bluuebunny/crossref_metadata_2025_split huggingface dataset:
Succinyl-CoA-based energy metabolism dysfunctions in chronic heart failure
Authors: Takada Shingo , Maekawa Satoshi , Furihata Takaaki , Kakutani Naoya , Setoyama Daiki , Ueda Koji , Nambu Hideo , Hagiwara Hikaru , Handa Haruka , Fumoto Yoshizuki , Hata Soichiro , Fukushima Arata , Yokota Takashi , Kang Dongchon , Kinugawa Shintaro , Sabe Hisataka 
Published: December 2021

Abstract
Heart failure (HF) is a leading cause of death and repeated hospitalizations1. HF progression generally involves mitochondrial dysfunction2-4. However, how mitochondria react to chronic HF remains unclear. Here, we show the molecular basis of mitochondrial dysfunction in chronic HF, which is characterized by altered succinyl-CoA metabolism. In myocardial mitochondria of coronary ligated mice, heme synthesis and ketolysis, and enzymes using succinyl-CoA in these events were upregulated, and enzymes synthesizing succinyl-CoA at the tricarboxylic acid (TCA) cycle were also increased. Intriguingly, the ADP-specific, but not the GDP-specific, subunit of succinyl-CoA synthetase, which uses succinyl-CoA in the TCA cycle, was decreased. Myocardial succinyl-CoA levels were significantly reduced in chronic HF, impairing mitochondrial oxidative phosphorylation (OXPHOS). Consequently, the administration of 5-aminolevulinic acid (ALA)5, an intermediate in the pathway from succinyl-CoA to heme synthesis, prevented HF progression in mice. Previous reports also support the presence of succinyl-CoA metabolism abnormalities in HF patients6,7. Our results indicated that changes in succinyl-CoA usage in various energy production systems in myocardial mitochondria is characteristic to chronic HF, and that although similar alterations occur in healthy conditions, such as during strenuous exercise, they may often occur irreversibly in HF. Moreover, nutritional interventions compensating the metabolic changes are likely to provide effective methods to treat HF.
Rotating 5D black holes: Interactions and deformations near extremality
Authors: Castro Alejandra , Pedraza Juan , Toldo Chiara , Verheijden Evita 
Published: December 2021

We study a two-dimensional theory of gravity coupled to matter that
is relevant to describe holographic properties of black holes with two
equal angular momenta in five dimensions (with or without cosmological
constant). We focus on the near-horizon geometry of the near-extremal
black hole, where the effective theory reduces to Jackiw-Teitelboim (JT)
gravity coupled to a massive scalar field. We compute the corrections to
correlation functions due to cubic interactions present in this theory.
A novel feature is that these corrections do not have a definite sign:
for AdS_55
black holes the sign depends on the mass of the extremal solution. We
discuss possible interpretations of these corrections from a
gravitational and holographic perspective.
We also quantify the imprint of the JT sector on the UV region, i.e. how
these degrees of freedom, characteristic for the near-horizon region,
influence the asymptotically far region of the black hole. This gives an
interesting insight on how to interpret the IR modes in the context of
their UV completion, which depends on the environment that contains the
black hole.
Experimental investigation of simultaneous effect of parabolic trough collector and flat external reflectors on performance of stepped solar still
Authors: Pirkandi Jamasb , Kassaei Farshid , Hashemabadi Mahdi 
Published: December 2021

Abstract
In this research, the performance of a stepped solar still has been experimentally evaluated. For this purpose, a parabolic trough collector has been used to preheat the saline water entering the solar still. Also, two flat external reflectors have been employed to increase the amount of solar energy received by the steps and the collector of the system. The findings of this research indicate that the use of two flat external reflectors is more effective than using the trough collector. Also, it is more efficient to apply both mechanisms simultaneously than to use them separately. According to the obtained results, the distilled water output of the solar still is 760, 1,560, 2,440 and 2,760 ml/m2, respectively, for operating the conventional solar still, using the trough collector, using the two flat external reflectors, and using the collector and reflectors simultaneously. The electrical conductivity due to the presence of salt and chemical substances dissolved in the distilled water discharged from the still is 255, 215, 62 and 38 micro Siemens per centimetre, respectively, for each of the four mentioned cases. These experiments show that by applying the proposed mechanisms, the amount of distilled water can be increased, and its purity can be enhanced.
A importância das atividades do PIBID para a formação inicial de professores
Authors: Dos Santos Lopes Cynthia Loren , Sebastiana Alves Soares Klayriene , Rocha Nunes Ana Néia , Rocha Valesca Paula 
Published: December 2021

