bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trabeculectomy With Intraoperative 5-Fluorouracil
Authors: Sidoti Paul A , Choi James C , Morinelli Elisa N , Lee Paul P , Baerveldt George , Minckler Don S , Heuer Dale K 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To investigate the outcome and complication rates of trabeculectomy following the combined use of intraoperative, topical 5-fluorouracil (5-FU) and low-dose, postoperative subconjunctival 5-FU injections.
* PATIENTS AND METHODS: Forty-one eyes of 41 patients with advanced, medically uncontrolled glaucoma underwent trabeculectomy with intraoperative episcleral application of 5-FU (50 mg/ml for 5 minutes). A variable number of subconjunctival 5-FU injections were administered postoperatively at the discretion of the operating surgeon.
* RESULTS: Six-, 12-, and 15-month life-table success rates (5 mm Hg ≤ intraocular pressure [IOP ≤ 21 mm Hg) were 100%, 97%, and 83%, respectively. Mean postoperative IOP was 12.1 ± 4.3 mm Hg. An average of 2.2 ± 1.6 (range 0 to 7) supplemental subconjunctival 5-FU injections were administered postoperatively. Corneal epithelial erosions developed in 7 (17%) of the eyes. Five of 7 patients who underwent subsequent surgical procedures maintained successful control of IOP at an average of 11.0 ± 4.8 (range 5 to 16) months after the secondary surgery.
* CONCLUSION: Trabeculectomy with intraoperative 5-FU is effective in controlling IOP while possibly minimizing the need for frequent postoperative injections and the occurrence of corneal epitheliopathy.
[Ophthalmic Surg Lasers 1998;29:552-561.]
Phacotrabeculectomy With "Smile" Incision, Punch, and Single Releasable Suture
Authors: Manners Timothy D 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To describe and prospectively evaluate a technique of phacotrabeculectomy consisting of a "smile" wound, corneal punch, and tight closure of the scleral flap with a single releasable suture.
* PATIENTS AND METHODS: A cohort of 25 patients underwent this procedure performed by a single surgeon. The surgical technique is described and the first year of follow-up is evaluated.
* RESULTS: Mean intraocular pressure (IOP) was 25.4 mm Hg preoperatively and 16.2 mm Hg at a mean follow-up of 10.2 months (a fall of 36%). Incidence of immediate postoperative complications was low, especially those related to hypotony (wound leak, shallow anterior chamber, fibrinous uveitis). There was a 50% incidence of postoperative IOP spikes of greater than 26 mm Hg. Three cases were deemed partial failures at 1 year (IOP < 21 mm Hg on medical treatment), and three cases were complete failures (IOP > 21 mm Hg or further surgery required).
* CONCLUSION: The tight scleral flap and routine release of the releasable suture on the third postoperative day reduce immediate postoperative complications compared with other studies, with the exception of IOP spikes. The lack of aqueous flow in the immediate postoperative phase may be a factor in the failure rate, which is higher than expected.
[Ophthalmic Surg Lasers 1998;29:570-574.]
Inhibition of Migrating Lens Epithelial Cells at the Capsular Bend Created by the Rectangular Optic Edge of a Posterior Chamber Intraocular Lens
Authors: Nishi Okihiro , Nishi Kayo , Sakanishi Kohtaro 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To study the mechanism of the reportedly low incidence of posterior capsule opacification (PCO) in eyes treated with a posterior chamber intraocular lens (PC IOL).
* MATERIALS AND METHODS: Various IOL designs, including the PC IOL, were studied using scanning electron microscopy. Rabbit lens capsules were studied histopathologically 2, 3, and 4 weeks after implantation of a PC IOL in one eye and a biconvex polymethylmethacrylate (PMMA) IOL in the contralateral eye as a control.
* RESULTS: The optic edge of the PC IOL was sharp and rectangular, whereas that of the biconvex PMMA or silicone IOLs from various manufacturers had been smoothed and rounded by polishing. PCO was significantly reduced in the eye with a PC IOL in all rabbits. The lens capsule wrapped tightly around the optic edge of the PC IOL so that it conformed to the same shape and thereby created a distinct rectangular bend in the capsule or a rectangle between the optic edge and the posterior capsule. Migrating lens epithelial cells (LECs) were obviously inhibited at that site.
* CONCLUSIONS: A discontinuous capsular bend or rectangle created by the sharp, square optic edge of the PC IOL may have induced contact inhibition to migrating LECs and reduced PCO. How, whether, and to what extent this design-dependent effect is influenced by features of the IOL material needs to be clarified by comparison with results achieved with an IOL made from the same material in a different design and vice versa.
[Ophthalmic Surg Lasers 1998;29:587-594.]
The Effects of Topical Steroids on Refractive Outcome and Corneal Haze, Thickness, and Curvature After Photorefractive Keratectomy With a 6.0-mm Ablation Diameter
Authors: Aras Cengiz , Özdamar Akif , Aktunç Rengin , Erçikan Celal 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To study the effect of topical prednisolone acetate after photorefractive keratectomy (PRK) using a 6.0-mm ablation diameter on the refractive and visual outcomes, corneal haze, corneal thickness, and corneal curvature in a prospective, double-masked, randomized manner.

