bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary central nervous system diffuse large B‐cell lymphoma masqueraded as Bing‐Neel syndrome: Steps in management and review of future directions
Authors: Delasos Lukas , Phachu Deep , Shetty Nishka , Sepulveda‐Ramos Melissa , Vredenburgh James 
Published: December 2021

AbstractBing‐Neel syndrome (BNS) remains a rare complication of Waldenstrom Macroglobulinemia. Given the paucity of this disease, treatment guidelines are based on small clinical trials with limited participants. Here, we present a case of primary CNS diffuse large B‐cell lymphoma masqueraded as BNS that developed while on ibrutinib therapy.
Building a smart traffic light system based on Internet of Things using ‐calculus
Authors: Vu Tuan‐Anh , Pham‐Quoc Cuong 
Published: December 2021

AbstractTraffic is very terrible in most big cities. These cities need many traffic police to control traffic congestion. They can change the duration of traffic lights to reduce levels of congestion of corners. However, the time changed by them is determined just only the feeling of themselves. Making decisions suitable for current congestion at that moment is not trivial. The resistant questions are how to define the logical time of traffic lights or how is an effect of this corner to the consecutive one. Maybe we need to increase the time of the green light at the next corner because of the traffic jam at this corner. The link between two corners is interaction inside concurrent processes. Besides, some exceptional cases also need to be handled, for instance, ambulances or fire trucks. The green light needs to be turned on when they come, and turn back the red light state later. This article proposes a tentative approach that uses context types, including locations, priorities of cars, velocity, and remaining time (the car comes to the corner) to determine traffic light periods. The context‐aware is applied in the infrastructure of the Internet of Things when transferring information to the corner. Maybe, in the future, the other systems such as Arduino, Raspberry pi, or other embedded systems will be joined in the designs as acting part (turn the traffic lights on/off ) and communicating role (connecting to the Internet via wifi) to control the duration of the traffic lights.
Laboratory Maintenance of the Chytrid Fungus Batrachochytrium dendrobatidis
Authors: Prostak Sarah M. , Fritz‐Laylin Lillian K. 
Published: December 2021

AbstractThe chytrid fungus Batrachochytrium dendrobatidis (Bd) is a causative agent of chytridiomycosis, a skin disease associated with amphibian population declines around the world. Despite the major impact Bd is having on global ecosystems, much of Bd’s basic biology remains unstudied. In addition to revealing mechanisms driving the spread of chytridiomycosis, studying Bd can shed light on the evolution of key fungal traits because chytrid fungi, including Bd, diverged before the radiation of the Dikaryotic fungi (multicellular fungi and yeast). Studying Bd in the laboratory is, therefore, of growing interest to a wide range of scientists, ranging from herpetologists and disease ecologists to molecular, cell, and evolutionary biologists. This protocol describes how to maintain developmentally synchronized liquid cultures of Bd for use in the laboratory, how to grow Bd on solid media, as well as cryopreservation and revival of frozen stocks. © 2021 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Reviving cryopreserved Bd culturesBasic Protocol 2: Establishing synchronized liquid cultures of BdBasic Protocol 3: Regular maintenance of synchronous Bd in liquid cultureAlternate Protocol 1: Regular maintenance of asynchronous Bd in liquid cultureBasic Protocol 4: Regular maintenance of synchronous Bd on solid mediumAlternate Protocol 2: Starting a culture on solid medium from a liquid cultureBasic Protocol 5: Cryopreservation of Bd
Influence of Temperature on Structural and Magnetic Properties of Gd3AlxFe5−xO12 (x = 2)
Authors: Sharma Anjori , Godara Sachin Kumar , Maji Pradip K. , Srivastava A. K. 
Published: December 2021

