bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement properties of the sit-to-stand test in people with chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis using the COSMIN guidelines
Authors: Farley Christopher , Phillips Stuart M. , Smith-Turchyn Jenna , Brooks Dina 
Published: December 2024

Introduction
Characteristics of chronic obstructive pulmonary disease (COPD) can include shortness of breath, chronic cough, sputum production and reduced exercise capacity. The sit-to-stand (STS) test variations (e.g., 5-repetition STS, 30-second STS) may be appropriate outcome measures to assess exercise capacity in people with COPD. To date, the measurement properties of the various STS tests in people with COPD have not been synthesized in a systematic review since the publication of the COnsensus‐based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. The purpose of this proposed systematic review is to synthesize the literature of the measurement properties of the STS test variations among people with COPD.

Materials and methods
The review will be conducted with methods consistent with the COSMIN guidelines. Peer-reviewed publications will be included if they assessed the measurement properties (reliability, validity, responsiveness) of a STS test in community-dwelling adults with COPD. We will search six databases from inception. Study selection and data extraction will be conducted independently and in duplicate. We will assess the risk of bias using the COSMIN Risk of Bias tool, assess results against the COSMIN updated criteria for good measurement properties, and summarize certainty of evidence using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. Study results will be pooled by calculating weighted means and 95% confidence intervals or summarized narratively, as appropriate.

Conclusion
This will be the first systematic review to synthesize the measurement properties of the STS tests in people with COPD using the methods recommended by COSMIN. Consequently, its results will be robust and may help clinicians or researchers identify the best variation of the STS test to use in their practice.
Identification of markers correlating with mitochondrial function in myocardial infarction by bioinformatics
Authors: Kuang Wenlong , Huang Jianwu , Yang Yulu , Liao Yuhua , Zhou Zihua , Liu Qian , Wu Hailang 
Published: December 2024

Background
Myocardial infarction (MI), one of the most serious cardiovascular diseases, is also affected by altered mitochondrial metabolism and immune status, but their crosstalk is poorly understood. In this paper, we use bioinformatics to explore key targets associated with mitochondrial metabolic function in MI.

Methods
The datasets (GSE775, GSE183272 and GSE236374) were from National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) in conjunction with mitochondrial gene data that were downloaded from the MitoCarta 3.0 database. Differentially expressed genes (DEGs) in the dataset were screened by ClusterGVis, Weighted Gene Co-Expression Network Analysis (WGCNA) and GEO2R, and functional enrichment was performed by Gene Set Enrichment Analysis (GSEA) and Kyoto Encyclopedia of Genomes (KEGG). Then mitochondria-associated DEGs (MitoDEGs) were obtained. Protein-protein interaction (PPI) networks were constructed to identify central MitoDEGs that are strongly associated with MI. The Cytoscape and miRWalk databases were then used to predict the transcription factors and target miRNAs of the central MitoDEG, respectively. Finally, the mouse model has been established to demonstrate the expression of MitoDEGs and their association with cardiac function.

Results
MitoDEGs in MI were mainly involved in mitochondrial function and adenosine triphosphate (ATP) synthesis pathways. The 10 MI-related hub MitoDEGs were then obtained by eight different algorithms. Immunoassays showed a significant increase in monocyte macrophage and T cell infiltration. According to animal experiments, the expression trends of the four hub MitoDEGs (Aco2, Atp5a1, Ndufs3, and Ndufv1) were verified to be consistent with the bioinformatics results.

