bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Flow Nasal Cannula and Prone Positioning in Awake Patients with COVID-19 Related Respiratory Failure: An Observational Study.
Authors: Abroug Fekri , Hammouda Zeineb , Lahmar Manel , Nouira Wiem , Maatouk Syrine , Youssef Sourour Belhaj , Dachraoui Fahmi , Ouanes-Besbes Lamia 
Published: November 2021

Abstract
Background: We report an observational study on the use of High-flow nasal cannula (HFNC) and awake prone position in patients with Covid-19 related severe ARF.Methods: chart analysis of consecutive patients with confirmed Covid-19 and severe ARF (PaO2/FiO2 ratio <150) who received HFNC. Patients were systematically encouraged to lie in the prone position if tolerated. We calculated initial ROX index (the ratio of SpO2/FIO2 to respiratory rate) while in supine position and at the end of the first HFNC session whether in prone or supine position, and their difference (delta ROX). The success/failure of HFNC (need for intubation) was recorded. Predictors of HFNC failure were identified using ROC curve and logistic regression.Results: HFNC was administered to 213 out of 360 patients with COVID-19 related severe ARF (71% male, median age:59 years (IQR:50-68), median PaO2/FIO2: 104(73-143). At the start of HFNC, median ROX index was 4(3.4-5). Among included patients, 178 (83.5%) could tolerate prone position and had a median of 4.4(2-6) prone sessions during a median of 10(4-16) hours/day each, for a median of 4(2-7) days. Overall, HFNC failure occurred in 61 patients (28.1%) with similar proportions in patients who had HFNC in prone position and in patients who did not tolerate prone position (29% and 26%, respectively; relative risk:1.14. 95%CI:0.62-2.1). In the prediction of HFNC outcome, AUC was highest for delta ROX (AUC=0.83); AUC for baseline ROX (0.71), PaO2/FiO2 (0.73), and SpO2 (0.67), were significantly lower. The delta ROX cut-off ≤1.8 had the best Youden index indicating the best combination of sensitivity (0.89) and specificity (0.61) with a PLR (2.33) and a NLR (0.17) to predict HFNC failure. Logistic regression disclosed the following predictors of HFNC failure: delta ROX: RR=0.44, 95%CI=0.32-0.62; p-0.0001); baseline ROX index: RR=0.58, 95% CI:0.39-0.85, p=0.005); SOFA score (RR=1.6 for each point; 95%CI: 1.1-2.2, p=0.007); and PaO2/FiO2 at admission: RR=0.96, 95%CI=0.94-0.99). Prone position was not related to HFNC success.CONCLUSION: Awake HFNC in prone position is feasible in most patients with severe hypoxemic COVID-19. Indicators of ARF severity and the early response to HFNC, rather than prone position are independently associated with HFNC outcome.
Analyzing and prediction of rainfall trends over Baghdad city
Authors: Khtan Asraa , Al-ATABI Iqbal Khalaf 
Published: November 2021

Abstract
Rainfall is a key part of the hydrological cycle and alteration of its pattern directly affects the water resources. The changing pattern of rainfall in consequence of climate change is now concerning issues to water resource managers and hydrologists. The present study aims to analyze the trend and forecast annual rainfall in Baghdad. rainfall data for the period of 1979-2019 was analyzed in this study, Statistical trend analysis techniques namely linear and Exponential trend were used to examine and analyze the problem. The result shows that rainfall will decrease in both methods but the liner method gives a higher value. from plotting time series of annual rainfall see that very variation so 5- moving average made to reduce the variance of rain but still variations so second 5- moving average made give less variance for rain then teak liner trend the result show also trend will decrease but reach 125 mm less than liner trend of actual series.
Focused Ultrasound Neuromodulation On A Multiwell MEA
Authors: Saccher Marta , Kawasaki Shinnosuke , Onori Martina Proietti , Woerden Geeske van , Giagka Vasiliki , Dekker Ronald 
Published: November 2021