AbstractThis research work explores the effect of sintering temperature on morphology and magnetic properties of aluminum substituted gadolinium iron garnet Gd3AlxFe5−xO12 (x = 2). Sol–gel autocombustion method is adopted to prepare Gd3AlxFe5−xO12, and further sintered at 900, 1000, and 1100 °C. X‐ray diffraction (XRD) confirms the formation of garnet phase structure. Fourier transformation infrared ray further stands with result of XRD that reveals the presence of garnet phase. Field emission scanning microscope analysis shows the formation of average grain size 4, 6, and 13 nm for 900, 1000, and 1100 °C, respectively. Vibrating sample magnetometer results show that the coercivity decreases with increases in temperature, which indicates that this material can be used in switching devices. The calculated value of microwave operating frequency reveals that these materials can be used in ultrahigh‐frequency region.
Iron loss estimation of soft magnetic materials for power transformers considering hysteretic properties
Authors: Takeda Miho , Takahashi Yasuhito , Fujiwara Koji , Imamori Satoshi 
Published: December 2021

AbstractThis paper investigates an efficient iron loss calculation method for soft magnetic materials of power transformers. To accurately estimate iron losses in the materials such as structural steels and magnetic shielding, the magnetic field analysis taking account of the nonlinear magnetic properties is considered to be effective. In this paper, quasi‐DC magnetic properties of the soft magnetic materials are measured and the iron losses are calculated by using a three‐dimensional finite element method. Furthermore, the effect of considering hysteretic properties on the accuracy of the iron loss calculation is discussed based on a theoretical representation of eddy current loss in a conductive rectangular plate.
Prognostic impact of left atrial function in heart failure with preserved ejection fraction in sinus rhythm vs. persistent atrial fibrillation
Authors: Schönbauer Robert , Kammerlander Andreas A. , Duca Franz , Aschauer Stefan , Koschutnik Matthias , Dona Carolina , Nitsche Christian , Loewe Christian , Hengstenberg Christian , Mascherbauer Julia 
Published: December 2021

AbstractAimsWe sought to determine the prognostic impact of left atrial (LA) size and function in patients with heart failure with preserved ejection fraction (HFpEF) in sinus rhythm (SR) vs. atrial fibrillation (AF).Methods and resultsWe enrolled consecutive HFpEF patients and assessed indexed LA volumes and emptying fractions (LA‐EF) on cardiac magnetic resonance imaging. In addition, all patients underwent right and left heart catheterization, 6 min walk test, and N‐terminal prohormone of brain natriuretic peptide evaluation. We prospectively followed patients and used Cox regression models to determine the association of LA size and function with a composite endpoint of heart failure hospitalization and cardiovascular death. A total of 188 patients (71% female patients, 70 ± 8 years old) were included of whom 92 (49%) were in persistent AF. Sixty‐five patients reached the combined endpoint during a follow‐up of 31 (9–57) months. Multivariate Cox regression adjusted for established risk factors revealed that LA‐EF was significantly associated with outcome in patients in SR [adjusted hazard ratio 2.14; 95% confidence interval (1.32–3.47) per 1‐SD decline, P = 0.002]. In persistent AF, no LA imaging parameter was related to outcome. By receiver operating characteristic and restricted cubic spline analyses, we identified an LA‐EF ≥ 40% as best indicator for favourable outcomes in patients with HFpEF and SR. Persistent AF carried a similar risk for adverse outcome compared with impaired LA‐EF (<40%) in SR (log‐rank, P = 0.340).ConclusionsIn HFpEF patients in SR, impaired LA‐EF is independently associated with worse cardiovascular outcome, which is similar to persistent AF. In persistent AF, LA parameters lose their prognostic ability.
Characteristics and influence on quality of life of new‐onset pain in critical COVID‐19 survivors
Authors: Ojeda Antonio , Calvo Andrea , Cuñat Tomas , Mellado‐Artigas Ricard , Comino‐Trinidad Oscar , Aliaga Jorge , Arias Marilyn , Ferrando Carlos , Martinez‐Pallí Graciela , Dürsteler Christian 
Published: December 2021

