bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Vigorous Resistance Training On Cardiovagal Baroreflex Sensitivity: A Cross-Sectional Study
Authors: Nakamura Nobuhiro , Muraoka Isao 
Published: April 2021

Abstract
Background: Blunted cardiovagal baroreflex sensitivity (BRS) is correlated with elevation of central arterial stiffness and/or reduction of arterial compliance with aging. Resistance-trained who habitually perform vigorous resistance training (RT) may blunt cardiovagal BRS due to an increase in central arterial stiffness and a decrease in arterial compliance. Therefore, the purpose of this study was to examine the effect of vigorous RT on cardiovagal BRS in a cross-sectional study to compare resistance-trained with age-matched non-resistance-trained.Methods: This cross-sectional study included resistance-trained men (resistance-trained group: n = 20) and age-matched non-resistance-trained men (control group: n = 20). The β-stiffness index and arterial compliance were assessed at the right carotid artery, and the cardiovagal BRS was estimated by the slope of the R-R interval and systolic blood pressure during phase IV of the Valsalva maneuver.Results: The β-Stiffness index was significantly higher in the resistance-trained group than in the control group (4.4 ± 0.2 vs. 5.9 ± 0.3 a.u., P < 0.01). In contrast, the resistance-trained group had significantly lower arterial compliance and cardiovagal BRS than the control group (0.20 ± 0.01 vs. 0.15 ± 0.01 mm2/mmHg and 12.9 ± 1.2 vs. 9.0 ± 0.5 ms/mmHg, respectively, P < 0.01 for both measurements). Moreover, cardiovagal BRS was inversely and positively correlated with the β-stiffness index (combined: r = - 0.59, P < 0.01; control: r = - 0.56, P < 0.01; resistance-trained: r = - 0.50, P < 0.05) and arterial compliance (combined: r = 0.64; control: r = 0.61; resistance-trained: r = 0.55, all P < 0.01), respectively. Conclusion: Resistance-trained group was higher arterial stiffness and lower compliance and blunter cardiovagal BRS compared with control group. These results suggest that vigorous RT blunts cardiovagal BRS.Trial registration: University hospital Medical Information Network (UMIN) in Japan, UMIN000038116. Registered on September 27, 2019.
Prevalence and risk factors of silent obstructive sleep apnea in patients with dentofacial deformities
Authors: Jokaji Rei , Ooi Kazuhiro , Takamichi Sayuri , Nakade Yusuke , Kawashiri Shuichi , Kasahara Kazuo , Nakata Masako 
Published: April 2021

Abstract
Objective

Prevalence of silent obstructive sleep apnea (OSA) in patients with dentofacial deformities is unknown, although OSA is severe risk of airway obstruction in perioperative orthognathic surgery or complication after surgery. The aim of this study was to investigate prevalence and risk factors of silent OSA in patients with dentofacial deformities.
Methods

We analyzed 72 patients (24 male, 48 female) with dentofacial deformities without previous OSA symptoms. Polysomnography was performed before orthognathic surgery. Prevalence and risk factors of silent OSA were statistically analyzed as related to Apnea hypopnea index (AHI).
Results

Mean AHI was 1.6 (range: 0-12.1) /h. Three patients of 72 patients (4.1%) were diagnosed silent OSA. AHI during REM sleep phase 3.7 (0-32.3) was higher than AHI during NREM sleep phase 1.0 (0-9.7). AHI of male patients was higher than that of female. AHI was increased according to high BMI. AHI was higher in deep bite than open bite, edge to edge bite and nomal bite. AHI of mandibular asymmetry cases were higher than that of symmetry cases.
Conclusions

The prevalence of silent OSA was 4.1%. Obesity, male, deep bite, mandibular asymmetry and REM sleep phase were risk factors of silent OSA.
The Effect of Public Reporting of Acute Myocardial Infarction on the Choice of Hospital
Authors: Chae Kyunghee , Kim Mira , Jung Chai-Young , Lee Sangmin , Quan Hude , Kim Sukil 
Published: April 2021

