bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving adherence to hepatitis B vaccine administration recommendations in two newborn nurseries
Authors: Germana Sarah , Krishnan Govind , McCulloch Matthew , Trinh Jane , Shaikh Sophie 
Published: October 2021

Administration of the birth dose of hepatitis B vaccine is an important step in reducing perinatally acquired hepatitis B infection, yet the USA is below the Healthy People 2020 goal for rate of administration.In response to updated Advisory Committee on Immunisation Practices recommendations to administer the dose within 24 hours of birth, we used quality improvement methodology to implement changes that would increase the vaccination rates of healthy newborns in our nurseries. The goal was to improve the proportion of infants who receive the hepatitis B vaccine within 24 hours of birth to >90% within a 2-year period, with a secondary goal of increasing vaccination rates prior to discharge from the nursery to >95%.Multiple Plan–Do–Study–Act (PDSA) cycles were performed. Initial cycles focused on increasing nurse and provider awareness of the updated timing recommendations. Later cycles targeted nursing workflow to facilitate timely administration of the vaccine. We implemented changes at our university medical centre and community hospital newborn nurseries.At the university medical centre nursery, both primary and secondary goals were met; the rate of hepatitis B vaccine administration within 24 hours increased from 81.7% to 96.2%, with vaccine administration prior to discharge increasing from 93.4% to 97.9%. In the community hospital nursery, the baseline rate of hepatitis B vaccine administration within 24 hours was 78.1%, and this increased to 85.8% with the interventions, falling short of the target of >90%. Vaccine administration prior to discharge increased from 87.2% to 92.0%, also not meeting the secondary target of 95%.Interventions that facilitated workflow had additional benefit beyond education alone to improve timing and rates of hepatitis B vaccine administration in both a university medical centre and community hospital nursery.
Health-related physical fitness in patients with complaints of hand, wrist, forearm and elbow: an exploratory study
Authors: Berduszek Redmar J , Geerdink Henk , van der Sluis Corry K , Reneman Michiel F , Dekker Rienk 
Published: October 2021

ObjectivesLittle is known about the physical fitness of patients with complaints of hand, wrist, forearm and/or elbow and its possible determinants. Aims were to assess health-related physical fitness (HRPF) in these patients, to compare HRPF with reference values of healthy persons, and to explore whether HRPF was correlated with symptom severity, upper limb function (ULF) and physical activity (PA).MethodsCardiorespiratory fitness, handgrip strength and body composition, self-reported symptom severity, ULF and PA were assessed in adult outpatients with complaints of hand, wrist, forearm and/or elbow diagnosed as CANS.ResultsMeasurements were completed in 25 subjects (8 males) aged 46.1±14.5 years, of which 44% had specific CANS and 56% had non-specific CANS.Peak oxygen consumption (VO2peak) of men was 2978±983 mL/min and of women was 1978±265 mL/min. Handgrip strength of men was 47.0±11.1 kgf and of women was 32.4±6.3 kgf. Body mass index (BMI) of men was 24.2±2.6 kg/m2and of women was 27.4±6.1 kg/m2.VO2peak of the study sample was lower than that of healthy adults (−414±510 mL/min, p<0.001). Handgrip strength and BMI were similar to reference values.VO2peak was correlated with PA (r=0.58, p=0.004); BMI was correlated with disability (r=0.48, p=0.022). Other correlations between HRPF and symptom severity and ULF were non-significant.ConclusionsPatients with CANS have lower cardiorespiratory fitness, but similar handgrip strength and body composition, compared with the healthy population. Cardiorespiratory fitness was correlated with PA and BMI was correlated with disability, no other correlations were observed with symptom severity and ULF.
Predicting cardiac adverse events in patients receiving immune checkpoint inhibitors: a machine learning approach
Authors: Heilbroner Samuel Peter , Few Reed , Neilan Tomas G , Mueller Judith , Chalwa Jitesh , Charest Francois , Suryadevara Somasekhar , Kratt Christine , Gomez-Caminero Andres , Dreyfus Brian 
Published: October 2021

