bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum magnesium and zinc levels- A predictor of cardiovascular risk in hemodialysis patients
Authors: Gunavathi G  , Muruganantham B  , Ganesan Harissh , Devi Manasha 
Published: October 2021

Cardiovascular disease is one of the leading causes of mortality in haemodialysis patients. Several studies have demonstrated the relation of zinc and magnesium in cardiovascular disease. In present study we aimed to measure serum zinc and magnesium levels and correlate with the Framingham score to calculate the cardiovascular risk.Present study was prospective, cross sectional type, conducted in chronic kidney disease patients undergoing haemodialysis.Serum magnesium, zinc, cholesterol, urea, creatinine, HDL cholesterol, systolic BP are measured and Framingham score was calculated. And zinc and magnesium values were correlated with Framingham score. The study is conducted in 100 CKD patients undergoing hemodialysis. Out of 100 CKD patients undergoing hemodialysis, 59% had high risk,28% had intermediate risk, and 13% had low risk of developing cardiovascular disease according to their Framingham risk score. In these patients, zinc and magnesium levels were found and correlated with Framingham risk score. Out of 100 patients undergoing hemodialysis, 37 patients were hypomagnesemic, 43 patients were normomagnesemic, 20 patients were hypermagnesemic. In this, a positive correlation was found between development of hypomagnesemia and duration of hemodialysis. Magnesium level was correlated with Framingham risk score. In this hypomagnesemic patients, 67% patients have low risk, 8% have intermediate risk, 24% patients have high risk of developing heart disease. Out of 100 patients, 86 patients have normal zinc level, 14 patients have increased zinc level. Zinc levels was not altered during dialysis. These patients already have risk of developing heart disease independent of zinc level.In our study, magnesium level of haemodialysis patients was reduced and it is associated with duration of haemodialysis. Zinc levels were not altered in the patients.
Oxidative stress in myocardial infarction-does it correlate with the cardiac marker troponin?
Authors: Pallavi R  , Prabha S P  , Cherian Sumina , Venugopal K  , Geetha A  
Published: October 2021

A myocardial infarction (MI), often known as a heart attack, occurs when blood supply to a region of the heart is reduced or stopped, resulting in heart muscle damage. One of the elemental mechanisms responsible for the development of myocardial infarction is oxidative stress. The study aims to assess the Oxidative stress and Troponin I levels in patients with myocardial infarction (MI) and compare them with the level of these parameters in healthy controls. An attempt has been made to find if there is any correlation between oxidative stress and Troponin I levels in patients with myocardial infarction.The Cardiac marker Troponin I and the marker of oxidative stress malondialdehyde were estimated in 30 patients with myocardial infarction and 30 healthy individuals who acted as controls. A statistically significant difference was observed between Troponin I and MDA in patients with MI as compared with controls. A significant positive correlation was also observed between MDA and Troponin I levels. In our study there wasa significant positive correlation between oxidative stress and Troponin I. Further studies with a larger number of subjects will be needed to find if oxidative stress plays a role in the pathogenesis of myocardial infarction.
Evaluation of vitamin D levels in patients with primary hypothyroidism: A cross-sectional study
Authors: Kumari Minakshi , Mahli Rajiv Kumar , Verma Sunil Kumar , Kumar Vinod 
Published: October 2021

