bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Salmonella effector SifA initiates a kinesin-1 and kinesin-3 recruitment process mirroring that mediated by Arl8a and Arl8b
Authors: Fang Ziyan , Fallet Mathieu , Moest Thomas , Gorvel Jean-Pierre , Méresse Stéphane 
Published: December 2021

ABSTRACT
When intracellular, pathogenic Salmonella reside in a membrane compartment composed of interconnected vacuoles and tubules, the formation of which depends on the translocation of bacterial effectors into the host cell. Cytoskeletons and their molecular motors are prime targets for these effectors. In this study, we show that the microtubule molecular motor KIF1Bβ (a splice variant of KIF1B), a member of the kinesin-3 family, is a key element for the establishment of the Salmonella replication niche as its absence is detrimental to the stability of bacterial vacuoles and the formation of associated tubules. Kinesin-3 interacts with the Salmonella effector SifA but also with SKIP (also known as PLEKHM2), a host protein complexed to SifA. The interaction with SifA is essential for the recruitment of kinesin-3 on Salmonella vacuoles whereas that with SKIP is incidental. In the non-infectious context, however, the interaction with SKIP is essential for the recruitment and activity of kinesin-3 only on a fraction of the lysosomes. Finally, our results show that, in infected cells, the presence of SifA establishes a kinesin-1 and kinesin-3 recruitment pathway that is analogous to and functions independently of that mediated by the Arl8a and Arl8b GTPases.
This article has an associated First Person interview with the first author of the paper.
Signaling Quality with Return Insurance: Theory and Empirical Evidence
Authors: Zhang Chong , Yu Man , Chen Jian 
Published: December 2021

This paper examines an innovative return policy, return insurance, emerging on various shopping platforms such as Taobao.com and JD.com. Return insurance is underwritten by an insurer and can be purchased by either a retailer or a consumer. Under such insurance, the insurer partially compensates consumers for their hassle costs associated with product return. We analyze the informational roles of return insurance when product quality is the retailer’s private information, consumers infer quality from the retailer’s price and insurance adoption, and the insurer strategically chooses insurance premiums. We show that return insurance can be an effective signal of high quality. When consumers have little confidence about high quality and expect a significant gap between high and low qualities, a high-quality retailer can be differentiated from a low-quality retailer solely through its adoption of return insurance. We confirm, both analytically and empirically with a data set consisting of more than 10,000 sellers on JD.com, that return insurance is more likely adopted by higher-quality sellers under information asymmetry. Furthermore, we find that the presence of the third party (i.e., the insurer) leads to double marginalization in signaling, which strengthens a signal’s differentiating power and sometimes renders return insurance a preferred signal, in comparison with free return, whereby retailers directly compensate for consumers’ return hassles. As an effective and costly signal of quality, return insurance may also improve consumer surplus and reduce product returns. Its profit advantage to the insurer is most pronounced under significant quality uncertainty. This paper was accepted by Vishal Gaur, operations management.
A Tale of Two Hierarchies: Interactive Effects of Power Differentiation and Status Differentiation on Team Performance
Authors: Hays Nicholas A. , Li Huisi (Jessica) , Yang Xue , Oh Jo K. , Yu Andrew , Chen Ya-Ru , Hollenbeck John R. , Jamieson Bradley B. 
Published: December 2021

Scholars have long wrestled with whether hierarchical differentiation is functional or dysfunctional for teams. Building on emerging research that emphasizes the distinction between power (i.e., control over resources) and status (i.e., respect from others), we aim to help reconcile the functional and dysfunctional accounts of hierarchy by examining the effects of power differentiation on team performance, contingent on status differentiation. We theorize that power differentiation is dysfunctional for teams with high status differentiation by increasing knowledge hiding, which undermines team performance. In contrast, we predict that power differentiation is functional for teams with low status differentiation by decreasing knowledge hiding, which improves team performance. In a field study, we found that power differentiation harmed team performance via knowledge hiding in teams with high status differentiation, but power differentiation had no effect on knowledge hiding or performance in teams with low status differentiation. In an experiment, we again found that power differentiation harmed team performance by increasing knowledge hiding in teams with high status differentiation. However, power differentiation improved team performance by decreasing knowledge hiding in teams with status equality. Finally, in a third study, we confirm the role of status differentiation in making team climates more competitive and examine the effect of power-status alignment within teams, finding that misalignment exacerbates the dysfunctional effects of power differentiation in teams with high status differentiation. By examining how power and status hierarchies operate in tandem, this work underscores the need to take a more nuanced approach to studying hierarchy in teams. Funding: This research is partially supported by the National Natural Science Foundation of China [Grants 71572079 and 71872086]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2021.1540 .
Enterprise Architecture Planning untuk Pengelolaan Masjid Muhammadiyah
Authors: Fahana Jefree , Umar Rusydi 
Published: December 2021

