bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural Politics and Conquest Culture
Authors: Aksoy Asu , Robins Kevin 
Published: November 2021

AbstractIn this article, the authors explore recent developments in urban regeneration in Istanbul, and specifically in the important historic district of Beyoğlu. In one respect, these developments, which are linked to the promotion of cruise ship tourism, are on the same predictable lines as neoliberal projects in other cities across the world. Significantly, in the Istanbul context, local agency is being sidelined, and projects are being financed and managed through the intervention of the central state. In this Turkish version of urban transformation, however, there is a locally distinctive aspect that merits attention. Istanbul is a city that was conquered by the Ottomans in 1453, and the discourse of conquest has remained significant within the urban imaginary. And at the present time, it is being mobilized by the state and its cultural ministry, in the cause of creating a new urban image conforming to its Islamist principles. The key project involves the establishment of what is called the Beyoğlu Cultural Route, which is essentially a touristic itinerary. The authors argue that the state's initiatives, and the route project in particular, involve an erasure—a conquest—of Beyoğlu's legacy of cosmopolitan values. This discussion explores what has been of civic and cultural value in the lifeworld of Beyoğlu, past and present. Resistance to the state's control of resources and institutions, and to its conquest ideology, needs to be grounded in civic principles open to diversity and difference in the city.
Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation
Authors: Tatapudy Sumitra , Peralta Jobelle , Nystul Todd 
Published: November 2021

ABSTRACT
A major goal in the study of adult stem cells is to understand how cell fates are specified at the proper time and place to facilitate tissue homeostasis. Here, we found that an E2 ubiquitin ligase, Bendless (Ben), has multiple roles in the Drosophila ovarian epithelial follicle stem cell (FSC) lineage. First, Ben is part of the JNK signaling pathway, and we found that it, as well as other JNK pathway genes, are essential for differentiation of FSC daughter cells. Our data suggest that JNK signaling promotes differentiation by suppressing the activation of the EGFR effector, ERK. Also, we found that loss of ben, but not the JNK kinase hemipterous, resulted in an upregulation of hedgehog signaling, increased proliferation and increased niche competition. Lastly, we demonstrate that the hypercompetition phenotype caused by loss of ben is suppressed by decreasing the rate of proliferation or knockdown of the hedgehog pathway effector, Smoothened (Smo). Taken together, our findings reveal a new layer of regulation in which a single gene influences cell signaling at multiple stages of differentiation in the early FSC lineage.
An epigenetic circuit controls neurogenic programs during neocortex development
Authors: Wang Andi , Wang Junbao , Tian Kuan , Huo Dawei , Ye Hanzhe , Li Si , Zhao Chen , Zhang Bo , Zheng Yue , Xu Lichao , Hua Xiaojiao , Wang Kun , Wu Qing-Feng , Wu Xudong , Zeng Tao , Liu Ying , Zhou Yan 
Published: November 2021

ABSTRACT
The production and expansion of intermediate progenitors (IPs) are essential for neocortical neurogenesis during development and over evolution. Here, we have characterized an epigenetic circuit that precisely controls neurogenic programs, particularly properties of IPs, during neocortical development. The circuit comprises a long non-coding RNA (LncBAR) and the BAF (SWI/SNF) chromatin-remodeling complex, which transcriptionally maintains the expression of Zbtb20. LncBAR knockout neocortex contains more deep-layer but fewer upper-layer projection neurons. Intriguingly, loss of LncBAR promotes IP production, but paradoxically prolongs the duration of the cell cycle of IPs during mid-later neocortical neurogenesis. Moreover, in LncBAR knockout mice, depletion of the neural progenitor pool at embryonic stage results in fewer adult neural progenitor cells in the subventricular zone of lateral ventricles, leading to a failure in adult neurogenesis to replenish the olfactory bulb. LncBAR binds to BRG1, the core enzymatic component of the BAF chromatin-remodeling complex. LncBAR depletion enhances association of BRG1 with the genomic locus of, and suppresses the expression of, Zbtb20, a transcription factor gene known to regulate both embryonic and adult neurogenesis. ZBTB20 overexpression in LncBAR-knockout neural precursors reverses compromised cell cycle progressions of IPs.
A single-molecule localization microscopy method for tissues reveals nonrandom nuclear pore distribution in Drosophila
Authors: Cheng Jinmei , Allgeyer Edward S. , Richens Jennifer H. , Dzafic Edo , Palandri Amandine , Lewków Bohdan , Sirinakis George , St Johnston Daniel 
Published: November 2021

