bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internacionalización en el sector aéreo de América Latina: estudio multicaso de Aeroméxico, Avianca y Latam (Internationalization in the Latin American air sector: multi- case study of Aeromexico, Avianca and Latam)
Authors: Lopez Jose Satsumi , Montañez Cuevas Mauricio Alejandro , Zertuche Zertuche Jorge Antonio , Paez Aguirre Daniel Gregorio , Martinez Cespedes Alejandro 
Published: July 2021

Abstract. The objective of this paper is to analyze the internationalization strategies of the Latin American airlines: Aeromexico (Mexico), Avianca (Colombia) and LATAM (Chile). For this, a qualitative multi-case study technique was applied. The research question that is intended to answer in this paper is: in what way are the main airlines in Latin America internationalized? The results suggest that the airlines studied use similar internationalization strategies, which are based on strategic alliances with other airlines in order to offer a better service to their passengers. They were also identified as the main characteristics of these airlines that are strong in their domestic market (especially Aeromexico) and then they start to expand their operations abroad. Likewise, Avianca and LATAM have the main market in Latin America, while Aeromexico has a greater presence in the United States.Key words: Aeromexico, airline industry, Avianca, internationalization, LATAM, service sectorJEL: F23, M16.Resumen. El objetivo de este trabajo es analizar las estrategias de internacionalización de las aerolíneas latinoamericanas Aeroméxico (México), Avianca (Colombia) y LATAM (Chile). Para esto se aplicó una técnica cualitativa de estudio multi-caso. La pregunta de investigación que se pretende responder en este trabajo es ¿de qué manera se internacionalizan las principales aerolíneas en América Latina?. Los resultados sugieren que las aerolíneas estudiadas utilizan estrategias similares de internacionalización, las cuáles están basadas en alianzas estratégicas con otras aerolíneas para poder ofrecer un mejor servicio a sus pasajeros. Además fueron identificadas como principales características de estas aerolíneas que son fuertes en su mercado interno (sobre todo Aeroméxico) y de ahí parten para poder expandir sus operaciones hacía el exterior. Asimismo Avianca y LATAM tiene como principal mercado América Latina, en cambio Aeroméxico tiene una mayor presencia en Estados Unidos.Palabras clave: Aeroméxico, Avianca, internacionalización, LATAM, sector aéreo, sector servicios
Factores clave de rendimiento para optimizar costos en proyectos de empresas manufactureras en Tecate, B.C. México: Una identificación mediante Análisis Factorial y Rho de Spearman
Authors: Reyes Mendoza M.A. Angelica , Rositas Martínez Dr. Juan , Cortés Alejandro Dr. Klender Aimer , Tamez Garza Dr. Silverio 
Published: July 2021

El propósito de esta investigación fue determinar los factores mediante los indicadores clave de rendimiento, conocido por sus siglas en inglés Key Performance Indicators (KPI) y su impacto en la optimización de costos en proyectos. Se muestra un enfoque cuantitativo, descriptivo-correlacional, con diseño no experimental, de corte transversal, la unidad de análisis fue; empresas medianas manufactureras de Tecate, Baja California, México, se realizaron 31 encuestas a gerentes de proyectos. Las variables fueron; factores clave de rendimiento (independiente) y optimización de costos (dependiente). A través del análisis factorial, fue posible determinar 11 indicadores que explicaron el 81.741% de los 26, agrupándolos en 4 factores: F1.Factor de Desempeño del Proceso, F2.Factor de Riesgos y Problemas, F3.Factor Organizacional y F4.Factor Ambiental. Posteriormente mediante el análisis de correlación de Rho Spearman, se encontró una correlación significativa positiva media del F3.Factor Organizacional con las cuatro dimensiones de la variable independiente. El F2.Factor de Riesgos y Problemas, con la dimensión Y3.Determinar el Presupuesto y con Y4.Control de Costos. El F4.Factor Ambiental con la dimensión Y3.Determinar el Presupuesto de 0.573** y en Y1.Estimación de Costo de 0.427*. Solo el F1. Factor de Desempeño del Proceso, no tuvo ninguna correlación significativa con la variable dependiente. En consecuencia, se rechazó la hipótesis nula donde se dijo que la optimización de costos en los proyectos no depende de los factores clave de rendimiento y se aceptó la hipótesis de investigación en la cual se planteó que los factores clave de rendimiento tiene un impacto positivo en la optimización de costos.
Analysis Method of Lactoferrin Based on Uncoated Capillary Electrophoresis
Authors: Chen Hui , Wang Zhenyu , Fan Fengjiao , Shi Pujie , Xu Xianbing , Du Ming , Wang Cong 
Published: July 2021