O presente estudo objetivou relatar atividades e experiências vivenciadas por licenciandas do curso de Ciências Biológicas desenvolvidas durante a participação no Subprojeto PIBID-Biologia na Unidade Escolar José Patrício Franco, no município de Uruçuí, Piauí. O estudo utilizou-se de uma pesquisa descritiva, do tipo relato de experiência, realizada durante o período de agosto de 2018 a janeiro de 2019. O programa visa antecipar a experiência prática do licenciando ainda na primeira metade do curso com a escola pública de educação básica, contribuindo com a valorização do magistério. A participação no PIBID além de oportunizar uma compreensão ampliada a respeito dos estudantes e profissionais ali inseridos, também favoreceu na busca de identidade profissional enquanto futuras docentes e a relacionar a teoria, vista em âmbito acadêmico, com a prática.
Palavras-chave: Ciências biológicas. Formação docente. Vivências.
Preservação da memória através da fotografia e sua disseminação para a comunidade universitária no âmbito da AGECOM/UFRN
Authors: Moura Rafaela Karoline Galdêncio de , Araújo Francisco de Assis Noberto Galdino de 
Published: December 2021

Apresenta perspectivas relacionadas à preservação de fotografias impressas institucionais no âmbito universitário. Explicita o contexto da informação, caracterizando o documento enquanto suporte de representação da informação. Conceitua a memória para a promoção da comunicação, disseminação da informação e formas de estoque na mente humana. Enfoca a fotografia como meio de representação da informação documental ao qual assume papel fundamental na construção da memória; bem como os elementos constituintes que a tornam meio impresso ou digital. Aborda questões técnicas e reflexivas concernentes à preservação, conservação e disseminação da informação em coleções fotográficas. Esta pesquisa objetivou estudar as formas de acondicionamento e preservação das fotografias da Agência de Comunicação da Universidade Federal do Rio Grande do Norte, bem como perceber se existe divulgação destes materiais para a comunidade universitária. Finaliza o estudo com reflexões acerca da importância da preservação de fotografias para a construção da memória institucional enquanto um todo, com vistas a disseminação da informação ao público interno e externo frente à Universidade Federal do Rio Grande do Norte. Palavras-chave: Memória institucional. Preservação de fotografias. Disseminação da informação. Agência de Comunicação.
Impact of Immunosuppressant Agents on Post Liver Transplant Patients
with COVID-19
Authors: Khodashahi Rozita , Aliakbarian Mohsen , Khodashahi Mandana 
Published: December 2021

Background:
It seems that transplant recipients are at high risk for severe COVID-19,
especially in the presence of comorbidities and immunosuppression. This study aimed to determine
the effects of previous treatment with immunosuppressants and received dosage and the risk of
COVID-19 severity and mortality in liver transplant recipients in various post-transplantation phases
in the Iranian population.

Methods:
This was a cross-sectional study conducted among 24 patients in the post liver transplant
course, who were referred to two transplant centers (Imam Reza and Montaseriyeh hospitals) affiliated
to Mashhad University of Medical Sciences, Mashhad, Iran, during 2020-2021. The demographic
and clinical characteristics of the patients were recorded in a checklist, and the relationships
between various variables were analyzed.

Results:
The majority of the post liver transplant patients(96%) were in the late phase of post-transplantation,
and 8.3% of the cases expired. COVID-19 severity and mortality did not show a significant
relationship with previous treatment with immunosuppressants and received dosage (P>0.05).
In addition, there was no relationship between the symptoms of COVID-19 and immunosuppressant
dosages, except for a headache. No significant correlation was found between immunosuppressants
dosage and laboratory findings, and only prednisolone dosage was found to be correlated
with heart rate (r=-0.62, P=0.03), BUN (r=-0.84, P=0.002), and D-dimer (r=-0.72, P=0.01).

Conclusion:
Severe SARS-CoV-2 infection was reported in the majority of liver transplant recipients.
The severity of COVID-19 was not related to previous treatment with immunosuppressants
and received dosage.
Efficacy and Safety of Mesenchymal Stromal Cells Therapy for
COVID-19 Infection: A Systematic Review and Meta-analysis
Authors: Li Yaxin , Wei Ziyang , Ma Xinyu , Xu Jing , Zhao Xia , Cao Qilong , Di Guohu 
Published: December 2021

Background:
Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease
prevalent worldwide with a high mortality rate, and there is currently no specific medicine to treat
patients.

