bluuebunny/crossref_metadata_2025_split huggingface dataset:
The search for dipeptidyl peptidase iv (DPP4) inhibitors for the treatment of type 2 diabetes: an in-silico study
Authors: Ruslin  , Al-Febriana K , Usman I , Arba M 
Published: May 2021

Abstract
Dipeptidyl Peptidase IV (DPP4) enzyme is a dissolved plasma enzyme found in the intestinal, kidney and liver capillaries that degrade the Glucagon Like Peptide-1 (GLP-1), which is crucial in regulating blood glucose levels. Thus, DPP4 inhibition was considered as an important strategy to combat diabetes. In this research, a pharmacophore modeling and molecular docking was conducted to identify the potential hits of DPP4 inhibitors. The pharmacophore features consisted of three hydrogen bonds acceptors and one positive ion with Area Under Curve of Receiver Operating Characteristic (AUC-ROC) were 0.72 and GH score of 0.592. Screening on the ZINC database resulted in 1151 hit molecules, in which all molecules were subjected to molecular docking to explore their binding interactions. The binding energies of all ligand were between -5.08 and -10.56 kcal/mol, in which four hit molecules, i.e. The four best hit molecules in term of binding orientation and binding energy were Lig_1418/zinc215387739, Lig_37/zinc7983247, Lig_1432/zinc100998449, and Lig_1037/zinc104157322, exhibited better affinities than that of cognate ligand (ABT341, E=-9.98 kcal/mol), which indicated their potentials as novel DPP4 inhibitors.
Synthesis of graphene-MnxOy nanocomposite as electrode sensors of profenofos
Authors: Azis Thamrin , Agusu La , Kadir L.A. , Rahmad Muh. Resky , A. Tenri L.O 
Published: May 2021

Abstract
Synthesis and characterization of of Graphene-Mnnanocomposites as Pesticide sensor electrodes have been carried out. This study aims to determine the method for synthesizing and characterizing the products of Graphene-Mnnanocomposite synthesis. Modification of Graphene using Mn nanoparticles for profenophos analysis with cyclic voltammetry. This research using with the Modified Hummers method and the liquid phase adsorption method followed by hydrothermal. Characterization of Graphene-Mn oxide nanocomposites are displayed using XRD, SEM-EDX and FTIR. The XRD results showed that there are peaks of Mn3O4 (30.57, 44.39), MnO2 (34.14), and MnO (39.85, 57.85, 68.94). SEM-EDX analysis reveals the surface of graphene sheets containing aggregates in shape small particles attached to graphene sheets. The results of the EDX analysis consisted of Mn 6.26%, C 53.60% and O. 15.45%. The FTIR test indicates the presence of Mn-O bonds in wave number 615.29 cm-1 and other functional groups, such as O-H, C-O, C = C, and C-H. Electrodes with the best composition at pH 6 will be used to detect pesticides profenofos with the Cyclic Voltammetry (CV) method at a scate rate of 0.05 V / s. The detection limit obtained from graphane-Mn measurements on profenofos is 0,000667 M. and the repeatability of graphane-Mn performance is 0.0131. The age of Graphene-Mn electrodes in analyzing profenofos pesticides is 17 days. The selectivity test using Pb (NO3)2 0.1M and Phenol 0.1M disrupting compounds occurred in a negative direction.
The antibacterial inhibition test of gonad sea urchin (diadema setosum) against the growth of staphylococcus aureus
Authors: Irma  , Tee Selfyana Austin , Fithria  , Muhammad Ilyas Y. 
Published: May 2021

