bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of neoadjuvant nimotuzumab for gastric cancer
Authors: Cao Bin , Wang Qian , Fu Xiao-li , Wei Guo-dong , Zhao Long , Zhang Pei-jun , Li Dairong , Zhang Hui-qing , Zhang Qi 
Published: December 2021

Abstract

Introduction:
The efficacy of neoadjuvant nimotuzumab for gastric cancer remained controversial. We conducted a systematic review and meta-analysis to explore the efficacy of neoadjuvant nimotuzumab plus chemotherapy vs chemotherapy for gastric cancer.

Methods:
We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2019, and included randomized controlled trials assessing the efficacy of neoadjuvant nimotuzumab plus chemotherapy vs chemotherapy for gastric cancer. This meta-analysis was performed using the random-effect model.

Results:
Four randomized controlled trials were included in the meta-analysis. There were 128 patients included in intervention group and 131 patients included in control group. Overall, compared with chemotherapy for gastric cancer, neoadjuvant nimotuzumab plus chemotherapy showed no substantial influence on response rate (risk ratio [RR] = 1.22; 95% CI = 0.78–1.89; P = .38), disease control rate (RR = 2.22; 95% confidence interval [CI] = 0.32–15.40; P = .42), rash (RR = 1.26; 95% CI = 0.96–1.66; P = .10), neutropenia (RR = 1.26; 95% CI = 0.96–1.66; P = .10), anemia (RR = 1.08; 95% CI = 0.62–1.89; P = .78), or nausea (RR = 1.19; 95% CI = 0.96–1.48; P = .12), but might improve the incidence of vomiting (RR = 1.60; 95% CI = 1.03–2.50; P = .04).

Conclusions:
Neoadjuvant nimotuzumab might provide no additional benefits to the treatment of gastric cancer.
Comparison of administration of single- and triple-course steroid pulse therapy combined with tonsillectomy for immunoglobulin A nephropathy
Authors: Watanabe-Kusunoki Kanako , Nakazawa Daigo , Yamamoto Junya , Matsuoka Naoko , Kaneshima Nobuharu , Nakagaki Tasuku , Yamamoto Rie , Maoka Tomochika , Iwasaki Sari , Tsuji Takahiro , Fukasawa Yuichiro , Nishimoto Naoki , Nishio Saori , Atsumi Tatsuya 
Published: December 2021

Abstract
Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis that can cause end-stage renal disease. Recently, tonsillectomy combined with corticosteroid pulse (TSP) has been shown to be effective for achieving clinical remission and favorable renal outcome in patients with IgAN. However, the standard regimen of corticosteroid use in TSP has not been established. Herein, we compared the effect of single- or triple-course steroid pulse therapy combined with tonsillectomy in patients with IgAN.
This retrospective, observational cohort study included 122 patients with IgAN enrolled from January 2004 to December 2018 at 2 independent institutions. We divided the patients into 2 groups; single-course (TSP1: n = 70) and triple-course (TSP3: n = 52) of corticosteroid pulse therapy (1 course comprised 3 consecutive days’ infusion of 0.5 g methylprednisolone) combined with tonsillectomy. The primary outcome for renal survival was defined as the first occurrence of ≧30% decrease in estimated glomerular filtration rate from baseline. Secondary outcomes included the incidence of clinical remission and recurrence of the disease.
Regarding clinical parameters and findings at baseline, there were no significant differences between the 2 groups. The 8-years renal survival in the 2 groups was not significantly different according to Kaplan–Meier curves (TSP1; 82.5% vs TSP3; 69.2%, log-rank test P = .39). The cumulative incidence rates of remission of hematuria (94.4% vs 85.4%, P = .56) and clinical remission (85.0% vs 64.8%, P = .07) were comparable in both groups, while those of proteinuria showed higher rates in TSP1 than TSP3 (88.4% vs 65.4%, P = .02). The cumulative incidence of relapse of hematuria (5.6% vs 2.3%, P = .42) and proteinuria (7.1% vs 3.3%, P = .41) showed no significant differences in the 2 groups. Cox regression analyses showed that the number of courses of corticosteroid pulse therapy was not significantly associated with renal outcome (TSP1 vs TSP3; Hazard ratios 0.69, 95% confidence intervals 0.29-1.64, P = .39).
The effect of single-course corticosteroid pulse therapy is not statistically, significantly different from triple-course in TSP protocol for improving renal outcome and preventing relapse in patients with IgAN. Single-course corticosteroid pulse therapy may become a treatment option for patients with IgAN.
Current status of laparoscopic hepatectomy for the treatment of hepatocellular carcinoma
Authors: Hendi Maher , Lv Jiemin , Cai Xiu-Jun 
Published: December 2021

