bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of persistent ventricular dilation by initial ventriculomegaly and clot volume in a porcine model
Authors: Lai Grace Y. , Chu Kwan William , Piorkowska Karolina , Wagner Matthias W. , Jamshidi Pouya , Ertl-Wagner Birgit , Looi Thomas , Waspe Adam C. , Drake James M. 
Published: November 2021

OBJECTIVE
While intraventricular hemorrhage (IVH) is associated with posthemorrhagic ventricular dilation (PHVD), not all infants affected by high-grade IVH develop PHVD. The authors aimed to determine clot-associated predictors of PHVD in a porcine model by varying the amount and rate of direct intraventricular injection of whole autologous blood.

METHODS
Seven 1-week-old piglets underwent craniectomy and injection of autologous blood into the right lateral ventricle. They survived for a maximum of 28 days. MRI was performed prior to injection, immediately postoperatively, and every 7 days thereafter. T1-weighted, T2-weighted, and susceptibility-weighted imaging (SWI) sequences were used to segment ventricular and clot volumes. Spearman correlations were used to determine the relationship between blood and clot volumes and ventricular volumes over time.

RESULTS
The maximum ventricular volume was up to 12 times that of baseline. One animal developed acute hydrocephalus on day 4. All other animals survived until planned endpoints. The interaction between volume of blood injected and duration of injection was significantly associated with clot volume on the postoperative scan (p = 0.003) but not the amount of blood injected alone (p = 0.38). Initial postoperative and day 7 clot volumes, but not volume of blood injected, were correlated with maximum (p = 0.007 and 0.014) and terminal (p = 0.014 and 0.036) ventricular volumes. Initial postoperative ventricular volume was correlated with maximum and terminal ventricular volume (p = 0.007 and p = 0.014).

CONCLUSIONS
Initial postoperative, maximum, and terminal ventricular dilations were associated with the amount of clot formed, rather than the amount of blood injected. This supports the hypothesis that PHVD is determined by clot burden rather than the presence of blood products and allows further testing of early clot lysis to minimize PHVD risk.
Subject of the Church and State Relations in the Latest Russian Researches
Authors: Задорнов Александр 
Published: November 2021

В настоящем обзоре рассматриваются недавно изданные монографии, в которых отражаются государственно-конфессиональные отношения, и анализируются попытки вписать эти отношения в современные концепции государства и его происхождения. Критикуются методологические предпосылки такого анализа и подхода.
In the present review recently published monographs in which the state and confessional relations are reflected are considered and attempts to enter these relations in modern concepts of the state and its origin are analyzed. Methodological prerequisites of such analysis and approach are criticized.
Saint Savva and Slavic Peoples
Authors: Троицкий Сергей Викторович 
Published: November 2021

В 2019 году Сербская Православная Церковь празднует 800-летие своей автокефалии. В честь этого юбилея впервые публикуется русский перевод речи профессора С. В. Троицкого, посвящённой первому независимому главе Сербской Церкви - святителю Савве.
In 2019 the Serbian Orthodox Church celebrates the 800 anniversaries of the autocephaly. In honor of this anniversary Russian translation of the speech of professor S.V. Troitsky devoted to the first independent head of the Serbian Church - to the st. Savva is for the first time published.
Dapsone can be a new treatment option for reducing the detrimental effect of priapism
Authors: KÖLÜKÇÜ Engin , PARLAKTAŞ Bekir Süha , ULUOCAK Nihat , DERESOY Faik , UNSAL Velid , KATAR Muzaffer 
Published: November 2021

