bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-fraction Stereotactic Radiosurgery for Atypical Meningiomas (WHO grade II): Treatment Results Based on a 25-year Experience
Authors: Hasegawa Hirotaka , Vakharia Kunal , Michael Link J , Stafford Scott L , Brown Paul D , Parney Ian F , Burns Terry C , Yan Elizabeth S , Mahajan Anita , Laack Nadia N , Pollock Bruce E 
Published: September 2021

Abstract
PurposeTo clarify the role of stereotactic radiosurgery (SRS) for atypical meningiomas (AM).MethodsA retrospective analysis of 68 patients with AM having SRS from 1995 until 2019. Nineteen patients (28%) had undergone prior external beam radiation therapy (EBRT) (median dose, 54 Gy). The median follow-up period was 52 months.ResultsEighteen (26%), 17 (25%), and 33 (49%) patients received SRS as an upfront adjuvant (≤ 6 months), early salvage (7-18 months), or late salvage treatment (> 18 months), respectively. The 3-, 5-, and 10-year progression-free survivals (PFSs) were 52%, 35%, and 25%, respectively. The 3-, 5-, and 10-year disease-specific survivals (DSSs) were 85%, 78%, and 61%, respectively. Adverse radiation events (AREs) were observed in 12 patients (18%), with increased or new seizures being the most frequent complication (n=7). Prior EBRT was associated with reduced PFS (HR = 5.92, P <0.01), reduced DSS (HR = 5.84, P <0.01), and an increased risk of ARE (HR = 3.31, P = 0.04). Timing of SRS was correlated with reduced PFS for patients having early salvage treatment compared to upfront adjuvant (HR = 3.17, P = 0.01) or late salvage treatment (HR = 4.39, P <0.01). Conclusion﻿PFS for patients with residual/recurrent AM remains poor despite SRS. Prior EBRT was associated with worse tumor control, higher tumor-related mortality, and an increased risk of ARE. Further study on the timing of SRS is needed to determine if upfront adjunctive SRS improves tumor control compared to salvage SRS.
Changes in The Liver Transcriptome and Physiological Parameters of Japanese Black Steers During The Fattening Period
Authors: Kim Minji , Masaki Tatsunori , Ikuta Kentaro , Iwamoto Eiji , Uemoto Yoshinobu , Terada Fuminori , Roh Sanggun 
Published: September 2021

Abstract
We investigated the physiological changes during the fattening period and production characteristics in Japanese Black steers bred and raised using the typical feeding system in Japan. Here, 21 Japanese black steers aged 12 months were used, and the experimental period was divided into early (12–14 months of age), middle (15–22 months), and late fattening phases (23–30 months). The liver transcriptome, blood metabolites, hormones, and rumen fermentation characteristics were analyzed. The blood triglyceride and non-esterified fatty acid concentrations increased, and blood ketone levels decreased, with fattening phases. Blood insulin increased with fattening phases and was higher in groups with high carcass weight and marbling. Rumen fermentation characteristics showed high propionate levels and low butyrate levels in late fattening phases, likely due to increased energy intake. Genes related to glucose metabolism, such as SESN3, INSR, LEPR, and FOXO3, were down-regulated in late fattening phases. Genes related to lipid metabolism, such as FABP4, were up-regulated, whereas FADS1 and FADS2 were down-regulated. These findings suggest that the physiological changes resulted from changes in the energy content and composition of diets. Liver metabolism changed with changes in fat metabolism. Insulin was strongly associated with physiological changes and productivity in Japanese Black cattle.
Risk factor modification reduced incidence of atrial fibrillation in an 18-year prospective cohort study: a time-updated analysis
Authors: Son Mi Kyoung , Song Dae Sub , Lee Kyoungho , Park Hyun-Young 
Published: September 2021

Abstract
Background

Although atrial fibrillation (AF) is an increasing health burden worldwide, strategies for AF prevention are lacking. This study aimed to identify modifiable risk factors (MRF) for and estimate their impact on AF risk in the midlife general population.
Methods

We assessed 9,049 participants who were free of prevalent AF at baseline from the Korean Genome and Epidemiology Study. Cox models with time-varying assessment of risk factors were used to identify significant MRF for incident AF. The MRF burden was defined as the proportion of times presented MRF during follow-up, based on the number of visits.
Results

