bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of diarrhea of goats and their concurrent blood profile in north west region of Bangladesh
Authors: Ali Md Erman , Sujan Khaled Mahmud , Rasel Imrul Hasan , Islam Md Kamrul 
Published: May 2021

In Bangladesh, Diarrhea occurs in goats of any age and is responsible for poor growth in kids and a significant loss of production both through morbidity and mortality. The study was undertaken to determine the clinical prevalence of diarrheal diseases of goats with concurrent blood profile. A total of 1,007 goats were examined which were brought for treatment in the Upazilla Veterinary Hospital, Biral, Dinajpur. Among them 149 goats were found clinically affected by diarrhea and the overall prevalence of diarrheal disease in goats was 14.80%. A total of 402 male and 605 female goats were examined and their diarrheal prevalence were 14.17%, 15.15%, respectively. The Prevalence in Jamnapari goat (18.80%) was signicantly (P<0.01) higher than in Black Bengal goats (14.26%). The prevalence (59.52%) in suckler (below 3 months) was much significantly (P<0.001) higher than in young (12.47%) and adults (13.42%). Higher prevalence was found due to parasitic infection (38.25%) with a declining order in PPR (30.20%), overfeeding (24.16%) and poisoning (7.30%). The leukocyte number significantly (P<0.001) higher in goats affected by diarrhea whereas TEC, PCV, Hb and Erythrocyte Indices were in normal ranges. From this study, it can be concluded that suckler, female goats and Jamnapari goats are more susceptible to diarrhea than adult, male goats and Black Bengal goats.
Asian J. Med. Biol. Res. March 2021, 7(1): 6-11
The correlation of bone mineral density, body mass index and age
Authors: Sultana S , Hasan Mohammad Nayeem , Taleb MA 
Published: May 2021

Osteoporosis is related to the decrease in bone mineral density. To diagnose osteoporosis and to assess its severity BMD measurement is a widely used method by using dual-energy X-ray absorptiometry (DEXA). BMD is an essential component of the assessment of bone quality and is utilized to assess the osteoporotic status of the bone for the prevention of osteoporotic fractures. The objective of this study was assessed to analyze the correlation between BMD with BMI and age. The study was conducted on 154 patients who performed the BMD test between the periods of January 2018 to July 2019. BMD of the lumbar spine (LS) and right femoral neck (FN) were measured using the DEXA method. In statistical analysis, the BMD status was compared according to age, gender, and BMI. Correlation among BMD, BMI, and age was analyzed with the nonparametric method (spearman rank correlation). SPSS software version 25 was used for analysis. Age showed highly significant negative correlations with all skeletal sites examined. Assessments on the T-score of FN and BMI were significantly related (p<0.05, r=0.223, positive relation). T-score of LS and BMI were positively correlated (r=0.484) and it was significant at a 95% level of significance. Both FN and LS T-score and showed a negative correlation, but it was significant. BMI and age were not significantly associated (p>0.05, r=-0.080, negative relation). As expected, the FN T-score and LS T-score showed a high correlation (r=0.484) between each other, and they were positive. Significant correlations were observed among BMD, BMI, and age of the patients. To identify the cause of osteoporosis, BMI and patients age can be considered as risk factors during BMD study. Our hope is that future research will reveal osteoporosis prevention targets effective for the growing population of aging men and women.
Asian J. Med. Biol. Res. March 2021, 7(1): 76-81
Tanggap Siaga Dalam Masa Pandemi Covid-19 Desa Tempursari Kabupaten Magelang
Authors: Nuraini Paramita , Pratiwi Atri , Gusti Kevin , Silvita Novina , Fauziah Arinda 
Published: May 2021

