bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role Of the Sun and the Middle atmosphere/thermosphere/ionosphere In Climate (ROSMIC): a retrospective and prospective view
Authors: Ward William , Seppälä Annika , Yiğit Erdal , Nakamura Takuji , Stolle Claudia , Laštovička Jan , Woods Thomas N. , Tomikawa Yoshihiro , Lübken Franz-Josef , Solomon Stanley C. , Marsh Daniel R. , Funke Bernd , Pallamraju Duggirala 
Published: August 2021

AbstractWhile knowledge of the energy inputs from the Sun (as it is the primary energy source) is important for understanding the solar-terrestrial system, of equal importance is the manner in which the terrestrial part of the system organizes itself in a quasi-equilibrium state to accommodate and re-emit this energy. The ROSMIC project (2014–2018 inclusive) was the component of SCOSTEP’s Variability of the Sun and Its Terrestrial Impact (VarSITI) program which supported research into the terrestrial component of this system. The four themes supported under ROSMIC are solar influence on climate, coupling by dynamics, trends in the mesosphere lower thermosphere, and trends and solar influence in the thermosphere. Over the course of the VarSITI program, scientific advances were made in all four themes. This included improvements in understanding (1) the transport of photochemically produced species from the thermosphere into the lower atmosphere; (2) the manner in which waves produced in the lower atmosphere propagate upward and influence the winds, dynamical variability, and transport of constituents in the mesosphere, ionosphere, and thermosphere; (3) the character of the long-term trends in the mesosphere and lower thermosphere; and (4) the trends and structural changes taking place in the thermosphere. This paper reviews the progress made in these four areas over the past 5 years and summarizes the anticipated research directions in these areas in the future. It also provides a physical context of the elements which maintain the structure of the terrestrial component of this system. The effects that changes to the atmosphere (such as those currently occurring as a result of anthropogenic influences) as well as plausible variations in solar activity may have on the solar terrestrial system need to be understood to support and guide future human activities on Earth.
Single implant-supported two-unit cantilever fixed partial dentures in the posterior region: a retrospective case series with a mean follow-up of 6.5 years
Authors: Jensen-Louwerse Charlotte , Sikma Harjan , Cune Marco S. , Guljé Felix L. , Meijer Henny J. A. 
Published: August 2021

Abstract
Background
The aim of this retrospective study was to evaluate the implant survival, clinical and radiographic outcomes, and patient satisfaction of single implant-supported two-unit cantilever fixed partial dentures in the posterior region.

Methods
Patients who received a single implant-supported fixed partial denture with a cantilever in the posterior region between January 2004 and February 2018 were included. Survival rate of the implants and the fixed partial dentures and data regarding the marginal bone level, presence of plaque, calculus, bleeding on probing, mucosa health, pocket probing depth, and patient satisfaction were collected during an evaluation visit. Complications were recorded from the medical records.

Results
Twenty-three patients (mean age 64 ± 13 years) with 28 implants could be included in the study. The mean follow-up period was 6.5 ± 4.8 years at the time of data collection. The survival rate of the implants and fixed partial dentures was 100%. Mean marginal bone loss for the mesial and distal side of the implants was 0.41 mm (SD 1.18 mm) and 0.63 mm (SD 0.98 mm) respectively. A high prevalence of peri-implant-mucositis (89.3%) and peri-implantitis (17.9%) was observed as well as a limited number of technical complications. Patients were quite satisfied, as reflected by a mean VAS score of 94.0 ± 7.2 points (range 0–100) and a OHIP-NL49 score of 10.8 (range 0–196).

Conclusions
Single implant-supported fixed partial dentures with a mesial or distal cantilever can be a predictable treatment option in the posterior region, with stable peri-implant bone levels, minor technical complications, and very content patients. However, the prevalence of peri-implant mucositis and peri-implantitis was high.