Majelis Tabligh merupakan unsur pembantu pimpinan yang ditunjuk sebagai penanggungjawab lapangan dalam pengelolaan masjid Muhammadiyah. Sampai tulisan ini hadir, data-data berkait pengelolaan masjid masih belum ada, seperti jumlah masjid se-DIY, kondisi masjid, pengelolaan jamaah, pengelolaan keuangan masjid, dan lainnya.Â Pengawasan terhadap masjid-masjid Muhammadiyah juga masih belum bisa dilakukan, makaÂ perluÂ dukunganÂ sistem informasi/teknologi informasi (SI/TI)Â yang terintegrasi.Â Enterprise ArchitectureÂ adalah gambaran hubungan logis yang terintegrasi antara visi misi, proses bisnis, system informasi, dan infrastruktur organisasi.Â Enterprise Architecture PlanningÂ (EAP) merupakan suatu metode atau kerangka acuan untuk membangun suatu arsitektur informasi yang mengacu pada tujuan atau kebutuhan bisnis organisasi yaitu arsitektur bisnis, arsitektur data, arsitektur aplikasi, arsitektur teknologi. Pada penelitian ini menghasilkan suatu arsitektur bisnis yang teridentifikasi berupa area fungsi, fungsi bisnis, dan proses bisnis Majelis Tabligh. Arsitektur data berupa 10 entitas data. Arsitektur aplikasi berupa 18 aplikasi. Arsitektur Teknologi yang teridentifikasi salahsatunya menggunakanÂ platform webÂ danÂ Mobile.Â Selain itu, didapatkan juga portofolio aplikasi dalam bentuk Mc Farlan Grid.Â The Majelis Tabligh is an auxiliary element to the leadership who is appointed to be in charge of the field in the management of the Muhammadiyah mosque. Until now, there are still no data related to mosque management, such as the number of mosques in Yogyakarta, the condition of mosques, management of congregations, mosque financial management, and others. Supervision of Muhammadiyah mosques is still not possible, so it is necessary to support an information system/information technology (IS / IT) system. Enterprise Architecture is a description of the integrated logical relationship between the vision and mission, business processes, information systems, and organizational infrastructure. Enterprise Architecture Planning (EAP) is a method or frame of reference for building an information architecture that refers to the goals or business needs of the organization, namely business architecture, data architecture, application architecture, technology architecture. This research resulted in an identified business architecture in the form of function areas, business functions, and the Majelis Tabligh business process. The data architecture consists of 10 data entities. The application architecture is in the form of 18 applications. One of the identified technology architectures uses web and mobile platforms. In addition, you can also get a portfolio of applications in the form of the Mc Farlan Grid.
PERFIL SOCIODEMOGRÁFICO DA MORTALIDADE DA POPULAÇÃO IDOSA NO NORDESTE BRASILEIRO
Authors: Perreira Bruna dos Reis , De Jesus Ivia Mayana Oliveira , Martins Maísa Mônica Flores 
Published: December 2021

