bluuebunny/crossref_metadata_2025_split huggingface dataset:
A generic outcome assessment of mobility capacity in neurorehabilitation: measurement properties of the de Morton Mobility Index
Authors: Braun Tobias , Marks Detlef , Thiel Christian , Grüneberg Christian 
Published: March 2021

Abstract
Background: Mobility capacity is a key outcome domain in neurorehabilitation. The de Morton Mobility Index (DEMMI), an established and generic outcome assessment of mobility in older patients, is promising for use in neurorehabilitation.Objective: To examine the measurement properties of the DEMMI in rehabilitation inpatients with neurological conditions.Methods: Cross-sectional study including a mixed sample of adult inpatients in a neurorehabilitation hospital. Structural validity, unidimensionality and measurement invariance (Rasch analysis), construct validity, internal consistency reliability, and inter-rater reliability of the DEMMI (scale range: 0–100 points) were established. The minimal detectable change, the 95% limits of agreement, and possible floor and ceiling effects were calculated to indicate interpretability. Results: We analyzed validity (n = 348) and reliability (n = 133) in two samples. In both samples, the majority of participants had a sub-acute stroke or Parkinson’s disease. Rasch analysis indicated unidimensionality with an overall fit to the model (chi-square = 59.4, P = 0.074). There was no relevant measurement invariance by disease group. All 11 hypotheses on construct validity were confirmed. Internal consistency reliability (Cronbach’s alpha = 0.94) and inter-rater reliability (intraclass correlation coefficient = 0.94; 95% confidence interval: 0.91–0.95) were sufficient. The minimal detectable change with 90% confidence was 15.0 points and the limits of agreement were 39%. No floor or ceiling effects were observed. Conclusions: Results indicate sufficient measurement properties of the DEMMI in rehabilitation inpatients with neurological conditions. The DEMMI can be used as a generic outcome assessment of mobility capacity in neurorehabilitation.Trial registration: German Clinical Trials Register (DRKS00004681). Registered May 6, 2013.
A Social Media–Promoted Educational Community of Joint Replacement Patients Using the WeChat App: Survey Study
Authors: Zhang Xianzuo , Chen Xiaoxuan , Kourkoumelis Nikolaos , Gao Ran , Li Guoyuan , Zhu Chen 
Published: March 2021

Background
Much effort has been made to optimize the results of total hip arthroplasty and total knee arthroplasty. With the rapid growth of social media use, mobile apps, such as WeChat, have been considered for improving outcomes and patient satisfaction after total hip arthroplasty and total knee arthroplasty.

Objective
We aimed to evaluate the effectiveness of a WeChat-based community as an intervention for overall patient satisfaction.

Methods
The study was conducted among discharged in-hospital patients who received hip or knee procedures in the First Affiliated Hospital of the University of Science and Technology of China from April 2019 to January 2020. An educational online social community was constructed with the WeChat app. Participants willing to join the community were enrolled in a WeChat group and received 3 months of intervention and follow-up. Those who were not willing to use the account were included in a control group and received routine publicity via telephone, mail, and brochures. The Danish Health and Medicine Authority patient satisfaction questionnaire was used to score perioperative patient education and overall satisfaction. The contents in the group chat were analyzed using natural language processing tools.

Results
A total of 3428 patients were enrolled in the study, including 2292 in the WeChat group and 1236 in the control group. Participants in the WeChat group had higher overall satisfaction scores than those in the control group (mean 8.48, SD 1.12 vs mean 6.66, SD 1.80, P<.001). The difference between the two groups was significant for primary surgery based on subgroup stratification. To control confounding factors and explore the effects of WeChat participation as a mediating variable between perioperative patient education and overall satisfaction, hierarchical regression was utilized. An interpatient interaction model was found in the community group chat, and it contributed to overall satisfaction. Patients in the group with more interpatient interactions were more likely to have better overall satisfaction.

