bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential survival benefits of open over laparoscopic radical gastrectomy for gastric cancer patients beyond three years after surgery: result from multicenter in-depth analysis based on propensity matching
Authors: Huang Ze-Ning , Ma YuBin , Chen Qi-Yue , Zheng Chao-Hui , Li Ping , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Lu Jun , Cao Long-Long , Lin Mi , Tu Ru-Hong , Lin Ju-Li , Zheng Hua-Long , Huang Chang-Ming 
Published: June 2021

Abstract
Background
The oncologic efficacy of laparoscopic versus open surgery for advanced distal gastric cancer (ADGC) beyond 3 years after surgery remain obscure.

Methods
A total of 1256 patients with ADGC at two teaching institutions in China from April 2007 to December 2014 were enrolled. The general data of the two groups were identified to enable rigorous estimation of propensity scores. Restricted mean survival time (RMST) and Landmark analysis was used to compare survival.

Results
After matching 461 patients each in the open distal gastrectomy (ODG) and laparoscopic distal gastrectomy (LDG) groups, they were included into analysis. The 3- and 5-year overall survival (OS) and disease-free survival were comparable in two groups. RMST-stratified analysis showed that the 3-year RMST of ODG group was similar to that of LDG group in patients with cT4a (− 1.38 years, p = 0.163) or with cT4a and tumor size > 5 cm, whereas the 5-year RMST had significant differences between groups in cT4a patients(− 8.36 years, P = 0.005) or cT4a and tumor size > 5 cm patients(4.67 years, P = 0.042). In patients with cT4a and tumors > 5 cm, the number of peritoneal recurrences was significantly fewer in the ODG group than in the LDG group (4 vs. 17, P = 0.033), and the peritoneal recurrence time and multiple-site recurrence time were both later in the ODG group.

Conclusion
By reducing recurrence, ODG achieves a better survival for GC patients with serous infiltration and tumors larger than 5 cm beyond 3 years after surgery. The present findings can serve as a reference for surgical options and the setting of follow-up time point for clinical studies.
Molecular targets for antifungals in amino acid and protein biosynthetic pathways
Authors: Kuplińska Aleksandra , Rząd Kamila 
Published: June 2021

AbstractFungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems caused by fungal pathogens. There is a growing need for improvement of the availability of antifungal drugs, decreasing their prices and reducing side effects. Searching for novel approaches in this respect, amino acid and protein biosynthesis pathways appear to be competitive. The route that leads from amino acid biosynthesis to protein folding and its activation is rich in enzymes that are descriptive of fungi. Blocking the action of those enzymes often leads to avirulence or growth inhibition. In this review, we want to trace the principal processes of fungi vitality. We present the data of genes encoding enzymes involved in amino acid and protein biosynthesis, potential molecular targets in antifungal chemotherapy, and describe the impact of inhibitors on fungal organisms.
Performance of a SARS CoV-2 antibody ELISA based on simultaneous measurement of antibodies against the viral nucleoprotein and receptor-binding domain
Authors: Reiners Nina , Schnurra Carolin , Trawinski Henning , Kannenberg Judith , Hermsdorf Thomas , Aebischer Andrea , Schöneberg Torsten , Reiche Sven , Jassoy Christian 
Published: June 2021

AbstractSARS CoV-2 antibody assays measure antibodies against the viral nucleoprotein (NP) or spike protein. The study examined if testing of antibodies against both antigens increases the diagnostic sensitivity. Sera (N=98) from infected individuals were tested with ELISAs based on the NP, receptor-binding domain (RBD), or both proteins. The AUROCs were 0.958 (NP), 0.991 (RBD), and 0.992 (NP/RBD). The RBD- and NP/RBD-based ELISAs showed better performance than the NP-based assay. Simultaneous testing for antibodies against NP and RBD increased the number of true and false positives. If maximum diagnostic sensitivity is required, the NP/RBD-based ELISA is preferable. Otherwise, the RBD-based ELISA is sufficient.
Fat-enlarged axillary lymph nodes are associated with node-positive breast cancer in obese patients
Authors: diFlorio-Alexander Roberta M. , Song Qingyuan , Dwan Dennis , Austin-Strohbehn Judith A. , Muller Kristen E. , Kinlaw William B. , MacKenzie Todd A. , Karagas Margaret R. , Hassanpour Saeed 
Published: June 2021

