bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metode Exponential Smoothing Pada Peramalan Tingkat Kriminalitas Pencurian Sepeda Motor
Authors: Novianti Novianti , Amin Muhammad , Kifti Wan Mariatul 
Published: April 2021

Abstract : This study aims to determine thecrime rate in motorbike theft cases using the programmeing langiage PHP and MySQL as a database and the application of the Exponential Smoothing method to determine the crime rate of motorcycle theft that occurs in the city of Tanjung Balai for the next period. The data used in this study is motorcycle theft report data from 2018 to 2019 wich was obtained from the Tanjung Balai Police. The benefits of this research can be used by the Tanjung Balai police to determine the extent of the motorcycle theft crime that will occur in a shorter, easier and more accurate manner so that it can take optimal prevention. With the Exponential Smoothing method the alpha value will be searched randomly to find an alpha value that was a minimum error value calculated using Means Absolute Percetage Error (MAPE). Then the prediction results that have an alphan with a minimum error are the best of recommended as a prediction result for the next period. Based on this research, the prediction results obtained from the prediction of the number of motorcycle theft cases the occurred in the city of Tanjung Balai in 2020 were 12 units with an MAPE error value of 0,153%. Keyword : Exponential Smoothing, Theft, Motorcycle, Forecasting Abstrak : Penelitian ini bertujuan untuk menentukan tingkat kriminalitas kasus pencurian sepeda motor dengan menggunakan bahasa pemrograman PHP dan MySQL sebagai basis data serta penerapan metode Exponential Smoothing untuk menentukan tingkat kriminalitas pencurian sepeda motor yang terjadi di kota Tanjung Balai untuk periode berikutnya. Data yang digunakan dalam penelitian ini adalah data laporan pencurian sepeda motor dari tahun 2018 sampai dengan tahun 2019 yang diperoleh dari POLRES Tanjung Balai. Manfaat dari penelitian ini dapat digunakan oleh kepolisian Tanjung Balai untuk menentukan seberapa besar tindak kriminalitas pencurian sepeda motor yang akan terjadi secara lebih singkat, mudah dan akurat sehingga dapat melakukan pencegahan yang optimal. Dengan metode Exponential Smoothing akan dicari nilai alpha secara acak sampai menemukan nilai alpha yang memiliki nilai error yang minimum yang dihitung menggunakan Means Absolute Percetage Error (MAPE). Maka hasil prediksi yang memiliki alpha dengan error minimumlah yang paling baik atau direkomendasikan sebagai hasil prediksi untuk periode selanjutnya. Berdasarkan penelitian ini diperoleh hasil prediksi peramalan jumlah kasus pencurian sepeda motor yang terjadi di kota Tanjung Balai tahun 2020 adalah 12 unit dengan nilai error MAPE sebesar 0,153%. Kata Kunci : Exponential Smoothing, Pencurian, Sepeda Motor, Forecasting
Metode Customer Relationship Management untuk Stokis Luxor Cabang Kisaran Berbasis Web
Authors: Panjaitan Cici Paramita , Siregar Iqbal Kamil , Santoso Santoso 
Published: April 2021