Aim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats.
Material and Method: A total of 24 rats were randomized into three groups. Group 1 was defined as the control group. Ischaemia-reperfusion injury was evaluated following the priapism model in Group 2. Group 3 had similar procedures to the rats in Group 2. Group 3 additionally had 12.5 mg/kg dapsone administered intraperitoneally 30 minutes after priapism.
Results: Biochemical analysis of blood indicated a significant increase in Group 3 in terms of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and total antioxidant status (TAS) values compared with Group 2 (p:0.002, p:0.029 and p:0.009, respectively). The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p
Clinical and prognostic evaluation of patients admitted to the COVID-19 pandemic unit of the emergency department
Authors: ÖZTÜRK DURMAZ Şenay , SÜMER COŞKUN Ayşenur , YALÇIN Ata Nevzat 
Published: November 2021

Objective: This study aimed to evaluate to prognosis of patients admitted to the COVID-19 isolation unit of the emergency department and present epidemiological data by examining their demographic, clinical, laboratory and lung tomography findings.
Material and Method: A total of 504 patients presenting with COVID-19 symptoms were randomly and retrospectively evaluated based on electronic records obtained from the hospital archive.
Results: Of the patients, 216 (42.9%) were female and 288 (57%) were male. The RT-PCR test was positive in 291 (57.7%) patients, and fever was the most common symptom in 280 (55.5%). A total of 133 patients (26.4%) were admitted to the inpatient ward. The WBC, Troponin-t, CRP, AST, ALT, LDH, D-dimer and ferritin levels were high and lymphocyte count was low in patients who were hospitalized. Sixty-one percent of the patients had a comorbid condition; 19% of had diabetes and 18.8% had hypertension as the most common underlying condition. Totally, 312 (61.9%) had favipiravir, 106 (21%) were favipiravir + hydroxychloroquine, 60 (11.9%) used hydroxychloroquine alone, 26 (5.2%) were followed up without treatment and to 147 of them, antibiotics were prescribed in addition to the medicine; 38.5% of the patients followed up in the intensive care unit were diabetic; 26 patients (5.2%) were followed up in the intensive care unit. The mortality rate was found to be 1.9%. At least one comorbid condition was present in all who were hospitalized and died in the intensive care unit.
Conclusion: The importance of a healthy diet and regular physical activity for metabolic conditions such as diabetes and hypertension as well as for fighting infections is well known. We consider that the mortality and morbidity rates due to the COVID-19 pandemic can be reduced by developing reliable and safe antiviral treatment options and implementing effective and fair vaccination policies.
Volumetric study of tracheal diverticulum: a retrospective analysis in computed tomography
Authors: GÜRÜN Enes , AKDULUM İsmail , KAYA Mustafa 
Published: November 2021

Aim: The aim of this study was to retrospectively evaluate the prevalence and morphology (location, diameter, number and volume) of the tracheal diverticulum (TD) on thoracic computed tomography (CT), in a sample of the Turkish population.
Material and Method: The study was conducted over 15 months, from February 2020 to April 2021, and included 3,860 thoracic CT scans, of which 1,891 subjects were men and the rest were women. All of the thoracic CT scans were evaluated retrospectively. All images were reviewed for the presence or absence of the TD in the axial plane, defined as air sacs around the trachea and communication with the trachea. For volume measurement, the TD contour was manually evaluated by a single radiologist, for all patients. Descriptive statistics were reported as mean±standard deviation (SD). A p value of less than 0.05 was considered significant.
Results: The mean age of the patients was 57.87±14.76 (29-84). In this study, the incidence of TD was calculated to be 0.80%. The mean tracheal diverticulum volume (TDV) and maximum transverse diameter (MTD) of TD were 983.62±1 509.80 mm3 and 8.79±6.19 mm, respectively.
Conclusion: In this study, we demonstrated the volumetric measurement of TD and its prevalence. We believe that the frequency of its use in clinical practice should increase, as volumetric measurements provide healthier results than diameter measurements.
Hypofractionated radiotherapy results of patients with malign glioma aged 60 and over
Authors: ERTAŞ Gülçin , ÜÇER Ali Rıza , AZAK Can , ALTUNDAĞ Muzaffer Bedri 
Published: November 2021

