bluuebunny/crossref_metadata_2025_split huggingface dataset:
GUV-Net for high fidelity shoeprint generation
Authors: Hassan Muhammad , Wang Yan , Pang Wei , Wang Di , Li Daixi , Zhou You , Xu Dong 
Published: October 2021

AbstractShoeprints contain valuable information for tracing evidence in forensic scenes, and they need to be generated into cleaned, sharp, and high-fidelity images. Most of the acquired shoeprints are found with low quality and/or in distorted forms. The high-fidelity shoeprint generation is of great significance in forensic science. A wide range of deep learning models has been suggested for super-resolution, being either generalized approaches or application specific. Considering the crucial challenges in shoeprint based processing and lacking specific algorithms, we proposed a deep learning based GUV-Net model for high-fidelity shoeprint generation. GUV-Net imitates learning features from VAE, U-Net, and GAN network models with special treatment of absent ground truth shoeprints. GUV-Net encodes efficient probabilistic distributions in the latent space and decodes variants of samples together with passed key features. GUV-Net forwards the learned samples to a refinement-unit proceeded to the generation of high-fidelity output. The refinement-unit receives low-level features from the decoding module at distinct levels. Furthermore, the refinement process is made more efficient by inverse-encoded in high dimensional space through a parallel inverse encoding network. The objective functions at different levels enable the model to efficiently optimize the parameters by mapping a low quality image to a high-fidelity one by maintaining salient features which are important to forensics. Finally, the performance of the proposed model is evaluated against state-of-the-art super-resolution network models.
Comparative Study of SO2 and SO2/SO3 Poisoning and Regeneration of Cu/BEA and Cu/SSZ-13 for NH3 SCR
Authors: Auvray Xavier , Arvanitidou Maria , Högström Åsa , Jansson Jonas , Fouladvand Sheedeh , Olsson Louise 
Published: October 2021

AbstractTwo copper-exchanged zeolites, Cu/SSZ-13 and Cu/BEA, were studied as catalysts for the selective reduction of NOx by NH3 (NH3-SCR). Their activities for standard SCR (NOx = NO) and fast SCR (NOx = 50% NO + 50% NO2) were measured before and after sulfur poisoning at 250 °C. The effect of 30 ppm SO2 and a mixture of 24 ppm SO3 + 6 ppm SO2 was evaluated. The repetition of subsequent activity measurements served as regeneration method in SCR conditions. SO2 deactivated Cu/SSZ-13 whereas Cu/BEA was only moderately affected. SO3 led to stronger deactivation of both catalysts than SO2. However, also for this case, the Cu/BEA was significantly less affected than Cu/SSZ-13, even though Cu/BEA contained larger amount of stored sulfur. One possible reason for this could be the large pores of Cu/BEA, where the sulfur species possibly resulted in less sterical hindrance than in the small pore SSZ-13 structure. NH3 temperature-programmed desorption (NH3-TPD) showed no loss of storage sites upon sulfur treatment and subsequent regeneration. Partial activity recovery was observed after a period in SCR conditions at 400 °C and 500 °C. Temperature at 300 °C was insufficient to regenerate the catalysts. Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) of NO adsorption suggested that SO2 interacts with the ZCuOH sites on Cu/SSZ-13, causing the strong poisoning.
Equal values of certain partition functions via Diophantine equations
Authors: Tengely Szabolcs , Ulas Maciej 
Published: October 2021

AbstractLet $$A\subset \mathbb {N}_{+}$$

A
⊂

N
+

and by $$P_{A}(n)$$

P
A

(
n
)

denotes the number of partitions of an integer n into parts from the set A. The aim of this paper is to prove several result concerning the existence of integer solutions of Diophantine equations of the form $$P_{A}(x)=P_{B}(y)$$

P
A

(
x
)

=

P
B

(
y
)

, where A, B are certain finite sets.
Medication-related quality of life (MRQoL) in ambulatory older adults with multi-morbidity and polypharmacy
Authors: Jennings Emma L. M. , O’Mahony Denis , Gallagher Paul F. 
Published: October 2021

Abstract
Purpose
To assess medication-related quality-of-life (MRQoL) in multi-morbid older adults with polypharmacy and correlations with medications, frailty and health-related QoL.

