bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of hypokalemia in COVID-19 and its association with clinical and common laboratory parameters
Authors: Islam Md Khairul , Hasan Pratyay , Hossain Md Murad , Hossain Fahima Sharmin , Khan Tazdin Delwar , Ratul Rifat Hossain , Rahman Motlabur , Hossain Mohammad Zaid , Datta Ponkaj Kanti , Sharif Md Mohiuddin , Azad Khan Abul Kalam 
Published: March 2021

Importance: Hypokalemia is a neglected common manifestation in COVID-19 patients admitted in hospital though it has serious consequences. Coronavirus may cause hypokalemia through disruptions of rennin-angiotensin system, gastrointestinal loss or other unknown mechanisms.
Objective: To investigate the prevalence of hypokalemia among patients with moderate to severe COVID-19 and its association with other clinical and laboratory parameters.
Design, Setting, and Participants: This was cross sectional observational study conducted at Dhaka medical College Hospital of Bangladesh from June, 2020, to August 2020. Participants were included who were positive for rt-PCR for COVID-19 according to the national guideline. The patients were classified as having severe hypokalemia (plasma potassium <3 mmol/L), hypokalemia (plasma potassium 3-3.5 mmol/L), and normokalemia (plasma potassium >3.5 mmol/L).
Results: Prevalence of hypokalemia among patients with COVID-19 was 20.2%, severe hypokalemia (2 patients [1.5%]) and hypokalemia (25 patients [18.7%]). One thirty four (134) patients with positive COVID-19 were included. The mean [SD] age of these 134 patients according to different potassium levels appear to be : 68 [2.83] years for severe hypokalemia , 51.93[11.68] years for hypokalemia and 50.73[14.7] years for normokalemia. Among them, 46 patients were females [34.32%]) and rest were males [65.68%]. Within the total sum of 134 patients, 107 were identified having normokalemia, [79.9%]. 25 patients [18. 7%] had hypokalemia and only two patients [1.5%] were found having normokalemia. Among 134 patients, three commonest symptoms were fever (132 patients [98.5%]), dry cough (123 patients (91.79%) and shortness of breath (122 patients [91.04%]), followed by less common symptoms like fatigue (89 patients [66.410%]), sore throat (60 patients [44.77%]), and diarrhea (44 patients, [32.83%]). Shortness of breath was associated with grades of hypokalemia (P=0.022). Only 26 patients (19.4%) manifested having vomiting/Nausea. The predominant comorbidities found among these 134 participants were Hypertension (68 patients [64.2%]), Diabetes (54 patients [52.9%]), Ischemic heart disease (37 patients [38.1%]) and Asthma (27 patients [31.0%]). The prevalence of comorbidities was not associated with Hypokalemia.
Conclusions Prevalence of hypokalemia among patients with COVID-19 is high (20.2%) and appropriate treatment is highly required.
J Dhaka Medical College, Vol. 29, No.2, October, 2020, Page 131-137
Pregnancy outcome in covid-19 positive women in a covid dedicated hospital
Authors: Mustafa Fahmida Naz , Yasmin Nahid , Islam Munmun , Mehzabin Shafinaz , Siddique Sharmina , Alam Saleha 
Published: March 2021

Objective: To see the maternal and fetal outcome in covid positive hospitalized pregnant women.
Method: It is an observational study done in Mugda Medical College Hospital. Duration was from 23 April, 2020 to 16 June, 2020 .
Result : 32 hospitalisedcovid positive pregnant women were studied. 84.4% women were above 25 years and 78% were multigravid. 19% had fever on admission and 59% had H/O fever. 22% had respiratory distress ranging from mild to severe on admission. During the hospital stay 28.2% needed ICU. 57.9% women delivered before completion of 37 weeks, among them. 26.3% were before 34 weeks. 79% women had delivery by Cesarean section and 10.5% had hysterotomy. In this study maternal mortality was 21% and 31.6% was perinatal mortality. There was no vertical transmission to fetus.
Conclusion: During thisstudy , it is found that pregnancy outcome was not good in covid positive pregnant women . For the infected mothers early medical supervision and availability of ICU in critical condition is needed for better pregnancy outcome.
J Dhaka Medical College, Vol. 29, No.2, October, 2020, Page 153-157
Peningkatan Produktivitas Ramuan Herbal Di Kelurahan Gadel Kecamatan Tandes Kota Surabaya Dengan Penerapan Manajemen Produksi Administrasi Dan Pemasaran
Authors: Yanto Erwan Arist , Ermawati Yuli , Nanda Aditya Surya 
Published: March 2021

