bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational Burnout, Psychological Status and Quality of Life in Primary Care Physicians Working in Outpatient Settings
Authors: Pogosova N. V. , Isakova S. S. , Sokolova O. Y. , Ausheva A. K. , Zhetisheva R. A. , Arutyunov A. A. 
Published: July 2021

Aim To study features of the psychological status, job burnout syndrome (JBS)m and quality of life (QoL) in outpatient physicians.Material and methods This cross-sectional study was performed at 16 randomly selected municipal outpatient hospitals of Moscow and included physicians (district physicians, primary care physicians, and cardiologists). The participants signed an informed consent form and then filled out a registration card that included major social and demographic (sex, age, education, position) and professional characteristics (specialization, work experience, qualification category), and questionnaires. The degree of job burnout was evaluated with the Maslach Burnout Inventory (MBI-HSS), and the presence of anxio-depressive symptoms was evaluated with the Hospital Anxiety and Depression Scale (HADS). The level of stress was assessed with a visual analogue scale (VAS) in a score range from 0 to 10. The QoL of physicians was assessed with the short version of the World Health Organization Quality of Life (HOQOL-BREF) questionnaire.Results This study included 108 physicians from 16 municipal outpatient clinics aged 24 to 70 years (mean age, 44.0±13.1 years), mostly women (87.0 %). Among JBS components, a high level of emotional exhaustion was observed in 50.0 % of physicians, a high level of depersonalization in 34.1 %, and a severe reduction of personal accomplishment in 37.5 %. A high level of stress (VAS score ≥7) was observed in 66.3 % of physicians; symptoms of anxiety and depression of any degree (HADS-A and HADS-D subscale score ≥ 8) were found in 23.8 and 22.7 % of participants, respectively. 42.0% of physicians evaluated their QoL lower than “good” and 41.6% of physicians evaluated their health condition lower than “good”. Most of the studied factors did not significantly depend on the gender and the duration of work, except for emotional exhaustion (55.3 % of women and 16.7 % of men; p=0.0086) and a high level of stress (72.2 % of women and 28.6 % of men; р=0.002).Conclusion The study showed a high prevalence of personal factors that potentially adversely affect the work of outpatient physicians. These factors included high degrees of stress, anxio-depressive symptoms, job burnout, unsatisfactory QoL, and low satisfaction with own health. Management decisions and actions are required to create the optimum psychological climate at the workplace of physicians, to develop new strategies for prophylaxis and correction of their psychological condition, and to implement comprehensive programs for improving the professional environment to maintain and enhance the mental health and to increase the professional prestige of the medical speciality.
Clinical observations of COVID-19 infection in patients with chronic thromboembolic pulmonary hypertension
Authors: Kamenskaya O. V. , Loginova I. Yu. , Klinkova A. S. , Lomivorotov V. V. , Chernyavsky A. M. 
Published: July 2021

Aim To present clinical observations of the novel coronavirus infection (COVID-19) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) after a surgical intervention in the form of thromobendarterectomy from pulmonary artery branches.Material and methods The Acad. E.N. Meshalkin National Medical Research Center performed 127 open surgical interventions for CTEPH in the form of thromobendarterectomy from 2016 through 2020. The present study enrolled 113 patients included into the follow-up care group and into the Center Registry who were followed up for more than 6 months after the surgery. Clinical and functional features of COVID-19 were evaluated in the studied group.Results In the follow-up care group, 5 (4.4%) postoperative CTEPH patients had COVID-19. One patient had asymptomatic disease, and others had typical clinical symptoms and bilateral polysegmental pneumonia. There were no cases requiring artificial ventilation and no lethal outcomes. All patients with COVID-19 received anticoagulants as a basis therapy for CTEPH, and two patients who had residual pulmonary arterial hypertension (PAH) additionally received a PAH-specific therapy. During the treatment of COVID-19, no adjustment of the anticoagulant or PAH-specific therapy was required.Conclusion The group of patients with CTEPH is a unique pathophysiological model for studying the effect of COVID-19 under the conditions of compromised pulmonary circulation. In the studied follow-up care group, the COVID-19 morbidity was 4.4 % without fatal outcomes. Evaluation of the role of chronic anticoagulant and PAH-specific therapy in COVID-19 postoperative patients as well as evaluation of the role of COVID-19 in CTEPH progression merit further investigation.
Results of Register in Patients with Acute Coronary Syndrome and Atrial Fibrillation Receiving Rivaroxaban
Authors: Baturina O. А. , Andreev D. A. , Sychev D.i A. , Mesitskaya D. F. , Andranovich S. V. , Babakova N. A. , Suvorov A. Yu. 
Published: July 2021

