bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Response Optimisation of Automotive Door Using Grey Relational Analysis with Entropy Weights
Authors: Chen Hao , Lu Chihua , Liu Zhien , Shen Cunrui , Sun Menglei 
Published: December 2021

Abstract
Tail-welded blanks (TWBs) are widely used in automotive bodies to improve structural performance and reduce weight. The stiffness and modal lightweight design optimisation of TWBs for automotive doors was performed in this study. The finite element model was validated through physical experiments. An L27 (312) Taguchi orthogonal array was used to collect the sample points. The multi-objective optimisation problem was transformed into a single-objective optimisation problem based on the grey relational degree. The optimal combination of structural design parameters was obtained for a tail-welded door using the proposed method; the weight of the door structure was reduced by 2.83 kg. The proposed optimisation method has fewer iterations and a lower computational cost, enabling the design of lightweight TWBs.
Safe femoral condyle range for the reverse Rigidfix femoral fixation device in anterior cruciate ligament reconstruction
Authors: Luo Zhongliu , Hu Yong , Han Qingmin , Gao Zhi , Cheng Songmiao 
Published: December 2021

Abstract
Background: To determine the characteristics of cross-pin protrusion in patients treated with the reverse Rigidfix femoral fixation device for femoral tunnel preparation through the anteromedial portal in ACLR, analyse the reasons for this outcome, and identify safety hazards of this surgical technique for improvement. Methods: A retrospective analysis of patients who underwent ACLR using this technology at our hospital in 2018 was conducted. Patients with and without cross-pin protrusion were included in the case and control groups, respectively. The sex, age and imaging characteristics of the patients with cross-pin protrusion were identified, and the reasons for cross-pin protrusion were analysed. Results: There were 64 and 212 patients in the case and control groups, respectively. The proportion of cross-pin protrusion cases was 23.19% (64/276). There was a significant difference in the ratio of males to females (P <0.001, χ2=185.184), the mediolateral femoral condyle diameter (case group, 70.59 ±2.51 mm; control group, 82.65±4.16 mm; P <0.001, t=28.424), and the anteroposterior diameter of the lateral femoral condyle (case group, 58.34±2.89 mm; control group, 66.38±3.53 mm; P <0.001, t=16.615). The cross-pins did not penetrate the lateral femoral condyle cortex in patients with a mediolateral femoral condyle diameter ≥76 mm, but the cross-pins definitely penetrated the cortex when the diameter was ≤70 mm. The cross-pins did not penetrate when the anteroposterior lateral femoral condyle diameter was ≥66 mm, but the cross-pins definitely penetrated it when the diameter was ≤59 mm. Conclusion: The patients with cross-pin protrusion after reverse Rigidfix femoral fixation treatment to prepare the femoral tunnel through the anteromedial portal in ACLR were mainly females with small femoral condyles. For patients with a mediolateral femoral condyle diameter ≥76 mm and an anteroposterior lateral femoral condyle diameter ≥ 66 mm, there is no risk of cross-pin protrusion, so this technique can be used with confidence.
Alkali Cation Effect on CO2 Electroreduction to CO: A Local Colligative Property
Authors: Shin Seung-Jae , Choi Hansol , Ringe Stefan , Won Da Hye , Choi Chang Hyuck , Kim Hyungjun 
Published: December 2021

Abstract
Converting carbon dioxide (CO2) into valuable products is one of the most important processes for a sustainable society. Especially, the electrochemical CO2 reduction reaction (CO2RR) offers an effective means, but its reaction mechanism is not yet fully understood. Here, we demonstrate that cation-coupled electron transfer (CCET) is a rate-determining step in the CO2RR to carbon monoxide. The first-principles-based multiscale simulation identifies a single cation that coordinates a CO2− intermediate adsorbed on Ag electrode. The CCET is experimentally verified by a collapse of the CO2RR polarization curves upon correcting Nernstianly for a bulk cation concentration. As further confirmation, a kinetic study shows that the CO2RR obeys first-order kinetics on a local cation concentration. Finally, this work unveils that the cation effect on CO2RR originates from the local colligative property, and further highlights the importance of ion-pairing tendency for electrochemical interface design to achieve high-performance CO2 electrolysis.
Real-World Prescribing Pattern of Asthma Management in China: A Retrospective, Descriptive Analysis
Authors: Sun Jian , Wang Xin , Ma Xiaobin , Feng Yuyu , Wang Yajun , Wang Junren , Jiang Shujuan , Xing Chunyan 
Published: December 2021

