bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deforestation and climate change are projected to increase heat stress risk in the Brazilian Amazon
Authors: Alves de Oliveira Beatriz Fátima , Bottino Marcus J. , Nobre Paulo , Nobre Carlos A. 
Published: October 2021

AbstractLand use change and deforestation can influence local temperature and climate. Here we use a coupled ocean-atmosphere model to assess the impact of savannization of the Amazon Basin on the wet-bulb globe temperature heat stress index under two climate change scenarios (RCP4.5 and RCP8.5). We find that heat stress exposure due to deforestation was comparable to the effect of climate change under RCP8.5. Our findings suggest that heat stress index could exceed the human adaptation limit by 2100 under the combined effects of Amazon savannization and climate change. Moreover, we find that risk of heat stress exposure was highest in Northern Brazil and among the most socially vulnerable. We suggest that by 2100, savannization of the Amazon will lead to more than 11 million people will be exposed heat stress that poses an extreme risk to human health under a high emission scenario.
Quantitative phosphoproteomics reveals GSK3A substrate network is involved in the cryodamage of sperm motility
Authors: Wang Jing , Wang Jing , Wang Min , Hong Renyun , Tang Shanshan , Xu Yuanhua , Zhao Xia , Zhou Tao , Wang Zibin , Huang Shaoping 
Published: October 2021

Abstract
During sperm cryopreservation, the most significant phenotype of cryodamage is the decrease in sperm motility. Several proteomics studies have already been performed to search for key regulators at the protein level. However, sperm functions are known to be highly regulated by phosphorylation signaling. Here, we constructed a quantitative phosphoproteome to investigate the expression change of phosphorylated sites during sperm cryopreservation. A total of 3107 phosphorylated sites are identified and 848 of them are found to be significantly differentially expressed (DE). Bioinformatics analysis showed that the corresponding genes of these regulated sites are highly associated with sperm motility, providing a connection between the molecular basis and the phenotype of cryodamage. We then performed kinase enrichment analysis and successfully identified glycogen synthase kinase-3α (GSK3A) as the key kinase that may play an important role in the regulation of sperm motility. We further constructed a GSK3A centric network that could help us better understand the molecular mechanism of cryodamage in sperm motility. Finally, we also verified that GSK3A was abnormally activated during this process. The presented phosphoproteome and functional associations provide abundant research resources for us to learn the regulation of sperm functions, as well as to optimize the cryoprotectant for sperm cryopreservation.
Sub-arcsecond LOFAR imaging of Arp 299 at 150 MHz
Authors: Ramírez-Olivencia N. , Varenius E. , Pérez-Torres M. , Alberdi A. , Conway J. E. , Alonso-Herrero A. , Pereira-Santaella M. , Herrero-Illana R. 
Published: October 2021

Context. Arp 299 is the brightest luminous infrared galaxy (LIRG) within 50 Mpc, with IR luminosity log(LIR∕L⊙) = 11.9. It provides a unique laboratory for testing physical processes in merging galaxies.
Aims. We study for the first time the low-frequency (~150 MHz) radio brightness distribution of Arp 299 at subarcsecond resolution, tracing in both compact and extended emission regions the local spectral energy distribution (SED) in order to characterize the dominant emission and absorption processes.
Methods. We analysed the spatially resolved emission of Arp 299 revealed by 150 MHz international baseline Low-Frequency Array (LOFAR) and 1.4, 5.0, and 8.4 GHz Very Large Array (VLA) observations.
Results. We present the first subarcsecond (0.4″ ~ 100 pc) image of the whole Arp 299 system at 150 MHz. The high surface brightness sensitivity of our LOFAR observations (~100 μJy beam−1) allowed us to detect all of the nuclear components detected at higher frequencies, as well as the extended steep-spectrum emission surrounding the nuclei. We obtained spatially resolved, two-point spectral index maps for the whole galaxy: the compact nuclei show relatively flat spectra, while the extended, diffuse component shows a steep spectrum. We fitted the radio SED of the nuclear regions using two different models: a continuous free-free medium model and a clumpy model. The continuous model can explain the SED of the nuclei assuming a population of relativistic electrons subjected to synchrotron, bremsstrahlung, and ionization losses. The clumpy model fits assuming relativistic electrons with negligible energy losses, and thermal fractions that are more typical of star-forming galaxies than those required for the continuous model.
Conclusions. Our results confirm the usefulness of combining spatially resolved radio imaging at both MHz and GHz frequencies to characterize in detail the radio emission properties of LIRGs from the central 100 pc out to the kiloparsec galaxy-wide scales.
A case study of ACV variables discovered in the Zwicky Transient Facility survey
Authors: Faltová N. , Kallová K. , Prišegen M. , Staněk P. , Supíková J. , Xia C. , Bernhard K. , Hümmerich S. , Paunzen E. 
Published: October 2021

