bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Science, Technology, Engineering, and Mathematics (STEM) Approaches on Critical Thinking Skills Using PBL Learning Models
Authors: Setia Permana I Putu Yogi , Nyeneng I Dewa Putu , Distrik I Wayan 
Published: March 2021

The purpose of this study was to determine the effect of Science, Technology, Engineering, and Mathematics (STEM) approach to the improvement of critical thinking skills using Problem Based Learning (PBL) models. The population of the research was all of the 10th grade IPA students in SMA Negeri 7 Bandar Lampung which were 233 students. The selection of research sample used a purposive sampling technique with the sample of class X IPA 5 that consisted of 31 students as the experimental group and the class X IPA 6, which was 30 students, as the control group. The research design used Non-Equivalent Pretest Posttest Control Group Design. Data were tested by N-gain analysis, normality test, homogeneity test, Mann-Withney U Test Effect size test. The results showed that there was a significant effect of the STEM approach in improving critical thinking skills as indicated by the Sig. (2-Tailed), which was less than 0.05, 0.000, and the average value of N-gain (g) critical thinking skills in the experimental class was 0.73 (high category) while the control class was 0.56 (medium category). Effect size showed a value (d) of 1.49 included in high category. It can be concluded that the application of STEM approach using PBL learning model can improve students critical thinking skills. Implications of the study are discussed. The use of the STEM approach using PBL learning model can be used as an alternative for teachers as an effort to improve students' critical thinking skills.
Identification of Physics Concepts in Reog Ponorogo’s Dhadak Merak Dance as A Source of Learning Physics: An Analytical Study
Authors: Wulansari Nur Iva , Admoko Setyo 
Published: March 2021

Indonesia is famous for its diverse cultures, and unwittingly from each culture has a different appeal. In the culture itself, there is a science that is not widely known by people, besides local wisdom from several regions can be used as a source of learning science. So far, science learning, especially in physics, still refers only to a handbook of teachers and students, where it contains science products in the form of facts, concepts, principles, theories, and laws and their application in the context of daily life. However, many books often contain contexts of daily life related to western culture that is not well recognized by Indonesian children, especially those in certain areas who still rely on nature as a learning media. Based on these problems, the aim to observe the application of physics in Indonesia's national culture. The researcher intended to identify the concept of equilibrium and moments force in the technique of the Dhadak Merak dance movement in Reog Ponorogo. This type of research is an analytical study by using documentation studies and the research target is Dhadak Merak Dance. Data collected by the observation method and analysis method using literature study and training video. According to the results of the research, physics concept studies were obtained, especially in equilibrium materials and moments force in the Dhadak Merak Dance, and learning with an ethnoscience approach has the potential for innovation learning to be applied in physics learning because it can train students science literacy and train students to think creatively.
The Development of Oil-Fueled Gas Steam Stove as a Learning Media to Enhance Students' Curiosity
Authors: Untara Ketut Alit Adi , Gustina Gustina , Paramita Ielda 
Published: March 2021

