bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement report: Properties of aerosol and gases in the vertical profile during the LAPSE-RATE campaign
Authors: Brus David , Gustafsson Jani , Vakkari Ville , Kemppinen Osku , de Boer Gijs , Hirsikko Anne 
Published: January 2021

Abstract. Unmanned aerial systems (UASs) are increasingly being used as observation platforms for atmospheric applications. The Lower Atmospheric Process Studies at Elevation – a Remotely-piloted Aircraft Team Experiment (LAPSE-RATE) in Alamosa, Colorado, USA, on 14–20 July 2018 investigated and validated different UASs, measurement sensors and setup configurations. Flight teams from the Finnish Meteorological Institute (FMI) and Kansas State University (KSU) participated in LAPSE-RATE to measure and investigate properties of aerosol particles and gases in the lower atmosphere. During the experiment, the performance of different UAS configurations were investigated and confirmed to operate reliably, resulting in a scientifically sound observational dataset. As an example, concentration of aerosols – including two new particle formation events, CO2 and water vapor, and meteorological parameters in the atmospheric vertical profile were measured during the short experiment. Such observations characterizing atmospheric phenomena of this specific environment would have not been possible in any other way and, thus, demonstrate the power of UASs as new, promising tools in atmospheric and environmental research.
Hillslope and groundwater contributions to streamflow in a Rocky Mountain watershed underlain by glacial till and fractured sedimentary bedrock
Authors: Spencer Sheena A. , Anderson Axel E. , Silins Uldis , Collins Adrian L. 
Published: January 2021

Abstract. Permeable sedimentary bedrock overlain by glacial till leads to large storage capacities and complex subsurface flow pathways in the Canadian Rocky Mountain region. While some inferences on the storage and release of water can be drawn from conceptualizations of runoff generation (e.g., runoff thresholds and hydrologic connectivity) in physically similar
watersheds, relatively little research has been conducted in snow-dominated
watersheds with multilayered permeable substrates that are characteristic
of the Canadian Rocky Mountains. Stream water and source water (rain,
snowmelt, soil water, hillslope groundwater, till groundwater, and bedrock
groundwater) were sampled in four sub-watersheds (Star West Lower, Star West Upper, Star East Lower, and Star East Upper) in Star Creek, SW Alberta, to characterize the spatial and temporal variation in source water contributions to streamflow in upper and lower reaches of this watershed. Principal component analysis was used to determine the relative dominance and timing of source water contributions to streamflow over the 2014 and 2015 hydrologic seasons. An initial displacement of water stored in the hillslope over winter (reacted water rather than unreacted snowmelt and rainfall) occurred at the onset of snowmelt before stream discharge responded significantly. This was followed by a dilution effect as snowmelt saturated the landscape, recharged groundwater, and connected the hillslopes to the stream. Fall baseflows were dominated by either riparian water or hillslope groundwater in Star West. Conversely, in Star East, the composition of stream water was similar to hillslope water in August but plotted outside the boundary of the measured sources in September and October. The chemical composition of groundwater seeps followed the same temporal trend as stream water, but the consistently cold temperatures of the seeps suggested deep groundwater was likely the source of this late fall streamflow. Temperature and chemical signatures of groundwater seeps also suggest highly complex subsurface flow pathways. The insights gained from this research help improve our understanding of the processes by which water is stored and released from watersheds with multilayered subsurface
structures.
Gallbladder and Liver Lobe Torsion in a Young Cat Presented with Hemoabdomen
Authors: Picavet Pierre P. , Vidal Pierre-André , Bolen Géraldine , Gommeren Kris , Noël Stéphanie 
Published: January 2021

