bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pesquisa em Cuidado Paliativo no Brasil
Authors: Oliveira Livia Costa de 
Published: June 2021

Atualmente, a pesquisa relatada na literatura científica no âmbito do cuidado paliativo no Brasil é demasiadamente limitada. Há um estigma cultural que iguala o cuidado paliativo ao cuidado de fim de vida, associado a imensas lacunas no campo do ensino e pesquisa que precisam ser preenchidas para contrapor a essa questão. Portanto, é necessário que o desenvolvimento científico seja capaz de responder a aspectos conflitantes de cada um desses momentos, não só relacionados ao cuidado de fim de vida, período em que o delineamento dos estudos pode ainda envolver questões de natureza ética complexas. Faz-se necessária a condução de pesquisas metodologicamente rigorosas, capazes de fornecer evidências de alta qualidade, propiciando o embasamento para a construção de protocolos capazes de conduzir a melhoria da prática clínica ao cuidado paliativo, em todas as suas fases, bem como a formulação de políticas de saúde relacionadas à temática.
LEGAL REGULATION ON THE CREATION AND FUNCTIONING OF INNOVATION CLUSTERS IN UKRAINE
Authors: Христина Іваницька  
Published: June 2021

The article reviews the regulatory framework on the basis of which the creation and functioning of innovation clusters as an association of objects of innovative infrastructure of Ukraine.During the research, the author concludes that it is advisable to classify the regulatory regulation of the activity of innovation clusters in Ukraine into two categories: general and special. The general regulatory framework is aimed at creating elements of innovation clusters as legal entities; special aimed at regulating issues of innovation and intellectual property.At the same time, the basic principles of creation and functioning of the legal framework governing the issues of innovation clusters are highlighted: systematicity, accessibility and legality.In the article it is stated that legislative regulation, covering the issues of the functioning of the innovation clusters is incomplete and fragmented, which in turn impedes the full, strategic and cost-effective development of innovation clusters. Hence, the author advices to propose the legislator to regulate the investigated issue at the level of a separate legal act.Besides proper legislative framework, the author pays attention to the necessity of the attraction of budgetary and extra-budgetary funding, including facilitating the participation of clusters in competitions and events conducted by state and regional development institutes, state authorities and local self-government bodies. It is also obvious that there is a need of facilitating the promotion and sale of innovative products of cluster participants in the domestic and world markets; implementation of projects of cluster participants with involvement of state and regional development institutes.At the end of the research the author generates the basic directions of improvement of the policy of legal regulation of the cluster innovation system of Ukraine, proposes concrete measures in the direction of its improvement and modernization.
Evolution of Seismicity During a Stalled Episode of Reawakening at Cayambe Volcano, Ecuador
Authors: Butcher S. , Bell A. F. , Hernandez S. , Ruiz M. 
Published: June 2021

Cayambe Volcano is an ice-capped, 5,790 m high, andesitic-dacitic volcanic complex, located on the equator in the Eastern Cordillera of the Ecuadorian Andes. An eruption at Cayambe would pose considerable hazards to surrounding communities and a nationally significant agricultural industry. Although the only historically documented eruption was in 1785, it remains persistently restless and long-period (LP) seismicity has been consistently observed at the volcano for over 10 years. However, the sparse monitoring network, and complex interactions between the magmatic, hydrothermal, glacial, and tectonic systems, make unrest at Cayambe challenging to interpret. In June 2016 a seismic “crisis” began at Cayambe, as rates of high frequency volcano-tectonic (VT) earthquakes increased to hundreds of events per day, leading to speculation about the possibility of a forthcoming eruption. The crisis began 2 months after the Mw7.8 Pedernales earthquake, which occurred on the coast, 200 km from Cayambe. Here we show that the 2016 seismicity at Cayambe resulted from four distinct source processes. Cross correlation, template matching, and spectral analysis isolate two source regions for VT earthquakes–tectonic events from a regional fault system and more varied VTs from beneath the volcanic cone. The temporal evolution of the LP seismicity, and mean Q value of 9.9, indicate that these events are most likely generated by flow of hydrothermal fluids. These observations are consistent with a model where a new pulse of magma ascent initially stresses regional tectonic faults, and subsequently drives elevated VT seismicity in the edifice. We draw comparisons from models of volcano-tectonic interactions, and speculate that static stress changes from the Pedernales earthquake put Cayambe volcano in an area of dilation, providing a mechanism for magma ascent. Our findings provide a better understanding of “background” seismicity at Cayambe allowing faster characterization of future crises, and a benchmark to measure changes driven by rapid glacial retreat.
IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational
Authors: Curin Mirela , Huang Huey-Jy , Garmatiuk Tetiana , Gutfreund Sandra , Resch-Marat Yvonne , Chen Kuan-Wei , Fauland Kerstin , Keller Walter , Zieglmayer Petra , Zieglmayer René , Lemell Patrick , Horak Friedrich , Hemmer Wolfgang , Focke-Tejkl Margarete , Flicker Sabine , Vrtala Susanne , Valenta Rudolf 
Published: June 2021

