bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving vegetable production under semi-arid, saline conditions in south-western Madagascar
Authors: Andriamparany Jessica N. , Hanisch Susan , Buerkert Andreas 
Published: January 2021

AbstractAgricultural production on the Mahafaly Plateau in SW-Madagascar has traditionally been based on subsistence rain-fed agriculture, with yields declining as a result of low soil fertility, recurrent droughts, and erratic rainfall. Market-oriented vegetable production in this area may help households improve their nutrition and diversify their income. In field trials between the 2013 and 2016 dry cropping seasons, the feasibility of carrot (Daucus carota L.) and onion (Allium cepa L.) production was assessed by testing effects of manure and charcoal amendments, shading, and seed quality on yields. Due to damage caused by cyclones and strong winds, only data from 2013 and 2016 are reported in this paper. Additionally to the field experiments, effects of salinity on seed germination were also examined under laboratory conditions and in the field. Carrot dry matter (DM) yields were 0.24 to 2.76 t·ha−1 while those of onion were 0.15 to 0.99 t·ha−1 DM. While the combination of manure and charcoal application had only minor effects on crop growth, manure alone increased carrot yield by 26% across years. After one cropping season, manure application reduced soil pH from 9.0 to 8.6 and increased soil Corg from 0.87 to 1.76%, N from 0.08 to 0.14%, and P from 10.6 to 15.1 mg·kg−1. Shading reduced carrot yields from 0.87 to 0.58 t·ha−1 DM in 2013 and from 1.87 to 0.85 t·ha−1 DM in 2016, but increased onion yield in 2013 from 0.24 to 0.62 t·ha−1 DM. Carrot seed procured locally performed better in the field than seed imported from the capital which translated into differences in seedling emergence. Saline irrigation water (electrical conductivity = 7.03 mS·cm−1) reduced seedling emergence rate of carrot from 73 to 20% and for onion from 44 to 28% and unprimed seeds performed better than primed ones. Using shading during the dry season is not advisable for carrot and onion production, but improving seed quality and targeted use of soil amendments (time of manure application, manure quality) may enhance vegetable yields.
Association of basic vaccination with cognitive and learning ability among children: insights from the India Human Development Survey, 2004–05 and 2011–12
Authors: Joe William , Kumar Verma Ajay 
Published: January 2021

AbstractBasic vaccination is important to protect children from infectious diseases and illnesses. Adequate levels of vaccination coverage reduce the morbidity and mortality burden among children and promote their physical and mental development. This study aimed to assess the association between basic childhood vaccination and the cognitive and learning ability of school children in India. Nationally representative follow-up data on 6183 children from the Indian Human Development Surveys conducted in 2004–05 and 2011–12 (IHDS I & II) were analysed. Children aged 8–10 years who had received all basic vaccines by the age 12 months performed better in a maths test than partially vaccinated or unvaccinated children (OR: 1.87, 95% CI: 1.48, 2.35). Similarly, fully vaccinated children performed better in writing tasks than partially vaccinated or unvaccinated children (OR: 1.77, 95% CI: 1.44, 2.18). Likewise, fully vaccinated children had better reading skills than fully unvaccinated children (OR: 1.60, 95% CI: 1.23, 2.09). The results suggest that enhancing child vaccination coverage can have significant benefits beyond health and can potentially improve the long-term educational outcomes of children.
A prospective study on the feasibility of cochlear implantation during the coronavirus disease 2019 crisis and trends of assessment: experience in a UK centre
Authors: Mohammed H , Kennedy L , Whitehead D , Ahmad N , Banerjee A 
Published: January 2021