Abstract
Purpose
Obesity associated fat infiltration of organ systems is accompanied by organ dysfunction and poor cancer outcomes. Obese women demonstrate variable degrees of fat infiltration of axillary lymph nodes (LNs), and they are at increased risk for node-positive breast cancer. However, the relationship between enlarged axillary nodes and axillary metastases has not been investigated. The purpose of this study is to evaluate the association between axillary metastases and fat-enlarged axillary nodes visualized on mammograms and breast MRI in obese women with a diagnosis of invasive breast cancer.

Methods
This retrospective case–control study included 431 patients with histologically confirmed invasive breast cancer. The primary analysis of this study included 306 patients with pre-treatment and pre-operative breast MRI and body mass index (BMI) > 30 (201 node-positive cases and 105 randomly selected node-negative controls) diagnosed with invasive breast cancer between April 1, 2011, and March 1, 2020. The largest visible LN was measured in the axilla contralateral to the known breast cancer on breast MRI. Multivariate logistic regression models were used to assess the association between node-positive status and LN size adjusting for age, BMI, tumor size, tumor grade, tumor subtype, and lymphovascular invasion.

Results
A strong likelihood of node-positive breast cancer was observed among obese women with fat-expanded lymph nodes (adjusted OR for the 4th vs. 1st quartile for contralateral LN size on MRI: 9.70; 95% CI 4.26, 23.50; p < 0.001). The receiver operating characteristic curve for size of fat-enlarged nodes in the contralateral axilla identified on breast MRI had an area under the curve of 0.72 for predicting axillary metastasis, and this increased to 0.77 when combined with patient and tumor characteristics.

Conclusion
Fat expansion of axillary lymph nodes was associated with a high likelihood of axillary metastases in obese women with invasive breast cancer independent of BMI and tumor characteristics.
On the Optimal Adhesion Control of a Vortex Climbing Robot
Authors: Papadimitriou Andreas , Andrikopoulos George , Nikolakopoulos George 
Published: June 2021

AbstractThis article tackles the challenge of negative pressure adhesion control of a Vortex Robotic (VR) platform, which utilizes a modified Electric Ducted Fan (EDF)-based design for successfully adhering to surfaces of variable curvature. The resulting Vortex Actuation (VA) system is estimated through a switching Autoregressive-Moving-Average with eXternal input (ARMAX) identification, for accurately capturing the throttle to adhesion force relationship throughout its operating range. For safe attachment of the robot on a surface, the critical adhesion is modeled based on the geometrical properties of the robotic platform for providing the required reference forces. Within this work, an explicit controller via the use of a Constraint Finite Time Optimal Control (CFTOC) approach is designed in an offline manner, which results in a lookup table realization that ensures overall system stability in all state transitions. In an effort to further improve the tracking response for arbitrary setup orientations, the adhesion control scheme is extended through a switching EMPC framework. The resulting frameworks are tested through both dynamic simulation and experimental sequences involving: a) adhesion control on a rotating test curved surface and, b) adhesion and locomotion sequences on a water pipe.
The value of domiciliary medication reviews: a thematic analysis of patient views
Authors: McCormick Patricia , Coleman Bridget , Bates Ian 
Published: June 2021

AbstractBackground Medication reviews are recognised as essential to tackling problematic polypharmacy. Domiciliary medication reviews (DMRs) have become more prevalent in recent years. They are proclaimed as being patient-centric but published literature mainly focuses on clinical outcomes. However, it is not known where the value of DMRs lies for patients who participate in them. Objective To determine the value of domiciliary medication reviews to service users. Setting Interviews took place with recipients of domiciliary medication reviews residing in the London boroughs of Islington and Haringey. Method Semi-structured interviews analysed using thematic analysis. Main outcome measure Themes and sub-themes identified from interview transcripts. Results Five themes were identified: advantages over traditional settings, attributes of the professional, adherence, levels of engagement and knowledge. Conclusion For many patients, the domiciliary setting is preferred to traditional healthcare settings. Patients appreciated the time spent with them during a DMR and felt listened to. Informal carers felt reassured that the individual medication needs of their relative had been reviewed by an expert.
What is public health? public goods, publicized goods, and the conversion problem
Authors: Anomaly Jonathan 
Published: June 2021

