bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of cross-border co-patents: empirical evidence from 45 European regions
Authors: Basche Henrik 
Published: April 2021

AbstractInnovation processes are often interactive because the actors involved require complementary knowledge assets. Given the potentially lower institutional proximity (in terms of language, culture and formal regulations) when compared to domestic counterparts, cross-border interactive innovation processes between actors are less likely to occur. However, these processes are important for firms and (cross-border) regions to ensure economic growth and competitiveness in the long term. In addition, cross-border interactive innovation processes provide opportunities to enhance creative potentials through the combination of knowledge generated in different (national) innovation systems.By simultaneously exploring the effects of institutional proximity, technological proximity, spatial distance and European integration, this paper further enriches the literature. Negative binomial gravity models give insight into the reasons for differences in the number of generated co-patents in 45 European cross-border regions. As expected, spatial and technological distance have negative impacts on co-patent activities in all models. Sharing a common official language (i.e., institutional proximity) significantly increases the number of cross-border co-patents ceteris paribus by a factor of 1.83 to 2.49. Further (qualitative) research is, however, necessary to concretely determine the underlying language effects and to isolate these from cultural factors.Surprisingly, the results also reveal that, ceteris paribus, length of EU membership exerts a significant negative effect on co-patenting, whereas belonging to ‘Central and Eastern European Countries’ has a significant positive effect on co-patenting. Consequently, cross-border regions of the founding EU member states are relatively and ceteris paribus less involved in cross-border co-patenting activities than their Eastern European counterparts.
Rich but not poor conditions determine sex‐specific differences in growth rate of juvenile dioecious plants
Authors: Nowak Kinga , Giertych Marian J. , Pers-Kamczyc Emilia , Thomas Peter A. , Iszkuło Grzegorz 
Published: April 2021

AbstractCauses of secondary sexual dimorphism (SSD) in dioecious plants are very poorly understood, especially in woody plants. SSD is shown mainly in mature plants, but little is known about whether secondary sexual dimorphism can occur in juveniles. It is also assumed that stress conditions intensify differences between the sexes due to the uneven reproductive effort. Therefore, the following research hypotheses were tested: (1) secondary sexual dimorphism will be visible in juveniles; (2) unfavourable soil conditions are the cause of more pronounced differences between the sexes. Rooted shoots of the common yew (Taxus baccata L.) and common juniper (Juniperus communis L.), previously harvested from parental individuals of known sex were used in the study. During two growing seasons vegetation periods and four times a year, comprehensive morphological features of whole plants were measured. Some SSD traits were visible in the analysed juveniles. Contrary to expectations, differences were more pronounced in the fertilized treatment. Both species reacted to fertilization in different ways. Female yew had a clearly higher total plant mass, root mass, and mean root area when fertilized, whereas male juniper had a higher root mass when fertilized. Differences between the sexes independent of the fertilization treatment were seen, which can be interpreted as sexual adaptations to a continued reproduction. Female yews and male junipers made better use of fertile habitats. Our study showed that SSD may be innate, and sexual compensatory mechanisms could generate uneven growth and development of both sexes. Because the SSD pattern was rather different in both species, it was confirmed that SSD is connected with the specific life histories of specific species rather than a universal strategy of dioecious species.
Modelling natural regeneration of European beech in Saxony, Germany: identifying factors influencing the occurrence and density of regeneration
Authors: Axer Maximilian , Martens Sven , Schlicht Robert , Wagner Sven 
Published: April 2021

