bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tackling random fields non-linearities with unsupervised clustering of polynomial chaos expansion in latent space: application to global sensitivity analysis of river flooding
Authors: El Garroussi Siham , Ricci Sophie , De Lozzo Matthias , Goutal Nicole , Lucor Didier 
Published: August 2021

AbstractA surrogate model is developed to accurately approximate a two-dimensional hydrodynamics numerical solver in order to conduct a reduced-cost variance-based global sensitivity analysis of the hydraulic state. The impact of uncertainties in river bottom friction and boundary conditions on the simulated water depth is analyzed for quasi-unsteady flows. An autoencoder technique adapted to non-linear variable dimension reduction is used to reduce the multi-dimensional model output so that the formulation of the surrogate remains computationally parsimonious. In addition, following the divide-and-conquer principle, a mixture of local polynomial chaos expansions is proposed to deal with non-linearity in the hydraulic state with respect to uncertain inputs. Machine learning techniques are used to automatically partition the input space into clusters that are not affected by non-linearities and support accurate surrogates. This combined strategy is applied to a reach of the Garonne River where river and floodplains dynamics are simulated by the numerical solver Telemac-2D. The merits of this strategy are highlighted when the flood front reaches regions where the topography features a strong gradient and where, consequently, strong non-linearities occur between the water depth and friction as well as hydrologic input forcing. By applying this strategy, the $$Q_2$$

Q
2

metric improves by 90% compared to a classical polynomial chaos expansion surrogate, resulting in a much more reliable sensitivity analysis. This is particularly important in floodplain areas where human and economic activities are at stake.
Serial assessment of inflammatory parameters for prediction of septic complications following surgery for colorectal endometriosis
Authors: Montanari Eliana , Reh Lena Maria , Dauser Bernhard , Birsan Tudor , Hudelist Gernot 
Published: August 2021

SummaryPurposeTo assess whether C‑reactive protein (CRP), white blood cell count (WBC) and body temperature changes are suitable parameters for the early detection of septic complications following resection of colorectal deep endometriosis (DE).MethodsRetrospective data analysis of CRP, WBC and body temperature courses following colorectal surgery for DE at a tertiary referral center for endometriosis.ResultsOut of 183 surgeries performed, 10 major surgical complications were observed, including 4 anastomotic leakages (AL 2%) and 2 rectovaginal fistulae (RVF 1%). In the presence of a lower gastrointestinal tract (GIT)-related septic complication or abdominal wall abscess, serum CRP levels were increased starting at postoperative day 2–3. A cut-off value of 10 mg/dl on day 4 for prediction of early septic complications could be verified (area under the curve 0.94, obtained by receiver operating characteristics analysis, sensitivity 88%, specificity 90%, positive predictive value 32%, negative predictive value 99%). Additionally, most patients with early septic complications exhibited increased WBC levels starting mainly from day 3–4; however, increased inflammatory parameters could not be observed in one patient with an RVF. Body temperature did not prove useful for early discrimination between uncomplicated cases and those with early septic complications.ConclusionRelevant elevations of serum CRP and WBC levels were demonstrated in patients with early septic complications following surgery for colorectal DE starting at postoperative day 2–4. The cut-off value of 10 mg/dl for CRP levels may serve as an early predictor for lower GIT-related septic complications but should be used with caution in women with suspected RVF development.
Evaluating the accuracy of facial expressions as emotion indicators across contexts in dogs
Authors: Bremhorst A. , Mills D. S. , Würbel H. , Riemer S. 
Published: August 2021

