bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Genomic Basis of the Streptococcus Thermophilus Health-Promoting Properties
Authors: Roux Emeline , Nicolas Aurélie , Valence Florence , Siekaniec Grégoire , Chuat Victoria , Nicolas Jacques , Loir yves Le , Guédon Eric 
Published: December 2021

Abstract
BackgroundStreptococcus thermophilus is a Gram-positive bacterium widely used as starter in the dairy industry as well as in many traditional fermented products. In addition to its technological importance, it has also gained interest in recent years as beneficial bacterium due to human health-promoting functionalities. The objective of this study was to inventory the main health-promoting properties of S. thermophilus and to study their intra-species diversity at the genomic and genetic level within a collection of representative strains. ResultsIn this study various health-related functions were analyzed at the genome level from 79 genome sequences of strains isolated over a long time period from diverse products and different geographic locations. While some functions are widely conserved among isolates (e.g., degradation of lactose, and folate production) suggesting their central physiological and ecological role for the species, others including the tagatose-6-phosphate pathway involved in the catabolism of galactose, and the production of bioactive peptides and g-aminobutyric acid are strain-specific. Most of these strain-specific health-promoting properties seems to have been acquired via horizontal gene transfer events. The genetic basis for the phenotypic diversity between strains for some health related traits have also been investigated. For instance, substitutions in the galK and gadBC promoter region correlate with the ability of some strains to catabolize galactose via the Leloir pathway and to produce high level of g-aminobutyric acid, respectively. Finally, the low occurrence in S. thermophilus genomes of genes coding for biogenic amine production and antibiotic resistance is also a contributing factor to its safety status.ConclusionsThe natural intra-species diversity of S. thermophilus, therefore, represents an interesting source for innovation in the field of fermented products enriched for healthy components that can be exploited to improve human health. A better knowledge of the health-promoting properties and their genomic and genetic diversity within the species may facilitate the selection and application of strains for specific biotechnological and human health-promoting purpose. Moreover, by pointing out that a substantial part of its functional potential still defies us, our work opens the way to uncover additional health-related functions through the intra-species diversity exploration of S. thermophilus by comparative genomics approaches.
Assessing Rectocele Depth and Its Association with Symptoms of Pelvic Floor Disorders Using Transperineal Ultrasound
Authors: Jeong Hongyoon , Park Duk Hoon , Won Daeyoun , Lee Jong Kyun 
Published: December 2021

Abstract
Aim
We investigated the clinical features of symptomatic rectoceles, as measured by transperineal ultrasound (TPUS), and evaluated the association between rectocele size and the clinical symptoms of pelvic floor disorders.
Method
This was a retrospective study using data obtained at a pelvic floor centre between August 2020 and January 2021. A total of 125 patients with defaecation disorders, such as constipation and faecal incontinence, were included. The preoperative questionnaire included the Cleveland Clinic Constipation Scoring System (CCCS, Wexner constipation score), Cleveland Clinic Incontinence Score (CCIS, Wexner incontinence score), faecal incontinence severity index (FISI), and faecal incontinence quality of life (FIQOL) scale. The size of the rectocele was measured on the trans-perineal 2D images. Patients were assigned to three groups based on rectocele size: no rectocele (<10 mm), ≥10 mm rectocele, and ≥15 mm rectocele.
Results
In the study population, 43 participants (34.4%) had no rectocele, 50 (40.0%) had ≥10 mm rectocele, and 32 (25.6%) had ≥15 mm rectocele. From the no rectocele to ≥15 mm rectocele group, the scores for the symptoms of incontinence and constipation increased, and the quality of life worsened. The CCIS (6.00±4.95 vs 8.62±5.77 vs 11.08±5.63, P = 0.004), FIQOL (13.72±4.19 vs 13.42±4.35 vs 10.38±3.88, P = 0.006), FISI (18.83±17.67 vs 25.15±17.34 vs 33.42±15.49, P = 0.010), and CCCS (7.50±6.26 vs 8.65±5.31 vs 13.11±5.90, P = 0.006), respectively.
Conclusion
The TPUS was a valuable method for the anatomical evaluation of symptomatic rectocele. The larger the size of the symptomatic rectocele measured using TPUS, the more severe the clinical symptoms.
A Joint Optimization Framework Integrated with Biological Knowledge for Clustering Incomplete Gene Expression Data
Authors: Li Dan , Gu Hong , Chang Qiaozhen , Wang Jia , Qin Pan 
Published: December 2021

