bluuebunny/crossref_metadata_2025_split huggingface dataset:
Providence and Prudence in Kant’s Theology and Ethics
Authors: Kerimov Khafiz 
Published: December 2024

Abstract
This article seeks to reevaluate Kant’s treatment of prudence in his ethics, challenging prevalent interpretations that relegate prudence in Kant to mere technique (skill). Scattered across Kant’s texts, there are indications that prudence (practical judgment) fulfills an essential function in Kant’s ethics: by negotiating the contingencies of an uncertain world, prudence adapts the moral imperative to mutable circumstances. However, Kant is convinced that despair is inevitable for humans, when confronted with the inherent uncertainty and indifference of the natural world. The only remedy against this despair for Kant is faith in a providential God: Kant introduces reliance on God’s providence to reconcile human practical reason with chance and nature’s capriciousness. The article thus underscores the inseparable link between human prudence and God’s providence for living a moral life in the Kantian sense.
Oxeiptosis gene expression profiling identified TCN1 as a prognostic factor for breast cancer
Authors: Zhu Yutong , Zhang Lingyu , Zeng Di , Zhou Pan , Hu Jinhui 
Published: December 2024

Abstract

Objectives
Oxeiptosis could suppress the progression of breast cancer (BRCA). We aim to identify the prognostic factor associated with BRCA using oxeiptosis gene expression profiling and investigate its role in BRCA.

Methods
We extracted RNA sequencing data and clinical information on BRCA samples from the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases using an oxeiptosis-related gene set. Prognosis-related genes for BRCA were screened from the TCGA dataset using bioinformatics analysis. Subsequently, we constructed a prognostic model for BRCA depending on the expression of this predictive factor and analyzed the associated function. The effects of Transcobalamin 1 (TCN1) on BRCA cell function and H2O2-induced oxeiptosis were validated in vitro.

Results
TCN1 was identified as the most strongly associated factor with BRCA prognosis among the differentially expressed genes in oxeiptosis. Patients with high TCN1 expression demonstrated a better prognosis in BRCA. In BRCA, TCN1 was enriched in response to the oxidative stress pathway. Additionally, TCN1 was associated with the expression of immune checkpoints and gene variations. Compared to normal human breast epithelial cells, TCN1 was downregulated in BRCA cells. Overexpression of TCN1 inhibited the proliferation, migration, and invasion of BRCA cells, and enhanced H2O2-induced oxeiptosis in BRCA cells.

Conclusions
Based on the oxeiptosis gene set, we identified TCN1 as a prognostic factor associated with BRCA. The findings highlight the potential of TCN1 as a therapeutic target and provide valuable insights into the development of personalized treatment strategies for BRCA.
Utilizing slip conditions on transport phenomena of heat energy with dust and tiny nanoparticles over a wedge
Authors: Nazir Umar , Khan Umair , Almujibah Hamad , Gündoğdu Hami 
Published: January 2025

Abstract
The present problem investigates 3D flow over an expanding wedge geometry of a tangent-hyperbolic Casson fluid. A two-phase approach considers a liquid phase and a dusty fluid, while a Darcy–Forchheimer law is used to model this fluid flow to capture motion and heat transfer. The several aspects are based on variable thermal radiation, heat sink effects, and slip conditions applied. A tri-hybrid nanofluid comprising silicon dioxide, copper, and aluminum oxide nanoparticles suspended in ethylene glycol, the base fluid, is incorporated into the analysis. The derivation of nonlinear ordinary differential equations (ODEs) is used to characterize momentum, thermal behavior, and fluid motion under these circumstances. ODEs are formulated using similarity transformations and slip conditions. The finite element approach is employed. It is estimated that the fluid phase on the heat transfer rate and skin friction coefficient is higher than the dusty phase on the Nusselt number and skin friction coefficient. The heat transfer rate for ternary hybrid nanofluid is larger than that for hybrid nanofluid.
Certifications and testing methods for biodegradable plastics
Authors: Lee WooSeok , Kim JaeHyeon , Lee Tai Gyu 
Published: December 2024

