bluuebunny/crossref_metadata_2025_split huggingface dataset:
The workability of the castables bonded with hydrated magnesium carboxylate–organic acid
Authors: Chen Jianjun , Xiao Guoqing , Ding Donghai , Wang Qingfeng , Liu Ming , Yin Chaofan , Yang Junrui , Li Xue , Luo Wei , Tang Wenwen , Li Tengfei 
Published: December 2024

AbstractThis study modifies the hydration process of hydrated magnesium carboxylate (HMC) by organic acids to improve the workability of HMC‐bonded castables (HMCC), while comprehensively analyzing the effects of organic acids on the mechanical properties and thermal shock resistance of HMCC. Results demonstrate that lactic acid significantly increases the setting time and rheology of HMCC by 738% and 217.8%, respectively. This is due to lactic acid inhibiting HMC ionization and delaying hydration, as evidenced by hydration kinetics experiments. Furthermore, lactic acid could also reduce the degree of polymerization of HMC hydration products. Notably, lactic acid increases the cold modulus of rupture by 593.7%, 100%, and 95.7% at 500°C, 800°C, and 1100°C, respectively. This performance improvement is attributed to lactic acid's promotion of the sintering process of HMCC, possibly due to its effect on improving castable uniformity. However, lactic acid results in an 18.1% reduction in the green body strength, potentially due to the weakened three‐dimensional network structure of HMC hydration products. Additionally, lactic acid increases the residual strength ratio of HMCC by 4.3% and enhances crack propagation resistance (R‴) by 45%. These improvements result from an optimized microstructure, characterized by smaller, more uniformly distributed particles with regular shapes and tighter interparticle connections.
Exploring the Direct and Indirect Relations of E‐Book Narration and Bilingual Parent–Child Talk to Children's Learning Outcomes in EFL Shared Reading
Authors: Yang Dandan , Zeng Huaming , Collins Penelope , Warschauer Mark 
Published: December 2024

ABSTRACTE‐books, powered by multimedia and interactive features, are widely used to support young children's language and literacy development. This study examines the relations of e‐book narration and bilingual parent–child talk to children's learning during shared reading. Data from 121 English learners in China and their parents were analyzed using structural equation modeling. Results revealed that e‐book narration, powered by multimedia features, indirectly predicts children's learning outcomes through parent and child talk in English. Specifically, parent talk in English fully mediated the relationship between e‐book narration and children's English vocabulary gains, while parent and child talk in English mediated the association between e‐book narration and story comprehension and retelling. In contrast, parent–child talk in Chinese did not predict any learning outcomes. Video transcript analysis showed that off‐topic talk was more prevalent in Chinese than in English, particularly among children. These findings have implications for app designers, parents, and researchers, emphasizing the importance of parental support in shared e‐book reading and shedding light on the e‐book design for children reading in a foreign language.
Consortium Governance and Market Entry of Digital B2B Platforms: The Case of ADAMOS
Authors: Arnold Laurin , Hukal Philipp , Link Marco 
Published: December 2024

ABSTRACTIn this study, we examine how the Industrial Internet of Things platform ADAMOS successfully entered the German mechanical engineering market using a consortium‐based approach. By establishing a joint venture among industry incumbents, ADAMOS followed consortium governance that separated platform ownership from platform operation. In so doing, ADAMOS navigated the complexities of market entry and overcame many challenges typical to business‐to‐business (B2B) markets. Drawing from the case, we develop a four‐step framework for effective business‐to‐business platform market entry: (1) Spinning out a neutral legal entity, (2) designing a valuable platform core, (3) seeding the supply side with internal offerings, and (4) opening the platform to broader audiences. Based on this description, we discuss lessons learned and provide actionable recommendations for platform operators considering a consortium‐based approach for their business‐to‐business platform market entry.
A Neutrophil Extracellular Traps–Related Signature Predicts Clinical Outcomes and Identifies Immune Landscape in Ovarian Cancer
Authors: Zhang Yue , Wang Chao , Cheng Shanshan , Xu Yanna , Gu Sijia , Zhao Yaqian , Yang Jiani , Wang Yu 
Published: December 2024

