bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor
Authors: Ju Xuan , Wang Shengdong , Yan Pan , Zhu Chunyan , Hu Xiwen , Dong Jiezheng , Tan Zhonglin 
Published: July 2021

Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured. The efficacy of REMSD and fluoxetine on the pleasure experience, exploration, and cognition of rats with depression was determined by the Sucrose preference test, the open field test, and Morris water task, respectively. The effects of REMSD and fluoxetine on depression-induced damage and apoptosis in rat hippocampi were detected using hematoxylin–eosin staining and terminal transferase-mediated biotin 2′-deoxyuridine, 5′-triphosphate nick end labeling. A1 adenosine receptor content was measured by immunohistochemistry. Relative expressions of the A1 adenosine receptor, proteins related to apoptosis (B Bcl-2-associated X protein; B-cell lymphoma 2), phosphoinositide 3-kinase, P38 mitogen-activated protein kinase, cFos, and adenosine deaminase RNA specific two were quantified by quantitative real-time polymerase chain reaction and Western blot as needed.Results: Depression decreased rat weight. REMSD combined with fluoxetine increased body weight, prompted rat behavior, alleviated depression-induced damage, attenuated apoptosis, and promoted A1 adenosine receptor level in rat hippocampi. Furthermore, the combined therapy upregulated expressions of A1 adenosine receptor, B-cell lymphoma 2, and phosphoinositide 3-kinase but downregulated those of B-cell lymphoma 2-associated X protein, P38 mitogen-activated protein kinase, cFos, and adenosine deaminase RNA specific 2 in the hippocampi of rats with depression.Conclusion:REMSD combined with fluoxetine protected rats against depression-induced damage and apoptosis in the hippocampus via the A1 adenosine receptor, providing a possible treatment strategy for depression.
Differences Between the Psychiatric Symptoms of Healthcare Workers Quarantined at Home and in the Hospital After Contact With a Patient With Middle East Respiratory Syndrome
Authors: Seong Su Jeong , Kim Hyung Joon , Yim Kyung Mi , Park Ji Won , Son Kyung Hoon , Jeon Yeong Ju , Hwang Jae Yeon 
Published: July 2021

Objective: Although quarantine is an effective measure for the prevention of the spread of infectious diseases, it may have negative effects on the mental health of the isolated individual. During the 2015 outbreak of the Middle East Respiratory Syndrome (MERS) in Korea, healthcare workers came in contact with patients with MERS were quarantined either at home or in a hospital ward. In this study, we aimed to compare the psychiatric symptoms of these employees according to the method of quarantine.Methods: All 146 quarantined staff completed self-report questionnaires. Depressive symptoms were measured using the Patient Health Questionnaire-9, anxiety symptoms were assessed using Spielberger's State-Trait Anxiety Inventory, and acute stress disorder (ASD) symptoms were evaluated using the Stanford Acute Stress Reaction Questionnaire.Results: The in-hospital quarantine group had a higher rate of symptoms of depression (p &lt; 0.001) and ASD (p = 0.014) than the group quarantined at home. Logistic regression analysis showed that respondents quarantined in the hospital (OR = 6.342; 95% CI 1.853–21.708) and those quarantined for longer periods (OR = 1.153, 95% CI = 1.036–1.285) had a higher risk of depressive symptoms.Conclusions: In-hospital quarantine and quarantine for longer periods increase the risk of depressive symptoms. When quarantine measures are taken, certain measures are needed to minimize the risk of psychiatric problems. Appropriate interventions should be implemented if psychiatric problems occur.
Does the Internet Use Improve the Mental Health of Chinese Older Adults?
Authors: Xie Lin , Yang Hua-lei , Lin Xue-yu , Ti Shi-ming , Wu Yuan-yang , Zhang Shuo , Zhang Si-qing , Zhou Wan-li 
Published: July 2021

