bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of Nociceptive Processing: Effect of Intra-Epidermal Electric Stimulus Properties on Detection Probability and Evoked Potentials
Authors: van den Berg Boudewijn , Buitenweg Jan R. 
Published: January 2021

AbstractMonitoring nociceptive processing is a current challenge due to a lack of objective measures. Recently, we developed a method for simultaneous tracking of psychophysical detection probability and brain evoked potentials in response to intra-epidermal stimulation. An exploratory investigation showed that we could quantify nociceptive system behavior by estimating the effect of stimulus properties on the evoked potential (EP). The goal in this work was to accurately measure nociceptive system behavior using this method in a large group of healthy subjects to identify the locations and latencies of EP components and the effect of single- and double-pulse stimuli with an inter-pulse interval of 10 or 40 ms on these EP components and detection probability. First, we observed the effect of filter settings and channel selection on the EP. Subsequently, we compared statistical models to assess correlation of EP and detection probability with stimulus properties, and quantified the effect of stimulus properties on both outcome measures through linear mixed regression. We observed lateral and central EP components in response to intra-epidermal stimulation. Detection probability and central EP components were positively correlated to the amplitude of each pulse, regardless of the inter-pulse interval, and negatively correlated to the trial number. Both central and lateral EP components also showed strong correlation with detection. These results show that both the observed EP and the detection probability reflect the various steps of processing of a nociceptive stimulus, including peripheral nerve fiber recruitment, central synaptic summation, and habituation to a repeated stimulus.
Effects of nuisance submerged vegetation on the fauna in Norwegian rivers
Authors: Velle Gaute , Skoglund Helge , Barlaup Bjørn T. 
Published: January 2021

AbstractThe abundance of aquatic vegetation is increasing in rivers and lakes worldwide. The aim of this study was to find how the macrophyte Juncus bulbosus Linnaeus affects salmonids and benthic macroinvertebrates in Norwegian rivers. The proliferation of J. bulbosus in the study rivers commenced after the development of hydropower in the 1960s and 1970s. J. bulbosus is now considered a nuisance for humans in many areas of the rivers. We found a higher density of juvenile fish and higher density, weight and species richness of invertebrates in areas with J. bulbosus than in areas with gravel, suggesting that the vegetation is not limiting fish and invertebrates. This may be because macrophytes increase the surface area and provide shelter, food and a variety of ecological niches. Adult salmonid fish can be negatively affected when their spawning grounds are covered by vegetation. However, overgrowth is not common and may take years since fish clear the river bed of macrophytes during redd digging, indicating competition between macrophytes and fish for riverbed habitat. Our results suggest that one should not assume that outgrowths of macrophytes have negative impacts on the ecosystem. It is important to map all impacts and distinguish nuisance to humans from effects on the ecosystem.
Synthetic tethered silver nanoparticles on reduced graphene oxide for alkaline oxygen reduction catalysis
Authors: Tinker Henry R. , Bhide Malavika A. , Magliocca Emanuele , Miller Thomas S. , Knapp Caroline E. 
Published: January 2021

AbstractThere is currently an enormous drive to move away from the use of Pt group metals in catalysis, particularly for fuel cells, because of their increasing rarity and cost. Simultaneously, there have been advances in the application of graphene supported nanoparticular catalysts. However, these Pt-free, graphene supported catalysts can be complex to produce, show poor catalytic activity and degrade quickly due to particle agglomeration or isolation. Herein, we report a one-pot synthesis of silver nanoparticles (NPs) tethered to a reduced graphene oxide (rGO) template via organic linkages. This is one of the few silver precursor formations that have been combined with graphene oxide (GO) to simultaneously establish linkage binding sites, reduce GO and yield tethered nanoparticles. These materials are shown to efficiently catalyze the oxygen reduction reaction in alkaline environments, with aminoethanol linkages to 21.55 ± 2.88 nm Ag particles exhibiting the highest catalytic activity via the four-electron pathway. This method, therefore, offers a straightforward route to produce effective catalysts from inexpensive precursors, which could be developed further for significant industrial application.
Graphical abstract
In situ observation of the impact of hydrogen bubbles in Al–Cu melt on directional dendritic solidification
Authors: Werner T. , Becker M. , Baumann J. , Pickmann C. , Sturz L. , Kargl F. 
Published: January 2021

AbstractMuch research has already been focused on the solid-bubble interaction in the interdendritic space for solidifying materials. However, commonly, bubble nucleation is not limited to the mushy zone but also occurs in the liquid melt. In the present research on an Al-$$10 \, \%\mathrm {wt. \,}$$

10

%

wt
.

