bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of an Intervention on the Medical, Dental and Health Sciences Students About Interprofessional Education and Collaboration; A Quasi-experimental Study
Authors: Guraya Salman Yousuf , David Leena R. , Hashir Shermin , Mousa Noha A. , Albayatti Saad W. , Hasswan Ahmed Abd Alrazzak , Kaouas Mujtaba 
Published: February 2021

Abstract
BackgroundInterprofessional education and collaboration (IPEC) fosters patient safety and encompasses integration, communication, mutual trust and shared decision-making. Despite its crucial role, the IPEC has not gained its anticipated popularity. This study aims to determine the impact of an educational intervention about IPEC on medical, dental and health sciences students in the University of Sharjah. MethodsThis quasi-experimental research was conducted in three phases; a pre-intervention phase where the Readiness for Interprofessional Learning Scale (RIPLS) inventory was administered online to the medical, dental and health sciences students of the University of Sharjah; an intervention phase where an online workshop was organized via Microsoft Teams®; and a post-intervention phase where RIPLS was used to gather the students’ attitudes towards IPEC. The independent t test was used to compare the responses between genders and junior and senior students. A paired sample t test was used to determine the impact of the intervention on the students’ understandings. ResultsOut of 800 students invited to participate in this study, 530 students responded to the pre-intervention RIPLS survey. A comparison of the pre-post intervention for the RIPLS subscales of teamwork and collaboration, professional identification, and professional roles showed a significant improvement of the students’ attitudes with p-values 0.03, 0.00 and 0.00, respectively. All workshop moderators scored a median of 4 or 5 to the essential elements of IPEC during intervention except for a median of 3 for group dynamics.ConclusionIn this study, the present data derived from the application of a brief educational intervention highlight the challenges of IPEC implementation in the medical field. However, the demonstrated student readiness and positive impact of the intervention support the development of a structured curriculum to enhance the receptiveness and application of IPEC in clinical training and practice.
Trends from the Field: Impact of Telecommuting on Clinician Absenteeism in Primary Care
Authors: Caron Aleece , Bauchens Kim , Russo Francesca , Teng Kathryn 
Published: February 2021

Abstract
Provider burnout is a challenge faced by most large healthcare systems. Like many hospital systems, our system has struggled with burnout and turnover in our primary care clinician workforce. In March 2020 due to COVID, our large safety-net system had to rapidly transform from primarily in-person care to primarily telehealth visits. We sought to understand how this change in our model of healthcare delivery to enable telecommuting would affect absenteeism among primary care clinicians. We transitioned all 192 primary care nurse practitioners and physicians in the fields of Internal medicine, Family medicine, Medicine-Pediatrics, and Geriatrics across our health system to predominately a remote telehealth schedule. During March-May 2019, the percentage of telehealth visits was less than 1%. The shift to telehealth Mid-March 2020, shows an increase in telehealth by 35.9%. Telehealth visit volumes shifted to 87.4% for the month of April 2020 while leveling to 58.4% in May 2020 as patients needed services that required in person visits. Our analysis shows that the average decrease in call off rate from March- May 2019 compared to 2020 was 40.8%. Telehealth includes telecommunication through a variety of platforms. For primary care clinicians, telehealth provides an additional tool to manage panels of patients with potentially greater ease and efficiency. We know that clinicians want to provide high quality care for their patients, and they want some flexibility and autonomy to do so. Telecommuting may offer those benefits to providers.
Does Treatment Impact on the Quality of Life in Breast Cancer Patients? A Comparative Study Between Treatments
Authors: Hermoso Lorena Gutiérrez , Furlong Lilian Velasco , Román Sofía Sánchez , Pérez Elisabeth Berzal , Castillejos Natasha Alcocer , Friedman Paulina Quiroz 
Published: February 2021

