bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Combination Therapy with Melatonin on the Enzymes of Glutathione System and the Level of Transforming Growth Factor- β1 in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease
Authors: Popov S. S. , Anufrieva E. I. , Kryl’skii E. D. , Verevkin A. N. , Shulgin K. K. 
Published: September 2021

Aim. The aim of the work was to assess the effect of combination therapy with melatonin on the clinical and biochemical parameters of chronic kidney disease (CKD) and type 2 diabetes mellitus (DM), the level of transforming growth factor-β1, lipid profile, activity of the glutathione antioxidant system enzymes and the activity of NADPH-generating enzymes in patients.Materials and methods. The study involved 60 people (19 men and 41 women, average age 65.6 ± 9.3 years) with chronic kidney disease associated with type 2 diabetes. The patients were divided into 2 groups. The first group of patients received basic treatment (n = 30, 8 men and 22 women, mean age 64.1 ± 7.9 years); the second group of participants (n = 30, 11 men and 19 women, mean age 69.0 ± 10.5 years) received 2 mg of melatonin in addition to the basic therapy. The control group consisted of 65 apparently healthy individuals (30 men and 35 women, average age 42.3±17.7 years) with normal indicators of general and biochemical blood tests. In the course of the work, the analysis of clinical and biochemical indicators and lipid profile in blood serum, the level of transforming growth factor-β1 by enzyme immunoassay, the activity of enzymes of the glutathione antioxidant system and NADPH-generating enzymes by the spectrophotometric method were carried out.Results. The use of melatonin additionally with basic treatment compared with standard therapy led to a decrease in proteinuria (p=0.010), hyperglycemia (p=0.019), urea concentration (p=0.043), glycated hemoglobin (p=0.045) and transforming growth factor-β1 levels (p=0.020) in patients with CKD. In addition, the use of this drug led to a changing of the lipid profile, and the activity of glutathione antioxidant system enzymes and NADPH-generating enzymes.Conclusion. The differences observed during the study were apparently caused by the action of melatonin, which has nephroprotective and hypoglycemic properties, the ability to neutralize reactive oxygen species and activate the antioxidant system functioning.
A systematic review of corporate governance and ownership
Authors: Akinto Tola 
Published: September 2021

This study aims to systematically review the key characteristics and issues of corporate governance and ownership (CGO) research and to offer directional suggestions concerning the future of CGO research. The Systematic Assessment Quantitative Technique (SQAT) was used to identify and analyze 65 peer-reviewed CGO articles from six high-quality academic databases. The study covered 2009 to 2019 and there is evidence of a growing number of CGO articles over the number of years covered. Most of the studies have taken place in Asia and Europe, while South America has the lowest number of studies. 98% of CGO research has been empirical in nature, which calls for more conceptual studies to give more understanding of the research area because knowledge is dynamic. The primary focus of the articles has been on firm performance and closely followed by regulatory policies. All the CGO articles adopted the quantitative research method, using mainly critical analysis. However, combining both quantitative and qualitative methods will make future studies more robust and give additional insight into various issues of CGO. Finally, the use of only six databases which although contains high quality, peer-reviewed articles, but not all peer-reviewed CGO articles were in the databases. Future systematic reviews can widen the scope of databases to gain further insight.
Chiapas moderno y mexicano: normalizar el deporte tras la Revolución mexicana, 1910-1940 = Modern and Mexican Chiapas: Normalizing sport after the Mexican Revolution, 1910-1940
Authors: Lisbona Guillén Miguel 
Published: September 2021

