bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced thermal stability and adsorption performance of MIL-53(Fe)@montmorillonite
Authors: Dai Fengli , Guo Junhui , He Yufeng , Song Pengfei , Wang Rongmin 
Published: July 2021

AbstractMontmorillonite (Mnt), a clay mineral with a nanolayered structure, was combined with an Fe-based metal–organic framework (MOF; MIL-53(Fe)) using an in situ growth technique that yielded a novel eco-friendly clay-based adsorbent (MIL-53(Fe)@Mnt). The adsorbent was characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis and N2 gas adsorption. The MIL-53(Fe) particles grew on the surface of the nanolayered Mnt and the MIL-53(Fe) particle size became smaller. The adsorption performance of MIL-53(Fe)@Mnt was investigated by removing methylene blue (MB), and optimization experiments were carried out to study the effects of contact time, pH, initial dye concentration and adsorbent mass on the adsorption processes. The MIL-53(Fe)@Mnt exhibited excellent adsorption capacity for MB, namely 313.7 mg g−1, which was 3.02 times and 3.54 times greater than that of pure Mnt and MIL-53(Fe), respectively. Adsorption was fitted with the Langmuir isotherm model and followed a pseudo-second order kinetic model. The MIL-53(Fe)@Mnt obtained is a low-cost and eco-friendly adsorbing material and might be a candidate for removing dyes during water treatment.
Zvěstovite-(Zn), Ag6(Ag4Zn2)As4S13, a new tetrahedrite-group mineral from Zvěstov, Czech Republic
Authors: Sejkora Jiří , Biagioni Cristian , Vrtiška Luboš , Moëlo Yves 
Published: July 2021

AbstractThe new mineral, zvěstovite-(Zn), ideally Ag6(Ag4Zn2)As4S13, was found in quartz–baryte gangue at the mine dump of the abandoned small deposit of Zvěstov, central Bohemia, Czech Republic. Zvěstovite-(Zn) is associated with tennantite-(Zn), tetrahedrite-(Zn), argentotennantite-(Zn), acanthite and supergene azurite and malachite. The new mineral occurs as rare relic anhedral grains rimmed by acanthite, up to 100 μm in size. Zvěstovite-(Zn) is grey, Mohs hardness is ca. 3½–4, in agreement with other members of the tetrahedrite group; the calculated density is 5.16 g.cm–3. In reflected light, zvěstovite-(Zn) is grey with a greenish tint, without bireflectance, pleochroism or anisotropy. Deep red internal reflections are ubiquitous. Reflectance values of zvěstovite-(Zn) in air (R%) are: 28.5 at 470 nm, 26.9 at 546 nm, 25.5 at 589 nm and 23.8 at 650 nm. The empirical formula for zvěstovite-(Zn), based on electron-microprobe analyses (n = 4), is Ag6.27[(Ag3.90Cu0.38)Σ4.28(Zn1.60Fe0.09Cd0.03)Σ1.72]Σ6.00(As2.26Sb1.48)Σ3.74S12.50. The ideal formula is Ag6(Ag4Zn2)As4S13, which requires (in wt.%) Ag 56.01, Zn 6.79, As 15.56 and S 21.64, total 100.00. Zvěstovite-(Zn) is cubic, I$\bar{4}$3m, with unit-cell parameters: a = 10.850(2) Å, V = 1277.3(8) Å3 and Z = 2. The strongest reflections of the calculated powder X-ray diffraction pattern [d, Å (I) (hkl)] are: 3.1321(100) (222), 2.7125(21) (400), 1.9809(11) (521), 1.9180(31) (440) and 1.6357(15) (622). According to the single-crystal X-ray diffraction data (Robs = 0.051), the crystal structure of zvěstovite-(Zn) agrees with the general features of the members of the tetrahedrite group. Zvěstovite-(Zn) is named after its type locality, Zvěstov; the suffix indicates the dominant divalent C-constituent, according to the approved nomenclature of the tetrahedrite group. It is the As-isotype of rozhdestvenskayaite-(Zn). The mineral and its name have been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association (IMA2020-061).
Factors affectıng recurrence after trımodal treatment ın ınvasıve bladder cancer
Authors: Solakhan Mehmet , Benlier Necla , Yıldırım Zeliha , Seran Ali Ihsan , Kaya Vildan , Yıldırım Mustafa 
Published: July 2021

Abstract
Background
In this study, we aimed to determine which patients will benefit most from TMT treatment, and to evaluate the factors affecting relapse, survival and response to treatment separately.