Aim: The aim of this study is to examine the treatment results of 25 malign glioma patients, aged >60 who underwent hypofractionated radiotherapy, respectively.
Material and Method: Total excision was applied to 14 of the patients, subtotal excision was applied to 5 and biopsy was applied only to 3. Three patients were evaluated as inoperable. Pathological diagnosis is compatible with glioblastoma in 22 patients, gliosarcoma in 2 patients and anaplastic astrocytoma in 1 patient. Hypofractionated radiotherapy was applied to all patients in the dose range 2.66-3.4 Gy x 10-15 fractions. Ten patients were treated concurrent temozolomide with radiotherapy and then 4-6 cures of adjuvant temozolomide. Only concurrent temozolomide treatment was applied to 3 patients, while only adjuvant temozolomide was applied to 4 patients.
Results: The median age is 72 years. (min 60–max 86) . The rate of patients with comorbid disease is 44%. The median follow-up period of the patients is 5 months (min 1-max 22). 6-months, 1-year, 18-months overall survival were 47%, 20%, 10%, respectively. Median survival in patients aged >70 is 3 months and 8 months in patients
Hypoechoic nodule structure increases non-diagnostic rate of thyroid fine needle aspiration biopsy
Authors: ÇETİN Zeynep 
Published: November 2021

Aim: Thyroid fine needle aspiration biopsy (FNAB) performed with ultrasonography is an effective method in diagnosing thyroid cancer. Nevertheless, some of them have non-diagnostic results. The aim is to investigate the factors that affect non-diagnostic result.
Material and Method: FNABs of 361 nodules of 361 patients were analyzed retrospectively. The patients were divided into two groups as fine needle aspiration biopsy result with and without non-diagnostic. The groups were compared according to demographic, clinical and sonographic data.
Results: Non-diagnostic rate was 14.4% in all biopsies. There was no difference in terms of age, gender, previous thyroid surgery history, smoking history, aspirin use, Hashimoto’s thyroiditis, toxic nodule. Sonographic findings of the thyroid glands and nodules were similar. Only the echogenicity of the nodule was found to affect the non-diagnostic result (p=0.015). In the post hoc analysis, the difference was found to be caused by hypoechoic nodules (32.7% versus 15.5). It was observed that the significant relationship found in univariate logistic regression analysis (p=0.009, OR: 3.227, CI: 1.334-7.803) continued in multivariate analysis (p=0.024, OR: 3.175, CI: 1.163-8.668).
Conclusion: Only hypoechoic echogenicity increases the risk of non-diagnostic rate. Other factors do not increase the non-diagnostic rate.
Distribution of clinical isolates obtained from sterile body fluids: a four-year retrospective data
Authors: ÇETİN DURAN Alev , KULA ATİK Tuğba , ÖZEN Nermin , SİG Ali Korhan , IRMAK Onur 
Published: November 2021

