adalah kuesioner observasi penilaian dari ahli materi bolavoli, kuesioner observasi penilaian ahli media dan kuesioner keefektifkan siswa. Hasil penelitian pengembangan ini adalah sebuah modul pembelajaran gerak dasar bolavoli untuk siswa SDN 16 Sungai Raya Kabupaten KubuRaya. Berdasarkan hasil penilaian ahli materi bolavoli sebesar 84,37% dan ahli media sebesar 88,33% serta nilai uji keefektifan pada kelompok sebesar 87,34 %. Kesimpulan produk sangat baik, sehingga layak digunakan untuk pembelajaran pendidikan jasmani pada siswa sekolah tingkat dasar di SDN 16 Sungai Raya Kabupaten Kubu Raya.
ONLINE ASSESSMENT OF COGNITIVE ASPECTS IN HIGHER EDUCATION
Authors: Fitriady Gema , Sugiyanto Sugiyanto , Sugiarto Tatok 
Published: November 2021

The use of online assessment s has been widely used in various fields including universities. Research to find the validity of online assessment s has been conducted and the results are high but the opinions of people who are assessed on the application of online assessment s have not been carried out. The purpose of this study was to determine the opinion of the person being assessed after conducting an online assessment . 150 students were selected to be respondents consisting of 126 male and 24 female who were taken by the sampling technique, namely the total sampling. The application of online assessment s in universities is very suitable. There are several advantages to implementing online assessment s, including 1) it is preferred by students so that students will be motivated to conduct assessment s; 2) high accessibility and flexibility; 3) rapid feedback. Therefore, the use of online assessment s in higher education can be done without reducing the quality of the assessment .
Educación literaria y promoción lectora apoyadas en entornos literarios inmersivos con realidad aumentada
Authors: Neira-Piñeiro María del Rosario , Del-Moral-Pérez Esther 
Published: November 2021

Los entornos literarios inmersivos (ELI) son escenarios educativos diseñados a partir de objetos físicos que recrean obras literarias infantiles, proporcionando información digital superpuesta con realidad aumentada (RA) y favoreciendo un aprendizaje inmersivo. Con esta investigación cualitativa -centrada en el estudio de casos- nos proponemos: 1) analizar 25 ELI elaborados por futuros maestros, para promover la educación lectora y literaria en infantil, atendiendo a dos dimensiones: a) tecnológico-interactiva, describiendo el soporte y recursos RA utilizados, y b) didáctico-literaria, identificando y cuantificando la tipología de textos y actividades. 2) Determinar el nivel de satisfacción de los futuros maestros al concluir la experiencia. Los resultados revelan que los ELI -basados en textos literarios- recrean universos ficcionales apoyados en recursos RA, dando vida a los personajes e incluyendo actividades con y sin RA. El 64% de los ELI utiliza maquetas, el 24% lapbooks y el resto prima otros soportes, incluyendo láminas-marcadores, vídeos, animaciones de personajes, juegos online, activadores RA, códigos QR, etc. La experiencia innovadora resultó muy satisfactoria para los futuros docentes, quienes aprovecharon las oportunidades de la RA para diseñar actividades de educación literaria y promover un aprendizaje lúdico y multisensorial.
Creación poética en nuevos contextos
Authors: Campos-F.-Fígares Mar 
Published: November 2021

En el presente trabajo nos aproximamos a las prácticas literarias con las que los jóvenes lectores tienen una mayor vinculación en la actualidad. La creación en las redes y la lectura a través de las pantallas han configurado un nuevo modelo de comunicación entre autores y receptores que necesitamos analizar para tener puntos de partida sobre los que edificar la educación literaria. El objetivo principal del trabajo es revisar las modificaciones surgidas a partir de las TIC en la creación y recepción de la poesía, por medio de la descripción de algunos de los contenidos literarios a los que los jóvenes acceden desde los dispositivos digitales. Así, acotaremos conceptualmente dos grandes tipologías de lectura que requieren de habilidades muy diferentes, y ciñéndonos al ámbito de la poesía, uno de los géneros con gran auge entre jóvenes y adolescentes. Se concluye que se precisa una formación específica de mediadores en lectura y escritura no solo para visibilizar todos estos ámbitos, sino también para emplearlos en favor de la educación literaria.
IMPACT OF PAKISTAN TELEVISION’S INFOTAINMENT PROGRAM BAZM-E-TARIQ AZIZ ON YOUTH EDUCATION
Authors: Chaudhary Muhammad Umair , Ghani Abdul , Usman Sobia , Farooq Usman 
Published: November 2021

