bluuebunny/crossref_metadata_2025_split huggingface dataset:
SELECTIVE MEMORY: MONUMENTAL POLITICS OF THE YAXUNÁ E GROUP IN THE FIRST MILLENNIUM B.C.
Authors: Collins Ryan H. 
Published: August 2021

AbstractIn seeking continuities and disjuncture from the precedents of past authorities, the Mesoamerican emergent ruling class during the Formative period were active agents in directing changes to monumental space, suggesting that memory played a vital role in developing an early shared character of Maya lifeways (1000b.c.toa.d.250). The trend is most visible in the civic ceremonial complexes known as E Groups, which tend to show significant patterns of continuity (remembering) and disjuncture (forgetting). This article uses the northern lowland site of Yaxuná in Yucatan, Mexico, to demonstrate the use of early selective strategies to direct collective memory. While there are E Groups in the northern Maya lowlands, few Formative period examples are known, making Yaxuná a critical case study for comparative assessment with the southern lowlands. One implication of the Yaxuná data is that the broader pattern of Middle Formative E Groups resulted from sustained social, religious, political, and economic interaction between diverse peer groups across eastern Mesoamerica. With the emergence of institutionalized rulership in the Maya lowlands during the Late Formative, local authorities played a significant role in directing transformations of E Groups, selectively influencing their meanings and increasingly independent trajectories through continuity and disjuncture.
Cardiac responses in paediatric Pompe disease in the ADVANCE patient cohort
Authors: Byrne Barry J. , Colan Steven D. , Kishnani Priya S. , Foster Meredith C. , Sparks Susan E. , Gibson James B. , An Haack Kristina , Stockton David W. , Peña Loren D. M. , Hahn Si Houn , Johnson Judith , Tanpaiboon Pranoot X. , Leslie Nancy D. , Kronn David , Hillman Richard E. , Wang Raymond Y. 
Published: August 2021

AbstractPompe disease results from lysosomal acid α-glucosidase deficiency, which leads to cardiomyopathy in all infantile-onset and occasional late-onset patients. Cardiac assessment is important for its diagnosis and management. This article presents unpublished cardiac findings, concomitant medications, and cardiac efficacy and safety outcomes from the ADVANCE study; trajectories of patients with abnormal left ventricular mass z score at enrolment; and post hoc analyses of on-treatment left ventricular mass and systolic blood pressure z scores by disease phenotype,GAAgenotype, and “fraction of life” (defined as the fraction of life on pre-study 160 L production-scale alglucosidase alfa). ADVANCE evaluated 52 weeks’ treatment with 4000 L production-scale alglucosidase alfa in ≥1-year-old United States of America patients with Pompe disease previously receiving 160 L production-scale alglucosidase alfa. M-mode echocardiography and 12-lead electrocardiography were performed at enrolment and Week 52. Sixty-seven patients had complete left ventricular mass z scores, decreasing at Week 52 (infantile-onset patients, change −0.8 ± 1.83; 95% confidence interval −1.3 to −0.2; all patients, change −0.5 ± 1.71; 95% confidence interval −1.0 to −0.1). Patients with “fraction of life” <0.79 had left ventricular mass z score decreasing (enrolment: +0.1 ± 3.0; Week 52: −1.1 ± 2.0); those with “fraction of life” ≥0.79 remained stable (enrolment: −0.9 ± 1.5; Week 52: −0.9 ± 1.4). Systolic blood pressure z scores were stable from enrolment to Week 52, and no cohort developed systemic hypertension. Eight patients had Wolff–Parkinson–White syndrome. Cardiac hypertrophy and dysrhythmia in ADVANCE patients at or before enrolment were typical of Pompe disease. Four-thousand L alglucosidase alfa therapy maintained fractional shortening, left ventricular posterior and septal end-diastolic thicknesses, and improved left ventricular mass z score.Trial registry:ClinicalTrials.gov Identifier: NCT01526785https://clinicaltrials.gov/ct2/show/NCT01526785.Social Media Statement:Post hoc analyses of the ADVANCE study cohort of 113 children support ongoing cardiac monitoring and concomitant management of children with Pompe disease on long-term alglucosidase alfa to functionally improve cardiomyopathy and/or dysrhythmia.
The Party-Line Pandemic: A Closer Look at the Partisan Response to COVID-19
Authors: Camobreco John F. , He Zhaochen 
Published: August 2021

