bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Terapi Bekam pada Titik Refleksologi dengan Aroma Terapi Lavender Oil Terhadap Penurunan Tekanan Darah pada Penderita Hipertensi
Authors: Wahdini Rizqa , Safarudin Syarif , Oktaviani Diah 
Published: June 2021

Latar Belakang: Hipertensi merupakan gangguan asimptomatik pada tekaan darah yang sering terjadi ditandai dengan peningkatan tekanan darah secara persisten. Penyebab hipertensi belum diketahui dengan pasti penyebabnya. Salah satu terapi komplementer yang dapat digunakan untuk menjaga keseimbangan tekanan darah yaitu terapi bekam yang berfungsi meningkatkan permeabilitas pembuluh darah, dibantu dengan aromaterapi lavender yang memiliki efek relaksasi sehingga mampu memperbaiki metabolism dan memperlancar pembuluh darah. Tujuan Penelitian: Untuk mengetahui pengaruh terapi bekam pada titik refleksologi dengan menggunakan minyak aromaterapi lavender terhadap penurunan tekanan darah pada penderita hipertensi. Jenis penelitian : Metode penelitian ini menggunakan metode kuantitatif yang menggunakan rancangan penelitian quasi experimen dengan pre post test without control. Teknik sampling yang digunakan dalam penelitian ini adalah simple random sampling sehingga diperoleh sampel sebanyak 16 orang. Hasil penelitian : Penelitian ini menunjukkan hasil signifikan yaitu terjadi penurunan tekanan darah pada penderita hipertensi setelah dilakukan intervensi yaitu high hipertensi sebanyak 3 responden dengan persentase sebesar 18,75 persen, hipertensi grade 1 (ringan) sebesar 9 responden dengan persentase 56,25 persen, dan hipertensi grade 2 (sedang) sebanyak 4 responden dengan persentase sebesar 25 persen. Hasil uji wilcoxon didapat nilai P lebih kecil dari 0,05 (P= 0,000). Kesimpulan : Adanya pengaruh terapi bekam pada titik refleksologi dengan aromaterapi lavender oil terhadap penurunan tekanan darah pada penderita hipertensi.
Perubahan Pengetahuan Pekerja Seks Komersial Tentang HIV-AIDS Melalui Upaya Pendidikan Kesehatan Metode Brain Storming
Authors: Akbar Ali , Hidayat Uti Rusdian , Nurwijayanti Suciarti 
Published: June 2021

Pekerja seks komersial merupakan salah satu kelompok resiko yang memegang peranan penting dalam penyebaran HIV AIDS. Upaya yang cukup efektif untuk menekan penyebaran virus tersebut yaitu dengan meningkatkan pengetahuan pekerja mengenai perilaku seksual yang aman melalui metode pendidikan kesehatan yang sesuai.Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan kesehatan HIV AIDS dengan menggunakan metode brain storming terhadap perubahan pengetahuan pekerja seks komersial. Hasil analisis Simple Paired T Test menunjukkan ada perbedaan yang bermakna antara pengetahuan responden sebelum dan sesudah diberikan pendidikan kesehatan dengan metode brain storming (p value = 0,000).
Identificación morfológica y molecular de especies autóctonas trichoderma spp., aisladas de suelos de importancia agrícola
Authors: Sánchez Miranda María Delfina , Moreno Mayorga Luis Francisco , Páramo Aguilera Leandro Alberto 
Published: June 2021

Trichoderma sp. es un género de hongo que está siendo utilizado ampliamente como una alternativa sostenible para el control de enfermedades de plantas y promotor de crecimiento en cultivos de importancia agrícola. Tiene una gran diversidad genética, por lo que el presente estudio pretende identificar y describir morfológica y molecularmente especies provenientes de diferentes fuentes tan diversas como suelo agrícola, tomate triturado, cultivo de plátano, pastos entre otros. En el estudio se encontró 17 aislados de hongos con características en sus colonias similares a Trichoderma spp., los cuales después de observar sus características morfológicas se identificaron presuntivamente como pertenecientes a este género. La caracterización de su conidióforo, fiálides y conidias, demostró que dichos aislados correspondían al género Trichoderma spp. Posteriormente se demostró que los 17 aislados pertenecían al género Trichoderma sp mediante secuenciación, utilizando los cebadores ITS1 (5 TCC GTA GGT GAA CCT GCG G 3) ADNr, encontrándose 7 especies diferentes del hongo en el estudio, las cuales fueron: T. harzianum, T. viride, T. asperellum, T. asperelloide, T. songyi, T. virens y T. breve. De estas especies T. asperellum y T. harzianum, son de vital importancia por ser previamente identificadas como efectivos agentes de control biológico de enfermedades y promotores de crecimiento de plantas y se abre una nueva puerta de investigación con T. breve y T. songyi, ya que muy poco se conoce sobre la aplicación biotecnológica de éstas.
Por que é importante discutir desigualdade
Authors: Mattos Fernando Augusto Mansor de 
Published: June 2021

