bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphoric Acid: A Key Role in Control of Structure and Properties of Vanadium Phosphorus Oxide Catalysts During Synthesis
Authors: Zhang Ting , Zhang Ruirui , Zhang Yongkang , Xie Zhiqi , Li Yingwei , Wu Hui , Dai Fei , Liu Ruixia 
Published: January 2021

AbstractThe catalytic performance of vanadium phosphorus oxide (VPO) catalysts is closely related to the synthetic conditions of precursors. Herein, the role of phosphoric acid during VPO precursors synthesis process was thoroughly studied by investigating the morphology, crystal phase composition, and surface chemical property of VPO catalysts and their precursors. The H3PO4 concentration, the temperature of reaction system at the time of H3PO4 adding, and H3PO4 adding speed were optimized to prepared efficient VPO catalysts which applied in selective oxidation of n‐butane to produce maleic anhydride (MA). The obtained VPO catalyst by adding 85 % H3PO4 at or above 110 °C with the speed of approximate 1.1 mL/min could exhibit promising catalytic performances, which are 93.8 % of n‐butane conversion and 62.4 % of MA yield at 420 °C. Thus, this study emphasized the role of H3PO4 adding during VPO synthesis process, which is favorable to understand and fabricate the compositional, structural, and morphological properties of VPO catalysts.
A new method to estimate the economic activity supported by offshore wind: A hypothetical extraction study for the United Kingdom
Authors: Allan Grant , Connolly Kevin , McGregor Peter , Ross Andrew G. 
Published: January 2021

AbstractAs well as their role in contributing towards emissions reductions targets, it is increasingly relevant for policymakers to understand the contribution that renewable energy technologies make to the economy. Various methods have been used to quantify impacts, such as job counts, surveys and measures based on economic statistics. Economic modelling approaches on the other hand appear to offer an ability to both provide metrics of interest to policymakers and crucially an understanding of the activities which support that contribution. In this paper, we implement a new method for estimating the activity supported by renewable energy activities; applying a ‘hypothetical extraction’ of offshore wind—to identify the contribution that such activities make to U.K. economic activity, job quality and national emissions. By undertaking the partial extraction of offshore wind from an aggregated input–output (IO) table and then subsequently from one in which we have separated out the offshore wind electricity sector, we highlight the value of more disaggregation and technology‐specific detail in economic accounts. The results from our fullest extraction suggest that in 2010, offshore wind in the United Kingdom supported 10 240 jobs, with 9 in 10 of these jobs either medium or high skill, and contributed £780 million to gross domestic product (GDP). In addition, a significant portion of activity supported by offshore wind is attributable to expansions in capacity rather than operational activities.
Entropy production far from equilibrium in a chiral charged plasma in the presence of external electromagnetic fields
Authors: Cartwright Casey 
Published: January 2021

Abstract
We report on the time evolution of a charged strongly coupled N = 4 SYM plasma with an axial anomaly subjected to strong electromagnetic fields. The evolution of this plasma corresponds to a fully backreacted asymptotically AdS5 solution to the Einstein-Maxwell-Chern-Simons theory. We explore the evolution of the axial current and production of axial charges. As an application we show that after a sufficiently long time both the entropy and the holographic entanglement entropy of a strip-like topology (both parallel to and transverse to the flow of axial current) grow linearly in time.
Cellular sources of TSPO expression in healthy and diseased brain
Authors: Nutma Erik , Ceyzériat Kelly , Amor Sandra , Tsartsalis Stergios , Millet Philippe , Owen David R. , Papadopoulos Vassilios , Tournier Benjamin B. 
Published: January 2021

AbstractThe 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer mitochondrial membrane. TSPO binding, as measured with positron emission tomography (PET), is considered an in vivo marker of neuroinflammation. Indeed, TSPO expression is altered in neurodegenerative, neuroinflammatory, and neuropsychiatric diseases. In PET studies, the TSPO signal is often viewed as a marker of microglial cell activity. However, there is little evidence in support of a microglia-specific TSPO expression. This review describes the cellular sources and functions of TSPO in animal models of disease and human studies, in health, and in central nervous system diseases. A discussion of methods of analysis and of quantification of TSPO is also presented. Overall, it appears that the alterations of TSPO binding, their cellular underpinnings, and the functional significance of such alterations depend on many factors, notably the pathology or the animal model under study, the disease stage, and the involved brain regions. Thus, further studies are needed to fully determine how changes in TSPO binding occur at the cellular level with the ultimate goal of revealing potential therapeutic pathways.
Moving from Latent to Manifest Problem: Trajectories Across Scientific and Public Salience of Invasive Alien Species
Authors: Vaas J. , Driessen P. P. J. , Giezen M. , van Laerhoven F. , Wassen M. J. 
Published: January 2021

