bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benralizumab: eficacia y seguridad en pacientes con asma grave eosinofílica.
Authors: Chaia Genny , Martín Ubaldo , Cortés-Telles Arturo , Morett Fernando , Gutiérrez-Mujica José Julio , Zepeda-Gómez Adriana , Hegewisch Alberto , Hernández Rogelio Ramses 
Published: January 2021

ResumenEl asma grave conlleva una carga de salud desproporcionadamente alta y cerca de la mitad de los adultos con esta patología tiene un fenotipo eosinofílico. En estos pacientes aunado a la producción de eosinófilos en médula ósea, se activan mecanismos de eosinopoyesis local en tejido pulmonar. Benralizumab es un anticuerpo monoclonal humanizado, que se une con alta afinidad y especificidad a la subunidad alfa del receptor de IL-5 (IL-5Rα) sobre la superficie de eosinófilos y otras células. El principal diferenciador de su mecanismo de acción se relaciona con la remoción de un residuo de fucosa en la Fc, lo cual incrementa hasta 50 veces la afinidad a células NK con apoptosis de eosinófilos mediante citotoxicidad celular dependiente de anticuerpos (CCDA), resultando en una reducción rápida y cercana al 100% tanto en suero como en médula ósea. Adicionalmente, benralizumab reduce >90% de los eosinófilos en tejido pulmonar y esputo. En diversos estudios clínicos controlados y en vida real se ha demostrado que esto se traduce en incremento actual del control del asma y disminución del riesgo futuro. El perfil de seguridad es adecuado sin haberse documentado infestaciones parasitarias ni efectos adversos a largo plazo relacionados con la reducción de los eosinófilos. Abstract Severe asthma carries a disproportionately high health burden and about half of adults with this pathology have an eosinophilic phenotype. In these patients, in addition to the production of eosinophils in bone marrow, local eosinopoiesis mechanisms are activated in lung tissue. Benralizumab is a humanized monoclonal antibody, which joins with high affinity and specificity to the alpha subunit of the IL-5 receptor (IL-5Rα) on the surface of eosinophils and other cells. The main differentiator of its mechanism of action is related to the removal of a fucose residue in Fc, which increases up to 50 times the affinity to NK cells with eosinophil apoptosis by antibody-dependent cell cytotoxicity (CCDA), that leads to a direct, rapid and nearly complete depletion in both peripheral blood and bone marrow. Additionally, benralizumab reduces >90% of eosinophils in lung tissue and sputum. Several controlled and real-life clinical studies have shown that this action over eosinophils is related to increased asthma control and decreased future risk. The safety profile is adequate without documenting parasitic infestations or long-term adverse effects related to the reduction of eosinophils.
Lyrics and Existence in Scientific and Poetic Knowledge
Authors: Morkina Julia S. 
Published: January 2021

In the article, science and poetry, scientific and poetic creativity are considered as part of human culture. It is shown that both scientific and poetic activities are loaded with cognitive content. At the same time, if the thesis about the cognitive orientation of science is not in doubt, then the connection of art with knowledge is not so obvious and needs explication. Poetry is considered as cultural phenomena that are directly related to knowledge, to the cognitive component of human activity. Poetry and science can be compared on the basis of their direct relationship to the emotional environment of human existence and the existential feelings experienced by the subject of knowledge. In the article, we evaluate the concept of intellectual emotion, which was introduced by members of the Kharkiv linguistic school for the analysis of human cognitive activity in culture. For analysis of existential feelings, we review the conditions of self-awareness of both scientific and poetic activity. Special attention is paid to the analysis of apperception of the complex poetic contents of the consciousness of both poet and reader-interpreter as his co-author. Considering the views of E. Husserl and A. Bergson as well as the views of members of the Kharkiv linguistic school, we discuss the theoretical and cognitive aspect of poetic creativity. In the article, we conclude about a person’s holistic perception of knowledge, which is not only appercepted by the human mind but also affects his emotional sphere. We have shown that there are intellectual emotions involved in the consciousness of a person who solves a complex scientific or philosophical problem as well as perceiving poetry that has an cognitive aspect. We also concluded that existential emotions and feelings play a significant role in cognition. Therefore, knowledge can be not only scientific or philosophical but also poetic, and in the latter form of knowledge the existential aspects are more clearly manifested.
The ANALYZING THE ACCOUNTING INFORMATION SYSTEM SALES CASH IN IMPROVE THE EFECTIVITY SALES
Authors: Mauliyah Nur Ika 
Published: January 2021

