bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the killer immunoglobulin-like receptor genes KIR2DS1 and KIR2DS4 with pediatric autoimmune hepatitis type I in Egypt
Authors: Behairy Ola Galal , El-Shimi Ola Samir , Shalan Naglaa Hamed , Baghdady Shaymaa Mohamed 
Published: September 2021

Abstract
Background
Killer cell immunoglobulin-like receptors (KIR) are considered to be the key receptors that control the development and function of human natural killer cells which play complex mechanisms in autoimmune diseases. We aimed in this study to assess possible associations between killer cell immunoglobulin-like receptors (KIR2DS1 and 2DS4) genes and susceptibility to autoimmune hepatitis type I in Egyptian children.

Results
In the case-control study conducted on eighty children diagnosed as autoimmune hepatitis (AIH) type I and eighty apparently healthy age and sex-matched control, we found that KIR2DS1, -2DS4, KIR2DS4-full length allele, and homozygous KIR2DS4-full/full variant were significantly associated with AIH-I, while the KIR1D allele and homozygous KIR2DS4-del/del variant were significantly observed in controls (P < 0.05 each). Absence of KIR2DS4 gene was significant among ANA positive AIH-I patients, patients on steroid therapy alone, and patients showing complete disease remission (P < 0.05 each). Higher activity and fibrosis indices were found significantly in patients lacking one or both studied genes.

Conclusions
Children carrying KIR2DS1, -2DS4 genes, KIR2DS4-full length allele, and homozygous KIR2DS4-full/full variant could be more susceptible to develop autoimmune hepatitis type I.
El lugar de la lengua de señas como lengua minoritaria en la Accesibilidad Comunicativa Universal
Authors: Melendez Sandra 
Published: September 2021

La lengua de señas es reconocida como derecho lingü.stico de las personas con discapacidad auditiva de todo el mundo. Entre sus principales características como lengua minoritaria, está la urgencia de su preservación, ya que garantiza el derecho a la información y a la comunicación de la comunidad usuaria. En este sentido, estrategias como las guías y pautas de estilo para la comunicación inclusiva cumplen un papel fundamental en su uso, difusión y accesibilidad. Desde un punto de vista hermenéutico, el presente estudio analiza 22 guías publicadas en español para identificar el lugar que ocupa la lengua de señas como lengua minoritaria en la comunicación inclusiva. Se encontró que la lengua de señas se presenta como una de las formas de expresión de las personas con discapacidad auditiva y como herramienta clave en procesos de participación, lo que permite concluir que estas guías contribuyen en su difusión. El análisis permitió la configuración de un modelo de Accesibilidad Comunicativa Universal que, además de garantizar la preservación de formas alternativas de comunicación de las personas con discapacidad como la lengua de señas, promueve la participación plena de esta población y la autoinclusión.
Treatment strategies for scapular spine fractures: a scoping review
Authors: Sußiek Julia , Michel Philipp A. , Raschke Michael J. , Schliemann Benedikt , Katthagen J. Christoph 
Published: September 2021

Fractures of the scapular spine are relatively rare and can occur without (1) or with (2) association to a reverse shoulder arthroplasty (RSA). To date there are only limited data on the topic. The aim of this scoping review was to identify all available literature and report current treatment concepts. A scoping review was conducted by searching PubMed for relevant studies between 2000 and October 2020. All studies were included which gave detailed descriptions of the treatment strategy. A total of 21 studies with 81 patients were included for the analysis. The mean age over all patients was 62 years (range: 24 to 89 years) and 77% of the patients were female. In 19.8% of cases, the fracture occurred after a traumatic fall from standing height. Eighty-six per cent of the patients had an RSA-associated scapular spine fracture (2). These patients were older compared to group (1) (47 ± 19.6 vs. 76 ± 5.6 years, p = 0.0001) and the majority were female (85%). The majority from group (1) underwent operative treatment with plate fixation. Most patients regained full function and range of motion. RSA-associated fractures (2) were mainly treated non-operatively, with moderate clinical outcome. A high rate of nonunions was reported. Scapular spine fractures without RSA are mainly treated operatively with good clinical results. In association with RSA, scapular spine fractures are mainly treated non-operatively and lead to inferior clinical and radiological results. This scenario seems to be problematic and further research is required to sharpen treatment concepts in this group.Cite this article: EFORT Open Rev 2021;6:788-796. DOI: 10.1302/2058-5241.6.200153
Follow-up after emergency laparotomy suggests high one- and five-year mortality with risk stratified by ASA
Authors: Nicoll K , Lucocq J , Khalil T , Khalil M , Watson H , Patil P 
Published: September 2021