Context. Magnetic chemically peculiar (mCP) stars exhibit complex atmospheres that allow the investigation of the interplay of atomic diffusion, magnetic fields, and stellar rotation. A non-uniform surface distribution of chemical elements and the non-alignment of the rotational and magnetic axes result in the variability of several observables. Photometrically variable mCP stars are referred to as α2 Canum Venaticorum (ACV) variables.
Aims. The present work presents a case study of known variables from the Zwicky Transient Facility (ZTF) survey, with the aim of investigating the survey’s suitability for the detection and study of new ACV variables.
Methods. Using suitable selection criteria based on the known characteristics of ACV variables, candidate ACV stars were selected from the ZTF Catalog of Periodic Variable Stars. All light curves were inspected in detail to select the most promising candidates. Where available, low-resolution spectra from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) were employed to classify the stars on the MK system and confirm their status as mCP stars.
Results. We have identified 86 new promising ACV star candidates. Fifteen of these stars have LAMOST spectra available that, in all cases, confirm them as classical mCP stars, which highlights the viability of our approach. We present astrophysical parameters for all sample stars that can be sorted into four subgroups characterized by distinct light curve shapes. Anti-phase variations in different photometric passbands, in particular, are a unique characteristic of a subset of ACV stars readily usable for their identification. The availability of data in three different passbands (g, r, and i) is a major advantage of the ZTF survey.
Conclusions. On the basis of our experience with other photometric surveys and the analysis of light curves, we conclude that the ZTF is well suited to the search for, and the analysis of, ACV variables that are not considered in the available ZTF variable star catalogs. Further work will focus on the development and refinement of a search algorithm to correctly identify these stars in ZTF data and, subsequently, in massive photometric time series databases in general.
Die Bedeutung der Balint-Arbeit in Zeiten des Umbruchs in der
Medizin
Authors: Herzog Philipp 
Published: October 2021

ZusammenfassungIn den letzten 25 Jahren haben die meisten Länder der westlichen Welt
tiefgreifende Veränderungen ihrer Gesundheitssysteme erfahren. Die
Auswirkungen des sozio-ökonomischen Kontexts auf die
Balint-Gruppenarbeit wird herausgearbeitet. Die Ansätze von Enid und
Michael Balint werden verbunden mit den systemtheoretischen und
konstruktivistischen Modellen von Heinz von Förster und Kurt Buchinger.
Das von Förster’sche Modell der „trivialen
Maschine“ dient als Erläuterung, warum im modernen
kommerzialisierten Gesundheitswesen die Balint’schen „Typ
I-Patienten“ bevorzugt werden. „Typ II-Patienten“
hingegen werden entweder zu Typ I Patienten umdefiniert oder ganz aus dem System
eliminiert. Der Zusammenhang zwischen ökonomischem Druck und der
„Übersetzung“ von kranken Individuen in digitale
Algorithmen wird skizziert. Die Arzt-Patient-Beziehung wird als komplexer
Prozess in einem sozio-ökonomischern Kontext definiert, der
Balint‘sche Begriff der Gesamtdiagnose wird aufgegriffen. In dem so dem
entworfenen Modell kommt dem Leiter einer Balint-Gruppe die Aufgabe zu,
für die Teilnehmer als „Experte des Nicht-Wissens“ ein
Rollenmodell zu sein. Balint-Arbeit in diesem Sinne fördert die
„Expertise des Nicht-Wissens“ und ermöglicht so einen
verstehenden Zugang zu Typ II-Patienten, für die es in der digital
konzipierten modernen Medizin keine Theorie und daher nur mangelhafte
diagnostischen und therapeutische Perspektiven gibt.
Der zerrissene Kämpfer: Ein Fahrradunfall mit Schädel-Hirn-
Trauma (SHT)
Authors: Utech Michael 
Published: October 2021