Purpose: The Internet has become an important part of daily life. However, older adults in China remain digital refugees amid the rapid development of digital information technology. This study attempts to scientifically answer how Internet use affects the subjective welfare of older adults.Method: Using data from the 2014 and 2016 China Longitudinal Aging Social Survey (CLASS), a combination of ordinary least squares, ordered logit regression models, and propensity score matching (PSM) models were used to analyze the effects of Internet use on the mental health of Chinese older adults.Results: Our findings suggest that Internet use affects the mental health of older adults and increases the incidence of their depressive symptoms. These findings are robust to changing the key indicators, research method, and sample. Further heterogeneity analysis reveals that the negative effects on mental health are more evident for specific groups of older adults, such as those who are women, younger and middle-aged, high-income, non-rural Hukou, less educated, and living with others.Conclusions: Cultivating the ability of older adults to use the Internet and maintain a rational attitude while doing so can prevent its negative impact on their life satisfaction. Moreover, it can improve their attitudes toward using the technology and reduce their anxiety.
Lung Cancer Segmentation With Transfer Learning: Usefulness of a Pretrained Model Constructed From an Artificial Dataset Generated Using a Generative Adversarial Network
Authors: Nishio Mizuho , Fujimoto Koji , Matsuo Hidetoshi , Muramatsu Chisako , Sakamoto Ryo , Fujita Hiroshi 
Published: July 2021

Purpose: The purpose of this study was to develop and evaluate lung cancer segmentation with a pretrained model and transfer learning. The pretrained model was constructed from an artificial dataset generated using a generative adversarial network (GAN).Materials and Methods: Three public datasets containing images of lung nodules/lung cancers were used: LUNA16 dataset, Decathlon lung dataset, and NSCLC radiogenomics. The LUNA16 dataset was used to generate an artificial dataset for lung cancer segmentation with the help of the GAN and 3D graph cut. Pretrained models were then constructed from the artificial dataset. Subsequently, the main segmentation model was constructed from the pretrained models and the Decathlon lung dataset. Finally, the NSCLC radiogenomics dataset was used to evaluate the main segmentation model. The Dice similarity coefficient (DSC) was used as a metric to evaluate the segmentation performance.Results: The mean DSC for the NSCLC radiogenomics dataset improved overall when using the pretrained models. At maximum, the mean DSC was 0.09 higher with the pretrained model than that without it.Conclusion: The proposed method comprising an artificial dataset and a pretrained model can improve lung cancer segmentation as confirmed in terms of the DSC metric. Moreover, the construction of the artificial dataset for the segmentation using the GAN and 3D graph cut was found to be feasible.
Short-Range Wireless Transmission in the 300 GHz Band Using Low-Profile Wavelength-Scaled Dielectric Cuboid Antennas
Authors: Yamada Kazuki , Samura Yuto , Minin Oleg V. , Kanno Atsushi , Sekine Norihiko , Nakajima Junichi , Minin Igor V. , Hisatake Shintaro 
Published: July 2021

A short-range terahertz (THz) wireless transmission in the 300 GHz band is demonstrated using low-profile wavelength-scaled dielectric transmitting and receiving cuboid antennas (DCAs). These dielectric cuboid antennas are made of polytetrafluoroethylene with dimensions of approximately 1.2 mm × 1.2 mm × 1.3 mm. The near-field pattern of a DCA at 300 GHz was measured using an electro-optic sensing technique, and its far-field pattern characterization was based on the near-field to far-field transformation. The measured antenna gain was 15.06 ± 0.06 dBi. By employing DCAs as transmitting and receiving antennas, a 17.5 Gbps data transmission rate at distances of approximately 200 and 50 mm with bit error rates of 3.31 × 10–3 and 7.51 × 10–7 respectively, is demonstrated. The proposed mesoscopic scale DCA is a promising antenna type in intra-device communications and Kiosk download applications for future mobile devices operating in the 300 GHz band.
Promoting Exercise and Healthy Diet Among Primary Care Patients: Feasibility, Preliminary Outcomes, and Lessons Learned From a Pilot Trial With High Intensity Interval Exercise
Authors: Smith-Ryan Abbie E. , Weaver Mark A. , Viera Anthony J. , Weinberger Morris , Blue Malia N.M. , Hirsch Katie R. 
Published: July 2021

