bluuebunny/crossref_metadata_2025_split huggingface dataset:
European Green Deal as a matter of security
Authors: Polko P 
Published: December 2021

AbstractThe European Green Deal (EGD) is a set of policy initiatives by the European Union with the overarching and ambitious aim of making Europe climate neutral in 2050. Being world’s first ‘climate-neutral bloc’ and fulfilling other goals extending to many different sectors, including construction, biodiversity, energy, transport, food and others has also an impact on different sectors of security. The implementation of the tasks set out in the EGD requires taking into account the necessity of sustainability in reaching the goals, including not violating sectoral security in the EU Member States.Nexusapproach might be useful in the processes of finding and implementation of particular solutions.
Analysis of CAFM software for construction companies in the Czech
Authors: Rudl L 
Published: December 2021

Abstract
As part of property management, there is a constant increase in operating costs, whether they are new or old buildings. The amount of costs and their growth is related, among other things, to the use of space, the provision of services, the optimization of the working environment and the optimal functionality of the technological parts of the property. In the case of large properties or building complexes, it is therefore a separate branch of Facility Management. As part of the ongoing digitization in the field of construction, the development and implementation of facility management for the subsequent management of the building is also accelerating. There is currently several commercially available software that can be used as an effective tool for organizing, planning, and improving facility processes. The main goal of the work is to conduct a survey of existing and available software for facility management (CAFM) in the market environment of the Czech Republic and compare its functions, working environment in relation to the possibility of use in the construction company environment.
Radon monitoring in a historical building in Košice city, Slovakia – a case study
Authors: Singovszká E , Eštoková A , Vertaľ M 
Published: December 2021

Abstract
It is known that the highest contribution to the yearly radiation dose for the population derives from natural radioactivity. About 50% of that is estimated to be caused by exposure to radon (Rn) and its products. Human exposure to indoor Rn is currently considered a relevant research topic, because of the associated epidemiological aspects. This paper aimed at Rn concentration measurement in a selected building in Košice city, Slovakia. The continuous monitoring of indoor radon levels was performed over a period of 40 days. The measured concentrations ranged in a wide interval up to 92 Bq/m3. The WHO limit value of 100 Bq/m3 wasn´t exceeded. Analysing the possible sources, both contributions of radon from the building materials and radon from the soil was observed.
Soil contamination in the area of magnesite mining in urban and agrarian land
Authors: Stofejova L , Fazekasova D , Fazekas J 
Published: December 2021

Abstract
Contamination of soil with potential risk elements is one of the most pressing environmental problems in the world and causes serious environmental damage, but also threatens human health. This paper presents the results of research that was focused on analyzing soil contamination in the field of magnesite mining in urban and agrarian land nearby the former factory in Košice (Slovakia). Field and laboratory research were performed. Soil sampling was performed in 10 localities of the studied area. The content of risk elements (Cd, Hg, Pb, Cr, Zn, Cu, As, Ni, Mn, Mg) in soils was analyzed under laboratory conditions. The obtained data expressed as average concentrations of metals in sampled soils, as well as background values of the contents of monitored elements for the soils of the Slovak Republic, were used to assess soil pollution and identify the environmental risk. The acquired knowledge about the contamination of the soil with risk elements in the area around the former magnesite factory in Košice could help in the planning of remediation measures and improve the state of the environment in the studied area.
Bioaccumulation of toxic metals by fungi of the genus Aspergillus isolated from the contaminated area of Ostramo Lagoons
Authors: Vašinková M , Dlabaja M , Kučová K 
Published: December 2021

AbstractThe study compares the ability to bioaccumulate toxic metal ions using microscopic filamentous fungi of the genusAspergillusisolated from the anthropogenically contaminated site of the Ostramo Lagoons (Ostrava, Czech Republic). The experiment comprised six species of indigenous fungal isolates:A. niger, A. candidus, A. iizukae, A. westerdijkiae, A. ochraceus and A. clavatus.Nutrient liquid media enriched with Cu(II), Zn(II), Ni(II) and Cr(III) were individually inoculated with spores of these fungi. After thirty days of incubation, the content of metal ions in the dried fungal biomass and medium was measured by the AAS. It was found that the average bioaccumulation capacity of selected toxic metal within the tested strains decreases in the following order:A. ochraceus > A. candidus > A. clavatus > A. westerdijkiae > A. iizukae > A. niger.The highest bioaccumulation efficiency was achieved by theA. ochraceusstrain which accumulated Cu(II) with an efficiency of 57.42 %, Zn(II) with 56.88 %, Cr(III) with 37.73 %. When comparing the ability of bioaccumulation of the toxic metals, the following was found: Zn(II) > Cu(II) > Cr(III) > Ni(II). Understanding of bioaccumulation processes that take place in fungal cells at the molecular level may lead to better strategies for the application of these interesting microorganisms in bioremediation processes.
A note on stability of syzygy bundles on Enriques and bielliptic surfaces
Authors: Mukherjee Jayan , Raychaudhury Debaditya 
Published: December 2021

In this note, we prove that the syzygy bundle

M
L

M_L

is cohomologically stable with respect to

L
L

for any ample and globally generated line bundle

L
L

on an Enriques (resp. bielliptic) surface over an algebraically closed field of characteristic

≠
2

\neq 2

(resp.

