bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging
Authors: Marwick Thomas H , Gimelli Alessia , Plein Sven , Bax Jeroen J , Charron Phillippe , Delgado Victoria , Donal Erwan , Lancellotti Patrizio , Levelt Eylem , Maurovich-Horvat Pal , Neubauer Stefan , Pontone Gianluca , Saraste Antti , Cosyns Bernard , Edvardsen Thor , Popescu Bogdan A , Galderisi Maurizio , Derumeaux Genevieve ,   Reviewers: This document was reviewed by members of the 2020–2022 EACVI Scientific Documents Committee, Bäck Magnus , Bertrand Philippe B , Dweck Marc , Keenan Niall , Magne Julien , Neglia Danilo , Stankovic Ivan 
Published: October 2021

Abstract
Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem will require detailed phenotyping of the contributions of fibrosis, microcirculatory disturbance, abnormal metabolism, and sympathetic innervation, among other mechanisms. For this reason, an imaging strategy for the detection of HF risk needs to not only detect subclinical LV dysfunction (LVD) but also characterize its pathogenesis. At present, it is possible to identify individuals with DM at increased risk HF, and there is evidence that cardioprotection may be of benefit. However, there is insufficient justification for HF screening, because we need stronger evidence of the links between the detection of LVD, treatment, and improved outcome. This review discusses the options for screening for LVD, the potential means of identifying the underlying mechanisms, and the pathways to treatment.
A case report of right ventricular outflow tract obstruction caused by B-cell lymphoma: a rare presentation in an adult patient with pulmonary atresia
Authors: Chatta Payush , Qureashi Mohammad , Plato Steven , Kirk Shannon , Yau David , Kheiwa Ahmed , Parwani Purvi , Razzouk Anees 
Published: October 2021

Abstract

Background
Right ventricle outflow tract (RVOT) dysfunction is a common long-term complication in adult patients with pulmonary atresia/ventricular septal defect (PA/VSD). Common causes include valve thrombosis, stent fractures, and graft calcification. We present, to the best of our knowledge, the first case of malignant invasion of a Gore-Tex conduit, causing severe right ventricle (RV) failure.

Case summary
A 30-year-old woman with a history of PA/VSD with major aortopulmonary collateral arteries (MAPCAs) presented with worsening dyspnoea and exercise intolerance. In infancy, she underwent unifocalization of the right- and left-sided AP collaterals utilizing an 18 and 16 mm Gore-Tex graft, respectively. At age 7, she had surgical repair with VSD patch closure and placement of a 20 mm right ventricle-pulmonary artery (RVPA) homograft connected to a 20 mm Gore-Tex graft with linkage to the previously placed right and left unifocalization grafts. A transthoracic echocardiogram revealed a severely dilated RV and a heavily calcified RVOT conduit with severe stenosis. Cardiac computed tomography showed a stenotic RVPA conduit with calcified mural mass. She underwent surgical revision of the RVPA conduit with thromboendarterectomy of bilateral pulmonary arteries. Pathology of the removed conduit revealed fibrin-associated Epstein–Barr virus-positive diffuse large B-cell lymphoma (FA DLBCL).

Discussion
One prior case report has demonstrated invasion of DLBCL involving an aortic synthetic tube graft. However, malignant invasion of the RVOT Gore-Tex conduit has yet to be reported. Pathological review can be essential in guiding management. Malignant invasion of Gore-Tex conduits is a rare phenomenon, but one that should be closely monitored following repair of the RVOT.
Pericardial effusion in the course of Fabry disease cardiomyopathy: a case report
Authors: Tsuruda Toshihiro , Higashi Yoshimasa , Gi Toshihiro , Nakao Shoichiro 
Published: October 2021

Abstract

Background
Fabry disease (FD) is an X-chromosome-linked inherited disorder of glycosphingolipid metabolism due to deficient or absent lysosomal α-galactosidase A activity.

Case summary
A 51-year-old Japanese woman with a previous diagnosis of FD presented with pericardial effusion. The exudative pericardial fluid contained globotriaosylsphingosine. Left ventricular hypertrophy progressed despite regular administration of agalsidase alfa every 2 weeks over a 7-year period, with increases in plasma levels of globotriaosylsphingosine and interleukin (IL)-18. In addition, the IL-6 level in the pericardial fluid was markedly higher than that in plasma.