Abstract

Background:
Laparoscopic hepatectomy (LH) was first introduced in the 1990s and has now become widely accepted for the treatment of hepatocellular carcinoma (HCC). Laparoscopic liver resection (LLR) is considered a safe and effective approach for liver disease. However, the role of laparoscopic hepatectomy in HCC with cirrhosis remains controversial and needs to be further assessed, and the present literature review aimed to review the surgical and oncological outcomes of Laparoscopic hepatectomy (LH). According to Hong and colleagues laparoscopic resection for liver cirrhosis is a very safe and feasible procedure for both ideal cases and select patients with high risk factors [29]. The presence of only 1 of these factors does not represent an absolute contraindication for LH.

Methods and results:
We selected 23 studies involving about 1363 HCC patients treated with LH. 364 (27%) patients experienced major resections. The mean operative time was 244.9 minutes, the mean blood loss was 308.1 mL and blood transfusions were required in only 4.9% of patients. There were only 2 (0.21%) postoperative deaths and overall morbidity was 9.9%. Tumor recurrence ranged from 6 to 25 months. The 1-year, 3-year, and 5-year disease free Survival (DFS) rates ranged from 71.9% to 99%, 50.3% to 91.2%, and 19% to 82% respectively. Overall survival rates ranged from 88% to 100%, 73.4% to 94.5%, and 52.6% to 94.5% respectively.

Conclusions:
In our summery LH is lower risk and safer than conventional open liver surgery and is just as efficacious. Also, the LH approach decreased blood-loss, operation time, postoperative morbidity and had a lower conversion rate compared to other procedures whether open or robotic. Finally, LH may serve as a promising alternative to open procedures.
Efficacy and safety evaluation of bright light therapy in patients with post-stroke insomnia
Authors: Lei Huabin , Wang Wei , Cao Yinan , Ma Yaru , Xue Xusheng 
Published: December 2021

Abstract

Background:
Post-stroke insomnia (PSI) is a common and severe illness among the complications of stroke. Although there are plenty of drugs currently used for PSI treatment, they generate several side effects and other problems. Bright light therapy (BLT) is thought to be relatively safe and effective in treating PSI patients. Despite this, there is still a lack of systematic review on BLT in the treatment of PSI. Allowing for this, the aim of this study is to assess the efficacy and safety of BLT for PSI.

Methods:
The meta-analysis and systematic review will perform a comprehensive electronic search for items fulfilling the required criteria in Web of Science, Google Scholar, Wan Fang database, MEDLINE, Baidu Scholar, PubMed, SinoMed, Embase, Chinese Biomedical Literature Database (CBM), China national knowledge infrastructure database (CNKI), Cochrane Library Central Register of Controlled Trials (CENTRAL), and Wei Pu database from establishment to January 1, 2022. We will select articles, collect data, and assess the methodology quality. And we will set the primary outcome and secondary outcomes in this research. RevMan 5.3 software will be used to analyze the data for this investigation.

Results:
The work of this research will be published in peer-reviewed scientific journals.

Conclusion:
The aim of this study is to assess the efficacy and safety of BLT for PSI and present robust scientific evidence concerning BLT for PSI.

Registration:
INPLASY2021100065.
Efficacy and safety of unilateral biportal endoscopy compared with microscopic decompression in the treatment of lumbar spinal stenosis
Authors: Li Chuntao , Ju Fei , Li Wenyi , Gao Shangju , Cao Can , Li Changren , He Liang , Ma Xu , Li Meng 
Published: December 2021

Abstract

Objective:
Systematic evaluation of the efficacy and safety of unilateral biportal endoscopic decompression in the treatment of lumbar spinal stenosis.

