bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract W P140: Post-stroke Oculomotor Abnormalities evident during Objective Eye Tracking but Not under Clinical Assessment
Authors: Rizzo John-Ross , Hudson Todd , Kowal Briana , Wiseman Michal , Raghavan Preeti 
Published: July 2021

Introduction:
Visual abnormalities and manual motor control have been studied extensively after stroke, but an understanding of oculomotor control post-stroke has not.

Recent studies have revealed that in visually guided reaches arm movements are planned during eye movement execution, which may contribute to increased task complexity. In fact, in healthy controls during visually guided reaches, the onset of eye movement is delayed, its velocity reduced, and endpoint errors are larger relative to isolated eye movements.
Our objective in this experiment was to examine the temporal properties of eye movement execution for stroke patients with no diagnosed visual impairment. The goal is to improve understanding of oculomotor control in stroke relative to normal function, and ultimately further understand its coordination with manual motor control during joint eye and hand movements.
We hypothesized that stroke patients would show abnormal initiation or onset latency for saccades made in an eye movement task, as compared to healthy controls.

Methods:
We measured the kinematics of eye movements during point-to-point saccades; there was an initial static, fixation point and the stimulus was a flashed target on a computer monitor. We used a video-based eye tracker for objective recording of the eye at a sampling frequency of 2000 Hz (SR Research, Eyelink). 10 stroke subjects, over 4 months from injury and with no diagnosed visual impairment, and 10 healthy controls completed 432 saccades in a serial fashion.

Results:
Stroke patients had significantly faster onset latencies as compared to healthy controls during saccades (99.5ms vs. 245.2ms, p=0.00058).

Conclusion:
A better understanding of the variations in oculomotor control post-stroke, which may go unnoticed during clinical assessment, may improve understanding of how eye control synchronizes with arm or manual motor control. This knowledge could assist in tailoring rehabilitative strategies to amplify motor recovery. For next steps, we will perform objective eye and hand recordings during visually guided reaches post-stroke to better understand the harmonization or lack thereof after neurologic insult.
Abstract 173: A Novel Dual Function Molecule for the Treatment of Acute Ischemic Stroke
Authors: Kuo Tun-Hsun , Peng Hsiao-Yu , Fu Ru-Huei , Yeh Sheng-Wen , Huang Wendy 
Published: July 2021

Rapid restoration of blood flow to ischemic brain is essential to prevent irreversible tissue injury and minimize neuronal function impairment after acute ischemic stroke. However, intracerebral hemorrhage, reperfusion injury and the oxidative stress provoked by returned blood supply remain the major concerns for the use of effective thrombolytic agent; such as, recombinant tissue plasminogen activator (rt-PA). DC009 is a novel small molecule designed to have both thrombolytic and free radical scavenging activities, which were characterized in various in vitro and in vivo models.
The thrombolytic effect of DC009 was demonstrated in vitro using whole blood clot lysis assay and euglobulin clot lysis assay. In comparison to rt-PA (1mg/ml), DC009 (11.11 mg/ml) exerts comparable (p value = 0.40) in vitro thrombolytic activity to rt-PA. Further investigation showed that DC009 induced endogenous t-PA protein secretion from endothelial vesicles, and it enhanced endothelial t-PA mRNA expression through cAMP pathway. Ability of DC009 in ABTS radical cation scavenging (2, 2-azinobis-(3-ethylbenzthiazoline-6-sulfonate) was measured and found to be dose dependent with an EC50 of 49 μM.
Using a focal cerebral ischemia induced by arterial thrombosis model in aged mice (12-15 months old), DC009 showed a steady thrombolytic action and superior safety profile compared to vessel recanalization induced by rt-PA.
We further investigated DC009’s effect on normal hemostasis and maximal tolerable dose (MTD) level in rodents in order to assess its therapeutic potential. At their comparable pharmacological dose, the tail amputation bleeding assay in mice showed that DC009 (up to 30mg/kg) did not cause bleeding prolongation; vs. rt-PA (10mg/kg) prolonged the bleeding to >10 folds of normal bleeding time. According to the MTD determined in preliminary toxicity dose range finding studies, greater 50 folds of safety margin was identified in both mouse and rat.
In conclusion, DC009 appears to both thrombolytic and free radical scavenging with minimal risk of bleeding. As a safe and dual functional small molecule, it is a drug candidate of great potential for the treatment of ischemic stroke.
Abstract 214: Corticospinal Tract Integrity is Acutely Maintained Within Perihematoma Edema
Authors: McCourt Rebecca , Misaghi Ehsan , Guinand Taurian , Kate Mahesh , Gioia Laura , Treit Sarah , Beaulieu Christian , Butcher Ken 
Published: July 2021

