bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial
Authors: Burrows Kaiping , Figueroa-Hall Leandra K. , Kuplicki Rayus , Stewart Jennifer L. , Alarbi Ahlam M. , Ramesh Rajagopal , Savitz Jonathan B. , Teague T. Kent , Risbrough Victoria B. , Paulus Martin P. 
Published: August 2021

Abstract
This double-blind, randomized, repeated measures study evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females,10 males) completed a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from plasma and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. Our findings indicate that miR-27b could be an important messaging molecule altered by anti-inflammatory drugs that relates to the processing of positive or negative valenced information.
Prevention of OUD: The HOME (Housing, Opportunities, Motivation and Engagement) Feasibility Study
Authors: Kelleher Kelly , Famelia Ruri , Yilmazer Tansel , Mallory Allen , Ford Jodi , Chavez Laura J. , Slesnicka Natasha 
Published: August 2021

Abstract
Young adults experiencing homelessness are at high risk of opioid and other substance use, poor mental health outcomes, exposure to trauma, and other risks. Providing access to stable housing has the potential to act as a powerful preventive intervention, but supportive housing programs have been studied most often among chronically homeless adults or adults with serious mental illness. The Housing First model, which does not precondition supportive housing on sobriety, has been shown to reduce drug use in homeless adults. In the present study, we piloted an adapted model of Housing First that was tailored to the needs of young adults (18–24 years) experiencing homelessness. Supportive services were added to the Housing First model and included youth-centered advocacy services, motivational interviewing, and HIV risk prevention services. This model was piloted in a single-arm study (n = 21) to assess the feasibility, acceptability, and initial efficacy of a Housing First model over a 6-month period. We use repeated measures ANOVA to test for changes in alcohol and drug use (percent days of use; alcohol or drug use consequences), housing stability, social network support, and cognitive distortions over 6 months of follow-up. A total of 17 youth completed the study (85% retention) and a high proportion of youth were stably housed at 6-month follow-up. Participation in intervention services was high with an average of 13.57 sessions for advocacy, 1.33 for MI, and 0.76 for HIV prevention. Alcohol use did not change significantly over time. However, drug use, drug use consequences, and cognitive distortions, and the size of youths’ social networks that were drug using individuals decreased significantly. The Housing First model appeared to be feasible to deliver and youth engaged in the supportive intervention services. The study demonstrates the potential for an adapted Housing First model to be delivered to youth experiencing homelessness and may improve outcomes.
Effect of the finite speed of light in ionization of extended molecular systems
Authors: Ivanov I. A. , Kheifets Anatoli S. , Kim Kyung Taec 
Published: August 2021

Abstract
We study propagation effects due to the finite speed of light in ionization of extended molecular systems. We present a general quantitative theory of these effects and show under which conditions such effects should appear. The finite speed of light propagation effects are encoded in the non-dipole terms of the time-dependent Shrödinger equation and display themselves in the photoelectron momentum distribution projected on the molecular axis. Our numerical modeling for the H + 2 molecular ion and the Ne 2 dimer shows that the finite light propagation time from one atomic center to another can be accurately determined in a table top laser experiment which is much more readily affordable than the ground breaking synchrotron measurement by Grundmann et al [Science 370, 339 (2020)].
Health-related Quality of Life and Health Literacy in Patients With Systemic Mastocytosis and Mast Cell Activation Syndrome
Authors: Schmidt Tobias Jürgen , Sellin Julia , Molderings Gerhard J. , Conrad Rupert , Muecke Martin 
Published: August 2021

