bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lamotrigine and Lithium Combination for Treatment of Rapid Cycling Bipolar Disorder: Results From Meta-analysis
Authors: Gao Zhihan , Sun Fengli , Lv Wangqiang , Shen Dong , Jin Weidong 
Published: August 2021

Abstract
Objective: to observe effect of combination of lithium and lamotrigine in treatment for Rapid-cycling bipolar disorder(RCBD). Method: We searched both MEDLINE, EMBASE, Cochrane Library in English and CBM, CNKI, WANFANG and CSSCI in Chinese to find literature from January 1 2000 to December 31, 2020 related to combination of lithium carbonate and lamotrigine for treatment of RCBD.Results: Five comparison studies, with 265 subjects of 131 cases in study group and 134 cases in control group met the inclusion criteria and were included for the final meta-analysis. The comprehensive analysis show that study group had significant lower score of mental symptoms than that of control group (Z=2.34, P=0.02) by random model (X2=33.02, df=7, P<0.01).But these differences only were shown in PANSS (Z=5.18, P<0.01) and BPRS (Z=3.08, P<0.01).The no difference in response rate (54.9% vs 45.7%OR=1.47, 95% CI: 0.79~2.73, Z=1.21, P> 0.05,) and remission rate (47.9% vs 45.9%OR=1.05, 95% CI: 0.49~2.25, Z=0.13, P> 0.05,) were found between two groups. The response rate of lamotrigine and lithium combination was significant higher compare to monotherapy of lithium in patients with no treatment-resistant (82% V 54%, OR=4.26,95% CI: 1.65~10.99, Z=3.99, P< 0.01) by fixed effect model (X2=0.89, df=1, P>0.05, I2 =0%).Conclusion: Combination of lithium and lamotrigine have better improvement of psychotic symptoms and higher response rate in patients of RCBP with no treatment-resistant.
Secreted Indicators of Androgen Receptor Activity in Breast Cancer Pre-Clinical Models.
Authors: Hanamura Toru , Christenson Jessica L , O’Neil Kathleen I , Rosas Emmanuel , Spoelstra Nicole S , Williams Michelle M , Richer Jennifer K 
Published: August 2021

Abstract
Purpose. Accumulating evidence has attracted attention to the androgen receptor (AR) as a biomarker and therapeutic target in breast cancer. We hypothesized that AR activity within the tumor has clinical implications and investigated whether androgen responsive serum factors might serve as a minimally invasive indicator of tumor AR activity. Methods. Based on a comprehensive gene expression analysis of an AR-positive breast cancer patient-derived xenograft (PDX) model, 163 dihydrotestosterone (DHT)-responsive genes were defined as an androgen responsive gene set. Among them, we focused on genes that were DHT-responsive that encode secreted proteins, namely KLK3, AZGP1 and PIP, that encode the secreted factors prostate specific antigen (PSA), zinc-alpha-2-glycoprotein (ZAG) and prolactin induced protein (PIP), respectively. Using AR-positive breast cancer cell lines, expression of candidate factors was assessed in response to agonist DHT and antagonist enzalutamide. Gene set enrichment analysis (GSEA) was performed on publically available gene expression datasets from breast cancer patients to analyze the relationship between genes encoding the secreted factors and other androgen responsive gene sets. Results. Anti-androgen treatment decreased proliferation in all cell lines tested representing various tumor subtypes. Expression of the secreted factors was regulated by AR activation in the majority of breast cancer cell lines. In GSEA, the candidate genes were positively correlated with an androgen responsive gene set across breast cancer subtypes. Conclusion. KLK3, AZGP1 and PIP are AR regulated and reflect tumor AR activity. Further investigations are needed to examine the potential efficacy of these factors as serum biomarkers.
Inhibition of JAK3/STAT3 Activation in Rats Uterine Leiomyoma by formula of Taohong Siwu Decoction: A Randomized Controlled Trial
Authors: Luo Li , Shi Shasha , Zhang Li , Xu Xun , Peng Fu , Yu Chenghao , Li Liangwwen , Zheng Tie 
Published: August 2021

