bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medullary vasomotor center: a modern view of the structure, function and its role in arterial hypertension pathogenesis
Authors: Danukalo M. , Hancheva O. , Melnikova O. , Isachenko M. 
Published: November 2021

The medullary centers of blood pressure regulation have been in the field of vision of both physiologists and doctors for a very long period of time. This is mainly due to the abundance of structures and interstructural interactions in the brain stem, involved in maintaining blood pressure. Advances in research technology open new opportunities these days to look at this problem from a different angle. Moreover, research of medullary centers of blood pressure regulation will make it possible to understand better the mechanisms of persistent increase in blood pressure, which will create the preconditions for the formation of new pathogenetically substantiated therapeutic approaches in the treatment of such a widespread and dangerous pathology as arterial hypertension. Therefore, the aim of this work was to analyze modern views about the structure and composition of the medullary vasomotor center, its functions and its role in the arterial hypertension development. To achieve this goal, the search by keywords: arterial hypertension, baroreflex, NTS, DMN, RVLM, CVLM, CPA, SHR, LC and analysis of scientific articles from the databases of search engines Google Scholar, Web of Science, Pub Med was done. Conclusions: 1. The analysis of literature sources showed that the concept of "medullar vasomotor center" includes a number of brainstem formations, the most studied of which are the structures of the dorsal complex of the vagus nerve (the nucleus of the solitary tract, the dorsal motor nucleus, area postrema), the rostral and caudal ventrolateral regions of medulla, caudal pressor area, noradrenergic structures of the brainstem, in particular the locus coeruleus, as the biggest of them. 2. According to literary sources, arterial hypertension is accompanied by the changes in the morphofunctional state of the above-mentioned structures. The most common mechanisms are violation of the neurotransmitter composition within the structure and the neuroinflammatory process.
The level of physical activity in the lifestyle of physical education students
Authors: Południak Natalia , Rykiel Zuzanna , Pelic Paulina , Szymańska Natalia , Drzewi Dominik , Chrzanowski Michał , Suchowicz Katarzyna , Czerw Piotr , Burakowska Justyna , Skrzek Daria , Rejman Aneta 
Published: November 2021

Subject: The level of physical activity in the lifestyle of physical education students
Introduction: Physical activity is defined as voluntary and spontaneous physical activity practiced during leisure time. Thanks to it, the body can function properly and develop on many levels. It plays an important role in social and physical development, as well as intellectual and emotional development. It finds its place in the fight against civilization diseases, it is also beneficial in resisting many other diseases.

Aim: The aim of the article is to assess the level of physical activity of physical education students of various specializations.

Material and methods: The research was conducted among students of physical education at the University of Rzeszów. 60 people took part in them - 38 women and 22 men aged 19-30. The respondents answered anonymously to 18 closed, single-choice questions.

Results: The majority of students are engaged in physical activity outside a college, and 65% of it is at amateur level activity. The most common reason why respondents take up physical activity is to improve the functional fitness of the body. 58% of the respondents undertook physical activity more than 3 times a week.

Conclusions: Most of the respondents do physical activity outside of their studies. The most common reason for taking up physical activity among the respondents was the improvement of the functional fitness of the body, and the factors influencing the fact that students are physically active were to the greatest extent sports activities

Key words: physical activity; lifestyle; physical education; student.
The results of ultrasound examination of the thyroid gland in children with hypothyroidism
Authors: Sokolnyk Snizhana , Sokolnyk Iryna , Nechytaylo Dmytro , Kolesnik Dmytro , Hinhuliak Mykola , Ostapchuk Valentyna , Loziuk Iryna , Navrata Iryna 
Published: November 2021

