bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Likuiditas dan Profitabilitas Terhadap Nilai Perusahaan
Authors: Iman Choirul , Sari Fitri Nurfatma , Pujiati Nanik 
Published: November 2021

Abstrak - Terjadinya penurunan laba pada beberapa perusahaan makanan dan minuman pada kuartal I tahun 2019 begitupula pada tahun 2020, kinerja industri mengalami penurunan pada masa penerapan PSBB. Permasalahan yang terjadi di industri tersebut lebih terkait dengan pelemahan dari sisi demand, dimana untuk konsumen kelas menengah atas lebih menahan pengeluaran sementara konsumen menengah bawah sebagai market terbesar tidak memiliki cash untuk berbelanja. Penelitian ini bertujuan untuk menguji pengaruh variabel likuiditas dan profitabilitas terhadap variabel nilai perusahaan. Terdapat dua hipotesis yang diuji dalam penelitian ini. Hipotesis pertama likuiditas berpengaruh positif terhadap nilai perusahaan dan hipotesisis kedua profitabilitas berpengaruh positif terhadap nilai perusahaan. Penelitian ini menggunakan 15 perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia, dipilih menggunakan metode purposive random sampling dari periode tahun 2016 sampai dengan tahun 2020. Metode statistik yang digunakan untuk menguji hipotesis adalah SEM-PLS (Structural Equation Model – Partial Least Square). Hasil penelitian menunjukkan bahwa variabel likuiditas dan profitabilitas berpengaruh positif dan signifikan terhadap variabel nilai perusahaan.Kata Kunci: Likuiditas, Profitabilitas, Nilai Perusahaan
SOCIAL RESPONSIBILITY IN THE MANAGEMENT STRATEGY OF PHARMACY ORGANIZATIONS
Authors: Kareva N. , Shvecova V. 
Published: November 2021

The pharmacy business is one of the most important, as well as socially significant and socially responsible in the modern economy. Currently, the pharmacy sector of the Russian pharmaceutical market is experiencing a high level of development of the competitive environment and the search for competitive advantages of pharmacy organizations. However, the problem of social responsibility of the subjects of the pharmaceutical market remained outside the sphere of scientific interests of domestic scientists.
The aim of the study was to study social responsibility in the pharmacy business. The main method of collecting and analyzing information in the study was content analysis of materials from the official websites of Russian pharmacy chains. A practical argument for the choice of Internet resources as an empirical basis for the study was the desire to conduct a large-scale analysis of the features of the development of social responsibility of pharmacy chains with different economic opportunities.
The article presents the main characteristics of national regulatory documents on SSR issues, presents the results of the analysis of public information posted on the official websites of the TOP 100 pharmacy chains in Russia.
Book and Poetry Reviews
Authors: Davey Claire G. , Karioris Frank G. , Owen Craig 
Published: November 2021

Steven Angelides. The Fear of Child Sexuality: Young People, Sex and Agency (Chicago: The University of Chicago Press, 2019), 272 pp. ISBN: 978-0-226-64863-7. Paperback, $30.00.Stephan Torre. Red Obsidian: New & Selected Poems (Regina, Canada: University of Regina Press, 2021), 152 pp. ISBN 978-088-977775-0. Paperback, $19.95.James W. Messerschmidt. Hegemonic Masculinity: Formulation, Reformulation, and Amplification (London: Rowman & Littlefield, 2018), 181 pp. ISBN: 978-1-5381-1404-9. Paperback $32.00.
Rapid resolution of a traumatic venous epidural hematoma in a 3-year-old child: illustrative case
Authors: Wilhelmy Florian , Wende Tim , Kasper Johannes , Ablefoni Maxime , Bode Lena Marie , Meixensberger Jürgen , Nestler Ulf 
Published: November 2021

BACKGROUND
Posterior fossa epidural hematoma rarely occurs in children after traumatic head injury. There is ongoing discussion about appropriate treatment, yet the radiological features regarding the time to resorption of the hematoma or required follow-up imaging are rarely discussed.

OBSERVATIONS
The authors presented the case of a 3-year-old child who was under clinical observation and receiving analgetic and antiemetic treatment in whom near-complete hematoma resorption was shown by magnetic resonance imaging as soon as 60 hours after diagnosis. The child was neurologically stable at all times and showed no deficit after observational treatment. Hematoma resorption was much faster than expected. The authors discussed hematoma drainage via the sigmoid sinus.

