bluuebunny/crossref_metadata_2025_split huggingface dataset:
A numerical range characterization of unitary matrices over a finite field
Authors: Ballico E. 
Published: April 2021

Let [Formula: see text] be a prime power, [Formula: see text], and let [Formula: see text] be an [Formula: see text] matrix over [Formula: see text]. We prove that the numerical range of [Formula: see text] and [Formula: see text] is the same for every rank [Formula: see text] matrix [Formula: see text] if and only if [Formula: see text] is a multiple of a unitary matrix. The corresponding result for complex matrices was proved by Chien, Gau, Li, Tsai and Wang [Products of operators and numerical range, Linear Multilinear Algebra 64(1) (2016) 58–67].
Use of α-Lactalbumin and Caseinoglycomacropeptide as Biopeptide Precursors and as Functional Additives in Milk Beverages Fermented by L. helveticus
Authors: Skrzypczak Katarzyna , Fornal Emilia , Domagała Dorota , Gustaw Waldemar , Jabłońska-Ryś Ewa , Sławińska Aneta , Radzki Wojciech , Kononiuk Anna , Waśko Adam 
Published: April 2021

The objective of this investigation was to verify whether biologically active peptides (BAPs) could be obtained from water solutions of α-lactalbumin (α-la) and caseinoglycomacropeptide (CGMP) through an application of the new Lactobacillus helveticus strains. Also, the aim of this research was to determine the influence of addition of the analyzed protein preparations to milk subjected to fermentation by tested bacterial strains on the physicochemical properties of obtained milk beverages. The results indicate that CGMP is a more preferable source for the production of BAPs by the test bacteria than α-la. The antihypertensive and ACE inhibitory effects were the most widespread bioactivities among the detected BAPs. α-la containing fermented milk beverages had higher values of springiness, gumminess, chewiness, and resilience than analogous products containing CGMP, while CGMP-supplemented fermented products exhibited higher values of the hardness parameter. The highest values of hardness (

0.416
±
0.05

N) were recorded for beverages fermented by DSMZ containing the addition of CGMP, while the lowest value of this parameter (

0.186
±
0.06

N) was noted for products containing α-la and fermented by B734. Moreover, CGMP-containing fermented products were characterized by a generally higher value of the proteolysis index (PI) than analogous variants containing α-la. The use of analyzed strains and the selected protein preparations has a positive effect on the texture of fermented milk beverages and might contribute to an increase in the health-promoting potential of such products.
Inhibition of the FACT Complex Targets Aberrant Hedgehog Signaling and Overcomes Resistance to Smoothened Antagonists
Authors: Mo Jialin , Liu Fang , Sun Xi , Huang Hongting , Tan Kezhe , Zhao Xiaojing , Li Rui , Jiang Wenyan , Sui Yi , Chen Xiaosong , Shen Kunwei , Zhang Liye , Ma Jie , Zhao Kewen , Tang Yujie 
Published: April 2021

Abstract

Hedgehog signaling is aberrantly activated in hematologic malignancies and solid tumors, and targeting it is a promising therapeutic strategy against these cancers. Resistance to clinically available hedgehog-targeted Smoothened inhibitor (SMOi) drugs has become a critical issue in hedgehog-driven cancer treatment. Our previous studies identified inhibition of BET and CDK7 as two epigenetic/transcriptional-targeted therapeutic strategies for overcoming SMOi resistance, providing a promising direction for anti-hedgehog drug development. To uncover additional strategies for inhibiting aberrant hedgehog activity, here we performed CRISPR-Cas9 screening with an single-guide RNA library targeting epigenetic and transcriptional modulators in hedgehog-driven medulloblastoma cells, combined with tumor dataset analyses. Structure specific recognition protein 1 (SSRP1), a subunit of facilitates chromatin transcription (FACT) complex, was identified as a hedgehog-induced essential oncogene and therapeutic target in hedgehog-driven cancer. The FACT inhibitor CBL0137, which has entered clinical trials for cancer, effectively suppressed in vitro and in vivo growth of multiple SMOi-responsive and SMOi-resistant hedgehog-driven cancer models. Mechanistically, CBL0137 exerted anti-hedgehog activity by targeting transcription of GLI1 and GLI2, which are core transcription factors of the hedgehog pathway. SSRP1 bound the promoter regions of GLI1 and GLI2, while CBL0137 treatment substantially disrupted these interactions. Moreover, CBL0137 synergized with BET or CDK7 inhibitors to antagonize aberrant hedgehog pathway and growth of hedgehog-driven cancer models. Taken together, these results identify FACT inhibition as a promising epigenetic/transcriptional-targeted therapeutic strategy for treating hedgehog-driven cancers and overcoming SMOi resistance.

