bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of psoriasis assessment system based on patch images
Authors: Moon Cho-I. , Lee Jiwon , Yoo HyunJong , Baek YooSang , Lee Onseok 
Published: September 2021

AbstractPsoriasis is a chronic inflammatory skin disease that occurs in various forms throughout the body and is associated with certain conditions such as heart disease, diabetes, and depression. The psoriasis area severity index (PASI) score, a tool used to evaluate the severity of psoriasis, is currently used in clinical trials and clinical research. The determination of severity is based on the subjective judgment of the clinician. Thus, the disease evaluation deviations are induced. Therefore, we propose optimal algorithms that can effectively segment the lesion area and classify the severity. In addition, a new dataset on psoriasis was built, including patch images of erythema and scaling. We performed psoriasis lesion segmentation and classified the disease severity. In addition, we evaluated the best-performing segmentation method and classifier and analyzed features that are highly related to the severity of psoriasis. In conclusion, we presented the optimal techniques for evaluating the severity of psoriasis. Our newly constructed dataset improved the generalization performance of psoriasis diagnosis and evaluation. It proposed an optimal system for specific evaluation indicators of the disease and a quantitative PASI scoring method. The proposed system can help to evaluate the severity of localized psoriasis more accurately.
Factors associated with inflamm-aging in institutionalized older people
Authors: de Oliveira Neto Leônidas , Tavares Vagner Deuel de O. , Agrícola Pedro Moraes Dutra , de Oliveira Larissa Praça , Sales Márcia Cristina , de Sena-Evangelista Karine Cavalcanti Maurício , Gomes Igor Conterato , Galvão-Coelho Nicole Leite , Pedrosa Lúcia Fátima Campos , Lima Kenio Costa 
Published: September 2021

AbstractThe increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.
Children do not distinguish efficient from inefficient actions during observation
Authors: Ossmy Ori , Han Danyang , Kaplan Brianna E. , Xu Melody , Bianco Catherine , Mukamel Roy , Adolph Karen E. 
Published: September 2021

AbstractObservation is a powerful way to learn efficient actions from others. However, the role of observers’ motor skill in assessing efficiency of others is unknown. Preschoolers are notoriously poor at performing multi-step actions like grasping the handle of a tool. Preschoolers (N = 22) and adults (N = 22) watched video-recorded actors perform efficient and inefficient tool use. Eye tracking showed that preschoolers and adults looked equally long at the videos, but adults looked longer than children at how actors grasped the tool. Deep learning analyses of participants’ eye gaze distinguished efficient from inefficient grasps for adults, but not for children. Moreover, only adults showed differential action-related pupil dilation and neural activity (suppressed oscillation power in the mu frequency) while observing efficient vs. inefficient grasps. Thus, children observe multi-step actions without “seeing” whether the initial step is efficient. Findings suggest that observer’s own motor efficiency determines whether they can perceive action efficiency in others.
Climate change and the increase of human population will threaten conservation of Asian cobras
Authors: Chowdhury Mohammad Abdul Wahed , Müller Johannes , Varela Sara 
Published: September 2021

AbstractAsian cobras (genus Naja) are venomous snakes distributed from the Middle East to Southeast Asia. Because cobras often live near humans settlements, they are responsible for a large part of snakebite incidents and as such pose a challenge for public health systems. In the light of growing human populations, correctly mapping the present and future ranges of Asian cobras is therefore important for both biological conservation and public health management. Here, we mapped the potential climatic niches of ten Asian cobra species for both the present and the future, with the aim to quantify changes in climate and human population densities relative to their current and future ranges. Our analyses reveal that cobras that are adapted to dry climates and inhabit islands have narrow climatic niches, while those of mainland species with larger geographic ranges are much wider. We also found a higher degree of fragmentation of future cobra distributions; within the next 50 years, Asian cobras will lose an average of around 60% of their current suitable climatic range. In the near future, Naja mandalayensis, N. sputatrix, N. samarensis, and N. philippinensis are likely to have no accessible suitable climate space left. Besides, a further increase of human populations in this region may also exponentially accelerate the effects of anthropogenic impacts. Solutions for conservation may involve awareness and appropriate use of law to overcome the rate of habitat degradation and the increase of animal trade of Asian cobras, while promoting investment on health systems to avoid snakebite fatalities.
Mean heart dose-based normal tissue complication probability model for pericardial effusion: a study in oesophageal cancer patients
Authors: Fukada Junichi , Fukata Kyohei , Koike Naoyoshi , Kota Ryuichi , Shigematsu Naoyuki 
Published: September 2021