Purpose of the study: The present study analyses the impact of PTV infotainment and the educative program Bazm-e-Tariq Aziz (Neelam Gher) on moulding the behaviours of youth in Pakistan. The purpose and, major focus of the study is to measure and analyses the effect of the Television program on youth education in Pakistan.
Methodology: Quantitative method was used in this study. In this regard, survey was conducted from the population having diverse demographics viz: gender, age group, and education etc.
Main Findings: The findings of the study depict that the PTV program Bazm-e-Tariq Aziz (Neelam Gher) has imparted knowledge, awareness, and education to the young population of Pakistan.
Application of this study: The study may be applied to examine the learning behaviour of youth through infotainment programs aired on Television.
Novelty / originality of this study: Electronic media plays a significant role in the dissemination of knowledge and education. Since the inception of Pakistan Television (PTV) in the country, it has been widely watched by the public of all age groups particularly the youth of the country. PTV has aired many informative and infotainment programs but the program Bazm-e-Tariq Aziz (Neelam Gher) has played a special role in educating the masses through its diverse style and programming.
ANALISIS PERMASALAHAN GURU PAUD PADA PEMBELAJARAN DARING (DALAM JARINGAN) DI MASA PANDEMI COVID-19
Authors: Novitasari Yesi , Reswita Reswita , Efastri Sean Marta 
Published: November 2021

Penelitian ini bertujuan untuk mendeskripsikan tentang permasalahan-permasalahan yang dihadapi guru PAUD dalam melaksanakan pembelajaran dalam jaringan (daring) pada masa pandemi covid-19 khususnya di Kecamatan Tenayan Raya. Jenis penelitian ini merupakan penelitian deskriptif. Populasi pada penelitian ini berjumlah 37 guru. Teknik penggumpulan data pada penelitian ini menggunakan kuisioner, sedangkan teknik analisis data menggunakan analisis deskriptif kuantitatif. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat permasalahan dalam proses pembelajaran daring pada masa pandemi Covid-19 di Kecamatan Tenayan Raya. Untuk indikator pengorganisasian materi, sikap positif anak, dan keluwesan pembelajaran berada dalam kategori sedikit. Sedangkan indikator komunikasi (daring), penguasaan dan antusiasme dan hasil belajar dikategorikan banyak.
REPRESENTASI PERPUSTAKAAN DAN PUSTAKAWAN DALAM FILM SERIAL ANIMASI UPIN IPIN “AKU SEBUAH BUKU: Analisis Semiotik pada Serial Animasi Upin Ipin “Aku Sebuah Buku”
Authors: Juvitasari Prisca Budi 
Published: November 2021

AbstractFilm is a media representation that can describe something, including a library. Assessing library representation media such as film would be significant to know libraries concept in communities. This study describes the representation of libraries and librarians in the animated series Upin and Ipin: I’m a Book. This study uses descriptive qualitative research using semiotic analysis using the Charles Sanders Peirce model, which aims to describe the representation of libraries and librarians in films with the principles of reality and representation. The conclusion of this study explains that the library is described as a crowded place with various types of visitors. While the librarian is described as being angry when he sees books placed out of place, but still friendly when serving visitors using conventional systems. Keywords: Library, representation, librarian, animated series AbstrakFilm merupakan suatu media representasi untuk menggambarkan sesuatu termasuk perpustakaan. Representasi perpustakaan dalam media seperti film menjadi penting untuk dapat mengetahui konsep perpustakaan yang berada dalam pikiran masyarakat. Penelitian ini menjelaskan tentang representasi perpustakaan dan pustakawan dalam film serial animasi Upin dan Ipin “Aku Sebuah Buku”. Teknik penelitian yang digunakan yaitu kualitatif deskriptif dengan menggunakan analisis semiotik teori Charles Sanders Peirce yang bertujuan untuk mendeskripsikan representasi perpustakaan dan pustakawan yang ada dalam film dengan menggunakan prinsip realitas dan representasi. Kesimpulan dari penelitian ini adalah perpustakaan digambarkan sebagai tempat yang ramai dengan berbagai macam jenis pengunjung. Sedangkan pustakawan digambarkan sebagai seorang laki-laki yang memiliki sifat pemarah dan emosional ketika melihat buku diletakkan tidak pada tempatnya, namun tetap bersikap ramah saat melayani pengunjung dengan menggunakan sistem yang masih konvensional. Kata Kunci: Perpustakaan, representasi, pustakawan, serial animasi
Evaluasi Pelaksanaan Pembelajaran Online Selama Pandemi Covid-19 Berdasarkan Perspektif Dosen dan Mahasiswa
Authors: Masruroh Masruroh , Nawafilah Nur Qomariyah , Anggraini Erry 
Published: November 2021

