bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovering new interaction between genes in extrahepatic Cholangiocarcinoma using Bayesian networks
Authors: Salboukh Fatemeh , Jahanimoghadam Aria , Mousavi Yashar 
Published: February 2025

Abstract
Extrahepatic Cholangiocarcinoma (eCCA) is one of the most severe cancers, owing to ineffective therapeutics and resistance to treatments. There has been a lack of knowledge on the pathogenesis of eCCA, which necessitates the investigation of fine biomarkers and the discovery of targeted therapies. Bayesian networks (BNs) are known as impactful tools for dissecting gene-gene interaction in complex biological networks. Initially, we identified differentially expressed genes in eCCA using the GSE132305 dataset from GEO. eCCA-related genes were obtained separately from DisGeNET. The overlap of these two gene sets resulted in a robust minimal gene list with known roles in eCCA. We then proceeded to select the highest up-and down-regulated genes to combine them with the overlapped genes. This led us to the final dataset which was later used as the input for “bnlearn” R package to generate BNs. Investigation of the generated BNs, led to the detection of candidate genes being connected to the parent nodes, namely APOC1, PIGR, FOSB, RPS6, FGA, CTSE, and ITIH2. Further literature review revealed that out of seven candidate genes, only two (FOSB and FGA) had been reported previously in the context of cholangiocarcinoma. The other five (APOC1, PIGR, RPS6, CTSE and ITIH2) have not been reported to have any roles in eCCA. Our results can potentially be the foundation for designing new studies on the mentioned genes to delve into the molecular mechanism behind the pathogenesis of eCCA and the discovery of novel drug targets. This study emphasizes the power of BNs combined with bioinformatics tools to unlock new avenues in the understanding and treatment of complex diseases such as eCCA.
Investigation of welded joints on a medium-manganese steel for use under cryogenic conditions as an alternative to 9% Ni steels
Authors: Reppin Christoph , Treutler Kai , Brätz Oliver , Gericke Andreas , Henkel Knuth-Michael 
Published: February 2025

Abstract
The importance of technical gases has been increasing worldwide for several years. Liquefied natural gas for shipping and land-based transport are becoming increasingly important, especially as a result of political requirements to reduce emissions and climate targets. The significantly increased storage efficiency due to lower volumes means that transport and storage are mainly carried out in a cryogenic condition. However, these conditions imply special requirements for the materials used. In recent years, the 9% Ni steel has been increasingly used for cryogenic applications. This is due to the significantly higher strength properties and the resulting mass reduction compared with cold-tough high-nickel austenitic steels. In addition to the comparatively low strength of high-nickel austenites, the higher prices and susceptibility to raw material market-based price fluctuations make the materials economically unattractive for use with high material requirements. The increased requirements of liquid hydrogen storage for low-temperature toughness are pushing the conventional low-temperature materials used to their limits. For the qualification of medium manganese austenites for the maritime applications, the welding processing of an X2CrMnNiN17-7–5 is investigated and compared with results of the 9% Ni steel.
Neurodiversity: A Behavior Analyst’s Perspective
Authors: Nicolosi Michael , Dillenburger Karola 
Published: February 2025

Abstract
A neurodiversity movement (NDM) has gained momentum, mainly driven by autistic self-advocates. The main argument of the NDM is that neurodivergent people experience discrimination that is on par with the historical discrimination of other minority groups. In this article, we propose a behavior analyst’s perspective on the NDM. We first explore the history and emergence of the concept of neurodiversity and its neurological as well as psychological basis. We consider its potential for generating what some consider a zero-sum game, in which one group makes all the gains potentially at the expense of another group. We finish with the suggestion that a win–win situation is possible if the focus shifts proactively to advocacy for all persons with autism, including those with very high support needs who often are not able to advocate actively for themselves and who tend to benefit greatly from evidence-based behavior-analytic interventions.
Spectroscopy on superconductor surface modulated by periodic nanostructures
Authors: Yu Qiaoyan , Liu Yufeng , Yang Yi , Liu Dang , Xue Shasha , Chen Xingsen , Xi Ruijun , Sun Jice , Du Xian , Zhang Yi , Ning Xuhui , Miao Tingwen , Hu Pengyu , Luo Weidong , Yang Hao , Guan Dandan , Liu Xiaoxue , Liu Liang , Li Yaoyi , Wang Shiyong , Liu Canhua , Zheng Hao , Jia Jinfeng 
Published: February 2025

