bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGGUNAAN RANGKAIAN BOOSTER CONVERTER DAN IC-TP4056 UNTUK LAMPU JALAN MURAH
Authors: Ananda Ricki , Handoko Wiwin 
Published: February 2021

Abstract: PJU (Public Street Lighting), is regulated in the regulation of the Minister of Transportation of the Republic of Indonesia Number 27 of 2018, concerning street lighting. In line with the statement of the village minister, development of underdeveloped areas and transmigration (Mendes PDTT), eko putro Sandjojo, said that village funds could be used to make street lamps for villages that do not have street lights. The area of the northern ring road, sub-district of datuk bandar timur in the direction of the port of Teluk Nibung, part of the road has no street lighting at night, plus the road conditions are still classified as red soil. Based on the results of field observations, the team researched making cheap street lamps, by utilizing the basic work system of the joule tief circuit, where the input is 7.4 VDC (in 3.7VDC arranged in series-parallel) with a lamp load of 12 watts multiplied by 4 lamps, with a total load. 48 watts, get the frequency measurement results of 12.30 Khz and Iout 0.14A, and Vpk-pk 82 V. Charging input is 7.4VDC, the current 19800mAh in the battery is divided by the maximum current of the solar module 1 watt, which is 160mA, so the charging time the battery is in the range of 2.1 hours. For the design of the lampposts that were made, using a paralon pipe with a length of 5m, with a circle diameter of 9cm, and a second pole connecting 1.5 m long with a circle diameter of 5cm. Keywords: Cheap street lights; joule tief series; 1 watt solar panel Abstrak : PJU (Penerangan Jalan Umum), diatur dalam peraturan mentri perhubungan republik indonesia nomor 27 tahun 2018, tentang alat penerangan jalan. Sejalan dengan pernyataan mentri desa, pembangunan daerah tertinggal dan transmigrasi (Mendes PDTT) eko putro Sandjojo, mengatakan bahwa dana desa bisa digunakan untuk membuat lampu jalan bagi desa yang tidak memiliki lampu jalan. Wilayah jalan lingkar utara, kecamatan datuk bandar timur searah menuju pelabuhan teluk nibung, sebahagian dari jalan tersebut tidak memiliki penerangan jalan dimalam hari, ditambah dengan kondisi jalan yang masih tergolong tanah merah. Berdasarkan hasil pengamatan dilapangan maka tim meneliti membuat lampu jalan murah, dengan memanfaatkan dasar sistem kerja rangkaian joule tief, dimana untuk input 7,4 VDC (in 3,7VDC disusun seri-paralel) dengan beban lampu 12 watt dikalikan 4 lampu, dengan total beban 48 watt, mendapati hasil pengukuran frequensi 12,30 Khz dan Iout 0,14A, dan Vpk-pk 82 V. Pengisian input 7,4VDC didapati, arus 19800mAh pada baterai dibagi dengan arus maksimum modul surya 1 watt, yaitu 160mA, sehingga lama pengisian baterai berada pada rentang waktu 2,1 jam. Untuk rancangan tiang lampu yang dibuat, menggunakan pipa paralon dengan panjang 5m, dengan diameter lingkaran 9cm, dan penyambung tiang kedua sepanjang 1,5 m dengan diameter lingkaran 5cm. Kata Kunci : Lampu jalan murah; rangkaian joule tief; panel surya 1 watt
Urgensi Nilai-Nilai Pendidikan Islam dalam Kegiatan Pencak Silat Gasmi di Pondok Pesantren Al-Mahrusiyah Lirboyo Kediri
Authors: Faza Shohibul , Ubaidilah Syafik 
Published: February 2021

