bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONHECIMENTOS E PRÁTICAS DE SAÚDE BUCAL POR PACIENTES INTERNADOS E EQUIPE HOSPITALAR
Authors: Fernandes Anderson de Souza , Emiliano Gustavo Barbalho Guedes , Martins Ana Rafaela Luz de Aquino , Souza Georgia Costa de Araújo 
Published: December 2021

Introdução: Indivíduos hospitalizados mantêm maior atenção para as doenças de base. Logo, negligenciam outros cuidados como a higiene bucal. Não obstante, a equipe hospitalar multidisciplinar, na ausência do cirurgião-dentista, em geral não se considera responsável pelos cuidados bucais dos pacientes. Objetivo: Identificar os conhecimentos e práticas de saúde bucal dos pacientes internados, além de analisar as ações de promoção e prevenção em saúde bucal prestadas pelos profissionais de um Hospital de referência para a Região do Seridó, Rio Grande do Norte. Metodologia: Trata-se de uma pesquisa de caráter exploratório e transversal, realizada com 166 pacientes e 50 profissionais da equipe hospitalar. Utilizou-se de entrevistas semiestruturadas como instrumento de coleta de dados. Resultados: No período da internação hospitalar, 85,5% (n=142) dos pacientes estavam com escova e creme dental, porém 15,7% (n=26) não escovaram os dentes e 18,1% (n=30) escovaram apenas uma vez em todo o período da internação. O fio dental não foi utilizado por 97,6% (n=162) dos entrevistados. Ademais, 97,6% (n=162) dos pacientes não receberam quaisquer orientações de saúde bucal pelos profissionais. Por outro lado, 58,0% (n=29) da equipe hospitalar consideram seus conhecimentos sobre saúde bucal insatisfatórios. Conclusões: É fato que alguns pacientes negligenciam os hábitos de higiene bucal, além de não ser rotina dos profissionais cuidar da saúde bucal dos enfermos. Com isso, percebe-se o quão importante é a atuação do cirurgião-dentista no âmbito hospitalar.
ADESÃO DAS MULHERES AO EXAME CITOPATOLÓGICO PARA PREVENÇÃO DO CÂNCER CERVICOUTERINO
Authors: Silva Alexandre Bezerra , Rodrigues Maísa Paulino , Medeiros Júnior Antônio , Oliveira Amanda Paulino de , Melo Ricardo Henrique Vieira de 
Published: December 2021

Objetivo: Analisou-se os motivos, na visão dos enfermeiros, os quais levam as mulheres a realizarem o exame de prevenção contra o câncer cervicouterino em um município do Rio Grande do Norte. Métodos: Foi realizado um estudo com abordagem qualitativa, junto a 11 enfermeiros das equipes da Estratégia de Saúde da Família do município de Assú/RN. O material coletado, através de entrevistas abertas, foi submetido à análise de conteúdo temático proposta por Bardin. As falas produziram duas categorias de análise: motivos que levam a realização do exame e atitudes/situações de risco que contribuem para o câncer cervicouterino. Resultados: A procura para a realização do exame contra o câncer do colo do útero é praticada por razões diversas, revelando pouco conhecimento das mulheres sobre o objetivo do referido exame. Conclusões: Os resultados apontam que o desconhecimento das mulheres sobre o câncer do colo do útero é um fator que contribui, de forma significativa, para o aumento dos casos de câncer cervicouterino. As mulheres procuram realizar o exame contra o câncer cervicouterino, quando apresentam sintomas como corrimento vaginal, prurido vaginal e aguardam o aparecimento desses e outros sintomas para a realização do exame contra o câncer cervicouterino.
Entre o rio e a comunidade
Authors: De Farias Panet Miriam , Tejo Bruna , Luna Matheus 
Published: December 2021