AbstractThe potential utilisation of natural regeneration of European beech (Fagus sylvatica L.) for forest conversion has received little attention to date. Ecological knowledge is necessary to understand and predict successful natural regeneration of beech. The objective of this study was to improve understanding of what drives the occurrence of beech regeneration and, once regeneration is present, what drives its density. In the study, we utilised a forest inventory dataset provided by Sachsenforst, the state forestry service of Saxony, Germany. The dataset was derived from 8725 permanent plots. Zero-altered negative binomial models (ZANB) with spatial random effects were used to analyse factors influencing occurrence and density simultaneously. The results provided by the spatial ZANB models revealed that the probability of the occurrence of beech regeneration is highly dependent on seed availability, i.e. dependent on source trees in close proximity to a plot. The probability of beech regeneration rises with the increasing diameter of a potential seed tree and decreases with increasing distance to the nearest potential seed source. The occurrence of regeneration is affected by overstorey composition and competition exerted by spruce regeneration. Where sites are affected by groundwater or temporary waterlogging, the impact on the occurrence of regeneration is negative. Although distance to the nearest potential seed source has an influence on occurrence, this variable exerts no influence on density. A high regeneration density arises in conjunction with a high beech basal area in the overstorey. Beech regeneration density, but not occurrence, is negatively affected by browsing intensity. These variables can be used to predict the occurrence and density of beech regeneration in space to a high level of precision. The established statistical tool can be used for decision-making when planning forest conversion using natural regeneration.
Unusually high birch (Betula spp.) pollen concentrations in Poland in 2016 related to long-range transport (LRT) and the regional pollen occurrence
Authors: Myszkowska Dorota , Piotrowicz Katarzyna , Ziemianin Monika , Bastl Maximilian , Berger Uwe , Dahl Åslög , Dąbrowska-Zapart Katarzyna , Górecki Artur , Lafférsová Janka , Majkowska-Wojciechowska Barbara , Malkiewicz Małgorzata , Nowak Małgorzata , Puc Małgorzata , Rybnicek Ondrej , Saarto Annika , Šaulienė Ingrida , Ščevková Jana , Kofol Seliger Andreja , Šikoparija Branko , Piotrowska-Weryszko Krystyna , Czarnobilska Ewa 
Published: April 2021

Abstract
In 2016, the highest birch (Betula spp.) pollen concentrations were recorded in Kraków (Poland) since the beginning of pollen observations in 1991. The aim of this study was to ascertain the reason for this phenomenon, taking the local sources of pollen in Poland and long-range transport (LRT) episodes associated with the pollen influx from other European countries into account. Three periods of higher pollen concentrations in Kraków in 2016 were investigated with the use of pollen data, phenological data, meteorological data and the HYSPLIT numerical model to calculate trajectories up to 4 days back (96 h) at the selected Polish sites. From 5 to 8 April, the birch pollen concentrations increased in Kraków up to 4000 Pollen/m3, although no full flowering of birch trees in the city was observed. The synoptic situation with air masses advection from the South as well as backward trajectories and the general birch pollen occurrence in Europe confirm that pollen was transported mainly from Serbia, Hungary, Austria, the Czech Republic, Slovakia, into Poland. The second analyzed period (13–14 April) was related largely to the local flowering of birches, while the third one in May (6–7 May) mostly resulted from the birch pollen transport from Fennoscandia and the Baltic countries. Unusual high pollen concentrations at the beginning of the pollen season can augment the symptomatic burden of birch pollen allergy sufferers and should be considered during therapy. Such incidents also affect the estimation of pollen seasons timing and severity.

Graphical Abstract
A low-cost chopping system and uncooled microbolometer array for ground-based astronomy
Authors: Rashman M. F. , Steele I. A. , Bates S. D. , Knapen J. H. 
Published: April 2021

AbstractMid-Infrared imaging is vital for the study of a wide variety of astronomical phenomena, including evolved stars, exoplanets, and dust enshrouded processes such as star formation in galaxies. However, infrared detectors have traditionally been expensive and it is difficult to achieve the sensitivity needed to see beyond the overwhelming mid-infrared background. Here we describe the upgrade and commissioning of a simple prototype, low-cost 10 μ m imaging instrument. The system was built using commercially available components including an uncooled microbolometer focal plane array and chopping system. The system was deployed for a week on the 1.52 m Carlos Sanchez Telescope and used to observe several very bright mid-infrared sources with catalogue fluxes down to $\sim 600$
∼
600
Jy. We report a sensitivity improvement of $\sim 4$
∼
4
mag over our previous unchopped observations, in line with our earlier predictions.
Threshold selection in univariate extreme value analysis
Authors: Schneider Laura Fee , Krajina Andrea , Krivobokova Tatyana 
Published: April 2021

