bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is OTT Video a Substitute for TV? Policy Insights from Cord-Cutting
Authors: Malone Jacob B. , Nevo Aviv , Nolan Zachary , Williams Jonathan W. 
Published: November 2021

Abstract
The video entertainment industry is experiencing increases in over-the-top (OTT) video usage and cord-cutting behavior. Using unique panel data from 2012–2016, we document the behavior of the 2.4% of households who “cut the cord” annually. After dropping TV, these households increase internet usage by 22%, reduce payments to multiple-system operators (MSOs) by 50%, and 16% acquire new OTT video subscriptions. These results indicate meaningful substitution between OTT video and TV and suggest that competition authorities should consider broadening market definitions. MSOs appear to have little incentive to degrade OTT video, despite OTT video's contribution to declining TV revenues.
Ethiopian Federalism: Philosophical and Institutional Design Limitations and a Case for Loose Federalism
Authors: Gebreslassie Seife Hailu 
Published: November 2021

Abstract
This article attempts to answer the question: is Ethiopian federalism sustainable? Once deemed a thought vanguard of building Ethiopia as a new ‘multi-national’ state, existing philosophical and institutional design limitations are increasingly making its sustainability problematic amidst the revival of its rival alternatives-unitarism and secessionism. This article argues for re-inventing the system in the spirit of loose federalism, ensuring its continued relevance to the fast changing political climate in Ethiopia. To this end, it calls for a robust revisit, re-negotiation and redesign of i) distribution of self-rule and shared rule powers, ii) vertical and horizontal inter-governmental relations, and iii) House of Federation of the system.
A central challenge is how to secure sufficient political trust between the federal and regional governments and among the regional governments of the federation. This requires a ‘workable platform and rules of the game’ for running a smooth grand elite bargaining process.
The Privatization of Human Research Ethics: An American Story
Authors: Babb Sarah 
Published: November 2021

Abstract
In recent decades, there has been a remarkable shift in the governance of human research ethics in the United States. A model once based on review by panels of local volunteers has given way to a system dominated by large, for-profit research ethics committees. America’s reliance on for-profit ethics review is unique among wealthy industrialized countries. How can we account for this anomaly? In this article, I show that for-profit irb s represent only the most visible aspect of the privatization of human research protections in the United States. I suggest that private institutions have emerged as “workaround” solutions to systemic problems, in the absence of comprehensive policy reforms.
Tropical Cyclone Flooding in the Carolinas
Authors: Liu Maofeng , Smith James A. , Yang Long , Vecchi Gabriel A. 
Published: November 2021

Abstract
The climatology of tropical cyclone flooding in the Carolinas is analyzed through annual flood peak observations from 411 U.S. Geological Survey (USGS) stream gauging stations. Tropical cyclones (TCs) account for 28% of the top 10 annual flood peaks, 55% of record floods, and 91% of floods with peak magnitudes at least 5 times greater than the 10-yr floods, highlighting the prominent role of TCs for flood extremes in the Carolinas. Of all TC-related flood events, the top 10 storms account for nearly 1/3 of annual flood peaks and more than 2/3 of record floods, reflecting the dominant role of a small number of storms in determining the upper tail of flood peak distributions. Analyses of the 10 storms highlight both common elements and diversity in storm properties that are responsible for flood peaks. Extratropical transition and orographic enhancement are important elements of extreme TC flooding in the Carolinas. Analyses of the Great Flood of 1916 highlight the flood peak of 3115 m3 s−1 in French Broad River at Asheville, 2.6 times greater than the second-largest peak from a record of 124 years. We also examine the hydroclimatology, hydrometeorology, and hydrology of flooding from Hurricanes Matthew (2016) and Florence (2018). Results point to contrasting storm properties for the two events, including tracks as well as rainfall distribution and associated physical mechanisms. Climatological analyses of vertically integrated water vapor transport (IVT) highlight the critical role of anomalous moisture transport from the Atlantic Ocean in producing extreme rainfall and flooding over the Carolinas.
Clinical Treatment of Perioperative Disseminated Intravascular Coagulation in Patients Who Underwent Gastrointestinal and Hepato-Biliary-Pancreatic Surgery
Authors: Tomioka Kodai , Aoki Takeshi , Matsuda Kazuhiro , Enami Yuta , Fujimori Akira , Koizumi Tomotake , Kusano Tomokazu , Date Hiromi , Yamashita Takeshi , Ariyoshi Tomotake , Goto Satoru , Yamazaki Kimiyasu , Watanabe Makoto , Otsuka Koji , Murakami Masahiko 
Published: November 2021

