bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photoperiod is involved in the regulation of seasonal breeding in male water voles (Arvicola terrestris)
Authors: Poissenot Kevin , Chorfa Areski , Moussu Chantal , Trouillet Anne-Charlotte , Brachet Morgane , Chesneau Didier , Chemineau Philippe , Ramadier Etienne , Pinot Adrien , Benoit Etienne , Lattard Virginie , Dardente Hugues , Drevet Joël , Saez Fabrice , Keller Matthieu 
Published: September 2021

ABSTRACT
Mammals living at temperate latitudes typically display annual cyclicity in their reproductive activity: births are synchronized when environmental conditions are most favorable. In a majority of these species, day length is the main proximate factor used to anticipate seasonal changes and to adapt physiology. The brain integrates this photoperiodic signal through key hypothalamic structures, which regulate the reproductive axis. In this context, our study aimed to characterize regulations that occur along the hypothalamo–pituitary–gonadal (HPG) axis in male fossorial water voles (Arvicola terrestris, also known as Arvicola amphibius) throughout the year and to further probe the implication of photoperiod in these seasonal regulations. Our monthly field monitoring showed dramatic seasonal changes in the morphology and activity of reproductive organs, as well as in the androgen-dependent lateral scent glands. Moreover, our data uncovered seasonal variations at the hypothalamic level. During the breeding season, kisspeptin expression in the arcuate nucleus (ARC) decreases, while RFRP3 expression in the dorsomedial hypothalamic nucleus (DMH) increases. Our follow-up laboratory study revealed activation of the reproductive axis and confirmed a decrease in kisspeptin expression in males exposed to a long photoperiod (summer condition) compared with those maintained under a short photoperiod (winter condition) that retain all features reminiscent of sexual inhibition. Altogether, our study characterizes neuroendocrine and anatomical markers of seasonal reproductive rhythmicity in male water voles and further suggests that these seasonal changes are strongly impacted by photoperiod.
Determination of a cone-beam CT low-dose protocol for root fracture diagnosis in non-endodontically treated anterior maxillary teeth
Authors: Andraws Yalda Fedil , Theodorakou Chrysoula , Clarkson Rosalyn J , Davies Jonathan , Feinberg Lee , Sengupta Anita , Horner Keith 
Published: September 2021

Objectives: The aim of this study was to determine a “low-dose protocol” which provides acceptable diagnostic accuracy for detection of root fractures in unrestored anterior maxillary teeth, using an ex vivo model. Methods: 48 maxillary anterior teeth, half with horizontal or oblique root fractures, were imaged using CBCT in an anthropomorphic model. Nine X-ray exposure combinations were used, including the manufacturer’s standard (“reference”) exposure and high-resolution settings (“HiRes”), by varying kV, exposure time, and rotation angle. Measurements of Dose Area Product (DAP) were recorded. Five dental radiologists assessed the scans for root fractures and judged image quality. Parameters of diagnostic accuracy were calculated, including area under the Receiver Operating Characteristic curve (Az). Objective measures of image quality were made at the same exposure combinations using an image quality phantom. Results: Although there was a significant linear relationship between DAP and mean Az, only the lowest DAP exposure combination had a mean Az significantly different to the reference exposure. There was no significant effect on other diagnostic accuracy parameters when using HiRes compared with the reference exposure. There was a significant positive relationship between DAP and contrast resolution. HiRes did not significantly improve contrast resolution and made a small improvement to spatial resolution. Conclusions: Scope existed for radiation dose reduction compared with the manufacturer’s guidance. There was no improvement in diagnostic accuracy using HiRes settings. A cautious recommendation for this CBCT machine is that it is possible to achieve a dose reduction of about 20% compared with the reference exposure parameters.
Is Equality Always Desirable? Analyzing the Trade-Off Between Fairness and Attractiveness in Crew Rostering
Authors: Breugem Thomas , Dollevoet Twan , Huisman Dennis 
Published: September 2021

