bluuebunny/crossref_metadata_2025_split huggingface dataset:
JAK2/STAT3 in role of arsenic-induced cell proliferation: a systematic review and meta-analysis
Authors: Ran Shanshan , Ren Qingxin , Li Shugang 
Published: July 2021

Abstract

Objectives
Malignant cell proliferation is one of the important mechanisms of arsenic poisoning. A large number of studies have shown that STAT3 plays an important role in cell malignant proliferation, but there are still many contradictions in the effect of arsenic on JAK2/STAT3. This study aims to explore the role of JAK2/STAT3 in arsenic-induced cell proliferation.

Methods
By taking normal cells as the research object and using Standard Mean Difference (SMD) as the effect size, meta-analysis was used to explore the effect of arsenic on JAK2/STAT3. Then, the dose-effect Meta was used to further clarify the dose-effect relationship of arsenic on JAK2/STAT3.

Results
Through meta-analysis, this study found that arsenic could promote the phosphorylation of STAT3 (SMD=4.21, 95%CI [1.05, 7.37]), and increase IL-6 and p-JAK2, Vimentin, VEGF expression levels, thereby inducing malignant cell proliferation. In addition, this study also found that arsenic exposure dose (<5 μmol m−3), time(<24 h) and cell type were important sources of heterogeneity in the process of exploring the effects of arsenic on p-STAT3, IL-6 and p-JAK2. Dose-effect relationship meta-analysis results showed that arsenic exposure significantly increased the expression level of IL-6. When the arsenic exposure concentration was less than 7 μmol m−3, the expression level of p-JAK2 upregulated significantly as the arsenic exposure concentration gradually increasing. Moreover, the expression level of p-STAT3 elevated significantly with the gradual increase of the arsenic concentration under 5 μmol m−3 of arsenic exposure, but the expression level of p-STAT3 gradually decreases when the concentration is greater than 5 μmol m−3.

Conclusions
Exposure to low dose of arsenic could promote the expression of JAK2/STAT3 and induce the malignant proliferation of cells through upregulating IL-6, and there was dose-effect relationship among them.
Application of micro and porous materials as nano-reactors
Authors: Isola Lawal Adedoyin , Chen Tzu-Chia , Elveny Marischa , Alkaim Ayad F. , Thangavelu Lakshmi , Kianfar Ehsan 
Published: July 2021

Abstract
In general, nanostructured materials with specific size, shape and geometry have unique and different properties from bulk materials. Using reaction media with nanometer and micrometer dimensions, they can produce new nanomaterials with interesting and remarkable properties. In general, nano-reactors are nanometer-sized chambers in which chemical reactions can take place. of course, nanoreactors are somehow part of the reaction, and this is the main difference between them and micro-reactors. One of the useful solutions to achieve the environment of nanoreactors is the use of porous materials, so due to the importance of nanoreactors, porous structures of silicate and zeolite are among the most prominent and widely used compounds in this group.
Insight role of TiO2 to improve the photocatalytic performance of WO3 nanostructures for the efficient degradation of ciprofloxacin
Authors: Tahir Muhammad Bilal , Farman Sohail , Rasheed Adil , Alrobei Hussein , Shahzad Khurram , Ali Arshid Mahmood , Muhammad Shabbir 
Published: July 2021

Abstract
The current research work is to investigate the photocatalytic efficiency and degradation of ciprofloxacin using WO3/TiO2 nanoparticles under visible light irradiation. The nanoparticles of tungsten trioxide (WO3) and its composite with titanium dioxide (TiO2) i.e. WO3/TiO2 was prepared by hydrothermal method. Four basic characterizations were performed to study the prepared sample materials. To study the morphology of the prepared samples, scanning electron microscopy (SEM) was used. The results of SEM clearly showed that tungsten trioxide (WO3) has Rectangular shaped structure. The average size of the pure Tungsten trioxide nanoparticles was about 40–540 nm. The composite of WO3/TiO2 has spherical structure. The reason behind that was the addition of TiO2 in WO3 changes the morphology of pure WO3, and transformed the rectangular structure to a spherical structure. The presence of TiO2 changes the position and orientation of the nanorods in all possible directions. For the detailed analysis of the functional groups present in these samples, band gap, and optical properties of these samples, Fourier transform infrared spectroscopy (FTIR), ultraviolet visible (UV–VIS) spectroscopy and Photoluminescence (PL) emission spectroscopy was used. UV–Vis spectroscopy results showed that the bandgaps of prepared catalysts vary within the range of 2.76 – 2.5 eV. This decrease in bandgap is directly related with the concentration ratio of TiO2 in WO3. The maximum excitation wavelength observed at 440 nm. The maximum degradation efficiency was at 2% of WO3/TiO2 composite catalyst due to unique morphological structure and increase rate of photo absorption.
Impact of Body Mass Index on Survival of Metastatic Renal Cancer
Authors: Salgado Jose Javier , Fernandez-Pello Sergio , Ruger Laura , Gonzalez Ivan , Alonso Laura , Rodriguez-Villamil Luis 
Published: July 2021

