bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near-Infrared Fluorescent Agent for In Vitro Screening of Endometrial Cancer and Precancerous Lesions
Authors: Liang Dongxin , Tuo Xiaoqian , Wang Qing , Zhao Lanbo , Zhang Kailu , Wang Yiran , Feng Xue , Yin Panyue , Guo Lin , Liu Yu , Wang Lei , Han Lu , An Ruifang , Li Qiling 
Published: July 2021

The lack of cytopathologists delays the advancement of screening for endometrial cancer. It was urgent to develop a new dye for rapid diagnosis. Our study aimed to synthesize a targeted folate receptor-α near-infrared (NIR) fluorescent agent, folic acid-zwitterionic NIR fluorophore (ZW-FA), and explore the feasibility for screening of endometrial cancer and precancerous change. Folic acid was conjugated with zwitterionic NIR fluorophore. The preparation of ZW-FA was validated by 1H NMR, mass spectrometric, ultraviolet spectra and fluorescence spectra. ZW-FA was incubated with endometrial cytology samples obtained from patients who underwent dilation and curettage or total hysterectomy. Diagnostic utility was calculated by applying laser confocal microscope, Image-J and statistical models, such as enumeration, receiver operating characteristic curve, logistic regression, support vector machine and decision tree were used. The purity of ZW-FA was &gt; 95% determined by 1H NMR. ZW-FA had the strongest absorption peak at 633 nm in ultraviolet spectra. Photostability of ZW-FA was over 8 hours. In clinical validation, a total of 92 patients were enrolled. The cut-off value of ZW-FA was 49 in enumeration, which was used to distinguish the type of samples. Indicators about diagnostic utility are as follows: sensitivity 90.77%, specificity 62.96%, false-positive rate 37.04%, false-negative rate 9.23%, positive predictive value 85.51% and negative predictive value 73.91%. The samples processed by ZW-FA did not affect further Hematoxylin-Eosin staining and pathological diagnosis. It was an effective cytologic strategy for in vitro diagnosis of endometrial cancer and precancerous change by using ZW-FA.Clinical Trial Registrationhttp://www.chictr.org.cn/index.aspx, identifier ChiCTR1800020123.
Model-Based Meta-Analysis in Psoriasis: A Quantitative Comparison of Biologics and Small Targeted Molecules
Authors: He Huan , Wu Wenwen , Zhang Yi , Zhang Meng , Sun Ning , Zhao Libo , Wang Xiaoling 
Published: July 2021

Background: The response time-course information of biologics and small targeted molecules for the treatment of moderate to severe plaque psoriasis which helps clinicians to understand the onset of action and maintenance of effect are unclear. Quantitative information about the efficacy comparation of different systemic agents are needed.Methods: Model-based meta-analysis was conducted and longitudinal models were developed by applying two clinical end points commonly reported in the clinical trials of psoriasis: the proportion of patients achieving ≥75% reduction from baseline Psoriasis Area and Severity Index score (PASI75) and the proportion of patients achieving ≥90% reduction from baseline Psoriasis Area and Severity Index score (PASI90).Results: A total of 80 trials of thirteen biological agents and four small targeted molecules covering 235 treatment arms and 40323 patients with moderate to severe plaque psoriasis were included in this analysis. The drugs were divided into five classes of biologics and three classes of small molecules. Two longitudinal models of PASI75 and PASI90 were used to describe the time-varying drug effect and dose-effect relationship. The typical response-time courses for PASI75 and PASI90 increased over time and finally reached to the platform. For PASI75 end point at week 12, of all the therapeutic drugs, risankizumab administered as 150 mg at week 0, week 4, and q12w showed the most efficacious with PASI75 was 85.95% (95%CI, 75.71–92.60%), followed by ixekizumab administered as 160 mg at week 0, and q4w with PASI75 was 85.9% (95%CI, 76.12–92.79%). As for PASI90 end point at week 12, ixekizumab 160 mg at week 0, and q4w showed the greatest percentage of person achieved PASI90 (67.2%; 95%CI, 49.91–77.2%), followed by risankizumab 150 mg at week 0, week 4, and q12w (65.5%; 95%CI, 47.8–75.7%). What’s more, the risankizumab provided the highest response of PASI90 at week 16 and week 24.Conclusions: This study provided a quantitative efficacy comparation of 17 systemic agents for psoriasis in term of efficacy only and that safety was not considered. Risankizumab and ixekizumab showed superiority for both the two end points.
Comparative Efficacy and Acceptability of Anti-inflammatory Agents on Major Depressive Disorder: A Network Meta-Analysis
Authors: Hang Xiaoyi , Zhang Yijie , Li Jingjing , Li Zhenzhen , Zhang Yi , Ye Xuanhao , Tang Qisheng , Sun Wenjun 
Published: July 2021