Abstract
Background: Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation methods will greatly enhance the application range of MEAs to study their effects on neurons. A neuromodulation method that is recently gaining more attention is focused ultrasound neuromodulation (FUS), which has the potential to treat neurological disorders reversibly and precisely. Methods: In this work, we present the integration of a focused ultrasound delivery system with a multi-well MEA plate. Results: The ultrasound delivery system was characterised by ultrasound pressure measurements, and the integration with the MEA plate was modelled with finite-element simulations of acoustic field parameters. The results of the simulations were validated with experimental visualisation of the ultrasound field with Schlieren imaging. In addition, the system was tested on a murine primary hippocampal neuron culture, showing that ultrasound can influence the activity of the neurons. Conclusions: Our system was demonstrated to be suitable for studying the effect of focused ultrasound on neuronal cultures. The system allows reproducible experiments across the wells due to its robustness and simplicity of operation.
Human Adipose Mesenchymal Stem Cells Modulate Inflammation and Angiogenesis Through Exosomes
Authors: Heo June Seok , Kim Sinyoung 
Published: November 2021

Abstract
Stem cell-derived exosomes are efficient and safe therapeutic tools for transferring endogenous biological cargo or functional biomolecules for regenerative medicine. The regulation of inflammation and angiogenesis plays a pivotal role in wound healing and tissue regeneration. The purpose of this study was to investigate the anti-inflammatory and pro-angiogenic roles of human adipose mesenchymal stem cell-derived exosomes, focusing on the underlying mechanisms. Exosomes inhibited LPS-induced inflammation by activating ROCK1 and PTEN expression. Moreover, microRNAs (miR-132 and miR-146a) released from exosomes upregulated the expression of pro-angiogenic genes and promoted proliferation activity and tube formation in human umbilical vein endothelial cells. Exosomal effects were verified using ROCK1/PTEN inhibitors for anti-inflammation and miR-132/miR-146a inhibitors for pro-angiogenesis. Our findings suggest that exosomes exert anti-inflammatory effects by targeting the ROCK1/PTEN pathway and exhibit pro-angiogenic effects via delivery of miR-132 and miR-146a. Taken together, these results suggest that exosomes may be promising therapeutic candidates for curing diseases involved in inflammation and angiogenesis.
RainCast: A Rapid Update Rainfall Forecasting System for New Zealand
Authors: Zhang Sijin , Barrow Gerard , Soltanzadeh Iman , Rye Graham , Zhan Yizhe , Webster Chris , Noble Chris 
Published: November 2021

Abstract
RainCast is a rapid update forecasting system that has been developed to improve short-range rainfall forecasting in New Zealand. This system blends extrapolated nowcast information with multiple forecasts from numerical weather prediction (NWP) models to generate updated rain forecasts every hour. It is demonstrated that RainCast is able to outperform the rainfall forecasts produced from NWP systems out to 24 hours, with the greatest improvement in the first 3-4 hours. The limitations of RainCast are also discussed, along with recommendations on how to further improve the system.
The Influence of Acetabular Morphologic Variations on the Cup Position in Total Hip Arthroplasty for Crowe type III Dysplastic Hip
Authors: Shen Junmin , Zhang Ti , Dong Yu , Zhang Yanchao , Zhou Yonggang , Guo Lingfei 
Published: November 2021

