bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of integration in global value chains and the changing structure of employment in Europe
Authors: Bontadini Filippo , Evangelista Rinaldo , Meliciani Valentina , Savona Maria 
Published: December 2021

Abstract
This paper aims at revisiting the empirical evidence on the recent trends of countries’ integration in global value chains (GVCs) in Europe. It investigates two potential sources of unbalances that these processes might relate to (i) the sectoral specialization of the patterns of international fragmentation, whether high-technology manufacturing or knowledge-intensive business services (KIBS), and (ii) the occupational categories that have benefited or been penalized by these trends. A rich empirical mapping of these trends in the European countries is provided, based on World Input–Output Database and European Union Labour Force Survey (EU LFS) data. The results on the overall and sectoral-specific trends of integration in GVCs and the associated changes in the shares of managers and manual workers show dual-speed and qualitatively different integration patterns in Europe, with Eastern European (EE) countries rapidly integrating in high-tech manufacturing and the core of Western countries strengthening their mutual integration in the KIBS area. Despite the relatively “good quality” integration of EE countries, the evidence does not seem to reveal a mirroring upgrading of employment structures. While this empirical contribution does not attempt to identify causal relationships, the picture provided in the paper shows that, overall, integration in GVCs seems to reproduce and perhaps exacerbate the initial asymmetries in the sectoral and employment structure, with employment shares of manual workers reducing on the whole and knowledge-intensive occupations concentrating in Western Europe.
BSAC Vanguard Series: The future role of laboratories in relation to antimicrobial resistance
Authors: Wells David 
Published: December 2021

Abstract
The COVID-19 pandemic has shown that the management of infectious diseases is of global importance. It is clear that a greater more complex pandemic will emerge through antimicrobial resistance (AMR) if we don’t embrace the lessons from this one. Earlier diagnostic testing, in the right place at the right time, using data to drive better public health approaches, should be our response. Proactive diagnostics as a paradigm shift from reactive diagnostics are essential and should be factored into the design of future services. By building on and capitalizing on the lessons on how to handle data, deploy technology and understand the spread of disease, we will improve the response of laboratories, and improve patient outcomes, and through that improve public health. The digital tools of the future will be a huge enabler of this, and this will be made more effective though sharing of data seamlessly. Action needs to be taken now to ensure that this change is implemented at the pace required to tackle AMR.
Hematological and immunological responses to naturally occurring bovine respiratory disease in newly received beef calves in a commercial stocker farm
Authors: Akter Afroza , Caldwell James M , Pighetti Gina M , Shepherd Elizabeth A , Okafor Chika C , Eckelkamp Elizabeth A , Edwards J Lannett , Schneider Liesel G 
Published: December 2021