The aims of this research are: Analyzing the Accounting System of cash sales implemented at UD. Tani Mulyo with Accounting System whether it is appropriate theory. This research is a case study (1) Describing the cash sales activities and describing functions, procedures, documents, accounting records for cash sales, (2) Provide comparisons to Accounting Information System applied to SIA according to the theory adapted (3) Create Flowchart in accordance with existing procedures. Based on the analysis it could be concluded that: (1) The existence of overlapping tasks and responsibilities in the work on related functions. (2) The absence of Accounting Information System and Flowchart. (3) Document usage and accounting records in the accounting system is still simple and manual. (4) Although the sales are done smoothly, but in accordance with the system and procedures appropriate for use in the company will further improve the effectiveness of the sales activities. With the increase in sales effectiveness, the company's results are also increasing.
Penghentian Konsumsi Alkohol Pada Remaja Dengan Langkah Menerapkan Germas
Authors: Putri Laurent Nadia Asmoro 
Published: January 2021

GERMAS adalah sebuah gerakan yang bertujuan untuk memasyarakatkan budaya hidup sehat serta meninggalkan kebiasaan dan perilaku masyarakat yang kurang sehat. Aksi GERMAS ini juga diikuti dengan memasyarakatkan perilaku hidup bersih sehat dan dukungan untuk program infrastruktur dengan basis masyarakat.Perilaku konsumsi alkohol kini sudah menjadi kebiasaan semua komunitas baik di dunia maupun di Indonesia, tidak heran apabila alkohol kini mulai merambah ke generasi muda, terutama remaja. Rasa ingin mencoba hal baru yang dimiliki remaja kini mendorong remaja untuk mengkonsumsi alkohol. Tentu saja hal ini dapat merusak mental maupun psikis dari remaja itu sendiri. Penyalahgunaan minuman keras saat ini merupakan permasalahan yang cukup berkembang di dunia remaja dengan prevalensi yang sangat tinggi. sebesar 61,7% dari penduduk berusia 15 tahun atau lebih tua (15+) di seluruh dunia pernah minum alkohol dalam 12 bulan terakhir, bahkan sekitar 16,0% adalah peminum berat.
Analysis of elastic behaviour of granite using homogenisation theory
Authors: Baek Y. , Kweon O. I. , Seo Y. S. , Kim K. S. , K im G. W. 
Published: January 2021

We carried out photographic analysis of randomly distributed discrete elements in the lnada granite. The modal analysis of granite was also conducted simultaneously with the above photographic analysis. The results show that quartz and feldspar including mica occupy 99.4% of the total volume of the fine-grained granite. Based on the results of previous studies, an elastic homogenisation method is applied to analyse the macro-level stress distribution in the lnada granite, which is a composite material of rock-forming minerals with micro discontinuities.
For proper rock sampling and specimen preparation, the representative elementary volume (REV) should be determined in rock mechanical tests and numerical analyses. We determined the REV of the lnada granite using a stereoscopic microscope and applying a homogenisation numerical analysis.
Adsorption of nitrate as a groundwater pollutant by soil particles
Authors: Nakayama Chieko , Tanaka Yoshinori 
Published: January 2021

This study discusses nitrogen adsorption in several soil samples of the Kanto loam collected from two locations in the Kanto plain. Their chemical properties were assessed on each of the soil samples as well as on pure allophane clay by instrumental analysis using batch and soil column tests.
Nitrogen-nitrate adsorption by soil samples was determined by a 10-hour batch test using a nitric acid solution of 0.14 mmol. A saturation column test was conducted to obtain a breakthrough curve and calculate the coefficients of dispersion and retardation. The extent of nitrate adsorption in soil samples was confirmed by percolation with 0.14 mmol nitric acid through columns packed with the soil sample and silicate sand.
In the batch test, it was found that the amount of nitrate adsorption was greater in allophane-rich volcanic ash soils with the amount of nitrate adsorption increasing under conditions of low pH. The breakthrough curve determined by the column test showed that the coefficient of retardation increased in allophane-rich soils.
Adsorption of nitrates by Kanto loam soils was thus found to be dependent upon the content of allophane and amorphous material in the soil. Since the positive charge of allophane has the potential to reduce the nitrate content in groundwater, it can be effectively applied to reduce nitrate contamination in groundwater.
Utracone, poszukiwane i odzyskane dziedzictwo kulturowe Łodzi przemysłowej na przykładzie Art_Inkubatora w Fabryce Sztuki*
Authors: Moreno-Kamińska Natalie 
Published: January 2021