Abstract
BackgroundBreast cancer involves complicated emotional processes. One of the factors that impacts the psychological symptoms and decreases QoL is the side effects of treatment. This study compared the psychological and physical impacts of women with early stages of breast cancer (stages I to III) being treated with chemotherapy versus hormone therapy. This study also intended to identify which symptoms could predict a decrease in quality of life (QoL) and functionality according to the treatment. MethodThis study had a cross-sectional design. The participant sample comprised 129 women with breast cancer (63 receiving chemotherapy and 66 hormone therapy). ResultsSignificant differences were found in groups regarding QoL, functionality, symptomatology (fatigue and nausea), coping strategies, and alexithymia. Furthermore, in patients receiving chemotherapy, both symptomatologies explained the variance in QoL, but only fatigue explained role functioning. For patients receiving hormone therapy, fatigue was the symptom that explained the variance for both QoL and role functioning. ConclusionsThe results confirmed that women undergoing chemotherapy are more physically and psychologically impacted. For both treatments, fatigue was a crucial symptom that affected QoL and role functioning. These results show the need to help women alleviate their psychological symptoms because they can affect their physical condition.
TRIM27 interacts with Iκbα to promote the growth of human renal cancer cells through regulating the NF-κB pathway
Authors: Xiao Chengwu , Zhang Wei , Hua Meimian , Chen Huan , Yang Bin , Wang Ye , Yang Qing 
Published: February 2021

Abstract
Background: The tripartite motif (TRIM) family proteins exhibit oncogenic roles in various cancers. The roles of TRIM27, a member of the TRIM super family, in renal cell carcinoma (RCC) remained unexplored. In the current study, we aimed to investigate the clinical impact and roles of TRIM27 in the development of RCC. Methods: The mRNA levels of TRIM27 and Kaplan–Meier survival of RCC were analyzed from The Cancer Genome Atlas database. Real-time PCR and Western blotting were used to measure the mRNA and protein levels of TRIM27 both in vivo and in vitro. siRNA and TRIM27 were exogenously overexpressed in RCC cell lines to manipulate TRIM27 expression. Results: We discovered that TRIM27 was elevated in RCC patients, and the expression of TRIM27 was closely correlated with poor prognosis. The loss of function and gain of function results illustrated that TRIM27 promotes cell proliferation and inhibits apoptosis in RCC cell lines. Furthermore, TRIM27 expression was positively associated with NF-κB expression in patients with RCC. Blocking the activity of NF-κB attenuated the TRIM27-mediated enhancement of proliferation and inhibition of apoptosis. TRIM27 directly interacted with Iκbα, an inhibitor of NF-κB, to promote its ubiquitination, and the inhibitory effects of TRIM27 on Iκbα led to NF-κB activation.Conclusions: Our results suggest that TRIM27 exhibits an oncogenic role in RCC by regulating NF-κB signaling. TRIM27 serves as a specific prognostic indicator for RCC, and strategies targeting the suppression of TRIM27 function may shed light on future therapeutic approaches.
Pediatric Preseptal and Orbital Cellulitis: Analysis of Clinical, Laboratory and Imaging Findings of 123 Cases.
Authors: Bülbül Lida , Saglam Neslihan Ozkul , Elitok Gizem Kara , Yazıcı Zahide Mine , Hatipoglu Nevin , Hatipoglu Sami , Palabıyık Figen Bakırtaş , Yigit Ulviye , Bülbül Ali 
Published: February 2021

Abstract
Background: To compare the clinical and laboratory characteristics and imaging methods of patients diagnosed with preseptal cellulitis and orbital cellulitis in the pediatric age group. Methods: The study was designed retrospectively and the medical records of all patients who were hospitalized with the diagnosis of preseptal cellulitis and orbital cellulitis were reviewed. The findings of preseptal cellulitis and orbital cellulitis groups were compared. The risk factors for the development of orbital involvement were analyzed. Results: A total of 123 patients were included, 90.2% with preseptal cellulitis and 9.8% with cellulitis. The male gender ratio was 60.2% and the mean age was 72±43 months. While all patients had eyelid swelling and redness 20.3% had fever. Ocular involvement was 51.2% in the right eye and 4.9% in both eyes. The most common predisposing factor was rhinosinusitis (56.1%). Radiological imaging (Computed tomography/magnetic resonance imaging) was performed in 83.7% of the patients. Subperiostal abscess were detected in 7 cases (5.6%) which three of the cases were managed surgically and four were treated with medically. The levels of c-reactive protein were significantly higher in patients with orbital involvement (p:0.033) but there was no difference between the presence of fever, leukocyte and platelet values. Conclusions: Rhinosinusitis was the most common predisposing factor in the development of preseptal cellulitis and orbital cellulitis. Orbital involvement was present in 9.8% of the patients. It was determined that high c-reactive protein value could be used to predict orbital involvement. Keywords: Childhood, preseptal cellulit, rhinosinusit, orbital cellulit, subperiostal abscess.
Predictive Value of Small Dense Low-density Lipoprotein Cholesterol for Cardiovascular Events in Chinese Elder Diabetes Mellitus Patients
Authors: Xu Li , Chen Xu , Lu Jingfen , Xu Yan , Yang Honglin , Zhou Xuewen , Xu Jianhong , shen Hao 
Published: February 2021

