bluuebunny/crossref_metadata_2025_split huggingface dataset:
A suitable time point for quantifying the radiochemical purity of 225Ac-labeled radiopharmaceuticals
Authors: Kelly James M. , Amor-Coarasa Alejandro , Sweeney Elizabeth , Wilson Justin J. , Causey Patrick W. , Babich John W. 
Published: December 2021

Abstract
Background
As 225Ac-labeled radiopharmaceuticals continue to show promise as targeted alpha therapeutics, there is a growing need to standardize quality control (QC) testing procedures. The determination of radiochemical purity (RCP) is an essential QC test. A significant obstacle to RCP testing is the disruption of the secular equilibrium between actinium-225 and its daughter radionuclides during labeling and QC testing. In order to accelerate translation of actinium-225 targeted alpha therapy, we aimed to determine the earliest time point at which the RCP of an 225Ac-labeled radiopharmaceutical can be accurately quantified.

Results
Six ligands were conjugated to macrocyclic metal chelators and labeled with actinium-225 under conditions designed to generate diverse incorporation yields. RCP was determined by radio thin layer chromatography (radioTLC) followed by exposure of the TLC plate on a phosphor screen either 0.5, 2, 3.5, 5, 6.5, or 26 h after the plate was developed. The dataset was used to create models for predicting the true RCP for any pre-equilibrium measurement taken at an early time point. The 585 TLC measurements span RCP values of 1.8–99.5%. The statistical model created from these data predicted an independent data set with high accuracy. Predictions made at 0.5 h are more uncertain than predictions made at later time points. This is primarily due to the decay of bismuth-213. A measurement of RCP > 90% at 2 h predicts a true RCP > 97% and guarantees that RCP will exceed 90% after secular equilibrium is reached. These findings were independently validated using NaI(Tl) scintillation counting and high resolution gamma spectroscopy on a smaller set of samples with 10% ≤ RCP ≤ 100%.

Conclusions
RCP of 225Ac-labeled radiopharmaceuticals can be quantified with acceptable accuracy at least 2 h after radioTLC using various methods of quantifying particle emissions. This time point best balances the need to accurately quantify RCP with the need to safely release the batch as quickly as possible.
White civilians’ implicit danger evaluation of police officers underlies explicit perception of police
Authors: Olivett Vincenzo J. , March David S. 
Published: December 2021

AbstractThe role of implicit processes during police-civilian encounters is well studied from the perspective of the police. Decades of research on the “shooter bias” suggests that implicit Black-danger associations potentiate the perception of threat of Black individuals, leading to a racial bias in the decision to use lethal force. Left understudied are civilians’ possible associations of police with danger and how such associations pervade behavior and explicit views of the police. The current work begins to address this gap. In two within-subjects studies, we separately assess police-threat (i.e., safety/danger) and police-valence (i.e., good/bad) associations as well as their relative influences on explicit perceptions of police. Study 1 revealed that implicit threat evaluations (police-danger associations) more strongly predicted negative explicit views of the police compared to implicit valence evaluations (police-negative associations). Study 2 replicated these findings and suggests that individuals evaluate the police as more dangerous versus negative when each response is pitted against each other within single misattribution procedure trials. The possible implications for explicit attitudes toward police reform and behavior during police-civilian encounters are discussed.
Effects of temporal and spatiotemporal cues on detection of dynamic road hazards
Authors: Wolfe Benjamin , Kosovicheva Anna , Stent Simon , Rosenholtz Ruth 
Published: December 2021

AbstractWhile driving, dangerous situations can occur quickly, and giving drivers extra time to respond may make the road safer for everyone. Extensive research on attentional cueing in cognitive psychology has shown that targets are detected faster when preceded by a spatially valid cue, and slower when preceded by an invalid cue. However, it is unknown how these standard laboratory-based cueing effects may translate to dynamic, real-world situations like driving, where potential targets (i.e., hazardous events) are inherently more complex and variable. Observers in our study were required to correctly localize hazards in dynamic road scenes across three cue conditions (temporal, spatiotemporal valid and spatiotemporal invalid), and a no-cue baseline. All cues were presented at the first moment the hazardous situation began. Both types of valid cues reduced reaction time (by 58 and 60 ms, respectively, with no significant difference between them, a larger effect than in many classic studies). In addition, observers’ ability to accurately localize hazards dropped 11% in the spatiotemporal invalid condition, a result with dangerous implications on the road. This work demonstrates that, in spite of this added complexity, classic cueing effects persist—and may even be enhanced—for the detection of real-world hazards, and that valid cues have the potential to benefit drivers on the road.
Systemic racism: individuals and interactions, institutions and society
Authors: Banaji Mahzarin R. , Fiske Susan T. , Massey Douglas S. 
Published: December 2021