ABSTRACT
Single-molecule localization microscopy (SMLM) can provide nanoscale resolution in thin samples but has rarely been applied to tissues because of high background from out-of-focus emitters and optical aberrations. Here, we describe a line scanning microscope that provides optical sectioning for SMLM in tissues. Imaging endogenously-tagged nucleoporins and F-actin on this system using DNA- and peptide-point accumulation for imaging in nanoscale topography (PAINT) routinely gives 30 nm resolution or better at depths greater than 20 µm. This revealed that the nuclear pores are nonrandomly distributed in most Drosophila tissues, in contrast to what is seen in cultured cells. Lamin Dm0 shows a complementary localization to the nuclear pores, suggesting that it corrals the pores. Furthermore, ectopic expression of the tissue-specific Lamin C causes the nuclear pores to distribute more randomly, whereas lamin C mutants enhance nuclear pore clustering, particularly in muscle nuclei. Given that nucleoporins interact with specific chromatin domains, nuclear pore clustering could regulate local chromatin organization and contribute to the disease phenotypes caused by human lamin A/C laminopathies.
Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson’s disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT
Authors: Takahashi Hiroto , Kashiwagi Nobuo , Arisawa Atsuko , Matsuo Chisato , Kato Hiroki , Adachi Hiroyoshi , Kajiyama Yuta , Mochizuki Hideki , Tomiyama Noriyuki 
Published: November 2021

Objective:
To assess the utility of examining the nigrostriatal system with MRI and dopamine transporter (DAT) imaging for evaluating the preclinical phase of Parkinson’s disease (PD).

Methods:
The subjects were 32 patients with early PD and a history of probable rapid eye movement sleep behavior disorder (RBD; PD group), 15 patients with idiopathic RBD (RBD group), and 24 age-matched healthy controls (HC group) who underwent neuromelanin and diffusion tensor MRI for analysis of the substantia nigra pars compacta (SNpc). The RBD and PD groups underwent DAT imaging. In the RBD group, totals of 39 MRI and 27 DAT imaging examinations were obtained longitudinally. For each value, intergroup differences and receiver operating characteristic analysis for diagnostic performance were examined statistically.

Results:
The neuromelanin value was significantly lower and the diffusion tensor values except fractional anisotropy were significantly higher in the RBD and PD groups than in the HC group. The DAT specific binding ratio (SBR) was significantly lower in the PD group than in the RBD group. The areas under the receiver operating characteristic curves (AUCs) for neuromelanin/mean diffusivity value in the SNpc were 0.76/0.82 for diagnosing RBD and 0.83/0.80 for diagnosing PD. The area under the receiver operating characteristic curves for the SBR for discriminating PD from RBD was 0.87.

Conclusion:
MRI and DAT imaging may be useful for evaluating sequential nigrostriatal changes during the preclinical phase of PD.

Advances in knowledge:
MRI detects nigrostriatal changes in both RBD and early PD, and DAT imaging detects nigrostriatal changes during the transition to PD in RBD.
Immigrants in the Grand Duchy of Luxembourg and Its Public Security
Authors: Olbrycht Paweł 
Published: November 2021