Abstract
Background: Traditional Chinese medicine (TCM) formula of Taohong Siwu decoction (THSW) is often used in traditional Chinese medicine for the treatment of uterine leiomyoma (UL). The effectiveness of THSW for the treatment of UL has been confirmed in previous studies. At present, there are few relevant mechanism studies. The purpose of this study is to explore the efficacy and mechanism of THSW in the treatment of uterine leiomyoma. Methods: A Sprague Dawley (SD) rat model of UL was established via estrogen and progesterone load combined with external stimulation for 5 weeks. We randomly assigned adult female non-pregnant rats into six groups: a control group, a UL model group, and a positive drug group, THSW(18g/ml) group, THSW(9g/ml) group, THSW(4.5g/ml) group. THSW group and positive drug group were treated with THSW medicinal solutions and gongliuxiao capsule medicinal solutions respectively after daily modeling for 3 weeks. Histological analyses, Polymerase Chain Reaction and western blotting were performed to evaluate the effect of THSW on UL and elucidate its mechanism of action. Results: The uterus morphology of the model group showed significantly more swelling than that of the control group, and pathological of changes of rats were obvious in the model group. Compared with model group, the pathological changes of UL were relieved in the THSW group. Our data showed that the treatment of rats with THSW significantly reduced the expression of cytotoxic T lymphocyte associated antign 4 (CTLA4) and indoleamine 2, 3-dioxygenase 1 (INDO). The phosphorylation of JAK3 and STAT3 which are the main signal transduction molecule of cytokines and growth factorswere were also inhibited. Conclusions: Our results suggest that THSW is effective in the prevention and treatment of UL in rats, and THSW may exert its functions by inhibiting the activation of Tumor-related signal transduction pathway (JAK3/STAT3), immune escape, proliferation of tumor cell and improving apoptosis.
The Effect of Exercise Intensity and Duration on Oxidative Stress and Antioxidant Enzymes Activity among Sedentary Healthy Adults: A Repeated Measures Study
Authors: Ag.Daud D.Maryama , Ahmedy Fatimah , Baharuddin Dg. Marshitah Pg. , Kamalden Tengku Fadilah Tengku , Ngah Wan Zurinah Wan 
Published: August 2021

Abstract
Background Aerobic exercise can increase oxidative stress, but it can produce the necessary stimulus for physiological adaptation of exercise. However, the effects of intensity and duration of exercise on oxidative stress status are unclear. This study aimed to compare the effects of exercise intensity (I) and duration (D) on the oxidative stress [malondialdehyde (MDA)], and the responses of the antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), antioxidant enzymes ratio (AE)] among sedentary adults. Methods In a randomized crossover design, 25 sedentary adults, performed nine cycling exercise sessions with a constant load of 50%, 60% and 70% VO2peak for 10-, 20- and 30- minutes duration. Plasma MDA, CAT, GPx and SOD activity were measured before exercise (baseline) and immediately after each session (post). Results The interaction effect of intensity and duration was significant for percentage changes of MDA (FIxD=3.59, df=4, p<0.05) and CAT activity (FIxD =3.38, df=2.146, p<0.05). Repeated Measures ANOVA analysis revealed that intensity is the major controlling factor for MDA (FI =54.24, df=2, p<0.05 vs FD=8.62, df=2, p<0.05), and CAT responses (FI =14.24, df=1.619, p<0.05 vs FD = 5.96, df=1.347, p<0.05). However, the main determinant factor for SOD (FD =11.82, df=1.166, p<0.05 vs FI =5.58, df=1.289, p<0.05) and AE (FD =11.63, df=1.201, p<0.05 vs. FI =3.035, df=1.32, p>0.05) is exercise duration. Conclusions These findings suggest that exercise intensity was an essential factor of acute oxidative stress and antioxidant enzyme responses compared with the duration of exercise.
Determination of Pesticides Residue by GC-ECD in Vegetables from Cameron Highlands, Malaysia and Their Human Health Risk Assessment
Authors: Munawar Nusrat , Sherino Bibi , Afzal Saba , Yaqoob Mohammad , Nabi Abdul 
Published: August 2021

