bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoradiographical assessment of inflammation-targeting radioligands for atherosclerosis imaging: potential for plaque phenotype identification
Authors: Meester Eric J. , de Blois Erik , Krenning Boudewijn J. , van der Steen Antonius F. W. , Norenberg Jeff P. , van Gaalen Kim , Bernsen Monique R. , de Jong Marion , van der Heiden Kim 
Published: March 2021

Abstract
Purpose
Many radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo signals is often limited to plaque identification. We evaluated binding of some promising radioligands in an in vitro approach in atherosclerotic plaques with different phenotypes.

Methods
Tissue sections of carotid endarterectomy tissue were characterized as early plaque, fibro-calcific plaque, or phenotypically vulnerable plaque. In vitro binding assays for the radioligands [111In]In-DOTATATE; [111In]In-DOTA-JR11; [67Ga]Ga-Pentixafor; [111In]In-DANBIRT; and [111In]In-EC0800 were conducted, the expression of the radioligand targets was assessed via immunohistochemistry. Radioligand binding and expression of radioligand targets was investigated and compared.

Results
In sections characterized as vulnerable plaque, binding was highest for [111In]In-EC0800; followed by [111In]In-DANBIRT; [67Ga]Ga-Pentixafor; [111In]In-DOTA-JR11; and [111In]In-DOTATATE (0.064 ± 0.036; 0.052 ± 0.029; 0.011 ± 0.003; 0.0066 ± 0.0021; 0.00064 ± 0.00014 %Added activity/mm2, respectively). Binding of [111In]In-DANBIRT and [111In]In-EC0800 was highest across plaque phenotypes, binding of [111In]In-DOTA-JR11 and [67Ga]Ga-Pentixafor differed most between plaque phenotypes. Binding of [111In]In-DOTATATE was the lowest across plaque phenotypes. The areas positive for cells expressing the radioligand’s target differed between plaque phenotypes for all targets, with lowest percentage area of expression in early plaque sections and highest in phenotypically vulnerable plaque sections.

Conclusions
Radioligands targeting inflammatory cell markers showed different levels of binding in atherosclerotic plaques and among plaque phenotypes. Different radioligands might be used for plaque detection and discerning early from vulnerable plaque. [111In]In-EC0800 and [111In]In-DANBIRT appear most suitable for plaque detection, while [67Ga]Ga-Pentixafor and [111In]In-DOTA-JR11 might be best suited for differentiation between plaque phenotypes.
Spatio‐temporal characteristics of meteorological drought under changing climate in semi‐arid region of northern Ethiopia
Authors: Yisehak Biniyam , Shiferaw Henok , Abrha Haftu , Gebremedhin Amdom , Hagos Haftom , Adhana Kelali , Bezabh Temesgen 
Published: March 2021

Abstract
Background
Below-normal availability of water for a considerable period of time induces occurrence of drought. This paper investigates the Spatio-temporal characteristics of meteorological drought under changing climate. The climate change was analyzed using delta based statistical downscaling approach of RCP 4.5 and RCP 8.5 in R software packages. The meteorological drought was assessed using the Reconnaissance Drought Index (RDI).

Results
The result of climate change projections showed that the average annual minimum temperature will be increased by about 0.8–2.9 °C. The mean annual maximum temperature will be also increased by 0.9–3.75 °C. The rainfall projection generally showed an increasing trend, it exhibited an average annual increase of 3.5–13.4 % over the study area. The projected drought events reached its maximum severity indicated extreme drought in the years 2043, 2044, 2073, and 2074. The RDI value shows drought will occurred after 1–6 and 2–7 years under RCP 4.5 and RCP 8.5 emission scenarios respectively over the study area. Almost more than 72 % of the current and future spatial coverage of drought in the study area will be affected by extreme drought, 22.3 % severely and 5.57 % also moderate drought.