ABSTRACTThe response to the coronavirus pandemic in the United States has shown that even a serious public health crisis cannot escape the lens of partisanship. The literature shows that most Republicans have viewed the coronavirus as less serious than their Democratic counterparts. This study demonstrates that this partisan gap extends to the real behavior of the public during, and after, the coronavirus state lockdowns. Using location data from mobile phones, we find that county-level partisanship predicts compliance with state shutdown orders, even when controlling for local COVID-19 intensity. Further, the magnitude of this effect is stronger than that of other explanatory variables, such as age, education, and population density. These results show that partisan beliefs can affect behavior regarding issues that are not overtly political, even behaviors that could put one or others at risk.
Inflammation, cognitive dysfunction, and suicidal ideation among patients with major depression
Authors: Huang Mao-Hsuan , Chen Mu-Hong , Hsu Ju-Wei , Huang Kai-Lin , Tsai Shih-Jen , Su Tung-Ping , Bai Ya-Mei 
Published: August 2021

AbstractBackgroundDysregulated proinflammatory cytokines have been shown to be associated with suicidal behavior. Cognitive deficits in working memory and inhibitory control have been demonstrated in depressed patients and people with suicidal ideation (SI). However, the association between proinflammatory cytokines, SI, and cognitive deficits in patients with major depressive disorder (MDD) remains unclear.MethodsA total of 77 patients with MDD and age-/sex-matched 60 healthy individuals were recruited. MDD patients were divided into two groups: with SI (n = 36) and no SI (n = 41). SI was defined by a score of ≥2 in item 3 of the 17-item Hamilton Rating Scale for Depression. Levels of proinflammatory cytokines, including soluble interleukin-6 receptor, soluble tumor necrosis factor-α receptor type 1, and C-reactive protein (CRP), were measured, and cognitive function was assessed using 2-back task and Go/No-Go task.ResultsPatients with SI had higher levels of CRP than those without SI and controls (P = .007). CRP was positively associated with SI (β = 0.21, P = .037), independent of cognitive function and depressive symptoms. Furthermore, SI was associated with cognitive deficits in working memory and inhibitory control after adjusting for confounding factors (P < .05).ConclusionOur findings suggest that higher levels of serum CRP and deficits in working memory and inhibitory control may be associated with higher SI among patients with MDD.
The role of education and migration background in explaining differences in folic acid supplementation intake in pregnancy: results from a German birth cohort study
Authors: Miani Céline , Ludwig Angelique , Doyle Ina-Merle , Breckenkamp Jürgen , Hoeller-Holtrichter Chantal , Spallek Jacob , Razum Oliver 
Published: August 2021

AbstractObjective:Official German recommendations advise women to start taking folic acid supplementation (FAS) before conception and continue during the first pregnancy trimester to lower the risk of birth defects. Women from lower socio-economic background and ethnic minorities tend to be less likely to take FAS in other European countries. As little is known about the determinants of FAS in Germany, we aimed to investigate the association between FAS and formal education and migration background, adjusting for demographic factors.Design:We used data (2013–2016) on nutrition and socio-economic and migration background from the baseline questionnaire of the BaBi cohort study. We performed multivariate regressions and mediation analyses.Setting:Bielefeld, Germany.Participants:Nine-hundred forty-seven women (pregnant or who had given birth in the past 2 months).Results:16.7% of the participants (158/947) did not use FAS. Migration-related variables (e.g. language, length of stay) were not associated with FAS in the adjusted models. FAS was lower in women with lower level of formal education and in unplanned pregnancies. Reasons given by women for not taking FAS were unplanned pregnancy and lack of knowledge of FAS.Conclusions:Health practitioners may be inclined to see migrant women as an inherently at-risk group for failed intake of FAS. However, it is primarily women who did not plan their pregnancy, and women of lower formal education level, who are at risk. Different public health strategies to counter low supplementation rates should be supported, those addressing the social determinants of health (i.e. education) and those more focused on family planning.
PRICING TIMER OPTIONS: SECOND-ORDER MULTISCALE STOCHASTIC VOLATILITY ASYMPTOTICS
Authors: WANG XUHUI , WU SHENG-JHIH , YUE XINGYE 
Published: August 2021