Background:
Perihematoma edema in intracerebral hemorrhage (ICH) is thought to be associated with tissue injury. Fractional Anisotropy (FA), as measured with Diffusion Tensor Imaging (DTI), can be used to assess white matter integrity. We tested the hypotheses that sections of the Corticospinal Tract (CST) passing directly through edema would 1) have low FA relative to the entire tract and 2) predict motor score in ICH patients.

Methods:
Patients were prospectively imaged with DTI within 14 days of symptom onset. Hematoma volume was measured on CT using planimetric techniques. Edema volume was assessed on CT using a 5-23 Hounsfield Unit threshold. Mean FA was measured in the edematous region (‘perihematoma edema'), the entire ipsilateral CST, and in the portion of CST passing through the perihematoma edema ('edematous CST'). Motor function was evaluated with a composite of the upper and lower extremity NIHSS motor score (0=normal, 8=hemiplegia).

Results:
Patients (n=27, mean age 67±13) were scanned with DTI at a median of 2 (3) days. Hematoma distribution was: lobar 5 (18%), basal ganglia 21 (78%), and brainstem 1 (4%). Median acute ICH volume was 8.2 (22) ml at 2 (2)h. Acute edema volume was 0.9 (1.8) ml and grew to 1.9 (3.9) ml at 26h (26). NIHSS motor score was 3 (6) at 72h and 3 (7) at day 7.

FA in the edema was significantly lower (0.23±0.06) than in contralateral mirror regions (0.37 ±0.07, p<0.0001). Mean FA in the edematous CST was lower (0.34±0.08) than FA in the entire ipsilateral CST (0.44±0.04, p<0.0001), but higher than FA in the perihematoma edema (0.25±0.06, p<0.0001).
There was a weak correlation between FA in the edematous CST and 72h motor score (r= -0.40, p=0.050,) which disappeared at day 7 (r= -0.34, p=0.131). FA in the edematous CST was not related to time to scan (r=-0.027, p=0.892).
Hematoma volume predicted FA in the edematous CST (ß=-0.46, 95% CI:[-0.05- -0.01]; p=0.015). Perihematoma edema volume did not predict FA in the edematous CST independently of the ICH (ß=-0.29, [-0.1-0.04]; p=0.475).

Conclusion:
FA is decreased in the CST where it passes through the edema, though not to the extent of the surrounding edema. The transient relationship between decreased FA and motor function suggests that edema temporarily impairs tract function but not integrity.
Abstract TP75: Safety and Outcome of Thrombolysis in Acute Stroke with Prolonged Onset-to-Treatment Times and Low National Institute of Health Stroke Scale Scores. Report on Experience in China, First 1000 Patients of 3300 Treated
Authors: Zhang Pei-Lan , Wang Jin-Huan , Wang Yu-Xin , Chen Yan , Zhang Chen-Hao , Li Chen-Hua , Dong Zhong , Liang Jing , Wang Zuo , Oliverio Patrick J , Greenberg Edward D , Vyas Nilesh , Eberly Lewis B , Cochran John W 
Published: July 2021

Introduction:
Stroke in China is the leading cause of death. We report on a collaboration between a large metropolitan hospital in China, Tianjin Huanhu Hospital, and Inova Fairfax and Inova Alexandria Stroke Programs presenting data on the first 1000 (of more than 3300 treated since 2012) patients treated with IV-rtPA. The safety and efficacy of treatment with rtPA between 4.5-6 hours after onset is unclear. Similarly there is little data on outcome of patients treated with rtPA with normal or low NIHSS.

Methods:
Patients were treated with thrombolysis between late 2012 and fall of 2014. Patients had MRI scans at 24 hours. Patients had NIHSS scores before and after treatment, and modified Rankin Scores (mRS) at 90 days after treatment.

Results:
See Chart.

