bluuebunny/crossref_metadata_2025_split huggingface dataset:
SAPHO-Syndrom
Authors: Klemm Philipp , Lange Uwe 
Published: March 2021

ZusammenfassungBeim SAPHO-Syndrom handelt es sich nicht um eine Entität, sondern um einen inhomogenen, nosologisch wie pathogenetisch heterogenen Symptomenkomplex. Klinisch imponieren subakute, rezidivierende und/oder chronische Krankheitsprozesse mit charakteristisch gemeinsamer Haut-Knochen-Assoziation („ski[n]bo[ne]-disease“). Die chronisch rekurrierende multifokale Osteomyelitis (CRMO) ist die häufigste „SAPHO“-Erkrankung im Jugend- und Adoleszentenalter. Im Erwachsenenalter ist die Spondarthritis hyperostotica pustulo-psoriatica mit der Trias palmoplantare Pustulose, sternokostoklavikuläre Hyperostose und ossifizierenden Wirbelsäulenmanifestationen am häufigsten und generell als „SAPHO“ bekannt. Zusätzlich gibt es jedoch abortive Krankheitsformen: das entzündliche Anterior-chest-wall-Syndrom, das sternoklavikuläre Hyperostosesyndrom, die Akne-CRMO und die Akne-Spondarthritis. Insgesamt heilen die SAPHO-Krankheitsfälle meist mit relativ günstiger Prognose aus, es gibt aber auch ungünstige Verläufe mit funktionellen Einschränkungen. Neben der typischen Klinik dienen Bildgebung (Röntgen, Szintigraphie, Magnetresonanztomographie) und/oder histologische Knochenbiopsieanalyse der Diagnosestellung. Die Therapie sollte interdisziplinär erfolgen. Eine Antibiose ist obsolet. Der vorliegende Artikel vermittelt einen Überblick über das SAPHO-Syndrom und eine klinisch-rheumatologische wie bildgebende Differenzierung sowie nosologische Klassifizierung von 35 Fällen bei Erstvorstellung.
Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient
Authors: Mosqueira Matias , Konietzny Roland , Andresen Carolin , Wang Chao , H.A. Fink Rainer 
Published: March 2021

AbstractCardiac excitation–contraction coupling and metabolic and signaling activities are centrally modulated by nitric oxide (NO), which is produced by one of three NO synthases (NOSs). Despite the significant role of NO in cardiac Ca2+ homeostasis regulation under different pathophysiological conditions, such as Duchenne muscular dystrophy (DMD), no precise method describes the production, source or effect of NO through two NO signaling pathways: soluble guanylate cyclase-protein kinase G (NO-sGC-PKG) and S-nitrosylation (SNO). Using a novel strategy involving isolated murine cardiomyocytes loaded with a copper-based dye highly specific for NO, we observed a single transient NO production signal after each electrical stimulation event. The NO transient signal started 67.5 ms after the beginning of Rhod-2 Ca2+ transient signal and lasted for approximately 430 ms. Specific NOS isoform blockers or NO scavengers significantly inhibited the NO transient, suggesting that wild-type (WT) cardiomyocytes produce nNOS-dependent NO transients. Conversely, NO transient in mdx cardiomyocyte, a mouse model of DMD, was dependent on inducible NOS (iNOS) and endothelial (eNOS). In a consecutive stimulation protocol, the nNOS-dependent NO transient in WT cardiomyocytes significantly reduced the next Ca2+ transient via NO-sGC-PKG. In mdx cardiomyocytes, this inhibitory effect was iNOS- and eNOS-dependent and occurred through the SNO pathway. Basal NO production was nNOS- and iNOS-dependent in WT cardiomyocytes and eNOS- and iNOS-dependent in mdx cardiomyocytes. These results showed cardiomyocyte produces NO isoform-dependent transients upon membrane depolarization at the millisecond time scale activating a specific signaling pathway to negatively modulate the subsequent Ca2+ transient.
Ghrelin peptide improves glial conditioned medium effects on neuronal differentiation of human adipose mesenchymal stem cells
Authors: Russo Cristina , Mannino Giuliana , Patanè Martina , Parrinello Nunziatina Laura , Pellitteri Rosalia , Stanzani Stefania , Giuffrida Rosario , Lo Furno Debora , Russo Antonella 
Published: March 2021

