bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnesium Complexes of Ladanein: A Beneficial Strategy for Stabilizing Polyphenolic Antivirals
Authors: Martin‐Benlloch Xavier , Lanfranchi Don Antoine , Haid Sibylle , Pietschmann Thomas , Davioud‐Charvet Elisabeth , Elhabiri Mourad 
Published: June 2021

AbstractLadanein (noted FOMe) is a potent antiviral flavone that was shown to be active on a broad spectrum of enveloped viruses. This 5,6,7‐trihydroxylated flavone has, however, pharmacokinetic properties and a half‐life time that need to be improved for possible therapeutic applications. We herein took advantage of the complexation properties of ladanein (Fe(III)) to evaluate its ability to bind Mg(II) (biologically relevant and redox inert ion) precursors prepared beforehand from various carboxylic acids. The 5,6,7‐trihydroxylated pattern of ladanein and the ligands borne by the Mg(II) atom of the precursors were found to be essential for firm Mg(II) binding. In particular, a ternary Mg(II) complex of ladanein and pidolate (noted FOMe.MgPid) was isolated and considered for its pharmacokinetic and virucidal (Hepatitis C Virus ‐ HCV) properties. Mg(II) complexation significantly improved the physico‐chemical (solubility) and the pharmacokinetic properties (clearance, plasmatic concentration) of the flavone FOMe, while not altering its anti‐HCV capacity.
Metal‐Catalyzed C(sp2)−H Functionalization Processes of Phenylalanine‐ and Tyrosine‐Containing Peptides
Authors: Correa Arkaitz 
Published: June 2021

AbstractThe site‐selective chemical diversification of biomolecules constitutes an unmet challenge of capital importance within medicinal chemistry and chemical biology. The functionalization of otherwise unreactive C−H bonds holds great promise for reducing the reliance on existing functional groups, thereby streamlining chemical syntheses. Over the last years, a myriad of peptide labelling techniques featuring metal‐catalyzed C−H functionalization reactions have been developed. Despite the wealth of reports in the field, the site‐selective modification of both phenylalanine (Phe) and tyrosine (Tyr) compounds upon metal catalysis remain comparatively overlooked. This review highlights these promising tagging strategies, which generally occur through the formation of challenging 6‐membered metallacycles and enable the late‐stage diversification of peptides in a tailored fashion.
Dual‐State Emissive π‐Extended Salicylaldehyde Fluorophores: Synthesis, Photophysical Properties and First‐Principle Calculations
Authors: Stoerkler Timothée , Frath Denis , Jacquemin Denis , Massue Julien , Ulrich Gilles 
Published: June 2021

AbstractThe search for simple, low‐cost, versatile, easily accessible, stimuli‐responsive, highly emissive molecular fluorophores emitting both in solution and in the solid‐state has prompted us to investigate the optical properties of a series of synthetically accessible salicylaldehyde derivatives possessing a π‐conjugated moiety at their 4‐position. These dyes are mainly known as synthetic intermediates but can also display sizeable Excited‐State Intramolecular Proton Transfer (ESIPT) fluorescence owing to the presence of a 6‐membered H‐bonded ring in their structure. The photophysical properties of these compounds have been studied in solution (multiple solvents) and in the solid‐state, as doped in PMMA films, KBr pellets or as powders leading to the observation of a pronounced fluorosolvatochromism. Emission wavelengths in the range 400–654 nm, along with photoluminescence quantum yields up to 76 % were recorded. Modification of the spacer (ethynyl, vinyl or direct connection) involved the π‐delocalization triggers major differences in terms of maximum emission wavelength and fluorescence quantum yields in the various media studied. All photophysical observations are rationalized by first‐principle calculations.
A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow
Authors: Chibwe Leah , Parrott Joanne L. , Shires Kallie , Khan Hufsa , Clarence Stacey , Lavalle Christine , Sullivan Cheryl , O'Brien Anna M. , De Silva Amila O. , Muir Derek C.G. , Rochman Chelsea M. 
Published: June 2021