Cu alloy, the interaction between these bubbles and the approaching solidification front becomes apparent under in situ X-radiography and allows for new insights into the influence of bubbles on the solidifying microstructure. The observed effects comprise bulging of the solidification front toward the bubble, bending of dendrites in front of the bubble, coronal outgrowths surrounding the bubbles, as well as bubble growth, bubble pushing, and bubble eruption. It is found that for the present Al–Cu alloy, the local variation in the solidification speed can be attributed to the bubbles’ insulating properties. The range of this effect was observed to be up to $$900 \,\upmu \text {m}$$

900

μ
m

, depending on the bubble diameter, locally increasing solidification speed by up to $$350 \, \%$$

350

%

. The influences of Marangoni vortices and coronal nucleation of misoriented dendrites around bubbles on the homogeneity of the microstructure are discussed. A comparison with experiments on model alloys and simulations from various other studies highlights the similarities and differences to this metallic alloy system.
Selective oxidation of aromatic alcohols in the presence of C3N4 photocatalysts derived from the polycondensation of melamine, cyanuric and barbituric acids
Authors: García-López Elisa I. , Abbasi Zahra , Di Franco Francesco , Santamaria Monica , Marcì Giuseppe , Palmisano Leonardo 
Published: January 2021

AbstractA set of C3N4 samples has been prepared by using melamine, cyanuric acid and barbituric acid as the precursors. The materials were subjected both to physical and chemical characterization and were used as photocatalysts for the selective oxidation of aromatic alcohols in water suspension under UV and visible irradiation. The photoactivity of the materials versus the partial oxidation of four substituted benzyl alcohols was investigated. The type and position of the substituents in the aromatic molecule influenced conversion and selectivity to the corresponding aldehyde. The presence of barbituric and cyanuric acids in the preparation method has changed the graphitic-C3N4 structure, and therefore both the characteristics of the material and the ability of light to activate the surface of the photocatalyst. The most active material prepared in the presence of melamine and cyanuric acid showed a remarkable selectivity towards the aldehyde even under visible irradiation.
Resolutions provide reasons or: “how the Cookie Monster quit cookies”
Authors: Bales Adam , Handfield Toby 
Published: January 2021

AbstractWhy should we typically act in accordance with our resolutions when faced with the temptation to do otherwise? A much-maligned view suggests that we should do so because resolutions themselves provide us with reasons for action. We defend a version of this view, on which resolutions providesecond-orderreasons. This account avoids the objections typically taken to be fatal for the view that resolutions are reasons, including the prominent bootstrapping objections.
Does general relativity highlight necessary connections in nature?
Authors: Vassallo Antonio 
Published: January 2021

AbstractThe dynamics of general relativity is encoded in a set of ten differential equations, the so-calledEinstein field equations. It is usually believed that Einstein’s equations represent a physical law describing the coupling of spacetime with material fields. However, just six of these equations actually describe the coupling mechanism: the remaining four represent a set of differential relations known asBianchi identities. The paper discusses the physical role that the Bianchi identities play in general relativity, and investigates whether these identities—quapart of a physical law—highlight some kind ofa posteriorinecessity in a Kripkean sense. The inquiry shows that general relativistic physics has an interesting bearing on the debate about the metaphysics of the laws of nature.
Development of a loop-mediated isothermal amplification (LAMP) assay for the identification of the invasive wood borer Aromia bungii (Coleoptera: Cerambycidae) from frass
Authors: Rizzo Domenico , Luchi Nicola , Da Lio Daniele , Bartolini Linda , Nugnes Francesco , Cappellini Giovanni , Bruscoli Tommaso , Salemi Chiara , Griffo Raffaele V. , Garonna Antonio P. , Rossi Elisabetta 
Published: January 2021