ABSTRACTOvarian cancer (OvCa) is the most lethal gynaecology malignancies worldwide. Neutrophil extracellular traps (NETs), net‐like protein structures produced by activated neutrophils and DNA‐histone complexes, have a central role in tumours, though haven't been fully explored in OvCa. We obtained transcriptome data from TCGA‐OvCa database (n = 376) as training, ICGC‐OvCa database (n = 111) as validation and GTEx database (n = 180) as controls. Through LASSO‐COX Regression analysis, we identified an eight‐gene signature among 87 NETs‐related genes, which was significantly related to poor prognosis in both TCGA‐OvCa and ICGC‐OvCa cohorts (Log‐rank p‐value = 0.0003 and 0.0014). Next, we constructed and validated a prognostic nomogram, consist of NETs‐related signature and clinical features (C‐index = 0.82). We evaluated 22 typical immune cell infiltration through CIBERSORT analysis, which implied upregulation of memory CD4 + T cells, follicular helper T cells and neutrophils in high‐risk group. Additionally, we predicted therapy sensitivity through TIDE algorithm, indicating that high NETs‐riskscore exhibited more sensitivity towards Sorafenib and less sensitivity towards immunotherapy. We initially reported that RAC2 upregulation was associated with NETs formation and poor prognosis (p‐value < 0.05) through IHC analysis of tissue microarrays (n = 125). Conclusively, NETs‐related signature was reliable for OvCa prognosis prediction and therapy assessment. Especially, RAC2 was predominantly related to NETs formation, thus providing hints towards anti‐tumour mechanism of NETs in OvCa.
Puerarin Protects Myocardium From Ischaemia/Reperfusion Injury by Inhibiting Ferroptosis Through Downregulation of VDAC1
Authors: Hu Fajia , Hu Tie , He Andi , Yuan Yong , Wang Xiuqi , Zou Chenchao , Qiao Yamei , Xu Huaihan , Liu Lanxiang , Wang Qun , Liu Jichun , Lai Songqing , Huang Huang 
Published: December 2024

ABSTRACTDespite improvements in interventional techniques leading to faster myocardial reperfusion postmyocardial infarction, there has been a significant rise in the occurrence of myocardial ischaemia/reperfusion injury (MI/RI). A deeper understanding of the underlying mechanisms of MI/RI could offer a crucial approach to reducing myocardial damage and enhancing patient outcomes. This study examined the myocardial protective properties of puerarin (PUE) in the context of MI/RI using hypoxia/reoxygenation (H/R) or ischaemia/reperfusion (I/R) injury models were employed in H9c2 cells and C57BL/6 mice. Our findings demonstrate that pretreatment with PUE effectively mitigated cardiomyocyte ferroptosis, restored redox balance, preserved mitochondrial energy production and maintained mitochondrial function following MI/RI. Furthermore, these cardioprotective effects of PUE were found to be mediated by the downregulation of voltage‐dependent anion channel 1 (VDAC1) protein. These data reveal a novel mechanism by which PUE inhibits MI/RI and reveal that this protective effect of PUE is dependent on the downregulation of VDAC1.
Assessing biodiversity‐related disclosure: Drivers, outcomes, and financial impacts
Authors: Bassen Alexander , Buchholz Daniel , Lopatta Kerstin , Rudolf Anna R. 
Published: December 2024

AbstractBiological diversity—the complex tapestry of life and ecosystems—is facing an urgent global crisis, with increasing extinction rates and the loss of variety on all levels of biodiversity from genetic to ecosystem diversity. This study analyzes 2843 environmental, social, and governance (ESG) reports by companies from 43 countries, focusing on Global Reporting Initiative (GRI) standards, and examines the quality of biodiversity‐related disclosure (BRD) from 2010 to 2019. The study achieves three objectives. First, it provides a global assessment of the quality of BRD, which declines after 2015 despite increased recognition of the importance of biodiversity. Second, it identifies the influence of climate‐related risks and management incentives as internal determinants of BRD quality. Third, in examining the consequences of BRD, it highlights the impact of BRD quality on investor risk perception and stakeholder perceptions (i.e., corporate reputation). Improved BRD quality increases perceived risk. For companies with biodiversity impacts, however, the effect is the opposite, suggesting that investors do not fully understand the risks of biodiversity dependency. These findings suggest the need for equal recognition of biodiversity alongside climate change in reporting standards and policies.
Nurses' Workplace Violence Reporting Behaviours and Reasons for Not Formally Reporting: A Cross‐Sectional Secondary Analysis
Authors: Lee Jenny , Havaei Farinaz , Hirani Saima , Adhami Nassim 
Published: December 2024