Over the past 25 years, Łódź has seen an evolution in attitude towards the city’s post-industrial heritage, both material and non-material. Exemplifying these processes of loss, seeking, and retrieval is Art_Inkubator, a complex of 19th-century factories in the city’s central district of Księży Młyn that once belonged to Karol Scheibler and Ludwik Grohman. The goal of the project, carried out by a municipal cultural institution known as Fabryka Sztuki, has been to revitalize and adapt former factory buildings, including them in its incubator program dedicated to the support of activities within the creative industries sector. Another cultural heritage site known as MuseumABC is also located in this area. Fabryka Sztuki’s efforts have preserved the factory buildings as part of the city’s cultural heritage and made it possible to put their historic features to good use in the development of innovative and creative activities. After decades of neglect, the characteristic red-brick buildings have beengiven “new life” as centres of culture and business enterprise.
Niematerialne dziedzictwo kulturowe w kontekście badań nad kontaktami i sieciami społecznymi
Authors: Drápala Daniel 
Published: January 2021

This article discusses the use of the concept of social capital in relation to the elements of intangible cultural heritage (ICH) and the need to protect it. At the outset, the author examines theoretical concepts which researchers have employed, in past decades, outside the area of ethnological studies. The article highlights one of the basic principles, that of social capital, which consists in sharing real and potential sources, knowledge, and information, which an individual person or group acquires through relations that may to some degree be characterized as institutional. Based on experiences gathered both in a national context (the Czech Republic) and within that of an international organization (UNESCO), the article attempts to assess the extent to which it is possible to apply the theoretical foundations of the idea of the social capital to ICH, where the principles of the sharing of and mutual respect towards cultural elements are two of the basic premises.
Phase Transformations
Authors: Kennon Noel F. 
Published: January 2021

Abstract
This chapter describes some of the most essential tools in metallurgy and what they reveal about the structure, composition, and processing requirements of steel. It begins by identifying important details in the constitutional diagram of iron-cementite. It then explains how to read isothermal transformation and continuous-cooling diagrams and how to recognize the effect of various alloying elements.
STAR WARS: lições contra a atual ameaça invisível à República
Authors: Santo Júlio Edstron Secundino , Suxberger Antonio Henrique Graciano 
Published: January 2021

A saga Star Wars é um fenômeno mundial multibilionário, ela é um largo fenômeno da cultura global, formada por filmes, livros, jogos eletrônicos e brinquedos. Enquanto prodígio mundial, essa franquia pode ser utilizada como instrumento metodológico para discussões atuais que perpassam questões jurídicas, internas e internacionais, sobre a efetivação dos direitos humanos e fundamentais. Enquanto ferramenta para debates, os produtos derivados pela saga Guerra nas Estrelas possibilitam o acesso a diálogos que aproximam as pessoas, por terem oportunidade de compartilhar a mesma experiência. Neste sentido, a pesquisa teve como problematização, como a franquia Star Wars pode ser utilizada como instrumento pedagógico. O objetivo geral é demonstrar que aquele conjunto narrativo ficcional pode ser utilizado como um instrumento pedagógico para reflexões sobre diversas situações complexas hodiernas, como a proteção dos direitos essenciais ou a erosão da democracia ocidental. Para tanto, foram utilizados os métodos hipotético dedutivo e a técnica de revisão bibliográfica. Assim, buscando utilizar expressões próprias dos filmes e livros, serão conectados os problemas da atualidade à ficção criada originalmente por George Lucas.
Anthropological Foundations of Global Education
Authors: Gzegorczyk Andrzej 
Published: January 2021

