bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Multiplicity of a Proportionally Modular Numerical Semigroup
Authors: Gu Ze 
Published: September 2021

A proportionally modular numerical semigroup is the set

S

a
,
b
,
c

of nonnegative integer solutions to a Diophantine inequality of the form

a
x

mod

b
≤
c
x

, where

a
,
b

, and

c

are positive integers. A formula for the multiplicity of

S

a
,
b
,
c

, that is,

m

S

a
,
b
,
c

=

k
b

/
a

for some positive integer

k

, is given by A. Moscariello. In this paper, we give a new proof of the formula and determine a better bound for

k

. Furthermore, we obtain

k
=
1

for various cases and a formula for the number of the triples

a
,
b
,
c

such that

k
≠
1

when the number

a
−
c

is fixed.
Postoperative Effects of Dexmedetomidine on Serum Inflammatory Factors and Cognitive Malfunctioning in Patients with General Anesthesia
Authors: Zhang Zitan , Li Wei , Jia Huiqun 
Published: September 2021

Objective. To investigate the effects of dexmedetomidine intervention on serum inflammatory factor concentration and postoperative cognitive malfunction in elderly patients with general anesthesia. Methodology. 174 patients with general anesthesia were selected, who were categorized into a control group (HC) and a dexmedetomidine group (HS) using the random number table method, with 87 patients in individual groups. The dexmedetomidine group was pumped intravenously with dexmedetomidine at a loading dose of 1 μg/kg before induction of anesthesia for 15 min, followed by continuous intravenous pumping at a rate of 0.4 μg/kg/h, and the dosing was stopped at 30 min before concluding the surgery. The control group was administered the identical dose of saline in the same manner. Interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) levels and MMES scores were tested at 1 h before and 24 h after anesthesia. Results. Comparing to HC group, patients in the HS group had lower TNF-α and IL-6 levels at both scheduled points (

P

< 0.05). Conclusion. Dexmedetomidine reduced the expression of inflammatory factors in elderly patients with general anesthesia and effectively reduced the incidence of postoperative cognitive dysfunction after general anesthesia surgery.
Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice
Authors: Ahmad Feroz , Mitchell Robert D. , Houben Tom , Palo Angela , Yadati Tulasi , Parnell Andrew J. , Patel Ketan , Shiri‐Sverdlov Ronit , Leake David S. 
Published: September 2021

Background
We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases atherosclerosis in LDL receptor–deficient mice fed a high‐fat diet. We have now performed a regression study with cysteamine, which is of more relevance to the treatment of human disease.

Methods and Results
LDL receptor–deficient mice were fed a high‐fat diet to induce atherosclerotic lesions. They were then reared on chow diet and drinking water containing cysteamine or plain drinking water. Aortic atherosclerosis was assessed, and samples of liver and skeletal muscle were analyzed. There was no regression of atherosclerosis in the control mice, but cysteamine caused regression of between 32% and 56% compared with the control group, depending on the site of the lesions. Cysteamine substantially increased markers of lesion stability, decreased ceroid, and greatly decreased oxidized phospholipids in the lesions. The liver lipid levels and expression of cluster of differentiation 68, acetyl–coenzyme A acetyltransferase 2, cytochromes P450 (CYP)27, and proinflammatory cytokines and chemokines were decreased by cysteamine. Skeletal muscle function and oxidative fibers were increased by cysteamine. There were no changes in the plasma total cholesterol, LDL cholesterol, high‐density lipoprotein cholesterol, or triacylglycerol concentrations attributable to cysteamine.

Conclusions
Inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
The Epistemology of Biomimetics: The Role of Models and of Morphogenetic Principles
Authors: Krohs Ulrich 
Published: September 2021