Trial registration
ISRCTN, ISRCTN79055740, Registered on March 14, 2021 – —Retrospectively registered.
Planning and optimising a digital intervention to protect older adults’ cognitive health
Authors: Essery Rosie , Pollet Sebastien , Smith Kirsten A. , Mowbray Fiona , Slodkowska-Barabasz Joanna , Denison-Day James , Hayter Victoria , Bradbury Katherine , Grey Elisabeth , Western Max J. , Milton Alexander , Hunter Cheryl , Ferrey Anne E. , Müller Andre Matthias , Stuart Beth , Mutrie Nanette , Griffin Simon , Kendrick Tony , Brooker Helen , Gudgin Bernard , Phillips Rosemary , Stokes Tom , Niven John , Little Paul , Yardley Lucy 
Published: August 2021

Abstract
Background
By 2050, worldwide dementia prevalence is expected to triple. Affordable, scalable interventions are required to support protective behaviours such as physical activity, cognitive training and healthy eating. This paper outlines the theory-, evidence- and person-based development of ‘Active Brains’: a multi-domain digital behaviour change intervention to reduce cognitive decline amongst older adults.

Methods
During the initial planning phase, scoping reviews, consultation with PPI contributors and expert co-investigators and behavioural analysis collated and recorded evidence that was triangulated to inform provisional ‘guiding principles’ and an intervention logic model. The following optimisation phase involved qualitative think aloud and semi-structured interviews with 52 older adults with higher and lower cognitive performance scores. Data were analysed thematically and informed changes and additions to guiding principles, the behavioural analysis and the logic model which, in turn, informed changes to intervention content.

Results
Scoping reviews and qualitative interviews suggested that the same intervention content may be suitable for individuals with higher and lower cognitive performance. Qualitative findings revealed that maintaining independence and enjoyment motivated engagement in intervention-targeted behaviours, whereas managing ill health was a potential barrier. Social support for engaging in such activities could provide motivation, but was not desirable for all. These findings informed development of intervention content and functionality that appeared highly acceptable amongst a sample of target users.

Conclusions
A digitally delivered intervention with minimal support appears acceptable and potentially engaging to older adults with higher and lower levels of cognitive performance. As well as informing our own intervention development, insights obtained through this process may be useful for others working with, and developing interventions for, older adults and/or those with cognitive impairment.
Knowledge guides attention to goal-relevant information in older adults
Authors: Smith Maverick E. , Loschky Lester C. , Bailey Heather R. 
Published: August 2021

AbstractHow does viewers’ knowledge guide their attention while they watch everyday events, how does it affect their memory, and does it change with age? Older adults have diminished episodic memory for everyday events, but intact semantic knowledge. Indeed, research suggests that older adults may rely on their semantic memory to offset impairments in episodic memory, and when relevant knowledge is lacking, older adults’ memory can suffer. Yet, the mechanism by which prior knowledge guides attentional selection when watching dynamic activity is unclear. To address this, we studied the influence of knowledge on attention and memory for everyday events in young and older adults by tracking their eyes while they watched videos. The videos depicted activities that older adults perform more frequently than young adults (balancing a checkbook, planting flowers) or activities that young adults perform more frequently than older adults (installing a printer, setting up a video game). Participants completed free recall, recognition, and order memory tests after each video. We found age-related memory deficits when older adults had little knowledge of the activities, but memory did not differ between age groups when older adults had relevant knowledge and experience with the activities. Critically, results showed that knowledge influenced where viewers fixated when watching the videos. Older adults fixated less goal-relevant information compared to young adults when watching young adult activities, but they fixated goal-relevant information similarly to young adults, when watching more older adult activities. Finally, results showed that fixating goal-relevant information predicted free recall of the everyday activities for both age groups. Thus, older adults may use relevant knowledge to more effectively infer the goals of actors, which guides their attention to goal-relevant actions, thus improving their episodic memory for everyday activities.
COVID-19 clinical and laboratory diagnosis overview
Authors: Zayed Rania A. , Omran Dalia , Zayed Abeer A. 
Published: August 2021

Abstract
Background
COVID-19 was identified in Wuhan, China, in December 2019, and rapidly spread worldwide, being declared global pandemic on the 11th of March 2020. Since its emergence, COVID-19 has raised global concerns associated with drastic measures that were never adopted in any previous outbreak, to contain the situation as early as possible.

