bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical observation on prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation
Authors: Huang Yan-Mei , Ouyang Dong 
Published: December 2024

BACKGROUND
A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different treatment options.
AIM
To analyze the clinical effect and prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation (RPH).
METHODS
A total of 100 patients with mixed hemorrhoids who visited our hospital from October 2022 to September 2023 were selected and randomly divided into the control group (n = 50) and the treatment group (n = 50) by rolling the dice. The procedure for prolapse and hemorrhoids (PPH) was adopted in the control group, while polidocanol foam injection + RPH was adopted in the treatment group. The therapeutic effects, operation time, wound healing time, hospital stay, pain situation (24 hours post-operative pain score, first defecation pain score), quality of life (QOL), incidence of complications (post-operative hemorrhage, edema, infection), incidence of anal stenosis 3 months post-operatively and recurrence rate 1 year post-operatively of the two groups were compared.
RESULTS
Compared with the control group, the total effective rate of treatment group was higher, and the difference was significant (P < 0.05). The operation time/wound healing time/hospital stay in the treatment group were shorter than those in the control group (P < 0.05). The pain scores at 24 hours after operation/first defecation pain score of the treatment group was significantly lower than those in the control group (P < 0.05). After surgery, the QOL scores of the two groups decreased, with the treatment group having higher scores than that of the control group (P < 0.05). Compared with the control group, the incidence of postoperative complications in the treatment group was lower, and the difference was significant (P < 0.05); However, there was no significant difference in the incidence of postoperative bleeding between the two groups (P > 0.05); There was no significant difference in the incidence of anal stenosis 3 months after operation and the recurrence rate 1 year after operation between the two groups (P > 0.05).
CONCLUSION
For patients with mixed hemorrhoids, the therapeutic effect achieved by using polidocanol injection combined with RPH was better. The wounds of the patients healed faster, the postoperative pain was milder, QOL improved, and the incidence of complications was lower, and the short-term and long-term prognosis was good.
Primary duodenal T/histiocyte-rich large B-cell lymphoma complicated with obstructive jaundice: A case report and review of literature
Authors: Chen Xing-Yu , Yang Jia-Yi , Chen Yi-Hua , Liu A-Niu , Wu Shan-Shan , Ji Zhi Se-Niu , Zheng Shu-Mei 
Published: December 2024

BACKGROUND
T/histiocyte-rich large B-cell lymphoma (T/HRBCL) is a highly aggressive subtype of diffuse large B-cell lymphoma characterized histologically by the presence of a few neoplastic large B cells amidst an abundant background of reactive T lymphocytes and/or histiocytes. T/HRBCL commonly affects the lymph nodes, followed by extranodal sites, such as the spleen, liver, and bone marrow, with rare occurrences in the gastrointestinal tract. Primary gastrointestinal T/HRBCL lacks specific clinical and endoscopic manifestations, and it is difficult to differentiate from inflammatory diseases, nodular lymphocyte predominant Hodgkin lymphoma, and other diseases on a histological basis, thereby hindering early diagnosis.
CASE SUMMARY
A 63-year-old man was hospitalized with a one-month history of jaundice and weight loss of approximately 3 kg. Laboratory tests revealed increased hepatic parameters in a cholestatic pattern and elevated carbohydrate antigen 19-9 levels. An abdominal computed tomography scan revealed a low-density mass within the descending duodenum and dilation of the bile and pancreatic ducts. He was clinically diagnosed with a duodenal tumor. During surgery, a 7.0 cm × 8.0 cm mass was identified within the descending duodenum, so pancreaticoduodenectomy and cholecystectomy were performed. Following operative biopsy, the tumor was diagnosed as primary duodenal T/HRBCL. The patient refused postoperative chemotherapy and died four months after surgery.
CONCLUSION
Primary duodenal T/HRBCL is an extremely rare and highly aggressive malignancy. The initial treatment strategies should be based on the original site of the tumor, the disease stage, and the patient's physical condition. Chemotherapy-based comprehensive treatment is still the main treatment method for primary gastrointestinal T/HRBCL.
Proposed computed tomography severity index for the evaluation of invasive fungal sinusitis: Preliminary results
Authors: Manchanda Smita , Bhalla Ashu S , Nair Ankita D , Sikka Kapil , Verma Hitesh , Thakar Alok , Kakkar Aanchal , Khan Maroof A 
Published: December 2024

