bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose-derived mesenchymal stem cells from obese mice prevent body weight gain and hyperglycemia
Authors: Qi Yicheng , Liu Wen , Wang Xiangsheng , Lu Nan , Yang Minglan , Liu Wei , Ma Jing , Liu Wei , Zhang Wenjie , Li Shengxian 
Published: May 2021

AbstractChanges that occur to the stem cell microenvironment with disease are a major consideration that may affect the behavior and potential therapeutic efficacy of mesenchymal stem cells (MSCs). The purpose of this study is to evaluate the effects of adipose-derived MSCs (ADSCs) from obese mice with hyperglycemia on body weight and glucose homeostasis. After 10 weeks of high-fat diet, mice were injected with phosphate-buffered saline (PBS) and ADSCs derived from normal mice (N-ADSCs) or obese mice (O-ADSCs), respectively. Mice fed with standard rodent chow were injected with PBS and served as normal controls. Obese mice treated with O-ADSCs showed less body weight gain than those receiving PBS or N-ADSCs. The mice that received ADSCs, especially O-ADSCs, also showed improvement in obesity-related hyperglycemia. In particular, the inguinal fat was reduced in obese mice receiving O-ADSCs compared with other groups, probably caused by the increased lipolysis of inguinal fat. Moreover, ADSC infusion restored insulin receptor (INSR) expression in the muscle of obese mice. Differential expression of the CD90 surface marker was slightly increased, while monocyte chemoattractant protein 1 (MCP-1) was reduced in O-ADSCs compared to N-ADSCs. These data provide a theoretical basis that autologous ADSCs from obese individuals may be more effective for treating obesity and related hyperglycemia.
Wireless technologies for the connectivity of the future
Authors: Cardoso Filipe D. , Lipovac Vlatko , Correia Luis M. 
Published: May 2021

AbstractThis Special Issue originates from the international conference EuCNC 2020 (European Conference on Networks and Communications), which was planned to be held in June 2020 in Dubrovnik (Croatia), but due to the COVID-19 pandemic was changed to an Online Conference. The Technical Programme Chairs of the conference have selected the best papers and invited authors to submit an extended version of their paper, by at least one third of their length. Only the top ranked papers were invited to this Special Issue, in order to fulfil its purpose. The main target was to collect and present quality research contributions in the most recent activities related to systems and networks beyond 5G, already presenting ideas for 6G. Through this Special Issue, the state-of-the-art is presented and the new challenges are highlighted, regarding the latest advances on systems and network perspectives that are already being positioned beyond 5G, bridging as well with the evolution of 5G, including applications and trials. Therefore, the motivation for this Special Issue is to present the latest and finest results on the evolution of research of mobile and wireless communications, coming, but not exclusively (since EuCNC is a conference open to the whole research community), from projects co-financed by the European Commission within its R&D programmes.
Factors associated with early antenatal care attendance among women in Papua New Guinea: a population‐based cross‐sectional study
Authors: Seidu Abdul-Aziz 
Published: May 2021

Abstract
Background
Early initiation of antenatal care (ANC) is a key component of antenatal care, as suggested by the World Health Organisation (WHO). It helps in early identification and mitigation of adverse pregnancy-related complications. Despite this, a greater proportion of women worldwide still do not adhere to this recommendation. This study, therefore, sought to assess the prevalence and factors associated with early initiation of ANC among women in Papua New Guinea (PNG).

Methods
A population-based cross-sectional study was conducted among 4,274 women using data from the 2016–2018 PNG Demographic and Health Survey (PDHS). The outcome variable was early initiation of ANC. Bivariate (chi-square) and multivariable logistic regression analyses were done and statistical significance was set at p < 0.05.

Results
The prevalence of early ANC initiation was 23.0 % (CI = 20.8–24.6). The binary logistic regression analysis showed that working women had higher odds of early ANC attendance compared with those who were not working [AOR = 1.37, 95 %CI = 1.17 = 1.60]. The results also showed that women from Islands region had lower odds [AOR = 0.50, 95 %CI = 0.40–0.62] of early ANC attendance compared with those from Southern region. Finally, women with parity 3 had lower odds of early ANC attendance compared to those with parity 1[AOR = 0.64,95 % CI = 0.49–0.84].

