bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter‐Calibrated Measurements of Intense Whistlers by Arase and Van Allen Probes
Authors: Santolík O. , Miyoshi Y. , Kolmašová I. , Matsuda S. , Hospodarsky G. B. , Hartley D. P. , Kasahara Y. , Kojima H. , Matsuoka A. , Shinohara I. , Kurth W. S. , Kletzing C. A. 
Published: September 2021

AbstractMeasurements of electromagnetic waves in space plasmas are an important tool for our understanding of physical processes in this environment. Inter‐calibration of data from different spacecraft missions is necessary for combining their measurements in empirical models or case studies. We show results collected during a close conjunction of the Van Allen Probes and Arase spacecraft. The inter‐calibration is based on a fortuitous case of common observations of strong whistlers at frequencies between a few hundred hertz and 10 kHz, which are generated by the same lightning strokes and which propagate along very similar paths to the two spacecraft. Measured amplitudes of the magnetic field fluctuations are the same within ∼14% precision of our analysis, corresponding to 1.2 dB. Currently, archived electric field measurements show twice larger amplitudes on Arase compared to Van Allen Probes but they start to match within ∼33% precision (2.5 dB) once the newest results on the interface of the antennas to the surrounding plasma are included in the calibration procedures. Ray tracing simulations help us to build a consistent scenario of wave propagation to both spacecraft reflected by a successful inter‐calibration of the polarization and propagation parameters obtained from multicomponent measurements. We succeed in linking the spacecraft observations to localizations of lightning return strokes by two different ground‐based networks which independently verify the correctness of the Universal Time tags of waveform measurements by both spacecraft missions, with an uncertainty better than 10 ms.
Weakening Mechanisms in a Basalt‐Hosted Subduction Megathrust Fault Segment, Southern Alaska
Authors: Braden Zoe , Behr Whitney M. 
Published: September 2021

AbstractBasaltic and gabbroic rocks that define the seafloor have been suggested to act as sources of rheological heterogeneity during subduction, with the capacity to enhance or dampen seismicity. Despite this, relatively little is known from the rock record regarding the progression and conditions of mafic oceanic crust deformation during subduction, particularly in the shallow megathrust region of the seismogenic zone. We describe subduction‐related deformation structures and characterize deformation conditions from an exhumed, basalt‐hosted megathrust in the Chugach accretionary complex of south‐central Alaska. Rocks in the Chugach preserve a record of seafloor mineralogical changes from pre‐subduction, hydrothermal circulation that produced sheet silicates with a lower frictional strength than intact basalt. Pre‐subduction alteration also served to introduce hydrous phases that can expel water during deformation and raise the pore fluid pressure. Once strain localized within basalts onto a megathrust fault plane at lithostatic pore fluid pressures, the basalt weakened further through a combination of cataclasis, dilatational shear fracturing, and slip on chlorite‐rich shear bands. This process occurred in a narrower fault zone, and at higher maximum differential stress and greater pore fluid pressure fluctuations than recorded in some sediment‐hosted megathrusts at similar pressure and temperature conditions. Our data indicate that when the lower plate contains basalt bathymetric features, basalt dismembers during subduction into a chlorite‐rich fault gouge that surrounds lenses or slices of intact, less‐altered basalt.
A Hemispheric and Seasonal Comparison of Tropospheric to Mesospheric Gravity‐Wave Propagation
Authors: Alexandre D. , Thurairajah B. , England S. L. , Cullens C. Y. 
Published: September 2021

AbstractDeep convection from monsoons has been shown to be a major tropospheric source of gravity waves (GWs) in the summer hemisphere. These GWs can propagate up to the upper mesosphere, either vertically (over the same latitude) or obliquely (latitudinal propagation away from their source), where they dissipate and release their momentum. These waves play an important role in the global dynamical structure of the middle atmosphere. Understanding their hemispheric and seasonal variations could improve the GW parameterization schemes in present global models. To this end, this paper reports on a GW ray‐tracing analysis using the GROGRAT model to simulate the propagation of GWs from the monsoon regions in the northern and the southern hemispheres during both the summer and the winter seasons. The 20 simulations show the southern hemisphere to be more conducive to both the vertical and the oblique propagation of mesospheric GWs compared to the northern hemisphere, regardless of season. This is partially due to a stronger GW filtering in the northern hemisphere near the tropopause where a third of the waves have been vertically reflected. We also show that an increase in the horizontal wavelength increases not only the latitudinal component but also the longitudinal component of the oblique propagation of GWs. The broad spectrum of waves with different horizontal wavelengths and horizontal phase speeds used in this study highlights the existence of an upper limit in the horizontal wavelength of GWs that can reach the upper mesosphere.
Complex High‐ and Low‐Flow Networks Differ in Their Spatial Correlation Characteristics, Drivers, and Changes
Authors: Brunner Manuela I. , Gilleland Eric 
Published: September 2021