Background: With the growing importance of research about the association between neuroinflammation and major depressive disorder (MDD), anti-inflammatory agents have been used as a new antidepressant therapy in clinical practice. We conducted a network meta-analysis (NMA) with up-to-date evidence to compare different anti-inflammatory agents for improving the treatment of MDD patients.Methods: To identify eligible randomized clinical trials, four databases (i.e, the Cochrane Library, Web of Science, PubMed and Embase) were searched from inception date to May 31, 2020. Anti-inflammatory agents were defined as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, cytokine inhibitors, statins, pioglitazone, minocycline, N-acetylcysteine (NAC) and omega-3 fatty acid (Omega-3 FA). The main outcomes of this NMA were efficacy, acceptability and remission rate. Risk ratio (RR) was adopted for dichotomous outcomes, and the confidence interval (CI) was set at 95%. STATA 14.0 and R 3.6.3 were used to conduct the NMA. The study protocol was registered with PROSPERO (CRD42020182531).Results: A total of 39 studies, involving 2871 participants, were included in quantitative data synthesis. For efficacy, NSAIDs (RR=0.50, 95%CI: 0.26-0.73) and pioglitazone (RR=0.45, 95%CI: 0.20-0.84) were more favorable than placebo. With respect to acceptability, NSAIDs were more acceptable than placebo (RR=0.89, 95%CI: 0.77-0.99) and minocycline (RR=1.22, 95%CI: 1.03-1.49). For remission, NSAIDs were more superior than placebo (RR=0.48, 95%CI: 0.27-0.79) and Omega-3 FA (RR=2.01, 95%CI: 1.09-3.90), while NACs were more favorable than placebo (RR=0.39, 95%CI: 0.13-0.99). Based on the surface under the cumulative ranking curve (SUCRA) value, corticosteroids (0.86) were the best anti-inflammatory agent for MDD patients in terms of efficacy, but the head-to-head comparisons for the efficacy of glucocorticoids and other agents were not statistically significant. As for acceptability, NSAIDs (0.81) were much better than other anti-inflammatory agents. Besides, NAC (0.80) was the best anti-inflammatory agent in the terms of remission.Conclusions: In summary, we found that corticosteroids were more superior than other agents in terms of efficacy according to the SUCRA value. However, this result must be interpreted with caution because the head-to-head comparisons for the efficacy of glucocorticoids and other agents did not reach statistical significance. NSAIDs were recommended for acceptability and NAC for remission rate.
Sleep, Anxiety, and Academic Performance: A Study of Adolescents From Public High Schools in China
Authors: Zhang Xiaoning , Dimitriou Dagmara , Halstead Elizabeth J. 
Published: July 2021

Purpose: Sleep is essential for optimal learning across the developmental pathways. This study aimed to (1) explore whether school start and end times and screen time influenced sleep disturbances in adolescents during the lockdown in China and (2) investigate if sleep disturbances at night and sleep-related impairment (daytime fatigue) influenced adolescents' academic performance and anxiety levels.Methods: Ninety-nine adolescents aged 15–17 years old were recruited from two public schools in Baishan City Jilin Province, China. An online questionnaire was distributed including questions on adolescents' demographics, screen time habits, academic performance, anxiety level, sleep disturbances, and sleep-related impairment.Results: Adolescents who started school earlier and ended school later had a greater severity of sleep disturbances and sleep-related impairment compared with students who started school later and finished earlier. Adolescents who engaged in screen time at bedtime were more likely to have a greater severity of sleep-related impairment than students who reported no screen time use at bedtime. Adolescents who had a greater severity of sleep disturbances had higher anxiety and higher academic achievements than adolescents with less sleep disturbances. Finally, 79.7% of adolescents reported their total sleep duration as &lt;8 h.Conclusions: Adolescents are experiencing sleep disturbances to manage academic demands during COVID-19, which in turn is having a wider impact on their mental health. Many schools internationally have continued to provide online education to students, longitudinal studies on how COVID-19 has influenced adolescents sleep and mental health would be beneficial in understanding the impact of the pandemic.
Population-Based Prevalence of Oral Conditions as a Basis for Planning Community-Based Interventions: An Epidemiological Study From Rural Burkina Faso
Authors: Clauss Alexandra , Sie Ali , Zabre Pascal , Schmoll Jörg , Sauerborn Rainer , Listl Stefan 
Published: July 2021

