bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application
Authors: Zhao Yunyu , Yan Zhipeng , Liu Ying , Zhang Yue , Shi Jie , Li Jingtao , Ji Fanpu 
Published: August 2021

AbstractPulmonary fibrosis (PF) is a chronic, progressive, fibrotic interstitial disease of the lung with poor prognosis and without effective treatment currently. Data from previous coronavirus infections, such as the Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome, as well as current clinical evidence from the Coronavirus disease 2019 (COVID-19), support that SARS-CoV-2 infection may lead to PF, seriously impacting patient prognosis and quality of life. Therefore, effective prevention and treatment of PF will improve patient prognosis and reduce the overall social and economic burdens. Stem cells, especially mesenchymal stem cells (MSCs) have many great advantages, including migration to damaged lung tissue and secretion of various paracrine factors, thereby regulating the permeability of endothelial and epithelial cells, reducing inflammatory response, promoting tissue repair and inhibiting bacterial growth. Clinical trials of MSCs for the treatment of acute lung injury, PF and severe and critically ill COVID-19 are ongoing. The purpose of this study is to systematically review preclinical studies, explored the effectiveness of MSCs in the treatment of bleomycin (BLM)-induced pulmonary fibrosis and analyze the potential mechanism, combined with clinical trials of current MSCs for idiopathic pulmonary fibrosis (IPF) and COVID-19, so as to provide support for clinical research and transformation of MSCs. Searching PubMed and Embase (− 2021.4) identified a total of 36 preclinical studies of MSCs as treatment of BLM-induced acute lung injury and PF in rodent models. Most of the studies showed the MSCs treatment to reduce BLM-induced lung tissue inflammatory response, inflammatory cell infiltration, inflammatory cytokine expression, extracellular matrix production and collagen deposition, and to improve Ashcroft score. The results of present studies indicate that MSCs may serve as a potential therapeutic modality for the treatment of PF, including viral-induced PF and IPF.
Generalized fuzzy GV-Hausdorff distance in GFGV-fractal spaces with application in integral equation
Authors: Alihajimohammad Alireza , Saadati Reza 
Published: August 2021

AbstractWe propose a method for constructing a generalized fuzzy Hausdorff distance on the set of the nonempty compact subsets of a given generalized fuzzy metric space in the sence of George–Veeramni and Tian–Ha–Tian. Next, we define the generalized fuzzy fractal spaces. Morever, we obtain a fixed point theorem of a class of generalized fuzzy contractions and present an application in integranl equation.
Inequalities for generalized Riemann–Liouville fractional integrals of generalized strongly convex functions
Authors: Farid Ghulam , Kwun Young Chel , Yasmeen Hafsa , Akkurt Abdullah , Kang Shin Min 
Published: August 2021

AbstractSome new integral inequalities for strongly $(\alpha ,h-m)$
(
α
,
h
−
m
)
-convex functions via generalized Riemann–Liouville fractional integrals are established. The outcomes of this paper provide refinements of some fractional integral inequalities for strongly convex, strongly m-convex, strongly $(\alpha ,m)$
(
α
,
m
)
-convex, and strongly $(h-m)$
(
h
−
m
)
-convex functions. Also, the refinements of error estimations of these inequalities are obtained by using two fractional integral identities. Moreover, using a parameter substitution and a constant multiplier, k-fractional versions of established inequalities are also given.
Epidemiological characterization of imported recurrent Plasmodium vivax and Plasmodium ovale in China, 2013–2020
Authors: Cui Yanwen , Zhang Li , Xia Zhigui , Zhou Hejun , Huang Fang 
Published: August 2021

Abstract
Background
China has reached important milestones in the elimination of malaria. However, the numbers of imported recurrent cases of Plasmodium vivax and P. ovale are gradually increasing, which increases the risk of malaria re-establishment in locations where Anopheles mosquitoes exist. The aim of this study is to characterize the epidemiological profiles of imported recurrent P. vivax and P. ovale cases, quantifying the recurrence burden and guiding the development of appropriate public health intervention strategies.

Methods
Individual-level data of imported recurrent P. vivax and P. ovale cases were collected from 2013 to 2020 in China via the Parasitic Diseases Information Reporting Management System. Demographic characteristics, temporal and spatial distributions, and the interval from previous infection to recurrence were analyzed by SAS, ArcGIS and GraphPad Prism software, respectively, to explore the epidemiological profiles of imported recurrent cases.