Abstract
Form follows function, but it does not follow from function. Form is not derivable from the latter. To realize a desired technical function, a form must first be found that is able to realize it at all. Secondly, the question arises as to whether an envisaged form realizes the function in an appropriate way. Functions are multiply realizable—various different forms can bear the very same function. One needs to find a form of a technical artifact that realizes an envisaged function sufficiently efficient, robust, or whatever criteria might be imposed. This paper scrutinizes biomimetics as one way to find a good solution to the realization problem. Drawing on an approach from the philosophy of simulations, it reconstructs the biomimetic relation as being mediated by a theoretical model. It is shown that the robustness of the functioning system is usually reached in different ways in biological and in technological systems, which explains differences in morphogenetic mechanisms or principles found in these fields. This reconstruction helps to understand problems with robustness in synthetic biology that occur when technical design principles are implemented in a biological system. The mimetic relation between the biological and the technical realm is found to be asymmetric.
The Material Turn in the Study of Form: From Bio-Inspired Robots to Robotics-Inspired Morphology
Authors: Tamborini Marco 
Published: September 2021

Abstract
This paper investigates the mechanisms of knowledge production of twenty-first century robotics-inspired morphology. How robotics influences investigations into the structure, development, and change of organic forms? Which definition of form is presupposed by this new approach to the study of form? I answer these questions by investigating how robots are used to understand and generate new questions about the locomotion of extinct animals in the first case study and in high-performance fishes in the second case study. After having illustrated the landscape of twentieth-century morphology, I will reflect on the definition of form adopted in twenty-first century robotics-inspired morphology as well as on the differences between this approach to the study of form and the so-called nature-inspired disciplines, such as bionics or biomimetics. In the conclusion, I suggest that we are now in a material turn in morphology, characterized by the coexistence of the robotic, the virtual, and the real, which enables an understanding of how the structures and dynamics of shapes change over time.
ENSO Dynamics in the E3SM-1-0, CESM2, and GFDL-CM4 Climate Models
Authors: Chen Han-Ching , Jin Fei-Fei , Zhao Sen , Wittenberg Andrew T. , Xie Shaocheng 
Published: September 2021

AbstractThis study examines historical simulations of ENSO in the E3SM-1-0, CESM2, and GFDL-CM4 climate models, provided by three leading U.S. modeling centers as part of the Coupled Model Intercomparison Project phase 6 (CMIP6). These new models have made substantial progress in simulating ENSO’s key features, including: amplitude; timescale; spatial patterns; phase-locking; spring persistence barrier; and recharge oscillator dynamics. However, some important features of ENSO are still a challenge to simulate. In the central and eastern equatorial Pacific, the models’ weaker-than-observed subsurface zonal current anomalies and zonal temperature gradient anomalies serve to weaken the nonlinear zonal advection of subsurface temperatures, leading to insufficient warm/cold asymmetry of ENSO’s sea surface temperature anomalies (SSTA). In the western equatorial Pacific, the models’ excessive simulated zonal SST gradients amplify their zonal temperature advection, causing their SSTA to extend farther west than observed. The models underestimate both ENSO’s positive dynamic feedbacks (due to insufficient zonal wind stress responses to SSTA) and its thermodynamic damping (due to insufficient convective cloud shading of eastern Pacific SSTA during warm events); compensation between these biases leads to realistic linear growth rates for ENSO, but for somewhat unrealistic reasons. The models also exhibit stronger-than-observed feedbacks onto eastern equatorial Pacific SSTAs from thermocline depth anomalies, which accelerates the transitions between events and shortens the simulated ENSO period relative to observations. Implications for diagnosing and simulating ENSO in climate models are discussed.
Impact of Positive and Negative Socioemotional Behaviors on Remarital Instability
Authors: Kopystynska Olena , Bradford Kay , Higginbotham Brian , Whiteman Shawn D. 
Published: September 2021

We examined the trajectories of remarried couples’ ( N = 1161) positive and negative socioemotional behaviors, which reflect the expression of love versus hostility, in relation to remarital instability across the first 3 years of remarriage. The measures of behaviors included both self and partner reports. Guided by the Vulnerability-Stress-Adaptation model of marriage, we used multi-level modeling framework to test the proposed processes at between- and within-individual levels. Whereas self- and partner-reported positive behaviors predicted less remarital instability, self- and partner-reported negative behaviors predicted greater levels of remarital instability. Individual changes in self- and partner-reported positive behaviors related to less remarital instability and only changes in partner-reported negative behaviors were associated with increased remarital instability. Findings did not vary by gender or remarital profiles. The results provide support for the emergent distress model, suggesting that the path to remarital instability is rooted in gradually increasing negativity. Implications for practitioners are discussed.
Experience with pulmonary endarterectomy: Lessons learned across 17 years
Authors: Shetty Varun , Punnen Julius , Natarajan Pooja , Orathi Sanjay , Khan Basha , Shetty Deviprasad 
Published: September 2021