Objectives: The purpose of the present study was to: (i) provide timely data on dental caries and periodontal conditions in rural Burkina Faso; (ii) identify the oral health practices carried out in this population, and (iii) to prioritize evidence-based interventions at the community level.Methods: Leaning on WHO recommendations for oral health epidemiological studies, clinical examinations and questionnaire-based surveys were conducted in two different age groups (adolescents: 15–19 years old; adults: 35–44 years old) in the health district of Nouna, Burkina Faso. Caries and tooth status were assessed according to the DMFT Index. The periodontal status was assessed by a modified Community Periodontal Index on all teeth present and measuring the level of attachment-loss of six index teeth. Questionnaire items specifically included utilization of oral health care and oral health behaviors.Results: The prevalence of untreated caries was 38% in adolescents and 73% in adults. In terms of periodontal health, 21% of adolescents and 61% of adults had an attachment loss ≥4 mm. Ninety seven percent of adolescents had not attended a dentist in the previous year and 78% of adults had never seen a dentist in their life. About one third of adolescents and adults cleaned their teeth less often than once per day with equal proportions of toothbrushes and traditional chewing sticks made of tree branches. Fluoride toothpaste was used by &lt;10% of study participants. Almost half of the examined people reported to drink a sugar-sweetened beverage at least once a day.Conclusions: Dental caries and periodontitis are highly prevalent in rural Burkina Faso. These findings highlight the key relevance of epidemiological data for identifying people's oral health needs as basis for developing, testing, and implementing oral health interventions and programs. Special emphasis should be put on the design and evaluation of community-based interventions.
Acute Effects of Pimobendan on Cardiac Function in Dogs With Tachycardia Induced Dilated Cardiomyopathy: A Randomized, Placebo-Controlled, Crossover Study
Authors: Abbott-Johnson Kaitlin , Pierce Kursten V. , Roof Steve , Rio Carlos L. del , Hamlin Robert 
Published: July 2021

Background: Pimobendan provides a significant survival benefit in dogs with cardiac disease, including degenerative mitral valve disease and dilated cardiomyopathy (DCM). Its positive inotropic effect is well-known, however, it has complex effects and the mechanisms behind the survival benefit are not fully characterized. Secondary hemodynamic effects may decrease mitral regurgitation (MR) in DCM, and the benefits of pimobendan may extend to improved cardiac relaxation and improved atrial function.Hypothesis/Objectives: Our objective was to investigate the acute cardiac effects of pimobendan in dogs with a DCM phenotype. We hypothesized that pimobendan would increase left atrial (LA) contractility, reduce mitral regurgitation, improve diastolic function, and lower circulating NT-ProBNP levels.Animals: Seven purpose-bred Beagles were studied from a research colony with tachycardia induced DCM phenotype.Methods: The effects of pimobendan were studied under a placebo-controlled single-blinded cross-over design. In short, dogs underwent baseline and 3 h post-dose examinations 7 days apart with echocardiography and a blood draw. Dogs were randomized to receive oral placebo or 0.25 mg/kg pimobendan after their baseline exam. Investigators were blinded to treatments until all measurements were compiled.Results: When treated with pimobendan, the dogs had significant increases in systolic function and decreases in MR, compared to when treated with placebo.There were no detectable differences in left atrial measures, including LA size, LA emptying fraction, LA functional index or mitral A wave velocity. Heart rate decreased significantly with pimobendan compared to placebo. There was also a decrease in isovolumetric relaxation time normalized to heart rate. NT-proBNP levels had a high degree of variability.Conclusions: Improved mitral regurgitation severity and improved lusitropic function may contribute to the reported survival benefit for dogs with cardiac disease administered pimobendan. Pimobendan did not overtly improve LA function as assessed by echocardiography, and NT-proBNP was not significantly changed with a single dose of this medication. Further studies are needed to better characterize LA effects with other imaging modalities, to better quantify the total improvement of MR severity, and to assess chronic use of pimobendan on diastolic function in DCM.
Action de l'éther-oxy-ricinoléique de polyéthylène glycol (600) sur les membranes cellulaires
Authors: Bocquet Roger 
Published: July 2021