Abstract
The ecological impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high-resolution liquid chromatography Orbitrap mass spectrometry to characterize the toxicity and chemical mixture of organic chemicals associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1-, 3-, and 10-d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10-d leachates, and greater toxicity in unfiltered leachates. Redundancy analysis showed that several benzothiazoles and aryl-amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2-aminobenzothiazole, 2-mercaptobenzothiazole, N,N′-diphenylguanidine, and N,N′-diphenylurea. However, many other chemicals characterized as unknowns are likely to also play a key role in the adverse effects observed. Our study provides insight into the types of chemicals likely to be important toxicological drivers in tire leachates, and improves our understanding of the ecotoxicological impacts of tire wear particles. Environ Toxicol Chem 2022;41:1144–1153. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Abstract
Redundancy analysis (RDA) shows positive correlations between chemicals benzothiazoles and aryl-amines in tire leachates, and increased hatch severity and lack of pigmentation in fathead minnow embryos. OHBT = hydroxybenzothiazole; PBI = 3-phenyl-1,3-benzothiazol-2-imine; NHBT = 2-aminobenzothiazole; MeSBT = 2-(methylthio)benzothiazole; MBT = 2-mercaptobenzothiazole; DPG = N,N′-diphenylguanidine; CPU = cyclohexyl-3-phenylurea; DHU = N,N′-dicyclohexylurea; DPU = N,N′-diphenylurea; DHPA = 4,5-diphenyl-1H-pyrazole-3-amine; DHA = dicyclohexylamine; HM = hexa(methoxymethyl)melamine; ABZ = 3-aminobenzamide; BT = benzothiazole; ACT = acetoacetanilide; TMQ = 1,2-Dihydro-2,2,4-trimethylquinoline; ACR = acridene.
Synthesis of MCM‐41 mesoporous silica nanoparticles supported titanium dioxide‐silver nanocomposite with excellent methanol electrooxidation performance
Authors: Rezvany Rozbeh , Hassaninejad‐Darzi Seyed Karim , Pourali Seyedeh Masoomeh 
Published: June 2021

AbstractConsidering the importance of the fuel cells, we developed an appropriate and efficient electrode system for electrocatalytic oxidation of methanol by fabricating the electrode with naturally based synthesized mobil composition of matter No. 41 (MCM‐41) mesoporous silica nanoparticle along with silver and titanium dioxide nanoparticles. The extracted silica from natural stem straw was applied in the synthesis of MCM‐41 mesoporous silica nanoparticle and characterization of the products was performed by different techniques. Then, the synthesized MCM‐41 mesoporous silica is modified by silver and titanium dioxide nanoparticles and is employed in the fabrication of the modified carbon paste electrodes (Ag/TiO2/MCM‐41/CPE) that are accordingly used in the electrocatalytic oxidation of methanol. The mechanistic and kinetic studies of the reactions are thoroughly examined based on cyclic voltammetry and chronoamperometry techniques. The results reveal that the modified carbon paste electrode with silver and titanium dioxide nanoparticles supported onto MCM‐41 mesoporous silica exhibit much higher current densities and less overpotentials than that at the bare carbon paste electrode. The results of the electrocatalytic oxidation of methanol are then compared to the literature indicating that the developed system is favorable for the direct methanol fuel cells.
Increased complexity of t(11;14) rearrangements in plasma cell neoplasms compared with mantle cell lymphoma
Authors: Dalland Joanna C. , Smadbeck James B. , Sharma Neeraj , Meyer Reid G. , Pearce Kathryn E. , Greipp Patricia T. , Peterson Jess F. , Kumar Shaji , Ketterling Rhett P. , King Rebecca L. , Baughn Linda B. 
Published: June 2021

AbstractPlasma cell neoplasms (PCN) and mantle cell lymphoma (MCL) can both harbor t(11;14)(q13;q32) (CCND1/IGH), usually resulting in cyclin D1 overexpression. In some cases, particularly at low levels of disease, it can be morphologically challenging to distinguish between these entities in the bone marrow (BM) since PCN with t(11;14) are often CD20‐positive with lymphoplasmacytic cytology, while MCL can rarely have plasmacytic differentiation. We compared the difference in CCND1/IGH by fluorescence in situ hybridization (FISH) in PCN and MCL to evaluate for possible differentiating characteristics. We identified 326 cases of MCL with t(11;14) and 279 cases of PCN with t(11;14) from either formalin‐fixed, paraffin‐embedded tissue or fresh BM specimens. The “typical,” balanced CCND1/IGH FISH signal pattern was defined as three total CCND1 signals, three total IGH signals, and two total fusion signals. Any deviation from the “typical” pattern was defined as an “atypical” pattern, which was further stratified into “gain of fusion” vs “complex” patterns. There was a significantly higher proportion of cases that showed an atypical FISH pattern in PCN compared with MCL (53% vs 27%, P < .0001). There was also a significantly higher proportion of cases that showed a complex FISH pattern in PCN compared with MCL (47% vs 17%, P < .0001). We confirmed these findings using mate‐pair sequencing of 25 PCN and MCL samples. PCN more often have a complex CCND1/IGH FISH pattern compared with MCL, suggesting possible differences in the genomic mechanisms underlying these rearrangements in plasma cells compared with B cells.
Understanding giant cell sarcoma of the head and neck: A population‐based study
Authors: Sawhney Rohan , Ahsanuddin Salma , Sheorey Lena , Wassef David W. , Baredes Soly , Park Richard Chan Woo 
Published: June 2021

