bluuebunny/crossref_metadata_2025_split huggingface dataset:
Middle trapezius transfer for treatment of irreparable supraspinatus tendon tears- anatomical feasibility study
Authors: Moroder Philipp , Akgün Doruk , Lacheta Lucca , Thiele Kathi , Minkus Marvin , Maziak Nina , Khakzad Thilo , Festbaum Christian , Rüttershoff Katja , Ellermann Sophia , Weiss Torsten , Jöns Thomas , Danzinger Victor 
Published: January 2021

AbstractPurposeThe purpose of this study was to investigate the anatomical feasibility of a middle trapezius transfer below the acromion for treatment of irreparable supraspinatus tendon tears.MethodsThis study involved 20 human cadaveric shoulders in 10 full-body specimens. One shoulder in each specimen was dissected and assessed for muscle and tendon extent, force vectors, and distance to the neurovascular structures. The opposite shoulder was used to evaluate the surgical feasibility of the middle trapezius transfer via limited skin incisions along with an assessment of range of motion and risk of neurovascular injury following transfer.ResultsThe harvested acromial insertion of the middle trapezius tendon showed an average muscle length of 11.7 ± 3.0 cm, tendon length of 2.7 ± 0.9 cm, footprint length of 4.3 ± 0.7 cm and footprint width of 1.4 ± 0.5 cm. The average angle between the non-transferred middle trapezius transfer and the supraspinatus was 33 ± 10° in the transversal plane and 34 ± 14° in the coronal plane. The mean distance from the acromion to the neurovascular bundle was 6.3 ± 1.3 cm (minimum: 4.0 cm). During surgical simulation there was sufficient excursion of the MTT without limitation of range of motion in a retracted scapular position but not in a protracted position. No injuries to the neurovascular structures were noted.ConclusionTransfer of the acromial portion of the middle trapezius for replacement of an irreparable supraspinatus seems to be feasible in terms of size, vector, excursion, mobility and safety. However, some concern regarding sufficiency of transfer excursion remains as scapula protraction can increase the pathway length of the transfer.Level of evidenceBasic Science Study/Anatomical Study
Reducing suicidal ideation among Turkish migrants in the Netherlands and in the UK: the feasibility of a randomised controlled trial of a guided online intervention
Authors: Eylem Ozlem , van Straten Annemieke , de Wit Leonore , Rathod Shanaya , Bhui Kamaldeep , Kerkhof Ad J. F. M. 
Published: January 2021

Abstract
Background
The evidence for the effectiveness of e-mental health interventions among ethnic minorities is still preliminary. This mixed methods study investigates the feasibility of a culturally adapted, guided online intervention with the intention to understand how it works and for whom to inform refinement. It also examines its likely effectiveness in reducing suicidal ideation when compared with the treatment as usual.

Methods
Turkish migrants with mild to moderate suicidal thoughts were recruited from the general population using social media and newspaper advertisements. The intervention group obtained direct access to a 6-week guided online intervention while participants in the waiting list condition had to wait for 6 weeks. The intervention is based on an existing online intervention and was culturally adapted. Participants in both conditions completed baseline, post-test, and follow-up questionnaires on suicidal ideation (primary outcome), depression, worrying, hopelessness, suicide attempt and self-harm, acculturation, quality of life, and usability. In addition, participants were interviewed to examine the feasibility and mechanisms of action in more depth. The responses were analysed by inductive thematic analysis.

Results
Eighty-five people signed up via the study website, and we included 18 (10 intervention, 8 waitlist control). While the therapeutic benefits were emphasised (e.g. feeling connected with the intervention), the feasibility was judged to be low. The main reasons given were not having severe suicidal thoughts and not being represented by the culturally adapted intervention. No suicide attempts were recorded during the study. The suicidal ideation, depression, and hopelessness scores were improved in both groups.