Abstract
BackgroundPublic reporting of the quality of care delivered in hospitals is thought to improve patients’ choice and quality of care. When information about hospital rating is available, consumers may choose good-rated hospitals. To investigate the effect of public reporting of acute myocardial infarction (AMI) care on the people’s choice of hospitals. MethodsWe conducted a cross-sectional study using an online questionnaire. The survey questions include the awareness and usage of public reporting, and the impact of the public reporting on the choice of hospitals. The difference in responses before and after acquiring information about public reporting was compared using Wilcoxon Signed Rank test.ResultsThe final survey data set includes 740 respondents after a rigorous validity check (response rate: 66.7%). Before providing information about public reporting of AMI care, 62.8% of respondents selected ‘nearby hospitals’ as the best option for AMI patients, followed by ‘famous hospitals’ (14.4%), ‘usual hospitals’ (10.5%) and ‘hospitals with good rates’ (9.9%). However, after acquiring information about the public reporting of AMI care, 10.3% of respondents changed their original responses to ‘hospitals with good rates’. Among the factors of hospital choice that differ before and after obtaining public reporting information, 'nearby hospitals' and 'hospitals with good rates' increased, while 'usual hospitals’ and 'famous hospitals' decreased. Compared to the health-related occupation group, the non-health related occupation group showed a significant difference between 'famous hospitals', and 'hospitals with good rates' before and after obtaining information (Famous hospitals p=0.003, Hospitals with good rates p=0.002).ConclusionsThe publicly available hospital quality ratings influence people’s choice of hospital, increasing the risk of selecting a hospital with a good rating than the nearest hospital, which is recommended for AMI patients. Policy-makers need to stress the importance of choosing the nearest hospital when AMI symptoms occur, in addition to hospital ratings, in the public reporting.
An Open-source Model for Simulation and Corrective Measure Assessment of the 2021 Texas Power Outage
Authors: Wu Dongqi , Zheng Xiangtian , Xu Yixing , Olsen Daniel , Xia Bainan , Singh Chanan , Xie Le 
Published: April 2021

Abstract
Unprecedented winter storms that hit across Texas in February 2021 have caused at least 4.5 million customers to experience load shedding due to the wide-ranging generation capacity outage and record-breaking electricity demand.
While much remains to be investigated on what, how, and why such wide-spread power outages occurred across Texas, it is imperative for the broader research community to develop insights based on a coherent electric grid model and data set. In this paper, we collaboratively release an open-source large-scale baseline model that is synthetic but nevertheless provides a realistic representation of the actual energy grid, accompanied by open-source cross-domain data sets. Leveraging the synthetic grid model, we reproduce the blackout event and critically assess several corrective measures that could have mitigated the blackout under such extreme weather conditions. We uncover the regional disparity of load shedding. The analysis also quantifies the sensitivity of several corrective measures with respect to mitigating the power outage, as measured in energy not served (ENS). This approach and methodology are generalizable for other regions experiencing significant energy portfolio transitions.
Bacteria associated with the intestinal tract of three predators of Dactylopius opuntiae (Hemiptera: Dactylopiidae)
Authors: Martínez-Martínez Susana , Rodríguez-Leyva Esteban , Aranda-Ocampo Sergio , Santillán-Galicia Ma.Teresa , Hernández-López Antonio , Guzmán-Franco Ariel Wilbert 
Published: April 2021

Abstract
Insects depend on gut bacteria for many metabolic functions including detoxification. Dactylopius (Hemiptera: Dactylopiidae) species (e.g. D. opuntiae and D. coccus) produce carminic acid possibly acting as part of their immune response to predation; thus predators of Dactylopius species may require intestinal symbionts to metabolize carminic acid acquired from their prey. The average content of carminic acid in D. opuntiae and D. coccus is 3–5% and 19–25% respectively; the predators Leucopina bellula and Hyperaspis trifurcata are specialists on D. opuntiae while Laetilia coccidivora feeds on both D. opuntiae and D. coccus. We determined the diversity of bacteria associated with the gut of these predators to test the hypothesis that it would vary significantly depending on the level of prey specialism. Bacteria were isolated from the intestine of Le. bellula, L. coccidivora and H. trifurcata larvae and also adults of H. trifurcata. Bacteria were identified morphologically and by partial sequencing of the 16S rRNA gene. The greatest bacterial diversity was found in L. coccidivora and H. trifurcata adults, followed by H. trifurcata larvae. The lowest diversity was found in Le. bellula. Sequencing revealed the presence of Bacillus cereus, Enterococcus gallinarum and E. casseliflavus in L. coccidivora larvae; Enterobacter sp. in larvae of H. trifurcata; Lactococcus lactis in adults of H. trifurcate; and Staphylococcus sp. in larvae and adults of H. trifurcate. Bacillus pumilus was only found in Le. bellula. The possible role of these bacteria in the ability of predators to feed on D. opuntiae and D. coccus is discussed.
Neutrophil-to-Lymphocyte Ratio is a Prognostic Predictive Factor for Local Advanced Lower Rectal Cancer Treated with Curative Surgical Treatment after Neoadjuvant Chemoradiotherapy:&nbsp;A&nbsp;Single-Center Retrospective Cohort Study
Authors: Nakagawa Ryosuke , Ogawa Shimpei , Inoue Yuji , Ohki Takeshi , Bamba Yoshiko , Koshino Kurodo , Tani Kimitaka , Aihara Hisako , Itabashi Michio , Yamamoto Masakazu 
Published: April 2021

