bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spiritual Care Experiences of Nurses Working in Gynecology Clinic: A Qualitative Research
Authors: Başaran Fatma , Şahin Merve , Salık Hava 
Published: February 2025

ABSTRACTRationalePregnancy and childbirth are among the most important events in a woman's reproductive life. In this process with full of uncertainties, nurses who provide primary care to women play a key role. Spiritual care is an important part of holistic care and an indicator of quality of care.AimThis research aims to thoroughly examine and describe the spiritual care experiences of nurses working in obstetrics and gynecology clinics specific to their clinics.MethodsThe study was carried out based on the descriptive phenomenology type of phenomenology design, one of the qualitative research methods. The study group included nurses in gynecology clinics in different provinces and hospitals in Turkey. The criterion sampling method, one of the purposive sampling methods, was used, and 12 nurses comprised the sample size. A semi‐structured interview form was used to collect the data. In evaluating the obtained data, thematic content analysis and MAXQDA 22 software were used. The study was written based on the COREQ checklist.ResultsThe data obtained from the interviews were analyzed under six themes: the concept of spiritual care, spiritual care practices, factors complicating spiritual care, factors facilitating spiritual care, emotional effects of spiritual care, and recommendations on the best way to provide spiritual care.ConclusionsIt is vital to train gynecology nurses in spiritual care, reduce their workload, and develop clinical practice guidelines. Increasing the awareness of obstetric nurses about the factors affecting their spiritual care experiences while caring for individuals in clinical practices will contribute to increasing the quality of nursing care.
Optimal Flood Discharge Scheduling to Alleviate Vibration Under Gate Operational Rules
Authors: Yang Zetai , Feng Suzhen , Fu Kaixiang , Wang Jinwen 
Published: February 2025

ABSTRACTThe concomitant vibration of flood discharge, which would cause structure damages to hydraulic infrastructure and thus incurs threats to nearby communities, has rarely been addressed yet cries for an effective solution in discharge scheduling of sluice gates. This work improves on the traditional practice (Model‐I) that mainly aims to restrain start‐up and shutdown actions of spillway gates with a new model (Model‐II) that includes a flexible vibration damping rule, in which the sluice gates are grouped in priority to be sequentially committed, and in the same group, a reference gate is prioritised to enforce a uniform discharge from the active outlets and the gates are paired to ensure a symmetrical opening. The case studies in the Xiangjiaba Dam (XD) demonstrate the excellent adaptability of the model to gate opening patterns concluded with field experiments and site monitoring, and comparing the two models reveals that Model‐II can enforce preferable operational rules to deliver safer discharge scheduling and potentially to reduce risks from the concomitant vibration of hydraulic facilities and the turbulent flow field around the dam during flood discharging, though leading to a much higher frequency of starting up and shutting down of sluice gates than the traditional Model‐I.
Intersectionality
Authors: Echeverria Alejandro 
Published: February 2025

AbstractIn this piece, I explore the “pretty word” of intersectionality to contribute to existing discussions on its usage as an analytical framework and tool among social justice projects. Through my personal queer journey in podcasting, the coming‐out experience, and traversing across various spaces, I highlight the importance of incorporating a relational, embodied, and geographic perspective within intersectionality. I reveal how this perspective can unsettle common assumptions about social identities, specifically a fixed view of racialized‐sexualized identities and the location of oppressions and privileges. Through various situations, movements, and reflections, I uncover an emerging approach to intersectionality that exists in relation to different spatialities and temporalities rather than in isolation. I reveal the limits of common applications of intersectionality in health equity research while also recognizing the pitfalls that some institutions and social actors fall into while promoting diversity, equity, and inclusion, including the reproduction of common ideas of victimhood and superiority. Ultimately, this article advocates for building new worlds by reworking the ways researchers and communities connect and relate with one another and themselves.
Severity of Chronic Kidney Disease as Assessed by the Kidney Failure Risk Equation Is Associated With Incident Acute Ischemic Stroke
Authors: Tan Benjamin Y. Q. , Tan Yong Yi , Lim Sean Shi‐An , Toh Emma M. S. , Tack Reinier W. , Lim Pamela W. N. , Kumari Shikha , Koh Sky W. C. , Khatri Priyanka , Rastogi Shilpa , Yeo Leonard L. L. , Anderson Christopher D. , Chua Horng‐Ruey , Chua Yan Ting , Ngoh Clara L. Y. 
Published: February 2025

