bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Theoretical Study of the Effect of Functionalized Pyrene Polymerization on Carbon Electrode Surfaces for Electrochemical Storage
Authors: Anothumakkool Bihag , Sayed‐Ahmad‐Baraza Yuman , Massuyeau Florian , Brousse Thierry , Ewels Chris , Gaubicher Joel 
Published: February 2021

AbstractWe report the effect of −(CH2)n−COOH (n=0,1,3) functional groups on pyrene adsorption and associated electropolymerization mechanisms on carbon nanotube model electrodes, as well as resulting electrochemical charge‐storage properties in a Li metal supercapacitor configuration. The impact of pyrene functional groups is tested by varying the alkyl chain length as well as the composite electrode formulation protocol. From experiment and DFT calculations we conclude that (i) all pyrene derivatives bind strongly to the MWCNT (multiwall carbon nanotube) surface with submonolayer loadings. Intermolecular forces and/or packing configurations rather than charge transfer between MWCNT and substrate likely play a major role in the extent of self‐adsorption process (ii) trends of predicted ionization energies (‐HOMO levels) and Hammett substituent constants match with (measured) oxidation potentials of adsorbed monomers. However, this correlation fails for unsubstituted pyrene presumably because of molecular aggregation, an argument supported by excimer formation in supernatent solutions, (iii) fusion rather than linear‐type oligomerization takes place and is described for the first time and, (iv) longer alkyl chains lead to more extended functionalized oligomers which in turn enhances p‐doping (reversible capacity). In a Li metal hybrid supercapacitor configuration, best capacity‐power compromise was found with 55 wt% 1‐pyreneacetic, resulting in a 5‐fold capacity increase from 13 mAh/gelectrode (19 F/gelectrode) for untreated MWCNT to 68 mAh/gelectrode (102 F/gelectrode) between 2–4.4 V vs. Li+/Li.
Metabolomic analysis improves bioconversion of methanol to isobutanol in Methylorubrum extorquens AM1
Authors: Ma Zeng‐xin , Zhang Min , Zhang Chang‐tai , Zhang Hui , Mo Xu‐hua , Xing Xin‐hui , Yang Song 
Published: February 2021

AbstractBackgroundMethylorubrum extorquens AM1 can be engineered to convert methanol to value‐added chemicals. Most of these chemicals derive from acetyl‐CoA involved in the serine cycle. However, recent studies on methylotrophic metabolism have suggested that C3 pyruvate is a good potential precursor for broadening the types of synthesized products.Methods and ResultsIn the present study, we found that isobutanol was a model chemical that could be generated from pyruvate through a 2‐keto acid pathway. Initially, the engineered M. extorquens AM1 could only produce a trace amount of isobutanol at 0.62 mgL‐1 after introducing the heterologous 2‐ketoisovalerate decarboxylase and alcohol dehydrogenase. Furthermore, the metabolomic analysis revealed that insufficient carbon fluxes through 2‐ketoisovalerate and pyruvate were the key limitation steps for efficient biosynthesis of isobutanol. Based on this analysis, the titer of isobutanol was improved by over 20‐fold after overexpressing alsS gene encoding acetolactate synthase and deleting ldhA gene for lactate dehydrogenase. Moreover, substituting the cell chassis with the isobutanol‐tolerant strain isolated from adaptive evolution of M. extorquens AM1 further increased the production of isobutanol by 1.7‐fold, resulting in the final titer of 19 mgL‐1 in flask cultivation.ConclusionOur current findings provided promising insights into engineering methylotrophic cell factories capable of converting methanol to isobutanol or value‐added chemicals using pyruvate as the precursor.
Development of a simultaneous analytical method for clozapine and its metabolites in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry with linear range adjusted by in‐source collision‐induced dissociation
Authors: Sato Toshihiro , Suzuka Masato , Sato Yuji , Iwabuchi Riko , Kobayashi Daisuke , Ogura Jiro , Takasaki Shinya , Yokota Maki , Tsukamoto Taku , Hayakawa Yoshihiro , Kikuchi Masafumi , Maekawa Masamitsu , Mano Nariyasu 
Published: February 2021

