bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mining netizen’s opinion on cryptocurrency: sentiment analysis of Twitter data
Authors: Hassan M. Kabir , Hudaefi Fahmi Ali , Caraka Rezzy Eko 
Published: November 2021

Purpose
This paper aims to explore netizen’s opinions on cryptocurrency under the lens of emotion theory and lexicon sentiments analysis via machine learning.

Design/methodology/approach
An automated Web-scrapping via RStudio is performed to collect the data of 15,000 tweets on cryptocurrency. Sentiment lexicon analysis is done via machine learning to evaluate the emotion score of the sample. The types of emotion tested are anger, anticipation, disgust, fear, joy, sadness, surprise, trust and the two primary sentiments, i.e. negative and positive.

Findings
The supervised machine learning discovers a total score of 53,077 sentiments from the sampled 15,000 tweets. This score is from the artificial intelligence evaluation of eight emotions, i.e. anger (2%), anticipation (18%), disgust (1%), fear (3%), joy (15%), sadness (3%), surprise (7%), trust (15%) and the two sentiments, i.e. negative (4%) and positive (33%). The result indicates that the sample primarily contains positive sentiments. This finding is theoretically significant to measure the emotion theory on the sampled tweets that can best explain the social implications of the cryptocurrency phenomenon.

Research limitations/implications
This work is limited to evaluate the sampled tweets’ sentiment scores to explain the social implication of cryptocurrency.

Practical implications
The finding is necessary to explain the recent phenomenon of cryptocurrency. The positive sentiment may describe the increase in investment in the decentralised finance market. Meanwhile, the anticipation emotion may illustrate the public’s reaction to the bubble prices of cryptocurrencies.

Social implications
Previous studies find that the social signals, e.g. word-of-mouth, netizens’ opinions, among others, affect the cryptocurrencies’ movement prices. This paper helps explain the social implications of such dynamic of pricing via sentiment analysis.

Originality/value
This study contributes to theoretically explain the implications of the cryptocurrency phenomenon under the emotion theory. Specifically, this study shows how supervised machine learning can measure the emotion theory from data tweets to explain the implications of cryptocurrencies.
Host‐modifying drugs against COVID‐19: some successes, but not yet the breakthrough
Authors: Brüssow Harald 
Published: November 2021

SummaryAfter reviewing antiviral drugs (Brüssow Environmental Microbiology 2021) the present review summarizes the results of clinical trials with host‐modifying drugs in COVID‐19 patients. Clinical benefits were observed with different immunomodulators. The variable outcomes of trials with the interleukin 6 receptor inhibitor tocilizumab demonstrated that treatment benefits might only be present in specific subgroups of patients or in specific infection stages. A meta‐analysis of trials with the interleukin 1 receptor antagonist anakinra showed a survival benefit only in patients with hyperinflammation. The Janus kinase inhibitor baricitinib is an anti‐inflammatory treatment that showed a clinical benefit in hospitalized patients who do not yet need supplementary oxygen. In contrast, the corticosteroid dexamethasone showed mortality reducing effects that were limited to patients on ventilation or in need of supplementary oxygen. Therapeutic dose of anticoagulation met the criteria for inferiority in severe cases, but showed a small survival benefit in non‐severe COVID‐19 patients. Large trials with colchicine showed a small or no survival benefit. Azithromycin, an antibiotic with immunomodulatory activity, showed no effects in numerous clinical trials. The trials showed a clear need for new drugs instead of repurposed drugs and drugs that specifically target the SARS‐CoV‐2 virus or the pathology developing in COVID‐19 patients.
Innovation Ecosystems: What Makes them Responsive during Emergencies?
Authors: Sahasranamam Sreevas , Soundararajan Vivek 
Published: November 2021

