bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism for the Spatial Pattern of the Amplitude Changes in Tropical Intraseasonal and Interannual Variability under Global Warming
Authors: Zhang Jiayu , Huang Ping , Liu Fei , Zhou Shijie 
Published: March 2021

AbstractThis study investigates what forms the spatial pattern of the amplitude changes in tropical intraseasonal and interannual variability—represented by the two most important variables, precipitation (ΔP′) and circulation (Δω′)—under global warming, based on 24 models from the phase 5 of the Coupled Model Intercomparison Project (CMIP5). Diagnostic analyses reveal that the moisture budget and thermodynamic energy equations related to the ΔP′ and Δω′ proposed separately in previous studies are simultaneously tenable. As a result, we investigate the mechanism for the spatial pattern of Δω′ from the perspective of the moist static energy (MSE) balance mainly considering the positive contribution from vertical advection. Therefore, based on the simplified MSE balance, the spatial pattern of Δω′ can be approximately projected based on three factors: background circulation variability ω′, the vertical gradient of mean-state MSE , and its future change . Under global warming, the middle-level vertical gradient of MSE increases slightly over the Indian Ocean and the Maritime Continent and decreases over the equatorial Pacific where the increase in sea surface temperature (SST) exceeds the tropical mean. The vertical gradient of mean-state MSE is modified by the increase in vertical gradients of moisture and dry static energy (DSE) simultaneously. In short, the change in the vertical gradient of mean-state MSE under global warming can influence the moisture budget and thermodynamic energy balances, resulting in the spatial pattern of ΔP′ and Δω′ at intraseasonal and interannual time scales consequently, mainly determined by the lower boundary moisture condition in the response of the SST change pattern.
Comparing Observations and Simulations of the Streamwise Vorticity Current and the Forward Flank Convergence Boundary in a Supercell Storm
Authors: Schueth Alex , Weiss Christopher , Dahl Johannes M.L. 
Published: March 2021

AbstractThe forward-flank convergence boundary (FFCB) in supercells has been well documented in many observational and modeling studies. It is theorized that the FFCB is a focal point fore baroclinic generation of vorticity. This vorticity is generally horizontal and streamwise in nature, which can then be tilted and converted to mid-level (3-6 km AGL) vertical vorticity. Previous modeling studies of supercells often show horizontal streamwise vorticity present behind the FFCB, with higher resolution simulations resolving larger magnitudes of horizontal vorticity. Recently, studies have shown a particularly strong realization of this vorticity called the streamwise vorticity current (SVC). In this study, a tornadic supercell is simulated with the Bryan Cloud Model at 125-m horizontal grid spacing, and a coherent SVC is shown to be present. Simulated range-height indicator (RHI) data show the strongest horizontal vorticity is located on the periphery of a steady-state Kelvin-Helmholtz billow in the FFCB head. Additionally, similar structure is found in two separate observed cases with the Texas Tech University Ka-band (TTUKa) mobile radar RHIs. Analyzing vorticity budgets for parcels in the vicinity of the FFCB head in the simulation, stretching of vorticity is the primary contributor to the strong streamwise vorticity, while baroclinic generation of vorticity plays a smaller role.
Strategies to Identify Mesenchymal Stromal Cells in Minimally Manipulated Human Bone Marrow Aspirate Concentrate Lack Consensus
Authors: Ruoss Severin , Walker J. Todd , Nasamran Chanond A. , Fisch Kathleen M. , Paez Conner J. , Parekh Jesal N. , Ball Scott T. , Chen Jeffrey L. , Ahmed Sonya S. , Ward Samuel R. 
Published: March 2021

