bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Continuous Renal Replacement Therapy in a Community Health System
Authors: Schaffer Patrick , Chowdhury Raad , Jordan Kim , DeWitt Jordan , Elliott John , Schroeder Kevin 
Published: November 2021

Objective Continuous renal replacement therapy (CRRT) is commonly used in critically ill, hemodynamically unstable patients with acute kidney injury (AKI). This procedure is resource intensive with reported high in-hospital mortality. We evaluated mortality with CRRT in our healthcare system and markers associated with decreased survival. Methods A retrospective cohort study collected data on patients 18 years or older, without prior history of end stage kidney disease (ESKD), who received CRRT in the intensive care units at one of three hospitals in our health system in Columbus, OH from July 1, 2016 to July 1, 2019. Data included demographics, presenting diagnosis, comorbidities, laboratory markers, and patient disposition. In-hospital mortality rates and sequential organ failure assessment (SOFA) scores were calculated. We then compared information between two groups (patients who died during hospitalization and survivors) using univariate comparisons and multivariate logistic regression models. Results In-hospital mortality was 56.8% (95%CI: 53.4–60.1) among patients who received CRRT. Mean SOFA scores did not differ between survival and mortality groups. The odds for in-patient mortality were increased for patients age ≥60 (OR = 1.74, 95%CI: 1.23-2.44), first bilirubin >2 mg/dL (OR = 1.73, 95%CI: 1.12-2.69), first creatinine < 2 mg/dL (OR = 1.57, 95%CI: 1.04–2.37), first lactate > 2 mmol/L (OR = 2.08, 95%CI: 1.43-3.04). The odds for in-patient mortality were decreased for patients with cardiogenic shock (OR = .32, 95%CI: .17-.58) and hemorrhagic shock (OR = .29, 95%CI: .13-.63). Conclusions We report in-hospital mortality rates of 56.8% with CRRT. Unlike prior studies, higher mean SOFA scores were not predictive of higher in-hospital mortality in patients utilizing CRRT.
Experimental study on two-body and three-body abrasive wear behaviour of jute-natural rubber flexible green composite
Authors: Mahesh Vishwas , Mahesh Vinyas , Joladarashi Sharnappa , Kulkarni Satyabodh M 
Published: November 2021

The use of laboratory testing has become more significant to assess abrasion resistance in flexible reinforcement of armour and car structural components. In this study, compliant composite with constituents as woven jute fabric and natural rubber encapsulated in an NR-based B stage cured prepreg were tested for wear due to abrasion under two- and three-body conditions. Flexible composites are fabricated in three different configurations namely Jute/Rubber/Jute, Jute/Rubber/Rubber/Jute and Jute/Rubber/Jute/Rubber/Jute. The present study makes use of abrasive paper with a grit size of 60 and silica sand with size 250 μm as the abrasive medium for two- and three-body abrasion tests, respectively, and the specific rate of wear is calculated. Though the wear trend of the composites follows a similar pattern in the case of two- and three-body wear, the mechanisms governing the wear are found to be different. The morphology of the worn surface is studied with the aid of a scanning electron microscope.
Near infrared spectroscopic and aquaphotomic evaluation of the efficiency of solar dehydration processes in pineapple slices
Authors: Cattaneo Tiziana MP , Cutini Maurizio , Cammerata Alessandro , Stellari Annamaria , Marinoni Laura , Bisaglia Carlo , Brambilla Massimo 
Published: November 2021

