bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of denosumab in gastrointestinal cancer patients receiving short-term periodic steroid premedication for prevention of chemotherapy-induced nausea and vomiting (ESPRESSO-02/HGCSG1602).
Authors: Nakamura Michio , Muranaka Tetsuhito , Yagisawa Masataka , Kawamoto Yasuyuki , Satoshi Yuki , Ishiguro Atsushi , Dazai Masayoshi , Kobayashi Yoshimitsu , Sogabe Susumu , Harada Kazuaki , Sawada Kentaro , Miyagishima Takuto , Tsuji Yasushi , Kikuchi Yasuka , Komatsu Yoshito 
Published: November 2021

Abstract
Purpose
We previously reported that the periodic premedication of glucocorticoids during chemotherapy for gastrointestinal cancer (GIC) caused the reduction of bone mineral densities (BMD) (ESPRESSO-01). We conducted this study to evaluate the efficacy and safety of denosumab in the prevention of chemotherapy-induced decreased BMD.
Methods
Forty-two Japanese patients were studied. Denosumab was administered as a single 60 mg subcutaneous injection before the start of chemotherapy. The primary endpoint was BMD change in the lumbar spine from baseline to 16 weeks. Secondary endpoints were changes in serum cross-linked N-telopeptides of type I collagen (sNTX) and bone alkaline phosphatase (sBAP), complications including hypocalcemia and osteonecrosis of the jaw, new bone fractures, changes in the Japanese Osteoporosis Quality of Life Questionnaire.
Results
Lumbar spine BMD significantly increased in 71.4% of cases: 2.772% (95% CI, 1.350–4.195%: P < 0.0001). There were also significant decreases in sNTX (P = 0.034) and sBAP levels (P < 0.001). Although one case (2.4%) of jaw osteonecrosis was diagnosed, no fractures occurred. In a cross-trial comparison with ESPRESSO-01, there was no significant difference in the incidence of National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) grade 3 or higher adverse events. However, inclusion of grade ≤2 showed significantly higher incidence of hypocalcemia with any CTCAE grade in ESPRESSO-02 (28.4% in ESPRESSO-01, 54.8% in ESPRESSO-02, P = 0.006)
Conclusion
Denosumab administration prevented secondary BMD reduction in GIC patients undergoing chemotherapy, and was associated with decreased serum levels of the bone turnover markers BAP and NTX.
Erosão diferencial e propriedades geomorfológicas das rochas – exemplos do NE Brasileiro
Authors: Maia Rubson Pinheiro 
Published: November 2021

Vários condicionantes litológicos e estruturais influenciam os processos de erosão diferencial do embasamento. No Nordeste Brasileiro é possível identificar muitos exemplos onde a erosão têm distinguido formas de relevo segundo seus controles lito-estruturais. Esses controles são representados principalmente pelo grau de faturamento, pela litologia/faciologia e pelos planos de foliação ígnea, metamórfica e de acamamento, nos terrenos sedimentares. O presente artigo fará uma análise de diferentes padrões de relevo que se desenvolvem em tipos litológicos distintos ou em uma mesma unidade litológica a partir da correlação de fácies. Nesse sentido, a manutenção de topografias elevadas no embasamento resulta da menor erosão em núcleos de resistência mecânica aos processos denudacionais. Essa resistência se deve sobretudo as características litológicas, faciológicas, petrográficas e estruturais que se somam para aumentar ou diminuir a coesão físico-química da rocha frente à meteorização.
Theranostic Applications of Nanomaterials in Alzheimer’s Disease: A Multifunctional Approach
Authors: Tripathi Priyanka , Shukla Poonam , Bieberich Erhard 
Published: November 2021