BackgroundSeveral studies indicate that Der p 7 is an important and clinically relevant allergen of Dermatophagoides pteronyssinus which should be included in vaccines for treatment of house dust mite (HDM) allergy. Aim of this study was to characterize the IgE epitopes of Der p 7.MethodsRecombinant Der p 7 was expressed and purified, analyzed for fold by circular dichroism and tested for its allergenic activity by basophil activation. Seven overlapping, surface-exposed peptides (P1–P7) with a length of 27 to 37 amino acids, which spanned the Der p 7 sequence, were synthesized and tested for IgE reactivity and allergenic activity by basophil activation assay. Carrier-bound peptides were studied for their ability to induce allergen-specific IgG antibodies in rabbits. Peptide-specific antibodies were used to inhibit allergic patients` IgE binding to Der p 7 by ELISA for mapping of IgE epitopes.ResultsrDer p 7 showed high allergenic activity comparable with Der p 5, Der p 21, and Der p 23. None of the seven tested peptides showed any IgE reactivity or allergenic activity when tested with HDM- allergic patients indicating lack of sequential IgE epitopes on Der p 7. IgE inhibition experiments using anti-peptide specific IgGs and molecular modeling enabled us to identify discontinuous, conformational IgE epitopes of Der p 7.Conclusion and Clinical RelevanceIgE epitopes of Der p 7 belong to the conformational and discontinuous type whereas sequential Der p 7 peptides lack IgE reactivity. It should thus be possible to construct hypoallergenic vaccines for Der p 7 based on carrier-bound allergen peptides.
Clinical Impact of Primary Tumor Location in Metastatic Colorectal Cancer Patients Under Later-Line Regorafenib or Trifluridine/Tipiracil Treatment
Authors: Nakajima Hiromichi , Fukuoka Shota , Masuishi Toshiki , Takashima Atsuo , Kumekawa Yosuke , Kajiwara Takeshi , Yamazaki Kentaro , Negoro Yuji , Komoda Masato , Makiyama Akitaka , Denda Tadamichi , Hatachi Yukimasa , Suto Takeshi , Sugimoto Naotoshi , Enomoto Masanobu , Ishikawa Toshiaki , Kashiwada Tomomi , Ando Koji , Yuki Satoshi , Okuyama Hiroyuki , Kusaba Hitoshi , Sakai Daisuke , Okamoto Koichi , Tamura Takao , Yamashita Kimihiro , Gosho Masahiko , Moriwaki Toshikazu 
Published: June 2021