AbstractFacial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System (DogFACS) to identify facial expressions in dogs associated with conditions presumably eliciting positive anticipation (expectation of a food reward) and frustration (prevention of access to the food). Our first aim here was to identify facial expressions of positive anticipation and frustration in dogs that are context-independent (and thus have potential as emotion indicators) and to distinguish them from expressions that are reward-specific (and thus might relate to a motivational state associated with the expected reward). Therefore, we tested a new sample of 28 dogs with a similar set-up designed to induce positive anticipation (positive condition) and frustration (negative condition) in two reward contexts: food and toys. The previous results were replicated: Ears adductor was associated with the positive condition and Ears flattener, Blink, Lips part, Jaw drop, and Nose lick with the negative condition. Four additional facial actions were also more common in the negative condition. All actions except the Upper lip raiser were independent of reward type. Our second aim was to assess basic measures of diagnostic accuracy for the potential emotion indicators. Ears flattener and Ears downward had relatively high sensitivity but low specificity, whereas the opposite was the case for the other negative correlates. Ears adductor had excellent specificity but low sensitivity. If the identified facial expressions were to be used individually as diagnostic indicators, none would allow consistent correct classifications of the associated emotion. Diagnostic accuracy measures are an essential feature for validity assessments of potential indicators of animal emotion.
Evidence-based art in the hospital
Authors: Fudickar Axel , Konetzka Dag , Nielsen Stine Maria Louring , Hathorn Kathy 
Published: August 2021

Summary
Background
Evidence-based art is the investigation of art effects and art investigated for effects. In this study the evidence regarding patient preferences for art styles and effects of art in nonpsychiatric hospitals and outpatient departments was reviewed.

Methods
Results from original articles were retrieved by a scoping PubMed search and by browsing the internet using the terms “evidence based art”, “evidence based design”, “art and hospital” and “design and hospital”, “art effect”, “design effect”, “landscape preference” and “abstract art figurative art”. The quality of art was not operationalized as a criterion.

Results
Of the articles 7 original sources showed patient preference for natural scenes and figurative art, 2 studies showed no preference, 16 studies showed positive art effects on well-being and behavior and 5 studies showed a positive effect of nature pictures on measurable findings.

Conclusion
Controversial results together with theoretical aspects suggest natural scenes in patient rooms and diverse art in public areas.
Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage
Authors: Ebrahimi Mohammadhossein , Finnilä Mikko A. J. , Turkiewicz Aleksandra , Englund Martin , Saarakkala Simo , Korhonen Rami K. , Tanska Petri 
Published: August 2021

AbstractOsteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to determine the severity of histopathological cartilage degradation. The results suggest that alterations in the FRPE properties are not evident in the moderate stages of cartilage degradation (OARSI 2-3) as compared with normal tissue (OARSI 0-1). Drastic deterioration of the FRPE properties was observed in severely degraded cartilage (OARSI 4). We also found that the FRPE properties of femoral condyle cartilage related to the collagen network (initial fibril-network modulus) and proteoglycan matrix (non-fibrillar matrix modulus) were greater compared to tibial and patellar cartilage in OA. These findings may inform cartilage tissue-engineering efforts and help to improve the accuracy of cartilage representations in computational knee joint models.
Improved risk estimation of locoregional recurrence, secondary contralateral tumors and distant metastases in early breast cancer: the INFLUENCE 2.0 model
Authors: Völkel Vinzenz , Hueting Tom A. , Draeger Teresa , van Maaren Marissa C. , de Munck Linda , Strobbe Luc J. A. , Sonke Gabe S. , Schmidt Marjanka K. , van Hezewijk Marjan , Groothuis-Oudshoorn Catharina G. M. , Siesling Sabine 
Published: August 2021

Abstract
Purpose
To extend the functionality of the existing INFLUENCE nomogram for locoregional recurrence (LRR) of breast cancer toward the prediction of secondary primary tumors (SP) and distant metastases (DM) using updated follow-up data and the best suitable statistical approaches.

Methods
Data on women diagnosed with non-metastatic invasive breast cancer were derived from the Netherlands Cancer Registry (n = 13,494). To provide flexible time-dependent individual risk predictions for LRR, SP, and DM, three statistical approaches were assessed; a Cox proportional hazard approach (COX), a parametric spline approach (PAR), and a random survival forest (RSF). These approaches were evaluated on their discrimination using the Area Under the Curve (AUC) statistic and on calibration using the Integrated Calibration Index (ICI). To correct for optimism, the performance measures were assessed by drawing 200 bootstrap samples.

