bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Inequity Survey to the Teachers of St. Aloysius Academy of Dasmariñas: A Basis for Digital Trust and Intuition
Authors: Avila Crisanto E. 
Published: April 2021

In the field of education, teachers must be technologically abreast especially in time of the COVID-19 Pandemic addressing the demand of the New Normal. To build confidence and capacity in digital teaching-learning, teachers must consider developing their skills in using digital technologies in education and they must also embed the use of digital devices in the teaching-learning practice. In this premise, this research article explains the digital inequality that the teachers are experiencing and its effect on their teaching profession and on establishing among themselves the digital trust and intuition. This study also aimed to answer, “What are the digital equalities do teachers encounter?” Th teachers’ decision for digital trust and intuition is affected by the digital inequalities they are experiencing. This study draws insights from a one-page survey questionnaire to 20 selected teachers of St. Aloysius Academy of Dasmariñas representing the faculty from the 3 departments such as preschool, grade school and high school. The results of this study indicate that teachers of St. Aloysius Academy of Dasmariñas are digitally inclined as manifested by their subscriptions to various digital devices and services. The impact of the digital technology to them in terms of social, economic, political and cultural affects their decision in digital trust and intuition. Overcoming issues on digital inequality among teachers will lead to digital trust and intuition. The school, from where the teachers are employed must address the digital inequality by ensuring that all teachers have equal chances in accessing the technology-based teaching devices and by providing them capacity building trainings which are imperative for the demand of the new normal. Teachers must embrace the digital technology in the community and in their workplace and imbibe the digital trust and intuition in education.
Communicative Sessions in Mixed-abilities Classroom: The Big Challenge for Low Achievers
Authors: Bellil Nedia 
Published: April 2021

Theoretically speaking, the communicative approach, and the communicative sessions based on it may seem to be suitable to all teaching contexts. However, in real classroom context, realities may be different especially in mixed abilities classes. This study is an attempt to bring awareness of the different kinds of difficulties low achievers face during the communicative sessions in mixed abilities classrooms. It tries to build links between the principles on which those sessions are built and the difficulties engendered by mixed-abilities classes. Data were collected by means of a questionnaire and an interview for both students and teachers of English, in addition to an observation of a number of communicative sessions in the Tunisian ELT context. The study revealed that the majority of low-level students are unable to cope with those sessions. They are highly demanding for them especially in a mixed-abilities context. They negatively affect low achievers’ self-esteem and motivation to learn English. The findings of the study can be used to enrich and support other researches dealing with similar issues. They can also help in deciding on the adequate solutions to low achievers’ problems with communicative activities in mixed-abilities learning context.
A Correlation Study of the Effectiveness of Teaching Practice between Taught Programs and Personal In-Built Performance Talents
Authors: Khidhir Rozhgar Jalal 
Published: April 2021

The study aims to identify the types of relationships related to the conversation, teaching methods, language testing, syntax, micro-teaching, classroom management, and teaching practice. It is hypothesized that there is no linear relationship between the two variables, r= 0. In other words, no connection is there between the teaching programs at the university and performing well at schools during practising. Thus, and by contrast, there is a linear relationship between the two variables, r ≠0. In other words, the teaching programs at the university and teaching practice are related. However, there is an uncertainty that performing well at schools could be solely due to the effectiveness of taught programs and personal in-built talents. Specifically, the study tries to answer these questions: 1. Is there any relationship between the teaching programs and teaching well at schools during practising? If yes, how strong is that? 2. Which teaching program is relatively strongly related to the teaching practice module? And 3. Does personal in-built talent bring about an escalation in performing well at schools during practicing? Also, the study aims to figure out any connection between programs at university and teaching performance at schools by identifying the type and the magnitude of the relationship available. Also, it attempts to highlight the most influential positive or negative connection between the taught program variables. Further, it reveals the rationale beyond teaching practice achievements and, consequently, relates them to the actual causes. The study revealed that there is a positive relationship between all the selected modules and teaching practice based on the Pearson Correlation test calculating the coefficient value output at 0.494 with a p. value of 0.000. Since correlation does not mean causation, the findings report a kind of confusion about whether teaching programs are beyond teaching well at schools.
Pattern of anti-diabetic treatment and its relation with glycaemic control among diabetic patients in a tertiary care hospital of Bangladesh
Authors: Akter Nazma 
Published: April 2021