Conclusions
The social media–promoted educational community using WeChat was effective among joint replacement patients. Provision of more perioperative education is associated with more active patient participation in the community and therefore more patient satisfaction in terms of the overall joint procedure. Community group chat could facilitate interactions among patients and contribute to overall satisfaction.
SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study
Authors: Ciccone Emily J , Zivich Paul N , Lodge Evans K , Zhu Deanna , Law Elle , Miller Elyse , Taylor Jasmine L , Chung Suemin , Xu Jason , Volfovsky Alexander , Beatty Cherese , Abernathy Haley , King Elise , Garrett Haley E , Markmann Alena J , Rebuli Meghan E , Sellers Subhashini , Weber David J , Reyes Raquel , Alavian Naseem , Juliano Jonathan J , Boyce Ross M , Aiello Allison E 
Published: March 2021

Background
Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversion in this population is needed.

Objective
The primary objectives of this study are to (1) determine the incidence of, and risk factors for, SARS-CoV-2 infection among HCP at a tertiary care medical center and (2) actively monitor PPE use, interactions between study participants via electronic sensors, secondary cases in households, and participant mental health and well-being.

Methods
To achieve these objectives, we designed a prospective, observational study of SARS-CoV-2 infection among HCP and their household contacts at an academic tertiary care medical center in North Carolina, USA. Enrolled HCP completed frequent surveys on symptoms and work activities and provided serum and nasal samples for SARS-CoV-2 testing every 2 weeks. Additionally, interactions between participants and their movement within the clinical environment were captured with a smartphone app and Bluetooth sensors. Finally, a subset of participants’ households was randomly selected every 2 weeks for further investigation, and enrolled households provided serum and nasal samples via at-home collection kits.

Results
As of December 31, 2020, 211 HCP and 53 household participants have been enrolled. Recruitment and follow-up are ongoing and expected to continue through September 2021.

Conclusions
Much remains to be learned regarding the risk of SARS-CoV-2 infection among HCP and their household contacts. Through the use of a multifaceted prospective study design and a well-characterized cohort, we will collect critical information regarding SARS-CoV-2 transmission risks in the health care setting and its linkage to the community.

International Registered Report Identifier (IRRID)
DERR1-10.2196/25410
Healthfulness Assessment of Recipes Shared on Pinterest: Natural Language Processing and Content Analysis
Authors: Cheng Xiaolu , Lin Shuo-Yu , Wang Kevin , Hong Y Alicia , Zhao Xiaoquan , Gress Dustin , Wojtusiak Janusz , Cheskin Lawrence J , Xue Hong 
Published: March 2021

BackgroundAlthough Pinterest has become a popular platform for distributing influential information that shapes users’ behaviors, the role of recipes pinned on Pinterest in these behaviors is not well understood.ObjectiveThis study aims to explore the patterns of food ingredients and the nutritional content of recipes posted on Pinterest and to examine the factors associated with recipes that engage more users.MethodsData were collected from Pinterest between June 28 and July 12, 2020 (207 recipes and 2818 comments). All samples were collected via 2 new user accounts with no search history. A codebook was developed with a raw agreement rate of 0.97 across all variables. Content analysis and natural language processing sentiment analysis techniques were employed.ResultsRecipes using seafood or vegetables as the main ingredient had, on average, fewer calories and less sodium, sugar, and cholesterol than meat- or poultry-based recipes. For recipes using meat as the main ingredient, more than half of the energy was obtained from fat (277/490, 56.6%). Although the most followed pinners tended to post recipes containing more poultry or seafood and less meat, recipes with higher fat content or providing more calories per serving were more popular, having more shared photos or videos and comments. The natural language processing–based sentiment analysis suggested that Pinterest users weighted taste more heavily than complexity (225/2818, 8.0%) and health (84/2828, 2.9%).ConclusionsAlthough popular pinners tended to post recipes with more seafood or poultry or vegetables and less meat, recipes with higher fat and sugar content were more user-engaging, with more photo or video shares and comments. Data on Pinterest behaviors can inform the development and implementation of nutrition health interventions to promote healthy recipe sharing on social media platforms.
Efficacy of Mobile Health in Patients With Low Back Pain: Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Chen Mingrong , Wu Tingting , Lv Meina , Chen Chunmei , Fang Zongwei , Zeng Zhiwei , Qian Jiafen , Jiang Shaojun , Chen Wenjun , Zhang Jinhua 
Published: March 2021

Background
Low back pain is one of the most common health problems and a main cause of disability, which imposes a great burden on patients. Mobile health (mHealth) affects many aspects of people’s lives, and it has progressed rapidly, showing promise as an effective intervention for patients with low back pain. However, the efficacy of mHealth interventions for patients with low back pain remains unclear; thus, further exploration is necessary.