LESSONS
Epidural hematomas in children can be treated conservatively and are resorbed in a timely manner.
Endovascular retrieval of a broken distal ventriculoatrial shunt catheter within the heart: illustrative case
Authors: Xu Jordan , Morchi Gira , Magge Suresh N. 
Published: November 2021

BACKGROUND
Displacement of a distal catheter of a ventriculoatrial (VA) shunt is a rare complication and can lead to a challenging extraction requiring endovascular retrieval of the distal catheter.

OBSERVATIONS
The authors describe a patient in whom the distal catheter of the VA shunt had become displaced and traveled through the tricuspid valve into the right ventricular outflow tract.

LESSONS
In this case report, the authors present a multidisciplinary approach to retrieving a displaced distal catheter from a VA shunt.
PENYALAHGUNAAN WEWENANG JABATAN OLEH PEJABAT NEGARA/PEMERINTAH : PERSPEKTIF HUKUM ADMINISTRASI NEGARA DAN HUKUM PIDANA
Authors: Sobirin Malian  
Published: November 2021

On November, 17, 2019, it was reported that the President Director of PT Garuda Indonesia Tbk. I Gusti Ngurah Askhara (Ari Askhara) got involved in the illegal Harley Davidson motorcycle parts and Brompton bikes found in the Garuda Indonesia aircraft. He was fired from the position. The case of the illegal spare parts by the Customs and Excise officers on the Airbus A330-900 Neo aircraft with the flight number GA 9721 on Sunday November, 17, 2019 is one more abuse of power among so many similar cases done by state officers. The case proves that an official power is vulnerable to corrupt. Abuse of power is as old as the age of human civilization. Abuse of power is an unlawful act done by a person or people in an official capacity. Abuse of power breaks the article 3 of the Indonesian Law No. 31 Year 1999 jo the Indonesian Law No. 20 Year 2001, that is “Anybody who with the intention to earn profit for himself or another person or a corporation, abuses the authority, opportunity or facilities given to him on account of his post or position which may cause loss to the state finance or state economy, shall be sentenced to life imprisonment or a minimum sentence of 1 (one) year and a maximum of 20 (twenty years) or a minimum fine of ..." It is a qualitative research methodology with observation and literary review to collect data. The research concludes that state administration officials should have professionally technical skills and morality to do their duties. If they do not have them, they might be fired in the perspective of administrative law and be sentenced to life imprisonment in the perspective of criminal law.
Upaya Hukum Terhadap Suspend Dalam Perjanjian Kemitraan Antara PT. Gojek Indonesia dengan Driver
Authors: Adriaman Mahlil 
Published: November 2021

Penetapan pelangaran yang dilakukan oleh driver Gojek menyebabkan suspend yang di keluarkan oleh PT. Gojek Indonesia. Suspend merupakan bentuk sanksi atas suatu pelanggaran dengan menonaktifkan suatu akun driver yang telah melakukan pelanggaran sehingga tidak dapat digunakan lagi baik untuk sementara maupun permanen. Terjadi wanprestasi salah satu pihak dalam pelaksanaan perjanjian kerjasama kemitraan antara PT. Gojek Indonesia dengan driver, maka penyelesaiannya dapat dilakukan dengan dua cara yaitu secara litigasi dan non litigasi. Hal tersebut diatur dalam Perjanjian Kerjasama Kemitraan Pasal 5 Ayat 1 mengenai Penyelesaian Sengketa. Berdasarkan pasal tersebut, ada dua cara yang ditempuh dalam penyelesaian sengketa, yaitu melalui musyawarah dan pengadilan.
Trauma Bonding: concepts, causes and mechanisms in intimate relationships
Authors: Fonseca Nicole de Queiroz Lima , Oliveira Bruno Quintino de 
Published: November 2021