The Grand Duchy of Luxembourg is one of the smallest European countries – both in terms of area and population. As in the case of the so-called European micro-states (with less than 500,000 inhabitants – Luxembourg alone has slightly more), it is characterized by a high economic level, especially the living standards of its inhabitants.
As the Organisation for Economic Co-operation and Development’s statistical data show (official OECD website), the Grand Duchy of Luxembourg is the wealthiest Member State of the European Union in terms of average annual income per capita (gross domestic product per capita). Due to this fact, foreigners-immigrants continuously come to this country by seeking better living conditions there. It was, therefore, reasonable to explore how this high proportion of immigrants in Luxembourg’s society influences the public security of that country. Luxembourg has one of the highest economic immigration rates in Europe, the number of its citizens is continually growing, and yet the crime rates are among the lowest in the world.
The article aims to explore the impact of the presence of many immigrants in the Grand Duchy of Luxembourg on public security of that country. The article focuses on the main threat to public safety, i.e., crime – in the analysed case: the crime committed by foreigners-immigrants.
The main research problem took the form of the question: To what extent does the presence of a significant number of immigrants affect the public safety of the Grand Duchy of Luxembourg? The main hypothesis took the form of the assumption that the presence of large numbers of immigrants does not have a significant adverse effect on the public safety of the Grand Duchy of Luxembourg.
The adopted research method was the analysis of statistical data using the technique of content analysis (desk research). World Bank statistics were used as the primary source of information, while articles from scientific journals and reports from Luxembourg public administration bodies as supplementary sources.
To deepen the exploration and understanding of the migration conditions of the Grand Duchy of Luxembourg, the article presents its history as well as economic and social characteristics.
The research was carried out as part of the Research Project No. 146/WNB/65/DzS called: “The Migration Policy of the Republic of Poland as an Indicator of Its Internal Security”, carried out at Faculty of Security Studies of General Tadeusz Kościuszko Military University of Land Forces (Wrocław, Poland).
Analysis of the frequency of maxillary sinus pathology among male and female adults
Authors: Cherkes M. , Student V. , Masna Z. , Ivasivka K. , Rudnytska Kh. 
Published: November 2021

The maxillary sinuses diseases are an actual clinical problem today. The aim of our study was to determine the frequency of pathology of the maxillary sinuses of different origin and its age dynamics in adults.
500 series of anonymized tomograms of adults were analyzed: 22-35 years (1st group) and 36-60 years (2nd group in men) and 36-55 years (2nd group in women). Cone-beam computed tomography (CT) of the nose, paranasal sinuses, and upper jaw was performed on a Point 3D Combi 500 cone-beam tomograph. RealScan software was used to analyze the test results.
The results of the study showed that among the adults who applied for examination of the maxillary sinus, only 20% had no pathology. Patients of the first age group are most often diagnosed with pathological changes of the maxillary sinus, which have a rhinogenic origin. In persons of the second age group, regardless of gender, the pathology of the maxillary sinus of odontogenic origin is most often diagnosed. With age, the number of pathologies of odontogenic origin increase both in men and in women, and the number of pathologies of other origin, including rhinogenic - decreases.
Main factors that cause negative complications of foot function after receiving mechanical traumatic injuries
Authors: Sokol V. 
Published: November 2021

The article is devoted to an important and relevant area of ​​forensic and clinical research to clarify and implement in medical theory and practice the main factors that cause negative complications of lower extremity function after fractures and other injuries due to mechanical trauma during traffic accidents ( further - road accident) and lead to permanent disability of more than 33%. Therefore, the aim of the study was to identify the criteria that indicate the occurrence of severe consequences of mechanical injury in the form of permanent disability of more than 33%, and to determine the value of these prognostic criteria.
The material of the study was 180 forensic examinations and tests and medical records of victims of road accidents. Of these, 120 examinations and research - the main group, and 60 - control. A number of current legal documents describing the concepts and types of disability have also been studied.
The methods were scientific analysis of legal sources and methods of descriptive statistics of medical and forensic documentation.
The results of the study allowed us to identify 8 groups of symptoms that cause the negative consequences of post-traumatic changes in the form of permanent disability of more than 33%. Based on the study of these signs, prognostic criteria for modern forensic assessment of the severity of injuries burdened with loss of general ability to work in the above range were developed.
The ranking of these prognostic criteria in the main group (voters) was carried out.
A number of clinical and forensic features of modern forms and types of mechanical trauma of the lower extremities during an accident and the consequences of such injuries have been identified.
A number of inconsistencies of by-laws regulating forensic medical examination in the field of glossary on permanent disability are shown.
Conclusions and recommendations for improving the theory and practice of forensic determination of the degree of disability are given.
Children's feelings and attitude towards medical contacts
Authors: Wojtera Bartosz , Bugaj Agnieszka , Jackowska Joanna 
Published: November 2021