Background: There is a need to identify and quantify mesenchymal stromal cells (MSCs) in human bone marrow aspirate concentrate (BMAC) source tissues, but current methods to do so were established in cultured cell populations. Given that surface marker and gene expression change in cultured cells, it is doubtful that these strategies are valid to quantify MSCs in fresh BMAC. Purpose: To establish the presence, quantity, and heterogeneity of BMAC-derived MSCs in minimally manipulated BMAC using currently available strategies. Study Design: Descriptive laboratory study. Methods: Five published strategies to identify MSCs were compared for suitability and efficiency to quantify clinical-grade BMAC-MSCs and cultured MSCs at the single cell transcriptome level on BMAC samples being used clinically from 15 orthopaedic patients and on 1 cultured MSC sample. Strategies included (1) the guidelines by the International Society for Cellular Therapy (ISCT), (2) CD271 expression, (3) the Ghazanfari et al transcriptional profile, (4) the Jia et al transcriptional profile, and (5) the Silva et al transcriptional profile. Results: ISCT guidelines did not identify any MSCs in BMAC at the transcriptional level and only 1 in 9 million cells at the protein level. Of 12,850 BMAC cells, 9 expressed the CD271 gene. Only 116 of 396 Ghazanfari genes were detected in BMAC, whereas no cells expressed all of them. No cells expressed all Jia genes, but 25 cells expressed at least 13 of 22. No cells expressed all Silva genes, but 19 cells expressed at least 8 of 23. Most importantly, the liberalized strategies tended to identify different cells and most of them clustered with immune cells. Conclusion: Currently available methods need to be liberalized to identify any MSCs in fresh human BMAC and lack consensus at the single cell transcriptome and protein expression levels. These different cells should be isolated and challenged to establish phenotypic differences. Clinical Relevance: This study demonstrated that improved strategies to quantify MSC concentrations in BMAC for clinical applications are urgently needed. Until then, injected minimally manipulated MSC doses should be reported as rough estimates or as unknown.
Examination of the ‘5-2-1-0’ Recommendations in Racially Diverse Young Children Exposed to Tobacco Smoke
Authors: Mahabee-Gittens E. Melinda , Ding Lili , Merianos Ashley L. , Khoury Jane C. , Gordon Judith S. 
Published: March 2021

Purpose: The ‘5-2-1-0’ guidelines recommend that children: eat ≥5 servings of fruits/vegetables (‘5’), have ≤2 hours of screen-time (‘2’), have ≥1 hour of activity (‘1’), and drink 0 sugar-sweetened beverages (‘0’) daily. The pediatric emergency department (PED) treats children at risk for obesity and tobacco smoke exposure (TSE). We examined body mass index (BMI), overweight, obesity, TSE, and ‘5-2-1-0’ rates in children with TSE in the PED. Design: Cross-sectional study of PED children. Setting: The PED of a children’s hospital. Sample: Children with TSE >6 months-5 years old (N = 401). Measures: Sociodemographics, ‘5-2-1-0’ behaviors, BMI, and cotinine-confirmed TSE. Analysis: Associations between ‘5-2-1-0’ and sociodemographics were examined with logistic regression. Results: Mean (SD) age = 2.4 (1.6) years; 53.1% were Black; 65.8% had low-income; and 93.4% had TSE. Of 2-5-year-olds, mean (SD) BMI percentile was 66.2 (30.1), 16.1% were overweight and 20.6% were obese. In total, 10.5% attained ‘5’, 72.6% attained ‘2’, 57.8% of 2-5-year-olds attained ‘1’, and 9.8% attained ‘0’. Compared to White children, “other” race children were more likely to meet ‘5’ (aOR(95% CI):4.67(1.41, 5.45)); 2-5-years-olds (aOR(95%CI):0.60(0.38, 0.95)) and Black children (aOR(95%CI):0.36(0.21, 0.60)) were at decreased odds to meet ‘2’ compared to younger or White children, respectively. Compared to younger children, 2-5-year-olds were at decreased odds to meet ‘0’ (aOR(95%CI):0.08(0.02, 0.26)). Conclusion: Racially diverse, low-income children with TSE had low ‘5-2-1-0’ attainment. Interventions are needed to improve lifestyle habits in this population.
Prevalence of Hand Malformations in Patients With Moebius Syndrome and Their Management
Authors: Telich-Tarriba Jose E. , Navarro-Barquin David F. , Verdezoto-Gaibor Karol , Cardenas-Mejia Alexander 
Published: March 2021

