bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porokeratotic eccrine ostial and dermal duct nevus associated with an 11 megabase 3p deletion
Authors: Castle Alison M. R. , Ramien Michele L. , Kanigsberg Nordau , El Demellawy Dina , McGowan‐Jordan Jean , Beaulieu Bergeron Melanie , Armour Christine M. 
Published: December 2021

AbstractPorokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare eccrine hamartoma; the etiology is incompletely understood. A patient presented with congenital, widespread PEODDN. Clinical assessment, histopathologic, cytogenetic, and molecular genetic investigations on affected cells were pursued. Histopathology confirmed PEODDN, and chromosomal microarray on affected tissues identified a mosaic 3p26.3p25.3 deletion in affected tissues. This 11Mb deletion encompasses 47 OMIM genes. We propose that this and other chromosomal deletions may be implicated in some cases of PEODDN, suggesting locus heterogeneity and underscoring the importance of incorporating cytogenetic and molecular investigations into the multidisciplinary care of individuals with suspected mosaic genetic skin disorders.
Effect of Different Energy Densities of 915 nm Low Power Laser on the Biological Behavior of Human Gingival Fibroblast Cells In Vitro
Authors: Sadatmansouri Saeed , Agahikesheh Bahar , Karimi Mohammadreza , Etemadi Ardavan , Saberi Sogol 
Published: December 2021

ABSTRACTPhotobiomodulation is recognized as an effective method for adjunct therapy in periodontal treatments. Our purpose in this study was to investigate the effects of different energy densities of 915 nm diode laser on the viability and viability capacity of human gingival fibroblast cells. Cell samples were examined in five groups, including four irradiation groups with low‐level diode laser 915 nm, 1, 2, 3, 4 J cm−2 and a control group (no Laser irradiation). Cell viability and viability were measured 1, 3 and 5 days after irradiation by MTT and DAPI assay. Statistical differences between groups at any time were analyzed by one‐way ANOVA and a post hoc Turkey’s test. The cell viability and viability capacity increased on the third day at an energy density of 3 J cm−2; (P‐value = 0.007) and the fifth day at energy densities of 2, 3 and 4 J cm−2 was recorded compared with the control group (P‐value = 0.000). Also, a significant decrease in the viability and viability of irradiated cells with an energy density of 1 J cm−2 was found (P‐value = 0.033). According to our results, Photobiomodulation with 915 nm diode laser has a positive stimulating effect on the viability and viability capacity of human gingival fibroblast cells.
Ultraviolet B Irradiation Alters the Level and miR Contents of Exosomes Released by Keratinocytes in Diabetic Condition
Authors: Wang Jinju , Pothana Kartheek , Chen Shuzhen , Sawant Harshal , Travers Jeffrey B. , Bihl Ji , Chen Yanfang 
Published: December 2021

AbstractUltraviolet B (UVB) stimulates the generation of extracellular vesicles, which elicit systemic effects. Here, we studied whether UVB affects the release and microRNA (miR) content of keratinocyte exosomes (EXs) in diabetic conditions. In vitro, we examined the UVB effects on affecting EX release from keratinocyte HaCaT cells (HaCaT‐EX) pretreated with high glucose. HaCaT‐EX functions were evaluated on Schwann cells (SCs). In vivo, UVB‐induced miR change in skin EXs of diabetic db/db mice was analyzed. The miRs of interest were validated in HaCaT‐EXs. We found that: (1) UVB promoted HaCaT‐EX generation in dose‐ and time‐dependent manners; 100 and 1800 J m−2 of UVB had the most prominent effect and were selected as effective low‐ and high‐fluence UVB in vitro. (2) A total of 13 miRs were differentially expressed >3‐fold in skin EXs in UVB‐treated db/db mice; miR‐126 was the most up‐regulated by low‐fluence UVB. (3) Functional studies revealed that the SC viability was improved by low‐fluence UVB HaCaT‐EXs, while worsened by high‐fluence UVB HaCaT‐EXs. (4) MiR‐126 inhibitor attenuated the effects induced by low‐fluence UVB HaCaT‐EXs. Our data have demonstrated that low‐ and high‐fluence UVBs promote HaCaT‐EX generation but differentially affect exosomal miR levels and functions under diabetic conditions.
Concurrent semantic priming and lexical interference for close semantic relations in blocked‐cyclic picture naming: Electrophysiological signatures
Authors: Lin Hsin‐Pei , Kuhlen Anna K. , Melinger Alissa , Aristei Sabrina , Abdel Rahman Rasha 
Published: December 2021