AbstractWe investigated the normal tissue complication probability (NTCP) of the incidence of pericardial effusion (PCE) based on the mean heart dose (MHD) in patients with oesophageal cancer treated with definitive chemoradiotherapy. The incidences of PCE in any grade (A-PCE) and symptomatic PCE (S-PCE) were evaluated separately. To identify predictors for PCE, several clinical and dose-volume parameters were analysed using a receiver operating characteristic (ROC) curve and multivariate regression analysis. To validate its clinical applicability, the generated NTCP model was compared to the Lyman–Kutcher–Burman (LKB) model. Among 229 eligible patients, A-PCE and S-PCE were observed in 100 (43.7%) and 18 (7.9%) patients, respectively. MHD showed a preferable area under the curve (AUC) value for S-PCE (AUC = 0.821) and A-PCE (AUC = 0.734). MHD was the only significant predictor for A-PCE; MHD and hypertension were selected as significant factors for S-PCE. The estimated NTCP, using the MHD-based model, showed excellent correspondence to the LKB model in A-PCE and S-PCE. The NTCP curve of A-PCE was gentler than that of S-PCE and had no threshold. The MHD-based NTCP model was simple but comparable to the LKB model for both A-PCE and S-PCE. Therefore, the estimated NTCP may provide clinically useful parameters for predicting PCE.
A standardized extract of Asparagus officinalis stem improves HSP70-mediated redox balance and cell functions in bovine cumulus-granulosa cells
Authors: Ho Khoi Thieu , Homma Kohei , Takanari Jun , Bai Hanako , Kawahara Manabu , Nguyen Khang Thi Kim , Takahashi Masashi 
Published: September 2021

AbstractHeat shock (HS) protein 70 (HSP70), a well-known HS-induced protein, acts as an intracellular chaperone to protect cells against stress conditions. Although HS induces HSP70 expression to confer stress resistance to cells, HS causes cell toxicity by increasing reactive oxygen species (ROS) levels. Recently, a standardized extract of Asparagus officinalis stem (EAS), produced from the byproduct of asparagus, has been shown to induce HSP70 expression without HS and regulate cellular redox balance in pheochromocytoma cells. However, the effects of EAS on reproductive cell function remain unknown. Here, we investigated the effect of EAS on HSP70 induction and oxidative redox balance in cultured bovine cumulus-granulosa (CG) cells. EAS significantly increased HSP70 expression; however, no effect was observed on HSP27 and HSP90 under non-HS conditions. EAS decreased ROS generation and DNA damage and increased glutathione (GSH) synthesis under both non-HS and HS conditions. Moreover, EAS synergistically increased HSP70 and HSF1 expression and increased progesterone levels in CG cells. Treatment with an HSP70 inhibitor significantly decreased GSH level, increased ROS level, and decreased HSF1, Nrf2, and Keap1 expression in the presence of EAS. Furthermore, EAS significantly increased progesterone synthesis. Thus, EAS improves HSP70-mediated redox balance and cell function in bovine CG cells.
Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway
Authors: Ouyang Xin , Wang Zhengjia , Luo Mei , Wang Maozhou , Liu Xing , Chen Jiaxin , Feng JianGuo , Jia Jing , Wang Xiaobin 
Published: September 2021