Background: Moebius syndrome is a disorder characterized by facial and abducens nerve paralysis. Patients can present a wide range of upper extremity malformations. Literature focused on orthopedic manifestations of Moebius syndrome shows variability in the prevalence and clinical presentation of upper extremity anomalies. The aim of this work is to evaluate the prevalence of upper extremity malformations in patients with Moebius syndrome, clarify its various clinical presentations, and present treatment strategies for their management. Methods: This is a retrospective, cross-sectional study including patients with Moebius syndrome and upper extremity malformations between 2012 and 2019. Data include demographic characteristics, Moebius syndrome subtype, type of malformation, affected extremity, and surgical procedures underwent. Quantitative data were recorded as mean (standard deviation [SD]), and qualitative data were expressed in terms of totals and percentages. Statistical association between Moebius syndrome subtype and development of upper extremity anomalies was evaluated using binary logistic regression. Results: Twenty-five out of 153 patients (16.3%) presented upper extremity malformations (48% male). Mean age of presentation was 9.08 ± 9.43 years. Sixty-eight percent of the malformations were unilateral. The most common presentations included Poland syndrome and simple syndactyly with 8 cases each (32%), followed by 5 cases of brachysyndactyly (20%), 3 cases of amniotic band syndrome (12%), and 1 case of cleft hand (4%). No statistical association was found between Moebius syndrome subtype and odds ratio for development of upper extremity anomalies. Thirteen patients (52%) underwent reconstructive procedures. Conclusion: Poland syndrome and syndactyly are the most common anomalies in patients with Moebius syndrome. Patients may present with a wide range of hand malformations, each patient should be carefully evaluated in order to determine whether surgical treatment is needed and to optimize rehabilitation protocols.
Artbooks as witness of everyday resistance: Using art with displaced children living in Johannesburg, South Africa
Authors: Clacherty Glynis 
Published: March 2021

Artbooks, which are a combined form of picture and story book created using mixed media, can be a simple yet powerful way of supporting children affected by war and displacement to tell their stories. They allow children to work through the creative arts, which protects them from being overwhelmed by difficult memories. They also allow, even very young children, to show us how they cope with past violence and present injustice by recalling and representing the small everyday overcomings of their lives – a garden they planted in DRC, a mother who walks them across a busy Johannesburg street, a curtain blowing in the door of their new home – just as it did in their old home. The books allow them to witness to the injustice of xenophobic violence by neighbours and the immoveable bureaucracy attached to accessing documents, through representing the small details of their lives in crayons and paint. Making artbooks also allows for some measure of meaning-making in the chaos of the everyday in a hostile city where their parents struggle to maintain a normal life for them. Books are also a powerful way for children to safely share their stories and advocate for changed attitudes, laws and policies in the increasingly migrant-hostile South African society. The article will tell the story of a book-making project run over a number of years at a community counselling centre that works with families on the move in Johannesburg South Africa. It will also describe how some of the children’s books have become a powerful advocacy tool through their inclusion in the digital library of the African Storybook project. The article will explore some of the practical details of the project and the theory around the power of the representation of the everyday which we are beginning to derive from the work.
A multi-objective optimization for resource allocation of emergent demands in cloud computing
Authors: Chen Jing , Du Tiantian , Xiao Gongyi 
Published: March 2021

AbstractCloud resource demands, especially some unclear and emergent resource demands, are growing rapidly with the development of cloud computing, big data and artificial intelligence. The traditional cloud resource allocation methods do not support the emergent mode in guaranteeing the timeliness and optimization of resource allocation. This paper proposes a resource allocation algorithm for emergent demands in cloud computing. After building the priority of resource allocation and the matching distances of resource performance and resource proportion to respond to emergent resource demands, a multi-objective optimization model of cloud resource allocation is established based on the minimum number of the physical servers used and the minimum matching distances of resource performance and resource proportion. Then, an improved evolutionary algorithm, RAA-PI-NSGAII, is presented to solve the multi-objective optimization model, which not only improves the quality and distribution uniformity of the solution set but also accelerates the solving speed. The experimental results show that our algorithm can not only allocate resources quickly and optimally for emergent demands but also balance the utilization of all kinds of resources.
HIV Prevention and Care of Transgender Women in an HIV and STI Clinic in the Paris Metropolitan Area
Authors: Azadi Bahar , Zélie Julia , Michard Florence , Yazdanpanah Yazdan 
Published: March 2021

