bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Neural Network Model Using Immune-infiltration Modules for Endometrial Receptivity Assessment of Implantation Failure
Authors: Li Bohan , Duan Hua , Wang Sha , Wu Jiajing , Li Yazhu 
Published: September 2021

Abstract
ObjectivesThis study was anchored on the state of local immune-infiltration in the endometrium, which acts as critical factors affecting embryonic implantation, and aimed at establishing novel approaches to assess endometrial receptivity for patients with IVF failure.MethodsImmune-infiltration levels in the GSE58144 dataset (n=115) from GEO were analyzed by digital deconvolution and validated by immunofluorescence (n=30), illustrating that dysregulation of the ratio of Mf1 to Mf2 is an important factor contributing to implantation failure. Then, modules most associated with M1/M2 macrophages (Mfs) and their hub genes were then selected by weighted gene co-expression network and univariate analyses, then validated by GSE5099 macrophage dataset, qPCR analysis (n=16), and western blot. It revealed that closely related gene modules dominated three biological processes in macrophages: antigen presentation, interleukin−1−mediated signalling pathway, and phagosome acidification, respectively. Their hub genes were significantly altered in patients and related with ribosomal, lysosome, and proteasomal pathways. Finally, the artificial neural network (ANN) and nomogram models were established from hub genes, of which efficacy was compared and validated in the GSE165004 dataset (n=72). Models established by the selected hub genes exhibited excellent predictive values in both datasets, and ANN performed best with an accuracy of 98.3% and an AUC of 0.975 (95% CI 0.945-1). ConclusionsMacrophages, proven to be essential for endometrial receptivity, were regulated by gene modules dominating antigen presentation, interleukin−1−mediated signalling pathway, and phagosome acidification. Selected hub genes can effectively assess endometrial dysfunction receptivity for IVF outcomes by the ANN approach.
Evaluation of Physical Properties of Mycelium-Based Bio Composites for Use As Facade Insulation Material
Authors: Dehn Frank , Kotan Engin 
Published: September 2021

Abstract
Background: To evaluate the usability of mycelium-based materials for construction, first tests were carried out to determine their suitability for thermal insulation. Different substrate compositions were tested for various physical properties. The compositions and experimental setups used are described in the “Methods” section. Results: Materials based on fungal mycelium were found to have promising properties for use in the construction sector. Their thermal conductivities are comparable to those of commercially available ecological insulation materials. As material properties turned out to be dependent on the substrate used for the production of mycelium materials, further optimisation is required. Conclusion: For first preliminary tests [1] to study the performance of mycelium-based materials, different additives (beech wood, rice husks, coffee silver skin, perlite rock) were added to a base substrate to determine their influence on physical properties. Compared to the characteristics of conventional thermal insulation materials, the test results obtained are rather promising and confirm suitability of mycelium-based materials for building. However, further systematic studies are needed to investigate options to improve major properties and to ensure reproducibility of mycelium materials with largely homogeneous properties.
Engaging MSM Communities in HIV Self-Testing Research and Programming in Kenya: Collaborations, Tacit Knowledge, and a Community-Based Programme Science Approach
Authors: Kombo Bernadette Kina , Thomann Matthew , Lazarus Lisa , Musyoki Helgar , Olango Kennedy , Kuria Samuel , Kyana Martin , Otieno Memory , Njiriani Margaret , Musimbi Janet , Bhattacharjee Parinita , Lorway Robert 
Published: September 2021

