bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Ability of the English Literature Department Students in English Poetry Reading Skill
Authors: Hudriati Andi , Sain Najihuddin 
Published: January 2021

The objectives of this study are: (1) To know students’ ability in reading English Poetry. (2) To know the difficulties that the student find in reading English Poetry. The data was analyzed by using a quantitative descriptive method. The study data was collected by using some research instruments, such as reading test and interview. The data were tabulated into students’ average scores in five indicators and mean scores. Then, the authors explained the data descriptively. Based on the data findings, the students’ ability to read English Poetry was qualified as “poor”. This was indicated by the score in each part of the students were low, especially in facial expression and body language. Through this study, the authors aimed to help the student to learn how to read English Poetry, and the students hoped to increase their ability to read English Poetry.
A felsőoktatás digitális oktatási kultúrájának korrajza szakértői interjúk alapján
Authors: Hülber László , Papp-Danka Adrienn , Dringó-Horváth Ida 
Published: January 2021

Az IKT eszközök a paradigmaváltás ígéretét sugallják a nevelés területén is, de komplex kihívást teremtenek azáltal, hogy nemcsak az oktatás folyamatát támogatják, hanem annak tárgyává is váltak. A technológia oktatásba való integrációja nem az elvárt eredményességgel valósul meg, kényszerítő hatású érvényesülése sokszor rossz módszertani gyakorlatot eredményez. Kutatásunkban az ország 24 elismert oktatásinformatikai, felsőoktatáspedagógiai szakértőjével készítettünk interjút azzal a céllal, hogy a felsőoktatás digitális oktatási kultúrájának jelenlegi helyzetét bemutassuk, egyfajta korlenyomatot biztosítva. Az interjúkérdések a módszertan, az önfejlesztés és a digitális oktatási kultúra értékelése tématerületek köré szerveződtek. A kapott válaszokat kvalitatív módszerrel dolgoztuk fel és a leírt szövegeket a tartalomelemzés szabályai szerint kódoltuk. Az eredmények bemutatása során a szakértői véleményeket szintetizáltuk, mert így kívánjuk segíteni a felsőoktatásban dolgozók módszertani kultúrájának formálását, tévképzeteik eloszlatását a pandémia által bevezetett kötelező digitális oktatás kihívásokkal teli időszakában.While ICT tools are promising a paradigm shift in education, they are also presenting a complex challenge by being not only an aid to the process of education but also the subject of it. The integration of technology into education has not been bringing the expected success, and when implemented by force, they often result in poor methodological practice. In our study, we interviewed 24 renowned experts in educational informatics and higher education pedagogy in Hungary in order to acquire and present a picture of the current state of digital educational culture in higher education. The interview questions are centered around the topics of methodology, self-improvement, and the evaluation of digital educational culture. Responses were processed qualitatively and transcripts were coded according to the standard rules of content analysis. In the discussion of the results, answers were synthesized, because our aim is to shape the methodological culture of teachers in higher education and to dispel their misconceptions in this challenging period of compulsory digital education forced upon them by the pandemic.
Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
Authors: Zheng Dandan , Zhu Yu , Shen Yili , Xiao Sisi , Yang Lehe , Xiang Youqun , Dai Xuanxuan , Hu Wanle , Zhou Bin , Liu Zhiguo , Zhao Haiyang , Zhao Chengguang , Huang Xiaoying , Wang Liangxing 
Published: January 2021