Significance:
This study identifies FACT inhibition as an anti-hedgehog therapeutic strategy for overcoming resistance to Smoothened inhibitors and provides preclinical support for initiating clinical trials of FACT-targeted drug CBL0137 against hedgehog-driven cancers.
Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer
Authors: Chang Antao , Liu Liang , Ashby Justin M. , Wu Dan , Chen Yanan , O'Neill Stacey S. , Huang Shan , Wang Juan , Wang Guanwen , Cheng Dongmei , Tan Xiaoming , Petty W.J. , Pasche Boris C. , Xiang Rong , Zhang Wei , Sun Peiqing 
Published: April 2021

AbstractWhen recruited to promoters, histone 3 lysine 4 (H3K4) methyltransferases KMT2 (KMT2A-D) activate transcription by opening chromatin through H3K4 methylation. Here, we report that KMT2 mutations occur frequently in non–small cell lung cancer (NSCLC) and are associated with high mutation loads and poor survival. KMT2C regulated DNA damage responses (DDR) through direct recruitment to DNA damage sites by Ago2 and small noncoding DNA damage response RNA, where it mediates H3K4 methylation, chromatin relaxation, secondary recruitment of DDR factors, and amplification of DDR signals along chromatin. Furthermore, by disrupting homologous recombination (HR)–mediated DNA repair, KMT2C/D mutations sensitized NSCLC to Poly(ADP-ribose) polymerase inhibitors (PARPi), whose efficacy is unclear in NSCLC due to low BRCA1/2 mutation rates. These results demonstrate a novel, transcription-independent role of KMT2C in DDR and identify high-frequency KMT2C/D mutations as much-needed biomarkers for PARPi therapies in NSCLC and other cancers with infrequent BRCA1/2 mutations.Significance:This study uncovers a critical role for KMT2C in DDR via direct recruitment to DNA damage sites, identifying high-frequency KMT2C/D mutations as biomarkers for response to PARP inhibition in cancer.
Molecular Subtypes of Pancreatic Cancer: A Proteomics Approach
Authors: Thakur Ravi , Singh Pankaj K. 
Published: April 2021

Abstract
Through molecular subtyping, therapeutic vulnerabilities can be exploited for developing personalized medicine. The real utility of molecular subtyping lies in the clinical translation for disease characterization. Proteomic methods with defined marker sets hold great promise for improving therapy outcomes by improving the speed of predictions for devising treatment strategies.
See related article by Son et al., p. 3370
Interleukin-4 Receptor Inhibition Targeting Metastasis Independent of Macrophages
Authors: Cleary Megan M. , Bharathy Narendra , Abraham Jinu , Kim Jin-Ah , Rudzinski Erin R. , Michalek Joel E. , Keller Charles 
Published: April 2021

Abstract
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma occurring in children and carries a dismal prognosis when metastatic disease is detected. Our previous work has suggested the cytokine receptor IL4Rα may play a role in contributing to metastasis in the alveolar subtype of rhabdomyosarcoma (aRMS), and thus could present a therapeutic target. The IL4 signaling axis has been characterized in various adult cancers as well; however, pediatric trials often follow similar adult trials and the role of the IL4Rα receptor has not been explored in the context of a mediator of metastasis in adult disease. Here, we demonstrate that the impact of IL4Rα blockade in an orthotopic allograft model of aRMS is not mediated by a macrophage response. We further examine the effect of IL4 blockade in adult colon, breast, and prostate cancers and find that inhibition of IL4Rα signaling modulates in vitro cell viability of HCT-116 colon carcinoma cells; however, this finding did not translate to an autocrine-related in vivo difference in tumor burden or lung metastasis. Our results suggest that if humanized IL4 mouse host strains are not available (or not ideal due to the need for immunosuppressing the host innate immune response for xenograft systems), then genetically-engineered mice and mouse allograft studies may be the best indicator of therapeutic targeting efficacy.
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes
Authors: Mesirca Pietro , Nakao Shu , Nissen Sarah Dalgas , Forte Gabriella , Anderson Cali , Trussell Tariq , Li Jue , Cox Charlotte , Zi Min , Logantha Sunil , Yaar Sana , Cartensen Helena , Bidaud Isabelle , Stuart Luke , Soattin Luca , Morris Gwilym M. , da Costa Martins Paula A. , Cartwright Elizabeth J. , Oceandy Delvac , Mangoni Matteo E. , Jespersen Thomas , Buhl Rikke , Dobrzynski Halina , Boyett Mark R. , D’Souza Alicia 
Published: April 2021