Abstract
Gas chromatography-electron capture detection (GC-ECD) method has been developed to determine the residues of pyrethroid (PYRs), organophosphorus (OPPs) and organochlorine (OCPs) pesticide in 97 leafy vegetable samples collected from Cameron Highlands, Malaysia. The mean residual concentration of PYRs, OPPs and OCPs ranged from 0.04–17, 0.03–44.4 and 0.03–100 μg kg–1 respectively. The sum of pesticides concentration increased in the order mustard < spinach < celery < cauliflower < lettuce < broccoli < cabbage. The results revealed that levels of maximum residue limit (MRL) for OCPs were violated by lettuce (7.7%), for OPPs, it exceeded mostly in cabbage (24.8%) and for PYRs only one cabbage sample exceeded the MRL. Health risk estimation revealed that hazard quotients (HQs) for OCPs, OPPs and PYRs were <1.0, showing less risk to consumers. However, the hazard indices (HIs) for OPPs were >1.0 for children (1.4) and for adults (0.4) which signify the potential health risk to consumers.
Assessing the Credibility of Best Suited Communication Channels in Rural Communities for Meeting the Unmet Need Towards Reducing Child and Adolescent Marriage: a Model From Upper Egypt
Authors: Metwally Ammal M. , Abuelela Manal H. , Elmosalami Dalia M. , Mohsen Amira , Amer Hala A. , Eldeeb Sherif M. , Etreby Lobna A. El , Abdel-Latif Ghada A. , El-Sonbaty Marwa M. , Hasanin Hasanin M. , Mawla Mohamed A. Abdel , Hasan Hatem Mohamed , Salama Sameh , Salem Sondos , Ibrahim Nihad A. , Emam Hanaa , Abdelmohsen Aida M. , Fouad Walaa A. , Salama Somia I. , Salama Iman I. , Saleh Rehan M. 
Published: August 2021

Abstract
Background: Low levels of scholarly achievement, poverty, and geographical isolation are all known to be linked to early marriage. This study aimed at identifying the most credible and the best-suited communication channels (CCs) to reach rural communities for motivating them to reduce child and adolescent marriage. Methods: A cross-sectional study targeted 1000 wives and their husbands were conducted in 21 rural village units of two governorates of Upper Egypt through questionnaires. Decisions concerning the choice of the best-suited communication channels were based on their Reach; Frequency; Managerial feasibility and Effectiveness. Results: a vast majority of the surveyed wives (96.6%) were married at an age ranging from 15-24 years. The spread of social media through smartphones was limited to only one-third of wives and their husbands through mainly searching on YouTube (31.7% of wives and 27.8% of husbands). Television was the most accessible means of mass media for both wives and husbands (72.5% and 63.3% respectively). The most credible and the best-suited CCs methods for wives were talking with the health promotors and doctors with two times significantly higher (OR= 2.0) than that with the search on YouTube and three times significantly higher (OR = 3.1) than that for social media using browser engine. For husbands, the odds were 1.6 for all. Conclusions: Despite the availability of recent social media worldwide, rural communities; with high illiteracy, limited access to the internet, and limited availability of smartphones. Interpersonal communication is considered the most effective CCs for achieving equity in reducing child marriage. It seems vital during the implementation of any strategies towards reproductive health to use not only the media broadcasts but also to rely on the channels that are most credible and suitable for the targeted communication to support meeting the unmet need.
Whole-cell catalysis by surface display of fluorinase on Escherichia coli using N-terminal domain of ice nucleation protein
Authors: Feng Xinming , Jin Miaomiao , Huang Wei , Liu Wei , Xian Mo 
Published: August 2021

Abstract
BackgroundFluorinases play a unique role in producing fluorinated organic molecules through a biological method. Whole-cell catalysis is a better choice in the large-scale fermentation processes, and over 60% of industrial biocatalysis uses this method. However, the in vivo catalytic efficiency of fluorinases is stuck with the mass transfer of the substrates.ResultsA gene sequence encoding a protein with fluorinase function was fused to the N-terminal of ice nucleation protein, and the fused protein was expressed in Escherichia coli BL21(DE3) cells. SDS-PAGE and Immunofluorescence microscopy were used to demonstrate the surface localization of the fusion protein. The fluorinase-containing surface display system with improved whole-cell catalytic efficiency and stability showed low growth pressure on the protein expressing host. The conversion rate of 5′-fluorodeoxyadenosine (5′-FDA) from S-adenosyl-L-methionine (SAM) achieved 55%.ConclusionsHere, we created the fluorinase-containing surface display system on E.coli cells for the first time. The fluorinase was successfully displayed on the surface of Escherichia coli and maintained its catalytic activity. The surface display offers a new solution for the industrial application of biological fluorination.
Machine Learning for the Prediction of Springback in High Tensile Strength Steels after V-Bending Process Using Tree-Based Learning
Authors: Baig Saad Ur Rehman , Wasif Muhammad , Fatima Anis , Baig Mirza Muhammad Anas , Iqbal Syed Amir 
Published: August 2021

