bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Altered Functional Connectivity With Pain Features Integration and Interaction in Migraine Without Aura
Authors: Tian Zilei , Yin Tao , Xiao Qingqing , Dong Xiaohui , Yang Yunhong , Wang Menglin , Ha Guodong , Chen Jiyao , Liang Fanrong , Zeng Fang , Lan Lei 
Published: March 2021

IntroductionMigraine without aura (MwoA) is a primary type of migraine, a common disabling disorder, and a disabling neurological condition. The headache is a complex experience, a common form of pain, in which multiple sensory information dimensions are combined to provide a unified conscious event. Migraine ictal have unique neuroimage biomarkers, but the brain is also affected during the inter-ictal phase. According to the current studies, a hypothesis was constructed that the altered integration of pain spatial and intensity information impacts headache intensity in the inter-ictal period.MethodsIn this study, we applied theory-based region-to-region functional connectivity (FC) analyses to compare the differences in resting-state FC between MwoA participants and healthy controls with the pain integration hypothesis. After the correlation matrices between FC edges and clinical symptoms were constructed, the moderating effect and simple slope tests were investigated to explain whether and how the dysfunction of pain features discrimination affects the clinical symptoms.ResultsFunctional connectivity analyses showed significantly decreased FC edges between the left dorsolateral superior frontal gyrus (SFGdor) and left insula, and an increased FC edge between the left SFGdor and bilateral angular gyrus. The correlation matrix showed no significant correlation between significantly altered FC edge and headache duration, frequency, Zung self-rating anxiety scale, and Zung self-rating depression scale. Only one significantly altered edge in the MwoA condition was significantly correlated with headache intensity. Moderating Module 1 and 2 manifested the moderator variable (altered rs-FC edge) moderated the link between the normal edges and headache intensity.ConclusionThe pain features integration processes in migraineurs vary from HCs, related to the clinical symptoms during a migraine attack. Moreover, the clinical symptoms will be affected by one or more discrimination modules. And the spatial or intensity discrimination modules have a higher impact when combined with another module on clinical symptoms than the single module.
Baseline Serum C-Reactive Protein and Plasma Fibrinogen-Based Score in the Prediction of Survival in Glioblastoma
Authors: Wach Johannes , Apallas Stefanos , Schneider Matthias , Güresir Agi , Schuss Patrick , Herrlinger Ulrich , Vatter Hartmut , Güresir Erdem 
Published: March 2021

Objective: The present study investigates a score based on baseline C-reactive protein (CRP) and fibrinogen values (FC score) in 173 consecutive glioblastoma (GBM) patients.Methods: The optimal cut-off value for fibrinogen and CRP was defined as 3.5 g/dl and 3.0 mg/L, respectively, according to previous reports. Patients with elevated CRP and fibrinogen were classified with a score of 2, those with an elevation of only one of these parameters were allocated a score of 1, and those without any abnormalities were assigned a score of 0.Results: No significant differences in age, gender, tumor area, molecular pathology, physical status, or extent of resection were identified among the three groups defined by this score. Univariate survival analysis demonstrated that a high baseline FC score (≥1) is significantly associated with a shortened overall survival (OS) (HR: 1.52, 95% CI: 1.05–2.20, p = 0.027). A multivariate Cox regression analysis considering age (&gt;65/≤65), extent of resection (GTR/STR), MGMT promoter status (hypermethylated/non-hypermethylated), and FC score (0/≥1) confirmed that an elevated FC score (≥1) is an independent predictor of shortened OS (HR: 1.71, 95% CI: 1.16–2.51, p = 0.006).Conclusions: The baseline fibrinogen and CRP score thus serves as an independent predictor of OS in GBM. Further investigations of the role of inflammation in the prediction of a prognosis are needed.
Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity
Authors: Olorundare Olufunke Esan , Adeneye Adejuwon Adewale , Akinsola Akinyele Olubiyi , Ajayi Abayomi Mayowa , Agede Olalekan Ayodele , Soyemi Sunday Sokunle , Mgbehoma Alban Ikenna , Okoye Ikechukwu Innocent , Albrecht Ralph M. , Ntambi James Mukasa , Crooks Peter Anthony 
Published: March 2021

Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day valsartan, and their fixed-dose combinations in TZM-intoxicated Wistar rats that were randomly allotted into 10 groups of 6 rats for each group. Group I rats were treated with 10 ml/kg/day sterile water orally and 1 ml/kg/day sterile water intraperitoneally; Groups II, III, and IV rats were orally gavaged with 5 mg/kg/day valsartan and 1 ml/kg/day sterile water intraperitoneally, 0.25 mg/kg/day amlodipine and 1 ml/kg/day sterile water via the intraperitoneal route, 0.035 mg/kg/day lisinopril and 1 ml/kg/day sterile water administered intraperitoneally, respectively. Group V rats were orally treated with 10 ml/kg/day of sterile water prior to intraperitoneal administration of 2.25 mg/kg/day of TZM. Groups VI–VIII rats were equally pretreated with 5 mg/kg/day valsartan, 0.25 mg/kg/day amlodipine, and 0.035 mg/kg/day lisinopril before intraperitoneal 2.25 mg/kg/day TZM treatment, respectively; Groups IX and X rats were orally pretreated with the fixed-dose combinations of 0.25 mg/kg/day amlodipine +0.035 mg/kg/day lisinopril and 5 mg/kg/day valsartan +0.035 mg/kg/day lisinopril, respectively, before TZM treatment. Cardiac injury and tissue oxidative stress markers, complete lipids profile, histopathological, and immunohistochemical assays were the evaluating endpoints. Results showed that repeated TZM treatments caused profound increases in the serum TG and VLDL-c levels, serum cTnI and LDH levels, and cardiac tissue caspase-3 and -9 levels but decreased BCL-2 expression. TZM also profoundly attenuated CAT, SOD, GST and GPx activities, and increased MDA levels in the treated tissues. In addition, TZM cardiotoxicity was characterized by marked vascular and cardiomyocyte congestion and coronary artery microthrombi formation. However, the altered biochemical, histopathological, and immunohistochemical changes were reversed with amlodipine, lisinopril, valsartan, and fixed-dose combinations, although fixed-dose valsartan/lisinopril combination was further associated with hyperlipidemia and increased AI and CRI values and coronary artery cartilaginous metaplasia. Thus, the promising therapeutic potentials of amlodipine, lisinopril, valsartan and their fixed-dose combinations in the management of TZM cardiotoxicity, majorly mediated via antiapoptotic and oxidative stress inhibition mechanisms were unveiled through this study.
A Serious Game to Improve Emotion Regulation in Treatment-Seeking Individuals With Gambling Disorder: A Usability Study
Authors: Mena-Moreno Teresa , Fernández-Aranda Fernando , Granero Roser , Munguía Lucero , Steward Trevor , López-González Hibai , del Pino-Gutiérrez Amparo , Lozano-Madrid María , Gómez-Peña Mónica , Moragas Laura , Giroux Isabelle , Grall-Bronnec Marie , Sauvaget Anne , Mora-Maltas Bernat , Valenciano-Mendoza Eduardo , Menchón José M. , Jiménez-Murcia Susana 
Published: March 2021