A partir de la Revolución mexicana, las instituciones creadas o reorganizadas por los gobiernos posrevolucionarios tienen, entre otros muchos retos, extenderse en lugares físicamente alejados de la capital del poder político, la Ciudad de México. Otro de sus objetivos era construir el discurso sobre la nueva nación que rompía con el pasado y que, entre cuyos objetivos, se encontraba la normalización de la ciudadanía a través de su regeneración física y moral. Normalización donde la educación física y el deporte se convertían en parte de las campañas de higienización social desplegadas por todo el país. De esta manera, el territorio chiapaneco se incorporó a la institucionalización de la Revolución mexicana y, dentro de ese proceso, las actividades físicas se impulsaron e incrementaron desde los gobiernos posrevolucionarios chiapanecos y, también, desde las élites de la sociedad civil, muchas de ellas partícipes de los nuevos gobiernos e instituciones locales chiapanecas. AbstractSince the Mexican Revolution, the institutions created or reorganized by the post-revolutionary governments have, among many other challenges, spread in places physically far from the capital of political power, Mexico City. Another of its objectives was to build the discourse on the new nation that broke with the past and that, among its objectives, was the normalization of citizenship through its physical and moral regeneration. Standardization where physical education and sport became part of the social sanitation campaigns deployed throughout the country. In this way, the territory of Chiapas was incorporated into the institutionalization of the Mexican Revolution and, within that process, physical activities were promoted and increased from the post-revolutionary governments of Chiapas and also, from the elites of civil society, many of them participants of the new governments and local institutions.
Platinum Group Elements in the South Transbaikalian Basanites (First Data)
Authors: Medvedev A.Ya. , Karimov A.A. , Belyaev V.A. 
Published: September 2021

Abstract
—Study of the behavior and distribution of platinum group elements (PGE), along with other data, is necessary for geodynamic reconstructions. There are almost no PGE data for Transbaikalia, one of the large regions of Russia. This work presents the first data on the contents and behavior of PGE in the Cenozoic intraplate alkali basaltoids of southern Transbaikalia. The total PGE contents are 20–40 ppb. The PGE pattern of the studied basanites is similar to those of mafic OIB, including the Hawaiian ones, and rocks of large igneous provinces: tholeiitic basalts of the Siberian Platform and basaltoids of the West Siberian Plate. Based on this similarity and on the intraplate location of the South Transbaikalian basanites, we have concluded that the basanitic melts formed under mantle plume impact.
Genesis and Nd Isotope Composition of Ferromanganese Deposits of the Sea of Okhotsk and the Kuril Island Arc
Authors: Mikhailik P.E. , Vishnevskaya I.A. , Mikhailik E.V. , Blokhin M.G. , Chervyakovskaya M.V. , Rashidov V.A. , Ren X. 
Published: September 2021

Abstract—The Nd isotope composition of ferromanganese deposits (FMD) from the central part of the Sea of Okhotsk and the Kuril island arc has been studied. The results showed that diagenetic samples from the Deryugin Basin have a heterogeneous Nd isotope composition. The positive εNd values here might be both due to the input of a terrigenous impurity and due to diffuse endogenetic element supply. The FMD samples from the Sonne underwater ridge show a εNd value specific to seawater (–3.2). The εNd value of hydrogenetic FMD from Volcano 7.14 is –3.4, which corresponds to the εNd value of the Pacific water. The FMD samples from Volcano 5.5 are characterized by εNd = –2.0. The higher εNd value might be due to a moderate dilution of the hydrothermal fluid by seawater and might also indicate the presence of volcanic fragments in the FMD samples. The highest εNd value (+4.4) has been established for volcaniclastic sandstone saturated with Fe and Mn hydroxides. It points to a mixing of volcanomictic and hydrothermal materials.
Dispersed Gold and Associated Disseminated Mineralization of Leucogranites of the Dukat Ore Field as Indicators of the Generation Conditions of Magmatogene Gold-Bearing Fluids
Authors: Filimonova L.G. , Trubkin N.V. 
Published: September 2021

Abstract
—We present data on dispersed gold and associated disseminated mineralization of leucogranites controlling the location of the Dukat epithermal Au–Ag deposit. The data suggest the formation and burial of small portions of oversaturated gold-bearing fluids in hypabyssal magmatic bodies. The lower (relative to silver) contents of gold in the deposit ores and the high Ag/Au ratios (350–550) are due to the limited occurrence of oxidized gold-bearing fractions of magmatogene fluids. This limitation is explained by the active interaction of late magmatic portions of fluids and the material of the host carbonaceous volcanosedimentary unit and by the formation of an environment favorable for the concentration, migration, and deposition of manganese, silver, and nonferrous-metal compounds.
Mesozoic Intracontinental Orogeny in the Tectonic History of the Kolyvan’– Tomsk Folded Zone (Southern Siberia): a Synthesis of Geological Data and results of Apatite Fission Track Analysis
Authors: Zhimulev F.I. , Vetrov E.V. , Novikov I.S. , Van Ranst G. , Nachtergaele S. , Dokashenko S.A. , De Grave J. 
Published: September 2021

