bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperthermia alters interleukin‐6 production in response to lipopolysaccharide via endoplasmic reticulum stress in bovine endometrial cells
Authors: Sakai Shunsuke , Inoue Yuki , Tanaka Keisuke , Yamamoto Yuki , Iwata Hisataka , Kimura Koji 
Published: October 2021

AbstractIn the postpartum period, cows experience the uterine bacterial infection and develop the endometritis. To eliminate bacteria and recover from endometritis, endometrial epithelial and stromal cells secrete the cytokine and chemokine, such as interleukin 6 (IL‐6), IL‐8, and monocyte chemotactic protein 1 (MCP1), to recruit immune cells. Moreover, the symptom of endometritis is prolonged in summer and we have recently indicated that hyperthermia suppresses and enhances the IL‐6 production in response to lipopolysaccharide (LPS) challenge in endometrial epithelial and stromal cells, respectively. However, the mechanisms for the opposite reaction of IL‐6 secretion in response to LPS challenge in both types of endometrial cells under hyperthermia conditions were still unclear. To reveal these mechanisms, both types of endometrial cells were cultured with LPS under the control (38.5°C) or hyperthermia (40.5°C) conditions and comprehensively analyzed differential gene expressions of them by RNA‐seq. In addition, based on these results, we examined the effect of endoplasmic reticulum (ER) stress on the IL‐6 production in both types of endometrial cells cultured with LPS under hyperthermia conditions. In comprehensive analysis, hyperthermia induced the ER stress in the endometrial stromal cells but not in the endometrial epithelial cells. Actually, we confirmed that hyperthermia increased the gene expression of BiP, ATF4, and sXBP1 and protein expression of BiP and phosphorylated inositol requiring 1, ER stress marker, in the endometrial stromal cells but not in the endometrial epithelial cells. Moreover, in the endometrial stromal cells exposed to LPS, activation and inhibition of ER stress enhanced the IL‐6 production under control conditions and suppressed it under hyperthermia conditions, respectively. In this study, we could uncover the one of causes for the disruption of IL‐6 production in response to LPS challenge in the endometrial cells under hyperthermia conditions. This finding might be a clue for the improvement of the symptom of endometritis in cows during summer.
Prognostic value of B lines detected with lung ultrasound in acute heart failure. A systematic review
Authors: Dubón‐Peralta Ester Emilia , Lorenzo‐Villalba Noel , García‐Klepzig José Luis , Andrès Emmanuel , Méndez‐Bailon Manuel 
Published: October 2021

AbstractPulmonary ultrasound is a simple diagnostic tool with immediate results for the assessment of pulmonary congestion in patients with heart failure (HF), allowing optimization of treatment by monitoring the dynamic changes identified. We aimed to evaluate the prognostic significance of the presence of B lines detected by lung ultrasound during hospitalization for heart failure. A search was conducted for scientific articles in PubMed, Embase, Google Scholar, and Cochrane databases including clinical trials, reviews, systematic reviews, and original articles that were related to the prognostic value of lung ultrasound in patients with HF in the last 5 years from 2016 to 2021. Studies including individuals aged ≥18 years evaluating the prognostic value of lung ultrasound in HF were included. Fourteen articles met inclusion criteria for analysis (three reviews, three systematic reviews with meta‐analysis, six prospective studies, and two retrospective studies). The presence of more than 30–40 B lines at admission were considered a risk factor for readmission or mortality as was persistent pulmonary congestion with the presence of ≥15 B‐lines. The presence of pulmonary congestion detected by lung ultrasound in acute heart failure has prognostic significance in terms of mortality and hospital readmission. Clinical trials are needed to evaluate whether diuretic therapy guided by lung ultrasound and the presence of B lines can reduce readmission and mortality in these patients.
Artemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo
Authors: Mancuso Rubia Isler , Azambuja Juliana Hofstätter , Niemann Fernanda Soares , Congrains Ada , Foglio Mary Ann , Rego Eduardo Magalhães , Olalla Saad Sara Teresinha 
Published: October 2021