Abstract
Background: The neutrophil-to-lymphocyte ratio (NLR) correlates with relapse-free survival (RFS) and may be a predictor of recurrence in patients after curative surgery for colorectal cancer. This study aimed to analyze the long-term oncological outcomes of locally advanced lower rectal cancer treated with curative surgery after neoadjuvant chemoradiotherapy (nCRT) to examine the prognostic value of the NLR and to evaluate the fluctuation of pre- and post-CRT NLR as recurrence risk factors.Methods: Fifty-two patients who underwent curative surgery were enrolled between 2009 and 2016. A cut-off pre-CRT NLR of 3.20 was used based on receiver-operating characteristic curve analysis. The primary outcome was RFS. Factors influencing recurrence after treatment according to fluctuations between the pre- and post-CRT NLR were also analyzed.Results: Univariate analysis was performed using 17 clinicopathological factors thought to affect RFS. A significant difference was found in the pre-CRT NLR (hazard ratio [HR]: 7.626, 95% confidence interval [CI]: 2.760-21.06, p<0.0001), operation time (HR: 2.949, 95% CI: 1.137-7.646, p=0.0261), and pathological T stage (HR: 8.342, 95% CI: 2.458-28.306 p=0.0007). RFS according to the pre-CRT NLR using Kaplan–Meier analysis showed that the group with pre-CRT ≥3.20 had a lower 5-year RFS (p=0.001). A lower pre-CRT NLR resulted in a significantly higher recurrence rate, regardless of the increase or decrease in the pre- and post-CRT NLR.Conclusions: The pre-CRT NLR may be a predictor of prognosis in patients with locally advanced lower rectal cancer after nCRT.
Downregulation of LANCL1-AS1 Promotes Tumorigenesis in Lung Adenocarcinoma Via the Modulation of miR-6748a-3p/PRSS8 Axis
Authors: Nie Guangjie , Liu Jun , Liang Jiakang , Yuan Yi 
Published: April 2021

Abstract
Background: Lung adenocarcinoma (LUAD) is one of the deadliest types of cancer worldwide. Previous studies have reported that the expression of LANCL1-AS1 was decreased in LUAD. Hence, the current study was conducted to confirm these findings and explore the probable mechanism of action.Methods: LUAD and adjacent tissue samples were collected after the surgical procedure. For experiments in vitro, CCK-8 assay and colony formation assay were employed to explore the proliferation capacity while transwell assay was performed to explore the migration and invasion ability of LUAD cell lines. Luciferase reporter assay and RNA pull-down assay were used to confirm the interaction between LANCL1-AS1 and corresponding miRNA as well as the corresponding protein target of the miRNA predicted by online bioinformatics tools. The effect of different interventions on RNA and protein expression was confirmed by qRT-PCR and western blotting.Results: It was observed that LANCL1-AS1 was low expressed in LUAD tissues and cell lines which was also associated with decreased survival of cancer patients. Overexpression of LANCL1-AS1 in cell lines was associated with decreased viability, proliferation, migration, and invasion, and with decreased subcutaneous tumor growth in nude mice. RNA pull-down and luciferase reporter gene assays suggested that LANCL1-AS1 interacted with miR-6748a-3p and LUAD tissue samples exhibited increased expression of miR-6748a-3p. Moreover, miR-6748-3p mimics decreased the RNA and protein expression of PRSS8 in LUAD cell lines. Interestingly, LUAD tissue samples exhibited low expression of PRSS8. The effects of LANCL1-AS1 overexpression on viability, proliferation, migration, and invasion capacity of LUAD cell lines were curtailed after the miR-6748a-3p overexpression or PRSS8 silencing. Conclusion: Our results suggest that upregulation of LANCL1-AS1 can suppress tumor growth in LUAD through the modulation of miR-6748a-3p and PRSS8 dependent pathways.
A close association of freedom from pain, migraine-related functional disability, and other outcomes: Results of a post hoc analysis of randomized lasmiditan studies SAMURAI and SPARTAN
Authors: Lipton Richard B , Baygani Simin K , Tepper Stewart J , Krege John H , Vasudeva Raghavendra , Pearlman Eric M , Hauck Paula , Loo Li Shen 
Published: April 2021