Obesity has been established as a risk factor for renal cell carcinoma (RCC). Recently, studies have described obesity as a probable protecting factor in the metastatic stage of RCC. In this study, we assessed the relationship between body mass index (BMI) and overall survival in patients under systemic therapy.The correlation between BMI and overall median survival was studied in 76 patients diagnosed with metastatic RCC under systemic therapy. The groups were divided into overweight and obesity (BMI > 25 kg/m2) and underweight or normal (BMI < 25 kg/m2). Statistical analysis was performed using the Cox regression model adjusted by gender.A total of 76 patients were studied: 16 women (21%) and 60 men (79%). The median BMI was 27.96 kg/m2; 24 patients (31.6%) had low BMI and 52 (68.4%) had high BMI. Median overall survival in the group with BMI > 25 kg/m2 was 17 months (95% confidence interval [CI]: 13–34 months), while in the group with BMI ≤ 25 kg/m2, it was 14 months (95% CI: 8–20 months). When adjusted by gender, the group with BMI > 25 kg/m2 presented a hazards ratio of 0.54 (95% CI: 0.30–0.96), P = 0.044 (Log Rank).A high BMI significantly acts as a protecting factor. We observed an increased overall survival of overweight and obese patients within the context of metastatic RCC under systemic treatment. These data confirm the findings published in other studies that suggest the role of lipid metabolism in this type of tumors.
Chronic patellofemoral instability and pain treated effectively by anteromedial tibial tubercle transfer (Fulkerson osteotomy) with or without medial patellofemoral ligament reconstruction
Authors: Mukhopadhaya John , Gupta Arvind , Sinha Amit K. , Bhadani Janki S. 
Published: July 2021

<p><strong>Background</strong>-Chronic patellar instability (subluxation and dislocation) and pain is a debilitating knee condition that frequently involves young, active patients. Bony malalignment and soft tissue injury (torn or stretched MPFL) is considered as a surgical indication for distal realignment in the form of Anteromedial tibial tubercle transfer(Fulkerson osteotomy) with or without MPFL reconstruction that effectively prevents the patella from tracking laterally and thus unloads the lateral patella while making the patellofemoral joint more congruous , stable and pain free.</p><p><strong>Materials and method</strong> - It is a prospective study of 22 patients of chronic patellar instability and pain. Follow up ranged from 24 to 36(average 30) months. Preoperative assessment included clinical examination, Lysholm, IKDC score and Radiological examination (X-ray, CT scan and MRI). 18 patients with history of dislocation and pain having bony malalignment and torn MPFL were treated with Fulkerson osteotomy and MPFL reconstruction and 4 patients with history of subluxation and pain having bony malalignment only were treated with Fulkerson osteotomy alone. Patients were followed up with the help of X-rays at regular interval and the clinical outcome was measured using scoring system.</p><p><strong> </strong><strong>Results</strong>-There was a significant improvement in postoperative assessment with regards to scoring system (Lysholm and IKDC) and knee pain. Union at osteotomy site for all patients was seen. None of the patients had further episode of dislocation or subluxation. Pain at femoral site of MPFL reconstruction in 2 cases persisted for 3 months followed by resolution of their symptoms. One of our patients had profuse swelling at the site of operation postoperatively which was treated with Rest, Ice Pack, Compression and Limb elevation. Out of 22 patients undertaken infection at osteotomy site was seen in 1 patient for which implant removal was done from osteotomy site after union.</p><p> <strong>Conclusion</strong>-Anteromedial Tibial tuberosity osteotomy and MPFL reconstruction is a successful procedure to treat patellofemoral pain and instability.</p>
Deixis: A Pragmatic Perspective
Authors: D. Saffah Dr. Mariam , Hameed Al-Hindawi Dr. Fareed 
Published: July 2021

