bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik Poli Asam Laktat Glikolat (Kajian Rasio Asam Laktat Limbah Aren-Asam Glikolat)
Authors: Purnavita Sari , Hermawati Lucia , Rinihapsari Elisa 
Published: December 2021

Polimer Poli Asam Laktat Glikolat (PLGA) merupakan salah satu jenis polimer yang telah disetujui FDA dan EMA untuk penggunaan biomedik. Kelebihan PLGA yaitu biokompatibilitas, biodegradabilitas, fleksibilitas, dan efek samping yang minimal. PLGA telah dikembangkan untuk penggunaan medis namun pemenuhannya masih berupa impor. Oleh karena itu, pada penelitian ini monomer asam laktat dari limbah pati aren dan asam glikolat dengan rasio LA:GA = 75%:25%; 90%:10%; 95%:5%; direaksikan secara Ring Opening Polymerization (ROP) dengan bantuan katalis Sn(II) Oktoat membentuk PLGA. PLGA hasil kemudian ditambahkan PVA, dengan rasio PLGA:PVA 3:2; 3:3; 3:4; dan 3:5 dengan metode solution casting membentuk film. Penelitian dilakukan secara eksperimental dengan Rancangan Acak Lengkap (RAL) faktorial. Hasil penelitian menunjukkan adanya kombinasi rasio LA:GA dan rasio penambahan PVA mempengaruhi karakteristik film PLGA. Hasil kekakuan dan Modulus Young film PLGA tertinggi pada kombinasi penambahan rasio LA:GA = 75%:25% dan penambahan rasio PLGA:PVA =3:4. Biodegrabilitas film PLGA terbaik pada kombinasi penambahan rasio LA:GA 90%:10% dan penambahan rasio PLGA:PVA 3:4. Film PLGA memiliki biokompatibilitas yang baik pada semua rasio LA:GA, dengan penambahan rasio PLGA:PVA lebih dari 3:2. Hasil film PLGA memiliki morfologi permukaan paling halus pada rasio penambahan PLGA : PVA 3:2, dan memiliki struktur semi kristalin.Lactic Glycolic Acid Polymer (PLGA) is a type of polymer that has been approved by the FDA and EMA for biomedical use. The advantages of PLGA are biocompatibility, biodegradability, flexibility, and minimal side effects. PLGA has been developed for medical use but fulfillment is still imported. Therefore, in this study, the lactic acid monomer from waste palm starch and glycolic acid with a ratio of LA: GA = 75%: 25%; 90%: 10%; 95%: 5%; reacted with Ring Opening Polymerization (ROP) with the help of a catalyst Sn (II) Octoate to form PLGA. The resulting PLGA was then added with PVA, with a ratio of PLGA: PVA 3: 2; 3: 3; 3: 4; and 3: 5 with the solution casting method forming the film. This research was conducted experimentally with a factorial completely randomized design (CRD). The results showed that the combination of LA: GA ratio and PVA addition ratio affected the PLGA film characteristics. The results of stiffness and Young's Modulus of PLGA film were highest in the combination of addition of the ratio of LA: GA = 75%: 25% and the addition of the ratio of PLGA: PVA = 3: 4. The best PLGA film biodegradability was combined with the addition of the ratio of LA: GA 90%: 10% and the addition of the PLGA: PVA ratio 3: 4. PLGA film has good biocompatibility in all LA: GA ratios, with the addition of a PLGA: PVA ratio of more than 3: 2. The results of the PLGA film had the smoothest surface morphology at the ratio of addition of PLGA: PVA 3: 2, and had a semi-crystalline structure.
Analisis Pertumbuhan Tanaman Cabai Keriting dalam Polybag menggunakan Pupuk Fermentasi Urin Sapi
Authors: Juhariah Jujuk , Aulia Margaretha Praba 
Published: December 2021

