bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of obstructive sleep apnea and high-sensitivity C-reactive protein on clinical outcome in off-pump coronary artery bypass grafting
Authors: Gao Mingxin , Fan Kangjun , Yu Wenyuan , Liu Hongli , Wei Yongxiang , Yu Yang 
Published: February 2021

Abstract
Purpose
This study aimed to investigate the relationship between obstructive sleep apnea (OSA) and high-sensitivity C-reactive protein (hs-CRP) to determine their effects on postoperative complications and clinical outcomes during hospitalization in patients undergoing off-pump cardiac artery bypass grafting (OPCABG).
Methods
This prospective, single-center study enrolled patients who underwent OPCABG. OSA was evaluated using a portable sleep monitor before OPCABG. Spearman correlation was performed to investigate the relationship between hs-CRP and polygraphy test indicators; regression analysis was performed to determine whether hs-CRP is an independent influencing factor for postoperative atrial fibrillation, duration of hospitalization, and hospital cost.
Results
Partial pressure of carbon dioxide (P = 0.033), high-sensitivity C-reactive protein (hs-CRP) (P = 0.001), apnea hypopnea index (AHI) (P = 0.000), mean apnea time (P = 0.000), maximum apnea time (P = 0.000), and ODI ≥ 3% (P = 0.000) were significantly higher in the moderate–severe OSA group than in the absent–mild OSA group. LVEF (P = 0.034), lowest arterial oxygen saturation (SaO2) (P = 0.000), and mean SaO2 (P = 0.000) were significantly lower in the moderate–severe OSA group. Hs-CRP levels correlated with AHI (rs = 0.235, P = 0.009), ODI ≥ 3% (rs = 0.228, P = 0.011), lowest SaO2 (rs = 0.186, P = 0.040), and mean SaO2 (rs = 0.331, P = 0.000). AHI independently correlated with hs-CRP levels (P = 0.01); hs-CRP was an independent risk factor for post-CABG atrial fibrillation (POAF) (OR = 1.17, P = 0.006); and hs-CRP level independently correlated with duration of hospitalization (P = 0.002) and hospital cost (P = 0.040).
Conclusion
Hs-CRP levels are closely related to the degree of OSA and have potential utility in predicting POAF, duration of hospitalization, and hospital costs in patients undergoing OPCABG.
A treatment planning system with new paradigms in the effectiveness and side-effect evaluation sections
Authors: Frometa-Castillo Terman , Pyakuryal Anil , Narayanasamy Ganesh , Mesbahi Asghar 
Published: February 2021

Abstract
Aim

Academic dissemination of the “SMp treatment planning system (TPS)” for external beam radiotherapy, which has been developed as a software function that could meet the definition of a device with an entirely new intended use. This system will have new paradigms in the effectiveness and side-effect (S-E) evaluation sections, where tumor control probability (TCP) is calculated with computational simulations instead of current analytical TCP models; and S-E is evaluated with the normal tissue non-complication probability (NTCP0) methodology instead of standard NTCP one.
Methods

Use of probabilistic foundations in the NTCP0 methodologies; and computational simulations of the interactions of ionizing radiation with the tumor tissues in the radiation oncology treatments for the TCP calculations.
Results

The "TCPsim" and “NTCP0cal” calculation modules of the SMp TPS, which calculate respectively TCP and NTCP0.
Conclusions

While the "NTCP0cal" application has unquestionable probabilistic foundations associated to normal tissue complications as a stochastic process with more than one outcome; the "TCPsim" is based on proper approaches that are result of the computational simulations that follow logic-probabilistic procedures, and probabilistic aspects, like the relationship between TCP and linear-quadratic cell survival model for a fraction with dose d.
Prediction and Assessment of Back Break by Multivariate Regression Analysis, and Random Forest algorithm in hot strata/fiery seam of open-pit coal mine
Authors: Sharma Mukul , Choudhary Bhanwar Singh , Agrawal Hemant 
Published: February 2021