Conclusions
Therefore, the study helps to provide useful information for policy decision makers to implement different adaptation and mitigation measures of drought in the region.
Development of regional foresight studies between 2000 and 2019: an overview and co-citation analysis
Authors: Amini Hamed , Jabalameli Mohammad Saeed , Ramesht Mohammad Hosein 
Published: March 2021

AbstractRegional foresight is one of the regional planning approaches that increase the ability to deal with uncertainty and changes. This study aims to provide an overview of regional foresight studies and domain map to evaluate their merits and defects and direct future studies in this field. For this purpose, 111 papers related to regional foresight were identified at the “Web of Science” in the period 2000 to 2019 and used as the basis for further analysis. These papers have been reviewed in various aspects. In addition, the domain map of regional foresight and its intellectual bases was drawn based on co-citation analysis of these papers and their 4194 references. The domain map includes five main clusters of research areas or intellectual bases for regional foresight: normative forecasting, participation, foresight in policy and strategy, innovation systems, and multi-level governance. Finally, the merits and defects of regional foresight studies are evaluated based on research results and some suggestions are provided for future studies.
Migration ecology of western gray catbirds
Authors: Mancuso Kristen A. , Fylling Megan A. , Bishop Christine A. , Hodges Karen E. , Lancaster Michael B. , Stone Katharine R. 
Published: March 2021

Abstract
Background
For many songbirds in North America, we lack movement details about the full annual cycle, notably outside the breeding season. Understanding how populations are linked spatially between breeding and overwintering periods (migratory connectivity) is crucial to songbird conservation and management. We assessed migratory connectivity for 2 breeding populations of Gray Catbirds (Dumetella carolinensis) west of and within the Rocky Mountains by determining migration routes, stopover sites, and overwintering locations. Additionally, we compared apparent annual survivorship for both populations.

Methods
We deployed 39 archival light-level geolocators and 21 Global Positioning System (GPS) tags on catbirds in the South Okanagan Valley, British Columbia, Canada, and 32 geolocators and 52 GPS tags in the Bitterroot River Valley, Montana, USA. These devices allowed us to determine migration routes, stopover sites, overwintering locations, and migratory connectivity. Migratory connectivity was quantified using Mantel’s correlation. We used mark-recapture of colour banded catbirds in both sites to estimate apparent annual survivorship.

Results
We retrieved 6 geolocators and 19 GPS tags with usable data. Gray Catbirds from both populations passed through the Rocky Mountains eastward before heading south towards their overwintering locations in northeastern Mexico and Texas. Stopover sites during fall migration occurred primarily in Montana, Kansas, Oklahoma, and Arkansas. Overwintering locations spanned Texas and 5 states in northeastern Mexico. Individual catbirds used up to 4 distinct sites during the overwintering period. Catbirds separated by almost 500 km during the breeding season overlapped during the non-breeding season, suggesting weak migratory connectivity among western populations (Mantel’s correlation = 0.013, P-value = 0.41). Catbird apparent annual survivorship estimates were higher in British Columbia (0.61 ± 0.06 females; 0.64 ± 0.05 males) than in Montana (0.34 ± 0.05 females; 0.43 ± 0.04 males), though the main driver of these differences remain unclear.

Conclusions
Our results provide high precision geographic details during the breeding, migration, and overwintering phases of the annual cycle for western Gray Catbirds. Notably, we found that western catbirds followed the Central Flyway as opposed to the Pacific Flyway. We document that catbirds used multiple sites over winter, contrary to the popular belief that this phase of the annual cycle is stationary for most songbirds.
Recent progress in the research of Angelica sinensis (Oliv.) Diels polysaccharides: extraction, purification, structure and bioactivities
Authors: Hou Chunyan , Yin Mingsong , Lan Ping , Wang Huiru , Nie Hui , Ji Xiaolong 
Published: March 2021

