bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing transfusion management of multiple myeloma patients receiving daratumumab‐based regimens
Authors: Phou Samantha , Costello Caitlin , Kopko Patricia M. , Allen Elizabeth S. 
Published: May 2021

AbstractBackgroundDaratumumab, a human anti‐CD38 monoclonal antibody used to treat multiple myeloma, interferes with pretransfusion testing and can mask alloantibodies. Incidence of alloimmunization in patients on daratumumab has not been well characterized, and optimal transfusion guidelines regarding prophylactic antigen matching, accounting for both patient safety and efficiency, have not been well established for these patients.MethodsRecords of patients who received daratumumab between January 1, 2014 and July 2, 2019 were reviewed. Daratumumab interference with pretransfusion testing was managed by testing with reagent red blood cells (RBCs) treated with 0.2 M dithiothreitol. When daratumumab was present during antibody testing, patients were transfused with RBC units prophylactically matched for D, C, c, E, e, and K antigens per hospital policy.ResultsOut of 90 patients identified, 52 received a total of 638 RBC transfusions (average of 12.3 units per patient, SD 17.2, range 1–105, median 5 among those transfused). Alloantibodies existing before daratumumab initiation were identified in seven patients. No new alloantibodies were detected in any patients after starting daratumumab treatment.ConclusionsThe incidence of alloimmunization in patients receiving daratumumab is low. Whether this is due to the effect of daratumumab, underlying pathophysiology, or other factors, is unknown. Because these patients require a large number of RBC transfusions overall and have little observed alloimmunization, phenotype matching (beyond RhD) may be unnecessary. Since the use of dithiothreitol cannot rule out the presence of anti‐K, we recommend transfusion of ABO‐compatible units, prophylactically matched for the D and K antigens only.
Familial pseudohyperkalemia induces significantly higher levels of extracellular potassium in early storage of red cell concentrates without affecting other standard measures of quality: A case control and allele frequency study
Authors: Meli Athinoula , McAndrew Margaret , Frary Amy , Rehnstrom Karola , Stevens‐Hernandez Christian J. , Flatt Joanna F. , Griffiths Alexandra , Stefanucci Luca , Astle William , Anand Rekha , New Helen V. , Bruce Lesley J. , Cardigan Rebecca 
Published: May 2021

AbstractBackgroundFamilial pseudohyperkalemia (FP) is characterized by an increased rate of potassium leakage in refrigerated red cells and is associated with the minor allele of the single nucleotide polymorphism rs148211042 (R723Q) in the ABCB6 gene. The study aims were to obtain the minor allele frequencies of ABCB6 variants and to measure supernatant potassium accumulation, and other red cell storage parameters, in red cell concentrates (RCC) from carriers of variant rs148211042 under standard blood bank conditions.Study DesignWhole blood units were collected from 6 FP individuals and 11 controls and processed into RCC in additive solution. RCC were sampled and tested over cold storage for full blood count, extracellular potassium, glucose, lactate, microvesicle release, deformability, hemolysis, pH, adenosine triphosphate, and 2,3‐diphosphoglycerate.ResultsScreening of genotyped cohorts identified that variant rs148211042 is present in 1 in 394 British citizens of European ancestry. FP RCC had significantly higher supernatant potassium at all time points from day 3 onwards (p < .001) and higher mean cell volume (p = .032) than controls. The initial rate of potassium release was higher in FP RCC; supernatant potassium reached 46.0 (23.8–57.6) mmol/L (mean [range]) by day 5, increasing to 68.9 (58.8–73.7) mmol/L by day 35. Other quality parameters were not significantly different between FP RCC and controls.ConclusionThese data suggest that if a blood donor has FP, reducing the RCC shelf‐life to 5 days may be insufficient to reduce the risk of hyperkalemia in clinical scenarios such as neonatal large volume transfusion.
Retrospective investigation of the neutrophil‐to‐lymphocyte ratio in dogs with pneumonia: 49 cases (2011–2016)
Authors: Conway Elizabeth A. , Pizarro Del Valle Carlos , Waugh Elspeth M. , French Anne , Ridyard Alison E. 
Published: May 2021