AbstractBackgroundGiant cell sarcomas (GCS) are rare head and neck neoplasms.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.ResultsFour hundred and forty cases of GCS of the head and neck were identified. The average age at diagnosis was 74.4 years, 86.8% were white, 82.5% were male, 70.7% were insured, and 88.2% lived in an urban metropolitan region. Connective tissue was the most frequent primary site (42.5%). The 5Y‐DSS rate was 91.1%, while the 5Y‐OS was 54.6% for all cases. Patients treated with surgery alone had the highest 5Y‐DSS rate of 94.5. T‐classification odds ratio was a significant predictor of survival accounting for confounding variables on multivariate analysis.ConclusionsGCS presents most frequently in connective tissue of the head and neck with overall high probability of survival. The treatment of choice is surgery alone.
Investigating heat conduction in a sphere with heat absorption using generalized Caputo fractional derivative
Authors: Elhadedy Hager , Abdel Kader Abass H. , Abdel Latif Mohamed S. 
Published: June 2021

AbstractIn this paper, we study the ρ‐Laplace transform and the finite sin‐Fourier transform as powerful tools in solving fractional differential equations with generalized Caputo derivative. We use these transforms to solve the time‐fractional heat equation with a generalized Caputo fractional derivative associated with heat absorption in spherical coordinates. We obtain the solutions in two cases of Dirichlet boundary conditions. The effect of the parameter , which characterizes the generalized Caputo derivative is illustrated through some numerical examples.
Ecological risk assessment of the effects of neonicotinoid insecticides on northern bobwhites (Colinus virginianus) in the South Texas Plains Ecoregion
Authors: Sabin Laura Beth , Mora Miguel A. 
Published: June 2021

Abstract
Neonicotinoid insecticides are among the latest class of insecticides that can have harmful effects on birds. Approximately 30 000 kg of neonicotinoid insecticides are applied annually to 429 100 ha of row-crop fields within the South Texas Plains Ecoregion, Texas, USA. Various studies have demonstrated that treated seeds can be highly toxic to northern bobwhites, with the consumption of only 20 corn seeds causing a fatality. Similarly, other studies have indicated that neonicotinoid insecticides can reduce arthropod populations—a substantial prey base for northern bobwhites, especially during the breeding season—by approximately 60%. Our objective was to conduct an ecological risk assessment of neonicotinoid insecticides' impact on northern bobwhite (Colinus virginianus) populations in the South Texas Plains Ecoregion. We estimated that juvenile and adult northern bobwhites could intake from 7.32 to 27.0 mg/kg/day and from 10.0 to 37.5 mg/kg/day of neonicotinoid insecticides, respectively, which can cause adverse effects on growth, reproductive output, and long-term survival. Our study determined that the application of 30 000 kg of neonicotinoid insecticides annually in the South Texas Plains Ecoregion harms the region's northern bobwhite that are exposed to neonicotinoids. Integr Environ Assess Manag 2022;18:488-499. © 2021 SETAC
KEY POINTS
Approximately 30 000 kg of neonicotinoids are applied annually on row crop fields in the South Texas Plains Ecoregion, USA. Juvenile and adult northern bobwhites could intake from 7.3 to 27.1 mg/kg/day and from 10.1 to 37.6 mg/kg/day of neonicotinoids a day, respectively. Treated seeds contain a high concentration of neonicotinoids. Through the consumption of treated seeds and other contaminated food, bobwhites are expected to reach LOAEL levels for five adverse effects.
Updating Practice Recommendations: Taking Stock of 12 Years of Adolescent Literacy Research
Authors: Reynolds Dan 
Published: June 2021

