bluuebunny/crossref_metadata_2025_split huggingface dataset:
CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases
Authors: Berndt Nikolaus , Eckstein Johannes , Wallach Iwona , Nordmeyer Sarah , Kelm Marcus , Kirchner Marieluise , Goubergrits Leonid , Schafstedde Marie , Hennemuth Anja , Kraus Milena , Grune Tilman , Mertins Philipp , Kuehne Titus , Holzhütter Hermann-Georg 
Published: November 2021

Background:

Many heart diseases can result in reduced pumping capacity of the heart muscle. A mismatch between ATP demand and ATP production of cardiomyocytes is one of the possible causes. Assessment of the relation between myocardial ATP production (MV
ATP
) and cardiac workload is important for better understanding disease development and choice of nutritional or pharmacologic treatment strategies. Because there is no method for measuring MV
ATP
in vivo, the use of physiology-based metabolic models in conjunction with protein abundance data is an attractive approach.

METHOD:

We developed a comprehensive kinetic model of cardiac energy metabolism (CARDIOKIN1) that recapitulates numerous experimental findings on cardiac metabolism obtained with isolated cardiomyocytes, perfused animal hearts, and in vivo studies with humans. We used the model to assess the energy status of the left ventricle of healthy participants and patients with aortic stenosis and mitral valve insufficiency. Maximal enzyme activities were individually scaled by means of protein abundances in left ventricle tissue samples. The energy status of the left ventricle was quantified by the ATP consumption at rest (MV
ATP
[rest]), at maximal workload (MV
ATP
[max]), and by the myocardial ATP production reserve, representing the span between MV
ATP
(rest) and MV
ATP
(max).

Results:

Compared with controls, in both groups of patients, MV
ATP
(rest) was increased and MV
ATP
(max) was decreased, resulting in a decreased myocardial ATP production reserve, although all patients had preserved ejection fraction. The variance of the energetic status was high, ranging from decreased to normal values. In both patient groups, the energetic status was tightly associated with mechanic energy demand. A decrease of MV
ATP
(max) was associated with a decrease of the cardiac output, indicating that cardiac functionality and energetic performance of the ventricle are closely coupled.

Conclusions:
Our analysis suggests that the ATP-producing capacity of the left ventricle of patients with valvular dysfunction is generally diminished and correlates positively with mechanical energy demand and cardiac output. However, large differences exist in the energetic state of the myocardium even in patients with similar clinical or image-based markers of hypertrophy and pump function.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifiers: NCT03172338 and NCT04068740.
Confidence-Controlled Hebbian Learning Efficiently Extracts Category Membership From Stimuli Encoded in View of a Categorization Task
Authors: Berlemont Kevin , Nadal Jean-Pierre 
Published: November 2021

Abstract
In experiments on perceptual decision making, individuals learn a categorization task through trial-and-error protocols. We explore the capacity of a decision-making attractor network to learn a categorization task through reward-based, Hebbian-type modifications of the weights incoming from the stimulus encoding layer. For the latter, we assume a standard layer of a large number of stimulus-specific neurons. Within the general framework of Hebbian learning, we have hypothesized that the learning rate is modulated by the reward at each trial. Surprisingly, we find that when the coding layer has been optimized in view of the categorization task, such reward-modulated Hebbian learning (RMHL) fails to extract efficiently the category membership. In previous work, we showed that the attractor neural networks' nonlinear dynamics accounts for behavioral confidence in sequences of decision trials. Taking advantage of these findings, we propose that learning is controlled by confidence, as computed from the neural activity of the decision-making attractor network. Here we show that this confidence-controlled, reward-based Hebbian learning efficiently extracts categorical information from the optimized coding layer. The proposed learning rule is local and, in contrast to RMHL, does not require storing the average rewards obtained on previous trials. In addition, we find that the confidence-controlled learning rule achieves near-optimal performance. In accordance with this result, we show that the learning rule approximates a gradient descent method on a maximizing reward cost function.
Bridging the Functional and Wiring Properties of V1 Neurons Through Sparse Coding
Authors: Hu Xiaolin , Zeng Zhigang 
Published: November 2021