Background: The main determinants of diabetes management, therapeutic habits and glycaemic control are likely to differ between populations. The pharmacological armamentarium to treat hyperglycaemia in type 2 diabetes mellitus (T2DM) has changed substantially over the past few years with the development of new therapeutic agents. This study evaluated relationships between pattern of pharmacological treatment and glycaemic control in patients with T2DM.
Methods: This cross-sectional study was carried out among 486 T2DM patients attending the endocrinology outpatient clinic of MARKS Medical College & Hospital, Dhaka, Bangladesh during the period between July 2018 and June 2019. After obtaining written informed consent, both the treatment pattern and the degree of glycaemic control were estimated from T2DM patients. Glycosylated hemoglobin A1C (HbA1c) was determined by liquid chromatography. Glycaermic control categorized as fair control (HbA1c <7.0%), poor control (HbA1c ³7.0%- <9.0%) and very poor control (HbA1c ³9.0%).
Results: Out of 486 participants, 65.8% were females. A total 68.1% of the patients were treated with oral antidiabetic drugs (OADs) and 31.9% were treated with both insulin and oral agents. Metformin (92.4%) was the most commonly used OAD; [p=0.01]. Over one fifth (22.1%) were taking combinations of sulfonylurea and metformin [p<0.05] and 19.5% were taking combination of sulfonylurea, metformin and dipeptidyl peptidase- IV inhibitors (DPP4i); [p=0.87]. More than one fourth (25.7%) were treated with two OADs along with insulin; [p=0.05]. In this context, familiar dual OADs combination (14.2%) was metformin and DPP4 inhibitors [p=0.86]. Premixed insulin (17.1%) was the frequently used regimen among different regimen of insulin used in both OADs and insulin group [p=0.22]. More than 50% of the subjects attained fair glycaemic target of HbA1c. But 46.3% accomplished poor and very poor glycaemic control [p=0.08].
Conclusion: The study shows that the proportion of patients treated with only oral diabetic agent was high. In most instances, they were treated with two or three drus combination therapies. The proportion of patients with fair glycaemic control was higher than reports from many countries.
Birdem Med J 2021; 11(2): 90-96
Spectrum of rheumatologic disorders among patients attending with musculoskeletal symptoms: experience from medicine outpatient department of a tertiary care hospital of Bangladesh
Authors: Haque Hasna Fahmima , Ahmed AKM Shaheen , Uddin Khwaja Nazim , Afroz Farhana , Afroze Samira Rahat , Hoque Md Tariful 
Published: April 2021

Background: Musculoskeletal conditions are prevalent and their impact is pervasive. They are one of the most common causes of long-term pain; affect hundreds of millions of people around the world; they significantly affect the psychosocial status of the affected people as well as their families and carers. This study was done to evaluate the spectrum of rheumatologic disorders among patients attending at medicine outpatient department (OPD) with musculoskeletal symptoms.
Methods: This cross-sectional study was done at OPD of Medicine, BIRDEM General Hospital from January 2014 to June 2017. All patients attending at OPD having musculoskeletal symptoms, who fulfilled criteria of definite rheumatologic disease and known rheumatologic disorders were consecutively and purposively included in this study.
Results: Total patients were 495 with female predominance (71.31%). Mean age was 48.6 years (range 18-76 years). Among the study population majority had inflammatory joint and spine diseases (69.69%);then degenerative joint and spine diseases (22.02%), connective tissue diseases (2.22).Two-thirds of the patients had rheumatoid arthritis (RA) (76.23%) among inflammatory joint and spine diseases, then ankylosing spondylitis (AS) (13.33%).Regarding connective tissue disease, systemic lupus erythematosus (SLE) was more frequent (45.5%). Among soft tissue rheumatism and metabolic bone disease, all study subjects had fibromyalgia (FM) and osteoporosis respectively. Rheumatoid factor was positive among two-thirds and anti-CCP antibody in twofifths of RA cases, HLA-B27 was positive in 4.3% of AS, antineuclear antibody (ANA) and anti-ds DNA were positive in all SLE patients. Common co-morbidities were diebetes (41.4%), ischaemic heart disease (20.6%) and hypertension (19.1%).
Conclusion: RA was the most common inflammatory joint disease. Degenerative diseases were the second most common condition. Common connective tissue disease was SLE.
Birdem Med J 2021; 11(2): 116-120
Fabry disease: a case report
Authors: Alam Afroja , Sharleen Nadia , Prianka Nusrat Jahan , Rahman Muhammad Raquib , Yesmin Mahbuba , Asaduzzaman ATM , Azad Md Abul Kalam 
Published: April 2021