The ether-oxy-ricinoleique de polyethylene glycol (6000) (EOR-PEG) has already been subject to a communication on the 7th of June 1979, in which the selective eradication of B lymphocytes, has been proved.
It had been infered from it, that it would be interesting, to study the effect of this product on the cells membranes.
It’s the subject of this communication. The EOR-PEG has been challenged by acting both on cells cultures, either cancerous (HeLa cells) or not cancerous (Vero cells).
The various results observed, confirm the fact that the EOR-PEG 6000 acts in different way following, the previous differences in the membranes constitution, lymphocytes B and cancerous cells showing a very particular sensibility and vulnerability.
Le tombeau des Tite Vesi à Pérouse. Microcosme familial et culture hellénistique
Authors: Massa-Pairault Françoise-Hélène 
Published: July 2021

L’examen des monuments funéraires trouvés au XVIe siècle dans le tombeau des Tite Vesi à Pérouse conduit à une enquête approfondie sur l’une des familles les plus importantes de la cité étrusque à l’époque hellénistique (IIe -Ier siècles av. n. è.).
L’analyse du style et de la typologie des monuments funéraires, ainsi que l’étude des inscriptions conservées, permettent en effet de restituer partiellement la chronologie relative des monuments, l’arbre généalogique de la famille et le cercle de ses alliances matrimoniales, démontrant son poids social et politique. Elles permettent en outre d’éclairer les rapports de la famille avec certains ateliers de sculpteurs d’urnes funéraires ainsi que les raisons du choix de certains thèmes mythologiques. Une analyse est consacrée tout spécialement à la scène dite «Monstre sortant du puteal » interprétée comme une illustration de la légende d’Ulysse au pays des Thesprotes et des Molosses.
L’étude de ce microcosme familial révèle ainsi la situation des élites de Pérouse à l’époque hellénistique, partagées entre la contemplation nostalgique de personnages évoquant les origines étrusques (Ulysse l’Errant) et le désir d’agrégation au monde politique de Rome et de ses colonies (notamment Pisaurum) sur l’Adriatique.
Les rois maures et les Îles Purpuraires (Mogador)
Authors: Jodin André 
Published: July 2021

Sur la côte atlantique du Maroc, les îlots de Mogador fixent la latitude la plus méridionale jamais atteinte par les navigateurs antiques. L’intérêt qu’ils portaient à ces parages est dû à une exceptionnelle richesse en produits de la mer : thons, poissons de toutes espèces fournissant du garum, murex traité dans les pourpreries locales.
Dès le VIIe siècle, les Phéniciens avaient ouvert la voie, mais à l’époque punique les rois maures (tel Bocchus l’Ancien) exploitaient à Mogador ces produits dans un véritable «complexe industriel» dont ils tiraient la majeure partie de leurs ressources financières. En effet, les fouilles ont révélé que longtemps avant le roi Juba II, protégé d’Auguste, un bâtiment assez luxueux avait été construit dès le début du IIe siècle avant notre ère, comprenant notamment une grande citerne naviforme de conception punique, telle qu’on en connaît à Carthage.
The level of physical activity for hypertensive and diabetic patients and the damage caused by the physical exercise requirement / O nível de actividade física para doentes hipertensos e diabéticos e os danos causados pela necessidade de exercício físico
Authors: Nunes Grace Fernanda , Duarte José Alberto R. , Dutra Maurilio Tiradentes , Bovolini Antonio , Duarte Michelle Matos , Martin Luis Cuadrado 
Published: July 2021

Physical exercise has been identified as a major non-pharmacological agent, assuming a protective role in the treatment of chronic non-communicable diseases, especially in hypertension and diabetes mellitus. The levels of physical activity as well as its intensity are of great impact for the full benefits to come of this practice. We know that the level of physical activity is a relevant factor for maintaining good health, however, little attention has been paid to what is established in relation to high-intensity daily exercise adjusted to cardiac damage or adaptation. The objective was to reflect on the prescription of physical activity in the treatment of hypertensive and diabetic patients and how eccentric exercise is related to the cardiomyocyte tissue in the damage process. We observed that the highest level of physical activity was associated with better quality of life, and that active patients have an 80% chance of survival when compared to sedentary ones. Thus, despite the potential benefits from the metabolic point of view, public health efforts should also focus on maintaining and protocols of physical activity levels since our study showed that intense eccentric physical activity had harmful effects at the cardiac level.
Avaliação do consumo de ultraprocessados por idosos com depressão em tratamento terciário para doenças cardiovasculares
Authors: Bandeira Filho Orlando Carvalho de Sousa , do Vale Flávia Rodrigues , Marotto Deborah , de Paula Laís Silva , Peçanha Daniela Olegário , dos Santos Elisa Maia , Huguenin Grazielle Vilas Bôas , Moreira Annie Seixas Bello 
Published: July 2021

