bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Coronary Sinus-Based Mitral Valve Repair Differentially Modulates Coronary Sinus to Mitral Valve Annulus Geometry and Topography
Authors: Rottländer Dennis , Saal Martin , Gödde Miriel , Ögütcü Alev , Degen Hubertus , Haude Michael 
Published: July 2021

Objectives: Coronary sinus (CS) based mitral annuloplasty using the Carillon device is a therapeutic option for the treatment of functional mitral valve regurgitation (FMR).Background: Little is known about the change of CS and mitral valve annulus (MVA) planes following Carillon implantation and how they are modulated by the tension applied on the device.Methods: In a retrospective single-center analysis, 10 patients underwent Carillon device implantation and received CT-angiography (CTA) prior and post CS based percutaneous mitral valve repair. Patients were assigned to responders or non-responders according to the 3-month transthoracic echocardiographic follow-up. A prototype software was used to assess distance and angulation of both CS (pre) or Carillon-device (post) and mitral annulus planes.Results: Comparison of the distance and angulation of the CS plane or Carillon device plane and the MVA plane prior and post intervention showed significant reduction of distance and unchanged angulation in responders while angulation was increased and distance reduced in non-responders without statistical significance. Furthermore, in FMR responders MVA perimeter, anterior-posterior diameter, intercommisural diameter and MVA area were decreased following successful indirect mitral valve annuloplasty, while in FMR non-responders Carillon device implantation had no effect on MVA geometry.Conclusions: Insufficient reduction of FMR following indirect mitral valve annuloplasty is associated with device malposition in relation to the mitral valve annulus. Patient selection using CTA-derived distance and angulation of CS to MVA planes is one option to increase effectiveness of indirect mitral valve annuloplasty.
Real-Time Characterization of Finite Rupture and Its Implication for Earthquake Early Warning: Application of FinDer to Existing and Planned Stations in Southwest China
Authors: Li Jiawei , Böse Maren , Feng Yu , Yang Chen 
Published: July 2021

Earthquake early warning (EEW) not only improves resilience against the risk of earthquake disasters, but also provides new insights into seismological processes. TheFinite-Fault RuptureDetector(FinDer) is an efficient algorithm to retrieve line-source models of an ongoing earthquake from seismic real-time data. In this study, we test the performance of FinDer in the Sichuan-Yunnan region (98.5oE–106.0oE, 22.0oN–34.0oN) of China for two datasets: the first consists of seismic broadband and strong-motion records of 58 earthquakes with 5.0 ≤MS≤ 8.0; the second comprises additional waveform simulations at sites where new stations will be deployed in the near future. We utilize observed waveforms to optimize the simulation approach to generate ground-motion time series. For both datasets the resulting FinDer line-source models agree well with the reported epicenters, focal mechanisms, and finite-source models, while they are computed faster compared to what traditional methods can achieve. Based on these outputs, we determine a theoretical relation that can predict for which magnitudes and station densities FinDer is expected to trigger, assuming that at least three neighboring stations must have recorded accelerations of 4.6 cm/s2or more. We find that FinDer likely triggers and sends out a report, if the average distance between the epicenter and the three closest stations,Depi, is equal or smaller than log10(Ma+b) + c, wherea= 1.91,b= 5.93, andc= 2.34 forM = MW≥ 4.8, andc= 2.49 forM = MS≥ 5.0, respectively. If the data used in this study had been available in real-time, 40–70% of sites experiencing seismic intensities of V-VIII (on both Chinese and MMI scales) and 20% experiencing IX-X could have been issued a warning 5–10 s before theS-wave arrives. Our offline tests provide a useful reference for the planned installation of FinDer in the nationwide EEW system of Chinese mainland.
Exploration of the Shared Gene Signatures and Molecular Mechanisms Between Systemic Lupus Erythematosus and Pulmonary Arterial Hypertension: Evidence From Transcriptome Data
Authors: Yao Menghui , Zhang Chunyi , Gao Congcong , Wang Qianqian , Dai Mengmeng , Yue Runzhi , Sun Wenbo , Liang Wenfang , Zheng Zhaohui 
Published: July 2021