Over a median follow-up of 13.1 years, 182 (2.01%) participants developed AF. In time-updated multivariable models accounting for changes in risk factors, three MRF including systolic blood pressure (SBP) more than 140 mmHg, obesity with central obesity, and an inactive lifestyle were significantly associated with incident AF. Compared to subjects with three MRF, those with one or no MRF had a decreased risk of AF (hazard ratio [95% CI] for one MRF, 0.483 [0.256–0.914]; and for no MRF, 0.291 [0.145–0.583]). A decreasing MRF burden was associated with reduced AF risk (hazard ratio [95% CI] per 10% decrease in SBP more than 140 mmHg, 0.937 [0.880–0.997]; in obesity with central obesity, 0.942 [0.907–0.978]; in inactivity, 0.926 [0.882–0.973]).
Conclusions

Maintenance or achievement of optimal MRF control was associated with decreased AF risk, suggesting that minimizing the burden of MRF might help prevent AF.
Altered Hippocampal Functional Connectivity Is Closely Related to Pain and Catastrophic Thinking Habits in Patients With Postherpetic Neuralgia
Authors: Kurosaki Hiromichi , Kan Shigeyuki , Terada Masaki , Shibata Masahiko , Kawamata Tomoyuki 
Published: September 2021

Abstract
Postherpetic neuralgia (PHN) is a chronic pain condition after a cure of herpes zoster. Patients with PHN often suffer from physical pain and psychological distress. We investigated the relationship between functional alternations in the brains of patients with PHN and their clinical manifestations using resting-state fMRI. We acquired resting-state fMRI data from 17 patients with PHN and matched healthy controls. We performed seed-based functional connectivity (FC) analysis and statistical comparisons in FC. We also performed correlation analysis between FC strengths and clinical scores about pain intensity, anxiety, depression and pain catastrophizing. In FC analysis, brain regions in the salience, default mode, sensorimotor and reward network were set as seeds. FC between the medial prefrontal cortex (mPFC) and hippocampus increased in PHN group. In contrast, FC between the hippocampus and primary somatosensory cortex (SI) decreased in PHN group. Furthermore, the SI-hippocampus FC was negatively correlated with pain intensity and the mPFC-hippocampus FC was positively correlated with pain catastrophizing tendency. Our findings indicate that the hippocampus is related to pain perception and catastrophic thinking habits in patients with PHN. Functional alteration of the hippocampus may have a major role in the development and maintenance of chronic pain condition in patients with PHN.
Characteristics of Sexual Behavior in Blind Males: a Cross-sectional Survey
Authors: Huang Shaoming , Zhu Shenghuang , Liu Renfu , Xiong Chuanchuan , Liu Lixin , Li Shuangshuang , Liu Shihan , Shu Yuan , Qian Biao , Huang Jiaguo 
Published: September 2021

Abstract
Objective: To investigate access to sexual knowledge, understanding of the sexual partners' beauty and sexual arousal in blind males and analyze the factors affecting them.Methods: A total of 54 blind males were conducted a face-to-face interview survey and questionnaire by the trained investigators. Results: The sound of mobile phones accounted for 51.9% of access to sexual knowledge, radio for 27.8%, the sound of television for 35.2%, and peer communication for 48.1%. The gentle and pleasant voice (64.8%) was most frequent on understanding of the sexual partners' beauty, followed by sexy and stylish figure (55.5%), fine and smooth skin (51.9%) and attractive body fragrance (18.5%). The results on the stimulation of sexual arousal showed that hearing gentle and pleasant sounds accounted for 40.7%, touching delicate and smooth skin for 44.4%, touching sexy and stylish figure for 53.7%, and pleasant mood for 22.2%. Conclusion: Blind males lack formal and systematic sex education in Ganzhou. And the understanding of the sexual partners' beauty mainly includes hearing, touch and smell. The stimulation of sexual arousal is mainly reflected in sound and touch, and pleasant mood also has a certain impact.
Factors Associated With Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea
Authors: camara Alimou , Diallo Penda Maladho , Diallo Mamadou Bobo , Nioké Talla , Cissé Adama , Sylla Mamadou Alpha , Lamah Gobounet , Diakité Mamady , Bah Amadou Sadio , Keita Mamadou Bhoye , Keita Alpha Kabinet , Conde Mamoudou , Kourouma Kaba , camara Robert , Koita Youssouf , Magassouba Fode Bangaly , camara Alioune , TOURE Abdoulaye Abdoulaye 
Published: September 2021