AbstractClozapine (CLZ) is a key drug in treatment‐resistant schizophrenia. Therapeutic drug monitoring (TDM) of CLZ and its metabolites, N‐desmethylclozapine and clozapine N‐oxide, is required to monitor and manage the risks of side effects. Although quantification methods for TDM have been developed for CLZ and its metabolites, they were not sufficiently accurate for the quantification of CLZ owing to the upper limits of the calibration curves. An analytical method using high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry was developed and validated for the simultaneous measurement of CLZ and its metabolites in human plasma. To expand the concentration range of the calibration curves, we used a linear range shift technique using in‐source collision‐induced dissociation (CID). Using our approach, the linearity and quantitative range were improved compared to those reported by previous studies, and were sufficient for TDM in clinical practice. The intra‐ and inter‐assay accuracy was 84.6%–114.8%, and the intra‐ and inter‐assay precisions were ≤9.1% and ≤9.9%, respectively. Moreover, all samples from patients with treatment‐resistant schizophrenia were successfully quantified. Therefore, our novel analytical method using in‐source CID had the appropriate performance to measure the plasma concentrations of CLZ and its metabolites for TDM in clinical practice.
Limited‐edition advertising does not always work for luxury brands: The influence of consumption contexts
Authors: Tseng Ting‐hsiang , Huang Hazel H. , Liu Matthew Tingchi 
Published: February 2021

AbstractLimited‐edition advertising on a limited quantity available to be sold (limited quantity scarcity) is used to increase product value, thereby enticing consumers. This type of limited‐edition advertising has been proven to be effective for luxury brands; as a result, its adoption has increased over the years. However, are limited editions effective across all consumption situations? The current study argues that limited‐edition advertising may not always work as well as previously thought and that it is only effective when (1) consumers are in emotional (vs. cognitive) consumption contexts; (2) the consumption is socially visible (vs. invisible); and (3) the country of origin where the luxury product was made is favorable (vs. unfavorable). The results of two experiments using 807 participants confirmed the study's hypotheses. More importantly, the findings showed that limited‐edition advertising had detrimental effects in a cognitive consumption context; that is, using limited‐edition advertising in a cognitive consumption context decreased consumers' purchase intentions. Theoretical and managerial implications are discussed.
Percutaneous coronary intervention in patients with COVID‐19 and acute coronary syndrome: What if the old normal became the new normal?
Authors: Piccolo Raffaele , Esposito Giovanni 
Published: February 2021

Key Points
The management of COVID‐19 patients with acute coronary syndrome (ACS) remains challenging.
This initial experience supports the safety and efficacy of invasive assessment in patients with COVID‐19 and ACS as well as the safety of the procedure for healthcare personnel.
The study findings raise the question of whether we should continue to follow “COVID‐19 guidelines” suggesting a more conservative approach to ACS patients with COVID‐19 or rather go back to a more unrestricted use of invasive angiography and revascularization.
Interventional closure of aortomitral perforation after TAVR: A case report
Authors: Petri Nils , Lengenfelder Björn , Voelker Wolfram , Nordbeck Peter 
Published: February 2021

AbstractDespite TAVR emerging as the gold standard for a broad spectrum of patients, it is associated with serious complications. In this report we present a case, where a TAVR procedure led to a perforation at the aortomitral continuity, discuss the risk factors for the occurrence of perforations and how we decided to treat the patient.
Necrotizing sialometaplasia—A self‐limiting condition which poses a diagnostic dilemma
Authors: Gupta Abhishek , Priyadarshinee Anamika , Rao Lavanya Nanjunda , Redhu Anju , Jha Kumari Sonam 
Published: February 2021

AbstractNecrotizing sialometaplasia can make anyone very anxious about the lesion especially if they have habit of tobacco consumption. It requires a prompt diagnosis, counseling with assurance to patient and treatment.
Design of Trimetallic NiMoFe Hollow Microspheres with Polyoxometalate‐Based Metal‐Organic Frameworks for Enhanced Oxygen Evolution Reaction
Authors: Yu Zhongyuan , Lin Tong , Zhu Chunfeng , Li Jintang , Luo Xuetao 
Published: February 2021

AbstractDesign of efficient and inexpensive oxygen evolution reaction (OER) catalysts is the key to realizing the wide application of water electrolysis in industrial production. Herein, we synthesized trimetallic hollow microspheres composed with FeNi nanoparticles and nitrogen‐doped carbon‐based Ni2Mo3N (NiMoFe@NC700) using a “PBA@POMOF” strategy. In order to synthesize the precursor with ideal morphology and structure in the least steps, a polyoxometalate based metal‐organic framework (POMOF) is used as a substrate to grow a Ni−Fe‐based Prussian blue analogue (NiFePBA) on it. Benefiting from the hollow sphere structure formed by stacking flakes, better charge transfer performance and the synergistic effect between Ni2Mo3N and Fe0.64Ni0.36, the final product, NiMoFe@NC700, exhibits low overpotentials of 288 and 360 mV to achieve current densities of 10 and 50 mA cm−2 for OER in 1 M KOH, respectively, which is superior to the benchmark IrO2 catalyst. This work proposes a facile and effective strategy to synthetize carbon‐based polymetallic OER electrocatalysts based on PBA@POMOF.
Power‐to‐X‐Anwendungen mit Anschluss an das Stromnetz
Authors: Siebels Carsten 
Published: February 2021

