bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Two Vector Data-Prediction Model for Energy-Efficient Data Aggregation in Wireless Sensor Network
Authors: Jain Khushboo , Singh Akansha 
Published: August 2021

Abstract
Most ecological management applications use Wireless Sensor Networks (WSNs) to collect data regularly, with great temporal redundancy. As a result, a significant amount of energy is used transmitting redundant data, making it tremendously problematic to attain a satisfactory network lifetime, which is a bottleneck in enduring such environmental monitoring applications. A two-vector prediction model based on Normalized Quantile Regression (NQR) for Data Aggregation is proposed to proficiently accomplish energy reduction in synchronized data collecting cycles. The introduced NQR algorithm provides high-accuracy prediction. With accurate estimates, energy usage is reduced.Furthermore, it extends the network's lifetime. In intracluster transmissions, NQR uses a two-vector data-prediction algorithm to coordinate the anticipated sensor's reading and, as a result, minimize cumulative inefficiencies from unin-terrupted predictions. NQR algorithm can be integrated with both homogeneous and heterogeneous WSNs. When compared to existing methods, the suggested NQR methodology is shown to have high energy efficiency.The results show greater prediction accuracy, more positive predictions with high data quality, which help the network last longer.
Testing The Efficacy of a Couple-Focused, Tailored eHealth Intervention for Symptom Self-Management Among Men with Prostate Cancer and Their Partners: The Study Protocol
Authors: Song Lixin , Nielsen Matthew E. , Chen Ronald C. , Rini Christine , Keyserling Thomas C. , Idiagbonya Eno , Fuller Gail P. , Northouse Laurel , Palmer Mary H. , Tan Xianming 
Published: August 2021

Abstract
Background: Men with localized prostate cancer often experience urinary, sexual, bowel, and hormonal symptoms, general distress, pain, fatigue, and sleep disturbance. For men in an intimate relationship, these symptoms disrupt couples’ relationships and intimacy. The symptoms also reduce quality of life of both men and their partners, who are often their primary caregivers. Management of the negative effects of cancer and its treatment is a significantly under-addressed supportive care need for these men and their intimate partners. To address these unmet supportive care needs, our interdisciplinary team developed and pilot tested the usability and feasibility of an evidence-based, couple-focused, tailored eHealth intervention, “Prostate Cancer Education & Resources for Couples” (PERC). Based on the adapted stress and coping theoretical framework and developed with stakeholder involvement, PERC aims to improve quality of life for both men and their partners by enhancing their positive appraisals, self-efficacy, social support, and healthy behaviors for symptom management.Methods: We will test the efficacy of PERC using a population-based, geographically and demographically diverse cohort in a randomized controlled trial. Primary Aim: Assess if patients and partners receiving PERC will report greater improvement in their cancer-related quality of life scores than those in the control group (usual care plus the National Cancer Institute prostate cancer website) at 4, 8, and 12 months post-baseline. Secondary Aim: Test if patients and partners in PERC will report significantly more positive appraisals and higher levels of coping resources at follow-ups than those in the control group. Exploratory Aim: Determine if patient race and ethnicity, education, type of treatment, or couples’ relationship quality moderate the effects of PERC on patient and partner QOL at follow-ups..Discussion: This study will provide a novel model for self-managing chronic illness symptoms that impact couples’ relationships, intimacy, and quality of life. It addresses the National Institute of Nursing Research’s goal to develop and test new strategies for symptom self-management to help patients and caregivers better manage their illness and improve quality of life. It also responds to calls for programs from the Institute of Medicine and American Cancer Society to address treatment-related effects and improve survivors’ QOL..Trial registration: CT.gov ID: NCT03489057
Expression and Significance of miR-654-3p/ARL4C in Patients with Glioma
Authors: Gao Hua , Zhongjin Yang , Zhenye Li , Zhenzong Li 
Published: August 2021

