bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors, time course, and outcomes of persistence patterns in oral anticoagulation for non-valvular atrial fibrillation: a Dutch Nationwide Cohort Study
Authors: Toorop Myrthe M A , Chen Qingui , Tichelaar Vladimir Y I G , Cannegieter Suzanne C , Lijfering Willem M 
Published: June 2021

Abstract

Aims
Persistence with direct oral anticoagulants (DOACs) has become a concern in non-valvular atrial fibrillation (NVAF) patients, but whether this affects prognosis is rarely studied. We investigated the persistence with oral anticoagulants (OACs) and its association with prognosis among a nationwide cohort of NVAF patients.

Methods and results
DOAC-naive NVAF patients who started to use DOACs for ischaemic stroke prevention between 2013 and 2018 were included using Dutch national statistics. Persistence with OACs was determined based on the presence of a 100-day gap between the last prescription and the end of study period. In 93 048 patients, 75.7% had a baseline CHA2DS2-VASc score of ≥2. The cumulative incidence of persistence with OACs was 88.1% [95% confidence interval (CI) 87.9–88.3%], 82.6% (95% CI 82.3–82.9%), 77.7% (95% CI 77.3–78.1%), and 72.0% (95% CI 71.5–72.5%) at 1, 2, 3, and 4 years after receiving DOACs, respectively. Baseline characteristics associated with better persistence with OACs included female sex, age range 65–74 years, permanent atrial fibrillation, previous exposure to vitamin K antagonists, stroke history (including transient ischaemic attack), and a CHA2DS2-VASc score ≥2. Non-persistence with OACs was associated with an increased risk of the composite outcome of ischaemic stroke and ischaemic stroke-related death [adjusted hazard ratio (aHR) 1.79, 95% CI 1.49–2.15] and ischaemic stroke (aHR 1.58, 95% CI 1.29–1.93) compared with being persistent with OACs.

Conclusion
At least a quarter of NVAF patients were non-persistent with OACs within 4 years, which was associated with poor efficacy of ischaemic stroke prevention. The identified baseline characteristics may help identify patients at risk of non-persistence.
Combining home monitoring temporal trends from implanted defibrillators and baseline patient risk profile to predict heart failure hospitalizations: results from the SELENE HF study
Authors: D’Onofrio Antonio , Solimene Francesco , Calò Leonardo , Calvi Valeria , Viscusi Miguel , Melissano Donato , Russo Vitantonio , Rapacciuolo Antonio , Campana Andrea , Caravati Fabrizio , Bonfanti Paolo , Zanotto Gabriele , Gronda Edoardo , Vado Antonello , Calzolari Vittorio , Botto Giovanni Luca , Zecchin Massimo , Bontempi Luca , Giacopelli Daniele , Gargaro Alessio , Padeletti Luigi 
Published: June 2021

Abstract

Aims
We developed and validated an algorithm for prediction of heart failure (HF) hospitalizations using remote monitoring (RM) data transmitted by implanted defibrillators.

Methods and results
The SELENE HF study enrolled 918 patients (median age 69 years, 81% men, median ejection fraction 30%) with cardiac resynchronization therapy (44%), dual-chamber (38%), or single-chamber defibrillators with atrial diagnostics (18%). To develop a predictive algorithm, temporal trends of diurnal and nocturnal heart rates, ventricular extrasystoles, atrial tachyarrhythmia burden, heart rate variability, physical activity, and thoracic impedance obtained by daily automatic RM were combined with a baseline risk-stratifier (Seattle HF Model) into one index. The primary endpoint was the first post-implant adjudicated HF hospitalization. After a median follow-up of 22.5 months since enrolment, patients were randomly allocated to the algorithm derivation group (n = 457; 31 endpoints) or algorithm validation group (n = 461; 29 endpoints). In the derivation group, the index showed a C-statistics of 0.89 [95% confidence interval (CI): 0.83–0.95] with 2.73 odds ratio (CI 1.98–3.78) for first HF hospitalization per unitary increase of index value (P &lt; 0.001). In the validation group, sensitivity of predicting primary endpoint was 65.5% (CI 45.7–82.1%), median alerting time 42 days (interquartile range 21–89), and false (or unexplained) alert rate 0.69 (CI 0.64–0.74) [or 0.63 (CI 0.58–0.68)] per patient-year. Without the baseline risk-stratifier, the sensitivity remained 65.5% and the false/unexplained alert rates increased by ≈10% to 0.76/0.71 per patient-year.