It can be said that the relationship between language and context is best manifested through the concept of deixis. It refers to a set of expressions whose interpretation depends on the context in which they appear. The current study tries to present a thorough review of the topic in question from a pragmatic perspective, enhancing its different categories, functions, and shedding some light on its relation to the phenomenon of indexicality. Deixis has not been given its due attention. Thus, this study attempts to bridge this gap in the literature through answering the following questions: What are the categories of deixis? What is the role of context in interpreting deixis? And what is the relation between deixis and indexicality?
Are professional pharmacy services being offered for free in pharmacies? A feasibility study exploring the use of a time motion study in New Zealand
Authors: Abdul Aziz Yasmin , Heydon Susan J. , Duffull Stephen B. , Marra Carlo A. 
Published: July 2021

Background: Pharmacists report to be providing patient-focused clinical services for which they receive no remuneration. Limited literature exists about unfunded services leading to difficulties in ascertaining an appropriate study design for such research.
Objective: This study aims to assess the appropriateness of a proposed study design before launching a nationwide study to investigate the provision of unfunded patient care services.
Methods: A multi-methods approach was utilised consisting of (1) continuous time motion study in community pharmacies (2) semi structured patient interviews (3) patient follow up (4) semi structured interviews with pharmacy owners/managers. All observations of unfunded patient care services were recorded, numerically coded and descriptively analysed. Semi structured interviews were audio recorded and transcribed verbatim. A semantic thematic analysis was carried out. Appropriateness of study design was dictated by the ability to characterise services and obtain patient perceptions.
Results: Ten pharmacies took part in the feasibility study, across the city of Dunedin, New Zealand, representing a range of different practice settings and demographics. Ten patients were interviewed and six responded to follow up. Both pharmacy and patient recruitment proved challenging due to concerns around disruption to workflow and patient privacy. A continuous observation time motion study was found to be appropriate as it minimises disruption to workflow with no additional work required from the pharmacy teams.
Conclusions: A continuous observation time motion study proved to be an appropriate method to investigate the provision of unfunded services on a national scale. The findings of the study suggest design changes such as length of observation time, increasing patient recruitment and additional patient questions to enhance the nationwide study.
¿Cómo ha cambiado la atención a clientes en México durante la contingencia del COVID-19?
Authors: Villafaña Gutiérrez Daniela 
Published: July 2021

La presente investigación cualitativa tiene como objetivo destacar la importancia e implementación de la atención al cliente en las empresas, mismas que este año sufrieron un impacto significativo en sus relaciones comerciales y profesionales causadas por el virus del COVID-19.
Este último ocasiono una contingencia mundial misma que provocó el cierre parcial y total de las empresas locales, nacionales e internacionales en todo el mundo, debido a esto, las organizaciones generaron, innovaron e implementaron estrategias para mantenerse dentro de su mercado de ventas.
CÉLIO IN THE SKY WITH DIAMONDS: HIV/AIDS E MORTE EM UM POEMA DE ANGÉLICA FREITAS
Authors: Noronha da Fonseca Leandro 
Published: July 2021

Para além de seus contornos biomédicos, a questão do HIV/aids marca presença em diversas linguagens artísticas, inclusive na literatura, principalmente nas mais distintas vertentes da prosa. O presente trabalho parte da importância de Tente entender o que tento dizer (Bazar do Tempo, 2018), antologia poética voltada ao HIV/aids, e também da potencialidade de investigação sobre a temática na poesia contemporânea brasileira. A partir de interpretação do poema “Célio no céu, com toda a sorte de pedras preciosas”, da poeta gaúcha Angélica Freitas, consideramos que o tema é trazido a partir de uma realidade das primeiras décadas da epidemia, trando com leveza e sem moralismos temas como a morte e e o sexo.
Palavras-chave: HIV/aids. Angélica Freitas. Poesia contemporânea brasileira.
VALORES DE MUNDO E VALORES LITERÁRIOS NA POESIA BRASILEIRA CONTEMPORÂNEA
Authors: Moreira Campos Bruna Ingryd 
Published: July 2021

Este artigo procura discorrer acerca dos valores literários e valores de mundo, noções delimitadas por Bakhtin, na literatura brasileira contemporânea, embasando-se no contraste que há entre ambos, construindo uma análise do impacto do tempo histórico e do espaço social na poesia brasileira contemporânea, perspectiva notadamente cronotópica. Para tanto, observamos poemas de meu nome agora é uma cidade devastada (2020), de Ithalo Furtado e Lutar é crime (2019), de Bell Puã. Nos poemas analisados, o tempo e o espaço estão diretamente ligados com a essência humana de seu eu lírico e não podem ser vistos apenas como pano de fundo para o processo de criação dos poetas, mas como determinantes para o resultado formal e temático dos poemas.

