bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification and Longitudinal Trends of Kidney, Renal Cyst, and Renal Parenchyma Volumes in Autosomal Dominant Polycystic Kidney Disease
Authors: KING BERNARD F. , REED JUDD E. , BERGSTRALH ERIK J. , SHEEDY PATRICK F. , TORRES VICENTE E. 
Published: April 2021

Abstract.
The aims of this study were to assess the accuracy and reproducibility of volumetric determinations of total kidney, renal cyst, and renal parenchymal volumes, using fast electron-beam computerized tomography scanning, and to determine the rate of change of these volumes. Nine patients with autosomal dominant polycystic kidney disease (ADPKD) and serum creatinine ≤ 1.3 mg/dl and/or an initial iothalamate clearance ≥ to 60 ml/min per 1.73 m2 were imaged weekly over a 3-wk period (total of 3 times). Approximately 8 yr later, they returned for follow-up studies. The kidney volume estimation technique involved a manual segmentation (perimeter drawing) of the kidneys and a semiautomatic threshold approach, using a histogram analysis of the peak densities of renal parenchyma and renal cysts. At entry, total kidney and renal cyst volumes correlated positively with age, while renal parenchymal volumes and GFR correlated negatively with age. The average coefficient of variation values for the three initial consecutive measurements of total kidney, renal cyst (actual and as a percent of total volume), and renal parenchymal volume were 3.4, 7.2, 5.3, and 5.6%, respectively. During the 8 yr of follow-up, total kidney and renal cyst volumes increased, while renal parenchymal volumes and GFR declined. The rate of increase in total kidney and renal cyst volumes varied markedly from patient to patient. There was a significant correlation between rate of increase in renal cyst volume and the rate of decline in GFR. The patients with an initial urine protein/osmolality ratio >0.13 mg/L per mosmol per kg had a significantly higher increase in renal volume and decline in GFR than those with a lower ratio. In summary, the results of this pilot study suggest that: (1) electron-beam computerized tomography is capable of measuring total kidney, renal cyst, and renal parenchymal volumes reproducibly; (2) total kidney and renal cyst volumes increase, while parenchymal volumes decrease with time; (3) the increase in cyst volume correlates best with the decline in renal function; and (4) renal volumes appear to be good surrogate markers for disease progression in ADPKD.
Energy Transfer Is the Single Most Important Factor for the Difference in Vascular Response between Isolated Ultrafiltration and Hemodialysis
Authors: VAN DER SANDE FRANK M. , GLADZIWA ULRICH , KOOMAN JEROEN P. , BO[Combining Diaeresis]CKER GEORGE , LEUNISSEN KAREL M. L. 
Published: April 2021

Abstract.
Differences in vascular reactivity between isolated ultrafiltration (i-UF) and hemodialysis (UF + HD) have been attributed to various factors, including differences in core temperature (CT) and energy transfer (ET). However, the relative importance of these thermal factors is not known. The aim of this study was to elucidate to what extent differences in ET are responsible for the divergent vascular response between i-UF and UF + HD. During four different dialysis treatments in 15 patients, four measurements were performed that consisted of 1 h of i-UF, UF + HD at a dialysate temperature (T
d) of 37.5°C (UF + HD37.5), UF + HD at T
d 35.5°C (UF + HD35.5), and UF + HD with a similar ET as during i-UF(UF + HDET-set). The UF rate in all sessions was 1 L/h. CT (°C) decreased significantly during i-UF and UF + HDET-set (P < 0.05), increased significantly during UF + HD37.5 (P < 0.05), and remained unchanged during UF + HD35.5 (NS). Forearm vascular reactivity increased significantly during i-UF, UF + HDET-set, and UF + HD35.5 (P < 0.05), but not during UF + HD37.5 (NS). Venous tone increased significantly during i-UF, UF + HD35.5, and UF + HDET-set (P < 0.05), and decreased significantly during UF + HD37.5 (P < 0.05). When i-UF and UF + HD are matched for ET, all differences in vascular response disappear, showing that differences in ET are the single most important factor for the observed difference in vascular response between i-UF and UF + HD. In contrast to UF + HD37.5, vascular reactivity was improved when the increase in CT was prevented during UF + HD35.5 and appeared to increase more when CT was lowered. Preventing the increase in CT during UF + HD appears to be mandatory for optimization of hemodynamic stability during dialysis.
A New Anti-Inflammatory Compound, FR167653, Ameliorates Crescentic Glomerulonephritis in Wistar-Kyoto Rats
Authors: WADA TAKASHI , FURUICHI KENGO , SAKAI NORIHIKO , IWATA YASUNORI , YOSHIMOTO KEIICHI , SHIMIZU MIHO , KOBAYASHI KEN-ICHI , MUKAIDA NAOFUMI , MATSUSHIMA KOUJI , YOKOYAMA HITOSHI 
Published: April 2021