AbstractPower‐to‐X‐Anwendungen (PtX) stehen im Rahmen der Energiewende u. a. deshalb in der Diskussion, da von ihnen erwartet wird, dass durch sie die zeitweise auftretenden Überschüsse elektrischer Energie aus der direkten Nutzung von Sonne und Wind sinnvoll verwertet werden können. Es werden am Beispiel Deutschlands die in den nächsten Jahrzehnten erwartbaren Überschussleistungen und ‐zeiten analysiert. Daneben werden sowohl die zeitgerecht durch Stromerzeugung aus Erneuerbaren Energien abdeckbaren als auch die dadurch ohne Zwischenspeicherung nicht abdeckbaren Anteile der Nachfrage exemplarisch ausgewiesen.
Design and optimization of a CMOS IC novel RF tracking sensor
Authors: Chung Jooik , Iliadis Agis A. 
Published: February 2021

SummaryThis research reports the development of an RF sensor integrated circuit (IC) chip capable of tracking the directionality of RF remote emissions. The IC design uses an angle‐of‐arrival algorithm, and it is designed for the 180 nm CMOS technology and applicable to other technologies, also. The sensor chip requires two pairs of antennas aligned and placed at distance s for detection of azimuthal and polar angles of the RF incident wave. The circuit consists of custom designed low‐noise amplifiers (LNAs) at the front end, with a novel design of double‐balanced Gilbert cell mixers (GCMs). This amplifies and mixes the signals from the antennas and converts the phase difference Δφ into an equivalent output voltage map suitable for an 18‐bit analog to digital converter. Systematic optimization techniques were developed to maximize the third‐order intercept point and suppress flicker noise for the LNAs and GCMs, resulting in improved sensing accuracy. The overall system‐level evaluation results showed state‐of‐art angle‐of‐arrival sensing capability with an upper limit error of 3.447°.
Space charge effects on radiative ultrashort laser‐plasma interactions: Relativistic fluid model
Authors: Mehrabian Somayeh , Ostrikov Kostya (Ken) 
Published: February 2021

AbstractUltrashort laser‐gas interaction is a promising candidate for the intense broad band far‐infrared radiation in which the gas ionization and the resultant plasma formation occur consequently. The electron current produced in the process is the most important influential parameter which affects the far‐infrared radiation generation. Although the interacting forces of the process are the space charge electric and the laser electromagnetic forces, the effect of the former one, has not been investigated on the gas‐plasma THz generation. It is noteworthy that the space charge electric force, due to its effect on the electron distribution, has potential influence on the produced electron current and its consequent emission. Here, a 2D relativistic fluid model is presented in which the ions and the resultant space charge field are incorporated. The model investigates the air ionization, electron‐ion plasma formation, and the system's evolution, spatiotemporally. Moreover, as the model is based on the transient electron current, as the source for the electromagnetic pulse radiation, it gives the temporal profile of the radiated field in which the space charge effects are observable. Our results show that the space charge field affects the electron velocity and its resultant current. Therefore, the temporal profiles and amplitudes of the radiated field components are affected and their resemblance to the experimental data is enhanced. The results indicate that the amplitude of the radiated field increases in the presence of the space charge field. In addition, it is shown that the space charge effects become more pronounced with the laser intensity.
Hospital readmissions of patients with heart failure from real world: timing and associated risk factors
Authors: Wideqvist Maria , Cui Xiaotong , Magnusson Charlotte , Schaufelberger Maria , Fu Michael 
Published: February 2021