ABSTRACTAimStroke is a leading cause of death and disability, with substantial healthcare implications. Chronic kidney disease (CKD) is similarly impactful, and emerging evidence links CKD to a higher stroke risk. Despite this, stroke risk assessment in CKD patients remains limited. This study explores the kidney failure risk equation (KFRE) as a predictive tool for ischaemic stroke in CKD patients.MethodsThis retrospective cohort study analysed CKD patients from a healthcare registry, excluding those with prior stroke, end‐stage kidney disease, or kidney transplants. Acute ischemic stroke was the primary outcome, with deaths censored. Cox proportional hazards models evaluated associations between the 2‐year and 5‐year 4‐variable KFRE scores and stroke risk.ResultsA total of 14,794 consecutive patients were included, with a median follow‐up of 509 days. The median age of the cohort was 73 years (IQR:14 years), with 6251 females(42.3%), and the majority being of Chinese ethnicity (n = 10 759,73.5%). During the follow‐up period, 155 patients (1.05%) experienced an ischemic stroke event, with a median time to stroke of 265 days (IQR:242 days). The 2‐year (HR: 1.38 per 10% increase, 95% CI: [1.17–1.63], p < 0.001) and 5‐year (HR:1.20 per 10% increase, 95% CI: [1.10–1.31], p < 0.001) 4‐variable KFRE scores were significantly associated with an increased risk of ischemic stroke. These associations remained significant after adjusting for patient demographics, comorbidities, advanced CKD stage, glycated haemoglobin and lipid parameters.ConclusionCKD patients at elevated risk of kidney failure also face a significantly increased risk of acute ischaemic stroke. The KFRE could potentially be integrated into CKD management to assess this risk. Future large prospective cohort studies are necessary to validate these findings.
Nur77 Promotes Inflammation in Cisplatin‐Induced Acute Kidney Injury Through Transactivation of SERPINA3 Mediating Wnt/β‐Catenin Pathway
Authors: Zhou Ying , Wan Zhen , Xiong Di , Gong Zhijun , Liu Feiyan 
Published: February 2025

ABSTRACTAimAcute kidney injury (AKI) is the most common complication in the treatment of cisplatin, which is a clinically effective and classical anticancer drug. Orphan Nuclear Receptor Nur77 has been found to promote renal ischaemia–reperfusion injury. In this study, we aim to explore the effects of Nur77 on cisplatin‐induced AKI (CI‐AKI) and its underlying mechanism.MethodsHK‐2 cells treated with cisplatin were used to construct the CI‐AKI model in vitro. Cell viability and cell proliferation were analysed using CCK‐8 and EdU assays, respectively. Cell apoptosis was analysed by flow cytometry. The inflammation release level was detected using ELISA. Molecular abundance was evaluated using qPCR, Western blot and immunofluorescence. The interaction between Nur77 and SERPINA3 was clarified using ChIP and dual‐luciferase reporter gene assays.ResultsOur works demonstrated that Nur77 and SERPINA3 expression were considerably ascended in cisplatin‐induced HK‐2 cells. The silence of SERPINA3 alleviated cisplatin‐stimulated HK‐2 cell injury, which was characterised by increased cell viability and proliferation, and decreased apoptosis and inflammatory cytokine release. In addition, Nur77 promotes SERPINA3 transcription by binding to the SERPINA3 promoter region (−182 to −175), thereby upregulating SERPINA3 expression and activating the Wnt/β‐catenin pathway. Moreover, HK‐2 cell injury induced by cisplatin was notably inhibited by the knockdown of Nur77. Furthermore, the efficacy of Nur77 downregulation on the cell injury in cisplatin‐stimulated HK‐2 cells was antagonised by SERPINA3 overexpression.ConclusionTaken together, our findings revealed that Nur77 knockdown resisted cisplatin‐induced HK‐2 cells injury through lessening the expression of SERPINA3 mediated by transcriptional regulation and inactivating the Wnt/β‐catenin pathway.
Ecosystem engineers alter the evolution of seed size by impacting fertility and the understory light environment
Authors: Doughty Christopher E. , Wiebe Benjamin C. , Keany Jenna M. , Gaillard Camille , Abraham Andrew J. , Kristensen Jeppe A. 
Published: February 2025