Abstract
Superconductors covered with periodic superstructures have attracted enormous research attention recently. However, most studies focus on the superstructures with periodicity longer than the superconductor coherence length. Here, we investigate the vacuum-cleaved 2H-NbSe2 by scanning tunneling microscopy and spectroscopy. We reveal single-layer-high periodic nanostructures on the 2H-NbSe2 surface, which arranges in about 15 nm period, i.e. similar to the coherence length of 2H-NbSe2. Our position-dependent tunneling spectroscopy uncovers that the superconductivity at zero magnetic field is only marginally affected by the nanostructure, but the vortex shape is drastically altered. Our results establish the foundation for further research on nanostructures on superconductors.
It Was Never About the Snakes: Synanon, Cult, and the Devil in Religious Studies
Authors: Logan Dana 
Published: February 2025

AbstractAgainst historians of religion who have argued that “cult” is just a term for a religion that people do not like, this article argues that “cult” has historical definitions in addition to its normative dimensions. The term’s meaning as a group that “brainwashes” stems in part from the post–World War II rise of groups that blend religion and recovery, and which are promoted by the American judicial system and federal dollars. Synanon, a group that originated the American model of a drug treatment center, allows us a unique entry point into this reassessment. Synanon argued that addiction, as just one of many “life-controlling issues,” required mutual discipline and containment. The article affirms members’ and critics’ description of the group as a cult that incarcerated its members and designed rituals to hurt them. Because of Synanon’s unique relationship to state-sponsored drug rehab, these conditions are not unique to the group. Further, the author’s affirmation of her subjects’ language cannot be separated from the normative valence of “cult.” Counter to the arguments of scholars such as J.Z. Smith, David Chidester, and Robert Orsi, scholars need to do more than describe when religions hurt people. We can also, through historical work, name when religion is designed to abuse, incarcerate, and experiment on people.
Morphology and molecular characterization of a new species of Tereancistrum parasite from the gills of Brycon nattereri
Authors: Hasuike W.T. , Scorsim B. , Arjona I.S. , Amaral R.B. , Damacena-Silva L. , Araújo G.A. , Bellay S. , de Oliveira A.V. , Takemoto R.M. 
Published: February 2025

Abstract
A new species of Tereancistrum Kritsky, Thatcher & Kayton, 1980, collected from the gills of Brycon nattereri (Bryconidae) in the Cerrado, in the state of Goiás, Brazil, is described based on morphological and molecular data, based on the mitochondrial cytochrome c oxidase subunit 1 (COI) gene region. Tereancistrum campanum n. sp. is distinguished from all its congeners by the unique ‘bell-shaped’ accessory piece in the male copulatory complex. Molecular analysis revealed that the specimens analyzed formed a distinct group from other Tereancistrum sequences and that the sequences of Tereancistrum kerri showed genetic divergence when compared to T. campanum n. sp., confirming the molecular distinction between the two species. This study also expands the knowledge of parasitic diversity in the Tocantins-Araguaia River Basin and extends the geographical distribution of the genus Tereancistrum. The combination of morphological and genetic data was essential for delimiting this new species, highlighting the importance of integrative approaches in understanding the diversity of monogeneans in freshwater fish in Brazil.
Major life events as drivers of perceived linguistic change across adulthood
Authors: Wirtz Mason A. , Pickl Simon 
Published: February 2025

Abstract
This article is the first to quantify the interindividual effects of different major life events (MLEs) on retrospective perceptions of individual-level linguistic change across the adult lifespan. In this cross-sectional study, 701 German-speaking participants from Austria completed an online survey measuring the extent to which MLEs in the educational, occupational, and personal domain are associated with perceived changes in productive and affective-attitudinal aspects of the sociolinguistic repertoire. Bayesian modeling revealed that events such as beginning a tertiary degree, entry into the workforce, and retirement were perceived to impact participants’ varietal use. Overall, however, affective-attitudinal factors such as dialect identity appear to be more readily susceptible to perceived MLE-related change. These results help pave a new path for variationist agendas that approach lifespan linguistic change not as a result of chronological age, but rather as a phenomenon influenced by individual experiential factors complexly intertwined with the process of aging.
Language switch costs in sentence comprehension between Chinese and English: Evidence from self-paced reading
Authors: Zhu Mengyan , Sturt Patrick , Damian Markus 
Published: February 2025