:
The blood-brain barrier (BBB) prevents the transfer of many therapeutic drugs across the brain.
Therefore, the leading treatment strategies of Alzheimer’s disease (AD) are often unsuccessful. Another challenge
is to achieve specific targetability across BBB and diagnosis. Herein, theranostic-based strategies are
emerging in order to combine therapeutic, targeting, and diagnostic capabilities. Recent nanotechnological advancements
enable a common platform for the formulation and development of efficient theranostics. This can
be attained by engineering some of the properties of nanomaterials, thus enabling them to become efficient and
suitable theranostics. In this review, we discuss the various novel approaches of theranostic nanomaterials owing
to multimodal functionality across the brain as an effective and probable treatment as well as early (timely)
diagnosis of Alzheimer’s disease. In this respect, we conducted a PubMed search to review the latest development
in theranostic nanomaterials, especially for Alzheimer’s (major type of dementia) therapy that led us to
discuss the present theranostic nanomaterials utilizing drug carriers that include cargo, targeting ligands, and
imaging agents for delivery to particular tissues, cells, or subcellular components. Our focus is on strategies for
syntheses, but we will also consider the challenges and prospects associated with this evolving technology. The
current review includes knowledge of the history, overview of AD, and therapeutics with a future approach of
using theranostic nanomaterials as personalized medicines.
Higher Teicoplanin Blood Level Needed in Elderly Critically Ill Patients
Authors: Wang Ling , Chen Mingguang , Ye Hong , Lin Xiaolan , Li Yixuan , Ruan Junshan , Lin Fenghui , Lin Yuxing 
Published: November 2021

Background:
Significant changes in the pathophysiology of older critically ill patients may affect the
pharmacokinetics and pharmacodynamics of teicoplanin. This study aimed to determine the optimal teicoplanin
blood level in this patient population.

Materials & Methods:
128 older critically ill and 86 older non-critically ill patients were involved and analyzed.

Results:
The target thresholds of teicoplanin blood concentrations in older critically ill patients and non-critically ill
patients should be 31.4mg/L and 15.3mg/L, respectively. The dose of teicoplanin in older critically ill patients should
be greater than 800 mg to achieve the target blood level.

Conclusion :
An individualized dosing approach of teicoplanin based on therapeutic drug monitoring is necessary for
older critically ill patients.
Oxidative Stress as a Molecular Mechanism of Exposure to Organophosphorus
Pesticides: A Review
Authors: Freyre Eva Ortega , Valencia Alfredo Tellez , Guzmán Dealmy Delgadillo , Maldonado Irais Castillo , Ledezma Laura Ernestina Barragán , Carrillo Maira Fernanda Zambrano , Escorza Martha Angelica Quintanar 
Published: November 2021

:
Exposure to organophosphorus pesticides is an important public health issue due to a
large number of occupationally exposed populations, as well as their effects mainly at the level of
the nervous, reproductive, and immune systems. It has been reported that one of the molecular
mechanisms by which adverse effects of exposure to organophosphorus pesticides can be explained
is oxidative stress, which leads to alterations at the cellular level that, if chronic, could affect
the functionality of different organs and tissues. These data constitute the basis of the relevant
literature on its toxicity. The induction of oxidative damage, which has been referred to, increases
the occurrence of processes such as eryptosis and/or hemolysis in erythrocytes that promote greater
susceptibility to clinical conditions such as anemia, dehydration, and chronic kidney disease. Thus,
it is mentioned that the determination of oxidative damage parameters could be useful to monitor
occupationally exposed people by exploring their oxidative status. This review focuses on presenting
the state of knowledge in recent years on the toxicity of organophosphorus pesticides and their
relationship with the oxidative damage evaluated in erythrocytes.
Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and
Hybrids of Benzofurans with other Pharmacophores as Antibacterial
Agents
Authors: Xu Zhi , Xu Dan , Zhou Wei , Zhang Xiaoyan 
Published: November 2021

Abstract:
Gram-positive and Gram-negative pathogens are able to evade the host immune system, persist within the human host, and lead to severe disease and even death. At present, bacterial infec-tions are one of the leading causes of morbidity and mortality across the world. The development of novel antibacterial agents still represents a challenging endeavor, which is mainly attributed to the continuous emergence of more virulent and drug-resistant pathogens. Benzofuran constitutes the core of diverse pharmacologically active compounds, and there are a variety of approved benzofuran-based drugs in the market or currently going through different clinical phases or registration statuses. Benzofurans could exert antibacterial activity through various mechanisms and possess pronounced activity; therefore, benzofuran is a useful skeleton for the discovery of novel antibacterial agents. This review focuses on the recent advancement of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents, covering articles published be-tween January 2015 and July 2021. The chemical structures and structure-activity relationships are also discussed.
Taurine: A Water Friendly Organocatalyst in Organic Reactions
Authors: Agarwal Shikha , Kalal Priyanka , Sethiya Ayushi , Soni Jay 
Published: November 2021

