bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of characteristics and outcomes of a cohort of patients with severe and enduring eating disorders (SE-ED)
Authors: Piñar-Gutiérrez Ana , Dios-Fuentes Elena , Remón-Ruiz Pablo , Del Can-Sánchez Diego , Vázquez-Morejón Antonio , López-Narbona Marta , Dastis-Rodríguez de Guzmán Javier , Venegas-Moreno Eva , Soto-Moreno Alfonso 
Published: October 2021

Abstract
Objective
To describe the characteristics of the patients, as well as the treatment outcomes for the people treated in an Endocrinology and Nutrition unit with a diagnosis of SE-ED (> 7 years evolution despite evidence-based conventional treatment).

Methods
A descriptive observational study was conducted. Patients with a diagnosis of SE-ED (anorexia nervosa and bulimia nervosa) treated in the Endocrinology and Nutrition service of the Virgen del Rocío University Hospital between 2014 and 2019 were included.

Results
67 patients were contacted and accepted to participate in the study. 95.5% were women. 67.2% were diagnosed with AN (anorexia nervosa) and 32.8% with BN (bulimia nervosa). Their median ages (years) at the onset of symptoms, beginning of follow-up and at present were 17, 32 and 42.5 respectively. Their median time of follow-up was 9 years. 73.1% had mental comorbitidy and AN patients had more osteoporosis (48.9% vs 22.7%, p = 0.04) and hypogonadotropic hypogonadism (31.1% vs. 4.5%, p = 0.014).

Discussion
The SE-ED patients in our sample began treatment years after the onset of symptoms, which may have led to their chronification. This emphasizes the importance of an early diagnosis in eating disorders. They presented with a high rate of physical complications and mental comorbidity. In the current sample, it was determined that patients with AN presented with higher rates of osteoporosis and hypogonadotropic hypogonadism than patients with BN.

Level of evidence
Level III: Evidence obtained from well-designed cohort or case–control analytic studies.

Plain English summary
At present, the criteria for severe and enduring eating disorders (SE-ED) are not sufficiently clearly defined. It has been calculated that approximately 20% of patients with anorexia nervosa (AN) and 10% of patients with bulimia nervosa (BN) suffer a chronification. We evaluated the characteristics of the patients, as well as the treatment outcomes for the people treated in an Endocrinology and Nutrition unit with a diagnosis of SE-ED (which was made based on an evolution greater than 7 years despite conventional treatment). The SE-ED patients in our sample began treatment years after the onset of symptoms, which may have led to their chronification. They presented with a high rate of physical complications and mental comorbidity. In the current sample, it was determined that patients with AN presented with higher rates of osteoporosis (health condition that weakens bones, making them fragile and more likely to break) and hypogonadotropic hypogonadism (illness in which testes or ovaries produce little or no sex hormones due to a problem in the pituitary gland) than patients with BN.
Binge eating behavior in a sample of Lebanese Adolescents: Correlates and Binge Eating Scale validation
Authors: Mina Anthony , Hallit Souheil , Rogoza Radoslaw , Obeid Sahar , Soufia Michel 
Published: October 2021

Abstract
Background
Binge eating disorder is a common eating disorder among the adolescent population. The available literature in the Middle East in general, and Lebanon specifically, is relatively scarce and/or outdated. The objectives of this study were to (1) validate the Binge Eating Scale (BES) for use in Lebanese adolescents, and (2) assess correlates of binge eating behavior among this population.

Methods
A cross-sectional study conducted between May and June 2020, enrolling 555 adolescents between the ages of 15–18 years old from all Lebanese governorates. The Binge Eating Scale was used to screen for the presence/absence of binge eating.

Results
A confirmatory factor analysis revealed that the one-factorial model fits the data best. The results of a linear regression, taking the binge eating score as the dependent variable, showed that higher body dissatisfaction, more alcohol use disorder, higher depression, vomiting to lose weight and starving to lose weight were significantly associated with more binge eating. Higher self-esteem was significantly associated with less binge eating.

