bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron(II)‐catalyzed Oxidative Coupling of Vicinal Diols and 2‐Amino‐1,4‐naphthoquinone for the Synthesis of Pyrrolonaphthoquinones and Furanonaphthoquinones
Authors: Maity Sujit , Gupta Sandip Kumar , Panda Niranjan 
Published: October 2021

AbstractDirect oxidative coupling of vicinal diols with 2‐aminonaphthoquinones has been studied for the selective synthesis of benzo[f]indole‐4,9‐diones at a moderate temperature. In the presence of an environmentally benign iron catalyst, the vicinal diols were oxidized to α‐hydroxy carbonyl compounds. Subsequently, 2‐amino naphthoquinone reacted with the resultant α‐hydroxy carbonyl compound through tandem N−C and C−C bond formation to afford a vast range of pyrrolonaphthoquinones in remarkable yield. Interestingly, when the 1,2‐propanediol was used, the secondary alcohol group was oxidized preferably by resulting in the 2‐methyl pyrrolonaphthoquinones as the major regioisomer. The synthetic utility of the current strategy was extended for one‐step delivery of natural products, such as 3‐methyl‐1H‐benzo[f]indole‐4,9‐dione (a secondary metabolite isolated from Goniothalamus tapis Miq. with anti‐PAF activity), antibiotic utahmycin B (3‐methyl‐1H‐benzo[f]indole‐4,9‐dione), cytotoxic avicequinone B and anti‐viral FNQ3 (2‐methyl‐naphtho[2,3‐b]furan‐4,9‐dione).
Adiabatic Pumping in a Generalized Aubry–André Model Family with Mobility Edges
Authors: Xing Yan , Qi Lu , Zhao Xuedong , Lü Zhe , Liu Shutian , Zhang Shou , Wang Hong‐Fu 
Published: October 2021

AbstractThe adiabatic pumping between left and right end modes in a generalized Aubry–André model family with mobility edges by resorting to two end–bulk–end channels is investigated. It is shown that the system can be in an intermediate regime mixed with localized and extended phases as the mobility edge is introduced. One of the channels can remain intact even when the parameter determining the localization–delocalization transition exceeds the threshold of the paradigmatic Aubry–André model, leading to that the parametric condition for successful pumping is relaxed. Moreover, it is found that widening the region of the hybrid phase can further enhance the effect of the mobility edge. The pumping result is also quantified based on the fidelity and check the corresponding pumping process to validate these observations. Furthermore, another channel to realize a flexible adiabatic pumping among four types of generalized end modes is engineered. This work enables the potential application of mobility edges in strong–quasidisorder–immune quantum state transfer.
Segregated polylactide/poly(butylene adipate‐co‐terephthalate)/MWCNTsnanocomposites with excellent electrical conductivity and electromagnetic interference shielding
Authors: Liu Yufan , He Hezhi , He Guoshan , Zhao Jianxiong , Yang Yike , Tian Guidong 
Published: October 2021

AbstractAs plastic pollution becomes more serious, we need to find out eco‐friendly materials to alleviate the pollution. Polylactide (PLA) and poly (butylene adipate‐co‐terephthalate) (PBAT) will be one of the most attractive materials to replace those undegradable materials. However, few studies research the segregated conductive PLA/PBAT/MWCNTs nanocomposites. Herein, PLA/PBAT/MWCNTs nanocomposites with the segregated structure were successfully fabricated firstly. The MWCNTs are selectively dispersed in the continuous PBAT phase. The nanocomposite with segregated structure owns excellent electric conductivity. When the content of MWCNTs is 0.41 vol%, the electrical conductivity of composites with segregated structure is 9.43 × 10−4 S/m, which is about 5 orders higher than the nanocomposites without the segregated structure (1.75 × 10−10 S/m). The segregated nanocomposite with 2 wt% (1.18 vol%) MWCNTs owns excellent electromagnetic interference (EMI) of 24 dB, while the ordinary structure of composite is only 17 dB.
Detection of four foodborne pathogens based on magnetic separation multiplex PCR and capillary electrophoresis
Authors: He Shiyu , Huang Yanzhi , Ma Yingwei , Yu Haoyan , Pang Bo , Liu Xingxing , Yin Caihong , Wang Xiaomu , Wei Yuan , Tian Yuling , Zhao Chao , Xu Kun , Wang Juan , Lv Chunping , Song Xiuling , Jin Minghua 
Published: October 2021

