bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness Analysis of Abemaciclib Plus Fulvestrant in the Second-Line Treatment of Women With HR+/HER2– Advanced or Metastatic Breast Cancer: A US Payer Perspective
Authors: Wang Yingcheng , Rui Mingjun , Guan Xin , Cao Yingdan , Chen Pingyu 
Published: June 2021

Introduction:This study evaluated the cost-effectiveness of abemaciclib plus fulvestrant (ABE + FUL) vs. palbociclib plus fulvestrant (PAL + FUL), ribociclib plus fulvestrant (RIB + FUL) and fulvestrant monotherapy (FUL) as second-line treatment for hormone receptor-positive and human epidermal growth factor receptor 2- negative advanced or metastatic breast cancer in the US.Methods:The 3 health states partitioned survival (PS) model was used over the lifetime. Effectiveness and safety data were derived from the MONARCH 2 trial, MONALEESA-3 trial, and PALOMA-3 trial. Parametric survival models were used for four treatments to explore the long-term effect. Costs were derived from the pricing files of Medicare and Medicaid Services, and utility values were derived from published studies. Sensitivity analyses including one-way sensitivity analysis, probabilistic sensitivity analysis and scenario analysis were performed to observe model stability.Results:In the PS model, compared with PAL + FUL, ABE + FUL yielded 0.44 additional QALYs at an additional cost of $100,696 for an incremental cost-utility ratio (ICUR) of $229,039/QALY. Compared with RIB + FUL, ABE + FUL yielded 0.03 additional QALYs at an additional cost of $518 for an ICUR of $19,314/QALY. Compared with FUL, ABE + FUL yielded 0.68 additional QALYs at an additional cost of $260,584 for ICUR of $381,450/QALY. From the PS model, the ICUR was $270,576 /QALY (ABE + FUL vs. PAL + FUL), dominated (ABE + FUL vs. RIB + FUL) and $404,493/QALY (ABE + FUL vs. FUL) in scenario analysis. In the probabilistic sensitivity analysis, the probabilities that ABE + FUL was cost-effective vs. PAL + FUL, RIB + FUL and FUL at thresholds of $50,000, $100,000, and $200,000 per QALY gained were 0% and the probabilities that ABE + FUL was cost-effective vs. PAL + FUL and RIB + FUL at thresholds of $50,000, $100,000, and $200,000 per QALY gained were 0.2, 0.6, and 7.3%.Conclusions:The findings from the present analysis suggest that ABE + FUL might be cost-effective compared with RIB + FUL and not cost-effective compared with PAL + FUL and FUL for second-line treatment of patients with HR+/HER2– advanced or metastatic breast cancer in the US.
Effectiveness of the Auditory Temporal Ordering and Resolution Tests to Detect Central Auditory Processing Disorder in Adults With Evidence of Brain Pathology: A Systematic Review and Meta-Analysis
Authors: Chowsilpa Sanathorn , Bamiou Doris-Eva , Koohi Nehzat 
Published: June 2021

Background: Auditory temporal processing tests are key clinical measures in order to diagnose central auditory processing disorder (CAPD). Although these tests have been used for decades, there is no up-to-date evidence to determine the effectiveness of detecting the abnormalities in central auditory processing in adults while the available national CAPD guidelines predominantly address CAPD in the pediatric population.Purpose: To determine the efficacy of the auditory temporal ordering tests [duration pattern test (DPT) and frequency pattern test (FPT)], and a temporal resolution test [gaps-in-noise (GIN) test] for detecting the central auditory processing abnormalities in adults with documented brain pathology.Research Design: Systematic reviews and meta-analyses.Study samples: Four databases, including PubMed, Web of Science, Embase, and Scopus, were systematically searched. The publications in the English language that recruited adults (above 16 years old) with pathologic brain conditions and described the diagnostic tests for auditory temporal processing were selected for review.Data Collections and Analysis: All data were systematically evaluated, extracted, categorized, and summarized in tables. The meta-analysis was done in order to determine the effectiveness of the DPT, FPT, and GIN tests.Results: The results showed significantly poorer performance of DPT and FPT, compared between participants with confirmed brain disease and normal controls, at the mean differences of percent correct −21.93 (95% CI, −26.58 to −17.29) and −31.37 (95% CI, −40.55 to −22.19), respectively. Subjects with brain pathology also performed poorer in GIN test at the mean difference of 3.19 milliseconds (95% CI, 2.51 to 3.87).Conclusion: The results from the meta-analysis provide evidence that DPT, FPT, and GIN clinical measures are effective in the diagnosis of CAPD in adults with neurological disorders. Poor performance on these tests is significantly related to the confirmed brain pathology. However, different units in results presentation and variety of testing strategies are limitations for this meta-analysis. The standard pattern of result reporting and international protocols test strategies should be developed in order to conduct better meta-analyses with a larger collection of suitable studies and less heterogeneity.
A Nomogram for Predicting Survival in Patients With Breast Cancer Liver Metastasis: A Population-Based Study
Authors: Xiong Yu , Shi Xia , Hu Qi , Wu Xingwei , Long Enwu , Bian Yuan 
Published: June 2021