Introdução: A depressão caracteriza-se por um distúrbio de natureza multifatorial da área afetiva ou do humor. É uma doença de saúde mental que pode diminuir a qualidade de vida, prejudicar a vida social e desenvolver outras complicações. O indivíduo depressivo pode estar mais suscetível ao consumo de ultraprocessados por ser uma alimentação prática, rápida e de maior palatabilidade, diminuindo o tempo destinado para a alimentação e ao mesmo tempo satisfazendo o paladar. Objetivo: Avaliar o consumo de alimentos ultraprocessados em idosos com depressão em tratamento terciário para doença cardiovascular. Métodos: Estudo transversal com 179 indivíduos de ambos os sexos, com idade a partir de 60 anos com histórico de evento cardiovascular, participantes do Estudo Multicêntrico Dieta Cardioprotetora Brasileira (DICA/BR) realizado no ambulatório de Cardiologia da Policlínica Piquet Carneiro (UERJ) e do ambulatório do Instituto Nacional de Cardiologia (INC). Foram submetidos à avaliação dietética através do Recordatório de 24 horas, e avaliação de depressão através do questionário Center for Epidemiologic Studies-Depression scale- (CES-D Scale). As análises dietéticas foram realizadas através do programa NUTRIQUANTI® e as análises estatísticas foram feitas através do programa SPSS versão 21 e aplicados teste T student, teste Mann Whitney U e Correlação de Pearson, nível de significância < 0,05. Resultados: O gênero masculino correspondeu a maior parte da população (61,5%). Em relação à população total, 39% foram indicativo de depressão com 14 (8 – 20) pontos no questionário CES-D Scale. A contribuição calórica do VET (valor energético total) de alimentos in natura ou minimamente processados constou de 67,73% (51,43 – 77,06), alimentos processados de 18,54% ± 12,78 e alimentos ultraprocessados de 16,63% (8,95 – 28,13) sem diferença significativa entre os grupos (p>0,05). Não houve correlação entre o consumo de alimentos processados ou ultraprocessados com o escore de depressão dos idosos. Conclusão: Os resultados do presente estudo evidenciaram presença de um moderado consumo de alimentos ultraprocessados por idosos em tratamento terciário para doença cardiovascular com depressão. Porém, faz-se necessário a realização de mais estudos.
ГЕНДЕРНІ ОСОБЛИВОСТІ ЕМОЦІЙНОГО ІНТЕЛЕКТУ ДІТЕЙ З ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ
Authors: Коць Михайло , Ващеня Ганна , Кузьмич Олена 
Published: July 2021

У статті здійснено теоретичний аналіз та емпіричне дослідження емоційного інтелекту дітей з особливими освітніми потребами.
Зазначається, що для успішної соціалізації дітей з особливими освітніми потребами одним із ключових чинників є рівень сформованості емоційної сфери. Обґрунтовується важливість того, як за допомогою емоцій і почуттів дитина сприймає навколишній світ і водночас свій внутрішній світ та володіє здібностями емоційного інтелекту як запорукою успішного майбутнього життя.
У результаті емпіричного дослідження гендерних відмінностей емоційного інтелекту дітей з особливими освітніми потребами встановлено, що загальний рівень емоційного інтелекту не характеризується відмінностями між групами вибірки. У хлопців і дівчат переважають показники низьких та середніх рівнів розвитку емоційного інтелекту. Показники внутрішньо-особистісного емоційного інтелекту демонструють, що в більшості хлопців переважає середній його рівень розвитку, а у більшості дівчат – на дуже низькому рівні розвитку. Показники міжособистісного емоційного інтелекту вказують на низький та дуже низький рівень його розвитку, як у більшості дівчат, так і хлопців.
Гендерні відмінності наявні в структурних компонентах емоційного інтелекту. Так, у вибірці дівчат переважають здібності до емпатії, здатність управляти емоційними проявами. У вибірці хлопців переважають здібності до розуміння своїх емоцій, здатність використовувати емоції в діяльності, керувати чужими емоціями.