bluuebunny/crossref_metadata_2025_split huggingface dataset:
HÁBITOS DE VIDA DE PESSOAS COM DIABETES MELLITUS DURANTE A PANDEMIA DE COVID-19
Authors: Pedroza Giulia Gabriella De Oliveira , Monção Anne Caroline De Moraes , Valladares Heitor De Oliveira , Mello Sávio Dias de Paula , Souza Victor Hugo De Maria Paura de , Silva Júlio Cesar Santos da , Ferreira Marcela Dos Santos 
Published: April 2021

Objetivo: caracterizar impactos do distanciamento social ocasionado pela pandemia da doença do Coronavírus na vida de pessoas com Diabetes Mellitus.Método: estudo descritivo quantitativo, realizado com 102 portadores de Diabetes Mellitus, por meio de formulário virtual, abordando questões sociodemográficas, de autocuidado e de saúde mental, no Brasil no período de maio a junho de 2020. A associação entre as variáveis foi avaliada pelo teste qui-quadrado (p<0,05).Resultados: dos 45 (44,11%) que disseram se alimentar mal, 33 (32,35%) relataram mudanças de peso (p=0,008); com relação à saúde mental, 59 (57,84%) expuseram condições regulares ou ruins; com relação às consultas, 84 indivíduos (82,75%) alegaram interrupção ou irregularidade; dos 58 (56,86%) que declararam prejuízos socioeconômicos, 37 (36,27%) apresentaram dificuldades na adesão de insumos (p<0,000).Conclusão: medidas multiprofissionais devem ser focadas nos fatores que influenciam negativamente o controle metabólico, assim como em estabelecer atendimento a distância, para minimizar a diminuição da atenção assistencial.
APRENDER PRÁTICA BASEADA NA EVIDÊNCIA PELO ENVOLVIMENTO EM ATIVIDADES DE INVESTIGAÇÃO – AUTOPERCEPÇÃO DOS ESTUDANTES
Authors: Cardoso Mário , Baixinho Cristina Lavareda , Ferreira Óscar , Nascimento Patricia , Pedrosa Rita , Gonçalves Paulo 
Published: April 2021

Objetivo: compreender como os estudantes percepcionam o seu envolvimento em atividades de investigação e o contributo para o desenvolvimento de uma prática baseada na evidência.Método: estudo qualitativo, transversal, descritivo e exploratório, realizado em Portugal, em agosto de 2019, que recorreu ao grupo focal, com oito participantes, para responder à questão: “Quais as vantagens da participação dos estudantes de enfermagem em atividades de investigação para o desenvolvimento de conhecimentos, atitudes e competências de utilização da evidência?”. A análise de conteúdo foi realizada com o software NVivo.Resultados: da análise qualitativa dos achados, emergiram cinco categorias e subcategorias: autoaprendizagem, integração teórico-prática, trabalho interdisciplinar, tomada de decisão baseada na evidência e literácia científica.Conclusão: a criação de uma experiência eficaz de aprendizagem ajuda na construção do conhecimento e potencialmente contribui para a saúde da comunidade, os resultados de aprendizagem do estágio e o desenvolvimento de competências essenciais para uma Prática Baseada na Evidência.
Zielona herbata a otyłość – wpływ katechin na metabolizm energetyczny
Authors: Gogga Patrycja , Szałajda Monika , Janczy Agata 
Published: April 2021

