bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of low-intensity intradialytic aerobic exercise using a cycle ergometer on lower extremity muscle strength in end-stage renal disease patients undergoing hemodialysis
Authors: Dewi Dilia Ratna , Andriati  , Narasinta Inggar , Widodo  , Melaniani Soenarnatalina 
Published: January 2025

Background: End Stage Renal Disease (ESRD) patients undergoing hemodialysis (HD) tend to be less active, experience decreased exercise capacity, and have poor physical function when compared to the general population. Decreased lower extremity physical performance in ESRD is associated with an increased risk of death. Intradialytic exercise is the most feasible option and intradialytic exercise programs are mostly aerobic exercise. This study aims to determine the effect of low-intensity intradialytic aerobic exercise using a cycle ergometer on lower extremity muscle strength with a 30 second sit to stand test in patients with ESRD undergoing HD.
Method: This study is a quasi-experimental design with a pre and post-test randomized control group. The research is performed in the Hemodialysis Installation of Dr. Soetomo General Academic Hospital Surabaya from March to June 2021. From the total of 30 ESRD patients undergoing HD randomly assigned to either treatment or control group, 2 subjects dropped out, leaving 28 ESRD patients. The treatment group received light-intensity intradialytic aerobic exercise with a cycle ergometer, performed during the first two hours of HD, twice weekly, for 12 weeks. The 30-second sit-to-stand (30 STS) test was evaluated at baseline and after 12 weeks in both groups. The data were analyzed in the SPSS package program.
Result: There was no significant difference between of 30 STS results for both groups at baseline. There was a significant increase in the mean of 30 STS results before and after the intervention in the treatment group with a large effect.
Conclusion: Low-intensity intradialytic aerobic exercise using a cycle ergometer for 12 weeks in ESRD patients undergoing hemodialysis increases lower extremity muscle strength.
Clinical benefits of platelet rich plasma therapy in thin endometrium: A systematic review and meta-analysis
Authors: Chilmawati Laili , Dewanto Agung , Lutfi Muhammad , Chandra Lukman Ade 
Published: January 2025

Introduction: Endometrium is one of the primary components of embryo to implant. Adequate endometrium is necessary for embryo to implant successfully. Inadequate endometrium increased the probability of unsuccessful embryonic implantation attempt. Platelet rich plasma (PRP) was recently proposed as therapy option for thin endometrium. The study aimed at evaluating the clinical benefits of PRP therapy by examining the impact the PRP therapy on the thickness of endometrium, chemical and clinical pregnancy rates.
Methods: Recovered randomized controlled trial (RCT) was subjected to investigational study. We conducted a thorough search across the Cochrane Central Register of Controlled Trials, PubMed, and Google Scholar until December 31st, 2022, to locate studies on the application of PRP in female frozen-thawed embryo transfer (FET) as a component of assisted reproductive technology (ART). Both the common effect and random effect models were used to extract and to evaluate the data heterogeneity. The risk of bias 2 (RoB2) tool was employed to assess bias potential.
Results: The endometrial thickness outcome was based on four RCTs of 245 participants. There was a significantly high probability that the thickness of the endometrium in the PRP therapy would increase as compared to the group without any intervention (MD=0.84; 95% CI=0.28-1.39). Significantly higher chemical pregnancy rates were found in the PRP therapy (RR=2.73; 95% CI=1.41-5.27). Also, significantly more cases of clinical pregnancy were found in the PRP therapy (RR=3.16; 95% CI=1.82-5.46).
Conclusions: PRP was a beneficial therapy option for thin endometrium in FET and ART. Particularly, the PRP helped to increase the thickness of endometrium, chemical pregnancy rates and clinical pregnancy rates.
Descending necrotizing mediastinitis secondary to an oral phlegmon: a case report
Authors: Lamerkabel Victor , Santoso Kohar Hari 
Published: January 2025