Conclusion
Although intended to be a definitive trial, the current study became a feasibility study with process evaluation to understand the components and how they operate. The online intervention was not superior to the control condition. Future studies need to attend the implementation issues raised including measures of stigma, acculturation, and careful cultural adaptations alongside more attention to coaching and relational support. They should also consider how to improve engagement alongside selection of those who are motivated to use online interventions and offer alternatives for those who are not.

Trial registration
Netherlands Trial Register, NTR5028. Registered on 1 March 2015
Experiences of an HCV Patient engagement group: a seven-year journey
Authors:   UNC Chapel Hill HCV Patient Engagement Group, Kixmiller Scott , Sloan Anquenette P. , Wadsworth Summer , Brown Finton , Chaney Lourdes , Houston Larry , Thomas Kim 
Published: January 2021

AbstractHistorically, few publications exist where patient engagement in clinical studies is a driving force in study design and implementation. The Patient Centered Outcomes Research Institute (PCORI), established in 2010, employed a new model of integrating stakeholder perspectives into healthcare research. This manuscript aims to share the experience of a Patient Engagement Group (PEG) that has engaged in hepatitis C (HCV) clinical research alongside investigators conducting two studies funded by PCORI and to inspire others to get more involved in research that can impact our healthcare and health policies.There are many gaps in treating infectious diseases. Traditionally, treatment and research have been strictly clinical/medical approaches with little focus on the biopsychosocial aspects of individual patients. Our PEG reflected on its own personal experiences regarding how research design can affect study implementation by including patients who are normally excluded. We considered barriers to treatment, out of pocket costs, access to insurance, and patient race/ethnicity. Common themes were discovered, and four major topics were discussed. In addition, measures used in the two studies to collect patient data were considered, tested, and implemented by the group.We describe in detail how we were formed and how we have worked together with researchers on two PCORI funded projects over the past 7 years. We formulated and implemented guidelines and responsibilities for operating as a PEG as well as appointing a chair, co-chair, and primary author of this manuscript.Written from the perspective of a PEG whose members experienced HCV treatment and cure, we provide lessons learned, and implications for further research to include patients. PEGs like ours who are included as active partners in research can provide useful input to many areas including how patients are treated during clinical trials, how they interact with research teams, and how the clinical benefits of drugs or devices are defined and evaluated. PCORI believes engagement impacts research to be more patient-centered, useful, and trustworthy, and will ultimately lead to greater use and interest of research results by the patient and the broader healthcare community.
Weathering the storm: contesting disaster governance after Hurricane Matthew in Haiti
Authors: Melis Samantha , Jean Mikel 
Published: January 2021

AbstractAs a disaster unfolds, survivors’ experiences, actions and motives often become overshadowed by the humanitarian response. This is especially the case in contexts where the national state and international organizations are seen to perpetuate (colonial) power structures. This article is based on 4 months of fieldwork in Haiti, where the authors conducted interviews and focus group discussions with people affected by Hurricane Matthew and with a variety of state officials and humanitarian response actors in Port-au-Prince, Jérémie, Les Cayes and Dame Marie. This study aimed to understand the role and power of societal actors in a context where there is a strong disarticulation between the state and society. The findings show that state–society tensions have been intensified in the response, leading to the politicization of aid and limiting the inclusion of affected communities in disaster governance. In this context, society-based actors negotiate the conditions of aid through resistance and solidarity, with strategies ranging from public protests to everyday resistance and from social networks to alternative aid structures. The article argues that disarticulation between society and the state needs to be addressed to make a more locally led response possible.
SARS-CoV-2 infection in an infant with non-respiratory manifestations: a case report
Authors: Adel Muhammad , Magdy Ahmed 
Published: January 2021

Abstract
Background
Coronavirus disease (COVID-19) presents in children usually with less severe manifestations than in adults. Although fever and cough were reported as the most common symptoms, children can have non-specific symptoms. We describe an infant with aplastic anemia as the main manifestation.

