bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of calpain reduces cell apoptosis by suppressing mitochondrial fission in acute viral myocarditis
Authors: Shi Hui , Yu Ying , Liu Xiaoxiao , Yu Yong , Li Minghui , Wang Yucheng , Zou Yunzeng , Chen Ruizhen , Ge Junbo 
Published: August 2021

AbstractCardiomyocyte apoptosis is critical for the development of viral myocarditis (VMC), which is one of the leading causes of cardiac sudden death in young adults. Our previous studies have demonstrated that elevated calpain activity is involved in the pathogenesis of VMC. This study aimed to further explore the underlying mechanisms. Neonatal rat cardiomyocytes (NRCMs) and transgenic mice overexpressing calpastatin were infected with coxsackievirus B3 (CVB3) to establish a VMC model. Apoptosis was detected with flow cytometry, TUNEL staining, and western blotting. Cardiac function was measured using echocardiography. Mitochondrial function was measured using ATP assays, JC-1, and MitoSOX. Mitochondrial morphology was observed using MitoTracker staining and transmission electron microscopy. Colocalization of dynamin-related protein 1 (Drp-1) in mitochondria was examined using immunofluorescence. Phosphorylation levels of Drp-1 at Ser637 site were determined using western blotting analysis. We found that CVB3 infection impaired mitochondrial function as evidenced by increased mitochondrial ROS production, decreased ATP production and mitochondrial membrane potential, induced myocardial apoptosis and damage, and decreased myocardial function. These effects of CVB3 infection were attenuated by inhibition of calpain both by PD150606 treatment and calpastatin overexpression. Furthermore, CVB3-induced mitochondrial dysfunction was associated with the accumulation of Drp-1 in the outer membrane of mitochondria and subsequent increase in mitochondrial fission. Mechanistically, calpain cleaved and activated calcineurin A, which dephosphorylated Drp-1 at Ser637 site and promoted its accumulation in the mitochondria, leading to mitochondrial fission and dysfunction. In summary, calpain inhibition attenuated CVB3-induced myocarditis by reducing mitochondrial fission, thereby inhibiting cardiomyocyte apoptosis.
Like father, like son? A comparison of absolute and relative intergenerational labour income mobility in Germany and the US
Authors: Stockhausen Maximilian 
Published: August 2021

AbstractAre children better off than their parents? This highly debated question in politics and economics is investigated by analysing the trends in absolute and relative intergenerational labour income mobility for Germany and the US. High quality panel data is used for this purpose; the SOEP for Germany and the PSID for the US. In Germany, 67% of sons born between 1955 and 1975 earned a significantly higher real long-run labour income than their fathers. Those with fathers from the lowest earnings bracket were particularly mobile in absolute terms. In contrast, the fraction of US sons earning more than their fathers is 60% on average for the same cohorts. Their share decreased from 66% in the 1956–60 birth cohort to 48% in the 1971–75 birth cohort, while it changed very little in Germany. Overall, absolute as well as relative labour income mobility is larger in Germany than in the US. This indicates that economic growth has been distributed more broadly in Germany than in the US. While the majority of German males has been able to share in the country’s rising prosperity and are better off than their fathers, US males continue to lose ground. Hence, Chetty et al. (Science 356:398–406, 2017) seem to be right when they say that the American Dream is slowly fading away.
May thermal imaging be useful in the assessment of dental anaesthesia? Preliminary study
Authors: Kaszuba Natalia , Kasprzyk-Kucewicz Teresa , Bałamut Karolina , Morawiec Tadeusz , Stanek Agata , Wziątek-Kuczmik Daria , Cholewka Armand 
Published: August 2021

