bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Trastuzumab Without Chemotherapy For Treating Early HER2-Positive Breast Cancer In Older Patients: A Cohort Study Accompanying With The RESPECT Trial
Authors: Sawaki Masataka , Taira Naruto , Uemura Yukari , Saito Tsuyoshi , Baba Shinichi , Kobayashi Kokoro , Kawashima Hiroaki , Tsuneizumi Michiko , Sagawa Noriko , Bando Hiroko , Takahashi Masato , Yamaguchi Miki , Takashima Tsutomu , Nakayama Takahiro , Kashiwaba Masahiro , Mizuno Toshiro , Yamamoto Yutaka , Iwata Hiroji , Toyama Tatsuya , Tsugawa Koichiro , Kawahara Takuya , Mukai Hirofumi 
Published: August 2021

Abstract
Purpose To gauge the effects of treatment practices on prognosis for all older patients with HER2-positive breast cancer, particularly to determine whether adjuvant trastuzumab alone can offer benefit over no adjuvant therapy. This report accompanies the RESPECT study, a randomized-controlled trial (RCT) comparing trastuzumab monotherapy with trastuzumab-plus-chemotherapy for early HER2-positive breast cancer.Patients and methods Patients who declined the RCT were treated based on the physician’s discretion. We studied the (1) trastuzumab-plus-chemotherapy group, (2) trastuzumab-monotherapy group, and (3) non-trastuzumab group (no therapy or anticancer therapy without trastuzumab). The primary endpoint was disease-free survival (DFS), which was compared using the propensity-score method.Results We enrolled 398 eligible patients, aged over 70 years, with HER2-positive invasive breast cancer, of whom 275 (69%) were in the RCT, and 123 (31%) were in this cohort group. The median age was 74.5 years. Among cohort group treatment categories were as follows: (1) trastuzumab-plus-chemotherapy group (n = 36, 30%), (2) trastuzumab-monotherapy group (n = 52, 43%), and (3) non-trastuzumab group (n = 32, 27%). A total of 73% of patients received trastuzumab-containing regimens, with or without chemotherapy. The 3-year DFS was 92.3% in the trastuzumab-plus-chemotherapy group, 89.2% in the trastuzumab-monotherapy group, and 82.5% in the non-trastuzumab group. DFS in the non-trastuzumab group was lower than in the trastuzumab-plus-chemotherapy and trastuzumab-monotherapy groups (propensity-adjusted HR: 3.29; 95% CI: 1.15–9.39; P = 0.026). The relapse-free survival in the non-trastuzumab group was lower than in the trastuzumab-plus-chemotherapy and trastuzumab monotherapy groups (propensity-adjusted HR = 7.80; 95% CI: 2.32–26.2, P < 0.0001). Chemotherapy with trastuzumab or trastuzumab monotherapy did not affect health-related quality of life (HRQoL) at 36 months.Conclusions Trastuzumab-treated patients had better prognoses than patients not treated with trastuzumab without deterioration of HRQoL. Thus, trastuzumab monotherapy can be considered for patients who reject chemotherapy.Trial registration number The protocol was registered on the website of the University Hospital Medical Information Network (UMIN), Japan (protocol ID: UMIN 000028476).
GIS-based Land Suitability Analysis for Surface Irrigation Using Analytical Hierarchy Process Method in East and West Bellessa, Northwestern Ethiopia
Authors: Wubalem Azemeraw 
Published: August 2021

Abstract
Bellessa is found in central Gondar, which is affected frequently by drought thanks to spatial and temporal failure of rainfall. Therefore, the agriculture in this area has to be supported by surface irrigation. For this, land suitability analysis for surface irrigation is extremely important to scale back food security problem. GIS-based land suitability analysis was conducted using analytical hierarchy process methods. Eight factors like slope, elevation, distance to water source, land use, soil texture, type, depth, and drainage are considered and therefore the weight of every parameter was estimated using 8x8 pairwise comparison matrix. After all, final land suitability map was generated using weighted overlay method under GIS tool. the ultimate map was classified into four land suitable classes using natural break classification method as highly suitable (S1), moderately suitable (S2), marginally suitable (S3), and not suitable class (S4). The result showed that highly suitable, moderately suitable, marginally suitable and not suitable class are covered 13.9%, 46.9%, 26.9%, and 12.2% of the whole area, respectively. This study finding will features a vital role in conducting surface irrigation considering the input parameters and therefore the final demarcated suitable land classes.
Experimental Study on the Reliability and the Precision-maintenance of the Ultra-precision Grinding Machine Based on the Key Subsystem Platforms
Authors: Lei Pengli , Wang Zhenzhong , Shi Chenchun , Peng Yunfeng , Lu Feng , Liu Zuhui 
Published: August 2021

