bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON of TSC-2018 and TSC-2007 REGULATIONS for KONYA in TERMS of EQUIVALENT EARTHQUAKE LOAD METHOD
Authors: KOÇER Mustafa , UZUN Mehmet , ÇÖĞÜRCÜ Mustafa Tolga 
Published: August 2021

Earthquake motion is a complex movement that is difficult to understand. It is extremely important to understand and apply the earthquake movement correctly in order to affect the structure.
There are three different methods in the literature for the application and calculation of the earthquake effect to the building. These methods are Equivalent Earthquake Load, Mode Combination and Analysis in Time History. Equivalent earthquake load method comes to the fore due to its ease of application and clarity. In the new earthquake regulation that entered into force in 2019, radical changes were made in the earthquake map used in the Equivalent Earthquake Load method. In this study, two building models with 3 floors and 9 floors were created and Equivalent Earthquake Load analysis was made according to TSC- 2007 and TSC-2018 conditions. Results have been compared with each other.
Network Meta-Analysis of Once Weekly Selinexor-Bortezomib-Dexamethasone in Previously Treated Multiple Myeloma
Authors: Dolph Michael , Tremblay Gabriel , Gilligan Adrienne M , Leong Hoyee 
Published: August 2021

Background: Despite the availability of new treatments, multiple myeloma (MM) is an incurable cancer with nearly all patients relapsing and undergoing multiple lines of treatment. Performing head-to-head comparisons of all treatment options is not feasible. Thus, network meta-analyses play an important role in allowing health-care decision makers to compare the effectiveness of treatment options. Objectives: A Bayesian network meta-analysis (NMA) was developed from studies identified from a systematic literature review (SLR) to evaluate the efficacy of once weekly oral selinexor with once weekly bortezomib and low-dose dexamethasone (XVd) relative to other therapies in previously treated MM. Methods: Ovid was systematically searched for phase 2-3 randomized clinical trials (RCTs) in MM that assessed progression-free survival (PFS), overall survival (OS) and overall response rates (ORR). Two population subsets were assessed: second-line patients (2L) and third-line or greater patients (3L+). Base case results compared all regimens against twice weekly bortezomib and dexamethasone (Vd) as the anchored comparator regimen. Results: Forty-seven RCTs met inclusion. For 2L PFS, OS and ORR, XVd had, on average, out of all iterations, the 6th (out of 21), 4th (out of 15), and 5th (out of 20) best result, respectively, versus Vd. For 3L+ PFS, OS and ORR, XVd had the 12th (out of 24), 11th (out of 22), and 8th (out of 25) best result, respectively, versus Vd. There was no statistically significant difference between XVd and other top-ranking therapies for PFS, OS, and ORR in either 2L and 3L+ except for daratumumab/bortezomib/dexamethasone [DVd], which was favorable versus XVd (2L PFS only). Discussion: Results for XVd were more favorable in 2L, having a higher probability of being a top 5 regimen, compared with 3L+ therapies based on the reported clinical trial results. However, in typical clinical practice, most triplet regimens have been modified using weekly bortezomib dosing, raising questions about the actual efficacy of these regimens versus the reported results using twice weekly bortezomib dosing. Conclusions: The addition of XVd, which was designed with once weekly bortezomib dosing, to the treatment landscape for previously treated MM provides a regimen that may potentially be noninferior to the other top 5 regimens in both 2L and 3L+ settings and is associated with less peripheral neuropathy.
Formation of biocomplexes based on the bacteria Pseudomonas fluorescens and substances of a stimulating nature to limit the development of harmful organisms in potatoes
Authors: Solomiychuk M. 
Published: August 2021