Ditengah merebaknya Covid â€“ 19 atau virus Corona berbagai produk herbal laris manis di pasaran tak terkecuali produk UMKMÂ minuman ramuan herbal tradisional ikut terdongkrak. Momentum ini harus di manfaat sebaik mungkin oleh pelaku usaha. Mitra kami adalah Ibu Sunarti yang lebih dikenal dengan panggilan Bu Yanto, berdomisili di Kelurahan Gadel, Kecamatan Tandes, Kota Surabaya. Beliau menitipkan ramuan herbalnya di toko â€“ toko kelontongÂ Â sekitar yang memiliki lemari pendingin. Karena keterbatasan ramuan herbal yang hanya menjual produk sinom, keterbatasan administrasi pembukuan, keterbatasan IPTEK dan permodalan membuat ibu Sunarti tidak berani memperluas pasar. Padahal semangat dan potensi produk ramuan herbal sangat menjanjikan. Solusi yang di berikan yang pertama yaitu dengan melakukan uji coba penambahan varian produk. Kedua, memberikan pendampingan dan pelatihan manajemen keuangan dan usaha, Ketiga, memberikan pendampingan dan pelatihan manajemen pemasaran, baik secara offline ( pelabelan, brosur, kartu nama dan konsinyasi ) maupun online ( sosial media, marketplace ) untuk meningkatkan jangkauan pasar. Metode yang di gunakan adalah pendampingan personal terhadap mitra. Rencana yang akan dilakukan oleh tim adalah dengan memberikan pelatihan untuk manajemen usaha mereka ( mulai dari proses pengelolaan produksi, pembukuan sederhana,Â pemasaran efektif dan inspirasi pengusaha sukses ) dengan mendatangkan para pakar yang kompeten untuk mendongkrak usaha mereka. Setelah itu tim akan mengawal mitra untuk membuat label yang modern dan menarik dengan merek yang mereka ciptakan. Kemudian mendampingi mitra dalam memasarkan produk secara offline dan online agar jangkauan pasar lebih luas. Dengan begitu diharapkan pendapatan dan kesejahteraan mitra akan meningkat.Â Â Â
Pelatihan Kejuruan Pengolahan Hasil Pertanian Balai Latihan Kerja Sorong
Authors: Zain Evi Mufrihah , Andjar Febry Jein , Devi Devi 
Published: March 2021

Penelitian ini bertujuan untuk mempelajari bagaimana caraÂ memanfaatkan sumberdaya alam untuk dihasilkan menjadi bahan pangan, mengolah bahan mentah menjadi berbagai macam produk yang bermanfaat dan untuk meningkatkan dampak perekonomian masyarakat, Penelitian iniÂ menggunakan beberapa metode pendekatan yaitu pelatihan dan penyuluhan yang dilakukan di Balai Latihan Kerja Sorong. Pada umumnya masyarakat selalu menginginkanÂ sesuatu yang berbeda, tidak terkecuali dengan hal kuliner atau makanan. Hasil olahan labu kuning dapat di olah menjadi beberapa makanan yaitu cake labu kuning , kue lumpur labu kuning , puding labu kuning ,karena di kota sorong sendiri pengolahan labu kuning biasanya hanya sebagai sayuran. Kesimpulannya melalui kegiatan pelatihan pengolahan labu kuning dapat menciptakan berbagai makanan yang mempunyai banyak varian yang dapat dikonsumsi. Â
Andrei Sakharov’s research work and modern physics
Authors: Altshuler B L 
Published: March 2021

AbstractWe follow the work carried out by Andrei Sakharov in both research and engineering, from the first domestic thermonuclear charges to fundamental physics. We emphasize the current status of the research fields recognized to have originated in Sakharov’s work: controlled fusion, magnetic cumulation and magnetic explosion generators, induced gravity, cosmological ‘Sakharov’ (baryonic acoustic) oscillations, and baryon asymmetry of the Universe. Another subject that unexpectedly gained momentum in the 21st century is the model of a pulsating universe, which was among Sakharov’s ideas. Other subjects that were dear to him, such as quantum cosmology and the anthropic principle, are also currently at the forefront of science.
PENGARUH EFIKASI DIRI, MOTIVASI BELAJAR DAN MINAT BACA TERHADAP HASIL BELAJAR SPEAKING SISWA KELAS X
Authors: Hardianti Novilia , Marpaung Marlin P. 
Published: March 2021

