bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application features‐based virtual machine deployment strategy in cloud environment
Authors: Liu Danxu , Peng Junjie , Zhang Xin , You Yongkang , Ning Bo 
Published: November 2021

AbstractTraditionally virtual machine (VM) deployment is based on one or two resources on the hosts and rarely considers other resources as well as the resource preferences of different applications. This leads to the imbalance and inefficient utilization of the resources on the physical hosts which further results in the waste of the cloud resources. To solve this problem, a novel VM deployment strategy is proposed. In consideration of the features of applications, the strategy deploys VMs based on the resource preferences of applications as well as the remained resources of the hosts. Utilizing the resource preferences the weights of various resources are determined, and the weight tables for VMs are obtained. Combining the resources weights of VMs and the resource configurations of physical hosts the values whether the resources are used in balance are calculated. To verify the correctness and effectiveness of the proposed strategy, extensive experiments were carried out on Cloudsim. Experimental results show that the proposed strategy is correct and effective. It outperforms other algorithms in VM deployment and ensures that the cloud resources are more efficiently utilized.
Boron Coordination Effect in Ni−Nx Doped Graphene Catalysts on the ORR Performance Based on DFT Calculations
Authors: Zhang Jingyu , Cao Da , Liu Hui , Wang Fangqing , Liang Limin , Liu Caichi , Hao Qiuyan , Li Ying 
Published: November 2021

AbstractThe coordination atoms of metal active site in transition metal N‐doped carbon single atom electrocatalysts play a vital role in dominating the catalytic performance of oxygen reduction reaction (ORR) at the cathode of fuel cells or metal‐air cells. In view of weak adsorption ability of Ni active site in NiN4−C catalysts to oxygen intermediate states, herein we introduce boron atoms with smaller electronegativity than N and C atoms to modulate the local coordination environment and electronic structures of Ni site. First‐principles density functional calculations reveal that both B substitution for N atoms (NiN2B2−C) and B coordinating with N and C (NiN4B8−C) can effectively optimize the Gibbs free energy of oxygen intermediate states and hence improve the catalytic activity of the materials. In addition, we propose that the trend change in catalytic activity is mainly governed by the filling of antibonding orbitals between Ni‐3d and O‐2p states near the Fermi level.
Beyond the Molecule: Intermolecular Forces from Gas Liquefaction to X−H⋅⋅⋅π Hydrogen Bonds
Authors: Fabbrizzi Luigi 
Published: November 2021

AbstractInterest toward molecule‐molecule interactions developed during the first half of the 19th century with studies on gas liquefaction. In 1869, Andrews carried out the first accurate study on the effects of temperature and pressure on the behaviour of real gases, and in 1873, van der Waals formulated an equation capable of accounting for critical phenomena of each individual gas The nature of the intermolecular forces responsible for aggregation of gases was investigated in the early 20th century by Keesom and Debye (electrostatic interactions between dipoles) and by London (interaction between instantaneous dipoles, studied by quantum mechanics). The hydrogen bond theory, a particular case of dipolar interaction, originated in the 1920s in Berkeley in the institute directed by G. N. Lewis. Later it was made clear that hydrogen bonding is responsible for the aggregation of most biological systems, from proteins to nucleic acids. This Perspective describes the most significant steps through which the science of intermolecular interactions has progressed over the last two centuries, revisiting classical experiments and theoretical formulations, which led to the complex state of art of today.
Plant breeding increases spring wheat yield potential in Afghanistan
Authors: Sharma Rajiv , Crossa Jose , Ataei Najibeh , Lodin Raqib , Joshi Arun K. , Vargas Mateo , Braun Hans J. , Singh Ravi P. , Bentley A. R. 
Published: November 2021

