bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic health, menopause, and physical activity—a 4-year follow-up study
Authors: Hyvärinen Matti , Juppi Hanna-Kaarina , Taskinen Sara , Karppinen Jari E. , Karvinen Sira , Tammelin Tuija H. , Kovanen Vuokko , Aukee Pauliina , Kujala Urho M. , Rantalainen Timo , Sipilä Sarianna , Laakkonen Eija K. 
Published: November 2021

Abstract
Background
In women, metabolic health deteriorates after menopause, and the role of physical activity (PA) in mitigating the change is not completely understood. This study investigates the changes in indicators of metabolic health around menopause and evaluates whether PA modulates these changes.

Methods
Longitudinal data of 298 women aged 48–55 years at baseline participating in the ERMA and EsmiRs studies was used. Mean follow-up time was 3.8 (SD 0.1) years. Studied indicators of metabolic health were total and android fat mass, waist circumference, waist-to-hip ratio (WHR), systolic (SBP) and diastolic (DBP) blood pressure, blood glucose, triglycerides, serum total cholesterol, and high- (HDL-C) and low-density (LDL-C) lipoprotein cholesterol. PA was assessed by accelerometers and questionnaires. The participants were categorized into three menopausal groups: PRE-PRE (pre- or perimenopausal at both timepoints, n = 56), PRE-POST (pre- or perimenopausal at baseline, postmenopausal at follow-up, n = 149), and POST-POST (postmenopausal at both timepoints, n = 93). Analyses were carried out using linear and Poisson mixed-effect models.

Results
At baseline, PA associated directly with HDL-C and inversely with LDL-C and all body adiposity variables. An increase was observed in total (B = 1.72, 95% CI [0.16, 3.28]) and android fat mass (0.26, [0.06, 0.46]), SBP (9.37, [3.34, 15.39]), and in all blood-based biomarkers in the PRE-POST group during the follow-up. The increase tended to be smaller in the PRE-PRE and POST-POST groups compared to the PRE-POST group, except for SBP. The change in PA associated inversely with the change in SBP (−2.40, [−4.34, −0.46]) and directly with the change in WHR (0.72, [0.05, 1.38]).

Conclusions
In middle-aged women, menopause may accelerate the changes in multiple indicators of metabolic health. PA associates with healthier blood lipid profile and body composition in middle-aged women but does not seem to modulate the changes in most of the studied metabolic health indicators during the menopausal transition.
Photoheterotrophy by aerobic anoxygenic bacteria modulates carbon fluxes in a freshwater lake
Authors: Piwosz Kasia , Villena-Alemany Cristian , Mujakić Izabela 
Published: November 2021

Abstract
Lakes are a significant component of the global carbon cycle. Respiration exceeds net primary production in most freshwater lakes, making them a source of CO2 to the atmosphere. Driven by heterotrophic microorganisms, respiration is assumed to be unaffected by light, thus it is measured in the dark. However, photoheterotrophs, such as aerobic anoxygenic photoheterotrophic (AAP) bacteria that produce ATP via photochemical reactions, substantially reduce respiration in the light. They are an abundant and active component of bacterioplankton, but their photoheterotrophic contribution to microbial community metabolism remains unquantified. We showed that the community respiration rate in a freshwater lake was reduced by 15.2% (95% confidence interval (CI): 6.6–23.8%) in infrared light that is usable by AAP bacteria but not by primary producers. Moreover, significantly higher assimilation rates of glucose (18.1%; 7.8–28.4%), pyruvate (9.5%; 4.2–14.8%), and leucine (5.9%; 0.1–11.6%) were measured in infrared light. At the ecosystem scale, the amount of CO2 from respiration unbalanced by net primary production was by 3.69 × 109 g CO2 lower over these two sampling seasons when measured in the infrared light. Our results demonstrate that dark measurements of microbial activity significantly bias the carbon fluxes, providing a new paradigm for their quantification in aquatic environments.
Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients
Authors: Gasparetto Cristina , Schiller Gary J. , Tuchman Sascha A. , Callander Natalie S. , Baljevic Muhamed , Lentzsch Suzanne , Rossi Adriana C. , Kotb Rami , White Darrell , Bahlis Nizar J. , Chen Christine I. , Sutherland Heather J. , Madan Sumit , LeBlanc Richard , Sebag Michael , Venner Christopher P. , Bensinger William I. , Biran Noa , Ammu Sonia , Ben-Shahar Osnat , DeCastro Andrew , Van Domelen Dane , Zhou Tianjun , Zhang Chris , Bentur Ohad S. , Shah Jatin , Shacham Sharon , Kauffman Michael , Lipe Brea 
Published: November 2021

Abstract
Background
Proteasome inhibitors (PIs), including carfilzomib, potentiate the activity of selinexor, a novel, first-in-class, oral selective inhibitor of nuclear export (SINE) compound, in preclinical models of multiple myeloma (MM).