Conclusions
This study found a relatively low prevalence of early ANC uptake among women in PNG. The factors associated with early ANC attendance were region of residence, parity, and working status of mothers. To increase early ANC uptake, these factors should be considered when designing new policies or reviewing policies and strategies on ANC uptake to help increase ANC attendance, which can help in the reduction of maternal mortality.
Comparison of appropriateness of Nutri-Score and other front-of-pack nutrition labels across a group of Moroccan consumers: awareness, understanding and food choices
Authors: Aguenaou Hassan , El Ammari Laila , Bigdeli Maryam , El Hajjab Amina , Lahmam Houria , Labzizi Saloua , Gamih Hasnae , Talouizte Anouar , Serbouti Chaimae , El Kari Khalid , Benkirane Hasnae , El Berri Hicham , AL-Jawaldeh Ayoub , Yahyane Abdelhakim 
Published: May 2021

Abstract
Background
The front of pack nutrition label Nutri-Score, intended to help consumers orient their choices towards foods that are more favorable to health, was developed in France and applied in several European countries. Consideration is underway for its use in Morocco. This study aims to assess Moroccan consumers’ perception and objective understanding of Nutri-Score and 4 other nutritional information labels (Health Star Rating, Health warning, Reference Intakes and Multiple Trafic Light) and their impact on purchase intentions.

Methods
814 participants were asked to choose among 3 food classes (yoghurts, biscuits and cold cuts), which ones they would prefer to buy among three products with different nutritional profiles and then to rank them according to their nutritional quality. Participants first performed these tasks without a visible nutritional label, and then, after being randomized to one of five labels tested, with the nutritional label visible on front of packs. Next, the full set of tested labels was presented to the participants who were asked a series of questions regarding their preferences, the attractiveness of the labels, their perceptions, intention to use and the trustworthiness placed in the labels.

Results
Compared to the Reference Intake, the Nutri-Score (OR = 2.48 [1.53–4.05], p < 0.0001), was associated with the highest improvement in the ability to correctly classify foods based on their nutritional quality. The percentage of participants who improved their food choice was higher than those who worsened it for all the labels. For yogurts and cookies, the most significant improvements were observed for the Nutri-Score and the Reference Intakes: Concerning the perception of labels, the Nutri-Score is the label that received the highest number of positive responses, whether concerning the ease of being spotted (82.2%), of being understood (74%), and to provide rapid information (68.8%). The Nutri-Score was ranked as the preferred label by 64.9% of the participants.

Conclusion
The Nutri-Score appears to be the most effective nutritional information system to inform consumers about the nutritional quality of foods in Morocco, where it could constitute a useful tool to help consumers in their food choices in situations of purchase.
Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome
Authors: Han Qixin , Wang Juan , Li Weiping , Chen Zi-Jiang , Du Yanzhi 
Published: May 2021

Abstract
Background
The characteristics of polycystic ovary syndrome (PCOS), a common reproductive endocrinal disorder, are high incidence, complicated aetiology and poor therapeutic effects. PCOS patients frequently exhibit gut dysbiosis; however, its roles in the regulation of metabolic and endocrinal balances in PCOS pathophysiology are not clear.

Results
In this study, gut dysbiosis was reproduced in dehydroepiandrosterone (DHEA)-induced PCOS-like rats. An antibiotic cocktail was used to eliminate gut microbiota during DHEA treatment; however, depletion of the gut microbiota did not prevent the occurrence of PCOS phenotypes in DHEA-treated rats. DHEA-shaped gut microbiota transplanted to pseudo germ-free recipients trigged disturbances in hepatic glucolipid metabolism and reproductive hormone imbalance. The clinical features of PCOS may be correlated with the relative abundance of gut microbes and the levels of faecal metabolites in faecal microbiota transplantation (FMT) recipient rats.

