bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunologische Merkmale und Faktoren im Zusammenhang mit dem mukokutanen bullösen Pemphigoid – eine retrospektive Kohortenstudie
Authors: Ständer Sascha , Schmidt Enno , Zillikens Detlef , Ludwig Ralf J. , Kridin Khalaf 
Published: September 2021

ZusammenfassungHintergrund und ZieleDie besonderen Charakteristika von Patienten mit bullösem Pemphigoid (BP) mit Schleimhautbeteiligung sind weitgehend unbekannt. Unser Ziel war die Erforschung der klinischen und immunologische Charakteristika von BP‐Patienten mit Schleimhautbeteiligung, um Faktoren zu identifizieren, die mit Schleimhautläsionen assoziiert sind.Patienten und MethodikEine retrospektive Studie, die alle konsekutiven Patienten umfasst, die in den Jahren 2009–2019 in einem tertiären Referenzzentrum mit BP diagnostiziert wurden.ErgebnisseDie Studie umfasste 273 Patienten mit BP, von denen 31 (11,4 %) Schleimhautläsionen aufwiesen. Die Mundschleimhaut war die am häufigsten betroffene Schleimhautoberfläche (71,0 %), gefolgt von der Genital‐ (25,8 %) und der Nasenschleimhaut (22,6 %). Im Vergleich zu anderen Patienten mit BP hatten Patienten mit Schleimhautbeteiligung eine ausgeprägtere palmoplantare Beteiligung (67,7 % vs. 37,2 %; p = 0,001); eine niedrigere Seropositivitätsrate (18,2 % vs. 54.2 %; p = 0,027) und niedrigere Konzentrationen (29,3 ± 64,5 vs. 129,5 ± 304,4 U/ml; p = 0,016) von Anti‐BP230‐Autoantikörpern; und verminderte periphere Eosinophilenzahlen (760,0 ± 638,6 vs. 1296,3 ± 1013,7; p < 0,001). Das Fehlen von Anti‐BP230‐Autoantikörpern (OR, 5,32; 95 %‐Konfidenzintervall [KI], 1,07–26,32; p = 0,026) und das Fehlen von einer peripheren Eosinophilie (OR, 4,31; 95 %‐KI, 1,14–16,39; p = 0,021) waren mit dem Vorhandensein einer Schleimhautbeteiligung bei BP assoziiert.SchlussfolgerungenEine Beteiligung der Schleimhäute findet sich in einer nennenswerten Subgruppe von Patienten mit BP und ist assoziiert mit dem Fehlen sowohl von Anti‐BP230‐Antikörpern als auch von peripherer Eosinophilie.
Expanding the clinical spectrum of anti‐IgLON5 disease: A multicenter retrospective study
Authors: Ni You , Shen Dingding , Zhang Ying , Song Yaying , Gao Yining , Zhou Qinming , He Lu , Yin Dou , Wang Ying , Song Fan , Chen Meiyuan , Lian Yajun , Chen Yuan , Zhao Xing , Zhang Xiang , Chen Xiangjun , Wang Yuting , Zhang Ling , Mo Nanxun , Lv Dong , Liu Jun , Mao Zhifeng , Peng Lisheng , Chen Sheng 
Published: September 2021

AbstractBackgroundWe conducted this study to describe detailed the clinical characteristics, ancillary test results and treatment response of a group of Chinese patients with anti‐IgLON5 disease.MethodsWe recruited 13 patients with positive IgLON5 antibodies in serum and/or cerebrospinal fluid from nine tertiary referral centers. Patients were enrolled from February 2017 to July 2021. We retrospectively collected information on the presenting and main symptoms, treatment response and follow‐up outcomes.ResultsThe median age of onset for symptoms was 60 (range: 33–73) years and six of the 13 patients were females. The predominant clinical presentations included sleep disturbance (eight patients) and cognitive impairment (seven patients), followed by movement disorders (six patients). Parainfectious cause seemed plausible. Notably, we identified the first case of possible Epstein‐Barr virus (EBV)‐related anti‐IgLON5 disease. Coexisting neural autoantibodies were identified in two patients. Furthermore, two patients had other autoimmune diseases. The IgG subclass was determined in four patients, including two with dominant IgG4 subtype and two with dominant IgG1 subtype. Additionally, 10 patients were treated with immunotherapy and four patients exhibited improvement. Overall, six of 10 patients for whom follow‐up results were assessable had favorable clinical outcomes (modified Rankin Scale score ≤2).ConclusionsThe clinical spectrum of anti‐IgLON5 disease is variable. Our results highlight a boarder spectrum of anti‐IgLON5 disease.
Provincial income convergence clubs in Indonesia: Identification and conditioning factors
Authors: Gunawan Anang Budi , Mendez Carlos , Otsubo Shigeru 
Published: September 2021