Vitamin D deficiency (VDD) and hypothyroidism have been linked in research with inconsistent outcomes. Because of the controversy surrounding these two disorders and their relatively high incidence, we undertook a case-control research comparing the prevalence of VDD in hypothyroid patients (both TPO-Ab positive and negative) to euthyroid controls. This is a cross-sectional study with a single centre. Adults (aged 18 and above) of both sexes with primary hypothyroidism (TSH &#62;5.1 mIU/L) were included (n = 165), as were age and sex matched euthyroid (TSH 5 mIU/ml) controls (n = 165) from the outpatients' department. Biochemical parameters like Thyroid stimulating hormone (TSH), free T4 (fT4), 25 hydroxy vitamin D (Vit D) and thyroid peroxidase antibody (TPO-Ab) were tested in both the groups.The study involved 330 patients, with 165 (mean age 46± 15 years) having primary hypothyroidism (3 having subclinical hypothyroidism) and 165 (mean age 45± 17 years) being euthyroid controls. VDD was seen in 96 percent of hypothyroid patients compared to 90 percent in the control group. The hypothyroid group had a significantly lower mean Vitamin D level than the euthyroid group (12.03± 8.6 SD vs. 17.49± 11.89 SD [ng/ml]; P= 0.001). TPO-Ab was found in two-thirds of the hypothyroid group (110/165). The mean Vitamin D level in the TPO-Ab positive hypothyroid group was 10.4± 7.2 ng/ml, compared to 15.3± 10.3 ng/ml in the TPO-Ab negative group (P = 0.004). With increased TPO-Ab titers, there was a downward trend in Vitamin D levels. A direct association between Vitamin D levels and TPO-Ab, on the other hand, did not reveal any relevance. Patients with hypothyroidism had considerably lower vitamin D levels than euthyroid controls. TPO-Ab positive individuals had lower vitamin D levels than TPO-Ab negative patients.
Cord serum leptin in infants born to diabetic mothers
Authors: Vani K , Dolia Pragna B 
Published: October 2021

In genetically diabetes-prone populations, maternal diabetes during pregnancy increases the risk of their children developing diabetes and obesity (the vicious cycle of type 2 diabetes). Fetal hyperinsulinemia at birth acts as a marker of this risk. The objective of this study is to find out whether cord blood leptin concentrations are increased in offspring of mothers with type 2 and gestational diabetes mellitus (GDM) and to evaluate gender differences if any, in their levels.Cord Serum Leptin measured by ELISA: 1. Cord Blood from 40 babies (20M, 20F) born to GDM Mothers. 2: Cord Blood from 20 babies (9M, 11F) born to Type 2 DM Mothers. 3. Cord Blood from 30 babies (15M, 15F) born to Non Diabetic Mothers. Babies born to mothers with both type 2 diabetes and GDM had higher birth weight. They also had higher Leptin concentrations [ng/ml] compared to Controls; Leptin concentrations in Type 2 Diabetes -Mean [42.32+24.09], in GDM – Mean [40.31+22.71] & in Control subjects – Mean [23.87+15.48]. Birth weight of the female babies were also higher than that of male babies.Leptin concentrations were not significantly higher in the female babies in comparison to the male babies.High cord leptin, birth weight and ponderal index (kilograms per cm), in babies born to Type 2 diabetes and GDM mothers.
OSPE in Biochemistry –A step towards implementation of competency based undergraduate curriculum
Authors: Anees Syyeda , Harakuni Sheetal , Kausar Ruksana 
Published: October 2021

Competency based undergraduate curriculum stresses on objectivity, uniformity, validity and reliability of the assessment tools since assessment drives learning. Conventional Practical Examination (CPE) in Biochemistry is subjective and associated with examiner variability and raises concerns over its validity and reliability. Objective Structured Practical Examination(OSPE) addresses this problem as it includes objective testing through direct observation, assessment of knowledge, comprehension and skills.In this study the performance of 1 MBBS students in CPE & OSPE was compared & perception of students and faculty towards OSPE as Formative Assessment was evaluated. Study included total of 150 Phase 1 MBBS students of 2019-20 batch & faculty of Biochemistry were included. CPE and OSPE was conducted on topic “Estimation of Blood Glucose” and marks were awarded.OSPE was conducted with 2 procedure & 4 response stations. Statistical Analysis: Percentage graphs & Student’s’ test using MS Excel were used. There was statistically significant difference between the mean scores of CPE and OSPE (P &#60; 0.01). Our study concludes that the scores of OSPE were better than that of CPE. OSPE eliminated examiner bias by integration of cognitive, psychomotor and affective domains. Therefore OSPE can be introduced as Formative Assessment & Summative Assessment.
Comparison of external dacryocystorhinostomy versus injection botulinum toxin in the management of functional epiphora
Authors: Rana Aakankshya , Sthapit Purnima Rajkarnikar , Limbu Ben , Amatya Malita , Saiju Rohit 
Published: October 2021