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems. Pulmonary arterial hypertension (PAH) has a close linkage with SLE. However, the inter-relational mechanisms between them are still unclear. This article aimed to explore the shared gene signatures and potential molecular mechanisms in SLE and PAH.MethodsThe microarray data of SLE and PAH in the Gene Expression Omnibus (GEO) database were downloaded. The Weighted Gene Co-Expression Network Analysis (WGCNA) was used to identify the co-expression modules related to SLE and PAH. The shared genes existing in the SLE and PAH were performed an enrichment analysis by ClueGO software, and their unique genes were also performed with biological processes analyses using the DAVID website. The results were validated in another cohort by differential gene analysis. Moreover, the common microRNAs (miRNAs) in SLE and PAH were obtained from the Human microRNA Disease Database (HMDD) and the target genes of whom were predicted through the miRTarbase. Finally, we constructed the common miRNAs–mRNAs network with the overlapped genes in target and shared genes. ResultsUsing WGCNA, four modules and one module were identified as the significant modules with SLE and PAH, respectively. A ClueGO enrichment analysis of shared genes reported that highly activated type I IFN response was a common feature in the pathophysiology of SLE and PAH. The results of differential analysis in another cohort were extremely similar to them. We also proposed a disease road model for the possible mechanism of PAH secondary to SLE according to the shared and unique gene signatures in SLE and PAH. The miRNA–mRNA network showed that hsa-miR-146a might regulate the shared IFN-induced genes, which might play an important role in PAH secondary to SLE.ConclusionOur work firstly revealed the high IFN response in SLE patients might be a crucial susceptible factor for PAH and identified novel gene candidates that could be used as biomarkers or potential therapeutic targets.
Adaptation of the Compensatory Stepping Response Following Predictable and Unpredictable Perturbation Training
Authors: Hasegawa Naoya , Tanaka Shintaro , Mani Hiroki , Inoue Takahiro , Wang Yun , Watanabe Kazuhiko , Asaka Tadayoshi 
Published: July 2021

BackgroundEffective training of the backward step response could be beneficial to improve postural stability and prevent falls. Unpredicted perturbation-based balance training (PBT), widely known as compensatory-step training, may enhance the fear of falling and the patterns of postural muscle co-contraction. Contrastingly, PBT with predictable direction or both direction and timing would suppress the fear and the co-contraction patterns during training, but the efficacy of predictable PBT for unpredictable perturbations is still unknown.ObjectiveTo compare the adaptation effects of compensatory-step training with and without predictable perturbations on backward stepping against unpredictable perturbations.MethodsThirty-three healthy young adults were randomly assigned to one of the following step training groups: Unpredicted, Predicted, and Self-initiated. In training sessions, participants were perturbed to induce a compensatory step with (Predicted group) or without (Unpredicted group) knowledge of the perturbation’s direction or while knowing both the direction and timing of the perturbation (Self-initiated group). In test sessions (pre- and post-training), participants were instructed to recover their postural stability in response to an unpredicted perturbation. The margin of stability (MOS), center of mass (COM) shift, and step characteristics were measured during a backward step in both test and training sessions.ResultsAll three groups showed a significant increase in the step length and velocity in the post-training sessions compared to those in the pre-training sessions. Moreover, in the Unpredicted and Predicted groups, but not in the Self-initiated group, the MOS at step contact was significantly increased following the training session. In addition, the Self-initiated group showed a significant increase in COM shift at 50 ms after slip onset during training compared to the Unpredicted and Predicted groups.ConclusionUnpredicted and predicted PBT improve step characteristics during backward stepping against unpredictable perturbations. Moreover, the unpredictable PBT and PBT with direction-predictable perturbations enhance the feedback postural control reflected as the postural stability at step contact.
The Relative Weight of Temporal Envelope Cues in Different Frequency Regions for Mandarin Disyllabic Word Recognition
Authors: Zheng Zhong , Li Keyi , Guo Yang , Wang Xinrong , Xiao Lili , Liu Chengqi , He Shouhuan , Feng Gang , Feng Yanmei 
Published: July 2021

