bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERSEPSI ANAK USIA DINI TERHADAP BENTUK MAKANAN UNIK
Authors: Farida Arinie Soelistianto  , Martono Dwi Atmadja  , Kristina Widjajanti  , Yani Ratnawati  , Azam Muzakhim Imammuddin  
Published: April 2021

Nutrient content and efficacy of the oyster mushroom has a high protein with a complete amino acids, including essential amino acids needed manusia.Selain itutuna oyster contains vitamins B1, B2 and some mineral salts of the elements Ca, P, Fe, Na and K . The fiber content of 7.4% until the mushrooms start of 27.6% is very good for digestion. While the meatballs are generally the typical food of the city of Malang are usually made from raw material although recent beef can also be made from raw materials of fish, chicken and mushroom.
Apart easily cultivated oyster mushrooms also are cheap and plentiful and can be purchased at any place. Communities with lower economic levels can utilize adequate nutrition by consuming the mushrooms. Making meatballs from the basic ingredients of oyster mushrooms are also very easy to manufacture so diharapkakn could be an alternative to improve nutrition can also be developed to increase revenues when produced as meatballs mushrooms.
Pre-test results showed that before the training participants still do not understand about the material with a mean value of 1.92. After carrying out training post test mean value becomes 3.75 This means participants' understanding of the material provided increased 98.5135%. This shows that the community service activities managed to improve the knowledge and skills of participants in the process recipe meatballs made from fresh oyster mushrooms.
BIMBINGAN DAN PELATIHAN IMPLEMENTASI KEPEMIMPINAN UNTUK PEMBERDAYAAN IBU-IBU PKK RW 03 KELURAHAN KETAWANG GEDE KOTA MALANG
Authors: Masreviastuti  , Mahmudatul Himmah  , Helmy Adisaksana  , Lilies Nur Aini  , Fauziah  
Published: April 2021

To create harmonious living conditions, group members must respect and appreciate each other. Humans are endowed with the ability to think, the ability to sort & choose what is good & what is bad. With these advantages, humans should be able to manage the environment well. Not only should the environment be managed properly, human social life also needs to be managed properly. For that we need quality human resources. A resource with a leadership spirit, at least to lead himself. In RW 03, Ketawang Gede Village, the number of PKK members consists of 30 mothers with 90% professions: entrepreneurs, 10% private employees and civil servants aged between 25 - 50 years where they always need to do independent and team work.
With the spirit of a human leader, he will be able to manage himself, the group & the environment well. Especially in dealing with problems that are relatively complicated & difficult, so a leader is required to be wise in making decisions so that problems can be resolved properly.
Host-Specific Serum Factors Control the Development and Survival of Schistosoma mansoni
Authors: Anisuzzaman  , Frahm Sören , Prodjinotho Ulrich Fabien , Bhattacharjee Sonakshi , Verschoor Admar , Prazeres da Costa Clarissa 
Published: April 2021

IntroductionSchistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage ofSchistosoma mansoni, into adult worms. This natural course of infection can be mimicked in experimental mouse models of schistosomiasis. However, only a maximum of 20-30% of penetrated cercariae mature into fecund adults. The reasons for this are unknown but could potentially involve soluble factors of the innate immune system, such as complement factors and preexisting, natural antibodies.Materials and MethodsUsing our recently developed novel serum- and cell-freein vitroculture system for newly transformed schistosomula (NTS), which supports long-term larval survival, we investigated the effects of mouse serum and its major soluble complement factors C1q, C3, C4 as well as preexisting, natural IgMin vitroand assessed worm developmentin vivoby infecting complement and soluble (s)IgM-deficient animals.ResultsIn contrast to sera from humans and a broad variety of mammalian species, serum from mice, surprisingly, killed parasites already at skin stagein vitro. Interestingly, the most efficient killing component(s) were heat-labile but did not include important members of the perhaps best known family of heat-labile serum factors, the complement system, nor consisted of complement-activating natural immunoglobulins. Infection of complement C1q and sIgM-deficient mice withS. mansonias well asin vitrotests with sera from mice deficient in C3 and C4 revealed no major role for these soluble factorsin vivoin regard to parasite maturation, fecundity and associated immunopathology. Rather, the reduction of parasite maturation from cercariae to adult worms was comparable to wild-type mice.ConclusionThis study reveals that not yet identified heat-labile serum factors are major selective determinants of the host-specificity of schistosomiasis, by directly controlling schistosomal development and survival.
SOLTI-1805 TOT-HER3 Study Concept: A Window-of-Opportunity Trial of Patritumab Deruxtecan, a HER3 Directed Antibody Drug Conjugate, in Patients With Early Breast Cancer
Authors: Pascual Tomás , Oliveira Mafalda , Ciruelos Eva , Bellet Ezquerra Meritxell , Saura Cristina , Gavilá Joaquin , Pernas Sonia , Muñoz Montserrat , Vidal Maria J. , Margelí Vila Mireia , Cejalvo Juan M. , González-Farré Blanca , Espinosa-Bravo Martin , Cruz Josefina , Salvador-Bofill Francisco Javier , Guerra Juan Antonio , Luna Barrera Ana María , Arumi de Dios Miriam , Esker Stephen , Fan Pang-Dian , Martínez-Sáez Olga , Villacampa Guillermo , Paré Laia , Ferrero-Cafiero Juan M. , Villagrasa Patricia , Prat Aleix 
Published: April 2021