Background It is unclear how effective recombinant thrombomodulin (rTM) treatment is in disseminated intravascular coagulation (DIC) during the perioperative period of gastrointestinal and hepato-biliary-pancreatic surgery. The current study aimed to evaluate the therapeutic outcomes of rTM for perioperative DIC. Methods We enrolled 100 consecutive patients diagnosed with perioperative DIC after gastrointestinal surgery, and hepato-biliary-pancreatic including emergency procedures, between January 2012 and May 2021. Patients received routine rTM treatment immediately after DIC diagnosis. Then, the DIC, Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were calculated and used for evaluation. The outcomes of rTM treatment and the predictors of survival were evaluated. Results The causative diseases of DIC were as follows: perforated peritonitis, n = 38; intestinal ischemia, n = 23; intra-abdominal abscess, n = 13; anastomotic leakage, n = 7; pneumonia, n = 7; cholangitis, n = 4; and others, n = 6. The 30-day mortality rate was 18.0%. There were significant differences in the platelet count (13.78 vs 10.41, P = .032) and the SOFA score (5.22 vs 9.89, P<.0001) at the start of DIC treatment between the survivor and non-survivor groups (day 0). The survivor group had a significantly lower DIC score (3.13 vs 4.93, P = .0006) and SOFA score (4.94 vs 12.14, P < .0001) and a higher platelet count (13.50 vs 4.34, P < .0001) than the non-survivor group on day 3. Conclusions Comprehensive and systemic treatment is fundamentally essential for DIC, in which rTM may play an important role in the treatment of perioperative DIC.
We are all institutionalized: Three works to challenge the conceit of a generically ‘academic’ study of religion
Authors: Wolfart Johannes 
Published: November 2021

This essay encounters and considers together three very different recent works by scholars of religion, each one with strong Canadian connections: Maureen Matthews, Aaron Hughes and Donald Wiebe. The primary purpose, however, is to illuminate more broadly the importance of institutional dynamics in the formation and operation of the academic study of religion (i.e., not just in Canada). This stands in contrast to a well-established pattern of debating supposedly loftier questions of naming, disciplinary identity, idealized mandates and limits, etc. Furthermore, this essay suggests that scale of investigation matters – with a local, single-institution study revealing more, perhaps, about how we really do our work than either national or transnational efforts. In the end, reading these three books together suggests a tremendous diversity, including dynamic institutional diversity, in academic approaches to religion: scientific and non-scientific (predictably) but also, disciplined or expert and non-expert or academic administrative. Thus, the essay enjoins readers to take seriously a distinction between domains of ‘distributive’ and ‘concentrated’ expertise within the academy (e.g., Religious Studies versus, say, Civil Engineering), as well as the development of patterns of ‘altero-piety’ across the expert/nonexpert divide. In the end, such murky institutional dynamics appear to be shaping and impelling our field from the local institutional level (e.g., at the University of Winnipeg as documented by Matthews) to the transnational institutional level (e.g., in the International Association for the History of Religions as documented by Wiebe). Ultimately, one must conclude that stipulating that Religious Studies entail the academic study of religion is meaningless. ‘The academy’ is no more universal and unique ( sui generis?) than ‘religion’ itself. Rather, academic institutions are diverse and particular; and yet a variety of factors, ranging from deep colonial histories to the current global political economy of postsecondary higher education, all work to conceal the importance of the institutional basis of Religious Studies. Put another way (and pace Jonathan Z Smith): religion certainly is a creation of the scholar’s study – yet, far from imagining this scholar’s study as a place set apart (as it were), we must start imagining it as a historical, social and institutional location. That would take us one small but further step towards the all-important goal of disciplinary ‘reflexivity”.
Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
Authors: Arcadi Francesca Antonia , Corallo Francesco , Torrisi Michele , Scarfì Chiara , Lo Buono Viviana , Formica Caterina , Bramanti Placido , Marino Silvia , Bonanno Lilla , De Cola Maria Cristina 
Published: November 2021