Tahun 2020 merupakan tahun yang cukup sulit bagi masyarakat Indonesia. Adanya virus corona jenis baru memaksa masyarakat untuk beradaptasi dengan kebiasaan baru. Salah satu masalah terbesar yang dihadapi adalah dengan adanya kebijakan lockdown yang menyebabkan sulitnya distribusi bahan pangan. Oleh sebab itu edukasi masyarakat untuk memanfaatkan lahan pekarangan secara organik dengan mengoptimalkan sumber daya yang ada disekitar pekarangan rumah perlu dilakukan. Tujuan penelitian ini adalah untuk mengetahui respon tanaman cabai keriting dengan menggunakan pupuk fermentasi urin sapi. Penelitian dilakukan dengan cara memberikan perlakuan variasi pemupukan dengan mencampur urin sapi dan EM4 (perlakuan A); urin sapi, EM4, dan batang pohon pisang (perlakuan B); urin sapi, EM4, dan sabut kelapa (perlakuan C); dan urin sapi, EM4, dan akar kacang tanah (perlakuan D). Parameter yang diamati dalam penelitian ini adalah tinggi tanaman, jumlah daun, diameter batang, dan bobot biomassa kering tanaman. Perlakuan penambahan sabut kelapa pada fermentasi urin sapi memberikan pengaruh yang nyata pada parameter tinggi tanaman. Sedangkan penambahan akar kacang tanah pada fermentasi pupuk urin sapi meningkatkan bobot biomassa kering tanaman secara signifikan. Penambahan batang pohon pisang pada fermentasi urin sapi secara nyata memberikan pengaruh terhadap diameter batang tanaman cabai keriting. Akan tetapi, jumlah daun tidak menunjukkan perbedaan yang signifikan dari semua jenis pemupukan. The year 2020 is quite a difficult year for the people of Indonesia. The existence of a new coronavirus type forces people to adapt to new habits. One of the biggest problems faced is the lockdown policy which makes it difficult for food distribution. Therefore, it is necessary to educate the public to utilize the yard organically by optimizing the existing resources around the yard of the house. This study aimed to determine the response of curly chili plants using cow urine fermentation fertilizer. The research was conducted by giving various fertilization treatments by mixing cow urine and EM4 (treatment A); cow urine, EM4, and banana tree trunks (treatment B); cow urine, EM4, and coconut husk (treatment C); and cow urine, EM4, and groundnut root (treatment D). Parameters observed in this study were plant height, number of leaves, stem diameter, and dry biomass weight of the plant. The addition of coconut fiber in cow urine fermentation has a significant effect on plant height parameters. Meanwhile, the addition of groundnut roots to fermented cow urine fertilizer increased the dry biomass weight of the plant significantly. The addition of banana tree trunks to cow urine fermentation significantly affected the stem diameter of curly chili plants. However, the number of leaves did not show a significant difference between all types of fertilization.
Analysis and modeling of the dynamics of the glow of calcium and hydrogen lines in solar and stellar flares
Authors: Kupryakov Yurij Alekseevich , Bychkov Konstantin Veniaminovich , Belova Oksana Mikhailovna , Gorshkov Alexey Borisovich , Heinzel Petr , Kotrč Pavel 
Published: December 2021

Abstract
We present intensity curves of solar flares obtained in the Hα hydrogen line and CaII H, CaIR 8542Å lines using multichannel spectrographs of Ondřejov Observatory (Czech Republic) for the period 2000–2012. The general behavior of observed intensity curves is practically the same for all flares and is consistent with temporal variations of X-ray emission. However, our results differ significantly from those obtained by other authors for selected flare stars, for example, AD Leo; EV Lac; YZ CMi. We tried to explain the difference in the behavior of Ca II and Hα radiation flux by appearance of a shock wave during a flare and slow heating of the plasma.
Utilization of dolerite waste powder for improving geotechnical parameters of compacted clay soil
Authors: Shah Syed Husnain Ali , Arif Mohammad , ur Rehman Qasim , Manzoor Fawaz 
Published: December 2021

Abstract
This study explores how dolerite cutting waste could be utilized for improving the quality of compacted clay soils. Different proportions of dolerite waste powder with varying grain sizes were used as admixtures and their impact on clay soil properties investigated. Ten samples were prepared by mixing clay soil with different proportions of dolerite waste powder having grain sizes of 0.210, 0.297, and 0.420 mm. The resulting samples were subjected to Proctor compaction, and their maximum dry density and optimum moisture content were measured. Next, all the compacted samples were subjected to geotechnical testing, including the determination of Atterberg limits, California bearing ratio (CBR), unconfined compressive strength, and specific gravity (Gs). The values of compaction parameters, Atterberg limits, and Gs were utilized for finding the porosity, void ratio, saturation potential, liquidity index (LI), and consistency index (CI). The results demonstrate that the addition of dolerite powder produces a substantial improvement in the plasticity index, compaction parameters, CBR, unconfined compressive strength, Gs, porosity, void ratio, degree of saturation, LI, and CI. The foremost reason for this improvement is the presence of denser and less water-adoring minerals in the added dolerite relative to pristine clay soil. Furthermore, the observed positive impact on the soils’ geotechnical comportment is comparatively higher with coarser than finer dolerite because of the decrease in surface area that causes a reduction in the moisture content and porosity but an increase in the density of soil.
Evolutionary adaptation of DHFR via expression of enzyme isoforms with various binding properties and dynamics behavior: a bioinformatics and computational study
Authors: Karimi Elahe , Heshmati Emran , Khalifeh Khosrow 
Published: December 2021

