bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicians’ perspectives on continuity of care for patients involved in the criminal justice system: A qualitative study
Authors: Jennings Latasha , Branson Carolina Fernández , Maxwell Andrea M. , Winkelman Tyler N. A. , Shlafer Rebecca J. 
Published: July 2021

BackgroundIn 2016, over 11 million individuals were admitted to prisons and jails in the United States. Because the majority of these individuals will return to the community, addressing their health needs requires coordination between community and correctional health care providers. However, few systems exist to facilitate this process and little is known about how physicians perceive and manage these transitions.ObjectiveThe goal of this study was to characterize physicians’ views on transitions both into and out of incarceration and describe how knowledge of a patient’s criminal justice involvement impacts patient care plans.MethodsSemi-structured interviews were conducted between October 2018 and May 2019 with physicians from three community clinics in Hennepin County, Minnesota. Team members used a hybrid approach of deductive and inductive coding, in which a priori codes were defined based on the interview guide while also allowing for data-driven codes to emerge.ResultsFour themes emerged related to physicians’ perceptions on continuity of care for patients with criminal justice involvement. Physicians identified disruptions in patient-physician relationships, barriers to accessing prescription medications, disruptions in insurance coverage, and problems with sharing medical records, as factors contributing to discontinuity of care for patients entering and exiting incarceration. These factors impacted patients differently depending on the direction of the transition.ConclusionsOur findings identified four disruptions to continuity of care that physicians viewed as key barriers to successful transitions into and out of incarceration. These disruptions are unlikely to be effectively addressed at the provider level and will require system-level changes, which Medicaid and managed care organizations could play a leading role in developing.
Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-controlled trial
Authors: Khoo Joan , Hagemeyer Christoph E. , Henstridge Darren C. , Kumble Sumukh , Wang Ting-Yi , Xu Rong , Gani Linsey , King Thomas , Soh Shui-Boon , Puar Troy , Au Vanessa , Tan Eberta , Tay Tunn-Lin , Kam Carmen , Teo Eng-Kiong 
Published: July 2021

Background
Diabetes mellitus is associated with inadequate delivery of oxygen to tissues. Cellular hypoxia is associated with mitochondrial dysfunction which increases oxidative stress and hyperglycaemia. Hyperbaric oxygenation therapy, which was shown to improve insulin sensitivity, is impractical for regular use. We evaluated the effects of water which is stably-enriched with oxygen (ELO water) to increase arterial blood oxygen levels, on mitochondrial function in the presence of normal- or high-glucose environments, and as glucose-lowering therapy in humans.

Methods
We compared arterial blood oxygen levels in Sprague-Dawley rats after 7 days of ad libitum ELO or tap water consumption. Mitochondrial stress testing, and flow cytometry analysis of mitochondrial mass and membrane potential, were performed on human HepG2 cells cultured in four Dulbecco’s Modified Eagle Medium media, made with ELO water or regular (control) water, at normal (5.5 mM) or high (25 mM) glucose concentrations. We also randomized 150 adults with type 2 diabetes (mean age 53 years, glycated haemoglobin HbA1c 8.9% [74 mmol/mol], average duration of diabetes 12 years) to drink 1.5 litres daily of bottled ELO water or drinking water.

Results
ELO water raised arterial oxygen tension pO2 significantly (335 ± 26 vs. 188 ± 18 mmHg, p = 0.006) compared with tap water. In cells cultured in control water, mitochondrial mass and membrane potential were both significantly lower at 25 mM glucose compared with 5.5 mM glucose; in contrast, mitochondrial mass and membrane potential did not differ significantly at normal or high glucose concentrations in cells cultured in ELO water. The high-glucose environment induced a greater mitochondrial proton leak in cells cultured in ELO water compared to cells cultured in control medium at similar glucose concentration. In type 2 diabetic adults, HbA1c decreased significantly (p = 0.002) by 0.3 ± 0.7% (4 ± 8 mmol/mol), with ELO water after 12 weeks of treatment but was unchanged with placebo.

Conclusions
ELO water raises arterial blood oxygen levels, appears to have a protective effect on hyperglycaemia-induced reduction in mitochondrial mass and mitochondrial dysfunction, and may be effective adjuvant therapy for type 2 diabetes.
Impact of insurance type on outcomes in cardiac arrest patients from 2004 to 2015: A nation-wide population-based study
Authors: Lee Si Jin , Han Kap Su , Lee Eui Jung , Lee Sung Woo , Ki Myung , Ahn Hyeong Sik , Kim Su Jin 
Published: July 2021

Objectives
There do not appear to be many studies which have examined the socio-economic burden and medical factors influencing the mortality and hospital costs incurred by patients with cardiac arrest in South Korea. We analyzed the differences in characteristics, medical factors, mortality, and costs between patients with national health insurance and those on a medical aid program.

