bluuebunny/crossref_metadata_2025_split huggingface dataset:
STATUS OF THE PARODONTIUM TISSUES IN THE CONDITIONS OF LONG-TERM ISOLATION INSIDE AN AIR-TIGHT MODULE
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Ilyin V.K. , Rykova M.P. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Antropova E.N. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Solovieva Z.O. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Skedina M.A. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Kovaleva А.А. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Nosovsky А.М. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: November 2021

The comprehensive investigation of parodontium tissues of the participants in a 120-d isolation study imitating the artificial spacecraft environment was focused on anaerobic microbiota, immunological parameters of the oral liquid and blood flow velocity within the parodentium microcirculation (PMC).	Subjects were 6 healthy people (3 males and 3 females) at the age of 29 to 45 years. Parodentium tissues were investigated 14 and 1 day prior to isolation, 3 times in isolation (every 30 days) and on days 1 and 7 after isolation. Qualitative composition of primary pathogens was determined by the polymerase chain reaction (PCR). Concentration of oral immunoglobulins sIgA, IgA, IgМ was measured using the ELISA assay. Blood flow velocity was measured using high-frequency ultrasound Doppler. Our results showed an increase in the immunoglobulins on days 30 and 84 of isolation and subsequent reduction toward the end of the study. The participants were found to be careers of type-1 pathogen Porphyromonas gingivalis and type-2 pathogen Prevotella intermedia. Following isolation, linear indices of the arteriolar blood velocity grew reliably (p < 0.0007); the capillary blood velocity grew by 6.7 % relative to the pre-isolation baseline data. On day 7, capillary perfusion was noted to improve still further. The observed shifts in the local immunity and presence of pathogens point to deterioration of the parodontium defense mechanisms. It appears that activation of inflammatory processes in isolation and confinement remains probable.
The Impact of Artificial Intelligence on Waiting Time for Medical Care in an Urgent Care Service for COVID-19: Single-Center Prospective Study
Authors: Bin Kaio Jia , Melo Adler Araujo Ribeiro , da Rocha José Guilherme Moraes Franco , de Almeida Renata Pivi , Cobello Junior Vilson , Maia Fernando Liebhart , de Faria Elizabeth , Pereira Antonio José , Battistella Linamara Rizzo , Ono Suzane Kioko 
Published: November 2021

Background
To demonstrate the value of implementation of an artificial intelligence solution in health care service, a winning project of the Massachusetts Institute of Technology Hacking Medicine Brazil competition was implemented in an urgent care service for health care professionals at Hospital das Clínicas of the Faculdade de Medicina da Universidade de São Paulo during the COVID-19 pandemic.

Objective
The aim of this study was to determine the impact of implementation of the digital solution in the urgent care service, assessing the reduction of nonvalue-added activities and its effect on the nurses’ time required for screening and the waiting time for patients to receive medical care.

Methods
This was a single-center, comparative, prospective study designed according to the Public Health England guide “Evaluating Digital Products for Health.” A total of 38,042 visits were analyzed over 18 months to determine the impact of implementing the digital solution. Medical care registration, health screening, and waiting time for medical care were compared before and after implementation of the digital solution.

Results
The digital solution automated 92% of medical care registrations. The time for health screening increased by approximately 16% during the implementation and in the first 3 months after the implementation. The waiting time for medical care after automation with the digital solution was reduced by approximately 12 minutes compared with that required for visits without automation. The total time savings in the 12 months after implementation was estimated to be 2508 hours.

Conclusions
The digital solution was able to reduce nonvalue-added activities, without a substantial impact on health screening, and further saved waiting time for medical care in an urgent care service in Brazil during the COVID-19 pandemic.
Introduction of Systematized Nomenclature of Medicine–Clinical Terms Coding Into an Electronic Health Record and Evaluation of its Impact: Qualitative and Quantitative Study
Authors: Pankhurst Tanya , Evison Felicity , Atia Jolene , Gallier Suzy , Coleman Jamie , Ball Simon , McKee Deborah , Ryan Steven , Black Ruth 
Published: November 2021

Background
This study describes the conversion within an existing electronic health record (EHR) from the International Classification of Diseases, Tenth Revision coding system to the SNOMED-CT (Systematized Nomenclature of Medicine–Clinical Terms) for the collection of patient histories and diagnoses. The setting is a large acute hospital that is designing and building its own EHR. Well-designed EHRs create opportunities for continuous data collection, which can be used in clinical decision support rules to drive patient safety. Collected data can be exchanged across health care systems to support patients in all health care settings. Data can be used for research to prevent diseases and protect future populations.

