bluuebunny/crossref_metadata_2025_split huggingface dataset:
How catchment characteristics influence hydrological pathways and travel times in a boreal landscape
Authors: Jutebring Sterte Elin , Lidman Fredrik , Lindborg Emma , Sjöberg Ylva , Laudon Hjalmar 
Published: April 2021

Abstract. Understanding travel times and hydrological pathways of rain and snowmelt
water transported through the landscape to recipient surface waters is
critical in many hydrological and biogeochemical investigations. In this
study, a particle-tracking model approach in Mike SHE was used to investigate the pathway and its associated travel time of water in 14 partly
nested, long-term monitored boreal sub-catchments of the Krycklan catchment
(0.12–68 km2). This region is characterized by long and snow-rich winters with little groundwater recharge and highly dynamic runoff during spring snowmelt. The geometric mean of the annual travel time distribution
(MTTgeo) for the studied sub-catchments varied from 0.8 to 2.7 years. The variations were related to the different landscape types and their varying
hydrological responses during different seasons. Winter MTTgeo ranged from 1.2 to 7.7 years, while spring MTTgeo varied from 0.5 to 1.9 years. The modelled variation in annual and seasonal MTTgeo and the fraction of
young water (<3 months) was supported by extensive observations of
both δ18O and base cation concentrations in the different
streams. The travel time of water to streams was positively correlated with the area coverage of low-conductive silty sediments (r=0.90, P<0.0001). Catchments with mixed soil–landscape settings typically displayed larger variability in seasonal MTTgeo, as contrasting hydrological
responses between different soil types (e.g. peat in mires, till and silty
sediments) are integrated. The areal coverage of mires was especially
important for the young water contribution in spring (r=0.96, P<0.0001). The main factor for this was attributed to extensive soil frost in
mires, causing considerable overland flow during the snowmelt period.
However, this lower groundwater recharge during snowmelt caused
mire-dominated catchments to have longer stream runoff MTTgeo than
comparable forest catchments in winter. Boreal landscapes are sensitive to
climate change, and our results suggest that changes in seasonality are
likely to cause contrasting responses in different catchments depending on
the dominating landscape type.
Endoscopic Tympanoplasty: Inlay Cartilage Versus Underlay Cartilage Graft
Authors: Doblan Ahmet , Sevil Ergun 
Published: April 2021

Aim: Several graft placement methods have been described in tympanoplasty. The aim of this study is to assess the surgical effects of the endoscopic tympanoplasty utilizing inlay cartilage or underlay cartilage graft.
Methods: We reviewed medical records of 123 patients who experienced endoscopic tympanoplasty for chronic otitis media with a minimum twelve-month follow-up period. Perforations were divided into central, posterior, and anterior ones based on the place of the perforation to malleus handle. Graft success rate, air conduction pure tone audiometry (PTA) before surgery and after surgery, hearing gain and air bone gap (ABG) reduction were calculated following surgery.
Results: No significant difference was found between the groups in terms of the distribution of the follow-up period, age, perforation location, and gender (p>0.05). The average air conductions (AC) before surgery and after surgery for the inlay group were 36.3 ± 13.7 dB and 25.4 ± 12.3 dB 6 months after surgery and 22.5 ± 10.5 dB 12 months after surgery. They were 35.6 ± 13.3 dB and 24.8 ± 12.4 dB 6 months after surgery and 22.7 ± 9.7 12 months after surgery for the underlay group. A significant difference was found between the two groups in terms of ABG (P=0.037). There was no significant difference in the mean ABG in each group (small perforation P =0.473, medium perforation P=0.876 and large perforation P=0.341).
Conclusion: The inlay method can be used with high graft success rate, low risk of complications among the appropriate patients, and shorter operation time as a reliable surgical option for treatment.
HUBUNGAN ANTARA TEKANAN INTRAUTERIN TERHADAP KEJADIAN KETUBAN PECAH DINI DI RUMAH SAKIT IBU DAN ANAK SRIKANDI IBI JEMBER.
Authors: Prasetya Fika Indah 
Published: April 2021

