bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on the Effect of Ganoderic Acid A on  Nociceptive and Inflammatory Mice Models
Authors: Yu Haizhou , Tao Qiaojian , Zeng Xianjing , Zhou Jinfeng 
Published: December 2024

Background Inflammatory illnesses and severe tissue injuries are frequently accompanied by pain. A widespread global health issue that has a significant negative impact on people’s quality of life everywhere is inflammation and the pain it causes. Purpose In this study, we sought to evaluate Ganoderic acid A’s antinociceptive and anti-inflammatory properties in mice models. Methods The current study aims to investigate the influence of Ganoderic acid A on animal models of inflammation and nociceptive response produced by heat and chemicals. Ganoderic acid A’s antinociceptive activity was examined using acetic acid-induced writhing, formalin and capsaicin-induced nociception, the tail immersion test, and the hot plate method. Ganoderic acid A’s anti-inflammatory effects were investigated utilizing carrageenan-induced inflammation, as well as the assessment of pro-inflammatory cytokine levels in mice. Additionally, the open-field test was used to examine behavioral changes in the mice. Results The findings of this work unequivocally showed that Ganoderic acid A significantly reduced the various thermally- and chemically-induced nociception in mice. Ganoderic acid A considerably increased the delay time in the hot plate and tail immersion tests. Capsaicin and formalin-stimulated models showed better licking times, and acetic acid-induced nociception was considerably reduced. Ganoderic acid A also effectively suppressed carrageenan-induced inflammation and decreased the synthesis of pro-inflammatory regulators including tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in the experimental animals. However, it demonstrated only minor improvements in the behavioral assessment. Conclusion Thus, these findings, when paired with future investigations, will provide a better knowledge of Ganoderic acid A’s antinociceptive and anti-inflammatory capabilities, allowing for the development of a novel analgesic drug. To corroborate the preclinical findings, however, rigorously planned clinical investigations are desperately needed.
Assessing the Anticancer Potential of Compounds from Caesalpinia sappan Wood against Mutant EGFR in Lung Squamous Cell Carcinoma: Computational Insights
Authors: Pashmina Shaik , Krishnasamy Nitya , Selvam Suganya Panneer , Ramadoss Ramya , Sundar Sandhya 
Published: December 2024

Background Lung squamous cell carcinoma (LUSC), a subtype of non-small cell lung cancer (NSCLC), frequently harbors mutations in the epidermal growth factor receptor (EGFR), which regulates cell proliferation and survival. This makes EGFR an attractive therapeutic target for LUSC. Advances in computational drug discovery have facilitated the identification of natural compounds with anticancer potential. Caesalpinia sappan, a medicinal plant with known therapeutic properties, contains bioactive phytochemicals that may exhibit anticancer effects. Purpose The purpose of the study is to assess the anticancer potential of phytochemicals from C. sappan against mutant EGFR in LUSC through computational approach, including molecular docking and biological activity prediction. Methods Thirty phytochemicals from C. sappan were retrieved from the Indian Medicinal Plants, Phytochemistry, and Therapeutics (IMPPAT) database. Drug-likeness was assessed using Lipinski’s rule of five, and ADMET properties were evaluated using the SwissADME web server. Compounds permeable to the blood-brain barrier (BBB) were excluded to mitigate central nervous system (CNS)-related side effects, resulting in the selection of 10 compounds for molecular docking with mutant EGFR using PyRx software. Docking scores were compared with doxorubicin, a standard anticancer drug. Biological activity prediction was performed using the PASS web server. Results Of the 30 phytochemicals screened, 24 adhered to Lipinski’s rule of five, and 14 were excluded due to BBB permeability. Molecular docking revealed that nine compounds had significant binding affinity toward mutant EGFR, with binding energies comparable to doxorubicin. Among these, norvaline exhibited the lowest binding affinity (–4.8 kcal/mol). Biological activity prediction indicated that eight of the nine lead compounds displayed antineoplastic activity, with oleic acid being the exception. Conclusion This study identified several phytochemicals from C. sappan with the potential to inhibit mutant EGFR in LUSC. The exclusion of BBB-permeant compounds enhances the clinical relevance of these findings by minimizing CNS-related side effects. These results underscore the promise of natural compounds as alternative therapeutic agents for targeting EGFR in LUSC and warrant further in vitro and in vivo validation.
Comparative analysis of Kirschner wire configurations for fixation of extra-articular proximal hallux fractures: Insights from synthetic composite bone models
Authors: Kocak Soner , Kilic Bulent , Caliskan Mustafa , Afacan Muhammed Yusuf , Uzun Bora , Ertem Fatih , Gulabi Deniz , Erturk Cemil 
Published: December 2024

