bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low‐grade glioma
Authors: Hamimed Mourad , Gattacceca Florence , André Nicolas , Tresch‐Bruneel Emmanuelle , Probst Alicia , Chastagner Pascal , Pagnier Anne , De Carli Emilie , Entz‐Werlé Natacha , Grill Jacques , Aerts Isabelle , Frappaz Didier , Bertozzi‐Salamon Anne‐Isabelle , Solas Caroline , Leblond Pierre 
Published: October 2021

AimsThere is a crucial need for pharmacokinetic (PK) data on oral vinorelbine (VNR) in the paediatric population. The aim of this work was to assess the PK profile of orally administered VNR in children with recurrent/progressive primary low‐grade glioma (LGG).MethodsA multicentre, open‐label, single‐arm intervention phase II study was conducted. Patients, aged between 6 and 18 years, with histologically confirmed recurrent or progressive primary LGG or non‐documented typical optic pathway tumours, were included. PK parameters were estimated by non‐compartmental analysis using Phoenix WinNonlin® software (version 8.0, Certara, Inc.). The influence of demographic and biological covariates on VNR PK parameters was investigated using a multivariate linear regression analysis.ResultsPK analysis included 36 patients with a median age (range) of 11 (6–17) years. Estimates of apparent oral clearance (CL/F), apparent volume of distribution (V/F), half‐life (t1/2) and their between‐subject variability (CV%) at 60 mg m−2 dose level, were 472 L h−1 (51.8%), 7002 L (57.9%) and 10 h (21.0%), respectively. Negligible accumulation of VNR between C1 and C2 was observed. CL/F and V/F were found to increase with body surface area (BSA) (P = .004). Lower area under the concentration–time curve (AUC) levels were observed among children in comparison to adults.ConclusionHigher doses may be necessary for children with LGG. BSA showed a significant impact on VNR systemic exposure. We believe that our findings will serve as a basis for further studies to better characterize the concentration–response relationships of VNR among paediatric patients.
Corporate social responsibility and employee attitudes: The moderating role of employee age
Authors: Nyuur Richard B. , Ofori Daniel F. , Amankwah Majoreen O. , Baffoe Kwame Amin 
Published: October 2021

AbstractThis study examines the role of corporate social responsibility (CSR) on employee engagement and job satisfaction. Using 322 responses from employees of selected companies in Ghana, and employing hierarchical regression analysis, the study examines the direct impact of economic, legal, ethical and discretionary CSR practices on employee satisfaction and engagement in organisations. The study further explores the moderating role of employee age on the relationship between CSR and employee engagement and satisfaction. The results provide evidence that economic, legal, ethical and discretionary CSR practices influence higher employee engagement and satisfaction levels at work. However, the study finds no evidence of employee age moderating the association between each of the four CSR dimensions and employee job attitudes (engagement and satisfaction). These findings are insightful and provide a response to calls for research on these issues. The study contributes to the literature by demonstrating that ethical CSR practices strongly influence employees' satisfaction and engagement levels; legal and discretionary CSR activities also have an influence, though to a lesser extent; and the economic dimension of CSR activities has the least impact. The managerial, practical and further research implications of these findings are discussed.
Is alcohol use associated with psychological treatment attendance and clinical outcomes?
Authors: Hunt Vanessa J. , Delgadillo Jaime 
Published: October 2021

ObjectivesTo investigate associations between alcohol use, psychological treatment attendance, and clinical outcomes.MethodsWe analysed electronic health records for N = 7,986 patients accessing psychological treatment for common mental disorders. Data were collected for pre‐treatment alcohol use (average units per week) and severity of dependence (SDS), number of therapy contacts attended, pre‐ and post‐treatment anxiety (GAD‐7), and depression (PHQ‐9) symptom severity. Hierarchical regression was used to examine associations between alcohol use/dependence and post‐treatment symptom severity controlling for intake severity and relevant confounders.ResultsAfter controlling for confounders, alcohol use had significant nonlinear associations with pre‐treatment depression severity (R2 = .54, p < .01, cubic trend), and post‐treatment anxiety (R2 = .23, p < .01, quadratic trend). Alcohol use was not significantly associated with intake anxiety, post‐treatment depression or treatment duration. SDS was not significantly associated with depression severity, alcohol severity, or total contacts after controlling for confounders.ConclusionAlcohol users are just as likely to engage in and benefit from evidence‐based psychological treatments for depression in primary care. A nonlinear association between alcohol use and anxiety treatment outcomes indicates that light‐to‐moderate drinkers have some shared characteristic that favours treatment response.Practitioner points

Depression and anxiety problems often co‐occur with alcohol use and dependence.

