bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant functional connectivity and activity in Parkinson’s disease and comorbidity with depression based on radiomic analysis
Authors: Zhang Xulian , Cao Xuan , Xue Chen , Zheng Jingyi , Zhang Shaojun , Huang Qingling , Liu Weiguo 
Published: March 2021

AbstractIntroductionThe current diagnosis of Parkinson's disease (PD) comorbidity with depression (DPD) largely depends on clinical evaluation. However, the modality may tend to lack precision in detecting PD with depression. A radiomic approach that combines functional connectivity and activity with clinical scores has the potential to achieve accurate and differential diagnosis between PD and DPD.MethodsIn this study, we aimed to employ the radiomic approach to extract large‐scale features of functional connectivity and activity for differentiating among DPD, PD with no depression (NDPD), and healthy controls (HC). We extracted 6,557 features of five types from all subjects including clinical characteristics, resting‐state functional connectivity (RSFC), amplitude of low‐frequency fluctuation (ALFF), regional homogeneity (ReHo), and voxel‐mirrored homotopic connectivity (VMHC). Lasso, random forest, and support vector machine (SVM) were implemented for feature selection and dimension reduction based on the training sets, and the prediction performance for different methods in the testing sets was compared.ResultsThe results showed that nineteen features were selected for the group of DPD versus HC, 34 features were selected for the group of NDPD versus HC, and 17 features were retained for the group of DPD versus NDPD. In the testing sets, Lasso prediction achieved the accuracies of 0.95, 0.96, and 0.85 for distinguishing between DPD and HC, NDPD and HC, and DPD and NDPD, respectively. Random forest achieved the accuracies of 0.90, 0.82, and 0.90 for distinguishing between DPD and HC, NDPD and HC, and DPD and NDPD, respectively, while SVM yielded the accuracies of 1, 0.86 and 0.65 for distinguishing between DPD and HC, NDPD and HC, and DPD and NDPD, respectively.ConclusionsBy identifying aberrant functional connectivity and activity as potential biomarkers, the radiomic approach facilitates a deeper understanding and provides new insights into the pathophysiology of DPD to support the clinical diagnosis with high prediction accuracy.
Proteomics reveals the function reverse of MPSSS‐treated prostate cancer‐associated fibroblasts to suppress PC‐3 cell viability via the FoxO pathway
Authors: Zhang Tingting , Chen Xiulan , Sun Lang , Guo Xiaojing , Cai Tanxi , Wang Jifeng , Zeng Yanqiong , Ma Jing , Ding Xiang , Xie Zhensheng , Niu Lili , Zhang Mengmeng , Tao Ning , Yang Fuquan 
Published: March 2021

AbstractProstate cancer‐associated fibroblasts (prostate CAFs) are essential components of the tumor microenvironment and can promote tumor progression through their immunosuppressive functions. MPSSS, a novel polysaccharide purified from Lentinus edodes, has been reported to have anti‐tumor activity. MPSSS could also inhibit the immunosuppressive function of prostate CAFs, which has been demonstrated through that the secretome of MPSSS‐treated prostate CAFs could inhibit the proliferation of T cells. However, how the secretome of MPSSS‐treated prostate CAFs influence prostate cancer progression is still unclear. Interestingly, we found that the low molecular weight (3–100kD) secretome of prostate CAFs (lmwCAFS) could promote the growth of PC‐3 cells, while that of MPSSS‐treated prostate CAFs (MT‐lmwCAFS) could inhibit their growth. We carried out comparative secretomic analysis of lmwCAFS and MT‐lmwCAFS to identify functional molecules that inhibit the growth of PC‐3 cells, and proteomic analysis of lmwCAFS‐treated PC‐3 cells and MT‐lmwCAFS‐treated PC‐3 cells to investigate the underlying molecular mechanism. These analyses suggest that TGF‐β3 from MT‐lmwCAFS may inhibit the growth of PC‐3 cells. The validated experiments revealed that TGF‐β3 from MT‐lmwCAFS activated p21 expression in PC‐3 cells by regulating the FoxO pathway thereby inducing G0/G1 cell cycle arrest of PC‐3 cells. Overall, our data demonstrated that MPSSS reversed the ability of prostate CAFs to suppress the cell viability of PC‐3 cells, which might provide a potential therapeutic strategy to prevent prostate cancer progression.
A Review of the Application of Steel Slag in CO2 Fixation
Authors: Wang Junya , Zhong Mi , Wu Pengfei , Wen Shikun , Huang Liang , Ning Ping 
Published: March 2021