Methods
We selected patients (≥20 years old) who experienced their first episode of cardiac arrest from 2004 to 2015 using data from the National Health Insurance Service database. We analyzed demographic characteristics, insurance type, urbanization of residential area, comorbidities, treatments, hospital costs, and mortality within 30 days and one year for each group. A multiple regression analysis was used to identify an association between insurance type and outcomes.

Results
Among the 487,442 patients with cardiac arrest, the medical aid group (13.3% of the total) had a higher proportion of females, rural residents, and patients treated in low-level hospitals. The patients in the medical aid group also reported a higher rate of non-shockable conditions; a high Charlson Comorbidity Index; and pre-existing comorbidities, such as hypertension, diabetes mellitus, and renal failure with a lower rate of providing a coronary angiography. The national health insurance group reported a lower one-year mortality rate (91.2%), compared to the medical aid group (94%), and a negative association with one-year mortality (Adjusted OR 0.74, 95% CI 0.71–0.76). While there was no significant difference in short-term costs between the two groups, the medical aid group reported lower long-term costs, despite a higher rate of readmission.

Conclusions
Medical aid coverage was an associated factor for one-year mortality, and may be the result of an insufficient delivery of long-term services as reflected by the lower long-term costs and higher readmission rates. There were differences of characteristics, comorbidities, medical and hospital factors and treatments in two groups. These differences in medical and hospital factors may display discrepancies by type of insurance in the delivery of services, especially in chronic healthcare services.
Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study
Authors: Wang Sheng-Min , Han Kyung-do , Kim Nak-Young , Um Yoo Hyun , Kang Dong-Woo , Na Hae-Ran , Lee Chang-Uk , Lim Hyun Kook 
Published: July 2021

Objective
Late-life depression and subjective cognitive decline (SCD) are significant risk factors for dementia. However, studies with a large sample size are needed to clarify their independent and combined risks for subsequent dementia.

Methods
This nationwide population-based cohort study included all individuals aged 66 years who participated in the National Screening Program between 2009 and 2013 (N = 939,099). Subjects were followed from the day they underwent screening to the diagnosis of dementia, death, or the last follow-up day (December 31, 2017).

Results
Depressive symptom presentation, recent depressive disorder, and SCD independently increased dementia incidence with adjusted hazard ratio (aHR) of 1.286 (95% CI:1.255–1.318), 1.697 (95% CI:1.621–1.776), and 1.748 (95% CI: 689–1.808) respectively. Subjects having both SCD and depression had a higher risk (aHR = 2.466, 95% CI:2.383–2.551) of dementia than having depression (aHR = 1.402, 95% CI:1.364–1.441) or SCD (aHR = 1.748, 95% CI:1.689–1.808) alone.

Conclusions
Depressive symptoms, depressive disorder, and SCD are independent risk factors for dementia. Co-occurring depression and SCD have an additive effect on the risk of dementia; thus, early intervention and close follow up are necessary for patients with co-occurring SCD and depression.
Risk factors for severe neutropenia in pancreatic cancer patients treated with gemcitabine/nab-paclitaxel combination therapy
Authors: Ito Genta , Kawakami Kazuyoshi , Aoyama Takeshi , Yokokawa Takashi , Nakamura Masashi , Ozaka Masato , Sasahira Naoki , Hashiguchi Masayuki , Kizaki Hayato , Hama Toshihiro , Hori Satoko 
Published: July 2021

Aim
Combination therapy with gemcitabine and nanoparticle albumin-bound paclitaxel (nab-paclitaxel), known as GnP therapy, significantly prolongs the survival of pancreatic cancer patients compared with gemcitabine monotherapy. However, it may cause severe neutropenia, requiring discontinuation of treatment. This study aimed to clarify the risk factors for Grade 3/4 neutropenia during GnP therapy.

Methods
Clinical data of pancreatic cancer patients who underwent GnP therapy at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research from December 2014 to December 2016 were retrospectively collected. The relationship of Grade 3/4 neutropenia onset to laboratory values and patient background factors was investigated by multivariate logistic regression analysis.

Results
Clinical data of 222 patients were analyzed. Grade 3/4 neutropenia occurred in 118 patients (53.2%) in the first cycle of GnP therapy. Multivariate analysis identified low absolute neutrophil count (ANC), high total bilirubin (T-Bil), and low C-reactive protein (CRP) as risk factors for Grade 3/4 neutropenia. Age was not a risk factor. The incidence of neutropenia was 85.7% in patients with all three risk factors, but only 27.7% in patients with none of them.