AbstractThreshold selection plays a key role in various aspects of statistical inference of rare events. In this work, two new threshold selection methods are introduced. The first approach measures the fit of the exponential approximation above a threshold and achieves good performance in small samples. The second method smoothly estimates the asymptotic mean squared error of the Hill estimator and performs consistently well over a wide range of processes. Both methods are analyzed theoretically, compared to existing procedures in an extensive simulation study and applied to a dataset of financial losses, where the underlying extreme value index is assumed to vary over time.
Current recommendations for cancer surveillance in Gorlin syndrome: a report from the SIOPE host genome working group (SIOPE HGWG)
Authors: Guerrini-Rousseau L. , Smith M. J. , Kratz C. P. , Doergeloh B. , Hirsch S. , Hopman S. M. J. , Jorgensen M. , Kuhlen M. , Michaeli O. , Milde T. , Ridola V. , Russo A. , Salvador H. , Waespe N. , Claret B. , Brugieres L. , Evans D. G. 
Published: April 2021

AbstractGorlin syndrome (MIM 109,400), a cancer predisposition syndrome related to a constitutional pathogenic variation (PV) of a gene in the Sonic Hedgehog pathway (PTCH1 or SUFU), is associated with a broad spectrum of benign and malignant tumors. Basal cell carcinomas (BCC), odontogenic keratocysts and medulloblastomas are the main tumor types encountered, but meningiomas, ovarian or cardiac fibromas and sarcomas have also been described. The clinical features and tumor risks are different depending on the causative gene. Due to the rarity of this condition, there is little data on phenotype-genotype correlations. This report summarizes genotype-based recommendations for screening patients with PTCH1 and SUFU-related Gorlin syndrome, discussed during a workshop of the Host Genome Working Group of the European branch of the International Society of Pediatric Oncology (SIOPE HGWG) held in January 2020. In order to allow early detection of BCC, dermatologic examination should start at age 10 in PTCH1, and at age 20 in SUFU PV carriers. Odontogenic keratocyst screening, based on odontologic examination, should begin at age 2 with annual orthopantogram beginning around age 8 for PTCH1 PV carriers only. For medulloblastomas, repeated brain MRI from birth to 5 years should be proposed for SUFU PV carriers only. Brain MRI for meningiomas and pelvic ultrasound for ovarian fibromas should be offered to both PTCH1 and SUFU PV carriers. Follow-up of patients treated with radiotherapy should be prolonged and thorough because of the risk of secondary malignancies. Prospective evaluation of evidence of the effectiveness of these surveillance recommendations is required.
Basin-Scale 3D Sedimentary Modelling: An Approach to Subdivide Baltic Sea Onshore Sediments for Land use and Construction
Authors: Ojala Antti E. K. , Virtasalo Joonas J. , Lindsberg Elina , Markovaara-Koivisto Mira 
Published: April 2021