Abstract
This paper offers a comprehensive review of previous studies and articles on international standards and certification criteria for biodegradable plastics. It highlights key insights into the biodegradation environment and certification processes for these materials. As various countries and organizations intensify research efforts on biodegradable plastics, certification standards for biodegradability are evolving and expanding. This trend is expected to play a pivotal role in shaping international standards. Nonetheless, several challenges persist, including the absence of universally recognized testing methods, inconsistencies between real-world and laboratory biodegradation conditions, and a lack of clear definitions and standardized criteria. Above all, establishing international standards is critical to advancing biodegradable plastics as a viable alternative to conventional plastics.
Design optimization of a fluidic thrust vectoring system based on coanda effect using meta-models
Authors: Kara Emre , Kurtuluş Dilek Funda 
Published: December 2024

Abstract
In this study, parametric optimization is employed to identify optimal output parameters for physical components of HOMER nozzle type fluidic thrust vectoring (FTV) system. Optimization study is conducted on seven output parameters: moment around upper Coanda surface, MA; performance parameter, PP; thrust vectoring angle, θ
T; total thrust, T; thrust vectoring efficiency, η; axial thrust, Tx; transverse thrust, Ty. 440 case studies in design-of-experiment stage are employed, utilizing a range of meta-models. Genetic-Aggregation meta-model exhibited highest coefficient of determination (R2) among tested meta-models. In response surface optimization stage, six objectives are enforced through use of Multi-Objective-Genetic-Algorithm technique. Subsequently, three optimization candidate points are identified for filtering of output parameters deemed to be of particular importance. Among them, candidate point with geometry-4 and parameter-1 = 39.23 m/s, exhibited the highest values for PP, θ
T, η, and Ty, with 4.78 %, 4.48 %, 7.97 %, and 7.94 % higher values, respectively, compared to the baseline geometry.
Vitamin D Supplementation and Colorectal Cancer Patients Outcomes
Authors: Mulyadi Noeray Pratiwi , Rudiman Reno , Purnama Andriana 
Published: January 2025

Colorectal cancer is the third most encountered malignancy worldwide in 2018. Some earlier studies indicate a significant influence of vitamin D supplementation on the 5-year survival rate and the rate of metastasis progression in colorectal cancer patients. Studies investigating the effects of vitamin D supplementation on the outcomes of colorectal cancer patients are limited in Indonesia. Therefore, a double-blinded Randomized Controlled Trial (RCT) of the effect of vitamin D supplementation on the outcome of colorectal cancer patients was conducted from April 2022 to March 2023 at the digestive surgery outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. In this study, 36 patients received vitamin D and 34 patients received a placebo. Data analysis performed using the multivariate analysis with multiple regression revealed no significant relationship between vitamin D supplementation and colorectal cancer patient outcomes. Furthermore, ANOVA analysis indicated no relationship between the analyzed independent and dependent variables in this study. No relationship was found between vitamin D supplementation and the outcomes of metastasis, mortality, and Karnofsky scores in colorectal cancer patients. Further research with a larger population is still needed to determine the benefits of vitamin D supplementation on the outcomes of colorectal cancer patients.
Aspects of Media Manipulation in Complex Communication Situations
Authors: Kusse Holger , Shakenova Maigul 
Published: December 2024

