bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships Between Care Burden, Resilience, and Depressive Symptoms Among the Main Family Caregivers of Stroke Patients: a Cross-sectional Study
Authors: Fang Linlin , Dong Mengyuan , Zheng Jin 
Published: December 2021

Abstract
Background
Although studies indicate that resilience is related to care burden, and depressive symptoms, the underlying mechanism between those variables remains unknown. Thus, the present study aimed to explore the potential mediating role of resilience between care burden and depressive symptoms.
Methods
A cross-sectional study was conducted with a convenience sample of 245 main family caregivers of stroke patients recruited from the neurology department of Tertiary A hospital of China. The self-designed demographic characteristics for patients and caregivers、Barthel Daily Living Activities Index (BDLAI)、Zarit Caregiver Burden Interview (ZBI)、Connor-Davidson Resilience Scale (CD-RISC), and Center for Epidemiological Studies Depression Scale (CES-D) were used for investigation. Structural equation modeling (SEM) was conducted to explore the relationships between care burden, resilience, and depressive symptoms among the main family caregivers of stroke patients༎
Results
The average scores of care burden, resilience, and depressive symptoms for caregivers were 43.89 ± 13.40, 55.68 ± 11.01, and 22.33 ± 9.85, respectively. Pearson correlation analysis results showed that the care burden was positively related to depressive symptoms (r = 0.578, p < 0.01), resilience was significantly negatively related to both care burden (r = -0.264, p < 0.01) and depressive symptoms (r = -0.697, p < 0.01). Structural equation models (SEM) analysis indicated that resilience partially mediated the relationship between care burden and depressive symptoms with the mediation effect ratio of 23.8%.
Conclusions
Our study signifies that resilience plays a mediating role between care burden and depressive symptoms among the main family caregivers of stroke patients. This finding shows us that resilience can be a critical source to alleviate depressive symptoms.
Comparison of the efficacy of radiofrequency ablation vs. liver resection in the treatment of hepatocellular carcinoma within Milan criteria with severe fibrosis
Authors: Chen Lei , Xiang Dongqiao , Zhu Licheng , Wu Linxia , Ren Yanqiao , Sun Tao , Zhang Weihua , Sun Bo , Liu Yiming , Zheng Chuansheng 
Published: December 2021

Abstract
BackgroundThe efficacy of RFA in the treatment of HCC with severe fibrosis is still unclear. The objective of this study is to compare the efficacy of RFA with liver resection in the treatment of HCC within Milan criteria.MethodsThe data used in the study were from the SEER database. Patients with HCC within Milan criteria were included in the study. A total of 1432 patients were included in the study; among them, 1038 patients received RFA, and 394 patients received liver resection. Propensity score matching (PSM) was used to reduce selection bias.ResultsBefore PSM, the median overall survival (mOS) and median cancer-specific survival (mCSS) in the resection group were longer than the mOS and mCSS in the RFA group. However, the8re were no statistically significant differences in mOS or mCSS between the two groups (both P>0.05). After PSM, similar results were presented, and the mOS and mCSS in the resection group were similar to those in the RFA group (both P>0.05). The multivariable Cox regression analysis showed that RFA did not increase the all-cause mortality risk and cancer-specific mortality risk compared with resection before PSM. In the competing risk analysis, after excluding the potential factors that might influence the outcomes, RFA still did not increase the mortality risk compared with resection before PSM and after PSM. In the subgroup analysis. The efficacy of RFA is comparable to that of resection in patients with tumor sizes no more than 3 cm before PSM and after PSM.ConclusionThe efficacy of RFA is similar to that of resection in the treatment of early HCC patients with severe fibrosis, especially in patients with tumor sizes no more than 3 cm.
Prevalence of Uncoupled Sleep and Dysfunctional Sleep Beliefs in a Sample of Community-Dwelling Older Adults in Western Australia: A Cross-Sectional Study
Authors: Kutzer Yvonne , Whitehead Lisa , Quigley Eimear , Fu Shih Ching , Stanley Mandy 
Published: December 2021