Conclusion
Our study identified key genes (Aco2, Atp5a1, Ndufs3, and Ndufv1) associated with mitochondrial function in myocardial infarction.
Uncovering Antimicrobial Potential: Analyzing Soil Microbial Diversity and Antibiotic Production at Brackenridge Field Laboratory
Authors: Oseyifunmi Edidioluwa , Moline Laci , Lenton Valencia , Osagie Muna 
Published: December 2024

The global antibiotic crisis is driven by the rapid emergence of bacterial resistance, necessitating innovative approaches to discover novel antibiotics. Soil bacteria, known for producing antibiotics to outcompete neighbors, represent a promising source of antimicrobial compounds. In this study, soil samples from a dry, gravelly area of the Brackenridge Field Laboratory (30.28359°N, -97.77945°W) were analyzed to identify potential antibiotic-producing bacteria. Serial dilutions yielded a microbial density of 123 and 58 CFUs on 10^-1 and 10^-2 plates, respectively. Co-culturing with

E. coli and

E. raffinosus revealed that 18.75% of isolates inhibited

E. coli, while 6.25% inhibited

E. raffinosus.
Isolate 3 exhibited dual resistance to Ampicillin and

E. coli, making it a standout candidate for further investigation. Morphological, physiological, and metabolic characterization revealed diverse traits among isolates, including motility, lactose fermentation, and distinct colony morphologies. PCR confirmed successful DNA amplification in isolates 3 and 4, while Gram staining classified isolates as both Gram-positive and Gram-negative. Metabolic profiling highlighted unique properties, such as catalase activity in isolates 3 and 4 and beta-hemolysis in isolate 4, indicating potential clinical or ecological significance.
Despite limited antibiotic production, the findings highlight the resilience and adaptive capabilities of soil bacteria in arid environments, particularly in nutrient-limited conditions. The study emphasizes the importance of further research into environmental factors influencing antibiotic production and resistance. By exploring the biochemical diversity of soil microbiota, this research contributes to global efforts to mitigate the antibiotic crisis and advance the discovery of novel antimicrobial agents.
Infliximab and adalimumab in the treatment of fistulizing Crohn’s disease: a propensity score-matched analysis from the prospective Persistence Australian National IBD Cohort (PANIC4) study
Authors: Chetwood John David , Paramsothy Sudarshan , Leong Rupert W 
Published: December 2024

Background/Aims:
There are spare data on comparative medication efficacy in fistulizing Crohn's disease (FCD), particularly with immunomodulator co-therapy. Persistence is a unique way to assess real-world outcomes.

Methods:
The persistence of all dispensed biological agents were analysed from the Australian Pharmaceutical Benefits Scheme (PBS) registry data 2005-2021 for FCD. Propensity score matching was performed to account for baseline cohort imbalance.

Results:
There were 5,739 lines of therapy in 4,466 patients over the 16-year period with 17,144 patient-years of follow-up; via therapy 2,605/5,739 (45.4%) used adalimumab and 3,134/5,739 (54.6%) used infliximab; 1,697/5,739 (29.6%) used thiopurine co-therapy at induction, whilst 242/5,739 (4.2%) used methotrexate. As a first-line biologic (biologic-naïve), infliximab showed superior overall- and corticosteroid-free persistence to adalimumab (P=0.0002 and P=0.0021 respectively). Used after first-line (biologic-exposed), there was no difference between agents for overall persistence (P=0.064) though infliximab showed greater corticosteroid-free persistence (P=0.030). Co-induction with thiopurine was associated with improved overall- and corticosteroid-free persistence (P=0.0002 and P=0.045 respectively). After propensity score matching, infliximab showed superior overall and corticosteroid-free persistence compared to adalimumab in bio-naïve (P<0.0001 and P=0.0016 respectively), not in bio-exposed patients (P=0.12 and P=0.074 respectively). Thiopurine was associated with superior overall- and corticosteroid-free persistence use, though no difference was seen with methotrexate.

Conclusion:
The PANIC cohort with real-world data of non-hierarchical prescribing of biological agents supports the superiority of infliximab over adalimumab in bio-naïve FCD patients, but did not show a therapeutic difference in bio-exposed FCD. Thiopurine co-therapy was independently associated with improved biological agent persistence in FCD.
Noninvasive Assessment of Vascular Endothelial Growth Factor and Prognosis in Gastric Cancer Through Radiomic Features
Authors: Feng Hao , Zhou Kangneng , Yuan Qingyu , Liu Zhiwei , Zhang Taojun , Chen Hao , Xu Benjamin , Sun Zepang , Han Zhen , Liu Hao , Yu Shitong , Chen Tao , Li Guoxin , Zhou Wenlan , Yu Jiang , Huang Weicai , Jiang Yuming 
Published: December 2024

INTRODUCTION:
Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with delayed diagnosis often limiting effective treatment options. This study introduces a novel, noninvasive radiomics-based approach using [18F] FDG PET/CT (fluorodeoxyglucose positron emission tomography/computed tomography) to predict vascular endothelial growth factor (VEGF) status and survival in patients with GC. The ability to noninvasively assess these parameters can significantly influence therapeutic decisions and outcomes.

