bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniqueness in the life sciences: how did the elephant get its trunk?
Authors: Buskell Andrew , Currie Adrian 
Published: July 2021

AbstractResearchers in the life sciences often make uniqueness attributions; about branching events generating new species, the developmental processes generating novel traits and the distinctive cultural selection pressures faced by hominins. Yet since uniqueness implies non-recurrence, such attributions come freighted with epistemic consequences. Drawing on the work of Aviezer Tucker, we show that a common reaction to uniqueness attributions is pessimism: both about the strength of candidate explanations as well as the ability to even generate such explanations. Looking at two case studies—elephant trunks and human teaching—we develop a more optimistic account. As we argue, uniqueness attributions are revisable claims about the availability of several different kinds of comparators. Yet even as researchers investigate the availability of such comparators, they are able to mobilize complex sets of empirical and theoretical tools. Rather than hindering scientific investigation, then, we argue that uniqueness attributions often spur the generation of a range of epistemic goods.
SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer
Authors: Alfarsi Lutfi H. , El Ansari Rokaya , Craze Madeleine L. , Mohammed Omar J. , Masisi Brendah K. , Ellis Ian O. , Rakha Emad A. , Green Andrew R. 
Published: July 2021

Abstract
Purpose
Identification of effective biomarkers for the benefit of endocrine treatment and understanding the molecular pathways that contribute to the development of resistance are of crucial importance to the management of luminal breast cancer. The amino acid transporter SLC1A5 has emerging importance as a prognostic marker and potential therapeutic target in various types of cancer. This study aims to investigate its role in luminal breast cancer as a potential predictive marker for endocrine treatment.

Methods
SLC1A5 expression was assessed at the transcriptomic and proteomic levels in large, well-characterized cohorts of luminal breast cancer. The sensitivity to endocrine therapy after SLC1A5 knockdown was investigated in vitro, using MCF7 and MDA-MB-175 cell lines. Bioinformatic analyses were performed to study the interacting networks of SLC1A5 and to identify a key co-expressed gene with SLC1A5.

Results
Here, we showed that patients with tumors that highly expressed SLC1A5 associated with a high risk of relapse after endocrine treatment. In vitro, depletion of SLC1A5 increases the sensitivity of luminal breast cancer cells to tamoxifen. TALDO1 was identified as key co-expressed gene with SLC1A5, and in vitro knockdown of SLC1A5 showed reduction in TALDO1 expression. Indeed, TALDO1 was associated with poor clinical outcomes in patients who were subject to endocrine therapy.

Conclusion
These findings suggest that metabolic alterations, particularly the interaction between the key amino acid transporter SLC1A5 and metabolic enzyme TALDO1, could affect the sensitivity of endocrine therapy. This study demonstrated the prognostic value of both SLC1A5 and TALDO1 as biomarkers in luminal breast cancer.
The impact of hyperbaric oxygen therapy on late radiation toxicity and quality of life in breast cancer patients
Authors: Batenburg Marilot C. T. , Maarse Wies , van der Leij Femke , Baas Inge O. , Boonstra Onno , Lansdorp Nina , Doeksen Annemiek , van den Bongard Desiree H. J. G. , Verkooijen Helena M. 
Published: July 2021

Abstract
Purpose
To evaluate symptoms of late radiation toxicity, side effects, and quality of life in breast cancer patients treated with hyperbaric oxygen therapy (HBOT).

Methods
For this cohort study breast cancer patients treated with HBOT in 5 Dutch facilities were eligible for inclusion. Breast cancer patients with late radiation toxicity treated with ≥ 20 HBOT sessions from 2015 to 2019 were included. Breast and arm symptoms, pain, and quality of life were assessed by means of the EORTC QLQ-C30 and -BR23 before, immediately after, and 3 months after HBOT on a scale of 0–100. Determinants associated with persistent breast pain after HBOT were assessed.