ABSTRACT
An 11 mo old domestic shorthair presented with acute lethargy. The cat was hypothermic and bradycardic and had pale pink mucous membranes, poor pulses, and a distended abdomen. Point-of-care ultrasound identified significant abdominal effusion, which was diagnosed to be a hemoabdomen. Bloodwork revealed hyperlactatemia, regenerative anemia, neutrophilia, hypoproteinemia, hypoalbuminemia, and increased alanine aminotransferase. The cat received an allotransfusion and a subsequent canine xenotransfusion and received further supportive therapy. After stabilization, abdominal ultrasonography diagnosed a gallbladder and liver lobe torsion with hemoabdomen. Exploratory laparotomy confirmed the torsion of the right medial and quadrate hepatic lobes together with the gallbladder. Cholecystectomy and lobectomy of the affected lobes were performed using a surgical stapler. The cat was discharged after 4 days. Histopathology confirmed hemorrhagic infarction of the liver lobes and gallbladder, consistent with the described torsion, and the hepatic pseudocyst. It also demonstrated a mucocele in the gallbladder. One month postoperatively, the cat had totally recovered. Hepatic lobe torsion without neoplasia is a rare disease in cats, with variable clinical signs. Gallbladder torsion is a hitherto unreported condition in cats. This is the first report of gallbladder and liver lobe torsion with secondary hemoabdomen in a cat, successfully treated by one-stage surgery.
Histopathologic Correlates of Nonmass Enhancement Detected by Breast Magnetic Resonance Imaging
Authors: Torous Vanda F. , Resteghini Nancy A. , Phillips Jordana , Dialani Vandana , Slanetz Priscilla J. , Schnitt Stuart J. , Baker Gabrielle M. 
Published: January 2021

Context.—
Dynamic, contrast-enhanced magnetic resonance imaging (MRI) is a highly sensitive imaging modality used for screening and diagnostic purposes. Nonmass enhancement (NME) is commonly seen on MRI of the breast. However, the pathologic correlates of NME have not been extensively explored. Consequently, concordance between MRI and pathologic findings in such cases may be uncertain and this uncertainty may cause the need for additional procedures.

Objective.—
To examine the histologic alterations that correspond to NME on MRI.

Design.—
We performed a retrospective search for women who underwent breast MRI between March 2014 and December 2016 and identified 130 NME lesions resulting in biopsy. The MRI findings and pathology slides for all cases were reviewed. The follow-up findings on any subsequent excisions were also noted.

Results.—
Among the 130 cases, the core needle biopsy showed 1 or more benign lesions without atypia in 80 cases (62%), atypical lesions in 21 (16%), ductal carcinoma in situ in 22 (17%), and invasive carcinoma in 7 (5%). Review of the imaging features demonstrated some statistically significant differences in lesions that corresponded to malignant lesions as compared with benign alterations, including homogeneous or clumped internal enhancement, type 3 kinetics, and T2 dark signal; however, there was considerable overlap of features between benign and malignant lesions overall. Of 130 cases, 54 (41.5%) underwent subsequent excision with only 6 cases showing a worse lesion on excision.

Conclusions.—
This study illustrates that NME can be associated with benign, atypical, and/or malignant pathology and biopsy remains indicated given the overlap of radiologic features.
Las instalaciones industriales de la tierra de Sevilla a finales del siglo XV
Authors: González Arce José Damián 
Published: January 2021

Unos informes del concejo de Sevilla de la década de 1490, sobre una serie de pueblos bajo su jurisdicción, nos permiten conocer qué inmuebles se hallaban en ellos dedicados a actividades productivas. Es una documentación excepcional que hace posible diferenciar por comarcas, y en función de otros sectores como la agricultura o el comercio, cuáles de ellas tuvieron mayor dedicación industrial, de qué tipo de sector se trató y por qué se radicó en unos lugares y no en otros; así como su influencia en el crecimiento económico y demográfico local. Para llegar a la conclusión de que la menor dotación de recursos para la agricultura, junto con la disponibilidad de otros como la abundancia de agua para instalaciones molinares u hornos cerámicos, fueron el motor para el crecimiento manufacturero de las regiones más montañosas del reino de Sevilla.
Some reports of the council of Seville of the 1490s, on a series of towns under their jurisdiction, allow us to know which buildings were in them dedicated to productive activities. It is an exceptional documentation that makes it possible to differentiate by regions and, depending on other sectors such as agriculture or commerce, which of them had greater industrial dedication, what type of sector was the principal and why it was located here and not in others districts; as well as its influence on local economic and demographic growth. To reach the conclusion that the lower endowment of resources for agriculture, together with the availability of others such as the abundance of water for mills or ceramic furnaces, were the engine for the manufacturing growth of the most mountainous regions of the kingdom of Seville.
tutorización proactiva como factor de mejora en los resultados de la formación online
Authors: Vercher-Ferrándiz Marisa 
Published: January 2021