AbstractHydrologic extremes such as floods and droughts are often spatially related, which increases management challenges and potential impacts. However, these spatial relationships in high and low flows are often overlooked in risk assessments and we know little about their differences and origins. Here, we ask how spatial relationships of both types of hydrologic extremes and their potential hydro‐meteorological drivers differ and vary by season. We propose lagged upper‐ and lower‐tail correlation as a measure of extremal dependence for temporally ordered events to build complex networks of high and low flows. We compare complex networks of overall, low and high flows, determine hydro‐meteorological drivers of these networks, and map past changes in spatial relationships using a large‐sample data set in Central Europe. Our network comparison shows that low flows are correlated more strongly and over longer distances than high flows and high‐ and low‐flow networks are strongest in spring and weakest in summer. Our driver analysis shows that high‐flow dependence is most strongly governed by precipitation in winter and evapotranspiration in summer while low‐flow dependence is most strongly governed by snowmelt in winter and evapotranspiration in fall. Finally, our change analysis shows that changes in connectedness (i.e., the number of catchments a catchments shows strong flow correlations with) vary spatially and are mostly positive for high flows. We conclude that spatial flow correlations are considerable for both high and particularly low flows as a result of a combination of spatially related hydro‐meteorological drivers whose importance varies by extreme type and season.
Simulating Core Floods in Heterogeneous Sandstone and Carbonate Rocks
Authors: Wenck Nele , Jackson Samuel J. , Manoorkar Sojwal , Muggeridge Ann , Krevor Samuel 
Published: September 2021

AbstractThe characterization of multiphase flow properties is essential for predicting large‐scale fluid behavior in the subsurface. Insufficient representation of small‐scale heterogeneities has been identified as a major gap in conventional reservoir simulation workflows. We systematically evaluated the workflow developed by Jackson et al. (2018), https://doi.org/10.1029/2017wr022282 for use on rocks with complex porosity and capillary heterogeneities. The workflow characterizes capillary heterogeneity at the millimeter scale. The method is a numerical history match of a coreflood experiment with the 3D saturation distribution as a matching target and the capillary pressure characteristics as a fitting parameter. Coreflood experimental datasets of five rock cores with distinct heterogeneities were analyzed: two sandstones and three carbonates. The sandstones exhibit laminar heterogeneities. The carbonates have isotropic heterogeneities at a range of length scales. We found that the success of the workflow is primarily governed by the extent to which heterogeneous structures are resolved in the X‐ray imagery. The performance of the characterization workflow systematically improved with increasing characteristic length scales of heterogeneities. Using the validated models, we investigated the flow rate dependency of the upscaled relative permeability. The findings showed that the isotropic heterogeneity in the carbonate sample resulted in non‐monotonic behavior; initially the relative permeability increased, and then subsequently decreased with increasing flow rate. The work underscores the importance of capturing small‐scale heterogeneities in characterizing subsurface fluid flows, as well as the challenges in doing so.
Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
Authors: Hou Bao-Long , Wong Jonathan J. , Lv Na , Wang Yong-Qiang , Houk K. N. , Li Chuang-Chuang 
Published: September 2021