AbstractUnderstanding the local stratigraphy and geometry of sediment units is necessary for successful 3D modelling and the prediction of ground behaviour and engineering-geological properties for urban land use and construction. A detailed 3D model of the main sediment units for the Rastaala basin in southern coastal Finland was constructed, combining a conceptual geological model and information from local drill-hole logs and geotechnical drilling. The 3D modelling was based on a cross-section approach, where sediment units were defined on the basis of lithological boundaries that are of major geotechnical importance for land use and construction. The conceptual geological model was based on a sequence of events that characterize the late- and postglacial evolution of the Rastaala basin. The present study combines the allostratigraphy and lithostratigraphy of unconsolidated glacial, late-and postglacial sediment units in southern coastal Finland. It also investigates the appearance and distribution of sediment units in the Rastaala basin and compares modelling and visualization results for unit surfaces and solids using two independent modelling software packages. Finally, information on the geotechnical properties of different sediment units in the Rastaala basin is provided so that they can be applied to other onshore regions with similar geological settings in the coastal Baltic Sea Basin.
Review of Relationships Between Solar Wind and Ground-Level Atmospheric Electricity: Case Studies from Hornsund, Spitsbergen, and Swider, Poland
Authors: Michnowski S. , Odzimek A. , Kleimenova N. G. , Kozyreva O. V. , Kubicki M. , Klos Z. , Israelsson S. , Nikiforova N. N. 
Published: April 2021

AbstractThis paper reviews individual cases of the relationships between variations of solar wind parameters and variations of the DC vertical atmospheric electric field, $$E_z$$

E
z

, and current density, $$J_z$$

J
z

, measured at ground level in the Arctic, at the S. Siedlecki Polish Polar Station Hornsund, Spitsbergen (Svalbard, Norway), and at the mid-latitude S. Kalinowski Geophysical Observatory in Swider (Poland). A considerable number of events from Hornsund confirmed previous observations of regularity of effects related to the station’s position against the location of the potential bays of ionospheric convection and polar electrojets, observed in other polar locations, as well as effects of other polar cap current systems. This allowed us to conclude that the physical dependence of ground-level $$E_z$$

E
z

and $$J_z$$

J
z

on solar wind changes produce measurable effects which do not require statistical analysis to be observed. We can also expect that the dependence does exist, especially in strongly disturbed circumstances, e.g., following solar flares and Earth-directed coronal mass ejections, at middle latitudes. However, further investigations of these physical relationships by this approach are practically almost impossible since a very large number of variable parameters simultaneously affect the recorded lower atmospheric variables. In addition, results of quantitative analysis of predicted and observed effects are not satisfactory. Future research studies require more efficient ways of investigation by theoretical treatment and modelling work using existing and novel observational data besides taking advantage of scientific progress in magnetospheric physics.
Effect of carbon backbone on luminescence properties of Eu-organic hybrid thin films prepared by ALD/MLD
Authors: Safdar Muhammad , Ghazy Amr , Tuomisto Minnea , Lastusaari Mika , Karppinen Maarit 
Published: April 2021

AbstractHere we show that the backbone of the organic ligand has a profound impact on the luminescence characteristics of lanthanide-organic materials. We employ the emerging atomic/molecular layer deposition (ALD/MLD) technique to deposit europium-based thin films where the organic ligands vary in terms of the number of aromatic rings in their backbone (benzene, naphthalene and anthracene). Enlarging the backbone shifts the excitation towards visible wavelengths, but it simultaneously decreases the emission intensity. Moreover, for the Eu-terephthalate films with the single benzene ring as the organic backbone, we investigate the effects of diluting the Eu3+ concentration with Y3+ to reveal that the emission intensity is optimized around 12% Eu3+ concentration. Interestingly, such a dependence of luminescence intensity on the concentration of emitting species suggests that our (Eu,Y)-organic thin films behave more like ionic phosphors than discrete metal–ligand molecules.
Graphical abstract
Genetic Mosaicism as a Cause of Inborn Errors of Immunity
Authors: Aluri Jahnavi , Cooper Megan A. 
Published: April 2021

