bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in microstructure and wear-resistance of high chromium cast iron/medium carbon steel bimetal with high vanadium
Authors: Li Xuejun , Liu Ying , Zhou Tingchuan 
Published: January 2021

Abstract
In the present study, a high chromium cast iron (HCCI) with high content of vanadium (15 wt.%) as the wear resistance layer was fabricated on the medium carbon steel (MCS) substrate by laser cladding process. The effect of high vanadium addition on microstructure, phase, hardness and wear properties of bimetal were investigated. The results show that the microstructure of HCCI layer was significantly improved and refined with addition of high vanadium. No defect such as microcracks and unbonded regions was observed on the interface of the bimetal. The x-ray diffraction revealed that the HCCI (15 wt.% V) layer consists of α-Fe matrix, (Cr, Fe)7C3 and VC carbides. The SEM images shown that round-like VC particles uniformly distributed on the α-Fe matrix and (Cr, Fe)7C3 are of rod-like with distributed on grain boundary, such micromorphology makes it have higher hardness (883HV) and excellent wear resistance than HCCI layer without vanadium addition.
Selective laser melting of 1.2738 mold steel: densification, microstructure and microhardness
Authors: Yang Wei , Zhang Xiaoxun , Ma Fang , Dong Sensen , Jiang Juze 
Published: January 2021

Abstract
In this study, the effects of laser power and scanning speed on the relative density, microstructure and microhardness of selectively laser melted (SLM) 1.2738 mold steel were systematically investigated. The deposited energy density, which can express the change in these process parameters and the relative density with one curve, were found more reliable than volume energy density (VED) on the design of process parameters. With the same VED value, samples formed by the combination of a high laser power and scanning speed possess a higher densification than that formed by low laser power and scanning speed. High power may lead to keyhole pore formation. In the top of the molten pool, ultrafine cellular structure was formed, causing that the microhardness value of the top section was always higher than that of the side section.
Measurement of time-varying electron density of the plasma generated from a small-size cylindrical RDX explosion by Rayleigh microwave scattering
Authors: CHEN Hong , PAN Xuchao , HE Yong , JIAO Junjie , SHEN Jie , BEN Chi 
Published: January 2021

Abstract
It is challenging to measure the electron density of the unsteady plasma formed by charged particles generated from explosions in the air, because it is transient and on a microsecond time scale. In this study, the time-varying electron density of the plasma generated from a small cylindrical cyclotrimethylenetrinitramine (RDX) explosion in air was measured, based on the principle of microwave Rayleigh scattering. It was found that the evolution of the electron density is related to the diffusion of the detonation products. The application of the Rayleigh microwave scattering principle is an attempt to estimate the electron density in explosively generated plasma. Using the equivalent radius and length of the detonation products in the bright areas of images taken by a high-speed framing camera, the electron density was determined to be of the order of 1020 m−3. The delay time between the initiation time and the start of variation in the electron-density curve was 2.77–6.93 μs. In the time-varying Rayleigh microwave scattering signal curve of the explosively generated plasma, the electron density had two fluctuation processes. The durations of the first stage and the second stage were 11.32 μs and 19.20 μs, respectively. Both fluctuation processes increased rapidly to a peak value and then rapidly attenuated with time. This revealed the movement characteristics of the charged particles during the explosion.
Entangling the vibrational modes of two massive ferromagnetic spheres using cavity magnomechanics
Authors: Li Jie , Gröblacher Simon 
Published: January 2021

Abstract
We present a scheme to entangle the vibrational phonon modes of two massive ferromagnetic spheres in a dual-cavity magnomechanical system. In each cavity, a microwave cavity mode couples to a magnon mode (spin wave) via the magnetic dipole interaction, and the latter further couples to a deformation phonon mode of the ferromagnetic sphere via a nonlinear magnetostrictive interaction. We show that by directly driving the magnon mode with a red-detuned microwave field to activate the magnomechanical anti-Stokes process a cavity–magnon–phonon state-swap interaction can be realized. Therefore, if the two cavities are further driven by a two-mode squeezed vacuum field, the quantum correlation of the driving fields is successively transferred to the two magnon modes and subsequently to the two phonon modes, i.e., the two ferromagnetic spheres become remotely entangled. Our work demonstrates that cavity magnomechanical systems allow to prepare quantum entangled states at a more massive scale than currently possible with other schemes.
Arbitrary amplitude ion acoustic double layer in plasma with k-distributed electrons and negative ions
Authors: Kumar Kishan , Mishra M K 
Published: January 2021