Abstract
Background: Systemic mastocytosis is a rare genetic disease characterized by aberrant proliferation and/or activation of mast cells, resulting in multi-organ, allergy-like symptoms. Mast cell activation syndrome (MCAS) is a clinically similar, but more prevalent disease with unclear etiology. In this study, the health-related quality of life (HRQOL) and health literacy of people suffering from SM and MCAS were assessed. Results: Two validated questionnaires (QLQ-C30 / QLQ-INFO25) from the European Organisation for Research and Treatment of Cancer (EORTC) were used to analyze HRQOL and level of information of SM and MCAS patients. In addition, a control group without any health issues was included. Data were analyzed by ANOVA and linear regression to detect significant differences. Questionnaire data from 66 patients with MCAS (83% female, mean 44 years), 32 patients with SM (78% female, mean 53 years) and 52 healthy participants (67% female, mean 48 years) resident in Germany were analyzed. HRQOL as measured by the Global health status was significantly worse in patients suffering from MCAS or SM compared to control group. Individuals with MCAS showed a slightly, but insignificantly lower score on Global health status, and a significantly lower score with respect to role function and fatigue. Patients with the rare disease SM felt significantly better informed on their disease compared to MCAS patients. Linear regression performed separately for both groups showed a direct influence of the level of information on patients' HRQOL.Conclusion: Overall, our study showed a significant negative impact on the HRQOL of both diseases, but only a small difference in quality of life and severity of symptoms between patients with MCAS and the supposedly more severe form, the rare disease SM. Our results demonstrate that the level of information patients receive impacts HRQOL, and that this is not only an issue in rare disease, but also diseases with unclear etiology and pathology. Our data shows that even slight improvements in the patient's level of information can have a positive effect on their quality of life, further highlighting the importance of gaining more knowledge on rare and incompletely understood diseases and communicating these insights to patients.
Prolonged Disorder of Consciousness — a New Concept in the Evaluation of Chronical Disorders of Consciousness in ICU Patients. A Multi-Disciplinary Concensus
Authors: Belkin Andrey A. , Suponeva N. A. , Voznyuk I. A. , Zaytsev O. S. , Zampolini M. , Ivanova N. E. , Ivanova G. E. , Kondratyeva E. A. , Lubnin A. Yu. , Petrova M. V. , Petrikov S. S. , Piradov M. A. , Popugaev K. A. , Pryanikov I. V. , Ryabinkina Yu. V. , Savin I. A. , Sergeev D. V. , Shchegolev A. V. , Zabolotskikh I. B. 
Published: August 2021

Chronic disorders of consciousness (DOC) develop after severe traumatic and non-traumatic brain damage and are characterized by the restoration of wakefulness in a patient after a coma without the recovery of consciousness. To optimize the diagnosis and treatment of patients with chronic DOC, a Russian working group on the problems of chronic DOC was organized, which included specialists in various areas, primarily anesthesiologists, critical care physicians and neurologists. While discussing the terminology of chronic DOC, the group identified that currently there is no definition for the state that falls into the period from the recovery of wakefulness and until 28 days after the brain damage when vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS) may be diagnosed. In the intensive care unit (ICU) setting, there is often no consultant to provide critical care physicians with the correct diagnosis of the latter clinical syndromes, and neurophysiological tests are not feasible either. Therefore, there is a need to create a set of simple, understandable and easily reproducible strategies for managing this category of patients in the ICU. Thus, the working group proposed the term “prolonged disorders of consciousness” to be used for the patients with the signs of VS/UWS or MCS syndromes during their stay in the ICU until 28 days after initial brain damage and/or until the correct differential diagnosis of a type of chronic DOC is made. With the introduction of prolonged disorders of consciousness definition, the regular ICU staff will better understand how to provide an optimal set of supportive therapy and early rehabilitation activities in the lack of specific diagnostics techniques and dedicated specialists. Allocation of this category of patients allows us to create an algorithm for their better diagnosis and management and ensures consistent and effective interdisciplinary care at various levels. On the one hand, this approach will help us allow to free up ICU beds that are in high demand, while on the other, it will maximize the opportunity to realize the rehabilitation potential of DOC patients due to timely transfer to specialized centers.
Conclusion. If the term “prolonged disorder of consciousness” is accepted by professional communities of specialists (critical care physicians, neurologists, neurosurgeons, etc.), it will be used in guidelines for the management of DOC patients.
Assessing the water quality of Suva foreshore for the establishment of estuary and marine recreational water guidelines in the Fiji Islands
Authors: Lal Praneel Pranesh , Juste-Poinapen M.S. Natacha , Poinapen Johann 
Published: August 2021

