bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program
Authors: Tang Ke , Zhu Liyan , Chen Jie , Wang Dianheng , Zeng Liping , Chen Chen , Tang Liang , Zhou Li , Wei Keke , Zhou Yabo , Lv Jiadi , Liu Yuying , Zhang Huafeng , Ma Jingwei , Huang Bo 
Published: August 2021

Abstract

Hypoxia is known to be commonly present in breast tumor microenvironments. Stem-like cells that repopulate breast tumors, termed tumor-repopulating cells (TRC), thrive under hypoxic conditions, but the underlying mechanism remains unclear. Here, we show that hypoxia promotes the growth of breast TRCs through metabolic reprogramming. Hypoxia mobilized transcription factors HIF1α and FoxO1 and induced epigenetic reprogramming to upregulate cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme that initiates gluconeogenesis. PCK1 subsequently triggered retrograde carbon flow from gluconeogenesis to glycogenesis, glycogenolysis, and the pentose phosphate pathway. The resultant NADPH facilitated reduced glutathione production, leading to a moderate increase of reactive oxygen species that stimulated hypoxic breast TRC growth. Notably, this metabolic mechanism was absent in differentiated breast tumor cells. Targeting PCK1 synergized with paclitaxel to reduce the growth of triple-negative breast cancer (TNBC). These findings uncover an altered glycogen metabolic program in breast cancer, providing potential metabolic strategies to target hypoxic breast TRCs and TNBC.

Significance:
Hypoxic breast cancer cells trigger self-growth through PCK1-mediated glycogen metabolism reprogramming that leads to NADPH production to maintain a moderate ROS level.
ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression
Authors: Sheldon Helen , Bridges Esther , Silva Ildefonso , Masiero Massimo , Favara David M. , Wang Dian , Leek Russell , Snell Cameron , Roxanis Ioannis , Kreuzer Mira , Gileadi Uzi , Buffa Francesca M. , Banham Alison , Harris Adrian L. 
Published: August 2021

Abstract

ELTD1/ADGRL4 expression is increased in the vasculature of a number of tumor types and this correlates with a good prognosis. Expression has also been reported in some tumor cells with high expression correlating with a good prognosis in hepatocellular carcinoma (HCC) and a poor prognosis in glioblastoma. Here we show that 35% of primary human breast tumors stain positively for ELTD1, with 9% having high expression that correlates with improved relapse-free survival. Using immunocompetent, syngeneic mouse breast cancer models we found that tumors expressing recombinant murine Eltd1 grew faster than controls, with an enhanced ability to metastasize and promote systemic immune effects. The Eltd1-expressing tumors had larger and better perfused vessels and tumor–endothelial cell interaction led to the release of proangiogenic and immune-modulating factors. M2-like macrophages increased in the stroma along with expression of programmed death-ligand 1 (PD-L1) on tumor and immune cells, to create an immunosuppressive microenvironment that allowed Eltd1-regulated tumor growth in the presence of an NY-ESO-1–specific immune response. Eltd1-positive tumors also responded better to chemotherapy which could explain the relationship to a good prognosis observed in primary human cases. Thus, ELTD1 expression may enhance delivery of therapeutic antibodies to reverse the immunosuppression and increase response to chemotherapy and radiotherapy in this subset of tumors. ELTD1 may be useful as a selection marker for such therapies.

Implications:
ELTD1 expression in mouse breast tumors creates an immunosuppressive microenvironment and increases vessel size and perfusion. Its expression may enhance the delivery of therapies targeting the immune system.
Measured Versus Estimated Resting Metabolic Rate in Heart Failure With Preserved Ejection Fraction
Authors: Anderson Theresa , Cascino Thomas M. , Koelling Todd M. , Perry Daniel , Grafton Gillian , Houston Denise K. , Upadhya Bharathi , Kitzman Dalane W. , Hummel Scott L. 
Published: August 2021

Background:
Obesity is common in heart failure with preserved ejection fraction (HFpEF), and a hypocaloric diet can improve functional capacity. Malnutrition, sarcopenia, and frailty are also frequently present, and calorie restriction could harm some patients. Resting metabolic rate (RMR) is an essential determinant of caloric needs; however, it is rarely measured in clinical practice. The accuracy of commonly used predictive equations in HFpEF is unknown.

