bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological significance and prognosis of long noncoding RNA SNHG14 expression in human cancers: A Meta-Analysis and bioinformatics analysis
Authors: Liu Bin , Lu Tingting , Wang Yongfeng , Chen Yaqiong , Ma Shixun , Jiao Yajun , Yang Kehu , Cai Hui 
Published: December 2021

Abstract
Background

SNGH14 is a recently found long non-coding RNA (lncRNA) with a strong link to cancer. However, it is uncertain if the expression of SNHG14 is linked to the prognosis of individuals with various forms of cancer. We conducted a meta-analysis of the available literature to evaluate the association between SNHG14 and clinicopathological characteristics and patient prognosis
Methods

The databases PubMed/Medline, Web of Science, Cochrane Library, and Embase were combed for relevant papers published till November 2021. The odds ratio (OR) and 95% confidence interval (CI) were used to analyze dichotomous variables, while the hazard ratio (HR) and 95% CI were employed as a summary statistic for survival outcomes. In addition, the Cancer Genome Atlas TCGA (TCGA) and gene expression omnibus (GEO) database were utilized to investigate SNHG14 differential expression in pan-cancers. Cox regression and Kaplan-Meier analysis were used to investigate the prognostic significance of SNHG14 in pan-cancer. The association between the degree of SNHG14 expression in pan-cancer and immune infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI) was measured using Spearman correlations.
Results

A total of 21 studies with 1,080 patients, mainly from China, were included. Our results showed that elevated SNHG14 expression was significantly associated with poor overall survival (OS) (HR = 1.39; 95% CI: 1.06-1.83; P = 0.017). In addition, increased SNHG14 expression was associated with tumor size (OR = 1.60; 95% CI: 1.20-2.14; P = 0.001), TNM staging (OR = 0.54; 95% CI: 0.40-0.71; P <0.001), lymph node metastasis (OR = 1.86; 95% CI: 1.35-2.55; P <0.001), differentiation grade (OR = 1.95; 95% CI: 1.36-2.80; P <0.001), and distant metastasis (OR = 2.44; 95% CI: 1.30 -4.58; P= 0.005). However, there was no significant difference in age (OR = 1.02; 95% CI: 0.77-1.33; P = 0.863) and gender (OR = 0.98; 95% CI: 0.72-1.35; P = 0.915).
Conclusion

This study revealed that overexpression of SNGH14 is associated with low OS rate and clinicopathological characteristics. SNGH14 can be considered as a new tumor marker that aids in early tumor diagnosis, thus improving the prognosis of patients.
TGTDCL Prepaid Domestic Gas Metering System &amp; Reduction of System Loss in the Energy Sector of Bangladesh
Authors: Nargis  
Published: December 2021

Abstract
Titas Gas Transmission and Distribution Company Limited (TGTDCL) is the largest gas transmission and distribution company in Bangladesh. The company undertook a pilot project in July 2005 to implement pre-paid metering on a limited scale. The outcomes of the pilot project are analyzed and presented in this paper. Most of the customers under the project appear to be indifferent to the new system. The revenue of TGTDCL was less compared to the same number of un-metered customers. The pilot project has a lack of design, planning, and implementation errors. Calculations are therefore made based on the assumed parameters. Clear and conclusive results regarding the reduction of gas wastage and financial benefits are hard to determine.
Gut mucus layer degradation is associated with aggressive cervical cancer phenotype
Authors: Colbert Lauren E. 
Published: December 2021

Abstract
Background

Gut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, and increased gut diversity is associated with improved outcomes after treatment. We proposed that functions of specific microbial species adjoining the mucus layer may directly impact the biology of CC.
Results

In this study, we examined metagenomes of rectal swabs in 41 CC patients using whole-genome shotgun sequencing and found a significant association between molecular functions encoded by the metagenomes with markers of aggressive cancer including initial tumor size and stage. Profiling of the molecular function abundances and their distributions identified 2 microbial communities co-existing in each metagenome but with distinct metabolism and taxonomic structures. Community A (Clostridia and Proteobacteria predominant) was characterized by high activity of pathways involved in stress response, mucus glycan degradation and utilization of degradation byproducts. This community was prevalent in larger, advanced stage tumors. Conversely, community B (Bacteroidia predominant) was characterized by fast growth, active oxidative phosphorylation, and production of vitamins. This community was prevalent in small, early-stage tumors.
Conclusions

