bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food security mediates the decrease in women’s depressive symptoms in a participatory nutrition-sensitive agroecology intervention in rural Tanzania
Authors: Cetrone Hollyn M , Santoso Marianne V , Bezner Kerr Rachel , Petito Lucia , Blacker Lauren , Nonga Theresia , Martin Haikael D , Kassim Neema , Mtinda Elias , Young Sera L 
Published: March 2021

AbstractObjective:To investigate if food security mediated the impact of a nutrition-sensitive agroecology intervention on women’s depressive symptoms.Design:We used annual longitudinal data (four time points) from a cluster-randomised effectiveness trial of a participatory nutrition-sensitive agroecology intervention, the Singida Nutrition and Agroecology Project. Structural equation modelling estimation of total, natural direct and natural indirect effects was used to investigate food security’s role in the intervention’s impact on women’s risk of probable depression (Center for Epidemiologic Studies Depression Scale > 17) across 3 years.Setting:Rural Singida, Tanzania.Participants:548 food insecure, married, smallholder women farmers with children < 1 year old at baseline.Results:At baseline, one-third of the women in each group had probable depression (Control: 32·0 %, Intervention: 31·9 %,Pdifference = 0·97). The intervention lowered the odds of probable depression by 43 % (OR = 0·57, 95 % CI: 0·43, 0·70). Differences in food insecurity explained approximately 10 percentage points of the effects of the intervention on odds of probable depression (OR = 0·90, 95 % CI: 0·83, 0·95).Conclusions:This is the first evidence of the strong, positive effect that lowering food insecurity has on reducing women’s depressive symptoms. Nutrition-sensitive agricultural interventions can have broader impacts than previously demonstrated, i.e. improvements in mental health; changes in food security play an important causal role in this pathway. As such, these data suggest participatory nutrition-sensitive agroecology interventions have the potential to be an accessible method of improving women’s well-being in farming communities.
Terrorist campaigns and the growth of the Muslim population
Authors: Choi Seung-Whan 
Published: March 2021

AbstractThe world population of Muslims has increased exponentially in the past decade. Why is the world's Muslim population growing so quickly? This study offers a new theoretical perspective: the growth of the worldwide Muslim population is a result of a series of terrorist campaigns that inspire non-Muslims to convert to Islam. For empirical testing, this study employs a cross-national, time-series analysis of 152 countries from 1970 to 2007. Although there is lack of data on conversions that follow terrorist campaigns for a direct test of the theory, this study finds a correlation between terrorist attacks and growth of the Muslim population. This finding is robust and consistent even after controlling for salient demographic reasons for growth, such as the level of fertility and immigration.
Climatic Drivers of Extreme Sea Level Events Along the Coastline of Western Australia
Authors: Lowe Ryan J. , Cuttler Michael V. W. , Hansen Jeff E. 
Published: March 2021

AbstractAccurate prediction of coastal flooding requires a detailed understanding of all individual contributions to sea level variability and how they interact to trigger extreme sea level (ESL) events. In this study, we focus on the expansive (∼10,000 km) coastline of Western Australia, a region that experiences large latitudinal gradients in met‐ocean sources of sea level variability, as a case study to investigate the mechanisms responsible for ESLs and trends over the past 54 years (1966–2019). Using long‐term sea level records from tide gauges and satellite altimetry, we explore how different contributions to sea level variability at different time scales (from hourly to interannual) interact to generate ESLs. We observe that all individual, nontidal contributions to ESLs (i.e., atmospheric surge, seasonal and interannual variability) are of similar magnitude (of order 10 cm) along the entire coast and comparable to the tidal variations in the microtidal southwestern region. The results reveal the important role that seasonal and interannual sea level variability plays in generating ESLs, with these low‐frequency contributions being relatively large compared to typical global values. With mean sea level having risen by ∼10 cm over this 54‐year study period, sea level rise was also identified as making an increasingly significant contribution to observed increases in the frequency of ESLs. Overall, due to the comparatively large magnitude of low‐frequency sea level contributions (seasonal and longer), the Western Australia coast provides a useful case study to investigate how sustained periods of elevated sea level will impact coastlines worldwide more broadly in the future.
Record of Neotectonics and Deep Crustal Fluid Circulation Along the Santa Fe Fault Zone in Travertine Deposits of the Lucero Uplift, New Mexico, USA
Authors: Garcia V. H. , Ma L. , Ricketts J. W. , Dosseto A. 
Published: March 2021

