bluuebunny/crossref_metadata_2025_split huggingface dataset:
A deliberate language policy or a perceived lack of agency: Heritage language maintenance in the Polish community in Melbourne
Authors: Romanowski Piotr 
Published: March 2021

Aims: By applying the tripartite framework of family language policy, this study seeks to gain insight into heritage language maintenance of Polish families in Melbourne. To this end, an integrative investigation of family language policy encapsulating the heritage language perceptions, practices and management will be employed. Methodology: Based on the data collected through the online questionnaire supplemented with in-depth interviews, quantitative and qualitative analyses have been conducted to obtain a sociolinguistic picture of the convoluted dependencies. Data and analysis: The interviews were recorded, transcribed verbatim and coded according to the grounded theory approach. The recurrent themes were noted. The existing social patterns were conceptualised through the process of constant comparison. The excerpts selected for analysis illustrate how critical have been the informants’ beliefs and practices concerning heritage language maintenance. Findings and conclusions: The data analyses of the researched families disclose a wide range of practices where certain discrepancies are observed between declarations and the actual language behaviours. It also emerges that without parents’ reinforcement and establishing the heritage language as a default means of communication at home, children suffer from lower productive skills. Originality: This paper delves into how Polish is maintained as a heritage language by the second generation of Polish-speaking immigrants. It explores the Polish community, one of the well-established yet understudied groups that make up multicultural Australia. It unfolds an account of the dynamics of family language policy, illustrating how they are constantly negotiated, contested and formed by parents. Significance/implications: The findings contribute to the ongoing discussion of language policies and heritage language maintenance by demonstrating that the hardship and distress resulting from heritage language acquisition as well as language maintenance are incumbent primarily on family language policy. The researched group is an average-size immigrant community situated in the context with limited institutional support resolving down to Polish Saturday schools.
The ‘tipping point’: Exploring the factors associated with entry into residential care for people with dementia in Western Australia
Authors: McGrath Thomas , Blundell Barbara , Morrisby Claire 
Published: March 2021

Background People with dementia usually prefer to live in the community. Research is needed to identify the ‘tipping point’ for residential care entry and to highlight how people with dementia can be supported to remain at home as long as possible. Few previous studies have examined caregivers’ perceptions and explanations for the reasons people with dementia need to enter residential care in Australia. Aim To explore the factors contributing to people with dementia entering residential care in Perth, Western Australia, from the perspectives of informal carers and care staff. Method This phenomenological study used purposive sampling to recruit informal and formal caregivers of people with dementia. Semi-structured in-depth interviews were conducted with 13 family carers and 11 home care staff. Data were thematically analysed to identify individual, carer and contextual factors that impact on residential care entry. Findings The majority of participants identified a combination of factors as the ‘tipping point’ to residential care entry; a few also identified the cause as a sudden event or specific issue. Factors identified included deterioration related to worsening cognition, changed behaviours and a decline in the performance of activities of daily living; co-occurring health conditions; safety concerns; carer no longer able to meet care needs; impact of providing support becoming too much for the informal carer; lack of family or social support and needing assistance from services that were unavailable or inaccessible. Factors assisting people with dementia to remain living at home longer were family and social support, formal services and dog ownership. Conclusion This study identified individual, carer and contextual factors that contribute to people with dementia entering residential care in Australia. The ‘tipping point’ was recognised as when the needs of a person with dementia outweigh the capacity of their informal and formal carers, services and supports to care for them.
A qualitative evaluation of the impact of a Good Life Club on people living with dementia and care partners
Authors: Morris Lydia , Innes Anthea , Smith Sarah , Wilson Jack , Bushell Sophie , Wyatt Megan 
Published: March 2021

Background Research suggests there is a lack of post-diagnostic support to enable people living with dementia to fulfil social and active lives throughout their dementia journey. Gardening has been found to have many benefits for people living with dementia. Although such research is important, most research frames people with dementia as passive recipients of stimulation. Research into the impact of a community-based gardening group, where people living with dementia are active in the development of an outdoor space, is underdeveloped. Knowledge about the impact of participating in such groups is also sparse. The Good Life Club (GLC) was co-developed and evaluated to respond to these gaps. Objectives The primary aim of this article is to present the findings regarding the impact of attending the GLC on the self-reported well-being for people living with dementia and care partners. Methods Qualitative data were collected via 22 semi-structured interviews. Fourteen interviews were conducted before the GLC and eight after the GLC. Thematic analysis was used to analyse data. Dementia Care Mapping data were collected to supplement the interview data. Findings Four key themes were identified. The first was that participants considered having active participation in social life to be a key aspect of living a good life. The second was that the way that the GLC was set up and delivered gave the participants ownership of the GLC and within this they felt able to contribute. The third was the importance of social connectedness and peer support to the well-being of both people living with dementia and care partners. Fourth, positive mood and well-being was directly experienced through gardening. Conclusions The combination of long-term investment of time and energy to the GLC, ongoing friendships and in-session autonomy act as key ingredients in creating a group that is relaxed, full of humour and highly valued.
Efficacy and safety of flow diverters in posterior circulation aneurysms and comparison with their efficacy in anterior circulation aneurysms: A systematic review and meta-analysis
Authors: Abdel-Tawab Mohamed , Abdeltawab Ahmed K , Abdelmonem Mohamed , Moubark Mahmoud A , Taha Mohamed AH , Morsy Abdalla , Bessar Ahmed Awad , Ahmed Ebada Mahmoud 
Published: March 2021