Diseases of thyroid gland (TG) rank first among all endocrine pathologies and remain one of the most difficult problems. According to the statistics of Ministry of Health of Ukraine, the prevalence of hypothyroidism in children does not exceed 0.035%. However, the relatively low rate can be explained by the low level of detection and diagnosis of this pathological condition due to the variability and low specificity of its symptoms. More acceptable for practice are methods of ultrasound diagnosis of the thyroid gland and laboratory examination of the content of thyroid-stimulating hormone in the serum.
Aim. To evaluate the results of ultrasound examination of the thyroid gland in children with hypothyroidism.
Methods. The results are based on a survey of 94 children with hypothyroidism living in the Chernivtsi region aged 2 to 10 years. An ultrasound examination of the thyroid gland, determination of the level of thyroid hormones (thyroid stimulating hormone (TSH), free thyroxine (fT4) was performed. Statistical analysis was performed using standard methods using the StatSoft software package © Statistica® 6.0 for Microsoft® Windows XP.
Results. Analysis of the results of the study showed that in 59.6% of cases (56 out of 94) the diagnosis was made by screening for congenital hypothyroidism, and in 40.4% of cases (38 out of 94) the disease was diagnosed outside the screening. According to the results of our ultrasound, it was found that in 29 patients the thyroid tissue was not visualized in a typical place or its total volume was much less than normal. Of these, in 12 individuals, thyroid tissue was not reliably visualized at the site of TG projection, and in 17 cases was hypoplasia. In 65 patients, the TG was in a typical place, and its volume corresponded to the norm on the surface area of the body. In 85 people, regardless of the state of functional activity of the TG had a heterogeneous echostructure of the thyroid parenchyma), in 9 people the echostructure of the thyroid parenchyma was homogeneous. In thyroid hypoplasia, the level of TSH was at lower values (p <0.05) compared with thyroid dystopia.
Conclusion. Sonographic examination of the thyroid gland has a high level of information. In cases of malformations of the thyroid gland there is a more pronounced degree of thyroid insufficiency.
Morphological features of bone tissue regenerates in experimental animals when using osteotropic drugs for recovery bone defects
Authors: Lysokon Yulia , Luchynskyi Mykhailo , Iskiv Mariana 
Published: November 2021

The aim of the study was to determine the effectiveness using of osteotropic drugs for the restoration of bone defects.
Materials and methods. The model experiment was performing on male Wistar rats. The animals has been simulated a bone defect into which was implanted:"mp3 Osteobiol" (1st experimental group - 14 animals), PRP coated with fibrin glue (2nd experimental group - 13 animals) and PRP + "mp3 Osteobiol" (3rd experimental group - 15 animals). The histological material were staining with hematoxylin-eosin (according to Van – Gizon). Microscopic studies were performing on a Leica MDE optical microscope at a magnification of x 100, x 200.
Results. At the 60th day of observation, after implantation of "mp3 OsteoBiol" + PRP, a pronounced growth of fibrous, loose, not quite mature connective tissue was visualized, with the proliferation of giant multinucleated cells, macrophages, osteoblasts and the formation of osteoids. At the end of the experiment (90th day) in the bone regenerates of animals of group III noted the active formation of the newly formed bone lamellar structure, the formation of osteons, the bone marrow canal was filled with bone marrow.
Conclusion. According to histological studies, it was found that our proposed composition, containing "mp3 OsteoBiol" and PRP, accelerated the process of bone regeneration, compared with the groups where the above agents were used alone, without inflammation, with the formation of bone, which has mature in nature.
Postawy pielęgniarek wobec eutanazji
Authors: Orzeł Zbigniew , Kwietniewska Sylwia , Sutryk Mariusz , Niwińska Kamila , Kutnik Blanka , Guz Ewa 
Published: November 2021

Wprowadzenie
Eutanazja jest trudnym tematem moralnym i kontrowersyjnym wśród społeczeństwa, a także wśród osób wykonujących zawody medyczne. Jest tematem unikanym przez społeczeństwo, ale coraz częściej słyszymy o niej. W Polsce na dokonanie eutanazji nie ma powszechnej zgody, jest zabroniona, choć w niektórych krajach chorzy mają do niej prawo. Głównym celem pracy było poznanie opinii i postawy pielęgniarek czynnie pracujących, na temat eutanazji.

Cel
Celem niniejszej pracy było poznanie opinii i postawy respondentów, czyli personelu pielęgniarskiego, na temat eutanazji w badaniach pilotażowych.

Materiał i metody
Do badania zakwalifikowano 106 pielęgniarek zatrudnionego w placówkach zdrowotnych w powiecie krasnostawskim i chełmskim. W pracy została zastosowana metoda sondażu diagnostycznego. Głównym narzędziem badawczym był samodzielnie skonstruowany, autorski kwestionariusz ankiety. Kwestionariusz ankiety poddano ewaluacji. Najpierw oceny dokonali trzej sędziowie kompetentni (lekarze i pielęgniarka), następnie przeprowadzono badania pilotażowe na 10 osobach. Kwestionariusz nie wymagał poprawek. Badań pilotażowych nie włączono do badań głównych. Wszystkie wyniki poddano analizie z wykorzystaniem programu Microsoft Office Excel 2010.

Wyniki
W badaniu wzięło udział 106 osób: 34 kobiety i 72 mężczyzn. Średni wiek ankietowanych wynosił 40 lat. Analiza statystyczna pokazała, że większość respondentów jest przeciwnikami eutanazji i jej legalizacji w Polsce. Istotne różnice wystąpiły na płaszczyźnie zależności pomiędzy czynnikami socjo- demograficznymi warunkującymi postawę wobec eutanazji.

