bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGANGKATAN ANAK DALAM PRESPEKTIF HUKUM ISLAM
Authors: Nurdiana Hera 
Published: September 2021

Konsep pengangkatan anak dalam hukum Islam tidak mengenal pengangkatan anak dalam arti menjadi anak kandung secara mutlak, sedang yang ada hanya diperbolehkan atau suruhan untuk memelihara dengan tujuan memperlakukan anak dalam segi kecintaan pemberian “nafkah“, pendidikan atau pelayanan dalam segala kebutuhan yang bukan memperlakukan sebagai anak kandung (nasab).Kata kunci: anak, pengangkatan, hukum Islam The concept of adoption in Islamic law does not recognize the adoption of a child in the sense of being an absolute biological child, and that there is only permissible or guardianship for the purpose of treating the child in terms of the love of the provision of "income", education or service in any need not treated as a child bladder (nasab).Keywords: child, rapture, Islamic law
THE EFFECT OF ROLE PLAYING AND SNOWBALL THROWING LEARNING MODEL ON STUDENTS’ SPEAKING SKILL AT GRADE III ELEMENTARY SCHOOL IN GUGUS RA KARTINI
Authors: Yusmi Yusmi , Su‘ad Su‘ad , Murtono Murtono 
Published: September 2021

The purpose of this study was to describe the influence of role playing and snowball throwing learning models on students’ speaking skills at third grade elementary school in RA Kartini cluster. This research was an experimental research. The population in this study were students at grade III of elementary schools in RA Kartini cluster. From this population, the research samples were 60 grade III elementary school students. Data collection techniques included giving questionnaires, observation and documentation. The final analysis utilized descriptive analysis and inferential analysis. Inferential analysis was coducted by operating independent sample t-test to determine the influence role playing and snowball throwing models. The results of the analysis of the first hypothesis test between the role playing class and the conventional class showed a significance value of 0,000 (0,000 <0.05) and the tcount value was 3,943, while the ttable value was 2.024 (3,943> 2,024), meaning that Ha1 was accepted. This indicated that role paying had an effect on speaking skills. The second hypothesis test between the snowball throwing class and the conventional class showed a significance value of 0.02 (0.02 <0.05) and the t-count value of 3.370, while the t-table value was 2.024 (3,370> 2,024) meaning that Ha2 was accepted. This confirmed that the snowball model throwing significantly influenced the students’ speaking skills. The third hypothesis test showed that between the role playing and snowball throwing learning models the significance value of speaking skills was 0.017 (0.017 < 0.05) and the t-count value was 2.498 while the t-table value was 2.024 (2.498> 2.024). Referring to the hypothesis testing, Ha was accepted and Ho3 was rejected while Ha3 was accepted. Thus, it was concluded that role playing learning model was more influential than snowball throwing learning on the students’ speaking skills at the second grade of elementary school in Gugus RA Kartini.
Promising Thermoelectric Performance in Two-Dimensional Semiconducting Boron Monolayer
Authors: Hu Yonglan , Li Ding , Liu Rongkun , Li Shichang , Feng Chunbao , Li Dengfeng , Ding Guangqian 
Published: September 2021

A heavy element is a special character for high thermoelectric performance since it generally guarantees a low lattice thermal conductivity. Here, we unexpectedly found a promising thermoelectric performance in a two-dimensional semiconducting monolayer consisting of a light boron element. Using first-principles combined with the Boltzmann transport theory, we have shown that in contrast to graphene or black phosphorus, the boron monolayer has a low lattice thermal conductivity arising from its complex crystal of hexagonal vacancies. The conduction band with an intrinsic camelback shape leads to the high DOS and a high n-type Seebeck coefficient, while the highly degenerate valence band along with the small hole effective mass contributes to the high p-type power factor. As a result, we obtained the p-type thermoelectric figure of merit up to 0.96 at 300 K, indicating that the boron monolayer is a promising p-type thermoelectric material.
Continuous Synthesis of Uniformly Dispersed Mesoporous SBA-15 Supported Silver Nanoparticles in a Coiled Flow Inverter Reactor
Authors: Zhu Hai , Wu Ke-Jun , He Chao-Hong 
Published: September 2021