The use of English in communication becomes important nowadays in facing the challenges of globalization. Mainly in education, English is one of the school subjects that helps students in preparing their abilities to be part of global citizens. Speaking skills in English subject is one of way in preparing the students, meanwhile learn English also becomes one of the challenges for students.This research is is a quantitative research which aimed to identify the influence of self efficacy, learning motivation and reading interest of the students to their learning outcomes of speaking skill. Data collection was carried out by distributing 3 questionnaires to a population of grade X students, as well as doing some interview to grade X students. The data obtained were further processed and examined by conducting multiple regression analysis tests and determining contributions through R-Square values. The population in this research consists of 76 students. On the results of the analysis, self-efficacy had positive influence on learning outcomes of speaking. Learning motivation had positive influence on learning outcomes of speaking. The last, the coefficient of reading interest had positive influence of reading interest on speaking learning outcomes. These results are based on the R-Square value of the three variables silmutantly have a strong influence on learning outcomes of speaking skills.
Penggunaan bahasa Inggris dalam berkomunikasi dirasakan penting dalam menghadapai tantangan global sekarang ini. Terkhusus dalam dunia pendidikan, Bahasa Inggris menjadi salah satu matapelajaran yang membantu siswa sebagai bentuk persiapan untuk membekali kemampuan dan kecakapan siswa menjadi bagian dari warga global. Keterampilan berbicara “speaking skill” dalam bahasa Inggris juga menjadi salah satu tantangan bagi para sisw. Penelitian ini bersifat kuantitatif dengan tujuan untuk mengidentifikasi pengaruh efikasi diri, motivasi belajar dan minat baca terhadap hasil belajar speaking siswa. Pengumpulan data dilakukan dengan penyebaran tiga kuesioner kepada populasi siswa kelas X, pemberian pertanyaan wawancara kepada siswa kelas X, serta nilai hasil belajar speaking siswa. Data yang diperoleh selanjutnya dianalisis dengan melakukan analisis regresi berganda serta menentukan kontribusi melalui nilai R-Square. Populasi siswa terdiri dari 76 siswa. Berdasarkan hasil analisis yang diperoleh yakni bahwa koefisien efikasi diri berpengaruh positif terhadap hasil belajar speaking. Koefisien motivasi belajar berpengaruh positif terhadap hasil belajar speaking. Terakhir yakni koefisien minat baca berpengaruh positif minat baca terhadap hasil belajar speaking. Berdasarkan nilai R-Square, maka ketiga variabel diatas diperoleh nilai secara simultan berpengaruh kuat terhadap hasil belajar speaking.
Impacts of the Wetland Environment on Demographic Development During the Neolithic in the Lower Yangtze Region—Based on Peat and Archaeological Dates
Authors: Shao Konglan , Zhang Jianping , He Keyang , Wang Can , Lu Houyuan 
Published: March 2021

Wetlands were important resources for the hunting–gathering and early farming communities in coastal areas in the Neolithic. However, the relationship between the development of the wetland environment and the human population remains unclear due to the lack of successive wetland environmental changes throughout the Holocene in coastal areas. Here, the summed probability distributions (SPD) of radiocarbon dates of peat were used as an indicator and combined with archaeological radiocarbon dates to reconstruct the wetland environmental and demographic changes during the Neolithic in the lower Yangtze region. The results showed that the shifts in demographic centers and population development were related to wetland environment with peat formation. The first shift of the demographic center was from the hilly regions to the coastal plain and occurred during ca. 8,300–8,000 cal yr BP, which might be caused by the attractiveness of survival resources offered by the coastal wetland environment and the 8.2 ka event. The second shift occurred from the Ningshao Plain to the Taihu region and might be attributed to the widespread waterlogged environment in the Ningshao Plain. The peak of demographic development coincided with the peak of peat formation during the middle Holocene in the lower Yangtze region, indicating that the wetland environment facilitated changes in human societies. The formation of peat might be related to the sea-level and El Niño-Southern Oscillation events; however, further studies are required for deep comprehension. The present study is an attempt at identifying the past impacts of the wetland environment on demographic development and can form the basis for a more comprehensive understanding of the interactions between the humans and their living environment.
Identification and Analysis of Potential Key Genes Associated With Hepatocellular Carcinoma Based on Integrated Bioinformatics Methods
Authors: Li Zhuolin , Lin Yao , Cheng Bizhen , Zhang Qiaoxin , Cai Yingmu 
Published: March 2021