Wnioski
Wyniki przeprowadzonych badań pokazują pewne tendencje i zależności, które należałoby sprawdzić rozszerzając badania w większej grupie osób pracujących, jako pielęgniarze i pielęgniarki.
Abdominal pain syndrome in girls, adolescents and young women with tumor-like formations of the uterine adnexa
Authors: Tuchkina I. , Tuchkina M. , Kiebashvili S. 
Published: November 2021

The article presents the clinical features of the complicated course of tumor-like formations of the uterine adnexa in girls, adolescents and young women. The characteristic symptoms of adnexal torsion are described. Topographic and anatomic features leading to torsion of ovarian cysts and uterine appendages, features of the surgical treatment of patients with complicated adnexal torsion are presented.
The aim was to study the frequency of occurrence of ovarian tumor-like formations and their complicated course in girls, adolescents and young women, improve early diagnosis and develop optimal methods of conserving surgical treatment of this pathology.
Material and methods. The study included 90 girls, adolescents and young women. Patients were divided into three groups. 1 group included 30 young women; the 2nd group consisted of 35 adolescents 13-17 years; 3 group consisted of 25 girls from 2 to 12 years. Diagnostic complex included clinical, special gynecological, comprehensive laboratory, ultrasound (including doppler ultrasound) research, computer and magnetic resonance imaging (if indicated).
Results and discussion. The final diagnosis of “Ovarian cyst” was verified in 46 of 90 patients (51,1 %): group 1 – 26 of 30 (86,6 %), in 2 – 18 of 35 (51,4 %), in 3 - 2 of 25 (8 %). It is established that the torsion of the uterine adnexa was detected in 44 of 90 patients: in 1 group – 13,3% of cases (4 of 30 young women), in 2 group – 48,5 % (17 of 35 adolescents), in 3 group – 92 % (23 of 25 girls). 76 surgeries were performed by laparoscopy with preservation of the ovarian reserve, 12 patients were treated conservatively with final diagnosis “Ovulatory syndrome” and “Retention cyst of the ovary”.
Conclusions. Ovarian cyst as the cause of abdominal pain is significantly more often diagnosed in young reproductive age than in patients of prepubertal and pubertal age. In girls and adolescent girls with symptoms of acute abdomen the torsion of intact uterine adnexa was significantly more common than in adult patients, due to anatomical features of the internal reproductive organs and more a mobile lifestyle inherent in this age group. Optimal treatment of functional ovarian cyst is complex conservative therapy, surgical treatment of ovarian cysts at a young age is conducted under strict indications, treatment of choice is laparoscopy.
Physiotherapy in a patient with colorectal cancer - preoperative management
Authors: Filarecka Agnieszka , Biernacki Maciej , Jęchorek Michał , Dudzic Piotr , Wyląg Joanna , Lisiński Jarosław , Polakowska-Mierzwa Karolina , Nowak Beata , Jabłoński Wiktor , Hozakowski Mateusz 
Published: November 2021

During the surgical treatment of colorectal cancer, whether by laparoscopic or classic open method, the tissues in the abdominal cavity are traumatized. The cuts of the muscle fibers are associated with the disturbance of the tone of the postural muscles. A scar within the abdominal cavity also causes movement limitations in the form of restrictions in the mobility of the spine. The implementation of patient rehabilitation in the form of targeted physiotherapy before the procedure should be an indispensable element of the treatment of colorectal cancer.
The aim of the study is to propose a therapy that uses the spine mobility test to diagnose deficits. The proposed preoperative therapy focuses mainly on improving the parameters of the spine's mobility. The paper presents examples of activities that can be used in therapy before surgery. A review of the available literature and own experience were used for the work.
It can be concluded from the analyzed literature that physiotherapy in oncological patients is not very widespread and is neglected in the treatment process. Patients, by In the literature, before colorectal cancer removal surgery, they are not subjected to physical rehabilitation, which is associated with complications resulting from the course of the procedure.
The process of rehabilitating patients after surgical treatment of colorectal cancer should take place in the pre-operative period. Physiotherapy should take into account the weakening of the muscle strength in the trunk and limitations of mobility caused by age. Rehabilitation should be aimed at restoring functionality.
Morphometric analysis of supraoptic neurons of the rat hypothalamic nuclei under conditions of prolonged illumination
Authors: Bulyk R. , Smetaniuk O. , Bulyk T. , Kryvchanska M. 
Published: November 2021

