bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
Authors: Salinero-Fort M. A. , Andrés-Rebollo F. J. San , Cárdenas-Valladolid J. , Méndez-Bailón M. , Chico-Moraleja R. M. , de Santa Pau E. Carrillo , Jiménez-Trujillo I. , Gómez-Campelo I. , de Burgos Lunar C. , de Miguel-Yanes J. M. ,   MADIABETES, Abanades-Herranz J. C. , Vicente-Tutor A. M. Sobrado-de , Sanz-Pascual Mar , Arnalte-Barrera M. , Pulido-Fernández S. , Donaire-Jiménez E. M. , Montero-Lizana C. , Domínguez-Paniagua M. , Serrano-Simarro P. , Echegoyen-de Nicolás R. , Gil-Díaz P. , Cerrada-Somolinos I. , Martín-Cano R. , Cava-Rosado A. , Mesonero-Grandes T. , Gómez-Navarro E. , Maestro-Martín A. , Muñoz-Cildoz A. , Calonge-García M. E. , Martín-Bun M. , Carreño-Freire P. , Fernández-García J. , Morán-Escudero A. , Martínez-Irazusta J. , Calvo-García E. , Alayeto-Sánchez A. M. , Reyes-Madridejos C. , Bedoya-Frutos M. J. , López-Sabater B. , Innerarity-Martínez J. , Rosillo-González A. , Menéndez-Fernández A. I. , Mata-Benjumea F. , Vich-Pérez P. , Martín-Madrazo C. , Gomara-Martínez M. J. , Bello-González C. , Pinilla-Carrasco A. , Camarero-Shelly M. , Cano-Espin A. , Castro Martin J. , de Llama-Arauz B. , de Miguel-Ballano A. , García-Alonso M. A. , García-Pascual J. N. , González-García M. I. , López-Rodríguez C. , Miguel-Garzón M. , Montero-García M. C. , Muñoz-Quiros-Aliaga S. , Núñez-Palomo S. , Olmos-Carrasco O. , Pertierra-Galindo N. , Reviriego-Jaén G. , Rius-Fortea P. , Rodríguez-Castro G. , San Vicente-Rodríguez J. M. , Serrano-Serrano M. E. , Zamora-Gómez M. M. , Zazo-Lázaro M. P. 
Published: July 2021

AbstractWe aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90–1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65–85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88–6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).
Population consequences of climate change through effects on functional traits of lentic brown trout in the sub-Arctic
Authors: Bærum Kim Magnus , Finstad Anders G. , Ulvan Eva Marita , Haugen Thrond O. 
Published: July 2021

AbstractClimate-induced plasticity in functional traits has received recent attention due to the immense importance phenotypic variation plays in population level responses. Here, we explore the effect of different climate-change scenarios on lentic populations of a freshwater ectotherm, the brown trout (Salmo trutta L.), through climate effects on functional traits. We first parameterize models of climate variables on growth, spawning probability and fecundity. The models are utilized to inform a dynamic age-structured projection matrix, enabling long-term population viability projections under climate and population density variation. Ambient temperature and winter conditions had a substantial effect on population growth rate. In general, warmer summer temperatures resulted in faster growth rates for young fish but ended in smaller size at age as fish got older. Increasing summer temperatures also induced maturation at younger age and smaller size. In addition, we found effects of first-year growth on later growth trajectories for a fish, indicating that environmental conditions experienced the first year will also influence size at age later in life. At the population level, increasing temperatures average (up to 4 °C increase in areas with mean summer temperature at approximately 12 °C) resulted in a positive effect on population growth rate (i.e. smaller but more fish) during climate simulations including increasing and more variable temperatures.
Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics
Authors: Sivapalan Rohan , Liu Jinyan , Chakraborty Krishnendu , Arthofer Elisa , Choudhry Modassir , Barie Philip S. , Barouch Dan H. , Henley Tom 
Published: July 2021