Physical activity and healthy diet are recognized as effective approaches for disease prevention. Controlled laboratory clinical trials support these approaches, yet minimal data exists supporting implementation of exercise as medicine within a healthcare setting.Objectives: To understand perception and barriers to exercise and nutrition from patients and physicians from a family medicine clinic (FMC) to inform the implementation of a laboratory-based exercise and nutrition lifestyle intervention (Phase I), and to determine the feasibility, adherence, and preliminary outcomes of implementing this lifestyle intervention into a FMC (Phase II).Methods: In phase I 10 patients and 5 physicians were interviewed regarding perceptions of exercise and nutrition practices. In phase II patients at risk for cardiovascular disease were enrolled into a lifestyle intervention (n = 16), within a FMC, manipulating diet and exercise. Cardiorespiratory fitness (CRF), body composition, and metabolic blood markers were completed at baseline, after the 12-week intervention, and at 24 weeks. Feasibility was defined by patients who completed the intervention and number of sessions vs. total available.Results: Prescribing high-intensity interval training and a meal replacement for 12 weeks in patients with at least one risk factor for cardiovascular disease, was shown to have moderate feasibility with 62.5% (n = 10) for patients completing the 12 week intervention, and poor feasibility for assessing effects 12 weeks after cessation of the intervention, with 50% (n = 5) participants returning. Tracking exercise electronically via FitBit had moderate fidelity (n = 9), with hardcopy logs yielding poor compliance (n = 6). This pilot study demonstrated preliminary effectiveness of this home-based approach for improving cardiorespiratory fitness with an average 4.31 ± 5.67 ml·kg·min−1 increase in peak oxygen consumption. Blood triglycerides and insulin were improved in 70% and 60% of the patients, respectively.Conclusions: Despite moderate feasibility, a home-based exercise and nutrition has the potential to be used as an effective approach for managing and mitigating cardiovascular disease risk factors. There were key lessons learned which will help to develop and adapt a larger scale lifestyle intervention into a clinical setting.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/study/NCT02482922, identifier NCT02482922.
Prognostic Signature of Osteosarcoma Based on 14 Autophagy-Related Genes
Authors: Qi Wei , Yan Qian , Lv Ming , Song Delei , Wang Xianbin , Tian Kangsong 
Published: July 2021

Background:Osteosarcoma is a common malignancy of bone with inferior survival outcome. Autophagy can exert multifactorial influence on tumorigenesis and tumor progression. However, the specific function of genes related to autophagy in the prognosis of osteosarcoma patients remains unclear. Herein, we aimed to explore the association of genes related to autophagy with the survival outcome of osteosarcoma patients.Methods:The autophagy-associated genes that were related to the prognosis of osteosarcoma were optimized by LASSO Cox regression analysis. The survival of osteosarcoma patients was forecasted by multivariate Cox regression analysis. The immune infiltration status of 22 immune cell types in osteosarcoma patients with high and low risk scores was compared by using the CIBERSORT tool.Results:The risk score model constructed according to 14 autophagy-related genes (ATG4A, BAK1, BNIP3, CALCOCO2, CCL2, DAPK1, EGFR, FAS, GRID2, ITGA3, MYC, RAB33B, USP10, and WIPI1) could effectively predict the prognosis of patients with osteosarcoma. A nomogram model was established based on risk score and metastasis.Conclusion:Autophagy-related genes were identified as pivotal prognostic signatures, which could guide the clinical decision making in the treatment of osteosarcoma.
Teologia Moral Contemporânea: ética e hermenêutica em 1Jo 2,15-17
Authors: Frecheiras Marta Luzie de Oliveira 
Published: July 2021