AbstractFoodborne pathogen contamination is a major safety issue for many foods and is causing concern worldwide. In this study, a detection system based on magnetic separation, multiplex PCR (MPCR) and capillary electrophoresis (CE) technologies was developed for the simultaneous detection of four foodborne pathogens. Magnetic separation technology is used to rapidly capture pathogenic bacteria in food samples, and then a combination of MPCR and CE can be used to greatly increase detection sensitivity. The detection limit for bacterial DNA reached 10−5–10−7 ng μL−1 and in the analysis of mocked food samples, the assay showed good sensitivity for bacterial detection ranging from 101 to 105 CFU mL−1 with excellent specificity. Compared to similar detection methodologies, this technique avoids the need for time‐consuming enrichment cultures, is more sensitive, and can be used to assay simultaneously four foodborne pathogens.
Circular economy and innovation: A look from the perspective of organizational capabilities
Authors: Sehnem Simone , de Queiroz Adriane A. Farias S. L. , Pereira Susana Carla Farias , dos Santos Correia Gabriel , Kuzma Edson 
Published: October 2021

AbstractStudies of circular economy and innovation have received increasing attention in academic literature in the last quadrennium. They fill a managerial gap on how to operationalise the transition from the linear model to the circular. They show practices, tools and mechanisms that allow creation of business models based on circularity premises. In this article, we seek to identify the intellectual contours of this emerging field, conducting a review of the basic conceptual framework, with an analysis of articles published on the topic of circular economy and innovation. In summary, a systematic literature review was developed, whose final bibliographic portfolio consisted of 94 analysed papers. The results of the study show that eco‐innovation and innovation in business models are highlighted in this field. They are operationalised, mainly, by activating dynamic, relational and absorptive capabilities. The most important innovation practices in this context are waste management, eco‐design business models, product leasing and collaborative commerce. The main contribution of this study is to pave the way for new conceptual developments in organisational capabilities to make transition sustainable and serve as a support arsenal for the maturation of circular economy studies supported by the theory of innovation and also to link management practices to operational processes in the business and production environment favouring the transition to a circular business model. It generates insights for the scientific progression of studies and shows propositions that can be validated in future quantitative studies.
A construction and comprehensive analysis of ceRNA networks and infiltrating immune cells in papillary renal cell carcinoma
Authors: Fan Yaqi , Dai Fangfang , Yuan Mengqin , Wang Feiyan , Wu Nanhui , Xu Mingyuan , Bai Yun , Liu Yeqiang 
Published: October 2021

AbstractBackgroundAs the second most common malignancy in adults, papillary renal cell carcinoma (PRCC) has shown an increasing trend in both incidence and mortality. Effective treatment for advanced metastatic PRCC is still lacking. In this study, we aimed to establish competitive endogenous RNA (ceRNA) networks related to PRCC tumorigenesis, and analyze the specific role of differentially expressed ceRNA components and infiltrating immune cells in tumorigenesis.MethodsCeRNA networks were established to identify the key ceRNAs related to PRCC tumorigenesis based on the 318 samples from The Cancer Genome Atlas database (TCGA), including 285 PRCC and 33 normal control samples. The R package, “CIBERSORT,” was used to evaluate the infiltration of 22 types of immune cells. Then we identified the significant ceRNAs and immune cells, based on which two nomograms were obtained for predicting the prognosis in PRCC patients. Finally, we investigated the co‐expression of PRCC‐specific immune cells and core ceRNAs via Pearson correlation test.ResultsCOL1A1, H19, ITPKB, LDLR, TCF4, and WNK3 were identified as hub genes in ceRNA networks. Four prognostic‐related tumor‐infiltrating immune cells, including T cells CD4 memory resting, Macrophages M1, and Macrophages M2 were revealed. Pearson correlation test indicated that Macrophage M1 was negatively related with COL1A1 (p < 0.01) and LDLR (p < 0.01), while Macrophage M2 was positively related with COL1A1 (p < 0.01), TCF4 (p < 0.01), and H19 (p = 0.032). Two nomograms were conducted with favorable accuracies (area under curve of 1‐year survival: 0.935 and 0.877; 3‐year survival: 0.849 and 0.841; and 5‐year survival: 0.818 and 0.775, respectively).ConclusionThe study constructed two nomograms suited for PRCC prognosis predicting. Moreover, we concluded that H19‐miR‐29c‐3p‐COL1A1 axis might promote the polarization of M2 macrophages and inhibit M1 macrophage activation through Wnt signaling pathway, collaborating to promote PRCC tumorigenesis and lead to poor overall survival of PRCC patients.
Ionic Liquid Modified Electrochemical Capacitor with Long‐Term Performance
Authors: Znaniecki Szymon , Szwabińska Katarzyna , Wojciechowski Jarosław , Skrzypczak Andrzej , Lota Grzegorz 
Published: October 2021