Aim To evaluate outcomes in patients with acute coronary syndrome and atrial fibrillation who receive rivaroxaban and the patients’ compliance with the antithrombotic therapy.Material and methods The study was performed from October 2017 through December 2019 and included 129 patients. Events between the discharge from the hospital and 12 months of follow-up were recorded. The primary endpoint was development of major, minor or requiring medical attention bleeding according to the TIMI scale. The secondary endpoint was a combination of recurrent myocardial infarction, nonfatal acute ischemic cerebrovascular disease, nonfatal systemic embolism, stent thrombosis, and cardiovascular mortality.Results 32 (24.8%) patients early terminated the antiplatelet treatment and 22 (17.1%) patients terminated the rivaroxaban treatment. 26 (20.2 %) patients had hemorrhagic complications. The highest incidence of hemorrhage was observed within the first 2 months after the discharge. None of the bleedings was fatal. Composite endpoint events were observed in 24 (18.6 %) patients, including 14 (10.9 %) who died from cardiovascular causes.Conclusion The compliance with the antiplatelet therapy was insufficient. The incidence of hemorrhagic complications was relatively high; minor and requiring medical attention hemorrhages mostly contributed to the structure of these complications. The observed incidence of recurrent ischemic events associated with a high mortality presents a more serious problem compared to hemorrhagic complications of the combination antiplatelet therapy and warrants a more aggressive tactics of the antiplatelet treatment in high-risk patients.
The ability of modern therapy to improve the prognosis of patients with HF: role of angiotensin neprilysin inhibitors and sodium-glucose cotransporter inhibitors
Authors: Mareev Yu. V. , Mareev V. Yu. 
Published: July 2021

Major principles for treatment of chronic heart failure with reduced left ventricular ejection fraction <40% (HFrEF) include a “triple neurohormonal blockade” as a main approach. However, in recent 6 years, two new classes of drugs for the treatment of HFrEF have appeared, which beneficially influence the prognosis. These drugs are angiotensin receptor neprilysin inhibitors (ARNI) and type 2 sodium-glucose cotransporter 2 (SGLT2) inhibitors.Aim To compare the net effect of simultaneous treatment with ARNI and SGLT2 inhibitors with the triple neurohormonal blockade in stable or decompensated patients with CHF based on Russian data.Material and methods We analyzed the risk of death per 100 patient-years in patients with HFrEF. Stable patients were followed up at the A.L. Myasnikov Institute of Cardiology (presently, A.L. Myasnikov Research Institute of Clinical Cardiology of the National Medical Research Center of Cardiology) from 2006 through 2007; data from the EPOCH-Decompensation-CHF study were used for decompensated patients (12.2 % and 36.8 %, respectively).Results When patients with stable HFrEF were successively switched from renin-angiotensin-aldosterone system (RAAS) inhibitors to ARNI (–16 %) and subsequently supplemented with SGLT2 (–13 %) the risk of death per 100 patient-years decreased from 12.2 % to 8.9 % (total risk decreased by 27 %; to save one patient the ARNI+ SGLT2 combination has to be prescribed to 30 patients). The estimated risk of death upon discharge from the hospital for the patients with decompensated CHF switched from RAAS inhibitors to ARNI (–16 %) and subsequently supplemented with SGLT2 (–13 %) was 26.9 deaths per 100 patient-years, whereas the number of patients to be treated for saving one life was only 10. Based on available data that demonstrate a greater effect of ARNI+ SGLT2 in patients immediately after CHF aggravation, the risk of death was recalculated. According to this analysis, the death rate per 1000 patient-years decreased from 36.8 to 19.9 % (relative risk decrease, 46 %), and to save one life only 6 patients had to be treated after they have achieved compensation of HFrEF.Conclusions This analysis shows the importance of early initiation of the ARNI+ SGLT2 therapy in patients with both decompensated and with stable HFrEF.
Evaluation of reproductive profile in male albino rats following varied duration of administration with Revive capsule
Authors: Ibama Onengiyeofori , Green Kinikanwo I. , Nwachuku Edna O. , Ben-Chioma Adline Erinma 
Published: July 2021