Methods
For the study, patients who presented to our hospital’s outpatient clinic between 2010 and 2020 and were diagnosed with locally advanced (T2-G3) invasive urothelial bladder cancer and treated with gemcitabine concomitantly with radiotherapy following complete TUR were identified. A total of 112 patients with transitional cell bladder cancer invading the muscle were enrolled in the study including 88 (78.6%) males and 24 (21.4%) females.

Results
Tumor location was significantly associated with tumor recurrence (p = 0.003). Recurrence at follow-up was significantly associated with the number of tumor foci (p = 0.008). Median duration of follow-up and median progression-free survival were 41.50 months and 65 ± 4.21 (95% CI, 56.74-73.25) months, respectively. Progression-free survival was not statistically significantly associated with neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR) or BMI (p = 0.32, p = 0.47, p = 0.39, respectively), but muscle invasion during follow-up was significantly associated with progression-free survival (p = 0.009).

Conclusions
Tumor location, the number of tumor foci, history of multiple transurethral resection surgeries and a NLR ≥ 2.56 were significantly associated with recurrence following Trimodal therapy (TMT). A lower rate of recurrence was observed among patients undergoing early TMT after initial diagnosis. None of the patients treated with trimodal therapy experienced severe adverse effects. Therefore, trimodal therapy is a safe, effective and tolerable therapeutic option with a low rate of recurrence in selected eligible patients.
Reactivation of Vogt-Koyanagi-Harada disease under control for more than 6 years, following anti-SARS-CoV-2 vaccination
Authors: Papasavvas Ioannis , Herbort Carl P. 
Published: July 2021

Abstract
Background/purpose
Vogt-Koyanagi-Harada (VKH) disease is a primary stromal choroiditis with bilateral granulomatous panuveitis. If initial-onset VKH is treated early and relentlessly the disease can be controlled and even “cured” in a substantial number of cases. We are reporting on a patient treated early and in a sustained fashion who was inflammation free for seven years but who presented a reactivation 6 weeks after the second dose of anti-SARS-CoV-2 vaccination.

Case report
A 43-year-old woman presented with severe initial-onset VKH disease which was brought under control using steroidal and non-steroidal Immunosuppression (mycophenolic acid and cyclosporine) with additional infliximab infusions because of the persistence of subclinical choroiditis identified on ICGA. Under infliximab alone disease had been inflammation free with no subclinical disease and absence of sunset glow fundus for 6 years. However, following anti-SARS-CoV-2 vaccination, severe resurgence of the disease occurred with exudative retinal detachments. Disease was rapidly brought again under control with oral prednisone (1 mg/kg) therapy and a new loading scheme of infliximab therapy.

Conclusion
VKH disease results from an autoimmune process directed against melanocyte associated antigens which can be controlled when early and sustained immunosuppressive treatment is introduced. It seems that anti-SARS-CoV-2 vaccination can be at the origin of reactivation of long-time controlled disease.
Dentition and feeding in Placodontia: tooth replacement in Henodus chelyops
Authors: Pommery Yannick , Scheyer Torsten M. , Neenan James M. , Reich Tobias , Fernandez Vincent , Voeten Dennis F. A. E. , Losko Adrian S. , Werneburg Ingmar 
Published: July 2021

Abstract
Background
Placodontia is a Triassic sauropterygian reptile group characterized by flat and enlarged crushing teeth adapted to a durophagous diet. The enigmatic placodont Henodus chelyops has numerous autapomorphic character states, including extreme tooth count reduction to only a single pair of palatine and dentary crushing teeth. This renders the species unusual among placodonts and challenges identification of its phylogenetic position.

Results
The skulls of two Henodus chelyops specimens were visualized with synchrotron tomography to investigate the complete anatomy of their functional and replacement crushing dentition in 3D. All teeth of both specimens were segmented, measured, and statistically compared to reveal that H. chelyops teeth are much smaller than the posterior palatine teeth of other cyamodontoid placodonts with the exception of Parahenodus atancensis from the Iberian Peninsula. The replacement teeth of this species are quite similar in size and morphology to the functional teeth.

