bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Bisnis Fashion Muslim Dengan Pendekatan Business Model Canvas (BMC)
Authors: Susilowati Isnurrini Hidayat 
Published: November 2021

Abstrak - Dampak pandemi covid 19 sangat dirasakan oleh semua sektor usaha termasuk sektor fashion. Oleh karena itu dibutuhkan strategi-strategi pengembangan bisnis agar usaha sektor fashion tetap bisa bertahan. Nayla Collection adalah salah satu usaha sektor UMKM dibidang fashion muslim dikota Depok dan agar usaha bisa bertahan dan berkembang dalam masa pandemi covid 19 ini maka harus mempunyai strategi bisnis. Strategi yang digunakan adalah dengan menggunakan alat bantu Business Model Canvas (BMC). Penelitian dilakukan menggunakan deskriptif kualitatif dengan data primer dan sekunder. Tujuan penelitian adalah untuk mengetahui strategi untuk mengembangkan bisnis melalui Business Model Canvas (BMC), dianalisa menggunakan SWOT (Strenght, Weakness, Oportunity dan Threat) . Penelitian yang dihasilkan disertai hasil dari analisa SWOT adalah strategi perbaikan dengan penambahan mitra dengan perusahaan e-commerce, pembuatan web untuk promosi produk dan bekerjasama dengan komunitas ibu-ibu muda. Mengedukasi pelanggan dalam mengkombinasikan produk yang akan dikenakan merupakan penambahan elemen value proposition. Pemilik toko fashion muslim Nayla Collection bisa menjadikan hasil penelitian tersebut sebagai pedoman dalam mengembangkan bisnisnya. Kata Kunci: Analisis Bisnis, Analisis SWOT, Business Model Canvas
Pengaruh Leverage dan Likuiditas Terhadap Kebijakan Deviden
Authors: Alawiyah Al , Prasetyo Galih , Fatimah Siti 
Published: November 2021

Abstrak - Perusahaan dituntut untuk dapat mempertahankan bisnisnya, tumbuh, dan meningkatkan daya saing dengan tetap memperoleh keuntungan (sustainable competitive growth). Gabungan Pengusaha Makanan dan Minuman Indonesia (GAPMMI) menyatakan bahwa industri makanan dan minuman menjadi salah satu sektor yang tertekan di tahun 2020 terutama pada saat pandemic Covid-19. Penurunan terbesar disebabkan oleh menurunnya konsumsi rumah tangga. Konsumsi rumah tangga berkontribusi sebesar 57% terhadap Produk Domestik Bruto (PDB). Sementara itu, industri makanan dan minuman hanya berkontribusi sebesar 23,8% terhadap PDB pada tahun 2020. Konsumsi rumah tangga turun 5,02 persen ke 2,84 persen selama kuartal I, dengan 44 persen berasal dari kontribusi makanan dan minuman. Padahal pengeluaran per kapita masyarakat kita 50 persennya untuk pangan, konsumen dan channel penjualan juga mulai bergeser ke pembelian online. Penelitian ini bertujuan untuk menguji pengaruh leverage dan likuiditas terhadap kebijakan dividen. Penelitian ini menggunakan 15 perusahan makanan dan minuman yang tedaftar di Bursa Efek Indonesia dipilih dengan metode purposive random sampling periode tahun 2016 sampai dengan tahun 2020. Metode statistik yang digunakan untuk menguji hipotesis adalah SEM-PLS (Structural Equation Model – Partial Least Square). Hasil penelitian menunjukkan bahwa variabel leverage tidak berpengaruh signifikan terhadap kebijakan dividen sedangkan pada variabel likuditas terdapat pengaruh positif signifikan terhadap kebijakan dividen. Kata Kunci: Leverage, Likuiditas, Kebijakan Dividen
Adaptasi Kebiasaan Baru Selama Pandemic melalui Upaya Peningkatan Produktifitas Wirausaha Mandiri Menuju Ekonomi Berkeadilan
Authors: Yuliani Nafisah , Pramestari Diah , Henni Henni 
Published: November 2021