Mesoporous silica supported nanocatalysts have shown great potential in industrial processes due to their unique properties, such as high surface area, large pore volume, good chemomechanical stability and so on. Controllable and tunable synthesis of supported nanocatalysts is a crucial problem. Continuous synthesis of supported nanoparticles has been reported to get uniformly dispersed nanomaterials. Here, a method for continuous synthesis of uniformly dispersed mesoporous SBA-15 supported silver nanoparticles in a coiled flow inverter (CFI) microreactor is described. Compared to Ag/SBA-15 synthesized in the conventional batch reactor and Ag synthesized in continuous flow, mesoporous silica nanocatalysts synthesized in continuous flow are found to have smaller average size (7–11 nm) and narrower size distribution. The addition of capping agents can effectively change the characteristic of catalysts. Moreover, two kinds of support with different surface area and pore size have been added into the continuous synthesis. This method can provide further understandings for the synthesis of uniformly dispersed supported nanocatalysts in continuous flow, especially for mesoporous nanomaterials, which provides the possibilities of large-scale yield process of supported nanocatalysts in industry.
The Clinical Impact of Proton Pump Inhibitors When Co-Administered With Dual Antiplatelet Therapy in Patients Having Acute Myocardial Infarction With Low Risk of Gastrointestinal Bleeding: Insights From the China Acute Myocardial Infarction Registry
Authors: Shi Wence , Ni Lin , Yang Jingang , Fan Xiaoxue , Yu Mei , Yang Hongmei , Yu Mengyue , Yang Yuejin ,   China Acute Myocardial Infarction (CAMI) Registry study group
Published: September 2021

Background: The latest guidelines recommend the use of proton pump inhibitors (PPIs) to minimize gastrointestinal bleeding (GIB) in patients receiving dual antiplatelet therapy (DAPT), even though this co-administration may increase the risk of ischemia due to drug interactions. We have noticed that there are few studies conducted on patients with a lower risk of GIB. Therefore, we investigated the clinical effect of co-administration of PPI on DAPT patients with low GIB risk.Methods and Results: From January 2013 to September 2014, a total of 17,274 consecutive patients on DAPT from 108 hospitals with low risk for GIB in the China Acute Myocardial Infarction (CAMI) registry were analyzed. The primary endpoints were GIB and major adverse cardiovascular and cerebrovascular events (MACCE). Multivariate logistic regression analysis and Cox proportional hazard models were used to assess the effect of PPIs use. Of the analyzed patients, 66.6% (n = 11,487) were treated with PPIs. PPI use did not show an extra gastrointestinal protective effect in patients with low risk for GIB who were hospitalized and on follow-up after 2 years. Moreover, it was associated with an increased risk of stroke during the 2-year follow-up [hazard ratio (HR) 2.072, 95% confidence interval (CI) 1.388–3.091, p = 0.0003] and an increased risk of MI after 6 months (HR 1.580, 95% CI 1.102–2.265, p = 0.0119). We found the same results after propensity score matching.Conclusion: PPI use is prevalent in DAPT patients with low GIB risk. PPIs did not show an extra gastrointestinal protective effect, while an increased risk of stroke was observed during the 2-year follow-up.Clinical Trial Registration:www.clinicaltrials.gov, identifier NCT01874691.
Sex-Specific Exposure–Effect Relationship Between Physical Activity and Incident Atrial Fibrillation in the General Population: A Dose–Response Meta-Analysis of 16 Prospective Studies
Authors: Wan Qin , Zhou Yue , Zhu Wengen , Liu Xiao 
Published: September 2021

Background: Since evidence regarding the relationship between physical activity (PA) and atrial fibrillation (AF) incidence is inconsistent among studies, we performed a dose–response meta-analysis to comprehensively evaluate the exposure–effect association between PA and incident AF and the potential sex difference in the general population.Methods: The PubMed and Embase databases were searched for eligible studies published up to July 2020 (PROSPERO: CRD42018091692). The non-linear or linear exposure–effect relationship between PA and AF was examined using the robust error meta-regression method.Results: A total of 16 prospective studies involving 1,449,017 individuals and 39,884 AF cases were included. We observed an inverse non-linear association between PA level and incident AF (I2 = 0%, pnon−linearity &lt; 0.001). In the linear model, a 5 metabolic equivalent of task (MET)-h/week increase in PA was associated with a decreased risk of AF [risk ratio (RR) = 0.992, 95% confidence interval (CI): 0.988–0.996, I2 = 0%]. In the sex-stratified analysis, we observed an inverse non-linear relationship between PA level and AF risk in females (I2 = 90%, pnon−linearity &lt; 0.0001) but not in males (I2 = 0%, pnon−linearity = 0.40). In the linear model, a 5 MET-h/week increase in PA was associated with a reduced risk of AF in females (RR = 0.982, 95% CI: 0.975–0.989, I2 = 71%) but not in males (RR = 0.998, 95% CI: 0.994–1.002, I2 = 0%), with a significant interaction observed between the two groups (pinteraction &lt; 0.0001).Conclusion: There was an inverse non-linear relationship between PA level and incident AF in the general population. The beneficial effect of PA in reducing AF risk might be predominantly observed in females.
Identification and Validation of EMT-Related lncRNA Prognostic Signature for Colorectal Cancer
Authors: Li Danfeng , Lin Xiaosheng , Chen Binlie , Ma Zhiyan , Zeng Yongming , Wang Huaiming 
Published: September 2021