Case presentation
We describe a case of SARS-CoV-2 infection in an infant without any respiratory symptoms or signs while manifesting principally with pallor and purpura. Pancytopenia with reticulocytopenia was the predominant feature in the initial laboratory investigations, pointing to aplastic anemia. Chest computed tomography surprisingly showed typical findings suggestive of SARS-CoV-2 infection. Infection was later confirmed by positive real-time reverse transcription polymerase chain reaction assay (RT-PCR) for SARS-CoV-2.

Conclusions
Infants with COVID-19 can have non-specific manifestations and a high index of suspicion should be kept in mind especially in regions with a high incidence of the disease. Chest computed tomography (CT) and testing for SARS-CoV-2 infection by RT-PCR may be considered even in the absence of respiratory manifestations.
Interest and Willingness to Pay for Integrative Therapies of Patients With Cancer and Caregivers
Authors: Larbi Olivia M. , Jiang Cherry , McLane Bethanny , Wang Gi-Ming , Daunov Katherine , Hobson Sean M. , Daly Barbara , Mazanec Susan R. , Feyes Denise , Rodgers-Melnick Samuel , Li Ming , Momotaz Hasina , Lee Richard T. 
Published: January 2021

PURPOSE: Complementary and integrative medicine (CIM) services are more prevalent in cancer centers but continue to be underutilized by patients. This study examines perspectives from patients and caregivers about these services being offered at a comprehensive cancer center. METHODS: Patients and caregivers were surveyed about their familiarity, interest, and experience with five CIM therapies: acupuncture, massage, meditation, music therapy, and yoga. Respondents were asked about their interest in and/or paying for these services at baseline, when recommended by their medical team, and when offered in a clinical trial. Respondents were also asked about perceived barriers to accessing these services. Chi-squared tests were performed to explore associations between past experience, interest levels, and willingness to pay. RESULTS: A total of 576 surveys were obtained (464 patients and 112 caregivers). Most respondents identified as White or Caucasian (65.6%), female (57.2%), had been a patient for < 3 years (74.2%), had some college education (73.8%), and made > $40,000 in US dollars as their annual household income (69.1%). Respondents were most familiar with therapeutic massage (34.2%) and least familiar with acupuncture (20.0%). The average interest in these services increased from 53.3% to 64.1% when recommended by a medical professional. Respondents were most willing to pay $1-60 for therapeutic massage (62.3%) and least willing to pay for meditation (43.7%). The main barriers to accessing CIM services were cost (56.0%) and lack of knowledge (52.1%). CONCLUSION: Overall, a significant proportion of patients and caregivers were unfamiliar with these five integrative therapies. Increasing education, decreasing cost, and a recommendation by medical professionals would improve CIM usage.
Impact of Conditioning Intensity and Genomics on Relapse After Allogeneic Transplantation for Patients With Myelodysplastic Syndrome
Authors: Dillon Laura W. , Gui Gege , Logan Brent R. , Fei Mingwei , Ghannam Jack , Li Yuesheng , Licon Abel , Alyea Edwin P. , Bashey Asad , Devine Steven M. , Fernandez Hugo F. , Giralt Sergio , Hamadani Mehdi , Howard Alan , Maziarz Richard T. , Porter David L. , Warlick Erica D. , Pasquini Marcelo C. , Scott Bart L. , Horwitz Mitchell E. , Deeg H. Joachim , Hourigan Christopher S. 
Published: January 2021