Abstract
We compared the binding properties and dynamics of three experimentally reviewed isoforms of human dihydrofolate reductase (DHFR). The cytoplasmic variants including isoforms1 and 2 (iso1 and iso2) are produced by alternative splicing; while the mitochondrial form is located in the mitochondria. The iso1 as the canonical sequence contains 187 residues, and iso2 differs from the iso1, where it has 1–52 residues missing at the N-terminus of canonical sequence. Here, the structural models of the iso2 and mitochondrial forms were constructed by the MODELLER program using the crystal structure of the iso1 as the template. Bioinformatics analysis on ligand-bearing structures demonstrates that mitochondrial variant forms more stable complex with ligands compared with iso1 and 2, indicating their different binding properties. The root mean square fluctuation (RMSF) data suggest that C-terminus of iso1 contains two representative highly flexible fragments, while iso2 contains a highly flexible fragment at N-terminus end. Interestingly, both ends of mitochondrial variant have a degree of rigidity. Finally, the observation of differences in structural dynamics and binding properties predicts that the simultaneous existence of enzyme isoforms is a way to increase the speed of the enzyme maneuver in response to various environmental conditions. This prediction needs to be tested experimentally.
Novel add-drop filter based on serial and parallel photonic crystal ring resonators (PCRR)
Authors: Fakhruldeen Hassan Falah , Abdul-Jaleel Al-Asady Heba , Mahinroosta Tayebeh , Sohrabi Foozieh , Hamidi Seyedeh Mehri 
Published: December 2021

Abstract
Photonic crystal ring resonators (PCRR) as momentous candidates for future photonic crystal integrated circuits (PCICs) draw worldwide attention. In this paper, different configurations are proposed based on single, parallel, and serial PCRRs. To be precise, the different coupling lengths and alignments have been discussed in double and triple PCRRs in parallel and serial configurations to achieve the highest efficiency concerning the desired applications such as an add-drop filter (ADF) and a power splitter. Moreover, in the achieved optimum double and triple PCRRs, the effect of coupling radius change has been discussed.
Identification of three novel pathogenic mutations in cystathionine beta-synthase gene of Pakistani intellectually disabled patients
Authors: Wasim Muhammad , Khan Haq N. , Ayesha Hina , Iqbal Mazhar , Tawab Abdul , Irfan Muhammad , Kanhai Warsha , Goorden Susanna M. I. , Stroomer Lida , Salomons Gajja , Vaz Frederic M. , Karnebeek Clara D. M. van , Awan Fazli R. 
Published: December 2021

Abstract

Background
Classical homocystinuria (HCU) is an autosomal recessive inborn error of metabolism, which is caused by the cystathionine-β-synthase (CBS: encoded by CBS) deficiency. Symptoms of untreated classical HCU patients include intellectual disability (ID), ectopia lentis and long limbs, along with elevated plasma methionine, and homocysteine.

Methods
A total of 429 ID patients (age range: 1.6–23 years) were sampled from Northern areas of Punjab, Pakistan. Biochemical and genetic analyses were performed to find classical HCU disease in ID patients.

Results
Biochemically, nine patients from seven unrelated families were identified with high levels of plasma methionine and homocysteine. Targeted exonic analysis of CBS confirmed seven causative homozygous mutations; of which three were novel missense mutations (c.451G>T; p.Gly151Trp, c.975G>C; p.Lys325Asn and c.1039 + 1G>T splicing), and four were recurrent variants (c.451 + 1G>A; IVS4 + 1 splicing, c.770C>T; p.Thr257Met, c.808_810del GAG; p.Glu270del and c.752T>C; p.Leu251Pro). Treatment of patients was initiated without further delay with pyridoxine, folic acid, cobalamin, and betaine as well as dietary protein restriction. The immediate impact was noticed in behavioral improvement, decreased irritability, improved black hair color, and socialization. Overall, health outcomes in this disorder depend on the age and symptomatology at the time of treatment initiation.

