bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-coding RNAs as Novel Biomarkers in Cancer Drug Resistance
Authors: Yang Haixiu , Qi Changlu , Li Boyan , Cheng Liang 
Published: August 2021

Abstract:Chemotherapy is often the primary and most effective anticancer treatment; however, drug resistance remains a major obstacle to it being curative. Recent studies have demonstrated that non-coding RNAs (ncRNAs), especially microRNAs and long non-coding RNAs, are involved in drug resistance of tumor cells in many ways, such as modulation of apoptosis, drug efflux and metabolism, epithelial-to-mesenchymal transition, DNA repair, and cell cycle progression. Exploring the relationships between ncRNAs and drug resistance will not only contribute to our understanding of the mechanisms of drug resistance and provide ncRNA biomarkers of chemoresistance, but will also help realize personalized anticancer treatment regimens. Due to the high cost and low efficiency of biological experimentation, many researchers have opted to use computational methods to identify ncRNA biomarkers associated with drug resistance. In this review, we summarize recent discoveries related to ncRNA-mediated drug resistance and highlight the computational methods and resources available for ncRNA biomarkers involved in chemoresistance.
The Importance of Linkers in the Structure of PSMA Ligands
Authors: Uspenskaya Anastasia A. , Nimenko Ekaterina A. , Machulkin Aleksei E. , Beloglazkina Elena K. , Majouga Alexander G. 
Published: August 2021

:
Abstract: Cancer is one of the leading social problems of the modern world. Today prostate cancer is
the second leading cause of cancer deaths among men. Targeted drug delivery is widely used to treat
and diagnose prostate cancer. Conjugates selectively binding to prostate-specific membrane antigenbased
on urea ligands are being actively developed against this disease. The linker has a significant
influence on the biological activity of such conjugates. The linker performs a large number of functions,
and its modification is one of the key methods for creating the best pharmacological profile. This
review aims to discuss and analyze the main approaches to the method of introduction and synthesis of
linkers for this type of conjugates without a description of the influence of biologically active molecules,
as well as to establish the key modification methods that have a significant role on the structureactivity
relationship. For this purpose, a review of the current scientific literature was performed, both
for the conjugates under development and those already undergoing clinical trials. It was found that the
optimal structure is a linker containing an aliphatic fragment near the vector-molecule (n(CH2) = 3-6),
followed by a polypeptide chain consisting of 2 to 4 amino acid residues. The presence of a Phe-Phe
dipeptide chain or the introduction of negatively charged groups also has a positive effect. Ongoing
research in this field helps to establish the accurate effect of each linker fragment, and the development
of solid-phase synthesis methods makes it much easier to achieve this goal.
RYR1-Related Rhabdomyolysis: A Spectrum of Hypermetabolic States Due to Ryanodine Receptor Dysfunction
Authors: Kruijt Nick , den Bersselaar Luuk Van , Snoeck Marc , Kramers Kees , Riazi Sheila , Bongers Coen , Treves Susan , Jungbluth Heinz , Voermans Nicol 
Published: August 2021

:Variants in the ryanodine receptor-1 gene (RYR1) have been associated with a wide range of neuromuscular conditions, including various congenital myopathies and malignant hyperthermia (MH). More recently, a number of RYR1 variants, mostly MH-associated, have been demonstrated to contribute to rhabdomyolysis events not directly related to anesthesia in otherwise healthy individuals. This review focuses on RYR1-related rhabdomyolysis in the context of several clinical presentations (i.e., exertional rhabdomyolysis, exertional heat illnesses and MH), and conditions involving a similar hypermetabolic state, in which RYR1 variants may be present (i.e., neuroleptic malignant syndrome and serotonin syndrome). The variety of triggers that can evoke rhabdomyolysis, on their own or in combination, as well as the number of potentially associated complications, illustrates that this is a condition relevant to several medical disciplines. External triggers include but are not limited to strenuous physical exercise, especially if unaccustomed or performed under challenging environmental conditions (e.g., high ambient temperature or humidity), alcohol/illicit drugs, prescription medication (in particular statins, other anti-lipid agents, antipsychotics and antidepressants) infection, or heat. Amongst all patients presenting with rhabdomyolysis, genetic susceptibility is present in a proportion, with RYR1 being one of the most common genetic causes. Clinical clues for a genetic susceptibility include recurrent rhabdomyolysis, creatine kinase (CK) levels above 50 times the upper limit of normal, hyperCKemia lasting for 8 weeks or longer, drug/medication doses insufficient to explain the rhabdomyolysis event, and positive family history. For the treatment or prevention of RYR1-related rhabdomyolysis, the RYR1 antagonist dantrolene can be administered, both in the acute phase or prophylactically in patients with a history of muscle cramps and/or recurrent rhabdomyolysis events. Aside from dantrolene, several other drugs are being investigated for their potential therapeutic use in RYR1-related disorders. These findings offer further therapeutic perspectives for humans, suggesting an important area for future research.
Synthesis of Chromen-1-phenylpropan-1-one Derivatives and their Antidepressant/ Anticonvulsant Activities
Authors: Zhang Shan-Shan , Liu Wei-Hua , He Zhi-Wen , Tan Qiu-Wan , Guan Li-Ping 
Published: August 2021

