bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimalarial Drug Discovery: From Quinine to the Most Recent Promising Clinical Drug Candidates
Authors: Tisnerat Camille , Dassonville-Klimpt Alexandra , Gosselet Fabien , Sonnet Pascal 
Published: August 2021

Abstract:Malaria is a tropical threatening disease caused by Plasmodium parasites, resulting in 409,000 deaths in 2019. The delay of mortality and morbidity has been compounded by the widespread of drug resistant parasites from Southeast Asia since two decades. The emergence of artemisinin-resistant Plasmodium in Africa, where most cases are accounted, highlights the urgent need for new medicines. In this effort, the World Health Organization and Medicines for Malaria Venture joined to define clear goals for novel therapies and characterized the target candidate profile. This ongoing search for new treatments is based on imperative labor in medicinal chemistry which is summarized here with particular attention to hit-to-lead optimizations, key properties, and modes of action of these novel antimalarial drugs. This review, after presenting the current antimalarial chemotherapy, from quinine to the latest marketed drugs, focuses in particular on recent advances of the most promising antimalarial candidates in clinical and preclinical phases.
Copper-Catalyzed Cross-Coupling Between (E)-1,2-Diiodoethene and
Carbazates: Entry to β-Functionalized N-Alkenylcarbazates
Authors: Casault Paméla , Ricard Simon , Daoust Benoit 
Published: August 2021

Aims:
This work aims to widen the scope of methodologies to prepare functionalized
N-alkenylcarbazates.

Background:
Alkenylcarbazates are generally prepared via Aza-Baylis-Hillman reactions, nucleophilic
attack on ketones or a tandem carbometallation/amidation reaction of alkynes.

Objective:
The objective of this work is to develop a method to prepare functionalized Nalkenylcarbazates
that alleviates the problem encountered in the above methods (use of electron
deficient alkenes, use of stoiechiometric amounts of metal, access to symmetrical dicarbazates only).

Methods:
Use of copper-catalyzed cross-coupling between vinylic diiodide and carbazates to prepare
functionalized N-alkenylcarbazates.

Results:
Various β-iodovinylcarbazates were synthesized with up to good yields. The highest
yields were obtained using dicarbazates. Functionalization of β-iodovinylcarbazate demonstrated
that the vinyl iodide moiety of these molecules can be substituted by a variety of functional
groups via transition metal-catalyzed coupling reactions.

Conclusion:
Copper-catalyzed cross-coupling reaction is efficient to prepare functionalized
N-alkenylcarbazates.
Synthesis, Characterization, Antitumor Potential, BSA and DNA Binding
Properties, and Molecular Docking Study of Some Novel 3-Hydroxy-3-
Pyrrolin-2-Ones
Authors: Joksimović Nenad , Petronijević Jelena , Milović Emilija , Janković Nenad , Baskić Dejan , Popović Suzana , Todorović Danijela , Matić Sanja , Vraneš Milan , Tot Aleksandar 
Published: August 2021

Background:
In order to make progress in discovering the new agents for cancer treatment
with improved properties and considering the fact that 3-hydroxy-3-pyrrolin-2-ones belong to a
class of biologically active compounds, we tested series of eleven novels 1,5-diaryl-4-(2-
thienylcarbonyl)-3-hydroxy-3-pyrrolin-2-ones for their antitumor potential.

Methods:
All novel compounds were characterized by spectral (IR, NMR, MS) and elemental analysis.
All novel 3-hydroxy-3-pyrrolin-2-ones were screened for their cytotoxic activity on two cancer
cell lines, SW480 and MDA-MB 231, and non-transformed fibroblasts (MRC-5).

Results:
Compounds B8, B9, and B10 showed high cytotoxicity on SW480 cells together with good
selectivity towards MRC-5 cells. It is important to empathize that the degree of selectivity of B8 and
B10 was high (SI = 5.54 and 12.09, respectively). Besides, we explored the mechanisms of cytotoxicity
of novel derivatives, B8, B9, and B10. The assay showed that tested derivatives induce an apoptotic
type of cell death in SW480 cells, with a minor percent of necrotic cells. Additionally, to better
understand the suitability of the compounds for potential use as anticancer medicaments, we studied
their interactions with biomacromolecules (DNA or BSA). The results indicated that the tested compounds
have a great affinity to displace EB from the EB-DNA complex through intercalation. Also,
DNA and BSA molecular docking study was performed to predict the binding mode and the interaction
region of the compounds.

