bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase I/II study of rovalpituzumab tesirine in delta-like 3—expressing advanced solid tumors
Authors: Mansfield Aaron S. , Hong David S. , Hann Christine L. , Farago Anna F. , Beltran Himisha , Waqar Saiama N. , Hendifar Andrew E. , Anthony Lowell B. , Taylor Matthew H. , Bryce Alan H. , Tagawa Scott T. , Lewis Karl , Niu Jiaxin , Chung Christine H. , Cleary James M. , Rossi Michael , Ludwig Carrianne , Valenzuela Ricardo , Luo Yan , Aggarwal Rahul 
Published: August 2021

AbstractDelta-like protein 3 (DLL3) is highly expressed in solid tumors, including neuroendocrine carcinomas/neuroendocrine tumors (NEC/NET). Rovalpituzumab tesirine (Rova-T) is a DLL3-targeting antibody-drug conjugate. Patients with NECs and other advanced DLL3-expressing tumors were enrolled in this phase I/II study (NCT02709889). The primary endpoint was safety. Two hundred patients were enrolled: 101 with NEC/NET (large-cell NEC, gastroenteropancreatic NEC, neuroendocrine prostate cancer, and other NEC/NET) and 99 with other solid tumors (melanoma, medullary thyroid cancer [MTC], glioblastoma, and other). The recommended phase II dose (RP2D) was 0.3 mg/kg every 6 weeks (q6w) for two cycles. At the RP2D, grade 3/4 adverse events included anemia (17%), thrombocytopenia (15%), and elevated aspartate aminotransferase (8%). Responses were confirmed in 15/145 patients (10%) treated at 0.3 mg/kg, including 9/69 patients (13%) with NEC/NET. Rova-T at 0.3 mg/kg q6w had manageable toxicity, with antitumor activity observed in patients with NEC/NET, melanoma, MTC, and glioblastoma.
Critically Appraising Systematic Reviews in the Field of Speech-Language Pathology: A How-to Guide for Clinician Readers
Authors: Donohue Cara , Carnaby Giselle , Garand Kendrea L. (Focht) 
Published: August 2021

PurposeThis tutorial will provide speech-language pathologists with foundational knowledge about systematic reviews and their importance in everyday practice. It will also assist clinicians in developing critical appraisal skills so that current research can be translated judiciously to clinical environments for patient care. Systematic reviews are often regarded as the highest level of research evidence for implementing best evidence-based practice, because they synthesize research findings from multiple high-quality research studies, identify methodological weaknesses and biases from the studies included, and assist in illuminating areas for future research work based on current gaps in the literature. While systematic reviews can provide comprehensive knowledge to inform clinical practice, few speech-language pathologists receive training on appraising and applying the findings from systematic reviews appropriately within clinical settings.ConclusionClinicians within the field of speech-language pathology can use the framework provided in this tutorial to evaluate systematic reviews as a preliminary step for determining appropriate assessment and treatment methods for implementing evidence-based practice within clinical settings.
The Neural Underpinnings of Processing Newly Taught Semantic Information: The Role of Retrieval Practice
Authors: Haebig Eileen , Leonard Laurence B. , Deevy Patricia , Schumaker Jennifer , Karpicke Jeffrey D. , Weber Christine 
Published: August 2021

Purpose
Recent behavioral studies have demonstrated the effectiveness of implementing retrieval practice into learning tasks for children. Such approaches have revealed that repeated spaced retrieval (RSR) is particularly effective in promoting children's learning of word form and meaning information. This study further examines how retrieval practice enhances learning of word meaning information at the behavioral and neural levels.

Method
Twenty typically developing preschool children were taught novel words using an RSR learning schedule for some words and an immediate retrieval (IR) learning schedule for other words. In addition to the label, children were taught two arbitrary semantic features for each item. Following the teaching phase, children's learning was tested using recall tests. In addition, during the 1-week follow-up, children were presented with pictures and an auditory sentence that correctly labeled the item but stated correct or incorrect semantic information. Event-related brain potentials (ERPs) were time locked to the onset of the words noting the semantic feature. Children provided verbal judgments of whether the semantic feature was correctly paired with the item.