Abstract
Objectives: Individuals who complain of insomnia may not always have objectively measured poor sleep, and vice versa, a phenomenon which is referred to as uncoupled sleepers. This study assessed the prevalence of uncoupled sleepers and levels of dysfunctional sleep beliefs in a sample of older adults in Western Australia.Method: 80 adults aged 60-80 years (71 females, 89%) completed a questionnaire, sleep diary and actigraphy measurements. Sleep related dysfunctional beliefs and self-rated sleep quality were assessed using the Dysfunctional Beliefs and Attitudes about Sleep scale (DBAS-16). Objective sleep quality was measured using an ActigraphTM model wGT3X-BT activity monitor and subjective sleep quality was assessed using a modified version of the Consensus Sleep Diary.Results: 52 of 80 participants (65%) were uncoupled sleepers. Individuals who complained of insomnia in the absence of objectively measured poor sleep showed worse self-reported sleep outcomes and higher dysfunctional beliefs, even though on actigraphy measurements there were no significant differences. Discussion: Future research should examine subjective and objective sleep parameters in older individuals. Interindividual differences in the relationship between perceived and measured sleep quality could present a target for potential therapeutic intervention.Trial Registration: Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN 12619001509156; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378451
Exploration of Dark Chemical Genomics Space via
Portal Learning: Applied to Targeting the
Undruggable Genome and COVID-19 Anti-Infective
Polypharmacology
Authors: Cai Tian , Xie Li , Chen Muge , Liu Yang , He Di , Zhang Shuo , Mura Cameron , Bourne Philip , Xie Lei 
Published: December 2021

Abstract
Advances in biomedicine are largely fueled by exploring uncharted territories of human
biology. Machine learning can both enable and accelerate discovery, but faces a fundamental
hurdle when applied to unseen data with distributions that differ from previously observed
ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework,
called Portal Learning, to explore dark chemical and biological space. Three key, novel components
of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s
sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model
selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) problem
in statistical machine learning. Here, we have implemented Portal Learning to predict chemicalprotein interactions on a genome-wide scale. Systematic studies demonstrate that Portal Learning
can effectively assign ligands to unexplored gene families (unknown functions), versus existing
state-of-the-art methods. Compared with AlphaFold2-based protein-ligand docking, Portal
Learning significantly improved the performance by 79% in PR-AUC and 27% in ROC-AUC,
respectively. The superior performance of Portal Learning allowed us to target previously
“undruggable” proteins and design novel polypharmacological agents for disrupting interactions
between SARS-CoV-2 and human proteins. Portal Learning is general-purpose and can be
further applied to other areas of scientific inquiry.
Identification of The Prognostic Genes For Early Basal-Like Breast Cancer With Weighted Gene Co-Expression Network Analysis
Authors: Yuan Keyu , Wu Min , Yu Xue , Zhao Xia , Feng Yu , Li Yanping , Lv Shuzhen 
Published: December 2021

Abstract
Background: Breast cancer (BC) has become the leading cause of death for women's malignancies and increasingly threatens the health of women worldwide. However, the basal-like BC is lack of effective targeted drugs. Therefore, biomarkers that related to the prognosis of early breast cancer need to be found.Methods: The RNA-seq data of 87 cases of early basal-like BC and 111 cases of normal breast tissue from The Cancer Genome Atlas (TCGA) were explored by Weighted Gene Co-Expression Network Analysis (WGCNA)method and Limma package. Then intersected genes (IGs) were identified and hub genes were selected by Maximal Clique Centrality method. The prognostic effect of the hub genes was also evaluated in early basal-like BC. Results: A total of 601 IGs were identified in this study. APPI network was constructed and top 10 hub genes were selected, namely cyclin B1 (CCNB1), cyclin A2 (CCNA2), cyclin dependent kinase 1 (CDK1), cell division cycle 20 (CDC20), DNA topoisomerase II alpha (TOP2A), BUB1 mitotic checkpoint serine/threonine kinase (BUB1), aurora kinase B (AURKB), cyclin B2 (CCNB2), kinesin family member 11 (KIF11), and assembly factor for spindle microtubules (ASPM). Only AURKB was found to be significant with the overall prognosis of early basal-like BC. The immune cells infiltration analysis displayed that the infiltration numbers of CD4+ T cell and naïve CD8+ T cell were positively correlated with AURKB expression level, while that of naïve B cell and macrophage M2 cell were negatively correlated with AURKB expression level in basal-like BC.Conclusion: AURKB might be a potential prognostic indicator in early basal-like BC.
Clinical Impact of 99mTc-MAA SPECT/CT-based Personalized Predictive Dosimetry in Selective Internal Radiotherapy: a Retrospective, Single-center Study for Unresectable HCC Patients
Authors: Bucalau Ana-Maria , Collette Benoît , Tancredi Illario , Vouche Michael , Pezzullo Martina , Bouziotis Jason , Moreno-Reyes Rodrigo , Trotta Nicola , Laethem Jean Luc Van , Verset Gontran 
Published: December 2021

