bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer
Authors: Cui Huaiping , Jiang Zhaoyu , Zeng Shujie , Wu Hao , Zhang Zihao , Guo Xiaobo , Dong Kangdi , Wang Jinshen , Shang Liang , Li Leping 
Published: October 2021

AbstractAs oncogenes and tumor suppressor genes, long non-coding RNAs (lncRNAs) regulate the biological behavior of gastric cancer (GC) cells such as proliferation, invasion, and metastasis through various signal pathways. At present, although numerous lncRNAs that significantly influence the development and progression of GC have been identified, a considerable number of them have not been found and studied yet. In this study, we identified a new lncRNA derived from pseudogenes WFDC21P, which have not been reported in any previous GC study. LncRNA WFDC21P was significantly upregulated in GC cells and tissues, and clinically associated with the pathological stages of advanced GC. WFDC21P promoted proliferation and metastasis of GC cells both in vitro and in vivo. LncRNA WFDC21P was directly bound to GTPase Ran and it promoted the activity of the Akt/GSK3β/β-catenin pathway. Forkhead Box P3 (FOXP3), as a transcription factor of WFDC21P, was directly bound to the promoter region and it positively regulated the transcription of WFDC21P. This finding may provide a novel biomarker and therapeutic target for GC.
An ANN‐based channel modeling in 5G millimeter wave for a high‐voltage substation
Authors: Fu Zihao , Zhang Yu , Zhao Xiongwen , Du Fei , Geng Suiyan , Qin Peng , Zhou Zhenyu , Zhang Lei , Chen Suhong 
Published: October 2021

AbstractIn this work, an artificial neural network (ANN) based time‐varying channel modeling framework is proposed, including a playback model and a prediction model. The purpose of the ANN‐based modeling framework is to playback 5G measured radio channels at certain measurement positions, and further predict large scale channel parameters (LSCPs) at unmeasured positions with limited amount of measurement data. 28 GHz channel measurements were also conducted at a high‐voltage substation for the first time worldwide to meet with 5G radio system deployment for China Energy Internet. Meanwhile, the performance of the playback channels is evaluated by comparison with the measurements and traditional geometry based stochastic modeling (GBSM) simulated channels. An optimized radial basis function (ORBF) ANN is applied in the prediction model, and the predicted LSCPs are compared with the other approaches, which shows that the ORBF has the best performance. This work offers a solution to predict radio channels and parameters in case of big measured or simulated channel datasets.
The observed multiplicity properties of B-type stars in the Galactic young open cluster NGC 6231
Authors: Banyard G. , Sana H. , Mahy L. , Bodensteiner J. , Villaseñor J. I. , Evans C. J. 
Published: October 2021

Context. It is well known that massive O stars are frequently (if not always) found in binary or higher-order multiple systems, but this fact has been less robustly investigated for the lower mass range of the massive stars, represented by B-type stars. Obtaining the binary fraction and orbital parameter distributions of B-type stars is crucial to understand the impact of multiplicity on the archetypal progenitor of core-collapse supernovae as well as to properly investigate formation channels for gravitational wave progenitors.
Aims. This work aims to characterise the multiplicity of the B star population of the young open cluster NGC 6231 through multi-epoch optical spectroscopy of 80 B-type stars.
Methods. We analyse 31 FLAMES/GIRAFFE observations of 80 B-type stars, monitoring their radial velocities (RVs) and performing a least-squares spectral analysis (Lomb-Scargle) to search for periodicity in those stars with statistically significant variability in their RVs.
Results. We constrained an observed spectroscopic binary fraction of 33 ± 5% for the B-type stars of NGC 6231, with a first order bias correction giving a true spectroscopic binary fraction of 52 ± 8%. Out of 27 B-type binary candidates, we obtained orbital solutions for 20 systems: 15 single-lined (SB1) and five double-lined spectroscopic binaries (SB2s). We present these orbital solutions and the orbital parameter distributions associated with them.
Conclusions. Our results indicate that Galactic B-type stars are less frequently found in binary systems than their more massive O-type counterparts, but their orbital properties generally resemble those of B- and O-type stars in both the Galaxy and Large Magellanic Cloud.
Reduzindo as transfusões de sangue em pacientes com artroplastia total primária do quadril: A eficácia dos testes rápidos de Hb e uma clínica especializada em anemia pré-operatória
Authors: Sandean Darren , Samaras Michail , Chatterji Urjit , Power Richard , Qureshi Hafiz 
Published: October 2021

