bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived changes in capability during the COVID-19 pandemic: A Swedish cross-sectional study from June 2020
Authors: Meili Kaspar Walter , Jonsson Håkan , Lindholm Lars , Månsdotter Anna 
Published: July 2021

Aims: Measures against COVID-19 potentially impact quality of life in different ways. The capability approach by Amartya Sen with a broad and consistent framework for measuring quality of life is suited to capture the various consequences. We aimed to examine (a) whether individuals experienced change in 10 capability dimensions during the first half of 2020, (b) which dimensions were affected most, and (c) whether changes were unequally distributed in terms of gender, education, income, geography, housing, living situation and place of birth. Methods: We assessed self-reported capability change in Sweden in 10 capability dimensions in a cross-sectional online survey among 500 participants on a five-item Likert scale. We analysed the distribution of answers by comparing the balance of positive and negative perceived changes and used mixed effects logistic regression to examine associations with background characteristics of the participants. Results: Reported perceived negative changes outweighed positive changes, and a higher proportion stated negative perceived changes if they also stated having low capability in the same dimension. In the capabilities of financial situation, political resources and health, the proportions of perceived negative change were highest. Odds for perceived negative change compared to no or positive change were higher for lower incomes, living in smaller municipalities compared to living in medium-sized municipalities, being born outside Europe, living in the south of Sweden, and renting instead of owning housing. Conclusions: Self-reported negative capability change, and associated inequalities related to socioeconomic position, place of birth and regional residence should be of concern for policymakers.
Study design: Pathways to Independence – A study of unaccompanied minor refugees settled in a Norwegian city municipality
Authors: Kvestad Ingrid , Randal Sølve Bjørn , Sayyad Nawar , Lehmann Stine , Bøe Tormod 
Published: July 2021

Aims: The aim of the ‘Pathways to Independence’ study was to gain knowledge of how to facilitate a healthy development for unaccompanied refugee minors (URMs) after settling in Norwegian municipalities. Methods: The project is located in the URM child welfare services (URM CWS) of the Bergen municipality. We invited 101 URMs older than 15 years connected to the URM CWS to participate in a comprehensive survey. Of the invited, 81 consented to participate. The survey included questions on the user’s experiences and satisfaction with the URM CWS, and questions related to schooling, social support and activities after settlement. We also included standardized and validated questionnaires on potential traumatic events, mental and somatic health, protective factors and quality of life. These questionnaires have previously been used in two Norwegian epidemiological studies, the ‘Youth@Hordaland’ and ‘Young in Foster care’, facilitating comparison of the results with other youth populations in Norway. Conclusion: Results from the project will be valuable in the process of reaching knowledge-based recommendations for successful settlement of URMs.
Fast triethylamine gas sensing performance based on In2O3 nanocuboids
Authors: Wang He , Zhao Hongwei , Li Sirui , Zhu Hang , Zhou Liming , Zhang Hehan , Xu Huilei , Yang Tianye 
Published: July 2021

A simple solvent thermal method and subsequent annealing process were adopted in the successful synthesis of In2O3 nanocuboids. Outstanding sensing performance is demonstrated in the prepared In2O3-based sensor including relative low working temperature (180 °C) and high response value ∼30 toward 20 ppm triethylamine. Excellent triethylamine sensor performance is due to the unique configuration of nanocuboids and a large number of oxygen vacancies in In2O3 nanocrystals, thus improving gas sensitivity. Furthermore, the triethylamine sensing mechanism and potential growth mechanism are also studied.
Open versus Endovascular Abdominal Aortic Aneurysm Repair in the Australian Private Sector Over Twenty Years
Authors: Qin Kirby R. , Perera Marlon , Papa Nathan , Mitchell David , Chuen Jason 
Published: July 2021