Background: Preclinical data support a key role for the human epidermal growth factor receptor 3 (HER3) pathway in hormone receptor (HR)–positive breast cancer. Recently, new HER3 directed antibody drug conjugates have shown activity in breast cancer. Given the need to better understand the molecular biology, tumor microenvironment, and mechanisms of drug resistance in breast cancer, we designed this window-of-opportunity study with the HER3 directed antibody drug conjugate patritumab deruxtecan (HER3-DXd; U3-1402).Trial Design: Based on these data, a prospective, multicenter, single-arm, window-of-opportunity study was designed to evaluate the biological effect of patritumab deruxtecan in the treatment of naïve patients with HR-positive/HER2-negative early breast cancer whose primary tumors are ≥1 cm by ultrasound evaluation. Patients will be enrolled in four cohorts according to the mRNA-based ERBB3 expression by central assessment. The primary endpoint is a CelTIL score after one single dose. A translational research plan is also included to provide biological information and to evaluate secondary and exploratory objectives of the study.Trial Registration Number: EudraCT 2019-004964-23; NCT number: NCT04610528.
Impact of Time to Castration Resistance on Survival in Metastatic Hormone Sensitive Prostate Cancer Patients in the Era of Combination Therapies
Authors: Wenzel Mike , Preisser Felix , Hoeh Benedikt , Schroeder Maria , Würnschimmel Christoph , Steuber Thomas , Heinzer Hans , Banek Severine , Ahrens Marit , Becker Andreas , Karakiewicz Pierre I. , Chun Felix K. H. , Kluth Luis A. , Mandel Philipp 
Published: April 2021

BackgroundTo evaluate the impact of time to castration resistance (TTCR) in metastatic hormone-sensitive prostate cancer (mHSPC) patients on overall survival (OS) in the era of combination therapies for mHSPC.Material and MethodsOf 213 mHSPC patients diagnosed between 01/2013-12/2020 who subsequently developed metastatic castration resistant prostate cancer (mCRPC), 204 eligible patients were analyzed after having applied exclusion criteria. mHSPC patients were classified into TTCR &lt;12, 12-18, 18-24, and &gt;24 months and analyzed regarding OS. Moreover, further OS analyses were performed after having developed mCRPC status according to TTCR. Logistic regression models predicted the value of TTCR on OS.ResultsMedian follow-up was 34 months. Among 204 mHSPC patients, 41.2% harbored TTCR &lt;12 months, 18.1% for 12-18 months, 15.2% for 18-24 months, and 25.5% for &gt;24 months. Median age was 67 years and median PSA at prostate cancer diagnosis was 61 ng/ml. No differences in patient characteristics were observed (all p&gt;0.05). According to OS, TTCR &lt;12 months patients had the worst OS, followed by TTCR 12-18 months, 18-24 months, and &gt;24 months, in that order (p&lt;0.001). After multivariable adjustment, a 4.07-, 3.31-, and 6.40-fold higher mortality was observed for TTCR 18-24 months, 12-18 months, and &lt;12 months patients, relative to TTCR &gt;24 months (all p&lt;0.05). Conversely, OS after development of mCRPC was not influenced by TTCR stratification (all p&gt;0.05).ConclusionPatients with TTCR &lt;12 months are at the highest OS disadvantage in mHSPC. This OS disadvantage persisted even after multivariable adjustment. Interestingly, TTCR stratified analyses did not influence OS in mCRPC patients.
Unpowered Scooter Injury in Children at a Korea Level I Trauma Center
Authors: Keum Min Ae , Cho Min Jeng 
Published: April 2021