Objective To compare selective serotonin reuptake inhibitors (SSRIs) and nootropic drugs in the reduction of anxiety and depressive symptoms in post-stroke patients. Methods This retrospective cohort study included patients diagnosed with post-stroke depression that were treated with either SSRIs or nootropic drugs (i.e. citicoline or choline alphoscerate). Depression and anxiety were assessed using the Hamilton Rating Scales. Statistical associations between the use of nootropic drugs and mood disorder improvements were determined by measuring assessment scores at 6-months. Results A total of 44 post-stroke patients with depression (aged 45–75 years) were enrolled in the study: 20 were treated with SSRIs and 24 received nootropic drugs. From baseline to follow-up, the SSRI group showed a large effect size with regard depression (success rate difference [SRD] 0.57; 95% confidence interval [CI] 0.21, 0.79) and anxiety (SRD 0.49; 95% CI 0.14, 0.74), whereas the nootropic group showed a small effect size for depression (SRD 0.16; 95% CI –0.17, 0.46) and a small effect size for anxiety (SRD 0.36; 95% CI –0.03, 0.62). Conclusion The administration of nootropic drugs could be a valid therapeutic strategy to manage post-stroke patients suffering from mild–moderate anxiety or anxious-depressive syndrome, but this requires further research.
Seven-year follow-up of a novel 360-degree implant (annular intracorneal inlay) plus accelerated corneal cross-linking: A case study
Authors: Mohammadpour Mehrdad , Khorrami-Nejad Masoud , Heirani Mohsen 
Published: November 2021

Aim to report late visual, refractive, and tomographic findings of a patient with progressive keratoconus (KCN) over 7-year follow-up examinations after treatment with an advanced intrastromal implant known as annular intracorneal inlay (AICI) combined with accelerated corneal cross-linking (ACXL). Methods Slit-lamp photography of anterior segment, corneal tomography maps, and manifest refractions were recorded. Results A 30-year-old female presented with the complaint of gradual decreased visual acuity in recent years that was remarkable in her left eye (LE). After clinical examinations, she underwent AICI implantation plus ACXL on her LE. Seven years later, notable improvements were observed in some visual, refractive, and tomographic parameters. The most obvious change was ascribed to the uncorrected distance visual acuity (UDVA) that was 1.3logMAR and 0.4logMAR, before and 7 years after the operation, respectively. However, the preoperative corrected distance visual acuity (CDVA) improved slightly from 0.3logMAR to 0.22logMAR after 7 years. The values of anterior K-max, mean-K, flat-K, and steep-K were flattened by 1.80 D, 1.10 D, 1.00 D, and 1.30 D, respectively. Most visual, refractive, and tomographic data improved or remained stable after 7 years and no remarkable ocular complication was observed at the end of the 7th year. Conclusion AICI implantation plus ACXL could be considered as a safe and effective strategy in halting the KCN progression and improving the visual and tomographic properties of the KCN patients. However, future prospective studies with more participants are needed to evaluate the potential effect of AICI implantation on KCN progression.
Global white matter structural integrity mediates the effect of age on ischemic stroke outcomes
Authors: Etherton Mark R , Schirmer Markus D , Zotin Maria Clara Zanon , Rist Pamela M , Boulouis Gregoire , Lauer Arne , Wu Ona , Rost Natalia S 
Published: November 2021

Background The relationship of global white matter microstructural integrity and ischemic stroke outcomes is not well understood. Aims To investigate the relationship of global white matter microstructural integrity with clinical variables and functional outcomes after acute ischemic stroke. Methods A retrospective analysis of neuroimaging data from 300 acute ischemic stroke patients with magnetic resonance imaging brain obtained within 48 hours of stroke onset and long-term functional outcomes (modified Rankin, mRS) was performed. Peak width of skeletonized mean diffusivity (PSMD), as a measure of global white matter microstructural injury, was calculated in the hemisphere contralateral to the acute infarct. Multivariable linear and logistic regression analyses were performed to identify variables associated with PSMD and excellent functional outcome (mRS < 2) at 90 days, respectively. Mediation analysis was then pursued to characterize how PSMD mediates the effect of age on acute ischemic stroke functional outcomes. Results White matter hyperintensity volume, age, pre-stroke disability, and normal-appearing white matter mean diffusivity were independently associated with increased PSMD. In logistic regression analysis, increased infarct volume and PSMD were independent predictors of excellent functional outcome. Additionally, the effect of age on functional outcomes was indirectly mediated by PSMD ( P < 0.001). Conclusions As a marker of global white matter microstructural injury, increased PSMD mediates the effect of increased age to contribute to poor acute ischemic stroke functional outcomes. PSMD could serve as a putative radiographic marker of brain age for stroke outcomes prognostication.
The morphometric of lycopsid sporophylls and the evaluation of their dispersal potential: an example from the Upper Devonian of Zhejiang Province, China
Authors: Zhou Yi , Wang De-Ming , Liu Le , Huang Pu 
Published: November 2021

