bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Grandfather in the Bones”
Authors: Hughes Rebecca C. 
Published: April 2021

Abstract
Evangelical Anglicans of the Church Missionary Society constructed a triumphal narrative on the growth of the Ugandan Church circa 1900–1920. This narrative developed from racial theory, the Hamitic hypothesis, and colonial conquest in its admiration of Ugandans. When faced with closing the mission due to its success, the missionaries shifted to scientific racist language to describe Ugandans and protect the mission. Most scholarship on missionaries argues that they eschewed scientific racism due to their commitment to spiritual equality. This episode reveals the complex ways the missionaries wove together racial and theological ideas to justify missions and the particularity of Uganda.
The observed North Equatorial Counter Current in the far western Pacific Ocean during the 2014-2016 El Niño
Authors: Zhou Hui , Liu Hengchang , Tan Shuwen , Yang Wenlong , Li Yao , Liu Xueqi , Ren Qiang , Dewar William K. 
Published: April 2021

AbstractThe structure and variations of the North Equatorial Counter Current (NECC) in the far western Pacific Ocean during 2014-2016 are investigated using repeated in-situ hydrographic data, altimeter data, Argo data, and reanalysis data. The NECC shifted ~1 degree southward and intensified significantly with its transport exceeding 40 Sv (1 Sv = 106 m3 s-1), nearly double its climatology value, during the developing phase of the 2015/16 El Niño event. Observations show that the 2015/16 El Niño exerted a comparable impact on the NECC with that of the extreme 1997/98 El Niño in the far western Pacific Ocean. Baroclinic instability provided the primary energy source for the eddy kinetic energy (EKE) in the 2015/16 El Niño, which differs from the traditional understanding of the energy source of EKE as barotropic instability in low latitude ocean. The enhanced vertical shear and the reduced density jump between the NECC layer and the subsurface North Equatorial Subsurface Current (NESC) layer renders the NECC–NESC system baroclinically unstable in the western Pacific Ocean during El Niño developing phase. The eddy-mean flow interactions here are diverse associated with various states of the El Niño Southern Oscillation (ENSO).
Challenges for the Implementation of the Rights of Nature: Ecuador and Bolivia as the First Instances of an Expanding Movement
Authors: Berros María Valeria 
Published: April 2021

The recognition of the rights of nature is currently being debated in the juridical, sociological, and ethical fields. In Ecuador and Bolivia the recognition of the rights of Pachamama (Mother Earth) began in the context of constitutional and legal amendments more than a decade ago. This process was articulated with proposals presented as alternatives to global capitalism related to the indigenous worldviews known as buen vivir or vivir bien. An exploration of these processes identifies a number of challenges to socio-legal research and points to the increasing acknowledgment of the rights of nature in various countries in Latin America and other parts of the world. Actualmente se debate el reconocimiento de los derechos de la naturaleza en los ámbitos jurídico, sociológico y ético. En Ecuador y Bolivia el reconocimiento de los derechos de la Pachamama (Madre Tierra) comenzó en el contexto de las enmiendas constitucionales y legales hace más de una década. Este proceso se articuló con propuestas presentadas como alternativas al capitalismo global y relacionadas con las cosmovisiones indígenas conocidas como buen vivir o vivir bien. Una exploración de estos procesos identifica una serie de desafíos a la investigación socio-legal y apunta al creciente reconocimiento de los derechos de la naturaleza en varios países de América Latina, así como otras partes del mundo.
Left orbital compartment syndrome and right anterior ischemic optic neuropathy in a patient with severe burns despite non-aggressive fluid resuscitation
Authors: Pircher Achmed , Holm Sebastian , Huss Fredrik 
Published: April 2021