O artigo destaca três motivos para explicar a crescente importância do tema da desigualdade no debate acadêmico e político das últimas décadas nos países desenvolvidos. Estes motivos são discutidos respectivamente em cada uma das três sessões em que se divide o texto. A primeira sessão destaca a dimensão econômica da desigualdade, mostrando que a ampliação da concentração da renda, desde os anos 1980, e também, ainda com mais intensidade, nos anos 2000, já tem sido motivo suficiente para a retomada do tema. A segunda argumenta que, nos anos 2000, a concentração da renda tem beneficiado o “1% do topo” da distribuição. A explicação acerca dos determinantes desse fenômeno é importante para abrir espaço para uma interpretação mais abrangente da desigualdade, incorporando aspectos políticos, sociais e institucionais ao tema, e destacando as contradições relacionadas ao fato de que a desigualdade vem se ampliando em contexto de vigência de Democracia formal nos diferentes países. A terceira sessão mostra que a interpretação da trajetória da desigualdade sob um ponto de vista multidimensional, conforme proposto anteriormente, permite compreender a natureza dos diversos aspectos de deterioração dos mercados de trabalho nas décadas recentes. A articulação dos três motivos mencionados revela a necessidade de que a desigualdade tenha uma abordagem multidisciplinar e multidimensional. As conclusões ressaltam que a compreensão acerca dos determinantes da trajetória da desigualdade, em todas as suas dimensões, permite reunir elementos para subsidiar informações para a construção de políticas públicas destinadas a enfrentar as crescentes mazelas sociais e também para discutir formas de combater a desigualdade extrema e seus eventuais efeitos deletérios sobre a própria acumulação capitalista.
Study of Four Passive Second Skin Façade Configurations as a Natural Ventilation System During Winter and Summer
Authors: Hamidi Youssef , Malha Mustapha , Bah Abdellah 
Published: June 2021

The fight against climate change is a significant challenge, resulting mainly from the linear and extensive exploitation of natural resources, particularly fossil fuels. Its impacts are now recognized. The current climate models are neither sustainable nor ecological in economic and social terms, especially as we live in a century marked by galloping demography and urbanization. Researchers worldwide have paid great attention to passive solar design strategies such as double skin or Second Skin Façade.
From this point, the present work aims to contribute to a better understanding of the feasibility of using a passive façade as a useful technology for natural ventilation to achieve potential energy savings and improve thermal comfort and indoor air quality. For this purpose, a parametric study was conducted for a room with four different southern facade configurations in six Moroccan climatic zones; the difference between each lies in the vent's position in the entrance and exit. This process was done by using COMSOL Multiphysics software.
Velocity and volume flow rate fields were analyzed. The proposed configurations provided an average volume flow rate between 200 m3/h and 400 m3/h for a surface of 1 m2 of southern façade with an air vent area of 0.1mx0.2m.
The Prevalence and Associated Factors of Protein Energy Malnutrition among under Five Year Children in Pediatric OPDs of Public Health Institution in Yirgalem Town, Southern Ethiopia, 2017
Authors: Tegegne Kaleab Tesfaye , Berisha Iyasu Estiphanos 
Published: June 2021

