bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracranial Sonodynamic Therapy With 5-Aminolevulinic Acid and Sodium Fluorescein: Safety Study in a Porcine Model
Authors: Raspagliesi Luca , D’Ammando Antonio , Gionso Matteo , Sheybani Natasha D. , Lopes Maria-Beatriz , Moore David , Allen Steven , Gatesman Jeremy , Porto Edoardo , Timbie Kelsie , Franzini Andrea , Di Meco Francesco , Sheehan Jason , Xu Zhiyuan , Prada Francesco 
Published: June 2021

BackgroundSonodynamic therapy (SDT) is an emerging ultrasound-based treatment modality for malignant gliomas which combines ultrasound with sonosensitizers to produce a localized cytotoxic and modulatory effect. Tumor-specificity of the treatment is achieved by the selective extravasation and accumulation of sonosensitizers in the tumor-bearing regions. The aim of this study is to demonstrate the safety of low-intensity ultrasonic irradiation of healthy brain tissue after the administration of FDA-approved sonosensitizers used for SDT in experimental studies in an in vivo large animal model.MethodsIn vivo safety of fluorescein (Na-Fl)- and 5 aminolevulinic acid (5-ALA)-mediated low-intensity ultrasound irradiation of healthy brain parenchyma was assessed in two sets of four healthy swine brains, using the magnetic resonance imaging (MRI)-guided Insightec ExAblate 4000 220 kHz system. After administration of the sonosensitizers, a wide fronto-parietal craniotomy was performed in pig skulls to allow transmission of ultrasonic beams. Sonication was performed on different spots within the thalamus and periventricular white matter with continuous thermal monitoring. Sonication-related effects were investigated with MRI and histological analysis.ResultsPost-treatment MRI images acquired within one hour following the last sonication, on day one, and day seven did not visualize any sign of brain damage. On histopathology, no signs of necrosis or apoptosis attributable to the ultrasonic treatments were shown in target areas.ConclusionsThe results of the present study suggest that either Na-FL or 5-ALA-mediated sonodynamic therapies under MRI-guidance with the current acoustic parameters are safe towards healthy brain tissue in a large in vivo model. These results further support growing interest in clinical translation of sonodynamic therapy for intracranial gliomas and other brain tumors.
Photon Versus Proton Beam Therapy for T1–3 Squamous Cell Carcinoma of the Thoracic Esophagus Without Lymph Node Metastasis
Authors: Suh Yang-Gun , Bayasgalan Unurjargal , Kim Heung Tae , Lee Jong Mog , Kim Moon Soo , Lee Youngjoo , Lee Doo Yeul , Lee Sung Uk , Kim Tae Hyun , Moon Sung Ho 
Published: June 2021

Background and PurposeWe compared treatment outcomes and toxicities of photon radiotherapy versus proton beam therapy (PBT) and evaluated radiation field effects for T1–3 squamous cell carcinoma of the thoracic esophagus (EC) without lymph node metastasis.MethodsMedical records of 77 patients with T1–3N0M0 thoracic EC treated with radiotherapy between 2011 and 2019 were retrospectively analyzed. Among these patients, 61 (79.2%) individuals had T1 EC. The initial clinical target volume encompassed the whole esophagus with or without supraclavicular and/or abdominal lymph nodes (extended-field radiotherapy; 67 patients, 87.0%) or the area 3–5 cm craniocaudally and 1–2 cm radially from the gross tumor volume (involved-field radiotherapy; 10 patients, 13.0%). The final clinical target volume included margins of at least 1 cm from the gross tumor volume, with total radiation doses of 50–66 (median, 66) cobalt gray equivalent. Three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and PBT were used in twenty-four, five, and forty-eight patients, respectively. Concurrent chemotherapy was administered to 17 (22.0%) patients overall and only five (8.0%) T1 patients.ResultsPBT showed significantly lower lung and heart radiation exposure in mean dose, V5, V10, V20, and V30 than photon radiotherapy. The median follow-up for all patients was 46 (interquartile range, 22–72) months. The 5-year progression-free survival and overall survival rates were 56.5 and 64.9%, respectively, with no significant survival difference between photon radiotherapy and PBT. In patients with T1 EC, 5-year progression-free survival and overall survival rates were 62.6 and 73.5%, respectively.ConclusionsExtended-field radiotherapy using modern radiotherapy techniques without chemotherapy showed satisfactory clinical outcomes for lymph node-negative T1 EC.
Early IGF-1 Gene Therapy Prevented Oxidative Stress and Cognitive Deficits Induced by Traumatic Brain Injury
Authors: Montivero Agustín. J. , Ghersi Marisa. S. , Silvero C M. Jazmín , Artur de la Villarmois Emilce , Catalan-Figueroa Johanna , Herrera Macarena , Becerra María Cecilia , Hereñú Claudia. B. , Pérez Mariela. F. 
Published: June 2021