Conclusion
The Arabic Version of the BES scale seems to be a reliable tool to be used in Lebanese adolescents for the assessment of binge eating. More body dissatisfaction, lower self-esteem, increased depressive symptoms were associated with more binge eating. We hope this tool will be a reliable one to be used in epidemiological studies and research about eating behaviors/disorders.

Plain English summary
The results showed that higher body dissatisfaction, higher depression, vomiting to lose weight and starving to lose weight were significantly associated with more binge eating. Our study also showed that the Binge Eating Scale is an adapted and validated tool to be used among Lebanese adolescents for the assessment of binge eating. We hope that the study results will help clinicians in the screening and management of Binge Eating behaviors among Lebanese adolescents.
Size and shape of plates and size of wine glasses and bottles: impact on self-serving of food and alcohol
Authors: Clarke Natasha , Pechey Emily , Pechey Rachel , Ventsel Minna , Mantzari Eleni , De-loyde Katie , Pilling Mark A. , Morris Richard W. , Marteau Theresa M. , Hollands Gareth J. 
Published: October 2021

Abstract
Background
The physical properties of tableware could influence selection and consumption of food and alcohol. There is considerable uncertainty, however, around the potential effects of different sizes and shapes of tableware on how much food and alcohol people self-serve. These studies aimed to estimate the impact of: 1. Plate size and shape on amount of food self-served; 2.Wine glass and bottle size on amount of wine self-poured.

Methods
140 adults participated in two laboratory studies—each using randomised within-subjects factorial designs—where they self-served food (Study 1) and wine (Study 2):
Study 1: 3 plate sizes (small; medium; large) × 2 plate shapes (circular; square).
Study 2: 3 wine glass sizes (small; medium; large) × 2 wine bottle sizes (75 cl; 50 cl).

Results
Study 1: There was a main effect of plate size: less was self-served on small (76 g less, p < 0.001) and medium (41 g less, p < 0.001) plates, compared to large plates. There was no evidence for a main effect of plate shape (p = 0.46) or a size and shape interaction (p = 0.47).
Study 2: There was a main effect of glass size: less was self-served in small (34 ml less, p < 0.001) and medium (17 ml less, p < 0.001) glasses, compared to large glasses. There was no evidence of a main effect of bottle size (p = 0.20) or a glass and bottle size interaction (p = 0.18).

Conclusions
Smaller tableware (i.e. plates and wine glasses) decreases the amount of food and wine self-served in an initial serving. Future studies are required to generate estimates on selection and consumption in real world settings when numerous servings are possible.
Protocol registration information: OSF (https://osf.io/dj3c6/) and ISRCTN (10.1186/ISRCTN66774780).
Evaluation of utility and usefulness of webinars on COVID-19 management: a questionnaire-based survey
Authors: Gupta Rekha , Naik B. Naveen , Ganesh Venkata , Singh Ajay , Soni Shiv Lal , Puri G. D. 
Published: October 2021

Abstract
Background
The COVID-19 pandemic and its consequent “social distancing” has fueled the use of social media platforms for educational purposes. Since the start of the pandemic, a plethora of experts and self-proclaimed experts have been keenly delivering webinars on COVID. This begs the question “Do webinars on COVID-19 really help in the improvement of knowledge base or management skills?”. The questionnaire was designed to assess information regarding COVID-webinars and their usefulness from the end-user standpoint. The response to the questions was measured using a 4- or 5-point Likert scale. The survey was open for a 4-week period with the extension of 1 week.

Results
The response rate was 54% as 270 out of 500 participants responded to the questionnaire. The majority of the respondents were anesthesiologists in-training, post-graduates, fellows, and seniors belonging to tertiary care settings with fewer percentages belonging to physicians and others. Most of the doctors had attended an average of 2 webinars per week. The tests of model effects showed a significant negative correlation of webinar quality ratings for district hospital healthcare setting of the attendees (of p value of 0.013) and for the number of COVID-related webinars attended per week (p value of 0.009).