BACKGROUND
Invasive fungal sinusitis (IFS) can present as a mild disease to life-threatening infection. A recent surge in cases was seen due to the coronavirus disease 2019 (COVID-19) pandemic. Many patients require surgical debridement and hence imaging [contrast-enhanced computed tomography (CECT) of the paranasal sinuses (PNS)] to document the extent of the disease. However, there was no scoring system using CECT to describe the severity of IFS. This study proposes a computed tomography (CT) severity index (CTSI) to describe the severity of rhino-orbital-cerebral involvement in symptomatic COVID-19 patients and hypothesizes that higher CTSI correlates with disease severity and thus slow response/non-response to treatment.
AIM
To propose a scoring system using CECT to describe the severity of IFS and correlate it with clinical outcomes.
METHODS
A prospective study on 66 COVID-19 positive patients with CECT PNS done for IFS was performed. Split-bolus single-phase CT technique was used. Based on the extent of involvement, a CTSI was designed. Disease in four major subsite areas was assessed. Each subsite involvement was given points according to this model and then summated. Based on the final summated CTSI, the disease was classified as mild, moderate, or severe. Two subsets were subsequently analyzed including survival and death; and responders and non-responders.
RESULTS
The study cohort was 66 COVID-19-positive patients with suspected IFS with a median age of 48.5 years. Mild disease was noted in 34 (51.52%), moderate in 28 (42.42%), and severe disease in 4 (6.06%) patients. There was a significant association of mortality and poor clinical response (P = 0.02) with disease bilaterality. Laterality and CTSI were significant predictors of response to treatment. The mean CTSI of responders was 6.3, of non-responders was 12.9 and the response to treatment was significantly associated with CTSI (t -test, P < 0.001). Receiver operating characteristic curve analysis (Liu method) to distinguish between responders and non-responders showed that the cut-off value for CTSI of 11 had a sensitivity of 78.26% and a specificity of 95.35% to predict response assessment.
CONCLUSION
CTSI can help in quantification of the disease burden, mapping out disease extent, triaging patients, and response assessment; especially patients with underlying comorbidities. A higher score would alert the clinician to initiate aggressive treatment, as severe disease correlates with slow response/non-response to the treatment.
The Process of Felinization in the Digital Age: the Utilisation of Cats as a Strategy for the Formation of a New Identity
Authors: Tikhonova Sophia V. , Rezvushkina Sofya A. 
Published: December 2024

The contemporary cultural practices associated with animals give rise to a novel dual concept of corporeality and sensuality. The growth of consumerism in accordance with the feline model of consumption gives rise to the formation of a society where the characteristics associated with the feline species become the prevailing norm. In light of the above, it seems pertinent to examine the strategies of social felinization and to identify the symbolic repressive markers that maintain it, as evidenced in viral cat content. The examination of the most prevalent feline-themed materials on the post-Soviet Internet reveals that the digital representation of cats is primarily shaped by human characteristics, rather than those inherent to the animal itself. This gives the digital cats a subjectivity that is more akin to that of humans. The increasing anthropomorphisation of cats and the felinization of humans has resulted in the emergence of a dystopian world characterised by the “cat police”. In this context, the cat assumes a more prominent role than its human counterpart, thereby conferring upon it the authority to exercise control and impose punishment. However, the methods of control and punishment employed by the “koshchichkina” remain flexible and adaptable to changing corporeality and sensuality, expressed through ironic memes, short videos and clips. The findings of this research can be incorporated into an interdisciplinary study of the mechanisms of identity formation of the modern man and the formation of a new canon of his sensuality and corporeality.
Hubungan Pola Makan dan Aktivitas Fisik Terhadap Dismenore Pada Siswi SMP Al-Farabi
Authors: Assari Dita , Nila Sari Fitri Dian , Harahap Siti Nurlani , Tamara Chatrine Virginia 
Published: December 2024

Dismenore adalah rasa nyeri pada bagian perut bawah yang dirasakan ketika sedang menstruasi. Penelitian ini bertujuan untuk mengetahui hubungan yang signifikan antara pola makan terhadap dismenore, mengetahui hubungan yang signifikan antara aktivitas fisik terhadap dismenore, mengetahui hubungan yang signifikan antara pola makan dan aktivitas fisik terhadap dismenore pada siswi SMP kelas VII Al-farabi. Metode yang digunakan dalam penelitian ini adalah metode deskriptif analitik dengan desain penelitian cross sectional. Metode pengumpulan data yang digunakan adalah kuesioner (angket) dan dokumentasi secara langsung. Dari penelitian yang dilakukan maka diperoleh hasil penelitian responden berumur 12 tahun sebanyak 30 orang (5,45%), umur 13 tahun sebanyak 24 orang (4,36%) dan 14 tahun sebanyak 1 orang (0,18%). Tingkat aktivitas fisik tidak baik sebanyak 37 orang (67,3%), pola makan responden yang tidak baik sebanyak (29 orang (52,7%), dan keluhan dismenore berat sebanyak 51 orang (92,7%). Tidak ada hubungan antara pola makan terhadap dismenore yang ditunjukkan dengan nilai p(0,611)>0,05, tidak ada hubungan antara aktivitas fisik terhadap dismenore dengan nilai p(1)>0,05.
Penguatan Peran Polri dalam Menanggulangi Intoleransi dan Radikalisme Guna Mencegah Terorisme Tahun 2023
Authors: Saputra Azis , Dadang Sutrasno  , Widi Setiawan  
Published: December 2024

