bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-nociceptive and anti-inflammatory effects of the hydroethanolic extract of a polyherbal preparation (Cov-Pla 2) in laboratory animals
Authors: Amagon Kennedy Iliya , Falang Kakjing Dadul , Bukar Bukata Bayero , Ajima Ukpe , Wannang Noel Nen’man , Kolawole Jacob Adegboyega , Damen James Garba , Agabi Yusuf Amuda , Kutshik Richard Joseph , Longdet Ishaya Yohanna LONGDET , Gomerep Simji Samuel , Shittu Ismaila , Davou Stephen Daniel 
Published: April 2021

Symptoms of Coronavirus Disease-2019 include pulmonary hyper-inflammation; managing local and systemic inflammatory responses may be key in treatment. This study evaluated the anti-inflammatory, analgesic and antipyretic effects of a mixture (Cov-Pla 2) containing five medicinal plants in laboratory animals. The antinociceptive activity of Cov-Pla 2 was evaluated using acetic acid-induced writhing, Brewer’s Yeast Pyrexia test in rats and hot plate tests in mice. The egg albumin-induced rat paw oedema test was employed to evaluate the extract’s anti-inflammatory activity. The extract produced a dose-dependent (125-500 mg/kg, p.o.) inhibition of pain response elicited by acetic acid, compared to normal saline and increased reaction latency in the hot plate test. The antiinflammatory test showed a significant (P<0.05) reduction in paw size diameter at 125 mg/kg from 2 hours, compared to control. In the antipyretic test, the extract produced a significant (P<0.05) time-dependent decrease in rectal temperature at 125 mg/kg after 2 and 3 hours and at 250 and 500 mg/kg after 3 hours, compared to normal saline. The extract did not produce mortality up to 5000 mg/kg per oral. The results indicated that the extract possesses antinociceptive and anti-inflammatory properties, which support its recommendation for trials in the treatment of symptoms associated with COVID-19.
Keywords: COVID-19; Inflammation; Nociception; Polyherbal; SARS-CoV-2
Stabilization potential of acidified corn starch in vitamin E enriched coconut oil emulsions for extemporaneous topical formulations
Authors: Adetunji Oladapo A. , Akingbade Tobilola O. 
Published: April 2021

In this study, the stabilizing potential of corn starch acidified with hydrochloric acid (ACS) in comparison with Tween 80® was evaluated in vitamin E enriched coconut emulsions for use in extemporaneous topical formulations. Emulsions containing vitamin E and coconut oil (2:3) as lipid phase and different concentrations (1.5 – 5.0 %w/w) of ACS (or Tween80®) in phosphate buffer as aqueous phase were formulated at 27± 2 ⁰C. , Droplet sizes and shapes, pH and rheological properties were evaluated. Acidified CS was analysed using FTIR spectroscopy Emulsions stabilized with ACS and Tween80® were cream and yellow coloured respectively, with the intensity of the colour increasing as the concentration increased. The emulsions were non-offensive and easily re-dispersed on shaking. Emulsions containing ACS had larger droplet sizes (18.34± 1.14 - 33.27± 1.32 µm) and were more spherically shaped with higher pH values(6.80-6.95), showing dilatant and pseudoplastic flows at low and high shear rates respectively. The viscosity of emulsions stabilized at 2.5 %w/w and 5.0 %w/w remained unchanged after seven days. Acidified corn starch has stabilizing potentials comparable with Tween 80® when incorporated in vitamin E enriched coconut oil emulsions for extemporaneous topical formulations.
Keywords: Coconut oil emulsions; Vitamin E; Acidified corn starch; Tween80®; Viscosity Emulsion stability, Extemporaneous topical formulations
Effects of core-stabilization and dynamic strengthening exercises on patients with non-specific chronic low back pain in Lagos: A pilot study
Authors: Akodu A.K. , Ajepe T.O. , Onwuazombe J.O. 
Published: April 2021