Abstract
Effects of language switching in bilinguals have been extensively investigated, but the majority of studies have focused on switching in language production. Here we explored intrasentential switching between Chinese and English, employing a self-paced reading paradigm, with Chinese/English using radically different orthographic systems. In addition, we investigated whether L2 (English) proficiency influences switch costs. Results revealed that switch costs emerged only when switching into L1 (Chinese); by contrast, when switching into L2, a less reliable facilitatory effect was observed. L2 proficiency affected reading speed for English stimuli, but it did not directly modulate switch costs. Moreover, we have integrated various findings from previous research and identified that the use of different comparison patterns is a major contributing factor to the inconsistency in results among prior studies. We suggest that in cross-script language switching, switch costs stem from a general cognitive control mechanism rather than from activation within the bilingual mental lexicon.
On Censorship, Silence, and Rubble: Reflections on the Destruction of a Performance Venue in Mexico City
Authors: GREEN ANDREW J. 
Published: February 2025

Abstract
This article reflects on a little-told story of musical and cultural censorship: the Mexican government's 1996 destruction of the Foro Abierto, a 2,000-seater auditorium in the heart of Chapultepec Park in Mexico City. The Foro Abierto was the home of an anarchist theatre group called CLETA, and was an important venue for a number of genre-crossing musicians. This venue was destroyed by the police just before CLETA was to inaugurate it as part of the rebel Zapatista movement. Several days later, a musician from CLETA was assassinated. Responding to the material turn in music studies, this article combines ethnographic and archival research to explore articulations between rubble and censorship. The venue's destruction disempowered and disarticulated CLETA, to the extent that an unsettling silence emerged about this act on the site of the venue itself. Equally, constructive responses to the complexities of censorship may also emerge from acts of material and ideational de-structuration.
Great Conspiracies, Stealing Seats, and Anarchy: Senatorial Elections in Disputed States, 1892–1893
Authors: Argersinger Peter H. 
Published: February 2025

AbstractWhile scholars are revitalizing political history, they continue to neglect the formal yet dynamic institutional framework that shaped not merely the traditional subjects of election campaigns and governance but also newer concerns dealing with political participation, representation, power, legitimacy, and conflict. This article focuses on the 1893 senatorial elections in the six states where neither major party held the legislative majority on joint ballot necessary to elect a U.S. senator. This fraught situation derived from the success of the new Populist party and threatened the customary Republican control of both state politics and the U.S. Senate. By examining the previously overlooked actions and interactions of election and canvassing boards, state courts, and party committees with electoral rules, judicial norms, and legislative procedures after the general election of 1892, this article demonstrates that election outcomes were often contingent upon factors other than electoral mobilization, great issues, and popular opinion. Partisanship and the search for power produced “conspiracies” that corrupted basic electoral institutions, subverted voting results, denied rightful representation, violated democratic norms and practices, and provoked popular unrest.
A postzygotic GNA13 variant upregulates the RHOA/ROCK pathway and alters melanocyte function in a mosaic skin hypopigmentation syndrome
Authors: El Masri Rana , Iannuzzo Alberto , Kuentz Paul , Tacine Rachida , Vincent Marie , Barbarot Sébastien , Morice-Picard Fanny , Boralevi Franck , Oillarburu Naia , Mazereeuw-Hautier Juliette , Duffourd Yannis , Faivre Laurence , Sorlin Arthur , Vabres Pierre , Delon Jérôme 
Published: February 2025

