bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Sleep Duration on Depression and Anxiety After Acute Ischemic Stroke
Authors: Liu Fei , Yang Yang , Wang Shuo , Zhang Xiao-Li , Wang An-Xin , Liao Xiao-Ling , Fang Hong-Juan , Qu Yue , Ma Wei-Guo , Zhang Ning , Wang Chun-Xue , Wang Yong-Jun 
Published: March 2021

Background: Abnormal sleep duration predicts depression and anxiety. We seek to evaluate the impact of sleep duration before stroke on the occurrence of depression and anxiety at 3 months after acute ischemic stroke (AIS).Methods: Nationally representative samples from the Third China National Stroke Registry were used to examine cognition and sleep impairment after AIS (CNSR-III-ICONS). Based on baseline sleep duration before onset of stroke as measured by using the Pittsburgh Sleep Quality Index (PSQI), 1,446 patients were divided into four groups: &gt;7, 6–7, 5–6, and &lt;5 h of sleep. Patients were followed up with the General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) for 3 months. Poststroke anxiety (PSA) was defined as GAD-7 of ≥5 and poststroke depression (PSD) as PHQ-9 of ≥5. The association of sleep duration with PSA and PSD was evaluated using multivariable logistic regression.Results: The incidences of PSA and PSD were 11.2 and 17.6% at 3 months, respectively. Compared to a sleep duration of &gt;7 h, 5–6 h, and &lt;5 h of sleep were identified as risk factors of PSA [odds ratio (OR), 1.95; 95% confidence interval (CI), 1.24–3.07; P &lt; 0.01 and OR, 3.41; 95% CI, 1.94–6.04; P &lt; 0.01) and PSD (OR, 1.47; 95% CI, 1.00–2.17; P = 0.04 and OR, 3.05; 95% CI, 1.85–5.02; P &lt; 0.01), while 6–7 h of sleep was associated with neither PSA (OR, 1.09; 95% CI, 0.71–1.67; P = 0.68) nor PSD (OR, 0.92; 95% CI, 0.64–1.30; P = 0.64). In interaction analysis, the impact of sleep duration on PSA and PSD was not affected by gender (P = 0.68 and P = 0.29, respectively).Conclusions: Sleep duration of shorter than 6 h was predictive of anxiety and depression after ischemic stroke.
Amantadine ER (Gocovri®) Significantly Increases ON Time Without Any Dyskinesia: Pooled Analyses From Pivotal Trials in Parkinson's Disease
Authors: Hauser Robert A. , Walsh Ryan R. , Pahwa Rajesh , Chernick Dustin , Formella Andrea E. 
Published: March 2021

Background: Clinical trials for antiparkinsonian drugs aimed at managing motor complications typically use patient diaries to divide levodopa-induced dyskinesias (LID) into “troublesome” and “non-troublesome” categories. Yet, given the choice, most patients would prefer to live without experiencing any dyskinesia. However, the concept of evaluating time spent ON without any dyskinesia as an outcome has never been tested. We conducted analyses of pooled Gocovri pivotal trial data in order to evaluate the extent to which Gocovri increased the time PD patients spent ON without dyskinesia (troublesome or non-troublesome), beyond its already identified improvement in reducing troublesome dyskinesia.Methods: Patients enrolled in phase 3 trials (EASE LID [NCT02136914] or EASE LID 3 [NCT02274766]) recorded time spent in the following PD diary states at baseline and Week 12 (endpoint): asleep, OFF, ON with troublesome dyskinesia, ON with non-troublesome dyskinesia, and ON without dyskinesia. Mixed model repeated measures analyses with estimated Cohen D effect sizes were performed on the modified intent to treat population to evaluate changes in time spent in these states.Results: Patients randomized to receive Gocovri showed an increase in ON time without dyskinesia and corresponding decreases in ON time with dyskinesia and OFF time vs. placebo. Treatment effects were statistically significant for Gocovri vs. placebo starting at Week 2 and were sustained until Week 12. On MMRM analysis at Week 12, patients in the Gocovri group showed an adjusted mean ± SE increase over placebo of 2.9 ± 0.6 h in ON time without dyskinesia (Cohen D effect size 0.79) and an adjusted mean ± SE decrease of −1.9 ± 0.6 h in ON time with dyskinesia (troublesome + non-troublesome) (Cohen D effect size 0.49), that included a −1.5 ± 0.4 h placebo-adjusted reduction in ON time with troublesome dyskinesia and a −0.6 ± 0.4 h reduction in ON time with non-troublesome dyskinesia. OFF time was reduced by −1.0 ± 0.3 h compared to placebo.Conclusions: Gocovri treatment more than doubled the daily time patients spent ON without dyskinesia. These results suggest that the Gocovri treatment effect was driven by a reduction in overall motor complications including ON time with both troublesome and non-troublesome dyskinesia as well as time spent OFF.
C-Gait for Detecting Freezing of Gait in the Early to Middle Stages of Parkinson’s Disease: A Model Prediction Study
Authors: Chen Zi-Yan , Yan Hong-Jiao , Qi Lin , Zhen Qiao-Xia , Liu Cui , Wang Ping , Liu Yong-Hong , Wang Rui-Dan , Liu Yan-Jun , Fang Jin-Ping , Su Yuan , Yan Xiao-Yan , Liu Ai-Xian , Xi Jianing , Fang Boyan 
Published: March 2021