ObjectiveThe prognosis of patients with breast cancer liver metastasis (BCLM) was poor. We aimed at constructing a nomogram to predict overall survival (OS) for BCLM patients using the SEER (Surveillance Epidemiology and End Results) database, thus choosing an optimized therapeutic regimen to treat.MethodsWe identified 1173 patients with BCLM from the SEER database and randomly divided them into training (n=824) and testing (n=349) cohorts. The Cox proportional hazards model was applied to identify independent prognostic factors for BCLM, based on which a nomogram was constructed to predict 1-, 2-, and 3-year OS. Its discrimination and calibration were evaluated by the Concordance index (C-index) and calibration plots, while the accuracy and benefits were assessed by comparing it to AJCC-TNM staging system using the decision curve analysis (DCA). Kaplan-Meier survival analyses were applied to test the clinical utility of the risk stratification system.ResultsGrade, marital status, surgery, radiation therapy, chemotherapy, CS tumor size, tumor subtypes, bone metastatic, brain metastatic, and lung metastatic were identified to be independent prognostic factors of OS. In comparison with the AJCC-TNM staging system, an improved C-index was obtained (training group: 0.701 vs. 0.557, validation group: 0.634 vs. 0.557). The calibration curves were consistent between nomogram-predicted survival probability and actual survival probability. Additionally, the DCA curves yielded larger net benefits than the AJCC-TNM staging system. Finally, the risk stratification system can significantly distinguish the ones with different survival risk based on the different molecular subtypes.ConclusionWe have successfully built an effective nomogram and risk stratification system to predict OS in BCLM patients, which can assist clinicians in choosing the appropriate treatment strategies for individual BCLM patients.
Continuous Complete Remission in Two Patients with Acute Lymphoblastic Leukemia and Severe Fungal Infection Following Short-Term, Dose-Reduced Chemotherapy
Authors: Lüke Florian , Harrer Dennis C. , Hahn Joachim , Grube Matthias , Pukrop Tobias , Herr Wolfgang , Reichle Albrecht , Heudobler Daniel 
Published: June 2021

Spontaneous remission in acute lymphoblastic leukemia (ALL) is a rare phenomenon, which typically involves a pattern of feverish or septic disease followed by quick but mostly transient remission. We report on two male patients (46-year-old (pt. 1) and 19-year-old (pt. 2)) with CD20 positive, BCR-ABL negative common B-ALL. Patient 1 had received dexamethasone and cyclophosphamide (1.2 g) as a prephase therapy, followed by rituximab and a cumulative dose of 200 mg daunorubicin combined with 2 mg vincristine as an induction therapy. Patient 2 was treated with a reduced therapy regimen (Vincristine 1 mg, dexamethasone and 80 mg daunorubicin, 12-month mercaptopurine maintenance) due to (alcohol-related) toxic liver failure and pontine myelinolysis. Both patients developed severe septic disease just few days into induction treatment. Patient 1 suffered from pulmonary mycosis, which had to be resected eventually. Histological work-up revealed invasive mucor mycosis. Patient 2 presented with elevated serum aspergillus antigen and radiographic pulmonary lesions, indicative of pulmonary mycosis. In both patients, chemotherapy had to be interrupted and could not be resumed. Both patients recovered under broad antimicrobial, antifungal and prophylactic antiviral therapy and achieved molecular complete remission. At data cut-off remissions had been on-going for 34 months (pt. 1) and 8 years (pt. 2). Short-term, reduced intensity induction chemotherapy accompanied by severe fungal infections was followed by long-lasting continuous complete remissions in ALL. Thus, we hypothesize that infection-associated immunogenic responses may not only prevent early relapse of ALL but could also eradicate minimal residual disease. The effects of combined cytotoxic therapy and severe infection may also be mimicked by biomodulatory treatment strategies aiming at reorganizing pathologically altered cellular signaling networks. This could reduce toxicity and comorbidity in adult patients requiring leukemia treatment. Therefore, these two cases should encourage systematic studies on how leukemia stroma interaction can be harnessed to achieve long lasting control of ALL.
Case Report: Dynamic Interdependencies Between Complementary and Alternative Medicine (CAM) Practice, Urinary Interleukin-6 Levels, and Fatigue in a Breast Cancer Survivor
Authors: Singer Magdalena , Ott Michaela , Bliem Harald R. , Hladschik-Kermer Birgit , Ocaña-Peinado Francisco M. , Chamson Emil , Schubert Christian 
Published: June 2021