Background: This study aimed to explore the biological functions and prognostic role of Epithelial-mesenchymal transition (Epithelial-mesenchymal transition)-related lncRNAs in colorectal cancer (CRC).Methods: The Cancer Genome Atlas database was applied to retrieve gene expression data and clinical information. An EMT-related lncRNA risk signature was constructed relying on univariate Cox regression, Least Absolute Shrinkage and Selector Operation (LASSO) and multivariate Cox regression analysis of the EMT-related lncRNA expression data and clinical information. Then, an individualized prognostic prediction model based on the nomogram was developed and the predictive accuracy and discriminative ability of the nomogram were determined by the receiver operating characteristic curve and calibration curve. Finally, a series of analyses, such as functional analysis and unsupervised cluster analysis, were conducted to explore the influence of independent lncRNAs on CRC.Results: A total of 581 patients were enrolled and an eleven-EMT-related lncRNA risk signature was identified relying on the comprehensive analysis of the EMT-related lncRNA expression data and clinical information in the training cohort. Then, risk scores were calculated to divide patients into high and low-risk groups, and the Kaplan-Meier curve analysis showed that low-risk patients tended to have better overall survival (OS). Multivariate Cox regression analysis indicated that the EMT-related lncRNA signature was significantly associated with prognosis. The results were subsequently confirmed in the validation dataset. Then, we constructed and validated a predictive nomogram for overall survival based on the clinical factors and risk signature. Functional characterization confirmed this signature could predict immune-related phenotype and was associated with immune cell infiltration (i.e., macrophages M0, M1, Tregs, CD4 memory resting cells, and neutrophils), tumor mutation burden (TMB).Conclusions: Our study highlighted the value of the 11-EMT-lncRNA signature as a predictor of prognosis and immunotherapeutic response in CRC.
Development and Validation of a Novel Gene Signature for Predicting the Prognosis by Identifying m5C Modification Subtypes of Cervical Cancer
Authors: Yu Jing , Liang Lei-Lei , Liu Jing , Liu Ting-Ting , Li Jian , Xiu Lin , Zeng Jia , Wang Tian-Tian , Wang Di , Liang Li-Jun , Xie Da-Wei , Chen Ding-Xiong , An Ju-Sheng , Wu Ling-Ying 
Published: September 2021

Background: 5-Methylcytidine (m5C) is the most common RNA modification and plays an important role in multiple tumors including cervical cancer (CC). We aimed to develop a novel gene signature by identifying m5C modification subtypes of CC to better predict the prognosis of patients.Methods: We obtained the expression of 13 m5C regulatory factors from The Cancer Genome Atlas (TCGA all set, 257 patients) to determine m5C modification subtypes by the “nonnegative matrix factorization” (NMF). Then the “limma” package was used to identify differentially expressed genes (DEGs) between different subtypes. According to these DEGs, we performed Cox regression and Kaplan-Meier (KM) survival analysis to establish a novel gene signature in TCGA training set (128 patients). We also verified the risk prediction effect of gene signature in TCGA test set (129 patients), TCGA all set (257 patients) and GSE44001 (300 patients). Furthermore, a nomogram including this gene signature and clinicopathological parameters was established to predict the individual survival rate. Finally, the expression and function of these signature genes were explored by qRT-PCR, immunohistochemistry (IHC) and proliferation, colony formation, migration and invasion assays.Results: Based on consistent clustering of 13 m5C-modified genes, CC was divided into two subtypes (C1 and C2) and the C1 subtype had a worse prognosis. The 4-gene signature comprising FNDC3A, VEGFA, OPN3 and CPE was constructed. In TCGA training set and three validation sets, we found the prognosis of patients in the low-risk group was much better than that in the high-risk group. A nomogram incorporating the gene signature and T stage was constructed, and the calibration plot suggested that it could accurately predict the survival rate. The expression levels of FNDC3A, VEGFA, OPN3 and CPE were all high in cervical cancer tissues. Downregulation of FNDC3A, VEGFA or CPE expression suppressed the proliferation, migration and invasion of SiHa cells.Conclusions: Two m5C modification subtypes of CC were identified and then a 4-gene signature was established, which provide new feasible methods for clinical risk assessment and targeted therapies for CC.
Construction of a Prognostic Model in Lung Adenocarcinoma Based on Ferroptosis-Related Genes
Authors: Liang Min , Chen Mafeng , Zhong Yinghua , Singh Shivank , Singh Shantanu 
Published: September 2021

