bluuebunny/crossref_metadata_2025_split huggingface dataset:
A time resolved study of injection backgrounds during the first commissioning phase of SuperKEKB
Authors: Gabriel Miroslav , Simon Frank , Windel Hendrik , Funakoshi Yoshihiro , Hedges Michael , Iida Naoko , Jaegle Igal , Kiesling Christian , van der Kolk Naomi , Lewis Peter , Nakayama Hiroyuki , Ohnishi Yukiyoshi , de Sangro Riccardo , Suetsugu Yusuke , Szalay Marco , Vahsen Sven 
Published: November 2021

AbstractWe report on measurements of beam backgrounds during the first commissioning phase of the SuperKEKB collider in 2016, performed with the plastic scintillator and silicon photomultiplier-based CLAWS detector system. The sub-nanosecond time resolution and single particle detection capability of the sensors allow bunch-by-bunch measurements, enable CLAWS to perform a novel time resolved analysis of beam backgrounds, and make the system uniquely suited for the study of injection backgrounds. We present measurements of various aspects of regular beam background and injection backgrounds which include time structure and decay behavior of injection backgrounds, hit-energy spectra and overall background rates. These measurements show that the elevated background rates following an injection generally last for several milliseconds, with the majority of the background particles typically observed within the first $${500}~\upmu \hbox {s}$$

500

μ
s

. The injection backgrounds exhibit pronounced patterns in time, connected to betatron and synchrotron oscillations in the accelerator rings. The frequencies of these patterns are determined from detector data.
Geodesic flows and the mother of all continued fractions
Authors: Merriman Claire 
Published: November 2021

We extend the Series [The modular surface and continued fractions, J. London Math. Soc. (2) 31(1) (1985) 69–80] connection between the modular surface [Formula: see text], cutting sequences, and regular continued fractions to the slow converging Lehner and Farey continued fractions with digits [Formula: see text] and [Formula: see text] in the notation used for the Lehner continued fractions. We also introduce an alternative insertion and singularization algorithm for Farey expansions and other non-semiregular continued fractions, and an alternative dual expansion to the Farey expansions so that [Formula: see text] is invariant under the natural extension map.
ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation
Authors: Khurshid Shaan , Friedman Samuel , Reeder Christopher , Di Achille Paolo , Diamant Nathaniel , Singh Pulkit , Harrington Lia X. , Wang Xin , Al-Alusi Mostafa A. , Sarma Gopal , Foulkes Andrea S. , Ellinor Patrick T. , Anderson Christopher D. , Ho Jennifer E. , Philippakis Anthony A. , Batra Puneet , Lubitz Steven A. 
Published: November 2021

Background:
Artificial intelligence (AI)–enabled analysis of 12-lead ECGs may facilitate efficient estimation of incident atrial fibrillation (AF) risk. However, it remains unclear whether AI provides meaningful and generalizable improvement in predictive accuracy beyond clinical risk factors for AF.

Methods:
We trained a convolutional neural network (ECG-AI) to infer 5-year incident AF risk using 12-lead ECGs in patients receiving longitudinal primary care at Massachusetts General Hospital (MGH). We then fit 3 Cox proportional hazards models, composed of ECG-AI 5-year AF probability, CHARGE-AF clinical risk score (Cohorts for Heart and Aging in Genomic Epidemiology–Atrial Fibrillation), and terms for both ECG-AI and CHARGE-AF (CH-AI), respectively. We assessed model performance by calculating discrimination (area under the receiver operating characteristic curve) and calibration in an internal test set and 2 external test sets (Brigham and Women’s Hospital [BWH] and UK Biobank). Models were recalibrated to estimate 2-year AF risk in the UK Biobank given limited available follow-up. We used saliency mapping to identify ECG features most influential on ECG-AI risk predictions and assessed correlation between ECG-AI and CHARGE-AF linear predictors.