Conclusion
Low ANC, high T-Bil, and low CRP may be risk factors for Grade 3/4 neutropenia in patients receiving GnP therapy, even if these laboratory values are within normal reference ranges. Patients with these risk factors should be carefully monitored for adverse events.
‘Communal Hellenism’ and ancient tragedy performances in Greece (1975–95): The ritual quest
Authors: Kaltsounas Efthymios , Karaoglou Tonia , Minioti Natalie , Papazoglou Eleni 
Published: July 2021

For the better part of the twentieth century, the quest for a ‘Greek’ continuity in the so-called revival of ancient drama in Greece was inextricably linked to what is termed and studied in this paper as a Ritual Quest. Rituality was understood in two forms: one was aesthetic and neoclassicist in its hermeneutic and performative codes, which were established and recycled – and as such: ritualized – in ancient tragedy productions of the National Theatre of Greece from the 1930s to the 1970s; the other, cultivated mainly during the 1980s, was cultural and centred around the idea that continuity can be traced and explored through the direct employment of Byzantine and folk ritual elements. Both aimed at eliciting the cohesive collective response of their spectators: their turning into a liminal ritual community. This was a community tied together under an ethnocentric identity, that of Greeks participating in a Greek (theatrical) phenomenon. At first through neoclassicism, then through folklore, this artistic phenomenon was seen as documenting a diachronic and essentially political modern Greek desideratum: continuity with the ancient past.
Such developments were in tune with broader cultural movements in the period under study, which were reflected on the common imaginings of Antiquity in the modern Greek collective – consciousness – a sort of ‘Communal Hellenism’. The press reception of performances, apart from being a productive vehicle for the study of the productions as such, provides indispensable indexes to audience reception. Through the study of theatre reviews, we propose to explore the crucial shifts registered in the definition of Greekness and its dynamic connections to Antiquity.
Kondisi Padang Lamun di Perairan Teluk Awur Jepara Terkait dengan Parameter Lingkungan Perairan dan Keberadaan Sampah Makro Plastik
Authors: Kurniawan Hendra , Yulianto Bambang , Riniatsih Ita 
Published: July 2021

Ekosistem padang lamun merupakan salah satu ekosistem di wilayah pesisir yang mempunyai peranan yang penting untuk menjaga kelestarian dan keanekaragaman organisme laut. Kondisi parameter perairan pesisir merupakan faktor penting terhadap kondisi padang lamun yang meliputi kecerahan perairan, pasang surut, arus, gelombang, suhu, salinitas, DO, kadar BOT dan pencemaran. Penelitian ini bertujuan untuk melihat pengaruh kondisi oseanografi dan sampah makro plastik terhadap kondisi padang lamun di perairan Teluk Awur Jepara yang dilakukan pada 3 stasiun pengamatan. Hasil penelitian menunjukkan bahwa bahwa tipe pasang surut di lokasi pengamatan adalah mixed tide prevailing semi durnal. Kisaran data kecerahan 30-40 cm, kisaran kecepatan arus antara 0,109-0,0154 m/det, tinggi gelombang 0,5-126 cm, suhu 28-30 0c, salinitas 34-35%, kisaran kadar DO 4,2-4,9 ppm, dan kisaran kadar BOT 9,9-11,9 mg/liter. Kisaran berat sampah yang di temukan 0,08 kg- 1,8 kg di seluruh stasiun. Kisaran prosentase penutupan lamun seluruh stasiun 14,678% - 20,706%, hal ini menunjukan bahwa kondisi padang lamun di perairan Teluk Awur dalam kondisi tidak sehat (>25%). Seagrass ecosystem is one of the ecosystems in coastal areas that has an important role to maintain the sustainability and diversity of marine organisms. The condition of coastal water parameters is an important factor for seagrass conditions including waters brightness, tides, currents, waves, temperature, salinity, DO, BOT levels and pollution. This study aims to look at the effect of oceanographic conditions and macro plastic waste on seagrass conditions in the waters of Teluk Awur Jepara conducted at 3 observation stations. The results showed that the tidal type at the observation site was mixed tide prevailing semi durnal. Brightness data range is 30-40 cm, current speed range is between 0.109-0.0154 m / sec, wave height is 0.5-126 cm, temperature is 28-30 0c, salinity is 34-35%, DO content range is 44,2-4,9ppm, and the range of BOT levels 9.9-11.9 mg / liter. The range of waste weight found was 0.08 kg - 1.8 kg at all stations. The range of seagrass closure percentage for all stations is 14.678% - 20.706%, this shows that the condition of seagrass in waters of Teluk Awur Jepara is in an unhealthy condition (>25%).
Sebaran Konsentrasi Material Padatan Tersuspensi dan Fosfat di Perairan Semarang, Jawa Tengah
Authors: Utama I Made Rifaldy Puja , Maslukah Lilik , Wulandari Sri Yulina 
Published: July 2021