AbstractThe a priori T cell repertoire and immune response against SARS-CoV-2 viral antigens may explain the varying clinical course and prognosis of patients having a mild COVID-19 infection as opposed to those developing more fulminant multisystem organ failure and associated mortality. Using a novel SARS-Cov-2-specific artificial antigen presenting cell (aAPC), coupled with a rapid expansion protocol (REP) as practiced in tumor infiltrating lymphocytes (TIL) therapy, we generate an immune catalytic quantity of Virus Induced Lymphocytes (VIL). Using T cell receptor (TCR)-specific aAPCs carrying co-stimulatory molecules and major histocompatibility complex (MHC) class-I immunodominant SARS-CoV-2 peptide-pentamer complexes, we expand virus-specific VIL derived from peripheral blood mononuclear cells (PBMC) of convalescent COVID-19 patients up to 1000-fold. This is achieved in a clinically relevant 7-day vein-to-vein time-course as a potential adoptive cell therapy (ACT) for COVID-19. We also evaluate this approach for other viral pathogens using Cytomegalovirus (CMV)-specific VIL from donors as a control. Rapidly expanded VIL are enriched in virus antigen-specificity and show an activated, polyfunctional cytokine profile and T effector memory phenotype which may contribute to a robust immune response. Virus-specific T cells can also be delivered allogeneically via MHC-typing and patient human leukocyte antigen (HLA)-matching to provide pragmatic treatment in a large-scale therapeutic setting. These data suggest that VIL may represent a novel therapeutic option that warrants further clinical investigation in the armamentarium against COVID-19 and other possible future pandemics.
Passive repetitive stretching is associated with greater muscle mass and cross-sectional area in the sarcopenic muscle
Authors: Wang Yumin , Ikeda Satoshi , Ikoma Katsunori 
Published: July 2021

AbstractMechanical stimulation has benefits for muscle mass and function. Passive stretching is widely performed in clinical rehabilitation medicine. However, the hypertrophic effects of passive repetitive stretching on senescent skeletal muscles against muscle atrophy remain unknown. We used senescence-accelerated model SAM-P8 mice. The gastrocnemius muscle was passively repetitive stretched by manual ankle dorsiflexion for 15 min, 5 days a week for 2 weeks under deep anesthesia. We examined the effects of passive stretching on muscle mass, myofiber cross-sectional area, muscle fiber type composition, satellite cell and myonuclei content, signaling pathways involved in muscle protein synthesis, and myogenic regulatory factors. The gastrocnemius muscle weight and fiber cross-sectional area of the stretched side was found greater compared with that of the unstretched side. Passive repetitive stretching increased the mRNA expression level of Akt, p70S6K, 4E-BP1, Myf5, myogenin, MuRF1.The phosphorylation level of p70S6K significantly increased in the stretched muscles, whereas of Akt and 4E-BP1 remained unchanged, compared to the unstretched side. The Pax7+ cells and myonuclei content did not differ between the stretched and unstretched muscles. These findings suggest that the hypertrophic or suppressed atrophic observation in the stretched muscles are mainly attributable to the protein turnover provoked by stretching. These findings are applicable to clinical muscle strengthening and sarcopenia prevention.
The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
Authors: Matsumoto Takahiro , Hoshi Hideyuki , Hirata Yoko , Ichikawa Sayuri , Fukasawa Keisuke , Gonda Tomoyuki , Poza Jesús , Rodríguez-González Víctor , Gómez Carlos , Shigihara Yoshihito 
Published: July 2021