Methods:
RMR was measured with indirect calorimetry in 43 patients with HFpEF undergoing right heart catheterization at the University of Michigan, and among 49 participants in the SECRET trial (Study of the Effects of Caloric Restriction and Exercise Training in Patients With Heart Failure and a Normal Ejection Fraction); SECRET patients also had dual-energy X-ray absorptiometry body composition measures. Measured RMR was compared with RMR estimated using the Harris Benedict, Mifflin-St Jeor, World Health Organization, and Academy for Nutrition and Dietetics equations.

Results:

All predictive equations overestimated RMR (by >10%,
P
<0.001 for all), with mean (95% CI) differences Harris Benedict equation +250 (186–313), Mifflin-St. Jeor equation +169 (110–229), World Health Organization equation +300 (239–361), and Academy for Nutrition and Dietetics equation +794 (890–697) kcal/day. Results were similar across both patient groups, and the discrepancy between measured and estimated RMR tended to increase with body mass index. In SECRET, measured RMR was closely associated with lean body mass (ρ=0.74; by linear regression adjusted for age and sex: β=27 [95% CI, 18–36] kcal/day per kg,
P
<0.001; r
2
=0.56).

Conclusions:
Commonly used predictive equations systematically overestimate measured RMR in patients with HFpEF. Direct measurement of RMR may be needed to effectively tailor dietary guidance in this population.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT00959660.
Safety of Endomyocardial Biopsy in New-Onset Acute Heart Failure Requiring Veno-Arterial Extracorporeal Membrane Oxygenation
Authors: van der Boon Robert M.A. , den Dekker Wijnand K. , Meuwese Christiaan L. , Lorusso Roberto , von der Thüsen Jan H. , Constantinescu Alina C. , Manintveld Olivier C. , Delnoij Thijs S.R. , van der Heijden Joris. J. , van Mieghem Nicolas M.D.A. , den Uil Corstiaan A. 
Published: August 2021

Background:
Endomyocardial biopsy (EMB) has an important role in determining the pathogenesis of new-onset acute heart failure (new-AHF) when noninvasive testing is impossible. However, data on safety and histopathologic outcomes in patients requiring veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is lacking.

Methods:
A retrospective, multicenter cohort of patients undergoing EMB while requiring VA-ECMO for new-AHF between 1990 and 2020 was compared with a cohort of nontransplant related biopsies not requiring VA-ECMO. Primary end point of the study was to determine the safety of EMB. Additionally, we describe the underlying pathogenesis causing new-AHF based on histopathologic examination of the samples obtained.

Results:

A total of 23 patients underwent EMB while requiring VA-ECMO (10.0%), 125 (54.3%) during an unplanned admission, and 82 (35.7%) in elective setting. Major complications occurred in 8.3% of all procedures with a significantly higher rate in patients requiring VA-ECMO (26.1% versus 8.0% versus 3.7%,
P
=0.003) predominately due to the occurrence of sustained ventricular tachycardia or need of resuscitation (13.0% versus 3.2% versus 1.2%,
P
=0.02). EMB led to a histopathologic diagnosis in 78.3% of the patients requiring VA-ECMO which consisted primarily of patients with myocarditis (73.9%).

Conclusions:
EMB in patients requiring VA-ECMO can be performed albeit with a substantial risk of major complications. The risk of the procedure was offset by a histopathologic diagnosis in 78.3% of the patients, which for the majority consisted of patients with myocarditis. The important therapeutic and prognostic implications of establishing an underlying pathogenesis causing new-AHF in this population warrant further refinement to improve procedural safety.
Sustainable Energy for All? Assessing Global Distributive Justice in the Green Climate Fund’s Energy Finance
Authors: Dorman Diana R. , Ciplet David 
Published: August 2021