Ketuban pecah dini yang tidak segera diikuti dengan tanda persalinan memberikan peluang besar pada mikroorganisme masuk kedalam tubuh janin melalui vagina. Para ahli kebidanan menyepakati bahwa KPD lebih dari 18 jam dianggap risiko terjadinya infeksi neonatus.
Desain dalam penelitian ini adalah korelasi dengan menggunakan pendekatan restrospective yaitu dengan menggunakan data pasien yang terdapat dala Rekam Medik di RSIA Srikandi IBI Jember dengan sampel sebanyak 30 responden. Hasil dari penelitian diperoleh bahwa Hubungan antara Tekanan Intrauterine terhadap kejadian Ketuban Pecah Dini di Rumah sakit Ibu dan Anak Srikandi Jember.
HUBUNGAN DUKUNGAN KELUARGA DENGAN KEPATUHAN LANSIA MELAKUKAN KONTROL KESEHATAN DI POSYANDU LANSIA DI DESA AFDELING SUMBERBARU KECAMATAN KALIBARU KABUPATEN BANYUWANGI
Authors: Prasetya Fika Indah 
Published: April 2021

Dukungan keluarga adalah informasi verbal, sasaran, bantuan yang nyata atau tingkah laku yang di berikan oleh orang orang yang akrab dengan subjek di dalam lingkungan sosialnya atau yang berupa kehadiran dan hal yang dapat memberikan keuntungan emosional atau pengaruh pada tingkah laku penerimanya. Lansia adalah individu yang berada dalam tahapan usia late adlthood atau yang di maksud dengan tahapan usia dewasa akhir.
Tujuan penelitian ini menganalisis Hubungan Keluarga Dengan Kepatuhan Lansia Melakukan Kontrol Kesehatan di Posyandu lansia di Desa Afdeling Sumberbaru Kecamatan Kalibaru Kabupaten Banyuwangi.
Metode Penelitian ini menggunakan metode penelitian analitik dengan pendekatan cross sectional. Pengambilan sampel menggunakan teknik Total sampling, dengan jumlah sampel sebanyak 40 yang memenuhi kriteria, instrumen pada penelitian ini menggunakan koesioner dan observasi.
Hasil analisa univariat menunjukkan sebagian besar responden memiliki dukungan keluarga baik sebanyak 8 (20.0%) dan responden yang patuh sebanyak 24 (60.0%). Analisa bivariat dengan menggunakan Contingency Coefficient didapatkan hasil (p-value) 0.000. Nilai p-value lebih kecil dari 0.05 (0.000 a < 0.05), yang artinya ada hubungan antara dukungan keluarga dengan kepatuhan lansia melakuan kontrol kesehatan di posyandu lansia. Kesimpulan Ada Hubungan Dukungan Keluarga Dengan Kepatuhan Lansia Melakukan Konrol Kesehatan di Posyandu Lansia Di Desa Afdeling Sumberbaru Kecamatan Kalibaru Kabupaten Banyuwangi.
Dukungan keluarga juga merupakan salah satu faktor yang mempengaruhi tingkat kepatuhan lansia melakukan kontrol kesehatan di posyandu lansia di Desa Afdeling Sumberbaru, hal ini di karenakan keluarga dapat menentukan keyakinan, nilai kesehatan serta menentukan program pengobatan bagi lansia yang sakit.
VALIDAÇÃO DE UM OPINÁRIO SOBRE AQUECIMENTO GLOBAL
Authors: Junges Alexandre Luis , Da Silveira Fernado Lang , Massoni Neusa Teresinha 
Published: April 2021