AbstractTo investigate the effects of ketamine on glucose uptake and glucose transporter (GLUT) expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino]-2-Deoxyglucose (2-NBDG) was added to the cells to test the effects of ketamine on glucose uptake, production of lactate, and expression levels of GLUT, ERK1/2, AKT, and AMPK. Adult female C57BL/6 mice were subjected to chronic unpredictable mild stress (CUMS), 27 CUMS mice were randomly divided into the depression, ketamine (i.p.10 mg/kg), and FR180204 (ERK1/2 inhibitor, i.p.100 mg/kg) + ketamine group. Three mice randomly selected from each group were injected with 18F-FDG at 6 h after treatment. The brain tissue was collected at 6 h after treatment for p-ERK1/2 and GLUTs. Treatment with ketamine significantly increased glucose uptake, extracellular lactic-acid content, expression levels of GLUT3 and p-ERK in astrocytes and glucose uptake in the prefrontal cortex (P < 0.05), and the immobility time was significantly shortened in depressive-like mice (P < 0.01). An ERK1/2 inhibitor significantly inhibited ketamine-induced increases in the glucose uptake in depressive-like mice (P < 0.05), as well as prolonged the immobility time (P < 0.01). The expression levels of p-ERK1/2 and GLUT3 in depressive-like mice were significantly lower than those in normal control mice (P < 0.01). Ketamine treatment in depressive-like mice significantly increased the expression levels of p-ERK1/2 and GLUT3 in the prefrontal cortex (P < 0.01), whereas an ERK1/2 inhibitor significantly inhibited ketamine-induced increases (P < 0.01).Our present findings demonstrate that ketamine mitigated depressive-like behaviors in female mice by activating the ERK/GLUT3 signal pathway, which further increased glucose uptake in the prefrontal cortex.
Hydrogenation of pentenal over supported Pt nanoparticles: influence of Lewis-acid sites in the conversion pathway
Authors: Wei Xuejiao , Zhou Yajuan , Sun Xiaonan , Jiang Fuhua , Zhang Jintao , Wu Zeying , Wang Fei , Li Gao 
Published: September 2021

The superb TOF and high selectivity of Pt/CeAl are associated with the surface properties (e.g. medium Lewis acidic site). The unsaturated Ce4+/Al3+ cations pairs act as the acid sites and electron acceptors to polarize the CO bonds.
Full body virtual try‐on with semi‐self‐supervised learning
Authors: Lee Hyug‐Jae , Koo Byumhyuk , Ahn Ha‐Eun , Kang Minseok , Lee Rokkyu , Park Gunhan 
Published: September 2021

AbstractThis paper proposes a full body virtual try‐on which handles both top and bottom garments and generates realistic try‐on images. For the full body virtual try‐on, this paper addresses lack of suitable training data to align and fit top and bottom naturally. The proposed system consists of three modules: Clothing Guide Module (CGM), Geometric Matching Module (GMM), and Try‐On Module (TOM). CGM is introduced to generate a clothing guide map (CGMap) which describes the shape of a garment on a model. Unlike the single‐garment virtual try‐on scheme, it is impractical to collect meaningful data at a large scale for the multi‐garment system. To address this problem, two novel training strategies are proposed to leverage the existing training data. First, a pseudo triplet of model‐top‐bottom is generated from a pair of model‐top or model‐bottom which are already secured. Second, the CGM network is arranged to be exposed to both top and bottom garments during training. Then, the following GMM networks warp and align the top and bottom garments. Finally, TOM synthesizes a realistic try‐on image with the aligned garment and the CGMap. Experimental results prove remarkable performance of the proposed method in the full body virtual try‐on.
Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study
Authors: Stubert Johannes , Gründler Kathleen , Gerber Bernd , Richter Dagmar-Ulrike , Dieterich Max 
Published: September 2021

