bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection and characterization of replication origins defined by DNA polymerase epsilon
Authors: Jaksik Roman , Wheeler David A. , Kimmel Marek 
Published: July 2021

AbstractBackgroundAlthough the process of DNA replication is highly conserved the location of origins of replication (ORI) may vary from one tissue to the next or one round of replication to the next in eukaryotes, suggesting flexibility in the choice of locations to initiate replication. Lists of human ORI therefore vary widely in number and location and there are no methods available to compare them.ResultsHere we report the genome-wide localization of ORI in POLE-mutated human tumors using whole genome sequencing data. Mutations accumulated after many rounds of replication of unsynchronized dividing cell populations in tumors allow to identify constitutive origins, which we show are shared with high-fidelity between individuals and tumor types. Using a Smith–Waterman-like dynamic programming approach, we compared replication origin positions obtained from multiple different methods. The comparison allowed us to define a consensus set of replication origins, identified consistently by multiple ORI detection methods.ConclusionsMany DNA features co-localized with the consensus set of ORI, including chromatin loop anchors, G-quadruplexes, S/MARs and CpGs. Among all features, the H2A.Z histone exhibited the most significant association. Our results show that mutation-based detection of replication origins is a viable approach to determining their location and associated sequence features.
AlphaTims: Indexing trapped ion mobility spectrometry – time of flight data for fast and easy accession and visualization
Authors: Willems Sander , Voytik Eugenia , Skowronek Patricia , Strauss Maximilian T. , Mann Matthias 
Published: July 2021

AbstractHigh resolution mass spectrometry-based proteomics generates large amounts of data, even in the standard liquid chromatography (LC) – tandem mass spectrometry configuration. Adding an ion mobility dimension vastly increases the acquired data volume, challenging both analytical processing pipelines and especially data exploration by scientists. This has necessitated data aggregation, effectively discarding much of the information present in these rich data sets. Taking trapped ion mobility spectrometry (TIMS) on a quadrupole time-of-flight platform (Q-TOF) as an example, we developed an efficient indexing scheme that represents all data points as detector arrival times on scales of minutes (LC), milliseconds (TIMS) and microseconds (TOF). In our open source AlphaTims package, data are indexed, accessed and visualized by a combination of tools of the scientific Python ecosystem. We interpret unprocessed data as a sparse 4D matrix and use just-in-time compilation to machine code with Numba, accelerating our computational procedures by several orders of magnitude while keeping to familiar indexing and slicing notations. For samples with more than six billion detector events, a modern laptop can load and index raw data in about a minute. Loading is even faster when AlphaTims has already saved indexed data in a HDF5 file, a portable scientific standard used in extremely large-scale data acquisition. Subsequently, data accession along any dimension and interactive visualization happen in milliseconds. We have found AlphaTims to be a key enabling tool to explore high dimensional LC-TIMS-QTOF data and have made it freely available as an open-source Python package with a stand-alone graphical user interface at https://github.com/MannLabs/alphatims or as part of the AlphaPept ‘ecosystem’.HighlightsEasy visualization and fast accession of LC-TIMS-QTOF dataFreely available graphical user interface, command-line interface and Python module on Windows, Linux and macOS.
Assessment of flight dynamic and static aeroelastic behaviors for jet transport aircraft subjected to instantaneous high g-loads
Authors: Wang Yonghu , Chang Ray C. , Jiang Wei 
Published: July 2021

Purpose
The purpose of this paper is to present a quick inspection method based on the post-flight data to examine static aeroelastic behavior for transport aircraft subjected to instantaneous high g-loads.

Design/methodology/approach
In the present study, the numerical approach of static aeroelasticity and two verified cases will be presented. The non-linear unsteady aerodynamic models are established through flight data mining and the fuzzy-logic modeling of artificial intelligence techniques based on post-flight data. The first and second derivatives of flight dynamic and static aeroelastic behaviors, respectively, are then estimated by using these aerodynamic models.

Findings
The flight dynamic and static aeroelastic behaviors with instantaneous high g-load for the two transports will be analyzed and make a comparison study. The circumstance of turbulence encounter of the new twin-jet is much serious than that of four-jet transport aircraft, but the characteristic of stability and controllability for the new twin-jet is better than those of the four-jet transport aircraft; the new twin-jet transport is also shown to have very small aeroelastic effects. The static aeroelastic behaviors for the two different types can be assessed by using this method.

Practical implications
As the present study uses the flight data stored in a quick access recorder, an intrusive structural inspection of the post-flight can be avoided. A tentative conclusion is to prove that this method can be adapted to examine the static aeroelastic effects for transport aircraft of different weights, different sizes and different service years in tracking static aeroelastic behavior of existing different types of aircraft. In future research, one can consider to have more issues of other types of aircraft with high composite structure weight.