Background Pulmonary endarterectomy is potential curative therapy for chronic thromboembolic pulmonary hypertension patients. Here, we present our experience with pulmonary endarterectomy spanning 17 years and detail our management strategy. Methods This is a single-centre retrospective study conducted on chronic thromboembolic pulmonary hypertension patients who underwent pulmonary endarterectomy at our centre across 17 years. Results Between 2004 and 2020, 591 patients underwent pulmonary endarterectomy. Amongst them 429 (72.4%) were males with a male to female ratio of 2.6:1, the median age was 38 (range, 14–73) years. The median length of hospital stay was 11 days (IQR, 8–16). Extra corporeal membranous oxygenation was used in 82 (13.9%) patients during/after surgery, out of whom 28 (34.1%) survived. There were 70 (11.8%) in-hospital deaths. Female gender ( p < 0.01), pulmonary artery systolic pressure >100 mmHg ( p < 0.05) and use of extra corporeal membrane oxygenation ( p < 0.001) were significant risk factors for in-hospital mortality. The mortality in the first period (2004–2012) was 15.7% which reduced to 9.1% in the later period (2013–2020). The reduction in mortality rate was 42% ( p < 0.05). Following pulmonary endarterectomy, there was a significant reduction in pulmonary artery systolic pressure (86.68 ± 24.38 vs. 39.71 ± 13.13 mmHg; p < 0.001) and improvement in median walk distance as measured by 6-min walk test on follow-up (300 vs. 450 meters; p < 0.001). The median duration of follow-up was 8 months (inter-quartile range: 2–24). Conclusions pulmonary endarterectomy has a learning curve, high pulmonary vascular resistance alone is not a contraindication for surgery. Patients following surgery have improved survival and quality of life.
Unwelcome memento mori or best clinical practice? Community end of life anticipatory medication prescribing practice: A mixed methods observational study
Authors: Bowers Ben , Pollock Kristian , Barclay Stephen 
Published: September 2021

Background: Anticipatory medications are injectable drugs prescribed ahead of possible need for administration if distressing symptoms arise in the final days of life. Little is known about how they are prescribed in primary care. Aim: To investigate the frequency, timing and recorded circumstances of anticipatory medications prescribing for patients living at home and in residential care. Design: Retrospective mixed methods observational study using General Practitioner and community nursing clinical records. Setting/participants: 329 deceased adult patients registered with Eleven General Practitioner practices and two associated community nursing services in two English counties (30 most recent deaths per practice). Patients died from any cause except trauma, sudden death or suicide, between 4 March 2017 and 25 September 2019. Results: Anticipatory medications were prescribed for 167/329 (50.8%) of the deceased patients, between 0 and 1212 days before death (median 17 days). The likelihood of prescribing was significantly higher for patients with a recorded preferred place of death (odds ratio [OR] 34; 95% CI 15–77; p < 0.001) and specialist palliative care involvement (OR 7; 95% CI 3–19; p < 0.001). For 66.5% of patients (111/167) anticipatory medications were recorded as being prescribed as part of a single end-of-life planning intervention. Conclusion: The variability in the timing of prescriptions highlights the challenges in diagnosing the end-of-life phase and the potential risks of prescribing far in advance of possible need. Patient and family views and experiences of anticipatory medication care, and their preferences for involvement in prescribing decision-making, warrant urgent investigation.
Biomechanical Analysis of Segmental Medial Meniscal Transplantation in a Human Cadaveric Model
Authors: Haber Daniel B. , Douglass Brenton W. , Arner Justin W. , Miles Jon W. , Peebles Liam A. , Dornan Grant J. , Vidal Armando F. , Provencher CAPT Matthew T. 
Published: September 2021

