bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrophilic modification of PVDF membranes by in situ synthesis of nano-Ag with nano-ZrO2
Authors: Lu Yanjun , Ma Yuxuan , Yang Tong , Guo Jifeng 
Published: August 2021

Abstract
Modified polyvinylidene fluoride (PVDF) membranes were prepared by the phase inversion method via blending in situ formed nanosilver (Ag) and nanozirconium dioxide (ZrO2). Scanning electron microscopy of the membranes revealed that the surface pore size of the membranes was increased and distributed widely with the addition of modified nanosilver (Ag) and nanozirconium dioxide (ZrO2). The pores of the membrane were reduced due to excessive modification of the material when the content of zirconium dioxide was increased to 0.4%. XRD characterization showed that in situ synthesis of nanosilver (Ag) and nanozirconium dioxide (ZrO2) had been successfully blended in the membranes. The contact angle of the modified membrane ranged from 82.72° to 67.37°, which showed that the hydrophilic properties of the membrane were improved. The pure water flux of the modified membrane increased from 28.43 to 143.2 L/m2 h, indicating that the hydrophilicity of the modified membrane was enhanced significantly. The flux recovery rate of the modified membrane was obviously increased in the fouling experiment with BSA as the source of organic pollutants. The antimicrobial contamination of the membrane was greatly enhanced with the E. coli microbial contamination experiment.
Paracrine study of adipose tissue-derived mesenchymal stem cells (ADMSCs) in a self-assembling nano-polypeptide hydrogel environment
Authors: Ling Jianmin , Tian Ailing , Yi Xin , Sun Nianfeng 
Published: August 2021

Abstract
To research the paracrine role of adipose tissue-derived mesenchymal stem cells (ADMSCs) in promoting angiogenesis under the three-dimensional culture conditions consisting of a functionalized self-assembling peptide nanofiber hydrogel. ADMSCs were isolated, extracted, and then identified. Three kinds of peptides (RADAI-16, RGD, and KLT) were prepared, and a functionalized self-assembling peptide nanofiber hydrogel was produced by mixing RADAI-16, RGD, and KLT in a volume ratio 2:1:1. AFM was used to observe RADAI-16, RGD, KLT, and the functionalized self-assembling peptide nanofiber hydrogel. Then, ADMSCs were cultured under three-dimensional conditions consisting of the peptide nanofiber hydrogel, and AFM was used to observe cell migration. The ADMSCs in the common culture group (37°C, 5% CO2 cell culture box) and hypoxic culture group (37°C, 10% CO2, and 1% O2 hypoxic culture box) acted as controls. ADMSCs were three-dimensionally cultured in situ for 1 day, and then the concentrations of HGF and VEGF in the supernatant were determined by ELISA. Cells were extracted from the peptide nanofiber hydrogel, and HO-1 expression was detected by western blotting. ADMSCs have high expression levels of CD29, CD90, and CDl05 and low expression levels of CD34 and CD45. In addition, they can differentiate into adipocytes and osteocytes. The diameters of the fibers of RADAI-16, RGD, KLT, and the functionalized self-assembling peptide hydrogel are 17.34 ± 1.82, 15.50 ± 1.41, 13.77 ± 1.18, and 20.26 ± 1.25 nm, respectively. AFM indicated that cells in the functionalized self-assembling peptide nanofiber hydrogel migrated farther than those in RADAI-16. The concentrations of HGF under common, hypoxic, and three-dimensional culture conditions were 47.31 ± 6.75, 247.86 ± 17.59, and 297.25 ± 17.95 pg/mL, respectively, while the concentrations of VEGF were 218.30 ± 3.03, 267.13 ± 4.27, and 289.14 ± 3.11 pg/mL, respectively. Both HGF and VEGF were expressed more in the presence of the functionalized self-assembling peptide nanofiber hydrogel than in its absence (P < 0.05). Using western blotting, ADMSCs cultured under hypoxic and three-dimensional conditions were found to have high expression levels of HO-1. Culturing ADMSCs under three-dimensional conditions consisting of functionalized self-assembling peptide nanofiber hydrogels can promote their paracrine role in angiogenesis, such as HGF and VEGF, and hypoxia is one of the important elements.
Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment
Authors: Schmaul Samantha , Hanuscheck Nicholas , Bittner Stefan 
Published: August 2021