AbstractThe discussion on regional income per capita convergence in Indonesia continues with an emphasis on whether regional per capita incomes tend to converge or diverge over the long run. This study evaluates the regional convergence hypothesis at the provincial level during the recent deindustrialization period 2001–2017 of Indonesia. First, the study examines the existence of convergence clubs in Indonesia using a recently assembled panel dataset. Results reveal four convergence clubs with particularly large income gaps, mostly arising from the top of the income distribution. Second, using an ordered logit model, the study examines the determinants of the convergence clubs. Result reveals that industrialization increases the probability of membership to a high‐income club.
Google is goodish: An information literacy course designed to teach users why Google may not always be the best place to search for evidence
Authors: Lacey Patricia 
Published: September 2021

AbstractThis article describes a course that was developed in response to health sector and local authority workers being reliant on Google and using it for their information needs regardless of whether it was the best place to search. The methodology for developing and structuring the course is explored, including details of the content included. The author concludes by asserting that teaching users about the effective use of Google is an important part of user education. D.I.
An integrative review of oral manifestations in patients with COVID‐19: signs directly related to SARS‐CoV‐2 infection or secondary findings?
Authors: Reis Vanessa Paiva , Bezerra Adriana Raymundo , Maia Adriane Batista Pires , Marques Letícia Côgo , Conde Danielle Castex 
Published: September 2021

AbstractWe conducted an integrative review on oral manifestations in patients with COVID‐19 based on the current available literature evidence. A bibliographic search was carried out on March 11, 2021, among published studies in the years 2019–2021 in the PubMed database and based on the search strategy (“COVID‐19” AND “oral lesions” OR “oral mucositis” OR “oral manifestation”). After applying the inclusion and exclusion criteria, 29 articles were considered suitable for this review. A total of 110 cases of patients with COVID‐19 who had oral manifestations were reported. The presence of ulcerated lesions was the most common finding, having a herpetiform and aphthous clinical pattern observed in most cases. Macules, petechiae, hemorrhagic blisters, pustular enanthem, mucositis, and halitosis were also among the most frequently described oral manifestations. The tongue was the most commonly affected site, followed by the palate and lip. Most of the reported cases were diagnosed only by the clinical aspect of the lesion associated with a positive SARS‐CoV‐2 test or the presence of other COVID‐19 symptoms. Current scientific evidence still could not affirm that most of the oral lesions observed in patients with COVID‐19 are related to the virus's direct or indirect action on the oral mucosa. To confirm this association, prospective and longitudinal studies are further needed, together with a larger number of patients, complemented by histopathological examination of these lesions. Additionally, molecular techniques, such as immunohistochemistry and in situ hybridization, may be necessary to perform the differential diagnosis with other oral lesions.
Potential for novel imaging techniques to monitor early disease progression in connective tissue disease vasculopathy
Authors: Tan Kah Aik , Inderjeeth Charles , Jansen Shirley 
Published: September 2021

AbstractVasculopathy associated with connective tissue diseases (CTD) has diverse clinical presentations and complex underlying pathology. Existing imaging techniques remain inadequate for assessing vasculopathy in CTD, particularly in earlier stages of pathogenesis. Novel imaging techniques, such as optical coherence tomography, near‐infrared spectroscopy and superb microvascular imaging, demonstrate potential in monitoring disease progression at earlier stages prior to systemic complications.
Outcomes of artery embolisation for cystic fibrosis patients with haemoptysis: a 20‐year experience at a major Australian tertiary centre
Authors: Semasinghe Bandaralage Sahan P. , Tay George , Hay Karen , Megram Emma , Smith Daniel , Gadowski Tahlia , Wright Eimear , France Megan , Bell Scott , Reid David 
Published: September 2021