Abstract
Background: Understanding the basic principles for achieving research outcomes that are relevant to local communities is invaluable. The process allows for building of collaborative spaces and redistribution of power in knowledge production practices. This is because members of marginalized and vulnerable communities have long been critical of a research culture that has historically failed to advance meaningful collaboration and overlooks local forms of knowledge at various phases of the research processes. There has however not been a clear framework that outlines how communities should be meaningfully engaged. Rather, substantial variations in the nature of community engagements exist across research projects, thus requiring a more nuanced approach of working with communities. Methods: In this methodological paper, we describe how a community-based program science approach guided an interdisciplinary research project to inform the rollout of HIV self-testing (HIVST) among men who have sex with men (MSM) in three urban counties in Kenya. Community members and their research and programmatic partners collaborated through all phases of the research process including research design, data collection, and translation of research. Importantly, community researchers and policy makers also played an integral role in data analysis, going well beyond the conventional role of “community engagement” in global health research. Results: The study created a platform that enabled meaningful collaborations across the diverse stakeholders and allowed the MSM communities to contribute to the decisions and solutions impacting on their community. Our community-based program science approach recognizes that community researchers possess tacit knowledge, a form of expertise that formally trained researchers do not have. Conclusion: We argue that in order to fully engage with such expertise, marginalized communities must be meaningfully involved in all levels of evidence building and decision making around programs impacting their communities. We equally emphasize the importance of setting up operating norms and clear definitions of partnership roles at the initial stages of establishing collaborations. Such a move gives the community a chance to trust their capabilities and contribute more meaningfully throughout the research processes.
Gender Difference in the Incidence of Malaria Diagnosed at Public Health Facilities in Uganda
Authors: Okiring Jaffer , Epstein Adrienne , Namuganga Jane F. , Kamya Emmanuel V. , Nabende Isaiah , Nassali Martha , Sserwanga Asadu , Gonahasa Samuel , Muwema Mercy , Kiwuwa Steven M. , Staedke Sarah G. , Kamya Moses R. , Nankabirwa Joaniter I. , Briggs Jessica , Jagannathan Prasanna , Dorsey Grant 
Published: September 2021

Abstract
BackgroundRoutine malaria surveillance data in Africa primarily come from public health facilities reporting to national health management information systems. Although information on gender is routinely collected from patients presenting to these health facilities, stratification of malaria surveillance data by gender is rarely done. This study evaluated gender difference among patients diagnosed with laboratory confirmed malaria at public health facilities in Uganda.MethodsThis study utilized individual level patient data collected from January 2020 through April 2021 at 12 public health facilities in Uganda and cross-sectional surveys conducted in target areas around these facilities in April 2021. Associations between gender and the incidence of malaria and non-malarial visits captured at the health facilities from patients residing within the target areas were estimated using poisson regression models controlling for seasonality. Associations between gender and data on health seeking behaviour from the cross-sectional surveys were estimated using poisson regression models controlling for seasonality. ResultsOverall, incidence of malaria diagnosed per 1000 person years was 735 among females and 449 among males (IRR=1.72, 95% CI 1.68-1.77, p<0.001), with larger differences among those 15-39 years (IRR=2.46, 95% CI 2.34-2.58, p<0.001) and over 39 years (IRR=2.26, 95% CI 2.05-2.50, p<0.001) compared to those under 15 years (IRR=1.46, 95% CI 1.41-1.50, p<0.001). Female gender was also associated with a higher incidence of visits where malaria was not suspected (IRR=1.77, 95% CI 1.71-1.83, p<0.001), with a similar pattern across age strata. These associations were consistent across the 12 individual health centres. From the cross-sectional surveys, females were more likely than males to report fever in the past 2 weeks and seek care at the local health centre (7.5% vs 4.7%, p=0.001) with these associations significant for those 15-39 years (RR=2.49, 95% CI 1.17-5.31, p=0.018) and over 39 years (RR=2.56, 95% CI 1.00-6.54, p=0.049). ConclusionsFemales disproportionately contribute to the burden of malaria diagnosed at public health facilities in Uganda, especially once they reach childbearing age. Contributing factors included more frequent visits to these facilities independent of malaria and a higher reported risk of seeking care at these facilites for febrile illnesses.
Study of The Effect of TiO2 Addition On The Crystalline Phases, Structure and Chemical Durability of a Nuclear Glass Ceramic
Authors: SOUAG Rafika , KAMEL Nour elhayet , Moudir Dalila , MOUHEB Yasmina , Aouchiche Fayrouz 
Published: September 2021