AbstractCerebral hypoperfusion impairs brain activity and leads to cognitive impairment. Left and right common carotid arteries (CCA) are the major source of cerebral blood supply. It remains unclear whether blood flow in both CCA contributes equally to brain activity. Here, CCA blood flow was evaluated using ultrasonography in 23 patients with cerebrovascular diseases. Resting-state brain activity and cognitive status were also assessed using magnetoencephalography and a cognitive subscale of the Functional Independence Measure, respectively, to explore the relationships between blood flow, functional brain activity, and cognitive status. Our findings indicated that there was an association between blood flow and resting-state brain activity, and between resting-state brain activity and cognitive status. However, blood flow was not significantly associated with cognitive status directly. Furthermore, blood velocity in the right CCA correlated with resting-state brain activity, but not with the resistance index. In contrast, the resistance index in the left CCA correlated with resting-state brain activity, but not with blood velocity. Our findings suggest that hypoperfusion is important in the right CCA, whereas cerebral microcirculation is important in the left CCA for brain activity. Hence, this asymmetry should be considered when designing appropriate therapeutic strategies.
Evolution of a neuromuscular sexual dimorphism in the Drosophila montium species group
Authors: Liang Han-qing , Katoh Toru , Sato Kosei , Yamamoto Daisuke , Wen Shuo-yang 
Published: July 2021

AbstractWhile epigamic traits likely evolve via sexual selection, the mechanism whereby internal sexual dimorphism arises remains less well understood. Seeking clues as to how the internal sexual dimorphism evolved, we compared the abdominal musculature of 41 Drosophila montium group species, to determine whether any of these species carry a male-specific muscle of Lawrence (MOL). Our quantitative analysis revealed that the size of a sexually dimorphic MOL analog found in 19 montium group species varied widely from species to species, suggesting the gradual evolution of this sexually dimorphic neuromuscular trait. We attempted the ancestral state reconstitution for the presence or absence of the neuromuscular sexual dimorphism in the A5 segment; the neuromuscular sexual dimorphism existed in an old ancestor of the montium group, which was lost in some of the most recent common ancestors of derived lineages, and subsequently some species regained it. This loss-and-gain history was not shared by evolutionary changes in the courtship song pattern, even though both traits were commonly regulated by the master regulator male-determinant protein FruM. It is envisaged that different sets of FruM target genes may serve for shaping the song and MOL characteristics, respectively, and, as a consequence, each phenotypic trait underwent a distinct evolutionary path.
An octa-band planar monopole antenna for portable communication devices
Authors: Azim Rezaul , Alam Touhidul , Mia Md Sharif , Almutairi Ali F. , Islam Mohammad Tariqul 
Published: July 2021

AbstractDue to the rapid development of wireless communication systems, good numbers of services and devices use different frequency bands and protocols. To concurrently cover all these services, the antenna in communication devices should operate over multiple frequency bands. The use of wide and multi-band antennas not only reduces the number of antennas necessary to cover multiple frequency bands but also lessens the system complexity, size, and costs. To operate over eight frequency bands to cover sixteen well-established narrow service bands, a planar monopole antenna is proposed for portable communication devices. The proposed antenna is comprised of an inverted F-shaped monopole patch with a rotated L-shaped strip and an F-shaped ground strip with a rotated L-shaped branch. The studied antenna can excite at multiple resonant modes which helps it to achieve eight measured operating bands of 789–921 MHz, 1367–1651 MHz, 1995–2360 MHz, 2968–3374 MHz, 3546–3707, 4091–4405 MHz, 4519–5062 MHz and 5355–6000 MHz. The achieved measured operating bands can cover sixteen popular narrow service bands for 4G/3G/2G, MWT, WiFi, WiMAX, WLAN, and sub-6 GHz 5G wireless communication system. The studied antenna achieved good gain, efficiency and exhibits stable radiation characteristics. Moreover, the antenna does not use any lumped element and left ample space for other circuitries which makes it easier to use in portable devices such as tablets, laptops, etc. with low manufacturing cost.
Rhizospheric Lactobacillus plantarum (Lactiplantibacillus plantarum) strains exhibit bile salt hydrolysis, hypocholestrolemic and probiotic capabilities in vitro
Authors: Singhal Neelja , Singh Nambram Somendro , Mohanty Shilpa , Kumar Manish , Virdi Jugsharan Singh 
Published: July 2021