Conclusion
As other placodonts, Henodus chelyops exhibits vertical tooth replacement. This suggests that vertical tooth replacement arose relatively early in placodont phylogeny. Analysis of dental morphology in H. chelyops revealed a concave shape of the occlusal surface and the notable absence of a central cusp. This dental morphology could have reduced dental wear and protected against failure. Hence, the concave teeth of H. chelyops appear to be adapted to process small invertebrate items, such as branchiopod crustaceans. Small gastropods were encountered in the matrix close to both studied skulls.
GA3 is superior to GA4 in promoting bud endodormancy release in tree peony (Paeonia suffruticosa) and their potential working mechanism
Authors: Yuxi Zhang , Yanchao Yuan , Zejun Liu , Tao Zhang , Feng Li , Chunying Liu , Shupeng Gai 
Published: July 2021

Abstract
Background
Sufficient low temperature accumulation is the key strategy to break bud dormancy and promote subsequent flowering in tree peony anti-season culturing production. Exogenous gibberellins (GAs) could partially replace chilling to accelerate dormancy release, and different kinds of GAs showed inconsistent effects in various plants. To understand the effects of exogenous GA3 and GA4 on dormancy release and subsequent growth, the morphological changes were observed after exogenous GAs applications, the differentially expressed genes (DEGs) were identified, and the contents of endogenous phytohormones, starch and sugar were measured, respectively.

Results
Morphological observation and photosynthesis measurements indicated that both GA3 and GA4 applications accelerated bud dormancy release, but GA3 feeding induced faster bud burst, higher shoot and more flowers per plant. Full-length transcriptome of dormant bud was used as the reference genome. Totally 124 110 459, 124 015 148 and 126 239 836 reads by illumina transcriptome sequencing were obtained in mock, GA3 and GA4 groups, respectively. Compared with the mock, there were 879 DEGs and 2 595 DEGs in GA3 and GA4 group, 1 179 DEGs in GA3 vs GA4, and 849 DEGs were common in these comparison groups. The significant enrichment KEGG pathways of 849 DEGs highlighted plant hormone signal transduction, starch and sucrose metabolism, cell cycle, DNA replication, etc. Interestingly, the contents of endogenous GA1, GA3, GA4, GA7 and IAA significantly increased, ABA decreased after GA3 and GA4 treatments by LC–MS/MS. Additionally, the soluble glucose, fructose and trehalose increased after exogenous GAs applications. Compared to GA4 treatment, GA3 induced higher GA1, GA3 and IAA level, more starch degradation to generate more monosaccharide for use, and promoted cell cycle and photosynthesis. Higher expression levels of dormancy-related genes, TFL, FT, EBB1, EBB3 and CYCD, and lower of SVP by GA3 treatment implied more efficiency of GA3.

Conclusions
Exogenous GA3 and GA4 significantly accelerated bud dormancy release and subsequent growth by increasing the contents of endogenous bioactive GAs, IAA, and soluble glucose such as fructose and trehalose, and accelerated cell cycle process, accompanied by decreasing ABA contents. GA3 was superior to GA4 in tree peony forcing culture, which might because tree peony was more sensitive to GA3 than GA4, and GA3 had a more effective ability to induce cell division and starch hydrolysis. These results provided the value data for understanding the mechanism of dormancy release in tree peony.
Management of enterococcal central line-associated bloodstream infections in patients with cancer
Authors: Awadh Hesham , Chaftari Anne-Marie , Khalil Melissa , Fares Johny , Jiang Ying , Deeba Rita , Ali Shahnoor , Hachem Ray , Raad Issam I. 
Published: July 2021

Abstract
Objective
Enterococcus species are the third most common organisms causing central line-associated bloodstream infections (CLABSIs). The management of enterococcal CLABSI, including the need for and timing of catheter removal, is not well defined. We therefore conducted this study to determine the optimal management of enterococcal CLABSI in cancer patients.

Methods
We reviewed data for 542 patients diagnosed with Enterococcus bacteremia between September 2011 to December 2018. After excluding patients without an indwelling central venous catheter (CVC), polymicrobial bacteremia or with CVC placement less than 48 h from bacteremia onset we classified the remaining 397 patients into 3 groups: Group 1 (G1) consisted of patients with CLABSI with mucosal barrier injury (MBI), Group 2 (G2) included patients with either catheter-related bloodstream infection (CRBSI) as defined in 2009 Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection by the Infectious Diseases Society of America (IDSA) or CLABSI without MBI, and Group 3 (G3) consisted of patients who did not meet the CDC criteria for CLABSI. The impact of early (< 3 days after bacteremia onset) and late (3–7 days) CVC removal was compared. The composite primary outcome included absence of microbiologic recurrence, 90-day infection-related mortality, and 90-day infection-related complications.