Abstract
Clustering algorithms have been successfully applied to identify co-expressed gene groups from gene expression data. Missing values often occur in gene expression data, which presents a challenge for gene clustering. When partitioning incomplete gene expression data into co-expressed gene groups, missing value imputation and clustering are generally performed as two separate processes. These two-stage methods are likely to result in unsuitable imputation values for clustering task and unsatisfying clustering performance. This paper proposes a multi-objective joint optimization framework for clustering incomplete gene expression data that addresses this problem. The proposed framework can impute the missing expression values under the guidance of clustering, and therefore realize the synergistic improvement of imputation and clustering. In addition, gene expression similarity and gene semantic similarity extracted from the Gene Ontology are combined, as the form of functional neighbor interval for each missing expression value, to provide reasonable constraints for the joint optimization framework. Experiments on several benchmark data sets confirm the effectiveness of the proposed framework.
Elution profile of cationic and anionic adsorbate from exhausted adsorbent using solvent desorption
Authors: Patel Himanshu 
Published: December 2021

Abstract
Present invention involves to study the elution profile of anionic and cationic compounds from exhausted adsorbents using various eluents. Batch elution studies of anionic components like Congo Red dye and Carbonate ion; and cationic compounds such as Methylene blue dye and Cadmium metal from previously used naturally prepared adsorbents i.e. Gulmohar (Delonix regia) leaf powder - GLP; and Neem (Azadirachta indica) leaf powder – NLP and their derivatives were conducted. Different eluents used for batch study were various acids and alkaline solution having various concentration and solvents having different functional groups in seven sorption-desorption cycles. The batch data were accessed by kinetic models (Pseudo First-, Pseudo Second-order, Intra-partice and Elovic equation). Column elution experiments of Congo red and Cadmium from NLP and activated charcoal from NLP (AC-NLP) respectively was performed using selected eluent. Sorption and elution process plots and parameters for seven sorption–desorption cycles were evaluated and discussed. Plots of life cycle indicating activity-indicator equations were drawn, and their parameters were calculated and mentioned. From desorption efficiencies, it revealed that desorption exploration is predominately depends upon pH factor.
Excessive Positive Fluid Balance Has A Negative Effect On Short-Term Renal Outcomes After Kidney Transplantation
Authors: Gwon Jun Gyo , Jung Cheol Woong , Lee Chang Hun , Kim Myung-Gyu 
Published: December 2021

Abstract
Background: Optimized postoperative fluid management is important for maintaining early allograft function after kidney transplantation (KT). However, there is still no clear guidance regarding fluid treatment after KT. In this study, we investigated the effect of perioperative fluid balance on postoperative allograft function.Methods: Recipients who underwent KT between March 2012 and August 2018 were included, and their medical records were reviewed retrospectively. We calculated fluid balance, which is the difference between total input and output during the 3 days after KT, and analyzed the change in estimated glomerular filtration rate (eGFR) according to fluid balance.Results: A total of 178 patients were included after excluding those with delayed graft function or urine output <2000 ml on the first day after KT. Among them, 116 received kidneys from living donors and 62 received kidneys from deceased donors. The total fluid balance up to day 3 was 4,236.9 ± 2830.4 ml. Old age, high body mass index (BMI), excessive positive fluid balance of the recipient, and high final creatinine of the donor were significantly associated with low eGFR at 1 week. In addition, old age, BMI, and fluid balance of the recipient predicted the 1-month eGFR. In multivariate analysis, an excessive positive fluid balance was an independent predictor of low 1-week eGFR (p=0.031). Conclusions: This study demonstrated that excessive positive fluid balance can negatively affect early graft function after KT. Proper fluid management strategies based on volume conditions may provide important therapeutic opportunities to improve early renal outcomes after KT.
Resilience among undergraduate nursing students: Findings of the first cross-sectional study in Palestine
Authors: Alkaissi A , Said N.B , Qadous Sh , AlMahmoud O , AlKony M 
Published: December 2021