Purpose:Unpowered scooters for recreation and transportation are popular among children. However, to date, there have been no studies on scooter-related injuries in Korea. This study aimed to assess the frequency and injury pattern with unpowered scooters and to propose prevention strategies.Methods:Medical records of children aged &lt;16 years with unpowered scooter-related injuries who visited the emergency department (ED) from 2007 to 2018 were retrospectively reviewed.Results:A total of 109 children were included. The majority (78.9%) of injuries occurred during the last 3 years of the study. The mean age was 5.2 years, and 88% of children were &lt;8 years of age. Most injuries (80.7%) occurred from a fall off a scooter. A total of 65.1% (n= 71) of injuries were to the head and face, followed by upper limb, lower limb, and torso injuries. Eight patients had an intracranial injury and skull fracture. Twenty children had limb fractures, and the most common site of fracture was the elbow. None of the patients wore any protective gear.Conclusions:Unpowered scooter-related injuries are on the increase and represent a serious problem among younger children. The head and face, where serious injuries can occur, are the most vulnerable. Public and parental awareness and education regarding protective gear and safety guidelines are essential to prevent injuries.
Implementation and Outcomes of a Telehealth Neonatology Program in a Single Healthcare System
Authors: Maddox Lory J. , Albritton Jordan , Morse Janice , Latendresse Gwen , Meek Paula , Minton Stephen 
Published: April 2021

Background: Intermountain Healthcare, an early adopter and champion for newborn video-assisted resuscitation (VAR), identified a reduction in facility-level transfers and an estimated savings of $1. 2 million in potentially avoided transfers in a 2018 study. This study was conducted to increase understanding of VAR at the individual, newborn level.Study Aim: To compare transfers to a newborn intensive care unit (NICU), length of stay (LOS), and days of life on oxygen between newborns managed by neonatal VAR and those receiving standard care (SC).Methods: This retrospective, nonequivalent group study includes infants born in an Intermountain hospital between 2013 and 2017, 34 weeks gestation or greater, and requiring oxygen support in the first 15 minutes of life. Data came from billing and clinical records from Intermountain's enterprise data warehouse and chart reviews. We used logistic regression to estimate neonatal VAR's impact on transfers. Negative binomial regression estimated the impact on LOS and days of life on supplemental oxygen.Results: The VAR intervention was used in 46.2 percent of post-implementation cases and is associated with (1) a 12 percentage points reduction in the transfer rate, p = 0.02, (2) a reduction in spoke hospital (SH) LOS of 8.33 h (p &lt; 0.01) for all transfers; (3) a reduction in SH LOS of 2.21 h (p &lt; 0.01) for newborns transferred within 24 h; (4) a reduction in SH LOS of 17.85 h (p = 0.06) among non-transferred newborns; (5) a reduction in days of life on supplemental oxygen of 1.4 days (p = 0.08) among all transferred newborns, and (6) a reduction in days of life on supplemental oxygen of 0.41 days (p = 0.04) among non-transferred newborns.Conclusion: This study provides evidence that neonatal VAR improves care quality and increases local hospitals' capabilities to keep patients close to home. There is an ongoing demand for support to rural and community hospitals for urgent newborn resuscitations, and complex, mandatory NICU transfers. Efforts may be necessary to encourage neonatal VAR since the intervention was only used in 46.2 percent of this study's potential cases. Additional work is needed to understand the short- and long-term impacts of Neonatal VAR on health outcomes.
Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury
Authors: Ma Haoyang , Liu Jiaye , Du Yang , Zhang Shengnan , Cao Weidong , Jia Zhanjun , Gong Wei , Zhang Aihua 
Published: April 2021

Sepsis-associated liver dysfunction remains a challenge in clinical practice with high mortality and limited specific therapies. DY131 is a pharmacological agonist of the orphan receptor estrogen-related receptor (ERR) γ which plays a crucial role in regulating energy generation, oxidative metabolism, cell apoptosis, inflammatory responses, etc. However, its role in acute liver injury is unknown. In this study, we evaluated the effect of DY131 on lipopolysaccharide (LPS)-induced liver injury. Mice were pretreated with DY131 through intraperitoneal injection at a dose of 5 mg/kg/day for 3 days prior to LPS challenge (10 mg/kg). 24 h later, they were anesthetized and sacrificed. Blood and liver tissues were collected for further studies. In a separate experiment, mice were treated with saline (vehicle) or DY131 for 3 days to evaluate the toxicity of DY131. We found that ERRγ was downregulated in the liver tissues from LPS-treated mice. Pretreatment with DY131 ameliorated LPS-induced liver injury as demonstrated by reduced liver enzyme release (ALT, AST, and LDH), improved liver morphological damage, and attenuated oxidative stress, inflammation and apoptosis. Meanwhile, DY131 had no significant side effects on hepatic and renal functions in mice. Finally, transcriptomics analysis revealed that the dysregulated pathways associated with inflammation and metabolism were significantly reversed by DY131 in LPS-treated mice, providing more evidence in favor of the protective effect of DY131 against LPS-induced liver injury. Altogether, these findings highlighted the protective effect of DY131 on LPS-induced hepatotoxicity possibly via suppressing oxidative stress, inflammation, and apoptosis.
Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder
Authors: Murayama Keitaro , Tomiyama Hirofumi , Tsuruta Sae , Ohono Aikana , Kang Mingi , Hasuzawa Suguru , Mizobe Taro , Kato Kenta , Togao Osamu , Hiwatashi Akio , Nakao Tomohiro 
Published: April 2021