Conventional wisdom in the field suggests that heavy alcohol users may not engage well or benefit from psychological therapies for depression and anxiety.

We found no empirical support for the above assumptions in a large clinical sample.

Alcohol consumption was not significantly associated with treatment attendance or depression treatment outcomes.

A nonlinear association between alcohol use and anxiety outcomes suggests that moderate drinkers may have some shared characteristic that favours treatment response.
Testing reward‐cue attentional salience: Attainment and dynamic changes
Authors: De Tommaso Matteo , Turatto Massimo 
Published: October 2021

AbstractA great wealth of studies has investigated the capacity of motivationally relevant stimuli to bias attention, suggesting that reward predicting cues are prioritized even when reward is no longer delivered and when attending to such stimuli is detrimental to reward achievement. Despite multiple procedures have been adopted to unveil the mechanisms whereby reward cues gain attentional salience, some open questions remain. Indeed, mechanisms different from motivation can be responsible for the capture of attention triggered by the reward cue. In addition, we note that at present only a few studies have sought to address whether the cue attractiveness dynamically follows changes in the associated reward value. Investigating how and to what extent the salience of the reward cue is updated when motivation changes, could help shedding light on how reward‐cues attain and maintain their capacity to attract attention, and therefore on apparent irrational attentive behaviors.
Do households with debt cut back their consumption more? New evidence from the United Kingdom
Authors: Fasianos Apostolos , Lydon Reamonn 
Published: October 2021

AbstractWe investigate whether the debt position of UK households affects the response of nondurable consumption to income and wealth changes. We construct a novel estimate of nondurable consumption to track the same individual households over time for an extended period ranging from 1993 to 2017. Using this series, we explore how household indebtedness propagates negative and positive income and wealth changes to consumption responses. We assess whether negative and positive shocks imply the same consumption adjustments and whether such mechanism is crisis specific. Our evidence reveals that falls in income trigger substantially larger adjustments in consumption than income rises for households with debt, while the findings for wealth are less conclusive. The results also point to a macro‐financial link between a debt overhang and consumer spending, which carries implications for macro‐prudential policy makers aiming to ensure household resilience. These effects are not specific to the financial crisis period.
Biallelic ZNFX1 variants are associated with a spectrum of immuno‐hematological abnormalities
Authors: Alawbathani Salem , Westenberger Ana , Ordonez‐Herrera Natalia , Al‐Hilali Mariam , Al Hebby Homoud , Alabbas Fahad , Alhashem Amal M. , Elyamany Ghaleb , Megarbane André , Kose Melis , Alhashmi Nadia , Al Sukaiti Nashat , Al‐Raqad Mohammed , Al‐Tawalbeh Samah , Abu Adas Blanco Omar , Alkhattabi Fadiah , Sng Danielle , Al‐Ali Ruslan , Khan Suliman , Tawamie Hasan , Tripolszki Kornelia , Karageorgou Vasiliki , Trunzo Roberta , Al Mutairi Fuad , Reversade Bruno , Bauer Peter , Bertoli‐Avella Aida M. 
Published: October 2021