* PATIENTS AND METHODS: Seventy-two eyes of 36 patients who had excimer laser PRK for correction of myopia ranging from -3.00 to -6.00 D (-4.11 ± 0.84 D in eyes treated with steroids and -4.38 ± 0.79 D in eyes treated with placebo; mean ± SD) were enrolled. PRK procedures were performed using a 193-nm argo n-fluo ride excimer laser with 180-mj/cm
p 2
fluence, a 10-Hz repetition rate, and a 6.0-mm ablation diameter. One eye of each patient was treated with the steroid (prednisolone acetate) and the other eye with placebo. Patients were observed for at least 12 months after PRK.

* RESULTS: There was no statistically significant difference between the steroid and the placebo groups with regard to refraction measurements that were taken postoperatively at 3 months (P = .39) and 12 months (P = .51). The corneas showed an increase in thickness after PRK in both groups, but the difference was not statistically significant at 12 months postoperatively (P = .45). The corneal haze score was not statistically different at any stage between groups (P = .30 at 3 months, P = .84 at 12 months). Keratometric data derived from corneal topography did not show any statistically significant difference (P = .85 at 3 months, P = .96 at 12 months). The rate of uncorrected visual acuity of 20/40 or more was 79.4% (27 eyes) in the steroid group and 70.5% (24 eyes) in the placebo group (P = .40). The rate of loss of 2 or more lines in best spectacle-corrected visual acuity was 5.85% (2 eyes) in the steroid group and 8.8% (3 eyes) in the placebo group (P = 1.0).
* CONCLUSION: Topical prednisolone acetate use for 3 months after PRK with a 6.0-mm ablation diameter has no effect on refractive and visual outcome, corneal haze, corneal thickness, and corneal curvature.
[Ophthalmic Surg Lasers 1998;29:621-627.]
Synthetic Meshwork Implant for Glaucoma Filtering Surgery: Effect of Adjunct Heparin and Sodium Hyaluronate in Rabbits
Authors: Kondo Hiroyuki , Fantes Francisco , Kato Hirohiko , Gautier Sandrine , Parel Jean-Marie 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To evaluate the efficacy of a novel filtering implant, a synthetic meshwork (MESH), with or without heparin or sodium hyaluronate amendment.
* MATERIALS AND METHODS: Eighteen eyes of 18 rabbits received MESH surgery. The eyes were divided into three subgroups. Six eyes received the MESH implant with no modification (group 1), 6 eyes received MESH saturated with heparin (group 2), and 6 eyes received MESH with sodium hyaluronate administration into the anterior chamber during surgery (group 3). Intraocular pressure (IOP) and outflow facility were measured during a period of 6 months.
* RESULTS: The MESH-implanted eyes showed lower IOP and higher outflow facility than control eyes up to postoperative days 119 and 49, respectively (P > .05). Earliest functional failure was seen in group 3 and latest in group 2.
* CONCLUSION: MESH implant surgery showed a long-term efficacy in reducing IOP. The beneficial effects of added heparin were limited. Sodium hyaluronate administration reduced the efficacy of the implant device.
[Ophthaimic Surg Lasers 1998;29:669-676.]
Ellipsoidal Fitting of Corneal Topography Data After Arcuate Keratotomies With Compression Sutures
Authors: Langenbucher Achim , Seitz Berthold , Kus Murat M , Vilchis Ernesto , Küchle Michael 
Published: April 2021