The article reviews the results of studies of the morphofunctional state of neurons of the supraoptic nuclei of the rat hypothalamus under conditions of different duration of light regime. Under standard light regime in rats, a diurnal rhythm of morphofunctional activity of supraoptic nucleus neurons with maximum activity during daytime (before 2 p.m.) is recorded.
In animals subjected to prolonged light exposure, more pronounced changes in the morphofunctional state of the supraoptic neurons of the hypothalamus at 2 a.m. than at 2 p.m. were established. Thus, the neuronal nucleus area was 94.08 ± 9.55 μm2 and was significantly greater than that in intact animals. The nucleo-cytoplasmic ratio of supraoptic hypothalamic neuron at 2 a.m. was lower than that in intact animals due to a decrease in specific nucleus volume. In comparison with the day period (2 p.m.), before 2 a.m. there was revealed a decrease of the neuron body area of supraoptic nuclei of hypothalamus due to possible decrease of the area of nucleus and nucleolus of cells. This was the reason for the increase in the nucleo-cytoplasmic ratio in the neurons under observation at night, which was 2.51 ± 0.023 units. Constant light regime did not cause inversion of the rhythm of morphofunctional activity of the neurons under study, the maximum values, as in intact animals, occurred in the daytime observation period.
Wychowanie dojrzałego chrześcijanina jako nowego człowieka w Chrystusie według ks. Franciszka Blachnickiego
Authors: Werbiński Ireneusz 
Published: November 2021

Ks. Franciszka Blachnickiego trzeba uznać za naukowca, który jest świadkiem. Świadek to człowiek, u którego jest pełna harmonia między tym, co myśli, co mówi, a jak żyje. Szczególnie dziś, gdy zauważamy upadek autorytetów wychowawczych, świadectwo życia jest ważniejsze od wiedzy, którą wychowawca też przekazuje.
Niniejsze refleksje zostały zatytułowane: Wychowanie dojrzałego chrześcijanina jako nowego człowieka w Chrystusie według ks. Franciszka Blachnickiego. Profesor Antoni Jozafat Nowak w książce Homo novus (Lublin 2002) mówi, że człowiek powinien pozwolić, aby Chrystus wychował (uformował) człowieka na obraz Boga, który został wpisany w struktury osoby ludzkiej w fakcie stworzenia. Dlaczego Chrystus? Św. Jan pisze: „Boga nikt nigdy nie widział. Jednorodzony Bóg [Jezus, przyp. I.W.], który jest w łonie Ojca, On nam Go objawił” (J 1,18). To znaczy, że Chrystus ma największe szanse na to, aby uformować człowieka na obraz Boga.
Wychowanie dojrzałego chrześcijanina w publikacjach ks. Blachnickiego jest bardzo szczegółowo omawiane. W niniejszym artykule skupimy się tylko na sposobach i pomocach w wychowaniu nowego człowieka, na jego osobowości oraz na wzorach osobowych dla nowego człowieka
Canine peripheral blood mononuclear cell-derived B lymphocytes pretreated with lipopolysaccharide enhance the immunomodulatory effect through macrophage polarization
Authors: Jang Hee-Won , An Ju-Hyun , Kim Kyeong Bo , Lee Jeong-Hwa , Oh Ye-In , Park Su-Min , Chae Hyung-Kyu , Youn Hwa-Young 
Published: November 2021

Background
Preconditioning with lipopolysaccharide (LPS) is used to improve the secretion of anti-inflammatory agents in B cells. However, there are only a few studies on canine B cells.

Objective
This study aimed to evaluate the immune regulatory capacity of canine peripheral blood mononuclear cell-derived B cells pretreated with LPS.

Methods
Canine B cells were isolated from canine peripheral blood mononuclear cells, which were obtained from three healthy canine donors. The B cells were preconditioned with LPS, and then cell viability and the expression of the regulatory B cell marker were assessed. Finally, RNA extraction and immunofluorescence analysis were performed.

Results
LPS primed B cells expressed the interleukin (IL)-10 surface marker and immunoregulatory gene expression, such as IL-10, programmed death-ligand 1, and transforming growth factor beta. Macrophages in the inflammatory condition cocultured with primed B cells were found to have significantly down-regulated pro-inflammatory cytokine, such as tumor necrosis factor-α, and up-regulated anti-inflammatory cytokines such as IL-10. Additionally, it was revealed that co-culture with primed B cells re-polarized M1 macrophages to M2 macrophages.

