bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway
Authors: Zhang Guang-Yan , Chen Wei-Yong , Li Xiao-Bo , Ke Hua , Zhou Xue-Lin 
Published: September 2021

Abstract
Scutellarin plays an anti-tumor role in A549 lung cancer cells, but the underlying mechanism is unclear. In this study, scutellarin was used to treat A549 cells for 12, 24, and 48 h, followed by the addition of Tempo, a selective scavenger of mitochondrial reactive oxygen species (ROS) and SB431542, a transforming growth factor (TGF)-β1 receptor inhibitor. A dihydroethidium fluorescence probe was used to measure the intracellular ROS level, Cell Counting Kit-8 (CCK-8) was used to detect cell viability, and flow cytometry was performed to examine apoptosis. Western blots were used to detect the total protein level of TGF-β1, p-smad2, and cleaved caspase-3 in A549 cells. The results showed that scutellarin significantly inhibited cell viability and increased apoptosis. Scutellarin also promoted intracellular ROS production, TGF-β1/smad2 signaling pathway activation, and cleaved caspase-3 expression, which was partly reversed by Tempo. Moreover, scutellarin-induced intracellular ROS production and cleaved caspase-3 expression were inhibited by blocking the TGF-β1/smad2 pathway with SB431542. In conclusion, scutellarin promoted apoptosis and intracellular ROS accumulation, which could be abrogated by Tempo and SB431542 treatment in A549 cells. Our study indicated that scutellarin induced A549 cell apoptosis via the TGF-β1/smad2/ROS/caspase-3 pathway.
Evidence for bicomponent fibers: A review
Authors: Zhu Shufang , Meng Xin , Yan Xu , Chen Shaojuan 
Published: September 2021

AbstractRecently, bicomponent fibers have been attracting much attention due to their unique structural characteristics and properties. A common concern was how to characterize a bicomponent fiber. In this review, we generally summarized the classification, structural characteristics, preparation methods of the bicomponent fibers, and focused on the experimental evidence for the identification of bicomponent fibers. Finally, the main challenges and future perspectives of bicomponent fibers and their characterization are provided. We hope that this review will provide readers with a comprehensive understanding of the design and characterization of bicomponent fibers.
A note on special cubic fourfolds of small discriminants
Authors: Truong Hoang Le , Yen Hoang Ngoc 
Published: September 2021

Abstract
In this paper, our purpose is to give a characterization of the generic special cubic fourfold which contains a smooth rational surface of degree 9 not homologous to a complete intersection. As corollaries, we will give an explicit construction of families of smooth surfaces in generic special cubic fourfolds

X
∈

𝒞
δ

{X\in\mathcal{C}_{\delta}}

for

6
<
δ
≤
30

{6<\delta\leq 30}

and

δ
≡

0

(

mod
6

)

{\delta\equiv 0~{}(\bmod~{}6)}

. This applies in particular to give an explicit construction of two different liaison class of smooth surfaces in all such special cubic fourfolds with the prescribed invariants.
Optimization of heat transfer and pressure drop of the channel flow with baffle
Authors: Ghobadi Behzad , Kowsary Farshad , Veysi Farzad 
Published: September 2021