AbstractIonic liquids are used, for example, as corrosion inhibitors for metals, steel, and metal alloys. The method of preventing corrosion through the whole group of these kinds of compounds, called inhibitors, is to use them as additives to aggressive environments, including aqueous electrolytes. In this article, we present the inhibitive effect of imidazolium ionic liquids with 2,5‐dihydroxybenzenesulfonate anion on the corrosion of 316L stainless steel in neutral medium. In addition, we demonstrate that when the ionic liquid is used as an additive to the electrolyte solution (1 M Na2SO4) of a symmetric carbon/carbon electrochemical capacitor with 316L stainless‐steel current collectors, the capacitor lifetime is significantly extended. The ionic‐liquid additive inhibits corrosion of the current collector surface and, in effect, prevents activated carbon porous space from being blocked by corrosion products.
Recovery of Al, Co, Cu, Fe, Mn, and Ni from spent LIBs after Li selective separation by COOL‐Process – Part 2: Solvent Extraction from Sulphate Leaching Solution
Authors: Pavón Sandra , Kaiser Doreen , Bertau Martin 
Published: October 2021

AbstractThe market for lithium‐ion batteries (LIB) is experiencing substantial growth, what is owed to electromobility and the growing demand for cordless devices. Securing the raw material base for LIB is mandatory to achieve the objectives of EU commission's Green Deal. This implies not only sufficient access to lithium but also the accompanying metals, above all Co, Ni, Mn. After preceding recovery of Li2CO3 by the COOL‐Process and subsequent acid digestion of the Li‐free black mass, value metals, such as Co, Cu, Ni, and Mn were recovered by counter‐current solvent extraction. Fe (98.5 ± 0.65 %), Co/Mn (99.8 ± 0.78 %; 99.9 ± 1.11 %), Al (99.7 ± 1.07 %) and Cu/Ni (97.8 ± 1.46 %; 98.6 ± 1.32 %) were selectively extracted with high discriminatory power using cationic exchangers and solvating extractants such as D2EHPA and TBP, respectively. This way, a complete, holistic recycling process for LIB is at hand that allows for recovering housing material, lithium and the accompanying metals almost quantitatively.
Clinical value of pulmonary congestion detection by lung ultrasound in patients with chronic heart failure
Authors: Li Na , Zhu Yunlong , Zeng Jianping 
Published: October 2021

AbstractChronic heart failure is one of the common causes of hospitalization and death. Pulmonary congestion is the common disease feature of patients with chronic heart failure, which could be correctly diagnosed by lung ultrasound. Efficacy of lung ultrasound‐guided pulmonary congestion management for patients with acute heart failure is well documented, however, more evidence is needed to establish the clinical value of pulmonary congestion detection by lung ultrasound examination in patients with chronic heart failure. This review summarized current evidence related to the use and clinical value of pulmonary congestion assessment by lung ultrasound in patients with chronic heart failure, aiming to provide new suggestions on promoting the widespread use of lung ultrasound in patients with chronic heart failure to improve the quality of life and outcome of patients with chronic heart failure.
Amino Acid Based Antimicrobial Agents – Synthesis and Properties
Authors: Nowak Michał G. , Skwarecki Andrzej S. , Milewska Maria J. 
Published: October 2021

AbstractStructures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they are structural analogs of amino acid intermediates of different microbial biosynthetic pathways. Particularly, some aminophosphonate or aminoboronate analogs of protein amino acids are effective enzyme inhibitors, as structural mimics of tetrahedral transition state intermediates. Synthesis of amino acid antimicrobials is a particular challenge, especially in terms of the need for enantioselective methods, including the asymmetric synthesis. All these issues are addressed in this review, summing up the current state‐of‐the‐art and presenting perspectives fur further progress.
Cytomorphologic features of intraductal salivary gland carcinoma: A multi‐institutional study of 13 FNA cases with histologic, molecular, and clinical correlations
Authors: Viswanathan Kartik , Sadow Peter M. , Maleki Zahra , Nishino Michiya , Baloch Zubair W. , Abbott Todd E. , Rao Rema , Faquin William C. 
Published: October 2021