Abstract
Coal seam in mines sometimes catches fire due to its property of spontaneous heating. Drilling and blasting techniques are the most economical operation for the removal of overburden and extraction of coal in an open-pit coal mine. Blasting in a fiery seam is one the most dangerous and risky operations and various environmental and technical problems are associated with it. While blasting in a fiery coal seam, it is essential to use the minimum amount of explosive in a hole and the blast should be taken quickly. As the amount of explosive to be used must be comparatively lesser; therefore, it becomes important to perform the blasting in a manner to maximize the utilization of explosive energy. Improper utilization of energy causes back break, which is one of the technical concerns for management due to the in-stability of high wall. This study is a unique attempt to predict back break, especially in fiery coal seam through the experimental blasts and their analysis by Multivariate Regression Analysis (MVRA), and Random Forest algorithm (RFA). Total 26 blasting were conducted at open pit mine. To obtain the most optimum blast design parameter, blast design parameters were varied. The observed back break during trial blasts varies from 1.4 to 10 m. The Sensitivity analysis performed with the collected data and it has been found that stiffness ratio and stemming length are the most influential parameters on generation of back break. The MVRA and RFA analysis have been adopted for accurate prediction of back break. The results show that the RFA analysis predicts the backbreak and achieved the RMSE of ± 0.59 m while in MVRA, RMSE achieved was ± 0.99 m, making RFA more suitable method to be used for backbreak prediction in fiery seam blasting.
Rho(D) Immune Globulin (anti-D) Concentration-Time Curve After Antenatal Immunoprophylaxis in RhD-Negative Pregnant Women
Authors: Silva Ana Cláudia Rabelo e , Santos Flávia Leite Souza , Quintana Silvana Maria , Cavalli Ricardo Carvalho , Marcolin Alessandra Cristina , Duarte Geraldo 
Published: February 2021

Abstract
Objectives: To assess anti-D concentration through maternal indirect antiglobulin test (IAT) titers and scores after RhD-negative pregnant women receive antenatal anti-D until delivery. Methods: Cross-sectional study. Twenty-seven RhD-negative pregnant women were evaluated after receiving a prenatal anti-D dose around 28th week of pregnancy. Serial blood samples were collected at 3, 7, 21, 42, 63 and 84 days after anti-D administration. We performed IAT by conventional tube test (CTT) and gel microcolumn assay (GMA) to assess anti-D scores and titers. Statistical analyzes were performed using IBM SPSS Statistics software. Results: Anti-D had maximum scores values ​around 7 days after its administration, and scores were higher in GMA than CTT for all patients. Anti-D was detected at delivery in 59% of the participants by IAT performed in GMA. Overweight and obese pregnant women may present lower concentrations of anti-D. No correlation was found between maximum scores when comparing them with these variables: newborn RhD blood type; maternal-fetal ABO incompatibility and the number of pregnancies. Conclusions: Administering 300 μg of anti-D in 28th week of pregnancy should be compared in studies analyzing perinatal outcomes, since anti-D was not detectable in 41% of patients, suggesting a significant period without prophylaxis.
First report of northern root-knot nematode, Meloidogyne hapla (Chitwood, 1949) on strawberry in Turkey
Authors: Özarslandan Adem , Dinçer Dilek , Yavuz Şefika , Aslan Ayşenur 
Published: February 2021

Abstract
Strawberry is one of the most economically important crops worldwide. Several species of plant-parasitic nematodes have been reported to be pathogenic on strawberries, among them the northern root-knot nematode (Meloidogyne hapla), which considered to be strawberry most important nematode pest worldwide. In August 2019, strawberry growers at Silifke (Mersin, Turkey) identified nematode-like symptoms on strawberry roots and infected seedlings were brought to the nematology laboratory at of Mersin University for diagnostics. Roots were separated into small pieces and nematode extraction was performed by a modified Baermann funnel method and identified under the microscope. DNA was extracted from individual nematodes using Worm Lysis Buffer(WLB (+)). The species-specific SCAR markers (JMV1, JMV2, and JMVhapla) yielded a 440 bp band specific to M. hapla. The 28S rRNA gene region, obtained using the general primers D2\D3, sequence was analysed from. The analyzed sequence was 100% identicle to M. hapla. The gene sequences were deposited into GenBank database with accession numbers MN897751 and MN895037. Both morphological and molecular diagnostic methods confirmed that the strawberry plants collected in Silifke were infested with M. hapla. To our best knowledge this is the first report of plant-parasitic nematode species M. hapla infecting strawberry in Turkey. Currently, the adverse effect of RKN on strawberry production in the region is unknown to strawberry growers.
The grazing activity of Acrobeloides sp. drives phytate mineralisation within its trophic relationship with bacteria
Authors: García-Sánchez Mercedes , Souche Mathilde , Trives-Segura Carlos , Plassard Claude 
Published: February 2021