Abstract
Background: ADP-ribosylation-like factor4C (ARL4C) is overexpressed in several cancer tissues and is involved in cancer development. Increasing evidence reveals that aberrant microRNAs (miRNAs) expression play a crucial role in the tumorigenesis of cancers. Nevertheless, the exact mechanism that regulates ARL4C expression in glioma has not been fully elucidated. The aim of this study was to investigate expression and significance of miR-654-3p/ARL4C in glioma.Methods: CGGA and TCGA databases were used to study the prognosis role of miR-654-3p, ARL4C and the relationship between ARL4C and pathological grade in gliomas. Real-time quantitative PCR was performed to detect the levels of miR-654-3p and ARL4C in glioma tissues. CCK-8 and colony formation experiments were used to observe the effects of miR-654-3p and ARL4C on the proliferation of U87 cells.Results: CGGA database and TCGA database both showed that the level of ARL4C was increased along with the WHO grades of glioma, and patients with high ARL4C had lower IDH mutation ratio, older age and poor overall survival (OS) compared with patients with low ARL4C. The clinical features in patients with high miR-654-3p showed the opposite trend compared with patients with high ARL4C. In vitro experiments showed that overexpression of ARL4C promoted cell proliferation in U87 cells. Dual-luciferase reporter gene assays showed that ARL4C was the target gene of miR-654-3p, and miR-654-3p mimics could inhibit the cell proliferation of U87 cells, and ARL4C partly counteracted the role of miR-654-3p in U87 cells.Conclusions: miR-654-3p/ARL4C is associated with pathological grade of glioma, and patients with high ARL4C or low miR-654-3p have shorter OS. miR-654-3p/ARL4C may serve as a prognostic factor in patients with glioma and new potential therapeutic target.
Modeling and Research of the Deformation Treatment Process of 585 Gold Fineness Alloys for Obtaining Wire for Jewelry Purpose
Authors: Sidelnikov Sergey Borisovich , Ditkovskaia Yuliia Dmitrievna , Lopatina Ekaterina Sergeevna , Voroshilov Denis Sergeevich , Lebedeva Olga Sergeevna , Konstantinov Igor Lazarevich , Galiev Roman Ilsurovich , Mansurov Yulbarskhon Nabievich , Ber Vladimir Ivanovich , Rudnitskiy Edvard Anatolyevich , Lopatin Vladimir Aleksandrovich 
Published: August 2021

Abstract
The results of studies of the process of obtaining wire for the manufacture of jewelry chains from new nickel-free 585 gold fineness alloys are presented.New 585 gold fineness alloys, alloyed with palladium, silver and other elements, and as modifiers - with rhodium and ruthenium in the stated quantities have been proposed.By modeling the process of section rolling of rods in octagonal calibers using the variation method of minimum total power, the broadening of the metal and the energy-power parameters of rolling rods from the investigated alloys have been determined. The regularities of their change have been found. Software has been developed for designing processes for the production of longish deformed semi-finished products and technological modes of rolling and drawing of new gold alloys.With the help of experimental studies, the adequacy of the results of calculations and modeling was checked and new data were obtained on the mechanical properties of the metal and its structure.It has been found that the proposed alloys and the modes of their processing using the processes of section rolling and drawing make it possible in industrial conditions to obtain jewelry wire with a diameter of up to 0.25 mm with the level of mechanical and operational properties required for chain tying.
Validation of a Back Pain Severity Prediction Algorithm: A Cross-Sectional Study with Updated Healthcare Costs for Back Pain Patients Based on the Graded Chronic Pain Scale
Authors: Hochheim Martin , Ramm Philipp , Wunderlich Max , Amelung Volker 
Published: August 2021

Abstract
Background: Treatment of chronic lower back pain (CLBP) should be stratified for best medical and economic outcome. To improve targeting of potential participants for exclusive therapy offers by payers, Freytag et al. developed an algorithm to identify back pain chronicity classes (CC) based on claims data. The aim of this study was the external validation of the algorithm, as this was previously lacking.Methods: Administrative claims data and self-reported patient information of 3,506 participants of a health management programme of a private health insurance in Germany were used to validate the algorithm. Sensitivity, specificity and Matthews correlation coefficient (MCC) were computed comparing the prediction with actual grades based on von Korff’s Graded Chronic Pain Scale (GCPS). Secondary outcome was an updated view on direct health care costs (€) of back pain (BP) patients grouped by GCPS.Results: Results showed a fair correlation between predicted CC and actual GCPS grades. A total of 69.7 % of all cases were classified correctly. Sensitivity and specificity rates of 54.6 % and 76.4 % underlined the accuracy. Correlation between CC and GCPS with an MCC of 0.304 also indicated a fair relationship between prediction and observation. Cost data could be clearly grouped by GCPS: the higher the grade, the higher the costs and health care usage.Conclusions: This was the first study to compare the predicted BP severity using claims data with actual BP severity by GCPS. Based on the results, the usage of the CC as a single tool to determine who receives treatment of CLBP cannot be recommended. The CC is a good tool to segment candidates for BP specific types of intervention. However, it cannot replace a medical screening at the beginning of an intervention as the rate of false negatives is too high. Trial registration: The study was conducted using routinely collected data from an intervention, which was evaluated and registered previously at the German Clinical Trials Register under DRKS00015463 retrospectively (4 Sept 2018). The informed consent and the self-reported questionnaire have remained unchanged since the study and are therefore still valid in accordance with the ethics proposal.
The Application of Hydrogel in Agriculture for Reducing High Pumping of Irrigation Water in Algeria
Authors: Boutalbi Abdelhakim , NILI Mohammed seghir 
Published: August 2021