AbstractLoss of endoplasmic reticulum (ER) homeostasis leads to ER stress, thus prolonged activation can lead to apoptosis. Herein, artesunate (ART) induced ER stress in leukaemia cells, resulting in eIF2α phosphorylation, activation of transcription factor 4, subsequent CHOP upregulation and XBP1 splicing. Furthermore, in vitro cyclin/CDKs reduction induced G1‐phase arrest. An in vivo xenograft model showed a consistent pattern of ART in reducing tumour burden, supporting roles in the UPR pathway, which we speculate could lead to apoptosis by NOXA activation. Moreover, ART were capable of increasing the survival of mice. Taken together, our data indicate that ART may represent an interesting weapon to fight leukaemia.
Adoptive transfer of GRP78-treated dendritic cells alleviates insulitis in NOD mice
Authors: Zhou Xiaoqi , Yang Muyang , Lv Yibing , Li Heli , Wu Sha , Min Jie , Shen Guanxin , He Yong , Lei Ping 
Published: October 2021

AbstractThe 78-kDa glucose-regulated protein (GRP78) has extracellular, anti-inflammatory properties that can aid resolving inflammation. It has been established previously that GRP78 induced myeloid CD11c+ cell differentiation into distinct tolerogenic cells. This tolerance induction makes GRP78 a potential therapeutic agent for transplanted allogeneic grafts and autoimmune diseases, such as type 1 diabetes. In this research, it is revealed that rmGRP78-treated NOD mice bone marrow-derived CD11c+ cells (GRP78-DCs) highly expressed B7-H4 but down-regulated CD86 and CD40, and retained a tolerogenic signature even after stimulation by LPS. In the assessment of in vivo therapeutic efficacy after the adoptive transfer of GRP78-DCs into NOD mice, fluorescent imaging analyses revealed that the transfer specifically homed in inflamed pancreases, promoting β-cell survival and alleviating insulitis in NOD mice. The adoptive transfer of GRP78-DCs also helped reduce Th1, Th17, and CTL, suppressing inflammatory cytokine production in vivo. The findings suggest that adoptive GRP78-DC transfer is critical to resolving inflammation in NOD mice and may have relevance in a clinical setting.
The climatology of extreme wildfires in Portugal, 1980–2018: Contributions to forecasting and preparedness
Authors: Carmo Miguel , Ferreira João , Mendes Manuel , Silva Álvaro , Silva Pedro , Alves Daniela , Reis Luís , Novo Ilda , Xavier Viegas Domingos 
Published: October 2021

AbstractAvailable research has extensively examined the spatiotemporal patterns of fire‐weather regime in Portugal, but a comprehensive climatology of extreme wildfires is still under development. This study calls for different strategies and scales of analysis aiming to describe the relationships between medium and low troposphere weather conditions and severe fire behaviour in mainland Portugal, between 1980 and 2018. In particular, critical fire‐weather patterns and thresholds that can contribute to operational and forecasting know‐how in short and medium time ranges are presented. We updated the general trends in the fire regime with a new, longer daily burned area series and developed a method that identifies Extreme Wildfire Periods (EWP) that form the basis for climate analysis. Synoptic analysis using Circulation Weather Types (CWT) showed that the northeasterly and easterly directional flows are significantly associated with EWP and produce the most severe fire‐weather conditions. The four main CWT related to extreme fire are driven from anticyclones over the eastern Atlantic between the Azores and the British Isles. However, severe situations can also be regulated by CWT with marginal presence in both summer and EWP: low systems located to the west and northwest of Iberia carrying air masses from the south quadrant are related to catastrophic events. Regarding the antecedent climate, the results indicate that the coincident meteorological drought, whether weak or intense, is a necessary but not sufficient condition for the development of an EWP. An increasing relevance of water stress for shorter intervals preceding EWP, in the order of days and weeks, is apparent. Following these results, fine dead fuel moisture thresholds related to transitions in fire behaviour in Portuguese landscapes are computed using a promising predictive moisture content model. Finally, the different methods used are summoned for the detailed analysis of an EWP starting under unusual synoptic circulation.
Efficacy of four nitrification inhibitors for the mitigation of nitrous oxide emissions under different soil temperature and moisture#
Authors: Guo Yafei , Naeem Asif , Becker‐Fazekas Stefan , Pitann Britta , Mühling Karl H. 
Published: October 2021

