bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Efficacy of Serum Lipoprotein(A) Combined with TSH in Patients with Acute Coronary Syndrome After Coronary Angiography
Authors: Xu Kaihang , Wang Le , Han Chuyi , Zhang Yingyi , Zhang Rui , Li Wenyu , Li Tingting , Dong Lijie , Hu Yuecheng , Xu Jinghan , Liu Chunwei , Wei Ao , Qi Wei , Jin Dongxia , Zhang Jingxia , Cong Hongliang 
Published: September 2021

Abstract
Backgroud： Elevated lipoprotein(a) [Lp(a)] and thyroid stimulating hormone (TSH) are both associated with coronary artery disease (CAD), but it was controversial in ACS patients. Moreover, patients with elevated plasma TSH tend to have higher levels of lipoprotein. We supposed that patients with elevated LP (a) and TSH may have a adverse prognosis after coronary angiography.Methods: We consecutively recruited 1756 patients who underwent coronary angiography, of which 1473 patients with ACS were eventually enrolled. Major adverse cardiovascular events (MACEs) contained a complex of non-fatal stroke, non-fatal myocardial infarction, ischemic cardiovascular events, and cardiovascular death. According to the occurrence of end events within 27.4 months, the patients were split into two groups: non-endpoint event group (n = 1288) and endpoint event group (n = 185). The date between the two groups were compared. Serum LP (a) was measured by latex agglutination immunoassay (Roche Diagnostics GmbH, Mannheim, Germany).Results: During a median follow-up of 27.4 months, 185 (12.56%) MACEs occurred. Compared with the non-endpoints group，patients in the end-points group had higher level of preoperative LP (a), LDL and TSH (all P<0.05). Multivariate Cox proportional hazard model showed that LP (a) was an independent risk factor for adverse prognosis after coronary angiography in ACS patients, LP (a) > 53.8nmol/L (highest tertile ) predicted 1.704-fold risk for adverse prognosis of ACS (95%CI 1.194~2.433；P＜0.05); Interestingly, patients with elevated LP (a) and TSH concomitantly conferred the highest risk for adverse prognosis OR=3.090 95%CI 1.657~5.765；P＜0.001).Conclusion: LP (a) was an independent risk factor for adverse prognosis after coronary angiography in ACS patients, and the predictive efficacy was enhanced by TSH.
Ketogenic Diet Ameliorates Inflammation by Inhibiting the NLRP3 Inflammasome in Osteoarthritis
Authors: Kong Ganggang , Wang Jinyang , Li Rong , Huang Zhiping , Wang Le 
Published: September 2021

Abstract
Background: The nucleotide oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome has been reported to be involved in the pathological process of osteoarthritis (OA) inflammation. The ketogenic diet (KD), which previously demonstrated to inhibit NLRP3 inflammasome activation, was evaluated to elucidate its protective mechanism against OA in rats. Methods: Anterior cruciate ligament transaction (ACLT) together with partial medial meniscectomy was used to create an OA model of rat knee joint. After treatment with KD or standard diet (SD) for 8 weeks, the knee specimens were obtained for testing. Results: KD significantly increased the content of β-hydroxybutyrate (βOHB) in rats. Compared with the SD group, KD significantly reduced the damage caused by OA in the articular cartilage and subchondral bone. NLRP3 inflammasome and inflammatory cytokines interleukin-1 β (IL-1 β) and IL-18 were significantly increased in the SD group compared with the Sham group, while their expressions were significantly decreased in rats treated with KD. In addition, MMP13 in the KD group was significantly decreased compared with that in the SD group, while COL2 was significantly increased. Conclusions: This study confirmed that KD can protect the articular cartilage and subchondral bone in a rat OA model, and its mechanism is that KD reduces the OA inflammatory response by inhibiting the activation of NLRP3 inflammasome.
Process Optimization at an Industrial Scale in the adsorptive removal of Cd2+ ions using Dolochar via Response Surface Methodology
Authors: Upadhyay Utkarsh , Gupta Sarthak , Agarwal Ankita , Sreed Inkollu , Anitha Kayamkulathethu Latitha 
Published: September 2021

