bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Potent Novel Biomarkers of Uterine Leiomyoma Through DEGs Screening and Networking.
Authors: UPADHYAY Sonal , RANI Anjali , DUBEY Pawan K. , BHUSHAN Ravi 
Published: May 2021

Abstract
Background: Uterine leiomyomas is a benign lesion arising in myometrium of the uterus. Various risk factors like stress, obesity, hormonal imbalance are involved in the progression of the uterine leiomyomas. Despite the significant research, the potential biomarkers related to uterine leiomyomas are yet to be discovered. Methods: The present study deals with searching the common potent markers of Uterine Leiomyoma (ULM) that was responsible for their pathogenicity. The microarray dataset (GSEID: GSE30673) was fetched through Gene Expression Omnibus database. Comparing with normal myometrium samples, Principal Component Analysis (PCA) and heat map were constructed to obtain differential expressed genes (DEGs) for ULM. Common DEGs were obtained through Venny software v 2.1.0. Significant enriched pathways and ontological study for DEGs were also performed through online Database for Annotation, Visualization and Integrated Discovery tool. Based upon STRING v 10.5, protein- protein interaction network was constructed in order to predict functional interactions among proteins. Results: 176 of total DEGs with 101 overexpressed and 75 under expressed genes were screened out with their official gene symbol. 2 DEGs were found as common genes in OMIM and Gene Cards.Only 9 DEGs were found to have combined score > 0.4 and hence included in interaction network. The present study revealed EGF, FYN, VCAN, TRIP13, FBXW7 as up-regulated genes and GATA2, JAG1, TLR3, APOL1 as down-regulated genes found to be expressed in samples with ULM disease. KEGG pathway enrichment analysis for DEGs revealed Focal adhesion, ECM-receptor interaction, long-term depression and Retinol metabolism are major pathways which have been enriched for these DEGs. Conclusion: We conclude that TRIP13 and TLR3 might be the novel biomarkers related to ULM disease which were revealed through our findings. The present study provides us a new perspective to detect the potent biomarkers responsible for ULM and further in vitro and in vivo experiments needed to be performed to verify the results.
Depth distribution of belowground net primary production across global biomes
Authors: Luo Zhongkui , Wang Guocheng , Xiao Liujun , Mao Xiali , Guo Xiaowei , Cowie Annette , Zhang Shuai , Wang Mingming , Chen Songchao , Zhang Ganlin , Shi Zhou 
Published: May 2021

Abstract
The depth distribution of belowground net primary production (BNPP) has been unquantified globally, hindering our understanding of belowground carbon dynamics. We synthesize global observational data sets to infer the depth allocation of BNPP down to 2 m, and map depth-specific BNPP globally at 1 km resolution. We estimate that global average BNPP in the 0–20 soil layer is 1.1 Mg C ha–1 yr–1, accounting for >50% of total BNPP. Across the globe, the depth distribution of BNPP shows large variability, and more BNPP is allocated to deeper layers in hotter and drier regions. Edaphic, climatic and topographic properties (in the order of importance) can explain >80% of such variability in different soil depths; and the direction and magnitude of the influence of individual properties (e.g., precipitation and soil nutrient) are soil depth- and biome-dependent. Our results provide global benchmarks for predictions of whole-soil carbon profiles across global biomes.
Arachidonic Acid Metabolites in Neurologic Disorders
Authors: Kursun Oguzhan , Karatas Hulya , Bariskaner Hulagu , Ozturk Serefnur 
Published: May 2021