En el presente trabajo de investigación se plantea como hipótesis que un modelo de tutorización proactiva, centrado en el acompañamiento y seguimiento continuo del estudiante online, mejora la tasa de aprobados y la satisfacción de los estudiantes. Para validar dicha hipótesis se describen y comparan los resultados de las encuestas de satisfacción y la tasa de aprobados de los cursos impartidos a través del Plan de Estudios Coordinados en Asesoría Financiera del Centro de Formación Permanente de la Universitat Politècnica de València, incluyéndose en el estudio 27 cursos que siguen un modelo de tutorización proactiva con un total de 5.613 estudiantes matriculados y una muestra de 2.500 cuestionarios y 30 cursos que siguen un modelo de tutorización reactiva con un total de 1.862 estudiantes matriculados y una muestra de 583 cuestionarios. Los resultados obtenidos permiten aceptar la hipótesis de partida confirmando que en los cursos que se ha seguido un modelo de tutorización proactiva la tasa de aprobados es un 27% más alta, y al respecto de la satisfacción del alumnado, en ambos tipos de tutorización, el patrón general de respuestas a las encuestas, con ciertas diferencias en la distribución de las mismas, es similar si bien, la satisfacción es más alta en los cursos que han seguido un modelo de tutorización proactivo, mientras que la insatisfacción es mayor en los de tutorización reactiva.
In this research, we established the hypothesis that a proactive tutoring model, focused on the continuous monitoring and follow-up of the online student, improves the rate of approved students and student satisfaction. To validate this hypothesis, we describe and compare the results of the satisfaction surveys and the approved rate of the courses taught through the Coordinated Study Plan in Financial Advisory of the Center for Permanent Training of the Polytechnic University of Valencia. We included in the research 27 courses that follow a proactive tutoring model with a total of 5.613 students enrolled and a sample of 2.500 questionnaires and 30 courses that follow a reactive tutoring model with a total of 1.139 students enrolled with a sample of 583 questionnaires. The results obtained permit accepting the initial hypothesis, confirming that in the courses that a proactive tutoring model was followed, the approved rate is 27% higher and regarding student satisfaction in both types of tutoring the general pattern of responses to the survey, with certain differences in their distribution, were similar, although satisfaction is higher in courses that have followed a proactive tutoring model, while dissatisfaction is greater in those with a reactive tutoring.
Using the Natural Fixative from Canarium Resin of Vietnam
Authors: Hai Le Huy , Truc Le Mai Xuan 
Published: January 2021

Aim and Objectives: Nowadays, the fixative substance from natural materials is gradually replacing the fixative substance that has been synthesized from chemicals. The purpose of the study in this research is that we created a natural fragrance from Vietnamese raw material with a fixative from Canarium Album (Lour) as a natural fixative to replace artificial fixative. Canarium plant is scientifically known as Canarium Album (Lour) Raensch of the Burseraceae family. Canarium Album L. is distributed in most of Northern provinces, central Highlands, and Southeast of Vietnam.
Materials and Methods: The method of this process is resin extraction by volatile solvents. We use a knife to cut into the trunk and let the resin run out, then harvest this resin to make fixative. The resin is dissolved in alcohol 96% and the distilled alcohol is removed to obtain absolute Canarium. Evaluation method of the ability of absolute Canarium is performed by comparing it with other fixatives in fragrances. Raw canarium resins is taken directly from canarium plants then refined absolute canarium as the natural fixative. We use this fixative substance in combinations of floral, woody smells and comparison with traditional artificial fixative as Musk ketone, Musk xylene, Musk ambrette.
Results: The comparison results show that the ability to keep the fragrance of scent is lower than musk ambrette, musk ketone but it is better than musk xylene. Thus, canarium resin can be used as a natural fixative to replace artificial fixative in fragrance.
Conclusions: Through research and experiment, we can see Canarium resin is precious. It can be used as a good fixative in aromatherapy. This is a natural resin, a kind of resource available in Vietnam. Therefore, it is recommended for further research, exploitation, and effective use of this resource.
Green Synthesis of Silver Nanoparticles Using Some Medicinal Plants
Authors: Jalab Joud , Kitaz Adawia , Abdelwahed Wassim , Kayali Rawaa Al- 
Published: January 2021