AbstractBiallelic changes in the ZNFX1 gene have been recently reported to cause severe familial immunodeficiency. Through a search of our bio/databank with information from genetic testing of >55 000 individuals, we identified nine additional patients from seven families with six novel homozygous ZNFX1 variants. Consistent with the previously described phenotype, our patients suffered from monocytosis, thrombocytopenia, hepatosplenomegaly, recurrent infections, and lymphadenopathy. The two most severely affected probands also had renal involvement and clinical presentations compatible with hemophagocytic lymphohistiocytosis. The disease was less lethal among our patients than previously reported. We identified two missense changes, two variants predicted to result in complete protein loss through nonsense‐mediated decay, and two frameshift changes that likely introduce a truncation. Our findings (i) independently confirm the role of ZNFX1 in primary genetic immunodeficiency, (ii) expand the genetic and clinical spectrum of ZNFX1‐related disease, and (iii) illustrate the utility of large, well‐curated, and continually updated genotype–phenotype databases in resolving molecular diagnoses of patients with initially negative genetic testing findings.
The significance of subdivisions of microscopically positive (R1) margins in colorectal cancer: A retrospective study of a national cancer registry
Authors: Smith Henry G. , Chiranth Deepthi , Mortensen Christiane E. , Schlesinger Nis H. 
Published: October 2021

AbstractAimMicroscopically positive (R1) margins are associated with poorer outcomes in patients with colorectal cancer. However, little is known of the differential impact of subdivisions of R1 margins, be they to the primary tumour (R1tumour) or to lymph node metastases/tumour deposits (R1LNM).MethodsPatients treated for Stage III colorectal cancer from 1 January 2016 to 31 December 2019 were identified from the Danish national cancer registry. Patients were stratified into three groups according to margin status (R0 vs. R1tumour vs. R1LNM). The primary outcome was overall survival.ResultsIn all, 4186 patients were included, comprising 3012 patients with colon cancer and 1174 patients with rectal cancer. The R1 resection rates were 16.5% and 18.2% in patients with colon and rectum cancer, respectively. In colon cancers, 3‐year overall survival was reduced in patients with R1LNM (65.7%, 95% CI 62.8–68.6) or R1tumour margins (51.8%, 95% CI 47.3–56.3) compared with R0 resections (80.8%, 95% CI 79.9–81.6, P < 0.001). A similar impact on survival was seen in rectal cancers (R0, 84.2%, 95% CI 82.9–85.5; R1LNM, 72.2%, 95% CI 67.8–76.6; R1tumour, 56.6%, 95% CI 50.0–63.2, P < 0.001). Margin status was independently prognostic of survival in both colon (R1tumour, hazard ratio 2.08, 95% CI 1.50–2.89, P < 0.001; R1LNM, hazard ratio 1.48, 95% CI 1.11–1.97, P = 0.008) and rectal cancers (R1tumour, hazard ratio 2.35, 95% CI 1.42–3.90, P < 0.001; R1LNM, hazard ratio 1.54, 95% CI 0.95–2.48, P = 0.077).ConclusionR1 subdivisions have distinct impacts on survival in Stage III colorectal cancer. Further focused research in these patient subgroups is warranted.
Measurement of Science Museum Visitors’ Emotional Experiences at Exhibits Designed to Encourage Productive Struggle
Authors: May Sarah , Todd Katie , Daley Samantha G. , Rappolt‐Schlichtmann Gabrielle 
Published: October 2021

AbstractThis study measured science museum visitors’ emotional experiences at exhibits designed to encourage productive struggle (PS), an emotional experience where visitors productively persist through challenge. The study included 105 youth visitors ages 10–17 who interacted with one of three science exhibits designed to promote PS. Emotion was measured using a convergent mixed‐methods design, including self‐report ratings of the extent to which 13 emotions were experienced, coupled with narrative data generated through guided recall activities. Results indicated that most visitors experienced the constellation of emotions characteristic of PS, and that experiences of PS took on varied forms. These findings validated and enriched the emotional components expected to comprise PS, and suggested that the construct of PS can meaningfully characterize patterns of effortful engagement. Attending to visitors’ emotional meaning‐making, particularly through the productive resolution of challenge, can inform the purposeful design of exhibits that harness emotions to deepen visitor learning and engagement.
Curating the Contemporary: A Case for National and Local COVID‐19 Collections
Authors: Spennemann Dirk H.R. 
Published: October 2021