Graphical AbstractPatients with early- to middle-stage PD (Hoehn and Yahr stages 1–3) were enrolled for C-Gait assessment and traditional walking ability assessments. The correlation of C-Gait assessment and traditional walking tests were studied. Two models were established based on C-Gait assessment and traditional walking tests to explore the value of C-Gait assessment in predicting freezing of gait.
Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases
Authors: Yang Dalin , Shin Yong-Il , Hong Keum-Shik 
Published: March 2021

BackgroundBrain disorders are gradually becoming the leading cause of death worldwide. However, the lack of knowledge of brain disease’s underlying mechanisms and ineffective neuropharmacological therapy have led to further exploration of optimal treatments and brain monitoring techniques.ObjectiveThis study aims to review the current state of brain disorders, which utilize transcranial electrical stimulation (tES) and daily usable noninvasive neuroimaging techniques. Furthermore, the second goal of this study is to highlight available gaps and provide a comprehensive guideline for further investigation.MethodA systematic search was conducted of the PubMed and Web of Science databases from January 2000 to October 2020 using relevant keywords. Electroencephalography (EEG) and functional near-infrared spectroscopy were selected as noninvasive neuroimaging modalities. Nine brain disorders were investigated in this study, including Alzheimer’s disease, depression, autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, Parkinson’s disease, stroke, schizophrenia, and traumatic brain injury.ResultsSixty-seven studies (1,385 participants) were included for quantitative analysis. Most of the articles (82.6%) employed transcranial direct current stimulation as an intervention method with modulation parameters of 1 mA intensity (47.2%) for 16–20 min (69.0%) duration of stimulation in a single session (36.8%). The frontal cortex (46.4%) and the cerebral cortex (47.8%) were used as a neuroimaging modality, with the power spectrum (45.7%) commonly extracted as a quantitative EEG feature.ConclusionAn appropriate stimulation protocol applying tES as a therapy could be an effective treatment for cognitive and neurological brain disorders. However, the optimal tES criteria have not been defined; they vary across persons and disease types. Therefore, future work needs to investigate a closed-loop tES with monitoring by neuroimaging techniques to achieve personalized therapy for brain disorders.
Rationalizing the Role of Monosodium Glutamate in the Protein Aggregation Through Biophysical Approaches: Potential Impact on Neurodegeneration
Authors: Ahanger Ishfaq Ahmad , Bashir Sania , Parray Zahoor Ahmad , Alajmi Mohamed F. , Hussain Afzal , Ahmad Faizan , Hassan Md. Imtaiyaz , Islam Asimul , Sharma Anurag 
Published: March 2021

