bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parenting Berbasis Desa (PAREDES) dalam Sinergitas Ekonomi Keluarga pada Masyarakat Desa Oro-Oro Ombo Kota Batu Jawa Timur
Authors: Setiawan Eko , Jannah Shofiatul 
Published: September 2021

Pengabdian kepada masyarakat adalah salah satu bagian dari thridharma perguruan tinggi yang harus dilaksanakan oleh seluruh dosen dan sivitas akademika lainnya untuk terlibat dalam kegiatan tersebut. Universitas Islam Malang telah mendukung program pengabdian kepada masyarakat dengan pendanaan internal yang dilaksanakan di seluruh wilayah Indonesia pada tahun 2021. Program ini telah mengintegrasikan program parenting berbasis desa dalam sinergitas ekonomi keluarga berupa sosialisasi dan pendampingan parenting berbasis desa yang dilaksanakan secara berkelanjutan selama tiga bulan. Dengan metode RRA (Rapid Rural Appraisal) yaitu metode untuk mendapatkan data secara akurat untuk memahami kondisi pedesaan pada tingkat komunitas lokal dan juga PRA (Participatory Rural Appraisal) yaitu sebuah metode untuk mempelajari kondisi pedesaan dari, dengan dan oleh masyarakat desa itu sendiri. Adapun lokasi adalah desa Oro-oro Ombo Kota Batu Jawa Timur yang merupakan kota wisata. Materi yang disampaikan adalah parenting dalam meningkatkan kualitas Pendidikan keluarga. Adapun hasil yang didapatkan adalah kesadaran orang tua terhadap Pendidikan, pola asuh pengasuhan anak serta membangun minesite bahwa pendidikan merupakan investasi pembangunan nasional. Community service is one part of higher education thridharma that must be carried out by all lecturers and other academicians to be involved in these activities. The Islamic University of Malang has supported community service programs with internal funding which will be implemented throughout Indonesia in 2021. This program has integrated village-based parenting programs into family economic synergy in the form of village-based parenting socialization and assistance which is carried out continuously for three months. With the RRA (Rapid Rural Appraisal) method, which is a method for obtaining accurate data to understand rural conditions at the local community level and also PRA (Participatory Rural Appraisal), which is a method for studying rural conditions from, with and by the village community itself. The location is the village of Oro-oro Ombo, Batu City, East Java, which is a tourist city. The material presented is parenting in improving the quality of family education. As for the results obtained, the parents' awareness of education, parenting, and building a minesite that education is an investment in national development.
Degradation of 17β-estradiol by UV/persulfate in different water samples
Authors: Zhu Yunjie , Shao Yanan , Wei Min , Yu Kefu , Zhang Yuanyuan , Huang Jianping , Yin Xinyue 
Published: September 2021

Abstract
Sulfate radical (•SO4−)-based advanced oxidation processes are widely used for wastewater treatment. This study explored the potential use of UV/persulfate (UV/PS) system for the degradation of 17β-estradiol (E2). The pH of the reaction system can affect the degradation rate of E2 by UV/PS and the optimum pH was 7.0; Br− and Cl− in water can promote the degradation rate, HCO3− has an inhibitory effect on the reaction, SO42− and cations (Na+, Mg2+, K+) have no effect on the degradation rate. The degradation of E2 by UV/PS was a mineralization process, with the mineralization rate reaching 90.97% at 8 h. E2 in the UV/PS system was mainly degraded by hydroxylation, deoxygenation, and hydrogenation. E2 reaction sites were mainly located on benzene rings, mainly carbonylation on quinary rings, and bond breakage between C10 and C5 resulted in the removal of benzene rings and carboxyl at C2 and C3 sites. In the presence of halogen ions, halogenated disinfection by-products were not formed in the degradation process of E2 by UV/PS. E2 in the UV/PS system could inhibit the formation of bromate. The results of this study suggest that UV/PS is a safe and reliable method to degrade E2.
Systematic review of the relative concentrations of noroviruses and fecal indicator bacteria in wastewater: considerations for use in quantitative microbial risk assessment
Authors: Hamadieh Zelfa , Hamilton Kerry A. , Silverman Andrea I. 
Published: September 2021