AbstractA The sea urchin is sea animal the rich in vitamin A, vitamin B complex and minerals to the smooth functioning of the nervous system and the metabolism of the human body. Gonad sea urchin contains flavonoids, steroids, triterpenoids, and saponins. This research was conducted to determine inhibition of antibacterial ointment sea urchin gonads against Staphylococcus aureus. The type of research conducted is experimental. This research used a cylinder cup method to measure inhibition zone of gonad sea urchin gonad. After incubation for 24 hours, measured inhibitory zone diameter around the cylinder cup. The results showed that the sea urchin gonads ointment have inhibitory effect on the growth of Staphylococcus aureus bacteria with broad average inhibition zone produced at a concentration of 2% at 2.47 mm, 4% of 1.62 mm, and a concentration of 6% has inhibitory zone Of 1.12 mm, and a positive control of 11.55 mm and the negative control does not provide a drag zone. Based on the ANOVA test results can be concluded that the F test = 0.691 <F table = 3.48 to 0.05, this means significant treatment 3 repetitions in each of the samples showed that there was no significant difference for F count is smaller than F table.
Ethanol and Sugar Production from Sorghum (Sorghum bicolor) Starch at Varying Acidity
Authors: Hadiyanti Nugraheni , Putu Ngurah Wijaya I , Saptorini  , Kustiani Edy 
Published: May 2021

Abstract
Sorghum (Sorghum bicolor), in addition to producing foodstuffs, feed, industrial use, is also potential for ethanol production. Sorghum is also a potential developed because it has a complete adaptation power in marginal land and other non-productive lands. The use of sorghum starch for ethanol production is a renewable fuel alternative and friendly for the environment. The aim of the research was to study the fermentation of sorghum starch into simple sugars and ethanol at varying acidity (pH). The study is experimental research with two treatment factors: pH (4; 6; 7; 8; 9; 10) and sugar levels. Data were collected and analyzed with simple and multiple linear regression analyses. The result showed that the pH treatment applied to influence the enzyme fermentation of sorghum starch. The conclusion of the study is the optimum pH of amylase enzyme activity in fermenting sorghum starch into glucose is pH 8. The relationship between the amount of alcohol, sugar, and pH is very strong at 95.1%. Multiple regression equations to explain the relationship of the three variables that the amount of alcohol (Y) produced in sorghum starch fermentation can be estimated additive by the amount of sugar formed (X1) and pH (X2).
Precipitation Method in Calcium Phosphat Synthesis from Blood Clamshells (Anadara Granosa)
Authors: Nurma Wahyusi K , Karunia N , Satrya M 
Published: May 2021

Abstract
Sources of calcium phosphate can be produced from materials containing calcium carbonate (CaCO3). These materials are usually found in clamshells, eggshells and limestone. Calcium phosphate can be produced by chemical precipitation by reacting calcium carbonate (CaCO3) from a material containing CaCO3 with HCl and then reacting again with Na2HPO4 and calcium phosphate Ca3(PO4)2 is obtained. In this study raw materials used for blood clamshells waste. Precipitation is a method which results in the formation of solids in solution or in other solids during chemical reactions. From the results of XRF analysis it can be seen that the best results entered in the classification of calcium phosphate are at pH 8 with a stirring time of 3 hours and pH 9 with a stirring time of 4 hours there is a Ca/P value of 1.5. At the Ca/P value it forms Tricalcium Phosphate. There are 3 types of Tricalcium Phosphate which are α, β and amorphous. It can be concluded that the longer the stirring time and the pH value increase, the Ca / P value also increases. To form TCP (Tricalcium Phosphate).
Antioxidant Potential of the Shell of Razor Clams (Solen spp) in Antidiabetic Mellitus Type II Therapy
Authors: Anggarani Mirwa Adiprahara , Purnama Erlix Rakhmad , Dalilah Aziz Jihan Shofwatul Islam 
Published: May 2021

Abstract
Razor clams (Solen spp) are one type of bivalves found in Madura waters and suggested to have antioxidant bioactive compounds. This research was conducted to determine the chemical compounds and antioxidant activity as well as testing blood sugar levels on mice that are conditioned to suffer from diabetes mellitus. The extraction method used is stratified by using three solvents which have different polarity. The test being done was phytochemistry tests to determine the bioactive compounds contained in the shell of razor clams, DPPH method to determine antioxidant activity, and blood sugar test in mice. The crude extracts of the shell of razor clams is contained alkaloid and saponins The highest antioxidant activity (IC50) was found from the shell of razor clams extracted eith ethanol was 489.56 ppm. The results of the blood sugar test showed that the addition/consumption of antioxidant extract of razor clams of 0.0063g/20g body weight (BW) was able to reduce blood sugar levels of mices with diabetes mellitus type 2.
Study on Flood Simulation of Tallo Watershed, Makassar City, South Sulawesi Province
Authors: Musliadi  , Chaerul M , Gusty S 
Published: May 2021