When, after a violent incident, strong emotional bonds are established in order to connect two people, there is the installation of a trauma called by the literature as trauma bonding. It is an emotional dependence between two people, in a relationship characterized by periods of abuse, violence and power imbalance, with bonds of intense connection, cognitive distortion and behavioral strategies of both individuals that paradoxically strengthen and maintain the bond, which is reflected in the vicious cycle of violence. However, there is a lack of literature and scientific research on the subject in Brazil, which highlights the need for a refined and in-depth study, since the causes and effects of trauma bonding are still not exactly clear, which makes the understanding and treatment of individuals, as well as their recovery, a slow and painful process. Thus, this research is guided by the question: what is trauma bonding and what are its mechanisms? Thus, it was defined as the general objective to analyze trauma bonding in loving relationships, in order to give birth to the neuropsychobiological processes of trauma generated in intimate relationships and to investigate the reasons why victims remain in pathological relationships, we will also address the functioning of Stockholm Syndrome and posttraumatic stress in victims of abuse in loving relationships as factors that generate trauma bonding. For contextualization, problematization and validation of the theoretical framework used in the research undertaken, the methodology used was the literature review or bibliographic review, from the reading, selection and analysis of texts of different genres, such as records, reviews and scientific articles related to the subject and which were published in journals and newspapers in the area. It was concluded that several emotional and neuropsychobiological factors are the cause for trauma bonding to be established within a relationship.
Perbedaan Uji Efektivitas Ekstrak Buah Pepaya Dan Mentimun terhadap Bakteri Salmonella Thypi
Authors: Hermiaty Hermiaty , Karim Marzelina , Latief Shofiyah , Hidayati Prema H. , Ramadhani Suci 
Published: November 2021

Salmonella typhi adalah bakteri penyebab demam tifoid. Penyakit ini menyerang hampir di semua negara, terutama di negara-negara berkembang seperti Indonesia. Penyakit demam tifoid ini dapat tertular lewat makanan atau minuman yang terkontaminasi oleh feses atau urin dari orang yang terinfeksi. Di Indonesia kloramfenikol masih merupakan obat pilihan utama untuk mengobati demam tifoid. Namun banyak dilaporkan adanya resistensi S. typhi terhadap antibiotik kloramfenikol.Oleh karena itu, mulai dikembangkan penelitian untuk meminimalisir efek samping dari penggunaan antibiotik. Salah satunya adalah dengan pengembangan antimikroba yang berasal dari bahan alam. Salah satu tanaman yang dapat dimanfaatkan sebagai obat tradisional adalah tanaman pepaya (Carica papaya L memiliki nilai medis yang tinggi dan efek antibakteri . Adapun tanaman lain yang dapat di jadikan obat adalah mentimun (Cucumis sativus) dimana memiliki senyawa aktif yang berperan sebagai antifungi dan antibakteri. Mengetahui perbedaan daya antibakteri antara buah pepaya (Carica papaya L.) dan mentimun (Cucumis sativus L.) terhadap bakteri Salmonella thypi. Jenis penelitian yang dilakukan adalah penelitian eksperimental labatorium dengan metode yang digunakan pada penelitian ini adalah metode disc diffution. Zona hambat yang dihasilkan oleh ekstrak buah pepaya pada dua replikasi yaitu rata-rata diameter sebesar 0 mm dan 7 mm dan zona hambat yang dihasilkan oleh ekstrak buah mentimun untuk dua replikasi yaitu rata-rata diameter sebesar 0 mm dan 16,7 mm. Ekstrak buah mentimun dengan konsentrasi 100% lebih efektif karena memiliki daerah hambat yang lebih besar jika dibandingkan dengan ekstrak buah pepaya dengan konsentrasi 100%.
Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol
Authors: Lewis Celine , Buchanan James , Clarke Angus , Clement Emma , Friedrich Bettina , Hastings-Ward Jillian , Hill Melissa , Horn Ruth , Lucassen Anneke M. , Patch Chris , Pickard Alexandra , Roberts Lauren , Sanderson Saskia C. , Wynn Sarah L. , Vindrola-Padros Cecilia , Lakhanpaul Monica 
Published: November 2021