Conclusions:

1) IV-rtPA can be given safely between 4.5-6 hours without significant risk of sICH and worsening outcomes.
2) Higher NIHSS before thrombolysis was correlated with poorer outcomes.
3) There was no significant correlation between onset to treatment time up to 6 hours and outcome.
4) Outcome was excellent (mRS 0-1) in 72% treated 0-3 hours, 74% 3-4.5 hours and remarkably 85% 4.5-6 hours.
The data set includes many patients who were asymptomatic or nearly so prior to treatment. This will need to be more fully evaluated in the remainder (2300) of this cohort of more than 3300 treated patients.

Comment:
This cohort represents one of the largest series of acute stroke patients treated with IV-rtPA > 4.5 hours after onset. It also reveals outcome of treatment in patients with low NIHSS treated at various intervals after last know well.
Abstract WP40: CT-based Evaluation is Faster and as Precise as MRI in Acute Stroke Evaluation
Authors: Hansen Christine K , Christensen Anders , Havsteen Inger , Christensen Hanne 
Published: July 2021

Introduction:
The issue if Computer Tomography (CT) or Magnetic Resonance Imaging (MRI) are ‘best’ in evaluation of patients with symptoms of acute stroke prior to intravenous-tissue-plasminogen-activator treatment (iv-tPA) has been widely discussed; CT-based door-to-needle-times of 20 minutes are feasible and motivated by time-dependent efficacy of iv-tPA, but the more time consuming MRI-based evaluation likely provides additional information on hyper-acute cerebral ischemia and iv-tPA-contraindicating stroke mimicking pathology.

Aim:
The aim of this study was to compare the delay of iv-tPA-treatment and the level of diagnostic information obtained for patients randomized to CT and MRI-based acute stroke evaluation.

Method:
Three-hundred-sixty-nine consecutive patients admitted with symptoms of stroke within 4.5 hours from symptom-onset were quasi-randomized to CT or MRI-based evaluation as part of an ongoing single-center trial and treated with iv-tPA if eligible.

Door-to-needle-times for patients, allocated to CT and MRI, were compared. Imaging of diagnostic quality and stroke mimicking detected pathology were registered for the two modalities.

Results:
Door-to-needle-times for CT evaluated patients (median 26 (7-55) min) were significantly faster than for MRI-examined patients (median 36 (11-71) min), p=0.007.

Imaging of adequate diagnostic quality was acquired for all patients examined with CT and for 96.4% of patients, without inherent MRI-contraindications, examined with MRI.
All patients with discharge diagnoses of intracerebral hemorrhage and intracerebral oncological pathology were identified by the primary scan at admission, regardless if CT or MRI were performed.

Conclusion:
CT-based evaluation prior to iv-tPA-treatment is faster and as presice as MRI-based evaluation of patients with acute stroke.
Religion and Government in Hugo Grotius’s Annales: Orthodoxy, William the Silent and Reason of State
Authors: Waszink Jan 
Published: July 2021

Abstract
In Grotius’s Annales, religion appears almost exclusively as a social and political problem. References (implied or explicit) to religion as a good thing or its positive effects are lacking. This aspect of Grotius’s text arises from its equation of ‘religion’ with ‘combative orthodox religion in the post-reformation era’. However, it is not credible that this view represents Hugo Grotius’s actual opinion of the Christian faith as such. The solution seems rather that the above equation must be a conscious rhetorical strategy designed to strengthen the argument of the Annales. Continuing from that conclusion, however, the texts allow us to deduce some views on reason of state and religious policy, which do seem to have been actually held by Grotius in this period, or at least to have enjoyed his active interest.
Challenges in Treating Chlamydia trachomatis, Including Rectal Infections: Is It Time to Go Back to Doxycycline?
Authors: Kang-Birken S. Lena 
Published: July 2021

