bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effects of Sesamin on Cytoxan-Induced Spermatogenesis Dysfunction by Regulating RNF8-ubH2A/ubH2B Pathways in Male Mice
Authors: Hai Dong-Mei , Ren Jia-Wei , Chi Yan-Nan , Ye Rui-Juan , Liu Ning , Ma Lin , Lan Xiao-Bing , Wu Jing , Yu Jian-Qiang , Yang Jia-Mei 
Published: September 2021

Most of the clinically infertile patients show spermatogenesis dysfunction. Cyclophosphamide, as an anticancer drug, can induce spermatogenesis dysfunction. Sesamin is the main bioactive component of natural lignans in sesame. It is abundant in sesame oil and has strong biological activities such as antioxidant, antibacterial, and hypoglycemic properties. By establishing the model of spermatogenic dysfunction induced by cyclophosphamide in male mice and then feeding sesamin (50, 100, and 200 mg/kg) for 2 weeks, we proved that sesamin can improve the reproductive organ damage induced by cyclophosphamide and increase the number and activity of sperms. Sesamin can resist cyclophosphamide-induced sperm nuclear maturity and DNA damage by increasing the expression levels of histones H2A and H2B in the testis. In addition, sesamin can improve the ubiquitination of histones regulated by RNF8 to protect the testis. In conclusion, these results suggest that sesamin can improve spermatogenic dysfunction induced by cyclophosphamide, which may be mediated by ubiquitination of histones.
Strong Early Phase Parasympathetic Inhibition Followed by Sympathetic Withdrawal During Propofol Induction: Temporal Response Assessed by Wavelet-Based Spectral Analysis and Photoplethysmography
Authors: Wang Hsin-Yi , Lo Men-Tzung , Chen Kun-Hui , Mandell Susan , Chang Wen-Kuei , Lin Chen , Ting Chien-Kun 
Published: September 2021

Background: Induction of anesthesia with propofol is associated with a disturbance in hemodynamics, in part due to its effects on parasympathetic and sympathetic tone. The impact of propofol on autonomic function is unclear. In this study, we investigated in detail the changes in the cardiac autonomic nervous system (ANS) and peripheral sympathetic outflow that occur during the induction of anesthesia.Methods: Electrocardiography and pulse photoplethysmography (PPG) signals were recorded and analyzed from 30 s before to 120 s after propofol induction. The spectrogram was derived by continuous wavelet transform with the power of instantaneous high-frequency (HFi) and low-frequency (LFi) bands extracted at 1-s intervals. The wavelet-based parameters were then divided into the following segments: (1) baseline (30 s before administration of propofol), (2) early phase (first minute after administration of propofol), and (3) late phase (second minute after administration of propofol) and compared with the same time intervals of the Fourier-based spectrum [high-frequency (HF) and low-frequency (LF) bands]. Time-dependent effects were explored using fractional polynomials and repeated-measures analysis of variance.Results: Administration of propofol resulted in reductions in HFi and LFi and increases in the LFi/HFi ratio and PPG amplitude, which had a significant non-linear relationship. Significant between-group differences were found in the HFi, LFi, and LFi/HFi ratio and Fourier-based HF and LF after dividing the segments into baseline and early/late phases. On post hoc analysis, changes in HFi, LFi, and the LFi/HFi ratio were significant starting from the early phase. The corresponding effect size (partial eta squared) was &gt; 0.3, achieving power over 90%; however, significant decreases in HF and LF were observed only in the late phase. The PPG amplitude was increased significantly in both the early and late phases.Conclusion: Propofol induction results in significant immediate changes in ANS activity that include temporally relative elevation of cardiac sympathovagal balance and reduced sympathetic activity.Clinical Trial Registration: The study was approved by the Institutional Review Board of Taipei Veterans General Hospital (No. 2017-07-009CC) and is registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT03613961).
Validity and Reliability of Hydraulic-Analogy Bioenergetic Models in Sprint Roller Skiing
Authors: Lidar Julius , Andersson Erik P. , Sundström David 
Published: September 2021

