bluuebunny/crossref_metadata_2025_split huggingface dataset:
Where the Spirit Dwells: Reflections on “The Encyclical of the Recent Holy and Great Council of the Orthodox Church” through an Eastern-European Pentecostal Lens
Authors: Augustine Daniela Christova 
Published: May 2021

ABSTRACT
The present article looks at the Encyclical of the Holy and Great Council of the Orthodox Church (Crete, 2016) and its implications for ecumenical relations between Orthodox and Classical Pentecostals. The text reflects on the Encyclical through an Eastern-European Pentecostal perspective, engaging its inherent ecclesiological pneumatology, by focusing on three interrelated themes, namely, the understanding of the church as a continuing Pentecost, the apostolic succession as a guardian of the church’s charismatic essence, and the church’s sobornost—its pneumatic conciliarity and catholicity.
Holy Council Ecumenical Responses: An Orthodox “Snapshot” Reflection in Time
Authors: FitzGerald Kyriaki Karidoyanes 
Published: May 2021

ABSTRACT
The editors of the Journal of World Christianity invited the author to offer an Orthodox reply to four ecumenical responses (Catholic and Protestant) to the historic 2016 Holy and Great Council held on the island of Crete. Written from both a theological and phenomenological perspective, this evaluation serves as a “snapshot in time” regarding the unprecedented significance of this extraordinary event. Furthermore, responses called attention to some major issues that diverse groups of Christians are facing today, vis-à-vis one another, and especially regarding the Orthodox Church.
Louis Jacobs, Revelation, and the Ongoing Battle to Defend Jewish Orthodoxy
Authors: Freud-Kandel Miri 
Published: May 2021

Louis Jacobs, (1920-2006), a British scholar-rabbi, became embroiled in the so-called “Jacobs Affair” in the 1960s, a controversy generally associated with his views on divine revelation. Influenced by his encounter with academic biblical scholarship, Jacobs tried to construct an apologetic account of how to maintain belief in Torah min Hashamayim— Torah from Heaven — while addressing secularist challenges to these teachings. Highlighting divisions between more conservative and liberal currents within Orthodox Judaism, Jacobs was effectively ostracised from British Orthodoxy for his efforts. Yet the challenge he sought to address has not gone away. Instead, there is growing engagement with the issue, with the internet increasingly influencing the contours and content of this debate. The questions directed at the dogmatic accounts of revelation promulgated within Orthodoxy form part of a broader challenge to religious authority. A study of Jacobs’ position, alongside some more contemporary arguments developed in a post-secular context, offers a framework for considering the varied apologetic Jewish responses that have been formulated to defend divine teachings against secularist critiques.
Absenteeism-illness of education servers: profile of sick leaves in a federal institution
Authors: Figueiredo Bárbara de Oliveira , Silva Luiz Sérgio , Colodette Renata Maria , Pereira Luiza Possa , Silva Larissa Bruna Bhering , Oliveira Deíse Moura de , Moreira Tiago Ricardo 
Published: May 2021

Investigated the factors associated to the number of days of sick leave of federal civil servants in an educational institution and the values of their occupational indices in the period from 2014 to 2017. Data sociodemographic, occupational and sick leaves were obtained through documentary analysis of medical records and administrative systems. For analysis, we used the absolute and relative frequency and multiple linear regression. Calculated rate of absenteeism-illness, frequency index, severity index and the average duration of leaves, stratified by gender and job role. The sample of 5,115 events in the population of 1,104 servers confirmed the positive relationship between age of the server, the level of schooling of the role and mental and behavioral disorders with the largest number of days of leaves. The female gender, live in the city where works, servers those did not have information on the marital status, technical-administrative job role and the public service time proved to be associated with fewer days of leave. The results presented show the relevance of absenteeism-illness in the context of federal public education and indicate the needs of interference in this sector regarding the organization of work and the health-disease process of their servers.
Caracterização do relevo do município de Santiago - RS com apoio de SIG
Authors: Gaberti Marinéli Moraes , Robaina Luis Eduardo de Souza , Trentin Romario , Chavez Marizete Palhano 
Published: May 2021