Abstract
BackgroundAs a subcomponent of lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C) has been suggested to be a better predictor of cardiovascular diseases (CVD). The aim of this research was to evaluate the predictive value of the sdLDL-C in cardiovascular events (CVs) in Chinese elder type 2 diabetes mellitus (DM) patients.MethodsA total of 386 consecutive type 2 DM patients were included into this study during December 2014 to December 2016. The serum sdLDL-C level of each subject was measured by homogeneous method. During a period of 48-month’s follow-up, the occurrence of CVs and associated clinical information were recorded. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serum sdLDL-C to occurrence of major CVs.ResultsA total of 92 CVs occurred during the study period. The ROC curve analysis manifested that sdLDL-C in the study population had a matchable discriminatory power (AUC for sdLDL-C was 0.7366, P = 0.003). In addition, Kaplan-Meier event-free survival curves displayed an obvious increase of CVs risk for sdLDL‐C≧26 mg/dL (log-rank = 9.10，P = 0.003). This phenomenon had analogous results in patients who received statins at baseline (log rank = 7.336，P = 0.007). Cox regression analysis revealed that the increase in HbA1c, glucose, LDL-C, sdLDL-C, non-HDL-C and ApoB and the decrease in ApoAI were obviously interrelated with heightened CVs risk . Multiple Cox regression demonstrated that the increase of sdLDL-C and HbA1c was significantly correlated with CVs. The results of the study indicated that high sdLDL-C level (＞10 mg/dL) was a risk factor for CVs in the multivariate model (HR 1.281, 95% CI 1.225-16.032; P<0.01).ConclusionsdLDL-C level could be an effective predictor in predicting the future CVs for Chinese elder type 2 DM patients with dyslipidemia.
Enhanced Saccharfication of Pomegranate Peel by Trichoderma Reesei and Statiscal Optimization of Medium Composition by Response Surface Methodology
Authors: PANCHAMOORTHY P.SARAVANAN , Kannan R.Rajesh 
Published: February 2021

Abstract
In this work, pomegranate peels (PPs) otherwise considered as waste is used as substrates for producing cellulase. Pomegranate peel was employed as a carbon source to be produced of cellulase in submerged state fermentation (SmF). Statistical experimental designs were employed to screen the nutrients and optimize the media composition for cellulase production by Trichoderma reesei. Nine nutrients were selected by the preliminary screening of medium component production by plackett –burman design (PBD) technique. Four nutrients have been found to be important for cellulase production and optimized by central component design (CCD). The best media component for submerged fermentation of cellulase using pomegranate peel were avicel– 24.812 g/l, KH2PO4 – 4.626 g/l, soybean cake flour – 20.7 g/l and MnSO4.H2O-1.036 g/l. Under these optimum conditions, the production of cellulase was found to be 9.3 IU/mL. The optimum factors acquired from the statistical model were further confirmed using the experimental results.
Antibacterial Mechanisms of Orostachys Cartilaginous Cell Cultures: Effect on Cell Permeability and Respiratory Metabolism of Bacillis Subtilis
Authors: Liu Y. X. , Jiang X. L. , Xu Y. N. , Piao X. C. , Lian Mei-Lan 
Published: February 2021