Abstract
The Standards for water quality in Fiji defined in the Environment Management Regulations 2007 only relate to effluent discharge into the environment. Urbanisation is contributing to wastewater contamination in receiving estuary and marine recreational waters, thus requiring specific guidelines. To create a baseline for this, a sampling programme with relevant physico-chemical and biological parameters was implemented at 3 sites along the Suva foreshore, for 8 consecutive months, during low and high tides. Analysis was done in triplicates, using standard methods approved for the examination of water and wastewater. In the absence of relevant Fiji guidelines, the results were compared with ANZECC (2000) guidelines for estuary and marine waters. Low DO levels, high COD, TN, NH3, TP, OP and heavy metal concentrations were measured in all 3 sites. For instance, TN and NH3 concentrations as high as 4.44 ±0.99 mg/L and 2.58 ± 0.89 mg/L respectively were recorded in Wailea river (Site 2). The colony counts for the TC, FC and E. coli were in most cases above the limits. These results confirm that wastewater discharges add to the inherent levels of parameters in receiving water bodies and support the need for specific, robust Fiji standards to better monitor water quality in foreshore areas.
Integrated community-based interventions for chronic obstructive pulmonary disease (COPD)：A systematic review and meta-analysis (Preprint)
Authors: Wang Zihui , Cai Guannan , Zhan Zhiqing , Chen Yutong , Zhang Qing , Tian Heshen , Li Wenjie , Zhou Yumin , Ran Pixin 
Published: August 2021

BACKGROUND

Limited evidence supports integrated community-based interventions for chronic obstructive pulmonary disease (COPD) patients. We aimed to assess whether integrated community-based interventions could result in better health outcomes.

OBJECTIVE

We aimed to assess whether integrated community-based interventions could result in better health outcomes.

METHODS

Relevant articles published from January 1, 2005, to October 15, 2020 were obtained. A total of 28 reports with randomized controlled trials (RCTs) were finally included in this meta-analysis.

RESULTS

Integrated community-based interventions could reduce all-cause hospitalization days per patient [weighted mean difference (95% confidence interval) -1.50 (-2.39, -0.61)], improve 6-minutes walking distance [WMD (95% CI) 10.75 (10.64, 10.86)], and reduce St.George's Respiratory Questionnaire total score per year [WMD (95% CI) -3.36 (-5.30, -1.42)], while could not reduce yearly decline in the lung function, all-cause mortality and all-cause hospital admissions in COPD patients. The efficiency of integrated community-based interventions might attribute to the implements of physical activity, medication management, self-management and long-term intervention (i.e., >12 months).

CONCLUSIONS

Integrated community-based interventions may have a potential to improve health-related outcomes for COPD.
Mandible Fractures
Authors: Chi John J. , Konkus Emily 
Published: August 2021

Mandible fractures are often caused by blunt or penetrating trauma and are one of the most common facial fractures. It is critical to understand facial and mandibular anatomy to best evaluate, classify, and treat mandible fractures. The primary goal of treatment is to restore the jaw to the preinjury occlusion. This can be achieved through open reduction with internal fixation or closed reduction with maxillomandibular fixation (MMF) in conjunction with dietary changes and/or physiotherapy. The main risks and concerns in mandible fracture management are infection, malunion, airway compromise, pain, and temporomandibular joint (TMJ) dysfunction. This chapter will provide a brief overview of facial and mandibular anatomy as well as common treatment methods and surgical interventions.

This review contains 17 figures, 2 tables, and 43 references
Key words: Mandibular fracture, maxillomandibular fixation, occlusion, malunion, closed reduction, open reduction, TMJ dysfunction
THE INFLUENCE OF READING HABITSAND READING STRATEGIES ON STUDENTS’ READING COMPREHENSION ATJUNIOR HIGH SCHOOL 1 IN THE DISTRICT OFBENAI-KUANSING
Authors: Syamsinar Tengku 
Published: August 2021

