bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Parametric Study for Radial Cracking in Cement Under Different Loading Events Based on the Stress Intensity Factor
Authors: Dong Xuelin , Duan Zhiyin , Dou Haoyu , Ma Yinji , Gao Deli 
Published: July 2021

AbstractCement is one of the primary barriers in a wellbore and critical to well integrity. Radial cracking is a pervasive failure mode in cement due to the temperature and pressure variation during drilling, completion, or production. This work presents a comprehensive analysis of radial cracking in cement under various loading events. The proposed model estimates the stress intensity factor and fracture surface displacement as indicators for crack propagation and opening, respectively, through a distributed dislocation technique. Three types of radial cracks, divided by their tips terminating at the casing–cement interface, inside cement, or at the cement–formation interface, are considered. Based on this model, we conduct a parametric study for radial cracking under typical loading events such as steam injection, CO2 injection, and high-pressure and high-temperature (HPHT) drilling. Results indicate that the crack near the casing–cement interface has an increased risk for steam injection and HPHT drilling, while all three types of radial cracks are destructive during CO2 injection. The thermal expansion coefficient of cement is a significant parameter for steam and CO2 injection wells. The fluid pressure and the cement’s thickness are crucial to radial cracking under HPHT conditions. Stiffer cement could promote crack opening for steam injection but prohibit the crack deformation for CO2 injection or HPHT wells. Thicker cement would accelerate radial cracking under the three loading events. These findings are helpful in designing cement to maintain long-term integrity.
Dynamic Analysis of a Novel Quadruple Combined Cycle Based on Integrated Solar Tower-Gas Turbine-Supercritical CO2 and Organic Rankine Cycles
Authors: Abbasi Narges , Khoshgoftar Manesh Mohammad Hasan , Yazdi Mohsen 
Published: July 2021

Abstract
In this article, a novel quadruple cycle for power generation is presented. It consists of a gas turbine cycle, a Brayton cycle of supercritical carbon dioxide, a Rankin organic cycle with a cyclopentane working fluid, a Rankin steam cycle, a central tower, and a heliostat solar field. Because of improving the Brayton cycle's performance, supercritical carbon dioxide and the Rankine organic cycle have been added to the system. A solar tower system has been used to heat the incoming airflow to the combustion chamber. The heat generated by the solar tower in the first part increases the gas turbine cycle's air temperature, and in the second part, the water vapor heats the Rankin steam cycle. Due to solar radiation instability, the proposed system's performance is dynamically examined every hour of the year, and the results are reported. The thermodynamic simulation results are validated by thermoflex software and reference case with high accuracy. In this regard, energy, exergy, exergoeconomic, exergoenvironmental, emergoeconomic, and emergoenvironmental (6E) analyses have been performed for this system. The result indicates that the gas turbine cycle's fuel consumption is reduced by about 9% to 1.53 kg/s with the solar system's addition. Using solar energy and the Rankin steam cycle, the cycle's production capacity will increase from 43 MW to 66 MW.
Evaluating the Market Potential of Concentrated Solar Thermal Technology for Different Applications in the MENA Region
Authors: Elmorsy Louay , Hamdy Sarah , Morosuk Tatiana , Tsatsaronis George 
Published: July 2021

Abstract
Missing financial and regulatory frameworks lead to low development and stagnating costs of concentrated solar thermal technology. Nevertheless, in locations with high direct normal irradiance (DNI) such as the Middle East and Northern Africa (MENA) region, the technology could become competitive, being promised a learning rate of 10–20%, and boost local economies. This study aims to identify potential business cases and evaluate the increased technology's investment likelihood in the region, focusing on Egypt. A thorough market assessment on the structure, regulatory framework, demand, and potential revenues was conducted for the power and process heating sector. A SWOT analysis was performed considering the local context and competing technologies. Egypt was shown to offer local manufacturing potential, regulatory framework, and renewable energy (RE) strategies, facilitating the technology's deployment. Moreover, the market is already open for private investment and selected international funds are directed toward CSP development. High initial technology cost, subsidized fuel and electricity prices for industry, alongside lack of long-term financial incentives and awareness of potential long-term benefits for the economy were identified as the most significant threats. High solar heat demand for industrial processes and large potential for concentrated solar heat (CSH) application were identified. Yet, the market is decentralized and the processes are very diverse, moreover retrofitting may pose risks alongside the high upfront investment and additional land costs, which makes concentrated solar heat applications less attractive for the Egyptian industrial sector. Hence, for concentrated solar technology deployment, financial incentives and a regulatory framework specifically directed toward the technology would be necessary.
Azole-Resistant Aspergillus fumigatus Clinical Isolate Screening in Azole-Containing Agar Plates (EUCAST E.Def 10.1): Low Impact of Plastic Trays Used and Poor Performance in Cryptic Species
Authors: Serrano-Lobo Julia , Gómez Ana , Rodríguez-Sánchez Belén , Muñoz Patricia , Escribano Pilar , Guinea Jesús 
Published: July 2021