Abstract
—The Kolyvan’–Tomsk folded zone (KTFZ) is a late Permian collisional orogen in the northwestern section of the Central Asian Orogenic Belt. The Mesozoic history of the KTFZ area includes Late Triassic–Early Jurassic and Late Jurassic–Early Cretaceous orogenic events. The earlier event produced narrow deep half-ramp basins filled with Early–Middle Jurassic molasse south of the KTFZ, and the later activity rejuvenated the Tomsk thrust fault, whereby the KTFZ Paleozoic rocks were thrust over the Early–Middle Jurassic basin sediments. The Mesozoic orogenic events induced erosion and the ensuing exposure of granitoids (Barlak complex) that were emplaced in a within-plate context after the Permian collisional orogeny. Both events were most likely associated with ocean closure, i.e., the Paleothetys Ocean in the Late Triassic–Early Jurassic and the Mongol–Okhotsk Ocean in the Late Jurassic–Early Cretaceous. The apatite fission track (AFT) ages of granitoids from the Ob’ complex in the KTFZ range between ~120 and 100 Ma (the Aptian and the Albian). The rocks with Early Cretaceous AFT ages were exhumed as a result of denudation and peneplanation of the Early Cretaceous orogeny, which produced a vast Late Cretaceous–Paleogene planation surface. The tectonic pattern of the two orogenic events, although being different in details, generally inherited the late Paleozoic primary collisional structure of the Kolyvan’–Tomsk zone.
Statistical Guarantee of Timeliness in Networks of IoT Devices
Authors: Franco Antonio , Landfeldt Bjorn , Körner Ulf , Nyberg Christian 
Published: September 2021

Abstract
The Internet of Things (IoT) paradigm, has opened up the possibility of using the ubiquity of small devices to route information without the necessity of being connected to a Wide Area Network (WAN). Use cases of IoT devices sending updates that are routed and delivered by other IoT devices have been proposed in the literature. In this paper we focus on receivers only interested in the freshest updates from the sending device. In particular, the dynamic network created by routing/gossiping through small devices creates the possibility of delivering updates out of order. Thus, the entire process can be studied well through a queueing system with infinitely many servers, all serving updates with a random service time. Age of Information (AoI) was proposed as the main metric to measure information freshness. We study the amount of time that the AoI is over a certain threshold at the receiver end as a Quality of Service (QoS) measure, called update outage probability. Particularly, given the recent interest in the literature for time domain analysis of the AoI, we obtain the exact expressions for the AoI, peak AoI (pAoI), effective service time and effective departure time distributions for an M/M/$\infty$ queuing system from a time domain perspective, and study the interdependence between the various parameters involved in order to satisfy a given statistical constraint on timeliness.
The Effect of Tribulus Terrestris Supplementation on Inflammation, Oxidative Stress and Performance of Recreational Runners: Study Protocol for a Double-Blind Randomized Controlled Trial
Authors: Nejati Marzieh , Dehghan Parvin , Khani Mostapha 
Published: September 2021

Abstract
Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIOS), exercise-induced muscle damage (EIMD), and inflammation, which are the influencing factors on muscle soreness, localized swelling, and sport performance. Therefore, the purpose of this study is to determine the effectiveness of Tribulus terrestris (TT) as an herbal supplement with antioxidant and anti-inflammatory properties on the nutritional, oxidative stress, and anti/inflammatory status, as well as the sport performance of recreational runners.Methods/design: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners of Tabriz stadiums, Iran. Thirty-four recreational runners will be selected, and participants will be assigned randomly to two groups: to receive 500 mg TT supplement or placebo capsules twice daily for two weeks. Both groups will do the high-intensity interval training (HIIT) workouts during the study. Baseline and post-intervention body composition, muscle fatigue, and soreness parameters will be assessed. In addition, assessment of malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), creatine kinase (CK), lactate dehydrogenase (LDH), insulin-like growth factor-1 (IGF-1) and brain-derived neurotrophic factor (BDNF) will be done during three blood samplings.Discussion: This study will be the first to assess the potential effects of TT in recreational runners. Our results will contribute to the growing body of knowledge regarding TT supplementation on the nutritional, oxidative stress, anti/inflammatory status and sport performance in recreational runners.Trial registration: Iranian Registry of Clinical Trials (www.irct.ir) (ID: IRCT20150205020965N8). Registration date: 13 February 2021.
Identifcation of The Ferroptosis-Related Gene Signature In Placenta of Patients With Early-Onset Preeclampsia
Authors: Yang Nana , Wang Qianghua , Ding Biao , Gong Yinging , Wu Yue , Sun Junpei , Wang Xuegu , Liu Lei , Zhang Feng , Du Danli , Li Xiang 
Published: September 2021