AbstractThe objective was to determine temporal changes in hematological and immune parameters in response to naturally occurring bovine respiratory disease (BRD) in commercially managed stocker calves. Forty newly weaned beef steers purchased from auction markets were housed at a commercial stocker operation in Crossville, TN. Blood samples, rectal temperature, and thoracic ultrasonography (TUS; 1: normal to 3: severe) were collected on days 0, 7, 14, and 21. Castration status (FC: freshly castrated; PC: previously castrated) was determined on arrival based on presence of a fresh castration site at the scrotum. Calves received antibiotics for BRD based on clinical severity scoring (CSS; 0: moribund, 4: moribund) and rectal temperature. Complete blood counts (CBC) were performed. Calves were categorized based on the number of treatments (NumTrt) received (0x, 1x, and 2x). Temporal variations in CBC and immune parameters were analyzed using mixed model repeated measure ANOVA (Proc GLIMMIX; SAS 9.4). Variation of CBCs and immune parameters based on TUS was determined using mixed model ANOVA. There was a NumTrt by day interaction effect on the responses of white blood cells (WBC) (P = 0.04) and haptoglobin (HPT) (P = 0.04). On day 21, WBC were greater in the 2x NumTrt group than other groups, but there were no differences in WBC between NumTrt levels on other days. Haptoglobin was greater in the 2x group on days 14 and 21 than 0x or 1x. Red blood cells (RBC) (P = 0.02) and WBC (P = 0.04) differed between FC and PC groups, and lower RBC and WBC were observed in the FC group. A castration status × day effect for mean corpuscular volume (MCV; P = 0.04) was observed where FC group had higher MCV at days 14 and 21 than the PC group. Tumor necrosis factor-α differed based on NumTrt (P = 0.03) and higher concentrations were found in 2x group. We observed a day effect for IL-1β (P = 0.009) and TNF-α (P = 0.001). Significant effect of TUS on HPT at day 14 (P = 0.0004) and day 21 (P = 0.002) was observed. Combining HPT and platelet explained 15% of the variability in treatment status on a given day, whereas HPT and hemoglobin explained 10% of the variability in lung consolidation status. Although hematological and immunological parameters varied largely in our study, the potential of combining HPT with hematological variables should be studied further. Results from this study would help in understanding temporal changes in CBC and immune parameters in newly received stocker cattle.
Autologous Skin Cell Suspension Application for Toxic Epidermal Necrolysis: A Case Report
Authors: Pang Alan , Pham Theophilus , Felan Sarah , Raghuram Akshay , Brown Elizabeth , Bharadia Deepak , Griswold John 
Published: December 2021

Abstract
Toxic epidermal necrolysis (TEN) is a drug-mediated disease process that mimics a partial-thickness thermal injury. It has long been treated with frequent wound dressing changes and supportive care. There has been minimal efficacious systemic therapy. The pathophysiology is poorly understood but causes necrosis of keratinocytes at the dermal–epidermal junction leading to sloughing of the epidermis. The disease is rare with high mortality rates associated with long hospital stays. This case report describes the application of autologous skin cell suspension to a patient with TEN after antihypertensive and hyperglycemic therapy. This was associated with minimal wound care and efficacious arrest of patient disease process and timely closure of wound.
Laboratory and Field Evaluations of Two Bait Formulations Against the Invasive Fire Ant, Solenopsis invicta (Hymenoptera: Formicidae)
Authors: Yasudai Rino , Matsubara Akira , Hsu Po-Wei , Lee Ching-Chen , Lin Chung-Chi , Scotty Yang Chin-Cheng 
Published: December 2021

Abstract
The red imported fire ant, Solenopsis invicta Buren, was first discovered in Japan in 2017. As this ant remains at the early invasion stage, efforts in establishing a rapid-response framework, such as evaluating available control methods, are urgently needed. Despite the presence of numerous household insecticides against invasive/household pest ants in Japan, the effects of these products on fire ants remain poorly understood. This study assessed the efficacy of two bait products designed to target common household ant pests in Japan on S. invicta through under laboratory and field conditions in Taiwan. The two baits are Arino-su-korori (AK), a granule-formulated bait product with hydramethylnon as an active ingredient (A.I.), and Hyper Arino-su-korori (HAK), a paste-formulated bait with fipronil as A.I., respectively. We showed that both AK and HAK resulted in more than 99% mortalities of fire ant within 8 wk under laboratory conditions and significantly reduce fire ants’ foraging activities in the field. AK generally performed slightly better than HAK in terms of the time required to achieve total laboratory colony elimination and also long-term suppression of field fire ants. Such differences most likely are attributable to the active ingredient’s mode of action and/or formulation and their interactions with fire ant biology. This study demonstrates the feasibility of the two bait products in effectively controlling laboratory and field fire ants, thus representing a promising candidate pest management tool to cope with ongoing/future fire ant invasions in Japan.
Record Longevity and Reproduction of an African Tick, Argas brumpti (Ixodida: Argasidae)
Authors: Shepherd Julian G 
Published: December 2021