Goal. Selection of combinations of biocomplexes based on Pseudomonas fluorenscens bacteria with stimulant preparations based on various derivatives of ammonium salts of dihydropyrimidine and study of their effectiveness.
Methods. Biotechnological methods for the study of bacteria Pseudomonas fluorenscens strain AR-33. The concentration of viable bacteria (CFU/cm3) was determined by the Koch method. Accounts were performed according to generally accepted methods using experimental methods in phytopathology and plant protection. Determined the effectiveness of drugs at different rates of consumption against fungal diseases.
Results. Derivatives of ammonium salts of dihydropyrimidine did not show a toxic effect on reducing the concentration of viable cells of strain AR-33 bacteria Pseudomonas fluorescens. The best indicators of the weight of 100 seeds and the number of beans in soybean plants showed a combination: Planriz, v.s. (bacteria of strain AR-33 Pseudomonas fluorescens, 3 ќ 10 9 CFU/cm3) (5 l/ha) + 0.1% solution of ximedon + 0.2% solution of succinic acid + 2 ml of DMAE + 2 ml of DMSO. The use of all combinations of biocomplexes showed the effectiveness of drugs against diseases in the range of 59.31—69.63%. With the use of biocomplexes, due to the fungicidal, immunoprotective and stimulating effect, a yield increase of 1.15—1.7 times relative to the control was recorded. The best yield on potatoes (3.4 t/ ha) was provided by the combination Planriz, v.s. (5 l/ha) + 0.1% solution of ximedon + 0.2% solution of succinic acid + 2 ml of DMAE + 2 ml of DMSO. The effectiveness of the drug against late blight was 79.1%.
Conclusions. The use of stimulants and excipients DMAE and DMSO as substances that affect various transmembrane functions, provided an increase in the effectiveness of drugs by 8—14% relative to combinations without their use.
Sistem Keputusan dengan Metode Multi Attribute Utility Theory dalam Penilaian Kinerja Pegawai
Authors: Khair Fuad El , Defit Sarjon , Yuhandri Y 
Published: August 2021

In an agency, it takes an employee who is able to carry out the work in accordance with the objectives in achieving a target becomes an assessment by the leaders. Not only attendance, but also leadership, commitment, cooperation, discipline, service orientation, integrity and ability to perform the task given also need to be used as an indicators . The purposes aim to motivate employees to be passionate in doing every activity and to have a positive influence on their work in facing challenges of globalization. Decision Support System is a need. It is called a Multi Attribute Utility Theory method is a quantitative comparison method that usually combines measurements of different risk costs and benefits. The data processed for employee performance assessment in this study as many as 20 samples sourced from the Population and Civil Registration Office of Pesisir Selatan Regency. This based on several specified criteria and weights. There are 6 data that are used in it. Such as service orientation, integrity, commitment, discipline, cooperation and employee performance goals. The result is able to support employee decisions using predetermined criteria. So that highest value is in the 6th alternative with a value of 1.8 and the lowest value on the 16th alternative with a value of 0. Later it will be a consideration for Population and Civil Registry Office of South Coast Regency to assess its employees in certain period. Employee performance assessment is proven to be able to help the South Coast Population and Civil Registration Office.
The ERP correlates of self-knowledge in ageing
Authors: Tanguay Annick F. N. , Johnen Ann-Kathrin , Markostamou Ioanna , Lambert Rachel , Rudrum Megan , Davidson Patrick S. R. , Renoult Louis 
Published: August 2021

AbstractSelf-knowledge is a type of personal semantic knowledge that concerns one’s self-image and personal identity. It has most often been operationalized as the summary of one’s personality traits (“I am a stubborn person”). Interestingly, recent studies have revealed that the neural correlates of self-knowledge can be dissociated from those of general semantic and episodic memory in young adults. However, studies of “dedifferentiation” or loss of distinctiveness of neural representations in ageing suggest that the neural correlates of self-knowledge might be less distinct from those of semantic and episodic memory in older adults. We investigated this question in an event-related potential (ERP) study with 28 young and 26 older adults while they categorised personality traits for their self-relevance (self-knowledge conditions), and their relevance to certain groups of people (general semantic condition). Participants then performed a recognition test for previously seen traits (episodic condition). The amplitude of the late positive component (LPC), associated with episodic recollection processes, differentiated the self-knowledge, general semantic, and episodic conditions in young adults, but not in older adults. However, in older adults, participants with higher composite episodic memory scores had more differentiated LPC amplitudes across experimental conditions. Moreover, consistent with the fact that age-related neural dedifferentiation may be material and region specific, in both age groups some differences between memory types were observed for the N400 component, associated with semantic processing. Taken together, these findings suggest that declarative memory subtypes are less distinct in ageing, but that the amount of differentiation varies with episodic memory function.
NITAZOXANIDE IN TREATMENT OF ROTAVIRUS DIARRHEA IN CHILDREN: A SINGLE CENTER STUDY
Authors: Aneeqa Adnan  , Abdul Ahad Jamshaid  , Muhammad Azhar Farooq  , Tehreem Fatima  , Syeda sadaf shirazi  , Aqsa Javed  , Muhammad Ahsan Jahangir  
Published: August 2021