Objective
The aim of this study was to migrate a current EHR, with all relevant patient data, to the SNOMED-CT coding system to optimize clinical use and clinical decision support, facilitate data sharing across organizational boundaries for national programs, and enable remodeling of medical pathways.

Methods
The study used qualitative and quantitative data to understand the successes and gaps in the project, clinician attitudes toward the new tool, and the future use of the tool.

Results
The new coding system (tool) was well received and immediately widely used in all specialties. This resulted in increased, accurate, and clinically relevant data collection. Clinicians appreciated the increased depth and detail of the new coding, welcomed the potential for both data sharing and research, and provided extensive feedback for further development.

Conclusions
Successful implementation of the new system aligned the University Hospitals Birmingham NHS Foundation Trust with national strategy and can be used as a blueprint for similar projects in other health care settings.
Developing Graphic Messages for Vaping Prevention Among Black and Latino Adolescents: Participatory Research Approach
Authors: Cartujano-Barrera Francisco , Azogini Chiamaka , McIntosh Scott , Bansal-Travers Maansi , Ossip Deborah J , Cupertino Ana Paula 
Published: November 2021

Background
As an important transition stage in human development, adolescence is a critical window for vaping prevention. There is a substantial gap in communication research on vaping prevention among racial and ethnic minority groups. Their representation is essential to develop, implement, and disseminate innovative and effective interventions for vaping prevention.

Objective
The aim of this study is to describe the participatory research (PR) procedures used with Black and Latino adolescents to develop culturally and linguistically appropriate graphic messages for vaping prevention.

Methods
This PR study used a qualitative, user-centered design method. We conducted a series of focus groups with 16 Black and Latino adolescents to develop culturally and linguistically appropriate graphic messages for vaping prevention. The biobehavioral model of nicotine addiction provided a framework for the development of the graphic messages. Participants met 4 times to provide iterative feedback on the graphic messages until they reached a consensus on overall quality and content.

Results
At baseline, the participants’ mean age was 15.4 years (SD 1.4). Of the participants, 50% (8/16) were female, 88% (14/16) were heterosexual, 56% (9/16) were Black/African American, and 44% (7/16) were Hispanic/Latino. A total of 12 of the 16 participants (75%) chose to participate in the English sessions. Participants decided to create four types of graphic messages: (1) financial reward, (2) health reward, (3) social norms, and (4) self-efficacy. Meeting 4 times with the 4 groups provided sufficient opportunities for iterative feedback on the graphic messages to reach a consensus on overall quality and content.

Conclusions
It is feasible and practical to build PR among Black and Latino adolescents focused on vaping prevention. Adolescents added innovation and creativity to the development of culturally and linguistically appropriate graphic messages for vaping prevention. Appropriate staffing, funding, and approaches are key for successful PR efforts among Black and Latino adolescents. Future research is needed to evaluate the impact of the graphic messages on vaping prevention.
A Digital Therapeutic Intervention Delivering Biofeedback for Panic Attacks (PanicMechanic): Feasibility and Usability Study
Authors: McGinnis Ellen , O'Leary Aisling , Gurchiek Reed , Copeland William E , McGinnis Ryan 
Published: November 2021

Background
Panic attacks (PAs) are an impairing mental health problem that affects >11% of adults every year. PAs are episodic, and it is difficult to predict when or where they may occur; thus, they are challenging to study and treat.

Objective
The aim of this study is to present PanicMechanic, a novel mobile health app that captures heart rate–based data and delivers biofeedback during PAs.