Results
1005/1280 patients were included for analysis. Pain scores decreased significantly from 43.4 before HBOT to 29.7 after 3 months (p < 0.001). Breast symptoms decreased significantly from 44.6 at baseline to 28.9 at 3 months follow-up (p < 0.001) and arm symptoms decreased significantly from 38.2 at baseline to 27.4 at 3 months follow-up (p < 0.001). All quality of life domains improved at the end of HBOT and after 3 months follow-up in comparison to baseline scores. Most prevalent side effects of HBOT were myopia (any grade, n = 576, 57.3%) and mild barotrauma (n = 179, 17.8%). Moderate/severe side effects were reported in 3.2% (n = 32) of the patients. Active smoking during HBOT and shorter time (i.e., median 17.5 vs. 22.0 months) since radiotherapy were associated with persistent breast pain after HBOT.

Conclusion
Breast cancer patients with late radiation toxicity reported reduced pain, breast and arm symptoms, and improved quality of life following treatment with HBOT.
Southern Green Cultural Criminology and Environmental Crime Prevention: Representations of Nature Within Four Colombian Indigenous Communities
Authors: Goyes David Rodríguez , Abaibira Mireya Astroina , Baicué Pablo , Cuchimba Angie , Ñeñetofe Deisy Tatiana Ramos , Sollund Ragnhild , South Nigel , Wyatt Tanya 
Published: July 2021

AbstractThis exploratory study develops a “southern green cultural criminology” approach to the prevention of environmental harms and crimes. The main aim is to understand differing cultural representations of nature, including wildlife, present within four Colombian Indigenous communities to evaluate whether they encourage environmentally friendly human interactions with the natural world, and if so, how. The study draws on primary data gathered by the Indigenous authors (peer researchers) of this article via a set of interviews with representatives of these four communities. We argue that the cosmologies that these communities live by signal practical ways of achieving ecological justice and challenging anthropocentrism.
A System to Access Online Services with Minimal Personal Information Disclosure
Authors: Russo Antonia , Lax Gianluca , Dromard Baptiste , Mezred Menad 
Published: July 2021

AbstractThe General Data Protection Regulation highlights the principle of data minimization, which means that only data required to successfully accomplish a given task should be processed. In this paper, we propose a Blockchain-based scheme that allows users to have control over the personal data revealed when accessing a service. The proposed solution does not rely on sophisticated cryptographic primitives, provides mechanisms for revoking the authorization to access a service and for guessing the identity of a user only in cases of need, and is compliant with the recent eIDAS Regulation. We prove that the proposed scheme is secure and reaches the expected goal, and we present an Ethereum-based implementation to show the effectiveness of the proposed solution.
Singularly Perturbed Oscillators with Exponential Nonlinearities
Authors: Jelbart S. , Kristiansen K. U. , Szmolyan P. , Wechselberger M. 
Published: July 2021

AbstractSingular exponential nonlinearities of the form$$e^{h(x)\epsilon ^{-1}}$$eh(x)ϵ-1with$$\epsilon >0$$ϵ>0small occur in many different applications. These terms have essential singularities for$$\epsilon =0$$ϵ=0leading to very different behaviour depending on the sign ofh. In this paper, we consider two prototypical singularly perturbed oscillators with such exponential nonlinearities. We apply a suitable normalization for both systems such that the$$\epsilon \rightarrow 0$$ϵ→0limit is a piecewise smooth system. The convergence to this nonsmooth system is exponential due to the nonlinearities we study. By working on the two model systems we use a blow-up approach to demonstrate that this exponential convergence can be harmless in some cases while in other scenarios it can lead to further degeneracies. For our second model system, we deal with such degeneracies due to exponentially small terms by extending the space dimension, following the approach in Kristiansen (Nonlinearity 30(5): 2138–2184, 2017), and prove—for both systems—existence of (unique) limit cycles by perturbing away from singular cycles having desirable hyperbolicity properties.
Exploring the interactions between vulnerability, resilience and adaptation to extreme temperatures
Authors: Nunes Ana Raquel 
Published: July 2021

