bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggressive thromboprophylaxis improves clinical process and decreases the need of Intensive Care Unit in Covid-19
Authors: Ugur Murat , Adiyeke Esra , Recep Eymen , Bakan Nurten , Yiyit Nurettin 
Published: February 2021

Background and Objectives: COVID-19 might cause thrombosis in the arterial and venous system either directly or via indirect means such as cytokine storm or hypoxia. Enoxaparin might contribute to clinical recovery in COVID-19 patients, both by reducing the risk of thrombosis with anticoagulant effect and avoiding the cytokine storm with its anti-inflammatory effect. In this study, the clinical results of prophylactic enoxaparin usage in COVID-19 patients in our hospital were investigated.
Methods: We retrospectively analyzed the patients who had hospitalized in our hospital with the diagnosis of COVID-19 between March 12 and April 17, 2020. Patients were divided into two groups according to their clinical status. Patients who were discharged to their home were in Group-I and were transferred to intensive care unit (ICU) were in Group-II. Patients’ demographics and laboratory examinations were compared between the groups. Then the effect of LMWH treatment in the rate of ICU transfer was evaluated.
Results: There were 1216 hospitalized patients with COVID-19 in the study period. Increased age, levels of D-Dimer and fibrinogen and decreased hemoglobin, platelet, lymphocyte values were found to be statistically significantly risk factor for the need of ICU. Transfer rates of ICU were two times more in the patients who did not used enoxaparin and readmission after the discharge was higher in the patients who did not received enoxaparin in the hospital.
Conclusion: Enoxaparin treatment in COVID-19 might be effective not only anticoagulant effect but also anti-inflammatory effect that decreased the risk cytokine storm. In the patients with COVID-19 disease, starting enoxaparin treatment in the earlier stage will decrease the risk of microthrombosis in vital organs and might improve the clinical outcomes.
doi: https://doi.org/10.12669/pjms.37.3.3687
How to cite this:Ugur M, Adiyeke E, Recep E, Bakan N, Yiyit N. Aggressive thromboprophylaxis improves clinical process and decreases the need of Intensive Care Unit in Covid-19. Pak J Med Sci. 2021;37(3):668-674. doi: https://doi.org/10.12669/pjms.37.3.3687
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Postoperative mobilisation as an indicator for the quality of surgical nursing care
Authors: Jakobsen Dorthe Hjort , Høgdall Claus , Seibæk Lene 
Published: February 2021

Background:Postoperative mobilisation is an important part of fundamental care. Increased mobilisation has positive effect on recovery, but immobilisation is still a challenge in postoperative care.Aims:To report how the establishment of a national nursing database was used to measure postoperative mobilisation in patients undergoing surgery for ovarian cancer.Methods:‘Mobilisation’ was defined as at least 3 hours out of bed on postoperative day 1, with the goal set at achieving this in 60% of patients. Data entry was performed by clinical nurses on 4400 patients with ovarian cancer.Findings:46.7% of patients met the goal for mobilisation on the first postoperative day, but variations in duration and type of mobilisation were observed. Of those mobilised, 51.8% had been walking in the hallway.Conclusions:A national nursing database creates opportunities to optimise fundamental care. By comparing nursing data with oncological, surgical and pathology data it became possible to study mobilisation in relation to cancer stage, comorbidity, treatment and extent of surgery.
Executing a business model change: identifying key characteristics to succeed in volatile markets
Authors: Allegretti Sebastian , Seidenstricker Sven , Fischer Heiko , Arslan Sefkan 
Published: February 2021

AbstractThe world is changing, and with it comes the requirement that enterprises change to survive in today's volatile markets. However, the change does not just include launching a new product on the market but also changing the business model of the whole organisation. To sustain in today's fast-changing markets, companies have to detect new market opportunities on time, assess them and find a way to incorporate the most beneficial opportunities into their business. Without this awareness that a company must change with the changing market, it risks losing its significance in the market. Both the change of the business model and the change of the organisation are needed to succeed in the market. An outstanding example of such a company is Netflix. They have successfully changed their business model twice: first, from an online-DVD-rental service to a streaming provider and then, to a content provider. They were aware of upcoming new technologies on-time, evaluated them and planned the implementation in the market while the old technology was still profitable. The present work outlines the major changes in Netflix's business model and how they managed the change process successfully.
Collagenous Gastritis Masquerading as Eosinophilic Gastritis
Authors: Klein Jeremy , Wilkins Benjamin J. , Verma Ritu , Muir Amanda B. 
Published: February 2021