Abstract:Corona virus is a type of influenza virus or a common virus that causes infection of the nose, sinuses or upper throat. The Covid-19 virus in humans is most commonly transmitted from an infected person to another in a number of ways. This virus can be transmitted easily through the air by coughing and sneezing. However, it can also be through direct contact such as shaking hands, touching objects and so on. Indonesia is one of the countries where the spread of the corona 19 virus is relatively fast. This virus also causes the death of victims, therefore education is needed related to preparedness during the Covid 19 Pandemic. This activity was held in Tempursari village, Magelang Regency for 1 month (June 2020) involving 1 assistant lecturer and 4 students of the Guidance and Counseling study program. Muhammadiyah University of Magelang as a companion for counseling and simulations related to proper hand washing and the use of proper masks. This service activity is expected for the community to have insight into the dangers of Covid 19 and have skills related to proper hand washing procedures and the use of proper masks so that they can reduce the spread of Covid 19, especially in Magelang district.Keywords: alert response; covid pandemic 19; wash hands Abstrak:Virus Corona merupakan sejenis virus influenza atau virus umum yang menyebabkan infeksi pada hidung, sinus atau tenggorokan bagian atas.Virus Covid-19 pada manusia paling umum menular dari orang yang terinfeksi ke orang lain melalui berbagai cara. Virus ini dapat menular dengan mudah melalui udara dengan batuk dan bersin. Namun, bisa juga melalui kontak langsung seperti berjabat tangan, menyentuh benda dan lain sebagainya. Indonesia merupakan salah satu negara yang penyebaran Virus Covid-19 terhitung cepat. Virus ini juga menyebabkan kematian terhadap korban, karena itu perlu adanya edukasi terkait tanggap siaga dalam masa Pandemi Covid 19. Kegiatan ini dilaksankan di desa Tempursari Kabupaten Magelang selama 1 bulan ( juni 2020) dengan melibatkan 1 dosen pendamping dan 4 mahasiswa program studi Bimbingan dan Konseling Universitas Muhammadiyah Magelang sebagai pendamping penyuluhan dan simulasi terkait cuci tangan yang benar dan penggunaan masker yang tepat. Kegiatan pengabdian ini diharapkan masyarakat memiliki wawasan terkait bahaya covid 19 dan memiliki ketrampilan terkait tata cara cuci tangan yang benar dan penggunaan masker yang tepat sehingga dapat menekan penyebaran Covid-19 khususnya di kabupaten Magelang.Kata kunci: cuci tangan; pandemi covid-19; tanggap siaga
Ação antifúngica de extratos e frações de Annona muricata L. sobre Candida spp.
Authors: Cesar Kellyane Karen Ferreira Aguiar , Batista Anny Karoline Rodrigues , Paula Luciana Rocha , Silva Reginara Teixeira da , Silva Francisco Laurindo da 
Published: May 2021

Devido ao amplo potencial medicinal de Annona muricata, as pesquisas relacionadas às suas aplicações em diferentes áreas ligadas a saúde são de fundamental importância, principalmente no que se refere a microrganismos infecciosos com tendências a desenvolver mecanismos de resistência, que é o caso de algumas espécies do gênero Candida. Nesse sentido, a pesquisa tem como principal objetivo verificar a ação antifúngica de extratos metanólicos de Annona muricata sobre Candida albicans, Candida parapsilosis, Candida krusei e Candida glabrata. Os órgãos utilizados para obtenção dos extratos metanólicos foram a folha e o fruto da Annona muricata. Para a realização da pesquisa, foram utilizadas cepas ATCC, que foram reativadas e cultivadas em Ágar Saboraud Dextrose. A determinação da atividade antifúngica dos extratos foi realizada pela técnica da difusão em ágar em poços. Na análise dos resultados, os valores de mensuração dos diâmetros dos halos indicaram uma ação mais significativa nos testes realizados com as espécies de C. krusei e C. albicans frente aos extratos brutos da folha e do fruto de A. muricata, com halo de 30mm e 22mm respectivamente. Em relação ao fracionamento químico realizado, os produtos obtidos a partir das frações butanólica e hexánica da folha sobre cepas de C. krusei, C. albicans e C. parapsilosis foram os que apresentaram resultados mais significativos. Dessa forma, comprovou-se que substancias presentes nesse vegetal podem ser utilizadas no controle cepas de Candida, contudo, estudos mais aprofundados são necessários para identificação e isolamento dos compostos biológicos ativos desses vegetais.
“Partiu estágio!” Relato de experiência de uma acadêmica de enfermagem
Authors: Gomes Liliane de Almeida , Sampaio Daniela Márcia Neri , Simões Aline Vieira , Ribeiro Vívian Mara 
Published: May 2021