Conclusion
With the developed algorithm, two-thirds of first post-implant HF hospitalizations could be predicted timely with only 0.7 false alerts per patient-year.
Specific content for collaborative care: a systematic review of collaborative care interventions for patients with multimorbidity involving depression and/or anxiety in primary care
Authors: Kappelin Caroline , Carlsson Axel C , Wachtler Caroline 
Published: June 2021

Abstract

Background
In primary care (PC) many patients suffer from multimorbidity involving depression and/or anxiety. Collaborative care (CC) has shown promising results for patients with depression, anxiety, and multimorbidity involving depression. However, specific content in CC for patients with multimorbidity involving depression and/or anxiety is unknown.

Objective
(i) To examine the effect of CC interventions in patients with multimorbidity involving depression and/or anxiety compared with usual care; (ii) to identify specific content of CC.

Methods
We conducted a systematic literature review of randomized controlled trial studies evaluating CC models for adults with multimorbidity involving depression and/or anxiety in PC settings. PubMed, CINAHL, Web of Science, and PsycInfo were searched in December 2019. We conducted a qualitative synthesis using an existing framework and developed a new framework to map the content for each studied intervention.

Results
We identified 1,447 studies. Twelve publications were included. Eleven had medium-to-high quality of CC for patients with multimorbidity involving depression. Specific content of CC in these studies is: A stepped care model, involving medication and psychotherapy delivered by a nurse or psychologist Care Manager (CM) focusing on problem-solving techniques; follow-up including monitoring of symptoms and function, and relapse prevention strategies; scheduled CM supervision.

Conclusions
Specific content for CC for patients with multimorbidity involving depression is identified from current research. Research gaps were found regarding CC for patients with multimorbidity and anxiety, depression and anxiety, and depression and/or anxiety and more than 2 diseases.
Genetic andin uteroenvironmental contributions to DNA methylation variation in placenta
Authors: Chatterjee Suvo , Ouidir Marion , Tekola-Ayele Fasil 
Published: June 2021

AbstractGenetic and prenatal environmental factors shape fetal development and cardiometabolic health in later life. A key target of genetic and prenatal environmental factors is the epigenome of the placenta, an organ that is implicated in fetal growth and diseases in later life. This study had two aims: (1) to identify and functionally characterize placental variably methylated regions (VMRs), which are regions in the epigenome with high inter-individual methylation variability; and (2) to investigate the contributions of fetal genetic loci and 12 prenatal environmental factors (maternal cardiometabolic-,psychosocial-, demographic- and obstetric-related) on methylation at each VMR. Akaike’s information criterion was used to select the best model out of four models [prenatal environment only, genotype only, additive effect of genotype and prenatal environment (G + E), and their interaction effect (G × E)]. We identified 5850 VMRs in placenta. Methylation at 70% of VMRs was best explained by G × E, followed by genotype only (17.7%), and G + E (12.3%). Prenatal environment alone best explained only 0.03% of VMRs. We observed that 95.4% of G × E models and 93.9% of G + E models included maternal age, parity, delivery mode, maternal depression or gestational weight gain. VMR methylation sites and their regulatory genetic variants were enriched (P &lt; 0.05) for genomic regions that have known links with regulatory functions and complex traits. This study provided a genome-wide catalog of VMRs in placenta and highlighted that variation in placental DNA methylation at loci with regulatory and trait relevance is best elucidated by integrating genetic and prenatal environmental factors, and rarely by environmental factors alone.
Outcomes for Hand Burns Treated With Autologous Skin Cell Suspension in 20% TBSA and Smaller Injuries
Authors: Taylor George Malcolm , Barnett Scott A , Tuggle Charles T , Carter Jeff E , Phelan Herb A 
Published: June 2021