AbstractInborn errors of immunity (IEIs) are a heterogeneous group of disorders due to genetic defects in the immune response that have a broad clinical spectrum. Diagnosis of the precise genetic cause of IEI has led to improved care and treatment of patients; however, genetic diagnosis using standard approaches is only successful in ~40% of patients and is particularly challenging in “sporadic” cases without a family history. Standard genetic testing for IEI evaluates for germline changes in genes encoding proteins important for the immune response. It is now clear that IEI can also arise from de novo mutations leading to genetic variants present in germ cells and/or somatic cells. In particular, somatic mosaicism, i.e., post-zygotic genetic changes in DNA sequence, is emerging as a significant contributor to IEI. Testing for somatic mosaicism can be challenging, and both older sequencing techniques such as Sanger sequencing and newer next-generation sequencing may not be sensitive enough to detect variants depending on the platform and analysis tools used. Investigation of multiple tissue samples and specifically targeting sequence technologies to detect low frequency variants is important for detection of variants. This review examines the role and functional consequences of genetic mosaicism in IEI. We emphasize the need to refine the current exome and genome analysis pipeline to efficiently identify mosaic variants and recommend considering somatic mosaicism in disease discovery and in the first-tier of genetic analysis.
Limited Impact of 6-Mercaptopurine on Inflammation-Induced Chemokines Expression Profile in Primary Cultures of Enteric Nervous System
Authors: Kneusels Jan , Kaehler Meike , Cascorbi Ingolf , Wedel Thilo , Neunlist Michel , Lucius Ralph , Cossais François 
Published: April 2021

AbstractIncreasing evidences indicate that the enteric nervous system (ENS) and enteric glial cells (EGC) play important regulatory roles in intestinal inflammation. Mercaptopurine (6-MP) is a cytostatic compound clinically used for the treatment of inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease. However, potential impacts of 6-MP on ENS response to inflammation have not been evaluated yet. In this study, we aimed to gain deeper insights into the profile of inflammatory mediators expressed by the ENS and on the potential anti-inflammatory impact of 6-MP in this context. Genome-wide expression analyses were performed on ENS primary cultures exposed to lipopolysaccharide (LPS) and 6-MP alone or in combination. Differential expression of main hits was validated by quantitative real-time PCR (qPCR) using a cell line for EGC. ENS cells expressed a broad spectrum of cytokines and chemokines of the C-X-C motif ligand (CXCL) family under inflammatory stress. Induction of Cxcl5 and Cxcl10 by inflammatory stimuli was confirmed in EGC. Inflammation-induced protein secretion of TNF-α and Cxcl5 was partly inhibited by 6-MP in ENS primary cultures but not in EGC. Further work is required to identify the cellular mechanisms involved in this regulation. These findings extend our knowledge of the anti-inflammatory properties of 6-MP related to the ENS and in particular of the EGC-response to inflammatory stimuli.
Correcting the Underestimation of Capital Incomes in Inequality Indicators: with an Application to the UK, 1997–2016
Authors: Ooms Tahnee Christelle 
Published: April 2021

AbstractThis paper proposes a methodological framework to better incorporate non-labour income into existing top adjusted indicators of economic inequality. Surveys are known to miss the rich, receiving disproportionate amounts of capital income. There has been a surge in top harmonisation methodologies, which complement survey-based estimates of inequality with information from the rich reported in tax administrative sources. These harmonisation methods are found to have a significant upward effect on inequality indicators. This analysis uses the Family Resources Survey (household survey) and the Survey of Personal Incomes (tax data) to explore the extent to which existing UK harmonisation methodology corrects for capital income. First, this analysis finds that the FRS has experienced a significant decline in capital income measurement over the past 20 years (1997–2016), taking reported levels of capital income in the SPI as benchmark. Second, the top harmonisation methodology is found to only partially correct for this decline. Third, in response, the paper proposes a multi-step capital income correction to allocate the remaining capital income missing from top adjusted inequality indicators. The adjustment accounts for both under-coverage and under-estimation error of capital income across the income distribution. Poor measurement of capital incomes in household surveys has long been acknowledged but attempts to correct for this have remained few. This paper highlights the need for decomposable top adjusted indicators of inequality to give a better picture of the role of capital incomes in driving inequality. Surveys are traditionally used to produce inequality indicators used by governments, statistical offices and policy makers. The policy implication is that income missing from indicators structurally falls out of inequality debates, which has arguably been the case for capital incomes.