METHODS:
We conducted a retrospective study involving patients diagnosed with GC, stratified into training, validation, and test groups. Each patient underwent a [18F] FDG PET/CT scan, and radiomic features were extracted using dedicated software. A Radiomics Score (RS) was calculated, serving as a predictor for VEGF status. Statistical analyses included logistic regression and Cox proportional hazards models to evaluate the predictive power of RS on survival outcomes.

RESULTS:
The developed radiomics model demonstrated high predictive accuracy, with the RS formula achieving an area under the receiver operating characteristic curve of 0.861 in the training cohort and 0.857 in the validation cohort for predicting VEGF status. The model also identified RS as an independent prognostic factor for survival, where higher RS values correlated with poorer survival rates.

DISCUSSION:
The findings underscore the potential of [18F] FDG PET/CT radiomics in transforming the management of GC by providing a noninvasive means to assess tumor aggressiveness and prognosis through VEGF status. This model could facilitate earlier and more tailored therapeutic interventions, potentially improving survival outcomes in a disease marked by typically late diagnosis and limited treatment success.
Perceived Individual Team Member Value Creation in In-Class Permanent Teams. Analysis of evidence from individual peer reviews in a Team-Lecture Hybrid instructional strategy.
Authors: Tataw David 
Published: December 2024

This study analyzes individual peer review assessment data in order to understand the following: contributions of individual team members to in-class permanent team outcomes; social loafing and loss of social interdependence among team members; and the achievement of the Team Lecture Hybrid(TLH) instructional strategy learning outcomes in a team learning environment. A value creation theoretical framework was used to assess perceived value creation in 952 statements recorded in 341 intra-group assessment narratives from 127 students in 28 in-class permanent teams across 11 courses. Participants were drawn from public affairs, leadership, and healthcare administration courses, in two US institutions of higher learning from January 2012 to May 2016. Fifteen emerging themes organized under four predetermined domains including preparednesss (14.3%), contribution to productivity (53.4%), respect for others (13.8%), and flexibility (18.1%; and one emergent domain including teacher contribution (1.15%); revealed the following about individual performance: 1. either added to, or subtracted from collective team performance; 2. were empirically aligned with four value creation cycles in the value creation conceptual framework; and 3. advanced four expected student learning outcomes. Social loafing and loss of social interdependence was identified in team member interactions and they interfere with student learning outcomes. Permanent team members desired and expected the following five attributes from their team members: 1. to be prepared for project activities; 2. to contribute substantially or intangibly to team productivity by sharing knowledge, having good work habits, improving the team product, and helping with leadership and coordination; 3. to be respectful of others;4. to seek consensus and comprise; and 5. to show flexibility in their interaction with others They also see their teacher as an intangible resource in the permanent team who provides knowledge, moral leadership, structure, and mentoring. Instructors and student should consider these findings when they participate or facilitate learning activities in in-class permanent teams.
Association of Comorbidities and Levels of Depression among Pre-elderly with HIV in DKI Jakarta
Authors: Suta Ni Wayan Mutiara Suasti , Surilena Surilena , Agus Dharmady , Suryani Eva 
Published: December 2024