Introduction: Protein energy malnutrition is one of the leading causes of morbidity and mortality in children under the age of five in developing countries. Ethiopia being one of these countries malnutrition is an important public health problem and among the highest in the world
Objectives: The main objective of this study is to assess the prevalence and associated factors of protein energy malnutrition among under-five children in pediatric OPDs of public health institutions at Yirgalem town, Dale woreda, Sidama zone, SNNPR, Ethiopia from September 18-26, 2017.
Methodology: Institutional based cross sectional study was conducted in pediatric OPDs of public health institutions in Yirgalem town, on a total of 204 children age less than five years from September 18-26, 2017. Study subjects were selected by using quota sampling technique. Interviewer administered structured questionnaire and anthropometric measurements were used to collect data. Data was analysed using SPSS version 20.0statistical software.
Result: This study indicated that the prevalence of stunting wasting and Under-weight was 41.2%, 1.7% and 25% respectively. Factors showed statistically significant association in multivariate analysis were family planning use by mother, children eat together with older siblings and exclusive breast feeding with P-value (0.02), (0.036) and (0.002) respectively.
Conclusion: This study reviled that the prevalence of stunting, wasting and under-weight were higher among under-five children participated in this study. Thus children are at a higher risk of under nutrition related morbidity and mortality. Further progress in under nutrition prevention can be achieved by specifically targeting children at their early age and conducting tailored public education to improve the nutritional status of the study subjects.
Therapeutic effect of and mechanisms underlying the effect of miR-195-5p on subarachnoid hemorrhage-induced vasospasm and brain injury in rats
Authors: Tsai Tai-Hsin , Chang Chih-Hui , Lin Szu-Huai , Su Yu-Feng , Tsai Yi-Cheng , Yang Sheau-Fang , Lin Chih-Lung 
Published: June 2021

Objectives
There is much evidence suggesting that inflammation contributes majorly to subarachnoid hemorrhage (SAH)-induced cerebral vasospasm and brain injury. miRNAs have been found to modulate inflammation in several neurological disorders. This study investigated the effect of miR-195-5p on SAH-induced vasospasm and early brain injury in experimental rats.

Methods
Ninety-six Sprague-Dawley male rats were randomly and evenly divided into a control group (no SAH, sham surgery), a SAH only group, a SAH + NC-mimic group, and a SAH + miR-195-5p group. SAH was induced using a single injection of blood into the cisterna magna. Suspensions containing NC-mimic and miR-195-5p were intravenously injected into rat tail 30 mins after SAH was induced. We determined degree of vasospasm by averaging areas of cross-sections the basilar artery 24h after SAH. We measured basilar artery endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κ B), phosphorylated NF-κ B (p-NF-κ B), inhibitor of NF-κ B (Iκ Bα) and phosphorylated-Iκ Bα (p-Iκ Bα). Cell death assay was used to quantify the DNA fragmentation, an indicator of apoptotic cell death, in the cortex, hippocampus, and dentate gyrus. Tumor necrosis factor alpha (TNF-α) levels were measured using sample protein obtained from the cerebral cortex, hippocampus and dentate gyrus.

Results
Prior to fixation by perfusion, there were no significant physiological differences among the control and treatment groups. SAH successfully induced vasospasm and early brain injury. MiR-195-5p attenuated vasospasam-induced changes in morphology, reversed SAH-induced elevation of iNOS, p-NF-κ B, NF-κ B, and p-Iκ Bα and reversed SAH-induced suppression of eNOS in the basilar artery. Cell death assay revealed that MiR-195-5p significantly decreased SAH-induced DNA fragmentation (apoptosis) and restored TNF-α level in the dentate gyrus.

Conclusion
In conclusion, MiRNA-195-5p attenuated SAH-induced vasospasm by up-regulating eNOS, down-regulating iNOS and inhibiting the NF-κ B signaling pathway. It also protected neurons by decreasing SAH-induced apoptosis-related cytokine TNF-α expression in the dentate gyrus. Further study is needed to elucidate the detail mechanism underlying miR-195-5p effect on SAH-induced vasospasm and cerebral injury. We believe that MiR-195-5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury.
The protective effect ofMoringa oleiferaplant extract against glutamate-induced DNA damage and reduced cell viability in a primary retinal ganglion cell line
Authors: Amina Musarat , Bhat Ramesa Shafi , Al-Dbass Abeer M. , Musayeib Nawal M. , Fahmy Rania , Alhadlaq Leen , El-Ansary Afaf 
Published: June 2021