Results:

The training set comprised 45 770 individuals (age 55±17 years, 53% women, 2171 AF events) and the test sets comprised 83 162 individuals (age 59±13 years, 56% women, 2424 AF events). Area under the receiver operating characteristic curve was comparable using CHARGE-AF (MGH, 0.802 [95% CI, 0.767–0.836]; BWH, 0.752 [95% CI, 0.741–0.763]; UK Biobank, 0.732 [95% CI, 0.704–0.759]) and ECG-AI (MGH, 0.823 [95% CI, 0.790–0.856]; BWH, 0.747 [95% CI, 0.736–0.759]; UK Biobank, 0.705 [95% CI, 0.673–0.737]). Area under the receiver operating characteristic curve was highest using CH-AI (MGH, 0.838 [95% CI, 0.807 to 0.869]; BWH, 0.777 [95% CI, 0.766 to 0.788]; UK Biobank, 0.746 [95% CI, 0.716 to 0.776]). Calibration error was low using ECG-AI (MGH, 0.0212; BWH, 0.0129; UK Biobank, 0.0035) and CH-AI (MGH, 0.012; BWH, 0.0108; UK Biobank, 0.0001). In saliency analyses, the ECG P-wave had the greatest influence on AI model predictions. ECG-AI and CHARGE-AF linear predictors were correlated (Pearson
r
: MGH, 0.61; BWH, 0.66; UK Biobank, 0.41).

Conclusions:
AI-based analysis of 12-lead ECGs has similar predictive usefulness to a clinical risk factor model for incident AF and the approaches are complementary. ECG-AI may enable efficient quantification of future AF risk.
Nonadherence in Hypertension: How to Develop and Implement Chemical Adherence Testing
Authors: Lane Dan , Lawson Alexander , Burns Angela , Azizi Michel , Burnier Michel , Jones Donald J.L. , Kably Benjamin , Khunti Kamlesh , Kreutz Reinhold , Patel Prashanth , Persu Alexandre , Spiering Wilko , Toennes Stefan W. , Tomaszewski Maciej , Williams Bryan , Gupta Pankaj , Dasgupta Indranil ,   Endorsed by the European Society of Hypertension (ESH) Working Group on Cardiovascular Pharmacotherapy and Adherence
Published: November 2021

Nonadherence to antihypertensive medication is common, especially in those with apparent treatment-resistant hypertension (true treatment-resistant hypertension requires exclusion of nonadherence), and its routine detection is supported by clinical guidelines. Chemical adherence testing is a reliable and valid method to detect adherence, yet methods are unstandardized and are not ubiquitous. This article describes the principles of chemical adherence testing for hypertensive patients and provides a set of recommendations for centers wishing to develop the test.
We recommend testing should be done in either of two instances: (1) in those who have resistant hypertension or (2) in those on 2 antihypertensives who have a less than 10 mm Hg drop in systolic blood pressure on addition of the second antihypertensive medication. Furthermore, we recommend that verbal consent is secured before undertaking the test, and the results should be discussed with the patient.
Based on medications prescribed in United Kingdom, European Union, and United States, we list top 20 to 24 drugs that cover >95% of hypertension prescriptions which may be included in the testing panel. Information required to identify these medications on mass spectrometry platforms is likewise provided. We discuss issues related to ethics, sample collection, transport, stability, urine versus blood samples, qualitative versus quantitative testing, pharmacokinetics, instrumentation, validation, quality assurance, and gaps in knowledge. We consider how to best present, interpret, and discuss chemical adherence test results with the patient.
In summary, this guidance should help clinicians and their laboratories in the development of chemical adherence testing of prescribed antihypertensive drugs.
ParsiNLU: A Suite of Language Understanding Challenges for Persian
Authors: Khashabi Daniel , Cohan Arman , Shakeri Siamak , Hosseini Pedram , Pezeshkpour Pouya , Alikhani Malihe , Aminnaseri Moin , Bitaab Marzieh , Brahman Faeze , Ghazarian Sarik , Gheini Mozhdeh , Kabiri Arman , Mahabagdi Rabeeh Karimi , Memarrast Omid , Mosallanezhad Ahmadreza , Noury Erfan , Raji Shahab , Rasooli Mohammad Sadegh , Sadeghi Sepideh , Azer Erfan Sadeqi , Samghabadi Niloofar Safi , Shafaei Mahsa , Sheybani Saber , Tazarv Ali , Yaghoobzadeh Yadollah 
Published: November 2021