Introduction and purpose
Medical procedures can be physically harmful and cause psychological trauma among young children, possibly resulting in certain lifelong aversion. The aim of the study was to evaluate children's feelings while undergoing minor medical procedures depending on age, gender and previous experience and to compare it with university students.
Material and methods
We conducted a survey among 382 primary school children, as well as 334 university students. Questions concerned the frame of mind at the moment of examination, during dentist and general physician appointment, vaccination, hospitalization and condition of sore throat.
Results
The experience of hospital stay resulted in better feelings about possible future hospitalization in both groups, and about dentist appointment in the group of children. Girls and women declared lower mood during general physician appointment. Interestingly, in the group of children boys felt worse at the moment of survey, while in the group of students women felt so. The current frame of mind correlated with an appraisal of all other situations among students, whereas only with physician appointment and vaccination among children. All of above were statistically significant. For both groups, the most unpleasant condition was sore throat. However, in regards to medical procedures exclusively, vaccination appeared to be the most traumatic for children and hospitalization for students.
Conclusion
Earlier experience and gender of children can affect their feelings about medical procedures. Presented analysis suggests that every medical should do their best to provide pleasant atmosphere for every child during medical contacts.
Evaluation of endogenous intoxication indicators in the dynamics of experimental periodontitis and immobilization stress
Authors: Olekshij P. 
Published: November 2021

The aim of our work was to investigate the peculiarities of changes in endogenous intoxication rates: medium mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of guinea pigs in the formation of combined pathology - experimental periodontitis (EP) and immobilization stress (IS).The results of biochemical studies showed that at all stages of development of combined pathology - experimental periodontitis and immobilization stress there is a consistent increase in the degree of endogenous intoxication, which dominated on the 15th day of the experiment, namely increased content of medium mass molecules (МMМ254 , MMM280) and EII in the blood by 58.5% (p≤0.05), 80.3% (p≤0.05) and 95.7% (p≤0.05), respectively, compared with the first group of animals is a clear manifestation of the formation of endogenous intoxication. These changes are obviously the result of insufficient elimination of toxic products on the background of the inflammatory process in periodontal tissues and stress.
Age changes in the tigroid substance of neutrons of the lateral preoptic nucleus of hypothalamus under different light modes
Authors: Bulyk R. , Yosypenko V. , Kryvchanska M. , Vlasova K. , Lukan Y. 
Published: November 2021

The article presents analysis of the results of the original histochemical studies of tigroid substance of neurons of the lateral preoptic nucleus of hypothalamus in mature and old rats under the influence of different light modes. In all observations, the tigroid substance was located in the cytoplasm of neurons of the lateral preoptic nucleus of hypothalamus in the form of individual granular formations of different sizes and shapes. The amount of tigroid substance of neurons of the lateral preoptic nucleus of hypothalamus in mature rats is greater than in older rats. At the same time, it should be noted that different experimental conditions significantly affected the amount of tigroid substance in neurons of the lateral preoptic nucleus of hypothalamus in old rats. In particular, under conditions of light deprivation, the optical density of specific histochemical staining for tigroid substance in neurons of the lateral preoptic nucleus of hypothalamus increased significantly (p<0,001), and under conditions of light stimulation, on the contrary, probably decreased (p<0,001).
Kajian Pengelolaan Kawasan Mangrove Pesisir Selatan Kabupaten Bangkalan Berdasarkan UU No 1 Tahun 2014
Authors: Rosyid Daniel Mohammad , Sujantoko Sujantoko , Armono Haryo Dwito , Djatmiko Eko Budi , Wardhana Wisnu , Prastianto Rudi Walujo , Mulyadi Yeyes , Kurniati Nani , Wardhani Maulinna Kusumo 
Published: November 2021