Results
A total of 307 imported recurrent cases, including 179 P. vivax and 128 P. ovale cases, were recorded. The majority of cases occurred in males (P. vivax 91.1%, P. ovale 93.8%) and migrant workers (P. vivax 43.2%, P. ovale 44.7%). Individuals aged 30–39 years had the highest P. vivax and P. ovale recurrent infection rates, respectively. The number of imported recurrent cases of infection by these two malaria species increased from 2013 to 2018, and P. vivax infection showed well-defined seasonality, with two peaks in February and June, respectively. More than 90% of patients with recurrent cases did not receive radical treatment for previous infection. Most imported recurrent P. vivax cases were reported in Yunnan Province and were imported from Myanmar, Ethiopia, and Pakistan, while most recurrent P. ovale cases were reported in southern China and primarily imported from Cameroon, Ghana, and Nigeria. The intervals from previous malaria infection to recurrence among different continents were significantly different (P = 0.0016) for P. vivax malaria but not for P. ovale malaria (P = 0.2373).

Conclusions
The large number of imported recurrent cases has been a major challenge in the prevention of malaria re-establishment in China. This study provides evidence to guide the development of appropriate public health intervention strategies for imported recurrent P. vivax and P. ovale cases.

Graphic abstract
Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease
Authors: Vandendriessche Charysse , Balusu Sriram , Van Cauwenberghe Caroline , Brkic Marjana , Pauwels Marie , Plehiers Nele , Bruggeman Arnout , Dujardin Pieter , Van Imschoot Griet , Van Wonterghem Elien , Hendrix An , Baeke Femke , De Rycke Riet , Gevaert Kris , Vandenbroucke Roosmarijn E. 
Published: August 2021

AbstractIncreasing evidence indicates that extracellular vesicles (EVs) play an important role in the pathogenesis of Alzheimer’s disease (AD). We previously reported that the blood–cerebrospinal fluid (CSF) interface, formed by the choroid plexus epithelial (CPE) cells, releases an increased amount of EVs into the CSF in response to peripheral inflammation. Here, we studied the importance of CP-mediated EV release in AD pathogenesis. We observed increased EV levels in the CSF of young transgenic APP/PS1 mice which correlated with high amyloid beta (Aβ) CSF levels at this age. The intracerebroventricular (icv) injection of Aβ oligomers (AβO) in wild-type mice revealed a significant increase of EVs in the CSF, signifying that the presence of CSF-AβO is sufficient to induce increased EV secretion. Using in vivo, in vitro and ex vivo approaches, we identified the CP as a major source of the CSF-EVs. Interestingly, AβO-induced, CP-derived EVs induced pro-inflammatory effects in mixed cortical cultures. Proteome analysis of these EVs revealed the presence of several pro-inflammatory proteins, including the complement protein C3. Strikingly, inhibition of EV production using GW4869 resulted in protection against acute AβO-induced cognitive decline. Further research into the underlying mechanisms of this EV secretion might open up novel therapeutic strategies to impact the pathogenesis and progression of AD.
Age-stage, two-sex life table analysis of Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae) reared on maize and kidney bean
Authors: Xie Wen , Zhi Junrui , Ye Jiaqin , Zhou Yeming , Li Cao , Liang Yujian , Yue Wenbo , Li Dingyin , Zeng Guang , Hu Chaoxing 
Published: August 2021

Abstract
Background
Spodoptera frugiperda (JE Smith), or fall armyworm, is one of major migratory agricultural pests with a wide range of hosts. The effect of different hosts (maize and kidney bean) on the growth and reproduction of S. frugiperda were investigated using the age-stage, two-sex life table method.

Results
The results showed that S. frugiperda could complete its entire life cycle on both hosts, albeit with significantly different development and reproduction. The durations of larval and pupal development were significantly prolonged whereas adult lifespan was shortened on kidney bean compared to maize. The differences of survival rates at each instar, prepupal and pupal stages between the two hosts were not statistically significant. The total pre-oviposition period was longer on kidney bean than that on maize (42.05 vs 39.04 days), but there was no difference in the oviposition rate (64.77 on kidney bean vs 62.48 on maize). The differences of net reproductive rate, intrinsic rate of increase and finite rate of increase were nonsignificant, while the mean generation time on kidney bean (42.05 days) was significantly longer than that on maize (40.92 days).

Conclusions
The results indicate that S. frugiperda can grow and reproduce normally on both hosts, although maize is more suitable. Nonetheless, the data show that this pest is harmful when the population density is high or when the preferred host is scarce.