Background: This study investigated the influence of complementary and alternative medicine (CAM) techniques (i.e., Jin Shin Jyutsu, music, physiotherapy, Tai Chi, and energy healing) on urinary interleukin-6 (IL-6) levels and fatigue in a 49-year-old breast cancer survivor suffering from cancer-related fatigue and depression. Data were sampled under conditions of “life as it is lived.”Methods: For 28 days, a female breast cancer survivor collected her full urine output in 12-h intervals from about 8 a.m. to 8 p.m. and from about 8 p.m. to 8 a.m. These urine samples were used to determine urinary IL-6 levels through ELISA and creatinine concentrations via HPLC. In 12-h intervals (every morning and evening), the patient completed the DIARI, which included fatigue measurement and notes on incidents and activities such as CAM practice. In addition, the patient was interviewed weekly to identify meaningful everyday incidents. In this context, CAM practice was also discussed. Time series analysis consisted of ARIMA modeling and cross-correlational analyses (p &lt; 0.05).Results: When each CAM technique was considered separately in time series analysis, CAM was consistently associated with increases in urinary IL-6 release and decreases in fatigue. Furthermore, when all CAM techniques experienced as positive were included in one time series, a biphasic urinary IL-6 response pattern was found in which CAM practice was first preceded by decreases in IL-6 by 12–0 h and then followed by increases in IL-6 after 108–120 h. Finally, cross-correlations between IL-6 and fatigue showed that increases in IL-6 were followed by decreases in fatigue intensity after 48–60 h and, conversely, that decreases in fatigue intensity were followed by decreases in IL-6 after 24–36 h and 48–60 h.Conclusion: IL-6 increases and fatigue decreases highlight potential health-promoting effects of CAM practice. Moreover, a cyclic IL-6 pattern in response to all CAM activities experienced as positive underscores that CAM was meaningful to the patient. Additionally, a negative feedback circuit between IL-6 and fatigue intensity was detected. Taken together, this study confirms the necessity of integrating subjective meaning and dynamic complexity into biopsychosocial research in order to understand human functioning under real-life conditions.
Outcomes and Complications of Bipolar vs. Monopolar Energy for Transurethral Resection of Bladder Tumors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Mao Xin , Zhou Zhongbao , Cui Yuanshan , Zhang Yong , Yang Mingshan 
Published: June 2021