AbstractThe influences of ghrelin on neural differentiation of adipose-derived mesenchymal stem cells (ASCs) were investigated in this study. The expression of typical neuronal markers, such as protein gene product 9.5 (PGP9.5) and Microtubule Associated Protein 2 (MAP2), as well as glial Fibrillary Acid Protein (GFAP) as a glial marker was evaluated in ASCs in different conditions. In particular, 2 µM ghrelin was added to control ASCs and to ASCs undergoing neural differentiation. For this purpose, ASCs were cultured in Conditioned Media obtained from Olfactory Ensheathing cells (OEC-CM) or from Schwann cells (SC-CM). Data on marker expression were gathered after 1 and 7 days of culture by fluorescence immunocytochemistry and flow cytometry. Results show that only weak effects were induced by the addition of only ghrelin. Instead, dynamic ghrelin-induced modifications were detected on the increased marker expression elicited by glial conditioned media. In fact, the combination of ghrelin and conditioned media consistently induced a further increase of PGP9.5 and MAP2 expression, especially after 7 days of treatment. The combination of ghrelin with SC-CM produced the most evident effects. Weak or no modifications were found on conditioned medium-induced GFAP increases. Observations on the ghrelin receptor indicate that its expression in control ASCs, virtually unchanged by the addition of only ghrelin, was considerably increased by CM treatment. These increases were enhanced by combining ghrelin and CM treatment, especially at 7 days. Overall, it can be assumed that ghrelin favors a neuronal rather than a glial ASC differentiation.
Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
Authors: Yasar Zerbu , Elliott Bradley T. , Kyriakidou Yvoni , Nwokoma Chiazor T. , Postlethwaite Ruth D. , Gaffney Christopher J. , Dewhurst Susan , Hayes Lawrence D. 
Published: March 2021

Abstract
Purpose
The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men.

Methods
Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group.

Results
Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL−1 and 60 (12) pg mL−1, respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL−1 which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07).

Conclusion
Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest.
Comparative evaluation of cardiovascular risks among nine FDA-approved VEGFR-TKIs in patients with solid tumors: a Bayesian network analysis of randomized controlled trials
Authors: Hou Wanting , Ding Mingfu , Li Xiaohua , Zhou Xiaohan , Zhu Qing , Varela-Ramirez Armando , Yi Cheng 
Published: March 2021

Abstract
Purpose
The present meta-analysis study was performed to identify the potential cardiotoxicity risks when using Vascular Endothelial Growth Factor Receptor Tyrosine kinase inhibitors (VEGFR-TKIs) as anticancer drugs in patients with solid tumors.

Methods
Pubmed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases were searched for the randomized controlled trials. We have included 45 randomized controlled trials (RCTs) associated with nine VEGFR-TKIs Food and Drug Administration (FDA)-approved drugs used to treat patients with solid tumors. To evaluate the trials’ risk of bias, Cochrane Risk of Bias Tool was assessed. A direct comparison was assessed by RevMan5.3 software, calculating the odds ratio (OR) and 95% confidence interval (CI). Heterogeneity was tested by the I2 statistic and Chi-square test for P value. Bayesian network meta-analysis was performed using Stata 15.0 and GeMTC 0.14.3 software, calculated OR along with corresponding 95% credible interval (CrI). The model’s convergence was evaluated by the potential scale reduced factor (PSRF). Consistency between direct and indirect comparisons was assessed by the “node-splitting” method.