≠
2
,
3

\neq 2,3

). In particular our result on complex Enriques surfaces improves the result of Torres-López and Zamora [Beitr. Algebra Geom. (2021)] (Corollary 3.5) by removing the condition on Clifford index. Together with the results of Camere [Math. Z 271 (2012), pp. 499–507] and Caucci–Lahoz [Bull. Lond. Math. Soc. 53 (2021), pp. 1030–1036], it implies that

M
L

M_L

is stable with respect to

L
L

for an ample and globally generated line bundle

L
L

on any smooth minimal complex projective surface

X
X

of Kodaira dimension zero.
EcoPLOT: dynamic analysis of biogeochemical data
Authors: Sanchez Christopher D , Brown J Benjamin , Gal-Oz Omree , Singer Esther 
Published: December 2021

Abstract

Motivation
We have created EcoPLOT (parameterized linkage of omics-driven technologies), a web-app for the dynamic, interactive analysis of biogeochemical datasets that combines state-of-the-art analysis tools to statistically and graphically explore environmental, geochemical and microbiome datasets. Using the iterative random forest, a machine learning algorithm, EcoPLOT allows for the de novo discovery of drivers which exhibit significant impact on plant, microbial or soil dynamics.

Availability and implementation
EcoPLOT is built entirely within the R language. It can be accessed through any system where R is installed, including Windows, Mac and most Linux systems. EcoPLOT is free to use and can be accessed at https://github.com/cdsanchez18/EcoPLOT.
CRPMKB: a knowledge base of cancer risk prediction models for systematic comparison and personalized applications
Authors: Ren Shumin , Jin Yanwen , Chen Yalan , Shen Bairong 
Published: December 2021

Abstract

Motivation
In the era of big data and precision medicine, accurate risk assessment is a prerequisite for the implementation of risk screening and preventive treatment. A large number of studies have focused on the risk of cancer, and related risk prediction models have been constructed, but there is a lack of effective resource integration for systematic comparison and personalized applications. Therefore, the establishment and analysis of the cancer risk prediction model knowledge base (CRPMKB) is of great significance.

Results
The current knowledge base contains 802 model data. The model comparison indicates that the accuracy of cancer risk prediction was greatly affected by regional differences, cancer types and model types. We divided the model variables into four categories: environment, behavioral lifestyle, biological genetics and clinical examination, and found that there are differences in the distribution of various variables among different cancer types. Taking 50 genes involved in the lung cancer risk prediction models as an example to perform pathway enrichment analyses and the results showed that these genes were significantly enriched in p53 Signaling and Aryl Hydrocarbon Receptor Signaling pathways which are associated with cancer and specific diseases. In addition, we verified the biological significance of overlapping lung cancer genes via STRING database. CRPMKB was established to provide researchers an online tool for the future personalized model application and developing. This study of CRPMKB suggests that developing more targeted models based on specific demographic characteristics and cancer types will further improve the accuracy of cancer risk model predictions.

Availability and implementation
CRPMKB is freely available at http://www.sysbio.org.cn/CRPMKB/. The data underlying this article are available in the article and in its online supplementary material.

Supplementary information
Supplementary data are available at Bioinformatics online.
Intersectionality and Transnationalism in Lailā Al-Johanī’s Jāhiliyya (Age of Ignorance)
Authors: Al-Sharqi Laila M 
Published: December 2021

Abstract
Lailā Al-Johanī’s 2007 novel, Jāhiliyya (Days of Ignorance), is an innovative fictional work that employs the concept of “Jāhiliyya,” a period of ignorance that is thought to have characterized pre-Islamic Arabia. Jāhiliyya expresses Al-Johanī’s critique of the prevailing social and religious practices adapted by some tribal members of her society. These practices, including racial discrimination, negative stereotyping, and marginalization of women, as depicted in Al-Johanī’s text, are detrimental in their effect on the cultural fabric of society. This study uses intersectionality as an analytical framework through which to examine Al-Johanī’s Jāhiliyya. The essay demonstrates the novel’s integration of aspects of gender, race, and religion as interlocking systems of oppression and sites of transgression in the characters’ lives as they attempt to comprehend their subjectivity, while articulating and negotiating their society’s essentialist and reductionist discourse.
Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis
Authors: Lei Lucy Y , Raj Satish R , Sheldon Robert S 
Published: December 2021

