bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eruptive Seborrheic Keratoses Are Associated With a Co-Occurring Malignancy in the Majority of Reported Cases: A Systematic Review
Authors: Mirali Sara , Mufti Asfandyar , Lansang Rafael Paolo , Sachdeva Muskaan , Yeung Jensen 
Published: November 2021

Background Eruptive seborrheic keratoses (ESK) is a benign skin condition that has been associated with malignant and nonmalignant diseases. We conducted a systematic review of reported cases of ESK to identify and summarize associated comorbidities. Methods MEDLINE and Embase were searched from database inception (1946) to July 31, 2020 for original articles describing ESK with or without a co-occurring condition. Subject demographics, as well as details of ESK and associated diagnoses were extracted from 76 articles (70 case reports, 3 case series, 3 case control studies) representing 92 patients. Results In total, 76.1% ( n = 70/92) of patients with ESK had a co-occurring malignancy, 4.3% ( n = 4/92) presented with a nonmalignant condition, 9.8% ( n = 9/92) experienced ESK as an adverse drug reaction, and 9.8% ( n = 9/92) did not report any underlying medical condition. ESK preceded a cancer diagnosis in 76.1% ( n = 70/92) of patients with a mean latency period of 4.0 months (range: 0.25-9 months). The most common malignancies associated with ESK were cutaneous T-cell lymphoma ( n = 10/70, 14.3%) and gastrointestinal adenocarcinoma ( n = 9/70, 12.9%). ESK preceded nonmalignant conditions or no disease in 14.1% ( n = 13/92) of patients with a mean latency period of 3.1 months (range: 0.75-6 months). Drug-induced ESK occurred in 9.8% ( n = 9/92) of patients with a mean latency period of 7.1 weeks after changing medication. Conclusion Although the role of ESK as a paraneoplastic cutaneous marker is debated, healthcare providers should consider screening for underlying malignancy in patients presenting with ESK. Larger studies are needed to confirm its role as a marker for disease.
Measuring the effect of gender segregation on the gender gap in time-related underemployment
Authors: Acosta-Ballesteros Juan , Osorno-del Rosal María del Pilar , Rodríguez-Rodríguez Olga María 
Published: November 2021

AbstractThis paper focuses on the impact that gender segregation in the labour market exerts on the underemployment gender gap for young adult workers in Spain. In order to analyse the relative importance of segregation in this gap, we develop a methodology based on two counterfactual simulations that provides a detailed decomposition of the gap into endowments and coefficients effects as well as the interaction of these effects. To the best of our knowledge, we are the first to perform a decomposition using bivariate probit models with sample selection. Using annual samples of the Spanish Labour Force Survey 2006–2016, the results show that working in female-dominated occupations or industries hinders working as many hours as desired, especially for women. Furthermore, we conclude that the gender gap in underemployment is mainly due to the different distribution of male and female workers across occupations and industries. Additionally, the different impact by gender that working in the same gender-typing jobs exerts on the risk of underemployment contributes to widening the gap.
Expression of transport proteins in the rete mirabile of european silver and yellow eel
Authors: Schneebauer Gabriel , Drechsel Victoria , Dirks Ron , Faserl Klaus , Sarg Bettina , Pelster Bernd 
Published: December 2021

Abstract
Background
In physoclist fishes filling of the swimbladder requires acid secretion of gas gland cells to switch on the Root effect and subsequent countercurrent concentration of the initial gas partial pressure increase by back-diffusion of gas molecules in the rete mirabile. It is generally assumed that the rete mirabile functions as a passive exchanger, but a detailed analysis of lactate and water movements in the rete mirabile of the eel revealed that lactate is diffusing back in the rete. In the present study we therefore test the hypothesis that expression of transport proteins in rete capillaries allows for back-diffusion of ions and metabolites, which would support the countercurrent concentrating capacity of the rete mirabile. It is also assumed that in silver eels, the migratory stage of the eel, the expression of transport proteins would be enhanced.

Results
Analysis of the transcriptome and of the proteome of rete mirabile tissue of the European eel revealed the expression of a large number of membrane ion and metabolite transport proteins, including monocarboxylate and glucose transport proteins. In addition, ion channel proteins, Ca2+-ATPase, Na+/K+-ATPase and also F1F0-ATP synthase were detected. In contrast to our expectation in silver eels the expression of these transport proteins was not elevated as compared to yellow eels. A remarkable number of enzymes degrading reactive oxygen species (ROS) was detected in rete capillaries.