Results
Age, tumor grade, pT, pN, multifocality, type of surgery, hormonal receptor status, HER2-status, and adjuvant therapy were included as predictors. While all three approaches showed adequate calibration, the RSF approach offers the best optimism-corrected 5-year AUC for LRR (0.75, 95%CI: 0.74–0.76) and SP (0.67, 95%CI: 0.65–0.68). For the prediction of DM, all three approaches showed equivalent discrimination (5-year AUC: 0.77–0.78), while COX seems to have an advantage concerning calibration (ICI < 0.01). Finally, an online calculator of INFLUENCE 2.0 was created.

Conclusions
INFLUENCE 2.0 is a flexible model to predict time-dependent individual risks of LRR, SP and DM at a 5-year scale; it can support clinical decision-making regarding personalized follow-up strategies for curatively treated non-metastatic breast cancer patients.
Functional recovery after percutaneous revascularization of coronary chronic total occlusions: insights from cardiac magnetic resonance tissue tracking
Authors: Everaars Henk , Schumacher Stefan P. , Stuijfzand Wijnand J. , van Basten Batenburg Martijn , Huynh Jennifer , van Diemen Pepijn A. , Bom Michiel J. , de Winter Ruben W. , van de Ven Peter M. , van Loon Ramon B. , van Rossum Albert C. , Opolski Maksymilian P. , Nap Alexander , Knaapen Paul 
Published: August 2021

AbstractTo evaluate the effect of percutaneous coronary intervention (PCI) of coronary chronic total occlusions (CTOs) on left ventricular (LV) strain assessed using cardiac magnetic resonance (CMR) tissue tracking. In 150 patients with a CTO, longitudinal (LS), radial (RS) and circumferential shortening (CS) were determined using CMR tissue tracking before and 3 months after successful PCI. In patients with impaired LV strain at baseline, global LS (10.9 ± 2.4% vs 11.6 ± 2.8%; P = 0.006), CS (11.3 ± 2.9% vs 12.0 ± 3.5%; P = 0.002) and RS (15.8 ± 4.9% vs 17.4 ± 6.6%; P = 0.001) improved after revascularization of the CTO, albeit to a small, clinically irrelevant, extent. Strain improvement was inversely related to the extent of scar, even after correcting for baseline strain (B =  − 0.05; P = 0.008 for GLS, B =  − 0.06; P = 0.016 for GCS, B =  − 0.13; P = 0.017 for GRS). In the vascular territory of the CTO, dysfunctional segments showed minor improvement in both CS (10.8 [6.9 to 13.3] % vs 11.9 [8.1 to 15.0] %; P < 0.001) and RS (14.2 [8.4 to 18.7] % vs 16.0 [9.9 to 21.8] %; P < 0.001) after PCI. Percutaneous revascularization of CTOs does not lead to a clinically relevant improvement of LV function, even in the subgroup of patients and segments most likely to benefit from revascularization (i.e. LV dysfunction at baseline and no or limited myocardial scar).
Optimal Emission Prices Over the Business Cycles
Authors: Lintunen Jussi , Vilmi Lauri 
Published: August 2021

AbstractWe prove that under the most typical circumstances optimal emission prices are procyclical, i.e., prices should be lower during recessions. The procyclicality is more likely when emissions propagate very slowly into environmental damage. A prime example of such process is$$\hbox {CO}_2$$CO2emissions. We show that carbon prices should be closely linked to the fluctuations of the marginal utility of consumption, which implies relatively modest magnitude of carbon price fluctuations. Our findings imply that climate policies should focus on setting the carbon price to the optimal growth path level and give carbon price fluctuations only a secondary role. Opposite to the carbon price, the cyclicality of optimal emissions depends on the production technology in the energy sector, and may become countercyclical in future if the technology mix becomes less fossil dependent.
Exploring the impact of sustainability (ESG) disclosure on firm value and financial performance (FP) in airline industry: the moderating role of size and age
Authors: Abdi Yaghoub , Li Xiaoni , Càmara-Turull Xavier 
Published: August 2021