Abstract
In this paper we have discussed the consequence of superthermal electrons and negative ion concentration on the arbitrary amplitude ion-acoustic double layers (IA-DLs) for plasma comprising the hot negative and positive ions with kappa distribution electrons. The energy equation is deduced for ion acoustic waves using Pseudo potential technique. We have investigated different parametric regimes for the existence of rarefactive and compressive ion acoustic DLs. The existence of double layers in term of minimum and maximum Mach number has calculated numerically. The effect of spectral index k on the amplitude of DLs and depth of Sagdeev potential has been discussed in detail. From numerical analysis, it is found that the compressive DLs exist at low values of α and rarefactive double layer exist at higher values of α. On the other hand, the effect of ionic temperature ratio (σ
1 and σ
2) plays significant role for the formation of double layer. Our analytical work also shows that the system supports coexistence of compressive and rarefactive DLs. It is also observed that the mass ratio

μ

affect the basic properties of DLs. We expect that the present results may be used to explain the ion-acoustic double layer in space plasma, where two ionic species and superthermal electrons are observed NO52.35g.
Elevated performance of binder-free Co3O4electrode for the supercapacitor applications
Authors: Sharma Meenakshi , Adalati Ravikant , Kumar Ashwani , Chawla Vipin , Chandra Ramesh 
Published: January 2021

AbstractIn the present work, we have designed a symmetric supercapacitor (SS) device by synthesizing a pseudocapacitive binder-free cobalt oxide (Co3O4) thin film based electrode using reactive DC magnetron sputtering technique. The thin film electrodes were characterized by x-ray diffraction, Raman spectroscopy and x-ray photoelectron spectroscopy to reveal the crystallographic details, stoichiometry, and electronic configuration, respectively. Furthermore, Co3O4thin film electrode is used for pseudocapacitor and electrochemically tested in 1M aqueous KOH electrolyte solution, in addition, a symmetric supercapacitor (SS) device was fabricated. It was found that the SS device exhibits tremendous electrochemical stability in terms of high capacitance and good cycling stability. The value of specific capacitance for Co3O4thin film electrodes and the SS device was calculated to be 392 Fg−1and 95 Fg−1, respectively, at a scan rate of 2 mAcm−2. The SS device exhibits high specific energy (29 W-hkg−1) along with comparable good specific power (4745 Wkg−1). In this work, the fabricated SS device demonstrates 91.40% cyclic and capacitance retention at 8 mAcm−2beyond 10 000 cycles. The excellent electrochemical stability and capacitive performance of the SS device suggest that it would be an ideal and potential candidate for energy storage applications in the future.
Biocompatibility assessment of silver chloride nanoparticles derived from Padina gymnospora and its therapeutic potential
Authors: Rajagopal Gopalan , Manivannan Nanthagopal , Sundararajan Mahalingam , Kumar Arumugam Ganesh , Senthilkumar Samuthirarajan , Mathivanan Narayanasamy , Ilango Sakkanan 
Published: January 2021

Abstract
The objective of the present work was to improve the biological activity of Padina gymnospora. In the current study, silver chloride nanoparticles have been synthesized using the aqueous extract of Padina gymnospora and further characterized by ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, x-ray powder diffraction, scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy and atomic force microscope. Further, the hemolytic activity and eco-toxicity of silver chloride nanoparticles analyzed. The synthesized silver chloride nanoparticles were found to be mono-dispersed and spherical with an average size of 11.5–32.86 nm. The particles showed an anticancer effect in a dose-dependent manner against breast cancer cell line (MCF-7 cell lines) (IC50 = 31.37 μg ml−1). In addition, it showed the larvicidal activity against Aedes aegypti at a lower dose (3.92 μg ml−1) than that of the aqueous extract (13.01 μg ml−1). Nanoparticles also exhibited greater antimicrobial activity for both bacterial and fungal pathogens. The synthesized silver chloride nanoparticles showed a maximum zone of inhibition, i.e., 31 mm for Candida albicans followed and 27 mm for vancomycin resistance Enterococcus faecalis.The results suggest the possible use of synthesized silver nanoparticles with P. gymnospora as therapeutic agent for breast cancer, dengue vector control and as antimicrobial agent.
PRISA: a user-friendly software for determining refractive index, extinction co-efficient, dispersion energy, band gap, and thickness of semiconductor and dielectric thin films
Authors: Jena S , Tokas R B , Thakur S , Udupa D V 
Published: January 2021