Abstract.
The pathophysiologic effects of FR167653 were investigated in a model of crescentic glomerulonephritis induced by a small dose of nephrotoxic serum in Wistar-Kyoto rats. The rats developed crescentic glomerulonephritis by 6 d after the administration of serum. The subcutaneous administration of FR167653 (32 mg/kg) markedly decreased the severity of the renal damage. In a group of rats treated with FR167653 daily from day 0 to day 6, glomerular damage, including crescent formation and proteinuria, was virtually absent. FR167653 markedly decreased urinary levels of monocyte chemoattractant protein-1 (MCP-1). In addition, FR167653 reduced production of MCP-1 protein and transcripts in the diseased kidneys. In a group of rats for which treatment was initiated on day 3, shortly after the appearance of glomerular abnormalities, the progression of renal disease was appreciably retarded, with partial inhibition of MCP-1. In contrast, when rats were treated only on the first day, no beneficial effects were observed and severe proliferative and necrotizing glomerulonephritis, with crescent formation, was induced by day 6, with the upregulation of MCP-1. These results suggest that FR167653 may be effective against crescentic glomerulonephritis, possibly via the inhibition of MCP-1. In addition, there was marked reduction in renal injury even when FR167653 treatment was initiated after glomerular inflammation was established, suggesting that the therapeutic application of FR167653 may be clinically useful for human renal diseases.
Yerel Yönetimler ve Bütçe İlişkisine Yönelik Akademik Çalışmaların Bibliyometrik Analizi
Authors: AĞCASULU Hülya , YAVUZ İsmail Sadık 
Published: April 2021

Amaç: Bu araştırmanın amacı, yerel yönetimler ve bütçe ilişkisini inceleyen çalışmaların ortak noktalarını bulmak ve literatürün yoğunlaştığı alanları tespit etmektir.
Tasarım/Yöntem: Araştırmada Web of Science servisinin çekirdek kataloğundan elde edilen 1980-2021 dönemine ait yerel yönetimler-bütçe ilişkisine dair 6535 makale VOSviewer yazılımı kullanılarak bibliyometrik ağ analizi ile haritalanmıştır.
Bulgular: Analizler sonucunda; ilgili literatürün Amerika Birleşik Devletleri adresli kurumlar ve yazarlar tarafından şekillendiği; Çin’in geçiş ekonomisi ile ilgili çalışmaların da sayıca fazla olduğu, çalışmaların çoğunlukla ekonomi (2159 çalışma) ve kamu yönetimi (2139 çalışma) alanlarında yoğunlaştığı ve 2004 sonrasında çalışma sayısının üstel bir fonksiyon şeklinde arttığı sonuçlarına ulaşılmıştır.
Sınırlılıklar: Çalışmada kullanılan veri tabanlarının sınırlandırılması 7086 makalenin outlier olarak dışlanması ile sonuçlanmıştır. Outlier parametreleri değiştirilerek interdisipliner karakteristiği artırılmış bir çalışmanın yapılaması mümkün kılacaktır.
Özgünlük/Değer: Çeşitli alanlarda bibliyometrik analizler kullanılmasına rağmen kamu yönetimi-maliye alanlarını birleştiren, yerel yönetimler-bütçe ilişkisini inceleyen interdisipliner ve alanında öncü bir çalışma olması araştırmanın özgün değeridir.
Difusi Kognitif Remaja: Kebutuhan Video Tutorial Latihan Difusi Kognitif
Authors: Eka Wahyuni  , Amelia Gita 
Published: April 2021