AbstractObjectiveTo assess the utility of the neutrophil‐to‐lymphocyte ratio (NLR) in predicting outcome in canine pneumonia compared with routine hematological parameters and systemic inflammatory response syndrome (SIRS) scores.DesignRetrospective study.SettingUniversity teaching hospital.AnimalsForty‐nine client‐owned dogs.InterventionsNoneMeasurements and Main ResultsMedical records were reviewed to identify dogs with a diagnosis of pneumonia from July 2011 to December 2016. Signalment, clinical findings, laboratory characteristics, and outcome were recorded. Inclusion criteria were a clinical and radiographic diagnosis of pneumonia, plus reference laboratory hematology at diagnosis. Cases that received steroids were excluded. Euthanized dogs were only included in statistical analysis if euthanized solely due to pneumonia severity. The NLR, total WBC count, neutrophil count, lymphocyte count, band neutrophil percent of total WBC count (%‐bands), and percentage of cases diagnosed with SIRS were compared between survivors and nonsurvivors. Receiver operating characteristic curves were generated to identify optimal sensitivity and specificity cutoffs for nonsurvival to discharge.Two hundred records were retrieved; 49 cases fulfilled the inclusion criteria. Of these, 33 (67%) survived to discharge. The NLR did not differ significantly between the survivors and nonsurvivors, nor did total WBC count or neutrophil count. Survivors had a significantly lower %‐bands than nonsurvivors (P < 0.001) and higher lymphocyte count (P = 0.004). The mortality rate did not differ significantly between dogs with and without SIRS. Receiver operating characteristic analysis identified a %‐bands cutoff of 2.5% or higher had an 83% sensitivity and 79% specificity for nonsurvival.ConclusionsUnlike in human medicine, neither NLR nor SIRS scores predicted outcome in this cohort of dogs with pneumonia. However, survivors had a lower %‐bands and higher lymphocyte count than nonsurvivors, which may be helpful prognostically in clinical cases.
Autoresuscitation and pheochromocytoma multisystem crisis in a dog
Authors: Kato Michael T. , Mallard John M. 
Published: May 2021

AbstractObjectiveTo describe the clinical course of a dog with a pheochromocytoma multisystem crisis that exhibited autoresuscitation after cardiac arrest.Case SummaryAn approximately 10‐year‐old male neutered terrier mix dog presented for collapse. Abdominal imaging was suggestive of a pheochromocytoma, and clinical pathology data and thoracic imaging suggested the presence of a multisystem crisis. The dog developed cardiopulmonary arrest that was followed by autoresuscitation.New or Unique Information ProvidedTo the authors’ knowledge, this is the first report of autoresuscitation in a dog. The phenomenon may have been associated with a pheochromocytoma multisystem crisis.
V-Shaped Holes for Full Coverage Film Cooling of a High-Pressure Nozzle Guide Vane
Authors: Barigozzi G. , Abdeh H. , Rouina S. , Abba L. , Iannone M. , Odemondo V. 
Published: May 2021

AbstractThis paper describes an experimental activity carried out to investigate the potential of V-shaped holes for film cooling a high-pressure nozzle guide vane. The newly designed V-shaped scheme was compared with standard laidback fan-shaped holes. The influence of showerhead cooling was also assessed. Different injection conditions were examined under the same cascade operating condition using CO2 as a coolant. The quality of holes geometry and their discharging behavior was first characterized. Then, dual-luminophore pressure-sensitive paint (PSP) was used for measuring the adiabatic film cooling effectiveness all over the vane surface. Results of the current work showed that using a V-shaped hole configuration would give nearly the same surface protection as standard shaped holes with a reduced number of holes and, thus, at lower coolant flow consumption.
Numerical Modeling of the Interaction of Moving Fish Nets and Fluid
Authors: Martin Tobias , Wang Gang , Bihs Hans 
Published: May 2021