Methods:
We conducted a systematic literature search and compared the randomized controlled trials (RCTs) and retrospective studies of unilateral biportal endoscopy (UBE) and microscopic decompression (MD) in the treatment of lumbar spinal stenosis from several databases.

Results:
Seven studies were included. The results of meta-analysis showed that the operation time of UBE was shorter than that of MD. [SMD = −0.443, 95% CI (−0.717, −0.169), P
= .002]. Compared with MD, the patients’ back pain was slighter on the 1st day, 1–2 months and 6 months after UBE. During the long-term follow-up, there was no significant difference in back pain between MD and UBE [SMD = −0.519, 95% CI (−0.934, −0.104), P
= .014]. There was no significant difference in lower limb visual analogue score (VAS) score between UBE decompression and MD [SMD = −0.105, 95% CI (−0.356, 0.146), P
= .412]. The results of meta-analysis showed that the C-reactive protein (CRP) level of UBE was lower than that of MD [weighted mean difference = −1.437, 95% CI (−2.347, −0.527), P
= .002]. There was no significant difference in other clinical effects between the 2 groups.

Conclusion:
The operation time of UBE was shorter than that of MD, and it was superior to micro decompression in early back VAS score, lower limb VAS score and early postoperative CRP level. There was no statistical difference between UBE and MD in other outcomes.
Clinical use of platelet-rich fibrin in the repair of non-healing incision wounds after fibular fracture surgery
Authors: Lin Xingzhen , Zhu Manhua , Yuan Juan , Zhi Fang , Hou XinJu 
Published: December 2021

Abstract

Rationale:
This report describes rehabilitation for a 53-year-old female recovering from non-healing skin and soft tissue defect after distal tibial open fracture by using platelet-rich fibrin topical repair following an automobile accident.

Patient concerns:
The patient was admitted to a rehabilitation specialty hospital approximately 1 year post a fracture of the distal left tibiofibula and separate surgical tibiofibular fracture incision and internal fixation + bone grafting.

Diagnoses:
Clinical presentation included the left ankle incision was interrupted for about 3 cm with poor healing, a small amount of muscle necrosis, fat liquefaction, a large amount of yellow purulent secretion overflow and necrotic material was seen in the local wound.

Interventions:
Platelet rich fibrin (PRF) gel was injected into the wounds and submerged sites to make full contact with the wounds and close the wounds with the autologous platelet-rich fibrin prepared by mixing, and then covered with oil gauze to keep the wounds moist and promote granulation growth. The outermost layer was covered with cotton pads.

Outcomes:
After 30 days of 2 PRF treatments, the skin defect was healed and no significant abnormality was observed at 6 months follow-up.

Lessons:
Treatment with topical autologous platelet-rich plasma gel Significantly accelerates the healing of wounds, shortens healing time, improves healing quality and reduces scar formation without significant adverse effects.
Melanotic neuroectodermal tumor of infancy in the mandible
Authors: Takeuchi Ryoko , Funayama Akinori , Oda Yohei , Abé Tatsuya , Yamazaki Manabu , Maruyama Satoshi , Hayashi Takafumi , Tanuma Jun-ichi , Kobayashi Tadaharu 
Published: December 2021

Abstract

Rationale:
Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted treatment is removal by surgical resection. Herein, we report a case of MNTI that involved the anterior alveolar ridge of the mandible in a 6-month-old infant.

Patient concerns:
A case of a 6-month-old male child with a huge mass in the anterior alveolar ridge of the mandible.

Diagnosis:
The tumor was diagnosed using histopathological and immunohistochemical techniques on the biopsy specimen obtained following incisional biopsy. Based on the findings, a final diagnosis of MNTI was established.

Interventions:
Radical resection of the tumor was performed, after determining the extent of resection by referring to the mandibular 3D model created using the pre-operative CT data.

Outcomes:
The postoperative course was uneventful, and no recurrence has been observed to date for more than 4 years after surgery.