Abstract
Background: The accumulation of ROS resulting from upregulated levels of oxidative stress is commonly implicated in preeclampsia (PE). Ferroptosis is a novel form of iron-dependent cell death instigated by lipid peroxidation likely plays important role in PE pathogenesis. This study aims to investigate expression profiles and functions of the ferroptosis-related genes (FRGs) in early- and late-onset preeclampsia.Methods: The gene expression data and clinical information were downloaded from GEO database. The “limma” R package was used for screening differentially expressed genes. GO(Gene Ontology), Kyoto Encyclopedia of Genes and Genomes(KEGG) and protein protein interaction (PPI) network analyses were conducted to investigate the bioinformatics functions and molecular interactions of significantly different FRGs. Quantitative real-time reverse transcriptase PCR was used to verify the expression of hub FRGs in PE.Results: A total number of 4,215 DEGs were identified between EOPE and preterm cases and 3,356 DEGs were found between EOPE and LOPE subtypes. 20 significantly different FRGs were identified in EOPE, while only 3 in LOPE. Functional enrichment analysis revealed that the differentially expressed FRGs was mainly involved in EOPE and enriched in hypoxia- and iron-related pathways, such as response to hypoxia, iron homeostasis and iron ion binding process. The PPI network analysis and verification by RT-qPCR resulted in the identification of the following six interesting FRGs: FTH1, HIF1A, FTL, IREB2, MAPK8 and PLIN2. Conclusions: EOPE and LOPE owned distinct underlying molecular mechanisms and ferroptosis may be mainly implicated in pathogenesis of EOPE. Further studies are necessary for deeper inquiry into placental ferroptosis and its role in the pathogenesis of EOPE.
Buddhist Monasteries Facilitated Landscape Conservation on the Qinghai-Tibetan Plateau
Authors: Cui Naixin , Wu Tong , Wang Yi-Chen , Zou Huiting , Axmacher Jan Christoph , Sang Weiguo , Guo Luo 
Published: September 2021

Abstract
Context The Sanjiangyuan region of the Qinghai-Tibetan Plateau (also known as the “Three Rivers’ Headwaters”) is the origin of Yellow, Yangtze, and Mekong Rivers and therefore the key water source for hundreds of millions of downstream residents. Protecting this region’s ecosystems is a key priority for sustainable development in China and Asia. An important social dimension of Sanjiangyuan is the long-established and widespread presence of Tibetan Buddhism, particularly as manifested in the large number of monasteries throughout the region. However, the influence of cultural, and specifically religious, factors on environmental change remains largely understudied here. Objective We focus on two types of spatial associations - point-point and point-area features - to quantitatively investigate the effects of Buddhist monasteries on LUCC in surrounding landscapes. Methods We conduct a spatially-explicit analysis of Sanjiangyuan for two periods, 1990-2000 and 2010-2015, to identify and quantify the influence of the presence and spatial distributions of Buddhist monasteries on LUCC (or lack therefore, implying landscape conservation) in comparison to village communities that lack monasteries. Results We found a “clustering effect” in which the spatial aggregation of monasteries being highly correlated with the preservation of natural ecosystems, specifically of grasslands and forests. Within monastery buffer zones with radii between 1 and 10 km, 7.13-9.30% more grassland area and 7.14-7.47% more forest area remained around monasteries compared to villages. This contrast decreased with increasing distance to the monastery/village. Overall built-up areas were also much smaller around monasteries than around villages, while unused land was more commonly transformed to forests and grasslands around monasteries.Conclusions These findings strongly support the idea that Buddhist culture, as manifested through its physical institutions and communities, are instrumental in achieving desired landscape conservation outcomes.
Efficacy and Safety of mFOLFOX6 as Perioperative Chemotherapy for Resectable Liver Metastases from Colorectal Cancer: as Case–Control Study
Authors: Wada Takahiro , Katsumata Kenji , Kasahara Kenta , Mazaki Junichi , Shigoka Masatoshi , Kawakita Hideaki , Enomoto Masanobu , Ishizaki Tetsuo , Nagakawa Yuichi , Tsuchida Akihiko 
Published: September 2021