* BACKGROUND AND OBJECTIVE: After paired arcuate keratotomies and compression sutures (AK) for treatment of high postkeratoplasty astigmatism, corneal topography tends to be irregular. The purpose of this study was to demonstrate a mathematical method for approximation of discrete corneal topography power data with an ellipsoid for better appreciation of the clinical outcome after AK.
* PATIENTS AND METHODS: Thirty-one eyes of 28 consecutive patients who underwent AK for excessive postkeratoplasty astigmatism were studied. Regular keratometry, corneal topography (TMS-1), subjective refraction, and best-corrected visual acuity (VA) were assessed preoperatively and at 1 week and 1 year postoperatively. A simplex algorithm was applied for fitting an ellipsoidal surface to raw corneal topography power data. A set of parameters (meridional power, axis, and asphericity) were calculated. The cylinder of subjective refraction was correlated with the keratometric readings, the simulated keratometry (SimK) of the topography system, and the respective parameters of the model surface.
* RESULTS: Keratometric astigmatism and the cylinder of the model surface decreased from 8.1 ± 3.2 and 7.9 ± 2.9 D preoperatively to 4.5 ±2.1 and 5.3 ± 2.0 D after 1 year, respectively. The asphericity in both meridional cross sections changed from a prolate ellipse preoperatively to an ablate ellipse at the early postoperative follow-up stage. Regarding the cylinder axis, there was a significant correlation of the model surface with the refractive cylinder at all examinations (P < .05), whereas there was no significant correlation of the SimK axis and the refractive cylinder axis.
* CONCLUSION: The approximation of corneal topography power data with an ellipsoidal model surface renders reconstruction of clinically relevant corneal topography parameters, including corneal asphericity with a marked data compression. Even in markedly irregular corneal surfaces, such as after AK, the correlation of amount/axis of refractive cylinder with the model surface parameters is more accurate than it is with respective SimK values of corneal topography analysis.
[Ophthalmic Surg Lasers 1998;29:738-748.]
The Treatment of Lacrimal Apparatus Obstruction With the Use of an Inner Canthal Jones Tube Insertion via a Transcaruncular Route
Authors: Lee Jong Soo , Jung Geun , Lee Ji Eun , Oum Boo Sup , Lee Sang Hyup , Rho Hwan Jung 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To evaluate the clinical utility of the lacrimal bypass surgery using Bowman's probe in treatment of obstruction of the lacrimal apparatus.
* PATIENTS AND METHODS: This study evaluated 124 cases of obstruction of the lacrimal passage systems with mean epiphora of 2.7 years. An incision was made on the side of the caruncle, and the lacrimal bone was penetrated between the lacrimal sac and the nasal mucosa by Bowman #0. Insertion of a Jones tube was made at the new lacrimal pathway, a puctum dilator or scissors was introduced through the caruncle and dilated across the lacrimal bone into the nasal cavity. The Jones tube was introduced over the probe into the nasal cavity, and fixed at the caruncle with nonabsorbable suture material.
* RESULTS: Complete resolution of epiphora was accomplished in 120 (96.8%) of 124 eyes; only 4 (3.2%) eyes failed during a mean of 17.1 months of follow-up.
* CONCLUSION: This procedure is simple and safe with no facial scarring, short operation time, high success rate, and can be performed under local anesthesia. Therefore, the clinical utility of this procedure seems to be of value in treatment of complicated obstruction of the lacrimal apparatus.
[Ophthalmic Surg Lasers 2001;32:48-54]
Sclerotomy Using Needle Puncture and Subconjunctival Injection of Mitomycin C
Authors: Wygnanski-Jaffe Tamara , Belkin Michael , Rosner Mordechi , Yoseph Glovinsky 
Published: April 2021

* OBJECTIVE: To explore the possibilty of creating a temporary sclerotomy using a 26-gauge needle and sustaining its patency by injectiong 0.1 mL of 0.1 mg/mL of mitomycin C (MMC)
* ANIMALS AND METHODS: Twenty-four New Zealand white rabbits were randomized into 3 groups. In the test group, puncture was performed using 26gauge needle penetrating the anterior chamber at the limbus, and 0.1 mg/mL MMC were injected subconjunctivally. In the control group, a puncture was performed in the same fashion and in the MMC group, MMC only was injected subconjunctivally. Intraocular pressure (IOP) was measured prior to surgery and at days 1, 3, 7, 10, 14, 21, and 28.
* RESULTS: The mean intraocular pressure in eyes that underwent puncture with application of MMC was significantly lower than the IOP in the eye at all measurements up to and including day 21. In the puncture group, pressure was significantly lower than in the fellow eye only at day 3. No significant pressure reduction was observed at any measurement interval in eyes treated with MMC only.
* CONCLUSION: This simple technique of subconjunctival puncture of the limbus combined with application of MMC was effective in lowering IOP in rabbits. This may serve to attain a temporary filter in patients who need strict short-term pressure control.
[Ophthalmic Surg Lasers 2001;32:140-144]
The Association of Unilateral Congenital Glaucoma and Congenital Lower Lid Entropion: Causal or Casual?
Authors: Mandal Anil K , Honavar Santosh G , Gothwal Vijaya K 
Published: April 2021