Abstract
Over the years, researchers have continuously searched for ways to achieve adsorption of heavy metal ions from the industrial effluents at lowest possible cost, which has resulted into the development of innumerous special type of low cost adsorbents, called biosorbents. While potential of many biosorbents have been explored in laboratory setup, very few studies have tried to scale up the biosorption process and predict the performance of these biosorbents in a large scale industrial setup. In this work, performance of laboratory synthesized dolochar has been investigated for adsorption of Cd2+ ions in a large scale process with the application of Aspen Adsorption. Moreover, the optimum values of the operating parameters (namely, flow rate, bed height and inlet metal ion concentration) that would result into maximum amount of cadmium ion adsorption (high exhaustion capacity) in minimum time (less exhaustion time) for a fixed mass of dolochar (1200 kg) have been calculated via the application of Response Surface Methodology. It was found out that, at optimum values of bed height (3.48 m), flow rate (76.31 m3/day) and inlet concentration (10 ppm), the optimized value of exhaustion capacity and exhaustion time for cadmium ion adsorption in dolochar packed bed is equal to 1.85 mg/g and 11.39 hours, respectively. The validity of these simulation experiments can be proven by the fact that the obtained exhaustion capacity of dolochar packed beds always remained in close proximity of the experimentally obtained value of adsorption capacity of the dolochar in batch process mode (equal to 2.1 mg/g).
Corpus Analysis of Interactional Response Words as Indicators of Shared Understanding in Medical Problem-Based Learning Tutorials
Authors: Tokode Olukayode Matthew , Dennick Reg 
Published: September 2021

Abstract
Background Shared understanding is essential to effective collaborative learning. Interactive processes occurring in problem-based learning (PBL) tutorials have been explored to determine their cognitive and social advantages, but shared understanding is a relatively under-researched social process of PBL. The objective of this study is to describe how medical students share understanding in medical problem-based learning tutorials. MethodsWe recruited participants from first-year medical students in a single institution’s problem-based learning graduate entry curriculum. Transcripts from full cycles of eight tutorial groups were compiled to form the study corpus. Small interactional response words as indicators of shared understanding were measured using the Wmatrix 3 programme, and concordance lineswere analysed manually to determine word functions. ResultsInteractional response words were most prevalent in session 1 and least prevalent in session 2 of the PBL cycle. Interactional response words were used to mark unexpanded and simple and complex content expansion functions. While affirmation content expansion functions and reactive content expansion functions were more prevalent in sessions 1 and 3, negation content expansion functions were more frequent in session2. The frequency of interactional response words and their functions seem to align with the focus of each PBL tutorial session. ConclusionsDemonstrating the feasibility of corpus linguistics methodology for PBL concept analysis, this study showed that students in PBL tutorials attained sophisticated levels of shared understanding. We discussed the implication of the results for interprofessional teamworking and patient-doctor communication.
Coexisting protruding osteocyte and arachnoid cyst mimicking spinal cord herniation in a patient with Brown Sequard syndrome
Authors: li jinxing , Sasamori Toru , Hida Kazutoshi 
Published: September 2021

Abstract
This 68-year-old man presented with progressive spastic paraparesis of 2-month duration. The diagnosis was Brown-Sequard syndrome(BSS). Magnetic resonance imaging (MRI) revealed ventral displacement of the spinal cord at Th 7–8. The spinal cord deformity was dominant on the left side. He underwent surgery under the preoperative diagnosis of spinal cord herniation at Th 7–8. Intraoperatively we detected an arachnoid cyst and an osteophyte that compressed the spinal cord at Th 7–8 dorsally and ventrally rather than spinal cord herniation. Postoperative MRI showed successful spinal cord decompression. His neurological findings improved remarkably just after surgery. Although the misdiagnosis of spinal hernia in the actual presence of arachnoid cysts has been reported, ours is the first case of both, a lateralized osteophyte and an arachnoid cysts mimicking spinal cord herniation.
Inelastic phonon transport across atomically sharp metal/semiconductor interfaces
Authors: Song Houfu , Liu Fang , Hu Song , Li Qinshu , Yang Susu , Zhao Lu , Jiang Hailing , Wang Jinlin , Wang Tao , Koh Yee Kan , Kang Feiyu , Wu Junqiao , gu xiaokun , Sun Bo , Wang Xinqiang 
Published: September 2021