AbstractIt has been hypothesized that the extinction of the dinosaurs, and later the Pleistocene megafauna, created a darker forest subcanopy benefiting large‐seeded plants. Larger seeds and their fruit, in turn, opened a dietary niche space for animals thus strongly shaping the ecology of the Cenozoic, including our fruit‐eating primate ancestors. In this paper, we develop a mechanistic model where we replicate the conditions of tropical forests of the early Paleocene, with small animal body and small seed size, and the Holocene, with small animal body and large seed size. We first calibrate light levels in our model using stable carbon isotope ratios from fossil leaves and estimate a decrease of understory light of c. 90 μmol m−2 s−1 (a 19% decrease) from the Cretaceous to the Paleocene. Our model predicts a rapid increase in seed size during the Paleocene that eventually plateaued or declined slightly. Specifically, we find a dynamic feedback where increased animal sizes opened the understory causing negative feedback by increasing subcanopy light penetration that limited maximum seed size, matching the actual trend in angiosperm seed sizes in mid/high latitude ecosystems. Adding the ability of larger animals to increase ecosystem fertility to the model, further increased mean animal body size by 17% and mean seed size by 90%. Our model is a drastic simplification and there are many remaining uncertainties, but we show that ecological dynamics can explain seed size trends without adding external factors such as climate change.
A New Allele HLA‐DRB4*01:03:01:22 Identified by HLA‐Targeted Third‐Generation Sequencing
Authors: Zhao Yuanli , Fan Wu , Yang Song , Gao Peng , Wang Liying 
Published: February 2025

ABSTRACTHLA‐DRB4*01:03:01:22 differs from HLA‐DRB4*01:03:01:06 by one nucleotide change in intron 2.
Characterisation of the Novel HLA‐DQB1*05:355 Allele by Sequencing‐Based Typing
Authors: Pajot Thibault , Elsermans Vincent , Top Isabelle , Labalette Myriam 
Published: February 2025

ABSTRACTHLA‐DQB1*05:355 differs from HLA‐DQB1*05:01:01:01 by one nucleotide substitution in codon 197 in exon 4.
Characterisation of the Novel HLA‐A*02:1198 Allele by Sequencing‐Based Typing
Authors: Pajot Thibault , Elsermans Vincent , Top Isabelle , Labalette Myriam 
Published: February 2025

ABSTRACTHLA‐A*02:1198 differs from HLA‐A*02:01:01:01 by one nucleotide substitution in codon −22 in exon 1.
Characterisation of the Novel HLA‐C*05:01:83 Allele by Sequencing‐Based Typing
Authors: Pajot Thibault , Elsermans Vincent , Top Isabelle , Labalette Myriam 
Published: February 2025

ABSTRACTHLA‐C*05:01:83 differs from HLA‐C*05:01:01:01 by one nucleotide substitution in codon 291 in exon 5.
Red blood cell inventory management: Insights from transfusion laboratory technologists in British Columbia, Canada
Authors: Dhahan Jasdeep , Morrison Douglas , Shih Andrew W. , McDonald Deb , Chen Robby , Hao Lillian , Rosinski Kristin , Buchko Sarah , Blake John , Rutherford Alexander 
Published: February 2025

AbstractBackground and ObjectivesThere is concern about sustaining the O negative blood supply, especially in areas with many rural/remote hospitals like British Columbia. Red blood cells are perishable, making inventory management challenging. Demand must be met without wasting this precious resource. Inventory management challenges stem from data scarcity and human factors. Transfusion medicine technologists, who manage inventory daily, are key to understanding the human factors in inventory management. We conducted a qualitative study to understand technologists' inventory management perspectives and experiences, particularly for group O negative red blood cells, aiming to inform future inventory modelling to address human factors.Materials and MethodsWe interviewed transfusion laboratory technologists and technical leads from all health authorities and a blood product supplier representative for the Province of British Columbia. Thematic analysis of the interview transcripts was conducted.ResultsWe found five themes that influence technologist decision‐making on RBC inventory management, key challenges for O‐negative RBCs, and identified inventory management strategies. We compare the top three inventory practices from our results with literature.ConclusionsOur findings help bridge the knowledge gap concerning human factors in RBC inventory management, with potential generalizability to other jurisdictions. They hold promise for informing the safeguarding of donors' altruistic contributions.
Evaluation of Complement‐Dependent Cytotoxicity Assays for Gene‐Edited Pig‐to‐Human Xenotransplantation
Authors: Feng Hao , Zhang Man , Xia Qiangbing , Du Jiaxiang , Li Tao , Chen Song , Wang Yi , Pan Dengke , Zhu Lan , Chen Gang 
Published: February 2025