GRAPHICAL ABSTRACT 1Kinetic measurements indicating that monosodium glutamate causes significant enhancement of aggregation of protein through nucleation-dependent polymerization mechanism. Even low concentration of MSG is involved in the unfolding of secondary structure of protein with the disappearance of original peaks (208 and 222 nm) and formation of unique peak (226 nm) in the far-UV CD.
It Takes a Team to Make It Through: The Role of Social Support for Survival and Self-Care After Allogeneic Hematopoietic Stem Cell Transplant
Authors: Song Yaena , Chen Stephanie , Roseman Julia , Scigliano Eileen , Redd William H. , Stadler Gertraud 
Published: March 2021

BackgroundSocial support plays an important role for health outcomes. Support for those living with chronic conditions may be particularly important for their health, and even for their survival. The role of support for the survival of cancer patients after receiving an allogeneic hematopoietic cell transplant (alloHCT) is understudied. To better understand the link between survival and support, as well as different sources and functions of support, we conducted two studies in alloHCT patients. First, we examined whether social support is related to survival (Study 1). Second, we examined who provides which support and which specific support-related functions and tasks are fulfilled by lay caregivers and healthcare professionals (Study 2).MethodsIn Study 1, we conducted a retrospective chart review of alloHCT patients (N = 173, 42.8% female, age: M = 49.88) and registered availability of a dedicated lay caregiver and survival. In Study 2, we prospectively followed patients after alloHCT (N = 28, 46.4% female, age: M = 53.97, 46.4% ethnic minority) from the same hospital, partly overlapping from Study 1, who shared their experiences of support from lay caregivers and healthcare providers in semi-structured in-depth interviews 3 to 6 months after their first hospital discharge.ResultsPatients with a dedicated caregiver had a higher probability of surviving to 100 days (86.7%) than patients without a caregiver (69.6%), OR = 2.84, p = 0.042. Study 2 demonstrated the importance of post-transplant support due to patients’ emotional needs and complex self-care regimen. The role of lay caregivers extended to many areas of patients’ daily lives, including support for attending doctor’s appointments, managing medications and financial tasks, physical distancing, and maintaining strict dietary requirements. Healthcare providers mainly fulfilled medical needs and provided informational support, while lay caregivers were the main source of emotional and practical support.ConclusionThe findings highlight the importance of studying support from lay caregivers as well as healthcare providers, to better understand how they work together to support patients’ adherence to recommended self-care and survival.
PENDIDIKAN KEWIRAUSAHAAN BERWAWASAN GENDER BAGI PENGELOLA UNIT USAHA BUMDES DESA KARANG BUNGA, KECAMATAN MANDASTANA, KABUPATEN BATOLA-KALSEL
Authors: Nurhikmah Nurhikmah , Rusvitawati Devi , Heryawan Firda Rezky , Chumaidi Chumaidi , Mia Mia , Agustina Tiara 
Published: March 2021

A Gender-Based Entrepreneurship Education for BUMDes administrators of Karang Bunga Village, Mandastana District, Barito Kuala in South Kalimantan. This activity aims to build the community empowerment, especially women in the economic field through the growth and development of skills activities so that they have the ability and competitiveness in employment and economic ventures. The PRA (Participatory Rulai Apraisah) method had been used in implementing this activity. The results reveal that some people of Karang Bunga Village, Mandastana District, Barito Kuala in South Kalimantan, especially women have basic skills about entrepreneurship as the basic capital to find work or open a new business, and there is a community formation to open new businesses based on local potentials with a gender perspective.
PELATIHAN PEMBELAJARAN DARING DIMASA PANDEMI COVID-19 UNTUK GURU- GURU SD NEGERI 3 MELAYU MUARA TEWEH
Authors: Azizah Aulia 
Published: March 2021

