bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma
Authors: Caso Raul , Connolly James G. , Zhou Jian , Tan Kay See , Choi James J. , Jones Gregory D. , Mastrogiacomo Brooke , Sanchez-Vega Francisco , Nguyen Bastien , Rocco Gaetano , Molena Daniela , Sihag Smita , Adusumilli Prasad S. , Bott Matthew J. , Jones David R. 
Published: July 2021

AbstractWhile next-generation sequencing (NGS) is used to guide therapy in patients with metastatic lung adenocarcinoma (LUAD), use of NGS to determine pathologic LN metastasis prior to surgery has not been assessed. To bridge this knowledge gap, we performed NGS using MSK-IMPACT in 426 treatment-naive patients with clinical N2-negative LUAD. A multivariable logistic regression model that considered preoperative clinical and genomic variables was constructed. Most patients had cN0 disease (85%) with pN0, pN1, and pN2 rates of 80%, 11%, and 9%, respectively. Genes altered at higher rates in pN-positive than in pN-negative tumors were STK11 (p = 0.024), SMARCA4 (p = 0.006), and SMAD4 (p = 0.011). Fraction of genome altered (p = 0.037), copy number amplifications (p = 0.001), and whole-genome doubling (p = 0.028) were higher in pN-positive tumors. Multivariable analysis revealed solid tumor morphology, tumor SUVmax, clinical stage, SMARCA4 and SMAD4 alterations were independently associated with pathologic LN metastasis. Incorporation of clinical and tumor genomic features can identify patients at risk of pathologic LN metastasis; this may guide therapy decisions before surgical resection.
Temperature dependent moiré trapping of interlayer excitons in MoSe2-WSe2 heterostructures
Authors: Mahdikhanysarvejahany Fateme , Shanks Daniel N. , Muccianti Christine , Badada Bekele H. , Idi Ithwun , Alfrey Adam , Raglow Sean , Koehler Michael R. , Mandrus David G. , Taniguchi Takashi , Watanabe Kenji , Monti Oliver L. A. , Yu Hongyi , LeRoy Brian J. , Schaibley John R. 
Published: July 2021

AbstractMoSe2–WSe2 heterostructures host strongly bound interlayer excitons (IXs), which exhibit bright photoluminescence (PL) when the twist angle is near 0° or 60°. Over the past several years, there have been numerous reports on the optical response of these heterostructures but no unifying model to understand the dynamics of IXs and their temperature dependence. Here we perform a comprehensive study of the temperature, excitation power, and time-dependent PL of IXs. We observe a significant decrease in PL intensity above a transition temperature that we attribute to a transition from localized to delocalized IXs. Astoundingly, we find a simple inverse relationship between the IX PL energy and the transition temperature, which exhibits opposite power-dependent behaviors for near 0° and 60° samples. We conclude that this temperature dependence is a result of IX–IX exchange interactions, whose effect is suppressed by the moiré potential trapping IXs at low temperature.
Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
Authors: Andersen-Civil Audrey Inge Schytz , Leppä Milla Marleena , Thamsborg Stig M. , Salminen Juha-Pekka , Williams Andrew R. 
Published: July 2021

AbstractProanthocyanidins (PAC) are dietary compounds that have been extensively studied for beneficial health effects due to their anti-inflammatory properties. However, the structure-function relationships of PAC and their mode-of-action remain obscure. Here, we isolated a wide range of diverse PAC polymer mixtures of high purity from plant material. Polymer size was a key factor in determining the ability of PAC to regulate inflammatory cytokine responses in murine macrophages. PAC polymers with a medium (9.1) mean degree of polymerization (mDP) induced substantial transcriptomic changes, whereas PAC with either low (2.6) or high (12.3) mDP were significantly less active. Short-term oral treatment of mice with PAC modulated gene pathways connected to nutrient metabolism and inflammation in ileal tissue in a polymerization-dependent manner. Mechanistically, the bioactive PAC polymers modulated autophagic flux and inhibited lipopolysaccharide-induced autophagy in macrophages. Collectively, our results highlight the importance of defined structural features in the health-promoting effects of PAC-rich foods.
Gastric lipase can significantly increase lipolysis and carotenoid bioaccessibility from plant food matrices in the harmonized INFOGEST static in vitro digestion model
Authors: Iddir Mohammed , Porras Yaruro Juan Felipe , Larondelle Yvan , Bohn Torsten 
Published: July 2021