Abstract
The development of high-reliability, high-precision large-scale CNC ultra-precision grinding machines is essential for the efficient processing and manufacturing of large-diameter optical components. In this paper, we studied the reliability and the precision-maintenance of the ultra-precision grinding machine tool experimentally. First, the subsystems with poor performance was identified based on former operating data, which turned out to be the hydrostatic spindle subsystem and the feed subsystem. Then, we set up specific experimental platforms for these two subsystems in order to study the thermal deformation and thermal characteristics. The temperature difference between the inflow and outflow oils of the hydrostatic systems is used as the key parameter to model the accuracy evolution. Our results may provide a method to reveal the relationship between the thermal characteristics and the operating parameters of the subsystems, an therefore compensate the thermal error of the whole ultra-precision grinding machine.
Determination of Seismic Role of Non-Structural Components On Earthquake Behaviour of RC Buildings Using Various Seismic Design Codes And Fault Distances
Authors: Karalar Memduh , Çavuşli Murat , Mert Necati 
Published: August 2021

Abstract
Performance-based building engineering requires the synchronization of performances between non-structural and structural components. However, non-structural components are not generally taken into account in structural modelling. In this study, it is aimed to examine the seismic damage effects of non-structural components (NCs) on earthquake performance of RC buildings. For this purpose, 5 multi-story RC building collapsed in a strong earthquake is modelled as three dimensional (3D) using SAP2000 software. Brick, bookcase, bedroom, armchair, washing machine, dish washer, refrigerator is selected as NC in 3D analyses. NCs are modelled as anchored and unanchored to RC building and these NCs are modelled in the RC building taking into account UBC 2018, IBC 2018, ASCE/SI 7-30 code, New Zealand code, and Eurocode 8 code. Considering these standards for anchored / non-anchored / non-NC situations, earthquake analyses are performed separately for far fault and near fault. According to 3D nonlinear seismic analyses, it is clearly seen that NCs strongly affect earthquake behaviour of RC buildings. Besides, it is strongly recommended that non-structural elements should not be ignored while modelling a RC building. Then, it is understood that anchoring or not anchoring non-structural elements to RC structures seriously changes nonlinear seismic behaviour of these structures.
COVID-19: An In-Silico Analysis on Potential Therapeutic Uses of Trikadu as Immune System Boosters
Authors: Khasamwala Rukaiya Hasani , S Ranjani , Hemalatha S 
Published: August 2021

Abstract
Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this World. With the vaccines still in the trials, Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system using herbal remedies. India is famous for traditional medicinal formulations which includes, ‘Trikadu’ –A combination of three acrids namely Zingiber officinale, Piper nigrum and Piper longum which has antioxidant properties that boost our immune system hence acting as a strong preventive measure. In this study AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA Dependant polymerase protein and Enveloped protein of the virus. Analysis of the results showed that Coumarin, Coumaperine and Bisdemethoxycurcumin showed strong bonding interactions with both the proteins. We can conclude that Trikadu are the potential molecules which can be incorporated in the diet to boost the immune system as a preventive measure against the virus.
Recommendations for Analgesia and Sedation in Critically ill Children Admitted to Intensive Care Unit
Authors: Amigoni Angela , Conti Giorgio , Conio Alessandra , Corno Manuela , Fazio Paola Claudia , Ferrero Federica , Gentili Marta , Giugni Cristina , L'Erario Manuela , Masola Maria Maristella , Moliterni Paola , Pagano Giuseppe , Ricci Zaccaria , Romagnoli Stefano , Vasile Beatrice , Vitale Francesca , Marinosci Geremia Zito , Mondardini Maria Cristina 
Published: August 2021