Results
Children recalled more labels and semantic features for items that had been taught in the RSR learning schedule relative to the IR learning schedule. ERPs also differentiated the learning schedules. Mismatching label–meaning pairings elicited an N400 and late positive component (LPC) for both learning conditions; however, mismatching RSR pairs elicited an N400 with an earlier onset and an LPC with a longer duration, relative to IR mismatching label–meaning pairings. These ERP timing differences indicated that the children were more efficient in processing words that were taught in the RSR schedule relative to the IR learning schedule.

Conclusions
Spaced retrieval practice promotes learning of both word form and meaning information. The findings lay the necessary groundwork for better understanding of processing newly learned semantic information in preschool children.

Supplemental Material

https://doi.org/10.23641/asha.15063060
Repertorium der Phänomene:Neukonzeption eines vollständig in der Materia medica referenzierten Repertoriums mit phänomenbasierter Struktur und Bayes-Gradierung
Authors: Schäferkordt Rainer 
Published: August 2021

ZusammenfassungDurch die vollständige Analyse der wichtigsten Werke der Materia medica und die Erstellung eines homöopathiespezifischen Thesaurus wurde ein neues Repertorium konzipiert. Neben der phänomenbasierten, dissoziierten Struktur ist es geprägt vom Bayes-Theorem, das die Herausarbeitung des §153-Grundsatzes ermöglicht.
Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression
Authors: Graffunder Adina Sophie , Paisdzior Sarah , Opitz Robert , Renko Kostja , Kühnen Peter , Biebermann Heike 
Published: August 2021

AbstractThe monocarboxylate transporter 8 (MCT8) is a specific thyroid hormone transporter and plays an essential role in fetal development. Inactivating mutations in the MCT8 encoding gene SLC16A2 (solute carrier family 16, member 2) lead to the Allan-Herndon-Dudley syndrome, a condition presenting with severe endocrinological and neurological phenotypes. However, the cellular distribution pattern and dynamic expression profile are still not well known for early human neural development.
Objective Development and characterization of fluorescent MCT8 reporters that would permit live-cell monitoring of MCT8 protein expression in vitro in human induced pluripotent stem cell (hiPSC)-derived cell culture models.
Methods A tetracysteine (TC) motif was introduced into the human MCT8 sequence at four different positions as binding sites for fluorescent biarsenical dyes. Human Embryonic Kidney 293 cells were transfected and stained with fluorescein-arsenical hairpin-binder (FlAsH). Counterstaining with specific MCT8 antibody was performed. Triiodothyronine (T3) uptake was indirectly measured with a T3 responsive luciferase-based reporter gene assay in Madin-Darby Canine Kidney 1 cells for functional characterization.
Results FlAsH staining and antibody counterstaining of all four constructs showed cell membrane expression of all MCT8 constructs. The construct with the tag after the first start codon demonstrated comparable T3 uptake to the MCT8 wildtype.
Conclusion Our data indicate that introduction of a TC-tag directly after the first start codon generates a MCT8 reporter with suitable characteristics for live-cell monitoring of MCT8 expression. One promising future application will be generation of stable hiPSC MCT8 reporter lines to characterize MCT8 expression patterns during in vitro neuronal development.
Dual Drainage of TAPVR—An Exquisite Connection
Authors: Satsangi Amitabh , Singh Dharmraj , Hote M. P. 
Published: August 2021

AbstractDual drainage or double-connection total anomalous pulmonary venous return (TAPVR) is a rare variant in which all four pulmonary veins enter a common venous chamber that then drains into the systemic veins via two or more channels at the supracardiac, cardiac, or infra-cardiac levels. The traditional classification of total anomalous pulmonary venous connection (TAPVC) does not categorize dual drainage separately.We present a case of TAPVR with dual drainage in a 6-year-old child with a rare variety of connection.
Material considerations for the design of 2D/3D hot electron transistors
Authors: Turker Furkan , Rajabpour Siavash , Robinson Joshua A. 
Published: August 2021

Combining two- and three-dimensional (2D/3D) materials provides a unique route to enabling next-generation hot electron transistors (HETs)—a vertical ballistic device, promising for high-frequency applications since they are not limited by electron velocity saturation, fabrication limitations, or short channel effects. The early demonstrations of HETs suffered from poor material and interface qualities and thick device components. The revival of the HET, with a cut-off predicted frequency above 1 THz, can be correlated with the arrival of 2D materials. Here, we discuss HET operating principles, examine HET material architectures with and without tunneling barriers, and review heterostructure considerations. We discuss material and interface properties that control barrier and base performance and critically review recent 2D/3D HETs for tunneling efficiency, output current density, current gain, and output conductance. Finally, we provide an overview of 2D and 3D semiconductors that form Schottky barriers with graphene that may be utilized as a collector while considering the device physics and growth issues.
Reversible oxygen-induced p-doping of mixed-cation halide perovskites
Authors: Shin Dongguen , Zu Fengshuo , Koch Norbert 
Published: August 2021