AbstractBackgroundNitrification inhibitors (NI) may be used to inhibit nitrous oxide (N2O) emissions from agricultural soils, but their efficacy could be strongly affected by soil temperature and moisture.AimsThis study investigated how different NI behave in a sandy soil under variable temperature and moisture levels, which currently remains unclear.MethodsEfficacies of four NI [dicyandiamide (DCD), 3,4‐dimethylpyrazole phosphate (DMPP), nitrogenous mineral fertilizers containing the DMPP ammonium stabilizer (ENTEC) and active ingredients: 3.00–3.25% 1,2,4‐triazole and 1.50–1.65% 3‐methylpyrazole (PIADIN)] were investigated in an incubation experiment under two soil temperatures (15 and 25°C) and two moisture levels [60% and 80% water‐holding capacity (WH)] for 60 days in a sandy soil. The soil received 0.5 g NH4+‐N kg−1 soil and the inhibitors were applied at 5% of applied N. Total N2O emissions were calculated based on gas samples collected throughout the incubation period.ResultsIncreasing soil temperature from 15 to 25°C decreased N2O emissions by 73–191% while increasing soil moisture from 60% to 80% WHC caused a 109–251% increase in the emissions. ENTEC followed by DCD were the least effective inhibitors to reduce N2O emissions under all temperature and moisture combinations. Depending upon temperature and soil moisture, DMPP and PIADIN inhibited 85–100% of N2O emissions. At 15°C, both DMPP and PIADIN almost completely inhibited N2O emissions. At 25°C, the efficacy of PIADIN decreased to 88%, while that of DMPP ranged from 86% to 98%. Increased soil moisture content improved the efficacy of all the NI.ConclusionsOverall, DMPP and PIADIN were more effective than DCD in a sandy soil under both the soil moisture levels and temperatures. DMPP was the most effective inhibitor, completely inhibiting N2O emissions at 15–25°C and up to 80% WHC in this soil, and is therefore recommended for use in agricultural lands. The concentration of the NI contained in ENTEC was insufficient to affect nitrification at the both soil moisture levels and temperatures.
A systematic review of socioecological factors, community violence exposure, and disparities for Latinx youth
Authors: Santacrose Diana E. , Kia‐Keating Maryam , Lucio Daniella 
Published: October 2021

AbstractCommunity violence exposure poses a public health risk exacerbated by immigration‐related stressors and environmental factors, including systemic racism and interpersonal discrimination, socioeconomic disparities, and anti‐immigrant laws and policies, that disproportionately impact Latinx‐immigrant and systematically minoritized youth. Using the ecological–transactional model of community violence as a conceptual framework, this systematic review was conducted to examine research on exposure to community violence, risk and protective factors, and associated health and mental health sequelae among Latinx youth. The initial search generated 2,152 articles, 291 of which were reviewed for detailed evaluation; ultimately, 59 articles were included. Mexican‐origin youth and adolescent samples were the most represented in research studies. Across several studies, Latinx youth reported high rates of violence exposure and poor health or mental health outcomes. The findings revealed important gaps in socioecological factors, with a dearth of evidence establishing macrosystem factors or culturally salient and immigrant‐related factors. Notable risk and protective factors at various ecological levels were identified and discussed as key opportunities for future research and points of intervention or prevention efforts for Latinx‐immigrant and systematically minoritized youth.
The end of the trial: Perspectives on cognitive processing therapy from community‐based providers in the Democratic Republic of Congo
Authors: Lakin Daniel P. , Murray Sarah M. , Lasater Molly E. , Kaysen Debra , Mataboro Amani , Annan Jeannie , Bolton Paul , Bass Judith K. 
Published: October 2021

AbstractDespite calls forincreased mental health programming in low‐resource and humanitarian contexts and effectiveness trials of psychotherapy in these settings, little research exists on the extent to which providers and recipients continue to practice skills learned during trials of these programs. To understand if and how providers continued to use mental health intervention skills without ongoing institutional support following the completion of randomized controlled trials (RCTs), we analyzed data from semistructured interviews with six of seven providers who participated in an RCT of cognitive processing therapy (CPT) in the Democratic Republic of Congo 7 years prior. Provider interviews revealed continued knowledge of and, in some cases, the practice of core CPT skills as well as efforts to keep meeting with women in the community and a strong desire to learn new skills. Although financial limitations sometimes prohibited providers from formally convening CPT groups with women in need, participants maintained knowledge and skill use. Providers also reported feeling more valued in their communities, and they continued providing services beyond the planned intervention period despite a lack of ongoing support. In addition, participants described a strong desire to continue psychosocial interventions for trauma and learn more about this type of intervention. Reframing the evaluation of psychological interventions as program development and maintaining a strong working relationship with community partners may allow for increased sustainability of mental health services beyond the end of academic research studies in low‐resource contexts.
Intergenerational maltreatment in parent–child dyads from Burundi, Africa: Associations among parental depression and connectedness, posttraumatic stress symptoms, and aggression in children
Authors: Charak Ruby , De Jong J.T.V.M. , Berckmoes Lidewyde H. , Ndayisaba Herman , Reis Ria 
Published: October 2021