Abstract
Astrocytes are key regulators of their surroundings by receiving and integrating stimuli from their local microenvironment, thereby regulating glial and neuronal homeostasis. Cumulating evidence supports a plethora of heterogenic astrocyte subpopulations that differ morphologically and in their expression patterns of receptors, transporters and ion channels, as well as in their functional specialisation. Astrocytic heterogeneity is especially relevant under pathological conditions. In experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), morphologically distinct astrocytic subtypes were identified and could be linked to transcriptome changes during different disease stages and regions. To allow for continuous awareness of changing stimuli across age and diseases, astrocytes are equipped with a variety of receptors and ion channels allowing the precise perception of environmental cues. Recent studies implicate the diverse repertoire of astrocytic ion channels – including transient receptor potential channels, voltage-gated calcium channels, inwardly rectifying K+ channels, and two-pore domain potassium channels – in sensing the brain state in physiology, inflammation and ischemia. Here, we review current evidence regarding astrocytic potassium and calcium channels and their functional contribution in homeostasis, neuroinflammation and stroke.
Benefits and effectiveness of high pressure processing on cheese: a ricotta case study
Authors: Stefanini Roberta , Ronzano Anna , Borghesi Giulia , Vignali Giuseppe 
Published: September 2021

Abstract
Today High Pressure Processing (HPP) is receiving interest thanks to its ability to stabilize foods preserving nutritional and sensorial characteristics. This work applies HPP on nutrient ricottas created in the Parmigiano Reggiano area and demonstrates not only its benefits, but also disadvantages, testing different pressures and packaging. Moreover, the ability of HPP to prolong the lag phase and reduce the maximum growth rate of bacteria is illustrated with a mathematical model. Results show the influence of HPP parameters on microbial growth, volatile organic compounds, syneresis, softness and colour, and demonstrate that not all packaging are suitable for the treatment. Obtained data highlight the effectiveness of HPP, which results the best stabilization method to sell safe and nutritive ricottas on the market with a long shelf life. Of course, the work can be a starting point for food companies who want to test an innovative and promising non-thermal technology.
Analysis of flavor compounds in marinated chicken wings after irradiation and natural antioxidant (phytic acid and tea polyphenols) treatment
Authors: Long Mingxiu , Liu Min , Li Yongfu , Tian Zhuxi , He Yangbo , Shi Bin , Liang Qian , Tan Shuming 
Published: September 2021

Abstract
Marinated chicken wings is one of the popular marinated meat products in China. Here, electronic nose (e-nose) and solid phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) were used to detect volatile components of four different treatment marinated chicken wings (neither irradiated nor added phytic acid and tea polyphenols, A1; added phytic acid and tea polyphenols but no irradiated, A2; irradiated with 4 kGy irradiation but not added phytic acid and tea polyphenols, A3; irradiated with 4 kGy irradiation and added phytic acid and tea polyphenols, A4). Then odor activity value (OAV) and principal component analysis (PCA) were utilized to analyze their key flavor compounds. E-nose analysis found that antioxidant has a great impact on the odor of the marinated chicken wings, while the irradiation treatment has little effect on it. Besides, the irradiation treatment can reduce the unpleasant odor caused by antioxidants in certain. Through SPME-GC-MS, 101 volatile compounds were identified in four groups. After analysis, the antioxidants can inhibit the production of some volatile compounds, while irradiation treatment will relieve this phenomenon. This result is consistent with the e-nose. Following OAV, PCA analysis and sensory evaluation further verified the above conclusions.
Deployment of the formulaic utterance “how about∼” in task-based second language classroom discussions
Authors: Aline David , Hosoda Yuri 
Published: August 2021