AbstractTravertine deposits preserve an invaluable record of both ancient and modern fluid flow. The goal of this study is to reconstruct spatial and temporal patterns in travertine deposition associated with tectonic and climatic controls along the Lucero Uplift in New Mexico, USA. Uranium‐series ages of travertine deposits in the Lucero Uplift range from 0.94 ± 0.01 to 592 ± 110 ka, indicating that travertine formation has been episodically active since at least ∼600 ka. We find minimal evidence to attribute glacial and interglacial cycles to travertine formation in the Lucero Uplift. δ13C values in travertine deposits range from 2‰ to 9‰ (Vienna Pee Dee Belemnite), δ18O values range from 21‰ to 25‰ (Vienna Standard Mean Ocean Water). Positive correlation between travertine δ13C and δ18O values indicate travertine formation is closely associated with various degrees of CO2 degassing. 87Sr/86Sr values in travertine deposits range from 0.714 to 0.717 and (234U/238U)i values exhibit a remarkably wide range from 3.6 to 9.3, indicative of fluid‐rock interaction during deep crustal circulation in more radiogenic basement rocks. Reconstructed δ13C, δ18O, and (234U/238U)i values in the inferred deep fluid sources showed systematic variations with travertine formation ages, while 87Sr/86Sr values remain relatively constant. Based on dating of undeformed travertine deposits, which overlie tilted Santa Fe Group units, and high (234U/238U)i we infer that the Santa Fe fault has not produced a ground‐rupturing earthquake within the last 490 ± 52 to 592 ± 110 ka (2σ). Our study suggest that travertine formation is driven by fluid flow facilitated by tectonic and mantle structures.
The Thermospheric Column O/N2 Ratio
Authors: Meier R. R. 
Published: March 2021

AbstractMore than 2 decades ago, D. J. Strickland and colleagues proposed use of the O/N2 column number density ratio as a new geophysical quantity to interpret thermospheric processes recorded in far ultraviolet (FUV) images of the Earth. This concept has enabled multiple advances in understanding the global behavior of Earth's thermosphere. Nevertheless, confusion remains about the conceptual meaning of the column density ratio, and in the application of this integral quantity. This is so even though it is now a key thermospheric measurement made by current and planned far ultraviolet remote sensing missions in pursuit of new understanding of thermospheric processes and variability. The intent here is to review the historical context of the O/N2 column density ratio, clarify its physical meaning, and resolve misunderstandings evident in the literature. Simple examples elucidate its original derivation for extracting column O/N2 ratios from measurements of the OI 135.6 nm/N2 Lyman‐Birge‐Hopfield (LBH) emission based on an algorithmic synthesis of model precomputations. These are organized in the form of a table lookup of column density ratio as a function of observed radiance ratios. To accommodate generalized solar‐geophysical and viewing conditions, the table required to specify the number of needed parameters becomes large. Proposed as an alternative is a simplified, first principles approach to obtaining the column density ratio from the emission ratio. This new methodology is now being applied successfully to FUV measurements made from onboard the Ionospheric CONnection satellite and will be applied retrospectively to the Global Ultraviolet Imager data.
Analyzing Low Frequency Seismic Events at Cerberus Fossae as Long Period Volcanic Quakes
Authors: Kedar Sharon , Panning Mark P. , Smrekar Suzanne E. , Stähler Simon C. , King Scott D. , Golombek Matthew P. , Manga Michael , Julian Bruce R. , Shiro Brian , Perrin Clement , Power John A. , Michaut Chloe , Ceylan Savas , Giardini Domenico , Lognonné Philippe H. , Banerdt William B. 
Published: March 2021