AbstractThe main goal of this study was to find out if thermal imaging may be useful in the evaluation of two types of anaesthetic injections—with and without a vasoconstrictor. There were 20 patients (13 women and 7 men) involved in the study. The group was divided into two subgroups. Patients from the first subgroup received infiltration anaesthesia (so-called: IA) of lidocaine (2 mL) and the second group included patients, who received infiltration anaesthesia (so-called: IAN) of lidocaine with 2% noradrenaline (2 mL). The obtained results showed a significant increase in the average temperature 10 min after the injection. In the IA group, the temperature increase was nearly 1.0 °C what was 0.3 °C higher than in the IAN group. Moreover, temperature changes showed a wide plateau between 10 and 25 min after anesthesia administration. The effect of temperature rise was also observed on the contralateral cheek where there was no intervention renders by a contralateral reflex.
Aspects of the thermogravimetric analysis of liquid mixtures as predictive or interpretation tool for batch distillation
Authors: Tripodi Antonio , Rossetti Ilenia 
Published: August 2021

AbstractThe thermogravimetric analysis when applied to liquid binary mixtures of acetonitrile–water and methanol–water reproduces the whole course of a batch distillation with an appreciable saving of time and materials. The experimental mass and energy balances correlate with good approximation to the vapor–liquid equilibrium compositions without the need of gas-phase measures or thermodynamic models. This technique was here applied for the first time as fast method for distillation design and complementary tool for DSC boiling-point measurements.
Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System
Authors: Ernzen Kyle , Trask Aaron J. , Peeples Mark E. , Garg Vidu , Zhao Ming-Tao 
Published: August 2021

AbstractThe virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 190 million people to date, causing a global pandemic. SARS-CoV-2 relies on binding of its spike glycoprotein to angiotensin-converting enzyme 2 (ACE2) for infection. In addition to fever, cough, and shortness of breath, severe cases of SARS-CoV-2 infection may result in the rapid overproduction of pro-inflammatory cytokines. This overactive immune response is known as a cytokine storm, which leads to several serious clinical manifestations such as acute respiratory distress syndrome and myocardial injury. Cardiovascular disorders such as acute coronary syndrome (ACS) and heart failure not only enhance disease progression at the onset of infection, but also arise in hospitalized patients with COVID-19. Tissue-specific differentiated cells and organoids derived from human pluripotent stem cells (hPSCs) serve as an excellent model to address how SARS-CoV-2 damages the lungs and the heart. In this review, we summarize the molecular basis of SARS-CoV-2 infection and the current clinical perspectives of the bidirectional relationship between the cardiovascular system and viral progression. Furthermore, we also address the utility of hPSCs as a dynamic model for SARS-CoV-2 research and clinical translation.Graphical abstract
Spatial Analysis of Exposure to Traffic-Related Air Pollution in Mexico: Implications for Urban Planning to Improve Public Health
Authors: Garnica-Monroy Ruben , Garibay-Bravo Veronica , Gonzalez-Gonzalez Alonso , Martínez Salgado Hilda , Hernández-Reyes Malinalli 
Published: August 2021

AbstractIn cities, traffic is one of the major determinants for air quality. Studies have shown that proximity to roadways with heavy traffic has been linked with increased incidence and prevalence of a range of health effects such as adverse birth outcomes, dementia, asthma, and increased risk of bronchitis, wheezing, deficits in lung function growth and airway inflammation, especially among children. In Mexico, 103 urban areas have air quality monitoring, whilst more than 2,000 cities lack any information and only 29 have monitoring systems that are robust enough to estimate exposure. This poses serious limitations for environmental and health authorities when aiming at assessing current exposure levels to Traffic-Related Air Pollution (TRAP) with the purpose of designing and implementing policies to reduce the impacts of poor air quality in the population. This study proposes an approach to estimate the population potentially exposed to TRAP using Space Syntax’s accessibility index as the urban form variable. We selected the ten most accessible roads of the five Mexican cities to estimate the proportion of vulnerable population (residents, employees, schoolchildren, hospital patients) with the highest potential exposure to TRAP at a distance of 500 m. Our findings show a similar proportion of the population continually exposed to TRAP due to the proximity to roads with heavy traffic than studies using more complex models. Finally, this study presents alternatives to reduce current population exposure to traffic emissions in Mexican cities.
How do Older Adults Spend Their Time? Gender Gaps and Educational Gradients in Time Use in East Asian and Western Countries
Authors: Kan Man-Yee , Zhou Muzhi , Negraia Daniela Veronica , Kolpashnikova Kamila , Hertog Ekaterina , Yoda Shohei , Jun Jiweon 
Published: August 2021