Abstract
BackgroundWhile pain freedom at 2h is a key primary outcome for current trials for acute treatment of migraine, the relationship between the degree of head pain and other efficacy measures at 2h has rarely been explored. Following lasmiditan treatment of a migraine attack with moderate or severe head pain, we contrast those who achieve pain freedom with those who achieve mild pain but not pain freedom 2h post dosing.MethodsPatient-level data were pooled across studies and treatment arms from two Phase 3 trials comparing lasmiditan and placebo, SAMURAI and SPARTAN. This post hoc analysis assessed freedom from the most bothersome symptom (MBS), freedom from migraine-related functional disability (disability), and improved patient global impression of change (PGIC) in patients who achieved 2h pain freedom compared to those who experienced 2h mild pain. Mild pain differs from pain relief which is defined as either mild pain or pain freedom.ResultsParticipants who achieved 2h pain freedom (N = 913), in comparison with those with 2h mild pain (N = 864), were significantly more likely to experience MBS freedom (91.9% vs. 44.9%), disability freedom (87.1% and 13.4%), and improved PGIC (86.5% and 31.5%) (p < 0.001 for all combinations). In addition, more patients who were pain free experienced both 2h MBS freedom and 2h functional disability freedom (83.6%) compared to those with mild pain (10.8%; p < 0.001). The proportion of patients with pain freedom who did not achieve either MBS or disability freedom was lower (4.6%) than in patients with mild pain (52.4%). Lastly, 55.2% of patients experienced mild pain before disability freedom compared to 72.1% who experienced pain freedom and disability freedom at the same time.ConclusionsThis study demonstrated that, at 2h post treatment, patients who were pain free were more likely to achieve other outcomes including freedom from their MBS, freedom from migraine-related functional disability, and improved PGIC compared to those with mild pain, confirming that 2h pain freedom is more robustly associated with other clinical outcomes than the 2h mild pain endpoint.Trial RegistrationSAMURAI (NCT02439320); SPARTAN (NCT02605174).
The effects of virtual reality exercise on the physical performance and fatigue of active young men in single-stage aerobic and anaerobic running
Authors: naji sara , Shabkhiz Fatemeh , Rezaei Mohammad Hossein , Derakhshi Elahe , Kordi Mohammad Reza 
Published: April 2021

Abstract
Objective: Exercise with virtual reality (VR) is a novel approach to the promotion of health and the components of fitness. Our objective was to investigate the effects of exercise with VR on physical performance, mental fatigue, and physical fatigue in single-stage aerobic and anaerobic running.Materials and Methods: Twenty physically active, healthy, age-matched male university students executed the exercise test in aerobic and anaerobic groups in two separate sessions of VR (first-person perspective in a simulator) and non-VR (traditionally in the laboratory). The simulated environment was a graphic tunnel route. The aerobic and anaerobic groups engaged in the Bruce protocol and anaerobic speed test, respectively. Exercise test duration, blood serum lactate concentration, rating of fatigue (ROF), and heart rate were recorded at the end of both sessions.Results: Intragroup comparisons using the dependent t-test indicated that the exercise test duration significantly increased in the VR session of the anaerobic group compared to the traditional method considering the effect size (t7=0.804; P=0.804). However, the test duration remained unchanged in both sessions of the aerobic group (t9=1.373; P=0.203). Serum lactate concentration significantly decreased in the VR session compared to the non-VR session in the aerobic group (t9=4.734; P=0.001) and anaerobic group (t9=2.321; P=0.045). ROF and heart rate of the aerobic and anaerobic groups remained unchanged in both sessions.Conclusion: The findings indicated that as an alternative for improving physical performance in exercise, running with VR in an imaginative virtual environment decreased physical fatigue in a single stage of aerobic and anaerobic running.
Complete Remission of Metastatic Osteosarcoma using Combined Modality Therapy: A Retrospective Analysis of Unselected Patients in China
Authors: Xie Lu , Xu Jie , Li Xiaowei , Zhou Zuli , Zhuang Hongqing , Sun Xin , Liu Kuisheng , Liu Xingyu , Sun Kunkun , Wu Yiming , Gu Jin , Guo Wei 
Published: April 2021

