bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Mucosectomy: A Novel Technique for Management of Polypoidal Solitary Rectal Ulcer Syndrome
Authors: Jha Ashish Kumar , Purkayastha Subham , Dayal Vishwa Mohan 
Published: May 2021

ABSTRACT
Solitary rectal ulcer syndrome (SRUS) is an uncommon disorder often challenging to treat. Surgical treatment is associated with suboptimal outcomes and postoperative complications. Argon plasma coagulation helps control rectal bleeding and healing of ulcers, but more extended follow-up data are not available. The macroscopic appearance of SRUS can be polypoid in 17%–25% of cases. Here, we describe a novel endoscopic technique for treating symptomatic patients with polypoidal variant of SRUS after failed medical and endoscopic argon plasma coagulation treatments.
Schistosoma japonicum Associated With Colorectal Cancer
Authors: Almoghrabi Anas , Mzaik Obaie , Attar Bashar 
Published: May 2021

ABSTRACT
Colorectal cancer (CRC) is one of the most common cancers worldwide, with increasing prevalence in Asian countries with a crude incidence of 21.1 per 100,000. Schistosoma is a genus of trematodes that infect millions of humans, affecting multiple organs, notably the intestines, liver, and bladder. Those trematodes may cause chronic inflammation in the affected organ leading to long-term complications such as fibrosis and neoplasia. There is rising evidence that infection with Schistosoma japonicum is correlated with the liver and CRC in endemic Asian countries. It is reported that chronic infection with Schistosomiasis raises the risk of CRC by 3 times. Less commonly seen outside of endemic areas, we present a case of S. japonicum-associated CRC in the United States in a woman with sigmoid adenocarcinoma and Schistosoma japonicum infection.
Microbiome Responses to Vancomycin Treatment in a Child With Primary Sclerosing Cholangitis and Ulcerative Colitis
Authors: Britto Savini Lanka , Hoffman Kristi Louise , Tessier Mary Elizabeth , Petrosino Joseph , Miloh Tamir , Kellermayer Richard 
Published: May 2021

ABSTRACT
The therapeutic effects of off-label oral vancomycin in pediatric and adult primary sclerosing cholangitis (PSC)-inflammatory bowel disease, more commonly PSC-ulcerative colitis (UC), indicate the translational relevance of disease-associated microbiome findings. This is the first report on longitudinal salivary and fecal microbiome changes in a pediatric PSC-UC patient over the first 90 days of vancomycin therapy. Increase in bacterial diversity and abundance changes in Fusobacterium, Haemophilus, and Neisseria were observed. Our findings highlight the importance of longitudinal microbiome sampling in PSC-UC and serve as a nidus for larger-scale observations toward advancing microbial therapeutics for PSC.
Geleit, Geleitsrecht und Juden im Mittelalter
Authors: Wenninger Markus J. 
Published: May 2021

Abstract
Safe conduct functioned in the Middle Ages and in the Early Modern period to provide a particular safety to travelers with proper protection on the one hand; on the other, it was practiced as an authoritative tool for the establishment of income and the control over travelers. Since the 13th century, a development of particular safe-conduct evolved, to which also tax-like dues were inherent. From its beginning, Jews, too, were integrated into this system – both as those receiving safe conduct and, especially in the 14th century, also investors, who leased tax revenues from local lords. Receiving safe-conduct was imperative to Jews in the later periods of the Middle Ages and the Early Modern age because of their mobility for trade and moneylending businesses. From the 14th century on, the social position of the Jews in Germany significantly worsened, and they were increasingly expelled from many cities and territories. Hence, Jews were only allowed to enter specific cities if they paid for the specific safe conduct. Contrary to earlier times, this did not include protection anymore, but merely the permission to enter the city. This essay describes this development by examining several case studies from the 13th to the early 16th centuries. One focus rests on the reign of Emperor Maximilian I, from which stem several revealing cases. From the safe conduct, which was granted to Jews, the term »Judengeleit« (safe-conduct for Jews, often simply called »safe-conduct/Geleit«) was developed in the 14th century, determining the acceptance and the right of abode for Jews in the cities and territories, which were common especially in the western regions of Germany. This phenomenon is discussed in this essay only concerning its formation and not regarding its further development.
The Effects of Oral Liposomal Glutathione and In Vitro Everolimus in Altering the Immune Responses against Mycobacterium bovis BCG Strain in Individuals with Type 2 Diabetes
Authors: To Kimberly , Cao Ruoqiong , Yegiazaryan Aram , Owens James , Sasaninia Kayvan , Vaughn Charles , Singh Mohkam , Truong Edward , Sathananthan Airani , Venketaraman Vishwanath 
Published: May 2021