ABSTRACTAimTo investigate predictors of nurses' reporting behaviours and their reasons for not formally reporting.BackgroundUnderreporting of workplace violence (WPV) among nurses contributes to gaps in WPV prevention measures, as it cannot be fully understood. WPV is classified according to its source (Type II: patients and visitors, Type III: coworkers) and forms (physical assault, threat of assault, emotional abuse, verbal sexual harassment and sexual assault).DesignThis is a secondary analysis of cross‐sectional survey data collected in 2019 from British Columbia (BC), Canada.MethodsThis study had a sample of 4109 BC nurses. Multinomial logistic regression was used to analyse predictors of reporting behaviours. Reasons for not reporting were analysed descriptively.ResultsInformal reporting to management or through a patient safety incident report was less likely when nurses experienced threat of assault, emotional abuse and verbal sexual harassment from both Type II and III sources and physical assault from Type III sources. Higher perceptions of WPV prevention efforts increased odds of informal and formal reporting through employee incident procedures. Believing that nothing would change after reporting remained among the top three reasons for not formally reporting across all WPV sources and forms. Nurses also commonly selected not knowing the formal process, lack of leadership support and other reasons stated in an open‐text response.ConclusionFindings indicate that nurses in BC, Canada, perceive many barriers to formal WPV reporting. Formal reporting systems should address these barriers so that healthcare organisations can effectively track WPV and have data to inform WPV prevention measures.ImplicationsTo promote WPV reporting, healthcare organisations need multifaceted interventions including confidential and simplified reporting systems, leadership support to follow‐up with nurses and education and training on reporting systems.Reporting MethodThe authors of this manuscript have adhered to the relevant EQUATOR guidelines based on the STROBE cross‐sectional reporting method.Patient or Public ContributionNo patient or public contribution.
Simplicity and Risk
Authors: PURI INDIRA 
Published: December 2024

ABSTRACTI introduce and test for preference for simplicity in choice under risk. I characterize the theory axiomatically, and derive its properties and unique predictions relative to canonical models. By designing and running theoretically motivated experiments, I document that people value simplicity in ways not fully captured by existing models that study risk premia in financial markets. Participants' risk premia increase as complexity increases, holding moments fixed; their dominance violations increase in complexity; their behavior is predicted by simplicity's characterizing axiom; and their complexity aversion is heterogeneous in cognitive ability. None of expected utility theory, cumulative prospect theory, prospect theory, rational inattention, sparsity, salience, or probability weighting that differs by number of outcomes fully capture the experimental findings. I generalize the underlying theory to additionally capture broader measures of complexity, including obfuscation, computation, and language effects.
Living with acuteness in chronic illness: The temporal underpinnings of endometriosis
Authors: Oikkonen Venla , Helosvuori Elina 
Published: December 2024

AbstractThis article explores how acuteness is experienced by people with endometriosis in Finland. Drawing on in‐depth interviews as well as anonymous written endometriosis stories, we trace instances when the sense of chronicity and cyclicality of endometriosis is disrupted by a possibility of risk to life. These instances include when endometriosis tissue grows in unanticipated and aggressive ways, when medical interventions lead to unexpected complications or medications raise concerns about a gradually developing risk, and when endometriosis diagnosis becomes a catch‐all category that could mask the onset of a life‐threatening condition. Our analysis of illness experiences suggests that, while risk to life is an unlikely outcome in chronic conditions such as endometriosis, concerns about risk shape how the chronicity and cyclicality of endometriosis are felt and managed in everyday life.
Regulation of nucleus‐encoded trans‐acting factors allows orthogonal fine‐tuning of multiple transgenes in the chloroplast of Chlamydomonas reinhardtii
Authors: Mordaka Pawel Mateusz , Clouston Kitty , Gorchs‐Rovira Aleix , Sutherland Catherine , Zhang Daniel Qingyang , Geisler Katrin , Mehrshahi Payam , Smith Alison Gail 
Published: December 2024