Main body
The 2019 novel corona virus (2019-nCoV) or SARS-CoV-2 is the causative agent of COVID-19. 2019-nCoV genetic sequence was rapidly identified within few days since the first reported cases and RT-PCR kits became available for COVID-19 diagnosis. However, RT-PCR diagnosis carries a risk of false-negative results; therefore, additional serologic tests are needed. In this review, we summarize the clinical scenario that raises suspicion of COVID-19 and available laboratory diagnostics.

Conclusion
The most important approach in the battle against COVID-19 is rapid diagnosis of suspicious cases, timely therapeutic intervention and isolation to avoid community spread. Diagnosis depends mainly on PCR testing and serological tests. However, even in the context of negative lab test results and clinical suspicion of COVID-19 infection, clinical decision should be based on clinical suspicion.
Tilted platforms: rental housing technology and the rise of urban big data oligopolies
Authors: Boeing Geoff , Besbris Max , Wachsmuth David , Wegmann Jake 
Published: August 2021

Abstract
This article interprets emerging scholarship on rental housing platforms—particularly the most well-known and used short- and long-term rental housing platforms—and considers how the technological processes connecting both short-term and long-term rentals to the platform economy are transforming cities. It discusses potential policy approaches to more equitably distribute benefits and mitigate harms. We argue that information technology is not value-neutral. While rental housing platforms may empower data analysts and certain market participants, the same cannot be said for all users or society at large. First, user-generated online data frequently reproduce the systematic biases found in traditional sources of housing information. Evidence is growing that the information broadcasting potential of rental housing platforms may increase rather than mitigate sociospatial inequality. Second, technology platforms curate and shape information according to their creators’ own financial and political interests. The question of which data—and people—are hidden or marginalized on these platforms is just as important as the question of which data are available. Finally, important differences in benefits and drawbacks exist between short-term and long-term rental housing platforms, but are underexplored in the literature: this article unpacks these differences and proposes policy recommendations.

Policy and practice recommendations

As rental housing technologies upend traditional market processes in favor of platform oligopolies, policymakers must reorient these processes toward the public good.

Long-term and short-term rental platforms offer different market benefits and drawbacks, but the latter in particular requires proactive regulation to mitigate harm.

At a minimum, policymakers must require that short-term rental platforms provide the information necessary for cities to enforce current, let alone new, housing regulations.

Practitioners should be cautious inferring market conditions from rental housing platform data, due to difficult-to-measure sampling biases.
mPalliative Care Link: Examination of a Mobile Solution to Palliative Care Coordination Among Tanzanian Patients With Cancer
Authors: Ngoma Mamsau , Mushi Beatrice , Morse Robert S. , Ngoma Twalib , Mahuna Habiba , Lambden Kaley , Quinn Erin , Sagan Sarah B. , Ho Yun Xian , Lucas F. Lee , Mmari Joshua , Miesfeldt Susan 
Published: August 2021

PURPOSE Late-stage cancer patient symptom control is a national priority in Tanzania. Mobile health promises to improve the reach of a limited pool of palliative care specialists through interprofessional, community-based care coordination. This work assessed the effectiveness of a smartphone- or Web-based app, mPalliative Care Link (mPCL), to extend specialist access via shared data and communication with local health workers. Central to mPCL is the African Palliative care Outcome Scale (POS), adapted for automated mobile symptom assessment and response. METHODS Adult patients with incurable cancer were randomly assigned at hospital discharge to mPCL versus phone-contact POS collection. Sociodemographic, clinical, and POS data were obtained at baseline. Twice-weekly POS responses were collected and managed via mPCL or phone contact with clinician study personnel for up to 4 months, on the basis of study arm assignment. Patient end-of-study care satisfaction was assessed via phone survey. RESULTS Forty-nine patients per arm participated. Comparison of baseline characteristics showed an insignificant trend toward more women ( P = .07) and higher discharge morphine use ( P = .09) in the mPCL group compared with phone-contact and significant between-group differences in cancer types ( P = .003). Proportions of deaths were near equal between groups (mPCL: 27%; phone-contact: 29%). Overall symptom severity was significantly lower in the phone-contact group ( P < .0001), and symptom severity decreased over time in both groups ( P = .0001); however, between-group change in overall symptoms over time did not vary significantly ( P = .34). Care satisfaction was generally high in both groups. CONCLUSION Higher symptom severity scores in the mPCL arm likely reflect between-group sociodemographic and clinical differences and clinical support of phone-contact arm participants. Similar rates of care satisfaction in both groups suggest that mPCL may support symptom-focused care coordination in a more efficient and scalable manner than phone contact. A broader study of mPCL's cost efficiency and utility in Tanzania is needed.
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804
Authors: McCormick Beryl , Winter Kathryn A. , Woodward Wendy , Kuerer Henry M. , Sneige Nour , Rakovitch Eileen , Smith Barbara L. , Germain Isabelle , Hartford Alan C. , O'Rourke Mark A. , Walker Eleanor M. , Strom Eric A. , Hopkins Judith O. , Pierce Lori J. , Pu Anthony T. , Sumida Kenneth N. M. , Vesprini Danny , Moughan Jennifer , White Julia R. 
Published: August 2021