Background:
Coumarin and chalcone are important secondary plant metabolites that exhibit
a range of biological activities. Accordingly, the synthetic derivatives and analogs of these molecules
have attracted attention as potential pharmacological agents

Objective:
This study aims to study new antidepressants with high biological activity and low side
effects, and to provide a basis for the treatment of epilepsy and depression.

Method:
In this study, a series of chalcone derivatives containing a coumarin moiety (2a–2s) were
designed, synthesized, and evaluated using classic antidepressant and anticonvulsant mouse models.

Results:
Forced swimming test results revealed that all but one of the compounds tested significantly
decreased immobility time at a dose of 10 mg/kg and exhibited some antidepressant activities. Furthermore,
compounds 2a, 2c, 2h, and 2k exhibited relatively high antidepressant effects in a dosedependent
manner from 10 to 30 mg/kg. Maximal electroshock seizure tests showed that compounds
2a, 2b, 2c, 2h, 2l, 2r, and 2s exhibited anticonvulsant activities at a dose of 30 mg/kg.

Conclusion:
Accordingly, compounds 2a, 2c, and 2h showed promise as antidepressant adjunct
therapy agents for treating depression in patients with epilepsy. Chromatographic neurochemical
analysis of the mouse brain tissue revealed that the antidepressant effects of the compounds may be
mediated by an increase in serotonin level.
Value of Magnetic Resonance Cholangiopancreatography in Santorinicele
and Wirsungocele
Authors: Zhao Xinzhu , Wan Xing , Luo Min , Du Mu , Xie Qiuxia , Zou Qian , Mei Yingjie , Liu Yubao 
Published: August 2021

Background:
Former studies showed that magnetic resonance cholangiopancreatography
(MRCP) is useful in diagnosing the presence of santorinicele; however, few studies have evaluated
MRCP in diagnosing wirsungocele and the association between pancreatitis and santorinicele
or wirsungocele. The purpose of the study was to explore the performance of MRCP in diagnosing
santorinicele and wirsungocele and investigate the potential association among pancreatitis, pancreas
divisum, and santorinicele or wirsungocele.

Method:
Sixty-five patients (mean age, 55.68 years; range, 11-82 years) with santorinicele or wirsungocele
were included and sorted into two groups: the santorinicele group (n = 48) and the wirsungocele
group (n = 17). All patients underwent MRCP. The images were evaluated for the appearance
and size of santorinicele or wirsungocele. The diagnostic sensitivity of MRCP was assessed.
Additionally, whether two groups are correlated with pancreas divisum or pancreatitis were
investigated.

Result:
The sensitivity of MRCP in detecting santorinicele and wirsungocele showed no difference
(68.8% and 76.5%, respectively). The proportion of patients who developed pancreatitis in
santorinicele and wirsungocele groups were 60.4% and 11.8%, respectively (p < 0.05). Pancreas divisum
accounted for 77.1% and 11.8% of the patients in the santorinicele and wirsungocele groups,
respectively (p < 0.05). Patients with santorinicele and pancreas divisum tended to be older when
they acquired pancreatitis.