Abstract
In this article, the numerical analysis has been carried out to optimize heat transfer and pressure drop in the horizontal channel in the presence of a rectangular baffle and constant temperature in two-dimension. For this aim, the governing differential equation has been solved by computational fluid dynamics software. The Reynolds numbers are in the range of 2,000 < Re < 10,000 and the working fluid is water. While the periodic boundary condition has been applied at the inlet, outlet, and the channel wall, axisymmetric boundary condition has been used for channel axis. For modeling and optimizing the turbulence, k–ω SST model and genetic algorithm have been applied, respectively. The results illustrate that adding a rectangular baffle to the channel enhances heat transfer and pressure drop. Hence, the heat transfer performance factor along with maximum heat transfer and minimum pressure drop has been investigated and the effective geometrical parameters have been introduced. As can be seen, there is an inverse relationship between baffle step and both heat transfer and pressure drop so that for p/d equal to 0.5, 1, and 1.25, the percentage of increase in Nusselt number is 141, 124, and 120% comparing to a simple channel and the increase in friction factor is 5.5, 5, and 4.25 times, respectively. The results of modeling confirm the increase in heat transfer performance and friction factor in the baffle with more height. For instance, when the Reynolds number and height are 5,000 and 3 mm, the Nusselt number and friction factor have been increased by 35% and 2.5 times, respectively. However, for baffle with 4 mm height, the increase in the Nusselt number and friction factor is 68% and 5.57 times, respectively. It is also demonstrated that by increasing Reynolds number, the maximum heat transfer performance has been decreased which is proportional to the increase in p/d and h/d. Moreover, the maximum heat transfer performance in 2,000 Reynolds number is 1.5 proportional to p/d of 0.61 and h/d of 0.36, while for 10,000 Reynolds number, its value is 1.19 in high p/d of 0.93 and h/d of 0.15. The approaches of the present study can be used for optimizing heat transfer performance where geometrical dimensions are not accessible or the rectangular baffle has been applied for heat transfer enhancement.
Genotype and phenotypic spectrum of vitamin D dependent rickets type 1A: our experience and systematic review
Authors: Dodamani Manjunath Havalappa , Sehemby Manjeetkaur , Memon Saba Samad , Sarathi Vijaya , Lila Anurag R. , Chapla Aaron , Bhandare Vishwambhar Vishnu , Patil Virendra A. , Shah Nalini S. , Thomas Nihal , Kunwar Ambarish , Bandgar Tushar R. 
Published: September 2021

Abstract

Background
Vitamin D dependent rickets type 1 (VDDR1) is a rare disease due to pathogenic variants in 1-α hydroxylase gene. We describe our experience with systematic review of world literature to describe phenotype and genotype.

Methods
Seven patients from six unrelated families with genetically proven VDDR1 from our cohort and 165 probands from systematic review were analyzed retrospectively. The clinical features, biochemistry, genetics, management, and long-term outcome were retrieved.

Results
In our cohort, the median age at presentation and diagnosis was 11(4–18) and 40(30–240) months. The delayed diagnoses were due to misdiagnoses as renal tubular acidosis and hypophosphatemic rickets. Four had hypocalcemic seizures in infancy whereas all had rickets by 2 years. All patients had biochemical response to calcitriol, however two patients diagnosed post-puberty had persistent deformity. Genetic analysis revealed two novel (p.Met260Arg, p.Arg453Leu) and a recurring variant (p.Phe443Profs*24). Systematic review showed that seizures as most common presentation in infancy, whereas delayed motor milestones and deformities after infancy. Diagnosis was delayed in 27 patients. Patients with unsatisfactory response despite compliance were >12 years at treatment initiation. Inappropriately normal 1,25(OH)2D may be present, however suppressed ratio of 1,25(OH)2 D/25(OH)D may provide a clue to diagnosis. Various region specific and hot-spot recurrent variants are described. Patients with truncating variants had higher daily calcitriol requirement and greatly suppressed ratio of 1,25(OH)2D/25(OH)D.

Conclusion
Delayed diagnosis may lead to permanent short stature and deformities. Truncating variants tend to have severe disease as compared to non-truncating variants. Diagnostic accuracy of 1,25(OH)2 D/25(OH)D ratio needs further validation.
Triple-Endobutton and clavicular hook: A propensity score matching analysis
Authors: Zhang Sujie , Zhang Haojie , Wang Jiabo , Ma Xuehai , Gu Shaohua 
Published: September 2021