Discussion
This case suggests that elevated IL-6 and IL-18 levels in pericardial fluid and plasma indicate the severity of FD cardiomyopathy.
A case report of primary cardiac intimal sarcoma presenting with atrial fibrillation and a left atrial mass
Authors: Ho Karen , Yatham Kavya , Seno Rommel , Sultan Omar 
Published: October 2021

Abstract

Background
Intimal sarcoma is an exceedingly rare type of primary cardiac tumour. It is characterized by poorly differentiated spindle-shaped cells that can mimic smooth muscle and is strongly associated with MDM2 genetic amplification. Owing to its rarity and non-distinctive histological features, diagnosis remains a significant challenge.

Case summary
In this case report, we describe a case of primary cardiac intimal sarcoma in a 37-year-old woman who presented with atrial fibrillation (AF) and a left atrial mass. Despite having a histological sample from an excised left atrial mass, the diagnosis was not made until she presented with back pain secondary to metastatic disease to the spine.

Discussion
Primary cardiac intimal sarcoma is an extremely rare diagnosis. The mainstay management of intimal cardiac sarcoma is aggressive surgical resection. Unfortunately, the prognosis of cardiac sarcomas remains very poor, with a mean survival between 3 months and 1 year. This case of cardiac intimal sarcoma highlights the difficulty in establishing a diagnosis, particularly given the unusual presentation of AF.
A data mining-based cross-industry process for predicting major bleeding in mechanical circulatory support
Authors: Felix Susanne E A , Bagheri Ayoub , Ramjankhan Faiz R , Spruit Marco R , Oberski Daniel , de Jonge Nicolaas , van Laake Linda W , Suyker Willem J L , Asselbergs Folkert W 
Published: October 2021

AbstractAimsOver a third of patients, treated with mechanical circulatory support (MCS) for end-stage heart failure, experience major bleeding. Currently, the prediction of a major bleeding in the near future is difficult because of many contributing factors. Predictive analytics using data mining could help calculating the risk of bleeding; however, its application is generally reserved for experienced researchers on this subject. We propose an easily applicable data mining tool to predict major bleeding in MCS patients.Methods and resultsAll data of electronic health records of MCS patients in the University Medical Centre Utrecht were included. Based on the cross-industry standard process for data mining (CRISP-DM) methodology, an application named Auto-Crisp was developed. Auto-Crisp was used to evaluate the predictive models for a major bleeding in the next 3, 7, and 30 days after the first 30 days post-operatively following MCS implantation. The performance of the predictive models is investigated by the area under the curve (AUC) evaluation measure. In 25.6% of 273 patients, a total of 142 major bleedings occurred during a median follow-up period of 542 [interquartile range (IQR) 205–1044] days. The best predictive models assessed by Auto-Crisp had AUC values of 0.792, 0.788, and 0.776 for bleedings in the next 3, 7, and 30 days, respectively.ConclusionThe Auto-Crisp-based predictive model created in this study had an acceptable performance to predict major bleeding in MCS patients in the near future. However, further validation of the application is needed to evaluate Auto-Crisp in other research projects.
The Josquin canon at 500
Authors: Rodin Jesse 
Published: October 2021

Abstract
No less contentious today than a generation ago, the Josquin canon has sparked confusion since well before the composer’s death. Although modern scholars have repeatedly confronted the problem, until recently it has not been possible to tackle it from the ground up. This essay proposes a practical methodology for doing so. An Appendix classifying music attributed to Josquin by degrees of confidence can serve as a starting point for future research.
Rapid conversion of replicating and integrating Saccharomyces cerevisiae plasmid vectors via Cre recombinase
Authors: Nickerson Daniel P , Quinn Monique A , Milnes Joshua M 
Published: October 2021

