bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Design of a Novel Candidate Multi-Epitope Vaccine to Boost Immune Responses against SARS‐COV‐2
Authors: Mohammadi Shiva , Pour Soudabe Kavusi , Barazesh Mahdi , Bahrami Yadollah , Jalili Sajad 
Published: October 2021

Background:
The fast development of an effective vaccine is the major demand for protection against the SARS-COV-2 virus outbreak. Immuno-informatics tools are time-saving and cost-effective methods to hasten the design and establishment of a proficient multi-peptide candidate vaccine. The utilization of multi-epitope-based vaccines has demonstrated to be a promising immunization approach against viruses due to the induction of long-term protective immunity.

Method:
In the present study, a complete computational approach was conducted to design a multi-epitope-based vaccine composed of cytotoxic T lymphocyte and helper T lymphocyte epitopes of Spike and Nucleocapsid proteins conserved regions. The potential viral peptides as the candidate vaccine were screened regarding convenient features like hydrophilicity, flexibility, antigenicity, and charged properties. In the next step, the vaccine efficacy needed to be improved by an immune adjuvant. For this purpose, the C-terminal domain of heat shock protein gp96 (CT-GP96) was applied as a potent adjuvant for enhancing immunity. The final assembled construct was fused with the assistance of suitable linkers and cloned in a pET28a expression vector for overproduction of the vaccine in a bacterial host.

Result:
Following validation of the final construct in terms of its efficacy, stability, and exposure ability, molecular docking analysis was carried out to reveal its interaction with toll-like receptor 4, which is required to trigger the immune response. The molecular simulations by iMODS software confirmed the stability of the binding interface. Additionally, the computational cloning of the assembled vaccine in pET28a plasmid showed the possibility of producing a vaccine construct post-transformation in an E. coli host.

Conclusion:
The computational analysis indicated that this construct could be a potent prophylactic and therapeutic multi-epitope vaccine candidate against SARS‐COV‐2 once its effectiveness is verified by experimental and animal studies.
An mHealth App to Support Fertility Patients Navigating the World of Infertility (Infotility): Development and Usability Study
Authors: Kruglova Katya , O'Connell Siobhan Bernadette Laura , Dawadi Shrinkhala , Gelgoot Eden Noah , Miner Skye A , Robins Stephanie , Schinazi Joy , Zelkowitz Phyllis 
Published: October 2021

Background
The experience of infertility and its treatment engenders considerable stress and is often described as an emotional rollercoaster. A mobile health (mHealth) app may be a novel solution to address the psychoeducational and psychosocial support needs of fertility patients because of its potential to reduce stress and increase patient empowerment. There are a few fertility-related apps that provide information and support to both men and women undergoing fertility treatment; however, none have documented their development and evaluation process.

Objective
This study aims to describe the development and evaluation process of a bilingual mHealth app, Infotility, designed to meet the psychoeducational and psychosocial support needs of men and women undergoing fertility treatment.

Methods
To develop the Infotility app, we adhered to the Medical Research Council guidelines for the development and evaluation of complex interventions. First, we conducted literature reviews and needs assessment surveys of fertility patients and health care providers who informed the content and design of the app. Second, we tested the intervention with a small group of end users who provided feedback on the design and appropriateness of the app’s content. Third, we evaluated the uptake and usability of the app using a pre-post study design. Finally, we updated the app’s content based on participants’ feedback and searched for partners to disseminate the app to the broader public.

Results
This study is the first to describe the development and evaluation process of an mHealth app for men and women undergoing fertility treatment. The app met its goal in providing fertility patients with a clinician-approved, portable resource for reliable information about medical and psychosocial aspects of infertility and its treatments and a confidential peer support forum monitored by trained peer supporters. Participants rated the engagement, functionality, information, and esthetics of the app positively, with an overall app quality mean score of 3.75 (SD 0.53) and a star rating of 3.43 (SD 0.75), with a total possible score and star rating of 5.00.

Conclusions
By documenting the systematic development and evaluation of the mHealth app for men and women undergoing fertility treatment, this paper can facilitate the replication of the study intervention and the development of similar mHealth apps.
Cytochrome P450 1B1 Overexpression in Cervical Cancers: Cross-sectional Study
Authors: Alshammari Fatemah O F O , Al-saraireh Yousef M , Youssef Ahmed M M , Al-Sarayra Yahya M , Alrawashdeh Hamzeh Mohammad 
Published: October 2021

Background
Current standard treatments for patients with recurrent cervical cancer are not very effective and are associated with severe toxicity. Recently, the rational approach for the discovery of new therapies for cervical cancer is based on the alterations in the molecular biology of cancer cells. One of the emerging molecular changes in cancer cells is the aberrant expression of cytochrome P450 1B1 (CYP1B1). This unique enzyme has been reported to be selectively overexpressed in several cancers.

Objective
The aim of this study was to examine CYP1B1 expression in cervical cancers and to assess the enzyme’s relationship with several clinicopathological features.