AbstractAimsThis study aims to investigate hospital readmissions and timing, as well as risk factors in a real world heart failure (HF) population.Methods and resultsAll patients discharged alive in 2016 from Sahlgrenska University Hospital/Östra, Gothenburg, Sweden, with a primary diagnosis of HF were consecutively included. Patient characteristics, type of HF, treatment, and follow‐up were registered. Time to first all‐cause or HF readmission, as well as number of 1 year readmissions from discharge were recorded. In total, 448 patients were included: 273 patients (mean age 78 ± 11.8 years) were readmitted for any cause within 1 year (readmission rate of 60.9%), and 175 patients (mean age 76.6 ± 13.7) were never readmitted. Among readmissions, 60.1% occurred during the first quarter after index hospitalization, giving a 3 month all‐cause readmission rate of 36.6%. HF‐related 1 year readmission rate was 38.4%. Patients who were readmitted had significantly more renal dysfunction (52.4% vs. 36.6%, P = 0.001), pulmonary disease (25.6% vs. 15.4%, P = 0.010), and psychiatric illness (24.9% vs. 12.0%, P = 0.001). Number of co‐morbidities and readmissions were significantly associated (P < 0.001 for all cause readmission rate and P = 0.012 for 1 year HF readmission rate). Worsening HF constituted 63% of all‐cause readmissions. Psychiatric disease was an independent risk factor for 1 month and 1 year all‐cause readmissions. Poor compliance to medication was an independent risk factor for 1 month and 1 year HF readmission.ConclusionsIn our real world cohort of HF patients, frequent hospital readmissions occurred in the early post‐discharge period and were mainly driven by worsening HF. Co‐morbidity was one of the most important factors for readmission.
Dynamically controlled dielectrophoresis using resonant tuning
Authors: Padhy Punnag , Zaman Mohammad Asif , Jensen Michael Anthony , Hesselink Lambertus 
Published: February 2021

AbstractElectrically polarizable micro‐ and nanoparticles and droplets can be trapped using the gradient electric field of electrodes. But the spatial profile of the resultant dielectrophoretic force is fixed once the electrode structure is defined. To change the force profile, entire complex lab‐on‐a‐chip systems must be re‐fabricated with modified electrode structures. To overcome this problem, we propose an approach for the dynamic control of the spatial profile of the dielectrophoretic force by interfacing the trap electrodes with a resistor and an inductor to form a resonant resistor–inductor–capacitor (RLC) circuit. Using a dielectrophoretically trapped water droplet suspended in silicone oil, we show that the resonator amplitude, detuning, and linewidth can be continuously varied by changing the supply voltage, supply frequency, and the circuit resistance to obtain the desired trap depth, range, and stiffness. We show that by proper tuning of the resonator, the trap range can be extended without increasing the supply voltage, thus preventing sensitive samples from exposure to high electric fields at the stable trapping position. Such unprecedented dynamic control of dielectrophoretic forces opens avenues for the tunable active manipulation of sensitive biological and biochemical specimen in droplet microfluidic devices used for single‐cell and biochemical reaction analysis.
Petrogenesis and tectonic implication of the Late Jurassic Kunyushan granitic complex in the Jiaodong Peninsula, eastern China
Authors: He JiangTao , Li JunJian , Fu Chao , Zhou HongYing , Li XiuZhang , Dang ZhiCai , Tian JiePeng , Tang WenLong 
Published: February 2021

The Kunyushan granitic complex in the Jiaodong Peninsula, East China, is located in the northeast part of the Sulu UHP metamorphic belt. It is the transition belt of the North China Craton and Sulu UHP metamorphic belt. Field relationship and dating results revealed five intrusive phases of the Kunyushan granitic complex were modified into gneissic fine‐grained garnet‐bearing monzogranite (G1), gneissic medium‐ to fine‐grained monzogranite (G2), medium‐ to coarse‐grained monzogranite (G3), medium‐grained monzogranite (G4), and porphyritic coarse‐ to medium‐grained monzogranite (G5). All these phases have similar rock assemblages of peraluminous, calc‐alkaline, I‐type monzogranites. The monzogranites had primitive mantle‐normalized patterns enriched in light rare earth elements (LREE) and lithophile elements (Sr, Ba, and Rb), but depleted in heavy rare earth elements (HREE) and high‐field‐strength elements (Nb, P, and Ti). LA‐ICP‐MS zircon U–Pb dating shows that the crystallization age of the Kunyushan granitic complex extends at least from 157.7–142.0 Ma. The weighted average ages of G1‐G5 were 145.6 ± 1.9 Ma, 145.8 ± 0.5 Ma, 147.2 ± 0.7 Ma, 154.2 ± 0.6 Ma, and 155.0 ± 0.7 Ma, respectively. G5 to G1, from the middle to the edge shows a trend of gradually becoming younger. Zircon grains from different phases have similar 176Hf/177Hf values from 0.281917 to 0.282298, and εHf(t) values from −27.6 to −14.0, with a weighted average of −22.6 ± 0.5, typical of crustal‐derived origin. The corresponding two‐stage model ages TCDM are from 2,910 to 2,066 Ma, with a weighted average of 2,603 ± 31 Ma. Hf–Sr–Nd–Pb isotopes and inherited zircons suggest that the parental magma of the Kunyushan granitic complex was derived from melting of basement rocks of the North China Craton and the Yangtze Craton. The magmatism presumably took place under the background of subduction and back‐arc extension of the Palaeo‐Pacific plate. We infer that the Kunyushan granitic complex was produced by partial melting of the thickened lower crust, through delamination of the thickened lower crust during the Late Jurassic. This magmatic event may mark the beginning of the extensive Mesozoic thinning of the lithosphere in East China.
Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats
Authors: Yegla Brittney , Boles Jake , Kumar Ashok , Foster Thomas C. 
Published: February 2021