Abstract
Human noroviruses are a leading cause of food- and water-borne disease, which has led to an interest in quantifying norovirus health risks using quantitative microbial risk assessment (QMRA). Given the limited availability of quantitative norovirus data to input to QMRA models, some studies have applied a conversion factor to estimate norovirus exposure based on measured fecal indicator bacteria (FIB) concentrations. We conducted a review of peer-reviewed publications to identify the concentrations of noroviruses and FIB in raw, secondary-treated, and disinfected wastewater. A meta-analysis was performed to determine the ratios of norovirus-FIB pairs in each wastewater matrix and the variables that significantly impact these ratios. Norovirus-to-FIB ratios were found to be significantly impacted by the norovirus genotype, month of sample collection, geographic location, and the extent of wastewater treatment. Additionally, we evaluated the impact of using a FIB-to-virus conversion factor in QMRA and found that the choice of conversion ratio has a great impact on estimated health risks. For example, the use of a conversion ratio previously used in the World Health Organization Guidelines for the Safe Use of Wastewater, Excreta and Greywater predicted health risks that were significantly lower than those estimated with measured norovirus concentrations used as inputs. This work emphasizes the gold standard of using measured pathogen concentrations directly as inputs to exposure assessment in QMRA. While not encouraged, if one must use a FIB-to-virus conversion ratio to estimate norovirus dose, the ratio should be chosen carefully based on the target microorganisms (i.e., strain, genotype, or class), prevalence of disease, and extent of wastewater treatment.
Study on the proportion and flow path of Yangtze River water diversion into Taihu Lake
Authors: Hu Zhibing , Yong Pang , Ruichen Xu , Yuan Liu 
Published: September 2021

Abstract
The purpose of this study is to quantify the proportion and flow path of the water diversion from Yangtze River (YRD) into Taihu Lake. Based on the analysis of rainfall and data of Taihu basin in the recent 30 years, a 1-D hydrodynamic model of the main inflow river network area of Taihu basin was constructed, coupled the convection-diffusion model with conservative material, the characteristics of YRD and the water inflow into Taihu Lake (WITL) in three typical years were calculated. The results show that the YRD has shown a significant upward trend in the past 30 years, accounting for 26.4, 35.6 and 42% of the total WITL in three typical years of wet, normal and dry conditions respectively. From the perspective of space, Taige River is the largest river in the western part of the lake that is affected by the river diversion (35%–72%), and Wuxi River is the smallest (1–3%). In addition, the primary flow path of YRD to Taihu Lake was through the Wuyi River and Lake Gehu from the water diversion station west of the Zao River.
Designing of a novel polyvinylidene fluoride/TiO2/UiO-66-NH2 membrane with photocatalytic antifouling properties using modified zirconium-based metal-organic framework
Authors: Li Yi-Jing , Chen Gui-E , Liu Lian-Jing , Xu Zhen-Liang , Xu Sun-Jie , Xie Huan-Yin , Chen Zhen , Wan Jia-Jun 
Published: September 2021

Abstract
Novel polyvinylidene fluoride/TiO2/UiO-66-NH2 (PVDF/TiUN) membranes were produced by the delay phase separation method via introducing the TiO2/UiO-66-NH2 (TiUN) nanocomposite into PVDF casting solution. Interconnection of TiO2 and UiO-66-NH2 improved photocatalysis capacity and endowed PVDF/TiUN membranes with self-cleaning capability. Quantitative measurements showed that, firstly, PVDF/TiUN membranes exhibited improved photodegradation kinetics and efficiency (up to 88.1%) to Rhodamine B (RhB). Secondly, the performances of bovine serum albumin (BSA) rejection and permeation of PVDF/TiUN membranes outperformed those of other check samples, indicating enhanced hydrophilicity. Thirdly, rejection rate of BSA reached a breathtaking 98.14% and flux recovery ratio (FRR) of BSA reached a breathtaking 95.37%. Thus, given their excellent anti-contamination property and separation performance, the PVDF/TiUN membrane is very likely to be a novel water treatment membrane.
Catalytic ozonation for the removal of reactive black 5 (RB-5) dye using zeolites modified with CuMn2O4/gC3N4 in a synergic electro flocculation-catalytic ozonation process
Authors: Ikhlaq Amir , Zafar Mahrukh , Javed Farhan , Yasar Abdullah , Akram Asia , Shabbir Sidra , Qi Fei 
Published: September 2021