Abstrak
Penelitian ini bertujuan untuk mempelajari tingkat fusi kognitif remaja dan alat yang sesuai untuk memfasilitasi latihan difusi kognitif. Convenience sampling digunakan untuk mengumpulkan data dari 199 peserta didik. Instrumen yang digunakan adalah Cognitive Fusion Questionnaire (CFQ-7). Hasil penelitian menunjukkan bahwa 60% remaja mengalami fusi kognitif tinggi (m = 29). Hasil tingkat fusi berdasarkan jenis kelamin, perempuan memiliki tingkat fusi yang lebih tinggi dibandingkan laki-laki (30 vs 28). Persentase perempuan yang mengalami fusi tingkat tinggi melebihi jumlah laki-laki (53% vs 42%). Hasil tingkat fusi berdasarkan sosial ekonomi, tingkat sosial ekonomi rendah memiliki tingkat fusi yang lebih tinggi dibandingkan sosial ekonomi tinggi (34 vs 29). Persentase sosial ekonomi rendah yang mengalami fusi tingkat tinggi melebihi jumlah sosial ekonomi tinggi (75% vs 48%). Sebagian besar peserta didik memiliki eksposur terbatas pada latihan difusi kognitif (-70%) dan semuanya ingin belajar latihan difusi kognitif melalui video. Direkomendasikan bahwa video latihan difusi kognitif dibutuhkan untuk membantu peserta didik dalam meningkatkan kemampuan difusi kognitifnya.
Kata Kunci: Difusi Kognitif, Fusi Kognitif

Abstract
This study aims to explore the level of adolescents’ cognitive fusion and suitable tools to facilitate cognitive defusion exercise. The convenience sampling used to gather the data from 199 students. The instrument used are the Cognitive Fusion Questionnaire (CFQ-7). The results showed that 60% of adolescents experienced high cognitive fusion (m = 29). The result of fusion level based on gender, female has higher level fusion than male (30 vs 28). The percentage of female who experience high level fusion was outnumber male (53% vs 42%). The result of fusion level based on sosial economy, low social economy higher level fusion than high social economy (34 vs 29). The percentage of low social economy who experience high level fusion was outnumber high social economy (75% vs 48%). Most of student has limited exposure to cognitive diffusion exercises (-70%) and all of them eager to learn cognitive defusion exercises through video. It is recommended that cognitive defusion exercise video is needed to help student increase their cognitive defusion skill.
Keyword: Cognitive Defusion, Cognitive Fusion
Heat elution: a modification of the Landsteiner-Miller method
Authors: Dean-El C. , Quraishy N. 
Published: April 2021

Abstract
Elution removes antibodies coating red blood cells and allows for serologic testing of the recovered antibodies. Heat elution may be used in the investigation of ABO hemolytic disease of the fetus and newborn, in the detection of weak A and B antigens in combination with adsorption-elution using polyclonal antibodies, and for the resolution of interfering IgM agglutinating antibodies.
An update on the Scianna blood group system
Authors: Brunker P.A.R. , Flegel W.A. 
Published: April 2021

Abstract
This update of the Scianna blood group system (Brunker PA, Flegel WA. Scianna: the lucky 13th blood group system. Immunohematology 2011;27:41–57) provides the recent work on the genetic variation of ERMAP across more world populations, the elucidation of the molecular basis of an historical serologic case, new cases of antibodies in the system, the development of new serologic reagents, and new discoveries in the biology of the erythroid membrane associated protein (ERMAP). Although genetic variation in ERMAP has been extensively cataloged, nonsynonymous variants associated with alloantigens have remained limited, and no new antigens have been identified. The first case of a severe hemolytic transfusion reaction to anti-Sc2 has recently been reported, highlighting the importance of pursuing the possibility of antibodies to low-prevalence antigens via indirect antiglobulin testing as a routine component of all transfusion reaction investigations. The expanding use of molecular testing in blood centers and transfusion services has uncovered a wider population distribution of Scianna antigens and heightened the awareness of this blood group system. The International Society of Blood Transfusion recognizes seven antigens in the Scianna blood group system 13.
An update on the MNS blood group system
Authors: Castilho L. 
Published: April 2021

Abstract
This update of the MNS blood group system (Reid ME. MNS blood group system: a review. Immunohematology 2009;25:95– 101) reports three new antigens of the MNS system numbered MNS47, MNS48, and MNS49; new glycophorin (GP) variants associated with silent and weak expression of MNS antigens; and the results of new studies on associations of MNS antigens with band 3, Rh proteins, and malaria. The addition of these three antigens brings the total number of antigens in the MNS system (International Society of Blood Transfusion system 2) to 49.
Albumin-indirect antiglobulin test
Authors: Hamilton J.R. 
Published: April 2021

Abstract
Albumin was the first widely used additive solution for hemagglutination tests. Its major effect is to decrease the repulsive forces that keep red blood cells (RBCs) apart. This effect may enable some RBC antibodies, particularly those in the Rh blood group system, to directly agglutinate antigen-positive RBCs after 37°C incubation. The impact of albumin on antibody binding before detection by an indirect antiglobulin test (IAT) is minimal. Use of albumin in antibody identification may help with separation of RBC antibody specificities in a mixture when one or more antibodies demonstrate reactivity after 37°C incubation. Warm autoantibodies can show decreased reactivity in albumin IATs, allowing recognition of underlying alloantibodies.
An update on the Lewis blood group system
Authors: Combs M.R. 
Published: April 2021