Abstract
Despite the progress made in recent years in addressing natural language understanding (NLU) challenges, the majority of this progress remains to be concentrated on resource-rich languages like English. This work focuses on Persian language, one of the widely spoken languages in the world, and yet there are few NLU datasets available for this language. The availability of high-quality evaluation datasets is a necessity for reliable assessment of the progress on different NLU tasks and domains. We introduce ParsiNLU, the first benchmark in Persian language that includes a range of language understanding tasks—reading comprehension, textual entailment, and so on. These datasets are collected in a multitude of ways, often involving manual annotations by native speakers. This results in over 14.5k new instances across 6 distinct NLU tasks. Additionally, we present the first results on state-of-the-art monolingual and multilingual pre-trained language models on this benchmark and compare them with human performance, which provides valuable insights into our ability to tackle natural language understanding challenges in Persian. We hope ParsiNLU fosters further research and advances in Persian language understanding.1
Processable poly(ether ether ketone imide)s
Authors: Tamboli Aslam B , Ghodke Shivaji D , Diwate Arati V , Joshi Makrand D , Ubale Vijay P , Maldar Noormahmad N 
Published: November 2021

New aromatic poly(ether ether ketone imide)s, [PEEKimide]s, were synthesized successfully from 1,3-bis-4′-(4″-aminophenoxy benzoyl) benzene and various commercially available aromatic dianhydrides, such as pyromellitic dianhydride (PMDA), 3,3′,4,4′-benzophenone tetracarboxylic dianhydride (BTDA), 3,3′,4,4′-biphenyl tetracarboxylic dianhydride (BPDA), 4,4′-oxydiphthalic anhydride (OPDA) and 4,4′-(hexafluro isoproylidene) diphthalic anhydride (HFDA), by two step polycondensation method. These PEEKimides were characterized by FT-IR, solubility in organic solvents, inherent viscosity, DSC, TGA and WXRD. Inherent viscosities of the precursor poly(ether ether ketone amic acid)s were in the range of 0.23–0.40 dl/g in DMF, indicating formation of moderate to high molecular weights. These poly(ether ether ketone imide)s showed good solubility in polar aprotic solvents such as N,N-dimethylacetamide (DMAc), N-methyl 2-pyrrolidone (NMP), N,N-dimethylformamide (DMF) and dimethyl sulphoxide (DMSO) and had glass transition temperatures in the range 245–279°C. Poly(ether ether ketone imide)s showed no weight loss below 280°C; temperatures for 10% weight loss (T10) were in the range of 406–483°C and char yields at 800°C were 17–34%, indicating their good thermal stability. All these poly(ether ether ketone imide)s were amorphous in nature, as per patterns of WXRD which exhibited diffuse broad halos at (2θ = 10–30°) and amorphous nature was reflected in polymer’s good solubility in common organic solvents.
Effect of Low-Dose Gamma Radiation and Lipoic Acid on High- Radiation-Dose Induced Rat Brain Injuries
Authors: Abdel-Aziz Nahed , Elkady Ahmed A , Elgazzar Eman M 
Published: November 2021

Aim This work aims to investigate the possible radio-adaptive mechanisms induced by low-dose (LD) whole-body γ-irradiation alone or combined with alpha-lipoic acid (ALA) administration in modulating high-dose (HD) head irradiation–induced brain injury in rats. Materials and Methods Rats were irradiated with LD (.25 Gy) 24 hours prior HD (20 Gy), and subjected to ALA (100 mg/kg/day) 5 minutes after HD and continued for 10 days. At the end of the experiment, animals were sacrificed and brain samples were dissected for biochemical and histopathological examinations. Results HD irradiation-induced brain injury as manifested by elevation of oxidative stress, DNA damage, apoptotic, and inflammatory markers in brain tissue. Histological examination of brain sections showed marked alterations. However, LD alone or combined with ALA ameliorated the changes induced by HD. Conclusion Under the present experimental conditions, LD whole-body irradiation exhibited neuroprotective activity against detrimental effects of a subsequent HD head irradiation. This effect might be due to the adaptive response induced by LD that activated the anti-oxidative, anti-apoptotic, and anti-inflammatory mechanisms in the affected animals making them able to cope with the subsequent high-dose exposure. However, the combined LD exposure and ALA supplementation produced a further modulating effect in the HD-irradiated rats.
Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
Authors: Zhang Yuzhuo , Zhao Ying , Wei Chenglu , Li Yongrong , Aslam Hira , Feng Qingmin , Huang Qing , Zheng Yu , Lv Feifen , Hao Wei , Li Jike 
Published: November 2021

Abstract
Background
Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension.

Methods
From January 2018 to December 2019, we assessed UACR in a total of 599 hypertensive Chinese Hainan patients. We defined ERD as a UACR between 30 mg/g and 300 mg/g. We analysed differences between qualitative variables using the chi-squared (χ2) test. We calculated correlations between UACR and age, hypertension duration (HD), systolic blood pressure (SBP), and diastolic blood pressure (DBP) using the Spearman’s rho test. To determine the odds ratio (OR), we evaluated binary logistic regression models.