Graphic abstract
Paclitaxel and mortality in patients with claudication and de novo femoropopliteal lesions: a historical cohort study
Authors: Gahide Gérald , Phaneuf Samuel C. , Cossette Mathilde , Banine Amine , Budimir Martina , Maghsoudloo Kourosh , Fei Phillip , Dou Bo Yi , Bouthillier Maxime , Alain Charles , Bradette Simon , Noel-Lamy Maxime , Belzile Francois , Bui Bao The , Despatis Marc Antoine , Vendrell Jean Francois 
Published: August 2021

Abstract
Objective
To compare the mortality rates of patients with claudication and de novo femoropopliteal lesions treated with and without paclitaxel coated devices (PCD).

Background
A recent meta-analysis, mostly including patients with claudication and de novo femoropopliteal lesions but also with recurrent stenoses and critical limb ischemia, has shown a significant excess mortality in patients treated with PCD.

Methods
Comparison of two historical cohorts of patients presenting with claudication and de novo femoropopliteal lesions treated with and without PCD between 2008 and 2018.

Results
After review of 5219 arteriograms in patients presenting with peripheral artery disease, 700 consecutive patients were included consisting in 72.6% of male (n = 508). Mean age was 68.1 ± 8.5 years. 45.7% of the patients (n = 320) had a treatment including a PCD. Mean femoropopliteal lesion length was 123 ± 91 mm including 44.6% of occlusions. Patients of the control group were censored at crossover to paclitaxel when applicable. Mortality rates at 1, 2 and 5 years were 4.6%, 7.5%, 19.4% and 1.6%, 6.2%, 16.6% in the non-PCD and PCD groups respectively. The relative risks of death when using PCD were 0.35 (p = 0.03), 0.83 (p = NS) and 0.86 (p = NS) at 1, 2 and 5 years respectively.

Conclusion
There was no excess mortality in patients with claudication and de novo femoropopliteal lesions treated with paclitaxel coated devices at 1, 2 and 5 years of follow-up in this cohort. The current study suggests that additional prospective randomized studies properly powered to study mortality are necessary.
Profiles of patients’ self-reported health after acute stroke
Authors: Rimmele D. Leander , Schrage Theresa , Lebherz Lisa , Kriston Levente , Gerloff Christian , Härter Martin , Thomalla Götz 
Published: August 2021

Abstract
Background
We aimed to identify groups of patients with similar health status after stroke, assessed by patient reported outcome measures (PROMs), to improve initial risk stratification.

Methods
In a prospective study, inpatients were recruited during acute stroke treatment. Demographics, history, and cardio-vascular risk factors were assessed at baseline. Self-reported functional status, physical and mental health as well as anxiety and depressive symptoms were assessed 3 and 12 months after stroke and used to identify latent classes. The association of patient characteristics with latent class membership was investigated with multinomial logistic regression.

Results
Of the 650 patients included with a mean age of 75 years and 48% female, 70% had ischemic, 6% hemorrhagic strokes, and 24% transient ischemic attacks. Median NIHSS on admission was 2 (IQR:0,5). Values of PROMs remained comparable at 3 and 12 months. A three-class model was developed, differentiating between patients with mildly (75%), moderately (17%), and severely (8%) impaired self-reported health status. Adjusted for univariately significant baseline characteristics, initial NIHSS distinguished mild- from moderate-, and moderate- from severe-class-membership (p < 0.001). Length of inpatient stay (p < 0.001;OR = 1.1), diabetes (p = 0.021;OR = 1.91), and atrial fibrillation (p = 0.004;OR = 2.20) predicted allocation to the moderately vs. mildly affected class.

Conclusions
Grading stroke patients by a standard set of PROMs up to 1 year after stroke allows to distinguish the diverse impact of baseline characteristics on differently affected groups. In addition to initial stroke severity, longer inpatient stay, presence of diabetes and atrial fibrillation correlate with greater impairment of self-reported health in the less affected groups.

