bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis
Authors: Fong Ka Man , Au Shek Yin , Ng George Wing Yiu 
Published: August 2021

AbstractTo assess the effect from individual component in combinations of steroid, ascorbic acid, and thiamine on outcomes in adults with sepsis and septic shock with component network meta-analysis (NMA). We searched PubMed, EMBASE, and the Cochrane Library Central Register of Controlled Trials from 1980 to March 2021 for randomized controlled trials (RCT) that studied the use of glucocorticoid, fludrocortisone, ascorbic acid, and thiamine in patients with sepsis and septic shock. Citations screening, study selection, data extraction, and risk of bias assessment were independently performed by two authors. The primary outcome was short-term mortality. Secondary outcomes were longer-term mortality, time to resolution of shock and duration of mechanical ventilation. Thirty-three RCTs including 9898 patients presented on short-term mortality. In additive component NMA, patients on ascorbic acid alone (RR 0.74, 95% CI 0.57–0.97) or the combination of glucocorticoid and fludrocortisone (RR 0.89, 95% CI 0.80–0.99) had lower short-term mortality, but only the latter was associated with improved long-term mortality (RR 0.89, 95% CI 0.82–0.98). The use of glucocorticoid or the combination of glucocorticoid, ascorbic acid and thiamine hastened resolution of shock. Component NMA showed glucocorticoid (MD − 0.96, 95% CI − 1.61 to − 0.30) but not ascorbic acid or thiamine shortened the time to resolution of shock. Glucocorticoid shortened the duration of mechanical ventilation (MD − 1.48, 95% CI − 2.43 to − 0.52). In adults with sepsis and septic shock, the combination of glucocorticoid and fludrocortisone improved short-term and longer-term mortality. Glucocorticoid shortened the time to resolution of shock and duration of mechanical ventilation. There was no strong evidence supporting the routine use of thiamine and ascorbic acid, but they were associated with minimal adverse effects.
Surgical cup placement affects the heating up of total joint hip replacements
Authors: Damm Philipp , Bender Alwina , Waldheim Vivian , Winkler Tobias , Duda Georg N. 
Published: August 2021

AbstractThe long-term success of highly effective total hip arthroplasty (THA) is mainly restricted by aseptic loosening, which is widely associated with friction between the head and cup liner. However, knowledge of the in vivo joint friction and resulting temperature increase is limited. Employing a novel combination of in vivo and in silico technologies, we analyzed the hypothesis that the intraoperatively defined implant orientation defines the individual joint roofing, friction and its associated temperature increase. A total of 38,000 in vivo activity trials from a special group of 10 subjects with instrumented THA implants with an identical material combination were analyzed and showed a significant link between implant orientation, joint kinematics, joint roofing and friction-induced temperature increase but surprisingly not with acting joint contact force magnitude. This combined in vivo and in silico analysis revealed that cup placement in relation to the stem is key to the in vivo joint friction and heating-up of THA. Thus, intraoperative placement, and not only articulating materials, should be the focus of further improvements, especially for young and more active patients.
Cdx2 regulates immune cell infiltration in the intestine
Authors: Chewchuk Simon , Jahan Sanzida , Lohnes David 
Published: August 2021

AbstractThe intestinal epithelium is a unique tissue, serving both as a barrier against pathogens and to conduct the end digestion and adsorption of nutrients. As regards the former, the intestinal epithelium contains a diverse repertoire of immune cells, including a variety of resident lymphocytes, macrophages and dendritic cells. These cells serve a number of roles including mitigation of infection and to stimulate regeneration in response to damage. The transcription factor Cdx2, and to a lesser extent Cdx1, plays essential roles in intestinal homeostasis, and acts as a context-dependent tumour suppressor in colorectal cancer. Deletion of Cdx2 from the murine intestinal epithelium leads to macrophage infiltration resulting in a chronic inflammatory response. However the mechanisms by which Cdx2 loss evokes this response are poorly understood. To better understand this relationship, we used a conditional mouse model lacking all intestinal Cdx function to identify potential target genes which may contribute to this inflammatory phenotype. One such candidate encodes the histocompatability complex protein H2-T3, which functions to regulate intestinal iCD8α lymphocyte activity. We found that Cdx2 occupies the H3-T3 promoter in vivo and directly regulates its expression via a Cdx response element. Loss of Cdx function leads to a rapid and pronounced attenuation of H2-T3, followed by a decrease in iCD8α cell number, an increase in macrophage infiltration and activation of pro-inflammatory cascades. These findings suggest a previously unrecognized role for Cdx in intestinal homeostasis through H2-T3-dependent regulation of iCD8α cells.
Quality of heavy metal-contaminated soil before and after column flushing with washing agents derived from municipal sewage sludge
Authors: Klik Barbara , Gusiatin Zygmunt M. , Kulikowska Dorota 
Published: August 2021