Rationale:
Athletes present with atrioventricular node dysfunction manifesting as atrioventricular block. This can necessitate electronic pacemaker implantation, known to be more frequent in athletes with a long training history.

Objective:
Atrioventricular block in athletes is attributed to high vagal tone. Here, we investigated the alternative hypothesis that electrical remodeling of the atrioventricular node is responsible.

Methods and Results:

Radiotelemetry ECG data and atrioventricular node biopsies were collected in sedentary and trained Standardbred racehorses, a large-animal model of the athlete’s heart. Trained horses presented with longer PR intervals (that persisted under complete autonomic block) versus sedentary horses, concomitant with reduced expression of key ion channels involved in atrioventricular node conduction: L-type Ca
2+
channel subunit Ca
V
1.2 and HCN4 (hyperpolarization-activated cyclic nucleotide-gated channel 4). Atrioventricular node electrophysiology was explored further in mice; prolongation of the PR interval (in vivo and ex vivo), Wenckebach cycle length, and atrioventricular node refractory period were observed in mice trained by swimming versus sedentary mice. Transcriptional profiling in laser-capture microdissected atrioventricular node revealed striking reduction in pacemaking ion channels in trained mice, translating into protein downregulation of Ca
V
1.2 and HCN4. Correspondingly, patch-clamp recordings in isolated atrioventricular node myocytes demonstrated a training-induced reduction in
I

Ca,
L

and
I
f
density that likely contributed to the observed lower frequency of action potential firing in trained cohorts. MicroRNA (miR) profiling and in vitro studies revealed miR-211-5p and miR-432 as direct regulators of Ca
V
1.2 and HCN4. In vivo miRs suppression or detraining restored training-induced PR prolongation and ion channel remodeling.

Conclusions:
Training-induced atrioventricular node dysfunction is underscored by likely miR-mediated transcriptional remodeling that translates into reduced current density of key ionic currents involved in impulse generation and conduction. We conclude that electrical remodeling is a key mechanism underlying atrioventricular block in athletes.
On Yang Xingmi’s Bloc—With an Emphasis on Socio-political Setting, Subjugation, and Subordination
Authors: Ng Pak-sheung 
Published: April 2021

Abstract
The disintegration of Tang central authority and the resultant spawning of local strongmen (tuhao 土豪) shaped the socio-political nature of Yang Xingmi’s 楊行密 (852–905) bloc. Generally speaking, blocs founded by tuhao had generally been characterized by provincialism, but Yang Xingmi managed to avoid excessive reliance on a particular geographical origin. How to handle the challenges posed by recalcitrant meritorious officials was also of major concern to Yang Xingmi, and later Xu Wen 徐溫 (862–927), in the process of consolidating their authority. Thanks to a strong central army, rebellions initiated by ambitious meritorious officials were suppressed. In addition to finding methods for subjugating Yang’s recalcitrant meritorious officials, Xu Wen needed to address challenges posed by local strongmen; this article serves as a case study on the methodology of using genealogical records to examine the dynamics instrumental in shaping local history.
The Prefatory Self: Images of the Author in Traditional Chinese Drama
Authors: Wang Guojun 
Published: April 2021