Abstract
Background
Complete surgical remission (CSR) is the best predictor of overall survival (OS) for patients with metastatic osteosarcoma. However, metastasectomy has not been widely implemented in China in the last decade due to various factors, and instead, most physicians choose hypofractionated radiotherapy to treat pulmonary lesions. This study aimed to retrospectively evaluate the outcomes of different local treatments for pulmonary lesions and identify the best local therapy strategies for these patients.
Methods
We reviewed the clinical courses of osteosarcoma patients with pulmonary metastases who were initially treated in two sarcoma centres in Beijing, China, from June 1st, 2009, to March 26th, 2020. With a median follow-up of 32.4 (95% confidence interval (CI): 30.8, 36.1) months, a total of 127 patients with 605 pulmonary nodules, all of whom had received local therapy and firstly achieved CSR or complete radiated/metabolic remission (CRR), were included in the analysis. A total of 102 patients with 525 nodules were initially diagnosed with resectable lung metastases, while 25 patients had 80 indeterminate nodules at presentation and relapsed with pulmonary metastases within 6 months after the completion of adjuvant chemotherapy.
Results
Eighty-eight of 127 (69.3%) patients had fewer than 5 nodules at the time of local therapy, with 48 of 127 (37.8%) located in the unilateral pleura. No patient underwent thoracotomy, and 42 of 127 patients (85 nodules) received video-assisted thoracoscopic surgery (VATS). In addition, 79 of 127 patients (520 nodules) received hypofractionated stereotactic body radiotherapy (RT), such as Gamma Knife radiosurgery or CyberKnife radiosurgery. The twelve-month event-free survival (EFS) (from local therapy to progression) rate of this entire study cohort was 35.6% (95% CI: 26.8%, 44.4%), without a significant difference between the two groups (44.7% for VATS vs. 28.4% for RT, P = 0.755). Radiation-induced pneumonitis was observed in 62 of 86 (72.1%) patients, with one patient (1/86, 1.2%) in grade 4.
Conclusions
Our past data showed a similar prognosis with the use of hypofractionated radiotherapy and VATS for the treatment of pulmonary metastasis and no inferiority to thoracotomy regarding historical outcomes. Currently, high-resolution chest computed tomography (CT) provides sufficient information on nodules, and less invasive modalities can thus be considered for treatment.
Impact of Capital Flow on Economic Growth in Ethiopia: Empirical evidence from (1980-2010) using ARDL Approach
Authors: Gashu Bewket Aschale 
Published: April 2021

Abstract
Evidence abound that some transitioning and developing countries are attracting large inflows of foreign capital that could engender economic growth or have destabilizing effects on their economies if not well managed. This has undoubtedly aroused anxiety over its potential effects on economic growth, the competitiveness of the export and external sectors viability. The study examines the impact of capital flow on economic growth in Ethiopia as well as the causal short-run and long-run relationship among the variables, using time series data from 1980–2010. Using the ARDL Approach, the result revealed that all the variables are statistically significant; which implies that the capital flow has an impact on economic growth in both short- and long-run dynamic equilibrium models. Additionally, VAR and Innovative Accounting Techniques approach to Granger causality analysis showed that there exists bidirectional causality between gross capital flow and economic growth. Consequently, these findings suggest that policy makers should critically understand, the nature, what drives the capital flows and the impact of its sudden surge or reversal on economy. Moreover, it is also recommended that government should continue to pursue trade and foreign exchange policies that would ensure competitiveness of the export sector viability and economic growth.