bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medio siglo de visual merchandising en el retail textil: la inversión para crecer en el mercado que viene
Authors: Llovet Rodríguez Carmen 
Published: October 2021

Alcance de la revisión: Esta investigación realiza una revisión del rol del visual merchandising en el retail textil para su aplicación en el entorno actual, definido por el sector como la primera gran transformación del retail por los cambios acelerados por la pandemia en toda la cadena de valor (de la fórmula dependiente-mostrador- cliente) en 200 años.
Período de las publicaciones revisadas: Se analizan las investigaciones que entre 1980 y 2020 subrayan el uso de la tienda como elemento de comunicación y marketing. El punto de partida es la década de los 80, cuando se dio la primera revolución destacada en la tienda: Benetton eliminó mostradores y cajas y dispuso las camisetas por colores sin necesidad de vendedor.
Origen y tipos de documentos revisados: Se revisan artículos de revistas indexadas y manuales especializados en las áreas de marketing, consumo, comunicación, distribución y diseño, presentes en bases de datos nacionales e internacionales y en la Biblioteca Nacional de España.
Aportación del autor a las publicaciones analizadas: El estudio identifica las funciones del visual merchandising para responder a la necesidad de los retailers de adaptarse a las altas expectativas de los consumidores, vinculadas a las innovaciones tecnológicas en el diseño y en el ambiente o a decisiones de compra basadas en estímulos externos, más rápidas y menos motivadas por un esfuerzo cognitivo.
Conclusiones sobre las líneas de investigación estudiadas: Las principales funciones del visual merchandising son: 1) representación del producto en la imaginación del consumidor, de tal forma que convierte la experiencia de compra en una aventura y un descubrimiento continuo; 2) representación del estilo o forma de ser de la marca; 3) mejora de la experiencia de compra 4) presentación de la identidad corporativa, único rasgo que se muestra visible a los públicos; y 5) control de lo que el cliente ve y experimenta en la tienda.
Immediate Effect of Kinesiology Tape on Functionality, Static and Dynamic Balance, Exercise Capacity, and Posture in Users of High-Heeled Shoes
Authors: Huzmeli Irem , Sari Zubeyir , Hallaceli Hasan , Gokcek Ozden , Davut Serkan 
Published: October 2021

Background: Using high-heeled shoes in daily life affects the stability of walking, body posture, and functionality. We aimed to determine the immediate effect of kinesiology taping (KT) on functionality, static and dynamic balance, exercise capacity, and posture in young women using high-heeled shoes.
Methods: Thirty-seven women who wore high-heeled shoes (mean ± SD age, 20.32 ± 1.37 years) were divided into control (n = 20) and study (n = 17) groups. Both limbs of study group participants were taped medially, laterally, and dorsally with KT; no application was made to the control group. Balance (TecnoBody postural line), functionality (vertical jump and functional reach tests), exercise capacity (6-Minute Walk Test), and human body posture (New York Posture Rating Chart) were assessed.
Results: Median use of high-heeled shoes was 8 hours daily, 5 days weekly, and 3 years in the study group versus 6 hours daily, 4 days weekly, and 4 years in the control group. Significance in functional reach distance was found within the control (P = .010) and study (P = .005) groups but not between the groups. Stabilometric monopedal right foot ellipse area (P = .016) and perimeter (P = .009); left foot ellipse area (P = .016), perimeter (P = .023), and front/back standard deviation (P = .018); and dynamic balance area gap percentage (P = .030) were significant within the study group. Posture, vertical jump distance, exercise capacity, stabilometric test results, and bipedal closed-eye and opened-eye results were similar within and between groups (P > .05).
Conclusions: Kinesiology taping has no immediate effect on exercise capacity, vertical jump function, posture, and bipedal static balance but can modulate functional reach function, static monopedal leg balance, and dynamic equilibrium. Further studies are recommended to investigate the additive effect of KT with high-heeled shoes and after 45 min, 24 hours, and 72 hours.
Effectiveness of dentin pre-treatment on bond strength of two self-adhesive resin cements compared to an etch-and-rinse system: an in vitro study
Authors: Hammal Milad , Chlup Zdeněk , Ingr Tomáš , Staněk Ján , Mounajjed Radek 
Published: October 2021

Statement of problem
It has been shown that selective etching improves the bond strength of some self-adhesive resin cements to enamel. The same has yet to be determined with dentin pre-treatment.