AbstractThe demand for evidence to support instructional practices in education is surging. Consequently, many adolescent literacy researchers and educators take guidance from the Institute of Education Sciences (IES) Practice Guide for Adolescent Literacy (Kamil et al., 2008). The document, however, is now 12 years old, and adolescent literacy research and practice has shifted substantially. First, I document the limitations of the IES Guide’s pre‐2008 research base and of the students sampled in its underlying studies. Then, I survey research from 2008–2020 that expands on the Guide’s five recommendations, and name areas of research undeveloped in 2008 but vibrant in 2020. To illustrate the instructional implications of these changes, I present an example unit incorporating changes suggested by research since 2008. Finally, I call on adolescent literacy organizations to maintain, revise, and publish practice guidelines to ensure all our adolescents get the daily literacy instruction they deserve.
Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li2O·11.10ZrO2·69.32SiO2 glass–ceramic
Authors: Possolli Natália Morelli , da Silva Daiara Floriano , Vieira Jaqueline , Maurmann Natasha , Pranke Patricia , Demétrio Ketner Bendo , Angioletto Elidio , Montedo Oscar Rubem Klegues , Arcaro Sabrina 
Published: June 2021

AbstractGlass and bioactive glass–ceramic can be used in several applications. In bone growth where good bone/biomaterial adhesion was required, bioactive coatings for implants can improve bone formation. The glass and glass–ceramics of the LZS (Li2O‐ZrO2‐SiO2) system are very interesting because of their mechanical, electrical, and thermal properties. Very recently, their biological response in contact with human osteoblast has been evaluated. However, despite several initiatives, there are still no studies that systematically assess this system's bioactivity, dissolution, and cytotoxicity in vitro. This work aims to investigate the dissolution, bioactivity behavior, and cytotoxicity of LZS glass–ceramic. LZS glass–ceramics were produced from SiO2, Li2CO3, and ZrSiO4 by melting followed by quenching. The obtained glass frits were milled and uniaxially pressed and heat‐treated at 800 and 900°C and submitted to physical–chemical, structural and mechanical characterization. Their dissolution behavior was studied in Tris–HCl, while bioactivity was performed in simulated solution body fluid (SBF). The cytotoxicity test was performed using glass–ceramic in direct contact with mesenchymal stem/stromal cells (SC) isolated from human exfoliated deciduous teeth. Structural and microstructural analyzes confirmed bioactivity. The results show that it was possible to produce bioactive glass–ceramic from LZS, proven by the formation of new calcium phosphate structures such as hydroxyapatite on the surface of the samples after exposure to SBF. The SC viability test performed indicated that the materials were not cytotoxic at 0.25, 0.5, and 1.0 mg/ml. The glass–ceramic system under study is very promising for a medicinal application that requires bioactivity and/or biocompatibility for bone regeneration.
Engaging photovoice to complement on sexual assault climate research: A literature review, case study, and recommendations
Authors: Christensen M. Candace , Caswell Caitlin , Yilmazli Trout Inci , Tose Shaniek 
Published: June 2021

AbstractThrough the implementation of three photovoice projects, we discovered how photovoice method complements sexual assault climate survey research. Scholars have recently asserted that qualitative and participatory research methods are necessary to conduct a holistic sexual assault climate evaluation. Nevertheless, an in‐depth analysis of how photovoice complements sexual assault climate research is missing. To fill this gap, we examine photovoice studies focused on sexual assault climates, describe methods one author used to implement three photovoice projects, and demonstrate how the analysis of photovoice data generates findings distinctive from survey research. Our findings show how photovoice contextualizes and personalizes the problem, illustrates subjective and diverse standpoints, and highlight community values and norms. Specific to sexual climates the results demonstrate how society perpetuates a culture of victim‐blaming, creates barriers to help‐seeking, and how communities can support assault survivors by affirming their recovery process. We conclude the article with implications for practice and research.
The organizational trauma‐informed practices tool (O‐TIPs): Development and preliminary validation
Authors: Manian Nanmathi , Rog Debra J. , Lieberman Leslie , Kerr Eleanor M. 
Published: June 2021