Abstract
The microbial loop has been suggested as an alternative route for better utilization of phytate, a poorly available P source to plants. We hypothesized that bacterial grazer activity might dramatically enhance bacterial migration and proliferation, increasing the probability of phytate hydrolysis by bacterial phytases and, thus, phytate mineralization and release of free phosphate. We tested this hypothesis in a two-compartment system with a solid medium containing phytate or free phosphate as the source of P. Two bacterial species, B. subtilis 168 or Bradyrhizobium sp., with or without bacterial grazing nematodes belonging to Acrobeloides sp. previously fed on each of the bacterial species, were inoculated at a single point in the medium. Whatever the P source, nematode migration within both zones allowed the proliferation of bacteria. However, B. subtilis 168 was more efficient in using phytate than Bradyrhizobium sp. since the highest bacterial cell density and free phosphate concentrations were reached by Acrobeloides sp. fed on B. subtilis 168. The grazer activity seemed to be crucial to enhance phytate mineralization, despite Acrobeloides sp. showing a higher preference to feed on Bradyrhizobium sp. This study provides new insights into the effects of bacterial grazer activity on phytate mineralization.
On the formation of arrays of micro-tunnels in pyrope and almandine garnets
Authors: Rabier Jacques , Heuer Arthur H. , Hemker Kevin J. 
Published: February 2021

Abstract
A recent paper devoted to unusual fine-scale tubular tunnels found in pyrope and almandine garnets suggested that the 5 to 100 μm diameter tunnels were produced by an endolithic organism that is able to chemically dissolve and penetrate the mineral, perhaps in search of nutrients. The hypothesized microbial boring of the garnets was based on the finding of endolithic remains in the tunnels, but boring alone does not adequately explain the linear, highly aligned or occasionally branched tunnels that have been imaged. We have prepared this short Letter, in the spirit of Occam’s Razor, to highlight the very probable role that dislocations play in the creation of such tunnels by preferential etching of a dislocation-rich deformation microstructure. The geometrical features of the tunnels possess all the characteristics of classical dislocation substructures that have been observed in natural and synthetic garnets.
Adsorption of pyridine from aqueous solutions onto polyaluminium chloride and anionic polyacrylamide water treatment residuals
Authors: Duan Runbin , Fedler Clifford B. , Jiao Xiaofei 
Published: February 2021

Abstract
The adsorption performance of pyridine onto polyaluminium chloride (PAC) and anionic polyacrylamide (APAM) water treatment residuals (WTRs) was investigated by batch experiments. This study confirmed the assumption that PAC–APAM WTRs had the ability to remove pyridine. The non-linear Dubinin–Radushkevich model and non-linear Freundlich model better described the isotherms, indicating that the adsorption was a chemically controlled multilayer process. The pyridine adsorption rate was simultaneously controlled by external film diffusion and intraparticle diffusion. The adsorption of pyridine was an endothermic reaction with randomness increase. The pyridine adsorption decreased with pH increase. Pyridine removal was observed to be a linear increase from 6.16% to 96.18%, with the increase of dosage from 2.5 g/L to 15 g/L. The Langmuir maximum adsorption capacity was 3.605 mg/g while the theoretical isotherm saturation capacity was 9.823 mg/g. Therefore, PAC–APAM WTRs recycled into contaminated soils for remediation is expected to be an innovative alternative disposal method. More research is recommended in the future to identify detailed adsorption mechanisms and the most appropriate mixing ratio of PAC–APAM WTRs to contaminated soils under various climatic conditions.
RODA DE CONVERSA ENSINO REMOTO DE PROJETO DE AU EM CONTEXTO DE DISTANCIAMENTO SOCIAL - APRESENTAÇÃO
Authors: Veloso Maísa 
Published: February 2021

Apresenta os temas tratados e os palestrantes da Roda de Conversa sobre Ensino Remoto de Projeto realizada pelo Grupo PROJETAR/UFRN,
com a mediação da autora/apresentadora.
The Role of Hypoxia in Endometrial Cancer
Authors: Salinas-Vera Yarely M. , Gallardo-Rincón Dolores , Ruíz-García Erika , Silva-Cázares Macrina B. , de la Peña-Cruz Carmen Sol , López-Camarillo César 
Published: February 2021