Abstract
Tallo watershed has a length of 70 km, its area width is 407.00 ¬¬km2, the river upstream or downstream is at an altitude of ± 1,100 m above sea level located on Mount Kaliapolompo in which the overall length of the river in Tallo watershed totaling ± 131.50 km2. The research objective was to analyze the effect of five-year flood discharge and tidal changes on the inundation area and flood depth in Tallo watershed. The method of rainfall analysis used the Log Pearson type III method where the flow is considered to be two horizontal dimensions with even velocity at each depth. A five-year period with a discharge value of 127.64 m3/s will statistically reoccur every five years with an estimated chance of occurrence of 0.2 or 20% for each year referred to in a 5-year review cycle. The results of the simulation were then known that the five-year flood discharge resulted in flooding with a depth of 0-3 meters from the maximum tide condition (HWSL), and an inundation area of 31.91 km2 inundated the Tallo District, Tamalanrea District, Panakukang District, West Biringkanaya District and northern Manggala District. These areas are located on the left and right of the Tallo River with an altitude between 0 and 2 meters above sea level.
A general framework of covid-19 model with control strategies: the application of large-scale social restrictions, self-quarantine, and immune system improvement in Surabaya, Indonesia
Authors: Artiono Rudianto , Yunianti Dwi Nur , Prawoto Budi Priyo , Astuti Yuliani Puji 
Published: May 2021

Abstract
A covid-19 is a virus disease of worldwide importance which spread not only in a small country such as Mongolia but also in a large country like the United State. It is caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and well known as droplet-borne disease. The droplets containing coronavirus are spread through the air within a meter and deposited on the mucous membranes of suscpetible person. The aim of this study was to produce a general framework model of corona virus disease with the application of large-scale social restriction, self-quarantine and immune system improvement as control strategies to reduce the spread of the disease. This study was conducted in Surabaya, Indonesia with a total of 299 positive patients infected with covid-19 until the fourth week of April, 2020. The transmission routes of the disease had been constructed based on the real problem. Therefore, human population have been divided into some sub-population based on the characteritics of disease symptoms. The spread of covid-19 have been formulated mathematically by using compartment model. Stability analysis had been done for a free disease equilbrium and an endemic equilibrium. Moreover, numerical simulation were also provided to quantify the disease dynamics.
Regional Overview of Food Security from Two Dimensions: Availability and Access to Food, East Java Province
Authors: Lisanty Nina , Andajani Wiwiek , Pamudjiati Agustia Dwi , Artini Widi 
Published: May 2021

Abstract
Food security has always been a topic of keen interest to policy-makers, practitioners, and academics worldwide. In the operational sense, food security concerns the availability, accessibility, and stability of its procurement. The leading indicators of food security at the household level access (physical and economic) to food, food availability and risks associated with food access and availability. A study was conducted by utilizing data from several government institutions to examine the level of regional and household food security of East Java Province. The result showed that the food security level of East Java Province has increased between 2010 and 2017, mainly because of improvements in several indicators of food security and nutrition. However, two main challenges require serious attention, namely: a) increasing economic access to food, mainly through increased investment and infrastructure and b) addressing increased vulnerability to the risk of climate change. In conclusion, this paper discusses information and suggestions to improve the food security level in the province, including approaching programs and policies related to the issues.
Factors Affecting Rice Production
Authors: Ginting Nina Maksimiliana , Andari Gardis 
Published: May 2021

Abstract
This study aims to look at the factors that affect rice production. This research was conducted in Tanah Miring District, Merauke Regency. Site selection is done deliberately (purposive). Sampling using Purposive methods as many as 88 farmers. The data used in this study include primary data and secondary data. Data were analyzed using Multiple Linear Regression Analysis. The coefficient of determination (R2) is 0.955. This coefficient of determination shows that rice production (Y) can be explained by seed variables (X1), fertilizer (X2), pesticides (X3), and labor (X4) by 95.5% while the remaining 4.5% is influenced by factors others are not included in the equation. Significant value of F equal to 0,000, namely seed variables (X1), fertilizer (X2), pesticides (X3), and labor (X4), simultaneously have a significant effect on rice production variable (Y). Partially, seeds and pesticides affect rice production while fertilizer and labor do not affect rice production. The classic assumption test shows that there are no multicollinearity, heteroscedasticity symptoms and normally distributed regression models.
Performance Study of Regional Water Supply Company of Ternate City, North Maluku
Authors: Nagu Nani , Ahadian Edward R , Latif Lita A. , Fabanyo H 
Published: May 2021