Conclusions
Our results reveal the expression of a large number of transport proteins in rete capillaries, so that the back diffusion of ions and metabolites, in particular lactate, may significantly enhance the countercurrent concentrating ability of the rete. Metabolic pathways allowing for aerobic generation of ATP supporting secondary active transport mechanisms are established. Rete tissue appears to be equipped with a high ROS defense capacity, preventing damage of the tissue due to the high oxygen partial pressures generated in the countercurrent system.
A rare case of a male child with post-zygotic de novo mosaic variant c.538C > T in MECP2 gene: a case report of Rett syndrome
Authors: Shah Jhanvi , Patel Harsh , Jain Deepika , Sheth Frenny , Sheth Harsh 
Published: December 2021

Abstract
Background
Rett syndrome (RTT) is characterized by a normal perinatal period with a normal head size at birth followed by normal development for the first 6 months of life followed by gradual deceleration of head growth, loss of acquired purposeful hand skills, severe expressive and receptive language impairment, severe intellectual disability and gait and truncal apraxia/ ataxia. It is caused due to mutations in the MECP2 gene and follows an X-linked dominant mode of inheritance. It was observed exclusively in females and was believed to be lethal in males. In contrast to this belief, several males were identified with RTT upon genetic analysis, however, most males expired by the age of 2 years due to neonatal encephalopathy. The ones that survived beyond the age of 2 years, were attributed to the presence of an extra X chromosome (co-occurrence of Klinefelter and RTT) or the ones having mosaic cell lines. Only 11 males with somatic mosaicism are known till date.

Case presentation
This case reports an ultra-rare case of a male affected with RTT surviving beyond the age of 2 years due to post-zygotic de novo somatic mosaicism. He was identified with a known pathogenic variant c.538C > T (p.R180*), which to the best of our knowledge is exclusively seen in females and has never been reported in a male before.

Conclusion
The present case is the first report of a mosaic male affected with RTT from India. The present report also carried out genotype-phenotype correlations across surviving mosaic males with RTT. We also postulate the effect of variant type, position along the gene and the variant allele fraction in different tissue types to be correlated with disease severity.
Understanding the complexity of sepsis mortality prediction via rule discovery and analysis: a pilot study
Authors: Wu Ying , Huang Shuai , Chang Xiangyu 
Published: November 2021

AbstractBackgroundSepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, has become one of the major causes of death in Intensive Care Units (ICUs). The heterogeneity and complexity of this syndrome lead to the absence of golden standards for its diagnosis, treatment, and prognosis. The early prediction of in-hospital mortality for sepsis patients is not only meaningful to medical decision making, but more importantly, relates to the well-being of patients.MethodsIn this paper, a rule discovery and analysis (rule-based) method is used to predict the in-hospital death events of 2021 ICU patients diagnosed with sepsis using the MIMIC-III database. The method mainly includes two phases: rule discovery phase and rule analysis phase. In the rule discovery phase, the RuleFit method is employed to mine multiple hidden rules which are capable to predict individual in-hospital death events. In the rule analysis phase, survival analysis and decomposition analysis are carried out to test and justify the risk prediction ability of these rules. Then by leveraging a subset of these rules, we establish a prediction model that is both more accurate at the in-hospital death prediction task and more interpretable than most comparable methods.ResultsIn our experiment, RuleFit generates 77 risk prediction rules, and the average area under the curve (AUC) of the prediction model based on 62 of these rules reaches 0.781 ($$\pm 0.018$$±0.018) which is comparable to or even better than the AUC of existing methods (i.e., commonly used medical scoring system and benchmark machine learning models). External validation of the prediction power of these 62 rules on another 1468 sepsis patients not included in MIMIC-III in ICU provides further supporting evidence for the superiority of the rule-based method. In addition, we discuss and explain in detail the rules with better risk prediction ability. Glasgow Coma Scale (GCS), serum potassium, and serum bilirubin are found to be the most important risk factors for predicting patient death.ConclusionOur study demonstrates that, with the rule-based method, we could not only make accurate prediction on in-hospital death events of sepsis patients, but also reveal the complex relationship between sepsis-related risk factors through the rules themselves, so as to improve our understanding of the complexity of sepsis as well as its population.
Long- and short-term clinical impact of awake extracorporeal membrane oxygenation as bridging therapy for lung transplantation
Authors: Kim Nam Eun , Woo Ala , Kim Song Yee , Leem Ah Young , Park Youngmok , Kwak Se Hyun , Yong Seung Hyun , Chung Kyungsoo , Park Moo Suk , Kim Young Sam , Kim Ha Eun , Lee Jin Gu , Paik Hyo Chae , Lee Su Hwan 
Published: November 2021

