bluuebunny/crossref_metadata_2025_split huggingface dataset:
S3-Leitlinie Sauerstoff in der Akuttherapie beim Erwachsenen
Authors: Gottlieb Jens , Capetian Philipp , Hamsen Uwe , Janssens Uwe , Karagiannidis Christian , Kluge Stefan , König Marco , Markewitz Andreas , Nothacker Monika , Roiter Sabrina , Unverzagt Susanne , Veit Wolfgang , Volk Thomas , Witt Christian , Wildenauer René , Worth Heinrich , Fühner Thomas 
Published: September 2021

Zusammenfassung
Hintergrund Sauerstoff (O2) ist ein Arzneimittel mit spezifischen biochemischen und physiologischen Eigenschaften, einem definierten Dosis-Wirkungsbereich und mit unerwünschten Wirkungen. Im Jahr 2015 wurden 14 % von über 55 000 Krankenhauspatienten in Großbritannien mit O2 behandelt. Nur 42 % der Patienten hatten dabei eine O2-Verordnung. Gesundheitspersonal ist oft unsicher über die Relevanz einer Hypoxämie, und es besteht ein eingeschränktes Bewusstsein für die Risiken einer Hyperoxämie. In den letzten Jahren wurden zahlreiche randomisierte kontrollierte Studien zu Zielen der Sauerstofftherapie veröffentlicht. Eine nationale Leitlinie ist deswegen dringend erforderlich.
Methoden Im Rahmen des Leitlinienprogramms der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. V. (AWMF) wurde unter Beteiligung von 10 Fachgesellschaften eine S3-Leitlinie entwickelt und im Juni 2021 veröffentlicht. Bis zum 1. 2. 2021 wurde eine Literaturrecherche durchgeführt, um 10 Schlüsselfragen zu beantworten. Zur Klassifizierung von Studientypen hinsichtlich ihrer Validität wurde das Oxford Centre for Evidence-Based Medicine (CEBM) System („The Oxford 2011 Levels of Evidence“) verwendet. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) wurde verwendet und zur Bewertung der Evidenzqualität und zur Einstufung von Leitlinienempfehlungen wurde ein formaler Konsensbildungsprozess durchgeführt.
Ergebnisse Die Leitlinie enthält 34 evidenzbasierte Empfehlungen zu Indikation, Verordnung, Überwachung und Abbruch der Sauerstofftherapie in der Akutversorgung. Die Hauptindikation für die O2-Therapie ist Hypoxämie. In der Akutmedizin sollten sowohl Hypoxämie als auch Hyperoxämie vermieden werden. Hyperoxämie scheint mit einer erhöhten Sterblichkeit verbunden zu sein, insbesondere bei Patienten mit Hyperkapnie. Die Leitlinie empfiehlt Zielsauerstoffsättigung für die Akuttherapie mit O2 ohne Differenzierung zwischen Diagnosen. Zielbereiche sind abhängig vom Hyperkapnierisko und Beatmungsstatus. Die Leitlinie bietet einen Überblick über verfügbare Sauerstoffzufuhrsysteme und enthält Empfehlungen für deren Auswahl basierend auf Patientensicherheit und -komfort.
Fazit Dies ist die erste nationale Leitlinie zum Einsatz von Sauerstoff in der Akutmedizin. Sie richtet sich an medizinisches Fachpersonal, das Sauerstoff außerklinisch und stationär anwendet. Sie ist bis zum 30. 06. 2024 gültig.
Herbal Medicines in the Treatment of Dyspepsia: An Overview
Authors: Boeing Thaise , de Souza Priscila , da Silva Luisa Mota , Gasparotto Junior Arquimedes 
Published: September 2021

AbstractThis review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The
data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.
An in-depth look into a well-known herbal drug: Fingerprinting, isolation, identification, and content estimation of saponins in different Strophanthus seeds
Authors: Włodarczyk Maciej , Gleńsk Michał 
Published: September 2021