Background: Although abnormality of cerebellar-cerebral functional connectivity at rest in obsessive-compulsive disorder (OCD) has been hypothesized, only a few studies have investigated the neural mechanism. To verify the findings of previous studies, a large sample of patients with OCD was studied because OCD shows possible heterogeneity.Methods: Forty-seven medication-free patients with OCD and 62 healthy controls (HCs) underwent resting-state functional magnetic imaging scans. Seed-based connectivity was examined to investigate differences in cerebellar-cerebral functional connectivity in OCD patients compared with HCs. Correlations between functional connectivity and the severity of obsessive-compulsive symptoms were analyzed.Results: In OCD, we found significantly increased functional connectivity between the right lobule VI and the left precuneus, which is a component of the default mode network (DMN), compared to HCs. However, there was no correlation between the connectivity of the right lobule VI-left precuneus and obsessive-compulsive severity.Conclusions: These findings suggest that altered functional connectivity between the cerebellum and DMN might cause changes in intrinsic large-scale brain networks related to the traits of OCD.
Profile of fungal keratitis in a Sub-Himalayan territory of north India
Authors: Verma Anil Kumar , Sood Anuradha , Chauhan Anil , Tuli Rajeev , Jaryal Subhash Chand 
Published: April 2021

Aim: To study the microbiological and epidemiological profile of patients with suppurative corneal ulcer presenting in a rural referral center situated in a Sub-Himalayan territory of north India. The study was conducted to evaluate the epidemiology and frequency of mycotic keratitis among the patients of suppurative corneal ulcer and to identify various fungal species as etiological agents.
Methods: Corneal scrapings from 56 patients of suppurative corneal ulcers were subjected to direct microscopy and culture.
Results: Of the 56 cases of suppurative corneal ulcer investigated, fungal etiology was identified in 18 (32%) cases. Most of the patients (82.1%) worked in agriculture. Trivial trauma with vegetative matter was the most common predisposing factor. Fusarium and Acremonium species were the most common fungi isolated, followed by Aspergillus. Four cases of rare mycotic keratitis caused by Paecilomyces lilacinus, Scedosporium apiospermum, Monilia sitophila, and Ulocladium species were detected. Four cases were smear positive (10% KOH wet mount) but culture negative. Analysis of KOH wet mount was done using culture as gold standard. The sensitivity and specificity of KOH wet mount was 71.43% and 90.48%, respectively.
Conclusion: Direct microscopy and culture has a greater diagnostic value in the management of suppurative corneal ulcer. The authors have observed changes in the pattern of organisms identified as cause of fungal keratitis in the region. Rare species of fungi may also be detected if corneal scrapings are collected for direct microscopy and culture from all the cases of suppurative corneal ulcers greater than 2 mm.
Hubungan antara Kecemasan dan Motivasi dengan Prestasi Atlet Bola Voli di Masa Pandemi Covid-19
Authors: Aep rohendi  , Budiman Ali , Cipta Mohamad Gelar 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui apakah kecemasan dan motivasi memiliki hubungan dengan prestasi atlet bola voli PBV Pasundan di masa pandemi covid-19 Metode dalam penelitian ini menggunakan metode deskriptif dengan korelasional, populasi dalam penelitian ini atlet PBV Pasundan yang berusia 19 tahun berjumlah 12 atlet, teknik sampling meggunakan purposive sampling, adapun sampel dalam penelitian ini ialah 12 orang. Instrument menggunakan angket kuisioner dengan skala likert, teknik analisis data menggunakan analisis data statistika dengan berbantuan aplikasi spss versi 24. Hasil penelitian menunjukan bahwa (1)Terdapat hubungan yang signifikan antara kecemasan dengan prestasi atlet, dengan kata lain semakin bisa ditanggulangi serta diminimalisir kecemasan setiap atlet maka akan memiliki kecenderungan dapat meningkatkan prestasi atlet itu sendiri terhadap tim. (2) Terdapat hubungan yang signifikan antara motivasi dengan prestasi atlet, dengan kata lain semakin tinggi motivasi atlet untuk berprestasi maka memiliki kecenderungan dapat meningkatkan prestasi atlet itu sendiri terhadap tim. (3) Terdapat hubungan yang signifikan antara kecemasan dan motivasi dengan prestasi atlet PBV Pasundan.
Pas de pétrole, mais de l’Auto-Tune !
Authors: Creton Caroline , Bellanger Julien 
Published: April 2021