Abstract
Background
As lung transplantation (LTx) is becoming a standard treatment for end-stage lung disease, the use of bridging with extracorporeal membrane oxygenation (ECMO) is increasing. We examined the clinical impact of being awake during ECMO as bridging therapy in patients awaiting LTx.

Methods
In this single-center study, we retrospectively reviewed 241 consecutive LTx patients between October 2012 and March 2019; 64 patients received ECMO support while awaiting LTx. We divided into awake and non-awake groups and compared.

Results
Twenty-five patients (39.1%) were awake, and 39 (61.0%) were non-awake. The median age of awake patients was 59.0 (interquartile range, 52.5–63.0) years, and 80% of the group was men. The awake group had better post-operative outcomes than the non-awake group: statistically shorter post-operative intensive care unit length of stay [awake vs. non-awake, 6 (4–8.5) vs. 18 (11–36), p < 0.001], longer ventilator free days [awake vs. non-awake, 24 (17–26) vs. 0 (0–15), p < 0.001], and higher gait ability after LTx (awake vs. non-awake, 92% vs. 59%, p = 0.004), leading to higher 6-month and 1-year lung function (forced expiratory volume in 1 s: awake vs. non-awake, 6-month, 77.5% vs. 61%, p = 0.004, 1-year, 75% vs. 57%, p = 0.013). Furthermore, the awake group had significantly lower 6-month and 1-year mortality rates than the non-awake group (6-month 12% vs. 38.5%, p = 0.022, 1-year 24% vs. 53.8%, p = 0.018).

Conclusions
In patients with end-stage lung disease, considering the long-term and short-term impacts, the awake ECMO strategy could be useful compared with the non-awake ECMO strategy.
Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2
Authors: Ruiz Mario , Henricsson Marcus , Borén Jan , Pilon Marc 
Published: November 2021

Abstract
Background
AdipoR1 and AdipoR2 (AdipoRs) are plasma membrane proteins often considered to act as adiponectin receptors with a ceramidase activity. Additionally, the AdipoRs and their yeast and C. elegans orthologs are emerging as membrane homeostasis regulators that counter membrane rigidification by promoting fatty acid desaturation and incorporation of unsaturated fatty acids into phospholipids, thus restoring fluidity.

Methods
Using cultured cells, the effects of AdipoR silencing or over-expression on the levels and composition of several sphingolipid classes were examined.

Results
AdipoR2 silencing in the presence of exogenous palmitic acid potently causes increased levels of dihydroceramides, a ceramide precursor in the de novo ceramide synthesis pathway. Conversely, AdipoR2 over-expression caused a depletion of dihydroceramides.

Conclusions
The results are consistent with AdipoR2 silencing leading to increased intracellular supply of palmitic acid that in turn leads to increased dihydroceramide synthesis via the rate-limiting serine palmitoyl transferase step. In agreement with this model, inhibiting the desaturase SCD or SREBF1/2 (positive regulators of SCD) also causes a strong increase in dihydroceramide levels.
Anthropogenic disturbances consistently favor the high-yield strategists of soil bacterial community in the Eurasian steppe
Authors: Fan Yi , Li Tingting , Liu Wei , Xu Minjie , Pang Shuang , Zhang Zijia , Zhang Lihua , Son Yowhan , Zhang Ximei 
Published: November 2021

Abstract
Purpose
Multiple anthropogenic disturbances, such as climate warming and nitrogen deposition are affecting terrestrial ecosystems. Different disturbances may have some consistent effects on the soil microbial community, which remains largely unexplored.