Objectives: Exercise is the most widely used form of treatment adopted for gaining relief from low back pain. But the efficacy of core stabilization and dynamic strengthening exercise on cardiopulmonary parameters of non-specific chronic low back pain patients needs to be established. This study therefore compared the effects of core stabilization and dynamic strengthening exercises on pain related disability and selected cardiopulmonary parameters in patients with non-specific chronic low back pain (NSCLBP).Methods: A total of 20 (44.55±10.78years) NSCLBP patients participated in this study. They were assigned into two different groups. Group A and B received core stabilization exercise and dynamic strengthening exercise respectively. Participants went through this protocol twice weekly for 4 consecutive weeks and were thereafter assessed for pain-related disability, and selected cardiopulmonary parameters.Results: The result of this study revealed that both exercises (core stabilization and dynamic) improved pain–related disability (p=0.011; p=0.004) and some cardiopulmonary parameters in peak expiratory flow rate (PEFR) (p= 0.001, P=0.034) and rate of perceived exertion (RPE) (P=0.001, P=0.001) Pulse rate (PR) (P=0.042, P=0.005).Conclusions: This study showed that both interventions (core stabilization and dynamic strengthening exercise) led to similar result in managing pain-related disability and selected cardiopulmonary parameters except in systolic blood pressure (SBP), Diastolic blood pressure (DBP) and peak expiratory flow rate (PEFR) in patients with NSCLBP when between groups comparison was done.
Keywords: Exercise, cardiopulmonary assessment, chronic low back pain, pilot study
Nigeria’s development process, methodology and milestones planned for VISION 20:2020 - 13 years after
Authors: Akinsorotan O.A. 
Published: April 2021

Protection of environment and sustainable natural resources
Nigeria is endowed with abundant human and natural resources, hence, her potential of becoming one the world's prosperous economy cannot be overemphasized. Despite the country's vision of becoming one of the world top 20 largest economies, Nigeria is yet to harness and utilized her endowments to transform her economy. Apparently Vision 2020 goals is not achievable in no distant future. This paper reviewed the level at which Nigeria is in the NV20:2020 plan and suggests measures necessary for the realization of the vision. Nigerian Government should recognise poverty eradication and sustainable management of natural resources as important factors that can propel a nation to the realm of wealthy economy.
Keywords: Nigeria, sustainable management, poverty eradication, Vision 2020
Nigeria’s development process, methodology and milestones planned for VISION 20:2020 - 13 years after
Authors: Hassan M.B. , Omobuwa O. 
Published: April 2021

A private sector-led economy
Aprivate sector led economy is the sine qua non of an egalitarian, capitalistic and welfare oriented society where every individual is free to develop and contribute to the national economy at their own pace and the individual's reward based on their productivity. However, this is only achievable where infrastructural facilities and support are optimal a situation that has been lacking in the country due to high cost of production; unfavourable business environment; lack of skilled manpower in the country; lack of adequate financial support and others. Opportunity for the government to provide a lead was adequately enunciated in the Nigeria Vision 20:2020 document but this has really not been met. This review as part of a series actually confirms this and will be a pointer to the way forward in enunciating future policy directions for the country
Estrategias de aprendizaje y rendimiento académico de los estudiantes de primer ingreso de la Universidad
Authors: Contreras Lémus Manuel Antonio 
Published: April 2021

El objetivo del artículo es dar a conocer los principales resultados de la investigación titulada estrategias de aprendizaje y rendimiento académico de los estudiantes de la universidad. El enfoque del estudio corresponde al método de investigación mixto, con un diseño que permite enmarcar un Diseño de Triangulación Concurrente (DITRIAC). Tiene un alcance descriptivo y correlacional, de manera simultánea se recolectaron y analizaron datos cuantitativos y cualitativos sobre el problema de investigación. El resultado más importante de la investigación, se obtuvo después de haber realizado las encuestas, entrevistas y observaciones, obteniéndose un 52% de estudiantes si conocen que son las estrategias de aprendizaje y un 50% creen que con el uso de las estrategias de aprendizaje se logra un buen rendimiento académico. Los estudiantes de primer ingreso de la universidad no han trabajado variedad de estrategias de aprendizaje por lo que necesitan reforzamiento constante en el uso de cada estrategia que se les asigne trabajar, se identifó que los estudiantes de primer ingreso de la universidad enfrentan dificultades porque son estrategias nuevas y anteriormente no han trabajado por lo que tienen una oportunidad de reforzar, evolucionar y tener una transformación constante que les ayude a trabajar de forma responsable pora obtener conocimientos actuales.
KAJIAN MANAJEMEN KRISIS PADA UPAYA PENCEGAHAN PENYEBARAN COVID-19 DALAM PEMILIHAN SERENTAK TAHUN 2020
Authors: Ali Jalaluddin 
Published: April 2021