O aquecimento global tem sido reconhecido por especialistas como um tema prioritário da agenda da educação ambiental para o século 21. Cientistas têm alertado sobre a necessidade de lidar com o desafio das mudanças climáticas causadas pelas emissões antropogênicas de gases de efeito estufa. Apesar disso, a percepção sobre o tema entre o público leigo é difusa. No contexto internacional, estudos têm revelado que um número considerável de cidadãos leigos não acredita em aquecimento global antropogênico, ou consideram que não existe consenso científico a respeito dessa matéria. Neste sentido, tendo em vista a importância do tema e as diferenças de opinião entre o leigo e o especialista, averiguadas em contextos internacionais, torna-se relevante desenvolver pesquisas similares no contexto brasileiro local. O presente trabalho descreve o desenvolvimento de um instrumento de medida capaz de avaliar a opinião de cidadãos e alunos em diferentes níveis de ensino, no contexto brasileiro, sobre a temática do aquecimento global. Para tanto, são descritos os passos de desenvolvimento, aplicação e validação de um opinário sobre aquecimento global. O opinário, composto de doze itens, foi disponibilizado online em redes sociais e listas de e-mails através do software LimeSurvey, obtendo-se um total de 1084 respostas. Descrevemos o processo de validação de conteúdo e de construto do opinário que culminou em um instrumento de medida apropriado para quantificar o grau de concordância ou discordância de sujeitos frente ao construto “aquecimento global antropogênico”. Por fim, são discutidas possíveis correlações entre as variáveis de caracterização da amostra de sujeitos e a crença no aquecimento global antropogênico.
Contribuições das disciplinas experimentais da Licenciatura em Física para a formação dos saberes docente
Authors: Marques Nelson Luiz Reyes , Orengo Gilberto 
Published: April 2021

As pesquisas apontam lacunas na formação inicial de professores, principalmente, devido a separação entre os saberes disciplinares e os saberes pedagógicos. Também mostram que as aulas de laboratório estão associadas a roteiros fechados e centradas no modelo aplicacionista, priorizando os conhecimentos específicos da Física e o método científico, em detrimento de uma formação pedagógica adequada para a sua utilização no Ensino Médio, ignorando seu potencial mediador para a Transposição Didática dos saberes. Este trabalho apresenta resultados de uma pesquisa desenvolvida com o objetivo de avaliar as contribuições das disciplinas de Física Experimental das Licenciaturas em Física para a construção dos saberes docentes, a partir dos conceitos de saberes propostos por Tardif e da Transposição Didática na visão de Chevallard. A metodologia de pesquisa foi o estudo de caso qualitativo, referenciado em Stake. Como instrumento para coleta de dados foram utilizados questionários, aplicados online para 65 professores de todo o Brasil, e entrevistas semiestruturas, aplicadas para 16 professores formados nas universidades do Rio Grande do Sul que apresentam Licenciatura e Bacharelado. A pesquisa mostrou a necessidade de uma atualização das disciplinas de Física Experimental da Licenciatura em Física, a fim de que contribuam mais significativamente para a formação dos professores que atuam no Ensino Médio.
Is Obesity Associated With an Increased Risk of Complications After Surgical Management of Acetabulum and Pelvis Fractures? A Systematic Review
Authors: Mittwede Peter N. , Gibbs Christopher M. , Ahn Jaimo , Bergin Patrick F. , Tarkin Ivan S. 
Published: April 2021

Background:
When considering surgical fixation of acetabulum and pelvis fractures in patients with obesity, a thorough understanding of the risks of potential complications is important. We performed a systematic review to evaluate whether obesity is associated with an increased risk of complications after surgical management of acetabulum and pelvis fractures.

Methods:
We searched PubMed/MEDLINE, EMBASE, and the Cochrane Library for studies published through December 2020 that reported the effect of increased body mass index (BMI) or obesity on the risk of complications after surgical treatment of acetabulum and pelvis fractures.

Results:
Fifteen studies were included. Eight of the 11 studies that included infection or wound complication as end points found that increased BMI or some degree of obesity was a significant risk factor for these complications. Two studies found that obesity was significantly associated with loss of reduction. Other complications that were assessed in a few studies each included venous thromboembolism, nerve palsy, heterotopic ossification, general systemic complications, and revision surgery, but obesity was not clearly associated with those outcomes.