Abstract
This study aims to investigate the decolourization efficiency of reactive black 5 (RB-5) dye by using CuMn2O4/gC3N4 coated zeolites (zeolite 4A) for the first time in a hybrid electro-flocculation-catalytic ozonation process. A comparison between various treatment options such as electro-flocculation, electro-flocculation in the presence of a catalyst, and catalytic ozonation in combination with electro-flocculation was explored. Moreover, the effect of different factors such as pH, time, catalyst dose, ozone dose, radical scavenger, and voltage has been studied in each treatment option mentioned earlier. The results indicated that the best treatment option was found to be catalytic ozonation in combination with electro-flocculation with removal efficiency (RE) of 90.31% at pH 10 after 30 min of the treatment process. The hydroxyl radical scavenger effect indicated that the synergistic catalytic process follows a radical mechanism. It is therefore concluded that CuMn2O4/gC3N4–zeolite catalysts in synergic electro-flocculation-catalytic ozonation process may be effectively used for the treatment of textile wastewaters.
Recent Advances in Theranostic Applications of Nanomaterials in Cancer
Authors: Ahmed Faraha , Khan Mohammad Ahmed , Haider Nafis , Ahmad Mohammad Zaki , Ahmad Javed 
Published: September 2021

:
Early detection and accurate monitoring are two critical factors affecting the outcome of anticancer
therapy. However, both these factors are affected by the limitations of conventional approaches of diagnosis
and treatment. Nanomedicine has progressively offered a scientific solution in improved delivery and better diagnosis
of various cancers, thus providing a targeted treatment approach. With the advances in the field, simultaneous
delivery and diagnosis are becoming a reality. The present manuscript discusses various drug delivery
challenges, provides the scope for theranostic nanomaterials in the diagnosis and treatment of cancer. The clinical
and translational potential of theranostic nanomedicine and the future directions for further research are also
presented in the manuscript.
Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase and Leukotrienes
Authors: Saxena Anil Kumar , Nandi Sisir , Dey Rishita , Dey Sudatta , Samadder Asmita 
Published: September 2021

Background:Cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes catalyze the production of pain mediators like Prostaglandins (PGs) and Leukotrienes (LTs), respectively from arachidonic acid.Introduction:The COX and LOX enzyme modulators are responsible for the major PGs and LTs mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer’s disease, neuropathy and Cardiovascular Syndromes (CVS). Many synthetic Nonsteroidal Anti- Inflammatory Drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting, hyperacidity, gastrointestinal ulcers, CVS, etc.Methods:The natural inhibitors of pain mediators have great acceptance worldwide due to fewer side effects on long-term uses. The present review is an extensive study of the advantages of plantbased vs synthetic inhibitors.Results:These natural COX and LOX inhibitors control inflammatory response without causing side-effect-related complicacy.Conclusion:Therefore, the natural COX and LOX inhibitors may be used as alternative medicines for the management of pain and inflammation due to their less toxicity and resistivity.
Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike
Receptor Binding Domains and Non-structural Proteins - A Review
Authors: Macabeo Allan Patrick , Quimque Mark Tristan , Notarte Kin Israel , Adviento Xela Amor , Cabunoc Mikhail Harvey , de Leon Von Novi , delos Reyes Felippe Steven Louis , Lugtu Eiron John , Manzano Joe Anthony , Monton Sofia Nicole , Muñoz John Emmanuel , Ong Katherine Denise , Pilapil Delfin Yñigo , Roque Vito , Tan Sophia Morgan , Lim Justin Allen 
Published: September 2021

:
The ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic
has been proven to be more severe than the previous coronavirus outbreaks due to the virus’
high transmissibility. With the emergence of new variants, this global phenomenon took a more
dramatic turn, with many countries recently experiencing higher surges of confirmed cases and
deaths. On top of this, the inadequacy of effective treatment options for COVID-19 aggravated the
problem. As a way to address the unavailability of target-specific viral therapeutics, computational
strategies have been employed to hasten and systematize the search. The objective of this review is
to provide initial data highlighting the utility of polyphenols as potential prophylaxis or treatment
for COVID-19. In particular, presented here are virtually screened polyphenolic compounds which
showed potential as either antagonists to viral entry and host cell recognition through binding with
various receptor-binding regions of SARS-CoV-2 spike protein or as inhibitors of viral replication
and post-translational modifications through binding with essential SARS-CoV-2 non-structural
proteins.
Neuroinflammation in Alzheimer’s Disease: Focus on NLRP1 and NLRP3 Inflammasomes
Authors: de Brito Toscano Eliana C. , Rocha Natalia P. , Lopes Beatriz N. A. , Suemoto Claudia K. , Teixeira Antonio L. 
Published: September 2021