Results
Among patients in G2, CVC removal within 3 days of bacteremia onset was associated with a trend towards a better overall outcome than those whose CVCs were removed later between days 3 to 7 (success rate 88% vs 63%). However, those who had CVCs retained beyond 7 days had a similar successful outcome than those who had CVC removal < 3 days (92% vs. 88%). In G1, catheter retention (removal > 7 days) was associated with a better success rates than catheter removal between 3 and 7 days (93% vs. 67%, p = 0.003). In non-CLABSI cases (G3), CVC retention (withdrawal > 7 days) was significantly associated with a higher success rates compared to early CVC removal (< 3 days) (90% vs. 64%, p = 0.006).

Conclusion
Catheter management in patients with enterococcal bacteremia is challenging. When CVC removal is clinically indicated in patients with enterococcal CLABSI, earlier removal in less than 3 days may be associated with better outcomes.
Based on our data, we cannot make firm conclusions about whether earlier removal (< 3 days) could be associated with better outcomes in patients with Enterococcal CLABSI whose CVC withdrawal is clinically indicated. In contrast, it seemed that catheter retention was associated to higher success outcome rates. Therefore, future studies are needed to clearly assess this aspect.
Steroid responsive cavernous sinus syndrome due to Rosai-Dorfman disease: beyond Tolosa-Hunt syndrome – a case report
Authors: Nóbrega Paulo Ribeiro , Rodrigues Pedro Gustavo Barros , de Sousa Pereira Isabelle , de Figueiredo Santos Carolina , Gerson Gunter , de Arruda José Arnaldo Motta , Júnior José Wagner Leonel Tavares , de Araújo Coimbra Pablo Picasso , Braga-Neto Pedro 
Published: July 2021

Abstract
Background
The term “Tolosa-Hunt syndrome” (THS) has been used to refer to painful ophthalmoplegia associated with nonspecific inflammation of the cavernous sinus and many processes can result in a similar clinical picture, including infectious, inflammatory and neoplastic diseases. Rosai-Dorfman disease (RDD) is a lymphoproliferative disorder that rarely affects the central nervous system. We report a case of isolated CNS Rosai-Dorfman disease involving the cavernous sinus and presenting as “Tolosa-Hunt syndrome”.

Case presentation
Our patient presented with horizontal diplopia due to impairment of cranial nerves III, IV and VI and a stabbing/throbbing headache predominantly in the left temporal and periorbitary regions. There was a nonspecific enlargement of the left cavernous sinus on MRI and the patient had a dramatic response to steroids. Biopsy of a frontal meningeal lesion was compatible with RDD.

Conclusions
We highlight the importance of including Rosai-Dorfman disease as a differential diagnosis in cavernous sinus syndrome and demonstrate a satisfactory long-term response to steroid treatment in this disease.
Sex and age differences in isolated traumatic brain injury: a retrospective observational study
Authors: Hosomi Sanae , Kitamura Tetsuhisa , Sobue Tomotaka , Ogura Hiroshi , Shimazu Takeshi 
Published: July 2021

Abstract
Background
Among the many factors that may influence traumatic brain injury (TBI) progression, sex is one of the most controversial. The objective of this study was to investigate sex differences in TBI-associated morbidity and mortality using data from the largest trauma registry in Japan.

Methods
This retrospective, population-based observational study included patients with isolated TBI, who were registered in a nationwide database between 2004 and 2018. We excluded patients with extracranial injury (Abbreviated Injury Scale score ≥ 3) and removed potential confounding factors, such as non-neurological causes of mortality. Patients were stratified by age and mortality and post-injury complications were compared between males and females.