BACKGROUND & OBJECTIVE: As Rota virus leads to significant morbidity in children 2 months to 5 years, this study was done to observe the effect of one dose of nitazoxanide on the total duration of rotavirus diarrhea. The primary objective was to evaluate the reduction in the mean duration of viral diarrhea in children after administration of first dose of Nitazoxanide.
METHODLOGY: This descriptive study was done in the Department of Pediatric Medicine Unit I, Mayo Hospital, Lahore from Jan 2016 to June 2016 after approval from the ethical review committee. Sample size calculated was 175 using WHO sample size calculator. Patients of 4–5 years were given 200 mg nitazoxanide twice daily for 3 days; 100 mg nitazoxanide was given twice daily to 12–47 months age group, and patient of <12 months age were given 7.5 mg/kg twice day along with routine care and were followed 12 hourly till the passage of normally formed stools. Duration of diarrhea was recorded.
RESULTS: Out of 175 cases, 58.9% (n=103) were between 2-36 months age while 41.2% (n=72) were 37-60 months age, mean+SD was calculated as 35.06+13.34 months, mean reduction in duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide was recorded as 32.85+2.32 hours.
CONCLUSION: With the use of nitazoxanide along with routine care for rotavirus diarrhea children, the mean duration of rotavirus diarrhea was reported to be less than 1.5 days.
Chemical Complexity of Phosphorous-bearing Species in Various Regions of the Interstellar Medium
Authors: Sil Milan , Srivastav Satyam , Bhat Bratati , Mondal Suman Kumar , Gorai Prasanta , Ghosh Rana , Shimonishi Takashi , Chakrabarti Sandip K. , Sivaraman Bhalamurugan , Pathak Amit , Nakatani Naoki , Furuya Kenji , Das Ankan 
Published: August 2021

Abstract
Phosphorus-related species are not known to be as omnipresent in space as hydrogen, carbon, nitrogen, oxygen, and sulfur-bearing species. Astronomers spotted very few P-bearing molecules in the interstellar medium and circumstellar envelopes. Limited discovery of the P-bearing species imposes severe constraints in modeling the P-chemistry. In this paper, we carry out extensive chemical models to follow the fate of P-bearing species in diffuse clouds, photon-dominated or photodissociation regions (PDRs), and hot cores/corinos. We notice a curious correlation between the abundances of PO and PN and atomic nitrogen. Since N atoms are more abundant in diffuse clouds and PDRs than in the hot core/corino region, PO/PN reflects <1 in diffuse clouds, ≪1 in PDRs, and >1 in the late warm-up evolutionary stage of the hot core/corino regions. During the end of the post-warm-up stage, we obtain PO/PN > 1 for hot core and <1 for its low-mass analog. We employ a radiative transfer model to investigate the transitions of some of the P-bearing species in diffuse cloud and hot core regions and estimate the line profiles. Our study estimates the required integration time to observe these transitions with ground-based and space-based telescopes. We also carry out quantum chemical computation of the infrared features of PH3, along with various impurities. We notice that SO2 overlaps with the PH3 bending-scissoring modes around ∼1000–1100 cm−1. We also find that the presence of CO2 can strongly influence the intensity of the stretching modes around ∼2400 cm−1 of PH3.
An Optimal Estimator of Intrinsic Alignments for Star-forming Galaxies in IllustrisTNG Simulation
Authors: Shi Jingjing , Osato Ken , Kurita Toshiki , Takada Masahiro 
Published: August 2021