Aim: Infections of sterile body fluids (SBFs) require rapid and accurate diagnosis and treatment, since their morbidities and mortalities are high. To achieve this goal, definite epidemiologic data is absolutely required, since empiric and preemptive treatments are mainly based on this. The aim of this study was to evaluate infectious agents isolated from SBFs, susceptibility results and molecular analysis (PCR) data, retrospectively.
Material and Method: Clinical samples of SBFs (Cerebrospinal, pleural, peritoneal, pericardial and synovial fluids) obtained from January 2017 to December 2020 in Atatürk City Hospital (tertiary center) were included. Identification of bacterial and fungal agents and antibiotic susceptibility were done by conventional and automated system (BD Phoenix™, Becton Dickinson Co., Sparks, MD, USA). Löwenstein-Jensen media and BACTEC Mycobacteria Growth Indicator Tube 960 (Becton Dickinson Co., Sparks, MD, USA) were used for mycobacterial analysis. Bosphore Viral Meningitis Panel Multiplex PCR Kit (Anatolia Geneworks, İstanbul, Turkey) were applied to detect HSV-1, HSV-2, VZV, Enterovirus and/or Parechovirus.
Results: A total of 221 (9.74%) organisms were detected among 2269 samples. Particularly common gram negative bacterial agents covered the top of the list (Escherichia coli, Pseudomonas spp., Klebsiella spp. and Acinetobacter baumannii-Acinetobacter calcoaceticus complex). Staphylococcus aureus was the most frequent gram positive strain, followed by enteroccocci. Most of the A. baumannii isolates were multidrug resistant, Pseudomonas spp. showed over than 20% resistance rate to ceftazidime, cefepime and piperacillin-tazobactam. All enterococci were vancomycin-susceptible, one S. aureus strain was methicillin-resistant. All Mycobacterium tuberculosis complex isolates were found to be susceptible to first-line anti-tuberculosis drugs.
Conclusions: Continuous laboratory surveillance even in local phase is important to guide clinicians. Even though our data did not show significant changes, improvements on laboratory capabilities and clinical awareness must be done. Isolation rates might be underestimated due to requirement of improvements in our laboratory, especially about sampling, anaerobe transportation and usage of blood culture vials.
The spectrum of underlying diseases in children with autoimmune hemolytic anemia
Authors: ÖZCAN Alper , CANSEVER Murat , YILMAZ Ebru , ÜNAL Ekrem , KARAKÜKÇÜ Musa , PATIROĞLU Türkan 
Published: November 2021

Aim: Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against red blood cells. We aimed to describe the clinical presentation, hematologic and biochemical profiles, treatment modalities, underlying diseases and outcomes in children suffering from AIHA.
Material and Method: In a retrospectively manner, we consecutively recrutied 62 children (aged 1 month-18 years) with AIHA who had been followed in Erciyes University Child Hospital between January, 2000 and November, 2017.
Results: The mean age at time of diagnosis was 61.9±51.9 months (range:1-192) in 62 children including 28 girls and 34 boys. The most common complaints included fatigue and fever while the most common findings were jaundice and hepatosplenomegaly. In 22 children (35.4%), there was a comorbid, active, non-specific infection (upper respiratory tract infection, lower respiratory tract infection, diarrhea, urinary tract infection). At time of diagnosis, mean hemoglobin (Hb) level was 6.9±2.5 g/dL (range: 5-9). The glucocorticoid therapy was given in majority of the patients while no medical treatment was given to 4 patients. Of the patients with primary AIHA, 6 patients were unresponsive to the treatment while one patient responded partially. It was found that there were underlying risk factors in 36 patients with secondary AIHA, as immunodeficiency and autoimmune disorders being the most common risk factors.
Conclusion: The immunodeficiencies were highly prevalent in children included. By advance of whole exome sequencing technology, we believe that primary immunodeficiencies was the most common underlying disease in our study detected quite high in presented children.
Transplantation for ultra high-risk neuroblastoma patients: effect of tandem autologous stem cell transplantation
Authors: YILMAZ Ebru , SAMUR Muhammed Bahadır , ÖZCAN Alper , ÜNAL Ekrem , KARAKÜKÇÜ Musa 
Published: November 2021