AbstractBackgroundPain is a clinical feature of COVID‐19, however, data about persistent pain after hospital discharge, especially among ICU survivors is scarce. The aim of this study was to explore the incidence and characteristics of new‐onset pain and its impact on Health‐Related Quality of Life (HRQoL), and to quantify the presence of mood disorders in critically ill COVID‐19 survivors.MethodsThis is a preliminary report of PAIN‐COVID trial (NCT04394169) presenting a descriptive analysis in critically ill COVID‐19 survivors, following in person interview 1 month after hospital discharge. Pain was assessed using the Brief Pain Inventory, the Douleur Neuropathique 4 questionnaire and the Pain Catastrophizing Scale. HRQoL was evaluated with the EQ 5D/5L, and mood disorders with the Hospital Anxiety and Depression Scale (HADS).ResultsFrom 27 May to 19 July 2020, 203 patients were consecutively screened for eligibility, and 65 were included in this analysis. Of these, 50.8% patients reported new‐onset pain; 38.5% clinically significant pain (numerical rating score ≥3 for average pain intensity); 16.9% neuropathic pain; 4.6% pain catastrophizing thoughts, 44.6% pain in ≥2 body sites and 7.7% widespread pain. Patients with new‐onset pain had a worse EQ‐VAS and EQ index value (p < 0.001). Pain intensity was negatively correlated to both the former (Spearman ρ: −0.546, p < 0.001) and the latter (Spearman ρ: −0.387, p = 0.001). HADS anxiety and depression values equal or above eight were obtained in 10.8% and 7.7% of patients, respectively.ConclusionNew‐onset pain in critically ill COVID‐19 survivors is frequent, and it is associated with a lower HRQoL.Trial registration No.: NCT04394169. Registered 19 May 2020. https://clinicaltrials.gov/ct2/show/NCT04394169.SignificanceA substantial proportion of severe COVID‐19 survivors may develop clinically significant persistent pain, post‐intensive care syndrome and chronic ICU‐related pain. Given the number of infections worldwide and the unprecedented size of the population of critical illness survivors, providing information about the incidence of new‐onset pain, its characteristics, and its influence on the patients’ quality of life might help establish and improve pain management strategies.
Generalization of the power‐law rating curve using hydrodynamic theory and Bayesian hierarchical modeling
Authors: Hrafnkelsson Birgir , Sigurdarson Helgi , Rögnvaldsson Sölvi , Jansson Axel Örn , Vias Rafael Daníel , Gardarsson Sigurdur M. 
Published: December 2021

AbstractThe power‐law rating curve has been used extensively in hydraulic practice and hydrology. It is given by , where is discharge, is water elevation, , , and are unknown parameters. We propose a novel extension of the power‐law rating curve, referred to as the generalized power‐law rating curve. It is constructed by linking the physics of open channel flow to a model of the form . The function is referred to as the power‐law exponent and it depends on the water elevation. The proposed model and the power‐law model are fitted within the framework of Bayesian hierarchical models. By exploring the properties of the proposed rating curve and its power‐law exponent, we find that cross‐sectional shapes that are likely to be found in nature are such that the power‐law exponent will usually be in the interval . This fact is utilized for the construction of prior densities for the model parameters. An efficient Markov chain Monte Carlo sampling scheme, that utilizes the lognormal distributional assumption at the data level and Gaussian assumption at the latent level, is proposed for the two models. The two statistical models were applied to four datasets. In the case of three datasets the generalized power‐law rating curve gave a better fit than the power‐law rating curve while in the fourth case the two models fitted equally well and the generalized power‐law rating curve mimicked the power‐law rating curve. We developed an R package, bdrc, for fitting the power‐law and generalized power‐law rating curve models. It is available on CRAN.
Effect of clover sprouts protein hydrolysates as an egg substitute on physicochemical and sensory properties of mayonnaise
Authors: Mirsadeghi Darabi Dina , Ariaii Peiman , Safari Reza , Ahmadi Mohammad 
Published: December 2021