Abstract
The functional properties of neurons in the primary visual cortex (V1) are thought to be closely related to the structural properties of this network, but the specific relationships remain unclear. Previous theoretical studies have suggested that sparse coding, an energy-efficient coding method, might underlie the orientation selectivity of V1 neurons. We thus aimed to delineate how the neurons are wired to produce this feature. We constructed a model and endowed it with a simple Hebbian learning rule to encode images of natural scenes. The excitatory neurons fired sparsely in response to images and developed strong orientation selectivity. After learning, the connectivity between excitatory neuron pairs, inhibitory neuron pairs, and excitatory-inhibitory neuron pairs depended on firing pattern and receptive field similarity between the neurons. The receptive fields (RFs) of excitatory neurons and inhibitory neurons were well predicted by the RFs of presynaptic excitatory neurons and inhibitory neurons, respectively. The excitatory neurons formed a small-world network, in which certain local connection patterns were significantly overrepresented. Bidirectionally manipulating the firing rates of inhibitory neurons caused linear transformations of the firing rates of excitatory neurons, and vice versa. These wiring properties and modulatory effects were congruent with a wide variety of data measured in V1, suggesting that the sparse coding principle might underlie both the functional and wiring properties of V1 neurons.
Validation and Utility of Satellite Retrievals of Atmospheric Profiles in Detecting and Monitoring Significant Weather Events
Authors: Kalluri S. , Barnet C. , Divakarla M. , Esmaili R. , Nalli N. , Pryor K. , Reale T. , Smith N. , Tan C. , Wang T. , Warner J. , Wilson M. , Zhou L. , Zhu T. 
Published: November 2021

Abstract
Infrared and microwave sounder measurements from polar-orbiting satellites are used to retrieve profiles of temperature, water vapor, and trace gases utilizing a suite of algorithms called the National Oceanic and Atmospheric Administration (NOAA) Unique Combined Atmospheric Processing System (NUCAPS). Meteorologists operationally use the retrievals similar to radiosonde measurements to assess atmospheric stability and aid them in issuing forecasts and severe weather warnings. Measurements of trace gases by NUCAPS enable detection, tracking, and monitoring of greenhouse gases and emissions from fires that impact air quality. During the polar winters, when ultraviolet measurements of ozone are not possible, absorption features in the infrared spectrum of the sounders enable the assessment of ozone concentration in the stratosphere. These retrievals are used as inputs to monitor the ozone hole over Antarctica. This article illustrates the utility of NUCAPS atmospheric profile retrievals in assessing meteorological events using several examples of severe thunderstorms, tropical cyclones, fires, and ozone maps.
Equilibration of Baroclinic Instability in Westward Flows
Authors: Radko Timour , McWilliams James C. , Sutyrin Georgi G. 
Published: November 2021

Abstract
We explore the dynamics of baroclinic instability in westward flows using an asymptotic weakly nonlinear model. The proposed theory is based on the multilayer quasigeostrophic framework, which is reduced to a system governed by a single nonlinear prognostic equation for the upper layer. The dynamics of deeper layers are represented by linear diagnostic relations. A major role in the statistical equilibration of baroclinic instability is played by the latent zonally elongated modes. These structures form spontaneously in baroclinically unstable systems and effectively suppress the amplification of primary unstable modes. Special attention is given to the effects of bottom friction, which is shown to control both linear and nonlinear properties of baroclinic instability. The reduced-dynamics model is validated by a series of numerical simulations.
The isocitrate dehydrogenase 1 is a potential prognostic indicator for non-small cell lung cancer patients
Authors: Zhang Xintong , Ma Shang , Chen Yan , Yin Yanjun , Bai Wanqiu , Tan Jinjing , Shi Guangli 
Published: November 2021