AbstractProposed ways of improving adaptation to climate change have most often been supported by narrowly framed and separate analysis. This article investigates how different levels of vulnerability and resilience interplay with adaptation to extreme temperatures, what is the nature of these relationships and whether lower vulnerability and higher resilience contribute to increased adaptation. This article explores the governance implications of a project that, unlike other, brings together vulnerability, resilience and adaptation assessments. The project has made significant advances in addressing the current deficit integrated assessments for shaping governance propositions. Such propositions argue that the diverse levels of vulnerability and resilience convey important bases for (1) targeting at-risk older individuals; (2) developing vulnerability reduction actions; (3) resilience building actions; and (4) understanding ‘success cases’ and learn from them for developing appropriate policy measures. Taken together, these propositions offer a social, psychological and health framework not simply for governing extreme temperatures but for governing responses to climate change at large.
CFD Investigations of Bath Dynamics in a Pilot-Scale TSL Furnace
Authors: Obiso D. , Reuter M. , Richter A. 
Published: July 2021

Abstract
The hydrodynamics of a Top Submerged Lance (TSL) slag bath are investigated here by means of Computational Fluid Dynamics (CFD) simulation. The object of the study is the pilot-scale furnace located at TU Bergakademie Freiberg, where air is injected beneath the slag bath with a top lance. The fluid dynamics system is evaluated at operating conditions, with experimentally measured slag physical properties and real flow rates. The numerical approach is based on the Volume Of Fluid (VOF) model, a front-tracking method that allows the interface to be geometrically reconstructed. Using a fine computational grid, the multiphase interactions are calculated with a high level of detail, revealing the mechanisms of bubble formation and bath dynamics. Two lance configurations are compared, with and without a swirler, and the effect on the hydrodynamics is discussed with regards to key features of the process, such as bubble dynamics, slag splashing, the interface area, rotational sloshing, and bath mixing. The model predicts bubble frequencies in the range of 2.5 to 3 Hz and captures rotational sloshing waves with half the frequencies of the bubble detachment. These results agree with real furnace data from the literature, proving the reliability of the computing model and adding value to the empirical understanding of the process, thanks to the direct observation of the resolved multiphase flow features. The comparative study indicates that the air swirler has an overall positive effect in addition to the proposed enhancement of lance cooling, with an increase in the bath mixing and a reduction in the splashing.
Reduction Kinetics of Fine Hematite Ore Particles in Suspension
Authors: Chen Zhiyuan , Zeilstra Christiaan , van der Stel Jan , Sietsma Jilt , Yang Yongxiang 
Published: July 2021

Abstract
Suspension reduction kinetics of hematite ore particles at 1710 K to 1785 K was described by the Johnson-Mehl-Avrami-Kolmogorov model with Avrami exponent of 1.405. The apparent activation energy is 105.5 kJ mol−1 with the rate determining step of nucleation and growth. The reduction degree of the hematite at the endpoint is a linear function of temperature and the logarithmic oxygen potential of the reacting gas. A peak function of reaction rate constant with particle size has been verified in this work, and the maximum value of the reaction rate is located at around 85 µm particle size. The influence of heat transfer on the reaction process has been evaluated. The results suggest that the heating-up process for large particles, 244 µm particles, for instance, cannot be ignored. It can retard the reaction rate compared to small particles. Normally, the reaction rate constant decreases linearly with the increase of ln[p(O2)] of the reacting gas mixture. However, 95 vol pct CO2 in the reacting gas can accelerate the reaction rate of thermal decomposition of hematite due to the emissivity of CO2 gas. It results in a higher reaction rate of 110 µm particles in 95 vol pct CO2-containing gas than that in other less CO2-containing gases.
Minimierende und maximierende Vernehmungstaktiken: Risiko falscher Geständnisse und sozialpsychologische Wirkmechanismen
Authors: Schneider Teresa , May Lennart 
Published: July 2021