BackgroundColorectal cancer (CRC) is the second deadliest malignant disease in the world and the leukemia inhibitory factor receptor/signal transducers and activators of transcriptions (LIFR/STATs) signaling axis plays an important role in the molecular biology of CRC.MethodsCell function tests were performed to observe the inhibitory effect of cynaropicrin on human CRC cells (RKO, HCT116, and DLD-1). Expression levels of LIFR, P-STAT3, P-STAT4, and apoptotic proteins were detected by Western blotting. Immunoprecipitation confirmed the presence of LIFR/STAT3/STAT4 complex. Cell immunofluorescence assay was used to observe the subcellular localization of STAT3 and STAT4. In vivo efficacy of cynaropicrin was evaluated by a xenotransplantation model in nude mice.ResultsCynaropicrin significantly reduced the survival ability of human CRC cells and promoted apoptosis in a dose-dependent manner. Western blotting results suggested that the antitumor effects of cynaropicrin might be mediated by inhibition of the LIFR/STATs axis. Cynaropicrin reduced the formation of STAT3/STAT4 heterodimers and blocked their entry into the nucleus. Cynaropicrin also suppressed tumor growth in the xenograft model.ConclusionThe results showed that cynaropicrin exerted a strong inhibitory effect on CRC in vitro and in vivo. Our study concluded that cynaropicrin has potential application prospects in the field of anti-CRC therapy.
Frequent Pet Contact as Risk Factor for Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis
Authors: Grehn Claudia , Eschenhagen Patience , Temming Svenja , Düesberg Uta , Neumann Konrad , Schwarz Carsten 
Published: January 2021

Aspergillus fumigatus (Af) frequently colonizes the respiratory tract of patients with cystic fibrosis (CF). Af is associated with loss of pulmonary function and allergic bronchopulmonary aspergillosis (ABPA), a hypersensitivity fungal lung disease. Environmental factors have impact on CF patients’ lung function variation. The aim of this nationwide questionnaire survey was to investigate the amount of CF patients with frequent pet contact including pet species and to examine the potential impact of frequent pet contact on the occurrence of Af colonization and ABPA diagnosis in these patients. The survey was carried out in 31 German CF centers in 2018. A total of 1232 who completed the surveys were included, and statistical analysis was performed by chi-squared test. Within the study cohort 49.8% of subjects (n = 614; CF patients &lt; 18years: 49.4%, n = 234; ≥ 18years: 50.1%, n = 380) reported frequent contact to pets, of which 60.7% reported frequent contact to dogs, 42.3% to cats and other animals. Of those with frequent pet contact, 71.8% (n = 441) had contact to one pet or more pets from the same family. Af colonization was not significantly associated with frequent pet contact. ABPA diagnosis was documented in 16.7% (n = 206) of all included CF patients and was significantly associated with frequent pet contact (18.9%, n = 116, p = 0.042), confirming previous single center examinations. Particularly, patients with frequent contact to dogs showed an increased ABPA prevalence of 21.3%. Frequent pet contact might be a risk factor for ABPA. CF patients who are sensitized to Af should be informed about the increased risk to develop an ABPA by frequent pet contact. Patients with recurrent onset of ABPA should be evaluated in terms of frequent pet contact.
Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification
Authors: Huang Lili , Chen Xin , Sun Wenshan , Chen Haifeng , Ye Qing , Yang Dan , Li Mengchun , Luo Caimei , Ma Junyi , Shao Pengfei , Xu Hengheng , Zhang Bing , Zhu Xiaolei , Xu Yun 
Published: January 2021

Objective: To characterize earlier damage pattern of white matter (WM) microstructure in cerebral small vessel disease (CSVD) and its relationship with cognitive domain dysfunction.Methods: A total of 144 CSVD patients and 100 healthy controls who underwent neuropsychological measurements and diffusion tensor imaging (DTI) examination were recruited. Cognitive function, emotion, and gait were assessed in each participant. The automated fiber quantification (AFQ) technique was used to extract different fiber properties between groups, and partial correlation and general linear regression analyses were performed to assess the relationship between position-specific WM microstructure and cognitive function.Results: Specific segments in the association fibers, commissural WM regions of interest (ROIs), and projection fibers were damaged in the CSVD group [P &lt; 0.05, family-wise error (FWE) correction], and these damaged segments showed interhemispheric symmetry. In addition, the damage to specific tract profiles [including the posteromedial component of the right cingulum cingulate (CC), the occipital lobe portion of the callosum forceps major, the posterior portion of the left superior longitudinal fasciculus (SLF), and the bilateral anterior thalamic radiation (ATR)] was related to the dysfunction in specific cognitive domains. Among these tracts, we found the ATR to be the key set of tracts whose profiles were most associated with cognitive dysfunction. The left ATR was a specific fiber bundle associated with episode memory and language function, whereas the fractional anisotropy (FA) values of the intermediate component of the right ATR were negatively correlated with executive function and gait evaluation. It should be noted that the abovementioned relationships could not survive the Bonferroni correction (p &lt; 0.05/27), so we chose more liberal uncorrected statistical thresholds.Conclusions: Damage to the WM fiber bundles showed extensive interhemispheric symmetry and was limited to particular segments in CSVD patients. Disruption of strategically located fibers was associated with different cognitive deficits, especially the bilateral ATR.
The Use of Vitamin K2 in Patients With Parkinson's Disease and Mitochondrial Dysfunction (PD-K2): A Theranostic Pilot Study in a Placebo-Controlled Parallel Group Design
Authors: Prasuhn Jannik , Kasten Meike , Vos Melissa , König Inke R. , Schmid Sebastian M. , Wilms Britta , Klein Christine , Brüggemann Norbert 
Published: January 2021