Streszczenie
Otyłość jest chorobą metaboliczną, która obecnie zyskała rangę epidemii, stanowiąc jeden z najważniejszych problemów zdrowotnych, społecznych i ekonomicznych na świecie. Nieleczonej otyłości towarzyszy pogorszenie jakości życia oraz występowanie chorób towarzyszących, takich jak cukrzyca czy schorzenia układu sercowo-naczyniowego. W związku z tym poszukuje się nowych metod mających zastosowanie zarówno w profilaktyce otyłości, jak i w obniżaniu nadmiernej masy ciała. Zawarte w zielonej herbacie związki katechinowe, szczególnie galusan epigallokatechiny (EGCG), są jednymi z najintensywniej badanych substancji biologicznie czynnych. Przypisuje się im właściwości przeciwutleniające, przeciwzapalne, przeciwnowotworowe, a także wspomagające regulację masy ciała oraz zawartości tkanki tłuszczowej w organizmie. Liczne badania z udziałem ludzi wykazują, że regularne picie zielonej herbaty jest związane z mniejszą masą ciała, niższym BMI oraz z mniejszym obwodem pasa. Wyniki doświadczeń in vitro oraz na zwierzętach potwierdzają korzystny wpływ katechin na metabolizm energetyczny. Związki te obniżają wchłanianie lipidów i węglowodanów w przewodzie pokarmowym. Wpływają również na metabolizm tych związków, obniżając intensywność lipogenezy i adipogenezy, jednocześnie pobudzając lipolizę i utlenianie kwasów tłuszczowych, a także zwiększając wydatek energetyczny. Udowodniono, że katechiny mają wpływ na wychwyt glukozy przez komórki docelowe pobierające ten cukier poprzez insulinozależny transporter – GLUT4. W artykule omówiono literaturę przedmiotu oraz usystematyzowano zagadnienia związane z rolą katechin obecnych w zielonej herbacie w profilaktyce i wspomaganiu leczenia otyłości.
Replicability of the Questionnaire Assessing the Addition of IN NATURA Vegetable Oil to the Child’s Diet
Authors: Martins Beatriz Araújo Cassane , Lanzillotti Haydée Serrão , Barros Maria Elisa 
Published: April 2021

Objective: To verify the replicability of the questionnaire Assessing the Addition of IN NATURA Vegetable Oil to the Child’s Diet”. Study design: observational cross-sectional study.
Place and Duration of Study: The study was carried out in two pediatric outpatient clinics, one of which refers to a health plan operator (SJM), municipality of São João de Meriti (RJ) and the other, at the Polyclinic Piquet Carneiro of the University from the State of Rio de Janeiro (PPC/UERJ), municipality of Rio de Janeiro (RJ), from March 2017 to January 2019.
Sample: Responsible for children feeding, that is, those who buy the food prepare it or serve meals. SJM, n=150 and PPC/UERJ; n=150.
Methodology: Doornik-Hansen test verified the Multivariate normality of the scores distribution of the items according to Likert scale. Kaiser-Meyer-Olkin was used as a criterion for identify the adequately of sample for the data adjustment. Conbrach's alpha indicated the internal consistency (coherence) between items on each dimension. The reproducibility by reliability was tested by test-retest by using the weighted Kappa coefficient.
Results: Multivariate normality of the SJM scores: (chi2 (22)=602.969 Prob chi2=.0000) and PPC/UERJ: (chi2(22)=411.666 Prob chi2=.0000), adequacy of the samples, KMO: SJM=0.78 to 0.92 and PPC/UERJ=0.76 to 0.92, internal consistency of dimensions (Dimension 1 and 2) by Cronbach's alpha greater than 0.75 for SJM and PPC/UERJ, reproducibility of the questionnaire by weighted Kappa: 0.90 (p value.008), t test for two independent samples, SJM and PPC/UERJ: significant difference for Dimension 1, but not for Dimension 2.
Chlamydia Trachomatis Infection as a Risk Factor of Infertility in Women
Authors: Sharaf Mohamed A. , El-Bohoty Shereen B. , Hodeib Hossam A. , El-Kholi Dina G. 
Published: April 2021

Background: C. trachomatis is known to cause damage to the female reproductive tract, primarily due to adhesions or obstructions of the fallopian tubes secondary to the inflammatory response. Tubal Factor of Infertility (TFI) is the main cause of infertility in 10-30% of cases in developed countries and C. trachomatis is the most common causative agent to TFI in the developed world. The aim of this study was to investigate the possible role of the chlamydial serology as a screening test for tubal infertility, by the detection of the anti-chlamydial IgG antibodies by using E.L.I.S.A. and study the benefit of using non-invasive methods to diagnose chlamydial infection.
Materials and Methods: This prospective randomized clinical study was conducted on a (50) women complaining of Infertility due to Tubal Factor. The patient was randomly classified into two groups: (50)Group I: complaining primary or secondary infertility. Group II: including (25) patients pregnant and came for Antenatal care
Results: Prevalence of different types of tubal factor in the study population was 12% in Distal block (DB), 10% Distal block plus peritubal adhesions (DB + PTA), 40% Hydrosalpinx (HS), 8% Hydrosalpinx plus peritubal adhesions (HS + PTA), 26% Proximal block (PB), 4% Peritubal adhesions (PTA). serum antichlamydial IgG level was significantly higher among group I (8.62 ±1.4) than group II (2.11±0.82). Also, 46% of group I had serum antichlamydial IgG positive vs. (12%) in group II with significant difference. Comparing positive C. trachomatis IgG with type of infertility, a total of 13 (57.7%) of those with primary infertility and 10 (42.3%) of those with secondary infertility tested positive. The difference was of no statistical significance (P=0.725). Conclusion: We can conclude that, Chlamydia trachomatis is a major factor in female infertility especially for tubal factor of infertility, serum Chlamydia trachomatis IgG assay could be used a predictive factor for tubal factor infertility.
Preparative Chromatography for Production
Authors: Dapremont Olivier 
Published: April 2021