Abstract
Understanding thermal transport across metal/semiconductor interfaces is crucial for heat dissipation of electronics The dominant heat carriers in non-metals, phonons, transport elastically across most interfaces, except for a few extreme cases where the two materials that formed the interface are highly dissimilar with a large difference in Debye temperature. In this work we show that even for two materials with similar Debye temperatures (Al/Si, Al/GaN), a substantial portion of phonons will transport inelastically across their interfaces at high temperatures, significantly enhancing interface thermal conductance. Moreover, we find that interface roughness strongly affects phonon transport process. For atomically sharp interfaces, phonons are allowed to transport inelastically and interface thermal conductance linearly increases at high temperatures. With increasing interface roughness, inelastic phonon transport rapidly diminishes. Our results provide new insights on phonon transport across interfaces and open up opportunities to engineering interface thermal conductance specifically for materials of relevance to microelectronics.
Sources, Bioavailability And Adequacy of Zinc Intake Among Rural-Resident Men In Malawi
Authors: Pakira Lydia , Kalimbira Alexander 
Published: September 2021

Abstract
Background: Zinc deficiency (ZnD), measured using serum zinc (Zn) prevails in 66% of 20–54 year-old men in Malawi, and is higher than that of other demographic groups. We conducted this study to identify local plant and animal sources of Zn; to determine the frequency of intake of Zn-rich foods; and, to assess the bioavailability of Zn in the food sources.Methods: We employed a descriptive cross-sectional study of 20–54 year-old men (n=101) who are residents of a rural area of Lilongwe district in central Malawi. Dietary assessment was done using a food frequency questionnaire and 24-hour dietary recall. Dietary adequacy was assessed using modified NutriSurvey 2007. Zinc bioavailability was estimated using Murphy’s model of algorithm based on FAO/WHO Zn bioavailability factors.Results: Only 20.3% of the participants were knowledgeable of Zn, and mostly cited rice, cassava, sweet potato, milk and fish as sources of Zn. Degermed-dehulled hard porridge (locally called nsima) (53.5%), small fish (30.7%), mangoes (69.3%), groundnuts (20.8%), pumpkin leaves (65.3%) and sunflower oil (24.8%) were the most frequently consumed foods. Slightly over one third (36.6%) of the participants met the recommended dietary allowance for Zn (mean intake of 14.4±14 mg), but ˂1% consumed Zn that was bioavailable (mean 2.2±2.5 mg).Conclusion: Habitual intake of plant-based diets with poorly bioavailable Zn was widespread among men in this rural population in Malawi, which led to inadequate dietary Zn intake. Food systems-based operational research should be conducted to understand barriers and facilitators of adequate intake of bioavailable Zn in rural areas of Malawi.
Eye-Gaze Control of a Wheelchair Mounted 6DOF Assistive Robot for Activities of Daily Living
Authors: Sunny Md Samiul Haque , Zarif Md Ishrak Islam , Rulik Ivan , Sanjuan Javier , Rahman Mohammad Habibur , Ahamed Sheikh Iqbal , Wang Inga , Schultz Katie , Brahmi Brahim 
Published: September 2021

Abstract
Background: Building control architecture that balances the assistive manipulation systems with the benefits of direct human control is a crucial challenge of human-robot collaboration. It promises to help people with disabilities more efficiently control wheelchair and wheelchair-mounted robot arms to accomplish activities of daily living.Methods: In this paper, our research objective is to design an eye-tracking assistive robot control system capable of providing targeted engagement and motivating individuals with a disability to use the developed method for self-assistance activities of daily living. The graphical user interface is designed and integrated with the developed control architecture to achieve the goal.Results: We evaluated the system by conducting a user study. Ten healthy participants performed five trials of three manipulation tasks using the graphical user interface and the developed control framework. The 100% success rate on task performance demonstrates the effectiveness of our system for individuals with motor impairments to control wheelchair and wheelchair-mounted assistive robotic manipulators.Conclusions: We demonstrated the usability of using this eye-gaze system to control robotic arm mounted on wheelchair in activities of daily living for the people with disabilities. We found high levels of acceptance with higher ratings in evaluation of the system with healthy participants. Trial registration: Not applicable.
Global Famine after Nuclear War
Authors: Xia Lili , Robock Alan , Scherrer Kim , Harrison Cheryl , Jaegermeyr Jonas , Bardeen Charles , Toon Owen , Heneghan Ryan 
Published: September 2021

