bluuebunny/crossref_metadata_2025_split huggingface dataset:
New options for cilostazol-based dual antiplatelet therapy for ischaemic stroke prevention in East Asian populations: a systematic review and meta-analysis
Authors: Wang Xiaorui , Wang Yixin , Zheng Qiang , Li Pengwei , Yin Jingli , Wang Miaomiao , Zou Liangyu , Wang Jie , Pan Jialin , Qin Lei , Luo Song , Yang Lijuan 
Published: February 2025

Background and purposeThe objective of this study is to systematically review the efficacy and safety of cilostazol-based dual antiplatelet therapy (DAPT) in patients with stroke.MethodsTwo reviewers conducted a comprehensive search of eligible studies published in PubMed, Medline, the Cochrane Library, Embase, and four Chinese databases from their establishment to 31 July 2024. The review was registered (CRD42024559047).ResultsThis study included a total of 4,473 subjects from 11 studies. The results indicated that, when compared to aspirin/clopidogrel single antiplatelet therapy (SAPT), cilostazol-based DAPT was associated with lower ischemic stroke (RR = 0.54, 95% CI 0.38–0.75, P = 0.0003) and any stroke recurrence (RR = 0.52, 95% CI 0.31–0.86, P = 0.01). Furthermore, the incidence of general adverse events was higher in the cilostazol-based DAPT (RR = 1.93, 95% CI 1.16–3.21, P = 0.01), while no statistically significant difference was observed between the two groups with regard to serious adverse events. The subgroup analysis of follow-up time revealed that the cilostazol-based DAPT regimen demonstrated superior efficacy in reducing the incidence of ischemic stroke recurrence (RR = 0.51; 95% CI 0.36–0.73; P = 0.0002) and any stroke recurrence (RR = 0.49; 95% CI 0.35–0.67; P &lt; 0.0001) in the long-term (&gt;3 months) versus the short-term (≤3 months) group. Furthermore, the cilostazol-based DAPT regimen did not increase the risk of serious adverse events.ConclusionDAPT combined with cilostazol and aspirin or clopidogrel was superior to aspirin or clopidogrel alone, did not increase serious adverse events, and was more effective for long-term (&gt;3 months) prophylaxis.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024559047
Dose-response relationship between carotenoid intake and risk of depressive symptoms in postmenopausal women
Authors: Li Xuexue , Wang Su 
Published: February 2025

BackgroundIt is well known that postmenopausal women have an increased risk of depression, and there is a dose correlation between carotenoid intake and depression. However, there is no clear study on the relationship between carotenoids and the risk of depression in postmenopausal women. To evaluate the relationship between the prevalence of depression and carotenoid intake in postmenopausal women.MethodsThe study was based on the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018 and included 1089 postmenopausal female participants. A logistic regression model was used to verify the relationship between carotenoid intake and the prevalence of depression in postmenopausal women. A restricted cubic spline (RCS) model was used to study the dose-response relationship between carotenoid intake and depression.ResultsAfter adjusting for confounding variables, Odds Ratios (95% confidence intervals) were found for depression in the highest quartile compared with the lower quartile. Among them, the results of lutein zeaxanthin and β-cryptoxanthin were not statistically significant (P &gt; 0.05). Total lycopene 0.29 (0.10,0.87), β-carotene 0.41 (0.18,0.94), and total carotenoid 0.25 (0.09,0.67) were negatively correlated with the risk of depression in postmenopausal women. When α-carotene intake exceeded 2.90 mg/day, it was negatively and non-linearly associated with the prevalence of depression in postmenopausal women (P-nonlinear &lt; 0.0022). When β-carotene intake exceeded 1.06 mg/day, it was negatively correlated with the prevalence of depression in postmenopausal women. It had an L-type nonlinear relationship with the prevalence of depression (P-nonlinear &lt; 0.0016). Total lycopene was linearly correlated with the prevalence of depression in postmenopausal women (P-nonlinear = 0.3). When the intake exceeded 2.05 mg/day, it was negatively correlated with the prevalence.ConclusionThe study found that dietary intake of sufficient α-carotene, β-carotene, lycopene, total lutein, and zeaxanthin was negatively correlated with the prevalence of depression in postmenopausal women. Still, there was no dose correlation between β-cryptoxanthin.
Relationship between disease perception and feelings of powerlessness in lymphoma patients: the mediating effect of social support and level of hope
Authors: Zhu Yingying , Hua Haiying , Sheng Li , Zhou Jingfen , Ye Long , Gu Siyu 
Published: February 2025