SummaryThe green microalga Chlamydomonas reinhardtii is a promising host organism for the production of valuable compounds. Engineering the Chlamydomonas chloroplast genome offers several advantages over the nuclear genome, including targeted gene insertion, lack of silencing mechanisms, potentially higher protein production due to multiple genome copies and natural substrate abundance for metabolic engineering. Tuneable expression systems can be used to minimize competition between heterologous production and host cell viability. However, complex gene regulation and a lack of tight regulatory elements make this a challenge in the Chlamydomonas chloroplast. In this work, we develop two synthetic tuneable systems to control the expression of genes on the chloroplast genome, taking advantage of the properties of the vitamin B12‐responsive METE promoter and a modified thiamine (vitamin B1) riboswitch, along with nucleus‐encoded chloroplast‐targeted regulatory proteins NAC2 and MRL1. We demonstrate the capacity of these systems for robust, fine‐tuned control of several chloroplast transgenes, by addition of nanomolar levels of vitamins. The two systems have been combined in a single strain engineered to avoid effects on photosynthesis and are orthogonal to each other. They were then used to manipulate the production of an industrially relevant diterpenoid, casbene, by introducing and tuning expression of the coding sequence for casbene synthase, as well as regulating the metabolite flux towards casbene precursors, highlighting the utility of these systems for informing metabolic engineering approaches.
Plant Volatile Methyl Salicylate Primes Wheat Defense Against the Grain Aphid by Altering the Synthesis of Defense Metabolites
Authors: Li Zhenxiang , Jing Shizhao , Wang Da , Song Zichao , An Boyang , Wang Saige , Liu Fanghua , Di Ning , Aradottir Gudbjorg Inga , Sun Jianghua , Tan Xiaoling , Qu Cheng , Kang Zhiwei 
Published: December 2024

ABSTRACTWheat (Triticum aestivum L.) is one of the most important staple crops all over the world. Its productivity is adversely affected by aphid infestation. Plant volatiles play a critical role in plant communication, inducing direct and indirect defenses against insect pests. However, little is known about the priming mechanism of key volatiles in wheat. To determine whether and how plant volatile induced defense priming in wheat against the grain aphid Sitobion avenae, a combination of insect bioassays, phytohormone and defense metabolite quantification, and transcriptome analyses were performed using an important aphid damage‐induced plant volatile, methyl salicylate (MeSA). MeSA treatment primed wheat for enhanced accumulation of salicylic acid, flavonoid and benzoxazinoids (BXs), and increased resistance to S. avenae and attractiveness to an aphid parasitoid Aphelinus asychis. Supplementation with a BX (2,4‐dihydroxy‐7‐methoxy‐2H‐1,4‐benzoxazin‐3(4H)‐one) and two flavonoids (xanthohumol and isobavachalcone) in artificial diet impaired the survival, development and fecundity of S. avenae. Moreover, MeSA treatment induced wheat volatile emission especially MeSA. Functional investigation of odorant‐binding proteins (OBPs) in A. asychis revealed that AasyOBP4 is responsible for the recognition of MeSA. Taken together, our results provide insights into the molecular mechanism of MeSA‐mediated defense in wheat and propose MeSA as a phytoprotectant for crop protection and sustainable agriculture.
Videodermoscopy as a Diagnostic Tool for Pili Trianguli and Canaliculi Syndrome
Authors: Sechi Andrea , Bolzon Anna , Tartaglia Jacopo , Tosti Antonella , Mariano Luca 
Published: December 2024

ABSTRACTPili trianguli et canaliculi syndrome is a rare hair shaft disorder characterized by frizzy hair that cannot be smoothed flat. Affected hair shafts are triangular or kidney‐shaped with longitudinal grooving. Diagnosis typically requires electron microscopy, which may be cost‐prohibitive, or alternatively, the distinctive features of hair shafts can be identified through histological examination of cross sections, that is time‐consuming. To overcome these challenges, we describe a novel videodermoscopy technique as a cost‐effective and simple alternative, suitable for outpatient settings.
Beyond Classification: A Unique Case of Self‐Resolving Cutaneous Mucinosis Associated With Streptococcal Infection in a Child
Authors: Safir Ari , Furman Moran , Gat Andrea , Zemser Valentina , Bergman Reuven , Sprecher Eli , Samuelov Liat , Friedel Nadav 
Published: December 2024