Purpose Over the past two decades, the proliferation of endovascular surgery has changed the approach to abdominal aortic aneurysm (AAA) repair. In Australia, close to two-thirds of surgical procedures are performed in the private healthcare system. We aimed to describe the trends in AAA repair in the Australian private sector throughout the early 21st century. Materials and Methods Medicare Benefits Schedule (MBS) statistics were accessed to determine the number of infrarenal open AAA repair (OAR) and endovascular AAA repair (EVAR) procedures performed between January 2000 and December 2019. Population data were extracted from the Australian Bureau of Statistics and used to calculate incidence per 100,000 population. Further analysis was performed according to age, gender, and state. Results During the study period, 13,193 (67.0%) EVARs and 6504 (33.0%) OARs were performed in the Australian private sector. OARs fell from 70.5% (n=567) of AAA repairs in 2000 to 15.7% (n=237) in 2019, while EVARs rose from 29.5% (n=151) to 84.3% (n=808). The frequency of EVAR surpassed OAR in 2004. The overall incidence of AAA repair varied minimally over the time period (range: 4.9–6.5 per 100,000 adults per year). AAA repair was more common in males than females (9.7 vs 1.7 per 100,000 population) and more common in older age groups. There was a 4-fold increase in EVAR among males older than 85 years (12.8–57.4 per 100,000 population), the largest rise of any group. The overall EVAR:OAR ratio increased from 0.4 to 5.4. There were considerable state-based discrepancies. Conclusion The landscape of AAA repair in Australian private sector has drastically changed with a clear preference toward EVAR. EVAR saw increased use across all genders, age groups and states, despite stable rates of AAA surgery. Further research is necessary to compare our findings to national trends in the Australian public sector.
Percutaneous Retrieval of Venous Bullet Embolism
Authors: Peiffer Brock , Huang Junjian , Shah Rohan , Saker Mark 
Published: July 2021

Purpose Bullet fragment embolization is a rare but potentially fatal complication of traumatic gunshot injury. Herein, we present a case of a patient who demonstrated migration of a bullet fragment from the lower chest into the left common iliac vein. Continual identification of foreign bodies on trauma imaging is of the utmost importance. Identifying and treating this rare entity can help vascular interventionalists improve patient outcomes. Case Report Our patient presented to the emergency room after sustaining 2 gunshot wounds to the right axilla. Initial imaging demonstrated 2 bullet fragments: one in the right axilla and another in the lower chest overlying the heart. A subsequent trauma computed tomography was performed 13 minutes later and demonstrated a bullet fragment in the left common iliac vein, which had embolized from the original location in the lower chest. Interventional radiology was consulted to perform foreign body removal. A transcutaneous approach was utilized, and the bullet embolus was removed successfully without complication. Conclusion Bullet fragment embolization is a rare entity with complications ranging from critical limb ischemia to venous thrombosis or obstruction. This case helps to demonstrate the importance of identifying and accounting for bullet fragments in gunshot trauma imaging.
Operative Treatment of Distal Radius Fractures in Patients With Parkinson Disease
Authors: Logli Anthony L. , Rizzo Marco 
Published: July 2021

Background: Owing to the many unique disease characteristics of Parkinson disease (PD)—namely resting tremors, muscular rigidity, and poor bone quality—we hypothesized that this patient population would have inferior outcomes with surgical management of acute distal radius fractures (DRFs) compared with the literature available on the general population. Methods: This is a retrospective observational study performed at a single, level 1, academic center from 2001 to 2020 capturing all adult patients with an isolated, acute, and closed DRF that ultimately underwent operative treatment. International Classification of Diseases 10 codes were used to identify 30 patients for manual chart review. Several patient and fracture characteristics were accounted for and complications, reoperations, and failures of surgical intervention were recorded. Results: There was a total of 7/30 failures (23%), 6/30 reoperations (20%), and 12 complications in 9/30 wrists (complication rate, 30%) at a mean latest follow-up of 11 months (1.2-158 months). Of the 7 failures, 5 were due to loss of reduction, and 2 of them were deep infections with mean time to failure of 8.3 weeks (range, 11 days-5.2 months). Conclusions: This study found a high rate of complications, reoperations, and early failure despite a short follow-up period and a small cohort of patients with PD treated surgically for a DRF. We recommend locked plating if suitable for the fracture type and early involvement of a multidisciplinary team to assist with medical optimization of PD to increase chances of a successful outcome.
Use of Cross-sectional and Perspective Mapping to Spatially and Statistically Represent Inpatient Glucose Control
Authors: Saulnier George E. , Castro Janna C. , Mi Lanyu , Cook Curtiss B. 
Published: July 2021