AbstractPublic health programs began as an attempt to fight infectious diseases that are difficult to address without collective action. But the concept and practice of public health has ballooned to encompass an expanding list of controversial public policy goals ranging from reducing obesity to raising self-esteem. As the list of controversial goals expands, support for “public health” measures contracts. I’ll briefly defend the view that we should define public health as the provision of health-related public goods. I’ll then show that being a health-related public good is not a sufficient condition for counting as a public health goal, since virtually any private good can be converted into a public good by government fiat. This is the conversion problem, which challenges the way we ordinarily think about public goods and public health.
The patient-side surgeon plays a key role in facilitating robot-assisted intracorporeal ileal conduit urinary diversion in men
Authors: Sasaki Yutaro , Takahashi Masayuki , Fukuta Kyotaro , Shiozaki Keito , Daizumoto Kei , Ozaki Keisuke , Ueno Yoshiteru , Tsuda Megumi , Kusuhara Yoshito , Fukawa Tomoya , Yamamoto Yasuyo , Yamaguchi Kunihisa , Izaki Hirofumi , Kanda Kazuya , Kanayama Hiroomi 
Published: June 2021

AbstractThe influence of the console surgeon on the feasibility and outcome of various robot-assisted surgeries has been evaluated. These variables may be partially affected by the skills of the patient-side surgeon (PSS), but this has not been evaluated using objective data. This study aimed to describe the surgical techniques of the PSS in robot-assisted radical cystectomy (RARC) and intracorporeal ileal conduit (ICIC) urinary diversion and objectively examine the changes in surgical outcomes with increasing PSS experience. During a 3-year period, 28 men underwent RARC and ICIC urinary diversion. Clinical characteristics and surgical outcomes were compared between patients who underwent surgery early (first half group) or late in the study period (second half group). The pre-docking incision enabled easy specimen removal. The glove port technique widened the working space of the PSS. The stay suture allowed the PSS to control the distal portion of the conduit, facilitating the passage of the ureteral stents. During stoma creation, pneumoperitoneum pressure was lost by opening the abdominal cavity. To overcome this problem, the robotic arm was used to lift the abdominal wall to maintain the surgical field and facilitate the PSS procedure. Compared with the first half group, the second half group had significantly shorter times for urinary diversion (202 min vs 148 min, p < 0.001), ileal isolation and anastomosis (73 min vs 45 min, p < 0.001), and stenting (23.0 min vs 6.5 min, p < 0.001). As the experience of the PSS increased, the time of the PSS procedures decreased.
“Quiet is the New Loud”: The Biosociology Debate’s Absent Voices
Authors: Ariansen Anja Maria Steinsland 
Published: June 2021

AbstractIn 2000, a controversial article about hormones and gender roles was published to stimulate debate about whether and how biological knowledge should be integrated in sociological research. Two decades later, this so-called biosociology debate is more relevant than ever, as biological knowledge has become widespread across societies and scientific disciplines. Hence, we as sociologists are regularly confronted with biological explanations that challenge our own explanations. Whether this happens in the scientific arena, the classroom, media, or even at social events, these situations often force us, individually, to take a stance on whether to meet such explanations with dialogue or opposition. One could therefore expect that sociologists have an interest in discussing these issues with their peers, but their lack of participation in the biosociology debate suggests otherwise. This paper explores possible reasons for this absence and how sociologists’ views on biosociology are influenced by key agents – sociological associations and journals. Smith’s “A Sacred project of American Sociology”, and Scott’s “A Sociology of Nothing” served as theoretical tools in the paper. A qualitative content analysis of presidential addresses of four sociological associations was conducted. The analyses suggest that sociologist avoid biosociology for widely different reasons, including fear that biosociology legitimizes oppression. This avoidance is probably reinforced by the leftish politization of the sociological discipline and the rightish politization of society. Overcoming obstacles to engagement in biosociology is required to safeguard the scientific integrity of sociology and enable sociologists to provide relevant contributions to research on the Covid-19 pandemic and climate change.
3D Clinorotation Affects Drug Sensitivity of Human Ovarian Cancer Cells
Authors: Przystupski Dawid , Górska Agata , Szewczyk Anna , Drąg-Zalesińska Małgorzata , Kulbacka Julita 
Published: June 2021