BackgroundIntraductal carcinoma of the salivary gland (IDC) is a rare cancer with potential actionable targets, including RET fusions. Histologic and molecular features of IDC were recently reported, but cytomorphologic data are limited. In the largest multi‐institutional fine‐needle aspiration (FNA) series, the authors describe the cytomorphologic features of 13 IDC cases with available clinical, radiologic, histopathologic, and molecular data.MethodsThe cases included 13 FNAs for 9 low‐grade (LG) IDCs and 4 high‐grade (HG) IDCs with corresponding histopathology and available molecular, imaging, and clinical data. Smears and liquid‐based preparations available for 12 FNAs were semiquantitatively scored for key cytomorphologic findings and correlated with the corresponding resection.ResultsLG IDC FNAs showed a cellular, biphasic population of large, atypical ductal cells with mildly pleomorphic nuclei in a clean background and a minor population of small, uniform myoepithelial cells. In contrast, all HG IDC FNAs showed predominantly ductal cells with marked nuclear pleomorphism, coarse chromatin, and necrosis. With the Milan system, most LG and HG IDC FNAs were classified as either salivary gland neoplasms of uncertain malignant potential (54%) or malignant (31%). Immunohistochemistry showed ductal epithelial reactivity with mammaglobin, androgen receptor, and S100, whereas myoepithelial cells were positive for p63 and/or calponin. Among cases with next‐generation sequencing, 4 LG IDCs showed NCOA4‐RET gene fusions, whereas an HG IDC showed HRAS and PIK3CA mutations.ConclusionsThe cytomorphology of IDC overlaps with other benign and malignant salivary gland neoplasms. Immunohistochemistry limits the differential diagnosis, but definitive classification requires molecular analysis. A diagnosis of IDC has potential implications for patient management.
Non‐suicidal self‐injury in US military veterans: Results from the National Health and Resilience in Veterans Study
Authors: Kachadourian Lorig K. , Nichter Brandon , Herzog Sarah , Norman Sonya B. , Sullivan Tami , Pietrzak Robert H. 
Published: October 2021

AbstractBackgroundTo evaluate the prevalence of lifetime non‐suicidal self‐injury (NSSI) among US military veterans and identify sociodemographic, military, psychiatric and clinical correlates associated with NSSI.MethodsData were analysed from the 2019–2020 National Health and Resilience in Veterans Study, a contemporary, nationally representative survey of 4069 US veterans. Outcomes measured included lifetime history of NSSI, trauma history, lifetime and current DSM‐V mental disorders and lifetime and recent suicidal behaviours.ResultsThe overall prevalence of lifetime NSSI was 4.2% (95% confidence interval [3.6%, 4.9%]). Multivariable analyses revealed that veterans who endorsed lifetime NSSI were more likely to be younger, female, non‐Caucasian, unmarried or unpartnered, and to have a lower annual household income. Veterans who endorsed lifetime NSSI reported more adverse childhood experiences and lifetime traumas and were more likely to have experienced military sexual trauma. They also were more likely to screen positive for lifetime posttraumatic stress disorder, major depressive disorder (MDD) and substance use disorders and to have attempted suicide. Finally, lifetime NSSI was associated with current MDD, generalized anxiety disorder, and substance use disorders, as well as past‐year suicidal ideation.ConclusionResults of this study provide the first‐known data on the epidemiology of NSSI in US military veterans. They suggest that certain correlates can help identify veterans who may be at greater risk for engaging in NSSI, as well as the potential prognostic utility of lifetime NSSI in predicting current psychiatric problems and suicide risk in this population.
Nutritional status during hospitalization is associated with the long‐term prognosis of patients with heart failure
Authors: Takada Takuma , Jujo Kentaro , Inagaki Keiko , Abe Takuro , Kishihara Makoto , Shirotani Shota , Endo Nana , Watanabe Shonosuke , Suzuki Kazuhito , Minami Yuichiro , Hagiwara Nobuhisa 
Published: October 2021