Abstract:
Endometrial cancer represents the most frequent neoplasia from the corpus uteri, and comprises the 14th leading cause of death in women worldwide. Risk factors that contribute to the disease include early menarche, late menopause, nulliparity, and menopausal hormone use, as well as hypertension and obesity comorbidities. The clinical effectiveness of chemotherapy is variable, suggesting that novel molecular targeted therapies against specific cellular processes associated with the maintenance of cancer cell survival and therapy resistance urged to ameliorate the rates of success in endometrial cancer treatment. In the course of tumor growth, cancer cells must adapt to decreased oxygen availability in the microenvironment by upregulation of hypoxia-inducible factors, which orchestrate the activation of a transcriptional program leading to cell survival. During this adaptative process, the hypoxic cancer cells may acquire invasive and metastatic properties as well as increased cell proliferation and resistance to chemotherapy, enhanced angiogenesis, vasculogenic mimicry, and maintenance of cancer cell stemness, which contribute to more aggressive cancer phenotypes. Several studies have shown that hypoxia-inducible factor 1 alpha (HIF-1α) protein is aberrantly overexpressed in many solid tumors from breast, prostate, ovarian, bladder, colon, brain, and pancreas. Thus, it has been considered an important therapeutic target. Here, we reviewed the current knowledge of the relevant roles of cellular hypoxia mechanisms and HIF-1α functions in diverse processes associated with endometrial cancer progression. In addition, we also summarize the role of microRNAs in the posttranscriptional regulation of protein-encoding genes involved in the hypoxia response in endometrial cancer. Finally, we pointed out the need for urgent targeted therapies to impair the cellular processes activated by hypoxia in the tumor microenvironment.
Recent Advances in Chemistry and Biological Activity of 2,6-Diphenyl
Piperidines
Authors: Yousif Mahmoud N. M. 
Published: February 2021

:
The review discusses different methods for preparation of 2,6-diphenyl-piperidin-4-one derivatives. 2,6-Diphenyl-piperidin-4-one is prepared from aromatic aldehyde and acetone in ammonium acetate. Reaction of 1-phenylsulfinylpropan-2-one or 1-(4-chlorophenylsulfinyl)propan-2-one, aromatic aldehyde and ammonium acetate gives a series of 2,6-diaryl-2,3-dihydro-1H-pyridin-4-one 6a,b. 4-Phenyl-2-amino-1,3-butadienes reacts with N-allyl benzaldimine through Diels-Alder reaction to afford 2,6-diphenyl-4-piperidinone derivative 7. Also, reactions of 2,6-diphenyl-piperdin-4-one are discussed. The reactions of latter compounds can be on nitrogen atom or carbonyl function group or methylene group adjacent to carbonyl group. In addition, different applications of 2,6-diphenyl-piperidin-4-one are summarized.
Liposomes as Herbal Compound Carriers: An Updated Review
Authors: Jahadi Mahshid , Keighobadi Kourosh , Azimzadeh Behnaz , Keivani Hadiseh , Khosravi-Darani Kianoush 
Published: February 2021

Background and Objective:
Beneficial effects of phytochemicals on human health have
recently been investigated by researchers. In this review, after a short description of the beneficial
health effects of the herbal compounds, the obstacles of their use in pharmaceutical and
nutraceutical fields have been discussed. Encapsulation technique has been studied as a solution to
overcome the limitations, and finally, liposomes have been introduced as the carriers.

Methods:
Online articles were searched through various databases, including PubMed, Web of
Science, Google Scholar, and Scopus, 2003-2020, to find reviews, editorials, and articles on the
effects of herbal compounds on human health. Furthermore, increasing the stability of the phytocompounds
by using encapsulation in liposomes produced by heating methods is included in the
methodology.

Results:
Herbal-derived compounds seem to be potential tools for the prevention of disorders.
However, they are susceptible to environmental stress. Encapsulation of herbal-derived compounds
in liposomes and nanoliposomes is suggested to improve stability and bioavailability.