Abstract
BackgroundRecent data indicates that personalized dosimetry-based selective internal radiotherapy (SIRT) may be associated with better outcome for unresectable hepatocellular carcinoma (HCC).AimWe aim to evaluate the contribution of personalized predictive dosimetry (performed with Simplicity90® software) in HCC patients by comparing them to our historical cohort whose activity was determined by standard dosimetry. MethodsThis is a retrospective, single-center study conducted between February 2016 and December 2020 that included patients with HCC who received SIRT after simulation based on either standard dosimetry (group A) or, as of December 2017, on personalized dosimetry (group B). Primary objectives were best overall response (BOR) and objective response rate (ORR) evaluated by mRECIST at 3 months. Safety and toxicity profiles were evaluated at day 1, 1- and 3-months post-treatment. For group A we studied the dose-response relationship at 3 months and compared the activity to be administered determined a posteriori using Simplicit90Y® and the activity actually administered determined by the standard approach.ResultsBetween February 2016 and December 2020, 66 patients received 69 simulations leading to 40 treatments. The median follow-up time was equal for both groups, 21 months (range 3-55) in group A and 21 months (range 4-39) in group B. The per patient analysis revealed a significant benefit of personalized predictive dosimetry in terms of better overall response at 3 months (80% vs. 33.3%, p= 0.007) and at 6 months (77.8% vs. 22.2%, p= 0.06). This trend was found in the analysis by nodule with a response rate according to mRECIST of 87.5% for personalized dosimetry versus 68.4% for standard dosimetry at 3 months, p= 0.24. Only one grade 3 biological toxicity (hyperbilirubinemia) was noted in group A. The comparison between the administered activity and the recommended activity recalculated a posteriori using Simplicit90Y® showed that the vast majority of patients who progressed (83.33%) received less activity than that recommended by the personalized approach or an inadequate distribution of the administered activity. ConclusionsOur study confirms that the use of personalized dosimetry allows a better selection of HCC patients who can benefit from SIRT, and consequently, improves the effectiveness of this treatment.
The Influence of Intrinsic Motivation on Decisions Between Actions
Authors: Cos Ignasi , Deco Gustavo , Gilson Matthieu 
Published: December 2021

Abstract
Extensive research explains how pre-frontal cortical areas process explicit rewards, and how pre-motor and motor cortices are recipients of that processing to energize motor behaviour. However, the specifics of motor behaviour, decisions between actions and brain dynamics when driven by no explicit reward, remain poorly understood. Are patterns of decision and motor control altered wen performing under social pressure? Are the same brain regions that typically process explicit rewards also involved in this expression of motivation? To answer these questions, we designed a novel task of decision-making between precision reaches and manipulated motivation by means of social pressure, defined by the presence or absence of virtual partner of a higher/lower aiming skill than our participants. We assessed the overall influence of this manipulation by analysing movements, decisions, pupil dilation and electro-encephalography. We show that the presence of a partner consistently increased aiming accuracy along with pupil diameter, furthermore the more skilled the partner. Remarkably, increased accuracy is attained by faster movements, consistently with a vigour effect that breaches speed-accuracy trade-offs typical of motor adaptation. This implicated an ensemble of cortical sources including pre-frontal areas, concerned with the processing of reward, but also pre-motor and occipital sources, consistent with the nature of the task. Overall, these results strongly suggest the role of social pressure as a motivational drive, enabling an increase of both vigour and accuracy in a non-trivial fashion.
Effect of Gender, Age and Vaccine on Reactogenicity and Incapacity to Work after COVID-19 Vaccination: A Survey among Health Care Workers
Authors: Nachtigall Irit , Bonsignore Marzia , Hohenstein Sven , Bollmann Andreas , Günther Rosita , Kodde Cathrin , Englisch Martin , Ahmad-Nejad Parviz , Schröder Alexander , Glenz Corinna , Kuhlen Ralf , Thürmann Petra , Meier-Hellmann Andreas 
Published: December 2021