AbstractThe goal of the study was to develop and validate a simple, short, easy to self‐administer, and cost‐effective tool to assess organizational trauma‐informed practices (O‐TIPs), by building on existing tools. The tool was developed through a series of steps involving detailed examination, selection, and modification of existing trauma‐informed (TI) frameworks and tools, which resulted in a 31‐item questionnaire with three domains and eight subscales. The O‐TIPs was evaluated for known‐group construct validity to determine the degree to which it could discriminate between groups of organizations that were higher and lower on the extent to which they were implementing TIPs, by administering it online to staff at seven federally qualified health centers at two‐time points. The domains, subscales, and the overall measure showed high internal consistency and discriminated significantly between known groups of centers at baseline and follow‐up. In addition, the tool captured change over time in the extent to which the organizations were implementing TIPs. These findings provide preliminary support for the future use of the O‐TIPs tool by service‐delivery organizations.
The relationship between perceived stress, uncertainty emotions and hopelessness regarding pandemics in pregnant women
Authors: Fiskin Gamze 
Published: June 2021

AbstractThe objective of this study was to determine the emotional reactions of pregnant women towards the pandemic and to increase awareness of healthcare professionals on this subject. In this descriptive, cross‐sectional, and correlational study, an online questionnaire was applied to 375 pregnant women (n = 375). Data were collected with pregnant information form, Intolerance of Uncertainty Scale and Beck Hopelessness Scale. The mean age of the pregnant women was 29.495 ± 4.301, and the mean gestational week was 27.469 ± 7.971. Pregnant women's levels of perceived stress and intolerance to uncertainty were high. There was a moderate positive correlation between stress and uncertainty levels of the women who stated that they experienced mild hopelessness. It is recommended to identify risky groups and provide the necessary psychological support by health professionals during the pandemic.
Oxidative stress in oocyte aging and female reproduction
Authors: Wang Ling , Tang Jinhua , Wang Lei , Tan Feng , Song Huibin , Zhou Jiawei , Li Fenge 
Published: June 2021

AbstractIn a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When the balance is broken toward an overabundance of ROS, oxidative stress appears and may lead to oocyte aging. Oocyte aging is mainly reflected as the gradual decrease of oocyte quantity and quality. Here, we aim to review the relationship between oxidative stress and oocyte aging. First, we introduced that the defective mitochondria, the age‐related ovarian aging, the repeated ovulation, and the high‐oxygen environment were the ovarian sources of ROS in vivo and in vitro. And we also introduced other sources of ROS accumulation in ovaries, such as overweight and unhealthy lifestyles. Then, we figured that oxidative stress may act as the “initiator” for oocyte aging and reproductive pathology, which specifically causes follicular abnormally atresia, abnormal meiosis, lower fertilization rate, delayed embryonic development, and reproductive disease, including polycystic ovary syndrome and ovary endometriosis cyst. Finally, we discussed current strategies for delaying oocyte aging. We introduced three autophagy antioxidant pathways like Beclin‐VPS34‐Atg14, adenosine 5‘‐monophosphate (AMP)‐activated protein kinase/mammalian target of rapamycin (AMPK/mTOR), and p62‐Keap1‐Nrf2. And we also describe the different antioxidants used to combat oocyte aging. In addition, the hypoxic (5% O2) culture environment for oocytes avoiding oxidative stress in vitro. So, this review not only contribute to our general understanding of oxidative stress and oocyte aging but also lay the foundations for the therapies to treat premature ovarian failure and oocyte aging in women.
Taxonomy and spore morphology of selected taxa of Cheilanthoideae and Pteridoideae (Pteridaceae) from Pakistan
Authors: Irfan Muhammad , Jan Gul , Jan Farzana Gul , Murad Waheed 
Published: June 2021

AbstractTaxonomy and spore morphology of 12 taxa of Cheilanthoideae and Pteridoideae (Pteridaceae, Polypodiales) from Pakistan is illustrated with scanning electron microscopy images based upon the specimens collected from various localities. A total of six genera belong to 12 taxa viz. Actiniopteris radiata, Aleuritopteris albomarginata, A. ancepes, Notholaena himalaica, Oeosporangium nitidulum, O. pteridioides subsp. acrosticum, Onychium cryptogrammoides subsp. cryptogrammoides, O. vermae, Pteris cretica subsp. cretica, P. cretica subsp. laeta, P. vittata subsp. emodi, and P. vittata subsp. vittata were reported. Spore morphology of the taxa was trilete, triangular in proximal and distal view, ellipsoidal and hemicircular in equatorial view, polar proximal and distal surface with cristate, granulose, reticulate, perforate and tuberculate ornamentation.