AbstractWho worries first about an invasive alien species: scientists or the general public, or do both become concerned simultaneously? Taking thirteen invasive alien species in the Netherlands, this article reconstructs the development of their public and scientific salience: the attention they attracted and the knowledge about them. Salience was assessed from the number of publications from 1997 onwards in the LexisNexis newspaper database and Scopus scientific database. Three trajectories were derived for a species to move from being a latent problem with low salience toward a manifest status with high public and scientific salience. In the most common trajectory, scientific salience increased first, followed by an increase in public salience. We probed the merit of this concept of trajectories by examining the action undertaken for a representative species of the trajectories. We assigned each of these three species a code for inertia and inaction based on the content of a hundred newspaper articles and all available government documents. Knowing the scientific and public salience of these species clarifies why the actions to deal with them differed even though from an ecological perspective they warranted similar attention. The typology of public and scientific salience and the problem trajectories developed in this article together offer a structured approach for understanding an invasive alien species and provide pointers for engaging a community in managing that species.
An Innovative National Programme for Comprehensive Chronic Wound Therapy and Its Impact on Treatment Outcomes
Authors: Mitura Kryspin 
Published: January 2021

AbstractBackgroundAlthough the lifetime prevalence of chronic ulcers tends to be approximately 2.2–10 per 1000 population, no systemic solutions for this problem have been implemented in many countries. It is still not fully agreed whether treatment of chronic wounds requires hospitalization, which incurs high costs, or whether the therapy can be carried out entirely in an outpatient setting. Therefore, the aim of this study was to evaluate the 5‐year activity and effectiveness of a national programme for the comprehensive treatment of chronic wounds based on hybrid care for patients. Treatment of nonhealing chronic wounds begins in the hospital, where necessary diagnostic actions are carried out, followed by surgical cleansing of the wound and selection of appropriate dressings. Then, the treatment is continued in the outpatient setting with a continuous patient education. The programme is divided into four subsequent stages. In addition, the present study compared the effectiveness of chronic wound treatment with that in the period before implementation of the programme.MethodsFrom January 2015 to December 2019, 383 patients were treated at a centre for chronic wounds. We analysed the outcomes in 227 individuals with chronic venous ulceration or diabetic foot syndrome.ResultsThe mean wound area at the time of introduction of treatment was 36 cm2 (1–290; SD 34). After three stages of treatment, wounds were completely healed in 139 patients (61.2%), 78 patients with venous ulcers (55.3%) and 61 patients with diabetic foot (70.9%). In an additional 67 cases (29.5%), a significant reduction in wound area and depth was achieved, and the treatment was continued beyond the actual treatment programme. No significant effect was achieved in 21 patients (9.2%). In the group of patients treated without systematic application of the guidelines of the programme, wound healing occurred only in 19 cases (26.8%), reduction in the wound area occurred in 27 patients (38.0%), and lack of any healing progress or even worsening of the wound status was found in the remaining 25 cases (35.2%); these differences were statistically significant (p < 0.001).ConclusionTreatment of chronic wounds based on a systematic dedicated programme using an experienced multidisciplinary team of professionals allows to obtain better results in terms of reduction in wound area and might be an effective procedure. The combination of frequent, scheduled outpatient visits, access to inpatient treatment, and regular education of patients based on a standard form improves treatment outcomes.
Basale Wirkmodelle in der Psychotherapie
Authors: Flückiger Christoph 
Published: January 2021

ZusammenfassungDer Beitrag gibt einen Überblick über verschiedene Ansätze, wie die Wirkungsweise von Psychotherapie erklärt werden kann. Basierend auf dem biopsychosozialen Rahmenmodell postuliert die evidenzbasierte Praxis einen Rahmen des professionellen psychotherapeutischen Handelns. Grundsätzlich haben alle an der Therapie beteiligten Personen aktive Mitwirkung. Allgemeine Wirkfaktoren wie beispielsweise die Bereitschaft der Patient*innen zur Veränderung, die Qualität der gemeinsamen Arbeitsallianz oder die Auseinandersetzung der Therapeut*innen mit systematischem Feedback werden dabei als übergeordnete störungs- und therapieschulenübergreifende Wirkkomponenten verstanden.
Relating model bias and prediction skill in the equatorial Atlantic
Authors: Counillon François , Keenlyside Noel , Toniazzo Thomas , Koseki Shunya , Demissie Teferi , Bethke Ingo , Wang Yiguo 
Published: January 2021