Abstract
In a nuclear war, bombs targeted on cities and industrial areas would start firestorms, injecting large amounts of soot into the upper atmosphere, which would spread globally and rapidly cool the planet. The soot loadings would cause decadal disruptions in Earth’s climate, which would impact food production systems on land and in the oceans. In 1980s, investigations of nuclear winter impacts on global agricultural production and food availability for 15 nations, but new information now allows us to update those estimates. Recently, several studies analyzed changes of major grain crops and marine wild-catch fisheries for different scenarios of regional nuclear war using sophisticated models. However, the impact on the total food supply available to humans is more complex. Here we show that considering all food sources and potential adaptation measures, such as using animal feed directly for humans, famine would result for most of Earth even from a war between India and Pakistan using less than 3% of the global nuclear arsenal. We look at the climate impacts from a range of scales from regional to global nuclear war, and estimate the total amount of food calories available in each nation, including crops, livestock, and fisheries, for each year following a nuclear holocaust. Our findings quantify the global indirect impacts of nuclear war away from target areas, and demonstrate the need to prevent any scale of nuclear war.
Heterozygous FMN2 Missense Variant Found in A Family Case of Premature Ovarian Insufficiency
Authors: Li Jie , Peng Tianliu , Wang Le , Long Panpan , Quan Ruping , Tan Hangjing , Zeng Minghua , Wu Xue , Yang Junting , Xiao Hongmei , Shi Xiaobo 
Published: September 2021

Abstract
Background

Premature Ovarian Insufficiency plagues 1% of women under 40, while quite a few remain an unknown cause. The development of sequencing has helped find pathogenic genes and reveal the relationship between DNA repair and ovarian reserve. Through the exome sequencing, our study targets screening out the possible POI pathogenic gene and variants in a Chinese family and 20 sporadic POI patients, preliminarily exploring the functional impact and finding out potential linkages between the gene and POI.
Results

The whole exome sequencing suggested a novel FMN2 heterozygous variant c.1949C > T (p.Ser650Leu) carried by all three patients in a Chinese family and another c.1967G > A(p.Arg656His) variant in a sporadic case. Since no FMN2 missense mutation is reported for causing human POI, we preliminarily assessed p.Ser650Leu variant via cross-species alignment and 3D modeling and found it possibly deleterious. A series of functional evidence was consistent with our hypothesis. We proved the expression of FMN2 in different stages of oocytes and observed a statistical difference of chromosomal breakages between the POI patient carrying p.Arg656His variant and the health control (p = 0.0013). Western Blot also suggested a decrease in FMN2 and P21 in the mutant type and an associated increase in H2AX. The p.Arg656His variant with an extremely low frequency also indicated that the gene FMN2 might play an essential role in the genetic etiology of POI. To the best of our knowledge, this is the first POI report on missense variants of FMN2.
Conclusion

This finding indicates a novel gene possibly related to POI and sheds lights on the study of FMN2.
MNB1 gene is involved in regulating the iron-deficiency stress response in Arabidopsis thaliana
Authors: Song Hui , Chen Feng , Wu Xi , Hu Min , Geng Qingliu , Ye Min , Zhang Cheng , Jiang Li , Cao Shuqing 
Published: September 2021

Abstract
Abstract Iron (Fe) is an indispensable mineral element for normal growth of plants. Fe deficiency induces a complex series of responses in plants, involving physiological and developmental changes, to increase Fe uptake from soil. However, the molecular mechanism involved in plant Fe-deficiency is not well understood. Here, we found that the MNB1 gene is involved in modulating Fe-deficiency response in Arabidopsis thaliana . The expression of MNB1 was inhabited by Fe-deficiency stress. Knockout of MNB1 led to enhanced Fe accumulation and tolerance, whereas the MNB1-overexpressing plants were sensitive to Fe-deficiency stress. Lower H 2 O 2 concentrations in mnb1 mutant plants were examined under Fe deficiency circumstances compared to wild-type. On the contray, higher H 2 O 2 concentrations were found in MNB1-overexpressing plants, which was adversely linked with malondialdehyde (MDA) concentrations. Furthermore, in mnb1 mutants, the transcription level of the Fe-uptake and translocation genes, FIT , IRT1 , FRO2 , Z IF , FRD3 , NAS4 , PYE and MYB72 , were considerably elevated during Fe-deficiency stress, resulting in higher Fe accumulation. Together, our findings show that the MNB1 gene negatively controls the Fe-deficiency response in Arabidopsis via modulating reactive oxygen species (ROS) levels and the ROS-mediated signaling pathway, thereby affecting the expression of Fe-uptake and translocation genes.
Effects of HIV Status and History of Pregnancy Termination on Trends of Family Planning Knowledge among Women Living in Nine Fragile Countries
Authors: Woytowich Daniel , Xie Bin 
Published: September 2021

