bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal scenario of criticality for electroweak scale, neutrino masses, dark matter, and inflation
Authors: Hamada Yuta , Kawai Hikaru , Kawana Kiyoharu , Oda Kin-ya , Yagyu Kei 
Published: November 2021

AbstractWe propose a minimal model that can explain the electroweak scale, neutrino masses, Dark Matter (DM), and successful inflation all at once based on the multicritical-point principle (MPP). The model has two singlet scalar fields that realize an analogue of the Coleman–Weinberg mechanism, in addition to the Standard Model with heavy Majorana right-handed neutrinos. By assuming a $$Z_2 $$

Z
2

symmetry, one of the scalars becomes a DM candidate whose property is almost the same as the minimal Higgs-portal scalar DM. In this model, the MPP can naturally realize a saddle point in the Higgs potential at high energy scales. By the renormalization-group analysis, we study the critical Higgs inflation with non-minimal coupling $$\xi |H|^2 R$$

ξ
|
H
|

2

R

that utilizes the saddle point of the Higgs potential. We find that it is possible to realize successful inflation even for $$\xi =25$$

ξ
=
25

and that the heaviest right-handed neutrino is predicted to have a mass around $$10^{14}$$

10
14

$$\mathrm{GeV}$$
GeV
to meet the current cosmological observations. Such a small value of $$\xi $$
ξ
can be realized by the Higgs-portal coupling $$\lambda _{SH}\simeq 0.32$$

λ

SH

≃
0.32

and the vacuum expectation value of the additional neutral scalar $$\langle \phi \rangle \simeq 2.7$$

⟨
ϕ
⟩
≃
2.7

TeV, which correspond to the dark matter mass 2.0 TeV, its spin-independent cross section $$1.8\times 10^{-9}$$

1.8
×

10

-
9

pb, and the mass of additional neutral scalar 190 GeV.
Cold atmospheric plasma technology for removal of organic micropollutants from wastewater—a review
Authors: Kumar Amit , Škoro Nikola , Gernjak Wolfgang , Puač Nevena 
Published: November 2021

Abstract
Water bodies are being contaminated daily due to industrial, agricultural and domestic effluents. In the last decades, harmful organic micropollutants (OMPs) have been detected in surface and groundwater at low concentrations due to the discharge of untreated effluent in natural water bodies. As a consequence, aquatic life and public health are endangered. Unfortunately, traditional water treatment methods are ineffective in the degradation of most OMPs. In recent years, advanced oxidation processes (AOPs) techniques have received extensive attention for the mineralization of OMPs in water in order to avoid serious environmental problems. Cold atmospheric plasma discharge-based AOPs have been proven a promising technology for the degradation of non-biodegradable organic substances like OMPs. This paper reviews a wide range of cold atmospheric plasma sources with their reactor configurations used for the degradation of OMPs (such as organic dyes, pharmaceuticals, and pesticides) in wastewater. The role of plasma and treatment parameters (e.g. input power, voltage, working gas, treatment time, OMPs concentrations, etc.) on the oxidation of various OMPs are discussed. Furthermore, the degradation kinetics, intermediates compounds formed by plasma, and the synergetic effect of plasma in combination with a catalyst are also reported in this review.

GraphicAbstract
Plasticine: A Cross-layer Approximation Methodology for Multi-kernel Applications through Minimally Biased, High-throughput, and Energy-efficient SIMD Soft Multiplier-divider
Authors: Ebrahimi Zahra , Klar Dennis , Ekhtiyar Mohammad Aasim , Kumar Akash 
Published: November 2021

The rapid evolution of error-resilient programs intertwined with their quest for high throughput has motivated the use of Single Instruction, Multiple Data (SIMD) components in Field-Programmable Gate Arrays (FPGAs). Particularly, to exploit the error-resiliency of such applications,
Cross-layer
approximation paradigm has recently gained traction, the ultimate goal of which is to efficiently exploit approximation potentials across layers of abstraction. From circuit- to application-level, valuable studies have proposed various approximation techniques, albeit linked to four drawbacks: First, most of approximate multipliers and dividers operate only in SISD mode. Second, imprecise units are often substituted, merely in a single kernel of a multi-kernel application, with an
end-to-end
analysis in Quality of Results (QoR) and not in the gained performance. Third, state-of-the-art (SoA) strategies neglect the fact that each kernel contributes differently to the end-to-end QoR and performance metrics. Therefore, they lack in adopting a generic methodology for adjusting the approximation knobs to maximize performance gains for a user-defined quality constraint. Finally, multi-level techniques lack in being efficiently supported, from application-, to architecture-, to circuit-level, in a cohesive cross-layer hierarchy.