This research is motivated by the large number of people who assume that in the activities of pencak silat there are many negative things especially to their members. This research is a descriptive qualitative research. The results of this study found interesting facts that in this martial arts activities there are Islamic educational values, namely the value of faith (I'tiqodiyyah), moral values ​​(khuluqiyyah), and amaliyah values. The form of internalization of Islamic education values ​​towards pencak silat activities is to teach the values ​​of faith by inviting prayer together before holding exercises and also sparring, inviting that to always trust Allah SWT. Always respect people who are older both in terms of age and knowledge. Always maintain brotherhood and create benefit for the people of the nation's progress. After the researcher gets the data, the writer gives a few suggestions: 1) a trainer or chairman should discipline the training time so that the results of the exercise can be as expected. 2) More emphasis on the values ​​of Islamic education so that its adherents can achieve the basic objectives of the GASMI martial arts.
[Penelitian ini dilatarbelakangi oleh banyaknya masyarakat yang beranggapan bahwasanya dalam kegiatan pencak silat itu banyak mengandung hal-hal negatif terlebih pada anggotanya. Penelitian ini adalah penelitian deskriptif kualitatif. Hasil penelitian ini ditemukan fakta menarik bahwasanya dalam kegiatan pencak silat ini terdapat nilai-nilai pendidikan Islam yaitu nilai keimanan (I’tiqodiyyah), nilai akhlak (khuluqiyyah), dan nilai amaliyah. Adapun bentuk internalisasi nilai-nilai pendidikan Islam terhadap kegiatan pencak silat ini adalah dengan mengajarkan nilai-nilai keimanan dengan cara mengajak do’a bersama sebelum diadakannya latihan danjuga latih tanding, mengajak agar supaya selalu tawakal kepada Allah SWT. Selalu menghormati orang yang lebuh tua baik baik dari segi umur maupun ilmunya.Selalu menjaga persaudaraan dan menciptakan kemaslahatan masyarakat kemajuan bangsa. Setelah peneliti mendapatkan data-data maka penulis memberikan sedikit saran: 1) hendaknya seorang pelatih maupun ketua lebih mendisiplinkan waktu latihan agar hasil dari latihan tersebut bisa seperti apa yang di harapkan. 2) Lebih menekankan lagi nilai-nilai pendidikan islam agar para penganutnya bisa mencapai tujuan dasar dari pencak silat GASMI tersebut]
Implementasi Model Pembelajaran Card Sort Pada Mata Pelajaran Akidah Akhlak Kelas IV MI Al-Islam Desa Pranggang Kecamatan Plosoklaten Kabupaten Kediri
Authors: Hasanah Uswatun , Wahyuni Siti 
Published: February 2021

Learning by using card sort can be through the principle of apperception, the principle of motivation, the principle of self-employment and the principle of regular repetition. With card sort students are more motivated in learning so they are able to understand lessons and improve learning outcomes in accordance with the expected completeness standards. This research method is qualitative. As with the direction of qualitative research, the collected data is analyzed with the provision of intellectual weapons in the form of theory as presented in chapter II to obtain various interpretative descriptions in accordance with the rules of scientific research that are logical and rational. The results of this study are: (1) The application of the Card Sort Method to grade IV students in akidah akhak subjects in MI Al-Islam Desa Pranggang Kecamatan Plosoklaten Kabupaten Kediri, the teacher gives an index card containing the material of moral study. The more students there are, the more card pairs there are. (2) Changes in student learning outcomes after being taught using class IV card sort method in akidah akhlak subjects in MI Al-Islam Desa Pranggang Kecamatan Plosoklaten Kabupaten Kediri, are the cognitive test results of students getting an average score of 84.14, on the affective aspects of students have a sense of faith and devotion to God in psychomotor students implementing Islamic religious teachings in daily life so as to shape the knowledge, attitudes and skills of all students here according to the target, which is to integrate the cognitive, affective and psychomotor domains in all learning activities. And the students' response to this learning method is very good because of students like the method of learning card sort
Exploring the Influences of Temperature on “H-Shaped” Glycerol Dialkyl Glycerol Tetraethers in a Stratigraphic Context: Evidence From Two Peat Cores Across the Late Quaternary
Authors: Tang Xiaotong , Naafs B. David A. , Pancost Richard D. , Liu Zhao , Fan Tongyu , Zheng Yanhong 
Published: February 2021