O processo projetual que obteve como produto final o anteprojeto de uma Unidade Básica de Saúde, localizada na cidade de Belém (PA), foi resultado de uma experiência acadêmica de interdisciplinaridade e colaboração mútua com os alunos do quarto período do curso de Arquitetura e Urbanismo da Universidade Federal de Campina Grande – CAU/UFCG, a partir da integração entre as disciplinas de Projeto de Arquitetura II (PA II), Planejamento da Paisagem I (PP I) e Conforto Ambiental II (CA II). As metodologias aplicadas às disciplinas, como: avaliação pós ocupação (APO), estudo de projetos correlatos e a consultoria de especialistas - contribuíram não apenas para a concepção projetual, como, também, para o incentivo do senso crítico e questionador acerca do espaço e de suas respectivas apropriações. Ao final do processo foram selecionadas três propostas para representar o CAU/UFCG no concurso estudantil íbero-americano de arquitetura bioclimática na XI Bienal José Miguel Aroztegui, que ocorreu durante o ENCAC/ELACAC na cidade de João Pessoa/PB. O anteprojeto da Unidade Básica de Saúde intitulada “UBS Rio Guamá” foi selecionado como menção honrosa
Proteomic Analysis of Early Phosphorylated Proteins in Acute Pancreatitis
Model
Authors: Xiao Juan , Zhang Pengcheng , Zhou Yuan , Fang Qiangqiang , Lin Houmin 
Published: December 2021

Background and Objective:
The exact mechanism of acute pancreatitis (AP), which is an inflammation of the pancreas, still remains unclear. In this study, we examined the protein phosphorylation changes during the early stage of AP in mice using proteomic analysis.

Methods:
AP model in mice was constructed using an intraperitoneal injection of cerulein. Blood samples and pancreas were collected at 1, 3, 6, 9h after the final injection (n=3 at each time point). Samples collected 3h after the final injection were separately mixed and named S (saline group) and C1 (cerulein group); samples collected 6h after the final injection from the cerulein group were mixed and named C2. Proteins from S, C1, and C2 were extracted, digested by trypsin, and subjected to LC-MS/MS analysis, bioinformatics analysis, and Western blotting.

Results:
A total of 549 sites (426 proteins) were upregulated, and 501 sites (367 proteins) were downregulated in C1 compared to S; while 491 phosphorylation sites (377 proteins) were upregulated and 367 sites (274 proteins) were downregulated in C2 compared to S. Motif analysis showed that proline-directed kinase and basophilic kinase had a key role during early AP. During an early AP stage, the cellular distributions of proteins slightly changed. The types of domains changed with the development of AP. Phosphorylation proteins associated with calcium signaling, especially IP3R mediated calcium release, lysosome and autophagosome pathway, pancreatic digestive activation, and secretion, were found to be involved in the development of early AP independent of NF-kB activation. Moreover, the MAPK family was found to have a greater impact at the early stage of AP. We also found differentially expressed phosphorylations of amylase and trypsinogen and increased phosphorylation of MAPK6 S189 in early AP.

Conclusion:
IP3R mediated calcium release and activation of MAPK family are key events promoting the development of early AP.
Functional Disability among Systemic Sclerosis Patients: Relation to Disease
Characteristics and Quality of Life Parameters
Authors: Zaghlol Rabab S. , Dawa Ghada A. , Makarm Wafaa K. 
Published: December 2021

Background:
Disability in patients with scleroderma (SSc) has been associated with
poor health-related quality of life (HRQoL) in all dimensions, including physical, psychological,
and social dimensions.

Objective:
This study was conducted to examine different factors that may be associated with functional
disability and poor HRQoL, with the aim of targeting these factors in the future to improve
physical activity, functional outcomes, and HRQoL.

Methods:
A single-center cross-sectional study was conducted on 38 patients with SSc to compare
characteristics between patients with and without disability using the Health Assessment Questionnaire
Disability Index (HAQ-DI). Quality of life was assessed using the Short Form-36 (SF-36).
Linear regressions were performed to examine variables contributing to functional disability.

Results:
Almost 65.78% (n = 25) of patients in the study group reported functional disability. The
presence of functional disability was associated with reduced HRQoL, as reflected by physical
function (P = 0.0001), physical role (P = 0.016), bodily pain (P = 0.001), general health
(P = 0.002), social functional (P = 0.002), emotional role (P = 0.042), and mental health (P = 0.025)
domains of the SF-36 score. Multiple linear regression indicated that the main predictive factors associated
with HAQ-DI were the modified Hand Mobility in Scleroderma, modified Rodnan skin
score, DIstance walked in 6 minutes, BOrg dyspnea index, and SAturation of oxygen at 6 minutes
(DIBOSA), and Fatigue Severity Scale among patients with SSc.

Conclusion:
In patients with SSc, recognizing the relationships between clinical findings and functional
disability will allow the development of further management strategies to minimize disease
severity and enhance HRQoL.
Type I Diabetes Mellitus and Insulin Therapy on Bone Microarchitecture,
Composition and Mechanical Properties
Authors: Dechichi Paula , Limirio Pedro Henrique Justino Oliveira , Soares Priscilla Barbosa Ferreira , Venâncio Jessyca Figueira , Rabelo Gustavo Davi , Soares Carlos José 
Published: December 2021

Background:
The aim of this study was to evaluate the microarchitecture, composition
and mechanical properties of cortical bone of rats with type I diabetes mellitus (TIDM) and submitted
to insulin therapy (IT).