Results
In this network meta-analysis, a total of 20,027 patients from 45 randomized controlled trials and associated with nine FDA-approved VEGFR-TKIs (axitinib, cabozantinib, lenvatinib, nintedanib, pazopanib, regorafenib, sorafenib, sunitinib, vandetanib), were enrolled. Findings indicated that lenvatinib had the most significant probability of provoking all grades cardiovascular incident and hypertension, followed by vandetanib, cabozantinib, axitinib, pazopanib, sorafenib, sunitinib, regorafenib and nintedanib. The nine agent’s severe cardiovascular and severe hypertension risk was probably similar. The ranking probability of cardiac toxicity shows that vandetanib ranked most likely to have the highest risk for cardiotoxicity among all the VEGFR-TKIs reviewed, followed by pazopanib, axitinib, sorafenib, sunitinib. In contrast, regorafenib and nintedanib did not exhibit an increased risk of cardiac damage.

Conclusions
The association between the nine VEGFR-TKIs with potential cardiotoxicity occurrence was reviewed. Both the regorafenib and nintedanib did not display detectable signs of cardiotoxic damage. In contrast, lenvatinib and vandetanib are ranked to have the most severe cardiotoxicity side impacts. These results may provide information for clinical practice guidelines, implementing strategies in selecting the adequate VEGFR-TKIs, and understanding the cardiovascular toxicity inflicted by the VEGFR-TKIs.

PROSPERO identifier
CRD 42,020,167,307.
The dietary management of potassium in children with CKD stages 2–5 and on dialysis—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce
Authors: Desloovere An , Renken-Terhaerdt José , Tuokkola Jetta , Shaw Vanessa , Greenbaum Larry A. , Haffner Dieter , Anderson Caroline , Nelms Christina L. , Oosterveld Michiel J. S. , Paglialonga Fabio , Polderman Nonnie , Qizalbash Leila , Warady Bradley A. , Shroff Rukshana , Vande Walle Johan 
Published: March 2021

AbstractDyskalemias are often seen in children with chronic kidney disease (CKD). While hyperkalemia is common, with an increasing prevalence as glomerular filtration rate declines, hypokalemia may also occur, particularly in children with renal tubular disorders and those on intensive dialysis regimens. Dietary assessment and adjustment of potassium intake is critically important in children with CKD as hyperkalemia can be life-threatening. Manipulation of dietary potassium can be challenging as it may affect the intake of other nutrients and reduce palatability. The Pediatric Renal Nutrition Taskforce (PRNT), an international team of pediatric renal dietitians and pediatric nephrologists, has developed clinical practice recommendations (CPRs) for the dietary management of potassium in children with CKD stages 2–5 and on dialysis (CKD2–5D). We describe the assessment of dietary potassium intake, requirements for potassium in healthy children, and the dietary management of hypo- and hyperkalemia in children with CKD2–5D. Common potassium containing foods are described and approaches to adjusting potassium intake that can be incorporated into everyday practice discussed. Given the poor quality of evidence available, a Delphi survey was conducted to seek consensus from international experts. Statements with a low grade or those that are opinion-based must be carefully considered and adapted to individual patient needs, based on the clinical judgment of the treating physician and dietitian. These CPRs will be regularly audited and updated by the PRNT.
Acoustics on small scales
Authors: Toth Florian , Hassanpour Guilvaiee Hamideh , Jank Georg 
Published: March 2021

AbstractWe present a modelling strategy based on the finite element method to describe flexible, piezoelectric structures surrounded by a compressible fluid, including viscosity. Non-conforming interfaces based on the Mortar method are used to couple the different physical domains. Finally, we present an application example of a piezoelectrically actuated MEMS structure to illustrate the modeling procedure and the impact of viscous effects.
Association of early and later depressive symptoms with functional outcome after ischemic stroke
Authors: Lopatkiewicz Anna Maria , Pera Joanna , Slowik Agnieszka , Dziedzic Tomasz 
Published: March 2021

Abstract
Background
Post-stroke depressive symptoms (DS) can be chronic or transient, occurring shortly or long after stroke and lasting only few months. It remains unclear if the prognosis differs between patients with DS in the acute phase of stroke and those who develop DS several months later. We aimed to determine whether outcomes vary among patients with different trajectories of post-stroke depressive symptoms.