Abstract
Background: We aimed to (1) evaluate the acetabular morphologic variations of Crowe III hips; (2) study the influence of different morphologies on the cup position in total hip arthroplasty.Methods: From November 2008 to February 2019, we retrospectively evaluated 101 patients (110 hips) with Crowe III developmental dysplasia of the hip. We classified Crowe III hips into two subtypes, the IIIA when the acetabular roof was extensively deficient and the junction between the false and the true acetabulum was indistinct, and the IIIB when there is a significant crest between the false and the true acetabulum. Based on the radiographs, we measured the morphological characteristic of the acetabulum and the postoperative cup position.Results: The false acetabulum of IIIB hips had larger Tonnis angle and smaller center-edge angle than the IIIA hips. The width of true acetabular roof in the IIIB hips was thicker than the IIIA group. Fifty-one (100%) IIIA hips and 48 (81.4%) IIIB hips were reconstructed using high hip center while 11 (18.6%) IIIB hips were reconstructed anatomically. The mean vertical distance of center of rotation in the IIIA group was 33.5±4.5 mm while it was 31.2±6.3 mm in the IIIB group (p=0.040). The vertical distance of the hip center was positively correlated with the height of dislocation in the IIIA group (r=0.493, p<0.001). According to the four-zone system, in the IIIA group, 5 hips were located in the inferomedial zone, 23 hips in the superomedial zone, 22 hips in the superolateral zone and 1 hip in the inferolateral zone. In the IIIB group, the corresponding numbers were respectively 15, 17, 1 and 5. Compared with the IIIA group, there were more IIIB hips located in the inferomedial zone (p=0.008) and less in the superolateral zone (p=0.033).Conclusions: There are distinct morphologic subtypes based on the relationship between the false and the true acetabulum. More bone stock located in the superior wall of the true acetabulum can bring more possibilities for anatomical reconstruction, and lower the height of center of rotation when using high hip center.
Improved Artificial Neural Network Grid Synchronization Technique for Three-Phase Grid Systems based on Synthesis Segmental Multilevel Converter
Authors: Rajendran Nirmala , Sundharajan Venkatesan 
Published: November 2021

Abstract
The solar Photovoltaic (PV) systems have gained a significant attention due to its easy implementation and availability. In which, the proper energy management should be mainly concentrated for a successful PV power utilization. In the traditional works, various controlling techniques have been developed for reactive power compensation. But, it lacks with the issues related to reduced system performance, increased loss, and high harmonics. To solve these issues, this paper aims to develop a new controlling methodology, named as Synthesis Segmental Multilevel Converter (SSMC) for reactive power compensation in a three phase grid systems. Initially, it extracts the maximum power from the solar PV systems by using an Enhanced Perturb and Observe (EPO) method. The panel separation is done and the three phase power input is given to the SSMC converter, where the synchronization and switching pulse generation processes are performed. During synchronization, integrated techniques such as Proportional Integral (PI), Fuzzy Logic Controller (FLC), and Improved Artificial Neural Network (IANN) techniques are utilized to maintain the voltage, magnitude and phase angle in a same level. Consequently, the Inductance Capacitance (LC) filtering technique is applied to reduce the harmonics distortion in the signal. After that, the Park transformation is used to perform the dq0 to abc transformation, which is implemented for reducing the high volume of error. Finally, the error free signal is fed to the three phase grid system with reduced harmonics also both the simulation and analytical results have been taken for analyzing the performance of the proposed technique.
Task Optimization Leads to Human-like Top-down and Bottom-up Attention during Reading Comprehension
Authors: Zou Jiajie , Ding Nai 
Published: November 2021

Abstract
Attention is a complex system involving multiple interactive components that jointly regulate information processing in the brain. It has been hypothesized that the computational goal of attention is to optimally integrate information under task demands, and evidence has been provided in relatively simple learning and decision making tasks. It remains unclear, however, whether this hypothesis can explain attention distribution in more complex real-world tasks that engage multiple attention systems. Here, taking advantage of the development of attention mechanisms in deep neural network (DNN) models, we investigate whether human attention during real-world reading comprehension tasks can be explained as a consequence of task optimization. In a goal-directed reading task, participants read a passage to answer a question. Eye tracking results show that the attention on each word, quantified by the fixation time, is modulated by both the top-down reading goal and lower-level visual layout and textual features. When trained to perform the same goal-directed reading task, DNN models yield human-level performance and naturally evolve human-like attention distribution, with deep layers tuned to the reading goal and shallow layers tuned to textual features. Further experiments suggest that different training tasks separately contribute to goal-directed and text-based attention. In summary, the results strongly suggest that human attention can be interpreted as a consequence of task optimization during real-world reading tasks.
The New Phi Function and some of it's Applications
Authors: Das Prithwis 
Published: November 2021