AbstractThe InSight Mission began acquiring the first seismic data on Mars in early 2019 and has detected hundreds of events. The largest events recorded to date originate at Cerberus Fossae, a young volcanic region characterized by high volume, low viscosity lava flows. A handful of Low Frequency (LF) quakes that share key attributes of Long Period quakes recorded on Earth's volcanoes are also traced to Cerberus Fossae. This study explores whether a traditional volcanic source model that simulates the generation of tremor as pressurized fluid makes its way through a channel at depth, can explain these atypical LF events. We consider a wide range of physical parameters including fluid viscosity, the ratio of driving pressure to lithostatic pressure, aspect ratio of the channel, and the equilibrium channel opening. We find that the model can produce the observed seismic signature, with a combination of low‐viscosity magma and high volume flux of ∼104 − 105 m3/s that are within an order‐of‐magnitude agreement with Cerberus Fossae lava flow properties deduced from analysis of lava flow dimensions. It is impossible, however, at this stage to conclude whether or not this is a likely explanation for Mars, as the model results in fluxes that are extreme for Earth yet are just within bounds of what has been inferred for Cerberus Fossae. We therefore conclude that we cannot rule out active magma flow as the mechanism responsible for the atypical LF events that likely originate from Cerberus Fossae.
Speleothem‐Based Hydroclimate Reconstructions During the Penultimate Deglaciation in Northern China
Authors: Xue Gang , Cai Yanjun , Lu Yanbin , Ma Le , Cheng Xing , Liu Chengcheng , Yan Hong , Sun Youbin , Li Dong , Wei Yingying , Huang Shouyi , He Mei , Cheng Hai , Edwards R. Lawrence 
Published: March 2021

AbstractTrace elements in a speleothem have been considered to be effective proxies to characterize hydroclimatic changes. In this study, we present speleothem trace element records of the penultimate glacial‐interglacial transition from 138 to 125.8 ka BP from the Shangxiaofeng cave in northeastern China. We used two analytical methods, namely, inductively coupled plasma optical emission spectrometry (ICP‐OES) and the Avaatech high‐resolution X‐ray fluorescence (XRF) core scanner. Both methods showed good consistency for Sr/Ca but not for Mg/Ca because of the high Mg detection limit of XRF. By comparing the trace element ratios (Sr/Ca and Mg/Ca) with δ13C and by analyzing the slope of the regression line of ln(Sr/Ca) versus ln(Mg/Ca), we found that trace element variations were dominated by hydroclimate‐related prior calcite precipitation (PCP) and water‐rock interaction (WRI). A gradually decreasing trend of Sr/Ca, Mg/Ca, and δ13C records during the glacial‐interglacial transition indicated that the hydroclimate moved toward a moist condition with an intensified East Asian summer monsoon (EASM) and transgression of the coastline. The transgression shortened the distance between the cave site and the coastline, possibly contributing to persistent rainfall enhancement at the study site.
Extreme‐Event Magnetic Storm Probabilities Derived From Rank Statistics of Historical Dst Intensities for Solar Cycles 14–24
Authors: Love Jeffrey J. 
Published: March 2021

AbstractA compilation is made of the largest and second‐largest magnetic‐storm‐maximum intensities, −Dst1 and −Dst2, for solar cycles 14–24 (1902–2016) by sampling Oulu Dcx for cycles 19–24, using published −Dstm values for 4 intense storms in cycles 14, 15, and 18 (1903, 1909, 1921, 1946), and calculating 15 new storm‐maximum −Dstm values (reported here) for cycles 14–18. Three different models are fitted to the cycle‐ranked −Dst1 and −Dst2 values using a maximum‐likelihood algorithm: A Gumbel model, an unconstrained Generalized‐Extreme‐Value model, and a Weibull model constrained to have a physically justified maximum storm intensity of −Dstm = 2500 nT. All three models are good descriptions of the data. Since the best model is not clearly revealed with standard statistical tests, inference is precluded of the source process giving rise to storm‐maximum −Dstm values. Of the three candidate models, the constrained Weibull gives the lowest superstorm occurrence probabilities. Using the compiled data and the constrained Weibull model, a once‐per‐century storm intensity is estimated to be −Dst1 = 663 nT, with a bootstrap 68% confidence interval of [497, 694] nT. Similarly, the probability that a future storm will have an intensity exceeding that of the March 1989 superstorm, −Dstm > 565 nT, is 0.246 per cycle with a 68% confidence interval of [0.140, 0.311] per cycle. Noting (possibly slight) ambiguity in the rankings of storm intensities, using the same methods, but storms more intense than those identified for cycles 14–16, would yield a higher once‐per‐century intensity and a higher probability for a −Dstm > 565 nT storm.
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors
Authors: Grohmann Christoph , Walker Francesca , Devlin Mark , Luo Meng-Xiao , Chüeh Anderly C. , Doherty Judy , Vaillant François , Ho Gwo-Yaw , Wakefield Matthew J. , Weeden Clare E. , Kamili Alvin , Murray Jayne , Po’uha Sela T. , Weinstock Janet , Kane Serena R. , Faux Maree C. , Broekhuizen Esmee , Zheng Ye , Shield-Artin Kristy , Kershaw Nadia J. , Tan Chin Wee , Witchard Helen M. , Ebert Gregor , Charman Susan A. , Street Ian , Kavallaris Maria , Haber Michelle , Fletcher Jamie I. , Asselin-Labat Marie-Liesse , Scott Clare L. , Visvader Jane E. , Lindeman Geoffrey J. , Watson Keith G. , Burgess Antony W. , Lessene Guillaume 
Published: March 2021

AbstractTargeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance and high cost. New small molecules which kill a wide range of cancer subtypes, with good therapeutic window in vivo, have the potential to complement the current arsenal of anti-cancer agents and deliver improved safety profiles for cancer patients. We describe results with a new anti-cancer small molecule, WEHI-7326, which causes cell cycle arrest in G2/M, cell death in vitro, and displays efficacious anti-tumor activity in vivo. WEHI-7326 induces cell death in a broad range of cancer cell lines, including taxane-resistant cells, and inhibits growth of human colon, brain, lung, prostate and breast tumors in mice xenografts. Importantly, the compound elicits tumor responses as a single agent in patient-derived xenografts of clinically aggressive, treatment-refractory neuroblastoma, breast, lung and ovarian cancer. In combination with standard-of-care, WEHI-7326 induces a remarkable complete response in a mouse model of high-risk neuroblastoma. WEHI-7326 is mechanistically distinct from known microtubule-targeting agents and blocks cells early in mitosis to inhibit cell division, ultimately leading to apoptotic cell death. The compound is simple to produce and possesses favorable pharmacokinetic and toxicity profiles in rodents. It represents a novel class of anti-cancer therapeutics with excellent potential for further development due to the ease of synthesis, simple formulation, moderate side effects and potent in vivo activity. WEHI-7326 has the potential to complement current frontline anti-cancer drugs and to overcome drug resistance in a wide range of cancers.
Universal method for magnetic skyrmion bubble generation by controlling the stripe domain instability
Authors: Moon Kyoung-Woong , Yang Seungmo , Ju Tae-Seong , Kim Changsoo , Chun Byoung Sun , Park Sungkyun , Hwang Chanyong 
Published: March 2021

AbstractMagnetic skyrmions, which are topological swirling spin textures, have drawn much attention in spintronics because of their use as an information carrier with distinct robustness rooted in their topological nature. Real-time generation of skyrmions is therefore imperative for realizing skyrmion-based spintronic devices. However, to date, experimental demonstration has been limited to exquisite works with well-tuned samples. Here, we report a method to generate skyrmions by driving the stripe instability via an in-plane magnetic field. We have demonstrated that the key parameter determining the stripe domain instability is the stripe width, regardless of other material parameters. This skyrmion generation method can be applicable to generic magnetic films with perpendicular magnetic anisotropy. Our work will facilitate the development of skyrmion-based devices by offering a general method for controlling a large skyrmion population.
Discovery of fungal surface NADases predominantly present in pathogenic species
Authors: Strømland Øyvind , Kallio Juha P. , Pschibul Annica , Skoge Renate H. , Harðardóttir Hulda M. , Sverkeli Lars J. , Heinekamp Thorsten , Kniemeyer Olaf , Migaud Marie , Makarov Mikhail V. , Gossmann Toni I. , Brakhage Axel A. , Ziegler Mathias 
Published: March 2021