Abstract
Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) still remains a devastating infectious disease in the world. There has been a daunting increase in the incidence of Type 2 Diabetes Mellitus (T2DM) worldwide. T2DM patients are three times more vulnerable to M. tb infection compared to healthy individuals. TB-T2DM coincidence is a challenge for global health control. Despite some progress in the research, M. tb still has unexplored characteristics in successfully evading host defenses. The lengthy duration of treatment, the emergence of multi-drug-resistant strains and extensive-drug-resistant strains of M. tb have made TB treatment very challenging. Previously, we have tested the antimycobacterial effects of everolimus within in vitro granulomas generated from immune cells derived from peripheral blood of healthy subjects. However, the effectiveness of everolimus treatment against mycobacterial infection in individuals with T2DM is unknown. Furthermore, the effectiveness of the combination of in vivo glutathione (GSH) supplementation in individuals with T2DM along with in vitro treatment of isolated immune cells with everolimus against mycobacterial infection has never been tested. Therefore, we postulated that liposomal glutathione (L-GSH) and everolimus would offer great hope for developing adjunctive therapy for mycobacterial infection. L-GSH or placebo was administered to T2DM individuals orally for three months. Study subjects’ blood was drawn pre- and post-L-GSH/or placebo supplementation, where Peripheral Blood Mononuclear Cells (PBMCs) were isolated from whole blood to conduct in vitro studies with everolimus. We found that in vitro treatment with everolimus, an mTOR (membrane target of rapamycin) inhibitor, significantly reduced intracellular M. bovis BCG infection alone and in conjunction with L-GSH supplementation. Furthermore, we found L-GSH supplementation coupled with in vitro everolimus treatment produced a greater effect in inhibiting the growth of intracellular Mycobacterium bovis BCG, than with the everolimus treatment alone. We also demonstrated the functions of L-GSH along with in vitro everolimus treatment in modulating the levels of cytokines such as IFN-γ, TNF-α, and IL-2 and IL-6, in favor of improving control of the mycobacterial infection. In summary, in vitro everolimus-treatment alone and in combination with oral L-GSH supplementation for three months in individuals with T2DM, was able to increase the levels of T-helper type 1 (Th1) cytokines IFN-γ, TNF-α, and IL-2 as well as enhance the abilities of granulomas from individuals with T2DM to improve control of a mycobacterial infection.
Investigations of the intrinsic corrosion and hydrogen susceptibility of metals and alloys using density functional theory
Authors: Taylor Christopher D. , Ke Huibin 
Published: May 2021

Abstract
Mechanisms for materials degradation are usually inferred from electrochemical measurements and characterization performed before, during, and after exposure testing and/or failure analysis of service materials. Predicting corrosion and other materials degradation modes, such as hydrogen-assisted cracking, from first-principles has generally been limited to thermodynamic predictions from Pourbaix or Ellingham diagrams and the Galvanic series. Using electronic structure calculations, modern first-principles methods can predict ab initio the key rate-controlling processes for corrosion and hydrogen susceptibility as a function of pH, potential, and solution chemistry, and materials composition and microstructure. Herein we review density functional theory (DFT) approaches for studying the electrochemical reactions occurring on fresh metal and alloy surfaces related to environmentally assisted cracking and localized corrosion/pitting. Predicted changes in surface chemistry as a function of the environment were correlated against experimental crack growth rate data obtained for alloys 718, 725, and pipeline steel under electrochemical control. We also review the application of the method to study the effects of alloying on the chloride susceptibility of stainless steels and Ni–Cr-based corrosion-resistant alloys. Perspectives for improving the model are given, and extending it to future fields of application in corrosion science and engineering.
Modular symbols for Teichmüller curves
Authors: McMullen Curtis T. 
Published: May 2021