Conclusions
Most respondents had favorable perceptions of webinars happening during the pandemic. However, there is a need for improvisation in the volume of webinars, target-audience-based delivery, and participant interaction to add value to this new dimension of teaching-learning.
Pathways to care and supernatural beliefs among patients with psychotic disorders in Nepal
Authors: Gupta Anoop Krishna , Grover Sandeep , Thapaliya Suresh , Shrestha Shuva , Sawant Sandesh , Shoib Sheikh 
Published: October 2021

Abstract
Background
Longer pathways to care worsen the course of psychotic illness as well. The study aimed to assess the pathways to care, supernatural beliefs, and impact on the duration of untreated psychosis in patients with schizophrenia. It was a cross-sectional, observational study that involved 133 patients and their caregivers. Supernatural Attitude Questionnaire and World Health Organization Encounter form for Pathways to care were used to evaluate the pathways to care, supernatural beliefs in caregivers, and duration of untreated psychosis. SPSS descriptive and non-parametric tests were used for analysis.

Results
Overall, 59.4% of the participants had a non-medical person as the first treatment contact. Duration of untreated psychosis (DUP) for the whole study sample was 6.04 (SD 15.14) months and when it was compared among the first contact with a medical person (mean 4.43; SD 14.39) and non-medical person (mean 7.15; SD 15.63), the later had significantly longer (Mann-Whitney U = 1278; p < 0.001) DUP. More than half of the patients had one or more supernatural beliefs. Having supernatural beliefs and carryout rituals related to these beliefs is associated with a higher number of visits to different professionals before reaching a psychiatrist.

Conclusions
Patients with psychosis and their caregivers seek first help from non-medical persons, especially faith healers. This is associated with a longer duration of untreated psychosis and supernatural beliefs in caregivers. Thus, there is a need to improve mental health literacy and have public awareness programs to address the belief systems and clarify the prevailing myths in society.
A multicentric observational study of imaging findings in COVID-19-related rhino-orbito-cerebral mucormycosis: a new Pandora’s box
Authors: Singhal Annu , Jain Shikha , Sharma Swati , Kottiyath Vivek Cherumanalil , Khandelwal Girish 
Published: October 2021

Abstract
Background
There is a sudden rise of fungal infection with corona virus disease. This is attributed to the immunomodulation by the disease and the drugs used, diabetes mellitus, steroid use, oxygen inhalation using dirty water, use of zinc and iron supplements, etc. Early diagnosis and prompt medical and surgical intervention is the mainstay of treatment. This can greatly reduce the high morbidity and mortality associated with this disease. The objective of the study is to describe the imaging findings of acute invasive rhino-orbito-cerebral mucormycosis (ROCM) in 25 patients with severe acute respiratory syndrome corona virus 2, from three different centers with proven mucormycosis. Special emphasis is placed on the signal enhancement patterns of sinonasal mucosa, the earliest and most common findings. Statistical analysis was performed using descriptive statistics.

Results
Computed tomography (CT) and magnetic resonance imaging (MRI) of 25 patients showed most commonly involved sinuses as maxillary and ethmoid sinuses (19, 76%) together. Sino-nasal mucosal thickening was the most common finding (24, 96%). Periantral infiltration (18, 72%) preceded before orbital (15, 60%), cerebral (5, 20%) and vascular (2, 8%) complications, with grossly intact bones. Sinus wall erosions were seen in only 2 patients (8%). Palatal (22%) and maxillary alveolar arch erosion (39%) were frequent findings. CT showed minimally enhancing hypodense soft tissue thickening as the predominant finding in involved areas, while MRI showed T1 and T2 iso- to hypointense mucosal thickening (62%) and intense (43%) and no (33%) contrast enhancement as the main finding.

Conclusions
Contrast enhanced MRI is better at demonstrating early mucosal abnormalities, turbinate necrosis, non-enhancing devitalized tissues, orbital apex involvement and intra-cerebral extension. Imaging findings of inflammatory tissue infiltration adjacent to the paranasal sinuses in premaxillary, retroantral fat, facial muscles, pterygopalatine fossa, temporal, infratemporal fossa and extraconal orbital fat along with typical patterns of sinonasal mucosal enhancement should raise the suspicion of acute invasive fungal etiology given the short duration of history and immunocompromised status. High incidence of periantral and orbital extension of the disease is suggestive of acute invasive form of fungal infection. Also the rapidly progressive inflammatory changes without much bone involvement should suggest the suspicion of ROCM. Bony, cerebral and vascular involvements are relatively late complications.
Effect of retro walking versus balance training on pain and disability in patients with osteoarthritis of the knee: a randomized controlled trial
Authors: Krishnan Vijaya , Pithadia Krishna 
Published: October 2021