Background: Despite rapid advances in research on Parkinson's disease (PD), in particular in the elucidation of genetic contributions, no disease-modifying therapy has become available to date.Objectives: In the proposed project, we aim to investigate the potential effects of vitamin K2 (long-chain menaquinone 7, MK-7) in genetically determined PD with mitochondrial dysfunction.Methods: A total of 130 study participants (26 biallelic Parkin/PINK1 mutation carriers, 52 sporadic PD patients, and 52 healthy controls) will receive the trial medication (MK-7 or placebo for 1 week). 31P-Magnetic resonance spectroscopy imaging of the forebrain and basal ganglia (31P-MRSI, primary endpoint) as well as other advanced neuroimaging methods, clinical assessment, including quantitative movement analysis, and biomarker sampling will be applied pre- and post-intervention.Innovation: The proposed project is highly translational as it builds on compelling mechanistic data from animal studies as well as on a small preliminary data set in humans. Patients are selected based on their mutation-related mitochondrial dysfunction and compared to disease and a healthy control group in a personalized medicine approach. We will further investigate how neuroimaging and blood-derived biomarkers can predict individual treatment response in sporadic PD.Clinical trial registration: This study was registered at the German Clinical Trial Registry (DRKS, DRKS00019932) on the 19th of December 2019.
The Role of Body Image on Psychosocial Outcomes in People With Diabetes and People With an Amputation
Authors: McDonald Sarah , Sharpe Louise , MacCann Carolyn , Blaszczynski Alex 
Published: January 2021

IntroductionResearch indicates that body image disturbance is associated with poorer psychosocial outcomes for individuals with physical health conditions, with poorest body image reported for individuals with visible bodily changes. Using White’s (2000) theoretical model of body image the present paper aimed to examine the nature of these relationships in two distinct groups: individuals with an amputation and individuals with diabetes. It was hypothesized that body image disturbance would be associated with psychosocial outcomes and would mediate the relationships between self-ideal discrepancy and personal investment in psychosocial outcomes.MethodsIndividuals with diabetes (N = 212) and individuals with an amputation (N = 227) provided details regarding their medical condition, and completed measures assessing body image, investment, self-ideal discrepancy, depression, anxiety, and quality of life. Structural equation and invariance modeling were used to test the model paths and the invariance of the model.ResultsAs hypothesized, body image disturbance was found to mediate the relationships between personal investment and psychosocial outcome, and between self-ideal discrepancy and psychosocial outcome. The predicted paths were invariant across groups, although the model accounted for more variance in people with an amputation than people with diabetes.ConclusionBody image disturbance, personal investment, and self-ideal discrepancy are important factors contributing to psychosocial outcome for individuals with diabetes and individuals with an amputation. These findings not only confirm the validity of the model in these two groups, but they emphasize the importance of targeting body image in future psychological interventions for individuals with a health condition.
Tackling Energy Poverty Through Behavioral Change: A Pilot Study on Social Comparison Interventions in Social Housing Districts
Authors: Caballero Nicolas , Della Valle Nives 
Published: January 2021