Abstract
Background The aim of our study was to assess the influence of gender and age on reactogenicity by the different vaccines and their combinations. Further parameters were the reduction in working capacity after vaccination and the influence of the time of day when vaccines were administered. Methods We conducted a survey on COVID-19 vaccinations and eventual reactions among employees of 89 hospitals of the Helios Group. On May 19th, 2021 employees received an invitation by e-mail from the chief medical officer with a link to the survey tool. Participation was voluntary and non-traceable. The survey was closed on June 21st, 2021. Results 8,375 participants reported on 16,727 vaccinations. Reactogenicity was reported in 75% of COVID-19 vaccinations. In 23% the capacity to work was affected. Major risk factors were female gender, younger age and vaccine other than BNT162b2. ChAdOx induced impairing reactogenicity mainly after the prime vaccination (70.5%), while mRNA-1273 led to more pronounced reactions after the second dose (71.7%). Heterologous prime-booster vaccinations with ChAdOx followed by either mRNA-1273 or BNT162b2 were associated with the highest risk for impairment (81.4%). The time of day of the vaccinations showed no influence. Conclusions Young women had the highest chance to experience reactogenicity and to be unable to work after COVID-19 vaccination. When vaccinating a large part of a workforce, especially in professions with a higher proportion of women like health care, employers as well as employees must be prepared for a noticeable amount of absenteeism. Trial registration The study was approved by the Ethic Committee of the Aerztekammer Berlin on May 27th, 2021 (Eth-37/21) and registered in the German Clinical Trials Register (DRKS 00025745). The study was supported by the Helios research grant HCRI-ID 2021-0272.
Factors Determining Customer Satisfaction with Counter Services of Local Government Offices: On-Site Survey Examining Service Quality at Higashihiroshima City Hall, Japan
Authors: Moteki Yasutoshi 
Published: December 2021

Abstract
This study empirically investigated the major factors determining customer satisfaction with counter services in local government offices in Japan, comparing them with the results of similar surveys conducted by the author in 2020. This study considers visitors’ direct experience of counter services through an on-site survey conducted at a municipal government building, referring to (1) customer satisfaction research in various countries, especially the expectancy disconfirmation model; (2) the SERVQUAL model; and (3) subsequent methods that emphasise the customer’s direct experience. SERVQUAL, as the name suggests, is a five-group scale for evaluating service quality with respect to customer satisfaction. However, in actual organizational settings, five groups of questions may be burdensome to respondents and may reduce the collection rate. The author’s research involves conducting on-site surveys on customer satisfaction or service quality of the local government office using an original three-group questionnaire scale and tailoring the question items to a scale for Japanese local administration settings. The surveys comprise three categories of questions, referring to (1) customer satisfaction research in various countries, especially the expectancy disconfirmation model; (2) the SERVQUAL model; and (3) subsequent methods that emphasise the customer’s direct experience. A total of 1,000 questionnaires were distributed over four weekdays at the City Hall. As of September 27, 2021, there were 537 respondents (response rate: 53.7%). The regression analysis indicated that the independent variables of group C (service delivery) were most influential, followed by those of groups B (human-related factors) and A (office hardware) (adjusted R2 value: .58). Service delivery, human factors, and hardware aspects are important, in that order, to ensure customer satisfaction with the City Hall’s counter services. This is consistent with the results of the author’s Internet survey of users of Osaka City Government’s ward offices. Focusing on the second principal component of the service delivery category (C), promptness and short waiting times do not necessarily affect customer satisfaction positively.
Evaluation of An Online Tool About the Expected Course of Disease for Glioblastoma Patients – A Qualitative Study
Authors: Diest Eva van , Oldenmenger Wendy H , Eland Marit , Taal Walter 
Published: December 2021