AbstractWe study the pricing of timer options in a class of stochastic volatility models, where the volatility is driven by two diffusions—one fast mean-reverting and the other slowly varying. Employing singular and regular perturbation techniques, full second-order asymptotics of the option price are established. In addition, we investigate an implied volatility in terms of effective maturity for the timer options, and derive its second-order expansion based on our pricing asymptotics. A numerical experiment shows that the price approximation formula has a high level of accuracy, and the implied volatility in terms of its effective maturity is illustrated.
The Opportunities of Working in a Challenging Environment
Authors: Muluneh Ameha Atnafu 
Published: August 2021

AbstractA few days after the American Geophysical Union announced that I am the recipient of the 2020 Africa Award for research excellence in Earth or Ocean Sciences, I received an email from Michael Wysession, editor‐in‐chief of Perspectives of Earth and Space Scientists, to write a story about my scientific experiences. I was filled with emotions. I never thought of sharing my experience with other people (except to my wife and children and close friends). I hope my story will inspire mainly marginal students, who may think that society will exclude them owing to western credentials, and believe that they cannot achieve a spot in science because of their grades. I strongly believe that scientific excellence is achieved by hard work (mostly in a subject area that you like), and a little bit of good luck.
Thallium Isotopic Compositions in Hawaiian Lavas: Evidence for Recycled Materials on the Kea Side of the Hawaiian Mantle Plume
Authors: Williamson Nicole M. B. , Weis Dominique , Prytulak Julie 
Published: August 2021

AbstractHawaiian volcanoes record 6 Ma of potentially deep mantle chemistry and form two parallel volcanic chains that are geochemically unique, named Loa and Kea. Loa volcanoes erupt lavas with isotopically enriched compositions thought to reflect the presence of recycled material in the deep mantle source of the Hawaiian plume. Variations in stable thallium (Tl) isotopes have been used to trace recycled pelagic ocean sediment from subduction to eruption in arc and intraplate lavas. Previous work attributed heavy Tl isotopic compositions in eight Loa samples to recycled sediments in their source. We reexamined this hypothesis using a large sample set (n = 34) of shield‐stage, tholeiitic basalt from 13 Hawaiian volcanoes representing the entire range of isotopically enriched and depleted compositions along the Hawaiian chain. Samples were acid‐leached prior to isotopic analysis to remove post‐eruption alteration and resulting ε205Tl values show statistical differences between Loa and Kea volcanoes. Corresponding isotopic data and re‐analyzed trace element concentrations suggest that the ε205Tl values are primary magmatic signatures. Possible co‐variations between heavy ε205Tl and oxygen isotopes in samples from Kea‐trend volcanoes could reflect the presence of ancient, recycled pelagic sediment on the Kea side of the Hawaiian plume, which samples the average deep Pacific mantle. As such, the deep mantle source of both Loa and Kea Hawaiian volcanoes may contain recycled materials of different natures and recycling histories, which supports work from both geophysical and geochemical studies suggesting that the Earth's lower mantle is chemically heterogeneous on multiple spatial scales.
The Transport History of Alluvial Fan Sediment Inferred From Multiple Geochronometers
Authors: Goehring Brent M. , Brown Nathan , Moon Seulgi , Blisniuk Kimberly 
Published: August 2021

AbstractWe present a multi‐chronometer approach to refine the age of an alluvial fan and to infer sediment transport and deposition history in the Anza Borrego Desert region of Southern California. We measure in situ produced cosmogenic carbon‐14 (14C) from boulders on the fan surface and infrared stimulated luminescence (IRSL) ages from single feldspar grains within the alluvium. Our new IRSL age [5.3 ± 0.5 ka (±1σ)] is in excellent agreement with existing uranium‐series [U‐series; 5.3 ± 0.2 (±2σ)] ages of pedogenic carbonates. The IRSL and U‐series ages show that in situ 14C measurements [6.6 ± 1.1 ka (±1σ)] from boulders contain inherited nuclides from prior exposure in the upstream catchment, much like measurements of the longer‐lived nuclide, beryllium‐10 (10Be). However, in situ 14C ages are closer to the preferred ages inferred from IRSL and U‐series and with less scatter than comparative 10Be ages. Our data demonstrate that a multi‐geochronometer approach will produce ages of alluvial fan surfaces with the greatest degree of confidence. We then apply the paired 14C and 10Be concentrations to infer the prior exposure and storage duration of the sampled boulders of 3.1 ± 3.2 and 4.6 ± 2.3 Kyr, respectively. A mixture model analysis of the single grain IRSL ages suggests bimodal storage durations prior to remobilization with peaks at ca. 2 and 10 Kyr. We demonstrate that cosmogenic nuclide inheritance and single grain IRSL equivalent dose distributions can provide additional information regarding sediment transport history prior to deposition on the alluvial fan.
Controls on Water Storage and Drainage in Crevasses on the Greenland Ice Sheet
Authors: Chudley T. R. , Christoffersen P. , Doyle S. H. , Dowling T. P. F. , Law R. , Schoonman C. M. , Bougamont M. , Hubbard B. 
Published: August 2021