Aim: Neuroblastoma is a tumor with a high mortality rate originating from primitive sympathetic ganglion cells. In recent years, the definition of "ultra high-risk" has been used, in which the response to treatment is added in addition to the disease characteristics. In this study, the results of tandem high-dose Iodine 131 (131I) metaiodobenzylguanidine (MIBG) and tandem autologous hematopoietic stem cell transplantation (HSCT) in patients who were diagnosed as refractory after first-line treatments and considered with ultra-high risk nöroblastom (NBL) in Erciyes University Medical Faculty Pediatric Bone Marrow Transplant Center were shared.
Material and Method: Eleven patients who underwent tandem MIBG and autologous HSCT with the diagnosis of refractory/ultra high-risk NBL between 2011 and 2021 were included in the study. Patient's data were obtained retrospectively using an electronic or manuscript medical record.
Results: Tandem autologous HSCT and MIBG treatment were applied to 11 patients with a median age of 40.5 months who were diagnosed with refractory/ultra high-risk neuroblastoma. In our study, the overall survival rate was 54.5% and event-free survival (EFS) was 39% at a median follow-up of 20.7 (7.8-105.6) months. Of the 6 surviving patients, 4 are followed in complete remission and 2 in partial remission.
Conclusion: Our study is the only study that includes a group of patients who received tandem high-dose MIBG and tandem autologous HSCT transplantation in refractory NBL patients without cytokine and immunotherapy. Tandem transplantation and MIBG therapy in ultra-high-risk NBL cases remain promising with acceptable toxicity. Adding immunotherapy to this treatment protocol and combining it with new treatment modalities such as anaplastic lymphoma kinase (ALK), which also takes into account genetic characteristics, may increase survival and event-free survival rates.
Anti-inflamatórios não esteroides e problemas renais
Authors: Santos Ellen Juliana da Silva , Silva Filho Severino Mariano da , Guedes João Paulo 
Published: November 2021

O processo inflamátorio é uma resposta do sistema imunológico a algum estímulo nocivo que pode ser causado por traumas físicos, químicos, microbiológicos ou até lesões a anticorpos, ou seja ele pode ser gerado por bactérias, vírus, fungos e por alguns fatores externos como calor ou trauma físico. Os AINEs são anti-inflamatórios não esteroides que possuem três funções:Anti-inflamatória,analgésica e anti-térmica,o mecanismo de ação desta classe consiste na inibição da cascata do ácido araquidônico ,substrato de duas vias: a via da Lipoxigenase (LOX) e a vida da Ciclooxigenase (COX). Quando o ácido araquidônico é convertido pela COX, ele produz as prostaglandinas e tromboxano, inibindo as ciclooxigenases I e II e assim,dando inicio aos sintomas recorrentes da inflamação .A cicoxigenase I possui função constitutiva e está presente na mucosa gástrica e renal, nos rins ela contribui com funçóes fisiológicas,com efeito vasoditador, atua no sistema nervoso e no sistema renina-angiotensina-aldosterona ,regulando o fluxo sanguíneo no órgão. Os AINEs inibem a enzima COX, podendo resultar em diversos danos renais agudos o crônicos, no uso crônico o risco aumenta em diversas nefrotoxicidades.
Estresse hídrico em plantas: uma revisão
Authors: Campos Anna Júlia de Moraes , Santos Sarah Medeiros , Nacarath Inaia Rhavene Freire Fagundes 
Published: November 2021

O estresse hídrico é uma problemática que limita a produção e desenvolvimento de vários vegetais, principalmente em períodos secos o qual o índice fluvial e menor. Esta revisão compila informações que nos permite compreender como ocorre o estresse por falta de água, um recurso de extrema importância para o desenvolvimento das plantas, sendo a água um componente extremamente determinante para a sobrevivência dos vegetais, sendo responsável por trocas gasosas, fotossíntese, transporte de nutrientes e outros. Desta forma, diante os dados obtidos nas plataformas de pesquisa Google acadêmico, Scielo, Embrapa e outros, discorremos sobre as respostas das plantas frutíferas, forrageiras e leguminosas submetidas ao estresse hídrico, destacando os efeitos causados em modo geral e citar algumas das peculiaridades que o estresse causa nessas plantas, além dos meios de adaptação que essas plantas adquirem para sobreviver durante períodos de seca e como a água é importante em vários estágios de desenvolvimento das plantas.
Pedagogo hospitalar: os desafios e a atuação em prol dos pacientes através da prática pedagógica
Authors: Balbino Samara da Silva , Rodrigues Millena Gonçalves , Dias Adriana Keila 
Published: November 2021