BackgroundGlutamate excitotoxicity can cause DNA damage and is linked to many retinal and neurological disorders. In mammals, the visual signal from the eyes to the brain is conducted only by retinal ganglion cells (RGCs), which can be damaged by overstimulation of glutamate receptors.MethodologyWe examined the protective effects ofMoringa oleiferaseed extract against glutamate-induced DNA damage in RGCs. RGCs cells were treated with 5, 10, 50, or 100 µg/ml ofM. oleiferaseed extract and glutamate separately and then assessed for DNA damage using the comet assay. We also evaluated the viability of the RGCs after both treatments using the MTT test. Additionally, RGCs were pretreated withM.oleiferaseed extract (50 or 100 µg/ml) for 2 h before glutamate treatment (100 µg/ml) to determine the potential protective effects ofM. oleifera. We performed a phytochemical analysis of theM. oleiferaseed extract using standard reactions.ResultsTheM. oleiferaseed extract was found to be rich in many phytochemicals. We observed a significant dose-dependent elevation in all comet assay variables in glutamate-treated RGCs, whereasM. oleiferaseed extract treatments did not show any significant change in DNA integrity.ConclusionM. oleiferaseed extract demonstrates neuroprotective effects, which suggests it may help to prevent the development of many neurodegenerative disorders.
An Analysis of Financial Performance of the Coal Mining Industries: A Case Study of Raniganj Coalfield of Eastern Coalfield Limited
Authors: Maji Gosai , Malik Uma Sankar 
Published: June 2021

The leading coalfield of India, the Raniganj coalfield under Eastern Coalfield Limited is recognised as the birth place of the Indian coal mining industry and one of the most prominent coalfields not only in India but also in the world. It is also the second largest supplier of superior quality of coal in the nation at present subsequent to Jharia coalfield. Raniganj and Jharia Coalfields (RCF & JCF) can be recognised as mirror image in the history of coal mining in India. Both the coal mining areas are witnessing mining of coal for more than 230 years. With the shifting of economic structure of the country, the cold filed region has registered quite a lot of ups and down in its financial performance. From this point of view the current paper is an attempt to assess the financial performance in the field of mining segment of Raniganj Coal Field, the most important coal producer in West Bengal. The whole study is entirely based on secondary data. A period of five year from 2014-15 to 2019-20 has been determined for the study. The data have been tabulated, analysed and interpreted with the help of Z Score Model and Economic Value Added (EVA) based on financial ratios. It is observed from the analysis of various financial ratios that the revenue earning capability, liquidity condition and long-standing solvency situation of RCF, is to a certain extent good during the entire study period and the level of bankruptcy situation is also very low.
CBNAAT Based Identification and Demographic Pattern of Drug Resistant Mycobacterium Tuberculosis in South Kashmir, India- a One Year Retrospective Study
Authors: Hakkak Rubeena , Rishi Saqib , Bhat Javid Ahmed 
Published: June 2021

India is the highest TB burden country in the world having an estimated incidence of 26.9 lakh cases in 2019. With a population of 1.32 billion, India has the highest burden of drug resistant TB (DR-TB) in the world. North zone of India is the second highest MDR-TB prevalent zone after the West zone of India. MDR TB treatment involves prolonged treatment with injectable second-line drugs, associated with more adverse effects, suboptimal treatment outcomes and higher risks of mortality compared to patients with drug-sensitive TB and those with lesser resistant forms of TB.
Materials methods: This retrospective study was conducted in the department of Microbiology Government Medical College Anantnag, data was analyzed from March 2017 to February 2018. Non-sterile specimens were processed by Modified Petroff Method. Sterile specimens were concentrated by centrifugation and smear and cultures was inoculated from the sediment. CBNAAT assay was performed by Gene Xpert (Cepheid) 4 system according to the manufacturers’ recommendations.
Results: Of the total 1497 clinically suspected tuberculosis specimens collected, 1370 (91.5%) were pulmonary and 127 (8.5%) were presumptive extra pulmonary tuberculosis received from different anatomical sites. Maximum clustering of cases was seen in 10-20 years age group. Out of the total 1497 samples 200 were CBNAAT confirmed Mycobacterium Tuberculosis positive samples. In which 155 were pulmonary and 45 were extra pulmonary. The average percentage positivity rate (i.e. percentage of MTB positive samples out of total samples tested) was 13.3% (200/1497). Rifampicin resistance (RR-TB) was seen in 5.5% (11/200) samples. Out of the samples detected positive (200): 155 were pulmonary samples and out of these 155 pulmonary samples 8 were found to be RR MTB 5.1% (8/155). Also out of the 200 positive samples 45 were extra pulmonary and out of these 45 extra pulmonary samples 3 were found to be RR MTB 6.6% (3/45).
Conclusion: In this study we found that in our region 5.5% cases of TB were RR-TB, 3.2% were new cases and 13% RR-TB was seen in previously treated cases of MTB. The screening of drug resistance has to be expanded to offer universal DST including expanded DST .The second and most important activity is to strengthen drug resistance surveillance under the various national programs with inclusion of laboratories in the private sector as well. The state level regional studies also give us the opportunity to plan and execute intervention prioritization, based on the drug resistance trends observed.
Enantioselective Organocatalyzed aza‐Michael Addition Reaction of 2‐Hydroxybenzophenone Imines to Nitroolefins under Batch and Flow Conditions
Authors: Guerrero‐Corella Andrea , Valle‐Amores Miguel A. , Fraile Alberto , Alemán José 
Published: June 2021