The article examines the forms of manipulation in complex communication situations, the essential component of which is multidirectionality, i.e. individual communicative acts addressing multiple audiences. Since complex communication situations are multidirected, they involve various participants who are direct interlocutors, moderators, communication observers, etc. The paper discusses the phenomena of the communicative action orientation towards multiple audiences in staged communication and the participation of the manipulated audience in Internet communication. Multidirectional communication is typical for advertising and talk shows. Although the speakers in talk shows address their interlocutors directly, their statements are perceived by the audience in the studio and the TV viewers. This situation can have a manipulative effect since the latter are not aware that they are the intended recipients. In commercials, characters explain the benefits of a product to other participants in the staged communication event. However, the communication is aimed at the TV audience, which is involved in a large-scale manipulation. From the point of view of manipulation theory, questions arise, such as the effects of monitoring communication (passive participation), the extent to which the recipient themself is part of the manipulation and the responsibility of the recipient and participant of communication in a communicative event.
Metodologia para Avaliação da Caminhabilidade em Centros Urbanos
Authors: Carvalho Marcius Fabius Henriques de , Rodrigues Guilherme Kato , Mota Lia Toledo Moreira , Pezzuto Cláudia Cotrim 
Published: December 2024

Rapid urbanization has turned urban mobility into one of the biggest challenges for modern cities. Intense competition for public spaces in downtown areas of medium and large cities leads to accidents, congestion, increased costs and travel time, and environmental pollution caused by individual motorized and public transport. Searching for a contribution to social, economic, and environmental sustainability this work, considering walking as an essential form of mobility in an urban center of developing countries, proposes a methodology for supporting citizens who arrive at the downtown public bus terminal to select the best walking route to reach essential public services places in the city. Three macro indicators are considered in determining the best walking route: The ambiance indicator results from six sub-indicators, representing physical characteristics of the walking space; the Comfort indicator results from two sub-indicators, representing the visual attractiveness and local comfort; and the Safety indicator results from four sub-indicators; representing public and personal sensations of safety. The proposed methodology is based on two steps: the first reduces the twelve sub-indicators of each route segment to three main indicators. In the second step, a multi-objective optimization problem is formulated to determine the best route from the origin point (public urban terminals) to the citizen interest point. The identification of the most suitable downtown walkability areas can assist local authorities in developing improvement strategies for their ambiance, safety, and comfort standards, actions that will contribute to environmental sustainability and providing urban areas with walking spaces that meet the citizen's expectations.
Dinâmica temporal dos usos da terra, atributos físicos e hemerobia do município de Sorocaba (SP)
Authors: Silva Fabio Leandro da , Smith Welber Senteio , Cunha-Santino Marcela Bianchessi da , Bianchini Júnior Irineu , Menezes Denise Balestrero 
Published: December 2024

Monitoring land use and land cover patterns, evaluating physical environmental attributes, and utilizing landscape indicators, such as hemeroby can significantly aid in the planning and preservation of ecosystem services. This study aimed to analyze the temporal dynamics of land use/land cover in the city of Sorocaba (SP) between 2007 and 2017, as well as the characteristics of the physical environment (i.e., slope and hypsometry) and hemeroby, aiming to provide elements for planning. The results showed the predominance of typologies: urbanized area; native vegetation; pasture; and temporary crops. The municipality's area is characterized by a low variation in hypsometric classes and a low slope, which favors territorial occupancy. The predominant levels of hemeroby are euhemerobiotic and metahemerobiotic, both reflecting significant anthropogenic interference, low self-regulation capacity, and an overriding need for human management and technological dependence. Therefore, urban expansion projects should consider the characteristics of the territory and adopt measures that minimize environmental impacts, facilitating the transition of landscape units with high hemeroby to levels with less anthropogenic interference and technological dependence.
Arquitetura dialógica
Authors: Penteado Neto Raul , Lancha Joubert 
Published: January 2025

Este artículo intenta iluminar el diálogo presente en un proyecto de los arquitectos portugueses Aires Mateus. Ensaya y presenta las relaciones entre las más variadas capas competitivas y complementarias existentes en el caso de estudio de la Casa do Barreiro (2012-22), conversión de un almacén abandonado en una casa unifamiliar, diseñada y construida en las afueras de Lisboa, en las orillas del Tajo, en Portugal. El método utilizado para intentar demostrar el supuesto es el de una Visita de Campo, con un levantamiento fotográfico, acompañado y complementado con una breve Reseña Bibliográfica sobre la obra y el estudio y el período abarcado. Este trabajo busca resaltar la complejidad presente en las estrategias utilizadas en el trabajo estudiado y las formas contemporáneas de rehabilitar ruinas, a favor de la reconversión del uso, la perpetuidad y la longevidad de las estructuras preexistentes en la ciudad.
Importancia y beneficios de la actividad física en la juventud: diferencias según género, ocupación y uso de tecnología
Authors: Novoa López Julio Alfonso , De-Juanas Oliva Ángel , Hossein-Mohand Hassan , Díaz-Esterri Jorge 
Published: December 2024