Abstrak-This study aims to determine the efforts to increase the productivity of independent entrepreneurs towards a just economy as a form of adaptation during a pandemic. The sample consists of students who already have a business or who do not have a business as many as 137 students. The data was collected through a mail survey (google forms) and analyzed by descriptive method to find out the description of the respondents to the problem under study. The results of this study indicate that efforts to increase entrepreneurial productivity through improving the characteristics of superior entrepreneurs, improving marketing strategies and improving business performance are a new form of adaptation during the pandemic in order to realize independent entrepreneurship towards a just economy. The results of this study also have two implementations: (1) theoretical implementation for the results of this study is to realize independent entrepreneurship towards a just economy, then the application of competitive strategies in the form of Cost Leadership Strategy, Differentiation Strategy, Innovation Strategy ( Innovation Strategy), Growth Strategy, Alliance Strategy, (2) managerial implementation for the results of this study is an effort to increase entrepreneurial productivity through improving the characteristics of superior entrepreneurs, improving marketing strategies and improving business performance as a form of adaptation. only during the pandemic to realize independent entrepreneurship towards a just economy. This provides motivation to survive in the midst of high competition with good ICT mastery and expand overseas Keywords: Adapting to New Habits, Productivity, Self-Employment
Book Reviews
Authors: Willemsen Steven , Slugan Mario , Weissmann Elke , Bolton Lucy 
Published: November 2021

Marina Grishakova and Maria Poulaki, eds.Narrative Complexity: Cognition, Embodiment, Evolution.Lincoln: University of Nebraska Press, 2019, 468 pp., $75.00 (hardcover). ISBN: 9780803296862.Maarten Coëgnarts.Film as Embodied Art: Bodily Meaning in the Cinema of Stanley Kubrick.Brookline: Academic Studies Press, 2019, xxxv + 228 pp., $120 (paperback), ISBN: 978-1-64469-112-0. [Also available for free under a CC BY-NC-ND 4.0 license with support from Knowledge Unlatched, ISBN: 978-1-64469-113-7].Marsha F . Cassidy.Television and the Embodied Viewer: Affect and Meaning in the Digital Age.New York: Routledge, 2020, 216 pp., $155.00, ISBN: 9781138240766.Sarah Cooper.Film and the Imagined Image.Edinburgh: Edinburgh University Press, 2019, 208 pp., $24.95 (paperback), ISBN: 9781474452793.
Traumatic rupture of thoracic epidural capillary hemangioma resulting in acute neurologic deficit: illustrative case
Authors: Kidwell Reilly L. , Stone Lauren E. , Goodwill Vanessa , Ciacci Joseph D. 
Published: November 2021

BACKGROUND
Thoracic epidural capillary hemangioma is exceedingly rare, with only a few reported cases. The typical presentation usually includes chronic, progressive symptoms of spinal cord compression in middle-aged adults. To the authors’ knowledge, this case is the first report in the literature of acute traumatic capillary hemangioma rupture.

OBSERVATIONS
A 22-year-old male presented with worsening lower extremity weakness and paresthesias after a fall onto his spine. Imaging showed no evidence of spinal fracture but revealed an expanding hematoma over 24 hours. Removal of the lesion demonstrated a ruptured capillary hemangioma.

LESSONS
This unique case highlights a rare occurrence of traumatic rupture of a previously unknown asymptomatic thoracic capillary hemangioma in a young adult.
Management of pediatric clival chordoma with extension to the craniocervical junction and occipito-cervical fusion: illustrative case
Authors: Liu Matthew A. , Gendreau Julian L. , Loya Joshua J. , Brown Nolan J. , Keith Amber , Sahyouni Ronald , Abraham Mickey E. , Gonda David , Levy Michael L. 
Published: November 2021

BACKGROUND
Chordomas are rare malignant neoplasms that develop from the primitive notochord with < 5% of the tumors occurring in pediatric patients younger than the age of 20. Of these pediatric chordomas, those affecting the craniocervical junction (C1–C2) are even more rare; therefore, parameters for surgical management of these pediatric tumors are not well characterized.