Penelitian ini bertujuan mendeskripsikan evaluasi pelaksanaan pembelajaran online secara umum selama pandemi Covid-19 berdasarkan perspektif dosen dan mahasiswa Teknik Informatika Universitas Islam Lamongan. Penelitian ini merupakan penelitian deskriptif kuantitatif. Data dikumpulkan menggunakan kuisioner Google form yang diberikan kepada 165 responden. Evaluasi pelaksanaan pembelajaran meliputi efektivitas pelaksanaan, kemudahan dalam menyampaikan dan menerima materi, platform pembelajaran yang sering digunakan, metode yang paling efektif digunakan, serta kendala yang dialami. Hasil penelitian menunjukkan pembelajaran online sudah berjalan cukup efektif (70%), materi cukup dapat disampaikan dan diterima dengan baik (72%), platform yang paling sering digunakan adalah Google Classroom (85%), metode yang paling efektif melalui tatap muka virtual (53%), dan kendala yang paling sering dialami adalah jaringan yang tidak stabil (48%). Secara umum dapat disimpulkan pelaksanaan pembelajaran online sudah berjalan cukup baik.
Thermochemistry Comic as A Self Learning Resource for Grade 11 Students
Authors: Oktapianti Siska 
Published: November 2021

The purposes of this development research are: (1) to develop a chemistry comic book in thermochemistry chapter, (2) to evaluate quality of the chemistry comic book based on assessment of chemistry teachers and students at senior high school/islamic senior high school .This research uses procedural model that is a descriptive model. The procedural model contains many steps that we have to follow to launch a product. The development of this chemistry comic book is guided by thesis supervisors, media expert and peer reviewers. The instrument used to evaluate the quality of this chemistry comic book is a set of quality which has some aspects and criteria. The evaluation result is in qualitative data and then the result is tabulated and analyzed by the ideal evaluation criteria category guide to measure the quality of a chemistry comic book. This comic includes 5 sub topics, i.e heat, enthalpy and the change, calculating the change in enthalpy, calorimeter, and fuel. Based on the evaluation converted by 3 chemistry teachers and 6 students, the chemistry comic book developed in this research has a good quality. Based on teachers’ assessment, the chemistry comic book has a good quality, going the score of 146.33 from the maximum point 190 and ideal percentage 77.02%. Meanwhile, based on students’ assessment, it has a good quality, going the score of 106.33 from the maximum point 135 and ideal percentage 78.76%. There it can be used as the guideline of the additional study sources.
Design and Trial of Chemistry Pocketbook Contained Science Generic Skills
Authors: Susanti Susi , Ritonga Pangoloan Soleman 
Published: November 2021

This research aimed at developing a pocket book containing science generiC skills on Reaction Rate lesson and knowing validity level, practicality level, and student response to the developed pocket book. It was Research and Development (R&D) with Borg and Gall model. The subjects of this research were 10 the twelfth-grade students of Natural Science 3 at Islamic Senior High School of Darul Hikmah Pekanbaru. The object was the pocket book containing science generik skills on Reaction Rate lesson. Validity test questionnaire, practicality test questionnaire, student response test questionnaire, interview, and documentation were the techniques of collecting the data. Analyzing the data was done by using qualitative and quantitative descriptive analysis techniques. The research findings showed that the validity level of the chemistry pocket book was 76.3% (valid), the practicality level was 81.2% (very practical), and the percentage of student response to the pocket book was 84.2% (very good). It could be concluded that the chemistry pocket book containing science generik skills on Reaction Rate lesson could be tested wider.
The prevalence rate of hypopituitarism in patients with pituitary macroadenomas with various hormonal activities
Authors: Krivosheeva Yu. G. , Ilovayskaya I. A. 
Published: November 2021