AbstractWe investigate the impact of large climatological biases in the tropical Atlantic on reanalysis and seasonal prediction performance using the Norwegian Climate Prediction Model (NorCPM) in a standard and an anomaly coupled configuration. Anomaly coupling corrects the climatological surface wind and sea surface temperature (SST) fields exchanged between oceanic and atmospheric models, and thereby significantly reduces the climatological model biases of precipitation and SST. NorCPM combines the Norwegian Earth system model with the ensemble Kalman filter and assimilates SST and hydrographic profiles. We perform a reanalysis for the period 1980–2010 and a set of seasonal predictions for the period 1985–2010 with both model configurations. Anomaly coupling improves the accuracy and the reliability of the reanalysis in the tropical Atlantic, because the corrected model enables a dynamical reconstruction that satisfies better the observations and their uncertainty. Anomaly coupling also enhances seasonal prediction skill in the equatorial Atlantic to the level of the best models of the North American multi-model ensemble, while the standard model is among the worst. However, anomaly coupling slightly damps the amplitude of Atlantic Niño and Niña events. The skill enhancements achieved by anomaly coupling are largest for forecast started from August and February. There is strong spring predictability barrier, with little skill in predicting conditions in June. The anomaly coupled system show some skill in predicting the secondary Atlantic Niño-II SST variability that peaks in November–December from August 1st.
Concomitant tricuspid regurgitation severity and its secondary reduction determine long-term prognosis after transcatheter mitral valve edge-to-edge repair
Authors: Geyer Martin , Keller Karsten , Bachmann Kevin , Born Sonja , Tamm Alexander R. , Ruf Tobias Friedrich , Kreidel Felix , Hahad Omar , Petrescu Aniela , Hell Michaela , Beiras-Fernandez Andres , Kornberger Angela , Schulz Eberhard , Münzel Thomas , von Bardeleben Ralph Stephan 
Published: January 2021

Abstract
Background
Concomitant tricuspid regurgitation (TR) is a common finding in mitral regurgitation (MR). Transcatheter repair (TMVR) is a favorable treatment option in patients at elevated surgical risk. To date, evidence on long-term prognosis and the prognostic impact of TR after TMVR is limited.

Methods
Long-term survival data of patients undergoing isolated edge-to-edge repair from June 2010 to March 2018 (combinations with other forms of TMVR or tricuspid valve therapy excluded) were analyzed in a retrospective monocentric study. TR severity was categorized and the impact of TR on survival was analysed.

Results
Overall, 606 patients [46.5% female, 56.4% functional MR (FMR)] were enrolled in this study. TR at baseline was categorized severe/medium/mild/no or trace in 23.2/34.3/36.3/6.3% of the cases. At 30-day follow-up, improvement of at least one TR-grade was documented in 34.9%. Severe TR at baseline was identified as predictor of 1-year survival [65.2% vs. 77.0%, p = 0.030; HR for death 1.68 (95% CI 1.12–2.54), p = 0.013] and in FMR-patients also regarding long-term prognosis [adjusted HR for long-term mortality 1.57 (95% CI 1.00–2.45), p = 0.049]. Missing post-interventional reduction of TR severity was predictive for poor prognosis, especially in the FMR-subgroup [1-year survival: 92.9% vs. 78.3%, p = 0.025; HR for death at 1-year follow-up 3.31 (95% CI 1.15–9.58), p = 0.027]. While BNP levels decreased in both subgroups, TR reduction was associated with improved symptomatic benefit (NYHA-class-reduction 78.6 vs. 65.9%, p = 0.021).

Conclusion
In this large study, both, severe TR at baseline as well as missing secondary reduction were predictive for impaired long-term prognosis, especially in patients with FMR etiology. TR reduction was associated with increased symptomatic benefit.