:Organocatalysis has become a powerful tool in organic synthesis for the formation of C-C and C-X (N, S, O, etc.) bonds, leading to the formation of complex molecules from easily available starting materials. It provides an alternative platform to the conventional synthesis and fulfills the principles of green chemistry. During the last decades, taurine has emerged as a promising organocatalyst in an array of organic transformations in addition to its plentiful biological properties. It is highly stable, easy to store and separate, water-soluble, of low cost, easily available, and recyclable. The present article highlights the recent and up-to-date applications of taurine in organic transformations.
Comparison Between Kidney and Liver Transplant Recipients Admitted
to a Referral Center Regarding Coronavirus-2019 Manifestations in the
Northeast of Iran During Three Peaks of Pandemic
Authors: Aliakbarian Mohsen , Khodashahi Rozita , Sabbagh Mahin Ghorban , Naderi Hamid Reza , Khodashahi Mandana , Jahanian Shahrzad , Moghaddam Maliheh Dadgar 
Published: November 2021

Background:
Transplant recipients are at high risk for severe Coronavirus disease-2019
(COVID-19). Transplant recipients are immune-compromised individuals at high risk for severe infection.
This study aimed to compare the presentations and outcomes of liver and kidney transplant
recipients who were infected with COVID-19 in the Iranian population.

Methods:
This cross-sectional study was conducted at Imam Reza and Montaserieh Hospitals affiliated
with Mashhad University of Medical Sciences, Mashhad, Iran, between 2020 and 2021. In general,
52 patients were selected and divided into two groups of the kidney (n=28) and liver (n=24)
transplantation. Two groups were compared in terms of demographic characteristics and clinical
findings.

Results:
Of the 52 patients, severe COVID-19 infection was reported in 61% of the patients. There
was no significant difference between the two groups in terms of symptoms, except for cough
(χ2=8.09; P=0.004), clinical condition, and laboratory symptoms, except for creatinine (Z=14;
P<0.005), alkaline phosphatase (Z=4.55; P=0.03), total bilirubin (Z=8.93; P=0.03), and partial
thromboplastin time (Z=5.97; P=0.01). There was no relationship between the outcome and the use
of immunosuppressive medications (P>0.05). All patients with kidney transplantation survived,
while two cases in the liver transplantation group failed to survive (χ2=2.42; P=0.11).

Conclusion:
The mortality rate was higher in the liver transplant recipients, compared to the patients
who underwent kidney transplantation.
CRITICIZING THE BUGIS ISLAMIC SCRIPT, PAU-PAU RIKADONNA I DARAMATASIA FROM SIRIQ NA PESSÉ PERSPECTIVE
Authors: Bermawy Munthe  , Mustari Mustari , Maharsi  
Published: November 2021

Pau-Pau Rikadonna I Daramatasia (PRID) is a very popular story and has an important position in the lives of Bugis people in South Sulawesi as well as in other region. In the script form, the story has three versions: Bone, Barru, and Pangkep. Not only being written in script form, the story is also staged in short films, picture stories, dances, and others. This article aims to understand the meaning for the Bugis' collective awareness of PRID stories. To reveal the meaning, Bone version of PRID will be used with considering the whole story. Bone's PRID is also unique because it has some additions of episodes at the beginning and at the end of the story that become the focus of this article analysis. In understanding the meaning contained in the PRID, Levi Strauss's theory of structuralism will be used by building binary opposition to the depth structure of the text. Based on the analysis conducted, the addition of episodes contained in the PRID version of Bone is closely related to the cultural value ofÂ siriq na pesseÂ (honor and solidarity) which is opposing sharia values. This can be interpreted as an effort by the Bugis to reconcile the two values so that PRID is well thanked and appreciated until now as can be seen in Youtube contents.
Performance and Sustainability of Halal Food Smes
Authors: Qurniawati Rina Sari , Nurohman Yulfan Arif 
Published: November 2021

This study investigates the performance and sustainability of halal food SMEs in the FinTech era. The large aggregate contribution of SMEs does not yet reflect good performance in domestic and foreign market competition due to lack of financial literacy. FinTech can support financial literacy so performance and sustainability SMEs will increase. Consequently, testing the effect of fintech and literacy on the performance and sustainability of MSMEs. A total of one hundred respondents are selected using the quantitative method as sources of data collection. The questionnaires are distributed using a purposive sampling method in Surakarta, Indonesia. The software used for analysis is SEM-PLS. Â The results of this study state that the performance and sustainability of SMEs are influenced by FinTech and financial literacy
Factors Associated With Nonattendance in a Nationwide Screening Program for Diabetic Retinopathy: A Register-Based Cohort Study
Authors: Petersen Gabriela B. , Byberg Stine , Vistisen Dorte , Fangel Mia V. , Vorum Henrik , Joensen Lene E. , Kristensen Jette K. 
Published: November 2021