AbstractSystemic racism is a scientifically tractable phenomenon, urgent for cognitive scientists to address. This tutorial reviews the built-in systems that undermine life opportunities and outcomes by racial category, with a focus on challenges to Black Americans. From American colonial history, explicit practices and policies reinforced disadvantage across all domains of life, beginning with slavery, and continuing with vastly subordinated status. Racially segregated housing creates racial isolation, with disproportionate costs to Black Americans’ opportunities, networks, education, wealth, health, and legal treatment. These institutional and societal systems build-in individual bias and racialized interactions, resulting in systemic racism. Unconscious inferences, empirically established from perceptions onward, demonstrate non-Black Americans’ inbuilt associations: pairing Black Americans with negative valences, criminal stereotypes, and low status, includinganimalrather thanhuman. Implicit racial biases (improving only slightly over time) imbed within non-Black individuals’ systems of racialized beliefs, judgments, and affect that predict racialized behavior. Interracial interactions likewise convey disrespect and distrust. These systematic individual and interpersonal patterns continue partly due to non-Black people’s inexperience with Black Americans and reliance on societal caricatures. Despite systemic challenges, Black Americans are more diverse now than ever, due to resilience (many succeeding against the odds), immigration (producing varied backgrounds), and intermarriage (increasing the multiracial proportion of the population). Intergroup contact can foreground Black diversity, resisting systemic racism, but White advantages persist in all economic, political, and social domains. Cognitive science has an opportunity: to include in its study of the mind the distortions of reality about individual humans and their social groups.
Assessing knowledge, attitude, and practices of veterinarians towards antimicrobial use and stewardship as drivers of inappropriate use in Abuja, Nigeria
Authors: Aworh Mabel Kamweli , Kwaga Jacob Kwada Paghi , Okolocha Emmanuel Chukwudi 
Published: December 2021

Abstract
Introduction
Antimicrobial resistance (AMR) has recently gained worldwide recognition, as the emergence of multi-drug resistant organisms has led to increased mortality and economic burden. This study aimed to assess knowledge, attitudes, and practices of veterinarians towards rational antimicrobial prescribing and identify factors influencing use.

Methods
We interviewed veterinary doctors in Abuja, Nigeria using a 50-point questionnaire distributed via WhatsApp mobile application. The questionnaire inquired about their experiences, knowledge, attitudes, and practices towards AMR and stewardship. We analyzed the data by calculating frequencies and proportions.

Results
Of 220 registered veterinarians, 144 (65.5%) participated in the survey. Most (52.8%) were within the age group 30 - 39 years; males (72.2%), with a Master’s degree (42.4%) and worked in public service (44.4%). Three-quarters (75.7%) had good knowledge of antimicrobials; 47.2% had received training on stewardship while 88.9% reported that they believed that overuse of antimicrobials was the major contributory factor towards AMR. Antimicrobial stewardship regulations are important in veterinary practice. Veterinarians were aware of the occurrence of resistant pathogens and agreed that restricting antimicrobial use in animal health care was necessary to reduce AMR.

Conclusion
Most respondents referred to the veterinary formulary (VF) when in doubt of the appropriate antimicrobial agent to administer. We recommend that the VF be updated following the WHO list of critically-important-antimicrobials (CIA) and veterinarians educated not to use these CIAs in the treatment of food animals.
Gut microbiome composition, not alpha diversity, is associated with survival in a natural vertebrate population
Authors: Worsley Sarah F. , Davies Charli S. , Mannarelli Maria-Elena , Hutchings Matthew I. , Komdeur Jan , Burke Terry , Dugdale Hannah L. , Richardson David S. 
Published: December 2021

AbstractBackgroundThe vertebrate gut microbiome (GM) can vary substantially across individuals within the same natural population. Although there is evidence linking the GM to health in captive animals, very little is known about the consequences of GM variation for host fitness in the wild. Here, we explore the relationship between faecal microbiome diversity, body condition, and survival using data from the long-term study of a discrete natural population of the Seychelles warbler (Acrocephalus sechellensis) on Cousin Island. To our knowledge, this is the first time that GM differences associated with survival have been fully characterised for a natural vertebrate species, across multiple age groups and breeding seasons.ResultsWe identified substantial variation in GM community structure among sampled individuals, which was partially explained by breeding season (5% of the variance), and host age class (up to 1% of the variance). We also identified significant differences in GM community membership between adult birds that survived, versus those that had died by the following breeding season. Individuals that died carried increased abundances of taxa that are known to be opportunistic pathogens, including several ASVs in the genusMycobacterium. However, there was no association between GM alpha diversity (the diversity of bacterial taxa within a sample) and survival to the next breeding season, or with individual body condition. Additionally, we found no association between GM community membership and individual body condition.ConclusionsThese results demonstrate that components of the vertebrate GM can be associated with host fitness in the wild. However, further research is needed to establish whether changes in bacterial abundance contribute to, or are only correlated with, differential survival; this will add to our understanding of the importance of the GM in the evolution of host species living in natural populations.
Platform economy: (dis-) embeddedness processes in urban spaces
Authors: Hardaker Sina 
Published: December 2021