Background: Rare complications of odontogenic infection can lead to a life-threatening and fatal consequence of descending necrotizing mediastinitis The mortality rate is still between 20 and 40 percent despite improvements in surgical care, diagnostic imaging, and antibiotics. This case report presents a case of descending necrotizing mediastinitis as a secondary complication of oral phlegmon.
Case Presentation: A 51-year-old male patient presented with chief complaints of swelling and pain in the lower right jaw. The patient underwent incision drainage and submandibular dissection which obtained 100 cc of pus and necrotic tissue that originated from submandibular and sublingual region. Laboratory examination showed leukocytosis, in addition the X-ray photo and CT-scan supported diagnosis of mediastinitis. The patient was assessed with oral phlegmon post re-incision drainage and descending necrotizing mediastinitis with jugular vein rupture in the area of infection. The patient received intravenous steroids, fluids, analgesia and broad-spectrum empirical antibiotics. The patient's condition has improved afterwards.
Conclusion: Descending necrotizing mediastinitis is rare but has a serious complication of oral phlegmon therefore the principal management surgical drainage, antibiotics, and airway management needs to be performed accordingly.
Diagnostic values analysis of SARS-CoV-2 antibodies using Mindray CL-900i at Dr. Soetomo Hospital Surabaya
Authors: Savitri Binar Larasanti , Aryati  
Published: January 2025

Background: rRT-PCR is one of the definitive diagnostic tests for COVID-19 infection. The antibody (serological) assay is another method used to diagnose COVID-19 infection. This assay is quick and easy to perform, but it needs a high level of sensitivity and specificity. The objective of this research is to analyse the diagnostic values of SARS-CoV-2 IgM and IgG antibodies produced by patients with confirmed COVID-19 infection using the Mindray CL-900i.
Methods: This study design was an analytic observational study using a cross-sectional design with a diagnostic test approach. rRT-PCR-confirmed COVID-19 infection patients' serum samples were collected between day one and day twenty-one following the onset of symptoms. The positive sample population was divided into three groups: days 1-7 of illness, days 8-14 of illness and days 15-21 days of illness. Anti-SARS-CoV-2 IgM and IgG levels in each sample were evaluated using Mindray CL-900i to determine positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity utilising a Mindray CL-900i.
Results: The anti-SARS-CoV-2 IgM serological assays using Mindray CL-900i showed that IgM has 89.09% sensitivity, 88.57% specificity, 92.45% PPV, and 83.78% NPV. The sensitivity of IgM serology examinations was 87.09% in the days 1-7 of the illness group, 100% in the days 8-14 of the illness group, and 85.71% in the days 15-21 of illness group. Meanwhile, the anti-SARS-CoV-2 IgG serological assays using Mindray CL-900i showed that IgG had 88.9% sensitivity, 94.4% specificity, 96% PPV, and 85% NPV. The sensitivity of IgG serology examinations was 80.64% in the days 1-7 of the illness group, 100% in the days 8-14 of the illness group, and 100% in the days 15-21 of the illness group. Antibodies were detected on days 0-7 following the initiation of symptoms; anti-SARS-CoV-2 IgM demonstrated a higher rate of sensitivity compared to anti-SARS-CoV-2 IgG. The sensitivity of anti-SARS-CoV-2 IgG increased and stayed higher than that of anti-SARS-CoV-2 IgM starting on the eighth day after the onset of symptoms. Detectable IgG was found in the group from the first week of illness; this could be the result of a cross-reaction with previous infections with corona viruses other than SARS-CoV2.
Conclusion: Anti-SARS-CoV-2 IgM and IgG serological assays using Mindray CL-900i were found to be sensitive and specific for diagnosing patients with probable COVID-19 infection.
The correlation of Nrf2 levels with improvement of NIHSS scores in acute ischemic stroke patients with glutathione antioxidant supplementation
Authors: Sembiring Beirnes Fernando , Retnaningsih Retnaningsih , Rahmatika Alfi , Tugasworo Dodik 
Published: January 2025