Abstract
In order to address the confounder of TBSA on burn outcomes, we sought to analyze our experience with the use of autologous skin cell suspensions (ASCS) in a cohort of subjects with hand burns whose TBSA totaled 20% or less. We hypothesized that the use of ASCS in conjunction with 2:1 meshed autograft for the treatment of hand burn injuries would provide comparable outcomes to hand burns treated with sheet or minimally meshed autograft alone. A retrospective review was conducted for all deep partial and full-thickness hand burns treated with split-thickness autograft (STAG) at our urban verified burn center between April 2018 and September 2020. The exclusion criterion was a TBSA greater than 20%. The cohorts were those subjects treated with ASCS in combination with STAG (ASCS(+)) vs those treated with STAG alone (ASCS(−)). All ASCS(+) subjects were treated with 2:1 meshed STAG and ASCS overspray while all ASCS(−) subjects had 1:1, piecrust, or unmeshed sheet graft alone. Outcomes measured included demographics, time to wound closure, proportion returning to work (RTW), and length of time to RTW. Mann–Whitney U test was used for comparisons of continuous variables and Fisher’s exact test for categorical variables. Values are reported as medians and 25th and 75th interquartile ranges. Fifty-one subjects fit the study criteria (ASCS(+) n = 31, ASCS(−) n = 20). The ASCS(+) group was significantly older than the ASCS(−) cohort (44 [32–54] vs 32 years [27.5–37], P = .009) with larger %TBSA burns (15% [9.5–17] vs 2% [1–4], P &lt; .0001) and larger size hand burns (190 [120–349.5] vs 126 cm2 [73.5–182], P = .015). Comparable results were seen between ASCS(+) and ASCS(−), respectively, for time to wound closure (9 [7–13] vs 11.5 days [6.75–14], P = .63), proportion RTW (61% vs 70%, P = .56), and days for RTW among those returning (35 [28.5–57] vs 33 [20.25–59], P = .52). The ASCS(+) group had two graft infections with no reoperations, while ASCS(−) had one infection with one reoperation. No subjects in either group had a dermal substitute placed. Despite being significantly older, having larger hand wounds, and larger overall wounds within the parameters of the study criteria, patients with 20% TBSA burns or smaller whose hand burns were treated with 2:1 mesh and ASCS overspray had comparable time to wound closure, proportion of RTW, and time to return to work as subjects treated with 1:1 or piecrust meshed STAG. Our group plans to follow this work with scar assessments for a more granular picture of pliability and reconstructive needs.
Temperature drives spatial and temporal variation in the reproductive biology of the blue swimmer crab Portunus armatus A. Milne-Edwards, 1861 (Decapoda: Brachyura: Portunidae)
Authors: Johnston Danielle J , Yeoh Daniel E 
Published: June 2021

Abstract
Sound fisheries management requires knowledge of how the reproductive biology of targeted species varies over space and time and responds to external drivers. We determined the size at maturity and fecundity of the blue swimmer crab Portunus armatus (A. Milne-Edwards, 1861) (Brachyura: Portunidae) along the west coast of Australia at monthly, annual and interdecadal (1990s versus 2010s) time scales. The size at maturity of females determined by abdominal morphology (carapace width (CW) at 50% maturity (CW50)) was highest in sub-tropical Shark Bay at 26°S (104 mm), and declined latitudinally to temperate Geographe Bay at 34°S (93 mm). A notable exception was in a marine embayment at 32°S (Cockburn Sound), where CW50 was significantly lower than all other locations (83 mm). In contrast, batch fecundity was lower in sub-tropical (830,000 eggs at 127 mm CW) than temperate waters (950,000–990,000 eggs). Temporally, CW50 was significantly higher during January-June (typical growth period, encompassing the warmest months of the year) than during July-December (breeding period), and also differed between months, years, and decades. Positive correlations between water temperature, monthly and annual estimates of CW50, and functional maturity (size at first ovigery), were detected in most locations. Annual CW50 also increased with population density, particularly in locations where abundances and biomass were lowest. Results highlight plasticity in the reproductive biology of this portunid in response to environmental drivers such as temperature. Regular review of such parameters is important for ensuring robust fisheries management and stock assessments.
Determinants of migration trajectory and movement rate in a long-distance terrestrial mammal
Authors: Leclerc Martin , Leblond Mathieu , Le Corre Maël , Dussault Christian , Côté Steeve D 
Published: June 2021

Abstract
Animal migrations occur in many taxa and are considered an adaptive response to spatial or temporal variations in resources. Human activities can influence the cost-benefit trade-offs of animal migrations, but evaluating the determinants of migration trajectory and movement rate in declining populations facing relatively low levels of human disturbance can provide new and valuable insights on the behavior of wildlife in natural environments. Here, we used an adapted version of path selection functions and quantified the effects of habitat type, topography, and weather, on 313 spring migrations by migratory caribou (Rangifer tarandus) in northern Québec, Canada, from 2011 to 2018. Our results showed that during spring migration, caribou selected tundra and avoided water bodies, forest, and higher elevation. Higher precipitation and deeper snow were linked to lower movement rates. Weather variables had a stronger effect on the migration trajectories and movement rates of females than males. Duration of caribou spring migration (mean of 48 days) and length (mean of 587 km) were similar in males and females, but females started (22 April) and ended (10 June) spring migrations ca. 6 days earlier than males. Caribou spring migration was influenced by habitat type, topography, and weather, but we also observed that caribou migrations were not spatially constrained. Better knowledge on where and when animals move between their winter and summer ranges can help inform management and land planning decisions. Our results could be used to model future migration trajectories and speed of caribou under different climate change scenarios.
The halo mass function and inner structure of ETHOS haloes at high redshift
Authors: Bohr Sebastian , Zavala Jesús , Cyr-Racine Francis-Yan , Vogelsberger Mark 
Published: June 2021