AbstractIn the present study, we employed event‐related brain potentials to investigate the effects of semantic similarity on different planning stages during language production. We manipulated semantic similarity by controlling feature overlap within taxonomical hierarchies. In a blocked‐cyclic naming task, participants named pictures in repeated cycles, blocked in semantically close, distant, or unrelated conditions. Only closely related items, but not distantly related items, induced semantic blocking effects. In the first presentation cycle, naming was facilitated, and amplitude modulations in the N1 component around 140–180 ms post‐stimulus onset predicted this behavioral facilitation. In contrast, in later cycles, naming was delayed, and a negative‐going posterior amplitude modulation around 250–350 ms post‐stimulus onset predicted this interference. These findings indicate easier object recognition or identification underlying initial facilitation and increased difficulties during lexical selection. The N1 modulation was reduced but persisted in later cycles in which interference dominated, and the posterior negativity was also present in cycle 1 in which facilitation dominated, demonstrating concurrent effects of conceptual priming and lexical interference in all naming cycles. Our assumptions about the functional role these two opposing forces play in producing semantic context effects are further supported by the finding that the joint modulation of these two ERPs on naming latency exclusively emerged when naming closely related, but not unrelated items. The current findings demonstrate that close relations, but not distant taxonomic relations, induce stronger semantic blocking effects, and that temporally overlapping electrophysiological signatures reflect a trade‐off between facilitatory priming and interfering lexical competition.
Viruses, friends, and foes: The case of Torque Teno Virus and the net state of immunosuppression
Authors: Redondo Natalia , Navarro David , Aguado José María , Fernández‐Ruiz Mario 
Published: December 2021

AbstractNew reliable biomarkers are needed to improve individual risk assessment for post‐transplant infection, acute graft rejection and other immune‐related complications after solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo‐HSCT). One promising strategy relies on the monitoring of replication kinetics of virome components as functional surrogate for the net state of immunosuppression. Torque Teno Virus (TTV) is a small, non‐enveloped, circular, single‐stranded DNA anellovirus with no attributable pathological effects. A major component of the human blood virome, TTV exhibits various features that facilitate its application as immune biomarker: high prevalence rates, nearly ubiquitous distribution, stable viral loads with little intra‐individual variability, insensitivity to antiviral drugs, and availability of commercial PCR assays for DNA quantification. The present review summarizes the available studies supporting the use of post‐transplant TTV viremia to predict patient and graft outcomes after SOT and allo‐HSCT. Taken together, this evidence suggests that high or increasing TTV DNA levels precede the occurrence of infectious complications in the SOT setting, whereas low or decreasing viral loads are associated with the development of acute rejection. The interpretation in allo‐HSCT recipients is further complicated by complex interplay with the underlying disease, conditioning regimen, and timing of recovery of lymphocyte counts, although TTV kinetics may act as a marker of immunological reconstitution at the early post‐transplant period. The standardization of PCR methods and reporting units for TTV DNAemia and the results from ongoing interventional trials evaluating a TTV load‐guided strategy to adjust immunosuppressive therapy are achievements expected in the coming years.
Breakthrough COVID‐19 after SARS‐CoV‐2 vaccination in solid organ transplant recipients: An analysis of symptomatic cases and monoclonal antibody therapy
Authors: Yetmar Zachary A. , Bhaimia Eric , Bierle Dennis M. , Ganesh Ravindra , Razonable Raymund R. 
Published: December 2021