Conclusion
These findings indicate that androgen-induced gut microbiota dysbiosis may aggravate metabolic and endocrinal malfunction in PCOS.
Towards enhancing coral heat tolerance: a “microbiome transplantation” treatment using inoculations of homogenized coral tissues
Authors: Doering Talisa , Wall Marlene , Putchim Lalita , Rattanawongwan Tipwimon , Schroeder Roman , Hentschel Ute , Roik Anna 
Published: May 2021

AbstractBackgroundMicrobiome manipulation could enhance heat tolerance and help corals survive the pressures of ocean warming. We conducted coral microbiome transplantation (CMT) experiments using the reef-building corals,PocilloporaandPorites, and investigated whether this technique can benefit coral heat resistance while modifying the bacterial microbiome. Initially, heat-tolerant donors were identified in the wild. We then used fresh homogenates made from coral donor tissues to inoculate conspecific, heat-susceptible recipients and documented their bleaching responses and microbiomes by 16S rRNA gene metabarcoding.ResultsRecipients of both coral species bleached at lower rates compared to the control group when exposed to short-term heat stress (34 °C). One hundred twelve (Pocilloporasp.) and sixteen (Poritessp.) donor-specific bacterial species were identified in the microbiomes of recipients indicating transmission of bacteria. The amplicon sequence variants of the majority of these transmitted bacteria belonged to known, putatively symbiotic bacterial taxa of corals and were linked to the observed beneficial effect on the coral stress response. Microbiome dynamics in our experiments support the notion that microbiome community evenness and dominance of one or few bacterial species, rather than host-species identity, were drivers for microbiome stability in a holobiont context.ConclusionsOur results suggest that coral recipients likely favor the uptake of putative bacterial symbionts, recommending to include these taxonomic groups in future coral probiotics screening efforts. Our study suggests a scenario where these donor-specific bacterial symbionts might have been more efficient in supporting the recipients to resist heat stress compared to the native symbionts present in the control group. These findings urgently call for further experimental investigation of the mechanisms of action underlying the beneficial effect of CMT and for field-based long-term studies testing the persistence of the effect.
Psychotherapists’ emotional reactions to patients’ personality trait in personality disorder treatment settings: an exploratory study
Authors: Cavalera Cesare , Boldrini Annalisa , Merelli Alessia Antonella , Squillari Edoardo , Politi Pierluigi , Pagnini Francesco , Oasi Osmano 
Published: May 2021

AbstractBackgroundTherapist’s emotional reactions toward patients in clinical facilities are a key concept in the treatment of personality disorders. Considering only clinical settings specialized in treatment of personality pathology the present paper aimed at: (1) assessing any direct relationship between patient symptom severity and therapist emotional response; (2) exploring patients’ functioning configurations that can be associated with specific therapist reactions (3) investigating whether these relationships remains significant when accounting for other setting variables related to patients or therapist.MethodsThe present study included 43 outpatients with personality disorders who underwent a psychotherapy treatment in two Italian facilities dedicated to outpatients with personality disorders and their 19 psychotherapists. The Symptom Checklist-90-Revised (SCL-90R) was used to explore clinical severity condition. Psychotherapists completed the Therapist Response Questionnaire (TRQ) to identify pattern of therapists’ response and the Shedler-Westen Assessment Procedure-200 (SWAP-200) in order to assess personality traits of the patients.ResultsNo significant relationship between the clinical severity of the symptoms and the therapist’ responses was found. Even when controlled for clinical severity condition, duration of the treatment, age and educational level of the patient or years of therapist experience, most of SWAP-200 traits appeared to be significant predictors of therapist’ emotional responses.ConclusionsThe present study confirms the value of therapists’ emotional response as a useful tool in understanding psychological processes related to clinical practice highlighting its context-dependent dimension.
Tumor reversion: a dream or a reality
Authors: Tripathi Avantika , Kashyap Anjali , Tripathi Greesham , Yadav Joni , Bibban Rakhi , Aggarwal Nikita , Thakur Kulbhushan , Chhokar Arun , Jadli Mohit , Sah Ashok Kumar , Verma Yeshvandra , Zayed Hatem , Husain Amjad , Bharti Alok Chandra , Kashyap Manoj Kumar 
Published: May 2021

AbstractReversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative RNA splicing, post-transcriptional, post-translational modifications, availability of proteomics, genomics editing tools, and chemical biology approaches gave hope to manipulation of cancer cells reversion to a normal cell phenotype as evidences are subtle but definitive. Regardless of the advancement, there is a long way to go, as customized techniques are required to be fine-tuned with precision to attain more insights into tumor reversion. Tumor regression models using available genome-editing methods, followed by in vitro and in vivo proteomics profiling techniques show early evidence. This review summarizes tumor reversion developments, present issues, and unaddressed challenges that remained in the uncharted territory to modulate cellular machinery for tumor reversion towards therapeutic purposes successfully. Ongoing research reaffirms the potential promises of understanding the mechanism of tumor reversion and required refinement that is warranted in vitro and in vivo models of tumor reversion, and the potential translation of these into cancer therapy. Furthermore, therapeutic compounds were reported to induce phenotypic changes in cancer cells into normal cells, which will contribute in understanding the mechanism of tumor reversion. Altogether, the efforts collectively suggest that tumor reversion will likely reveal a new wave of therapeutic discoveries that will significantly impact clinical practice in cancer therapy.
Current and emerging therapies for primary central nervous system lymphoma
Authors: Yuan Yan , Ding Tianling , Wang Shu , Chen Hong , Mao Ying , Chen Tong 
Published: May 2021

AbstractPrimary central nervous system (CNS) lymphoma (PCNSL) is a rare type of extranodal lymphoma exclusively involving the CNS at the onset, with diffuse large B-cell lymphoma (DLBCL) as the most common histological subtype. As PCNSL is a malignancy arising in an immune-privileged site, suboptimal delivery of systemic agents into tumor tissues results in poorer outcomes in PCNSL than in non-CNS DLBCLs. Commonly used regimens for PCNSL include high-dose methotrexate-based chemotherapy with rituximab for induction therapy and intensive chemotherapy followed by autologous hematopoietic stem cell transplantation or whole-brain radiotherapy for consolidation therapy. Targeted agents against the B-cell receptor signaling pathway, microenvironment immunomodulation and blood-brain barrier (BBB) permeabilization appear to be promising in treating refractory/relapsed patients. Chimeric antigen receptor-T cells (CAR-T cells) have been shown to penetrate the BBB as a potential tool to manipulate this disease entity while controlling CAR-T cell-related encephalopathy syndrome. Future approaches may stratify patients according to age, performance status, molecular biomarkers and cellular bioinformation. This review summarizes the current therapies and emerging agents in clinical development for PCNSL treatment.
Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies
Authors: Iyer Deepak Narayanan , Faruq Omar , Zhang Lun , Rastgoo Nasrin , Liu Aijun , Chang Hong 
Published: May 2021

AbstractThe myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the crossroads of multiple signaling pathways that govern several critical operations in normal and malignant cellular physiology. Functioning as a target of protein kinase C, MARCKS shuttles between the phosphorylated cytosolic form and the unphosphorylated plasma membrane-bound states whilst regulating several molecular partners including, but not limited to calmodulin, actin, phosphatidylinositol-4,5-bisphosphate, and phosphoinositide-3-kinase. As a result of these interactions, MARCKS directly or indirectly modulates a host of cellular functions, primarily including cytoskeletal reorganization, membrane trafficking, cell secretion, inflammatory response, cell migration, and mitosis. Recent evidence indicates that dysregulated expression of MARCKS is associated with the development and progression of hematological cancers. While it is understood that MARCKS impacts the overall carcinogenesis as well as plays a part in determining the disease outcome in blood cancers, we are still at an early stage of interpreting the pathophysiological roles of MARCKS in neoplastic disease. The situation is further complicated by contradictory reports regarding the role of phosphorylated versus an unphosphorylated form of MARCKS as an oncogene versus tumor suppressor in blood cancers. In this review, we will investigate the current body of knowledge and evolving concepts of the physical properties, molecular network, functional attributes, and the likely pathogenic roles of MARCKS in hematological malignancies. Key emphasis will also be laid upon understanding the novel mechanisms by which MARCKS determines the overall disease prognosis by playing a vital role in the induction of therapeutic resistance. Additionally, we will highlight the importance of MARCKS as a valuable therapeutic target in blood cancers and will discuss the potential of existing strategies available to tackle MARCKS-driven blood cancers.
Different dimensions of teacher and peer assessment of EFL learners’ writing: descriptive and narrative genres in focus
Authors: Pourdana Natasha , Asghari Soheila 
Published: May 2021