Aims: The green synthesis of silver nanoparticles in an eco-friendly, economical and more effective approach using (Acacia cyanophylla, Phlomis syriaca and Scolymus hispanicus) plants extracts and describing their main chemical properties and study the effect of its chemical composition on producing silver nanoparticles.
Methodology: In this study, aqueous and ethanolic extracts of the three plants were evaluated for antioxidant activity using 2,2-diphenyl-l-picrylhydrazyl (DPPH) assay, Total polyphenol and flavonoid contents were determined using spectrophotometric method, but total saponins were determined by weight method, The synthesis of silver nanoparticles was performed by a reduction method using aqueous silver nitrate solution and aqueous extracts of the three plants. Then study its characterization in a number of ways, such as visual inspection, UV-Vis spectroscopy and dynamic light scattering.
Results: The results showed that the total phenolic content ranged in extracts between (13.08 ±2.279 to 98.39 ±4.755 mg GAE/g DW). While the total flavonoid contents varied from (19.83 ±2.384 to 121.64 ±6.469 mg RE/g DW. Antioxidant activity was expressed as IC50 and the obtained results ranged from (IC50= 0.027 ±0.00038 to 0.878 ±0.045 mg/ml), the results indicated that the ethanolic Acacia cyanophylla extract from the six examined extracts showed the highest phenolic and flavonoid concentration and strong antioxidant activity. Also, the saponins content in the three plants ranged from (0.46 to 2.53)% and the highest amount of saponins reported in Acacia cyanophylla plant. The silver nanoparticles prepared using Acacia cyanophylla extract have reported visible yellowish brown color formation and the absorption peak at 460 nm indicates the biosynthesis of silver nanoparticles and they have average diameter (134.1) nm and the polydispersity index (PdI) was suitable (0.260).
Conclusion: Acacia cyanophylla extract has been considered as the best reducing agent among the selected plant extracts for the preparation of stable colloidal silver nanoparticles, this is due to their high content of flavonoids, phenols and saponins.
Clinico-pathological Outcomes of Men with Initial Likert 2 Multiparametric Magnetic Resonance Imaging of the Prostate: Findings from a Case Series in a Non-teaching Hospital in UK
Authors: Duckett Abigail , Hughes Stephen , Jameel Basharat , Yehia Mohamed , Seipp Christian , Agarwal Sanjay , Shergill Iqbal 
Published: January 2021

Introduction: With the recent introduction of Multiparametric MRI (MP-MRI) for suspected prostate cancer, we investigated the clinic-pathological outcome of men who were suspected to have prostate cancer but in whom initial MP-MRI was negative (Likert 2).
Methods: Demographic and clinico-pathological outcomes data were analysed in men, with minimum 2 year follow up, who had undergone investigation for suspected prostate cancer with a negative (Likert 2) initial MP-MRI. The primary outcome was subsequent identification of prostate cancer in this cohort. Secondary outcome measures included correlation of prostate volume, presence of previous prostate biopsy, age, Prostate Specific Antigen (PSA) dynamics (pre and post MP-MRI scan), Digital Rectal Examination (DRE) findings and follow-up in months with the primary outcome.
Results: With respect to the primary outcome of this study, prostate cancer was identified in 8.7% of men only (n=4). Of these, two cases were low risk and two were high risk. With regards the secondary outcome measures, there was a positive correlation between PSA dynamics, age at MP-MRI and follow-up in months with subsequent diagnosis of prostate cancer, although this was not statistically significant. There was no prostate cancer specific mortality or morbidity in this cohort.
Conclusions: In this study, despite initial negative MP-MRI scan, prostate cancer was subsequently diagnosed in 4 men (8.7%). Reassuringly, this compares very favourably to the negative predictive value (89%) from the PROMIS trial and as such, adds an important body of work to the contemporary literature on modern diagnosis of suspected prostate cancer.
Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta
Authors: Ming Tinghong , Huan Hengshang , Su Chang , Huo Chunheng , Wu Yan , Jiang Qinqin , Qiu Xiaoting , Lu Chenyang , Zhou Jun , Li Ye , Su Xiurong 
Published: January 2021