Introduction We investigated all-cause mortality following emergency laparotomy at 1 and 5 years. We aimed to establish a basis from which to advise patients and relatives on long-term mortality. Methods Local data from a historical audit of emergency laparotomies from 2010 to 2012 were combined with National Emergency Laparotomy Audit (NELA) data from 2017 to 2020. Covariates collected included deprivation status, preoperative blood work, baseline renal function, age, American Society of Anesthesiologists (ASA) grade, operative time, anaesthetic time and gender. Associations between covariates and survival were determined using multivariate logistic regression and Kaplan–Meier analysis. We used patients undergoing laparoscopic cholecystectomy between 2015 and 2020 as controls. Results ASA grade was the best discriminator of long-term outcome following laparotomy (n=894) but was not a predictor of survival following cholecystectomy (n=1,834), with mortality being significantly greater in the laparotomy group. Following cholecystectomy, 95% confidence intervals for survival at 5 years were 98–99%. Following laparotomy these intervals were: ASA grade 1, 79–96%; ASA grade 2, 69–82%; ASA grade 3, 44–58%; ASA grade 4, 33–48%; and ASA grade 5, 4–51%. The majority of deaths occurred after 30 days. Conclusions Emergency laparotomy is associated with a significantly increased risk of death in the following 5 years. The risk is strongly correlated to ASA grade. Thirty-day mortality estimation is not a good basis on which to advise patients and carers on long-term outcomes. ASA grade can be used to predict long-term outcomes and to guide patient counsel.
Carotid artery elongation (dolichoarteriopathy) and cerebral perfusion: results of a pilot study
Authors: Golovin D. A. , Rostovtseva T. M. , Kudryavtsev Yu. S. , Berdalin A. B. , Lelyuk S. E. , Lelyuk V. G. 
Published: September 2021

Among the causes of brain ischemia, including stroke, the impaired straightness of internal carotid arteries (ICAs) are considered. The article discusses modern views on the causes of ICA geometry disorders, their pathogenetic and hemodynamic significance, and a possible contribution to cerebral lesions.Aim. To study the relationship between the anomalies of ICA configuration and the brain perfusion parameters using cerebral multislice computed tomographic angiography.Material and methods. Seventeen patients after ischemic stroke who had ICA elongation on the contralateral side of infarction: 7 women aged 60-87 years (median [1st quartile; 3rd quartile]: 73 [64; 75]) and 10 men aged 54-80 years (62 [60; 73]). There were also 10 patients of the control group with normal ICA configuration on the contralateral side of infarction: 5 women aged 50-71 years (59 [50; 68]) and 5 men aged 55-81 years (58 [57; 62]). Brain multislice computed tomographic angiography and magnetic resonance imaging were performed. Results. A significant perfusion decrease within normal values in the blood systems of the elongated ICAs was established. The relationship between the degree of ICA elongation and the age of patients, in the absence of such for brain white matter lesions, was recorded. There is the need to continue the study to clarify the nature of the severity and causes of the revealed phenomena.
Acute coronary syndrome in COVID-19 patients
Authors: Chashchin M. G. , Gorshkov A. Yu. , Drapkina O. M. 
Published: September 2021