Abstract
The significant difference in length scales between the flow around a moving fish net and the flow around each twine of the net prevents the resolution of the complete structure within a discrete fluid domain. In this article, this issue is overcome by calculating the net and fluid dynamics separately and incorporate their interaction implicitly. The forces on the net are approximated using a screen force model, and the motion of the net is computed with a lumped mass method. Here, a linear system of equations is derived from the dynamic equilibria and kinematic relations. The net model is coupled to the computational fluid dynamics (CFD) solver reef3d, which solves the incompressible Navier–Stokes equations using high-order finite differences in space and time. Several numerical calculations are provided, and the comparison of loads and velocity reduction with available measurements indicates the good performance of the proposed model.
A Modular Mechanism for Downhole Weight-on-Bit and Torque Reaction in Small Diameter Boreholes
Authors: Mazumdar Anirban , Buerger Stephen P. , Foris Adam J. , Su Jiann-Cherng 
Published: May 2021

Abstract
Drilling systems that use downhole rotation must react torque either through the drill-string or near the motor to achieve effective drilling performance. Problems with drill-string loading such as buckling, friction, and twist become more severe as hole diameter decreases. Therefore, for small holes, reacting torque downhole without interfering with the application of weight-on-bit, is preferred. In this paper, we present a novel mechanism that enables effective and controllable downhole weight on bit transmission and torque reaction. This scalable design achieves its unique performance through four key features: (1) mechanical advantage based on geometry, (2) direction dependent behavior using rolling and sliding contact, (3) modular scalability by combining modules in series, and (4) torque reaction and weight on bit that are proportional to applied axial force. As a result, simple mechanical devices can be used to react large torques while allowing controlled force to be transmitted to the drill bit. We outline our design, provide theoretical predictions of performance, and validate the results using full-scale testing. The experimental results include laboratory studies as well as limited field testing using a percussive hammer. These results demonstrate effective torque reaction, axial force transmission, favorable scaling with multiple modules, and predictable performance that is proportional to applied force.
Efficient Global Sensitivity Analysis of Model-Based Ultrasonic Nondestructive Testing Systems Using Machine Learning and Sobol’ Indices
Authors: Nagawkar Jethro , Leifsson Leifur 
Published: May 2021

Abstract
The objective of this work is to reduce the cost of performing model-based sensitivity analysis for ultrasonic nondestructive testing systems by replacing the accurate physics-based model with machine learning (ML) algorithms and quickly compute Sobol’ indices. The ML algorithms considered in this work are neural networks (NNs), convolutional NN (CNNs), and deep Gaussian processes (DGPs). The performance of these algorithms is measured by the root mean-squared error on a fixed number of testing points and by the number of high-fidelity samples required to reach a target accuracy. The algorithms are compared on three ultrasonic testing benchmark cases with three uncertainty parameters, namely, spherically void defect under a focused and a planar transducer and spherical-inclusion defect under a focused transducer. The results show that NNs required 35, 100, and 35 samples for the three cases, respectively. CNNs required 35, 100, and 56, respectively, while DGPs required 84, 84, and 56, respectively.
Experimental and Numerical Analysis of the Transient Behavior of the Oil Decongealing Process in an Aero Fuel-Cooled Oil Cooler Under Low-Temperature Conditions
Authors: Kholi Foster Kwame , Park Jaehyun , Lee Kyeongho , Ha Man Yeong , Klingsporn Michael , Chetwynd-Chatwin Jason , Yoon Sang Youl , Min June Kee 
Published: May 2021

Abstract
The fuel-cooled oil cooler (FCOC) in the lubrication circuit plays a critical role in the aero gas-turbine engine's aerothermal management. However, the low temperature of the operating environment can congeal the oil and reduce the FCOC efficiency. The oil bypass valve (OBV) installed on the FCOC prevents pressure loss. Its failure may cause overheating, requiring preemptive performance prediction. Experimental and numerical analyses were used to evaluate the cooler's decongealing performance under typical boundary conditions of pressure and temperature, OBV configurations, and rerouting of feed oil and fuel flow paths. The temporal variation of oil and fuel mass flow rates, temperature, and pressure of the feed oil and fuel provided an insight into the decongealing process and duration. The experimental data were used to develop a one-dimensional (1D) flow and thermal network analysis model based on the effectiveness (ε)-number of thermal units (NTU) method to predict the transient oil decongealing performance of the FCOC. The customized commercial code predicted the decongealing phenomena using empirical correlations with property correction schemes, showing good agreement with the experiment. The findings revealed various ways to enhance the decongealing performance of the FCOC. The study results showed that the operating boundary conditions, OBV location and status, and flow arrangements affect decongealing behavior and time. The present numerical model provides results quickly and can effectively predict experimentally costly and complicated cases. The attempted estimates of steady heat rejection and detailed methodology could guide future studies and practical applications.
Leakage and Rotordynamic Characteristics for Three Types of Annular Gas Seals Operating in Supercritical CO2 Turbomachinery
Authors: Li Zhigang , Li Zhuocong , Li Jun , Feng Zhenping 
Published: May 2021