Methods
The safety, efficacy, maximum-tolerated dose (MTD) and recommended phase 2 dose (RP2D) of selinexor (80 or 100 mg) + carfilzomib (56 or 70 mg/m2) + dexamethasone (40 mg) (XKd) once weekly (QW) was evaluated in patients with relapsed refractory MM (RRMM) not refractory to carfilzomib.

Results
Thirty-two patients, median prior therapies 4 (range, 1–8), were enrolled. MM was triple-class refractory in 38% of patients and 53% of patients had high-risk cytogenetics del(17p), t(4;14), t(14;16) and/or gain 1q. Common treatment-related adverse events (all/Grade 3) were thrombocytopenia 72%/47% (G3 and G4), nausea 72%/6%, anaemia 53%/19% and fatigue 53%/9%, all expected and manageable with supportive care and dose modifications. MTD and RP2D were identified as selinexor 80 mg, carfilzomib 56 mg/m2, and dexamethasone 40 mg, all QW. The overall response rate was 78% including 14 (44%) ≥ very good partial responses. Median progression-free survival was 15 months.

Conclusions
Weekly XKd is highly effective and well-tolerated. These data support further investigation of XKd in patients with MM.
Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast
Authors: Lv Jianke , Shi Qianqian , Han Yunwei , Li Weidong , Liu Hanjiao , Zhang Jingyue , Niu Chen , Gao Guangshen , Fu Yiru , Zhi Renyong , Wu Kailiang , Li Shuai , Gu Feng , Fu Li 
Published: November 2021

AbstractInvasive micropapillary carcinoma (IMPC) is a special histological subtype of breast cancer, featured with extremely high rates of lymphovascular invasion and lymph node metastasis. Based on a previous series of studies, our team proposed the hypothesis of “clustered metastasis of IMPC tumor cells”. However, the transcriptomics characteristics underlying its metastasis are unknown, especially in spatial transcriptomics (ST). In this paper, we perform ST sequencing on four freshly frozen IMPC samples. We draw the transcriptomic maps of IMPC for the first time and reveal its extensive heterogeneity, associated with metabolic reprogramming. We also find that IMPC subpopulations with abnormal metabolism are arranged in different spatial areas, and higher levels of lipid metabolism are observed in all IMPC hierarchical clusters. Moreover, we find that the stromal regions show varieties of gene expression programs, and this difference depends on their distance from IMPC regions. Furthermore, a total of seven IMPC hierarchical clusters of four samples share a common higher expression level of the SREBF1 gene. Immunohistochemistry results further show that high SREBF1 protein expression is associated with lymph node metastasis and poor survival in IMPC patients. Together, these findings provide a valuable resource for exploring the inter- and intra-tumoral heterogeneity of IMPC and identify a new marker, SREBF1, which may facilitate accurate diagnosis and treatment of this disease.
Dense SnS2 nanoplates vertically anchored on a graphene aerogel for pseudocapacitive sodium storage
Authors: Guo Xin , Wang Shuai , Yu Linpeng , Guo Chunyu , Yan Peiguang , Gao Hong , Liu Hao 
Published: November 2021

A 2D heterostructure with dense SnS2 nanoplates vertically anchored on a graphene aerogel (SnS2@GA) was achieved via a controlled self-assembly process followed by a thermally induced sulfidation treatment for high-performance sodium-ion batteries.
Effect of chemical corrosion on charge transport behaviour in epoxy/Al2O3 nanocomposite irradiated by gamma ray
Authors: Gao Yu , Li Jing , Xu Bangbang , Ye Binyuan , Du Boxue 
Published: November 2021