The analysis of lactoferrin separation will be an important application in prospect. To develop a new strategy for the detection of lactoferrin, this work adopted the method of uncoated Capillary Electrophoresis (CE), through optimizing the parameters of background electrolyte, pH, surfactant, buffers of the system solution. The optimum lactoferrin separation by CE is 50 mM phosphates buffer added 6M urea. In positive voltage, lactoferrin was separated by CE at pH 4.0. In reverse voltage, lactoferrin can also be separated at pH 10.0 with 50 mM ammonium ace. The auxiliary air pressure was got involved to decrease the absorption by silica capillary through a range of gradient intensity of air pressure. By comparison with 1.2, 1.5 and 1.8 psi, the pressure of 0.5 psi can significantly alleviate the absorption. The best detection conditions of lactoferrin were obtained, which are pH 4.0, 50 mM phosphates with 6M urea, 0.5 psi auxiliary air pressure with the limit of quantification at 0.04 mg/mL and the limit of detection at 0.01 mg/mL. Finally, lactoferrin can be quantitatively detected well and effectively, which the standard curve is y = 117807x + 3018.61374.
KEBIJAKSANAAN APBD DAN KESEJAHTERAAN MASYARAKAT DI PROVINSI SULAWESI SELATAN
Authors: Kusreni Sri 
Published: July 2021

Study on the policy of APBD and its implication toward the welfare of people in South Sulawesi is aimed at analyzing and searching the influence of local fiscal capacity, capital expenditure and budgeting toward the welfare of the people. Data of this study is quantitatively analyzed by regression. The result points up that: (1) local fiscal capacity and allocation of capital expenditure have positive correlation and significant influence toward the welfare of the people; (2) budgeting has negative correlation and insignificant influence toward the welfare of the people; (3) 23.1 percent of the welfare of the people is significantly influenced by the variables of the policy of APBD, while the rest is influenced by other variables outside the model; and (4) fiscal capacity has larger influence toward the welfare of the people than local capital expenditure.Â Keywords: Â Â Â Â Â fiscal capacity, local government expenditure, budgeting and welfare.
FAKTOR PENANGULANGAN TERJADINYA WASTE PADA PROYEK KONSTRUKSI DI SURABAYA
Authors: Beatrix Michella , Rochmah Nurul , Sarya Gede , Dwijayanto Pebru 
Published: July 2021

AbstractLarge and small scale construction projects have waste that cannot be predicted in advance, even the amount cannot be predicted directly, whether it is in large or small amounts. The existence of waste can have a significant impact that can affect construction costs. Waste can have both negative and positive impacts. Good waste management will have a positive impact on the company in terms of cost, even time, and quality, but if the waste that occurs cannot be handled or managed properly it will harm the company in terms of cost, time, and even in terms of quality. In this case, the party that always gets the impact of the waste is the contractor.This study focuses on mitigating the occurrence of waste that is how to minimize it. Thisstudy uses the distribution of questionnaires to the contractor in Surabaya. The results of this study are 5 item indicators on how to minimize the highest ranking. The 5 items are Updating material requirements, Mixing, transporting, and placing concrete at the right time, Increasing the competence and expertise of labor, Provision of good and adequate material/warehouse storage facilities, and accurate material measurement. Abstrak Proyek konstruksi dalam skala besar maupun kecil, memiliki waste yang tidak dapat diprediksi sebelumnya, bahkan jumlahnya pun tidak dapat diprediksi secara langsung, apakah itu dalam jumlah besar ataupun jumlah yang kecil. Adanya waste dapat memberikan dampak yang signifikan yang dapat mempengaruhi biaya konstruksi. Pada dasarnya waste dapat memberikan dampak negatif maupun positif. Pengelolaan waste yang baik akan memberikan dampak positif bagi perusahaan dalam segi biaya, bahkan waktu dan mutu, namun apabila waste yang terjadi tidak dapat diatasi atau dikelola dengan baik maka akan memberikan dampak negatif bagi perusahaan dalam segi biaya, waktu bahkan dalam hal mutu. Dalam hal ini pihak yang selalu mendapatkan dampak dari adanya waste adalah pihak kontraktorPenelitian ini memfokuskan pada faktor penanggulangan terjadinya waste yaitu cara meminimalisirnya. Penelitian ini menggunakan penyebaran kuisioner kepada pihak kontraktor di Surabaya. Hasil dari penelitian ini adalah 5 item indicator cara meminimalisir yang memiliki ranking tertinggi. 5 item tersebut adalah Updating kebutuhan material, Mencampur, mengangkut dan menempatkan beton pada waktu yang tepat, Meningkatkan kompetensi dan keahlian tenaga kerja, Penyediaan fasilitas penyimpanan material/gudang yang baik dan memadai, dan Pengukuran bahan yang akurat.
EVALUASI LEVEL KINERJA GEDUNG 6 LANTAI DENGAN METODE NON-LINEAR TIME HISTORY ANALYSIS
Authors: Rochmah Nurul , Beatrix Michella , Sutriono Bantot 
Published: July 2021

