bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging Global Partnerships to Achieve SDG 7: A Case Study of Pakistan
Authors: Raza Khalil , MOHAZZAM Sardar , QAYYUM Saadia , SOOMRO Manzoor Hussain 
Published: April 2021

Abstract
Energy is fundamental to socio-economic growth for the world; but how this energy is generated and distributed would determine whether the world could achieve a sustainable future. There is no denying the fact that energy is one of the primary sources of greenhouse gas (GHG) emissions. Thus, addressing the climate crisis, sustainable energy lies at the core of both the United Nations’ Sustainable Development Goals (SDG) and the Paris Agreement. Among other goals, SDG 7 calls for affordable, reliable, sustainable and modern energy for all by 2030 (UNDP, 2017). Globally, about 1.2 billion people lack access to electricity. The situation is more dire for clean cooking with about 2.8 billion people – 30% of the world’s population – lacking access (Sustainable Energy for All, 2020). The fact is that the energy use in developing countries would continue to increase (Catherine, Orie, & Paul, 2012). This growth could provide an opportunity for the deployment of renewable energy sources, as well as the creation of new, more efficient energy infrastructure. Unfortunately, for developing countries, the clean energy solutions are neither affordable nor accessible, even with the decline in the cost of renewable energy technologies. As a result, many global initiatives and partnerships, such as Sustainable Energy for All (SEforALL), Global Environment Facility (GEF) and Green Climate Fund (GCF) have been established and working towards achieving this goal (Global Environment Facility (GEF), 2017). However, there is still a need to emphasize and reinforce this partnership to achieve the universal energy access by 2030. The world community has developed many platforms and financing mechanisms to transfer the resources from industrialized nations to developing countries, such as Clean Development Mechanism (CDM) under Kyoto protocol (UNFCCC, 2012). However, these mechanisms have not been really effective in encouraging investments in clean energy due to low carbon pricing. Hence, this necessitates for international community to come forward for the development of innovative assistance programs for developing nations by investing more resources to achieve SDG 7. Therefore, to accelerate the clean energy transition, global parternerhips and technological platforms will be needed to make clean energy investment economically competitive and viable. This work presents a case study on Pakistan’s response to achieve the SDG 7 under the UN global mission of Sustainable Energy for All (SEforALL) program. It discusses the key milestones, barriers and lessons learnt on SDG 7. Based on the experiences of Pakistan, this work explores viable alternatives of financing mechanisms to accelerate sustainable energy. The paper concludes with key recommendations as to how global partnership could unleash the technological and financial opportunities in achieving ambitious and universal goals of sustainable energy.
Defining and Characterising a Toolkit for the Development of a Successful European Registry for Rare Liver Diseases.
Authors: Pericleous Marinos , Bythel Mary , Schilsky Michael , Dhawan Anil , Kelly Claire , Ala Aftab 
Published: April 2021

Abstract
Background:

A rare disease is defined by the European Health Commission as a disorder affecting less than 5/10,000 population. There are at least 20 rare liver diseases seen frequently in the adult and paediatric liver clinic, signifying that the hepatology community can be influential in developing such patient databases for registering patients with rare hepatic conditions. The aim of this systematic review was to 1) identify registries for rare liver diseases in Europe and 2) design a universal blueprint for the development of a registry for rare liver diseases by using lessons learnt from the already established European registries.
Methods:

We searched PubMed, google scholar and clinicaltrials.gov using the MESH terms “registries”, “database management systems”, “database” and the non-MESH terms “database$”, “registry”, “repository” and “repositories”. We only included studies in English from countries/consortia of the European Union (EU). Our literature search was performed in 2020.
Results:

We identified 37 registries for rare liver disease in Europe. Using information from the design of these registries we developed a blueprint for the development of a patient registry for rare liver diseases consisting of a theoretical, technical and maintenance phase.
Interpretation:

It is believed that rare diseases may affect as much as 6–8% of the EU population across its 28 member states. Here we have provided a toolkit for designing a registry for rare liver disease. Our article will complement the efforts of loco-regional, national and international groups seeking to establish robust systems for data collection and analysis for orphan liver diseases.
Interfacial Manipulation via In-Situ Grown ZnSe Overlayer toward Highly Reversible Zn Metal Anodes
Authors: Yang Xianzhong , Li Chao , Sun Zhongti , Yang Shuai , Shi Zixiong , Huang Rong , Liu Bingzhi , Li Shuo , Wu Yuhan , Wang Menglei , Su Yiwen , Dou Shi Xue , Sun Jingyu 
Published: April 2021

Abstract
Zn metal anode has garnered growing scientific and industrial interest owing to its appropriate redox potential, low cost and good safety. Nevertheless, the instability of Zn metal, caused by dendrite formation, hydrogen evolution and side reactions, gives rise to poor electrochemical stability and unsatisfactory cycling life, greatly hampering large-scale utilization. Herein, an in-situ grown ZnSe layer with controllable thickness is crafted over one side of commercial Zn foil via chemical vapor deposition, aiming to achieve optimized interfacial manipulation between aqueous electrolyte/Zn anode. Thus-derived ZnSe overlayer not only prevents water penetration and restricts Zn2+ two-dimensional diffusion, but also homogenizes the electric field at the interface and facilitates favorable (002) plane growth of Zn. As a result, dendrite-free and homogeneous Zn deposition is obtained; side reactions are concurrently inhibited. In consequence, a high Coulombic efficiency of 99.2% and high cyclic stability for 860 cycles at 1.0 mA cm–2 in symmetrical cells is harvested. Meanwhile, when paired with V2O5 cathode, assembled full cell achieves an outstanding initial capacity (200 mAh g–1) and elongated lifespan (a capacity retention of 84% after 1000 cycles) at 5.0 A g–1. Our highly reversible Zn anode enabled by the interfacial manipulation strategy is anticipated to satisfy the demand of industrial and commercial use.
Implementation of a Clinical Decision Support System for Precision Oncology across an Academic Network
Authors: Tamborero David , Dienstmann Rodgrigo , Rachid Maan , Boekel Jorrit , Lopez-Fernandez Adria , Braña Irene , De Petris Luigi , Yachnin Jeffrey , Baird Richard , Massard Christophe , Opdam Frans , Schlenk Richard , Vernieri Claudio , Masucci Michele , Villalobos Xenia , Chavarria Elena , Balmaña Judith , Apolone Giovanni , Caldas Carlos , Bergh Jonas , Ernberg Ingemar , Fröhling Stefan , Garralda Elena , Karlsson Claes , Tabernero Josep , Voest Emile , Rodon Jordi , Lehtiö Janne 
Published: April 2021

Abstract
There is a growing need for systems that efficiently support the work of medical teams at the precision oncology point-of-care. Here we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical decision support system that creates a unified legal, scientific and technological platform to share and harness next-generation sequencing data across the Cancer Core Europe network. Automating the interpretation and reporting of sequencing results decreased drastically the need for manual procedures that are time consuming and prone to errors. In addition, the adoption of an expert-agreed process to systematically link tumor molecular profiles with clinical actions promoted consistent decision-making and structured data capture across centers. Finally, the use of information-rich patient reports with interactive content facilitated collaborative discussion of complex cases during virtual molecular tumor board meetings. Overall, we believe that streamlined digital systems like the MTBP are crucial to better address the challenges brought by precision oncology and accelerate the use of emerging biomarkers.
Grasping via entanglement
Authors: Wood Robert , Becker Kaitlyn , Teeple Clark , Charles Nicholas , Mahadevan L. 
Published: April 2021