Abstract
This article considers representations of Chinese opera authors in the prefatory space of their theatrical works. Despite the longstanding tradition of portraiture and drama production in premodern China, existing materials suggest that pictorial depictions of the authors started to appear in play scripts primarily during the Qing dynasty. How are those images related to theatrical works and their authors? Instead of treating authorship as a type of ownership, this article studies the multifaceted nature of authorial images by examining the depiction of the authors’ hairstyles and clothing alongside other content in the front matter of those plays. Situating the phenomenon within the histories of Chinese drama, clothing, and book culture, this article argues that authors increasingly appeared in late imperial Chinese drama in their social roles, moving from the prefatory space to the drama script proper.
Une mise en scène cartographique de la mission
Authors: Vasquez Jean-Michel 
Published: April 2021

Résumé
En 1885, le périodique des Missions Catholiques se lance dans la réalisation de grandes cartes à partir des travaux de missionnaires et portant sur l’ avancée de l’ évangélisation sur tous les continents. “Pour suivre la marche et les progrès de la civilisation”, chaque année jusqu’ en 1915, une carte sera publiée et offerte aux souscripteurs. Ensemble, la trentaine de cartes compose un corpus inégalé sur la représentation des missions catholiques. Simple décoration ou véritable outil de propagande, ces cartes destinées à être affichées et exposées méritent une analyse de leur forme comme de leur contenu. A l’ aide d’ exemples originaux, il s’ agira de montrer quels avantages détient le support cartographique dans un objectif de communication et de mesurer la place qu’ occupent les cartes affichées dans la société française de l’ époque.
Les dioramas
Authors: Girard Max 
Published: April 2021

Résumé
Le but de cet article est d’ étudier l’ utilisation des dioramas missionnaires à l’ exposition coloniale de Paris en 1931. Les dioramas y deviennent les vecteurs les plus utilisés par les missionnaires catholiques pour représenter le contact avec les populations colonisées et leur rôle dans la « mission civilisatrice ». Les différents types de dioramas qui expriment une vision paternaliste des « Autres » sont de moins en moins utilisés à partir de l’ exposition de 1937, car les organisateurs leur préfèrent des vecteurs plus dynamiques comme le cinéma ou les congrès qui montrent l’ universalité et le dynamisme de l’ Eglise.
<strong>A new species of <em>Echidnodella</em> (Asterinales, Lembosiaceae) from Western Ghats of Kerala State, India </strong>
Authors: MOHAMED HINA , THOMAS JACOB 
Published: April 2021

Black mildews belong to a wide range of leaf inhabiting fungal genera, which causes severe damage to the living leaves, affect photosynthetic efficiency, cause physiological imbalances, and reduces the plants’ aesthetic value. During a survey of foliicolous fungi in Vagamon hills of Kerala state’s Western Ghats region, an endemic medicinal plant Xanthophyllum arnottianum was found infected with an undescribed species of black mildew causing fungal genus Echidnodella. Their mycelia are non-appressoriate and devoid of hypostroma. Thyriothecia are oval, ellipsoidal, X or Y shaped, elongated producing eight uniseptate brown coloured ascospores in each bitunicate asci. Echidnodella was distinguished from the allied genus Echidnodes in the absence of paraphyses and from the genera Lembosia and Morenoella in the lack of appressoria (haustoria). This new species, Echidnodella vagamonensis is described and illustrated in detail to provide the consolidated account of the species known on this host genus.
Monitoring patients with head and neck cancer for flu-like symptoms during the COVID-19 pandemic
Authors: Cavalieri Stefano , Colombo Elena , Bottiglieri Achille , Massa Giacomo , Platini Francesca , Ottini Arianna , Filippini Daria Maria , Zattarin Emma , Bergamini Cristiana , Resteghini Carlo , Alfieri Salvatore , Di Martino Vito , Tiraferri Valentina , Locati Laura Deborah , Licitra Lisa 
Published: April 2021