AbstractThe root of Angelica sinensis (Oliv.) Diels, a well-known Chinese herbal medicine, has been used historically as hematopoietic and anti-inflammatory agents for thousands of years. Recent phytochemistry and pharmacological studies have proved that polysaccharides are one of the major active ingredients in A. sinensis. It has been demonstrated that ASPs (A. sinensis polysaccharides) had various important biological activities, such as hematopoietic, hepatoprotective, hypoglycemic, anti-inflammatory, antitumor, and antioxidant activities. The purpose of this present review is to appraise previous and current literatures on the extraction, purification, structural characterization and biological activities of ASPs. In addition, the structure–activity relationship will be further explored and discussed. We believe that this review will provide a useful bibliography for the investigation, production, and application of ASPs in functional foods and therapeutic agents. Moreover, this review also highlights the challenges of investigation and future considerations for holistic utilization.
Hyporesponsiveness to long-acting erythropoiesis-stimulating agent is related to the risk of cardiovascular disease and death in Japanese patients on chronic hemodialysis: observational cohort study
Authors: Tanaka Kenichi , Fujiwara Momoko , Saito Hirotaka , Iwasaki Tsuyoshi , Oda Akira , Watanabe Shuhei , Kanno Makoto , Kimura Hiroshi , Tani Yoshihiro , Asai Jun , Suzuki Hodaka , Sato Keiji , Kazama Junichiro James 
Published: March 2021

Abstract
Background
Responsiveness to erythropoiesis-stimulating agents (ESAs) is thought to be related to prognosis in patients on hemodialysis. A multi-center, prospective cohort study was conducted to investigate the effects of hyporesponsiveness to long-acting ESAs on cardiovascular events and mortality in Japanese patients on chronic hemodialysis.

Methods
A total of 127 chronic hemodialysis patients treated with long-acting ESAs were followed-up prospectively. Responsiveness to ESA was evaluated using an erythropoietin resistance index (ERI) calculated by dividing the weekly body-weight-adjusted ESA dose by the hemoglobin concentration. The primary endpoint of this survey was defined as a combination of cardiovascular events and all-cause deaths. The association between hyporesponsiveness to ESAs evaluated by the highest quartile of the ERI and the primary endpoint was investigated.

Results
During the follow-up period (median 4.6 years), 32 patients reached the primary end point. Kaplan-Meier curve analysis showed that patients with ESA hyporesponsiveness belonging to the highest quartile of the ERI reached the primary end point more frequently than those without (P = 0.031). Cox regression analysis showed that an ERI in the highest quartile was an independent predictor of the primary end point, even after adjustment using a propensity score (hazard ratio 2.76, 95% confidence interval 1.19–6.40).

Conclusions
ESA hyporesponsiveness in hemodialysis patients treated with long-acting ESAs is related to cardiovascular events and death.
The effects of life style modification versus food supplementation on menopausal symptoms
Authors: Fouad Suzanne , El Shebini Salwa Mostafa , Ahmed Nihad Hassan , Hussein Ahmed Mohamed Saied , Essa Hend Abbas , Abdel-Moaty Maha , Tapozada Salwa Tawfic 
Published: March 2021

Abstract
Background
Nutrition and good health are two dependent parallel axes; female’s health at different ages in general and at the time of menopause in particular has received a lot of attention last several years. The objective of this experimental study was to evaluate the effect of consuming food supplement versus lifestyle modification in the dietary habit on menopausal symptoms in perimenopausal Egyptians females.

Results
Forty seven females in the perimenopausal stage of life with mean age 46.04 ± 5.88 years participated on the food supplement consumption group, they consumed 75 g per day of a rusk (prepared from corn flour, wheat flour 72%, full cream milk powder, flaxseed oil, wheat germ, clove and cinnamon powder) for 2 months. They were compared with the control group (forty nine females with mean age 46.91 ± 5.39 years) who changed their foods habits to a healthy life style. Menopause rating scale and the biochemical analysis were comparable on day 1 and on day 60. The total menopause rating scale and its three subscales (psychological, urogenital and somatic), waist circumference, serum follicle stimulating hormone and estradiol in the corn rusk supplement group showed a statistically significant improvement. No significant difference was noted in the control group apart of the psychological subscale and waist circumference.