BackgroundHepatocellular carcinoma (HCC) is a type of primary liver tumor with poor prognosis and high mortality, and its molecular mechanism remains incompletely understood. This study aimed to use bioinformatics technology to identify differentially expressed genes (DEGs) in HCC pathogenesis, hoping to identify novel biomarkers or potential therapeutic targets for HCC research.MethodsThe bioinformatics analysis of our research mostly involved the following two datasets: Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). First, we screened DEGs based on the R packages (limma and edgeR). Using the DAVID database, the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs were carried out. Next, the protein-protein interaction (PPI) network of the DEGs was built in the STRING database. Then, hub genes were screened through the cytoHubba plug-in, followed by verification using the GEPIA and Oncomine databases. We demonstrated differences in levels of the protein in hub genes using the Human Protein Atlas (HPA) database. Finally, the hub genes prognostic values were analyzed by the GEPIA database. Additionally, using the Comparative Toxicogenomics Database (CTD), we constructed the drug-gene interaction network.ResultsWe ended up with 763 DEGs, including 247 upregulated and 516 downregulated DEGs, that were mainly enriched in the epoxygenase P450 pathway, oxidation-reduction process, and metabolism-related pathways. Through the constructed PPI network, it can be concluded that the P53 signaling pathway and the cell cycle are the most obvious in module analysis. From the PPI, we filtered out eight hub genes, and these genes were significantly upregulated in HCC samples, findings consistent with the expression validation results. Additionally, survival analysis showed that high level gene expression of CDC20, CDK1, MAD2L1, BUB1, BUB1B, CCNB1, and CCNA2 were connected with the poor overall survival of HCC patients. Toxicogenomics analysis showed that only topotecan, oxaliplatin, and azathioprine could reduce the gene expression levels of all seven hub genes.ConclusionThe present study screened out the key genes and pathways that were related to HCC pathogenesis, which could provide new insight for the future molecularly targeted therapy and prognosis evaluation of HCC.
Fluorescence-Guided High-Grade Glioma Surgery More Than Four Hours After 5-Aminolevulinic Acid Administration
Authors: Maragkos Georgios A. , Schüpper Alexander J. , Lakomkin Nikita , Sideras Panagiotis , Price Gabrielle , Baron Rebecca , Hamilton Travis , Haider Sameah , Lee Ian Y. , Hadjipanayis Constantinos G. , Robin Adam M. 
Published: March 2021

Background: Fluorescence-guided surgery (FGS) using 5-aminolevulic acid (5-ALA) is a widely used strategy for delineating tumor tissue from surrounding brain intraoperatively during high-grade glioma (HGG) resection. 5-ALA reaches peak plasma levels ~4 h after oral administration and is currently approved by the FDA for use 2–4 h prior to induction to anesthesia.Objective: To demonstrate that there is adequate intraoperative fluorescence in cases undergoing surgery more than 4 h after 5-ALA administration and compare survival and radiological recurrence to previous data.Methods: Retrospective analysis of HGG patients undergoing FGS more than 4 h after 5-ALA administration was performed at two institutions. Clinical, operative, and radiographic pre- and post-operative characteristics are presented.Results: Sixteen patients were identified, 6 of them female (37.5%), with mean (SD) age of 59.3 ± 11.5 years. Preoperative mean modified Rankin score (mRS) was 2 ± 1. All patients were dosed with 20 mg/kg 5-ALA the morning of surgery. Mean time to anesthesia induction was 425 ± 334 min. All cases had adequate intraoperative fluorescence. Eloquent cortex was involved in 12 cases (75%), and 13 cases (81.3%) had residual contrast enhancement on postoperative MRI. Mean progression-free survival was 5 ± 3 months. In the study period, 6 patients died (37.5%), mean mRS was 2.3 ± 1.3, Karnofsky score 71.9 ± 22.1, and NIHSS 3.9 ± 2.4.Conclusion: Here we demonstrate that 5-ALA-guided HGG resection can be performed safely more than 4 h after administration, with clinical results largely similar to previous reports. Relaxation of timing restrictions could improve procedure workflow in busy neurosurgical centers, without additional risk to patients.
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma
Authors: Wang Li , Wu Jian , Song Shu , Chen Haining , Hu Yong , Xu Buwei , Liu Jinbo 
Published: March 2021