AbstractSteel slag is the main by‐product during the steel manufacturing process, with the characteristics of large output and low utilization rate. Since the high content of calcium oxide in steel slag, it is often used for CO2 capture. In this paper, progress on the development of steel slag for fixing CO2 is reviewed. This review is organized according to the carbonation type of steel slag, including direct carbonation and indirect carbonation. For direct carbonation, it is introduced from two parts: aqueous carbonation and gas‐solid carbonation. For indirect carbonation, it is summarized according to the extracting agent. The carbonation condition and capacity will be carefully discussed. Besides, the techno‐economic assessments of using steel slag for CO2 capture are discussed. This paper will provide an overview of the steel slag using for CO2 sequestration available and valuable suggestions for future study.
Acute myocardial infarction treated with novel Resolute Onyx and Orsiro stents in the randomized BIONYX trial
Authors: Ploumen Eline H. , Buiten Rosaly A. , Zocca Paolo , Doggen Carine J. M. , Jessurun Gillian A. J. , Schotborgh Carl E. , Roguin Ariel , Danse Peter W. , Benit Edouard , Aminian Adel , Anthonio Rutger L. , Somi Samer , Linssen Gerard C.M. , Hartmann Marc , Kok Marlies M. , von Birgelen Clemens 
Published: March 2021

AbstractObjectivesTo compare 2‐year outcome following treatment with drug‐eluting stents (DES) for acute myocardial infarction (MI) versus non‐MI clinical syndromes. In acute MI patients, a stent‐level comparison was performed, comparing Resolute Onyx versus Orsiro stents.BackgroundIn patients presenting with acute MI, higher adverse event rates have been reported. So far, no clinical results >1 year have been published of acute MI patients treated with Resolute Onyx.MethodsThis post‐hoc analysis of the randomized BIONYX trial(NCT02508714) assessed the main outcome target vessel failure (TVF: cardiac death, target vessel MI, or target vessel revascularization) with Kaplan–Meier methods.ResultsOf all 2,488 trial participants, acute MI patients (n = 1,275[51.2%]) were significantly younger and had less comorbidities than non‐MI patients (n = 1,213[48.8%]). TVF rates were lower in acute MI patients (77/1,275[6.1%] vs. 103/1,213[8.6%], HR:0.70, 95%‐CI 0.52–0.94; plog‐rank = 0.02), mainly driven by target vessel revascularization (4.1 vs. 6.1%, plog‐rank = 0.03). Multivariate analysis showed no independent association of clinical syndrome with TVF (adjusted‐HR: 0.81, 95%‐CI 0.60–1.10; p = .17). In MI patients treated with Resolute Onyx (n = 626) versus Orsiro (n = 649), there was no difference in TVF (6.2 vs. 6.1%; plog‐rank = 0.97) and its components. There was only 1(0.2%) definite‐or‐probable stent thrombosis in RO‐ZES and 8(1.2%) in O‐SES (p = .053).ConclusionsTwo years after treatment with thin‐strut DES in this randomized trial, patients treated for acute MI had lower adverse event rates than non‐MI patients. Yet, these findings were mainly attributable to between‐group differences in patient and lesion characteristics. In patients who underwent PCI for acute MI, both Resolute Onyx and Orsiro showed favorable and similar 2‐year outcomes.
Prenatal diagnosis of a de novo trisomy 20p detected by noninvasive prenatal testing
Authors: Yan Xu , Peng Haiying , Zhang Changjun 
Published: March 2021

AbstractPrenatal diagnosis of trisomy 20p seems to be difficult, considering the capacity of ultrasound to detect mild dysmorphic. NIPT has good performance in detecting fetal trisomy 20p combined with low coverage WGS and karyotype analysis.
Heat Transfer at a Particle‐Tube Wall Contact Point: Impact of Catalyst Configuration on Hot Spots
Authors: Zare Mahdi , Hashemabadi Seyed Hassan , Sheikhi Mohammad 
Published: March 2021