AbstractThis paper introduces a space of nonabelian modular symbols𝒮⁢(V){{\mathcal{S}}(V)}attached to any hyperbolic Riemann surfaceV, and applies it to obtain new results on polygonal billiards and holomorphic 1-forms. In particular, it shows the scarring behavior of periodic trajectories for billiards in a regular polygon is governed by a countable set of measures homeomorphic toωω+1{\omega^{\omega}+1}.
Pragmatic failures in public-sign translation: an eco-pragma-translatology analysis of environmental signage in Quanzhou
Authors: Wang Caiying , Hou Guojin 
Published: May 2021

Abstract
This study proposes an integrated model called the Eco-Pragma-Translatology Model (EPTM) with four Kernel Guidelines for accounting for translation of public (environmental protection) signs. An EPTM analysis of pragmatic failures in public environmental protection signs (from the database) demonstrates that the ubiquitous errors and mistakes of rendering come under the rubric of pragmalinguistic failures of translation, sociopragmatic failures, or pragmatic failures straddling boundaries and leads to the conclusion that translators should correspondingly enhance their pragmalinguistic and/or sociopragmatic competence. EPTM is a new, interdisciplinary theoretical approach that largely applies to issues of poor translation of public signs.
Study on the synthesis and application of BaTiO3 nanospheres
Authors: On Do Viet , Vuong Le Dai , Chuong Truong Van , Quang Dao Anh , Tung Vo Thanh 
Published: May 2021

Abstract
In the present study, BaTiO3 nanospheres with a uniform particle size of around 100 nm were prepared by a hydrothermal route using Ba(OH)2.8H2O and TiO2 nanoparticles. Experimental results revealed that the main influencing factors for the formation of BaTiO3 nanospheres were molar Ba/Ti ratio (R
Ba/Ti), hydrothermal temperature, and time. Highly-dispersed BaTiO3 nanospheres (100 nm) were obtained under the optimum hydrothermal conditions at temperature = 200°C, time = 12 h, and R
Ba/Ti = 1.5. Under these optimum conditions, BaTiO3 ceramics were synthesized from the as-prepared BaTiO3 nanospheres, and their structural, microstructural, and electrical properties were investigated. The BaTiO3 ceramics exhibited a high dielectric constant of 7300 at a Curie temperature of 125 °C, great density (ρ), 5.83 g cm–3; large dielectric constant at room temperature er = 3586 and tan d = 0.03, high remanant polarization P
r = 10.6 μC cm–2, low coercive field E
c = 4.5 kVcm–1.
Influence of Clerodendrum volubile leaf extract on doxorubicin-induced toxicity and inhibition of carbonyl reductase mediated metabolism
Authors: Molehin Olorunfemi R. , Idowu Kehinde A. , Olaoye Ayonposi B. , Fakayode Aderonke E. , Adesua Oluwatumininu O. 
Published: May 2021

Abstract

Objectives
Doxorubicin (DOX) is a commonly used chemotherapeutic drug. However, its non-target organ toxicities pose a serious problem. This study is to assess the protective role of Clerodendrum volubile leaf extract (CVE) against DOX-induced toxicities in rats. In addition, the inhibitory activities of three phytochemical compounds (Rutin, Gallic acid and Rosmarinic acid) from CVE against Carbonyl reductase 1 (CBR1) were examined.

Methods
Rats were randomly divided into 5 groups: (a) Control group rats were given 0.9% NaCl as vehicle, (b) DOX group: A single dose of DOX (25 mg/kg; i.p.) was administered and rats were sacrificed 4 days after DOX injection, while groups (c–e) CVE-treated DOX rat groups were given 125, 250 and 500 mg/kg body weight of extracts orally for 12 consecutive days; 8 days before, and 4 days after the DOX administration. Computational techniques were used to determine the inhibitory activities of the compounds against CBR1.

Results
DOX intoxication caused a significant increase (p<0.05) in serum marker enzymes: ALT, AST, ALP, LDH, CK activities. The levels of liver and heart tissues antioxidant parameters: GPx, SOD, CAT, and GSH were significantly (p<0.05) decreased in DOX-intoxicated rats with concomitant elevation of malondialdehyde levels. Pretreatment with CVE reversed the above trends. From the structural analysis, Rutin and RSA exhibited the highest binding free energies against CBR1, and also exhibited structural stability when bound with CBR1.