Abstract. This case documents unilateral congenital glaucoma associated with congenital lower lid entropion. A 2-year-old female infant was referred for evaluation and treatment of right-side buphthalmos caused by congenital glaucoma associated with bilateral congenital lower lid entropion that was prominent on the right side and present at birth. Examination disclosed a lower eyelid entropion of the right side that was treated surgically by reinserting the disinserted retractor aponeurosis to anterior inferior tarsal border. After three weeks, the patient was successfully treated with primary combined trabeculotomy-trabeculectomy for congenital glaucoma. The entropion of the left lower lid was asymptomatic and did not require any surgery. Buphthalmos caused by congenital glaucoma may be associated with congenital lower lid entropion and the association may be causal or coincidental.
[Ophthalmic Surg Lasers 2001;32:149-151]
Retrocorneal Membrane After Penetrating Keratoplasty
Authors: Lifshitz Tova , Oshry Tzafrir , Rosenthal Gideon 
Published: April 2021

Abstract. Retrocorneal membranes after penetrating keratoplasty (PKP) is a well known complications, resulting from unintentional retention of the host Descemet's membrane (DM), or donor DM detachment. We describe for the first time the formation of a retrocorneal inflammatory membrane that mimics donor DM detachment or retained recipient DM, and discuss the differential diagnosis of a retrocorneal membrane after PKP. Two patients who underwent PKP and subsequently developed a retrocorneal membrane are described. In both patients' eyes a retrocorneal membrane was observed immediately following penetrating keratoplasty. While the first patient's membrane persisted for 33 months in the presence of a clear graft, the second patient's membrane disintegrated and dissolved within two weeks following treatment with topical steroids. The first case describes a patient with retained Descemet's membrane, while in the second case, it turned out that the retrocorneal membrane was actually an inflammatory membrane.
[Opthalmic Surg Lasers 2001;32:159-161]
Risk Factors in Endophthalmitis Leading to Evisceration or Enucleation
Authors: Tsai Yi-Yu , Tseng Sung-Huei 
Published: April 2021

* BACKGROUND AND OBJECTIVE: This study aimed to evaluate the risk factors associated with evisceration or enucleation in endophthalmitis cases.
* PATIENTS AND METHODS: A retrospective analysis was conducted of all cases of endophthalmitis in a single unit over a 10-year period. The cases were divided into two groups. The group 1 consisted of patients with endophthalmitis who underwent evisceration or enucleation. The group 2 included patients with endophthalmitis who recovered with intravitreal injection or vitrectomy.
* RESULTS: During the 10-year study period, 86 patients with endophthalmitis were admitted for treatment. Evisceration or enucleation was undergone by 20 patients (23.2%) (Group 1); Group 2 consisted of 66 patients. Older age (P= 0.03), no light perception at presentation (P < 0.0001), endophthalmitis associated with corneal ulcer (P < 0.0001), and endogenous endophthalmitis (P = 0.048) were statistically significant factors associated with the need for evisceration or enucleation.
[Ophthalmic Surg Lasers 2001;32:208-212]
Postoperative Complications and Visual Results in Uniocular Pediatric Traumatic Cataract
Authors: Brar Gagandeep S , Ram Jagat , Pandav Suriner S , Reddy Ganjikunta S , Singh Usha , Gupta Amod 
Published: April 2021

* BACKGROUND AND OBJECTIVES: This study was prospectively carried out to evaluate the postoperative complications and visual results following posterior chamber intraocular lens (PCIOL) implantation in children with unilateral traumatic cataract.
* PATIENTS AND METHODS: We prospectively evaluated 40 children, 12 years or younger, with traumatic cataract (blunt trauma, n = 22 eyes, repaired penetrating eye injury, n = 18 eyes) undergoing PCIOL implantation with a minimum follow-up period of one year. Children with posterior segment ocular injury were excluded.
* RESULTS: The postoperative complications were significantly higher in the penetrating eye injury group as compared to blunt trauma group (ie, pupillary capture 44.44% vs 9.09%, posterior capsulotomy rate 83.33% vs 40.90% and IOL decentration 27.77% vs 4.54%). The final visual acuity was 6/12 or better in 38.8% and 86.36% of eyes with penetrating eye injury and blunt trauma, respectively.
* CONCLUSION: Extracapsular cataract extraction (ECCE) with PCIOL implantation in traumatic cataract following blunt trauma results in better visual outcome and fewer complications compared to penetrating eye injury if the posterior segment is not involved.
[Ophthalmic Surg Lasers 2001;32:233-238]
Structural Changes of the Retina in Retinal Vein Occlusion-Imaging and Quantification With Optical Coherence Tomography
Authors: Lerche Ralf-Christian , Schaudig Ulrich , Scholz Frank , Walter Andreas , Richard Gisbert 
Published: April 2021

