bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC01207 is up-regulated in gastric cancer tissues and promotes disease progression by regulating miR-671-5p/DDX5 axis
Authors: Liu Hongquan , Liu Xiaoyu 
Published: April 2021

Abstract
LINC01207 is involved in the progression of some cancers. This study was designed to delve into the biological function and mechanism of LINC01207 in gastric cancer. Quantitative polymerase chain reaction (qPCR) was adopted to examine the expression levels of LINC01207, miR-671-5p, dead-box polypeptide 5 (DDX5) mRNA in gastric cancer tissues and cells. After LINC01207 was overexpressed or depleted, MTT and bromodeoxyuridine (BrdU) assays were conducted to detect cell proliferation. Transwell assay was employed to detect cell migration and invasion. Western blot was used to detect the expression of DDX5 protein in cells. Bioinformatics analysis, luciferase reporter assay and RNA pull-down assay were performed to predict and validate the binding site between miR-671-5p and LINC01207 or DDX5. LINC01207 and DDX5 mRNA were upregulated in gastric cancer, while miR-671-5p was downregulated; high expression of LINC01207 and transfection of miR-671-5p inhibitors facilitated the proliferation of gastric cancer cells; however, knocking down LINC01207 and the overexpression of miR-671-5p mimics had opposite biological effects. LINC01207 and miR-671-5p were interacted and miR-671-5p was negatively regulated by LINC01207. MiR-671-5p could reverse the function of LINC01207. DDX5 was a downstream target of miR-671-5p and was positively modulated by LINC01207. LINC01207 promotes the proliferation and metastasis of gastric cancer cells by regulating miR-671-5p/DDX5 axis.
SRPS–deep-learning-based photometric stereo using superresolution images
Authors: Song Euijeong , Kim Seokjung , Chung Seok , Chang Minho 
Published: April 2021

Abstract
This paper introduces a novel deep-learning-based photometric stereo method that uses superresolution (SR) images: SR photometric stereo. Recent deep-learning-based SR algorithms have yielded great results in terms of enlarging images without mosaic effects. Supposing that the SR algorithms successfully enhance the feature and colour information of original images, implementing SR images using the photometric stereo method facilitates the use of considerably more information on the object than existing photometric stereo methods. We built a novel deep-learning-based network for the photometric stereo technique to optimize the input–output of SR image inputs and normal map outputs. We tested our network using the most widely used benchmark dataset and obtained better results than existing photometric stereo methods.
Uncomfortably Numb: The Disconnect between Individual Human Rights Perceptions and State Human Rights Practices
Authors: Yates Tyler P 
Published: April 2021

Abstract:In this article I argue the average person does not have an accurate perception of their government’s human rights practices. Individuals are unable to accurately gauge their government’s human rights behaviours due to a conflation of indifference, personal biases, and focused reframing efforts by the government and other interested parties. This disconnect between state practice and individual perception creates an informational barrier for human rights activists and non-governmental organizations that threatens both their public support and their ability to meet objectives. I offer analysis of the above arguments by examining a survey question from the World Values Study that asks participants to rank their state’s human rights behaviour. I find that there is no direct correlation between these perceived rankings and the state s actual human rights practices. Further, I find that individuals living in states with higher existing levels of personal human rights are more likely to have a negative view of their state’s human rights performance. Finally, I find that individuals from states with a history of past political violence are more likely to demonstrate inflated perceptions of their state’s human rights practices. These findings elucidate the necessity for human rights organizations to take account of, and potentially combat, the disconnect between individuals’ human rights perceptions and states’ action when engaging in activism.
Using 2D dental geometric morphometrics to identify modernPerognathusandChaetodipusspecimens (Rodentia, Heteromyidae)
Authors: Wyatt Megan R , Hopkins Samantha S B , Davis Edward B 
Published: April 2021