To compare the efficacy of external dacryocystorhinostomy (DCR) and botulinum toxin-A in the management of functional epiphora.A prospective, comparative, interventional study included 45 patients with functional epiphora out of which 20 patients had undergone external dacryocystorhinostomy and 25 patients received 5 units of injection botulinum toxin in the palpebral lobe of lacrimal gland as per the patient’s preference. All patients underwent syringing and fluorescein dye disappearance testing before the procedure. Epiphora was graded subjectively with Munk scores obtained before and after intervention. Duration of side effects and severity were also noted.This study showed functional epiphora common in elderly age group. Female constitued of 71.11% and male 28.89 % with female: male ratio of 2.4:1. Left eye (42.22%) predominantly involved. The overall success rate at 6 months after surgery for external DCR was 95% and that of injection botulinum was 91.17%. The overall success rate in both the group was not statistically significant(p&#62;0.05%). Improvement in epiphora graded by Munk score was statistically significant after intervention in both the groups(p&#60;0.05%). This study showed injection Botulinum toxin can be considered as an alternative management in case of functional epiphora for patient who do not want to undergo surgical intervention and for those with co-morbid conditions with high risk for surgical intervention like DCR.
A study of ocular morbidity related to trauma and role of B-Scan in its diagnosis and management
Authors: Agrawal Sahil , Rizvi Yusuf , Rai Aniket , Gupta Saloni 
Published: October 2021

Ocular trauma is an important cause of visual impairment worldwide. The reported annual incidence of severe ocular trauma is 9.75 per 1,000 adults. Ultrasonography (B scan) has emerged as a useful technique in ocular injury scenario. We aimed to evaluate role of B Scan ultrasonography in management of ocular injuries.All patients with ocular trauma attending the emergency department were enrolled for the study. Relevant history and demographic data was noted on the study proforma. Detailed ocular examination was done employing slit lamp biomicroscopy for anterior segment and direct and indirect ophthalmoscopy for posterior segment evaluation. All patients were necessarily subjected to B scan ultrasonography (USG) for additional clinical information. A total of 50 cases were enrolled. The mean age of affection was 28 years. The most common mode of injury was agriculture related. The most common anterior segment finding was traumatic cataract as seen in 22(44%) cases while on USG posterior vitreous detachments seen in 36% cases, followed by retinal detachment in 24% cases and vitreous haemorrhage in 22% cases. Choroidal detachment was accurately localized in 2% cases.The study emphasizes the need for B-scan as a valuable tool in the diagnosis of posterior segment pathologies particularly when the media has become opaque as it can visualize and localize the position of the lesions which would not be possible by any other means.
Awareness regarding COVID-19 among auxiliary dental staff in a tertiary dental care centre in Kerala- A cross-sectional study
Authors: Thomas Sherin Ann , Asish R  , Vinimol C  , Bhaskar Bindu V , Jacob Jesmith Elsa 
Published: October 2021

Corona virus disease officially called as COVID-19, declared a “pandemic” by the World Health Organization; became a major public health problem causing worldwide morbidity and mortality, despite various control measures. Extraordinary measures are taken universally to fight the spread of the ongoing outbreak. In such a scenario, people’s adherence to preventive measures is largely influenced by their knowledge and perception of the disease. Since dental care professionals are having high chances of infectivity, which in turn has serious implications, it is essential that the auxiliary dental staff must be educated, empowered and provided appropriate and relevant knowledge of the disease.To assess the level of awareness regarding COVID-19 among auxiliary dental staff in a Tertiary Dental Care Centre in Kerala.A cross sectional survey was conducted among all the auxillary staff in a tertiary dental care centre by an online questionnaire through google forms. Details regarding demographic data, knowledge about the spread, symptoms, diagnosis, prevention and safety practices related to COVID-19 were obtained after getting an online informed consent. Descriptive statistics and Chi square test were done. Associations and differences were considered significant when the p value was less than 0.05.The initial sample size was 50. Forty two participants completed the study. Out of the participants 36% (n=15) were below 40 years and were males. About 40.5% (n=17) had experience less than 5 years. Around 69% (n=23) of the participants had good knowledge regarding COVID 19. Statistically significant results were seen with mode of transmission of Covid 19 and age of the respondents (p value=.006);current treatment of Covid 19 and years of experience of the respondents (p value=.011).The study concluded that there is overall good awareness level among the participants of the study.
Knowledge and ability to manage medical emergencies among dental students
Authors: Prashanthi Chitturi , Patil Prashant B , Joshi Vajendra , Kumar K R Kiran , Shilpa R T  
Published: October 2021