Originality/value
This method can be used to assist airlines to monitor the variations of flight dynamic and static aeroelastic behaviors as a complementary tool for management to improve aviation safety, operation and operational efficiency.
The culture of gifting with the emergence of online tourism experiential gift-giving
Authors: Gardiner Sarah , Bec Alexandra 
Published: July 2021

PurposeThis study aims to explore the evolution of the culture agapic (personal) gift-giving with the advent of new online gifting platforms that provide the opportunity to gift tourism experiences. This study investigates this well-established cultural behavior in view of this new form of social exchange.Design/methodology/approachFocus group interviews with two key target markets – mothers and couples/singles – were conducted (N = 39). Interview questions focused on understanding gifting using online platforms, sharing the experience and the role of various parties in the exchange.FindingsThis study reveals that experiential tourism gifts differ from physical gifts because they offer novelty and symbolic value, heighten positive emotions and have the potential to create lifelong memories for recipients. However, giving an experiential gift can also be a risky option because of the uncertainty of getting the gift–recipient identity match correct, particularly for adventure tourism gifts. The identity of the gift-giver is also considered in gift selection as the experience selected is a reflection of self.Practical implicationsIt is recommended that online experiential gifting platforms pay attention to both the identity of the gift-giver and gift-recipient. Sharing the experience through social media posts can reinforce both parties’ social identity, create a positive social exchange and may motivate repeat purchase.Originality/valueTo the best of the authors’ knowledge, this is the first study to uncover the motivational factors of online tourism experiential gifting as part of the culture of gift-giving and the parties in this exchange. The findings advance theoretical understanding of this new form of social exchange.
Is the new issue puzzle real? Evidence from implied cost of capital
Authors: Han Snow 
Published: July 2021

PurposeThis study aims to provide new explanation of the new issue puzzle.Design/methodology/approachThis study uses market implied cost of capital (ICC), rather than ex post realized returns, as proxy for ex ante expected returns, and sheds new light on the question why initial public offering (IPO) firms underperform the market within a 3–5 years period after the offerings.FindingsUsing ICC, the author finds that the market expects to earn higher risk premium for new listing firms than similar firms, which is contradictory to the documented new issue puzzle. The higher expected returns come from higher idiosyncratic volatility for newly listed firms, which are young and have more growth opportunities. The author also reports that investors are negatively surprised by lower-than-expected performances of newly listed firms.Originality/valueThe author’s results provide new empirical evidence that the new issue puzzle does not exist. Previous results observed IPO firms' under-performance is attributable to that ex post realized returns are a noisy proxy for ex ante expected returns, especially for newly listed firms with limited information.
The mediating effect of work engagement on the relationship between work–family conflict and turnover intention and moderated mediating role of supervisor support during global pandemic
Authors: Yucel Ilhami , Şirin Muhammed Sabri , Baş Murat 
Published: July 2021

PurposeThis paper aims to investigate whether there is a relationship between work–family conflict and turnover intention and whether work engagement has a mediating effect and supervisor support has a moderated mediation effect in this relationship.Design/methodology/approachThe sample of the study is composed of public hospital employees in Erzincan province. After removing the missing and incorrect ones from the questionnaires distributed to 1,044 employees of the hospital, 350 were evaluated. The data of the survey were analyzed and interpreted with statistical package programs. Regression analysis is used to investigate the association between the variables.FindingsThis paper finds significant negative associations of work–family conflict with work engagement and work engagement with turnover intention. A significant positive association is found between work–family conflict and turnover intention. In the meantime work engagement has a partial mediating effect on this relationship. Another important result of the research is that supervisor support has a moderator role between work–family conflict and work engagement and has a moderated mediation role at the model in which work–family conflict is independent, turnover intention is dependent and work engagement is a mediator variable.Research limitations/implicationsThe research was conducted only in Erzincan province with a limited number of participants, and only health sector employees were examined. It is possible to obtain distinct results in future research studies conducted on different sector employees. Moreover, only the work–family conflict variable was examined in the research. It is possible to expand the scope by also including the family–work conflict variable in future studies.Originality/valueThis research is the first study examining the mediating role of work engagement in the relationship between work–family conflict and turnover intention on healthcare employees in Turkey. Also, this paper is the first attempt to investigate moderated mediation model with the specified variables (work–family conflict, turnover intention, work engagement and supervisor support) in the model by using the frameworks of leader–member exchange and social exchange theories. This research answers research calls to study the moderating function of supervisor support during mediating role of work engagement, since the moderation impact clarifies the circumstances under which supervisor support is connected with the favorable results. This study also revealed how effective the supervisor support is on employees experiencing work–family conflict and their attitudes like work engagement and turnover intention. The consequences of such studies influence the way organizations handle and solve the problems in their organizations today. It takes into account moderated mediation modeling with the management subject in hospital employees.
Dark triad and situational variables and their relationship to career success and counterproductive work behaviors among employees in Turkey
Authors: Cohen Aaron , Özsoy Emrah 
Published: July 2021