Lessons:
This case emphasizes that early diagnosis and radical surgery are critical to the effective treatment, as MNTI exhibits rapid and destructive growth. It also requires careful and close follow-up because of high recurrence rates.
Synchronous occurrence of HPV-associated cervical squamous cell carcinoma (FIGO IIA) in prolapsed uterus and adenocarcinoma of the anal canal cT1N0M0
Authors: Skręt Andrzej , Trawińska Joanna , Bielatowicz Joanna , Książek Mariusz , Niewęgłowska-Guzik Beata , Radkowski Andrzej , Kargol Jaromir , Magierło Joanna Skręt- , Barnaś Edyta , Gawlik Bogusław 
Published: December 2021

Abstract

Rationale:
Guidelines of rare synchronous tumours treatment are often unavailable due to lack of wide prospective studies. Additionally, their management is not just a simple sum of coexisting tumours management and has to regard many circumstances like symptoms, age, comorbidities, advancement.

Patient concerns:
Herein, we report a case of an 81-year-old woman who presented with bleeding from the prolapsed uterus.

Diagnoses:
Based on physical examination, that is, speculum examination, bimanual, and per rectum, followed by rectoscopy and histopathology, the diagnosis of cervical squamous cell carcinoma FIGO IIA2 in prolapsed uterus with anal canal adenocarcinoma cT1N0M0 was made.

Interventions:
Dominating complaint of bleeding from prolapsed cervix was managed with radical vaginal hysterectomy in conjunction with wide colpectomy preceded by laparoscopic pelvic and paraaortic lymphadenectomy. Due to the lack of consent for removal of the anus, only radiotherapy was applied instead.

Outcomes:
The patient underwent magnetic resonance image follow-up. No recurrence was found at 18 months.

Lessons:
Imaging is useful method of synchronous cancers diagnostics. These cancers may vary in aetiology and stage. Cervical cancer may be co-existing with another anogenital cancer. Therapy of synchronous cancers should be individualized taking into account patient's consent, age, physical condition, and comorbidities.
Lymphocyte-activating gene-3 expression is associated with tumor-infiltrating lymphocyte levels in HER2-positive breast cancers
Authors: Lee Seokwon , Kim Jee Yeon , Lee So Jeong , Kwon Soon Wook , Jung Ho Jin , Jung Se Jin , Kim Kyung Bin , Choi Kyung Un , Lee Chang Hun , Huh Gi Yeong , Kim Ahrong 
Published: December 2021

Abstract
Lymphocyte-activating gene-3 (LAG-3, CD223) is the third inhibitory receptor targeted for immunotherapy. Several clinical trials investigating the use of interventions targeting LAG-3 are underway. The exact signaling mechanism downstream of LAG-3 is largely unknown, especially in breast cancer. The prognostic significance of tumor-infiltrating lymphocytes (TILs) in breast cancer has been previously determined.
Among 167 human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, 90 and 78 patients were positive and negative for the hormone receptor, respectively. LAG-3 mRNA and protein expression levels in TILs were evaluated by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively, among 12 and 167 HER2-positive breast cancer samples, respectively.
High expression of LAG-3 in TILs was significantly correlated with high levels of TILs (P = .003) and an abundance of tertiary lymphoid structures around invasive components (P = .014). In addition, high expression of LAG3 was significantly associated with positivity for programmed death-ligand 1 (PD-L1) in tumor cells, a high immunostaining score of PD-L1 in TILs, and a high total immunostaining score for PD-L1 in tumor cells and TILs (all, P < .001). High expression levels of LAG-3 mRNA were associated with high levels of TILs (P = .091).
LAG-3 protein expression was not a prognostic factor in HER2-positive breast cancers, and LAG-3 expression in TILs was significantly associated with the levels of TILs in HER2-positive breast cancer, although it was not a prognostic factor.
Improving knowledge and perception of HIV/AIDS among English language speaking children in rural areas through educational digital storytelling
Authors: Dike Ibiwari Caroline , Ebizie Elizabeth N. , Njoku Obiageli C. , Oraelosi Charles A. , Egbe Cajetan Ikechukwu , Nnamani Amuche Patricia , Ezeaku Margret N. , Ihuoma Ekomaru Chinyere , Otu Mkpoikanke Sunday , Okechukwu Franca Obiageli , Anowai Chinwe Christiana , Nnodim Ezine Judith , Ukwuezeh Chika Priscillia , Onuorah Adaorah R. , Onwuegbuchulam Adaobi Chinenyenwa 
Published: December 2021

Abstract

Background/Objective:
Previous research efforts have shown the need for improvement of knowledge and perception of HIV/AIDS among English Language speaking children in rural areas. Hence, the study at hand was designed to investigate the effect of using educational digital storytelling intervention to satisfy this need of English Language children in rural areas in Nigeria.