: An emergency can be encountered anytime and anywhere. Minimal knowledge about medical emergency and their etiology, primary protocol for management must be known to avoid potential consequences. Hence, the present study was undertaken to compare the knowledge, and ability to handle the medical emergencies among the dental students.A cross-sectional survey was conducted among 100 randomly selected dental students (post-graduate students and interns) comprising of two groups of students those who had underwent training and those who did not. The data obtained was analyzed using the SPSS for windows version 22.0 released 2013.Independent chi square test was used for comparison of responses and independent student t-test was used for the comparison of mean scores. The significance level was set at p&#60;0.001.: The average mean knowledge and ability score was 68% & 61.4% respectively among the participants. On further comparison of mean knowledge & ability scores between the participants with & without basic life support training, participants with BLS training showed better knowledge than those without training and the difference was statistically significant between the two groups (p&#60;0.001%).The study found deficiencies in the knowledge and ability of untrained graduates to deal with medical emergencies as compared to trained.
Effect of Foliar Nutrition and Crop Geometry on Cultivars of Blackgram in Shiwalik Foothills of Jammu
Authors: Sagar Lalichetti , Singh A.P. , Singh Sultan , Praharaj Subhashisa 
Published: October 2021

Background: Rapid expansion in population increased the global food demand. To meet this surge in demand for food and to ensure food and nutritional security addition of pulses in the cropping system is a visible alternative. Pulses intensifies cropping intensity, enhances health and fertility status of the soil and acts as a good source of dietary protein etc. However, due to a wide gap between the potential and actual yield of pulses in rainfed areas. Hence, identification and adoption of best management practices has become a pre-requisite. The present study was undertaken as the information available on foliar nutrition and different crop geometries on performance of different blackgram genotypes in rainfed condition is meagre. Methods: In this investigation conducted during kharif season of 2018 at Advanced Centre for Rainfed Agriculture, SKUAST-Jammu, Rakh Dhiansar. The experiment was laid out in factorial randomized block design with 3 factors and 3 replications. The factor-1 consisted of three blackgram cultivars (Uttara, PU-31 and Mash-114), factor 2 consisted of two crop geometries (30×10 cm and 45×10 cm) and factor-3 consisted of three foliar nutrition (Foliar spray of molybdenum as sodium molybdate @ 0.1% at 20 DAS, Foliar spray of 1.5% KCl at flowering and Foliar spray of molybdenum as sodium molybdate @ 0.1% at 20 DAS fb 1.5% KCl at flowering). Result: The results from the present investigation indicated that adoption of Mash-114 at 30×10 cm crop geometry, supplemented with foliar application of molybdenum as sodium molybdate @ 0.1% at 20 DAS fb 1.5% KCl at flowering could be a viable technological proposition under rainfed conditions of Jammu.
Analysis of Renewable Energy Directive Ii on Trading of Indonesian Palm Oil Associated with GATT
Authors: Chairunisa Amanda Fadhilla , Haryanto Imam 
Published: October 2021

International economic relations sure is very important for a country and the important thing that follows is the policy that regulates international economic relations it self. In this study, the authors will analyze hows Renewable Energy Directive II (RED II) policy as a derivative of the RED (Renewable Energy Directive) policy by the European Union will affect the Indonesian palm oil trade which this also would show the violations of previous policies that is General Agreement on Tarifs and Trades. Authors also going to show General Agreement on Tariffs and Trade (GATT) as a policy that regulates how international trade relations should be carried out and the violations of this international agreement undoubtedly could affect Economic relations between the two countries, both on a micro scale and macro scale. In conducting the research authors will be using the normative juridical methods which means the legal research will be based off library materials and secondary materials therefore the main result from this study would be a reflection of how RED II can affect trade in indonesian palm oil products and also by effecting this regulation in 2021 the european union will be violating the non-discrimination principle in GATT 1947.
Influence of Alcoholic and Malolactic Fermentation on the Level of Biogenic Amines in Wine
Authors: Ageyeva Natalia , Shirshova Anastasia , Tikhonova Anastasia 
Published: October 2021