ABSTRACT
We study the halo mass function and inner halo structure at high redshifts (z ≥ 5) for a suite of simulations within the structure formation ETHOS framework. Scenarios such as cold dark matter (CDM), thermal warm dark matter (WDM), and dark acoustic oscillations (DAOs) of various strengths are contained in ETHOS with just two parameters hpeak and kpeak, the amplitude and scale of the first DAO peak. The extended Press–Schechter (EPS) formalism with a smooth-k filter is able to predict the cut-off in the halo mass function created by the suppression of small-scale power in ETHOS models (controlled by kpeak), as well as the slope at small masses that is dependent on hpeak. Interestingly, we find that DAOs introduce a localized feature in the mass distribution of haloes, resulting in a mass function that is distinct in shape compared to either CDM or WDM. We find that the halo density profiles of all ETHOS models are well described by the NFW profile, with a concentration that is lower than in the CDM case in a way that is regulated by kpeak. We show that the concentration–mass relation for DAO models can be well approximated by the mass assembly model based on the EPS theory, which has been proposed for CDM and WDM elsewhere. Our results can be used to perform inexpensive calculations of the halo mass function and concentration–mass relation within the ETHOS parametrization without the need of N-body simulations.
SN 2020cpg: an energetic link between Type IIb and Ib supernovae
Authors: Medler K , Mazzali P A , Teffs J , Prentice S J , Ashall C , Amenouche M , Anderson J P , Burke J , Chen T W , Galbany L , Gromadzki M , Gutiérrez C P , Hiramatsu D , Howell D A , Inserra C , Kankare E , McCully C , Müller-Bravo T E , Nicholl M , Pellegrino C , Sollerman J 
Published: June 2021

ABSTRACT
Stripped-envelope supernovae (SE-SNe) show a wide variety of photometric and spectroscopic properties. This is due to the different potential formation channels and the stripping mechanism that allows for a large diversity within the progenitors outer envelope compositions. Here, the photometric and spectroscopic observations of SN 2020cpg covering ∼130 d from the explosion date are presented. SN 2020cpg (z = 0.037) is a bright SE-SNe with the B-band peaking at MB = −17.75 ± 0.39 mag and a maximum pseudo-bolometric luminosity of Lmax = 6.03 ± 0.01 × 1042 erg s−1. Spectroscopically, SN 2020cpg displays a weak high- and low-velocity H α feature during the photospheric phase of its evolution, suggesting that it contained a detached hydrogen envelope prior to explosion. From comparisons with spectral models, the mass of hydrogen within the outer envelope was constrained to be ∼0.1 M⊙. From the pseudo-bolometric light curve of SN 2020cpg a 56Ni mass of MNi ∼ 0.27 ± 0.08 M⊙ was determined using an Arnett-like model. The ejecta mass and kinetic energy of SN 2020cpg were determined using an alternative method that compares the light curve of SN 2020cpg and several modelled SE-SNe, resulting in an ejecta mass of Mejc ∼ 5.5 ± 2.0 M⊙ and a kinetic energy of EK ∼ 9.0 ± 3.0 × 1051 erg. The ejected mass indicates a progenitor mass of 18−25 M⊙. The use of the comparative light curve method provides an alternative process to the commonly used Arnett-like model to determine the physical properties of SE-SNe.
Structure formation in large-volume cosmological simulations of fuzzy dark matter: impact of the non-linear dynamics
Authors: May Simon , Springel Volker 
Published: June 2021