A importância da pedagogia hospitalar no atendimento de crianças e adolescentes hospitalizados, que devem ter o direito e acesso do ensino aprendizagem de forma lúdica para que não percam ao ano letivo. O trabalho do pedagogo neste ambiente deve estar vinculado com as praticas pedagógicas, pois é um processo que tende a ter necessidade de atenção e reflexão para que a educação seja mais flexível para as crianças e adolescentes que ali se encontra. Considerando as informações, objetivo do presente estudo é abordar os desafios do pedagogo no ambiente hospitalar e compreender os processos da pedagogia hospitalar no contexto das crianças/pacientes e a atuação dos pedagogos. Este documento foi construído através de buscas realizadas em plataformas de pesquisas como, o Google Acadêmico, repositórios de faculdades, entre outras paginas da internet. De forma geral, foi possível perceber que o trabalho realizado pelo pedagogo hospitalar é de suma importância, pois através deste trabalho crianças e adolescentes hospitalizados receberam de forma correta e lúdica os processos do ensino-aprendizagem onde apresentaram por meio deste trabalho um certo grau de desenvolvimento cognitivo, tendo a continuação dos seus estudos dentro do hospital com entusiasmo e uma boa autoestima.
A enfermagem e o empreendedorismo: uma revisão narrativa sobre os desafios do enfermeiro empreendedor
Authors: Braga Maria Nathaly de Oliveira Sousa , Sousa Haigle Reckziegel de , Viana Janayna Araújo , Leite Cristina Limeira , Fernandes Orquideia da Silva 
Published: November 2021

A enfermagem vem se tornando um setor cada vez mais propício ao empreendedorismo, com a extensão do serviço do profissional da enfermagem para além dos muros do ambiente hospitalar. Empreender vem sendo uma forma de conseguir um novo nicho econômico promissor para esse profissional. Este trabalho objetiva revisar o conteúdo produzido sobre o empreender na enfermagem, assim como, auxiliar pesquisas futuras na área. Trata-se de uma revisão narrativa, com abordagem qualitativa, onde foram feitas buscas em diversos periódicos de saúde, nacionais e internacionais publicados no período entre 2011 e 2021. O resultado do trabalho mostra que a enfermagem é uma profissão dinâmica, que exige resiliência, criatividade e coragem do profissional enfermeiro. O empreender na enfermagem não é o futuro da profissão, é o presente. Felizmente a dinâmica da profissão já possibilita ao profissional de enfermagem inovar, e como visto até aqui, inovar é um dos principais elementos do empreender. O que se busca, é uma melhor e mais completa formação acadêmica sobre a arte do empreender ainda na faculdade. Compreender os riscos e benefícios dessa ação, antes de concluir a graduação, pode definir o perfil profissional dos egressos do curso.
У ПОШУКАХ СОЮЗНИКІВ: УКРАЇНСЬКА ТЕМАТИКА У ВІЙСЬКОВІЙ ПЕРІОДИЦІ ЛИТВИ 1920-1940 РОКІВ
Authors: Йокубаускас Вітаутас , Петрик Артем Миколайович 
Published: November 2021

Стаття присвячена проблематиці висвітлення української тематики на сторінках спеціалізованої військової періодики, що видавалася у міжвоєнній Литовській Республіці. Робота базується на використанні симбіозу принципів: застосування математичних методів задля проведення кількісного аналізу змісту досліджуваного матеріалу, а також задіяння традиційного якісного методу. Основними виданнями які являються об’єктами розгляду авторів, виступають видання: Trimitas, Karys, Kardas. Хронологічні межі дослідження охоплюють період 1920-1940 років. У статті відображено перебіг процесу комунікації між українським визвольним рухом та міжвоєнною Литовською державою, а також приділено окрему увагу причинам посилення та спаду інтересу до тематики України та українського визвольного руху у литовській військовій пресі у рамках цільової хронології.