Kajian ini bertujuan untuk merumuskan analisis manajemen krisis pada upaya pencegahan penyebaran Covid-19 dalam pemilihan serentak tahun 2020. Kajian ini bersifat deskriptif kualitatif, menggunakan metode kepustakaan. Mengumpulkan pendapat ahli tentang manajemen krisis dan beberapa regulasi terkait pemilu lalu kemudian dirangkum menjadi sebuah simpulan. Batasan masalah dalam kajian ini pertama aspek pelaksanaan tahapan pilkada dan kedua aspek kesehatan dan keselamatan. Hasil yang didapat dari kajian ini bahwa KPU akan menggelar Pilkada Serentak pada tahun 2020 dalam kondisi pandemi Covid-19. KPU menerapkan protokol pencegahan penyebaran Covid-19 pada setiap tahapan Pilkada Serentak tahun 2020. Kesimpulan kajian adalah bahwa pelaksanaan Pilkada Serentak tahun 2020 ditengah pandemi Covid-19 membutuhkan analisa manajemen krisis. Manajemen krisis ini mempertimbangkan aspek kesehatan dan keselamatan. Manajemen krisis diterapkan mulai dari tahap persiapan, tahap pelaksanaan sampai tahap pasca pilkada berlalu. Pada tahap persiapan, KPU secara khusus merumuskan kebijakan regulasi terkait pencegahan penyebaran covid-19. Protokol kesehatan wajib dilakukan. Penambahan anggaran untuk pembelian Alat Pelindung Diri (APD). Pada tahap pelaksanaan, terjadi penundaan tahapan karena pandemi. Jumlah Tempat Pemungutan Suara bertambah. Jumlah petugas bertambah. Pasca pilkada, pola dan metode pencegahan penyebaran Covid-19 yang diterapkan pada pilkada tahun 2020 menjadi model pada pelaksanaan pemilihan berikutnya.
Effect of Training Exercise Program on Functional Outcomes for Patients with Hand Burns
Authors: Ibrahim Rawia A. , Omran Eman S. M. 
Published: April 2021

Context: The outcome of hand burns can significantly impact daily function and overall health-related quality of life. A crucial issue in hand burns is proper management of hands treatment and care for maximizing the normal function of the burned hand.
Aim: To evaluate the effect of training exercise program on functional outcomes for patients with hand burns.
Methods: A quasi-experimental design (study/control group) was utilized to achieve the aim of this study. This study conducted at the burn unit at Benha Teaching Hospital. A purposive sample of 60 conscious adult patients who suffered from hand burns. They were divided equally into the study and control group, 30 patients in each. Two tools were used. The structured interview questionnaire to assess patients' knowledge regarding burn injury. Functional outcome scale involving: Jebson-Taylor hand function test (JTHFT) and observational checklist for assessing the hand’s range of motion.
Results: Showed that there was highly statistically significant improvement in patients’ knowledge score among the study group compared to control group, as well as there was an improvement in the function of hand and range of motion in the study group rather than in control group with highly statistically significant differences between both groups.
Conclusions: Implementing a designed training exercise program for patients with hand burns effectively improved knowledge, a function of the hand, and range of motion among the study group than in the control group. The study recommended that post-burn programs should be initiated by a multidisciplinary team and continued after discharge to provide support, education, prevention of complications, and motivation for burn patients.
MISI HOLISTIK:
Authors: Putra Adi , Salurante Tony 
Published: April 2021

Abstract: This research was conducted to provide a new understanding to the church about holistic mission, especially based on the description in the text of Luke 9: 1-6. By using qualitative methods, the researcher then found several principles about the holistic mission as the conclusion of this study. First, a holistic mission is a mission that is carried out through a mission and is a continuation of God's mission to Jesus. Second, a holistic mission is a mission carried out by the apostles and furthermore by the Church as a mandate from Jesus to provide significant social change or impact in the midst of society. Third, a holistic mission is a mission that focuses on a clear mission object and requires transformation or change. Fourth, a holistic mission is a mission that preaches the Kingdom of God. Fifth, "I send you into the world to preach the kingdom of God" is an expression of the great mission of the Son of God.
Abstrak: Penelitian ini dilakukan untuk memberikan pemahaman yang baru kepada gereja tentang misi yang holistik, khususnya berdasarkan uraian dalam teks Lukas 9:1-6. Dengan menggunakan metode kualitatif, peneliti kemudian menemukan beberapa prinsip tentang misi holistik sebagai kesimpulan dari penelitian ini. Pertama, misi yang holistik adalah misi yang dilakukan melalui sebuah pengutusan dan merupakan kelanjutan dari misi Allah kepada Yesus. Kedua, misi yang holistik adalah misi yang dilaksanakan oleh para rasul dan selanjutnya oleh Gereja sebagai amanat dari Yesus untuk memberikan perubahan atau dampak sosial yang signifikan di tengah-tengah masyarakat. Ketiga, misi yang holistik adalah misi yang fokus kepada sebuah objek misi yang jelas dan membutuhkan transformasi atau perubahan. Keempat, misi yang holistik adalah misi yang memberitakan tentang Kerajaan Allah. Kelima, “Ku utus Engkau ke dunia untuk memberitakan Kerajaan Allah” merupakan sebuah ungkapan misi yang begitu Agung dari Sang Anak Allah.
Scientific Approach to Celebrate Festivals in Maharashtra in India - A Conceptual Study
Authors: Dunghav Manisha G 
Published: April 2021