Purpose: This study compares the durability and stability of Kirschner wires used in two different configurations for the fixation of extra-articular fractures of the proximal hallux. Methods: Standardized and reproducible extra-articular osteotomy lines were fixed with Kirschner wires arranged in cross and parallel configurations using synthetic composite bone models. These fixed composite bones were assessed under two distinct experimental setups. Measurements recorded included the load causing 2 mm displacement at the osteotomy line, load-to-failure, displacement at failure, and stiffness values. Results: In both experimental setups, the load causing 2 mm displacement, load-to-failure, and failure stiffness values were significantly higher for the cross configuration compared to the parallel configuration. Conversely, the displacement at failure was significantly lower in the cross configuration relative to the parallel configuration. Additionally, the force required to induce a 2 mm displacement in the cross-configuration group exceeded the force exerted on the hallux during normal walking. Conclusion: The results indicate that Kirschner wires applied in a cross configuration offer superior stability and durability for the fixation of proximal hallux fractures compared to the parallel configuration in synthetic composite bone models. To validate these findings and assess clinical outcomes, further research through a prospective randomized controlled trial is recommended.
Single-Incision Peroneal Tendon Repair With Concomitant Modified Dwyer Calcaneal Osteotomy: Report of 15 Cases With Plate Fixation
Authors: Saxena Amol , Fournier Maggie 
Published: December 2024

Background: Addressing hindfoot varus via calcaneal osteotomy with simultaneous peroneal tendon repair from a single incision has not been thoroughly assessed. Some concerns with one incision are wound complications, nerve damage, and symptomatic hardware. Methods: Patients operated on by one surgeon May 2012 to January 2022 were retrospectively reviewed with minimum 2-year follow-up via in-person visit, telephone, and chart review. Patients with peroneal tendon repair in conjunction with a modified Dwyer (with lateral shift) osteotomy fixated with a laterally applied locking plate were included. Those whose osteotomies were fixated with posteriorly applied screws were excluded. Results: Fifteen patients were assessed, 13 males and 2 females, average age 56.9 ± 9.9 years. There were no wound complications or nerve injuries. One patient elected to have plate removal. There was 1 deep vein thrombosis. Return to activity including sports was 5.3 ± 1.3 months. On average, postoperative Roles and Maudsley and AOFAS hindfoot scores improved to “significant from pre-treatment” 11 with “excellent” results. Conclusion: Peroneal tendon repair can be performed through the same incision as a modified Dwyer calcaneal osteotomy to address hindfoot varus deformity. In this series, there were no wound or nerve issues.
Cytotoxic surface contamination in hospitals: Current practices, challenges and perspectives
Authors: Favier Bertrand , Simonin Claire , Tokatian Sophie , Guitton Jérôme , Darnis Sophie , Basset Mathurine , Chabaud Sylvie , Gilles Laurence 
Published: December 2024

Objective Despite significant advances in cancer treatment with targeted therapies and immunotherapies, cytotoxic chemotherapies are still extensively used. Potential cytotoxic contamination in preparing and administrating cytotoxics is still a major source of concern. Besides advanced protections including biological safety cabinets, work surface contamination needs to be continuously controlled to ensure that handling procedures and cleaning were appropriate. Contamination monitoring needs to be standardized. Data Sources The study searched Pubmed/Medline and Embase with"hazardous drug”, “cytotoxic drug”, “surface contamination”, “environmental contamination”, “wipe sample”, “pharmacy”, “care unit”, and selected studies reporting contamination results in work environment for pharmacy technicians and nurses, from 1 January 2017 to 31 December 2022. Data Summary The 29 studies totalized 16,196 samples and 189,571 assays. Contamination results showed 39.8% sample positivity, and 8.2% assay positivity. Multicentric studies gathering at least 500 samples or up to 800 samples would limit heterogeneity in sample positivity. In addition, monitoring of an appropriate tracer selection including at least the 7 tracers with the highest contamination frequencies (cyclophosphamide, gemcitabine, fluorouracile, ifosfamide, platinum derivatives, paclitaxel and methotrexate) would facilitate contamination comparisons amongst studies and local results. Most recent studies reported thresholds for cyclophosphamide close to 0.1 ng/cm² at the 90th percentile. Conclusions The overall risk of exposure for healthcare professionals is a major concern. Sample size in multicentric studies would require at least 500 samples; quantification of all tracers with the highest contamination frequencies need to be quantified. This approach would provide a basis to develop guidelines to appropriately monitor contamination in pharmacies and patient care area managers.
Feline caudal vena cava to aorta ratio reference interval
Authors: Whitelock Adam , Goodwin Wendy , Pratt Shaun , Nash Katherine 
Published: December 2024