To fully unlock the potential of metal halide perovskites (MHPs) for use in optoelectronic devices, a comprehensive understanding of their electronic properties is in strong demand but presently lacking. This photoelectron spectroscopy study reveals that the thin films of three important mixed-cation/mixed-halide MHPs behave like intrinsic semiconductors with a very low defect concentration. The Fermi level position in the bandgap can be varied by almost 1 eV by choosing substrates of appropriate work function for samples that were handled under inert conditions. Upon oxygen exposure, two organic/inorganic-cation MHPs become strongly p-doped due to oxygen diffusion into the bulk, a process that is fully reversible when storing the samples in ultrahigh vacuum. In contrast, all-inorganic CsPbI1.8Br1.2 exhibits no electronic property changes upon oxygen exposure. Nonetheless, oxygen is found to effectively remove (light-induced) lead-related surface states of CsPbI1.8Br1.2.
Forgiveness through Writing
Authors: Crowley John Patrick , Denes Amanda , Ponivas Ambyre , Makos Shana , Whitt Joseph 
Published: August 2021

Abstract
Research has identified that writing can help individuals find forgiveness for their romantic partners in the wake of relational transgressions, but little is known about the actual narrative components that bring about changes in forgiveness. The current study sought to investigate the narrative components that contribute to month-long changes in forgiveness for romantic partners who have recently experienced a relational transgression. It also sought to uncover emotional and biological mechanisms that can help account for the associations between narrative components and forgiveness outcomes. The results revealed components of narratives that may both contribute to an increase and decrease in forgiveness over the course of one-month. Additionally, emotional expression and testosterone were identified as potential mediators and moderators of the associations between narrative components and changes in forgiveness.
Absidia corymbifera
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Sarbhoy A. K. 
Published: August 2021

Abstract

A description is provided for
Absidia corymbifera
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: A common saprophyte in soil, compost and vegetable debris but also pathogenic for man and warm-blooded animals (causing mycoses). DISEASES: This species is a common cause of phycomycosis (syn. 'mucormycosis'). Infection in man may involve the central nervous system (RMVM 1, 341), ear (1, 473) or lung (5, 159); see also Dodge (1936), p. 112; Emmons
et al.
(1963), p. 194. In cattle it is a cause of mycotic abortion (Ainsworth & Austwick (1959), p. 53; 4, 507) and has been recorded in the rumen (4, 1850), causing abomasal ulcers (Gitter & Austwick, 1959) and also lymph node infection (3, 134). In the guineapig,
A. corymbifera
can cause an enlargement of the lymph nodes which simulates pseudotuberculosis (2, 1721; Ainsworth & Austwick (1959), p. 48). Infection of mink, fowl (Ainsworth & Austwick (1959), pp. 48-49) and the pig (3, 1249) have been recorded, as has experimental infection of mice (2, 1917). GEOGRAPHICAL DISTRIBUTION: World-wide. TRANSMISSION: Infection occurs from airborne spores which are a characteristic component of the airspora of farm buildings.
Gilbertella persicaria var. indica
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Sarbhoy A. K. 
Published: August 2021

Abstract

A description is provided for
Gilbertella persicaria var. indica
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On pear, tomato, apple, peach,
Thevetia neriifolia
flowers; and also from soil. DISEASE: Causing fruit rot of pear, peach, tomato and apple. GEOGRAPHICAL DISTRIBUTION: Known only from India. TRANSMISSION: By air-borne sporangiospores.
Mucor pusillus
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Sarbhoy A. K. 
Published: August 2021