Azole-containing agar is used in routine
Aspergillus fumigatus
azole resistance screening. We evaluated the impact of the type of plastic used to prepare in-house agar plates on the procedure’s performance against
A. fumigatus sensu stricto
and cryptic species.
A. fumigatus sensu stricto
(
n
= 91) and cryptic species (
n
= 52) were classified as susceptible or resistant (EUCAST E.Def 9.3.2; clinical breakpoints v10).
Early Neoproterozoic (870–820 Ma) amalgamation of the Tarim craton (northwestern China) and the final assembly of Rodinia
Authors: Zhao Pan , He Jinyou , Deng Chenglong , Chen Yan , Mitchell Ross N. 
Published: July 2021

Abstract
In the paleogeographic configuration of the Neoproterozoic supercontinent of Rodinia, the Tarim craton (northwestern China), traditionally seen as a single block, is placed either on the periphery near northern Australia or India or in a central position between Australia and Laurentia. To distinguish between these possibilities, we present here new primary paleomagnetic results from ca. 900 Ma volcanics in the Aksu region of the northwestern Tarim craton. The data reveal a ~28° latitudinal difference between the North Tarim and South Tarim blocks at ca. 900 Ma and constrain the age of amalgamation of the Tarim craton to between 870 and 820 Ma. Combining paleomagnetic poles from Tarim and major cratons of Rodinia with geological evidence, a two-stage orogenic model is proposed for the assembly of Rodinia. Late Mesoproterozoic orogenesis (1.3–1.0 Ga) led to the assembly of Australia–East Antarctica, Baltica, Umkondia, South Tarim, and Cathaysia with Laurentia, forming the core of Rodinia. Thereafter, the Jiangnan–Central Tarim Ocean separating North Tarim and Yangtze from South Tarim and Cathaysia was closed before ca. 820 Ma. This second Jiangnan–Central Tarim orogeny caused nearly coeval amalgamation of the peripheral Tarim and South China cratons by the welding of North Tarim and Yangtze to South Tarim and Cathaysia, respectively. The supercontinent of Rodinia was thus assembled by two orogenic phases separated by ~200 m.y.
Anoxic depositional overprinting of 238U/235U in calcite: When do carbonates tell black shale tales?
Authors: Chen Xinming , Romaniello Stephen J. , McCormick Michael , Sherry Alyssa , Havig Jeff R. , Zheng Wang , Anbar Ariel D. 
Published: July 2021

Abstract
The fidelity of uranium isotopes (δ238U) in marine carbonates as a paleoredox proxy relies on whether carbonates can record and preserve seawater δ238U. Although modern carbonate sediments deposited under oxic conditions have been shown to track seawater δ238U, it remains unknown whether this is true for carbonates deposited under anoxic conditions. This is a crucial question because many ancient carbonates were likely deposited or reworked under anoxic bottom waters. To better understand the behavior of uranium isotopes under this scenario, we investigated U isotope geochemistry in the meromictic Fayetteville Green Lake (FGL; New York, USA), where primary calcite is precipitated from oxic surface waters, sinks past the chemocline, and is deposited under anoxic bottom waters. We observed significant depletions of dissolved U concentration (from 2.7 to 0.9 ppb) and δ238U (from –0.55‰ to –0.96‰) below the chemocline in FGL. Parallel with these depletions, δ238U of sediment traps increased progressively from –0.51‰ to –0.16‰, suggesting that U(VI) reduction was occurring in the anoxic water column. Carbonate sediments deposited under anoxic bottom waters were enriched in U by 6–18× compared to primary calcite. Our data suggest that such significant authigenic U enrichments resulted from U(VI) reduction in the anoxic water column and below the sediment-water interface. The δ238U value in the top 0.25 cm of sediments was –0.29‰ ± 0.10‰, overprinting original δ238U in primary calcite (–0.51‰ ± 0.02‰). Future applications of carbonate δ238U as a paleoredox proxy should consider depositional environments (oxic vs. anoxic) of carbonates.
Construction of the Lesser Himalayan–Subhimalayan thrust belt: The primary driver of thickening, exhumation, and high elevations in the Himalayan orogen since the middle Miocene
Authors: Long Sean P. , Robinson Delores M. 
Published: July 2021