AbstractHot spots tend to cause serious problems owing to probable damages to the reactor wall in intense endothermic reactions leading to safety concerns and enormous repairing costs. The heat transfer of a single cylindrical particle is studied empirically and numerically to evaluate hot spot creation close to the bed wall. Computational fluid dynamcis (CFD) methodology is used to solve the momentum, continuity, and energy equations simultaneously. The newly developed experimental method is applied to validate simulation data using the Chilton‐Colburn analogy. The particle rotation over the X, Y, and Z axes is studied and analysis of variance (ANOVA) is employed to statistically investigate the particle rotation effects on the dimensionless maximum temperature of the reactor wall.
Bioinspired Activation ofN2on Asymmetrical Coordinated Fe Grafted1T MoS2at Room Temperature†
Authors: Guo Jiaojiao , Wang Maoyu , Xu Liang , Li Xiaomin , Iqbal Asma , Sterbinsky George E. , Yang Hao , Xie Miao , Zai Jiantao , Feng Zhenxing , Cheng Tao , Qian Xuefeng 
Published: March 2021

Main observation and conclusionInspired by the nitrogen fixation process on MoFe nitrogenase, asymmetrical coordinated Fe grafted onto 1T MoS2were successfully synthesized. The unique electron‐rich structure with asymmetrical coordination made the 1T Fe0.1Mo0.9S2layered material actively react with water and dinitrogen at room temperature and atmosphere pressure. Subsequently, ammonia can be produced with a yield of ~800 μmol (NH4+) g−1(12.5% yield in mole). The activation, fixation and reduction of dinitrogen were confirmed by isotopically labeled experiments. The location and the specific coordination environment of grafted Fe in Fe‐Mo‐S were further determined by X‐ray absorption spectroscopy analysis. Our work demonstrates that the nitrogen fixation and reduction for ammonia at room temperature without any chemical and electrochemical assistance is distinctly different from traditional bionic‐inspired nitrogen fixation process. The mechanism of the activation and reduction of N2was further investigated by density functional theory calculation and Raman spectra. Compared with 1T MoS2, the enriched electron nature and asymmetrical coordination of Fe in Fe‐Mo‐S materials play a critical role in the bioinspired activation of N2at ambient condition.
Prediction models for breast cancer prognosis among Asian women
Authors: Fan Run , Chen Yufan , Nechuta Sarah , Cai Hui , Gu Kai , Shi Liang , Bao Pingping , Shyr Yu , Shu Xiao‐Ou , Ye Fei 
Published: March 2021

BackgroundRobust and reliable prognosis prediction models have not been developed and validated for Asian patients with breast cancer, a rapidly growing yet understudied population in the United States.MethodsWe used longitudinal data from the Shanghai Breast Cancer Survival Study, a population‐based prospective cohort study (n = 5042), to develop prediction models for 5‐ and 10‐year disease‐free survival (DFS) and overall survival (OS). The initial models considered age at diagnosis, tumor grade, tumor size, number of positive nodes, TNM stage, chemotherapy, tamoxifen therapy, and estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status. We then evaluated whether the addition of modifiable lifestyle factors (physical activity, soy isoflavones intake, and postdiagnostic weight change) improved the models. All final models have been validated internally and externally in the National Cancer Database when applicable.ResultsOur final models included age at diagnosis, tumor grade, tumor size, number of positive nodes, TNM stage, chemotherapy, tamoxifen therapy, ER status, PR status, 6‐month postdiagnostic weight change, interaction between ER status and tamoxifen therapy, and interaction between age and TNM stage. The internal validation yielded C‐statistics of 0.76, 0.74, 0.78, and 0.75 for 5‐year DFS, 10‐year DFS, 5‐year OS, and 10‐year OS, respectively. The external validation yielded C‐statistics of 5‐ and 10‐year OS both at 0.78 for Chinese ethnicity, 0.79 for East Asian ethnicity, and 0.75 and 0.76 for all ethnic groups combined.ConclusionWe developed prediction models for breast cancer prognosis from a large prospective study. Our prognostic models performed very well in women from the United States—particularly in Asian American women—and demonstrated high prediction accuracy and generalizability.
Evaluation of Pharmacokinetics, Safety, and Drug‐Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults
Authors: Shimizu Hidetoshi , Nishimura Yukiko , Shiide Yoichi , Matsuda Hideaki , Akimoto Makoto , Matsuda Munetomo , Nakamaru Yoshinobu , Kato Yuichiro , Kondo Kazuoki 
Published: March 2021

