bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into non-axisymmetric instabilities in three-dimensional rotating supernova models with neutrino and gravitational-wave signatures
Authors: Takiwaki Tomoya , Kotake Kei , Foglizzo Thierry 
Published: September 2021

ABSTRACT
We present a detailed analysis to clarify what determines the growth of the low-T/|W| instability in the context of rapidly rotating core collapse of massive stars. To this end, we perform three-dimensional core-collapse supernova (CCSN) simulations of a 27 M⊙ star including several updates in the general relativistic correction to gravity, the multi-energy treatment of heavy-lepton neutrinos, and the nuclear equation of state. Non-axisymmetric deformations are analyzed from the point of view of the time evolution of the pattern frequency and the corotation radius. The corotation radius is found to coincide with the convective layer in the proto neutron star (PNS). We propose a new mechanism to account for the growth of the low-T/|W| instability in the CCSN environment. Near the convective boundary where a small Brunt–Väisälä frequency is expected, Rossby waves propagating in the azimuthal direction at mid latitude induce non-axisymmetric unstable modes in both hemispheres. They merge with each other and finally become the spiral arm in the equatorial plane. We also investigate how the growth of the low-T/|W| instability impacts the neutrino and gravitational-wave signatures.
Stellar hardening of massive black hole binaries: the impact of the host rotation
Authors: Varisco Ludovica , Bortolas Elisa , Dotti Massimo , Sesana Alberto 
Published: September 2021

ABSTRACT
Massive black hole binaries (MBHBs) with masses of ∼104 to $\sim 10^{10} \, \mathrm{M}_{\odot {}}$ are one of the main targets for currently operating and forthcoming space-borne gravitational wave observatories. In this paper, we explore the effect of the stellar host rotation on the bound binary hardening efficiency, driven by three-body stellar interactions. As seen in previous studies, we find that the centre of mass (CoM) of a prograde MBHB embedded in a rotating environment starts moving on a nearly circular orbit about the centre of the system shortly after the MBHB binding. In our runs, the oscillation radius is ≈ 0.25 (≈ 0.1) times the binary influence radius for equal mass MBHBs (MBHBs with mass ratio 1:4). Conversely, retrograde binaries remain anchored about the centre of the host. The binary shrinking rate is twice as fast when the binary CoM exhibits a net orbital motion, owing to a more efficient loss cone repopulation even in our spherical stellar systems. We develop a model that captures the CoM oscillations of prograde binaries; we argue that the CoM angular momentum gain per time unit scales with the internal binary angular momentum, so that most of the displacement is induced by stellar interactions occurring around the time of MBHB binding, while the subsequent angular momentum enhancement gets eventually quashed by the effect of dynamical friction. The effect of the background rotation on the MBHB evolution may be relevant for LISA sources, that are expected to form in significantly rotating stellar systems.
A speckle-imaging search for close and very faint companions to the nearest and brightest Wolf–Rayet stars
Authors: Shara Michael M , Howell Steve B , Furlan Elise , Gnilka Crystal L , Moffat Anthony F J , Scott Nicholas J , Zurek David 
Published: September 2021

ABSTRACT
Gravitationally bound companions to stars enable determinations of their masses, and offer clues to their formation, evolution, and dynamical histories. So motivated, we have carried out a speckle imaging survey of eight of the nearest and brightest Wolf–Rayet (WR) stars to directly measure the frequency of their resolvable companions, and to search for much fainter companions than hitherto possible. We found one new, close companion to each of WR 113, WR 115, and WR 120 in the separation range ∼0.2–1.2 arcsec2. Our results provide more evidence that similar-brightness, close companions to WR stars are common. More remarkably, they also demonstrate that the predicted, but much fainter and thus elusive companions to WR stars are now within reach of modern speckle cameras on 8-m class telescopes by finding the first example. The new companion to WR 113 is just 1.16 arcsec distant from it, and is ∼8 mag fainter than the WR star. The empirical probability of a chance line of sight of the faint companion at the position of WR 113 is &lt;0.5 per cent, though we cannot yet prove or disprove if the two stars are gravitationally bound. If these three new detections are physical companions we suggest, based on their narrowband magnitudes, colours, reddenings, and GAIA distances that the companions to WR113, WR 115, and WR 120 are an F-type dwarf, an early B-type dwarf, and a WNE-type WR star, respectively.
Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3′ toward 5′, a feature due to a 3′-end binding preference and to structuring of telomeric DNA
Authors: Chatain Jean , Hatem Georges , Delagoutte Emmanuelle , Riou Jean-François , Alberti Patrizia , Saintomé Carole 
Published: September 2021