Objective
The purpose of this study was to evaluate the efficacy of mHealth interventions in patients with low back pain compared to usual care.

Methods
This was a systematic review and meta-analysis of randomized controlled trials designed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis) statement standard. We searched for studies published in English before October 2020 in the PubMed, EMBASE, Web of Science, and Cochrane Library databases. Two researchers independently scanned the literature, extracted data, and assessed the methodological quality of the included studies. Bias risks were assessed using the Cochrane Collaboration tool. We used RevMan 5.4 software to perform the meta-analysis.

Results
A total of 9 studies with 792 participants met the inclusion criteria. The simultaneous use of mHealth and usual care showed a better reduction in pain intensity than usual care alone, as measured by the numeric rating scale (mean difference [MD] –0.85, 95% CI –1.29 to –0.40; P<.001), and larger efficacy in reducing disability, as measured by the Rolland-Morris Disability Questionnaire (MD –1.54, 95% CI –2.35 to –0.73; P<.001). Subgroup analyses showed that compared with usual care, mHealth using telephone calls significantly reduced pain intensity (MD –1.12, 95% CI –1.71 to –0.53; P<.001) and disability score (MD –1.68, 95% CI –2.74 to –0.63; P<.001). However, without the use of telephone calls, mHealth had no obvious advantage over usual care in improving pain intensity (MD –0.48, 95% CI –1.16 to 0.20; P=.16) and the disability score (MD –0.41, 95% CI –1.88 to 1.05; P=.58). The group that received a more sensitive feedback intervention showed a significantly reduced disability score (MD –4.30, 95% CI –6.95 to –1.69; P=.001).

Conclusions
The use of simultaneous mHealth and usual care interventions has better efficacy than usual care alone in reducing pain intensity and disability in patients with low back pain. Moreover, the results of subgroup analysis revealed that mHealth using telephone calls might play a positive role in improving pain intensity and disability in patients with low back pain.
VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF CINNARIZINE IN BINARY MIXTURE WITH PARACETAMOL IN BULK AND TABLETS
Authors: AL-GHANI AHMED M , AM THABET ANES 
Published: March 2021

Objectives: The aim of this work was to develop and validate new, simple, accurate, and selective spectrophotometric methods (derivative and derivative ratio spectrophotometric methods) for the determination of these drugs. These methods can be used as analytical tools in routine examination in quality control laboratories.
Methods: The first method was derivative method in which the first derivative method (1D) for determination of PCM and the second derivative method (2D) for determination of CIN. The second method was the first derivative ratio spectrophotometric method (1DD) for determination of CIN and PCM.
Results: In first method, the first derivative spectrum (1D) of PCM where PCM was determined by measuring the amplitude of the valley at 235 nm while CIN showed zero crossing spectrum, and the second derivative spectrum (2D) of CIN where CIN was determined by measuring the amplitude of the peak at 287.5 nm while PCM showed a zero value. In the second method, the first derivative ratio spectrophotometry (1DD) for CIN and PCM determination, where the amplitude at 290 and 291 nm, was selected for the determination of CIN and PCM, respectively.
Conclusions: The developed methods were applied for the determination of the cited drugs in tablets containing binary drug mixture. The methods are simple and precise and can be used for routine analysis of the labeled drugs in combined dosage forms in quality control laboratories.
IN VIVO EFFICACY OF TOPICAL BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) LEAF ETHANOLIC EXTRACT ON TRANSFORMING GROWTH FACTOR-BETA 1 IN INFECTED WOUNDS
Authors: NAWAWI RIZKI ANDINI , KAMALUDDIN MUHAMMAD TOTONG , THEODORUS  
Published: March 2021