Background:Bipolar and monopolar transurethral resections have a stable status for non-muscle invasive bladder cancer (NMIBC). We conducted a meta-analysis to analyze the outcomes and complications of bipolar vs. monopolar energy for transurethral resection of bladder tumors (TURB).Methods:The Preferred Reporting Items for Systematic Reviews and Meta-analyses was followed. Based on the Population, Intervention, Comparator, Outcomes, and Study Designs (PICOS) strategy, randomized controlled trials were searched in MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the associated articles were also retrieved. The data were calculated by Rev Man v5.3.0.Results:Eleven publications containing an amount of 2, 099 patients were involved in the study. Two groups did not show a significant difference in the mean age and the number of bladder tumors. The results showed that m-TURB had a greater decrease in postoperative hemoglobin level [mean difference (MD) −0.26, 95% confidence interval (CI) −0.48 to −0.04,P= 0.02] and sodium level (MD −0.36, 95% CI −0.62 to −0.10,P= 0.007) compared with b-TURB. B-TURB spent relatively little in hospitalization time (MD −0.52, 95% CI −0.88 to −0.15,P= 0.005) than m-TURB with the exception of operation time (P= 0.47) and catheterization time (P= 0.19). B-TURB did not show a significant difference in the incidence rate of obturator reflex (P= 0.10), bladder perforation (P= 0.32), postoperative blood transfusion (P= 0.28), and clot retention (P= 0.21) compared with the b-TURB group. Besides, there were no significant difference in terms of muscle tissue sampling (P= 0.43), recurrence-free survival at 6 months (P= 0.68) and 12 months (P= 0.78).Conclusions:B-TURB was more effective than m-TURB in minimizing intraoperative or postoperative bleeding with the smaller loss of hemoglobin and the shorter hospitalization time for patients with NMIBC.
Acceleration of boundary element calculations for closed domain using nonlinear form functions and CUDA technology
Authors: Sherbakov S. S. , Polestchuk M. M. 
Published: June 2021

The evolution of computer technologies, as a hardware and a software parts, allows to attain fast and accurate solutions to many applied problems in scientific areas. Acceleration of calculations is broadly used technic that is basically implemented by multithreading and multicore processors. NVidia CUDA technology or simply CUDA opens a way to efficient acceleration of boundary elements method (BEM), that includes many independent stages. The main goal of the paper is implementation and acceleration of indirect boundary element method using three form functions. Calculation of the potentialdistribution inside a closed boundary under the action of the defined boundary condition is considered. In order to accelerate corresponding calculations, they were parallelized at the graphic accelerator using NVidia CUDA technology. The dependences of acceleration of parallel computations as compared with sequential ones were explored for different numbers of boundary elements and computational nodes. A significant acceleration (up to 52 times) calculation of the potential distribution without loss in accuracy is shown. Acceleration of up to 22 times was achieved in calculation of mutual influence matrix for boundary elements. Using CUDA technology allows to attain significant acceleration without loss in accuracy and convergence. So application of CUDA is a good way to parallelizing BEM. Application of developed approach allows to solve problems in different areas of physics such as acoustics, hydromechanics, electrodynamics, mechanics of solids and many other areas, efficiently.
The world-wide spread of carbapenem-resistant Enterobacterales
Authors: TAMBIC ANDRASEVIC Arjana , ANTAL ANTUNOVIC Ivana 
Published: June 2021

Introduction. Gram-negative bacilli belonging to the order Enterobacterales are normal inhabitants of the human gut, which also are the most common causative agents of both nosocomial and community-acquired infections in patients of all ages. Although not even a century has passed since Fleming's discovery of penicillin, the scientists have been alarmed by the fact that the "last resort antibiotics" viz. carbapenems have been compromised.
Material and methods. The analysis of fifty-two articles and documents regarding this topic was performed.
Results. The main mechanism of resistance to carbapenems in Enterobacterales is the production of carbapenemases, being enzymes that destroy all or almost all β-lactam antibiotics including carbapenems. According to Ambler’s classification β-lactamases can be distributed into four classes (A, B, C, and D) being based on primary amino acid sequence homology. The most important carbapenemases produced by Enterobacterales belong to class A (KPC), class B (metallo-β-lactamases NDM, VIM, IMP) and class D (OXA-48-like). Unlike other mechanisms of resistance, carbapenemase production is easily spread via plasmids making carbapenemase-producing Enterobacterales (CPE) a global challenge for healthcare providers.
Conclusions. CPE is not readily detected in the laboratory but the ability to detect carbapenemase production in Enterobacterales has very important infection control implications and therefore is essential for local infection control programs and national and international surveillance systems. Furthermore, local epidemiology of multidrug-resistant organisms has a major influence on the development of national clinical guidelines for antimicrobial use.
Storms, Variability, and Multiple Equilibria on Hot Jupiters
Authors: Cho James Y-K. , Skinner Jack W. , Thrastarson Heidar Th. 
Published: June 2021