Abstract
Sheet metal bending is a typical operation and springback is an unintended consequence of this operation. Since it causes fitting issues in the assembly, which leads to quality problems, anticipating it long before the bending operation is done is essential in today's production, so that machining parameters can be adjusted accordingly. In order to predict springback with minimum errors, this paper presents the idea for the development of machine learning models using tree-based learning algorithms (A class of machine learning algorithms). Tree-based learning algorithms are employed because they are precise, consistent, and easy to understand. Experimental studies provided the data for training and testing the models. The model's input parameters were sheet Material, Thickness, Width, Initial Angle (Desired angle), and Machine used to perform the bending. Following the training and testing of different tree-based learning algorithms, the results were evaluated using MAE and MSE. It was determined that Gradient boosting algorithms (a class of tree-based learning) gave the best results. Later on further evaluation of algorithms, it was found that LightGBM produced the best results, with MAE and MSE of 0.41 and 0.25, respectively.
Under-five Mortality and Associated Factors among Children Born from 15-49 Years Old Mothers in Haramaya Town, Eastern Ethiopia
Authors: Ahmed Mohammed , Demena Melake , Teklemariam Zelalem 
Published: August 2021

Abstract
Background: The global under-five mortality rate has dropped from almost 90 deaths per 1,000 live births in 1990 to 43 in 2015. The Ethiopian Mini Demographic Health Survey, 2019 shows 55 under-five deaths per 1,000 live births. In the eastern part of Ethiopia, evidence from the Kersa Health and Demographic Surveillance System in Kersa district of East Hararghe Zone, Oromia Region suggested the decline of under-five mortality rate from 131.8 per 1000 live births in 2008 to 77.4 per 1000 live births in 2013. The death rates still remain far from the Sustainable Development Goals’ target reduction to 25 or less per 1000 live births by 2030. However, the magnitude and determinants of under-five mortality is not studied in Haramaya town. Objective: To assess the under-five mortality rate and associated factors among children born during August 07, 2015- August 06, 2020 in Haramaya town, east Ethiopia by August 07–31/2020. Methodology: Quantitative cross-sectional population-based study was conducted on 391 pairs of 15-49 years old mothers and their live-born under-five children selected using systematic random sampling technique from Haramaya town to cmpare mortality between <=24 and >=25 mother’s age groups. Data were collected using interview-based questionnaire; double entered into EpiData 3.1; and then exported to statistical package for social sciences program version 20.0 for analysis. Binary logistic regression analysis (p-value <0.20) was performed to examine crude association of predictors with under-five mortality, and then multiple logistic regression analysis (p-value <0.05) to measure the statistical association. Results: The death of 28 out of 372 live births gave an under-five mortality rate of 75 per 1000 live births. Children born in households with less than 6 members had 7. 98 times higher odds of dying than those born in households with at least 6 members (AOR =7.98, 95% CI =1.59-40.17). Those children who did not feed colostrum were associated with 17.45 times increased risk of under-five deaths compared to colostrum-fed ones (AOR =17.45, 95% CI =6.54-46.55). Conclusion: The study suggests that 75 per 1000 live births die before celebrating their fifth birth day. Household size and colostrum feeding are the significantly associated factors.Recommendation: All concerned should inform the mothers the role of identified factors like household size and colostrum feeding in child survival.
Análisis de tendencias de investigación en comunicación política en los nuevos contextos globales
Authors: Huerta Vilchis Fernando 
Published: August 2021

El primer número de la Revista Panamericana de Comunicación, correspondiente al año 1, número 1, enero-diciembre de 2019, está dedicado al tema monográfico de la comunicación política. El hecho no es casual porque el Consejo editorial de la misma ha coincidido en el tema dado el gran acontecimiento en la vida política y social mexicana constituido por las elecciones generales de 2018 donde fue elegido un nuevo presidente para nuestro país. Hemos incorporado nueve artículos redactados por importantes y esclarecidos investigadores de México y España, primicia de los argumentos que pretenden apuntalar a esta publicación como referencia de futuro.
A new Xin'anjiang and Sacramento combined rainfall-runoff model and its application
Authors: Zhang Maolin , Wang Jinwen , Huang Yanxuan , Yu Lili , Liu Shuangquan , Ma Gaoquan 
Published: August 2021

Abstract
The Xin'anjiang model and the Sacramento model are two widely used short-term watershed rainfall-runoff forecasting models, each with their own unique model structure, strengths, weaknesses and applicability. This paper introduces a weight factor to integrate the two models into a combined model, and uses the cyclic coordinate method to calibrate the weight factor and the parameters of the two models to explore the possibility of the complementarity between the two models. With application to the Yuxiakou watershed in Qingjiang River, it is verified that the cyclic coordinate method, although simple, can converge rapidly to a satisfactory calibration accuracy, mostly after two iterations. Also, the results in case studies show that the forecast accuracy of the new combined rainfall-runoff model can improve the forecast precision by 4.3% in a testing period, better in runoff process fitting than the Xin'anjiang model that performs better than the Sacramento model.
Adsorption of vanadium with amorphous hydrated chromium oxide
Authors: Li Hualin , Zhang Hongling , Luo Minting , Dong Yuming , Xu Hongbin , Cheng Xichuan , Cai Zaihua 
Published: August 2021