Graphic abstract
Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions
Authors: Platt Christopher I. , Chéret Jeremy , Paus Ralf 
Published: January 2021

AbstractOrgan culture of microdissected scalp hair follicles (HFs) has become the gold standard for human ex vivo hair research; however, availability is becoming very limited. Although various simplistic “HF-equivalent” in vitro models have been developed to overcome this limitation, they often fail to sufficiently mimic the complex cell–cell and cell–matrix interactions between epithelial and mesenchymal cell populations that underlie the specific growth processes occurring in a native HF. Here, we have attempted to overcome these limitations by developing a novel human hair research model that combines dermal papilla (DP) fibroblasts, cultured as 3-dimensional (3D) spheroids (DPS), with plucked anagen hair shafts (HS). We show that DPS express HF inductivity markers, such as alkaline phosphatase (ALP), versican and noggin, while plucked HSs retain substantial remnants of the anagen hair matrix. When cultured together, DPS adhere to and surround the plucked HS (HS-DPS), and significantly enhance HS expression of the differentiation marker keratin-85 (K85; p < 0.0001), while simultaneously decreasing the percentage of TUNEL + cells in the proximal HS (p = 0.0508). This simple model may offer a physiologically relevant first step toward evaluating HF differentiation in the human anagen hair matrix.
Effectiveness of progesterone-primed ovarian stimulation in assisted reproductive technology: a systematic review and meta-analysis
Authors: Cui Ling , Lin Yonghong , Wang Fang , Chen Chen 
Published: January 2021

Abstract
Purpose
Progestin-primed ovarian stimulation (PPOS) is a new ovarian stimulation protocol that has been used over the last decade to enhance reproductive function. The purpose of this study is to evaluate whether PPOS is as effective as conventional protocols (without GnRHa downregulation).

Method
Search terms included “medroxyprogesterone”, “dydrogesterone”, “progestin-primed ovarian stimulation”, “PPOS”, “oocyte retrieval”, “in vitro fertilization”, “IVF”, “ICSI”, “ART”, and “reproductive”. The selection criteria were nonrandomized studies and randomized controlled studies. For data collection and analysis, the Review Manager software, Newcastle–Ottowa Quality Assessment Scale and GRADE approach were used.

Results
The clinical pregnancy rates were not significantly different in either RCTs or NRCTs [RR 0.96, 95% CI (0.69–1.33), I2 = 71%, P = 0.81]; [RR 0.99, 95% CI (0.83–1.17), I2 = 38%, P = 0.88]. The live birth rates of RCTs and NRCTs did not differ [RCT: RR 1.08, 95% CI (0.74, 1.57), I2 = 66%, P = 0.69; NRCT: OR 1.03 95% CI 0.84–1.26), I2 = 50%, P = 0.79]. The PPOS protocol had a lower rate of OHSS [RR 0.52, 95% CI (0.36–0.75), I2 = 0%, P = 0.0006]. The secondary results showed that compared to the control protocol, the endometrium was thicker [95% CI (0.00–0.78), I2 = 0%, P = 0.05], the number of obtained embryos was higher [95% CI (0.04–0.65), I2 = 17%, P = 0.03] and more hMG was needed [in NRCT: 95% CI (307.44, 572.73), I2 = 0%, P < 0.00001] with the PPOS protocol.

Conclusion
The PPOS protocol produces more obtained embryos and a thicker endometrium than the control protocol, with a lower rate of OHSS and an equal live birth rate. The PPOS protocol could be a safe option as a personalized protocol for infertile patients.

Trial registration
Registration at PROSPERO: CRD42020176577.
Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up
Authors: Nersesjan Vardan , Amiri Moshgan , Lebech Anne-Mette , Roed Casper , Mens Helene , Russell Lene , Fonsmark Lise , Berntsen Marianne , Sigurdsson Sigurdur Thor , Carlsen Jonathan , Langkilde Annika Reynberg , Martens Pernille , Lund Eva Løbner , Hansen Klaus , Jespersen Bo , Folke Marie Norsker , Meden Per , Hejl Anne-Mette , Wamberg Christian , Benros Michael E. , Kondziella Daniel 
Published: January 2021

Abstract
Objective
To systematically describe central (CNS) and peripheral (PNS) nervous system complications in hospitalized COVID-19 patients.

Methods
We conducted a prospective, consecutive, observational study of adult patients from a tertiary referral center with confirmed COVID-19. All patients were screened daily for neurological and neuropsychiatric symptoms during admission and discharge. Three-month follow-up data were collected using electronic health records. We classified complications as caused by SARS-CoV-2 neurotropism, immune-mediated or critical illness-related.