Conclusion:
Achieved results indicate that our compounds have the potential to become candidates
for use as medicaments.
DEPRESIÓN EN ESTUDIANTES DE ENSEÑANZA MEDIA PÚBLICA, SEVERIDAD, GÉNERO Y EDAD
Authors: Cajigas-Segredo Nelda , Kahan Evelina , Luzardo Mario , Ugo María del Carmen 
Published: August 2021

Se administró a seiscientos estudiantes de 11 a 17 años de nivel socio-económico medio-bajo de un liceo público del Montevideo suburbano, el Children’s Depression Inventory (CDI, Kovacs) tomado de la traducción y validación españolas y factorizado y validado en Uruguay por estos autores con propiedades psicométricas mayoritariamente satisfactorias. La prevalencia de la depresión alcanzó un 15% de la muestra. Con respecto al género, se confirmaron puntuaciones más altas en las chicas en la Puntuación Global y las dimensiones identificadas. Solamente el factor Ineficacia se presenta independiente del género sugiriendo una problemática adolescente específica. La depresión evoluciona dependiendo del género y aumenta significativamente con la edad consistentemente con parte de la literatura que destaca un incremento en la población femenina posterior a los 12 años. Aunque no hay diferencia ínter género en los estudiantes no deprimidos, entre los moderados y severamente deprimidos, las chicas son el doble de los varones con variaciones por factor.
Second-Line Therapy for Type 2 Diabetes Management: The Treatment/Benefit Paradox of Cardiovascular and Kidney Comorbidities
Authors: McCoy Rozalina G. , Van Houten Holly K. , Karaca-Mandic Pinar , Ross Joseph S. , Montori Victor M. , Shah Nilay D. 
Published: August 2021

OBJECTIVE
To examine whether glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) are preferentially initiated among patients with cardiovascular disease, heart failure (HF), or nephropathy, where these drug classes have established benefit, compared with dipeptidyl peptidase 4 inhibitors (DPP-4i), for which corresponding benefits have not been demonstrated.

RESEARCH DESIGN AND METHODS
We retrospectively analyzed claims of adults with type 2 diabetes included in OptumLabs Data Warehouse, a deidentified database of commercially insured and Medicare Advantage beneficiaries, who first started GLP-1RA, SGLT2i, or DPP-4i therapy between 2016 and 2019. Using multinomial logistic regression, we examined the relative risk ratios (RRR) of starting GLP-1RA and SGLT2i compared with DPP-4i for those with a history of myocardial infarction (MI), cerebrovascular disease, HF, and nephropathy after adjusting for demographic and other clinical factors.

RESULTS
We identified 75,395 patients who started GLP-1RA, 58,234 who started SGLT2i, and 91,884 who started DPP-4i. Patients with prior MI, cerebrovascular disease, or nephropathy were less likely to start GLP-1RA rather than DPP-4i compared with patients without these conditions (RRR 0.83 [95% CI 0.78–0.88] for MI, RRR 0.77 [0.74–0.81] for cerebrovascular disease, and RRR 0.87 [0.84–0.91] for nephropathy). Patients with HF or nephropathy were less likely to start SGLT2i (RRR 0.83 [0.80–0.87] for HF and RRR 0.57 [0.55–0.60] for nephropathy). Both medication classes were less likely to be started by non-White and older patients.

CONCLUSIONS
Patients with cardiovascular disease, HF, and nephropathy, for whom evidence suggests a greater likelihood of benefiting from GLP-1RA and/or SGLT2i therapy, were less likely to start these drugs. Addressing this treatment/benefit paradox, which was most pronounced in non-White and older patients, may help reduce the morbidity associated with these conditions.
Análisis y diagnóstico estratégico del Centro de Gestión Tecnológica de Servicios: un ejercicio de prospectiva tecnológica
Authors: Castrillón Córdoba Michelle , Rincón Guerrero Gustavo Enrique 
Published: August 2021

La prospectiva estratégica y la visión a largo plazo, en el campo organizacional y en el desarrollo de los territorios ha venido tomando mayor fuerza en las últimas décadas, debido a los constantes cambios que impactan directa o indirectamente el desarrollo de una organización o territorio, a la necesidad de garantizar sostenibilidad en el tiempo y a la baja capacidad de previsión de algunas áreas de conocimiento para ofrecer modelos que se ajusten a la realidad y acierten en sus previsiones. Estas razones justifican cada vez más la utilización de modelos prospectivos en la planeación estratégica de las organizaciones y territorios a nivel mundial.
Es así como, este documento presenta un diagnóstico estratégico a partir de la implementación de métodos prospectivos, que aporta a la confrontación asertiva de los retos en materia social, económica y tecnológica a los que se enfrenta el Centro de Gestión Tecnológica de Servicios (CGTS) Regional Valle como centro de formación del SENA. A su vez, este ejercicio hace parte del trabajo prospectivo que se ha venido realizando en este centro de formación para la construcción de un Plan de Desarrollo Tecnológico con horizonte 2019-2029 que representa un compromiso de mejora continua sobre el ejercicio de planeación institucional donde se establecen estrategias, proyectos estratégicos, alianzas que permitan el cumplimiento y la articulación entre cada uno de ellos.
Systematic Review on Modern Learning Approaches, Critical Thinking Skills and Students Learning Outcomes
Authors: Hafeez Muhammad 
Published: August 2021