Carotenoid bioaccessibility depends on gastric lipase, but it is often omitted in in vitro digestion. Adding rabbit gastric lipase was superior to R. niveus/oryzae in boosting carotenoid micellization (≈2-fold), but all 3 improved fatty acid release.
Prognostic value of neuron-specific enolase in patients with advanced and metastatic non-neuroendocrine non-small cell lung cancer
Authors: Yan Peng , Han Yiming , Tong Anna , Liu Jie , Wang Xinyu , Liu Chuanyong 
Published: July 2021

Abstract
Background: Increased serum neuron-specific enolase (NSE) level was found in a substantial proportion (30–69%) of patients with non-small-cell lung cancer (NSCLC), but little was known about the clinical properties of NSE in NSCLC.
Objective: We aimed to assess the level of serum NSE to predict prognosis and treatment response in patients with advanced or metastatic non-neuroendocrine NSCLC.
Methods: We retrospectively analyzed 363 patients with advanced and metastatic NSCLC between January 2011 and October 2016. The serum NSE level was measured before initiation of treatment.
Results: Patients with high NSE level (≥26.1 ng/ml) showed significantly shorter progression-free survival (PFS) (5.69 vs 8.09 months; P=0.02) and significantly shorter overall survival (OS) than patients with low NSE level (11.41 vs 24.31 months; P=0.01).
NSE level was an independent prognostic factor for short PFS (univariate analysis, hazard ratio [HR] = 2.40 (1.71–3.38), P&lt;0.001; multivariate analysis, [HR] = 1.81 (1.28–2.56), P=0.001) and OS (univariate analysis, [HR] = 2.40 (1.71–3.37), P&lt;0.001; multivariate analysis, [HR] = 1.76 (1.24–2.50), P=0.002).
Conclusion: The survival of NSCLC patients with high serum NSE level was shorter than that of NSCLC patients with low serum NSE levels. Serum NSE level was a predictor of treatment response and an independent prognostic factor.
First-Year Graduate Clinicians' Perceptions of Synchronous Telepractice Delivery
Authors: Roman Aaron M. , Kim Sojung , Means Jennifer W. 
Published: July 2021

Purpose
Telepractice in speech-language pathology is a continually evolving part of clinical service delivery. Despite its popularity, little evidence exists on how to educate beginning-level student clinicians in telepractice provision. The purpose of this study is to assess the perceived comfort level of first-year graduate clinicians providing telepractice services during the COVID-19 pandemic. Identifying these perceptions and potential challenges allows faculty and clinic supervisors to improve their instruction for telepractice service delivery.

Method

Survey data were collected from graduate clinicians (
n
= 23) during the onset of the COVID-19 pandemic regarding their perceptions of telepractice-based clinical service delivery.

Results
All student clinicians surveyed had accrued between 1 and 15 hr of telepractice hours during the Spring 2020 semester (February–May 2020). Student clinicians were largely comfortable finding evidence to support therapies, providing basic therapeutic services, and completing clinical documentation for telepractice sessions. They noted challenges in using cloud-based computing software and selecting appropriate therapeutic intervention approaches for telepractice services.

Conclusion
The findings from this study may provide insight into preservice training using telepractice and yield recommendations in integrating telepractice into early graduate training curricula.
Hypernatremic Dehydration Risk Factors in Newborns: Prospective Case-Controlled Study
Authors: Celik Kiymet , Ozbek Aylin , Olukman Ozgur , Isleten Figen , Calkavur Sebnem 
Published: July 2021