Conclusions
Our study indicates the protective effect of CVE when used in combination with doxorubicin thus improving its chemotherapeutic application via inhibition of CBR-mediated metabolism.
Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
Authors: Ahmed Noor Zaheer , Agibothu Kupparam Hemanth Kumar , Akbar Seema , Hissar Syed , Anwar Noman , Thiruvengadam Kannan , Anjum Nighat , Khan Asim Ali , Dar Showkat , Natarajan Saravanan 
Published: May 2021

Abstract

Objectives
Tuberculosis continues to be a major public health problem globally, despite incredible advancements in healthcare system. In Unani system of medicine, Qurs Tabasheer Sarthani (QTS) and Arq Hara Bhara (AHB) have been traditionally used for tuberculosis like conditions. The study was aimed to investigate the effects of co-administration of QTS and AHB with category I first line antitubercular drugs (CAT-I) on the indices of liver and kidney function in rats.

Methods
QTS and AHB were prepared individually and mixed to achieve final compound Unani pharmacopoeia formulation (UPF). The human equivalent doses for rats were calculated and administered with and without CAT-I. The effects of the formulations on serum indices of kidney and liver function, hematological markers and plasma CAT-I drug levels were estimated at 14th, 60th & 180th days of treatment.

Results
The administration of UPF, CAT-I and UPF + CAT-I altered the levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT) and haematological markers. These alterations were within permissible range and randomly distributed among groups during various time points. Administration of CAT-I alone resulted in moderate histopathological changes which were completely abrogated in CAT-I + UPF co-administered animals. The co-administration of UPF with CAT-I improved the plasma peak rifampicin (RIF) levels, without altering the liver and kidney functions.

Conclusions
The co-administration of UPF with ATT improved liver and kidney functions and increased the plasma levels of RIF. These beneficial findings provide a scope to evaluate the pharmacokinetic studies in humans.
Uterine contractile activity and fetal outcome in rats treated with vitamin C during late gestational variable stress exposure
Authors: Salami Shakiru A. , Salahdeen Hussein M. , Obafemi Abidemi E. , Murtala Babatunde A. 
Published: May 2021

Abstract

Objectives
Stress responses vary throughout pregnancy and impact of late gestational variable stress (LGVS) with vitamin C supplementation on uterine contractility is barely explored. This study investigates fetal weight outcome and in-vitro uterine contractile responses to pharmacological agents during LGVS exposure.

Methods
Twenty four nulliparous pregnant rats were divided into four groups of six. During gestation days 10–19, groups 1 & 2 received normal saline and vitamin C (10 mg/kg) respectively. Groups 3 and 4 were exposed to stress (sleep deprivation, predator exposure, immobility, rapid cage changes, noise, and foreign object) with group 4 concurrently supplemented with vitamin C (10 mg/kg). Serum cortisol, oxidative bio-markers, fetal weights and in-vitro contractile responses of excised uterine tissue to acetylcholine (Ach), oxytocin, calcium chloride (CaCl2), potassium chloride (KCl), diclofenac, and magnesium ions were determined.

Results
Malondialdehyde activity and cortisol were significantly increased in variable stress only exposed group when compared with control and vitamin C supplemented groups. Fetal body weights, superoxide dismutase and catalase activity were significantly reduced in variable stress only exposed group. Significantly impaired contractile responses to Ach, CaCl2 & KCl in variable stress only exposed group were modulated in vitamin C supplemented groups. Impaired contractile response to oxytocin was however not reversed. Relaxation responses to diclofenac and magnesium ions were statistically unaltered across groups.

Conclusions
Impaired fetal weights and uterine contractile activity to Ach, CaCl2 and KCl during LGVS was modulated by vitamin C supplementation. Impaired oxytocin contractile activity was however unreversed.
Identification of common features within massage therapists’ professional identity
Authors: Baskwill Amanda , Vanstone Meredith , Harnish Del , Dore Kelly 
Published: May 2021

Abstract

Objectives
In Ontario, Canada, MTs are regulated and have a common scope of practice. However, diverse practice settings and approaches to care create a need for MTs to articulate their professional identity. This study sought to answer, “what common features are foundational to the professional identity of MTs in Ontario?”