Abstract
Background

Patients with glioblastoma have a short life-expectancy, with median survival rates of nine to twelve months. Providing information about the expected course of disease can be complicated. Therefore, an online tool has been developed. The objective of this tool is to better inform patients and proxies, and decrease their uncertainties and improve their quality of life. This study aims to gather experiences of future end-users, to identify if the tool meets the previously mentioned objectives.
Methods

This is a qualitative study based on thematic analysis. Interviews were conducted with fifteen patient-proxy dyads. For these interviews, a combined method of think-aloud sessions and semi-structured interviews was used. Audiotapes of these interviews were transcribed verbatim and thematically analyzed.
Results

The analysis revealed four major themes: unmet information needs, improvement possibilities, effects of the tool and clinical implementation. Participants indicated that this tool could decrease uncertainties and increase their perceived quality of life. Also, they often mentioned that it could have a positive effect on the efficiency and quality of consultations.
Conclusion

Participants considered this tool to be useful and effective in decreasing uncertainties and improving the quality of life for both patients with glioblastoma and their proxies. Moreover, participants brought up that this tool could positively influence the efficiency and quality of consultations. This could lead to more patient participation and empowerment, and could therefore enhance shared decision making and timely advanced care planning.
Inverted ILM flap technique in Optic Disc Pit Maculopathy: An Iranian experience with review of the literature
Authors: Tavallali Ali , Sadeghi Yasaman , Abtahi Seyed-Hossein , Nouri Hosein , Rezaei Mitra , Mazloumi Mehdi 
Published: December 2021

Abstract
Purpose

To present the outcome of optic disc pit maculopathy (ODPM) managed successfully with inverted internal limiting membrane (ILM) flap over the optic disc.
Methods

This prospective case series included three patients with ODPM who underwent pars plana vitrectomy with posterior vitreous detachment induction, followed by inverted ILM flap over the optic disc and gas tamponade. Patients were followed for 7-16 weeks as regards their functional and anatomical findings. A narrative review is also provided about Pathology, Pathogenesis, and surgical techniques in the treatment of ODPM
Results

Three adult patients (25–39 years old) were evaluated, with a mean duration of decreased visual acuity of 7.33 ± 2.40 months (4-12 months). Postoperatively, BCVA improved dramatically in one patient from 2/200 to 20/25. BCVA in the other two improved two and three lines, to 20/50 and 20/30, respectively. Significant anatomic improvement was achieved in all patients.
Conclusion

Vitrectomy with inverted ILM flap insertion over the optic disc can yield favorable anatomical improvement in patients with ODPM.
Cultural and contextual considerations in designing programs to support the incorporation of early childhood development within ongoing national nutrition programmes: A focus on the Baby-Friendly Community Initiative (BFCI) in a rural African context
Authors: Kitsao-Wekulo Patricia , Haycraft Emma , Mwoma Teresa , Okelo Kenneth , Kinuthia Esther , Muriuki Peter , Onyango Silas , Kimiywe Judith , Wanjohi Milka , Kimani-Murage Elizabeth , Griffiths Paula 
Published: December 2021

Abstract
The Baby Friendly Community Initiative (BFCI) offers a unique platform for integration of counselling on early childhood development (ECD) with existing maternal and child health and nutrition messages. To understand how to efficiently deliver such a program, this study determined the feasibility of integrating counselling on child stimulation into the Kenyan BFCI activities. Qualitative interviews (N=97) among female (aged 15-49 years) and male users, stakeholders, and services providers in Koibatek sub-County (mainly inhabited by the Tugen people, a Nilotic group in sub-Saharan Africa) provided extensive information on understanding regarding ECD, caregiving beliefs, needs at different levels and barriers and facilitators. Contextual influences and existing health system infrastructure are important considerations when designing integrated interventions to improve nurturing care of children.