This study aims to develop learning media in the form of gas steam stoves fueled by oil and describe the validity and effectiveness of the products being developed. This development and research are summarized in a study entitled the development of learning media in a gas-fired gas stove to increase students' curiosity in applied physics subjects. This study uses a media development research method known as Research and Development (R&D). From the research carried out, the following data were obtained: the results of media validation obtained very good categories, and validation test by media experts found very good category. In the curiosity test, which was initially limited to active students, the scores were very good. The results of the initial average curiosity test for the field test were obtained in the low category, and after the use of the media was tested again, and the average score was obtained in the very good category. It can be concluded that the use of an oil-fired gas steam stove in the form of a Pertamax stove as a learning medium can increase students' curiosity about learning applied physics material.
Pengembangan Potensi Ekstrak Belut (Monopterus albus) dalam Menangkal Radikal Bebas
Authors: Rahman Havizur , Sari Putri Maya , Fitrianingsih Fitrianingsih , Kurniati Ai , Kurniawati Fitri 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui aktifitas antioksidan dari ekstrak belut (Monopterus albus) yang hidup di perairan provinsi jambi. Radikal bebas cenderung menimbulkan reaksi berantai yang apabila terjadi di dalam tubuh akan dapat menimbulkan kerusakan sel yang berlanjut dan terus menerus terutama pada penyakit kronis seperti diabetes, hipertensi dan hiperkolesterol. Pencegahan dapat dilakukan dengan memberikan seyawa antioksidan, salah satunya asam amino. Di dalam al-Quran disebutkan bahwa bangkai yang halal untuk dimakan adalah ikan dan belalang. Belut merupakan salah satu jenis ikan yang memiliki kandungan albumin yang tinggi. Sampel daging belut yang telah difillet dan dipisahkan dari kepalanya, dipotong kecil-kecil dengan ukuran 1,5 cm2 dan dibalut dengan kain tipis dalam sebuah mangkuk, lalu dikukus, dipress, dan disentrifus. diambil fase air dan minyak dan dibuang pengotornya dengan cara disaring, lalu dikeringkan menggunakan freeze drying sehingga diperoleh ekstrak belut dalam bentuk serbuk. Metode yang digunakan pada penelitian ini adalah Radical Scavenging method menggunakan senyawa kimia DPPH (2,2- difenil-1-pikrilhidrazil). Dari hasil penelitian ditemukan bahwa nilai IC50 ekstrak belut sebesar 29,0816 ppm. Ekstrak belut memiliki potensi menangkal radikal bebas dengan aktifitas kuat. Kata Kunci: Ektstrak Belut, Monopterus albus, Penangkal Radikal Bebas This study aims to determine the antioxidant activity of eel (Monopterus albus) extracts that live in the waters of the province of Jambi. Free radicals tend to cause chain reactions that occur in the body and will cause ongoing and continuous cell damage, especially in chronic diseases such as diabetes, hypertension and hypercholesterolemia. Prevention can be done by providing antioxidants, one of which is amino acids. In the Koran, it is stated that the carcasses that are lawful to eat are fish and grasshoppers. Eel is a type of fish that has a high albumin content. The eel meat sample that has been filled and given from its head, is cut into small pieces with a size of 1.5 cm2 and wrapped in a thin cloth in a container, then steamed, pressed, and centrifuged. the air and oil phases are taken and the impurities are removed by filtering, then they are dried using freeze drying in order to obtain the eel extract in powder form. The method used in this study is the Radical Scavenging Method using the chemical compound DPPH (2,2- diphenyl-1-pikrilhidrazil). From the research results it was found that the IC50 value of eel extract was 29.0816 ppm. Eel extract has the potential to ward off free radicals with strong activity.
Uji Aktivitas Antioksidan Menggunakan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Terhadap Ekstrak Etanol Kulit Buah Durian (Durio zibethinnus L.) dari Desa Alasmalang Kabupaten Banyumas
Authors: Prasetyo Eko , Kiromah Naelaz Zukhruf Wakhidatul , Rahayu Titi Pudji 
Published: March 2021

Kulit durian merupakan bagian tanaman yang pernah diteliti sebelumnya dan mempunyai aktivitas farmakologi sebagai antioksidan. Kulit durian mengandung metabolit sekunder yaitu flavonoid, tanin dan alkaloid. Kulit durian diekstrak menggunakan pelarut etanol 70% dengan metode sokletasi. Pengujian aktivitas antioksidan menggunakan metode pengukuran penangkapan radikal bebas oleh 1,1-difenil-2-pikrilhidrazil (DPPH). Vitamin C digunakan sebagai kontrol positif dengan nilai IC50 5,63 ppm dan ekstrak etanol sebesar 204,33 ppm. Penelitian ini menunjukkan bahwa ekstrak etanol kulit durian tidak memiliki aktivitas antioksidan menggunakan metode DPPH. Kata Kunci: Durian, Sokletasi, DPPH (2,2-difenil-1-pikrilhidrazil), antioksidan, IC50 Durian fruit peels (Durion zibethinus Murr.) have been studied previously and reported to have phramacological activity that has the potential to be antioxidant. The durian fruits peels, contained secondary metabolite, namely flavonoids, tannin and alkaloid. Durian fruit peels (Durion zibethinus Murr.) were extracted with ethanol 70% with soxletation method. The antioxidant activity of extracts were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. Vitamin C was used as standard with IC50 5,63 ppm and the ethanol eztracts showed IC50 204,33 ppm. This study provided that Durian fruit peels (Durion zibethinus Murr.) cannot inhibit free radical usimg the DPPH method.
Preclinical Evaluation and Pilot Clinical Study of 18F-AlF-labeled FAPI-Tracers for PET&nbsp;Imaging of Cancer Associated Fibroblasts
Authors: Hu Kongzhen , Li Junqi , Wang Lijuan , Huang Yong , Li Li , Ye Shimin , Han Yanjiang , Huang Shun , Wu Hubing , Su Jin , Tang Ganghua 
Published: March 2021