BackgroundTreatment with immune checkpoint inhibitors (ICIs) has been associated with an increased rate of cardiac events. There are limited data on the risk factors that predict cardiac events in patients treated with ICIs. Therefore, we created a machine learning (ML) model to predict cardiac events in this at-risk population.MethodsWe leveraged the CancerLinQ database curated by the American Society of Clinical Oncology and applied an XGBoosted decision tree to predict cardiac events in patients taking programmed death receptor-1 (PD-1) or programmed death ligand-1 (PD-L1) therapy. All curated data from patients with non-small cell lung cancer, melanoma, and renal cell carcinoma, and who were prescribed PD-1/PD-L1 therapy between 2013 and 2019, were used for training, feature interpretation, and model performance evaluation. A total of 356 potential risk factors were included in the model, including elements of patient medical history, social history, vital signs, common laboratory tests, oncological history, medication history and PD-1/PD-L1-specific factors like PD-L1 tumor expression.ResultsOur study population consisted of 4960 patients treated with PD-1/PD-L1 therapy, of whom 418 had a cardiac event. The following were key predictors of cardiac events: increased age, corticosteroids, laboratory abnormalities and medications suggestive of a history of heart disease, the extremes of weight, a lower baseline or on-treatment percentage of lymphocytes, and a higher percentage of neutrophils. The final model predicted cardiac events with an area under the curve–receiver operating characteristic of 0.65 (95% CI 0.58 to 0.75). Using our model, we divided patients into low-risk and high-risk subgroups. At 100 days, the cumulative incidence of cardiac events was 3.3% in the low-risk group and 6.1% in the high-risk group (p<0.001).ConclusionsML can be used to predict cardiac events in patients taking PD-1/PD-L1 therapy. Cardiac risk was driven by immunological factors (eg, percentage of lymphocytes), oncological factors (eg, low weight), and a cardiac history.
Distinct mutational profile and immune microenvironment in microsatellite-unstable andPOLE-mutated tumors
Authors: Hwang Hee Sang , Kim Deokhoon , Choi Jene 
Published: October 2021

IntroductionMismatch repair (MMR)-deficient and DNA polymerase epsilon (POLE)-mutated tumors exhibit a high tumor mutation burden (TMB) and have been proven to be associated with good responses to immune checkpoint inhibitor treatments. However, the relationship between mutational characteristics of MMR-deficient andPOLE-mutated tumors and the spatial architecture of tumor-infiltrating lymphocytes (TILs) has not been fully evaluated.MethodsWe retrieved microsatellite instability-high (MSI-high, N=20) andPOLE-mutated (N=47) cases from the clinical next-generation sequencing cohort at Asan Medical Center. Whole-slide immunostaining for CD3, CD4, CD8, FoxP3 and PD-1 were performed with tissue samples of colorectal and gastric cancer (N=24) and the tumor-positive TIL cell densities were correlated with the tumor’s mutational features. The findings were compared with the results of similar analyses in The Cancer Genome Atlas-Colorectal Adenocarcinoma (TCGA-COADREAD) cohort (N=592).ResultsThe MSI-high group showed significantly higher overall TMBs with a number of insertion/deletion (indel) mutations relative to thePOLE-mutated group (median TMB; 83.6 vs 12.5/Mb). Oncogenic/likely-oncogenicPOLEmutations were identified with ultrahypermutations (≥100 mutations/Mb) (2/47, 4.3%). ConcurrentPOLEmutations of unknown significance and MSI-high cases were identified in eight cases (8/67, 11%), and two of these colorectal cancers had multiplePOLEmutations, showing an ultramutated phenotype (378.1 and 484.4/Mb) and low indel mutation burdens with complete loss of MSH-6 or PMS-2, which was similar to the mutational profile of thePOLE-inactivated tumors. Intratumoral CD3-positive, CD4-positive, CD8-positive, FoxP3-positive and PD-1-positive TIL cell densities were more strongly correlated with the indel mutation burden than with the total TMB (correlation coefficient, 0.61–0.73 vs 0.23–0.38). In addition, PI3K/AKT/mTOR pathway mutations were commonly found in MSI-high tumors (75%) but not inPOLE-mutated tumors.ConclusionsIndel mutation burden rather than total TMB could serve as a predictor of high TILs in both MSI-high andPOLE-mutated tumors. Multiple uncharacterized/non-pathogenicPOLEmutations occurring via MMR deficiency within MSI-high tumors may have combined pathogenic roles. A mutated PI3K/AKT/mTOR pathway may be a biomarker that can be used to stratify patients with advanced MSI-high tumors for immune therapy.
CXCR6 by increasing retention of memory CD8+ T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer
Authors: Muthuswamy Ravikumar , McGray AJ Robert , Battaglia Sebastiano , He Wenjun , Miliotto Anthony , Eppolito Cheryl , Matsuzaki Junko , Takemasa Tsuji , Koya Richard , Chodon Thinle , Lichty Brian D , Shrikant Protul , Odunsi Kunle 
Published: October 2021