AbstractObjectivesTo demonstrate the feasibility of continuing cochlear implantation during the coronavirus disease 2019 crisis and to report on trends of referrals via the neonatal hearing screening programme.MethodsA prospective case series was conducted on children who underwent cochlear implantation during the coronavirus disease 2019 crisis in the UK and a sample of referrals via the neonatal hearing screening programme. A step-by-step description of peri-operative management is included.ResultsRegionally, between February and May 2020, 106 babies were referred via the neonatal hearing screening programme to paediatric audiology. Eleven children were operated on during the coronavirus disease 2019 study period. None of the 11 children developed coronavirus symptoms.DiscussionIt is widely recognised that the demands of managing the current pandemic may compromise screening, clinical assessment and elective surgery. Time-sensitive issues such as cancer management have gained prominence, but a similar need exists for timely paediatric cochlear implantation.ConclusionImplantation in the paediatric population during the coronavirus disease 2019 pandemic is feasible with careful planning.
Factors associated with human visceral leishmaniasis cases during urban epidemics in Brazil: a systematic review
Authors: da Silva Santana Cruz Cleya , Soeiro Barbosa David , Oliveira Vinícius Cunha , Cardoso Diogo Tavares , Guimarães Nathália Sernizon , Carneiro Mariângela 
Published: January 2021

AbstractVisceral leishmaniasis (VL) is endemic in 70 countries and has been reported in 12 countries of Latin America, with over 90% of the cases reported in Brazil, where epidemics have occurred since 1980. The objective of this review is to describe the factors associated with the occurrence of VL epidemics in humans in urban areas. A systematic review was conducted according to the PRISMA-P guidelines. The databases PubMed (by Medline), Cochrane Library, Embase, Amed, LILACS and grey literature [Google Scholar and handsearch of the database of the Information System for Notifiable Diseases (SINAN) of Brazil's Unified Health System] were used. The protocol was registered under PROSPERO (CRD42019128998). Climatic, environmental factors and indicators of urban social structure were described as influencing the outbreaks in the North and Northeast regions. Gender and age characteristics were related to a greater chance of developing VL in the Central-West, Northeast and Southeast regions. Vector indicators showed a positive correlation with the incidence of VL in studies in the Northeast region. In the Southeast and Northeast regions, studies revealed the presence of dogs with positive correlation with VL. Knowledge gaps remain regarding the contribution to the increase in the risk factors described in ecological approaches, as no analysis was performed at the individual level, and it is still necessary to discuss the influence of other associated elements in epidemic episodes in the spread of VL.
Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance toAscarisinfection
Authors: Deslyper Gwendoline , Murphy Dearbhla M. , Sowemimo Oluyomi A. , Holland Celia V. , Doherty Derek G. 
Published: January 2021

AbstractThe soil-transmitted helminthAscaris lumbricoidesinfects ~800 million people worldwide. Some people are heavily infected, harbouring many worms, whereas others are only lightly infected. The mechanisms behind this difference are unknown. We used a mouse model of hepatic resistance toAscaris, with C57BL/6J mice as a model for heavy infection and CBA/Ca mice as a model for light infection. The mice were infected with the porcine ascarid,Ascaris suumor the human ascarid,A. lumbricoidesand immune cells in their livers and spleens were enumerated using flow cytometry. Compared to uninfected C57BL/6J mice, uninfected CBA/Ca mice had higher splenic CD4+andγδT cell counts and lower hepatic eosinophil, Kupffer cell and B cell counts. Infection withA. suumled to expansions of eosinophils, Kupffer cells, monocytes and dendritic cells in the livers of both mouse strains and depletions of hepatic natural killer (NK) cells in CBA/Ca mice only. Infection withA. lumbricoidesled to expansions of hepatic eosinophils, monocytes and dendritic cells and depletions of CD8+,αβ, NK and NK T cells in CBA/Ca mice, but not in C57BL/6J mice where only monocytes expanded. Thus, susceptibility and resistance toAscarisinfection are governed, in part, by the hepatic immune system.
Anxiety in asthma: a systematic review and meta-analysis
Authors: Ye Gang , Baldwin David S. , Hou Ruihua 
Published: January 2021