Abstract
Emission line galaxies (ELGs), more generally star-forming galaxies, are valuable tracers of large-scale structure and therefore main targets of upcoming wide-area spectroscopic galaxy surveys. We propose a fixed-aperture shape estimator of each ELG for extracting the intrinsic alignment (IA) signal, and assess the performance of the method using image simulations of ELGs generated from the IllustrisTNG simulation including observational effects such as the sky background noise. We show that our method enables a significant detection of the IA power spectrum with the linear-scale coefficient A
IA ≃ (13–15) ± 3.0 up to z = 2, even from the small simulation volume

∼
0.009

(

h

−
1

Gpc
)

3

, in contrast to the null detection with the standard method. Thus the ELG IA signal, measured with our method, opens up opportunities to exploit cosmology and galaxy physics in high-redshift universe.
L’assurance face aux mutations d’un monde de plus en plus risqué
Authors: Trainar Philippe 
Published: August 2021

Le monde change, l’univers des risques s’étend et les conditions d’exercice du métier d’assureur se complexifient. L’assurance qui reflète largement les tensions et les contradictions de son environnement doit s’adapter aux évolutions et aux fluctuations de cet environnement. Face à un métier qui a beaucoup changé tout en conservant de fortes composantes traditionnelles, ils ont été nombreux ceux qui ont annoncé depuis près de dix ans la grande disruption de l’assurance. Mais celle-ci tarde à se concrétiser et les quelques tentatives n’ont finalement guère ébranlé les acteurs traditionnels de l’assurance. Pour autant, ces défis stratégiques forcent l’assurance à s’adapter et à changer en profondeur. Le présent article s’efforce d’identifier plus précisément ces défis stratégiques, d’analyser la capacité du secteur à relever ces défis et de cerner les changements qu’ils vont imposer aux assureurs. Classification JEL : G22, G28, G41, H12, H44, H55, L14, L16, L22
Chapitre 1. Histoire de la médecine et conservation des données médicales des patients
Authors: Comiti Vincent-Pierre 
Published: August 2021

Jusqu’au milieu du XX e siècle la conservation des données médicales se chiffre en kilomètres, pas en mega, terra bits ; leur destruction par milliers de tonnes, pas par effacement informatique. Le rapprochement des données à notre échelle, maintenant informatique, n’est pas inexistant avant environ 1950, mais n’est que manuelle et limitée.
An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity
Authors: Rettig Trisha A , Tan John C , Nishiyama Nina C , Chapes Stephen K , Pecaut Michael J 
Published: August 2021

Abstract
Ab repertoire diversity plays a critical role in the host’s ability to fight pathogens. CDR3 is partially responsible for Ab–Ag binding and is a significant source of diversity in the repertoire. CDR3 diversity is generated during VDJ rearrangement because of gene segment selection, gene segment trimming and splicing, and the addition of nucleotides. We analyzed the Ab repertoire diversity across multiple experiments examining the effects of spaceflight on the Ab repertoire after vaccination. Five datasets from four experiments were analyzed using rank-abundance curves and Shannon indices as measures of diversity. We discovered a trend toward lower diversity as a result of spaceflight but did not find the same decrease in our physiological model of microgravity in either the spleen or bone marrow. However, the bone marrow repertoire showed a reduction in diversity after vaccination. We also detected differences in Shannon indices between experiments and tissues. We did not detect a pattern of CDR3 usage across the experiments. Overall, we were able to find differences in the Ab repertoire diversity across experimental groups and tissues.
Nontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance
Authors: Thofte Oskar , Bettoni Serena , Su Yu-Ching , Thegerström John , Jonsson Sandra , Mattsson Emma , Sandblad Linda , Martí Sara , Garmendia Junkal , Blom Anna M , Riesbeck Kristian 
Published: August 2021

Abstract
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes infections mainly in the upper and lower respiratory tract. The bacterium is associated with bronchitis and exacerbations in patients suffering from chronic obstructive pulmonary disease and frequently causes acute otitis media in preschool children. We have previously demonstrated that the binding of C4b binding protein (C4BP) is important for NTHi complement evasion. In this study, we identified outer membrane protein 5 (P5) of NTHi as a novel ligand of C4BP. Importantly, we observed significantly lower C4BP binding and decreased serum resistance in P5-deficient NTHi mutants. Surface expression of recombinant P5 on Escherichia coli conferred C4BP binding and consequently increased serum resistance. Moreover, P5 expression was positively correlated with C4BP binding in a series of clinical isolates. We revealed higher levels of P5 surface expression and consequently more C4BP binding in isolates from the lower respiratory tract of chronic obstructive pulmonary disease patients and tonsil specimens compared with isolates from the upper respiratory tract and the bloodstream (invasive strains). Our results highlight P5 as an important protein for protecting NTHi against complement-mediated killing.
La praxis pedagógica en la educación física y los estilos de enseñanza predominantes en los docentes de educación básica
Authors: Araujo Mercedes , Campos Mercedes Moraima 
Published: August 2021