Method:
The study adopted a randomized control design involving a pretest, post-test, and follow-up measures. Eight-four children (n = 84) took part in the study. The HIV Knowledge Questionnaire (HIV-KQ-18) and the Perceived Risk of HIV Scale (PRHS) were used for data collection. Data were analyzed using t test statistics.

Result:
The educational digital storytelling intervention in appreciably improved knowledge and perception of English language children in rural areas who participated in the intervention concerning HIV/AIDS compared with their peers in the no-intervention control group. The improvement in knowledge and perception gained was also maintained throughout the follow-up evaluation period.

Conclusion:
The present study showed that the use of educational digital storytelling could improve knowledge and perception of HIV/AIDS among English Language speaking children in rural areas. Educational digital storytelling intervention effectively improved knowledge and perception of HIV/AIDS among children in rural areas. In return, we recommend that rural sociologists, counselors, language and communication experts, child educators, and other professionals involved in public health especially, as it concerns children be skilled in the use and application of educational digital storytelling intervention procedures to facilitate the move towards adopting the method in their professional practices.
Tracheal rupture after vocal cord polyp resection
Authors: Hu Xinqi , Chen Xiaofeng , Cui Xidong , Cao Yitan , Sun Guangbin 
Published: December 2021

Abstract

Introduction:
Transoral laser microsurgery (TLM) is one of the most common operations performed for glottic lesions. Several protection measures are taken to prevent tracheal damage. However, some protection measures and common postoperative complications may still cause delayed tracheal rupture in certain situations. Cases of tracheal rupture after surgery are extremely rare, and there are no previous reports of TLM of the glottis causing tracheal rupture.

Patient concerns:
A middle-aged woman who underwent TLM for bilateral vocal cord polyps developed sudden neck pain, followed by cough and subcutaneous emphysema.

Diagnosis:
She underwent head, neck, and chest computed tomography (CT), which revealed a 4-cm membranous tracheal tear located 4.5 cm distal to the glottis, pneumomediastinum, and subcutaneous emphysema extending from the base of skull to the chest.

Interventions:
The patient underwent an emergency surgical surgical chest exploration and tracheal repair.

Outcomes:
One month after the surgery, the patient fully recovered with no tracheal stenosis or respiratory dysfunction.

Conclusions:
Conventional protective measures and common postoperative complications of TLM may also cause tracheal rupture.
Sports injuries and risk factors for table tennis among nonprofessional collegiate athletes
Authors: Teo Moeka Mong Jia , Chang Feng-Hang , Lin Yen-Nung 
Published: December 2021

Abstract
Despite the increasing popularity of table tennis worldwide, few studies have focused on table tennis injuries.
This study aimed to investigate the injury profiles, including the injury rate, types, locations, and risk factors, among nonprofessional collegiate table tennis athletes in Taiwan.
We performed an online investigation among collegiate table tennis athletes of the nonprofessional category in the 2019 National Intercollegiate Athletic Games in Taiwan. Participants provided general information, and data on the characteristics of their play style, training, and injuries were collected. We then categorized these participants into injured and noninjured groups. Injuries were classified as mild, moderate, and severe, based on the time loss in playing table tennis. The risk factors for table tennis-related sports injuries were then identified through between-group comparisons.
In total, 150 participants responded to the questionnaire. The average participant age was 21.3 years. Gender differences existed in age categories, forehand rubber, backhand style of play, and average days of training per week. Over the 6 months before the study, 76 of 150 participants experienced at least one injury. The handedness for play was associated with the occurrence of injury. Factors associated with injury severity included using rubber other than inverted rubber for the forehand and not qualifying for the national round of the team category of the National Intercollegiate Athletic Games.
With a considerably high injury rate among nonprofessional collegiate athletes, further studies are required on table tennis-related injuries. Playing styles such as handedness and type of rubber used might be associated with the injury. The lower limb was the most common site of injury. These results may provide insights into trainers and coaches for further measures on injury prevention.