Indonesia sebagai negara majemuk memberikan perhatian cukup luas terhadap kehidupan beragama. Indonesia merupakan negara berdasarkan Pancasila dan sebagai religious nation state, yaitu negara kebangsaan yang melindungi dan memfasilitasi seluruh agama warga negaranya. Untuk menjaga harmonisasi kehidupan beragama, Indonesia memiliki peraturan perundang-undangan yang mendorong kehidupan yang toleran, menjamin hak-hak kemerdekaan beragama, melarang ujaran kebencian dan untuk menangani terorisme. Namun, sejak era reformasi sampai saat ini, kerukunan dan kebebasan beragama sering terganggu oleh aksi kelompok intoleran dan radikal yang memahami perbedaan agama secara tidak tepat. Oleh karena itu, Puslitbang Polri perlu melakukan penelitian tentang Penguatan Peran Polri dalam Menanggulangi Intoleransi dan Radikalisme guna Mencegah Terorisme. Penelitian ini menggunakan metode kualitatif dan kuantitatif. Responden terdiri dari masyarakat dan personel Polri di Tingkat Polres. Hasil penelitian menyebutkan: 1)Situasi kerukunan antar umat beragama di sepuluh lokasi penelitian menunjukkan situasi yang relatif kondusif; 2)Sebagian besar wilayah, penanganan intoleransi, radikalisme dan terorisme belum menjadi prioritas, baik bagi internal anggota Polri maupun para tokoh masyarakat dan pemerintah daerah; 3)Kasus intoleransi yang paling menonjol dan banyak ditemui di lokasi penelitian (masyarakat) adalah: penolakan rumah/tempat ibadah, penolakan kegiatan/ritual keagamaan tertentu dan penistaan agama; 4)Potensi radikalisme oleh eks-napiter yang belum kembali ke NKRI juga masih menjadi persoalan tersendiri; 5)Secara umum, peran serta masyarakat guna mencegah intoleransi dan radikalisme dapat dilihat dari dua aspek, yaitu kultural dan struktural; 6)Sejauh ini hanya polres-polres yang memiliki eks-napiter di wilayahnya saja yang mendapatkan anggaran untuk pembinaan/penggalangan eks-napiter.
Macroeconomic Challenges in Mortgage Accessibility for Emerging Markets
Authors: Yarnykh Elvira , Lebedinskaya Olga , Sadovnikova Natalia , Popova Galina , Bezrukov Alexander 
Published: December 2024

Objective: The article discusses issues related to the development of the residential real estate market as an independent part of the market economy associated with solving the acute problem of providing housing to the population of the country. The development of the residential real estate market is accompanied by a rapid increase in housing prices against the background of a decrease in the solvency of the population and the volume of commissioning of residential buildings. The result of these processes was the revival of housing mortgage lending (HLS). The main purpose of this study is to develop and improve the methodological aspects of quantitative analysis of housing mortgage lending.

Theoretical Framework: The theoretical and methodological basis of the research was the works of domestic and foreign scientists on statistics, finance and lending, legislative acts and regulatory documents of government bodies, official information and statistical data of the Federal State Statistics Service (Rosstat), the Central Bank of the Russian Federation (CBR), commercial banks, as well as research of scientific institutions.

Method: In solving the tasks set, modern statistical scientific apparatus and research methods were used: tabular and graphical analysis, comparative analysis, correlation analysis, time series analysis, multidimensional statistical analysis, including the iterative method of cluster analysis.