Background: Meniscal deficiency has been reported to increase contact pressures in the affected tibiofemoral joint, possibly leading to degenerative changes. Current surgical options include meniscal allograft transplantation and insertion of segmental meniscal scaffolds. Little is known about segmental meniscal allograft transplantation. Purpose: To evaluate the effectiveness of segmental medial meniscal allograft transplantation in the setting of partial medial meniscectomy in restoring native knee loading characteristics. Study Design: Controlled laboratory study. Methods: Ten fresh-frozen human cadaveric knees underwent central midbody medial meniscectomy and subsequent segmental medial meniscal allograft transplantation. Knees were loaded in a dynamic tensile testing machine to 1000 N for 20 seconds at 0°, 30°, 60°, and 90° of flexion. Four conditions were tested: (1) intact medial meniscus, (2) deficient medial meniscus, (3) segmental medial meniscal transplant fixed with 7 meniscocapsular sutures, and (4) segmental medial meniscal transplant fixed with 7 meniscocapsular sutures and 1 suture fixed through 2 bone tunnels. Submeniscal medial and lateral pressure-mapping sensors assessed mean contact pressure, peak contact pressure, mean contact area, and pressure mapping. Two-factor random-intercepts linear mixed effects models compared pressure and contact area measurements among experimental conditions. Results: The meniscal-deficient state demonstrated a significantly higher mean contact pressure than all other testing conditions (mean difference, ≥0.35 MPa; P < .001 for all comparisons) and a significantly smaller total contact area as compared with all other testing conditions (mean difference, ≤140 mm2; P < .001 for all comparisons). There were no significant differences in mean contact pressure or total contact area among the intact, transplant, or transplant-with-tunnel groups or in any outcome measure across all comparisons in the lateral compartment. No significant differences existed in center of pressure and relative pressure distribution across testing conditions. Conclusion: Segmental medial meniscal allograft transplantation restored the medial compartment mean contact pressure and mean contact area to values measured in the intact medial compartment. Clinical Relevance: Segmental medial meniscal transplantation may provide an alternative to full meniscal transplantation by addressing only the deficient portion of the meniscus with transplanted tissue. Additional work is required to validate long-term fixation strength and biologic integration.
Effects of Pubertal Maturation on ACL Forces During a Landing Task in Females
Authors: Nasseri Azadeh , Lloyd David G. , Minahan Clare , Sayer Timothy A. , Paterson Kade , Vertullo Christopher J. , Bryant Adam L. , Saxby David J. 
Published: September 2021

Background: Rates of anterior cruciate ligament (ACL) rupture in young people have increased by >70% over the past two decades. Adolescent and young adult females are at higher risk of ACL injury as compared with their prepubertal counterparts. Purpose: To determine ACL loading during a standardized drop-land-lateral jump in females at different stages of pubertal maturation. Study Design: Controlled laboratory study. Methods: On the basis of the Tanner classification system, 19 pre-, 19 early-/mid-, and 24 late-/postpubertal females performed a standardized drop-land-lateral jump while 3-dimensional body motion, ground-reaction forces, and surface electromyography data were acquired. These data were used to model external biomechanics, lower limb muscle forces, and knee contact forces, which were subsequently used in a validated computational model to estimate ACL loading. Statistical parametric mapping analysis of variance was used to compare ACL force and its causal contributors among the 3 pubertal maturation groups during stance phase of the task. Results: When compared with pre- and early-/midpubertal females, late-/postpubertal females had significantly higher ACL force with mean differences of 471 and 356 N during the first 30% and 48% to 85% of stance, and 343 and 274 N during the first 24% and 59% to 81% of stance, respectively, which overlapped peaks in ACL force. At the point of peak ACL force, contributions from sagittal and transverse plane loading mechanisms to ACL force were higher in late-/postpubertal compared with pre- and early-/midpubertal groups (medium effect sizes from 0.44 to 0.77). No differences were found between pre- and early-/midpubertal groups in ACL force or its contributors. Conclusion: The highest ACL forces were observed in late-/postpubertal females, consistent with recently reported rises of ACL injury rates in females aged 15 to 19 years. It is important to quantify ACL force and its contributors during dynamic tasks to advance our understanding of the loading mechanism and thereby provide guidance to injury prevention. Clinical Relevance: Growth of ACL volume plateaus around 10 years of age, before pubertal maturation, meaning that a late-/postpubertal female could have an ACL of similar size to their less mature counterparts. However, late-/postpubertal females have higher body mass requiring higher muscle forces to accelerate the body during dynamic tasks, which may increase ACL loading. Thus, if greater forces develop in these females, in part because of their increased body mass, these higher forces will be applied to an ACL that is not proportionally larger. This may partially explain the higher rates of ACL injury in late-/postpubertal females.
Patient-Reported Outcome Scores and Rate of Return to Sport After Hip Arthroscopic Surgery: A Sex-Based Comparison in Professional and Collegiate Athletes
Authors: Glein Rachel M. , Jimenez Andrew E. , Miecznikowski Kara B. , Saks Benjamin R. , Ankem Hari K. , Sabetian Payam W. , Maldonado David R. , Lall Ajay C. , Domb Benjamin G. 
Published: September 2021