Abstract
The article introduces the reader to preparative chromatography as a purification tool for the manufacturing of active pharmaceutical ingredients (APIs). In a first part, the history of the development of chromatography as a separation technique is reviewed and concepts associated with the process development and its modeling are introduced. In a second section, the various techniques used to optimize a preparative separation for production are reviewed. Aspects of the various phases of the process development from early clinical phase up to commercial manufacturing are discussed with emphasis on intellectual property, solvent considerations, and separation robustness. Scale‐up rules are also introduced at the end of the section. Finally, the author discusses the implementation of a chromatographic step at commercial scale; handling of the chromatographic packing material and plant operations are more specifically highlighted.
Intracellular Bottom‐up Synthesis of Ultrasmall CuS Nanodots in Cancer Cells for Simultaneous Photothermal Therapy and COX‐2 Inactivation
Authors: Feng Liandong , Wu Shanshan , Wu Yuzhou 
Published: April 2021

AbstractThe clinical application of photothermal therapy (PTT) is limited by the accuracy of thermal damage and the risk of tumor metastasis and relapse induced by hyperthermia‐related inflammation. Intracellular bottom‐up synthesis (iBuS) of CuS nanoparticles from small‐molecule precursors inside tumor cells triggered by tumor specific stimuli is a promising strategy to enhance the precision of PTT treatment and reduce the risk of nondegradable metal nanoparticles. Herein, monolocking nanoparticles (MLNPs) with Cu‐meloxicam complexes encapsulated by human serum albumin (HSA) are reported, which efficiently form CuS nanodots via the elevated concentration of endogenous H2S inside tumor cells and meanwhile release meloxicam for anti‐inflammatory effects. The intracellular bottom‐up fabrication of CuS nanodots is directly visualized by TEM. An enhanced PTT effect is observed with 4T1 cells caused by additional meloxicam‐induced inactivation of the COX‐2 enzyme. After systemic administration, MLNPs completely ablate tumors under laser exposure, simultaneously inhibiting the inflammation induced by photothermal damage, and can be cleared via the kidney into urine. This strategy provides a new route for activated multimodal therapy, which could be applicable to precisely combat cancer.
Tailoring the Interface in FAPbI3 Planar Perovskite Solar Cells by Imidazole‐Graphene‐Quantum‐Dots
Authors: Gao Zhi‐Wen , Wang Yong , Liu Hui , Sun Jiayun , Kim Jinwook , Li Yan , Xu Baomin , Choy Wallace C. H. 
Published: April 2021

AbstractOrganic–inorganic hybrid perovskites have reached an unprecedented high efficiency in photovoltaic applications, which makes the commercialization of perovskite solar cells (PSCs) possible. In the past several years, particular attention has been paid to the stability of PSC devices, which is a critical issue for becoming a practical photovoltaic technology. In particular, the interface‐induced degradation of perovskites should be the dominant factor causing poor stability. Here, imidazole bromide functionalized graphene quantum dots (I‐GQDs) are demonstrated to regulate the interface between the electron transport layer (ETL) and formamidinium lead iodide (FAPbI3) perovskite layer. The incorporation of I‐GQDs not only reduces the interface defects for achieving a better energy level alignment between ETL and perovskite, but also improves the film quality of FAPbI3 perovskite including enlarged grain size, lower trap density, and a longer carrier lifetime. Consequently, the planar FAPbI3 PSCs with I‐GQDs regulation achieve a high efficiency of 22.37% with enhanced long‐term stability.
High power density and flexible self‐powered piezoelectric nanogenerator based on solution crystallization
Authors: Lan Jiongfang , Zheng Lin , An Zhiqiang , Hou Deshan , Sun Dongpeng , Zhu Jiliang 
Published: April 2021