Abstract
Telomeres are DNA repeated sequences that associate with shelterin proteins and protect the ends of eukaryotic chromosomes. Human telomeres are composed of 5′TTAGGG repeats and ends with a 3′ single-stranded tail, called G-overhang, that can be specifically bound by the shelterin protein hPOT1 (human Protection of Telomeres 1). In vitro studies have shown that the telomeric G-strand can fold into stable contiguous G-quadruplexes (G4). In the present study we investigated how hPOT1, in complex with its shelterin partner TPP1, binds to telomeric sequences structured into contiguous G4 in potassium solutions. We observed that binding of multiple hPOT1–TPP1 preferentially proceeds from 3′ toward 5′. We explain this directionality in terms of two factors: (i) the preference of hPOT1–TPP1 for the binding site situated at the 3′ end of a telomeric sequence and (ii) the cooperative binding displayed by hPOT1–TPP1 in potassium. By comparing binding in K+ and in Li+, we demonstrate that this cooperative behaviour does not stem from protein-protein interactions, but from structuring of the telomeric DNA substrate into contiguous G4 in potassium. Our study suggests that POT1-TPP1, in physiological conditions, might preferentially cover the telomeric G-overhang starting from the 3′-end and proceeding toward 5′.
CTR-DB, an omnibus for patient-derived gene expression signatures correlated with cancer drug response
Authors: Liu Zhongyang , Liu Jiale , Liu Xinyue , Wang Xun , Xie Qiaosheng , Zhang Xinlei , Kong Xiangya , He Mengqi , Yang Yuting , Deng Xinru , Yang Lele , Qi Yaning , Li Jiajun , Liu Yuan , Yuan Liying , Diao Lihong , He Fuchu , Li Dong 
Published: September 2021

AbstractTo date, only some cancer patients can benefit from chemotherapy and targeted therapy. Drug resistance continues to be a major and challenging problem facing current cancer research. Rapidly accumulated patient-derived clinical transcriptomic data with cancer drug response bring opportunities for exploring molecular determinants of drug response, but meanwhile pose challenges for data management, integration, and reuse. Here we present the Cancer Treatment Response gene signature DataBase (CTR-DB, http://ctrdb.ncpsb.org.cn/), a unique database for basic and clinical researchers to access, integrate, and reuse clinical transcriptomes with cancer drug response. CTR-DB has collected and uniformly reprocessed 83 patient-derived pre-treatment transcriptomic source datasets with manually curated cancer drug response information, involving 28 histological cancer types, 123 drugs, and 5139 patient samples. These data are browsable, searchable, and downloadable. Moreover, CTR-DB supports single-dataset exploration (including differential gene expression, receiver operating characteristic curve, functional enrichment, sensitizing drug search, and tumor microenvironment analyses), and multiple-dataset combination and comparison, as well as biomarker validation function, which provide insights into the drug resistance mechanism, predictive biomarker discovery and validation, drug combination, and resistance mechanism heterogeneity.
CovPDB: a high-resolution coverage of the covalent protein–ligand interactome
Authors: Gao Mingjie , Moumbock Aurélien F A , Qaseem Ammar , Xu Qianqing , Günther Stefan 
Published: September 2021