Conclusion:
MRCP could be an alternative imaging method to detect cystic dilation of the pancreatic
duct. Pancreatitis is more common in patients with santorinicele than in those with wirsungocele.
Moreover, santorinicele is more closely associated with pancreatitis than with pancreas divisum.
Studies on Sodium Lauryl Sulphate-supported Thorium (IV) Phosphate: A
New Surfactant-supported Cation Exchange Resin, Useful in Water
Purification
Authors: Somya Amita , Singh Mamata 
Published: August 2021

Background:
With the increasing population and decreased quality of drinking water,
new materials and methods for the purification of water need to be developed. This study aims to
present a solution from pollution by proposing the synthesis method of sodium lauryl sulphate
(SLS)-supported thorium (IV) phosphate (ThP), its characterisation and disquisition of analytical
applications by executing dual separations of calcium.

Methods:
SLS ThP was synthesised by the sol-gel method. The synthesised exchanger was characterised
by physicochemical methods, such as powdered X-ray diffraction, scanning electron microscopy,
thermo-gravimetric-differential thermal analysis, EDAX and Fourier transform-infrared
study. Also, its competency towards the ion exchange processes and in analytical chemistry was
verified.

Results:
The prominent characteristic of SLS-supported ThP was its high ion exchange capacity for
sodium ions (3.10 meq/g), which is almost 2.5 times more than the exchange capacity of ThP, i.e.,
1.3 meq/g. The material resulted in a fibrous sheet that is thermally and mechanically stable but
poorly crystalline and shows selectivity towards Ca2+ and Hg2+ ions.

Conclusion:
The synthesised cation exchange material is thermally stable, showing drastically high
exchange capacity and selectivity towards Hg2+ and Ca2+ metal ions, which might be because of the
use of an anionic surfactant, SLS, while the synthesis of ThP plays a key role in enhancing the exchange
capacity and adsorption of specific metals. Therefore, based on the results obtained, the
above-said materials have applications in water purification processes and environmental pollution
control where removal of Hg2+ and Ca2+ is essential.
Advances and Challenges in Kidney Organoids
Authors: Sabapathy Vikram , Costlow Gabrielle , Venkatadri Rajkumar , Dogan Murat , Kumar Sanjay , Sharma Rahul 
Published: August 2021

:
The advent of organoids has renewed researchers' interest in in vitro cell culture systems.
A wide variety of protocols, primarily utilizing pluripotent stem cells, are under development
to improve organoid generation to mimic organ development. The complexity of organoids generated
is greatly influenced based on the method used. Understanding the process of kidney organoid
formation gives developmental insights into how renal cells form, mature, and interact with the adjacent
cells to form specific spatiotemporal structural patterns. This knowledge can bridge the gaps
in understanding in vivo renal developmental processes. Evaluating genetic and epigenetic signatures
in specialized cell types can help interpret the molecular mechanisms governing cell fate. In
addition, development in single-cell RNA sequencing, 3D bioprinting and microfluidic technologies
has led to better identification and understanding of a variety of cell types during differentiation
and designing of complex structures to mimic the conditions in vivo. While several reviews
have highlighted the application of kidney organoids, there is no comprehensive review of various
methodologies specifically focusing on kidney organoids. This review summarizes the updated differentiation
methodologies, applications, and challenges associated with kidney organoids. Here
we have comprehensively collated all the different variables influencing the organoid generation.
Alcance de la S.A.S. en el derecho societario a la luz del principio de la libertad contractual
Authors: Ortiz Cano María Isabel 
Published: August 2021

This article analyzes the legal incentives and obstacles included in the Law 1258/2008 which regulates the Simplified Joint Stock Company type in the colombian legal system. Given the fact that there are a lot of subsidiary rules and very few imperative rules in this Law, allowing the shareholders to create their own rules. For this reason the text contrasts the Simplified Joint Stock Company regulation with the rules of other companies typified in the Colombian Commercial Code, regarding the principle of contractual freedom and its historical development in the corporate law. Furthermore, the text measures the overall scope of the Simplified Joint Stock Company type in the colombian legal system within more than a decade of its existence.
Effectiveness of Text Messaging Interventions on Blood Pressure Control Among Patients With Hypertension: Systematic Review of Randomized Controlled Trials
Authors: Tam Hon Lon , Wong Eliza Mi Ling , Cheung Kin , Chung Siu Fung 
Published: August 2021

Background
Controlling blood pressure (BP) is an international health concern, and high BP is a major contributor to cardiovascular disease mortality. Evidence has shown that educational interventions directed at patients potentially improve BP control and adherence to medications and lifestyle modifications. In addition, a text messaging intervention has a potential effect on BP control; however, the dosage of a text messaging intervention has not been determined in previous reviews, resulting in difficult application in practice.