OBSERVATIONS
In this case, a 3-year-old male was found to have a clival chordoma on imaging with extension to the craniocervical junction resulting in spinal cord compression. Endoscopic-assisted transoral transclival approach for clival tumor resection was performed first. As a second stage, the patient underwent a left-sided far lateral craniotomy and cervical laminectomy for resection of the skull base chordoma and instrumented fusion of the occiput to C3. He made excellent improvements in strength and dexterity during rehab and was discharged after 3 weeks.

LESSONS
In pediatric patients with chordoma with extension to the craniocervical junction and spinal cord compression, decompression with additional occipito-cervical fusion appears to offer a good clinical outcome. Fusion performed as a separate surgery before or at the same time as the initial tumor resection surgery may lead to better outcomes.
Intradural lumbar radicular arteriovenous malformation mimicking perimedullary arteriovenous malformation of the conus medullaris: illustrative case
Authors: Koyanagi Izumi , Chiba Yasuhiro , Imamura Hiroyuki , Osanai Toshiya 
Published: November 2021

BACKGROUND
Intradural radicular arteriovenous malformation (AVM) of the cauda equina is a rare entity of spinal AVMs. Because of the specific arterial supply of the conus medullaris and cauda equina, AVMs in this area sometimes present with confusing radiological features.

OBSERVATIONS
The authors reported a rare case of intradural radicular AVM arising from the lumbar posterior root. The patient presented with urinary symptoms with multiple flow void around the conus medullaris, as shown on magnetic resonance imaging. Digital subtraction angiography demonstrated arteriovenous shunt at the left side of the conus medullaris fed by the anterior spinal artery via anastomotic channel to the posterior spinal artery and rich perimedullary drainers. There was another arteriovenous shunt at the L3 level from the left L4 radicular artery. Preoperative diagnosis was perimedullary AVM with radicular arteriovenous fistula. Direct surgery with indocyanine green angiography revealed that the actual arteriovenous shunt was located at the left L4 posterior root. The AVM was successfully treated by coagulation of feeding branches.

LESSONS
Unilateral arteriovenous shunt fed by either posterior or anterior spinal artery at the conus medullaris may include AVM of the cauda equina despite abundant perimedullary venous drainage. Careful pre- and intraoperative diagnostic imaging is necessary for appropriate treatment.
Diễn biến nồng độ bụi mịn PM2.5 và chỉ số chất lượng không khí (AQI) ở Hà Nội trong đợt bùng phát dịch bệnh Covid-19 lần thứ 4
Authors: Việt Hoàng Tuấn , Lượng Nguyễn Đức , Anh Đoàn Ngọc , Trung Bùi Quang 
Published: November 2021

Trong các đợt bùng phát dịch bệnh Covid-19 vừa qua, do tác động của một số biện pháp giãn cách xã hội (hạn chế đi lại, tạm dừng các hoạt động sản xuất, kinh doanh, buôn bán, tập trung đông người, …), chất lượng không khí (CLKK) ở thành phố Hà Nội có thể đã được cải thiện. Mục đích của nghiên cứu này là đánh giá diễn biến nồng độ của bụi mịn PM2.5 và chỉ số chất lượng không khí (AQI) ở TP. Hà Nội trước, trong và sau các khoảng thời gian bùng phát dịch Covid-19 lần thứ 4 (từ 04/4/2021 – 30/6/2021). Kết quả phân tích diễn biến nồng độ trung bình 24 giờ của bụi PM2.5 và chỉ số CLKK ngày (AQId) cho thấy CLKK trong khoảng thời gian diễn ra dịch bệnh (tháng 5 và 6/2021) tốt hơn so với khoảng thời gian 01 tháng trước khi dịch bệnh diễn ra (tháng 4/2021). Nồng độ trung bình của bụi PM2.5 trong giai đoạn giãn cách so với trước khi giãn cách xã hội giảm từ 10,7% đến 56,5%. Kết quả nghiên cứu đã phản ánh sự ảnh hưởng tích cực của việc thực hiện các biện pháp giãn cách xã hội của Thành phố tới sự cải thiện của CLKK trong các khoảng thời gian diễn ra đại dịch Covid-19 tại Hà Nội.
Đánh giá hiệu quả giảm phát thải CO2 của bê tông chất lượng siêu cao sử dụng tổ hợp phụ gia khoáng silica fume và tro bay
Authors: Bình Trần Đức , Đồng Phạm Sỹ , Thắng Nguyễn Công , Tuấn Nguyễn Văn , Anh Phạm Xuân , Tấn Trần Văn 
Published: November 2021