Background: A new nationally commissioned NHS England Genomic Medicine Service (GMS) was recently established to deliver genomic testing with equity of access for patients affected by rare diseases and cancer. The overarching aim of this research is to evaluate the implementation of the GMS during its early years, identify barriers and enablers to successful implementation, and provide recommendations for practice. The focus will be on the use of genomic testing for paediatric rare diseases. Methods: This will be a four-year mixed-methods research programme using clinic observations, interviews and surveys. Study 1 consists of qualitative interviews with designers/implementers of the GMS in Year 1 of the research programme, along with documentary analysis to understand the intended outcomes for the Service. These will be revisited in Year 4 to compare intended outcomes with what happened in practice, and to identify barriers and facilitators that were encountered along the way. Study 2 consists of clinic observations (pre-test counselling and results disclosure) to examine the interaction between health professionals and parents, along with follow-up interviews with both after each observation. Study 3 consists of a longitudinal survey with parents at two timepoints (time of testing and 12 months post-results) along with follow-up interviews, to examine parent-reported experiences and outcomes. Study 4 consists of qualitative interviews and a cross-sectional survey with medical specialists to identify preparedness, facilitators and challenges to mainstreaming genomic testing. The use of theory-based and pre-specified constructs will help generalise the findings and enable integration across the various sub-studies. Dissemination: We will disseminate our results to policymakers as findings emerge, so any suggested changes to service provision can be considered in a timely manner. A workshop with key stakeholders will be held in Year 4 to develop and agree a set of recommendations for practice.
Efecto de la suplementación con forrajes arbustivos sobre el desempeño productivo de conejos (Oryctolagus cuniculus)
Authors: Calderon-Bedoya Veronica Marcela , Castaño-Benitez Miguel Angel , Velásquez-Vélez Raul Adolfo 
Published: November 2021

Actualmente existe una alta demanda de alimentos balanceados destinados a la ceba de animales que resultan costosos, por lo tanto, los alimentos balanceados no convencionales son una alternativa para obtener buenos resultados a bajo costo; planteando como objetivo evaluar el efecto de la suplementación de diferentes forrajes en el desempeño productivo y rendimiento de la canal de 24 conejos machos raza Nueva Zelanda, distribuidos en 4 tratamientos con 6 individuos cada uno, determinando ganancia de peso, rendimiento de canal y costos de alimentación. Se realizó un análisis de medidas repetidas en el tiempo con el paquete estadístico SAS, encontrando que no hay diferencias significativas (p≤0,05) entre el Botón de oro y el alimento comercial, con respecto a peso final y rendimiento de la canal, identificando una disminución en costos, concluyendo que la suplementación con materias primas no convencionales es una alternativa para reducir los costos de producción, hasta un 59%.
Currently there is a high demand for balanced feeds intended for fattening animals that are expensive, therefore, unconventional balanced feeds are an alternative to obtain good results at low cost, consequently, the objective was to evaluate the effect of supplementation of different forages in the productive and carcass performance of 24 male New Zealand breed rabbits, distributed in 4 treatments with 6 individuals each one, measuring weight gain, carcass weight and feeding costs. It performed a repeated measures analysis over time with the SAS statistical package, there are no significant differences (p≤0,05) between Mexican sunflower and commercial feed, with respect to carcass performance, identifying a decrease in costs, concluding that supplementation with unconventional raw materials is an alternative to reduce production costs, up to 21,3%.
The Simulation of Muscles Forces Increases the Stresses in Lumbar Fixation Implants with Respect to Pure Moment Loading
Authors: Panico Matteo , Bassani Tito , Villa Tomaso Maria Tobia , Galbusera Fabio 
Published: November 2021

Simplified loading conditions such as pure moments are frequently used to compare different instrumentation techniques to treat spine disorders. The purpose of this study was to determine if the use of realistic loading conditions such as muscle forces can alter the stresses in the implants with respect to pure moment loading. A musculoskeletal model and a finite element model sharing the same anatomy were built and validated against in vitro data, and coupled in order to drive the finite element model with muscle forces calculated by the musculoskeletal one for a prescribed motion. Intact conditions as well as a L1-L5 posterior fixation with pedicle screws and rods were simulated in flexion-extension and lateral bending. The hardware stresses calculated with the finite element model with instrumentation under simplified and realistic loading conditions were compared. The ROM under simplified loading conditions showed good agreement with in vitro data. As expected, the ROMs between the two types of loading conditions showed relatively small differences. Realistic loading conditions increased the stresses in the pedicle screws and in the posterior rods with respect to simplified loading conditions; an increase of hardware stresses up to 40 MPa in extension for the posterior rods and 57 MPa in flexion for the pedicle screws were observed with respect to simplified loading conditions. This conclusion can be critical for the literature since it means that previous models which used pure moments may have underestimated the stresses in the implants in flexion-extension and in lateral bending.
Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
Authors: Yoshida Hiroshi , Ito Kumie , Manita Daisuke , Sato Ryo , Hiraishi Chika , Matsui Sadako , Hirowatari Yuji 
Published: November 2021