ObjectivesLymphoma patients often experience significant physical and psychological stress, with feelings of powerlessness negatively impacting their health. While social support and hope are crucial for improving mood and coping with disease, their mechanisms in relation to disease perception and powerlessness remain unclear. This study aimed to examine the relationship between disease perception and feelings of powerlessness in lymphoma patients, focusing on the mediating roles of social support and hope.MethodsFor a cross-sectional design, 311 lymphoma patients were surveyed using the Brief illness perception questionnaire, Powerlessness assessment tool, Social Support Rating Scale, and Herth’s Hope Scale, and were statistically analyzed using the software SPSS 27.0 and PROCESS version 4.1.ResultsA correlation was found between the disease perception, social support, hope level, and feeling of powerlessness of lymphoma patients (P &lt; 0.01). There was a positive correlation between perceptions of illness and powerlessness (β= 0.291, P&lt;0.001), and disease perception could influence powerlessness through three indirect pathways: the separate mediating effect of social support [β= 0.057, 95%CI (0.029~0.091)], the separate mediating effect of level of hope [β= 0.07, 95%CI (0.034~ 0.107)], and the chain mediating effect of social support and hope level [β= 0.019, 95%CI (0.008~0.033)]. Social support and level of hope played a partial medium mediating effect in the effect of perceived disease on feelings of powerlessness, accounting for 13.04% and 16.02% of the total effect, respectively, and the chained mediating effect of both accounted for 4.35% of the total effect.ConclusionsDisease perception and powerlessness were positively correlated in lymphoma patients, and in addition, social support and level of hope mediated the relationship. This conclusion provides a theoretical basis and guidance for nursing interventions to reduce powerlessness in lymphoma patients.
Evaluation of National Immunization Technical Advisory Groups (NITAGs) of middle-income countries in the WHO European Region; a synopsis
Authors: Külper-Schiek Wiebe , Mosina Liudmila , Jacques-Carroll Lisa A. , Falman Annika , Harder Thomas , Kakarriqi Eduard , Preza Iria , Badalyan Arman , Sahakyan Gayane , Romanova Oxana , Shimanovich Veronika , Musa Sanjin , Bayesheva Dinagul , Azimbayeva Nurshay , Nurmatov Zuridin , Toigombaeva Vera , Revenco Ninel , Gutu Veaceslav , Markovic-Denic Ljiljana , Bonaci-Nikolic Branka , Tursunova Dilorom , Tadzhiyeva Nigora , Wichmann Ole , Datta Siddhartha Sankar 
Published: February 2025

IntroductionA National Immunization Technical Advisory Group (NITAG) provides independent guidance to Ministries of Health (MoH) and policymakers, enabling them to make informed decisions on national immunization policies and practices. As of 2022, 50 of the 53 countries in the World Health Organization (WHO) European Region (the Region) had established a NITAG, with 58% of all NITAGs and 66% of those in middle-income countries (MICs) in the Region meeting all six WHO process indicators of NITAG functionality. However, many newly established NITAGs in MICs in the Region experience challenges in terms of their functioning, structure, and outputs.MethodsTo address these challenges and achieve the goal of evidence-informed decision making on immunizations, the WHO Regional Office for Europe and the Robert Koch Institute (RKI) implemented a project to strengthen the functioning of MIC NITAGs of the Region through comprehensive evaluations of nine NITAGs and development and implementation of improvement plans.ResultsAll evaluated NITAGs are formally established and complete the most important aspects of NITAG functioning. The main challenge for all NITAGs is the lack of a well-staffed Secretariat to establish annual workplans and develop NITAG recommendations following a standardized process.DiscussionThe evaluation identified NITAGs' strengths and challenges. Some challenges have been addressed through improvement plan implementation. WHO and RKI will continue to evaluate NITAGs and support development and implementation of improvement plans. WHO and NITAG partners will continue to provide training on the standardized recommendation-making process and advocate increased MoH support to NITAGs, including dedicated Secretariat staff.
Health literacy and associated factors among adult type 2 diabetic patients in Woldia Comprehensive Specialized Hospital, North-East Ethiopia, 2022
Authors: Mulugeta Abate Habtemariam , Kumar Prem , Anteneah Samuel , Girma Mitaw , Yimam Wondosen , Desu Birhanu 
Published: February 2025

