bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПОВЫШЕНИЕ ЭФФЕКТИВНОСТИ ИЗБИРАТЕЛЬНОЙ КИСЛОТНОЙ ОБРАБОТКИ СКВАЖИН ПУТЕМ ПРИМЕНЕНИЯ ТОЧЕЧНОЙ ГИДРОПЕСКОСТРУЙНОЙ ПЕРФОРАЦИИ
Authors: Хабибуллин Марат Яхиевич , Гилаев Гани Гайсинович 
Published: February 2021

Актуальность исследования обусловлена необходимостью обеспечивать точечное распространение кислотного раствора при проведении кислотной обработки призабойной зоны эксплуатационной скважины. Используя данный метод, повышается эффективность проведения данного процесса путем более глубокого растворения известняковой породы в призабойной зоне скважины и тем самым полнейшего открытия каналов для поступления пластовой жидкости из пласта в скважину. Цель: разработать и предложить метод точечной гидропескоструйной перфорации при кислотной обработке призабойной зоны эксплуатационной скважины, методику его применения и создать конструкции подземного и наземного оборудования скважин для осуществления разработанного метода. Объекты: лабораторный стенд с приспособлением моделирующего канал в породе; гидропескоструйный перфоратор при гидропескоструйном вскрытии; фиксатор гидравлический, предназначенный для предупреждения об­рыва и снятия растягивающих напряжений в колонне труб при гидропескоструйном вскрытии и для фиксации при центро­вании перфоратора в заданном интервале обработки; кислотный раствор на основе соляной кислоты объемом 3–4 м3; продавочная жидкость. Методы. Экспериментальное исследование величины давления в канале при точечной гидропескоструйной перфорации проводили на стенде. В приспособлении устанавливали насадку и штуцер определенных диаметров – d и D – на необходимом расстоянии между ними. На­сосным агрегатом прокачивали жидкость при давлении перед на­садкой р1 и фиксировали давление внутри патрубка р2. В опытах в качестве рабочей жидкости использовали воду и водный рас­твор сульфит-спиртовой барды с вязкостью 12,65 сПз при температуре 20 °С. Процесс избирательной кислотной обработки состоит в том, что в скважину спускают гидропескоструйный перфоратор, устанавливая его на уровне выбранного интервала обработки, и гидравлические фиксаторы, необходимые для строгого удержания перфоратора. После этого закачивают 3–4 м3 кислотного раствора и продавочную жидкость. Затем в насосно-компрсссорные трубы и затрубное пространство нагнетают воздух или газ (до максимального давления в распределительной будке), и в таком состоянии скважину оставляют под давлением на 20 ч, и по окончании скважину дренируют для извлечения продуктов реакции на поверхность. Результаты. Из анализа результатов многократной (трехкратной) гидро­кислотной обработки видно, что первоначальное дав­ление закачки кислотного раствора после первого этапа обработки скважины было снижено на 24 %, а после второго – на 55 %. Метод кислотной обработки с дополнительной точной перфорацией призабойной зоны эксплуатационных скважин позволяет более эффективнее проводить процесс обработки. В результате увеличивается объем притока пластовой жидкости из пласта в скважину на 20…30 % в сравнении с обычной кислотной обработкой.
ГЕОЛОГО-ФИЗИЧЕСКИЕ ОСОБЕННОСТИ РАЗРАБОТКИ СЛАБОКОНСОЛИДИРОВАННЫХ КОЛЛЕКТОРОВ ВЯЗКОЙ НЕФТИ
Authors: Ильясов Ильнур Рустамович , Грачев Сергей Иванович 
Published: February 2021