Background: The use of inpatient location for the depiction of glycemic control is an alternative approach to the traditional analysis of hospital-derived glucometric data. Our aim was to develop a method of spatial representation and to test for corresponding statistical variation in inpatient glucose control data. Methods: Point-of-care blood glucose data from inpatients with diabetes mellitus were extracted. Calculations included patient-day weighted means (PDWMs) and percentage of patient hospital days with hypoglycemia. Results were overlaid onto hospital floor plans, and room numbers were used as geolocators to generate cross-sectional (2-dimensional) and perspective (3-dimensional) views of the data. Linear mixed and mixed-effects logistic regression models were used to compare the location effect and to assess statistical variation in the data after adjusting for age, sex, and severity of illness. Results: Visual inspection of cross-sectional and perspective maps demonstrated variation in glucometric outcomes across areas within the hospital. Statistical analysis confirmed significant variation between some hospital wings and floors. Conclusions: Spatial depiction of glucometric data within the hospital could yield insights into hot spots of poor glycemic control. Future studies on how to operationalize this approach, and whether this method of analysis can drive changes in glycemic management practices, need to be conducted.
The value of survival gains from therapeutic innovations for US patients with relapsed/refractory multiple myeloma
Authors: MacEwan Joanna P , Majer Istvan , Chou Jacquelyn W , Panjabi Sumeet 
Published: July 2021

Aims: This study quantifies the value of survival gains attributable to novel treatments approved since 2003 for United States (US) patients with relapsed/refractory multiple myeloma (RRMM). Methods: We estimated the increase in survival attributable to lenalidomide and bortezomib for multiple myeloma (MM) patients in the 1983–2013 Surveillance, Epidemiology, and End Results (SEER) registry. To estimate the survival benefit of treatments approved since 2015 (carfilzomib, elotuzomab, daratumumab, used in combination with lenalidomide and dexamethasone) we used clinical trial data to calibrate survival estimated using the SEER data. We then conducted an economic valuation of the estimated shift in survival curves for all therapies. Finally, we estimated the share of the value accruing to patients and manufacturers using treatment costs estimated from MarketScan data. Results: The introduction of bortezomib in combination with dexamethasone (Vd) and lenalidomide in combination with dexamethasone (Rd) resulted in substantial survival gains and societal value for multiple myeloma patients, generating 1.7 additional life-years per RRMM patient. More recently, approved novel treatments have improved survival over effective treatments (i.e. Rd/Vd) by an additional 2.5 life-years – the monetary value of this incremental survival benefit far exceeds the incremental cost of treatment. At the patient level, the incremental benefit of Rd/Vd is $335,500 and with novel treatments is $565,000. Applying this benefit to all future cohorts of US RRMM patients translates into a value of at least $75 billion and $130 billion with Rd/Vd and the novel treatments, respectively. Conclusions: SEER registry data were only available through 2013. Therefore, survival gains for recently approved treatments were estimated based on clinical trials, rather than observed survival. Our valuation analysis does not capture sources of value aside from survival gains, for example, better quality of life, increased productivity, or the value of surviving until subsequent novel therapies become available. Substantial extensions in life expectancy in RRMM since 2003 translate into real economic value gained by society.
Isolated Deep MCL tear: an easily missed injury and cause of persistent medial side knee pain
Authors: Gahlot Nitesh 
Published: July 2021