Background & Objective:Arachidonic acid (ARA) is essential for the fluidity, selective permeability, and flexibility of the cell membrane. It is an important factor for the function of all cells, particularly in the nervous system, immune system, and vascular endothelium. ARA is the second most common polyunsaturated fatty acid in the phospholipids of the nerve cell membrane after docosahexaenoic acid. ARA metabolites have many kinds of physiologic roles. The major action of ARA metabolites is the promotion of the acute inflammatory response, mediated by the production of pro-inflammatory mediators such as PGE2 and PGI2, followed by the formation of lipid mediators, which have pro-resolving effects. Another important action of ARA derivatives, especially COX, is the regulation of vascular reactivity through PGs and TXA2. There is significant involvement of ARA metabolites in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and neuropsychiatric disorders. ARA derivatives also make an important contribution to acute stroke, global ischemia, subarachnoid hemorrhage, and anticoagulation-related hemorrhagic transformation.Conclusion:In this review, we have discussed experimental and human study results of neurologic disorders related to ARA and its metabolites in line with treatment options.
Usability of Rapid Cholera Detection Device (OmniVis) for Water Quality Workers in Bangladesh: Iterative Convergent Mixed Methods Study
Authors: Rager Theresa L , Koepfli Cristian , Khan Wasif A , Ahmed Sabeena , Mahmud Zahid Hayat , Clayton Katherine N 
Published: May 2021

Background
Cholera poses a significant global health burden. In Bangladesh, cholera is endemic and causes more than 100,000 cases each year. Established environmental reservoirs leave millions at risk of infection through the consumption of contaminated water. The Global Task Force for Cholera Control has called for increased environmental surveillance to detect contaminated water sources prior to human infection in an effort to reduce cases and deaths. The OmniVis rapid cholera detection device uses loop-mediated isothermal amplification and particle diffusometry detection methods integrated into a handheld hardware device that attaches to an iPhone 6 to identify and map contaminated water sources.

Objective
The aim of this study was to evaluate the usability of the OmniVis device with targeted end users to advance the iterative prototyping process and ultimately design a device that easily integrates into users’ workflow.

Methods
Water quality workers were trained to use the device and subsequently completed an independent device trial and usability questionnaire. Pretraining and posttraining knowledge assessments were administered to ensure training quality did not confound trial and questionnaire

Results
Device trials identified common user errors and device malfunctions including incorrect test kit insertion and device powering issues. We did not observe meaningful differences in user errors or device malfunctions accumulated per participant across demographic groups. Over 25 trials, the mean time to complete a test was 47 minutes, a significant reduction compared with laboratory protocols, which take approximately 3 days. Overall, participants found the device easy to use and expressed confidence and comfort in using the device independently.

Conclusions
These results are used to advance the iterative prototyping process of the OmniVis rapid cholera detection device so it can achieve user uptake, workflow integration, and scale to ultimately impact cholera control and elimination strategies. We hope this methodology will promote robust usability evaluations of rapid pathogen detection technologies in device development.
Mental Health Promotion and Stigma Reduction Among University Students Using the Reach, Efficacy, Adoption, Implementation, and Maintenance (RE-AIM) Framework: Protocol for a Mixed Methods Study
Authors: Fung Kenneth , Cheng Sheng-Li , Ning Xuan , Li Alan Tai-Wai , Zhang Jingxuan , Liu Jenny Jing-Wen , Hilario Carla T , Cheng Xiaojing , Yu Miao , Jia Cun-Xian , Gao Jianguo , Wong Josephine Pui-Hing 
Published: May 2021

Background
Rapid urbanization, academic pressures, and developmental life transition stressors contribute to mental health stress for postsecondary students in China. Effective prevention, early identification, and timely intervention are challenged by stigma, a lack of mental health literacy, and inadequate mental health resources.

Objective
Our implementation science (IS) research project is aimed at evaluating the use of an evidence-informed mental health promotion intervention named Acceptance and Commitment to Empowerment – Linking Youth and ‘Xin’ (hearts) (ACE-LYNX) to promote university student mental health in Jinan, China.

Methods
We will engage and collaborate with Shandong Mental Health Center, the provincial mental health center, and six local universities in different regions of Jinan. The ACE-LYNX intervention aims to reduce social stigma against mental illness, enhance mental health literacy, and improve access to quality mental health care by increasing interdisciplinary collaboration and forming a mental health network. It is based on two evidence-based approaches, Acceptance and Commitment Therapy (ACT) and Group Empowerment Psychoeducation (GEP), and it will be delivered through online learning and in-person group training. The project will train 90 interdisciplinary professionals using the model. They will in turn train 15 professionals and 20 students at each university. The project will adopt the Reach, Efficacy, Adoption, Implementation, and Maintenance (RE-AIM) framework, which provides a structure to examine the process and outcomes of implementation using mixed methods comprising quantitative and qualitative approaches along five dimensions: reach, efficacy, adoption, implementation, and maintenance.

