bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cash Management in Russian Metallurgical and Oil and Gas Companies
Authors: Olga  , Panasenko Kristina 
Published: November 2021

The problem of money management has remained relevant over the past years. The aim of the study is to assess the impact of debt and cash flow on the amount of cash on companies with and without financial constraints. The main hypothesis of the study is that the impact of debt and cash flow on the level of cash depends on financial constraints which were taken as two proxy variables – dividend payment and bond rating. To substantiate the hypothesis put forward, a regression model of the influence of debt and cash flow on the level of cash is built in the work.
For the analysis, large Russian companies in the metallurgical and oil and gas industries were sorted in accordance with financial constraints. Based on the results of the constructed regression model, the following conclusions can be drawn. Borrowed funds of companies negatively affect the amount of cash on the balance sheet, regardless of the presence andtype of financial constraints. Cash flow is not statistically significant for companies without financial constraints.
This study has some limitations. The research results can be useful for corporate CFOs in order to optimize cash balances.
Danoval and omnadren effect on the patients with dysfunctional uterine bleedings during the premenopause
Authors: Gumenyuk E. G. , Samorodinova L. A. 
Published: November 2021

Initial level of gonadothropic, steroid hormones in the blood, receptors of estradiol and progesteron of the endometrium in the patients with dysfunctional uterine bleedings during the premenopause, and their dunamics during and after hormone therapy were studied.
Danoval and oxy prog esterone-capronat in combination with omnadren had different effect on the parameters of the hormonal homeostasis and receptor apparatus of the endometrium. Antigonadоthropic effect of danoval results in FSG level reduction, estradiol and progesterone decrease in the blood and that of steroid receptors in the endometrium, that did not take place with other therapies. The effectiveness of the treatment with danoval was 88,24%, and it was 62,50% when oxy prog esterone-capronat with omnadren therapy was used.
It is concluded that danoval prescription to the patients with dysfunctional uterine bleedings during the menopause is more expedient for the wide spectrum of antigonadothropic effect.
A Perfectly Matched Layer Technique Applied to Lattice Spring Model in Seismic Wavefield Forward Modeling for Poisson’s Solids
Authors: Tang Jinxuan , Zhou Hui , Jiang Chuntao , Xia Muming , Chen Hanming , Zheng Jinxin 
Published: November 2021

ABSTRACTAs a complementary way to traditional wave-equation-based forward modeling methods, lattice spring model (LSM) is introduced into seismology for wavefield modeling owing to its remarkable stability, high-calculation accuracy, and flexibility in choosing simulation meshes, and so forth. The LSM simulates seismic-wave propagation from a micromechanics perspective, thus enjoying comprehensive characterization of elastic dynamics in complex media. Incorporating an absorbing boundary condition (ABC) is necessary for wavefield modeling to avoid the artificial reflections caused by truncated boundaries. To the best of our knowledge, the perfectly matched layer (PML) method has been a routine ABC in the wave-equation-based numerical modeling of wave physics. However, it has not been used in the nonwave-equation-based LSM simulations. In this work, we want to apply PML to LSM to attenuate the boundary reflections. We divide the whole simulation region into PML region and inner region, PML region surrounds the inner region. To incorporate PML to LSM, we establish elastic-wave equations corresponding to LSM. The simulation in the PML region is conducted using the established wave equations and the simulation in the inner region is conducted using LSM. Three simulation examples show that the PML scheme is effective and outperforms Gaussian ABC.
Fast and Robust Earthquake Source Spectra and Moment Magnitudes from Envelope Inversion
Authors: Eulenfeld Tom , Dahm Torsten , Heimann Sebastian , Wegler Ulrich 
Published: November 2021