COVID-19 telah ditetapkan sebagai pandemi global dan memaksa pemerintah mengeluarkan aturan bagi guru-guru dan siswa untuk melakukan pembelajaran dari rumah yaitu melakukan pembelajaran secara online atau pembelajaran daring. Banyaknya guru-guru yang tidak menguasai media digital membuat pembelajaran dari cukup menyulitkan dan melihat hal tersebut dirasa perlunya dilakukan pelatihan bagi para guru-guru agar mereka bisa memperoleh kemudahan dalam melakukan pembelajaran daring. Tujuan Kegiatan Pengabdian Kepada Masyarakat ini adalah untuk melatih Guru-Guru pada SD Negeri 3 Melayu Muara Teweh Mampu melaksanakan pembelajaran daring dengan media sederhana seperti grup di media sosial WhatsApp (WA), telegram, aplikasi zoom dan Google classroom. Lokasi Pengabdian Kepada masyarakat ini pada SD Negeri 3 Melayu Muara Teweh, Kabupaten Barito Utara, Kalimantan Tengah. Pelaksanaan kegiatan ini dari persiapan hingga pelaporan dilakukan selama 1 bulan yang dimulai pada awal bulan juni 2020 sampai 30 juni 2020. Tim PKM telah berhasil melakukan kegiatan pelatihan dengan lancar pada SDN 3 Melayu Muara Teweh.Guru-guru pada SDN 3 Melayu Muara Teweh sudah bisa melakukan pembelajaran daring dengan memanfaatkan media sosial yang ada dan melakukan video conference dengan aplikasi Zoom dan google classroom. Guru-guru SDN 3 Melayu Muara Teweh sangat antusias melakukan pelatihan yang diberikan oleh pemateri.
PENYULUHAN PENDAMPINGAN DALAM MENGHITUNG HARGA POKOK PRODUKSI TELUR AYAM PETELUR DI DESA JELAI KECAMATAN TAMBANG ULANG PELAIHARI
Authors: Gerhana Wida , Anwar Mahfuzil , Wahab Abdul , Yasrie Arfie 
Published: March 2021

Permasalahan saat ini dihadapkan bahwa peternak hanya mencatat jumlah uang yang diterima dan dikeluarkan, jumlah barang yang dijual, dan jumlah piutang/utang. Namun pencatatan itu hanya sebatas pengingat saja. Serta juga ditemukan bahwa ada sebagian dari biaya nonproduksi dimasukkan dalam biaya produksi. Besarnya biaya yang dikeluarkan untuk memproduksi telur, akan mempengaruhi harga pokok dari usaha peternakan. Semakin besar biaya yang dikeluarkan atau dikorbankan dalam memproduksi telur, maka harga produk yang dihasilkan akan semakin tinggi. Pengabdian masyarakat ini bertujuan untuk menganalisis perhitungan harga pokok produksi telur ayam yang benar dengan akuntansi yang ada. Pengabdian ini dilakukan di Peternakan Ayam Petelur yang terletak di Desa Sei Jelai, Kecamatan Tambang Ulang Pleihari, Kabupaten Tanah laut , Provinsi Kal-Sel. Pemilihan lokasi dilakukan dengan sengaja oleh Tim Pengabdian dengan pertimbangan bahwa peternakan tersebut merupakan perternakan yang memiliki skala usaha yang memadai. Pengabdian kepada masyarakat ini dilaksanakan pada bulan November 2019 . Sebelum pelaksanaan pengabdian masyarakat , peneliti terlebih dahulu melakukan survey tempat lokasi dengan mengamati sekilas kegiatan peternakan ayam petelur dan melakukan wawancara dengan pihak pemilik peternakan sekaligus dengan pekerja lapangan. Selama ini peternak hanya melakukan perhitungan harga pokok produksi lewat pencatatan biaya saja dan hanya melakukan harga pasar sehingga harga pokok produksi Perhitungan peternak termasuk keliru. Berdasarkan hasil perhitungan pada Peternakan Ayam Petelur sei jelai ini dengan metode full costing, diperoleh harga pokok produksi per Kilo Gram telur sebesar Rp. 14.181,- Dan dari hasil perhitungan menjadi acuan peternak untuk melakukan pencatatan biaya dengan baik dan menghasilkan harga pokok produksi yang sebenarnya.
Pengaruh Praktek Pengelolaan Sumber Daya Manusia dan Motivasi Kerja terhadap Kinerja Koperasi Melalui Partisipasi Anggota di Koperasi Setia Budi Wanita Malang
Authors: Insyiah Choirul , Respati Harianto , Sunardi Sunardi 
Published: March 2021