Abstract
HIV infection burden is globally high among transgender women (TGW) and particularly in TGW migrant sex workers and TGW subpopulations with structural inequalities like racism and classism. In addition to stigma related to transphobia, migrant TGW face multiple forms of discrimination because of intersection with other experiences of stigma related to migration and working as sex workers in the host society. This study explores the experiences of TGW seeking care in an HIV and STI clinic in Paris, to evaluate medical adherence, namely, the degree to which a patient is regularly followed up in care and adequately takes the treatment, and trans individuals' social inclusion in this health institution. We examined the different forms of HIV-associated stigma among TGW. A qualitative study was conducted using semistructural in-depth interviews with TGW receiving HIV care and HIV preventive measures. A description is given of how a community-based participation policy and practice in this clinic integrate an intersectional approach among TGW. This results in a high rate of medical adherence in TGW migrants and could lead to social integration.
Characteristics and long-term outcomes of childhood glaucoma: a retrospective-cohort study
Authors: Surukrattanaskul Supawan , Suvannachart Pukkapol , Chansangpetch Sunee , Manassakorn Anita , Tantisevi Visanee , Rojanapongpun Prin 
Published: March 2021

Purpose: To evaluate the clinical characteristics and treatment outcomes of patients with childhood glaucoma. Methods: We retrospectively reviewed the data of patients with childhood glaucoma who visited the glaucoma clinics at the Queen Sirikit National Institute of Child Health and the King Chulalongkorn Memorial Hospital between January 2008 and January 2018. The diagnosis was based on the Childhood Glaucoma Research Network classification. We recorded their clinical characteristics and requirement of any glaucoma interventions. Results: A total of 691 eyes from 423 patients were included in this study. The patients predominantly comprised boys. The average follow-up duration was 71.3±63.8 months. The mean age at presentation was 3.9±4.4 years. Most patients presented with a high initial intraocular pressure (IOP) of 28.5±11.2 mmHg. Glaucoma associated with non-acquired ocular anomalies (22.9%) was the most common subtype, followed by primary congenital glaucoma (20.8%). We recorded a family history of glaucoma in 6.4% of patients. Most patients had bilateral glaucoma (63.4%) and required at least one intervention (51.5%). The average IOP at the latest follow-up visit was 19.1±10.8 mmHg. All glaucoma types had significantly lower IOP, compared to that at their baselines (all p<0.001). Moreover, most patients had an unfavourable visual acuity (49.5%) at their latest visit. Conclusions: Secondary glaucoma associated with non-acquired ocular anomalies is the most common subtype of glaucoma. All subtypes, including primary glaucoma, were sporadic. The majority of patients had unfavourable visual outcomes. These real-world findings are fundamental to acquire a better understanding of childhood glaucoma.
Judgement, capabilities and practice: how surgical supervisors make judgements about trainee readiness to practise
Authors: Bussey M 
Published: March 2021

Introduction In the UK, acting as clinical supervisors, consultant surgeons make judgements about trainee performance every day. Their professional judgements provide the primary mechanism for trainee progression through and completion of surgical training, and have a consequent impact on patient safety. The exact manner in which surgical supervisors make judgements, however, has long been unclear. Correspondingly, the aim of this study was to determine whether there were particular patterns of judgement used and how far these judgements were influenced by factors in the training environment. Methods This was a qualitative study, using in-depth, semi-structured interviews with six consultant clinical supervisors from different specialties, regions and backgrounds. The interviews were audio-recorded, transcribed, coded and thematically analysed, allowing theoretical concepts and ideas to emerge. Results From the analysis, a universal picture of judgement began to form. It became apparent that all the participants used a similar approach to making decisions about the amount of trust that could be granted to trainees carrying out clinical work. Their approach focused on four categories of trainee capability: competence, decision making, administration and relationships. Conclusions The identification of a latent pattern of supervisor judgement lends support to the notion that professional judgement in workplace assessment is based on the supervisor’s global sense of trainee capability and that it is a result of the trainee–trainer relationship. This study has resulted in the creation of an explicit framework that reflects this pattern of judgement, which could serve as a useful reflective tool for both supervisors and trainees.
Principles to tailor the saturable and reverse saturable absorption of epsilon-near-zero material
Authors: Ma Hao , Zhao Yuanan , Shao Yuchen , Lian Yafei , Zhang Weili , Hu Guohang , Leng Yuxin , Shao Jianda 
Published: March 2021