Objective: To evaluate recent publications on efficacy of single-dose azithromycin and 7-day doxycycline when treating Chlamydia trachomatis. Data Sources: A literature search of MEDLINE, EMBASE, PubMed, and Cochrane library was conducted (1990 to June 13, 2021) using the terms: Chlamydia trachomatis, genital chlamydia, rectal chlamydia, extragenital chlamydia, azithromycin, doxycycline, and treatment guidelines. ClinicalTrials.gov was searched to identify ongoing trials. Study Selection and Data Extraction: English language studies, including controlled studies, retrospective analyses, systematic reviews, meta-analyses, and case reports, reporting microbiological or clinical outcomes in adolescents and adults were considered. Data Synthesis: Systemic reviews and meta-analyses of randomized trials reported azithromycin efficacy of 96% to 97% in genital chlamydia. However, reports of treatment failure have emerged, especially among symptomatic males, with an increased risk of microbiological failure after azithromycin than doxycycline (relative risk = 2.45; 95% CI = 1.36-4.41). Retrospective analyses and prospective observational cohort studies reported lower efficacy range following azithromycin than doxycycline (74%-87% vs 92%-100%, respectively) in rectal chlamydia. First randomized controlled trial comparing azithromycin and doxycycline reported significantly higher microbiological cure following doxycycline, with absolute difference of 26% (95% CI = 16%-36%; P < 0.001). The proposed 2021 Centers for Disease Control and Prevention treatment guidelines designate doxycycline as the preferred agent for treatment at any site. Relevance to Patient Care and Clinical Practice: A growing body of evidence for treatment failure following azithromycin, especially in rectal chlamydia supports updating current practice. Conclusions: Doxycycline continues to achieve high efficacy in genital and rectal chlamydia. Clinicians should consider efficacy with convenience of dosing regimen, medication compliance, and sexual behavior risks when treating chlamydia infections.
The impact of COVID-19 related national lockdown on ophthalmic emergency in Italy: A multicenter study
Authors: Salvetat Maria L , Salati Carlo , Busatto Patrizia , Zeppieri Marco 
Published: July 2021

Purpose: To assess ocular pathologies admitted to Italian Emergency Eye Departments (EEDs) during the COVID-19 pandemic national lockdown in 2020 in comparison with the same period in 2019. Methods: Electronic records of all patients presenting at EEDs of two tertiary-care Eye Centers during the COVID-19 national lockdown in Italy (March 10–May 3, 2020) were compared with the equivalent period in 2019. Main outcomes were patient age, gender, and diagnoses. Statistical analysis included unpaired Student t-tests, Poisson regression, and chi-square test. Results: Overall EED visits significantly decreased by 54.1% during the 2020 lockdown compared to 2019 (851 vs 1854, p < 0.001). During lockdown, patients showed comparable mean age (52.8 years in 2020 vs 53.3 years in 2019, p = 0.52) and significant male gender bias (61.1% in 2020 vs 55.8% in 2019, p < 0.0001). The most frequent pathologies were eye inflammations, trauma-related incidents, and spontaneous acute vitreous detachment. Patients with inflammation, headache/hemicrania, and spontaneous subconjunctival hemorrhages were significantly less, whereas those with trauma-related diagnoses were significantly higher during the lockdown as compared with 2019 ( p < 0.05). The proportion of non-urgent visits decreased from 17% in 2019 to 8% in 2020 ( p < 0.001). Conclusions: During the 2020 lockdown, there was a significant reduction of accesses to EED, especially for non-urgent pathologies. Potentially visual function threatening conditions, such as trauma-related pathologies, retinal detachment or ruptures, and wet AMD, showed lower number of cases but higher or stable proportion relative to the total caseload, suggesting a correct and efficient access to ophthalmic health care during the pandemic period.
Anterior chamber changes assessment by Scheimpflug analysis after intravitreal dexamethasone implantation
Authors: Kucukkomurcu Elvan , Sahin Tayfun 
Published: July 2021