Purpose
To evaluate the tensile bond strength of two self-adhesive resin cements after two dentin surface pre-treatments, and also to analyze the cement/dentin interface.

Material and Methods
One hundred and twelve human third molars were extracted. The teeth were distributed into seven groups (n = 16). Maxcem Elite Chroma (MAX) (Kerr, Scafati, Italy) and Relyx U200 (RLX) (3M ESPE, Neuss, Germany) were used without pre-treatment or with two dentin pre-treatments (polyacrylic acid or phosphoric acid). A conventional etch-and-rinse (EAR) luting cement, NX3 Nexus (NX3) (Kerr, Scafati, Italy), was used as an external control group. Before testing, all specimens were stored in distilled water for 24 hours. Three specimens from each group were prepared for scanning electron microscopy observation (SEM). A tensile bond strength test (TBS) was performed for the remaining samples. The data were statistically analyzed using the Kruskal–Wallis test and Pairwise comparisons using the Wilcoxon rank sum test.

Results
MAX without pre-treatment and with phosphoric acid etching attained statistically similar bond strengths to NX3 (P > 0.05). There was a statistical difference (P = 0.00488) between RLX without pre-treatment (5.62 MPa) and NX3 (10.88 MPa). Phosphoric acid pre-treatment increases the bond strength values of RLX to a strength that is comparable to NX3 (P > 0.05). The lowest tensile bond strength (TBS) was attained after the application of polyacrylic acid with MAX (1.98 MPa). No statistical differences were found between the RLX bond strength values after polyacrylic acid treatment and RLX without pre-treatment or NX3 (P > 0.05). SEM observations disclosed an enhanced potential of the self-adhesive cements to infiltrate into dentin tubules and form resin tags when applied after phosphoric acid pre-treatment. The failure mode was dominantly adhesive.

Conclusions
On dentin, the self-adhesive resin cement MAX might be an effective alternative to conventional resin cement. Etching the dentin with phosphoric acid does not have a negative effect on the bond strength of MAX to dentin. On the other hand, phosphoric acid improved the bond strength of RLX when compared to EAR cement.
Functional drug–target–disease network analysis of gene–phenotype connectivity for curcumin in hepatocellular carcinoma
Authors: Zhao Yuanyuan , Tao Jiahao , Chen Zhuangzhong , Li Suihui , Liu Zeyu , Lin Lizhu , Zhai Linzhu 
Published: October 2021

Background
The anti-tumor properties of curcumin have been demonstrated for many types of cancer. However, a systematic functional and biological analysis of its target proteins has yet to be fully documented. The aim of this study was to explore the underlying mechanisms of curcumin and broaden the perspective of targeted therapies.

Methods
Direct protein targets (DPTs) of curcumin were searched in the DrugBank database. Using the STRING database, the interactions between curcumin and DPTs and indirect protein targets (IPTs) weres documented. The protein–protein interaction (PPI) network of curcumin-mediated proteins was visualized using Cytoscape. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was performed for all curcumin-mediated proteins. Furthermore, the cancer targets were searched in the Comparative Toxicogenomics Database (CTD). The overlapping targets were studied using Kaplan–Meier analysis to evaluate cancer survival. Further genomic analysis of overlapping genes was conducted using the cBioPortal database. Lastly, MTT, quantitative polymerase chain reaction (qPCR), and western blot (WB) analysis were used to validate the predicted results on hepatocellular carcinoma (HCC) cells.