Background: Revive capsule is a polyherbal formulation commonly used to treat erectile dysfunction or enhance libido in men. Some of the individual herbs used in the formulation of this drug have been known scientifically to affect various biochemical components of the human body; hence this study was aimed at evaluating the reproductive profile in male albino rats following varied duration of administration with Revive capsule. Methods: A total of 42 male albino rats were used for the study, and were divided into six (6) groups of seven (7) rats each. They were allowed to acclimatize for two (2) weeks by maintaining 12-hour light and dark cycles daily, with access to standard feed and water ad libitum. Group A (negative control) rats were administered with distilled water once daily, while groups B, C, D, E and F were administered once daily with 72 mg/kg of Revive capsule for 1 week, 2 weeks, 3 weeks, 4 weeks and 6 weeks respectively. The rat dose administered was extrapolated from the human dose using the formula by Paget and Barnes. At the end of each treatment week, the rats were allowed to fast overnight, followed by their anaesthetization using chloroform, and blood sample collection via jugular vein puncture. Also, the testes were excised; the epididymis were also excised from the testes and used immediately for semen analysis, while the epididymis-free testes were examined histologically. Rat-specific test kits with ELISA method were used to analyze serum LH, FSH and testosterone.Results: The results showed a significant increase (p<0.05) in serum LH, FSH and testosterone levels, and a significant increase in sperm count and sperm quality parameters in the treatment groups compared to the negative control, with the maximum levels attained after 6 weeks of treatment (group F). Also, photomicrographs of histologically examined testes of the treatment groups appeared indifferent from those of the negative control.Conclusions: These findings may suggest that in using a rat model, treatment with Revive capsule at the appropriate dosage for 6 weeks is safe, and that, besides its acclaimed use in enhancing libido or treating erectile dysfunction, it may also be effective in promoting male fertility.
Dysgerminoma presenting at fifty, consequence to undiagnosed Swyer syndrome
Authors: Amin Sapna Vinit , Kumaran Aswathy 
Published: July 2021

Swyer syndrome or XY complete gonadal dysgenesis (CGD) is a rare disorder of sex development (DSD) characterized by presence of dysgenetic gonads in a phenotypically female patient with a male karyotype. Usually Swyer syndrome is diagnosed following appropriate evaluation for amenorrhea in adolescence and prophylactic gonadectomy is done as these patients have high risk of developing malignancy in their dysgenetic gonads. Here we presented patient who presented later in life with ovarian malignancy which turned out to be a consequence of undiagnosed Swyer syndrome. Her case exemplifies that fact that improper evaluation of primary amenorrhea in adolescence and omission to do prophylactic bilateral gonadectomy led to her presenting with malignancy at this advanced age. Therefore, be aware to not let Swyer syndrome go undiagnosed and mismanaged.
NOS ENREDOS DE VIVÊNCIAS DE ADEMAR VIDAL: CONSTRUÇÕES DE AFETIVIDADES E INTELECTUALIDADE
Authors: Marques Maria Joedna Rodrigues 
Published: July 2021

Este artigo faz parte de uma pesquisa desenvolvida em torno da obra e vida do intelectual paraibano Ademar Vidal (1897-1986). Para este texto, optamos por destacar a apresentação de alguns traços biográficos e do lugar social de Vidal, na intenção de compreender seu processo de erudição. Partimos da problematização do sujeito descrito por Alice Vidal no livro Ademar Vidal: para não esquecer (2010), destacamos o sujeito narrado e memorizado. Seguindo neste caminho, nos direcionamos para aspectos da sua formação intelectual, sua atuação em instituições, grupos sociais, trocas epistolares e encontros com outros intelectuais. Essas vivências e espaços influenciaram Ademar Vidal e sua produção no campo cultural, com ênfase nos estudos folclóricos da década de 1940 e consequentemente a formulação de uma identidade cultural para Paraíba. Dialogamos com Sérgio Vilas Boas (2008), Jean-François Sirinelli (2003) e Aleida Assmann (2011).
Study of incidence of heart failure in COPD exacerbation- A study in north India
Authors: Oli Ritamvara , Mishra J K , Srivastava G N , Mishra Saurabh , Brighten M 
Published: July 2021