AbstractNumerous studies have reported that gravity alteration displays a remarkable influence on the biological processes of cancer cells. Therefore, gravity-related experiments have become a promising method of improving knowledge in the field of cancer biology and may be useful to detect remarkable implications for future cancer treatment. Taking this concept further, we used a 3D clinostat (3D-C; 10 rpm of changing direction) to analyse the effect of short-term exposure to simulated microgravity (sμg) on cisplatin sensitivity of drug resistant human ovarian cancer cells SKOV-3. This allowed us to investigate whether altered gravity affects drug susceptibility of cancer cells. Our studies revealed that sμg exposure affects SKOV-3 cells morphology and drug efficiency. We observed the altered cell shape, the presence of membrane blebbing and lamellipodia as well as the lack of filopodia when the cells had been cultured on 3D-C for 2 h. Cytotoxicity, cell death and cell cycle assays showed an increased percentage of apoptotic cells and G0/G1 cell cycle arrest after exposure on the 3D-C with cisplatin in comparison to the static control, non clinorotated cells. Cell proliferation and migration were altered after the exposure to sμg as well. Our studies suggest that the altered gravity conditions affected cellular mechanisms involved in cisplatin resistance, resulting in higher sensitivity of cancer cells to the chemotherapeutic. The investigation and clarification of these results may be a crucial step toward improving our understanding of the relationship between cellular resistance to chemotherapy and the response to altered gravitational conditions.
Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project
Authors: Goode Emma-Jane , Thomas Eirian , Landeg Owen , Duarte-Davidson Raquel , Hall Lisbeth , Roelofs Jolanda , Schulpen Sjors , De Bruin Arnout , Wigenstam Elisabeth , Liljedahl Birgitta , Waleij Annica , Simonsson Louise , Göransson Nyberg Ann 
Published: June 2021

AbstractEvery year, numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment. The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount. However, collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge. This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents, primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies. An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely, considering the impact of a disaster on the environment and public health in the short, medium, and long terms. The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible. This methodology will aid defensible decision making, communication, planning, and risk management, and presents a harmonized understanding of the associated impacts of an environmental emergency.
Disseminated and Relapsing Cryptococcosis: What We Still Have to Learn—a Case Series and Review of Literature
Authors: Botta Annarita , Piccica Matteo , Lagi Filippo , Borchi Beatrice , Zammarchi Lorenzo , Sterrantino Gaetana , Bartoloni Alessandro 
Published: June 2021

AbstractTwo cases of disseminated cryptococcosis are described. The first was an HIV-infected patient where cryptococcosis was diagnosed as “unmasking immune reconstitution syndrome”; the second was an immunosuppressed patient with multiple myeloma. In both cases, a definitive healing could not be reached despite long therapeutic approaches. This review summarizes both the most recent and relevant studies about disseminated and refractory form of cryptococcal infections and identifies research gaps. Given the limited data, we draw some conclusions with respect to management from literature: not clear and accepted indication are available regarding disseminated cryptococcosis, no specific schemes were identified, and the duration of therapy is usually decided case by case and supported only by case reports. In this perspective, usually standard therapeutic schemes and duration of induction depend on multiple factors (e.g., neurologic deficit, non-HIV/non transplant status, CSF culture positivity at 2 weeks, etc.). We found that there are no empiric and literature data that support a role of cryptococcal serum antigen (CRAG) in guiding the antifungal therapy; with the data collected, we think that although is possible, it is very rare to find disseminated cryptococcosis with negative CRAG. We looked also for the more important risk factor of recurrence. Some possible causes explored are risk of azole resistant strains, pre-existent conditions of patients that play a permissive role and the common situation where flucytosine is unavailable that led to suboptimal induction phase of therapy. Herein, we discuss disseminated cryptococcosis with a particular attention to antifungal therapy, role of cryptococcal antigen, and risk factors for recurrence of disease.
The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy
Authors: Punjani Nahid , Bernie Helen , Salter Carolyn , Flores Jose , Benfante Nicole , Mulhall John P. 
Published: June 2021