AbstractWith its rapid spread, intensity, duration, global geographic reach and cross‐sectorial disruption, the impact of the COVID‐19 pandemic is so profound that it will become the focus of public exhibitions in the future.Nowis the time is to collect examples of material culture associated with COVID‐19. Some of the material is generic to healthcare, but some is specific to responses to COVID‐19 in the medical and community sphere (e.g. social distancing). A substantive number of objects only exist in the digital sphere. Expanding on concepts initially developed for the collection of items associated with natural disasters and terrorist events, this paper (i) outlines the need for the establishment of local and national collections before items become too scarce and (ii) provides a sample multi‐phase collections and collections management framework.
Cannabinoids interaction with transient receptor potential family and implications in the treatment of rosacea
Authors: Garbutcheon‐Singh Kieran B. , Smith Saxon D. 
Published: October 2021

AbstractWith the recent interest in medical marijuana, research into cannabinoids is regaining wider attention. Cannabinoids are collectively a group of active compounds that can be produced by animals (endocannabinoids), plants (phytocannabinoids), or synthetically. By acting on a number of different receptors like cannabinoids receptors and transient receptor potential ion channel family, cannabinoids are known to modulate cutaneous inflammation, pain, and itch. Rosacea is a highly prevalent disease and can be associated with a significant degree of morbidity associated with its symptom. Transient receptor potential ion channels are known to be triggered in rosacea and may underlie a portion of rosacea's pathophysiology. This article aims to detail the transient receptor potential channel pathways in rosacea and the known effects of cannabinoids on these pathways and further discussing the potential role of cannabinoids in treating rosacea.
Shrub expansion modulates belowground impacts of changing snow conditions in alpine grasslands
Authors: Broadbent Arthur A. D. , Bahn Michael , Pritchard William J. , Newbold Lindsay K. , Goodall Tim , Guinta Andrew , Snell Helen S. K. , Cordero Irene , Michas Antonios , Grant Helen K. , Soto David X. , Kaufmann Rüdiger , Schloter Michael , Griffiths Robert I. , Bardgett Richard D. 
Published: October 2021

AbstractClimate change is disproportionately impacting mountain ecosystems, leading to large reductions in winter snow cover, earlier spring snowmelt and widespread shrub expansion into alpine grasslands. Yet, the combined effects of shrub expansion and changing snow conditions on abiotic and biotic soil properties remains poorly understood. We used complementary field experiments to show that reduced snow cover and earlier snowmelt have effects on soil microbial communities and functioning that persist into summer. However, ericaceous shrub expansion modulates a number of these impacts and has stronger belowground effects than changing snow conditions. Ericaceous shrub expansion did not alter snow depth or snowmelt timing but did increase the abundance of ericoid mycorrhizal fungi and oligotrophic bacteria, which was linked to decreased soil respiration and nitrogen availability. Our findings suggest that changing winter snow conditions have cross‐seasonal impacts on soil properties, but shifts in vegetation can modulate belowground effects of future alpine climate change.
Protective effects of medium chain triglyceride diet in a mouse model of Dravet syndrome
Authors: Jancovski Nikola , Baldwin Tomas , Orford Michael , Li Melody , Jones Gabriel Davis , Burbano Lisseth Estefania , Rutherford Tricia , Reid Christopher , Heales Simon , Eaton Simon , Petrou Steven 
Published: October 2021

AbstractObjectiveDravet syndrome (DS) is a severe developmental and epileptic encephalopathy with early childhood onset. Patients with DS do not respond well to antiepileptic drugs and have only a few treatment options available. Here, we evaluated the effect of medium chain triglyceride (MCT) diet therapy in a mouse model of DS.MethodsScn1aR1407X/+ DS mice were given diets supplemented with MCTs with varying ratios of decanoic (C10) and octanoic (C8) acid or a control diet for 4 weeks. Video monitoring was performed to evaluate spontaneous convulsive seizure frequency. Susceptibility to hyperthermia‐induced seizures was also examined. Medium chain fatty acids, and mitochondrial and antioxidant markers were assessed in brain homogenate.ResultsDietary intervention with MCTs significantly prolonged survival and reduced convulsive seizure frequency during the critical period of highest seizure occurrence in the Scn1aR1407X/+ DS mice. Moreover, MCT diet therapy showed protective effects against hyperthermia‐induced seizures. We demonstrated that coadministration of C10/C8 was effective at reducing both seizures and mortality, whereas C10 alone only reduced mortality, suggesting that the ratio of C10 to C8 in the MCT is an important factor for efficacy. When C10 and C8 are supplemented at an 80:20 ratio in the diet, C10 accumulates in the brain in high enough concentrations to enhance brain energy metabolism by both stimulating mitochondrial enrichment and increasing its antioxidant status.SignificanceThe results from this study indicate that MCT diet therapy may provide therapeutic benefits in DS. Future clinical studies would elucidate whether these positive effects are mirrored in human patients.
Artificial intelligence as a tool to aid in the differentiation of equine ophthalmic diseases with an emphasis on equine uveitis
Authors: May Anna , Gesell‐May Stefan , Müller Tobias , Ertel Wolfgang 
Published: October 2021