Background: The presence of comorbidities in pre-elderly with HIV can worsen the disease symptoms, and disabilities, and lead to the emergence of depressive symptoms. Depression in the pre-elderly can cause a decrease in quality of life and failure to achieve successful aging. This study aims to determine the association between comorbidities and the level of depression among pre-elderly with HIV. Method: This is an observational analytic study with a cross-sectional method using a characteristic questionnaire (age, gender, education level, occupation, economic status, and marital status), comorbidities questionnaire, and PHQ-9 questionnaire. This study used convenience sampling and obtained 161 pre-elderly respondents (45—59 years) with HIV among pre-elderly with HIV in DKI Jakarta. The data analysis was done using the Fisher Exact test using STATA. Result: There were 161 pre-elderly with HIV, 74,16% were men, 55,28% were in Senior High School, 72,67% were working, 76,4% had low economic status, and 44,72% were not married. A total of 59,85% have one comorbid condition. There were 81,37% with physical comorbidities, including 40,82% arthritis, 38,27% hypertension, 6,63% diabetes mellitus, and 51,55% with depression including 27,95% mild depression, 16,15% moderate depression, 5,59% moderate severe depression, and 1,86% severe depression. No significant association was found between comorbidities and the levels of depression among pre-elderly with HIV (p=0,341). The presence of physical comorbidities in pre-elderly with HIV can affect the disease progression and its treatment. However, in this study, There is no significant association between comorbidities and the levels of depression among pre-elderly with HIV in DKI Jakarta. It is recommended that further research be conducted using in-depth interviews to explore the relationship between physical comorbidities and depression in pre-elderly with HIV.
Plato, Republic Book II and Antiphon’s On Truth
Authors: Lea Luke 
Published: December 2024

Abstract
Scholars have long been aware of striking similarities between a crucial passage in Book II of Plato’s Republic and the longest papyrus fragment surviving from Antiphon’s On Truth. Previous scholarship has identified some views common to both texts but has not explained how these views hang together in a unified and coherent ethical outlook. A deeper investigation into these two texts turns up a blueprint for Greek immoralist arguments, a finding which should be of considerable interest to scholars of ancient Greek ethics and political philosophy. The paper argues that both texts include an argument whose demonstrandum is that it is by nature good or advantageous to commit injustice when one can do so undetected; that this argument in each case involves a set of background premises that constitute a blueprint for immoralist arguments in Classical Athens; and that the immoralist ethical theory of Republic II is an outline distilled from several more detailed theories, including the one belonging to On Truth.
China’s Dual Structure-Based Growth Accounting—Theoretical and Empirical Analysis of Introducing the Labor Employment Rate
Authors: Zhao Wen 
Published: December 2024

Abstract
The role of the dual structure in economic growth is often weakened by the use of neoclassical growth models, resulting in the defect of strong theoretical but weak empirical evidence. We take the labor employment rate as an abstract attribute of the dual stage and construct a growth accounting equation that can conduct unified growth accounting among economies at different stages of development and among different stages of development of the same economy. On this basis, we measured the potential contribution of increasing the labor employment rate to economic growth in the future. The results show that the elimination of the dual structure will continue to be an important source of China’s medium and long term economic growth.
The Growth Contribution of China’s Regional Coordinated Development Strategy—On the Dispute of Regional Policy Paths
Authors: Nian Meng , Zhang Haipeng , Wang Yao 
Published: December 2024

Abstract
Balancing macroeconomic growth with regional equilibrium development is essential for China’s pursuit of the modernization through regional coordinated development. Taking a macroeconomic output perspective and employing a counterfactual framework, this paper evaluates the economic growth effects of China’s “place-based” and “people-based” regional policies, and explores the future implementation effects and optimal combinations of these policies under different market environments. Given that “people-based” policy cannot address market failures in spatial dimensions, the essence of the academic debate over regional policy paths lies in different understandings of the relationship between government and markets.
New Production Relations Driven by New Quality Productive Forces: Trends, Challenges and Countermeasures
Authors: Liu Zhibiao 
Published: December 2024