AbstractIntravenous (IV) edaravone is approved as an amyotrophic lateral sclerosis (ALS) treatment. Because IV administration places a burden on patients, development of orally administered ALS treatments is needed. Therefore, 2 phase 1 studies of oral formulations of edaravone in healthy subjects examined the pharmacokinetics (PK), safety, racial differences, and drug‐drug interactions (DDIs) and investigated the dose of the oral formulation considered to be bioequivalent to the approved dose of the IV formulation. Study 1 was a placebo‐controlled, randomized, single‐blind study of single‐ascending‐dose oral edaravone with the dose range of 30 to 300 mg (n = 56). Study 2 was conducted in 2 cohorts (n = 84); the first assessed DDIs with multiple‐dose edaravone 120 mg/day given over 5 or 8 days (coadministered with single‐dose rosuvastatin, sildenafil, or furosemide), and the second evaluated PK and racial (Japanese/White) differences in PK parameters with doses of 100‐mg edaravone. The oral formulation of edaravone was well absorbed, and plasma concentrations of unchanged edaravone increased more than dose proportionally within the dose range of 30 to 300 mg. No effect of race on oral edaravone PK and no notable DDI effects possibly caused by orally administered edaravone were observed. The oral edaravone formulations were safe and tolerable under the assessed conditions. Mathematical modeling determined that equivalent exposures in plasma with the approved dose of the IV edaravone formulation, as reported previously, could be achieved when the oral edaravone formulation was administered at a dose of ≈100 mg, with an absolute bioavailability of ≈60%.
Spectroscopic Investigation of Chalcogen Bonding: Halide–Carbon Disulfide Complexes
Authors: Haakansson Christian T. , Corkish Timothy R. , Watson Peter D. , Robinson Hayden T. , Tsui Terrence , McKinley Allan J. , Wild Duncan A. 
Published: March 2021

AbstractA combined experimental and theoretical approach has been used to study intermolecular chalcogen bonding. Specifically, the chalcogen bonding occurring between halide anions and CS2 molecules has been investigated using both anion photoelectron spectroscopy and high‐level CCSD(T) calculations. The relative strength of the chalcogen bond has been determined computationally using the complex dissociation energies as well as experimentally using the electron stabilisation energies. The anion complexes featured dissociation energies on the order of 47 kJ/mol to 37 kJ/mol, decreasing with increasing halide size. Additionally, the corresponding neutral complexes have been examined computationally, and show three loosely‐bound structural motifs and a molecular radical.
Swarm intelligence‐based optimal device deployment in heterogeneous Internet of Things networks for wind farm application
Authors: M Vergin Raja Sarobin , Jani Anbarasi L. , Prassanna J. , Manikandan R. , Al‐Turjman Fadi 
Published: March 2021

SummaryInternet of Things (IoT) is becoming a suitable surveillance system in modern power grid, right from power generation to distribution. In the case of wind power generation application, the entire wind farm is considered completely monitored using edge devices known as IoT devices. Device deployment is a major obstacle that can be addressed for this application as unfair device deployment can lead to connectivity issue. This study has two main objectives. The first objective is to determine the optimal number of IoT devices that need to be place in the potential key elements of the wind turbines/targets for coverage assurance. The second objective is to determine the optimal number of relay devices. Spacing wind turbines several hundred meters apart brings the connectivity as a second critical issue, which can be handling by placing optimal number of relay devices. Hence, the focus of this study is to address connected target coverage problem in optimal device placement of heterogeneous IoT network for wind farm monitoring. This paper discusses in detail the swarm intelligence technique known as particle swarm optimization (PSO) to solve the connectivity issue and to minimize the cost of devices deployment. Additionally, a hybrid swarm intelligence model called hybrid PSO‐ACO (HPACO) algorithm is proposed. The main goal of this hybrid model is to reduce the number of relay devices, minimize deployment cost, and to improve network connectivity. The performance of both PSO and HPACO algorithms are validating by comparing the extensive simulation results with ant colony optimizations (ACO) algorithm and other approximation algorithm.
A systematic review of human paternal oxytocin: Insights into the methodology and what we know so far
Authors: Grumi Serena , Saracino Annalisa , Volling Brenda L. , Provenzi Livio 
Published: March 2021