Abstract
Orostachys cartilaginous of Crassulaceae family is a plant native to the Changbai Mountain area, China. Although O. cartilaginous has various medicinal values, its product development and production are restricted by the insufficient resource available. O. cartilaginous cell cultures possess an efficient antibacterial effect against Bacillis subtilis, but the underlying mechanism is not clear yet. Therefore, this study investigated the effects of extract from bioreactor cultured O. cartilaginous cells (OE) on B. subtilis cell permeability and respiratory metabolism to provide a reference for the further utilization of O. cartilaginous cell cultures. Results showed alkaline phosphatase activity, electrical conductivity, nucleic acid and protein contents in B. subtilis suspensions were significantly increased (p < 0.01) by OE treatment, indicating the occurrence of cell damage or increase in cell permeability. OE inhibited B. subtilis respiration, and the combination groups of OE+iodoacetic acid (IA) and OE+sodium phosphate (SP) showed low superposition rates (approximately 35%), revealing that OE likely affected IA- and SP-represented metabolic pathways. The activities of B. subtilis enzymes, specifically, hexokinase and pyruvate kinase in the Embden-Meyerhof (EMP) pathway and glucose-6-phosphate dehydrogenase in the pentose phosphate (HMP) pathway, decreased after OE treatment. This result proved that OE inhibited B. subtilis respiration by regulating the EMP and HMP pathways.
How well do international clinical guidelines on mental health and substance misuse address their coexistence? a systematic review of scope, quality and inclusivity
Authors: Alsuhaibani Ray , Smith Douglas Cary , Lowrie Richard , Aljhani Sumayah , Paudyal Vibhu 
Published: February 2021

Abstract
Objective: It is estimated that up to 75% of patients with severe mental illness (SMI) also have substance use disorder (SUD). The aim of this systematic review is to explore the scope, quality and inclusivity of international clinical guidelines on mental health and/or substance misuse in relation to diagnosis and treatment of such co-existing disorders and considerations for wider social and contextual factors in treatment recommendations.Method: A protocol (PROSPERO CRD42020187094) driven systematic review was conducted. A systematic search was undertaken using six databases including MEDLINE, Cochrane Library, EMBASE, PsychInfo from 2010 till June 2020; and webpages of guideline bodies and professional societies. Guideline quality was assessed based on ‘Appraisal of Guidelines for Research & Evaluation II’ (AGREE II) tool. Data was extracted using a pre-piloted structured data extraction form and synthesized narratively. Reporting was based on PRISMA guideline.Result: A total of 12,644 records were identified. Of these, 21 guidelines were included in this review. Three of the included guidelines were related to coexisting disorders, 11 related to SMI, and 7 guidelines were related to SUD. Seven (out of 18) single disorder guidelines did not adequately recommend the importance of diagnosis or treatment of concurrent disorders despite their high co-prevalence. The majority of the guidelines (n = 15) lacked recommendations for medicines optimisation in accordance with concurrent disorders (SMI or SUD) such as in the context of drug interactions. Social cause and consequence of dual diagnoses such as homelessness and safeguarding and associated referral pathways were sparsely mentioned.Conclusion: Despite very high co-prevalence, clinical guidelines for SUD or SMI tend to have limited considerations for coexisting disorders in diagnosis, treatment and management. There is a need to improve the scope, quality and inclusivity of guidelines to offer person-centred and integrated care.
Investigation of Optical, Structural and Electrical Properties of Heterostructure Fe2O3 Deposited by RF Magnetron Sputtering on ZnO Layer by Spray Pyrolysis
Authors: Sarıtaş Sevda , Çakıcı Tuba , Muğlu Günay Merhan , Yıldırım Muhammet 
Published: February 2021

Abstract
In this study, we, firstly, fabricated Fe 2 O 3 thin film recently promising to be used in spintronic technology by magnetron sputtering technique on ZnO thin film prepared by spray pyrolysis at 450 o C. The crystal structure, surface morphology and structure, chemical composition, optical and electronic properties, and electric properties of the Fe 2 O 3 /ZnO sample were performed by X-ray diffraction (XRD), scanning electron microscope (SEM) and atomic force microscope (AFM), energy-dispersive X-ray (EDX), ultraviolet-visible (UV-VIS) and Raman spectrometer, and Hall measurements, respectively. XRD measurements showed that Fe 2 O 3 and ZnO thin films have monoclinic and hexagonal crystal structures, respectively, and also both of them are polycrystalline. SEM images proved that there is a very good with the stoichiometric formation of ZnO nanocrystals of spherical shape and demonstrate aggregation of the particles and AFM images displays the distribution of flake-like of Fe 2 O 3 structure over the surface of ZnO. UV-VIS and Raman measurements revealed that the ZnO and Fe 2 O 3 /ZnO heterostructure band's band gap energy are 3.277 and 3.24 eV, respectively. Finally, the calculated values of electric conductivity, σ, electron density, n, and mobility of the electron, μ, using the data obtained from Hall measurements are 4.39x10 2 Ω -1 .m -1 , 6.88x10 21 m -3 and 3.99x10 -1 V -1 .m 2 . s, respectively.
Comparing formative and summative simulation-based assessment in undergraduate nursing students: nursing competency acquisition and clinical simulation satisfaction
Authors: Arrogante Oscar , González-Romero Gracia María , López-Torre Eva María , Carrión-García Laura , Polo Alberto 
Published: February 2021