AbstractBackgroundBackground: Growing evidence from observational studies indicates a high prevalence of anxiety in asthma. However, prevalence rates of coexisting anxiety symptoms and comorbid anxiety disorders vary widely across studies. We aimed to evaluate the associations between anxiety and asthma and provide more precise comorbidity estimates.MethodsWe systematically reviewed the literature from case-controlled studies and conducted a meta-analysis to evaluate the pooled prevalence estimates and risks of anxiety symptoms and anxiety disorders in asthma individuals. Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic reviews and meta-analysis. A random-effects model was used to calculate pooled prevalence rates. Meta-analysis was conducted using Review Manager 5.3. Multiple databases including PubMed, ScienceDirect, PsychINFO, and PsycARTICLES were searched for publications before 1 December 2019. The review protocol was registered on PROSPERO (ref: CRD42020176028).ResultsIn total, 19 studies involving 106813 participants were included. The pooled prevalence of anxiety symptoms and anxiety disorders in individuals with asthma was 0.32 (95% CI 0.22–0.43) and 0.24 (95% CI 0.13–0.41), respectively. The risks of coexisting anxiety symptoms and comorbid anxiety disorders were significantly higher in asthma patients than in non-asthma controls indicated by OR 1.89 (95% CI 1.42–2.52; Z = 4.37; p < 0.001) and OR 2.08 (95% CI 1.70–2.56; Z = 6.97; p < 0.001), respectively. Anxiety symptoms and anxiety disorders occur at increased frequency among patients with asthma.ConclusionsOur findings highlight the need for appropriate assessments for these comorbid conditions, which may help to identify a subgroup of patients who might benefit from interventions designed to reduce anxiety and enhance the quality of life.
Social relationships and depression during the COVID-19 lockdown: longitudinal analysis of the COVID-19 Social Study
Authors: Sommerlad Andrew , Marston Louise , Huntley Jonathan , Livingston Gill , Lewis Gemma , Steptoe Andrew , Fancourt Daisy 
Published: January 2021

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) pandemic led to measures that reduced social contact and support. We explored whether UK residents with more frequent or supportive social contact had fewer depressive symptoms during March−August 2020, and potential factors moderating the relationship.MethodsA convenience sample of UK dwelling participants aged ⩾18 in the internet-based longitudinal COVID-19 Social Study completed up to 22 weekly questionnaires about face-to-face and phone/video social contact frequency, perceived social support, and depressive symptoms using the PHQ-9. Mixed linear models examined associations between social contact and support, and depressive symptoms. We examined for interaction by empathic concern, perspective taking and pre-COVID social contact frequency.ResultsIn 71 117 people with mean age 49 years (standard deviation 15), those with high perceived social support scored 1.836 (1.801–1.871) points lower on PHQ-9 than those with low support. Daily face-to-face or phone/video contact was associated with lower depressive symptoms (0.258 (95% confidence interval 0.225–0.290) and 0.117 (0.080–0.154), respectively) compared to no contact. The negative association between social relationships and depressive symptoms was stronger for those with high empathic concern, perspective taking and usual sociability.ConclusionsWe found during lockdown that those with higher quality or more face-to-face or phone/video contact had fewer depressive symptoms. Contact quality was more strongly associated than quantity. People who were usually more sociable or had higher empathy had more depressive symptoms during enforced reduced contact. The results have implications for COVID-19 and potential future pandemic management, and for understanding the relationship between social factors and mental health.
A pilot study on the effectiveness of low-intensity cognitive behavioural therapy (LiCBT) for common mental disorders in Hong Kong
Authors: Powell Candice L.Y.M. , Lo Alfred Pak-Kwan , Yeung Gladys T.Y. , Leung Natalie T.Y. , Mak Winnie W.S. , So Suzanne H.W. , Chiu Chui-De , Yau Sania S.W. , Mullan Eugene G. , Leung Patrick W.L. 
Published: January 2021

Abstract

Background:
To cope with the rising demand for psychological treatment, evidence-based low-intensity cognitive behavioural therapy (LiCBT) delivered by trained para-professionals was introduced internationally.

Aims:
This pilot study aimed at examining the effectiveness of LiCBT in Hong Kong.

Method:
This study was of an uncontrolled pre- and post-treatment design, testing LiCBT at a local community mental health centre in Hong Kong. Two hundred and eighty-five Chinese adult help-seekers to the centre attended two or more sessions of LiCBT delivered by trained para-professionals. These participants also rated their depression and anxiety on the Patient Health Questionnaire-9 (PHQ-9) and Generalised Anxiety Disorder Scale-7 (GAD-7), respectively, at pre- and post-treatment.