Abstract
The genetic bases of mosaic pigmentation disorders have increasingly been identified, but these conditions remain poorly characterised, and their pathophysiology is unclear. Here, we report in four unrelated patients that a recurrent postzygotic mutation in GNA13 is responsible for a recognizable syndrome with hypomelanosis of Ito associated with developmental anomalies. GNA13 encodes Gα13, a subunit of αβγ heterotrimeric G proteins coupled to specific transmembrane receptors known as G-protein coupled receptors. In-depth functional investigations revealed that this R200K mutation provides a gain of function to Gα13. Mechanistically, we show that this variant hyperactivates the RHOA/ROCK signalling pathway that consequently increases actin polymerisation and myosin light chains phosphorylation, and promotes melanocytes rounding. Our results also indicate that R200K Gα13 hyperactivates the YAP signalling pathway. All these changes appear to affect cell migration and adhesion but not the proliferation. Our results suggest that hypopigmentation can result from a defect in melanosome transfer to keratinocytes due to cell shape alterations. These findings highlight the interaction between heterotrimeric G proteins and the RHOA pathway, and their role in melanocyte function.
Reduced temporal variability of cortical excitation/inhibition ratio in schizophrenia
Authors: Racz Frigyes Samuel , Farkas Kinga , Becske Melinda , Molnar Hajnalka , Fodor Zsuzsanna , Mukli Peter , Csukly Gabor 
Published: February 2025

Abstract
Altered neural excitation/inhibition (E/I) balance has long been suspected as a potential underlying cause for clinical symptoms in schizophrenia (SZ). Recent methodological advancements linking the spectral slope (β) of neurophysiological recordings – such as them electroencephalogram (EEG) – to E/I ratio provided much-needed tools to better understand this plausible relationship. Importantly, most approaches treat E/I ratio as a stationary feature in a single scaling range. On the other hand, previous research indicates that this property might change over time, as well as it can express different characteristics in low- and high-frequency regimes. In line, in this study we analyzed resting-state EEG recordings from 30 patients with SZ and 31 healthy controls (HC) and characterized E/I ratio via β separately for low- (1–4 Hz) and high- (20–45 Hz) frequency regimes in a time-resolved manner. Results from this analysis confirmed the bimodal nature of power spectra in both HC and SZ, with steeper spectral slopes in the high- compared to low-frequency ranges. We did not observe any between-group differences in stationary (i.e., time-averaged) neural signatures, however, the temporal variance of β in the 20–45 Hz regime was significantly reduced in SZ patients when compared to HC, predominantly over regions corresponding to the dorsal attention network. Furthermore, this alteration was found correlated to positive clinical symptom scores. Our study indicates that altered E/I ratio dynamics are a characteristic trait of SZ that reflect pathophysiological processes involving the parietal and occipital cortices, potentially responsible for some of the clinical features of the disorder.
Chromosome-level genome assembly for the ecologically and economically important alga Saccharina japonica
Authors: Li Xiaodong , Li Yu-Long , Zhong Chenhui , Li Jing , Su Li , Liu Jin-Xian , Pang Shaojun 
Published: February 2025

Abstract

Saccharina japonica is a major kelp species of brown algae with the highest production among aquaculture seaweeds and holds important ecological and economic value. Despite advancements in domestication, a high-quality chromosome-level genome assembly is needed to assist its genetic improvement. Previous genome assemblies of S. japonica were either on a draft-level or highly fragmented. Here, we generated a high-quality chromosome-level genome for the female sporophyte using PacBio sequencing and Hi-C. The genome is 516.11 Mb, with contig N50 length of 491.30 Kb and scaffold N50 length of 16.24 Mb, anchored into 32 pseudo-chromosomes. Repetitive elements constituted 45.07% of the genome, and 17,739 protein-coding genes were predicted, of which 82% were functionally annotated. This genome provides a crucial resource for biotechnological advances in S. japonica breeding and offers insights into the ecology and evolution of brown algae.
The power spectrum and functional connectivity characteristics of resting-state EEG in patients with generalized anxiety disorder
Authors: Wang Hangwei , Mou Shaoqi , Pei Xuedan , Zhang Xiaomei , Shen Shanhong , Zhang Jianfeng , Shen Xinhua , Shen Zhongxia 
Published: February 2025