AbstractChemical corrosion and gamma‐ray irradiation appeared with the loss of coolant accident may seriously threaten the safe operation of a nuclear power plant, where epoxy resin (ER)‐based materials are widely used. It is urgent to study the effects of the corrosion and the irradiation on the electrical performance in an ER‐based nanocomposite. In this work, ER/Al2O3 nanocomposite samples with 0, 1, 3, 5‐wt% nano Al2O3 filler content were prepared at the thickness of 2 mm, and the total gamma irradiation dose was 0, 500, and 1000 kGy. The samples were chemically corroded in a boric acid solution (pH = 4.7) and a trisodium phosphate alkaline solution (pH = 11) at 60°C and 100°C for 48 h. Charge transport behaviour in the samples was derived from the surface potential decay method. In addition, the sample structures were characterised to analyse the corrosion mechanism in the solutions. The results indicated that the depth and the density of the trap showed a temperature‐dependent manner associated with the corrosion. With the addition of appropriate content of the filler, the trap centre was deepened and the carrier mobility was limited even after the corrosion. It is found that the appearance of hydroxyl and carboxyl groups during corrosion, the interaction between the nanoparticle and the matrix and the crosslinking reaction caused by the irradiation are responsible for the variation in charge transport behaviour.
Augmented global attention network for image super‐resolution
Authors: Du Xiaobiao , Jiang Saibiao , Liu Jie 
Published: November 2021

AbstractConvolutional networks dominate many machine vision fields. Nevertheless, a significant drawback of the convolution operation is that it only operates in the local region, so it lacks global information. Self‐attention has become the latest technology for capturing long‐range interactions, but it is mainly used for generative modeling and sequence modeling tasks. Using self‐attention to tackle super‐resolution as a substitute for convolution is considered. Therefore, augmented global attention convolution (AGAC) is proposed as an alternative to convolution to use self‐attention for super‐resolution. The proposed augmented global attention convolution can capture global context to produce more realistic super‐resolution results. Due to the most existing works that have not exploited position information, a two‐dimensional relative self‐attention mechanism is proposed to enhance self‐attention. To deal with the super‐resolution task, the authors come up with an augmented global attention convolutional network (AGAN) to enhance the convolution operator with the self‐attention mechanism through concatenating the convolution pattern map with the generated set of feature maps. Many experiments and analyses are conducted to demonstrate that the proposed model surpasses the advanced models with comparable parameters and performance.
ProbingKepler’s hottest small planets via homogeneous search and analysis of optical secondary eclipses and phase variations
Authors: Singh V. , Bonomo A. S. , Scandariato G. , Cibrario N. , Barbato D. , Fossati L. , Pagano I. , Sozzetti A. 
Published: November 2021

Context.High-precision photometry can lead to the detection of secondary eclipses and phase variations of highly irradiated planets.Aims.We performed a homogeneous search and analysis of optical occultations and phase variations of the most favorable ultra-short-period (USP) (P< 1 days) sub-Neptunes (Rp< 4R⊕), observed byKeplerand K2, with the aim to better understand their nature.Methods.We first selected 16Keplerand K2 USP sub-Neptunes based on the expected occultation signal. We filtered out stellar variability in theKeplerlight curves, using a sliding linear fitting and, when required, a more sophisticated approach based on a Gaussian process regression. In the case of the detection of secondary eclipse or phase variation with a confidence level higher than 2σ, we simultaneously modeled the primary transit, secondary eclipse, and phase variations in a Bayesian framework, by using information from previous studies and knowledge of theGaiaparallaxes. We further derived constraints on the geometric albedo as a function of the planet’s brightness temperature.Results.We confirm the optical secondary eclipses for Kepler-10b (13σ), Kepler-78b (9.5σ), and K2-141b (6.9σ), with marginal evidence for K2-312b (2.2σ). We report new detections for K2-106b (3.3σ), K2-131b (3.2σ), Kepler-407b (3.0σ), and hints for K2-229b (2.5σ). For all targets, with the exception of K2-229b and K2-312b, we also find phase curve variations with a confidence level higher than 2σ.Conclusions.Two USP planets, namely Kepler-10b and Kepler-78b, show non-negligible nightside emission. This questions the scenario of magma-ocean worlds with inefficient heat redistribution to the nightside for both planets. Due to the youth of the Kepler-78 system and the small planetary orbital separation, the planet may still retain a collisional secondary atmosphere capable of conducting heat from the day to the nightside. Instead, the presence of an outgassing magma ocean on the dayside and the low high-energy irradiation of the old host star may have enabled Kepler-10b to build up and retain a recently formed collisional secondary atmosphere. The magma-world scenario may instead apply to K2-141b and K2-131b.
Trauma der Orbita
Authors: Zorn Malte , Liekfeld Anja , Bode-Hofmann Mechthild , Gabel-Pfisterer Ameli 
Published: November 2021