Millions of employees around the world work in irregular rosters. The quality of these rosters is of utmost importance. High-quality rosters should be attractive on an individual level, but also divide the work fairly over the employees. We develop novel methodology to compute the trade-off between fairness and attractiveness in crew rostering. First, we propose an intuitive fairness scheme for crew rostering and analyze its theoretical performance. To do so, we introduce the approximate resource-allocation problem. This extension of the resource-allocation problem provides a framework for analyzing decision making in contexts where one relies on approximations of the utility functions. Fairness is a typical example of such a context due to its inherently subjective nature. We show that the scheme has “optimal” properties for a large class of approximate utility functions. Furthermore, we provide a tight bound on the utility loss for this scheme. We then present a unified approach to crew rostering. This approach integrates our proposed fairness scheme with a novel mathematical formulation for crew rostering. We call the resulting problem the Fairness-Oriented Crew Rostering Problem and develop a dedicated exact Branch-Price-and-Cut solution method. We conclude by applying our solution approach to practical instances from Netherlands Railways, the largest passenger railway operator in the Netherlands. Our computational results confirm the importance of taking the fairness–attractiveness trade-off into account. This paper was accepted by Yinyu Ye, optimization.
Orthogonalizing the control of frequency combs for optical clockworks
Authors: Bourbeau Hébert Nicolas , Scholten Sarah K. , Hilton Ashby P. , Offer Rachel F. , Perrella Christopher , Luiten Andre N. 
Published: September 2021

Frequency combs play a crucial supporting role for optical clocks by allowing coherent frequency division of their output signals into the electronic domain. This task requires stabilization of the comb’s offset frequency and of an optical comb mode to the clock laser. However, the two actuators used to control these quantities often influence both degrees of freedom simultaneously. This non-orthogonality leads to artificial limits to the control bandwidth and unwanted noise in the comb. Here, we orthogonalize the two feedback loops with a linear combination of the measured signals in a field-programmable gate array. We demonstrate this idea using a fiber frequency comb stabilized to a clock laser at 259 THz, half the frequency of the

1

S

0

→

3

P

0

Yb transition. The decrease in coupling between the loops reduces the comb’s optical phase noise by 20 dB. This approach could improve the performance of any comb stabilized to any optical frequency standard.
Dynamic mitigation of nonlinear effects in a silicon photonic add-drop filter
Authors: Petrini Matteo , Milanizadeh Maziyar , Morichetti Francesco , Melloni Andrea 
Published: September 2021

Nonlinear effects limit the maximum amount of optical power that can be handled by silicon photonic integrated circuits (PICs). This limitation is particularly tight in resonant devices such as microring resonator (MRR) filters, suffering from a power-dependent resonance spread due to intracavity power enhancement. In this Letter, we present an automatic control system that can dynamically mitigate the nonlinear spectral distortion of silicon MRR filters by thermally controlling each MRR. The benefit of the proposed scheme is demonstrated on the spectral response of a polarization-transparent coupled-MRR filter operating on a 200 Gbit/s signal. The proposed technique, which does not require a priori information on the PIC topology and functionality, is scalable to more complex architectures and can be employed to compensate for generic nonlinear effects in different photonic platforms.
Enhanced light extraction of the deep-ultraviolet micro-LED via rational design of chip sidewall
Authors: Tian Meng , Yu Huabin , Memon Muhammad Hunain , Xing Zhanyong , Huang Chen , Jia Hongfeng , Zhang Haochen , Wang Danhao , Fang Shi , Sun Haiding 
Published: September 2021

In this Letter, we perform a comprehensive investigation on the optical characterization of micro-sized deep-ultraviolet (DUV) LEDs (micro-LEDs) emitting below 280 nm, highlighting the light extraction behavior in relation to the design of chip sidewall angle. We found that the micro-LEDs with a smaller inclined chip sidewall angle (

∼

33

∘

) have improved external quantum efficiency (EQE) performance 19% more than that of the micro-LEDs with a larger angle (

∼

75

∘

). Most importantly, the EQE improvement by adopting an inclined sidewall can be more outstanding as the diameter of the LED chip reduces from 40 to 20