AbstractThe red-necked longhorn beetle Aromia bungii (Faldermann, 1835) (Coleoptera: Cerambycidae) is native to east Asia, where it is a major pest of cultivated and ornamental species of the genus Prunus. Morphological or molecular discrimination of adults or larval specimens is required to identify this invasive wood borer. However, recovering larval stages of the pest from trunks and branches causes extensive damage to plants and is timewasting. An alternative approach consists in applying non-invasive molecular diagnostic tools to biological traces (i.e., fecal pellets, frass). In this way, infestations in host plants can be detected without destructive methods. This paper presents a protocol based on both real-time and visual loop-mediated isothermal amplification (LAMP), using DNA of A. bungii extracted from fecal particles in larval frass. Laboratory validations demonstrated the robustness of the protocols adopted and their reliability was confirmed performing an inter-lab blind panel. The LAMP assay and the qPCR SYBR Green method using the F3/B3 LAMP external primers were equally sensitive, and both were more sensitive than the conventional PCR (sensitivity > 103 to the same starting matrix). The visual LAMP protocol, due to the relatively easy performance of the method, could be a useful tool to apply in rapid monitoring of A. bungii and in the management of its outbreaks.
High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing
Authors: Yao Yongxia , Qin Wei , Xing Bohang , Sha Na , Jiao Ting , Zhao Zhe 
Published: January 2021

AbstractHigh performance hydroxyapatite (HA) ceramics with excellent densification and mechanical properties were successfully fabricated by digital light processing (DLP) three-dimensional (3D) printing technology. It was found that the sintering atmosphere of wet CO2 can dramatically improve the densification process and thus lead to better mechanical properties. HA ceramics with a relative density of 97.12% and a three-point bending strength of 92.4 MPa can be achieved at a sintering temperature of 1300 , which makes a solid foundation for application ℃ in bone engineering. Furthermore, a relatively high compressive strength of 4.09 MPa can be also achieved for a DLP-printed p-cell triply periodic minimum surface (TPMS) structure with a porosity of 74%, which meets the requirement of cancellous bone substitutes. A further cell proliferation test demonstrated that the sintering atmosphere of wet CO2 led to improve cell vitality after 7 days of cell culture Moreover, with the possible benefit from the bio-inspired structure, the 3D-printed TPMS structure significantly improved the cell vitality, which is crucial for early osteogenesis and osteointegration.
Effect of processing parameters on in situ screen printing-assisted synthesis and electrical properties of Ti3SiC2-based structures
Authors: Lorenz Mylena , Travitzky Nahum , Rambo Carlos R. 
Published: January 2021

AbstractThis work reports on the development of pastes containing Ti, TiC, Si, and C elementary powders for in situ synthesis of Ti3SiC2 via screen printing. Four paste compositions were manufactured using two powder mixtures (Ti/Si/C and Ti/TiC/Si/C) with different stoichiometry. The pastes were screen printed onto Al2O3 substrates and sintered at 1400 ℃ in argon varying the dwell time from 1 to 5 h. The printed pastes containing TiC and excess of Si exhibited the lowest surface roughness and after 5 h sintering comprised of Ti3SiC2 as the majority phase. The electrical conductivity of this sample was found to range from 4.63×104 to 2.57×105 S·m–1 in a temperature range of 25–400 ℃.
Cross-border copyright, complexity and collaboration: Approaching intellectual property across an international consortium of photo archives
Authors: Fournier Melissa Gold 
Published: January 2021

AbstractWhat are the cross-border intellectual property and copyright issues faced by PHAROS, an international consortium of photo archives, in the creation of an open access research platform? How does the consortium define open access? Are approaches to copyright in reproductive media across the US, UK and EU compatible, and can 14 partners from six countries agree to assess and express rights in the same way? Developments in the field and the consortium's 2020 International Copyright Workshop project have helped PHAROS define and address these issues.
Realization of analytic moduli for parabolic Dulac germs
Authors: MARDEŠIĆ PAVAO , RESMAN MAJA 
Published: January 2021