AbstractBackgroundSolid organ transplant (SOT) recipients are at increased risk for complications from SARS‐CoV‐2 infection. Little is known regarding clinical course and outcomes of breakthrough COVID‐19 in the fully vaccinated SOT population. We sought to describe our cohort of SOT recipients who developed symptomatic breakthrough COVID‐19 after full vaccination.MethodsWe conducted a retrospective review of SOT recipients diagnosed with COVID‐19 at least 14 days after completing SARS‐CoV‐2 vaccination. Patients were analyzed according to those presenting with mild‐to‐moderate and severe COVID‐19, respectively. We described presenting characteristics, COVID‐19 therapy, and analyzed outcomes including emergency department (ED) visits, hospitalization, and intensive care unit (ICU) admission.ResultsThirty‐five patients met inclusion criteria. These had a mean age of 60.8 years and kidney transplant was the most common SOT type. Five patients presented with severe COVID‐19 at diagnosis, all requiring hospitalization without ICU admission. From the 30 patients who presented with mild‐to‐moderate infection, 28 received casirivimab–imdevimab. Four of these 28 (14.3%) had an ED visit, with one requiring hospital admission (3.4%). No patients required ICU admission.ConclusionBreakthrough COVID‐19 may occur in SOT recipients after full vaccination, though they appear to have acceptable outcomes. Anti‐spike monoclonal antibody therapy for eligible SOT patients may have mitigated clinical progression and improved the outcomes. Further study with large cohorts is warranted.
Mapping the empirical evidence on patient involvement interventions in patients with end-stage kidney disease making end-of-life care decisions: a scoping review protocol
Authors: Buur Louise Engelbrecht , Finderup Jeanette , Søndergaard Henning , Kannegaard Michell , Madsen Jens Kristian , Bekker Hilary Louise 
Published: December 2021

ABSTRACT

Objective:
The objective of this scoping review is to investigate and map existing empirical evidence on patient involvement interventions helping patients with end-stage kidney disease to make end-of-life care decisions about kidney services.

Introduction:
Patients with end-stage kidney disease have a high disease burden and mortality rate. Despite this, kidney services differ in how they offer and integrate end-of-life care, if it is offered at all. Some countries have established advance care planning protocols to encourage patient involvement when offering end-of-life care options as part of end-stage kidney disease care. However, there is a limited understanding of the components of patient involvement interventions designed to support patients with end-stage kidney disease making decisions about end-of-life care.

Inclusion criteria:
The review will consider studies on patient involvement interventions concerning end-of-life care decisions for patients with end-stage kidney disease. A broad definition of patient involvement interventions will be used. Studies on interventions that do not involve patients or relatives will be excluded. The review will focus on interventions applied to kidney health care and other services, such as community-based health care.

Methods:
MEDLINE, Embase, Scopus, and CINAHL will be searched. The literature will be screened for inclusion by two independent reviewers. Data synthesis will be conducted through relational analysis investigating patient involvement interventions and relevant information in line with the review objective and questions. Data will be extracted and listed in the data extraction instruments, accompanied by a narrative summary describing how the results relate to the review objective.
Impact of Precompetitive Training on Metabolites in Modern Pentathletes
Authors: Loureiro Luiz L. , Ferreira Tathiany J. , da Costa Camila S.C. , Fidalgo Tatiana K.S. , Valente Ana Paula , Pierucci Anna Paola T.R. 
Published: December 2021

Purpose: Modern pentathlon is a multidisciplinary sport that involves exhaustive training which can cause tissue damage and metabolic changes. However, few studies have evaluated the metabolic changes that occur in pentathletes. Accordingly, we aimed to evaluate the metabolomic profile of pentathletes during a 3-week training period before competition using nuclear magnetic resonance. Methods: Blood samples from 6 members of a Brazilian modern pentathlon team were collected at the beginning (Pre1, Pre2, and Pre3) and end (Post1, Post2, and Post3) of each week. Low molecular-weight metabolite profiles were analyzed by nuclear magnetic resonance spectroscopy, and biochemical markers were assessed using enzyme-linked immunosorbent assays. Data were assessed using partial least-squares discriminant analysis and univariate statistical model. Results: Metabolic changes were observed between pre- and postdata of each week and over the 3 weeks before the competition in the partial least-squares discriminant analysis. Creatine kinase concentration increased in the first 2 weeks (P = .045 and P = .039), but there was no difference in the last week (P > .05). Lactate levels increased significantly after training in each week (P < .001). Cortisol levels at Post3 were different from all other time points (P < .05) and the concentrations of peroxides increased over the weeks (P < .05). Among all metabolites, sarcosine showed the greatest differences (P = .004) in the pretraining and posttraining periods of the 3 weeks. Conclusion: Serum analysis of athletes using nuclear magnetic resonance showed metabolic changes depending on the intensity of the training performed each week.
Karate Training Improves Metabolic Health in Overweight and Obese Adolescents: A Randomized Clinical Trial
Authors: de Souza Fabricio , da Silva Luciano Acordi , Ferreira Gisele Santinoni , de Souza Márcia Mendonça Marcos , Bobinski Franciane , Palandi Juliete , Marcon Chaiana Esmeraldino Mendes , Martins Daniel Fernandes , Schuelter-Trevisol Fabiana , Trevisol Daisson José 
Published: December 2021

