bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of paper-based and web-based food frequency questionnaires for 7-year-old children in Singapore
Authors: Lai Jun S. , Loh Jason , Toh Jia Ying , Sugianto Ray , Colega Marjorelee , Tan Kok Hian , Yap Fabian Kok Peng , Chong Yap-Seng , Godfrey Keith M. , Chong Mary Foong-Fong 
Published: November 2021

AbstractAdvances in technology enabled the development of a web-based, pictorial FFQ to collect parent-report dietary intakes of 7-year-old children in the Growing Up in Singapore Towards healthy Outcomes study. This study aimed to compare intakes estimated from a paper-FFQ and a web-FFQ and examine the relative validity of both FFQ against 3-d diet records (3DDR). Ninety-two mothers reported food intakes of their 7-year-old child on a paper-FFQ, a web-FFQ and a 3DDR. A usability questionnaire collected participants’ feedback on the web-FFQ. Correlations and agreement in energy, nutrients and food groups intakes between the dietary assessments were evaluated using Pearson’s correlation, Lin’s concordance, Bland–Altman plots, Cohen’s κ and tertile classification. The paper- and web-FFQ had good correlations (≥ 0·50) and acceptable-good agreement (Lin’s concordance ≥ 0·30; Cohen’s κ ≥ 0·41; ≥ 50 % correct and ≤ 10 % misclassification into same or extreme tertiles). Compared with 3DDR, both FFQ showed poor agreement (< 0·30) in assessing absolute intakes except micronutrients (web-FFQ had acceptable-good agreement), but showed acceptable-good ability to classify children into tertiles (κ ≥ 0·21; ≥ 40 % and ≤ 15 % correct or misclassification). Bland–Altman plots suggest good agreement between web-FFQ and 3DDR in assessing micronutrients and several food groups. The web-FFQ was well-received, and majority (81 %) preferred the web-FFQ over the paper-FFQ. The newly developed web-FFQ produced intake estimates comparable to the paper-FFQ, has acceptable-good agreement with 3DDR in assessing absolute micronutrients intakes and has acceptable-good ability to classify children according to categories of intakes. The positive acceptance of the web-FFQ makes it a feasible tool for future dietary data collection.
Relationship between water iodine and children’s goiters
Authors: An Shuli , Fan Lijun , Li Ming , Wang ZhengYuan , Liu Shoujun , Ji YuTong , Liu Xiang Li , Du Yang , Meng Fangang , Liu Peng 
Published: November 2021

AbstractExcessive iodine can lead to goiters. However, the relationship between the water iodine concentration (WIC) and goiter rate (GR) is unclear. This study aims to explore the factors that influence children’s GR in areas with high WIC and analyse the threshold value of the GR increase associated with the WIC. According to the monitoring of the areas with high WIC in China in 2018–2020, a total of 54 050 children in eight high water iodine provinces were chosen. Drinking water, urine and edible salt samples of children were collected. The thyroid volume (Tvol) was measured. A generalised additive model (GAM) was used to analyse the relationship between the WIC and GR in children. Among the 54 050 children in areas with high WIC, the overall GR was 3·34 %, the median of water iodine concentration was 127·0 µg/l, the median of urinary iodine concentration was 318 µg/l and the non-iodised salt coverage rate (NISCR) was 63·51 %. According to the GAM analysis results, water iodine and urinary iodine are factors that influence the Tvol and GR, while the NISCR affects only the GR. When the WIC was more than 420 µg/l or the urinary iodine concentration was more than 800 µg/l, the GR increased rapidly. When the NISCR reached more than 85 %, the GR was the lowest. Thus, in areas with high WIC, WIC more than 420 µg/l may increase the risk of goiter, and the NISCR should be increased to over 85 % to avoid goiters in children.
Do Social Networks Facilitate Informed Option Trading? Evidence from Alumni Reunion Networks
Authors: Cheong Harvey , Kim Joon Ho , Münkel Florian , Spilker Harold D. 
Published: November 2021