Abstract
Observations of hot-Jupiter atmospheres show large variations in the location of the “hot spot” and the amplitude of spectral features. Atmospheric flow simulations using the commonly employed forcing and initialization have generally produced a large, monolithic patch of nearly stationary hot area located eastward of the substellar point at high altitude. Here we perform high-resolution (T682) pseudospectral simulations that accurately capture small-scale eddies and waves inherent in hot-Jupiter atmospheres due to ageostrophy. The atmospheres contain a large number of intense storms over a wide range of scales, including the planetary scale. The latter sized storms dictate the large-scale spatial distribution and temporal variability of hot, as well as cold, regions over the planet. In addition, they exhibit quasi-periodic life cycles within multiple equilibrium states—all identifiable in the disk-integrated time series of the temperature flux.
La haine : une passion actuelle. Questions à l’anthropologie clinique
Authors: Douville Olivier , Le Fourn Jean-Yves , Lauru Didier 
Published: June 2021

Olivier Douville, Jean-Yves Le Fourn et Didier Lauru s’accordent sur cela que la haine est une notion-clé en psychanalyse qui doit être envisagée autrement que comme l’envers de l’amour. Une haine primordiale est au service de l’autoconservation d’un moi idéal, et « purifié » hostile à toute intrusion par l’étranger et l’altérité. Cette définition, qui éclaire les racines inconscientes de la haine, permet également de théoriser les solutions sociales qui incitent à conserver cet idéal d’une pureté cruelle. L’apport de la psychanalyse à l’anthropologie serait bien de situer les irruptions et les variations de cette passion dans le rapport du sujet à ses croyances et à ses allégeances et dans ses volontés de faire Un avec un groupe, un idéal, une cause. Observant la sensibilité et l’appétence des adolescents vivant en des temps de tourments et de violence extrême pour les affiliations valorisant la haine, et alertés en ceci que cette haine est une passion froide (à l’inverse de la jalousie), les auteurs élaborent des hypothèses sur les liens ente haine, honte et « mélancolisation du lien social ».
Arthur Rimbaud et sa « Mother ». Fragments de discours de haine
Authors: Le Fourn Jean-Yves 
Published: June 2021

Rimbaud, le poète, le « voyant », fut tout au long de sa vie, de l’enfance à l’âge adulte, en passant par son adolescence, accompagné par la Haine. Haine envers ses origines, Haine de l’injustice, Haine dans ses relations personnelles, la haine fut le vrai compagnon de sa vie. La haine lui a été « utile », tant dans sa vie de poète, que d’homme. Elle fut son « sentiment de lucidité », mais aussi sa « saison en enfer » permanente.
L’errance de Fabien : mélancolisation de la haine et culture populaire
Authors: Sylla Arnaud 
Published: June 2021

Si l’adolescent, en tant que construction sociale, n’est pas attendu pour ce qu’il est en devenir mais pour ce qu’il produit comme angoisses projectives du corps social, comment dès lors le sujet pris dans ce processus peut-il attraper des signifiants nouveaux pour se démarquer et se singulariser ? Le récit clinique de la rencontre d’un adolescent en marge de lien social nous permettra d’interroger la place des objets de culture dans un processus adolescent en impasse. La haine et le trauma y figurent comme éléments structurels des mangas de type Shonen , lesquels serviront de trame dans le cheminement thérapeutique. La culture sera envisagée au service d’une restauration du lien social en soutenant un processus d’individuation et donc une capacité à se séparer en sécurité.
Numérique et innovations pédagogiques en sciences de gestion : résultats de recherches
Authors: Chevalier Françoise , Fournier Christophe 
Published: June 2021

Cet éditorial est une introduction au dossier spécial « Numérique et innovations pédagogiques en sciences de gestion : résultats de recherches ». Outre le fait de présenter les 3 articles retenus suis au processus scientifique, les rédacteurs en chef invités font le point sur l’innovation pédagogique notamment numérique, aux enjeux majeurs et stratégiques pour nos institutions, et ce, indépendamment de la crise sanitaire actuelle. Cet éditorial s’articule autour de trois points. Le premier rappelle la difficulté de mener des recherches dans le domaine des innovations pédagogiques numériques, tant le domaine est foisonnant et ses contours mouvants. Le deuxième est consacré à la variété des innovations pédagogiques numériques mises en œuvre et soulève l’épineuse question des modes d’évaluation de ces innovations. Enfin, le troisième point introduit les articles présentés dans ce dossier qui, chacun dans un domaine (marketing/vente, comptabilité/contrôle et ressources humaines), relate les résultats de recherche sur la mise en œuvre d’innovations pédagogiques faisant appel au numérique.