O presente estudo, realizado no município de Santiago, que se localiza na região Centro-Oeste do Rio Grande do Sul, tem como objetivo caracterizar o relevo identificando atributos topográficos obtidos de um Modelo Digital do Terreno (MDT) utilizando ferramentas de geotecnologias e SIG. Determinou-se três níveis de classificação definidos por formas de relevo, elementos de relevo e forma das vertentes. As formas indicam um conjunto de parcelas relativamente homogênea representado por áreas planas, colinas, morros e morrotes, sendo calculadas por análise da declividade e amplitude. Os elementos do relevo classificados em 10 formas básicas são identificados a partir da técnica dos geomorphons baseada na similaridade textural do modelo digital, que é transferido para valores de elevação do terreno, a distância e o ângulo de direção dos pontos vizinhos em relação a célula central. A forma das vertentes definidas como unidades geomorfométricas foram compartimentadas a partir do emprego de três variáveis geomorfométricas: declividade, perfil de curvatura e plano de curvatura. As formas mais importantes são de colinas levemente onduladas, onde se destacam os elementos de vertente, topos e vales largos. As vertentes predominantes são a do tipo I e VIII, sendo que a I apresenta declividade superior a 5%, convergente e côncava e a vertente do tipo VIII apresenta declividade inferiores a 5%, divergente e convexa.
Editorial
Authors: Tondo Rômulo Oliveira 
Published: May 2021

Centro de Ciências Sociais e Humanas (CCSH), da Universidade Federal de Santa Maria (UFSM), apresenta a comunidade acadêmica a primeira edição da RSH do ano de 2021. Na esperança que todos se encontrem bem e com a saúde em dia! Nesta Edição da Revista Sociais e Humanas, periódico vinculado ao estaremos ofertando aos leitores um leque amplo de temas e estudos. Manifestamos que somos inteiramente gratos a todos os autores, pareceristas e leitores que, respectivamente, engrandecem o conteúdo e a qualidade científica da Revista. Deste modo, desejamos a todos uma fluida e profícua leitura.
Photoacoustic lymphangiography before and after lymphaticovenular anastomosis
Authors: Oh Anna , Kajita Hiroki , Matoba Eri , Okabe Keisuke , Sakuma Hisashi , Imanishi Nobuaki , Takatsume Yoshifumi , Kono Hikaru , Asao Yasufumi , Yagi Takayuki , Aiso Sadakazu , Kishi Kazuo 
Published: May 2021

Background
Lymphaticovenular anastomosis (LVA) is a minimally invasive surgical procedure used to treat lymphedema. Volumetric measurements and quality-of-life assessments are often performed to assess the effectiveness of LVA, but there is no method that provides information regarding postoperative morphological changes in lymphatic vessels and veins after LVA. Photoacoustic lymphangiography (PAL) is an optical imaging technique that visualizes the distribution of light-absorbing molecules, such as hemoglobin or indocyanine green (ICG), and provides three-dimensional images of superficial lymphatic vessels and the venous system simultaneously. In this study, we performed PAL in lymphedema patients before and after LVA and compared the images to evaluate the effect of LVA.
Methods
PAL was performed using the PAI-05 system in three patients (one man, two women) with lymphedema, including one primary case and two secondary cases, before LVA. ICG fluorescence lymphography was performed in all cases before PAL. Follow-up PAL was performed between 5 days and 5 months after LVA.
Results
PAL enabled the simultaneous visualization of clear lymphatic vessels that could not be accurately seen with ICG fluorescence lymphography and veins. We were also able to observe and analyze morphological changes such as the width and the number of lymphatic vessels and veins during the follow-up PAL after LVA.
Conclusions
By comparing preoperative and postoperative PAL images, it was possible to analyze the morphological changes in lymphatic vessels and veins that occurred after LVA. Our study suggests that PAL would be useful when assessing the effect of LVA surgery.
AraCust: a Saudi Telecom Tweets corpus for sentiment analysis
Authors: Almuqren Latifah , Cristea Alexandra 
Published: May 2021