AbstractThe Heteromyidae (pocket mice and kangaroo rats) are a group of extant small rodents abundant in western North America, as well as in fossil assemblages over the last 20 million years. Two genera of heteromyids, Chaetodipus and Perognathus, share similar tooth morphology and teeth are the primary fossil remains. Previous genetic studies show these extant sister genera likely diverged in the middle Miocene (~16 million years ago); however, the Chaetodipus fossil record starts in the Pleistocene (~2 million years ago). In this study, we asked whether two-dimensional geometric morphometrics on complete dentition and isolated premolars can accurately identify Chaetodipus and Perognathus specimens at the genus and species level. We landmarked the occlusal surface of the upper and lower tooth rows of modern Chaetodipus (n = 83) and Perognathus specimens (n = 80), including 12 of the 26 extant species across the two genera. We ran a canonical variates analysis to investigate whether principal component variation could predict known taxonomic identifications. The morphospace using complete dentition can identify specimens to genus with 90 – 92% accuracy and to species with more variable accuracy. We found an isolated premolar provides sufficient information for genus-level identification (69 – 84% accuracy), but not for species-level identification (26 – 56% accuracy). This morphospace of modern specimens can be used to identify the skeletal remains of Chaetodipus and Perognathus in museum collections, raptor pellets, or middens, to refine our existing knowledge of heteromyid evolutionary history.
Nonprofits: A Public Policy Tool for the Promotion of Community Subjective Well-being
Authors: Ressler Robert W , Paxton Pamela , Velasco Kristopher , Pivnick Lilla , Weiss Inbar , Eichstaedt Johannes C 
Published: April 2021

AbstractLooking to supplement common economic indicators, politicians and policymakers are increasingly interested in how to measure and improve the subjective well-being of communities. Theories about nonprofit organizations suggest that they represent a potential policy-amenable lever to increase community subjective well-being. Using longitudinal cross-lagged panel models with IRS and Twitter data, this study explores whether communities with higher numbers of nonprofits per capita exhibit greater subjective well-being in the form of more expressions of positive emotion, engagement, and relationships. We find associations, robust to sample bias concerns, between most types of nonprofit organizations and decreases in negative emotions, negative sentiments about relationships, and disengagement. We also find an association between nonprofit presence and the proportion of words tweeted in a county that indicate engagement. These findings contribute to our theoretical understanding of why nonprofit organizations matter for community-level outcomes and how they should be considered an important public policy lever.
Glucosamine attenuates drug resistance in Mitoxantrone-resistance breast cancer cells
Authors: Valinezhad Sani Fatemeh , Palizban Abbasali , Mosaffa Fatemeh , Jamialahmadi Khadijeh 
Published: April 2021

Abstract

Objectives
This study was aimed at investigating the cytotoxicity and multi-drug resistance (MDR) reversal effect of Glucosamine (GlcN) on resistant BCRP-overexpressing breast cancer MCF-7/MX cells.

Methods
After confirming the overexpression of BCRP, the cytotoxicity and MDR reversing potential of GlcN on MCF-7/MX mitoxantrone-resistant and MCF-7 sensitive breast cancer cells were assessed via MTT assay. The effects of GlcN on mitoxantrone accumulation were analyzed through flow cytometry. Finally, the expression of BCRP and Epithelial-Mesenchymal Transition (EMT)-related markers following the exposure to GlcN were assessed by real-time RT-PCR.

Key findings
This study showed that glucosamine had an inhibitory effect on the proliferation of human breast cancer cells. The respective IC50 values for MCF-7/MX cells following exposure to mitoxantrone (MX) in the presence of GlcN (0, 0.5 and 1 mm) for 72 h were 3.61 ± 0.21, 0.598 ± 0.041 and 0.284 ± 0.016 μm, respectively. Furthermore, GlcN reduced the expression of BCRP mRNA without any significant effect on EMT-related markers in breast cancer cells.

Conclusions
These results proposed that glucosamine as a natural sugar could down regulate the BCRP expression and increased MX cytotoxicity in breast cancer cells.
1,8-cineole ameliorates ischaemic brain damage via TRPC6/CREB pathways in rats
Authors: Meng Chen , Zeng Wenjing , Lv Jing , Wang Yu , Gao Meiling , Chang Ruijie , Li Qing , Wang Xianyu 
Published: April 2021

Abstract

Objectives
A previous in vitro study reported that the monoterpene oxide 1,8-cineole (cineole) attenuates neuronal caused by oxygen–glucose deprivation/reoxygenation in culture. However, to date, there is no in vivo evidence showing neuroprotective effects of cineole against stroke. This study aimed to investigate whether cineole attenuates cerebral ischaemic damage in rats.