Unusual “H-Shaped” branched and isoprenoidal glycerol monoalkyl glycerol tetraethers (GMGTs, or H-GDGTs) have been found in peat, lake, and ocean sediments. A survey of recent samples from a modern global peat database suggested that there is a relationship between the abundance of H-GDGTs relative to regular GDGTs and temperature. However, this relationship has not been widely explored, including in a historical, stratigraphic or geological context. Here, we report the abundance and distribution of H-iso- and H-brGDGTs in two (Hani and Gushantun) peat cores from northeastern China through the late Quaternary (last 15 kyr) to examine whether the relationship between temperature and the relative abundance of H-GDGTs is preserved downcore. The results indicate that high relative abundances of H-brGDGTs are associated with high (or increasing) reconstructed mean annual air temperature (MAATpeat), albeit with considerable divergence in some intervals. On the other hand, high relative abundances of H-isoGDGTs are generally associated with low (or decreasing) MAATpeat. These findings are partly inconsistent with the observations from the modern database of globally distributed peats, which showed that the abundance of both (br- and iso-) H-GDGTs is positively correlated with temperature. The deviation in the relationship between H-isoGDGTs and temperature suggests that additional factors, for example pH and shifts in archaeal community related to hydrology, exert an influence on the abundance of H-isoGDGTs on the long-term.
Relevance of QuantiFERON-TB Gold Plus and Heparin-Binding Hemagglutinin Interferon-γ Release Assays for Monitoring of Pulmonary Tuberculosis Clearance: A Multicentered Study
Authors: Chedid Carole , Kokhreidze Eka , Tukvadze Nestani , Banu Sayera , Uddin Mohammad Khaja Mafij , Biswas Samanta , Russomando Graciela , Acosta Chyntia Carolina Díaz , Arenas Rossana , Ranaivomanana Paulo PR. , Razafimahatratra Crisca , Herindrainy Perlinot , Rakotonirina Julio , Raherinandrasana Antso Hasina , Rakotosamimanana Niaina , Hamze Monzer , Ismail Mohamad Bachar , Bayaa Rim , Berland Jean-Luc , De Maio Flavio , Delogu Giovanni , Endtz Hubert , Ader Florence , Goletti Delia , Hoffmann Jonathan 
Published: February 2021

BackgroundTuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The objective of this study was to monitor the response to a heparin-binding hemagglutinin (HBHA) interferon-γ (IFN-γ) release assay (IGRA) and QuantiFERON-TB Gold Plus (QFT-P) and to analyze plasma IFN-γ levels according to sputum culture conversion and immune cell counts during treatment.MethodsThis multicentered cohort study was based in Bangladesh, Georgia, Lebanon, Madagascar, and Paraguay. Adult, non-immunocompromised patients with culture-confirmed pulmonary TB were included. Patients were followed up at baseline (T0), after two months of treatment (T1), and at the end of therapy (T2). Clinical data and blood samples were collected at each timepoint. Whole blood samples were stimulated with QFT-P antigens or recombinant methylated Mycobacterium tuberculosis HBHA (produced in Mycobacterium smegmatis; rmsHBHA). Plasma IFN-γ levels were then assessed by ELISA.FindingsBetween December 2017 and September 2020, 132 participants completed treatment, including 28 (21.2%) drug-resistant patients. rmsHBHA IFN-γ increased significantly throughout treatment (0.086 IU/ml at T0 vs. 1.03 IU/ml at T2, p &lt; 0.001) while QFT-P IFN-γ remained constant (TB1: 0.53 IU/ml at T0 vs. 0.63 IU/ml at T2, p = 0.13). Patients with low lymphocyte percentages (&lt;14%) or high neutrophil percentages (&gt;79%) at baseline had significantly lower IFN-γ responses to QFT-P and rmsHBHA at T0 and T1. In a small group of slow converters (patients with positive cultures at T1; n = 16), we observed a consistent clinical pattern at baseline (high neutrophil percentages, low lymphocyte percentages and BMI, low TB1, TB2, and MIT IFN-γ responses) and low rmsHBHA IFN-γ at T1 and T2. However, the accuracy of the QFT-P and rmsHBHA IGRAs compared to culture throughout treatment was low (40 and 65% respectively). Combining both tests improved their sensitivity and accuracy (70–80%) but not their specificity (&lt;30%).ConclusionWe showed that QFT-P and rmsHBHA IFN-γ responses were associated with rates of sputum culture conversion. Our results support a growing body of evidence suggesting that rmsHBHA IFN-γ discriminates between the different stages of TB, from active disease to controlled infection. However, further work is needed to confirm the specificity of QFT-P and rmsHBHA IGRAs for treatment monitoring.
YF-H-2015005, a CXCR4 Antagonist, for the Mobilization of Hematopoietic Stem Cells in Non-Hodgkin Lymphoma Patients: A Randomized, Controlled, Phase 3 Clinical Trial
Authors: Liu Weiping , Li Yufu , Wang Quanshun , Su Hang , Ding Kaiyang , Shuang Yuerong , Gao Sujun , Zou Dehui , Jing Hongmei , Chai Ye , Zhang Yicheng , Liu Lihong , Wang Chunling , Liu Hui , Lin Jinying , Zhu Haiyan , Yao Chen , Yan Xiaoyan , Shang Meixia , Wang Shufang , Chang Fengyuan , Wang Xiaopei , Zhu Jun , Song Yuqin 
Published: February 2021