Parallel transformation tests on pineapple slices using two micro drying plants (M1 and M2) operating with solar energy were carried out. Method M1 consisted of an active fan at the top, whose ventilation rate depended on the internal temperature. Method M2 had a continuously working fan at the bottom. The dehydration performance of these two micro-plants was compared by collecting spectra from pineapple slices in reflectance mode (900–1600 nm) at three different times: (0) process start, (1) during the process [48 h] and (2) process end [56 h]. Simultaneously, dry matter, titratable acidity (SH°), pH and aw (water activity) were measured. For these parameters, significant differences ( p < 0.05) were detected between the fresh (t = 0) and the dried product (t = 56). Near infrared (NIR) spectroscopic analysis was carried out according to previously published methods. Spectral data in the wavelength region from 1300 to 1550 nm underwent statistical processing to perform aquaphotomics evaluation and chemometric analysis using PCA (Principal Component Analysis) and LDA (Linear Discriminant Analysis). The aquagrams highlighted differences among fresh, half-dried and dried slices where water molecules were highly organized between the water matrix coordinates C1 to C3 at t = 0 and C2 to C6 for the other evaluated times. The PCA could explain about 98% of the total variance in the PC1–PC3 scores plot. And the additional LDA classified the NIR spectra with an accuracy of 100, 98 and 83% for t = 0, t = 56-M1 and t = 56-M2, respectively. Such preliminary results suggest the applicability of Aquaphotomics and chemometrics for the continuous monitoring of fruit drying processes using an adequate NIR probe. Further experiments are already in progress.
Seeing it clearly: How to use graphics to guide collaborative consultation in pregnancy
Authors: Keightley Philip , DiBella Ilona , Sved Williams Anne 
Published: November 2021

Objective This study aims to examine the use of decision aids which may improve shared decision making through an exploration of risk apprehension and modes of collaborative communication. Conclusions Decision aids such as graphics have a key role in facilitating shared treatment decision making, perhaps particularly in perinatal mental health care. They are most useful within a trusting, two-way conversation.
Cytokine profile in tear and aqueous humor of primary open-angle patients as a prognostic factor for trabeculectomy outcome
Authors: Burgos-Blasco Barbara , Vidal-Villegas Beatriz , Saenz-Frances Federico , Fernandez-Vigo Jose I , Andres-Guerrero Vanessa , Espino Laura , Garcia-Feijoo Julian , Martinez-de-la-Casa Jose M 
Published: November 2021

Objective To evaluate the cytokine profile in tear and aqueous humor in primary open-angle glaucoma before trabeculectomy and correlate preoperative cytokine levels with the surgical outcome. Methods Prospective study. Twenty-nine patients with primary open-angle glaucoma undergoing primary trabeculectomy were included. Levels of 27 cytokines were measured in tear an aqueous humor using the Bio-Plex Pro Human Cytokine 27-Plex Immunoassay kit (Bio-Rad Laboratories, Hercules, CA, USA). Results 29 patients who underwent trabeculectomy were included and their first-year follow-up visits were recorded. Mean age was 76.0 ± 7.0 years (range 56–84), mean intraocular pressure was 18.2 ± 3.6 mmHg and mean number of topical medications was 2.3 ± 0.9. At the one-year visit, 5 patients were classified as surgical failure. In aqueous humor, preoperative cytokine levels of regulated on activation normal T cell expressed and secreted (RANTES) were significantly higher in those patients with surgical failure at one year. IL-8 in tear and interferon gamma-induced protein (IP-10) in aqueous humor correlated positively with one-year IOP reduction. No statistically significant correlations were found with changes in visual field mean defect or global peripapillary retinal nerve fiber layer thickness (all, p >0.05). Conclusions Preoperative RANTES levels in aqueous humor as well as other cytokines could serve as useful biomarkers for trabeculectomy outcome.
Beliefs Toward Smoking and COVID-19, and the Pandemic Impact on Smoking Behavior and Quit Intention: Findings from a Community-Based Cross-Sectional Study in Jordan
Authors: Al-Tammemi Ala’a B. , Barakat Muna , Al Tamimi Dua’a , Alhallaq Sami A. , Al Hasan Dima M. , Khasawneh Ghena M. , Naqera Khalil Abu , Jaradat Raghad M. , Farah Fadi W. , Al-Maqableh Hindya O. , Abuawad Alaa , Othman Bayan , Tarhini Zeinab , Odeh Hamza , Khatatbeh Moawiah , Akour Amal , Aljaberi Musheer A. , Kolozsvári László Róbert 
Published: November 2021