Methods
A rat model of middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion was applied. Male rats were treated with oral cineole (100 mg/kg) for 7 consecutive days, then subjected to MCAO surgery. Infarct volume, neurologic deficits, apoptosis and expression levels of all-spectrin breakdown products of 145 kDa (SBDP145), transient receptor potential canonical (subtype) 6 (TRPC6) and phosphorylated CREB (p-CREB) were measured in ischaemic brain tissues.

Key findings
Cineole treatment significantly reduced infarct volume, neurological dysfunction, neuronal apoptosis, SBDP145 formation and TRPC6 degradation and enhanced p-CREB expression in MCAO rats compared with vehicle treatment. These neuroprotective effects were markedly suppressed by pharmacological inhibition of MEK or CaMKIV signalling.

Conclusions
Our study provides in vivo evidence demonstrating that cineole pretreatment attenuates ischaemic stroke-induced brain damage, mainly through blocking calpain-induced TRPC6 degradation and activating CREB via MEK/CREB and CaMKIV/CREB signalling pathways.
Curious Conversations: Henry Mayhew and the Street-Sellers in the Media Ecology of London Labour and the London Poor
Authors: Herdman Jenna M 
Published: April 2021

Abstract
Henry Mayhew is renowned as the chronicler and historian of London street-sellers and poor labourers. However, Mayhew’s relationships with his subjects, and their influence on the development of London Labour and the London Poor, is less often discussed. This article examines Mayhew’s productive and disruptive friendships, collaborations, and disagreements with the London poor, and situates these exchanges within the layered print and oral texts that comprise the extensive media ecology of London Labour. I argue that through their disruptive collaborations with Mayhew, some street-sellers, including Charles Alloway, memorialized as ‘The Crippled Street-Seller of Nut-Meg Graters’, strategically harnessed the media forms of London Labour for profitable self-representation. In contrast, a group of street-sellers known as the Street Traders’ Protection Association mobilized against Mayhew and critiqued his representations of their class. These disruptive collaborations reveal underlying kinships and conflicts between Mayhew and the street-folk, thus destabilizing his reputation as a neutral and authoritative observer in the history of poverty.
Magellanic satellites in ΛCDM cosmological hydrodynamical simulations of the Local Group
Authors: Santos-Santos Isabel M E , Fattahi Azadeh , Sales Laura V , Navarro Julio F 
Published: April 2021

ABSTRACT
We use the APOSTLE ΛCDM cosmological hydrodynamical simulations of the Local Group to study the recent accretion of massive satellites into the halo of Milky Way (MW)-sized galaxies. These systems are selected to be close analogues to the Large Magellanic Cloud (LMC), the most massive satellite of the MW. The simulations allow us to address, in a cosmological context, the impact of the Clouds on the MW, including the contribution of Magellanic satellites to the MW satellite population, and the constraints placed on the Galactic potential by the motion of the LMC. We show that LMC-like satellites are twice more common around Local Group-like primaries than around isolated haloes of similar mass; these satellites come from large turnaround radii and are on highly eccentric orbits whose velocities at first pericentre are comparable with the primary’s escape velocity. This implies $V_{\rm esc}^{\rm MW} (50$ kpc) ∼ 365 km s−1, a strong constraint on Galactic potential models. LMC analogues contribute about two satellites with $M_*\gt 10^5\, \mathrm{ M}_\odot$, having thus only a mild impact on the luminous satellite population of their hosts. At first pericentre, LMC-associated satellites are close to the LMC in position and velocity, and are distributed along the LMC’s orbital plane. Their orbital angular momenta roughly align with the LMC’s, but, interestingly, they may appear to ‘counter-rotate’ the MW in some cases. These criteria refine earlier estimates of the LMC association of MW satellites: only the SMC, Hydrus1, Car3, Hor1, Tuc4, Ret2, and Phoenix2 are compatible with all criteria. Carina, Grus2, Hor2, and Fornax are less probable associates given their large LMC relative velocity.
I – A hydrodynamical clone of the Virgo cluster of galaxies to confirm observationally driven formation scenarios
Authors: Sorce Jenny G , Dubois Yohan , Blaizot Jérémy , McGee Sean L , Yepes Gustavo , Knebe Alexander 
Published: April 2021