Palavras-chave: Poesia contemporânea. Valores de mundo. Valores literários. Cronotopo.
A CONSTRUÇÃO DO ETHOS EM MARÍLIA DE DIRCEU DE TOMÁS ANTÔNIO GONZAGA
Authors: Ribeiro Rodrigues Jaciel , Kelly Pereira de Holanda Layana 
Published: July 2021

O presente artigo propõe-se a destacar a construção de ethos da personagem Dirceu, na obra Marília de Dirceu de Tomás Antônio Gonzaga. Para isso, a pesquisa sustenta-se na Análise do Discurso Francesa, especificamente na teoria de Maingueneau (2008). A pesquisa parte da problemática: Como se apresenta a construção do ethos de Dirceu na obra Marília de Dirceu? Analisou-se, a Lira I da parte I, como forma de recorte da pesquisa. A Lira tem como temática: provar por meio de suas posses e do seu caráter que Dirceu é um homem honrando e respeitado por todos, ganhando a confiança de seu destinatário, no caso Marília. O eu-lírico constrói uma imagem de si exemplar, em um discurso que inspira confiança, enfatizando sua humildade, simplicidade e o amor verdadeiro. A metodologia partiu de uma pesquisa bibliográfica, interpretativa e analítica, de cunho qualitativo, tendo como base os teóricos, além do mencionado acima, Amossy (2008) e Eggs (2008), entre outros. Observou-se que a Lira I da parte I, corresponde-se a elementos de corporalidade que implica no modo de atuação no espaço social do sujeito.

Palavras-chave: Discurso. Construção de ethos. Marília de Dirceu. Tomás Antônio Gonzaga.
TEATRO E IDENTIDADE NEGRA: AS NUANCES DA REPRESENTAÇÃO IDENTITÁRIA EM DESFUGA, DE UBIRAJARA FIDALGO
Authors: De Sousa Elizeu Arruda , Levy Marques Rosário Ykaro 
Published: July 2021

O artigo, aqui em tela, firma-se no objetivo de examinar as diferentes formas como a representação da identidade negra é encarada pela personagem protagonista do monólogo teatral Desfuga, do dramaturgo caxiense/ maranhense Ubirajara Fidalgo. A peça escrita e encenada, inicialmente, na década de 1980, traz um percurso conflituoso de rejeição e aceitação da identidade afrodescendente pelo protagonista do texto dramático. Tal trajetória acaba por se identificar com tantas outras trilhadas por negros do Brasil dos anos 80- século XX- e até mesmo os da atualidade. Ubirajara Fidalgo utiliza o teatro, em tom de denúncia, como um instrumento de resistência ao racismo estrutural que ainda hoje é muito verificado. Informando sobre o procedimentos metodológicos que alicerçaram o presente estudo, realizou-se uma pesquisa bibliográfica voltada para teóricos que focalizam, em suas pesquisas, conceitos acerca da representação e identidade negra, tais como: Augel (2010), Bispo (2011), Hall (1997,2003, 2005), Santos (2015), Sousa (2018). Uma outra vertente de abordagem diz respeito às informações sobre a biografia e produção teatral de Ubirajara Fidalgo, fundamentadas por autores como: Fidalgo (2017), Freitas (2013), Rezende (2017), Santos (2014). Também é procedida a leitura e análise da peça teatral Desfuga, destacando-se e examinando-se os trechos em que são verificáveis as alternantes formas como o protagonista se relaciona com a identidade negra.
PALAVRAS-CHAVE: Identidade negra. Resistência. Teatro.
Nietzsche y el problema del arte en “El origen de la tragedia”
Authors: Guauque Socha Laura Indira 
Published: July 2021