El presente estudio tuvo como propósito describir los estilos de enseñanza del docente de Educación Física de la Parroquia Moran. En este se asumió una metodología fenomenológica, que Martínez (2004) la explica en 4 fases. La primera, clarificación de las teorías, creencias y valores. La segunda corresponde a la descripción del fenómeno estudiado lo más auténticamente posible, donde se reflejó la realidad vivida por los sujetos, desde su cotidianidad y experiencia. La tercera fase, se detallan los datos para obtener la interpretación mediante el análisis de contenido y los resultados del mismo. En la cuarta fase se realizó la discusión de los resultados para elaborar las conclusiones y recomendaciones. En esta última fase, se observa que el docente de Educación Física desarrolla una enseñanza directiva centrada en el profesor, basada en la explicación-demostración-repetición y deja de lado la enseñanza integral.
Perspectiva de la mezcla de marketing para la comercialización de queso zarumeño
Authors: Villavicencio Maria Fernanda , Zaruma Jiménez John Kelvin , Gamboa Salcedo Rosalva Beatriz , Sornoza Guerra Mónica Andreina 
Published: August 2021

Objetivo: Analizar el comportamiento del mercado objetivo, para diseñar una guía estratégica basada en el marketing mix, que contribuya de manera eficiente en la comercialización de queso Zarumeño en los cantones de la parte baja de la provincia de El Oro. Método: Investigación con enfoque cuantitativo. Muestreo probabilístico estratificado por afijación proporcional. Resultados: El 62.1% de la población consume lácteos producidos en el cantón Zaruma, de ellos el 86.1% consumen queso zarumeño. La falta de consumo en mayor porcentaje es por inaccesibilidad y ausencia de registro sanitario. Conclusiones: La mezcla de marketing permitirá fortalecer el posicionamiento del producto, su ventaja competitiva y plantear estrategias de comercialización y promoción adecuadas.
Effects of n-3 polyunsaturated fatty acid supplementation on pregnancy outcomes: a systematic review and meta-analysis
Authors: Hao Yingying , Sun Xiaoshi , Wen Ningning , Song Dan , Li Hong 
Published: August 2021

IntroductionThere are limited studies exploring the effects of n-3 PUFA supplementation on pregnancy outcomes. The goal of this study was to review relevant studies in order to determine the effect of n-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on pregnancy outcomes based on eligible randomized controlled trials (RCTs).Material and methodsQualified studies were searched by keywords in PubMed, the Cochrane library and Embase. Studies from other pertinent sources were also reviewed, and RCTs published before January 2021 were reviewed. For each study, we assessed and synthesized the outcomes by relative risk (RR) or weighted mean difference (WMD) combined with 95% confidence interval (95% CI).ResultsWe included 13 studies with 9069 patients. Compared with the control group, n-3 PUFA significantly decreased the incidence of preterm delivery (RR: 0.898, 95%CI: 0.819~0.984) and low birthweight (RR: 0.797, 95%CI: 0.655~0.970); increased the birth weight (WMD: 99.340, 95%CI: 10.503~188.177) and birth length (WMD: 0.449, 95%CI: 0.236~0.663). There was no significant difference in pregnancy-induced hypertension, preeclampsia, intrauterine growth retardation (IUIG), early preterm delivery, anti-hypertensive therapy, gestational diabetes and head circumference at birth between the two groups.ConclusionsThe available evidence shows that n-3 PUFA is not beneficial in reducing the incidence of maternal pregnancy outcomes such as gestational diabetes mellitus and hypertension; but it is beneficial to neonatal health such as decreasing the incidence of preterm delivery and low birthweight and increasing birth weight and birth length.