bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refinement of matching costs for stereo disparities using recurrent neural networks
Authors: Emlek Alper , Peker Murat 
Published: April 2021

AbstractDepth is essential information for autonomous robotics applications that need environmental depth values. The depth could be acquired by finding the matching pixels between stereo image pairs. Depth information is an inference from a matching cost volume that is composed of the distances between the possible pixel points on the pre-aligned horizontal axis of stereo images. Most approaches use matching costs to identify matches between stereo images and obtain depth information. Recently, researchers have been using convolutional neural network-based solutions to handle this matching problem. In this paper, a novel method has been proposed for the refinement of matching costs by using recurrent neural networks. Our motivation is to enhance the depth values obtained from matching costs. For this purpose, to attain an enhanced disparity map by utilizing the sequential information of matching costs in the horizontal space, recurrent neural networks are used. Exploiting this sequential information, we aimed to determine the position of the correct matching point by using recurrent neural networks, as in the case of speech processing problems. We used existing stereo algorithms to obtain the initial matching costs and then improved the results by utilizing recurrent neural networks. The results are evaluated on the KITTI 2012 and KITTI 2015 datasets. The results show that the matching cost three-pixel error is decreased by an average of 14.5% in both datasets.
Depression in adults with sickle cell disease: a systematic review of the methodological issues in assessing prevalence of depression
Authors: Oudin Doglioni Damien , Chabasseur Vincent , Barbot Frédéric , Galactéros Frédéric , Gay Marie-Claire 
Published: April 2021

AbstractBackgroundSickle cell disease (SCD) as other chronic medical conditions is commonly complicated by depression or other psychiatric symptoms. Results reported in studies present a large variation. Thus, synthetic data are needed to understand impact of depression in adults with SCD. The aim of this literature review is to analyse the methodology used in the studies assessing depression and discuss the different prevalence levels reported.MethodsStudies involving adults with SCD from 1999 to 2018 were included when providing data on prevalence of depression. It was defined by a psychometric assessment, a structured interview, or a medical record review. PRISMA recommendations were followed.Results36 studies are included accordingly to our methodology. Prevalence variation is large, from 0% to more than 85%. We find that the type of assessment tool used plays a major role in this between studies variation. Also, methodological issues arise with respect to psychometric assessment. Moreover, differences emerge between continents, setting of recruitment or time of assessment.ConclusionAll these issues are discussed to provide insight on depression in adults with sickle cell disease.Trial RegistrationPROSPERO RegistrationCRD42018100684.
Biochar and vermicompost improve growth and physiological traits of eggplant (Solanum melongena L.) under deficit irrigation
Authors: Ebrahimi Mohsen , Souri Mohammad Kazem , Mousavi Amir , Sahebani Navazolah 
Published: April 2021

Abstract
Background
Drought is one of the most important environmental stresses that can adversely influence soil properties, plant growth, and productivity of agricultural crops including eggplant as an important vegetable crop. In recent years, the use of agricultural wastes has been reported as a beneficial and sustainable measure in soil water retention and fertility enhancement. In this study, the effect of date palm and pistachio biochar, vermicompost and a combination of biochar and vermicompost was evaluated on eggplant growth, yield and water use efficiency under deficit irrigation.

Materials and methods
The experiment was done in a split-split plot based on randomized complete block design with three replications and under open field conditions. The main plot was deficit irrigation in three levels of 100, 75 and 50% of plant water requirement (PWR), and the sub-plots were vermicompost in two levels of 0, 1500 g m−2, and biochar in three levels of 0, 500 g m−2 of the pistachio biochar and 500 g m−2 of the date palm biochar.

Results
The results showed that soil amendment with vermicompost and pistachio biochar and 100% PWR showed the best plant growth and performance. The early crop yield was highest under pistachio biochar and 50% PWR, while the total plant yield was highest under combined application of vermicompost and pistachio biochar at 100% PWR. The plant water use efficiency was maximum under mixed application of vermicompost and pistachio biochar at 50% PWR. Application of both pistachio biochar and vermicompost at 100% PWR resulted in the highest leaf concentrations of nitrogen, phosphorus, potassium, iron and manganese. The highest levels of physiologically important stress metabolites, including malondialdehyde, guaiacol peroxidase, superoxide dismutase and catalase enzymes were found in treatments without amendments or only with vermicompost and 50% PWR.