Trial registration
http://www.ClinicalTrials.gov; Unique identifier: NCT03795948.
Recover the abnormal positioning, velocity and timing services caused by BDS satellite orbital maneuvers
Authors: Tu Rui , Zhang Rui , Zhang Pengfei , Han Junqiang , Fan Lihong , Lu Xiaochun 
Published: August 2021

AbstractThe BeiDou Navigation Satellite System (BDS) provides global Positioning, Velocity, And Timing (PVT) services that are widely used in various areas. The BDS satellites frequently need the orbit maneuvers due to various perturbations to keep satellites in their designed positions. During these maneuvers, PVT services may be abnormal if the data from a maneuvering satellite is used. In this paper we developed an approach to recover the abnormal PVT services. By using BDS observations from multiple tracking stations, the orbital errors of a maneuvering satellite can be in real time obtained and corrected, thereby avoiding any influence on the performance of PVT services. The tests show that the average precision of position, velocity and timing services are improved by 0.8 m, 0.1 mm/s and 0.16 ns, respectively, using the developed orbital maneuver recovery approach. In addition, the approach can also be used for the orbital maneuver detection and monitoring.
‘Soother of mind’ – meditation in psychiatric disorders: a narrative review
Authors: Kumar Vinod , Bhide Shree Raksha , Arasappa Rashmi , Varambally Shivarama , Gangadhar Bangalore N. 
Published: August 2021

SUMMARYMeditation, a component of ashtanga yoga, is an act of inward contemplation in which the mind fluctuates between a state of attention to a stimulus and complete absorption in it. Some forms of meditation have been found to be useful for people with psychiatric conditions such as anxiety, depression and substance use disorder. Evidence for usefulness of meditation for people with psychotic disorders is mixed, with reported improvements in negative symptoms but the emergence/precipitation of psychotic symptoms. This article narrates the benefits of meditation in psychiatric disorders, understanding meditation from the yoga perspective, biological aspects of meditation and practical tips for the practice of meditation. We also explain possible ways of modifying meditative practices to make them safe and useful for the patient population and useful overall as a society-level intervention.
Oncocytic Adrenocortical Carcinoma With Low 18F-FDG Uptake and the Absence of Glucose Transporter 1 Expression
Authors: Babaya Naru , Noso Shinsuke , Hiromine Yoshihisa , Taketomo Yasunori , Niwano Fumimaru , Monobe Keisuke , Imamura Shuzo , Ueda Kazuki , Yamazaki Yuto , Sasano Hironobu , Ikegami Hiroshi 
Published: August 2021

Abstract
Adrenocortical carcinoma (ACC) is a rare tumor, and some histological variants (oncocytic, myxoid, and sarcomatoid ACCs) have been reported in addition to the conventional ACC. Among these subtypes, oncocytic ACC is histologically characterized by the presence of abundant eosinophilic granular cytoplasm in the carcinoma cells owing to the accumulation of mitochondria, which generally yields high 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET). Herein, we report the case of a 21-year-old woman with oncocytic ACC with low FDG uptake on PET scan. Her circulating levels of androgens were high, and androgen-synthesis enzymes were detected in carcinoma cells. The patient also had hypocholesterolemia. However, glucose transporter 1 (GLUT1) was not detected in the tumor, which was considered to account for the low FDG uptake by the tumor. To the best of our knowledge, this is the first case of low FDG uptake by oncocytic ACC without GLUT1 expression. Additionally, since hypocholesterolemia was reported in 3 previous reports of androgen-producing tumors, a possible correlation between androgenicity in adrenal tumors and the development of hypocholesterolemia could be postulated; however, further investigations are needed for clarification. This case highlights important information regarding the diversity of ACC and its impact on hypocholesterolemia.
Identifying and Supporting the Needs of Internal Medicine and Pediatrics Residents Interested in Pediatric Hospital Medicine Fellowship
Authors: Boggs Elizabeth , Luttrell Harrison , Basco William , Brittan Mark , Jerardi Karen , Kessenich Jeri , Kondos Valien , O'Toole Jennifer , Solomon Jeffrey , Tarchichi Tony , Jenkins Ashley 
Published: August 2021

