bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection, Optimization and Compensation Strategies and Their Relationship with Well-Being and Impulsivity in Early, Middle and Late Adulthood in a Polish Sample
Authors: Zając-Lamparska Ludmiła 
Published: July 2021

Abstract
Background: Selection, optimization and compensation strategies (SOC strategies) are the life management strategies that contribute to successful development. The studies conducted so far have consistently indicated a relationship between the use of these strategies and well-being. In contrast, the relationship between SOC strategies and impulsivity has not yet been empirically examined, although there are premises to assume its existence. The aim of the study was to compare the use of SOC strategies in early, middle and late adulthood, and to investigate the relationship between the use of SOC strategies and well-being and impulsivity. In addition, the study involved a newly developed Polish version of the SOC Questionnaire (SOC48-PL).Methods: The study sample comprised 589 Poles from three age groups: early adulthood (n = 186, 20-35 years), middle adulthood (n = 165, 40-55 years) and late adulthood (n = 238, 60-85 years). In the study, in addition to the SOC48-PL questionnaire, the Short Depression-Happiness Scale (SDHS) and the Short UPPS-P Impulsivity Scale (S UPPS-P) were used.Results: Developmental differences in the use of SOC strategies are rather slight, with a considerable individual differences within age groups. The study revealed some indications of a “developmental peak” of SOC strategies in middle adulthood. The use SOC strategies is positively related to well-being. In turn, the relationship between the use of SOC strategies and impulsivity is negative, especially for two dimensions of impulsivity: lack of premeditation and lack of perseverance. Conclusions: The results only slightly confirm the assumed age-related differences in the use of SOC strategies and point to a large role of individual differences. The revealed relationships of SOC strategy use with well-being and impulsivity are consistent with expectations. The results obtained in the Polish sample confirm the repeatedly revealed positive role of the SOC strategies use for well-being. In contrast, the negative association of SOC strategy use with impulsivity may suggest that for impulsive individuals, spontaneous use of these life-management strategies may be difficult and less likely than those with low impulsivity.
Deacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance
Authors: Liu Zhiqiang , Li Xin , Wang Sheng , Xie Ying , Jiang Hongmei , Wang Jingjing , Guo Jing , Wang Qiang , Ye Lingqun , Wang Yixuan , Peng Ziyi , Wang Mengqi , Wang Jingya 
Published: July 2021

Abstract
Acquired chemoresistance to proteasome inhibitors (PIs) is a major obstacle that results in failure to manage patients with multiple myeloma (MM) in the clinic; however, the key regulators and underlying mechanisms are still unclear. In this study, we found that high levels of a chromosomal modifier, heterochromatin protein 1 gamma (HP1γ), are accompanied by a low acetylation level in bortezomib-resistant (BR) MM cells, and aberrant DNA repair capacity is correlated with HP1γ overexpression. Mechanistically, the deacetylation of HP1γ at lysine 5 by histone deacetylase 1 (HDAC1) alleviates HP1γ ubiquitination, and the stabilized HP1γ recruits the mediator of DNA damage checkpoint 1 (MDC1) to induce DNA damage repair. Simultaneously, deacetylation modification and MDC1 recruitment enhance the nuclear condensate of HP1γ, which facilitates the chromatin accessibility of genes governing sensitivity to PIs, such as FOS, JUN and CD40. Thus, targeting HP1γ stability using the HDAC1/2 inhibitor, romidepsin, sensitizes PIs treatment and overcomes drug resistance both in vitro and in vivo. Our findings elucidate a previously unrecognized role of HP1γ in the acquired drug resistance of MM and suggest that targeting HP1γ may be efficacious for overcoming drug resistance in MM patients.
Effect of pH on the Conformational Transition of Silk Fibroin in Aqueous Solution Monitored by Thioflavin-T Fluorescence
Authors: Jia Ben , Jia Lan , Zhu Jingxin 
Published: July 2021

Abstract
In this work, the potential application of the fluorescence dye Thioflavin-T (ThT), which can specifically bind to amyloid, as a powerful tool for monitoring secondary structure transitions of silk fibroin (SF) induced by pH was examined. Results showed that ThT emission intensities substantially increased when pH decreased from 6.8 to 4.8. This increase may be due to conformational transitions from random coil to β-sheet. The morphology and secondary structure of SF were also investigated via TEM, AFM and circular dichroism spectroscopy. The information obtained herein can be utilized not only for the development of convenient and efficient noninvasive method for monitoring the assembly behavior of SF in aqueous solution but also for in vitro fluorescence imaging.
Formation Mechanism of Well-Ordered Densely Packed Nanoparticle Superlattices Deposited from Gas Phase on Template-Free Surfaces
Authors: Liu Chang , Liu Fei , Jin Chen , Zhang Sishi , Zhang Lianhua , Han Min 
Published: July 2021