Methods
Of 698 enrolled patients with ischemic stroke, we included 335 participants (median age: 68, 48% female) who were assessed for DS both 8 days and 3 months post-stroke. We divided patients into 4 groups: without greater DS (Group 1), only earlier DS (Group 2), only later DS (Group 3), and persistent DS (Group 4). Logistic regression was used to determine the association between DS and 3- and 12-month functional outcome.

Results
Group 2 was predominantly female and had the highest rate of previous stroke or transient ischemic attack. Group 3 was more likely to suffer from delirium and more severe stroke. Group 4 had the highest frequency of vascular risk factors, pre-morbid psychiatric symptoms, and cognitive decline. In multivariate analysis, Group 3, but not Groups 2 and 4, had an increased risk of poor 3- and 12-month functional outcome (adjusted OR 2.59, 95% CI 1.64–4.07, P < 0.01 and OR 3.97, 95% CI 2.32–6.76, P < 0.01, respectively) compared with Group 1.

Conclusions
Different trajectories of post-stroke DS are related to different outcomes. Patients who only have later DS also have the worst prognosis.
Influence of various DEM shape representation methods on packing and shearing of granular assemblies
Authors: Soltanbeigi Behzad , Podlozhnyuk Alexander , Kloss Christoph , Pirker Stefan , Ooi Jin Y. , Papanicolopulos Stefanos-Aldo 
Published: March 2021

AbstractRealistic yet efficient representation of particle shape is a major challenge for the Discrete Element Method. This paper uses angle-of-repose and direct-shear test simulations to describe the influence of several shape representation methods, and their parameters, on the bulk response of granular assemblies. Three rolling resistance models, with varying coefficient of rolling friction, are considered for spherical particles. For non-spherical particles, superquadrics with varying blockiness and multi-spheres with varying bumpiness are used to model cuboids and cylinders of several aspect ratios. We present extensive quantitative results showing how the various ways used to represent shape affect the bulk response, allowing comparisons between different approaches. Simulations of angle-of-repose tests show that all three rolling friction models can model the avalanching characteristics of cube/cuboid and cylindrical particles. Simulations of direct-shear tests suggest that both the shear strength and the dilative response of the considered non-spherical particles (but not their porosity) can only be predicted by the elasto-plastic rolling resistance model. The quantitative nature of the results allows identifying values of the shape-description parameters that can be used to obtain similar results when using alternative shape representation methods.Graphical abstract
The outbreak of illegal gold mining in the Brazilian Amazon boosts deforestation
Authors: Siqueira-Gay Juliana , Sánchez Luis E. 
Published: March 2021

AbstractIncreased prices and political pressure are boosting illegal gold mining in the Brazilian Amazon, threatening forests, indigenous people, and conservation of biodiversity in protected areas. The rate of illegal mining deforestation increased more than 90% from 2017 to 2020, reaching 101.7 km2 annually in 2020 compared to 52.9 km2 annually in 2017. In that period, illegal mining deforestation rate grew more than the rate of clearing within mining leases. While formal mining is required to comply with environmental regulations, most small-scale or artisanal mining and especially illegal mining areas are abandoned after reserves are exhausted, without proper rehabilitation. Deforestation due to illegal mining is likely to increase in the next years, calling for coordination between local and regional policies as well as for strengthening and expanding international mechanisms to increase traceability of mineral supply chains with certification schemes to help to curb illegal mining.
The role of prosocial attitudes and academic achievement in peer networks in higher education
Authors: Brouwer Jasperina , Engels Maaike C. 
Published: March 2021