Abstract
In Mathematics, we see a large number of functions, each having its own properties. Some of these are very interesting and contribute greatly to the intensive research in the field of Mathematics. This paper deals with one such function (which we have termed as the phi function) which emerges from a chain of inequalities, established from the basic concepts of differential calculus. This paper establishes several inequalities which relate to functions and their integrals. Another important expression (from the point of view of notations) links a class of divergent infinite series to the phi function. Finally, we will dive into a brief overview of the phi-form of plane trigonometric functions and derive the trigonometric identity sin2(θ) + cos2(θ) = 1, thus marking their importance. Throughout the paper, we will be analyzing functions in R+ such that the functions are always greater than 0. We will also consider that the functions are continuous and differentiable in the intervals under consideration.
A Comprehensive Study of Large Negative Dispersion and Highly Nonlinear Perforated Core PCF: Theoretical Insight
Authors: Upadhyay Anurag , Singh Shivam , Sharma Divya , Taya Sofyan A 
Published: November 2021

Abstract
A novel photonic crystal fiber (PCF) containing circularly organized square-shaped air holes in the cladding region is investigated. The fiber core is perforated with four circular air-filled holes to instate high nonlinearity and large negative dispersion. The numerical analysis is done with a finite element method based COMSOL Multiphysics tool to investigate different optical properties of the propounded PCF. Simulation outcome verifies a high nonlinear coefficient value of 300 W-1 Km-1 which is the highest ever achieved value without using any nonlinear materials or liquids to the best of our knowledge. In parallel, a maximum negative chromatic dispersion of -1689 ps/nm/km is achieved. Moreover, birefringence, numerical aperture, and propagation loss are also measured as 2.40×10-3, 0.59, and 4.12×10-11 dB/m respectively along with an extremely high core power fraction of 99.98%. Hence, the propounded PCF is suitable for residual dispersion compensation, supercontinuum generation, and high bitrate transmission.
The Correlation between IgM and IgG Antibodies with Blood Profile in Patients Infected with COVID 19
Authors: Alibolandi Zahra , Ostadian Amirreza , Sayyah Saeed , Kashani Hamed Haddad , Ehteram Hassan , Banafshe Hamid Reza , Hajijafari Mohammad , Sepehrnejad Mahdi , Kashani Narjes Riahi , Azadchehr Mohammd-Javad , Nikzad Hossein , Hosseini Elahe Seyed 
Published: November 2021

Abstract
Objectives: This study aimed to determine the levels of IgM and IgG antibody response to the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with different disease severity.Methods: IgM and IgG antibody levels were evaluated via enzyme-linked immunosorbent assay (ELISA). In total, 100 patients with confirmed SARS-CoV-2 infection were enrolled in this study and viral RNA was detected by using Real-time PCR technique. Clinical and laboratory data were collected and analyzed after hospital admission for COVID-19 and two months post-admission. Results: The level of anti-SARS-CoV-2 antibody IgG was significantly higher in the severe patients than those in moderate and mild groups, 2 months after admission. Also, level of IgG was positively associated with increased WBC, NUT and LYM counts in sever than mild or moderate groups after admission to hospital.Conclusion: Our findings suggested that patients with severe illness might experience longer virus exposure times and have a stronger antibody response against viral infection. Thus, they have longer time immunity compared with other groups.
BcMF27 , a Pectin Methylesterase Gene, Regulates Pollen Development And Pollen Tube Growth in Brassica Campestris
Authors: Yue Xiaoyan , Cao Jiashu 
Published: November 2021

Abstract
Functional pollen grains are an essential ingredient of successful reproduction in flowering plants and are protected by outer walls. Pectin methylesterases (PMEs) modify pectin, a structural component of pollen intine. However, there are few studies on PMEs. Artificial microRNA (amiRNA) and overexpression technology was performed to investigate the function of pollen-specific PME gene, BcMF27, in pollen development. Knockdown of BcMF27 led to pollen wall collapse, 20% of which unknown material adhered to. Wall-collapsed pollen had abnormally thick intine outside of the germinal furrows. A portion of the cytoplasm was degraded in the remaining pollen with unknown material on the wall, in addition to a thick intine. Overexpression of BcMF27 resulted in 66.67% pollen wall disruption, causing an abnormally thick intine. In addition, functional interruption of BcMF27 gave rise to pollen tubes twisted in vitro. Taken together, BcMF27 contributes to the intine morphogenesis during pollen development and stabilizes pollen tube elongation. This research can promote knowledge of PMEs function and the molecular mechanism in pollen wall construction.
JQ1 Synergize with Anti-CD47 Antibody to Enhance the Function of Macrophages and Repress the Progression of Burkitt Lymphoma
Authors: Wang Shunan , Guo Wei , Zhao Yangzhi , Li Jia , Wan Xin , Liu Zhihe , Song Wantong , Bai Ou 
Published: November 2021