AbstractFormulaic speech has long been of interest in studies of second language learning and pragmatic use as production and comprehension of formulaic utterances requires less processing and production effort and, therefore, allows for greater fluency. This study scrutinizes the sequential positions and actions of one formulaic utterance “how about∼” from the participants’ perspective. This conversation analytic study offers a fine-grained microanalysis of student interaction during classroom peer discussion activities. The data consist of over 54 h of video-recorded classroom interaction. Analysis revealed several positions and actions of “how about∼” as it occurs during peer discussions by Japanese learners of English. Emerging from analysis was a focus on how learners deploy this formulaic utterance to achieve various actions within sequences of interaction. Analysis revealed that participants used “how about∼” for (a) explicitly selecting next speaker, (b) shifting topics, (c) proposing a solution, and (d) suggesting alternative procedures. Although the formula was deployed to perform these four different actions, consistent throughout all instances was the disclosure of learner orientation to the progressivity of the task interaction. The findings show how language learners deploy this formulaic utterance in discussion tasks designed for language learning and highlights the pragmatic functions of this phrase.
The status of conventional metaphorical meaning in the L2 lexicon
Authors: Werkmann Horvat Ana , Bolognesi Marianna , Kohl Katrin 
Published: August 2021

AbstractThis paper investigates how L2 speakers of English process conventional metaphorical expressions. While much of the literature on L2 processing of figurative expressions focuses on idioms only, the aim of this paper is to investigate how L2 speakers process conventional metaphorical expressions. The results of a cross-modal semantic priming task show that conventional metaphors have a special status in comparison to literal language in the L2 lexicon. The differences in reaction times show that L2 speakers are aware of the connections between literal primes and targets, resulting in slower reaction times, while this effect is not found in the metaphorical condition. This demonstrates that even when metaphorical language is very conventional, it can cause difficulties for L2 speakers. Furthermore, these results show that conventional metaphorical expressions can pose a semantic and pragmatic challenge for language learners, thus creating a need for explicit teaching of metaphorical meanings of polysemous words.
Populist discourse and active metaphors in the 2016 US presidential elections
Authors: Keating John 
Published: August 2021

Abstract
In recent years, the specter of populism has grown increasingly restless in the Western world and beyond. This new populism has been observed in different political movements in Europe; the Brexit movement in the UK, Podemos and Vox in Spain, Rassemblement National in France, Partij voor de Vrijheid in the Netherlands, and Viktor Orbán’s illiberal democracy in Hungary. Inevitably, it is most commonly associated with the election of Donald Trump as president of the USA in 2016. In this paper, a pragmatic interaction theory of metaphorical utterances is applied to a corpus of speeches given by candidates during the American 2016 presidential elections. First, speeches and candidates were graded for populism according to a holistic grading method. Secondly, speeches were analyzed using quantitative and qualitative methods to investigate if and how active metaphorical language was used to construct the populist frame. The findings suggest that active metaphors can be useful for politicians who wish to counter the dominant conventional frames, and so can serve the ideological purposes of populists and non-populists alike. Therefore, this paper also argues that novel metaphorical concepts and active metaphorical utterances make important contributions to the communication of ideologies in political discourse and should not be overlooked by analysts.
The Hermit Kingdom’s Forgotten Threat: Evaluating UNSCR 1540’s Effectiveness in Controlling North Korea’s Biological Weapons Program
Authors: Reynolds Jakob 
Published: August 2021

Abstract
Mitigating the proliferation of biological weapons remains uniquely challenging, even 48 years after the ratification of the Biological Weapons Convention (BWC). Suspected development of advanced biological weapons by the Democratic People’s Republic of Korea (North Korea), despite its status as a party to both the BWC and other nonproliferation agreements, has emphasized the need for international efforts to keep biological weapons out of the hands of rogue nations and terrorist networks. Among the numerous weaponized cultures believed to be in development by the North Korean military are anthrax, botulism, cholera, plague and smallpox. With a steady decrease in resources and attention devoted to preparedness for biological attacks or outbreaks since 2001, the United States and its allies remain vulnerable to biological weapons in development by North Korea. An ongoing example of this danger is demonstrated by the international community’s struggle to respond to the coronavirus disease 2019 (COVID-19) pandemic. With United Nations Security Council Resolution (UNSCR) 1540’s expiration in 2021, this paper aims to assess its effectiveness in preventing the proliferation of biological weapons by analyzing the legal requirements UNSCR 1540 imposes on UN member nations. Using North Korea’s biological weapons program as a case study, this paper will evaluate the successes and failures of UNSCR 1540’s legal mechanisms in controlling biological weapons development in North Korea in its penultimate year of validity. This paper will also examine the overlapping roles served by the World Health Organization (WHO), the Biological Weapons Convention (BWC), and UNSCR 1540, and how their administrative frameworks identify and respond to natural disease outbreaks and biological attacks. Finally, this paper will recommend actions the United Nations Security Council may take to more effectively pursue its mission of nonproliferation.
The effect of aromatherapy with rose essential oil on apparent anxiety in patients with myocardial infarction
Authors: Haddadi Mohammad , Robat Sarpooshi Hamid , Jaghouri Elaheh , Dehnabi Alemeh 
Published: August 2021