In this article, we propose
Plasticine
, a cross-layer methodology for multi-kernel applications, which addresses the aforementioned challenges by efficiently utilizing the synergistic effects of a chain of techniques across layers of abstraction. To this end, we propose an application sensitivity analysis and a heuristic that tailor the precision at constituent kernels of the application by finding the most tolerable degree of approximations for each of consecutive kernels, while also satisfying the ultimate user-defined QoR. The chain of approximations is also effectively enabled in a cross-layer hierarchy, from application- to architecture- to circuit-level, through the plasticity of SIMD multiplier-dividers, each supporting dynamic precision variability along with hybrid functionality. The end-to-end evaluations of Plasticine on three multi-kernel applications employed in bio-signal processing, image processing, and moving object tracking for Unmanned Air Vehicles (UAV) demonstrate 41%–64%, 39%–62%, and 70%–86% improvements in area, latency, and Area-Delay-Product (ADP), respectively, over 32-bit fixed precision, with negligible loss in QoR. To springboard future research in reconfigurable and approximate computing communities, our implementations will be available and open-sourced at https://cfaed.tu-dresden.de/pd-downloads.
Anticoagulation Treatment and Outcomes of Venous Thromboembolism by Weight and Body Mass Index: Insights From the Veterans Health Administration
Authors: Perino Alexander C. , Fan Jun , Schmitt Susan , Guo Jennifer D. , Hlavacek Patrick , Din Natasha , Kothari Mitra , Pundi Krishna , Russ Cristina , Emir Birol , Turakhia Mintu P. 
Published: November 2021

Background:

Consensus statements have recommended against the use of direct oral anticoagulants (DOACs) in venous thromboembolism (VTE) for patients ≥120 kg and ≥40 kg/m
2
. We sought to determine use and outcomes of DOACs for VTE across weight and body mass index (BMI).

Methods:
We performed a retrospective cohort study of patients with first-time VTE 2013 to 2018 that were treated with DOAC or warfarin in the Veterans Health Administration. The Veterans Health Administration has implemented system-wide guidance for patient selection and shared decision-making for use of DOACs in VTE at extremes of weight. We stratified patients by weight and BMI and assessed (1) association of weight and BMI category to outcomes in those prescribed DOAC; and (2) association of DOAC, as compared to warfarin, to outcomes by weight and BMI categories. Outcomes of interest included major bleeding, clinically relevant nonmajor bleeding, and recurrent VTE.

Results:

The analysis cohort included 51 871 patients prescribed DOAC or warfarin within 30 days of index VTE diagnosis (age 64.5±13.1 years; 6.0% female; median weight 93.4 kg [25th–75th: 80.5–108.6 kg]). For patients ≥120 kg (N=6934 patients), 38.4% were treated with DOAC, as compared to 45.4% of those ≥60 to <100 kg (N=30 645;
P
<0.0001). DOAC prescription was not associated with major bleeds, clinically relevant nonmajor bleeds, or recurrent VTE for those in higher weight and BMI categories as compared to those in average weight and BMI categories. DOAC prescription, as compared to warfarin, was not associated with increased recurrent VTE in any weight or BMI category.

Conclusions:

Patients ≥120 kg and ≥40 kg/m
2
with VTE are frequently prescribed DOAC by the Veterans Health Administration, without an increase in bleeding or recurrent VTE. These findings suggest DOACs can be safe and effective in this population and may argue for broader adoption of pharmacy policies that promote careful patient selection and shared decision making.
Impact of Stratification Mechanisms on Turbulent Characteristics of Stable Open-Channel Flows
Authors: Xiao Cheng-Nian , Senocak Inanc 
Published: November 2021