Abstract
Background: M2 macrophages, as the most prominent immune cells in Burkitt lymphoma (BL), are promising targets and anti-CD47 antibody could enhance the phagocytosis but be unable to eradicate tumor cells. JQ1, a C-MYC inhibitor, may enhance the function of macrophages and be a choice for combination therapy. Methods: The effect JQ1, on the expression of CD47 was measured. Then the synergy of JQ1 and anti-CD47 antibody was measured using phagocytosis assays. The effect of JQ1 on the polarization of macrophages was also detected. Finally, the efficiency and safety of JQ1 and anti-CD47 antibody combination therapy was explored in a groin orthotopically implanted Raji tumor model. Results: JQ1 could suppress the expression of CD47 on the surface of BL cells, thus synergize with anti-CD47 antibody to enhance the phagocytosis of macrophages. JQ1 could polarize macrophages from M2 to M1 while inhibiting the proliferation, inducing the apoptosis and blocking the cell cycle of BL cells. Finally, JQ1 and anti-CD47 antibody combination therapy could repress the progression of BL in NOD/SCID mice. Conclusions: Macrophages may be a promising target in BL and JQ1 combined with anti-CD47 antibody may be a potential therapeutic choice, providing theoretical basis for the use of this new targeted immunotherapy in clinical practice.
Application of Failure Detection Methods to Detect Information Attacks on the Control System
Authors: Radda Iureva , Alexey Margun 
Published: November 2021

Abstract
The paper examines the influence of information attacks on the dynamics of automatic control systems. Comparison of abnormal dynamics of control objects during attacks and device failures is carried out. The similarity of the consequences of information attacks and failures of the control system is analyzed, a method for identifying attacks based on the methods developed for detecting failures is developed. Computer modeling of the influence of information attacks and failures on the control system of a DC motor has been carried out. The simulation results allow making a conclusion about the applicability of the failure detection algorithms for detecting attacks.
Has-miR-875-5p Inhibits Tumorigenesis By Targeting USF2 Via TGF-β Signaling Pathway in Gastric Cancer
Authors: Gao Shenshuo , Zhang Zhikai , Wang Xubin , Ma Yan , Li Chensheng , Liu Hongjun , Jing Changqing , Li Leping , Guo Xiaobo 
Published: November 2021

Abstract
Background: Gastric cancer (GC) is one of the most common malignancies, and more and more evdiences show that the pathogenesis is regulated by various miRNAs. In this study, we investigated the role of miR-875 in GC. Methods: The expression of miR-875-5p was detected in human GC specimens and cell lines by miRNA RT-PCR. The effect of miR-875-5p on GC proliferation was determined by CCK-8 proliferation assay and EDU assay. Migration and invasion were examined by transwell migration and invasion assay and wound healing assay. The interaction between miR-875-5p and its target gene USF2 was verified by a dual luciferase reporter assay. The effects of miR-875-5p in vivo were studied in xenograft nude mice models. Related proteins were detected by Western blot. Results: The results showed that miR-875-5p inhibited the proliferation, migration and invasion of gastric cancer cells in vitro, and inhibited tumorigenesis in vivo. USF2 proved to be a direct target of miR-875-5p. Knockdown of USF2 partially counteracts the effects of miR-875-5p inhibitors. Overexpression of miR-875-5p can inhibit proliferation, migration, and invasion through the TGF-β signaling pathway by down-regulation of USF2 in GC, providing a new research direction for the diagnosis and targeted therapy of GC.Conclusions: MiR-875-5p can inhibited the progression of GC by directly targeting USF2 and negatively regulating TGF-β signaling pathway. In the future, miR-875-5p is expected to be used as a potential therapeutic target for GC therapy.