Abstract
Background
Previous studies have discussed the special structural adaptations of Late Palaeozoic lycopsids, for example, the dispersal potential of reproductive organs. Based on materials from the Upper Devonian Wutong Formation in Changxing County, Zhejiang Province, China, we now analyze the morphometric and perform some calculation to evaluate the dispersal of sporophyll units of lycopsids.

Results
The fossil sporophyll units are divided into two types in view of obvious difference in shape and we name two new (form) species for them. We also analyze the falling process and give the calculation method of dispersal distance.

Conclusions
The fossil sporophyll units show relatively poor potential of wind dispersal compared with modern samaras, and show potential adaptation to the turbulent environment.
Transcriptome profiling reveals the developmental regulation of NaCl-treated Forcipomyia taiwana eggs
Authors: Chen Mu-En , Tsai Mong-Hsun , Huang Hsiang-Ting , Tsai Ching-Chu , Chen Mei-Ju , Yang Da-Syuan , Yang Teng-Zhi , Wang John , Huang Rong-Nan 
Published: November 2021

Abstract
Background
The biting midge, Forcipomyia taiwana, is one of the most annoying blood-sucking pests in Taiwan. Current chemical control methods only target the adult, not the immature stages (egg to pupa), of F. taiwana. Discovering new or alternative tactics to enhance or replace existing methods are urgently needed to improve the effectiveness of F. taiwana control. The egg is the least understood life stage in this pest species but may offer a novel point of control as addition of NaCl to the egg environment inhibits development. Thus, the objective of this study was to use RNA profiling to better understand the developmental differences between wild-type melanized (black) and NaCl-induced un-melanized (pink), infertile F. taiwana eggs.

Results
After de novo assembly with Trinity, 87,415 non-redundant transcripts (Ft-nr) with an N50 of 1099 were obtained. Of these, 26,247 (30%) transcripts were predicted to have long open reading frames (ORFs, defined here as ≥300 nt) and 15,270 (17.5%) transcripts have at least one predicted functional domain. A comparison between two biological replicates each of black and pink egg samples, although limited in sample size, revealed 5898 differentially expressed genes (DEGs; 40.9% of the transcripts with long ORFs) with ≥2-fold difference. Of these, 2030 were annotated to a Gene Ontology biological process and along with gene expression patterns can be separated into 5 clusters. KEGG pathway analysis revealed that 1589 transcripts could be assigned to 18 significantly enriched pathways in 2 main categories (metabolism and environmental information processing). As expected, most (88.32%) of these DEGs were down-regulated in the pink eggs. Surprisingly, the majority of genes associated with the pigmentation GO term were up-regulated in the pink egg samples. However, the two key terminal genes of the melanin synthesis pathway, laccase2 and DCE/yellow, were significantly down-regulated, and further verified by qRT-PCR.

Conclusion
We have assembled and annotated the first egg transcriptome for F. taiwana, a biting midge. Our results suggest that down-regulation of the laccase2 and DCE/yellow genes might be the mechanism responsible for the NaCl-induced inhibition of melanization of F. taiwana eggs.
Linkage and QTL mapping for tuber shape and specific gravity in a tetraploid mapping population of potato representing the russet market class
Authors: Park Jaebum , Massa Alicia N. , Douches David , Coombs Joseph , Akdemir Deniz , Yencho G. Craig , Whitworth Jonathan L. , Novy Richard G. 
Published: November 2021

