bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Comparison of CT-P6 and Reference Trastuzumab for the Treatment of HER2-Positive Early-Stage and Metastatic Breast Cancer
Authors: Bae Soong June , Kim Jee Hung , Ahn Sung Gwe , Jeung Hei-Cheul , Sohn Joohyuk , Kim Gun Min , Kim Min Hwan , Kim Seung Il , Park Seho , Park Hyung Seok , Kim Jee Ye , Jeong Joon 
Published: March 2021

Abstract
Background: Here, we present the first real-world comparison of CT-P6 versus reference trastuzumab (RTZ) for the neoadjuvant treatment of patients with HER2-positive EBC, and for the palliative first-line treatment of patients with HER2-positive metastatic breast cancer (MBC).Methods: We retrospectively identified patients with HER2-positive EBC who had received neoadjuvant treatment with RTZ or CT-P6, plus pertuzumab, carboplatin, and docetaxel, followed by surgery, alongside patients with newly diagnosed HER2-positive MBC who had received palliative treatment with RTZ or CT-P6, plus pertuzumab and docetaxel. The primary endpoints were pathologic complete response (pCR) in the EBC cohort, and progression-free survival (PFS) in the MBC cohort. Results: A similar percentage of patients with EBC achieved a pCR with CT-P6 (74.4% [93/125]) and RTZ (69.8% [90/129]) (p=0.411). For patients with MBC, median PFS did not differ significantly between the two groups (CT-P6: 13.9 months [95% confidence intervals (CIs) not available]; RTZ: 18.4 months [95% CIs 12.5–24.3]; p=0.653). The cardiac safety profiles of CT-P6 and RTZ were similar. Conclusions: These real-world data suggest that CT-P6 has similar effectiveness and cardiac safety to RTZ in patients with HER2-positive EBC and MBC, when administered as part of dual HER2-targeted therapy with pertuzumab plus chemotherapy in the neoadjuvant or palliative setting.
Thermally active nanoparticle clusters enslaved by
engineered domain wall traps
Authors: Tierno Pietro , Johansen Tom , Straube Arthur 
Published: March 2021

Abstract
The stable assembly of fluctuating nanoparticle clusters on a surface represents a technological challenge of widespread
interest for both fundamental and applied research.
Here we demonstrate a technique to stably confine in two dimensions
clusters of interacting nanoparticles via size-tunable, virtual magnetic traps. We use cylindrical Bloch walls arranged to form
a triangular lattice of ferromagnetic domains within an epitaxially grown ferrite garnet film. At each domain, the magnetic stray field generates an effective harmonic potential with a field tunable stiffness. The experiments are combined with theory to show that the magnetic confinement is effectively harmonic and pairwise interactions are of dipolar nature, leading to central, strictly repulsive forces. For clusters of magnetic nanoparticles, the stationary collective states arise from the competition between repulsion, confinement as the tendency to fill the central potential well. Using a numerical simulation model as a quantitative map between the experiment and theory we explore the field-induced crystallization process for larger clusters and unveil the existence of three different dynamical regimes. The present method provides a model platform for investigations of the collective phenomena emerging when strongly confined nanoparticle clusters are forced to move in an idealized, harmonic-like potential.
Decay and renormalization of a longitudinal mode in a quasi-two-dimensional antiferromagnet
Authors: Do Seung-Hwan , Zhang Hao , Williams Travis , Hong Tao , Garlea Vasile , Jang T.-H. , Cheong Sang-Wook , Park Jae-Hoon , Batista Cristian , Christianson Andrew 
Published: March 2021

Abstract
An ongoing challenge in the study of quantum materials, is to reveal and explain collective quantum effects in spin systems where interactions between different modes types are important. Here we approach this problem through a combined experimental and theoretical study of interacting transverse and longitudinal modes in an easy-plane quantum magnet near a continuous quantum phase transition. Our inelastic neutron scattering measurements of Ba2FeSi2O7 reveal the emergence, decay, and renormalization of a longitudinal mode throughout the Brillouin zone. The decay of the longitudinal mode is particularly pronounced at the zone center. To explain these observations, we develop a generalized linear spin-wave theory, including all of the one-loop corrections, which reproduces the measured mode decay and renormalization. The theoretical approach developed here is broadly applicable to quantum magnets with more than one type of low energy mode.
A model for the co-evolution of dynamic social networks and infectious disease dynamics
Authors: Nunner Hendrik , Buskens Vincent , Kretzschmar Mirjam 
Published: March 2021