ZusammenfassungDie medizinische Anthropologie des Arztes und Mitbegründers der
Psychosomatik in Deutschland, Viktor von Weizsäcker (1886-1957), ist im
heutigen medizinischen Umfeld weitgehend vergessen oder unbekannt. Dieser
Umstand ist sicher auch der Tatsache geschuldet, dass v. Weizsäcker
keine klar umrissene „Schule“ gegründet hat und die
sprachlich und inhaltlich komplexen Texte eine anhaltende und intensive
Lektüre erfordern – in der modernen Arbeitswelt mit wenig
Zeitreserven eine schwer zu überwindende Hürde. Dennoch lohnt
sich das Wissen um das v. Weizsäcker’sche Denken ganz besonders
in Berufen, in denen Umgangsfragen, wie z. B. zwischen
Arzt/Therapeut und Patient, eine besondere Rolle spielen. Die
medizinische Anthropologie gibt dazu Hinweise und stellt Instrumente bereit, die
im Praxisalltag gewinnbringend Anwendung finden können.Um einen groben Überblick über die medizinische Anthropologie zu
erhalten, werden im folgenden Beitrag zunächst einige grundlegende
Aspekte von zwei Kernkonzepten, dem „Gestaltkreis“ und das
„pathische Pentagramm“, mit seinen fünf Kategorien des
„Dürfens“, „Müssens“,
„Wollens“, „Sollens“ und
„Könnens“ kurz erörtert. Anschließend
wird die in dieser Hinsicht ganzheitlich orientierte Bewegungstherapie am
Beispiel eines Patienten vorgestellt, der nach einem schweren
Schädelhirntrauma u. a. an Schwindelzuständen und
chronischen unspezifischen Kopfschmerzen leidet. Es wird deutlich, in welcher
Weise das Gespräch und die sich wechselseitig beeinflussenden
Begegnungen zwischen den Protagonisten eine entscheidende Rolle spielen.
Illegale Drogenexpositionsfälle im Einzugsbereich des
Giftnotrufs Erfurt (2011 bis 2020)
Authors: Deters Michael , Liebetrau Gesine , Rau Friederike , Prasa Dagmar 
Published: October 2021

Zusammenfassung
Ziel der Studie Wegen starker Veränderungen in den letzten Jahren
wurden die illegalen Drogenexpositionsfälle der letzten 10 Jahre im
Einzugsbereich des Giftnotrufs Erfurt untersucht.
Methodik Retrospektive Analyse oben erwähnter Fälle von
2011 bis 2020 nach Drogenklassen, Symptomschwere, Altersgruppen und
Geschlecht.
Ergebnisse Illegale Drogenmissbrauchsfälle (4963, 2,8%
aller Expositionsfälle) stiegen kontinuierlich von 316 in 2011 auf 614
in 2015 an. Anschließend verringerte sich ihre Fallzahl auf 514 in 2017,
um auf 578 Fälle in 2019 erneut anzusteigen. Im Jahr 2020 gab es einen
leichten Rückgang auf 549 Fälle. Das Fallzahlverhältnis
des Misch- zu Einzelsubstanzkonsums erhöhte sich von 1,0 in 2011 auf 1,7
in 2020. Die Psychostimulantienexpositionsfälle verdoppelten sich von
2011 (168) bis 2020 (319). Expositionsfälle mit Neuen Psychoaktiven
Stoffen (NPS) nahmen von 21 in 2011 auf 126 in 2015 zu und sanken auf 16 in 2020
ab. 320 Drogenexpostionsfälle (6,5%) verliefen schwer, 1902
Fälle (38,3%) mittelschwer und 2139 Fälle
(43,1%) asymptomatisch oder leicht. Hauptsächlich betroffene
Altersgruppen waren Erwachsene mittleren (72,7%) und unbekannten Alters
(12,7%) sowie Jugendliche (12,1%). Männer
(69,9%) waren häufiger als Frauen (26,9%)
involviert.
Schlussfolgerung Die Drogenexpositionsfälle im Einzugsbereich des
Giftnotrufs Erfurt erhöhten sich diskontinuierlich von 2011 bis 2020
durch Anstieg des Mischkonsums. Der zwischenzeitliche Rückgang in den
Jahren 2016 und 2017 wurde durch die Abnahme der NPS-Fälle verursacht.
Daten zu Drogenexpositionsfällen von Giftnotrufzentralen könnten
offizielle Drogenberichte hinsichtlich klinisch-toxikologischer Aspekte
ergänzen.
Diastereoselective Synthesis of the ABCD Ring System of Rubriflordilactone B
Authors: Nicewicz David A. , Roth Hudson G. 
Published: October 2021

AbstractA novel nine-step diastereoselective route to the ABCD ring system of the natural product rubriflordilactone B is reported. Use of an α-substituted butenolide derived from maleic anhydride facilitated a 1,4-conjugate addition to provide a diene. The order in which a ring-closing metathesis and enolate oxidation were performed on this compound dictated the relative stereochemistry of the target. The final product exhibited anisotropic effects during room-temperature NMR studies, requiring elevated-temperature experiments to confirm its identity.
Effect of Polymerization Time and Shade on the Depth of Cure of Nano-Hybrid Resin Composites
Authors: Jabr Noha Abdullah Bin , Al-Saidi Wacim Nassouh , Jabr Ibtessam Abdullah Bin , Al-Bounni Roula Safouh 
Published: October 2021