Abstract
Argas brumpti Neumann is a large argasid (soft) tick that inhabits the drier areas of eastern and southern Africa. This species typically feeds on a wide variety of small to large mammals (including humans) and lizards, and resides in shallow caves, rocky areas, or dust-bath areas used by large mammals. Individuals of this species, collected as nymphs and adults from a semidesert area of Kenya and subsequently maintained under constant conditions in the laboratory, survived for 27 yr. Furthermore, after 8 yr of starvation and at least 4 yr after the last male died, at least one female laid eggs. The progeny developed into considerable numbers of both males and females, some of which are still living after 26 yr. The longevity of these ticks is apparently a record for any species of tick. The delay in reproduction likely represents long-term storage of viable sperm, also apparently a record for any species of tick.
Just a Glance, or More? Pathways from Counter-Attitudinal Incidental Exposure to Attitude (De)Polarization Through Response Behaviors and Cognitive Elaboration
Authors: Chen Hsuan-Ting , Kim Yonghwan , Chan Michael 
Published: December 2021

AbstractUsing two-wave U.S. panel survey data, this study proposes a moderated serial mediation model to examine through what paths and under what conditions incidental exposure to counter-attitudinal information on social media would enhance or mitigate polarization. The findings suggest that such exposure can indirectly polarize attitude by eliciting passive scanning behaviors, but it can also indirectly attenuate attitude polarization first through active engagement with the counter-attitudinal information, then through cognitively elaborating on the information. However, the indirect depolarizing effect of incidental exposure to counter-attitudinal information on citizens’ attitude depends on the extent to which they are instrumentally motivated. The indirect effect occurs when an individual’s perceived utility of counter-attitudinal information is at a high and a middle level, but not at a low level. Implications of the findings are discussed.
exp: N-body integration using basis function expansions
Authors: Petersen Michael S , Weinberg Martin D , Katz Neal 
Published: December 2021

ABSTRACT
We present the N-body simulation techniques implemented in the exp code. exp uses empirically chosen basis functions to expand the potential field of an ensemble of particles. Unlike other basis function expansions, the derived basis functions are adapted to an input mass distribution, enabling accurate expansion of highly non-spherical objects, such as Galactic discs. We measure the force accuracy in three models, one based on a spherical or aspherical halo, one based on an exponential disc, and one based on a bar-based disc model. We find that exp is as accurate as a direct-summation or tree-based calculation, and in some ways is better, while being considerably less computationally intensive. We discuss optimizing the computation of the basis function representation. We also detail numerical improvements for performing orbit integrations, including time-steps.
Imaging the structural organization of chemical elements in growth cones of developing hippocampal neurons
Authors: Carmona Asuncion , Chen Si , Domart Florelle , Choquet Daniel , Ortega Richard 
Published: December 2021

AbstractDuring neurodevelopment, neurons form growth cones, F-actin rich extensions located at the distal end of the neurites. Growth cones allow dendrites and axons to build synaptic connections through a process of neurite guidance whose mechanisms have not been fully elucidated. Calcium is an important element in this process by inducing F-actin reorganization. We hypothesized that other biologically active elements might be involved in the growth cone-mediated neurite guidance mechanisms. We performed super resolution and confocal microscopy of F-actin, followed by synchrotron X-ray fluorescence microscopy of phosphorous, sulfur, chlorine, potassium, calcium, iron and zinc on growth cones from primary rat hippocampal neurons. We identified two main patterns of element organization. First, active growth cones presenting an asymmetric distribution of Ca co-localized with the cytoskeleton protein F-actin. In active growth cones, we found that the distributions of P, S, Cl, K, and Zn are correlated with Ca. This correlation is lost in the second pattern, quiescent growth cones, exhibiting a spread elemental distribution. These results suggest that Ca is not the only element required in the F-actin rich active regions of growth cones. In addition, highly concentrated Fe spots of submicrometer size were observed in calcium-rich areas of active growth cones. These results reveal the need for biological active elements in growth cones during neural development and may help explain why early life deficiencies of elements, such as Fe or Zn, induce learning and memory deficits in children.
Targeting radiation-tolerant persister cells as a strategy for inhibiting radioresistance and recurrence in glioblastoma
Authors: Gu Jintao , Mu Nan , Jia Bo , Guo Qingdong , Pan Luxiang , Zhu Maorong , Zhang Wangqian , Zhang Kuo , Li Weina , Li Meng , Wei Lichun , Xue Xiaochang , Zhang Yingqi , Zhang Wei 
Published: December 2021