AbstractDigital platforms, understood as multi-sided matchmakers, have amassed huge power, reimagining the role of consumers, producers, and even ownership. They increasingly dictate the way the economy and urban life is organized. Yet, despite their influential and far-reaching role in shaping our economic as well as sociocultural world, our understanding of their embeddedness, namely how their activities are embedded in systems of social and societal relationships and how they conceptualize their main functions and actions in relation to their wider setting, remains rudimentary. Consequently, the purpose of this frontier paper is threefold. Firstly, it reveals the need to discuss and evaluate (dis-)embedding processes in platform urbanism in order to understand the underlying dynamics of platform power and urban transformation. Secondly, it aims to reveal the main reasons in regard to the difficulties in pinpointing digital platforms embeddedness. Thirdly, it seeks to propose future research unravelling the (dis-)embeddedness of the platform economy.This paper argues for three main reasons namely unawareness, unaccountability and non-transparency of digital platforms that drive the lack of embeddedness and reaffirms platform power. This is mainly based on the configuration of new commodities, platforms’ strategic avoidance of labour protections and other regulatory frameworks as well as platforms’ secrecy in which they operate. This frontier paper argues that transferring the concept of embeddedness to the platform economy might serve as a valuable tool to understand and pinpoint essential dynamics and relationships at play, therefore proposing embeddedness as a basis for future research on the platform economy. It strongly argues that a more detailed understanding is urgently needed, in order to be able to understand, accompany and actively influence the development of the platform economy in regulatory terms.
A variant of raw observation approach for BDS/GNSS precise point positioning with fast integer ambiguity resolution
Authors: Zhao Qile , Guo Jing , Liu Sijing , Tao Jun , Hu Zhigang , Chen Gang 
Published: December 2021

AbstractThe Precise Point Positioning (PPP) technique uses a single Global Navigation Satellite System (GNSS) receiver to collect carrier-phase and code observations and perform centimeter-accuracy positioning together with the precise satellite orbit and clock corrections provided. According to the observations used, there are basically two approaches, namely, the ionosphere-free combination approach and the raw observation approach. The former eliminates the ionosphere effects in the observation domain, while the latter estimates the ionosphere effects using uncombined and undifferenced observations, i.e., so-called raw observations. These traditional techniques do not fix carrier-phase ambiguities to integers, if the additional corrections of satellite hardware biases are not provided to the users. To derive the corrections of hardware biases in network side, the ionosphere-free combination operation is often used to obtain the ionosphere-free ambiguities from the L1 and L2 ones produced even with the raw observation approach in earlier studies. This contribution introduces a variant of the raw observation approach that does not use any ionosphere-free (or narrow-lane) combination operator to derive satellite hardware bias and compute PPP ambiguity float and fixed solution. The reparameterization and the manipulation of design matrix coefficients are described. A computational procedure is developed to derive the satellite hardware biases on WL and L1 directly. The PPP ambiguity-fixed solutions are obtained also directly with WL/L1 integer ambiguity resolutions. The proposed method is applied to process the data of a GNSS network covering a large part of China. We produce the satellite biases of BeiDou, GPS and Galileo. The results demonstrate that both accuracy and convergence are significantly improved with integer ambiguity resolution. The BeiDou contributions on accuracy and convergence are also assessed. It is disclosed for the first time that BeiDou only ambiguity-fixed solutions achieve the similar accuracy with that of GPS/Galileo combined, at least in mainland China. The numerical analysis demonstrates that the best solutions are achieved by GPS/Galileo/BeiDou solutions. The accuracy in horizontal components is better than 6 mm, and in the height component better than 20 mm (one sigma). The mean convergence time for reliable ambiguity-fixing is about 1.37 min with 0.12 min standard deviation among stations without using ionosphere corrections and the third frequency measurements. The contribution of BDS is numerically highlighted.
Symptom remission and functional outcome in an Egyptian sample of patients with schizophrenia
Authors: El Ghamry Reem , Saad Ahmed , Elbatrawy Amira Nassieb , Hassan Ghada A. M. , Rabie Eman S. , Mohamed Mohamed Youssef 
Published: December 2021

Abstract
Background
The ultimate treatment goal of schizophrenia is regaining patients’ pre-morbid function.