ABSTRACT
A 11-year-old boy presented to the gastroenterology clinic after a 5-month history of fatigue, pallor, intermittent abdominal pain, and iron-deficiency anemia. Although the initial upper endoscopy was visually normally, the histological assessment was suggestive of eosinophilic gastritis. After multiple scopes and failed therapies, histologic analysis revealed a focus of thickened subepithelial collagen deposition suggestive of collagenous gastritis. A retrospective review of gastric biopsies using Gomori trichrome stain revealed previously unappreciated collagen deposition. This case report illustrates the benefit of performing trichrome stain on gastric biopsies in the setting of persistent or isolated gastric eosinophilia or iron deficiency anemia.
Bridging the Gap: Patient Navigation Increases Colonoscopy Follow-up After Abnormal FIT
Authors: Idos Gregory E. , Bonner Joseph D. , Haghighat Shida , Gainey Christina , Shen Stacy , Mulgonkar Ashwini , Otero Karla Joyce , Geronimo Christine , Hurtado Maria , Myers Caitlin , Morales-Pichardo Jennifer , Kahana Doron D. , Giboney Paul , Dea Stanley 
Published: February 2021

INTRODUCTION:
Recent studies indicate low rates of follow-up colonoscopy after abnormal fecal immunochemical testing (FIT) within safety net health systems. A patient navigation (PN) program is an evidence-based strategy that has been shown to improve colonoscopy completion in private and public healthcare settings. The aim of this study was to evaluate the effectiveness of a PN program to encourage follow-up colonoscopy after abnormal FIT within a large safety net hospital system.

METHODS:
We established an enterprisewide PN program at 5 tertiary care hospitals within the Los Angeles County Department of Health Services system in 2018. The PN assisted adult patients aged 50–75 years with an abnormal FIT to a follow-up colonoscopy within 6 months. PN activities included initiating referral for and scheduling of colonoscopy, performing reminder phone calls to patient for their upcoming colonoscopy, and following up with patients who did not attend their colonoscopy. We assess the effectiveness of the PN intervention by comparing follow-up colonoscopy rates with a period before the intervention.

RESULTS:
There were 2,531 patients with abnormal FIT results (n = 1,214 in 2017 and n = 1,317 in 2018). A majority were women (55% in 2017 vs 52% in 2018) with a mean age of 60 ± 6.2 years. From a previous mean of 163 days without PN in 2017, the mean time from abnormal FIT to colonoscopy with PN improved to 113 days in 2018. The frequency of colonoscopy completion with PN increased from 40.6% (n = 493) in 2017 to 46% (n = 600) in 2018.

DISCUSSION:
After the introduction of the PN program, there was a significant increase in patients undergoing follow-up colonoscopy after abnormal FIT and patients were more likely to undergo colonoscopy within the recommended 6 months.
Longitudinal and Circumferential Distributions of Dysplasia and Early Neoplasia in Barrett's Esophagus: A Pooled Analysis of Three Prospective Studies
Authors: Raphael Kara L. , Inamdar Sumant , McKinley Matthew J. , Martinez Nichol , Cavaliere Kimberly , Kahn Allon , Leggett Cadman L. , Iyer Prasad , Wang Kenneth K. , Trindade Arvind J. 
Published: February 2021

INTRODUCTION:
Studies have shown that dysplasia in Barrett's esophagus (BE) has a predilection for the right hemisphere. There is limited information on the longitudinal distribution. The aim was to determine both the longitudinal and circumferential distributions of dysplasia and early neoplasia from 3 prospective studies.

METHODS:
This is a pooled analysis from 3 prospective studies of patients with treatment-naive BE. Both circumferential and longitudinal locations (for BE segments greater than 1 cm) of dysplastic and early neoplastic lesions were recorded.