Based on these results, we propose that increased mucus layer degradation is associated with a more aggressive cervical cancer phenotype.
Gobernanza y Calidade en la Educación Superior: Una Descripción Bibliométrica
Authors: Pedraja-Rejas Liliana , Rodríguez-Ponce Emilio , Muñoz-Fritis Camila 
Published: December 2021

Considerando que las universidades contemporáneas enfrentan una presión significativa para reestructurar sus prácticas de dirección, es que este artículo se propone como objetivo identificar las tendencias de la producción científica en relación a la gobernanza y la calidad en el campo de la educación superior. Para esto, se desarrolló un análisis bibliométrico de los artículos de revistas indexadas en Web of Science publicados entre los años 2010 y 2020. Para el análisis de datos y la visualización de mapas bibliométricos se utilizaron los programas computacionales Bibliometrix y VOSviewer. Los resultados evidencian un aumento en la producción científica si se comparan los años extremos del período analizado. Asimismo, se identificaron tres temas principales de investigación, a saber, 1) leyes y reformas a la educación superior, 2) percepciones de los académicos sobre las reformas, el nuevo escenario docente y sus niveles de satisfacción, y 3) compromiso y participación del estudiante. Se concluye que desde una perspectiva transversal el liderazgo de los directivos, la participación y el pensamiento crítico de los estudiantes, así como también la colaboración entre instituciones de educación superior son aspectos esenciales para que estas lleven a cabo sus roles con énfasis en la calidad.
Finalmente se proyecta un campo con publicaciones en aumento que aborden esta temática a partir del contexto de la educación superior en el que aspectos como la desregulación, la búsqueda de la calidad y la necesidad de autonomía financiera se perciben como necesidades urgentes.
ENTRE LINHAS, TESOURAS E MÁSCARAS, COSTURANDO SOLIDARIEDADE
Authors: Cristina Souza Lacerda Melo de Souza Alice , Antunes Cleuza , Mendonça dos Santos Lima Andréia , Cristina Pereira Luciana 
Published: December 2021

O relato descreve as ações desenvolvidas no projeto Entre linhas, tesouras e máscaras, costurando solidariedade, que teve por objetivo fortalecer a extensão no IFRO, por meio de parcerias para minimizar os efeitos da pandemia no município, com a confecção e distribuição de máscaras caseiras de tecido a grupos socialmente vulneráveis. Realizado em duas etapas o projeto foi desenvolvido entre os meses de Maio de 2020 a Janeiro de 2021. Conclui-se que o projeto alcançou os objetivos propostos uma vez que as máscaras distribuídas alcançaram grupos vulneráveis colaborando para a proteção dos indivíduos que precisaram circular pela sociedade bem como os que ficaram isolados porém em grupos, como é o caso dos indígenas aldeados.

Palavras-chave: Ações de extensão; Prevenção; Corona Vírus; Máscaras de tecido.
Mapeamento e descrição de características de repositórios multidisciplinares de dados científicos abertos
Authors: Lucas Elaine Rosangela de Oliveira , Picalho Antonio Carlos , Caitano Vitória Maria Hartmann 
Published: December 2021

O compartilhamento de dados científicos possibilita acelerar a construção de novos conhecimentos, aumentando a eficiência dos recursos, ampliando as possibilidades de reuso e de reprodutibilidade de pesquisas. Com a finalidade de apresentar um conjunto de informações com características de repositórios de dados científicos abertos, definiu-se como objetivo para este estudo caracterizar e mapear os repositórios de dados científicos abertos como alternativa para a tomada de decisão institucional no campo da gestão de dados científicos. Realizou-se um estudo exploratório-descritivo, qualitativo e, com relação aos procedimentos técnicos, um levantamento bibliográfico-documental, em que foram analisados seis repositórios de dados científicos abertos: DANS, DataHub, Harvard-Dataverse, Dryad, Figshare e Zenodo. A partir de informações coletadas dos sites oficiais de cada um desses repositórios entre abril e maio de 2021, foram observadas características referentes às seguintes categorias de análise: fundação e responsabilidade pelo mantenimento do repositório; idiomas da plataforma e dos datasets aceitos, mídias sociais e possibilidade de compartilhamento direto de conteúdo; tipos e formatos de arquivos aceitos, limites de uso, curadoria de conteúdo; identificadores persistentes de conteúdo, de autores e informações acerca de financiamento de pesquisa; controle de versões; métricas de uso; integração com outros aplicativos e custos. A análise dos sites dos repositórios gerou um quadro, disponibilizado no repositório Zenodo, com a descrição dos dados de cada repositório a partir das categorias. Com os resultados apresentados pretende-se auxiliar os pesquisadores na sua escolha por um repositório de dados científicos abertos que permita o compartilhamento dos dados da pesquisa.
Recent Advances in the Synthesis of Benzothiazole and its Derivatives
Authors: Qadir Tanzeela , Amin Andleeb , Salhotra Alka , Sharma Praveen Kumar , Jeelani Ishtiaq , Abe Hitoshi 
Published: December 2021