Objective:
We aimed to assess the safety and efficacy of stem cell therapy for COVID-19 by providing
references for subsequent clinical treatments and trials.

Method:
We systematically searched PubMed, Embase, Cochrane, and Web of Science, using the
following keywords: “stem cell” or “stromal cell” and “COVID-19.” Controlled clinical trials published
in English until 24th August 2021 were included. We followed the PRISMA guidelines and
used Cochrane Collaboration’s tool for assessing the risk of bias. We analysed the data using a
fixed-effect model.

Results:
We identified 1779 studies, out of which eight were eligible and included in this study.
Eight relevant studies consisted of 156 patients treated with stem cells and 144 controls (300 individuals
in total). There were no SAEs associated with stem cell therapy in all six studies, and no significant
differences in AEs (p = 0.09, I2 = 40%, OR = 0.53, 95% CI: 0.26 to 1.09) between the experimental
group and control group were observed. Moreover, the meta-analysis found that stem cell
therapy effectively reduced the high mortality rate of COVID-19 (14/156 vs. 43/144; p<0.0001, I2
= 0%, OR=0.18, 95% CI: 0.08 to 0.41).

Conclusion:
This study suggests that MSCs therapy for COVID-19 has shown some promising results
in safety and efficacy. It effectively reduces the high mortality rate of COVID-19 and does
not increase the incidence of adverse events.
Advanced Platelet-Rich Fibrin Extract Treatment Promotes the Proliferation
and Differentiation of Human Adipose-Derived Mesenchymal Stem
Cells through Activation of Tryptophan Metabolism
Authors: Lu Guan-Ming , Jiang Li-Yuan , Huang Dong-Lin , Rong Yong-Xian , Li Yang-Hong , Wei Liu-Xing , Ning Yan , Huang Shan-Fu , Mo Steven , Meng Fu-Han , Li Hong-Mian 
Published: December 2021

Background:
Advanced platelet-rich fibrin extract (APRFE) contains a high concentration
of various cytokines that are helpful for improving stem cells repair function. Objective: However,
the underlying mechanism of APRFE improving stem cell repairing is not clear.

Methods:
We produced APRFE by centrifuging fresh peripheral blood samples and isolated and
identified human adipose-derived mesenchymal stem cells (ADMSCs). The abundance of cytokines
contained in APRFE was detected by the Enzyme-linked immunosorbent assay (ELISA).
The ADMSCs treated with or without APRFE were collected for transcriptome sequencing.

Results:
Based on the sequencing data, the expression profiles were contracted. The differentially
expressed genes and lncRNA (DEGs and DElncRNAs) were obtained using for the differential expression
analysis. The lncRNA-miRNA-mRNA network was constructed based on the miRNet
database. The further enrichment analysis results showed that the biological functions were mainly
related to proliferation, differentiation, and cell-cell function. To explore the role of APRFE, the
protein-protein interaction network was constructed among the cytokines included in APRFE and
DEGs. Furthermore, we constructed the global regulatory network based on the RNAInter and TRRUST
database. The pathways in the global regulatory network were considered as the core pathways.
We found that the DEGs in the core pathways were associated with stemness scores.

Conclusion:
In summary, we predicted that APRFE activated three pathways (tryptophan
metabolism, mTOR signaling pathway, and adipocytokine signaling) to promote the proliferation
and differentiation of ADMSCs. The finding may be helpful for guiding the application of ADMSCs
in the clinic.
Mixed Cropping of Dwarf Napiergrass (Pennisetum purpureum cv. Mott) with Indigofera (Indigofera zollingeriana) using an Alley Cropping System
Authors: Utamy Renny Fatmyah , Sonjaya Herry , Ishii Yasuyuki , Hasan Syamsuddin , Nazira Maulina , Taufik Mujtahida , Januarti Etrid 
Published: December 2021

Background:
Mixed cropping of forage grasses and legumes can potentially improve the performance of herbivores. However, the feasibility of grasses mixed-cropped with legumes should be examined at different plant densities.