AbstractIn a previous paper [P. Mardešić and M. Resman. Analytic moduli for parabolic Dulac germs. Russian Math. Surveys, to appear, 2021, arXiv:1910.06129v2.] we determined analytic invariants, that is, moduli of analytic classification, for parabolic generalized Dulac germs. This class contains parabolic Dulac (almost regular) germs, which appear as first-return maps of hyperbolic polycycles. Here we solve the problem of realization of these moduli.
Are prescription misuse and illicit drug use etiologically distinct? A genetically-informed analysis of opioids and stimulants
Authors: Dash Genevieve F. , Martin Nicholas G. , Agrawal Arpana , Lynskey Michael T. , Slutske Wendy S. 
Published: January 2021

AbstractBackgroundDrug classes are grouped based on their chemical and pharmacological properties, but prescription and illicit drugs differ in other important ways. Potential differences in genetic and environmental influences on the (mis)use of prescription and illicit drugs that are subsumed under the same class should be examined. Opioid and stimulant classes contain prescription and illicit forms differentially associated with salient risk factors (common route of administration, legality), making them useful comparators for addressing this etiological issue.MethodsA total of 2410 individual Australian twins [Mage = 31.77 (s.d. = 2.48); 67% women] were interviewed about prescription misuse and illicit use of opioids and stimulants. Univariate and bivariate biometric models partitioned variances and covariances into additive genetic, shared environmental, and unique environmental influences across drug types.ResultsVariation in the propensity to misuse prescription opioids was attributable to genes (41%) and unique environment (59%). Illicit opioid use was attributable to shared (71%) and unique (29%) environment. Prescription stimulant misuse was attributable to genes (79%) and unique environment (21%). Illicit stimulant use was attributable to genes (48%), shared environment (29%), and unique environment (23%). There was evidence for genetic influence common to both stimulant types, but limited evidence for genetic influence common to both opioid types. Bivariate correlations suggested that prescription opioid use may be more genetically similar to prescription stimulant use than to illicit opioid use.ConclusionsPrescription opioid misuse may share little genetic influence with illicit opioid use. Future research may consider avoiding unitary drug classifications, particularly when examining genetic influences.
Narrative heroes and civic builders in Newcastle city region during the nineteenth century
Authors: Barke Michael , Taylor Peter J. 
Published: January 2021

AbstractThe literature on nineteenth-century Newcastle city region is a narrative of industrial progress premised upon technological prowess. But there is another story to be told about the transformation of a relatively small northern town into a conurbation with the attributes of a modern city. This second process of ‘rounding out’ the city with social, cultural and political institutions to accompany the economic prowess is relatively under-reported. In this study, we follow 1,621 individuals and compare their record of being mentioned in the literature to their participation in 343 local institutions. The focus is directed towards those who are much more visible in the literature compared to institutional membership – ‘narrative heroes’ – and those with the reverse pattern, much more to be found in institutions than in the literature – civic builders. The two sets of individuals are discussed and reasons for their contrasting positions are suggested.
Brachytherapy for Oesophageal Carcinoma: A Comprehensive Review of Literature and Techniques
Authors: Kulshrestha Rashi , Gupta Anil , Sharma Daya Nand , Singh Kishore 
Published: January 2021

AbstractIntroduction:Oesophageal carcinoma is one of the fatal cancers mainly because of its rapid spread and poor prognosis. Treatment modalities involves a multimodality approach, including surgery, radiation therapy and chemotherapy. Radiation therapy includes brachytherapy in the form of intraluminal radiation therapy. Brachytherapy permits delivery of high tumouricidal doses to superficial cancerous growth of the oesophagus while delivering much lower doses to the surrounding tissue. It is mostly given in combination with external beam radiation in patients with poor performance scores not likely to tolerate an aggressive chemoradiation regimen or as a boost to concurrent chemoradiotherapy. It is very effective in terms of local tumour control as well as in relieving symptoms in advanced/recurrent disease. Intraoperative brachytherapy and seed brachytherapy have also been tried to address the nodal disease.Methods:We undertook a review of the available literature and techniques developed in the past three decades to emphasise the role of brachytherapy in curative or palliative settings in the treatment of oesophageal carcinoma.Conclusion:Oesophageal brachytherapy will remain a tangible treatment of oesophageal cancer, although it is less commonly used due to high expertise requirement, lack of established evidence, risk of life-threatening complications and lack of interest in brachytherapy. It offers quick and useful palliation for a prolonged period, along with good quality of life and superior dosimetry. Use of novel applicators may allow dose escalation and lower toxicity. Seed brachytherapy is also emerging as a promising option in nodal recurrences.
Concurrent high-dose intensity-modulated radiotherapy and chemotherapy for unresectable locally advanced and metastatic pancreatic cancer: a pilot study
Authors: Matsumoto Kenichi , Miyamoto Akihiko , Kawase Tomoya , Murai Taro , Shibamoto Yuta 
Published: January 2021