Introduction: Ophthalmological complications such as orbital compartment syndrome (OCS) and ischemic optic neuropathy are rare complications in patients with burns and have been described in patients where aggressive fluid resuscitation was performed. While OCS requires urgent surgical intervention, no current treatment is established to treat, or prevent, ischemic optic neuropathy in patients with burns. Methods: The authors report a case of a 38-year-old woman with flame burns including the periorbital regions who developed OCS on the left side and anterior ischemic optic neuropathy (AION) on the right side despite non-aggressive fluid resuscitation. Immediate lateral canthotomy combined with inferior cantholysis was performed on the left side. Discussion and Conclusion: OCS and AION need to be considered as potential complications even in critically ill patients with facial burns who do not receive aggressive fluid resuscitation. Whether an early surgical intervention will lower the risk of AION development is, however, speculative. Lay Summary Ophthalmological complications such as orbital compartment syndrome and ischemic optic neuropathy are rare complications in patients with burns and have been described in patients where aggressive fluid resuscitation was performed. We present a case of a critically ill patient with severe facial burns who developed orbital compartment syndrome on the left side and anterior ischemic optic neuropathy on the right side even though our patient did not receive aggressive fluid resuscitation. Our case is particular because both of these rare complications are seen in a single patient and neither received aggressive fluid resuscitation. The fact that the patient did not develop ischemic optic neuropathy on the side where the lateral canthotomy was performed (only on the side where the patient had orbital compartment syndrome), this case might raise the discussion of whether an early surgical intervention might lower the risk of ischemic optic neuropathy development in patients with facial burns.
The prevalence and related factors of fatigue in patients with COPD: a systematic review
Authors: Ebadi Zjala , Goërtz Yvonne M.J. , Van Herck Maarten , Janssen Daisy J.A. , Spruit Martijn A. , Burtin Chris , Thong Melissa S.Y. , Muris Jean , Otker Jacqueline , Looijmans Milou , Vlasblom Christel , Bastiaansen Joëlle , Prins Judith , Wouters Emiel F.M , Vercoulen Jan H. , Peters Jeannette B. 
Published: April 2021

BackgroundFatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD.MethodsPubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings “COPD” and “Fatigue”. Studies were reviewed in accordance with PRISMA guidelines.Results196 studies were evaluated. The prevalence of fatigue ranged from 17–95%. Age (r=−0.23 to r=0.27), sex (r=0.11), marital status (r=−0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=−0.55 to r=−0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=−0.78 to r=−0.45), functional capacity (r=−0.77 to r=−0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue.ConclusionsFatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue.Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.
The molecular signatures of compatible and incompatible pollination in Arabidopsis
Authors: Kodera Chie , Just Jérémy , Da Rocha Martine , Larrieu Antoine , Riglet Lucie , Legrand Jonathan , Rozier Frédérique , Gaude Thierry , Fobis-Loisy Isabelle 
Published: April 2021

AbstractBackgroundFertilization in flowering plants depends on the early contact and acceptance of pollen grains by the receptive papilla cells of the stigma. Deciphering the specific transcriptomic response of both pollen and stigmatic cells during their interaction constitutes an important challenge to better our understanding of this cell recognition event.ResultsHere we describe a transcriptomic analysis based on single nucleotide polymorphisms (SNPs) present in twoArabidopsis thalianaaccessions, one used as female and the other as male. This strategy allowed us to distinguish 80% of transcripts according to their parental origins. We also developed a tool which predicts male/female specific expression for genes without SNP. We report an unanticipated transcriptional activity triggered in stigma upon incompatible pollination and show that following compatible interaction, components of the pattern-triggered immunity (PTI) pathway are induced on the female side.ConclusionsOur work unveils the molecular signatures of compatible and incompatible pollinations both at the male and female side. We provide invaluable resource and tools to identify potential new molecular players involved in pollen-stigma interaction.
Transcriptome architecture reveals genetic networks of bolting regulation in spinach
Authors: Abolghasemi Reza , Haghighi Maryam , Etemadi Nematollah , Wang Shui , Soorni Aboozar 
Published: April 2021

Abstract
Background
Bolting refers to the early flowering stem production on agricultural and horticultural crops before harvesting. Indeed, bolting is an event induced by the coordinated effects of various environmental factors and endogenous genetic components, which cause a large reduction in the quality and productivity of vegetable crops like spinach. However, little is known about the signaling pathways and molecular functions involved in bolting mechanisms in spinach. The genetic information regarding the transition from vegetative growth to the reproductive stage in spinach would represent an advantage to regulate bolting time and improvement of resistant cultivars to minimize performance loss.

Results
To investigate the key genes and their genetic networks controlling spinach bolting, we performed RNA-seq analysis on early bolting accession Kashan and late-bolting accession Viroflay at both vegetative and reproductive stages and found a significant number of differentially expressed genes (DEGs) ranging from 195 to 1230 in different comparisons. These genes were mainly associated with the signaling pathways of vernalization, photoperiod/circadian clock, gibberellin, autonomous, and aging pathways. Gene ontology analysis uncovered terms associated with carbohydrate metabolism, and detailed analysis of expression patterns for genes of Fructose-1, 6-bisphosphate aldolase, TREHALOSE-6-PHOSPHATE SYNTHASE 1, FLOWERING PROMOTING FACTOR 1, EARLY FLOWERING, GIGANTEA, and MADS-box proteins revealed their potential roles in the initiating or delaying of bolting.