ABSTRACTWith the present study, we introduce a fast and robust method to calculate the source displacement spectra of small earthquakes on a local to regional scale. The work is based on the publicly available Qopen method of full envelope inversion, which is further tuned for the given purpose. Important source parameters—seismic moment, moment magnitude, corner frequency, and high-frequency fall off—are determined from the source spectra by fitting a simple earthquake source model. The method is demonstrated by means of a data set comprising the 2018 West Bohemia earthquake swarm. We report moment magnitudes, corner frequencies, and centroid moment tensors inverted from short-period body waves with the Grond package for all earthquakes with a local magnitude larger than 1.8. Moment magnitudes calculated by envelope inversion show a very good agreement to moment magnitudes resulting from the probabilisitc moment tensor inversion. Furthermore, source displacement spectra from envelope inversion show a good agreement with spectra obtained by multiple taper analysis of the direct onsets of body waves but are not affected by the large scatter of the second. The seismic moments obtained with the envelope inversion scale with corner frequencies according to M0∝fc−4.7. Earthquakes of the present data set result in a smaller stress drop for smaller magnitudes. Self-similarity of earthquake rupture is not observed. In addition, we report frequency-dependent site amplification at the used stations.
Correlation of ER PR receptors with other prognostic parameters of breast carcinoma
Authors: Pawar Vishrabdha Rahul , Anand Nekta , Zaidi Shahnaz 
Published: November 2021

To study the MRM specimens for size, grade of the tumor, LVI and LN metastases and the ER/PR receptors of the tumor. To study the association of ER/PR status with the above mentioned prognostic parameters. This three-year study includes 72 histopathologically confirmed cases of carcinoma breast. The tumor type, grade, LNM, LVE were reported on H & E. The ER-PR study was done of all 72 cases. The tumor size, grade, LNM, LVE were correlated with receptor status. Out of 72 cases majority (53%) of cases were in 41-50 years of age group, and tumor size was between 2-4 cm in (54.16%) cases; majority were of grade II carcinoma (60%) of which 59% were ER-PR positive. Out of 46 cases with negative LNM and LVE, 30 cases (65%) were ER-PR positive. In our observation there is no association between higher histological grade and ER-PR status. No obvious correlation with tumor size was noted. But increase in tumor size could also be a poor predictor of ER-PR status. LNM, LVE is poor predictor of ER-PR status.
D Dimer – Prognostic indicator for disease severity in patients hospitalised with COVID 19
Authors: Banga Vineet , Jain Stuti 
Published: November 2021

Patients of Covid 19 infections present with different severity. Levels of D Dimer in these patients can be correlated with disease severity for management and prognosis.To evaluate the usefulness of D-Dimer levels in blood to correlate with disease severity in COVID 19 patients.Retrospective study was done in Department of Pathology of Secondary Care hospital that became designated covid hospital from May 2021 to June 2021 on 60 COVID 19 positive admitted patients. D dimer levels were analysed and correlated with clinical severity of disease.Out of total 60 patients, 33 were in mild, 23 in moderate and 4 were in severe category. In mild cases D Dimer varies from 43 ng/ml to 183 ng/ml. In moderate cases D Dimer varies from 270 ng/ml to 991 ng/ml. In severe cases D Dimer varies from 1043 ng/ml to 2463 ng/ml. The study suggests cut off levels for D Dimer as up to 200 ng/ml for mild, 200-1000 ng/ml for moderate and more than 1000 ng/ml for severe category in COVID 19 patients.D dimer helps in identifying severe disease and can be used as an essential biomarker in developing the management protocol for COVID 19 patients.
Apport de la protéomique à la découverte de biomarqueurs pour l’étude de la couleur de la viande bovine
Authors: GAGAOUA Mohammed , TERLOUW Claudia , PICARD2 Brigitte 
Published: November 2021

Cette synthèse s’intéresse à l’apport de l’analyse protéomique et à la découverte de biomarqueurs pour mieux comprendre les mécanismes sous-jacents à la variabilité et la stabilité de la couleur de la viande bovine. L’analyse intégrative des données protéomiques de la littérature révèle les principales signatures moléculaires et les mécanismes biologiques à l’origine de la couleur de la viande bovine. Une fouille de données des études protéomiques récentes sur la couleur de la viande a permis d’agréger 79 protéines biomarqueurs potentiels issues de 13 études. Les protéines sont associées à 6 processus biologiques interconnectés : métabolisme énergétique, réponses au stress cellulaire et oxydant, structure, voies de signalisation, protéolyse et apoptose. Avec un seuil d’identification dans au moins 3 études, 27 protéines ont été présélectionnées parmi lesquelles la β-énolase, la peroxiredoxine 6, la protéine de stress HSP27, la phosphoglucomutase 1, la superoxyde dismutase 1 et la μ-calpaïne ont été identifiées par au moins 5 études comme jouant un rôle significatif dans les variations de la couleur de la viande bovine.
Abnormalities of EEG Microstates In Drug-Naïve, First-Episode Schizophrenia
Authors: Sun Qiaoling , Zhao Linlin , Tan Liwen 
Published: November 2021