Penelitian ini dilakukan untuk mengungkapkan pengaruh pengelolaan sumberdaya manusia dan motivasi kerja terhadap partisipasi anggota yang berdampak kepada kinerja koperasi. Desain Penelitian ini adalah penelitian kuantitatif. Jenis data yang digunakan berasal dari jawaban responden sebanyak 75 anggota koperasi. Teknik analisis data menggunakan analisis deskriptif (Mean) dan Struktural Equation Model yang diselesaiakan dengan program SPSS. Hasil penelitian ini membuktikan bahwa pengelolaan sumber daya manusia dan motivasi kerja berpengaruh signifikan terhadap partisipasi anggota. Pengelolaan sumber daya manusia dan motivasi kerja berpengaruh signifikan terhadapkinerja koperasi. Partisipasi anggota berpengaruh signifikan terhadap kinerja koperasi. Artinya partisipasi anggota menjadi kunci keberhasilan dalam upaya meningkatkan kinerja koperasi terkait dengan implementasi tatakelola sumberdaya manusia dan motivasi kerja anggota koperasi.Kata Kunci : Pengelolaan sumber daya manusia, motivasi, partispasi anggota, kinerja koperasi.
Implementasi Kebijakan Adiwiyata dalam Pengelolaan Lingkungan Sekolah Menengah Atas Negeri 4 Kupang
Authors: Manobe Junindi Mandalika , Arjana I Gusti Bagus , Se Robertus 
Published: March 2021

Penelitian ini bertujuan untuk menjelaskan kebijakan sekolah Adiwiyata dalam pengelolaan lingkungan sekolah SMA Negeri 4 Kupang. Pada penelitian ini digunakan metode penelitian deskriptif kualitatif. Teknik analisis data menggunakan beberapa tahapan yaitu Pengumpulan data, Reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa, kebijakan sekolah Adiwiyata yang diterapkan dalam pengelolaan lingkungan sekolah Menengah Atas Negeri 4 Kupang, yakni adanya perubahan visi, misi dan tujuan yang berwawasan lingkungan yakni “Berprestasi, Berkarakter, Berwawasan Imtaq dan IPTEK serta berwawasan lingkungan. Selain itu, dalam setiap mata pelajaran selalu dikaitkan dengan isu lingkungan yang sedang terjadi. Hal tersebut didukung dengan mewajibkan guru dan pegawai untuk tetap memotivasi dan mengarahkan siswa untuk menumbuh kembangkan sikap peduli lingkungan, melalui pembelajaran, kerja bakti, seminar maupun sosialisasi serta turut berpartisipasi dalam aksi lingkungan. Selain itu, adanya kebijakan untuk mendaur ulang sampah organik maupun anorganik sebagai kreatifitas dan juga memannfaatkan pengolahan air dengan baik untuk pengelolaan lingkungan sekolah yang bersih dan sehat, semuanya disampaikan melalui himbauan secara langsung maupun tidak langsung (melalui papan himbauan). Dalam mendukung pelaksanaan program Adiwiyata, maka pihak sekolah mengalokasikan dana untuk kegiatan berbasis lingkungan, seperti untuk kegiatan kesiswaan, ekstrakurikuler, aksi lingkungan, seminar dan sosialisasi.
Urban housing in Iraq between funding policies and absence of strategies
Authors: Jassem Jabo Assist. Prof. Dr. Entezar , Jassim Dr. Shorouq Naeem 
Published: March 2021