The popularity of the internet for using modern and digital learning approaches replaced the old and conventional teaching methods. By applying ICT, an ideal learning environment can be created between students and teachers. The main objective of this review article is to review various dynamic approaches to learning and learning approaches to critical thinking skills and student learning outcomes. This type of research is qualitative. The current investigation was led using enlightenment strategies accumulated by library procedures, which were collected considering educational innovations, related issues, and referenced books. The study results indicate that learning approaches such as Game and Computer-Based or Mobile Based learning approaches are more effective and skilled than conventional learning approaches. Collaborative learning approaches such as Case-Based, Project-Based, and Problem Based learning approaches are very constructive for communication, learning outcomes, and analytical thinking skills. So, a practical and newly developed learning approach should be applied to student learning outcomes of high-level critical thinking and communication skills.
Hubungan Konsep Diri dan Kepercayaan Diri Dengan Hasil Belajar Simulasi Komunikasi dan Digital Siswa
Authors: Hafizah Husnal , Ambiyar Ambiyar 
Published: August 2021

Hasil belajar siswa pada pelajaran simulasi komunikasi digital kelas X TKJ masih banyak yang belum mencapai KKM. Penelitian ini bertujuan untuk menganalisis hubungan konsep diri dan kepercayaan diri dengan hasil belajar simulasi komunikasi dan digital siswa kelas X TKJ SMK. Jenis penelitian adalah kuantitatif dengan pendekatan korelasional. Populasi penelitian ini adalah semua siswa kelas X TKJ di SMK. Populasi penelitian berjumlah 35 siswa. Pengambilan sampel dalam penelitian ini dilakukan dengan cara total sampling dengan jumlah sampel 35. Instrumen pengumpulan data menggunakan kuisioner menggunakan Skala Likert, teknik analisis data diantaranya korelasi sederhana dan korelasi berganda. Hasil penelitian menunjukkan bahwa terdapat hubungan yang positif dan signifikan antara konsep diri dengan hasil belajar yang kuat, terdapat hubungan yang positif dan signifikan antara kepercayaan diri dengan hasil belajar yang kuat dan terdapat hubungan yang positif dan signifikan antara konsep diri dan kepercayaan diri dengan hasil belajar yang kuat. Penelitian diharapkan dapat meningkatkan hasil belajar melalui peningkatan konsep diri positif dan kepercayaan diri yang potif, sehingga siswa terdorong melakukan kegiatan yang positif dalam belajar.
Aplikasi Lembar Kerja Peserta Didik Berbasis Stem pada Materi Gerak Melingkar
Authors: Rahmayani Fadillah , Hendri Menza , Rasmi Dian Pertiwi 
Published: August 2021

Pembelajaran yang seharusnya berpusat pada peserta didik tidak sepenuhnya diberlakukan, hal ini disebabkan masih ada beberapa guru yang tetap mengajar peserta didik dengan metode pembelajaran konvensional yang mana pembelajaran tersebut menempatkan peserta didik sebagai objek dan guru sebagai subjek. Tujuan penelitian ini untuk mengembangkan produk berupa Aplikasi Lembar Kerja Peserta Didik Berbasis STEM agar dapat menunjang pembelajaran siswa menjadi lebih menarik. Metode penelitian yang digunakan adalah Research and Development (R&D) dan menggunakan model pengembangan ADDIE (Analisis, Desain, Development, Implemetasi, dan Evaluasi). Subjek uji coba dalam pengembangan LKPD Android berbasis STEM ini adalah siswa-siswa SMA. Metode pengumpulan data menggunakan kuisioner, wawancara, observasi. Data dianalisis menggunakan Statistik deskriptif. Hasil produk divalidasi oleh validator ahli dan validator media diperoleh hasil dengan rata-rata 3,24 dalam kategori sangat baik untuk ahli materi dan 3, 27 hasil dari ahli media dengan kategori sangat baik. Uji kelompok kecil angket responden dan diperoleh hasil Produk yang dikembangkan memiliki rata-rata skor 3,26 dimana termasuk dalam kategori Sangat Baik, Sehingga Produk yang dihasilkan dapat dikategorikan sangat baik dan layak untuk digunakan. Implikasi penelitian ini diharapkan dapat membantu siswa dalam belajar dan meningkatkan hasil belajar siswa.
Survival Analysis of Hospitalized Liver Cirrhotic Patients in Jakarta: 2 Years Follow Up Study
Authors: Gani Rino Alvani 
Published: August 2021