Abstract
Objective: Microstate analysis is a powerful tool to probe the brain functions, and changes in microstates under electroencephalography (EEG) have been repeatedly reported in patients with schizophrenia. This study aimed to investigate the dynamics of EEG microstates in drug-naïve, first-episode schizophrenia (FE-SCH) and to test the relationship between EEG microstates and clinical symptoms.Methods: Resting-state EEG were recorded for 23 patients with FE-SCH and 23 healthy controls using a 64-channel cap. Three parameters, i.e., contribution, duration, and occurrence, of the four microstate classes were calculated. Group differences in EEG microstates and their clinical symptoms (assessed using the Positive and Negative Syndrome Scale) were analyzed.Results: Compared with healthy controls, patients with FE-SCH showed increased duration, occurrence and contribution of microstate class C and decreased contribution and occurrence of microstate class D. In addition, the score of positive symptoms in PANSS was negatively correlated with the occurrence of microstate D.Conclusions: Our findings showed abnormal patterns of EEG microstates in drug-naïve, first-episode schizophrenia, which might help distinguish individuals with schizophrenia in the early stage and develop early intervention strategies.
Modelling the Spatial Distribution of Habitats of Main Cephalopod Taxa in Inshore Waters of Zhejiang Province at Spring and Autumn
Authors: Chen Feng , Wei Guangen , Li Nan , Fang Zhou , Zhang Hongliang , Zhou Yongdong , Jiang Rijin 
Published: November 2021

Abstract
Due to the declining catch of the ground fish, cephalopod as a short-lived invertebrate with commercially important value has become the main fishery target species of East China Sea (ECS) in recent decades. Therefore, it is necessary to explore its habitat for the sustainable utilization. In this study, with the individual density of cephalopod derived from the fishery survey data in the coast of Zhejiang Province from 2014 to 2019 and remote sensing data, the habitat suitability index (HSI) model of typical cephalopod (Loliginidae, Octopodidae, Sepiidae, and Sepiolidae) in spring and autumn was obtained. The habitat isolines of core zone, common zone and marginal zone were also established and then compared among different typical cephalopod taxa based on arithmetic mean model (AMM). The distribution ranges of SST and chlorophyll-a of cephalopod were respectively 12.95~21.91 ℃ and 0.52~5.57 mg/m3 in spring and 17.02~22.94℃ and 0.26~6.02 mg/m3 in autumn. The prediction results of the HSI model suggested that the cephalopod distribution areas were concentrated in the range of 122°~124°E, 29.5°~31°N, displaying the distribution direction from coastal area to the northeast. The accumulative density of the four cephalopod taxa in the area with HSI>0.6 accounted for 73.9%. The overlap between the prediction results of HSI model and the actual density in 2019 also proved the good predictability of HSI model based on AMM. Four cephalopod taxa showed distribution differences. Sepiolidae had the widest distribution area, whereas Octopodidae had the narrowest distribution area.
Dimethyl itaconate attenuates CFA-induced inflammatory pain via NLRP3/ IL-1β signaling pathway
Authors: Lin Jiaqi , Ren Jinxuan , Zhu Bin , Dai Yi , Gao Dave Schwinn , Xia Suyun , Cheng Zhenzhen , Huang Yangyuxin , Yu Lina 
Published: November 2021