AbstractIndonesia is a ring of fire area where earthquakes frequently occur. By realizing this, buildings in Indonesia need to calculate earthquake loads based on SNI 03-1726-2019 to minimize victims due to building collapse when earthquakes occur.It is also necessary to evaluate the performance level of a building, in this case a 6-storey building located in the Malang area. For determining the level of performance, a method called Non-Linear Time History Analysis is used. In this calculation used San Fernando, Kobe and Landers ground motion.Based on the results from the evaluation using the Non-Linear Time History method got the maximum drift story 0.137 m that occurs in Kobe ground motion. So that the maximum total drift Dt / H is 0.137 / 21.95 = 0.0063 <0.01. Based on these results, the building performance level includes IO (Immediate Occupancy). AbstrakIndonesia termasuk daerah ring of fire dimana suatu daerah yang sering terjadi gempa. Dengan menyadari hal tersebut, bangunan-bangunan yang ada di Indonesia perlu memperhitungkan beban gempa yang ada berdasarkan SNI 03-1726-2019 untuk meminimalisir korban akibat keruntuhan bangungan yang terjadi akibat gempa. Karena itu perlu juga untuk mengevaluasi level kinerja suatu gedung dalam hal ini gedung 6 lantai yang terletak di daerah Malang. Pada gedung ini untuk dapat diketahui level kinerjanya, maka, digunakan metode yang bernama Non-Linear Time History Analisis. Ground motion yang dipakai adalah San Fernando, Kobe dan LandersBerdasarkan hasil yang diperoleh dari evaluasi dengan metode Non-Linear Time History Analisis ini adalah maximum drift story terbesar adalah 0,137 m yang terjadi pada ground motion Kobe. Sehingga Maximum total driftnya Dt/H adalah 0,137/21,95 =0,0063<0,01. Berdasar hasil tersebut lever kinerja gedung termasuk IO (Immediate Occupancy).
Histomorphological Mimickers of benign prostatic lesions with prostatic adenocarcinoma
Authors: Murgod Priyanka Sangappa , Doshi Preeti Rajeev , Nisal Amit Ravindra , Nimbargi Ravindra Chandrashekar 
Published: July 2021

Background: The prostate is a walnut-sized organ that surrounds the urethra. More than 99% of prostate cancers are prostatic adenocarcinoma. It is the second most commonly occurring cancer in men and the fourth most commonly occurring cancer in India and all over the world. Numerous lesion of the prostate are very similar to prostate cancer, hence awareness is very important. This study aimed to determine the histopathological features of prostate adenocarcinoma and its common mimickers.Materials and Methods: A retrospective study of histopathological features of radical prostatectomy and transurethral resection of the prostate specimens, sent to the department of pathology for a period of one year. A brief clinical history and serum prostate-specific antigen levels were noted.Results: The surgical specimens of 303 cases of prostatic diseases were studied. Benign prostatic hyperplasia was the most frequent diagnosis in 192 patients followed by Prostate adenocarcinoma seen in 80 patients. Prostatic intraepithelial neoplasia formed the predominant mimicker (5.9%), followed by basal cell hyperplasia (3.0%). Serum prostate-specific antigen was seen in the range of 1.73 - 100 ng/ml in the cases of adenocarcinoma. In the mimics, prostate-specific antigen was in the range of 1.2- 18ng/ml.Conclusions: Biopsy remains a gold standard for the diagnosis of adenocarcinoma and its mimickers. The lesions in this study were diagnosed on hematoxylin and eosin staining.
Study of histomorphological spectrum of eyelid lesions
Authors: Shrestha Reshmi , Sayami Gita 
Published: July 2021