Актуальность. Восточно-Мессояхское месторождение является уникальным не только по размеру геологических запасов, но и по своим геологическим особенностям. Основной продуктивный пласт ПК1-3 содержит около 65 % запасов и представляет собой слабоконсолидированный коллектор с высоковязкой нефтью. Опыта разработки аналогичных месторождений в условиях материковой Арктики практически нет. Исследование геолого-физических особенностей разработки слабоконсолидированных коллекторов вязкой нефти является актуальной задачей. Цель: провести анализ и выявить ключевые геолого-физические особенности разработки слабоконсолидированных коллекторов вязкой нефти для поиска методов и технологий повышения эффективности их разработки. Объекты: эксплуатационные слабоконсолидированные коллектора вязкой нефти Восточно-Мессояхского месторождения. Методы: критический анализ, контент-анализ, анализ и обобщение имеющегося опыта разработки слабоконсолидированных коллекторов вязкой нефти на примере пласта ПК 1-3 Восточно-Мессояхского месторождения. Результаты. Проведен критический анализ результатов исследования ключевых геолого-физических характеристик пласта ПК 1-3 и его флюидов, которые необходимо учитывать для его максимально эффективной разработки. Составлен перечень ключевых особенностей. Показано их влияние на эффективность разработки. Проведен анализ опыта заводнения, анализ работы аквифера и его влияния на режим разработки. Доказана необходимость применения вторичных методов разработки пласта ПК 1-3 и системы поддержания пластового давления. Однако ввиду описанных выше особенностей традиционное заводнение слабоконсолидированных коллекторов вязкой нефти сопряжено с высокими рисками прорывов воды и низким коэффициентом охвата пласта заводнением, что будет оказывать большое влияние на эффективность разработки и конечный коэффициент извлечения нефти. Сделан вывод об необходимости исследования альтернативных технологий и агентов заводнения слабоконсолидированных коллекторов вязкой нефти, в том числе с применением физико-химических методов увлечения нефтеотдачи с системным подходом, что является актуальной и интересной задачей.
Alternative education approaches and their effects onthe learning space
Authors: Turk S. Aybike , Sari Reyhan Midilli 
Published: February 2021

Today, the training method called ‘traditional education system’ is uniform, teacher-centered, connected to the book, and has a penalty–reward system. This has led to criticism of traditional education and the emergence of alternative perspectives in education. The ‘alternative education approaches’ are called new educational approaches. The spatial arrangements of these educational approaches are the most noticeable points. In this study, three alternative education approaches are discussed. These three approaches focus on spatial arrangements caused by educational philosophies. The main purpose of the study is to examine the close relationship between educational philosophies and educational spaces. In this study, education philosophy of each of these alternative education approaches was first explained and educational principles were determined. Then discussed about the sort of arrangements made on the space and how the space organisation was shaped. It has emerged that the ‘spaces’ and ‘space organisations’ in which education is given are shaped according to the basic philosophy of the center of education.

Keywords: Alternative education approaches, educational space, learning space, educational methods.
Transformation of basic design teachings into product: interior furniture
Authors: Erbay Muteber , Ustaömeroğlu Ayça A. , Küçük Pınar , Sadıklar Zeynep 
Published: February 2021

In design-based disciplines, the basic design lesson generally covers theories of design elements-principles and Gestalt perception rules, then followed by two and three-dimensional abstract designs made by the students. All these studies play an important role in the development of visual language and expression. Particularly in the visualization of the imagination and in the process of transferring the design, the students are fed from these teachings and direct their design decisions. For this reason, the "Basic Design" course is of great importance for the students to develop a formal and aesthetic perspective. However, the transformation of these abstract thoughts into a concrete product is often not tested in the context of the course. In the scope of this study; the teachings that students gained from the "Basic Design" course, which is given in the first semester in the Department of Interior Design at Karadeniz Technical University, was tested with a workshop. As method of the study, the functional characteristics of the furniture designed by the students and the basic design elements-principles and Gestalt perception rules used by the students were entered into the SPSS program and the obtained data were evaluated in accordance with the objectives of the study.
Keywords: Furniture design; abstract thinking; design education; basic design; creativity

Özet
Tasarım tabanlı disiplinlerde temel tasarım dersi genel olarak; tasarım ögeleri, ilkeleri, Gestalt algı kuramlarını içeren teorikanlatımlarla verilmekte, sonrasında öğrencilere yaptırılan iki ve üç boyutlu soyut tasarımlarla desteklenmektedir. Tüm buçalışmalar görsel dilin ve ifadenin geliştirilmesinde önemli bir rol oynamaktadır. Özellikle imgenin görselleştirilmesinde vetasarıma aktarılması aşamasında öğrenciler, bu öğretilerden beslenerek tasarım kararlarına yön vermektedirler. Bu nedenle“Temel Tasarım” dersi, öğrencilerin biçimsel ve estetik bir bakış açısı geliştirebilmeleri için büyük bir önem arz etmektedir.Ancak bu bakış açısının soyut düşünceden, somut bir ürüne dönüştürülmesi genellikle ders kapsamında test edilememektedir.Bu çalışma kapsamında; Türkiye’nin kuzey doğusunda bir sahil kenti olan Trabzon’da bulunan Karadeniz Teknik Üniversitesi İçMimarlık Bölümünde birinci yarıyılda verilmekte olan “Temel Tasarım” dersinin bir çıktısı olarak öğrencilerin derstenedinimleri dönem sonunda bir workshop çalışması ile sınanmıştır. Çalışmanın yöntemi olarak öğrencilerin tasarladıklarımobilyaların işlevsel özellikleri ve kullandıkları temel tasarım öge-ilkeleri ve Gestalt algı kuralları SPSS programına girilmiş,elde edilen veriler çalışmanın amaçları doğrultusunda değerlendirilmiştir. Anahtar Kelimeler: Mobilya tasarımı; soyut düşünme; tasarım eğitimi; temel tasarım; yaratıcılık
PEMAKNAAN REALITAS KEKERASAN SEKSUAL, PRAKTIK PATRIARKI, DAN FEMINISME DALAM FILM HUSH
Authors: Khotimah Khusnul 
Published: February 2021