Abstract
We present a grasping strategy for complex shapes via the collective entanglement of and by an array of actuated filaments. The basic unit of this array is a slender hollow elastomeric filament that is pneumatically actuated to form a highly curved structure. The multiple self and mutual contact interactions between the filaments and the object create a randomly tangled spatial assemblage that enables a soft conformable grasp. We realize this using a gripper enabled by a new fabrication method to create inexpensive and modular arrays of fluidically actuated elastomeric filaments. We demonstrate that a collective of highly compliant filamentous actuators is capable of a soft, adaptable grasp across a range of loads that vary in size, shape, and geometric and topological complexity without any feedback. A theoretical framework for the collective mechanics of filaments in contact with complex objects allows us to explain our experimental findings, while a phase diagram characterizes the design space in terms of the properties of the gripper and the target. Overall, our grasping approach adapts to the mechanical, geometric, and topological complexity of target objects via an uncontrolled, spatially distributed, and heterogeneous scheme without perception or planning, in sharp contrast with current deterministic feedback-driven robotic grasping methods.
Kosovo women’s knowledge and awareness of human papillomavirus (HPV) infection, HPV vaccination, and its relation to cervical cancer
Authors: Raçi Pranvera Zejnullahu , Raçi Fitim , Hadri Teuta 
Published: April 2021

Abstract
Background

The objective of this study, the first of its kind in Kosovo, is to determine the level of Kosovo women’s knowledge and awareness of HPV infection, HPV vaccination, and its relation to cervical cancer.
Methods

This cross-sectional study was conducted from July to October 2018 at the Clinic of Obstetrics and Gynecology at the Hospital and University Clinical Service of Kosovo.
Results

Out of 800 questionnaires distributed, 645 were completed and returned (80.6%). Only 0.5% of women were vaccinated against HPV. The majority of respondents (66.4%) had no previous knowledge of HPV (human papillomavirus). Only 27.6% of respondents were aware that HPV is responsible for cervical cancer. About two-thirds (70.1%) of respondents had never heard of the HPV vaccine, and only 24% knew that the HPV vaccine can prevent cervical cancer.
Conclusion

The level of vaccination against HPV and the level of knowledge and awareness of HPV infection is extremely low. Higher education, younger age, and living in an urban area were favorable factors and correlated with awareness of HPV infection, vaccination against it, and its relation to cervical cancer. Based on this study, there is an immediate need for developing an educational program on HPV infection and the importance of HPV vaccination as a preventative measure against developing cervical cancer.
Bioremidation of Spirulina Plantesis Against Deltamethrin Mediated Toxicity and Its Chemical Residues in Chicken Meat
Authors: Ibrahim Samar Saber , Elsabagh Rasha , Allam Ali , Youssef Gehan , Fadl Sabreen Ezzat , Abdelhiee Ehab Yahya , Alkafafy Mohamed , Soliman Ahmed , Aboubakr Mohamed 
Published: April 2021

Abstract
Deltamethrin (DM) is a synthetic pyrethroid insecticide commonly used in veterinary and agriculture. However, both animal and human exposure is associated with hepatorenal toxicity. Our experimental goal was to assess the protective effects of Spirulina plantesis (SP) against DM-induced hepato-renal injury, growth performance, meat chemical composition and its residues in meat, liver and skin of broiler chickens. Sixty one-day-old Cobb broiler chicks were assigned to 4 experimental groups, each was divided into 3 replicates with five chicks each; 1st group received basal diet alone (Control), 2nd group supplemented with SP 20 g/kg diet, 3rd group supplemented with DM 300 mg/kg diet, and 4th group supplemented with DM and SP diet. All groups were received the treatment for 35 days. DM, decreased body weight, weight gain, and increased feed conversion rate. DM showed significant increase in ALT, AST, urea, creatinine and MDA and significant decrease in SOD, and GSH levels. Also, significant decrease in DM levels in meat, skin, and liver by SP with a reduction % 63.01, 63.00 and 62.90 % in meat, skin and liver, respectively. The DM intoxicated group showed significant decrease in protein and significant increase in fat, cholesterol and triglycerides when compared to control group. Histopathological changes were also recorded. Dietary SP improved these parameters parameters. Dietary inclusion of SP can be recommended due to the protective effects on DM induced toxicity in broiler chickens.
Changes in Soil Microbial Community Structure and Functional Genes Following with Different Functional Traits Species Afforestation
Authors: Gao Yang , Wang Xiuwei , Mao Zijun , Yang Liu , Jiang Zhiyan , Chen Xiangwei , Aubrey Doug P. 
Published: April 2021