Purpose: To develop a method for individual parameter estimation of four hydraulic-analogy bioenergetic models and to assess the validity and reliability of these models’ prediction of aerobic and anaerobic metabolic utilization during sprint roller-skiing.Methods: Eleven elite cross-country skiers performed two treadmill roller-skiing time trials on a course consisting of three flat sections interspersed by two uphill sections. Aerobic and anaerobic metabolic rate contributions, external power output, and gross efficiency were determined. Two versions each (fixed or free maximal aerobic metabolic rate) of a two-tank hydraulic-analogy bioenergetic model (2TM-fixed and 2TM-free) and a more complex three-tank model (3TM-fixed and 3TM-free) were programmed into MATLAB. The aerobic metabolic rate (MRae) and the accumulated anaerobic energy expenditure (Ean,acc) from the first time trial (STT1) together with a gray-box model in MATLAB, were used to estimate the bioenergetic model parameters. Validity was assessed by simulation of each bioenergetic model using the estimated parameters from STT1 and the total metabolic rate (MRtot) in the second time trial (STT2).Results: The validity and reliability of the parameter estimation method based on STT1 revealed valid and reliable overall results for all the four models vs. measurement data with the 2TM-free model being the most valid. Mean differences in model-vs.-measured MRae ranged between -0.005 and 0.016 kW with typical errors between 0.002 and 0.009 kW. Mean differences in Ean,acc at STT termination ranged between −4.3 and 0.5 kJ and typical errors were between 0.6 and 2.1 kJ. The root mean square error (RMSE) for 2TM-free on the instantaneous STT1 data was 0.05 kW for MRae and 0.61 kJ for Ean,acc, which was lower than the other three models (all P &lt; 0.05). Compared to the results in STT1, the validity and reliability of each individually adapted bioenergetic model was worse during STT2 with models underpredicting MRae and overpredicting Ean,acc vs. measurement data (all P &lt; 0.05). Moreover, the 2TM-free had the lowest RMSEs during STT2.Conclusion: The 2TM-free provided the highest validity and reliability in MRae and Ean,acc for both the parameter estimation in STT1 and the model validity and reliability evaluation in the succeeding STT2.
Urgency in Improving Child Health Care Workers' Awareness and Knowledge of ASD: Findings From a Cross-Sectional Study in Southwest China
Authors: Ma Yu , Zhou Yan , Liu Ye , Ping Yue , Wang Yaozhou , Hu Xiao , Zhang Chenxi , Wang Tianqi , Zhou Hao 
Published: September 2021

Objective: To evaluate the levels of awareness and knowledge of ASD among child health care workers in China, we conducted a cross-sectional, questionnaire-based study to assess the participants' awareness and knowledge of ASD.Methods: A total of 159 child health care workers from Southwest China participated in the survey and filled out the questionnaire.Descriptive analysis was conducted on the five parts of the questionnaire, including general knowledge, symptomology, screening and diagnosis, and intervention and treatment. Univariate analysis was used to assess impacts of the participants' basic demographic characteristics on the questionnaire scores. Multivariate analysis was used to analyze association of the participants' basic demographic characteristics and the questionnaire scores.Results: Less than 15% of the participants knew that ASD is a developmental, congenital and genetic disorder. Few participants knew that the symptoms include language disorder (38.4%) and social dysfunction (29.6%). A minority of the participants knew the diagnostic criteria (22.6%) and the age for early screening (14.5%). A total of 23.9% of the participants agreed that there are no effective drugs to treat ASD, and 6.3% agreed that ASD is incurable. A number of years in practice of ≥10 (OR = 0.3249, 95% CI: 0.1080–0.9189) was the main factor related to a high questionnaire score.Conclusions: Most participants had relatively low levels of awareness and knowledge of ASD, especially in terms of general knowledge as well as knowledge of intervention and treatment. Working for more than 10 years was a significant predictor of higher levels of awareness and knowledge of ASD. ASD-related training and knowledge dissemination are crucial for the early diagnosis and intervention of ASD. Child health care workers' awareness and knowledge of ASD needs to be improved to help build public awareness about ASD.
The Prevalence and Characterization of Fecal Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli Isolated from Pigs on Farms of Different Sizes in Latvia
Authors: Gāliņa Daiga , Balins Andris , Valdovska Anda 
Published: September 2021

The aim of this study was to determine the prevalence of fecal ESBL-producing Escherichia coli (E. coli) in pigs on large and small farms in Latvia, to characterize beta-lactamase genes and establish an antimicrobial resistance profile. Fecal samples (n = 615) were collected from 4-week, 5-week, 6-week, 8-week, 12-week and 20-week-old piglets, pigs and sows on four large farms (L1, L2, L3, L4) and three small farms (S1, S2, S3) in Latvia. ChromArt ESBL agar and combination disc tests were used for the screening and confirmation of ESBL-producing E. coli. The antimicrobial resistance was determined by the disc diffusion method and ESBL genes were determined by polymerase chain reaction (PCR). Subsequently, ESBL-producing E. coli was confirmed on three large farms, L1 (64.3%), L2 (29.9%), L3 (10.7%) and one small farm, S1 (47.5%); n = 144 (23.4%). The prevalence of ESBL-producing E. coli differed considerably between the large and small farm groups (26.9% vs. 12.7%). Of ESBL E. coli isolates, 96% were multidrug-resistant (MDR), demonstrating there were more extensive MDR phenotypes on large farms. The distribution of ESBL genes was blaTEM (94%), blaCTX-M (86%) and blaSHV (48%). On the small farm, blaSHV dominated, thus demonstrating a positive association with resistance to amoxicillin-clavulanic acid, ceftazidime and cefixime, while on the large farms, blaCTX-M with a positive association to cephalexin and several non-beta lactam antibiotics dominated. The results indicated the prevalence of a broad variety of ESBL-producing E. coli among the small and large farms, putting the larger farms at a higher risk. Individual monitoring of ESBL and their antimicrobial resistance could be an important step in revealing hazardous MDR ESBL-producing E. coli strains and reviewing the management of antibiotic use.
HUMANISTIC CONCEPT OF IVAN ZIAZIUN IN CURRENT AND FUTURE PROSPECTS
Authors: Stepanenko Mykola 
Published: September 2021