AbstractThis study is the first to document how older adults in East Asian and Western societies spend their time, across four key dimensions of daily life, by respondent’s gender and education level. To do this, we undertook a pioneering effort and harmonized cross-sectional time-use data from East Asian countries (China, Japan, South Korea, Taiwan) with data from the Multinational Time Use Study (Canada, Denmark, Finland, France, Italy, The Netherlands, Norway, Spain, United Kingdom, United States; to which we refer as Western countries), collected between 2000 and 2015. Findings from bivariate and multivariate models suggest that daily time budgets of East Asian older adults are different from their counterparts in most Western countries. Specifically, gender gaps in domestic work, leisure, and sleep time were larger in East Asian contexts, than in Western countries. Gender gaps in paid work were larger in China compared to all other regions. Higher levels of educational attainment were associated with less paid work, more leisure, and less sleep time in East Asian countries, while in Western countries they were associated with more paid work, less domestic work, and less sleep. Interestingly, Italy and Spain, two Southern European welfare regimes, shared more similarities with East Asian countries than with other Western countries. We interpret and discuss the implications of these findings for population aging research, and welfare policies.
Co-sensing and co-shaping as shared and relational practices in bringing about relational leaders in higher education
Authors: Ramamoorthi Bhavani , Jäppinen Aini-Kristiina , Taajamo Matti 
Published: August 2021

AbstractThe aim of this article is to investigate how and what kinds of relational and shared practices were co-created within a multicultural team in a higher education collaborative learning environment. The students interacted while working towards the shared goal of co-constructing knowledge. The study provides insight into how student teams can actively build collaboration in learning spaces through manifesting relational leadership. Shared and relational practices refer broadly to all the knowledge, attitudes and skills that emerge from team interaction. A compound theoretical framework combining relational leadership and leadership trichotomy was adapted to study what particular factors enable shared and relational practices. The qualitative study drew data from students’ reflections and group discussions in an intervention which served as a space for experimentation in collaboration and dialogue. The results showed that the students practised Co-sensing and Co-shaping to effectively allow knowledge co-construction. A broadening perception of diversity and the perception that barriers were a doorway to new relational possibilities enabled Co-sensing and Co-shaping to work in collaboration. The results of the study could provide new insights for other kinds of higher education learning environments.
Proptosis a borderline between medical and surgical practice: Dysthyroid ophthalmopathy for example
Authors: Aloua Rachid , Kerdoud Ouassime , Belem Ousmane , Kaouani Amine , Konsem Tarcissus , Slimani Faiçal 
Published: August 2021

ABSTRACT

Introduction:
The association hyperthyroidism–exophtalmia is pathognomonic of the Graves disease. Classically, the treatment is based on a pluridisciplinary approach with a precise chronology. Surgical management of dysthyroid orbitopathy is not based on consensus. When confronted with such particular situations; it can be proposed to treat surgically at the same time the endocrine disease and the ophthalmologic complications.

Observation:
The authors report the case of a 67 -year-old man suffering from Graves’ disease with severe bilateral exophthalmia, treated by orbital decompression with a good result after ten months.

Discussion:
This non-conventional approach highlighted by the authors can be useful in particular situations when the medical environment is not optimal. It helps prevent ocular complications caused by Graves' disease and improves the prognosis of patients with low capacities for the survey.

Highlights
Enhanced Turbulent Heat Fluxes Improve Meiyu‐Baiu Simulation in High‐Resolution Atmospheric Models
Authors: Ding Tian , Zhou Tianjun , Chen Xiaolong , Zou Liwei , Li Puxi , Roberts Malcolm J. , Wu Peili 
Published: August 2021