Abstract
Background
Itaconate plays potent anti-inflammatory effects and has gradually been discovered as a promising drug candidate for treating inflammatory diseases. However, its roles and underlying mechanism on pain remain unknown.
Methods
In the current work, we investigated the effects and mechanisms of dimethyl itaconate (DI, a derivative of itaconate) in a mouse model of complete Freund's adjuvant (CFA)-induced inflammatory pain. Male/Female C57 BL/6 mice were randomly divided into five groups: a vehicle group, an CFA group ,an CFA+PBS group and an CFA + DI(10mg /d and 20 mg/d) group.DI was performed for 11 consecutive days after CFA models were established.Paw withdrawal frequencies and paw withdrawal latencies were used to Behavioral Tests. The activation of macrophages and microglia, the level of proinflammatory cytokine production, the number of M1/M2 macrophages were evaluated .The possible involvement of the NLRP3/ IL-1β signaling pathway was also investigated.
Results
DI significantly reduced mechanical allodynia and thermal hyperalgesia, decreased peripheral inflammatory cell infiltration and the expression of pro-inflammatory factors IL-1β and TNF-α, and upregulated anti-inflammatory factor IL-10. Interestingly, DI promoted macrophages at the inflammatory site polarization from M1 into M2 type. Additionally, DI inhibited activation of macrophages in dorsal root ganglion (DRG) and microglia in the spinal cord, exhibiting reduced expressions of pro-inflammatory cytokines. Mechanismly, DI exerts the analgesic action primarily via inhibiting the activation of NLRP3 inflammasome complex and the release of IL-1β in derived and resident macrophages in the hind paw, DRG and spinal cord.
Conclusion
DI could alleviate the pain-like behavior of CFA mice by inhibiting the infiltration of plantar inflammatory cells and macrophages activation in DRG and microglia in the spinal cord. The analgesic behavior of itaconate was related to the inhibition of NLRP3 inflammasome. This study suggested possible evidence for prospective itaconate utilization in the management of inflammatory pain for the first time.
Utilization status of sexual and reproductive health services among high school students in assosa zone; western ethiopia, 2021.
Authors: Hambisa Hunduma Dina , Kassa Simachew , Shiferaw Shumiye 
Published: November 2021

Abstract
Introduction: - Sexual and reproductive health service is critical for youths; because it does not only set the stage for health beyond the reproductive years; it also affects the health of the next generation. Youth is one of life’s most fascinating and complex life stages and accompanied by special sexual and reproductive health needs.Objective: - This study was aimed to determine; utilization status of sexual and reproductive health services and associated factors among high school students in Assosa Zone Western Ethiopia. Methods: - School-based quantitative cross sectional study was carried out among all students from systematically selected in high school of Assosa Zone. Total of 400 samples were proportionally allocated for the stratum and eligible students in were interviewed. Pretested structured questionnaires were employed to obtain quantitative data. The collected data was interred into Epidata version 3.1 and analysed using SPSS version 25 software.Results: - Over all utilization of sexual and reproductive health services by youth students was 32% in the past six months. Counseling services was the major (33.6%) service utilized and Private clinic was the major 73% place of sexual and reproductive health service utilized. Having pocket money [95 %CI (AOR=2.81(2.35, 5.09)], being sexually active [95 %CI (AOR=1.82(1.25, 3.26)], parental discussion [95 %CI (AOR=2.78(1.59, 4.67)], peer education was also significantly associated with utilization of sexual and reproductive health services. Conclusions: - Over all utilization of sexual and reproductive health service among youth students in the past six months was 32%. To improve youth’s sexual and reproductive health service utilization; increasing accessibility, awareness creation at all levels as well as making the service confidential should be interventional areas.
Optical Coherence Tomography Angiography in Patients with Amblyopia
Authors: Rajavi Zhale , Sabbaghi Hamideh , Hassanpour Kiana , Ahmadieh Hamid , Kheiri Bahareh , Rajabpour Mojtaba , Nourinia Ramin 
Published: November 2021

Abstract
Purpose: To determine the OCTA parameters including foveal avascular zone (FAZ) and vessel density (VD) in the amblyopic eyes compared with the fellow sound eyes and the eyes of the non- amblyopic subjects. Methods: In this case- control study, a total of 62 eyes from unilateral amblyopic children (n= 23) and the age- and sex- matched healthy children (n= 8) were included. The sound eye of the amblyopic children was considered as the internal control (n= 23) and the both eyes of the non- amblyopic children (n= 16) were considered as the external control. All participants underwent image recording with the optical coherence tomography angiography (OCTA) Results: The average age of 23 cases and 8 controls were 9.86±3.12 and 8.5±2.35 years, respectively. Twelve patients (52.2 %) in the case group and 8 subjects (50%) in the control group were female. Macular VD in different regions of superficial and deep capillary plexuses (SCP, DCP) were comparable amongst the case group and both the internal and the external control groups. The average FAZ area was 0.26±0.06 µm2 in amblyopic eyes that was significantly larger than in the fellow eyes (0.21±0.06 µm2; P=0.007) and was comparable to the healthy controls. Conclusion: Lack of significant difference of the macular vessel density between the amblyopic and non- amblyopic eyes of the both internal and external controls may be attributed to this fact that the changes of the retinal vascular density cannot be considered as the pathogenesis of amblyopia.
Spatial Occurrence and Sources of Polycyclic Aromatic Hydrocarbons in Sediments Drive the Ecological Risk of Taihu Lake, China
Authors: Lang Xiulu , He Xinghua , Wang Yanhua , Chen Xi , Zhang Mingli , Zhao Zihan , Sun Tian 
Published: November 2021