Abstract
The balance piston seal in multiple-stage centrifugal compressors and axial turbines sustains the largest pressure drop through the machines and therefore plays an important role in successful full load operation at high rotational speed. This is especially true for power dense turbomachines in supercritical CO2 power cycles that generate or expend higher fluid pressures (above the critical value 7.3 MPa) and density (close to water 1000 kg/m3), because the fluid forces generated by the balance piston seals are directly proportional to the fluid density and the pressure drop across the seal. This paper presents a comprehensive assessment and comparison on the leakage and rotordynamic performance of three types of annular gas seals for application in a 14 MW supercritical CO2 turbine. These three seals represent the main seal types used in high-speed rotating machines at the balance piston location in efforts to limit internal leakage flow and achieve rotordynamic stability, including a labyrinth seal (LABY), a fully partitioned pocket damper seal (FPDS), and a hole-pattern damper seal (HPS). These three seals were designed to have the same sealing clearance and similar axial lengths. To enhance the seal net damping capability at high inlet preswirl condition, a straight swirl brake was also designed and employed at seal entrance for each type seal to reduce the seal inlet preswirl velocity. Numerical results of leakage flow rates, rotordynamic force coefficients, cavity dynamic pressure, and swirl velocity developments were analyzed and compared for three seal designs at high positive inlet preswirl (in the direction of shaft rotation), using a proposed transient computational fluid dynamic (CFD)-based perturbation method based on the multiple-frequency elliptical-orbit rotor whirling model and the mesh deformation technique. To take into account of real gas effect with high accuracy, a table look-up procedure based on the National Institute of Standards and Technology reference fluid properties database was implemented, using an in-house code, for the fluid properties of CO2 in both supercritical and subcritical conditions. Results show that the inlet swirl brake can significantly reduce the preswirl velocity at seal entrance, lowering the effective damping crossover frequency fco (or even fco = 0) to maximize the full operational frequency range of the machines. In stability analysis phase of a MW-scale supercritical CO2 turbine/compressor, the seal stiffness effects on the rotor mode shape must be evaluated carefully, where the seal stiffness is sufficiently large (comparable to the bearing stiffness). From a rotordynamic viewpoint, the HPS seal with entrance swirl brake is a better seal concept for the balance piston seal in supercritical CO2 turbomachinery, which possesses the largest positive effective damping throughout the entire subsynchronous frequency range.
Geomorphic expression and slip rate of the Fairweather fault, southeast Alaska, and evidence for predecessors of the 1958 rupture
Authors: Witter Robert C. , Bender Adrian M. , Scharer Katherine M. , DuRoss Christopher B. , Haeussler Peter J. , Lease Richard O. 
Published: May 2021

AbstractActive traces of the southern Fairweather fault were revealed by light detection and ranging (lidar) and show evidence for transpressional deformation between North America and the Yakutat block in southeast Alaska. We map the Holocene geomorphic expression of tectonic deformation along the southern 30 km of the Fairweather fault, which ruptured in the 1958 moment magnitude 7.8 earthquake. Digital maps of surficial geology, geomorphology, and active faults illustrate both strike-slip and dip-slip deformation styles within a 10°–30° double restraining bend where the southern Fairweather fault steps offshore to the Queen Charlotte fault. We measure offset landforms along the fault and calibrate legacy 14C data to reassess the rate of Holocene strike-slip motion (≥49 mm/yr), which corroborates published estimates that place most of the plate boundary motion on the Fairweather fault. Our slip-rate estimates allow a component of oblique-reverse motion to be accommodated by contractional structures west of the Fairweather fault consistent with geodetic block models. Stratigraphic and structural relations in hand-dug excavations across two active fault strands provide an incomplete paleoseismic record including evidence for up to six surface ruptures in the past 5600 years, and at least two to four events in the past 810 years. The incomplete record suggests an earthquake recurrence interval of ≥270 years—much longer than intervals &lt;100 years implied by published slip rates and expected earthquake displacements. Our paleoseismic observations and map of active traces of the southern Fairweather fault illustrate the complexity of transpressional deformation and seismic potential along one of Earth's fastest strike-slip plate boundaries.
Detrital zircon record of Phanerozoic magmatism in the southern Central Andes
Authors: Capaldi T.N. , McKenzie N.R. , Horton B.K. , Mackaman-Lofland C. , Colleps C.L. , Stockli D.F. 
Published: May 2021