μ

m

. The enhanced EQE of the micro-LEDs with smaller inclined chip sidewall angles can be attributed to the stronger reflection of the inclined sidewall, leading to enhanced light extraction efficiency (LEE). In the end, the numerical optical modeling further reveals and verifies the impact of the sidewall angles on the LEE of the micro-LEDs, corroborating our experiment results. This Letter provides a fundamental understanding of the light extraction behavior with optimized chip geometry to design and fabricate highly efficient micro-LEDs in a DUV spectrum of the future.
Community engagement in the prevention and control of COVID-19: Insights from Vietnam
Authors: Ha Bui Thi Thu , Ngoc Quang La , Quoc Thanh Pham , Duc Duong Minh , Mirzoev Tolib , Bui Thi My Anh 
Published: September 2021

Introduction
Community engagement (CE) is an effective public health strategy for improving health outcomes. There is limited published knowledge about effective approaches to CE in ensuring effective responses to COVID-19 throughout lockdowns, travel restrictions and social distancing. In this paper, we contribute to bridging this gap by highlighting experience of CE in Vietnam, specifically focusing on migrant workers in Vietnam.

Methods
A cross-sectional qualitative study design was used with qualitative data collection was carried out during August-October 2020. Two districts were purposefully selected from two large industrial zones. Data was collected using in-depth interviews (n = 36) with individuals and households, migrants and owners of dormitories, industrial zone factory representatives, community representatives and health authorities. Data was analyzed using thematic analysis approach. The study received ethics approval from the Hanoi University Institutional Review Board.

Results
The government’s response to COVID-19 was spearheaded by the multi-sectoral National Steering Committee for the Prevention and Control of COVID-19, chaired by the Vice Prime Minister and comprised different members from 23 ministries. This structure was replicated throughout the province and local levels and all public and private organizations. Different activities were carried out by local communities, following four key principles of infection control: early detection, isolation, quarantine and hospitalization. We found three key determinants of engagement of migrant workers with COVID-19 prevention and control: availability of resources, appropriate capacity strengthening, transparent and continuous communication and a sense of trust in government legitimacy.

Discussion and conclusion
Our results support the current literature on CE in infection control which highlights the importance of context and suggests that future CE should consider five key components: multi-sectoral collaboration with a whole-of-community approach to strengthen governance structures with context-specific partnerships; mobilization of resources and decentralization of decision making to encourage self-reliance and building of local capacity; capacity building through training and supervision to local institutions; transparent and clear communication of health risks and sensitization of local communities to improve compliance and foster trust in the government measures; and understanding the urgent needs ensuring of social security and engaging all parts of the community, specifically the vulnerable groups.
Psychometric properties and longitudinal measurement invariance of the drug craving scale: Modification of the Polish version of the Penn Alcohol Craving Scale (PACS)
Authors: Opozda-Suder Sylwia , Karteczka-Świętek Kinga , Piasecka Małgorzata 
Published: September 2021

BackgroundThe Penn Alcohol Craving Scale (PACS) is an instrument with good psychometric properties that is widely used to assess alcohol craving. Based on the assumption that the experience of craving is independent of substance type, the Polish version of the PACS was modified to measure drug craving, thus creating the Penn Drug Craving Scale (PDCS). The analyses presented in the paper aim to verify the hypothesis that the PDCS has a unidimensional structure, is highly reliable and features longitudinal measurement invariance.MethodsThe research was conducted in 14 inpatient and 13 outpatient randomly selected facilities that provide psychosocial therapy to people with substance use disorder (SUD) in Poland, during June 2018 –July 2019. The data used for the analyses came from 282 patients diagnosed on the basis of ICD-10 criteria (F11.2-F19.2). The paper presents analyses with the application of: [1] confirmatory factor analysis (CFA) conducted on the basis of a polychoric correlation matrix and the WLSMV estimator; [2] a reliability estimate using Cronbach’s alpha and coefficient omega; [3] verification of longitudinal measurement invariance between the beginning and end of therapy; [4] evaluation of criterion validity; [5] normalisation of the raw scores.ResultsThe CFA results confirmed a unidimensional PDCS structure (RMSEA = 0.047, 95% CI: 0.000–0.103; CFI = 0.999; TLI = 0.999) and a high reliability of the scale (ω = 0.93). Moreover, a strict longitudinal measurement invariance of the instrument was confirmed.ConclusionsAccurate assessment of craving is possible only with valid and reliable instruments. Therefore, the psychometric properties of the PDCS were verified based on the latest statistical approaches. The scale is a valid and highly reliable tool featuring longitudinal measurement invariance and can be usefully used for research and clinical purposes. Thus, the Polish version of the PACS has been modified and successfully applied to the population of people with SUD.
Analysis of electric cigarette liquid effect on mouse brain tumor growth through EGFR and ERK activation
Authors: Kwon Hyung Joon , Oh Young Taek , Park Saewhan , Kim Sung Soo , Park Jinju , Yin Jinlong , Hong Jun Hee , Kim Chan Il , Ryu Haseo , Park Jong Bae , Lim Min Kyung 
Published: September 2021