Results
A total of five DPTs and 199 IPTs were found. These protein targets were found in 121 molecular pathways analyzed via KEGG enrichment. Based on the anti-tumor properties of curcumin, two pathways were selected, including pathways in cancer (36 genes) and HCC (22 genes). Overlapping with 505 HCC-related gene sets identified in CTD, five genes (TP53, RB1, TGFB1, GSTP1, and GSTM1) were finally identified. High mRNA levels of TP53, RB1, and GSTM1 indicated a prolonged overall survival (OS) in HCC, whereas elevated mRNA levels of TGFB1 were correlated with poor prognosis. The viability of both HepG2 cells and Hep3B cells was significantly reduced by curcumin at concentrations of 20 or 30 μM after 48 or 72 h of culture. At a concentration of 20 μM curcumin cultured for 48 h, the expression of TGFB1 and GSTP1 in Hep3B cells was reduced significantly in qPCR analysis, and reduced TGFB1 protein expression was also found in Hep3B cells.
Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury
Authors: Ke Peng , Qian Lin , Zhou Yi , Feng Liu , Zhang Zhentao , Zheng Chengjie , Chen Mengnan , Huang Xinlei , Wu Xiaodan 
Published: October 2021

Background
Renal ischemia-reperfusion injury (IRI) is a disease with high incidence rate in kidney related surgery. Micro RNA (miRNA) and transcription factors (TFs) are widely involved in the process of renal IRI through regulation of their target genes. However, the regulatory relationships and functional roles of TFs, miRNAs and mRNAs in the progression of renal IRI are insufficiently understood. The present study aimed to clarify the underlying mechanism of regulatory relationships in renal IRI.

Methods
Six gene expression profiles were downloaded from Gene Expression Omnibus (GEO). Differently expressed genes (DEGs) and differently expressed miRNAs (DEMs) were identified through RRA integrated analysis of mRNA datasets (GSE39548, GSE87025, GSE52004, GSE71647, and GSE131288) and miRNA datasets (GSE29495). miRDB and TransmiR v2.0 database were applied to predict target genes of miRNA and TFs, respectively. DEGs were applied for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, followed with construction of protein-protein interaction (PPI) network. Then, the TF-miRNA-mRNA network was constructed. Correlation coefficient and ROC analysis were used to verify regulatory relationship between genes and their diagnostic value in GSE52004. Furthermore, in independent mouse RNA-seq datasets GSE98622, human RNA-seq GSE134386 and in vitro, the expression of hub genes and genes from the network were observed and correlation coefficient and ROC analysis were validated.

Results
A total of 21 DEMs and 187 DEGs were identified in renal IRI group compared to control group. The results of PPI analysis showed 15 hub genes. The TF-miRNA-mRNA regulatory network was constructed and several important pathways were identified and further verified, including Junb-miR-223-Ranbp3l, Cebpb-miR-223-Ranbp3l, Cebpb-miR-21-Ranbp3l and Cebpb-miR-181b-Bsnd. Four regulatory loops were identified, including Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25. The hub genes and genes in the network showed good diagnostic value in mice and human.

Conclusions
In this study, we found 15 hub genes and several TF-miRNA-mRNA pathways, which are helpful for understanding the molecular and regulatory mechanisms in renal IRI. Junb-miR-223-Ranbp3l, Cebpb-miR-223-Ranbp3l, Cebpb-miR-21-Ranbp3l and Cebpb-miR-181b-Bsnd were the most important pathways, while Spp1, Fos, Timp1, Tnc, Fosl2 and Junb were the most important hub genes. Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI.
Light: Revealing the Unseen
Authors: Woodroffe Patrick 
Published: October 2021

AbstractWith four decades of diverse experience illuminating numerous performative events, Patrick Woodroffe, a senior partner of international lighting consultancy Woodroffe Bassett Design, explains the importance of light to performer and scenery. He also gives us an insight into some of his interactions with various performers and then runs us through the sorts of things a typical day entails.
Lonely Together: The Coming Confluence of Virtual and Real
Authors: Neru Ash 
Published: October 2021