Background: The incidence of liver cirrhosis in Indonesia is increasing over time. In this study, we aim to present a 2-year survival analysis on liver cirrhotic patients using Child-Pugh and MELD score and also analyzing the most common cause of death among liver cirrhotic patients.Method: A retrospective cohort study was used by evaluating the medical records of patients who went to internal medicine ward of Cipto Mangunkusumo Hospital during the period between 2011-2016. The inclusion criteria were all cirrhotic patient registered with a completely filled medical record. The exclusion criteria were the presence of Hepatocellular carcinoma, cholangiocarcinoma, and other form of malignanciesResults: A total of 89 patients were included in this study. The total of 75.3% of the patients were dead during the 2 years follow up with the most prevalent cause of death (COD) being infection (45.5%). Survival analysis, showed that the survival of CP Class A were significantly better than B and C. The cut off value for 2-years mortality was CP score 7 and MELD score 9 in liver cirrhotic patientsConclusion: The mortality rate of liver cirrhotic patients is very high with infection as the main COD. Patients with Child-Pugh score B and C have worse prognosis than Child-Pugh score A.
Diversity of Family Myrtaceae Juss. 1789 in Ha Tinh Province
Authors: Khanh Tran Hau , Ban Pham Hong , Hoi Tran Minh 
Published: August 2021

The study result of Myrtaceae family in Ha Tinh province reported, 61 species of 13 genera. In of them 36 species and 6 genera have been added to the list of Ha Tinh province (2021). The family myrtaceae in Ha Tinh province has many different uses: 61 species for essential oils, 46 species for timber plants, 30 species for medicinal plants, 24 species for edible, 11 species for ornamental plants, 7 species for different uses and 4 species for tannin plants. In the stems form, the large groups of trees with 10 species, followed by average groups of trees with 15 species; small of trees dominated with 26 species and groups of shrubs 10 species. There are 4 major habitats: forest with 35 species (57.38%), light forest with 35 species (57.38%), subforest with 50 species (81.97%), along streams and beside the road with 35 species (57.38%).
Language Style in Poetry Mahmud Sami Basha al–Barudi (A Stylistic Analysis) | Gaya Bahasa dalam Puisi Mahmud Sami Basha al–Barudi (Suatu Analisis Stilistik)
Authors: Najah Zughrofiyatun , Hijriyah Umi , Mizan Ahmad Nur , Amalia Dian Risky 
Published: August 2021

This study aims to examine the language style (al–uslub) used by al- Barudi in his poetry with the theme of life descriptions by describing the main idea or theme, elements of feeling or emotion, and language style based on aspects of diction or choice of words, syntax or sentence structure and rhetorical aspect or meaning. This research is a type of qualitative research with a descriptive-analytical literature study by referring to Al-Barudi's poetry text as the primary source. The data analysis method used is content analysis (tahlil al–madmun). The author uses a stylistic approach in examining and analyzing the language styles used by the poets in this poem. In examining this poem, the writer will use the stylistic theory proposed by Gorys Keraf related to the classification of types of diction, language style based on syntactic aspects, and rhetorical aspects or meaning. This poetry has the theme of "life description" with a choice of words that still maintain aesthetic values supported by a very strong language style or (al–uslub). The language style contained in the poem is very strong and appropriate with the characteristics of the neoclassical genre of poetry pioneered by al-Barudi at that time, although free, but still strongly adheres to wazan and qafiyah. Seen from the aspect of diction, the words chosen by the poet in sya'ir are quite easy to understand in a popular style. Then from the aspect of sentence structure or syntax, this poem has a climax style. The language styles based on the meaning contained in this poem are hyperbole, simile, pleonasm, apostrophe, ellipsis, assonance, erotesis, and euphemism.
What a patient needs to know about the virus human papillomas and cervical cancer?
Authors: Sinchikhin Sergei P. , Stepanyan Lusine V. 
Published: August 2021