ObjectivesAcoustic temporal envelope (E) cues containing speech information are distributed across all frequency spectra. To provide a theoretical basis for the signal coding of hearing devices, we examined the relative weight of E cues in different frequency regions for Mandarin disyllabic word recognition in quiet.DesignE cues were extracted from 30 continuous frequency bands within the range of 80 to 7,562 Hz using Hilbert decomposition and assigned to five frequency regions from low to high. Disyllabic word recognition of 20 normal-hearing participants were obtained using the E cues available in two, three, or four frequency regions. The relative weights of the five frequency regions were calculated using least-squares approach.ResultsParticipants correctly identified 3.13–38.13%, 27.50–83.13%, or 75.00–93.13% of words when presented with two, three, or four frequency regions, respectively. Increasing the number of frequency region combinations improved recognition scores and decreased the magnitude of the differences in scores between combinations. This suggested a synergistic effect among E cues from different frequency regions. The mean weights of E cues of frequency regions 1–5 were 0.31, 0.19, 0.26, 0.22, and 0.02, respectively.ConclusionFor Mandarin disyllabic words, E cues of frequency regions 1 (80–502 Hz) and 3 (1,022–1,913 Hz) contributed more to word recognition than other regions, while frequency region 5 (3,856–7,562) contributed little.
Clinical and Genetic Predictive Models for the Prediction of Pathological Complete Response to Optimize the Effectiveness for Trastuzumab Based Chemotherapy
Authors: Li Lun , Chen Min , Zheng Shuyue , Li Hanlu , Chi Weiru , Xiu Bingqiu , Zhang Qi , Hou Jianjing , Wang Jia , Wu Jiong 
Published: July 2021

BackgroundTrastuzumab shows excellent benefits for HER2+ breast cancer patients, although 20% treated remain unresponsive. We conducted a retrospective cohort study to optimize neoadjuvant chemotherapy and trastuzumab treatment in HER2+ breast cancer patients.MethodsSix hundred patients were analyzed to identify clinical characteristics of those not achieving a pathological complete response (pCR) to develop a clinical predictive model. Available RNA sequence data was also reviewed to develop a genetic model for pCR.ResultsThe pCR rate was 39.8% and pCR was associated with superior disease free survival and overall survival. ER negativity and PR negativity, higher HER2 IHC scores, higher Ki-67, and trastuzumab use were associated with improved pCR. Weekly paclitaxel and carboplatin had the highest pCR rate (46.70%) and the anthracycline+taxanes regimen had the lowest rate (11.11%). Four published GEO datasets were analyzed and a 10-gene model and immune signature for pCR were developed. Non-pCR patients were ER+PR+ and had a lower immune signature and gene model score. Hormone receptor status and immune signatures were independent predictive factors of pCR.ConclusionHormone receptor status and a 10-gene model could predict pCR independently and may be applied for patient selection and drug effectiveness optimization.
Suicidality Presented to a Child and Adolescent Psychiatry Emergency Service: Increasing Rate and Changing Characteristics
Authors: Kandsperger Stephanie , Jarvers Irina , Schleicher Daniel , Ecker Angelika , Wirth Michael , Brunner Romuald 
Published: July 2021

Background: Children and adolescents who present to child and adolescent psychiatric emergency departments show a variety of reasons for their presentations. Suicidality, in particular suicidal thoughts and suicide attempts, as well as non-suicidal self-injury (NSSI) play a large and important role. In this context, inpatient admissions frequently serve as crisis intervention.Methods: In this study, face-to-face emergency presentations to the emergency department at our Clinic of Child and Adolescent Psychiatry (CAP) were analyzed over the years 2014-2018, the 4th quarter (October-December) of each year. Data from 902 emergency presentations were evaluated, primarily with regard to suicidal thoughts, suicide attempts, and NSSI as reasons for presentation.Results: Data demonstrated that the number of emergency presentations increased in general and especially for suicidal thoughts and NSSI as reasons for presentation. In addition, suicidal thoughts, suicide attempts, and NSSI as reasons for emergency presentation were more likely to result in crisis-related inpatient admissions. Furthermore, reporting suicide attempts at emergency presentation was associated with longer inpatient stays. Finally, cases with multiple diagnoses increased independent of the general increase in emergency presentations.Conclusion: The increase of utilization of clinics with CAP outpatient emergency patients and following admissions to the inpatient units for crisis intervention poses a major challenge for the future. It is important to prepare for the assessment and treatment of suicidality, which is of extraordinary importance in the care of emergency patients.
Perception in Black and White: Effects of Intonational Variables and Filtering Conditions on Sociolinguistic Judgments With Implications for ASR
Authors: Holliday Nicole R. 
Published: July 2021