The article describes the humanistic paradigm of Ivan Ziaziun on the harmonious synthesis of art and pedagogy in teacher training. In particular, the philosophical and pedagogical and organizational and managerial ideas of a scientist- philosopher and teacher, a long-time rector of Poltava V. G. Korolenko State Pedagogical Institute have been discovered. Pedagogy of humanity of Academician I. Ziaziun through the system of professional training in Poltava V. G. Korolenko State Pedagogical Institute – the formation of a person, the formation of a strategy for person’s development and self-development, the basis of which is the value-semantic constituency of a man have been estimated from the diachronic-synchronous positions. A significant feature in the research is given to the ideas of the personal subject-subject and environment approaches to the training of the future teacher, the idea of forming the image of a higher educational institution as a leader of the region, self-management and autonomy of higher education institutions. Moreover, the system of professional training (careful selection and individual work with young people who show a tendency to pedagogical activity) through the establishment (on the initiative and with the direct participation of Ivan Ziaziun) a comprehensive target program «Teacher» (School – teacher – school), and its implementation into schools with the help of introduction of an optional course «Young teacher», with the help of selecting institutions that interviewed university entrants, and recommended those who are capable to study in higher educational institutions. The constituents of Ivan Ziaziun's humanistic conception are presented in the projection on the basis of the continuity of education postulates: formal, nonformal, and informal. In this aspect, the following priorities were determined such as training at Poltava Pedagogical Institute, first of all through the introduction of the special course «Fundamentals of Pedagogical Teaching Excellence», the opening of blended majors, additional qualifications at the Faculty of Public Professions, through the development of informal artistic and educational activities in higher education, which has its contemporary creative sustainable development. Exclusive attention was paid to Poltava Pedagogical Institute as a leader of higher educational institutions during the rectorship of Ivan Ziaziun and the rector himself.
THE IDEA OF A TEACHER IN ACADEMICIAN IVAN ZIAZIUN’S PEDAGOGICAL HERITAGE
Authors: Andrushchenko Viktor 
Published: September 2021

The significance of I. Ziaziun’s educational heritage for the formation of the personality of a teacher of the XXI century is analyzed in the article. It is emphasized that the idea of a teacher is one of the main subjects of his pedagogical heritage, which the scientist gave almost all his time. The notion “teacher”, in accordance with I. Ziaziun’s ideas, has been defined. The role and personality of a teacher in world history from the ancient times to the modern period is revealed. The author focuses on the peculiarities of the attitude towards the teacher’s profession in Ukraine and its national cultural traditions in different historical periods, in particular during the epoch of Tsarism and Soviet power, which, in spite of everything, were presented to the world by the world’s leading teachers, world-class teachers and practitioners – N. Pirohov and K. Ushynskii, A. Makarenko and V. Sukhomlynskii. The sacrament remains not only their ingenious heritage, which is being studied today in the whole civilized world, but also how they could create a similar in context and in spite of the era in which they lived, experiencing its grandiose ups and no less grandiose falls. The situation in the pedagogical space of modern Ukraine, the peculiarities and problems of preparing a new teacher, which could find answers to the challenges of the era and realize them in daily educational practice, is described. The characteristics of the teacher of a new generation, successful and liberated from stereotypes, linguistically competent, a researcher, an innovator, etc. are determined.The views of I. Ziaziun on the academic teacher’s look, his professional qualities, their formation at the pedagogical university, etc. are determined by the author completely accordant to new approaches, which are initiated by the Law of Ukraine “On Education” (2017) and the Project “New Ukrainian School”.
MORAL AND AESTHETIC CULTURE OF A TEACHER IN LIFE AND PHILOSOPHICAL DIMENSION OF ACADEMICIAN IVAN ZIAZIUN
Authors: Vasianovych Hryhorii , Velykyi Roman 
Published: September 2021