BackgroundDespite limited research, health literacy in developing countries like Ethiopia remains low, making it a significant challenge to combat non-communicable diseases.ObjectiveTo assess the level of health literacy and associated factors among adult type 2 diabetic patients in Woldia Comprehensive Specialized Hospital, North-East Ethiopia, 2022.Methods and materialsA cross-sectional study was conducted at Woldia Comprehensive Specialized Hospital from April 19 to July 19, 2022, involving 423 participants. Systematic random sampling, face-to-face interviews, and document reviews were used to collect data. The data were coded and entered into Epi-Data version 4.6.0.2, then analyzed using Statistical Package for the Social Sciences (SPSS) version 26. The results were presented in texts, tables, and figures. Bivariable and multivariable logistic regression analyses were performed to identify significant predictors with p-values below 0.05 and to verify the assumptions of binary logistic regression.ResultGeneral Health Literacy Index was 27.86 (±6.71), and the magnitude of participants with adequate health literacy in the study was 22.2% (95% CI: 18.4–26.3%). Ages (18–35) years [(AOR =14, 95% CI = 3.86–50.77)], ages (36–50) years [(AOR = 15.38, 95% CI = 4.23–55.9)], being male [(AOR = 2.945, 95% CI = 1.570–5.526)], no experiencing depression symptoms [(AOR = 2.673, 95% CI = 1.308–5.463)], not experiencing anxiety [(AOR = 2.001, 95% CI = 1.011–3.960)] and being literate [(AOR = 4.120, 95% CI = 1.397–12.146)] were significantly associated with adequate health Literacy.Conclusion and recommendationsThe magnitude of adequate health literacy was low. Ages (18–35) years, ages (36–50) years, being male, not experiencing depression symptoms, not experiencing anxiety, and being literate were significantly associated with adequate health literacy. Health professionals should regularly implement health education programs for diabetic patients and communities, focusing on females, older adults, the illiterate, and those experiencing depression and anxiety.
Optimization of school physical education schedules to enhance long-term public health outcomes
Authors: Tao Sun , Sheng-ping Zhu , Meng-yuan Wang 
Published: February 2025

IntroductionOptimizing school physical education (PE) schedules is crucial for enhancing public health outcomes, particularly among school-aged children.MethodsTherefore, in this study, a weighted fitness function is developed to evaluate health fitness scores. This function integrates multiple health metrics such as BMI reduction, fitness improvement, calories burned, and heart rate reduction. Six optimization algorithms such as Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO), Simulated Annealing (SA), Differential Evolution (DE), and Artificial Bee Colony (ABC) optimization algorithms are utilized to optimize PE schedules based on the designed weighted fitness function. Using a dataset of 1,360 student entries, the study incorporates health metrics such as BMI reduction, fitness score improvement, caloric expenditure, and heart rate reduction into a weighted fitness function for optimization.ResultsThe results show that ACO achieved the highest allocation of PE time (9.91 h/week), the most significant caloric expenditure (370 kcal/session), and the greatest reduction in heart rate (8.5 bpm). GA excelled in the reduction of BMI, achieving a decrease of 10.63 units.DiscussionThese analyses reveal the transformative potential of optimized PE schedules in reducing the burden of lifestyle-related diseases, promoting equitable health outcomes, and supporting cognitive and mental well-being. Finally, recommendations are provided for policymakers and stakeholders to implement data-driven PE programs that maximize long-term public health benefits.
Comparison of body mass index and physical activity levels of e-sportsmen
Authors: Başoğlu Burhan 
Published: February 2025