Conclusion
The results indicate that under normal and particularly water deficit conditions, vermicompost and biochar increased eggplant vegetative growth, yield and water use efficiency.
Triple metachronous primary pancreatic and gallbladder cancer associated with pancreaticobiliary maljunction: a case report
Authors: Kuhara Yuta , Hashimoto Yasushi , Hirahara Satoshi , Kubota Haruna , Shirakawa Kenji , Toyota Kazuhiro , Yano Raita , Kobayashi Hironori , Yokoyama Yujiro , Sakashita Yoshihiro , Murakami Yoshiaki , Taniyama Kiyomi , Miyamoto Katsunari 
Published: April 2021

Abstract
Background
Metachronous pancreatic and gallbladder cancer is a rare condition and has a dismal prognosis. Herein, we present a patient with triple metachronous primary pancreatic and gallbladder cancer associated with pancreaticobiliary maljunction who achieved long-term survival after undergoing repeat curative surgery.

Case presentation
A 65-year-old female patient with advanced gallbladder cancer associated with pancreaticobiliary maljunction underwent extended cholecystectomy with extrahepatic bile duct resection. The pathological diagnosis was T3N0M0 stage III A papillary adenocarcinoma with hepatic invasion. During a monthly follow-up, a diffuse hypovascular 2.0 × 1.5-cm mass was detected in the pancreatic head 6.2 years after the initial surgery. Hence, the patient underwent pancreaticoduodenectomy. Histological examination revealed T3N0M0 stage IIA well-differentiated adenocarcinoma without lymph node metastases. Marked inflammatory reaction was observed in the non-cancerous lesions of the proximal pancreatic head parenchyma containing bile pigment within ductular lumens. After 12.5 years from the initial surgery, total pancreatectomy for a 4.0 × 3.0-cm mass in the remnant pancreas was performed. Histological examination revealed T3N1M0 stage IIB moderately differentiated adenocarcinoma with lymph node metastases. Hence, surgical curative resection was achieved. Based on the pathological findings, a definitive diagnosis of triple metachronous pancreatic and gallbladder cancer was made. The pathology suggests no precursor lesions such as pancreatic intraepithelial neoplasia (PanIN) and atypical flat lesions, but marked inflammations in the non-cancerous lesions, strengthening our hypothesis that chronic inflammation induced by the pancreaticobiliary maljunction is related to carcinogenesis of the pancreas. Despite further adjuvant chemotherapy, the patient’s general condition worsened; however, she remained alive 15.2 years after the initial surgery while receiving the best supportive care.

Conclusions
Repeat curative surgery for triple metachronous cancer was associated with a favorable prognosis. Both the biliary tract and the pancreas should be closely monitored during follow-up among patients with pancreaticobiliary maljunction, which can be managed with curative surgery.
Comparing the effects of current circumcision techniques on dorsal root ganglia: an experimental study
Authors: Caglar Ozgur , Arslan Remzi , Firinci Binali , Aydin Muhammed Enes , Karadeniz Erdem , Nalci Kemal Alp , Salman Ahmet Bedii , Aydin Mehmet Dumlu 
Published: April 2021