AbstractSeeds of Strophanthus species are known as a source of rapid-acting cardenolides. These water-soluble glycosides are listed as the sole critical constituents of this raw herbal drug. A non-standard cardioprotective medication with ouabain-containing oral remedies has become popular in Europe as a result of the withdrawal of corresponding registered drugs from the market. However, the bioequivalence of pure ouabain solutions, tinctures, and home-made extracts from Strophanthus seeds is unknown. Thus, this study aimed to update the information on the composition of Strophanthus seeds used for this purpose. The distribution of two main saponins and about 90 previously unreported compounds, tentatively identified as saponins in eleven Strophanthus species, was systematically evaluated by ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS) and -MS/MS. Seeds of S. gratus were selected to isolate the dominant unreported
triterpenoids, bidesmosides of echinocystic and oleanolic acid. Their structures were established by HRMS, MS/MS, as well as by NMR techniques. The total saponin content, estimated by UHPLC-MS, was up to 1%. The detected saponins could influence the peroral bioavailability of hardly absorbable Strophanthus cardenolides and exhibit their own activity. This finding may be relevant when Strophanthus preparations (containing both saponins and cardiac glycosides) are used, particularly when homemade preparations are administered.
Domino Reactions of Chromones with Heterocyclic Enamines
Authors: Langer Peter 
Published: September 2021

AbstractDomino reactions of heterocyclic enamines with chromone derivatives provides a convenient synthesis of a great variety of annulated heterocyclic ring systems. The course of the reaction depends on the type of substituent located at position 3 of the chromone. Reactions of 3-unsubstituted chromones, 3-nitrochromones, and 3-halochromones proceed by conjugate addition of the carbon atom of the enamine to carbon C-2 of the chromone, ring cleavage, and recyclization via the chromone carbonyl group. In the case of 3-formylchromes, 3-dichloroacetylchromone, 3-perfluoroalkanoylthiochromones, 3-(2-fluorobenzoyl)chromones, and 3-methoxalylchromones the final cyclization proceeds via the carbonyl group located outside the chromone moiety. The functional groups located at the carbonyl group at position 3 of the chromone allow for further synthetic transformations including additional ring closures.Contents1 Introduction2 3-Unsubstituted Chromones3 3-Nitrochromones4 3-Formylchromes5 3-Dichloroacetylchromone6 3-Perfluoroalkanoylthiochromones7 3-Methoxalylchromones8 3-(2-Fluorobenzoyl)chromones9 3-Halochromones10 Chromone-3-carboxylic Acids11 Conclusions
Red Blood Cell Transfusion and its Relationship with Pedicle Thrombosis in Microvascular Free Flaps
Authors: Torres Fuentes Carlos Eduardo , Rodríguez Mantilla Iván Enrique , Cáceres Diego Nicolás Guerrero , Camargo Gonzalez Diego Felipe 
Published: September 2021

Abstract
Background Free flaps have become a highly valuable tool for complex reconstructive surgeries. The requirement of red blood cell transfusion (RBCT) during the perioperative period is common and its effect on the free flap survival is debatable. The aim of this study was to determine the relationship between perioperative RBCT and vascular pedicle thrombosis (VPT).
Methods For this study 302 free flaps performed between January 2006 and December 2019 were retrospectively analyzed. It included their characteristics from before, during, and after the surgical procedure. The incidence of VPT and flap survival were calculated based on Kaplan Meier's method and the relationship between VPT and perioperative variables were analyzed by Cox regression models.
Results The transfusion group was represented by 62 flaps (20.5%) and no transfusion by 240 flaps. The overall transfusion requirement was 20.5% and the cumulative incidence of VPT was 9.11%. A statistically significant relationship was not demonstrated between flap survival and transfusion status (HR = 1.73 IC 95%: 0.5 to 3.96; p = 0.192) (p = 0.192) independently from the number of units transfused, the preoperative diagnosis of anemia, and the type of flap used and did not establish an increased risk of VPT.
Conclusion This study did not demonstrate an association between RBCT during preoperative period and the risk for VPT or microvascular free flap survival rate on postoperative follow up.
Efficient Synthesis and Docking Analysis of Selective CDK9 Inhibitor NVP-2
Authors: Saidahmatov Abdusaid , Liang Xue-Wu , Shi Yu-Qiang , Han Xu , Liu Hong 
Published: September 2021