AbstractIn this paper, we examine what makes an innovation ecosystem responsive during emergencies. We studied the innovation ecosystem within Kerala (India) during emergencies that led to two emergency‐oriented innovations, namely KeralaRescue (developed for Kerala Floods 2018) and CoronaSafe (developed for COVID‐19), drawing on insights from strategic agility and institutional theory literature. We identified the enactment of three meta‐capabilities of agility by the innovation ecosystem, which made it responsive during the emergencies, namely, eco‐centric strategic sensitivity, eco‐centric resource fluidity and eco‐centric collective commitment. Further, we found that cognitive, structural and symbolic institutional arrangements facilitated the enactment of these eco‐centric strategic agility meta‐capabilities within the innovation ecosystem during the emergency. Our paper advances theory on innovation ecosystems and strategic agility, and generates implications for innovators and policymakers, developing solutions for COVID‐19 and other emergencies.
Differences in the gut microbiota composition of rats fed with soybean protein and their derived peptides
Authors: Li Wenhui , Li He , Zhang Yinxiao , Zhang Chi , Zhang Jian , Liu Xinqi 
Published: November 2021

AbstractCurrent studies regarding the effect of different nitrogen sources on gut microbiota have thus far disregarded the ability of probiotics and coliforms to compete for protein. This study aimed to investigate the differences in the utilization of soybean protein (SPro) and its derived peptides (SPep) by the gut microbiota of Sprague Dawley (SD) rats. The SPro and SPep prepared in this study showed extensive SPro molecular weight distribution, while that of SPep was minimal, ranging between 150 and 1000 Da and primarily consisting of two to five amino acids. The cecum microflora composition of the rats was determined via 16S rDNA amplicon sequencing, showing that the SPro and SPep significantly increased the abundance and uniformity of the gut microbiota after 35 days of feeding. The Firmicutes/Bacteroidetes (F/B) ratios of the SPep, SPro, and casein groups were 2.49 ± 0.60, 2.98 ± 1.12, and 2.59 ± 0.74, respectively. Although the rats fed with SPro and SPep displayed similar gut microbiome structures, SPep significantly promoted Lactobacillus and Phascolarctobacterium growth. The results showed that SPep significantly increased the diversity of the gut microbiota and elevated the probiotic proportion.Practical ApplicationSPro and SPep are two nutritious and high‐quality nitrogen sources. The results showed that SPro and SPep regulated the structure of gut microbiota in rats, and the effect of SPep was better. This study provides a theoretical basis for developing SPep functional foods able to regulate gut microbiota and maintain health.
The r package enerscape: A general energy landscape framework for terrestrial movement ecology
Authors: Berti Emilio , Davoli Marco , Buitenwerf Robert , Dyer Alexander , Hansen Oskar L. P. , Hirt Myriam , Svenning Jens‐Christian , Terlau Jördis F. , Brose Ulrich , Vollrath Fritz 
Published: November 2021

Abstract

Ecological processes and biodiversity patterns are strongly affected by how animals move through the landscape. However, it remains challenging to predict animal movement and space use. Here we present our new r package enerscape to quantify and predict animal movement in real landscapes based on energy expenditure.

enerscape integrates a general locomotory model for terrestrial animals with GIS tools in order to map energy costs of movement in a given environment, resulting in energy landscapes that reflect how energy expenditures may shape habitat use. enerscape only requires topographic data (elevation) and the body mass of the studied animal. To illustrate the potential of enerscape, we analyse the energy landscape for the Marsican bear (Ursus arctos marsicanus) in a protected area in central Italy in order to identify least‐cost paths and high‐connectivity areas with low energy costs of travel.

enerscape allowed us to identify travel routes for the bear that minimize energy costs of movement and regions that have high landscape connectivity based on movement efficiency, highlighting potential corridors. It also identifies areas where high energy costs may prevent movement and dispersal, potentially exacerbating human–wildlife conflicts in the park. A major strength of enerscape is that it requires only widely available topographic and body size data. As such, enerscape permits a first cost‐effective way to estimate landscape use and movement corridors even when telemetry data are not readily available, such as for the example with the bear.

enerscape is built in a modular way and other movement modes and ecosystem types can be implemented when appropriate locomotory models are available. In summary, enerscape is a new general tool that quantifies, using minimal and widely available data, the energy costs of moving through a landscape. This can clarify how and why animals move in real landscapes and inform practical conservation and restoration decisions.
Cladribine therapy for advanced and indolent systemic mastocytosis: Mayo Clinic experience in 42 consecutive cases
Authors: Tefferi Ayalew , Kittur Jaya , Farrukh Faiqa , Begna Kebede H. , Patnaik Mrinal M. , Al‐Kali Aref , Elliott Michelle A. , Reichard Kaaren K. , Gangat Naseema , Pardanani Animesh 
Published: November 2021