Abstract
Flow over a surface can be stratified by imposing a fixed mean vertical temperature (density) gradient profile throughout or via cooling at the surface. These distinct mechanisms can act simultaneously to establish a stable stratification in a flow. Here, we perform a series of direct numerical simulations of open-channel flows to study adaptation of a neutrally stratified turbulent flow under the combined or independent action of the aforementioned mechanisms. We force the fully developed flow with a constant mass flow rate. This flow forcing technique enables us to keep the bulk Reynolds number constant throughout our investigation and avoid complications arising from the acceleration of the bulk flow if a constant pressure gradient approach were to be adopted to force the flow instead. When both stratification mechanisms are active, the dimensionless stratification perturbation number emerges as an external flow control parameter, in addition to the Reynolds, Froude, and Prandtl numbers. We demonstrate that significant deviations from the Monin–Obukhov similarity formulation are possible when both types of stratification mechanisms are active within an otherwise weakly stable flow, even when the flux Richardson number is well below 0.2. An extended version of the similarity theory due to Zilitinkevich and Calanca shows promise in predicting the dimensionless shear for cases where both types of stratification mechanisms are active, but the extended theory is less accurate for gradients of scalar. The degree of deviation from neutral dimensionless shear as a function of the vertical coordinate emerges as a qualitative measure of the strength of stable stratification for all the cases investigated in this study.
Mesoscale Predictability in Moist Midlatitude Cyclones Is Not Sensitive to the Slope of the Background Kinetic Energy Spectrum
Authors: Lloveras Daniel J. , Tierney Lydia H. , Durran Dale R. 
Published: November 2021

Abstract
We investigate the sensitivity of mesoscale atmospheric predictability to the slope of the background kinetic energy spectrum E by adding initial errors to simulations of idealized moist midlatitude cyclones at several wavenumbers k for which the slope of E(k) is significantly different. These different slopes arise from 1) differences in the E(k) generated by cyclones growing in two different moist baroclinically unstable environments, and 2) differences in the horizontal scale at which initial perturbations are added, with E(k) having steeper slopes at larger scales. When small-amplitude potential temperature perturbations are added, the error growth through the subsequent 36-h simulation is not sensitive to the slope of E(k) nor to the horizontal scale of the initial error. In all cases with small-amplitude perturbations, the error growth in physical space is dominated by moist convection along frontal boundaries. As such, the error field is localized in physical space and broad in wavenumber (spectral) space. In moist midlatitude cyclones, these broadly distributed errors in wavenumber space limit mesoscale predictability by growing up-amplitude rather than by cascading upscale to progressively longer wavelengths. In contrast, the error distribution in homogeneous turbulence is broad in physical space and localized in wavenumber space, and dimensional analysis can be used to estimate the error growth rate at a specific wavenumber k from E(k). Predictability estimates derived in this manner, and from the numerical solutions of idealized models of homogeneous turbulence, depend on whether the slope of E(k) is shallower or steeper than k−3, which differs from the slope-insensitive behavior exhibited by moist midlatitude cyclones.
Trends in Precancerous Cervical Lesions by Area-Based Measures of Poverty, Race, and Ethnicity, Connecticut, 2008-2018
Authors: Brackney Monica M. , Weinberger Daniel M. , Higgins Kyle , Meek James , Niccolai Linda M. 
Published: November 2021

Objectives Trends in the incidence of precancerous cervical lesions can be monitored to evaluate the impact of human papillomavirus (HPV) vaccination. The objective of this analysis was to determine whether declines in precancerous cervical lesions varied by area-based measures of poverty, race, and ethnicity. Methods We analyzed 11 years of incidence data (2008-2018) from a statewide active surveillance system of precancerous cervical lesions in Connecticut. We divided area-based measures of poverty, race, and ethnicity (percentage of the population in a census tract who were living below the federal poverty level, who were Black, and who were Hispanic) at the census-tract level into 4 groups (<5.0%, 5.0%-9.9%, 10.0%-19.9%, ≥20.0%) using recommended cut points from the Public Health Disparities Geocoding Project. We estimated incidence rates and average annual percentage changes (AAPCs) stratified by age and each area-based measure using Joinpoint regression software. We used total population and estimated screened population as denominators for each age group to calculate rates and AAPCs. Results During 2008-2018 in Connecticut, 18 878 women aged 21-39 were diagnosed with precancerous cervical lesions. After adjusting for screening, the largest declines occurred among women aged 21-24 (AAPC = −11.5%; 95% CI, −13.6% to −9.4%). We found significant and similar annual declines (~10%-12%) in this age group across all 4 levels of poverty, race, and ethnicity. Conclusions This analysis adds to the growing body of evidence demonstrating the positive impact of population-level HPV vaccination among young women that appears similar across area-based measures of sociodemographic characteristics. Monitoring is necessary to ensure the continuation of this progress in all communities.
Does it matter whether we or I talk about us? Distinguishing we-talk in couples’ conflict discussions and partners’ private thoughts before and after conflict
Authors: Wilson Stephanie J. , Jaremka Lisa M. , Fagundes Christopher P. , Andridge Rebecca , Kiecolt-Glaser Janice K. 
Published: November 2021