AbstractMayonnaise is a semi‐solid oil‐in‐water emulsion that in addition to eggs other stabilizers and thickeners are used as emulsifiers for better stability. Although eggs are an important ingredient in the production of mayonnaise, the health problems associated with the use of eggs is increasing due to their high cholesterol content. The aim of this study was to evaluate the feasibility of clover sprout protein hydrolysates (CSPH) to replace eggs for the production mayonnaise. First, CSPH was produced using alcalase and flavourzyme enzyme, and in order to find the best enzyme, the degree of hydrolysis (DH) and protein recovery (PR) were determined. Then four mayonnaise treatments included, T1: control (egg 9%), T2: egg 6%+ CSPH 3%, T3: egg 3%+ CSPH 6%, T4: egg 0%+ CSPH 9% was prepared and the stability, viscosity, physicochemical, textural, and sensory properties of mayonnaise was investigated. The samples containing CSPH showed that CSPH had high essential amino acids, CSPH from alcalase enzyme had higher amounts of protein, DH, PR, and increasing hydrolysis time had a positive effect on these parameters (p < .05); therefore, CSPH from alcalase enzyme was used for the production mayonnaise. The stability, viscosity, firmness, adhesion of texture, and pH increased with increasing CSPH, while the brightness, acidity, and sensory score of the samples decreased (p < .05). In general, T3 had an acceptable quality in terms of the studied characteristics, but sensory score in T4 could not be confirmed. Hence, by replacing eggs with CSPH up to 6%, mayonnaise with appropriate physicochemical and sensory properties can be produced. Therefore, the formulation egg 3%+ CSPH 6% is an appropriate choice to produce mayonnaise for consumers who are on a restricted diet to eat foods containing eggs.
Hepatotoxicity of cantharidin is associated with the altered bile acid metabolism
Authors: Cheng Weina , Wang Yazhi , Liu Jingxian , Li Xiaofei , Yu Ming , Duan Cancan , Liu Liu , Zhang Jianyong 
Published: December 2021

AbstractCantharidin (CTD) is an effective antitumor agent. However, it exhibits significant hepatotoxicity, the mechanism of which remains unclear. In this study, biochemical and histopathological analyses complemented with ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC‐MS/MS)‐based targeted metabolomic analysis of bile acids (BAs) were employed to investigate CTD‐induced hepatotoxicity in rats. Sixteen male and female Sprague–Dawley rats were randomly divided into two groups: control and CTD (1.0 mg/kg) groups. Serum and liver samples were collected after 28 days of intervention. Biochemical, histopathological, and BA metabolomic analyses were performed for all samples. Further, the key biomarkers of CTD‐induced hepatotoxicity were identified via multivariate and metabolic pathway analyses. In addition, metabolite–gene–enzyme network and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to identify the signaling pathways related to CTD‐induced hepatotoxicity. The results revealed significantly increased levels of biochemical indices (alanine aminotransferase, aspartate aminotransferase, and total bile acid). Histopathological analysis revealed that the hepatocytes were damaged. Further, 20 endogenous BAs were quantitated via UHPLC‐MS/MS, and multivariate and metabolic pathway analyses of BAs revealed that hyocholic acid, cholic acid, and chenodeoxycholic acid were the key biomarkers of CTD‐induced hepatotoxicity. Meanwhile, primary and secondary BA biosynthesis and taurine and hypotaurine metabolism were found to be associated with the mechanism by which CTD induced hepatotoxicity in rats. This study provides useful insights for research on the mechanism of CTD‐induced hepatotoxicity.
Denosumab in Cementless Total Hip Arthroplasty: Multivariate Reanalysis of 3D Femoral Stem Migration and the Influence on Outliers
Authors: Finnilä Sami , Löyttyniemi Eliisa , Aro Hannu T 
Published: December 2021

ABSTRACTIn cementless total hip arthroplasty, adequate implant stability is necessary for the success of osseointegration and rapid clinical recovery. Postoperative femoral stem migration, measured by radiostereometric analysis (RSA), defines the initial stability achieved during surgical implantation. In a recent trial of 65 postmenopausal women randomized 1:1 denosumab:placebo, denosumab failed to reduce the initial migration of a cementless femoral stem despite the successful prevention of periprosthetic bone loss. The trial applied the current RSA standard, which examined stem migration on an axis‐by‐axis basis and did not consider more complex three‐dimensional (3D) migration. Therefore, we performed a reanalysis of the trial data using a multivariate hierarchical linear mixed model (LMM). As an additional limitation, the data included influential outliers. Women with normal bone mineral density exhibited significantly (p = 0.036) less stem subsidence compared with osteopenic and osteoporotic women. Denosumab significantly decreased the variance of stem migration in osteopenic and osteoporotic women. The mean magnitude of 3D stem migration did not differ between denosumab‐treated and placebo‐treated women (p = 0.820). After application of a common statistical definition for RSA outlier identification, there were eight (12%) outliers, six in the placebo group and two in the denosumab group (p = 0.149). After exclusion of the outliers, the repeated LMM analysis demonstrated a trending difference in 3D stem migration (p = 0.086), with a significant difference of z‐axis rotation (valgus‐varus tilt) of the femoral stem (p = 0.029). The observed effect size was small and without clinically important differences in postoperative recovery. Based on a Monte Carlo simulation with random‐generated 3D migration data, multivariate LMM showed greater statistical power than univariate analyses. The application of hierarchical LMM facilitated the analysis of implant migration as a factual 3D event. The observed trend in the lower number of RSA outliers in denosumab‐treated subjects warrants powered large‐scale trials. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Impact of an evening pharmacist in a Paediatric Intensive Care Unit: a pilot study
Authors: Cree Michele L. , Singhal Nitesh , Rogan Sharna 
Published: December 2021