Implementasi UU No 1 tahun 2014 dan UU No 23 tahun 2014 terlihat dalam pengelolaan kawasan hutan mangrove berada di bawah kewenangan Provinsi Jawa Timur. Namun demikian, masyarakat pesisir selatan Kabupaten Bangkalan dapat memanfaatkan sesuai dengan peraturan dan perundangan yang berlaku. Penerapan Perpres No 80 tahun 2019 dapat menjadi pendorong terbangunnya kawasan wisata di pesisir Kecamatan Modung melalui pemanfaatan sumberdaya alamnya. Pesisir Selatan Kabupaten Bangkalan berupaya membangun desa pesisir dengan zona-zona wisata. Perencanaan pengelolaan kawasan mangrove di pesisir selatan Kabupaten Bangkalan dalam revisi RTRW tahun 2020 ini diharapkan dapat dilakukan kolaborasi antara pemerintah kabupaten dan pemerintah propinsi sebagai bentuk implementasi UU No 1 tahun 2014 dan UU No 23 tahun 2014 dengan konsep pembangunan yang berkelanjutan dan terintegrasi.
Empathy is key: addressing obstacles to policy progress of ‘work-focused healthcare’
Authors: Bartys Serena , Martin Rachel , Parker Christine , Edmondson Amanda , Burton Kim 
Published: November 2021

Background:In 2019, Public Health England commissioned the authors of this paper to conduct research examining healthcare professionals’ conversations about work with their patients to inform policy aimed at reducing work loss due to ill health.
Aims and objectives:The purpose of this paper is to show how the commission provided a unique opportunity for the authors to collaborate with the funders to address obstacles to policy progress.
Methods:A steering group was established to revise the original remit of research. In outlining that process here, qualitative data collected from a wide range of healthcare professionals as part of the commission are presented for the first time. We are able to further illuminate and expand on the previously published report findings and policy recommendations, revealing novel insights on researcher-policy engagement.
Findings:Robust implementation of ‘work-focused healthcare’ policy has been limited, resulting in an overwhelming lack of empirical data and misguided directives. However, the existing evidence did provide important information about obstacles to policy progress and how to overcome them. The qualitative data were instrumental in this respect, with healthcare professionals revealing various interpretations of, and discourse on the policy.
Discussion and conclusions:This paper adds to the expanding literature which suggests that long term, mutualistic, collaborative working is central to addressing barriers to improving evidence use and mobilising health policy into practice. It was shown that tacit, generous, open, empathic and ongoing knowledge exchange, advocacy, and alliances are needed.
High Q-factor plasmonic filter based on MIM structures and its application in the design of a dual band demultiplexer for optical communication wavelengths
Authors: Abdolalipour Fatemeh , Pourmahyabadi Maryam 
Published: November 2021

One of the key components in optical integrated circuits is bandpass filters. In this article, a scheme of plasmonic filters consisting of a nanodisk cavity coupled with two

T

-shaped metal–insulator–metal (MIM) waveguides is presented. The nanodisk cavity is in a square or rectangular shape. The effects of the geometrical parameters variations on the transmission spectrum are investigated. The results of the numerical simulation analysis indicate that the perfect transmission peak can be achieved by optimizing the structure parameters. Hence, the appropriate dimensions of this structure for operating in the optical communication wavelength range (from

O

to

L

bands) are obtained. Also, the proposed filter exhibits the transmission peak of 0.99 and the high quality factors (

Q

-factors) of 91 and 109.25 at the wavelengths of 1550 nm and 1310 nm, respectively. In addition, a design of two-channel demultiplexer is presented, in which the waveguides are connected by

T

or

Y

junctions. The results show that the proposed structure exhibits the transmission peaks of 0.8 and 0.67 and the

Q

-factors of 65 and 103.3 at the resonance wavelengths of 1310 nm and 1550 nm, respectively.