Abstract

Background
Compelling evidence suggests that glioblastoma (GBM) recurrence results from the expansion of a subset of tumor cells with robust intrinsic or therapy-induced radioresistance. However, the mechanisms underlying GBM radioresistance and recurrence remain elusive. To overcome obstacles in radioresistance research, we present a novel preclinical model ideally suited for radiobiological studies.

Methods
With this model, we performed a screen and identified a radiation-tolerant persister (RTP) subpopulation. RNA sequencing was performed on RTP and parental cells to obtain mRNA and miRNA expression profiles. The regulatory mechanisms among NF-κB, YY1, miR-103a, XRCC3, and FGF2 were investigated by transcription factor activation profiling array analysis, chromatin immunoprecipitation, western blot analysis, luciferase reporter assays, and the MirTrap system. Transferrin-functionalized nanoparticles (Tf-NPs) were employed to improve blood–brain barrier permeability and RTP targeting.

Results
RTP cells drive radioresistance by preferentially activating DNA damage repair and promoting stemness. Mechanistic investigations showed that continual radiation activates the NF-κB signaling cascade and promotes nuclear translocation of p65, leading to enhanced expression of YY1, the transcription factor that directly suppresses miR-103a transcription. Restoring miR-103a expression under these conditions suppressed the FGF2–XRCC3 axis and decreased the radioresistance capability. Moreover, Tf-NPs improved radiosensitivity and provided a significant survival benefit.

Conclusions
We suggest that the NF-κB–YY1–miR-103a regulatory axis is indispensable for the function of RTP cells in driving radioresistance and recurrence. Thus, our results identified a novel strategy for improving survival in patients with recurrent/refractory GBM.
Postrelease survival of captive-bred Egyptian Vultures is similar to that of wild-hatched Egyptian Vultures and is not affected by release age or season
Authors: Efrat Ron , Hatzofe Ohad , Miller Ygal , Mueller Thomas , Sapir Nir , Berger-Tal Oded 
Published: December 2021

AbstractReintroducing species to their historic range or reinforcing extant but endangered populations with individuals from elsewhere are popular conservation efforts to maintain long-term viable populations of animals. These efforts, known as conservation translocations, require proper monitoring of the fate of the animals that are released to assess their success. Nevertheless, effective monitoring is often missing in conservation translocations. Here, we assessed the efficiency of different monitoring methods and estimated survival of captive-bred Egyptian Vultures (Neophron percnopterus) that were released to the wild during the first 15 years of a reintroduction project in Israel. First, we inspected data obtained from different monitoring methods and compared observations of color rings and wing tags to location data from GPS transmitters. Then, we used GPS data to estimate apparent survival of vultures that were released to the wild at different ages and different seasons. Finally, we compared the apparent survival of captive-bred and wild-hatched Egyptian Vultures. We show that only a relatively small portion of the birds were visually observed through color rings and wing tags, compared to those for which data were obtained from GPS transmitters. Using data obtained via GPS transmitters we were able to show that release age and season did not alter apparent survival. In addition, we found no differences in apparent survival between captive-bred and wild-hatched Egyptian Vultures during their first migration or during their first two years postrelease or postfledging. Our results show the importance of continuous and effective monitoring and confirm the efficacy of captive-breeding and release of Egyptian Vultures as a conservation tool. We recommend the continuation of monitoring using GPS transmitters, alongside increased observation-based monitoring efforts.
SPATIAL DISTRIBUTION ANALYSIS AND DOSE ASSESSMENT OF THE RADON EMITTED FROM THE MONAZITE-CONTAINING MATTRESS IN GENERAL RESIDENTIAL SPACE BY CFD METHODS
Authors: Lee Choong Wie , Kim Hee Reyoung 
Published: December 2021