Background:
Alzheimer’s disease (AD) is the main cause of dementia worldwide. The
definitive diagnosis of AD is clinicopathological and based on the identification of cerebral deposition
of Amyloid β (Aβ) plaques and neurofibrillary tangles. However, the link between amyloid
cascade and depositions of phosphorylated tau (p-tau) is still missing. In this scenario,
inflammasomes might play a relevant role. Experimental models of AD have suggested that Aβ
accumulation induces, through microglia, activation of the NLRP3 inflammasome. This activation
contributes to the dissemination of Aβ and p-tau, as well as to hyperphosphorylation of tau. Also,
in experimental models, NLPR1 promoted neuronal pyroptosis. There are neither comprehensive
neuropathologic characterization nor clinicopathologic studies evaluating the NLRP1 and NLRP3
inflammasomes in subjects with AD.

Objective:
The current mini-review aims to summarize recent and promising findings on the role
of NLRP1 and NLRP3 signaling in the pathophysiology of AD. We also sought to highlight the
knowledge gap in patients with AD, mainly the lack of clinicopathologic studies on the interaction
among inflammasomes, Aβ/tau pathology, and cognitive decline.
SARS-Coronavirus 2, A Metabolic Reprogrammer: A Review in the Context
of the Possible Therapeutic Strategies
Authors: Veettil M. , Gopi P. , Anju T.R. , Pillai V.S. 
Published: September 2021

:
Novel coronavirus, SARS-CoV-2, is advancing at a staggering pace to devastate the
health care system and foster concerns over public health. In contrast to the past outbreaks, coronaviruses
are not clinging themselves as a strict respiratory virus. Rather, becoming a multifaceted
virus, it affects multiple organs by interrupting a number of metabolic pathways leading to significant
rates of morbidity and mortality. Following infection, they rigorously reprogram multiple
metabolic pathways of glucose, lipid, protein, nucleic acid, and their metabolites to extract adequate
energy and carbon skeletons required for their existence and further molecular constructions inside
a host cell. Although the mechanism of these alterations is yet to be known, the impact of these
reprogramming is reflected in the hyperinflammatory responses, so called cytokine storm and
the hindrance of the host immune defence system. The metabolic reprogramming during SARSCoV-
2 infection needs to be considered while devising therapeutic strategies to combat the disease
and its further complication. The inhibitors of cholesterol and phospholipids synthesis and cell
membrane lipid raft of the host cell can, to a great extent, control the viral load and further infection.
Depletion of energy sources by inhibiting the activation of glycolytic and hexosamine biosynthetic
pathways can also augment antiviral therapy. The cross talk between these pathways also necessitates
the inhibition of amino acid catabolism and tryptophan metabolism. A combinatorial
strategy that can address the cross talks between the metabolic pathways might be more effective
than a single approach, and the infection stage and timing of therapy will also influence the effectiveness
of the antiviral approach. We herein focus on the different metabolic alterations during the
course of virus infection that help exploit the cellular machinery and devise a therapeutic strategy
that promotes resistance to viral infection and can augment body’s antivirulence mechanisms. This
review may cast light on the possibilities of targeting altered metabolic pathways to defend against
virus infection in a new perspective.
Therapeutic Approaches for the Management of Autoimmune Disorders
via Gene Therapy: Prospects, Challenges and Opportunities
Authors: Sindhu Rakesh K. , Rahman Md. Habibur , Madaan Piyush , Chandel Parteek , Akter Rokeya , Adilakshmi Griddaluri 
Published: September 2021

Background:
Autoimmune diseases are the diseases that result due to the overactive immune
response, and comprehend systemic autoimmune diseases like Rheumatoid Arthritis (RA),
Sjӧgren’s Syndrome (SS), and organ-specific autoimmune diseases like type-1 diabetes mellitus
(T1DM), Myasthenia Gravis (MG), and Inflammatory Bowel Disease (IBD). Currently, there is no
long-term cure; but, several treatments exist which retard the evolution of the disease, embracing
gene therapy, which has been scrutinized to hold immense aptitude for the management of autoimmune
diseases.