Methods
In our first analysis, we leveraged this tool to capture profiles of real-world PAs in the largest sample to date (148 attacks from 50 users). In our second analysis, we present the results from a pilot study to assess the usefulness of PanicMechanic as a PA intervention (N=18).

Results
The results demonstrate that heart rate fluctuates by about 15 beats per minute during a PA and takes approximately 30 seconds to return to baseline from peak, cycling approximately 4 times during each attack despite the consistently decreasing anxiety ratings. Thoughts about health were the most common trigger and potential lifestyle contributors include slightly worse stress, sleep, and eating habits and slightly less exercise and drug or alcohol consumption than typical.

Conclusions
The pilot study revealed that PanicMechanic is largely feasible to use but would be made more so with modifications to the app and the integration of consumer wearables. Similarly, participants found PanicMechanic useful, with 94% (15/16) indicating that they would recommend PanicMechanic to others who have PAs. These results highlight the need for future development and a controlled trial to establish the effectiveness of this digital therapeutic for preventing PAs.
Design and Evaluation of a Smartphone Medical Guidance App for Outpatients of Large-Scale Medical Institutions: Retrospective Observational Study
Authors: Teramoto Kei , Kuwata Shigeki 
Published: November 2021

Background
The greatest stressor for outpatients is the waiting time before an examination. If the patient is able to use their smartphone to check in with reception, the patient can wait for their examination at any location, and the burden of waiting can be reduced.

Objective
This study aimed to report the system design and postintroductory outcomes of the Tori RinRin (TR2) system that was developed to reduce outpatient burden imposed by wait times before examination.

Methods
The TR2 system was introduced at Tottori University Hospital, a large medical facility that accepts a daily average of 1500 outpatients. The system, which links the hospital’s electronic medical record database with patients’ mobile devices, has the following functions: (1) GPS-based examination check-in processing and (2) sending appointment notification messages via a cloud notification service. In order to evaluate the usefulness of the TR2 system, we surveyed the utilization rate of the TR2 system among outpatients, implemented a user questionnaire, and polled the average time required for patients to respond to call notifications about their turn.

Results
The 3-month average of TR2 users 9 months after the TR 2 system introduction was 17.9% (14,536/81,066). In an investigation of 363 subjects, the mean examination call message response time using the TR2 system was 31 seconds (median 14 seconds). Among 166 subjects who responded to a user survey, 86.7% (144/166) said that the system helped reduce the burden of waiting time.

Conclusions
The app allowed 17.9% of outpatients at a large medical facility to check in remotely and wait for examinations anywhere. Hence, it is effective in preventing the spread of infection, especially during pandemics such as that of coronavirus disease. The app reported in this study is beneficial for large medical facilities striving to reduce outpatient burden imposed by wait times.
Physicians’ Attitudes Toward Prescribable mHealth Apps and Implications for Adoption in Germany: Mixed Methods Study
Authors: Dahlhausen Florian , Zinner Maximillian , Bieske Linn , Ehlers Jan P , Boehme Philip , Fehring Leonard 
Published: November 2021

Background
In October 2020, Germany became the first country, worldwide, to approve certain mobile health (mHealth) apps, referred to as DiGA (Digitale Gesundheitsanwendungen, in German, meaning digital health applications), for prescription with costs covered by standard statutory health insurance. Yet, this option has only been used to a limited extent so far.

Objective
The aim of this study was to investigate physicians’ and psychotherapists’ current attitudes toward mHealth apps, barriers to adoption, and potential remedies.

Methods
We conducted a two-stage sequential mixed methods study. In phase one, semistructured interviews were conducted with physicians and psychotherapists for questionnaire design. In phase two, an online survey was conducted among general practitioners, physicians, and psychotherapists.