Abstract:Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.
Recent Advances in the Application of Barbituric Acid Derivatives in Multicomponent
Reactions
Authors: Ziarani Ghodsi Mohammadi , Khademi Mahdieh , Mohajer Fatemeh , Yadav Sangeeta , Tomar Ravi 
Published: December 2021

Abstract:
Barbituric acid is a pyrimidine heterocyclic organic compound, which is pharmacologically
active. It is important to build structures containing various medicinal activities. This
compound attracts the scientific research community in organic synthesis. It can be used in the
synthesis of polyheterocyclic, natural, medicinal compounds, and organic sensors. Herein, the
utilization of barbituric or thiobarbituric acid in multicomponent reactions is reported from
2016-2021 in this manuscript.
Plumbagin: A Potential Candidate for Future Research and Development
Authors: Thakor Niyatee , Janathia Bhavyata 
Published: December 2021

Abstract:
Plumbagin has gained a lot of attention in research due to its various therapeutic actions. It is
a secondary metabolite obtained from different plant families, such as Plumbaginaceae, Droseraceae,
and Ebenceae. Various studies on plumbagin have revealed that it is a natural gift for mankind in treating
chronic diseases, like cancer, diabetes, malaria, bacterial infection, and controlling cardiovascular
disease. However, there are several challenges in developing plumbagin as a therapeutic agent. The first
and foremost is its limited solubility and oral bioavailability. The second limitation is its toxicity. Plumbagin
has a narrow therapeutic window, and literature reveals that the compound has moderate toxicity
in animals. However, data are insufficient to prove that plumbagin is unsafe for humans. Despite the
many therapeutic benefits of plumbagin, it remains unexploited for mankind. Thus, a systematic review
of its toxicity, pharmacology, and safety is required to be performed. This review work signifies the
depth of therapeutic applications proven via research, its different modes of isolation and separation of
chemical constituents, and its modification. A thorough review of promising therapeutic targets via
docking studies is also presented. Different methods used to quantify plumbagin from the plant are reviewed.
An overview of attempts to design novel formulations which could enhance its bioavailability
is also presented. The review paper will help the scientist to exploit the drug to its optimum, which will
help to overcome the challenges faced during its design and developmental stages.
Metabolomics of Meat Color: Practical Implications
Authors: Ramanathan Ranjith , Denzer Morgan L. , Kiyimba Frank , Mafi Gretchen G. 
Published: December 2021

Objective:
Meat is biochemically active. Various pre-and post-harvest processes affect
meat quality. Metabolomics is a valuable tool to elucidate metabolite changes in meat. The overall
goal of this mini-review was to provide an overview of various techniques, data analysis, and application
of metabolomics in meat color research.

Results:
Both targeted and non-targeted approaches are used to determine metabolite profiles in
meat. Researchers use gas-, liquid-chromatography, and nuclear magnetic resonance platforms to
separate molecules. Metabolomics is used to characterize muscle-specific differences in color stability,
meat tenderness, the impact of aging on meat color, and to determine metabolite profile differences
between normal-pH and dark-cutting beef. Color stable muscles have more glycolytic
metabolites than color labile muscles.