Abstract
This study focused on the effect of TiO 2 addition on the crystallines phases’ formation, structure and chemical durability of a nuclear glass ceramic constituted by an aluminosilicate glass in the system: SiO2-Al2O3-CaO-MgO-ZrO2-TiO2 . The materials with four contents of TiO2 , ranging from 4.11 to 7.11 wt.%, are synthesized by a discontinuous method,. For the whole of materials, X-ray diffraction analysis allow identifying an aluminosilicate belonging to pyroxenes silicates family as a main phase, powelite and calzirtite. Both SEM and DTAanalyses confirmed these results. The materials FTIR analysis reveals the glass ceramics complex chemical composition. MCC1 and MCC2 tests, performed on selected glass ceramic materials, indicate that the materials with 4.11 and 5.11 wt.% TiO2 are the most durable against Si, Al, Mg and Ce elements release, in MCC2 test; The results make conclusions valuable on the selection of such glass ceramics as candidate for the disposal of high-level waste.
Utility of Indocyanine Green Videoangiography with FLOW 800 Analysis in Brain Tumor Resection - Venous Protection Technique
Authors: Sun Yue , Wang Zilan , Jiang Fan , Yang Xingyu , Xin Tan , Chen Zhouqing , Liu Yanfei , Zhu Yun , Wang Zhong , Chen Gang 
Published: September 2021

Abstract
Background: When it comes to central nervous system tumor resection, preserving vital venous structures to avoid devastating consequences such as brain edema and hemorrhage is important. Wheras, in clinical practice, it is difficult to obtain clear and vivid intraoperative venous visualization and blood flow analysis.Methods: We presented our clinical cases to demonstrate the process of venous preservation during surgical resection through the application of indocyanine green videoangiography (ICG-VA) integrated with FLOW 800. Galen vein, sylvian vein and superior cerebral veins of the brain were included.Results: Clear documentations of the veins from different venous groups were obtained via ICG-VA integrated with FLOW 800, which semiquantitatively analyzed the flow dynamics. ICG-VA integrated with FLOW 800 enabled us to achieve brain tumor resection without venous injury and obstructing the venous flux.Conclusions: ICG-VA integrated with FLOW 800 is an efficient method for venous preservation, though further comparison between ICG-VA integrated with FLOW 800 and other techniques of intraoperative blood flow monitoring is needed.
Performance evaluation in the reconstruction of 2D images of computed tomography using massively parallel programming CUDA
Authors: Cordeiro Alexssandro Ferreira , Filho Pedro Luiz de Paula , Silva Hamilton Pereira , Junior Arnaldo Candido , Casanova Edresson , Spancerski Jandrei Sartori 
Published: September 2021

Abstract
Purpose: analysis of processing time and similarity of images generated between CPU and GPU architectures and sequential and parallel programming methodologies.

Material and methods: for image processing a computer with AMD FX-8350 processor and an Nvidia GTX 960 Maxwell GPU was used, along with the CUDAFY library and the programming language C# with the IDE Visual studio.

Results: the results of the comparisons indicate that the form of sequential programming in a CPU generates reliable images at a high custom of time when compared to the forms of parallel programming in CPU and GPU. While parallel programming generates faster results, but with increased noise in the reconstructed image. For data types float a GPU obtained best result with average time equivalent to 1/3 of the processor, however the data is of type double the parallel CPU approach obtained the best performance.

Conclusion: for the float data type, the GPU had the best average time performance, while for the double data type the best average time performance was for the parallel approach CPU. Regarding image quality, the sequential approach obtained similar outputs, while theparallel approaches generated noise in their outputs.
Relationship Between Insulin Resistance and Serum Androgens Levels in Women With and Without PCOS by Rotterdam Diagnosis Criteria
Authors: Movahedinejad Maryam , Ziaei Saeide , Kazemnezhad Anooshiravan , kamali zahra 
Published: September 2021