Abstract
Regional Water Supply Company (RWSC) of Ternate City is a company managed by the local government which in its operation needs to prioritize the fulfillment of clean water for communities. Therefore the services of RWSC should based on the standards of quality service provided by the National Agency for the Improvement of Drinking Water Supply System. On the other side, the demand for clean water supply and services is increasing every year. This is caused by an increase in population and the development of cities or service areas relating to the improvement of the socio-economic. The purpose of this study is to evaluate the performance of water supply service providers in Ternate City. Data analysis based on the guidelines from the National Agency for the Improvement of Drinking Water Supply System involves several indicators such as the financial aspects, service aspects, operational aspects, and aspects of human resources. The result shows that the score of the financial reaches 0.92, the service aspect 0.88, the operational aspect 0.88, and the human resource aspect 0.52. These results show that the performance of Regional Water Supply Company (RWSC) of Ternate City achieves score 3.2 and it indicates that the performance of Regional Water Supply Company (RWSC) of Ternate City in the healthy category.
Preliminary Study of Digital Manufacturing Requirement for Kampus Merdeka Apprenticeship Program
Authors: Rachmat  , Nugraha Syaiful , Prihandoko LA , Marsujitullah  , Suwarjono  
Published: May 2021

Abstract
Students are allowed to take courses outside campus in the Kampus Merdeka program. In this regard, students need to be equipped with competence related to digital industries’ needs, especially for computer science students. The purpose of this research is to conduct a preliminary study of the abilities needed by the student to execute the Kampus Merdeka program base on stakeholders’ perspectives, who specifically are digital manufacturing in Papua. This research is a quantitative study that employs a survey strategy. Respondents came from various fields related to digital manufacturing, including banks, government offices, private companies, and digital start-ups. The online questionnaire was distributed, and 100 respondents gave responses related to the abilities students must possess for digital manufacturing field working. The findings of this study underline several essential abilities, including industry 4.0 framework knowledge, digital usage skills, and information communication technology (ICT) skills. The findings of this study contribute to a better understanding of the technical capabilities required by stakeholders. The results of this study can be developed into a policy of aligning the capabilities of students with digital manufacturing needs.
Analysis of resources allocation on passenger ship reparation project using work breakdown structure method in pt. xyz
Authors: Rivanda Fristy Novia , As’adi M , Montreano D 
Published: May 2021

Abstract
Each project generally conducts planning and makes a project schedule, when the project should start and completed, how the project will be carried out, and how to provide its resources. Resources are one of the factors that affect the project’s limited amount of profit. So we need a careful and good planning with limited resources in implementing the project in order to use resources efficiently. The purpose of this study is to evaluate the reparation project planning so that there are no more delays in the project by detailing the work package through the Work Breakdown Structure (WBS) method, which in previous studies showed that there was a delay of 4 days using the S-curve. The study was carried out on the KMP (Passenger Motor Ship) repair project at the shipyard PT. XYZ The type of research method used is descriptive qualitative case study approach and purposive sampling. Research methods are using Fault Tree Analysis (FTA) to determine the triggering factors for delays, Critical Path Method (CPM) to determine critical paths, Work Breakdown Structure (WBS) to determine the division of work package levels, WBS dictionary for job identification and resource requirements. Obtained a percentage of 91.3%. Due to the result of work package similarities is x ≥ 75%, there is a tendency for the work package of the WMP KMP Dictionary to further the KMP Repair Project.
Islamic Banking Third-party Funds Grouping uses the Data Mining Clustering
Authors: Hidayat S , Irwansyah R 
Published: May 2021