AbstractAimsVasovagal syncope (VVS) is a common clinical condition that lacks effective medical therapies despite being associated with significant morbidity. Current guidelines suggest that midodrine, a prodrug for an α1-adrenergic receptor agonist, might suppress VVS but supporting studies have utilized heterogeneous methods and yielded inconsistent results. To evaluate the efficacy of midodrine to prevent syncope in patients with recurrent VVS by conducting a systematic review and meta-analysis of published studies.Methods and resultsRelevant randomized controlled trials were identified from the MEDLINE, Embase, CENTRAL, and CINAHL databases without language restriction from inception to June 2021. All studies were conducted in clinical syncope populations and compared the benefit of midodrine vs. placebo or non-pharmacological standard care. Weighted relative risks (RRs) were estimated using random effects meta-analysis techniques. Seven studies (n = 315) met inclusion criteria. Patients were 33 ± 17 years of age and 31% male. Midodrine was found to substantially reduce the likelihood of positive head-up-tilt (HUT) test outcomes [RR = 0.37 (0.23–0.59), P &lt; 0.001]. In contrast, the pooled results of single- and double-blind clinical trials (I2 = 54%) suggested a more modest benefit from midodrine for the prevention of clinical syncope [RR = 0.51 (0.33–0.79), P = 0.003]. The two rigorous double-blind, randomized, placebo-controlled clinical trials included 179 VVS patients with minimal between-study heterogeneity (I2 = 0%) and reported a risk reduction with midodrine [RR = 0.71 (0.53–0.95), P = 0.02].ConclusionsMidodrine is effective in preventing syncope induced by HUT testing and less, but still significant, RR reduction in randomized, double-blinded clinical trials.
Association of Long-Term Body Weight Variability With Dementia: A Prospective Study
Authors: Chen Hui , Zhou Tianjing , Guo Jie , Ji John S , Huang Liyan , Xu Weili , Zuo Guangmin , Lv Xiaozhen , Zheng Yan , Hofman Albert , Ma Yuan , Yuan Changzheng 
Published: December 2021

Abstract

Background
Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.

Methods
In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).

Results
Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48–2.72; HR of each SD increment: 1.21, 95% CI: 1.10–1.32; p-trend &lt; .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03–1.23) and was more pronounced for that closer to diagnosis.

Conclusion
Our prospective study suggested that greater BWV may be a novel risk factor for dementia.
The crustal structure of the Anatolian Plate from receiver functions and implications for the uplift of the central and eastern Anatolian plateaus
Authors: Ogden C S , Bastow I D 
Published: December 2021

SUMMARYUnderstanding the crustal structure of the Anatolian Plate has important implications for its formation and evolution, including the extent to which its high elevation is maintained isostatically. However, the numerous teleseismic receiver function studies from which Anatolian Moho depths have been obtained return results that differ by ≤21 km at some seismograph stations. To address this issue, we determine Moho depth and bulk crustal VP/VS ratio (κ) at 582 broad-band seismograph stations, including ∼100 for which H–κ results have not been reported previously. We use a modified H–κ stacking method in which a final solution is selected from a suite of up to 1000 repeat H–κ measurements, each calculated using randomly selected receiver functions and H–κ input parameters. Ten quality control criteria that variously assess the final numerical result, the receiver function data set, and the extent to which the results are clustered tightly, are used to determine station quality. By refining Moho depth constraints, including identifying 182 stations, analysed previously, where H–κ stacking yields unreliable results (particularly in Eastern Anatolia and the rapidly uplifting Taurides), our new crustal model (ANATOLIA-HK21) provides fresh insight into Anatolian crustal structure and topography. Changes in Moho depth within the Anatolian Plate occur on a shorter length-scale than has sometimes previously been assumed. For example, crustal thickness decreases abruptly from &gt;40 km in the northern Kirsehir block to &lt;32 km beneath the Central Anatolian Volcanic Province and Tuz Golu basin. Moho depth increases from 30–35 km on the Arabian Plate to 35–40 km across the East Anatolian Fault into Anatolia, in support of structural geological observations that Arabia–Anatolia crustal shortening was accommodated primarily on the Anatolian, not Arabian, Plate. However, there are no consistent changes in Moho depth across the North Anatolian Fault, whose development along the Intra-Pontide and İzmir-Ankara-Erzincan suture zones was more likely the result of contrasts in mantle lithospheric, not crustal, structure. While the crust thins from ∼45 km below the uplifted Eastern Anatolian Plateau to ∼25 km below lower-lying western Anatolia, Moho depth is generally correlated poorly with elevation. Residual topography calculations confirm the requirement for a mantle contribution to Anatolian Plateau uplift, with localized asthenospheric upwellings in response to slab break-off and/or lithospheric dripping/delamination example candidate driving mechanisms.
A Derived Gabriel–Popescu Theorem for t-Structures via Derived Injectives
Authors: Genovese Francesco , Ramos González Julia 
Published: December 2021