Bê tông chất lượng siêu cao (UHPC) là thế hệ bê tông mới với các tính chất vượt trội về tính công tác, tính chất cơ học (cường độ nén > 120 MPa), và độ bền lâu. Tuy vậy, việc phát triển bê tông này dẫn đến tác động bất lợi lớn về môi trường khi lượng xi măng sử dụng (thông thường) là 900-1000 kg/m3. Một trong những giải pháp hiệu quả là sử dụng các phụ gia khoáng thay thế một phần xi măng nhưng vẫn đạt các tính chất mong muốn. Bài báo này nghiên cứu đánh giá hiệu quả phát thải CO2 (theo cách tiếp cận vòng đời sản phẩm) của UHPC sử dụng đơn phụ gia khoáng tro bay (FA), silica fume (SF) và hỗn hợp của chúng. Kết quả cho thấy lượng phát thải CO2 giảm 23,3%, 44,3%, 30,9% khi sử dụng FA, SF, và hỗn hợp SF+FA thay thế xi măng.
Correlation Between Neutrophil to Lymphocyte Ratio and Myocardial Injury in Population Exposed to High Altitude
Authors: He Siyi , He Shengdong , Yang Yongxiang , Li Bin , Gao Liang , Xie Qingyun , Zhang Lin 
Published: November 2021

Objective: Myocardial injury is a severe complication in population exposed to high altitude. As a new biomarker for inflammatory response, neutrophil to lymphocyte ratio (NLR) has been widely used to predict the prognosis of various diseases. In this study, we intend to explore the risk factors for myocardial injury at high altitude and examine the relationship between NLR level and development of myocardial injury.Methods: Consecutive patients admitted to a secondary general hospital at high altitude from June 2019 to May 2020 were selected into this retrospective study. Clinical and biochemical data were collected. According to the results of lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzymes (CK-MB), and aspartate amino transferase (AST), patients were divided into myocardial injury group and normal group.Results: A total of 476 patients were enrolled in this study. Myocardial injury occurred in 158 patients (33.2%). We found that altitude, NLR, hemoglobin, total bilirubin, total cholesterol, and lipoprotein A in myocardial injury group were significantly higher than that in normal group (P &lt; 0.05), while platelet count in myocardial injury group was significantly lower than that in normal group (P &lt; 0.05). Logistic multivariate regression analysis revealed that there was an independent relationship between myocardial injury and smoke, NLR, hemoglobin (P &lt; 0.05). By using Spearman correlation analysis, NLR was proved to have a significant positive correlation with LDH, CK, and CK-MB (P &lt; 0.05) instead of AST. A receiver operating characteristic (ROC) curve was drawn to demonstrate that NLR could significantly predict the occurrence of myocardial injury with an area under the curve (AUC) of 0.594 (95% CI: 0.537–0.650, P &lt; 0.05), and the level of 2.967 (sensitivity = 38.0%, specificity = 83.6%) was optimal cutoff value.Conclusion: The incidence of myocardial injury is high in population at high altitude. Smoke, hemoglobin, and NLR are independent factors related to myocardial injury. As a convenient and efficient marker, NLR is found to be closely associated with myocardial enzymes and have a predict role in the occurrence of myocardial injury. This study will provide a theoretical basis on NLR for the early diagnosis of myocardial injury at high altitude.
Case Report: A Rare Complication Following Catheter Ablation of Scar-Related Ventricular Tachycardia
Authors: Xu Xiaoyong , Ye Ming , Sun Yaxun , Liu Qiang , Ma Fusheng , Jiang Chenyang 
Published: November 2021