Abstract : Customer relationship management is a facility to strengthen relationship between companies and customers. CRM also establishes sales programs to build and manage close ties with customers so as not to move to other competitors. This thesis presents an increase in web-based CRM in Stockist Luxor Kisaran. Luxor Stockist is a business entity engaged in marketing herbal products, the system used is still with a manual system. The results of the fundamental method on the web obtained are managing customer data, product improvement, product sales, and consumer consultation facilities to respond to questions and suggestions from customers. This application uses the PHP and MYSQL programming language for the media to make it easier for customers to interact with the company. This application is expected to help companies strengthen the good word with customers in retaining customers and to get new customers. Keyword :Customer Relationship Management, Marketing, Services, PHP language and MYSQL database Abstrak : Manajemen hubungan pada pelanggan ialah suatu fasilitas guna mempererat jalinan baik perusahaan dan pelanggan. CRM juga membentuk program penjualan guna membangun serta mengatur ikatan yang erat pada pelanggan agar tidak berpindah ke pesaing lain. Skripsi ini menyajikan peningkatan CRM berbasis web di Stokis Luxor Kisaran. Stokis Luxor merupakan badan usaha yang bergerak dalan pemasaran produk herbal, sistem yang digunakan masih dengan sistem manual. Hasil metode mendasar pada web yang didapat adalah mengatur data konsumen, peningkatan produk, penjualan produk, dan fasilitas konsultasi konsumen guna menanggapi pertanyaan maupun saran dari pelanggan. Aplikasi ini memakai bahasa program PHP dan MYSQL untuk media agar memudahkan pelanggan untuk berinteraksi dengan perusahaan.. Aplikasi ini diharap dapat membantu perusahaan dalam mempererat ikataan baik dengan pelanggan dalam mempertahankan pelanggan dan untuk mendapatkan pelanggan baru.Kata Kunci:Customer Relationship Management,Pemasaran ,Pelayanan, bahasa PHP dan database MYSQL
Abnormal Expression of YAP Is Associated With Proliferation, Differentiation, Neutrophil Infiltration, and Adverse Outcome in Patients With Nasal Inverted Papilloma
Authors: Yuan Tian , Zheng Rui , Zhou Xiang-min , Jin Peng , Huang Zhi-qun , Zi Xiao-xue , Wu Qing-wu , Wang Wei-hao , Deng Hui-yi , Kong Wei-feng , Qiu Hui-jun , Zhou Sui-zi , Chen Qian-min , Tu Yan-yi , Li Tao , Liu Jing , Tan Kai Sen , Ong Hsiao Hui , Shi Li , Chen Zhuang-gui , Huang Xue-kun , Yang Qin-tai , Wang De-yun 
Published: April 2021

BackgroundNasal inverted papilloma (NIP) is a common benign tumor. Yes-associated protein (YAP) is the core effector molecule of the Hippo pathway, which regulates the proliferation and differentiation of airway epithelium. While its role in proliferation may be connected to NIP formation, no definitive association has been made between them.MethodsWe compared the difference of YAP expression and proliferation level between the control inferior turbinate, NP (nasal polyps), and NIP groups. In addition, we further used PCR, immunofluorescence, and immunohistochemistry to investigate YAP’s role in the proliferation and differentiation of the nasal epithelium and inflammatory cell infiltration, correlating them with different grades of epithelial remodeling. We further used an IL-13 remodeling condition to investigate YAP’s role in differentiation in an in vitro air-liquid interface (ALI) human nasal epithelial cell (hNECs) model. Finally, we also explored the correlation between YAP expression and clinical indicators of NIP.ResultsThe expression of YAP/active YAP in the NIP group was significantly higher than that in the NP group and control group. Moreover, within the NIP group, the higher grade of epithelial remodeling was associated with higher YAP induced proliferation, leading to reduced ciliated cells and goblet cells. The finding was further verified using an IL-13 remodeling condition in differentiating ALI hNECs. Furthermore, YAP expression was positively correlated with proliferation and neutrophil infiltration in NIP. YAP expression was also significantly increased in NIP patients with adverse outcomes.ConclusionAbnormal expression of YAP/active YAP is associated with proliferation, differentiation, neutrophil infiltration, and adverse outcome in NIP and may present a novel target for diagnosis and intervention in NIP.
Formaldehyde Molecules Adsorption on Zn Doped Monolayer MoS2: A First-Principles Calculation
Authors: Li Huili , Fu Ling , He Chaozheng , Huo Jinrong , Yang Houyong , Xie Tingyue , Zhao Guozheng , Dong Guohui 
Published: April 2021

Based on the first principles of density functional theory, the adsorption behavior of H2CO on original monolayer MoS2 and Zn doped monolayer MoS2 was studied. The results show that the adsorption of H2CO on the original monolayer MoS2 is very weak, and the electronic structure of the substrate changes little after adsorption. A new kind of surface single cluster catalyst was formed after Zn doped monolayer MoS2, where the ZnMo3 small clusters made the surface have high selectivity. The adsorption behavior of H2CO on Zn doped monolayer MoS2 can be divided into two situations. When the H-end of H2CO molecule in the adsorption structure is downward, the adsorption energy is only 0.11 and 0.15 eV and the electronic structure of adsorbed substrate changes smaller. When the O-end of H2CO molecule is downward, the interaction between H2CO and the doped MoS2 is strong leading to the chemical adsorption with the adsorption energy of 0.80 and 0.98 eV. For the O-end-down structure, the adsorption obviously introduces new impurity states into the band gap or results in the redistribution of the original impurity states. All of these may lead to the change of the chemical properties of the doped MoS2 monolayer, which can be used to detect the adsorbed H2CO molecules. The results show that the introduction of appropriate dopant may be a feasible method to improve the performance of MoS2 gas sensor.
Establishing a Risk Prediction Model for Atherosclerosis in Systemic Lupus Erythematosus
Authors: Xing Haiping , Pang Haiyu , Du Tian , Yang Xufei , Zhang Jing , Li Mengtao , Zhang Shuyang 
Published: April 2021