Purpose We aimed to assess the efficacy and safety of flow-diverter stents (FDs) in the management of posterior circulation cerebral aneurysms and compare FD efficacy between anterior and posterior circulation aneurysms. Methods We searched the PubMed, Scopus, Cochrane, and Web of Science databases for relevant studies through March 2020. Studies assessing FDs for posterior circulation aneurysms that included ≥20 treated aneurysms were included. Moreover, the studies compared FD efficacy between anterior and posterior circulation aneurysms were included. Data regarding angiographic aneurysmal occlusion, procedural complications, mortality, and morbidity were extracted and pooled in a random-effects meta-analysis model. Results Fourteen studies with a total of 659 patients and 676 posterior circulation aneurysms were included. The pooled rate of aneurysmal occlusion at long-term angiographic follow-up was 78% [95% confidence interval (CI), 71–85]. The pooled rates of intraparenchymal hemorrhage, ischemia, and procedure-related mortality and neurological morbidity were 2%, 8%, 7%, and 6%, respectively. Complete occlusion occurred in 82.4% of the posterior circulation aneurysm subgroup and 77.5% of the anterior circulation aneurysm subgroup. The difference was not significant (relative risk 1.01; 95% CI, 0.86–1.19; p = 0.91). Regression analysis showed that elderly patients and females had higher morbidity. Conclusion Posterior circulation aneurysms can be effectively treated with FDs with comparable occlusion rates to those in anterior circulation aneurysms. However, periprocedural complications are not negligible.
Diagnosing small fiber neuropathy in clinical practice: a deep phenotyping study
Authors: Egenolf Nadine , Altenschildesche Caren Meyer zu , Kreß Luisa , Eggermann Katja , Namer Barbara , Gross Franziska , Klitsch Alexander , Malzacher Tobias , Kampik Daniel , Malik Rayaz A. , Kurth Ingo , Sommer Claudia , Üçeyler Nurcan 
Published: March 2021

Background and aims: Small fiber neuropathy (SFN) is increasingly suspected in patients with pain of uncertain origin, and making the diagnosis remains a challenge lacking a diagnostic gold standard. Methods: In this case–control study, we prospectively recruited 86 patients with a medical history and clinical phenotype suggestive of SFN. Patients underwent neurological examination, quantitative sensory testing (QST), and distal and proximal skin punch biopsy, and were tested for pain-associated gene loci. Fifty-five of these patients additionally underwent pain-related evoked potentials (PREP), corneal confocal microscopy (CCM), and a quantitative sudomotor axon reflex test (QSART). Results: Abnormal distal intraepidermal nerve fiber density (IENFD) (60/86, 70%) and neurological examination (53/86, 62%) most frequently reflected small fiber disease. Adding CCM and/or PREP further increased the number of patients with small fiber impairment to 47/55 (85%). Genetic testing revealed potentially pathogenic gene variants in 14/86 (16%) index patients. QST, QSART, and proximal IENFD were of lower impact. Conclusion: We propose to diagnose SFN primarily based on the results of neurological examination and distal IENFD, with more detailed phenotyping in specialized centers.
Validation of an educational game to promote cardiovascular health in children
Authors: Chaves Costa Francisca Bertilia , Catrib Ana Maria Fontenelle , de Almeida Lana Paula Crivelaro Monteiro , de Souza Araújo Santos Zélia Maria , de Oliveira Branco July Grassiely , Bruno da Silva Carlos Antonio 
Published: March 2021

Objective: The aim of this study was to validate the content and appearance of an educational game for children aged 7 to 10 years, focusing mainly on cardiovascular health promotion. Method: The study used methodological research, with a quantitative approach. The validation process included the participation of 17 specialists in children and/or cardiovascular health. A concordance index of at least 0.80 was considered for content validation and 0.75 for the appearance of the proposed educational material. Results: The proposal of the educational game was considered valid, through some suggestions, in view of the purpose of sensitizing children in relation to the promotion of cardiovascular health while still in childhood. Final considerations: As a relevant factor in the use of games as strategies to improve health education, we emphasize that the participant is the active agent and the protagonist of the health-disease process.
Simulation of Cerebrospinal Fluid Leak Repair Using a 3-Dimensional Printed Model
Authors: Masalha Muhamed A. , VanKoevering Kyle K. , Latif Omar S. , Powell Allison R. , Zhang Ashley , Hod Keren H. , Prevedello Daniel M. , Carrau Ricardo L. 
Published: March 2021