El ocio deportivo en personas jóvenes favorece su bienestar físico, psicológico y mental, refuerza valores personales y sociales y ejerce como factor de protección frente a conductas de riesgo, como es el consumo de drogas y alcohol. Este estudio tuvo como objetivo analizar la valoración de la importancia de la práctica de actividad física y/o deporte y sus beneficios percibidos entre las personas jóvenes de la Ciudad Autónoma de Melilla[1]. Se plantearon objetivos secundarios, como comprender la relación entre las percepciones sobre la importancia de la actividad física y los beneficios psicológicos y sociales, así como evaluar el impacto de variables independientes como el género, la ocupación y el uso de tecnología y redes sociales en dichas valoraciones. Se empleó una metodología no experimental, cuantitativa y transversal, utilizando un diseño descriptivo, correlacional e inferencial. El estudio reclutó una muestra incidental que incluyó a 1.949 jóvenes de entre 18 y 35 años. Se utilizó un cuestionario elaborado ad hoc que fue aplicado como recurso en línea. Los resultados del estudio sugieren que para las personas jóvenes la actividad físico-deportiva tiene una importancia moderadamente alta en sus vidas y en su tiempo libre. Asimismo, la actividad física se percibe también como útil para olvidar problemas y para aumentar la seguridad en sí mismos. Sin embargo, se valora menos como una forma de socialización con amigos. A su vez, los resultados revelan diferencias estadísticamente significativas en cuanto al género, en la valoración de la importancia del deporte, siendo mayor en el género masculino. También se encontraron diferencias estadísticamente significativas en la valoración según la ocupación y el uso de tecnología y redes sociales. Los hallazgos subrayan la necesidad de estrategias inclusivas que consideren las diferencias de género y otros factores para promover la actividad física y el deporte entre las personas jóvenes y maximizar sus beneficios.

[1] Este artículo es parte del proyecto I+D+i, Gestión autorregulada del tiempo en la juventud: ocio, bienestar y apoyos sociales, financiado por el MCIN PID2022-14227OB-I00 y “FEDER Una manera de hacer Europa”. Asimismo, es también resultado del contrato de investigación conveniado por el artículo 60 de la LOSU, titulado “Melilla, Ciudad Social. Estudios sobre el efecto de la COVID-19 en los jóvenes y profesionales de los servicios sociales” entre la UNED con la Consejería de Distritos, Juventud y Participación Ciudadana de la Ciudad de Melilla.
Acercamiento al concepto muerte en las obras de san Juan de la Cruz
Authors: Reina Herrera Edwin Fernando 
Published: December 2024

Este artículo quiere examinar la comprensión del concepto muerte en las obras del místico español Juan de la Cruz. La investigación realiza una mirada panorámica de los usos del término en los escritos del fraile para vislumbrar sus características, partiendo de un acercamiento al contexto histórico que pudo influir en la idea que se formó acerca de ella. Principalmente se recurre a elementos gramaticales, semánticos y teológicos para mostrar el alcance que el autor da a la muerte en la experiencia humana y particularmente en la experiencia espiritual. El artículo también muestra la dualidad entre la vida y la muerte en Juan, así como el doble significado, negativo y positivo, que tiene del término, tanto para hablar de la muerte física, como para hablar de la muerte espiritual y sus particularidades, ya que para él la muerte puede ser sinónimo de vida y objeto del amor.
Redescubriendo la economía sostenible: la gestión de los Institutos religiosos
Authors: Villaluenga De Gracia Susana , Jiménez Montañés Mª Ángela 
Published: December 2024