SummaryWe describe our single institution experience with cladribine therapy in 42 patients with systemic mastocytosis (SM): 22 advanced (adv‐SM; median age 65 years, 68% males) and 20 indolent/smouldering SM (ISM/SSM; median age 56 years, 45% males); subcategories included eight aggressive, 13 associated with another haematological neoplasm, one mast cell leukaemia, 17 ISM and three SSM. Overall/major response rates were 77%/45% for adv‐SM and 70%/60% for ISM/SSM, and median (range) duration of response 10 (4–75) and 46 (4–140) months respectively. A >50% reduction in bone marrow mast cell burden and serum tryptase level was documented in 63% and 67% of patients with adv‐SM and 50% and 46% with ISM/SSM respectively. The presence of KIT proto‐oncogene, receptor tyrosine kinase (KIT)D816V predicted response in adv‐SM: 17 (90%) of 19 with and none of three without the mutation responded (P < 0·01). Treatment‐emergent adverse events were mostly limited to transient cytopenias: Grade 3/4 neutropenia, thrombocytopenia, or lymphopenia occurred in 27%, 27% and 27% of patients with adv‐SM, and 5%, 5% and 30% with ISM/SSM respectively. The present study provides practical information that might be considered when making treatment choices between cladribine and newer KIT‐targeted therapies and identifies the absence of KITD816V as a potential marker of cladribine resistance in advanced SM; the latter observation needs confirmation in a larger study.
Types of parental psychological control and rural and urban Chinese adolescents’ psychological well‐being and academic functioning
Authors: Fang Qi , Liu Chunqiong , Tang Yanbo , Shi Zeyi , Wang Qian , Helwig Charles C. 
Published: November 2021

AbstractThe present study took a differentiated perspective on parental psychological control to examine its impact on adolescent adjustment among urban (n = 349, females: 53%) and rural (n = 293, females: 54%) Chinese adolescents (Mage = 12.14 years). Four times over the first 2 years of Junior High school (from October, 2016 to April, 2018), adolescents reported on parental psychological control, their psychological well‐being (life satisfaction and depressive symptoms), and academic relative autonomy. Adolescents’ grades also were obtained. The findings show generally negative effects of social comparison shame, love withdrawal and harsh psychological control (but not shared shame or parental relationship‐oriented guilt induction) on adolescents’ psychological well‐being, and negative effects of social comparison shame on adolescents’ academic functioning.
Principal–principal conflicts: An exploratory study in privatized companies in an Asian emerging economy
Authors: Eraković Ljiljana , Tran Trang Thi Thu , Stringer Christina 
Published: November 2021

AbstractResearch Question/IssueThis study examines the phenomenon of principal–principal conflicts in privatized companies in Vietnam. Since different types of shareholders may have competing interests, our study aims to address the following question: “How do different types of shareholders affect principal–principal conflicts in privatized companies in Asian emerging economies?”Research Findings/InsightsThrough a qualitative study, including 31 semistructured interviews with various governance actors from 14 privatized companies in Vietnam, we identify four types of principal–principal conflicts: (a) state controlling owners versus nonstate owners, (b) manager‐owners and affiliated strategic investors versus employee‐owners, (c) multiple opportunistic strategic investors versus minority employee‐owners, and (d) hibernating strategic investors versus other inside owners.Theoretical/Academic ImplicationsOur study contributes to the extant research on principal–principal conflicts in emerging economies. We advance the debate on the complexity of relationships between inside and outside shareholders. Our findings demonstrate that an understanding of controlling and minority shareholders and institutional conditions provides a more fine‐grained understanding of the complexity of principal–principal conflicts.Practitioner/Policy ImplicationsOur findings offer insights into how different types of shareholders seek to advance their own interests. This, in turn, can lead to them misinterpreting legal requirements. Thus, policymakers should consider different types of strategic investors and their strategic intent in the privatization process.
Excess liver transplant waitlist mortality for patients with primary biliary cholangitis under MELD‐Na allocation
Authors: Zhou Kali , Dodge Jennifer L. , Xu Edison , Emamaullee Juliet , Kahn Jeffrey A. 
Published: November 2021