Abstract
Background: Asthma is a chronic inflammatory disorder of the airway that requires long-term medication management. Objective: To describe the real-world prescribing patterns for asthma management in the Chinese population. Methods: A retrospective analysis of 8,732 patients from January 2011 to September 2019 in 10 hospitals was conducted. Prescribing patterns of short-acting beta-agonists (SABA), long-acting beta-agonists (LABA), inhaled corticosteroids (ICS), intravenous corticosteroids, antihistamines, leukotriene receptor antagonists (LTRA), theophylline, antibiotics, and Chinese patent medicines were included in the analysis. Chi-square and logistic regression were calculated. A P value of <0.05 was considered as statistical significance.Results: ICS/LABA were prescribed for 2,940 (33.67%) patients with stable asthma and 141 (31.4%) patients with asthma exacerbations. LTRA was prescribed in 2,006 (22.97%) patients with stable asthma, and 86 (19.15%) patients with asthma exacerbations. Systemic antibiotics (46.1Z%), systemic corticosteroids (57.91%), and theophylline (51.45%) were frequently prescribed during exacerbations. A total of 5,766 patients (64.95%) were managed with traditional Chinese medication (TCM); 3237 patients (36.47%) received western medicine. Patients using ICS/LABA (P=0.019) and SABA (P=0.008) had a significantly lower rate of asthma exacerbations.Conclusions: This study provides valuable insight into clinical practices of asthma management in China. Poor adherence to clinical reports was identified. Efforts are required to improve the quality of asthma care.
Amelioration of oxidative stress-mediated cytotoxicity and genotoxicity induced by copper and flubendiamide in-vivo and in- vitro by potent antioxidants
Authors: Mandil Rajesh , Prakash Atul , Rahal Anu , Koli Swati , Kumar Rahul , Garg Satish K. 
Published: December 2021

Abstract
Present study was designed to assess the toxicity of copper @ 33 mg/kg and flubendiamide @ 200 mg/kg in vivo in male Wistar rats orally once daily for 90 days and protective effect of α-tocopherol, resveratrol, curcumin and catechin and in vitro cyto-genotoxicity in primary cell culture of thymocytes. In vivo study showed significant (p<0.05) increase in AST, total bilirubin and uric acid, creatinine and BUN levels while decrease in total proteins, GSH, SOD and GST levels and increased LPO and GPx with severe degenerative changes were observed in liver and kidney tissues in intoxicated groups. In vitro thymocytes were exposed to 40 µM concentration of flubendiamide and/or showed significant increase in TUNEL+ve cells, micronuclei, DNA shearing, and comet formation per 100 cells. Concurrent treatment with α-tocopherol in xenobiotics intoxicated groups showed almost normal values of the biochemical parameters and decreased LPO production and improved antioxidant enzymes activities and histoarchitecture of liver and kidney tissues suggest ameliorative potential of α-tocopherol whereas, resveratrol, curcumin, catechin or α-tocopherol in vitro decreased TUNEL+ve cells, micronuclei induction and comet formation and effect of antioxidants was concentration-dependent and their order of potency on equimolar concentration (10 µM) basis is: curcumin > resveratrol >catechin = α-tocopherol.
WITHDRAWN: Research on Emergency Material Allocation Mode of Sudden Disaster with Improved NSGA-II
Authors: Tao Ning , Jiayu Wang , Yumeng Han 
Published: December 2021