Conclusion:
The current manuscript has reviewed the beneficial effects of liposomes and their
encapsulation methods in improving carrier sustainability of herbal-derived compounds for use in
the pharmaceutical and nutraceutical industry.
Synthesis and Applications of Nanoparticles: State of the Art and Future
Perspective
Authors: Shukla Smriti , Sharma Mitali , Yadav Sapna , Raghupathy Avinash , Shukla Kartikeya , Varma Ajit , Mishra Arti 
Published: February 2021

:
Nanoparticles are being extensively studied these days to grab more knowledge on how
they can be used in various fields to increase the yield and hence be beneficial for biotic components
of the ecosystem. Chemicals being used in agriculture have caused a lot of damage to the soil
and water quality along with the crops, ultimately affecting human health severely. Better alternatives
are thus required to achieve higher yields with a better quality of crop plants that enhance
human health. A variety of nanoparticles exist in nature, while others have been manufactured accidentally
or engineered purposefully. These nanoparticles can play many beneficial roles in crop
plants, increasing the yield of crops and the quality of the grains. They can be applied at various
stages and for different doses. The effect that they exhibit would be dependent on many factors.
Different nanoparticles have diverse effects on different plants. Some nanoparticles may be beneficial
to one species of crop plant and may be disadvantageous to the other ones. Therefore, an
elaborative study is required for all the types of nanoparticles exhibiting their advantageous and
disadvantageous impacts on different species of crop plants for the dose and stage in which they
have been applied. This review explains that the different types of nanoparticles are categorized
based on their manufacture and the different effects they cause in different plant species. More research
knowledge works are yet to be obtained before using nanoparticles in crop plants since the
way they affect human health is a serious matter of concern.
The Association Between Logging Steps Using a Website, App, or Fitbit and Engaging With the 10,000 Steps Physical Activity Program: Observational Study
Authors: Rayward Anna T , Vandelanotte Corneel , Van Itallie Anetta , Duncan Mitch J 
Published: February 2021

Background
Engagement is positively associated with the effectiveness of digital health interventions. It is unclear whether tracking devices that automatically synchronize data (eg, Fitbit) produce different engagement levels compared with manually entering data.

Objective
This study examines how different step logging methods in the freely available 10,000 Steps physical activity program differ according to age and gender and are associated with program engagement.

Methods
A subsample of users (n=22,142) of the free 10,000 Steps physical activity program were classified into one of the following user groups based on the step-logging method: Website Only (14,617/22,142, 66.01%), App Only (2100/22,142, 9.48%), Fitbit Only (1705/22,142, 7.7%), Web and App (2057/22,142, 9.29%), and Fitbit Combination (combination of web, app, and Fitbit; 1663/22,142, 7.51%). Generalized linear regression and binary logistic regression were used to examine differences between user groups’ engagement and participation parameters. The time to nonusage attrition was assessed using Cox proportional hazards regression.

Results
App Only users were significantly younger and Fitbit user groups had higher proportions of women compared with other groups. The following outcomes were significant and relative to the Website Only group. The App Only group had fewer website sessions (odds ratio [OR] −6.9, 95% CI −7.6 to −6.2), whereas the Fitbit Only (OR 10.6, 95% CI 8.8-12.3), Web and App (OR 1.5, 95% CI 0.4-2.6), and Fitbit Combination (OR 8.0; 95% CI 6.2-9.7) groups had more sessions. The App Only (OR −0.7, 95% CI −0.9 to −0.4) and Fitbit Only (OR −0.5, 95% CI −0.7 to −0.2) groups spent fewer minutes on the website per session, whereas the Fitbit Combination group (OR 0.2, 95% CI 0.0-0.5) spent more minutes. All groups, except the Fitbit Combination group, viewed fewer website pages per session. The mean daily step count was lower for the App Only (OR −201.9, 95% CI −387.7 to −116.0) and Fitbit Only (OR −492.9, 95% CI −679.9 to −305.8) groups but higher for the Web and App group (OR 258.0, 95% CI 76.9-439.2). The Fitbit Only (OR 5.0, 95% CI 3.4-6.6), Web and App (OR 7.2, 95% CI 5.9-8.6), and Fitbit Combination (OR 15.6, 95% CI 13.7-17.5) groups logged a greater number of step entries. The App Only group was less likely (OR 0.65, 95% CI 0.46-0.94) and other groups were more likely to participate in Challenges. The mean time to nonusage attrition was 35 (SD 26) days and was lower than average in the Website Only and App Only groups and higher than average in the Web and App and Fitbit Combination groups.

Conclusions
Using a Fitbit in combination with the 10,000 Steps app or website enhanced engagement with a real-world physical activity program. Integrating tracking devices that synchronize data automatically into real-world physical activity interventions is one strategy for improving engagement.