Conclusions
With personalized treatment and care, such patients can reach their full potential of living as healthy a life as possible. This screening study is one of the pioneering initiatives in Pakistan which would help to minimize the burden of such treatable inborn errors of metabolism in the intellectually disabled patients.
Improvement of the mechanical and damping behavior of nylon by integration of nanoclay platelets
Authors: Subburamamurthy Hari Bodipatti , Rathanasamy Rajasekar , Kumar Harikrishna Kumar Mohan , Chinnasamy Moganapriya , Kaliyannan Gobinath Velu , Natarajan Saravanan 
Published: December 2021

Abstract
Nylon is used as a gear material thanks to its beneficial characteristics, such as self-lubrication, noiseless and fail-safe operation. Poor resistance to heat, dimensional stability, shock and impact loads are major drawbacks of nylon when used in engineering applications. The addition of a nanofiller to a nylon matrix can enhance its mechanical and vibrational properties. Montmorillonite nanoclay (Cloisite 15 A, Cloisite 20 A and Cloisite 30B) modified with ammonium salt was incorporated into the Nylon 6 matrix by solution mixing and melt mixing. Nanoclay with 1, 2 and 3 wt.-% were added to the nylon matrix and the resulting mechanical and free vibration characteristics were determined. The experimental results of the mechanical and free vibration behavior were compared with the ANSYS results. Tensile strength, modulus of elasticity, specific strength, specific stiffness, natural frequency and damping factor were found to increase as the weight percentage of the nanoclay in the nylon matrix increased. Cloisite 30B nanocomposite shows better mechanical and free vibration characteristics when compared with pure Nylon 6, Cloisite 15 A and Cloisite 20 A nanocomposites. The Cloisite 30B nano-composite was prepared with 2 wt.-% shows maximum mechanical and free vibration performance.
Orbital angular momentum and beyond in free-space optical communications
Authors: Wang Jian , Liu Jun , Li Shuhui , Zhao Yifan , Du Jing , Zhu Long 
Published: December 2021

AbstractOrbital angular momentum (OAM), which describes tailoring the spatial physical dimension of light waves into a helical phase structure, has given rise to many applications in optical manipulation, microscopy, imaging, metrology, sensing, quantum science, and optical communications. Light beams carrying OAM feature two distinct characteristics, i.e., inherent orthogonality and unbounded states in principle, which are suitable for capacity scaling of optical communications. In this paper, we give an overview of OAM and beyond in free-space optical communications. The fundamentals of OAM, concept of optical communications using OAM, OAM modulation (OAM modulation based on spatial light modulator, high-speed OAM modulation, spatial array modulation), OAM multiplexing (spectrally efficient, high capacity, long distance), OAM multicasting (adaptive multicasting,N-dimensional multicasting), OAM communications in turbulence (adaptive optics, digital signal processing, auto-alignment system), structured light communications beyond OAM (Bessel beams, Airy beams, vector beams), diverse and robust communications using OAM and beyond (multiple scenes, turbulence-resilient communications, intelligent communications) are comprehensively reviewed. The prospects and challenges of optical communications using OAM and beyond are also discussed at the end. In the future, there will be more opportunities in exploiting extensive advanced applications from OAM beams to more general structured light.
Rewatching, Film, and New Television
Authors: Shuster Martin 
Published: December 2021

AbstractThose of us who are captivated by new television (the sort of serialized television that began largely in the early 1990s), often find ourselves rewatching episodes or whole series. Why? What is the philosophical significance of the phenomenon of rewatching? In what follows, I engage with the ontology of television series in order to think about these questions around rewatching. I conclude by reflecting on what the entire discussion might suggest about the medium of new television, about ourselves, and also about our world and the possibilities of art in it.
Construction of abundant novel analytical solutions of the space–time fractional nonlinear generalized equal width model via Riemann–Liouville derivative with application of mathematical methods
Authors: Seadawy Aly R. , Ali Asghar , Althobaiti Saad , El-Rashidy Khaled 
Published: December 2021

Abstract
The space–time fractional generalized equal width (GEW) equation is an imperative model which is utilized to represent the nonlinear dispersive waves, namely, waves flowing in the shallow water strait, one-dimensional wave origination escalating in the nonlinear dispersive medium approximation, gelid plasma, hydro magnetic waves, electro magnetic interaction, etc. In this manuscript, we probe advanced and broad-spectrum wave solutions of the formerly betokened model with the Riemann–Liouville fractional derivative via the prosperously implementation of two mathematical methods: modified elongated auxiliary equation mapping and amended simple equation methods. The nonlinear fractional differential equation (NLFDE) is renovated into ordinary differential equation by the composite function derivative and the chain rule putting together along with the wave transformations. We acquire several types of exact soliton solutions by setting specific values of the personified parameters. The proposed schemes are expedient, influential, and computationally viable to scrutinize notches of NLFDEs.
Batch effect reduction of microarray data with dependent samples using an empirical Bayes approach (BRIDGE)
Authors: Xia Qing , Thompson Jeffrey A. , Koestler Devin C. 
Published: December 2021