Introduction
Recently, electric cigarettes with liquid (e-liquid) were introduced as an alternative to tobacco smoking. They were promoted as possible cessation aids and were considered to be potentially less harmful than traditional tobacco-based cigarettes. However, there is little information on the toxicants present in e-liquids and their possible carcinogenic effects.

Methods
Western blot analysis was performed to identify the protein levels of cancer progression related signal transducers. Patient-derived brain tumor cells (CSC2) were injected into mouse brains and tumor growth was then observed by performing magnetic resonance imaging (MRI) and hematoxylin and eosin (H&E) staining of the whole brain. Immunohistochemistry (IHC) staining and Immunofluorescence staining were performed to study the expression of pEGFR and pERK.

Results
Western blotting revealed that e-liquids increased pEGFR and pERK expression in a dose dependent manner. Animal experiments revealed that the e-liquid treated group had accelerated tumor growth and poor prognosis compared to the vehicle group. Histological staining showed activation of pEGFR and pERK in the e-liquid treated group.

Conclusion
Our study revealed that e-liquid activates pEGFR and pERK, leading to accelerated brain tumor growth and poor prognosis.
Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?
Authors: Minenkova Anastasia , Jansen Erwin E. W. , Cameron Jessie , Barto Rob , Hurd Thomas , MacNeil Lauren , Salomons Gajja S. , Mercimek-Andrews Saadet 
Published: September 2021

BackgroundPyridoxine-dependent epilepsy (PDE) is due to biallelic variants inALDH7A1(PDE-ALDH7A1).ALDH7A1encodes α-aminoadipic semialdehyde dehydrogenase in lysine catabolism. We investigated the gamma aminobutyric acid (GABA) metabolism and energy production pathways in human PDE-ALDH7A1and its knock-outaldh7a1zebrafish model.MethodsWe measured GABA pathway, and tricarboxylic acid cycle metabolites and electron transport chain activities in patients with PDE-ALDH7A1and in knock-outaldh7a1zebrafish.ResultsWe report results of three patients with PDE-ALDH7A1: low paired complex I+II and complex II+III and individual complex IV activities in muscle biopsy in patient 1 (likely more severe phenotype); significantly elevated CSF glutamate in the GABA pathway and elevated CSF citrate, succinate, isocitrate and α-ketoglutarate in the TCA cycle in patient 3 (likely more severe phenotype); and normal CSF GABA pathway and TCA cycle metabolites on long-term pyridoxine therapy in patient 2 (likely milder phenotype). All GABA pathway metabolites (γ-hydroxybutyrate, glutamine, glutamate, total GABA, succinic semialdehyde) and TCA cycle metabolites (citrate, malate, fumarate, isocitrate, lactate) were significantly low in the homozygous knock-outaldh7a1zebrafish compared to the wildtype zebrafish. Homozygous knock-outaldh7a1zebrafish had decreased electron transport chain enzyme activities compared to wildtype zebrafish.DiscussionWe report impaired electron transport chain function, accumulation of glutamate in the central nervous system and TCA cycle dysfunction in human PDE-ALDH7A1and abnormal GABA pathway, TCA cycle and electron transport chain in knock-outaldh7a1zebrafish. Central nervous system glutamate toxicity and impaired energy production may play important roles in the disease neuropathogenesis and severity in human PDE-ALDH7A1.
Improved Evaluation of The Wind Power Potential of a Large Offshore Wind Farm Using Four Analytical Wake Models
Authors: Hassoine Mohammed Amine , Lahlou Fouad , Addaim Adnane , Madi Abdessalam Ait 
Published: September 2021