Abstract
Background:In order to solve the problems of redundancy, unfairness, low satisfaction and high cost of emergency material allocation caused by unreasonable allocation effectively in the case of sudden disasters, and minimize the economic cost, punishment cost and maximizing the satisfaction rate of disaster victims, a 3-level network emergency material allocation mode based on big data is proposed in this paper.Methods:Taking the loss degree and the dynamic change of material demand in the disaster stricken areas as constraints, the demand forecasting, scheduling optimization, targeted allocation and disaster victims' satisfaction model based on emergency relief materials is constructed. The Sample Average Approximation method and improved NSGA-II algorithm are designed to solve the problem.Results:Compared with the results obtained by the improved NSGA-II, the value is significantly reduced. From the fairness evaluation results of the two model distribution schemes, the model obtained by the improved NSGA-II is more suitable for the distribution of emergency supplies with fair distribution requirements.Conclusions:It can be concluded that the 3-level network allocation mode and improved NSGA-II can solve emergency relief materials allocation based on big data effectively. The next step is to design scheduling model with all feasible medical supplies allocation route to improve the practicability of the model.
LncRNA AC008972.1 as a Novel Therapeutic Target for Prostate Cancer
Authors: Liu Jia , Wu Qijin , Song Ruiyu , Miao Wen , Ma Yuting , Yang Hongbao , Zeng Qingqi 
Published: December 2021

Abstract
Background: Prostate cancer is the leading cause of disease and death in men. Long non-coding RNAs (lncRNAs), microRNA (miRNAs) and mRNAs networks mediate prostate cancer progression. Here, we aim to investigate functions of lncRNA AC008972.1/miR-143-3p/thousand-and-one-amino acid 2 kinase (TAOK2) in prostate cancer. Methods: The expression levels of lncRNA AC008972.1, miR-143-3p and TAOK2 are detected in prostate cancer tissues and cell lines by RT-qPCR. PC3 and LNCaP cells are used to establish lncRNA AC008972.1-knockdown, miR-143-3p-overexpressing, and TAOK2-down-regulated cells. Cell viability is examined by MTT and cell proliferation is detected by clone formation assay. Cell migration and invasion are tested by wound scratch assay and transwell chamber assay. The rate of apoptosis was analyzed by flow cytometry. The protein expression is detected by western blot assay. The target is validated by RNA binding protein immunoprecipitation (RIP) assay and dual luciferase activity assay. A mouse xenograft model was conducted to investigate the oncogenic effect of lncRNA AC008972.1 on prostate cancer. Results: High expression of lncRNA AC008972.1 was associated with low overall survival in prostate cancer. Down-regulation of lncRNA AC008972.1 delayed prostate cancer process by inhibiting cell viability, proliferation, migration and invasion, as well as altering protein expression，whereas cell apoptosis was markedly promoted. LncRNA AC008972.1 negatively regulated miR-143-3p expression and miR-143-3p overexpression promoted prostate cancer process in vitro. TAOK2 expression was decreased by miR-143-3p through the complementary targeting of TAOK2 mRNA. Down-regulation of lncRNA AC008972.1 mitigated prostate cancer process in vitro based on miR-143-3p/TAOK2 node. Furthmore, the data of xenograft model experiment showed that inhibition of lncRNA AC008972.1 suppressed tumor growth in vivo. Conclusions: Collectively, knockdown of lncRNA AC008972.1 inhibits prostate cancer cell growth based on down-regulation of TAOK2 induced by miR-143-3p. Here, we identify that lncRNA AC008972.1 exerts essential roles in the progression of prostate cancer and serves as a novel therapeutic target for prostate cancer.
How Much Obesity and Diabetes Do Impair Male Fertility?
Authors: Abbasihormozi Shima , Kohkan Azam , Shahverdi Abdolhossein , Parhizkar Amir , Vesali Samira 
Published: December 2021