BackgroundThis study examines the relationship between body mass index (BMI) and physical activity levels in e-sports players. Focusing on the sedentary lifestyle and health risks associated with prolonged sitting and low physical activity, the study highlights critical challenges within the e-sports community.MethodsData was collected from 136 e-sports players on popular gaming platforms such as FIFA, Valorant, CS: GO and League of Legends. Physical activity levels were assessed using the International Physical Activity Questionnaire (Short Form) and participants’ health status was assessed using BMI classifications.ResultsThe results showed a significant inverse relationship between BMI and physical activity, with obese e-sports players having significantly lower activity levels and longer periods of sedentary behavior than their peers. Male e-sports players had higher levels of physical activity than females, reflecting biological, social and cultural factors that influence physical activity behavior.DiscussionThe study highlights the need for measures such as training programs, ergonomic adjustments and awareness campaigns to increase physical activity and reduce health risks among e-sports players. These findings provide valuable insights into the health effects of e-sports participation and emphasize the importance of promoting an active lifestyle to counteract the detrimental effects of prolonged sitting and inactivity. By filling gaps in the existing literature, this study contributes to the understanding of e-sports players’ health behaviors and offers practical recommendations for promoting healthier habits in this growing population.
The Brons-Mulié analysis as a decision-making tool for preoperative surgical simulation in orthognatic surgery
Authors: Böttger Sebastian , Nowak Yannick , Windhorst Anita Cornelia , Klaus Katharina , Ruf Sabine , Bäcker Christina , Schraml Eva May , Danevitch Nina , Mulié Rob , Howaldt Hans-Peter , Attia Sameh 
Published: February 2025

ObjectivesSufficient preoperative planning represents an essential component for the success of orthognathic surgery. Using various analysis methods, dysmorphic areas can be reliably identified and addressed during the planning procedure.MethodsBrons-Mulié analysis was used to examine profile photographs before and after orthognathic surgery. The attainment of normal values was interpreted as the achievement of facial harmony of the various facial proportions. By comparing the pre- and postoperative analysis, a control of the outcome quality of the orthognathic procedures was performed.ResultsIn a total of 160 patients aged 13 to 61 years, the preoperative analysis could be compared with the postoperative Brons-Mulié analysis. Postoperative, facial harmony was found for the vertical dimension in 99 cases (62%), for the upper lip dimension in 95 cases (59%), for the lower lip dimension in 138 cases (86%), and for the chin dimension in 118 cases (74%). This corresponded to an improvement of 20% in the vertical dimension, of 27% in the area of the lower lip and of 6% in the area of the chin. The upper lip area showed a slight deterioration of 7%.ConclusionDespite preoperative planning of orthognathic surgery with Brons-Mulié analysis, postoperative results show an overall improvement but not perfection. Even by applying the method, it remains a challenge to achieve perfect facial harmony.
Hybrid barn: the switch from a naturally to a mechanically ventilated turkey barn to protect from harmful bioaerosols
Authors: Sake Björn , Butenholz Kira , Kempf Katrin , Kemper Nicole , Schulz Jochen 
Published: February 2025

IntroductionAnimal health is essential to ensure the highest level of animal welfare and to conserve resources. Especially in naturally ventilated barns, the airborne entry of pathogens is difficult to avoid. For instance, birds in naturally ventilated turkey barns are frequently infected by highly pathogenic avian influenza and the airborne route may play a role. In this study, a naturally ventilated turkey barn was equipped with filter modules that allow a conversion to a mechanically ventilated barn.MethodsFour filter modules with two filter stages were adapted to a turkey barn and the curtains were closed to induce a slight overpressure in the barn. Air samples were taken over the course of 16 months in front of and behind the filter units to assess the filter efficiencies. Filter efficiencies were evaluated by the reduction of particle classes (PM1, PM10, nanoparticles), microorganisms (total bacteria, molds, yeasts), and the detection of potentially pathogenic bacteria and viruses by PCR tests.ResultsParticle reduction rates were 94.17% for PM1, 94.27% for PM10, and 95.80% for nanoparticles, respectively. Total bacteria counts were reduced by 95.88%, molds by 94.64%, and yeasts by 66.03%. Ornithobacterium rhinotracheale was significantly retained in the filter units. The results for influenza A also indicated that the entry of potentially infectious particles could be prevented.DiscussionThe flexible switch from a naturally to a mechanically ventilated barn with filtered supply air can be an innovative solution to avoid airborne pathogen entry in risky situations and may represent a component in the strategy to control epidemic diseases.
Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: enhanced immune response in piglets with CD154 molecules
Authors: Li Yuwan , Zeng Weijun , Niu Xinni , Yuan Zhongmao , Li Shurou , Lin Jinru , Xie Kaiyuan , Zhu Zixiang , Yi Lin , Ding Hongxing , Zhao Mingqiu , Fan Shuangqi , Chen Jinding 
Published: February 2025