Comparing Arabic to other languages, Arabic lacks large corpora for Natural Language Processing (Assiri, Emam & Al-Dossari, 2018; Gamal et al., 2019). A number of scholars depended on translation from one language to another to construct their corpus (Rushdi-Saleh et al., 2011). This paper presents how we have constructed, cleaned, pre-processed, and annotated our 20,0000 Gold Standard Corpus (GSC) AraCust, the first Telecom GSC for Arabic Sentiment Analysis (ASA) for Dialectal Arabic (DA). AraCust contains Saudi dialect tweets, processed from a self-collected Arabic tweets dataset and has been annotated for sentiment analysis, i.e.,manually labelled (k=0.60). In addition, we have illustrated AraCust’s power, by performing an exploratory data analysis, to analyse the features that were sourced from the nature of our corpus, to assist with choosing the right ASA methods for it. To evaluate our Golden Standard corpus AraCust, we have first applied a simple experiment, using a supervised classifier, to offer benchmark outcomes for forthcoming works. In addition, we have applied the same supervised classifier on a publicly available Arabic dataset created from Twitter, ASTD (Nabil, Aly & Atiya, 2015). The result shows that our dataset AraCust outperforms the ASTD result with 91% accuracy and 89% F1avg score. The AraCust corpus will be released, together with code useful for its exploration, via GitHub as a part of this submission.
Seminar-case learning model improves clinical teaching: a prospective randomized controlled trial
Authors: Li Peiyuan , Zeng Bin , Chen Xuanmin , Liu Zhifeng , Yang Jing 
Published: May 2021

Purpose
The purpose of this research was to assess whether the efficacy of the seminar-case learning model is superior to the traditional lecture-based learning model in the gastroenterology curriculum for first-year graduate students.

Materials & Methods
This research was a prospective randomized controlled trial that enrolled 92 first-year postgraduate students with a rotation internship in the gastroenterology department. The students were randomly divided into 2 groups and then subjected to an identical version of the curriculum for 8 weeks. The experimental group (n = 50) used the seminar-case learning model, while the control group (n = 42) used the traditional lecture-based learning model. Examinations consisted of a theoretical test and a case analysis test, and anonymous questionnaires were used to assess teaching quality.

Results
All participants completed the examinations and questionnaires. The average theoretical test score of the experimental group was no statistical significance with that of the control group (P = 0.17). The average case analysis test score of the experimental group was significantly higher than that of the control group (P < 0.05). The indicators of the experimental group’s feedback were better than those of the control group, such that there were significantly higher learning interest and motivation, a better understanding of diseases and knowledge, improvements in clinical thinking and summary ability, and an active classroom atmosphere in the experimental group (P < 0.05). However, students in the experimental group felt more burdensome.

Conclusion
Compared to the traditional method, the seminar-case learning model showed a higher efficacy. The seminar-case learning model effectively improved students’ outcomes and satisfaction, which helped students narrow the gap between theoretical knowledge and clinical practical application.
Application of Electrical Geophysical Method in Site Selection for Viable Area for Agricultural Practices: A Case Study of Ukpenu-Ibhiese and Iruekpen Edo State-Nigeria
Authors: Isaac Aigbedion , Samuel Salufu 
Published: May 2021

Electrical geophysical method was applied, to select viable area with essential soil nutrients for plant’s growth. Conventional soil test analysis was carried out for the purpose of confirmation. A case study was done at Ukpenu-Ibhiese and Iruekpen in Ekpoma. The result of the electrical resistivity geophysical method showed that southwest and northwest of the area has resistivity values that ranged between 80?m to 170?m while the remaining part of the area has values higher than 170?m, ranged from 580?m to 950?m. Values of organic matter, Nitrogen, Phosphorus, and Potassium, obtained from the soil test in area with 80?m to 170?m indicated good proportion of essential soil nutrients for plant growth while area with resistivity values that ranged from 580?m to 950?m was deficient in essential soil nutrients for plant growth. The results further proved that soil electrical physical properties thus detected and mapped can be used as a proxy of physical, chemical, and biological features relevant for the appropriate site selection and soils management, based on their resistivity behavior, spatial variability, and time dynamics in the area of study.
Modeling and adaptive controlling of cable‐drogue docking system for autonomous underwater vehicles
Authors: Li Zeyu , Liu Weidong , Li Le , Guo Liwei , Zhang Wenbo 
Published: May 2021