Abstract
Recent studies have suggested a relationship between abnormal neurophysiological functions and generalized anxiety disorder (GAD). However, studies on its electrophysiological characteristics, such as its power spectrum and functional connectivity are relatively few and scattered than those on other mental disorders (e.g., depression, ADHD, etc.). The present study aims to reveal the multidimensional electrophysiological characteristics of GAD via comparative analysis of electroencephalogram (EEG) data between GAD patients and healthy controls. Specifically, resting-state EEG, with a duration of 10 min, was recorded from 98 GAD patients and 92 healthy control participants. The electrophysiological characteristics, including the power spectrum, alpha asymmetry, and functional connectivity, were extracted and compared between the two groups. The results revealed significantly increased beta-band activity; decreased ipsilateral fronto-temporal and parieto-temporal functional connectivities in the lower frequency bands (theta–beta band); as well as decreased frontal‒parietal and frontal‒occipital connectivities in the higher frequency bands (beta‒gamma band) in GAD patients. Additionally, alpha asymmetry analysis revealed a significantly greater rightward temporal alpha asymmetry in GAD patients. These findings suggest the existence of significant EEG characteristics in patients with GAD, supporting previous conclusions regarding abnormal neurophysiological functions in psychiatric disorders and potentially leading to the identification of biomarkers for clinical diagnosis.
Chronic Dizziness and Positional Symptoms: An Exploration of Symptom Clusters and Participant-Reported Experiences
Authors: Hollins Brandy L. , Piker Erin G. , McCaslin Devin L. , Kush Joseph M. , Mathiassen Joachim , Huijnen Jos 
Published: February 2025

Purpose:
This mixed-methods design (a) quantitatively describes the symptom cluster assignments of patients with chronic dizziness who completed a dizziness triage questionnaire and (b) qualitatively explains patient-reported themes associated with the most frequently assigned symptom cluster.

Method:
A retrospective hybrid explanatory mixed-methods design was implemented to examine an artificial intelligence dizziness triage questionnaire posted online in a vestibular disorders support group from June 2021 to November 2022. Symptom cluster assignments are described in 791 participants. In the qualitative analysis, emerging codes were identified in the dominant symptom cluster in 50 participants.

Results:
Quantitative analysis identified a total of 301 symptom cluster combinations. The analysis from 791 participants revealed that females exhibited more symptom clusters than males, age impacted symptoms inversely, and longer duration of symptom history exhibited more symptom clusters. “Positional” was the most common symptom cluster among 50 participants. Of those 50, six major themes emerged from the data: (a) physical symptoms, (b) cognitive symptoms, (c) triggers, (d) temporal information, (e) management, and (f) emotions.

Conclusions:
The results from this study emphasize the complexity and variability of chronic dizziness. Comprehensive patient assessments that combine questionnaires with clinical expertise and patient dialogue are needed to improve diagnosis and management.
The Configuration of Hearing Loss Simulation Modulates Mismatch Responses and Discrimination to Mandarin Lexical Tone Contrasts
Authors: Cheng Ying-Ying , Lee Chia-Ying 
Published: February 2025

Purpose:
Objective measures of auditory capacity in the hearing loss population are crucial for cross-checking behavioral measures. Mismatch negativity (MMN) is an auditory event-related potential component indexing automatic change detection and reflecting speech discrimination performance. MMN can potentially serve as an objective measure of speech discrimination. This study examined whether the audibility of stimuli modulates MMN to Mandarin lexical tone contrasts by analyzing hearing loss simulation (HLS) in adults with normal hearing.

Method:

The configurations of HLS were the between-subjects variable, with the sloping HLS simulating high-frequency hearing loss (more severe hearing loss at frequencies > 1000 Hz) and the rising HLS simulating low-frequency hearing loss. An AX discrimination task was used to measure the lexical tone discrimination by calculating
d
′. A multideviant oddball paradigm with large (high-level vs. low-dipping tones, T1–T3) and small (high-rising vs. low-dipping tones, T2–T3) deviant contrasts was employed to examine whether deviant size affects MMN sensitivity to stimuli's audibility.

Results:
The results showed that the T1–T3 change elicited MMN in the sloping and rising HLS groups. The T2–T3 change elicited MMN in the sloping HLS group but a positive mismatch response in the rising HLS group. Furthermore, regression analysis indicates that more negative mismatch responses to T2–T3 predict better performance in discriminating T2–T3 contrasts.

Conclusions:
MMN to the T2–T3 change is sensitive to reduced audibility at frequencies lower than 1000 Hz. This suggests that MMN has the potential to serve as an objective assessment for evaluating lexical tone discrimination in people with hearing loss.