AbstractNicotinamide adenine dinucleotide (NAD) is a key molecule in cellular bioenergetics and signalling. Various bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, we report the identification of NADases on the surface of fungi such as the pathogen Aspergillus fumigatus and the saprophyte Neurospora crassa. The enzymes harbour a tuberculosis necrotizing toxin (TNT) domain and are predominately present in pathogenic species. The 1.6 Å X-ray structure of the homodimeric A. fumigatus protein reveals unique properties including N-linked glycosylation and a Ca2+-binding site whose occupancy regulates activity. The structure in complex with a substrate analogue suggests a catalytic mechanism that is distinct from those of known NADases, ADP-ribosyl cyclases and transferases. We propose that fungal NADases may convey advantages during interaction with the host or competing microorganisms.
Ultrafast multi-cycle terahertz measurements of the electrical conductivity in strongly excited solids
Authors: Chen Z. , Curry C. B. , Zhang R. , Treffert F. , Stojanovic N. , Toleikis S. , Pan R. , Gauthier M. , Zapolnova E. , Seipp L. E. , Weinmann A. , Mo M. Z. , Kim J. B. , Witte B. B. L. , Bajt S. , Usenko S. , Soufli R. , Pardini T. , Hau-Riege S. , Burcklen C. , Schein J. , Redmer R. , Tsui Y. Y. , Ofori-Okai B. K. , Glenzer S. H. 
Published: March 2021

AbstractKey insights in materials at extreme temperatures and pressures can be gained by accurate measurements that determine the electrical conductivity. Free-electron laser pulses can ionize and excite matter out of equilibrium on femtosecond time scales, modifying the electronic and ionic structures and enhancing electronic scattering properties. The transient evolution of the conductivity manifests the energy coupling from high temperature electrons to low temperature ions. Here we combine accelerator-based, high-brightness multi-cycle terahertz radiation with a single-shot electro-optic sampling technique to probe the evolution of DC electrical conductivity using terahertz transmission measurements on sub-picosecond time scales with a multi-undulator free electron laser. Our results allow the direct determination of the electron-electron and electron-ion scattering frequencies that are the major contributors of the electrical resistivity.
Compensation-free high-dimensional free-space optical communication using turbulence-resilient vector beams
Authors: Zhu Ziyi , Janasik Molly , Fyffe Alexander , Hay Darrick , Zhou Yiyu , Kantor Brian , Winder Taylor , Boyd Robert W. , Leuchs Gerd , Shi Zhimin 
Published: March 2021

AbstractFree-space optical communication is a promising means to establish versatile, secure and high-bandwidth communication between mobile nodes for many critical applications. While the spatial modes of light offer a degree of freedom to increase the information capacity of an optical link, atmospheric turbulence can introduce severe distortion to the spatial modes and lead to data degradation. Here, we demonstrate experimentally a vector-beam-based, turbulence-resilient communication protocol, namely spatial polarization differential phase shift keying (SPDPSK), that can reliably transmit high-dimensional information through a turbulent channel without the need of any adaptive optics for beam compensation. In a proof-of-principle experiment with a controllable turbulence cell, we measure a channel capacity of 4.84 bits per pulse using 34 vector modes through a turbulent channel with a scintillation index of 1.09, and 4.02 bits per pulse using 18 vector modes through even stronger turbulence corresponding to a scintillation index of 1.54.
Cell kinetics of auxin transport and activity in Arabidopsis root growth and skewing
Authors: Hu Yangjie , Omary Moutasem , Hu Yun , Doron Ohad , Hoermayer Lukas , Chen Qingguo , Megides Or , Chekli Ori , Ding Zhaojun , Friml Jiří , Zhao Yunde , Tsarfaty Ilan , Shani Eilon 
Published: March 2021

AbstractAuxin is a key regulator of plant growth and development. Local auxin biosynthesis and intercellular transport generates regional gradients in the root that are instructive for processes such as specification of developmental zones that maintain root growth and tropic responses. Here we present a toolbox to study auxin-mediated root development that features: (i) the ability to control auxin synthesis with high spatio-temporal resolution and (ii) single-cell nucleus tracking and morphokinetic analysis infrastructure. Integration of these two features enables cutting-edge analysis of root development at single-cell resolution based on morphokinetic parameters under normal growth conditions and during cell-type-specific induction of auxin biosynthesis. We show directional auxin flow in the root and refine the contributions of key players in this process. In addition, we determine the quantitative kinetics of Arabidopsis root meristem skewing, which depends on local auxin gradients but does not require PIN2 and AUX1 auxin transporter activities. Beyond the mechanistic insights into root development, the tools developed here will enable biologists to study kinetics and morphology of various critical processes at the single cell-level in whole organisms.