Acute coronary syndrome (ACS) is caused by an acute mismatch between myocardial oxygen demand and its supply. This mechanism is largely associated with the progression of coronary atherosclerosis in combination with an inflammatory response, hypoxemia, and blood procoagulation. Patients with the coronavirus disease 2019 (COVID-19), aggravated by cardiovascular diseases and comorbidities, are at high risk of ACS.Aim. To analyze the publications, which reflects the development of ACS in patients with COVID-19, its pathogenesis, and clinical course. Material and methods. Literature data were searched using Google Scholar, PubMed, ScienceDirect, and Cyberleninka services. The analysis included data from clinical guidelines on COVID-19, data from clinical studies, reports, and systematic reviews.Results. This literature review summarizes and systematizes the data presented in modern publications, highlights the aspects of the clinical course and pathogenetic mechanisms underlying ACS in patients with COVID-19.Conclusion. The pathogenesis of COVID-19 is inextricably associated with the widespread cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), uncontrolled immune response that causes systemic inflammation, as well as the coagulation system activation. In patients with COVID-19, along with the atherosclerosis, these mechanisms significantly increase the risk of ACS and can worsen its in-hospital course.
COVID-19 as a cause of chronic pulmonary hypertension: pathophysiological rationale and potential of instrumental investigations
Authors: Kobelev E. , Bergen T. A. , Tarkova A. R. , Vasiltseva O. Ya. , Kamenskaya O. V. , Usov V. Yu. , Chernyavsky A. M. 
Published: September 2021

Coronavirus disease 2019 (COVID-19) is a poorly understood and dangerous medical problem. COVID-19-related pulmonary vessels involvement is a complex set of interrelated pathophysiological processes associated with vascular endothelial dysfunction and accompanied by thrombosis of various localization, vasomotor disorders, severe respiratory failure, as well as pulmonary embolism (PE) resulting in chronic thromboembolic pulmonary hypertension (CTEPH). According to computed tomographic pulmonary angiography, the incidence of PE in patients with COVID-19 ranges from 23 to 30%. The aim of this work was to focus the doctors' attention on the risk of pulmonary hypertension in patients after COVID-19.Despite the ability of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) to infect various organs and systems, the main and most serious complications are pulmonary infiltration, acute respiratory distress syndrome, acute respiratory failure and PE, which in some cases becomes the triggering mechanism for CTEPH development. The literature review presents data on main pathological abnormalities developing in target organs during COVID-19 and playing an important role in increasing the CTEPH risk. The paper describes the main methods of instrumental investigations of CTEPH and an algorithm for its use in COVID-19 survivors.The revealed data demonstrated that the absence of obvious signs of pulmonary hypertension/CTEPH, the cardiopulmonary system abnormalities cannot be ruled out. Therefore, it seems appropriate to actively follow up COVID-19 survivors. A thoroughly, purposefully collected anamnesis, pulmonary function tests and stress echocardiography in an ambiguous clinical situation will play a leading role as they identify cardiopulmonary disorders and provide the doctor with basic information for further planning of patient management.
Role of biobanking in managing large-scale epidemiological studies
Authors: Pokrovskaya M. S. , Borisova A. L. , Metelskaya V. A. , Efimova I. A. , Doludin Yu. V. , Kozlova V. A. , Serebryanskaya Z. Z. , Balanova Yu. A. , Meshkov A. N. , Pustelenin A. V. , Imaeva A. E. , Shalnova S. A. , Kontsevaya A. V. , Drapkina O. M. 
Published: September 2021