Background and aims: Patients with systemic lupus erythematosus (SLE) have a significantly higher incidence of atherosclerosis than the general population. Studies on atherosclerosis prediction models specific for SLE patients are very limited. This study aimed to build a risk prediction model for atherosclerosis in SLE.Methods: RNA sequencing was performed on 67 SLE patients. Subsequently, differential expression analysis was carried out on 19 pairs of age-matched SLE patients with (AT group) or without (Non-AT group) atherosclerosis using peripheral venous blood. We used logistic least absolute shrinkage and selection operator regression to select variables among differentially expressed (DE) genes and clinical features and utilized backward stepwise logistic regression to build an atherosclerosis risk prediction model with all 67 patients. The performance of the prediction model was evaluated by area under the curve (AUC), calibration curve, and decision curve analyses.Results: The 67 patients had a median age of 42.7 (Q1–Q3: 36.6–51.2) years, and 20 (29.9%) had atherosclerosis. A total of 106 DE genes were identified between the age-matched AT and Non-AT groups. Pathway analyses revealed that the AT group had upregulated atherosclerosis signaling, oxidative phosphorylation, and interleukin (IL)-17-related pathways but downregulated T cell and B cell receptor signaling. Keratin 10, age, and hyperlipidemia were selected as variables for the risk prediction model. The AUC and Hosmer–Lemeshow test p-value of the model were 0.922 and 0.666, respectively, suggesting a relatively high discrimination and calibration performance. The prediction model had a higher net benefit in the decision curve analysis than that when predicting with age or hyperlipidemia only.Conclusions: We built an atherosclerotic risk prediction model with one gene and two clinical factors. This model may greatly assist clinicians to identify SLE patients with atherosclerosis, especially asymptomatic atherosclerosis.
Novel Biomarkers of Dynamic Blood PD-L1 Expression for Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer Patients
Authors: Yang Qiao , Chen Mingjing , Gu Jiaoyang , Niu Kai , Zhao Xianlan , Zheng Linpeng , Xu Zihan , Yu Yongxin , Li Feng , Meng Lingxin , Chen Zhengtang , Zhuo Wenlei , Zhang Luping , Sun Jianguo 
Published: April 2021

BackgroundImmune checkpoint inhibitors (ICIs) have become a high-profile regimen for malignancy recently. However, only a small subpopulation obtains long-term clinical benefit. How to select optimal patients by reasonable biomarkers remains a hot topic.MethodsPaired tissue samples and blood samples from 51 patients with advanced malignancies were collected for correlation analysis. Dynamic changes in blood PD-L1 (bPD-L1) expression, including PD-L1 mRNA, exosomal PD-L1 (exoPD-L1) protein and soluble PD-L1 (sPD-L1), were detected after 2 months of ICIs treatment in advanced non-small-cell lung cancer (NSCLC) patients. The best cutoff values for progression-free survival (PFS) and overall survival (OS) of all three biomarkers were calculated with R software.ResultsIn 51 cases of various malignancies, those with positive tissue PD-L1 (tPD-L1) had significantly higher PD-L1 mRNA than those with negative tPD-L1. In 40 advanced NSCLC patients, those with a fold change of PD-L1 mRNA ≥ 2.04 had better PFS, OS and best objective response (bOR) rate. In addition, a fold change of exoPD-L1 ≥ 1.86 was also found to be associated with better efficacy and OS in a cohort of 21 advanced NSCLC cases. The dynamic change of sPD-L1 was not associated with efficacy and OS. Furthermore, the combination of PD-L1 mRNA and exoPD-L1 could screen better patients for potential benefit from ICIs treatment.ConclusionThere was a positive correlation between bPD-L1 and tPD-L1 expression. Increased expression of PD-L1 mRNA, exoPD-L1, or both in early stage of ICIs treatment could serve as positive biomarkers of efficacy and OS in advanced NSCLC patients.
Nanostructured β‐tricalcium Phosphate (Ca3(PO4)2 Based Electrochemical Sensor for Detection of Methyl Parathion and Mercury (II) Ions
Authors: Sudhan Narayanan , Sekar Chinnathambi 
Published: April 2021