Results
A total of 1308 survey responses by mostly outpatient-care general practitioners, physicians, and psychotherapists from across Germany who could prescribe DiGA were recorded, making this the largest study on mHealth prescriptions to date. A total of 62.1% (807/1299) of respondents supported the opportunity to prescribe DiGA. Improved adherence (997/1294, 77.0%), health literacy (842/1294, 65.1%), and disease management (783/1294, 60.5%) were most frequently seen as benefits of DiGA. However, only 30.3% (393/1299) of respondents planned to prescribe DiGA, varying greatly by medical specialty. Professionals are still facing substantial barriers, such as insufficient information (1135/1295, 87.6%), reimbursement for DiGA-related medical services (716/1299, 55.1%), medical evidence (712/1298, 54.9%), legal uncertainties (680/1299, 52.3%), and technological uncertainties (658/1299, 50.7%). To support professionals who are unsure of prescribing DiGA, extended information campaigns (1104/1297, 85.1%) as well as recommendations from medical associations (1041/1297, 80.3%) and medical colleagues (1024/1297, 79.0%) were seen as the most impactful remedies.

Conclusions
To realize the benefits from DiGA through increased adoption, additional information sharing about DiGA from trusted bodies, reimbursement for DiGA-related medical services, and further medical evidence are recommended.
Understanding Adoption and Preliminary Effectiveness of a Mobile App for Chronic Pain Management Among US Military Veterans: Pre-Post Mixed Methods Evaluation
Authors: Hogan Timothy P , Etingen Bella , McMahon Nicholas , Bixler Felicia R , Am Linda , Wacks Rachel E , Shimada Stephanie L , Reilly Erin D , Frisbee Kathleen L , Smith Bridget M 
Published: November 2021

Background
The Veterans Health Administration Pain Coach mobile health app was developed to support veterans with chronic pain.

Objective
Our objective was to evaluate early user experiences with the Pain Coach app and preliminary impacts of app use on pain-related outcomes.

Methods
Following a sequential, explanatory, mixed methods design, we mailed surveys to veterans at 2 time points with an outreach program in between and conducted semistructured interviews with a subsample of survey respondents. We analyzed survey data using descriptive statistics among veterans who completed both surveys and examined differences in key outcomes using paired samples t tests. We analyzed semistructured interview data using thematic analysis.

Results
Of 1507 veterans invited and eligible to complete the baseline survey, we received responses from 393 (26.1%). These veterans received our outreach program; 236 (236/393, 60.1%) completed follow-up surveys. We conducted interviews with 10 app users and 10 nonusers. Among survey respondents, 10.2% (24/236) used Pain Coach, and 58% (14/24) reported it was easy to use, though interviews identified various app usability issues. Veterans who used Pain Coach reported greater pain self-efficacy (mean 23.1 vs mean 16.6; P=.01) and lower pain interference (mean 34.6 vs mean 31.8; P=.03) after (vs before) use. The most frequent reason veterans reported for not using the app was that their health care team had not discussed it with them (96/212, 45.3%).

Conclusions
Our findings suggest that future efforts to increase adoption of Pain Coach and other mobile apps among veterans should include health care team endorsement. Our findings regarding the impact of Pain Coach use on outcomes warrant further study.
Порушення ліквороциркуляції в пацієнтів з мальформацією Кіарі: предиктори розвитку сирингомієлітичних кіст і динаміка післяопераційного регресу
Authors: Ktrakyan L.A. , Havryliv T.S. , Smolanka V.I. , Smolanka A.V. , Oros M.M. 
Published: November 2021