Abstract
To study the spatial occurrence, sources, and ecological risks of 16 PAHs, surface sediments had been collected from seven major areas of Taihu Lake, China in April 2021. Results showed that the concentrations of ∑16PAHs varied between 1381.48~4682.16 ng g-1, and the contents of BghiP in each sample were the highest. The PAHs concentrations in the sediments near the lakeshore were much higher than those in the central area of the lake. The sedimentary ∑16PAHs were mainly composed of molecular-weight monomers and 4-ring PAHs showed superiority (35.69%~45.02%). According to the ratio of PAH monomer, the sedimentary PAHs in Taihu Lake were dominantly derived from the combustion. Through the biological toxicity assessment and the BaP equivalent (BaPE), great biological risks of PAHs monomers i.e. DahA and IcdP were found. Both concentrations of ∑16PAHs and dominant 4~6-ring monomers accompanied by carcinogenic risks in many areas of Taihu Lake increased. It is necessary to strengthen monitoring and take measures to control the input of organic pollutants.
Growth Hormone Secretagogue Peptide A233 Up-Regulates Mx Expression in Teleost Fish In Vitro and In Vivo
Authors: Rodriguez Rebeca Martinez , Fernandez-Trujillo Maria Alejandra , Hernandez Liz , Page Adrián , Béjar Julia , Estrada Mario Pablo 
Published: November 2021

Abstract
Aquaculture constitutes an alternative source for food production and contributes to the reduction of indiscriminate catch of aquatic organisms from their natural environment (Diaz & Neira, 2005; Beveridge et al., 2013). However, high mortality during larval state remains a challenge in this sector, mainly because of factors like diets and diseases induced by pathogens (Helvik et al., 2009; Stentiford et al., 2017). Therefore, growth and health management is a key strategy for sustainable aquaculture (Martinez et al., 2016a).
CARM1 Promotes Gastric Cancer Progression by Regulating TFE3 Mediated Autophagy Enhancement via Cytoplasmic AMPK-mTOR and Nuclear CARM1-TFE3 Signaling Pathways
Authors: Yang Suzhen , Zhang Jing , Chen Di , Cao Jiayi , Zheng Ying , Han Yuying , Jin Yirong , Wang Shuhui , Wang Ting , Ma Lin , Luo Tingting , Wang Yan , Qin Wen , Dong Lei 
Published: November 2021

Abstract
Background: The role of CARM1 in tumors is contradictory. It acts as an oncogene in most kinds of cancers while inhibits the progression of liver and pancreatic cancers. CARM1 has recently been reported to regulate autophagy, which is also context-dependent. However, the effect of CARM1 on gastric cancer has not been studied. We aimed to explore whether CARM1 was involved in the progression of gastric cancer by regulating autophagy.Methods: The clinical values of CARM1 and autophagy in gastric cancer were determined by immunohistochemistry and qRT-PCR. Transmission electron microscopy, immunofluorescence and western blotting were applied to recognize autophagy. The role of CARM1 in gastric cancer was investigated by CCK8, colony formation and flow cytometry assays in vitro and xenograft model in vivo. Immunoprecipitation assay was performed to illustrate the interaction of CARM1 and TFE3.Results: CARM1 was upregulated in clinical GC tissues and cell lines, and higher CARM1 expression predicted worse prognosis. CARM1 enhanced GC cell proliferation, facilitated G1-S transition and inhibited ER stress-induced apoptosis by regulating autophagy. Importantly, the treatment of CARM1 inhibitor rescued the tumor-promoting effects of CARM1 both in vitro and in vivo. Furthermore, we proved CARM1 heightened TFE3 nuclear translocation to induce autophagy via cytoplasmic AMPK-mTOR and nuclear CARM1-TFE3 signaling pathways.Conclusion: CARM1 promoted GC cell proliferation, accelerated G1-S transition and reduced ER stress-induced apoptosis by regulating autophagy. Mechanically, CARM1 triggered autophagy by facilitating TFE3 nuclear translocation via AMPK-mTOR and CARM1-TFE3 signaling pathways.