In this work, we have fabricated a new electrochemical sensor based on β‐tricalcium phosphate (Ca3(PO4)2) nanoparticles (NPs) modified glassy carbon electrode (GCE) for the selective nonenzymatic determination of methyl parathion and mercury (II) ions independently. β‐tricalcium phosphate (β‐TCP) NPs were prepared by chemical precipitation method and structural and morphological properties were investigated by XRD, FTIR, and SEM. The electrochemical behavior of MP and mercury (Hg2+) ions were investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques using β‐TCP/GCE. The modified electrode exhibited excellent electrocatalytic activity towards both the MP and Hg over a wide linear range from 0.15 to 141 μM and 1–381 µM with the lowest detection limits of 88 and 136.4 nM respectively. The sensor has high selectivity towards MP and Hg in the presence of major interfering compounds such as 3-nitrophenol, 4-nitrophenol, 4-aminophenol, catechol, hydroquinone and heavy metals such as lead, cadmium and arsenic. Applicability of the fabricated sensor for detection of MP and Hg (II) ions has been tested in tap water by standard addition method.
An Epigenetically Distinct Subset of Children With Autism Spectrum Disorder Resulting From Differences in Blood Cell Composition
Authors: Jangjoo Maryam , Goodman Sarah J. , Choufani Sanaa , Trost Brett , Scherer Stephen W. , Kelley Elizabeth , Ayub Muhammad , Nicolson Rob , Georgiades Stelios , Crosbie Jennifer , Schachar Russell , Anagnostou Evdokia , Grunebaum Eyal , Weksberg Rosanna 
Published: April 2021

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that often involves impaired cognition, communication difficulties and restrictive, repetitive behaviors. ASD is extremely heterogeneous both clinically and etiologically, which represents one of the greatest challenges in studying the molecular underpinnings of ASD. While hundreds of ASD-associated genes have been identified that confer varying degrees of risk, no single gene variant accounts for &gt;1% of ASD cases. Notably, a large number of ASD-risk genes function as epigenetic regulators, indicating potential epigenetic dysregulation in ASD. As such, we compared genome-wide DNA methylation (DNAm) in the blood of children with ASD (n = 265) to samples from age- and sex-matched, neurotypical controls (n = 122) using the Illumina Infinium HumanMethylation450 arrays.Results: While DNAm patterns did not distinctly separate ASD cases from controls, our analysis identified an epigenetically unique subset of ASD cases (n = 32); these individuals exhibited significant differential methylation from both controls than the remaining ASD cases. The CpG sites at which this subset was differentially methylated mapped to known ASD risk genes that encode proteins of the nervous and immune systems. Moreover, the observed DNAm differences were attributable to altered blood cell composition, i.e., lower granulocyte proportion and granulocyte-to-lymphocyte ratio in the ASD subset, as compared to the remaining ASD cases and controls. This ASD subset did not differ from the rest of the ASD cases in the frequency or type of high-risk genomic variants.Conclusion: Within our ASD cohort, we identified a subset of individuals that exhibit differential methylation from both controls and the remaining ASD group tightly associated with shifts in immune cell type proportions. This is an important feature that should be assessed in all epigenetic studies of blood cells in ASD. This finding also builds on past reports of changes in the immune systems of children with ASD, supporting the potential role of altered immunological mechanisms in the complex pathophysiology of ASD. The discovery of significant molecular and immunological features in subgroups of individuals with ASD may allow clinicians to better stratify patients, facilitating personalized interventions and improved outcomes.
Does Cathodal vs. Sham Transcranial Direct Current Stimulation Over Contralesional Motor Cortex Enhance Upper Limb Motor Recovery Post-stroke? A Systematic Review and Meta-analysis
Authors: Chen Joyce L. , Schipani Ashley , Schuch Clarissa Pedrini , Lam Henry , Swardfager Walter , Thiel Alexander , Edwards Jodi D. 
Published: April 2021