AbstractThe present study explored the extent to which teacher assessment (TA) and peer assessment (PA) differ in terms of magnitude and patterns of distribution across English as a Foreign Language (EFL) learners’ descriptive and narrative writing performance. Twenty Persian-speaking EFL learners were non-randomly selected and voluntarily participated in a 12-session writing course at a private language school in Iran. Their performance on descriptive and narrative writing tasks was subjected to PA and TA sequentially. The West Virginia Department of Education descriptive writing rubric (with five components of organization, development, sentence structure, word choice and grammar, and mechanics) and Smarter Balanced narrative writing rubric (with five categories of narrative focus, organization, elaboration of narrative, language and vocabulary, and conventions) were adopted to schematize and analyze the distribution of the TA and PA comments. The results of frequency analysis indicated that TA far outnumbered PA on both descriptive and narrative genres of writing. Furthermore, on both descriptive and narrative writings, TA and PA commentaries were local in scope, form-focused, fluctuating, and inconsistent. Also, the distribution of TA and PA comments mainly focused on the conventions of narrative writings, while other macro-components of narrative writing had a steady and depleted pattern. The statistical results confirmed the significance of the observed differences between the number and the nature of TA and PA on descriptive and narrative genres of writing. The researchers made their concluding remarks on the probable causes of observed diversities, imposed limitations of the study, and a number of topics for future research.
Complex tsunami hazards in eastern Indonesia from seismic and non-seismic sources: Deterministic modelling based on historical and modern data
Authors: Pranantyo Ignatius R. , Heidarzadeh Mohammad , Cummins Phil R. 
Published: May 2021

AbstractEastern Indonesia is one of the world’s most complex regions in terms of tsunami hazards, as it accommodates numerous seismic and non-seismic tsunami sources with a history of deadly tsunamis. This study is an effort to enhance tsunami hazard knowledge in eastern Indonesia where limited data and analyses exist. We provide a brief understanding of eastern Indonesia’s tsunami hazards by modelling selected deterministic tsunami scenarios from tectonic, submarine mass failure (SMF), and volcanic sources. To our knowledge, this is the first time that tsunami hazards modelling from such diverse sources in Indonesia has been performed. Our methodology is a deterministic tsunami hazard analysis considering credible tsunami sources from historical and contemporary data, modelling them using state-of-the-art simulation tools. We modelled two Mw7.8 tsunamigenic earthquake scenarios on the Flores back-arc thrust, one rupturing the basal fault (FBT-BF) and the other rupturing the splay fault (FBT-SF), showing that the two scenarios produce maximum tsunami amplitudes of$$\sim$$∼5.3 m and$$\sim$$∼4.2 m, respectively, which are comparable to the deadly 1992 Flores tsunami. We modelled potential SMF-generated tsunamis in the Makassar Strait with SMF volumes of 5$$\hbox {km}^3$$km3and 225$$\hbox {km}^3$$km3which yielded maximum tsunami heights of$$\sim$$∼1.1 m and$$\sim$$∼4.3 m along the eastern coast of Kalimantan Island and$$\sim$$∼2.9 m and$$\sim$$∼11.1 m along the west shore of Sulawesi Island, respectively. The 1871 Ruang volcanic tsunami is studied through existing historical documents and a source model is proposed comprising a flank collapse with volume of$$0.10\ \mathrm{km}^3$$0.10km3. Such a source model successfully reproduced the 25 m runup reported in a historical account.