ZusammenfassungDie Behandlung orbitaler Verletzungen gehört zum Alltag der medizinischen Akutversorgung. Bei 10 – 25% aller Gesichtsverletzungen ist die Orbita beteiligt. Dieser Beitrag gibt einen Überblick über die möglichen Pathologien nach Orbitatrauma sowie das primärdiagnostische Vorgehen und die therapeutischen Optionen.
Switchable Synthesis of Sulfoxides, Sulfones and Thiosulfonates through Selectfluor-Promoted Oxidation with H2O as O-Source
Authors: Guo Xuqiang , Sun Xuejun , Zhao Yulei , Jiang Mengmeng 
Published: November 2021

AbstractA practical and efficient protocol for the switchable synthesis of sulfoxides, sulfones, and thiosulfonates via Selectfluor-mediated oxidation of sulfides and thiols, respectively, at ambient temperature has been developed. All these organosulfur compounds can be prepared with nearly quantitative yields by applying eco-friendly H2O as O-source. The formation of sulfoxides and thiosulfonates takes only a few minutes (3–20 min). As suggested by the control experiments, the oxidation procedure might proceed through the fluorination of sulfide, nucleophilic addition with H2O, and elimination of hydrogen fluoride.
Recent Advances in Palladium-Catalyzed Oxidative Couplings in the Synthesis/Functionalization of Cyclic Scaffolds Using Molecular Oxygen as the Sole Oxidant
Authors: Barboza Amanda Aline , Dantas Juliana Arantes , Jardim Guilherme Augusto de Melo , Ferreira Marco Antonio Barbosa , Costa Mateus Oliveira , Chiavegatti Attilio 
Published: November 2021

AbstractOver the past years, Pd(II)-catalyzed oxidative couplings have enabled the construction of molecular scaffolds with high structural diversity via C–C, C–N and C–O bond-forming reactions. In contrast to the use of stoichiometric amounts of more common oxidants, such as metal salts (Cu and Ag) and benzoquinone derivatives, the use of molecular oxygen for the direct or indirect regeneration of Pd(II) species presents itself as a more viable alternative in terms of economy and sustainability. In this review, we describe recent advances on the development of Pd-catalyzed oxidative cyclizations/functionalizations, where molecular oxygen plays a pivotal role as the sole stoichiometric oxidant.1	Introduction2	Oxidative C–C and C–Nu Coupling2.1	Intramolecular Oxidative C–Nu Heterocyclization Reactions2.1.1	C–H Activation2.1.2	Wacker/Aza-Wacker-Type Cyclization2.1.3	Tandem Wacker/Aza-Wacker and Cyclization/Cross-Coupling Reactions2.2	Intermolecular Oxidative C–Nu Heterocoupling Reactions2.3	Intramolecular Oxidative (C–C) Carbocyclization Reactions2.4	Intermolecular Oxidative C–C Coupling Reactions2.4.1	Cyclization Reactions2.4.2	Cross-Coupling Reactions2.4.3	Homo-Coupling Reactions3	Aerobic Dehydrogenative Coupling/Functionalization4	Oxidative C–H Functionalization5	Summary
Synthesis and Applications of Chiral Bicyclic Bisborane Catalysts
Authors: Wang Xiao-Chen , Yang Zhao-Ying , Zhang Ming 
Published: November 2021

AbstractThe development of chiral borane Lewis acid catalysts opened the door for transition-metal-free catalyzed asymmetric organic reactions. Herein, we have summarized our work on the preparation of two classes of novel chiral bicyclic bisborane Lewis acid catalysts derived from C
2-symmetric [3.3.0] dienes and [4.4] dienes, respectively. These catalysts not only form frustrated Lewis pairs with Lewis bases to catalyze asymmetric hydrogenation reactions but also activate Lewis basic functional groups in traditional Lewis acid catalyzed asymmetric reactions.1	Introduction2	Synthesis of C
2-Symmetric Fused Bicyclic Bisborane Catalysts and Their Use in Imine Hydrogenation3	Synthesis of Spiro Bicyclic Bisborane Catalysts and Their Use in ­N-Heteroarene Reduction4	Other Types of Asymmetric Reactions Promoted by Chiral ­Bicyclic Bisborane Catalysts5	Conclusion
The Clinical and Biological Effects of Homeopathically Prepared Signaling Molecules: A Scoping Review
Authors: Manchanda Raj Kumar , Gupta Meeta , Gupta Ankit , Haselen Robbert van 
Published: November 2021