Festival celebration is an inseparable event from the lifestyle of Indians. This study is proposed to explain the scientific approach towards the Indian festivals to promote good health and to overcome the wrong beliefs of mythological stories to particular festivals.Indian cultureÂ is having great diversities in traditions and customs.It could be due to geographical distribution .Maharashtra also follow its own customs & traditions and celebrate festivals for the acceptance of this environmental changes to mentain sound health rather than follow rituals and beliefs on mythological stories.Â So, while celebrating festivals one should follow the regimen of ritu sandhi according to desha( land).
Root Cause of Diseases â€“ Ama Concept W.S.R to Free Radical Theory
Authors: Sapra Jaideep 
Published: April 2021

Ayurveda speaks the main cause of diseases is rooted in the impairment of the body's main fire, called Agni, the fire of digestion. Ayurveda views the health of the body as the functioning of a biological fire-governing metabolism. If this essential part is functioning effectively,Â the whole body will be nourished, full of life and vibrancy. Altered digestive functioning can lead to the production of Ama, a toxic material that initiates and promotes disease processes throughout the body. In the same way, free radicals are also found to be the root cause of many diseases. The majority of free radicals that damage biological systems are oxygen-free radicals, and these are more generally known as â€œReactive oxygen Speciesâ€ (ROS). These are the main byproducts formed in the cells of aerobic organisms, and can initiate autocatalytic reactions so that molecules to which they react are themselves converted into free radicals to propagate the chain of damage. Here we shall discuss about properties of both Ama and Free Radicals. The present article attempts to correlate the concept of Free radical with the concept of Ama.Â
Computation and Comparison of The Drug Efficacy Indices [Q(VPK)] of certain Ayurvedic Hair Care Formulations
Authors: Mullasserill Abhilash 
Published: April 2021

Â Â Â Â Â Â The Ayurveda being one of the oldest systems of alternative medicines have its roots in Rgveda the oldest monument of human civilization. Indian Rishis kept this system as their eyeball and developed many useful formulations to the entire human society. The present study aims to predict the efficacies of certain Hair Care Ayurvedic formulations including the modern patented and proprietary medicines by computing their respective Drug Efficacy Indices. The Drug Efficacy Index is a new concept that could be considered as the direct measure of efficacy of various Ayurvedic formulations.Â
A Comparative clinical study to evaluate the effect of Indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in Parinama Shoola Vis-Ã -vis Acid Peptic Disorders
Authors: Singhal Pragya 
Published: April 2021

Background: : Acid peptic disease is the condition in which there is either excessive secretion of acid and pepsin or a weakened stomach mucosal defence, which is responsible for damage to the delicate mucosa and the lining of the stomach, oesophagus and duodenum resulting in ulceration.Parinama shoola in Ayurveda is comparable with Acid peptic disease.Aim of study: The Aim of the study is to evaluate and compare the effect of indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in uncomplicated cases of Parinam shoola.Methods:Â This is a prospective, open labelled, randomised clinical trial. A total of 31 patients suggestive of features of Parinama Shoola (acid peptic disorder) were enrolled and were randomly divided in two groups- 12 patients were enrolled in group A and were given trial drug Shatavari mandoor,19 patients were enrolled in group B and were given trial drug Pippali ghrita. Duration of study was 3 months.Results: Individually both groups showed statistically significant improvement in clinical symptoms i.e. pain in abdomen, epigastric burning, nausea, flatulence, loss of appetite and constipation (p<0.01), but the mean reduction in the symptoms of group A (Shatavari mandoor group) is more than group B (Pippali ghrita group).Conclusion: Both trial drugs are effective in the treatment of Parinama shoola. Shatavari mandoor is more effective in the treatment of Parinam shoola in comparison to Pippali ghrita.Â
Arka and its pharmaceutical attributes in Indian alchemy (Rasashastra): A comprehensive review
Authors: Ranade Anagha Vishwas , Acharya Rabinarayan 
Published: April 2021