RESULTS:
A total of 177 dysplastic and early neoplastic lesions from 91 patients were included in the pooled analysis; of which 59.3% (n = 105) were seen on high-definition white light endoscopy, 29.4% (n = 52) on advanced imaging, and 11.2% (n = 20) with random biopsies. The average Prague score was C3M5. Of 157 lesions within BE segments greater than 1 cm, 49 (34.8%) lesions were in the proximal half, whereas 92 lesions (65.2%) were in the distal half (P < 0.001). The right hemisphere of the esophagus contained 55% (86/157) of the total lesions compared with 45% (71/157) for the left hemisphere (P = 0.02). This was because of the presence of high-grade dysplasia being concentrated in the right hemisphere compared with the left hemisphere (60% vs 40%, P = 0.002).

DISCUSSION:
In this pooled analysis of prospective studies, both low-grade dysplasia and high-grade dysplasia are more frequently found in the distal half of the Barrett's segment. This study confirms that the right hemisphere is a hot spot for high-grade dysplasia. Careful attention to these locations is important during surveillance endoscopy.
An OGC web service geospatial data semantic similarity model for improving geospatial service discovery
Authors: Miao Lizhi , Liu Chengliang , Fan Li , Kwan Mei-Po 
Published: February 2021

Abstract
Open Geospatial Consortium (OGC) Web Services (OWS) are highly significant for geospatial data sharing and widely used in many scientific fields. However, those services are hard to find and utilize effectively. Focusing on addressing the big challenge of OWS resource discovery, we propose a measurement model that integrates spatiotemporal similarity and thematic similarity based on ontology semantics to generate a more efficient search method: OWS Geospatial Data Semantic Similarity Model (OGDSSM)-based search engine for semantically enabled geospatial data service discovery that takes into account the hierarchy difference of geospatial service documents and the number of map layers. We implemented the proposed OGDSSM-based semantic search algorithm on United States Geological Survey mineral resources geospatial service discovery. The results show that the proposed search method has better performance than the existing search engines that are based on keyword-based matching, such as Lucene, when recall, precision, and F-measure are taken into consideration. Furthermore, the returned results are ranked based on semantic similarity, which makes it easier for users to find the most similar geospatial data services. Our proposed method can thus enhance the performance of geospatial data service discovery for a wide range of geoscience applications.
Subsurface structure investigation of the United Arab Emirates using gravity data
Authors: Saibi Hakim , Hag Diab Bakri , Alamri Mohammed Saeed Mohammed , Ali Hamdan Abdo 
Published: February 2021

AbstractThe crustal structure beneath the United Arab Emirates (UAE) is still relatively unknown. Here, we use regional gravity data to constrain the subsurface density distribution and structure of the crust of the UAE by applying diverse gravity derivatives methods such as horizontal derivative (HDR), analytic signal (AS), and tilt angle (TA) to analyze the subsurface structure and perform three-dimensional (3D) gravity inversion for imaging crustal structure from the surface down to 35 km depth. The results are compared with known geological regional structures and the location of the petroleum fields.The Bouguer anomalies range from −100.8 to 113.5 mGal. The 3D gravity inversion results and the maximum Bouguer values coincide with the ophiolitic Hajar mountains in the east and the successive anticlines (uplifted basement rocks) and synclines in different parts of UAE, which could be promising sites for future mining and petroleum exploration. Also, the 3D density model results and the minimum Bouguer anomalies are located over the Aruma Basin, eastern UAE Platform, and Low Central UAE Platform, which can be the places for deep groundwater aquifers. These new results from HDR, AS, and TA successfully identify known geological structures, especially in the eastern part of UAE.
Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis
Authors: Heydari Hamed , Ghiasi Rafighe , Hamidian Gholamreza , Ghaderpour Saber , Keyhanmanesh Rana 
Published: February 2021

Abstract

Objectives
High fat diet can lead to testicular structural and functional disturbances, spermatogenesis disorders as well as infertility. So, the present investigation was proposed to clarify whether voluntary exercise could prevent high fat diet induced reproductive complications in rats through testicular stress oxidative and apoptosis.

Methods
Forty male Wistar rats were randomly divided into four groups; control (C), voluntary exercise (VE), high fat diet (HFD) and high fat diet and voluntary exercise (VE + HFD) groups. The rats in the VE and VE + HFD groups were accommodated in apart cages that had running wheels and the running distance was assessed daily for 10 weeks. In VE + HFD group, animals were fed with HFD for five weeks before commencing exercise. The sperm parameters, the expressions of testicular miR-34a gene, and P53 and SIRT1 proteins as well as testicular apoptosis were analyzed in all groups.