AbstractBackgroundHistorically, patients with primary biliary cholangitis (PBC) experience waitlist mortality and low rates of liver transplant (LT). Herein, the impact of MELD‐Na based allocation on PBC waitlist mortality was examined.MethodsAdult patients with PBC were compared to those with alcohol‐related liver disease (ALD) or non‐alcoholic steatohepatitis (NASH) listed for LT from 2013 to 2019 in OPTN. Competing risk regression evaluated waitlist mortality in the MELD and MELD‐Na eras using propensity score weights.ResultsOverall, 1508 patients with PBC, 13581 with ALD, and 10455 with NASH were examined. In the MELD‐Na era, 24‐month cumulative incidence of waitlist mortality for PBC was 23.0% (95%CI 19.7–26.5%), ALD 13.9% (95%CI 13.1–14.8%), and NASH 20.0% (95%CI 18.9–21.2%). Using propensity score weights, adjusted risk of waitlist mortality was higher for PBC versus ALD (HR = 1.45, 95%CI 1.22–1.71) and NASH (HR = 1.32, 95%CI 1.14–1.55). Furthermore, among PBC, waitlist mortality risk per five‐point elevation in MELD‐Na (HR = 1.22, 95%CI 1.11–1.35) and Karnofsky score ≤30% (HR = 2.02, 95%CI 1.39–2.92) was significantly higher than among ALD (HR = 1.08, 95%CI 1.04–1.13; HR = 1.28, 95%CI 1.10–1.49) and NASH (HR = 1.05, 95%CI 1.00–1.09; HR = 1.16, 95%CI .99–1.37; all P‐interactions < .05).ConclusionsThe MELD‐Na score continues to underestimate risk of waitlist death for patients with PBC relative to ALD and NASH and highlights need for additional score modifications or exceptions.
Rituximab exposure‐response in triweekly R‐CHOP treatment in DLBCL: A loading dose is recommended to improve clinical outcomes
Authors: Liu Shu , Wang Zhao , Chen Rongxin , Huang He , Wang Xueding , Peng Chen , Guan Yanping , Fang Xiaojie , Guan Shaoxing , Huang Hongbing , Liu Tao , Lin Tongyu , Huang Min 
Published: November 2021

AbstractPrevious exposure‐response analyses for rituximab suggest that higher rituximab concentrations were associated with an improvement in efficacy, however, clinical studies investigating a higher rituximab dose had mixed results. To further explore the exposure‐response relationship of rituximab, a prospective observational analysis was performed involving 121 newly diagnosed patients with diffuse large B‐cell lymphoma treated with triweekly rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP). The trough concentration in the first cycle (C1‐trough) was significantly higher in patients achieving complete response (CR) compared with patients that did not achieve CR (22.00 μg/ml vs. 16.62 μg/ml, p = 0.0016), however, this difference between the two groups disappeared in later cycles. The relationship between rituximab C1‐trough and achieving a CR was confirmed by matched‐pair logistic regression analysis (odds ratio, 0.79; p = 0.0020). In addition, a higher C1‐trough (≥18.40 μg/ml) was associated with longer progression‐free survival (p < 0.0001) and overall survival (p = 0.0038). The percentages of patients that did not achieve a CR and had recurrence after CR within 24 months were 35% and 22.50%, respectively, for patients with a C1‐trough less than or equal to 18.40 μg/ml, compared with 12.35% and 6.17% for patients with C1‐trough greater than 18.40 μg/ml. Disease stage was found to be the most significant influencing factor of C1‐trough, with 51.02% of patients at stage IV with an observed C1‐trough less than 18.40 μg/ml. For these advanced patients, population pharmacokinetic simulations using an established model suggest that a loading dose of 800 mg/m2 may help to improve clinical outcomes.
Overabundant native herbivore impacts on native plant communities in south‐eastern Australia
Authors: Morgan John W. 
Published: November 2021