AbstractStudies investigating the associations between histories of childhood maltreatment (CM) in parent–child dyads have primarily involved samples from high‐income countries; however, CM rates are higher in low‐ and middle‐income countries. The present study aimed to examine the (a) association between maltreatment in parents and maltreatment of their children through risk (i.e., parent depression) and protective (i.e., parent–child connectedness) factors and (b) associations between CM in children with aggression through posttraumatic stress symptoms (PTSS) and peer/sibling victimization. Participants were 227 parent–child dyads from Burundi, Africa, a low‐income country. Parents were 18 years of age or older, and children were 12–18 years (M = 14.76, SD = 1.88, 57.7% female). Among parents, 20.7%–69.5% of participants reported a history of physical and emotional abuse and neglect; among children, the rates of sexual, physical, and emotional abuse ranged from 14.5% to 89.4%. A history of CM in parents was associated with CM in children, B = 0.19, p < .01, and CM in parents was indirectly associated with CM in children through parent–child connectedness, β = .04, 95% CI [.01, .10], and parental depression, β = .08, 95% CI [.03, .15]. In children, maltreatment was positively associated with peer/sibling victimization, and CM was associated with aggression, β = .07, 95% CI [.04, 0.11], through PTSS but not via peer/sibling victimization. Continued efforts to improve CM‐related preventive strategies and the accessibility of prevention services are needed to reduce CM in low‐income countries such as Burundi.
Complication Risk in Ventral Skull Base Surgery Based on Preoperative Hematocrit
Authors: Flanagan Liam S. , Choi Chris B. , Lemdani Mehdi S. , Shah Aakash , Parray Aksha , Sukyte‐Raube Donata , Fang Christina H. , Baredes Soly , Eloy Jean Anderson 
Published: October 2021

Objectives/HypothesisPreoperative anemia has been shown to be a predictor of complications in different surgeries. This has not been exclusively studied in skull base surgery. This study investigates the impact of preoperative hematocrit on complications following ventral skull base (VSB) surgery.Study DesignRetrospective database review.MethodsThe National Surgical Quality Improvement Program was queried for all cases of VSB surgery from 2005 to 2015. Univariate and multivariate analyses were performed to investigate the impact of preoperative anemia on complications following VSB procedures.Results3,053 patients meeting inclusion criteria were identified. On univariate analysis, low hematocrit was found in 39.7% of patients and was associated with increased mean age (55.71 vs. 53.25 years), male gender (63.6% vs. 36.4%), and Black race (18.5% vs. 10.9%). Preoperative anemia was also associated with increased incidences of postoperative pneumonia, blood transfusions, sepsis, medical complications, surgical complications, extended length of hospital stay (LOS), and mortality. On multivariate analysis, associations between low preoperative hematocrit and perioperative transfusions (odds ratio [OR] 2.57, 95% confidence interval [CI] 1.88–3.50, P < .001), total surgical complications (OR 2.12, 95% CI 1.60–2.80, P < .001), and extended LOS (OR 1.29, 95% CI 1.05–1.57, P = .013) remained significant.ConclusionsLow preoperative hematocrit is associated with increased risk of postoperative complications and extended LOS in patients undergoing VSB surgery. This study highlights the importance of careful preoperative assessment and management of anemia in these patients.Level of Evidence3 Laryngoscope, 132:1707–1713, 2022
Impact of sustainable land‐use management practices on soil carbon storage and soil quality in Goa State, India
Authors: Paramesh Venkatesh , Singh Surendra Kumar , Mohekar Deepak S. , Arunachalam Vadivel , Misra Shiva Dhar , Jat Shankar Lal , Kumar Parveen , Nath Arun Jyoti , Kumar Nirmal , Mahajan Gopal Ramdas , Bhagat Tejasvi 
Published: October 2021