The first Ukrainian translation of the text by Andrzej Grzegorczyk "Anthropological Foundations of Global Education".
Andrzej Grzegorczyk (1922-2014) asks the question: is the current construction of the world educational system theoretically justified in terms of human cognitive needs in the modern world, and does it have prospects for development? The theoretical starting point for the rational substantiation of the construction of a modern educational program needed in our era can be represented by distinguishing two components of the picture of human life: 1) stages of development of knowledge of the child and 2) branches (spheres) of human activity to which the school should prepare.
Andrzej Grzegorczyk offers his own vision of the sequence of formation of the student's personality. Based on the achievements of socio-evolutionary psychology, he proposes to correlate ontogenesis and phylogeny in education. The young human individual goes, in particular, through successive phases of development, in each of which in turn is dominated by the following four educational and developmental processes initiated by the natural human environment (as well as school). The stages of learning correspond, thus, to the prospects of student development: from the narrowest (family-tribal) perspective to the universalist, which is a synthesis of what tradition brings, as well as acquired knowledge and development of a sense of universal values. Thus, the stages (levels) of education can, in his opinion, be called as follows: 1) family-tribal, 2) traditionally national-religious, 3) individual-rationalist-scientific, 4) universalist-synthetic.
The second dimension of the education program is the field / field of study. Presenting the problems of creative realization of values ​​in public life, they can be arranged according to certain parameters: guidelines for activity, way of seeing one's place in society, forms (mechanisms) of action to which the individual is usually subject or implements at this stage, related norms and positions. Among the positions of special attention deserves the experience of self-worth. In the formation of the educational system should include in the content of education the following topics related to culture, the following parameters: type of culture, the main idea of ​​culture of this type, characteristics of the richness of cultural production of this type and related type of knowledge.
Nilai Strategis Komoditas Unggulan Kawasan Perdesaan, Kabupaten Pesisir Selatan, Provinsi Sumatera Barat
Authors: Anggarawati Sari , Suwarnata Anak Agung Eka 
Published: January 2021

Sektor pertanian di Kabupaten Pesisir Selatan masih merupakan ujung tombak pembangunan perdesaan untuk meningkatkan pertumbuhan ekonomi dan penyerapan tenaga kerja. Dalam rencanaan pembangunan kawasan perdesaan (RPKP) diperlukan identifikasi dan analisis potensi komoditas unggulan daerah perdesaan. Tujuan dari penelitian ini adalah melakukan identifikasi potensi pengembangan komoditas unggulan Kabupaten Pesisir Selatan, melakukan penilaian kontribusi produksi hasil komoditas unggulan dibandingkan komoditas lainnya, melakukan analisis peluang penyerapan tenaga kerja pada komoditas unggulan dan melakukan analisis studi kelayakan dalam peningkatan pendapatan dan pengurangan kemiskinan. Metode penilaian yang digunakan adalah membandingkan dua kondisi, yaitu saat sebelum ada RPKP dan setelah ada kegiatan RPKP. Sebelum ada kegiatan RPKP, pertumbuhan ekonomi kawasan mengikuti kondisi alamiah yang telah ada tanpa ada campur tangan. Sedangkan kondisi setelah RPKP adalah kondisi ekonomi kawasan setelah ada upaya bantuan untuk mempercepat pertumbuhan ekonomi di kawasan tersebut. Nilai produksi komoditas menunjukkan bahwa ternak sapi, tanaman pangan padi, tanaman hortikultura cabai dan perkebunan kelapa sawit adalah komoditas yang memiliki nilai kontribusi ekonomi tertinggi di masing-masing kelompok komoditas. Tanaman pangan memberikan kontribusi tertinggi senilai Rp2.608.210.710.000,00 tahun 2022, juga dalam serapan tenaga khususnya pertanian tanaman pangan. Hasil perhitungan kelayakan investasi pengemukan sapi membutuhkan biaya operasional dalam satu tahun adalah sebesar Rp110.272.000,00, nilai NPV sebesar Rp67.212.930,00, R/C rasio sebesar 2,56, dan Net B/C menunjukkan angka sebesar 1,56 selama umur usaha 5 tahun.
Authority, Personality and its Effects on Conflict Resolution Behaviour among Students of Istanbul Bilgi University
Authors: Gul Arif Ayesha , Czukor Gergely 
Published: January 2021

The aim of this experimental study was to examine how undergraduate students as participants resolve a conflict in response to authority status manipulation of the opponent person (low: a fellow student; high: a university professor), considering the moderating role of participants’ personality traits. 320 Psychology undergraduate students from Istanbul Bilgi University, aged 19-23 participated in an online survey. The participants first completed the Turkish version of the NEO-FFIand then they completed the modified Turkish version of the Thomas-Kilmann Mode Instrument (TKI). It was hypothesised that highly agreeable participants who were faced with a professor in a conflict would show a accommodating resolution style. Whereas extroverted participants who faced a fellow student inwere predicted to displaycompetitiveness in the conflict. A moderated regression analysis was applied. The results showed the opposite effects, students who were in conflict with the professor were more competitive and students who were in conflict with fellow students showed more accommodation. Limitations and future research possibilities are also discussed.
Toltrex for the treatment of eimeriosis of lambs
Authors: Aliev Ayub Yu. , Abdulmagomedov Suleman Sh. , Bakrieva Rabiyt M. 
Published: January 2021