Graphical AbstractNVP-2 (1), a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), showed potent antitumor activity in preclinical studies. In this work, we designed and adopted a convergent synthetic route to efficiently synthesize NVP-2 (1). The key intermediate (7) was synthesized from malononitrile (2) and 1-bromo-2-(2-bromoethoxy)ethane (3) by successive cyclization, reduction, nucleophilic substitution with 2-bromo-6-fluoropyridine, and Suzuki–Miyaura reaction with (5-chloro-2-fluoropyridin-4-yl)boronic acid. Another key intermediate (11) was synthesized from (S)-1-methoxypropan-2-ol (8) by reaction with TsCl, electrophilic substitution reaction with tert-butyl ((1r,4r)-4-aminocyclohexyl)carbamate, and then by deprotection of Boc. Finally, a substitution reaction by the key intermediates (7) and (11) to afford the target product NVP-2 (1). The reaction conditions of the whole synthesis process were simple and mild, free of harsh conditions such as the microwave reaction and dangerous reagents in the original patent, and realized the efficient synthesis of NVP-2. In addition, we analyzed the binding mode of NVP-2 in the active pocket of CDK9 to provide reasonable design ideas for subsequent discovery of novel CDK9 inhibitors.
Strategies and Applications of Antigen-Binding Fragment (Fab) Production in Escherichia coli
Authors: Chen Hui , Chen Jun-Sheng , Paerhati Pameila , Jakos Tanja , Bai Si-Yi , Zhu Jian-Wei , Yuan Yun-Sheng 
Published: September 2021

AbstractWith the advancement of genetic engineering, monoclonal antibodies (mAbs) have made far-reaching progress in the treatment of various human diseases. However, due to the high cost of production, the increasing demands for antibody-based therapies have not been fully met. Currently, mAb-derived alternatives, such as antigen-binding fragments (Fab), single-chain variable fragments, bispecifics, nanobodies, and conjugated mAbs have emerged as promising new therapeutic modalities. They can be readily prepared in bacterial systems with well-established fermentation technology and ease of manipulation, leading to the reduction of overall cost. This review aims to shed light on the strategies to improve the expression, purification, and yield of Fab fragments in Escherichia coli expression systems, as well as current advances in the applications of Fab fragments.
In Vitro PIG-A Gene Mutation Assay in Human B-Lymphoblastoid TK6 Cells
Authors: Zhou Chang-Hui , Yu Chun-Rong , Huang Peng-Cheng , Li Ruo-Wan , Wang Jing-Ting , Zhao Tian-Tian , Zhao Ze-Hao , Ma Jing , Chang Yan 
Published: September 2021

AbstractThe X-linked PIG-A gene is involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. PIG-A mutant cells fail to synthesize GPI and to express GPI-anchored protein markers (e.g., CD59 and CD55). In recent years, in vitro PIG-A assay has been established based on the high conservation of PIG-A/Pig-a loci among different species and the large data from the in vivo system. The purpose of this study was to extend the approach for PIG-A mutation assessment to in vitro human B-lymphoblastoid TK6 cells by detecting the loss of GPI-linked CD55 and CD59 proteins. TK6 cells were treated with three mutagens 7,12-dimethylbenz[a]anthracene (DMBA), N-ethyl-N-nitrosourea (ENU), etoposide (ETO), and two nonmutagens: cadmium chloride (CdCl2) and sodium chloride (NaCl). The mutation rate of PIG-A gene within TK6 cells was determined on the 11th day with flow cytometry analysis for the negative frequencies of CD55 and CD59. The antibodies used in this production were APC mouse-anti-human CD19 antibody, PE mouse anti-human CD55 antibody, PE mouse anti-human CD59 antibody, and nucleic acid dye 7-AAD. An immunolabeling method was used to reduce the high spontaneous level of preexisting PIG-A mutant cells. Our data suggested that DMBA-, ENU-, and ETO-induced mutation frequency of PIG-A gene was increased by twofold compared with the negative control, and the effects were dose-dependent. However, CdCl2 and NaCl did not significantly increase the mutation frequency of PIG-A gene, with a high cytotoxicity at a dose of 10 mmol/L. Our study suggested that the novel in vitro PIG-A gene mutation assay within TK6 cells may represent a complement of the present in vivo Pig-a assay, and may provide guidance for their potential use in genotoxicity even in cells with a significant deficiency of GPI anchor.
Fingerprint building and positioning based on wireless sensor networks for underground
Authors: Cui Lizhen , Yang Yong , Wang QiaoLi , Xu FanFei , Guo Qianqian 
Published: September 2021