Results
From April to September 2020, we enrolled 61 consecutively admitted COVID-19 patients, 35 (57%) of whom required intensive care (ICU) management for respiratory failure. Forty-one CNS/PNS complications were identified in 28 of 61 (45.9%) patients and were more frequent in ICU compared to non-ICU patients. The most common CNS complication was encephalopathy (n = 19, 31.1%), which was severe in 13 patients (GCS ≤ 12), including 8 with akinetic mutism. Length of ICU admission was independently associated with encephalopathy (OR = 1.22). Other CNS complications included ischemic stroke, a biopsy-proven acute necrotizing encephalitis, and transverse myelitis. The most common PNS complication was critical illness polyneuromyopathy (13.1%), with prolonged ICU stay as independent predictor (OR = 1.14). Treatment-related PNS complications included meralgia paresthetica. Of 41 complications in total, 3 were para/post-infectious, 34 were secondary to critical illness or other causes, and 4 remained unresolved. Cerebrospinal fluid was negative for SARS-CoV-2 RNA in all 5 patients investigated.

Conclusion
CNS and PNS complications were common in hospitalized COVID-19 patients, particularly in the ICU, and often attributable to critical illness. When COVID-19 was the primary cause for neurological disease, no signs of viral neurotropism were detected, but laboratory changes suggested autoimmune-mediated mechanisms.
Prognostic impact of rapid reduction of involved free light chains in multiple myeloma patients under first-line treatment with Bendamustine, Prednisone, and Bortezomib (BPV)
Authors: Holzhey Tanja , Pönisch Wolfram , Wang Song-Yau , Holzvogt Madlen , Holzvogt Bruno , Andrea Marc , Zehrfeld Thomas , Hammerschmidt Doreen , Hoffmann Franz Albert , Becker Cornelia , Schwarzer Andreas , Schwarz Maik , Schönfelder-Fricke Uta , Edelmann Thomas , Braunert Leanthe , Franke Georg-Nikolaus , Jentzsch Madlen , Schwind Sebastian , Bill Markus , Grimm Juliane , Remane Yvonne , Platzbecker Uwe , Scholz Markus 
Published: January 2021

Abstract
Introduction
Light chain involvement is observed in almost every patient (pt) with newly diagnosed multiple myeloma (MM). Owing to a relatively short half-life, rapid reduction in the involved free light chain (iFLC) is of potential prognostic value.

Methods
This retrospective analysis included 92 pts with newly diagnosed MM treated with bendamustine, prednisone, and bortezomib (BPV).

Results
After a median number of two (range 1–5) BPV cycles, the majority of pts (n = 86; 93%) responded with either sCR (n = 21), CR (n = 1), nCR (n = 25), VGPR (n = 20), or PR (n = 19). PFS and OS at 48 months were 39% and 67%, respectively. At baseline, 79 out of 92 pts (86%) had iFLC levels above the upper standard level and an abnormal ratio of involved to uninvolved free light chain ≥ 8. In a subgroup analysis of these pts, we evaluated the prognostic importance of an early reduction of the iFLC during the first two BPV cycles. A reduction ≥ 50% of the iFLC on day 8 of the first cycle was observed in 31 of 69 pts. These pts had a significantly better median PFS of 49 months as compared to 20 months in 38 pts with a lower iFLC reduction (p = 0.002). In contrast, OS did not differ significantly with a 48 months survival of 77% vs 69% (p > 0.05).

Conclusion
These results indicate that a rapid decrease in the iFLC on day 8 is an early prognostic marker for newly diagnosed MM pts undergoing BPV treatment.
On quasisymmetric embeddings of the Brownian map and continuum trees
Authors: Troscheit Sascha 
Published: January 2021

AbstractThe Brownian map is a model of random geometry on the sphere and as such an important object in probability theory and physics. It has been linked to Liouville Quantum Gravity and much research has been devoted to it. One open question asks for a canonical embedding of the Brownian map into the sphere or other, more abstract, metric spaces. Similarly, Liouville Quantum Gravity has been shown to be “equivalent” to the Brownian map but the exact nature of the correspondence (i.e. embedding) is still unknown. In this article we show that any embedding of the Brownian map or continuum random tree into$${{\,\mathrm{\mathbb {R}}\,}}^d$$Rd,$${{\,\mathrm{\mathbb {S}}\,}}^d$$Sd,$${{\,\mathrm{\mathbb {T}}\,}}^d$$Td, or more generally any doubling metric space, cannot be quasisymmetric. We achieve this with the aid of dimension theory by identifying a metric structure that is invariant under quasisymmetric mappings (such as isometries) and which implies infinite Assouad dimension. We show, using elementary methods, that this structure is almost surely present in the Brownian continuum random tree and the Brownian map. We further show that snowflaking the metric is not sufficient to find an embedding and discuss continuum trees as a tool to studying “fractal functions”.