AbstractAimsThe CONtrolling NUTritional status (CONUT) score represents the nutritional status of patients with heart failure (HF). Although high CONUT scores on admission are associated with increased risks of cardiovascular (CV) events in patients with HF, the impact of CONUT changes during hospitalization on their long‐term prognosis is unclear. This study aimed to investigate the impact of CONUT score changes on the clinical outcomes of patients with HF after discharge.Methods and resultsThis observational study included 1705 patients hospitalized with HF who were discharged alive. The patients were categorized depending on their CONUT scores at admission and discharge into persistently high, high at admission and normal at discharge, normal at admission and high at discharge, and persistently normal CONUT groups. The primary endpoint was a composite of CV death and readmission for HF after discharge. The primary endpoint occurred in 652 patients (38%) during the median 525 day follow‐up period. Patients with persistently high CONUT scores had the highest composite endpoint rate (log‐rank trend test: P < 0.001). After adjusting for covariates, the hazard ratio for the composite outcome was significantly lower for the patients with high CONUT scores at admission and normal CONUT scores at discharge than that for those with persistently high CONUT scores (hazard ratio: 0.69; 95% confidence interval: 0.49–0.98).ConclusionsNutritional status changes in patients with HF that occurred during hospitalization were associated with CV events after discharge. Improving the nutritional status of patients may improve their clinical outcomes.
β‐Keto Amides: A Jack‐of‐All‐Trades Building Block in Organic Chemistry
Authors: Li Wanfang , Zheng Yan , Qu Erdong , Bai Jin , Deng Qinyue 
Published: October 2021

Abstractβ‐Keto amides are a versatile class of compounds that find wide applications in organic chemistry owing to the juxtaposition of multiple reaction sites within their molecular structures. Due to the importance of β‐keto amides in modern organic chemistry, numerous novel preparation methods, synthetic applications and unprecedented reactivities have been recorded over the past decade. Taking advantage of transition‐metal‐catalysis and organocatalysis, β‐keto amides have emerged into a jack‐of‐all‐trades building block for many stereoselective or tandemized multicomponent reactions. But so far, no reviews have been documented on these recent achievements with β‐keto amides. Our Review aims to provide a thorough summary regarding: (a) the synthesis of β‐keto amides, (b) the reactivities of β‐keto amides, (c) the synthetic applications of β‐keto amides in various important heterocyclic compounds, and (d) the coordination of β‐keto amides with main group elements and transition metals and the relevant applications.
Twin‐model framework development for a comprehensive battery lifetime prediction validated with a realistic driving profile
Authors: Hosen Md Sazzad , Kalogiannis Theodoros , Youssef Rekabra , Karimi Danial , Behi Hamidreza , Jin Lu , Van Mierlo Joeri , Berecibar Maitane 
Published: October 2021

AbstractLithium‐ion technologies have become the most attractive and selected choice for battery electric vehicles. However, the understanding of battery aging is still a complex and nonlinear experience which is critical to the modeling methodologies. In this work, a comprehensive lifetime modeling twin framework following semi‐empirical methodology has been developed to predict the crucial degradation outputs accurately in terms of capacity fade and resistance increase. The constructed model considers all the relevant aging influential factors for commercial nickel manganese cobalt (NMC) Li‐ion cells based on long‐term laboratory‐level investigation and combines both the cycle life and the calendar life aspects. To demonstrate robustness, the model is validated with a real‐life worldwide harmonized light‐duty test cycle (WLTC). The model can precisely predict the capacity fade and the internal resistance growth with a root‐mean‐squared error (RMSE) of 1.31% and 0.56%, respectively. The developed model can be used as an advanced online tool forecasting the lifetime based on dynamic profiles.
Alternative seismische Quellen für die Vorauserkundung im konventionellen Tunnelbau
Authors: Hartl Irene , Schlögel Ingrid , Behm Michael , Wenighofer Robert , Galler Robert 
Published: October 2021

AbstractFor seismic ahead‐of‐the‐face prediction in tunnelling, sources with known properties are usually used, which, however, are not compatible with NATM. In order to integrate geophysical exploration into conventional tunnelling, the feasibility of construction machinery for generating seismic source signals was investigated. Passive monitoring during conventional tunnelling was used to analyse the seismic signals. Different radiation characteristics of drilling, blasting and bouldering could be identified and their characteristics regarding range and spectrum of the signal could be determined. In subsequent system tests, various machines used in NATM tunnelling were examined for their suitability as sources. The sensor positioning for source signal pickup was evaluated by stroke tests and during ongoing tunnelling operations. For the registration of the waves in the rock mass, different receivers with different geometries were used to characterize the wave field emitted to the front or side of the sources. In addition, the necessary processing steps were determined in order to make these signals usable for an ahead‐of‐the‐face exploration. The results and data form a basis for further development into a practical technical solution for conventional tunnel construction.