Conclusion
This study is the first report on identifying bolting and flowering-related genes based on transcriptome sequencing in spinach, which provides insight into bolting control and can be useful for molecular breeding programs and further study in the regulation of the genetic mechanisms related to bolting in other vegetable crops.
A prediction model using machine-learning algorithm for assessing intrathecal hyperbaric bupivacaine dose during cesarean section
Authors: Wei Chang-na , Wang Li-ying , Chang Xiang-yang , Zhou Qing-he 
Published: April 2021

Abstract
Background
The intrathecal hyperbaric bupivacaine dosage for cesarean section is difficult to predetermine. This study aimed to develop a decision-support model using a machine-learning algorithm for assessing intrathecal hyperbaric bupivacaine dose based on physical variables during cesarean section.

Methods
Term parturients presenting for elective cesarean section under spinal anaesthesia were enrolled. Spinal anesthesia was performed at the L3/4 interspace with 0.5% hyperbaric bupivacaine at dosages determined by the anesthesiologist. A spinal spread level between T4-T6 was considered the appropriate block level. We used a machine-learning algorithm to identify relevant parameters. The dataset was split into derivation (80%) and validation (20%) cohorts. A decision-support model was developed for obtaining the regression equation between optimized intrathecal 0.5% hyperbaric bupivacaine volume and physical variables.

Results
A total of 684 parturients were included, of whom 516 (75.44%) and 168 (24.56%) had block levels between T4 and T6, and less than T6 or higher than T4, respectively. The appropriate block level rate was 75.44%, with the mean bupivacaine volume [1.965, 95%CI (1.945,1.984)]ml. In lasso regression, based on the principle of predicting a reasonable dose of intrathecal bupivacaine with fewer physical variables, the model is “Y=0.5922+ 0.055117* X1-0.017599*X2” (Y: bupivacaine volume; X1: vertebral column length; X2: abdominal girth), with λ 0.055, MSE 0.0087, and R2 0.807.

Conclusions
After applying a machine-learning algorithm, we developed a decision model with R2 0.8070 and MSE due to error 0.0087 using abdominal girth and vertebral column length for predicting the optimized intrathecal 0.5% hyperbaric bupivacaine dosage during term cesarean sections.
Chronic polytherapy after myocardial infarction: the trade-off between hospital and community-based providers in determining adherence to medication
Authors: Di Martino Mirko , Alagna Michela , Lallo Adele , Gilmore Kendall Jamieson , Francesconi Paolo , Profili Francesco , Scondotto Salvatore , Fantaci Giovanna , Trifirò Gianluca , Isgrò Valentina , Davoli Marina , Fusco Danilo 
Published: April 2021

Abstract
Background
The benefits of chronic polytherapy in reducing readmissions and death after myocardial infarction (MI) have been clearly shown. However, real-world evidence shows poor medication adherence and large geographic variation, suggesting critical issues in access to optimal care. Our objectives were to measure adherence to polytherapy, to compare the amount of variation attributable to hospitals of discharge and to community-based providers, and to identify determinants of adherence to medications.

Methods
This is a population-based study. Data were obtained from the information systems of the Lazio and Tuscany Regions, Italy (9.5 million inhabitants). Patients hospitalized with incident MI in 2010–2014 were analyzed. The outcome measure was medication adherence, defined as a Medication Possession Ratio (MPR) ≥ 0.75 for at least 3 of the following drugs: antiplatelets, β-blockers, ACEI/ARBs, statins. A 2-year cohort-study was performed. Cross-classified multilevel models were applied to analyze geographic variation. The variance components attributable to hospitals of discharge and community-based providers were expressed as Median Odds Ratio (MOR).

Results
A total of 32,962 patients were enrolled. About 63% of patients in the Lazio cohort and 59% of the Tuscan cohort were adherent to chronic polytherapy. Women and patients aged 85 years and over were most at risk of non-adherence. In both regions, adherence was higher for patients discharged from cardiology wards (Lazio: OR = 1.58, p < 0.001, Tuscany: OR = 1.59, p < 0.001) and for patients with a percutaneous coronary intervention during the index admission. Relevant variation between community-based providers was observed, though when the hospital of discharge was included as a cross-classified level, in both Lazio and Tuscany regions the variation attributable to hospitals of discharge was the only significant component (Lazio: MOR = 1.30, p = 0.001; Tuscany: MOR = 1.31, p = 0.001).