Objective: This study’s aim was to assess the efficacy of topical Binahong (Anredera cordifolia (Ten.) Steenis) leaf ethanolic extract administration on serum transforming growth factor-beta 1 (TGF-β1) in infected wounds.
Methods: An experimental study, in vivo, was conducted in the Biotechnology Laboratory and Animal House, Faculty of Medicine, Universitas Sriwijaya, Palembang, from July to September 2020. There were 30 male Wistar rats aged 10–12 weeks with excisional wounds infected with Staphylococcus aureus ATCC 25923. The rats were divided into five groups and received three concentrations of Binahong leaf extracts (2.5%, 5%, and 10%), salve base, and povidone iodine 10% topically twice daily for 14 days. Serum was obtained before treatment and after 14 days of treatment. Wound area and bacterial count were also recorded and analyzed. Data analysis was performed using computer software.
Results: Wound size and bacterial count were significantly decreased in treatment groups receiving topical Binahong leaf ethanolic extract. No significant increase in serum TGF-β1 was observed in all treatment groups.
Conclusion: Topical administration of Binahong leaf ethanolic extract on rats with infected wounds for 14 days did not significantly increase serum TGF-β1.
Modelo para aplicação do direito à educação superior privada no brasil: policontexturalidade em Gunther Teubner
Authors: Andrade Ruy Amaral 
Published: March 2021

Tornou-se cada vez mais frequente a propositura de ações judiciais que tem por objeto o acesso ao
ensino superior privado em Direito de jovens que não cumprem os requisitos necessários apontados
no artigo 44, inciso II, da Lei de Diretrizes e Bases da Educação (Lei 9.304 de 1996), em especial, a
conclusão do ensino médio. O que se propõe no presente trabalho é a análise da aplicação do direito
que rege as relações jurídicas das instituições privadas de ensino superior, aplicação que faz parte
do contexto dessas relações, qual seja, o acesso ao ensino superior privado e a judicialização desse
acesso. Para tanto, será proposta a adoção do modelo teórico apresentado por Gunther Teubner,
que preconiza reconstruir a compreensão da regulamentação jurídica da matéria, a respeito da
convivência entre o Direito Público e o Direito Privado, adotando, como alternativa, o conceito de
policontexturalidade, cunhado pelo filósofo alemão Gotthard Günther. Propõe-se que o Direito
Educacional, em especial no ensino superior, seja visto como sistema autônomo, compatível com o
Direito Privado, de modo que eventual julgamento sobre o mérito da questão esteja de acordo com a
matriz institucional desse sistema.
APRESENTAÇÃO - VOLUME 110, N. 2, DA REVISTA DE DOUTRINA E JURISPRUDÊNCIA - RDJ
Authors: De Santis Sandra 
Published: March 2021

Este volume da Revista de Doutrina e Jurisprudência – RDJ reflete a busca constante da Corte por trilhar o caminho da modernidade e adequar a prestação jurisdicional às novas realidades sociais. Tal como ocorria nas antigas Ágoras, locais de divulgação das contribuições intelectuais da Grécia, a RDJ apresenta aos leitores temas que instigam discussões sobre dignidade da pessoa humana, cidadania, ética, inovações sociais e tecnológicas, defesa do consumidor, sanção contratual e educação.
Por fim, para inovar é que a Revista de Doutrina e Jurisprudência - RDJ foi reformulada. A cada edição esmera-se para trazer artigos fomentadores de discussões jurídicas e acadêmicas, sempre com os olhos voltados para o futuro e o desenvolvimento. Todos os artigos escolhidos abordam uma forma de avanço, seja social, tecnológico ou de pensamento. Resta ao Direito
o desafio de acompanhar tantas inovações.
ОЦІНКА БІОЛОГІЧНОЇ ДІЇ ЕЛЕМЕНТВМІСНИХ ЛІПІДНИХ КОМПЛЕКСІВ З CHLORELLA VULGARIS НА ФУНКЦІОНАЛЬНИЙ СТАН ЗДОРОВИХ ЩУРІВ
Authors: Bodnar O. I. , Kovalska H. B. , Lukashiv O. Ya. , Grubinko V. V. 
Published: March 2021

