bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Modulatory Role of Internet-Supported Mindfulness-Based Cognitive Therapy on Extracellular Vesicles and Psychological Distress in People Who Have Had Cancer: A Protocol for A Two-Armed Randomized Controlled Study
Authors: Pereira Diana , Silva Eunice R. , Carvalho-Maia Carina , Monteiro-Reis Sara , Lourenço Catarina , Calisto Rita , Teixeira Ricardo João , Carlson Linda E. , Bart Genevieve , Vainio Seppo J. , Sales M. Goreti F. , Jerónimo Carmen , Henrique Rui 
Published: December 2021

Abstract
BackgroundMindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) have examined their effects upon biological parameters. Specifically, no previous study has examined the effects of MBIs on extracellular vesicles (EVs), which are potentially important markers of health, disease, and stress. Moreover, the lack of RCTs is even more limited within the context of technology-mediated MBIs and long-term effects.MethodsThe current study protocol presents a two-arm, parallel, randomized controlled study investigating the effects of internet-supported mindfulness-based cognitive therapy (MBCT) compared with treatment as usual (TAU). Primary outcomes are psychological distress and EV cargo of distressed participants with previous breast, colorectal, or prostate cancer diagnoses. Secondary outcomes are self-reported psychosocial and health-related measures, and additional biological markers. Outcomes will be assessed at baseline, 4 weeks after baseline (mid-point of the intervention), 8 weeks after baseline (immediately post-intervention), 24 weeks after baseline (after booster sessions), and 52 weeks after baseline. Our goal is to recruit at least 111 participants who have been diagnosed with breast, prostate, or colorectal cancer (cancer stage I to III), are between 18 and 65 years old, and have had primary cancer treatments completed between 3 months and 5 years ago. Half of the participants will be randomized to the TAU group and the other half will participate in an 8-week online MBCT intervention with weekly group sessions via videoconference. The intervention also includes asynchronous homework, an online retreat after the fifth week, and 4 monthly booster sessions after completion of the 8-week program.DiscussionThis study will allow characterizing the effects of internet-based MBCT on psychosocial and biological indicators in the context of cancer. The effects on circulating EVs will also be investigated, as a possible neurobiological pathway underlying mind-body intervention effects. Trial registration: NCT04727593 (date of registration: 27 January 2021; date of record verification: 6 October 2021; https://clinicaltrials.gov/ct2/show/NCT04727593).
PREÇOS DOS IMÓVEIS EM NATAL-RN: BOLHA E CONTANGO NO PERÍODO 2005-2010
Authors: Bezerra Márcia Maria de Oliveira , Correa André Luíz , Mendonça Ana Rosa Ribeiro de , Clementino Maria do Livramento Miranda 
Published: December 2021

À luz da abordagem de Davidson, a dinâmica de preços dos imóveis em Natal comporta fenômenos que merecem ser tratados. No período 2005-2007, observa-se uma situação de backwardation, cuja intensidade fornece evidências suficientes da ocorrência de uma bolha imobiliária na cidade. Após 2008, é possível identificar uma situação de contango diferente, percepção esta reforçada pelo movimento dos outros indicadores considerados na pesquisa referentes à comparação entre a evolução do valor dos aluguéis e a trajetória dos preços dos imóveis e à evolução do indicador de preço e custo da construção. Esse artigo explora a possibilidade do tipo de contango observado permitir que o tratamento de bolhas, sustentado na perspectiva teórica desenvolvida por Davidson, capte o ponto de inflexão desse fenômeno, ou seja, da possível passagem do movimento ascendente de preços em direção ao seu processo de arrefecimento.
Veinte años de dictadura
Authors: Amézola Gonzalo 
Published: December 2021