SummaryIn this article, a novel cable‐drogue docking system is proposed between an autonomous underwater vehicle (AUV) and one mobile underwater platform, to increase the docking safety and reduce the negative influences of turbulences around the platform shell on the AUV. The mathematical model of the cable‐drogue system and an radial basis function neural network (RBFNN)‐based Q‐learning proportional‐integral‐differential (PID) controller are developed for the system characteristics analysis and the stabilized control. First, the cable‐drogue's mathematical model is established as a link‐joint‐connected system, whose kinematic and dynamic equations are derived subjected to the hydrodynamic forces on system. One numerical solution procedure is also presented to obtain the motion state of the cable‐drogue system. Next, considering the current interferences on the cable‐drogue system, a cross rudder is added on the drogue to enhance the robustness. An RBFNN‐based Q‐learning PID controller is proposed to improve the control performances, in which the control parameters are adaptively optimized by an Q‐learning neural network. Finally, numerical simulations are made to study the steady‐state and dynamic characteristics of the cable‐drogue system in ocean environment, and to investigate the performances of both the traditional PID controller and the proposed RBFNN‐based Q‐learning PID controller in unknown dynamical system. Simulation results show the effectiveness of the kinematic and dynamic equations of the cable‐drogue system and the proposed controller in this article.
Apoptotic Bodies in the Pancreatic Tumor Cell Culture Media Enable Label‐Free Drug Sensitivity Assessment by Impedance Cytometry
Authors: Honrado Carlos , Adair Sara J. , Moore John H. , Salahi Armita , Bauer Todd W. , Swami Nathan S. 
Published: May 2021

AbstractThe ability to rapidly and sensitively predict drug response and toxicity using in vitro models of patient‐derived tumors is essential for assessing chemotherapy efficacy. Currently, drug sensitivity assessment for solid tumors relies on imaging adherent cells or by flow cytometry of cells lifted from drug‐treated cultures after fluorescent staining for apoptotic markers. Subcellular apoptotic bodies (ABs), including microvesicles that are secreted into the culture media under drug treatment can potentially serve as markers for drug sensitivity, without the need to lift cells under culture. However, their stratification to quantify cell disassembly is challenging due to their compositional diversity, with tailored labeling strategies currently needed for the recognition and cytometry of each AB type. It is shown that the high frequency impedance phase versus size distribution of ABs determined by high‐throughput single‐particle impedance cytometry of supernatants in the media of gemcitabine‐treated pancreatic tumor cultures exhibits phenotypic resemblance to lifted apoptotic cells and enables shape‐based stratification within distinct size ranges, which is not possible by flow cytometry. It is envisioned that this tool can be applied in conjunction with the appropriate pancreatic tumor microenvironment model to assess drug sensitivity and toxicity of patient‐derived tumors, without the need to lift cells from cultures.
Template‐Sacrificed Hot Fusion Construction and Nanoseed Modification of 3D Porous Copper Nanoscaffold Host for Stable‐Cycling Lithium Metal Anodes
Authors: Lin Huinan , Zhang Zewen , Wang Yaoda , Zhang Xiao Li , Tie Zuoxiu , Jin Zhong 
Published: May 2021

AbstractLithium (Li) metal anodes have been proposed as a promising candidate for high‐energy‐density electrode materials in secondary batteries. However, the dendrite growth and unstable electrode–electrolyte interfaces during Li plating/stripping are fatal to their practical applications. Herein, the construction of 3D porous Au/Cu nanoscaffold prepared via a convenient template‐sacrificed hot fusion construction method and a nanoseed modification process as an effective Li metal hosting material are proposed. The Au/Cu nanoscaffold can spatially guide uniform deposition of Li metal free from the growth of Li dendrites due to the homogenous Li+ ion flux and negligible nucleation overpotential. Moreover, the Cu skeleton can relieve volume change and stabilize local current density during cycling processes. Benefiting from these advantages, the symmetric cells based on self‐supported Li‐filled Au/Cu (Li‐Au/Cu) nanoscaffold electrodes present highly stable Li plating/stripping for more than 1000 h with a low voltage hysteresis less than 90 mV and a long lifespan over 1300 h at 1.0 mA cm–2 in carbonate‐based electrolytes. Impressively, the Li‐Au/Cu nanoscaffold||LiFePO4 full cells also exhibit exceptional cycling stability and rate performance. This work provides a promising strategy to construct dendrite‐free lithium metal anodes toward high‐performance lithium metal batteries.
Engineering the Deformability of Albumin‐Stabilized Emulsions for Lymph‐Node Vaccine Delivery
Authors: Song Tiantian , Xia Yufei , Du Yiqun , Chen Michael W. , Qing Hong , Ma Guanghui 
Published: May 2021