AbstractBased on 10 pairs of atmospheric general circulation models from the Coupled Model Intercomparison Project Phase 6 High Resolution Model Intercomparison Project, we find that high‐resolution models (HRMs, ∼50 km) perform better than low‐resolution models (LRMs, ∼100 km) in simulating the East Asian summer monsoon (EASM) rain belt. We attribute the increased rainfall to enhanced vertical advection of water vapor in the HRMs which is mainly contributed by enhanced vertical motion. Based on moist static energy analyses, the stronger vertical motion in the HRMSs is mainly balanced by enhanced net energy flux into the atmosphere column in the “Meiyu‐Baiu” (MB) region due to the increase of air‐sea turbulent latent heat fluxes along the Kuroshio and sensible heat fluxes over land. The increased net energy flux in the HRMs drives stronger ascending motion, resulting in more realistic rainfall in the MB region. Higher saturated specific humidity determined by finer sea surface temperature, less near‐surface specific humidity along the Kuroshio, and stronger near‐surface winds on western side of the western North Pacific Subtropical High strengthened by the enhanced pressure gradient together contribute to higher ventilation efficiencies and enhanced ocean forcing along the Kuroshio, leading to more turbulent latent heat fluxes in the HRMs. Additionally, drier and less cloudy atmosphere in the HRMs result in more downward shortwave radiation heating over the land, which partly contributes to the increased sensible heat flux. This understanding of the sensitivity of simulated MB to model resolution has implications for precipitation simulation and prediction over East Asia.
Martian Crustal Field Influence on O+ and O2+ Escape as Measured by MAVEN
Authors: Weber Tristan , Brain David , Xu Shaosui , Mitchell David , Espley Jared , Mazelle Christian , McFadden James P. , Jakosky Bruce 
Published: August 2021

AbstractMartian crustal magnetic fields influence the solar wind interaction with Mars in a way that is not fully understood. In some locations, crustal magnetic fields act as “mini‐magnetospheres,” shielding the planet's atmosphere, while in other locations they act as channels for enhanced energy input and particle escape. The net effect of this system is not intuitively clear, but previous modeling studies have suggested that crustal fields likely decrease global ion escape from Mars. In this study, we use data from the Mars Atmosphere and Volatile EvolutioN spacecraft to analyze how crustal magnetic fields influence both global and local ion escape at Mars. We find that crustal fields only increase ion escape if ions are not bound tightly to the magnetic field. Specifically, ion escape is increased only if closed magnetic fields trap 35% or less of energized oxygen ions. In any other case, crustal fields decrease both global and local ion escape by as much as 40% and 80%, respectively. This suggests that the presence of crustal magnetic fields has had a moderate impact on atmospheric ion loss throughout Martian history, potentially influencing the planet's atmospheric evolution and habitability.
Surface‐Wave Tomography of the Northern Canadian Cordillera Using Earthquake Rayleigh Wave Group Velocities
Authors: Estève C. , Gosselin J. M. , Audet P. , Schaeffer A. J. , Schutt D. L. , Aster R. C. 
Published: August 2021

AbstractWe measure fundamental‐mode Rayleigh wave group velocity dispersion from regional earthquakes and employ transdimensional Bayesian tomography to invert for azimuthally anisotropic group velocity maps at 10–60 s periods. Seismic azimuthal anisotropy within the crust and uppermost mantle shows fast‐axis alignment with principal northern Canadian Cordillera (NCC) tectonic structures suggesting large‐scale and coherent deformation across the crust and upper mantle. We extract group velocity dispersion curves at each grid point of the isotropic group velocity maps and invert them independently for VS as a function of depth in a probabilistic framework. At mid‐to‐lower crustal depths, our pseudo 3‐D VS model reveals an anomalously low VS structure (<3.8 km/s) across the NCC, which likely reflects elevated crustal temperatures that buoyantly support regional high elevations. Two high‐velocity regions (≥4.5 km/s) at uppermost mantle depths underpin the edges of the arcuate Mackenzie fold and thrust belt. We observe variations in the dip direction of the high‐velocity craton edge in the upper mantle, from subvertical in the northern NCC to westward in the southern NCC. We interpret a low‐velocity region (≤4.3 km/s) between the Tintina and Denali faults at uppermost mantle depths to reflect upwelling asthenosphere, which likely postdates 430 km of previously estimated Eocene lithosphere‐scale horizontal displacement along the Tintina fault. Our surface‐wave model resolves a high‐velocity region (≥4.4 km/s) dipping north‐northeast below the Wrangell volcanic field, which we interpret as a down‐going segment of the Pacific slab and may contribute to the observed volcanism in the area.
Aqueous Geochemical and Microbial Variation Across Discrete Depth Intervals in a Peridotite Aquifer Assessed Using a Packer System in the Samail Ophiolite, Oman
Authors: Nothaft Daniel B. , Templeton Alexis S. , Boyd Eric S. , Matter Juerg M. , Stute Martin , Paukert Vankeuren Amelia N. ,   The Oman Drilling Project Science Team
Published: August 2021