Abstract
Documenting the structural evolution of the Himalayan orogen is fundamental for understanding the dynamics of collisional orogenesis. We argue that the importance of deformation in the frontal, Lesser Himalayan–Subhimalayan (LH-SH) portion of the Himalayan thrust belt for driving crustal thickening over the past ~15–13 m.y. has long been overlooked. To quantify its contribution to thickening, we measured parameters from 22 published cross sections that span the length of the orogen. The mean structural uplift accomplished by the LH-SH thrust belt increases from 10–15 km in the eastern half of the orogen to 15–23 km in the western half. An antiformal culmination constructed by LH duplexing is observed across the orogen and increases in structural height (to as much as 15–20 km) and north-south width moving westward. Construction of the culmination was the primary mechanism for building and maintaining wedge taper. The westward scaling of culmination size is accompanied by doubling and tripling of LH-SH shortening and accretion magnitude, respectively; when combined with a consistent orogen-wide modern taper angle (11° ± 2°), this indicates that duplexing facilitated the growth of an overall larger orogenic wedge moving westward. Following the initial southward propagation of deformation into LH rocks at ca. 15–13 Ma, the Himalayan orogenic wedge has been characterized by stacking of multiple thin, small-displacement thrust sheets to develop a high-taper orogenic wedge. Thus, LH-SH deformation has had a profound effect on driving thickening, exhumation, and the attainment of high elevations since the middle Miocene.
Earth's new tectonic regime at the dawn of the Paleoproterozoic: Hf isotope evidence for efficient crustal growth and reworking in the São Francisco craton, Brazil
Authors: Bruno Henrique , Heilbron Monica , Strachan Rob , Fowler Mike , de Morisson Valeriano Claudio , Bersan Samuel , Moreira Hugo , Cutts Kathryn , Dunlop Joseph , Almeida Rasec , Almeida Julio , Storey Craig 
Published: July 2021

Abstract
A zircon Hf isotope data set from Archean and Paleoproterozoic magmatic and metasedimentary rocks of the southern São Francisco craton (Brazil) is interpreted as evidence of accretionary and collisional plate tectonics since at least the Archean-Proterozoic boundary. During the Phanerozoic, accretionary and collisional orogenies are considered the end members of different plate tectonic settings, both involving preexisting stable continental lithosphere and consumption of oceanic crust. However, mechanisms for the formation of continental crust during the Archean and Paleoproterozoic are still debated, with the addition of magmatic rocks to the crust being explained by different geodynamic models. Hf isotopes can be used to quantify the proportion of magmatic addition into the crust: positive εHf values are usually interpreted as indications of magmatic input from the mantle, whereas crust-derived rocks show more negative εHf. We show that the crust of the amalgamated Paleoproterozoic tectonostratigraphic terranes that make up the southern São Francisco craton were generated from different proportions of mantle and crustal isotopic reservoirs. Plate tectonic processes are implied by a consistent sequence of events involving (1) the generation of juvenile subduction-related magmatic arc rocks, followed by (2) collisional orogenesis and remelting of older crust, and (3) post-collisional bimodal magmatism.
Contamination of the Bushveld Complex (South Africa) magmas by basinal brines: Stable isotopes in phlogopite from the UG2 chromitite
Authors: Zhou Haoyang , Trumbull Robert B. , Veksler Ilya V. , Bindeman Ilya N. , Glodny Johannes , Kaufmann Felix E.D. , Rammlmair Dieter 
Published: July 2021

Abstract
There is abundant evidence for significant H2O in evolved melts from the platinum-rich UG2 chromitite and the Merensky Reef of the Bushveld Complex (South Africa), but there is no consensus about the source of H2O. We report triple-oxygen and hydrogen isotope ratios of interstitial, late-magmatic phlogopite from three localities of the UG2 layer. The phlogopite yielded δD values of −43 to −23, which is &gt;30 higher than previously known from Bushveld rocks and far above the mantle values of ~−75. The phlogopite triple-oxygen isotope ratios are the first to be reported for Bushveld rocks, with values of Δ′17O0.5305 (17O excess relative to the reference line 0.5305) from –0.069 to –0.044 (δ18O 5.2–6.2). The oxygen data support existing models of as much as 30%–40% contamination of mantle-derived magmas in the lower to middle crust. However, the high δD values require a second step of contamination, which we attribute to brines from the marine sediments in the Transvaal Basin at the emplacement level.
First-in-Human Study of the Biodistribution and Pharmacokinetics of 89Zr-CX-072, a Novel Immunopet Tracer Based on an Anti–PD-L1 Probody
Authors: Kist de Ruijter Laura , Hooiveld-Noeken Jahlisa S. , Giesen Danique , Lub-de Hooge Marjolijn N. , Kok Iris C. , Brouwers Adrienne H. , Elias Sjoerd G. , Nguyen Margaret T.L. , Lu Hong , Gietema Jourik A. , Jalving Mathilde , de Groot Derk J.A. , Vasiljeva Olga , de Vries Elisabeth G.E. 
Published: July 2021