AbstractWe prove a derived version of the Gabriel–Popescu theorem in the framework of dg-categories and t-structures. This exhibits any pretriangulated dg-category with a suitable t-structure (such that its heart is a Grothendieck abelian category) as a t-exact localization of a derived dg-category of dg-modules. We give an original proof based on a generalization of Mitchell’s argument in A quick proof of the Gabriel-Popesco theorem that involves derived injective objects. As an application, we provide a short proof of the fact that derived categories of Grothendieck abelian categories have a unique dg-enhancement.
Role of AxyABM overexpression in acquired resistance in Achromobacter xylosoxidans
Authors: Magallon Arnaud , Amoureux Lucie , Garrigos Thomas , Sonois Marine , Varin Véronique , Neuwirth Catherine , Bador Julien 
Published: December 2021

Abstract

Background
Acquired antimicrobial resistance among Achromobacter isolates from cystic fibrosis (CF) patients is frequent. Data concerning the mechanisms involved are scarce. The role of the AxyXY-OprZ and AxyEF-OprN Resistance Nodulation Division (RND) efflux systems has been demonstrated, but not that of AxyABM.

Objectives
To explore the role of efflux systems in the acquired multiresistance observed in a one-step mutant selected after ofloxacin exposure.

Methods
The in vitro resistant mutant NCF-39-Bo2 and its parental strain NCF-39 (MICs of meropenem of 8 and 0.19 mg/L, of ceftazidime of 12 and 3 mg/L, of cefiderocol of 0.094 and 0.032 mg/L and of ciprofloxacin of 8 and 1.5 mg/L, respectively) were investigated by RNA-seq and WGS. Gene inactivation and reverse transcription quantitative PCR (RT–qPCR) were used to explore the role of the efflux systems of interest.

Results
RNA-seq showed that the AxyABM efflux system was overproduced (about 40-fold) in the in vitro mutant NCF-39-Bo2 versus its parental strain NCF-39. A substitution in AxyR, the putative regulator of AxyABM, was detected in NCF-39-Bo2. Gene inactivation of axyB (encoding the transporter component) in NCF-39-Bo2 led to a decrease in MICs of ciprofloxacin (5-fold), meropenem (64-fold), ceftazidime (12-fold) and cefiderocol (24-fold). Inactivation of axyB in the clinical isolate AXX-H2 harbouring a phenotype of resistance close to that of NCF-39-Bo2 enhanced the activity of the same molecules, especially meropenem.

Conclusions
AxyABM overproduction is involved in acquired resistance of Achromobacter to ciprofloxacin, meropenem and ceftazidime, antibiotics widely used in CF patients, and increases the MIC of the new promising antibiotic cefiderocol.
Integrated Tick Management in Guilford, CT: Fipronil-Based Rodent-Targeted Bait Box Deployment Configuration and Peromyscus leucopus (Rodentia: Cricetidae) Abundance Drive Reduction in Tick Burdens
Authors: Linske Megan A , Williams Scott C , Stafford Kirby C , Li Andrew Y 
Published: December 2021

Abstract
Integrated tick management (ITM) is a comprehensive strategy used to reduce presence of ticks and their associated pathogens. Such strategies typically employ a combination of host and non-host targeted treatments which often include fipronil-based, rodent-targeted bait boxes. Bait boxes target small-bodied rodents, specifically white-footed mice (Peromyscus leucopus Rafinesque) that not only play a crucial role in the blacklegged tick (Ixodes scapularis Say (Ixodida: Ixodidae)) life cycle, but also in the transmission of numerous pathogens, primarily Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt & Brenner (Spirochaetales: Spirochaetaceae), the causal agent of Lyme disease. This study aimed to determine the effect of bait box deployment configuration on tick burden reduction while also further exploring bait consumption and P. leucopus abundances as measures of bait box usage and effectiveness. Boxes were deployed on nine properties within each of six neighborhoods (n = 54) in two different configurations: grid and perimeter. Multiple factors were analyzed as potential predictors for reduction in tick burdens using a backward stepwise selection procedure. Results confirmed the perimeter configuration was a more effective deployment strategy. In addition, overall P. leucopus abundance was a significant predictor of tick burden reduction while bait consumption was not. These findings not only further support the recommended perimeter deployment configuration but provide insight into effective utilization in areas of high P. leucopus abundance. The identification of this significant relationship, in addition to configuration, can be utilized by vector control professionals and homeowners to make informed decisions on bait box placement to make sustained impacts on the I. scapularis vector and associated pathogens within an ITM framework.