AbstractThere are no published data on Australian adult cystic fibrosis (CF) patient outcomes post bronchial arterial embolisation (BAE). We report 20 years of experience of BAE at a major Australian tertiary adult CF centre, where 46 patients underwent 100 BAE during this period. Mortality rate was comparable to previous studies (4% per year) and most who died had repeat BAE requirements. A higher proportion (9 out of 45) of patients were transplanted compared to previous publications. Repeat BAE was common and significantly higher in patients already on tranexamic acid.
Secret messengers: Extracellular RNA communication in the immune system
Authors: Nation Grant K , Saffold Cherie E , Pua Heather H 
Published: September 2021

AbstractOne of the hallmarks of the immune system is a dynamic landscape of cellular communication through the secretion of soluble factors, production of cell‐bound ligands, and expression of surface receptors. This communication affects all aspects of immune cell behavior, integrates the responses of immune cells in tissues, and is fundamental to orchestrating effective immunity. Recent pioneering work has shown that the transfer of ribonucleic acids (RNAs) constitutes a novel mode of cellular communication. This communication involves diverse RNA species, with short noncoding RNAs especially enriched in the extracellular space. These RNAs are highly stable and selectively packaged for secretion. Transferred RNAs have functions in target cells that both mirror their cell‐intrinsic roles and adopt novel mechanisms of action. These extracellular RNAs both impact the behavior of individual immune cells and participate in local and systemic immune responses. The impacts of RNA communication on immune cells and disease states have important implications for the development of novel clinical biomarkers and innovative therapeutic designs in immune‐related disease. In this review, we will discuss the foundation of knowledge that is establishing RNA communication as an active and functional process in the immune system.
LINC00261 elevation inhibits angiogenesis and cell cycle progression of pancreatic cancer cells by upregulating SCP2 via targeting FOXP3
Authors: Zou Jun , Pei Xuanzeng , Xing Dan , Wu Xiaojun , Chen Shuai 
Published: September 2021

AbstractLong non‐coding RNAs (lncRNAs) biological functions and molecular mechanisms associated with pancreatic cancer (PC) remain to be poorly elucidated. We aimed to clarify the role of lncRNA LINC00261 (LINC00261) in PC and confirm its regulatory mechanisms. Bioinformatics analysis, RNA pull‐down and RIP assays were performed to investigate relationship between LINC00261 and forkhead box P3 (FOXP3). Further, dual‐luciferase reporter gene and ChIP assays were employed to confirm the relationship among LINC00261, FOXP3 and sterol carrier protein‐2 (SCP2). PC cells were introduced with a series of vectors to verify the effects of LINC00261 and SCP2 on the viability, cell cycle progression, migration and angiogenesis of PC cells. Nude mice with the xenograft tumour were used to evaluate the effects LINC00261 on the tumourigenicity. LINC00261 was lowly expressed in PC tissues and cells. SCP2 was inhibited by LINC00261 through FOXP3. Functionally, upregulated LINC00261 or downregulated SCP2 led to reduced cell viability, migration, angiogenesis and tumourigenicity potentials. This study demonstrated the inhibitory role of LINC00261 in the angiogenesis and cell cycle progression of PC cells. It acts through the negative regulation of SCP2 via targeting FOXP3. Findings in this study highlight a potentially biomarker for PC treatment.
Sleepy drivers on a slippery road: A pilot study using a driving simulator
Authors: Radun Igor , Levitski Andres , Wahde Mattias , Ingre Michael , Benderius Ola , Radun Jenni , Kecklund Göran 
Published: September 2021