Purpose: This study evaluated the effects of 12 weeks of karate training on cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Method: Seventy adolescents were randomized into 2 groups: control received nutritional and psychological interventions once a week for 12 weeks, and treatment received nutritional and psychological interventions once a week, plus 3 karate sessions per week, for 12 weeks. The main outcome measure was improvement in cardiometabolic parameters, oxidative stress, and inflammation. Results: After the intervention period, the treatment group showed a reduction in resting heart rate (77.86 [10.89]), high-density lipoprotein cholesterol (40.86 [8.31]), and triglycerides (75.18 [32.29]) and an increase in low-density lipoprotein cholesterol (95.64 [42.53]) in relation to pretraining. Regarding oxidative stress markers, there was a reduction in protein carbonylation (0.07 [0.06]) and nitric oxide (1.39 [1.11]) and an increase in superoxide dismutase (0.68 [0.31]) and glutathione (0.11 [0.08]) compared with pretraining. With respect to inflammation, adiponectin increased (14.54 [5.36]) after the intervention when compared with preintervention. Conclusion: The study concluded that the intervention may improve cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Long-term effects need to be evaluated.
Bioisobutanol as a Promising Feedstock for Production of “Green” Hydrocarbons and Petrochemicals (A Review)
Authors: Dedov A. G. , Karavaev A. A. , Loktev A. S. , Osipov A. K. 
Published: December 2021

Abstract
The existing approaches to bioisobutanol synthesis and commercial production are considered. Ways of using bioisobutanol as a component of motor fuel and as a promising feedstock for the production of “green” hydrocarbons and other petrochemicals that favor the progress of low-carbon economy are discussed. Particular attention is paid to catalytic processes of isobutanol conversion to isobutylene and butenes, aromatic hydrocarbons, C2–С4 olefins, and hydrogen-containing gases. Data on the mechanism of isobutanol transformations on zeolite catalysts are given.
Risks of infection, hospital and ICU admission, and death from COVID-19 in people with asthma: systematic review and meta-analyses
Authors: Otunla Afolarin , Rees Karen , Dennison Paddy , Hobbs Richard , Suklan Jana , Schofield Ella , Gunnell James , Mighiu Alexandra , Hartmann-Boyce Jamie 
Published: December 2021

ObjectivesTo determine if and to what degree asthma may predispose to worse COVID-19 outcomes in order to inform treatment and prevention decisions, including shielding and vaccine prioritisation.DesignSystematic review and meta-analysis.SettingElectronic databases were searched (October 2020) for clinical studies reporting at least one of the following stratified by asthma status: risk of infection with SARS-CoV-2; hospitalisation, intensive care unit (ICU) admission or mortality with COVID-19.ParticipantsAdults and children who tested positive for or were suspected to have COVID-19.Main outcome measuresMain outcome measures were the following stratified by asthma status: risk of infection with SARS-CoV-2; hospitalisation, ICU admission or mortality with COVID-19. We pooled odds ratios (ORs) and presented these with 95% confidence intervals (CI). Certainty was assessed using GRADE (Grading of Recommendations, Assessment, Development and Evaluations).Results30 (n=112 420) studies were included (12 judged high quality, 15 medium, 3 low). Few provided indication of asthma severity. Point estimates indicated reduced risks in people with asthma for all outcomes, but in all cases the evidence was judged to be of very low certainty and 95% CIs all included no difference and the possibility of increased risk (death: OR 0.90, 95% CI 0.72 to 1.13, I2=58%; hospitalisation: OR 0.95, 95% CI 0.71 to 1.26; ICU admission: OR 0.96, 95% CI 0.75 to 1.24). Findings on hospitalisation are also limited by substantial unexplained statistical heterogeneity. Within people with asthma, allergic asthma was associated with less COVID-19 risk and concurrent chronic obstructive pulmonary disease was associated with increased risk. In some studies, corticosteroids were associated with increased risk, but this may reflect increased risk in people with more severe asthma.ConclusionsThough absence of evidence of a clear association between asthma and worse outcomes from COVID-19 should not be interpreted as evidence of absence, the data reviewed indicate that risks from COVID-19 in people with asthma, as a whole, may be less than originally anticipated.
Evaluating the impact of an enhanced triage process on the performance and diagnostic yield of oesophageal physiology studies post COVID-19
Authors: Doyle Rebecca , Bate Sebastian , Devenney Jade , Agwaonye Sophia , Hastings Margaret , Wych Jane , Archbold Sharon , Vasant Dipesh H 
Published: December 2021