AbstractBackground The prevalence of hypernatremic dehydration (HND) has increased in recent years most likely due to insufficient intake of breast milk as the most important factor. This study aimed to investigate risk factors of HND.Methods In this study, 47 neonates whom were diagnosed to have HND were included in the study group and 96 healty neonates whom were included in the control group. While demographic data of the patients were recorded, mothers were asked to fill out the sociodemographic/ psychosocial data form, Edinburgh Postpartum Depression Scale(EPDS) and STAI I and II State and Trait Anxiety Scale. Breast milk sodium concentrations were studied from mothers of all infants. The relationship between the development of neonatal HND and risk factors affecting this condition were evaluated.Results Being the first-born baby of the family was found to be a significant risk factor for HND. Breast milk sodium concentration was 25.8±7.9 mmol/L in the HND group which was significantly higher than the control group. Median depression score was similar in both groups and there was no statistical difference in terms of groups. The anxiety score was higher in the control group compared to the study group. There was no difference in terms of other sociodemographic / psychosocial data of mothers.Conclusion Primiparity or insufficient breastfeeding may result in elevated breast milk sodium levels and related neonatal HND. Breastfeeding support should principally target primiparous women to improve breastfeeding outcomes like as especially HND.
Horizon: Microfluidic platform for the production of therapeutic microbubbles and nanobubbles
Authors: Abou-Saleh Radwa H. , Armistead Fern J. , Batchelor Damien V. B. , Johnson Benjamin R. G. , Peyman Sally A. , Evans Stephen D. 
Published: July 2021

Microbubbles (MBs) have a multitude of applications including as contrast agents in ultrasound imaging and as therapeutic drug delivery vehicles, with further scope for combining their diagnostic and therapeutic properties (known as theranostics). MBs used clinically are commonly made by mechanical agitation or sonication methods, which offer little control over population size and dispersity. Furthermore, clinically used MBs are yet to be used therapeutically and further research is needed to develop these theranostic agents. In this paper, we present our MB production instrument “Horizon,” which is a robust, portable, and user-friendly instrument, integrating the key components for producing MBs using microfluidic flow-focusing devices. In addition, we present the system design and specifications of Horizon and the optimized protocols that have so far been used to produce MBs with specific properties. These include MBs with tailored size and low dispersity (monodisperse); MBs with a diameter of ∼2 μm, which are more disperse but also produced in higher concentration; nanobubbles with diameters of 100–600 nm; and therapeutic MBs with drug payloads for targeted delivery. Multiplexed chips were able to improve production rates up to 16-fold while maintaining production stability. This work shows that Horizon is a versatile instrument with potential for mass production and use across many research facilities, which could begin to bridge the gap between therapeutic MB research and clinical use.
The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice
Authors: Zheng Kezhi , Wang Lili , Zeng Longjun , Xu Dachao , Guo Zhongxin , Gao Xiquan , Yang Dong-Lei 
Published: July 2021

Significance
Rice RNA polymerase V (Pol V) influences the accumulation of 24-nucleotide small interfering RNAs (24-nt siRNAs) in a locus-specific manner. Accumulation of 24-nt siRNAs is dependent on Pol V on loci with high CHH methylation levels, low CG and CHG methylation levels, and high active histone modifications. In contrast, a low methylation level in the CHH context, high methylation levels in CG and CHG contexts, and enrichment of repressive histone modifications predispose 24-nt siRNA accumulation to be independent of Pol V. DNA methylation is essential for 24-nt siRNA biosynthesis on Pol V–dependent loci but not on Pol V–independent loci. Our results suggest that monocot Pol V–transcribed scaffold RNAs are essential for reproductive development and 24-nt siRNA biosynthesis on euchromatin.
Membrane association of importin α facilitates viral entry into salivary gland cells of vector insects
Authors: Ma Yonghuan , Lu Hong , Wang Wei , Zhu Jiaming , Zhao Wan , Cui Feng 
Published: July 2021

Significance
The importin α family is well known as a cargo transporter from the cytoplasm to the nucleus, with diverse functions in eukaryotes. However, some members of the importin α family also localize to the cell membrane. Here, we report that a cell membrane–associated importin α takes part in viral transmission by vector insects. Importin α2 of the small brown planthopper binds the rice stripe virus on the proteoglycans of the cell membrane and efficiently controls viral entry into insect salivary glands and subsequent transmission to rice. These findings not only demonstrate the specific function of importin α in the cell membrane utilized by viruses, but also provide a promising target gene for preventing outbreaks of rice stripe disease.
Sulfatides are endogenous ligands for the TLR4–MD-2 complex
Authors: Su Lijing , Athamna Muhammad , Wang Ying , Wang Junmei , Freudenberg Marina , Yue Tao , Wang Jianhui , Moresco Eva Marie Y. , He Haoming , Zor Tsaffrir , Beutler Bruce 
Published: July 2021