Rasashastra, a branch of Ayurvedic system of medicine, deals with the pharmaceutical procedures of drugs of metallic, mineral and poisonous origin. These drugs are processed by some unique prescribed pharmaceutical techniques including Shodhana (purification process), Jarana (incineration) and Marana (calcination) that renders them fit for internal administration. Some specific groups of drugs of herbal origin viz. Marak gana (group of calcifying herbs), Dugdha varga (group of latex bearing plants), etc. are used for these procedures which primly include medicinal plants.Arka, (Calotropis procera Ait. and Calotropis gigantea L.R.Br.) one of such plant from the semi-poisonous group finds manifold usage in these purification procedures and incineration techniques for many Rasaushadhis. Still, single hand information on the collective information regarding the use of Arka in various processing techniques in Rasashastra is deficient. Hence, a thorough review from available 37 texts related to Rasashastra was made and the necessary supplementary references of nano particles was found out through available resources from internet. After a critical analysis, a total of 133 references were found wherein the usage of Arka has been highlighted in different pharmaceutical processes in texts of Rasashastra. Among them, thirty eight are related to procedures of shodhana and marana of Parada (mercury), nineteen deal with procedures concerned with Maharasa, six and three respectively in case of Uparasa and Sadharana (mineral origin) rasa along with fifty five processing techniques ofÂ variedÂ dhatus (metals).Â
Clinical evaluation of Mustababbula churna and Takrarista In the management of Grahani
Authors: Bisht Yogita , Sushma Rajni 
Published: April 2021

Background: The disease in which Grahani or the small intestine gets vitiated and there is impairment of agni (digestive fire) is called Grahani. Anatomically Grahani is said to be situated above the umbilicus and between amashaya (stomach) and pakwashaya (intestines). Physiologically it holds the ingested food for the duration of its digestion before the undigested food residue is propelled into the pakwashaya (intestines).Â Aim of study: 1) To evaluate the efficacy of Mustababbula churna in the management of Grahani. 2) To evaluate the efficacy the Mustababbula churna and Takrarista in the management of Grahani. Methods: This is a prospective, randomized clinical trial. A total of 80 patients suggestive of features of Grahani roga were enrolled and were randomly divided into two groups- 40 patients each. Group A treated with Mustababbula churna and group B were given Mustababbula churna and Takrarista. The duration of study was 3 months. Results: Both the groups showed statistically significant results in clinical symptoms i.e. altered bowel movements, thirst, anorexia, nausea, blackouts, pain in bones and joints, sour eructations etc but the mean reduction in the symptoms of group B was more than group A. Conclusion:Â Mustababbula churna is very effective in the management of Grahani but when used with Takrarista it was more effective and also improved the state of agni (digestive fire).Â
ROLE OF AGNI VAISHAMYA IN CHRONIC PAIN PATHOLOGIES WITH SPECIAL REFERENCE TO NECK AND BACK PAIN- A CROSS SECTIONAL STUDY.
Authors: Edavalath Mukesh 
Published: April 2021

Chronic back and neck pain are common clinical entities in ayurvedic practice. Most of the patients are not rendered pain free with the current ayurvedic treatment regimens. Ayurveda considers agni (digestive power) derangements as the basic cause for all nija rogas (endogenous diseases). The term agnivaishamya is implied for functional derangement of agni. Emerging evidences through modern researches point to the role of GI dysfunctions in pain pathologies.Â A cross sectional analysis of patients with chronic pain in the neck and back was conducted at VPSV Ayurveda college hospital to explore associations between pain and features of agnivaishamya in koshta (GIT). In the twenty eight patients analyzed, significant association has been found between pain in low back and koshta (GIT) features like Arsas (hemorrhoids) and vibandha (Constipation). Strength of association was more between arsas and low back pain with OR Â of 4.2 (P<0.05). In the case of cervical pain , multiple features of Koshta like avipaka (feeling of indigestion), aruchi (anorexia), amlodgara (sour eructations), urodhumayana (chest burn) and muhurbadha muhurdrava pureesha (alternating constipation and loose stools) were found to be associated. Hence it can be concluded that there is significant association of agnivaishamya with chronic pain in neck and back.