Results
A total of 51,726 patients with isolated TBI were included (16,901 females and 34,825 males). Mortality across all ages was documented in 12.01% (2030/16901) and 12.76% (4445/34825) of males and females, respectively. The adjusted odds ratio (OR) of TBI mortality for males compared to females was 1.32 (95% confidence interval [CI], 1.22–1.42]. Males aged 10–19 years and ≥ 60 years had a significantly higher mortality than females in the same age groups (10–19 years: adjusted OR, 1.97 [95% CI, 1.08–3.61]; 60–69 years: adjusted OR, 1.24 [95% CI, 1.02–1.50]; 70–79 years: adjusted OR, 1.20 [95% CI, 1.03–1.40]; 80–89 years: adjusted OR, 1.50 [95% CI, 1.31–1.73], and 90–99 years: adjusted OR, 1.72 [95% CI, 1.28–2.32]). In terms of the incidence of post-TBI neurologic and non-neurologic complications, the crude ORs were 1.29 (95% CI, 1.19–1.39) and 1.14 (95% CI, 1.07–1.22), respectively, for males versus females. This difference was especially evident among elderly patients (neurologic complications: OR, 1.27 [95% CI, 1.14–1.41]; non-neurologic complications: OR, 1.29 [95% CI, 1.19–1.39]).

Conclusions
In a nationwide sample of patients with TBI in Japan, males had a higher mortality than females. This disparity was particularly evident among younger and older generations. Furthermore, elderly males experienced more TBI complications than females of the same age.
A computational multi-targeting approach for drug repositioning for psoriasis treatment
Authors: Ibezim Akachukwu , Onah Emmanuel , Dim Ebubechukwu N. , Ntie-Kang Fidele 
Published: July 2021

Abstract
Background
Psoriasis is an autoimmune inflammatory skin disease that affects 0.5–3% of the world’s population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for repositioned drug candidates and the time and cost-effectiveness has popularized drug reposition and computational methods in the drug research community.

Results
The current study attempts to reposition approved drugs for the treatment of psoriasis by docking about 2000 approved drug molecules against fifteen selected and validated anti-psoriatic targets. The docking results showed that a good number of the dataset interacted favorably with the targets as most of them had − 11.00 to − 10.00 kcal/mol binding free energies across the targets. The percentage of the dataset with binding affinity higher than the co-crystallized ligands ranged from 34.76% (JAK-3) to 0.73% (Rac-1). It was observed that 12 out of the 0.73% outperformed all the co-crystallized ligands across the 15 studied proteins. All the 12 drugs identified are currently indicated as either antiviral or anticancer drugs and are of purine and pyrimidine nuclei. This is not surprising given that there is similarity in the mechanism of the mentioned diseases.

Conclusion
This study, therefore, suggests that; antiviral and anticancer drugs could have anti-psoriatic effects, and molecules with purine and pyrimidine structural architecture are likely templates to consider in developing anti-psoriatic agents.
Ruyiping formula inhibits metastasis via the microRNA-134-SLUG axis in breast cancer
Authors: Jiang Ziwei , Pei Lixia , Xie Ying , Ye Qun , Liang Xiaoqiang , Ye Yiyi , Liu Sheng 
Published: July 2021

Abstract
Background
Metastasis is the leading cause of death among breast cancer patients. MicroRNA-134 has been reported to have a tumor-suppressive role in breast cancer. Ruyiping (RYP), a traditional Chinese formula, has been shown with the ability to reduce breast cancer metastasis in pre-clinical studies. This present study was designed to examine whether miR-134 was involved in RYP-inhibited breast cancer metastasis.

Methods
The expression of SLUG, E-Cadherin, N-Cadherin and miR-134 in MDA-MB-231 and 4 T1 cells treated with RYP or vehicle control were determined by quantitative realtime-PCR and western blot. Invasiveness determined by transwell assay as well as SLUG gene expression determined by qPCR were detected in cells transfected with chemically synthesized miR-134 mimics or inhibitors. BALB/c mice were injected with 4 T1 cells orthotopically and fed with RYP through gavage. Breast tumor growth, metastasis and tumor expression of EMT markers were detected.

Results
Compared with the control, Ruyiping formula significantly inhibited SLUG-regulated breast cancer cells invasion. MiR-134 was induced by RYP in vitro and in vivo and was able to suppress SLUG by targeting its 3’UTR. RYP suppressed SLUG expression and cell invasion through miR-134. In 4 T1 tumor-bearing mice, RYP significantly inhibited 4 T1 tumor growth and lung metastasis, increased the levels of miR-134 and epithelial marker while decreased the levels of SLUG and mesenchymal marker.

Conclusion
Our data uncovered that Ruyiping formula exerts an anti-metastatic activity against breast cancer cells by regulating SLUG through miR-134. MiR-134-SLUG axis might be a promising strategy in breast cancer therapy.