BackgroundPrimary tumor location (PTL) is an important prognostic and predictive factor in the first-line treatment of metastatic colorectal cancer (mCRC). Although regorafenib (REG) and trifluridine/tipiracil (FTD/TPI) have been introduced recently, the clinical impact of PTL in these treatments is not well understood.Materials and MethodsWe retrospectively evaluated patients with mCRC who were registered in a multicenter observational study (the REGOTAS study). The main inclusion criteria were Eastern Cooperative Oncology Group performance status (ECOG PS) of 0–2, refractory or intolerant to fluoropyrimidines, oxaliplatin, irinotecan, angiogenesis inhibitors, anti-epidermal growth factor receptor therapy (if RAS wild-type), and no prior use of REG and FTD/TPI. The impact of PTL on overall survival (OS) was evaluated using Cox proportional hazard models based on baseline characteristics.ResultsA total of 550 patients (223 patients in the REG group and 327 patients in the FTD/TPI group) were included in this study, with 122 patients with right-sided tumors and 428 patients with left-sided tumors. Although the right-sided patients had significantly shorter OS compared with the left-sided patients by univariate analysis (p = 0.041), a multivariate analysis revealed that PTL was not an independent prognostic factor (hazard ratio, 0.95; p = 0.64). In a subgroup analysis, the OS was comparable between the REG and FTD/TPI groups regardless of PTL (p for interactions = 0.60).ConclusionsIn the present study, PTL is not a prognostic and predictive factor in patients with mCRC under later-line REG or FTD/TPI therapy.
The Effect of Adjunctive Mangosteen Pericarp on Cognition in People With Schizophrenia: Secondary Analysis of a Randomized Controlled Trial
Authors: Marx Wolfgang , Skvarc David R. , Mohebbi Mohammadreza , Walker Adam J. , Meehan Alcy , Turner Alyna , Baker Andrea , Dodd Seetal , Cotton Sue M. , Scott James Graham , Kavanagh Bianca E. , Ashton Melanie M. , Brown Ellie , McGrath John J. , Berk Michael , Dean Olivia May 
Published: June 2021

Background: Cognitive impairment is prevalent and often highly burdensome in people with schizophrenia. The aim of this study was to investigate if mangosteen (Garcinia mangostana Linn.) pericarp extract may be an effective intervention to improve cognitive performance in this population.Methods: This was a secondary analysis of a larger randomized placebo-controlled trial that investigated a 24-weeks intervention of mangosteen pericarp extract supplementation in people diagnosed with schizophrenia. A subset of n = 114 participants with completed cognitive outcomes at follow up were included in this analysis. Using the Cogstate Brief Battery, the following cognitive outcomes were assessed: psychomotor function, attention, visual learning and memory (visual and working). Subgroup analyses investigated whether baseline clinical parameters (baseline cognitive functioning, illness severity and duration, depressive symptoms) moderated the relationship between mangosteen pericarp extract intervention and change in cognitive outcomes.Results: There were no significant between-group changes in any cognitive outcomes assessed. Subgroup analysis based on baseline cognition and clinical characteristics did not reveal any significant between-group difference in change.Conclusions: Mangosteen pericarp extract did not affect cognitive outcomes in people with schizophrenia. Further investigation regarding optimal dosing strategies for mangosteen interventions and the testing of additional cognitive domains may be warranted.Trial Registration:ANZCTR.org.au identifier: ACTRN12616000859482, registered 30 June 3 2016.
Operational Challenges in the Use of Structured Secondary Data for Health Research
Authors: Areco Kelsy N. , Konstantyner Tulio , Bandiera-Paiva Paulo , Balda Rita C. X. , Costa-Nobre Daniela T. , Sanudo Adriana , Kiffer Carlos Roberto V. , Kawakami Mandira D. , Miyoshi Milton H. , Marinonio Ana Sílvia Scavacini , Freitas Rosa M. V. , Morais Liliam C. C. , Teixeira Monica L. P. , Waldvogel Bernadette , Almeida Maria Fernanda B. , Guinsburg Ruth 
Published: June 2021