Abstract
Recent research shows an increasing interest in the interplay of social networks and infectious diseases. Many studies either neglect explicit changes in health behavior or consider networks to be static, despite empirical evidence that people seek to distance themselves from diseases in social networks. We propose an adaptable steppingstone model that integrates theories of social network formation from sociology, risk perception from health psychology, and infectious diseases from epidemiology. We argue that networking behavior in the context of infectious diseases can be described as a trade-off between the benefits, efforts, and potential harm a connection creates. Agent-based simulations using a generic model implementation show that: (i) high (perceived) health risks create strong social distancing, thus resulting in low epidemic sizes, (ii) small changes in health behavior can be decisive for whether the outbreak of a disease turns into an epidemic or not, (iii) high benefits for social connections create more ties per agent, providing large numbers of potential transmission routes and opportunities for the disease to travel faster, and (iv) higher costs of maintaining ties with infected others reduce final size of epidemics only when benefits of indirect ties are relatively low. These findings suggest a complex interplay between social network, health behavior, and infectious disease dynamics. Furthermore, they contribute to solving the issue that neglect of explicit health behavior in models of disease spread may create mismatches between observed transmissibility and epidemic sizes of model predictions.
Osteoporosis Knowledge, Beliefs, and Preventive Behaviors in Postmenopausal Breast Cancer Survivors
Authors: Bailey Stacyann , Lin Jenny 
Published: March 2021

Abstract
BackgroundAromatase inhibitor therapy induces bone loss and risk of fracture in postmenopausal breast cancer survivors (PBCS). Targetable patient-level factors to mitigate osteoporosis risk in this population are underreported. Here, we assessed the association between osteoporosis knowledge and beliefs, receipt of bone mineral density, and osteoporosis preventive behaviors among PBCS. MethodsIn this cross-sectional study, early stage PBCS with diabetes mellitus (ages 55-86 years) completed the Facts on Osteoporosis Quiz, Osteoporosis Health Beliefs Scale, and Osteoporosis Preventive Behaviors cross-sectional questionnaires. Multivariate logistic regression assessed factors associated with engagement in strength-training exercise.ResultsMean age was 66.1 years with 20% self-reporting as non-Hispanic White, 40% non-Hispanic Black, 27% Hispanic, and 13% other. Osteoporosis knowledge (10.5±3.4), seriousness (14.9±3.8), and susceptibility (14.0±3.5) mean scores were low. Most (75%) PBCS were adherent to calcium and vitamin D supplements, but only 47% reported engagement in strength-training exercises. Married/partnered, higher osteoporosis knowledge and health motivation scores were associated with exercise. After adjustment of marital status and osteoporosis knowledge, only health motivation was associated with exercise (OR 5.56, 95% CI 1.35-22.93). ConclusionsPBCS are motivated to keep a healthy lifestyle despite limited osteoporosis knowledge, perceived risk, and susceptibility. However, <50% participated in strength-training exercise. Oncologic care should include osteoporosis and fracture prevention strategies, directed at encouraging cancer survivors to increase engagement in strength-training exercises and calcium intake.
Momentum-resolved electronic band structure and offsets in an epitaxial NbN/GaN superconductor/semiconductor heterojunction
Authors: Yu Tianlun , Wright John , Khalsa Guru , Pamuk Betül , Chang Celesta , Matveyev Yury , Schmitt Thorsten , Feng Donglai , Muller David , Xing Huili , Jena Debdeep , Strocov Vladimir 
Published: March 2021

Abstract
The electronic structure of heterointerfaces play a pivotal role in their device functionality. Recently, highly crystalline ultrathin films of superconducting NbN have been integrated by molecular beam epitaxy with the semiconducting GaN. We use soft X-ray angle-resolved photoelectron spectroscopy to directly measure the momentum-resolved electronic band structures for both NbN and GaN constituents of this Schottky heterointerface, and determine their momentum-dependent interfacial band offset as well as the band-bending profile into GaN. We find, in particular, that the Fermi states in NbN are aligned against the band gap in GaN, which excludes any significant electronic cross-talk of the superconducting states in NbN through the interface to GaN. We support the experimental findings with first-principles calculations for bulk NbN and GaN. The Schottky barrier height obtained from photoemission is corroborated by electronic transport and optical measurements. The momentum-resolved understanding of electronic properties elucidated by the combined materials advances and experimental methods in our work opens up new possibilities in systems where interfacial states play a defining role.
The attainment of herd immunity with a restructured risk of contact infection in compartmental models
Authors: Law Kian Boon , Peariasamy Kalaiarasu M , Ibrahim Hishamshah , Abdullah Noor Hisham 
Published: March 2021