PURPOSE To our knowledge, NRG/RTOG 9804 is the only randomized trial to assess the impact of whole breast irradiation (radiation therapy [RT]) versus observation (OBS) in women with good-risk ductal carcinoma in situ (DCIS), following lumpectomy. Long-term results focusing on ipsilateral breast recurrence (IBR), the primary outcome, are presented here. PATIENTS AND METHODS Eligible patients underwent lumpectomy for DCIS that was mammogram detected, size ≤ 2.5 cm, final margins ≥ 3 mm, and low or intermediate nuclear grade. Consented patients were randomly assigned to RT or OBS. Tamoxifen use was optional. Cumulative incidence was used to estimate IBR, log-rank test and Gray's test to compare treatments, and Fine-Gray regression for hazard ratios (HRs). RESULTS A total of six hundred thirty-six women were randomly assigned from 1999 to 2006. Median age was 58 years and mean pathologic DCIS size was 0.60 cm. Intention to use tamoxifen was balanced between arms (69%); however, actual receipt of tamoxifen varied, 58% RT versus 66% OBS ( P = .05). At 13.9 years' median follow-up, the 15-year cumulative incidence of IBR was 7.1% (95% CI, 4.0 to 11.5) with RT versus 15.1% (95% CI, 10.8 to 20.2) OBS ( P = .0007; HR = 0.36; 95% CI, 0.20 to 0.66); and for invasive LR was 5.4% (95% CI, 2.7 to 9.5) RT versus 9.5% (95% CI, 6.0 to 13.9) OBS ( P = .027; HR = 0.44; 95% CI, 0.21 to 0.91). On multivariable analysis, only RT (HR = 0.34; 95% CI, 0.19 to 0.64; P = .0007) and tamoxifen use (HR = 0.45; 95% CI, 0.25 to 0.78; P = .0047) were associated with reduced IBR. CONCLUSION RT significantly reduced all and invasive IBR for good-risk DCIS with durable results at 15 years. These results are not an absolute indication for RT but rather should inform shared patient-physician treatment decisions about ipsilateral breast risk reduction in the long term following lumpectomy.
How to Effectively Decrease Patient Co-Payments of High-Cost Drugs Through Innovation: Lessons From the Karmanos Specialty Pharmacy
Authors: Seymour Erlene K. , Daniel Lucius , Pointer Eva , Julian Jordan , Smith Stephen T. , Schiffer Charles A. 
Published: August 2021