Abstract
We retrospectively analyzed the clinical data of 635 patients with acute acromioclavicular dislocation, who underwent surgery in our hospital between May 2014 and June 2020. Patients were divided into group A (clavicular hook plate) and group B (Triple-Endobutton plates via double-incision). The propensity score analysis using one to one match was performed for comparisons. We obtained 292 matched patients’ data. The matched preoperative clinical characteristics were a balance between the two groups. All clinical parameters showed insignificant differences (P > 0.05). Compared with group A, group B has longer operative time (P < 0.001) and more blood loss (P < 0.001); however, the mean incision length (P < 0.001) and length of hospitalization (P < 0.001) were shorter in group B than in the group A. The mean VAS in group B were significantly lower than in group A at each time point (P < 0.001), and the UCLA shoulder score was higher in the group B. The CMS scores were also higher in group B than in group A, including before removal and 12 weeks after removal (P < 0.001). The clinical efficacy of the double-incision Triple-Endobutton plate is better than the clavicular hook plate technology, and achieves anatomical reduction by reconstructing coracoclavicular ligament.
Crystal structure of (8R,10R,14R,Z)-12-hydroxy-2-((6-methoxypyridin-2-yl)methylene)-4,4,8,10,14-pentamethyl-17-((R)-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-3H-cyclopenta[a]phenanthren-3-one–water (2/1), C37H56NO4.5
Authors: Luo Qin , Meng Qing-Guo , Hou Gui-Ge , Jiang Sheng , Jin Yong-Sheng , Gao Yue 
Published: September 2021

Abstract
C37H56NO4.5, tetragonal, P41212/c (no. 92), a = 10.4368(10) Å, b = 10.4268(10) Å, c = 61.5166(11) Å, V = 6700.80(18) Å3, Z = 8, R

gt
(F) = 0.0557, wR

ref
(F
2) = 0.1350, T = 100 K.
The crystal structure of bis(6-phenylpyridine-2-carboxylate-κ2
N,O)-(2,2′-bipyridine-κ2
N,N′)zinc(II) monohydrate, C34H26N4O5Zn
Authors: Wang Li-Hua , Wang Zi-Jian , Ouyang Jian , Tai Xi-Shi 
Published: September 2021

Abstract
C34H26N4O5Zn, monoclinic, C2/c (no. 15), a = 29.3891(18) Å, b = 10.3260(5) Å, c = 19.9101(11) Å, V = 5783.1(6) Å3, Z = 8, R

gt
(F) = 0.0334, wR
ref(F
2) = 0.0759, T = 199.99(10) K.
Crystal structure of dichlorido-bis(4-chlorophenyl-κC
1)(2,2′-bipyridyl-κ
2
N,N′)tin(IV), C22H16Cl4N2Sn
Authors: Lo Kong Mun , Lee See Mun , Tiekink Edward R. T. 
Published: September 2021

Abstract
C22H16Cl4N2Sn, monoclinic, P21/n (no. 14), a = 10.0393(1) Å, b = 14.4490(2) Å, c = 14.1502(2) Å, β = 92.846(1)°, V = 2050.07(5) Å3, Z = 4, R

gt
(F) = 0.0224, wR

ref
(F
2) = 0.0590, T = 100 K.
Jewish Nietzscheanism
Authors: Holub Robert C. 
Published: September 2021

Abstract
Jewish Nietzscheans have traditionally shied away from any detailed examination of Nietzsche’s comments on contemporary Jewry or the Jewish religion. Scholars who have examined Jewish Nietzscheans have therefore sought to connect Nietzsche with some dimension of Jewish thought through similarities in views between Nietzsche and the Jewish intellectuals who were purportedly influenced by him. The two books under consideration in this essay strain to find solid connections between Nietzsche’s philosophy and the writings of eminent Jewish writers. Daniel Rynhold and Michael Harris examine how selected Nietzschean concepts can also be found in the work of the noted Jewish thinker Rabbi Joseph Soloveitchik. David Ohana, by contrast, examines a variety of Jewish writers who at some point exhibited an enthusiasm for Nietzsche, ranging from Hebrew scholars and translators to German-Jewish intellectuals. Both books suffer from many of the shortcomings of general Nietzschean influence studies: there is often no sound philological evidence of influence, or the “connection” is so general that it is difficult to see Nietzsche as the source of influence, or the alleged influence was of short duration, and it is difficult to understand what remains Nietzschean in the individual influenced.
Die Wahrheit des fiktionalen Mythos
Authors: Döhn Raphael 
Published: September 2021