Background: The substrate for ventricular tachycardia (VT) in patients with structural heart disease is usually complex and often requires extensive ablation. As a result, the incidence of major procedure-related complications has been reported to be higher when compared to patients without structural heart disease. In this study, we present a rare complication after extensive substrate modification of scar-related VT.Case: A 65-year-old man with ischemic cardiomyopathy was referred to the electrophysiology laboratory for radiofrequency ablation of VT following repetitive implantable cardioverter defibrillator shocks within a short period. As with hemodynamic intolerance of induced VT, an approach involving extensive endocardial substrate modification to reduce the arrhythmogenicity of the scars was adopted. After the procedure, the heart function of the patient deteriorated significantly. The postprocedural ECG showed a bizarre, extremely wide surface QRS complex (360 ms), termed as homologous ventricular separation. The pronounced dyssynchrony of the ventricle was corrected by an upgrade to cardiac resynchronization therapy with defibrillation (CRT-D). As a result, the symptoms of the patient improved significantly. The width of the intrinsic QRS complex was not recovered during an 18-month follow-up.Conclusion: Homologous ventricular separation is a rare arrhythmia, manifested as two separated QRS waves. This case report demonstrates, for the first time, that homologous ventricular separation may occur after extensive substrate modification of scar-related VT. CRT-D can correct the dyssynchronous ventricle caused by homologous ventricular separation.
Low Intrinsic Aerobic Capacity Limits Recovery Response to Hindlimb Ischemia
Authors: Granier Elizabeth , Zakari Madaniah O. , Alsahly Musaad B. , Koch Lauren G. , Britton Steven , Katwa Laxmansa C. , Lust Robert M. 
Published: November 2021

Introduction: In this study, we determined the influence of intrinsic exercise capacity on the vascular adaptive responses to hind limb ischemia. High Capacity Running, HCR; Low Capacity Running, LCR, rats were used to assess intrinsic aerobic capacity effects on adaptive responses to ischemia.Methods: Muscle samples from both ischemic and non-ischemic limb in both strains were compared, histologically for the muscle-capillary relationship, and functionally using microspheres to track blood flow and muscle stimulation to test fatigability. PCR was used to identify the differences in gene expression between the phenotypes following occlusive ischemia.Results: Prior to ligation, there were not significant differences between the phenotypes in the exhaustion time with high frequency pacing. Following ligation, LCR decreased significantly in the exhaustion time compare with HCRs (437 ± 47 vs. 824 ± 56, p &lt; 0.001). The immediate decrease in flow was significantly more severe in LCRs than HCRs (52.5 vs. 37.8%, p &lt; 0.001). VEGF, eNOS, and ANG2 (but not ANG1) gene expression were decreased in LCRs vs. HCRs before occlusion, and increased significantly in LCRs 14D after occlusion, but not in HCRs. LCR capillary density (CD) was significantly lower at all time points after occlusion (LCR 7D = 564.76 ± 40.5, LCR 14D = 507.48 ± 54.2, both p &lt; 0.05 vs. HCR for respective time point). NCAF increased significantly in HCR and LCR in response to ischemia.Summary: These results suggest that LCR confers increased risk for ischemic injury and is subject to delayed and less effective adaptive response to ischemic stress.
MiR-17-5p Inhibits TXNIP/NLRP3 Inflammasome Pathway and Suppresses Pancreatic β-Cell Pyroptosis in Diabetic Mice
Authors: Liu Sijun , Tang Ge , Duan Fengqi , Zeng Cheng , Gong Jianfeng , Chen Yanming , Tan Hongmei 
Published: November 2021