Background The serum isocitrate dehydrogenase 1(IDH1) level is significantly elevated in patients with non-small cell lung cancer (NSCLC) and has important clinical value as a marker for early diagnosis. This study examined the dynamic changes of serum IDH1 levels of patients with NSCLC undergoing surgery or medical treatment, to evaluate its potential prognostic value. Methods The study cohort included 83 NSCLC patients who underwent surgery, 37 NSCLC patients who underwent medical treatment, 50 healthy controls, and 52 disease controls. Serum levels of IDH1 were assayed by enzyme-linked immunoassay. Tumor biomarkers including carcinoembryonic antigen, squamous cell carcinoma, neuron-specific enolase, CYFRA21-1, and pro-gastrin-releasing peptide—which are currently used in clinical practice—were measured by automatic immunoanalyzers. Results Serum IDH1 was significantly higher in patients with NSCLC compared with healthy people or patients with benign lung diseases ( p < 0.001). The area under the receiver operating characteristic curve for diagnosis and differential diagnosis were 0.897 and 0.879, respectively, which were superior to the five tumor markers. Serum IDH1 levels decreased in most patients after surgery, with the most dramatic changes in patients with stage I tumors compared with stage II and III. Analyses of changes in the serum IDH1 level of patients after receiving chemotherapy or targeted therapy revealed that for patients with progressive disease, serum IDH1 increased significantly after treatment; for patients with partial response or stable disease, it decreased steadily. Conclusion IDH1 has potential prognostic value and may be used as a marker for the monitoring of treatment efficacy.
The association of six‐minute walk work and other clinical measures to cardiopulmonary exercise test parameters in pulmonary vascular disease
Authors: C. Robertson Lucy , E. Oates Katrina , J. Fletcher Andrew , P. Sylvester Karl 
Published: November 2021

IntroductionIn pulmonary vascular disease exercise, abnormalities can include reduced exercise capacity, reduced oxygen pulse and elevated VE/VCO2. The association of clinical measures such as six‐minute walk work, haemodynamics, lung function and echocardiogram to peak VO2, O2 pulse and VE/VCO2 has not been fully investigated in pulmonary vascular disease.AimsTo determine the relationship of six‐minute walk work and other clinical measures to peak VO2, peak O2 pulse and VE/VCO2. Additionally, to investigate the ability to predict peak VO2 from six‐minute walk work and other clinical parameters.MethodsClinical data was retrospectively analysed from 63 chronic thromboembolic pulmonary hypertension (CTEPH) and 54 chronic thromboembolic disease (CTED) patients. Six‐minute walk test measures, haemodynamics, lung function and echocardiographic measures were correlated with peak VO2, peak O2 pulse and VE/VCO2. Predictive equations were developed to predict peak V̇O2 in both CTEPH and CTED cohorts and subsequently validated.ResultsA number of clinical parameters correlated to peak VO2, peak O2 pulse and VE/VCO2. Six‐minute walk work and transfer factor for carbon monoxide demonstrated the strongest correlation to peak VO2 and peak O2 pulse. The validation of the predictive equations showed a variable level of agreement between measured peak VO2 and calculated peak VO2 from the predictive equations.ConclusionSix‐minute walk work and additionally a number of clinical test parameters were associated to peak VO2, peak O2 pulse and VE/VCO2. Six‐minute walk work and transfer factor for carbon monoxide were particularly highly correlated to peak VO2 and similarly to peak oxygen pulse. The validation of the predictive equations showed a variable level of agreement and therefore may have limited clinical applicability.
Different clinical symptom patterns in patients with reflux micro-aspiration
Authors: Khoma Oleksandr , Park Jin-soo , Lee Felix Michael , Van der Wall Hans , Falk Gregory L. 
Published: November 2021

BackgroundPulmonary manifestation of gastro-oesophageal reflux disease (GORD) is a well-recognised entity; however, little primary reported data exists on presenting symptoms of patients in whom reflux micro-aspiration is confirmed. The aim of this study is to report symptoms and presenting patterns of a large group of patients with confirmed reflux micro-aspiration.Patients and methodsData was extracted from a prospectively populated database of patients referred to a tertiary specialist centre with severe, refractory or atypical reflux. Patients with reflux micro-aspiration on scintigraphy were included in this study. A separate group included patients with evidence of proximal reflux to the level of pharynx when supine and/or upright.ResultsInclusion criteria were met by 243 patients with confirmed reflux micro-aspiration (33% males; mean age 59). Most common symptoms amongst patients with micro-aspiration were regurgitation (72%), cough (67%), heartburn (66%), throat clearing (65%) and dysphonia (53%). The most common two-symptom combinations were heartburn/regurgitation, cough/throat clearing, regurgitation/throat clearing, cough/regurgitation and dysphonia/throat clearing. The most common three-symptom combinations were cough/heartburn/regurgitation, cough/regurgitation/throat clearing and dysphonia/regurgitation/throat clearing. Cluster analysis demonstrated two main symptom groupings, one suggestive of proximal volume reflux symptoms and the other with motility/inflammatory bowel syndrome-like symptoms (bloat, constipation).ConclusionThe combination of typical symptoms of GORD such as heartburn or regurgitation and a respiratory or upper aero-digestive complaint such as cough, throat clearing or voice change should prompt consideration of reflux micro-aspiration.
Perceived determinants of implementation success of the neglected tropical diseases programme in Ghana: a qualitative study among programme officers
Authors: Otoo Desmond Dzidzornu , Appiah-Agyekum Nana Nimo , Adzei Francis Anderson 
Published: November 2021