Abstract
Background
Resilience has emerged as a concept that could explain and predict good academic and well-being of students in stressful and traumatic situations. This study was conducted to assess resilience and identify predictors of high resilience scores among nursing students in Palestine.
Methods
This cross-sectional study adhered to the Strengthening the Reporting of Observational Studies in Epidemiology statement. Undergraduate nursing students in all academic years were recruited and asked to complete a questionnaire the contained the trait and state resilience scales.
Results
In this study, 290 students completed the questionnaire (response rate = 92.4%). The mean combined resilience score was 134.1 (SD: 12.8). Higher combined resilience scores were predicted by being in first academic year (p-value < 0.003), living in Israeli seized areas (p-value < 0.044), absence of chronic diseases (p-value = 0.035), experiencing addiction issues (p-value = 0.031), living in a house with enough number of rooms per siblings (p-value = 0.015), and having a study routine on daily basis (p-value < 0.001).
Conclusions
Undergraduate nursing students in Palestine reported relatively high trait and state resilience. Higher resilience scores were predicted by favorable living and study conditions. More studies are still needed to investigate the relationship between resilience scores, perceived well-being, willingness to care, and future success of nursing students in Palestine.
C-Reactive Protein Levels in Patients with Infectious Mononucleosis
Authors: Nevet Alon , Shapira Maanit 
Published: December 2021

Abstract
Background: Plasma level of C-reactive protein (CRP) is used as a biomarker of systemic inflammation. Differential distributions of CRP levels related to different pathogens aid clinicians in the differential diagnosis of patients.Objectives: To evaluate the distribution of CRP levels in patients with Infectious Mononucleosis (IMN) and its correlation with different pathogen and host characteristics.Methods: A retrospective study conducted on electronic medical records of patients diagnosed clinically and serologically with IMN in a public regional hospital during consecutive five years.Results: CRP levels were significantly elevated in patients hospitalized with clinical diagnosis of IMN and serologic evidence of EBV (average 6.8 md/dL) or CMV (average 6.3 md/dL). However, levels of CRP were not significantly correlated with plasma levels of liver enzymes. Conclusions: Although CRP levels may aid in the differential diagnosis of respiratory syndromes, its distribution in patients infected by hepatotrophic viruses is similar to that in bacterial infections.
HMMR Potential as a Diagnostic and Prognostic Biomarker of Cancer - Speculation Based on a Pan-cancer Analysis
Authors: Shang junyi , Qi Yong 
Published: December 2021

Abstract
BackgroundAlthough the status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is still unknown, HMMR has been found to be upregulated and associated with poor prognosis for some tumors. The aims of our study included: exploring HMMR expression in different tumor types using The Cancer Genome Atlas (TCGA) or other public databases for a pan-cancer analysis, exploring the relationship between HMMR and tumor prognosis, and exploring the role of HMMR in tumor immunity. MethodsWe evaluated HMMR expression in pan-cancer and in different tumor cells using the TCGA, TIMER, ONCOMINE, and CCLE databases. Next, we analyzed the relationship between HMMR and the prognosis of different tumors subtypes. Receiver Operating Characteristic (ROC) curves were constructed based on the expression of HMMR, and analyzed using a correlation between HMMR and pathological stage and tumor immunity in pan-cancer. In the final step, we analyzed protein-protein interactions using STRING and implemented a GO/KEGG enrichment analysis.ResultsNo matter the pairing or unpairing of data, HMMR expression generally increased as compared to corresponding normal tissue. Based on a CCLE study, our results indicated that HMMR is widely expressed in a variety of tumor cells. For most tumor types, high HMMR expression was associated with reduced Overall Survival (OS), Return to Functional Status (RFS), and Platinum Free Interval (PFI). ROC curves indicated that HMMR displays a high degree of prediction potential for most tumor types. In pan-cancer, HMMR is correlated with some clinical staging, immune cells, and immune checkpoints for some tumors. The results of the GO/KEGG enrichment analysis for proteins most closely related to HMMR, indicating that the most highly enriched pathways are all related to tumor development.ConclusionOur pan-cancer analysis of HMMR suggests that HMMR can be used as a potential diagnostic and prognostic indicator of pan-cancer and that HMMR may be involved in tumor development.
Investigation of the Effect of Vibration Characteristics on the Grinding Performance of Aero-Engine Blade Tip
Authors: Li Wei , Chen Qidi , Wu Jian , Liu Mingjia , Ren Yinghui , Ibrahim Ahmed Mohamed Mahmoud 
Published: December 2021