AbstractRemoval of heavy metals (HMs) from soil is a priority in soil washing/soil flushing. However, for further management of remediated soil, it should be characterized in detail. This study presents, for the first time, an evaluation of soil quality after column flushing with new-generation washing agents (WAs) recovered from municipal sewage sludge (dissolved organic matter, DOM; soluble humic-like substances, HLS; soluble humic substances, SHS) and Na2EDTA as a standard benchmark. Sandy loam soil was spiked with industrial levels of Cu, Pb and Zn, then flushed in a column reactor at two WA flow rates (0.5 and 1.0 ml/min). Soil quality was assessed by determining both physico-chemical (pH, total HMs and their mobility, soil organic matter, OM, humic substances, HS and their fractions, macroelements) and biological indicators (dehydrogenase activity, DHA; germination rate, GR; and inhibition factors for roots and shoots of Triticum aestivum). Total residual HMs contents and HMs contents in the mobile fraction were significantly lower in soil flushed at 1.0 ml/min than in soil flushed at 0.5 ml/min. With all WAs, the decrease in Cu content was larger than that of the other HMs, however this HM most effectively was removed with DOM. In contrast, Pb most effectively was removed by HLS and Na2EDTA, and DOM should not be used to remediate Pb-contaminated soil, due to its very low effectiveness. Flow rate did not appear to affect the fertilizing properties of the soil, DHA activity or soil toxicity indicators. Soil flushing with all SS_WAs increased OM, HS, and exchangeable P, K and Na content in remediated soils, but decreased exchangeable Ca content, and in most cases, exchangeable Mg content. Soil flushing substantially improved DHA activity and GR, but only slightly improved the shoot and root inhibition factors.
Bioconvective Reiner–Rivlin nanofluid flow over a rotating disk with Cattaneo–Christov flow heat flux and entropy generation analysis
Authors: Lv Yu-Pei , Gul Hina , Ramzan Muhammad , Chung Jae Dong , Bilal Muhammad 
Published: August 2021

AbstractThe non-Newtonian fluids possess captivating heat transfer applications in comparison to the Newtonian fluids. Here, a new type of non-Newtonian fluid named Reiner–Rivlin nanofluid flow over a rough rotating disk with Cattaneo–Christov (C–C) heat flux is studied in a permeable media. The stability of the nanoparticles is augmented by adding the gyrotactic microorganisms in the nanofluid. The concept of the envisaged model is improved by considering the influences of Arrhenius activation energy, chemical reaction, slip, and convective conditions at the boundary of the surface. The entropy generation is evaluated by employing the second law of thermodynamics. The succor of the Shooting scheme combined with the bvp4c MATLAB software is adapted for the solution of extremely nonlinear system of equations. The noteworthy impacts of the evolving parameters versus engaged fields are inspected through graphical illustrations. The outcomes show that for a strong material parameter of Reiner–Rivlin, temperature, and concentration profiles are enhanced. The behavior of Skin friction coefficients, local Nusselt number, Sherwood number, and local density number of motile microorganisms against the different estimates of emerging parameters are represented in tabular form. The authenticity of the intended model is tested by comparing the presented results in limiting form to an already published paper. A proper correlation between the two results is attained.
Ground and excited electronic structures of metal encapsulated nanocages: the cases of endohedral M@C20H20(M = K, Rb, Ca, Sr) and M@C36H36(M = Na, K, Rb)
Authors: Ariyarathna Isuru R. 
Published: August 2021

Group I and II metal atom encapsulated C20H20/C36H36 can be recognized as superatoms owing to the shapes of their molecular orbitals. This work discloses specific superatomic Aufbau models of M@C20H20 (M = K, Rb, Ca, Sr) and M@C36H36 (M = Na, K, Rb).
High performance 2D MXene based conducting polymer hybrids: synthesis to emerging applications
Authors: Faruk Omar , Ahmed Abbas , Adak Bapan , Marzana Maliha , Hossain Md. Milon , Mukhopadhyay Samrat 
Published: August 2021