Abstract
We aim to develop evidence-based recommendations for intensivists caring for children admitted to intensive care units and requiring analgesia and sedation. A panel of national pediatric intensivists expert in the field of analgesia and sedation and other specialists (a pediatrician, a neuropsychiatrist, a psychologist, a neurologist, a pharmacologist, an anesthesiologist, two critical care nurses, a methodologist) started in 2018 a 2- years process. Three meetings and one electronic-based discussion were dedicated to the development of the recommendations (presentation of the project, selection of research questions, overview of text related to the research questions, discussion of recommendations). A telematic anonymous consultation was adopted to reach the final agreement on recommendations. A formal conflict-of-interest declaration was obtained from all the authors. Eight areas of direct interest and one additional topic were considered to identify the best available evidence and to develop the recommendations using the Evidence-to-Decision framework according to Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. For each recommendation, the level of evidence, the strength of the recommendation, the benefits, the harms and the risks, the benefit/harm balance, the intentional vagueness, the values judgment, the exclusions, the difference of the opinions, the knowledge gaps and the research opportunities were reported. The panel produced 17 recommendations. Nine were evaluated as strong, 3 as moderate, 5 as weak. Conclusion: a panel of national experts achieved consensus regarding recommendations for the best care in terms of analgesia and sedation in critically ill children.
Factors associated with sunbed use among 3692 outpatients in 18 centers of the Italian Cancer League (LILT)
Authors: Mastroeni Simona , Sampogna Francesca , Salcedo Nidia Melo , Ricci Francesco , Fania Luca , Antonelli Flaminia , Abeni Damiano , Cristofolini Mario 
Published: August 2021

Abstract
Indoor tanning is associated with an increased risk of skin cancer. Nonetheless, its use is still widespread. We aimed to investigate the socio-demographic and clinical characteristics of sunbeds users in a group of participants in the skin cancer prevention campaign organized by the Italian Cancer League (LILT). During almost two years, 4409 individuals were screened in 18 centers. Participants reported having used sunbeds before the age of 15 years in 2.2% of cases, while after the age of 15 years the prevalence of use was 22.2%. Participants with complete information were 3692. Sunbeds users aged > 15 years were significantly more frequently females, young, living in Northern Italy, highly educated, and ever smokers. They had darker phototype, more common nevi, had used sunbeds more frequently before the age of 15, reported a history of sunburns, and the use of sunscreens. Indoor tanning is an important public health issue and a relevant aspect of primary prevention. However, not all countries have adopted the recommendations by the World Health Organization (WHO) on health risks associated with artificial tanning. A deeper insight into the topic may contribute to identify the best prevention strategies.
Fisetin has Inhibitory Effects on the TLR 4/NF-κB-Mediated Inflammatory Pathway After Traumatic Brain Injury in Mice: A Potential Neuroprotective Role
Authors: Zhou Chenhui , Nie Sheng , Wang Zhepei , Gong Fanyong , Wu Jingmi , Huang Yi , Gao Xiang 
Published: August 2021

Abstract
Inflammatory response contributes to the high mortality and morbidity of traumatic brain injury (TBI). Potent anti-inflammatory effects can alleviate brain injury after TBI. Fisetin has anti-inflammatory properties in several brain injury models, but the effects of fisetin on inflammation after TBI is still unclear. Our study aimed to investigate the neuroprotective effects of fisetin against inflammation after TBI in mice.Fisetin (25 mg/kg, 50 mg/kg or 75 mg/kg) or equal volume of vehicle was given via intraperitoneal injection 30 min after TBI. The neurological severity score, brain edema and blood brain barrier (BBB) permeability were assayed after TBI. In further mechanistic studies, changes in the toll-like receptor 4 (TLR 4)/nuclear factor-κB (NF-κB) pathway and the expression of pro-inflammatory cytokines were measured. Fisetin significantly improved behavioral outcomes and reduced brain edema after TBI. These changes were associated with significant reductions in TLR 4 expression and NF-κB activity. In addition, changes in the expression of pro-inflammatory cytokines were detected 24 h after TBI. Our study provided the first evidence that fisetin exerted neuroprotective effects by inhibiting the TLR 4/NF-κB–mediated inflammatory pathway after TBI in mice.
The Production of Biodiesel From Plum Waste Oil Using Nano-Structured Catalyst Loaded Into Supports
Authors: Saeed Aasma , Hanif Muhammad Asif , Nawaz Haq , Qadri Rashid Waseem Khan 
Published: August 2021