“Teologia moral contemporânea: ética e hermenêutica em 1Jo 2,15-17” propõe uma reflexão acerca das questões morais que assolam a humanidade. Traça rotas de investigação para a compreensão da moral nos livros bíblicos, detendo-se nas Cartas Católicas – aspectos principais da primeira Epístola de João – e realiza uma análise particular da ética na hermenêutica de 1Jo 2,15-17, a fim de poder demonstrar que o papel da teologia moral católica na contemporaneidade é o de “humanizar” o ser humano, reafirmando que não há outro modelo a ser seguido a não ser Jesus Cristo.

Palavras-chave: Ética e moral; Bíblia e moral; ética religiosa; ética cristã; mundanidade.
Analisa Sistem Informasi Pemliharaan Prasarana Jalan dan Jembatan Dinas Pekerjaan Umum (PU)
Authors: Firna Yenila  , Mutiana Pratiwi  , Devia Kartika  , Rima Liana Gema  , Gustiawan Efendi  
Published: July 2021

Telah dilakukan penelitian pada Kantor Dinas Pekerjaan Umum (PU) Kabupaten Pasaman Baratdimana permasalahan yang dijadikan sebagai dasar dalam penelitian ini yaitu penyajian informasi Mengenai prasarana Jalan Dan jembatansecara cepat dan tepat. Dengan proses observasi secara langsung kelapangan telah mendapatkan kelemahan sistem yang sedang berjalan. Walaupun tidak secara keseluruhan namun lebih mengarah pada masalah spesifik, tetapi diharapkan dapat membantu permasalahan dalam penyajian informasi prasarana jalan dan jembatan. Penulis merancang sistem informasi dalam pemeliharaan jalan dan jembatankarena dengan sistem informasi ini akan lebih cepat, tepat dan akurat dalam penyajianinformasi kepada pihak-pihak berkepentingan dalam Dinas Pekerjaan Umum (PU) Kabupaten Pasaman Barat
Evolution of bronchial obstruction pattern in children of presсhool age
Authors: Markovskaya A. I. , Potapova N. L. , Gaymolenko I. N. 
Published: July 2021

Introduction. The diagnosis of asthma presents objective difficulties in children aged less than 5 years. Not all children with recurrent virus-induced obstruction can further develop asthma.Aim. To assess the realization of different clinical and pathogenetic variants of bronchoobstructive syndrome in the child population.Materials and methods. Risk factors of 75 patients with bronchoobstructive syndrome in the first 5 years of life were retrospectively evaluated. 57 patients were surveyed using the “Asthma Prediction Tool” questionnaire. At the end of the follow-up period (one year), cases of bronchial asthma were evaluated.Results. A predictive contribution to the implementation of the recurrent variant of bronchoobstructive syndrome has a burdened hereditary allergic anamnesis (OR=5,4, CI 1,79-16,46, p<0,05) and the presence of atopic dermatitis (OR=7,7, CI 2,73-21,95, p><0,05). Symptoms of allergic rhinitis in combination with hypertrophy of the Palatine tonsils in 6,06 and 3,45 times, respectively, increase the risk of bronchial asthma (p><0.05). Conclusion. As a result of research, there are significant factors in the implementation of bronchial asthma such as concomitant allergic diseases in combination with a hereditary background and hypertrophy of the palatine tonsils. The>˂ 0,05) and the presence of atopic dermatitis (OR=7,7, CI 2,73-21,95, p˂ 0,05). Symptoms of allergic rhinitis in combination with hypertrophy of the Palatine tonsils in 6,06 and 3,45 times, respectively, increase the risk of bronchial asthma (p˂ 0.05).Conclusion. As a result of research, there are significant factors in the implementation of bronchial asthma such as concomitant allergic diseases in combination with a hereditary background and hypertrophy of the palatine tonsils. The “Asthma Prediction Tool” questionnaire allows you to predict the development of bronchial asthma in patients with episodic and recurrent bronchial obstruction. The article will be useful for both pediatricians and primary care professionals, as it allows to rationally influence the risks of bronchial asthma formation.
Assessment of indicators of pulmonary volemia and systemic inflammatory response in patients with comorbidity of chronic obstructive pulmonary disease and ischemic heart disease after coronary artery bypass grafting
Authors: Sergeev E. A. , Geltser B. I. , Said Shokh S. M.Kh. , Kotelnikov V. N. , Markelova E. V. 
Published: July 2021