AbstractBackgroundCircumcision is a surgical removal process of the preputium. Surgical excision and electric current cause neurodegeneration in the excised tissue-related neural network. This study investigates if circumcision and current surgical methods would cause histopathological changes in the penile tissue innervating pudendal nerve dorsal root ganglia.ResultsVascular congestion occluded the microvessels, and degenerative changes were detected in postexcised penile tissue. Neuronal angulation, cytoplasmic condensation, nuclear shrinkage, and condensed nuclei were observed in the pudendal nerve ganglia. Moreover, the degenerated neuron (DN) densities of the pudendal nerve ganglia were 5 ± 2, 98 ± 22, 1093 ± 185, 236 ± 43 and 151 ± 19 in the control, the surgical circumcision, the monopolar cautery, the bipolar cautery and the thermocautery groups, respectively.ConclusionsAlthough only the pudendal nerve endings are affected secondary to prepusium excision another pudendal axons can be damaged during bleeding control with cautery, the destruction of the neuron that sends this axon initiates a general inflammation in that ganglion. As a result, there may be a somatosensitive innervation defect in extrapenile tissues innervated by this ganglion. High-voltage electric devices should not be used unless obligatory.
The Randomized AMBORA Trial: Impact of Pharmacological/Pharmaceutical Care on Medication Safety and Patient-Reported Outcomes During Treatment With New Oral Anticancer Agents
Authors: Dürr Pauline , Schlichtig Katja , Kelz Carolin , Deutsch Birgit , Maas Renke , Eckart Michael J. , Wilke Jochen , Wagner Harald , Wolff Kerstin , Preuß Caroline , Brückl Valeska , Meidenbauer Norbert , Staerk Christian , Mayr Andreas , Fietkau Rainer , Goebell Peter J. , Kunath Frank , Beckmann Matthias W. , Mackensen Andreas , Neurath Markus F. , Pavel Marianne , Dörje Frank , Fromm Martin F. 
Published: April 2021

PURPOSEOral anticancer drugs (eg, kinase inhibitors) play an important role in cancer therapy. However, considerable challenges regarding medication safety of oral anticancer drugs have been reported. Randomized, controlled, multicenter studies on the impact of intensified clinical pharmacological/pharmaceutical care on patient safety and patient treatment perception are lacking.METHODSPatients were eligible for the randomized, multicenter AMBORA study, if they were newly started on any of the oral anticancer drugs approved in 2001 or later without restriction to certain tumor entities. Patients were randomly assigned to receive either standard of care (control group) or an additional, intensified clinical pharmacological/pharmaceutical care, which included medication management and structured patient counseling, over a period of 12 weeks (intervention group). Primary end points were the number of antitumor drug–related problems (ie, side effects and unresolved medication errors) and patient treatment satisfaction with the oral anticancer therapy after 12 weeks measured with the Treatment Satisfaction Questionnaire for Medication, category convenience.RESULTSTwo hundred two patients were included. Antitumor drug–related problems were significantly lower in the intervention compared with the control group (3.85 v 5.81 [mean], P < .001). Patient treatment satisfaction was higher in the intervention group (Treatment Satisfaction Questionnaire for Medication, convenience; 91.6 v 74.4 [mean], P < .001). The hazard ratio for the combined end point of severe side effects (Common Terminology Criteria for Adverse Events ≥ 3), treatment discontinuation, unscheduled hospital admission, and death was 0.48 (95% CI, 0.32 to 0.71, P < .001) in favor of the intervention group.CONCLUSIONTreatment with oral anticancer drugs is associated with a broad range of medication errors and side effects. An intensified clinical pharmacological/pharmaceutical care has considerable, positive effects on the number of medication errors, patient treatment perception, and severe side effects.
Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium
Authors: Gillessen Silke , Sauvé Nicolas , Collette Laurence , Daugaard Gedske , de Wit Ronald , Albany Costantine , Tryakin Alexey , Fizazi Karim , Stahl Olof , Gietema Jourik A. , De Giorgi Ugo , Cafferty Fay H. , Hansen Aaron R. , Tandstad Torgrim , Huddart Robert A. , Necchi Andrea , Sweeney Christopher J. , Garcia-Del-Muro Xavier , Heng Daniel Y. C. , Lorch Anja , Chovanec Michal , Winquist Eric , Grimison Peter , Feldman Darren R. , Terbuch Angelika , Hentrich Marcus , Bokemeyer Carsten , Negaard Helene , Fankhauser Christian , Shamash Jonathan , Vaughn David J. , Sternberg Cora N. , Heidenreich Axel , Beyer Jörg ,   for the International Germ Cell Cancer Classification Update Consortium
Published: April 2021

