bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying a Novel Approach to Scoping Review Incorporating Artificial Intelligence: Mapping the Natural History of Gonorrhoea
Authors: Whelan Jane , Ghoniem Mohammad , Médoc Nicolas , Apicella Mike , Beck Ekkehard 
Published: January 2021

Abstract
BackgroundThis scoping review presents the results of three distinct search strategies combined to identify and map the range of conditions (clinical presentations, complications, coinfections and health problems) associated with gonorrhoea infection. We also report use of a novel artificial-intelligence-(AI)-assisted Medline search tool. MethodsTo fully characterize the range of health outcomes associated with gonorrhoea, we combined a structured preliminary search with a traditional systematic search, then supplemented with the output of a novel AI-assisted Medline search to identify eligible literature. ResultsWe identified 189 health conditions associated with gonorrhoea infection from107 unique references and 21 International Statistical Classification of Diseases and Related Health Problems Ninth and Tenth Revision (ICD 9/10) or Read codes. Pathogenic processes relating to these outcomes were also briefly summarized. The 189 identified health conditions were related to infection of the urogenital tract (n=86), anorectal tract (n=6) oropharyngeal tract (n=5) and the eye (n=14); and other conditions such as systemic (n=61) and neonatal conditions (n=7), psychosocial associations (n=3), and co-infections (n=7). The 107 unique references attained a Scottish Intercollegiate Guidelines Network (SIGN) score of ≥2++ (n=2), 2+ (14 [13%]), 2- (30 [28%]) and 3 (45 [42%]), respectively. Remaining papers (n=16) were reviews. ConclusionsThrough AI screening of Medline, we captured – titles, abstracts, case reports and case series related to rare but serious health conditions. These outcomes might otherwise have been missed during a systematic search. The AI-assisted search provided a useful addition to traditional/manual literature searches especially when rapid results are required.
The Psychometric Properties of the Persian of Miss Nursing Care Tool among Iranian Nurses
Authors: Rahimi Shoeleh , Ebadi Abbas , Khankeh Hamid Reza , Lotfi Mohammad Sajjad 
Published: January 2021

Abstract
Background: Miss nursing care, as an important hidden problem, can disrupt nursing function. Hence, it has been identified as a quality index for nursing care and patient safety recently. Therefore, amounts and types of miss nursing care as well as its reasons have to be explored using a quantitative tool. The present study aimed to investigate the features of the localized miss nursing care tool in 2020.Methods: In this methodological study, miss nursing care tool was translated and back-translated and its face and content validity was assessed by a panel of experts. Then, the tool was distributed electronically among 300 nurses with various experiences working in healthcare centers. The construct validity was evaluated via exploratory factor analysis. Its reliability was also explored using Cronbach’s alpha and Intra-class Correlation Coefficient (ICC).Results: This study was conducted on 300 nurses. The exploratory factor analysis, which resulted in the identification of three factors in the second part of the tool, namely relations, financial resources, and human resources, explaining 79.6% of the total variance. The reliability of the first and second parts of the tool was 0.912 and 0.901, respectively. Additionally, the ICC was found to be 0.687 for the first part and 0.706 for the second part of the tool.Conclusion: The Persian version of the miss care tool benefitted from appropriate validity and reliability. Thus, it could be used as an index for evaluation of clinical nursing care.
Relevance of Connexin 26 (GJB2) Gene Mutations With Congenital Nonsyndromic Sensorineural Hearing Loss in Lraqi Deafness Patients.
Authors: Al-janabi Anwar Madlool , Ahmmed Habeeb Shuhaib , Alkhafaji Salih Mahdi 
Published: January 2021