PurposeResident memory CD8 T cells, owing to their ability to reside and persist in peripheral tissues, impart adaptive sentinel activity and amplify local immune response, and have beneficial implications for tumor surveillance and control. The current study aimed to clarify the less known chemotactic mechanisms that govern the localization, retention, and residency of memory CD8 T cells in the ovarian tumor microenvironment.Experimental designRNA and protein expressions of chemokine receptors in CD8+ resident memory T cells in human ovarian tumor-infiltrating CD8+ T cells and their association with survival were analyzed. The role of CXCR6 on antitumor T cells was investigated using prophylactic vaccine models in murine ovarian cancer.ResultsChemokine receptor profiling of CD8+CD103+ resident memory tumor-infiltrating lymphocytes in patients with ovarian cancer revealed high expression of CXCR6. Analysis of The Cancer Genome Atlas (TCGA) (ovarian cancer database revealed CXCR6 to be associated with CD103 and increased patient survival. Functional studies in mouse models of ovarian cancer revealed that CXCR6 is a marker of resident, but not circulatory, tumor-specific memory CD8+ T cells. CXCR6-deficient tumor-specific CD8+ T cells showed reduced retention in tumor tissues, leading to diminished resident memory responses and poor control of ovarian cancer.ConclusionsCXCR6, by promoting retention in tumor tissues, serves a critical role in resident memory T cell-mediated immunosurveillance and control of ovarian cancer. Future studies warrant exploiting CXCR6 to promote resident memory responses in cancers.
Adoptive cell therapy with tumor-infiltrating lymphocytes supported by checkpoint inhibition across multiple solid cancer types
Authors: Kverneland Anders Handrup , Chamberlain Christopher Aled , Borch Troels Holz , Nielsen Morten , Mørk Sofie Kirial , Kjeldsen Julie Westerlin , Lorentzen Cathrine Lund , Jørgensen Lise Pyndt , Riis Lene Buhl , Yde Christina Westmose , Met Özcan , Donia Marco , Marie Svane Inge 
Published: October 2021

BackgroundAdoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has shown remarkable results in malignant melanoma (MM), while studies on the potential in other cancer diagnoses are sparse. Further, the prospect of using checkpoint inhibitors (CPIs) to support TIL production and therapy remains to be explored.Study designTIL-based ACT with CPIs was evaluated in a clinical phase I/II trial. Ipilimumab (3 mg/kg) was administered prior to tumor resection and nivolumab (3 mg/kg, every 2 weeks ×4) in relation to TIL infusion. Preconditioning chemotherapy was given before TIL infusion and followed by low-dose (2 10e6 international units (UI) ×1 subcutaneous for 14 days) interleukin-2 stimulation.ResultsTwenty-five patients covering 10 different cancer diagnoses were treated with in vitro expanded TILs. Expansion of TILs was successful in 97% of recruited patients. Five patients had sizeable tumor regressions of 30%–63%, including two confirmed partial responses in patients with head-and-neck cancer and cholangiocarcinoma. Safety and feasibility were comparable to MM trials of ACT with the addition of expected CPI toxicity. In an exploratory analysis, tumor mutational burden and expression of the alpha-integrin CD103 (p=0.025) were associated with increased disease control. In vitro tumor reactivity was seen in both patients with an objective response and was associated with regressions in tumor size (p=0.028).ConclusionHigh success rates of TIL expansion were demonstrated across multiple solid cancers. TIL ACTs were found feasible, independent of previous therapy. Tumor regressions after ACT combined with CPIs were demonstrated in several cancer types supported by in vitro antitumor reactivity of the TILs.Trial registration numbersNCT03296137, and EudraCT No. 2017-002323-25.
Grain size and organic geochemistry of recent sediments in Lingding Bay, Pearl River Delta, China: implications for sediment dispersal and depositional processes perturbed by human activities
Authors: Yuan Xiuquan , Yang Qingshu , Meadows Michael E. , Luo Xiangxin , Wang Zhanghua 
Published: October 2021