BACKGROUNDPediatric hospital medicine (PHM) became a subspecialty of the American Board of Pediatrics (ABP) in 2016. Starting in 2019, residency graduates are required to complete fellowship training to qualify for PHM board eligibility. These requirements pose unique challenges to internal medicine–pediatrics (med‐peds) residents interested in practicing combined adult hospital medicine (HM) and PHM.OBJECTIVETo describe the needs of med‐peds residents interested in PHM fellowship training and how the current PHM training environment can meet these needs.METHODSWe conducted two cross‐sectional electronic survey studies: one of med‐peds residents and one of PHM fellowship program directors (FDs). Surveys were distributed to resident and FD listservs. Questions were designed using an iterative consensus process among authors. Responses were analyzed with descriptive statistics.RESULTSFour hundred sixty‐six residents responded to the resident survey. Ninety‐six percent (n = 446) had considered a career in HM. Almost all (n = 456, 97.9%) respondents indicated a preference for a fellowship with both adult HM and PHM clinical training. Subspecialty designation decreased desire to pursue a career including PHM for 90.1% of respondents. Twenty‐eight (58.3%) FDs responded to the FD survey. Fifteen (53.6%) programs reported being able to accommodate adult HM and PHM clinical time.CONCLUSIONThe majority of resident respondents reported a desire for a PHM fellowship with clinical time in both PHM and adult HM. Approximately 30% of current US PHM fellowship programs can accommodate adult HM practice for med‐peds fellows, and many other programs would be willing to explore such opportunities.
An Initiative to Improve 30‐Day Readmission Rates Using a Transitions‐of‐Care Clinic Among a Mixed Urban and Rural Veteran Population
Authors: Griffin Benjamin R , Agarwal Neeru , Amberker Rachana , Perez Jeydith A Gutierrez , Eichorst Kelsi , Chapin Jennifer , Schweitzer Amy C , Hagiwara Mariko , Wu Chaorong , Eyck Patrick Ten , Reisinger Heather Schacht , Vaughan‐Sarrazin Mary , Kuperman Ethan F , Glenn Kevin , Jalal Diana I 
Published: August 2021

BACKGROUND/OBJECTIVEHospital readmissions in the United States, especially in patients at high‐risk, cost more than $17 billion annually. Although care transitions is an important area of research, data are limited regarding its efficacy, especially among rural patients. In this study, we describe a novel transitions‐of‐care clinic (TOCC) to reduce 30‐day readmissions in a Veterans Health Administration setting that serves a high proportion of rural veterans.METHODSIn this quality improvement initiative we conducted a pre‐post study evaluating clinical outcomes in adult patients at high risk for 30‐day readmission (Care Assessment Needs score > 85) discharged from the Iowa City Veterans Affairs (ICVA) Health Care System from 2017 to 2020. The ICVA serves 184,000 veterans across 50 counties in eastern Iowa, western Illinois, and northern Missouri, with more than 60% of these patients residing in rural areas. We implemented a multidisciplinary TOCC to provide in‐person or virtual follow‐up to high‐risk veterans after hospital discharge. The main purpose of this study was to assess how TOCC follow‐up impacted the monthly 30‐day patient readmission rate.RESULTSThe TOCC resulted in a 19.2% relative reduction in 30‐day readmission rates in the 12‐month postimplementation period compared to the preimplementation period (9.2% vs 11.4%, P = .04). Virtual visits were more popular than in‐person visits among both urban and rural veterans. There was no difference in outcomes between these two follow‐up options, and both groups had reduced readmission rates compared to non‐TOCC follow‐up.CONCLUSIONSA multidisciplinary TOCC within the ICVA featuring both virtual and in‐person visits reduced the 30‐day readmission rate. This reduction was particularly notable among patients with congestive heart failure. Journal of Hospital Medicine 2021;16:583‐588.
VIDA DE MARIA EM TERRAS DE MARIANO: MARIA, A PRIMEIRA MULHER NEGRA A CONCLUIR O PROEJA NO COLÉGIO TÉCNICO INDUSTRIAL DE SANTA MARIA (CTISM).
Authors: Budiño Nara Zari Lemos , Pommer Roselene M Gomes 
Published: August 2021

O presente artigo faz parte da dissertação de mestrado apresentada ao Programa de Pós-graduação em Educação Profissional e Tecnológica da Universidade Federal de Santa Maria-RS, que teve por título “Ações Afirmativas para a educação profissional e tecnológica: Negros e Negras no Colégio Técnico e Industrial de Santa Maria”. Analisamos os Ciclos de Estudos sobre História e Culturas Afro-brasileira que ocorrem no CTISM desde 2010. No artigo em questão analisamos a trajetória de uma partir de uma mulher negra, pobre e periférica, aluna do CTISM. Nossa fonte de pesquisa foi um documentário institucional, produzido em 2015, pelos alunos do Colégio Técnico Industrial de Santa Maria para o Ciclo de Estudos sobre História e Culturas Afro-brasileira. Como mote do trabalho analisamos a importância de uma educação onmilateral para enfrentar a luta de classes, bem como as contradições impostas à nossa personagem em uma sociedade machista e racista.