Objectives The primary objective of this investigation was to ultrasonographically evaluate the caudal vena cava to aorta (CVC:Ao) ratio in healthy, conscious cats and to generate reference intervals. A secondary objective was to identify the site of examination with the least intra- and inter-observer variability. This investigation was undertaken to assess whether the CVC:Ao ratio holds promise as a technique to assess intravascular volume responsiveness in cats. Methods In total, 42 healthy cats were included for reference interval generation. Ultrasound examinations were performed by two operators with each examination performed twice by each operator on the same occasion. Examinations were performed on conscious cats in left lateral recumbency. Ultrasound sites investigated were the subxiphoid, hepatic intercostal, hepatorenal and iliac bifurcation. Operators also assessed each site for ‘ease of visualisation’ on a scale of 0–3. Results Reference intervals were generated for the CVC:Ao ratio at all four ultrasonographic sites. While each site demonstrated low variability around its mean ratio, all sites exhibited significant intra- and inter-observer variability. The hepatorenal and iliac bifurcation sites were found to be the easiest to visualise (score 3; well-defined visualisation of both vessels) and had reference intervals of 0.8–1.41 and 0.75–1.2, respectively. Conclusions and relevance The ultrasonographic assessment of the CVC:Ao ratio was possible at four anatomical locations in the cat. The hepatorenal and iliac bifurcation may offer more readily assessable CVC:Ao ratios. Further studies are necessary to assess the utility of the CVC:Ao ratio in disease states, including in hypovolaemia and hypervolaemia.
Identifying the unique determinants influencing rural families’ engagement with an existing tele-assessment approach for autism identification: A qualitative study
Authors: Wagner Liliana , Foster Tori , Bonnet Kemberlee , Spitler Anna Kathleen , Schlundt David , Warren Zachary 
Published: December 2024

Accurate identification of autism is a pressing challenge for rural, medically underserved communities. Tele-assessment could address some barriers to care by increasing access to expert diagnosticians, but questions remain regarding how best to implement these approaches. To gather community input regarding rural families’ perceptions and use of tele-assessment for autism identification, we conducted four focus groups with caregivers of children with autism ( n = 22) and community service providers ( n = 10) living and working in rural areas in the Southeast region of the United States. An iterative inductive/deductive approach guided qualitative data analysis. Coding reflected four core attitudes central to community perceptions, including (1) questions surrounding the validity (scientific legitimacy) of tele-mediated autism assessment; (2) level of trust in the evaluation process in general (and tele-assessment specifically); (3) beliefs about the feasibility of tele-assessment; and (4) concerns related to privacy. These attitudes and beliefs are influenced by determinants at multiple levels and stages, highlighting the need to adapt the existing tele-assessment approach by embedding implementation strategies that support multiple actors at each stage. This work identifies important targets for ensuring equitable access to tele-assessment for rural families. Lay abstract It is often difficult for families in rural communities to access autism evaluations for their children when they have concerns. Tele-assessment could make it easier for them to see specialists who give autism diagnoses, but we still need to figure out the best way to carry out these approaches. To understand how rural families view tele-assessment, as well as barriers they may face, we held focus groups with caregivers of children with autism and local service providers in the Southeastern United States. We met with 22 caregivers and 10 providers. We analyzed the discussions and found four key attitudes: (1) questions about whether autism assessment can really be done online; (2) level of trust in the evaluation process, especially tele-assessment; (3) beliefs about whether tele-assessment is practical for families; and (4) worries about privacy. These attitudes and beliefs are shaped by various factors at different stages, indicating that we need to improve tele-assessment by better supporting everyone involved at different stages of the tele-assessment process. This research highlights important areas for improvement to provide fair access to tele-assessment for rural families (e.g. creating education materials, conducting barrier counseling).
Chinese Medicines Treatment for Sleep Disturbance in Breast Cancer Survivors: A Network Meta-Analysis
Authors: Chuang Chia-Wen , Tsai Ming-Yen , Wu Shih-Chung , Liao Wen-Chun 
Published: December 2024

Background: Sleep disturbance and insomnia are common adverse events in patients with breast cancer (BC). Traditional Chinese Medicine (TCM) treatment for sleep disturbance includes acupuncture, acupressure, auricular acupressure/auricular acupuncture, and Qigong. However, the specific efficacy of these TCM treatment remains unclear. Materials and Methods: This systematic review and network meta-analysis (NMA) investigated the effects of various TCM treatment on improving sleep quality in BC survivors. Methods: Only randomized controlled trials (RCTs) reporting the results of TCM treatments were included. The main NMA included 12 RCTs involving 1011 participants. The risk of bias was assessed using the RoB 2 tool for randomized controlled trials. The certainty of evidence of the NMA was assessed in accordance with GRADE (the Grading of Recommendations, Assessment, Development, and Evaluations). Results: Acupressure, acupuncture, auricular acupuncture/auricular acupressure, and qigong were identified as optimal TCM treatment (P < .05) for enhancing sleep quality in BC survivors. Conclusion: Our results provide some evidence that TCM treatment, particularly acupressure, can be beneficial in improving sleep quality in BC survivors. However, larger-scale clinical trials with robust methodological designs are required to validate and extend our findings.
Mapping social landscapes: Youth NEET risk and social issues in Europe – A systematic literature review
Authors: Lindblad Victoria , Enemark Nanna Ramsing , Gaardsted Pernille Skou , Møller Hansen Line Elise , Lauritzen Fie Falk , Melgaard Dorte 
Published: December 2024