Abstract
Objective: This study aimed to detect the frequency of the three most common mutations of GJB2 in nonsyndromic sensorineural deafness for Iraqi population.Method: The current case-control study was conducted from January 2018 to November 2019 at ENT Departments from middle Euphrates region of Iraq. The study was included 95 deaf patients group (55 males and 40 females) their age range between 11-40 years old and 21.5 ± 6.3 year (mean ± SD). and 110 healthy control group, their ages range between 10-40 years old and 20.1 ± 5.9 year (mean ± SD), these two groups were matched in age and gender. In order to detect c.35delG, 235delC and 167delT mutations in GJB2 gene, we were employed the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique.Results: From 95 deaf patients with non syndromic hearing loss (NSHL), were participated in this study. The c.35delG was the main frequent mutation encountered with GJB2 gene, of the 95 patients, 38(40%) were heterozygous and the others 57(60%) were homozygous genotypes. The second degree mutation in GJB2 gene was c.235delC mutation. Which from the 95 deaf patients, 35 (36.8%) were carried out homozygous, 5 (5.3%) were carried out heterozygous and 55(57.9) of the study individuals were appeared wild genotypes. None of the 95 deaf patients were showed the c.167delT mutation, while Connexin 26 studied mutations were not detected in healthy control group.Conclusion: Our data conclude that the GJB2 c.35delG and c.235delC gene mutations were the main cause of congenital hearing loss in Iraqi deaf population.
Deficiency of GDF8 Protects Skeletal Muscle Cells from Ischemia Reperfusion Injury
Authors: Wallner Christoph , Drysch Marius , Becerikli Mustafa , Schmidt Sonja , Hahn Stephan , Wagner Johannes , Reinkemeier Felix , Dadras Mehran , Sogorski Alexander , Glinksi Maxi von , Lehnhardt Marcus , Behr Björn 
Published: January 2021

Abstract
Ischemia reperfusion (IR) injury plays a pivotal role in many diseases and leads to collateral damage during surgical interventions. While most studies focus on alleviating its severity in the context of brain, liver, kidney, and cardiac tissue, research as regards to skeletal muscle has not been conducted to the same extent. In the past, GDF8 (myostatin), primarily known for supressing muscle growth, has been implicated in inflammatory circuits, and research provided promising results for cardiac IR injury mitigation by inhibiting GDF8 cell surface receptor ACVR2B. This generated the question if interrupting GDF8 signaling could temper IR injury in skeletal muscle. Examining human specimens from free myocutaneous flap transfer demonstrated increased GDF8 signaling and tissue damage in terms of apoptotic activity, cell death, tissue edema, and lipid peroxidation. In subsequent in vivo MstnLn/Ln IR injury models, we identified potential mechanisms linking GDF8 deficiency to protective effects, among others, inhibition of p38 MAPK signaling and SERCA2a modulation. Furthermore, transcriptional profiling revealed a putative involvement of NK cells. Collectively, this work establishes a protective role of GDF8 deficiency in skeletal muscle IR injury.
Spatiotemporal Patterns and Determinants of Undernutrition Among Late Adolescent Girls in Ethiopia Using Ethiopian Demographic and Health Surveys 2000 to 2016: Spatiotemporal and Multilevel Approach.
Authors: Derseh Nebiyu , Gelaye Kassahun , Muluneh Atalay 
Published: January 2021