PURPOSE Patients with myelodysplastic syndrome (MDS) are at risk of relapse after allogeneic hematopoietic cell transplantation. The utility of ultra-deep genomic testing to predict and the impact of conditioning intensity to prevent MDS relapse are unknown. METHODS Targeted error-corrected DNA sequencing was performed on preconditioning blood samples from patients with MDS (n = 48) from the Blood and Marrow Transplant Clinical Trials Network 0901 phase III randomized clinical trial, which compared outcomes by allogeneic hematopoietic cell transplantation conditioning intensity in adult patients with < 5% marrow myeloblasts and no leukemic myeloblasts in blood on morphological analysis at the time of pretransplant assessment. Clinical end points (53-month median follow-up) included transplant-related mortality (TRM), relapse, relapse-free survival (RFS), and overall survival (OS). Of the 48 patients examined, 14 experienced TRM, 23 are relapse-free, and 11 relapsed, of which 7 died. RESULTS Using a previously described set of 10 gene regions, 42% of patients (n = 20) had mutations detectable before random assignment to reduced intensity conditioning (RIC) or myeloablative conditioning (MAC). Testing positive was associated with increased rates of relapse (3-year relapse, 40% v 11%; P = .022) and decreased OS (3-year OS, 55% v 79%, P = .045). In those testing positive, relapse rates were higher (3-year relapse, 75% v 17%; P = .003) and RFS was lower (3-year RFS, 13% v 49%; P = .003) in RIC versus MAC arms. Testing additional genes, including those associated with MDS, did not improve prognostication. CONCLUSION This study provides evidence that targeted DNA sequencing in patients with MDS before transplant can identify those with highest post-transplant relapse rates. In those testing positive, random assignment to MAC lowered but did not eliminate relapse risk.
A Panel Study of Fertility Preferences and Contraceptive Dynamics in the Presence of Competing Pregnancy Risks in Uganda
Authors: Sarnak Dana O. , Tsui Amy , Makumbi Fredrick , Kibira Simon Peter Sebina , Ahmed Saifuddin 
Published: January 2021

Abstract
Although many studies have examined the influence of women's fertility preferences on subsequent fertility behavior and the role of contraceptive use intentions on unmet need, very few have explored their concurrent effects on contraceptive use dynamics. This study examines the independent concurrent effects of women's fertility preferences and contraceptive intentions on subsequent adoption and discontinuation, treating pregnancy as a competing risk factor that may alter contraceptive need. The data are derived from a 2018 follow-up survey of a 2014 national sample of 3,800 Ugandan female respondents of childbearing age. The survey included a contraceptive calendar that recorded pregnancy, birth, and contraceptive event episodes, including reasons for discontinuation. We use competing risk regression to estimate the effect of fertility preferences and contraceptive intentions on the cumulative incidence function of contraceptive behaviors, accounting for intervening pregnancy, female background covariates, loss to follow-up, and complex survey design. We find that women's contraceptive intentions significantly increase the rate of contraceptive adoption. After having adopted, women's contraceptive intentions have been realized and do not prolong use. The risk of discontinuation among women who adopted after baseline was significantly higher than for those using at baseline, irrespective of their initial intentions. The effectiveness of the type of contraceptive method chosen significantly lowered discontinuation risk. Fertility preferences were not significantly associated with either time to adoption or discontinuation. The pace of the fertility transition in this sub-Saharan African setting is likely being shaped by reproductive regulation through the intentional use of contraception that enables spacing births.
Leaders and Laggards in Life Expectancy Among European Scholars From the Sixteenth to the Early Twentieth Century
Authors: Stelter Robert , de la Croix David , Myrskylä Mikko 
Published: January 2021

Abstract
When did mortality first start to decline, and among whom? We build a large, new data set with more than 30,000 scholars covering the sixteenth to the early twentieth century to analyze the timing of the mortality decline and the heterogeneity in life expectancy gains among scholars in the Holy Roman Empire. The large sample size, well-defined entry into the risk group, and heterogeneity in social status are among the key advantages of the new database. After recovering from a severe mortality crisis in the seventeenth century, life expectancy among scholars started to increase as early as in the eighteenth century, well before the Industrial Revolution. Our finding that members of scientific academies—an elite group among scholars—were the first to experience mortality improvements suggests that 300 years ago, individuals with higher social status already enjoyed lower mortality. We also show, however, that the onset of mortality improvements among scholars in medicine was delayed, possibly because these scholars were exposed to pathogens and did not have germ theory knowledge that might have protected them. The disadvantage among medical professionals decreased toward the end of the nineteenth century. Our results provide a new perspective on the historical timing of mortality improvements, and the database accompanying our study facilitates replication and extensions.
To Survive on This Shore
Authors: Dugan Jess T. , Fabbre Vanessa 
Published: January 2021