Methods
This quantitative research study was a part of a larger exploratory sequential mixed methods study. An online questionnaire-based cross-sectional study was conducted based on previous qualitative findings. MTs in Ontario, who held an active certificate, were invited to participate. Data were analyzed using descriptive statistics.

Results
The analysis revealed 17 common features that were endorsed by most respondents. Participants also reported thinking of themselves as healthcare professionals, rather than service providers, a feeling that was held across practice settings. Interesting and unexpected differences were noted in statements regarding the perception of MTs, areas of profession-specific knowledge, and the establishment of the therapeutic relationship.

Conclusions
This study furthers an understanding of MTs’ identity. Specifically, MTs consider themselves to be HCPs who are confident in their knowledge and abilities, especially their communication skills. They believe in providing individualized care and empowering their patients to take charge of their own health. Despite areas of overwhelming agreement, disagreement in endorsement was seen in areas such as MTs perception of their external image, use of evidence in practice, and the establishment of professional boundaries. These areas provide an opportunity for future research to continue to develop a body of knowledge regarding MTs professionalism and identity.
Antilithiatic activity of a non-pharmacopoeial Unani formulation in chemically induced urolithiasis in rats
Authors: Parveen Rehana , Wadud Abdul , Shamsi Shariq , Parveen Shaista 
Published: May 2021

Abstract

Objectives

Parshioshan (Adiantum capillus-veneris L.), Duqu (Peucedanum grande C.B. Clarke), Kaknaj (Physalis alkekengi L.) and Kharekhasak (Tribulus terresteris L.) have been selected for this study as they have been associated with medicinal actions for litholytic activity.

Methods
The experiment was carried out in Sprague Dawley rats divided into seven groups, serving as plain control, disease control, standard control, curative A and B and preventive A and B groups. Animals of plain control received distilled water. Remaining six groups received Ethylene glycol 0.75% and Ammonium chloride 1% by adding in the drinking water for the first three days followed by 0.75% Ethylene glycol for 18 days. From 8th day till 21st day, standard control received Cystone in the dose of 750 mg/kg. Preventive and curative test groups were treated with hydroalcoholic extract of the test drug in the dose of 132 mg/kg and 264 mg/kg from 1st to 21st day and 8th to 21st day of calculi induction.

Results
Test drug reduced the number of calcium oxalate crystals in the urine; the level of urinary calcium, creatinine, magnesium, phosphorus, sodium and chloride decreased significantly in standard and test groups. The urine volume increased significantly in all the test groups. The level of serum calcium, urea, phosphorus and creatinine were significantly reduced in all the test groups.

Conclusions
These results indicated that the test drug reduced and prevented the growth of urinary stones. Moreover, the test drug also possessed significant antiurolithiatic activity. However, the protective effect was found more than its curative effect.
Void-hole aware and reliable data forwarding strategy for underwater wireless sensor networks
Authors: Mahdi Omar Adil , Ghazi Ahmed Basil , Al-Mayouf Yusor Rafid Bahar 
Published: May 2021

Abstract
Reliable data transfer and energy efficiency are the essential considerations for network performance in resource-constrained underwater environments. One of the efficient approaches for data routing in underwater wireless sensor networks (UWSNs) is clustering, in which the data packets are transferred from sensor nodes to the cluster head (CH). Data packets are then forwarded to a sink node in a single or multiple hops manners, which can possibly increase energy depletion of the CH as compared to other nodes. While several mechanisms have been proposed for cluster formation and CH selection to ensure efficient delivery of data packets, less attention has been given to massive data communication processes with sink node. As such, failure in communicating nodes would lead to a significant network void-holes problem. Considering the limited energy resources of nodes in UWSNs along with the heavy load of CHs in the routing process, this paper proposes a void-holes aware and reliable data forwarding strategy (VHARD-FS) in a proactive mode to control data packets delivery from CH nodes to the sink in UWSNs. In the proposed strategy, each CH node is aware of its neighbor’s performance ranking index to conduct a reliable packet transmission to the sink via the most energy-efficient route. Extensive simulation results indicate that the VHARD-FS outperforms existing routing approaches while comparing energy efficiency and network throughput. This study helps to effectively alleviate the resource limitations associated with UWSNs by extending network life and increasing service availability even in a harsh underwater environment.