Conclusions:
Obesity (or elevated BMI) was associated with an increased risk of complications—infection being the most commonly reported—after surgical management of acetabulum and pelvis fractures, which suggests the need for increased perioperative vigilance.
Steekwapens binnen de Wet wapens en munitie
Authors: Geurts J. (Jeroen) 
Published: April 2021

Het voornemen tot een algeheel draagverbod van messen voor minderjarigen bezien na een analyse van de huidige wet.
Via een brief aan de voorzitter van de Tweede Kamer lieten ministers Grapperhaus en Dekker weten met een actieplan te komen om het (steek)wapenbezit en -gebruik onder jongeren aan banden te leggen. Als onderdeel van dit plan wordt een algeheel draagverbod van alle messen genoemd. In deze bijdrage wordt beschreven welke voorwerpen onder welke omstandigheden als strafbaar steekwapen onder de WWM vallen. Vervolgens wordt, bezien vanuit de huidige WWM, beschreven waarmee de wetgever rekening moet houden als deze over wil gaan tot een algeheel draagverbod van messen voor minderjarigen.
Onde se graduam os Médicos de Família e Comunidade do Brasil?
Authors: Sarti Thiago Dias , Fontenelle Leonardo Ferreira , Oliveira Bruno Luciano Carneiro Alves de , Rossi Stephani Vogt , Oliveira Miguel Henrique Moraes de , Almeida Ana Paula Santana Coelho 
Published: April 2021

Pouco se sabe sobre as características da graduação médica dos Médicos de Família e Comunidade do Brasil. Objetivo: caracterizar as instituições de ensino superior (IES) onde se graduaram os médicos que se especializaram em medicina de família e comunidade no Brasil até 2018. Métodos: estudo descritivo baseado em dados secundários dos currículos Lattes de todos os MFCs que atuam no Brasil, compreendendo informações sobre o local e ano de graduação do médico. Resultados: foram localizados os currículos de 4.065 (65,2%) dos 6.238 MFCs identificados, sendo que 3.889 (62,3%) registraram a IES na qual se graduaram em medicina. 3.769 (96,9%) MFCs se formaram em 169 IES brasileiras e 120 (3,1%) se formaram em 48 IES estrangeiras. A maioria dos MFC se graduaram em IES públicas (n=2.396; 63,8%), localizadas em cidades com mais de 100 mil habitantes (n=3.446; 96,7%) e nas regiões sul e sudeste do país. A região Sudeste concentrou as IES responsáveis pela graduação de mais de 45,0% dos MFCs. Todos os estados das regiões Nordeste, Centro-Oeste e Norte respondem, cada um, pela graduação de menos de 4,5% do total de MFCs do Brasil. As IES privadas ganharam maior importância na graduação de MFC a partir de 2008. Conclusão: a maior parte dos MFC que obtiveram seus títulos da especialidade no Brasil foram graduados em medicina no próprio país, em IES públicas localizadas nos grandes centros urbanos das regiões sul e sudeste do país, padrão que se assemelha ao da formação médica em geral.
Long distance dispersal and pseudo-cryptic species in Gastrotricha: first description of a new species (Chaetonotida, Chaetonotidae, Polymerurus) from an oceanic island with volcanic rocks
Authors: Magpali Letícia , Machado Danilo R.P. , Araújo Thiago Q. , Garraffoni André R.S. 
Published: April 2021

The majority of meiofaunal organisms have limited abilities to disperse over long distances, yet they may still have disjointed distributions. Many studies have found evidence of long distance meiofauna dispersal due to passive transport by wind and/or animals that serve as vectors for these widespread distributions. Our research on an archipelago in northeast Brazil uncovered a species of freshwater gastrotrich that at first sight appeared to be a ‘cosmopolitanʼ species that had surpassed the connectivity constraint to occupy an island more than 350 km from the mainland. However, through an integrative approach using molecular sequences and morphology, we have uncovered evidence of a pseudo-cryptic species in this freshwater gastrotrich. Polymerurus insularis sp. nov. closely resembles its congeners and can easily be mistaken for similar species such as P. nodicaudus, a cosmopolitan gastrotrich. Unique to P. insularis sp. nov. are (1) a cuticular armature composed of simple spined scales with polygonal shape (Type 1 scales), (2) a single, spineless dorsal scale with a triangular shape located terminally next to the furca base (Type 2 scale), (3) a spineless zone composed by a patch lacking cuticular ornamentation and flat, rounded or polygonal scales without spines (Type 4 scales) (4) particular sets of terminal spined or keeled scales located both dorsally and ventrally around the furca base (Types 3, 5, 6, 7 and 8 scales). The presence of this species on a volcanic island is discussed, as is the relationship between pseudocryptism and dispersal in gastrotrichs and other meiofauna.
Prevalence of depression and its impact on quality of life in frontline otorhinolaryngology nurses during the COVID-19 pandemic in China
Authors: Tian Zi-Rong , Xie Xiaomeng , Li Xiu-Ya , Li Yue , Zhang Qinge , Zhao Yan-Jie , Cheung Teris , Ungvari Gabor S. , An Feng-Rong , Xiang Yu-Tao 
Published: April 2021