Results
Over the course of the project, 720 champions will be directly trained. They will contribute to developing a formal and informal mental health network, strengthened by student-led mental health initiatives and professional-led initiatives to promote collaborative care and facilitated care pathways. We anticipate that our project will reach out to 11,000 to 18,000 students.

Conclusions
This IS protocol will outline our unique intervention model and key steps to contextualize, implement, and evaluate community-based mental health intervention.

International Registered Report Identifier (IRRID)
PRR1-10.2196/25592
THE STUDENTS’ RESPONSES TOWARD THE IMPLEMENTATION OF CROSSWORD PUZZLE IN TEACHING VOCABULARY TO THE SEVENTH GRADE STUDENTS IN ONE OF JUNIOR HIGH SCHOOL IN CIMAHI
Authors: Meliyani Yeni , Kareviati Evie 
Published: May 2021

This research was intended to find out the students’ responses toward the implementation of crossword puzzle techniques in teaching vocabulary to the seventh-grade students at Junior High School. A descriptive qualitative method was used in this study. In collecting data the researcher used two instruments: classroom observation throughout the implementation of crossword puzzle in the classroom and from students’ interviews. The researcher chose class VII B as respondents which consisted of 35 students. From the result, the researcher concluded that teaching-learning vocabulary by using crossword puzzle made the students’ easy to memorize the vocabulary and made the students’ more active in the class and the result also showed good responses from students, most of students felt interest and like to learn vocabulary in a descriptive text by using crossword puzzle.
Nurses’ Perceptions regarding Types of Aggressive Behaviour displayed by Patients in a Selected Psychiatric Hospital in Lesotho
Authors: Rathobei Libuseng Moureen , Nyangu Isabel , Dube Makhosazane 
Published: May 2021

Aggressive behaviour of inpatients in mental health facilities occurs globally and is a serious nursing problem. Consequently, there is insufficient research studies conducted among nurses regarding the types of aggressive behaviour displayed by patients in psychiatric institutions. The purpose of this study was to determine nurses’ perceptions regarding the types of aggressive behaviour displayed by patients in a selected psychiatric hospital in Lesotho. A quantitative descriptive survey was used to collect data from 119 nurses who were selected by quota sampling. The data were collected by means of a self-administered questionnaire, analysed by using SPSS (version 25), and displayed by using tables, frequencies, standard deviations, means and Pearson’s chi-square test. The findings reported that the types of aggressive behaviour included verbal aggression (86%, n = 103), physical aggression against objects (79%, n = 94), physical aggression against self (65.5%, n = 78), and physical aggression against other people (81.5%, n = 97). This study concludes that the perceptions of the nurses were positively inclined towards violent behaviour displayed by patients. The study recommends that nurses be equipped with comprehensive psychiatric skills and information to enable them to manage and cope with patients’ aggression.
Histopathological Study for the Effect of Ethanolic Extract of Sonchus Oleraceus on Escherichia Coli Bacteria in Mice
Authors: Alwan Mohammed J. 
Published: May 2021

This study was designed to explore the effect of the ethanolic extract of Sonchus oleraceus on Escherichia coli infection in mice. The LD50 of the orally dosage ethanolic extract of Sonchus oleraceus was found to be 800gm/kg B.W for two weeks. Twenty five mice were randomly divided into five groups. The first group was given orally the ethanolic extract with dose 800 mg/kg B.W for two weeks, then infected with Escherichia coli bacteria with dose 1×108 cfu for ten days. Second group was infected with Escherichia coli bacteria with dose 1×108 cfu for ten days then treated with ethanolic extract of Sonchus oleraceus for two weeks. The third group was infected only with Escherichia coli bacteria with a dose 1×108 cfu for ten days. Fourth group was given orally the ethanolic extract with a dose 800 mg/kg B.W orally for two weeks. Fifth group was given normal saline solution and serived as control The histopathological study showed pathological lesions in most of internal organs of the third group that infected with Escherichia coli bacteria specially liver, kidney and intestine. First group revealed lesions less than the third group, while the second group showed just aggregation of inflammatory cells in some internal organs and this refers that the ethanolic extract of Sonchus oleraceus have obvious inhibitory effect on Escherichia coli bacteria when compared with the infected group.
Lima 1535-2020: de la ciudad jardín a la megalópolis. Reflflexiones en el 485.° aniversario de su fundación española
Authors: Castillo García Rodolfo Francisco 
Published: May 2021