SummaryNative herbivores can affect the structure and function of plant communities. Most studies of overabundant native herbivore effects on native plant communities in south‐eastern Australia are observational or compare, at most, two levels of herbivory (ambient vs. none), and typically do not separate out the impacts of multiple herbivores. Several studies show that high densities of herbivores had mostly negative effects on plant regeneration and growth. These effects were usually attributed to palatability differences amongst plant species. Surprisingly, few studies have quantified vegetation responses across a gradient of herbivore density, and impacts on plant communities (i.e. species richness, composition, beta diversity) have not been well studied. Hence, there remains a need to better understand how native herbivores impact plant communities at different densities.
Seasonal breeding of the Eastern Grey Kangaroo provides opportunities for improved animal welfare in kangaroo management
Authors: Lucas Zohara , Pulsford Stephanie , Wimpenny Claire , Snape Melissa 
Published: November 2021

SummaryThe challenge of maintaining biodiversity by managing overabundant native fauna is often a contentious issue. This study demonstrates a means of improving animal welfare in the culling of overabundant kangaroos. We studied five populations of Eastern Grey Kangaroo (Macropus giganteus) in the Australian Capital Territory and established the percentage of juveniles throughout the year. We focused on juveniles aged 8–12 months old, as these are identified at greatest risk of poor welfare outcomes if orphaned. Our findings support the timing of culls when the fewest vulnerable juveniles are present in the population. This paper provides a scientific basis for land managers to adjust the timing of kangaroo management activities to best balance animal welfare, land management and conservation objectives.
Rapid population expansion of Boodie (Burrowing Bettong, Bettongia lesueur) creates potential for resource competition with Mala (Rufous Hare‐wallaby, Lagorchestes hirsutus)
Authors: Treloar Shannon , Lohr Cheryl , Hopkins Anna J. M. , Davis Robert A. 
Published: November 2021

SummaryTranslocations to closed systems such as fenced reserves are commonly used for conservation of threatened fauna species worldwide; however, resources are limited in these areas, and natural processes that regulate populations in response to resource availability are unable to occur. This can result in overabundance followed by overuse of resources, potentially resulting in extreme declines or local extinctions. Resource exhaustion can negatively impact other fauna in the closed environment that exploit similar resources, through inter‐specific competition. This paper discusses the reintroduction of Boodie (Bettongia lesueur) and Mala (Lagorchestes hirsutus) to a fenced reserve on the Matuwa Indigenous Protected Area, Western Australia, and raises the concern of potential competition between the two threatened species.
Species composition, herbage mass and grass productivity influence pasture responses to kangaroo grazing in a temperate environment
Authors: Snape Melissa A. , Fletcher Don , Caley Peter 
Published: November 2021

SummaryUnderstanding the complexities of pasture responses (the overall seasonal gains or losses in herbage mass) under different environmental conditions is critical to the effective management of total grazing pressure, whether to achieve agricultural, cultural or biodiversity conservation outcomes. Whilst large‐scale management programmes for kangaroos (Macropus spp. and Osphranter spp.) occur across much of south‐eastern Australia, there is limited understanding of how such programmes influence the overall pasture response across different environmental contexts in the temperate environment. This study investigates the effects of potential grass productivity (measured as the growth of pasture protected from large herbivore grazing), initial herbage mass (measured as the attached, above‐ground component of grass tussocks), kangaroo density (measured at the site scale) and season on the overall pasture response in plots dominated by six common grass types from south‐eastern Australia. Using generalised additive mixed modelling, we demonstrate potential grass productivity (related to but not synonymous with grass palatability) to be the major predictor variable for pasture responses across all six grass types. Kangaroo density, either directly or via an interaction with initial herbage mass, was related to overall pasture responses for most grasses in spring and remained an important variable in favoured areas dominated by preferred Kangaroo Grass (Themeda triandra) and Redleg Grass (Bothriochloa macra) throughout the autumn survey period. Plots dominated by grazing‐tolerant species, including wallaby grasses (Rytidosperma spp.) and Phalaris (Phalaris aquatica; an introduced pasture grass), showed marginally positive pasture responses under higher kangaroo densities, whilst plots with Wild Oats (Avena fatua; an introduced annual grass) and less preferred native spear grasses (Austrostipa spp.) showed no significant effect of kangaroo density on pasture response. Results support a context‐specific mix of ‘bottom‐up’ (resource‐driven) and ‘top‐down’ (consumer‐driven) processes in temperate grassy ecosystems, highlighting the importance of considering landscape productivity, existing herbage mass and grass species composition when informing kangaroo management decisions.