Methods
We mimicked 16 anthropogenic disturbances in a steppe ecosystem, and measured the absolute abundance and taxonomic composition of soil bacterial communities with qPCR and amplicon sequencing, respectively.

Results
We found that while the absolute abundance of each of the four dominant bacterial phyla did not show a consistent response to these disturbances, that of the five subdominant phyla showed a consistent increase. Meanwhile, these disturbances consistently stimulated the relative abundances of metabolic functions for high-growth-yield, including the transport/metabolism of amino acids and carbohydrates. Stochastic processes (e.g., random birth) played more critical roles in structuring the subdominant than dominant phyla, and the disturbances promoted the stochastic processes.

Conclusions
Overall, the high-yield traits and stochasticity of subdominant phyla led to their positive responses to disturbances. Furthermore, our findings indicate that the intensifying human activities are likely to cause a high-yield-strategies-toward shift in soil microbial composition in the Eurasian steppe ecosystem.
Rhabdomyosarcoma of the uterus in an adult patient with osteopetrosis: a case report
Authors: Aminimoghaddam Soheila , Rahbari Ali , Pourali Roghayeh 
Published: November 2021

Abstract
Background
Uterine sarcoma accounts for 3–7% of uterine malignant neoplasms. It is more aggressive than epithelial neoplasms, and patients have a poor prognosis. Rhabdomyosarcoma is classified as a heterologous uterine sarcoma. It is the most common soft tissue malignancy in children while rare in adults. In young patients, the majority of genital tract rhabdomyosarcomas occur in vagina; however, the most common site of gynecologic rhabdomyosarcoma is cervix followed by uterine corpus, in adults. Uterine corpus rhabdomyosarcoma is rare in adults. Diagnosis of pure rhabdomyosarcoma in uterus involves widespread and perfect sampling as well as precise histopathological evaluation to uncover any epithelial component.

Case presentation
Here we report a case of pure rhabdomyosarcoma of uterine corpus in a 60-year-old Iranian postmenopausal female who had osteopetrosis, presenting with 8-month heavy vaginal bleeding and a protruding cervical mass. She is alive on 18-month follow-up after treatment.

Conclusions
Rhabdomyosarcoma of uterine corpus is rare in adults. Diagnosis of pure rhabdomyosarcoma in uterus involves widespread and perfect sampling as well as precise histopathological evaluation to uncover any epithelial component. Treatment options in adult gynecological rhabdomyosarcoma are based on studies in younger patients, and more studies may help us choose the best approach for improving outcome.
Pathogenicity of some local entomopathogenic fungus isolates on the cotton leafworm larvae, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae)
Authors: Şahin Funda , Yanar Yusuf 
Published: November 2021

Abstract
Background
Pathogenicity of the entomopathogenic fungi (EPF), isolated from soil samples collected from Ordu Province, Turkey, was evaluated on the second-instar larvae of the cotton leaf worm Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) under laboratory conditions.

Results
Firstly, single-concentration response tests were conducted in order to determine the efficacy of the 64 isolates on S. littoralis larvae at the concentration of 1 × 108 conidia/ml. The five isolates displaying the highest mortality rates in single-concentration response tests, ORU-50, ORM-40, ORP-13, ORP-27 and ORM-48 (which included Beauveria bassiana, Metarhizium brunneum and Clonostachys rogersoniana), were subjected to concentration–response tests at the concentrations of 1 × 105–1 × 109 conidia/ml. The lowest LC50 and LC90 values were recorded at ORP-27 with 1.68 × 107 and 4.60 × 108 conidia/ml, respectively, followed by ORP-13 and ORM-40.

Conclusions
Accordingly, it was found that M. brunneum isolates were more effective than B. bassiana and C. rogersoniana against S. littoralis larvae. ORP-27, ORP-13 and ORM-40 of M. brunneum isolates can be a potential biological control agent used against S. littoralis larvae.
Green product awareness effect on green purchase intentions of university students’: an emerging market’s perspective
Authors: Ansu-Mensah Peter 
Published: November 2021