ObjectiveExposure to the coronavirus disease 2019 (COVID-19) was associated with high risk of mental health problems among frontline nurses. This study examined the prevalence of depressive symptoms (depression hereafter) and its impact on quality of life (QOL) in otorhinolaryngology (ENT) nurses during the COVID-19 pandemic in China.MethodsAn online study was conducted between March 15 and March 20, 2020. Depression and QOL were assessed using standardized instruments.ResultsA total of 1,757 participants were recruited. The prevalence of depression was 33.75% (95% CI: 31.59%-35.97%). Results emerging from multiple logistic regression analysis showed that direct care of COVID-19 patients (OR: 1.441, 95% CI: 1.031–2.013,P = 0.032), and current smoking (OR: 2.880, 95% CI: 1.018–8.979,P = 0.048) were significantly associated with depression. After controlling for covariates, ENT nurses with depression had a lower overall QOL compared to those without depression (F(1, 1757)= 536.80,P < 0.001).ConclusionsDepression was common among ENT nurses during the COVID-19 pandemic in China. Considering the negative impact of depression on QOL and care quality, regular screening for depression should be conducted in ENT nurses and treatment should be provided.
CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma
Authors: Fan Chunmei , Tan Fenghua , Wu Jie , Zeng Zhaoyang , Guo Wenjia , Huang He , Xiong Wei 
Published: February 2025

Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor with high metastasis. Circular RNAs (circRNAs) are involved in tumor progression, but their functions and mechanisms are not well understood. Vasculogenic mimicry (VM) has been discovered as an alternative way to supply tumor nutrition and accelerate tumor progression, including NPC. We previously found that circCCNB1 (derived from cyclin B1) could inhibit the migration and invasion of NPC cells by binding to nuclear factor 90 (NF90), however, whether circCCNB1 has additional biological functions is still unclear. In this study, the effects of circCCNB1 binding to NF90 on the generation of miR‐15b‐5p and miR‐7‐1‐3p were detected using qRT‐PCR, western blotting, RNA pulldown, ribonucleoprotein immunoprecipitation and truncated experiments. VM formation assays were used to assess their biological functions. We found that circCCNB1 promoted the processing and generation of miR‐15b‐5p and miR‐7‐1‐3p through competitive binding to NF90, thereby inhibiting the expression of calumenin (CALU), kinesin family member 1B (KIF1B), RNA polymerase III subunit G (POLR3G), ultimately decreasing the VM of NPC cells. This study not only reveals a new function of circCCNB1 in NPC, but also provides new insights for targeting angiogenesis therapy.
Comparative Effectiveness and Safety of the JAK Inhibitors and Biologic Disease‐Modifying Antirheumatic Drugs in Treating Children With Nonsystemic Juvenile Idiopathic Arthritis: A Bayesian Meta‐Analysis of Randomized Controlled Trials
Authors: Li Yuxiang , Huang Bin , Andorf Sandra , Yue Xiaomeng , Lovell Daniel J. , Brunner Hermine I. 
Published: February 2025