AbstractThere is growing international attention to the goal of universal energy access. Despite this, large financial gaps remain a major obstacle for realizing global energy justice for all communities. Drawing on political theories of global distributive justice, this article develops and applies a framework for how multilateral development assistance for energy projects can be evaluated in relation to three guiding principles. First, the global difference principle asserts that resources should be distributed to maximize the condition of the least well-off humans. Second, the local benefits principle asserts that resources should be distributed in ways that enhance the public goods of local communities, particularly those that are historically marginalized. Third, the global equality of opportunity principle asserts that all social groups and states have the capabilities to equitably access institutional structures relevant to the distribution of resources. We apply this framework to an analysis of finance for all energy projects within the Green Climate Fund (GCF) from 2015 to 2018. In doing so, we offer a nuanced understanding of the successes and failures regarding the performance of the GCF’s energy portfolio in relation to global distributive justice.
Neural Synchrony for Adaptive Control
Authors: Verbeke Pieter , Verguts Tom 
Published: August 2021

Abstract
Cognitive control can be adaptive along several dimensions, including intensity (how intensely do control signal influence bottom–up processing) and selectivity (what information is selected for further processing). Furthermore, control can be exerted along slow or fast time scales. Whereas control on a slow time scale is used to proactively prepare for upcoming challenges, control can also be used on a faster time scale to react to unexpected events that require control. Importantly, a systematic comparison of these dimensions and time scales remains lacking. Moreover, most current models of adaptive control allow predictions only at a behavioral, not neurophysiological, level, thus seriously reducing the range of available empirical restrictions for informing model formulation. The current article addresses this issue by implementing a control loop in an earlier model of neural synchrony. The resulting model is tested on a Stroop task. We observe that only the model that exerts cognitive control on intensity and selectivity dimensions, as well as on two time scales, can account for relevant behavioral and neurophysiological data. Our findings hold important implications for both cognitive control and how computational models can be empirically constrained.
“Mock Jewish” in Early Twentieth-Century Tunisia: Linguistic Form and Social Meaning
Authors: Koerber Benjamin 
Published: August 2021

Abstract
The article presents a sociolinguistic profile of “Mock Jewish,” or the stylized varieties of Judeo-Arabic deployed for humorous purposes in early twentieth-century Tunisian public culture. We assembled a corpus of texts from both print and audio-visual media, including newspaper columns, television and radio performances, folktales, and plays, in which “Jewish” (yahūdī) or “Israelite” (isrāʾīlī) voices are stylized with exaggerated forms of linguistic difference. The purpose of the analysis is not to evaluate the inauthenticity of Mock Jewish vis-à-vis Judeo-Arabic proper, but to understand how performers deploy these markedly “Jewish” stylistic tactics to create diverse social meanings and assess the effects of these performances on language and society. We argue that Mock Jewish forms part of the broader “ideologies of linguistic differentiation” that construct Jewish speech as separate and distinct from non-Jewish varieties. However, the performances of Mock Jewish are not limited to sectarian polemic, but engage diverse targets, derive from different motivations, and provoke divergent responses from audiences.
Using Disability Studies in Education (dse) and Professional Development Schools (pds) to Implement Inclusive Practices
Authors: Elder Brent C. , Givens Lesa , LoCastro Andrea , Rencher Lisa 
Published: August 2021

Abstract
This article highlights ways in which disability studies in education (dse) and professional development school (pds) partnerships can be used to provide students with disability labels more access to inclusive classrooms. The authors of this qualitative exploratory case study interviewed 16 teacher and administration pds steering committee members to better understand how students with disability labels could be supported through the development and implementation of dse-informed inclusive practices. The findings indicate that instituting proactive communication structures, providing ongoing dse-informed professional development to teachers, administration, and staff, and teachers taking inclusive action increased the number of students with disability labels accessing general education classrooms. These findings, while a work in progress, show how members of one pds steering committee took steps to resist deficit models of disability and questioned traditional segregated approaches to special education at their school.
Ambivalent perceptions of the Other: Towards a dual-process sociology of intercultural relations
Authors: Høy-Petersen Nina 
Published: August 2021