Abstract
The application of hydrogel in agriculture has gained a wide interest in the last decades due to the great benefits that it has provided to this sector. In Algeria, agriculture suffers from two main issues: water shortage and climate change, especially in the south of the country (Sahara), which is classified within the arid and semi-arid regions, where irrigation is based exclusively on groundwater. This paper presents an experiment of hydrogel application in agricultural soil for reducing overexploitation of groundwater used for irrigation. Hydrogels are super absorbent polymers. They are biodegradable and have the ability to absorb and retain a large amount of water. The aim of this work is to evaluate the effect of hydrogel on the efficiency of soil moisture retention through treating sandy soil with different doses of hydrogel. The results indicate that the application of hydrogel can increase the water retaining capacity of sandy soil up to 40%.
Effect of Fecal Microbiota Transplantation on Primary Hypertension and the Underlying Mechanism of Gut Microbiome Restoration: Protocol of a Randomized, Double-Blinded, Placebo-Controlled Study
Authors: Fan Luyun , Ren Jie , Chen Youren , Wang Yang , Guo Zihong , Bu Peili , Yang Jinfeng , Ma Wenjun , Zhu Bingpo , Zhao Yanyan , Cai Jun 
Published: August 2021

Abstract
BackgroundHypertension is in current the leading modifiable cause of global morbidity and mortality, contributing to substantial health and financial burdens. Although multiple explorations on management models and innovative therapeutic strategies of hypertension, vacancy still occur in the field with poor control rate reflected and lacking of novel, effectively clinical-translated medication or intervention options. Recent animal and human studies repeatedly confirmed a link between microbiota and hypertension. Of note is our previous study establishing a cause-and-effect relationship between gut microbiota and blood pressure elevation. A hypothesis of gut microbiota intervention on treating hypertension is thus postulated with fecal microbiota transplantation(FMT) from healthy donors performed. MethodsA multi-center, central randomized, placebo-controlled, double-blinded clinical trial is performed in 120 grade 1 hypertensive patients for overall three months. All recruited patients will be randomly assigned in a 1:1 ratio into orally-taken FMT capsules or placebo capsules with three interventions on day 1, day 7 and day 14 in separate, and followed up on day 30, day 60 and day 90. The primary outcome is the change for office systolic blood pressure from baseline to day 30 follow-up. Main secondary outcomes are BP indicators including changes in systolic and diastolic blood pressure from office, home, and 24-hour ambulatory blood pressure monitoring, assessments of ankle-branchial index and pulse wave velocity, profiling of fecal microbial composition and function, profiling of fecal and serum metabolome, changes in levels of blood glucose, blood lipids and body mass index, assessment of adverse events as a measure of safety. DiscussionStretching from our previous research on the role of gut microbiota in the pathogenesis of hypertension, this study serves as a clinical translation advancement and firstly explores the potential of fecal microbiota transplantation on treating hypertension. Underlying mechanisms particularly on anchoring specific microorganisms or their postbiotics contributing to blood pressure amelioration will also be investigated via multiple approaches such as metagenomic sequencing and metabolomic profiling.Trial registrationClinicalTrials.gov Identifier: NCT04406129, registried on May 28th, 2020, https://clinicaltrials.gov/ct2/show/NCT04406129
New Aspects of Radiotherapy in Rheumatoid Arthritis Biomarker: Radio Sensitivity Response to Acute Ionizing Radiation Induces Cell Characteristic Reprogramming and Enhanced Cytokine Release of In Vitro Activated Macrophage Cell Line (RAW 264.7)
Authors: Bagheri-Hosseinabadi Zahra , Zafari Jaber , Jouni Fatemeh Javani , Abbasinia Hossein , Abbasifard Mitra 
Published: August 2021