Inroduction. Systemic inflammatory response (SIR) is an obligatory manifestation of operational stress affecting the functional status of patients, which is important to consider in persons with comorbid pathology.Aim. Evaluation of the relationship between pulmonary volemia and SIR indicators in patients with comorbidity of chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) after coronary artery bypass grafting (CABG).Materials and methods. The study included 76 IHD patients aged 53 to 77 years who underwent CABG. Among the surveyed, 2 groups were identified: 39 patients with IHD and 37 – with a combination of IHD and COPD. The following indices were measured by transpulmonary thermodilution: pulmonary blood volume (PBV), extravascular lung water index (EVLWI), pulmonary vascular permeability index (PVPI), pulmonary shunt fraction (Qs/Qt). Determined the concentration in the blood of interleukin 6 and 10 (IL-6, IL-10), tumor necrosis factor-alpha (TNF-α); transforming growth factor-beta1 (TGFβ1), NLR - the ratio of neutrophils to lymphocytes; PLR – the ratio of platelets to lymphocytes.Results. The most pronounced disturbances in the water balance of the lungs, manifested by an increase in EVLWI, PVPI and Qs/Qt were recorded in patients with comorbidity of COPD and IHD immediately after withdrawal from cardiopulmonary bypass. The PBV level at all measurement points in patients with COPD was lower, which indicated the prevalence of right ventricular failure. SIR on operational stress in this category of patients was manifested by the discoordination of the cytokine profile: a sharp increase in the concentration of IL-6 and IL-10 against the background of a relatively stable level of TNFα and TGF-β1, as well as an increase in NLR and PLR.Conclusion. The unidirectional response of pulmonary volemia and SIR indicators to operational stress indicates the pathophysiological relationship of the studied phenomena.
Efficacy of Chemotherapy for Locally Advanced and Metastatic Pancreatic Cancer: A real life experience and outcome from a tertiary referral centre.
Authors: Yasmeen Samia , Shaukat Sabah , Arshad Farah , Badar Farhana , Saeed Kazmi Syed Ather , Ahmad Usman 
Published: July 2021