Abstract
Background Signaling molecules such as cytokines and interleukins are key mediators for the immune response in responding to internal or external stimuli. Homeopathically prepared signaling molecules have been used therapeutically for about five decades. However, these types of products are not available in many countries and their usage by homoeopaths is also infrequent. The aim of this scoping review is to map the available pre-clinical and clinical data related to the therapeutic use of homeopathically prepared signaling molecules.
Methods We conducted a scoping review of clinical and pre-clinical studies of therapeutically used signaling molecules that have been prepared in accordance with an officially recognized homeopathic pharmacopoeia. Articles in peer-reviewed journals reporting original clinical or pre-clinical research of homeopathically prepared signaling molecules such as interleukins, cytokines, antibodies, growth factors, neuropeptides and hormones, were eligible. Non-English language papers were excluded, unless we were able to obtain an English translation. An appraisal of eligible studies took place by rating the direction of the outcomes on a five-point scale. The quality of the papers was not systematically assessed.
Results Twenty-eight eligible papers, reporting findings for four different manufacturers' products, were identified and reviewed. Seventeen papers reported pre-clinical studies, and 11 reported clinical studies (six experimental, five observational). A wide range of signaling molecules, as well as normal T-cell expressed specific nucleic acids, were used. A majority of the products (21 of 28) contained two or more signaling molecules. The most common clinical indications were psoriasis, vitiligo, rheumatoid arthritis, respiratory allergies, polycystic ovary syndrome, and herpes. The direction of the outcomes was positive in 26 papers and unclear in two papers.
Conclusion This scoping review found that there is a body of evidence on the use of homeopathically prepared signaling molecules. From a homeopathy perspective, these substances appear to have therapeutic potential. Further steps to explore this potential are warranted.
Peculiarities of shaping of architectural moulds and profiles in St. Petersburg architecture of the XVIII century
Authors: Vozniak E R 
Published: November 2021

Abstract
The article discusses the formation of moulds and string cornices in the St. Petersburg architecture of the XVIII century. Significant distinctions of Russian architectural moulds in comparison with their analogues existent in classical orders of Western European architecture are revealed. The causes lying underneath of the regional transformation of architectural elements are analyzed. The examples of designing profiles in each individual style period of the XVIII century are provided. It has been found out that the whole first half of the XVIII century is characterized by seamless profiles without complex intercalated moulds, such as dentils, modillions, and consoles. The inherent features of the Elizabethan Baroque are unique moulds with an upper notch. The period of Early Classicism is characterized with the usage of both Baroque and classical moulds in the style of J. Vignola. Strict classicism was the period when architects used moulds in the style of A. Palladio and the usual practice was application of Greek moulds. On the basis of the analysis carried out in the research, characteristic features and dating elements of each stylistic period are determined, and the elements inherent for the unique style of architects who created their works during the specified period are described.
Removal of Thorium from industrial waste via electrosorption technique
Authors: Aziman Eli Syafiqah , Ismail Aznan Fazli 
Published: November 2021

Abstract
Activated carbon electrode has been tested as a potential sorbent for removal of Th ions from the actual wastewater sampel by electrosorption technique. The objective of this research is to investigate the performance of activated carbon electrode for remediation of real thorium sample. Adsorption of thorium ion by activated carbon electrodes was investigated with contact time up to 180 minutes by using positive potential at 0.2V (vs. Ag/AgCl), 0.4V (vs. Ag/AgCl) and 0.6v (vs. Ag/AgCl). Result shows that the condition has the highest percentage of thorium ion removal is at 0.6V (vs. Ag/AgCl) with highest specific capacity at 0.5 mg Th/g Carbon. Based on this research, the removal of thorium through electrosorption technique has the tendency to remove thorium ion and parameter such as contact time of electrosorption and voltage applied should be studied in more depth, where the removal of thorium is expected to increase.
Perspectives of bark dump recycling at wood processing enterprises
Authors: Svoykin F , Birman A , Bacherikov I , Mater O , Bozhbov V 
Published: November 2021

Abstract
Woodworking and pulp-and-paper mill areas accumulate significant volumes of wood debarking waste, which is stored in bark dumps with a volume of up to 1 000 000 m3. Methods for recycling bark, both fresh and stagnant, are proposed through the production of fuel briquettes and pellets, composting, building materials, and the use of combustible gases that accumulate in the depths of the old bark layers. Characteristics of extractive substances obtained from bark are given and their fields of application are considered. Possible ways of recultivation of old bark dumps, ways of waste water treatment are offered. The recommendations on reduction of technogenic hazard of bark dumps are given and the necessity of constant monitoring of such objects is grounded. The technological scheme of complex use of bark dump materials on the basis of developments of Saint-Petersburg State Forest Technical University is proposed.