Abstract
Plasmid shuttle vectors capable of replication in both Saccharomyces cerevisiae and Escherichia coli and optimized for controlled modification in vitro and in vivo are a key resource supporting yeast as a premier system for genetics research and synthetic biology. We have engineered a series of yeast shuttle vectors optimized for efficient insertion, removal, and substitution of plasmid yeast replication loci, allowing generation of a complete set of integrating, low copy and high copy plasmids via predictable operations as an alternative to traditional subcloning. We demonstrate the utility of this system through modification of replication loci via Cre recombinase, both in vitro and in vivo, and restriction endonuclease treatments.
Genome report: a draft genome of Alliaria petiolata (garlic mustard) as a model system for invasion genetics
Authors: Alabi Nikolay , Wu Yihan , Bossdorf Oliver , Rieseberg Loren H , Colautti Robert I 
Published: October 2021

Abstract
The emerging field of invasion genetics examines the genetic causes and consequences of biological invasions, but few study systems are available that integrate deep ecological knowledge with genomic tools. Here, we report on the de novo assembly and annotation of a genome for the biennial herb Alliaria petiolata (M. Bieb.) Cavara and Grande (Brassicaceae), which is widespread in Eurasia and invasive across much of temperate North America. Our goal was to sequence and annotate a genome to complement resources available from hundreds of published ecological studies, a global field survey, and hundreds of genetic lines maintained in Germany and Canada. We sequenced a genotype (EFCC3-3-20) collected from the native range near Venice, Italy, and sequenced paired-end and mate pair libraries at ∼70 × coverage. A de novo assembly resulted in a highly continuous draft genome (N50 = 121 Mb; L50 = 2) with 99.7% of the 1.1 Gb genome mapping to scaffolds of at least 50 Kb in length. A total of 64,770 predicted genes in the annotated genome include 99% of plant BUSCO genes and 98% of transcriptome reads. Consistent with previous reports of (auto)hexaploidy in western Europe, we found that almost one-third of BUSCO genes (390/1440) mapped to two or more scaffolds despite &lt;2% genome-wide average heterozygosity. The continuity and gene space quality of our draft assembly will enable molecular and functional genomic studies of A. petiolata to address questions relevant to invasion genetics and conservation strategies.
Design synthesis and optimization of a 4-SPS intrinsically compliant parallel wrist rehabilitation robotic orthosis
Authors: Hussain Shahid , Jamwal Prashant K , Van Vliet Paulette 
Published: October 2021

Abstract
Neuroplasticity allows the human nervous system to adapt and relearn motor control following stroke. Rehabilitation therapy, which enhances neuroplasticity, can be made more effective if assisted by robotic tools. In this paper, a novel 4-SPS parallel robot has been developed to provide recovery of wrist movements post-stroke. The novel mechanism presented here was inspired by the forearm anatomy and can provide the rotational degrees of freedom required for all wrist movements. The robot design has been discussed in detail along with the necessary constructional, kinematic, and static analyses. The spatial workspace of the robot is estimated considering various dimensional and application-specific constraints besides checking for singular configurations. The wrist robot has been further evaluated using important performance indices such as condition number, actuator forces, and stiffness. The pneumatic artificial muscles exhibit varying stiffness, and therefore, workspace points are reached with different overall stiffness of the robot. It is essential to assess robot workspace points that can be reached with positive forces in actuators while maintaining a positive definite overall stiffness matrix. After the above analysis, design optimization has been carried out using an evolutionary algorithm whereby three critical criteria are optimized simultaneously for optimal wrist robot design.
The statistical properties of protostellar discs and their dependence on metallicity
Authors: Elsender Daniel , Bate Matthew R 
Published: October 2021

ABSTRACT
We present the analysis of the properties of large samples of protostellar discs formed in four radiation hydrodynamical simulations of star cluster formation. The four calculations have metallicities of 0.01, 0.1, 1, and 3 times solar metallicity. The calculations treat dust and gas temperatures separately and include a thermochemical model of the diffuse interstellar medium. We find that the radii of discs of bound protostellar systems tend to decrease with decreasing metallicity, with the median characteristic radius of discs in the 0.01 and 3 times solar metallicity calculations being ≈20 and ≈65 au, respectively. Disc masses and radii of isolated protostars also tend to decrease with decreasing metallicity. We find that the circumstellar discs and orbits of bound protostellar pairs, and the two spins of the two protostars are all less well aligned with each other with lower metallicity than with higher metallicity. These variations with metallicity are due to increased small-scale fragmentation due to lower opacities and greater cooling rates with lower metallicity, which increase the stellar multiplicity and increase dynamical interactions. We compare the disc masses and radii of protostellar systems from the solar metallicity calculation with recent surveys of discs around Class 0 and I objects in the Orion and Perseus star-forming regions. The masses and radii of the simulated discs have similar distributions to the observed Class 0 and I discs.
Neural Indicator of Altered Mismatch Detection Predicts Atypical Cognitive-Perceptual Experiences in Psychotic Psychopathology
Authors: Pokorny Victor J , Sponheim Scott R 
Published: October 2021