Resumo
Objetivo A anemia pré-operatória em pacientes ortopédicos, está associada a maiores taxas de transfusão de sangue alogênico, resultando em desfechos mais desfavoráveis. Até 25% dos pacientes encaminhados para cirurgia ortopédica de grande porte, apresentam algum grau de anemia. O controle adequado do sangue do paciente no perioperatório é essencial, a fim de reduzir as sequelas da anemia e a necessidade de transfusões. Avaliamos a eficácia do teste rápido, em conjunto com uma clínica especializada no tratamento da anemia pré-operatória, com o objetivo de detectar e tratar a anemia dos pacientes a serem submetidos a artroplastia total primária do quadril.
Métodos A comparação das taxas totais de transfusão de sangue alogênico, foi realizada em pacientes submetidos a artroplastia total primária do quadril, antes e depois da implementação dos testes rápidos e da clínica especializada no tratamento da anemia pré-operatória ao longo de um ano. Também foi feita uma comparação entre os pacientes com anemia, que foram encaminhados para a clínica, com aqueles que não foram encaminhados. Foram revisados os níveis de hemoglobina pré-operatória, as taxas de transfusão de sangue alogênico e o tratamento clínico em 1.095 pacientes.
Resultados Houve uma redução significativa nas taxas de transfusão, em pacientes submetidos à ATQ primária, caindo de 10,0% para 6,2% (p <0,05, teste χ2), após a implementação do teste rápido e da clínica especializada em anemia pré-operatória. A taxa de transfusão de sangue alogênico para pacientes anêmicos tratados na clínica foi de 6,7%, em comparação com 26,9% para pacientes anêmicos no pré-operatório, que não foram tratados na clínica (p <0,05, teste exato de Fisher). Em média, o tratamento na clínica aumentou a taxa de hemoglobina dos pacientes em 20 g/L, passando de 104 g/L para 124 g/L p <0,001.
Conclusões O teste rápido, juntamente com a clínica especializada no tratamento da anemia pré-operatória, reduziu a necessidade de transfusão de sangue alogênico perioperatório, em pacientes submetidos a artroplastia total primária do quadril, proporcionando uma identificação rápida e um tratamento eficaz da anemia pré-operatória.
Deformidade de Madelung – Resultado estético e funcional do tratamento cirúrgico com osteotomia em cúpula do rádio distal e secção do ligamento de Vickers
Authors: Carvalho Marcos , Cardoso Pedro Sá , Alves Cristina , Balacó Inês , Ling Tah Pu , Matos Gabriel 
Published: October 2021

Resumo
Objetivo Avaliar o resultado estético e funcional do tratamento cirúrgico da deformidade de Madelung em idade pediátrica.
Método Estudo retrospectivo dos pacientes com deformidade de Madelung em idade pediátrica tratados cirurgicamente através de osteotomia em cúpula do rádio distal e secção do ligamento de Vickers entre 2015 e 2018. Foram incluídos doentes com tempo de seguimento pós-operatório mínimo de 12 meses. Foram analisados dados demográficos, técnica cirúrgica, resultados clínicos e radiográficos. A avaliação radiográfica pré e pós-operatória consistiu na medição da inclinação ulnar, do afundamento semilunar, do ângulo da fossa semilunar e do desvio palmar do carpo. A avaliação clínica pós-operatória consistiu na medição das amplitudes articulares do punho, escala visual analógica (EVA) e score Disabilities of the Arm, Shoulder and Hand (DASH).
Resultados Foram incluídos quatro pacientes, dois com Madelung idiopática e dois com displasia óssea, todos do sexo feminino e com doença bilateral. Foram operados 6 punhos, a idade mediana à data de cirurgia foi 15,5 anos, e o tempo mediano de seguimento pós-operatório foi de 37,5 meses. Na análise radiográfica pós-operatória, verificou-se uma correção média de 8,8 ± 7,5° da inclinação ulnar, de 3 ± 3,9 mm do afundamento semilunar, de 8,2 ± 6,6° do ângulo da fossa semilunar e de 4,7 ± 2,6 mm do desvio palmar do carpo. Na avaliação da amplitude articular média pós-operatória, registrou-se uma flexão de 75,8 ± 3,4°; extensão de 62,5 ± 14,1°; desvio radial de 25,7 ± 2,9°; desvio cubital de 40,0 ± 2,9; pronação de 88,3 ± 2,4°; supinação de 82,5 ± 2,5°. Registou-se EVA mediana para dor residual = 1, défice funcional = 0, prejuízo estético = 0, e recomendação de procedimento cirúrgico = 10. A mediana do score DASH foi 0.
Conclusão O tratamento da deformidade de Madelung através da osteotomia em cúpula do rádio distal e secção do ligamento de Vickers permite obter um excelente resultado estético e funcional.
Periodontitis and Helicobacter pylori Infection: Eradication and Periodontal Therapy Combination
Authors: Tsimpiris Athanasios , Grigoriadis Andreas , Tsolianos Ioannis , Moschos Ioannis , Goulis Dimitrios G. , Kouklakis Georgios 
Published: October 2021