Abstract
Background The recent development of many different types of radiotracers that target the fibroblast activation protein (FAP) has been promising for tumor diagnosis. Here, we set out to develop 18F-labeled FAP tracers for cancer-associated fibroblast imaging and evaluated the potential of these tracers for clinical application. Methods The non-radioactive reference compounds and labeling precursors were synthesized using organic chemistry and the binding affinities were identified using surface plasmon resonance. Both radioligands (18F-P-FAPI and 18F-FAPI-42) were produced in an automated manner via complexation of Al18F. For in vitro characterization of 18F-P-FAPI and 18F-FAPI-42, we conducted studies to determine the partition coefficients, stability, cellular uptake, internalization, and efflux. In vivo biodistribution studies and microPET imaging of 18F-P-FAPI and 18F-FAPI-42, in comparison to 68Ga-FAPI-04, were conducted on the A549-FAP tumor bearing mice. Finally, one nasopharyngeal cancer patient underwent whole-body PET/CT after being injected with 18F-P-FAPI. Results Both 18F-P-FAPI and 18F-FAPI-42 were successful prepared with high specificity, rapid internalization, and potent affinity binding toward FAP. Compared to 18F-FAPI-42, 18F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in vivo. Furthermore, in vivo studies of 18F-P-FAPI in the A549-FAP tumor model indicated a higher tumor uptake than 18F-FAPI-42 and 68Ga-FAPI-04. An initial diagnostic application in patient with nasopharyngeal cancer, 18F-P-FAPI and 18F-FDG PET/CT showed comparable results for both primary tumors and lymph node metastases. Conclusion The radiofluorinated FAP-ligands demonstrated promising characteristics in their preclinical evaluation, and the feasibility of cancer-associated fibroblasts imaging was demonstrated using PET studies.
Preliminary Report of De Novo Adipogenesis Using Novel Bioabsorbable Implants and Image Evaluation Using A Porcine Model
Authors: Ogino Shuichi , Yamada Atsushi , Kambe Yusuke , Nakano Takashi , Lee Sunghee , Sakamoto Michiharu , Kato Yuki , Okumura Saki , Okano Junko , Yamauchi Koji , Suzuki Yoshihisa , Yamaoka Tetsuji , Morimoto Naoki 
Published: March 2021

Abstract
Our bioabsorbable poly-L-lactic acid (PLLA) mesh implants containing collagen sponge is replaced with adipose tissue after implantation and is an innovative method for breast reconstruction. We investigated the formation of adipose tissue in a porcine model and evaluated the process via multimodal images in this preliminary study using an implant aggregate to generate the larger adipose tissue. The implant aggregate consists of PLLA mesh implants containing collagen sponge and a poly-glycolic acid woven bag covering them. We inserted the implant aggregates under the porcine mammary glands. Magnetic resonance imaging (MRI), ultrasonography (USG), and 3D surface imaging, and histological evaluations were performed to evaluate the formation of adipose tissue over time. The volume of the implant aggregate and the formed adipose tissue inside the implant aggregate could be evaluated over time via MRI. The space within the implant aggregate was not confirmed on USG due to the acoustic shadow of the PLLA threads. The change in volume was not confirmed precisely using 3D surface imaging. Histologically, the newly-formed adipose tissue was confirmed on the skin side. This implant aggregate has the ability to regenerate adipose tissue, and MRI is an appropriate method for the evaluation of the formation of adipose tissue.
Application of the Proximal Isovelocity Surface Area Method for Estimation of the Effective Orifice Area in Aortic Stenosis
Authors: Nakabachi Masahiro , Iwano Hiroyuki , Murayama Michito , Nishino Hisao , Yokoyama Shinobu , Tsujinaga Shingo , Chiba Yasuyuki , Ishizaka Suguru , Motoi Ko , Okada Kazunori , Kaga Sanae , Nishida Mutsumi , Teshima Takanori , Anzai Toshihisa 
Published: March 2021