Abstract
Superlattices of nanoparticles are generally produced based on solution chemistry processes. In this paper, we demonstrate that self-assembled monolayer structures of nanoparticles with superlattice periodicities can also be produced on template-free surfaces in the gas phase cluster beam deposition process. It is found the packing of Fe nanoparticles corresponds to an average two-dimensional densely-packed lattice with a hexagonal summary. By controlling the nanoparticle coverage, the two-dimensional densely-packed monolayer morphology can spread to the whole substrate surface being deposited. A formation mechanism of the ordered monolayers is proposed by considering the balance between the diffusion rate of the nanoparticles and their filling speed on the substrate surface determined by the deposition rate, and the ordering driven by the inter-particle attractive forces. The model is strongly supported by a serial of carefully designed cluster deposition experiments.
Panel of COVID-19 phenotypes: systematic review protocol
Authors: Silveira Luciana Carvalho , Moraes Yanca Carollynne Souza , Santos Rodrigo da Silva , Reis Angela Adamski da Silva 
Published: July 2021

Abstract
Background The pandemic caused by the SARS-CoV-2 virus, called coronavirus disease 2019 (COVID-19), had an unexpected impact on much of the world, especially Brazil. People diagnosed with the virus manifest different levels of respiratory symptoms, ranging from mild to severe, and may need mechanical ventilation support. The interaction different factors lead to the development of a spectrum of time-related diseases in different phenotypes. Methods This review will consider observational studies published from December 2019 to July 2021, without language restrictions. Studies involving human subjects, adult participants (18 years and older), with subjects who have received a COVID-19 diagnosis using the reverse transcriptase polymerase chain reaction (RT-PCR) test as a reference for the detection of the SARS- CoV-2 virus, according to World Health Organization (WHO) guidance. The databases to be searched will include PubMed/MEDLINE, EMBASE, and CINAHL. The grey literature will also be searched for published research and unpublished studies, using Google Scholar. wo reviewers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion. Findings will be reported using a narrative synthesis of the results will be carried out around the prevalence, severity of the disease, mortality and risk among the different phenotypes of COVID-19. The I 2 statistic will be used to examine the heterogeneity between the studies, if possible, the meta-analysis will be conducted using the RStudio® statistical software package, and the data will be displayed using forest graphics. Discussion This review will disclose a panel of the different manifestations of the disease COVID-19, and to identify the real risk factor for the most serious phenotypes. Systematic review registration This protocol has been registered within the International Prospective Register of Systematic Reviews (PROSPERO)(CRD42020211439)
Necrosis, as Identified on Pre-Radiotherapy 18F-FDG PET/CT, is a Predictor for Complete Metabolic Response in Patients with Non-Small Cell Lung Cancer.
Authors: Eren Gülnihan , Kupik Osman 
Published: July 2021

Abstract
Purpose: To investigate necrosis on pre-radiotherapy (RT) 18F-FDG PET/CT (PETNECROSİS) is a predictor for complete metabolic response (CMR) in patients with non-small cell lung cancer (NSCLC).Methods: We studied patients with inoperable stage I-III NSCLC who underwent pre- and post-radiotherapy 18F-FDG PET/CT. The relationship between CMR and PETNECROSIS, SUVmax, gross tumor volume calculated with 18F-FDG PET/CT (GTVPET-CT), tumor size, histology, metabolic tumor volume (MTV), and RT dose was assessed using logistic regression analysis. To evaluate necrosis on 18F FDG PET/CT, we drew a region of interest (ROI) in the area showing visually very low/or no fluorodeoxyglucose (FDG) uptake on PET images. If the SUVmax was lower than the blood pool SUVmax and showed significantly lower attenuation [10 to 30 Hounsfield Units (HU)] from the surrounding tissue on non-intravenous contrast-enhanced low dose correlative CT, we defined it as necrotic (PETNECROSİS).Results: Fifty-three patients were included in the study. The mean age was 68.1±9.8 years. Twenty-one patients had adenocarcinoma, 32 had squamous cell carcinoma. All parameters were independent of histologic status. Multivariate logistic regression analysis showed that, SUVmax ≤11.6vs>11.6 (p=0.003, OR:7.670, 95CI%:2.013-29.231) and PETNECROSİS absence/presence were independent predictors for CMR (p=0.028, OR:6.704, 95CI%1.214-30.394).Conclusion: The necrosis on 18F FDG PET/CT and SUVmax>11.6 could be an imaging marker for the complete metabolic response after chemoradiotherapy or RT alone in patients with NSCLC.
COVID-19 Vaccine Hesitancy among University Students in Lebanon
Authors: Hamdan Mirna Bou , Singh Shipra , Polavarapu Mounika , Jordan Timothy , Melhem Nada 
Published: July 2021