PURPOSE: High-cost drugs impose a financial burden on patients with cancer. Karmanos Specialty Pharmacy (KSP) developed a process to automate financial assistance (FA) applications to decrease patient drug cost. We evaluate the outcomes of this program on cost to patients and payers. METHODS: This is an observational, retrospective study of the KSP claims data set from January to December 2019, accessed by 13 statewide cancer centers within Michigan. Drug cost of patients, payers, FA (funds to lower patient drug cost), and types of FA were obtained. A subset analysis was performed to determine drug delivery times. RESULTS: In 2019, 869 prescriptions and 1,722 prescription fills were provided to 463 patients through KSP. The total cost of drug claims was approximately $10 million US dollars (USD) among Medicare patients (58%), approximately $3.4 million USD for privately insured patients (20%), and approximately $3.7 million USD for Medicaid patients (22%). Twenty-seven percent of patients (22% of all prescription fills) required additional FA with initial total co-payment claims of $335,216 USD. $280,988 USD of FA was obtained, which substantially lowered total patient costs by 81%. $250,818 USD of FA obtained was from foundation grants (327 fills), and $21,441 USD from manufacturer co-pay cards (47 fills). An additional $12,260 USD (12 fills) from a Karmanos Patient Assistance Fund was used. There was high dependence on foundation grant assistance among Medicare patients (33% of claims). In a subset analysis, the median time from prescription written to delivery to the patient was < 7 days (0-56 days). CONCLUSION: Twenty-seven percent of patients (22% of prescriptions fills) in 2019 required additional FA for high-cost drugs. KSP substantially reduced patient cost by implementing an efficient process using additional pharmacy assistants to obtain FA.
Prevalence of Enthesopathies in Adults With X-linked Hypophosphatemia: Analysis of Risk Factors
Authors: Herrou Julia , Picaud Axelle Salcion , Lassalle Louis , Pacot Laurence , Chaussain Catherine , Merzoug Valérie , Hervé Agathe , Gadion Margaux , Rothenbuhler Anya , Kamenický Peter , Roux Christian , Linglart Agnès , Duplan Martin Biosse , Briot Karine 
Published: August 2021

Abstract

Context
Enthesopathies are the determinant of a poor quality of life in adults with X-linked hypophosphatemia (XLH).

Objective
To describe the prevalence of patients with enthesopathies and to identify the risk factors of having enthesopathies.

Methods
Retrospective study in the French Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism between June 2011 and December 2020. Adult XLH patients with full body X-rays performed using the EOS® low-dose radiation system and clinical data collected from medical records.
The main outcome measures were demographics, PHEX mutation, conventional treatment, and dental disease with the presence of enthesopathies.

Results
Of the 114 patients included (68% women, mean age 42.2 ± 14.3 years), PHEX mutation was found in 105 patients (94.6%), 86 (77.5%) had been treated during childhood. Enthesopathies (spine and/or pelvis) were present in 67% of the patients (n = 76). Patients with enthesopathies were significantly older (P = .001) and more frequently reported dental disease collected from medical records (P = .03). There was no correlation between the PHEX mutations and the presence of enthesopathies. Sixty-two patients had a radiographic dental examination in a reference center. Severe dental disease (number of missing teeth, number of teeth endodontically treated, alveolar bone loss, and proportion of patients with 5 abscesses or more) was significantly higher in patients with enthesopathies.

Conclusion
Adult XLH patients have a high prevalence of enthesopathies in symptomatic adults patients with XLH seen in a reference center. Age and severe dental disease were significantly associated with the presence of enthesopathies.
Metal artifact reduction using common dental materials
Authors: Hinchy Nicole V , Anderson Nina K , Mahdian Mina 
Published: August 2021

ObjectivesTo determine the effect of different dental lab materials on cone beam computed tomography (CBCT) metal artifact at different resolutions.MethodsA total of seven common dental lab materials were molded to a dental sextant of four extracted, restored teeth. In addition to base alone (control), each material was scanned using the Carestream 9600 CBCT unit at three resolutions – 0.3 mm, 0.15 mm, and 0.075 mm – at manufacturer established exposure parameters. A single, representative axial view of each trial was evaluated for metal artifact both quantitatively by histogram analysis and qualitatively by profile plot analysis in ImageJ.ResultsNo statistically significant differences between the control and the dental materials were found; however, post-hoc tests showed significance between Blu-mousse®and polyvinyl siloxane with dental materials and control, predominantly in lower resolutions.ConclusionsThe current study provides initial evidence on the influence of dental materials have on CBCT metal artifact as described by beam hardening, photon starvation, scatter, and noise, especially at lower resolutions. Blu-Mousse®and polyvinyl siloxane reduced the perceived beam hardening and photon starvation artifact the greatest, relative to other materials, at all three resolutions and lower resolutions, respectively.