Background: YF-H-2015005, a novel CXCR4 antagonist, has been proven to increase the quantities of circulating hematopoietic stem cells (HSCs), which results in an adequate collection of HSCs in non-Hodgkin lymphoma (NHL) patients.Methods: This was a multicenter, double-blind, randomized (1:1), placebo-controlled phase III clinical trial. All patients received granulocyte colony-stimulating factor (G-CSF) for up to 8 consecutive days. YF-H-2015005 or placebo was administrated on the evening of day 4 and continued daily for up to 4 days. Apheresis was conducted 9–10 h after each dose of YF-H-2015005 or placebo. The primary endpoint was the proportion of NHL patients procuring ≥5 × 106/kg CD34+ HSCs within ≤4 apheresis sessions.Results: In total, 101 patients with NHL were enrolled. The proportions of patients achieving primary endpoint were 57 and 12% in YF-H-2015005 and placebo groups, respectively (P &lt; 0.001). Moreover, a higher proportion of YF-H-2015005-treated patients reached a minimum target collection of ≥2 × 106/kg CD34+ HSCs in ≤4 apheresis days compared to placebo-treated patients (86 vs. 38%, P &lt; 0.001). Furthermore, the median time to collect ≥2 or 5 × 106/kg CD34+ HSCs were 1 and 3 days in YF-H-2015005-treated patients, but 4 days and not reached in placebo-treated patients, respectively. No severe treatment emergent adverse events were observed in both YF-H-2015005 treatment and placebo groups.Conclusions: YF-H-2015005 plus G-CSF regimen was a tolerable combination with high efficacy, which might be used to rapidly mobilize and collect HSCs in NHL patients.
The Effect of Perturbation-Based Balance Training and Conventional Intensive Balance Training on Reactive Stepping Ability in Individuals With Incomplete Spinal Cord Injury or Disease: A Randomized Clinical Trial
Authors: Unger Janelle , Chan Katherine , Lee Jae W. , Craven B. Catharine , Mansfield Avril , Alavinia Mohammad , Masani Kei , Musselman Kristin E. 
Published: February 2021

Introduction: Impaired balance leads to falls in individuals with motor incomplete spinal cord injury or disease (iSCI/D). Reactive stepping is a strategy used to prevent falls and Perturbation-based Balance Training (PBT) can improve this ability.Objective: The objective of this study was to determine if PBT results in greater improvements in reactive stepping ability than frequency-matched Conventional Intensive Balance Training (CIBT) in adults with iSCI/D.Design: Randomized clinical trial.Setting: Tertiary SCI/D rehabilitation center.Participants: Twenty-one adults with chronic (&gt;1 year) iSCI/D were randomized. Due to one drop out 20 participants completed the study.Methods: Participants were randomly allocated to complete either PBT or CIBT three times per week for 8 weeks. Both programs included challenging static and dynamic balance tasks, but the PBT group also experienced manual external balance perturbations.Main Outcome Measures: Assessments of reactive stepping ability using the Lean-and-Release test were completed at baseline, and after 4 and 8 weeks of training, and 3 and 6 months after training completion. A blinded assessor evaluated secondary outcomes.Results: Twenty-five participants were screened and 21 consented; one withdrew. Ten PBT and 10 CIBT participants were included in analyses. Across all participants there were improvements in reactive stepping ability (p = 0.049), with retention of improvements at follow up assessments. There were no differences in reactive stepping ability between groups [median (interquartile range): PBT 0.08 (0.68); CIBT 0.00 (0.22)]. One participant in the PBT group experienced a non-injurious fall during training.Conclusions: Balance training is beneficial for individuals with iSCI/D, but the addition of manual perturbations (i.e., PBT) did not prove advantageous for performance on a measure of reactive stepping ability.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT02960178.
A Study Protocol for a Parallel-Designed Trial Evaluating the Impact of Plant-Based Diets in Comparison to Animal-Based Diets on Health Status and Prevention of Non-communicable Diseases—The Nutritional Evaluation (NuEva) Study
Authors: Dawczynski Christine 
Published: February 2021