The success and quality of large-scale epidemiological studies depends entirely on biomaterial quality. Therefore, when arranging the third Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF-3) study, increased attention was paid to specifics of collection, processing and further transportation of biological samples and related clinical and anthropometric data of participants from regional collection centers to Biobank.Aim. To develop a methodology for collection of high-quality biomaterials within the large-scale epidemiological study, involving the sampling, processing, freezing of blood and its derivatives (serum, plasma) in the regions, followed by transportation and storage of obtained biomaterial in the Biobank of National Medical Research Center for Therapy and Preventive Medicine (Moscow).Material and methods. To conduct the ESSE-RF-3 study, a design was developed, according to which the collection of venous blood samples in a total volume of 29,5 ml from each participant is planned in all participating regions in order to obtain and store samples of whole blood, serum and two types of plasma.Results. On the basis of international biobanking standards, ethical norms, experience from ESSE-RF and ESSE-RF-2, and literature data, a protocol for biobanking of blood and its derivatives was developed. The type and number of serum and plasma aliquots obtained, the required standard technical means and consumables, as well as logistic biomaterial requirements were determined. Training programs for regional participants were developed. By the beginning of August 2021, 180 thousand samples of whole blood, serum and plasma from more than 23 thousand participants from 28 Russian regions were collected, processed and stored.Conclusion. The presented work made it possible to assess and confirm the compliance of developed biobanking protocol with quality requirements. However, due to the coronavirus disease 2019 pandemic, by August 2021, the Biobank did not reach the maximum effectiveness predicted for the ESSE-RF-3 project.
Antiarrhythmic therapy for atrial fibrillation: current guidelines of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery (ESC/EACTS)
Authors: Tarzimanova A. I. , Doshchitsin V. L. 
Published: September 2021

The treatment of atrial fibrillation (AF) remains one of the most difficult tasks in modern cardiology. In 2020, the European Society of Cardiology (ESC), together with the European Association for Cardio-Thoracic Surgery (EACTS), published guidelines for the diagnosis and management of AF, which include several new directives.ESC experts have formulated a novel concept for treatment of AF patients. The first component of treatment ‘A' (Anticoagulation/ Avoid stroke) is anticoagulant therapy in patients with increased risk of thromboembolic events. The second line of treatment ‘B' (Better symptom control) is the control of arrhythmia symptoms, selection of a rhythm control strategy or ventricular rate control. The third direction ‘C' includes cardiovascular risk factors and comorbid conditions management.The most challenging tasks in AF treatment are the control of arrhythmia symptoms. As in the previous version of 2016 guidelines, the latest ones identify 2 following strategies in treatment of AF: rhythm control and ventricular rate control.According to the current ESC/EACTS guidelines (2020), antiarrhythmic therapy continues to be one of the important directions in AF management. Early prescription f antiarrhythmic and anticoagulant agents with an increased risk of thromboembolic events, catheter ablation can not only improve the quality of life, but also the prognosis of patients with AF.
Effect of regional living conditions on middle-term cardiovascular outcomes: data from prospective stage of the ESSE-RF study
Authors: Maksimov S. A. , Shalnova S. A. , Kutsenko V. A. , Balanova Yu. A. , Muromtseva G. A. , Kapustina A. V. , Evstifeeva S. E. , Imaeva A. E. , Karamnova N. S. , Drapkina O. M. 
Published: September 2021

Aim. To assess regional living conditions with cardiovascular outcomes based on prospective stage of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study.Material and methods. We used data from a 3- and 5-year prospective stage of the ESSE-RF study (2012-2013). For initial screening, 16210 people aged 25-64 were included. To characterize the regions of residence, 5 regional indices (RIs) were used. The following endpoints were considered: cardiovascular death, myocardial infarction, stroke, composite endpoint (cardiovascular death + myocardial infarction + stroke). To assess the correlations, generalized estimating equations with nested data structure (individuals in the regions) were used. The studied associations were adjusted for a wide range of potential effect modifiers.Results. There are multiple direct associations of RIs with the likelihood of all endpoints. The exception was the reverse association of Industrial RI with cardiovascular death. The most stable associations regarded Mixed RI, Industrial RI and Socio-geographical RI, with a high RI significance in endpoint development, compared with well-known individual cardiovascular risk factors. Separate associations were noted for Economic RI and Demographic RI.Conclusion. The results indicate a significant contribution of a number of regional living conditions to individual risk of fatal and non-fatal cardiovascular outcomes.
Contribution of cardio-ankle vascular index to prediction of cardiovascular events in the adult urban population: data from the ESSE-RF study (Tomsk)
Authors: Zairova A. R. , Rogoza A. N. , Oshchepkova E. V. , Yarovaya E. B. , Kutsenko V. A. , Shalnova S. A. , Trubacheva I. A. , Kaveshnikov V. S. , Serebryakova V. N. , Boytcov S. A. 
Published: September 2021