Conclusion:
The use of metabolomics has greatly enhanced our understanding of metabolites' role
in meat quality. There is a need for multiple databases to obtain comprehensive metabolite libraries
specific to food. Metabolomics in combination with wet-laboratory techniques can provide novel
insights on the relationship between postmortem metabolism and meat color.
Clinical Value of COVID-19 Chest Radiography and High-Resolution CT
Examination
Authors: Wang Dan , Shang Yalei , Chen Yuehua , Xia Jianguo , Tian Weizhong , Zhang Tao , Dai Hui , Li Yonggang 
Published: December 2021

Background:
Novel coronavirus disease 2019 (COVID-19) pneumonia remains a matter
of concern. Chest CT findings of COVID-19 pneumonia have been reported widely, while there is
relatively rare research on chest X-ray (CXR).

Objective:
The study was aimed to compare the CXR and chest CT findings of patients with confirmed
COVID-19 infection and to explore their respective clinical values.

Methods:
28 inpatients with COVID-19 pneumonia who underwent both CXR and CT were included.
The pulmonary manifestations of the lesions were recorded. Ground-glass opacity (GGO), consolidation,
and fibrosis were quantified in CXR and chest CT separately. Consistency was analyzed
using Fleiss' kappa and intraclass correlation coefficient. The stages of the disease in CXR and chest
CT were evaluated.

Results:
Approximately 67.9% (19/28) of subjects had abnormal findings on CXR. The common
manifestations in CXR were ground-glass opacities (GGO) (100%, 19/19) and consolidation
(68.4%, 13/19). 92.9% (26/28) of patients had abnormal manifestations on CT. The common manifestations
in CT were GGO (88.5%, 23/26), consolidation (69.2%, 18/26), reticular opacity
(69.2%, 18/26) and nodule (46.2%, 12/26). Among the abnormalities between CXR and CT, only
consolidation was consistent (κ=0.510). GGO (ICC=0.501) and consolidation (ICC=0.431) scores
were consistent in CXR and chest CT. The results of staging were the same in 14 cases, most of
them were in stage I and stage II. While in other cases with inconsistent results, CT was more advanced
in the disease stage than CXR, mainly stage III and stage IV.

Conclusion:
CXR is helpful to observe the change of the pulmonary lesions in patients with confirmed
COVID-19 pneumonia. CT can be used for early diagnosis and staging of lesions.
Chemopreventive Role of Phytoconstituents in Breast Cancer: An Integration Therapy
Authors: Bhatt Priya , Patel Mehul , Thakkar Aashka , Shah Umang , Patel Ashish , Solanki Nilay , Patel Swayamprakash , Patel Sandip 
Published: December 2021

Abstract:
As we enter into the era of modern medicine, breast cancer remains a significant public
health concern that has a noteworthy global impact in developed and developing countries. The
modern era has seen an increase in the knowledge of the molecular mechanisms underlying cancer
progression, leading to many anticancer drugs. The practice of curing certain diseases with the help
of plant-derived compounds was one of the traditional methods. Phytochemicals and derivatives
present in plants have shown a promising effect for improving efficiency in the treatment of cancer
patients and reducing adverse reactions such as integration therapy with chemotherapeutic agents.
The primary objective of this review is to compile ongoing research, preclinical studies, and clinical
trials of some of the important phytochemicals. In recent years, increasing evidence from preclinical
and clinical studies suggests that phytochemicals can favorably modulate several signaling
pathways involved in cancer development and progression. Furthermore, phytoconstituents or plant-
derived compounds show synergistic action against breast cancer when integrated with chemotherapy.
Thus, the therapeutic potential of naturally occurring phytochemicals is of great interest
as a part of integration therapy in cancer care. This review focuses on phytochemicals from quinones,
terpenoids, alkaloids, polyphenols, steroidal lactones, and glycosides classes that help treat
breast cancer. In addition, the phytochemicals act by various pharmacological mechanisms like carcinogen
inactivation, inhibiting proliferation, cell cycle arrest, and apoptosis. Collectively, detailed
information about specific classes of phytoconstituents along with their mechanism of action is
mentioned in this review.
Contribution of Organic Bee Pollen to the Determination of Botanical Origin of Honey and its Impact on its Biological Properties
Authors: Amessis-Ouchemoukh Nadia , Otmani Amar , Mouhoubi-Tafinine Zina , Tighlit Kenza , Redouan Ibtissam , Terrab Anass , Ouchemoukh Salim 
Published: December 2021