Fabry disease is a rare X-linked recessive inborn error of metabolism due to deficient activity of the lysosomal enzyme, a-galactosidase A (a-Gal A). This results in the tissue accumulation of uncleaved glycosphingolipids within vascular endothelial lysosomes of various organs including skin, heart, kidneys and brain. We report a case of Fabry disease, in an 18-year-old boy, who presented with unilateral leg swelling and angiokeratoma corporis diffusum.
Birdem Med J 2021; 11(2): 145-147
PEMBUATAN KOLAM TERPAL UNTUK BUDI DAYA IKAN LELE DI PONDOK PESANTREN AT-THOHIRIYAH, TERPATIH GALAK SLAHUNG KABUPATEN PONOROGO
Authors: Satworo Adiwidodo  , Imam Mashudi  , Utsman Syah Amrullah  , R.N. Akhsanu Takwim  , Moh. Hartono  
Published: April 2021

Pondok Pesantren At Thoiriyah adalah pondok yang mengasuh kegiatan madrasah dinniyah dan tafidz Qur’an. Selain bekal agama yang mumpuni, pondok pesantren juga berusaha untuk membekali santri/santriwatinya dengan kemampuan untuk bisa mandiri di masyarakat dengan kemampuan pertanian, peternakan, pertukangan dan lain sebagainya. Santri/santriwati perlu dirangsang untuk belajar mandiri atau diajari melalui proses bimbingan untuk berperan aktif sebagai subyek pembangunan masyarakat. Sejalan dengan pemikiran di atas, diusulkan suatu kegiatan pemberdayaan masyarakat yaitu pelatihan dan pembuatan kolam terpal untuk budi daya ikan Lele di di Pondok Pesantren At-Thohiriyah, Terpatih Galak Slahung, Kabupaten Ponorogo. Kegiatan ini dirintis sebagai usaha untuk membangkitkan minat santri/santriwati untuk memulai usaha berdasarkan potensi usaha yang ada di lingkungan sekitar.
Hasil dari kegiatan ini adalah berupa 1 buah kolam terpal bulat dengan diameter 3 m dengan kedalaman 1 m dengan rangka wiremesh dengan alas terpal dan seperangkat modal awal untuk memulai usaha budidaya lele berupa benih dan pakan lele serta modul pelatihan.
PENINGKATAN KEWIRAUSAHAAN PADA ANGGOTA PKK RT 2 RW 9 DUSUN KLANDUNGAN DESA LANDUNGSARI KECAMATAN DAU KABUPATEN MALANG
Authors: Diana Eka  , Achmad Zaini  , Tri Wahyu Widodo  , Asminah Rachmi  
Published: April 2021

Pelaksanakan kegiatan sehari-hari, para anggota PKK di RT 2 RW 9 Dusun Klandungan Desa Landungsari Kecamatan Dau Kabupaten Malang masih banyak yang belum melakukan kegiatan yang produktif yang menghasilkan uang. Para anggota PKK belum melakukan kegiatan kewirausahaan secara berkelompok. Kalaupun ada beberapa anggota secara individu memiliki usaha sendiri berupa toko. Untuk membantu memperoleh pendapatan tambahan untuk rumah tangga para anggota PKK perlu melakukan kegiatan kewirausahaan yang produktif dan mudah dilakukan dirumah.
Beberapa masalah yang timbul di PKK RT2 RW 9 Dusun Klandungan Desa Landungsari berkaitan dengan kewirausahaan antara lain: tidak adanya bekal jiwa kewirausahaan, tidak adanya kemampuan/keterampilan kewirausahaan, tidak adanya pembina lapangan yang membimbing berwirausaha, tidak adanya modal untuk berwirausaha.
Pelatihan diperlukan untuk mengatasi permasalahan yang terjadi di PKK RT2 RW 9 Dusun Klandungan Desa Landungsari dalam kewirausahaan. Pelatihan yang perlu dilaksanakan tentang kewirausahaan meliputi : peningkatan motivasi berwirausaha, pemberian keterampilan kewirausahaan, pendampingan dengan kerjasama dengan pembimbing lapangan yang kompeten, bantuan modal/peralatan berwirausaha.
Politeknik Negeri Malang sebagai bagian dari masyarakat, yang merupakan lembaga pendidikan tinggi, dengan salah satu tugasnya adalah meningkatkan kualitas sumber daya manusia melalui jalur Pengabdian Masyarakat berkewajiban untuk memberikan bantuan pembimbingan kepada para anggota PKK di RT 2 RW 9 Dusun Klandungan Desa Landungsari Kecamatan Dau Kabupaten Malang
ABCA1 69C>T Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Systematic Review and Updated Meta-Analysis
Authors: Yoon Ha Young , Lee Min Hye , Song Yubin , Yee Jeong , Song Gonjin , Gwak Hye Sun 
Published: April 2021