<p>Through the issue of sexual violence as a manifestation of patriarchy practices and the emergence of feminist discourse as a way of discharge. This study attempted to see this further when it was constructed in a film called hUSh. The aim of the study wanted to know the extent of the audience's understanding of the reality of sexual violence, as well as the values of patriarchy and feminism in the film using Max Weber's Verstehen approach. Qualitative decectory methodology is used so that this research can objectively see the process of understanding the audience through interviews conducted after watching hUSh Film, to see their subjectivity to the reality of sexual violence, patriarchy, and feminism</p><p> </p>
KEARIFAN LOKAL DALAM MEMBANGUN KETAHANAN PANGAN PETANI
Authors: Sari Intan Purnama , Zuber Ahmad 
Published: February 2021

<div class="page" title="Page 25"><div class="layoutArea"><div class="column"><p><span>Tujuan penelitian ini untuk mengetahui bagaimana kearifan lokal dalam sistem produksi pertanian dalam membangun ketahanan pangan petani di Desa Pascarejo. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus. </span>Hasil penelitian menunjukkan bahwa sistem produksi pertanian yang dilakukan oleh petani merupakan hasil dari adaptasi lingkungan alam serta pengalaman bertani yang telah dilakukan bertahun- tahun lamanya. Melalui kearifan lokalnya, petani memiliki strategi-strategi yang dilakukan untuk membangun ketahanan pangan keluarga. Faktor pendukung adanya kelompok tani sebagai wadah pemberdayaan petani dalam membahas masalah pertanian, sedangkan faktor penghambat adalah terbatasnya ketersediaan air. Melalui kearifan lokalnya, petani di Desa Pacarejo dapat membangun ketahanan pangan keluarga.</p></div></div></div>
UPAYA KOMUNITAS PEDULI SUNGAI DALAM PELAKSANAAN KONSERVASI SUNGAI BAKI DI KABUPATEN SUKOHARJO
Authors: Priambudi Hendrata Wahyuesa , Utami Trisni 
Published: February 2021

<div class="page" title="Page 36"><div class="layoutArea"><div class="column"><p><span>Peran masyarakat dalam menciptakan dan menjaga kelestarian sungai sangat berpengaruh baik terhadap lingkungan alam maupun pada kehidupan masyarakat. Adanya kesadaran dari masyarakat terhadap masalah pencemaran sungai, menciptakan perilaku dan gerakan dari dalam diri masyarakat untuk berupaya sedemikian rupa melakukan konservasi sungai. Dalam upayanya melakukan konservasi sungai, masyarakat di Desa Menuran yang tergabung dalam Komunitas Masyarakat Peduli Kali Baki membentuk sebuah gerakan yang bertujuan untuk melakukan konservasi sungai dan menjaga kelestarian sungai, namun di sisi lain juga dapat dimanfaatkan sumber daya yang ada di sungai tersebut untuk kebutuhan masyarakat sekitar. Pada penelitian ini digunakan metode kualitatif deskriptif untuk menjawab bagaimana Komunitas Masyarakat Peduli Kali Baki melakukan upaya konservasi Sungai Baki dan mensosialisasikan kepada masyarakat dan dari hasil penelitian tersebut, secara keseluruhan dianalisis menggunakan Konsep AGIL yang dikemukakan oleh Talcott Parsons dalam teori Struktural Fungsional. Dari penelitian ini ditemukan bahwa Komunitas Masyarakat Peduli Kali Baki melakukan sosialisasi yang cenderung partisipatoris dan melakukan upaya konservasi sungai seperti pemanfaatan, perlindungan, dan pemeliharaan sungai secara berkala supaya sungai mampu </span><span>sustainable </span><span>di masa mendatang.</span></p></div></div></div>
Soft-Tissue Balancing in Total Hip Arthroplasty
Authors: Boe Richard A. , Selemon Nicolas A. , Eachempati Krishna Kiran , Paprosky Wayne G. , Sheth Neil P. 
Published: February 2021