Abstract
Objectives This study was aimed to assess (1) the prevalence of salivary and gastric Helicobacter pylori (HP) infection in patients with and without periodontitis, (2) the prevalence of HP infection in patients with periodontitis according to its clinical classification, (3) the effect of periodontitis treatment in patients with or without gastric HP infection, and (4) if gastric HP eradication in combination with periodontitis treatment influences periodontitis clinical outcome.
Materials and Methods Thirty-three adults with periodontitis treated by quadrant scaling and root planning (QSRP). The simplified plaque index (PI), bleeding on probing index (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed pretreatment and 3 months of posttreatment. The patients were tested for oral and gastric HP. Gastric HP (+) patients received eradication therapy. A control group of 32 periodontically healthy volunteers was tested for oral and gastric HP. Saliva samples were evaluated by real-time polymerase chain reaction (rtPCR); gastric HP was detected by urea breath test (UBT).
Statistical Analysis Normality of variables assessed by the Kolmogorov–Smirnov test, while the differences of pre- and post-treatment were analyzed by paired samples t-test. Differences between subgroups were compared by a Student’s t-test or a Mann–Whitney U-test. Comparisons of nominal variables were made by Pearson’s Chi-square test.
Results No saliva samples were positive for HP. Gastric HP was detected in six patients with periodontitis and seven controls (p > 0.05). HP infection affected patients with higher disease stages and grades. All HP (+) patients underwent successful eradication treatment. All clinical periodontitis indices improved following QSRP. HP (+) patients who received QSRP as adjunctive to eradication treatment showed improvement in BOP (p < 0.001), PI (p < 0.013), and CAL (p < 0.004) compared with HP (−) patients who received QSRP alone.
Conclusion Periodontitis was not associated with gastric HP infection. Saliva was not a gastric HP supply reservoir. Gastric HP infection was associated with advanced stages and grades of periodontitis. Although all periodontal clinical markers improved after QSRP, BOP, PI, and CAL, they were further improved when combined with eradication treatment. Periodontal evaluation and treatment combined with HP eradication are recommended in patients with HP gastric infection.
Esthetic Rehabilitation of Anterior Dentition with Different Types of Ceramic Restorations: Two Case Reports
Authors: Krump Michal , Krumpova Zelmira 
Published: October 2021

AbstractAll-ceramic systems represent an excellent restorative alternative for fixed dental prostheses, single crowns, and veneers in the anterior dentition. With respect to improved mechanical properties, lithium disilicate ceramic material provide a broad range of indications, and extended veneers can serve as an alternative to full crowns. Although ceramic veneers represent a more conservative approach compared to crowns, the correct indication is essential to achieving the ideal outcome. The following case reports describe two types of fixed restorations of the anterior dentition: extended lithium disilicate ceramic veneers and lithium disilicate full crowns. Factors influencing treatment selection for each type of restorations are presented.
Osteoarticular Infection of the Shoulder Joint Due to Trichophyton Spp. in a Dog
Authors: Feline Julien Alexandre , Cabassu Julien Bernard 
Published: October 2021