Abstract
Background: To decrease the proportion of women in fragile or conflict-affected situations (FCS) that need, but are not using modern contraception, the global health community must better understand family planning (FP) knowledge gaps; and elucidate which subgroups of women are, and are not, effectively being reached with FP information. This study investigated whether women with notable sexual and reproductive health histories that put them at risk for future pregnancy complications, namely HIV+ women and women with history of terminated pregnancy (HTP), would possess more complete FP knowledge and/or recall being given FP information more readily than HIV- women and women with no HTP (NHTP), respectively. Methods: Knowledge of several contraceptive methods, and the prevalence of women who recalled being given FP information at a healthcare visit, or via TV, radio, or periodical were estimated across HIV, HTP, and country subgroups. HIV+ and HTP status were major predictors in multivariate logistic regressions analyzing the odds of knowing a specified method of contraception or of recalling being given FP information via the modes considered. Results: HIV+ as opposed to HIV- women showed significantly higher odds of knowing about the pill (p=0.001), IUD (p<0.001), injectables (p=0.005), male condoms (p<0.001), female condoms (p<0.001), and implants (p<0.001); but not female or male sterilization. HIV+ women demonstrated higher odds of recalling being given FP information at a health visit (p=0.001), whereas HTP women did not. HTP women showed higher odds (p<0.001) of knowing each modern method of FP with the exception of male sterilization and of recalling TV (p=0.01) and radio (p<0.001) FP messages. Conclusions: Notable findings were the higher FP awareness among HIV+ and HTP women, and the observation that HIV+ women were seemingly provided FP information more readily at healthcare visits than were HTP women, despite their similar risk profiles concerning future pregnancies. Subsequent studies may elucidate why these patterns were observed and indicate which other diagnostic groups are effectively being reached with FP education, and which are not. Understanding trends and predictors of FP knowledge can help practitioners better target FP counseling efforts in FCS toward knowledge gaps and their causes.
Tensor-Based DOA Estimation for Array Virtual Translation
Authors: Peng Jiaqiang , Zheng Guimei 
Published: September 2021

Abstract
In order to make up for the problem that the tensor-based spatial smoothing DOA estimation algorithm cannot make good use of the physical aperture of the array, this paper proposes a tensor-based array virtual translation DOA estimation algorithm. Under the framework of the tensor-based DOA estimation algorithm, the algorithm applies the array virtual translation technique to the factor matrix obtained after tensor decomposition, which can be expanded into signal subspace and approximately has a Vandermonde structure. Furthermore, the available array aperture of the algorithm is expanded, the estimation accuracy is improved, and the limitation of the physical array aperture on the algorithm’s multi-target estimation ability is broken. Since the processing technique proposed in this paper has nothing to do with the construction of tensors, this technique is suitable for all DOA estimation algorithms based on tensors. Theoretical analysis and numerical simulation verify the effectiveness of the algorithm proposed in this paper.
Experimental realization of high-fidelity quantum logic gate between photons
Authors: Shi Shuai , Xu Biao , Zhang Kuan , Ye Gen-Sheng , Xiang De-Sheng , Liu Yubao , Wang Jingzhi , Su Daiqin , Li Lin 
Published: September 2021

Abstract
Quantum logic gates with fidelity above fault-tolerant threshold are building blocks for scalable quantum technologies[1,2]. Compared to other types of qubits, photon is one of a kind due to its unparalleled advantages in long-distance quantum information exchange[3-5]. As a result, high-fidelity photonic quantum operations are not only indispensable for photonic quantum computation[6-8] but also critical for quantum network[2,9]. However, two-qubit photonic quantum logic gate with fidelity comparable to that of leading physical systems, i.e. 99.7% for superconducting circuits[10] and 99.9% for trapped ions[11], has not been achieved. A major limitation is the imperfection of single photons[12]. Here, we overcome this limitation by using high-quality single photons generated from Rydberg atoms as qubits for the interference-based gate protocol, and achieve a gate fidelity up to 99.84(3)%. Our work paves the way for scalable photonic quantum applications[13-15] based on near-optimal single-photon qubits and photon-photon gates.