ZusammenfassungEinzelberichte deuten auf die Verwendung von Vernehmungstaktiken in Deutschland hin, die die Schwere der Tat und die Konsequenzen eines Geständnisses herunterspielen (Minimierung) und die vorhandenen Beweise und die Schwere der Konsequenzen von bestreitenden Aussagen übertreiben (Maximierung). Forschungsarbeiten zeigen jedoch, dass solche Taktiken die Rate falscher Geständnisse erheblich erhöhen. Es wird im vorliegenden Beitrag argumentiert, dass Minimierungs- und Maximierungstaktiken darauf abzielen, eine Aussagemotivation bei Beschuldigten (Zwischenziel) herzustellen, die in eine Geständniserlangung übergehen soll (Hauptziel). Diese Annahme gründet auf einer vorgenommenen Systematisierung und Abgrenzung einzelner Vorgehensweisen dieser Taktiken. Außerdem erklärt der Beitrag kursorisch die sozialpsychologischen Wirkungsweisen dieser Taktiken auf Geständnisentscheidungen. Dies soll helfen, zukünftig Wirkungsweisen einzelner Vorgehensweisen differenzierter wissenschaftlich zu untersuchen, besser zu verstehen und theoretisch zu begründen.
Acetabular fractures in the elderly: modern challenges and the role of conservative management
Authors: Mohan Kunal , Broderick James M. , Raza Hasnain , O’Daly Brendan , Leonard Michael 
Published: July 2021

Abstract
Introduction
The incidence of acetabular fractures in the elderly population is ever increasing. While management of acetabular fractures in young patients following high-energy trauma is well described, treatment of the elderly patient subgroup is complex and requires a unique, individualized approach. A variety of treatment strategies including operative and non-operative approaches exists to manage this vulnerable patient group. Conservative management of acetabular fractures in the elderly continues to play an important role in treatment of both stable fracture patterns and those medically unfit for surgery.

Aim
This review assessing the current literature was undertaken with the purpose of summarising the challenges of management in this at-risk cohort as well as quantifying the role and outcomes following conservative management in the elderly.

Conclusion
Our recommendation is that conservative management of acetabular fractures in the elderly can be considered as a treatment option on a case-by-case basis accounting for patient, injury, and surgical factors. If it is to be pursued, we advise a multidisciplinary approach focused on early mobility, minimisation of risk and regular follow-up to optimise patient outcomes.
Evaluation of Microencapsulated Synbiotic Preparations Containing Lactobionic Acid
Authors: Goderska Kamila , Kozłowski Patryk 
Published: July 2021

AbstractThe aim of this paper was to assess the prebiotic properties of lactobionic acid in the human gastrointestinal model. Five different strains of probiotic, or potentially probiotic, bacteria were used in the microencapsulation process; these were Lactobacillus casei Shirota, Lactococcus lactis ATCC1, Lactobacillus fermentum, Bifidobacterium bifidum DSM 20456, and Bifidobacterium bifidum DSM 20082. Starch with a concentration of 4% (w/v) and a degree of substitution of 0.03 was used to produce the microcapsules. The alginian microcapsules we produced functioned as a protective barrier for the probiotic microorganisms closed in them, protecting them from adverse conditions in the human digestive tract. The microorganisms could thus survive the encapsulation process and the in vitro model digestion process while retaining the ability to produce biomass. Factors such as pH and time affect the solution of alginate microcapsules. The capsule solution began when a pH of 7.4 was reached; this corresponded to pH in the target probiotic site, an in vitro model of the colon. The capsules had completely dissolved after 24 h of digestion at a pH of 8. The addition of lactobionic acid stimulated the growth of probiotic and potentially probiotic bacteria, thus confirming its prebiotic properties.
Predicting Synaptic Connectivity for Large-Scale Microcircuit Simulations Using Snudda
Authors: Hjorth J. J. Johannes , Hellgren Kotaleski Jeanette , Kozlov Alexander 
Published: July 2021

AbstractSimulation of large-scale networks of neurons is an important approach to understanding and interpreting experimental data from healthy and diseased brains. Owing to the rapid development of simulation software and the accumulation of quantitative data of different neuronal types, it is possible to predict both computational and dynamical properties of local microcircuits in a ‘bottom-up’ manner. Simulated data from these models can be compared with experiments and ‘top-down’ modelling approaches, successively bridging the scales. Here we describe an open source pipeline, using the software Snudda, for predicting microcircuit connectivity and for setting up simulations using the NEURON simulation environment in a reproducible way. We also illustrate how to further ‘curate’ data on single neuron morphologies acquired from public databases. This model building pipeline was used to set up a first version of a full-scale cellular level model of mouse dorsal striatum. Model components from that work are here used to illustrate the different steps that are needed when modelling subcortical nuclei, such as the basal ganglia.
Anti-Luminous Mental States: Logical, Psychological and Epistemic Problems
Authors: González-Castán Óscar L. 
Published: July 2021