Abstract
Background
The importance of health policy implementation cannot be overemphasized in contemporary public health. Neglected Tropical Diseases (NTDs) have negatively impacted society, affect quality of life and make the poor societies poorer. Several policies and strategies have been put in place across the world including the neglected tropical diseases programme in Ghana. Though chalked many successes, the programme continues to lag behind in the full attainment of various objectives. Several factors exist that determine how effective a programme is implemented. Identification of these factors on every programme is essential to determine where more programme resources need to be channelled. This study assessed the determinants of successful implementation of the neglected tropical diseases programme in Ghana.

Methods
A qualitative approach with the case study design was employed. Purposive and snowball sampling techniques were used to identify key programme officers at the national, regional and district levels of programme implementation. Eighteen (18) Key informant interviews were conducted at all the three levels of the Ghana Health Service NTDs programme. Data were thematically analysed and presented.

Results
Findings from the study revealed that determinants that influenced the successful implementation of the NTDs programme include donor support, education and training, partnerships, reliability of the health structure, integrative nature of the programme and management commitment. These determining factors cut across the inner settings of the implementing agency and the external environment.

Conclusion
Neglected tropical diseases continuously affect Ghanaians, especially the poor. It is important for both policy makers and implementers to identify the factors that ensure the success of the programme in the Ghanaian context. Though the factors are independently sufficient, they synergistically lead to improved programme implementation. Empowering all units involved (local to national level) and maximizing the enabling factors identified to would improve upon implementation and ensure sustainability.
Association of multidimensional poverty and tuberculosis in India
Authors: Pathak Dimpal , Vasishtha Guru , Mohanty Sanjay K. 
Published: November 2021

Abstract
Background
Reduction of multidimensional poverty and tuberculosis are priority development agenda worldwide. The SDGs aims to eradicate poverty in all forms (SDG 1.2) and to end tuberculosis (SDG 3.3.2) by 2030. While poverty is increasingly being measured across multiple domains, reduction of tuberculosis has been an integral part of public health programmes. Though literature suggests a higher prevalence of tuberculosis among the economically poor, no attempt has been made to understand the association between multidimensional poverty and tuberculosis in India. The objective of this paper is to examine the association of multidimensional poverty and tuberculosis in India.

Methods
The unit data from the National Family Health Survey-4, conducted in 2015–16 covering 628,900 households and 2,869,043 individuals across 36 states and union territories of India was used in the analysis. The survey collected information on the self-reported tuberculosis infection of each member of a sample household at the time of the survey. Multidimensional poverty was measured in the domains of education, health, and standard of living, with a set of 10 indicators. The prevalence of tuberculosis was estimated among the multidimensional poor and non-poor populations across the states of India. A binary logistic regression model was used to understand the association of tuberculosis and multidimensional poverty.

Results
Results suggest that about 29.3% population of India was multidimensional poor and that the multidimensional poverty index was 0.128. The prevalence of tuberculosis among the multidimensional poor was 480 (95% CI: 464–496) per 100,000 population compared to 250 (95% CI: 238–262) among the multidimensional non-poor. The prevalence of tuberculosis among the multidimensional poor was the highest in the state of Kerala (1590) and the lowest in the state of Himachal Pradesh (220). Our findings suggest a significantly higher prevalence of tuberculosis among the multidimensional poor compared to the multidimensional non-poor in most of the states in India. The odds of having tuberculosis among the multidimensional poor were 1.82 times higher (95% CI, 1.73–1.90) compared to the non-poor. Age, sex, smoking, crowded living conditions, caste, religion, and place of residence are significant socio-demographic risk factors of tuberculosis.