BackgroundThe ATP-binding cassette transporter A1 (ABCA1) is likely associated with the risk of type 2 diabetes mellitus (T2DM) via β cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the ABCA1 69C&gt;T polymorphism and the risk of T2DM through a systematic review and meta-analysis.Materials and MethodsThe PubMed, Web of Science, and Embase databases were searched for qualified studies published until August 2020. Studies that included the association between the ABCA1 69C&gt;T polymorphism and the risk of T2DM were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated.ResultsWe analyzed data from a total of 10 studies involving 17,742 patients. We found that the CC or CT genotype was associated with increased risk of T2DM than the TT genotype (OR, 1.41; 95% CI, 1.02-1.93). In the Asian population, the C allele carriers had a higher risk of T2DM than those with the TT genotype; the ORs of the CC and CT genotypes were 1.80 (95% CI, 1.21-2.68) and 1.61 (95% CI, and 1.29-2.01), respectively.ConclusionsThis meta-analysis confirmed that the ABCA1 69C&gt;T genotype showed a decrease risk of T2DM compared to the CC or CT genotypes.
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia
Authors: Guan Yunpeng , Hou Xiaoyu , Tian Peipei , Ren Luping , Tang Yong , Song An , Zhao Jiajun , Gao Ling , Song Guangyao 
Published: April 2021

BackgroundTo investigate possible mechanisms of postprandial hypertriglyceridemia (PPT), we analyzed serum lipid and apolipoprotein (Apo) AI, B, CII and CIII levels before and after a high-fat meal.MethodsThe study has been registered with the China Clinical Trial Registry (registration number:ChiCTR1800019514; URL: http://www.chictr.org.cn/index.aspx). We recruited 143 volunteers with normal fasting triglyceride (TG) levels. All subjects consumed a high-fat test meal. Venous blood samples were obtained during fasting and at 2, 4, and 6 hours after the high-fat meal. PPT was defined as TG ≥2.5 mmol/L any time after the meal. Subjects were divided into two groups according to the high-fat meal test results: postprandial normal triglyceride (PNT) and PPT. We compared the fasting and postprandial lipid and ApoAI, ApoB, ApoCII and ApoCIII levels between the two groups.ResultsSignificant differences were found between the groups in fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), TG-rich lipoprotein remnants (TRLRs), ApoB, ApoCIII, ApoAI/ApoB and ApoCII/ApoCIII. The insulin, HOMA-IR, TG, TC, LDL-C, non-HDL-C, TRLRs, ApoB, ApoCIII and ApoCII/ApoCIII values were higher in the PPT group, while the ApoAI/ApoB ratio was higher in the PNT group. The postprandial TG level peaked in the PNT group 2 hours after the meal but was significantly higher in the PPT group and peaked at 4 hours. TRLRs gradually increased within 6 hours after the high-fat meal in both groups. The area under the curve (AUC) of TG and TRLRs and the AUC increment were higher in the PPT group (P &lt; 0.001). ApoCIII peaked in the PNT group 2 hours after the meal and gradually decreased. ApoCIII gradually increased in the PPT group within 6 hours after the meal, exhibiting a greater AUC increment (P &lt; 0.001). Fasting ApoCIII was positively correlated with age, systolic and diastolic blood pressure, body mass index (BMI), waist circumference, TC, TG, LDL-C, non-HDL-C, TRLRs, and ApoB (P&lt;0.05). ApoCIII was an independent risk factor of PPT after adjustment for BMI, waist circumference, TC, LDL-C, and ApoB (P &lt; 0.001, OR=1.188).ConclusionsElevated ApoCIII levels may cause PPT.
Sleep Quality Detection Based on EEG Signals Using Transfer Support Vector Machine Algorithm
Authors: Wen Wu 
Published: April 2021

BackgroundIn recent years, with the acceleration of life rhythm and increased pressure, the problem of sleep disorders has become more and more serious. It affects people’s quality of life and reduces work efficiency, so the monitoring and evaluation of sleep quality is of great significance. Sleep staging has an important reference value in sleep quality assessment. This article starts with the study of sleep staging to detect and analyze sleep quality. For the purpose of sleep quality detection, this article proposes a sleep quality detection method based on electroencephalography (EEG) signals.Materials and MethodsThis method first preprocesses the EEG signals and then uses the discrete wavelet transform (DWT) for feature extraction. Finally, the transfer support vector machine (TSVM) algorithm is used to classify the feature data.ResultsThe proposed algorithm was tested using 60 pieces of data from the National Sleep Research Resource Library of the United States, and sleep quality was evaluated using three indicators: sensitivity, specificity, and accuracy. Experimental results show that the classification performance of the TSVM classifier is significantly higher than those of other comparison algorithms. This further validated the effectiveness of the proposed sleep quality detection method.
Targeting Bruton Tyrosine Kinase With Zanubrutinib for Treatment of Vitreoretinal Lymphoma: Report of 3 Cases
Authors: Wang Liang , Guan Wenxue , Peng Xiaoyan 
Published: April 2021