Desde el inicio de la reforma educativa en Argentina, la enseñanza de la historia en la escuela secundaria se centró en la época contemporánea. En este contexto el objetivo de formar ciudadanos democráticos se concentró en el estudio de la trágica experiencia vivida con la última dictadura militar (1976 – 1983). Así fue como la dictadura se fue instalando firmemente como un tema escolar en la enseñanza media desde 1993, lo que habilita algunas preguntas: ¿Cuáles son las características de esa enseñanza? ¿Qué se propone y qué logra efectivamente la escuela con el estudio de la dictadura? Buscaremos indicios para esas cuestiones en el análisis de la normativa oficial, en la propuesta editorial y los saberes de los estudiantes a través de los datos relevados en casi mil encuestas.
Repeated Administration of Orexin into the Thalamic Paraventricular
Nucleus Inhibits the Development of Morphine-Induced Analgesia
Authors: Samani Fatemeh , Arami Masoumeh Kourosh 
Published: December 2021

Background:
Hypothalamic neuropeptides, orexins, play pivotal roles in nociception
and pain modulation.

Objective:
In this study, we investigated the effect of the administration of orexin into the paraventricular
nucleus (PVT) on the development of morphine-induced analgesia in rats.

Methods:
Male Wistar rats weighing 250-300g received subcutaneous (s.c.) chronic morphine (6,
16, 26, 36, 46, 56 and 66 mg/kg, 2 ml/kg) at an interval of 24 hours for 7 days. Animals were divided
into two experimental groups in which the orexin (100 μM, 200 nl) and its vehicle were microinjected
into the PVT nucleus for 7 days before each morphine injection. Then, the formalin test was
performed for the assessment of pain-related behaviors.

Results:
The results demonstrated that the rats pretreated by intra-PVT orexin exhibited higher
pain-related behaviors than the morphine-treated group. The analgesic effects of morphine were significantly
lower in orexin plus morphine-treated rats than the vehicle plus morphine-treated ones.

Conclusion:
Our findings suggested that the animals receiving the prolonged intra-PVT application
of orexin before morphine injection demonstrated a significant increase in the development of
nociceptive behaviors in all phases. There fore, the present study highlighted a new area of the
brain involved in the effect of orexin on analgesia induced by morphine.
Indazole and its Derivatives in Cardiovascular Diseases: Overview,
Current Scenario, and Future Perspectives
Authors: Uppulapu Shravan Kumar , Alam Md. Jahangir , Kumar Santosh , Banerjee Sanjay Kumar 
Published: December 2021

:
Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.
The Attitudes of Egyptian Web-Based Health Information Seekers Toward Health Information Provided Through the Internet: Qualitative Study
Authors: Ghweeba Mayada , Lindenmeyer Antje , Shishi Sobhi , Waheed Amani , Kofi Mostafa , Amer Shaymaa 
Published: December 2021

Background
The internet has become an established source of health information for many Egyptian internet users. Understanding users’ attitudes toward the benefits and limitations of web-based health information will explain the influence of this information on users’ health-related behavior and decisions.

Objective
This qualitative study aims to understand the attitude of Egyptian internet users toward internet health information and to explore the impact of obtained health information on users’ behavior and on their physician-patient relationship.

Methods
For this qualitative study, semistructured interviews were conducted with a total of 49 participants (41/49, 84% Egyptian internet users and 8/49, 16% physicians) who participated in focus groups or individual interviews. We used a thematic analysis approach to explain and demonstrate participants’ views, thoughts, and experiences in using web-based health information.

Results
The internet has become an important source of health information in comparison with other health information sources and is the central theme that has emerged across the thematic analysis. The attitude toward the use of internet health was classified into three main themes: feeling toward web-based health information (with subthemes: favoring, disliking, neutral, or having ambivalence feelings), motivators to seek internet health information, and behavioral changes using internet health information (subthemes: confidence, satisfaction, and improved knowledge). Themes that emerged from physicians’ interviews included the accessibility of the internet health information, good communication, and coordination of care between patients and their physicians, and the active engagement of patients with their management plan.