AbstractMaterial private information transmits through social networks. Using manually collected information on networks of alumni reunion cohorts, we show that hedge fund managers connected to directors of firms engaged in merger deals increase call-option holdings on target firms before deal announcements. Effects are larger when reunion events for connected cohorts occur just before announcements. Independent directors, directors with short tenure, and directors with low stock ownership are more likely to transmit information. Our results are robust to confounding factors and alternative specifications. These findings highlight the role of social networks as channels of private-information dissemination.
Declining citation accuracy in polar research
Authors: McIntyre T. , Haussmann N.S. 
Published: November 2021

Abstract
Accurate citation practices are important to ensure a robust knowledge base and overall trustworthy academic enterprise. The prevalence of poor citation practices has been assessed in multiple fields, resulting in estimates of inaccurate citations ranging typically between 15% and 25%. Here, we assessed the accuracy of citations in research articles extracted from 11 journals with a polar sciences focus. Thirty percent of citations from recent articles (published between 2018 and 2019) and 26 % of citations between 1980 and 2019 were found to be inaccurate. We found no evidence for differences in citation accuracy between the journals assessed, or effects on citation accuracy associated with the number of authors, number of references, position of references or if a citation was a self-citation or not. Importantly, we present evidence for a decline in citation accuracy between 1980 and 2019 in polar sciences. Citation practices are unlikely to improve unless journals provide incentives for scholars to be more meticulous, and we recommend active monitoring of citation accuracy and citation appropriateness by reviewers and editorial staff.
The transformative power of accepting God's love
Authors: Byerly T. Ryan 
Published: November 2021

AbstractThis article develops an account of some of the central features involved on the human side in adopting a richly accepting orientation towards God's love. It then builds a conceptual and empirical argument for the conclusion that accepting God's love can enhance a person's mental health and can indirectly enable a person to cultivate or maintain moral virtues – whether or not God exists. Importantly, the article contends that these transformative benefits are available to both believers and agnostics, and an original secondary data analysis is offered to support this conclusion in the case of agnostics. The article explains how this transformative value of accepting God's love may serve as the basis for a novel pragmatic argument for theistic religious commitment.
Bureaucratic Shirking in China: Is Sanction-based Accountability a Cure?
Authors: Tu Wenyan , Gong Ting 
Published: November 2021

AbstractThis study analyses the intricate relationship between sanction-based accountability and bureaucratic shirking. Drawing on an original survey conducted among Chinese civil servants, it addresses the question of whether sanction-based accountability can effectively regulate the conduct of public officials and provide a cure for bureaucratic shirking. The study identifies the characteristics of shirking behaviour in the Chinese bureaucracy and distinguishes three major patterns: evading responsibility, shifting responsibility and reframing responsibility. The findings indicate that sanction-based accountability may contain some obvious and notorious slacking types of behaviour, such as stalling and inaction, but government officials may distort or reframe their responsibilities to cope with accountability pressure. Empirical evidence suggests that owing to some “strategic” adjustments in bureaucratic behaviour, flagrant shirking is replaced by more subtle ways of blame avoidance, such as playing it safe or fabricating performance information. Sanction-based accountability therefore does not offer a panacea for bureaucratic shirking.
Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood
Authors: Vrantsidis Daphne M. , Clark Caron A.C. , Volk Auriele , Wakschlag Lauren S. , Andrews Espy Kimberly , Wiebe Sandra A. 
Published: November 2021

AbstractChild genotype is an important biologically based individual difference conferring differential sensitivity to the effect of parental behavior. This study explored dopaminergic polygenic composite×parental behavior interactions in relation to young children’s executive function. Participants were 135 36-month-old children and their mothers drawn from a prospective cohort followed longitudinally from pregnancy. A polygenic composite was created based on the number ofCOMT, DAT1,DRD2, andDRD4alleles associated with increased reward sensitivity children carried. Maternal negative reactivity and responsiveness were coded during a series of structured mother–child interactions. Executive function was operationalized as self-control and working memory/inhibitory control. Path analysis supported a polygenic composite by negative reactivity interaction for self-control. The nature of the interaction was one of diathesis-stress, such that higher negative reactivity was associated with poorer self-control for children with higher polygenic composite scores. This result suggests that children with a higher number of alleles may be more vulnerable to the negative effect of negative reactivity. Negative reactivity may increase the risk for developing behavior problems in this population via an association with poorer self-control. Due to the small sample size, these initial findings should be treated with caution until they are replicated in a larger independent sample.
A focused linear logical framework and its application to metatheory of object logics
Authors: Felty Amy , Olarte Carlos , Xavier Bruno 
Published: November 2021