According to extensive evidence, we-talk—couples’ use of first-person, plural pronouns—predicts better relationship quality and well-being. However, prior work has not distinguished we-talk by its context, which varies widely across studies. Also, little is known about we-talk’s consistency over time. To assess the stability and correlates of we-talk in private versus conversational contexts, 43 married couples’ language was captured during a marital problem discussion and in each partner’s privately recorded thoughts before and after conflict. Participants were asked to describe any current thoughts and feelings in the baseline thought-listing and to focus on their reaction to the conflict itself in the post-conflict sample. Couples repeated this protocol at a second study visit, approximately 1 month later. We-talk in baseline and post-conflict thought-listings was largely uncorrelated with we-talk during conflict discussions, but each form of we-talk was consistent between the two study visits. Their correlates were also distinct: more we-talk during conflict was associated with less hostility during conflict, whereas more baseline we-talk predicted greater closeness in both partners, as well as lower vocally encoded arousal and more positive emotion word use in partners after conflict. These novel data reveal that we-talk can be meaningfully distinguished by its context—whether language is sampled from private thoughts or marital discussions, and whether the study procedure requests relationship talk. Taken together, these variants of we-talk may have unique implications for relationship function and well-being.
How a pediatric neuro-oncology unit was managed in Madrid during the first wave of the COVID-19 pandemic
Authors: Vila Rocio , Vázquez-Gómez Felisa , Fioravantti Victoria , García-Fernandez Miriam , Lassaletta Alvaro 
Published: November 2021

Introduction: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, infection prevention measures were enforced at our Pediatric Neuro-Oncology unit. Methods: A retrospective study analyzing patients booked in this unit during lockdown was performed to describe its performance. Results: There were 438 consultations for 123 patients (320 on-site/118 telephone). Eight new diagnoses were made, with one significant delay. Only one patient tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Delay in imaging testing occurred in 15 patients. Chemotherapy was delayed in one case. There were no delays in radiotherapy. Conclusions: Measures implemented were effective in minimizing the risk of COVID-19 infection, achieving continuity in diagnoses and treatment, and avoiding delays that could impact survival.
Associations of Irritability With Functional Connectivity of Amygdala and Nucleus Accumbens in Adolescents and Young Adults With ADHD
Authors: Mukherjee Prerona , Vilgis Veronika , Rhoads Shawn , Chahal Rajpreet , Fassbender Catherine , Leibenluft Ellen , Dixon J. Faye , Pakyurek Murat , van den Bos Wouter , Hinshaw Stephen P. , Guyer Amanda E. , Schweitzer Julie B. 
Published: November 2021

Objective Irritability is a common characteristic in ADHD. We examined whether dysfunction in neural connections supporting threat and reward processing was related to irritability in adolescents and young adults with ADHD. Method We used resting-state fMRI to assess connectivity of amygdala and nucleus accumbens seeds in those with ADHD ( n = 34) and an age- and gender-matched typically-developing comparison group ( n = 34). Results In those with ADHD, irritability was associated with atypical functional connectivity of both seed regions. Amygdala seeds showed greater connectivity with right inferior frontal gyrus and caudate/putamen, and less connectivity with precuneus. Nucleus accumbens seeds showed altered connectivity with middle temporal gyrus and precuneus. Conclusion The irritability-ADHD presentation is associated with atypical functional connectivity of reward and threat processing regions with cognitive control and emotion processing regions. These patterns provide novel evidence for irritability-associated neural underpinnings in adolescents and young adults with ADHD. The findings suggest cognitive and behavioral treatments that address response to reward, including omission of an expected reward and irritability, may be beneficial for ADHD.
Evaluation of a calculation model to estimate the impact of the COVID-19 pandemic lockdown on visual acuity in neovascular AMD
Authors: Stattin Martin , Haas Anna-Maria , Ahmed Daniel , Graf Alexandra , Krepler Katharina , Ansari-Shahrezaei Siamak 
Published: November 2021