Abstract
This update of the Lewis blood group system (Combs MR. Lewis blood group system review. Immunohematology 2009;25:112–8) describes new information on the clinical significance of Lewis antigens regarding susceptibility of individuals to certain diseases and the possible role of bacteria in Lewis expression. This update also describes recently reported examples of Lewis antibodies causing hemolytic transfusion reactions. No new antigens have been identified in the International Society of Blood Transfusion system 7, leaving the antigen count to stand at six: Lea, Leb, LebH, ALeb, BLeb, and Leab.
PROCEEDINGS FROM THE INTERNATIONAL SOCIETY OF BLOOD TRANSFUSION WORKING PARTY ON IMMUNOHAEMATOLOGY, WORKSHOP ON THE CLINICAL SIGNIFICANCE OF RED BLOOD CELL ALLOANTIBODIES, SEPTEMBER 9, 2016, DUBAI: Clinical significance of antibodies to antigens in the ABO, MNS, P1PK, Rh, Lutheran, Kell, Lewis, Duffy, Kidd, Diego, Yt, and Xg blood group systems
Authors: Thornton N.M. , Grimsley S.P. 
Published: April 2021

Abstract
This report is part of a series reporting the proceedings from the International Society of Blood Transfusion (ISBT) Working Party on Immunohaematology Workshop on the Clinical Significance of Red Blood Cell Alloantibodies. The aim of the workshop was to review information regarding the clinical significance of alloantibodies to red blood cell antigens recognized by the ISBT. The first 12 systems will be covered in this report. It is understandable that many of the most clinically important antibodies are directed toward antigens found in the blood group systems discovered earlier in history. The ABO system was the first to be discovered and remains the most clinically important regarding transfusion.
Workshop on the clinical significance of red blood cell alloantibodies organized by the Working Party on Immunohaematology of the International Society of Blood Transfusion
Authors: Peyrard T. 
Published: April 2021

Abstract
A workshop on the clinical significance of red blood cell alloantibodies, organized by the Executive Committee of the Working Party on Immunohaematology of the International Society of Blood Transfusion (ISBT), took place in Dubai, United Arab Emirates, on 9 September 2016, in conjunction with the 34th International Congress of the ISBT. This event was funded by the ISBT Academy, founded in 2011, to support educational and knowledge activities. This report is a summary of that meeting.
Quality improvement with platelet additive solution for safer out-of-group platelet transfusions
Authors: Tynuv M. , Flegel W.A. 
Published: April 2021

Abstract
Isoagglutinins in the plasma of apheresis platelets are a concern. High titer anti-A and anti-B can cause severe hemolytic transfusion reactions. Our facility is testing donor plasma using the gel method to identify isoagglutinin titers exceeding 250. Platelet additive solution (PAS), recently introduced as a collection and storage solution, replaces approximately 65 percent of the plasma in a platelet component. We intended to confirm the effect of PAS on the isoagglutinin titers. We compared the isoagglutinin titers in donor plasma from EDTA-anticoagulated whole blood (without PAS) with the plasma in apheresis platelet components with PAS. Titers were determined in a buffered gel matrix test using serial twofold dilution steps. Among 100 donors tested, 26 plasma samples exceeded a threshold titer of 250; 25 were group O and only one was group B. When samples from these 26 platelet components with PAS were tested, only one group O donor exceeded the threshold titer. Samples from plasma components with PAS consistently showed a 50 percent decrease in titer compared with the donors’ plasma samples. In conclusion, nearly half of the group O donors tested exceeded a titer of 250. Only one apheresis platelet component with PAS exceeded this clinically applied threshold—a 96 percent decrease compared with the number of donor plasma samples without PAS. The implementation of PAS in apheresis platelet components prompted us to revise our component screening process, which then minimized component manipulation of out-of-group platelet transfusions.
Acidification of plasma for detection of pH-dependent antibodies
Authors: Bowman K.L. , Dunlap B.C. , Hawthorne L.M. , Billingsley K.L. 
Published: April 2021