Background: No studies have compared outcomes and return to sport (RTS) after hip arthroscopic surgery between matched groups of male and female athletes with a minimum 2-year follow-up. Purpose: (1) To report minimum 2-year postoperative patient-reported outcome (PRO) scores and the RTS rate for elite female athletes undergoing hip arthroscopic surgery for femoroacetabular impingement (FAI) and (2) to compare clinical results with a matched control group of elite male athletes. Study Design: Cohort study; Level of evidence, 3. Methods: Data on all consecutive female athletes who underwent primary hip arthroscopic surgery performed at our institution between March 2009 and July 2018 were collected. Patients were eligible if they underwent hip arthroscopic surgery for labral tears or FAI and participated in collegiate or professional athletics within 1 year of surgery. Minimum 2-year postoperative PRO scores were collected for the modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), Hip Outcome Score–Sport-Specific Subscale (HOS-SSS), and visual analog scale (VAS) for pain as well as RTS status. The percentages of patients achieving the minimal clinically important difference (MCID) and patient acceptable symptomatic state were recorded. These patients were matched to elite male athletes for comparison. Results: A total of 73 female hips were included, with a mean follow-up of 65.1 ± 27.9 months. They demonstrated a significant improvement from preoperatively to latest follow-up on the mHHS, NAHS, HOS-SSS, and VAS ( P < .05). When outcomes were compared with a control group of male athletes, female athletes demonstrated lower preoperative scores, similar postoperative scores, and a significantly greater magnitude of improvement (delta value) on the mHHS, NAHS, and VAS. Female athletes also achieved the MCID at higher rates than did male athletes for the HOS-SSS (85.1% vs 70.0%, respectively; P = .035) and NAHS (79.1% vs 62.9%, respectively; P = .037). RTS rates among patients who attempted were similar between the 2 groups (female: 75.4%; male: 83.1%; P = .409). Conclusion: Elite female athletes undergoing primary hip arthroscopic surgery for FAI demonstrated a significant improvement in PRO scores and a high RTS rate. Female athletes exhibited a greater improvement in PRO scores (mHHS, NAHS, VAS) and achieved the MCID (HOS-SSS, NAHS) at higher rates compared with a control group of male athletes.
Sustainable Financing for Urban Karnataka: Viable Options
Authors: Vishal R.  , Sridhar Kala S. , Manasi S. 
Published: September 2021

The objectives of the current paper are to suggest measures to improve the taxation and tax collection mechanisms in selected cities of Karnataka. We review and reform (where necessary) bases of assessments of revenue streams and suggest enhancement of revenue sources by suitable mechanisms that can be implemented in all the selected cities. Finally, we estimate revenue capacities of the cities and recommend expansion capabilities. The methodology of the study involved visits to each of the selected 12 cities, examination of their audited financial statements, analysis of their major revenue sources and estimation of revenue capacities for each of the cities. We recommended measures to fix relevant policies to improve the system of tax collection and revenue generation mechanisms. Summarizing our findings, increasing revenue compliance from non-paying and unassessed properties and taxation of government properties of a commercial nature, increases the property tax base for all cities across the board. The next step is to increase values of properties, in accordance with market values in an economic sense, in a gradual manner. Water connections must be metered, given that water is a scarce resource, we find its revenue potential to be nearly the same as that from property tax.