SummarySleepy drivers have problems with keeping the vehicle within the lines, and might often need to apply a sudden or hard corrective steering wheel movement. Such movements, if they occur while driving on a slippery road, might increase the risk of ending off road due to the unforgiving nature of slippery roads. We tested this hypothesis. Twelve young men participated in a driving simulator experiment with two counterbalanced conditions; dry versus slippery road × day (alert) versus night (sleepy) driving. The participants drove 52.5 km on a monotonous two‐lane highway and rated their sleepiness seven times using the Karolinska Sleepiness Scale. Blink durations were extracted from an electrooculogram. The standard deviation of lateral position and the smoothness of steering events were measures of driving performance. Each outcome variable was analysed with mixed‐effect models with road condition, time‐of‐day and time‐on‐task as predictors. The Karolinska Sleepiness Scale increased with time‐on‐task (p < 0.001) and was higher during night drives (p < 0.001), with a three‐way interaction suggesting a small increased sleepiness with driving time at night with slippery road conditions (p = 0.012). Blink durations increased with time‐on‐task (p < 0.01) with an interaction between time‐of‐day and road condition (p = 0.040) such that physiological sleepiness was lower for sleep‐deprived participants in demanding road conditions. The standard deviation of lateral position increased with time‐on‐task (p = 0.026); however, during night driving it was lower on a slippery road (p = 0.025). The results indicate that driving in demanding road condition (i.e. slippery road) might further exhaust already sleepy drivers, although this is not clearly reflected in driving performance.
Population dynamics of Hypselobarbus thomassi (Day 1874), an endemic cyprinid fish from a tropical reservoir of Southern Western Ghats, India
Authors: Renjithkumar Chelapurath Radhakrishnan , Roshni Kuttanelloor , Harikrishnan Mahadevan , Madhusoodana Kurup Balakrishna 
Published: September 2021

AbstractThe Western Ghats of peninsular India is a highly sensitive and threatened ecoregion of exceptional freshwater ichthyodiversity. The present study investigated the growth, mortality and stock characteristics of Hypselobarbus thomassi, an endemic cyprinid fish from the Parappar Reservoir of Western Ghats, on the basis of the length‐frequency data collected during the period from 2009 to 2011. The growth parameters of this species were estimated using the FiSAT program, and the asymptotic length (L∞) and growth constant (K) being 476.79 mm and 0.39 year−1, respectively. The age at zero length (t0) was calculated as −0.0485 year−1. The longevity (tmax) and growth performance index (ϕ) were reported as 7.69 years and 2.95. The estimated total mortality (Z), natural mortality (M) and fishing mortality (F) were 1.65, 0.38 and 1.27 year−1, respectively. The relative yield per recruit (Y/R) analysis revealed the exploitation rate (E) at different levels as E0.1 = 0.36, E0.5 = 0.28 and Emax = 0.42. The current exploration level (0.77) is higher than the optimum exploitation rate (Emax = 0.42), indicating an overexploitation of the H. thomassi population. Accordingly, needed management measures should include restrictions on fishing gear mesh sizes, reduced fishing effort and declaration of closed seasons and sanctuaries to protect this threatened species.
Life‐history traits of three Ambassid fishes (Chanda nama, Parambassis lala and Parambassis ranga) from the Mathabhanga River, southwestern Bangladesh
Authors: Hossain Md. Yeamin , Hossen Md. Alomgir , Mawa Zannatul , Rahman Md. Ataur , Hasan Md. Rabiul , Islam Md. Akhtarul , Khatun Dalia , Rahman Md. Ashekur , Tanjin Sumaya , Sarmin Most. Shakila , Bashar Md. Abul , Ohtomi Jun 
Published: September 2021

ABSTRACTThe present study provides the first indication of the life‐history traits, including, population structure, growth pattern, condition factor, form factor (a3.0), size at first sexual maturity (Lm), natural mortality (MW) and optimum catchable length (Lopt), of three Ambassid (Chanda nama, Parambassis lala and Parambassis ranga) fishes from the Mathabhanga River in southwest Bangladesh. A total of 370 individuals were occasionally collected from August 2017 to July 2018 with cast nets, gill nets, square lift nets, and conical‐ and box‐traps. The total length (TL) ranged from 2.4 to 7.5 cm for C. nama, 1.9–3.8 cm for P. lala and 1.8–6.5 cm for P. ranga. The length‐frequency distributions (LFDs) showed the 4.0–5.0 cm TL size group for C. nama and the 3.0–4.0 cm TL size group were numerically dominant for P. lala and P. ranga. The length–weight relationships (LWRs) indicated isometric growth for C. nama, and positive allometric growth for P. lala and P. ranga. All the LWR values were very significant (p < .001), with all r2 values > .950. Based on the Spearman rank correlation test, body weight (BW) versus Fulton's‐condition factor (KF) was extremely correlated (p < .001), indicating a better wellbeing for these species. The a3.0 value was 0.0082, 0.0138 and 0.0104 for C. nama, P. lala and P. ranga, respectively. Based on the maximum length (Lmax), the Lm was 4.4 cm TL for C. nama, 2.5 cm TL for P. lala, and 4.0 cm TL for P. ranga. Based on the asymptotic length (L∞), the Lm was 4.88 cm TL for C. nama, 2.63 cm TL for P. lala, and 4.28 cm TL for P. ranga. The MW value was 2.2, 3.3 and 2.7/year for C. nama, P. lala and P. ranga, respectively. The optimum catchable length (Lopt) was 5.36 cm TL for C. nama, 2.75 cm TL for P. lala and 4.65 cm TL for P. ranga. The findings of the present study should be very useful for effective and sustainable management of these fishes in the Mathabhanga River and the connecting ecosystems.
Evaluating the fishery of tropical reservoirs using surplus production models: A case study of Aliyar Reservoir, Tamil Nadu, India
Authors: Geethalakshmi Vaidhyanathan , Chandrasekar V. , Shanmugavel Chinnadurai , Hassan Femeena , Gopal Nikita 
Published: September 2021