Abstract
Most antibodies to blood group antigens react optimally at a pH range of 6.5–7.5, similar to that of normal plasma or serum. Some antibodies, however, including anti-M, react preferentially or exclusively in an acidic environment with a pH below 6.5. Antibodies with anti-M specificity often show dosage. They can be weakly reactive and even look like nonspecific reactivity at the antihuman globulin phase especially when immediate spin and/or room temperature testing is not part of routine screening. Acidification of serum or plasma may help to identify these antibodies as clinically insignificant versus as an unidentified antibody for which clinical significance is unknown.
Use of trypsin in serologic investigation
Authors: Novotny A. 
Published: April 2021

Abstract
Trypsin is an enzyme first discovered in the quest to increase the detection of newly found Rh antibodies. Because of the crude source of trypsin and challenges in its consistency in test conditions, additional enzymes and chemical treatments were devised as alternative sources to enhance the detection of antibodies. The key to successful trypsin treatment starts with reagent preparation. Optimal testing conditions should be determined with each batch of trypsin prepared. As in all enzyme treatments, quality control is required to ensure proper removal of the expected antigen(s) while not producing enzyme-specific panagglutination. Once successful quality control results have been obtained, trypsin treatment can be used to rule out “common” clinically significant alloantibodies and provide direction in the identification of antibodies to high-prevalence antigens. Trypsin treatment is a key player in the Immunohematology Reference Laboratory but is often overlooked as a tool in the Transfusion Service. If performed using the proper preparation and quality control, trypsin treatment can be a valuable tool in the serology toolkit in both settings.
Clinical approach after identification of a rare anti-Ena in a prenatal sample
Authors: Howard P.J. , Guerra L. , Kuttner D.K. , George M.R. 
Published: April 2021

Abstract
The antigens associated with the MNS blood group system (ISBT 002) are located on glycophorin A (GPA) and glycophorin B (GPB). The most frequently encountered antibodies to antigens in this system by a transfusion medicine service are those directed against M, N, S, and s. Individuals lacking GPA typically have red blood cells that lack M, N, and Ena, whereas those lacking both GPA and GPB lack M, N, and Ena as well as S, s, and U. Such individuals may develop a rare antibody, anti-Ena, directed against determinants on GPA. This antibody is capable of causing hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. This case report describes a pregnant woman found to have anti-Ena. Molecular testing supported an Mk phenotype that was found in several members of her immediate family.
An outcome-based review of an accredited Specialist in Blood Banking (SBB) program: 25 years and counting
Authors: Byrne K.M. , Paige T.D. , Flegel W.A. 
Published: April 2021

Abstract
Specialist in Blood Banking (SBB) programs play an important role in preparing technologists to become leaders and contributors to the field of transfusion medicine through dedicated education and training. The SBB program at the National Institutes of Health (NIH) Clinical Center has graduated 55 students since 1994 with an overall pass rate of 96 percent for the American Society for Clinical Pathology (ASCP) SBB examination. Graduates hold positions in a variety of transfusion medicine–related fields, with hospitals, blood centers, and Immunohematology Reference Laboratories being the most common categories of employer. Projects completed as part of the program added to transfusion medicine knowledge as evidenced by publications and awards. Almost half of all projects completed led to publications (49%), and greater than 50 percent of submissions have been selected for the AABB Future Leaders Scholarship (previously known as AABB Fenwal Scholarship Award). The students have completed over 40 program value-added opportunities. This information was available for retrieval and review. In this review, we analyzed data for the last 25 years from the SBB program at the NIH Clinical Center on program statistics, student accomplishments (such as publications in peer-reviewed journals), program value-added opportunities (such as other publications and audits performed with our Quality Assurance office), and job procurement. The collected, reviewed, and organized data provided a useful internal self-assessment to review the history of our program and head into the future.
May the FORS be with you: a system sequel
Authors: Hult A.K. , Olsson M.L. 
Published: April 2021

Abstract
This article is an update of the review of the FORS system published in Immunohematology in 2017 (Hult AK, Olsson ML. The FORS awakens: review of a blood group system reborn. Immunohematology 2017;33:64–72). This update incorporates the most recently presented knowledge on this still enigmatic system and its genetic, enzymatic, and immunological aspects. Further insight into the genetic variation and allele frequencies of the GBGT1 locus has been reported, and screening studies regarding the prevalence of naturally occurring anti-FORS1 in human plasma have been performed and presented. More basic knowledge on the specificity of the gene product, the Forssman synthase, has been obtained in several detailed studies, and its relation to the homologous ABO gene has been investigated. Taken together, we summarize recently added information about the carbohydrate-based FORS blood group system (International Society of Blood Transfusion number 031).