Introduction: To report response rate, progression-free survival and overall survival in patients with advanced pancreatic cancer treated with different available chemotherapeutic regimens over ten years. Materials and Methods: This is a retrospective observational study. All patients with locally advanced and metastatic pancreatic cancer at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, from January 2008 to December 2017 were studied. Data were collected from the hospital information system. The characteristics and outcomes of all the patients were analyzed. Progression-free survival and overall survival were also estimated. Kaplan Meier curves and Log-rank test were applied, and SPSS version 20 was used for data analysis. Results: Eighty-seven (87) subjects with a median age of 56 years (range 21-76) were included. Sixty-two (71%) subjects were male. The most common tumor location was the head of the pancreas in 46(53%) of all the subjects. Sixty-three (72%) subjects had elevated CA-19.9 values. About 47(54%) subjects had locally advanced pancreatic cancer (LAPC), and 40(46%) subjects had metastatic pancreatic cancer (MPC). Chemotherapy regimens used were FOLFIRINOX in 23(26%), gemcitabine-based 66(65%) and capecitabine-based in 8 (9%) of the subjects. One (1%) subject had a complete response (CR), 12(14%) had a partial response (PR), 10 (11%) had stable disease, and 59(68%) of the subjects had progressive disease (PD). The objective response rate (ORR) was 15%, and the disease control rate (DCR) was 26%. In MPC, the ORR was 10%, DCR was 18%, and tumor progression was seen in 72% of the patients, while in LAPC, the ORR was 19.1, DCR 34% and tumor progression was documented in 64% of the patients, respectively. The FOLFIRNOX chemotherapy regimen had better ORR, DCR and lesser number of progressions as compared to Gemcitabine and Capecitabine based chemotherapy regimens. The Median PFS of the whole group was 32-weeks, and the median OS was 54-weeks. The PFS was significantly higher for LAPC (39 weeks) as compared to the MPC group (25 weeks) (p=0.028). There was no statistically significant difference between the OS of these 2 groups (p=0.451). In addition, PFS was significantly higher with FOLFIRINOX chemotherapy as compared to the other chemotherapy regimens. Regarding OS, there was no statistically significant difference among all chemotherapy regimen groups (p=0.267). Conclusion: Based on our results, FOLFIRINOX remained the most effective chemotherapy regimen despite the dose modifications and toxicities in all groups, indicating that modified FOLFIRINOX could be considered as a first-line regimen in south East Asian population.
Perancangan Komik Tentang Menjaga Identitas Kebangsaan bagi Komunitas Weeaboo Milenial di Indonesia
Authors: Ardandireza Lukas , Mataram Sayid 
Published: July 2021

<p>Kebudayaan adalah salah satu aspek penting dalam identitas bangsa Indonesia. Namun dewasa ini arus globalisasi yang begitu pesat mengakibatkan begitu mudahnya budaya asing untuk merasuk ke sendi-sendi bangsa. Salah satunya adalah kebudayaan Jepang. Budaya Jepang ini dibawa oleh beberapa produk media budaya populer Jepang yaitu diantaranya <em>anime </em>serta <em>manga</em>. Rasa tertarik terhadap produk asing, khususnya <em>anime</em> dan <em>manga</em>, mempengaruhi rasa memiliki identitas bangsanya. Saat ini di Indonesia telah lahir generasi Phi di era millenial yang merupakan generasi penggerak sekaligus pengubah hingga 50 tahun ke depan. Generasi tersebut sangat mudah terpengaruh oleh perkembangan <em>trend</em> global daripada generasi sebelumnya. Kecenderungan perilaku negatif telah muncul dengan adanya komunitas <em>weeabo</em><em>o</em><em> </em>sebagai bentuk ekstrim dari perilaku penggemar budaya Jepang. Sehingga dibutuhkan upaya mempertahankan dan menjaga identitas bangsa Indonesia dikalangan generasi milenial. Bukan tidak mungkin identitas bangsa Indonesia suatu saat akan tergerus dan luntur. Permasalahan yang diangkat dalam penelitian ini adalah bagaimana menjaga identitas kebangsaan bagi komunitas <em>weeaboo</em> milenial di Indonesia serta menciptakan media yang digunakan untuk menyampaikan pesan-pesan guna menjaga identitas bangsa tersebut. Tujuan penelitian ini adalah untuk menjaga identitas bangsa dari pengaruh ekstrim budaya asing di Indonesia. Penelitian kualitatif deskriptif ini menggunakan pendekatan semiotika visual untuk menciptakan media komik. Media komik merupakan media yang relevan dikonsumsi oleh komunitas <em>weeaboo</em> sehingga media tersebut efektif sebagai media perancangan. Hasil yang diperoleh yaitu meskipun para <em>weeaboo</em> merupakan penggamar ekstrim budaya Jepang yang bahkan menganggap budaya Jepang lebih baik daripada budayanya sendiri, namun tidak menutup kemungkinan hal itu bisa diantisipasi dengan adanya upaya menjaga identitas bangsa mereka.</p><p>Kata Kunci: Komik, Generasi millenial, <em>Weeaboo</em>, Identitas bangsa</p>