The article analyzes the essence and peculiarities of the moral and aesthetic culture of the teacher personality. Comprehension of this problem is based on philosophical and pedagogical works of academic I. Ziaziun. In the article it is proven that the main idea of the scholar was the idea of cognition and self-cognition. The main components of the structure of the moral and aesthetic culture of the teacher personality – consciousness, relationships and pedagogical action were analyzed. The position and role of the moral and aesthetic culture in the educational activity of teachers were determined. The author proves that the teacher personality is the subject of a moral and aesthetic culture, since it is directly integrated with subordinate and coordinate relations of different types. The conclusion was made that in conditions of democratization and humanization of society priority is set on coordinate relations. Therefore, the ideas and principles of pedagogy of cooperation are consistently established. The defining characteristic of the moral and aesthetic culture of the teacher personality is pedagogical action. Its significance goes far beyond the boundaries of Ukrainian educational institutions and, according to academic I. Ziaziun, the progress of the whole society depends on it.
AESTHETIC INTELLIGENCE OF THE TEACHER IN THE CONTEXT OF PEDAGOGICS OF GOOD OF IVAN ZIAZIUN
Authors: Fediy Olga 
Published: September 2021

The article is dedicated to assessment and evaluation of the philosophical and aesthetic fundamentals of educator’s activity in the era of informational society. The set of fellow contradictions of the contemporary educational system is defined by the author: ultimate uncertainty of the major goal of the educational process alongside with the priorities of educational activity; professional overload of the teacher and lack of one’s attention in relation to the essence of the aesthetic and spiritual self- value of a child.Author of the article offers the effective approach towards addressing of the misbalance in relations between a pupil and modern school – by development of aesthetic intelligence of the educator. The aesthetic intelligence is defined by the scholar as the system-composing trait of an individual, which is mainly oriented on representation of the essential, emotional and spiritual, aesthetically-realized acceptance of the natural aesthetical individuality of a pupil by an educator. Additional emphasis in this context is put on the importance of the pupil’s individually-developed ability for emotionally sensed living of one’s school life.The conceptual basis of the phenomenon of aesthetic intelligence of an educator is investigated in the light of the paradigm of the pedagogics of good (as it is offered by Ivan Ziaziun). The conceptual analysis of the major approaches of Ivan Ziaziun in relation to defining of the major essence of aesthetical and substantial contents of the aesthetic feelings is conducted. The set of such feelings cerates the fertile background for the spiritual and aesthetic area of educator’s activity. In addition aesthetic feelings fulfill the logics of the pedagogical actions with their sense and in such manner, strengthen the power of such actions in the process of achievement of an excepted outcome from such educational activity.The aesthetic feelings create the background for the strong spiritual and intelligence-based relations between a Teacher and a Pupil. Actualization of the aesthetic both in the context of the educational process and in the process of formation of the aesthetic intelligence, has its step-by-step characteristics: aesthetic creates the background for finding the path to the soul of a pupil, supports aesthetic and emotional experience of all subjects of the educational process and funds the final success in the context of gaining the set of educational competences by a pupil. The knowledge base (informational awareness and related practical competences), which is gained by the pupil alongside with experiencing the aesthetic pleasure, its assessment and evaluation, feeling corresponding personal sensation, deep and engaging understanding etc., which takes its place in the school environment (characterized as psychologically comfortable and aesthetically-fulfilled one) has the further potential of achievement of the effect of desired replication and updated emotional experience.
FORMATION OF CONCEPTS OF PROFESSIONAL BALETMAYSTER IN THE CONTEXT OF DEVELOPMENT OF UKRAINIAN HOREOGRAPHIC EDUCATION
Authors: Blahova Tetyana 
Published: September 2021

The article analyzes the essential features of the profession of choreographer, substantiates the value of the artistic and pedagogical heritage of the outstanding Ukrainian choreographers of the 20th century in the development of choreographic education in Ukraine; their ballet master's works are summarized, leading tendencies of professional activity; A complex of innovative artistic and aesthetic principles of work in choreographic collectives is described.The ballet master's activity as a specific kind of artistic activity is interpreted as a complex multidimensional phenomenon in the field of professional choreography, which is embodied in the process of creative work with choreographic material. The diverse work of the well-known Ukrainian choreographers nourished the field of professional dance with scientific ideas and practical achievements, determined the strategies of its development, content, technologies, methods of work, becoming the driving force in the formation of theoretical and practical regulation of choreographic pedagogy. The retrospective of the ballet master's experience of Ukrainian choreographers allows us to generalize its specifics and determine the essential features and directions through the prism of creative activity of well-known representatives of this specialty. The content of the professional meanings of the Ukrainian choreographer combines a combination of the essential characteristics: of the philosophical and artistic position, individual choreographic handwriting, creative style, performing style, a set of expressive means. They are realized in different directions of activity. The well-known Ukrainian choreographers have substantially expanded the system of basic concepts of the choreography profession by synthesizing the achievements of several generations in the field of folk dance production, substantiating their authoritative technologies of his practical and theoretical generalization.