Abstract
IntroductionPCOS is the most common endocrine disorder in women of childbearing age. Insulin resistance is a key component of the pathophysiology of PCOS that can increase the secretion of serum androgens. The aim of this study was to determine the relationship between insulin resistance and serum androgens levels in PCOS subgroups.MethodsHormonal and clinical laboratory studies were performed for all research units. Insulin resistance was diagnosed with the HOMA index (Cut off> 2.5). ResultsIn subgroup A, there was a positive relationship between HOMA-IR with FAI (P = 0.014) and negative relationship with SHBG (P <0.001). In subgroup C, a negative relationship was observed between HOMA-IR and SHBG (P = 0.002). In subgroup D, there was a positive relationship between HOMA-IR and FAI (P = 0.035). No significant association was found in the control group and subgroup B (P> 0.05). Also, in all different PCOS phenotypes, no association was found between HOMA-IR and serum TT levels (P> 0.05).ConclusionThere was a relationship between insulin resistance and some serum androgens in PCOS subtypes. Therefore, it is hoped that early detection of these at-risk patients will be done through early biochemical markers to prevent and change lifestyle.
Differentially Expressed Circular RNAs in Stenosed Arteriovenous Fistula Tissues of Uremia Patients
Authors: Lan Lili , Liu Yu , Zou Menglin , Xie Yihang , Zhang Yiye , Tian Liqing , Xiao Jun , Yang Liu , Zhang Li , Yan Yan 
Published: September 2021

Abstract
BackgroundArteriovenous fistula (AVF) is the most common renal replacement therapy for uremic patients. However, stenosis in AVF may lead to AVF failure, hence prevention and effective management of AVF failure is an issue to be addressed. circular RNAs (circRNAs) dysregulation may be pivotal for the development and progression of AVF stenosis. MethodsFour stenosed tissues from AVF outflow veins and four normal venous tissues without vascular stenosis were collected for RNA-sequencing (RNA-seq). The circRNAs expression profiles were identified by high-throughput sequencing, and the functions and pathways of differentially expressed (DE) circRNAs were annotated by Gene Ontology (GO) and Kyoto Encyclopedia of Gene Genomes (KEGG) enrichment analyses. Seven DE circRNAs were screened for quantitative real‐time polymerase chain reaction (qRT-PCR) validation. circRNA-miRNA interaction network was constructed. ResultsA total of 17,620 circRNA transcripts were examined by RNA-seq, and 208 DE circrRNAs were identified between AG and CG, of which 92 were upregulated and 116 were downregulated. The expression trend in the four selected circRNAs was validated by qRT-PCR, which was consistent with the RNA-seq results. Dysregulated circRNAs may be involved in stenosis by mediating focal adhesion kinase (FAK) pathway. Conclusion﻿Our study revealed abnormal circRNA expression in stenosed tissues of the AVF outflow vein, which was functionally classified. The results indicated that DE circRNAs in the stenosed tissues of AVF and their related FAK pathway have potential to be targets for the prevention and treatment of AVF failure.
Effect of Dietary Zinc Supplementation on the Gastrointestinal Microbiota and Host Gene Expression in the Shank3B-/- Mouse Model of Autism Spectrum Disorder
Authors: Wong Giselle C , Jung Yewon , Lee Kevin , Fourie Chantelle , Handley Kim M. , Montgomery Johanna M , Taylor Michael W. 
Published: September 2021