BackgroundThe exosomes contain many important proteins that can be used for early tumor diagnosis or patient prognosis analysis. In this study, we investigated plasma exosome-derived sentrin SUMO-specific protease 1 (SENP1) levels as a prognostic biomarker in patients with osteosarcoma.MethodsThe expression of SENP1 protein in osteosarcoma tissues and adjacent tissues was detected by immunohistochemistry (IHC). The exosomes were identified by transmission electron microscopy, nanoparticle tracking analysis, and western blotting. ELISA was used to detect plasma exosome-derived SENP1 levels to assess prognosis in patients with osteosarcoma.ResultsIHC showed that the positive expression rate of SENP1 in osteosarcoma tissues was 88.33%, whereas that in adjacent tissues was 46.67% (P &lt; 0.05). Plasma exosome-derived SENP1 levels were related to tumor size, tumor location, necrosis rate, pulmonary metastasis, and surgical stage. Both disease-free survival (DFS) and overall survival (OS) were worse in patients who had higher plasma exosome-derived SENP1 levels compared with those in patients with lower plasma exosome-derived SENP1 levels (P &lt; 0.001). The area under the receiver operating characteristic curve (AUROC) of plasma exosome-derived SENP1, as 1-year DFS and 3-year DFS prognostic biomarkers, was 0.90 (95% CI: 0.83–0.98) and 0.96 (95% CI: 0.94–0.99), respectively. As to OS, the AUROC of plasma exosome-derived SENP1 for 1-year and 3-year prediction was 0.90 (95% CI: 0.82–0.99) and 0.96 (0.93–0.98), respectively. The plasma exosome-derived SENP1 was better than plasma SENP1 as a prognostic biomarker both in DFS and OS.ConclusionsOur findings show that the plasma exosome-derived SENP1 may serve as a novel and independent prognostic predictor in clinical applications.
Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets
Authors: Zhong Xiaodan , Tao Ying , Chang Jian , Zhang Yutong , Zhang Hao , Wang Linyu , Liu Yuanning 
Published: March 2021

BackgroundThe prognostic value of immune-related genes and lncRNAs in neuroblastoma has not been elucidated, especially in subgroups with different outcomes. This study aimed to explore immune-related prognostic signatures.Materials and MethodsImmune-related prognostic genes and lncRNAs were identified by univariate Cox regression analysis in the training set. The top 20 C-index genes and 17 immune-related lncRNAs were included in prognostic model construction, and random forest and the Least Absolute Shrinkage and Selection Operator (LASSO) regression algorithms were employed to select features. The risk score model was constructed and assessed using the Kaplan-Meier plot and the receiver operating characteristic curve. Functional enrichment analysis of the immune-related lncRNAs was conducted using the STRING database.ResultsIn GSE49710, five immune genes (CDK4, PIK3R1, THRA, MAP2K2, and ULBP2) were included in the risk score five genes (RS5_G) signature, and eleven immune-related lncRNAs (LINC00260, FAM13A1OS, AGPAT4-IT1, DUBR, MIAT, TSC22D1-AS1, DANCR, MIR137HG, ERC2-IT1, LINC01184, LINC00667) were brought into risk score LncRNAs (RS_Lnc) signature. Patients were divided into high/low-risk score groups by the median. Overall survival and event/progression-free survival time were shortened in patients with high scores, both in training and validation cohorts. The same results were found in subgroups. In grouping ability assessment, the area under the curves (AUCs) in distinguishing different groups ranged from 0.737 to 0.94, better in discriminating MYCN status and high risk in training cohort (higher than 0.9). Multivariate Cox analysis demonstrated that RS5_G and RS_Lnc were the independent risk factors for overall and event/progression-free survival (all p-values &lt;0.001). Correlation analysis showed that RS5_G and RS_Lnc were negatively associated with aDC, CD8+ T cells, but positively correlated with Th2 cells. Functional enrichment analyzes demonstrated that immune-related lncRNAs are mainly enriched in cancer-related pathways and immune-related pathways.ConclusionWe identified the immune-related prognostic signature RS5_G and RS_Lnc. The predicting and grouping ability is close to being even better than those reported in other studies, especially in subgroups. This study provided prognostic signatures that may help clinicians to choose optimal treatment strategies and showed a new insight for NB treatment. These results need further biological experiments and clinical validation.