Abstract
For over five years, photographer Jess T. Dugan and social worker Vanessa Fabbre traveled throughout the United States creating To Survive on This Shore: Photographs and Interviews with Transgender and Gender Nonconforming Older Adults. Seeking subjects whose lived experiences exist at the complex intersections of gender identity, age, race, ethnicity, sexuality, socioeconomic class, and geographic location, they documented the life stories of this important but largely underrepresented group of older adults. The resulting photographs and interviews provide a nuanced view into the struggles and joys of growing older as a transgender person and offer a poignant reflection on what it means to live authentically despite seemingly insurmountable odds.
Reliability of Hand-Held Dynamometer for assessing Isometric Lumbar Muscles Strength in Asymptomatic Healthy Population
Authors: Tanveer Fahad , Arslan Syed Asadullah , Darain Haider , Ahmad Ashfaq 
Published: January 2021

Objective: To determine intra-rater and inter-rater reliability of hand-held dynamometer for assessing isometric lumbar muscle strength in asymptomatic healthy population.
Methods: It was a cross-sectional study conducted at the department of physiotherapy, University of Lahore Teaching Hospital, Lahore, Pakistan, from July 2020 to August 2020 through non probability-purposive sampling technique. Thirty healthy subjects were tested at thirty-degree lumbar flexion and zero-degree lumbar extension positions. Two raters assessed isometric strength of lumbar flexor and extensor muscles, by a hand-held dynamometer. Strength was measured and recorded by each of the two raters and re-assessed after a week. Correlation and pairwise comparison were done between readings. ICC values were calculated for the assessment of isometric lumbar muscle strength using handheld dynamometer.
Results: A total of 30 healthy subjects had participated with mean age of 22.84±1.21 years, height 174.33±6.83 cm, weight 68.58±5.08 kg and BMI 22.52±0.35. Findings showed an excellent intra-rater (ICC 2, k = 0.95 to 0.97) and inter-rater (ICC 2, k = 0.94 to 0.95) reliability.
Conclusions: Hand held dynamometer demonstrated an excellent intra- and inter-rater reliability for assessment of isometric lumbar muscles strength of healthy subject at clinical setting as it is simple to use, portable and cost-effective for the precise measurement of lumbar muscles strength.
doi: https://doi.org/10.12669/pjms.37.2.3621
How to cite this:Tanveer F, Arslan SA, Darain H, Ahmad A. Reliability of Hand-Held Dynamometer for assessing Isometric Lumbar Muscles Strength in Asymptomatic Healthy Population. Pak J Med Sci. 2021;37(2):461-465. doi: https://doi.org/10.12669/pjms.37.2.3621
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pulse combination and compression in hollow-core fiber for few-cycle intense mid-infrared laser generation
Authors: Qian Junyu , Wang Pengfei , Peng Yujie , Li Yanyan , Shao Beijie , Su Hongpeng , Lv Xinlin , Wang Ding , Leng Yuxin , Li Ruxin 
Published: January 2021

The generation of high-peak-power, few-cycle mid-infrared (MIR) pulses using coherent beam combination and nonlinear pulse compression techniques simultaneously is demonstrated. The two pulses, with identical pulse energy of 2.8 mJ and pulse duration of 160 fs, are coherently combined at the input end of a krypton-filled hollow-core fiber (HCF), and then the bandwidth of the combined pulse is broadened to near an optical octave due to strong phase modulations, and the temporal width is compressed into a few-cycle regime. Finally, a 2.7 mJ, 22.9 fs, 20 Hz laser at 4 μm can be obtained, and the pulse peak power is greatly enhanced compared with that of conventional single-channel optical parametric chirped pulse-amplification systems. Furthermore, the peak power generated from this system has the prospect of further scaling up through use of more channels of coherent combination, which can pave a way to generate higher peak power ultra-intense MIR pulses for strong-field physics.