AbstractObjective The effect of polymerization time and resin shade on the depth of cure (DOC) of two nano-hybrid resin composites (Filtek Z250 XT and IPS Empress Direct) was evaluated and compared.Materials and Methods Sixty specimens were prepared from two shades (A1 and A3) of the resin composites. The specimens were allocated into two groups that were further divided into three subgroups depending on the polymerization time (20, 40, and 60 sec; n = 5). After that, the DOC was evaluated by calculating the polymerized part of the specimen’s thickness to the nearest (0.01 mm) using a high-accuracy micrometer. Each specimen was measured three times, and the corresponding mean reading (in mm) was divided by two to obtain the DOC. The data were analyzed using SPSS software, version 20. Descriptive statistics followed by three-way analysis of variance was applied. Multiple comparisons were made using Scheffe post hoc tests (α = 0.05).Results Filtek Z250 XT-A1-60sec presented with the greatest DOC (7.42 ± 0.47 mm), and the lowest DOC was obtained with IPS Empress-A3-20sec (2.31 ± 0.21 mm). The mean DOC of Filtek Z250 XT and IPS Empress Direct resin composites were 6.18 mm and 3.59 mm, respectively. Statistically significant (p < 0.05) difference was observed between the resin composites. The interaction between independent factors, namely composites, resin shade, and polymerization time, revealed that interaction between them contributed significantly to the DOC (p ≤0.05). However, the interaction between resin shade and the polymerization time was insignificant (p = 0.148).Conclusion Filtek Z250 XT demonstrated greater DOC than IPS Empress Direct resin composite. An increase in polymerization time significantly enhanced the DOC of the resin composites irrespective of the resin shade. Regardless of the resin composite tested, DOC was lower for darker shades (A3).
Successful Primary PCI in Stanford Type A Aortic Dissection Complicated by Inferior ST-Elevation Myocardial Infarction: A Case in a Facility with No Surgical Backup
Authors: Adiarto Suko , Kurnianingsih Novi , Prasetya Indra , Nugroho Faris W. , Uberoi Raman 
Published: October 2021

AbstractMortality of type A aortic dissection (TAAD) complicated with coronary malperfusion syndrome is very high even when emergency surgery is performed. Several reports suggested that primary percutaneous coronary intervention (PPCI) followed by immediate corrective surgery may reduce mortality. In many countries, immediate transfer to an aortic surgery center may not be possible. We report a case of TAAD complicated by coronary malperfusion successfully treated with PPCI followed by elective corrective surgery. A 48-year-old man was referred to emergency department with acute inferior ST-elevation myocardial infarction (STEMI) and underwent PPCI. During the procedure, we realized that the cause of STEMI was TAAD. We decided to continue because the patient experienced seizures and bradycardia. Subsequently, echocardiography and computed tomography confirmed the dissection. The patient was discharged and referred to the National Cardiovascular Center where he underwent successful elective surgery. In this patient, immediate revascularization was lifesaving and served as a bridging procedure before surgical correction.
Attitudes Toward COVID-19 Illness and COVID-19 Vaccination among Pregnant Women: A Cross-Sectional Multicenter Study during August–December 2020
Authors: Battarbee Ashley N. , Stockwell Melissa S. , Varner Michael , Newes-Adeyi Gabriella , Daugherty Michael , Gyamfi-Bannerman Cynthia , Tita Alan T. , Vorwaller Kelly , Vargas Celibell , Subramaniam Akila , Reichle Lawrence , Galang Romeo R. , Powers Emily , Lucca-Susana Miriam , Parks Mickey , Chen Tiffany J. , Razzaghi Hilda , Dawood Fatimah S. 
Published: October 2021