AbstractAfter the transition to university, students need to build a new peer network, which helps them to adapt to university life. This study investigated to what extent students’ prosocial attitudes and academic achievement facilitate the embeddedness in friendship and help-seeking networks, while taking structural network characteristics into account. Participants were 95 first-year bachelor’s degree students and were part of learning communities consisting of 12 students at a university in the Netherlands. Measures included student-reports of prosocial attitudes, peer nominations of friendship and help-seeking networks, and officially registered grades (GPA). Longitudinal social network analysis, stochastic actor-based modeling with the package RSiena, revealed that both students’ own prosocial attitudes and achievement played a role in their friendship formation, whereas only students’ own achievement made the formation of their help-seeking relationships more likely. When students were friends, it was more likely that they approached each other for help and vice versa. Similarity in achievement level contributed to relationship formation in friendship and help-seeking networks. Overall, the results underscore the importance of both student’ prosocial attitudes and achievement for their social adjustment (i.e., making friends) and only achievement for their academic adjustment (i.e., seeking help) during the first year of university within the context of small-scale teaching.
Das Handwerk zwischen Corona-Krise und Rückvermeisterung
Authors: Haverkamp Katarzyna , Runst Petrik , Proeger Till 
Published: March 2021

ZusammenfassungDas Handwerk zeigte vor der Corona-Krise eine sehr positive Geschäftslage. Im Verlauf der Krise kam es zur Überlagerung der Effekte der Lockdown-Maßnahmen und der Novellierung der Handwerksordnung, durch die zwölf Handwerke erneut meisterpflichtig wurden. Mit Hilfe der Daten der Handwerkskammern werden die Effekte beider Veränderungen auf die Betriebsdynamik analysiert. Die Ergebnisse zeigen, dass das Handwerk in der Krise bisher keinen strukturellen Schaden — d. h. einen Rückgang an Gründungen und einen Anstieg an Betriebsaufgaben — aufweist. Gleichzeitig wirkt sich die Re-Regulierung auf die Gründungsdynamik in den betroffenen Handwerken aus.
Inhärente Instabilität: zur Rolle der Output-Lücke im Stabilitäts- und Wachstumspakt
Authors: Bender Christian M. , Heise Arne 
Published: March 2021

ZusammenfassungFiskalregeln im Allgemeinen und der Stabilitäts- und Wachstumspakt im Speziellen werden wiederholt ins Feld geführt, um Staatsverschuldung effektiv zu begrenzen und fiskalische Nachhaltigkeit zu erzeugen. Besondere Aufmerksamkeit verdient hierbei das Konzept der unbeobachtbaren Output-Lücke.
Recharge response and kinematics of an unusual earthflow in Liechtenstein
Authors: Aaron Jordan , Loew Simon , Forrer Markus 
Published: March 2021

AbstractUnderstanding landslide behavior over medium and long timescales is crucial for predicting landslide hazard and constructing accurate landscape evolution models. The behavior of landslides in soil that undergo periodic displacements, termed earthflows or compound soil slides, is especially difficult to forecast at these timescales. This is because velocities can increase by orders of magnitude over annual to decadal timescales, due to processes such as changing recharge conditions, erosion of the landslide toe, and retrogression of the landslide head. In this paper, we provide a detailed analysis of the Schlucher landslide, an unusual earthflow that is perched above the village of Malbun, Liechtenstein. This landslide had been displacing by 10 to 20 cm/year until 2015, when displacements on the order of 2 m/year occurred from 2016 to 2018. These large displacements damaged landslide mitigation measures, caused numerous surface deformation features, and threatened the local population downstream of the earthflow. This landslide has an unusually long monitoring record, with accurate displacement and climatic data available since 1983. We analyze this nearly 40-year monitoring time series to estimate recharge from snowmelt and rainfall, and its correlation with displacement. We also analyze recently collected, high-resolution surface and subsurface data in order to understand landslide response to recharge, landslide kinematics through time, and catastrophic failure potential. We find that interannual displacements can be explained with variations in recharge; however, periodic surges with recurrence times of tens of years must be explained by other mechanisms. In particular, recharge into the landslide during the recent acceleration (2016 to 2018) was not anomalously high. Instead, we argue that loss of internal strength is responsible for this recent acceleration period, and that this mechanism should be considered when forecasting the surge potential for certain earthflows and soil slides.