Background: Lung adenocarcinoma is one of the most common malignant tumors of the respiratory system, ranking first in morbidity and mortality among all cancers. This study aims to establish a ferroptosis-related gene-based prognostic model to investigate the potential prognosis of lung adenocarcinoma.Methods: We obtained gene expression data with matching clinical data of lung adenocarcinoma from the The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The ferroptosis-related genes (FRGs) were downloaded from three subgroups in the ferroptosis database. Using gene expression differential analysis, univariate Cox regression, and LASSO regression analysis, seven FRGs with prognostic significance were identified. The result of multivariate Cox analysis was utilized to calculate regression coefficients and establish a risk-score formula that divided patients with lung adenocarcinoma into high-risk and low-risk groups. The TCGA results were validated using GEO data sets. Then we observed that patients divided in the low-risk group lived longer than the overall survival (OS) of the other. Then we developed a novel nomogram including age, gender, clinical stage, TNM stage, and risk score.Results: The areas under the curves (AUCs) for 3- and 5-years OS predicted by the model were 0.823 and 0.852, respectively. Calibration plots and decision curve analysis also confirmed the excellent predictive performance of the model. Subsequently, gene function enrichment analysis revealed that the identified FRGs are important in DNA replication, cell cycle regulation, cell adhesion, chromosomal mutation, oxidative phosphorylation, P53 signaling pathway, and proteasome processes.Conclusions: Our results verified the prognostic significance of FRGs in patients with lung adenocarcinoma, which may regulate tumor progression in a variety of pathways.
Chemical Tuning on Resonance Coupling in Gold Nanorod−Monolayer WS2 Heterostructures
Authors: Wen Shiya , Deng Shiyu , Chen Kun , Chen Huanjun , Deng Shaozhi 
Published: September 2021

Resonance coupling between plasmonic resonances in metallic nanostructures and excitons in two-dimensional (2D) semiconductors has attracted much recent attention. The 2D semiconductor excitons are sensitive to external stimulus, enabling active tuning on the resonance couplings by physical, such as applying electrostatic gating, thermal scanning, etc., or chemical approaches. Among the others, chemical tuning approach has the advantage of facile implementation, high efficiency, and being capable of large-area tuning. Here, we report on chemical tuning of resonance coupling in heterostructures consisted of individual gold nanorods integrated with monolayer WS2. We showed that by incubating the heterostructures into a bis (trifluoro-methane) sulfonimide (TFSI) solution, the exciton transition strength of the WS2 will be enhanced significantly. As a result, the resonance coupling in the heterostructures evolved from a weak coupling regime to a strong coupling one, with the mode splitting energy increases from 94.96 to 105.32 meV. These findings highlight the potential of chemical treatment as an efficient technique for tailoring the interactions between plasmonic nanostructures and 2D semiconductors.
RNA m1A Methyltransferase TRMT6 Predicts Poorer Prognosis and Promotes Malignant Behavior in Glioma
Authors: Wang Beibei , Niu Lihua , Wang Zhengyang , Zhao Zhihua 
Published: September 2021