Conclusions
Corn Rusk enriched with clove and cinnamon as a food supplement snake is promising to relief menopausal symptoms and should be considered on the diet of menopausal females.
Influence of sulfur coated urea and algae fertilization on productivity of some leguminous crops in sandy soils
Authors: Essa Reda , Afifi Ahmed , Ashry Soad 
Published: March 2021

Abstract
Background
This studies the influence of algae and coated urea fertilization on the productivity of some leguminous crops in order to reach the best methods of fertilization to get on highest productivity in sandy soils.

Results
The results proved that both yield and its components a better result in the focus of the SCU + algae than utilizing sulfur-coated fertilizers and algae in both seasons. A large amount extreme yield and straw yield were established with the algae treatment. The outcomes uncovered that SCU + algae improved plant productivity and quality soybean and mungbean seeds. The utilization of SCU + algae expanded protein, carbohydrates and oil %, compared with sulfur-coated urea and algae.

Conclusion
Along these lines, it could be finished from the results that of SCU + algae with 60 kg N/fed observed to be the best portion to accomplish or gain with exertion the greatest quality.
Risk for osteoporotic fractures in patients with atrial fibrillation using different oral anticoagulants
Authors: Kim Daehoon , Yang Pil-Sung , Sung Jung-Hoon , Jang Eunsun , Yu Hee Tae , Kim Tae-Hoon , Uhm Jae-Sun , Kim Jong-Youn , Pak Hui-Nam , Lee Moon-Hyoung , Lip Gregory Y. H. , Joung Boyoung 
Published: March 2021

Abstract
Background
We aimed to investigate the comparative risk of fracture among patients with atrial fibrillation (AF) treated with warfarin or non-vitamin K antagonist oral anticoagulants (NOACs).

Methods
Using the Korean National Health Insurance Service database, patients with AF who received a prescription for apixaban, dabigatran, rivaroxaban, or warfarin between 2013 and 2016 were included. Risk of major fractures (osteoporotic hip, vertebral, or pelvic fractures) were compared using inverse probability of treatment weighting.

Results
There were 70,481 patients identified (41.3% women; mean [SD] age 70.5 [11.3] years); 16,992 apixaban, 22,514 dabigatran, 27,998 rivaroxaban, and 29,390 warfarin users. During a median follow-up of 390 days, 2412 major fractures occurred with weighted incidences per 100 patient-years of 2.56 for apixaban, 2.39 for dabigatran, 2.78 for rivaroxaban, and 3.43 for warfarin. NOAC use was associated with a lower risk for fracture than warfarin use: HR 0.70 (95% confidence interval [CI] 0.57–0.86) for apixaban, HR 0.69 (95% CI 0.60–0.78) for dabigatran, and HR 0.79 (95% CI 0.70–0.90) for rivaroxaban. In head-to-head comparisons between NOACs, there was no significant difference between apixaban and dabigatran. Rivaroxaban was associated with a higher risk for fracture than dabigatran (HR 1.15, 95% CI 1.02–1.31).

Conclusion
In patients with AF, NOAC use may result in a lower risk for osteoporotic fracture compared with warfarin use. Fracture risk does not seem to be altered by the choice of NOAC type, except for rivaroxaban. These associations may help inform benefit–risk assessments when choosing between the different anticoagulant types.
Therapeutic role of corticosteroids in COVID-19: a systematic review of registered clinical trials
Authors: Raju Reshma , V. Prajith , Biatris Pratheeksha Sojan , J. Sam Johnson Udaya Chander 
Published: March 2021

Abstract
Background
In March 2020, the World Health Organization declared the coronavirus disease 2019 as a global pandemic. Though antiviral drugs and antimalarial drugs are considered treatment options for treating coronavirus disease 2019 (COVID-19), no specific antivirals are currently available for its treatment. Efficient use of drug discovery approaches including repurposing or repositioning of drugs used in the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) is considered recently. The widespread application of corticosteroid therapy in COVID-19 should be backed with careful documented pragmatic research of its use in this context.