Abstract
The present study was undertaken with aims to produced catalyst loaded on low-cost clay supports and to utilize plum waste seed oil for the production of biodiesel. For this purpose, Bentonite-potassium ferricyanide, White pocha-potassium ferricyanide, Granite-potassium ferricyanide, Sindh clay-potassium ferricyanide, and Kolten-potassium ferricyanide composites were prepared. The maximum biodiesel yield was recorded for Bentonite-potassium ferricyanide composite. This composite was subjected to calcination process to produce Calcinized bentonite -potassium ferricyanide composite and a further improvement in biodiesel amount was recorded. The fuel quality parameters of all biodiesel samples were found in the recorded range. Gas chromatographic mass spectrometric analysis confirmed the presence of oleic and linoleic acids in the plum seed oil. The characterization of composite was done using FTIR, SEM and EDX. Two infrared bands are observed in the spectrum from 1650-1630 cm-1 indicates that the composite materials contained highly hydrogen bonded water. The presence of surface hydroxyls groups can also be confirmed from FTIR data. SEM image clearly show the presence of nano-rods on the surface of Granite-potassium ferricyanide and Kolten-potassium ferricyanide composites. Another interesting observation that can be recorded from SEM images is the changes in surface characteristic of Bentonite-potassium ferricyanide composite after calcination. Calcinized bentonite-potassium ferricyanide composite found to contain more nano rod like structures at its surface as compared to Bentonite-potassium ferricyanide composite which contained spherical particles. EDX data of Bentonite-potassium ferricyanide composite and Calcinized bentonite-potassium ferricyanide composite show that after calcination carbon and oxygen was reduced. The other lost volatile compounds after calcination were of Na, Mg, Al, Si, and S.
Characteristics of Concentrated Lignocellulosic Nanofibrils Suspension
Authors: Wang Ping , Huang Luyao , He Lilong , Gao Wenhua , Zeng Jinsong , Wang Bin , Xu Jun , Wang Zhiwei 
Published: August 2021

Abstract
Lignocellulosic nanofibrils (LCNF) is usually isolated from biomass with concentration less than 2.0 wt%. The low concentration limited the transportation and end-use application of LCNF. Therefore, the development of concentration process and the characteristics of concentrated LCNF become desirable and important for commercial deployment of LCNF application. In this study, 1.0 wt% LCNF suspension was dewatered to solid concentration of 5.9 wt%, 16.3 wt% and 25.9 wt% by a centrifuge, respectively. The un-concentrated LCNF suspension showed obviously stable translucent and well dispersed in water, while the concentrated LCNF exhibited the gel-like behavior or “solid-like” behavior based on the concentration degree. The bundle-like fibrils were observed in the concentrated LCNF, and average diameter of concentrated LCNF became large but still less than 100 nm. The crystallinity and crystallite size of un-concentrated LCNF and concentrated LCNF were similar, and it was indicated that the morphological structure changes of LCNF mainly occurred in the amorphous region of fibrils. The concentrated LCNF films still had relatively good UV-blocking property, water absorption and oxygen permeability. The increasing basis weight of films was benefit for enhancing the surface smoothness of films and interweaves between fibrils, resulting in the tensile index and specific modulus of films increasing. In sum, the concentration process affected the morphology structure of LCNF, but the concentrated LCNF still kept relatively good properties. Concentration process of LCNF suspension may be a feasible strategy for large-scale LCNF production and storage.
Genetic Diversity and Differentiation of Alpinia Oxyphylla Miquel as Revealed by AFLP Markers
Authors: Pan Kun , Hou Jie , Su Wenqin , Yi Bo , Gao Bingmiao 
Published: August 2021