Conclusion
The prevalence of tuberculosis is significantly higher among the multidimensional poor compared to the multidimensional non-poor in India.
LncRNA GAS5 participates in childhood pneumonia by inhibiting cell apoptosis and promoting SHIP-1 expression via downregulating miR-155
Authors: Wang Xiaoping , Guo Ping , Tian Jiahui , Li Jie , Yan Na , Zhao Xin , Ma Yue 
Published: November 2021

Abstract
Background
LncRNA GAS5 and miR-155 are reported to play opposite roles in lung inflammatory responses. Lung inflammation participates in childhood pneumonia, indicating the involvement of GAS5 and miR-155 in pneumonia. The study aimed to analyze the potential interaction between GAS5 and miR-155 in childhood pneumonia.

Methods
GAS5 and miR-155 levels in plasma samples from pneumonia patients and controls were detected using RT-qPCR. The role of GAS5 in miR-155 RNA gene methylation in human bronchial epithelial cells (HBEpCs) was analyzed by methylation analysis. Flow cytometry and RT-qPCR were applied to analyze cell apoptosis and SHIP-1 expression, respectively.

Results
GAS5 was downregulated in pneumonia, and miR-155 was upregulated in pneumonia. GAS5 and miR-155 were inversely correlated. GAS5 overexpression decreased miR-155 expression in HBEpCs, while miR-155 overexpression showed no significant effects on GAS5 expression. In addition, GAS5 suppressed LPS-induced HBEpC apoptosis, promoted SHIP-1 expression, and reduced the enhancing effect of miR-155 on cell apoptosis and SHIP-1 expression.

Conclusions
GAS5 may participate in childhood pneumonia by inhibiting cell apoptosis and promoting SHIP-1 expression via downregulating miR-155.
Adapting the patient and physician versions of the 9-item shared decision making questionnaire for other healthcare providers in Japan
Authors: Goto Yuko , Yamaguchi Yasuhiro , Onishi Joji , Arai Hidenori , Härter Martin , Scholl Isabelle , Kriston Levente , Miura Hisayuki 
Published: November 2021

Abstract
Background
In Japan, the number of older people with various health problems and difficulties in living is increasing. In order to practice patient-centered care for them, not only medical professionals but also multidisciplinary teams including care professionals and patients need to practice shared decision making (SDM) in the context of long-term care. For this reason, a measure of SDM in consultations with healthcare professionals (HCPs) other than physicians is needed. Therefore, this study aimed at adapting the patient and physician versions of the 9-item Shared Decision Making Questionnaire (SDM-Q-9, SDM-Q-Doc) for consultations with HCPs other than physicians in Japan.

Methods
A pair of SDM measures that can be used by HCPs other than physicians, “Care SDM-Questionnaire for care receivers (SDM-C-patient)” and “Care SDM-Questionnaire for care providers (SDM-C-provider)” were prepared based on the Japanese versions of the SDM-Q-9 and SDM-Q-Doc. The internal consistency and conceptual structure of these measures were tested by secondary analysis of data from 496 participants from a workshop on SDM for different HCPs. Measurement invariance were tested by multigroup confirmatory factor analysis (CFA) for the patient (SDM-C-patient and SDM-Q-9) and provider (SDM-C-provider vs. SDM-Q-Doc) versions.

Results
Both the Japanese SDM-C-patient and SDM-C-provider demonstrated high internal consistencies (Cronbach’s α coefficient was 0.90 and McDonald’s ω coefficient was 0.90 for both measures). CFA showed one-factor structures for both measures and original measures for physicians. Moreover, multigroup CFA showed configural and metric invariance between the novel care measures and original physician’s measures.

Conclusions
Thus, the novel SDM measures for care providers in Japan as well as the original physician’s measures could be used in training setting. As these measures were tested only in a training setting, their reliability and validity as new measures for care should be tested in a clinical setting in future.