Abstract
BackgroundThe viral load has become an indispensable tool in evaluating antiretroviral therapy (ART) in people living with HIV / AIDS. This study aimed to assess virological suppression among in people living with HIV / AIDS on antiretroviral therapy in Guinea.MethodsThis was a descriptive cross-sectional study of more than three years that involved adult HIV-positive patients treated in different sites in Conakry. A total of 9815 viral load data were collected. The viral load was quantified by the Generic Biocentric technique and the detection threshold set at 350 copies/ml. Statistical analyses were performed by R software version R4.0.3..ResultsA total of 9815 viral load data collected at the national public health laboratory were analysed. The sample was dominated by women (72%), with an average age of 29 [29, 39]. Of these, 6,706 (68%) of HIV-positive people on ART had viral load suppression. The univaried analysis showed that women were 22% more likely to have VL suppression (p-value <0.001) moreover, the chance for all HIV-positive people on treatment to achieve viral load suppression was related to the length of treatment.Conclusionthe results of this study show viral load suppression greater than 68%. The length of antiretroviral therapy, female gender, and advancing age of PLHIV were all favourable to VL suppression.
The LOX-1 Receptor Ectopically Expressed in the Liver Alleviates Atherosclerosis by Clearing Ox-LDL in the Circulation
Authors: Wang Zhiwen , Chen Juan , Zeng Zhuanglin , Zhang Qing , Du Gaohui , Guo Xiaopeng , Wei Yumiao 
Published: September 2021

Abstract
Objective: Ox-LDL is the core factor in the development of atherosclerosis. However, there are few therapyaimed at eliminating Ox-LDL. Here in this study, we investigate whether the expression of the lectin-like oxidized low density lipoprotein receptor (LOX-1) in the liver could lead to the phagocytosis and degradationof circulating Ox-LDL and prevent the deposition of oxidized lipids in the vascular wall, thereby alleviatingthe progression of atherosclerosis.Methods: ApoE-/- mice were randomly divided into three groups, the control group,the AAV8-TBG-eGFP group and AAV8-TBG-LOX-1 group. In the viral group, mice received an injection of AAV8-TBG-LOX-1 (1.16×1011 virus genome (vg)/animal/100 μl). The mice in the control group and the AAV8-TBG-eGFP group received the same amount of sterile saline and AAV8-TBG-eGFP injections. The expression of LOX-1 in the liver was detected by immunofluorescent, Western blot and immunohistochemistry. The safety was assessed by H&E staining and blood biochemical analyses. The function of LOX-1 in the liver was detected by the co- localization of LOX-1 and Dil-Ox-LDL under laser scanning confocal microscope. The Ox-LDL in plasma was detected by ELISA. Changes in blood lipids were assessed through blood biochemical analysis. The pro- gression of atherosclerotic lesions was detected by oil red O（ORO） staining. And the expression of VCAM- 1 in endothelial cells and the extent of macrophages in plaques were detected by immunofluorescence staining. The protein expression in liver was assessed by qRT-PCR and Western blot. Results: The expression of LOX-1 was stable in liver within 4 weeks. Ectopically expressed LOX-1 in the liver phagocytosed and degraded Ox-LDL and reduced Ox-LDL in circulating plasma but did not have a significant effect on blood lipid levels. After the expression of LOX-1 in liver, Ox-LDL can be cleared by the liver, thereby reducing VCAM-1 expression in vascular endothelium and migration of macrophages in plaques, and eventually alleviating the progression of atherosclerosis. Hepatic LOX-1 expression may facilitate the metabolic clearance of Ox-LDL by upregulating the expression of ABCG5/G8. Conclusions: Ectopic liver-specific expression of LOX-1 alleviates the progression of atherosclerosis by clearing Ox-LDL in circulation.
Cardiovascular, diabetes, and cancer strips: New evidences from clinical cases in Nanchang, China
Authors: Hu Chunsong , Huang Guomei , Han Hong , Zou Lelan , Liu Liyu , Xiao Wen , Zhang Ying , Wu Qinghua 
Published: September 2021

Abstract
Since cardiovascular, diabetes, and cancer (CDC) strips were discovered, more and more evidences support this new concept. Here, we report that clinical features and shared major risk factors (SMRF) of the CDC strips as well as the distribution of hypertension, diabetes, and cancer in Nanchang, China. It aims to provide new and solid clinical evidences by cases randomly collected and carefully screened from 2012/2013 to 2017. Typical cases with the CDC strips were presented with unhealthy “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] related SMRF, the distribution of hypertension, diabetes, and cancer was approximately 2:1:4, and the distribution of various cancer cases was also presented. A graphical abstract showed the association of CDC strips with SMRF. In conclusion, there are indeed the CDC strips due to new and solid clinical evidences, and the CDC strips highly link to unhealthy E(e)SEEDi related SMRF.
Synthesis of a magnetic C@Co material via the design of a MOF precursor for efficient and selective adsorption of water pollutants
Authors: Liu Yu , Wang Yan , Zhang Xiao-Sa , Li Wen-Ze , Yang Ai-Ai , Luan Jian , Liu Hong-Zhu , Wang Zhong-Gang 
Published: September 2021