Background: Acute ischemic stroke triggers complex cellular cascades and increases the production of oxidative stress. Nrf2 (nuclear erythroid-related factor 2) is a transcription factor that regulates a series of neuroprotective antioxidant genes that can improve the clinical outcome of stroke. Glutathione is an antioxidant that can protect cells against oxidative stress and can increase Nrf2 levels. This study aimed to determine the effect of glutathione supplementation on Nrf2 levels and its impact on clinical stroke outcomes.
Methods: The research design was a randomized controlled trial, single-blind, and pre-posttest group. About 41 acute ischemic stroke subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely the treatment and control groups. Serum Nrf2 levels were examined using the ELISA method from venous blood and clinical outcomes were assessed using the NIHSS score between days 1 and 14. The treatment group received 500 mg capsule glutathione supplements per 12 hours orally for 14 days. Analysis was carried out using Statistical Product and Service Solutions (SPSS) edition 29.
Results: There was a significant difference in the increase in serum Nrf2 levels between the treatment and control groups (p = 0.005). There was an increase in serum Nrf2 levels in the treatment group compared to the control group. There was no significant correlation between increasing Nrf2 levels and improving NIHSS scores (p = 0.331).
Conclusion: There was no correlation between increasing Nrf2 levels and improving NIHSS scores in acute ischemic stroke patients who received glutathione antioxidant supplements.
Warm stimulation of the vagus auricular nerve (Jacobson nerve) has the effect of reducing pulse frequency, a new method of psychological relaxation?
Authors: Saleh Arman Yurisaldi , Valentina Rizky , Yogi Saputra Dwi Arwandi 
Published: January 2025

Introduction: Research involving warm temperature stimulation of the auricular vagus nerve is still uncommon. This method is considered because using electric current on the auricular vagus nerve can cause discomfort to the subject. Both electric and warm temperature stimulation target type C sensory nerves. Therefore, to stimulate the auricular vagus nerve, we opted for warm temperature stimulation. This study aimed to determine whether warm stimulation of the auricular vagus nerve affects pulse frequency.
Methods: Twenty-six participants who met the inclusion criteria had their pulse frequency measured. After that, they were asked to use an ear warmer that people usually use in four-season countries for 30 minutes, and then each participant's pulse frequency was measured after using the ear warmer.
Result: The results of this study showed that the average pulse rate before using the ear warmer was 100, while the average pulse rate after using ear warmers was 91. There is a decrease in pulse after using ear warmers, with a significant value (p <0.001).
Conclusion: Research suggests that ear warmers, originally designed for non-therapeutic purposes, may have therapeutic potential. Jacobson's nerve stimulation can reduce heart rate frequency, promoting physical and mental relaxation.
Impact of modified yoga compared to conventional therapy on pain characteristics, cardiorespiratory endurance, body flexibility, salivary cortisol levels, and levels of depression, in patients with cervicogenic headache, a randomized clinical trial
Authors: Hasibuan Robiah Khairani , Haris Salim , Octaviana Fitri , Estiasari Riwanti , Sudarsono Nani Cahyani , Widyahening Indah Suci , Kurniasanti Kristiana Siste , Pandelaki Jacub , Rambe Aldy Safruddin 
Published: January 2025

Introduction: Cervicogenic Headache (CGH) is a chronic headache with a significant prevalence. The pain intensity associated with CGH is usually severe, significantly diminishing the quality of life for those affected. Yoga is thought to promote muscle endurance, body flexibility, and muscle elasticity. The author seeks to explore the potential benefits of yoga for individuals suffering from CGH.
Methods: This was a Randomized Control Trial (RCT), conducted at Qadr Hospital, Banten, focusing on patients aged 18-60 years who visited the neurologist with headaches. The inclusion criteria were patients who had chronic headache originating from the neck (CGH) for a minimum of 12 weeks with at least 6 weeks of treatment. The subjects were divided into two groups; the control group, which received medication, and the yoga group, which received medication as well as participated in modified yoga exercises for 12 weeks, 2 times per week with duration of 90 minutes. After 3 months of intervention, the predictors were re-examined.
Result: Out of 53 subjects, 26 were in the control group and 27 were in the yoga group. There were significant differences between the two groups in mean VO2max after the intervention (p = 0.048), mean body flexibility after the intervention (p < 0.001), mean afternoon salivary cortisol after the intervention (p = 0.027), pain characteristics (intensity, frequency, duration (p < 0.001)), and level of depression (p < 0.001).
Conclusion: Modified yoga gives better clinical improvement compared to conventional therapy for CGH patients.
Improvement in body composition after 12-week basic combat training: a longitudinal study among Republic of Indonesia Defense University cadets
Authors: Purnamasari Dwi Monik , Syafiq Ahmad , Dewi Sartika Ratu Ayu , Lubis Leonardo , Setiarini Asih , Sulistyowati Sigit Fathimah , Sudiarti Trini , Saragih Zaini , Laksminingsih Achadi Endang , Besral  
Published: January 2025