Abstract
Introduction Thrombospondin 1, desmoplakin and stratifin are putative biomarkers for the prediction of preterm birth. This study aimed to validate the predictive capability of these biomarkers in patients at risk of preterm birth.
Materials and Methods We included 109 women with symptoms of threatened spontaneous preterm birth between weeks 20 0/7 and 31 6/7 of gestation. Inclusion criteria were uterine contractions, cervical length of less than 25 mm, or a personal history of spontaneous preterm birth. Multiple gestations were also included. Samples of cervicovaginal fluid were taken before performing a digital examination and transvaginal ultrasound. Levels of cervicovaginal thrombospondin 1, desmoplakin and stratifin were quantified by enzyme-linked immunosorbent assays. The primary endpoint was spontaneous preterm birth before 34 + 0 weeks of gestation.
Results Sixteen women (14.7%) delivered before 34 + 0 weeks. Median levels of thrombospondin 1 were higher in samples where birth occurred before 34 weeks vs. ≥ 34 weeks of gestation (4904 vs. 469 pg/mL, p < 0.001). Receiver operator characteristics analysis resulted in an area under the curve of 0.86 (p < 0.0001). At an optimal cut-off value of 2163 pg/mL, sensitivity, specificity, positive predictive value and negative predictive value were 0.94, 0.77, 0.42 and 0.99, respectively, with an adjusted odds ratio of 32.9 (95% CI: 3.1 – 345, p = 0.004). Multiple gestation, cervical length, and preterm labor had no impact on the results. Survival analysis revealed a predictive period of more than eight weeks. Levels of desmoplakin and stratifin did not differ between groups.
Conclusion Thrombospondin 1 allowed long-term risk estimation of spontaneous preterm birth.
Hidden Reactivity of Barbituric and Meldrum’s Acids: Atom-Efficient Free-Radical C–O Coupling with N-Hydroxy Compounds
Authors: Terent’ev Alexander O. , Krylov Igor B. , Paveliev Stanislav A. , Budnikov Alexander S. , Segida Oleg O. , Merkulova Valentina M. , Vil’ Vera A. , Nikishin Gennady I. 
Published: September 2021

AbstractThe reactivity of CH-acidic and structurally related enol-containing heterocycles towards N-oxyl radicals is disclosed. Traditionally, these substrates have been considered as reactants for ionic transformations. Highly selective and efficient N-oxyl radical mediated C–O coupling of substituted barbituric or Meldrum’s acids with N-hydroxy compounds (N-hydroxyimides, hydroxamic acids, oximes, and N-hydroxybenzotriazole) was achieved using inexpensive manganese-containing salts as oxidants. Metal-free C–O coupling was demonstrated using diacetyliminoxyl as both the oxidant (hydrogen-atom acceptor) and the coupling partner.
An improved chain of spheres for exchange algorithm
Authors: Helmich-Paris Benjamin , de Souza Bernardo , Neese Frank , Izsák Róbert 
Published: September 2021

In the present work, we describe a more accurate and efficient variant of the chain-of-spheres algorithm (COSX) for exchange matrix computations. Higher accuracy for the numerical integration is obtained with new grids that were developed using global optimization techniques. With our new default grids, the average absolute energy errors are much lower than 0.1 kcal/mol, which is desirable to achieve “chemical accuracy.” Although the size of the new grids is increased by roughly a factor of 2.5, the excellent efficiency of the original COSX implementation is still further improved in most cases. The evaluation of the analytic electrostatic potential integrals was significantly accelerated by a new implementation of rolled-out versions of the Dupuis–Rys–King and Head-Gordon–Pople algorithms. Compared to our earlier implementation, a twofold speedup is obtained for the frequently used triple-ζ basis sets, while up to a 16-fold speedup is observed for quadruple-ζ basis sets. These large gains are a consequence of both the more efficient integral evaluation and the intermediate exchange matrix computation in a partially contracted basis when generally contracted shells occur. With our new RIJCOSX implementation, we facilitate accurate self-consistent field (SCF) binding energy calculations on a large supra-molecular complex composed of 320 atoms. The binding-energy errors with respect to the fully analytic results are well below 0.1 kcal/mol for the cc-pV(T/Q)Z basis sets and even smaller than for RIJ with fully analytic exchange. At the same time, our RIJCOSX SCF calculation even with the cc-pVQZ basis and the finest grid is 21 times faster than the fully analytic calculation.
Thermal strain analysis considering in-plane anisotropy for sputtered AlN on c- and a-plane sapphire under high-temperature annealing
Authors: Hayashi Yusuke , Uesugi Kenjiro , Shojiki Kanako , Tohei Tetsuya , Sakai Akira , Miyake Hideto 
Published: September 2021