Background: Eyelid pathologies are the most common surgical specimens encountered among all of the ophthalmic lesions and constitute a wide range of diseases by their unique histologic features. This study aims to find out the histopathological spectrum of eyelid lesions, their demographic distribution, and preferential location prevalent in our community.Materials and Methods: This is an observational study in which we retrospectively evaluated the data of 692 patients retrieved from the histopathology department of National Reference Laboratory, Kathmandu, from May 2016 to April 2019.Results: A total of 701 histologic diagnoses comprised of benign, precursor, and malignant lesions and accounted for 86.6%, 2.6%, and 10.8% respectively with preponderance in females. The common benign lesions included melanocytic nevus (17.7%), epidermal cyst (11%), hemangioma (8.9%), dermoid cyst (8.2%), chalazion (6.7%), and squamous papilloma (6.4%). Tumour of epidermal origin was the most common neoplastic lesion accounting for 31.2%. Basal cell carcinoma (50%) followed by sebaceous carcinoma (27.6%) and squamous cell carcinoma (14.5%) constituted the majority of malignant lesions prevalent above the age of 60 years with the preferential site of the upper eyelid for basal cell carcinoma and squamous cell carcinoma; and lower eyelid for sebaceous carcinoma.Conclusions: Benign eyelid lesions are more prevalent than malignant ones with overall female preponderance. Epidermal tumours are common among neoplasms. A malignant tumour, a disease of an elderly individual, is predominated by basal cell carcinoma followed by sebaceous carcinoma, an aggressive tumour with a high recurrence rate in our population.
Liudmyla Bruievych’s water-colors in the 1990s
Authors: Lamonova O. 
Published: July 2021

The aim of this study is to analyze in detail the watercolors by Liudmyla Bruievych, made in the 1990s: “Tuha” (1992), “Raiuvannia” (1993), “Trapeza” (1995), “Myslyvets” (1998) and others.
Methodology. The study of the works of the new generation of Ukrainian artists, which was completely formed after 1991, is just beginning. In particular, it refers to Liudmyla Bruievych, one of the most famous contemporary domestic graphic artists. The vast majority of publications about her works are popular and belong more to the genre of essay or interview (Bychkova (2000), Ivanochka (2012), Taran (1998, 2000, 2001, 2002, 2002), Shapiro (2012)) or are reviews for personal exhibitions of the artist (Lamonova (2004, 2004), Ostrovskyi (2002)). Among them there are extremely interesting texts of high literary quality (Tytarenko (2004), Borysova (1998), Panasiuk (1998, 1999)), but it is hardly possible to call them scientific researches.
Results. Liudmyla Bruievych is one of the most famous contemporary domestic graphic artists. The most popular of her works are etchings, for which the author uses watercolor of four colors (cerise paint, emerald green, ocher and gold): “Nich” (1991), series “Spokii” (“Koty”, “Rusalka”, “Try ryby”, “Ryba”, “Vaza”, all — 1994),” “Tanok vuzhiv abo Neskinchennist”, “Doistorychna tvaryna abo Drakon” (both — 1997). But during the 1990s, Liudmyla Bruievych actively worked not only on etchings, but also on watercolors. Among them there are works based on the unexpected use of folklore sources (“Tuha” (1992), “Rusalochka”, “Koroleva-rusalka”), biblical images (“Trapeza”, “Hallelujah” (all — 1995)), techniques of naive art (“Myslyvets” (1998)). The artist also created watercolor miniatures.
Novelty. This article is in fact the first scientific publication about the works of an interesting modern domestic graphic artist.
The practical significance. The research is a part of the individual planned theme of the author “Peculiarities of national tradition interpretation in the Ukrainian graphics of the 90s of the XX century. — 10s of the XXI century” and the general planned theme of Fine and Decorative Applied Arts department of the Institute of Art History, Folklore and Ethnology of M. T. Rylsky Institute of Art Studies, Folklore and Ethnology of the NAS of Ukraine “Ukrainian art from the Middle Ages to modern times: the search and formation of national identity in the context of world cultural space”.
Conclusions. Watercolors are an organic and integral part of the artist’s graphics. Plastic images found in watercolors could later be used in etchings.
A Proposal to Make Biomedical Research into Alzheimer’s Disease More Democratic Following an International Survey with Researchers
Authors: Daly Timothy , Houot Marion , Barberousse Anouk , Petit Amélie , Epelbaum Stéphane 
Published: July 2021