Abstract

Objectives
Acute myocardial infarction (MI) and hospitalization are one of the most stressful situations for many patients. Aromatherapy is a branch of the complementary medicine that is effective in anxiety. The present study aims to determine the effect of aromatherapy with rose essential oil (REO) on apparent anxiety in patients with acute MI.

Methods
This randomized clinical trial was carried out on patients with acute MI admitted to the cardiac ward of Heshmatieh Hospital in Sabzevar. Eighty patients were randomly assigned to two aromas and placebo groups, who received three drops of REO or placebo by inhalation three times a day for 3 days. Before and after the intervention, patients’ anxiety levels were measured by the Spielberger questionnaire. Data were analyzed by chi-square and the independent and paired and t-tests.

Results
Before the intervention, the mean of apparent anxiety was not significantly different in the intervention and control groups (48.44 ± 3.81 and 51.38 ± 7.21, respectively, p=0.16) while this parameter was significant after the intervention in both experimental groups (47.27 ± 7.11 and 44.16 ± 4.63, respectively, p=0.000), with a reduction in the mean of apparent anxiety in the intervention group. Moreover, the results of paired t-test revealed that the anxiety scores decreased significantly in the test group before and after the intervention (51.38 ± 7.21 and 44.16 ± 4.63, p=0.000).

Conclusions
Considering the positive effects of REO used in this study to reduce anxiety in patients with acute MI, the use of REO is recommended as a complementary treatment to reduce anxiety in these patients.
Efficacy of lettuce seed syrup on insomnia in patients with breast cancer: a pilot double blind randomized placebo controlled clinical trial
Authors: Mosavat Seyed Hamdollah , Mirzaei Hamid Reza , Mofid Bahram , Gharehgozlou Reyhaneh , Parvizi Mohammad Mahdi , Bradley Ryan , Pasalar Mehdi , Heydarirad Ghazaleh 
Published: August 2021

Abstract

Objectives
Insomnia and sleep disorders are common and can be severe amongst patients with cancer, especially during chemotherapy. The aim of this study was to evaluate the efficacy of lettuce seed syrup in breast cancer patients who suffer from insomnia or disordered sleep.

Methods
This pilot study was a double-blinded randomized controlled clinical trial conducted in Shoha-e-Tajrish Hospital (Tehran, Iran) from September 2018 to June 2019. 50 adult patients with breast cancer with insomnia or sleep disorders were enrolled. Participants were randomly allocated to lettuce seed syrup (5 mL twice daily), or placebo syrup at the same dose for four weeks. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality before and after the intervention.

Results
Compared to placebo, the mean of the total PSQI score decreased significantly in participants who received lettuce seed syrup (p=0.014). In addition, there were statistically significant reductions in the mean scores of subject quality sleep (p=0.002), sleep duration (p=0.038), habitual sleep efficacy (p=0.029) and sleep disturbance (p=0.032) in patients who received lettuce seed syrup.

Conclusions
Lettuce seed syrup may improve self-reported sleep quality in participants with breast cancer. Larger trials are indicated in diverse samples of participants with caner to learn if these finds are generalizable.
Bioethics, Rent-Seeking, and Death: Examining the Opposition to Kidney Markets
Authors: Lemennicier Bertrand , Wenzel Nikolai G. 
Published: August 2021