Introduction: Body composition is essential for health, as excessive fat can lead to cardiometabolic diseases. Many factors influence body composition, including intense training such as Basic Combat Training (BCT). The nutritional status of Republic of Indonesia Defense University (RIDU) cadets as a reserve component in national defense is important to be monitored because it affects physical performance. This study assessed anthropometry and body composition among RIDU cadets after BCT. Methods: In this longitudinal study involving 111 female and 146 male RIDU cadets aged 16 to 18, body composition was measured before and after 12 weeks of BCT. Differences were analyzed using the Paired T-test.
Result: The result showed that skinfold bicep, tricep, sub-scapula, supra-clavicula, skinfold thickness, and waist circumference in female and male subjects after BCT were significantly lower while weight and body mass index for age were significantly higher than before BCT. In females, skeletal muscle was higher, but BFP was lower than before.
Conclusion: Overall, body composition improved after BCT, with a more beneficial impact among females. This study highlights that the same training regime benefits females more than males regarding body composition improvements. Additional training regimes should be added for males to achieve comparable results.
V-Y advancement flap in fingertip injury: a systematic review
Authors: Grace Claudia  , Yulian Kenny , Hamid Agus Roy Rusly Hariantana 
Published: January 2025

Background: Fingertip injuries are among the most frequent issues requiring surgical treatment. While they have different reasons, workhorse flaps like VY advances are often utilized to resurface fingertip amputations. These flaps don't require neurovascular dissection, and they are dependable and easy to execute but it is associated with several complications. This systematic review is to review the clinical value and feasibility of V-Y flap in treatment for fingertip reconstruction.
Methods: This systematic review followed PRISMA 2020 guidelines. Literature search was conducted across PubMed, Science Direct, and Sage Pub, focusing on studies from 2014 to 2024 assessing V-Y flap in treatment for fingertip reconstruction. The search strategy followed the PICO framework. Studies were screened by two independent reviewers according to predetermined inclusion criteria. Data extraction and bias evaluation were conducted separately by each reviewer.
Result: Literature search resulted in 291 papers. After further screening, 8 studies were included in the final analysis with a total of 129 patients with fingertip injuries. Six studies used the V-Y advancement flap for all fingers with fingertip injuries, while two studies specifically focused on thumb fingertip injuries treated with the V-Y advancement flap. The predominant gender of the patients in these studies were male. The mean 2-point discrimination was one of the objective parameters used in all the included studies, and some studies assessed subjective satisfaction scores.
Conclusion: The value of VY advancement flaps for fingertip reconstruction has been demonstrated. VY advancement flaps are strong flaps that require just one stage of surgery and have produced good neurosensory, functional, and cosmetic results with few problems and morbidities. The treatment is technically straightforward, simpler, and quicker.
Effect of multiple plasma freeze-thaw cycles on non-invasive prenatal testing
Authors: Ulanova P. V. , Antonenko A. N. , Domoratskaya E. A. , Belov R. O. , Zolotopup A. A. , Leonova V. S. , Krinitsina A. A. , Belenikin M. S. 
Published: January 2025