Background Acquiring proficiency for the repair of a cerebrospinal fluid (CSF) leak is challenging in great part due to its relative rarity, which offers a finite number of training opportunities. Objective The purpose of this study was to evaluates the use of a 3-dimensional (3D) printed, anatomically accurate model to simulate CSF leak closure. Methods Volunteer participants completed two simulation sessions. Questionnaires to assess their professional qualifications and a standardized 5-point Likert scale to estimate the level of confidence, were completed before and after each session. Participants were also queried on the overall educational utility of the simulation. Results Thirteen otolaryngologists and 11 neurosurgeons, met the inclusion criteria. A successful repair of the CSF leak was achieved by 20/24 (83.33%), and 24/24 (100%) during the first and second simulation sessions respectively (average time 04:04 ± 1.39 and 02:10 ± 01:11). Time-to-close-the-CSF-leak during the second session was significantly shorter than the first (p < 0.001). Confidence scores increased across the training sessions (3.3 ± 1.0, before the simulation, 3.7 ± 0.6 after the first simulation, and 4.2 ± 0.4 after the second simulation; p < 0.001). All participants reported an increase in confidence and believed that the model represented a valuable training tool. Conclusions Despite significant differences with varying clinical scenarios, 3D printed models for cerebrospinal leak repair offer a feasible simulation for the training of residents and novice surgeons outside the constrictions of a clinical environment.
A Novel Medial Malleolar Osteotomy Technique for the Treatment of Osteochondral Lesions of the Talus
Authors: Hu Yong , Yue Cheng , Li Xiucun , Li ZhengXun , Zhou Dongsheng , Xu Hailin , Zhang Ning 
Published: March 2021

Background: The current techniques for medial malleolar osteotomy may lead to posterior tibial tendon injury and have a high rate of malunion. Purpose: To describe a novel partial step-cut medial malleolar osteotomy technique and evaluate its technical feasibility and its advantages compared with traditional methods. Study Design: Case series; Level of evidence, 4. Methods: The novel technique consisted of osteotomy of the anterior one-third to two-thirds of the medial malleolus. A total of 19 ankles (18 patients) with osteochondral lesions of the talus underwent the novel osteotomy technique before osteochondral reconstruction. All patients were evaluated for more than 2 years. Radiographs were analyzed for postoperative displacement and malunion, and postoperative ankle function was evaluated according to the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scale and the visual analog scale (VAS) for pain. Results: The partial step-cut osteotomy technique was able to provide adequate intra-articular exposure without disturbing the posterior tibial tendon. The 19 ankles healed at a mean of 7.3 ± 1.5 weeks (range, 6-12 weeks). There was slight incongruence in 4 ankles, with a displacement of 1.0 ± 0.1 mm proximally and 0.3 ± 0.1 mm medially. The mean postoperative AOFAS and VAS scores improved compared with preoperatively, from 54.2 ± 12.1 to 84.6 ± 6.6 and from 6.4 ± 1.0 to 1.8 ± 1.3, respectively ( P < .001 for both). No intraoperative tendon injuries were observed. Conclusion: Results indicated that partial step-cut osteotomy is a reliable and effective method for providing enough exposure, avoiding displacement after reduction, and not disturbing the anatomic structures behind the medial malleolus.
Characterization of dual nano-size effects of ACC-cellulose nanofibrils on crystallization behavior of hydrophilic poly(vinyl alcohol)
Authors: Ishikawa Gento , Kondo Tetsuo 
Published: March 2021

AbstractThis study attempts to clarify thermodynamic quantification on interaction between poly(vinyl alcohol) (PVA) and wood-derived cellulose nanofibrils (CNFs) obtained by aqueous counter collision (ACC) method. Aqueous mixtures of PVA/ACC-CNFs with various fiber widths were cast as the target materials. The interfacial interactions between the two components were characterized through thermodynamic evaluation of the crystalline PVA component as a probe in the cast mixture. As the result, surface properties of the ACC-CNFs found to reflect on the crystallization behavior of the interacted PVA component, resulting in dual nano-size effects of either diluent or nucleating agent. Melting point depression behaviors of the PVA component indicated that ACC-CNFs with thinner widths induced nucleation effects on PVA crystallization, whereas ACC-CNFs with ca. 100 nm in width encouraged diluent effects on PVA components. It is noted that this trend found to be reverse to the case for PVA/ACC-CNFs of bacterial nanocellulose previously reported.
ATAV: a comprehensive platform for population-scale genomic analyses
Authors: Ren Zhong , Povysil Gundula , Hostyk Joseph A. , Cui Hongzhu , Bhardwaj Nitin , Goldstein David B. 
Published: March 2021

Abstract
Background
A common approach for sequencing studies is to do joint-calling and store variants of all samples in a single file. If new samples are continually added or controls are re-used for several studies, the cost and time required to perform joint-calling for each analysis can become prohibitive.