Abstract

A description is provided for
Mucor pusillus
[Rhizomucor pusillus]
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Common on stored grain and in soil, etc. and also pathogenic for man and animals (causing mycoses). DISEASES: A cause of phycomycosis (syn. 'mucormycosis') in man and animals. Infection of the human lung (RMVM 2, 690), eye (as
Absidia cornealis
Dodge (1936), p. 114) and ear (Dodge (1936), p. 111) have been recorded. Gitter & Austwick (1957) recorded
M. pusillus
associated with bovine abomasal ulcers and it is also a cause of mycotic abortion (Ainsworth & Austwick, 1959, p. 53), Austwick & Venn (4, 1506)). There are also published records of infection of the horse and the pig (see Ainsworth & Austwick, pp. 48, 50) and the harp seal (3, 1664). GEOGRAPHICAL DISTRIBUTION: World-wide. TRANSMISSION: By air-borne spores.
Rhizopus stolonifer
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Sarbhoy A. K. 
Published: August 2021

Abstract

A description is provided for
Rhizopus stolonifer
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On fruits: papaya, plum, strawberry, sweet potato, cotton, groundnuts and in rhizosphere soil of various plants, soil and decaying leaves. DISEASE: Causing fruit rot of plum, Jak fruit (
Artocarpus integrifolia
[Artocarpus integer]
), strawberry ('leak'), peach and a rot of sweet potato (
Ipomoea batatas
) and cotton bolls. GEOGRAPHICAL DISTRIBUTION: World-wide. TRANSMISSION: Air-borne and also by fruit flies,
Drosophila melanogaster
, associated with decaying fruit (RAM 43, 576).
Corynebacterium fascians
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Bradbury J. F. 
Published: August 2021

Abstract

A description is provided for
Corynebacterium fascians
[Rhodococcus fascians]
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On a wide range of hosts; Stapp (40: 584) lists members of 30 genera belonging to 18 families, but only 2 are monocotyledons including pea, chrysanthemum and strawberry. DISEASE: Fasciation of sweet pea, leafy gall of
Chrysanthemum
and other plants. The pathogen induces the development at soil level of many buds or short, thick, distorted stems with misshapen leaves. The outgrowths may superficially resemble galls. Economic losses occur mainly on ornamentals. Cauliflower disease of strawberry is produced by the combined action of this organism and a nematode (38: 218). GEOGRAPHICAL DISTRIBUTION: North America and Northern Europe (CMI Map 426). Some records before 1936 may have been confused with
Agrobacterium tumefaciens
(CMI Descript. 42), which was then thought to cause this disease. TRANSMISSION: The pathogen is soil borne and is also transmitted on the seed coat and on plant cuttings.
Pseudomonas rubrisubalbicans
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Bradbury J. F. 
Published: August 2021

Abstract

A description is provided for
Pseudomonas rubrisubalbicans
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On
Saccharum officinarum
; also produces a limited amount of infection when inoculated into
Sorghum halepense
and
S. vulgare
but, unlike
P. rubrilincans
, it does not affect
Zea mays
. DISEASE: Mottled stripe of sugarcane. Stripes are paler than those of red stripe disease, speckled and often fewer per leaf. No top rot occurs. Of minor economic importance. GEOGRAPHICAL DISTRIBUTION: Apparently less widespread than
P. rubrilineans
. Reported in Africa (Madagascar, Mauritius, Nigeria, Reunion, Tanzania), Asia (Ceylon), Australasia (Fiji, New South Wales, Queensland), Europe (Italy), North America (U.S.A.), Central America (Barbados, Guadelope, Jamaica, Martinique, Nicaragua, Puerto Rico), South America (Brazil, Colombia, Peru). (CMI Map 337). TRANSMISSION: Wind and rain are thought to be the most important factors in spread within fields. It is introduced to new areas in diseased setts.
Glomerella tucumanensis
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Elizabeth J. , Mordue M. 
Published: August 2021

Abstract

A description is provided for
Glomerella tucumanensis
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On
Saccharum officinarum, S. harberi, S. robustum, S. sinense, S. spontaneum, Erianthus giganteus, E. munja
,
Leptochloa dubia, L. filiformis, Sorghum halepense, S. vulgare, S. vulgare
var.
sudanense
. Also on
Narenga
sp. and
Zea mays
on inoculation. DISEASE: Red rot of sugarcane, characterized by the occurrence within the stem of red areas with white centres or flecks and reddening of vascular strands. Attack also occurs on leaf sheath and midrib where small lesions may become confluent. Lesions on the leaf blades normally remain small. GEOGRAPHICAL DISTRIBUTION: Present in almost all sugarcane growing areas. (CMI Map 186) TRANSMISSION: From soil, in infected crop residues; in Louisiana, trash contained perithecia from February to May (42: 486). Ascospores can be dispersed aerially to give rise to secondary infections of the upper nodes; conidia more usually in irrigation water. The fungus may be present in nodes of apparently healthy stock (30: 544) and therefore can be transmitted during propagation.
Septoria socia
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Punithalingam E. 
Published: August 2021