OBJECTIVEThe aim of the study was to identify factors associated with nonattendance in a Danish nationwide screening program for diabetic retinopathy among people with type 2 diabetes.RESEARCH DESIGN AND METHODSA retrospective observational study linking individual-level register data was performed. First, we compared characteristics of 156,878 people with type 2 diabetes divided into attenders and never-attenders on the basis of their screening history over a 6-year period. Second, we assessed 230,173 screening intervals within the same 6-year period. Mixed-effects models were used to investigate the effect of sociodemographic and health-related factors on the likelihood of having a nonattender interval (i.e., failing to attend screening within the recommended interval).RESULTSA total of 42,068 (26.8%) people were identified as never-attenders, having no registered eye screening over a 6-year period. Compared with attenders, never-attenders were more frequently divorced/widowed, lived in the Capital Region of Denmark, and had poorer health. A total of 62,381 (27.1%) screening intervals were identified as nonattender intervals. Both sociodemographic and health-related factors were significantly associated with the likelihood of having a nonattender interval. The largest odds ratios for nonattendance were seen for mental illness, nonwestern descent, divorce, comorbidity, and place of residence.CONCLUSIONSOur findings suggest that never- and nonattendance of screening for diabetic retinopathy are more common among people who are divorced/widowed and of poorer health. Additionally, nonattendance is more frequent among people of nonwestern decent. These population subgroups may benefit from targeted interventions aimed at increasing participation in diabetic retinopathy screening.
«Det snakker vi ikke om! Familiehemmeligheter etter krigen»: Et blikk på krigens langtidskonsekvenser i et tre-generasjoners perspektiv
Authors: Pabst Kathrin 
Published: November 2021

Under the surface of our societies, there are thousands and thousands of stories which could add nuances and details to a black-and-white picture of historical events. But many of these stories are too private, too personal or too traumatic to share. Feelings like despair, shame or guilt might be associated, and one could be afraid of the reactions of others when telling them. Here, museum institutions and museum professionals might function as mediators and connecting links between those who want to share but do not know how – and those who need to know.
In this article, we present the first results of a documentary- and exhibition project dealing with the long-term consequences of WW2—in the families and in the local societies. 21 informants, mainly from the second and third generation, were questioned about how difficult and traumatic experiences—during or after the war—affected their families and their own feeling of identity. The answers we received showed that especially the not-knowing what has happened often has severe effects on one’s personal life and well-being.
IMPLEMENTASI MUSHÄ€RAKAH MUTANÄ€QIÅžAH WAL IJÄ€RAH DALAM PEMBIAYAAN HUNIAN SYARIAH PADA PT. BANK MUAMALAT INDONESIA CABANG PONOROGO
Authors: Sarpini Sarpini 
Published: November 2021

The price of a house that is increasingly expensive makes not everyone can afford it because home is one of the basic needs for everyone. Bank Muamalat Indonesia has a financing product for the home namely is financing musyÄrakah mutanÄqiÅŸah wal ijÄrah.
This research is both a descriptive analysis, i.e. the author lays out all the data that includes data about the reasons to use the musyÄrakah mutanÄqiÅŸah wal ijÄrah in financing Residential Sharia in PT.Bank Muamalat Indonesia Branch Ponorogo. contract relationships and data on musyÄrakah mutanÄqiÅŸah and ijÄrah in financing Residential Sharia in PT.Bank Muamalat Indonesia Branch systematically Ponorogo, meticulous and factual with the deductive pattern i.e. a fringe theories or propositions that are common on musyÄrakah mutanÄqiÅŸah then do an analysis of the data concerning multi contract to acquire a specific conclusion.This research concluded that the reason Bank Muamalat Indonesia branch using contract Ponorogo musyÄrakah mutanÄqiÅŸah wal ijÄrah in financing the residence of Islamic Muamalat (PHSM) namely musyÄrakah mutanÄqiÅŸah wal ijÄrah is suitable for contract be used as an alternative solution in financing PHSM in Bank Muamalat Indonesia branch Ponorogo.Bank Muamalat Indonesia branch using contract Ponorogo musyÄrakah mutanÄqiÅŸah wal ijÄrah in financing the residence of Islamic Muamalat (PHSM) is reviewed from a multiple of contract that is allowed under Islamic law and does not include the category of the prohibition Hadith.The relationship contract musyÄrakah mutanÄqiÅŸah and ijÄrah in Islamic Muamalat Residential Financing (PHSM) in Bank Muamalat Indonesia branch Ponorogo i.e. Shirkat al-' Belong ' (shared ownership) and ijÄrah.
Brand Awareness, Brand Image Dan Brand Loyalty Sebagai Prediktor Brand Equity Adidas
Authors: Agnes Novia , Darmawan Happy 
Published: November 2021