Abstract
Background
Lebanon has one of the lowest reported COVID-19 vaccine acceptance rates (21%). Little is known about the decision-making process of college students in Lebanon regarding obtaining a COVID-19 vaccination. Therefore, the aim of this study was to identify factors that predicted the behavioral intentions of students enrolled at the American University of Beirut (AUB), Lebanon to obtain a COVID-19 vaccine.
Methods
The study was a randomized, non-experimental, and cross-sectional study of undergraduate and graduate students. A valid and reliable survey was developed. A total of 3,805 students were randomly selected to participate from all academic units. A total of 800 students responded (21% return rate).
Results
We generated three groups based on students’ intentions to be vaccinated: 1) vaccine accepting (those who are willing to take or already took the vaccine); 2) vaccine hesitant (those who are hesitant to take the vaccine); and 3) vaccine resistant (those who decided not to take the vaccine). The majority were Lebanese (85%), undergraduate students (75%), females (57%) with a mean age of 21 ± 0.14 years. Overall, students were vaccine accepting. Specifically, they were vaccine accepting (87%), vaccine hesitant (10%), and vaccine resistant (3%). Vaccine hesitancy was significantly associated with nationality, residency status and university rank (p value < 0.05). Moreover, there was a significant association between hesitancy and agreement with conspiracies. A significant factor for hesitancy was disagreement with the statement that symptomatic cases are the only carriers of COVID-19 (OR = 5; 95% CI = 1.67–14.29; p value = 0.004). Students believed that that the vaccine was safe (OR = 0.01; 95% CI = 0.002–0.08; p value = 0.000); in agreement with their personal views (OR = 0.1; 95% CI = 0.02–0.51; p value = 0.004) and were less likely to be hesitant than the vaccine accepting group (reference group).
Conclusion
The factors identified that explain and/or predict each of the three vaccine intention groups can be used as core content for health communication and social marketing campaigns to increase the rate of COVID-19 vaccination.
The effect of biopreparations of nodules bacteria with carmoisine on the formation and functioning of the soybean – Bradyrhizobium japonicum symbiotic systems
Authors: Kukol Ekaterina , Vorobey Nadiya , Pukhtaievych Petro , Kots Sergii 
Published: July 2021

Purpose. Investigate the formation and functioning of symbiotic systems of soybeans with nodule bacteria by ino­culation of seeds with biological products based on fungicide-resistant strains of Bradyrhizobium japonicum PC07 and B78 with different rates of synthetic carmoisine colorant.
Methods. Physiological, microbiological, gas chromatography, statistical.
Results. It was found that as a result of inoculation of soybean [Glycine max (L.) Merr] variety ‘Almaz’ with microbial preparations based on B. japonicum PC07 and B78, with the addition of carmoisine (0.25 and 0.5 g per 200 g of the preparation), the amount and the weight of nodules formed on the roots during the growing season were at the level of the control plants or exceeded them. The greatest difference in indicators of quantity and weight of root nodules between plants of control and experimental variants is noted in a phase of full flowering at inoculation by both strains of rhizobia and addition to biological products of various norms of dye. Analysis of nitrogen-fixing activity (NFA) of the formed symbiotic systems showed the absence of a negative effect of the synthetic colorant on its level. When inoculated with soybean seeds B. japonicum PC07 in the phase of three true leaves, NFA was higher by 15.6–25.9% and in the budding-beginning of flowering stage by 7.4–29.5% compared with control plants with the addition of 0.25 and 0.5 g of carmoisine, respectively. Against the background of bacterization of soybean seeds by strain B78 before the phase of full flowering of plants the level of N2 assimilation by adding 0.25 g of carmoisine to the vermiculite preparation was at the level of the control plants. During the period of full flowering, this figure exceeded the indicators of control plants by 7.6 and 18.8% with the introduction of 0.25 and 0.5 g of the colorant.
Conclusions. Carmoisine can be applied in the further study of the effectiveness of its use as a dye identifier for controlling the uniformity of marking of loose bacterial preparations on seeds by adding 0.25 and 0.5 g per 200 g of a biopreparation, since this did not show a negative impact on the formation and functioning of the soybean – Bradyrhizobium japonicum symbiotic systems.
Kinetic and thermodynamic studies of polyvinyl chloride composite of manganese oxide nanosheets for the efficient removal of dye from water
Authors: Saeed Tooba , Naeem Abdul , Mahmood Tahira , Khan Afsar , Ahmad Zahoor , Hamayun Muhammad , Khan Ihtisham Wali , Khan Nazish Huma 
Published: July 2021