AbstractThe indiscriminate consumption patterns worldwide have brought in its wake severe problems like pollution and global warming, and this has ultimately called for green products awareness and consumption. The main purpose of this study was to assess the effect of university students’ awareness of green products on their green purchasing intentions. The specific objectives were to identify whether awareness, price, availability, value and quality influence university students’ intention to purchase green products, and to investigate how awareness, price, availability, value and quality predict university students’ intention to purchase green products. A structural equation modeling was used to analyze data collected from an online survey of 478 students. Results show that green perceived quality has the utmost significant positive impact on university students’ green purchase intentions; however, green perceived availability had the slightest impact on university students’ intention to purchase green products. The study is the foremost to conclude that green product awareness impact on university students green purchase intentions is greatly driven by price, high value and extraordinary quality. However, availability is not a critical influencing factor when it comes to green purchase intentions of university students. The implications of study, limitations and further research are discussed.
Pemanfaatan Batubara Kalori Rendah pada IGCC (Integrated Gasification Combined Cycle)
Authors: Zaman Muhammad Rizaldi , Suedy Sri Widodo Agung 
Published: November 2021

Kekhawatiran akan emisi gas rumah kaca dan krisis energi yang semakin dirasakan negara-negara didunia khususnya di Indonesia menyebabkan perlu dilakukan pengembangan energi alternatif yang bersih dan ramah lingkungan. Teknologi Integrated Gasification Combined Cycle dapat menjadi alternatif terbaik untuk mengatasi permasalaan tersebut. Penelitian ini dilakukan dengan tujuan untuk memberikan gambaran dan keuntungan dari proses IGCC berdasarkan penilitian-penelitian yang sudah ada sehingga dapat dilakukan pengembangan pemanfaatan IGCC menggunakan batubara lignit di Indonesia. Penelitian ini dilakukan dengan studi literatur, pengumpulan data dilakukan dari penelitian-penelitian yang sudah ada untuk mengetahui dampak dan metode yang digunakan untuk mengeringkan batubara rendah yang memiliki moisture tinggi. Analisis dalam penelitian dilakukan menggunakan perbandingan dari setiap literatur, sehingga diperoleh proses dan teknologi yang sesuai untuk pemanfaatan IGCC. Hasil penelitian menunjukkan pemanfaatan teknologi IGCC menggunakan batubara lignit sangat menjanjikan karena walaupun lignit memiliki keterbatasan dalam efisiensi termal karena moisture bahan bakar yang sangat tinggi namun hal ini bisa diminimalisir menggunakan proses drying. Jumlah batubara lignit yang melimpah di Indonesia dapat memudahkan pengembangan IGCC dan emisi yang dihasilkan lebih rendah daripada pembangkit fosil lainnya.
HAND IN HAND WITH TIMOR EXCHANGE
Authors: Anabela Anabela Moura 
Published: November 2021

Hand in hand with Timor (De mãos dadas com Timor) is a project that explores cultural competencies, social interaction through the Arts and Communication which has promoted cognitive development and a systematic contact between participants from very diverse cultural contexts (Portuguese students in two classes of the 1st year Basic Education Teacher Training BA Degree at the Higher School of Education of Viana do Castelo Polytechnic [ESEVC-IPVC], attending the subject entitled Theories and Practices of Visual and Performing Arts, and Timor children, teachers and educators working in the Pre-School level of Education at the Portuguese School of Dili - CELP - Ruy Cinatti, Timor). This international exchange arose from contacts made between the teacher of Visual Arts at ESEVC-IPVC and Flor Gomes, former student of ESEVC-IPVC, with a BA degree in Visual and Technological Education and a Master in Art Education at ESEVC-IPVC, teacher in statutory mobility, currently working in Timor between 2020 and 2022. This article, written by two researchers from the Art Education area, addresses a Portuguese project which emphasised an action-research underpinned in an interdisciplinary approach, using comics as teaching strategy in developing cultural competencies of eighty Portuguese students (nº=80) of a Basic Education Course. The findings of such collaboration using video as the communication support for this international exchange, show the positive effects of such Project that promoted the overall cultural and artistic competencies of students involved, either in Portugal or in Timor. It is concluded that such curricular experiment had on students, on their motivation and awareness of how illustration and video can work together with popular literature, staging and illustrating it. It also highlights how imagination, creativity, dialogue and cultural competencies of children can promote a deeply collaborative work at local, regional, national and international levels, despite the fact that we are living in a period of pandemic and confinement.