Applying theories from sociology and social psychology concerned with the intersection of culture and cognition to in-depth interviews, this paper empirically explores the Norwegian majority population’s perceptions of cultural diversities using a dual-process (DP) methodological and analytic approach. Globalization has produced a mix of new anxieties, opportunities, and curiosities, leaving most people juggling conflicting objectives of self-preservation and self-realization, and making cognitive self-regulation and behavioural flexibility valorized skills of contemporary life. Instead of identifying xenophobic and cosmopolitan attitudes at opposite ends of a spectrum, the current paper argues in line with current research and theory in studies of DP cognition that they commonly co-exist, albeit in separate automatic and discursive cognitive systems, within the same individual. As a result, people’s perceptions of cultural and ethnic diversities tend to be ambivalent and contextually malleable – for example, in cases where their deep dispositions appear incompatible with their own self-concept or dominant cultural expectations. Most centrally, the current research proposes concrete strategies to elicit responses from both cognitive systems in the context of interpretive interviews. Secondly, the paper proposes clues that help to identify from which cognitive system interviewees’ conflicting cosmopolitan and xenophobic attitudes originate, thereby enabling researchers to further delineate the specific characteristics of these attitudes, including the mode of cultural learning through which they form, their flexibility or robustness to change, their role in behaviour motivation, and the extent to which they are conscious and controllable.
Characteristics, Management, and Prognosis of Spontaneous Coronary Intramural Hematoma
Authors: Chang Shufu , Dai Yuxiang , Song Xiaoyue , Li Chenguang , Lu Hao , Huang Zheyong , Ma Jianying , Qian Juying , Ge Junbo 
Published: August 2021

Spontaneous coronary intramural hematoma (SCIH) was one type of spontaneous coronary artery dissection without obvious intimal tear, which is easy to misdiagnose. We aimed to study the characteristics, management, and prognosis of SCIH in our center. All the SCIH patients (n = 30) diagnosed by coronary angiography from January 1, 2012 to December 31, 2018 were enrolled. The demographic characteristics, history, therapy, and follow-up were collected. The mean age of the patients was 51.8 ± 9.5 years. Most of the patients were females (66.7%) with hypertension. Patients with diffuse lesion, focal lesion, and multiple vessels were 70%, 13.3%, and 16.7%, respectively. Conservative treatment was the first choice (76.7%). The mean follow-up time was 29.3 ± 13.5 months. None of the patients had unplanned readmission due to worsening symptoms. Nine patients underwent coronary artery computed tomography reexamination after 10.3 ± 7.5 months, which showed complete recovery of SCIH. Eight patients were hospitalized for coronary angiography 6.4 ± 4.7 months later, which did not show any sign of SCIH. Spontaneous coronary intramural hematoma was most common in post-menopausal women with hypertension. Possibly, antiplatelet drugs should be avoided in SCIH. Waiting for the hematoma to heal was preferable and had a good prognosis.
Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection
Authors: Teama Mohammed Abd El Monem , Abdelhakam Dina A , Elmohamadi Marwa A , Badr Fatma Mohammed 
Published: August 2021

Background: As an immune modulator, vitamin D has been implicated in the coronavirus disease 2019 (COVID-19) severity. This study aimed to investigate the association between vitamin D levels and the severity of COVID-19 infection. Methods: A cross-sectional study, which included 124 patients diagnosed with COVID-19 and were selected from Ain Shams University Hospitals and assigned to two groups; mild and severe COVID-19. All patients underwent detailed history taking, clinical data, and different laboratory investigations as complete blood count, blood urea nitrogen, serum creatinine, liver enzymes, C-reactive protein, D-dimer, ferritin and serum vitamin D concentration. In addition to findings of initial chest computed tomography (CT) were recorded. COVID-19 Reporting and Data System (CO-RADS) and CT chest severity scores (CT SS) were reported. Results: In this study of 124 COVID-19-positive individuals, a high prevalence of hypovitaminosis D was found (97.6%). Lower vitamin D levels were significantly associated with more severe COVID-19 cases ( p-value < 0.001), higher blood levels of inflammatory markers including (D-dimer, CRP, and ferritin), a higher CT SS and longer disease duration. Serum vitamin D can be used as a predictor for the severity of COVID-19 infection with a specificity of 96.6%, and sensitivity of 45.5%. Conclusion: The high frequency of hypovitaminosis D in severe COVID-19 patients provides further evidence of a potential link to poor prognosis and severity of the disease, so vitamin D deficiency may be a marker of poor prognosis in these patients.
Using Standardized Videos to Examine the Validity of the Shared Decision Making Process Scale: Results of a Randomized Online Experiment
Authors: Valentine K. D. , Mancini Brittney , Vo Ha , Brodney Suzanne , Cosenza Carol , Barry Michael J. , Sepucha Karen R. 
Published: August 2021