IntroductionFoot-and-mouth disease (FMD) is a highly contagious disease caused by FMDV, resulting in vesicular lesions in cloven-hoofed animals and posing significant economic threats to the livestock industry. VLP vaccines, which lack viral genetic material and are non-infectious, demonstrate superior safety compared to traditional inactivated vaccines. This study employs ADDomer, a novel adenovirus-based VLP framework, to display FMDV antigenic epitopes on the VLP surface. Additionally, FMDV capsid proteins can assemble into VLPs, offering innovative approaches for developing more efficient and safer FMDV vaccines.MethodsTwo FMDV VLP proteins were constructed using a baculovirus expression system. One VLP was developed by embedding the B-cell epitope of FMDV VP1 into the G-H loop of VP3 and co-expressing it with VP1 and VP0 to form VP1-VP3B-VP0. The other VLP, ADDomer-BBT, fused B-and T-cell epitopes from FMDV O-type VP1 into the ADDomer platform, with porcine CD154 expressed as an immune enhancer. Expression conditions were optimized, and proteins were purified. The VLPs, combined with porcine CD15 molecular adjuvant, were evaluated for immunogenicity in piglets.ResultsAfter purification, both VLPs displayed virus-like structures under electron microscopy. Immunization in piglets induced high levels of FMDV-specific and neutralizing antibodies, enhanced cytokines IL-2, IL-4, and IFN-γ, and increased lymphocyte proliferation. The CD154-added group showed higher immune responses.DiscussionThe VLP vaccines effectively induced strong cellular and humoral immune responses, with CD154 enhancing efficacy. These findings provide insights for developing safer, more effective FMDV vaccines and contribute to advancing livestock health and productivity.
Rancang Bangun Sistem Pemantauan Tekanan dan Suhu Ban Berbasis Internet of Things dan Software Defined Radio
Authors: Briantoro Hendy , Budikarso Anang , Arifin  , Moegiharto Yoedy , Yanuar Hariyawan Mohammad 
Published: February 2025

Terdapat banyak kecelakaan kendaraan bermotor di jalan, salah satu penyebabnya adalah ban kendaraan yang pecah. Kecelakaan tersebut terjadi disebabkan karena pengemudi terus mengendarai kendaraannya meskipun tekanan dan suhu ban melebihi ambang batas yang ditentukan. Untuk mengatasi hal tersebut, maka perlu adanya sistem pemantauan tekanan dan suhu ban kendaraan yang dapat terus-menerus dipantau oleh pengemudi. Jika terjadi kesalahan pada perangkat pemantauan di dashboard kendaraan, pengemudi dapat diingatkan oleh pihak lain yang juga memantau informasi tekanan dan suhu ban secara jarak jauh. Dalam penelitian ini, kami membuat sistem pemantauan tekanan dan suhu ban kendaraan yang bisa diakses secara jarak jauh menggunakan teknologi Internet of Things (IoT). Selain itu, kami menggunakan teknologi Software Defined Radio (SDR) untuk pembacaan data tekanan dan suhu. Sistem ini berhasil memantau perubahan tekanan dan suhu ban secara jarak jauh melalui komputer dan smartphone. Berdasarkan hasil pengujian, nilai standar deviasi terbaik untuk nilai tekanan ban adalah 3,54. Sedangkan nilai standar deviasi terbaik untuk nilai suhu ban adalah 1,72.
A type of focused single-mode A0 Lamb wave EMAT for performance improvement
Authors: Peng Shunli , Fan Zubang , Wu Yunxin , Zhang Tao , Yang Xufei 
Published: February 2025

Abstract
In this paper, a Halbach array periodic permanent magnet (HPPM) electromagnetic acoustic transducer (EMAT) was proposed for generating stronger and purer A0 mode Lamb wave (A0 wave). Compared to conventional periodic permanent magnets (PPM), the HPPM generates a more intense and purer horizontal magnetic field, enhancing A0 wave amplitude by 28% and suppressing the S0 mode Lamb wave (S0 wave) by 32%. Additionally, a focused A0 wave EMAT (FHPPM-EMAT) with arc structure is proposed. The FHPPM-EMAT demonstrates excellent transduction efficiency and focusing capability. An orthogonal analysis was conducted to evaluate the factors affecting the transduction efficiency of the FHPPM-EMAT. With optimized parameters based on orthogonal analysis, the FHPPM-EMAT achieved a 93% increase in A0 wave amplitude compared to the HPPM-EMAT. Furthermore, the size of the focal area is characterized by a horizontal focal width (Hd) and a vertical focal width (Vd) of only 36.21 mm and 10.45 mm, respectively.