AbstractSurface crevasses on the Greenland Ice Sheet (GrIS) capture nearly half of the seasonal runoff, yet their role in transferring meltwater to the bed has received little attention relative to that of supraglacial lakes and moulins. Here, we present observations of crevasse ponding and investigate controls on their hydrological behavior at a fast‐moving, marine‐terminating sector of the GrIS. We map surface meltwater, crevasses, and surface‐parallel stress across a ∼2,700 km2 region using satellite data and contemporaneous uncrewed aerial vehicle (UAV) surveys. From 2017 to 2019 an average of 26% of the crevassed area exhibited ponding at locations that remained persistent between years despite rapid advection. We find that the spatial distribution of ponded crevasses does not relate to previously proposed controls on the distribution of supraglacial lakes (elevation and topography) or crevasses (von Mises stress thresholds), suggesting the operation of some other physical control(s). Ponded crevasse fields were preferentially located in regions of compressive surface‐parallel mean stress, which we interpret to result from the hydraulic isolation of these systems. This contrasts with unponded crevasse fields, which we suggest are readily able to transport meltwater into the wider supraglacial and englacial network. UAV observations show that ponded crevasses can drain episodically and rapidly, likely through hydrofracture. We therefore propose that the surface stress regime influences a spatially heterogeneous transfer of meltwater through crevasses to the bed of ice sheets, with consequences for processes, such as subglacial drainage and the heating of ice via latent heat release by refreezing meltwater.
Ultra-fast single-crystal polymerization of large-sized covalent organic frameworks
Authors: Peng Lan , Guo Qianying , Song Chaoyu , Ghosh Samrat , Xu Huoshu , Wang Liqian , Hu Dongdong , Shi Lei , Zhao Ling , Li Qiaowei , Sakurai Tsuneaki , Yan Hugen , Seki Shu , Liu Yunqi , Wei Dacheng 
Published: August 2021

AbstractIn principle, polymerization tends to produce amorphous or poorly crystalline materials. Efficiently producing high-quality single crystals by polymerization in solvent remains as an unsolved issue in chemistry, especially for covalent organic frameworks (COFs) with highly complex structures. To produce μm-sized single crystals, the growth time is prolonged to >15 days, far away from the requirements in practical applications. Here, we find supercritical CO2 (sc-CO2) accelerates single-crystal polymerization by 10,000,000 folds, and produces two-dimensional (2D) COF single crystals with size up to 0.2 mm within 2~5 min. Although it is the fastest single-crystal polymerization, the growth in sc-CO2 leads to not only the largest crystal size of 2D COFs, but also higher quality with improved photoconductivity performance. This work overcomes traditional concept on low efficiency of single-crystal polymerization, and holds great promise for future applications owing to its efficiency, industrial compatibility, environmental friendliness and universality for different crystalline structures and linkage bonds.
A stretchable and adhesive ionic conductor based on polyacrylic acid and deep eutectic solvents
Authors: Li Gang , Deng Zhihao , Cai Minkun , Huang Kaixi , Guo Mengxue , Zhang Ping , Hou Xingyu , Zhang Yuan , Wang Yueji , Wang Yan , Wu Xiang , Guo Chuan Fei 
Published: August 2021