Aim. To determine the role of cardio-ankle vascular index (CAVI) in predicting cardiovascular events (CVEs) in adult Russian population using model of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study (Tomsk).Material and methods. We analyzed the data of 1342 people aged 25-64 (4,3±11,6) years, in whom arterial stiffness was assessed as part of the ESSE-RF study using the vascular screening system VaSeraVS-1500, followed by phone contacts, on average, 4,7 years later. We studied the prognostic role of CAVI in relation to primary composite (cardiovascular death, nonfatal myocardial infarction (MI) or stroke) and secondary composite (all CVEs) endpoints.Results. We revealed that prior myocardial infarction or stroke (n=52) is associated with an increase in CVE incidence from 2,3 to 11,5% (p=0,0003) and from 5% to 23% (p<0,001) for primary and secondary composite endpoints, respectively. In a group of 1290 people (without prior MI or stroke), CAVI was significantly higher in men than in women: 7,4±1,4 vs 7,1±1,3 (p=0,002), despite more young age: 45,4±11,8 vs 48,0±11,3 years (p<0,001). The risk criterion for CVE was CAVI >7,8 (relative risk (RR): 5,06; 95% confidence interval (CI): 2,32-11,06) (p<0,001) and (RR: 3,95; 95% CI: 2,37-6,58) (p<0,001), which retains its predictive value when adjusted for conventional risk factors (RR: 3,13; 95% CI: 1,26-7,75) (p=0,014) and (RR: 2,16; 95% CI: 1,18-3,98) (p=0,013) — primary and secondary composite endpoints, respectively.Conclusion. CAVI has a significant independent value in predicting CVEs in Tomsk adult urban population aged 25-64 years. To clarify the cardiovascular risk, vascular screening with identifying CAVI should be carried out during preventive and screening examinations for men over 35 and women over 45.
Unhealthy diet in association with abdominal obesity as risk factors for cardiovascular disease: data from the ESSE-RF2 study in the Omsk region
Authors: Viktorova I. A. , Moiseeva M. V. , Stasenko V. L. , Shirlina N. G. , Livzan M. A. 
Published: September 2021

Aim. To compare dietary patterns of the Omsk region male and female representatives with and without abdominal obesity (AO).Material and methods. Wthin the second study of Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF2) using a representative sample of Omsk region population aged 25-64 years (n=1648), dietary habits, including 21 food groups, were assessed by the questionnaire method. Eating habits of Omsk region representatives with (n=936) and without AO (n=712) were compared.Results. Insufficient consumption of vegetables and fruits practically does not differ in those with or without AO. Depending on sex, insufficient fruit consumption is more typical for both men and women without AO. In addition, there is insignificant increase of fruit consumption in AO people, especially women (p=0,09). Both men (p=0,05) and women (p=0,045) are less likely to consume meat daily but more often consume fish weekly compared to those without AO. This mainly applies to women, because women with AO, in contrast to those without AO, are significantly less likely to consume insufficient amount of fish (p=0,0001). Compared to women with, men with AO significantly more often daily and weekly consume seafood (p=0,001). Daily milk consumption is much less common in individuals with AO, but only at the expense of men with AO (p=0,0001). Kefir and yogurt, on the contrary, are more often consumed in patients with AO both daily and weekly. Omsk people with AO are less likely to introduce yogurt into their daily diet, mainly at the expense of women with AO (p=0,02). Excessive consumption of pasta is more typical for persons without AO (p=0,0001), and by means of men (p=0,001). Omsk residents with AO more often exclude the sweets and confectionery from diet. In the daily diet, they are much less common in individuals with AO (p=0,0001), especially in men with AO (p=0,0001). The respondents with AO daily consume pickles 1,4 times more often compared with those without AO, and mainly by means of men (p=0,03).Conclusion. Presence of AO somewhat changed the dietary habits of Omsk residents. AO patients are less likely to consume pasta, sweets and confectionery products, but more likely to eat pickles and to add more salt to cooked food, which requires targeted preventive measures, taking into account the identified sex priorities, depending on AO presence.