Introdução: O envelhecimento populacional tem ocorrido de maneira radical e bastante acelerada principalmente nos países em desenvolvimento como o Brasil, esse processo de mudança do perfil demográfico representa um grande desafio para esses países, que precisam rapidamente inserir o tema do envelhecimento populacional na formulação de políticas públicas e de pensar em soluções de reorganização social e de saúde suficientes para atender as necessidades dessa nova realidade populacional. Objetivo: Este estudo tem por objetivo caracterizar o perfil de mortalidade da população idosa do nordeste brasileiro. Materiais e Métodos: O presente projeto trata-se de um estudo ecológico, espaço-temporal, de caráter descritivo a partir de dados secundários de mortalidade da população idosa do nordeste brasileiro, no período de 2006 a 2016. As fontes de dados constituirão de dados contidos nos diversos sistemas de informações disponíveis no Departamento de Informática do Sistema Único de Saúde (DATASUS). Resultados: Foi identificado a partir desse estudo que, o perfil de mortalidade da população idosa é caracterizado principalmente pela sobrecarga das Doenças e Agravos Não Transmissíveis (DANT), e de outros problemas e agravos a saúde como as doenças infecciosas e parasitárias e a desnutrição, que revelam o grau de privação socioeconômica e sanitária que tornam os idosos desta região ainda mais vulneráveis e com mínimas chances de envelhecer ativamente e com qualidade de vida. Conclusão: Conclui-se que, essas informações são instrumentos imprescindíveis para o monitoramento das condições de vida e saúde, na orientação de estratégias de prevenção desses eventos, além de possibilitar o reconhecimento das demandas e padrões de serviços de saúde da população idosa para o planejamento, elaboração e avaliação de políticas de saúde.
Spatial distribution and factors associated with modern contraceptive use among women of reproductive age in Nigeria: A multilevel analysis
Authors: Bolarinwa Obasanjo Afolabi , Tessema Zemenu Tadesse , Frimpong James Boadu , Seidu Abdul-Aziz , Ahinkorah Bright Opoku 
Published: December 2021

Background
Evidence suggests that in countries with high fertility and fecundity rates, such as Nigeria, the promotion of modern contraceptive use prevents approximately 32% and 10% of maternal and child mortality, respectively. Therefore, this study aimed to assess the spatial distribution of modern contraceptive use and its predictors among women of reproductive age in Nigeria.

Methods
The study employed a cross-sectional analysis of population-based data involving 24,281 women of reproductive age in Nigeria. The study adopted both multilevel and spatial analyses to identify the predictors of modern contraceptive use and its spatial clustering among women in Nigeria.

Results
Modern contraceptive use among the study population in Nigeria ranged from 0% to 75%, with regional variations. The spatial analysis showed that areas with a low proportion of modern contraceptive use were Sokoto, Yobe, Borno, Katsina, Zamfara, Kebbi, Niger, Taraba and Delta. Areas with a high proportion of modern contraceptive use were Lagos, Oyo, Osun, Ekiti, Federal capital territory, Plateau, Adamawa, Imo, and Bayelsa. The multilevel analysis revealed that at the individual level, women with secondary/higher education, women from the Yoruba ethnic group, those who had four children and above, and those exposed to mass media had higher odds of using modern contraceptives. On the other hand, women who were 35 years and above, those who were married, and women who were practicing Islam were less likely to use modern contraceptives. At the household/community level, women from the richest households, those residing in communities with medium knowledge of modern contraceptive methods, and women residing in communities with a high literacy level were more likely to use modern contraceptives.

Conclusion
There were major variations in the use of modern contraception across various regions in Nigeria. As a result, areas with low contraceptive rates should be given the most deserving attention by promoting contraceptive education and use as well as considering significant factors at the individual and household/community levels.
Trends in extent of surgical cytoreduction for patients with ovarian cancer
Authors: Wong Deanna H. , Mardock Alexandra L. , Manrriquez Erica N. , Lai Tiffany S. , Sanaiha Yas , Sinno Abdulrahman K. , Benharash Peyman , Cohen Joshua G. 
Published: December 2021

Purpose
To identify patient and hospital characteristics associated with extended surgical cytoreduction in the treatment of ovarian cancer.

Methods
A retrospective analysis using the National Inpatient Sample (NIS) database identified women hospitalized for surgery to remove an ovarian malignancy between 2013 and 2017. Extended cytoreduction (ECR) was defined as surgery involving the bowel, liver, diaphragm, bladder, stomach, or spleen. Chi-square and logistic regression were used to analyze patient and hospital demographics related to ECR, and trends were assessed using the Cochran-Armitage test.

Results
Of the estimated 79,400 patients undergoing ovarian cancer surgery, 22% received ECR. Decreased adjusted odds of ECR were found in patients with lower Elixhauser Comorbidity Index (ECI) scores (OR 0.61, p<0.001 for ECI 2, versus ECI≥3) or residence outside the top income quartile (OR 0.71, p<0.001 for Q1, versus Q4), and increased odds were seen at hospitals with high ovarian cancer surgical volume (OR 1.25, p<0.001, versus low volume). From 2013 to 2017, there was a decrease in the proportion of cases with extended procedures (19% to 15%, p<0.001). There were significant decreases in the proportion of cases with small bowel, colon, and rectosigmoid resections (p<0.001). Patients who underwent ECR were more likely treated at a high surgical volume hospital (37% vs 31%, p<0.001) over the study period. For their hospital admission, patients who underwent ECR had increased mortality (1.6% vs. 0.5%, p<0.001), length of stay (9.6 days vs. 5.2 days, p<0.001), and mean cost ($32,132 vs. $17,363, p<0.001).