Aim:
This study aimed to evaluate the growth characters and forage chemical composition in dwarf napiergrass (Pennisetum purpureum cv. Mott) with Indigofera (Indigofera zollingeriana) grown using alley cropping.

Methods:
Three densities of dwarf napiergrass with Indigofera, i.e., high density (2 and 1 plants m-2, respectively); medium density (1.33 and 1 plants m-2, respectively); and low density (1 and 1 plants m-2, respectively) were applied under rainfed conditions in Makassar.

Results:
Plant density significantly affected growth characteristics, such as plant height and tiller density in dwarf napiergrass (p<0.05), and non-significantly affected plant height and branch density (p>0.05) in Indigofera. Plant density did not affect the yielding ability at the first defoliation and annual total of yields (p>0.05), except at the second defoliation when the dry matter production of dwarf napiergrass peaked in the low plant density treatment (p<0.05). In terms of chemical composition, plant density significantly affected fiber concentrations of acid detergent fiber and neutral detergent fiber, which were lowest at low plant densities (p<0.05). The acid detergent lignin and cellulose concentrations tended to be lower at low plant densities, but the differences were not significant (p>0.05).

Conclusion:
We consider that alley cropping systems for dwarf napiergrass and Indigofera are suitable if low plant densities are employed in the region.
Psychological Distress and Coping Strategies among Nurses during the COVID-19 Pandemic: A Cross-Sectional Online Survey
Authors: Alnazly Eman K. , Hjazeen Anees A. 
Published: December 2021

Background:
The emergence of COVID-19 has a significant impact on nurse’s overall health. The severity and magnitude of the COVID-19 pandemic means it is extremely likely that health-care professionals will experience psychological distress as a result of their direct contact with patients who have contracted the infection.

Objectives:
This study aimed to evaluate levels of psychological distress among nurses during the COVID-19 pandemic, determine the associated factors, and identify nurses’ coping strategies.

Methods:
This study is a cross-sectional design. Overall, 130 nurses answered online questionnaires. The questionnaires measured sociodemographic characteristics, Fear of COVID-19 Scale, the Depression, Anxiety, and Stress Scale, and the Brief Coping Inventory.

Results:
Nurses have a moderate level of fear (mean score: 24.34 ± 13.43) and depression (43.8% of the sample), and severe anxiety (73.8%) and stress (45.4%). Anxiety and fear were positively correlated (r = .675, p < .001). Independent t-tests revealed that female nurses had higher psychological distress and fear than male nurses (p = 0.015 and p = 0.038, respectively). Nurses who cared for patients who had tested positive for coronavirus disease 2019 and those who had a friend or family member who had tested positive had higher fear and psychological distress than their respective counterparts (p < .001 and p = .010, respectively). Working more hours was moderately correlated with fear and anxiety (p = 0.016). Nurses were found to generally adopt maladaptive coping styles.

Conclusion:
Through careful study of the factors determined through this research to be associated with psychological distress among nurses, the health-care community can better prepare to mitigate nurses’ emotional and psychological toll in future pandemic situations. Working with patients who have tested positive for COVID-2019 causes psychological distress for nurses.
Undergraduate Nursing Student Perspectives About Challenges in Clinical Education in Jordan: A Cross-Sectional Descriptive Study
Authors: Al-Dweik Ghadeer , Khalil Heba , Atout Maha , Al Zaghmouri Abeer , AbuRuz Mohannad Eid 
Published: December 2021

Introduction:Clinical education is an essential element in a baccalaureate nursing program, providing nursing students with the required knowledge, skills, abilities, and attitudes that are required to deliver professional nursing care after graduation.Objective:The purpose of this study was to identify the student perceived challenges associated with nursing instruction in the clinical environment.Methods:A cross-sectional descriptive design was used to identify the challenges associated with clinical instruction from the nursing students’ perspective. Convenience sampling was used to recruit 187 nursing students from three universities in Jordan, including one public and two private.Results:The major challenges to clinical education were fear of committing mistakes; lack of facilities for students; lack of knowledge among community and patients about the nursing profession; fear of infection; lack of availability of equipment in the clinical setting; students’ lack of preparedness and skills in planning care; and lack of collaboration from clinical staff.Conclusion:Identifying the challenges is necessary to formulate strategies to address them, to improve curriculum designed and clinical education for nursing students accordingly.
This Is the End: Earthquake Narratives and Buddhist Prophesies of Decline
Authors: Childs Geoff , Craig Sienna R. , Juenger Christina , Hildebrandt Kristine 
Published: December 2021