Background and Aims: Currently, there is a continuing upward trend for plant-based lifestyles in Germany and Europe. The implementation of vegetarian and vegan lifestyles is characterized by omitting defined food groups such as fish, meat, sausage (vegetarians), or dairy products and honey (vegans). This carries the risk of an undersupply of valuable nutrients. The NuEva study is designed to examine this hypothesis and to evaluate the impact of plant-based diets on health status and disease risk.Methods: The NuEva study is a parallel-designed trial with at least 55 participants for each diet (vegetarian, vegan, flexitarian [rare meat/sausage consumption, once or twice per week]), and participants who consume a traditional Western diet as the control group. In the screening period critical nutrients are identified for the studied diets by analysis of a broad spectrum of nutrients in the human samples (fatty acids, vitamins, minerals, trace elements, nutrient metabolites).Results: Based on the data from the screening period, defined menu plans, ensuring an adequate nutrient intake in accordance with the nutritional guidelines are prepared for each group. The plans are adapted and personalized to individual energy requirements based on the basal metabolic rate and physical activity level. The compliance with the NuEva concept and their impact on nutrient status and cardiovascular risk factors are validated during the intervention period of the NuEva study over 1 year. To investigate the impact of the studied diets on the microbiome, feces samples are collected at the beginning and after the 12 months intervention period (follow up: 12 months).Conclusion: The NuEva study is designed to investigate the impact of common diets on health and disease status, with focus on prevention of cardiovascular diseases. In addition, the effectiveness of the prepared nutritional coaching strategy, ensuring optimal nutrient intake in accordance with the guidelines, is validated during the intervention period of the NuEva study.Clinical Trial Registration: Registered under ClinicalTrials.gov Identifier no. NCT03582020.
CD19 and CD30 CAR T-Cell Immunotherapy for High-Risk Classical Hodgkin’s Lymphoma
Authors: Xue YuanBo , Lai Xun , Li RuiLei , Ge ChunLei , Zeng BaoZhen , Li Zhen , Fu QiaoFen , Zhao LiuFang , Dong SuWei , Yang JinYan , Guo JiYin , Meng QingYin , Tan QingHua , Li ZhenHui , Ding HaiYan , Zhang YanLei , Liu ShaoHui , Chang Alex H. , Yao Hong , Luo RongCheng 
Published: February 2021

BackgroundIn clinical applications of CAR T-cell therapy, life-threatening adverse events including cytokine release syndrome and neurotoxicity can lead to treatment failure. Outcomes of patients treated with anti-CD30 CAR T- cell have been disappointing in relapsing/refractory (r/r) classical Hodgkin’s Lymphoma (cHL).MethodsIn order to understand the applicable population of multiple CAR T-cell therapy, we examined the expression of CD19, CD20, and CD30 by immunohistochemistry (IHC) in 38 paraffin-embedded specimens of cHL. In the past two years, we found only one patient with cHL who is eligible for combined anti-CD19 and CD30 CAR T-cell treatment. This patient’s baseline characteristics were prone to severe adverse events. We treated this patient with low doses and multiple infusions of anti-CD19 and CD30 CAR T-cell.ResultsThe positive expression of CD19+ + CD30+ in Reed-Sternberg (RS) cells is approximately 5.2% (2/38). The patient we treated with combined anti-CD19 and CD30 CAR T-cell did not experience severe adverse events related to CAR T-cell therapy and received long term progression-free survival (PFS).ConclusionFor high risk r/r cHL patients, low doses of CAR T-cell used over different days at different times might be safe and effective. More clinical trials are warranted for CD19 and CD30 CAR T-cell combination therapy.
Pulmonary Involvement in Children With Systemic Lupus Erythematosus
Authors: Dai Ge , Li Linlin , Wang Ting , Jiang Wujun , Ma Jie , Yan Yongdong , Chen Zhengrong 
Published: February 2021

Background: Symptomatic pulmonary involvement in systemic lupus erythematosus (SLE) seems not uncommon in children. However, there are few data on the characteristics and laboratory parameters of SLE patients with pulmonary involvement.Methods: This was a hospital-based study involving 111 SLE patients from 1 January 2012 to 31 December 2016. The demographic, clinical, and laboratory data of the patients were prospectively collected. They were followed as outpatients until December 2019. Clinical characteristics and laboratory parameters of patients with and without pulmonary involvement were compared.Results: Of the 111 patients with SLE, we identified 18 patients (16.2%) with pulmonary involvement. The most common HRCT findings were ground glass opacity, interlobular septal thickening, bilateral diffuse infiltrates, and pleurisy/pleural effusion (55.6, 50, 50, and 44.4%, respectively). SLE patients with pulmonary involvement tended to have a longer disease duration (14 [12–24.5] vs. 5 [2–9] months, P &lt; 0.01). We also observed a significant association between the presence of anti-Sm antibody, ANCA, Anti-RNP and the presence of pulmonary involvement of SLE (all P &lt; 0.001).Conclusions: Lung involvement was frequent in SLE patients from Southeast China. Patients with a longer duration of symptoms before SLE diagnosis tended to have pulmonary involvement. When children with SLE are found to have anti-RNP antibody and positive ANCA, it should be alert to the occurrence of pulmonary involvement.