Abstract
3D metal-organic frameworks (MOFs) can be appropriate templates for the fabrication of nanomaterials due to they have active sites exposed on the channel or surface, which thus provide them with improved catalytic performance. In this study, a 3D cobalt-based MOF [Co(H2bpta)]n (Co-MOF), where H4bpta denotes 2,2′,4,4′-biphenyltetracarboxylic acid, has been constructed with the use of a ligand with a high carbon content. On this basis, a 2D magnetic carbon-coated cobalt nanoparticle composite (C@Co) was prepared by using the title MOF. Magnetic C@Co can readily absorb dye from the solution and can thus act as an inexpensive and fast-acting adsorbent. Moreover, we have explored the adsorption isotherms, kinetics and thermodynamics of the anion dyes in detail. The adsorption capacity of the C@Co for investigated methyl orange (MO) and congo red (CR) dyes were 773.48 and 495.66 mg g− 1, respectively. It is noteworthy that MO adsorption is higher in existing materials. Thermodynamic studies suggest that the adsorption processes are spontaneous and exothermic. This study opens a new insight into the synthesis and application of carbon-based materials that enable the selective removal of organic dyes.
Bone marrow mesenchymal stem cell-derived exosomes attenuate the maturation of dendritic cells and reduce the rejection of allogeneic skin transplantation in mice model
Authors: ZHAO RENLI , Lai Guohua , Deng Zhiwei , Zhuang Weida , Wu Mingjie , Wu Jiachang , Sang Hongxun 
Published: September 2021

Abstract
Background

Bone mesenchymal stem cells (BMSCs)-derived exosomes (B-exos) are attractive for applications in enabling alloantigen tolerance. An in-depth mechanistic understanding of the interaction between B-exos and dendritic cells (DCs) could lead to novel cell-based therapies for allogeneic transplantation. Herein, the potential of a B-exos-based application combined with DCs was explored for inducing allogeneic transplant tolerance.
Methods

After mixed culture of BMSCs and DCs for 48 hours, DCs from the upper layer were collected to analyze the expression levels of surface markers and mRNAs of inflammation-related cytokines. Then the DCs were co-cultured with B-exo before being collected to detect the mRNA and protein expression levels of indoleamine 2,3-dioxygenase (IDO). The treated DCs from different groups were co-cultured with naïve CD4 + T cells from the mouse spleen. The proliferation of CD4 + T cells and the proportion of CD4 + CD25 + Foxp3 + T cells were analyzed. Finally, the skins of BALB/c mice were transplanted to the back of C57 mice to establish a mouse allogeneic skin transplantation model.
Results

The coculture of DCs with BMSCs in a trans-well system downregulated the expression of the major histocompatibility complex class II (MHC-II) and CD80/86 costimulatory molecules on DCs, as well as the mRNA expression of interleukin-10 (IL-10), IL-12, and transforming growth factor-β (TGF-β). However, these findings were abolished when treated with GW4869. Moreover, B-exos (5 µg/mL) increased the expression of indoleamine 2,3-dioxygenase (IDO) in DCs treated with lipopolysaccharide (LPS) compared to the control cells. CD4 + CD25 + Foxp3 + T cells increased when cultured with B-exos-exposed DCs, which was attenuated by 1-methyl tryptophan (1MT). Mice recipients injected with B-exos-treated DCs significantly prolonged the skin allograft survival. The allografts showed slight cell infiltration and significantly preserved graft structure. Also, the level of CD4 + CD25 + Foxp3 + T cells was significantly higher in B-exos-exposed DCs recipient animals than that in other groups.
Conclusions

Taken together, these data suggested that the B-exos suppress the maturation of DCs and increase the expression of IDO, which might shed light on the role of B-exos in inducing alloantigen tolerance.
Research on Ground Liquefaction and Structural Force Characteristics of Underground Utility Tunnels Under CLC Stratigraphic Model
Authors: Tian Tian , Yao aijun , Gong Yifei , Guo Yaozhen 
Published: September 2021