Traumatic Brain Injury (TBI) remains a leading cause of morbidity and mortality in adults under 40 years old. Once primary injury occurs after TBI, neuroinflammation and oxidative stress (OS) are triggered, contributing to the development of many TBI-induced neurological deficits, and reducing the probability of critical trauma patients´ survival. Regardless the research investment on the development of anti-inflammatory and neuroprotective treatments, most pre-clinical studies have failed to report significant effects, probably because of the limited blood brain barrier permeability of no-steroidal or steroidal anti-inflammatory drugs. Lately, neurotrophic factors, such as the insulin-like growth factor 1 (IGF-1), are considered attractive therapeutic alternatives for diverse neurological pathologies, as they are neuromodulators linked to neuroprotection and anti-inflammatory effects. Considering this background, the aim of the present investigation is to test early IGF-1 gene therapy in both OS markers and cognitive deficits induced by TBI. Male Wistar rats were injected via Cisterna Magna with recombinant adenoviral vectors containing the IGF-1 gene cDNA 15 min post-TBI. Animals were sacrificed after 60 min, 24 h or 7 days to study the advanced oxidation protein products (AOPP) and malondialdehyde (MDA) levels, to recognize the protein oxidation damage and lipid peroxidation respectively, in the TBI neighboring brain areas. Cognitive deficits were assessed by evaluating working memory 7 days after TBI. The results reported significant increases of AOPP and MDA levels at 60 min, 24 h, and 7 days after TBI in the prefrontal cortex, motor cortex and hippocampus. In addition, at day 7, TBI also reduced working memory performance. Interestingly, AOPP, and MDA levels in the studied brain areas were significantly reduced after IGF-1 gene therapy that in turn prevented cognitive deficits, restoring TBI-animals working memory performance to similar values regarding control. In conclusion, early IGF-1 gene therapy could be considered a novel therapeutic approach to targeting neuroinflammation as well as to preventing some behavioral deficits related to TBI.
Challenge Accepted! a Critical Reflection on How to Perform a Health Survey Among University Students—An Example of the Healthy Campus Mainz Project
Authors: Reichel Jennifer L. , Rigotti Thomas , Tibubos Ana Nanette , Werner Antonia M. , Schäfer Markus , Edelmann Dennis , Pfirrmann Daniel , Deci Nicole , Beutel Manfred E. , Stark Birgit , Simon Perikles , Letzel Stephan , Dietz Pavel 
Published: June 2021

Background: Universities represent an important setting of everyday life for health promotion. The Healthy Campus Mainz project aims to develop an evidence-based and comprehensive student health management program covering physical, mental, and social health promotion. Hence, an initial health survey was performed in order to identify the students' health concerns and resources. Up until now, it remains unclear which topics to choose in a health survey among university students and which strategies can be recommended to receive an acceptable response rate or representative student sample within a university setting. The present paper contributes to the call for the present research topic “Public Health Promotion in University Students” by describing methods for health assessment. Therefore, the current paper aims to give an empirical example on how to perform a health survey among university students, focusing on (1) choosing topics for the survey and (2) methodological considerations of how to reach the target population.Methods: An online questionnaire including around 270 items was developed covering a comprehensive set of health topics. Participants were recruited via the university email. Mixed channels for survey promotion, such as lecture visits and social media, were used, accompanied by different monetary and non-monetary incentives. Descriptive analyses were performed to describe the sample.Results: A total of 5,006 participants (out of 31,213 registered students) viewed the first page of the questionnaire; of whom, 4,714 continued further. After a manual data cleaning according to the predefined criteria, the final sample was 4,351, demonstrating a response rate of 13.9%. Students from different study disciplines participated. However, some study disciplines showed a low participation rate, hence, making the results not free from some bias.Discussion: This survey is exceptional as it integrates a great variety of health aspects. The incentive strategy demonstrated promising results. Future research should try to improve target-group-specific recruitment strategies for the traditionally underrepresented groups, such as males and specific study disciplines. This would not only include advancing marketing strategies, but also refining the incentive strategy.
LenSelect: Object Selection in Virtual Environments by Dynamic Object Scaling
Authors: Weller Rene , Wegele Waldemar , Schröder Christoph , Zachmann Gabriel 
Published: June 2021