This review highlights the recent advances in MXene-conducting polymer hybrids for wearable electronics (e.g., energy storage, pressure sensing, and EMI shielding, etc.). Furthermore, several future research trends have also been envisioned.
New-generation dust emission templates for star-forming galaxies
Authors: Boquien Médéric , Salim Samir 
Published: August 2021

Context. The infrared (IR) emission of dust heated by stars provides critical information for galaxy evolution studies. Unfortunately, observations are often limited to the mid-IR, making templates a necessity. Previously published templates were based on small samples of luminous galaxies, which are not necessarily representative of normal star-forming galaxies.
Aims. We constructed new-generation dust templates, including instrument-specific relations and software tools that facilitate the estimation of the total IR (TIR) luminosity as well as obscured and unobscured star formation rate (SFR) based on one or several fluxes up to z = 4. For the first time, the templates include a dependence on both TIR luminosity and the specific SFR (sSFR), thereby increasing their reliability and utility for a wide range of galaxies. We also provide formulae for calculating TIR luminosities and SFR from JWST F2100W observations at 0 < z ≲ 2.
Methods. Our templates are based on 2584 normal star-forming galaxies spanning a wide range of stellar mass and sSFR, including sSFRs typical at higher redshifts. IR spectra and properties were obtained using CIGALE and the physically motivated Draine & Li (2007, ApJ, 657, 810) dust models. The photometry from the GALEX-SDSS-WISE Legacy Catalog was supplemented with 2MASS and Herschel-ATLAS, up to 19 bands from FUV to 500 μm.
Results. The shape of the dust spectrum varies with TIR luminosity, but also independently with sSFR. Remarkably precise estimates of the dust luminosity are possible with a single band over the rest-frame 12−17 μm and 55−130 μm. We validate single-band estimates on diverse populations, including local luminous IR galaxies, and find no significant systematic errors. Using two or more bands simultaneously yields the unbiased estimation of the TIR luminosity, even of star-forming dwarfs.
Conclusions. We obtain fresh insights regarding the interplay between monochromatic IR luminosities, spectral shapes, and physical properties, and we constructed new templates and estimators of the dust luminosity and SFR. We provide software for generating templates and estimating these quantities based on 1−4 bands from WISE, JWST, Spitzer, and Herschel, up to z = 4.
Increasing the performance of a system by changing reliability
Authors: Babiş Claudiu , Dimitrescu Andrei , Alecusan Ana Maria , Babiş Marcela 
Published: August 2021

The evaluation of the performance of a mechanical system takes into account many factors, including those related to competitiveness, technology and reliability.
From the point of view of competitiveness, most companies use the same state-of-the-art information obtained either by applying their own research, development and innovation resources, or by purchasing technologies and patents from other companies or from the free market. Thus the resulting products, if not innovative products, are part of the same range.
The global technological level has reached a very high degree of development, using unconventional technologies with high precision, robots, advanced mechanical systems and assembly lines with high productivity as well as verification and control systems on manufacturing flow which makes production to be uniform.
Differences between manufacturers begin to appear when the degree of customer satisfaction changes, which is also found in the concept of reliability. Thus, the one who will find the technological solution with the same number of parts, but with a high reliability, will win the market.
The paper aims at a detailed study with direct reference to how to increase reliability at the design stage.
Kriterien der alkohol- und substanzbezogenen Störungen im ICD-11
Authors: Preuss Ulrich W. , Hoch Eva , Wei Mooi Wong Jessica 
Published: August 2021

ZUSAMMENFASSUNGDie ICD-10-Kriterien für alkohol- und substanzbezogene Abhängigkeit und schädlichen Gebrauch sind seit 1991 gültig. Ziele des Reviews sind, die Änderungen und Erweiterungen der Diagnosen zu substanzbezogenen Störungen im ICD-11 (International Classification of Diseases Version 11) am Beispiel der Alkoholkonsumstörungen zu erläutern sowie Gemeinsamkeiten und Unterschiede zum DSM-5 (Diagnostic and Statistical Manual 5), das vor allem in den USA gebräuchlich ist, darzustellen. Darüber hinaus folgt eine kritische Betrachtung des Übertrages von ICD-10- auf -11-Diagnosen sowie Limitationen und Kritik an der Konzeption des ICD-11 und hinsichtlich der Verwendbarkeit in der Praxis.
Pharmakologische Rückfallprophylaxe der Alkoholabhängigkeit
Authors: Soyka Michael 
Published: August 2021