ABSTRACTBackgroundGene‐edited pigs for xenotransplantation usually contain one or more transgenes encoding human complement regulatory proteins (CRPs). Because of species differences, human CRP(s) expressed in gene‐edited pigs may have difficulty inhibiting the activation of exogenous rabbit complement added to a complement‐dependent cytotoxicity (CDC) assay. The use of human complement instead of rabbit complement in CDC experiments may more accurately reflect the actual regulatory activity of human CRP(s).MethodsPeripheral blood mononuclear cells (PBMCs) were obtained from one GTKO pig and two GTKO/hCD55 pigs with a high or low level of hCD55 expression. After incubation of heat‐inactivated normal human sera (HINHS) with porcine PBMCs, CDC levels were measured after the addition of commercial rabbit complement or human complement. In addition, a modified one‐step CDC method was established using pooled normal human sera (NHS) without the addition of an exogenous complement.ResultsThere was no significant difference in the binding of IgM/IgG to PBMCs from the three pigs. Both rabbit and human complement‐mediated a significant cytotoxic effect on GTKO pig PBMCs (98.97% vs. 82.73%). Even the high expression of hCD55 only had a very limited inhibitory effect on rabbit complement‐mediated cytotoxicity (81.70% vs. 98.97%). However, regardless of whether the expression level was high or low, hCD55 had a very remarkable inhibitory effect on human complement‐mediated cytotoxicity (2.94% and 23.83% vs. 82.73%; p < 0.01). Similar results were obtained using the modified one‐step CDC method. In addition, the inhibitory effect of hCD55 on C3c and C5b‐9 deposition on pig PBMCs was positively correlated with the expression level of hCD55.ConclusionThe use of human complement instead of rabbit complement in CDC assays can better reflect the actual cytotoxic effect of human xenoantibodies against pig PBMCs expressing human CRP(s), and thus may have potential application to gene‐edited pig‐to‐human xenotransplantation.
Sideband Peak Count Technique for Monitoring Bond–Slip Behavior Between Reinforcement Systems and Masonry
Authors: Castellano Anna , Pinchuk Nataliia , Fraddosio Aguinaldo , Martellotta Gianfranco , Piccioni Mario Daniele , Kundu Tribikram 
Published: February 2025

Abstract
The use of Fabric-Reinforced Cementitious Matrix (FRCM) composites has become a cornerstone in strengthening several types of structures, ranging from reinforced concrete structures to historical masonry constructions. It is crucial to experimentally assess the effectiveness of the application of the reinforcing layer. Indeed, the performance of FRCM reinforcing interventions highly depends on the bonding at the matrix–fiber and matrix–substrate interfaces. Therefore, the experimental characterization of FRCM bond behavior is essential for designing and ensuring the durability of reinforcement systems. To address this, we have proposed using an innovative nonlinear ultrasonic method: the Side-band Peak Count (SPC) technique. Specifically, the SPC approach has been applied to analyze ultrasonic test results obtained during Double-Lap Shear Tests (DLT) conducted on masonry specimens reinforced with B-FRCM (basalt fiber textile FRCM). We show that it is possible to correlate nonlinear ultrasonic parameters with the shear stress distribution at the reinforcement–masonry interface. Additionally, a relatively new nonlinear ultrasonic parameter, the SPC index, is shown to be effective in monitoring the evolution of the shear stress–slip relationship at this interface, a crucial aspect for understanding the mechanics of the reinforcement–substrate interaction. The nonlinear ultrasonic results have been compared with the results of DLT debonding tests to validate the proposed methodology. The effectiveness of the SPC technique is investigated and discussed. Finally, we have developed a robust numerical model to analyze the bond behavior between the reinforcement and masonry. The numerical model is valuable for both the design of experimental tests and the validation of the experimental results.
Torsional Vibration of Drill String Induced by Heave Motion in Deepwater Drilling
Authors: Kaneko Tatsuya , Inoue Tomoya , Wada Ryota , Katsui Tokihiro , Hiroyoshi Suzuki 
Published: February 2025