AbstractWe present a novel selection technique for VR called LenSelect. The main idea is to decrease the Index of Difficulty (ID) according to Fitts’ Law by dynamically increasing the size of the potentially selectable objects. This facilitates the selection process especially in cases of small, distant or partly occluded objects, but also for moving targets. In order to evaluate our method, we have defined a set of test scenarios that covers a broad range of use cases, in contrast to often used simpler scenes. Our test scenarios include practically relevant scenarios with realistic objects but also synthetic scenes, all of which are available for download. We have evaluated our method in a user study and compared the results to two state-of-the-art selection techniques and the standard ray-based selection. Our results show that LenSelect performs similar to the fastest method, which is ray-based selection, while significantly reducing the error rate by 44%.
INFORMATION SYSTEM DEVELOPMENT «TEACHER’S PERSONAL OFFICE»
Authors: Алисултанова Э.Д. , Бериев И.Р. , Сулейманов А.С. 
Published: June 2021

В данной статье рассматривается проблема работы научно-педагогического работника, связанной с организацией и планированием контактной учебной работы, заполнением и актуализацией рабочих программ дисциплин, расписанием лекций, семинаров, лабораторных работ, экзаменов, зачетов, а также с заполнением и представлением различных форм отчетности. Важным фактором, определяющим необходимость разработки информационной системы, является отсутствие на рынке программного продукта, позволяющего использовать его в качестве решения проблемы. В ходе исследования проведены: анализ работы научно-педагогического сотрудника Грозненского государственного нефтяного технического университета имени академика М.Д. Миллионщикова анализ существующих систем автоматизированного рабочего места преподавателя анализ программного и технического обеспечения. В результате исследования разработана информационная система Личный кабинет преподавателя , которая предоставит возможность преподавателям учебного заведения упростить учебную работу, а также сократит количество бумажных форм, поскольку вся необходимая информация будет храниться в системе.
This article discusses the problem of the work of a scientific and pedagogical worker related to the organization and planning of contact academic work, filling and updating work programs of disciplines, the schedule of lectures, seminars, laboratory works, exams, tests, and also filling and presenting various forms of reporting. An important factor determining the need to develop an information system is the lack of a software product on the market that allows it to be used as a solution to a problem. During the study: analysis of the work of the scientific and pedagogical employee of the Grozny State Oil Technical University named after academician M.D. Millionschikov analysis of existing systems of a teachers workstation analysis of software and hardware. As a result of the study, an information system Teachers Personal Account was developed, which will provide teachers of the educational institution with the opportunity to simplify their work and reduce the number of paper forms, since all the necessary information will be stored in the system.
MIMO TECHNOLOGY AS A BACKGROUND OF 5G NETWORK DEVELOPMENT
Authors: Таймасханова Х.Э. , Элиханова М.Ш. , Хаджиева Л.К. 
Published: June 2021

В статье определены особенности развития технологии MIMO в сетях 5G и рассмотрено их применение на практике. Также приведены имеющиеся на данный момент данные о применении технологии MIMOв сетях 5G. Рассмотрены проблемы реализации технологии MIMOи их решение. Определена роль данной технологии в будущем беспроводных коммуникаций. Возрастающие темпы развития телекоммуникаций и радикальные изменения потребностей и ожиданий абонентов сетей сотовой связи вновь и вновь диктуют развитие с последующей сменой технологических партнеров. Мобильные устройства перестали быть просто средством коммуникации, они стали умным инструментом информационного потребления, расширяя возможности человека. Процессы, такие как повсеместное распространение смартфонов и планшетов, разработка облачных сервисов и социальных сетей, резко изменили привычки и поведение пользователей. Сегодня мобильные абоненты ожидают от беспроводных сетей те же, если не больше, возможности как от проводного интернета. Основные доходы мобильных операторов все чаще поступают от голосовых услуг к услугам передачи данных.
The article defines the features of the development of MIMO technology in 5G networks and considers their application in practice. The data currently available on the use of MIMO technology in 5G networks are also presented. The problems of the implementation of MIMO technology and their solution are considered. The role of this technology in the future of wireless communications is determined. The increasing pace of telecommunications development and the radical changes in the needs and expectations of subscribers of cellular networks again and again dictate development with the subsequent change of technological partners. Mobile devices have ceased to be just a means of communication, they have become a smart tool for information consumption, expanding human capabilities. Processes, such as the ubiquity of smartphones Вестник ГГНТУ. Технические науки, том XV, 4 (18), 2019 26 and tablets, the development of cloud services and social networks, have dramatically changed user habits and behavior. Today, mobile subscribers expect the same, if not more, capabilities from wireless networks as from wired Internet. The main income of mobile operators is increasingly coming from voice services to data services.
Manajemen Intervensi HOT FLUSH dengan Menggunakan BodyWipe
Authors: Bina Aquari  
Published: June 2021