Abstract
Under the wave of the fourth industrial revolution, the development of new quality productive forces represented by intelligent technology will shape the form, structure and nature of new production relations, such as the reduction of the coordination status of human-human relations and the increasing importance of the coordination of human-machine relations. There will be a fundamental revolution in ownership relations, the form of enterprise organization, the way in which they are distributed and the structure of management. The assumptions, logic, and paradigms of economics that are compatible with the first three industrial revolutions will encounter great challenges. To this end, it is necessary to comprehensively deepen the reform of the actual economic system and promptly adjust the capital system, industrial policy, employment and distribution policy, market policy, education policy, science and technology policy, and talent policy that are not suitable for the development of new quality productive forces.
The Theoretical Gap in the Study of New Quality Productive Forces and the Economic Analytical Perspective of “Heterogeneity”
Authors: He Jun 
Published: December 2024

Abstract
Economic studies on the new quality productive forces NQPF are mushrooming, however, on the whole, the majority of existing studies primarily focus on revealing and summarizing the economic laws guiding the development of NQPF based on the“general”characteristics of individual organizations at the microlevel and institutions at the macro level. This paper argues that the background of “getting great” and the competition scenario between countries determine that “heterogeneity” is the most relevant and theoretically challenging issue in the NQPF, and also the most likely to yield significant academic outcomes. In view of the fact that the existing problem setting, conceptual framework, and analytical tools of existing eccomics fail to effectively address the unique prescriptive phenomena of NQPF, including direct competition between countries, power countries, and heterogeneity, future academic research on new quality productive forces should go beyond the current “general” issues orientation, directly address the extreme phenomena and problems in the “genesis” stage in the latest round of scientific and technological revolution, and strive to push forward the frontiers of theoretical research.
Functional Upgrading of Value Chains and the Carbon Emissions Reduction Embodied in China’s Exports: From the Perspective of the Improvement in the FDI Quality
Authors: Chen Fuzhong , Luo Ke , Dong Kangyin 
Published: December 2024

Abstract
Improving the quality of foreign investment to help functional upgrading of the value chain is an important starting point for China’s manufacturing industry to achieve low-carbon and high-quality development. Based on the data of the functional activities of each manufacturing greenfield investment project in China from 2003 to 2018, this paper constructs specialization index of the upstream and downstream functional division of labor of value chains, and theoretically explains and empirically tests the impact and mechanism of the functional upgrading of the value chain driven by the improvement of foreign investment quality on the embodied emissions in China’s export trade. The results show that the functional upgrading of the value chain can significantly reduce the embodied emissions in China’s export trade. The mechanism analysis shows that the functional upgrading of the value chain driven by the improvement of the quality of foreign investment mainly plays a role in reducing the embodied emissions in China’s export trade through the optimization effect of factor structure, the effect of human capital accumulation and the effect of service demand creation. Extended analysis finds that high-quality foreign investment engaged in upstream functional activities and inflows into eastern China have more obvious inhibitory effects on the embodied emissions in export trade. At the same time, the functional upgrading of the value chain is more conducive to reducing the embodied emissions in export trade in pollution-intensive manufacturing industries. This paper verifies the “pollution halo” effect of high-quality foreign investment, and provides strong support for China to attract and utilize foreign investment more vigorously and promote high-level opening up under the new situation.
Risk factor assessment for post-thrombolytic coronary angiogram normalcy in young myocardial infarction patients
Authors: Mahadevan Venkatramani , Karuppiah Abirami , Venkatraman Shravan 
Published: December 2024

Abstract

Objectives
Acute myocardial infarction is a critical medical condition that poses a significant risk to life. It is distinguished by the abrupt cessation of blood flow to a specific segment of the cardiac muscle. Acute myocardial infarction accounts for more than 15 % of global mortality annually.

Methods and Results
A total of 433 young patients admitted with acute coronary syndrome – myocardial infarction underwent thrombolysis with fibrin specific agents followed by underwent diagnostic coronary angiogram between 01.09.2021 and 31.10.2022. The odds ratio showed a value of 1.973, which is much higher than the individuals with diabetes (0.306). Young individuals (25.9 %) with hypertension have a greater chance of recovery by thrombolysis.

Conclusions
The factors that contribute for the myocardial infarction should be recognized and addressed. Recognizing and addressing these risk factors through education, lifestyle modifications, and early intervention are crucial for preventing myocardial infarction and promoting good health.