This study tests the effects of intonational contours and filtering conditions on listener judgments of ethnicity to arrive at a more comprehensive understanding on how prosody influences these judgments, with implications for austomatic speech recognition systems as well as speech synthesis. In a perceptual experiment, 40 American English listeners heard phrase-long clips which were controlled for pitch accent type and focus marking. Each clip contained either two H* (high) or two L+H* (low high) pitch accents and a L-L% (falling) boundary tone, and had also previously been labelled for broad or narrow focus. Listeners rated clips in two tasks, one with unmodified stimuli and one with stimuli lowpass filtered at 400 Hz, and were asked to judge whether the speaker was “Black” or “White”. In the filtered condition, tokens with the L+H* pitch accent were more likely to be rated as “Black”, with an interaction such that broad focus enhanced this pattern, supporting earlier findings that listeners may perceive African American Language as having more variation in possible pitch accent meanings. In the unfiltered condition, tokens with the L+H* pitch accent were less likely to be rated as Black, with no effect of focus, likely due to the fact that listeners relied more heavily on available segmental information in this condition. These results enhance our understanding of cues listeners rely on in making social judgments about speakers, especially in ethnic identification and linguistic profiling, by highlighting perceptual differences due to listening environment as well as predicted meaning of specific intonational contours. They also contribute to our understanding of the role of how human listeners interpret meaning within a holistic context, which has implications for the construction of computational systems designed to replicate the properties of natural language. In particular, they have important applicability to speech synthesis and speech recognition programs, which are often limited in their capacities due to the fact that they do not make such holistic sociolinguistic considerations of the meanings of input or output speech.
Treatment of Chronic Traumatic Diaphragmatic Hernia Based on Laparoscopic Repair: Experiences From 23 Cases
Authors: Liu Qiaonan , Luan Li , Zhang Guangyong , Li Bo 
Published: July 2021

Background: We aimed to investigate the safety and effectiveness of laparoscopic repair for treating chronic traumatic diaphragmatic hernia (CTDH).Methods: In this retrospective analysis, we included 23 cases with CTDH underwent laparoscopy in our hospital between June 2015 and October 2019 was performed. The patient characteristics were recorded. We compared the diameter of hernia ring, surgery duration, intraoperative bleeding volume, means of repairing, as well as the follow-up data.Results: All the patients underwent laparoscopic diaphragmatic hernia repair, without conversion to laparotomy or thoracotomy. The operation time ranged from 60 min to 200 min (mean, 108.04 ± 42.93 min). The blood loss volume ranged from 10 to 300 ml (mean volume, 63.48 ± 71.69 ml). The postoperative hospital stayed ranged from 5 to 15 days (mean, 6.22 ± 2.11 days). The patients were followed up for 1–50 months (mean, 17.5 ± 10.90 months). No recurrence of diaphragmatic hernia was found.Conclusions: Laparoscopic repair of CTDH is featured by fast recovery, high security, and effectiveness. Reducing the hernia contents and close of the hernia ring are crucial for the surgery that is performed based on the size and location of the diaphragmatic hernia.
ANALYSIS AND FORMATION OF THE STRUCTURE OF THE INTERNET OF THINGS NETWORK BASED ON LATTICE MODELS
Authors: БУШЕЛЕНКОВ С.Н. , ПАРАМОНОВ А.И. 
Published: July 2021

Приведены результаты анализа и моделирования беспроводной сети интернета вещей в многоэтажном строении. Получено выражение для отношения сигнал/помеха (ОСП) при размещении узлов сети в виде регулярной структуры, представляющей простую кубическую решетку. Приведены зависимости ОСП от интенсивности трафика и количества узлов сети в строении. Рассмотрена возможность применения теории перколяции при описании функциональных возможностей сети.
The article presents the results of the analysis and modeling of a wireless network of the Internet of Things in a multi-story building. In the proposed model, an expression is obtained for the signal-to-noise ratio when locating network nodes in the form of a regular structure representing a simple cubic lattice. The dependences of the signal-to-interference ratio on the traffic intensity and the number of network nodes in the multistory building are obtained. The possibility of applying the theory of percolation in describing the functionality of the network is also considered.
UNIVERSAL INVARIANT ECHOCOMPENSATION METHOD IN DUPLEX COMMUNICATION SYSTEMS
Authors: ЛЕБЕДЯНЦЕВ В.В. , ПАВЛОВ И.И. , АБРАМОВ С.С. , ЛЕБЕДЯНЦЕВ М.В. , ПАВЛОВА М.С. , АБРАМОВА Е.С. 
Published: July 2021