» Appropriate total hip arthroplasty (THA) reconstruction must simultaneously address component position, restoration of biomechanics, and soft-tissue balance.» Preoperative planning for complex THA cases should include radiographic templating, a detailed case plan that contains backup implant options, and a thorough understanding of the patient’s preoperative examination.» Using a systematic approach to soft-tissue balancing in THA enhances the ability to intraoperatively execute the preoperative plan.» In patients with preexisting deformities (e.g., dysplasia or prior surgery), increased attention to abductor function is necessary when assessing acetabular component placement and offset.
WITHDRAWN: Visual Similarity Versus Mental Rotation For Inverted and Upright Faces.
Authors: Rakover Sam S. , Bar-On Rani A. , Gliklich Anna 
Published: February 2021

Abstract
A major interest of research in face recognition lies in explaining the Face Inversion Effect (FIE), in which the recognition of an inverted face is less successful than that of an upright face. However, prior research has devoted little effort to examining how the cognitive system handles comparison between upright and inverted faces. In two experiments, such comparison is found to be based on visual similarity rather than on mental rotation of the inverted face to upright. Visual similarity is based on certain elements mutual to the two faces, which resist the transformation of inversion. These elements are symmetrical or salient components of the face, such as round eyes or thick lips.
Prognostic factors for mortality in invasive pneumococcal disease: a system review and meta-analysis
Authors: Chen Hao , Matsumoto Hiromi , Horita Nobuyuki , Hara Yu , Kobayashi Nobuaki , Kaneko Takeshi 
Published: February 2021

Abstract
Risk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, and Web of Science, comprising 26 reports in total. Overall mortality for invasive pneumococcal disease was reported as 20.8% (95% confidence interval (CI) 17.5–24%). Factors associated with mortality were age (odds ratio (OR) 3.04, 95%CI 2.5–3.68), nursing home (OR 1.62, 95%CI 1.13–2.32), nosocomial infection (OR 2.10, 95%CI 1.52–2.89), septic shock (OR 13.35, 95%CI 4.54–39.31), underlying chronic diseases (OR 2.34, 95%CI 1.78–3.09), solid organ tumor (OR 5.34, 95%CI 2.07–13.74), immunosuppressed status (OR 1.67, 95%CI 1.31–2.14), and alcohol abuse (OR 3.14, 95%CI 2.13–4.64). Mortality rates with invasive pneumococcal disease remained high, and these findings may help clinicians provide appropriate initial treatment for this disease.Key points: The overall mortality rate from IPD has remained high, at 20.8% and older age, septic shock, immunosuppressed status, underlying chronic diseases, solid organ tumor, alcohol abuse, nursing home, and nosocomial infection were prognostic factors for mortality from IPD.
An autism-associated mutation in salt inducible kinase 1 causes repetitive behavior and social deficits due to enhanced excitatory neuronal functions in mice.
Authors: Badawi Moataz , Mori Takuma , Kurihara Taiga , Yoshizawa Takahiro , Nohara Katsuhiro , Kouyama-Suzuki Emi , Yanagawa Toru , Shirai Yoshinori , Tabuchi Katsuhiko 
Published: February 2021

Abstract
Background:Six mutations in the salt inducible kinase 1 (SIK1) coding gene have been identified in the early infantile epileptic encephalopathy (EIEE-30) patients accompanied by autistic symptoms, such as repetitive behavior and social behavioral deficits. Among these mutations, two are nonsense mutations that truncate the C-terminal region. It has been shown that the C-terminal truncated form of SIK1 protein affects the subcellular distribution of SIK1 protein, tempting to speculate the relevance to the pathophysiology of the disorders.Methods:We generated SIK1 mutant (SIK1-MT) mice recapitulating the C-terminal truncated mutations using CRISPR/Cas9-mediated genome editing. We performed cellular assays to examine the subcellular localization of SIK1-MT. We also performed patch clamp electrophysiological recording and behavioral tests to evaluate the neuronal functions and behaviors in SIK1-MT mice. Pharmacological experiments using risperidone were also performed to examine the potential therapeutics of the disorder.Results:SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. We also found the increased repetitive behavior and social behavioral deficits in SIK1-MT mice. The risperidone administration attenuated the neural excitability and excitatory synaptic transmission, but the disrupted E/I synaptic balance was unchanged because it also reduced the inhibitory synaptic transmission. Risperidone also eliminated the repetitive behavior, but not social behavioral deficits.Limitations:We failed to identify drugs that can cure the social behavioral deficits in this mouse model.Conclusions:In the present study, we generated model mice for EIEE-30 recapitulating C-terminal truncated SIK1 mutation discovered in human patients. We found that the C-terminal deletion of SIK1 affects the subcellular distribution of SIK1, resulting in the elevated excitability of neuronal networks and autistic behaviors in the mutant mice. Repetitive behavior, but not social deficits, was restored by risperidone, probably due to the decrease of both excitatory and inhibitory synaptic functions by the drug.
Insight into the mechanisms of terminal HS-tolerance in wheat mutant with improved nutritional quality through de novo transcriptome sequencing
Authors: Kumar Ranjeet Ranjan , Bakshi Suman , Dubey Kavita , Hasija Sumedha , Rai Gyanendra K. , Jain Neelu , Jambhulkar Sanjay , Singh Bhupinder , Singh Gyanendra Pratap , Praveen Shelly 
Published: February 2021