Methods
With a cross sectional study of multi-morbid geriatric medicine outpatients, we assessed MRQoL (MRQol-LSv1), frailty status, potentially inappropriate medications, Medication Adherence Rating Scale (MARS), health-related-QoL (Short-Form 12, SF12) and medication burden (Living with Medicines Questionnaire, LMQv2).

Results
One-in-four (n = 59) of 234 outpatient attendees met inclusion criteria. Almost half (n = 106, 45%) were excluded due to cognition (MMSE < 26). Included participants (n = 27, mean age 80.2 years) experienced a median of 11 (IQR 9–13.5) co-morbidities and were prescribed a median of 10 (IQR 8–12.25) medications. Overall, MRQoL-LS.v.1 scores were low, suggesting good medication-related quality of life (median MRQoL-LS.v.1 score of 14, IQR 14–22). Correlations between MRQoL, number of daily medications, co-morbidity burden, LMQv2 score, SF12 scores and number of PIMs were non-significant.

Conclusion
MRQoL-LSv.1 is unsuitable for most patients attending geriatric ambulatory services.
Emotional cognition subgroups in unaffected first-degree relatives of patients with mood disorders
Authors: Kjærstad Hanne Lie , Varo Cristina , Meluken Iselin , Vieta Eduard , Vinberg Maj , Kessing Lars Vedel , Miskowiak Kamilla Woznica 
Published: October 2021

AbstractBackgroundPatients with major depressive disorder (MDD) or bipolar disorder (BD) exhibit difficulties with emotional cognition even during remission. There is evidence for aberrant emotional cognition in unaffected relatives of patients with these mood disorders, but studies are conflicting. We aimed to investigate whether emotional cognition in unaffected first-degree relatives of patients with mood disorders is characterised by heterogeneity using a data-driven approach.MethodsData from 94 unaffected relatives (33 of MDD patients; 61 of BD patients) and 203 healthy controls were pooled from two cohort studies. Emotional cognition was assessed with the Social Scenarios Test, Facial Expression Recognition Test and Faces Dot-Probe Test. Hierarchical cluster analysis was conducted using emotional cognition data from the 94 unaffected relatives. The resulting emotional cognition clusters and controls were compared for emotional and non-emotional cognition, demographic characteristics and functioning.ResultsTwo distinct clusters of unaffected relatives were identified: a relatively ‘emotionally preserved’ cluster (55%; 40% relatives of MDD probands) and an ‘emotionally blunted’ cluster (45%; 29% relatives of MDD probands). ‘Emotionally blunted’ relatives presented with poorer neurocognitive performance (global cognition p = 0.010), heightened subsyndromal mania symptoms (p = 0.004), lower years of education (p = 0.004) and difficulties with interpersonal functioning (p = 0.005) than controls, whereas ‘emotionally preserved’ relatives were comparable to controls on these measures.ConclusionsOur findings show discrete emotional cognition profiles that occur across healthy first-degree relatives of patients with MDD and BD. These emotional cognition clusters may provide insight into emotional cognitive markers of genetically distinct subgroups of individuals at familial risk of mood disorders.
INVOLVEMENT LOAD HYPOTHESIS PLUS
Authors: Yanagisawa Akifumi , Webb Stuart 
Published: October 2021

AbstractThe present meta-analysis aimed to improve on Involvement Load Hypothesis (ILH) by incorporating it into a broader framework that predicts incidental vocabulary learning. Studies testing the ILH were systematically collected and 42 studies meeting our inclusion criteria were analyzed. The model-selection approach was used to determine the optimal statistical model (i.e., a set of predictor variables) that best predicts learning gains. Following previous findings, we investigated whether the prediction of the ILH improved by (a) examining the influence of each level of individual ILH components (need, search, and evaluation), (b) adopting optimal operationalization of the ILH components and test format grouping, and (c) including other empirically motivated variables. Results showed that the resulting models explained a greater variance in learning gains. Based on the models, we created incidental vocabulary learning formulas. Using these formulas, one can calculate the effectiveness index of activities to predict their relative effectiveness more accurately on incidental vocabulary learning.
Nutrition knowledge assessment tools for older adults and their carers: a scoping review
Authors: Chin Shuyan , Wong Raymond , Hirani Vasant , O’Leary Fiona 
Published: October 2021