“This Is the End” presents findings from research in which the authors asked survivors of Nepal’s 2015 earthquakes to describe what they know about earthquakes based on their lifelong cultural and environmental experiences, how they responded to the devastating events, and how they view these earthquakes and their aftermath in terms of cause and consequence. The research settings of Tsum, Nubri, Manang, and Mustang were in the midst of rapid socioeconomic transformations and environmental disruptions when the earthquakes struck. Interviews shortly after the event reveal that many people are familiar with scientific concepts like the movement of tectonic plates, yet they attribute the earthquake’s ultimate cause to human activities that disturb autochthonous deities. Their interpretations suggest parallels with signs of impending doom contained within written prophesies, including a decline in religious devotion, the fraying of social cohesion, and environmental disruptions. The linking of written prophesies with lived experiences points toward a Buddhist understanding of conventional and ultimate realities in which people discuss the material and geophysical causes and consequences of earthquakes while also considering moral and cosmological understandings stemming from socially and environmentally destructive behaviors. This article contributes to a growing literature on the intersections of religion and natural disasters.
Our Land, Our People: A Reflection of Tibetan Buddhist Space in Contemporary Art
Authors: Daugherty Jay 
Published: December 2021

This article illustrates how a contemporary Tibetan artist disrupts expectations in the creation of his political art. Utilizing Robert Smithson’s dialogic of site and non-site, Tenzing Rigdol’s 2011 site-specific installation Our Land, Our People is interpreted as a reenactment of a culturally specific historical practice of moving space. This approach shares important similarities to historical cases in which physical spaces were relocated to and within Tibet, allowing for the application of 20th century theories arising in the spatial turn to contemporary Tibetan art.
Beyond the (Dis)Empowerment Binary: Inevitability and the Feminization of Agriculture in Chitwan, Nepal
Authors: Kellogg Naomi Jade , Andersen Anton Boesgaard , Biraschi Rebecca , Puri Susmita 
Published: December 2021

Changing demands of the agricultural sector, due to male out-migration, have been shown to influence power dynamics and livelihood strategies within households, communities, and broader society. These shifts have led to a rise in women’s agricultural engagement in Nepal. In hypothesizing the outcomes of what has been defined as the feminization of agriculture on the women left behind, the existing literature has created a (dis)empowerment binary. Based on field work conducted in Chitwan, we initially confirm that women do experience that increased agricultural engagement presents both the potential for an increased burden and an opportunity for empowerment. Our research then goes beyond this binary, by utilizing the concept of inevitability, revealing both the micro and macro level nexi of migration, agriculture, and gender in relation to the feminization of agriculture in Nepal. By underscoring the double inevitability of both male out-migration itself and women’s roles within their households we argue we can more accurately represent our informants’ lived realities and thereby provide an alternative to the (dis)empowerment binary for future research. This includes the recognition of a relational nature of the feminization of agriculture phenomenon, which is often overlooked in the current discourse.
AS DIFERENTES LINGUAGENS DA CRIANÇA NA CRECHE:
Authors: Bortolanza Ana Maria Esteves , Oening Letícia Cardozo 
Published: December 2021

Este artigo analisa, a partir das narrativas escritas por uma professora de creche, as diferentes linguagens pelas quais se expressam as crianças de 3 anos e suas relações com o desenvolvimento infantil na primeira infância. Caracteriza-se como pesquisa qualitativa (2019-2020), de caráter exploratório, tendo como instrumento de investigação duas narrativas escritas por uma professora de uma creche da rede de Educação Infantil de Tubarão (SC). A pesquisa baseou-se em estudos na perspectiva histórico-cultural e em autores que discutem a infância, as linguagens da criança e o desenvolvimento infantil. Os resultados evidenciaram que as diferentes linguagens da criança parecem pouco experenciadas na creche, não se estabelecendo relação entre elas e o desenvolvimento infantil. Conclui-se que para o desenvolvimento pleno da criança, na primeira infância, as linguagens precisam ser trabalhadas em suas especificidades, de acordo com suas necessidades, e respeitando suas singularidades. A escola de Educação Infantil, por meio de atividades intencionalmente planejadas, deve garantir as diferentes linguagens como mediadoras da criança no processo de conhecer o mundo, o outro e a si mesma, condições para seu desenvolvimento.