Conclusions
Likelihood of ECR was associated with increased medical comorbidity complexity, higher income, and undergoing the procedure at high surgical volume hospitals. The proportion of ovarian cancer cases with ECR has decreased from 2013–17, with more cases performed at high surgical volume hospitals.
A worldwide systematic review and meta-analysis of bacteria related to antibiotic-associated diarrhea in hospitalized patients
Authors: Motamedi Hamid , Fathollahi Matin , Abiri Ramin , Kadivarian Sepide , Rostamian Mosayeb , Alvandi Amirhooshang 
Published: December 2021

IntroductionAntibiotic-associated diarrhea (AAD) is a major hospital problem and a common adverse effect of antibiotic treatment. The aim of this study was to investigate the prevalence of the most important bacteria that cause AAD in hospitalized patients.Materials and methodsPubMed, Web of Science and Scopus databases were searched using multiple relevant keywords and screening carried out based on inclusion/exclusion criteria from March 2001 to October 2021. The random-effects model was used to conduct the meta-analysis.ResultsOf the 7,377 identified articles, 56 met the inclusion criteria. Pooling all studies, the prevalence ofClostridioides(Clostridium)difficile,Clostridium perfringens,Klebsiella oxytoca, andStaphylococcus aureusas AAD-related bacteria among hospitalized patients were 19.6%, 14.9%, 27%, and 5.2%, respectively. The prevalence of all four bacteria was higher in Europe compared to other continents. The highest resistance ofC.difficilewas estimated to ciprofloxacin and the lowest resistances were reported to chloramphenicol, vancomycin, and metronidazole. There was no or little data on antibiotic resistance of other bacteria.ConclusionsThe results of this study emphasize the need for a surveillance program, as well as timely public and hospital health measures in order to control and treat AAD infections.
An innovative approach to game-based learning in nursing education: Virtual gaming simulation
Authors: Ordu Yadigar , Çalışkan Nurcan 
Published: December 2021

Nursing education includes cognitive, affective and psychomotor learning areas that enable students to take on certain roles. Reasons such as limited clinical applications, patients' reluctance to have students practice and the low number of teaching staff negatively affect the development of students. For this reason, technological developments are integrated into the nursing education curriculum and it is tried to provide knowledge and skills to students in a safer and more effective way. Game-based learning is becoming more and more common in the education of nursing students who grow up in the age of technology. Game-based learning provides permanence in knowledge, supports active learning and increases student satisfaction. Recently, one of the applications involving technology in nursing education is virtual game simulation. Virtual game simulation is a 2D (two-dimensional) virtual computer game involving simulated real people, allowing students to actively participate in a clinical scenario. Virtual simulation games are designed with realistic scenarios for students to experience the clinical environment, improve their self-confidence, critical thinking and clinical decision making skills. The aim of this article is to explain virtual game simulation, which is a new approach in game-based learning in nursing education, and research on the subject.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Hemşirelik eğitimi öğrencilere belirli rolleri üstlenmelerini sağlayacak düzeyde bilişsel, duyuşsal ve psikomotor öğrenim alanlarını içermektedir. Sınırlı klinik uygulamalar, hastaların öğrencilere uygulama yaptırmak istememesi ve öğretim elemanı sayısının az olması gibi nedenler ise öğrencilerin gelişimini olumsuz etkilemektedir. Bu nedenle yaşanan teknolojik gelişmeler hemşirelik eğitim müfredatına entegre edilerek öğrencilere bilgi ve beceri öğretimi daha güvenli ve etkin bir şekilde sağlanmaya çalışılmaktadır. Teknoloji çağında yetişen hemşirelik öğrencilerinin eğitiminde oyun temelli öğrenme giderek yaygınlaşmaktadır. Oyun temelli öğrenme, bilgide kalıcılığı sağlayarak aktif öğrenmeyi desteklemekte ve öğrenci memnuniyetini artırmaktadır. Son zamanlarda hemşirelik eğitiminde teknolojiyi içeren uygulamalardan biri sanal oyun simülasyonudur. Sanal oyun simülasyonu, öğrencilerin klinik bir senaryoya aktif katılımını sağlayan, simüle edilmiş gerçek insanları içeren 2D (iki boyutlu) bir sanal bilgisayar oyunudur. Sanal simülasyon oyunları gerçeğe yakın senaryolar ile öğrencilerin klinik ortamı deneyimlemesi, özgüvenlerinin, eleştirel düşünme ve klinik karar verme becerilerinin geliştirilmesi amacıyla tasarlanmıştır. Bu makalenin amacı, hemşirelik eğitiminde oyun temelli öğrenmede yeni bir yaklaşım olan sanal oyun simülasyonunu ve konu ile ilgili yapılan araştırmaları açıklamaktır.
Presence of short and cyclic peptides in Acacia and Ziziphus honeys may potentiate their medicinal values
Authors: ALaerjani Wed Mohammed Ali , Abu-Melha Saraa Abdullah , Khan Khalid Ali , Ghramh Hamed A. , Alalmie Ali Yahya A. , Alshareef Rahaf Mohammed Hussein , AL-Shehri Badria M. , Mohammed Mohammed Elimam Ahamed 
Published: December 2021