AbstractPoor nutritional intake is common among older adults. Given that nutrition knowledge is an important determinant of eating behaviour and nutritional status, understanding areas of inadequate knowledge can guide educational interventions to reduce risk of nutritional deficiencies and promote healthy ageing. This review investigated tools assessing general nutritional knowledge of older adults and their carers. Following the Joanna Briggs for Scoping Reviews guidelines, 4 databases (MEDLINE, CINAHL, Global Health and Embase) and grey literature were searched. Studies of any type containing general nutrition knowledge assessment tools for older adults or their carers were included. In total, 6934 articles were identified, of which 24 met the eligibility criteria, and 23 unique nutrition knowledge assessment tools were included. Of these tools, 14 were original, 6 were modified from other tools and 3 used dietary-related responses from national dietary survey questions. 6 tools were developed for carers (mostly nurses) and 17 tools for older adults. Tools had between 4 and 110 items. The most common topics for general nutrition knowledge questions were related to nutrients and roles, food sources of nutrients, and diet–disease relationships. 8 tools were developed prior to 2000. Most studies did not specify or assess psychometric properties of the tool, with only 9 (38 %) and 6 (26 %) studies testing for reliability and validity, respectively, and only 1 tool was considered reliable. Additional research for the development of reliable and validated tools or the validation of existing tools to assess nutrition knowledge of older adults and their carers is needed across different healthcare settings.
Monitoring Tree Sway as an Indicator of Interception Dynamics Before, During, and Following a Storm
Authors: Ciruzzi Dominick M. , Loheide Steven P. 
Published: October 2021

AbstractUnderstanding the role of trees in attenuating the timing and magnitude of effective precipitation reaching the land surface requires improved monitoring of interception dynamics. We developed a new field monitoring approach to leverage continuous monitoring of tree sway motion in quantifying continuous, dynamic time series of canopy water storage during storms. Using this approach, we additionally observed a hysteretic interception response in tree canopies, which indicates that interpreting interception processes through tree sway signals requires the consideration of changing water (i.e., mass) distribution during and following storms. These findings suggest that continuously monitoring tree sway motions offers a new technique to quantify interception processes. This advancement in whole tree interception may help improve our understanding of how interception affects ecosystem water availability/productivity and runoff dynamics that are important for both natural ecosystems and stormwater management in cities.
Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma
Authors: Newman Alexander M. , Zaka Masood , Zhou Peixun , Blain Alex E. , Erhorn Amy , Barnard Amy , Crossland Rachel E. , Wilkinson Sarah , Enshaei Amir , De Zordi Julian , Harding Fiona , Taj Mary , Wood Katrina M. , Televantou Despina , Turner Suzanne D. , Burke G. A. Amos , Harrison Christine J. , Bomken Simon , Bacon Chris M. , Rand Vikki 
Published: October 2021

AbstractChildren with B-cell non-Hodgkin lymphoma (B-NHL) have an excellent chance of survival, however, current clinical risk stratification places as many as half of patients in a high-risk group receiving very intensive chemo-immunotherapy. TP53 alterations are associated with adverse outcome in many malignancies; however, whilst common in paediatric B-NHL, their utility as a risk classifier is unknown. We evaluated the clinical significance of TP53 abnormalities (mutations, deletion and/or copy number neutral loss of heterozygosity) in a large UK paediatric B-NHL cohort and determined their impact on survival. TP53 abnormalities were present in 54.7% of cases and were independently associated with a significantly inferior survival compared to those without a TP53 abnormality (PFS 70.0% vs 100%, p < 0.001, OS 78.0% vs 100%, p = 0.002). Moreover, amongst patients clinically defined as high-risk (stage III with high LDH or stage IV), those without a TP53 abnormality have superior survival compared to those with TP53 abnormalities (PFS 100% vs 55.6%, p = 0.005, OS 100% vs 66.7%, p = 0.019). Biallelic TP53 abnormalities were either maintained from the presentation or acquired at progression in all paired diagnosis/progression Burkitt lymphoma cases. TP53 abnormalities thus define clinical risk groups within paediatric B-NHL and offer a novel molecular risk stratifier, allowing more personalised treatment protocols.
Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [11C]PHNO PET
Authors: Rabiner Eugenii A. , Uz Tolga , Mansur Ayla , Brown Terry , Chen Grace , Wu Jingtao , Atienza Joy , Schwarz Adam J. , Yin Wei , Lewis Yvonne , Searle Graham E. , Dennison Jeremy M. T. J. , Passchier Jan , Gunn Roger N. , Tauscher Johannes 
Published: October 2021