Abstract
Background
Tuber shape and specific gravity (dry matter) are important agronomic traits in potato processing and impact production costs, quality, and consistency of the final processed food products such as French fries and potato chips. In this study, linkage and QTL mapping were performed for these two traits to allow for the implementation of marker-assisted selection to facilitate breeding efforts in the russet market class. Two parents, Rio Grande Russet (female) and Premier Russet (male) and their 205 F1 progenies were initially phenotyped for tuber shape and specific gravity in field trials conducted in Idaho and North Carolina in 2010 and 2011, with specific gravity also being measured in Minnesota in 2011. Progenies and parents were previously genotyped using the Illumina SolCAP Infinium 8303 Potato SNP array, with ClusterCall and MAPpoly (R-packages) subsequently used for autotetraploid SNP calling and linkage mapping in this study. The 12 complete linkage groups and phenotypic data were then imported into QTLpoly, an R-package designed for polyploid QTL analyses.

Results
Significant QTL for tuber shape were detected on chromosomes 4, 7, and 10, with heritability estimates ranging from 0.09 to 0.36. Significant tuber shape QTL on chromosomes 4 and 7 were specific to Idaho and North Carolina environments, respectively, whereas the QTL on chromosome 10 was significant regardless of growing environment. Single marker analyses identified alleles in the parents associated with QTL on chromosomes 4, 7, and 10 that contributed to significant differences in tuber shape among progenies. Significant QTL were also identified for specific gravity on chromosomes 1 and 5 with heritability ranging from 0.12 to 0.21 and were reflected across environments.

Conclusion
Fully automated linkage mapping and QTL analysis were conducted to identify significant QTL for tuber shape and dry matter in a tetraploid mapping population representing the russet market class. The findings are important for the development of molecular markers useful to potato breeders for marker-assisted selection for the long tuber shape and acceptable dry matter required by the potato industry within this important market class.
Genome and transcriptome-based characterization of high energy carbon-ion beam irradiation induced delayed flower senescence mutant in Lotus japonicus
Authors: Du Yan , Luo Shanwei , Zhao Jian , Feng Zhuo , Chen Xia , Ren Weibin , Liu Xiao , Wang Zhuanzi , Yu Lixia , Li Wenjian , Qu Ying , Liu Jie , Zhou Libin 
Published: November 2021

Abstract
Background
Flower longevity is closely related to pollen dispersal and reproductive success in all plants, as well as the commercial value of ornamental plants. Mutants that display variation in flower longevity are useful tools for understanding the mechanisms underlying this trait. Heavy-ion beam irradiation has great potential to improve flower shapes and colors; however, few studies are available on the mutation of flower senescence in leguminous plants.

Results
A mutant (C416) exhibiting blossom duration eight times longer than that of the wild type (WT) was isolated in Lotus japonicus derived from carbon ion beam irradiation. Genetic assays supported that the delayed flower senescence of C416 was a dominant trait controlled by a single gene, which was located between 4,616,611 Mb and 5,331,876 Mb on chromosome III. By using a sorting strategy of multi-sample parallel genome sequencing, candidate genes were narrowed to the gene CUFF.40834, which exhibited high identity to ethylene receptor 1 in other model plants. A physiological assay demonstrated that C416 was insensitive to ethylene precursor. Furthermore, the dynamic changes of phytohormone regulatory network in petals at different developmental stages was compared by using RNA-seq. In brief, the ethylene, jasmonic acid (JA), and salicylic acid (SA) signaling pathways were negatively regulated in C416, whereas the brassinosteroid (BR) and cytokinin signaling pathways were positively regulated, and auxin exhibited dual effects on flower senescence in Lotus japonicus. The abscisic acid (ABA) signaling pathway is positively regulated in C416.

Conclusion
So far, C416 might be the first reported mutant carrying a mutation in an endogenous ethylene-related gene in Lotus japonicus, rather than through the introduction of exogenous genes by transgenic techniques. A schematic of the flower senescence of Lotus japonicus from the perspective of the phytohormone regulatory network was provided based on transcriptome profiling of petals at different developmental stages. This study is informative for elucidating the molecular mechanism of delayed flower senescence in C416, and lays a foundation for candidate flower senescence gene identification in Lotus japonicus. It also provides another perspective for the improvement of flower longevity in legume plants by heavy-ion beam.