AbstractHydrogels are a widely used ionic conductor in on-skin electronic and iontronic devices. However, hydrogels dehydrate in the open air and freeze at low temperatures, limiting their real applications when they are attached on skin or exposed to low temperatures. Polymer-ionic liquid gels can overcome these two obstacles, but synthetic ionic liquids are expensive and toxic. In this work, we present an ionic conductor based on polyacrylic acid (PAAc) and deep eutectic solvents (DESs) that well addresses the aforementioned challenges. We polymerize acrylic acid in DESs to get the PAAc–DES gel, which exhibits excellent stretchability (> 1000%), high electrical conductivity (1.26 mS cm−1), high adhesion to the skin (~ 100 N m−1), as well as good anti-drying and anti-freezing properties. We also demonstrate that the PAAc-DES gel can be used as an on-skin electrode to record the surface electromyographic signal with high signal quality, or as a transparent stretchable electrode in iontronic devices that can work at –20 °C. We believe that the PAAc–DES gels are an ideal candidate as epidermal electrodes or transparent stretchable electrodes.
Observation of giant and tunable thermal diffusivity of a Dirac fluid at room temperature
Authors: Block Alexander , Principi Alessandro , Hesp Niels C. H. , Cummings Aron W. , Liebel Matz , Watanabe Kenji , Taniguchi Takashi , Roche Stephan , Koppens Frank H. L. , van Hulst Niek F. , Tielrooij Klaas-Jan 
Published: August 2021

AbstractConducting materials typically exhibit either diffusive or ballistic charge transport. When electron–electron interactions dominate, a hydrodynamic regime with viscous charge flow emerges1–13. More stringent conditions eventually yield a quantum-critical Dirac-fluid regime, where electronic heat can flow more efficiently than charge14–22. However, observing and controlling the flow of electronic heat in the hydrodynamic regime at room temperature has so far remained elusive. Here we observe heat transport in graphene in the diffusive and hydrodynamic regimes, and report a controllable transition to the Dirac-fluid regime at room temperature, using carrier temperature and carrier density as control knobs. We introduce the technique of spatiotemporal thermoelectric microscopy with femtosecond temporal and nanometre spatial resolution, which allows for tracking electronic heat spreading. In the diffusive regime, we find a thermal diffusivity of roughly 2,000 cm2 s−1, consistent with charge transport. Moreover, within the hydrodynamic time window before momentum relaxation, we observe heat spreading corresponding to a giant diffusivity up to 70,000 cm2 s−1, indicative of a Dirac fluid. Our results offer the possibility of further exploration of these interesting physical phenomena and their potential applications in nanoscale thermal management.
Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem
Authors: Koelmel Wolfgang , Kuper Jochen , Kisker Caroline 
Published: August 2021

AbstractOver the last decades the phase problem in macromolecular x-ray crystallography has become more controllable as methods and approaches have diversified and improved. However, solving the phase problem is still one of the biggest obstacles on the way of successfully determining a crystal structure. To overcome this caveat, we have utilized the anomalous scattering properties of the heavy alkali metal cesium. We investigated the introduction of cesium in form of cesium chloride during the three major steps of protein treatment in crystallography: purification, crystallization, and cryo-protection. We derived a step-wise procedure encompassing a “quick-soak”-only approach and a combined approach of CsCl supplement during purification and cryo-protection. This procedure was successfully applied on two different proteins: (i) Lysozyme and (ii) as a proof of principle, a construct consisting of the PH domain of the TFIIH subunit p62 from Chaetomium thermophilum for de novo structure determination. Usage of CsCl thus provides a versatile, general, easy to use, and low cost phasing strategy.
Targeted knockout of the gene OsHOL1 removes methyl iodide emissions from rice plants
Authors: Carlessi Martina , Mariotti Lorenzo , Giaume Francesca , Fornara Fabio , Perata Pierdomenico , Gonzali Silvia 
Published: August 2021

AbstractIodine deficiency represents a public health problem worldwide. To increase the amount of iodine in the diet, biofortification strategies of plants have been tried. They rely on the exogenous administration of iodine to increase its absorption and accumulation. However, iodine is not stable in plants and can be volatilized as methyl iodide through the action of specific methyltransferases encoded by the HARMLESS TO OZONE LAYER (HOL) genes. The release of methyl iodide in the atmosphere represents a threat for the environment due to its ozone depletion potential. Rice paddies are among the strongest producers of methyl iodide. Thus, the agronomic approach of iodine biofortification is not appropriate for this crop, leading to further increases of iodine emissions. In this work, we used the genome editing CRISPR/Cas9 technology to knockout the rice HOL genes and investigate their function. OsHOL1 resulted a major player in methyl iodide production, since its knockout abolished the process. Moreover, its overexpression reinforced it. Conversely, knockout of OsHOL2 did not produce effects. Our experiments helped elucidating the function of the rice HOL genes, providing tools to develop new rice varieties with reduced iodine emissions and thus more suitable for biofortification programs without further impacting on the environment.