Objective The aim of the study was to evaluate pregnant women's attitudes toward COVID-19 illness and vaccination and identify factors associated with vaccine acceptability.
Study Design This was a cross-sectional survey among pregnant women enrolled in a prospective COVID-19 cohort study in Salt Lake City, UT, Birmingham, AL, and New York, NY, from August 9 to December 10, 2020. Women were eligible if they were 18 to 50 years old and <28 weeks of gestation. Upon enrollment, women completed surveys regarding concerns about COVID-19 illness and likelihood of getting COVID-19 vaccine if one were available during pregnancy. Vaccine acceptability was defined as a response of “very likely” or “somewhat likely” on a 4-point Likert scale. Factors associated with vaccine acceptability were assessed with multivariable logistic regression.
Results Of 939 pregnant women eligible for the main cohort study, 915 (97%) consented to participate. Among these 915 women, 39% self-identified as White, 23% Black, 33% Hispanic, and 4% Other. Sixty-two percent received an influenza vaccine last season. Seventy-two percent worried about getting sick with COVID-19. If they were to get sick, 92% worried about harm to their pregnancy and 80% about harm to themselves. Only 41% reported they would get a vaccine. Of women who were unlikely to get vaccinated, the most frequently cited concern was vaccine safety for their pregnancy (82%). Non-Hispanic Black and Hispanic women had lower odds of accepting a vaccine compared with non-Hispanic White women (adjusted odds ratios [aOR] 0.4, 95% CI 0.2–0.6 for both). Receipt of influenza vaccine during the previous season was associated with higher odds of vaccine acceptability (aOR 2.1, 95% CI 1.5–3.0).
Conclusion Although most pregnant women worried about COVID-19 illness, <50% were willing to get vaccinated during pregnancy. Racial and ethnic disparities in plans to accept COVID-19 vaccine highlight the need to prioritize strategies to address perceived barriers among groups at high risk for COVID-19.
Key Points
Optimization on thermoelectric characteristics of indium tin oxide/indium oxide thin film thermocouples based on screen printing technology
Authors: Tian Bian , Cheng Gong , Zhang Zhongkai , Liu Zhaojun , Zhang Bingfei , Liu Jiangjiang , Li Le , Fan Xu , Lei Jiaming , Zhao Libo , Shi Peng , Lin Qijing , Jiang Zhuangde 
Published: October 2021

In this work, indium tin oxide (ITO)/indium oxide (In2O3) thin film thermocouples (TFTCs) were prepared based on screen printing technology for high temperature measurement. With terpilenol as solvent, epoxy resin and polyether amine as binders and glass powders as additives, the ITO and In2O3 slurries were printed onto the Al2O3 substrate to form thermocouples. The effect on thermoelectric properties of the TFTCs with heat treatment and different contents of additives was investigated through microstructure observation and thermal cycle test. The static calibration experiment shows that the annealed TFTCs with 7.5 wt. % glass powders additives have the maximum Seebeck coefficient. The thermoelectric voltage output of the TFTCs can reach 126.5 mV at 1275 °C while the temperature difference is 1160 °C and the sensitivity of the TFTCs was 109.1 µV/°C. The drift rate of the TFTCs was 8.34 °C/h at a measuring time of 20 min at 1275 °C. The TFTCs prepared via screen printing technology with excellent thermoelectric properties and thermal stability are aimed to be a viable replacement for practical applications.
A direct relationship between the sensitivity of the sensors and the intensity of IR CO2 peak in in situ FTIR-LCR meter chemi-impedance SnO2–carbon nanoparticles polymer-based sensors in the detection of organic compounds vapor
Authors: Okechukwu Viola O. , Mavumengwana Vuyo , Mamo Messai A. 
Published: October 2021

Three sensors were prepared with SnO2, carbon nanoparticles (CNPs), and cellulose acetate (CA) composites, and each sensor containing different amounts of SnO2 powder were prepared for the detection of n-dodecane, 2-hexanone, and 3-methylcyclopentanone vapor at room temperature. Sensors with a combination of CNP:CA, SnO2:CA, SnO2:CNPs, and SnO2 composites were used as control, and their performance was compared with that of the sensor based on SnO2:CNPs:CA toward a wide range of 2-hexanone and 3-methylcyclopentanone vapor concentrations. Sensors based on CNPs:CA and SnO2:CNPs:CA selectively responded very well to 3-methylcyclopentanone and 2-hexanone, respectively. The in situ FTIR study revealed that both sensors undergo a deep oxidation process during sensing and the sensitivity of the sensors directly relates to the IR intensity of the CO2 peak at 668 cm−1, and for highly sensitive sensors, the CO2 peak at 668 cm−1 is found to be very intense. The gradient area under the curve of the IR CO2 band at 668 cm−1 against time for more sensitive sensors toward the analyte is larger than that for less sensitive ones. The effect of the amount of SnO2 in the composites indicated that the sensors based on three sensing materials combined at a mass ratio of 1:1:3 were highly selective toward 3-methylcyclopentanone and less selective toward the other two analytes. Sensors based on the composition of SnO2:CNPs:CA at a mass ratio of 1.5:1:3 and those based on the composition of SnO2:CNPs:CA at a mass ratio of 2:1:3 were selective toward 2-hexanone and n-dodecane, respectively. All the fabricated sensors were found to have their sensing ability regenerated after the analytes were removed from the system without losing their sensing and recovery abilities.