Abstract
Background: Although resection is effective for managing resectable liver metastases from colorectal cancer, the clinical significance of chemotherapy for such metastases has remained undetermined. Therefore, we conducted a phase II trial of perioperative chemotherapy with mFOLFOX6 to examine its efficacy.Methods: A total of 41 patients were examined. The liver resection rate was the primary endpoint, whereas the response rate, adverse events, completion rate, liver injury rate, R0 resection rate, and histological results were the secondary endpoints.Results: Overall, 34 (82.9%) patients underwent liver resection, and 77.4% and 100% had synchronous and metachronous liver metastases, respectively. The seven remaining patients did not undergo resection because of a progressive disease. Moreover, 2, 15, 17, and 7 patients had a complete response, partial response, stable disease, and progressive disease, respectively, which indicated that the response rate was 41.5%. Regarding adverse events, three patients exhibited Grade 3 myelosuppression and one patient had gastrointestinal symptoms. On the basis of histopathological examination, 27, 5, and 2 patients belonged to grades 1a:1b, 2, and 3, respectively. Regarding liver injury, 29.4% had liver sinusoidal injury, whereas 11.7% had steatohepatitis. Meanwhile, all patients underwent postoperative chemotherapy.Conclusions: mFOLFOX6 is safe and yields favorable therapeutic effects. The indication for liver resection after a certain waiting period is clinically significant.Trial registration；UMIN,UMIN000009725,Registered 01/08/2013 ,URL; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000011399
The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and Risk of Type 2 Diabetes Mellitus and Thyroid Cancer
Authors: Lee Su Hyun , Kim Joyce Mary , Lim Young Wook , Kang Youn Seok , Jung Keum Ji , Jee Sun Ha 
Published: September 2021

Abstract
Background and Objectives: Dioxin, classified as a human carcinogen by International Cancer Research Institute, shows inconsistent results on type 2 diabetes mellitus (T2DM) and cancer in epidemiological studies. International Cancer Research Institute classifies dioxin as a human carcinogen, but epidemiological studies of its effects on type 2 diabetes mellitus (T2DM) and cancer show inconsistent results. Therefore, we conducted a Korean population study to ascertain if the blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) is associated with T2DM and thyroid cancer.Methods: Within a nested case-control study, we identified 15 people diagnosed with thyroid cancer, 30 people diagnosed with T2DM, and 55 for control. Due to the 4ml human blood requirement for PCDD/DF and DL-PCB concentrations tests, a total of 500 samples were used in 100 pooling samples. The continuous variable of a pooled sample was calculated as an average value taking into account the blood weight of each sample. The odds ratios (ORs) and 95% confidence interval (95% CI) for determining the association between total dioxins and risk of T2DM and thyroid cancer were estimated using the multivariable logistic regression.Results: The study population included 100 participants from the KCPS-II (median [IQR] baseline age, 54.06 [21.04] years; 48 women). The toxic equivalents of PCDD/DFs showed a significant positive association with T2DM and thyroid cancer, after adjustments for potential confounders (T2DM ORs = 1.23; 95% CI = 1.05-1.43; Thyroid cancer ORs = 1.34; 95% CI = 1.12-1.61). These results showed a stronger association in women than in men.Conclusion: In this study, both T2DM and thyroid cancer appear to be associated with the levels of PCDD/DFs serum. The association between T2DM and levels of PCDD/DFs serum is found in women and not in men. Our findings suggest that further biochemical in vivo research and epidemiologic studies are needed to clarify the nature of the association between dioxins concentrations and diseases.