This paper proposes an algorithm of fingerprint constructing and positioning based on wireless sensor networks. The positioning area of underground is divided into several sub-areas according to the neighborhood principle. The reliability mechanism based on the calibration node is established in each sub-area, and the availability of the reference point fingerprint is later determined by the reliability mechanism of the sub-area. When the fingerprint data of the sub-region reference point changes too much, the neighborhood mapping fingerprint model trained by the back propagaption neural network is used to construct the fingerprint. The principle of the neighborhood mapping model is to train the neighborhood relationship between each reference point and its adjacent calibration node in the offline phase to form a network model structure. Then, we use this model to build the fingerprint of reference point in the online stage. In the real-time positioning stage, we use the positioning model based on the adaptive network-based fuzzy inference system. The average positioning error of our proposed algorithm is 3.03 m, when there is a seven day interval between the training dataset and testing dataset, which confirms that the proposed algorithm can be better adapted to the changing environment and to achieve better positioning results.
Holmium (Ho) oxide, carbide, and dioxide cation bond energies and evaluation of the Ho + O → HoO+ + e− chemi-ionization reaction enthalpy
Authors: Owen Cameron J. , Kim JungSoo , Armentrout P. B. 
Published: September 2021

Guided ion beam tandem mass spectrometry (GIBMS) and quantum chemical calculations are employed to evaluate the title chemi-ionization reaction with holmium. Exchange reactions of Ho+ with O2, CO, and SO2 and HoO+ with CO, as well as collision-induced dissociation (CID) reactions of HoO+ with Xe, O2, and CO, were performed using GIBMS. Formation of HoO+ is exothermic in reactions with O2 and SO2 but endothermic for reaction with CO, as is the exchange reaction of HoO+ with CO. Quantitative analysis of these reactions and the three CID reactions provides a robust method to determine the bond dissociation energy (BDE) of Ho+–O, 6.02 ± 0.13 eV. BDEs for Ho+–C and OHo+–O are also measured as 2.27 ± 0.19 and 2.70 ± 0.27 eV, respectively. All three measurements are the first direct determinations of these BDEs. By combining the BDE of HoO+ with the well-established ionization energy of Ho, the exothermicity of Ho in the title chemi-ionization reaction can also be obtained as 0.00 ± 0.13 eV. All experimental thermochemistry was then compared to quantum chemical calculations for the purpose of establishing benchmarks and validation. BDEs determined via these calculations are in agreement with the experiment within the inherent experimental and theoretical uncertainties, with results obtained at the coupled-cluster with single, double, and perturbative triple excitations, CCSD(T), using all-electron basis sets yielding the most accurate results.
Translation hacking in Arabic video game localization
Authors: Al-Batineh Mohammed , Alawneh Razan 
Published: September 2021

AbstractThe present article discusses the notion of translation hacking and attempts to chart the history of this practice in the Arabic context. It also discusses the current practices of translation hacking by examining the work of a well-organized online community of Arab translation hackers calledGames in Arabic(GiA). To this end, the study adopts two methods for data collection. First, semi-structured interviews were conducted with the first translation hackers in the Arab world in order to document the history of this practice. Second, a cyberethnographic approach was adopted to collect qualitative data related to GiA, including their translation hacking practices and the technologies used to facilitate their collaborative work. Subsequently, this article attempts to reveal the roles played by the different GiA community members in executing their projects and how they control for quality in their work. Ultimately, the article attempts to provide insights into the practice of Arabic game localization performed by amateur translators, hackers, and gamers, in the hope of adding to current professional and pedagogical practices in Arabic game localization.
Soft congestion approximation to the one-dimensional constrained Euler equations
Authors: Bianchini Roberta , Perrin Charlotte 
Published: September 2021