Results:
Comparison of the pre- and post-treatment PHQ-9 and GAD-7 scores of 285 participants indicated significant improvements in depression and anxiety with large effect sizes (depression: d = 0.87; anxiety: d = 0.95). For those participants reaching the clinical level of either depression and/or anxiety at pre-treatment (n = 229, 80.4%), they reported even larger effect sizes (depression: d = 1.00; anxiety: d = 1.15). The recovery rate was 55.9% with a reliable improvement rate of 63.9%. An average of 5.6 sessions was offered to the participants with each session spanning a mean of 42 minutes. The baseline clinical conditions and participants’ educational level were predictive of post-treatment recovery.

Conclusions:
The results supported the effectiveness and cost-efficiency of LiCBT for depression and anxiety at a Hong Kong community mental health centre. The effect sizes and the recovery and reliable improvement rates achieved were comparable to those reported from countries such as the UK and Australia.
Of Calendars—and Kings—and Why the Winter is Boiling Hot
Authors: HÄBERL CHARLES G. 
Published: January 2021

Abstract
This article documents the evolution and survival of an institution that has persisted nearly two and a half millennia until the present day. This institution, the Mandæan calendar, has evolved since its origins in the early Hellenistic period, and has been faithfully maintained since 472 ce at the latest. Its essential structure, 12 equal months of 30 days extended with the addition of five days to maintain its correspondence with the passage of the seasons, has evidently not changed since its initial adoption. After introducing the basic elements of time-keeping among Mandæans today, the article addresses the system of days, months, years, eras, and ages employed in the Mandæan scriptures, and correlates them with the present Mandæan calendar as well as the Julian and Gregorian calendars.
Diet quality improvement and 30-year population health and economic outcomes: a microsimulation study
Authors: Herman Patricia M , Nguyen PhuongGiang , Sturm Roland 
Published: January 2021

AbstractObjective:Diets closer aligned with nutritional guidelines could lower the risk of several chronic conditions and improve economic outcomes, such as employment and healthcare costs. However, little is known about the range, order of magnitude and timing of these potential effects.Design:We used a microsimulation approach to predict US population changes over 30 years in health and economic outcomes that could result from a substantial (but not impossible) improvement in diet quality – an improvement from the third to the fifth quintile of US scores on the Alternate Healthy Eating Index, 2010 version.Setting:Risk ratios from the literature for diabetes, heart disease and stroke were used to modify the Future Adult Model (FAM) to simulate outcomes from a higher-quality diet. Model parameter uncertainty was assessed using bootstrap and sensitivity analysis examined the variation in published risk ratios.Participants:FAM simulates outcomes for the US adult population aged 25 and older.Results:Improved diet quality initially leads to very small changes in chronic disease prevalence, but these accumulate over time. If diets improved beginning in 2019, after 30 years diabetes prevalence could be reduced by 5·9 million cases (11·5 %), heart disease prevalence by 4·0 million cases (7·2 %) and stroke prevalence by 1·9 million cases (10·3 %). These reductions in disease prevalence would be accompanied that same year by fewer deaths (88 000) and healthcare cost savings of $144·0 billion (2019 USD).Conclusions:This microsimulation study suggests that improvements in diet are likely to improve health and economic population outcomes over time.
CONFORMAL IMAGE REGISTRATION BASED ON CONSTRAINED OPTIMIZATION
Authors: MARSLAND S. , MCLACHLAN R. I. , TUFAIL M. Y. 
Published: January 2021

AbstractImage registration is the process of finding an alignment between two or more images so that their appearances match. It has been widely studied and applied to several fields, including medical imaging and biology, where it is related to morphometrics. In this paper, we present a construction of conformal diffeomorphisms which is based on constrained optimization. We consider a set of different penalty terms that aim to enforce conformality, based on discretizations of the Cauchy–Riemann equations and geometric principles, and demonstrate them experimentally on a variety of images.
DEBATING GENDER
Authors: Earp Brian D. 
Published: January 2021

AbstractThere is an ongoing public debate about sex, gender and identity that is often quite heated. This is an edited transcript of an informal lecture I recorded in 2019 to serve as a friendly guide to these complex issues. It represents my best attempt, not to score political points for any particular side, but to give an introductory map of the territory so that you can think for yourself, investigate further, and reach your own conclusions about such controversial questions as ‘What does mean to be a man or a woman?’
OUR SOUL MAKES US WHO WE ARE
Authors: Swinburne Richard 
Published: January 2021