Zusammenfassung
Dieser Beitrag fokussiert den von Hans Jonas in Der Gottesbegriff nach Auschwitz. Eine jüdische Stimme als Antwort auf die Theodizeefrage skizzierten Mythos und setzt ihn in Beziehung zu Fiktionalitätsdiskursen. An die Darstellung und Erläuterung des Mythos schließen sich Ausführungen zu den ihm zugrundeliegenden Quellen (u. a. Gnosis, Kabbala, Hegel) sowie zu Jonas’ eigenen Reflexionen zur Textgattung und zu den Kernaussagen des Mythos an. Nach einer christlich-theologischen Würdigung der jonasschen Religionsphilosophie wird der Mythos unter Bezugnahme auf Fiktionalitätsdiskurse betrachtet und auf Berührungspunkte mit jüdischen, christlichen und gnostischen Weltentstehungs- und Welterklärungserzählungen aufmerksam gemacht.
Reading Confessions of the Flesh as the Second Volume of the History of Sexuality
Authors: Rolfsen Raag 
Published: September 2021

Summary
In this article, I propose a different reading of Foucault’s newly published work than suggested by the publishers and in initial reviews. I question the claim that it represents the fourth volume of the History of Sexuality and rather propose to regard it as an intended second volume. Comparing Foucault’s final plan of publication of the series with the background and stated purpose of Les aveux de la chair, I hold that it is part of a different philosophical project than volumes two and three. Foucault wrote Les aveux de la chair to explore the roots of modern power in the experiences that early Christianity occasioned. This makes the work relevant for current theology and the philosophy of religion.
Kearns texture parameters, mechanical properties and damageability of titanium sheet after alternating bending
Authors: Usov V.V. , Shkatulyak N.M. , Savchuk O.S. , Rybak N.I. 
Published: September 2021

This work aims to determine the Kearns texture parameters and evaluate on their basis the elastic moduli, mechanical properties (ultimate tensile strength, conditional yield stress), as well as damageability parameters of the sheets commercial titanium (CT-grade 1: 0.04% Fe; 0.015% C; 0.05% N 0.05% c; 0.009% H) as delivered after rolling and annealing at 840°C (original sheet) and further alternating bending (AB) in the amount of 0.5; 1, 3 and 5 cycles. Damageability parameters characterizing damage accumulation were determined from the elastic modulus change after the above-mentioned number of AB cycles relative to the values ​​of the elastic modulus in different directions of the original sheet of the studied titanium. The elastic constants of the single crystal and the Kearns texture parameters were used to estimate the elastic modulus in the rolling direction (RD) and transverse direction (TD) of the original sheet, and sheets after an above number of AB cycles. The deviation of the calculated and experimental values ​​of the elastic modulus did not exceed 5%. The deviation of the calculated and experimental values of the ultimate tensile strength and yield stress in the RD and TD both in the initial state and after the corresponding number cycles of the AB did not exceed 10%.
Early-Onset Sepsis Among Very Preterm Infants
Authors: Flannery Dustin D. , Edwards Erika M. , Puopolo Karen M. , Horbar Jeffrey D. 
Published: September 2021

OBJECTIVES
To determine the epidemiology and microbiology of early-onset sepsis (EOS) among very preterm infants using a nationally representative cohort from academic and community hospitals to inform empirical antibiotic guidance, highlight risk factors for infection, and aid in prognostication for infected infants.