Gejala paling umum yang dialami wanita menopause, yaitu hot flush. Hot Flush adalah perasaan panas yang muncul mulai dari bagian atas tubuh dan menyebar ke wajah. Intervensi yang dilakukan untuk mendinginkan hot flush dengan menggunakan body wipe. Body Wipe adalah alat penyeka tubuh yang memberikan kesegaran. Penelitian ini bertujuan untuk mengetahui pengaruh body wipe sebagai manajemen intervensi hot flush pada wanita menopause di Klinik/BP Anisa. Penelitian ini merupakan eksperimen dengan menggunakan rancangan eksperimen semu. Data diperoleh dengan kuisioner untuk karakteristik umur, pendidikan dan pekerjaan sedangkan observasi untuk suhu sebelum dan sesudah diberi manajemen intervensi body wipe. Sampel penelitian ini adalah wanita menopause berjumlah 12 orang yang berkunjung untuk berobat di Klinik/BP Anisa. Metode analisis data menggunakan uji statistik wilcoxon. Analisis Univariat menunjukan suhu tinggi pada suhu sebelum diberi manajemen intervensi body wipe (100%), sesudah diberi manajemen intervensi body wipe suhu normal (91.7%) dan suhu tinggi (8.3%), umur fase menopause (100%), pendidikan bawah (100%), pekerjaan secara mandiri (100%). Untuk analisis bivariat terdapat 12 wanita menopause (100%) dengan hasil suhu inti tubuh lebih rendah setelah diberi manajemen intervensi body wipe dibandingkan sebelum diberi manajemen intervensi body wipe. Hasil penelitian ini menunjukan bahwa manajemen intervensi dengan menggunakan body wipe dapat berpengaruh dalam mengatasi hot flush pada ibu menopause di Klinik/BP Anisa dengan nilai nilai p= 0,001. Body wipe dapat digunakan sebagai manajemen intervensi untuk mengatasi hot flush.
Perspektif Kemudahan Akses Lokasi dengan Kepuasan Pasien UPTD Puskesmas Sekar Jaya Tahun 2020
Authors: Febrianti Gusparini  
Published: June 2021

Kemudahan akses menuju lokasi puskesmas merupakan salah satu kriteria pasien dalam memilih pelayanan kesehatan yang dibutuhkan. Pada masa sekarang ini dimana pembangunan dan perkembangan transportasi, teknologi dan penerapan pelayanan on line sangat memudahkan bagi masyarakat untuk memilih tempat pelayanan kesehatan yang diinginkan. Penelitian ini menilai Perspektif kemudahan akses ke lokasi puskesmas dengan kepuasan pasien yang menerima pelayanan di UPTD Puskesmas Sekar Jaya tahun 2020 dengan desain Penelitian analitik dengan dengan desain cross sectional dan dengan menggunakan dua instrumen penelitian yaitu quesioner kemudahan akses dan quesioner kepuasan pelanggan pada tanggal 1 Nopember sampai dengan 1 Desember 2020 dengan jumlah sampel 80 sampel. Dalam menganalisa hasil penelitian , peneliti menggunakan uji Chi – Square dan didapatkan hasil bahwa kemudahan dalam mencapai lokasi (geografis), Aksesbilitas transportsi umum dan ketersediaan lahan parkir yang memadai memiliku hubungan yang bermakna pada kepuasan pasien.
IMPLIKASI YURIDIS PASAL 46 UU NO 44 THN 2009 TENTANG RUMAH SAKIT TERHADAP KELALAIAN YANG DILAKUKAN TENAGA KESEHATAN DALAM HAL INI TENAGA MEDIS
Authors: Mingkid Billy Imanuel 
Published: June 2021