ZUSAMMENFASSUNGNur wenige Substanzen sind als sogenannte Anti-Craving-Me-dikamente zur pharmakogestützten Rückfallprophylaxe der Alkoholabhängigkeit zugelassen. Dazu gehören das in Deutschland nicht mehr vertriebene Disulfiram, die Opioidantagonisten Naltrexon und Nalmefen sowie Acamprosat. Gerade für Acamprosat und Naltrexon ist die Evidenzbasierung recht gut, bei mäßiger, aber klinisch signifikanter Effizienz. Sie werden trotzdem selten eingesetzt. Interessante Substanzen mit klinischer Perspektive sind am ehesten Baclofen, Vareniclin und Gabapentin. Die klinischen Befunde und Perspektiven der Pharmakotherapie bei Alkoholabhängigkeit werden dargestellt.
Multigram Synthesis of Difluoromethylene Phosphonic and Phosphinic Amides and Phosphine Oxides via Formal [2,3]-Sigmatropic Allyl Phosphite–Allylphosphonate Rearrangement
Authors: Shevchuk Michael , Röschenthaler Gerd-Volker 
Published: August 2021

AbstractWe describe a method for the preparation of CF2-P(V) building blocks and monomers for biological and materials chemistry applications in multigram quantities based on a formal [2,3]-sigmatropic phospha-Wittig rearrangement of readily available fluoroallyl bis(amido)phosphites, amido(aryl)phosphonites, and diarylphosphinites. The proposed intramolecular phosphorylation approach complements the currently prevailing phosphoryldifluoromethylation methods by providing a straightforward access to difluoromethylene phosphonate analogues bearing dialkylamino and/or aryl substituents at the phosphoryl group. An important advantage of the developed method is that it does not rely on ozone-depleting HCF2Cl and CF2Br2 necessary for the preparation of phosphoryldifluoromethylating reagents. 2,3,3-Trifluoroallyloxy P(III) derivatives substituted with two dialkylamino and/or aryl groups underwent a facile [2,3]-rearrangement to give difluoromethylene phosphonic and phosphinic amides and phosphine oxides on up to a 0.15 mol (30 g) scale. The reaction was extended to P(III) derivatives of 1-substituted 2,3,3-trifluoro- and 3,3-difluoroallylic alcohols readily available from carbonyl compounds and, respectively, 1,1,1,2-tetrafluoroethane and O-protected 2,2,2-trifluoroethanols. Products derived from O-(tetrahydropyran-2-yl)-2,2,2-trifluoroethanol were synthesized and deprotected in a one-pot multistep protocol to give phosphonic and phosphinic amide and phosphine oxide analogues of α,α-difluoro-β-ketophosphonates on a multigram scale.
Role for Graduate Medical Education in the Response to COVID-19 Pandemic in Southeast Michigan Community Health Care System
Authors: Sankari Abdulghani , Zakaria Ali , Taylor Glenn 
Published: August 2021

AbstractOn March 10, 2020, the State of Michigan reported its first case of severe acute respiratory syndrome due to coronavirus disease 2019, which was admitted to Ascension Providence Hospital (APH). Michigan was the third most affected state in March 2020. To address the pandemic, Department of Graduate Medical Education joined the incident command team which consisted of APH leaders (Accreditation Council for Graduate Medical Education Designated Institutional Official, the Chief Medical Officer as commander, Chief Operating Officer, Chief of Logistics, Chief Nursing Officer, representatives from the medical and surgical sections, laboratory, finance, infection control, and occupational health). The team initiated the “crisis capacity surge plan” that was focused on patient care and led mainly by our trainee. In this correspondence we share our successful experience and provide our recommendation on how GME can navigate pandemic crisis.
Cytotoxic Lesion in the Splenium of Corpus Callosum Secondary to Subacute Methotrexate Neurotoxicity
Authors: Al-Awwad Ahmad A. , Koriesh Ahmed 
Published: August 2021

AbstractMethotrexate neurotoxicity can present with a wide spectrum of neurologic symptoms and brain magnetic resonance imaging (MRI) typically demonstrates cerebral edema, demyelination, multifocal white matter necrosis, and atrophy relatively selective for the deep cerebral white matter. Here, we report a case of subacute methotrexate neurotoxicity in a 40-year-old man with B cell acute lymphoblastic leukemia. Brain MRI showed cytotoxic lesion in the splenium of corpus callosum and left middle cerebellar peduncle. Patient significantly improved 24 hours after receiving oral dextromethorphan. Methotrexate neurotoxicity should be suspected in any symptomatic patient receiving high dose of methotrexate or intrathecal methotrexate therapy. Dextromethorphan should be considered in these patients as it can modulate the excitatory responses to homocysteine and its metabolite which are usually elevated in such patients.
Perioperative Complications in Patients over 70 Years of Age following Simultaneous Bilateral Total Knee Arthroplasty
Authors: Kozai Landon , Matsumoto Maya , Mathews Kristin , Andrews Samantha , Nakasone Cass 
Published: August 2021