Rationale: According to the recent epidemiological studies, prevalence of pituitary tumors amounts to 1 per 865 to 2688 adults. The prevalence rates of hypopituitarism in pituitary macroadenomas are highly variable and comprise 37% to 85% among newly diagnosed non-functioning pituitary adenomas (NFPA). There is virtually no data on the prevalence of hypopituitarism in the cohort of newly diagnosed macroadenomas secreting prolactin and somatotropic hormone.Aim: To assess the prevalence of hypopituitarism in patients with pituitary macroadenomas with various hormonal activities and to identify its potential risk factors.Materials and methods: We analyzed data from 293 patients with pituitary macroadenomas with various hormonal activities: NFPA (n = 121), prolactinomas (n = 59), and somatotropinomas (n = 113). The patients had been examined before any treatment was commenced.Results: The prevalence rate of hypopituitarism was 59/121 (39.9%) among the patients with NFPA, 18/59 (27.3%) among those with prolactinomas, and 19/113 (14%) among those with somatotropinomas (р < 0.001). The symptoms of chiasmal compression and chiasmal syndrome were significantly more prevalent in the patients with hypopituitarism, than in those without it in all subgroups. The relative risk of hypopituitarism in the patients with chiasmal compression was 2.10 for NFPA (95% confidence interval (CI) 1.50-2.95, р=0.003), 1.667 for prolactinomas (95% CI 1.292.18, р = 0.005), and 1.45 for somatotropinomas (95% CI 1.56-2.48, р = 0.001). The relative risk of hypopituitarism in the patients with chiasmal syndrome was 1.66 for NFPA (95% CI 1.26-2.18, р=0.009), 2.08 for prolactinomas (95% CI 1.602.69, р = 0.001), and 1.97 for somatotropinomas (95% CI 1.56-2.48, р = 0.005). The NFPA subgroup had the highest rate of hypothyroidism (36/59, 61.0%), whereas the prolactinoma subgroup had the highest rate of secondary hypogonadism (34/59, 57.6%); however, hypogonadism is one of the manifestations of persistent pathological hyperprolactinemia typical for prolactinomas. In the somatotropinoma subgroup, secondary hypothyroidism was found in 11/19 (57.9%) of the patients. Conclusion: Identification of hypopituitarism before any treatment depended on the type of hormonal activity of a pituitary tumor and was most frequent in NFPA. The risk factors for hypopituitarism were chiasmal compression, chiasmal syndrome, vertical diameter of the pituitary tumor, and its volume. Secondary adrenal insufficiency, being the most hazardous component of hypopituitarism, manifested most rarely.
A comparison of online video conference platforms: Their contributions to education during COVID-19 pandemic
Authors: Cavus Nadire , Sekyere-Asiedu Daniel 
Published: November 2021

COVID-19 has brought dramatic changes into the ways our day-to-day activities are carried out in recent times. Education was also affected. Online education was adopted as means to administer teaching and learning. There are numerous online video conference platforms currently available to assist in education. Nevertheless, with these platforms are various features with their inherent advantages and disadvantages. Choosing the suitable ones to meet the need of users could be a daunting task. This study utilized a comparative research method to compare features; maximum participants meeting recording duration, security, chat/screen sharing, meeting duration, archive meeting, trial versions, account creation to use and mobility, of seven online video conference platforms; Google Meet, Microsoft Teams, GoToMeeting, Cisco WebEx Meetings, Zoom Meetings, ClickMeetings and BigBlueButton. This study would aid learners, instructors and educational institutions to choose from the numerus platforms, to suit the specific needs and usage during this pandemic period and beyond.

Keywords: Online video conference platform, online classrooms, online video conference platform, e-learning, Covid-19