Sungai Banjir Kanal Barat dan Banjir Kanal Timur merupakan sungai besar yang berperan dalam mempengaruhi nilai kualitas perairan Semarang. Sungai ini membawa material dan limbah yang berasal dari darat kemudian mengalir ke laut melalui muara sungai. Penelitian ini bertujuan untuk mengetahui nilai konsentrasi zat padat tersuspensi (MPT) dan fosfat serta pola distribusinya. Penelitian ini dilaksanakan pada bulan Februari 2019 dengan menggunakan metode deskriptif kuantitatif. Metode penentuan lokasi menggunakan purposive sampling pada 22 stasiun yang dapat merepresentasikan wilayah muara dan laut. Penentuan MPT secara gravimetri dan fosfat menggunakan metode asam askorbat. Hasil konsentrasi MPT berkisar antara 50-290 mg/L dan fosfat 0,95-0,16 mg/L. Pola distribusi secara horisontal MPT menunjukkan lebih tinggi di daerah dekat pantai dan pola sebaran vertikal menunjukkan lebih tinggi di permukaan (0,2 m) dibanding di bagian bawah (0,8 m). Pola sebaliknya ditemukan pada sebaran fosfat dengan nilai lebih tinggi di dasar dan pola sebaran spasialnya menunjukkan konsentrasi tinggi ditemukan di wilayah timur yaitu di Muara Sungai Banjir Kanal Timur. Sungai Banjir Kanal Timur memberikan kontribusi yang besar terhadap unsur hara fosfat terlarut. The Banjir Kanal Barat and Banjir Kanal Timur River are major rivers that play a role in influencing the quality value of Semarang waters. This river carries material and waste originating from the land and then flows out to the sea through the river mouth. This study aims to determine the concentration value of suspended solids (MPT) and phosphate and the distribution pattern. This research was conducted in February 2019, using descriptive quantitative methods. The method of determining the location uses purposive sampling at 22 stations that can represent the estuary and sea areas. Gravimetric and phosphate determination of MPT using the ascorbic acid method. The results of MPT concentrations ranged from 50-290 mg / L and phosphate from 0.95 to 0.16 mg/L. Spatial distribution of MPT shows a high concentration in the coastal area and vertically, the distribution is higher at the surface (0.2 m) than at the bottom (0.8 m). This pattern is different from the phosphate which is found to be higher at the bottom with its spatial distribution showing a high concentration in the eastern region, namely in the estuary of Banjir Kanal Timur. This estuary of Banjir Kanal Timur has a large contribution to phosphate ions.
Hubungan Kandungan Nitrat Dan Fosfat Dalam Substrat Terhadap Kerapatan Lamun Di Perairan Pantai Prawean, Jepara
Authors: Subiakto Achmad Yusuf , Santosa Gunawan Widi , Suryono Suryono , Riniatsih Ita 
Published: July 2021