Abstract

A description is provided for
Septoria socia
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On
Chrysanthemum leucanthemum
[Leucanthemum vulgare]
and by inoculation on
Chrysanthemum morifolium, C. maximum, C
.
parthenium, C. segetum
and
Achillea ptarmica
(Punithalingam & Wheeler, 1965). DISEASE: Leaf spot of ox-eye daisy,
C. leucanthemum
. Lesions few, conspicuous on the upper side, rarely confluent, necrotic areas, becoming chocolate brown and later darker or even black, with a reddish purple border, 5 mm across. Lesions are confined to the lower leaves of the plant. Severe infection involving the entire leaf surface during moist conditions causes premature death. GEOGRAPHICAL DISTRIBUTION: Czechoslovakia, Great Britain, Italy, Spain, Pakistan and U.S.S.R. (Literature, Herb. IMI). TRANSMISSION: Not known. It is possible that, like other
Septoria
spp. on
Chrysanthemum
this species may be disseminated by rain-splash and by contact.
Leptosphaeria sacchari
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Morgan-Jones G. 
Published: August 2021

Abstract

A description is provided for
Leptosphaeria sacchari
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On
Saccharum officinarum
. DISEASE: Ring spot of sugarcane leaves. DISTRIBUTION: World-wide (CMI Map 330, 1956). TRANSMISSION: The fungus persists in a viable condition on old dead leaves. Conidia from pycnidia require water droplets for dispersal.
Leptosphaerulina trifolii
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Booth C. , Pirozynski K. A. 
Published: August 2021

Abstract

A description is provided for
Leptosphaerulina trifolii
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Plurivorous but especially on economic plants in the following families:
Cruciferae, Euphorbiaceae, Gramineae
,
Leguminosae
and
Solanaceae
. DISEASE: Leaf spot or pepper spot on account of the numerous small brown to sunken lesions on leaves and petioles of diverse plants, particularly forage legumes. Occasionally larger areas may be involved producing a leaf scorch effect (Yen
et al., J. Agr. For
. (Taiwan) 10: 1-24, 1956). GEOGRAPHICAL DISTRIBUTION: Extremely wide; appears to follow distribution of the numerous hosts. TRANSMISSION: Generally by ascospores which germinate on leaves of host and penetrate directly through cuticle and outer epidermal cell wall. Host tissue appears to be affected by extra-cellular toxin and this has been demonstrated in situ (44, 2831). Infection may also occur via seeds (Carr,
Pl. Path
. 6: 38, 1957).
Nectria galligena
. [Descriptions of Fungi and Bacteria].
Authors: UK, CAB International  , Booth C. 
Published: August 2021

Abstract

A description is provided for
Nectria galligena
. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On apple (
Malus
) and pear (
Pyrus
). It has also been recorded on a large number of other hosts including:
Acer, Betula, Carpinus, Carya, Fagus, Fraxinus, Juglans, Magnolia, Populus, Prunus, Quercus, Salix
and
Sorbus
. DISEASE: Canker, crotch canker (40: 115), crown dieback, storage rot or late storage rot of fruits.
Nectria
eye-rot of fruit on tree. GEOGRAPHICAL DISTRIBUTION: Distribution appears to coincide with the major apple and pear growing areas with the exception of Australia and its probable elimination from Tasmania. (CMI Map 38, Ed. 2, 1963). TRANSMISSION: Conidia spread by rain drops (42: 494; 45, 2689). A high R.H. is essential for ascospore discharge (40: 55; 42: 494), which occurs mainly in spring and autumn. Infection is chiefly by natural wounds, leaf scars (45, 2891), occasionally from the point of attachment of the fruits (42: 691) or from pruning wounds (43, 3250). Early discharge of the ascospores (in temperate regions) increases leaf scar infection and infection in northern temperate regions is most frequent between bud-burst (mid April) and shoot formation (late May) (42: 131).