AbstractThe market for kidneys offers a case study of Baptists and Bootleggers. In almost every country, sales are currently illegal and donated organs are allocated by a central planner. Thousands of people die every year, because of the shortage caused by the absence of markets. This paper starts by examining the free-market alternative, and shows that a market would solve the shortage (and thus unnecessary deaths). It then uses gains-from-trade analysis to explain why current vested interests oppose a move to a market, despite the immense potential for saved lives. In a shift to a market, gains from trade would be distributed away from lucky patients (who receive a zero-price kidney) and various industries that benefit from the shortage (dialysis, medical equipment, etc.); these “Bootleggers” form an alliance with “Baptists” (altruistic donors, large segments of the bioethics community, and organ allocation central planners).
The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar
Authors: Haris Basma , Abdellatief Ahmed , Afyouni Houda , Abdel-Karim Tasneem , Mohammed Shayma , Khalifa Amel , Al-Maadheed Maryam , Zyoud Mahmoud , Elawwa Ahmed , Al-Khalaf Fawziya , Petrovski Goran , Hussain Khalid 
Published: August 2021

Abstract

Objectives
Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar.

Methods
All children (aged 0–18 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD. Measurement of tissue transglutaminase IgA and IgG as well as anti-endomysial antibody, was done, clinical details about the birth history, family history of diabetes and CD, age of onset, and ethnicity were collected.

Results
Out of the 1,325 children with antibody positive type 1 diabetes, 54 were identified to have CD on screening and then confirmed on small bowel biopsy. The prevalence of CD in the type 1 diabetes childhood population in Qatar is 4.07%. CD and type 1 diabetes were more prevalent in the Qatari children (n=32) as compared to non-Qatari (n=22) and occurred mostly in the age group 6–10 years. The most common type 1 diabetes antibodies in children with CD were glutamic acid decarboxylase and insulin autoantibody. Twelve subjects were asymptomatic for CD symptoms and picked up only on screening.

Conclusions
The prevalence of CD in children with type 1 diabetes in Qatar is comparable to reports from around the world. Many children were asymptomatic and thus routine screening is recommended.
Estimating player value in American football using plus–minus models
Authors: Sabin R. Paul 
Published: August 2021

Abstract
Calculating the value of football player’s on-field performance has been limited to scouting methods while data-driven methods are mostly limited to quarterbacks. A popular method to calculate player value in other sports are Adjusted Plus–Minus (APM) and Regularized Adjusted Plus–Minus (RAPM) models. These models have been used in other sports, most notably basketball (Rosenbaum, D. T. 2004. Measuring How NBA Players Help Their Teams Win. http://www.82games.com/comm30.htm#_ftn1; Kubatko, J., D. Oliver, K. Pelton, and D. T. Rosenbaum. 2007. “A Starting Point for Analyzing Basketball Statistics.” Journal of Quantitative Analysis in Sports 3 (3); Winston, W. 2009. Player and Lineup Analysis in the NBA. Cambridge, Massachusetts; Sill, J. 2010. “Improved NBA Adjusted +/− Using Regularization and Out-Of-Sample Testing.” In Proceedings of the 2010 MIT Sloan Sports Analytics Conference) to estimate each player’s value by accounting for those in the game at the same time. Football is less amenable to APM models due to its few scoring events, few lineup changes, restrictive positioning, and small quantity of games relative to the number of teams. More recent methods have found ways to incorporate plus–minus models in other sports such as Hockey (Macdonald, B. 2011. “A Regression-Based Adjusted Plus-Minus Statistic for NHL players.” Journal of Quantitative Analysis in Sports 7 (3)) and Soccer (Schultze, S. R., and C.-M. Wellbrock. 2018. “A Weighted Plus/Minus Metric for Individual Soccer Player Performance.” Journal of Sports Analytics 4 (2): 121–31 and Matano, F., L. F. Richardson, T. Pospisil, C. Eubanks, and J. Qin (2018). Augmenting Adjusted Plus-Minus in Soccer with Fifa Ratings. arXiv preprint arXiv:1810.08032). These models are useful in coming up with results-oriented estimation of each player’s value. In American football, many positions such as offensive lineman have no recorded statistics which hinders the ability to estimate a player’s value. I provide a fully hierarchical Bayesian plus–minus (HBPM) model framework that extends RAPM to include position-specific penalization that solves many of the shortcomings of APM and RAPM models in American football. Cross-validated results show the HBPM to be more predictive out of sample than RAPM or APM models. Results for the HBPM models are provided for both Collegiate and NFL football players as well as deeper insights into positional value and position-specific age curves.