Abstract
Manganese oxide nanosheets and manganese oxide composite with polyvinyl chloride (MnO2-PVC) were synthesized by the oxidation method for the efficient removal of Congo red (CR). The Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive X-ray, surface area (SA), point of zero charge (PZC) and thermogravimetric analysis were performed to verify the newly synthesized adsorbents. After functionalizing the surface of MnO2 nanosheets with PVC, the PZC and SA were amplified from 4.10 and 214 m2g−1 to 5.01 and 226 m2g−1, respectively. The batch adsorption results showed that the removal capacity of CR on both the adsorbents decreased with the increase of pH and time, but increased with the increase of adsorbent dosage. However, due to the high stability, porosity and greater surface area, the PVC composite of MnO2 was found to exhibit 15 times greater CR removal efficiency than its parent MnO2. Furthermore, the thermodynamic parameters specified that CR adsorption onto both the adsorbents was exothermic, spontaneous and film diffusion accompanied by the intraparticle diffusion is the rate controlling step. These results validate that MnO2 composite with PVC is a useful, eco-friendly, competent candidate for dye removal from wastewater.
The Role of PCSK9 in Infectious Diseases
Authors: Magnasco Laura , Sepulcri Chiara , Antonello Roberta Maria , Di Bella Stefano , Labate Laura , Luzzati Roberto , Giacobbe Daniele Roberto , Bassetti Matteo 
Published: July 2021

Background:
In recent years, many aspects of the physiological role of PCSK9
have been elucidated, in particular regarding its role in lipid metabolism, cardiovascular
risk but also its role in innate immunity. Increasing evidence is available on the involvement
of PCSK9 in the pathogenesis of viral infections, mainly HCV, as well as in the regulation
of host response to bacterial infections, mainly sepsis and septic shock. Moreover,
the action of PCSK9 has been investigated as a crucial step in the pathogenesis of malaria
infection and disease severity.

Objective:
Aim of this paper is to review available published literature on the role of
PCSK9 in a wide array of infectious diseases.

Conclusion:
Besides the ongoing investigation on PCSK9 inhibition among HIV-infected
patients for the treatment of HIV- and ART-related hyperlipidemia, preclinical studies indicate
how PCSK9 is involved in reducing the replication of HCV. Moreover, a protective
role of PCSK9 inhibition has also been proposed against dengue and SARS-CoV-2 viral
infections. Interestingly, high plasmatic PCSK9 levels have been described in patients
with sepsis. Finally, a loss of function in the PCSK9-encoding gene has been reported to
possibly reduce mortality in malaria infection.
Photo Cross-linkable Biopolymers for Cornea Tissue Healing
Authors: Nozari Negar , Biazar Esmaeil , Kamalvand Mahshad , Keshel Saeed Heidari , Shirinbakhsh Shervin 
Published: July 2021

:
Light can act as an effective and strong agent for the cross-linking of biomaterials and
tissues and is recognized as a safe substitute for chemical cross-linkers to modify mechanical and
physical properties and promote biocompatibility. This review focuses on the research about crosslinked
biomaterials with different radiation sources such as Laser or ultraviolet (UV) that can be applied
as scaffolds, controlled release systems,and tissue adhesives for cornea healing and tissue regeneration.
Penggunaan Limbah Sayur Pasar Dalam Pakan Crumble Dan Pengaruhnya Terhadap Penampilan Produksi Dan Mikroflora Usus Ayam Broiler
Authors: Santoso Erik Priyo , Fitasari Eka , Thiasari Nurita 
Published: July 2021