Objetivo: Conhecer, a partir do relato de experiência de uma acadêmica do curso de Graduação em Enfermagem, as contribuições que o programa do governo do estado, “Partiu Estágio”, proporcionou na sua formação acadêmica e identificar as lacunas na execução do referido programa. Métodos: Trata-se de um estudo qualitativo, descritivo, do tipo relato de experiência, que ocorreu em um hospital de grande porte de um município baiano, situado na região sudoeste do Estado, através do programa “Partiu Estágio”. Resultados: As experiências vivenciadas durante o período de abril de 2018 a abril de 2019, assegurou a acadêmica uma formação diferenciada na realidade do Sistema Único de Saúde, dentre elas podemos elencar a Parceria Público-Privada. Conclusão: Essa experiência enriqueceu o arcabouço pessoal e profissional da mesma ao possibilitar superação de desafios, contornar situações adversas e tomada decisão, tendo como resultado o aprimoramento do senso crítico e do convívio interpessoal no ambiente de trabalho. Assim, ressalta-se a relevância da participação de acadêmicas (os) em programas de estágios extracurriculares para possibilitar uma formação crítico-reflexiva, priorizando os princípios e diretrizes do Sistema Único de Saúde; como também a necessidade em ampliar diálogos entre a gestão de programas de estágio do governo do estado, com as instituições de educação superior e instituições concedente do estágio.
Cuidando do cuidador: Um relato de experiência de intervenções de boas práticas de saúde para profissionais da atenção primária da linha frente na COVID-19
Authors: Melo Tereza Cristina Linhares Costa , Sampaio Ana Claudia Costa de , Albuquerque Neto Francisco Walter de , Santos Jorge Luís Rodrigues dos , Alves Paloma Carvalho , Gadelha Lizianea de Aragão , Costa Silvinha de Sousa Vasconcelos , Araújo Carlos Romualdo de Carvalho e , Vasconcelos Ana Kelly Cândido , Ferreira Francisco Valdicélio 
Published: May 2021

Introdução: Relata-se a experiência da intervenção em saúde denominada: “Cuidando do cuidador”, junto a profissionais da equipe mínima de um Centro de Saúde da Família (CSF). A aplicação desta intervenção teve como objetivo propiciar incentivo, apoio e autocuidado aos profissionais da unidade da linha de frente da pandemia da Covid-19. Metodologia: Trata-se de estudo descritivo e qualitativo, realizado no Centro de Saúde da Família, Dr. Grijalba Mendes Carneiro, localizado em Sobral, zona Norte do Ceará, no mês de outubro de 2020. A intervenção dividiu-se em momentos de aplicação técnicas de relaxamento, com alongamentos, massagens, musicoterapia e meditação guiada, além de educação em saúde com residentes da unidade. Participaram da intervenção: agentes comunitários de saúde, enfermeiros, auxiliares administrativos, técnicos de enfermagem e médico. Resultados: Após a intervenção, foi perceptível a diminuição da tensão destes profissionais, pois precisavam de autocuidado, relaxamento físico e mental após a sobrecarga exaustiva do trabalho na pandemia Covid-19. Os participantes relataram desejo que tais práticas acontecessem com regularidade no CSF. Conclusão: A intervenção mostrou-se relevante ao melhor bem-estar físico e mental desses profissionais, ao reduzir estresse e tensão decorrentes da sobrecarga laboral pandêmica. Assim, promoveu-se autocuidado àqueles que tanto se doam para cuidar do outro.
Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels and Cardiometabolic Risk Factors: A Population-Based Cohort Study
Authors: Shi Jie , Li Xiaoyong , Zhang Weiwei , Niu Yixin , Lin Ning , Zhang Hongmei , Ning Guang , Fan Jiangao , Qin Li , Su Qing , Yang Zhen 
Published: May 2021