The objective of this paper is to investigate the ability of analytical wake models to estimate the wake effects between wind turbines (WTs). The interaction of multiple wakes reduces the total power output produced by a large offshore wind farm (LOFWF). This power loss is due to the effect of turbine spacing (WTS), if the WTs are too close, the power loss is very significant. Therefore, the optimization of turbine positions within the offshore wind farm requires an understanding of the interaction of wakes inside the wind farm. To better understand the wake effect, the Horns Rev 1 offshore wind farm has been studied with four wake models, Jensen, Larsen, Ishihara, and Frandsen. A comparative study of the wake models has been performed in several situations and configurations, single and multiple wakes are taken into consideration. Results from the Horns Rev1 offshore wind farm case have been evaluated and compared to observational data, and also with the previous studies. The power output of a row of WTs is sensitive to the wind direction. For example, if a row of ten turbines is aligned with the 270° wind direction, the full wake condition of WTs is reached and the power deficit limit predicted by Jensen model exceeds 70%. When a wind direction changes only of 10° (260° and 280°), the deficit limit reduces to 30%. The obtained results show that a significant power deficit occurs when the turbines are arranged in an aligned manner. The findings also showed that all four models gave acceptable predictions of the total power output. The comparison between the calculated and reported power output of Horns Revs 1 showed that the differences ranged from - 8.27 MW (12.49%) to 15.27 MW (23.06%) for the Larsen and Frandsen models, respectively.
Probabilistic model predictive control for extended prediction horizons
Authors: Brüdigam Tim , Teutsch Johannes , Wollherr Dirk , Leibold Marion , Buss Martin 
Published: September 2021

Abstract
Detailed prediction models with robust constraints and small sampling times in Model Predictive Control yield conservative behavior and large computational effort, especially for longer prediction horizons. Here, we extend and combine previous Model Predictive Control methods that account for prediction uncertainty and reduce computational complexity. The proposed method uses robust constraints on a detailed model for short-term predictions, while probabilistic constraints are employed on a simplified model with increased sampling time for long-term predictions. The underlying methods are introduced before presenting the proposed Model Predictive Control approach. The advantages of the proposed method are shown in a mobile robot simulation example.
Constrained stochastic predictive control of linear systems with uncertain communication
Authors: Hahn Jannik , Stursberg Olaf 
Published: September 2021

Abstract
This paper proposes a scheme of model predictive control for single-loop networked control system (NCS) with probabilistically modeled communication channel and disturbances. Uncertainties of the communication network are projected onto a tailored probability for the satisfaction of state and input constraints. The proposed receding horizon control scheme uses a probabilistic terminal state and set to establish a balance between control performance and state probability distribution, while satisfying the given constraints. In addition to describing the control approach, its properties are discussed, and it is illustrated by an example.
Flachheitsbasierte Trajektorienfolgeregelung von Flachwasserwellen in einer Röhre mit bewegtem Kolben
Authors: Wurm Jens , Woittennek Frank 
Published: September 2021

Zusammenfassung
Der Beitrag behandelt die Folgeregelung von Flachwasserwellen in einer partiell gefüllten Röhre, in der der Flüssigkeitspegel durch einen beweglichen Kolben variiert werden kann. Zur Beschreibung der Flachwasserwellen werden die Saint-Venant-Gleichungen in Euler-Koordinaten verwendet, ein quasilineares hyperbolisches Differentialgleichungssystem zweiter Ordnung. Der Beitrag fasst bereits in Vorarbeiten erzielte Ergebnisse zur Flachheit und zum darauf basierenden Steuerungsentwurf zusammen und erweitert diese Resultate um eine einfache auf den linearisierten Modellgleichungen beruhende flachheitsbasierten Folgeregelung. Die Leistungsfähigkeit der entworfene Folgeregelung wird anhand von Simulationen und experimentellen Studien nachgewiesen.