Abstract
Vanadium is recognized as a potentially dangerous pollutant following closely behind lead, mercury and arsenic. Vanadium removal from wastewater prior to discharge is essential. In this work, an amorphous hydrated chromium oxide was prepared and its vanadium adsorption ability studied. As prepared, the hydrated oxide showed high efficiency in vanadium adsorption – e.g., from 300 to 0.75 mg-V·L−1. The effects of pH, adsorbent dosage, temperature, adsorption time and the presence of other ions on the vanadium removal rate were investigated, and optimal parameters determined. Dynamic adsorption results showed that pseudo-second-order kinetics could be used to interpret the kinetic curve and that the process was that of chemisorption. The Langmuir isotherm was found to fit the adsorption behavior well.
Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer
Authors: Ozkan Erva , Bakar-Ates Filiz 
Published: August 2021

:
Ferroptosis, which is an iron-dependent, non-apoptotic cell death mechanism,
has recently been proposed as a novel approach in cancer treatment. Bearing distinctive
features and its exclusive mechanism have put forward the potential therapeutic benefit
of triggering this newly discovered form of cell death. Numerous studies have indicated
that apoptotic pathways are often deactivated in resistant cells, leading to a failure in therapy.
Hence, alternative strategies to promote cell death are required. Mounting evidence
suggests that drug-resistant cancer cells are particularly sensitive to ferroptosis. Given
that cancer cells consume a higher amount of iron than healthy ones, ferroptosis not only
stands as an excellent alternative to trigger cell death and reverse drug-resistance, but also
provides selectivity in therapy. This review focuses specifically on overcoming drugresistance
in cancer through activating ferroptotic pathways and brings together the relevant
chemotherapeutics-based and nanotherapeutics-based studies to offer a perspective
for researchers regarding the potential use of this mechanism in developing novel therapeutic
strategies.
Cancer Risk and Nullity of Glutathione-S-Transferase Mu and Theta 1 in Occupational Pesticide Workers
Authors: Usman Muhammad Bello , Priya Kanu , Pandit Soumya , Gupta Piyush Kumar 
Published: August 2021

:
Occupational exposure to pesticides has been associated with adverse health conditions, including genotoxicity and cancer. Nullity of GSTT1/GSTM1 increases the susceptibility of pesticide workers to these adverse health effects due to lack of efficient detoxification process created by the absence of these key xenobiotic metabolizing enzymes. However, this assertion does not seem to maintain its stance at all the time; some pesticide workers with the null genotypes do not present the susceptibility. This suggests the modulatory role of other confounding factors, genetic and environmental conditions. Pesticides, aggravated by the null GSTT1/GSTM1, cause genotoxicity and cancer through oxidative stress and miRNA dysregulation. Thus, the absence of these adverse health effects together with the presence of null GSTT1/GSTM1 genotypes demands further explanation. Also, understanding the mechanism behind the protection of cells – that are devoid of GSTT1/GSTM1 – from oxidative stress constitutes a great challenge and potential research area. Therefore, this review article highlights the recent advancements in the presence and absence of cancer risk in occupational pesticide workers with GSTT1 and GSTM1 null genotypes.
Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti-Cancer Drug Target
Authors: Kambaru Archanalakshmi , Chaudhary Nidhee 
Published: August 2021

:
Protein Tyrosine Phosphatase (PTP) superfamily is a key enzyme involved in the regulation of growth-related cell signaling cascades, such as the RAS/MAPK pathway, that directly affect cancer cell growth and metastasis. Several studies have indicated that the drug resistance observed in several late-stage tumors might also be affected by the levels of PTP in the cell. Hence, these phosphatases have been in the limelight for the past few decades as potential drug targets and several promising drug candidates have been developed, even though none of these drugs have reached the market yet. In this review, we explore the potential of PTP as a viable anti-cancer drug target by studying PTPs, their regulation of several key cancer cell signaling pathways, and how their levels affect various types of cancer. Furthermore, we present the current scenario of PTP as a molecular target and the various challenges faced in the development of PTP-targeting anti-cancer drugs.