AbstractThe use of positron emission tomography (PET) in early-phase development of novel drugs targeting the central nervous system, is well established for the evaluation of brain penetration and target engagement. However, when novel targets are involved a suitable PET ligand is not always available. We demonstrate an alternative approach that evaluates the attenuation of amphetamine-induced synaptic dopamine release by a novel agonist of the orphan G-protein-coupled receptor GPR139 (TAK-041). GPR139 agonism is a novel candidate mechanism for the treatment of schizophrenia and other disorders associated with social and cognitive dysfunction. Ten healthy volunteers underwent [11C]PHNO PET at baseline, and twice after receiving an oral dose of d-amphetamine (0.5 mg/kg). One of the post-d-amphetamine scans for each subject was preceded by a single oral dose of TAK-041 (20 mg in five; 40 mg in the other five participants). D-amphetamine induced a significant decrease in [11C]PHNO binding potential relative to the non-displaceable component (BPND) in all regions examined (16–28%), consistent with increased synaptic dopamine release. Pre-treatment with TAK-041 significantly attenuated the d-amphetamine-induced reduction in BPND in the a priori defined regions (putamen and ventral striatum: 26% and 18%, respectively). The reduction in BPND was generally higher after the 40 mg than the 20 mg TAK-041 dose, with the difference between doses reaching statistical significance in the putamen. Our findings suggest that TAK-041 enters the human brain and interacts with GPR139 to affect endogenous dopamine release. [11C]PHNO PET is a practical method to detect the effects of novel drugs on the brain dopaminergic system in healthy volunteers, in the early stages of drug development.
Advances in the curative management of oesophageal cancer
Authors: Bolger Jarlath C. , Donohoe Claire L. , Lowery Maeve , Reynolds John V. 
Published: October 2021

AbstractThe incidence of oesophageal cancer, in particular adenocarcinoma, has markedly increased over the last four decades with adenocarcinoma becoming the dominant subtype in the West, and mortality rates are high. Nevertheless, overall survival of patients with oesophageal cancer has doubled in the past 20 years, with earlier diagnosis and improved treatments benefiting those patients who can be treated with curative intent. Advances in endotherapy, surgical approaches, and multimodal and other combination therapies have been reported. New vistas have emerged in targeted therapies and immunotherapy, informed by new knowledge in genomics and molecular biology, which present opportunities for personalised cancer therapy and novel clinical trials. This review focuses exclusively on the curative intent treatment pathway, and highlights emerging advances.
Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells
Authors: Schroeder Barbara , Vander Steen Travis , Espinoza Ingrid , Venkatapoorna Chandra M. Kurapaty , Hu Zeng , Silva Fernando Martín , Regan Kevin , Cuyàs Elisabet , Meng X. Wei , Verdura Sara , Arbusà Aina , Schneider Paula A. , Flatten Karen S. , Kemble George , Montero Joan , Kaufmann Scott H. , Menendez Javier A. , Lupu Ruth 
Published: October 2021

AbstractInhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However, little is known about the molecular determinants of cancer cell sensitivity to FASN inhibitors (FASNis), which is a major roadblock to their therapeutic application. Here, we find that pharmacological starvation of endogenously produced FAs is a previously unrecognized metabolic stress that heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors. Evaluation of the death decision circuits controlled by the BCL-2 family of proteins revealed that FASN inhibition is accompanied by the upregulation of the pro-death BH3-only proteins BIM, PUMA, and NOXA. Cell death triggered by FASN inhibition, which causally involves a palmitate/NADPH-related redox imbalance, is markedly diminished by concurrent loss of BIM or PUMA, suggesting that FASN activity controls cancer cell survival by fine-tuning the BH3 only proteins-dependent mitochondrial threshold for apoptosis. FASN inhibition results in a heightened mitochondrial apoptosis priming, shifting cells toward a primed-for-death state “addicted” to the anti-apoptotic protein BCL-2. Accordingly, co-administration of a FASNi synergistically augments the apoptosis-inducing activity of the dual BCL-XL/BCL-2 inhibitor ABT-263 (navitoclax) and the BCL-2 specific BH3-mimetic ABT-199 (venetoclax). FASN inhibition, however, fails to sensitize breast cancer cells to MCL-1- and BCL-XL-selective inhibitors such as S63845 and A1331852. A human breast cancer xenograft model evidenced that oral administration of the only clinically available FASNi drastically sensitizes FASN-addicted breast tumors to ineffective single-agents navitoclax and venetoclax in vivo. In summary, a novel FASN-driven facet of the mitochondrial priming mechanistically links the redox-buffering mechanism of FASN activity to the intrinsic apoptotic threshold in breast cancer cells. Combining next-generation FASNis with BCL-2-specific BH3 mimetics that directly activate the apoptotic machinery might generate more potent and longer-lasting antitumor responses in a clinical setting.
What makes a plant-based diet? a review of current concepts and proposal for a standardized plant-based dietary intervention checklist
Authors: Storz Maximilian Andreas 
Published: October 2021

AbstractWithin the last decades, plant-based diets have received increasing interest for their potential benefits to human and environmental health. The concept of plant-based diet, however, varies widely in its definition. Current definitions range from the exclusion of all animal products to diets that include meat, fish, and dairy in varying quantities. Therefore, the main objectives of this review were twofold: (a) to investigate how researchers use the term plant-based diet in nutrition intervention studies and (b) what types of food a plant-based diet may include. Searching two databases, we found that the term “plant-based diet” evokes varying ideas to researchers and clinicians. Fifty percent of the retrieved studies that included a plant-based dietary intervention completely proscribed animal products and used the term plant-based diet interchangeably with a vegan diet. In contrast, an ~33% of trials included dairy products and 20% of dietary interventions emphasized a semi-vegetarian dietary pattern. Based on specific examples, we point out how the usage of the umbrella term “plant-based diet” may cause significant ambiguity. We often encountered incomplete descriptions of plant-based dietary interventions, which makes comparison and reproducibility of studies difficult. As a consequence, we urge others to use the term “plant-based diet” only in conjunction with a detailed dietary description. To facilitate this process, we provide a template of a standardized plant-based intervention reporting checklist. Finally, the present review also highlights the urgent need for a consensus definition of the term plant-based diet and its content.
StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells
Authors: Labouesse Céline , Tan Bao Xiu , Agley Chibeza C. , Hofer Moritz , Winkel Alexander K. , Stirparo Giuliano G. , Stuart Hannah T. , Verstreken Christophe M. , Mulas Carla , Mansfield William , Bertone Paul , Franze Kristian , Silva José C. R. , Chalut Kevin J. 
Published: October 2021

AbstractStudies of mechanical signalling are typically performed by comparing cells cultured on soft and stiff hydrogel-based substrates. However, it is challenging to independently and robustly control both substrate stiffness and extracellular matrix tethering to substrates, making matrix tethering a potentially confounding variable in mechanical signalling investigations. Moreover, unstable matrix tethering can lead to poor cell attachment and weak engagement of cell adhesions. To address this, we developed StemBond hydrogels, a hydrogel in which matrix tethering is robust and can be varied independently of stiffness. We validate StemBond hydrogels by showing that they provide an optimal system for culturing mouse and human pluripotent stem cells. We further show how soft StemBond hydrogels modulate stem cell function, partly through stiffness-sensitive ERK signalling. Our findings underline how substrate mechanics impact mechanosensitive signalling pathways regulating self-renewal and differentiation, indicating that optimising the complete mechanical microenvironment will offer greater control over stem cell fate specification.