Background: Not only low-density lipoprotein (LDL) cholesterol but also non-high-density lipoprotein cholesterol (non-HDL-C), very low-density lipoprotein (VLDL) cholesterol (VLDL-C), and intermediate-density lipoprotein (IDL) cholesterol (IDL-C) are reported to be significant risk markers for coronary heart disease (CHD). We reported the relevance of IDL-C to Framingham risk score (F-score), but the present study addressed the relevance of IDL-C to Suita score (S-score), a risk score for coronary heart disease (CHD) developed for the Japanese individuals in addition to F-score.Methods: The cholesterol levels of lipoproteins, including triglyceride (TG)-rich lipoproteins (IDL and VLDL), were measured by an anion exchange high-performance liquid chromatography (AEX-HPLC). This study enrolled 476 men, aged mean 51 years and free of CHD and stroke.Results: Non-HDL-C, IDL-C, and VLDL-C significantly correlated with F-score and S-score. In the multiple stepwise regression analysis, IDL-C as well as body mass index (BMI) significantly correlated with both F-score and S-score in both the total subjects and the subjects without drug therapy. The multivariate logistic analysis with the model composed of BMI and IDL-C as the predictor variables demonstrated that 1 SD increase in IDL-C was an independent predictor for 10-year CHD risk &gt;10% of F-score (OR 1.534, 95% CI 1.266–1.859, p &lt; 0001) and that of S-score (OR 1.372, 95% CI 1.130–1.667, p = 0.0014) in the total subjects. Even in the subjects without the drug therapy, the increased IDL-C, as well as BMI, were significant predictors for 10-year CHD risk &gt;10% of S-score as well as F-score.Conclusion: These results suggest the significant relevance of the increased IDL-C for CHD risk scores in middle-aged men free of CHD and stroke. Further investigations are needed in women and elderly subjects.
Diagnostic Accuracy of the HAS-BLED Bleeding Score in VKA- or DOAC-Treated Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis
Authors: Gao Xinxing , Cai Xingming , Yang Yunyao , Zhou Yue , Zhu Wengen 
Published: November 2021

Background: Several bleeding risk assessment models have been developed in atrial fibrillation (AF) patients with oral anticoagulants, but the most appropriate tool for predicting bleeding remains uncertain. Therefore, we aimed to assess the diagnostic accuracy of the Hypertension, Abnormal liver/renal function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly, Drugs/alcohol concomitantly (HAS-BLED) score compared with other risk scores in anticoagulated patients with AF.Methods: We comprehensively searched the PubMed and Embase databases until July 2021 to identify relevant pieces of literature. The predictive abilities of risk scores were fully assessed by the C-statistic, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) values, calibration data, and decision curve analyses.Results: A total of 39 studies met the inclusion criteria. The C-statistic of the HAS-BLED score for predicting major bleeding was 0.63 (0.61–0.65) in anticoagulated patients regardless of vitamin k antagonists [0.63 (0.61–0.65)] and direct oral anticoagulants [0.63 (0.59–0.67)]. The HAS-BLED had the similar C-statistic to the Hepatic or renal disease, Ethanol abuse, Malignancy, Older, Reduced platelet count or function, Re-bleeding risk, Hypertension (uncontrolled), Anemia, Genetic factors, Excessive fall risk, Stroke (HEMORR2HAGES), the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA), the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT), the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF), or the Age, Biomarkers, Clinical History (ABC) scores, but significantly higher C-statistic than the Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, Stroke/transient ischemic attack history (CHADS2) or the Congestive heart failure/left ventricular ejection fraction ≤ 40%, Hypertension, Age ≥75 years, Diabetes mellitus, Stroke/transient ischemic attack/thromboembolism history, Vascular disease, Age 65–74 years, Sex (female) (CHA2DS2-VASc) scores. NRI and IDI values suggested that the HAS-BLED score performed better than the CHADS2 or the CHA2DS2-VASc scores and had similar or superior predictive ability compared with the HEMORR2HAGES, the ATRIA, the ORBIT, or the GARFIELD-AF scores. Calibration and decision curve analyses of the HAS-BLED score compared with other scores required further assessment due to the limited evidence.Conclusion: The HAS-BLED score has moderate predictive abilities for bleeding risks in patients with AF regardless of type of oral anticoagulants. Current evidence support that the HAS-BLED score is at least non-inferior to the HEMORR2HAGES, the ATRIA, the ORBIT, the GARFIELD-AF, the CHADS2, the CHA2DS2-VASc, or the ABC scores.