Abstract

Background
Atypical auditory processing (AAP) in psychotic psychopathology is evident in early (N1), mid-latency (P2/N2/mismatch negativity), and late (P3) neural responses. The influence of attention on AAP, and how temporal stages of AAP are associated with phenomenology of psychotic psychopathology are not well understood.

Methods
We used a directed attention oddball task to characterize stages of AAP in psychosis and to examine the influence of selective attention. Ninety patients with schizophrenia (SCZ), 53 patients with bipolar disorder (BP), 90 healthy controls and 72 first-degree relatives of SCZ (SREL) were studied. We used principal components analysis to decompose average-reference 64-channel subject-level ERPs.

Results
Altered attentional modulation was evident in SCZ at early (N1 factor) and late (P3 factor) stages of AAP, but not at mid-latency P2 factor. Irrespective of condition, N1 and P3 were reduced in SCZ, which predicted greater psychopathology and schizotypal personality traits. Diminished mid-latency mismatch detection (P2 factor) was evident in SCZ, BP, and SREL and was associated with greater positive symptoms of psychosis as well as self-reported atypical cognitive-perceptual experiences.

Conclusions
Attentional modulation of early N1, and later P3 neural responses was atypical in patients, but the degree of attentional modulation did not relate to symptom severity or schizotypal traits. Our findings suggest the link between mid-latency mismatch detection and atypical cognitive/perceptual experiences is not driven by attentional deficits alone and point to the promise of mid-latency mismatch detection as a candidate endophenotype and intervention target.
O048 The CF elephant in the adolescent room: a cross sectional study of sleep and mood in adolescents with cystic fibrosis
Authors: Pham H , Ranganathan S , Vandeleur M 
Published: October 2021

Abstract

Background
Mental health issues are of increasing burden within the adolescent CF population, with known impacts from sleep disturbance. There are limited studies examining mediators of this relationship. We aimed to investigate the relationship between sleep quality and mood in adolescents with CF alongside a range potential mediating factors including socioeconomic and family influences in adolescents.

Study Design
Adolescents with CF aged 10–18 and their parents at a Victorian tertiary paediatric CF centre were eligible. Adolescents-parent pairs cross sectionally completed age appropriate online questionnaires assessing sleep (Pediatric Daytime Sleepiness Scale, Sleep Disturbance Scale for Children), mood (Global Anxiety Disorder-7, Patient Health Questionnaire-9, Beck’s Depression Inventory, Brigid Jordan CF screen), health-related quality of life (CF Questionnaire-Revised), family dynamics (Family Assessment Device, Family Management Measure), CF respiratory symptoms (CF Respiratory Symptom Score), and treatment adherence. Socioeconomic status and impacts from pandemic lockdowns were also surveyed.

Progress to date
45 CF adolescents-parent pairs have been recruited. Questionnaires have been distributed and awaiting return of results for analysis.

Intended outcome and impact
We anticipate demonstrating the known association between impaired sleep quality and elevated mood scores. We will also make commentary on associations with a range of social factors (family dynamics, socioeconomic status) as well as parental mental health. Discussion will also include impacts on treatment adherence, HRQOL and respiratory symptom scores. Results from this pilot will inform the upcoming AREST CF prospective longitudinal study where the bidirectional relationships between factors studied can be further explored.
P004 Non-Invasive Ventilation - Partnering with Paediatric NDIS participants and their families
Authors: Angliss M , Leclerc M , Jackman S 
Published: October 2021