Eimeriosis of small ruminants is an economically significant disease. A large percentage of lambs are susceptible to this protozoal disease at an early age. Acute eimeriosis can increase susceptibility to other intestinal infections. Eimeria, once in the body of an animal, cause a disturbance in the digestive processes, weaken the resistance of the body of lambs, and thereby also become a factor contributing to the occurrence of various infectious and helminthic diseases in small ruminants. Therefore, it is necessary to keep this protozoal disease under control. Coccidia are able to quickly form resistance to anticoccidial drugs, therefore, during therapy, it is necessary to periodically rotate anticoccidial drugs, as well as to carry out practical experimental work with new drugs in order to increase the effectiveness of veterinary measures.Material and methods. In a production experiment for the treatment of eimeriosis of lambs, the drug Toltrex 5% in the form of a suspension for oral administration produced by VIC-Animal Health was taken. It contains the active ingredient toltrazuril — 50 mg, as well as auxiliary components up to 1 ml. The drug has a wide spectrum of anticoccidial action and is effective against Eimeria arloingi, Eimeria scabra, Eimeria guevarai and other types of coccidia parasitizing in lambs and kids. The finely dispersed molecule of the active substance and the uniform distribution of toltrazuril in the suspension ensure high bioavailability and prolongation of the preparation in the animal’s body. After oral administration of the drug, the active substance toltrazuril is slowly absorbed in the gastrointestinal tract and has a coccidiocidal effect at the stage of intracellular development of the parasite. In the body, it is partially metabolized by sulfooxidation and hydroxylation, with the formation of derivatives of sulfoxide and sulfone. Toltrazuril is excreted from the body mainly unchanged (70%), as well as in the form of metabolites with feces and partly with urine.Results. As a result of the studies carried out, Toltrex® showed a high therapeutic efficacy of 90% for eimeriosis of lambs in the conditions of the grazing period.
Genetic markers of meat productivity of the Romanov sheep breed: IGFBP-3, GHo и CAST
Authors: Kostylev Mikhail N. , Abramova Marina V. , Ilyina Anna V. , Barysheva Maria S. , Malina Yulia I. , Evdokimov Evgeny G. , Yuldashbaev Yusupzhan A. , Chylbak-ool Salbak O. , Abdulmuslimov Abdulmuslim M. 
Published: January 2021

Relevance and methods. For molecular genetic analysis, samples taken from Romanov sheep in micro-populations of the Yaroslavl region from the ear by pluck were isolated. Polymorphism of genes of the type 3 protein that inhibits insulin-like growth factor (IGFBP-3), growth hormone (Gh), and calpastatin (CAST) in micro-populations of Romanov sheep of the Yaroslavl region was studied. A selection and genetic assessment of live weight indicators of sheep by age periods, depending on the genotype, was carried out.Results. Two variants of IGFBP-3 gene polymorphism were identified: homozygote (FF) and heterozygote (FG). The frequency of F and G alleles was 94% and 6%, respectively No animals carrying the gg genotype were identified in the study population. Evaluation of gene polymorphism in the population GHo Romanov sheep showed the presence of three genotypes AA, AB and BB with frequency of allele A and b — 63% and 37%, respectively. When evaluating the CAST gene polymorphism, 3 MM, MN, and NN genotypes were identified with different frequency of occurrence. The ratio of M and N alleles in the population was 74% and 26%, respectively. Indicators of observed (Ho) and expected (He) heterozygosity for the studied genotypes are in the range of 0.11...0.62 and 0.10...0.47, respectively. It was found that animals with the IGFBP-3FG genotype had a significantly higher live weight at the age of 10 months compared to carriers of the IGFBP-3FF genotype by 5.7%. For the GHo gene, the greatest significant superiority in live weight in all the studied age periods was found in individuals with the GHoAB genotype, which ranged from 0.5% to 12.9%. Animals with the CASTMM genotype outperformed animals with the CASTMN and CASTNN genotypes at 5 months of age by 5.61% and 14.8% and at 10 months of age by 4.53% and 11.3%, respectively. The conducted research will speed up the selection process and increase the profitability of the industry.