Purpose A model was calculated during the first Austrian coronavirus disease-2019 (COVID-19) pandemic lockdown to estimate the effect of a short-term treatment interruption due to healthcare restrictions on visual acuity (VA) in neovascular age-related macular degeneration (nAMD). The model was compared to the real-life outcomes before treatment re-started. Methods Retrospective data-collection of 142 eyes in 142 patients receiving repeated intravitreal injections with anti-VEGF at a retina unit in Vienna in a personalized pro-re-nata regimen prior to the COVID-19 associated lockdown, when treatment was deferred between March 16 and May 4, 2020. During the lockdown, the preliminary data was integrated into pre-existing formulae based on the natural course of the disease in untreated eyes in the long term. Patients were re-scheduled and treated after gradually opening operating rooms. The calculation model was compared to the effective VA change. Results The model calculated an overall VA loss of 3.5 ± 0.8 letters early treatment diabetes retinopathy study (ETDRS) ( p < 0.001 [95% CI:3.3;3.6]) on average compared to 2.5 ± 6 letters ETDRS ( p < 0.001 [95% CI:1.5;3.5]) as measured with a mean treatment delay of 61 ± 14 days after previously scheduled appointments. The total difference between the model exercise and the real-life outcomes accounted for 1 ± 5.9 letters ETDRS ( p = 0.051 [95% CI: 0.1;1.9]). Conclusion The herein presented calculation model might not be suitable to estimate the effective VA loss correctly over time, although untreated eyes and eyes under therapy show similarities after short-term treatment interruption. However, this study demonstrated the potentially negative impact of the COVID-19 pandemic lockdown on patients compromised by nAMD.
Better late than never: initial experience of intra-arterial pulsed-urokinase-injection as a salvage therapy for refractory sudden sensorineural hearing loss
Authors: Cui Yang , Liang Wenzhao , Li Mengxue , Zhao Zhongyu , Jiang Xinzhao , Zhao Bingyang , Xu Zhongxin , Mang Jing 
Published: November 2021

Background and Purpose Cochlear vascular micro-thrombosis has been hypothesized as one of the pathogenic mechanisms for sudden sensorineural hearing loss (SSNHL) refractory to regular management. This study aimed to evaluate the feasibility and safety of intra-arterial pulsed-injection urokinase (IAPU) as a salvage therapy for SSNHL after the failure of conventional therapy. Methods We retrospectively reviewed our patient database to identify refractory SSNHL patients between November 2017 and July 2020. Study outcomes before and after the IAPU therapy were compared between IAPU and conventional therapy groups. Results Sixty-seven moderate-profound SSNHL patients (29 in IAUP group, 38 in control group) were included in this study. Compared to the control group, patients in the IAPU group showed more significant improvement in pure tone average (PTA) (34.2 ± 23.5 vs. 10.7 ± 13.1, p < 0.001) and degree of hearing recovery (total: 20.7% vs. 5.3%, partial: 24.1% vs. 10.5%, mild: 27.6% vs. 13.2% and non: 27.6% vs. 71.1%) 2 weeks after admission. In the IAPU group, a significant improvement of PTA (86.6 ± 11.5 vs. 54.6 ± 20.1 dB, p < 0.005) was observed on the first day after IAPU treatment. Conclusion In carefully selected SSNHL cases with a highly suspected vascular origin, IAPU is a safe and effective therapy when conventional treatments have failed. Despite the encouraging findings of our work, large studies are needed to better investigate the strengths and limitations of this salvage therapy.
Bröstrom Repair Review
Authors: Chiou Daniel , Morris Brandon , Waryasz Gregory 
Published: November 2021

Since its introduction in 1966, the Bröstrom repair has been the workhorse for the treatment of chronic ankle instability. The procedure has expanded with the advent of arthroscopy, ultrasound, and other techniques. Because chronic ankle sprains/instability pose a barrier to athletes who perform high-level activities for a living, discussions concerning postoperative recovery and return to play criteria are important. Here we present an update on the Bröstrom-Gould procedure from preoperative management to return to play. Level of Evidence: Level V