AbstractIn recent years, the drug discovery paradigm has shifted toward compounds that covalently modify disease-associated target proteins, because they tend to possess high potency, selectivity, and duration of action. The rational design of novel targeted covalent inhibitors (TCIs) typically starts from resolved macromolecular structures of target proteins in their apo or holo forms. However, the existing TCI databases contain only a paucity of covalent protein–ligand (cP–L) complexes. Herein, we report CovPDB, the first database solely dedicated to high-resolution cocrystal structures of biologically relevant cP–L complexes, curated from the Protein Data Bank. For these curated complexes, the chemical structures and warheads of pre-reactive electrophilic ligands as well as the covalent bonding mechanisms to their target proteins were expertly manually annotated. Totally, CovPDB contains 733 proteins and 1,501 ligands, relating to 2,294 cP–L complexes, 93 reactive warheads, 14 targetable residues, and 21 covalent mechanisms. Users are provided with an intuitive and interactive web interface that allows multiple search and browsing options to explore the covalent interactome at a molecular level in order to develop novel TCIs. CovPDB is freely accessible at http://www.pharmbioinf.uni-freiburg.de/covpdb/ and its contents are available for download as flat files of various formats.
Obesity and oral health in Mexican children and adolescents: systematic review and meta-analysis
Authors: Aceves-Martins Magaly , Godina-Flores Naara L , Gutierrez-Gómez Yareni Yunuen , Richards Derek , López-Cruz Lizet , García-Botello Marcela , Moreno-García Carlos Francisco 
Published: September 2021

Abstract

Context
A relationship between obesity and poor oral health has been reported.

Objective
To investigate the association between overweight/obesity and oral health in Mexican children and adolescents.

Data Sources
A literature search was conducted of 13 databases and 1 search engine for articles published from 1995 onward.

Data Analysis
A total of 18 publications were included. Evidence was inconclusive and varied according to sociodemographic factors or outcome measuring tools. The Decayed, Missing, and Filled Teeth and Filled Teeth Surfaces indices and the decayed extracted filled teeth index outcomes were included in a random effects model meta-analysis. Pooled estimates showed no statistically significant oral health differences (measured via the decayed extracted filled teeth or the Decayed, Missing, and Filled Teeth Surfaces indexes) among body mass index (BMI) categories. However, pooled estimates of 6 studies showed that children with higher BMI had worse oral health in permanent teeth (measured via the Decayed Missing Filled Teeth Index) than children with lower BMI (overall mean difference, –0.42; 95%CI, –0.74, –0.11).

Conclusion
Whether there is an association between poor oral health and high BMI is inconclusive; however, both co-exist among Mexican children. Therefore, health promotion and prevention efforts should address common risk factors and broader risk social determinants shared between noncommunicable diseases.
Oligocene Leucogranites of the Gangdese Batholith, Southern Tibet: Fractional Crystallization of Felsic Melts from Juvenile Lower Crust
Authors: Zhang Ying-Ze , Wang Xiao-Lei , Li Jun-Yong , He Zhen-Yu , Zhang Feng-Feng , Chen Xin , Wang Shuo , Du De-Hong , Huang Yu , Jiang Chang-Hong 
Published: September 2021

Abstract
The formation of high-silica leucogranites and related detailed evolution of granitic crystal mush in southern Tibet bear significant information on the tectonic and magmatic evolution of the Asian–Indian continent–continent collisional zone. Here, we first report an integrated investigation of the Oligocene (ca. 30 Ma) leucogranites and main body granitoids exposed within the Gangdese Batholith in Gyaca County, southern Tibet. The Gyaca leucogranites can be divided into two groups in terms of field observation (gradational contacts vs. dykes), petrography and geochemistry (plagioclase fractionation vs. accumulation trends), and are characterized by their formation through different stages of evolution from (early) fractionation to (later) accumulation (up to 30%) of plagioclase for Group I and II leucogranites, respectively. Overall, the two groups of leucogranites are both characterized by high SiO2 (71.4–75.7 wt.%), Na2O/K2O (&gt;1.0) and Sr/Y (58–629), and low Rb/Sr (0.02–0.27). The Gyaca main body granitoids resemble the published Gangdese granitoids and most of them also have high Na2O/K2O and they generally show varied SiO2 (64.4–76.1 wt.%) and other major and trace elements. The Gyaca leucogranites and main body granitoids have very similar Sr–Nd–Hf–O isotopic compositions, with initial 87Sr/86Sr ratios from 0.7054 to 0.7064, ɛNd(t) values from −3.40 to +0.65, zircon ɛHf(t) values from −3.0 to +5.2, and zircon δ18O values from 5.59‰ to 6.84‰. These leucogranites and main body granitoids are interpreted to have a same magma source and can be formed by water-present melting of garnet amphibolites from juvenile lower crust plus minor materials from felsic ancient crust beneath the southern Lhasa Terrane. The genetic association of the Oligocene Gyaca leucogranites and main body granitoids and their geochemical diversity reveal an evolved magmatic system. The two types of leucogranites are probably formed by crystal-melt fractionation and plagioclase accumulation at different stages during the solidification of the magma chamber. The discovery of ca. 30 Ma leucogranites in the Gangdese Batholith, in combination with the Oligocene–Miocene high Sr/Y Gangdese granitoids and coeval Himalayan leucogranites (HLGs), indicate the coexistence of diverse granitic rocks in southern Tibet may principally result from partial melting of local deep crustal materials. A new petrogenetic model which illustrates the evolution and multiple emplacements of crystal mush in a granitic magma chamber is proposed for the formation and magmatic evolution of leucogranites in melts from juvenile lower crust in Tibet.
Two galacturonosyltransferases function in plant growth, stomatal development, and dynamics
Authors: Guo Huimin , Xiao Chuanlei , Liu Qing , Li Ruiying , Yan Zhiqiang , Yao Xuan , Hu Honghong 
Published: September 2021