AbstractA 10-year-old Labrador Retriever was referred for persistent lameness due to chronic right shoulder pain, unresponsive to various pain management therapies. Radiographs indicated signs of severe degenerative changes in the joint. Synovial fluid analysis was not diagnostic. Septic arthritis was suspected based on computed tomography and clinical signs. Arthroscopy allowed joint exploration, tissue biopsies, and copious joint lavage. Trichophyton spp. proliferation was identified on antimicrobial culture and histological analysis on samples obtained during arthroscopy. Oral griseofulvin therapy was initiated. Two months later, the referring veterinarian decided to interrupt the treatment after a negative synovial culture despite persistent lameness. Euthanasia was elected upon after pain also appeared on the tarsus; a post-mortem exam was not authorized by the owner. The origin of the infection remains unclear as this patient had no skin lesions and its immunological status was unknown. However, dermatophytosis has been reported in healthy dogs without skin lesions. To the author's knowledge, this is the first report of an osteoarticular infection with a dermatophyte in a dog.
Using Machine Learning to Capture Quality Metrics from Natural Language: A Case Study of Diabetic Eye Exams
Authors: Fong Allan , Scoulios Nicholas , Blumenthal H. Joseph , Anderson Ryan E. 
Published: October 2021

Abstract
Background and Objective The prevalence of value-based payment models has led to an increased use of the electronic health record to capture quality measures, necessitating additional documentation requirements for providers.
Methods This case study uses text mining and natural language processing techniques to identify the timely completion of diabetic eye exams (DEEs) from 26,203 unique clinician notes for reporting as an electronic clinical quality measure (eCQM). Logistic regression and support vector machine (SVM) using unbalanced and balanced datasets, using the synthetic minority over-sampling technique (SMOTE) algorithm, were evaluated on precision, recall, sensitivity, and f1-score for classifying records positive for DEE. We then integrate a high precision DEE model to evaluate free-text clinical narratives from our clinical EHR system.
Results Logistic regression and SVM models had comparable f1-score and specificity metrics with models trained and validated with no oversampling favoring precision over recall. SVM with and without oversampling resulted in the best precision, 0.96, and recall, 0.85, respectively. These two SVM models were applied to the unannotated 31,585 text segments representing 24,823 unique records and 13,714 unique patients. The number of records classified as positive for DEE using the SVM models ranged from 667 to 8,935 (2.7–36% out of 24,823, respectively). Unique patients classified as positive for DEE ranged from 3.5 to 41.8% highlighting the potential utility of these models.
Discussion We believe the impact of oversampling on SVM model performance to be caused by the potential of overfitting of the SVM SMOTE model on the synthesized data and the data synthesis process. However, the specificities of SVM with and without SMOTE were comparable, suggesting both models were confident in their negative predictions. By prioritizing to implement the SVM model with higher precision over sensitivity or recall in the categorization of DEEs, we can provide a highly reliable pool of results that can be documented through automation, reducing the burden of secondary review. Although the focus of this work was on completed DEEs, this method could be applied to completing other necessary documentation by extracting information from natural language in clinician notes.
Conclusion By enabling the capture of data for eCQMs from documentation generated by usual clinical practice, this work represents a case study in how such techniques can be leveraged to drive quality without increasing clinician work.
Two-dimensional retrieval methods for ultrafast imaging of molecular structure using laser-induced electron diffraction
Authors: Wang Su-Ju , Daněk Jiří , Blaga Cosmin I. , DiMauro Louis F. , Biegert Jens , Lin C. D. 
Published: October 2021

Molecular structural retrieval based on electron diffraction has been proposed to determine the atomic positions of molecules with sub-angstrom spatial and femtosecond temporal resolutions. Given its success on small molecular systems, in this work, we point out that the accuracy of structure retrieval is constrained by the availability of a wide range of experimental data in the momentum space in all molecular systems. To mitigate the limitations, for laser-induced electron diffraction, here we retrieve molecular structures using two-dimensional (energy and angle) electron momentum spectra in the laboratory frame for a number of small molecular systems, which have previously been studied with 1D methods. Compared to the conventional single-energy or single-angle analysis, our 2D methods effectively expand the momentum range of the measured data. Besides utilization of the 2D data, two complementary methods are developed for consistency check on the retrieved results. The 2D nature of our methods also offers a way of estimating the error from retrieval, which has never been explored before. Comparing with results from prior experiments, our findings show evidence that our 2D methods outperform the conventional 1D methods. Paving the way to the retrieval of large molecular systems, in which their tunneling ionization rates are challenging to obtain, we estimate the error of using the isotropic model in place of including the orientation-dependent ionization rate.
Global urban population exposure to extreme heat
Authors: Tuholske Cascade , Caylor Kelly , Funk Chris , Verdin Andrew , Sweeney Stuart , Grace Kathryn , Peterson Pete , Evans Tom 
Published: October 2021