AbstractBridged medium-sized bicyclo[m.n.2] ring systems are common in natural products and potent pharmaceuticals, and pose a great synthetic challenge. Chemistry for making bicyclo[m.n.2] ring systems remains underdeveloped. Currently, there are no general reactions available for the single-step synthesis of various bridged bicyclo[m.n.2] ring systems from acyclic precursors. Here, we report an unusual type II intramolecular (3+2) dipolar cycloaddition strategy for the syntheses of various bridged bicyclo[m.n.2] ring systems. This rhodium-catalysed cascade reaction provides a relatively general strategy for the direct and efficient regioselective and diastereoselective synthesis of highly functionalized and synthetically challenging bridged medium-sized polycyclic systems. Asymmetric total synthesis of nakafuran-8 was accomplished using this method as a key step. Quantum mechanical calculations demonstrate the mechanism of this transformation and the origins of its multiple selectivities. This reaction will inspire the design of the strategies to make complex bioactive molecules with bridged medium-sized polycyclic systems.
Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
Authors: Liu Yingjie , Zhang Peiyuan , Wu Qiuyao , Fang Houqin , Wang Yuan , Xiao Yansen , Cong Min , Wang Tingting , He Yunfei , Ma Chengxin , Tian Pu , Liang Yajun , Qin Lun-Xiu , Yang Qingcheng , Yang Qifeng , Liao Lujian , Hu Guohong 
Published: September 2021

AbstractDisseminated tumor cells often fall into a long term of dormant stage, characterized by decreased proliferation but sustained survival, in distant organs before awakening for metastatic growth. However, the regulatory mechanism of metastatic dormancy and awakening is largely unknown. Here, we show that the epithelial-like and mesenchymal-like subpopulations of breast cancer stem-like cells (BCSCs) demonstrate different levels of dormancy and tumorigenicity in lungs. The long non-coding RNA (lncRNA) NR2F1-AS1 (NAS1) is up-regulated in the dormant mesenchymal-like BCSCs, and functionally promotes tumor dissemination but reduces proliferation in lungs. Mechanistically, NAS1 binds to NR2F1 mRNA and recruits the RNA-binding protein PTBP1 to promote internal ribosome entry site (IRES)-mediated NR2F1 translation, thus leading to suppression of ΔNp63 transcription by NR2F1. Furthermore, ΔNp63 downregulatio results in epithelial-mesenchymal transition, reduced tumorigenicity and enhanced dormancy of cancer cells in lungs. Overall, the study links BCSC plasticity with metastatic dormancy, and reveals the lncRNA as an important regulator of both processes.
Neural evidence for lexical parafoveal processing
Authors: Pan Yali , Frisson Steven , Jensen Ole 
Published: September 2021

AbstractIn spite of the reduced visual acuity, parafoveal information plays an important role in natural reading. However, competing models on reading disagree on whether words are previewed parafoveally at the lexical level. We find neural evidence for lexical parafoveal processing by combining a rapid invisible frequency tagging (RIFT) approach with magnetoencephalography (MEG) and eye-tracking. In a silent reading task, target words are tagged (flickered) subliminally at 60 Hz. The tagging responses measured when fixating on the pre-target word reflect parafoveal processing of the target word. We observe stronger tagging responses during pre-target fixations when followed by low compared with high lexical frequency targets. Moreover, this lexical parafoveal processing is associated with individual reading speed. Our findings suggest that reading unfolds in the fovea and parafovea simultaneously to support fluent reading.
Luminescent lanthanide nanoparticle-based imaging enables ultra-sensitive, quantitative and multiplexed in vitro lateral flow immunoassays
Authors: Mousseau F. , Féraudet Tarisse C. , Simon S. , Gacoin T. , Alexandrou A. , Bouzigues C. I. 
Published: September 2021

We developed a portable, fast, highly sensitive and quantitative in vitro assay for on-site biomolecule detection by combining the remarkable optical properties of new lanthanide-doped nanoparticle probes with a simple reader coupled to a smartphone.
Reliability and Accuracy of Expert Auditory-Perceptual Evaluation of Voice via Telepractice Platforms
Authors: Dahl Kimberly L. , Weerathunge Hasini R. , Buckley Daniel P. , Dolling Anton S. , Díaz-Cádiz Manuel , Tracy Lauren F. , Stepp Cara E. 
Published: September 2021

Purpose
This study assessed the reliability and accuracy of auditory-perceptual voice evaluations by experienced clinicians via telepractice platforms.