Background: Serious games have shown positive results in increasing motivation, adherence to treatment and strengthening the therapeutic alliance in multiple psychiatric disorders. In particular, patients with impulse control disorders and other disorders in which the patient suffers from inhibitory control deficits (e.g., behavioral addictions) have been shown to benefit from serious games.Aim: The aim of this study was to describe the characteristics and to evaluate the usability of a new serious videogame, e-Estesia. This serious videogame was designed to improve emotion regulation in patients with gambling disorder (GD). Preliminary results from a pilot sample are also reported.Method: A pilot sample of 26 patients undergoing treatment for GD was recruited (ranging from 22 to 74 years, mean = 41.2 and SD = 12.9; 80.8% men). Participants used e-Estesia on a tablet, which was connected to a thoracic band that sent heart rate (HR) and heart rate variability (HRV) data to the videogame platform in order to provide biofeedback. The System Usability Scale was completed by patients to determine the usability of e-Estesia.Results and Discussion: e-Estesia performed comparatively well for all the explored groups (i.e., sex, age, and online vs. offline gambling: mean usability score = 83.8, SD = 13.1). Around 84.6% of the patients endorsed that it was easy to use. Female patients with GD presented higher HRV during the use of the serious videogame compared to men.
A Systematic Review Examining the Relationship Between Habit and Physical Activity Behavior in Longitudinal Studies
Authors: Feil Katharina , Allion Sarah , Weyland Susanne , Jekauc Darko 
Published: March 2021

Purpose: To explain physical activity behavior, social-cognitive theories were most commonly used in the past. Besides conscious processes, the approach of dual processes additionally incorporates non-conscious regulatory processes into physical activity behavior theories. Habits are one of various non-conscious variables that can influence behavior and thus play an important role in terms of behavior change. The aim of this review was to examine the relationship between habit strength and physical activity behavior in longitudinal studies.Methods: According to the PRISMA guidelines, a systematic search was conducted in three databases. Only peer-reviewed articles using a longitudinal study design were included. Both, habit and physical activity were measured at least once, and habit was related to physical activity behavior. Study quality was evaluated by assessment tools of the NHLBI.Results: Of 3.382 identified publications between 2016 and 2019, fifteen studies with different study designs were included. Most studies supported that positive correlations between habit and physical activity exist. Some positive direct and indirect effects of habit on physical activity were detected and only a minority of studies showed the influence of physical activity on habit strength. Studies differentiating between instigation and execution habit found positive correlations and revealed instigation habit as a stronger predictor of physical activity. The quality of studies was rated as reasonable using assessment tools of the NHLBI.Conclusion: This review revealed a bidirectional relationship between habit and physical activity. Whether habit predicts physical activity or vice versa is still unclear. The observation of habit influencing physical activity may be most appropriate in studies fostering physical activity maintenance while the influence of physical activity on habit may be reasonable in experimental studies with physical activity as intervention content to form a habit. Future investigations should differentiate between habit formation and physical activity maintenance studies depending on the research objective. Long-term study designs addressing the complexity of habitual behavior would be beneficial for establishing cue-behavior associations for the formation of habits. Furthermore, studies should differentiate between instigation and execution habit in order to investigate the influence of both variables on physical activity behavior independently.
Super Placebos: A Feasibility Study Combining Contextual Factors to Promote Placebo Effects
Authors: Olson Jay A. , Lifshitz Michael , Raz Amir , Veissière Samuel P. L. 
Published: March 2021

Background: Ample evidence demonstrates that placebo effects are modulated by contextual factors. Few interventions, however, attempt to combine a broad range of these factors. Here, we explore the therapeutic power of placebos by leveraging factors including social proof, positive suggestion, and social learning. This study aimed to test the feasibility of an elaborate “super placebo” intervention to reduce symptoms of various disorders in a pediatric population.Methods: In a single-arm qualitative study, participants entered an inactive MRI scanner which they were told could help their brain heal itself through the power of suggestion. The sample included 11 children (6–13 years old) diagnosed with disorders known to be receptive to placebos and suggestion (Attention Deficit Hyperactivity Disorder, Tourette Syndrome, chronic skin picking, and migraines). The children were given positive suggestions during 2–4 placebo machine sessions over the span of approximately 1 month. We assessed open-ended treatment outcomes via recorded interviews and home visits.Results: The procedure was feasible and no adverse events occurred. Ten of the 11 parents reported improvements in their children after the intervention, ranging from minor transient changes to long-term reductions in subjective and objective symptoms (e.g., migraines and skin lesions).Discussion: These preliminary findings demonstrate the feasibility and promise of combining a broad range of contextual factors in placebo studies. Future research is needed to assess the causal effects of such interventions.
DESCRIPCIÓN DEL INTENTO SUICIDA EN ARMENIA 2016-2018
Authors: Betancur-Pulgarin Carmen Luisa , Marín-Giraldo María del Pilar , Escobar-Angel Juliana , Marín-Rodríguez Diana Karina , Ortega-Muñoz Laura Isabella 
Published: March 2021