Significance
Increased extreme heat exposure from both climate change and the urban heat island effect threatens rapidly growing urban settlements worldwide. Yet, because we do not know where urban population growth and extreme heat intersect, we have limited capacity to reduce the impacts of urban extreme heat exposure. Here, we leverage fine-resolution temperature and population data to measure urban extreme heat exposure for 13,115 cities from 1983 to 2016. Globally, urban exposure increased nearly 200%, affecting 1.7 billion people. Total urban warming elevated exposure rates 52% above population growth alone. However, spatially heterogeneous exposure patterns highlight an urgent need for locally tailored adaptations and early warning systems to reduce harm from urban extreme heat exposure across the planet’s diverse urban settlements.
Eighteen-month-old infants represent nonlocal syntactic dependencies
Authors: Perkins Laurel , Lidz Jeffrey 
Published: October 2021

SignificanceAs mature speakers of a language, we are able to produce and understand an indefinite number of sentences. This ability comes from a powerful cognitive system—syntax—whose properties reveal the types of computations that human minds can engage in. One core property is the capacity to encode abstract grammatical dependencies that can hold at a distance. When does this property emerge in development? We identify a nonlocal dependency that 18-mo-old infants, but not younger infants, represent syntactically. These findings suggest that the second year of life is a period of active syntactic development and that even before they regularly produce full sentences of their own, infants demonstrate some of the core computational capacities that syntax relies on.
Characterization and operational stability of EJ276 plastic scintillator-based detector for neutron spectroscopy
Authors: McCormack O. , Giacomelli L. , Croci G. , Muraro A. , Gorini G. , Grosso G. , Pasqualotto R. , Perelli Cippo E. , Rebai M. , Rigamonti D. , Tardocchi M. 
Published: October 2021

Abstract
A state-of-the-art EJ276 plastic scintillator-based detector
for neutron spectroscopy has undergone detailed characterization
both in a controlled laboratory and on-site at the SPIDER negative
ion source facility in Padua. The device will be used for the
spectroscopy of 2.5 MeV neutrons produced from Deuterium-Deuterium
fusion reactions occurring inside the SPIDER beam dump. A plastic
based scintillator with neutron/gamma discrimination has some key
advantages over the commonly used organic liquid scintillators with
regards economic cost and handling safety. The purpose of this
characterization is to determine the operational functionality and
reliability of this new breed of detector material. Several tests
were performed to verify expected operation with regards to signal
reproducibility, long-term stability, and pulse shape discrimination
(PSD) capabilities. It was found that the detector system (EJ276
scintillator + photomultiplier tube) performed well in terms of
reproducibility and PSD, however the long-term stability of the
scintillator light output was seen to diminish considerably over
time (>50% decrease) and must be consistently
monitored in order to have an accurate conversion scale needed for
energy spectroscopy.
High-voltage pulse modulated radio frequency generator for dielectric barrier discharge combined with ultra-fast high power pulse generator
Authors: Flaxer E. 
Published: October 2021

Abstract
Dielectric barrier discharge is the electrical discharge
between two electrodes separated by an insulating dielectric
barrier. The discharge process typically uses a high-voltage
alternating current in the range of several kilohertz to several
gigahertz. A high-frequency and high-power pulse generator is
required to drive the discharge process through the capacitance
load. There are two main techniques to implement this type of
generator: the forced and resonant modes. This work demonstrates the
implementation of a programmable digital circuit based on a digital
signal controller and a full H-bridge that combines the two
topologies and can be used as a controller for dielectric barrier
discharge with varying capacitance and structure. We integrated an
ultra-fast, high-resolution, and high-power pulse generator into a
radio frequency generator to drive high-pressure, supersonic, pulsed
valves. The excitation based on our DBD and the combined generator
produces cold plasma beams. The controller generates discharge
voltages of up to 5 kV, in pulses of 10 to 50 μs wide, at
rates of up to 1 kHz, while the discharge frequency ranges are from
1 to 3 MHz under a capacitive load of 100 pF. The power generator
applies a current pulse of up to 20 A and voltage of up to 150 V.