Progression of chronic obstructive pulmonary disease has a considerable effect on heart function including pulmonary hypertension, cor-pulmonale, Right and Left sided heart dysfunction. As COPD and heart failure (HF) share a common clinical feature, delay in diagnosis is associated with increased mortality. We aimed to study the incidence of heart failure in patients with COPD exacerbation.142 patients were enrolled for study. It is a cross-sectional comparative study. We categorized exacerbation into two groups: respiratory failure and non-failure group. Patients were staged by spirometry after stabilization. Echocardigraphic evaluation and BNP levels were measured along with routine investigations.The mean age of the study group was 63.53±9.021. The overall incidence of heart failure in exacerbation of COPD patients in our study group was 33.09%(n=47). Incidence of HF was 50.6%(n=41) patients in the respiratory failure group and 9.8%(n=6) in non-respiratory failure group respectively. Right sided heart failure was recorded in 82.92% of case in group one whereas in group two 66.66% had left ventricular dysfunction.Our study concludes that overall incidence of heart failure in COPD exacerbation is 33.09%. Respiratory failure complicates heart failure and hence the incidence increases. Severe stages of disease are associated with Right sided heart failure more frequently.
Effectiveness of Self Regulation-Attachment Couple Therapy on Marital Commitment and Sexual Function of Women with Extramarital Affair
Authors: Shiri Fatemeh , Goudarzi Mahmoud , Moradi Omid , Ahmadian Hamzeh 
Published: July 2021

Aim: The purpose of this study was to determine the effectiveness of self regulation-attachment couple therapy on improving marital commitment and sexual function in women with extra-marital affair.
Methods: Semi-experimental research method with pre/post-test and control group including follow-up was used. The statistical population included women with extramarital affair referred to the counseling center for women in the city of Sanandaj, Iran. Using available sampling method, 30 subjects were selected and randomly assigned to experimental and control groups (15 participants each). Marital Commitment Questionnaire (Adams, Jones, 1997) and Women's Sexual Function Questionnaire (Rosen, Grandon, Myers, Hutty, 2004) were used. The intervention group received self regulation-attachment couple therapy through 8 ninety-minute sessions on a weekly basis. Data was analyzed using mixed analysis of variance.
Findings: Results showed that self regulation-attachment couple therapy programs significantly improved the marital commitment and sexual function. Follow-up analyses showed that these results remained stable after three months (P<0/001).
Conclusion: self regulation-attachment couple therapy approach by helping women achieve greater adjustment in relationship, dialogue and negotiation, increasing the ability to interact and improve the marital commitment and sexual function in women with extramarital affair.
Discussions: The findings of the present study show that studying counseling and internship in this field has influenced students’ views of marriage and marital relationships in various ways.
Investigating the Lived Experiences of Working Couples about Marital Conflicts: A Phenomenological Study
Authors: Rahimi Rohollah , Salimi Bajestani Hossien , Asgari Mohammad 
Published: July 2021

Aim: The purpose of this study was to extract the lived experiences of working couples from marital conflicts.
Methods: This study was conducted with a qualitative approach using interpretive phenomenology. In this study, researchers interviewed 12 working couples with marital conflicts using purposeful sampling. Interviews were analyzed using interpretive phenomenology.
Findings: Analyzing the data from the interviews led to the identification of the 14 main themes: financial conflict, inappropriate interactions in social media, lack of participation in house chores, ineffective communication, inability in reciprocal empathy and expression, lack of time management, conflict of roles and responsibilities, cognition vulnerability, adherence to gender stereotypes, inability to manage tasks at job and work environment, work-family conflict, power struggles, ultra-personal destructive factors and belief and ethical problems, 55 primary and 12 secondary themes in the lived experiences of working couples from marital conflicts.
Conclusion: A dual-career family is a place where couples are more likely to enter into marital conflicts if they do not realize fairness in various areas of family and work. The results of the present study showed that the families of career couples may be a high-risk group in terms of conflict, and this factor indicates the need for a negotiating role in the relationship between this type of couple. This highlights the need for special couple therapy for these couples. The results of the present study also showed that ineffective communication, cognitive vulnerability, work-family interaction, financial conflict and lack of participation in home affairs, were the most common causes of marital conflict; so it is recommended that preventive and educational programs for couples include the abovementioned factors.
Effect of NPK Fertilizer on Nutrient Uptake, Growth, Yield and Beta-carotene of Cutleaf Groundcherry (Physalis angulata L.) of Genotypes
Authors: Yamika W.S.D. , Simbolon G.P. , Waluyo B. , Aini N. 
Published: July 2021