Results and Discussion: The The result of the study is a spatial typological grouping of the subjects of the Russian Federation by the level of mortgage housing lending, as well as the identification of the influence of macroeconomic factors on the volume of mortgage housing lending in Russia.
The Role of Leukocyte Telomere Length in Cognitive Function, Symptom Severity, and Sdg-Related Health Goals Among Batak Schizophrenia Patients
Authors: Husada Muhammad Surya , Rambe Aldy Safruddin , Effendy Elmeida , Ichwan Muhammad , Malik Khamelia , Munir Delfitri , Surbakti Khairul Putra , Amin Mustafa Mahmud 
Published: December 2024

Objective: To assess the relationship between leukocyte telomere length, cognitive function, and symptom severity in Batak tribe schizophrenia patients, with a focus on telomere length as a potential biomarker for disease progression and its relevance to Sustainable Development Goal (SDG) 3: Good Health and Well-being.

Theoretical Framework: This study builds on findings linking leukocyte telomere shortening to accelerated aging, cognitive decline, and increased risks of neurodegenerative diseases and cancer. These connections underscore the importance of telomere length as a marker of symptom severity in schizophrenia and its alignment with global health objectives under the SDGs.

Method: A 6-month cross-sectional study design with numerical correlation tests was used from January to June 2023. Eighty-five patients from the Batak tribe diagnosed with schizophrenia were recruited from Regional Mental Hospital Prof. Dr. M. Ildrem Medan, and telomere length analysis was conducted at Prodia Private Clinical Laboratory in Medan.

Results and Discussion: The sample included 85 patients, mostly male (80%) with a mean age of 30.38 years (SD: 3.2). Cognitive function showed a mean MoCA-Ina score of 17.33 (SD: 5.4), and symptom severity showed a mean PANSS score of 48.87 (SD: 9.73). Leukocyte telomere length ratios were 0.92 (SD: 0.04) for β-globin T/S and 0.99 (SD: 0.05) for B4AU T/S. No significant link was found between telomere length and cognitive function (p>0.05), but shorter telomeres correlated with more severe symptoms (β-globin T/S: p=0.034, r=-0.23; B4AU T/S: p=0.037, r=-0.227).

Research Implications: Findings indicate that leukocyte telomere length could serve as a biomarker for schizophrenia symptom severity, offering valuable insights for disease progression and contributing to health monitoring strategies aligned with SDG 3.

Originality/Value: By focusing on the Batak tribe, this study highlights telomere length as a biomarker for prognosis and underscores the importance of diverse population studies to achieve SDG-related health outcomes.
Effect of nimbolide on rat spermatozoa under in-vitro condition: A study on sperm functional events and antioxidants during capacitation
Authors: NT Chaitra , Aladakatti Ravindranath H , B P Nandeshwarappa 
Published: December 2024

However, little evidence has been documented to evaluate the clear specific effects of neem-active ingredients in a rat model. This study aims to evaluate the in vitro effects of nimbolide (tetranortriterpenoids group, one of the main components of neem leaves), particularly on sperm functional studies, and biochemical and molecular events during capacitation in a dose dependent manner. The results showed a dose- and time-dependent decrease in the functional consequence of capacitation process i.e., motility score, percentage of motile spermatozoa, Sperm Motility Index (SMI) and levels of molecular events in sperm followed by declined spontaneous acrosome reaction (AR), which subsequently leads to lesser binding of cauda epididymal sperm to the Zona pellucida (ZP). Biochemical studies have shown that the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase, Glutathione reductase (GR) and Glutathione peroxidase (GPx) decreased significantly while the levels of Hydrogen peroxide (H2O2) generation and lipid peroxidation (LPO) increased significantly in the treated groups indicating nimbolide-induced oxidative stress in rat epididymal sperm. This study confirmed that nimbolide convincingly inhibited sperm motility in rats by blocking certain biochemical pathways, such as energy utilization, and showed that sperm capacitation was associated with a reduction in AR, with changes in antioxidant enzymes reflecting a reduction at the levels of molecular events. This will lead us to produce a special product as a source of a new male contraceptive.
ПЕРСПЕКТИВЫ УТИЛИЗАЦИИ ОТХОДОВ ДОБЫЧИ ИЗВЕСТНЯКА-РАКУШЕЧНИКА ПУТЕМ ПЕРЕРАБОТКИ В НОВЫЕ МАТЕРИАЛЫ
Authors: Букаев Е.З. , Нурбаева Ф.К. , Муралев Е.Д. 
Published: December 2024