ABSTRACT
At ∼16–17 Mpc from us, the Virgo cluster is a formidable source of information to study cluster formation and galaxy evolution in rich environments. Several observationally driven formation scenarios arose within the past decade to explain the properties of galaxies that entered the cluster recently and the nature of the last significant merger that the cluster underwent. Confirming these scenarios requires extremely faithful numerical counterparts of the cluster. This paper presents the first clone, Constrained LOcal and Nesting Environment, simulation of the Virgo cluster within a ∼15 Mpc radius sphere. This cosmological hydrodynamical simulation, with feedback from supernovae and active galactic nuclei, with a ∼3 × 107 M⊙ dark matter particle mass and a minimum cell size of 350 pc in the zoom region, reproduces Virgo within its large-scale environment unlike a random cluster simulation. Overall the distribution of the simulated galaxy population matches the observed one including M87. The simulated cluster formation reveals exquisite agreements with observationally driven scenarios: within the last Gyr, about 300 small galaxies (M* &gt; 107 M⊙) entered the cluster, most of them within the last 500 Myr. The last significant merger event occurred about 2 Gyr ago: a group with a tenth of the mass of today’s cluster entered from the far side as viewed from the Milky Way. This excellent numerical replica of Virgo will permit studying different galaxy type evolution (jellyfish, backsplash, etc.) as well as feedback phenomena in the cluster core via unbiased comparisons between simulated and observed galaxies and hot gas phase profiles to understand this great physics laboratory.
The SLUGGS survey: combining stars, globular clusters, and planetary nebulae to understand the assembly history of early-type galaxies from their large radii kinematics
Authors: Dolfi Arianna , Forbes Duncan A , Couch Warrick J , Bekki Kenji , Ferré-Mateu Anna , Romanowsky Aaron J , Brodie Jean P 
Published: April 2021

ABSTRACT
We investigate the kinematic properties of nine nearby early-type galaxies with evidence of a disc-like component. Three of these galaxies are located in the field, five in the group, and only one in the cluster environment. By combining the kinematics of the stars with those of the globular clusters (GCs) and planetary nebulae (PNe), we probe the outer regions of our galaxies out to $\sim 4\!-\!6\, R_{\mathrm{e}}$. Six galaxies have PNe and red GCs that show good kinematic alignment with the stars, whose rotation occurs along the photometric major-axis of the galaxies, suggesting that both the PNe and red GCs are good tracers of the underlying stellar population beyond that traced by the stars. Additionally, the blue GCs also show rotation that is overall consistent with that of the red GCs in these six galaxies. The remaining three galaxies show kinematic twists and misalignment of the PNe and GCs with respect to the underlying stars, suggesting recent galaxy interactions. From the comparison with simulations, we propose that all six aligned galaxies that show similar dispersion-dominated kinematics at large radii ($\gt 2\!-\!3\, R_{\mathrm{e}}$) had similar late (z ≲ 1) assembly histories characterized by mini mergers (mass-ratio &lt; 1:10). The different Vrot/σ profiles are then the result of an early (z &gt; 1) minor merger (1:10 &lt; mass-ratio &lt; 1:4) for the four galaxies with peaked and decreasing Vrot/σ profiles and of a late minor merger for the two galaxies with flat Vrot/σ profiles. The three misaligned galaxies likely formed through multiple late minor mergers that enhanced their velocity dispersion at all radii, or a late major merger that spun-up both the GC subpopulations at large radii. Therefore, lenticular galaxies can have complex merger histories that shape their characteristic kinematic profile shapes.
The tidal stream generated by the globular cluster NGC 3201
Authors: Palau Carles G , Miralda-Escudé Jordi 
Published: April 2021