Abstract
Introduction: The risk of contact infection among susceptible individuals in a randomly mixed population can be reduced by the presence of immune individuals and this concept is referred to as herd immunity. Although herd immunity is observed in vaccinated populations for some infectious diseases, it has never been truly attained in compartmental models such as the susceptible-infectious-recovered (SIR) model. This paper introduces a new SIR framework to overcome the limitation of the conventional SIR model in attaining herd immunity.Methods: Two SIR models were newly developed based on the reduced risk of contact infection. The first model A assumes that the risk of contact infection reduces as soon as susceptible individuals are infected and move from class S(t) to I(t), therefore incorporating prevalence of both infectious and susceptible individuals into its force of infection. The second model B assumes the risk of contact infection would reduce after infected individuals have recovered from infection and move from class I(t) to R(t), therefore incorporating the prevalence of infectious and the inverse of prevalence of recovered individuals into its force of infection. Then, numerical simulations were applied to obtain approximate solutions for all three conventional SIR model, new SIR model A and model B for comparison under exact and arbitrary conditions with β = 0.3 and σ = 0.1 to mimic the infection dynamics with basic reproduction ratio (r0) of 3.0 and herd immunity threshold (HIT) of 0.667 (66.7%).Results and discussion: All three models performed likewise at the initial stage of the epidemic. The conventional SIR model simulated the epidemic diminishing when 94.0% of the population had been infected and recovered, way above its HIT. Model A simulated the epidemic waning when 66.7% of the population had been infected and recovered, in line with its HIT. However, the model conceptualized herd immunity incorrectly. Model B simulated the epidemic waning at 75.6%, slightly above its HIT and was more in line with the fundamental of herd immunity. The difference between model A and model B can be attributed to the proportion of infectious individuals, and this would increase in infectious disease with high transmissibility. The threshold theorem derived based on r0 may not be sufficient for optimal control and eradication of infectious disease with high transmissibility like the COVID-19.Conclusion: The newly developed SIR model that includes the inverse of proportion of recovered individuals into its force of infection is more accurate and credible for modelling infection with high transmissibility or vaccine-induced herd immunity in a randomly mixed population, especially in COVID-19.
PEMAHAMAN IDENTITAS ETNIK (ETHNIC IDENTITY) UNTUK MENGEMBANGKAN TOLERANSI MASYARAKAT KOTA METRO LAMPUNG
Authors: Widodo Widodo 
Published: March 2021

Keanekaragaman suku, bahasa, adat, dan agama merupakan keniscayaan sekaligus menjadi kekayaan bangsa Indonesia. Namun, dinamika interaksi sosial dalam masyarakat sering mengakibatkan terjadinya konflik antar etnis maupun antar agama karena kurangnya pengetahuan dan pemahaman terhadap Ethnic Identity (Identitas Etnik). Artikel ini bertujuan memotret keragaman masyarakat dan pemahaman identitas etnis dalam mengembangkan toleransi masyarakat Kota Metro, Lampung, menggunakan pendekatan kualitatif deskriptif. Data dikumpulkan melalui pengamatan langsung serta menelaah berbagai sumber dari media cetak maupun elektronik. Hasilnya menunjukkan bahwa; a) berdasarkan telaah berita pada media massa, tidak pernah terjadi konflik yang melibatkan suku dan agama di Kota Metro seperti yang terjadi di beberapa kabupaten lainnya di Provinsi Lampung, b) Adanya kerjasama antar pemerintah dan masyarakat untuk mewujudkan kerukunan hidup yang harmonis melalui kegiatan rutin seperti peringatan hari jadi Kota Metro dan upacara Pemilihan Bujan Gadis Lampung (Buyai Nuban) yang melibatkan seluruh elemen masyarakat tanpa membedakan latar belakang etnis yang bersangkutan. Kata Kunci: Identitas Etnis, Toleransi, Keanekaragaman
PARTICIPATORY DESIGN DALAM KAJIAN PERANCANGAN STANDARDISASI MUSEUM SULTAN MAHMUD BADARUDDIN II
Authors: Budi Haswati Sri Maharani , Safari Erica Albertina , Harwinanto Agrie Pratama 
Published: March 2021