Objective:
The review highlights the pathogenic mechanisms and genes liable for the development
of autoimmune diseases, namely T1DM, type-2 diabetes mellitus (T2DM), RA, SS, IBD, and MG.
Furthermore, the review focuses on investigating the outcomes of delivering the corrective genes
with their specific viral vectors in various animal models experiencing these diseases to determine
the effectiveness of gene therapy.

Methods:
Numerous review and research articles emphasizing the tremendous potential of gene
therapy in the management of autoimmune diseases were procured from PubMed, MEDLINE,
Frontier, and other databases and thoroughly studied for writing this review article.

Results:
The various animal models that experienced treatment with gene therapy have displayed
regulation in the levels of proinflammatory cytokines, infiltration of lymphocytes, manifestations
associated with autoimmune diseases, and maintained equilibrium in the immune response, thereby
compete with the progression of autoimmune diseases.

Conclusion:
Gene therapy has revealed prodigious aptitude in the management of autoimmune diseases
in various animal studies, but further investigation is essential to combat the limitations associated
with it and before employing it on humans.
Me and My Baby Are One; The Mother's Experience of Continuous Kangaroo
Care: A Qualitative Study
Authors: Mohammadi Marzieh , Sattarzadeh Niloufar , Valizadeh Leila , Heidarzadeh Mohammad , Hosseini Mohammadbagher , Hakimi Sevil 
Published: September 2021

Introduction:
Infant hospitalization in the Neonatal Intensive Care Unit (NICU) causes
the separation of mother from her infant. Kangaroo Care (KC) is a bio-care method for preterm
newborns. This study was conducted with the aim of investigating the experiences of mothers that
could be helpful for the further development and expansion of continuous kangaroo mother care
(C-KMC).

Material and Method:
This is a qualitative study with a content analysis approach. In order to
collect data, in-depth individual interviews were conducted with thirteen mothers who were able to
care for their infants in the form of C-KMC. The sampling was of purposeful type; the interviews
were recorded, and their contents were written accurately and word by word.

Findings:
Analysis of mothers' experiences led to the emergence of three main themes of mother’s
positive attitude, facilitator factors and barriers to perform C-KMC.

Conclusion:
The results of this study showed that performing KMC caused a sense of calm, empowerment,
and satisfaction of the mother and had many medical benefits for the infant. On the
other hand, physicians and nurses can act as facilitators or barriers based on the support they make
from mothers. Also, the support of the spouse and family play an important role in continuing to
perform the continuous KMC by the mother.
Oral Surgical and Haematological Management in a Female Patient with Turner Syndrome and Moderate Haemophilia A: Clinical Observation and Case Report
Authors: Lewandowski Bogumił , Myszka Aleksander , Brodowski Robert , Czenczek-Lewandowska Ewelina , Odnoczko Edyta , Windyga Jerzy 
Published: September 2021

Introduction:
Turner syndrome patients are at higher risk of having X-linked recessive disorders that could have serious clinical implications. Somatic abnormalities that may coexist with coagulation disorders determine the medical procedure approaches.

Case Report:
We report a 29-year-old female showing dysmorphia, distinctive physical features, and coagulation disorder, referred for maxillofacial surgery. Based on clinical symptoms, the patient was diagnosed with Turner Syndrome, and haemophilia A. Karyotyping confirmed classical monosomy X in all analysed blood cells. Molecular studies revealed hemizygous point mutation c.5096A>G (p.Tyr1699Cys) in Factor VIII gene, in exon 14. This missense mutation disturbs the interaction of Factor VIII with the von Willebrand factor, causing moderate haemophilia in the proband. The article presents the clinical history and preparation of our patient for oral surgical and dental surgery treatment.

Conclusion:
Turner syndrome patients require special attention due to the higher probability of congenital haemorrhagic diathesis. Maxillofacial surgery interventions in Turner syndrome and congenital haemorrhagic diathesis patients require individual patient preparation preventing post-extraction bleeding and ensuring proper local haemostasis.