ABSTRACT
We detect a tidal stream generated by the globular cluster NGC 3201 extending over ∼140 deg on the sky, using the Gaia DR2 data, with the maximum-likelihood method we presented previously to study the M68 tidal stream. Most of the detected stream is the trailing one, which stretches in the southern Galactic hemisphere and passes within a close distance of 3.2 kpc from the Sun, therefore making the stream highly favourable for discovering relatively bright member stars, while the leading arm is further from us and behind a disc foreground that is harder to separate from. The cluster has just crossed the Galactic disc and is now in the northern Galactic hemisphere, moderately obscured by dust, and the part of the trailing tail closest to the cluster is highly obscured behind the plane. We obtain a best-fitting model of the stream which is consistent with the measured proper motion, radial velocity, and distance to NGC 3201, and show it to be the same as the previously detected Gjöll stream by Ibata et al. We identify ∼200 stars with the highest likelihood of being stream members using only their Gaia kinematic data. Most of these stars (170) are photometrically consistent with being members of NGC 3201 when they are compared to the cluster H–R diagram, only once a correction for dust absorption and reddening by the Galaxy is applied. The remaining stars are consistent with being random foreground objects according to simulated data sets. We list these 170 highly likely stream member stars.
The spectra of IceCube neutrino candidate sources – I. Optical spectroscopy of blazars
Authors: Paiano Simona , Falomo Renato , Treves Aldo , Padovani Paolo , Giommi Paolo , Scarpa Riccardo 
Published: April 2021

ABSTRACT
There is mounting evidence that ultra-energetic neutrinos of astrophysical origin may be associated with blazars. Here, we investigate a unique sample of 47 blazars, ∼20 of which could be new neutrino sources. In particular, we focus on 17 objects of yet unknown redshift, for which we present optical spectroscopy secured at the Gran Telescopio Canarias and the ESO Very Large Telescope. We find all sources but one (a quasar) to be BL Lac objects. For nine targets we are able to determine the redshift (0.09 &lt; z &lt; 1.6), while for the others we set a lower limit on it, based on either the robust detection of intervening absorption systems or on an estimation derived from the absence of spectral signatures of the host galaxy. In some spectra, we detect forbidden and semiforbidden emission lines with luminosities in the range 1040–1041 erg s−1. We also report on the spectroscopy of seven blazars possibly associated with energetic neutrinos that partially meet the criteria of our sample and are discussed in the Appendix. These results represent the starting point of our investigation into the real nature of these objects and their likelihood of being neutrino emitters.
The Hi-GAL compact source catalogue – II. The 360° catalogue of clump physical properties
Authors: Elia Davide , Merello M , Molinari S , Schisano E , Zavagno A , Russeil D , Mège P , Martin P G , Olmi L , Pestalozzi M , Plume R , Ragan S E , Benedettini M , Eden D J , Moore T J T , Noriega-Crespo A , Paladini R , Palmeirim P , Pezzuto S , Pilbratt G L , Rygl K L J , Schilke P , Strafella F , Tan J C , Traficante A , Baldeschi A , Bally J , Giorgio A M di , Fiorellino E , Liu S J , Piazzo L , Polychroni D 
Published: April 2021

ABSTRACT
We present the 360° catalogue of physical properties of Hi-GAL compact sources, detected between 70 and 500 $\mu$m. This release not only completes the analogous catalogue previously produced by the Hi-GAL collaboration for −71° ≲ ℓ ≲ 67°, but also meaningfully improves it because of a new set of heliocentric distances, 120 808 in total. About a third of the 150 223 entries are located in the newly added portion of the Galactic plane. A first classification based on detection at 70 $\mu$m as a signature of ongoing star-forming activity distinguishes between protostellar sources (23 per cent of the total) and starless sources, with the latter further classified as gravitationally bound (pre-stellar) or unbound. The integral of the spectral energy distribution, including ancillary photometry from λ = 21 to 1100 $\mu$m, gives the source luminosity and other bolometric quantities, while a modified blackbody fitted to data for $\lambda \ge 160~\mu$m yields mass and temperature. All tabulated clump properties are then derived using photometry and heliocentric distance, where possible. Statistics of these quantities are discussed with respect to both source Galactic location and evolutionary stage. No strong differences in the distributions of evolutionary indicators are found between the inner and outer Galaxy. However, masses and densities in the inner Galaxy are on average significantly larger, resulting in a higher number of clumps that are candidates to host massive star formation. Median behaviour of distance-independent parameters tracing source evolutionary status is examined as a function of the Galactocentric radius, showing no clear evidence of correlation with spiral arm positions.