AbstractAsh Nehru is a co‐founder of Disguise – a platform that allows creative ideas to combine with software and media server hardware technologies of the sort regularly employed by STUFISH's productions to bring digital video layers into their physical staging designs. Here he examines the use of mixed realities for contemporary performance and their continued potential as new technologies come online.
Curating the Crowd: Social Media and the Choreography of Affective Experience
Authors: Geismar Haidy 
Published: October 2021

AbstractThe advent of social media and the ever more sophisticated functionality of our mobile phones have had a profound effect on the way we view and record events. This is particularly true for large gatherings of people. Haidy Geismar, Professor of Anthropology at University College London, explains how it was once possible to ‘choreograph’ an audience, but nowadays the audience choreographs itself, with thousands of simultaneous viewpoints that are disseminated in multiple, personal yet often public ways.
The Intricate Architecture of Enchantment
Authors: Woroniecki MAciej 
Published: October 2021

AbstractSTUFISH partner MAciej Woroniecki explains some of the parameters that entertainment architects need to consider. They include aspects such as the definition of the brief, the materiality of the proposition, its programmatic appropriateness, its portability and weight and its cost. Above all there must be a clear project narrative that drives the special and spectacular.
Small‐Dipole‐Molecule‐Containing Electrolytes for High‐Voltage Aqueous Rechargeable Batteries
Authors: Huang Zhaodong , Wang Tairan , Li Xinliang , Cui Huilin , Liang Guojin , Yang Qi , Chen Ze , Chen Ao , Guo Ying , Fan Jun , Zhi Chunyi 
Published: October 2021

AbstractHigh‐voltage aqueous rechargeable batteries are promising competitors for next‐generation energy storage systems with safety and high specific energy, but they are limited by the absence of low‐cost aqueous electrolytes with a wide electrochemical stability window (ESW). The decomposition of aqueous electrolytes is mainly facilitated by the hydrogen bond network between water molecules and the water molecules in the solvation sheath. Here, three types of small dipole molecules (small molecules containing a dipole; glycerol (Gly), erythritol (Et), and acrylamide (AM)) are reported to develop aqueous electrolytes with high safety and wide ESW (over 2.5 V) for aqueous lithium‐, sodium‐, and zinc‐ion batteries, respectively. The solvation‐sheath structures are explored by ab initio molecular dynamics (MD) simulations, demonstrating that three types of dipole molecules deplete the water molecules in the solvation sheath of the charge carrier and break the hydrogen bond network between the water molecules, thus effectively expanding the ESW. A battery constructed from lithium titanate and lithium manganate in Gly‐containing electrolyte exhibits an output voltage of 2.45 V and retains a specific capacity of 119.6 mAh g−1 after 400 cycles. This work provides another strategy for exploiting low‐cost high‐voltage electrolytes for aqueous energy‐storage systems.
A Quasi‐Double‐Layer Solid Electrolyte with Adjustable Interphases Enabling High‐Voltage Solid‐State Batteries
Authors: Pan Jun , Zhang Yuchen , Wang Jian , Bai Zhongchao , Cao Ruiguo , Wang Nana , Dou Shixue , Huang Fuqiang 
Published: October 2021

AbstractIncreasing the energy density and long‐term cycling stability of lithium‐ion batteries necessitates the stability of electrolytes under high/low voltage application and stable electrode/electrolyte interfacial contact. However, neither a single polymer nor liquid electrolyte can realize this due to their limited internal energy gap, which cannot avoid lithium‐metal deposition and electrolyte oxidation simultaneously. Herein, a novel type of quasi‐double‐layer composite polymer electrolytes (QDL‐CPEs) is proposed by using plasticizers with high oxidation stability (propylene carbonate) and high reduction stability (diethylene glycol dimethyl ether) in a poly(vinylidene fluoride) (PVDF)‐based electrolyte composites. In‐situ‐polymerized propylene carbonate can function as a cathode electrolyte interface (CEI) film, which can enhance the antioxidant ability. The nucleophilic substitution reaction between diethylene glycol dimethyl ether and PVDF increases the reduction stability of the electrolyte on the anodic side, without the formation of lithium dendrites. The QDL‐CPEs has high ionic conductivity, an enhanced electrochemical reaction window, adjustable electrode/electrolyte interphases, and no additional electrolyte–electrolyte interfacial resistance. Thus, this ingenious design of the QDL‐CPEs improves the cycling performance of a fabricated LiNi0.8Co0.1Mn0.1O2 (NCM811)//QDL‐CPEs//hard carbon full cell at room temperature, paving a new way for designing solid‐state battery systems accessible for practical applications.
When sexual offender treatment in prison‐based social‐therapeutic treatment is not completed: Relationship to risk factors and recidivism after release
Authors: Carl Lena C. , Lösel Friedrich 
Published: October 2021