Introducción: La incidencia en Colombia del intento de suicidio ha ido en aumento año tras año, siendo el Quindío uno de los departamentos con una tasa de incidencia superior a la del país por lo que se hace necesario la caracterización de la población y la identificación de los factores relacionados con el intento de suicidio en la región.
Objetivo: Describir el intento de suicidio en la ciudad de Armenia durante el periodo 2016 – 2018.
Metodología: Se realizó un estudio observacional descriptivo con un primer intento suicida notificado por el SIVIGILA, se utilizó estadística descriptiva, pruebas de Chi cuadrado y Mann Whitney.
Resultados: Se analizó una muestra de 598 casos notificados de intento de suicidio donde más del 50% fueron menores de 29 años y según su estado civil el 68,9% se encontraba sin pareja; el estrato socioeconómico predomínate fue bajo, el mecanismo utilizado más frecuente fue la intoxicación. Se encontró relación entre intentos de suicidios previos y enfermedad crónica, problemas jurídicos, antecedente de trastorno psiquiátrico y consumo de SPA. Según el periodo epidemiológico en los años analizados la tendencia fue creciente para los periodos IX y XI.
A Study on the Economic Impact and Preventive Measures about Covid-19 in Tamilnadu
Authors: Sangamithra A , Dhavamani P 
Published: March 2021

This paper represents the COVID-19 Economic impact and pandemic that’s affecting our globe widely. The virus is sweeping across the world, parting a trail of efficient and group dent in its wake. Coronavirus has gone with new evils and miseries in the large-scale nation and health. The profitable force of the coronavirus is subsequently critical that the experts predicted that the forthcoming large scale depression would be as like as the 1929 terrible depression or at slightest will cross over the 2008 monetary crisis. Countries adopted a national scale lockdown as a head march to enclose the coronavirus. For that altogether, money-making behavior and everyday energy stopped, barren cities and the street feels like hollows. The macro monetary brunt of the coronavirus and the outlook of the macro cost-cutting measure after the epidemic ends. Corona infection is increasing rapidly in India and the number of people falling victim to the coronavirus infection. The coronavirus disease continues to increase across humankind next to a path that is tough to predict. The health, caring and socio-economic policies adopted by countries will control the rate and dilution of the recovery. The World Health Organization and health experts and doctors are advising people to be safe to raise awareness.
The Causes of Cancer: An Analysis of Avoidable Risk Factors
Authors: Sangamithra A 
Published: March 2021

Recently many new causes of cancer have been recognized, such as Sunlight, tobacco, pharmaceuticals, hormones, alcohol, parasites, fungi, bacteria, salted fish, wood dust, and certain herbs. However, they are additional causes of cancer that contains beta carotene, red meat, processed meats, low intake of fiber diets, poor Exclusive Breast Feeding (EBF), obesity, increased adult height, sedentary lifestyles, etc.; there is a knowledge imbalance in knowing the causes of cancer among the physicians as well as researchers. To prevent at and permit the early detection and effective treatment is necessary in this regard. Steps were taken to prevent, control and management of cancer are disturbed by the insufficient knowledge about the disease among the population. The ultimate aim of cancer management is to reduce the prevalence of cancer and to improve the quality of life. A practical way to identify cancer control risk is to understand the real risk factors for causing cancer. When the causes are not well explained and understood, it is difficult to treat the disease. Screening of asymptomatic populations and awareness of early signs and symptoms can certainly improve the treatment of cancer. Knowing the causes of cancer and knowledge about preventing it can cure the disease, prolong our life, and improve the quality of our life. Cancer research is crucial for effective planning and strategic Cancer Control Programmes (CCP).
An Economic Study on Financial Literacy among Working Women in Madurai City
Authors: Duraichamy J , Ponraj P 
Published: March 2021