Abstract
The machining quality of the blade tip has a great influence on the service performance and life of the aero-engine blade. The recent paper investigates the effect of vibration during the grinding process of the GH4169 nickel-based superalloy blade tip. Moreover, this paper proposes a theoretical model to link the unbalance of the grinding wheel, the vibration, and the surface topography characteristics of the blade. The results show that the blade vibration during grinding and the resulting non-linear change of the grinding depth could reduce the surface quality of the blade tip, and lead to differences in the surface quality of the blade tip in different areas, where the surface roughness in the entry area zone I is the largest, in the exit area zone III is the second largest, and the intermediate area zone III is the smallest. Grinding depth has a greater impact on the difference of the surface quality in the blade tip grinding process, especially when the grinding depth is greater than 4 μm, the difference of surface roughness increases significantly. On the other hand, the feed rate has little effect on the difference in surface quality. Adding damping block can reduce the surface roughness of the blade tip, however, it does not reduce the difference in surface quality.
Evaluating Diagnostic Accuracy and Determining Optimal Diagnostic Thresholds of Three Different Approaches to [68Ga]-DOTATATE PET/MRI Analysis in Patients with Meningioma
Authors: Kim Sean , Roytman Michelle , Madera Gabriela , Magge Rajiv , Liechty Benjamin , Ramakrishna Rohan , Pannullo Susan , Schwartz Theodore , Karakatsanis Nicolas , Osborne Joseph , Lin Eaton , Knisely Jonathan , Ivanidze Jana 
Published: December 2021

Abstract
PURPOSEMultiple approaches with [Ga68]-DOTATATE, a somatostatin analog PET radiotracer, have demonstrated clinical utility in evaluation of meningioma but have not been compared directly. Our purpose was to compare diagnostic performance of three approaches to quantitative brain [68Ga]-DOTATATE PET/MRI analysis in patients with suspected meningioma recurrence and to establish the optimal diagnostic threshold for each method.METHODSPatients with suspected meningioma were imaged prospectively with [68Ga]-DOTATATE brain PET/MRI. Lesions were classified as meningiomas and post-treatment change (PTC), based on pathology findings and follow up MRI appearance. Lesions were reclassified using the following methods: absolute SUV threshold (SUV), SUV ratio (SUVR) to superior sagittal sinus (SSS) (SUVRsss), and SUVR to the pituitary gland (SUVRpit). Diagnostic performance of the three methods was compared using contingency tables and McNemar’s test. Previously published pre-determined thresholds were assessed where applicable. The optimal thresholds for each method were identified using Youden’s J statistics.RESULTS166 meningiomas and 41 PTC lesions were identified across 62 patients. SUV, SUVRsss, and SUVRpit of meningioma were significantly higher than those of PTC (P<0.0001). The optimal thresholds for SUV, SUVRsss, and SUVRpit were 4.65, 3.23, and 0.260, respectively. At the optimal thresholds, SUV had the highest specificity (97.6%) and SUVRsss had the highest sensitivity (86.1%). An ROC analysis of SUV, SUVRsss, and SUVRpit revealed AUC of 0.932, 0.910, and 0.915, respectively (P<0.0001).CONCLUSIONWe found that the SUVRsss method may have the most robust combination of sensitivity and specificity in the diagnosis of meningioma in the post-treatment setting, with the optimal threshold of 3.23. Future studies validating our findings in different patient populations are needed to continue optimizing the diagnostic performance of [68Ga]-DOTATATE PET/MRI in meningioma patients. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT04081701. Registered 9 September 2019. https://clinicaltrials.gov/ct2/show/NCT04081701
Bonding Integrity of Hybrid 18Ni300-17-4 PH Steel Using The Laser Powder Bed Fusion Process For The Fabrication of Plastic Injection Mould Inserts
Authors: Chan Yuk Lun Simon , Diegel Olaf , Xu Xun 
Published: December 2021