Abstract
Islamic banking as an intermediary institution (intermediary) between people with excess funds and people who lack funds has a very important influence on the Indonesian economy. In this study, the third-party funds discussed were third-party funds of Islamic banking. The purpose of this study is to analyze the grouping of Islamic banking third-party funds on Indonesia’s economic growth over the past 11 years, from 2009 to 2019 using the K-means algorithm. The data of this study uses time-series data from Islamic banking statistics, namely data on third-party funds for Islamic banking financing sourced from the official website of the Financial Services Authority. The findings of this analysis are in the context of a clustering of Islamic banking third-party funds containing 2 clusters: low (C1) and high (C2). The results obtained are there are 7 data with low clusters and 4 data with high clusters. The results of calculations carried out manually and testing using Rapid Miner, produce the same data grouping.
Description of Probability and Randomized Events Literacy for Statistics Student at Universitas Negeri Makassar
Authors: Tiro M A , Aswi  , Sudarmin  
Published: May 2021

Abstract
The concept of probability and randomized events is the main basis of statistics. Thus, literacy of probability and randomized events is a basis of statistical literacy. This study aimed to describe and assess the literacy of probability and randomized events for students of the statistics department of the first (2013) and the second (2014) batch at Universitas Negeri Makassar. Statistical literacy is defined in four indicators namely understanding the concept; the ability to apply; the ability to calculate; and interpretation skills of probability and randomized events. The approach used for the analysis of this survey data were descriptive quantitative and classification. Classification analysis was used to determine problems classification faced by students in probability and randomized events literacy. A confirmatory factor analysis was used to see the validity of the construct operational definitions of the variables. This study found that the level of probability and randomized events literacy achieved by statistics students at Universitas Negeri Makassar is categorized medium, pointing to the need for increased learning strategies that emphasize the four basic competencies.
Global Stability Analysis of Dengue Transmission Model with Awareness, Vector Control and Time Delays
Authors: De Lara-Tuprio Elvira P. , Teng Timothy Robin Y. , Macalalag Jay Michael R. 
Published: May 2021

Abstract
In this paper, a mathematical model for a single-strain dengue virus transmission, incorporating vector control, disease awareness of susceptible humans, and both the latent delays for human and mosquitoes, is proposed and studied. The global stability properties of disease-free equilibrium and endemic equilibrium are completely established through Lyapunov functionals and LaSalle’s invariance principle. The global dynamics of the equilibrium points are characterized by the value of basic reproductive number R
0. If R
0
< 1, then the disease-free equilibrium is globally asymptotically stable. If R
0
> 1, then the disease-free equilibrium is unstable, and the endemic equilibrium exists which is globally asymptotically stable. Lastly, this paper presents numerical simulations and possible recommendations for future works.
A diffusion and osmosis system with bounded nonlinearity
Authors: Suratman Dede , Soeharyadi Yudi , Cahyono Edi , Arbi Lukman H. 
Published: May 2021

AbstractA diffusion and osmosis system of ordinary differential equation is considered. The system may represent migration of finite particle among finite places. Such system in the linear form yields a solution in the form of matrix exponential. In this paper, a bounded nonlinear forcing to the system is considered. Although it is bounded, the nonlinear affected so much to the solution. Numerical simulation of some two-dimensional examples are presented. Understanding the diffusion and osmosis system will be important for studying migration people among towns, cities or countries.
A survey to estimate the proportion of Southeast Sulawesi elementary school students reading fluently
Authors: Wibawa Gusti N.A. , Somayasa Wayan , Yahya Irma , Hidayat Ahid , Abapihi Bahriddin 
Published: May 2021

Abstract
We conducted a survey to estimate the proportion of elementary school students in Southeast Sulawesi who have been able to read fluently while sitting at second grade. The information is needed to contribute to the policy towards enhancement of elementary student ability to read in their early stage of schools. A two-stage cluster sampling method had been applied in order to maintain the representativeness of selected samples over the whole population. At the first stage, we randomly chose the districts and, then, randomly selected the sub-districts. Finally, all elementary schools in each selected sub-district were taken as well as all their second grade students as the sampling units. Doing these, wegot 230 respondents randomly selected from 78 elementary schools of 20 sub-districts in all 6 selected districts or regencies. Based on the selected samples, it is approximately only 32% of students were able to read fluently, while the rest of them were unable or less abilityto read.