AbstractWith the consolidation of fathers’ engagement in caregiving, understanding the neuroendocrine and hormonal mechanisms underlying fatherhood becomes a relevant topic. Oxytocin (OT) has been linked with maternal bonding and caregiving, but less is known about the role of OT in human fatherhood and paternal caregiving. A systematic review of methods and findings of previous OT research in human fathers was carried. The literature search on PubMed and Scopus yielded 133 records. Twenty‐four studies were included and analyzed. Significant variability emerged in OT methodology, including laboratory tasks, assessment methods, and outcome measures. Fathers’ OT levels appear to increase after childbirth. OT was significantly correlated with less hostility and with the quality of paternal physical stimulation in play interactions, but not with paternal sensitivity. Fathers’ and children's OT levels were significantly correlated in a limited subset of studies, intriguingly suggesting that cross‐generational OT regulation may occur during the early years of life. This study highlights relevant issues and limitations of peripheral OT assessment in human subjects, especially in fathers. Although the study of paternal neuroendocrinology appears promising, coping with these issues requires dedicated efforts and methodological suggestions are provided to guide future advances in this field.
Flexibility in Red Sea Tridacna maxima‐Symbiodiniaceae associations supports environmental niche adaptation
Authors: Rossbach Susann , Hume Benjamin C. C. , Cárdenas Anny , Perna Gabriela , Voolstra Christian R. , Duarte Carlos M. 
Published: March 2021

AbstractGiant clams (Tridacninae) are important members of Indo‐Pacific coral reefs and among the few bivalve groups that live in symbiosis with unicellular algae (Symbiodiniaceae). Despite the importance of these endosymbiotic dinoflagellates for clam ecology, the diversity and specificity of these associations remain relatively poorly studied, especially in the Red Sea. Here, we used the internal transcribed spacer 2 (ITS2) rDNA gene region to investigate Symbiodiniaceae communities associated with Red Sea Tridacna maxima clams. We sampled five sites spanning 1,300 km (10° of latitude, from the Gulf of Aqaba, 29°N, to the Farasan Banks, 18°N) along the Red Sea's North‐South environmental gradient. We detected a diverse and structured assembly of host‐associated algae with communities demonstrating region and site‐specificity. Specimens from the Gulf of Aqaba harbored three genera of Symbiodiniaceae, Cladocopium, Durusdinium, and Symbiodinium, while at all other sites clams associated exclusively with algae from the Symbiodinium genus. Of these exclusively Symbiodinium‐associating sites, the more northern (27° and 22°) and more southern sites (20° and 18°) formed two separate groupings despite site‐specific algal genotypes being resolved at each site. These groupings were congruent with the genetic break seen across multiple marine taxa in the Red Sea at approximately 19°, and along with our documented site‐specificity of algal communities, contrasted the panmictic distribution of the T. maxima host. As such, our findings indicate flexibility in T. maxima‐Symbiodiniaceae associations that may explain its relatively high environmental plasticity and offers a mechanism for environmental niche adaptation.
Vital rates of two small populations of brown bears in Canada and range‐wide relationship between population size and trend
Authors: McLellan Michelle L. , McLellan Bruce N. , Sollmann Rahel , Wittmer Heiko U. 
Published: March 2021

AbstractIdentifying mechanisms of population change is fundamental for conserving small and declining populations and determining effective management strategies. Few studies, however, have measured the demographic components of population change for small populations of mammals (<50 individuals). We estimated vital rates and trends in two adjacent but genetically distinct, threatened brown bear (Ursus arctos) populations in British Columbia, Canada, following the cessation of hunting. One population had approximately 45 resident bears but had some genetic and geographic connectivity to neighboring populations, while the other population had <25 individuals and was isolated. We estimated population‐specific vital rates by monitoring survival and reproduction of telemetered female bears and their dependent offspring from 2005 to 2018. In the larger, connected population, independent female survival was 1.00 (95% CI: 0.96–1.00) and the survival of cubs in their first year was 0.85 (95% CI: 0.62–0.95). In the smaller, isolated population, independent female survival was 0.81 (95% CI: 0.64–0.93) and first‐year cub survival was 0.33 (95% CI: 0.11–0.67). Reproductive rates did not differ between populations. The large differences in age‐specific survival estimates resulted in a projected population increase in the larger population (λ = 1.09; 95% CI: 1.04–1.13) and population decrease in the smaller population (λ = 0.84; 95% CI: 0.72–0.95). Low female survival in the smaller population was the result of both continued human‐caused mortality and an unusually high rate of natural mortality. Low cub survival may have been due to inbreeding and the loss of genetic diversity common in small populations, or to limited resources. In a systematic literature review, we compared our population trend estimates with those reported for other small populations (<300 individuals) of brown bears. Results suggest that once brown bear populations become small and isolated, populations rarely increase and, even with intensive management, recovery remains challenging.