Methods:
Thirty rats were divided into three groups (n=10): non-diabetic, diabetic and diabetic+insulin.
TIDM was induced by intravenous injection of streptozotocin. In diabetic+insulin group, 4IU
insulin was administered twice per day (1I U at 7 am and 3I U at 7 pm). The animals were euthanized
five weeks after TIDM induction; the tibiae were removed and submitted to microcomputed
tomography (micro-CT, 8 μm), fourier transform infrared spectroscopy (FTIR) and dynamic microhardness
indentation.

Results:
Micro-CT analysis showed that diabetic group had lower bone surface/tissue volume ratio
(BS/BV) (p=0.018), cortical thickness (Ct.Th) (p<0.001) and degree of anisotropy (Ct.DA)
(p=0.034) values compared to non-diabetic group. The diabetic group showed lower Ct.Th than diabetic
+ insulin group (p=0.018). The non-diabetic group had lower fractal dimension (Ct.FD) values
compared to diabetic groups (p<0.001). The ATR-FTIR analyses showed lower values for all
measured parameters in the diabetic group than the non-diabetic group (amide I ratio: p=0.046;
crystallinity index: p=0.038; matrix:mineral ratios - M:MI: p=0.006; M:MIII: p=0.028). The diabetic+
insulin group showed a lower crystallinity index (p=0.022) and M:MI ratio (p=0.002) than nondiabetic
and diabetic groups, respectively. The diabetic group showed lower Vickers hardness values
than non-diabetic (p<0.001) and diabetic+insulin (p=0.003) groups.

Conclusion:
TIDM negatively affects bone microarchitecture, collagen maturation, mineralization
and bone microhardness. Moreover, insulin minimized the effect of TIDM on cortical thickness
and organic/mineral matrix.
Current Research on Pro-drug Therapies for Parkinson's and Alzheimer's Disease
Authors: Huo Cui , Wu Lei , Jiang Zhiqiang , Yang Jiacheng , Wang Zhouyu , Li Yuzhi , Qian Shan 
Published: December 2021

Background:
Alzheimer's disease (AD) and Parkinson's (PD) disease are common neurodegenerative
conditions of the Central Nervous System (CNS). Thus, these diseases have only been
treated symptomatically since no approved drug is available that provides a complete cure.

Objectives:
Through reading relevant literatures published at home and abroad, the method and significance
of prodrug strategy to increase the efficacy of ad and pd drugs were discussed.

Methods:
The biological mechanisms and currently approved drugs for both diseases have been discussed,
revealing that most of these treatments utilized existing prodrug design strategies, including
increased lipophilicity, and the use of transporters mediation and bio-oxidation to improve oral bioavailability
and brain permeability.

Results:
The purpose of this paper is to review the research progress in the treatment of Neurodegenerative
Diseases (NDDS), especially ad and pd, using the prodrug strategy. The research of drug
bioavailability and the prodrug strategy of cns targeted drug delivery lay the foundation for drug
development to treat these diseases.

Conclusion:
The use of prodrug strategies provides important opportunities for the development of
novel therapies for ad and pd.
Diabetes Induced Factors Prediction Based on Various Improved Machine
Learning Methods
Authors: Wu Jun , Qu Lulu , Yang Guoping , Han Nan 
Published: December 2021

Background:
With the increasing quality of life of people, people have begun to have more
time and energy to pay attention to their own health problems. Among them, diabetes, as one of the
most common and fastest-growing diseases, has attracted widespread attention from experts in bioinformatics.
People of different ages all over the world suffer from diabetes, which can shorten the life
span of patients. Diabetes has a significant impact on human health, so that the accuracy of the initial
diagnosis becomes essential. Diabetes can bring some serious complications, especially in the elderly,
such as cardiovascular and cerebrovascular diseases, stroke, and multiple organ damage. The initial diagnosis
of diabetes can reduce the possibility of deterioration. Identifying and analyzing potential risk
factors for different physical attributes can help diagnose the prevalence of diabetes. The more accurate
the prevalence, the more likely it is to reduce the incidence of complications.