Добыча известняка-ракушечника имеет значение для строительства благодаря прочности и экологичности материала. Этот известняк, богатый карбонатом кальция (CaCO₃), применяется для облицовочных и строительных блоков. Однако его добыча сопровождается экологическими рисками: изменением ландшафта, загрязнением, разрушением экосистем и образованием отходов. В работе исследуется возможность переработки отходов известняка для строительства. Испытания материалов на основе карбонатных отходов с добавлением органических компонентов показали их пригодность. Внедрение таких технологий снижает строительные затраты и уменьшает экологическое воздействие
Әктас-ұлутасты өндіру құрылыс үшін материалдың беріктігі мен экологиялық тазалығына байланысты маңызды. Кальций карбонатына (CaCO₃) бай бұл әктас қаптамалық және құрылыс блоктарын жасауға қолданылады. Алайда, оның өндірісі ландшафттардың өзгеруі, ластануы, экожүйелердің бұзылуы және қалдықтардың жиналуын қоса алғанда, экологиялық қауіптермен қатар жүреді. Бұл жұмыста әктастың қалдықтарын құрылысқа қайта өңдеу мүмкіндігі қарастырылады. Органикалық компоненттер қосылған карбонаттық қалдықтар негізіндегі материалдарды сынау олардың жарамдылығын көрсетті. Мұндай технологияларды енгізу құрылыс шығындарын азайтып, экологиялық әсерді төмендетед
The extraction of limestone shell rock is important for construction due to the material’s strength and eco-friendliness. This limestone, rich in calcium carbonate (CaCO₃), is used for cladding and construction blocks. However, its extraction poses environmental risks, including landscape alteration, pollution, ecosystem destruction, and waste generation. This study explores the potential for recycling limestone waste for construction. Tests of materials based on carbonate waste with added organic components demonstrated their suitability. The implementation of such technologies reduces construction costs and minimizes environmental impact
ФОРМИРОВАНИЕ И ПЕРСПЕКТИВЫ АРХАРЛИНСКОГО ЗОЛОТОРУДНОГО УЗЛА
Authors: Жолтаев Г.Ж. , Умарбекова З.Т. , Минискул Ш.Д. , Аманбаев Р.А. 
Published: December 2024

В статье анализируется формирование и геологическое строение Архарлинского золотоносного рудного узла; разбито на 6 этапов, каждый из которых отражает специфические вулканические и магматические процессы. Описана структура рудного узла и его историческое развитие, что позволяет выделить ключевые этапы формирования и типы минерализации. Обсуждаются перспективы дальнейшего изучения площади, включая выявление новых рудных зон, таких как Иглик и Малайсары, а также доразведка глубоких горизонтов и флангов известных месторождений. В статье подчеркивается, что перспективы всего Архарлинского рудного узла могут быть значительно улучшены благодаря более детальному исследованию и актуализации геологических данных. В отличие от других исследований, сосредоточенных на конкретных аспектах месторождения Архарлы, данный обзор предоставляет более широкий взгляд на потенциал всего рудного узла
Мақалада Архарлы алтын кені түйінінің қалыптасуы мен геологиялық құрылымы талданған, ол әртүрлі вулкандық және магмалық процестерді көрсететін алты кезеңге бөлінген. Кен түйінінің құрылымы және оның тарихи дамуы сипатталады, бұл негізгі қалыптасу кезеңдері мен минералдану түрлерін анықтауға мүмкіндік береді. Мақалада аймақты одан әрі зерттеу перспективалары, соның ішінде Іглік пен Малайсары сияқты жаңа кен орындарын анықтау, сондай-ақ белгілі кен орындарының терең көкжиектері мен қанаттарын қосымша барлау мәселелері талқыланады. Сонымен қатар, Архарлы кен түйінінің әлеуетін неғұрлым егжей-тегжейлі зерттеу және геологиялық деректерді жаңарту арқылы айтарлықтай жақсартуға болатыны атап өтілген. Басқа зерттеулерден айырмашылығы, бұл шолу Архарлы кен орнының нақты аспектілеріне назар аудармай, бүкіл кен түйінінің әлеуетіне кеңірек көзқарас ұсынады
The article analyzes the formation and geological structure of the Arkharlin gold-bearing ore knot, breaking it down into six stages, each refl ecting specific volcanic and magmatic processes. The structure of the ore knot and its historical development are described, allowing the identifi cation of key stages of formation and types of mineralization. The article discusses the prospects for further exploration of the area, including the identifi cation of new ore zones such as Iglik and Malay-Sary, as well as the additional exploration of deep horizons and the fl anks of known deposits. It emphasizes that the potential of the entire Arkharlin ore knot could be signifi cantly enhanced through more detailed research and the updating of geological data. Unlike other studies focused on specifi c aspects of the Arkharlin deposit, this review provides a broader perspective on the potential of the entire ore knot