AbstractIn this paper I shall argue that Tim Williamson’s argument for the anti-luminosity of many mental states faces difficult logical, psychological and epistemological problems. From a logical point of view, his argument is correct. However, the contrary argument that says that the anti-luminosity thesis does not necessarily follow from it is also correct. This opens a sceptical scenario. Hence, if Williamson wants to convince us that we should rationally prefer his argument rather than the other, he needs to add considerations that are not merely logical. These are psychological and epistemological in nature. However, none of these considerations is convincing.
Part-optimized forming by spatially distributed vaporizing foil actuators
Authors: Hahn Marlon , Tekkaya A. Erman 
Published: July 2021

AbstractElectrically vaporizing foil actuators are employed as an innovative high speed sheet metal forming technology, which has the potential to lower tool costs. To reduce experimental try-outs, a predictive physics-based process design procedure is developed for the first time. It consists of a mathematical optimization utilizing numerical forming simulations followed by analytical computations for the forming-impulse generation through the rapid Joule heating of the foils. The proposed method is demonstrated for an exemplary steel sheet part. The resulting process design provides a part-specific impulse distribution, corresponding parallel actuator geometries, and the pulse generator’s charging energy, so that all process parameters are available before the first experiment. The experimental validation is then performed for the example part. Formed parts indicate that the introduced method yields a good starting point for actual testing, as it only requires adjustments in the form of a minor charging energy augmentation. This was expectable due to the conservative nature of the underlying modeling. The part geometry obtained with the most suitable charging energy is finally compared to the target geometry.
The Nine Cancer Frames: A Tool to Facilitate Critical Reading of Cancer-Related Information
Authors: Murray Craig , von Possel Nina , Lie Hanne C. , Breivik Jarle 
Published: July 2021

AbstractPeople’s ability to critically assess cancer-related information is essential from a preventional and therapeutic, as well as a general democratic perspective. Such cancer literacy is not just about acquiring factual knowledge. It also involves the ability to analyze how the information is contextualized—how cancer is framed. Previous research concerning the framing of cancer in public discourse is voluminous and penetrating but also fragmented and inaccessible to non-experts. In this study, we have developed an integrated and applicable tool for analyzing cancer discourse by systematically classifying distinctive ways of framing of the concept of cancer. Building on previous research and an inductive framing analysis of a broad range of public cancer discourse, systematically selected from British and Norwegian newspapers, we have characterized nine cancer frames: the biomedical, the environmental, the epidemiological, the personal, the sociopolitical, the economic, the antagonistic, the alternative, and the symbolic frame. This framing scheme may be applied to analyze cancer-related discourse across a plurality of themes and contexts. We also show how different frames combine to produce more complex messages, thereby revealing underlying patterns, strategies, and conflicts in cancer communication. In conclusion, this analytical tool enables critical reading of cancer-related information and may be especially useful in educational initiatives to advance health communication and public understanding of cancer.
Societal implications of a changing Arctic Ocean
Authors: Huntington Henry P. , Zagorsky Andrey , Kaltenborn Bjørn P. , Shin Hyoung Chul , Dawson Jackie , Lukin Maija , Dahl Parnuna Egede , Guo Peiqing , Thomas David N. 
Published: July 2021

AbstractThe Arctic Ocean is undergoing rapid change: sea ice is being lost, waters are warming, coastlines are eroding, species are moving into new areas, and more. This paper explores the many ways that a changing Arctic Ocean affects societies in the Arctic and around the world. In the Arctic, Indigenous Peoples are again seeing their food security threatened and cultural continuity in danger of disruption. Resource development is increasing as is interest in tourism and possibilities for trans-Arctic maritime trade, creating new opportunities and also new stresses. Beyond the Arctic, changes in sea ice affect mid-latitude weather, and Arctic economic opportunities may re-shape commodities and transportation markets. Rising interest in the Arctic is also raising geopolitical tensions about the region. What happens next depends in large part on the choices made within and beyond the Arctic concerning global climate change and industrial policies and Arctic ecosystems and cultures.