Conclusions
This study revealed that LPS-primed B cells have an anti-inflammatory effect and can re-polarize macrophages, suggesting the possibility of using LPS-primed B cells as a therapeutic agent for its anti-inflammatory effects and immune modulation.
Acute Hepatitis A and Hepatitis B Coinfection
Authors: Hiramoto Brent , Liu Yao , Dara Lily , Zhou Kali 
Published: November 2021

ABSTRACT
Hepatitis A (HAV) has emerged in outbreaks across the United States particularly in at-risk populations such as men who have sex with men, as well as patients with a history of drug use, homelessness, and incarceration. Immunization among these high-risk populations remains underused. In this study, we describe a case of acute HAV and hepatitis B (HBV) coinfection in an MSM patient occurring in the period of these outbreaks. Clinical resolution of acute HAV and HBV coinfection was attained by 5 months from the time of initial hospitalization without viral hepatitis treatment. This case highlights the need for increased awareness of at-risk populations for HAV and HBV infection in promoting guideline-based vaccination efforts.
Terytorialna historia literatury środkowoeuropejskiej jako spuścizny literackiej i kulturowej monarchii Habsburgów
Authors: Németh Vítová Lenka 
Published: November 2021

Martin C. Putna w 2018 roku wydał Obrazy z kulturních dějin Střední Evropy [Obrazy z dziejów kulturowych Europy Środkowej], w których przedstawia spektakularną panoramę wielokulturowości, wielojęzyczności i wielokonfesyjności poszczególnych regionów Europy Środkowej (rozumianej przez niego jako spuścizna kulturowa Austro-Węgier), by naszkicować ich „historie idei” pozwalające na pełniejszą refleksję przeszłości, a tym samym budowanie przyszłości w oparciu o te (zapomniane lub niekiedy wyparte) doświadczenia. Autor poprzez propozycję terytorialnej historii literatury nadaje nowy kierunek obracającej się w zamkniętym kole dyskusji o konstrukcie Europie Środkowej: eseistyczne obrazy – pomimo fragmentaryczności i subiektywności odczytania – są ewidentnie krokiem w stronę traktowania literatury i kultury jako medium pamięci, liczącym na sprawcze oddziaływanie zatrzymanej w nich pamięci (za Astrid Erll genitivus objectivus).
Geht Kirche digital?
Authors: Büsch Andreas 
Published: November 2021

Zusammenfassung
Die Corona-Pandemie hat die Kirche vor große Herausforderungen gestellt: Gottesdienste, Seelsorge und Gemeindeleben mussten plötzlich „irgendwie online“ funktionieren. Damit stellt sich die Frage nach den Möglichkeitsbedingungen nochmal neu: „geht“ Kirche ihrem Wesen und ihren Vollzügen nach digital? Pastoral-theologisch gibt es dazu keine Alternative – und trotz zahlreicher Herausforderungen zeigen die bisherigen Aktivitäten: Kirche „geht“ digital!
Symbiotische Differenz – freikirchliche Gemeindekulturen im Prozess der Digitalisierung
Authors: Schnepper Arndt 
Published: November 2021

Zusammenfassung
Evangelische Freikirchen gelten hinsichtlich ihrer Gemeinde- und Gottesdienstkultur zumeist als technikaffin. Mit der Bezeichnung der „symbiotischen Differenz“ wird zum einen die Nähe der freikirchlichen Gemeindekultur zur Digitaltechnik beschrieben, zum andern aber auch ihre bleibende Distanz. Letztere ist in der ekklesiologischen Überzeugung begründet, dass sich eine Gemeinde vornehmlich in einer Versammlung körperlich anwesender Menschen konstituiert.
Das Alter des masoretischen Sonderguts im Jeremiabuch
Authors: Stipp Hermann-Josef 
Published: November 2021

Zusammenfassung
Die Datierungen des masoretischen Sondergutes im Jeremiabuch variieren zwischen dem späten 6. und dem mittleren 2. Jh. v. Chr. Eine Überprüfung vorliegender Hypothesen zeigt, dass sie zumeist auf kaum tragfähigen Indizien und Argumenten beruhen. Dies gilt ebenfalls für den neueren Versuch, das Jeremiabuch samt seiner masoretischen Sonderlesarten auf sprachgeschichtlichem Weg zu datieren. Zudem ist für das Sondergut, da mehrschichtig, ein gewisses Zeitfenster zu veranschlagen. Die Fortsetzung wird alternative Datierungskriterien benennen, denen zufolge das Korpus überwiegend im 3. Jh. entstand, möglicherweise mit Ausnahme der Verheißung 33,14–26, für die auch ein späteres Datum bis etwa bald nach der Mitte des 2. Jhs. in Betracht kommt.