Abstract
A user-friendly software PRISA has been developed to determine optical constants (refractive index and extinction co-efficient), dispersion parameters (oscillator energy and dispersion energy), absorption co-efficient, band gap and thickness of semiconductor and dielectric thin films from measured transmission spectrum, only. The thickness, refractive index, and extinction co-efficient of the films have been derived using Envelope method proposed by Swanepoel. The absorption co-efficient in the strong absorption region is calculated using the method proposed by Connel and Lewis. Subsequently, both direct and indirect bandgap of the films is estimated from the absorption co-efficient spectrum using Tauc plot. The software codes are written in Python and the graphical user interface is programmed with tkinter package of Python. It provides convenient input and output of the measured and derived data. The software has a feature to cross check the results by retrieving transmission spectrum using the values of refractive index, extinction co-efficient, and thickness obtained from Envelope method. The performance of the software is verified by analyzing numerically generated transmission spectra of a-Si:H amorphous semiconductor thin films, and experimentally measured transmission spectra of electron beam evaporated HfO2 dielectric thin films as examples. PRISA is found to be much simpler and accurate as compared to the other freely available softwares. To help researchers working on thin films, the software is made freely available at https://www.shuvendujena.tk/download.
lgpr:an interpretable non-parametric method for inferring covariate effects from longitudinal data
Authors: Timonen Juho , Mannerström Henrik , Vehtari Aki , Lähdesmäki Harri 
Published: January 2021

AbstractMotivationLongitudinal study designs are indispensable for studying disease progression. Inferring covariate effects from longitudinal data, however, requires interpretable methods that can model complicated covariance structures and detect non-linear effects of both categorical and continuous covariates, as well as their interactions. Detecting disease effects is hindered by the fact that they often occur rapidly near the disease initiation time, and this time point cannot be exactly observed. An additional challenge is that the effect magnitude can be heterogeneous over the subjects.ResultsWe present lgpr, a widely applicable and interpretable method for non-parametric analysis of longitudinal data using additive Gaussian processes. We demonstrate that it outperforms previous approaches in identifying the relevant categorical and continuous covariates in various settings. Furthermore, it implements important novel features, including the ability to account for the heterogeneity of covariate effects, their temporal uncertainty, and appropriate observation models for different types of biomedical data. The lgpr tool is implemented as a comprehensive and user-friendly R-package.Availability and implementationlgpr is available at jtimonen.github.io/lgpr-usage with documentation, tutorials, test data and code for reproducing the experiments of this article.Supplementary informationSupplementary data are available at Bioinformatics online.
The Limits of the City: Atmospheres of Lockdown
Authors: Young Alison 
Published: January 2021

Abstract
Criminological engagement with urban environments has burgeoned, including investigations into the criminological sense of place and into the atmospheres of crime and justice. This article analyses cities under lockdown in the 2020 COVID-19 pandemic. Used in numerous cities, lockdowns conjoin public health initiatives and crime control to restrict the location and activities of citizens. Drawing on textual and ethnographic exploration of lockdown in Melbourne, Australia, the article examines how we make meaning in lockdown through processes of sensory and spatial interpretation. Such an approach exposes both atmospheres of control, through the criminalization of everyday activities, and numerous instances of subversion through resistance to and adaptation of the spatial and sensorial characteristics of lockdown. The article argues for the importance of the sensory as a means of conceptualizing, repopulating and redesigning future cities after lockdown ends.
Epidemiology of Invasive Escherichia coli Infection and Antibiotic Resistance Status Among Patients Treated in US Hospitals: 2009–2016
Authors: Begier Elizabeth , Rosenthal Ning A , Gurtman Alejandra , Kartashov Alex , Donald Robert G K , Lockhart Stephen P 
Published: January 2021

Abstract

Background
Published data is limited on the prevalence and risk of recurrence of extraintestinal invasive Escherichia coli infections (IEIs) in the United States.