Abstract
In this study, we analyzed the genetic diversity and population structure of 90 A. oxyphylla accessions from Hainan island using amplified fragment length polymorphism (AFLP) markers. These 90 accessions were composed of 15 populations from different geographic locations and divided into 4 clusters (A, B, C, and D) using the Unweighted pair group method based on arithmetic average (UPGMA). The genetic similarity between individuals ranged from 0.47 to 1.00 (average of 0.74), and most accessions from the same geographic population were grouped together. Principal coordinate analysis (PCA) showed a clear distinction among three clusters (A, B and C). Based on the loci information, the population structure analysis results by STRUCTURE and TESS were consistent with the clustering of PCA. Nine AFLP primer combinations generated 1537 polymorphic bands displaying rich polymorphism, thus indicating high genetic diversity among these 15 populations with an average Nei’s gene diversity of 0.1328 ± 0.160. In conclusion, AFLP markers efficiently analyzed the genetic diversity in A. oxyphylla, demonstrating highly significant genetic variation within and among populations. However, intrapopulation genetic variance was much higher than interpopulation variability, suggesting that efforts should be made for in situ germplasm conservation and resistant varieties cultivation.
Identification of Four Serum miRNAs as Potential Markers to Screen for Thirteen Cancer Types
Authors: Chen Joe W. , Dhahbi Joseph 
Published: August 2021

Abstract
Introduction: Cancer has consistently remained one of the top causes of death in the United States every year, with many cancer deaths preventable if detected early. Circulating serum miRNAs pose as a promising, minimally invasive supplement, or even alternative, to many current screening procedures. Many studies have shown that different serum miRNAs can discriminate healthy individuals from those with certain types of cancer. Although many of those miRNAs are often reported to be significant in one cancer type, they are also altered in other types of cancers. Currently, very few studies have investigated serum miRNA biomarkers for multiple different cancer types simultaneously for general cancer screening.Method: To identify serum miRNAs that would be useful in simultaneously screening multiple types of cancers, microarray cancer datasets were curated, yielding 13 different types of cancer with a total of 3352 cancer samples and 2809 non-cancer samples. The samples were then divided into discovery and validation sets. A hundred random forest models were built using the discovery set to select candidate miRNAs. The selected miRNAs were then used in the validation set to see how well they can differentiate cancer from normal samples in an independent dataset. Further analysis of the interactions between these miRNAs and their target mRNAs were investigated as well.Result: The random forest models achieved an average of 97% accuracy in the discovery set with 95% bootstrap confidence interval from 0.9544 to 0.9778. The selected miRNAs were hsa-miR-663a, hsa-miR-6802-5p, hsa-miR-6784-5p, hsa-miR-3184-5p, and hsa-miR-8073. Each individual miRNA exhibited high area under the curve (AUC) value using receiver operating characteristic analysis. Moreover, the combination of four out of the five miRNAs achieved the highest AUC value of 0.9815 with perfect sensitivity, indicating that these miRNAs have a high potential for cancer screening. miRNA-mRNA interaction and protein-protein interaction analysis provided insights into how these miRNAs may play a role in cancer in general.
Comparative Study of Functional Outcomes between OTA/AO type C, Gustilo type I/II Open Fractures and Closed Fractures of the Distal Humerus Treated by Open Reduction and Internal Fixation.
Authors: chen Chen , Xiao Dan , Li Ting , Gong Maoqi , Zha Yejun , Hua Kehan , Sun Weitong , Ji Shangwei , Jiang Xieyuan 
Published: August 2021

Abstract
Background: To evaluate the difference of functional outcomes between OTA/AO type C, Gustilo type I/II open fractures and closed fractures of the distal humerus after open reduction and internal fixation.Methods: We retrospectively analyzed the clinical data of patients with OTA/AO-C distal humerus fractures who were treated in our department from January 2014 to December 2016. The patients were divided into an open fracture group and a closed fracture group. Their baseline characteristics and functional outcomes were analyzed and comparedResults: A total of 64 patients treated by operative fixation were identified (25 open and 39 closed injuries), and the average follow-up time was 35.1±13.6 months. There were no significant differences in the hospitalization time, operation time, intraoperative blood loss, medical costs, range of motion (ROM) of the elbow, Mayo Elbow Performance Score (MEPS), Disabilities of the Arm, Shoulder and Hand (DASH) score, or complications between the two groups (P>0.05).Conclusion: OTA/AO type C, Gustilo I/II distal humeral open fractures can yield satisfactory clinical results similar to those of closed distal humeral fractures after open reduction and internal fixation.Level of Evidence: Therapeutic Level III; Retrospective Cohort Comparison; Treatment Study.