ABSTRACTA ‘complex’ theory of personal identity analyses a person P2 being the same as an earlier person P1 in terms of some particular degree of physical or mental continuity between them. All such theories are open to an objection that the postulated degree of continuity is an arbitrary one, and many of them are open to the objection that more than one subsequent person could satisfy them. Necessarily, any subsequent person is either totally the same person as P1 or not at all the same as P1. P2 is identical with P1 if and only if P2 has the same (non-physical and indivisible) soul as P1.
CONSIDERING WHERE IS GOD IN A CORONAVIRUS WORLD? AN EXERCISE IN CRITICAL THINKING
Authors: Worley Peter 
Published: January 2021

ABSTRACTThis article is a critical response to a short book by John C. Lennox entitled Where is God in a Coronavirus World? in which he rejects atheism as a world-view equipped to deal with an event such as the coronavirus crisis and makes a case for the Christian outlook as the best way to meet such a crisis. The aim of this article is not to affirm or deny theism, but to examine critically the key arguments put forward for Christianity and against atheism by Lennox. Because of the centrality of the appeal to free will by Lennox in his article, some time is spent considering the free will response to the problem of evil, in which some close examination of the Bible is undertaken. The article finishes by outlining a personal, humanistic, secular response to the coronavirus crisis, and addresses solace and hope, two things Lennox denies atheism can provide.
Using diffusion of innovations theory to understand agricultural producer perspectives on cover cropping in the inland Pacific Northwest, USA
Authors: Lavoie Avery Lynn , Dentzman Katherine , Wardropper Chloe Bradley 
Published: January 2021

AbstractThere is increased interest in cover crops on farms; those planted during the fallow period or in place of a cash crop to improve soil and water quality. Despite extensive research suggesting that the practice can enhance on-farm resilience, cover crop use is not widespread, especially across the dryland wheat-growing region of the USA inland Pacific Northwest. Cover crops are being promoted across this region as a means to improve agronomic conditions and farmer livelihoods. Yet, there is limited producer-centered social science research to understand the regional and field-level challenges associated with the practice. To address this gap, we draw from the diffusion of innovations theory to examine the perceived relative advantage (the degree to which cover crops are compatible with the current agricultural system), and trialability of cover crops. Trialability encompasses the relative complexity and observability of the practice. Interviews (n = 28) were conducted with producers to better understand perceptions on relative advantage and how cover crop characteristics may contribute to barriers to adoption. Based on the results from interviews, focus groups (n = 48) were conducted to explore potential avenues for improving the integration of cover crops into existing cropping systems. Analysis of interviews with dryland crop and livestock producers suggested that perceptions of low relative advantage, including low compatibility with common regional management systems, perceived lack of profitability and increased cost of inputs act as deterrents to cover crop integration. Low trialability was associated with the complexity of experimentation, a lack of directly observable results and inflexible regional policies. These perceptions were compounded by a lack of region-specific agronomic and economic information on cover crops. Analysis of focus groups with crop and livestock producers and agricultural stakeholders suggested that there are several opportunities to improve potential adoption strategies and improve perceptions of relative advantage and trialability. Understanding the unique management goals of producers within the environmental, social and economic context in which they operate will better inform regional policies, outreach and future adoption strategies.
Targeting ubiquitin signaling for cancer immunotherapy
Authors: Zhou Xiaofei , Sun Shao-Cong 
Published: January 2021

AbstractCancer immunotherapy has become an attractive approach of cancer treatment with tremendous success in treating various advanced malignancies. The development and clinical application of immune checkpoint inhibitors represent one of the most extraordinary accomplishments in cancer immunotherapy. In addition, considerable progress is being made in understanding the mechanism of antitumor immunity and characterizing novel targets for developing additional therapeutic approaches. One active area of investigation is protein ubiquitination, a post-translational mechanism of protein modification that regulates the function of diverse immune cells in antitumor immunity. Accumulating studies suggest that E3 ubiquitin ligases and deubiquitinases form a family of potential targets to be exploited for enhancing antitumor immunity in cancer immunotherapy.