Background The Shared Decision Making (SDM) Process scale is a brief, patient-reported measure of SDM with demonstrated validity in surgical decision making studies. Herein we examine the validity of the scores in assessing SDM for cancer screening and medication decisions through standardized videos of good-quality and poor-quality SDM consultations. Method An online sample was randomized to a clinical decision—colon cancer screening or high cholesterol—and a viewing order—good-quality video first or poor-quality video first. Participants watched both videos, completing a survey after each video. Surveys included the SDM Process scale and the 9-item SDM Questionnaire (SDM-Q-9); higher scores indicated greater SDM. Multilevel linear regressions identified if video, order, or their interaction predicted SDM Process scores. To identify how the SDM Process score classified videos, area under the curve (AUC) was calculated. The correlation between SDM Process score and SDM-Q-9 assessed construct validity. Heterogeneity analyses were conducted. Results In the sample of 388 participants (68% white, 70% female, average age 45 years) good-quality videos received higher SDM Process scores than poor-quality videos ( Ps < 0.001), and those who viewed the good-quality high cholesterol video first tended to rate the videos higher. SDM Process scores were related to SDM-Q-9 scores ( rs > 0.58; Ps < 0.001). AUC was poor (0.69) for the high cholesterol model and fair (0.79) for the colorectal cancer model. Heterogeneity analyses suggested individual differences were predictive of SDM Process scores. Conclusion SDM Process scores showed good evidence of validity in a hypothetical scenario but were lacking in ability to classify good-quality or poor-quality videos accurately. Considerable heterogeneity of scoring existed, suggesting that individual differences played a role in evaluating good- or poor-quality SDM conversations.
Transitioning Escape Rooms to a Virtual Environment
Authors: Kutzin Jared M. , Sanders Jenny E. , Strother Christopher G. 
Published: August 2021

Escape room games have gained in popularity in both entertainment and education venues over the past several year. The global health pandemic put an abrupt end to in-person escape room programs due to the enclosed space in which they take place. In an attempt to continue to utilize the escape room concept we set about to create a virtual escape room using commonly available software and assessed its usability and participant feelings about the experience. The results indicated that the participants thought the escape room was engaging (88%), that they had to work as a team (95%), and that they overall enjoyed the experience (85%). Virtual experiences cannot completely replace in-person experiences, but there are ways to introduce important teamwork and communication concepts to participants and make online meetings and conferences more engaging.
Rehabilitation Principles to Consider for Anterior Cruciate Ligament Repair
Authors: Wu Jocelyn , Kator Jamie L. , Zarro Michael , Leong Natalie L. 
Published: August 2021

Context: Injury to the anterior cruciate ligament (ACL) is among the most common orthopaedic injuries, and reconstruction of a ruptured ACL is a common orthopaedic procedure. In general, surgical intervention is necessary to restore stability to the injured knee, and to prevent meniscal damage. Along with surgery, intense postoperative physical therapy is needed to restore function to the injured extremity. ACL reconstruction (ACLR) has been the standard of care in recent decades, and advances in surgical technology have reintroduced the prospect of augmented primary repair of the native ACL via a variety of methods. Evidence Acquisition: A search of PubMed database of articles and reviews available in English was performed through 2020. The search terms ACLR, anterior cruciate ligament repair, bridge enhanced acl repair, suture anchor repair, dynamic intraligamentary stabilization, internal bracing, suture ligament augmentation, and internal brace ligament augmentation were used. Study Design: Clinical review. Level of Evidence: Level 5. Results: No exact consensus exists on effective rehabilitation protocols after ACL repair techniques, as the variation in published protocols seem even greater than the variation in those for ACLR. For some techniques such as internal bracing and dynamic interligamentary stabilization, it is likely permissible for the patients to progress to full weightbearing and discontinue bracing sooner. However, caution should be applied with regard to earlier return to sport than after ACLR as to minimize risk for retear. Conclusion: More research is needed to address how physical therapies must adapt to these innovative repair techniques. Until that is accomplished, we recommend that physical therapists understand the differences among the various ACL surgery techniques discussed here and work with the surgeons to develop a rehabilitation protocol for their mutual patients. Strength of Recommendation Taxonomy (SORT): C.