Indium tin oxide (ITO) films have recently emerged as a new class of functional materials for nonlinear optical (NLO) devices due to their exotic properties around epsilon-near-zero (ENZ) wavelength. Here, we experimentally investigated and tailored the NLO absorption properties of ITO films. The NLO absorption response of ITO films is investigated by using the femtosecond Z-scan measurement technique at two different wavelengths of 1030 nm (out of ENZ region) and 1440 nm (within ENZ region). Interestingly, we observed conversion behavior from saturable absorption (SA) to reverse saturable absorption (RSA) at 1030 nm with the increasing incident laser intensity, whereas only SA behavior was observed at 1440 nm. We demonstrate that SA behavior was ascribed to ground-state free electrons bleaching in the conduction band, and RSA was attributed to three-photon absorption. Moreover, results reveal that ITO film shows more excellent SA performance at 1440 nm with a nonlinear absorption coefficient of

∼
−
23.2

cm
/
GW

and a figure of merit of

∼
1.2
2
×

10

−
1
6

esu
·
cm

. Furthermore, we tailored the SA and RSA behaviors of ITO films at 1030 and 1440 nm wavelengths via post-annealing treatment. The modulatable NLO absorption was ascribed to the changing of free-carrier concentration in ITO films via annealing treatment. The experimental findings offered an inroad for researchers to tailor its NLO absorption properties by changing the free-carrier concentration through chemical modification such as annealing, oxidation, or defect implantation. The superior and tunable nonlinear optical response suggests that ITO film might be employed as a new class material with potential applications in novel optical switches or optical limiters to realize the all-optical information process.
Self-management interventions for adults living with Chronic Obstructive Pulmonary Disease (COPD): The development of a Core Outcome Set for COMPAR-EU project
Authors: Camus-García Estela , González-González Ana Isabel , Heijmans Monique , Niño de Guzmán Ena , Valli Claudia , Beltran Jessica , Pardo-Hernández Hector , Ninov Lyudmil , Strammiello Valentina , Immonen Kaisa , Mavridis Dimitris , Ballester Marta , Suñol Rosa , Orrego Carola 
Published: March 2021

Background
A large body of evidence suggests that self-management interventions (SMIs) may improve outcomes in chronic obstructive pulmonary disease (COPD). However, accurate comparisons of the relative effectiveness of SMIs are challenging, partly due to heterogeneity of outcomes across trials and uncertainty about the importance of these outcomes for patients. We aimed to develop a core set of patient-relevant outcomes (COS) for SMIs trials to enhance comparability of interventions and ensure person-centred care.

Methods
We undertook an innovative approach consisting of four interlinked stages: i) Development of an initial catalogue of outcomes from previous EU-funded projects and/or published studies, ii) Scoping review of reviews on patients and caregivers’ perspectives to identify outcomes of interest, iii) Two-round Delphi online survey with patients and patient representatives to rate the importance of outcomes, and iv) Face-to-face consensus workshop with patients, patient representatives, health professionals and researchers to develop the COS.

Results
From an initial list of 79 potential outcomes, 16 were included in the COS plus one supplementary outcome relevant to all participants. These were related to patient and caregiver knowledge/competence, self-efficacy, patient activation, self-monitoring, adherence, smoking cessation, COPD symptoms, physical activity, sleep quality, caregiver quality of life, activities of daily living, coping with the disease, participation and decision-making, emergency room visits/admissions and cost effectiveness.

Conclusion
The development of the COPD COS for the evaluation of SMIs will increase consistency in the measurement and reporting of outcomes across trials. It will also contribute to more personalized health care and more informed health decisions in clinical practice as patients’ preferences regarding COPD outcomes are more systematically included.