Introduction: The usual treatment of medial collateral ligament (MCL) grades I / II injuries is conservative, with good healing rates reported in the literature. Isolated deep MCL tears are reported rarely in literature, possibly due to under diagnosis. The usual reported mechanism is rapid external rotation of tibia at knee during sports. Methods: We report here 14 cases (all males, age range 21 - 35 years) of deep MCL tears with intact superficial MCL. All Patients were level 6 (recreational sports) on the Tegner- Lysholm activity scale. Diagnosis was done by grade 1 valgus stress test at 30-degree flexion, normal on 0 degrees. Confirmation was done by MRI imaging showing deep MCL fibers rupture on coronal T2 images. All of these patients had medial sided knee pain. Ten had associated knee injuries (10 had ACL tears, 5 had medial meniscus tears, 3 had lateral meniscus tears). Nine patients were diagnosed retrospectively on MRI due to symptom persistence; five were diagnosed preoperatively. Deep MCL repair was done in five patients. The dMCL was found to be avulsed from the femoral origin underneath an intact sMCL in all the cases. The repair was done over a suture anchor and was checked with intraoperative correction of the valgus stress test to normal. The Average follow-up duration was 10 months. Results: Five patients, diagnosed preoperatively, had medial sided knee pain resolution and no laxity complaints. The other nine patients reported slight pain on medial knee side at follow-up, for which local depomedrol and lignocaine injections were given under ultrasound guidance. The pain was resolved immediately and remains reduced at the time of last follow-up. The patient with repaired dMCL had better symptom resolution as compared to the patients managed with local steroid injections. Although there were no symptoms of laxity in any of the patients, even though the conservatively managed patients had valgus stress test grade 1 positive in 30 degree flexion, at the time of last follow-up. Conclusion: Isolated deep MCL tears are reported sparsely in literature. They can be a cause of persistent medial sided knee pain at follow-up, compromising the result of associated ligament reconstructions. The long-term outcomes of such injuries in terms of media laxity are not known, but a timely diagnosis can allow repair of the dMCL and better patient satisfaction.
The Effect of Bone Marrow Aspirate Concentrate on Clinical Results Used with Open Wedge High Tibial Osteotomy
Authors: Kaya Özgür , Uysal Özgür Selim , Emre Fahri , Kılıç Erden , Bozkurt Murat 
Published: July 2021

Objectives: Medial open wedge high tibial osteotomy is a widely used treatment method for early stages of medial compartment osteoarthritis, particularly in the middle aged patients. Correction of the malalignment of the knee and even distribution of the body weight through knee joint is considered to facilitate the regeneration of the damaged cartilage. Addition of a regenerative procedure to tibial osteotomies may enhance its potential effects. In this study we analyzed the effect of, if any, simultaneous use of BMAC with high tibial osteotomy. Methods: We have evaluated the clinical results of 46 knees of 38 patients that underwent open wedge high tibial osteotomy for early stage medial compartment arthrosis between 2017-2020. Patients were recruited into two groups as HTO only group (Group 1) and HTO+BMAC group (Group 2). Mean follow up time was 12.6 months. Preoperative International Knee Documentation Committee (IKDC) subjective score and Knee Society Score (KSS) of the patients were compared with those at the 1st, 3rd, 6th and 12th post-operative months. Wilcoxon Ranked Signed test was used to detect the significant difference. Results: Group 1 consisted of 18 female and 4 male patients, Group 2 consisted of 14 female and 2 male patients. Two patients in Group 1 received bilateral HTO and 6 patients in Group 2 received bilateral HTO+BMAC. Twenty four knees in Group 1 and 22 knees in Group 2 were included for evaluation. There was no significant improvement in the KSS and IKDC scores of the patients in Group 1 at the first follow-up, however at the 3rd month follow-up, KSS scores showed significant improvement (p<0,001) whereas IKDC scores did not show any improvement (p>0,005). Both KSS and IKDC scores showed significant improvement at the 6th and 12th months. (p<0,001). In Group 2, only KSS scores showed improvement at the 1st month follow-up (p<0,001). Both KSS and IKDC scores showed significant improvement at the 3rd, 6th and 12th month follow-up compared to preoperative scores. Conclusion: We believe that simultaneous use of BMAC with open wedge high tibial osteotomy for early stage medial compartment arthrosis may relieve pain at the early period and improve patient compliance to rehabilitation. Increase in range of motion promote the recovery period and provide rapid return to daily activities, thereby positively affecting cartilage regeneration.
Does measuring the medial gap before bone resection in total knee arthroplasty provide optimum gap adjustment and prevent bone recutting?
Authors: TİFtİkÇİ Uğur , Serbest Sancar , Tosun Hacı Bayram , Keskinkılıç Seyyid İsa , Kılınç Cem Yalın , Firat Ahmet 
Published: July 2021