Behavioral Economics has in recent years played a key role in informing the design of non-price interventions aimed at promoting energy conservation behaviors in residential housing. Some of the most influential contributions of the discipline in an applied setting have centered around the development of norm-based interventions. The success that these interventions have had in specific contexts presents an opportunity to exploit them as tools for tackling a prevalent type of poverty at the EU level: energy poverty. Recent contributions to the literature highlight the role of inefficient energy behavior as a significant driver of this particular type of poverty, which is characterized by an inability to afford the basic energy services necessary to guarantee a decent standard of living. Therefore, the effectiveness of norm-based interventions in vulnerable populations merits further investigation to determine whether this approach can suitably address the behavioral components of energy poverty by promoting efficient energy consumption and conservation efforts. This study reports on a pilot conducted in an exemplary social housing context (located in Bolzano, Italy) with the aim to assess the effectiveness of social comparison interventions in energy vulnerable groups. Our investigated cohort covers an initial small sample of apartments with a large representatives of elderly individuals and other energy-vulnerable groups. Using a design that combines appeals to injunctive and descriptive norms embedded within In-Home Devices (IHD) in recently retrofitted homes, our objective is to set a basis for the assessment of effectiveness of these types of interventions in social housing populations. Our study seeks to provide useful methodological insights to policy makers on how to effectively design behaviorally informed interventions aimed at tackling energy poverty. Despite the current data limitations, our results do seem to suggest that uniformly applied norm-based interventions may have potentially backfiring effects in small-scale implementations. Therefore, they suggest that attention needs to be paid to household composition and pre-existing levels of consumption, when designing behavior-change interventions in these groups.JEL Classification: C93; D03; D04; D12; D19; D91; Q40.
Liderazgo transformacional y transaccional en la autoeficacia emprendedora del turismo comunitario amazónico, caso provincia de Pastaza
Authors: Manosalvas Vaca Luis Oswaldo , Tobanda Barragán Angélica Aracely , Manosalvas Vaca Carlos Aníbal , Quevedo Amay Deisy Valeria 
Published: January 2021

La presente investigación tiene como objetivo analizar la relación del Liderazgo transformacional y transaccional con la Autoeficacia emprendedora en una comunidad indígena ubicada en Amazonía ecuatoriana, Provincia de Pastaza, donde se desarrolló una evaluación de las características demográficas de la muestra y un análisis descriptivo de las variables de estudio, para analizar la variable liderazgo se utilizó el cuestionario multifactorial de liderazgo (Multifactor Leadership Questionnaire (MLQ), y el instrumento de autoeficacia emprendedora desarrollado por De Noble et al. (1999). Además, se midió la confiabilidad de los instrumentos con un análisis de Cronbach y mediante la correlación de Pearson se determinó que el liderazgo transformacional se relaciona de manera significativa con la autoeficacia emprendedora, sin embargo, el liderazgo transaccional no se relaciona con la autoeficacia emprendedora; los resultados indicaron que la actividad emprendedora de la comunidad tiene una influencia de carácter transformacional a través de sus emprendedores líderes, quienes apoyan el desarrollo emprendedor considerando el avance personal de los miembros, sin embargo, no se ha identificado una relación de un proceso de transacción o recompensa en las actividades de emprendimiento, esto permite generar posibles investigaciones que analicen futuros comportamientos de emprendimiento con respecto a procedimientos transaccionales y transformacionales de liderazgo en el emprendimientos en diversos contextos similares.
A Comparison Study of Coronavirus Disease 2019 Outcomes in Hospitalized Kidney Transplant Recipients
Authors: Mansour Sherry G. , Malhotra Divyanshu , Simonov Michael , Yamamoto Yu , Arora Tanima , Subair Labeebah , Alausa Jameel , Moledina Dennis G. , Greenberg Jason H. , Wilson Francis Perry , Marin Ethan P. 
Published: January 2021

Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect any human host, but kidney transplant recipients (KTR) are considered more susceptible on the basis of previous experience with other viral infections. We evaluated rates of hospital complications between SARS-CoV-2–positive KTR and comparator groups.

Methods
We extracted data from the electronic health record on patients who were hospitalized with SARS-CoV-2, testing at six hospitals from March 4 through September 9, 2020. We compared outcomes between SARS-CoV-2–positive KTR and controls: SARS-CoV-2–positive non-KTR, SARS-CoV-2–negative KTR, and SARS-CoV-2–negative non-KTR.