AbstractA flexible self‐powered piezoelectric nanogenerator (FSPN) of high power density was constructed using a poly (vinylidene fluoride) (PVDF) polymer matrix based on solution crystallization. Since the solubility parameter of the N‐methylpyrrolidone (NMP) was closed to that of the PVDF, the FSPNs fabricated by PVDF and NMP showed a high concentrations of β‐phase and a high power density of 6.6 W/m3 together with excellent mechanical properties and transparent. In addition, the FSPN retained its excellent performance even after 2000 cycles of cantilever vibration, which hold a great potential for harvesting mechanical energy for self‐powered systems and provide a simpler solution for energy collection and utilization in our actual lives.
Experimental design to evaluate properties of electrospun fibers of zein/poly (ethylene oxide) for biomaterial applications
Authors: Medeiros Gabriela Brunosi , de Souza Paulo Ricardo , Retamiro Karina Miyuki , Nakamura Celso Vataru , Muniz Edvani Curti , Corradini Elisângela 
Published: April 2021

AbstractThe production of polymer fibers from the combination of zein and PEO might have great potential in the field of biomaterial. Zein/PEO fibers were obtained in this work through solution electrospinning. An experimental design, 24‐1, was used for evaluating the influences of PEO content in the blend, distance from the needle tip to the collector, applied electric voltage and solution flow for average fiber diameter and relative‐yield process. Beyond this, the relationship between PEO content in the blend and the fiber properties were evaluated through FTIR, DSC, TG, tensile tests, and cytotoxic tests. The factor that exerts the greatest effect on the average fiber diameter response was the electrical voltage. The increase in PEO content in the blend decreased the thermal stability and increased the degree of the fibers' crystallinity. The mechanical tests showed that fibers with higher elongation were obtained at richer PEO blends. The fibers presented cytocompatible characteristics.
Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics
Authors: Michniewicz Filip , Saletta Federica , Rouaen Jourdin R. C. , Hewavisenti Rehana V. , Mercatelli Daniele , Cirillo Giuseppe , Giorgi Federico M. , Trahair Toby , Ziegler David , Vittorio Orazio 
Published: April 2021

AbstractCopper is an essential transition metal frequently increased in cancer known to strongly influence essential cellular processes. Targeted therapy protocols utilizing both novel and repurposed drug agents initially demonstrate strong efficacy, before failing in advanced cancers as drug resistance develops and relapse occurs. Overcoming this limitation involves the development of strategies and protocols aimed at a wider targeting of the underlying molecular changes. Receptor Tyrosine Kinase signaling pathways, epigenetic mechanisms and cell metabolism are among the most common therapeutic targets, with molecular investigations increasingly demonstrating the strong influence each mechanism exerts on the others. Interestingly, all these mechanisms can be influenced by intracellular copper. We propose that copper chelating agents, already in clinical trial for multiple cancers, may simultaneously target these mechanisms across a wide variety of cancers, serving as an excellent candidate for targeted combination therapy. This review summarizes the known links between these mechanisms, copper, and copper chelation therapy.
Multispecies integrated population model reveals bottom‐up dynamics in a seabird predator–prey system
Authors: Quéroué Maud , Barbraud Christophe , Barraquand Frédéric , Turek Daniel , Delord Karine , Pacoureau Nathan , Gimenez Olivier 
Published: April 2021