Tuntutan peningkatan sumber protein hewani terutama daging unggas menuntut ketersediaan pakan yang kontinyu, salah satunya adalah pemanfaatan limbah sayur pasar. Limbah ini jumlahnya banyak setiap harinya dan masih banyak yang belum termanfaatkan bahkan cenderung menimbulkan pencemaran lingkungan. Tujuan penelitian ini adalah mencari level terbaik penggunaan limbah sayur sebagai pakan ayam broiler yang memberikan peningkatan terhadap penampilan produksi dan kondisi microflora yang baik.Â Metode penelitian adalah menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan yaitu P1 (pakan control tanpa limbah sayur), P2 (penggunaan 5% limbah sayur dalam 100% formulasi pakan), P3 (penggunaan 10% limbah sayur dalam 100% formulasi pakan), P3 (penggunaan 15% limbah sayur dalam 100% formulasi pakan), dan P4 (penggunaan 20% limbah sayur dalam 100% formulasi pakan). Parameter yang diamati terdiri dari 2 kelompok yaitu terhadap penampilan produksi dan kondisi microflora usus.Â Hasil penelitian menghasilkan penggunaan pakan crumble ayam broiler berbasis limbah sayur memberikan pengaruh yang sangat nyata terhadap konsumsi, FCR, total TPC (p<0.01), serta peningkatan terhadap bobot badan dan jumlah bakteri asam laktat (BAL) dibandingkan dengan control. Penggunaan proporsi 15% limbah sayur memberikan peningkatan tertinggi terhadap konsumsi, pertambahan bobot badan, dan penurunan FCR, dan peningkatan terhadap BAL.
Produksi dan Kualitas Susu Sapi Friesian Holstein (FH) di Kpbs Pangalengan Kabupaten Bandung
Authors: Sudrajat Ajat , Saleh Dadang Mulyadi , Rimbawanto Efka Aris , Christi Raden Febrianto 
Published: July 2021

Penelitian ini bertujuan untuk mengkaji kinerja produksi dan kualitas susu. Metode penelitian menggunakan metode survey, pengambilan data dilakukan secara purposive sampling dengan kriteria sapi perah yang sudah laktasi dan melakukan sampling pada 47 responden.Variabel yang dianalisa adalah produksi susu dan kualitas susu yang meliputi kadar fat, solid non fat, freezing point, protein maupun total plate count. Analisis data dilakukan secara deskriptif dan analisis statistik mengunakan uji LSD. Hasil penelitian menunjukan bahwaÂ rata-rata produksi susu di KPBS Pangalengan tidak berbeda nyata (P<0,05) antara kelompokA (9,83 kg/ekor/hari), kelompok B (9,13 kg/ekor/hari) dan kelompok C (8,62 kg/ekor/hari). Rerata kualitas susu yang menunjukan berbeda nyata (P<0,05) adalah pada kadar fat (kelompok A 4,02%; kelompok B 3,97% dan Kelompok C 3,71%),kadar freezing point (kelompok A -0,506; kelompok B -0,0523 dan kelompok C -0,520) dan total plate count (kelompok A 0,48 x106 CFU/ml, kelompok B 1,99 x106 Â CFU/ml dan kelompok C 2,78 x106 CFU/ml). Rerata kualitas susu yang menunjukan tidak berbeda nyata(P>0,05) adalah kadar protein susu (kelompok A 2,97%; kelompok B 3,08% dan kelompok C 2,94%) dan kadar solid non fat (kelompok A 8,09%; kelompok B 7,92% dan Kelompok C 7,86%). Kesimpulan penelitian ini adalah produksi susu di KPBS Pangalengan relatif hampir sama, mempunyai kualitas susu diatas SNI (2011), kecuali jumlah total plate count masih diatas SNI.
Evaluation of the Acceptability of a Proposed, Instagram-Based, Randomized Controlled Trial for People With Asthma: Survey Study
Authors: Spitzer Kerry A , Heineman Brent , Jewell Marcella , Moran Michael , Lindenauer Peter K 
Published: July 2021

Background
Asthma is a chronic lung disease that affects nearly 25 million individuals in the United States. More research is needed into the potential for health care providers to leverage existing social media platforms to improve healthy behaviors and support individuals living with chronic health conditions.

Objective
In this study, we assessed the willingness of Instagram users with poorly controlled asthma to participate in a pilot randomized controlled trial that will use Instagram as a means of providing social and informational support. In addition, we explored the potential for adapting the principles of photovoice and digital storytelling to Instagram.

Methods
We conducted a survey study of Instagram users aged 18-40 years with poorly controlled asthma in the United States.

Results
Over 3 weeks of recruitment, 457 individuals completed the presurvey screener; 347 (75.9%) were excluded and 110 (24.1%) were eligible and agreed to participate in the study. Of the 110 individuals, 82 (74.5%) completed the study survey. The mean age of the respondents was 21 (SD 5.3) years. Among respondents, 56% (46/82) were female, 65% (53/82) were non-Hispanic White, and 72% (59/82) had at least some college education. The majority of respondents (67/82, 82%) indicated that they would be willing to participate in the proposed study.

Conclusions
Among young adult Instagram users with asthma, there is substantial interest in participating in a pilot randomized controlled trial that will use Instagram to connect participants with peers and a health coach to share information about self-management of asthma and build social connection.