PURPOSEThe classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but relies on data of patients treated between 1975 and 1990.MATERIALS AND METHODSData on 9,728 men with metastatic nonseminomatous germ cell tumors treated with cisplatin- and etoposide-based first-line chemotherapy between 1990 and 2013 were collected from 30 institutions or collaborative groups in Europe, North America, and Australia. Clinical trial and registry data were included. Primary end points were progression-free survival (PFS) and overall survival (OS). The survival estimates were updated for the current era. Additionally, a novel prognostic model for PFS was developed in 3,542 patients with complete information on potentially relevant variables. The results were validated in an independent data set.RESULTSCompared with the original IGCCCG publication, 5-year PFS remained similar in patients with good prognosis with 89% (87%-91%) versus 90% (95% CI, 89 to 91), but the 5-year OS increased from 92% (90%-94%) to 96% (95%-96%). In patients with intermediate prognosis, PFS remained similar with 75% (71%-79%) versus 78% (76%-80%) and the OS increased from 80% (76%-84%) to 89% (88%-91%). In patients with poor prognosis, the PFS increased from 41% (95% CI, 35 to 47) to 54% (95% CI, 52 to 56) and the OS from 48% (95% CI, 42 to 54) to 67% (95% CI, 65 to 69). A more granular prognostic model was developed and independently validated. This model identified a new cutoff of lactate dehydrogenase at a 2.5 upper limit of normal and increasing age and presence of lung metastases as additional adverse prognostic factors. An online calculator is provided ( https://www.eortc.org/IGCCCG-Update ).CONCLUSIONThe IGCCCG Update model improves individual prognostication in metastatic nonseminomatous germ cell tumors. Increasing age and lung metastases add granularity to the original IGCCCG classification as adverse prognostic factors.
A Queer Romance
Authors: Newman Eric H. 
Published: April 2021

Abstract
This essay argues that the queer romances at the margins of Claude McKay’s Romance in Marseille operate as sites of possibility for a happy, egalitarian social relation that is longed for but not otherwise accessible in the novel. The essay contends that this novel, read against Home to Harlem (1928) and Banjo (1929), offers one of the most sustained, nuanced representations of queer life in McKay’s archive and in early twentieth-century LGBT literature more generally, one in which same-sex-oriented characters are rendered as normal, integral figures in urban life rather than as outré characters whose primary function is to add spice to the narrative. As the novel demonstrates the continuing appeal of queerness as a site for imagining a more liberated, loving form of social organization—one that relishes the pleasure-in-difference that is a hallmark of McKay’s writing—it also anticipates formations within the queer liberationist politics of the decades that followed.
Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches
Authors: Selvaraj Gurudeeban , Kaliamurthi Satyavani , Peslherbe Gilles H. , Wei Dong-Qing 
Published: April 2021

Background:Coronavirus (CoV) is an emerging human pathogen causing severe acute respiratory syndrome (SARS) around the world. Earlier identification of biomarkers for SARS can facilitate detection and reduce the mortality rate of the disease. Thus, by integrated network analysis and structural modeling approach, we aimed to explore the potential drug targets and the candidate drugs for coronavirus medicated SARS.Methods:Differentially expression (DE) analysis of CoV infected host genes (HGs) expression profiles was conducted by using the Limma. Highly integrated DE-CoV-HGs were selected to construct the protein-protein interaction (PPI) network. Results:Using the Walktrap algorithm highly interconnected modules include module 1 (202 nodes); module 2 (126 nodes) and module 3 (121 nodes) modules were retrieved from the PPI network. MYC, HDAC9, NCOA3, CEBPB, VEGFA, BCL3, SMAD3, SMURF1, KLHL12, CBL, ERBB4, and CRKL were identified as potential drug targets (PDTs), which are highly expressed in the human respiratory system after CoV infection. Functional terms growth factor receptor binding, c-type lectin receptor signaling, interleukin-1 mediated signaling, TAP dependent antigen processing and presentation of peptide antigen via MHC class I, stimulatory T cell receptor signaling, and innate immune response signaling pathways, signal transduction and cytokine immune signaling pathways were enriched in the modules. Protein-protein docking results demonstrated the strong binding affinity (-314.57 kcal/mol) of the ERBB4-3cLpro complex which was selected as a drug target. In addition, molecular dynamics simulations indicated the structural stability and flexibility of the ERBB4-3cLpro complex. Further, Wortmannin was proposed as a candidate drug to ERBB4 to control SARS-CoV-2 pathogenesis through inhibit receptor tyrosine kinase-dependent macropinocytosis, MAPK signaling, and NF-kb singling pathways that regulate host cell entry, replication, and modulation of the host immune system.Conclusion:We conclude that CoV drug target “ERBB4” and candidate drug “Wortmannin” provide insights on the possible personalized therapeutics for emerging COVID-19.
ROTEIRO DO FILME JOÃOSINHO DA GOMÉA - O REI DO CANDOMBLÉ (SEXTO TRATAMENTO)
Authors: Dutra Rodrigo Da Silva , Oliveira Janaina Santos 
Published: April 2021