Background: In Brazil, secondary data for epidemiology are largely available. However, they are insufficiently prepared for use in research, even when it comes to structured data since they were often designed for other purposes. To date, few publications focus on the process of preparing secondary data. The present findings can help in orienting future research projects that are based on secondary data.Objective: Describe the steps in the process of ensuring the adequacy of a secondary data set for a specific use and to identify the challenges of this process.Methods: The present study is qualitative and reports methodological issues about secondary data use. The study material was comprised of 6,059,454 live births and 73,735 infant death records from 2004 to 2013 of children whose mothers resided in the State of São Paulo - Brazil. The challenges and description of the procedures to ensure data adequacy were undertaken in 6 steps: (1) problem understanding, (2) resource planning, (3) data understanding, (4) data preparation, (5) data validation and (6) data distribution. For each step, procedures, and challenges encountered, and the actions to cope with them and partial results were described. To identify the most labor-intensive tasks in this process, the steps were assessed by adding the number of procedures, challenges, and coping actions. The highest values were assumed to indicate the most critical steps.Results: In total, 22 procedures and 23 actions were needed to deal with the 27 challenges encountered along the process of ensuring the adequacy of the study material for the intended use. The final product was an organized database for a historical cohort study suitable for the intended use. Data understanding and data preparation were identified as the most critical steps, accounting for about 70% of the challenges observed for data using.Conclusion: Significant challenges were encountered in the process of ensuring the adequacy of secondary health data for research use, mainly in the data understanding and data preparation steps. The use of the described steps to approach structured secondary data and the knowledge of the potential challenges along the process may contribute to planning health research.
Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience
Authors: Li Zai-Shang , Han Hui , Deng Chuang-Zhong , Li Yong-Hong , Wu Chong , Chen Peng , Liu Zhuo-Wei , Qin Zi-Ke , Zhou Fang-Jian 
Published: June 2021

Background: The aim of this study is to determine the necessary extent of penile lymph node dissection (PLND) in penile cancer patients with inguinal lymph node extracapsular extension (ILN-ENE).Methods: Penile cancer patients who underwent PLND in 15 centers from January 2006 to April 2020 were retrospectively analyzed. PLND was performed in patients with ILN-ENE.Results: Sixty-two patients with ILN-ENE were included in the analysis. A total of 51.6% (32/62) of the patients were confirmed to have pelvic lymph node metastasis (PLNM), and 31.3% (10/32) of patients were confirmed to have multiple PLNMs. Of the patients with metastases, 59.4% (19/32) had bilateral inguinal lymph node metastasis (ILNM). According to the anatomical structure, 71.9% (23/32) of the patients had PLNM in the external iliac region, and 56.2% (18/32) had PLNM in the obturator region. Among those with oligo-PLNM, 65.1% (28/43) of the patients had PLNM in the external iliac region and 38.9% (15/43) had PLNM in the obturator region. A significant overall survival difference was observed between patients with the bilateral ILNM and unilateral ILNM (36-month: 21.2 vs. 53.7%, respectively, P = 0.023). Patients with bilateral ILNM had relatively poor metastasis-free survival compared with unilateral ILNM (36-month: 33.0 vs. 13.9%, respectively, P = 0.051).Conclusions: The external iliac and obturator region were the most commonly affected regions in patients with ILN-ENE, and these regions were the only affected regions in patients with oligo-PLNM. Patients with bilateral ILNM had a high risk of PLNM and worse survival.
Autores e alvos da agressão: um estudo da violência escolar em escolas públicas e particulares de Campo Grande/MS
Authors: Maria de Meneses Branca , Regina dos Santos Pedrossian Dulce , De Aquino Souza Rejane , De Sousa Matos da Costa Rayane , Luiz Ferro Angelo 
Published: June 2021

Este artigo apresenta resultados parciais da pesquisa em andamento Violência escolar: discriminação, bullying e responsabilidade, que tem como pressuposto teórico-metodológico a teoria crítica da sociedade. Os participantes do estudo foram 393 alunos (205 de três escolas públicas municipais e 188 de três particulares) do nono ano do ensino fundamental do município de Campo Grande (MS). O instrumento empregado na coleta de dados foi a Escala de Identificação de Bullying (Escala B). O objetivo consistiu em analisar as indicações dos alunos em relação a aspectos da violência escolar: características dos autores e dos alvos da violência; motivos que levam a ser autor de agressão; e sentimentos dos autores e dos alvos da agressão. Dos resultados quanto às características dos autores: fortes, magros, populares, bons esportistas e com más notas; e dos alvos: fracos, gordos, impopulares, maus esportistas e com boas notas. Os motivos se referem a não ter o que fazer, falta de respeito e não ter limites. Quanto aos sentimentos dos autores: covardia, ódio e como não perdedor; e dos alvos: ódio, desejo de vingança, tristeza, inferioridade e desconsiderado/insignificante. Portanto, o estudo sobre a violência escolar a partir dos autores e alvos da agressão evidenciam as dimensões ideológicas e psicológicas implicadas nas relações sociais e que colocam à mostra a cruel e contraditória realidade frente à violência escolar. Não se pode negligenciar que a repetição compulsiva dos atos de violência acaba por levar alunos e professores a se acomodarem diante de sua existência, a se tornarem indiferentes frente à barbárie.
Religious Theory in the Thinai Grammar
Authors: P Ganeshwari 
Published: June 2021