Abstract
Damages to underground structures due to liquefaction of the soils caused by cyclic loads such as earthquakes have always been an important issue in geotechnical underground engineering practices. This paper presents a numerical study of the utility tunnels at different burial depths in "Coh-Liq-Coh" horizontally layered liquefiable grounds using the finite-difference program FLAC3D. "Finn-Byrne" cyclic load volumetric strain increment model simulates the fluid-solid coupling of saturated sand and the increase in pore water pressure during vibration. The numerical model was loaded using an acceleration sine wave for dynamic calculations. The numerical results showed that the burial depths have a strong influence on the liquefaction of the soil beneath the utility tunnels and on the forces and deformations of the structures. Under the numerical simulation conditions in this paper, the greater the burial depth, the greater the liquefaction of the soil beneath the structure, the greater the shear stress on the side walls and the smaller the settlement difference between the structure and the surrounding soil. In the numerical simulations in this paper, a reasonable burial depth for utility tunnels was 0.8 to 1.1 times of the structure height.
Biotic and Abiotic Sources of Stress on Wild Rocket Classified by Leaf-image Hyperspectral Data Mining With an Artificial Intelligence Model
Authors: Navarro Alejandra , Nicastro Nicola , Costa Corrado , Pentangelo Alfonso , Cardarelli Mariateresa , Ortenzi Luciano , Pallottino Federico , Cardi Teodoro , Pane Catello 
Published: September 2021

Abstract
BackgroundWild rocket (Diplotaxis tenuifolia) is prone to soil-borne stresses under intensive cultivation systems devoted to ready-to-eat salad chain, increasing needs for external inputs. Early detection of the abiotic and biotic stresses by using digital reflectance-based probes may allow optimization and enhance performances of the mitigation strategies.Methodshyperspectral image analysis was applied to D. tenuifolia potted plants subjected, in a greenhouse experiment, to five treatments for one week: a control treatment watered to 100% water holding capacity, two biotic stresses: Fusarium wilting and Rhizoctonia rotting, and two abiotic stresses: water deficit and salinity. Leaf hyperspectral fingerprints were submitted to an artificial intelligence pipeline for training and validating image-based classification models able to work in the stress range. Spectral investigation was corroborated by pertaining physiological parameters. ResultsWater status was mainly affected by water deficit treatment, followed by fungal diseases, while salinity did not change water relations of wild rocket plants compared to control treatment. Biotic stresses triggered discoloration in plants just in a week after application of the treatments, as evidenced by the colour space coordinates and pigment contents values. Some vegetation indices, calculated on the bases of the reflectance data, targeted on plant vitality and chlorophyll content, healthiness, and carotenoid content, agreed with the patterns of variations observed for the physiological parameters. Artificial neural network helped selection of VIS (492-504, 540-568 and 712-720 nm) and NIR (855, 900-908 and 970 nm) bands, whose read reflectance contributed to discriminate stresses by imaging. ConclusionsThis study provided significative spectral information linked to the assessed stresses, allowing the identification of narrowed spectral regions and single wavelengths due to changes in photosynthetically active pigments and in water status revealing the etiological cause.
Production practices, trends, constraints and opportunities of beekeeping in Arba Minch Zuria District, Southern Ethiopia
Authors: Anza Alemayehu , Yemane Nebiyu , Bezabeh Amssalu 
Published: September 2021

Abstract
Background

Beekeeping is an integral component of animal husbandry and it has highly untapped potential for generating household income for rural livelihood. The study was conducted to assess beekeeping practices, honey production trends, constraints and opportunities of beekeeping in Arba Minch Zuria District of Gamo Zone, Southern Ethiopia. The district was selected purposively based on its beekeeping potential and stratified into three agro-ecological zones. Seven representative Kebeles from the District were selected proportional to their agro-ecological variations. A total of 156 beekeepers were selected using systematic random sampling technique. Cross-sectional type of study was conducted to generate data through formal survey. The quantitative and qualitative data were summarized and analysed using one way ANOVA and cross tabulations, respectively.
Result

Mixed crop-livestock farming system was primary means of livelihood in the study area. The result revealed that most (96.8%) of the beekeepers practiced traditional beekeeping system. The average honeybee stocks were about 4.8 ± 1.78 and 5.2 ± 6.98 colonies per household. The average honey yield was 5.8 ± 0.09 kg and 20.1 ± 0.31 kg per year for traditional and modern beehives, respectively.
Conclusion

There was a decreasing trend of total colony number and honey yield over the last five years (2014–2018). Shortage of bee forage during dearth periods, absconding and honeybee enemies were the most important constraints of beekeeping in the study area, while the availability of huge number of honeybee colonies, existence of ample bee forages and the existence of tourist attraction sites in the study area provides a good market opportunity to sell the honey with a premium price.