CIRC is a cooperative learning program that involves a series of activities derived from research on reading comprehension and writing skill. Students work in four-member heterogeneous learning teams. After the teacher introduces a story from a basal text or trade book, students work in their teams on a prescribed series of activities relating to the story. In this research, two classes were involved; one class as the experimental group, which was treated by using CIRC method and another one as control group was taught without using CIRC method. For both experimental and control groups, pre-test and post-test were administered to the students. The data were analyzed by using statistical analysis. To know the result whether it was be statistically significant, it was analyzed by using t-test. This study investigated the effect of using cooperative integrated reading and composition (circ) method on students’ reading comprehension and writing skill. Data the research were collected from 30 students of SMAN 1 Rimba Melintang. The findings showed Reading Comprehension that the average score of the pre-test was 50.83 and post-test was 76.17. and findings showed Writing Skill that the avearge score of the pre-test was 62.63 and post-test was 74.67.Therefore, the null hypothesis was rejected and the alternative hypothesis was accepted. There was significant effect of using cooperative integrated reading and composition (CIRC) method on students’ reading comprehension and writing skill at SMAN 1 Rimba Melintang. Keywords: Cooperative integrated reading and composition (CIRC) Reading Comprehension,and Writing Skill.
PENGARUH SUPERVISI KEPALA MADRASAH DAN KOMITMEN KERJA GURU TERHADAP PROFESIONALITAS GURU PADA MADRASAH TSANAWIYAH NEGERI 1 KOTA PEKANBARU
Authors: Mardhiyah Mardhiyah 
Published: August 2021

Pengaruh supervisi Kepala Madrasah dan komitmen kerja guru terhadap profesionalitas guru pada MTsN 1 Kota Pekanbaru dilakukan melalui uji korelasi ganda dan uji regresi linier berganda. Melalui uji korelasi ganda terdapat pengaruh yang signifikan antara supervisi Kepala Madrasah dengan profesionalitas guru, hal ini diperoleh nilai sig. untuk supervisi Kepala Madrasah sebesar 0.000. Hasil ini jika dibandingkan dengan nilai probabilitas 0.05, maka ia lebih kecil (0.000 < 0.05). Selain uji korelasi ganda juga dilakukan uji regresi linier berganda hasil analisis signifikan dengan nilai F sebesar 11.066 dengan signifikansi 0.000. Nilai taraf signifikansi 0.00 tersebut adalah lebih rendah dari pada 0.05, sehingga dapat disimpulkan bahwa supervisi Kepala Madrasah dan komitmen kerja guru secara bersama berpengaruh terhadap profesional guru di MTsN 1 Kota Pekanbaru, dengan taraf siginifikansi 0.00. maka Kepala Madrasah perlu terus melakukan Pengembangan supervisi dan program-program peningkatan komitmen kerja guru di MTsN 1 Kota Pekanbaru agar profesional guru tetap terus terjaga. Kata Kunci: Guru Profesional, Uji Korelasi Ganda, Uji Regresi Linier Berganda
FENOMENA KORUPSI DI INDONESIA; Perspektif Hukum Pidana Islam
Authors: Zikri Ahmad 
Published: August 2021

Masih tingginya kasus tindak pidana korupsi menunjukkan pemberantasan korupsi belum maksimal. Salah satu faktor penyebabnya adalah lemahnya hukuman yang diberikan kepada pelaku tindak pidana korupsi. hukuman
diberikan mempunyai tujuan pemidanaan sebagai Preverensi Khusus bagi pelaku tindak pidana untuk tidak mengulangi perbuatannya dan Prevefensi Umum selain pelaku agar tidak melakukan tindakan serupa. Lebih lanjut, hukuman bagi pelaku tindak pidana korupsi belum mampu memberikan efek jera. Bentuk hukuman dan ukurannya dalam hukum pidana islam diserahkan kepada hakim karena ini dikategorikan kepada Ta’zir. Akan tetapi lebih baik jika dilakukan formulasi dalam sebuah Qanun. Hukum pidana islam memberikan porsi yang besar kepada Hakim dalam pemberian hukuman bagi pelaku tindak pidana sehingga menimbulkan disparitas putusan
Misinterpretation of zircon ages in layered intrusions
Authors: Latypov R. , Chistyakova S. 
Published: August 2021