El Desarrollo Sostenible (DS) o duradero[1] supone satisfacer las necesidades del presente sin comprometer la capacidad de las futuras generaciones para satisfacer las propias[2]. Ello hace que decidir con criterios de sostenibilidad económica vaya más allá de la sostenibilidad medioambiental de la economía con la que habitualmente se relaciona.
Este trabajo pretende ser un modesto intento de explorar la capacidad de sostenibilidad o permanencia de los institutos religiosos a lo largo de la Historia indagando en las claves de su administración y gestión económica.
Del estudio se inferirán como variables de la sostenibilidad económica, entre otras: el sentido de comunidad, la administración y gestión propia, la optimización y gestión racional de los recursos, el uso del presupuesto, la capacidad de autofinanciación, la limitación del endeudamiento, el control interno y el ejercicio efectivo de la responsabilidad.
[1] Existe un matiz entre los significados de ambos términos. Mientras duradero implica actuar al objeto de garantizar la prolongación de unos efectos positivos en el tiempo, operar de forma sostenible significa hacerlo sin comprometer la satisfacción de las necesidades de generaciones futuras.
[2] ONU. Informe Brundtland. New York: ONU Publishing, 1987.
The Idea of Time and the Evolution of History. Thoughts on a Dialectic in Spanish Medieval Judaism
Authors: Fernández López José Antonio 
Published: December 2024

From its origin, Israel has been determined by history. The Jewish people was shaped historically as such around the Torah. However, Jewish history itself witnessed in its bosom the birth of spiritual experiences that go beyond historical and chronological boundaries. Aside from history and temporality, some experiences, paradoxical to its collective existence, appear continuously in Jewish history throughout time. In the present article we will analyze, from the perspective of philosophy and theology of history, this duality in a time and place that are key to its understanding: The Middle Ages in the Iberian Peninsula. Our research is a transversal outlook in which this topic is addressed from a broad analysis ranging from tradition and scripture, to mystique, philosophy and eschatology.
A study on various risk factors involved in benign gastrointestinal perforations in rural population of tri-state border
Authors: Venkatesan Arjun Karthik Muthukrishnan , Amudala Abhiram , Chidamber Rao Channanna , Dasari Kavya 
Published: December 2024

Background: Gastrointestinal perforation is a common surgical emergency encountered by surgeons worldwide. Benign gastrointestinal perforations are especially prevalent in rural populations, leading to significant mortality and often requiring emergency surgery. This study was aimed to investigate the association of various risk factors of benign gastrointestinal perforations in the Tristate border of Tamil Nadu, Andhra Pradesh and Karnataka, thereby assessing the prognosis and surgical outcome.
Methods: A prospective observational study was conducted from March 2023 to March 2024 at the Department of General Surgery, PESIMSR, KUPPAM. The study included a total of 50 patients with perforation features, selected using purposive sampling technique. A detailed medical history was taken, physical examination and relevant investigations were conducted, and the findings were correlated with intraoperative and histopathology reports. The patients were followed up for complications. The data was analysed with appropriate statistical methods.
Results: Out of 50 patients, 72% were males and 28% were females. The most common age range of presentation was 41-50 years. The leading cause of perforation was peptic ulcer, accounting for 46% of cases, followed by appendicitis in 22% of cases, typhoid in 18% of cases, trauma in 12% of cases, and tuberculosis in 2% of cases. Mortality was observed in 7 cases (14%). It's important to note that multiple organ dysfunction syndrome (MODS) and mortality were linked to a higher Mannheim peritonitis prognostic index, indicating a poor prognosis.
Conclusion: Early diagnosis with risk factors assessment, immediate fluid resuscitation, and timely surgical intervention are crucial in significantly lowering the mortality rate associated with perforated peritonitis.