AbstractSingle-stage bilateral total knee arthroplasty (ssBTKA) can be used for patients presenting with bilateral arthritis and may result in fewer systemic and wound complications compared with two, independent procedures. However, the safety of ssBTKA in the elderly remains controversial. Therefore, the purpose of this study was to compare early complications and transfusion rates following ssBTKA in patients ≤ 70 years old or > 70 years old. This retrospective chart review of 313 consecutive patients undergoing ssBTKA included 174 patients ≤ 70 years old and 139 patients > 70 years old. Perioperative variables and postoperative complications were compared with univariate analyses between age groups. Multivariate analyses were performed to determine risk factors for developing perioperative complications and transfusions. Compared with patients ≤ 70, patients > 70 had significantly lower body mass index (p < 0.001) and were more commonly female (p = 0.024). Although wound (p > 0.12) and systemic complications (p > 0.54) were similar, 23% of patients > 70 required transfusion compared with only 8% of patients ≤ 70 (p < 0.001). Patients with preoperative anemia (p < 0.001), age > 70 (p = 0.002), or diabetes mellitus (p = 0.007) were at 5.7, 3.3, and 2.9 times greater risk for requiring a transfusion, respectively. Patients > 70 undergoing ssBTKA have a similar complication profile to patients ≤ 70 years old, suggesting age should not be an absolute exclusion criterion for ssBTKA. However, the risk of transfusion was significantly higher in those > 70, despite lower tourniquet times. Treatment of preoperative anemia may decrease the risk of transfusion and could provide adequate safety for patients > 70 to undergo ssBTKA by an experienced surgeon.
Deep-UV wavelength-selective photodetectors based on lateral transport in AlGaN/AlN quantum well and dot-in-well structures
Authors: Pramanik Pallabi , Sen Sayantani , Singha Chirantan , Bhattacharyya A. , Zhou Lin , Smith David J. 
Published: August 2021

We report on the development of deep-ultraviolet (DUV) wavelength-selective top-illuminated photodetectors based on AlGaN/AlN quantum-dots-in-wells. Structures consisting of 100 AlGaN wells and AlN barriers were grown by plasma-assisted molecular beam epitaxy on sapphire substrates. Interdigitated metal–semiconductor–metal photodetector devices were formed lithographically using indium as the contact metal. The effect of variation of the group III to group V flux ratio and the use of indium as a surfactant on the UV photoresponse were determined. Growth under near-stoichiometric conditions lead to a photocurrent peak in the 210–215 nm range with a peak width of ∼20 nm, with no other additional signatures in the entire UV–visible range. Under excess group III conditions, a second red-shifted peak was observed at ∼225 nm with significantly (up to 10×) higher responsivity. This enhancement was linked to the formation of quantum dots with truncated pyramidal structures with near-uniform size distribution and density of 6 × 1010 cm−2 within the quantum wells. Their formation was attributed to the process of droplet epitaxy. Such photodetectors do not require p-type doping or growth onto UV-transparent substrates and are appropriate for monitoring DUV skin-safe germicidal radiation in the presence of ambient visible light.
Assessing the state of the art in longitudinal L2 pronunciation research
Authors: Nagle Charles L. 
Published: August 2021

Abstract
Longitudinal research methods often call to mind studies of various lengths. However, longitudinal research
involves complex decisions related to study length, number of sessions, and session spacing, and these longitudinal choices must
be coordinated with other aspects of research methodology. In this synthesis, I analyze 39 longitudinal L2 pronunciation studies that were published between 2006 and 2021 and did not include a pronunciation-specific intervention. I examine longitudinal design choices in light of participant sample characteristics such
as age and context of learning, and measurement framework characteristics, which include choices related to target structures and
tasks. Among other findings, results point to a lack of longer-term, multiwave studies dealing with pronunciation development. I
offer suggestions for future work that can enhance the scope of L2 pronunciation research as well as recommendations for
conducting and reporting longitudinal research.