Abstract
Purpose: Because existence of high flow velocity at the left ventricular outflow tract (LVOT) potentially causes an overestimation of effective orifice area (EOA) by continuity equation in aortic stenosis (AS), we tested the proximal isovelocity surface area (PISA) method as an alternative tool for AS.Methods: EOA was calculated using the continuity equation (EOACont) and PISA method (EOAPISA), respectively, in 114 patients with at least moderate AS. The geometric orifice area (GOA) was also measured in 51 patients who also underwent three-dimensional transesophageal echocardiography (TEE). Patients were divided into two groups according to the median LVOT flow velocity.Results: Feasibility of EOAPISA was 95% in the 114 patients. While there was a strong correlation between EOACont and EOAPISA, EOACont was greater than EOAPISA especially in patients with high LVOT velocity. In TOE cohort, both EOACont and EOAPISA similarly correlated with GOA. However, a fixed bias, which is supposed to exist in AS, was observed only between EOAPISA and GOA with smaller EOAPISA than GOA. The difference between EOACont and GOA was significantly greater with a larger EOACont relative to GOA in patients with high LVOT velocity than in those without (0.16±0.25 vs -0.07±0.10 cm2, P<0.001). In contrast, the difference between EOAPISA and GOA was consistent in both groups (-0.07±0.12 vs -0.07±0.15 cm2, P = 0.936). Conclusion: The PISA method was applied to estimate EOA of AS. EOAPISA could be an alternative parameter for AS severity grading in patients with high LVOT velocity in whom EOACont would overestimate the orifice area.
NEWS2 score in the practice of infectious diseases hospital in COVID-19 patients. Implementation and results
Authors: Popova К. N. , Zhukov A. A. , Zykina I. L. , Troschanskiy D. V. , Tyurin I. N. , Protsenko D. N. 
Published: March 2021

Amidst the new COVID-19 pandemic, there is a need for a reliable medical tool to monitor patients’ vital conditions with clinical information continuity. This tool is essential for timely detection of the risk of the patient’s clinical state deterioration throughout all the stages of medical assistance. The objective is to assess results of the NEWS2 score implementation at the in-patient stage of medical care.Methods. 183,732 scores of the NEWS2 score in 10,290 hospitalized patients were analyzed. All the assessed results of the NEWS2 score were retrospectively analyzed. The NEWS2 score results were added to the United Medical Information and Analytical System of Moscow (EMIAS) database through the NEWS2 mobile application. The researchers analyzed the descriptive statistics of the score; the prognostic significance of NEWS2 in the prediction of the disease outcome was assessed as well as the accuracy of the used methods. Results. As the result of the research, deviations from standard methods in the application of the NEWS2 score were outlined, which allowed the researchers to develop the corrective measures. The received data confirmed that interval assessment by the NEWS2 score and the trend analysis were important when making clinical and organizational decisions. Specific parameters of the score use during the COVID-19 pandemic were outlined, which helped to adjust the in-hospital procedures for clinical decision-making process, routing, and the continuity of all stages of medical assistance was established. Conclusion. The use of the NEWS2 score in medical practice makes it possible to predict the risks of clinical deterioration in the patient's condition, conduct bedside monitoring of therapy effectiveness, and optimize in-hospital routing. However, to ensure the validity of the score, it is necessary to plan activities for the personnel training and motivation, as well as to monitor careful adherence to the protocol.
Implementasi Corporate Social Responsibility pada Hotel Puri Santrian Sanur Bali
Authors: Nadiawati Ni Made Yuni Sri , Budiasih I G. A. N. 
Published: March 2021

The implementation of CSR is considered to benefit the hospitality industry, which will impact on increasing visitor loyalty. One of the CSR awards in Bali is Tri Hita Karana (THK Award). Puri Santrian, one of the participating hotels, is a participant in the Tri Hita Karana Award. The purpose of this research is to know the implementation of CSR in Puri Santrian Hotel. This method of research uses qualitative methods. The location of this research is Hotel Puri Santrian. The informant chosen is HRD staff, Engineering staff, Accounting staff. The interview shows the Santrian Palace has implemented CSR based on the well-established philosophy of Tri Hita Karana. However, in the part of the given assistance can be more varied.
Keywords: Corporate Social Responsibility, Tri Hita Karana, Implementation Of CSR Practices.
Diskriminasi Perempuan dalam Pupulan Cerpen Tatu Anak Luh Pendekatan Feminisme
Authors: Widiantara I Wayan , Suteja I Wayan , Puspawati Luh Putu 
Published: March 2021