Results
Among the 599 patients, 281 (46.9%) were found to have ERD. ERD and factors related to sex, body mass index (BMI), and SBP did not differ significantly (all, p>0.05). Our main findings showed that age, HD, and DBP were associated with ERD (p<0.01, respectively). Furthermore, age ≥ 65 years, HD ≥10 years, DBP ≥ 90 mmHg, SBP ≥ 160 mmHg, and diabetes differed significantly according to ERD status (p < 0.05, respectively). In multivariate analysis using stepwise regression, age (OR = 1.468), DBP (OR = 1.853), and diabetes (OR = 2.031) were significant independent predictors of ERD. The area under the receiver operating characteristic (ROC) curve was 0.677, and the sensitivity and specificity of the optimal cut-off value were 44.5 and 81.1%, respectively.

Conclusions
Common medical comorbidities are associated with ERD; age, DBP, and diabetes are independent risk factors for ERD in patients with essential hypertension who live in the Chinese tropics. Early monitoring of the UACR, as well as control of blood glucose and DBP, can effectively delay ERD.
Social support and subjective assessment of psychophysical condition, health, and satisfaction with quality of life among women after pregnancy loss
Authors: Iwanowicz-Palus Grażyna , Mróz Mariola , Bień Agnieszka , Jurek Krzysztof 
Published: November 2021

Abstract
Background
The task of modern medicine is not just to heal, but also to improve the patient’s well-being and achieve non-medical goals in the therapy process that enable effective physical, mental and social functioning of the patient. Social support in difficult situations mobilizes an individual’s strength and resources to cope with problems. Research on social support and women’s condition after pregnancy loss reflects a holistic approach to the patient and is important from the perspective of increasing the level of hospital care.

Objective
The aim of our study was to assess the impact of social support on the psychophysical condition, health, and satisfaction with quality of life among women after miscarriage and ectopic pregnancy.

Methods
The cross-sectional study was carried out in a group of 500 patients after miscarriage and 110 with ectopic pregnancy, hospitalized in hospitals in Lublin (Poland). The study was conducted with the use of a diagnostic survey, comprising the Berlin Social Support Scales (BSSS) and an original survey questionnaire (psychophysical condition, satisfaction with health and quality of life on a scale of 1–4, sources of support on a scale of 1–10, with 1 being the poorest rating).

Results
Respondents after miscarriage and those after ectopic pregnancy assigned the highest scores to the degree of perceived available instrumental support (respectively, miscarriage: M = 3.79, EP: M = 3.77). Women after pregnancy loss assigned the highest score to the support obtained from their partner (respectively, miscarriage: M = 9.26, EP: M = 9.23). Social support was significantly correlated with the condition of patients hospitalized as a result of pregnancy loss (p < 0.05). The assessment of psychophysical condition, health, and QoL of the respondents is determined by their education, financial standing, and obstetric history (p < 0.05).

Conclusions
Women hospitalized due to miscarriage and ectopic pregnancy assigned high scores to the level of perceived available instrumental, emotional, and actually received social support. There is a positive relationship between social support and subjective opinion about psychophysical condition, health and satisfaction with quality of life among women after pregnancy loss. The assessment is determined by sociodemographic factors and the respondents’ obstetric history.
Trends of maternal health service coverage in the Democratic Republic of the Congo: a pooled cross-sectional study of MICS 2010 to 2018
Authors: Guo Fuyu , Qi Xinran , Xiong Huayi , He Qiwei , Zhang Tingkai , Zou Siyu , Wang Hanyu , Takesue Rie , Tang Kun 
Published: November 2021

Abstract
Background
Maternal health services are essential for reducing maternal and newborn mortality. However, maternal health service status in the Democratic Republic of the Congo (DRC) remains poorly understood. This study aims to explore the trends of antenatal care (ANC) and skilled birth attendance coverage in the past decade in the DRC.

Methods
The 13,361 participants were from two rounds of Multiple Indicators Cluster Survey (MICS) conducted by the National Institute of Statistics of the Ministry of Planning of the DRC, in collaboration with the United Nations Children’s Fund (UNICEF), in 2010 and 2017-2018. A regression-based method was adopted to calculate adjusted coverage of ANC and skilled birth attendance. Subgroup analysis based on different socioeconomic status (SES) was conducted to explore the impact of domestic conflicts.