Results
Ninety-three outpatients with schizophrenia, diagnosed according to the criteria of Diagnostic and Statistical Manual of Mental Disorders—fourth edition (DSM-IV), were recruited, of whom 35 patients (37.6%) had achieved the remission severity criteria, whereas 58 patients (62.4%) failed to fulfill the criteria for remission. The functional aspects were examined by the Global Assessment of Functioning scale (GAF) and the Social Functioning Questionnaire (SFQ). Predictors of outcome were examined by applying binary logistic regression analysis. Patients who fulfilled those specific criteria for remission showed a favorable outcome in the assessed areas, regarding GAF and social functioning in society. Lack of judgment or insight item of PANSS showed significantly good functional outcomes.

Conclusion
The results suggest that the remission concept has important implications for the treatment of schizophrenia. Remission seems to be associated with better functional capabilities. However, this does not necessarily mean that remitted patients have “adequate” functioning, especially regarding the social skills domain.
Resuming post living donor liver transplantation in the COVID-19 pandemic: real-life experience, single-center experience
Authors: Abdellatif Abeer Awad , Mogawer Mohamad Sherif , El- Shazli Mostafa , El-Karaksy Hanaa , Salah Ayman , Abdel-Maqsod Amany , El-Amir Mona , Said Mohamed , Zayed Naglaa , Hosny Karim , Eldeen Hadeel Gamal , Osman Ayman M. A. , Mansour Doaa A. , Nabil Ahmed , Abdel-Ghani Ahmed , Mogahed Engy A. , Yasin Noha A. 
Published: December 2021

Abstract
Background
Solid organ transplantation (SOT) service has been disrupted during the current coronavirus disease 2019 (COVID-19) pandemic, which deferred the service in most centers worldwide. As the pandemic persists, there will be an urgency to identify the best and safest practices for resuming activities as areas re-open. Resuming activity is a difficult issue, in particular, the decision of reopening after a period of slowing down or complete cessation of activities.

Objectives
To share our experience in resuming living donor liver transplantation (LDLT) in the context of the COVID-19 pandemic in the Liver Transplantation Unit of El-Manial Specialized Hospital, Cairo University, Egypt, and to review the obstacles that we have faced.

Material and methods
This study is a single-center study. We resumed LDLT by the 26th of August 2020 after a period of closure from the 1st of March 2020. We have taken a lot of steps in order to prevent COVID-19 transmission among transplant patients and healthcare workers (HCWs).

Results
In our study, we reported three LDLT recipients, once resuming the transplantation till now. All our recipients and donors tested negative for SARS-CoV-2 by nasopharyngeal RT-PCR a day before the transplantation. Unfortunately, one of them developed COVID-19 infection. We managed rapidly to isolate him in a single room, restricting one team of HCWs to deal with him with strict personal protective measures. Finally, the patient improved and was discharged in a good condition. The second patient ran a smooth course apart from FK neurotoxicity which improved with proper management. The third patient experienced a sharp rise in bilirubin and transaminases on day 14 that was attributed to drug toxicity vs. rejection and managed by discontinuing the offending drugs and pulse steroids. In addition, one of our head nurses tested positive for SARS-CoV-2 that was manageable with self-isolation.

Conclusion
Careful patient, donor, personnel screening is mandatory. Adequate supply of personal protective equipments, effective infection control policies, and appropriate administrative modifications are needed for a safe return of LDLT practice.
Construction of a tool for assessment of joint attention in Egyptian Cairene children
Authors: Muhammad Aya Adel , ElFiky Yomna Hassan , Shoeib Rasha Mohammed , Rifaie Nahla Abd El-Aziz , Saleh Marwa Mahmoud 
Published: December 2021

Abstract
Background
Joint attention (JA) is a basic social communicative skill important for language development. JA deficits appear prior to language acquisition. Because autism is often not diagnosed until a child is three or four years of age, it is important to look for indicators prior to language acquisition such as JA to provide appropriate treatment at a younger age. Therefore, the aim of this study is to construct an objective tool for assessment of joint attention skills in young Egyptian children to detect the presence of autistic behaviour in high-risk children in order to conduct plans for early intervention. The questionnaire was constructed to assess the five main components of JA and was termed Egyptian Joint Attention Questionnaire. The questions were formulated in the colloquial Egyptian Arabic language and in an ‘easy-to understand’ design that would be comprehensible by mothers. No question was directly translated from another questionnaire. Ten typically developing (TD) children, with an age range of 18–54 months, were included in the pilot study of the test design. It was applied to 90 TD children and 30 autistic children (contrast group) within the same age range. Participant's responses were statistically analysed to assess the validity and reliability of the questionnaire and to compare the responses related to TD children and autistic children.

Results
There was high internal consistency and reliability of the questionnaire (Cronbach’s α = 0.9, Intra-class correlation = .776), with a statistically significant difference between TD and autistic children (P < 0.001).

Conclusions
The questionnaire is a valid and reliable assessment tool that could be used in early detection of autistic Egyptian children.