Abstract
Background
Osteoarthritis (OA) is a chronic, degenerative, inflammatory musculoskeletal dysfunction. It is associated with pain, reduced functional capacity, and deficient quality of life posing a challenge for rehabilitation. The study objective was to determine the treatment protocol for effectively managing pain and functional disability of patients with OA knee.

Methods
This is a single-blinded study conducted in the outpatient department of a tertiary care hospital. This three-arm study consisted of 20 patients randomly allocated to each group, prearranged to receive conventional treatment (group A), conventional treatment with retro walking training (group B), and conventional treatment with balance training (group C) for a time frame of 6 weeks. Patients were screened prior to the pre-set eligibility criteria before inclusion in the study. Pain and functional disability were assessed at the baseline and post-intervention.

Results
The findings reported 66.66% female participation. The results established statistical significance for both pain and functional disability across all the three groups for both intergroup and intragroup analysis. Group B demonstrated the most promising results.

Conclusion
The 6-week rehabilitation protocol comprising retro walking as an adjunct to conventional therapy resulted in greater pain reduction and enhanced functional performance of patients with OA knee. This benefits the community at large. All stakeholders should be encouraged to include retro walking in their routine life.

Trial registration
The University Hospital Medical Information Network Centre (UMIN-CTR), UMIN000044483. Retrospectively registered on June 09, 2021.
Nonfunctioning Pituitary Microadenomas: Should Imaging Interval be Extended? A Large Single-center Cohort Study
Authors: Han Ashley J , Varlamov Elena V , Fleseriu Maria 
Published: October 2021

Abstract

Context
Characterization of the clinical features and natural history of nonfunctioning pituitary microadenomas (NFPmAs) is limited by heterogeneous and small-scale studies.

Objective
To characterize the clinical presentation and natural history of NFPmAs and evaluate if imaging follow-up interval can be extended.

Methods
Retrospective single-center cohort study (years 2006-2021) of conservatively managed patients with NFPmAs. Initial symptoms, pituitary function, and tumor size were assessed. A change in NFPmA size ≥2 mm, as determined by pituitary or brain magnetic resonance imaging (MRI), was considered significant.

Results
There were 347 patients in the study cohort. Headache (78.4%) and fatigue (70.0%) were commonly reported despite no evidence of mass effect or significant pituitary hypofunction. Pituitary deficiencies at baseline were rare, with hypogonadism being most common (5.1%). During a median imaging follow-up period of 29 months (range 3-154), 8.1% of NFPmAs grew. Growth incidence was 2.1 per 100 person-years with a mean and median time to growth of 38.1 (SD ± 36.4) and 24.5 (interquartile range 12.0-70.8) months, respectively. Tumor growth was mild and not associated with new pituitary deficiencies or visual deficits.

Conclusion
These data indicate that the natural history of NFPmAs is overall benign. Consequently, we propose that the initial MRI follow-up timeline for NFPmAs can be extended up to 3 years unless a lesion is close to the optic chiasm, there are worrisome mass effect symptoms, or new pituitary deficiencies.
Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery: ERAS and Oesophagectomy
Authors: Moorthy Krishna , Halliday Laura 
Published: October 2021

AbstractEnhanced Recovery After Surgery (ERAS) protocols are widely used in oesophageal cancer surgery. Multiple studies have demonstrated that ERAS protocols are associated with a shorter length of stay and a reduction in the incidence of post-operative complications after oesophagectomy. However, there is substantial heterogeneity in the content of ERAS protocols and the delivery of these pathways can be challenging. This paper discusses the key recommendations for ERAS protocols in oesophageal cancer surgery and the barriers and facilitating factors for their successful implementation.
Prevalence and associates of depression among rural and urban Rwandan mothers and their daughters 26 years after the 1994 genocide against the Tutsi
Authors: Mutuyimana Celestin , Cassady Cindi , Sezibera Vincent , Nsabimana Epaphrodite 
Published: October 2021