AbstractThe role of microglia in mediating age‐related changes in cognition and hippocampal synaptic function was examined by microglial depletion and replenishment using PLX3397. We observed age‐related differences in microglial number and morphology, as well as increased Iba‐1 expression, indicating microglial activation. PLX3397 treatment decreased microglial number, with aged rats exhibiting the lowest density. Young rats exhibited increased expression of pro‐inflammatory cytokines during depletion and repopulation and maintenance of Iba‐1 levels despite reduced microglial number. For aged rats, several cytokines increased with depletion and recovered during repopulation; however, aged rats did not fully recover microglial cell number or Iba‐1 expression during repopulation, with a recovery comparable to young control levels rather than aged controls. Hippocampal CA3–CA1 synaptic transmission was impaired with age, and microglial depletion was associated with decreased total synaptic transmission in young and aged rats. A robust decline in N‐methyl‐d‐aspartate‐receptor‐mediated synaptic transmission arose in young depleted rats specifically. Microglial replenishment normalized depletion‐induced synaptic function to control levels; however, recovery of aged animals did not mirror young. Microglial depletion was associated with decreased context‐object discrimination memory in both age groups, which recovered with microglial repopulation. Aged rats displayed impaired contextual and cued fear memory, and microglial replenishment did not recover their memory to the level of young. The current study indicates that cognitive function and synaptic transmission benefit from the support of aged microglia and are hindered by removal of these cells. Replenishment of microglia in aging did not ameliorate age‐related cognitive impairments or senescent synaptic function.
Financial development and business cycle volatility nexus in theUAE: Evidence fromnon‐linear regime‐shiftand asymmetric tests
Authors: Abosedra Salah , Fakih Ali , Ghosh Sajal , Kanjilal Kakali 
Published: February 2021

AbstractThis paper analyses the dynamics of financial deepening and the volatility of business cycle in the United Arab of Emirates (UAE). We use cointegration tests of regime‐shift with one and two endogenous structural breaks, respectively, using Gregory and Hansen, Oxford Bulletin of Economics and Statistics, 1996, 58, 555–560 and Hatemi‐J, Empirical Economics, 2008, 35, 497–505 approaches. The asymmetry in the underlying relationship of the concerned variables are examined following NARDL model over the period 1974–2016. The findings suggest the presence of regime shifts in the cointegrating relationship and asymmetry between growth volatility and financial deepening. Furthermore, the paper provides evidence of a significant difference in the response of business cycle to negative or positive changes in the financial deepening, which are more pronounced in the short run. Therefore, the obtained asymmetry suggests that business cycle responses are quick and adverse to changes in the financial system in the UAE. The empirical findings of this paper have potential policy implications in this emerging country that is aiming to establish an international reputation in its financial market and become a regional financial hub.
Inside Cover
Authors: Lu Tong , Chen Tingting , Gao Feng , Sun Biao , Ntziachristos Vasilis , Li Jiao 
Published: February 2021

AbstractIn optoacoustic imaging methods, measurement strategies are commonly implemented under limited‐view conditions, leading to artifacts and distortions in reconstructed optoacoustic images. We propose a hybrid data‐driven deep learning approach, termed as LV‐GAN, to efficiently recover high quality images from limited‐view optoacoustic images. The feasibility of LV‐GAN for artifact removal in biological applications and the portability of LV‐GAN was validated by ex vivo experiments based on two different optoacoustic imaging systems.Further details can be found in the article by Tong Lu, Tingting Chen, Feng Gao, Biao Sun, Vasilis Ntziachristos, and Jiao Li (e202000325).
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