Conclusions
The internet has become an essential source of health information for Egyptian adults. Internet health information can improve the patient-physician relationship, especially when users discuss the obtained health information with their physician. Internet health information provided seekers with social support and self-confidence when making health decisions.
Economics of implementing an early deterioration detection solution for general care patients at a US hospital
Authors: Mohr Belinda A , Bartos Diane , Dickson Stephen , Bucsi Libby , Vente Mariska , Medic Goran 
Published: December 2021

Aim:
This study estimates the costs and outcomes pre- versus post-implementation of an early deterioration detection solution (EDDS), which assists in identifying patients at risk of clinical decline.
Materials & methods:
A retrospective database analysis was conducted to assess average costs per discharge, length of stay (LOS), complications, in-hospital mortality and 30-day all-cause re-admissions pre- versus post-implementation of an EDDS.
Results:
Average costs per discharge were significantly reduced by 18% (US$16,201 vs $13,304; p
=
0.007). Average LOS was also significantly reduced (6 vs 5 days; p
=
0.033), driven by a reduction in general care LOS of 1 day (p
=
0.042). Complications, in-hospital mortality and 30-day all-cause re-admissions were similar.
Conclusion:
Costs and LOS were lower after implementation of an EDDS for general care patients.
La perspectiva ética en los comentarios del cardenal Cayetano
Authors: Lázaro Nicolás 
Published: December 2021

Este trabajo presenta el cambio de perspectiva ética que se advierte en los comentarios de Cayetano a S. Th. II-II, qq. 57-62. Además de la distancia lógico-filosófica con Tomás (quien define la virtud de la justicia con analogía de atribución intrínseca), Cayetano (que lo hace con concepto unívoco) realiza un viraje de una ética de la virtud (o en primera persona) hacia una ética de la obligación (o en tercera persona), a través de la prescripción y la obediencia (formalismo, voluntarismo). El saldo de aquella distancia con Tomás de Aquino no es sólo la triespecificación de la justicia (que también presentamos, junto con sus implicancias teóricas y prácticas), sino además el camino abierto que deja a posteriores corrientes filosófico-políticas que terminarán por generar reflexiones de corte liberal dentro de la misma Escuela. Si bien no nos ocuparemos de ellas aquí, sí ponemos uno de los hitos que las ha favorecido: el cambio de perspectiva ética en la glosa cayetana.
La constitución de la subjetividad desde la interdependencia y los desafíos socioecológicos del siglo XXI: una aproximación desde Dōgen
Authors: Barbosa Cepeda Carlos 
Published: December 2021

En el presente artículo, argumentaremos que es posible encontrar en el clásico filósofo y maestro zen japonés Eihei Dōgen (1200-1253) una muy significativa contribución a nuestros esfuerzos por enfrentar la problemática ambiental y social de nuestro tiempo. Esta contribución consiste en una perspectiva a partir de la cual sea posible reconectar la subjetividad humana con el entorno y con los otros. Así, sería posible superar la tendencia del sujeto moderno al autoconfinamiento (cerrarse sobre sí mismo), tendencia que está en la raíz de realidades que han alimentado la crisis socioambiental en nuestra era, como el individualismo en general, y el consumismo en particular. Para desarrollar la idea central del texto, procederemos en cuatro pasos. Primeramente, precisaremos el sentido del autoconfinamiento al que tiende la subjetividad moderna y su carácter de condición esencial para la emergencia de la crisis socioambiental que actualmente enfrenta la humanidad. Enseguida, examinaremos la salida del autoconfinamiento desde Dōgen y cómo a partir de él se puede configurar una forma de subjetividad conectada: el sujeto se configura no en oposición al resto de la realidad, sino en radical conexión y sintonía con la realidad circundante. En tercer lugar, mostraremos que la sintonía en la base de la subjetividad conectada se puede evidenciar en la experiencia estética del ambiente: el apercibirse concretamente del ambiente es la ocasión para que el individuo descubra quién es. Finalmente, desde tal perspectiva sugeriremos eventuales vías para poner en acto esta constitución conectada de la subjetividad que permitan afrontar la crisis socioambiental.
Piedras. Construir itinerarios, avizorar intersticios
Authors: Guevara Aristizabal Juan Felipe 
Published: December 2021