For marine invertebrates with no adaptive immune system, ferritin is a major intracellular iron‐storage protein with a critical role in innate immunity. Here, we present the crystal structures of two novel ferritins [Fer147 and Phascolosoma esculenta ferritin (PeFer)] from the marine invertebrate P. esculenta, which resides in muddy‐bottom coastal regions. Fer147 and PeFer exhibit the 4‐3‐2 symmetry of cage‐like hollow shells containing 24 subunits, similar to other known ferritins. Fer147 and PeFer contain both the conserved ferroxidase center and threefold channels. Subtle structural differences in the putative nucleation sites suggest possible routes of metal ion movement in the protein shells. However, the marked variation in the electrostatic potential of the threefold channels in Fer147 and the fourfold channels in PeFer suggests significant diversity between Fer147 and PeFer in terms of metal ion aggregation and cation exclusion. In summary, the presented crystal structures may serve as references for studies of the iron‐storage mechanism of additional ferritins from marine invertebrates.
Vendor‐independent skin dose mapping application for interventional radiology and cardiology
Authors: Krajinović Marko , Kržanović Nikola , Ciraj‐Bjelac Olivera 
Published: January 2021

AbstractPurposeThe purpose of this paper is to present and validate an originally developed application SkinCare used for skin dose mapping in interventional procedures, which are associated with relatively high radiation doses to the patient’s skin and possible skin reactions.MethodsSkinCare is an application tool for generating skin dose maps following interventional radiology and cardiology procedures using the realistic 3D patient models. Skin dose is calculated using data from Digital Imaging and Communications in Medicine (DICOM) Radiation Dose Structured Reports (RDSRs). SkinCare validation was performed by using the data from the Siemens Artis Zee Biplane fluoroscopy system and conducting “Acceptance and quality control protocols for skin dose calculating software solutions in interventional cardiology” developed and tested in the frame of the VERIDIC project. XR‐RV3 Gafchromic films were used as dosimeters to compare peak skin doses (PSDs) and dose maps obtained through measurements and calculations. DICOM RDSRs from four fluoroscopy systems of different vendors (Canon, GE, Philips, and Siemens) were used for the development of the SkinCare and for the comparison of skin dose maps generated using SkinCare to skin dose maps generated by different commercial software tools (Dose Tracking System (DTS) from Canon, RadimetricsTM from Bayer and RDM from MEDSQUARE). The same RDSRs generated during a cardiology clinical procedure (percutaneous coronary intervention—PCI) were used for comparison.ResultsValidation performed using VERIDIC's protocols for skin dose calculation software showed that PSD calculated by SkinCare is within 17% and 16% accuracy compared to measurements using XR‐RV3 Gafchromic films for fundamental irradiation setups and simplified clinical procedures, respectively. Good visual agreement between dose maps generated by SkinCare and DTS, RadimetricsTM and RDM was obtained.ConclusionsSkinCare is proved to be very convenient solution that can be used for monitoring delivered dose following interventional procedures.
Myelin‐specific T cells in animals with Japanese macaque encephalomyelitis
Authors: Govindan Aparna N. , Fitzpatrick Kristin S. , Manoharan Minsha , Tagge Ian , Kohama Steven G. , Ferguson Betsy , Peterson Samuel M. , Wong Grayson S. , Rooney William D. , Park Byung , Axthelm Michael K. , Bourdette Dennis N. , Sherman Larry S. , Wong Scott W. 
Published: January 2021

AbstractObjectiveTo determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and periphery.MethodsMononuclear cells (MNCs) from CNS lesions, cervical lymph nodes (LNs) and peripheral blood of Japanese macaques (JMs) with JME, and cervical LN and blood MNCs from healthy controls or animals with non‐JME conditions were analyzed for the presence of myelin‐specific T cells and changes in interleukin 17 (IL‐17) and interferon gamma (IFNγ) expression.ResultsDemyelinating JME lesions contained CD4+ T cells and CD8+ T cells specific to myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), and/or proteolipid protein (PLP). CD8+ T‐cell responses were absent in JME peripheral blood, and in age‐ and sex‐matched controls. However, CD4+ Th1 and Th17 responses were detected in JME peripheral blood versus controls. Cervical LN MNCs from eight of nine JME animals had CD3+ T cells specific for MOG, MBP, and PLP that were not detected in controls. Mapping myelin epitopes revealed a heterogeneity in responses among JME animals. Comparison of myelin antigen sequences with those of JM rhadinovirus (JMRV), which is found in JME lesions, identified six viral open reading frames (ORFs) with similarities to myelin antigen sequences. Overlapping peptides to these JMRV ORFs did not induce IFNγ responses.InterpretationsJME possesses an immune‐mediated component that involves both CD4+ and CD8+ T cells specific for myelin antigens. JME may shed new light on inflammatory demyelinating disease pathogenesis linked to gamma‐herpesvirus infection.