AbstractBackgroundVarious studies have demonstrated that people who do not complete sex offender treatment have higher recidivism rates than completers or untreated controls. The mechanism behind this association, however, remains unclear. One explanation is that responsivity issues are more prevalent in high‐risk offenders, making treatment failure and recidivism more likely, especially if treatment intensity is insufficient to match criminal needs. In addition, dropout may have a negative effect on offenders by increasing feelings of frustration or self‐doubt.AimsTo retest for a link between treatment discontinuation and recidivism by sex offenders and analyse the mechanisms mediating the link between treatment discontinuation and their recidivism. We hypothesise that non‐completion has a negative effect on recidivism after controlling for a priori differences in risk of recidivism.MethodsWe analysed data from all sex offenders released from Bavarian prisons between 2004 and 2015 who had participated in prison‐based social‐therapeutic treatment and compared non‐completers (n = 100) to offenders ending treatment as planned (n = 428). Criminal risk, offence characteristics, and treatment‐related propensities were measured by a comprehensive assessment instrument, including the Static‐99. Recidivism data were obtained from Federal Official Records with an average time‐at‐risk of 9.43 years (SD = 3.29).ResultsTreatment non‐completion was significantly associated with recidivism after controlling for criminal risk, offence characteristics and treatment duration. This was mainly accounted for by men who had spent at least two years in treatment before premature termination and return to an ordinary prison setting.ConclusionsOur findings aid understanding the potentially negative impact of discontinuing social‐therapeutic treatment for male sex offenders; termination after substantial commitment may be particularly problematic. Future research should encompass large enough sample sizes to study details behind staff or prisoner decisions to return the prisoner to ordinary prison conditions and to mitigate harms by loss of privileges.
Use of Real‐World Data and Evidence in Drug Development of Medicinal Products Centrally Authorized in Europe in 2018–2019
Authors: Eskola Sini Marika , Leufkens Hubertus Gerardus Maria , Bate Andrew , De Bruin Marie Louise , Gardarsdottir Helga 
Published: October 2021

Real‐world data/real‐world evidence (RWD/RWE) are considered to have a great potential to complement, in some cases, replace the evidence generated through randomized controlled trials. By tradition, use of RWD/RWE in the postauthorization phase is well‐known, whereas published evidence of use in the pre‐authorization phase of medicines development is lacking. The primary aim of this study was to identify and quantify the role of potential use of RWD/RWE (RWE signatures) during the pre‐authorization phase, as presented in the initial marketing authorization applications of new medicines centrally evaluated with a positive opinion in 2018–2019 (n = 111) by the European Medicines Agency (EMA). Data for the study was retrieved from the evaluation overviews of the European Public Assessment Reports (EPARs), which reflect the scientific conclusions of the assessment process and are accessible through the EMA website. RWE signatures were extracted into an RWE Data Matrix, including 11 categories divided over 5 stages of the drug development lifecycle. Nearly all EPARs included RWE signatures for the discovery (98.2%) and life‐cycle management (100.0%). Half of them included RWE signatures for the full development phase (48.6%) and for supporting regulatory decisions at the registration (46.8%), whereas over a third (35.1%) included RWE signatures for the early development. RWE signatures were more often seen for orphan and conditionally approved medicines. Oncology, hematology, and anti‐infectives stood out as therapeutic areas with most RWE signatures in their full development phase. The findings bring unprecedented insights about the vast use of RWD/RWE in drug development supporting the regulatory decision making.