Method
Voice samples from 20 individuals were recorded after transmission via telepractice platforms. Twenty experienced clinicians (10 speech-language pathologists, 10 laryngologists) evaluated the samples for dysphonia percepts (overall severity, roughness, breathiness, and strain) using a modified Consensus Auditory-Perceptual Evaluation of Voice. Reliability was calculated as the mean of squared differences between repeated ratings (intrarater agreement), and between individual and group mean ratings (interrater agreement). Repeated measures analyses of variance were constructed to measure effects of transmission condition (e.g., original recording, WebEx, Zoom), dysphonia percept, and their interaction on intrarater agreement, interrater agreement, and average ratings. Significant effects were evaluated with post hoc Tukey's tests.

Results
There were significant effects of transmission condition, percept, and their interaction on average ratings, and a significant effect of percept on interrater agreement. Post hoc testing revealed statistically, but not clinically, significant differences in average roughness ratings across transmission conditions, and significant differences in interrater agreement for several percepts. Overall severity had the highest agreement and strain had the lowest.

Conclusion
Telepractice transmission does not substantially reduce reliability or accuracy of auditory-perceptual voice evaluations by experienced clinicians.
Implementing adaptive risk management for synthetic biology: Lessons from iGEM's safety and security programme
Authors: Millett Piers , Alexanian Tessa 
Published: September 2021

AbstractSynthetic biology offers exciting possibilities to deal with local and global challenges over the coming decades. As we make greater use of biological engineering, it will be increasingly important to balance potential risks and benefits. The rate, scale, and diffusion of relevant capabilities will make this challenging. There will be a growing need for flexible risk management approaches, which can be rapidly adapted as technology and societal needs change. This study details efforts by the International Genetically Engineered Machine (iGEM) competition in creating and implementing an adaptive risk management approach. It concludes with key lessons and challenges: working with hazardous materials, such as dangerous pathogens, toxins and chemicals; managing risks to plants, animals and the environment; use of samples from people, animals, and the environment; improving the hazards identified; variations in risk perception and tolerance; variation in terminology that complicates interpretation of risk management plans; and connections with broader societal or ethical questions, such as animal use, gender and sexuality, or benefit sharing.
Prior‐guided multiscale network for single‐image dehazing
Authors: Wang Nian , Cui Zhigao , Su Yanzhao , He Chuan , Lan Yunwei , Li Aihua 
Published: September 2021

AbstractSingle‐image dehazing is an important problem because it is a key prerequisite for most high‐level computer vision tasks. Traditional prior‐based methods adopt priors generated from clear images to restrain the atmospheric scattering model and then recover haze‐free images. However, these prior‐based methods always encounter over‐enhancement, such as halos and colour distortion. To solve this problem, many works use a convolutional neural network to retrieve original images. However, without priors as guidance, these learning‐based methods dehaze effectively in synthetic datasets but perform poorly in real scenes. Hence, in this paper, we propose a prior‐guided multiscale network for single‐image dehazing named PGMNet. Specifically, prior‐based methods are adopted to acquire dehazed images of the training dataset in advance and then send these dehazed images to a parameter‐shared encoder to form multiscale features. During the decoding process, these multiscale features are adopted to guide the prior‐guided multiscale network to recover more image details. Moreover, considering that these prior‐based dehazed images usually contain some over‐enhanced regions, a spatial attention guided feature aggregation module and squeeze‐and‐excitation module are adopted to alleviate colour distortion. The proposed PGMNet takes the advantage of prior‐based methods in real haze removal and provides superior performance compared with the state‐of‐the‐art methods on both synthetic and real‐world datasets.
S1-Leitlinie Post-COVID/Long-COVID
Authors: Koczulla Andreas Rembert , Ankermann Tobias , Behrends Uta , Berlit Peter , Böing Sebastian , Brinkmann Folke , Franke Christian , Glöckl Rainer , Gogoll Christian , Hummel Thomas , Kronsbein Juliane , Maibaum Thomas , Peters Eva M. J. , Pfeifer Michael , Platz Thomas , Pletz Matthias , Pongratz Georg , Powitz Frank , Rabe Klaus F. , Scheibenbogen Carmen , Stallmach Andreas , Stegbauer Michael , Wagner Hans Otto , Waller Christiane , Wirtz Hubert , Zeiher Andreas , Zwick Ralf Harun 
Published: September 2021