High-temperature annealing of sputtered AlN (Sp-AlN) using a face-to-face configuration is a novel technique that has attracted considerable attention because it can reduce the threading dislocation density of Sp-AlN to 107 cm−2. However, drawbacks such as cracking, residual stress, and wafer curvature remain because of a high annealing temperature of 1700 °C. We previously developed a thermal strain analysis model that uses an elastic multilayer system to describe the elastic behavior of Sp-AlN on sapphire under high-temperature annealing. In this study, we expand this model to consider in-plane anisotropy. By performing thermal strain analysis of the curvature, strain, stress, and strain energy of c-plane AlN grown on c- and a-plane sapphire, our calculation successfully approximates the experimental results, even for an in-plane anisotropic structure. The proposed model is, therefore, useful for quantitative evaluation of the residual strain and can contribute to strain engineering of AlGaN-based deep-ultraviolet light-emitting diodes.
Perceptions about the design of informational materials used in the fight against COVID-19 in Portugal and
Brazil
Authors: Mont’Alvão Cláudia Renata , Duarte Emilia , Teles Julia 
Published: September 2021

Abstract
This study aimed to assess perceptions on the graphical informational materials designed to help in the fight
against COVID-19 in Portugal and Brazil. We assessed the perceptions using an online survey incorporating the AttrakDiff2TM
questionnaire. The results show that the perception of risk with relation to the COVID-19 pandemic is high among the respondents,
and that they believe that they will have mild symptoms if infected by the virus. The results also show that the materials
available in these countries were poorly designed and not effective in promoting adequate behaviour change. These findings can
contribute to future design projects whose aim is to design risk communication materials to inform and guide people facing health
crisis situations.
Ghost imaging based on pulsed radiation of terahertz spectrum range modulated by random phase screen
Authors: Leibov Lev S , Zalipaev Victor V , Ismagilov Azat O , Nasedkin Boris A , Petrov Nikolai V , Kalinichev Alexey A , Tcypkin Anton N 
Published: September 2021

Abstract
We present mathematical and computer modelling of ghost imaging technique based on broadband pulsed radiation of terahertz spectrum range, modulated by a random phase screen. The modelling is performed in both frequency and time domains. The quality of the reconstructed images is discussed and estimated.
THz and IR spectroscopy of endofullerene H2O@C60
Authors: Melentev Alexander , Zhukov Sergey , Balos Vasileios , Hoffman Gabriela , Alom Shamim , Belyanchikov Mikhail , Zhukova Elena , Dressel Martin , Bacanu George , Abramov Pavel , Levitt Malcolm , Whitby Richard , Gorshunov Boris , Sajadi Mohsen 
Published: September 2021

Abstract
Terahertz time-domain and infrared Fourier-transform spectroscopy techniques are used to investigate the properties of H2O@C60 endofullerene in 6 K – 300 K temperature interval. A number of absorption lines associated with rotational transitions of water molecule entrapped inside C60 cages are observed and assigned. Fitting the resonances with Lorenzian lineshapes allowed us to obtain temperature dependencies of absorption lines parameters – frequency, strength and damping.
Keylogger Detection and Prevention
Authors: Singh Arjun , Choudhary Pushpa , singh Akhilesh kumar , tyagi Dheerendra kumar 
Published: September 2021

Abstract
Keyloggers are kind of a rootkit malware that catch composed keystroke occasions of the console and save into log record, hence, it can capture delicate data, for example, usernames, PINs, and passwords, in this manner communicates into vindictive assailant without pulling in the consideration of clients. Keyloggers present a significant danger to deals and individual exercises such as E-business, internet banking, email talking, and framework information base. Antivirus programming that is ordinarily used to identify and eliminate known Keyloggers. Nonetheless, it can’t recognize obscure Keyloggers. This paper presents an outline of Keyloggers programs, types, qualities of Keyloggers and philosophy they use. At last we will break down the current discovery procedures, and investigate a few proactive methods.
Different Analysis of Rigid Pavement Subjected to Multi Axle Load and Temperature Effect
Authors: Parsania Vatsal , Solanki U J , Zala L B 
Published: September 2021

Abstract
In this study the axle load studies are carried out to determine actual load of each axles on the road surface. In the present study, Static Weighing method is used for the axle load survey. The Sample size of the axle load survey is determined by conducting Classified Volume Survey as per IRC: 58 – 2015. Axle load Spectrum is generated with the help of axle load study. Based on the Axle load survey and Warping stress, stress – deflection analysis is done with the help of Westergaard Theory, IRC-58 (2015) and ANSYS software. Results which are analysis by Ansys is closed to Westergaard theory and IRC – 58 (2015) In the present study, stretch Kankot to Vavdi, near Punitnagar, Rajkot is selected for the analysis study.