Abstract
Aim Soil microbial community structure and functional genes are critical to the cycling of carbon and nutrients in forest soils. As afforestation practices increasingly promote different functional traits tree species, it becomes critical to understand how they influences soil microbial community structures and functional genes, which directly influence soil biogeochemical processes. Methods We used fungi ITS and bacteria 16S rDNA to investigate soil microbial communities and functional genes in three monoculture plantations consisting of a non-native evergreen conifer (Pinus sibirica), a native deciduous conifer (Larix gmelinii), and a native deciduous angiosperm (Betula platyphylla) to compare with two 1:1 mixed-species plantations (P. sibirica and L. gmelinii, P. sibirica and B. platyphylla).Results The fungal community structure of the conifer-angiosperm mixed plantation was similar to that of the non-native evergreen conifer, and the bacterial community structure was similar to that of the angiosperm monoculture plantation. Fungal communities were strongly related to tree species, but bacteria communities were strongly related to soil nitrogen. Microbial co-occurrence patterns varied according to plantation types and altered soil nutrient cycling. Microbial communities in forest plantations of conifer-angiosperm mixed plantation contribute to soil nitrogen fixation and coniferous mixed plantation contribute to soil carbon fixation. Conclusions Our results provide a comparative study of the soil microbial ecology in afforestation of different functional trains species. This knowledge enhances the understanding of the relative control of soil microbial community structure.
Analysing Vehicular Mobility Structure Under a Temporal Perspective
Authors: Diniz Gabriel DA Ribeiro , Cunha Felipe Domingos da , Loureiro Antonio A. F. 
Published: April 2021

Abstract
In recent years, Vehicular Networks have received much attention because they can contribute to solving several problems of urban scenarios. An interesting perspective to characterize these urban problems is to study vehicles' mobility records to increase our knowledge about them. Thus, an alternative is to model these records as graphs enabling us to apply algorithms and graph theory to design new solutions for vehicular networks. This work explores three different strategies to model vehicular networks and analyzes two real well-known traces from Rome and San Francisco. We perform a study on the network aspect, measuring metrics that portray some network characteristics and proprieties. We highlight the advantages and limitations of each approach evaluated. Also, we present some applications and future directions for the knowledge extracted with this analysis.
The antimicrobial potentialities of (Nk-lysin peptides of chicken, bovine, and human) against bacteria and rotavirus
Authors: Mahmoud Maged. M , Al-Hejin Ahmed M. , Abujaml Turki S , Abd-Elmaksoud S , El-Hamidy Salem M. , Yacoub Haitham 
Published: April 2021

Abstract
For the first time, this study was carried out to investigate and evaluate the relative antibacterial activity of three different Nk-lysin peptides from human, chicken, and bovine activity compared to Gram-negative and Gram-positive bacteria as well as antiviral activity against rotavirus (strain SA-11) and finally mechanisms of action optionality. This report is the first of its kind that investigates the increased antimicrobial ability of (Nk-lysin + AgNPs) and (Nk-lysin + human IL-2) combinations against S. typhi activity by carrying out direct comparison under similar experimental settings. Our results showed that gram-negative and gram-positive microorganisms, including Streptococcus pyogenes, Streptococcus mutans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella oxytoca, Shigella sonnei, Klebsiella pneumoniae and Salmonella typhimurium, are susceptible to NK-lysin treatment. It was shown in our findings that there was equal potentiality in mixture (Nk-lysin + AgNPs) and (Nk-lysin + human IL-2) for preventing the growth of S. typhi, however, when added together, there was minor increase in the level of action. In our study, the TOHO-1 gene was absent in treated bacteria. Following treatment with Nk-lysin peptides, the beta-lactamases genes (CTX-M-1, M-8, and M-9) were not found in any bacterial strains. The examination did not find any of the plasmid mediated quinolone resistance genes in the bacterial strains as a response to NK-lysin treatment. Nonetheless, no study has been carried out in the past that characterized the antiviral activity of bovine, human and chicken Nk-lysin peptides. Hence, this is the foremost study on the enhanced antimicrobial activity of human, bovine and chicken Nk-lysin peptides against Rotavirus (strain SA-11). The findings of the study demonstrated that the powerful antiviral activities were exhibited by Nk-lysin peptides against Rotavirus (strain SA-11). Based on the comparison between these peptides, it can be concluded that there is an evident potent antiviral activity of bovine Nk-lysin against Rotavirus (strain SA-11) as it restrains infection by up to 90%. However, growth was restricted by 80% by chicken Nk-lysin and by 50% by the human peptide.
When Efficacy and Adherence Conflict: Preferences and Patterns of Response to Public Health Advice During the COVID-19 Pandemic
Authors: Nov Oded , Dove Graham , Balestra Martina , Lawrence Katharine , Mann Devin , Wiesenfeld Batia 
Published: April 2021