Abstract
The spatial and temporal distribution of arc magmatism and associated isotopic variations provide insights into the Phanerozoic history of the western margin of South America during major shifts in Andean and pre-Andean plate interactions. We integrated detrital zircon U-Th-Pb and Hf isotopic results across continental magmatic arc systems of Chile and western Argentina (28°S–33°S) with igneous bedrock geochronologic and zircon Hf isotope results to define isotopic signatures linked to changes in continental margin processes. Key tectonic phases included: Paleozoic terrane accretion and Carboniferous subduction initiation during Gondwanide orogenesis, Permian–Triassic extensional collapse, Jurassic–Paleogene continental arc magmatism, and Neogene flat slab subduction during Andean shortening. The ~550 m.y. record of magmatic activity records spatial trends in magma composition associated with terrane boundaries. East of 69°W, radiogenic isotopic signatures indicate reworked continental lithosphere with enriched (evolved) εHf values and low (&lt;0.65) zircon Th/U ratios during phases of early Paleozoic and Miocene shortening and lithospheric thickening. In contrast, the magmatic record west of 69°W displays depleted (juvenile) εHf values and high (&gt;0.7) zircon Th/U values consistent with increased asthenospheric contributions during lithospheric thinning. Spatial constraints on Mesozoic to Cenozoic arc width provide a rough approximation of relative subduction angle, such that an increase in arc width reflects shallower slab dip. Comparisons among slab dip calculations with time-averaged εHf and Th/U zircon results exhibit a clear trend of decreasing (enriched) magma compositions with increasing arc width and decreasing slab dip. Collectively, these data sets demonstrate the influence of subduction angle on the position of upper-plate magmatism (including inboard arc advance and outboard arc retreat), changes in isotopic signatures, and overall composition of crustal and mantle material along the western edge of South America.
Inferring psychological traits from spending categories and dynamic consumption patterns
Authors: Tovanich Natkamon , Centellegher Simone , Bennacer Seghouani Nacéra , Gladstone Joe , Matz Sandra , Lepri Bruno 
Published: May 2021

AbstractIn recent years there has been a growing interest in analyzing human behavioral data generated by new technologies. One type of digital footprint that is universal across the world, but that has received relatively little attention to date, is spending behavior.In this paper, using the transaction records of 1306 bank customers, we investigated the extent to which individual-level psychological characteristics can be inferred from bank transaction data. Specifically, we developed a more comprehensive feature space using: (1) overall spending behavior (i.e. total number and total amount of transaction), (2) temporal spending behavior (i.e. variability, persistence, and burstiness), (3) category-related spending behavior (i.e. diversity, persistence, and turnover), (4) customer category profile, and (5) socio-demographic information. Using these features, we first explore their association with individual psychological characteristics, we then analyze the performances of the different feature families and finally, we try to understand to what extent psychological characteristics from spending records can be inferred.Our results show that inferring the psychological traits of an individual is a challenging task, even when using a comprehensive set of features that take temporal aspects of spending into account. We found that Materialism and Self-Control could be inferred with relatively high levels of accuracy, while the accuracy obtained for the Big Five traits was lower, with only Extraversion and Neuroticism reaching reasonable classification performances.Hence, for traits like Materialism, Self-control, Extraversion, and Neuroticism our findings could be used to improve psychologically-informed advertising strategies for specific products as well as personality-based spending management apps and credit scoring approaches.