Background: Mental disorders continue to be a challenge for Rwandan society, especially for women after the genocide against the Tutsi. The risk of inheritance of mental disorders is eminent. We therefore conducted a study on the prevalence of depression among grandmothers and their daughters using quantitative data. This paper explains in detail why and how the dataset was created, and it describes the dataset itself. This will allow readers to easily access and use the data. Methods: A sample of 309 dyads of mothers and daughters was recruited. Data were collected using the Mini International Neuropsychiatric Interview, Life Events Questionnaire and the Social Demographics Questionnaire. Data was analyzed using descriptive statistics, chi-square test, logistic regression, and one-way ANOVA.
Local invertibility and sensitivity of atomic structure-feature mappings
Authors: Pozdnyakov Sergey N. , Zhang Liwei , Ortner Christoph , Csányi Gábor , Ceriotti Michele 
Published: October 2021

Background: The increasingly common applications of machine-learning schemes to atomic-scale simulations have triggered efforts to better understand the mathematical properties of the mapping between the Cartesian coordinates of the atoms and the variety of representations that can be used to convert them into a finite set of symmetric descriptors or features. Methods: Here, we analyze the sensitivity of the mapping to atomic displacements, using a singular value decomposition of the Jacobian of the transformation to quantify the sensitivity for different configurations, choice of representations and implementation details. Results: We show that the combination of symmetry and smoothness leads to mappings that have singular points at which the Jacobian has one or more null singular values (besides those corresponding to infinitesimal translations and rotations). This is in fact desirable, because it enforces physical symmetry constraints on the values predicted by regression models constructed using such representations. However, besides these symmetry-induced singularities, there are also spurious singular points, that we find to be linked to the incompleteness of the mapping, i.e. the fact that, for certain classes of representations, structurally distinct configurations are not guaranteed to be mapped onto different feature vectors. Additional singularities can be introduced by a too aggressive truncation of the infinite basis set that is used to discretize the representations. Conclusions: These results exemplify the subtle issues that arise when constructing symmetric representations of atomic structures, and provide conceptual and numerical tools to identify and investigate them in both benchmark and realistic applications.
Development Management of Competence Centers
Authors: Viter K. 
Published: October 2021

The article provides a classification of centers of competence, which e subdivided into corporate, university, regional, industry, as well as excellent scientific and educational centers. The features of the work and areas of activity of each of the centers presented according to the classification are considered. In addition, the analysis of possible models of the competence center: value chain, digital integration platform and ecosystem carried out. The advantages and disadvantages of each of the models considered, their graphic interpretation presented.
Based on the results of consideration of each of the models of competence centers, a justification made for the choice of one or another model of the competence center, depending on the specifics of the organization. In the course of the research, the main digital competencies (soft skills and hard skills) also considered. In accordance with these competencies, an analysis was made of the compliance of these competencies with each of the three models of interaction between participants in the creation of products (services) (value chain, digital integration platform and ecosystem).
Because of the analysis, the choice of each of the considered models realized, depending on their compliance with new digital competencies.
Osteogenesis imperfecta: minimizing complications in oral surgery/orthodontic treatment
Authors: Jordan Kaye , Carter Emily , Devine Ciarán P , Tsichlaki Aliki , Jones Judith 
Published: October 2021

Osteogenesis imperfecta (OI) is a rare genetic condition that affects connective tissue and is primarily characterized by bone fragility. Owing to the progressive nature of the disease, patients require life-long management of the adverse effects and the subsequent complications they can experience. Since the introduction of bisphosphonates as a treatment modality, complications and bone deformities associated with OI have been minimized. However, intravenous bisphosphonates in young patients could present a new era of difficulties for the dental profession. We report on a case of a patient with OI who presented with severe orthodontic crowding and describe the multidisciplinary treatment planning required to minimize potential complications.CPD/Clinical Relevance: General dental practitioners should be aware of the characteristics of osteogenesis imperfecta and the potential complications associated with dental treatment.