Results
The results indicated that voluntary exercise in VE + HFD group led to significantly increased GPX and SOD activities, SIRT1 protein expression, sperm parameters, and decreased the expression of miR34a gene and Acp53 protein, and cellular apoptosis index compared to HFD group (p<0.001 to p<0.05). The SOD and catalase activities, SIRT1 protein expression, sperm parameters in VE + HFD group were lower than of those of VE group, however, MDA content, expression of Acp53 protein, apoptosis indexes in VE + HFD group was higher than that of VE group (p<0.001 to p<0.05).

Conclusion
This study revealed that voluntary exercise improved spermatogenesis, in part by decreasing the testicular oxidative stress status, apoptosis through alteration in miR-34a/SIRT1/p53 pathway.
An insight on safety, efficacy, and molecular docking study reports of N-acetylcysteine and its compound formulations
Authors: Rind Laiba , Ahmad Mohammad , Khan Mohammad Irfan , Badruddeen  , Akhtar Juber , Ahmad Usama , Yadav Chandan , Owais Mohammad 
Published: February 2021

Abstract
N-acetylcysteine (NAC) is considered as the body’s major antioxidant molecules with diverse biological properties. In this review, the pharmacokinetics, safety and efficacy report on both the preclinical and clinical summary of NAC is discussed. Both in vitro and in vivo preclinical studies along with the clinical data have shown that NAC has enormous biological properties. NAC is used in the treatment of acetaminophen poisoning, diabetic nephropathy, Alzheimer’s disease, schizophrenia, and ulcerative colitis, etc. Numerous analytical techniques, for instance, UPLC, LC-MS, HPLC, RP-IPC are primarily employed for the estimation of NAC in different single and fixed-dose combinations. The molecular docking studies on NAC demonstrate the binding within Sudlow’s site-I hydrogen bonds and formation of NAC and BSA complexes. Various hydrophobic and hydrophilic amino acids generally exist in making contact with NAC as NAC-BSA complexes. Docking studies of NAC with the active site of the urease exposed an O-coordinated bond through nickel 3002 and a hydrogen bond through His-138. NAC and its analogs also made the allosteric pockets that helped to describe almost all favorable pose for the chaperone in a complex through the protein. Thus, we intended to highlight the several health benefits of this antioxidant compound and applications in pharmaceutical product development.
NP-internal structure and the distribution of adjectives in Mə̀dʉ́mbὰ
Authors: Kouankem Constantine 
Published: February 2021

AbstractThis article discusses the structural and internal properties of adjectives in Mə̀dʉ́mbὰ, a Grassfield language spoken in the west region of Cameroon. It focuses on material inside the NP with a view towards establishing the structural positions of NP-internal constituents such as adjectives. I analyze adjectives and propose, following Scott, Gary-John. 1998. Stacked adjectival modification and the structure of nominal phrases.School of Oriental and African Studies Working Papers in Linguistics and Phonetics8. 59–89, Scott, Gary-John. 2002. Stacked adjectival modification and the structure of nominal phrases. In Guglielmo Cinque (ed.),Functional structure in DP and IP: The cartography of syntactic structures, 91–120. New York: Oxford University Press that adjectives pattern within the DP just like adverbs pattern within the clause. In Mə̀dʉ́mbὰ, an adjective can be placed before the noun, after the noun or alternatively before and after the noun. Mə̀dʉ́mbὰ adjectives can further be distinguished as belonging to three classes: pure adjectives, verbal adjectives and nominal adjectives. In this paper I focus principally on the position in which attributive adjectives are generated inside the DP. However, issues relating to the internal structure of adjectives will also be mentioned. I show that Cinque, Guglielmo. 1994. On the evidence for partial N-movement in the Romance DP. In Guglielmo Cinque, Jan Koster, Jean-Yves Pollock, Luigi Rizzi & Raffaella Zanuttini (eds.),Paths towards universal grammar, 85–110. Georgetown: Georgetown University Press, Cinque, Guglielmo. 2003. The dual source of adjectives and XP-vs. N-raising in the Romance DP.Incontro annuale di dialettologia, Padua, 26, Cinque, Guglielmo. 2010.The syntax of adjectives: A comparative study.Linguistic Inquiry Monographs. Cambridge: MIT Press), and Laenzlinger, Christophe. 2005. French adjective ordering: Perspectives on DP-internal movement types.Lingua115 views are both necessary to fully capture adjectival placement facts in Mə̀dʉ́mbὰ. Building on and refining the analysis given by these authors, I demonstrate that the type of mechanism involved in introducing adjectival modification correlates with the syntax of the adjective. On the proposal advanced here, depending on their syntactic distribution, adjectives are generated in specifier positions directly and NumP versus FP movement yields the surface structure.
Third-order differential equations with three-point boundary conditions
Authors: Cabada Alberto , Dimitrov Nikolay D. 
Published: February 2021