Abstract
Terminal HS is one of the main bottle-neck in wheat yield and grain-quality. Here, we have developed wheat mutant (M3) for HS-tolerance [parent-MP3054- C-306/CB.SPRING BW/CPAN2072 (Parentage)]. To elucidate the mechanism of thermotolerance in mutant, we performed de novo transcriptomic sequencing of mutant (M3), parent (P3), and mutant exposed to HS (M3H). We sequenced 6.5, 7.5, and 7.0 million reads in P3, M3 and M3H and generated 3,05,537 genes and 5,88,788 transcripts with an N50 of 1,349 bp. We observed 6,120 upregulated and 4,428 downregulated transcripts (M3 vs P3), 11,354 upregulated and 12,408 downregulated genes (M3H vs P3) and 4817 upregulated and 9085 downregulated genes (M3H vs M3). Some of the highly upregulated genes observed were HSP20, SOD, ABC transporters, HSF, etc. and downregulated genes were starch synthase, sucrose synthase, etc. Gene Ontology analysis showed ‘ATP-binding’ to be most enriched category. Carbon metabolism pathway was observed most altered under HS. We identified 41940 SSRs, 1,10,772 SNPs and 2432 InDels. Potential markers were observed lying on HSP, SOD, STK, and starch synthase. Biochemical markers based characterization showed wheat mutant to be better in HS-tolerance and grain-quality, as compared to parent.
CAB39 mediates epithelial-mesenchymal transition via activation of NF-κB signaling to facilitate bladder cancer invasion and metastasis
Authors: Chao Haichao , Peng Lifen , Deng Leihong , Yu Zhaojun , Deng Huanhuan , Xu Fanghua , Xu Xiangda , Huang Jianbiao , Zeng Tao 
Published: February 2021

Abstract
Background

Bladder cancer (BC) is the most common urinary cancer among men with a high mortality rate despite of constant advancement in medical and therapeutic treatment. Recent evidence demonstrated that CAB39 plays a critical role in BC pathogenesis by exhibiting various biological activities, but the underlying molecular mechanisms remain unclear. The aim of this research was to define the expression patterns of CAB39 in normal and tumor tissues and explore its biological function in epithelia-mesenchymal transition (EMT) in human BC.

Methods

Immunohistochemistry and Quantitative RT-PCR analyses were used respectively to examine the expression of CAB39 in BC tissues and cell lines with different metastatic potentials. In addition, the clinical significance of CAB39 expression was also evaluated. Wound-healing assay, cell invasion assay, and CCK8 proliferation assay in cell lines in which CAB39 was knocked down by shRNA, as well as xenograft tumor models in nude mice, were performed to assess the effect of CAB39 reduction on invasion, migration, and proliferation of BC cells. The GSEA database was used to analyze panel of genes enriched as a result of elevated CAB39 expression in BC cells, and the results were validated by western blot analysis.

Results

The level of CAB39 protein was up-regulated in invasive but not in noninvasive bladder cancer tissues. Elevated expression of CAB39 was inversely correlated with prognosis of the malignant disease. Additionally, CAB39 was differentially expressed in T24, 5637, and J82 bladder cancer cell lines with highest expression in T24, the most invasive cell line among the three. However, shRNA-mediated attenuation of endogenous CAB39 in T24 and 5637 cell lines reversed such invasive and metastatic effects as demonstrated by the inhibition of tumorigenesis in nude mice xenografts. Furthermore, we demonstrated that CAB39 could mediate EMT through upregulation of N-cadherin and downregulation of E-cadherin in BC via NF-kB signaling pathway.

Conclusions

Our study reveals a previously unknown mechanism of CAB39-mediated EMT in promoting invasion and metastasis of BC and provides a rationale for future investigation of CAB39 as a potential target for the development of novel therapeutic agents to fight the malignancy.