Abstract
Lingding Bay (LDB), on the Pearl River Delta (PRD) of southern China, is a typical example of a large river mouth that is strongly affected by anthropogenic perturbations that have changed the boundary conditions of hydro- and sediment dynamic processes. An analysis of recent sedimentary patterns can shed light on the role of anthropogenic impacts on delta evolution. In this study, we collected surficial sediments from the LDB in December 2016 (dry season) and August 2017 (flood season) to analyze their grain size and organic geochemical compositions, with the aim of investigating recent depositional patterns in the bay and evaluating human impacts. The results reveal two major mud depocenters in the northeastern and southwestern parts of the bay, which are characterized by high values of grain-size end member 1 (EM1) and increased contributions of terrestrial organic carbon in the flood season. We propose that this sedimentary pattern is a manifestation of a system regime shift due to the strengthening of the fluvial function in fluvial-tide interactions and associated changes in the suspended sediment dispersal routine. We suggest that these changes are a result of recently intensified human activities, such as coastal land reclamation and sand mining. Coarsening of the surficial sediments in the LDB in the dry season and a marked increase in the terrestrial organic contribution at the mouth of the LDB indicates the redistribution of fine-grained sediments by waves and currents and increased mud export from the LDB in response to the shallowing of the bay.
Photocatalytic degradation of Eosin B dye in aqueous solution by cadmium oxide nanoparticles
Authors: Naz Falak , Saeed Khalid 
Published: October 2021

Cadmium oxide (CdO) and potassium (K) doped CdO nanoparticles (NPs) were synthesized by the chemical co-precipitation method and were used as photocatalysts for the degradation of Eosin B dye. The X-ray diffraction results presented that the crystallite size of undoped CdO and K doped CdO NPs were 43.74 and 42.31 nm, respectively. The morphological study and percent composition of synthesized undoped CdO and K doped CdO NPs was done by scanning electron microscope and energy dispersive X-ray analysis. The formation of NPs was confirmed by Fourier transform infrared spectroscopy. The precursor decomposition to CdO after annealing at ∼500 °C was studied by thermogravimetric analysis. The undoped CdO and K doped CdO nanoparticles degraded about 80% and 90% of the dye, respectively, in 140 min. The maximum degradation efficiency of the dye was achieved at a pH of 4, dye initial concentration of 15 ppm, catalyst dose of 20 mg, and a temperature of 45 °C. The degradation efficiency observed for recovered undoped CdO and recovered doped CdO nanoparticles was found to be 63% and 77%, respectively.
Predictive modeling to study lifestyle politics with Facebook likes
Authors: Praet Stiene , Van Aelst Peter , van Erkel Patrick , Van der Veeken Stephan , Martens David 
Published: October 2021

Abstract“Lifestyle politics” suggests that political and ideological opinions are strongly connected to our consumption choices, music and food taste, cultural preferences, and other aspects of our daily lives. With the growing political polarization this idea has become all the more relevant to a wide range of social scientists. Empirical research in this domain, however, is confronted with an impractical challenge; this type of detailed information on people’s lifestyle is very difficult to operationalize, and extremely time consuming and costly to query in a survey. A potential valuable alternative data source to capture these values and lifestyle choices is social media data. In this study, we explore the value of Facebook “like” data to complement traditional survey data to study lifestyle politics. We collect a unique dataset of Facebook likes and survey data of more than 6500 participants in Belgium, a fragmented multi-party system. Based on both types of data, we infer the political and ideological preference of our respondents. The results indicate that non-political Facebook likes are indicative of political preference and are useful to describe voters in terms of common interests, cultural preferences, and lifestyle features. This shows that social media data can be a valuable complement to traditional survey data to study lifestyle politics.
Antifungal Activity and Major Bioactive Compounds of Water Extract of Pangium edule Seed against Aspergillus flavus
Authors: Listyorini Kharisma I. , Kusumaningrum Harsi D. , Lioe Hanifah N. 
Published: October 2021