Abstract
The response of biological systems to various types of radiations have many ambiguous dimensions. Among ionizing radiations, in vitro external gamma radiation therapy has mostly studied as model to declare the biological system challenges with radiation effects. Cell/organism exposure to gamma radiation, caused cascade of ionization events such as severe irreversible biological damages. However, the biological responses and oxidative stress related mechanisms under acute radiation conditions poorly understood in inflammatory systems. Following study tried to give a model about ionizing radiation effect on the macrophage that had a key role in inflammation mechanisms; to evaluate the impact of radiotherapy approach for inflammatory disease as rheumatoid arthritis. To this aim, Macrophage cell line (RAW 264.7) culture, exposed to different doses of gamma radiation (0,4, 6, 8, 10 Gy). Cell viability, apoptosis, cell cycle, migration; NO and PGE2 production; expression of pro-inflammatory and apoptotic genes and cytokine secretion of macrophages was also evaluated.The results showed that gamma treatment, at 4 Gy radiation, have slight effect on macrophage characteristics and cytokine secretion pattern. Versus, higher doses (8 and 10 Gy) increased DNA damage, expression of apoptotic genes and secretion of NO and PGE2 cytokines. 6 Gy radiation, the maximum radiation dose, show moderate nondestructive effects and inflammation process modulation. In this study, doses higher than 6 Gy of Gamma radiation caused cell mortality. It seems that 6 Gy Gamma radiation modulate the inflammatory cascade caused by macrophage cell, as a central core of autoimmune inflammatory disease in acute dose radiation therapy.
Diagnostic Value of Nanopia® KL-6 in Chinese Patients with Interstitial Lung Disease: A Prospective Multicenter Observational Study
Authors: Guo Bingpeng , Han Qian , Wang Wenjie , Zhang Ziyi , Sun Baoqing , Kang Jian , Zhao Yabin , Xu Zuojun , Huang Hui , Zhong Nanshan , Luo Qun 
Published: August 2021

Abstract
Background: Krebs von den Lungen-6 (KL-6) is considered a sensitive biomarker for diagnosis of interstitial lung disease (ILD). We aimed to evaluate the diagnosis value of Nanopia® KL-6 (SEKISUI MEDICAL CO., LTD., Tokyo, Japan) in a Chinese cohort of patients with ILD.Methods: Totally 451 patients were enrolled in our multicenter study, including 166 (36.8%) ILD patients, 210 (46.6%) non-ILD patients and 75 (16.6%) health controls. All ILD patients underwent high-resolution computed tomography (HRCT) followed by pulmonary function test (PFT). Serum KL-6 concentrations were measured by latex particle enhanced turbidimetric immunoassay (LTIA).Results: KL-6 serum concentrations were significantly higher in ILD patients (911 U/ml, IQR 477-1790) than in non-ILD patients (225 U/ml, IQR 166-323) and health controls (196 U/ml, IQR 153-230, p<0.0001). Serum KL-6 higher than 435.5 U/ml appeared as the optimal cut-off value associated with ILD. KL-6 concentrations were inversely correlated with forced vital capacity (FVC) (rho=-0.515, p<0.001), total lung capacity (TLC) (rho=-0.563, p<0.001) and diffuse lung capacity of carbon monoxide (DLco) (rho=-0.544, p<0.001). ILD patients with more severe characteristics of HRCT including ground glass opacity, reticular pattern or honeycombing had significantly higher serum KL-6 levels. In the subgroup of ILD patients, serum KL-6 concentrations were higher in idiopathic interstitial pneumonia (IIP) patients (1024U/ml, IQR 697-2112.25) than in other ILD patients (743U/ml, IQR 702.75-2058.25, p<10-4). ILD and retained smoking were independent factors associated with higher KL-6 levels in multivariate analysis. Conclusions: Our study confirms that KL-6 is a credible biomarker for the diagnosis of ILD in a Chinese cohort of patients. High serum KL-6 concentration should call attention to physicians to assess ILD with HRCT and PFT.
The Clinical and Pathological Characteristics of Mammary Neoplasms with Malignant Mesenchymal Components in Female Dogs
Authors: Prates Klaus Scherer , Oliveira Priscilla Lucas , Bueno Thaís Silveira , Damasceno Karine Araújo , Driemeier David , Sonne Luciana , Pavarini Saulo Petinatti , Rodrigues Angélica Cavalheiro Bertagnolli 
Published: August 2021