* BACKGROUND AND OBJECTIVE: To evaluate the potential oí optical coherence tomography (OCT) for imaging and quantifying structural changes in the retinal architecture following venous occlusive disease.
* PATIENTS AND METHODS: We studied 20 patients with retinal venous occlusive disease: 5 patients suffered from branch retinal vein occlusion (BRVO), and 15 from central retinal vein occlusion (CRVO). Patients with CRVO were studied within 72 hours after the first onset of symptoms. Patients were examined by OCT after a complete ophthalmologic examination including fluorescein angiography. A standard set of linear scans through the center of fixation and individual scans over areas of special interest were performed. Scans were qualitatively evaluated and quantitative measurements were performed on single A-scans at 5 locations of linear scans. Measurements were taken in the center of fixation, at the foveal rim, and at the edge of the scan. We measured total retinal thickness, thickness of cystoid spaces, and thickness of the highly reflective outer band.
* RESULTS: OCT produced detailed images of retinal thickening, intra- and subretinal hemorrhage, intra- and subretinal fluid accumulation, and formation of intraretinal cystoid spaces. Quantitative evaluation revealed a mean central retinal thickness of 274 ±181 urn (72-760 urn) in patients with central retinal vein occlusion. Visual acuity did not correlate with central or extrafoveal retinal thickness.
* CONCLUSION: Optical coherence tomography is a useful imaging technique for studying changes of retinal architecture following venous occlusive disease. Even minor changes like localized subretinal fluid accumulation or beginning epiretinal membrane formation can be visualized in detail. In contrast to other diseases like diabetic maculopathy, quantitative assessment of macular thickness does not correlate to visual acuity. Nevertheless, because of detailed imaging, OCT might become a useful tool in the follow-up and treatment of individual patients.
[Ophthalmic Surg Lasers 2001;32:272-280]
Suramin to Enhance Glaucoma Filtering Procedures: A Clinical Comparison With Mitomycin
Authors: Mietz Holger , Krieglstein Günter K 
Published: April 2021

* BACKGROUND AND OBJECTIVE: Trabeculectomies performed with mitomycin are more likely to be successful, but have an increased rate of complications. We performed a novel approach to enhance the outcome of trabeculectomies using suramin, a substance that inhibits the action of growth factors.
* MATERIALS AND METHODS: Trabeculectomies were performed in 10 eyes of 10 patients with advanced stages of complicated glaucoma and/or poor visual prognosis in a prospective, consecutive study. For comparison, an equal number of matched controls were selected from surgical cases using mitomycin and another 20 cases without mitomycin. Pre- and post-operative data were evaluated as well as complications and the need for further surgeries.
* RESULTS: The follow up was 18 months for the eyes in all groups. Average IOP values decreased from 32.7 mm Hg and 29.5 mm Hg to 19.7 mm Hg and 19.3 mm Hg in the suramin and mitomycin groups. The average number of medications decreased from 2.6 and 2.5 (P <0.86, t-test) to 1.3 and 0.4 (P <0.027) in the suramin- and mitomycin-treated eyes at the last visit. Hypotony following trabeculectomy occurred in 2/10 cases in suramin-treated eyes and 5/10 cases in mitomycin-treated eyes (P <0.18). Hypotony lasting for more than three months occurred in 0/10 suramin-treated eyes and 5/10 mitomycin-treated eyes. Conjunctival dehiscence (2/10), choroidal detachment (4/10), hypotony maculopathy (1/10), and endophthalmitis (1/10) were only noted in mitomycin-treated eyes. Without mitomycin 60% of surgeries performed failed.
* CONCLUSIONS: In this first study using suramin to inhibit fibrosis following trabeculectomy for complicated cases of glaucoma, it appears that the use of suramin is associated with fewer cases of severe hypotony, choroidal detachment, and severe visual loss as compared to mitomycin, while the success rates seem to be similar.
[Ophthalmic Surg Lasers 2001;32:358-369]