AbstractLactobacillus plantarum (renamed as Lactiplantibacillus plantarum) has been isolated from many sources but very rarely from rhizospheric soil. This is the first report on isolation and assessment of probiotic capabilities of L. plantarum strains isolated from rhizospheric soil. The isolates were confirmed by 16S rRNA gene sequencing and named as NS14, NS16 and NGG. All the isolates were evaluated for bile salt hydrolysis, hypocholestrolemic potential and probiotic attributes. Our results indicated that all the strains harboured bsh and showed in vitro cholesterol assimilation capabilities which increased when bile salts were also present in the culture medium. Also, all the strains remained viable at high temperatures and in the presence of NaCl, lysozyme, simulated gastric juice, bile salts and, exhibited auto- and co-aggregation capabilities. Additionally, L. plantarum strain NS14 survived in the presence of phenols, acidic environment (pH 2–3) and was resistant to many clinically relevant antibiotics. Since, L. plantarum NS14 exhibited most of the desirable and essential characteristics of a probiotic it should be further investigated as a potent probiotic with an additional benefit as a hypocholesterolemic biotherapeutic. Moreover, rhizosphere can be explored as a useful ecological niche for isolating microorganisms with biotechnological and probiotic potential.
Mapping each pre-existing condition’s association to short-term and long-term COVID-19 complications
Authors: Venkatakrishnan A. J. , Pawlowski Colin , Zemmour David , Hughes Travis , Anand Akash , Berner Gabriela , Kayal Nikhil , Puranik Arjun , Conrad Ian , Bade Sairam , Barve Rakesh , Sinha Purushottam , O‘Horo John C. , Badley Andrew D. , Halamka John , Soundararajan Venky 
Published: July 2021

AbstractUnderstanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage ~1.1 million clinical notes from 1803 hospitalized COVID-19 patients and deep neural network models to characterize associations between 21 pre-existing conditions and the development of 20 complications (e.g. respiratory, cardiovascular, renal, and hematologic) of COVID-19 infection throughout the course of infection (i.e. 0–30 days, 31–60 days, and 61–90 days). Pleural effusion was the most frequent complication of early COVID-19 infection (89/1803 patients, 4.9%) followed by cardiac arrhythmia (45/1803 patients, 2.5%). Notably, hypertension was the most significant risk factor associated with 10 different complications including acute respiratory distress syndrome, cardiac arrhythmia, and anemia. The onset of new complications after 30 days is rare and most commonly involves pleural effusion (31–60 days: 11 patients, 61–90 days: 9 patients). Lastly, comparing the rates of complications with a propensity-matched COVID-negative hospitalized population confirmed the importance of hypertension as a risk factor for early-onset complications. Overall, the associations between pre-COVID conditions and COVID-associated complications presented here may form the basis for the development of risk assessment scores to guide clinical care pathways.
A Lacanian supplementation to love in L’Immanence des vérités
Authors: Youngjin Park 
Published: July 2021

AbstractIn L’Immanence des vérités, Alain Badiou rewrites the Platonic allegory of the cave. As the book’s structure reveals, Badiou’s central claim is that truths are absolute, for they are constituted by the dialectic between finitude and infinity, the consequence of which lies in the creation of the œuvre. Although love is often affected by individual difference, family, money, and social norms, philosophy calls for a rupture with these instances of finitude, awakening us to the truth that love is open to the possibility of infinity embodied by contingent encounter, amorous declaration, and the faithful construction of the Two. Badiou calls for subjectivization of this possibility in the form of the amorous œuvre, through and beyond the Lacanian impasse of the sexual non-relationship. This article supplements Badiouian love with Lacanian psychoanalysis by developing five points. First, the binary framework “Lacanian finitude vs Badiouian infinity” can be misleading. Second, Badiou himself regards the unconscious and the analytic discourse as inscribed by the dialectic between finitude and infinity. Third, Lacan allows us to recognize that the œuvre and the waste are not opposed, but rather supplementary to each other. Fourth, for both Lacan and Badiou, love constitutes the interlacing of the non-relationship and the Two. Fifth, the Badiouian amorous absolute must deal with the real of the absolute as the fusional One and thus, can be supplemented by the Lacanian problematic of the sexual relationship in its fantasmatic form of the One. Based on these points, this article elaborates such concepts as the amorous labor, the dialectic between œuvre and waste, and the artisan of love.
Style, identity and language shift
Authors: Abtahian Maya Ravindranath 
Published: July 2021