En este ensayo se ofrecen reflexiones acerca de la evolución de la ciudad de Lima desde la Lima colonial hasta la Lima megalópolis, y sobre la necesidad de su planificación urbana para promover el desarrollo urbano sostenible de la Megalópolis.
A drónelhárítás módszerei és lehetőségei
Authors: Dudás Zoltán , Ujvári Bence 
Published: May 2021

A szerzők bemutatják a távirányítású repülőgépes rendszerek jogszerűtlen alkalmazásából eredő veszélyforrásokat. Valós példákon keresztül illusztrálják a drónok rosszindulatú használatának veszélyeit. A lehetséges védekezési módok önmagukban nem elegendőek az ilyen felhasználásból adódó kockázatok lecsökkentésére, ám a rendelkezésre álló technológiák kombinálásával funkció és hatás szerint tagolt hatékony védelmi struktúra hozható létre.
Research on the Influence of Media Internalized Pressure on College Students’ Sports Participation—Chained Intermediary Analysis of Social Physique Anxiety and Weight Control Self-Efficacy
Authors: Ouyang Yiyi , Luo Jiong , Teng Jinsheng , Zhang Tingran , Wang Kun , Li Jing 
Published: May 2021

Purpose: Discuss the relationship among college students’ media internalized pressure, social physique anxiety, weight control self-efficacy, and sports participation in providing a reference for promoting college students to develop healthy and confident living habits.Methods: Take Southwest University in China as the object, select the subjects by stratified random sampling, and process the data with SPSS19.0 and AMOS21.0 statistical software.Results: (1) Media internalized pressure is positively correlated with social physique anxiety, weight control self-efficacy, and sports participation; social physique anxiety is significantly positively correlated with weight control self-efficacy and sports participation, and weight control self-efficacy is significantly positively correlated with sports participation; (2) media internalized pressure has a direct effect on sports participation (ES = 0.456), and social physique anxiety (ES = 0.136) and weight control self-efficacy (ES = 0.102) play significant mediating roles in the relationship between media internalized pressure and sports participation, respectively; the chained mediating force of social physique anxiety and weight control self-efficacy also reaches a significant level (ES = 0.027).Conclusion: Media internalized pressure can influence college students’ sports participation through the direct path as well as indirect paths such as social physique anxiety, the intermediary effect of weight control self-efficacy, and chained intermediary effect of social physique anxiety–weight control self-efficacy, and social physique anxiety is another key factor affecting college students’ sports participation except media internalized pressure.
Family Resilience, Parenting Styles and Psychosocial Adjustment of Children With Chronic Illness: A Cross-Sectional Study
Authors: Qiu Yuan , Xu Liuqing , Pan Yinzhu , He Chunlei , Huang Yingying , Xu Huan , Lu Zhongqiu , Dong Chaoqun 
Published: May 2021

Objectives: To evaluate the level of parent-reported family resilience, parenting styles and psychosocial adjustment of children with chronic illness and to identify the relationships between family resilience, parenting styles and psychosocial adjustment in families with children with chronic illness.Methods: A cross-sectional study was conducted between June 2019 and August 2019. A total of 236 parents of children with chronic illness and 98 parents with healthy children were recruited from general hospitals by convenience sampling. A parent completed the Chinese Family Resilience Assessment Scale, the Parenting Rearing Patterns Questionnaire and the Strengths and Difficulties Questionnaire. Family resilience, parenting styles, and psychosocial adjustment of children with chronic illness were compared with those of healthy children. Structural Equation Modeling (SEM) was performed to explore the mediation effect of parenting styles between family resilience and psychosocial adjustment among children with chronic illness.Results: Parents of children with chronic illness reported lower level of family resilience and authoritative parenting, but more peer relationship problems compared to parents of healthy children. SEM showed that authoritative parenting fully mediated the relationship between family resilience and psychosocial adjustment of children with chronic illness.Conclusion: Childhood chronic illness reduces family resilience, authoritative parenting and children's psychosocial adjustment, but authoritative parenting mediated these effects, so authoritative parenting may be important for family resilience in families of children with chronic illness. Pediatric clinicians and nurses should provide family-centered interventions, as well as parenting training, to improve children's psychosocial outcomes.
Exploring Three Recurrent Neural Network Architectures for Geomagnetic Predictions
Authors: Wintoft Peter , Wik Magnus 
Published: May 2021