AbstractReservoir fisheries support the livelihood needs of socio‐economically deprived fishers and ensure the nutritional security of rural populations. To sustain community food safety and economic needs, a basic understanding of the prevailing biological and economic conditions, as well as a comprehensive evaluation of the fishery is essential. To this end, the present study focused on evaluating the fisheries of the small Aliyar Reservoir located in the Coimbatore District of the state of Tamil Nadu, India, utilizing surplus production models. The maximum recorded fish catch was 51.3 MT in 2015, with the minimum catch of 10.89 MT obtained in 1991, and the average production during 1985 to 2018 being 30.80 MT from the reservoir. The peak catch season was during the months of February to May. The MSY (Maximum Sustainable Yield) and other key fish population parameters, including the carrying capacity (K), catchability coefficient (q), intrinsic population growth rate (r) and coefficient of variation (CV), using catch and effort data (CEDA) analysis and ASPIC (a surplus production model incorporating covariates) computer software packages. Using CEDA software, the estimated MSY was 36.92 MT (CV = 0.47) using the Fox model and 36.68 MT (CV = 0.307) using the Schaefer model. An integrated surplus production model (CYP) of Clarke et al. (Marine Research Economics, 1992, 7, 115) was also fitted to the data and found to be the best fit with the MSY, an estimated optimum effort of 51.20 MT and 5110 nets/year. The results indicated the need for increasing the fishing effort with appropriate standard gears for exploiting the fish stock. Further economic optimization with the CYP model indicates increasing the fishing effort by 34% will lead to a 40% increase in the annual profits for the fishermen.
Sodium‐glucose co‐transporter 2 inhibitors on weight change and cardiometabolic profiles in individuals with overweight or obesity and without diabetes: A meta‐analysis
Authors: Wong John , Chan Kwan Yi , Lo Kenneth 
Published: September 2021

SummarySeveral meta‐analyses have been conducted to evaluate the weight loss effect of sodium–glucose cotransporter 2 (SGLT‐2) inhibitors in patients with type 2 diabetes, whereas pooled analysis focusing on individuals without diabetes is lacking. The objective of this systematic review and meta‐analysis is to evaluate the effect of SGLT‐2 inhibitor monotherapy on weight change and cardiometabolic profiles. Multiple databases were searched for randomized controlled trials reporting weight change effect of SGLT‐2 inhibitor treatment compared with placebo for more than 12 weeks among individuals with overweight or obesity and without diabetes. A total of eight randomized controlled trials with 750 subjects were identified. SGLT‐2 monotherapy was associated with significant reduction in body weight of −2.32 kg, compared to −1.01 kg for placebo, giving a mean difference of −1.31 kg. Significant reductions in body mass index and fasting blood glucose were observed, but not for the changes in waist circumference, fat mass, blood pressure, and lipid profile compared with placebo. SGLT‐2 inhibitor monotherapy for 12 weeks or more can result in modest weight loss among people with overweight or obesity and without diabetes. Depending on pre‐existing comorbidities or risk factors, SGLT‐2 inhibitors can be considered adjuncts in the treatment of obesity.