Las piedras pueden ser usadas para marcar recorridos y rutas para el pensamiento. Este itinerario está compuesto por cuatro piedras que configuran un terreno de contrastes. La primera pone el contraste entre lo vivo y lo no vivo como punto de partida en el cual la delicada interfaz entre esos dos mundos queda suspendida y puesta en entredicho. Aquí emerge el concepto de agencia como aspecto confuso y problemático. La segunda piedra se desplaza al contraste entre la construcción humana y la construcción geológica, las cuales se encuentran unidas por diferentes acepciones de lo tectónico. El poder móvil de las piedras afinca la tercera piedra en la cual se presentan concepciones ‘premodernas’ del ingenio del paisaje en la geografía y una de las manifestaciones de la productividad de las piedras en los minerales. La extracción de estos últimos pone de manifiesto la íntima relación que hay entre las piedras y la discriminación sobre ciertos grupos humanos, de modo que la cuarta piedra expone la paradoja que se cierne sobre el contraste entre lo interior y lo exterior. Esta última piedra regresa sobre el concepto de agencia para enfatizar uno de sus rasgos turbios. Cada una de las piedras envuelve intersticios entre los cuales fluye una forma de pensamiento que bien podría llamarse la de una ontología minúscula.
El mundo expresado intersubjetivamente: un puente entre Nishida y Husserl
Authors: Alvarado Grecco Daniel Salvador 
Published: December 2021

En lo que sigue me propongo trazar un vínculo entre los planteamientos de Nishida y Husserl en lo que respecta la intersubjetividad. Si bien hay diferencias importantes entre estos autores, encuentro que coinciden en el tratamiento del mundo expresado intersubjetivamente, es decir, aprehendido por una multiplicidad de individuos. Para demostrar lo anterior, me centraré en los aspectos que hacen casi imposible cualquier tentativa de vincular los planteamientos de los dos, a saber, el hecho de que Nishida y Husserl parecen ir en distintas direcciones debido al uso de conceptos como ‘experiencia pura’, ‘reducción fenomenológica’ y epojé. Sugiero, sin embargo, que estas diferencias deben ser examinadas a partir de las observaciones de “The Logic of Topos” —Nishida— y Meditaciones cartesianas —Husserl—. A mi parecer, la coincidencia ha de ser encontrada en estos textos, ya que los dos ofrecen la idea de un mundo expresado a través de la aprehensión del mundo del individuo. Mis conclusiones intentarán ampliar el alcance de este artículo al sugerir algunos vínculos entre Nishida y la obra fenomenológica de Jacques Derrida, cuyo trabajo intentó poner la cuestión de la alteridad al centro de la fenomenología.
Homicidio Policial, Víctimas e Impunidad. Tres nociones para pensar la Violencia Estatal en su radicalidad
Authors: Chena Marina , Fernández Natalia , Miretti Jeremías , Molas y Molas María , Petiti Yanina , Valenzuela Héctor 
Published: December 2021

Son diversos los puntos críticos que nos interpelan en el quehacer profesional como psicólogos/as frente a las políticas de seguridad de un Estado Policial fuertemente represivo y que tiene a los jóvenes de sectores populares como blanco predilecto en la Provincia de Córdoba. Nos propusimos construir un dispositivo específico de intervención que dio origen al Equipo de Acompañamiento a Familiares de Jóvenes asesinados por la Policía. En este camino de consolidación del dispositivo, resultan relevantes los anclajes conceptuales para pensar la intervención. En este trabajo nos proponemos problematizar tres nociones que insisten ser pensadas: homicidio policial, el concepto de víctima y la cuestión de la impunidad que prevalecen incluso en un estado democrático. Estas categorías operan como ejes que orientan la presente reflexión y buscan dar cuenta del proceso de construcción de nuestros fundamentos tanto ético-políticos como teórico-prácticos. Palabras clave: Violencia estatal, homicidio policial, víctimas, impunidad.
Can Severity of Pulmonary Hypertension Affect Success Rate of Balloon Mitral Commissurotomy?
Authors: Galeshi Bahar , Shojaeifard Maryam , Farrashi Melody , Ganji Hanifeh , Erami Sajad , Ghadrdoost Behshid 
Published: December 2021