ABSTRACT
An ultralight bosonic particle of mass around $10^{-22}\, \mathrm{eV}/c^2$ is of special interest as a dark matter candidate, as it both has particle physics motivations, and may give rise to notable differences in the structures on highly non-linear scales due to the manifestation of quantum-physical wave effects on macroscopic scales, which could address a number of contentious small-scale tensions in the standard cosmological model, ΛCDM. Using a spectral technique, we here discuss simulations of such fuzzy dark matter (FDM), including the full non-linear wave dynamics, with a comparatively large dynamic range and for larger box sizes than considered previously. While the impact of suppressed small-scale power in the initial conditions associated with FDM has been studied before, the characteristic FDM dynamics are often neglected; in our simulations, we instead show the impact of the full non-linear dynamics on physical observables. We focus on the evolution of the matter power spectrum, give first results for the FDM halo mass function directly based on full FDM simulations, and discuss the computational challenges associated with the FDM equations. FDM shows a pronounced suppression of power on small scales relative to cold dark matter (CDM), which can be understood as a damping effect due to ‘quantum pressure’. In certain regimes, however, the FDM power can exceed that of CDM, which may be interpreted as a reflection of order-unity density fluctuations occurring in FDM. In the halo mass function, FDM shows a significant abundance reduction below a characteristic mass scale only. This could in principle alleviate the need to invoke very strong feedback processes in small galaxies to reconcile ΛCDM with the observed galaxy luminosity function, but detailed studies that also include baryons will be needed to ultimately judge the viability of FDM.
Gas clumping in the outskirts of the Virgo cluster
Authors: Mirakhor M S , Walker S A 
Published: June 2021

ABSTRACT
Observations of the intracluster medium (ICM) in the outskirts of the Virgo cluster with Suzaku have found the gas mass fraction in the northern direction to be significantly above the expected level, indicating that there may be a very high level of gas clumping on small scales in this direction. Here we explore the XMM–Newton data in the outskirts of Virgo, dividing it into a Voronoi tessellation to separate the bulk ICM component from the clumped ICM component. As the nearest galaxy cluster, Virgo’s large angular extent allows the spatial scale of the tessellation to be much smaller than has been achieved using the same technique on intermediate-redshift clusters, allowing us to probe gas clumping on the scales down to 5 × 5 kpc2. We find that the level of gas clumping in the outskirts to the north is relatively mild, ($\sqrt{C} \lt 1.1$), suggesting that our point-source detection procedure may have excluded a significant fraction of clumps. While correcting for clumping brings the gas mass fraction at r200 into agreement with the universal gas mass fraction, the values outside r200 remain significantly above it. This may suggest that non-thermal pressure support in the outskirts to the north is significant, and we find that a non-thermal pressure support at the level of 20 per cent of the total pressure outside r200 can explain the high gas mass fraction to the north, which is in agreement with the range expected from simulations.
Characterization of the gene family encoding metal tolerance proteins in Triticum urartu: Phylogenetic, transcriptional, and functional analyses
Authors: Wang Fan-Hong , Qiao Kun , Shen Yong-Hua , Wang Hong , Chai Tuan-Yao 
Published: June 2021

Abstract
Homeostasis of microelements in organisms is vital for normal metabolism. In plants, the cation diffusion facilitator (CDF) protein family, also known as metal tolerance proteins (MTPs), play critical roles in maintaining trace metal homeostasis. However, little is known about these proteins in wheat. In this study, we characterized the MTP family of Triticum urartu, the donor of ‘A’ genome of Triticum aestivum, and analysed their phylogenetic relationships, sequence signatures, spatial expression patterns in the diploid wheat, and their transport activity when heterologously expressed. Nine MTPs were identified in the T. urartu genome database, and were classified and designated based on their sequence similarity to Arabidopsis thaliana (Arabidopsis) and Oryza sativa MTPs. Phylogenetic and sequence analyses indicated that the triticum urartu metal tolerance protein (TuMTP)s comprise three Zn-CDFs, two Fe/Zn-CDFs, and four Mn-CDFs; and can be further classified into six subgroups. Among the TuMTPs, there are no MTP2-5 and MTP9-10 counterparts but two MTP1/8/11 orthologs in relation to AtMTPs. It was also shown that members of the same cluster share similar sequence characteristic, i.e. number of introns, predicted transmembrane domains, and motifs. When expressed in yeast, TuMTP1 and TuMTP1.1 conferred tolerance to Zn and Co but not to other metal ions; while TuMTP8, TuMTP8.1, TuMTP11, and TuMTP11.1 conferred tolerance to Mn. When expressed in Arabidopsis, TuMTP1 localized to the tonoplast and significantly enhanced Zn and Co tolerance. TuMTPs showed diverse tissue-specific expression patterns. Taken together, the closely clustered TuMTPs share structural features and metal specificity but play diverse roles in the homeostasis of microelements in plant cells.