Objectives: The aim of this study was to demonstrate that measuring the medial gap before bone resection during total knee arthroplasty (TKA) provides an optimum gap adjustment in varus knees. Methods: Patients were separated into two groups, Group 1 being those whose medial joint gap was measured prior to bone resection and Group 2 comprising those who underwent conventional measured resection technique without measuring. The medial joint gap was measured with a custom-made gap measuring device up to the point that the knee was corrected and aligned along its mechanical axis. Medial joint gap distances, distal medial femoral bone cut thicknesses, amounts of tibial resection calculated, gap internal distances measured after cutting, and the thicknesses of the trial inserts were recorded. A comparison was made between the groups in terms of the number of patients requiring an additional tibial bone cut and the distribution of insert thicknesses. Results: Extra tibial bone resections performed in two (5.7%) patients in Group 1 and in 10 (28.6%) patients in Group 2. In Group 1, where the medial joint gap was measured, the need for an additional bone resection was statistically less. (p=0.018). In the comparison of distribution of insert size by group, the number of patients on whom an 8 mm insert had been used was significantly greater in Group 1 (p=0.024). Conclusion: Measuring the medial joint gap prior to bone resection in total knee arthroplasty may prevent repeated bone recutting and additional bone resections. Furthermore, we can use this method to avoid the disadvantages of the measured resection technique.
All-inside reconstruction of anterior cruciate ligament with single-bundle autogenous peroneal longus tendon
Authors: Lanbo Yang , Chunyu Zou , Yufei Mi , Zhanchao Wang 
Published: July 2021

Objectives: To evaluate the curative effect of all-inside reconstruction of anterior cruciate ligament with single-bundle autogenous peroneal longus tendon. Methods: A total of 21 people who met the including criteria were enrolled into this study. The autogenous peroneal longus tendon were got to all-inside anterior cruciate ligament reconstruction. The complications were documented, while the clinical consequences was evaluated by Lachman test, KOOS, SF - 36 and AOFAS. Results: There were no serious complications after operation. Lachman test showed that the stability of knee joint after operation was significantly improved (P < 0.05). The KOOS score significantly improved at 12 months postoperatively, including pain, symptoms, activity of daily living, sport and recreation function and knee related quality of life, compared with those before operation (P<0.05). In addition, the SF-36 score also significantly improved at 12 months postoperatively compared with those preoperatively, with statistically significant differences in physical functioning, physical role functioning, bodily pain, general health perceptions, emotional role functioning and social role functioning (P<0.05), whereas no statistically significant differences in vitality and mental health (P>0.05). Conclusion: The all-inside reconstruction of anterior cruciate ligament with single-bundle peroneal longus tendon can effectively restore the stability of knee joint, reduce postoperative pain, improve the function of knee joint, and provide high satisfaction.
Remission of Recalcitrant Psoriasis on Combined Biologic Therapy With Infliximab and Ustekinumab
Authors: Taylor Kayla H. , Feldman Steven R. 
Published: July 2021

Introduction: Anti-TNF treatment is effective for inflammatory bowel disease (IBD), however it also has the potential to cause paradoxical psoriasis which can be challenging to manage. Discontinuation of anti-TNF agents may improve psoriatic lesions but may worsen IBD. Combining biologic therapies, though not yet commonly practiced, may be a useful approach to the treatment of both conditions. Case Presentation: We describe a case of paradoxical palmoplantar psoriasis in a 48-year-old woman with ulcerative colitis (UC). Her UC was well-managed on infliximab. Following trials of several other topical and systemic therapies for her psoriatic lesions, she ultimately received relief on combined ustekinumab and infliximab therapy without flare of her IBD. Discussion: While other publications report success using ustekinumab for paradoxical psoriasis following cessation of infliximab, this case report highlights successful treatment using a combination of ustekinumab and infliximab with no reported adverse effects at 3 months. Conclusion: Discontinuation of the anti-TNF agent and use of a single biologic that may treat both IBD and psoriasis is a treatment option. Additionally, combining biologic therapies, though not yet commonly practiced, may be a useful, albeit costly, approach to prevent potential flares of IBD that may accompany cessation of some biologics. Further studies may be beneficial to assess for long term adverse effects.