Objective: Diabetes mellitus is a chronic progressive inflammatory metabolic disease with pancreatic β-cells dysfunction. The present study aimed to investigate whether miR-17-5p plays a protective effect on pancreatic β-cells function in diabetes mellitus (DM) mice and dissect the underlying mechanism.Methods: C57BL/6J mice were randomly divided into control, DM, DM + Lentivirus negative control (LV-NC), and DM + Lenti-OE™ miR-17-5p (LV-miR-17-5) groups. DM was established by feeding a high-fat diet and intraperitoneal injection with streptozotocin (STZ) in mice. Blood glucose and glucose tolerance in circulation were measured. Meanwhile, the activation of nod-like receptor protein 3 (NLRP3) inflammasome, pancreas pyroptosis, and the expression of miR-17-5p and thioredoxin-interacting protein (TXNIP) were detected in the pancreas of DM mice. Pancreatic β-cell line INS-1 subjected to different concentrations of glucose was used in in vitro experiments.Results: Compared with control mice, glucose tolerance deficit, elevated blood glucose level, and decreased pancreatic islet size, were presented in DM mice, which was associated with a downregulation of miR-17-5p. Importantly, exogenous miR-17-5p alleviated pancreas injury, and consequently improved glucose tolerance and decreased blood glucose in DM mice. In vitro experiments showed that high glucose decreased miR-17-5p expression and impaired insulin secretion in INS-1 cells. Mechanistically, miR-17-5p inhibited the expression of TXNIP and NLRP3 inflammasome activation, and thus decreased pancreatic β-cell pyroptosis.Conclusion: Our results demonstrated that miR-17-5p improves glucose tolerance, and pancreatic β-cell function and inhibits TXNIP/NLRP3 inflammasome pathway-related pyroptosis in DM mice.
Multielemental Determination of Rare Earth Elements in Seawater by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) After Matrix Separation and Pre-concentration With Crab Shell Particles
Authors: Li Danyi , Wang Xunuo , Huang Ke , Wang Zenghuan 
Published: November 2021

Considering the unique characteristics of rare earth elements (REEs), the presence of REEs beyond specific limits will adversely affect the environment and it can be employed as a powerful probe for investigating hydrogeochemical processes. This requires sensitive determination of REEs in natural seawater. A matrix separation and pre-concentration technique using the mini-column packed with crab shell particles (CSPs) by inductively coupled plasma mass spectrometry (ICP-MS) as a means of determination has been developed. The aim of the proposed method was to simultaneously determine 16 REEs (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu) at trace or ultra-trace concentrations in seawater. The biosorption capacity of CSPs was found to achieve 1.246–1.250 mg g−1 for all elements. In order to optimize performance of the method, the effects of analytical parameters concerning oscillation time, solution pH, salt concentration and eluent concentration were explored. Under the optimal conditions, the detection limits of REEs ranged 0.0006–0.0088 μg L−1, and relative standard deviations (n = 7) varied between 0.55 and 1.39%. The accuracy of developed method was evidenced by applying it to the analysis of REEs in seawater samples, with the overall recoveries at a level of 95.3 and 104.4%. Together, this work provides a promising and cost-effective CSPs-based pretreatment approach for REEs detection in sea environment.
Successful Immunotherapy for Pancreatic Cancer in a Patient With TSC2 and SMAD4 Mutations: A Case Report
Authors: Ye Yanghui , Zheng Song 
Published: November 2021

BackgroundPancreatic cancer has a poor prognosis, and it is traditionally treated with chemotherapy. Fortunately, immunotherapy has rapidly changed the landscape of solid tumor treatment, and improving the survival of cancer patients. However, pancreatic cancer is non-immunogenic, and single agent immunotherapies are unfavorable to its prognosis.Case PresentationHere, we report a case of stage IV pancreatic cancer in a patient with TSC2 and SMAD4 mutations treated with immunotherapy when the disease progressed after multi-line chemotherapy. Next generation sequencing (NGS) confirmed the presence of TSC2 and SMAD4 mutations and microsatellite stability (MSS). When the disease progressed after chemotherapy, a combination strategy was devised consisting of chemotherapy (S-1) and sintilimab. The patient had a partial response to therapy with this regimen, the lesions were significantly reduced and nearly disappeared. In metastatic pancreatic cancer, responses of this magnitude are rarely seen.ConclusionsThis outcome reveals that this combination can be effective in treating metastatic pancreatic cancer, especially in pancreatic cancer patients with SMAD4 and TSC2 mutations. This may help increase the use of this therapy in large-scale clinical research.