Background:Honey is a sweet and flavorful natural product that comes from a lot of nectar of medicinal plants.Objective:This study aimed to determine the botanical origin, physicochemical parameters, antioxidant contents, and antibacterial activities of Algerian honey.Method:The physicochemical parameters of the honey analyzed were measured using the methods established by the European Honey Commission. The antioxidant contents were determined using colorimetric assays, and the antioxidant activities were estimated using reducing power, DPPH, ABTS, and FRAP assays. Antibacterial activities were measured using sensitivity testing and minimal inhibitory concentration.Results:The majority of the samples analyzed were monofloral honey (Fabaceae), and other medicinal plant pollens were identified as minor and very minor pollen (Asteraceae, Tiliaceae, Myrtaceae, and Apiaceae). The physicochemical parameters of the honey were in accordance with the legislation, and the analyses of proline and HMF confirmed their authenticity. The content of total phenolic compounds and total flavonoids ranged from 26 to 159 mg GAE/100 g and 10 to 43 mg EC/100 g, respectively. The analyzed samples of honey showed variable antioxidant activities that differed from one honey to another, and antibacterial activity tests showed that S. aureus and K. pneumoniae were the most sensitive strains with inhibition zones of 24 to 28 mm and 8 to 35 mm in diameter, respectively. Very high correlations were observed between color, antioxidants, and antioxidant activities.Conclusion:This study confirmed the powerful properties of honey to trap free radicals and inhibit bacterial growth, thus it could be used as a therapeutic agent.
Elegant, Flexible Vesicular Nanocarriers for the Efficient Skin Delivery of
Topically Applied Drugs
Authors: Albalawi Waleed , Alharbi Surur , Alanazi Fahad , Alahmadi Hameed , Alghamdi Mothib , Soliman Ghareb M. , Safwat Mohamed A. 
Published: December 2021

Background:
Skin diseases represent a major health concern worldwide and negatively
impact patients’ quality of life. Despite the availability of various efficacious drugs, their therapeutic
outcome is often limited due to shortcomings related to the formidable skin barrier and unfavorable
physicochemical properties of drugs. Flexible nano-vesicles have shown tremendous potential to
overcome these hurdles and improve the local therapeutic effect of these drugs.

Objective:
This review article is aimed to shed light on flexible nano-vesicular carriers as a means to
combat skin diseases.

Methods:
The literature was reviewed using PubMed database using various keywords such as liposomes,
flexible (deformable liposomes) (transferosomes), ethosomes, transethosomes, niosomes, and
spanlastics.

Results:
Liposomes and niosomes were found effective for the loading and release of both hydrophilic
and lipophilic drugs. However, their limited skin penetration led to drug delivery to the
outermost layers of skin only. This necessitates the search for innovative vesicular carriers, including
liposomes, flexible (deformable liposomes), ethosomes, transethosomes, and spanlastics. These
flexible nano-vesicular carriers showed enhanced drug delivery and deposition across various skin
layers, which was better than their corresponding conventional vesicles. This resulted in superior
drug efficacy against various skin diseases such as skin cancer, inflammatory skin diseases, superficial
fungal infections, etc.

Conclusion:
Flexible nano-vesicular carriers have proven themselves as efficient drug delivery systems
that are able to deliver their cargo into the deep skin layers and thus, improve the therapeutic
outcome of various skin diseases. However, there remain some challenges that need to be addressed
before these nanocarriers can be translated from the lab to clinics.
Stem Cells from Human Exfoliated Deciduous Teeth and their Promise as
Preventive and Therapeutic Strategies for Neurological Diseases and Injuries
Authors: Huang Lingyi , Zheng Zizhuo , Bai Ding , Han Xianglong 
Published: December 2021

Abstract:
Stem cells from human exfoliated deciduous teeth (SHEDs) are relatively easy to isolate
from exfoliated deciduous teeth, which are obtained via dental therapy as biological waste. SHEDs
originate from the embryonic neural crest, and therefore, have considerable potential for neurogenic
differentiation. Currently, an increasing amount of research is focused on the therapeutic applications
of SHEDs in neurological diseases and injuries. In this article, we summarize the biological
characteristics of SHEDs and the potential role of SHEDs and their derivatives, including conditioned
medium from SHEDs and the exosomes they secrete, in the prevention and treatment of neurological
diseases and injuries.