Cher, T-Pain, Saez, Châton, Booba, Benjamin Biolay, Bon Iver, Yung Beef, Lady Gaga, Neil Young ou encore PNL, tous ces artistes ont en commun l’usage de l’Auto-Tune. Ce dernier désigne un logiciel permettant d’ajuster, de corriger la voix à la suite d’un enregistrement ou durant une performance. Si initialement, l’Auto-Tune permet de chanter juste, cela est également utilisé pour produire des modulations sonores donnant un caractère artificiel, robotique, non linéaire à la voix humaine. Le premier titre avec une présence marquée de l’Auto-Tune est « Believe » de Cher sorti en 1998 qui connaît un succès retentissant. Depuis, si quelques artistes – à l’image de Jay-Z et son titre D.O.A. pour « Death of Auto-Tune » (2009) – dénoncent cette pratique, l’Auto-Tune a conquis l’industrie musicale et serait utilisé dans la quasi-totalité des productions (Reynolds, 2019), toutes les esthétiques confondues. Malgré cette diffusion, encore peu de recherches académiques abordent cette question. Quels sont les enjeux liés à l’Auto-Tune ?
L’objet goethéen et les autres
Authors: Mosconi Muriel 
Published: April 2021

Quelle est l’incidence clinique et théorique de la typologie des objets de l’identification – objets aristotélicien, goethéen et lacanien – que Lacan amène lors de la dernière séance du séminaire « L’Identification » le 27 juin 1962 ?
Identité et signature
Authors: Meunier Anne 
Published: April 2021

À travers son histoire on verra que la signature donne au nom propre une singularité calligraphique. À travers son usage ou son non usage, alors que Michel Foucault traite de la « fonctionauteur », Lacan propose à ses élèves avec Scilicet d’écrire des choses non signées. De quoi la signature est-elle la trace ?
Le dire de l’analyse et l’identité
Authors: Leray Pascale 
Published: April 2021

Comment une analyse peut-elle dans son accomplissement délivrer au sujet son identité singulière ? Ce travail traite cette question en fondant cette identité sur le réel irréductible du symptôme du sujet. Y atteindre implique d’en dégager la lettre avec laquelle se traduit la façon dont le sujet a affaire à la jouissance opaque et hors sens de son inconscient. Cette opération, qui dégage le Un tout seul de la jouissance, requiert la mise en acte du dire dans l’analyse avec ses différents effets de coupure et de renouage, lesquels modifient le rapport du sujet à cette jouissance de son inconscient. Ce texte propose d’examiner différentes conséquences de cette modification pour le sujet dès lors qu’il consent à cet Un sinthomatique qui le singularise.
Les psychanalystes au tournant de la plaque tournante
Authors: Nguyên Albert 
Published: April 2021

Ce texte se propose d’examiner la fonction de la phobie à partir de cette phrase de Lacan extraite du compte rendu sur l’Acte analytique : « La ligne de résistance tient sur cet ouvrage démesurément avancé que peut l’être une phobie. C’est dire qu’il est désespéré de faire entendre qu’on n’a rien entendu de l’inconscient si on n’est pas allé plus loin. » Aller plus loin fait envisager la castration, la douleur d’exister, la traversée de la mort, le piège narcissique. Les conséquences éthiques du trajet, celles sur l’angoisse et le désir y seront examinées.
Mise à jour de la question de la panique et de la phobie
Authors: Nominé Bernard 
Published: April 2021

Après avoir distingué la panique des phobies au niveau de la structure, ce texte parcourt les élaborations de Lacan concernant la phobie du petit Hans, depuis le séminaire sur la relation d’objet, jusqu’au séminaire « RSI ». Il en ressort que Lacan a toujours placé la phobie au carrefour de trois registres : réel, symbolique et imaginaire. Dans ces dernières élaborations, Lacan a esquissé un nouage particulier pour la phobie qui réussit ainsi à arrimer la jouissance phallique à l’image du corps. Si ce point est naturellement délicat chez le garçon, qu’en est-il pour la petite fille ? C’est à cela que ce texte tente de répondre en examinant l’observation du cas de la petite anglaise présentée par Anneliese Schnurmann.