Aims: To evaluate the prospective association of circulating PCSK9 levels with the cardiometabolic risk profiles (high LDL-cholesterol, high triglycerides, low HDL-cholesterol, hypertension, type 2 diabetes, and metabolic syndrome).Methods: A population-based prospective study was conducted among 7,104 Chinese individuals (age 56.2 ± 7.5 years; 32.0% men). Circulating PCSK9 levels were measured using ELISA.Results: Circulating PCSK9 levels were higher in women than men (286.7 ± 90.1 vs. 276.1 ± 86.4 ng/ml, p &lt; 0.001). And circulating PCSK9 was positively correlated with LDL-cholesterol, total cholesterol, and triglycerides both in men and women (all p &lt; 0.001). The positive correlation between PCSK9 and waist circumference, fasting glucose, insulin resistance, systolic blood pressure, diastolic blood pressure and C-reactive protein (all p &lt; 0.01) was observed in women only. According to Cox regression analysis, circulating PCSK9 was positively associated with incidence of high LDL-cholesterol both in men (HR 1.33, 95% CI 1.09–1.65, p &lt; 0.001) and women (HR 1.36, 95% CI 1.12–1.69, p &lt; 0.001). Moreover, PCSK9 was significantly associated with incident high triglycerides (HR 1.31, 95% CI 1.13–1.72, p &lt; 0.001), hypertension (HR 1.28, 95% CI 1.08–1.53, p = 0.011), type 2 diabetes (HR 1.34, 95% CI 1.09–1.76, p = 0.005), and metabolic syndrome (HR 1.30, 95% CI 1.11–1.65, p = 0.009) per SD change in women only. No statistically significant association was observed between circulating PCSK9 and incidence of low HDL-cholesterol (p &gt; 0.1).Conclusions: Elevated circulating PCSK9 was significantly associated with cardiometabolic risk factors and independently contributed to the prediction of cardiometabolic risks in women.
Predictive Value of Thyroglobulin Changes for the Curative Effect of Radioiodine Therapy in Patients With Metastatic Differentiated Thyroid Carcinoma
Authors: Wang Congcong , Zhang Ruiguo , Wang Renfei , Meng Zhaowei , Zhang Guizhi , Dong Feng , He Yajing , Tan Jian 
Published: May 2021

BackgroundSerum thyroglobulin (Tg) serves as a sensitive and easily available tumor marker for patients with metastatic differentiated thyroid carcinoma (m-DTC). The aim of the present study was to evaluate the predictive value of suppressed Tg changes (Δsup-Tg) and/or stimulated Tg changes (Δsti-Tg) to evaluate the efficacy of radioiodine therapy (RT).MethodsWe studied 117 patients with m-DTC who received RT. Δsup-Tg and Δsti-Tg were compared after the first RT in different therapeutic response groups and a receiver-operating characteristic (ROC) curve was used to determine the cut-off values to predict non-remission. Univariate and multivariate analyses were used to investigate the effects of 17 observed factors on the efficacy of RT.ResultsA total of 218 RT events in 117 patients with m-DTC were analyzed. After the last RT, the remission rate was 70.94% (83/117), and the proportion of remission events accounted for 74.77% (163/218). ROC curve analysis showed that the cut-off values for Δsup-Tg and Δsti-Tg after the first RT to predict the non-remission of RT were 21.54% and 27.63%, respectively. Age, the size of the metastasis, the maximum count of target metastatic lesions and the average count of contralateral non-target tissue on tomographic imaging (Tmax/NTmean) of the first RT, and Δsup-Tg after the first RT were identified as independent factors associated with RT efficacy.ConclusionsTg response was valuable to predict RT efficacy for patients with m-DTC. Age, the size of the metastasis, Tmax/NTmean, and Δsup-Tg after the first RT were verified as independent predictive factors of RT efficacy.
Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study
Authors: Nellis Marianne E. , Vasovic Ljiljana V. , Goel Ruchika , Karam Oliver 
Published: May 2021