Background The relationship between smoking and coronavirus disease-2019 (COVID-19) is still topical with mixed epidemiological evidence. However, the pandemic may affect people’s beliefs toward smoking as well as their smoking behavior and quit intentions. Considering high smoking rates in Jordan, our current study aimed to assess the following domains in a community-based sample from Jordan: (i) the beliefs that surround smoking/vaping and COVID-19 and (ii) the pandemic impact on smoking behavior and quit intention. Methods A cross-sectional study was conducted in Jordan from March 9 to March 16, 2021, utilizing a web-based structured questionnaire. The questionnaire comprised 13 items on sociodemographic, health, and smoking profiles, 14 items to assess beliefs surrounding COVID-19 and the use of combustible cigarettes (CCs), waterpipe (WP), and electronic cigarettes (ECs), and 12 items to assess the pandemic impact on smoking behavior and quit intention. Results Of 2424 survey respondents who participated in our study, there were 1163 never-smokers, 1044 current smokers, and 217 ex-smokers. The mean age of participants was 35.2 years (SD: 11.06). Most participants have reported anti-smoking beliefs with around 72.9% believed that WP smoking is related to the risk of contracting COVID-19. Also, 71.7% believed that smoking CC may worsen the COVID-19 clinical course, while 74.1% of respondents believed that smoking has no protective effect against COVID-19. During the pandemic, about 28.1% and 19.3% of current smokers reported increased or reduced smoking, respectively. Besides, 459 current smokers have expressed their plans/intention to quit smoking during the pandemic, of whom 27.5% (n = 126) confirmed that the driving force for their decision is a COVID-19-related reason, such as self-protection (n = 123) and protection of family members (n = 121) which were the most cited reasons. Also, around 63 participants have successfully ceased smoking during the pandemic. However, only 22 of them reported that the main driving motivation of their successful quit attempt was the COVID-19 pandemic. Conclusion Most participants’ beliefs and attitudes were against smoking during the pandemic. Nevertheless, the double-edged effect of the pandemic on smoking habits should be carefully considered, and reliable anti-smoking measures should be strengthened and sustained in the country.
Persons living with HIV who do not smoke cigarettes: A comparison of ex-smokers and never smokers
Authors: Shuter Jonathan , Hosgood H. Dean , Nardin Shaundell , Weinberger Andrea H. 
Published: November 2021

Background and Aims Approximately half of persons living with HIV (PLWH) in the US smoke cigarettes. Large surveys show that 16.9%–37.3% of PLWH are never smokers compared to 57.5% of US adults. Similar proportions of PLWH and general population adults describe themselves as ex-smokers (20.3% vs 21.9% respectively). Little research has been done to characterize PLWH non-smokers. In this study, we compared a group of well characterized PLWH ex-smokers (i.e., no cigarettes for at least 5 years) to PLWH never smokers with the aim of developing a clearer understanding of the characteristics of these groups and the differences between them. Design Cross-sectional interview study employing audio computer-assisted self-interview (ACASI). Setting Comprehensive HIV care center in New York City. Participants In 2018–2019, we recruited a sample of PLWH never smokers (N = 54) and long-term ex-smokers (no cigarettes for at least 5 years, N = 36). Non-smoking status of participants was verified by exhaled carbon monoxide. Measurements We collected a range of sociodemographic, historical, clinical, and psychobehavioral data pertaining to tobacco use. Results Compared to never smokers, ex-smokers were older, more likely to have heterosexually acquired HIV and less likely to have same-sex-acquired infection, more likely to have parents and/or siblings who smoked, more likely to have current smoker/s in their households, and more likely to have ever used marijuana, cocaine, and/or heroin. Conclusions We describe important demographic and sociobehavioral differences between PLWH never smokers and ex-smokers that may be useful in crafting an effective response to the cigarette smoking epidemic in US PLWH.
New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in Vitro Nanoparticle Cytotoxicity
Authors: Panov Vladimir , Bushueva Tatiana , Minigalieva Ilzira , Naumova Anna , Shur Vladimir , Shishkina Ekaterina , Sutunkova Marina , Gurviсh Vladimir , Privalova Larisa , Katsnelson Boris 
Published: November 2021

Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somewhat stronger effect of this kind. Along with cell hypertrophy developing in response to certain doses of SeO-NP and CuO-NP, our experiment also revealed doses causing a decrease in cell and cell-nucleus sizes. We observed both monotonic and different variants of nonmonotonic dose-response relationship. For the latter, we have succeeded in constructing adequate mathematical expressions based on the generalized hormesis paradigm that we had considered previously in respect of CdS-NP and PbS-NP cytotoxicity for cardiomyocites. It was demonstrated as well that combined toxicity of SeO-NP and CuO-NP is of different types depending on the outcome.
Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
Authors: Sornsuvit Chuleegone , Wientong Purida , Uitrakul Suriyon , Okonogi Siriporn , Katip Wasan 
Published: November 2021

Background Imipenem remains active against most Gram-positive and Gram-negative organisms. This study aimed to evaluate chemical stability of imipenem in 2 commonly used concentrations when stored in 3 various temperatures. Methods Imipenem injection powder was used to prepare 5 mL and 10 mg/mL of imipenem in .9% sodium chloride solution. Prepared solutions in PVC bags were stored at 25°C, 30°C, and 40°C. The solutions were investigated over 0, 1, 2, 3, 4, and 6 hours using HPLC analysis. The association between drug stability, temperature, and concentration was determined. Results The 5 mg/mL solutions of brand A and B imipenem mL were stable for 6 hours at 25°C, 30°C, and 40°C, respectively. For 10 mg/mL, the solution of brand A was stable for 3 hours and brand B was stable for 6 hours at 25°C. Also, brand A and B imipenem solutions at the concentration of 10 mg/mL were stable for less than 1 hour at 30°C and 40°C. Conclusion The stability of imipenem injection solution was affected by temperature and concentration. Increasing in temperature and drug concentration resulted in decreased stability of imipenem. Suitable temperature and drug concentration should be concerned when this drug is given by extended infusion.
Associations of self-reported chronic obstructive pulmonary disease with indicators of economic instability and stress – 16 states, 2017
Authors: Carlson Susan A , Wheaton Anne G , Liu Yong , Moore Latetia V , Eke Paul I , Croft Janet B , Greenlund Kurt J , Thomas Craig W 
Published: November 2021

Objectives To examine the association between chronic obstructive pulmonary disease status and indicators of economic instability and stress to better understand the magnitude of these issues in persons with chronic obstructive pulmonary disease. Methods Analyzed 2017 Behavioral Risk Factor Surveillance System data from 16 states that administered the ‘Social Determinants of Health’ module, which included economic instability and stress measures ( N = 101,461). Associations between self-reported doctor-diagnosed chronic obstructive pulmonary disease status and each measure were examined using multinomial logistic models. Results Adults with chronic obstructive pulmonary disease were more likely ( p < 0.001) than adults without to report not having enough money at month end (21.0% vs. 7.9%) or just enough money (44.9% vs. 37.2%); being unable to pay mortgage, rent, or utility bills (19.2% vs. 8.8%); and that often or sometimes food did not last or could not afford to eat balanced meals (37.9% vs. 20.6%), as well as stress all or most of the time (27.3% vs. 11.6%). Associations were attenuated although remained significant after adjustments for sociodemographic and health characteristics. Discussion Financial, housing, and food insecurity and frequent stress were more prevalent in adults with chronic obstructive pulmonary disease than without. Findings highlight the importance of including strategies to address challenges related to economic instability and stress in chronic obstructive pulmonary disease management programs.
Distal biceps repair through a single incision with the use of a knotless cortical button device: Mid-term results
Authors: Assiotis Angelos , French Jonathan , Edwards Gray , McCann Philip A , Chalk Naomi , Amirfeyz Rouin 
Published: November 2021