Abstract
The mechanical properties of guard cell (GC) walls are important for stomatal development and stomatal response to external stimuli. However, the molecular mechanisms of pectin synthesis and pectin composition controlling stomatal development and dynamics remain poorly explored. Here, we characterized the role of two Arabidopsis (Arabidopsis thaliana) galacturonosyltransferases, GAUT10 and GAUT11, in plant growth, stomatal development, and stomatal dynamics. GAUT10 and GAUT11 double mutations reduced pectin synthesis and promoted homogalacturonan (HG) demethylesterification and demethylesterified HG degradation, resulting in larger stomatal complexes and smaller pore areas, increased stomatal dynamics, and enhanced drought tolerance of plants. In contrast, increased GAUT10 or GAUT11 expression impaired stomatal dynamics and drought sensitivity. Genetic interaction analyses together with immunolabeling analyses suggest that the methylesterified HG level is important in stomatal dynamics, and pectin abundance with the demethylesterified HG level controls stomatal dimension and stomatal size. Our results provide insight into the molecular mechanism of GC wall properties in stomatal dynamics, and highlight the role of GAUT10 and GAUT11 in stomatal dimension and dynamics through modulation of pectin biosynthesis and distribution in GC walls.
The price of ‘golden’ exploitation: How money flows from the super-rich to domestic workers support inequalities
Authors: Delpierre Alizée 
Published: September 2021

AbstractWealthy people can afford full-time domestic staff at home to be served every day. Some of them spend huge amount of money in domestic service. Working for the rich, domestic workers thus receive wages, gifts and compensations in kind. They can potentially improve their standard of living. Why do super-rich pay so much for their household staff? Following the intuition of Paul Segal about inequality as entitlement over labor, I argue that money as entitlement over labor rests on what I call the ‘golden’ exploitation of the workforce. Substantial rewards do not call into question the exploitative relationship. High value gifts and high salary support exploitation even in situations where it is most likely to be undermined. The case of the ‘super-rich’ domesticity illustrates a hidden production of social inequalities: money compensates for the unlimited drudgery of the employees.
‘The Waste of Daylight’: Rhythmicity, Workers’ Health and Britain’s Edwardian Daylight Saving Time Bills
Authors: Hussey Kristin D 
Published: September 2021

Summary
This article explores an interesting episode in the history of time, health, and modernity: Britain’s 1908 and 1909 Daylight Saving Time (DST) Bills. While the original DST scheme was unsuccessful, the discussions surrounding its implementation reveal tensions central to early twentieth century modernity, namely between industrial time and ‘natural’ bodily rhythms. This article argues that DST was essentially a public health measure aimed at improving the conditions of indoor workers like shop girls and clerks through government regulation of the private time of the labouring classes. Drawing on the extensive evidence provided to two House of Commons Special Committees, this article reveals how DST debates drew together contemporary discussions around sunlight therapy, night work, and the importance of regular sleeping and eating to tackle Britain's endemic urban diseases like consumption and anaemia. I suggest that the idea of bodily rhythms was increasingly important in medical thinking in this period and that the study of rhythmicity points to the potential for incorporating temporality as an analytical category in medical history.
December Is Coming: A Time Trend Analysis of Monthly Variation in Adult Elective Anesthesia Caseload across Florida and Texas Locations of a Large Multistate Practice
Authors: Piersa Anastasia Pozdnyakova , Tung Avery , Dutton Richard P. , Shahul Sajid , Glick David B. 
Published: September 2021

Background
Anesthesia staffing models rely on predictable surgical case volumes. Previous studies have found no relationship between month of the year and surgical volume. However, seasonal events and greater use of high-deductible health insurance plans may cause U.S. patients to schedule elective surgery later in the calendar year. The hypothesis was that elective anesthesia caseloads would be higher in December than in other months.