Results
From 2010 to 2018, the overall weighted ANC coverage in the DRC declined from 87.3 % (95 % CI 86.1–88.0 %) to 82.4 % (95 % CI 81.1–84.0 %), while the overall weighted skilled birth attendance coverage increased from 74.2 % (95 % CI 72.5–76.0 %) to 85.2 % (95 % CI 84.1–86.0 %). Adjusted ANC coverage and adjusted skilled birth attendant coverage both declined in Kasai Oriental, but increased in Nord Kivu and Sud Kivu. In Kasai Occidental, ANC coverage declined, but skilled birth coverage increased. In the Kasai region, the largest decline in adjusted coverage of ANC was found among the poorest women. However, in the Kivu region, both the adjusted coverage of ANC and skilled birth attendance increased among the poorest women.

Conclusions
Due to ongoing conflicts, there has been a systemic deterioration of maternal healthcare coverage in some regions of the DRC, particularly among people with low SES. However, in other regions, maternal healthcare services were not severely disrupted possibly due to substantial international health assistance.
Topical NSAIDs, intravitreal dexamethasone and peribulbar triamcinolone for pseudophakic macular edema
Authors: Obis Javier , Arias Luis , Lorenzo Daniel , Padron-Perez Noel , Garcia-Bru Pere , Cobos Estefania , Morwani Rahul , Caminal Jose 
Published: November 2021

Abstract
Background
The purpose of this study is to assess the effectiveness of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids (intravitreal dexamethasone and peribulbar triamcinolone) in treating pseudophakic macular edema (PME).

Methods
Retrospective study of 33 eyes. Variables included best corrected visual acuity (BCVA; logMAR scale) and central retinal thickness (CRT) and central choroidal thickness (CCT) assessed with swept-source OCT. All patients were initially prescribed topical NSAIDs and reevaluated after 2 months. If improvement in BCVA or CRT was noted, topical NSAIDs were continued until resolution. If no improvement was observed at 2 months or subsequent visits, intravitreal dexamethasone implant was performed. Patients who refused intravitreal treatment were offered peribulbar triamcinolone.

Results
After treatment with topical NSAIDs for a median of 2 months, BCVA increased significantly from 0.5 to 0.3 while CRT decreased significantly from 435 to 316 μm. PME resolved in 19 of the 33 eyes (57.6%). Of the 14 recalcitrant cases, 13 were treated with corticosteroids. Of these 13 cases, 9 (69.2%) resolved. BCVA increased non-significantly from 0.7 to 0.4. CRT and CCT decreased significantly from 492 to 317 μm and from 204 to 182 μm respectively.

Conclusions
The overall success rate of the treatment algorithm was greater than 80%, a remarkable finding considering that no randomized study has yet been conducted to determine the optimal therapeutic protocol for PME. This is the first study to evaluate choroidal thickness in PME using SS-OCT, which could play a key role in its pathophysiology and provide useful information to improve the management of PME.
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice
Authors: Liu Huan , Chu Shujuan , Wu Zhilin 
Published: November 2021

Abstract
Background
Toll-like receptor 4 (TLR4) is a pattern recognition receptor of the innate immune system. TLR4 contributes to many aging-related chronic diseases. However, whether TLR4 is involved in cardiovascular injury during the aging process has not been investigated.

Methods
The effects of TLR4 on the cardiovascular system of aged mice were investigated in TLR4−/− mice. An intraperitoneal glucose tolerance test (IPGTT) and insulin sensitivity test (IST) were conducted to evaluate global insulin sensitivity. Echocardiography was used to measure cardiac structure and performance. An isolated artery ring assay was used to measure the vasodilator function of the thoracic aorta. The inflammatory response was reflected by the serum concentration of cytokines.

Results
TLR4 expression increased in the hearts and aortas of mice in an age-dependent manner. Loss of TLR4 increased insulin sensitivity in aged mice. Moreover, loss of TLR4 improved cardiac performance and endothelium-dependent vascular relaxation in aged mice. Importantly, the increases in serum inflammatory cytokines and oxidative stress in the heart and aorta were also inhibited by TLR4 deficiency.

Conclusion
In summary, loss of TLR4 improved cardiac performance and endothelium-dependent vascular relaxation in aged mice. The reduced inflammatory responses and oxidative stress may be the reason for the protective effects of TLR4 deficiency during aging. Our study indicates that targeting TLR4 is a potential therapeutic strategy for preventing aging-related cardiovascular disease.