PurposeThe purpose of this paper is to examine the relationship between dark triad personality (DTP) and organizational and individual counterproductive work behaviors (CWB) and perceived career success among employees in Turkey. Additionally, the study examined the effects of four situational variables: perceived organizational politics, transparency, psychological contract breach, and accountability.Design/methodology/approachData were collected from 156 employees across five service organizations in Sakarya, Turkey, using the survey method.FindingsThe regression analysis findings showed that the three traits of the DTP, Machiavellianism, and psychopathy were significantly related to both organizational and interpersonal dimensions of the CWB. Narcissism was not related to any of the dimensions of CWB. The findings showed no significant relationship between any of the four situational variables and the two forms of CWB. However, three of the situational variables were related to perceived career success, while the three dimensions of DTP were not.Research limitations/implicationsThe main limitations of this study are its cross-sectional design and the self-reported measures of the dependent variables. Interestingly, the study showed that having high levels of DTP does not necessarily promote their careers.Originality/valueThis study contributes to examining career success as a dependent variable in addition to CWB. The findings showed that situational variables are related to career success, and DTP is related to CWB. This finding has both conceptual and practical implications.
Expanding understanding of family social capital in crowdfunding of migrant entrepreneurial ventures
Authors: Arshad Nadia , Berndt Adele 
Published: July 2021

Purpose
The purpose of this study is to understand the role of the migrant entrepreneur’s social capital and specifically their family social capital in the success of their crowdfunding ventures.

Design/methodology/approach
This paper develops an exploratory single case study of the Persu Bag started by a Chinese migrant entrepreneur in the USA, which was documented through in-depth interviews, email communication, social media interactions and secondary documents publicly available. This paper draws on crowdfunding and social capital literature to fulfil the purpose and adopt the perspective of the migrant entrepreneur in the study.

Findings
The study shows that the crowdfunding migrant entrepreneur’s family network contributes with their operand and operant resources from both the country of residence and country of origin. Besides having financial capacity, institutional knowledge and experience from both the host and home countries, the family network in both countries make the crowdfunding immigrant entrepreneur’s families more resourceful, providing additional benefits to the crowdfunding migrant entrepreneurs in the development of the campaign and crowdfunded venture.

Originality/value
This study broadens the understanding of the ways migrant entrepreneurs can rely on their family social capital for building financial capacity and starting a crowdfunded venture.
Key driving factors of cost overrun in highway infrastructure projects in Nigeria: a context-based perspective
Authors: Mahmud Abba Tahir , Ogunlana Stephen O. , Hong W.T. 
Published: July 2021

Purpose
Extensive research towards identifying the attributable cost overrun factors globally has been conducted predominantly from a survey-oriented perspective, which disregard the contextual basis on which these triggers manifest. This study aims to explore the driving factors of cost overrun in highway projects, specific to the Nigerian context.

Design/methodology/approach
The research used a context-based approach to seek project stakeholders’ perspectives on the key drivers of cost overrun in highway projects in Nigerian. Semi-structured interviews were conducted with client, contractor and consultant organisations involved in the provision of highway infrastructure projects in Nigeria. The collected data was analysed using a developed coding framework grounded on a case study approach, principles of inductive thematic analysis and saliency analysis to identify the key drivers.

Findings
Findings from the analysis identified triggers from macroeconomic, societal, leadership and project management perspectives with synergistic relationships with each other based on prevalence and significance. Among the key triggers is a delay in work progress, political instability, adverse weather, social issues, delay in progress payment to contractors and modification of project scope. In conclusion, the triggers of cost overrun in highway projects are contextually driven by the complex nature of the project management, societal, macroeconomic and leadership triggers specific to the Nigerian context.

Research limitations/implications
The research was limited to only highway infrastructure projects in Nigeria. Furthermore, the findings are based on a small sample size, and thus, caution must be taken before applying the outcome of this study in a generalised way to other contexts.