Introduction. The concentration of biogenic amines is an important indicator of the safety of food products, especially winemaking. In grape wines, this concentration varies widely depending on the grape variety, its microbiological state, processing technology, the race of yeast and bacteria of malolactic fermentation, conditions of alcoholic and malolactic fermentation, etc. This research is aimed at determining the effect of the production technology of dry white and red wines on the concentration of biogenic amines.
Study objects and methods. The mass concentration of biogenic amines was determined by the method of high-performance capillary electrophoresis using a Kapel 105R in laboratory-obtained samples of dry white wine from the Chardonnay grape variety and table dry red wine from the Cabernet-Sauvignon grape variety.
Results and discussion. The dry white wine samples revealed high concentrations of tyramine (1.12 mg/dm³), phenylethydamine (0.58 mg/dm³), and histamine (0.57 mg/dm³), while the red wine samples demonstrated tyramine (0.62 mg/dm³), histamine (0.45 mg/dm³), putrescine (0.43 mg/dm³), and cadaverine (0.38 mg/dm³). The white wine samples had optimal pH values (3.2–3.6) with minimal formation of biogenic amines. The red wine samples, especially those obtained by heat treatment, had a lower concentration of biogenic amines, especially volatile biogenic amines, i.e. methylamine and phenylethylamine. The greatest formation of biogenic amines occurred during the acid reduction process: under the effect of enzymes of malolactic bacteria, biogenic amines formed as a result of decarboxylation of amino acids.
Conclusion. The technology of production of table dry white and red wines affects the concentration of biogenic amines. To reduce the level of biogenic amines in the finished product, each stage of vinification has to be controlled, especially the stages of fermentation and acid reduction (temperature and pH). The race of yeast and lactic acid bacteria cannot include those that produce biogenic amines or introduce them in minimal quantities.
Improvement of Technological Indicators of Semi-Finished Products of Sugar Production from Bacterially Infected Sugar Beet
Authors: Belyaeva Lubov , Pruzhin Michail , Ostapenko Alla , Gurova Valentina 
Published: October 2021

Introduction. Technological aids play a special role in sugar production technology, but their complex effectiveness requires a comprehensive and in-depth study. The research objective was to establish the patterns of change in the technological indicators of semi-finished products obtained from bacterially infected sugar beets with the combined use of an enzyme preparation, antimicrobial agent, and defoamer.
Study objects and methods. The study involved such semi-finished products as juice (diffusion, pre-defecated, first and second saturation) and syrup, the quality of which was determined according to standard methods. The laboratory experiment was carried out on the basis of the second-order D-optimal Box-Behnken plan for three factors at three levels.
Results and discussion. The research revealed positive dynamics of the following technological indicators: sucrose content, deposition rate, turbidity, chromaticity, and general purification effect. The sugar beet had the second degree of infection with mucous bacteriosis. Purified juice underwent lime-carbon dioxide purification and thickening under the combination of enzyme preparation Dextrasept 2, antimicrobial agent Betasept, and antifoam agent Voltes FSS 93. The greatest increase in sucrose at the level of 1.1% by DM weight was confirmed by a higher overall effect of purification of diffusion juice (2.2 %). The values of turbidity of the purified juice and syrup were below the threshold values. The low values resulted from the increase in the sedimentation rate of the pre-defective juice and the juice of the first saturation by an average of 4.1 and 3.2 times, respectively, due to the effective removal of high molecular weight compounds. The share of the enzyme preparation was 40–71%, antimicrobial agent – 19–49%, defoamer – 1.6–6.5%. The values of the multicriteria optimization parameter corresponded with technological indicators. The optimal combination (per 1000 tons of beets) included 6–8 kg of Dextrasept 2, 1.5–2.0 kg of Betasept, and 15–20 kg of Voltes FSS 93. As a result, the yield of white sugar increased by 0.25%.
Conclusion. The regression dependencies can be recommended for predicting the main technological indicators of semi-finished products. The resulting data makes it possible to determine the effectiveness of the combined use of an enzyme preparation, antimicrobial agent, and defoamer in sugar production. Further research will identify the patterns of multifactorial interaction of these preparations.