Abstract
Mammary neoplasms with malignant mesenchymal components are not common in female dogs, and they are poorly understood. As such, this study aimed to describe the clinical presentation, histological findings, and the COX-2 immunohistochemical expression of mammary neoplasms in female dogs with malignant mesenchymal components, as well as verify the relationships between the different neoplasm types and these aspects. We selected 41 female mammary neoplasms (23 carcinosarcomas, 16 sarcomas, and 2 sarcomas in mixed tumors). Medical records were reviewed to obtain clinical data. Subsequently, histological slides were analysed to establish histological parameters, and immunohistochemistry was used to assess the expression of COX-2 receptors. Carcinosarcomas and sarcomas developed as large tumours, mainly in the abdominal and inguinal mammary glands, with frequent intratumoral necrosis and a low frequency of nodal metastasis. Fifty-eight percent of the cases of malignant mesenchymal proliferation were identified as osteosarcomatous, and 24.5% chondrosarcomatous and fibrosarcomastous each. The osteosarcomatous pattern was the most predominant type in sarcomas and carcinosarcomas, and was the only one that resulted in vascular invasion, regional lymph node metastases, and higher histologic grades. High COX-2 expression was detected in 10% of the carcinosarcomas and 25% of the sarcomas. In conclusion, sarcomas and carcinosarcomas showed similar results regarding the clinical and pathological aspects. Discovering carcinosarcomas and sarcomas with high COX-2 expression suggests that, in some cases, these neoplasms may respond to therapy with COX-2 inhibitors.
Strain and Electric Field Modulated Indirect to Direct Band Transition of Monolayer GaInS2
Authors: Betal Atanu , Bera Jayanta , Sahu Satyajit 
Published: August 2021

Abstract
Strain and electric field dependent electronic and optical properties have been calculated using density functional theory (DFT) and time-dependent DFT (TD-DFT) for GaInS2 monolayer. GaInS2 monolayer shows an indirect band gap of 1.79 eV where valance band maxima (VBM) and conduction band maxima (CBM) rest between K and Γ point and at Γ point, respectively. Under a particular tensile strain (8%), a phase change from semiconductor to semimetal has been noticed. While at 4% compressive strain, the material changes from indirect to direct band gap of 2.22 eV having VBM and CBM at Γ point. With further increase in compressive strain, CBM shifted from Γ to M point, which leads to an indirect band gap again. The electric field also affects the band structure of monolayer GaInS2 and shows the transition between indirect to direct band gap at positive electric field of 4 V/nm, which acts normal to the surface. The strain-dependent optical properties are also calculated, which suggests that the absorption coefficient increases with compressive strain.
The Effects of Socioeconomic Status, Parental Education Level, Oral and Dental Health Practices, Dietary Habits and Anthropometric Measurements on Dental Health in 12-Year-Old School Children
Authors: CEYLAN Jiyan ASLAN , ASLAN YUSUF , OZCELİK AYSE OZFER 
Published: August 2021

Abstract
Background

Dental caries is the most common progressive chronic disease in school-age children with an increasing prevalence as children grow up. This study aims to examine the effects of socioeconomic status, parental education level, oral and dental health practices, dietary habits and anthropometric measurements on dental health in 12-year-old schoolchildren.
Methods

The sample of the study consisted of 254 children (44.1% boys and 55.9% girls) in three schools, which were identified as low, moderate and high socioeconomic status.
Results

It was found that 70.9% of the children have dental caries on their permanent teeth. The frequency of seeing a dentist, the status of receiving oral and dental health education and the frequency of changing toothbrush vary according to the socioeconomic status. Oral and dental health indicators were determined to be affected by the frequency and duration of tooth brushing. It was found that dmft values of the children consuming molasses and table sugar are higher. There is a negative correlation between oral and dental health indicators and anthropometric measurements and parental education level.
Conclusions

Dietary habits, anthropometric measurements, oral and dental health practices, gender, and parental socioeconomic status and education level were shown to be effective on caries risk.