Background: During recovery from stroke, the contralesional motor cortex (M1) may undergo maladaptive changes that contribute to impaired interhemispheric inhibition (IHI). Transcranial direct current stimulation (tDCS) with the cathode over contralesional M1 may inhibit this maladaptive plasticity, normalize IHI, and enhance motor recovery.Objective: The objective of this systematic review and meta-analysis was to evaluate available evidence to determine whether cathodal tDCS on contralesional M1 enhances motor re-learning or recovery post-stroke more than sham tDCS.Methods: We searched OVID Medline, Embase, and the Cochrane Central Register of Controlled Trials for participants with stroke (&gt;1 week post-onset) with motor impairment and who received cathodal or sham tDCS to contralesional M1 for one or more sessions. The outcomes included a change in any clinically validated assessment of physical function, activity, or participation, or a change in a movement performance variable (e.g., time, accuracy). A meta-analysis was performed by pooling five randomized controlled trials (RCTs) and comparing the change in Fugl–Meyer upper extremity scores between cathodal and sham tDCS groups.Results: Eleven studies met the inclusion criteria. Qualitatively, four out of five cross-over design studies and three out of six RCTs reported a significant effect of cathodal vs. sham tDCS. In the quantitative synthesis, cathodal tDCS (n = 65) did not significantly reduce motor impairment compared to sham tDCS (n = 67; standardized mean difference = 0.33, z = 1.79, p = 0.07) with a little observed heterogeneity (I2 = 5%).Conclusions: The effects of cathodal tDCS to contralesional M1 on motor recovery are small and consistent. There may be sub-populations that may respond to this approach; however, further research with larger cohorts is required.
Relationship Between Glycosylated Hemoglobin and Short-Term Mortality of Spontaneous Intracerebral Hemorrhage
Authors: Lu Ping , Cui Lingyun , Wang Yu , Kang Kaijiang , Gu Hongqiu , Li Zixiao , Liu Liping , Wang Yilong , Zhao Xingquan 
Published: April 2021

Background: The relationship between glycosylated hemoglobin (HbA1c) and prognosis of spontaneous intracerebral hemorrhage (SICH) patients has not been fully elucidated. This study aimed to reveal the relationship between HbA1c levels and short-term mortality after patient admission with SICH.Methods: It was a large-scale, multicenter, cross-sectional study. From August 1, 2015, to July 31, 2019, a total of 41910 SICH patients were included in the study from the Chinese Stroke Center Alliance (CSCA) program. Finally, we comprehensively analyzed the data from 21,116 patients with SICH. HbA1c was categorized into four groups by quartile. Univariate and multivariate logistic regression analyses were used to assess the association between HbA1c levels and short-term mortality in SICH patients.Results: The average age of the 21,116 patients was 62.8 ± 13.2 years; 13,052 (61.8%) of them were male, and 507 (2.4%) of them died. Compared to the higher three quartiles of HbA1c, the lowest quartile (≤5.10%) had higher short-term mortality. In subgroup analysis with or without diabetes mellitus (DM) patients, the mortality of the Q3 group at 5.60–6.10% was significantly lower than that of the Q1 group at ≤5.10%. After adjustment for potential influencing factors, the ROC curve of HbA1c can better predict the short-term mortality of patients with SICH (AUC = 0.6286 P &lt; 0.001).Conclusions: Therefore, we concluded that low or extremely low HbA1c levels (≤5.10%) after stroke were associated with higher short-term mortality in SICH patients, with or without DM.
Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia
Authors: Xu Qiang , Weng Yifei , Liu Chang , Qiu Lianli , Yang Yulin , Zhou Yifei , Wang Fangyu , Lu Guangming , Zhang Long Jiang , Qi Rongfeng 
Published: April 2021

Purpose: We aimed to find out the distributed functional connectome of white matter in patients with functional dyspepsia (FD).Methods: 20 patients with FD and 24 age- and gender-matched healthy controls were included into the study. The functional connectome of white matter and graph theory were used to these participants. Two-sample t-test was used for the detection the abnormal graph properties in FD. Pearson correlation was used for the relationship between properties and the clinical and neuropshychological information.Results: Patients with FD and healthy controls showed small-world properties in functional connectome of white matter. Compared with healthy controls, the FD group showed decreased global properties (Cp, S, Eglobal, and Elocal). Four pairs of fiber bundles that are connected to the frontal lobe, insula, and thalamus were affected in the FD group. Duration and Pittsburgh Sleep Quality Index positively correlated with the betweenness centrality of white matter regions of interest.Conclusion: FD patients turned to a non-optimized functional organization of WM brain network. Frontal lobe, insula, and thalamus were key regions in brain information exchange of FD. It provided some novel imaging evidences for the mechanism of FD.