Aim. To assess non-invasive prenatal testing (NIPT) as an informative criterion for quality of blood plasma and cell-free deoxyribonucleic acid (DNA) (cfDNA) in the case of using stabilization tubes at the preanalytical phase, in the example of plasma samples subjected to long-term storage at room temperature (+18о С) and multiple freezethaw cycles.Material and methods. The plasma samples were subjected to 20 freeze-thaw cycles (-80о С/+18о С), 20-day storage at +18о С with an intermediate cfDNA assessment. The quantitative yield was assessed by fluorometry, while the fragmentation and NIPT data — using realtime polymerase chain reaction (PCR) and high-throughput sequencing, respectively.Results. After multiple freeze-thaw cycles and long-term plasma storage at room temperature (+18о С), a decrease in the integrity and the concentration of cfDNA by the 20th thawing cycle, as well as a tendency to an increase in concentration by 20 days of storage were observed. Despite this, the NIPT results of the studied samples showed a high degree of coincidence with the NIPT data of the reference samples.Conclusion. The mere fact of successful NIPT cannot be considered as a reliable and sufficient criterion for assessing the quality of initial plasma and correct preanalytics. This emphasizes the particular importance of monitoring the conditions for transporting and storing plasma and whole blood samples.
Databank of genomic sequences of pathogenic microorganisms and its role in the implementation of epidemiological surveillance
Authors: Semenenko T. A. , Akimkin V. G. , Solomay T. V. 
Published: January 2025

Despite the fact that databanks of genomic sequences have clear information links with biological samples, they are an independent intellectual resource in demand among many researchers. To deposit information obtained in the course of molecular genetic studies in Russia, the Virus Genome Aggregator of Russia (VGARus) databank was created.Aim. To evaluate data on the variability of genetic sequences of the Epstein-Barr virus (EBV), obtained as a result of Russian studies, and the possibility of their integration into the VGARus database forsubsequent use in epidemiological surveillance.Material and methods. A search for publications was carried out in the PubMed, eLibrary, Cyberleninka databases. In total, the study included 32 papers of Russian and external authors that meet the stated aim. Results. The number of studies containing data on the EBV genetic sequences in the Russian Federation is extremely small. The information presented in publications indicates geographical differences in the ratio of two EBV genotypes, the presence of a special LMP1 TatK gene variant in the Tatars of the Volga region, the difference between Russian EBV samples in the gene encoding the gp350 from those from other world regions. At the same time, information on the genomic sequences obtained in the studies was not deposited in the Russian gene bank in any case.Conclusion. Expanding the potential of the Russian VGARus platform by including information on the genomic sequences of all pathogenic microorganisms circulating in the Russian Federation will require largescale work that takes into account technical features, biological and information security requirements.
Student Motivation and Engagement in Blended Learning Environments in Public Schools of Prishtina – Teachers’ and students’ perspectives
Authors: Baliu Era 
Published: January 2025

With the rapid advancements in technology, the need for combined teaching, face-to-face instruction with online components, became a priority to ensure that students could continue their education in both these learning environments. Blended learning has shown positive impacts on student engagement, motivation, and academic performance in various studies.
Therefore, this study focuses on students’ motivation and engagement during blended learning. The research was conducted in three different schools in Prishtina and the data was collected through two sets of questionnaires—one for students and one for teachers. The findings of the study were mixed. While some strategies and tools proved effective in fostering student engagement, the results also highlighted challenges in maintaining motivation and active participation in blended learning classroom. Ultimately, the study offers valuable insights into how online education can be structured to better support student learning and engagement in a blended learning environment, especially in younger learners.
SIFAT-FK RUANG BARISAN CESARO ORLICZ
Authors: Haryadi Haryadi - 
Published: January 2025

The Cesaro sequence space , ( , which is the FK-space, has been generalized to the Cesaro-Orlicz sequence space . This prompted the study of several properties in that have been known in . In this paper, the properties of completeness and FK-properties in the Cesaro-Orlicz space are discussed. For this discussion, a modular approach is used. The results of the study show that the space is a convex modular space. This sequence space is also complete to the Luxemburg norm and has K-properties. Furthermore, this space is a BK-space. These results can be used to study the Kothe-Toeplitz dual, which is an important part of the transformation of the infinite matrix