Methods
This review analyzed yearly adult case data in Florida and Texas locations of a multistate anesthesia practice from 2017 to 2019. To focus on elective caseload, the study excluded obstetric, weekend, and holiday cases. Time trend decomposition analysis was used with seasonal variation to assess differences between December and other months in daily caseload and their relationship to age and insurance subgroups.

Results
A total of 3,504,394 adult cases were included in the analyses. Overall, daily caseloads increased by 2.5 ± 0.1 cases per day across the 3-yr data set. After adjusting for time trends, the average daily December caseload in 2017 was 5,039 cases (95% CI, 4,900 to 5,177), a 20% increase over the January-to-November baseline (4,196 cases; 95% CI, 4,158 to 4,235; P < 0.0001). This increase was replicated in 2018: 5,567 cases in December (95% CI, 5,434 to 5,700) versus 4,589 cases at baseline (95% CI, 4,538 to 4,641), a 21.3% increase; and in 2019: 6,103 cases in December (95% CI, 5,871 to 6,334) versus 5,045 cases at baseline (95% CI, 4,984 to 5,107), a 21% increase (both P < 0.001). The proportion of commercially insured patients and those aged 18 to 64 yr was also higher in December than in other months.

Conclusions
In this 3-yr retrospective analysis, it was observed that, after accounting for time trends, elective anesthesia caseloads were higher in December than in other months of the year. Proportions of commercially insured and younger patients were also higher in December. When compared to previous studies finding no increase, this pattern suggests a recent shift in elective surgical scheduling behavior.

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Persistent Postoperative Opioid Prescription Fulfillment and Peripheral Nerve Blocks for Ambulatory Shoulder Surgery: A Retrospective Cohort Study
Authors: Hamilton Gavin M. , Tierney Sarah , Ramlogan Reva , McCartney Colin J. L. , Bromley Lisa A. , McIsaac Daniel I. 
Published: September 2021

Background
There is need to identify perioperative interventions that decrease chronic opioid use. The authors hypothesized that receipt of a peripheral nerve block would be associated with a lower incidence of persistent postoperative opioid prescription fulfillment.

Methods
This was a retrospective population-based cohort study examining ambulatory shoulder surgery patients in Ontario, Canada. The main outcome measure was persistent postoperative opioid prescription fulfillment. In opioid-naive patients (no opioid prescription fulfillment in 90 days preoperatively), this was present if an individual fulfilled an opioid prescription of at least a 60-day supply during postoperative days 90 to 365. In opioid-exposed (less than 60 mg oral morphine equivalent dose per day within 90 days preoperatively) or opioid-tolerant (60 mg oral morphine equivalent dose per day or above within 90 days preoperatively) patients, this was classified as present if an individual experienced any increase in opioid prescription fulfillment from postoperative day 90 to 365 relative to their baseline use before surgery. The authors’ exposure was the receipt of a peripheral nerve block.

Results
The authors identified 48,523 people who underwent elective shoulder surgery from July 1, 2012, to December 31, 2017, at one of 118 Ontario hospitals. There were 8,229 (17%) patients who had persistent postoperative opioid prescription fulfillment. Of those who received a peripheral nerve block, 5,008 (16%) went on to persistent postoperative opioid prescription fulfillment compared to 3,221 (18%) patients who did not (adjusted odds ratio, 0.90; 95% CI, 0.83 to 0.97; P = 0.007). This statistically significant observation was not reproduced in a coarsened exact matching sensitivity analysis (adjusted odds ratio, 0.85; 95% CI, 0.71 to 1.02; P = 0.087) or several other subgroup and sensitivity analyses.

Conclusions
This retrospective analysis found no association between receipt of a peripheral nerve block and a lower incidence of persistent postoperative opioid prescription fulfillment in ambulatory shoulder surgery patients.

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