Senyawa nitrat dan fosfat merupakan nutrien yang dapat dijadikan sebagai petunjuk kesuburan perairan dan dibutuhkan baik pertumbuhan dan perkembangan lamun. Nutrien di perairan padang lamun berperan sebagai faktor pembatas pertumbuhan. Penyerapan nutrien oleh lamun dilakukan oleh daun dan akar. Besarnya kandungan nutrien dalam sedimen bukan berarti akan selalu dalam konsentrasi yang sama pada karakteristik sedimen dasar dan kedalaman perairan. Bila terjadi perbedaan maka hal ini bisa mempengaruhi terjadinya perbedaan kondisi kepadatan dan sebaran pada setiap jenis lamun yang tumbuh dalam perairan, oleh karena itu perlu dilakukan penelitian tentang hubungan kandungan Nitrat dan fosfat dalam substrat terhadap kerapatan lamun di perairan pantai Prawean, Jepara. Penelitian ini dilakukan pada bulan Desember 2018- Januari 2019. Metode penentuan lokasi pengambilan sampel dengan metode purposive sampling. Materi yang digunakan dalam penelitian adalah sampel sedimen, parameter perairan, dan kerapatan lamun. Berdasarkan hasil penelitian didapatkan Nilai kandungan Nitrat di substrat Perairan Pantai Prawean Jepara berkisar antara 1,27–1,36 mg/L tergolong pada kategori kesuburan rendah. Nilai kandungan Fosfat pada sedimen yaitu 0,049–0,086 mg/L tergolong pada kategori rendah hingga tinggi. Tingkat kerapatan padang lamun berada pada kondisi kerapatan sangat rapat (> 175 tegakan/m2). Nitrate and phosphate compounds are nutrients that could be used as an indicator of aquatic fertility and needed by for growth and development of seagrass. Nutrients in seagrass waters serve as a limiting factor for growth. Nutrient absorption by seagrass were done by leaves and roots. The amount of nutrient content in sediment does not mean would be always same at the concentration on the basic sediment characteristics and depth water level. If there is a difference, it will cause an affect the different conditions of density and distribution in each type of seagrass which grows in the waters, therefore it is necessary to do research about relation of nutrient in the substrate to seagrass density in Prawean Beach, Jepara. This research was conducted in December 2018 - January 2019. The method used in this study was descriptive method. The material used in the study were sediment samples, water parameters, and seagrass density. Based on the results , it was found that the value of nitrate in substrate in the waters of Prawean Jepara Beach ranged from 1.27 - 1.36 mg. L-1 belonging to the low fertility category. The value of Phosphate content in substrate was 0.049 - 0.086 mg. L-1 belonging to the low until high category. The density level of seagrass at the tight density condition very tight >175 stands. m-2.
Kelimpahan Rumput Laut Di Komunitas Lamun Di Perairan Pulau Nyamuk Kepulauan Karimunjawa
Authors: Putra Rio Adista Widodo , Santoso Adi , Riniatsih Ita 
Published: July 2021

Pulau Nyamuk merupakan salah satu pulau yang berada di bagian barat kepulauan Karimunjawa. Rumput laut dan lamun masuk dalam vegetasi pesisir yang ada di Pulau Karimunjawa. Tingginya aktivitas penangkapan ikan oleh nelayan dan rencana pembangunan sarana pariwisata diduga menjadi pemicu tertekannya 2 vegetasi laut tersebut di Pulau Nyamuk. Tujuan dilakukannya penelitian ini adalah mengidentifikasi jenis dan struktur komunitas rumput laut di padang lamun di perairan Pulau Nyamuk Kepulauan Karimunjawa. Materi yang digunakan dalam penelitian ini adalah tumbuhan rumput laut dan lamun. Penelitian ini menggunakan metode deskriptif eksplorasif. Penelitian ini dilakukan pada 3 stasiun yang berbeda di perairan Pulau Nyamuk, yaitu pada stasiun A bagian timur, stasiun B pada bagian barat dan stasiun C pada bagian utara Pulau Nyamuk. Ditemukan 5 jenis rumput laut jenis Padina australis, Halimeda macroloba, Caulerpa sertulairoides, Caulerpa racemosa dan Sargassum sp. dan 2 spesies lamun jenis Enhalus acoroides dan Halophila ovalis. Rata-rata total tutupan rumput laut adalah 48,61 % sedangkan tutupan lamun adalah 19,94 %. Nilai indeks keanekaragaman dan keseragaman rumput laut termasuk kategori rendah, kecuali pada perairan utara pulau nilai keanekaragamannya sedang dan nilai keseragamannya tinggi. Sedangkan indeks dominasi terlihat ada spesies rumput laut yang mendominasi pada perairan bagian barat dan timur pulau. Nyamuk Island is one of an island located in the western part of Karimunjawa archipelago. Seaweed and seagraas is a marine vegetation in Nyamuk Island. The highest fishing activities and the development plan of tourism facilities trigger the depressed ecological function these marine vegetation on Nyamuk Island. This study aims to identify the type and structure of the seaweed community in seagrass beds and the environmental factors of aquatic physics that affect the existence of seaweed and seagrass in the waters of Nyamuk Island. This research was conducted on August 29 to September 1, 2017, located at Nyamuk Island, District Karimunjawa, Jepara regency, Central Java Province. The material used in this research was seaweed and seagrass plants. This research parameter data taken directly (in situ). This research uses descriptive exploration method. This research was conducted on 3 different stations in the waters of Nyamuk Island, which is on the east, west and north of Nyamuk Island.Found 5 types of seaweed type Padina australis, Halimeda macroloba, Caulerpa sertulairoides, Caulerpa racemosa and Sargassum sp. and 2 species of seagrass species Enhalus acoroides and Halophila ovalis. The average total seaweed cover is 48.61% while the seagrass cover is 19.94%. The index value of diversity and uniformity of seaweed is low except in Northern Island, diversity value including medium and uniformity is high, while dominance index is seen that seaweed species dominate on Western and Eastern Island.