Objectives: Children supported by extracorporeal membrane oxygenation (ECMO) are at high risk of bleeding. Though practitioners often prescribe blood components and/or medications to prevent or treat bleeding, the utilization of these hemostatic measures in children is not well-understood. We sought to evaluate the use of hemostatic blood products (platelet, plasma and cryoprecipitate transfusions) and medications [aminocaproic acid, tranexamic acid (TXA) and Factor VIIa] in children supported by ECMO.Design: Retrospective observational study using the Pediatric Health Information System (PHIS) database from 2011-2017.Setting: Fifty-one U.S. children's hospitals.Patients: Children (aged 0–18 years) supported by ECMO.Interventions: None.Measurements and Main Results: ECMO was employed in the care of 7,910 children for a total of 56,079 ECMO days. Fifty-five percent of the patients were male with a median (IQR) age of 0 (0–2) years. The median (IQR) length of ECMO was 5 (2–9) days with a hospital mortality rate of 34%. Platelets were transfused on 49% of ECMO days, plasma on 33% of ECMO days and cryoprecipitate on 17% of ECMO days. Twenty-two percent of children received TXA with the majority receiving it on the first day of ECMO and the use of TXA increased during the 6-year period studied (p &lt; 0.001). Seven percent of children received aminocaproic acid and 3% received Factor VIIa.Conclusions: Children supported by ECMO are exposed to a significant number of hemostatic blood products. Antifibrinolytics, in particular TXA, are being used more frequently. Given the known morbidity and mortality associated with hemostatic blood products, studies are warranted to evaluate the effectiveness of hemostatic strategies.
Intermittent Theta Burst Stimulation (iTBS) as an Optimal Treatment for Schizophrenia Risk Decision: an ERSP Study
Authors: Wu Yang , Wang Lu , Yu Fengqiong , Ji Gong-Jun , Xiao Guixian , Feifei Xu , Chunyan Zhu , Xingui Chen , Wang Kai 
Published: May 2021

Objective: People with schizophrenia have serious impairments in social function, especially in decision-making ability. Transcranial magnetic stimulation modified intermittent theta burst transcranial magnetic stimulation (iTBS) has been shown to regulate the functional connection of brain networks. Our study explored the therapeutic effect of iTBS on decision-making disorders in schizophrenia.Methods: Participants were pseudorandomized and assigned to iTBS (n = 16) or sham (n = 16) group. iTBS group was administered 1,800 pulses on the target of the left dorsol lateral prefrontal cortex (L-DLPFC) per day for 14 consecutive days. We compared Iowa gambling task performance and associated event-related spectral perturbation results (ERSP) among two groups.Results: The results show that participants' performance in the high-lose in the iTBS group had stronger stimulation of theta spectral power than those in the sham group. Specifically, we found that under high-risk conditions, compared with the control group, the iTBS group showed significant activation of the theta spectrum power in the FPZ, FZ, FCZ, and CZ regions after treatment.Conclusions: Our results provide evidence that long-term iTBS stimulation effectively improves the decision-making ability of schizophrenia. After receiving negative feedback, patients can turn to safety options. These findings support that iTBS may be a potential treatment for clinical decision-making disorders.
Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat
Authors: Rodríguez-Mortera Reyna , Caccavello Russell , Hermo Ricardo , Garay-Sevilla María Eugenia , Gugliucci Alejandro 
Published: May 2021