Methods
The analysis included all inpatient and hospital-based outpatient visits occurring between 2009 and 2016 at hospitals with continuous microbiology data submission to the Premier Healthcare Database for 90 days before and 12 months after the admission or visit. IEI was defined as having positive E. coli culture from a normally sterile site (eg, blood, cerebrospinal fluid). The prevalence of IEI, 12-month risk of recurrent IEI, and antibiotic resistance were assessed.

Results
Overall, 144 944 725 hospital visits among 37 207 510 patients were analyzed, and 71 909 IEI events occurred in 67 583 patients, corresponding to an IEI prevalence of 0.50 events per 1000 visits and 1.82 events per 1000 patients. Recurrence was common: 26.9 per 1000 patients had a recurrent IEI in the 12 months after their infection. Most infections were community acquired (66.4%), and urosepsis was most common clinical syndrome (66.0%). The 30-day risk of IEI among patients undergoing transrectal ultrasound–guided prostate biopsy was high: 5.03 events per 1000 patients. Among all IEI cases with antibiotic susceptibility testing, 9.18% were resistant to extended-spectrum cephalosporins, 28.22% to fluoroquinolones, and 0.14% to carbapenems. Resistance to extended-spectrum cephalosporins increased from 5.46% to 12.97% during the 8-year study period.

Conclusions
This real-world study indicates a substantial burden of IEI and recurrent IEI exists in the United States, as well as increasing resistance to extended-spectrum cephalosporins. Future research should explore risk factors of recurrent IEI aiming to effectively prevent such infections.
The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis
Authors: Badimon Lina , Vilahur Gemma , Rocca Bianca , Patrono Carlo 
Published: January 2021

AbstractArachidonic acid is one of the most abundant and ubiquitous ω-6 polyunsaturated fatty acid, present in esterified form in the membrane phospholipids of all mammalian cells and released from phospholipids by several phospholipases in response to various activating or inhibitory stimuli. Arachidonic acid is the precursor of a large number of enzymatically and non-enzymatically derived, biologically active autacoids, including prostaglandins (PGs), thromboxane (TX) A2, leukotrienes, and epoxyeicosatetraenoic acids (collectively called eicosanoids), endocannabinoids and isoprostanes, respectively. Eicosanoids are local modulators of the physiological functions and pathophysiological roles of blood vessels and platelets. For example, the importance of cyclooxygenase (COX)-1-derived TXA2 from activated platelets in contributing to primary haemostasis and atherothrombosis is demonstrated in animal and human models by the bleeding complications and cardioprotective effects associated with low-dose aspirin, a selective inhibitor of platelet COX-1. The relevance of vascular COX-2-derived prostacyclin (PGI2) in endothelial thromboresistance and atheroprotection is clearly shown by animal and human models and by the adverse cardiovascular effects exerted by COX-2 inhibitors in humans. A vast array of arachidonic acid-transforming enzymes, downstream synthases and isomerases, transmembrane receptors, and specificity in their tissue expression make arachidonic acid metabolism a fine-tuning system of vascular health and disease. Its pharmacological regulation is central in human cardiovascular diseases, as demonstrated by biochemical measurements and intervention trials.
Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development
Authors: Derrick Christopher J , Sánchez-Posada Juliana , Hussein Farah , Tessadori Federico , Pollitt Eric J G , Savage Aaron M , Wilkinson Robert N , Chico Timothy J , van Eeden Fredericus J , Bakkers Jeroen , Noël Emily S 
Published: January 2021

AbstractAimsVertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionalized cellular changes. While previous studies have demonstrated broad requirements for extracellular matrix (ECM) components in cardiac morphogenesis, we hypothesized that ECM regionalization may fine tune cardiac shape during heart development.Methods and resultsUsing live in vivo light sheet imaging of zebrafish embryos, we describe a left-sided expansion of the ECM between the myocardium and endocardium prior to the onset of heart looping and chamber ballooning. Analysis using an ECM sensor revealed the cardiac ECM is further regionalized along the atrioventricular axis. Spatial transcriptomic analysis of gene expression in the heart tube identified candidate genes that may drive ECM expansion. This approach identified regionalized expression of hapln1a, encoding an ECM cross-linking protein. Validation of transcriptomic data by in situ hybridization confirmed regionalized hapln1a expression in the heart, with highest levels of expression in the future atrium and on the left side of the tube, overlapping with the observed ECM expansion. Analysis of CRISPR-Cas9-generated hapln1a mutants revealed a reduction in atrial size and reduced chamber ballooning. Loss-of-function analysis demonstrated that ECM expansion is dependent upon Hapln1a, together supporting a role for Hapln1a in regionalized ECM modulation and cardiac morphogenesis. Analysis of hapln1a expression in zebrafish mutants with randomized or absent embryonic left–right asymmetry revealed that laterality cues position hapln1a-expressing cells asymmetrically in the left side of the heart tube.ConclusionWe identify a regionalized ECM expansion in the heart tube which promotes correct heart development, and propose a novel model whereby embryonic laterality cues orient the axis of ECM asymmetry in the heart, suggesting these two pathways interact to promote robust cardiac morphogenesis.
Narratives of Displacement: On Embodied Experience of Migration in Ulitskaya, Lindén, and Palei
Authors: Sorvari Marja 
Published: January 2021

AbstractThis essay discusses representations of migrant experiences of displacement by Russian women writers Liudmila Ulitskaya, Zinaida Lindén, and Marina Palei. The theoretical approach is guided by feminist geography and narrative studies, with attention to the conceptualization of space and place through embodied everyday experiences. The authors represent different writerly positions with which today’s Russophone writers engage, including multilingual and multilocal trends in and outside post-Soviet Russia. Although Lindén and Palei reside outside and Ulitskaya in Russia, their texts address (post-)Soviet migration and displacement, bringing critical perspectives both to their new home countries and to their homeland, Russia. In each text literary figures question and/or oppose the colonizing histories of their homeland and rewrite their personal stories in the form of narratives of displacement.
Modulation of the Gut Microbiota-farnesoid X Receptor Axis Improves Deoxycholic Acid-induced Intestinal Inflammation in Mice
Authors: Xu Mengque , Shen Yuqin , Cen Mengsha , Zhu Yubin , Cheng Fangli , Tang Linlin , Zheng Xia , Kim John J , Dai Ning , Hu Weiling 
Published: January 2021

Abstract

Background and Aims
Inflammatory bowel disease (IBD) is associated with gut dysbiosis and dysregulation of bile acid metabolism. A high luminal content of deoxycholic acid (DCA) with consumption of a Westernised diet is implicated in the pathogenesis of IBD. The aim of the study is to explore the role of intestinal microbiota and bile acid metabolism in mice with DCA-induced intestinal inflammation.

Methods
Wild-type C57BL mice, 4 weeks old, were fed with AIN-93G (control diet), AIN-93G+0.2% DCA, AIN-93G+0.2% DCA+6 weeks of fexaramine (FXR agonist), or AIN-93G+0.2% DCA+antibiotic cocktail, for 24 weeks. Histopathology, western blotting, and qPCR were performed on the intestinal tissue. Faecal microbiota was analysed by 16S rDNA sequencing. Faecal bile acid and short chain fatty acid (SCFA) levels were analysed by chromatography.

Results
Gut dysbiosis and enlarged bile acid pool were observed in DCA-treated mice, accompanied by a lower farnesoid X receptor (FXR) activity in the intestine. Administration of fexaramine mitigated DCA-induced intestinal injury, restored intestinal FXR activity, activated fibroblast growth factor 15, and normalised bile acid metabolism. Furthermore, fexaramine administration increased the abundance of SCFA-producing bacteria. Depletion of the commensal microbiota with antibiotics decreased the diversity of the intestinal microbiota, attenuated bile acid synthesis, and reduced intestinal inflammation induced by DCA.

Conclusions
DCA induced-intestinal inflammation is associated with alterations of gut microbiota and bile acid profiles. Interventions targeting the gut microbiota-FXR signalling pathway may reduce DCA-induced intestinal disease.