AbstractA major challenge in vaccine delivery is to achieve robust lymph‐node (LN) accumulation, which can capitalize on concentrated immunocytes and cytokines in LNs to stimulate the onset and persistence of adaptive immune responses. Previous attempts at developing vaccine delivery systems have focused on the sizes, charges, or surface ligands but not on their deformability. In fact, the LN homing of antigen‐presenting cells depends on deformability to pass through the cellular gaps. Herein, the deformability of albumin‐stabilized emulsions is engineered. Owing to self‐adaptive deformability, the droplets (≈330 nm) can attach to and deform between cells and adjust their sizes to pass through the endothelial gaps (20–100 nm), favoring direct LN transfer (intercellular pathway). Additionally, owing to relatively large sizes, some emulsions can be retained at the administration sites for potent antigen uptake and activation of APCs as well as LN‐targeted delivery of vaccines (intracellular pathway). Compared with solid particles, the dual LN transfer strategy evidently enhances antigen accumulation and activation of LN drainage, potently stimulates cellular immune responses, and increases the survival rate of tumor‐bearing mice. Thus, the deformability of albumin‐stabilized droplets may offer an efficient strategy for potent LN targeting and enhanced vaccinations.
Novel deep intronic and frameshift mutations causing a TRIP11‐related disorder
Authors: Qian Yeqing , Hu Gang , Chen Min , Liu Bei , Yan Kai , Zhou Caiyun , Yu Yanqin , Dong Minyue 
Published: May 2021

AbstractMutations of the thyroid hormone receptor interactor 11 gene (TRIP11, OMIM: 604505) at 14q32.12 have been associated with the autosomal recessive achondrogenesis type IA (ACG1A, OMIM: 200600) or osteochondrodysplasia (ODCD, OMIM: 184260). In this clinical report of a Chinese family, the mother had two consecutive pregnancies with similar aberrant phenotypes in the fetuses showing severe limb shortening. Whole exome sequencing (WES) of DNA from the second fetus identified a heterozygous frameshift mutation (NM_004239: c.3852delT) of TRIP11. Although this was consistent with the fetal clinical phenotypes, initial review of the WES results implied another novel mutation. To test this, we used high‐precision clinical exome sequencing (HPCES) and found a mutation in Intron 18 of TRIP11 (c.5457+77T>G). Moreover, the sequencing depth of this mutation was only 3× that of WES compared with 161× that by HPCES. To ascertain the pathogenesis of the mutation (c.5457+77T>G), RT‐PCR conducted using the parents' blood samples showed a 77‐bp intronic sequence in the transcripts, which might have encoded for a shortened protein because of early termination due to code shifting. Our study furthers current understanding of deep intron function and provides a novel diagnostic method of deep intragenic mutations in families having two or more consecutive pregnancies with similar aberrant fetal phenotypes.
Enantioselective Synthesis and Biological Evaluation of Sanglifehrin A and B and Analogs
Authors: Chang Chia‐Fu , Flaxman Hope A. , Woo Christina M. 
Published: May 2021

AbstractSanglifehrin A and B are immunosuppressive macrocyclic natural products endowed with and differentiated by a unique spirocyclic lactam. Herein, we report an enantioselective total synthesis and biological evaluation of sanglifehrin A and B and analogs. Access to the spirocyclic lactam was achieved through convergent assembly of a key pyranone intermediate followed by a stereo‐controlled spirocyclization. The 22‐membered macrocyclic core was synthesized by ring‐closing metathesis in the presence of 2,6‐bis(trifluoromethyl) benzeneboronic acid (BFBB). The spirocyclic lactam and macrocycle fragments were united by a Stille coupling to furnish sanglifehrin A and B. Additional sanglifehrin B analogs with variation at the C40 position were additionally prepared. Biological evaluation revealed that the 2‐CF3 analog of sanglifehrin B exhibited higher anti‐proliferative activity than the natural products sanglifehrin A and B in Jurkat cells. Both natural products induced higher‐order homodimerization of cyclophilin A (CypA), but only sanglifehrin A promoted CypA complexation with inosine‐5′‐monophosphate dehydrogenase 2 (IMPDH2). The synthesis reported herein will enable further evaluation of the spirolactam and its contribution to sanglifehrin‐dependent immunosuppressive activity.