AbstractThe potential for molecular hydrogen () generated via serpentinization to fuel subsurface microbial ecosystems independent from photosynthesis has prompted biogeochemical investigations of serpentinization‐influenced fluids. However, investigations typically sample via surface seeps or open‐borehole pumping, which can mix chemically distinct waters from different depths. Depth‐indiscriminate sampling methods could thus hinder understanding of the spatial controls on nutrient availability for microbial life. To resolve distinct groundwaters in a low‐temperature serpentinizing environment, we deployed packers (tools that seal against borehole walls during pumping) in two ‐deep, peridotite‐hosted wells in the Samail Ophiolite, Oman. Isolation and pumping of discrete intervals as deep as to below ground level revealed multiple aquifers that ranged in pH from 8 to 11. Chemical analyses and 16S rRNA gene sequencing of deep, highly reacted groundwaters bearing up to , methane () and sulfate () revealed an ecosystem dominated by Bacteria affiliated with the class Thermodesulfovibrionia, a group of chemolithoheterotrophs supported by oxidation coupled to reduction. In shallower, oxidized groundwaters, aerobic and denitrifying heterotrophs were relatively more abundant. High and of (up to and , respectively) indicated microbial oxidation, particularly in waters with evidence of mixing with waters. This study demonstrates the power of spatially resolving groundwaters to probe their distinct geochemical conditions and chemosynthetic communities. Such information will help improve predictions of where microbial activity in fractured rock ecosystems might occur, including beyond Earth.
Assessing Different Plant‐Centric Water Stress Metrics for Irrigation Efficacy Using Soil‐Plant‐Atmosphere‐Continuum Simulation
Authors: Zhang Jingwen , Guan Kaiyu , Peng Bin , Pan Ming , Zhou Wang , Grant Robert F. , Franz Trenton E. , Rudnick Daran R. , Heeren Derek M. , Suyker Andrew , Yang Yi , Wu Genghong 
Published: August 2021

AbstractUnderstanding plant water stress (PWS) in the soil‐plant‐atmosphere‐continuum (SPAC) that connects water supply from soil, water demand from atmosphere, and plant self‐regulation is a prerequisite for efficient irrigation in response to water scarcity. Currently, PWS can be defined in various ways, for example, based on environmental factors and/or plant‐centric metrics. The environment‐based metrics usually do not take plants into consideration. Regarding the existing plant‐centric metrics, their interconnections and abilities to capture the physical water constraints from both soil water supply and atmospheric water demand are still unclear. This research investigates the theoretical foundations behind different PWS metrics, and assesses their efficacy and potentials for irrigation scheduling. This study first investigated the interconnections among different PWS metrics and the co‐regulation of soil moisture and vapor pressure deficit (VPD) on the plant‐centric metrics through an advanced process‐based model, ecosys. We then use ecosys to test different PWS metrics’ performance in guiding irrigation in terms of water use, maize yield, and economic profits. The case study was conducted at sites across a dramatic rainfall gradient in Nebraska, the largest irrigation state in the United States Corn Belt. The ecosys simulation indicates that canopy water potential and stomatal conductance (gs) are the most effective plant‐centric metrics in the SPAC system in indicating PWS. In addition, our findings show that using the plant‐centric metrics‐based irrigation schemes, which capture the co‐regulation of soil moisture and VPD, can improve producers’ economic profits through water savings.