AbstractThis study is an examination of style-shifting in the speech of a single interviewer conducting sociolinguistic interviews in Garifuna (Arawak), an endangered language spoken in Belize and along the eastern coast of Central America. It provides a case study of intraspeaker variation in the context of language shift, exploring how the models and principles of intraspeaker variation hold in the social context of language shift scenarios, and framing language shift scenarios as particular contexts of performativity where cultural identity is highlighted. The focus of the paper is on the agentive use of a single phonetic variable in Garifuna as employed by the individual across speech events, as an example of how a linguistic form may become iconized in the context of language shift.
Stylistic variation in read Arabic
Authors: Horesh Uri 
Published: July 2021

AbstractThe study of variation in Arabic vernaculars has come a long way since its beginnings as a misguided endeavor to compare features in these contemporary dialects to cognate features in Standard Arabic (Classical or Modern) and view any differences as results of language change. We now recognize that the dialects and Standard Arabic have had different trajectories in different places and over a long period of time. The current study attempts to assess variation in a local variety of Modern Standard Arabic (MSA) and explore the methodological and theoretical advantages to consider what we already know about variation in the vernacular spoken by the same community whose reading in the Standard we are investigating. The paper draws a distinction between Prescribed MSA and a local variety thereof, as attested in recordings of a text read aloud by speakers of a Palestinian dialect, which were collected as part of a broader battery of sociolinguistic interviews in the speakers’ two dominant languages, Arabic and Hebrew. This is a pilot study, in which variationist methods of quantification and contextual analysis were employed, with the hope for setting the stage for more elaborate studies on the various stylistic repertoires available to speakers of Arabic.
High temperature magnetic characterisation of structural steels using Epstein frame
Authors: Wilson John W , Zhou Lei , Davis Claire L , Peyton Anthony J 
Published: July 2021

Abstract
Electromagnetic non-destructive testing techniques provide an attractive solution to the problem of monitoring microstructural changes in steels undergoing heat treatment as they are non-contact, have a short response time and are relatively inexpensive. However, to take full advantage of these techniques it is necessary to be able accurately measure the magnetisation characteristics of the materials of interest at temperatures up to the Curie point. This paper details the development of a novel high temperature Epstein frame for installation in a furnace with the design informed and results validated by finite element modelling. Hysteresis loop characteristics are successfully measured for a dual phase steel up to the Curie point for heating and cooling. Results show the developed system has the potential to provide valuable data to inform online electromagnetic monitoring systems.
Mechanical studies of the solid electrolyte interphase on anodes in lithium and lithium ion batteries
Authors: McBrayer Josefine D , Apblett Christopher A , Harrison Katharine L , Fenton Kyle R , Minteer Shelley D 
Published: July 2021

Abstract
A stable solid electrolyte interphase (SEI) layer is key to high performing lithium ion and lithium metal batteries for metrics such as calendar and cycle life. The SEI must be mechanically robust to withstand large volumetric changes in anode materials such as lithium and silicon, so understanding the mechanical properties and behavior of the SEI is essential for the rational design of artificial SEI and anode form factors. The mechanical properties and mechanical failure of the SEI are challenging to study, because the SEI is thin at only ~10–200 nm thick and is air sensitive. Furthermore, the SEI changes as a function of electrode material, electrolyte and additives, temperature, potential, and formation protocols. A variety of in situ and ex situ techniques have been used to study the mechanics of the SEI on a variety of lithium ion battery anode candidates; however, there has not been a succinct review of the findings thus far. Because of the difficulty of isolating the true SEI and its mechanical properties, there have been a limited number of studies that can fully de-convolute the SEI from the anode it forms on. A review of past research will be helpful for culminating current knowledge and helping to inspire new innovations to better quantify and understand the mechanical behavior of the SEI. This review will summarize the different experimental and theoretical techniques used to study the mechanics of SEI on common lithium battery anodes and their strengths and weaknesses.