Objective
This review aimed to identify the effectiveness of a text messaging intervention on hypertension management with a specific focus on the dosage of text messaging and the type of additional interventions with text messaging.

Methods
A systematic review was conducted and reported on in accordance with PRISMA guideline. Participants were aged 18 years and older and diagnosed with primary hypertension. The included studies used text messaging as a component of the intervention. We searched for randomized controlled trials published until June 30, 2020, from the following health-related electronic databases: Embase, Medline, CINAHL Complete, PsycINFO, and Scopus. Data were extracted for qualitative synthesis and meta-analysis. The Physiotherapy Evidence Database Scale was used to assess the methodological quality of each study, and the quality of the included studies was assessed independently by two authors.

Results
Twelve studies met the inclusion criteria. The overall methodological quality was fair (mean score 5.75). The frequency of text message delivery varied from daily to biweekly. Health education was identified in 4 studies as an additional intervention with text messaging. The overall results showed that the text messaging intervention significantly reduced systolic BP (SBP) but not diastolic BP (DBP). There was no significant difference in BP reduction between studies that lasted 6 months or less and those that lasted more than 7 months. Seven studies that lasted 6 months or less involving 1428 patients with hypertension were pooled for further meta-analysis. Text messages delivered at a lower frequency (once per week or less) had a small effect on SBP reduction (effect size 0.35, P<.01) and DBP reduction (effect size 0.28, P=.01). In addition, the use of a text messaging intervention halved the odds of uncontrolled BP among patients with hypertension in 6 months (odds ratio 0.46, P=.02).

Conclusions
This review found that a text messaging intervention was effective in BP control. One-way text messaging delivered in a weekly manner was suggested to be effective and required fewer resources. Future studies should use different forms of text message and be integrated into other interventions to improve adherence behaviors and BP control among patients with hypertension.
Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review
Authors: Lang Michael , Lemieux Sébastien , Hébert Josée , Sauvageau Guy , Zawati Ma'n H 
Published: August 2021

Background
This study aims to identify a novel potential use for web portals in health care and health research: their adoption for the purposes of rapidly sharing health research findings with clinicians, scientists, and patients. In the era of precision medicine and learning health systems, the translation of research findings into targeted therapies depends on the availability of big data and emerging research results. Web portals may work to promote the availability of novel research, working in tandem with traditional scientific publications and conference proceedings.

Objective
This study aims to assess the potential use of web portals, which facilitate the sharing of health research findings among researchers, clinicians, patients, and the public. It also summarizes the potential legal, ethical, and policy implications associated with such tools for public use and in the management of patient care for complex diseases.

Methods
This study broadly adopts the methods for scoping literature reviews outlined by Arskey and O’Malley in 2005. Raised by the integration of web portals into patient care for complex diseases, we systematically searched 3 databases, PubMed, Scopus, and WestLaw Next, for sources describing web portals for sharing health research findings among clinicians, researchers, and patients and their associated legal, ethical, and policy challenges. Of the 719 candidate source citations, 22 were retained for the review.

Results
We found varied and inconsistent treatment of web portals for sharing health research findings among clinicians, researchers, and patients. Although the literature supports the view that portals of this kind are potentially highly promising, they remain novel and are not yet widely adopted. We also found a wide range of discussions on the legal, ethical, and policy issues related to the use of web portals to share research data.

Conclusions
We identified 5 important legal and ethical challenges: privacy and confidentiality, patient health literacy, equity, training, and decision-making. We contend that each of these has meaningful implications for the increased integration of web portals into clinical care.
Pandemia de COVID-19 y abstencionismo en las elecciones municipales del estado de Hidalgo
Authors: Lizama Carrasco Guillermo 
Published: August 2021