Chlorella is one of the most promising species of algae, which is widely cultivated for the industrial production of nutraceuticals in the form of tablets or powder. The value of Chlorella is primarily due to the high content of proteins and lipids (51–58 % and 20–23 % of dry weight respectively), carotenoids and an almost complete set of vitamins. At the same time, in the process of cultivation, a method was developed to enrich algobiomass and its individual components (primarily the lipid fraction) with selenium, zinc, chromium, as important regulatory trace elements.
From chlorella, we obtained seleniumlipid, selenium-zinclipid and selenium-chromiumlipid complexes, and their constancy and structure were grounded by chromatographic and mass spectrometric analysis. After feeding healthy rats with a starch solution of selenium-zinclipid complex (1 ml of which contained 0.4 μg of selenium, 2.5 μg of zinc and 0.5 mg of lipids) and selenium-chromiumlipid complex (1 ml contained 1.85 μg of selenium, 1.1 μg of chromium, 0,45 mg of lipids), no signs of intoxication were found (total medium molecular peptides content was reduced to 1.5 times, the content of TBA-active products and diene conjugates were also decreased), antioxidant processes (increase of glutathione content and activity of glutathione peroxidase while reducing the functional role of catalase) were activated (by increasing of succinate dehydrogenase and cytochrome oxidase activity, glutamate dehydrogenase - the way of glutamate formation), which contributed to the successful functioning of the antioxidant system and maintenance of energy and metabolic homeostasis in the body.
The obtained results enable the use of biologically active additives from chlorella, enriched with trace elements Se (IV), Zn (II) and Cr (III), as promising therapeutic and prophylactic substances, which will contribute to the successful functioning of the antioxidant system, maintain energy metabolism and metabolism correction of pathological processes, which is the basis for further studies of the biological activity of the complexes under study.
Avaliação da saúde bucal de pacientes portadores de diabetes mellitus tipo II atendidos em uma Unidade Básica de Saúde no Estado do Amazonas
Authors: Sarmento Maria das Graças Silva , Da Silva Michelli Domingos , Crainey James Lee 
Published: March 2021

Objetivo: Este relato de experiência tem o objetivo de avaliar e descrever a luz da literatura sobre a saúde bucal dos pacientes portadores de diabetes mellitus tipo II atendidos na Unidade Básica de Saúde no Estado do Amazonas. Relato de experiência: Trata-se de um estudo descritivo, do tipo relato de experiência, acerca do período em atendimento de saúde bucal em portadores de diabetes mellitus, em uma unidade básica de saúde no Estado do Amazonas no período de janeiro a dezembro de 2019. Foi vivenciado que existe um alto índice de pessoas com dentes permanentes cariados, perdidos e obturados (CPOD), diabéticos através do atendimento especializado na UBS. A UBS conta hoje com equipes de saúde especializadas, e visa controlar a glicemia do paciente durante o tratamento odontológico. Os auxiliares de saúde bucal e os odontólogos, podem contribuir para melhora da qualidade de vida desses pacientes, ficando responsável pela realização de uma boa higiene oral. Considerações finais: Com relação as condições de saúde bucal, foi confirmado um auto índice de diabéticos que possui o índice de dentes cariados e obturados mais elevado, necessita de maior intervenção periodontal e classicamente evidenciou-se maiores problemas periodontias neste grupo.
The Effect of Topical Dapsone In Comparison With Tacrolimus On Dncb Induced Atopic Dermatitis In Mice
Authors: Aws D. Yousif  , Ahmed R. Abu-Raghif  
Published: March 2021

To assess the effect of topical dapsone in the treatment of atopic dermatitis in comparison with tacrolimus. A case-control study was done on 80 male Albino mice (20-30g) recruited from local markets, were treated with 1-Chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis and compared with age and the sex-matched control group comprised of 20 healthy male Albino mice. The topical applications of Tacrolimus 0.1% ointment and Dapsone 5% gel were performed on atopic dermatitis area for seven days and fourteen days once daily starting from the fourth day of induction and Complete blood count, IL-4 and IL-13 were measured in skin tissue homogenate in addition to histopathological evaluation of atopic dermatitis skin lesion and assessment of observational severity score and compared with those of controls. The results revealed that the levels of IL-4 and IL-13, total WBC, observational severity score, and the score of all histopathological markers were increased significantly in the group of mice treated with 1-Chloro-2,4-dinitrobenzene (DNCB) for A.D. induction in comparison with controls. These markers were reduced significantly after the topical application of tacrolimus. They showed a comparable reduction but after a longer duration of topical treatment with dapsone after two weeks of treatment. Topical application of dapsone on induced A.D. mice showed a significant reduction in the levels of IL-4 and IL-13, total WBC, observational severity score, and histopathological markers score and these effects were compared to those of topical tacrolimus.