Abstract
BackgroundSubfertility in obese and diabetic men during the reproductive age is evident, but the mechanisms by which obesity and diabetes mellitus cause male infertility are not entirely understood. The current study aimed to evaluate the effects and potential mechanisms of obesity and diabetes on male fertilityMethodsWe enrolled control=40, obese=40, Lean-DM=35, and Obese-DM=35 individuals. The obesity-associated markers, diabetic markers, hormonal and lipid profile, inflammatory indices, and semen analysis were assessed in four experimental groups.ResultsOur finding showed that diabetic markers were significantly increased in two diabetic groups, while obesity indices were markedly increased in two obese groups. Conventional sperm parameters were significantly lower in three groups compared with the control. Serum levels of total testosterone and sex hormone-binding globulin were significantly lower in men with obesity and DM compared with the control. There was a significant difference in the concentration of high-sensitivity C-reactive protein among four experimental groups. Moreover, serum leptin was significantly increased in obese DM, lean DM, and obese groups. Serum insulin levels had a positive correlation with metabolic-associated indices and high-sensitivity C-reactive protein levels, whereas it had a negative correlation with count, motility, and morphology. Conclusions﻿Our findings showed the metabolic changes, hormonal dysfunction and inflammatory disturbance might be suspected mechanisms of subfertility in obese and diabetic subfertile men.
Factors Predicting Cardiac Arrest in the Intensive Care Unit: A Matched Case-Control Study
Authors: Sang Wentao , Pan Yuhui , Zhao Xue , Wu Shuo , Zheng Wen , Pan Chang , Zheng Jiaqi , Wei Shuxing , Zhang Yongsheng , Zhang Jian , Ma Jingjing , Chen Yuguo , Xu Feng 
Published: December 2021

Abstract
Background: Early detection and intervention of disease deterioration are the keys to reducing the incidence of preventable intensive care unit cardiac arrest (ICU-CA). We aimed to investigate the ICU-CA predictive factors, including vital signs and laboratory indicators, and to analyze the performance of trends value of those factors on predicting ICU-CA. Methods: We conducted a matched case-control study at Qilu Hospital of Shandong University. Data on adult patients in ICU who suffered a cardiac arrest (CA) were retrospectively collected from 2016 to 2019, including vital signs and laboratory indicators at 48, 36, 24, 12, and 8 hours before ICU-CA. These cases were matched (ward, sex, and admission data) with controls (no ICU-CA) at a 1:2 ratio. Univariable logistic regression was used for statistical comparisons between cases and controls, and multivariate logistic regression was used to investigate the independent associations of indicators and their tendency with ICU-CA at given time points. The area under receiver operating characteristic (AUROC) was used to evaluate the predictive performance on ICU-CA.Results: Of 6164 ICU patients, 1042 patients suffered an ICU-CA during the 3 years. After careful screening, a total of 427 patients were included as the cases in the study, and 790 patients were included as controls. The vital signs and laboratory indicators at 8h before cardiac arrest, such as heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), oxygen saturation (SaO2), hemoglobin (HGB), potassium (K+), sodium (Na+), lactic acid (Lac), and pH all can predict the ICU-CA. The mean value, maximum value, minimum value, and range of these indicators were related to the occurrence of ICU-CA, and the trend values were more accurate than the current value for the variability in laboratory indicators. Conclusions: The ability of trends value of laboratory indicators for predicting ICU-CA was more accurate than the value at given time points for the variability in laboratory indicators. Adding trends of laboratory indicators may increase the accuracy of models designed to detect critical illness in ICU. Trial registration: ClinicalTrials.gov Identifier: NCT04670458.
JAC1 Targets YY1-Mediated JWA/p38 MAPK Signaling To Inhibit Proliferation and Induce Apoptosis In TNBC
Authors: Zhai Zurong , Ren Yanlin , Shu Chuanjun , Chen Dongyin , Liu Xia , Liang Yan , Li Aiping , Zhou Jianwei 
Published: December 2021