Abstract
Acacia honey is characterized by high nutritional, antioxidant, antibacterial and immuno-modulatory values. This work investigated the presence of short and cyclic peptides in Acacia and Ziziphus honey samples. Acacia honey samples (Acacia tortilis and Acacia hamulosa) and three Ziziphus honeys (Ziziphus spina-christi) were screened for their short and cyclic peptide contents using the LC-MS and the chemical structure databases. Moreover, the total protein content was determined using the Bradford method. The A. tortilis honey contained three short peptides; HWCC, DSST, and ECH, and the A. hamulosa honey sample contained five short peptides and one cyclic peptide. The short peptides of the A. hamulosa honey were Ac-GMGHG-OH (Ac-MGGHG-OH), Boc-R(Aloc)2-C(Pal)-OH, H-C (1)-NEt2·H-C (1)-NEt2, APAP (AAPP), and GAFQ (deamino-2-pyrid-4-yl-glycyl-dl-alanyl-dl-norvalyl-dl-asparagine). The cyclic peptide of the A. hamulosa honey was cyclo[Aad-RGD-d-F] (cyclo[Aad-Arg-Gly-Asp-d-Phe]). The Ziziphus honey was characterized by the presence of either Almiramide B or Auristatin-6-AQ. A. tortilis, A. hamulosa, and Ziziphus honeys are characterized by the presence of short and cyclic peptides which may contribute to their medicinal values.
Effect of concrete and reinforcement continuity on repairing mid-span zone in simply supported one-way slab
Authors: Kadhim Muhammad Jawad , Shadhan Khalid K. , Al-Zahra Bilal Ismaeel Abd 
Published: December 2021

AbstractThe flexural strength of slabs may be reduced due to accidents and environmental effects. This study focuses on the rehabilitation of the one-way reinforced concrete slab. Experimental works include five simply supported one-way reinforced concrete slabs with width, depth, and length of 400, 120, and 2200 mm, respectively. Different configurations of steel continuity between old and new concrete have been tested. Moreover, in the control specimen (steel is continued overall, the specimen and concrete are cast in one stage over the entire slab). In the other four specimens, the concrete is cast in two stages, the left and right parts representing the old concrete are cast first, and the middle part representing a new concrete is cast after that. In these four specimens, new steel is connected to old one by different configuration (original steel remain to continue, new steel connected to old one by weld, new steel connected to old one by making 90° hooks, and new steel bars is put inside bores using epoxy). After testing, the welding method of connecting new to old steel is the best one.
The Collateral Directive and Financial Collateral: Ownership of, or entitlement to, collateral?
Authors: Ezike Obiora 
Published: December 2021

Abstract
It is controversial if incorporeal moveables (or choses in action) can be the object of property rights. The Collateral Directive arguably attempts to take the middle-ground in this debate. It acknowledges that a person may have either ‘full ownership of’, or 'full entitlement' to, financial collateral, which are conceptualised as intangibles. The approach adopted by the Directive throws up some questions: Is there a difference between owning or being entitled to collateral? If there is a difference, does this matter? The article first highlights the underlying controversy between these two concepts: which arises because of the different conceptions of real rights, or right in rem, and the need to protect the boundary between real and personal rights. The article then argues that although ‘owning’ and ‘entitlement’ are different concepts, there are also functional similarities between both concepts which arguably the Directive extends further than necessary.