Background Distal biceps rupture presents with an increasing incidence and evidence suggests that although a surgical repair is not mandatory, it results in superior functional outcomes when compared to non-operative management. As implant technology has advanced, several devices have been utilised and studied in managing this pathology. We present our single-centre experience with the use of the ToggleLoc Ziploop reattachment device, a knotless cortical button implant, using a single-incision technique. Methods Retrospective series of 70 consecutive distal biceps tendon repairs, at a mean follow-up of 45.6 months after surgery, using a standardised single implant, single-incision technique, and post-operative rehabilitation programme. Results There was one (1.4%) re-rupture in our patient cohort. The range of motion was complete in all patients except for one patient who had symptomatic heterotopic ossification, causing limitation in pronation. Complications were minor with the commonest being transient neuropraxia of the lateral cutaneous nerve of the forearm. The mean Oxford elbow score was 46.9 out of 48, and the patient global impression of change scale was 7 out of 7 in 77% of cases. Conclusion Our data support this technique and implant combination when dealing with acute and chronic distal biceps tendon rupture.
Association between proteinuria and placental pathology in preeclampsia: A retrospective study
Authors: Genest Dominique Suzanne , Dal Soglio Dorothée , Girard Sylvie , Rey Evelyne 
Published: November 2021

Introduction: Preeclampsia develops due to placental insufficiency and systemic proinflammatory and antiangiogenic mediator release, with ensuing systemic endothelial dysfunction. Nephrotic-range proteinuria appears to be associated with worse pregnancy outcomes. The relationship between differing degrees of proteinuria and the severity of placental alterations has not been studied. Methods: This is a single-centre retrospective comparison of 150 singleton pregnancies complicated by preeclampsia and varying degrees of proteinuria. Maternal demographic, obstetrical and fetal outcome data were obtained from chart review. The placental histologic evaluations were performed by a placental pathologist blinded to all other clinical information. Results: Preeclamptic women with massive proteinuria had evidence of more severe maternal vascular malperfusion lesions. The severity of the lesions was progressive through mild, moderate and massive proteinuria. Women with massive proteinuria had a higher incidence of renal dysfunction and severe hypertension, and had earlier preterm deliveries compared to preeclamptic women with mild and moderate proteinuria (p < 0.05). Conclusion: Preeclampsia with more severe proteinuria is associated with a higher prevalence of placental maternal vascular malperfusion.
Primary Hyperoxaluria Type 1 (PH1) Presenting With End-Stage Kidney Disease and Cutaneous Manifestations in Adulthood: A Case Report
Authors: Poyah Penelope , Bergman Joel , Geldenhuys Laurette , Wright Glenda , Walsh Noreen M. , Hull Peter , Roche Kristina , West Michael L. 
Published: November 2021

Rationale: Primary hyperoxaluria (PH) is a rare autosomal recessive disorder more commonly diagnosed in children or adolescents. Owing to its rarity and heterogeneous phenotype, it is often underrecognized, resulting in delayed diagnosis, including diagnosis after end-stage kidney disease (ESKD) has occurred or recurrence after kidney-only transplantation. Case Presentation: A 40-year-old Caucasian Canadian woman with a history of recurrent nephrolithiasis since age 19 presented with ESKD and cutaneous symptoms. She had no known prior kidney disease and no family history of kidney disease or nephrolithiasis. Diagnosis: A diagnosis of primary hyperoxaluria type 1 (PH1) due to homozygous splice donor mutation (AGXT c.680+1G>A) was made with kidney and cutaneous pathology demonstrating calcium oxalate deposition and ultrasound suggestive of nephrocalcinosis. Interventions: She was initiated on frequent, high-efficiency, high-flux conventional hemodialysis and oral pyridoxine. Lumasiran was added 11 months later, after she developed bilateral swan-neck deformities. Outcomes: After 14 months of high-intensity dialysis and 3 months of lumasiran, there have been no signs of renal recovery, and extra-renal involvement has increased with progressive swan-neck deformities, reduced cardiac systolic function, and pulmonary hypertension. The patient has been waitlisted for kidney-liver transplantation. Teaching Points: This case report describes an adult presentation of PH1. The case highlights the importance of timely workup of metabolic causes of recurrent nephrolithiasis or nephrocalcinosis in adults which can be a presenting sign of PH and genetic testing for PH to facilitate early diagnosis and treatment especially in the era of novel therapeutics that may alter disease course and outcomes. The case also demonstrates the value of testing for PH in adults presenting with unexplained ESKD and a history of recurrent nephrolithiasis or nephrocalcinosis due to implications for organ transplantation strategy and presymptomatic family screening.