Abstract
Introduction: Under-nutrition of late adolescent girls in Ethiopia is the highest among Southern and Eastern African countries. However, the spatial and temporal variations of under-nutrition as a national context is not well understood. This study aimed the spatiotemporal patterns and determinants of under-nutrition among Late Adolescent Girls in Ethiopia.Methods: An in-depth secondary data analysis was conducted from women’s data of four consecutive Ethiopian Demographic and Health Surveys (EDHS) 2000 to 2016. A total of 12,056 late adolescent girls were included in this study. The global spatial autocorrelation was assessed using the Global Moran’s I statistic to evaluate the presence of geographical clustering and variability of undernutrition. The significant cluster scan statistics using Bernoulli model to detect local clusters of significant high rate and low rates of under-nutrition was explored. Multilevel binary logistic regression model with cluster level random effects was fitted to determine factors associated with under-nutrition among Late Adolescent girls in Ethiopia. Results: undernutrition was clustered nationally during each survey (Global Moran’s I=0.009-0.045, Z-score= 5.55-27.24, p value < 0.001). In the final model, individual and community level factors accounted about 31.67% of the variations for under-nutrition. The odds of being under-nourished girls in the age groups of 18 -19 years were 57 % (AOR = 0.43; 95 % CI: 0.35 - 0.53) less likely than those from 15-17 years old. Being in higher educational status was 4.50 times (AOR= 4.50; 95% CI: 2.33–8.69) more likely to be under-nourished compared with no educational status. Undernutrition with occupation of sales was 40% (AOR=0.60; 95% CI: 0.43 – 0.84) lower than those with not working. The odds of being undernourished adolescents were 1.77 times (AOR=1.77; 95% CI: 1.24 - 2.53) higher than participants with unimproved latrine type. Rural residents were 2. 35 times (AOR=2.35; 95% CI: 1.41 - 3.92) more likely to be under nourish compared with urban residents. Conclusion: undernutrition among late adolescent girls was spatially clustered in Ethiopia. The significant high rate of undernutrition was observed in Northern and Eastern Ethiopia. Those regions with high rates of under-nutrition should design interventions to combat under-nutrition.
Acute Care Nurses’ Perceptions of Leadership, Teamwork, Turnover Intention and Patient Safety – A Mixed Methods Study
Authors: Zaheer Shahram , Ginsburg Liane , Wong Hannah , Thomson Kelly , Bain Lorna , Wulffhart Zaev 
Published: January 2021

Abstract
Background This study contributes to a small but growing body of literature on how context influences perceptions of patient safety in healthcare settings. We examine the impact of senior leadership support for safety, supervisory leadership support for safety, teamwork, and turnover intention on overall patient safety grade. Interaction effects of predictors on perceptions of patient safety are also examined.Methods Cross-sectional survey data (N = 185) were collected from nurses and non-physician healthcare professionals. Semi-structured interview data (N = 15) were collected from nurses. The study participants worked in intensive care, general medicine, mental health, or the emergency department of a large community hospital in Southern Ontario.Results Hierarchical regression analyses showed that staff perceptions of senior leadership (p < 0.001), teamwork (p < 0.01), and turnover intention (p < 0.01) were significantly associated with overall patient safety grade. The interactive effect of teamwork and turnover intention on overall patient safety grade was also found to be significant (p < 0.05). The qualitative findings corroborated the survey results but also helped expand the characteristics of the study’s key concepts (e.g., teamwork within and across professional boundaries) and why certain statistical relationships were found to be non-significant (e.g., nurse interviewees perceived the safety specific responsibilities of frontline supervisors much more broadly compared to the narrower conceptualization of the construct in the survey).Conclusions The results of the current study suggest that senior leadership, teamwork, and turnover intention significantly impact nursing staff perceptions of patient safety. Leadership is a modifiable contextual factor and resources should be dedicated to strengthen relational competencies of healthcare leaders. Healthcare organizations must also proactively foster inter and intra-professional collaboration by providing teamwork educational workshops or other on-site learning opportunities (e.g., simulation training). Healthcare organizations would benefit by considering the interactive effect of contextual factors as another lever for patient safety improvement, e.g., lowering staff turnover intentions would maximize the positive impact of teamwork improvement initiatives on patient safety.
A Research on Stress-Induced Deformation of Thin Copper Substrate in Double-Sided Lapping
Authors: Guo Jiang , He Zeng-Xu , Wang Bin , Pan Bo , Bai Qian , Kong Jin-Xing , Kang Ren-Ke 
Published: January 2021