AbstractObjectiveTo assess the impact of an “evening” Paediatric Intensive Care Unit (PICU) pharmacist role.MethodA pilot program reviewed interventions recorded by an extended hours (until 7 pm) pharmacist in the PICU for the period 18 April until 16 June 2017. Clinical interventions documented via the in‐house pharmacy intervention records were reviewed and risk assessed by an independent multidisciplinary panel consisting of a nurse, physician, and a pharmacist. In addition, medication incidents recorded in the broader hospital clinical incident database were reviewed for the study period and also compared to an identical time period in 2016.ResultsOf 632 interventions recorded, 144 (23%) interventions were attributed to the evening pharmacist with 108 (90%) of the interventions occurring after 4:30 pm. The intervention categories consisted of 132 (92%) involving prescribing/transcribing and 12 (8%) classified under the administration and monitoring category. No pharmacist intervention was rated as major or extreme severity by any reviewer although the physician was more likely than the pharmacist or nurse to stratify interventions as minor or moderate as opposed to no risk. There was no difference in the hospital clinical incident database between the minimal harm risk medication rated incidents in 2016 compared to the same time period in 2017.ConclusionThe evening clinical pharmacist identified that 9 of 10 patients seen after 4.30 pm required an intervention, clarification, or a change in medication therapy. Future directions to improve medication safety for critically ill children should include staffing of a PICU pharmacist for extended hours on both weekdays and weekends.
Pharmacists' experiences of consumer stockpiling: insights from COVID‐19
Authors: Cameron Eliza E. , Moss Simon A. , Keitaanpaa Samuel J. , Bushell Mary‐Jessimine A. 
Published: December 2021

AbstractBackgroundConsumer stockpiling from pharmacies has been reported by media outlets throughout the course of COVID‐19.AimThis study evaluated pharmacists’ perceptions of consumer stockpiling from pharmacies, the impact of stockpiling, aggressive or hostile behaviour from customers and preparedness for COVID‐19 and future pandemics.MethodA self‐administered survey was disseminated between September and November of 2020. The survey comprised four major sections: demographic information, experiences of consumer stockpiling, impact of consumer stockpiling and preparedness for COVID‐19 and future pandemics. Survey results were analysed in Microsoft Excel using descriptive statistics.ResultsOf the 56 responses analysed, most pharmacists observed consumer stockpiling of over‐the‐counter products (98.2%), schedule 2 and schedule 3 medications (92.8%) and prescription only medications (94.6%). The most commonly stockpiled items included face masks, hand‐sanitisers and wipes, alcohol wipes and antiseptic solutions, thermometers, paracetamol and salbutamol inhalers. Patients also requested the dispensing of several months’ supply of regular prescription medications. Customer aggression was observed by 53.6% of pharmacists, with 63% of pharmacists agreeing that hostile behaviour impeded their practice. Only 36.7% of pharmacists felt adequately prepared to cope with the challenges of COVID‐19.ConclusionConsumer stockpiling from pharmacies was observed throughout COVID‐19. Stockpiling as well as aggressive and hostile behaviour from customers affected pharmacists, their staff, business and other pharmacy customers. Additional studies are needed to investigate the severity of these issues and to inform policy changes to help mitigate consumer stockpiling and prepare the pharmacy profession for future pandemics.