Dalam beberapa dekade terakhir, berbagai jenis museum di berbagai belahan dunia semakin gencar mengajak masyarakat untuk terlibat merayakan gairah berbudaya melalui berbagai jenis aktivitas. Mereka memperkenalkan mediamedia yang variatif dan berhasil mematahkan stereotip lama bahwa museum cenderung dikenal sebagai bangunan tempat penyimpanan koleksi dari warisan masa lampau semata. Sehingga muncul gagasan bahwa ditawarkannya pengalaman yang interaktif merupakan salah satu faktor utama yang mendorong orang-orang mau kembali mengunjungi museum. Apalagi, idealnya keberadaan museum dapat pula berkontribusi terhadap pemberdayaan komunitas masyarakat setempat. Namun faktanya, sebagian besar museum di luar Jawa masih jauh tertinggal di belakang dan masih terhalang oleh keterbatasan dana serta sumber daya manusia dalam upaya mengembangkan kualitasnya secara mandiri. Maka dari itu, penerapan Participatory Design menjadi sebuah alternatif di antara pendekatan desain konvensional lain yang dapat dimanfaatkan untuk menjembatani visi misi museum dengan kebutuhan masyarakat yang disasarnya. Penelitian ini merupakan tahapan awal dari perancangan desain yang menggunakan metode kombinasi (Observasi, wawancara, hingga analisis konten), dimaksudkan untuk mengidentifikasi kendala yang dihadapi oleh museum Sultan Mahmud Badaruddin II sehingga dapat menawarkan rancangan solusi yang tepat dari sudut pandang keilmuan desain. Sekaligus berfungsi merumuskan data siap olah yang dibutuhkan dalam tahapan perancangan desain selanjutnya agar mencapai standardisasi museum yang telah ditargetkan.
Kata kunci: Museum, Participatory Design, Desain, Komunitas
Endoscopic hemostasis in the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature
Authors: Feleshtynskyi Ya. P. , Oparin S. O. , Sorokin B. V. , Boiarska M. G. , Lutsenko D. V. 
Published: March 2021

Objective. To improve the efficacy of endoscopic hemostasis for the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature.
Materials and methods. In 2017-2020 yrs period the analysis of efficacy of endoscopic hemostasis was done in 160 patients, ageing 40-85 yrs old, for the ulcer gastro-duodenal hemorrhage. The patients were distributed into two groups: the main - 80 patients, in whom high-frequency biological welding electro-ligature was performed, and a control one - 80 patients, in whom monopolar thermal argon-plasm coagulation was conducted.
Results. In the main Group a primary hemostasis was achieved in 77 (96.3%) patients. Early recurrence of hemorrhage have occurred in 3 (3.8%) patients. In a control Group a primary hemostasis was achieved in 66 (82.5%) patients. Recurrence of the hemorrhage have occurred in 14 (17.5%) patients.
Conclusion. Endoscopic hemostasis for the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature, is achieved due to the impedance action of modulated signal of a high-frequency current as well as the adaptive system of automatic guidance of the welding process and a contact between special endoscopic probe, owing a concave electrode, with bleeding vessel, leading to its complete obliteration. Application of welding electro-ligature for endoscopic hemostasis in the ulcer gastro-duodenal hemorrhage, using high-frequency biological welding electro-ligature, guarantees more secure residual hemostasis, than application of monopolar thermal argon-plasm coagulation, peculiarly in hemorrhage from vessels owing 2 - 4 mm diameter. As a result, the hemorrhage recurrence rate have had reduced down to 3.8% (in the control Group - 18.0%).
Procedure of complex braided wrapping of ascending aorta in her poststenotic dilation while doing correction of aortal stenosis
Authors: Popov V. V. , Bolshak A. A. 
Published: March 2021