Abstract
To discuss a new funding pathway for Non-Invasive ventilation (NIV) in Paediatrics.
Since October 2019, the National Disability Insurance Scheme (NDIS) introduced funding for NDIS participants in the category ‘Disability-related Health Supports - Respiratory Support’.
From August 2020, a nursing project was funded by the Hospital Executive to facilitate the transfer of NIV consumable costs to the NDIS. A retrospective review of 256 NIV patients (Bi-Level Positive Airway Pressure (BiPAP) and Continuous Positive Airway Pressure (CPAP)) and the patients NDIS eligibility status.
110 patients were identified as potential NDIS eligible patients by Primary diagnosis and their families contacted and supported to access NDIS funding for NIV device and consumables. By May 2021, 163 patients were NDIS participants on NIV therapy.
Formal Assistive Technology (Respiratory ventilation) requests were developed with Key stakeholder input and supplier quotes obtained for machines and consumables.
Nursing support, whilst labour intensive has shown to benefit Paediatric patients and their families accessing NDIS funding for NIV therapy in the future. Furthermore, the purchasing of disability-related health supports through NDIS funding is an alternative funding model for NIV in Paediatrics.
P032 Adequate health literacy predicts adherence to continuous positive airway pressure in adults with Obstructive Sleep Apnoea
Authors: Ellender C , Le Feuvre S , Boyde M , Winter S , Duce B , Hukins C 
Published: October 2021

Abstract

Study Objectives
Obstructive sleep apnoea (OSA) is a chronic disease with significant health implications and adequate adherence to continuous positive airway pressure (CPAP) is essential for effective treatment. In many chronic diseases, health literacy has been found to predict treatment adherence and outcomes. In this study, the aim was to determine the health literacy of a sleep clinic population and evaluate the association between health literacy and CPAP adherence.

Methods
A prospective cohort study was undertaken, recruiting 104 consecutive patients with a variety of sleep diagnoses attending the clinic. The Short Form Rapid Estimate of Adult Literacy in Medicine (REALM-SF), a validated questionnaire was administered to measure health literacy. In a sub-group of 91 patients prescribed CPAP for OSA, CPAP usage was measured, with adequate usage defined as greater than 4hrs/night CPAP therapy.

Results
71% of the sleep clinic cohort was found to have adequate health literacy as measured by the REALM-SF. In those prescribed CPAP for OSA, inadequate health literacy was associated with a two fold increase risk for inadequate CPAP usage (adjusted odds ratio 2.75, 95% CI: 1.00 - 7.6, p = 0.05). There was a 1.7hr/night difference in median CPAP usage comparing those with adequate to inadequate health literacy (4.6hrs versus 6.3hrs/night).

Conclusions
The majority of this sleep disorders cohort had adequate health literacy as measured by the REALM-SF questionnaire. However inadequate health literacy appears to be an independent predictor of treatment adherence, and may represent a potentially modifiable risk factor of poor treatment outcomes in OSA.
P040 Night Shift Work and Disease: A Systematic Review of the Role of Oxidative Stress
Authors: Gibson M 
Published: October 2021

Abstract
Night shift workers make up an essential part of the modern workforce. However, night shift workers have higher incidences of late in life diseases and earlier mortality. Night shift workers are exposed to constant light and experience circadian rhythm disruption. Sleep disruption is thought to increase oxidative stress, defined as an imbalance of excess pro-oxidative factors and reactive oxygen species over anti-oxidative activity. Oxidative stress can damage cells, proteins and DNA and can eventually lead to varied chronic diseases such as cancer, diabetes, cardiovascular disease, Alzheimer’s and dementia. This review aimed to understand whether night shift workers were at greater risk of oxidative stress and to contribute to a consensus on this relationship. Twelve studies published in 2001–2019 examining 2,081 workers were included in the review. Studies compared both the impact of working a single shift and in comparisons between those who regularly work night shifts and only day shifts. All studies had evidence to support this relationship across a range of oxidative stress indicators, including: increased DNA damage, reduced DNA repair capacity, increased lipid peroxidation, higher levels of reactive oxygen species, and to a lesser extent, a reduction in antioxidant defence. This research supports the theory that melatonin and the sleep wake cycle mediate the relationship between shift work and oxidative stress. It is concluded that night shift work increases the risk for oxidative stress and therefore future disease. Recommendations are made to promote the long-term health of shift workers considering these findings.