Abstract

Introduction
Testosterone therapy (TTH) for testosterone deficiency (TD) may lead to elevated estradiol (E2) levels requiring management to avoid unnecessary adverse effects.

Aim
To examine the impact of aromatase inhibitors, specifically anastrozole (AZ), in men with elevated E2 on TTH.

Methods
All patients on TTH at a high volume sexual medicine practice between 2005 and 2019 were reviewed. Men with E2 levels &gt;60 pg/mL regardless of symptoms or 40–60 pg/mL with subjective symptoms were started on AZ 0.5 mg 3x/week. Routine hormone profile and symptom assessment were completed to ensure symptom resolution, reduction of E2 levels and maintenance of testosterone levels. Multivariable logistic regression was completed to determine predictors of men more likely to respond to therapy.

Main Outcome Measure
Demographic and hormonal profiles of men on AZ and predictors of response to therapy.

Results
1708 men with TD were placed on TTH. Of these, 51 (3%) were treated with AZ (AZ+). After exclusions, 44 (2.6%) had elevated estradiol levels &gt;60 pg/mL or &gt;40 pg/mL with symptoms. Demographics were similar between groups. TTH distribution between groups was different with greater rates of topical TTH in the AZ- groups (AZ+:34.1% vs AZ-:53.5%) and greater rates of intramuscular TTH in the AZ+ group (AZ+:38.6% vs AZ-:18.5%) (P = .017 overall). Of the 44 men treated with AZ, 68.0% had pre-AZ E2 levels ≥60 pg/mL and 32.0% had levels between 40 and 60 pg/mL. Median pre-AZ E2 levels were 65 (interquartile range [IQR], 55–94) pg/mL in comparison to 22 (IQR 15–38) pg/mL post-AZ E2 levels (P &lt; .001). Total testosterone levels were similar before and after AZ use (616 (IQR 548–846) ng/dL and 596 (IQR 419–798) ng/dL, respectively, P = .926). No statistically significant predictive factors of E2 reduction using AZ were found.

Conclusion
While no statistically significant predictors for E2 recovery in men on AZ were found, AZ remains a reasonable option for E2 reduction in men with elevated levels on TTH.
Punjani N, Bernie H, Salter C, et al. The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy. Sex Med 2021;9:100378.
Sonority projection effect in French: A signal detection theory approach
Authors: Basirat Anahita , Patin Cédric , Jozefowiez Jérémie 
Published: June 2021

AbstractFocusing on the Sonority Sequencing Principle (SSP), we investigated the extent to which adult native speakers of French are sensitive to sonority-related constraints compared to lexical attestedness. In a non-word acceptability task, participants were asked to rate the acceptability of three types of non-words using a 6-point scale: non-words with attested sonority rising onset, non-words with unattested sonority rising onset, and non-words with unattested sonority falling onset. Data analysis was done using the signal detection theory approach to measure sensitivity of participants to lexical attestedness and to phonological well-formedness (i.e., respecting or violating the SSP). The results showed that speakers distinguished well-formed and ill-formed forms even when lexical attestedness was controlled for. This is consistent with previous findings on sonority projection effects. Participants were more sensitive to lexical attestedness than phonological well-formedness. Future research using computational models should investigate mechanisms that could account for these findings, namely whether a similar result would be obtained without including any assumption about the SSP in these models.