ZusammenfassungDie Deutsche Gesellschaft für Pneumologie hat die AWMFS1-Leitlinie Post-COVID/Long-COVID initiiert. In einem breiten interdisziplinären Ansatz wurde diese S1-Leitlinie basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt die aktuellen Post-COVID/Long-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen und konsentierten Einführung wurde ein fachspezifischer Zugang gewählt, der den aktuellen Wissensstand zusammenfasst.Die Leitlinie hat einen expilzit praktischen Anspruch und wird basierend auf dem aktuellen Wissenszugewinn vom Autorenteam stetig weiterentwickelt und adaptiert.
The Impact of COVID-19 Pandemic on Cancer Care in a Tertiary Care Facility
Authors: K. Pradeep Kumar Reddy , Elagandula Jyosthna , Patel Shivani , Patidar Rajesh , Asati Vikas , Shrivastav Shiv Prasad , Elhence Aditya , Sharma Runu , Ankit B. S. , Chitalkar Prakash G. 
Published: September 2021

AbstractBackground Coronavirus disease 2019 (COVID-19) pandemic had an overwhelming impact on health care worldwide. Cancer patients represent a subgroup that is vulnerable and is under high risk. It is, therefore, necessary to analyze factors that predict outcomes in these patients so that they can be triaged accordingly to mitigate the effects of COVID-19 on cancer management. To date, the impact of COVID-19 on cancer patients remain largely unknown.Methods Data of 291 cancer patients undergoing active treatment from March 23 to August 15, 2020 were retrospectively reviewed; the incidence, demographic and clinical characteristics, treatment, and outcomes of cancer patients infected by COVID-19 were included in the analysis.Discussion During the index period (March 23–August 15, 2020), 4,494 confirmed cases of COVID-19 were admitted at our institute. In the department of medical oncology out of 578 patients presented to outpatient department, 291 patients were admitted for active treatment. Considering the cancer patients, infection rate was 7.9% (23/291) and mortality 13% (3/23). Median age was 40 years and the majority of patients were male (60%). The most common cancer type was acute lymphoblastic leukemia presented at various stages of treatment. Twenty patients (86.9%) were discharged after full clinical recovery and negative real-time polymerase chain reaction on a nasopharyngeal swab. Anticancer treatment was modified according to the type of cancer under intensive surveillance.Conclusion Although mortality rate in COVID-19 cancer patients is elevated, our results support the feasibility and safety of continuing anticancer treatment during pandemic by endorsing consistent preventive measures, but however should be modified based on the type and prognosis of cancer.
Prehabilitation and Nutrition in Hernia Surgery
Authors: Cadena-Semanate Ramiro , Jara Ramon Diaz , Guerron Alfredo D. , Yoo Jin 
Published: September 2021

AbstractVentral hernia repair (VHR) is among the most frequently performed surgical procedures in the United States. Despite advancements in surgical technique, a significant number of VHR patients experience postoperative complications and hernia recurrence. A key strategy to reduce VHR morbidity is patient optimization before surgery with prehabilitation protocols. Prehabilitation aims to improve patients' functional status with physical conditioning, nutritional intervention, and psychological support. In other surgical disciplines, prompt preoperative action has proven to significantly reduce the negative influence of modifiable comorbidities and accelerate recovery. In this article, we review the literature to assess the applicability and benefits of prehabilitation in elective VHR cases. A review of the available evidence identified obesity, hyperglycemia, and smoking as significant modifiable risk factors that negatively affect VHR outcomes. Prehabilitation has the potential to mitigate and control these comorbidities. Physical conditioning with aerobic, resistance, and inspiratory muscle training is beneficial. Nutritional intervention to control diabetes and in severely malnourished patients is especially important in patients undergoing concomitant gastrointestinal procedures with VHR. Reasonable targets for prehabilitation protocols in elective VHR include a body mass index of 35 kg/m2, HbA1C of 6.5% and tobacco abstinence for at least 4 weeks. Prophylactic measures to minimize the rates of incisional hernia after primary laparotomy repairs include mesh reinforcement and a suture to wound length ratio of at least 4:1.