Objective: To capture and monitor flu-like symptoms in relation to the clinical characteristics and the oncologic treatment of a large head and neck cancer (HNC) patient cohort during the Coronavirus disease 2019 (COVID-19) pandemic. Methods: Patients were monitored through by 2 rounds of interviews. Clinical characteristics of patients with no symptoms (group 0) and of those reporting ⩾1 (group A), ⩾3 (group B), or ⩾5 symptoms (group C) were analyzed. Patients with ⩾1 symptom at both interviews were defined as group A2. Results: Five hundred patients with HNC were analyzed. A higher frequency of patients with the following characteristics was observed in group A vs group 0: active treatment (40% vs 24%, p = 0.0002), gastrostomy (6% vs 2%, p = 0.027), recent active treatment (48% vs 29%, p < 0.0001), and higher number of concomitant medications ( p = 0.01). A lower median age was observed in group B vs group no-B (patients with fewer than three symptoms) (59 vs 63.55 years, p = 0.016) and in group A2 vs group no-A2 (patients without at least one symptom at both interviews) (56 vs 63 years, p = 0.021); patients in group B received more recent active treatment than those in group no-B and in group A2 vs those in group no-A2 ( p = 0.024 and 0.043, respectively); patients in group B had a lower body mass index than those in group no-B (22.4 vs 23.93 kg/m2, p = 0.0066). Conclusions: This work is based on patient-reported symptoms and signs independently of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. In the future, these results might serve as a a benchmark for clinicians triaging and managing patients with HNC during infectious outbreaks involving flu-like symptoms.
Gardner-associated fibroma of the neck: role of a multidisciplinary evaluation for familial adenomatous polyposis diagnosis
Authors: Signoroni Stefano , Piozzi Guglielmo Niccolò , Collini Paola , Cocco Ivana Maria Francesca , Biasoni Davide , Chiaravalli Stefano , Ricci Maria Teresa , Vitellaro Marco 
Published: April 2021

Introduction: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant disorder characterized by the development of multiple adenomas in the colon and rectum with a lifetime risk of 80%–100% to develop colorectal cancer if undetected or untreated. Gardner-associated fibroma (GAF) is a rare, benign soft tissue lesion with uncertain pathogenesis. GAF is generally associated with FAP in its clinical variant, called Gardner syndrome (GS). Case Description: A 16-year-old boy with no comorbidities and no significant medical history was referred to the Unit of Hereditary Digestive Tract Tumours, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, for genetic counselling after surgical removal of a right anterior cervical paramedian fibroma. The histopathology on the specimen led to the diagnosis of GAF. He had no family history for colorectal cancer or gastrointestinal polyposis and denied any gastrointestinal symptoms. Physical examination showed a small frontal osteoma and colonoscopy showed the presence of multiple small sessile polyps (>100 polyps, diameter <5 mm) diffusely present on the large bowel. Genetic testing revealed a pathogenic germline variant in the APC gene. The predictive genetic test on the patient’s parents and sister was negative for the identified APC mutation; therefore, the patient carried an apparent de novo germline mutation. Conclusions: GAF may represent a sentinel sign of FAP, preceding gastrointestinal symptoms and endoscopic findings. A careful multidisciplinary approach is determinant for correct and early diagnosis of FAP.
Attention-Deficit/Hyperactivity Disorder, networks and introjection
Authors: Forrest Alasdair 
Published: April 2021

Group analysts have not much turned their attention to Attention-Deficit/Hyperactivity Disorder. There is only one paragraph on it in this journal—and in fact it was in the newsletter accompanying it (Leal, 2013)—alongside a few incidental references. In part, this may reflect a general distrust of diagnostic labels, particularly those relating to disturbed development, defined medically. It may also reflect the recent lack of attention towards group-analytic formulations of specific psychopathological constructs. Instead, group-analytic writers have recently been particularly interested in the social unconscious and a more detailed analysis of issues of power and positionality. While this is necessary, and no analysis of people social to their core is competent without it, there is also space for a detailed consideration of psychopathology. To advance this, I attempt a group-analytic understanding of the concept of ADHD. I do this because I shall argue it is a clear example of the balance between projection and introjection, and that an adequate analysis of disturbance in a network must account for both sets of processes. I shall also do it to illustrate that such a group-analytic formulation should be possible, and to encourage further group-analytic formulations of other specific psychopathological constructs. Initially, I shall describe the development and utility of the concept, tying it to neurobiological findings, particularly those related to the Default Mode Network. Next, I shall suggest a group-analytic formulation. I shall then go on to describe the clinical implications of taking this approach, and shall describe how ADHD is too important to keep out of the analytic field, and suggest that group analysis has much to offer in the emerging discourse on social interactional neuroscience.