Abstract
Background: Shank genes are implicated in ~1% of people with autism and mice with Shank3 knock out mutations exhibit autism-like behaviours. Zinc deficiency and gastrointestinal problems can be common among people with autism, and zinc is a key element required for SHANK protein function and gut development. In Shank3B-/- mice, a supplementary zinc diet reverses autism behaviours. We hypothesise that dietary zinc may alter the gut microbiome, potentially affecting the gut-microbiota-brain axis, which may contribute to changes in autism-like behaviours. Methods: Four types of gastrointestinal samples (ileum, caecum, colon, faecal) were collected from wild-type and knock-out Shank3B-/- mice on either control or supplemented-zinc diets. Bacterial 16S rRNA gene and fungal ITS2 genomic region amplicons were sequenced on the Illumina MiSeq platform and RNA on the Illumina HiSeq platform.Results: Cage, genotype and zinc diet each contributed significantly to bacterial community variation (accounting for 12.8%, 3.9% and 2.3% of the variation, respectively). Fungal diversity differed significantly between wild-type and knock-out Shank3B-/- mice on the control zinc diet, and the fungal biota differed among gut locations. RNA-seq analysis of host (mouse) transcripts revealed differential expression of genes involved in host metabolism that may be regulated by the gut microbiota and genes involved in anti-microbial interactions. Limitations: This study used the Shank3B-/- mouse model of autism spectrum disorder. Heterozygous and homozygous Shank3 gene mutations are found in 1% of the ASD population, only homozygous Shank3 mice were utilised in this study. Any translational conclusions should consider these limitations.Conclusions: By utilising the Shank3B-/- knock-out mouse model we were able to examine the influence of – and interactions between – dietary zinc and ASD-linked host genotype. Differential expression of host antimicrobial interaction genes as well as gut microbiota-regulated host metabolism genes among the treatment groups, suggests that the interplay between gut microbes, the gastrointestinal tract and the brain may play a major role towards the observed amelioration of ASD behaviours seen previously with supplemented dietary zinc. These data broaden understanding of the gut microbiome in autism and pave the way towards potential microbial therapeutics for gastrointestinal problems in people with autism.
Short-Term Effects of Ambient Air Pollution On Daily Emergency Room Visits for Abdominal Pain: A Time-Series Study in Wuhan, China
Authors: Liu Yaqi , Jiang Yi , Wu Manyi , Muheyat Sunghar , Yao Dongai , Jin Xiaoqing 
Published: September 2021

Abstract
Background

There are few studies focused on the correlations between ambient air pollution and abdominal pain, especially in emergency departments in China.
Method:

Daily data (from January 1, 2016 to December 31, 2018), including air pollution concentration (SO2, NO2, PM2.5, PM10, CO, and O3) and meteorological variables, for daily emergency room visits (ERVs) were collected in Wuhan, China. We conducted a time-series study to investigate the potential correlation between six ambient air pollutants and ERVs for abdominal pain and their effects, in different genders, ages and seasons.
Results

A total of 16,306 abdominal pain ERVs were identified during the study period. A 10-µg/m3 increase in concentration of SO2, NO2, PM2.5, PM10, CO, and O3 corresponded respectively to incremental increases in abdominal pain of 6.12% (95% confidence interval [CI]: -0.44-13.12), 1.65% (95%CI: -0.25-3.59), 1.12% (95%CI: -0.18-2.44), 0.38% (95%CI: -1.09-1.87), 9.87% (95%CI:3.14–17.05) and 1.11% (95%CI: 0.03–2.21). We observed significant correlations between CO and O3 and daily abdominal pain ERVs increase, and positive but insignificant correlations between the other pollutants and ERVs. The effects were stronger mainly for females (especially SO2 and O3) and younger people (especially CO and O3). The correlations of PM2.5 and PM10 were stronger in cool seasons, while the correlation of CO was stronger in warm seasons.
Conclusion

Our time-series study suggested that short-term exposure to air pollution (especially CO and O3) was positively correlated with ERVs for abdominal pain in Wuhan, China, and that their effects varied by season, gender and age. These data can add evidence on how air pollutants affect the human body, and may prompt hospitals to take specific precautions on polluted days and maintain order in emergency departments made busier due to the pollution.
Design Optimization of Nanotube Tunnel Field-Effect Transistor with Bias-Induced Electron-Hole Bilayer
Authors: Wang Xueke , Sun Yabin , Liu Ziyu , Liu Yun , Li Xiaojin , Shi Yanling 
Published: September 2021

Abstract
In this paper, a novel nanotube tunneling field-effect transistor (NT-TFET) with bias-induced electron-hole bilayer (EHBNT-TFET) is proposed for the first time. By the intentional misalignment and an asymmetric bias configuration of the inner-gate and outer-gate, the line tunneling takes place inside the channel, significantly improving the tunneling rate and area. The device principle and performance are investigated by calibrated 3-D TCAD simulations. Compared to the conventional NT-TFET, the proposed EHBNT-TFET exhibits an increased ON-state current (ION) about 57.2 times and a sub-60 mV/dec subthreshold swing for seven orders of magnitude of drain current. Furthermore, the increased ION and reduced gate capacitance achieve improved dynamic performance. Compared with conventional NT-TFET, the intrinsic delay decreased about 142 times is obtained in EHBNT-TFET.