Introduction: Rheumatic heart disease is responsible for the
most prevalent pathological causes of mitral stenosis and is closely
coupled with pulmonary hypertension. Balloon mitral commissurotomy as an
alternative method for mitral valve replacement leads to a reduction in
pulmonary pressure. All grades of pulmonary hypertension usually regress
after mitral commissurotomy; however, the insignificant changes of
pulmonary artery hypertension following balloon mitral valvuloplasty are
not uncommon. Methods: This retrospective observational study
was carried out on 160 patients with significant symptomatic mitral
stenosis (mitral valve area [MVA] <1.5 cm
) who underwent successful percutaneous transvenous
mitral commissurotomy (PTMC) within 2016-2020 at Shaheed Rajaie
Cardiovascular, Medical and Research Center, Tehran, Iran.
Results: In this study, 89.4% of the patients were female, and
the mean age of the participants was 47.2±12.4 years. Most (74%)
patients presented with dyspnea on exertion functional class II. The
mean basic MVA was 1±0.20 cm that increased to
1.43±0.23 cm , and the mean basic systolic pulmonary
artery pressure (PAP) was 43.84±11.93 mmHg that decreased to 35.13±7.7
mmHg. Persistent PAP after successful PTMC was observed in 34% of the
patients. This group of patients showed smaller MVA gain and PAP
reduction after the procedure. Pulmonary vascular resistance (PVR)
> 2 Wood units was correlated to 91.7% of the
post-procedural success rate. Conclusion: The PTMC plays an
important role in the reduction of PAP; nevertheless, the chronicity and
severity of PAP can lead to persistent pulmonary hypertension. The
assessment of initial PAP and basic PVR can help select patients with
more likely intended results.
Kebijakan Pemangkasan Struktur Birokrasi di Indonesia
Authors: Rohman M Najibur , Rismana Daud 
Published: December 2021

This article aims to find out the policy formulation of reducing the bureaucratic structure in Indonesia and the impact that occurs as its result. This article is a literature research using literature review as a primary legal source supported by secondary data which is the result of implementing regulations in the field. The results of the study indicate that the formulation of the policy of reducing the bureaucratic structure in Indonesia is to eliminate echelon III to echelon V. The main purpose of this cut is to streamline government services through government employees (civil servants). As the impact, organizationally, this cut is not ideal because it is carried out in parallel with the preparation of SOTK. In terms of human resource management, this cut has an impact on the transfer of administrative officials to functional positions that are more competency-based or expertise-based.
Growth of tench (Tinca tinca L., 1758) (Cyprinidae) in reservoirs of K. Satpayev canal
Authors: Krainyuk Vladimir Nickolaevich , Asylbekova Saule Zhangirovna , Shutkarayev Azis Vasilyevich 
Published: December 2021

The reservoirs of the K. Satpayev canal are the important fishery water bodies in the Central Kazakhstan. Some of these reservoirs are inhabited by tench, a fish species relatively widely represented in other water systems of the region. In the reservoirs of the canal this species is not the main commercial one but it has a fairly high commercial value due to its popularity with consumers. As part of the research, the growth indicators of Tinca tinca from
4 reservoirs were evaluated, and the data on its growth from 3 more reservoirs were also provided. These samples differ in efficiency and growth rates. It has been found that there is no sexual or generation variability. Growth rates in successive fish generations strongly correlate with each other, which may indirectly indicate the stability of living conditions. The R. Lee’s phenomenon was not marked. In this regard, the calculation of variables of the von Bertalanffy growth equation was carried out without additional data processing. The highest rates of linear growth were characteristic of Tinca tinca from the reservoir of HS No. 9. However, the effectiveness of its growth scheme was the lowest. Population with a longer age range from the reservoir HS No. 3 did not have high linear growth rates, but its growth efficiency was higher. In this case, it is obvious that any assessment of growth will be relative and depend on the goals set for it. In the reservoirs of the canal there are more or less similar conditions for tench populations living due to the specifics of its functioning. The main limiting factor for the growth rate, in our opinion, will be abundance of the species in the reservoir and related trophic factors with a certain influence of withdrawal (fishing, predators).