According to experts of the World Health Organization, cervical cancer is the only cancer that can be completely prevented through the introduction of mass screening and educational information in the population. One of the activities of the obstetrician-gynecologist is the conduct of health education. However, for a variety of reasons, a practical doctor may have difficulty preparing for informational and educational meetings with patients.
Aim. To prepare a clinical lecture for the obstetrician-gynecologist, which can be used in educational work with the population on the prevention of human papillomavirus infection and cervical cancer.
Materials and methods. The information material includes data from foreign and domestic scientific articles available at PubMed on this topic and published over the past 10 years.
Results. A systematic analysis of the data contained in the modern literature on human papillomavirus, human papillomavirus infection and cervical cancer has been carried out. Information is presented on the prevalence of diseases, diagnostic methods, and features of the course of human papillomavirus infection, the role of human papillomavirus in the development of cervical cancer. Attention is drawn to the importance of preventive examinations. Part of the information is presented in the form of answers to patients questions, which makes the information presented especially memorable.
Conclusion. It is hoped that the prepared lecture will be useful for the educational work of the obstetrician-gynecologist and will increase the educational information of the population on the prevention of cervical cancer.
Un Relato Kimbandista, Umbandista y Batuqueiro desde Argentina
Authors: Di Baja Maria Azul 
Published: August 2021

El textro propone un breve relato contado en primera persona por parte de la Mae Pequeña de la casa de Santo "Ilé Nueva Conciencia" en Argentina, quién cuenta su tránsito en el culto Afrobrasilero, el vínculo con los orixás, las entidades, sus hermanos y su Mae y cómo éstos la fueron acompañando en su crecimiento tanto en el plano terrenal y espiritual ocupándo un lugar fundamental en su proceso de maduréz.
Das Águas Ìyá Oxum: saberes ancestrais femininos em poesias negras diaspóricas
Authors: Sales Cristian 
Published: August 2021

Neste artigo, investimos numa discussão acerca dos saberes ancestrais femininos articulados em poesias negras diaspóricas. Dessa maneira, ao apresentar um estudo crítico dos poemas de Lívia Natália e Paula Melissa (Mel Adún), observamos como os arquétipos de Ìyá Oxum são incorporados como tessituras e fundamentos epistêmicos. A partir de contribuições teóricas formuladas na filosofia africana, o texto explora como o orixá feminino Oxum se torna uma “categoria sócio-espiritual” (OyÄ›wùmí, 2016) de abertura para uma transformação epistemológica para ver, sentir e compreender o mundo, em contraposição ao pensamento ocidental.
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Materiais didáticos para o ensino de física no nível fundamental por meio de plataformas eletrônicas
Authors: Evangelista Fábio Lombardo 
Published: August 2021

Este trabalho propõe uma sequência didática composta por 4 encontros para trabalhar o conteúdo ”momento de alavanca“ no ensino fundamental e introdução Ã lógica de programação. Pode ser aplicado a estudantes do 5o ao 9o ano do ensino fundamental. As aulas foram instrumentalizadas por um braço robótico construído em impressora 3D e controlado pela tecnologia Arduino. Também houve o estudo da lógica de programação, mediante o uso do programa computacional Scratch, instalado em uma plataforma eletrônica Raspberry Pi. A mediação sugerida visa promover cinco relações pedagógicas: aluno-professor, aluno-aluno, aluno-ambiente, aluno-saber científico e aluno-tecnologia. Com a aplicação da sequência didática proposta, pode-se perceber que as relações citadas, além de motivar os alunos, permitem uma considerável influência na reelaboração conceitual dos assuntos estudados e uma melhor compreensão da lógica de programação.
Ensino e aprendizagem de eletrostática utilizando os três momentos pedagógicos de Delizoicov e Angotti
Authors: Barreto Pâmella Gonçalves , Sales João Pedro Almeida , De Araújo Lídia Cruz , Maia Phablo Henrique Duarte , Lobo Matheus Pereira 
Published: August 2021

Considerando a perspectiva de como trabalhar os conceitos de eletrostática em sala de aula de forma a construir o conhecimento e avaliar o grau de aprendizagem dos alunos, objetiva-se nesse artigo analisar duas aulas aplicadas para alunos da terceira série do ensino médio com a temática eletrostática, levando-se em conta os três momentos pedagógicos de Delizoicov e Angotti como estrutura de planejamento de aula. Para tanto, procede-se Ã estruturação da aula em: problematização inicial, organização do conhecimento e aplicação do conhecimento, junto com a utilização de um quiz como avaliação do aprendizado. Desse modo, observa-se que a metodologia se mostrou eficaz quando analisamos os dados do diário de bordo e a aplicação do quiz.