AbstractHerein, an asymmetric organocatalytic aza‐Michael addition reaction of ketimines to nitroolefins is presented. The use of 2‐hydroxybenzophenone imine improves the enantioselective addition of N‐centered nucleophiles to nitroalkenes by means of intramolecular hydrogen bond formation at the imine moiety. Moreover, the versatility of the process is demonstrated under both batch and flow conditions, showing the synthesis of a large variety of nitroamine derivatives with excellent yields and enantioselectivities. In addition, we applied this methodology to the formal synthesis of VNI, a drug‐like scaffold for the treatment of Chagas disease.magnified image
Exploring Transport Behavior in Hybrid Perovskites Solar Cells via Machine Learning Analysis of Environmental‐Dependent Impedance Spectroscopy
Authors: Kim Dohyung , Muckley Eric S. , Creange Nicole , Wan Ting Hei , Ann Myung Hyun , Quattrocchi Emanuele , Vasudevan Rama K. , Kim Jong H. , Ciucci Francesco , Ivanov Ilia N. , Kalinin Sergei V. , Ahmadi Mahshid 
Published: June 2021

AbstractHybrid organic–inorganic perovskites are one of the promising candidates for the next‐generation semiconductors due to their superlative optoelectronic properties. However, one of the limiting factors for potential applications is their chemical and structural instability in different environments. Herein, the stability of (FAPbI3)0.85(MAPbBr3)0.15 perovskite solar cell is explored in different atmospheres using impedance spectroscopy. An equivalent circuit model and distribution of relaxation times (DRTs) are used to effectively analyze impedance spectra. DRT is further analyzed via machine learning workflow based on the non‐negative matrix factorization of reconstructed relaxation time spectra. This exploration provides the interplay of charge transport dynamics and recombination processes under environment stimuli and illumination. The results reveal that in the dark, oxygen atmosphere induces an increased hole concentration with less ionic character while ionic motion is dominant under ambient air. Under 1 Sun illumination, the environment‐dependent impedance responses show a more striking effect compared with dark conditions. In this case, the increased transport resistance observed under oxygen atmosphere in equivalent circuit analysis arises due to interruption of photogenerated hole carriers. The results not only shed light on elucidating transport mechanisms of perovskite solar cells in different environments but also offer an effective interpretation of impedance responses.
Yield performance of inbred rice grown under labor‐saving crop establishment methods
Authors: Huang Min , Chen Ge , Chen Jiana , Cao Fangbo , Li Zusheng , Chen Yumei , Liu Longsheng , Zou Yingbin 
Published: June 2021

AbstractLabor‐saving crop establishment methods have rapidly developed for rice (Oryza sativa L.) production in China to address a labor shortage in agricultural production resulting from urban expansion, and many rice farmers who adopt such methods prefer to choose inbred varieties with reduced seed costs. This study aimed to determine which of two labor‐saving establishment methods, zero tillage and direct seeding (ZTDS) and rotavator tillage and mechanical transplanting (RTMT), achieves higher grain yield in inbred rice. Field experiments were conducted at two sites across 3 yr to determine grain yield and yield attributes of elite inbred rice cultivar Jinlongsimiao, established under ZTDS and RTMT. Results showed that RTMT produced an 11% higher grain yield than ZTDS. Higher spikelet number per panicle was observed under RTMT compared with ZTDS, but spikelet number per square meter was not necessarily higher because it was compensated for by a reduced panicle number per square meter. The RTMT‐established rice conferred higher spikelet filling percentage but lower grain weight than ZTDS‐established rice. There was no consistent or significant difference in crop growth rate, total biomass production, or the source/sink ratio between RTMT and ZTDS rice. The RTMT method produced a higher harvest index than ZTDS. These results suggest that RTMT is the favorable method for inbred rice establishment to improve the partitioning of assimilates and, consequently, increase spikelet filling percentage and grain yield compared with ZTDS.