En este artículo se explora la relación entre el abstencionismo electoral y la pandemia de covid-19 en las elecciones municipales del estado de Hidalgo en 2020. Para ello, se plantea como pregunta: ¿el riesgo colectivo producto de la pandemia de covid-19 provocó una menor participación electoral? La interrogante se debe a que las tasas de contagiados y de fallecimientos por el virus SARS-CoV-2 generan riesgo en la sociedad y, por ende, altos costos para los electores. Para responder a esta pregunta, se emplea una metodología cuantitativa a través de medidas de asociación entre variables (prueba t de Student, correlación de Pearson y coeficiente de determinación). Los resultados se analizan desde el enfoque sociológico del comportamiento electoral e indican preliminarmente que no existe una relación estadística significativa entre la pandemia y la participación; tampoco se observan diferencias importantes en las tasas de abstencionismo comparadas con aquellas de la elección municipal de 2016.
UM BREVE ESTUDO SOBRE AS MINISSÉRIES BRASILEIRAS
Authors: Alcantara Lídia 
Published: August 2021

Este artigo tem como principal objeto de estudo as minisséries brasileiras. Para isso, buscamos defini-las e caracteriza-las, exemplificando-as e comparando-as com outros modos de narrar da teleficção seriada brasileira, como as telenovelas e seriados por exemplo. Procuramos traçar um breve percurso das minisséries ao longo dos anos na televisão brasileira, identificando o que as diferencia das telenovelas, principalmente, bem como sua quantidade de episódios, suas principais tramas, suas principais características etc. Para tanto, utilizaremos as definições de autores como Balogh, Pallotini e Orofino, e também falaremos um pouco sobre o folhetim, pois foi daí que surgiu o modo de narrar de forma seriada.
Bimbingan Teknis Aplikasi Portal Rumah Belajar pada Praktik Pembelajaran Daring di Masa Pandemi Covid-19
Authors: Lathifah Zahra Khusnul , Utami Irma Inesia Sri 
Published: August 2021

Portal Rumah Belajar merupakan aplikasi berbasis internet yang diluncurkan oleh Kemdikbud untuk memfasilitasi terciptanya ruang kelas maya pada praktik pengajaran dalam jaringan (daring). Penggunaan aplikasi tersebut sesungguhnya relevan dengan pembelajaran di masa pandemi yang menerapkan sistem Pembelajaran Jarak Jauh (PJJ). Berkaitan dengan hal tersebut aplikasi Portal Rumah Belajar menjadi salah satu aplikasi yang direkomendasikan oleh Kemdikbud pada para guru dalam melaksanakan kegiatan belajar mengajarnya di masa pandemi. Namun fakta di lapangan menunjukkan bahwa pemanfaatan Portal Rumah Belajar terbilang masih rendah bila dibandingkan dengan penggunaan WhatsApp Group. Penggunaan WhatsApp Group sebagai sarana pembelajaran daring sesungguhnya memiliki keterbatasan dalam memfasilitasi ruang kelas online yang aktif sehingga kegiatan pembelajaran cenderung monoton. Selain itu, pengelolaan pembelajaran pun sulit dilakukan oleh guru. Analisis situasi terhadap permasalahan tersebut melatarbelakangi pelaksanaan kegiatan pengabdian berupa bimbingan teknis aplikasi Portal Rumah Belajar dalam pembelajaran daring di masa pandemi. Berdasarkan hal tersebut, adanya kegiatan pengabdian ini bertujuan untuk memfasilitasi para guru agar dapat memahami, mempraktikkan dan mampu mengoptimalkan kegiatan pembelajaran daring di masa pandemi melalui pemanfaatan aplikasi Portal Rumah Belajar. Metode kegiatan pengabdian dilaksanakan dalam bentuk kegiatan Webinar Nasional dalam tiga sesi kegiatan. Terkait dengan capaian dan keberhasilan tiap sesi digunakan teknik post tes guna mengetahui bagaimana capaian dan keberhasilan peserta pada tiap sesi webinar. Hasil pelaksanaan kegiatan pengabdian ini menunjukkan bahwa para peserta yakni guru dari berbagai wilayah di Indonesia diantaranya Jawa Barat, Belitung, dan Jawa Tengah memperoleh pemahaman baik berupa teori maupun praktik mengenai pemanfaatan aplikasi Portal Rumah Belajar beserta fitur utama maupun fitur pendukung untuk menunjang optimalisasi kegiatan pembelajaran dengan sistem daring di masa pandemi. Secara umum dapat disimpulkan bahwa pelaksanaan kegiatan pendampingan ini mampu meningkatkan pemahaman dan antusiasme para guru peserta kegiatan Webinar Nasional untuk melaksanakan pembelajaran daring yang berkualitas di satuan pendidikan masing-masing.