Abstract
Recently, mattresses produced from radon-emitting monazite raw materials in the manufacturing process were found to be releasing radon, and a survey by the Korean Nuclear Safety and Security Commission indicated that some of these products exceeded safety standards. In this study, the distribution of the radon resulting from radon-emitting mattresses was evaluated. The computational fluid dynamics (CFD) code FLUENT was used to analyze the distribution of radon in a general living space, and to assess the exposures of residents. Drawings from the Korea Land and Housing Corporation were analyzed to determine the layout and geometry of the general residential space. Based on the results of the CFD simulation, the distribution of radon in the general residential space was analyzed based on the direction of ventilation and distance from the source. The dose was evaluated to analyze the radiological safety, and was determined to be less than 0.101 mSv per year. These results were in accordance with the reference level of 10 mSv from the International Commission on Radiological Protection recommendation and the annual dose limit of 1 mSv per year for processed products in South Korea.
Perceived Social Support and Symptom Loads of Psychiatric Disorders among Adolescents in Residential Youth Care
Authors: Singstad Marianne T , Wallander Jan L , Lydersen Stian , Kayed Nanna 
Published: December 2021

Abstract
Adolescents in residential youth care (RYC) are at high risk for negative psychological and social development outcomes, as they have a high prevalence of mental health problems and perceive less social support than adolescents in the general population. Associations between perceived social support and mental health problems have been investigated, but no in-depth analyses have been published. Such knowledge is crucial to optimize vulnerable adolescents’ care while living in RYC. The present study, therefore, aims to investigate associations between the symptom load of four psychiatric disorders (the Child and Adolescent Psychiatric Assessment) and perceived social support (the Social Support Questionnaire) among 400 adolescents in Norwegian RYC facilities. The results reveal that a higher number of different types of support persons was associated with lower symptom loads for emotional disorders. In addition, girls reported lower emotional symptoms when perceiving support from their father, friends, and RYC staff, while boys reported more behavioral symptoms with father support and lower behavioral symptoms with staff support. Authors conclude that RYC staff and friends hold important roles in providing social support when parental support is absent. Authors recommend maintenance of social networks for adolescents in RYC and further development of staff members’ relational skills and competence.
Dose Estimation for Exposure to Radioactive Fallout from Nuclear Detonations
Authors: Simon Steven L. , Bouville André , Beck Harold L. , Anspaugh Lynn R. , Thiessen Kathleen M. , Hoffman F. Owen , Shinkarev Sergey 
Published: December 2021

Abstract
In recent years, the prospects that a nuclear device might be detonated due to a regional or global political conflict, by violation of present nuclear weapons test ban agreements, or due to an act of terrorism, has increased. Thus, the need exists for a well conceptualized, well described, and internally consistent methodology for dose estimation that takes full advantage of the experience gained over the last 70 y in both measurement technology and dose assessment methodology. Here, the models, rationale, and data needed for a detailed state-of-the-art dose assessment for exposure to radioactive fallout from nuclear detonations discussed in five companion papers are summarized. These five papers present methods and data for estimating radionuclide deposition of fallout radionuclides, internal and external dose from the deposited fallout, and discussion of the uncertainties in the assessed doses. In addition, this paper includes a brief discussion of secondary issues related to assessments of radiation dose from fallout. The intention of this work is to provide a usable and consistent methodology for both prospective and retrospective assessments of exposure from radioactive fallout from a nuclear detonation.