AbstractWheat (Triticum aestivum L.) is an essential food security crop in Afghanistan. To determine the contribution of wheat breeding to increasing productivity, we analyzed data obtained from 192 trials conducted over 11 locations from 2002–2003 to 2015–2016. Using this data, we estimated annual genetic gains for grain yield, days to heading and plant height over the 14‐yr period. We used best linear unbiased estimates to measure genetic gains across CIMMYT Elite Spring Wheat Yield Trials per se and for the top 5 and top 10% performing genotypes relative to checks. Mean realized genetic gain for grain yield was 115 kg ha–1 yr−1, whereas the top 10 genotypes achieved annual yield gains of 123 kg ha–1. The continually replaced local checks also contributed an annual genetic gain for yield of 107 kg ha–1. The associated adaptive traits days to heading and plant height varied in their response over time with the top 10 yielding genotypes having a 1.82 d annual reduction in heading date while plant height increased by 0.77 cm yr−1 for the same set of genotypes. Results show that continual breeding improvements confer yield gains, contributing to increasing Afghan wheat productivity. This has wider relevance for demonstrating the value of continued investment in public sector plant breeding supporting wheat production and food security in Central Asia.
Incorporation of natriuretic peptides with clinical risk scores to predict heart failure among individuals with dysglycaemia
Authors: Segar Matthew W. , Khan Muhammad Shahzeb , Patel Kershaw V. , Vaduganathan Muthiah , Kannan Vaishnavi , Willett Duwayne , Peterson Eric , Tang W.H. Wilson , Butler Javed , Everett Brendan M. , Fonarow Gregg C. , Wang Thomas J. , McGuire Darren K. , Pandey Ambarish 
Published: November 2021

AbstractAimsTo evaluate the performance of the WATCH‐DM risk score, a clinical risk score for heart failure (HF), in patients with dysglycaemia and in combination with natriuretic peptides (NPs).Methods and resultsAdults with diabetes/pre‐diabetes free of HF at baseline from four cohort studies (ARIC, CHS, FHS, and MESA) were included. The machine learning‐ [WATCH‐DM(ml)] and integer‐based [WATCH‐DM(i)] scores were used to estimate the 5‐year risk of incident HF. Discrimination was assessed by Harrell's concordance index (C‐index) and calibration by the Greenwood–Nam–D'Agostino (GND) statistic. Improvement in model performance with the addition of NP levels was assessed by C‐index and continuous net reclassification improvement (NRI). Of the 8938 participants included, 3554 (39.8%) had diabetes and 432 (4.8%) developed HF within 5 years. The WATCH‐DM(ml) and WATCH‐DM(i) scores demonstrated high discrimination for predicting HF risk among individuals with dysglycaemia (C‐indices = 0.80 and 0.71, respectively), with no evidence of miscalibration (GND P ≥0.10). The C‐index of elevated NP levels alone for predicting incident HF among individuals with dysglycaemia was significantly higher among participants with low/intermediate (<13) vs. high (≥13) WATCH‐DM(i) scores [0.71 (95% confidence interval 0.68–0.74) vs. 0.64 (95% confidence interval 0.61–0.66)]. When NP levels were combined with the WATCH‐DM(i) score, HF risk discrimination improvement and NRI varied across the spectrum of risk with greater improvement observed at low/intermediate risk [WATCH‐DM(i) <13] vs. high risk [WATCH‐DM(i) ≥13] (C‐index = 0.73 vs. 0.71; NRI = 0.45 vs. 0.17).ConclusionThe WATCH‐DM risk score can accurately predict incident HF risk in community‐based individuals with dysglycaemia. The addition of NP levels is associated with greater improvement in the HF risk prediction performance among individuals with low/intermediate risk than those with high risk.
Petrogenesis of mantle peridotite and cumulate peridotite rocks from the Nagaland Ophiolite Complex, NE India
Authors: Ao Aliba , Satyanarayanan Manavalan 
Published: November 2021