AbstractEvaluating sustainable land management (SLM) practices have regional to worldwide implications. It is imperative to develop SLM under particular soil type, climate, and cropping sequence following area‐specific best management practices to harness maximum profitability. The alternative land‐use system (ALUS—natural forest, pasture, cashew, areca nut, coconut) on hills and agricultural land‐use system (AGLUS—rice–rice, rice–pulse) in the coastal plains of Goa State in west coast India were evaluated in this study. This study assessed the impact of sustainable land‐use management practices on different fractions of soil organic carbon (SOC), its stock, and soil quality index (SQI) under the ALUS and AGLUS. The total SOC stocks under different land‐use systems varied from 14.4 Mg C ha−1 in rice–rice rotations to 133.7 Mg C ha−1 in cashew. The lability index, available nutrients, and biochemical properties were higher in ALUS. The variation in the levels of SOC and soil quality was due to land use and management practices. The results indicated land use with areca nut (SQI = 0.8) on the hills and rice–pulses (SQI = 0.25) rotations on the coast had maintained soil quality of high order. We recommend promoting sustainable agriculture with ALUS on the hills and AGLUS on the coastal plains of Goa State to enhance SOC storage, improve soil quality, and increase farmers' income.
Influence of Salt Doping on the Entropy‐Driven Lower Disorder‐to‐Order Transition Behavior of Poly(ethylene oxide)‐b‐Poly(4‐vinylpyridine)
Authors: Zhang Ze‐Kun , Ding Shi‐Peng , Zhou Yi‐Ting , Ye Ze , Wang Rui‐Yang , Du Bin‐Yang , Xu Jun‐Ting 
Published: October 2021

AbstractPoly(ethylene oxide)‐b‐poly(4‐vinylpyridine) (PEO‐b‐P4VP) block copolymers (BCPs) exhibiting lower disorder‐to‐order transition (LDOT) phase behavior are doped with different salts (LiCl, CuCl2, and FeCl3), in which both blocks can competitively associate with the metal ions. It is found that the entropy‐driven LDOT phase behavior of PEO‐b‐P4VP can be bi‐directionally adjusted by enthalpic interactions, depending on the complexation selectivity of metal ions toward two blocks and doping ratio (r). At low rs, Li+ ions preferentially interact with PEO block, leading to a decreased disorder‐to‐order transition temperature (TDOT). Cu2+ ions selectively complex with the P4VP block, and the TDOT first increases with increasing r, followed by a decrease. By contrast, Fe3+ ions interact strongly with both blocks, resulting in increase of TDOT. At high rs, the complexation selectivity becomes weaker, leading to reduced immiscibility and increased TDOT, as compared with the hybrids with low rs. The effects of metal cation and r on the LDOT phase behavior are qualitatively explained by the change of the Flory–Huggins parameter.
Modified MOF‐Based Composite All‐Solid‐State Polymer Electrolyte with Improved Comprehensive Performance for Dendrite‐Free Li‐Ion Batteries
Authors: Liu Yu , Zeng Qinghui , Chen Pingping , Li Zhenfeng , Chen Anqi , Guan Jiazhu , Wang Ailian , Zhang Liaoyun 
Published: October 2021

AbstractSolid‐state polymer electrolytes (SPEs) used for Li‐ion batteries have consistently received widely−attention owing to its high safety, excellent flexibility, and good compatibility with electrodes. However, pristine SPEs are difficult to satisfy all necessary demands for the practical applications in high‐performance Li‐ion batteries. Herein, a polycaprolactone modified metal‐organic framework (MOF‐PCL) composite polymer electrolyte (CSPE) is fabricated through the facile UV‐light induced photopolymerization of boronic ester crosslinking monomer (BEM) and poly (ethylene glycol) diacrylate (PEGDA) in the presence of lithium bis(trifluoromethanesulfonyl) imide (LiTFSI) and MOF‐PCL. The existence of MOF‐PCL in the electrolyte can not only obviously improve the ion conduction, but also enhance electrochemical stability simultaneously. Besides, the boron‐doped network structure can further promote the transport of Li‐ions. As a result, the obtained CSPE has a higher lithium‐ion transference number of 0.59 and a wide electrochemical window of 5.29 V. Moreover, the LiFePO4/Li cell based on this CSPE also exhibits excellent long‐cycling and rate performance. Undoubtedly, this study not only can provide a new designed method for SPEs with comprehensive performance, but also exhibits a good application potential of this modified MOF‐based CSPE with borate ester in the high‐performance Li‐ion batteries.