Abstract

Purpose:
CX-072, a PD-L1–targeting Probody therapeutic, is engineered to be activated by tumor proteases that remove a masking peptide. To study effects on biodistribution and pharmacokinetics, we performed 89Zr-CX-072 positron emission tomography (PET) imaging.

Experimental Design:
Patients received ∼1 mg, 37 MBq 89Zr-CX-072 plus 0, 4, or 9 mg unlabeled CX-072 and PET scans at days 2, 4, and 7. After that, treatment comprised 10 mg/kg CX-072 q2 weeks (n = 7) + 3 mg/kg ipilimumab q3w 4× (n = 1). Normal organ tracer uptake was expressed as standardized uptake value (SUV)mean and tumor uptake as SUVmax. PD-L1 expression was measured immunohistochemically in archival tumor tissue.

Results:
Three of the eight patients included received 10-mg protein dose resulting in a blood pool mean SUVmean ± SD of 4.27 ± 0.45 on day 4, indicating sufficient available tracer. Tumor uptake was highest at day 7, with a geometric mean SUVmax 5.89 (n = 113) and present in all patients. The median follow-up was 12 weeks (4–76+). One patient experienced stable disease and two patients a partial response. PD-L1 tumor expression was 90% in one patient and ≤1% in the other patients. Mean SUVmean ± SD day 4 at 10 mg in the spleen was 8.56 ± 1.04, bone marrow 2.21 ± 0.46, and liver 4.97 ± 0.97. Four patients out of seven showed uptake in normal lymph nodes and Waldeyer's ring. The tracer was intact in the serum or plasma.

Conclusions:
89Zr-CX-072 showed tumor uptake, even in lesions with ≤1% PD-L1 expression, and modest uptake in normal lymphoid organs, with no unexpected uptake in other healthy tissues.
Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer
Authors: Mirzapoiazova Tamara , Xiao Gang , Mambetsariev Bolot , Nasser Mohd W. , Miaou Emily , Singhal Sharad S. , Srivastava Saumya , Mambetsariev Isa , Nelson Michael S. , Nam Arin , Behal Amita , Atri Pranita , Muschen Markus , Tissot François L.H. , Miser James , Kovach John S. , Sattler Martin , Batra Surinder K. , Kulkarni Prakash , Salgia Ravi 
Published: July 2021

Abstract
Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many cancers, including small cell lung cancer (SCLC). Here we report that LB100, a small molecule inhibitor of PP2A, when combined with platinum-based chemotherapy, synergistically elicited an antitumor response both in vitro and in vivo with no apparent toxicity. Using inductively coupled plasma mass spectrometry, we determined quantitatively that sensitization via LB100 was mediated by increased uptake of carboplatin in SCLC cells. Treatment with LB100 alone or in combination resulted in inhibition of cell viability in two-dimensional culture and three-dimensional spheroid models of SCLC, reduced glucose uptake, and attenuated mitochondrial and glycolytic ATP production. Combining LB100 with atezolizumab increased the capacity of T cells to infiltrate and kill tumor spheroids, and combining LB100 with carboplatin caused hyperphosphorylation of the DNA repair marker γH2AX and enhanced apoptosis while attenuating MET signaling and invasion through an endothelial cell monolayer. Taken together, these data highlight the translational potential of inhibiting PP2A with LB100 in combination with platinum-based chemotherapy and immunotherapy in SCLC.
Preventive Anti-inflammatory Diet to Reduce Gastrointestinal Inflammation in Familial Adenomatous Polyposis Patients: A Prospective Pilot Study
Authors: Belfiore Antonino , Ciniselli Chiara Maura , Signoroni Stefano , Gariboldi Manuela , Mancini Andrea , Rivoltini Licia , Morelli Daniele , Masci Enzo , Bruno Eleonora , Macciotta Alessandra , Ricci Maria Teresa , Daveri Elena , Cattaneo Laura , Gargano Giuliana , Apolone Giovanni , Milione Massimo , Verderio Paolo , Pasanisi Patrizia , Vitellaro Marco 
Published: July 2021