AbstractLinear logic (LL) has been used as a foundation (and inspiration) for the development of programming languages, logical frameworks, and models for concurrency. LL’s cut-elimination and the completeness of focusing are two of its fundamental properties that have been exploited in such applications. This paper formalizes the proof of cut-elimination for focused LL. For that, we propose a set of five cut-rules that allows us to prove cut-elimination directly on the focused system. We also encode the inference rules of other logics as LL theories and formalize the necessary conditions for those logics to have cut-elimination. We then obtain, for free, cut-elimination for first-order classical, intuitionistic, and variants of LL. We also use the LL metatheory to formalize the relative completeness of natural deduction and sequent calculus in first-order minimal logic. Hence, we propose a framework that can be used to formalize fundamental properties of logical systems specified as LL theories.
The effect of central bank credibility on forward guidance in an estimated New Keynesian model
Authors: Cole Stephen J. , Martínez-García Enrique 
Published: November 2021

AbstractThis paper examines the effectiveness of forward guidance shocks in the US. We estimate a New Keynesian model with imperfect central bank credibility and heterogeneous expectations using Bayesian methods and survey data from the Survey of Professional Forecasters (SPF). The results provide important takeaways: (1) The estimated credibility of the Fed’s forward guidance announcements is relatively high, but anticipation effects are attenuated. Accordingly, output and inflation do not respond as favorably as in the fully credible counterfactual. (2) The so-called “forward guidance puzzle” arises partly from the unrealistically large responses of macroeconomic variables to forward guidance under perfect credibility and homogeneous fully informed rational expectations, assumptions which are found to be jointly inconsistent with the observed US data. (3) Imperfect credibility provides a plausible explanation for the empirical evidence of forecasting error predictability based on forecasting disagreement found in the SPF data. Thus, we show that accounting for imperfect credibility and forecasting disagreements is important to understand the formation of expectations and the transmission mechanism of forward guidance.
The intimate labour of internationalism: maternalist humanitarians and the mid-twentieth century family planning movement
Authors: Bourbonnais Nicole C. 
Published: November 2021

AbstractThis article moves past high politics and the most prominent activists to explore the daily, intimate practice of international movement building by mid-level fieldworkers within the International Planned Parenthood Federation (IPPF) during its first decade of existence (1952–62). It illustrates how fieldworkers and the IPPF’s practitioner-oriented newsletter Around the World attempted to bridge the ideological and geographic diversity of the family planning movement and connect with advocates around the world through an emotive narrative of suffering, love, and global humanity, reinforced by affective bonds and women’s volunteerism. The story of global family planning must thus be seen not only as part of the history of eugenics, population control, and feminism, but also as part of the longer trajectory of maternalist humanitarianism. This mid-twentieth century version of maternalist humanitarianism built on earlier traditions but also incorporated concepts of human rights, critiques of dominant gender and sexual norms, and an official commitment to local self-determination in the context of decolonization movements. Still, the organization was plagued by the problems that shape humanitarianism more broadly, including the difficulty of moving past colonialist discourses, deeply rooted feelings of racial superiority, and the contradictions inherent in attempts to impose an impossible ideal of political neutrality in a politically complex world. Looking at the history of global family planning from this perspective thus helps us understand how the different traditions, intimate relationships, and practical experiences mid-level actors bring to their work shape the broader process of international movement building, beyond high-level political and ideological activism.
Supplemental folic acid and/or multivitamins in pregnancy is associated with a decreased risk of childhood and adolescent nasopharyngeal carcinoma
Authors: Yan Yue , Xie Chuanbo , Di Shi , Wang Zhonghao , Wu Minqing , Li Yanhong , Liu Yuying , Jiang Rou 
Published: November 2021