Актуальність. Мальформація Кіарі (МК) — це дефект розвитку центральної нервової системи, що проявляється невідповідністю розмірів задньої черепної ямки і розташованих у цій ділянці структур мозку і, як наслідок, опусканням мигдаликів мозочка (МК типу 1), зазвичай з каудальним зміщенням нижніх відділів стовбура мозку, у великий отвір (МК типу 1.5). Унаслідок порушення ліквороциркуляції в 60–90 % пацієнтів із МК спостерігається сирингомієлія. Матеріали та методи. Проведено ретроспективний аналіз клінічних даних 24 пацієнтів із мальформацією Кіарі типу 1 і 1.5, які перенесли оперативні втручання в Ужгородському обласному клінічному центрі нейрохірургії і неврології в період з грудня 2006 р. по грудень 2017 р., під час яких були виконанi субокципітальна декомпресивна краніектомія, ламінектомія на рівні С1, пластика твердої мозкової оболонки. Середній період спостереження після операції становив 5 років. Результати. У пацієнтів, у яких симптоми тривали понад 3 роки, частота утворення сирингомієлітичних кіст становила 57 %. Динаміка регресу порушень ліквороциркуляції в післяопераційному періоді значно варіює залежно від віку. Висновки. Ризик утворення порожнин, заповнених рідиною, у спинному мозку вищий у пацієнтів із МК типу 1 і 1.5, які хворіють понад 3 роки. Хірургічне лікування є ефективним методом, що використовується для корекції порушень ліквороциркуляції. Пункція кісти не є обов’язковою під час хірургічних втручань.
A NEW GENERALIZATION OF M-METRIC SPACE WITH SOME FIXED POINT THEOREMS
Authors: Karapinar Erdal , Roy Kushal , Saha Mantu 
Published: November 2021

In this paper, we introduce a new sequential space as a generalization of M − metricspaces and M b − metric spaces. In this generalized space we define two contractive mappings namely m − contraction and m − quasi-contraction and prove some fixed point theorems for such type of mappings. Several illustrative examples have been presented in strengthening the hypothesis of our theorems.
ON THREE-DIMENSIONAL TRANS-SASAKIAN MANIFOLDS ADMITTING SCHOUTEN-VAN KAMPEN CONNECTION
Authors: Mondal Ashis 
Published: November 2021

In the present paper, we study three-dimensional trans-Sasakian manifolds admitting the Schouten-van Kampen connection. Also, we have proved some results on $\phi$-projectively flat, $\xi-$projectively flat and $\xi-$concircularly flat three-dimensional trans-Sasakian manifold with respect to the Schouten-van Kampen connection. Locally $\phi-$symmetry trans-Sasakian manifolds of dimension three have been studied with respect to Schouten-van Kampen connection. Finally, we construct an example of a three-dimensional trans-Sasakian manifold admitting Schouten-van Kampen connection which verifies Theorem 4.1.
Development Maqashid Sharia Performance in Islamic Bank
Authors: Taufik Muhammad 
Published: November 2021

Islamic banks differ from conventional banks both in philosophy and practice. Its implication is the measurement of performance with financial measures is inappropriate. Maqashid sharia as an alternative continues to develop, so that existing measurements have shortcomings. This study develops the existing measurement of maqashid sharia. The development was carried out in three stages, namely literacy studies, weighted scores, and semi structured interviews. Interviews were conducted with academics of ushul fiqh, Islamic economics, Islamic accounting and practitioners of Islamic banking. Maqashid Sharia Performance (MSP) as a measurement development compiles operational definitions into legal and social requirements. Legal requirements consist of 11 SSB Report indices, 7 product and activity indices, 4 document confirmation indices, 7 zakat indices, and 7 attestation of accounting indices. The social requirements consist of 11 daruriyat ratios, 4 hajiyat ratios, and 2 tahsiniyyat ratios. This research contributes to finding measurements of maqashid sharia that meet the aspects of form and substance and are comprehensive for all levels of daruriyat, hajiyyat, and tahsiniyyat. Â Â Â KeywordsÂ Â Â Â Â Â Â Â Â Â Â Â : maqashid sharia performance, legal requirement, social requirement, financial measurement, Islamic bank
Hak Kekayaan Intelektual Sebagai Wakaf Produktif yang Potensial
Authors: Habibah Syifa 
Published: November 2021

Waqf as an instrument for increasing the welfare ummah is seriously have done by the expansion of waqf property objects. The idea of waqf with movable objects emerged in 2004 with the birth of Law No. 41 of 2004 concerning Waqf. One of the interesting things in Article 16 of the law is the inclusion of provisions which state that Intellectual Property Rights can be used as waqf assets. in this article the author discusses intellectual property such asÂ Â patents and copyrights that have the potential as endowments. the purpose of writing this article is also as a form of information for the public to better understand intellectual property rights as endowments and the potencial of propert rights as productive waqf.