AbstractThis study aims at exploring the impact of ESG scores on the value and FP of firms in the airline industry. The potential moderating role of firm size and age has also been studied in an effort to disentangle their relationships in this context. In particular, the analysis involves interaction effects for two types of firms: full-service and low-cost carriers. Based on the collected data from 38 airlines worldwide for the period 2009 to 2019, we observed that contributions to governance initiatives improve a firm’s market-to-book ratio. We also found that a firm’s participation in social and environmental activities is positively and significantly rewarded by a higher level of financial efficiency. Additionally, firm size is the relevant moderator for the association between sustainability disclosure and both firm value and FP in the air transport industry. We therefore propose that a managerial strategy of participating in these initiatives may adapt them based on their total assets as proxy of firm size. In regard to firm age, we did not find it to be a significant moderator.
The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b0,+ (slc3a1/slc7a9)
Authors: Ellingsen Ståle , Narawane Shailesh , Fjose Anders , Verri Tiziano , Rønnestad Ivar 
Published: August 2021

AbstractSystem b0,+ absorbs lysine, arginine, ornithine, and cystine, as well as some (large) neutral amino acids in the mammalian kidney and intestine. It is a heteromeric amino acid transporter made of the heavy subunit SLC3A1/rBAT and the light subunit SLC7A9/b0,+AT. Mutations in these two genes can cause cystinuria in mammals. To extend information on this transport system to teleost fish, we focused on the slc3a1 and slc7a9 genes by performing comparative and phylogenetic sequence analysis, investigating gene conservation during evolution (synteny), and defining early expression patterns during zebrafish (Danio rerio) development. Notably, we found that slc3a1 and slc7a9 are non-duplicated in the zebrafish genome. Whole-mount in situ hybridization detected co-localized expression of slc3a1 and slc7a9 in pronephric ducts at 24 h post-fertilization and in the proximal convoluted tubule at 3 days post-fertilization (dpf). Notably, both the genes showed co-localized expression in epithelial cells in the gut primordium at 3 dpf and in the intestine at 5 dpf (onset of exogenous feeding). Taken together, these results highlight the value of slc3a1 and slc7a9 as markers of zebrafish kidney and intestine development and show promise for establishing new zebrafish tools that can aid in the rapid screening(s) of substrates. Importantly, such studies will help clarify the complex interplay between the absorption of dibasic amino acids, cystine, and (large) neutral amino acids and the effect(s) of such nutrients on organismal growth.
Rapid indicators for monitoring the health of Chlamydomonas nivalis biomass during preservation
Authors: Bemejo-Padilla E. , Kinsou H. , Filali R. , Perez-Bibbins B. , Taidi B. 
Published: August 2021

AbstractMicroalgae are photosynthetic microorganisms that have increasingly attracted interest in the last decade due to their potential for industrial applications. One crucial aspect for the industrial-scale valorisation of algae biomass concerns the quality control during its preservation before being treated to obtain the end-product. Monitoring biomass quality is essential and can be potentially accomplished with the aid of specific biochemical indicators called biomarkers. In this context, the main aim of this work was to identify potential indicators of microalgae biomass viability that could be used as markers of its quality during storage/preservation for commercial operations. The health status of a suspension of Chlamydomonas nivalis was assessed at 4 ºC and 25 ºC during 10 days of storage. The use of the pulse-amplitude-modulation technique, based on chlorophyll fluorescence, was a valuable indicator of the culture viability. The measurement of DNA and of chlorophyll in the supernatant, indicative of cell lysis, also provided satisfactory results; in the case of the DNA, the limit of detection was 3.9 µg DNA·mL−1. The effect of different concentrations of a well-known and cheap preservative, acetic acid, was also evaluated at 4 ºC. This work identified three suitable biomarkers to be used as rapid indicators of the quality of the microalgal suspension prior to its reception for biorefinery activities.
An automated iterative approach for protein structure refinement using pseudocontact shifts
Authors: Cucuzza Stefano , Güntert Peter , Plückthun Andreas , Zerbe Oliver 
Published: August 2021