Main body
This article aims to analyze various trials registered across the globe providing an overall picture of the use of corticosteroids in the treatment of COVID-19. An extensive search was conducted on the clinical trial registries around the world to identify all the trials reporting information regarding the use of corticosteroids in COVID-19. Our initial search returned 231 trials, out of which 60 trials were finally included in the analysis. Fifty-six studies were interventional trials, and all the trials had clearly defined primary and secondary outcomes of interest, of which only 11 trials had evaluation of respiratory rate as one of their outcomes.

Conclusion
Few preliminary trial findings show promising results and recommend the use of methylprednisolone and dexamethasone in the severe form of the disease; however, there is insufficient data to prove its benefits over its risks. Routine use of corticosteroids should be favored only after a better insight is obtained, with the completion of these trials.
Neonatal minimal invasive management of a prenatal gunshot trauma: case report
Authors: Ruhrnschopf Camila Gonzalez , Reusmann Aixa , Boglione Mariano , Arbio Soledad , Barrenechea Marcelo 
Published: March 2021

Abstract
Background
Prenatal penetrating gunshot trauma represents a challenging scenario for healthcare providers. Trauma is the leading non-obstetric cause of morbidity and mortality during pregnancy, and even though rare, firearm injuries have the most fatal outcomes and higher fetus mortality rates. Understanding the mechanism of injury in order to identify the possible injuries and adequate management is essential. In this paper, we discuss the case of a newborn with prenatal gunshot trauma, the treatment used, and the outcome of conservative and minimally invasive management.

Case presentation
We present the case of a male newborn, 37 weeks of gestational age and weighing 3050 g, delivered through an emergency cesarean section with prenatal gunshot trauma. Two skin wounds were found, one in the arm and another in the left thoracic region. The patient presented with respiratory distress, bilateral pneumothorax, and pneumoperitoneum, requiring high-frequency mechanical ventilation and the placement of bilateral thoracic drains. The pneumoperitoneum was attributed to pulmonary barotrauma, with no suspicion of abdominal hollow viscera lesion. A right thoracoscopy was performed after 24 h of conservative management for the removal of the foreign body. Both the mother and the baby had a positive outcome, with no further treatment needed.

Conclusions
For the improvement in the result of trauma events, an adequate intervention and coordinated efforts from multidisciplinary clinical and surgical teams are required. For gunshot wounds, entry, trajectory, the final position of the bullet, and pathological findings in images need to be analyzed before taking the patient to the operative room. Chosen with strict selection criteria, some patients could benefit from conservative management.
EPA guidance on treatment of negative symptoms in schizophrenia
Authors: Galderisi S. , Kaiser S. , Bitter I. , Nordentoft M. , Mucci A. , Sabé M. , Giordano G. M. , Nielsen M. Ø. , Glenthøj L. B. , Pezzella P. , Falkai P. , Dollfus S. , Gaebel W. 
Published: March 2021

AbstractNegative symptoms of schizophrenia remain a major therapeutic challenge. The progress in the conceptualization and assessment is not yet fully reflected by treatment research. Nevertheless, there is a growing evidence base regarding the effects of biological and psychosocial interventions on negative symptoms. The importance of the distinction between primary and secondary negative symptoms for treatment selection might seem evident, but the currently available evidence remains limited. Good clinical practice is recommended for the treatment of secondary negative symptoms. Antipsychotic treatment should be optimized to avoid secondary negative symptoms due to side effects and due to positive symptoms. For most available interventions, further evidence is needed to formulate sound recommendations for primary, persistent, or predominant negative symptoms.However, based on currently available evidence recommendations for the treatment of undifferentiated negative symptoms (including both primary and secondary negative symptoms) are provided. Although it has proven difficult to formulate an evidence-based recommendation for the choice of an antipsychotic, a switch to a second-generation antipsychotic should be considered for patients who are treated with a first-generation antipsychotic. Antidepressant add-on to antipsychotic treatment is an option. Social skills training is recommended as well as cognitive remediation for patients who also show cognitive impairment. Exercise interventions also have shown promise. Finally, access to treatment and to psychosocial rehabilitation should be ensured for patients with negative symptoms. Overall, there is definitive progress in the field, but further research is clearly needed to develop specific treatments for negative symptoms.