Here, we report new geochemical data from mantle peridotite (spinel lherzolite, dunite, and harzburgite) and cumulate peridotite (websterite) rocks from the northernmost portion of the Nagaland Ophiolite Complex. Based on detailed textural, mineral (major element) chemistry, and whole‐rock (major and trace element) chemistry, we reveal the origin of these rocks in different tectonic settings and their modification via the melt–mantle interaction process. The spinel lherzolite rocks with low Cr# (0.16–0.25) chrome spinel are mantle residues formed after low degrees (~10–15%) of partial melting in a mid‐oceanic ridge setting, which has been subsequently modified in a subduction zone setting. However, the dunites and harzburgite samples are interpreted to be depleted mantle residue formed in a supra‐subduction zone (SSZ) setting. Additionally, the dunites are inferred to be of replacive origin representing former harzburgites. Based on Cr# of chrome spinel, the dunites are classified into low Cr# (0.53–0.57), medium Cr# (0.73–0.79), and high Cr# (0.89–0.90) dunites. High Cr# dunite with low‐TiO2 (0.01–0.06 wt%) possibly formed by interaction with a boninitic melt, whereas low‐medium Cr# dunite with high TiO2 (0.14–0.34 wt%) formed by interaction with a high‐Ti melt in an SSZ setting. Harzburgite samples with their highly resorbed orthopyroxene grain boundaries contain chrome spinels (Cr# = 0.84–0.88; TiO2 = 0.00–0.06 wt%) similar to the high Cr# dunite samples and are also interpreted to be formed by interaction with a boninitic melt. The websterite samples with their low Mg# (0.79) olivine and low Ni (345–413 ppm) content are interpreted to be of cumulate origin formed in an SSZ setting. However, the interstitial chrome spinel blebs with low Mg# (0.18–0.19), high Cr# (0.60–0.61), Fe3+ (0.20–0.21), and very high TiO2 (2.03–2.04 wt%) are interpreted to be a result of post‐cumulus interaction of interstitial chrome spinel with high‐Ti intercumulus melt. These mantle peridotites and cumulates of different tectonic origins were obducted and juxtaposed during the final stages of the India‐Asia collision.
Association between marital status and cognitive impairment based on a cross‐sectional study in China
Authors: Chen Zhi‐Chao , Wu Hao , Wang Xiao‐Dan , Zeng Yan , Huang Guowei , Lv Yang , Niu Jianping , Meng Xinling , Cai Pan , Shen Lu , Gang Baozhi , You Yong , Lv Yan , Ren Zhihong , Shi Zhihong , Ji Yong 
Published: November 2021

AbstractBackgroundMarital status may have an impact on the elderly population's health, but few studies in China discussed about the association between marital status and cognitive impairment.ObjectiveTo investigate the relationship between marital status and cognitive impairment. To compare the influences of marital status on dementia between men and women.MethodsThis study was based on a representative national cross‐sectional epidemiological survey in China. We randomly selected 13 provinces and municipalities and included 19,276 participants aged 65 years or older in our study. Data was collected by interviewing the participants about their sociodemographic characteristics, and neuropsychological testing was administered to the participants by neurologists. To analyze the association between marital status and cognitive impairment, multiple logistic regression was based on a series of models.ResultsAmong the 19,276 subjects, about 77.2% were married, 1.6% were single, 21.2% were divorced/separated or widowed. The odds ratios (OR) of dementia were higher in single (OR: 2.13, CI: 1.53–2.97; p < 0.001), divorced/separated/widowed when they were ≤55 years old (OR: 1.75, CI: 1.30–2.35; p < 0.001), and divorced/separated/widowed when they were >55 years old (OR: 1.16, CI: 1.03–1.31; p < 0.001) participants than in married ones. Divorced/separated/widowed ≤55 men had about 2.75 times increase in dementia risk than married men.ConclusionPeople with long‐term divorced/separated/widowed status would be associated to cognitive impairment more than those with short‐term divorced/separated/widowed status. Men may be affected by marriage disruption more than women in terms of increasing the risk of dementia.
FOXC2/ADAM12‐dependent radiosensitivity of head and neck squamous cell carcinoma cells
Authors: Jing Zhibin , Guo Sitong , Li Yao , Liang Zheng 
Published: November 2021

AbstractBackgroundRadiotherapy greatly benefits patients with tumors, but not all patients show favorable treatment response. This study investigated the impact of forkhead box protein C2 (FOXC2)‐mediated a disintegrin and metalloprotease 12 (ADAM12) on the radiosensitivity of head and neck squamous cell carcinoma (HNSCC).MethodsAfter transfection and ionizing radiation, the biological activities of HNSCC cells were assessed. The relationship between ADAM12 and FOXC2 was verified. A xenograft model was used to evaluate the effect of FOXC2 knockdown on HNSCC growth in the context of radiation therapy.ResultsFOXC2 and ADAM12 were upregulated in irradiated CAL‐27 and HN4 cells. Knockdown of FOXC2 suppressed the malignant behaviors of CAL‐27 and HN4 cells and inhibited the growth of transplanted tumors in nude mice. FOXC2 could bind ADAM12 promoter. Overexpression of ADAM12 reversed the promotion of FOXC2 silencing on the radiosensitivity of HNSCC cells.ConclusionsFOXC2 regulates the radiosensitivity of HNSCC by targeting ADAM12.
Role of Hepatocyte‐Derived Osteopontin in Liver Carcinogenesis
Authors: Desert Romain , Ge Xiaodong , Song Zhuolun , Han Hui , Lantvit Daniel , Chen Wei , Das Sukanta , Athavale Dipti , Abraham‐Enachescu Ioana , Blajszczak Chuck , Chen Yu , Musso Orlando , Guzman Grace , Hoshida Yujin , Nieto Natalia 
Published: November 2021