Purpose: To evaluate structural changes in the anterior chamber and intraocular pressure (IOP) changes following intravitreal dexamethasone implantation. Methods: Forty-two eyes of 42 patients that received intravitreal dexamethasone implant for the management of macular edema secondary to diabetic retinopathy or branch retinal vein occlusion (BRVO) were included in the study. IOP was measured by Goldmann applanation tonometry. Anterior chamber depth (ACD) and iridocorneal angle (ICA) was measured by a Scheimflug camera (Sirius, CSO, Italy) the day before the injection of the dexamethasone implant and on postoperative day 1, first week, and first month. Results: Mean IOP was 15.14 ± 2.77 mmHg before the procedure and, 15.67 ± 3.70 mmHg, 15.86 ± 3.11 mmHg, 16.21 ± 2.75 mmHg on day 1, first week, and first month following intravitreal dexamethasone implantation, respectively. Mean ICA and ACD were significantly higher in pseudophakic eyes compared to phakic eyes. However, there was no statistically significant change in ICA before and after the procedure (on postoperative day 1, first week, and first month) among both phakic and pseudophakic patients ( p = 0.783). Similarly, ACD remained unchanged after the procedure (on postoperative day 1, first week, and first month) compared to the initial measurement ( p = 0.802). Conclusion: This study confirmed that there was an increase in IOP. However, these changes were not accompanied with a change in ACD or ICA.
Real-world effectiveness of vedolizumab in inflammatory bowel disease: week 52 results from the Swedish prospective multicentre SVEAH study
Authors: Eriksson Carl , Rundquist Sara , Lykiardopoulos Vyron , Udumyan Ruzan , Karlén Per , Grip Olof , Söderman Charlotte , Almer Sven , Hertervig Erik , Marsal Jan , Gunnarsson Jenny , Malmgren Carolina , Delin Jenny , Strid Hans , Sjöberg Mats , Öberg David , Bergemalm Daniel , Hjortswang Henrik , Halfvarson Jonas ,   The SWIBREG SVEAH Study Group
Published: July 2021

Background: Prospectively and systematically collected real-world data on vedolizumab are scarce. We aimed to assess the long-term clinical effectiveness of vedolizumab in inflammatory bowel disease (IBD). Methods: This study was a prospective, observational, multicentre study. Overall, 286 patients with active IBD were included (Crohn’s disease, n = 169; ulcerative colitis, n = 117). The primary outcomes were clinical response at week 12 and clinical remission at week 52, based on the Harvey Bradshaw Index and the partial Mayo Clinic score. Secondary outcomes included clinical remission at week 12, clinical response at week 52, corticosteroid-free clinical remission at week 52, changes in biochemical measures, and health-related quality of life (HRQoL). Results: At baseline, 88% of the patients were exposed to anti-TNF and 41% of the patients with Crohn’s disease had undergone ⩾1 surgical resection. At week 12, clinical response was 27% and remission 47% in Crohn’s disease; corresponding figures in ulcerative colitis were 52% and 34%. Clinical response, remission and corticosteroid-free remission at week 52 were 22%, 41% and 40% in Crohn’s disease and 49%, 47% and 46% in ulcerative colitis, respectively. A statistically significant decrease in median faecal-calprotectin and C-reactive protein was observed at 12 and 52 weeks in patients with Crohn’s disease and ulcerative colitis. The HRQoL measures Short Health Scale and EuroQol 5-Dimensions improved in both Crohn’s disease and ulcerative colitis patients ( p < 0.001). Clinical disease activity at baseline was inversely associated with clinical remission at week 52. Conclusion: Vedolizumab proved effective for the treatment of refractory IBD in clinical practice.
Quantitative Nanomechanical Mapping of Polyolefin Elastomer at Nanoscale with Atomic Force Microscopy
Authors: Zhang Shuting , Weng Yihui , Ma Chunhua 
Published: July 2021

AbstractElastomeric nanostructures are normally expected to fulfill an explicit mechanical role and therefore their mechanical properties are pivotal to affect material performance. Their versatile applications demand a thorough understanding of the mechanical properties. In particular, the time dependent mechanical response of low-density polyolefin (LDPE) has not been fully elucidated. Here, utilizing state-of-the-art PeakForce quantitative nanomechanical mapping jointly with force volume and fast force volume, the elastic moduli of LDPE samples were assessed in a time-dependent fashion. Specifically, the acquisition frequency was discretely changed four orders of magnitude from 0.1 up to 2 k Hz. Force data were fitted with a linearized DMT contact mechanics model considering surface adhesion force. Increased Young’s modulus was discovered with increasing acquisition frequency. It was measured 11.7 ± 5.2 MPa at 0.1 Hz and increased to 89.6 ± 17.3 MPa at 2 kHz. Moreover, creep compliance experiment showed that instantaneous elastic modulus E1, delayed elastic modulus E2, viscosity η, retardation time τ were 22.3 ± 3.5 MPa, 43.3 ± 4.8 MPa, 38.7 ± 5.6 MPa s and 0.89 ± 0.22 s, respectively. The multiparametric, multifunctional local probing of mechanical measurement along with exceptional high spatial resolution imaging open new opportunities for quantitative nanomechanical mapping of soft polymers, and can potentially be extended to biological systems.