Предлагается универсальный метод эхокомпенсации в дуплексных системах связи, инвариантный относительно амплитудной характеристики паразитного эхотракта устройств разделения направлений передачи. Теоретическое обоснование метода базируется на отображении линейных и нелинейных измерений сигналов передатчика в эхотракте проективной группой преобразований и использовании инварианта этой группы для расчета копий сигналов передатчика на выходе эхотракта.
It is proposed the universal method of echocompensation in duplex communication systems, which is invariant with respect to the amplitude characteristic of the parasitic echo path of transmission direction separation devices. The theoretical justification of the method is based on the mapping of linear and nonlinear measurements of the transmitter signals in the echo path by a projective group of transformations and using the invariant of this group to calculate copies of the transmitter signals at the output of the echo path.
GAMBARAN PENGETAHUAN REMAJA MENGENAI BAHAYA HAMIL USIA DINI PADA SISWI DI SMA SEI PUTIH KECAMATAN TAPUNG KABUPATEN KAMPAR TAHUN 2021
Authors: Marlita Lora , Roza Andalia , Dewi Ariana 
Published: July 2021

ABSTRAK
Kehamilan adalah fertilisasi atau penyatuan dari spermatozoa dan ovum dilanjutkan dengan nidasi atau implantasi. Bisa dihitung dari saat fertilisasi hingga lahirnya bayi, kehamilan normal akan berlangsung dalam waktu 40 minggu. Tujuan penelitian ini untuk mengetahui Gambaran Pengetahuan Remaja Mengenai Bahaya Hamil Usia Dini Di SMA Sei Putih Kecamatan Tapung Kabupaten Kampar Tahun 2021. Menggunakan jenis penelitian deskriptif kuantitatif. Populasi dalan penelitian ini yaitu siswi SMA Sei Putih sebanyak 52 orang. Teknik pengambilan sampel pada penelitian ini dengan menggunakan teknik quota sampling dimana peneliti mengambil sampel sesuai dengan yang ditargetkan atau diinginkan. Instrumen penelitian menggunakan kuesioner skala Guttman yang terdiri dari 20 pertanyaan. Analisa data menggunakan analisa univariat. Diketahui tingkat pengetahuan pada penelitian ini yaitu cukup dengan jumlah 28 responden (53,84%).

Kata Kunci : Kehamilan, Siswi, Bahaya Hamil Usia Dini
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KUNJUNGAN LANSIA KE POSYANDU DI PUSKESMAS SELALONG KECAMATAN SEKADAU HILIR TAHUN 2020
Authors: Ritayani Ritayani , Hariana Evy 
Published: July 2021

Posyandu lansia merupakan program pelayanan kesehatan lansia tingkat dasar untuk menjaga kualitas hidup lansia menjadi lebih baik melalui kegiatan preventif, kuratif, dan rehabilitatif seperti pelayanan pemeriksaan kesehatan lansia. Penelitian ini bertujuan untuk mengetahui Faktor-Faktor yang Berhubungan dengan Kunjungan Lansia ke Posyandu di Puskesmas Selalong Kecamatan Sekadau Hilir. Penelitan ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Jumlah sampel 64 lansia. Teknik pengambilan Sampel total sampling. Instrumen penelitian menggunakan kuesioner. Hasil Penelitian dengan analisis bivariat (uji Chi Square) diketahui ada hubungan antara pengetahuan (p-value = 0,037), Sikap (p-value = 0,023) dan Dukungan keluarga (p-value = 0,011) dengan Kunjungan Lansia ke Posyandu. Tidak ada hubungan antara pendidikan (p-value = 0,605 dengan uji Fisher's Exact) dan tokoh masyarakat (p-value = 0,118) dengan Kunjungan Lansia ke Posyandu di Puskesmas Selalong Kecamatan Sekadau Hilir. Faktor-Faktor yang berhubungan dengan kunjungan lansia ke Posyandu di Puskesmas Selalong Kecamatan Sekadau Hilir adalah pengetahuan, sikap dan dukungan keluarga lansia. Disarankan agar semua pihak dapat memberikan edukasi tentang Gizi sehat bagi lansia. Memberikan motivasi bagi lansia untuk lebih aktif dalam mengikuti posyandu lansia.