AbstractAssessing the effects of climate and interspecific relationships on communities is challenging because of the complex interplay between species population dynamics, their interactions, and the need to integrate information across several biological levels (individuals, populations, communities). Usually used to quantify single‐species demography, integrated population models (IPMs) have recently been extended to communities. These models allow fitting multispecies matrix models to data from multiple sources while simultaneously accounting for uncertainty in each data source. We used multispecies IPMs accommodating climatic variables to quantify the relative contribution of climate vs. interspecific interactions on demographic parameters, such as survival and breeding success, in the dynamics of a predator–prey system. We considered a stage‐structured predator–prey system combining 22 yr of capture–recapture data and population counts of two seabirds, the Brown Skua (Catharacta lönnbergi) and its main prey the Blue Petrel (Halobaena caerulea), both breeding on the Kerguelen Islands in the Southern Ocean. Our results showed that climate and predator–prey interactions drive the demography of skuas and petrels in different ways. The breeding success of skuas appeared to be largely driven by the number of petrels and to a lesser extent by intraspecific density dependence. In contrast, there was no evidence of predation effects on the demographic parameters of petrels, which were affected by oceanographic factors. We conclude that bottom‐up mechanisms are the main drivers of this skua–petrel system.
Competition for food reduces disease susceptibility in a marine invertebrate
Authors: Pernet Fabrice , Lugué Klervi , Petton Bruno 
Published: April 2021

AbstractCompetition between organisms interfere in host and pathogen dynamics in ways that are difficult to predict. By one side, competitors can reduce the food supply and cause nutritional stress. Such stress could further modulate the susceptibility to infection by altering immune response or metabolic rate of the host. Alternatively, competitors may trap pathogens before they reach the focal host, and therefore reduce, enhance, or have no effect on infection according to the competitor's susceptibility to the infection. To better understand how competition influences host and pathogen interactions, we experimentally assessed the relative importance of competition for pathogens and resources on the severity of a viral disease infecting the Pacific oysterCrassostrea gigas. We designed an open‐flow system where food enriched seawater flowed to filter‐feeding competitors (or empty controls) before being delivered to recipient oysters. We tested a range of competing species that exhibit both low (ascidians, European oysters, mussels) and high (Pacific oysters) susceptibility to the virus. We assessed the physiological condition of the recipient oysters during acclimation, we added virus‐contaminated seawater upstream of the distribution system, and we monitored host and pathogen dynamics. We found that the presence of competitors, regardless of susceptibility to the virus, indirectly reduced the infection rate of hosts by decreasing their food ingestion and growth rates. Although competitors can reduce viral particles from the seawater, this had no effect on the host population. Our data suggest that the effect of competition for food overwhelmed that of competition for pathogens, thus emphasizing the importance of considering resource availability in host and pathogen dynamics. More particularly, resource availability can have positive effects at the individual level, fostering physiological condition and growth, but negative effects at the population level, increasing magnitude of epidemics.
Effects of timber harvest on survival and movement of stream salamanders in a managed forest landscape
Authors: Halloran Kelly M. , Guzy Jacquelyn C. , Homyack Jessica A. , Willson John D. 
Published: April 2021

AbstractWith escalating anthropogenic alteration of landscapes worldwide, managed forests are increasingly important as providers of ecosystem services and wildlife habitat. Therefore, it is crucial to maintain a balance between producing forest products and biodiversity conservation. Several studies have reported negative effects of forest management on terrestrial plethodontid salamanders, but fewer have focused on stream‐dwelling species or evaluated mechanisms for shifts in their abundance (e.g., mortality vs. movement). We used a before–after–control–impact design to examine the effects of clear‐cut harvesting on a semi‐aquatic stream‐breeding salamander endemic to the Ouachita Mountains,Desmognathus brimleyorum. We conducted a three‐year capture–mark–recapture (CMR) study at three streams within a managed pine (Pinusspp.) landscape in west‐central Arkansas, USA. Loblolly pine (Pinus taeda) stands surrounding two of the streams were clear‐cut (leaving a 14–21 m wide forested buffer on each side of the stream) midway through the study; the third stream served as a control site and remained unharvested. We estimated apparent survival using open CMR models and compared salamander movement over time and between harvested and control streams. Overall, our models revealed seasonal and temporal variation in salamander survival and abundance, but little evidence for strong immediate effects of timber harvesting on post‐metamorphic salamanders within two years postharvest. However, there was increased salamander movement at sites where forest harvest occurred. Our results suggest that streamside buffers of at least 14–28 m on either side of a stream are effective for minimizing immediate effects of forestry activities on juvenile and adult stream‐dwelling salamanders, when timber harvest occurs in the winter months. These results will inform management decisions aimed at conserving biodiversity and ecosystem integrity in managed forest landscapes while also filling a critical gap in the knowledge of stream salamander demographic parameters.