Tujuan dilakukannya penelitian yaitu untuk mengetahui apakah rumah sakit sepenuhnya bertanggung jawab atas kelalaian yang dilakukan tenaga kesehatan dan dalam hal apa tenaga medis selaku staf di rumah sakit bertanggung jawab atas kelalaian yang dilakukannya, yang dengan metpde penelitian hukum normatif disimpulkan: Hubungan antara rumah sakit-dokter-pasien adalah berdasarkan hubungan terapeutik yang dimana melahirkan hak dan kewajiban dari para pihak. Pada pasal 46 Undang-Undang Nomor 44 Tahun 2009 tentang Rumah Sakit dapat ditafsirkan bahwa rumah sakit dapat bertanggungjawab terhadap kelalaian tenaga kesehatan, Rumah Sakit dapat bertanggung jawab terhadap kerugian akibat dari kelalaian, Rumah Sakit tidak bertanggung jawab jika terbukti tidak adanya kelalaian yang dilakukan tenaga kesehatan, Rumah Sakit tidak bertanggung jawab terhadap tindakan kesengajaan tenaga kesehatan yang menimbulkan kerugian seseorang, Rumah Sakit tidak bertanggung jawab terhadap kelalaian akibat tindakan medis yang dilakukan tenaga medis yang bukan pegawainya, Tenaga Medis dapat bertanggung jawab terhadap kerugian yang ditimbulkan akibat dari kelalaian yang dilakukannya.Kata kunci: rumah sakit; tenaga kesehatan
ANALISIS YURIDIS PENGATURAN BATAS LAUT WILAYAH ANTARA INDONESIA (BATAM) DAN SINGAPURA MENURUT UNDANG-UNDANG NOMOR 43 TAHUN 2008 TENTANG WILAYAH NEGARA
Authors: Lamionda David Reagan Paulus 
Published: June 2021

Tujuan penelitian ini untuk mengetahui bagaimanakah Pengaturan Batas Laut Wilayah Antara Indonesia (Batam) Dan Singapura Menurut Undang-Undang Nomor 43 Tahun 2008 Tentang Wilayah Negara dan bagaimanakah Penyelesaian Batas Laut Wilayah Antara Indonesia (Batam) Dan Singapura Menurut Undang-Undang Nomor 43 Tahun 2008 Tentang Wilayah Negara, yang dengan metode penelitian hukum normatif disimpulkan: 1. Sebagaimana di atur dalam Undang-undang nomor 7 tahun 1973 tentang perjanjian batas laut wilayah Indonesia (Batam) dan Singapura yang selanjutnya diperbarui dengan Undang-Undang No 4 Tahun 2010 tentang Pengesahan Perjanjian Antara Rupublik Singapura Tentang Penetapan Garis Batas Selat Singapura,2009, mengingat Undang-Undang Nomor 43 tahun 2008 Tentang Wilayah Negara sebagian lagi diatur melalui perjanjian-perjanjian atau treaty antara indonesia dengan negara tetangga seperti Singapura .perjanjian-perjanjian atau traktat/treaty itu yang menjadi dasar dalam penetapan batas wilayah negara kesatuan Republik Indonesia serta Indonesia memiliki kewajiban untuk menetapkan batas maritimnya melalui pengaturan yang sesuai dengan konvensi Hukum Laut (UNCLOS) Pengaturan yang di sepakati yaitu Segmen bagian barat Di Wilayah Pulau Nipa-Tuas, segmen bagian timur 1 di Wilayah pulau Batam-Changi dan segmen bagian timur 2 di Wilayah pulau Bintan-South. Dengan adanya kepastian dan kejelasan garis batas laut wilayah antara Indonesia dan Singapura di selat Singapura ,maka segala tantangan dan permasalahan yang kerap kali muncul dan di hadapi dapat diantisipasi dan diatasi oleh aparat yang berwenang di kedua negara, selain itu, kedua negara juga dapat lebih leluasa dalam malanjutkan dan bahkan, meningkatkan kerja sama di bidang keselamatan pelayaran, perlindungan lingkungan laut dan penanggulangan kejahatan lintas batas di perairan perbatasan tersebut. 2. Dalam penyelesaian batas wilayah laut ini , Indonesia dan Singapura berhasil menandatangani perjanjian Bilateral kedua negara ini tentang penetapan garis batas laut di selat Singapura perjanjian Bilateral ini diundangkan sebagai Undang-Undang Nomor 7 Tahun 1973. ada enam titik koordinat yang ditarik dari bagian barat sehingga bagian timur selat Singapura. batas wilayah laut ini jelas akan membantu tugas-tugas TNI AL untuk mengamankan selat malaka dan kedaulatan perairan Indonesia. sebelumnya, perbatasan laut antara Indonesia dan Singapura ini tidaklah jelas batas-batasnya, sehingga pengamanan wilayah laut di kawasan perbatasan laut itu hanya dilakukan atas dasar perkiraan. dengan perjanjian ini, memungkinkan pihak TNI AL akan bertindak lebih tegas terhadap kegiatan kejahatan di laut.Kata kunci: wilayah negara; batas laut wilayah