Osteopontin (OPN) expression correlates with tumor progression in many cancers, including hepatocellular carcinoma (HCC); however, its role in the onset of HCC remains unclear. We hypothesized that increased hepatocyte‐derived OPN is a driver of hepatocarcinogenesis. Analysis of a tissue microarray of 366 human samples revealed a continuous increase in OPN expression during hepatocarcinogenesis. In patients with cirrhosis, a transcriptome‐based OPN correlation network was associated with HCC incidence along 10 years of follow‐up, together with messenger RNA (mRNA) signatures of carcinogenesis. After diethylnitrosamine (DEN) injection, mice with conditional overexpression of Opn in hepatocytes (Opn
Hep transgenic [Tg]) showed increased tumor burden. Surprisingly, mice with conditional ablation of Opn in hepatocytes (Opn
ΔHep) expressed a similar phenotype. The acute response to DEN was reduced in Opn
ΔHep, which also showed more cancer stem/progenitor cells (CSCs, CD44+AFP+) at 5 months. CSCs from Opn
Hep Tg mice expressed several mRNA signatures known to promote carcinogenesis, and mRNA signatures from Opn
Hep Tg mice were associated with poor outcome in human HCC patients. Treatment with rOPN had little effect on CSCs, and their progression to HCC was similar in Opn
−/− compared with wild‐type mice. Finally, ablation of Cd44, an OPN receptor, did not reduce tumor burden in Cd44
−/−
Opn
Hep Tg mice. Conclusions: Hepatocyte‐derived OPN acts as a tumor suppressor at physiological levels by controlling the acute response to DEN and the presence of CSCs, while induction of OPN is pro‐tumorigenic. This is primarily due to intracellular events rather that by the secretion of the protein and receptor activation.
The landscape of prognostic and immunological role of myosin light chain 9 (MYL9) in human tumors
Authors: Lv Minghe , Luo Lumeng , Chen Xue 
Published: November 2021

AbstractIntroductionRecent studies have shown that myosin light chain 9 (MYL9) plays a vital role in immune infiltration, tumor invasion, and metastasis; however, the prognostic and immunological role of MYL9 has not been reported. The purpose of this study was to explore the potential prognostic and immunological roles of MYL9 in human cancers by public datasets mainly including the cancer genome atlas (TCGA) and Gene expression omnibus.MethodsThe expression pattern and prognostic value of MYL9 were analyzed across multiple public datasets in different cancer. The correlations between MYL9 expression and immune infiltration among multiple cancers were analyzed by using the TIMER2.0. The MYL9‐related gene enrichment analysis was implemented by mainly using KEGG and GO datasets.ResultsMYL9 was lowly expressed in most cancers, such as breast cancer, lung adenocarcinoma and squamous cell carcinoma, and stomach adenocarcinoma; but it was highly expressed in several cancers, such as cholangiocarcinoma, head and neck squamous cell carcinoma, and liver hepatocellular carcinoma. Furthermore, MYL9 expression was distinctively associated with prognosis in adrenocortical carcinoma, colon adenocarcinoma, brain glioma, lung cancer, ovarian cancer, gastric cancer, breast cancer, blood cancer, and prostate cancer patients. The expressions of MYL9 were significantly associated with the infiltration of cancer‐associated fibroblasts, B cell, CD8+T cell, CD4+T cell, macrophage, neutrophil, dendritic cell in different tumors as well as immune markers. In addition, we found that the functional mechanisms of MYL9 involved muscle contraction and focal adhesion.ConclusionMYL9 can serve as a prognostic signature in pan‐cancer and is associated with immune infiltration. This pan‐cancer study is the first to show a relatively comprehensive understanding of the prognostic and immunological roles of MYL9 across different cancers.
Impact of managerial incentive structure on operating asymmetries and accruals
Authors: Jin Byunghoon 
Published: November 2021