Methods:
In this paper, we use the open source NHANES data set to analyze and determine potential
risk factors relevant to diabetes by an improved version of Logistic Regression, SVM, and other improved
machine learning algorithms.

Results:
Experimental results show that the improved version of Random Forest has the best effect,
with a classification accuracy of 92%, and it can be found that age, blood-related diabetes, high blood
pressure, cholesterol and BMI are the most important risk factors related to diabetes.

Conclusion:
Through the proposed method of machine learning, we can cope with class imbalance and
outlier detection problems.
Elements That Underpin the Design, Development, and Evaluation of Social Media Health Interventions: Protocol for a Scoping Review
Authors: Nizam Mohammed Zayan , Powell Leigh , Zary Nabil 
Published: December 2021

Background
Social media use has grown tremendously over the years. Given the volume and diversity of people on social media and the amount of information being exchanged, it is perhaps unsurprising that social media is being used as an avenue to disseminate and deliver health interventions. There exists an opportunity for social media health interventions to make a positive impact on health. However, there is a need to understand more about the ways in which these interventions are designed, developed, and evaluated. This scoping protocol will review the current state of this field by charting the elements that drive the design, development, and evaluation of these interventions. This includes charting models, frameworks, and rationales for the interventions, as well as the platforms being used, and the health behaviors being targeted. This intention of this scoping review is to help inform those who wish to develop effective social media health interventions.

Objective
The objective of this review is to map the elements that drive the design, development, and evaluation of social media health interventions. We define “social media health intervention” as interventions that make use of social media platforms to disseminate or deliver health-related information and educational initiatives to the public. We will seek to chart the elements that drive the design, development, and delivery of such interventions, including their platforms and targeted health behaviors.

Methods
The methodological framework for this review is guided by Arksey and O’Malley and enhancements by later studies. We will search relevant literature from 9 databases: (1) PubMed, (2) PsycINFO, (3) EMBASE, (4) Web of Science, (5) Scopus, (6) CINAHL, (7) ERIC, (8) MEDLINE, and (9) Google Scholar. The literature will be screened by at least two reviewers in 2 stages: (1) title/abstract screening against the eligibility criteria; and (2) eligible articles will then undergo a full-text screening. Data will be charted using the data charting tool developed by the authors.

Results
The results of this study will be presented in a final scoping review paper, divided into 2 sections. The first section will describe the search strategy and study selection process and will contain the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. The second section will provide key details pertaining to the review objective and question.

Conclusions
This review will help guide scholars looking to build social media health interventions toward evidence-based practices in design and evaluation.

International Registered Report Identifier (IRRID)
PRR1-10.2196/31911
Primary investigating chemical constituents of bioactive extract from Centrostachys aquatica (R.Br.) Wall. ex Moq.-Tand.
Authors: Ngo Quoc Luan , Ta Thao Cuong , Tran Thi Manh Huynh , Le Minh Dan , Ngo Khac Khong Minh , Ngo Trong Nghia , Nguyen Diep Xuan Ky , Phan Nhat Minh , Nguyen Tan Phat 
Published: December 2021