Abstract
In this paper, a third-order ordinary differential equation coupled to three-point boundary conditions is considered. The related Green’s function changes its sign on the square of definition. Despite this, we are able to deduce the existence of positive and increasing functions on the whole interval of definition, which are convex in a given subinterval. The nonlinear considered problem consists on the product of a positive real parameter, a nonnegative function that depends on the spatial variable and a time dependent function, with negative sign on the first part of the interval and positive on the second one. The results hold by means of fixed point theorems on suitable cones.
Study on the fabrication of in-situ TiB2/Al composite by electroslag melting
Authors: Xue Jing , Wu Wenyun , Ma Jianbo , Huang Haijun 
Published: February 2021

Abstract
In-situ TiB2 particles can be synthesized via the salts-Al reaction by adding mixed K2TiF6 and KBF4 (Ti/B=1/2) salts into Al melt. In this research, a novel electroslag melting technology was proposed to synthesize TiB2 particles by the salts-Al reaction in order to reduce the reaction time period and purify the melt of composite. The effects of current of electroslag melting on the synthesis of TiB2 particles and mechanical properties of composite were investigated. The results showed that TiB2 particles could be in-situ synthesized by electroslag melting at 600 A for 15min. Compared with 60 min at 850°C of traditional LSM method, the efficiency of preparation was greatly improved. In addition, the dispersion of TiB2 particles in the composite prepared by electroslag melting was improved, meanwhile the non-metallic inclusions in the composite was reduced. The values of YS, UTS and El pct of composite prepared by electroslag melting were higher than that of the composite prepared by traditional LSM method.
Characterization and Comparison Research on Composite of Alluvial Clayey Soil Modified with Fine Aggregates of Construction Waste and Fly Ash
Authors: Jili Qu , Junfeng Wang , Andrian Batugin , Hao Zhu 
Published: February 2021

Abstract
Fine aggregates of construction waste and fly ash were selected as additives to modify the characteristics of Shanghai clayey soil as a composite. The laboratory tests on consistency index, maximum dry density, and unconfined compressive strength were carried out mainly for the purpose of comparing the modifying effect on the composite from fine aggregates of construction waste with that from fly ash. It is mainly concluded from test results that the liquid and plastic limit of the composites increase with the content of two additives. But their maximum dry density all decreases with the additive content. However, fine aggregates of construction waste can increase the optimum water content of the composites, while fly ash on the contrary. Finally, although the two additive all can increase the unconfined compressive strength of composites, fly ash has better effect. The current conclusions are also compared with previous studies, which indicates that the current research results are not completely the same as those from other researchers.
Electrooxidation of 2-propanol on the mixture of nanoparticles of Pt and RuO2 supported on Ti
Authors: Spasojević Miroslav , Spasojević Milica , Marković Dušan , Ribić-Zelenović Lenka 
Published: February 2021

Abstract
A thermal process was employed to prepare a catalyst consisting of a mixture of metallic-Pt and rutile RuO2 nanocrystals. This catalyst was used for the electrooxidation of 2-propanol in an alkaline solution. The effect of the catalyst composition on its microstructure, surface properties and catalytic activity was examined. With increasing the RuO2 content, the catalytic activity increases, reaches its maximum and then decreases. The catalytic effect is a result of the bifunctional mechanism of the mixture of Pt and RuO2 nanocrystals. The RuOHad particles are formed on Ru atoms of the RuO2 nanocrystals at potentials more negative than on Pt atoms. These oxy-species facilitate the dehydrogenation, breaking of C–C bonds and oxidation of both 2-propanol and its intermediates, adsorbed on assemblies of adjacent Pt atoms.