Abstract
Understanding drill-string dynamics is essential to improving drilling efficiency and preventing accidents. Previous studies have mainly focused on self-excited oscillations due to stick-slip and bit-bounce. However, in deepwater drilling, large weight-on-bit fluctuations due to heave motion are a significant concern that can affect torsional dynamics. This paper reports analytical, numerical, and field data investigations on torsional vibrations of a drill string in deepwater drilling. First, we analyzed the field data from deep-sea scientific drilling vessel Chikyu. The field data showed that heave, WOB, and torque oscillated at similar frequencies. This result indicated that the drill string could have forced torsional vibrations due to heave instead of self-excited vibrations due to stick-slip.Second, we analytically and numerically investigated drill-string torsional dynamics. The torsional vibration of the drill string can be described only by self-excited vibration due to stick-slip if WOB is constant. However, when the WOB fluctuates, the forced vibration of the WOB must be considered. The results showed that vibration at the heave frequency had a more significant effect on torsional vibration than the axial self-excited frequency for the same amplitude of WOB variation. In addition, large WOB fluctuations increased the risk of stick-slip and reverse rotation of the drill bit. Numerical experiments with the field data showed that the forced torsional vibration caused by heave motion was predominant in deepwater drilling. These results show the importance of capturing forced torsional vibrations and reducing WOB fluctuations.
Wire Arc Additive Manufacturing With Infrared Image Feedback
Authors: He Honglu , Wen John T. 
Published: February 2025

Abstract
Wire arc additive manufacturing (WAAM) is a metal 3D printing technology that rapidly prototypes by depositing molten metal wire onto a substrate. Traditionally, WAAM has relied on the open-loop control with carefully tuned parameters, a process that can be time-consuming and often results in inconsistent performance. Although laser line scanners and other 3D scanning techniques have been used to ensure geometric fidelity, they typically provide feedback through layer-by-layer scans, leaving imperfections from arc striking and extinguishing. This paper introduces a novel approach that incorporates infrared (IR) camera thermography to achieve more consistent and reliable WAAM printing with real-time feedback. By using IR live streaming to close the loop with in-layer updates, we demonstrate how this feedback mechanism can enhance control over bead width consistency and wire stick-out length, ultimately leading to higher-quality metal 3D-printed structures. Compared with open-loop preset constant welding parameters on a triangular wall geometry, our IR-guided WAAM process achieves 49% bead width variance reduction and 95% wire stick-out length tracking improvement.
Mixed-methods study to develop extensions to the SPIRIT and CONSORT statements for factorial randomised trials: the Reporting Factorial Trials (RAFT) study
Authors: Hall Sophie S , Juszczak Edmund , Birchenall Megan , Elbourne Diana , Beller Elaine , Chan An-Wen , Little Paul , Montgomery Alan A , Kahan Brennan C 
Published: February 2025

BackgroundExtensions to Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) and Consolidated Standards of Reporting Trials (CONSORT) reporting recommendations specifically for factorial trials have been developed by the Reporting Factorial Trials (RAFT) study group. This article describes the processes and methods used to develop the extensions.ObjectiveTo develop SPIRIT and CONSORT extensions for factorial trials.Design and participantsA four-phase, consensus-based approach was used: phase 1: scoping review, phase 2: Delphi survey (n=104 respondents in round 1), phase 3: consensus meeting (n=15 members) and phase 4: checklist finalisation.ResultsIn phase 1, the scoping review identified 31 reporting recommendations, which formed a long list of 50 concepts (19 applied to the SPIRIT extension and 31 applied to the CONSORT extension) to include in the guideline development. In phase 2, a three-round Delphi survey resulted in two new concepts being added and ended with 49 concepts (19 applied to SPIRIT and 30 applied to CONSORT) reaching consensus to remain, with only three concepts meeting the exclusion criteria. In phase 3, the concepts were further refined and translated into specific extension item wording, through an extensive review process conducted by the core RAFT team and leading trial experts, who attended a 2-day hybrid meeting. The resulting 9 SPIRIT items and 17 CONSORT items were further evaluated and developed through an iterative process in phase 4, to promote user acceptance and uptake.ConclusionUptake of the CONSORT and SPIRIT extensions will improve the conduct of factorial trials, as well as understanding and interpretation of such trials. By reporting on how these extensions were developed, we promote transparency of this process and share learning experiences to develop best practice when developing reporting guidelines.