Vitreoretinal lymphoma (VRL) is a rare intraocular malignancy, and standard treatment approaches have not been defined yet. Bruton tyrosine kinase inhibitors are found to be effective in the treatment of primary central nervous system diffuse large B cell lymphoma. Herein, we retrospectively reported the efficacy and safety profiles of bruton tyrosine kinase inhibitors in three consecutive patients with VRL. All three cases of VRL occurred in patients with pre-treated primary central nervous system lymphoma and the central nervous system was not involved at the time of VRL diagnosis. They were treated with zanubrutinib, a bruton tyrosine kinase inhibitor, at 160 mg twice daily orally. Rapid improvement of visual acuity and tumor control was achieved in all involved eyes of these 3 patients. Complete remission was confirmed by fundus photograph and optical coherence tomography, and the level of interleukin-10, a well-recognized biomarker for vitreoretinal lymphoma, decreased to normal in all patients. Zanubrutinib was well tolerated in all three patients, and only one adverse event of grade 3 hypertension occurred, which resolved after adjusting antihypertensive drugs. As of March 2021, these three patients have been treated with zanubrutinib for 9 months, 7 months, and 6 months, respectively, and all remained in complete remission. In conclusion, targeting bruton tyrosine kinase with zanubrutinib in vitreoretinal lymphoma is feasible and our findings can be a foundation for a paradigm shift in treatment options for this rare disease. A prospective phase 2 study evaluating the efficacy and safety of zanubrutinib in patients with vitreoretinal lymphoma is ongoing to validate our findings (ChiCTR2000037921).
Where Are the Newly Diagnosed HIV Positives in Kenya? Time to Consider Geo-Spatially Guided Targeting at a Finer Scale to Reach the “First 90”
Authors: Waruru Anthony , Wamicwe Joyce , Mwangi Jonathan , Achia Thomas N. O. , Zielinski-Gutierrez Emily , Ng'ang'a Lucy , Miruka Fredrick , Yegon Peter , Kimanga Davies , Tobias James L. , Young Peter W. , De Cock Kevin M. , Tylleskär Thorkild 
Published: April 2021

Background: The UNAIDS 90-90-90 Fast-Track targets provide a framework for assessing coverage of HIV testing services (HTS) and awareness of HIV status – the “first 90.” In Kenya, the bulk of HIV testing targets are aligned to the five highest HIV-burden counties. However, we do not know if most of the new HIV diagnoses are in these five highest-burden counties or elsewhere.Methods: We analyzed facility-level HTS data in Kenya from 1 October 2015 to 30 September 2016 to assess the spatial distribution of newly diagnosed HIV-positives. We used the Moran's Index (Moran's I) to assess global and local spatial auto-correlation of newly diagnosed HIV-positive tests and Kulldorff spatial scan statistics to detect hotspots of newly diagnosed HIV-positive tests. For aggregated data, we used Kruskal-Wallis equality-of-populations non-parametric rank test to compare absolute numbers across classes.Results: Out of 4,021 HTS sites, 3,969 (98.7%) had geocodes available. Most facilities (3,034, 76.4%), were not spatially autocorrelated for the number of newly diagnosed HIV-positives. For the rest, clustering occurred as follows; 438 (11.0%) were HH, 66 (1.7%) HL, 275 (6.9%) LH, and 156 (3.9%) LL. Of the HH sites, 301 (68.7%) were in high HIV-burden counties. Over half of 123 clusters with a significantly high number of newly diagnosed HIV-infected persons, 73(59.3%) were not in the five highest HIV-burden counties. Clusters with a high number of newly diagnosed persons had twice the number of positives per 1,000,000 tests than clusters with lower numbers (29,856 vs. 14,172).Conclusions: Although high HIV-burden counties contain clusters of sites with a high number of newly diagnosed HIV-infected persons, we detected many such clusters in low-burden counties as well. To expand HTS where most needed and reach the “first 90” targets, geospatial analyses and mapping make it easier to identify and describe localized epidemic patterns in a spatially dispersed epidemic like Kenya's, and consequently, reorient and prioritize HTS strategies.