Background: Glioma is the most prevalent central nervous system tumor in humans, and its prognosis remains unsatisfactory due to a lack of effective therapeutic targets. The ectopic expression of N1-methyladenosine (m1A) regulators is a key participant in tumorigenesis and progression. However, the m1A regulator expression status, prognostic value, and relationship with tumor clinical features in glioma remain unclear.Methods: Public datasets were used to analyze the mRNA and protein expression levels of m1A regulators. Kaplan–Meier and Cox regression analyses were performed to confirm the prognostic value of m1A regulators in glioma. Cellular experiments were conducted to verify the effect of TRMT6 on cell function. A comprehensive bioinformatics analysis was conducted to identify the potential molecular mechanisms regulated by TEMT6 in glioma.Results: We found that the dysregulation of m1A regulators was closely associated with tumorigenesis and progression in glioma. Furthermore, TRMT6 might be a powerful and independent biomarker for prognosis in glioma. Our study showed that inhibition of TRMT6 suppressed the proliferation, migration, and invasion of glioma cells. Mechanistically, TRMT6 may be involved in glioma progression by regulating cell cycle, PI3K-AKT, TGF-beta, MTORC1, NOTCH, and MYC pathways.Conclusions: Variation in m1A regulators was closely associated with malignant progression in glioma. Silencing TRMT6 suppressed the cell proliferation, migration, and invasion in glioma. m1A regulators, especially TRMT6, might play an essential role in the malignant progression of glioma.
Effects of Obstructive Sleep Apnea Syndrome and Medical Comorbidities on Language Abilities
Authors: Makanikas Konstantinos , Andreou Georgia , Simos Panagiotis , Chartomatsidou Efstathia 
Published: September 2021

Objective: The primary objective of the present cross-sectional study is to evaluate the semantic language abilities of patients with Obstructive Sleep Apnea Syndrome (OSAS) compared to normative data. Secondary objectives are to examine the effects of OSAS comorbidities on language test performance.Method: 118 adult patients suffering from OSAS were assessed using standardized tests (Boston Naming Test, the Peabody Picture Vocabulary Test and the Verbal Fluency Test).Results: Compared to normative standards, the OSAS group (age and education adjusted mean) scored significantly lower on all tests (p &lt; 0.01). The OSAS group also included a significantly higher percentage of persons scoring below the 5th percentile of the normative distribution on the four tests (p &lt; 0.01). The Apnea/Hypopnea Index, O2 Desaturation index, SaO2 &lt;85% (min) and SaO2 &lt;75% (min) were significantly associated with language test scores (p &lt; 0.05). Moreover, higher Apnea–Hypopnea Index score and night-time oxygen desaturation were associated with reduced phonemic and semantic fluency performance only among patients with a history of hypertension and hypercholesterolemia (p &lt; 0.05). The moderating effect of diabetes and cardiovascular disease on the association between OSAS severity indices and test scores did not reach significance (p &gt; 0.6).Conclusions: Results suggest that the severity of semantic language impairments in patients with OSAS is associated with the severity of the disease and intensified by common medical comorbidities (hypertension and hypercholesterolemia).
Task Complexity and Image Clarity Facilitate Motor and Visuo-Motor Activities in Mirror Therapy in Post-stroke Patients
Authors: Bello Umar Muhammad , Chan Chetwyn C. H. , Winser Stanley John 
Published: September 2021

Introduction:Mirror therapy is effective in the recovery of upper-limb function among post-stroke patients. An important component of mirror therapy is imagining finger movements. This study aimed to determine the influence of finger movement complexity and mirror image clarity on facilitating motor and visuo-motor activities in post-stroke patients.Methods:Fifteen post-stroke patients and 18 right-handed healthy participants performed simple or complex finger tapping while viewing mirror images of these movements at varying levels of clarity. The physical setup was identical to typical mirror therapy. Functional near infrared spectroscopy (fNIRS) was used to capture the brain activities elicited in the bilateral primary motor cortices (M1) and the precuneus using a block experimental design.Results:In both study groups, the “complex finger-tapping task with blurred mirror image” condition resulted in lower intensity (p&lt; 0.01) and authenticity (p&lt; 0.01) of the kinesthetic mirror illusion, and higher levels of perceived effort in generating the illusion (p&lt; 0.01), relative to the “simple finger-tapping with clear mirror image” condition. Greater changes in the oxygenated hemoglobin (HbO) concentration were recorded at the ipsilesional and ipsilateral M1 in the “complex finger-tapping task with blurred mirror image” condition relative to that recorded in the “simple finger-tapping task with clear mirror image” condition (p= 0.03). These HbO concentration changes were not significant in the precuneus. Post-stroke patients showed greater changes than their healthy counterparts at the ipsilesional M1 (F= 5.08;p= 0.03; partial eta squared = 0.14) and the precuneus (F= 7.71;p&lt; 0.01; partial eta squared = 0.20).Conclusion:The complexity and image clarity of the finger movements increased the neural activities in the ipsilesional motor cortex in the post-stroke patients. These findings suggest plausible roles for top-down attention and working memory in the treatment effects of mirror therapy. Future research can aim to corroborate these findings by using a longitudinal design to examine the use of mirror therapy to promote upper limb motor recovery in post-stroke patients.