AbstractPrior literature acknowledges that, despite its importance in accounting research and practice, there is little understanding of how accruals (i.e., non‐cash component of earnings) behave. To extend the literature on the complex behavior of accruals, this study examines how the asymmetric behavior of accruals is affected by managerial incentive structure. Built upon the agency theory, this study predicts that the “reverse” asymmetric behavior of accruals (i.e., being more sensitive to sales decreases than to sales increases) is mitigated (amplified) when the incentive structure for CEOs relies relatively more on short‐term cash bonus (long‐term incentives). The empirical results based on a sample of 26,183 firm‐year observations for S&P 1500 companies are highly consistent with the prediction.
Screening for potential quality markers of Callerya nitida var. hirsutissima. Z.Wei based on components profile, pharmacokinetics, and anti‐inflammatory study
Authors: Chen Jingbin , Song Yonggui , Zhou Mingyue , Yang Ming , Zhang Ling , Naeem Abid , Li Zexie , Deng Yaqiong , Liu Yali , Ai Zhifu , Su Dan 
Published: November 2021

AbstractCallerya nitida var. hirsutissima. Z.Wei is a classical, traditional Chinese herbal medicine mostly used to treat rheumatoid arthritis. Recent reports suggest that inconsistent and poor‐quality control levels have primarily affected the therapeutic efficacy. Therefore, the aim of the current study was to investigate the active chemical ingredients, stability of components in blood, pharmacokinetics, and pharmacodynamics to specify the potential markers for quality control and quality evaluation of Callerya nitida. The active components in vitro and in vivo were obtained by ultra‐high‐performance liquid chromatography‐mass spectrometry. Moreover, the changes of the bioactive components in the blood were monitored over time (0–24 h) in order to identify stable active components. On this basis, the pharmacokinetic characteristics of these ingredients combined with the anti‐inflammatory activity were determined to screen out the potential markers for ensuring the quality control of Callerya nitida. The identified four components, such as calycosin, daidzein, formononetin, and 5‐hydroxymethylfurfural, have the characteristics of intrinsic components, clearly defined structures, high exposure values, and in vivo stability, which are important for the therapeutic activity of pharmacologically active materials. Therefore, they can be used as potential markers to control the quality levels of Callerya nitida.
Spatial and Temporal Variation in Annual versus Biennial Reproductive Cycles in Eastern Bering Sea Snow Crab Chionoecetes opilio
Authors: Gardner Jennifer L. , Long W. Christopher , Swiney Katherine M. , Foy Robert J. 
Published: November 2021

Abstract
The stock assessment model currently used for the management of the fishery for snow crab Chionoecetes opilio in the eastern Bering Sea assumes an annual reproductive cycle. However, temperatures below 1°C can extend the snow crab reproductive cycle to 2 years, which could depress the total reproductive potential of the stock. Our objective was to determine the prevalence of snow crab in the eastern Bering Sea on a biennial reproductive cycle, relative to latitudinal and thermal gradients, and evaluate whether available bottom temperature data could be used to predict the proportions of biennial spawners. Mature female snow crab were collected on the annual National Marine Fisheries Service eastern Bering Sea bottom trawl survey during 2014–2018. Bimodality in the frequency distribution of oocyte area suggests that oocyte area can likely be used to distinguish annual and year-1 biennial spawners from year-2 spawners. In 2014, the highest rates of biennial reproduction were found in northern, colder areas in the eastern Bering Sea. In 2015–2018, very low rates of biennial reproduction coincided with warm temperatures across the eastern Bering Sea. This work could help in the estimation of female reproductive potential and allow the development of female-based reference points for the eastern Bering Sea snow crab fishery.
A new development of the scaled boundary finite element method for wave motion in layered half‐space
Authors: Li Zhi‐yuan , Lin Gao , Hu Zhi‐qiang , Ye Wen‐Bin 
Published: November 2021

AbstractThe scaled boundary finite element method (SBFEM) developed by Wolf and Song has shown certain parallels to the finite element method (FEM) and boundary element method (BEM). Because of its semi‐analytical nature, SBFEM is particularly suitable for the analysis of wave propagation in unbounded domains. This paper makes a certain modification of the standard SBFEM. A new idea of scaling surface instead of a scaling center is introduced to formulate the governing SBFE equations for the analysis of wave propagation in multilayered half‐space, which leads to simplifying the modeling and saving considerably the computational effort. In addition, by employing the proposed approach, some problems encountered in engineering practice, which are difficult to deal with by the conventional SBFEM, for example, 3D foundation impedance on half‐space with irregular geographical features, can be effectively solved. The proposed approach also helps to simplify the solution of shell structures. Numerical examples are provided to validate the accuracy and efficiency of the proposed approach.