SummaryBackgroundDue to recent developments in artificial intelligence, deep learning, and smart‐device‐technology, diagnostic software may be developed which can be executed offline as an app on smartphones using their high‐resolution cameras and increasing processing power to directly analyse photos taken on the device.ObjectivesA software tool was developed to aid in the diagnosis of equine ophthalmic diseases, especially uveitis.Study designProspective comparison of software and clinical diagnoses.MethodsA deep learning approach for image classification was used to train software by analysing photographs of equine eyes to make a statement on whether the horse was displaying signs of uveitis or other ophthalmic diseases. Four basis networks of different sizes (MobileNetV2, InceptionV3, VGG16, VGG19) with modified top‐layers were evaluated. Convolutional Neural Networks (CNN) were trained on 2346 pictures of equine eyes, which were augmented to 9384 images. 261 separate unmodified images were used to evaluate the performance of the trained network.ResultsCross validation showed accuracy of 99.82% on training data and 96.66% on validation data when distinguishing between three categories (uveitis, other ophthalmic diseases, healthy).Main limitationsOne source of selection bias for the artificial intelligence presumably was the increased pupil size, which was mainly present in horses with ophthalmic diseases due to the use of mydriatics, and was not homogeneously dispersed in all categories of the dataset.ConclusionsOur system for detection of equine uveitis is unique and novel and can differentiate between uveitis and other equine ophthalmic diseases. Its development also serves as a proof‐of‐concept for image‐based detection of ophthalmic diseases in general and as a basis for its further use and expansion.
Climate change concerns meet return‐chasing: Evidence from energy exchange‐traded funds
Authors: Lantushenko Viktoriya , Schellhorn Carolin , Zaynutdinova Gulnara R. 
Published: October 2021

AbstractDecarbonizing the global economy is a challenge requiring massive funding and coordination across all economic sectors. Energy ETFs play an important role in this transition. We find that investment flows into alternative energy ETFs (A‐ETFs) increase with climate change risk. After the Paris Agreement, A‐ETFs experience significantly stronger net flows than traditional energy ETFs (T‐ETFs): A one‐standard‐deviation increase in fund return results in about 8–12% higher net flows per year to A‐ETFs compared with T‐ETFs. Return‐sensitive investors appear to have joined the early climate‐concerned investors after the global investment community made public its determination to take climate action post 2015.
The COVID‐19 pandemic: Narratives of informal women workers in Indian Punjab
Authors: Singh Nadia , Kaur Areet 
Published: October 2021

AbstractThe COVID‐19 crisis has translated into an unprecedented humanitarian crisis for the poor and marginalized groups in society. The countrywide lockdowns, quarantine measures, and mobility restrictions across 200 countries of the world have resulted in a host of negative manifestations for women. There have been unprecedented losses in the informal economy, which is dominated by women. Some scholars also contend that the pandemic will translate into heightened burden of unpaid domestic work, loss of economic autonomy and disruption to maternal health services. Despite these factors a gendered perspective is absent in the policy response to this crisis. It is against this background that the present paper employed a feminist intersectionality lens to conduct participatory field based research on the lived experiences of women in informal employment in Indian Punjab during the COVID‐19 crisis. The research unearthed the specific pathways through which existing socio‐economic inequities rooted in caste, class and occupational entities magnify the vulnerabilities experienced by women during such a health crisis. The research offers a contextualized framework for understanding the gendered impacts of the crisis. It also highlights the urgency of taking account of gender specific constraints during the health crisis so as to institute robust, effective and equitable policy interventions.