Objective. To study clinical possibilities of original procedure of the ascending aorta braid-like bandage for her poststenotic dilation while performance of the aortal stenosis surgical correction.
Materials and methods. To the main Group 196 patients were included those, who were operated on for prevailing aortal stenosis, conjoined with poststenotic dilation of ascending aorta. In accordance to the echocardiographic investigation data the ascending aorta diameter preoperatively have constituted (47.7 ± 1.7) mm. In all the patients the aortal valve prosthesis was performed together with complex braided wrapping of ascending aorta. Into the control group 121 patients were included, in whom Bentall intervention was accomplished with vascular prosthesis of ascending aorta.
Results. Hospital lethality in the main group have constituted 0.5%. Diameter of ascending aorta in the moment of hospital discharge have constituted (39.1 ± 1.5) mm, and in late follow-up period - (40.3 ± 1.1) mm.
Conclusion. Basing on clinical experience gained, it is expedient to recommend the original procedure of braided wrapping of ascending aorta in presence of her poststenotic dilation while performing surgical correction of prevailing aortal stenosis.
Traduction franco-canadienne de l’Assessment of Systematic Reviews Revised (AMSTAR 2) : validation transculturelle et fidélité interjuges
Authors: Flowers Heather , Guitard Paulette , King Judy , Fitzpatrick Elizabeth , Bérubé Daniel , Barette Julie Alexandra , Cardinal Dominique , Cavallo Sabrina , O’Neil Jennifer , Charette Marylène , Côté Laurence , Gurgel-Juarez Nalia Cecilia , Toupin-April Karine , Shallwani Shirin M. , Dorion Michelle , Rahman Prinon , Potvin-Gilbert Maude , Bartolini Vanessa , Lewis Krystina B. , Martini Rose , Lagacé Josée , Galipeau Roseline , Ranger Marie-Christine , Duquette-Laplante Fauve , Perrier Marie-France , Savard Jacinthe , Paquet Nicole , Tourigny Jocelyne , Bérubé Marie-Eve , Ba Haroon Hussein , Duong Patrick , Bigras Jacynthe , Capistran Julie , Loew Laurianne 
Published: March 2021

Objectif : produire une traduction en français canadien de l’AMSTAR 2, en affirmer la validité de contenu et en examiner la fidélité interjuges. Méthodologie : selon une approche adaptée de celle proposée par Vallerand, des traductions directes et renversées ont été effectuées. Ensuite, en examinant les traductions, un premier comité d’experts a créé la version expérimentale préliminaire. Celle-ci a été modifiée par un deuxième comité d’experts. Vingt futurs professionnels de la santé ont évalué la nouvelle version avec une échelle d’ambiguïté (de 1 à 7). Les cochercheurs principaux ont examiné les éléments problématiques pour affermir la version préofficielle. Afin d’assurer la validité de contenu, une dernière rétrotraduction a été effectuée, validant une version officielle. Ensuite, 4 juges ont évalué 13 revues systématiques publiées en français à l’aide de la version officielle. Le coefficient kappa a été utilisé afin d’examiner la fidélité interjuges. Résultats : cette adaptation a permis la création d’une version franco-canadienne de l’AMSTAR 2. Son utilisation a démontré très peu d’ambiguïté (moyenne 1,15; ÉT 0,26) et une bonne fidélité interjuges (Kappa global > 0,64). Conclusion : la version franco-canadienne de l’AMSTAR 2 pourrait servir de soutien aux cliniciens, aux éducateurs et aux gestionnaires francophones au Canada lorsqu’ils cherchent à adopter une pratique factuelle.
THE ROLE OF HIPEC IN PERITONEAL CARCINOMATOSIS DUE TO COLORECTAL CANCER – PROCEDURE, COMPLICATIONS, AND LITERATURE EVIDENCE
Authors: Slavu Iulian , Tulin Adrian , Socea Bogdan , Păduraru Dan Nicolae , Braga Vlad , Alecu Lucian 
Published: March 2021

Cytoreductive surgery and HIPEC have become de pillars of treatment in advanced, metastatic colorectal cancer. This state of evolution of the disease was considered terminal just a few years ago. It has been demonstrated that by combining these therapies in selected patients one can increase survival time. Once this has been obtained to some length modern studies have been focused on the quality of life, safety, and how this time interval can be increased. We have reviewed the most important prospective, randomized clinical trials regarding HIPEC and peritoneal carcinomatosis. The technique, complications, principles of action, and evolution through time of HIPEC have been addressed and covered. Special consideration had been given to the correlation between the carcinomatosis index and HIPEC. HIPEC with maximal cytoreduction can be considered a curative procedure only in strictly selected patients diagnosed with colorectal cancer and peritoneal carcinomatosis. Although it has been present in the medical field for almost 30 years, it is not wide-spread due to the high costs of implementation and the requirement of highly specialized surgical and medical teams. As technology evolves, the costs can be decreased and HIPEC should be largely available in oncological centers since the foundation of implementation is solid and the fact that clear benefits although small have been demonstrated. Taking into account all of the above, HIPEC should not be considered a standard treatment at present and should only be performed in experienced centers. The correct selection of patients is critical to the success of this procedure. Maximum cytoreduction should only be performed if the carcinomatosis index allows.