Conclusion
Adherence to best practice treatments after MI is not consistent with clinical guidelines, and varies between patient groups as well as within and between regions. The variation attributable to providers is affected by the hospital of discharge, up to two years from the acute episode. This variation is likely to be attributable to hospital discharge processes, and could be reduced through appropriate policy levers.
Myocardial bridging presenting as myocardial ischaemia induced cardiac arrest: a case report
Authors: Ki Young-Jae 
Published: April 2021

Abstract
Background
Myocardial bridging is a congenital anomaly defined as a segment of epicardial coronary arteries running through the myocardium. Various complications related to myocardial bridging have been reported, but at present, cardiac arrest has rarely been reported.

Case presentation
We report one case of a patient who was successfully resuscitated from ventricular fibrillation cardiac arrest and was diagnosed with myocardial bridging accompanied by myocardial ischaemia. A 50-year-old woman who had been resuscitated from cardiac arrest transferred to our institution for evaluation and management of out-of-hospital cardiac arrest. We confirmed the diagnosis of significant myocardial bridging with evident myocardial ischaemia by coronary angiography, resting echocardiography and heart MRI. Vasospasm was thought to be a trigger factor judging from the transient ST elevation on electrocardiography. In addition, the finding of septal buckling was detected for the first time throughout the whole cardiac cycle by resting echocardiography in MB.

Conclusion
We report a rare case of survival after out-of-hospital cardiac arrest that might be caused by significant myocardial bridging-induced myocardial ischaemia, which was objectively confirmed by echocardiography and heart MRI. Although myocardial bridging is often overlooked as an aetiology for sudden cardiac death, this case highlights the importance of expanding the differential diagnosis to myocardial bridging in the work-up for the cause of sudden cardiac death.
Patient experiences with the role of physical activity in inflammatory bowel disease: results from a survey and interviews
Authors: Lamers Carlijn R. , de Roos Nicole M. , Koppelman Lola J. M. , Hopman Maria T. E. , Witteman Ben J. M. 
Published: April 2021

Abstract
Background
Physical activity may affect disease activity in patients with inflammatory bowel disease. We used a survey to investigate this association and performed interviews to get a better understanding of patient experiences, and therefore the nature of this association.

Methods
Patients with Crohn’s disease (CD, n = 176) and ulcerative colitis (UC, n = 162) completed the short Crohn’s Disease Activity (sCDAI) or Patient Simple Clinical Colitis Activity Index (P-SCCAI) and the Short Questionnaire to Assess Health-enhancing physical activity (SQUASH). Associations were investigated by multiple linear regression. Semi-structured interviews (7 CD, 7 UC) were conducted to assess patient experiences with the role of physical activity in their disease.

Results
The majority of survey participants were in remission (70%) and adhered to the Dutch physical activity guidelines (61%). In Crohn’s disease, the total physical activity score was inversely associated with disease activity, even after adjustment for confounders (β = − 0.375; p = 0.013). No association between physical activity and disease activity was found in ulcerative colitis. Of the interviewees, 86% experienced beneficial effects of physical activity, such as improved general fitness, quality of life and self-image. However, during periods of active disease they struggled to find the motivation and perseverance to be physically active due to physical barriers.

Conclusions
Crohn’s disease participants with a higher physical activity level had a lower disease activity. This inverse association was not found in ulcerative colitis. Interviews revealed that IBD patients generally experience beneficial effects from physical activity, although the barriers caused by active disease may put them off to be physically active.
Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome
Authors: Li Yue , Liu Qingju , Kang Chengdong , Cui Weijing , Xu Zichuan , Zhong Fu , Gao Xia 
Published: April 2021

Abstract
Background
This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria.

Methods
ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls.

Results
Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 (P < 0.001). In primary nephrotic syndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r = 0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while there was no correlation with 24 hUTP. Urine ANGPTL8 was positively correlated with high-density lipoprotein cholesterol (r = 0.181, P < 0.05) and was significantly negatively correlated with creatinine (r = − 0.323, P < 0.001), eGFR (r = − 0, P < 0.001) and 24 hUTP (r = − 0.268, P = 0.002). Interestingly, the urine ANGPTL8 concentrations in membranous nephropathy and mesangial proliferative glomerulonephritis pathological types were different.

Conclusions
Serum and urine ANGPTL8 levels in primary nephrotic syndrome patients were correlated with blood lipid levels and proteinuria, respectively, suggesting that ANGPTL8 may play a role in the development of primary nephrotic syndrome hyperlipidemia and proteinuria.