Abstract
A recent re-interpretation of the Bushveld Complex and other layered intrusions as stacks of randomly emplaced, amalgamated sills is mostly fuelled by finding of zircon ages that are not getting progressively younger from the base upwards, as expected from a classical model for the formation of layered intrusions. Rather, they display several reversals from older to younger ages and vice-versa with moving up-section through the layered intrusions. Here, we show that the reported zircon ages are at odds with the relative ages of rocks as defined by cross-cutting relations in potholes of the Bushveld Complex. This indicates that interpretation of the zircon isotopic data as the emplacement age of the studied rocks/units is incorrect, making a new emplacement model for layered intrusions baseless. This conclusion is further buttressed by the phase equilibria analysis showing that regular cumulate sequences of layered intrusions are not reconcilable with a model of randomly emplaced sills. In this model, the late sills are free to intrude at any stratigraphic position of the pre-existing rocks, producing magmatic bodies with chaotic crystallization sequences and mineral compositional trends that are never observed in layered intrusions. There are thus no valid justifications for the re-evaluation of the current petrological model of the Bushveld Complex and other layered intrusions as large, long-lived and largely molten magma chambers. A fundamental implication of this analysis is that the current high-precision U-Pb TIMS ages from layered intrusions are inherently unreliable on the scale of several million years and cannot therefore be used for rigorous estimations of the timing of crystallization, duration of magmatism, and cooling of these intrusions.
A review on potential technological advances for fashion retail
Authors: Fernandes Clara E. , Morais Ricardo 
Published: August 2021

This technical paper will assess new technological advances that could change the way we buy clothes, exploring existing solutions that are still commonly confused with each other: Smart fitting rooms (SFR), interactive mirrors (IM), Virtual Reality (VR), and Augmented Reality (AR). The methodological approach based on an exploratory research will start with a literature review on SFR and IM, comparing the main differences between these two technologies and addressing their unsuccessful attempts in retail. Our research will also assess daily technologies, which could possibly improve the customer’s experience with online shopping, as well as customers with reduced mobility.
With smart gadgets in every corner, consumers are more difficult to convince with innovative products. We will propose future possibilities for fashion retail, where results will be presented as a first approach, in hopes of creating innovative solutions for the future. Moreover, sustainable implications related with this approach will be addressed in our additional considerations. This technical study considers only two basic solutions that were eventually too complicated to fit into fashion retail, exploring additional solutions that could change these limitations.
Although explored and researched in the last years, solutions like IM and SFR were once part of what was considered the future of fashion retail. However, poor business models and lack of technological advances at the time limited these solutions. New technologies such as Augmented Reality (AR), Virtual Reality (VR) and Mixed-Reality (MR), combined with the latest smartphone evolution could relaunch solutions like these.
Efektivitas Program GeMa CerMat dalam Peningkatan Pengetahuan tentang Obat bagi Masyarakat Ngemplak
Authors: Shintia Nirma Atin 
Published: August 2021

AbstrakLatar Belakang: Salah satu masalah serius yang dihadapi dunia yaitu penggunaan obat yang tidak rasional. Penggunaan obat yang tidak tepat ini dapat terjadi dalam praktek swamedikasi. Swamedikasi ini merupakan fenomena yang terjadi secara global baik negara maju maupun di negara berkembang. Gerakan Masyarakat Cerdas Menggunakan Obat (GeMa CerMat) merupakan program yang dibuat oleh Kementrian Kesehatan Republik Indonesia pada tahun 2015 sebagai salah satu upaya untuk menjawab berbagai permasalahan yang ada di masyarakat terkait obat. Penelitian ini bertujuan untuk memperoleh gambaran efektivitas GeMa CerMat dalam meningkatkan pengetahuan masyarakat tentang aspek aspek penggunaan obat yang benar.Metode: Penelitian kuantitatif dengan desain quasi experimental one-group pretest- posttest cross-sectional. Pengambilan sampel menggunakan metode purposive sampling. Analisis yang digunakan yaitu uji statistik Paired t-test.Hasil: Hasil analisis Paired t-test menunjukkan adanya perbedaan yang signifikan pada tingkat pengetahuan peserta saat sebelum dan saat sesudah mengikuti Gema Cermat dengan nilai p: 0,0001 (p < 0.05).Kesimpulan: Hasil penelitian menunjukkan Program Gema Cermat efektif dalam meningkatkan pengetahuan tentang obat bagi masyarakat. Kata Kunci:.Gema Cermat, Tingkat Pengetahuan,Penggunaan Obat Rasional, Swamedikasi