Abstract

Familial adenomatous polyposis (FAP) is an autosomal-dominant hereditary condition associated with germline mutations in the adenomatous polyposis coli gene. Patient management involves prophylactic surgery and intensive life-long endoscopic surveillance. Diet is a major concern for patients with FAP, who are generally free of symptoms before surgery but tend to have issues related to bowel function postoperatively. We hypothesized that a low-inflammatory diet based on the principles and recipes of the Mediterranean diet would reduce markers of local and systemic inflammation. Twenty-eight patients with FAP over 18 years of age who underwent rectum-sparing prophylactic colectomy and were included in our surveillance program participated in a pilot dietary intervention study. Blood and stool samples at baseline (T0), at the end of the dietary intervention (T1, three months), and at the end of the study (T2, six months after T0) were collected. Gastrointestinal inflammation markers including fecal calprotectin, cyclooxygenase-2, and 15-hydroxyprostaglandin dehydrogenase were evaluated. Serum calprotectin, insulin, insulin-like growth factor-1, C-reactive protein, and glycated hemoglobin were also assessed. Significant changes in serum calprotectin, insulin, and insulin-like growth factor-1 levels occurred over time. Borderline significant changes were observed in the neutrophil–lymphocyte ratio. These changes were noticeable immediately at the end of the 3-month active dietary intervention (T1). A significant increase in 15-hydroxyprostaglandin dehydrogenase expression in the normal crypts of matched samples was also observed between T0 and T2. This pilot study supports the hypothesis that a low-inflammatory diet can modulate gastrointestinal markers of inflammation in individuals with FAP.

Prevention Relevance:
Cancer is known to be related to inflammatory conditions. This study suggests that anti-inflammatory dietary intervention may potentially prevent adenomas and cancer in FAP patients by reducing systemic and tissue inflammatory indices.
Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals
Authors: Patel Aniruddh P. , Wang Minxian , Kartoun Uri , Ng Kenney , Khera Amit V. 
Published: July 2021

Background:
Individuals of South Asian ancestry represent 23% of the global population, corresponding to 1.8 billion people, and have substantially higher risk of atherosclerotic cardiovascular disease compared with most other ethnicities. US practice guidelines now recognize South Asian ancestry as an important risk-enhancing factor. The magnitude of enhanced risk within the context of contemporary clinical care, the extent to which it is captured by existing risk estimators, and its potential mechanisms warrant additional study.

Methods:
Within the UK Biobank prospective cohort study, 8124 middle-aged participants of South Asian ancestry and 449 349 participants of European ancestry who were free of atherosclerotic cardiovascular disease at the time of enrollment were examined. The relationship of ancestry to risk of incident atherosclerotic cardiovascular disease—defined as myocardial infarction, coronary revascularization, or ischemic stroke—was assessed with Cox proportional hazards regression, along with examination of a broad range of clinical, anthropometric, and lifestyle mediators.

Results:

The mean age at study enrollment was 57 years, and 202 405 (44%) were male. Over a median follow-up of 11 years, 554 of 8124 (6.8%) individuals of South Asian ancestry experienced an atherosclerotic cardiovascular disease event compared with 19 756 of 449 349 (4.4%) individuals of European ancestry, corresponding to an adjusted hazard ratio of 2.03 (95% CI, 1.86–2.22;
P
<0.001). This higher relative risk was largely consistent across a range of age, sex, and clinical subgroups. Despite the >2-fold higher observed risk, the predicted 10-year risk of cardiovascular disease according to the American Heart Association/American College of Cardiology Pooled Cohort equations and QRISK3 equations was nearly identical for individuals of South Asian and European ancestry. Adjustment for a broad range of clinical, anthropometric, and lifestyle risk factors led to only modest attenuation of the observed hazard ratio to 1.45 (95% CI, 1.28–1.65,
P
<0.001). Assessment of variance explained by 18 candidate risk factors suggested greater importance of hypertension, diabetes, and central adiposity in South Asian individuals.

Conclusions:
Within a large prospective study, South Asian individuals had substantially higher risk of atherosclerotic cardiovascular disease compared with individuals of European ancestry, and this risk was not captured by the Pooled Cohort Equations.