ObjectiveWe evaluated the efficacy and safety profiles of JAK inhibitors (JAKi) and biologic disease‐modifying antirheumatic drugs (bDMARDs) when used with or without methotrexate (MTX) for the treatment of nonsystemic forms of juvenile idiopathic arthritis (nsJIA).MethodsRandomized clinical trials (RCTs) investigating efficacy and safety outcomes of JAKi or bDMARDs for the nsJIA population up to 2023 were searched in ClinicalTrial.gov, PubMed, EMBASE, and Cochrane databases. Bayesian arm‐based network meta‐analysis compared efficacy as measured by Juvenile Idiopathic Arthritis‐American College of Rheumatology 70 (JIA‐ACR70) improvement and safety based on rates of serious adverse events (SAEs) among all therapies.ResultsEligible studies included 45 citations from 16 RCTs (7 parallel and 9 withdrawal trials) with a total of 1,821 participants that investigated nine bDMARDs, three with and six without MTX co‐treatment, and two JAKis (tofacitinib and baricitnib). The reported SAE incidence rates ranged from 0 to 0.3 per person‐year of follow‐up; none of the pairwise comparisons were statistically significant. The JIA‐ACR70 improvement by 16 weeks of treatment ranged from 11.3% to 89.5%. Compared with controls, significant JIA‐ACR70 improvements were observed for etanercept, golimumab, and all three combination therapies (adalimumab+MTX, etanercept+MTX, and infliximab+MTX), with odds ratios ranging from 2.97 to 3.99. No significant pairwise comparisons between bDMARDs and JAKi versus bDMARDs were noted.ConclusionOverall, no significant evidence was found for efficacy and safety profiles in pairwise comparisons of JAKis and bDMARDs. Future studies will expand the meta‐analysis by including non‐RCT studies and individual participant data.
Chronicity of Immune Checkpoint Inhibitor–Associated Inflammatory Arthritis After Immunotherapy Discontinuation: Results From the Canadian Research Group of Rheumatology in Immuno‐Oncology Database
Authors: Ladouceur Alexandra , Jamal Shahin , Saltman Alexandra , Himmel Megan , Hudson Marie , Pope Janet , Hoa Sabrina , Roberts Janet , Colmegna Inés , Arreola Lourdes Gonzalez , Nevskaya Tatiana , Karmali Ammana , Moon David , Schmidt Emma , Toban Nader , Cho Lindsay , Barnetche Thomas , Ye Carrie 
Published: February 2025

ObjectiveImmune checkpoint inhibitors (ICIs) improve overall survival (OS) and progression‐free survival (PFS) in many types of malignancies but can result in off‐target immune‐related adverse events including inflammatory arthritis (ICI‐associated inflammatory arthritis [ICI‐IA]), which can persist even after ICI cessation. We aimed to examine the proportion of patients with ICI‐IA who develop chronic ICI‐IA and describe characteristics and outcomes associated with chronic ICI‐IA.MethodsWe identified patients from the Canadian Research Group of Rheumatology in Immuno‐Oncology retrospective cohort who developed de novo ICI‐IA with at least three months of follow‐up after ICI cessation. Chronic ICI‐IA was defined as symptoms or ongoing immunosuppression lasting beyond three months after ICI discontinuation. Acute ICI‐IA was defined as resolution of ICI‐IA symptoms and discontinuation of immunosuppression within three months of ICI discontinuation. OS and PFS were assessed with Kaplan–Meier curves. Landmark multivariable Cox proportional hazard models for OS and PFS were conducted.ResultsThe study cohort included 119 patients. A total of 15 patients (13%) had acute ICI‐IA, whereas 104 (87%) had chronic ICI‐IA. Patients with chronic ICI‐IA were more likely to be White and to have polyarthritis at presentation. After adjusting for age, sex, tumor type, stage of cancer, ICI‐IA treatment, and time from ICI initiation to ICI‐IA onset, patients with chronic ICI‐IA had greater PFS from ICI initiation (adjusted hazard ratio 0.27, 95% confidence interval 0.08–0.98; P = 0.046). Adjusted hazard ratio for OS was similar between those with acute versus chronic ICI‐IA.ConclusionICI‐IA frequently persists after ICI discontinuation. Chronic ICI‐IA is associated with improved PFS, but not OS, as compared to acute ICI‐IA.