Background: Therapeutic research into Alzheimer’s disease (AD) has been dominated by the amyloid cascade hypothesis (ACH) since the 1990s. However, targeting amyloid in AD patients has not yet resulted in highly significant disease-modifying effects. Furthermore, other promising theories of AD etiology exist. Objective: We sought to directly investigate whether the ACH still dominates the opinions of researchers working on AD and explore the implications of this question for future directions of research. Methods: During 2019, we undertook an international survey promoted with the help of the Alzheimer’s Association with questions on theories and treatments of AD. Further efforts to promote a similar study in 2021 did not recruit a significant number of participants. Results: 173 researchers took part in the 2019 survey, 22% of which held “pro-ACH” opinions, tended to have more publications, were more likely to be male, and over 60. Thus, pro-ACH may now be a minority opinion in the field but is nevertheless the hypothesis on which the most clinical trials are based, suggestive of a representation bias. Popular vote of all 173 participants suggested that lifestyle treatments and anti-tau drugs were a source of more therapeutic optimism than anti-amyloid treatments. Conclusion: We propose a more democratic research structure which increases the likelihood that promising theories are published and funded fairly, promotes a broader scientific view of AD, and reduces the larger community’s dependence on a fragile economic model.
Bim Expression in Peritumoral Lymphocytes is Associated with Survival in Patients with Metastatic Clear Cell Renal Cell Carcinoma
Authors: Bhindi Bimal , Bearrick Elizabeth N. , Cheville John C. , Lohse Christine M. , Mason Ross J. , Shah Paras , Harrington Susan , Zhang Henan , Dong Haidong , Boorjian Stephen A. , Thompson R. Houston , Leibovich Bradley C. 
Published: July 2021

BACKGROUND: Bim (BCL-2-interacting mediator of cell death) is a downstream pro-apoptotic signaling molecule activated by the PD-1 pathway. OBJECTIVE: We sought to determine if Bim expression in peritumoral T-lymphocytes (PTLs) is associated with survival in patients with metastatic clear cell renal cell carcinoma (ccRCC). METHODS: Immunohistochemistry staining for Bim was performed on paraffin-embedded tumor tissue blocks from patients with metastatic ccRCC who underwent nephrectomy between 1990-2004. Associations of Bim expression with cancer-specific survival (CSS) and overall survival (OS) from date of metastasis were evaluated using multivariable Cox regression models, adjusting for age, sex, and metastases-score. RESULTS: 525 patients with metastatic ccRCC, of whom 169 (32%) had metastases at time of nephrectomy were studied. After multivariable adjustment, high Bim expression remained associated with worse CSS (HR = 1.31; 95% CI 1.07–1.59; p = 0.008) and OS (HR = 1.28; 95% CI 1.06–1.55; p = 0.01). The interaction between Bim and PD-L1 was not statistically significant for CSS ( p = 0.68) or OS ( p = 0.57), suggesting that the associations between Bim and survival outcomes were not significantly different based on tumor PD-L1 expression. CONCLUSION: High Bim expression in PTLs at nephrectomy is prognostic of worse CSS and OS in patients with metastatic ccRCC, irrespective of tumor PD-L1 expression. The role of earlier PD-1/PD-L1-directed therapy warrants evaluation in these patients.
PELATIHAN DAN PENDAMPINGAN DALAM PEMASARAN PRODUK SIRUP MARKISA MELALUI INTERNET MARKETING
Authors: Ngibad Khoirul , Sembilu Nambi , Ula Khotmil 
Published: July 2021

Di era revolusi industri 4.0 ini, penerapan internet marketing untuk meningkatkan penjualan harus dilakukan oleh para pelaku UMKM (Usaha Mikro Kecil Menengah). Pemasaran secara internet dapat dilakukan menggunakan perangkat elektronik/internet dan media pemasaran online, seperti: website/blog, media sosial (instagram, whatsapp, telegram, line, twitter, dan facebook) dan youtube. Di Desa Jatikalang terdapat UMKM yang bergerak dalam pembuatan sirup markisa. Dalam program PKM (Program Kemitraan Masyarakat), yang kami pilih adalah 1 mitra usaha yang bergerak dalam pembuatan sirup markisa. Berdasarkan hasil observasi, mitra ini belum mengetahui cara pemasaran menggunakan internet marketing untuk pemasaran produk secara online ke seluruh wilayah di Indonesia. Oleh karena itu, tim pengabdian masyarakat akan memberikan pelatihan dalam pemasaran produk sirup markisa melalui internet marketing, yang meliputi: website, fanspage, youtube dan instagram. Kegiatan pelatihan ini dilaksanakan selama dua hari menggunakan beberapa metode, meliputi: penyampaian informasi tentang pentingnya penerapan internet marketing dalam aspek pemasaran dan pelatihan penggunaan website, fanspage, instagram dan youtube untuk pemasaran produk sirup markisa secara online. Pelatihan internet marketing dengan mitra UMKM yang bergerak dalam pembuatan sirup markisa dapat diselenggarakan dengan lancar dan dapat memberikan pengetahuan dan keterampilan kepada mitra dalam penerapan internet marketing (pemasaran secara internet) untuk meningkatkan omset dan income.