Abstract
Batch-effects present challenges in the analysis of high-throughput molecular data and are particularly problematic in longitudinal studies when interest lies in identifying genes/features whose expression changes over time, but time is confounded with batch. While many methods to correct for batch-effects exist, most assume independence across samples; an assumption that is unlikely to hold in longitudinal microarray studies. We propose Batch effect Reduction of mIcroarray data with Dependent samples usinG
Empirical Bayes (BRIDGE), a three-step parametric empirical Bayes approach that leverages technical replicate samples profiled at multiple timepoints/batches, so-called “bridge samples”, to inform batch-effect reduction/attenuation in longitudinal microarray studies. Extensive simulation studies and an analysis of a real biological data set were conducted to benchmark the performance of BRIDGE against both ComBat and longitudinal
ComBat. Our results demonstrate that while all methods perform well in facilitating accurate estimates of time effects, BRIDGE outperforms both ComBat and longitudinal ComBat in the removal of batch-effects in data sets with bridging samples, and perhaps as a result, was observed to have improved statistical power for detecting genes with a time effect. BRIDGE demonstrated competitive performance in batch effect reduction of confounded longitudinal microarray studies, both in simulated and a real data sets, and may serve as a useful preprocessing method for researchers conducting longitudinal microarray studies that include bridging samples.
Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin
Authors: Ojha Prachi , Pal Subhajit , Bhattacharyya Samarjit 
Published: December 2021

Group I mGluRs have diverse functions in some fundamental neuronal processes, including modulation of synaptic plasticity; and dysregulation of these receptors could lead to various neuropsychiatric disorders. Trafficking of Group I mGluRs plays critical roles in controlling the precise spatiotemporal localization and activity of these receptors, both of which contribute to proper downstream signaling. Using “molecular replacement” approach in hippocampal neurons derived from mice of both sexes, we demonstrate a critical role for the postsynaptic density protein Norbin in regulating the ligand-induced internalization of Group I mGluRs. We show that Norbin associates with protein kinase A (PKA) through its N-terminus and anchors mGluR5 through its C-terminus, both of which are necessary for the ligand-mediated endocytosis of mGluR5, a member of the Group I mGluR family. A point mutation (A687G) at the C-terminus of Norbin inhibits the binding of Norbin to mGluR5 and blocks mGluR5 endocytosis. Finally, we demonstrate an important mechanism by which Norbin regulates mGluR-mediated AMPAR endocytosis in hippocampal neurons, a cellular correlate for mGluR-dependent synaptic plasticity. Norbin, through its PKA-binding regions, recruits PKA to AMPARs on activation of mGluRs; and deletion of the PKA-binding regions of Norbin inhibits mGluR-triggered AMPAR endocytosis. We further report that Norbin is important specifically for the mGluR-mediated AMPAR endocytosis, but not for NMDAR-dependent AMPAR endocytosis. Thus, this study unravels a novel role for Norbin in the internalization of mGluRs and mGluR-mediated AMPAR endocytosis that can have clinical relevance to the function of Group I mGluRs in pathologic processes.SIGNIFICANCE STATEMENTThe postsynaptic protein Norbin interacts with mGluR5, and both of them have been implicated in disorders, such as schizophrenia. However, the mechanistic basis underlying the regulation of mGluRs by Norbin remains elusive. We have identified Norbin as an essential mediator of ligand-mediated endocytosis of Group I mGluRs. Mechanistically, Norbin N-terminus associates with protein kinase-A (PKA) and C-terminus binds to mGluR5 to coordinate receptor internalization. A point mutation NorA687G inhibits endocytosis by disrupting this interaction. Additionally, Norbin is critical for the recruitment of PKA to AMPARs on activation of Group I mGluRs that assists in mGluR-mediated AMPAR endocytosis. Thus, Norbin has a dual function in the hippocampus: regulation of mGluR internalization and PKA-dependent modulation of mGluR-mediated AMPAR endocytosis, a prerequisite for mGluR-mediated synaptic plasticity.