AbstractNMR structure calculation using NOE-derived distance restraints requires a considerable number of assignments of both backbone and sidechains resonances, often difficult or impossible to get for large or complex proteins. Pseudocontact shifts (PCSs) also play a well-established role in NMR protein structure calculation, usually to augment existing structural, mostly NOE-derived, information. Existing refinement protocols using PCSs usually either require a sizeable number of sidechain assignments or are complemented by other experimental restraints. Here, we present an automated iterative procedure to perform backbone protein structure refinements requiring only a limited amount of backbone amide PCSs. Already known structural features from a starting homology model, in this case modules of repeat proteins, are framed into a scaffold that is subsequently refined by experimental PCSs. The method produces reliable indicators that can be monitored to judge about the performance. We applied it to a system in which sidechain assignments are hardly possible, designed Armadillo repeat proteins (dArmRPs), and we calculated the solution NMR structure of YM4A, a dArmRP containing four sequence-identical internal modules, obtaining high convergence to a single structure. We suggest that this approach is particularly useful when approximate folds are known from other techniques, such as X-ray crystallography, while avoiding inherent artefacts due to, for instance, crystal packing.
Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression
Authors: Zirbes Arrianna , Joseph Jesuchristopher , Lopez Jennifer C. , Sayaman Rosalyn W. , Basam Mudaser , Seewaldt Victoria L. , LaBarge Mark A. 
Published: August 2021

AbstractA majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women more susceptible to cancer initiation. Immune-epithelial cell interactions are important during mammary gland development and the immune system plays an important role in BC progression. The composition of human immune cell populations is known to change in peripheral blood with age and in breast tissue during BC progression. Less is known about changes in immune populations in normal breast tissue and how their interactions with mammary epithelia change with age. We quantified densities of T cells, B cells, and macrophage subsets in pathologically normal breast tissue from 122 different women who ranged in age from 24 to 74 years old. Donor-matched peripheral blood from a subset of 20 donors was analyzed by flow cytometry. Tissue immune cell densities and localizations relative to the epithelium were quantified in situ with machine learning-based image analyses of multiplex immunohistochemistry-stained tissue sections. In situ results were corroborated with flow cytometry analyses of peri-epithelial immune cells from primary breast tissue preparations and transcriptome analyses of public data from bulk tissue reduction mammoplasties. Proportions of immune cell subsets in breast tissue and donor-matched peripheral blood were not correlated. Density (cells/mm2) of T and B lymphocytes in situ decreased with age. T cells and macrophages preferentially localized near or within epithelial bilayers, rather than the intralobular stroma. M2 macrophage density was higher than M1 macrophage density and this difference was due to higher density of M2 in the intralobular stroma. Transcriptional signature analyses suggested age-dependent decline in adaptive immune cell populations and functions and increased innate immune cell activity. T cells and macrophages are so intimately associated with the epithelia that they are embedded within the bilayer, suggesting an important role for immune-epithelial cell interactions. Age-associated decreased T cell density in peri-epithelial regions, and increased M2 macrophage density in intralobular stroma suggests the emergence of a tissue microenvironment that is simultaneously immune-senescent and immunosuppressive with age.
“Blessed are the Nations with High Levels of Schizophrenia”: National Level Schizophrenia Prevalence and Its Relationship with National Levels of Religiosity
Authors: Dutton Edward , Madison Guy 
Published: August 2021

AbstractSchizophrenia is correlated with religious delusions but, heretofore, the relationship between schizophrenia prevalence and religiosity has not been explored at the national level. Examining this relationship, we find that national level schizophrenia prevalence is correlated with national level religiosity and strongly negatively correlated with national level atheism across 125 countries. When controlling for cognitive performance and economic development in multiple regression analyses, the proportion of the variance explained was 2.9% (p < .005) for Religiousness and 5.1% for Atheism (p < .00005). Alternative causal interpretations of this association are discussed.