Abstract
Laser powder bed fusion (LPBF) is a metal additive manufacturing (AM) process for fabricating high-performance functional parts and tools in various metallic alloys, such as titanium, aluminium and tool steels. The process can produce geometrically complex features such as conformal cooling channels (CCC) in plastic injection mould inserts to improve cooling efficiency. A recent attempt using a hybrid-build LPBF AM technique to fabricate aluminium mould inserts with CCC attained a substantial reduction in processing time, making it an attractive alternative method to the mould-making industry. Also, the successful bonding of aluminium powder with wrought aluminium alloys proved the practicability of this concept. This study further investigates whether a similarly successful outcome could apply to tool steel since tool steel is the preferred material for constructing high-grade high-volume plastic injection moulds. In this investigation, hybrid 18Ni300 powder-wrought 17-4 PH steel parts were additively fabricated using the hybrid-build LPBF technique, followed by various post-build heat treatments. The mechanical and metallurgical properties of the samples’ bonded interface were examined. Microstructure analysis revealed homogenous powder-substrate fusion across the interface region. Results from tensile tests confirmed strong powder-substrate bonding as none of the tensile fractures occurred at the interface. A direct post-build one-hour age-hardening treatment achieved the best combination of hardness, tensile strength, and ductility. The overall result demonstrates that hybrid-built 18Ni300-17-4 PH steel can be a material choice for manufacturing durable and high-performance injection mould inserts for high-volume production.
Perception Regarding Live Kidney Donation in the General Population of South Korea
Authors: Kang Eunjeong , Lee Jangwook , Park Sehoon , Kim Yaerim , Kim Hyo Jeong , Kim Yong Chul , Kim Dong Ki , Joo Kwon Wook , Kim Yon Su , Choi Insun , Lee Hajeong 
Published: December 2021

Abstract
Background: It is necessary to know how the general population recognizes live kidney donation in Korea, where living donor kidney transplantations (KT) are the mainstream.Methods: Participants were randomly selected from the general population after proportional allocation by region, sex, and age. Selected participants received a questionnaire that included demographic information, socioeconomic and marital statuses, prior recognition of live donor KT, expected changes after donation, and the need for support after donor nephrectomy.Results: In total, 1,000 participants responded to the web-based survey. After reading the detailed explanation, 83.8% of the respondents answered that they fully understood living donor KT. Among the participants, 811(81.1%) answered that they knew about living donor KT, and 51.1% were willing to donate. Various complications after nephrectomy (54.4%) and deterioration in health after donation (69.1%) were the most important reasons for those who were reluctant to donate, and the possibility of a decrease in economic activities after donation accounted for 33.8%. Overall, 73.2% were more likely to agree that the government should provide social and economic support to living kidney donors; this number increased to 81.3% after exposure to the description of donor nephrectomy (P<0.001). Financial support, including surgery (74.2%) and regular medical check-up costs (70.1%), was the most preferred government support.Conclusions: The Korean general population seemed to be aware of the value and safety of kidney donation, although only half of them were willing to donate due to concerns about possible complications. Most participants agreed on social and economic support for living kidney donors, especially for surgery-related costs.