The purpose of this study to examine whether brand awareness, brand image and brand loyalty can predict brand equity Adidas in Jakarta. The population in this study were Adidas consumers in Jakrata. The sample was 100 respondents with a convenience sampling technique questionnarise ans using SmartPLS 3 software. Overall, the result of this research were brand awareness positive and significant as a predictor of brand equity, brand image positive and significant as a predictor of brand equity, and brand loyalty positive and significant as a predictor of brand equity. Tujuan dari penelitian ini adalah untuk menguji apakah brand awareness, brand image dan brand loyalty dapat memprediksi brand equity Adidas di Jakarta. Populasi dalam penelitian ini adalah konsumen Adidas di Jakarta. Sampel adalah 100 responden dengan kuesioner teknik convenience sampling dan menggunakan perangkat lunak SmartPLS 3. Secara keseluruhan, hasil dari penelitian ini brand awareness secara positif dan signifikan menjadi prediktor brand equity, brand image secara positif dan signifikan menjadi prediktor brand equity, brand loyalty secara positif dan signifikan menjadi prediktor brand equity Adidas.
Perspective on the true incidence of bowel perforations occurring with extreme lateral lumbar interbody fusions. How should they be treated?
Authors: Epstein Nancy E. 
Published: November 2021

Background:
What is the risk of bowel perforation (BP) with open or minimally invasive (MI) extreme lateral lumbar interbody fusion (XLIF)? What is the truth? Further, if peritoneal symptoms/signs arise following XLIF/MI XLIF, it is critical to obtain an emergent consultation with general surgery who can diagnose and treat a potential BP.

Literature Review:
In multiple series, the frequency of BP ranged markedly from 0.03% (i.e. 1 of 2998 patients), to 0.08% (11/13,004), to 0.5%, to 8.3% (1 in 12 patients), up to 12.5% (1 in 8 patients). BPs attributed to different causes carry high mortality rates varying from 11.1% to 23%. For the 11 (0.08%) BP occurring out of 13,004 patients undergoing XLIF in one series, there was one (9.09%) death due to uncontrolled sepsis. In another series, where 31 BP were identified for multiple lumbar surgical procedures identified through PubMed (1960–2016), including 10 (32.2%) for lateral lumbar surgery including XLIF, the overall mortality rate was 12.9% (4/31).

Conclusion:
The incidence of BPs occurring following XLIF/MI XLIF procedures ranged from 0.03% to 12.5% in various reports. What is the true incidence of these errors? Certainly, it is more critical that when spine surgeons’ patients develop acute peritoneal symptoms/signs following these procedures, they immediately consult general surgery to both diagnose, and treat potential BP in a timely fashion to avoid the high morbidity (87.1%) and mortality rates (12.9%) attributed to these perforations.
The Benefits of Fine Art Integration into Mathematics in Primary School
Authors: Brezovnik Anja 
Published: November 2021

The main purpose of the article is to research the effects of the integration of fine art content into mathematics on students at the primary school level. The theoretical part consists of the definition of arts integration into education, a discussion of the developmental process of creative mathematical thinking, an explanation of the position of art and mathematics in education today, and a summary of the benefits of arts integration and its positive effects on students. The empirical part reports on the findings of a pedagogical experiment involving two different ways of teaching fifth-grade students: the control group was taught mathematics in a traditional way, while the experimental group was taught with the integration of fine art content into the mathematics lessons. At the end of the teaching periods, four mathematics tests were administered in order to determine the difference in knowledge between the control group and the experimental group. The results of our study confirmed the hypotheses, as we found positive effects of fine art integration into mathematics, with the experimental group achieving higher marks in the mathematics tests than the control group. Our results are consistent with the findings of previous research and studies, which have demonstrated and confirmed that long-term participation in fine art activities offers advantages related to mathematical reasoning, such as intrinsic motivation, visual imagination and reflection on howto generate creative ideas.