ABSTRACTA 3‐year‐old boy presented with an unusual combination of indurated skin, sclerotic plaques with lichenification, and yellowish papules. Histopathology revealed diffuse dermal mucin deposits, and laboratory tests showed a positive throat culture for Group A streptococcus and elevated serum anti‐streptolysin titers. An 10‐day course of oral amoxicillin was associated with near‐complete resolution of all dermatological findings within 4 months. This case represents a unique presentation of a self‐resolving cutaneous mucinosis, likely associated with a streptococcal infection.
Photodynamic therapy of cancer‐associated infections
Authors: Kassab Giulia , Chen Juan , Zheng Gang 
Published: December 2024

AbstractPathogens can be involved in tumor initiation, promotion, and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections and, therefore, has a unique potential to address their combination. However, we believe this potential has been underutilized, and few researchers have investigated the impacts of PDT of both infection‐related and cancer‐related outcomes at once. This review presents the main agents behind cancer‐associated infections (CAIs), the PDT protocols that have been tested on them, and their key findings. Additionally, we discuss the key aspects of PDT that make it ideal for CAI treatment, and what knowledge gaps need to be filled in order to make it successful.
Expanding Perceived Capacity of Public Sector Workers: Experimental Evidence on the Impact of a Counter‐Stereotypical Narrative on Public Perceptions of Correctional Officers
Authors: Harney Jessie 
Published: December 2024

ABSTRACTUnderstanding variation in perceptions of different types of street‐level bureaucrats (SLBs) is crucial, as is improving perceptions of the capacity of government to better serve its community in an ethical and authentic manner. In this U.S.‐based survey experiment (n = 1642), participants who were randomly assigned to be initially presented with a counter‐stereotypical narrative of a correctional officer (CO) – a limitedly studied SLB – perceived COs as significantly more dedicated, compassionate and skilled than those who were presented this narrative after survey outcomes, with no impacts on perceptions of other public sector workers. Additionally, there was strong support for the claim that people, with access to the right type of training and education, can do most types of work. Collectively, this study may help guide future research to understand the viability of myriad changes to the way the United States handles justice, especially in relation to alternative models that rely on greater presence of public sector health and wellness practitioners.
The Utility of Interferon‐γ Release Assays in the Diagnosis of Tuberculosis in Patients With Cancer
Authors: Batista Marjorie V. , Sassine Joseph , Khawaja Fareed , Kulkarni Prathit A. , Angelidakis Georgios , Kmeid Joumana , El Chaer Firas , Ariza‐Heredia Ella J. , Graviss Edward A. , Mulanovich Victor E. , Chemaly Roy F. 
Published: December 2024

ABSTRACTBackgroundPatients with cancer are at elevated risk for tuberculosis (TB) reactivation. Diagnosis of latent TB infection and TB disease remains challenging in this patient population despite the advent of interferon‐γ release assays (IGRA).MethodsWe retrospectively reviewed medical records of all patients with cancer who had IGRA testing (QuantiFERON–TB [QFT‐TB] or T‐SPOT.TB) at a major cancer center in the United States from June 2010 to July 2017. The results were analyzed with respect to the likelihood of latent TB infection and TB disease.ResultsA total of 1299 patients were included with 1599 tests performed: 586 QFT‐TB and 1013 T‐SPOT.TB. Forty‐nine (4%) patients were diagnosed with latent TB, and four (1%) with TB disease. T‐SPOT.TB was more likely to yield an actionable result (positive or negative) than QFT‐TB (89% vs. 65%, p < 0.001). The rate of indeterminate results for QFT‐TB was higher than the rate of invalid results for T‐SPOT.TB (35% and 10%, respectively, p < 0.001). On multivariate analysis, independent predictors of an invalid T‐SPOT.TB included prior receipt of alemtuzumab, lower hemoglobin, absolute lymphocyte count, or serum albumin (p < 0.05 each), whereas the independent predictors of an indeterminate QFT‐TB were female gender, prior receipt of systemic corticosteroids, and lower hemoglobin, or serum albumin or higher absolute neutrophil count (p < 0.05 each).ConclusionsT‐SPOT.TB yielded more actionable results than QFT‐TB in patients with cancer. T‐SPOT.TB might be a better IGRA for screening for latent TB infection in patients with cancer, although a direct comparison would be needed to definitively determine this.
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