AbstractThe aim of this study was to evaluate the association between prenatal and neonatal period exposures and the risk of childhood and adolescent nasopharyngeal carcinoma (NPC). From January 2009 to January 2016, a total of 46 patients with childhood and adolescent NPC (i.e., less than 18 years of age) who were treated at Sun Yat-sen University Cancer Center were screened as cases, and a total of 45 cancer-free patients who were treated at Sun Yat-sen University Zhongshan Ophthalmic Center were selected as controls. The association between maternal exposures during pregnancy and obstetric variables and the risk of childhood and adolescent NPC was evaluated using logistic regression analysis. Univariate analysis revealed that compared to children and adolescents without a family history of cancer, those with a family history of cancer had a significantly higher risk of childhood and adolescent NPC [odds ratios (OR) = 3.15, 95% confidence interval (CI) = 1.02–9.75, P = 0.046], and the maternal use of folic acid and/or multivitamins during pregnancy was associated with a reduced risk of childhood and adolescent NPC in the offspring (OR = 0.07, 95% CI = 0.02–0.25, P < 0.001). After multivariate analysis, only the maternal use of folic acid and/or multivitamins during pregnancy remained statistically significant. These findings suggest that maternal consumption of folic acid and/or multivitamins during pregnancy is associated with a decreased risk of childhood and adolescent NPC in the offspring.
Seasonal Variability in Local Carbon Dioxide Biomass Burning Sources Over Central and Eastern US Using Airborne In Situ Enhancement Ratios
Authors: DiGangi Joshua P. , Choi Yonghoon , Nowak John B. , Halliday Hannah S. , Diskin Glenn S. , Feng Sha , Barkley Zachary R. , Lauvaux Thomas , Pal Sandip , Davis Kenneth J. , Baier Bianca C. , Sweeney Colm 
Published: November 2021

AbstractWe present observations of local enhancements in carbon dioxide (CO2) from local emissions sources over three eastern US regions during four deployments of the Atmospheric Carbon Transport‐America (ACT‐America) campaign between summer 2016 and spring 2018. Local CO2 emissions were characterized by carbon monoxide (CO) to CO2 enhancement ratios (i.e., ΔCO/ΔCO2) in air mass mixing observed during aircraft transects within the planetary boundary layer. By analyzing regional‐scale variability of CO2 enhancements as a function of ΔCO/ΔCO2 enhancement ratios, observed relative contributions to CO2 emissions were separated into fossil fuel and biomass burning (BB) regimes across regions and seasons. CO2 emission contributions attributed to biomass burning (ΔCO/ΔCO2 > 4%) were negligible during summer and fall in all regions but climbed to ∼9%–11% of observed combustion contributions in the South during winter and spring. Relative CO2 fire emission trends matched observed winter and spring BB contributions, but conflictingly predicted similar levels of BB during the fall. Satellite fire data from MODIS and VIIRS suggested the use of higher spatial resolution fire data that might improve modeled BB emissions but were not able to explain the bulk of the discrepancy.
Dynamic Rupture Simulations of the 2008 7.9 Wenchuan Earthquake: Implication for Heterogeneous Initial Stress and Complex Multifault Geometry
Authors: Tang Rongjiang , Zhu Shoubiao , Gan Lu 
Published: November 2021

AbstractThe 2008 Mw7.9 Wenchuan earthquake ruptured northwest‐dipping imbricate oblique reverse faults along the Longmenshan thrust belt at the eastern margin of the Tibetan Plateau, and developed one of the most complex coseismic rupture patterns for reverse faulting events ever reported in intraplate settings. To evaluate to what extent complex fault geometry and heterogeneities in initial stress can explain the characteristics of coseismic observations, we simulate spontaneous dynamic rupture propagation governed by slip‐weakening friction law on the geometrically complex multifault system loaded by heterogeneous stress. Our model reproduces many observed features including the multifault ruptures, locations of the maximum slip, Interferometric Synthetic Aperture Radar observations, source time functions and peak ground velocities. Our results suggest that the maximum horizontal principal stress in the northern part of Beichuan Fault (BFC) is rotated approximately counterclockwise compared to that in the southern part of BFC, yet this rotation is not sufficient to produce a supershear rupture. We infer that the fault core zone in the southwestern Beichuan Fault (BCF) may have been more severely damaged than the northeastern counterpart, which provides an explanation that the rupture in the northern BCF propagates faster than in the southern portion. Besides, we find that Coulomb failure stress changes on Wenchuan‐Maoxian Fault (WMF) may be counteracted by the aftershock slips of the Lixian Fault, which suggests Wenchuan earthquake could not significantly push the WMF closer to failure.
From bulk, single-cell to spatial RNA sequencing
Authors: Li Xinmin , Wang Cun-Yu 
Published: November 2021

AbstractRNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology.
G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript
Authors: Zheng Yinli , Wu Jinjun , Deng Ru , Lin Censhan , Huang Yuhua , Yang Xia , Wang Chunhua , Yang Mingming , He Yangfan , Lu Jiabin , Su Xiaodong , Yan Qian , Zhu Yinghui , Guan Xinyuan , Li Yan , Yun Jingping 
Published: November 2021

AbstractMetastasis is the leading cause of death of patients with esophageal squamous cell carcinoma (ESCC). Although an increasing number of studies have demonstrated the involvement of G3BP2 in several human cancers, how G3BP2 interacts with long noncoding RNAs and regulates mRNA transcripts in mediating ESCC metastasis remains unclear. In this study, we uncovered that G3BP2 was upregulated in ESCC. Further analysis revealed that upregulation of G3BP2 was significantly correlated with lymph node metastasis, depth of tumor invasion and unfavorable outcomes in ESCC patients. Both in vitro and in vivo functional assays demonstrated that G3BP2 dramatically enhanced ESCC cell migration and invasion. Mechanistically, LINC01554 maintained the high G3BP2 expression in ESCC by protecting G3BP2 from degradation through ubiquitination and the interaction domains within LINC01554 and G3BP2 were identified. In addition, RNA-seq revealed that HDGF was regulated by G3BP2. G3BP2 bound to HDGF mRNA transcript to stabilize its expression. Ectopic expression of HDGF effectively abolished the G3BP2 depletion-mediated inhibitory effect on tumor cell migration. Intriguingly, introduction of compound C108 which can inhibit G3BP2 remarkedly suppressed ESCC cell metastasis in vitro and in vivo. Collectively, this study describes a newly discovered regulatory axis, LINC01554/G3BP2/HDGF, that facilitates ESCC metastasis and will provide novel therapeutic strategies for ESCC.
BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β
Authors: Saha Akash , Saleem Suraiya , Paidi Ramesh Kumar , Biswas Subhas C. 
Published: November 2021

AbstractAlzheimer’s disease (AD) is characterized by accumulation of senile amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles causing progressive loss of synapse and neuronal death. Out of the various neuron death modalities, autophagy and apoptosis are reported to be the major death paradigms in AD. However, how these two processes lead to neuronal loss is still inconspicuous. Here we report that under Aβ toxicity, aberrant autophagy is induced with inefficient autophagic flux in neurons. Simultaneous activation of both autophagy and apoptosis are seen in primary cortical neurons as well as in transgenic mice brains. We found that induction of autophagy by rapamycin is detrimental for neurons; whereas downregulation of Beclin1, an important autophagy inducing protein, provides significant protection in Aβ treated neuronal cells by blocking cytochrome-c release from the mitochondria. We further report that downregulation of Puma, a BH3-only pro-apoptotic protein, inhibits the induction of aberrant autophagy and also ameliorates the autophagy flux under the influence of Aβ. Notably, stereotactic administration of shRNAs against Puma and Beclin1 in adult Aβ-infused rat brains inhibits both apoptotic and autophagic pathways. The regulation of both of the death processes is brought about by the direct interaction between Puma and Beclin1 upon Aβ treatment. We conclude that both Beclin1 and Puma play essential roles in the neuronal death caused by the induction of aberrant autophagy in AD and targeting their interaction could be vital to understand the crosstalk of autophagy and apoptosis as well as to develop a potential therapeutic strategy in AD.