SignificanceToll-like receptor 4 (TLR4) is an innate immune receptor that initiates inflammation when activated by bacterial lipopolysaccharide. It may also be activated by endogenous host molecules, leading to autoinflammation and autoimmunity. We demonstrate that several sulfatide species, natural membrane glycolipids in mammals, are bona fide ligands for TLR4 and its coreceptor myeloid differentiation factor-2 (MD-2). Sulfatides with lipid chains containing 12 or 16 carbon atoms are agonists of mouse TLR4 and antagonists of human TLR4. We determined the crystal structure of the mouse TLR4–MD-2 extracellular domain in complex with C16-sulfatide at 2.1-Å resolution, providing definitive evidence of direct interaction. Structure–activity relationship studies suggest a structural basis for the differential effects of sulfatides interacting with human and mouse receptors.
Fast-shear-flow generated multiple magnetic islands and Alfvénic resonance layers in magnetic reconnection
Authors: Li LingJie 
Published: July 2021

Abstract
Magnetic reconnection in the presence of fast sheared plasma flows is investigated using two-dimensional incompressible resistive MHD simulation. It is found that if the initial shear-flow velocity is sufficiently large, multiple Alfvén resonance layers can be formed in the inflow region away from the reconnection separatrices. In particular, two Alfvén layers are formed when the initial asymptotic flow velocity is twice the Alfvén velocity. The Alfvén layers are located in the narrow regions where the flow speed equals or twice the local Alfvén speed. The formation and evolution of the Alfvén layers and magnetic islands are analyzed. It is suggested that the geometry of the magnetic field lines during the islands complex inosculated process is related to the local distribution of velocities. The results may be applied to where the magnetic reconnection occurs with large plasma shear flows in laboratory and space plasma.
Application of an alternative framework for measuring progress towards SDG 7.1
Authors: Pelz Setu , Pachauri Shonali , Rao Narasimha 
Published: July 2021

Abstract
Global progress towards Sustainable Development Goal 7.1: ‘By 2030, ensure universal access to affordable, reliable and modern energy services’ continues to be measured by mere access to energy carriers, using binary indicators that inadequately reflect the multi-dimensional nature of the goal. In this work, we describe and apply an alternative framework to track critical dimensions of energy provisioning and household capabilities that aligns more closely with the original SDG 7.1 target wording. We provide new empirical evidence from ten countries describing the extent to which the current indicators underestimate energy poverty and neglect decent access. We find that households officially counted as having access to modern energy sources, in many instances, still benefit only from minimal energy services, receive unreliable energy supply, and struggle with being able to afford energy services they need to enjoy a decent standard of living. We also find that poorer households are systematically over-represented in this population and are more likely to suffer multi-dimensional constraints when counted served by the current indicators. Notwithstanding challenges in data collection and standardisation, we argue that we must improve on binary indicators for measuring progress towards SDG 7.1, to pave the way for agenda setting and policy development that recognises and addresses broad inequities in household capabilities to use modern energy towards achieving a decent living standard.
Thermal utilization of spent sorptive material from phythogenic waste
Authors: Stepanova S V , Yu Garmonov S , Pavlov G I , Kazakova U A 
Published: July 2021

Abstract
The thermal utilization of spent sorptive materials based on phythogenic waste in a pulsating combustion unit is proposed. The combustion temperature was determined based on the method of differential scanning calorimetry and derivatography. The hazard class of the produced ash is calculated on the basis of elemental analysis.
Physicochemical treatment of waste water from complex organic substances
Authors: Ksenofontov B S , Taranov R A , Vinogradov M S , Senik E V 
Published: July 2021

Abstract
This paper considers with the issues of extracting polycyclic hydrocarbons from wastewaters by using physicochemical technology, including the use of flotation, settling, filtration, adsorption, ozonation. The usage of this technology could significantly reduce the concentration of such hazardous substances as benzopyrene in the treated wastewaters. Under certain regimes of wastewaters treatment using physicochemical technology, the concentration of benzopyrene does not exceed the standard values. The prospects for the usage of bio-flotation harvesters for the treatment of wastewaters, which contains complex organic substances are indicated.
Why we need to purify the air from carbon dioxide
Authors: Tkachenko Yu L , Morozov S D , Sherbakova I S , Rovnyagina A S 
Published: July 2021