Practical implications
Practically, the stakeholders i.e. client, contractors and consultants should acknowledge the contextual circumstances in which each of the triggers takes place, which will aid in developing pragmatic measures and make the right decisions towards addressing these triggers during any highway construction project in Nigeria and enhance the chances of project success.

Originality/value
The context-based approach applied in this study is expected to provide a new insight in understanding the triggers of cost overruns, especially in highway projects in Nigeria and indeed other developing countries with similar governance characteristics
Revisiting the impact of VR applications on hotel bookings
Authors: Yoon Sungsik , Erdem Mehmet , Schuckert Markus , Lee Patrick C. 
Published: July 2021

Purpose
The current study aims to investigate hotel guests’ intention to use virtual reality (VR) and willingness to pay more for hotels that have VR applications (e.g. virtual room tour) when booking a hotel.

Design/methodology/approach
Through a theoretical lens of stimuli–organism–response (S-O-R), relationships among an individual’s performance expectancy, effort expectancy, social influence, utilitarian motivation, hedonic motivation, perceived value, intention to use VR and willingness to pay more for VR were tested using partial least square-structural equation modeling.

Findings
Performance expectancy, social influence, utilitarian motivation and hedonic motivation affect the perceived value of VR. An individual’s perceived value of VR affects his/her intention to use VR and willingness to pay more for a hotel that has VR contents (e.g. virtual room tour) available during the hotel booking process.

Originality/value
Through the S-O-R framework, this study provided insights into hotel guests’ intention to use VR and explored how their intentions lead to their willingness to pay more for a hotel if VR is available during the reservation or hotel selection process.
Exploring the socio-cultural aspects of e-learning delivery in Saudi Arabia
Authors: Luppicini Rocci , Walabe Eman 
Published: July 2021

Purpose
This study aims to explore the socio-cultural aspects of e-learning delivery in Saudi universities from the perspectives of universities’ instructors and expert designers from the Ministry of Education. More specifically, this study examined the opportunities and challenges faced in the development of online learning environments at Saudi universities from a socio-cultural perspective.

Design/methodology/approach
This qualitative research study addressed pervasive socio-cultural challenges connected to e-learning delivery in Saudi Arabia. Data collection methods consisted of 28 in-depth insider expert interviews as well a thematic analysis of documents related to socio-cultural aspects of e-learning delivery in Saudi Arabia.

Findings
Findings from the data analysis uncovered two main thematic areas connected to e-learning delivery in Saudi Arabia, namely, culture and female access to e-learning.

Research limitations/implications
This research contributes original knowledge to international online learning research about the social and cultural complexity connected to online learning development in Saudi Arabia, as well as in other areas of the Arabic world where similar e-learning development initiatives are underway.

Practical implications
This research contributes original knowledge to international online learning research about the social and cultural complexity connected to online learning development in Saudi Arabia, as well as in other areas of the Arabic world where similar e-learning development initiatives are underway.

Social implications
This research contributes unique knowledge about the social and cultural complexity connected to online learning development in Saudi Arabia, as well as in other areas of the Arabic world where similar e-learning development initiatives are underway.

Originality/value
The interaction between Saudi culture and online learning has nurtured a unique learning model that adapts to cultural values to provide a quality learning experience.
The impact of knowledge flows on asset specificity from the perspective of open innovation
Authors: Zheng Feihu , Jiao Hao , Gu Junyi , Moon Hwy-Chang , Yin Wenyan 
Published: July 2021

Purpose
This study aims to examine how different modes of knowledge flows affect the changes of asset specificity and how ownership control moderates the relationship between knowledge flows and asset specificity in the open innovation paradigm.

Design/methodology/approach
This paper selects information technology outsourcing as the research base. It uses the feasible weighted least squares modeling method for its analysis and has collected the data from 2,369 research and development contracts of multinational vendor firms in China.

Findings
The coupled and outbound knowledge flows have a direct and positive effect on asset specificity. Moreover, the results show that weak corporate control has significant moderating effects on the relationship between both coupled and outbound knowledge flows and asset specificity; the strong control positively moderates the relationship between outbound knowledge flows and asset specificity.

Practical implications
In open innovation, firms build a higher degree of asset specificity to maximize the efficiency of knowledge flows, which then helps them to enhance innovation capacity and market performance.

Originality/value
Preceding studies have tended to examine the influences of asset specificity as an independent variable in a closed innovation paradigm. Asset specificity is hence often left as the antecedent “black box.” This paper, however, opens the “black box” of asset specificity, which is set as a dependent variable, by investigating the influences of knowledge flows on the asset specificity in the context of open innovation. It also reinterprets the role of asset specificity by adopting the lens of open innovation theory.