Tightly regulated iron metabolism prevents oxidative stress. Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation. It inhibits iron entry into the circulation by blocking dietary absorption in the duodenum, the release of recycled iron from macrophages and the exit of stored iron from hepatocytes. Varied signals responding to iron stores, erythropoietic activity and host defense converge to regulate hepcidin production and thereby affect iron homeostasis. Although it is known that hepcidin increases when interleukin 6 (IL-6) increases, the relationship between hepcidin, dyslipidemia, insulin resistance (IR) and visceral adiposity index (VAI) in adolescents with obesity is unclear. In this cross-sectional study of 29 obese adolescents and 30 control subjects, we explored the difference of hepcidin, iron metabolism markers and IL-6 between obese and non-obese adolescents, and identified associations with inflammation, atherogenic dyslipidemia and IR. As compared to lean controls, obese participants showed 67% higher hepcidin: 14,070.8 ± 7213.5 vs. 8419.1 ± 4826.1 pg/mLc; 70% higher ferritin: 94.4 ± 82.4 vs. 55.1 ± 39.6 pg/mLa and 120% higher IL-6: 2.0 (1.1–4.9) vs. 0.9 (0.5–1.3) pg/mLd. Transferrin, soluble transferrin receptor and total body iron (as measured by sTFR/ferritin, log10 sTFR/ferritin ratio and sTFR/log ferritin ratios) were not different between the two cohorts. In the whole cohort, hepcidin correlated with VAI (r = 0.29a), sd-LDL (r = 0.31b), HOMA-IR (r = 0.29a) and IL-6 (r = 0.35c). In obese adolescents hepcidin correlated with TG (r = 0.47b), VLDL-C (r = 0.43b) and smaller LDL2 (r = 0.39a). Hepcidin elevation in adolescents with obesity is linked more to inflammation and metabolic alterations than to iron metabolism since the other markers of iron metabolism were not different between groups, except for ferritin. Studies addressing the long-term effects of higher hepcidin levels and their impact on subclinical anemia and iron status are warranted. a p < 0.05; b p < 0.01, c p < 0.001 dp < 0.0001.
Volatiles and Antifungal-Antibacterial-Antiviral Activity of South African Salvia spp. Essential Oils Cultivated in Uniform Conditions
Authors: Najar Basma , Mecacci Giulia , Nardi Valeria , Cervelli Claudio , Nardoni Simona , Mancianti Francesca , Ebani Valentina Virginia , Giannecchini Simone , Pistelli Luisa 
Published: May 2021

Spontaneous emissions of S. dentata Aiton and S. scabra Thunb., as well as the essential oil (EO) composition of the cited species, together with S. aurea L., were investigated. The chemical profile of the first two species is reported here for the first time. Moreover, in vitro tests were performed to evaluate the antifungal activity of these EOs on Trichophyton mentagrophytes, Microsporum canis, Aspergillus flavus, Aspergillus niger, and Fusarium solani. Secondly, the EO antibacterial activity against Escherichia coli, Staphylococcus aureus, and Staphylococcus pseudointermedius was examined, and their antiviral efficacy against the H1N1 influenza virus was assessed. Leaf volatile organic compounds (VOCs), as well as the EOs obtained from the arial part of Salvia scabra, were characterized by a high percentage of sesquiterpene hydrocarbons (97.8% and 76.6%, respectively), mostly represented by an equal amount of germacrene D (32.8% and 32.7%, respectively). Both leaf and flower spontaneous emissions of S. dentata, as well as the EO composition, showed a prevalence of monoterpenes divided into a more or less equal amount of hydrocarbon and oxygenated compounds. Interestingly, its EO had a non-negligible percentage of oxygenated sesquiterpenes (29.5%). S. aurea EO, on the contrary, was rich in sesquiterpenes, both hydrocarbons and oxygenated compounds (41.5% and 33.5%, respectively). S. dentata EO showed good efficacy (Minimal Inhibitory Concentration (MIC): 0.5%) against M. canis. The tested EOs were not active against E. coli and S. aureus, whereas a low inhibition of S. dentata EO was observed on S. pseudointermedius (MIC = 10%). Once again, S. dentata EO showed a very good H1N1 inhibition; contrariwise, S. aurea EO was completely inactive against this virus. The low quantity of S. scabra EO made it impossible to test its biological activity. S. dentata EO exhibited interesting new perspectives for medicinal and industrial uses.