Results
We present ATAV, an analysis platform for large-scale whole-exome and whole-genome sequencing projects. ATAV stores variant and per site coverage data for all samples in a centralized database, which is efficiently queried by ATAV to support diagnostic analyses for trios and singletons, as well as rare-variant collapsing analyses for finding disease associations in complex diseases. Runtime logs ensure full reproducibility and the modularized ATAV framework makes it extensible to continuous development. Besides helping with the identification of disease-causing variants for a range of diseases, ATAV has also enabled the discovery of disease-genes by rare-variant collapsing on datasets containing more than 20,000 samples. Analyses to date have been performed on data of more than 110,000 individuals demonstrating the scalability of the framework.
To allow users to easily access variant-level data directly from the database, we provide a web-based interface, the ATAV data browser (http://atavdb.org/). Through this browser, summary-level data for more than 40,000 samples can be queried by the general public representing a mix of cases and controls of diverse ancestries. Users have access to phenotype categories of variant carriers, as well as predicted ancestry, gender, and quality metrics. In contrast to many other platforms, the data browser is able to show data of newly-added samples in real-time and therefore evolves rapidly as more and more samples are sequenced.

Conclusions
Through ATAV, users have public access to one of the largest variant databases for patients sequenced at a tertiary care center and can look up any genes or variants of interest. Additionally, since the entire code is freely available on GitHub, ATAV can easily be deployed by other groups that wish to build their own platform, database, and user interface.
Long-term dynamic compression enhancement TGF-β3-induced chondrogenesis in bovine stem cells: a gene expression analysis
Authors: Chen Jishizhan , Chen Lidan , Hua Jia , Song Wenhui 
Published: March 2021

Abstract
Background
Bioengineering has demonstrated the potential of utilising mesenchymal stem cells (MSCs), growth factors, and mechanical stimuli to treat cartilage defects. However, the underlying genes and pathways are largely unclear. This is the first study on screening and identifying the hub genes involved in mechanically enhanced chondrogenesis and their potential molecular mechanisms.

Methods
The datasets were downloaded from the Gene Expression Omnibus (GEO) database and contain six transforming growth factor-beta-3 (TGF-β3) induced bovine bone marrow-derived MSCs specimens and six TGF-β3/dynamic-compression-induced specimens at day 42. Screening differentially expressed genes (DEGs) was performed and then analysed via bioinformatics methods. The Database for Annotation, Visualisation, and Integrated Discovery (DAVID) online analysis was utilised to obtain the Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment. The protein-protein interaction (PPI) network of the DEGs was constructed based on data from the STRING database and visualised through the Cytoscape software. The functional modules were extracted from the PPI network for further analysis.

Results
The top 10 hub genes ranked by their connection degrees were IL6, UBE2C, TOP2A, MCM4, PLK2, SMC2, BMP2, LMO7, TRIM36, and MAPK8. Multiple signalling pathways (including the PI3K-Akt signalling pathway, the toll-like receptor signalling pathway, the TNF signalling pathway, and the MAPK pathway) may impact the sensation, transduction, and reaction of external mechanical stimuli.

Conclusions
This study provides a theoretical finding showing that gene UBE2C, IL6, and MAPK8, and multiple signalling pathways may play pivotal roles in dynamic compression-enhanced chondrogenesis.
Takotsubo cardiomyopathy complicating acute pancreatitis: a case report
Authors: Yeh John , Carroll James 
Published: March 2021

Abstract
Background
Acute pancreatitis as a trigger of Takotsubo cardiomyopathy has been infrequently described in the literature. Misdiagnosis of this phenomenon can often occur due to overlap in symptomology, particularly in those outside of the usual patient demographic.

Case presentation
A 27-year-old man with a history of alcohol abuse presented with epigastric and chest pain. Electrocardiography showed ischemic changes, and laboratory workup revealed elevated lipase and troponin. He was diagnosed with acute pancreatitis and managed presumptively as acute coronary syndrome. Subsequent coronary angiography was negative for obstructive coronary artery disease, and left ventriculography demonstrated basal hyperkinesis and apical akinesis, characteristic of Takotsubo cardiomyopathy.

Conclusions
Takotsubo cardiomyopathy is a rare complication of acute pancreatitis. Increased awareness of this phenomenon is required to prevent delays in diagnosis and avoid unnecessary interventions and complications.