The Tamil word is basic ally from the grammar of the Tamil word. The grammar system that divides world life into 'Thinai' is a very important system in Tamil. Language changes are taking place in a scientifically functioning society. The cultivation and productivity of the foundation of society have an impact on the superstructure of the society, the art, literature and culture. The religious god thought is in the life classification of the Tamil grammar which is the basis for the creation of words. The tholkappiyam period of the resurrection of the collective life is a symbol of the non-religious protodravidian ism and directly links the doctrine of God to the people. The authors of the well developed landslide society, who wrote to tholkappiyam, have also incorporated the theory of God, based on the various religious and social contexts. The Veera Choliam with buddhist background and Neminatha with Jainism link the god sandals in the higher dina. The nannul also inscribes the sanskrit influence of the deity and the naraka of the sanskrit influence, and the sanskrit influential theory of the proto Dravidian grammar of the grammar, the devar and the narakar a number of religious theories.
Major Approaches to the Dosage of Vitamin D in the Elderly: A Systematic Review
Authors: Cadamuro Moniele Matos , Ribas Filho Durval 
Published: June 2021

Introduction: In the scenario of vitamin D deficiency, this incident is prevalent and with risks to public health in the world, reaching approximately 90% of individuals. Hypovitaminosis D can cause, mainly in the elderly, lower bone mineral density, fractures, muscle weakness, falls, and acute respiratory infection. Objective: To evaluate the main clinical results on vitamin D levels in the elderly, as well as to analyze which daily or weekly dose of vitamin D is most effective in the elderly in reducing the number of falls and fractures. Methods: The present study developed a systematic review, addressing randomized clinical studies, diverse clinical studies, systematic reviews, meta-analysis, and the latest international consensus, following the rules of PRISMA. Results and Conclusion: A total of 152 articles were found involving the dosage and the impact of vitamin D in the elderly. In total, 72 articles were evaluated in full and 30 were included. According to the main literary findings, vitamin D deficiency implies problems with mineralization and bone mineral density, causing fractures and an increase in the number of elderly falls. In this sense, SBEM recommends maintaining vitamin D concentrations above 30 ng/mL. Also, vitamin D deficiency points to the occurrence of neurological diseases such as cognitive decline, risk of Alzheimer's disease, and depression. In the current scenario of the pandemic, vitamin D points as an important modulator of the immune system, and its deficiency promotes the unregulated release of cytokines, leading to complications in patients with COVID-19.
DEVELOPMENT OF A SYSTEM FOR AUTOMATED CONTROL OF THE BRICK FIRING PROCESS IN A RING FURNACE
Authors: Тахгириев А. У. , Хамзаев А. С-С. , Вагапов У. А. 
Published: June 2021

В данной статье приводится описание технологического процесса обжига керамического кирпича в кольцевой печи Гофмана. Проанализирован существующий уровень автоматизации объекта. Приведено обоснование для внедрения автоматизированной системы управления процессом обжига кирпича и вариант структурной схемы системы автоматизированного управления. Также представлены основные характеристики интегрированной среды разработки SIMPLE-SCADA, выбранной для организации операторского уровня автоматизированной системы управления технологическим процессом. Для определения показателей качества системы определены прямые и косвенные оценки качества функционирования системы управления.
This article describes the technological process of firing ceramic bricks in a ring Hoffmann furnace. The existing level of object automation is analyzed. The justification for the introduction of an automated control system for the brick firing process and a variant of the block diagram of the automated control system is given. The main characteristics of the integrated development environment SIMPLE-SCADA, selected for the organization of the operator level of the automated process control system, are also presented. To determine the quality indicators of the system, direct and indirect assessments of the quality of the management system are determined.