Introduction The 40 million young people’s lack of successful transition from the education system to the labour market across Europe has a major focus. This systematic review of literature document social risk factors associated with NEET status in Europe. Methods A systematic literature search was conducted in four databases on February 21, 2023, with an update on January 15, 2024. Results A total of 98 articles included. Multiple social risk factors were associated with NEET status and divided into three spheres: factors related to the parental influence, the environment circumstance, and the individual factors. Conclusions Lacking a robust sense of self and limited self-efficacy, growing up in unstable home environment, having parents with low educational or labour market attainment are associated with significantly increased risk of NEET. Performing or behaving poorly in school and risk behaviour such as crime and substance use are also correlated with NEET status.
Social cognition profile in early Huntington disease: Insight from neuropsychological assessment and structural neuroimaging
Authors: Caillaud Marie , Laisney Mickael , Bejanin Alexandre , Duclos Harmony , Scherer-Gagou Clarisse , Prundean Adriana , Bonneau Dominique , Eustache Francis , Verny Christophe , Desgranges Béatrice , Allain Philippe 
Published: December 2024

Background Huntington's disease (HD) is traditionally associated with motor, cognitive, and neuropsychiatric symptoms. Recent observations suggest that disturbances in social cognition may feature prominently in HD, potentially contributing to behavioral challenges. Objective This study aims to explore the onset and neural mechanisms underlying social cognition disturbances in HD, which are not yet well understood despite increasing recognition of these symptoms. Methods This study compared 20 individuals in the early stages of HD with 20 healthy controls across a range of cognitive tests, in-depth social cognition assessments, and structural MRI evaluations. Results The findings revealed alterations in various aspects of social cognition, particularly cognitive and affective Theory of Mind, in the early HD group. Some of these alterations correlated with the neurodegeneration of the striatum (caudate), suggesting that social cognition deficits may serve as early indicators of disease progression. Conclusions This research underscores the importance of integrating social cognition evaluations into the clinical assessment of HD and hints at a complex interplay between these deficits and the broader neuropsychological impact of the disease. The results thus advocate for a more holistic approach to understanding and managing HD, considering the potential interdependencies between social cognition and other cognitive functions.
Prolonged Surveillance in Inverted Papilloma Reveals Delayed Recurrence and Lack of Benefit to Frozen Section
Authors: Panara Kush , Workman Alan D. , Lerner David K. , Tong Charles C. L. , Wilensky Jadyn , Douglas Jennifer E. , Adappa Nithin D. , Palmer James N. , Kohanski Michael A. 
Published: December 2024

Background To reduce recurrence rates of inverted papilloma (IP), some have argued for the use of intraoperative frozen margins; results remain mixed and studies critically lack lengthy surveillance periods. Objective We aim to elucidate the impact of prolonged surveillance and intraoperative frozen margins on IP recurrence. Methods This is a retrospective analysis of patients who underwent resection of IP at a tertiary care center over a 10-year period from 2008 to 2018 followed by subsequent surveillance. Patient demographics, tumor and operative characteristics, and recurrences were analyzed. Results Our analysis includes 199 patients, with 37 recurrences and an average recurrence time of 44.4 months; 57% of patients received intraoperative frozen sections and recurrence rates were similar between those who received frozen sections and those who did not (20.1% vs 15.5%, P = .36). Patients with recurrences within 5 years of surgery were more likely to have received frozen sections than those with recurrences beyond 5 years ( P < .01). There was no difference in surgical approach or extent of disease in those who received frozen margins. Patients that received frozen sections were more likely to have multiple sites of attachment (56.5% vs 38.1%, P = .01) and persistent disease following a previous resection at an outside institution (67.0% vs 44.0%, P = .001). Conclusion Our average time to recurrence was 44.4 months, significantly longer than surveillance times reported in the literature, indicating that longer periods of surveillance are necessary to capture late recurrences. Our analysis is the first and largest American cohort to look at IP resection in a standardized fashion and find that recurrence rates are similar between patients receiving frozen sections or not.