Abstract
Acute and chronic exposure on humans of carbon dioxide contained both in the air of enclosed spaces and in the atmosphere of the Earth are described. The current tendencies of increasing the CO2 content in the external and internal aerial environment of buildings are shown. A forecast of the consequences of an increase in the content of carbon dioxide in the atmosphere for human health is presented. The paper presents information on the technological systems created by the “Carbon Engineering” enterprise for cleaning the atmosphere from CO2, allowing to eliminate the accumulation of carbon dioxide in the air, regardless of the reasons causing the accumulation. The use of technologies of physicochemical and bio regeneration of the chemical composition of air and water is proposed to create an artificial environment favorable for humans.
Synthesizing phosphorus hydrazones as a method to dispose unsymmetrical dimethylhydrazine
Authors: Ryapisova L V , Solyashinova O A , Fridland S V , Khasanova V K 
Published: July 2021

Abstract
This paper deals with studying the possibility of obtaining a phosphorus-containing derivative of acetone N, N-dimethylhydrazone. It is shown that the phosphorylated derivative is not obtained by directly phosphorylating the acetone dimethylhydrazone, but via Abramov reaction from aminoacetone that is afforded in the interaction of diphenylphosphorous acid with the acetone N, N-dimethylhydrazone.
Investigation of the pressure drop on the filtration and protective baffles of a hydrodynamic vibration filter using ANSYS CFX
Authors: Frolov N P , Devisilov V A 
Published: July 2021

Abstract
This paper considers the relationship of the pressure drop at the filtration baffle of a hydrodynamic vibration filter with and without protective baffle for different operation parameters like baffle flowrate and filtration baffle rotation speed. The simulations were done using ANSYS CFX and nonlinear Darcy’s law.
Investigation of the interaction of CO2 and NH3 in the gaseous phase
Authors: Bakirov N G , Makhotkin A F , Starkova A V 
Published: July 2021

Abstract
In the modern world, the issue of increasing the production of soda ash is acute. However, the mechanism of chemisorption CO2 by the ammoniated brine and does not take into account the share of the gas reaction. Regularities of the mechanism and kinetics of the gas-phase reaction of the interaction of the mixture CO2 and NH3 must be taken into account in the conditions of soda ash production both at the stages of ammoniated brine production and at the stages of sodium bicarbonate production.
Ecotoxicological sensing of the arctic seas
Authors: Korsak M N , Mosharov S A 
Published: July 2021

Abstract
The results of ecotoxicological monitoring - studies of the resistance of marine phytoplankton communities of the Arctic seas to some pollutants are presented. The influence of pollutants on primary productivity was assessed as the most sensitive biological process. It is shown that the method of ecotoxicological sounding makes it possible to identify areas most susceptible to chronic pollution, leading to a decrease in biological productivity.
Investigation of the process of desorption of oil-saturated waste of feit production
Authors: Sanatullova Z T , Shaikhiev I G 
Published: July 2021

Abstract
Has been investigated the possibility of using keratin-containing waste of felt production - knop - as a sorption material for oils. The value of the activation energy was determined, which was 27.86 kJ/mol. It was found that the process of interaction of knop with oil is physical and occurs due to changes in the Van der Waals forces.
Study of the oxidation process of divalent iron in aqueous solutions during aeration through ceramic membranes modified by layered double hydroxides
Authors: Averina Yu M , Subcheva E N , Kurbatov A Yu , Pshenichkina T V , Boldyrev V S 
Published: July 2021

Abstract
The work considers the issues of intensification of the process of purification of natural waters from compounds of bivalent iron, namely the stage of its oxidation. In the experiments, corundum-based ceramic membranes with a deposited layer of aluminum oxide and the same membranes, but modified with layered double hydroxide (LDH) based on the trivalent iron ion, were used as the aerator material. Experiments were carried out to compare the aeration modes for both types of membranes; an aquarium aerator was taken as a comparison. The contribution of the selective layer with LDH to the oxidation rate of bivalent iron by atmospheric oxygen is shown, which confirms its catalytic activity. The process flow diagram of the aerator is proposed.