This study is aimed to screen the biological activities and chemical composition to find evidences for potential medicinal applications of Centrostachys aquatica in the Mekong Delta. Crude methanol extract and subextracts in n-hexane, ethyl acetate, and acetone from Centrostachys aquatica were tested bioactivities. The methanol extract, n-hexane and ethyl acetate subextracts exhibited antimicrobial activity with corresponding MIC values of 200, 100 and 200 µg/mL, respectively. The ethyl acetate subextract was inhibited cytotoxicity against cancer cell line LU-1 with IC50 of 27.66 µg/mL. None of the extracts showed antioxidant ability. Three known secondary metabolites including oleanolic acid (1), 20(E)-hydroxy-b-ecdysone (2), and b-spinasterol (3) were isolated for the first time from the bioactive (ethyl acetate) subextract of Centrostachys aquatica. Their structures were elucidated by modern spectra as MS, NMR and comparison with published data.
Karakteristik sifat Fisik Kimia dan Organoleptik Tiwul Instan Protein Tinggi Bersubtitusi Tepung Koro Pedang (Canavalia ensiformis L.)
Authors: Herlina Herlina , Lindriati Triana , Nurhayati Nurhayati , Sulistyani Sulistyani , Hidayati Manik Nur , Utami Elok Sri , Soekarno Siswoyo 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui pengaruh persentase subtitusi tepung koro pedang pada pembuatan tiwul instan protein tinggi terhadap karakteristik fisik, kimia dan organoleptik tiwul instan dan menentukan persentase subtitusi tepung koro pedang yang tepat sehingga dihasilkan tiwul instan yang disukai. Penelitian ini dilakukan dengan Rancangan Acak Lengkap (RAL) faktor tunggal, yaitu persentase subtitusi tepung koro pedang pada pembuatan tiwul instan dan setiap perlakuan dalam penelitian diulang 3 (tiga) kali. Data pengamatan yang didapatkan dianalisis menggunakan uji keragaman (ANOVA) taraf kepercayaan 95% (α≤0,05) dan apabila ada perbedaan yang nyata antar perlakuan (α≤0,05) dilanjutkan dengan uji beda Duncan. Data uji organoleptik dianalisis menggunakan uji chi-square (α≤0,05). Hasil penelitian ini menunjukkan, bahwa peningkatan persentase subtitusi tepung koro pedang menyebabkan peningkatan daya rehidrasi, daya kembang dan kadar protein tiwul instan protein tinggi, namun menyebabkan penurunan terhadap densitas kamba, kecerahan warna dan kadar air tiwul instan protein tinggi yang dihasilkan. Uji organoleptik kesukaan panelis didapatkan persentase tertinggi pada perlakuan P3 (persentase subtitusi tepung koro pedang 30% ) dengan atribut memiliki daya rehidrasi 347%, densitas kamba 0,51 g/mL, daya kembang 35,14%, kecerahan warna 69,87, kadar air 6,05%, dan kadar protein 8,15%, serta persentase kesukaan warna, aroma, rasa, tekstur, dan kekenyalan berturut turut 56, 40, 62, 68, dan 64%.
Using Digital Mind Mapping to Improve Writing Skills
Authors: Sairo Medyana Inna , Ratminingsih Ni Made , Sudira I Gede Arya 
Published: December 2021

There are still many students who lack writing skills. Students are confused about starting a discussion or determining ideas, and the lack of vocabulary makes it difficult for students to write. This study aims to analyze the use of digital mind mapping to improve students' writing skills. This type of research is classroom action research which will be divided into two cycles. cycle 1 in 3 sessions and cycle 2 in 2 sessions. The research subjects were 33 students. The methods used in collecting research data are observation, interviews, and tests. The instruments used to collect data are questionnaires and test sheets. The technique used to analyze the data is descriptive qualitative and quantitative analysis. The results showed that Digital Mind Mapping was effective for improving students' abilities. It was found that the average score of students in the pre-test was 24%, increased to 90% in the post-test I and in the post-test II. There was an increase in the number of students who had not previously achieved the KKM. The increase in the average score of students is also supported by student interest during the teaching and learning process because the method uses technology. In addition, the students found that the Digital Mind Mapping activity helped them organize students' ideas, become critical thinking, creative and improve students' writing.
Perancangan Rrelokasi Tata Letak Gudang Dengan Metode Systematic Layout Planning Pada PT. MKM
Authors: Fajri Ahmad 
Published: December 2021

Studi kasus ini dilakukan pada perusahaan yang fokus pada layanan penyedia jaringan berbasis serat optik dengan menggunakan infrastruktur teknologi terkini yaitu Fiber To The Home (FTTH). Meningkatnya permintaan produk layanan pada studi kasus ini diberbagai wilayah di Indonesia berimbas pada operasional gudang yang secara kapasitas otomatis meningkat. Namun, produk harus tetap dapat disimpan agar terjaga kualitasnya sebelum didistribusikan. Untuk mengatasi ini, diperlukan metode penataan gudang yang baik agar efisiensi Ongkos Material Handling juga dapat tercapai dan mengurangi resiko accident yang berimbas pada kerusakan material. Metode Systematic Layout Planning (SLP) digunaan untuk merancang keterkaitan hubungan aktivitas antar perangkat. metode ini digunakan sebagai perencanaan layout sistematis dengan berdasarkan pada kegiatan operasional yang sedang dilakukan ataupun sebagai peramalan dimasa yang akan datang. hasil pengolahan data menggunakan metode SLP diperoleh bahwa perancangan tata letak usulan lebih baik dengan biaya operasional Rp. 347.795.285 dibandingkan layout awal sebesar Rp. 577.022.833 dengan selisih mencapai RP. 229.227.549 dan efisiensi sebesar 40%. Kata Kunci : Systematic Layout Planning (SLP), Ongkos Material Handling (OMH), Perancangan Tata Letak, Indonesia.