METHODS
Prospective observational study of very preterm infants born weighing 401 to 1500 g or at 22 to 29 weeks’ gestational age from January 2018 to December 2019 in 753 Vermont Oxford Network centers. EOS was defined as a culture-confirmed bacterial infection of the blood or cerebrospinal fluid in the 3 days after birth. Demographics, clinical characteristics, and outcomes were compared between infants with and without EOS.

RESULTS
Of 84 333 included infants, 1139 had EOS for an incidence rate of 13.5 per 1000 very preterm births (99% confidence interval [CI] 12.5–14.6). Escherichia coli (538 of 1158; 46.5%) and group B Streptococcus (218 of 1158; 18.8%) were the most common pathogens. Infected infants had longer lengths of stay (median 92 vs 66 days) and lower rates of survival (67.5% vs 90.4%; adjusted risk ratio 0.82 [95% CI 0.79–0.85]) and of survival without morbidity (26.1% vs 59.4%; adjusted risk ratio 0.66 [95% CI 0.60–0.72]).

CONCLUSIONS
In a nationally representative sample of very preterm infants with EOS from 2018 to 2019, approximately one-third of isolates were neither group B Streptococcus nor E coli. Three-quarters of all infected infants either died or survived with a major medical morbidity. The profoundly negative impact of EOS on very preterm infants highlights the need for novel preventive strategies.
Development and validation of LC-MS/MS method for determination of plasma apixaban
Authors: Dzudovic Jelena , Sakac Milkica Crevar , Antunovic Marko , Repic Aleksandra , Obradovic Slobodan , Djordjevic Snezana , Savic Jelena , Dzudovic Boris 
Published: September 2021

Abstract
Oral anticoagulants are a group of drugs used for the prevention and treatment of venous thrombosis and venous thromboembolism. For the last ten years, direct oral anticoagulants (DOAC) have been available and are equally effective, but significantly safer than vitamin K antagonists. In the case of an overdose, their most important side effect is still bleeding. Due to their widespread use, as well as increased toxicological importance there is a need to develop an analytical method for the determination of DOAC in biological material.
The aim of this paper was to establish a method for the quantification of apixaban as one of the representatives of DOAC. The methodology of the study included the measurement of apixaban in the plasma of patients treated in the intensive care unit. Plasma apixaban concentrations were determined by LC-MS/MS technique using carbamazepine as an internal standard. Obtained validation parameters indicate that the introduced method is sensitive, reliable, precise and accurate. Using this method, apixaban can be quickly and easily detected and quantified in plasma in patients who are suspected of overdosing with this drug.
Impossible Presuppositions. On factivity, focus, and triviality
Authors: Verdecchia Matías 
Published: September 2021

This paper analyzes certain restrictions on polarity focus marking in clauses embedded under emotive factive predicates. It argues that these restrictions arise because this configuration leads to a systematic presupposition failure in virtue of its focus value, which I call impossible presupposition. The main argument offered here supporting this approach involves some novel asymmetries with factive clauses in predicate doubling construction in Spanish. From a theoretical perspective, the larger agenda of this article is to provide new evidence that certain types of ungrammaticality are due to semantic-pragmatic factors, namely, logical triviality.
Features of coping behavior at prisoners in a pre-trial detention center
Authors: Petrova Nataliia N. , Kurapova Ekaterina Yu. , Khomenko Alexander E. 
Published: September 2021