Three different recurrent neural network (RNN) architectures are studied for the prediction of geomagnetic activity. The RNNs studied are the Elman, gated recurrent unit (GRU), and long short-term memory (LSTM). The RNNs take solar wind data as inputs to predict the Dst index. The Dst index summarizes complex geomagnetic processes into a single time series. The models are trained and tested using five-fold cross-validation based on the hourly resolution OMNI dataset using data from the years 1995–2015. The inputs are solar wind plasma (particle density and speed), vector magnetic fields, time of year, and time of day. The RNNs are regularized using early stopping and dropout. We find that both the gated recurrent unit and long short-term memory models perform better than the Elman model; however, we see no significant difference in performance between GRU and LSTM. RNNs with dropout require more weights to reach the same validation error as networks without dropout. However, the gap between training error and validation error becomes smaller when dropout is applied, reducing over-fitting and improving generalization. Another advantage in using dropout is that it can be applied during prediction to provide confidence limits on the predictions. The confidence limits increase with increasing Dst magnitude: a consequence of the less populated input-target space for events with large Dst values, thereby increasing the uncertainty in the estimates. The best RNNs have test set RMSE of 8.8 nT, bias close to zero, and linear correlation of 0.90.
UR_NLP @ HaSpeeDe 2 at EVALITA 2020: Towards Robust Hate Speech Detection with Contextual Embeddings
Authors: Hoffmann Julia , Kruschwitz Udo 
Published: May 2021

We describe our approach to address Task A of the EVALITA 2020 Hate Speech Detection (HaSpeeDe2) challenge. We submitted two runs that are both based on contextual embeddings – which we had chosen due to their effectiveness in solving a wide range of NLP problems. For our baseline run we use stacked embeddings that serve as features in a linear SVM. Our second run is a simple ensemble approach of three SVMs with majority voting. Both approaches outperform the official baselines by a large margin, and the ensemble classifier in particular demonstrates robust performance on different types of test data coming 6th (out of 27 runs) for news headlines and 10th (out of 27) for Twitter feeds.
Apresentação do Dossiê Temático "Amazônia, fronteiras e diversidades"
Authors: Rascke Karla Leandro , Veras Rogério De Carvalho , Costa Paulo Marcelo Cambraia da 
Published: May 2021

É imprescindível buscar reconstruir nossas representações sobre a Amazônia, se de fato desejamos colocá-la no centro do destino nacional e do equilíbrioclimático global. E isso passa certamente pelo exercício de uma pesquisa social que esteja seriamente comprometida em tentar ouvir os povos que habitam os territórios amazônicos. Reconfigurar nossas representações depende fundamentalmente de nos deixarmos impactar por esses lugares, seus saberes, suas histórias de resistências... é desarmar-se de nosso instrumental teórico forjado “de fora”, abolindo as hierarquias epistemológicas para nutrir-se das categorias e representações das pessoas que comvivem com as Amazônias. Assim sendo, povos e culturas, com suas formas e visões de mundo, produzem manifestações e caminhos de análise múltiplos. Seja no campo da História ou das demais Ciências Sociais, em crescente movimento de ampliar horizontes sobre as Amazônias,intelectuais têm se debruçado em análises sobre relações que permeiam sentidos e ênfases distintas. Em interfaces de tempos e espaços, desde concepções coletivas, comunitárias ou grupais, produzindo e transmitindo e culturas e saberes, em distintas linguagens, materialidades e espiritualidades, sujeitos históricos emergem em narrativas inovadoras sobre a região.