The funding of the very important elements in the housing and that the weakness of this element or poor planning has caused slowing and sometimes stop in performance in the housing sector, where is the cost of the housing unit of the main obstacles to housing projects.Funding is the cornerstone of housing policy in general and the associated housing policy success in finding the appropriate channels and ports in providing funding for individuals and institutions involved in securing housing under proper conditions, and especially the limited cost of housing. Over the urban and residential development in Iraq at different stages which forms numerous state's handling of reality residential and according to political, economic and social developments and financial resources available to them which reflects the basic funding policies pursued by the state in Iraq, and is divided into two terms first before 2003, and the second after that
The research aims to assess the urban housing policies in Iraq since 1950 and through contracts the seventies and eighties and nineties up to the post in 2003 to shed light on those financial policies pursued by the State to support housing projects to alleviate the housing crisis in Iraq during that time period that stretched to more than half a century, however, the housing crisis in Iraq is worsening until I got to the stage of acute crisis, which requires the establishment of nearly 2.8 million housing units, according to the economic development of the plan estimates (2010-2014), while its housing policy up to 2 million units residential.
The Psychosocial Trends Of Neonatal Mothers Towards The Treatment Of Doctors And Midwives In The Hospital Field Study On A Sample Of Newborn Mothers In Biskra Cit
Authors: Bin Amer Dr. Waseela , Biwaeamar A. sahilat , Ebrahimi A. Kawther 
Published: March 2021

This study aimed to detect the psychosocial trends of the newly born mothers towards the treatment of the doctors and the midwives in the hospital institution in Biskra and to detect any statistically significant differences in this according to the variables (type of birth: normal / caesarean, number of births, number of days spent in hospital, state of the newborn: alive / dead, educational level, job). In order to achieve the objectives of the study, we used the descriptive method in its comparative method, and the measure was built on the five-year Likert method to measure the psychosocial trends of the newly born mothers (19 mothers).
- The newly born mothers have a negative psychosocial attitudes towards the treatment of midwives, and a positive treatment of the doctors in the hospital.
- There are no statistically significant differences in the psychosocial trends of the newly born mothers towards the treatment of the midwives in the hospital institution due to the variable (type of birth: normal / caesarean). Where there are statistically significant differences in the treatment of the doctors due to the variable of birth type and Caesarean section.
- There are no statistically significant differences in the psychosocial trends of newly born mothers towards the treatment of the midwives and the doctors due to the variable (number of births, number of days spent in hospital, state of the newborn: alive / dead, educational level, job
ФОРМУВАННЯ КОМПЕТЕНТНОСТЕЙ УЧАСНИКІВ ОСВІТНЬОГО ПРОЦЕСУ НА ОСНОВІ ХМАРО ОРІЄНТОВАНИХ ІНФОРМАЦІЙНО-ОСВІТНІХ СИСТЕМ
Authors: Биков Валерій Юхимович 
Published: March 2021

Представлено основні результати виконання комплексу наукових досліджень, що здійснювалися у 2018-2020 рр. в Інституті інформаційних технологій і засобів навчання НАПН України, з проблем формування компетентностей учасників освітнього процесу на основі хмаро орієнтованих інформаційно-освітніх систем: 1. «Адаптивна хмаро орієнтована система навчання та професійного розвитку вчителів закладів загальної середньої освіти» (фундаментальне, керівник — д-р пед. наук, с.н.с. М.П. Шишкіна); 2. «Система комп’ютерного моделювання пізнавальних завдань для формування компетентностей учнів з природничо-математичних предметів» (фундаментальне, керівник — д-р пед. наук, с.н.с. С.Г. Литвинова); 3. «Методика використання відкритих електронних науково-освітніх систем для розвитку інформаційно-дослідницької компетентності наукових і науково-педагогічних працівників» (прикладне, керівники — канд. пед. наук, с.н.с. А.В. Яцишин, канд. пед. наук С.М. Іванова). Особливу увагу в доповіді приділено впровадженню результатів досліджень у практику закладів загальної середньої освіти, вищої та післядипломної педагогічної освіти. Презентовано розроблені та апробовані на практиці методики, навчально-методичні матеріали. Системоутворювальними чинниками комплексу наукових досліджень є: загальна мета, єдиний базовий методологічний фундамент досліджень (системний, компетентнісний і проєктний підходи), комплексний характер їх одночасного проведення і впровадження, взаємозумовленість основних кінцевих результатів (сформованих цифрових компетентностей учасників освітнього процесу), хмарна комп’ютерно-технологічна платформа досліджень і реалізацій освітніх застосувань.