Aim. To study the coping behavior of persons in a pre-trial detention facility in order to identify groups at risk of psychological maladjustment.
Methods. The survey method and the Heims methodology for diagnosing of the coping strategies were used.
Results. It was found that non-adaptive and relatively adaptive behavioral and cognitive coping strategies prevail over adaptive ones in all the comparison groups. In all groups, the greatest number of maladaptive coping was found in the emotional sphere. The presence of adaptive cognitive coping is associated with a negative attitude to ones offense, maladaptability of behavioral coping is associated with aggression, and emotional coping is associated with the use of psychoactive substances. The adaptability of behavioral strategies is associated with the presence of experience of the institutional confinement. It is established that newly arrived prisoners are at risk of psychological maladjustment, and prisoners who are held in common prisons rooms have high indices of coping adaptability.
Conclusions. The surveyed comparison groups differ in the targets of psychological correction. The risk groups for developing mental maladjustment are newly arrived prisoners.
Finite-Difference Modeling and Characteristics Analysis of Love Waves in Anisotropic-Viscoelastic Media
Authors: Yuan Shichuan , Zhang Zhenguo , Ren Hengxin , Zhang Wei , Song Xianhai , Chen Xiaofei 
Published: September 2021

ABSTRACTIn this study, the characteristics of Love waves in viscoelastic vertical transversely isotropic layered media are investigated by finite-difference numerical modeling. The accuracy of the modeling scheme is tested against the theoretical seismograms of isotropic-elastic and isotropic-viscoelastic media. The correctness of the modeling results is verified by the theoretical phase-velocity dispersion curves of Love waves in isotropic or anisotropic elastic or viscoelastic media. In two-layer half-space models, the effects of velocity anisotropy, viscoelasticity, and attenuation anisotropy of media on Love waves are studied in detail by comparing the modeling results obtained for anisotropic-elastic, isotropic-viscoelastic, and anisotropic-viscoelastic media with those obtained for isotropic-elastic media. Then, Love waves in three typical four-layer half-space models are simulated to further analyze the characteristics of Love waves in anisotropic-viscoelastic layered media. The results show that Love waves propagating in anisotropic-viscoelastic media are affected by both the anisotropy and viscoelasticity of media. The velocity anisotropy of media causes substantial changes in the values and distribution range of phase velocities of Love waves. The viscoelasticity of media leads to the amplitude attenuation and phase velocity dispersion of Love waves, and these effects increase with decreasing quality factors. The attenuation anisotropy of media indicates that the viscoelasticity degree of media is direction dependent. Comparisons of phase velocity ratios suggest that the change degree of Love-wave phase velocities due to viscoelasticity is much less than that caused by velocity anisotropy.
Associação entre estresse ocupacional, hipertensão e obesidade em docentes da Rede Federal de Ensino
Authors: Montenegro Neto Asdrúbal Nóbrega , Portela Alyne Da Silva , Braga Fernanda Lira , Amâncio Neto Raimundo , Montenegro Ramon Cunha 
Published: September 2021

<p><span>Trata-se de um estudo de corte transversal, descritivo e analítico, com abordagem quantitativa. Este trabalho teve como objetivos: determinar o nível de estresse ocupacional, a frequência de obesidade e hipertensão arterial, além de identificar a existência de associação entre estresse ocupacional, hipertensão arterial e obesidade, em professores vinculados ao Instituto Federal de Educação, Ciência e Tecnologia da Paraíba, Campus Sousa. Foi realizada aplicação de um questionário para avaliação de dados sociodemográficos e ocupacionais e outro de avaliação de estresse ocupacional, com a utilização da Escala de Estresse no Trabalho (EET). Posteriormente, foi realizada uma Avaliação Antropométrica e verificou-se a pressão arterial. Na Avaliação Antropométrica, mediu-se o Índice de Massa Corporal (IMC), a Circunferência Abdominal, a Circunferência da Cintura, a Circunferência do Quadril e a relação Cintura-Quadril (RCQ). Os resultados demonstram uma alta frequência de indivíduos, 50%, com estresse ocupacional alto, e uma alta frequência de sobrepeso, 43,33%. 27,77% apresentam obesidade e 28,88% apresentam pressão arterial elevada. Contudo, não foi constatada uma associação estatisticamente significativa entre estresse alto, obesidade, sobrepeso ou pressão arterial elevada. Verificou-se ainda, que, nesta população, o estresse está relacionado à preocupação com a ética e a igualdade no trabalho.</span></p>