Abstract
Double-sided lapping is an ultra-precision machining method capable of obtaining high-precision surface. However, during the lapping process of thin pure copper substrate, the workpiece will be warped due to the influence of residual stress-related, including the processing stress and initial residual stress, which will deteriorate the flatness of the workpiece and ultimately affect the performance of components. In this study, finite element method (FEM) was adopted to study the effect of residual stress-related on the deformation of pure copper substrate during double-sided lapping. Considering the initial residual stress of the workpiece, the stress caused by the lapping and their distribution characteristics, a prediction model was proposed for simulating workpiece machining deformation in lapping process by measuring the material removal rate of the upper and lower surfaces of the workpiece under the corresponding parameters. The results showed that the primary cause of the warping deformation of the workpiece in the double-sided lapping is the redistribution of initial residual stress caused by uneven removal of double-sided material. The finite element simulation results were in good agreement with the experimental results.
Precipitation and Soil Moisture Datasets Show Severe Droughts in the MENA Region
Authors: Bitar Ahmad Al , Najem Sami , Jarlan Lionel , Zribi Mehrez , Faour Ghaleb 
Published: January 2021

Abstract
The Middle East and North Africa (MENA) region is facing the challenge of lingering droughts. Precipitation and soil moisture are two Essential Climate Variables (ECVs) that are relevant for drought monitoring. We assessed the discrepancies in drought monitoring using remote sensing data from the Tropical Rainfall Measuring Mission (TRMM) and European Space Agency Climate Change Initiative (ESA-CCI) and European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis data (ERA5). A standardized index approach is applied to the four datasets. The indices are spatially and temporally consistent except for the ESA-CCI soil moisture (SM) dataset. The indices depict drought events over the North-West Africa region and show that the TRMM standardized precipitation index (SPI), ERA5 SPI and standardized soil moisture index (SMI) detect drought events in the Near East. A binary classification analysis showed that the indices can accurately and precisely identify drought events across the MENA region except for North East Africa. The indices show that the MENA region was recently under severe to extreme drought conditions, which are driving the exploitation of available water resources in an unsustainable manner. A focus on the Haouz Plain, Morocco, and Aleppo, Syria, shows the critical situation, while the conditions over Al Jazirah, Sudan, are less critical.
As Strong as We Are United: Effects of Intrapersonal and Interpersonal Emotion Regulation on Quality of Life in Women with Breast Cancer
Authors: Moura Rita , Camilo Cristina , Luís Sílvia 
Published: January 2021

Abstract
Background: Women diagnosed with breast cancer are often subjected to negative emotions, resulting in higher levels of emotional burden and decreased levels of well-being and quality of life. The present study aims to compare the implementation of two regulatory levels, intrapersonal and interpersonal (as social sharing of emotions) and explore their impact on breast cancer patients’ perception of quality of life. Methods: Sixty-eight women previously diagnosed with the disease participated in this study, with a mean age of 63 years old (SD = 11.58). Data was collected through a self-report questionnaire to assess emotional experience, intrapersonal regulation, social sharing of emotions and breast cancer-related well-being and quality of life. Results: Data yielded that most of the participants regulated their negative emotions within social interactions and used more antecedent-focused strategies to cognitively reformulate the emotional episode. Moreover, interpersonal regulation had a greater impact on well-being and quality of life than intrapersonal regulation. In particular, the occurrence of sharing episodes and social interactions played an important and beneficial role on patients’ emotion regulation. Conclusions: These findings suggest that social sharing of emotions is an efficient process to help breast cancer patients better cope with the psychological and emotional burden of the disease, thus positively influencing the way they perceive their well-being and quality of life.
Verifying Feeding Tube Placement in Canine and Feline Neonates
Authors: Furthner Etienne , Kowalewski Mariusz , Torgerson Paul , Reichler Iris 
Published: January 2021