El artículo es un intento de lectura de la primera obra de Nietzsche: El origen de la tragedia. La orientación del problema de investigación se dirige a la pregunta sobre los principales conceptos que desarrolla Nietzsche en esta obra en torno al arte. Nietzsche presenta en su análisis sobre los orígenes de la tragedia una interpretación del arte y de la verdad radicalmente distanciada de la visión occidental de los mismos fenómenos. Nietzsche propone en El origen de la tragedia una estética de la existencia relacionada con el pensamiento trágico, lo trágico como fenómeno estético y la consolidación a partir de este de una diferente valoración de la vida. No obstante, el desarrollo de dicha idea en toda su complejidad escapa al proceso de creación de esta primera obra. El problema de lo trágico ha de evolucionar en Nietzsche junto con el desarrollo posterior de toda su obra filosófica, sin embargo, las ideas esbozadas en este “libro imposible” constituyen ya el presentimiento de las grandes líneas de su pensamiento.
El origen de los sistemas normativos. Una propuesta desde la moral evolucionista
Authors: Sepúlveda Camilo Andrés 
Published: July 2021

Nadie puede poner en duda que entre las características del ser humano se encuentra su naturaleza moral, y, muy probablemente, los sistemas normativos que el hombre en sociedad establece son el resultado de ella, sin embargo, no hay suficiente claridad acerca de cómo desarrollamos dicha naturaleza como especie humana. Una respuesta de tipo evolucionista sugeriría que si hay un rasgo característico distintivo en nosotros como especie debió ser el resultado de adaptaciones al medio en la lucha por sobrevivir. El objetivo de este artículo es revisar dos propuestas de este tipo, la de Ernst Tugendhat, según la cual los sistemas normativos son producto del desarrollo del lenguaje proposicional, y la de Richard Dawkins y su concepto de memes. Palabras clave: Evolucionismo moral, Lenguaje proposicional, Memes, Sistemas normativos.
Constructivismo y teoría de la historia
Authors: Londoño Carlos Arturo 
Published: July 2021

En su filosofía, Hegel considera que la finalidad de la historia es la conquista de la libertad en consonancia con el derecho racional universal y el desarrollo de la cultura intelectual (el espíritu). El progreso en el espíritu es generado por la toma conciencia de sí y por los principios éticos que se universalizan, así como también se realiza (se extraña) objetivamente como institución jurídica y a través de la nación. A diferencia de este idealismo histórico hegeliano, Marx sustenta el materialismo histórico para el cual las estructuras político-jurídicas y de la conciencia social están condicionadas “en última instancia” por la estructura socioeconómica. Habermas, por último, intenta reconstruir el materialismo histórico apoyándose en el aprendizaje intelectivo y construido del conocimiento, la moral y la comunicación, siguiendo especialmente a Piaget y a Kohlberg. Esta reconstrucción de la teoría de la historia significa un “retorno” a la filosofía hegeliana, pero a un nuevo nivel, pues se apoya en las ciencias reconstructivas del aprendizaje inteligente.
Presentacion
Authors: Bolivar Simon 
Published: July 2021

Llegar a la edición número 10 de una revista de filosofía no deja de ser un acontecimiento inusitado, sobre todo en una época en que la sociedad de consumo tiende a acabar no sólo con la libertad de las personas sino con su misma cultura, toda vez que el nihilismo y la pérdida del sentido se van apoderando de casi todos los individuos, aún de quienes de una u otra forma están en permanente contacto con la dimensión cultural y simbólica del mundo actual.
Traducción del francés: Lanbry B. Hobbes
Authors: Mora Bautista Luis Augusto 
Published: July 2021

Capitulo II: El medio científico La deducción en los escolásticos. _La filosofía inglesa en el siglo XVI: Lord Herbert Cherbury, Cudworth. _Las conquistas científicas al comienzo del siglo XVII: Harvey, Galileo. _La nueva concepción del movimiento. _El principio de inercia. _La filosofía de Francisco Bacon de Verulamio.
Los valores y la responsabilidad en las prácticas educativas
Authors: Duarte Cuadros Rubén Alberto 
Published: July 2021

Es necesario reflexionar en torno al lugar que ocupan los valores éticos y ciudadanos, en especial, la responsabilidad en las prácticas educativas Es oportuno señalar que se hace indispensable aclarar el sentido y el contenido de lo que podemos entender por valores en su contexto social. En la educación en valores no puede reducirse a teorías sino que se encuentra ligado a prácticas institucionales y hace parte constitutiva de la evaluación institucional. Palabras clave: ética, valores, evaluación institucional.