Financial literacy is a knowledge related to financial instrument. In India women are equally earnable like men as and they financially independent. Financial literacy is an ability to manage and invest money on financial sources. Low financial literacy may cause financial loss in individual’s life which affect family as well. In this study financial literacy among working women has been analysed with the objective to find the financial literacy level among working women and to analyse the most preferred investment instrument. 45 samples were collected from working women over various field like textile industry, Information technology, fashion, teachers, professors and health industry based working women are taken as sample for the study. Data collected with the help of questionnaire, simple random sampling techniques is used for sampling, SPSS soft ware is used to analyse data.
Depression in modern phsycology: Study in the light of Islam
Authors: Khan Wajahat , Al-Rehman Dr. Khalil 
Published: March 2021

Immense sadness is called depression which is a common and serious mood disorder affecting 121 million people worldwide. It affects thoughts, feelings, behaviors, physical health and social life of a person. Depressed person overwhelms with sadness, loses interest in life and feels difficulty in making decisions. Brain chemistry, genetics, social and environmental factors may cause depression. Antidepressants and talking therapies are major treatment of depression. Islam is a true religion on the earth, which covers all aspects of life, bridges gap between spirit and matter, balances between individualism and collectivism. Fundamentals of Islam help in prevention and treatment of depression. A true Muslim believes in oneness of Allah almighty, he believes that Allah almighty alone runs all affairs of universe, considers life as a place of trials and tribulations, remains patient in difficulties of life, his heart is peaceful with the remembrance of Allah, he puts trust in Allah almighty, whenever he commits sin repents, seeks forgiveness from Allah almighty for his sin.
Contemporary Ideality of Sunnah al-Tarkiyah and unity of the Muslim Ummah: Research Study
Authors: Khalid Muhammad Usman , Hassan Dr. Muhammad Shahbaz 
Published: March 2021

This research eradicates the motives of innovation in the acts and deeds of Muslim Ummah. The un-islamic and unlawful additions are going to destruct the Ummah day by day. Innovation in its sense, has no more importance, but its pioneers are spreading it. All the disputes at last has roots in these innovations. Muslim ummah remained united until or unless innovations intermingled. As era went far off from the Nabwi era, the real sense of religion being vanished. As 14th century A.H. came nobody is there to prove innovations as no more part of Islam. Followers of innovation are increasing day by day and there are minority of Muslims left who want to get rid of it. Majority is serving his energy to prove that innovations are part of Islam. Secondly, they find its roots from Nabwi era which is useless. Thirdly, they wrongly proving its reward in this world and hereafter. Major objective of this research is to intimate all such acts and deeds which are wrongly now going to be the part and parcel of Shari’ah, as well as be the part of our legislation. Such kind of all deeds and actions must be condemned and discouraged for the sake of unity peace and sovereignty of the Muslim world.
The Concept of State intervention in economic Affairs: study of Islamic Injunctions
Authors: Ashraf Maria , Zahid Dr. Abdul Rouf 
Published: March 2021

Islam is a Religion in line with nature. It introduced its own economic system that up to the man’s needs and requirements. It contradicts the communism and capitalism and claims that Islamic economic structure guarantees the welfare of humanity. In this setup, the buyers and sellers are free to make their deals and every person has the equal opportunities to be a wealthy and prosperous trader. Muslims had implemented this system in their golden era and showed the benefits of this setup to world The basic question has been raised either state has authority to interfere the economic deals, why state is interested to involve or what would be the limits of their involvement. In this paper Descriptive Method and Comparative Study are used to study the concept of interference of state in economic matters. This research paper is an effort to understand the Islamic point of view that to what extent the Islamic State can interfere in economic policies, according to the Islamic injunction. In this article, it has been elaborated that the State has the legal and ethical right to intervene the economic matters when hoarding usury and gambling is rampant.