Abstract
With recurring waves of the Covid-19 pandemic, a dilemma facing public health leadership is whether to provide public advice that is medically optimal (e.g., most protective against infection if followed), but unlikely to be adhered to, or advice that is less protective but is more likely to be followed. To provide insight about this dilemma, we examined and quantified public perceptions about the tradeoff between (a) the stand-alone value of health behavior advice, and (b) the advice’s adherence likelihood. In a series of studies about preference for public health leadership advice, we asked 1,061 participants to choose between (1) strict advice that is medically optimal if adhered to but which is less likely to be broadly followed, and (2) relaxed advice, which is less medically effective but more likely to gain adherence-given varying infection expectancies. Participants’ preference was consistent with risk aversion. Offering an informed choice alternative that shifts volition to advice recipients only strengthened risk aversion, but also demonstrated that informed choice was preferred as much or more than the risk-averse strict advice.
Exploring the Involvement of FoxM1 in CML Cells from DNA Damage Response-Regulatory Prospective
Authors: Du Lin , Wang Manli , Li Hui , Wang Fang 
Published: April 2021

Abstract
Background

FoxM1 is widely accepted as an oncogenesis factor, for it is one of the most frequently upregulated genes in a broad spectrum of human malignancies. Herein, we presented the status of FoxM1 in CML samples and cell lines.
Methods

We compared FoxM1 abundance and phosphorylation using PB-MNC samples from CML patients and healthy donors. DNA damage response (DDR) was investigated in the presence of oncogene or chemical. Through enforced expression of FoxM1 or lentivirus mediated silencing, we explored the participation of FoxM1 in DDR regulation.
Results

Overexpression of FoxM1 was only observed in 3 samples from patients of advanced stage. However, hyper-phosphorylation of FoxM1 was evidently detected in the CML cohort. Furtherly, the DNA damage response that in accompany with the formation of Bcr/Abl was responsible for the rise in FoxM1 phosphorylation. Bcr/Abl provoked a modest extent of DNA damage, which, in turn, roused the repair system, mirrored by phosphorylation of the ATM/ATR-CHK1/2 axis. FoxM1 was a downstream target of CHK1 which directly associated with FoxM1 in the presence of DNA damage. Activation of FoxM1 served as a DDR regulator by inducing the expression of Rad51 and Brca1, genes that participated in DNA repair. Depletion of FoxM1 impaired DNA repair, leading to cell cycle arrest in G2/M phase and the onset of apoptosis in a P53-dependent fashion. Finally, our data demonstrated that phosphorylation of FoxM1 did not rely on Bcr/Abl kinase activity. Suppression of FoxM1 showed lethal potential to primary CML cells, and most importantly, the lethality was not affected by the TKIs insensitiveness.
Conclusions

Abnormality in FoxM1 activity in CML cells enlightened us that constantly present DNA damage rendered leukemia cells more reliant upon the DNA damage repair system. Targeting FoxM1 could be exploit as an alternative strategy to overcome TKIs resistance.