AbstractAim:To evaluate the efficacy of concurrent chemotherapy and high-dose (≥55 Gy) intensity-modulated radiotherapy (CCIMRT) in comparison with chemotherapy alone and intensity-modulated radiotherapy (IMRT) alone for unresectable locally advanced or metastatic pancreatic cancer.Methods:Forty-six patients with pancreatic cancer undergoing CCIMRT (n = 17), chemotherapy alone (n = 16) or IMRT alone (n = 13) were analysed. Overall survival (OS), locoregional progression-free survival (LRPFS) and gastrointestinal toxicities were evaluated. The median radiation dose was 60 Gy (range, 55–60) delivered in a median of 25 fractions (range, 24–30). Gemcitabine (GEM) alone, GEM + S-1, S-1 alone, FOLFIRINOX and GEM + nab-paclitaxel were used in CCIMRT and chemo-monotherapy.Results:The 1-year OS rate was 69% in the CCIMRT group, 27% in the chemotherapy group and 38% in the IMRT group (p = 0·12). The 1-year LRPFS rate was 73, 0 and 40% in the 3 groups, respectively (p = 0·012). Acute Grade ≥ 2 gastrointestinal toxicity (nausea, diarrhea) was observed in 12% (2/17) in the CCIMRT group, 25% (4/16) in the chemotherapy group and 7·7% (1/13) in the IMRT group (p = 0·38). Late Grade 3 gastrointestinal bleeding was observed in 6·3% (1/16) in the chemotherapy group.Conclusion:High-dose CCIMRT yielded acceptable toxicity and favorable OS and LRPFS.
Selecting life course frameworks to guide and communicate large new cohort studies: Generation Victoria (GenV) case study
Authors: Wang Jing , Hu Yanhong Jessika , Clifford Susan , Goldfeld Sharon , Wake Melissa 
Published: January 2021

AbstractWhile birth cohorts are shaped by underpinning life course frameworks, few if any report how they select them. This review aimed to (1) summarise publicly available frameworks relevant to planning and communicating large new early-life cohorts and (2) help select frameworks to guide and communicate Generation Victoria (GenV), a whole-of-state birth and parent cohort in planning in the state of Victoria, Australia. We identified potential frameworks from prior knowledge, networks and a pragmatic literature search in 2019. We considered for inclusion only frameworks with an existing visual graphic. We summarised each framework’s concept, then judged it on a seven-item matrix (Scope, Dimensions, Outcomes, Life course, Mechanisms, Multi-age, and Visual Clarity) to be of high, intermediate or low relevance to GenV. We presented and evaluated 14 life course frameworks across research and policy. Two, nine and three frameworks, respectively, were ranked as high, intermediate and low relevance to GenV, although none totally communicated its scope and intent. Shonkoff’s biodevelopmental framework was selected as GenV’s primary framework, adapted to include ongoing feedback loops through the life course and influence of an individual’s outcomes on the next generation. Because conceptual simplicity precluded the primary framework from capturing the wide range of relevant exposures, we selected the Australian Institute of Health and Welfare’s person-centred model as a secondary framework. This summary of existing life course frameworks may prove helpful to other cohorts in planning. Our transparent process and focus on visual communication are already assisting in explaining and selecting measures for GenV. The feasibility, comprehension and validity of these frameworks could be further tested at implementation.