Pangium edule seeds are widely used as spices in Southeast Asia in a fresh and fermented form and are reported to have active compounds for food preservation. However, scientific data on the active compounds of P. edule seed that can prevent the growth of toxigenic Aspergillus flavus have not been widely reported. This research subjected to determine the antifungal activity and identify the active compounds of water extract of old and fermented seed of P. edule against A. flavus. The water extract was compared to the extracts obtained by multilevel maceration using 50% ethanol, ethyl acetate, and n-hexane as solvents. Alkaloid, saponin, phenolic compound, flavonoid, triterpenoid, and glycoside were detected qualitatively in the crude extracts. The water extract showed the best activity to suppress the growth of A. flavus, determined by the agar dilution method, with the minimum inhibitory concentration (MIC) of 12.5 and 25 mg/mL for old and fermented seed, respectively. The water extracts showed a moderate toxicity with LC50 of 100-500 μg/mL, determined by the brine-shrimp toxicity test. After fractionation using 3 kDa molecular-weight (MW) cut-off ultrafiltration membrane, two fractions, i.e., fraction with

MW
<
3

kDa and >3 kDa, were obtained. The fraction with

MW
<
3

kDa showed the best antifungal activity with the MIC of 6.25 and 12.5 mg/mL for old and fermented seed, respectively. LC-MS/MS profile showed that different compounds belong to fatty acid, amino acid, glycoside, and peptide were found as major active compounds in the fractionated water extract. The principal compounds and partial least-square analysis, however, suggested that fatty acid and glycoside are responsible for the antifungal activity. Hence, this study concluded that the water extract of P. edule seed had promising antifungal activity against A. flavus which was due to presence of particular compounds belong to fatty acid and glycoside.
Use of the AFX Stent Graft in Patients with Extremely Narrow Aortic Bifurcation: A Multicenter Retrospective Study
Authors: Wagenhäuser M. U. , Floros N. , Nikitina E. , Mulorz J. , Balzer K. M. , Goulas S. , Petrich M. , Dueppers P. , Simon F. , Schelzig H. , Oberhuber A. 
Published: October 2021

Introduction. This study analyzed the patient outcomes following endovascular aortic aneurysm repair (EVAR) for infrarenal aortic pathologies with very narrow aortic bifurcations using the AFX stent graft. Methods. The data was retrieved from the archived medical records of 35 patients treated for abdominal aortic aneurysm (AAA) (48.6%) or penetrating aortic ulcer (PAU) (51.4%) with very narrow aortic bifurcation between January 2013 and May 2020. Patient survival, freedom from endoleak (EL), and limb occlusion were estimated applying the Kaplan–Meier method. Results. The mean follow-up time was

20.4
±
22.8

months. The mean aortic bifurcation diameter was

15.8
±
2.2

mm

. Technical success was 100%, and no procedure-related deaths occurred. Two type II ELs occurred within 30-day follow-up. We observed one common iliac artery stenosis at four months and one type III EL at 54 months in the same patient, both of which required re-intervention. Overall patient survival was

95
±
5
%

(AAA: 100%; PAU:

89
±
10
%

), freedom from limb occlusion was

94
±
5
%

(AAA:

91
±
9
%

; PAU: 100%), freedom from type II EL was

94
±
4
%

(AAA:

88
±
8
%

; PAU: 100%), and freedom from EL type III was

83
±
15
%

(AAA:

80
±
18
%

; PAU: 100%) at the end of the follow-up period. Conclusions. Very narrow aortic bifurcations may predispose patients to procedure-related complications following EVAR. Our results suggest a safe use of the AFX stent graft in such scenarios. The overall short- and long-term procedure-related patient outcomes are satisfying albeit they may seem superior for PAU when compared to AAA.