Results
Of 31,540 inpatients, 3213 tested positive for SARS-CoV-2. There were 32 SARS-CoV-2–positive and 224 SARS-CoV-2–negative KTR. SARS-CoV-2–positive KTR had higher ferritin levels (1412; interquartile range, 748–1749 versus 553; interquartile range, 256–1035; P<0.01) compared with SARS-CoV-2–positive non-KTR. SARS-CoV-2–positive KTR had higher rates of ventilation (34% versus 14%, P<0.01; versus 9%, P<0.01; versus 5%, P<0.01), vasopressor use (41% versus 16%, P<0.01; versus 17%, P<0.01; versus 12%, P<0.01), and AKI (47% versus 15%, P<0.01; versus 23%, P<0.01; versus 10%, P<0.01) compared with SARS-CoV-2–positive non-KTR, SARS-CoV-2–negative KTR, and SARS-CoV-2–negative non-KTR, respectively. SARS-CoV-2–positive KTR continued to have increased odds of ventilation, vasopressor use, and AKI compared with SARS-CoV-2–positive non-KTR independent of Elixhauser score, Black race, and baseline eGFR. Mortality was not significantly different between SARS-CoV-2–positive KTR and non-KTR, but there was a notable trend toward higher mortality in SARS-CoV-2–positive KTR (25% versus 16%, P=0.15, respectively).

Conclusions
Hospitalized SARS-CoV-2–positive KTR had a high rate of mortality and hospital complications, such as requiring ventilation, vasopressor use, and AKI. Additionally, they had higher odds of hospital complications compared with SARS-CoV-2–positive non-KTR after adjusting for Elixhauser score, Black race, and baseline eGFR. Future studies with larger sample size of KTR are needed to validate our findings.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/K360/2021_03_25_KID0005652020.mp3
Longitudinal Changes in the Use of PD Assistance for Patients Maintained on Peritoneal Dialysis
Authors: Fonseca-Correa Jorge I. , Farragher Janine F. , Tomlinson George , Oliver Matthew J. , Jain Arsh , Flanagan Susan , Koyle Kathleen , Jassal Sarbjit V. 
Published: January 2021

Background
Home dialysis therapies, such as peritoneal dialysis (PD), offer flexibility and improved well-being, particularly for older individuals. However, a substantial proportion require assistance with personal care and health care–related tasks. We hypothesized that patients and families would require less PD assistance as they became more familiar with PD-related tasks. The study objective was to assess whether the nature of, and need for, PD assistance decreased over time.

Methods
Using a multicentered, prospective, observational study design, patients aged ≥50 years were recruited from those starting PD. Patients underwent formal evaluation using validated components of a Comprehensive Geriatric Assessment at baseline, and they were followed monthly and administered a questionnaire about the need for assistance with PD-related tasks.

Results
A total of 111 patients (age 69±10 years, 68% men, and 56% diabetic) were followed for a total of 609 patient-months. Of those who needed help, 40% had help from a family member, and 33% were helped by nurses. Both the quantity and nature of help received by patients remained generally stable throughout follow-up and did not vary according to age, frailty, functional dependence, or cognitive impairment (P=0.93). The proportion of patients needing help varied widely across the 13 different tasks but appeared relatively stable across time. The paid-unpaid caregiver ratio for the different tasks did not change over time.

Conclusions
Older patients initiating PD in the outpatient setting have a high need for assistance with PD-related tasks, which seems to persist over the initial 6-month period.
Análisis del Mercado de las Aerolíneas Tradicionales y Low Cost en Ecuador
Authors: Zambrano Verdesoto German Jazmany 
Published: January 2021

El desarrollo constante que tienen las aerolíneas en Ecuador es importante para incrementar la economía del país, siendo este factor principal para que los clientes tengan una ventaja significativa al momento de comprar un pasaje, esta investigación pretende realizar un estudio de las principales funciones que tiene en el mercado las aerolíneas tradicionales y low cost en Ecuador. El objetivo fundamental es realizar un análisis comparativo de precios y los servicios y cómo se ha desarrollado en el mercado local las aerolíneas tradicionales y low cost. El estudio que se aplicó es de análisis bibliográfico y de las fuentes información que se utilizan para el análisis de precios y servicios son los sitios web que tienen las aerolíneas.