Background: Cutleaf groundcherry (Physalis angulata L.) has vitamins that are good for health. There were several genotypes of cutleaf groundcherry that have the potential to be widely cultivation, but information of doses of NPK fertilizer for those genotypes was still limited. The objective of this experiment was to determine the response of cutleaf groundcherry to different rates of NPK fertilizer. Methods: The experiment was conducted May - September 2019 in dry land field. The experiment used a factorial randomized block design with three replications. The first factor was genotypes cutleaf groundcherry (PA 01, PA 02 and PA 03) and the second factor was doses of NPK fertilizer (75, 150 and 225 kg ha-1 NPK). Conclusion: The increased in doses of NPK fertilizer to 225 kg ha-1 NPK increased nutrient uptake, plant growth and fresh fruit weight for each genotype of cutleaf groundcherry. Meanwhile ascorbic acid content increased with a dose of 150 kg ha-1 NPK, but decreased with increased NPK fertilizer rates. The beta-carotene content with 75 kg ha-1 NPK fertilizer was higher than with 150 and 225 kg ha-1 doses. The increase of NPK fertilizer doses otherwise decreases the beta-carotene content for each genotype. Shoot dry weight, fresh fruits weight and ascorbic acid in PA 03 genotype higher than PA 01 and PA 02 genotypes.
CHARACTERISATION AND STUDY OF 1- [2- (2-BENZOYLPHENOXY) ETHYL] -6-METHYLURACIL MECHANISM OF ACTION
Authors: Jain (Korsakova) E. A. , Demchenko D. V. , Ozerov A. A. , Makarova M. N. , Makarov V. G. , Balabanyan V. Yu. 
Published: July 2021

The aim of the study is to identify 1-[2-(2-benzoylphenoxy) ethyl]-6-methyluracil using various methods of analysis, as well as to study its action mechanism against wild-type and mutant forms of HIV-1 reverse transcriptase (RT).Materials and methods. To characterize the structure of the test substance, a few kinds of analysis (X-ray diffraction, elemental, thermal) as well as a few kinds of spectroscopy (UV, IR, and NMR) have been used. The study of the action mechanism of the compound as a potential drug was carried out by evaluating the inhibitory activity against HIV-1 RT wild-type and its mutant forms corresponding to drug-resistant viral strains.Results. The studies have been carried out to confirm the structure of 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil. The UV spectrum has a pronounced absorption maximum when measuring a solution of the substance in tetrahydrofuran at the concentration of 0.10 mg / ml. In the IR spectrum, there are specific bands in the range of 4000-370 cm–1. These factors make it possible to use UV and IR spectra to identify the test compound in the substance. It has also been established that the number and mutual arrangement of functional groups, the integrated intensity of signals in the 1H-NMR spectrum, as well as the structure of the carbon skeleton, correspond to the structure of 1-[2-(2-benzoylphenoxy) ethyl]-6-methyluracil. The results of studying the action mechanism showed that the test compound is an effective inhibitor of wild-type HIV-1 RT with an inhibition constant of 0.2 µM, as well as an enzyme inhibitor (mutation G190A) with an inhibition constant of 8 µM; enzyme (mutation Y181C) with an inhibition constant of 10 µM, as well as a reverse transcriptase (RT) inhibitor (mutation L100I, K103N, V106A) and a double mutant K103N / Y181C with an inhibition constant of more than 20 µM.Conclusion. As a result of the performed X-ray structural, elemental, 1H-NMR and 13C-NMR analyzes, the structure of 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil has been confirmed. The possibility of using UV, IR and NMR spectroscopy, as well as thermal analyzes to confirm the authenticity during the verification of 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil, has been shown. The developed methods can be used in the quality control and included in the draft of practice guidelines for the investigated substance. The studies of the action mechanism of the compound of HIV-1 RT reverse transcriptase have shown that this compound belongs to the group of non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1.