Abstract
Background: Tube feeding is a common procedure neonatology. In humans, tube misplacement is reported to occur up to 59% and may lead to perforation in 1.1% of preterm intubated neonates. While numerous studies on optimal tube placement have been performed in human neonates, the current recommendations on tube feeding in canine and feline neonatology are based, at best, on studies made in adults. Our aim is to test ultrasonography as a tool, and to compare different anatomical predictive markers used in human, canine and feline neonates.Results: Predictive tube length when held bent between the last rib to the mouth may induce trauma compared to when held straight. A strong positive linear correlation was found between the birthweight and the localization of the gastric cardia. Ultrasonography, compared to coeliotomy findings were similar. Stomach volume was less than 2 ml per 100 g in the less than one-day-old studied puppies (n= 25) and kittens (n=28).Conclusion: A weight-based equation is proposed to help predicting appropriate tube placement. Ultrasonography can be used as tube placement control. Less than one-day-old neonates have a lower stomach capacity. Further studies are required to evaluate whether older growing animals follow the same correlation compared to the weight. Further in vivo studies are warranted to determine a gold standard procedure for tube feeding in neonatal puppies and kittens.
“We Are Taking Every Precaution to Do Our Part...”: A Comparative Analysis of Nursing, Palliative and Hospice Care Facilities’ Websites During the COVID-19 Pandemic
Authors: Ölcer Sabahat , Idris Mohamed , Yilmaz-Aslan Yüce , Brzoska Patrick 
Published: January 2021

Abstract
Background: The COVID-19 pandemic has a significant impact on health care processes. Precautions such as restrictions imposed on visitors and social distancing have led to multiple challenges, particularly in terms of communication. Using the case of nursing, palliative and hospice care facilities in Germany and drawing on agenda-setting theory, the present study aims to shed light on how health care facilities use their websites to inform (potential) health care users about changes in regulations, new protective measures implemented and about recommendations in the context of the COVID-19 pandemic. Methods: The websites of nursing, palliative and hospice care facilities in Germany were examined using qualitative document analysis and qualitative content analysis. A total of 138 websites was analysed in the study. The data gathered includes all the information about COVID-19 on these websites published from the beginning of March until August 15, 2020. Results: Facilities show similarities in adhering to the measures taken by the authorities to restrict the spread of SARS-CoV-2 and to protect vulnerable patients and employees. The message of avoiding to pay visits to patients in facilities unless there was an emergency was shared between facilities; however, visiting procedures in practice varied by types of facilities. For optimal communication, telephone and especially video calls were the options preferred by healthcare providers and health care users. Facilities made great efforts to prevent emotional stress and to strengthen resilience among all stakeholders. Transparency was adopted by many facilities in order to build the public’s trust. Conclusion: The agenda of health care facilities has been seriously affected by the COVID-19 pandemic. The study sheds light on the strategies developed by facilities, their efforts to increase emotional resilience among health care staff and health care users, the ethical guidelines they have adopted regarding privacy policies as well as how these themes are communicated via the facilities’ websites. The results can inform other health care facilities about how websites can be used as essential communication tools in times of public health crises.
Characterizing the Role of Glycogen Synthase Kinase (GSK)-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways
Authors: Patel Sarvatit , Werstuck Geoff 
Published: January 2021

Abstract
The molecular and cellular mechanisms that link cardiovascular risk factors to the initiation and progression of atherosclerosis are not understood. Recent findings from our laboratory indicate that endoplasmic reticulum (ER) stress signaling through glycogen synthase kinase (GSK)-3α/β induces pro-atherosclerotic pathways. The objective of this study was to define the specific roles of GSK3α and GSK3β in the activation of pro-atherogenic processes in macrophages. Bone marrow derived macrophages (BMDM) were isolated from low-density lipoprotein receptor knockout (Ldlr-/-) mice and Ldlr-/- mice with myeloid deficiency of GSK3α and/or GSK3β. M1 and M2 macrophages were used to examine functions relevant to the development of atherosclerosis, including polarization, inflammatory response, cell viability, lipid accumulation, migration, and metabolism. GSK3α deficiency impairs M1 macrophage polarization, and reduces the inflammatory response and lipid accumulation, but increases macrophage mobility/migration. GSK3β deficiency promotes M1 macrophage polarization, which further increases the inflammatory response and lipid accumulation, but decreases macrophage migration. Macrophages deficient in both GSK3α and GSK3β exhibit increased cell viability, proliferation, and metabolism. These studies begin to delineate the specific roles of GSK3α and GSK3β in macrophage polarization and function. These data suggest that myeloid cell GSK3α signaling regulates M1 macrophage polarization and pro-atherogenic functions to promote atherosclerosis development.