ObjectivesThe COVID-19 pandemic significantly impacted on the provision of oesophageal physiology investigations. During the recovery phase, triaging tools were empirically recommended by national bodies for prioritisation of referrals amidst rising waiting lists and reduced capacity. We evaluated the performance of an enhanced triage process (ETP) consisting of telephone triage combined with the hierarchical ‘traffic light system’ recommended in the UK for prioritising oesophageal physiology referrals.DesignIn a cross-sectional study of patients referred for oesophageal physiology studies at a tertiary centre, data were compared between patients who underwent oesophageal physiology studies 6 months prior to the COVID-19 pandemic and those who were investigated within 6 months after service resumption with implementation of the ETP.Outcome measuresAdjusted time from referral to investigation; non-attendance rates; the detection of Chicago Classification (CC) oesophageal motility disorders on oesophageal manometry and severity of acid reflux on 24 hours pH/impedance monitoring.ResultsFollowing service resumption, the ETP reduced non-attendance rates from 9.1% to 2.8% (p=0.021). Use of the ‘traffic light system’ identified a higher proportion of patients with CC oesophageal motility disorders in the ‘amber’ and ‘red’ triage categories, compared with the ‘green’ category (p=0.011). ETP also reduced the time to test for those who were subsequently found to have a major CC oesophageal motility diagnosis compared with those with minor CC disorders and normal motility (p=0.004). The ETP did not affect the yield or timing of acid reflux studies.ConclusionETPs can effectively prioritise patients with oesophageal motility disorders and may therefore have a role beyond the current pandemic.
Peer support for youth suicide prevention: a scoping review protocol
Authors: Hilario Carla T , Kamanzi Joyce , Kennedy Megan , Gilchrist Lisa , Richter Solina 
Published: December 2021

IntroductionYouth suicide is a significant public health priority, and is the second leading cause of death among young people between 15 and 29 years of age. An emerging intervention in suicide prevention programming with youth is peer support. Although increasingly used in other settings, the evidence for peer support interventions in youth suicide prevention remains nascent. This article presents a protocol for a scoping review aimed at systematically mapping the current evidence on peer support for youth suicide prevention.Methods and analysisArksey and O’Malley’s scoping review framework will guide the review methods. The search strategy will be developed with guidance from a health sciences librarian. Multiple databases (Medline, Embase, PsycINFO, Cumulative Index for Nursing and Allied Health Literature) and grey literature will be identified using terms related to peer support and youth suicide prevention. Publication date restrictions will not be applied. All identified records of published literature will be collated and uploaded to a systematic review management software, Covidence, for review and selection. Screening will be completed in duplicate by two reviewers using predefined inclusion and exclusion criteria. Conflicts during screening will be resolved by a third reviewer. The title and abstract screening and full-text review will be completed in Covidence. Two reviewers will complete data extraction from the selected records, using a tailored extraction form. Screening and data extraction will be completed between January and April 2021. A narrative summary will be completed to synthesise key findings as well as contextual information about the use of peer support interventions in youth suicide prevention programming.Ethics and disseminationThe results will be disseminated through a community research report, presentations of findings at relevant conferences and academic publications of the scoping review protocol and results. The data used for this scoping review will be derived from published resources; therefore, ethics approval is not required for this study.