Abstract
This article is concerned with the analysis of the one-dimensional compressible Euler equations with a singular pressure law, the so-called hard sphere equation of state. We provide a detailed description of the effect of the singular pressure on the breakdown of the smooth solutions. Moreover, we rigorously justify the singular limit for smooth solutions towards the free-congested Euler equations, where the compressible (free) dynamics is coupled with the incompressible one in the constrained (i.e. congested) domain.
Thermal quench and current profile relaxation dynamics in massive-material-injection-triggered tokamak disruptions
Authors: Nardon E , Hu D , Artola F J , Bonfiglio D , Hoelzl M , Boboc A , Carvalho P , Gerasimov S , Huijsmans G , Mitterauer V , Schwarz N , Sun H , JOREK team the 
Published: September 2021

Abstract
3D non-linear magnetohydrodynamic simulations of a disruption triggered by a massive injection of argon gas in JET are performed with the JOREK code. The key role of the thermal drive of the m = 2, n = 1 tearing mode (i.e. the drive from helical cooling inside the island) in the disruption process is highlighted by varying the amplitude and position of the argon source across simulations, and also during a simulation. In cases where this drive persists in spite of the development of magnetic stochasticity, which is favoured by moving the argon source in an ad hoc way from the plasma edge into the 2/1 island at some point in the simulation, a relaxation in the region

q
⩽
2

(roughly) takes place. This relaxation generates a plasma current spike comparable to the experimental one. Simulations are compared in detail to measurements via synthetic diagnostics, validating the model to some degree.
Large bulk photovoltaic effect and second-harmonic generation in few-layer pentagonal semiconductors PdS2 and PdSe2
Authors: Gudelli Vijay Kumar , Guo Guang-Yu 
Published: September 2021

Abstract
Recently, atomically thin PdSe2 semiconductors with rare pentagonal Se–Pd–Se monolayers were synthesized and were also found to possess superior properties such as ultrahigh air stability, tunable band gap and high carrier mobility, thus offering a new family of two-dimensional (2D) materials for exploration of 2D semiconductor physics and for applications in advanced opto-electronic and nonlinear photonic devices. In this work, we systematically study the nonlinear optical (NLO) responses [namely, bulk photovoltaic effect (BPVE), second-harmonic generation (SHG) and linear electric-optic (LEO) effect] of noncentrosymmetric bilayer (BL) and four-layer PdS2 and PdSe2 by applying the first-principles density functional theory with the generalized gradient approximation plus scissors-correction. First of all, we find that these few-layer PdX
2 (X = S and Se) exhibit prominent BPVE. In particular, the calculated shift current conductivity is in the order of 130 μA V−2, being very high compared to known BPVE materials. Similarly, their injection current susceptibilities are in the order of 100 × 108 A V−2 s−1, again being large. Secondly, the calculated SHG coefficients (χ
(2)) of these materials are also large, being one order higher than that of the best-known few-layer group 6B transition metal dichalcogenides. For example, the maximum magnitude of χ
(2) can reach 1.4 × 103 pm V−1 for BL PdSe2 at 1.9 eV and 1.2 × 103 pm V−1 at 3.1 eV for BL PdS2. Thirdly we find significant LEO coefficients for these structures in the low photon energy. All these indicate that 2D PdX
2 semiconductors will find promising NLO applications in light signal modulators, frequency converters, electro-optical switches and photovoltaic solar cells. Fourthly, we find that the large BPVE and SHG of the few-layer PdX
2 structures are due to strong intralayer directional covalent bonding and also 2D quantum confinement. Finally, we also discuss the prominent features of these NLO spectra of these materials in terms of their electronic structure and optical dielectric functions.