Abstract
BackgroundFormative and summative evaluation are widely employed in simulated-based assessment. The aims of our study were to evaluate the acquisition of nursing competencies through clinical simulation in undergraduate nursing students and to compare their satisfaction with this methodology using these two evaluation strategies.Methods218 undergraduate nursing students participated in a cross-sectional study, using a mixed-method. MAES© (self-learning methodology in simulated environments) sessions were developed to assess students by formative evaluation. Objective Structured Clinical Examination sessions were conducted to assess students by summative evaluation. Simulated scenarios recreated clinical cases of critical patients. Students´ performance in all simulated scenarios were assessed using checklists. A validated questionnaire was used to evaluate satisfaction with clinical simulation. Quantitative data were analysed using the IBM SPSS Statistics version 24.0 software, whereas qualitative data were analysed using the ATLAS-ti version 8.0 software.ResultsMost nursing students showed adequate clinical competence. Satisfaction with clinical simulation was higher when students were assessed using formative evaluation. The main students’ complaints with summative evaluation were related to reduced time for performing simulated scenarios and increased anxiety during their clinical performance.ConclusionThe best solution to reduce students’ complaints with summative evaluation is to orient them to the simulated environment. It should be recommended to combine both evaluation strategies in simulated-based assessment, providing students feedback in summative evaluation, as well as evaluating their achievement of learning outcomes in formative evaluation.
Assessment of Climate Change Impacts on Maize Production in Mali
Authors: SOUMAORO Tiémoko 
Published: February 2021

Abstract
This study examined the total, direct and indirect effects of climatic variables (temperature and rainfall) on crop yields maize in a given region and in neighbouring regions, through a spatial panel analysis of five administrative regions of Mali over a 30-year period (1988 - 2017). Our results show that temperature and rainfall have direct, indirect and total effects on maize yields. In other words, the effect on regions closely linked to the region where the change in temperature or rainfall occurred will be greater than the effect on more remote regions. In addition, the coefficient of variation of precipitation and the interaction between temperature and precipitation as well as the area sown all have negative impacts on maize yields. However, maize yields are negatively correlated with drought. This means that maize production in the local area is declining as a result of increased extreme weather events. Based on these findings, policy makers need to take into account that conditions in the surrounding areas can influence maize yields and that spillover effects differ between crop types. Investments in agricultural research and development should be encouraged to counteract the effects of climate change.
Defect-induced ferromagnetism in a S=1/2 quasi-one-dimensional Heisenberg antiferromagnetic chain compound
Authors: Wang Zhe , Hu Lin , Lin Langsheng , Han Yuyan , Hao Ning , Xu Jingtao , Chen Qianwang , Qu Zhe 
Published: February 2021

Abstract
We present evidences that defects in the spin S=1/2 Heisenberg antiferromagnetic chain (HAFC) compound can lead to ferromagnetism by studying the magnetic and thermal properties of the newly discovered quasi-one-dimensional (1D) metal-organic framework [CH 3 NH 3 ][Cu(HCOO) 3 ] (MACuF). Our findings suggest that the long-range ferromagnetic order at 3.7 K can be attributed to Cu 2+ ions from the 2D networks constructed by the endpoints of the broken chains. It is worth mentioning that the ferromagnetic saturation field is less than 5 Oe. In such a case, the intrinsic magnetism can emerge in this quasi-1D Heisenberg chain system at the background of the anti-ferromagnetism. This unusual ferromagnetism found in HAFC not only enriches magnetic features in the low-dimensional systems, but helps to understand some of the exotic magnetic phenomena in other real quasi-1D magnetic materials.