This study is entitled "Discrimination of Women in Pupulan Tatu Anak Luh Short Stories Feminsime Approach" by discussing three short stories namely Tatu Anak Luh short stories, Mejalan Tanpa Batis and Mepasung Ulian Warisan with the feminsime approach. Research on Pupil Tatu Anak Luh Short Story discusses the analysis of the structure and discrimination of women in the form of violence. This analysis aims to reveal the structure and violence contained in the short story of Tatu Anak Luh.
This research uses structural theory and feminism theory. The methods and techniques used in this study were divided into three stages, namely: (1) methods and data collection techniques using the listening method assisted with translation and note-taking techniques. (2) data analysis methods and techniques using qualitative methods and analytic descriptive techniques. (3) methods and techniques for presenting the results of data analysis using informal methods assisted with deductive-inductive techniques. The results obtained from this study, namely the narrative structure consisting of incidents, plot, character and characterization, setting, theme, and mandate. In addition, this study also revealed female discrimination, in the form of verbal violence, physical violence and mental or psychological violence.
Eccrine Poromatosis Following Lymphoma Treatment: A Case Report and Literature Review
Authors: Alkul Suzanne , Graubard Rachel , Wasko Carina 
Published: March 2021

Eccrine poromas are benign tumors that arise from the eccrine sweat ducts, commonly presenting as solitary lesions. Eccrine poromatosis, the sudden eruption of multiple eccrine poromas, is a rare phenomenon that generally occurs in immunosuppressed patients at any time after receiving treatment for malignancy. We report a case of eccrine poromatosis in a 79-year-old male patient with a previous history of recurrent T-cell lymphoma. Over the course of his disease, he was treated with polychemotherapy, radiation, and a definitive bone marrow transplant. The patient presented to the dermatology clinic 18 years after his initial diagnosis with a new onset of pruritic papules on the neck and chest. Histologic evaluation revealed all lesions to be eccrine poromas. This is the longest reported time interval between initial diagnosis of a primary malignancy and development of eccrine poromatosis. There is no evidence at this time to suggest that appearance of such lesions is indicative of cancer recurrence; therefore, there is no indication for further oncologic evaluation.
Knowledge of Postnatal Care among Confinement Ladies in Malaysia during COVID-19 Pandemic: A Pilot Study
Authors: NA Mohd Jidin , Mohamad M - , WNS Wan Mohd Kamaluddin , KH Abd Aziz , NA Jamani 
Published: March 2021

Objective: This study aims to evaluate the knowledge of postnatal care among confinement ladies in Malaysia and assess the effectiveness of an intervention workshop.Methods: A quasi-experimental study was conducted among 65 confinement ladies residing in East Coast Malaysia. Among them, 36 ladies were purposely selected to participate in a workshop, while 29 ladies were selected using a snowball sampling method to be in the control group. A validated Malay translation of Knowledge on Postnatal Care for Mothers and Care of the Newborn Questionnaire was used. Data were analysed using IBM SPSS Statistics (Version 25). Multiple logistic regression was employed to determine factors associated with baseline knowledge. Repeated measure ANCOVA was used to measure the effectiveness of the intervention workshop.Results: Overall, the mean (SD) age of the respondents was 46.23 (8.49) with mean (SD) number of children of 4.0 (2.0) and working experience as confinement ladies of 36.0 months (20.24). Majority (77.1%) were married, from B40 group (91.4%) and received at least secondary education (77.1%). Confinement ladies who received secondary and tertiary education were found to have higher knowledge scores compared to those with primary education (p=0.026 and p=0.049 respectively). There was a significant increase in knowledge of postnatal care scores in those attending the postnatal care workshop (p <0.001)Conclusion: Education level plays an important role in determining the level of knowledge of a confinement lady. The workshop conducted was effective in improving the postnatal care knowledge among confinement ladies. Hence, more interventional programs should be held in the future.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S22