Abstract
Background: Triple negative breast cancer (TNBC) is a type of breast cancer with poor prognosis, and still has no adequate therapeutic target and ideal medicine. The public database and the relative studies have shown that low expression of JWA is closely related to the poor overall survival in many cancers including breast cancer. However, the precise biological functions and behind mechanisms of JWA in TNBC are still unclear.Methods: Both TCGA and GEO databases were used to confirm the relationship between expression levels of JWA and overall survival in TNBC cases. JAC1, an agonistic small compound of JWA gene, was used in TNBC models in vitro and in vivo. The routine cellular and molecular assays include CCK-8, colony formation, EdU incorporation, the flow cytometry, Western blot, immunohistochemistry, immune-fluorescence microscopy and reporter gene assays were conducted in this study.Results: Low expression of JWA was associated with poor prognosis in TNBC patients. JAC1 treatment inhibited TNBC cells proliferation and promoted apoptosis in vitro and in vivo. JAC1 specifically combined and targeted YY1 to eliminate its transcriptional inhibition on JWA gene. At the same time, JAC1 promoted ubiquitination and degradation of YY1. The rescued JWA induced G1 phase arrest and apoptosis in TNBC cells through the p38 MAPK signaling pathway. In addition, JAC1 disrupted the interaction between YY1 and HSF1, and suppressed the oncogenic role of HSF1 in TNBC through p-Akt signaling pathway.Conclusions: We discovered for the first time that JAC1 is a YY1 targeting compound and maybe a potential therapeutic agent for TNBC.
Fuzzy Win-Win: A Novel Approach to Quantify Win-Win Using Fuzzy Logic
Authors: Hassanat Ahmad B. , Altarawneh Ghada A. , Tarawneh Ahmad S. 
Published: December 2021

Abstract
The classic win-win has a key flaw in that it cannot offer the parties with right amounts of winning because each party believes they are winners. In reality, one party may win more than the other. This strategy is not limited to a single product or negotiation; it may be applied to a variety of situations in life. We present a novel way to measure the win-win situation in this paper. The proposed method employs the Fuzzy logic to create a mathematical model that aids negotiators in quantifying their winning percentages. The model is put to the test on real-life negotiation scenarios such as the Iranian uranium enrichment negotiations, the Iraqi-Jordanian oil deal, and the iron ore negotiation (2005-2009). The presented model has shown to be a useful tool in practice and can be easily generalized to be utilized in other domains as well.
Determinants of Acute Respiratory Infection among Under-Five Children in Rural Ethiopia
Authors: Merera Amanuel Mengistu 
Published: December 2021

Abstract
Introduction: In low- and middle-income nations, acute respiratory infection (ARI) is the primary cause of morbidity and mortality. According to some studies, Ethiopia has a higher prevalence of childhood acute respiratory infection, ranging from 16 % to 33.5 %. The goal of this study was to determine the risk factors for acute respiratory infection in children under the age of five in rural Ethiopia. Methods: A cross-sectional study involving 7,911 children under the age of five from rural Ethiopia was carried out from January 18 to June 27, 2016. A two stage cluster sampling technique was used recruit study subjects and SPSS version 20 was used to extract and analyze data. A binary logistic regression model was used to identify factors associated with a childhood acute respiratory infection. The multivariable logistic regression analysis includes variables with a p-value less than 0.2 during the bivariate logistic regression analysis. Adjusted odds ratios were used as measures of effect with a 95% confidence interval (CI) and variables with a p-value less than 0.05 were considered as significantly associated with an acute respiratory infection. Results: The total ARI prevalence rate among 7,911 under-five children from rural Ethiopia was 7.8%, according to the findings of the study. The highest prevalence of ARI was found in Oromia (12.8 %), followed by Tigray (12.7 %), with the lowest frequency found in Benishangul Gumuz (2.4 %). A multivariable logistic regression model revealed that child from Poor household (AOR=2.170, 95% CI: 1.631-2.887), mother’s no education (AOR=2.050,95% CI: 1.017-4.133), mother’s Primary education (AOR=2.387, 95% CI:1.176-4.845), child had not received vitamin A (AOR=1.926, 95% CI:1.578-2.351), child had no diarrhea (AOR=0.257, 95% CI: 0.210-0.314), mothers not working (AOR=0.773, 95% CI:0.630-0.948), not stunted (AOR=0.663, 95% CI: 0.552-0.796), and not improved water source (AOR=1.715, 95% CI: 1.395-2.109). Similarly, among under-five children, the age of the child, the month of data collection, anemia status, and the province were all substantially linked to ARI. Conclusions: Childhood ARI morbidity is a serious health challenge in rural Ethiopia, according to this study, with demographic, socioeconomic, nutritional, health, and environmental factors all having a role. As a result, regional governments, healthcare staff, and concerned groups should place a priority on reducing ARI, and attempts to solve the issue should take these variables into account.