Conhecer a história de pessoas que foram importantes para a constituição de um lugar é fundamental para construir um senso de pertencimento de um território. O curta documentário Joãosinho da Goméa - O Rei do Candomblé traz Seu João como o narrador de sua própria história, de sua vida em Inhambupe no estado do Bahia até sua chegada a Duque de Caxias onde fundou o Terreiro da Goméa Caxiense. A pesquisa para construção deste roteiro foi baseada em artigos acadêmicos, publicações e jornais da época. Apesar de ser uma personalidade conhecida, não encontramos em nossa pesquisa nenhum outro filme que contasse a sua história. A inspiração cinematográfica veio do filme Alma do Olho (1973) de Zózimo Bulbul, onde ele narrou a história da população negra na diáspora sem dizer uma palavra, com uma fotografia universal e atemporal. Assim foi construído o roteiro desta história que originou o documentário.
Nurse-led vetting of choose and book referrals into sub-specialty ear, nose and throat clinics
Authors: Davies Paul , Mirza Showkat 
Published: April 2021

Background/Aims The electronic ‘choose and book’ referral system can lead to patients being allocated to inappropriate ear, nose and throat sub-specialty clinics. Internal re-referrals to the more appropriate sub-specialty clinic is inefficient, leads to wasted appointments and is frustrating for both clinicians and patients. This study aimed to implement a nurse-led vetting system to ensure that new referrals were sent to the appropriate sub-specialty for their first appointment. Methods A team of three nurses were given guidelines and trained to assess GP referrals so that they could re-allocate inappropriate referrals to more appropriate sub-specialty ear, nose and throat clinics before their first appointment. The number of referrals that were re-allocated was calculated. Results Implementing a nurse-led vetting system of GP referrals led to 110/400 (28%) of cases being re-allocated to a more suitable sub-specialty clinic before initial consultation. The expertise of the nurse-led team was found to be sufficient, particularly when supplemented with additional training, to perform this task. Conclusions Nurse-led vetting of choose and book referrals is an efficient way of checking referrals to ensure that patients are sent to the appropriate clinic. This can increase the overall efficiency of the clinic and prevent the wasting of time and resources on inappropriate referrals.
#BrillantBeDient – Herausforderungen und Potenziale von Forschungsservices für dezentrale Forschung und Innovation im digitalen Raum
Authors: Lux Anna M. , Robra-Bissantz Susanne 
Published: April 2021

ZusammenfassungDigitale Services sind bereits Dreh- und Angelpunkt der Internetökonomie und bauen auf den Prinzipien von Interaktion, Zusammenarbeit und dem Wert individueller Unterstützung. Die Nutzung des Potenzials von digitalen Services ist in Praxisgebieten wie der Pflege, der Bildung und der Kinderbetreuung durch die Covid-19-Pandemie noch drängender geworden. Zur Schaffung von Innovationen in diesen Bereichen der personennahen Dienstleistungen, ist eine Zusammenarbeit von Wissenschaft und Praxis erforderlich. Doch die Mitwirkung in gängigen Kooperationsformen, wie z. B. Netzwerken, Technologieclustern oder Projekten, ist zunehmend von Dezentralität geprägt. Um im organisations- und standortübergreifenden Miteinander gemeinsame Ziele zu erreichen, bedarf es Unterstützungsleistungen. Der vorliegende Beitrag widmet sich den Herausforderungen und Potenzialen digitaler Forschungsservices dezentraler Forschung und Innovation. Dabei wird deutlich, dass die drei eingangs genannten Prinzipien nicht nur für die Internetökonomie von Bedeutung sind.