Methods
Immunohistochemistry was performed to examine CYP1B1 expression in 100 patient samples with cervical cancer and 10 patient samples with normal healthy cervical tissues.

Results
CYP1B1 was expressed in the majority of the cervical cancer samples (91/100, 91.0%) but not in normal healthy cervical samples. The difference in the expression of CYP1B1 between healthy and tumorous cervical tissues was significant (P=.01). Moreover, the frequency of CYP1B1 expression was found to be significantly higher in patients with advanced grades of the disease (P=.03) and in patients having metastasis to the lymph nodes (P=.01). Surprisingly, there was a significantly higher expression of CYP1B1 in patients with a high prevalence of human papilloma virus 16/18 (P=.04).

Conclusions
The differential profile of CYP1B1 expression between cervical cancer tissues and normal cervical tissues suggests that CYP1B1 may be used as a target for future therapeutic exploitations.
Facebook Support Groups for Pediatric Rare Diseases: Cross-Sectional Study to Investigate Opportunities, Limitations, and Privacy Concerns
Authors: Titgemeyer Sarah Catrin , Schaaf Christian P 
Published: October 2021

Background
Because of the nature of rare diseases with affected individuals being widely geographically dispersed, finding an in-person/offline support group itself can be a challenge. Affected individuals therefore turn to social networking platforms such as Facebook for online support groups.

Objective
We aim to put into perspective the opportunities Facebook offers as a tool for pediatric rare disease support groups by investigating its use, advantages, and limitations including privacy concerns. We analyze group accessibility and usage, advantages specific to rare diseases, perceived privacy, and views on using Facebook for communication between health professionals and parents, pharmaceutical companies, and study recruitment.

Methods
We contacted 12 Facebook support groups for 12 respective rare diseases with pediatric onset and invited group members to participate in a cross-sectional online survey.

Results
Of 231 respondents, 87.0% (n=201) of respondents were female, 12.6% (n=29) were male, and 0.4% reported another sex (n=1). Respondents’ mean age was 41.56 years (SD 9.375); 91.3% (n=211) of respondents were parents (183 mothers, 27 fathers, 1 other sex); 59.7% (n=138) reported a self-initiated search for the Facebook group, 24.2% (n=56) received recommendations from their health professionals, and 12.6% (n=29) recommendations from someone else affected by the disease. On average, support group members visited Facebook at least once a day, visited and passively participated (read/liked posts) several times a week, and participated actively (commented/posted) once a month. As much as 79.2% (183/231) agreed that they would like to have health professionals as members of the respective Facebook group. Group members expressed more concern about privacy issues on Facebook in general than in their respective Facebook support groups, with concerns mostly related to Facebook itself and nongroup members.

Conclusions
Our study confirmed that Facebook enhances support group accessibility for parents of children with rare diseases. Group participants perceive a reduction and elimination of distance, a common challenge in rare disease, and Facebook support groups create an environment of perceived privacy. The group’s privacy setting can be a critical factor for active support group participation. Sharing personal information and pictures on Facebook is very common among group participants, which shows the importance of discussing and protecting children’s privacy rights in this context.

Trial Registration
German Clinical Trials Register DRKS00016067; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00016067
Creating Space Where Music can Happen
Authors: Holub Mark 
Published: October 2021

This article examines the role of pre-composed musical material as the basis of a band’s output, from the perspective of composer-bandleaders who direct ensembles of improvising musicians. The article proposes five distinct methods by which composer-bandleaders can navigate the ‘space’ of their band’s output and musical direction. The categories are described originally as follows: Setting a Mood, Call to Arms, Bookend, Elements in Free, Composition as Destination. These proposed methods -— or approaches -— are discovered through the analysis of existing recorded materials and reflection on practice.
Oral budesonide is an effective alternative to prednisone for treatment of autoimmune hepatitis
Authors: Anilovich Natanie J. 
Published: October 2021

A clinical decision report using:
Manns MP, Woynarowski M, Kreisel W, et al. Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. Gastroenterology. 2010;139(4):1198-1206. https://doi.org/10.1053/j.gastro.2010.06.046
for a patient with autoimmune hepatitis developing septic arthritis secondary to prednisone therapy.
Metformin monotherapy is an effective alternative for management of gestational diabetes mellitus in patients refusing insulin monotherapy
Authors: Russeth Tyler 
Published: October 2021

A clinical decision report using:
Ghomian N, Vahed SHM, Firouz S, Yaghoubi MA, Mohebbi M, Sahebkar A. The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial. J Cell Physiol. 2019;234(4):4695-4701. https://doi.org/10.1002/jcp.27238
for a patient with gestational diabetes mellitus (GDM) who does not wish to undergo insulin monotherapy.
Does HIV status confer a higher risk of acquiring COVID-19? Using Clinical Decision Science to combat patients’ anxiety
Authors: Guzman Camilo 
Published: October 2021

A clinical decision report using:
del Amo J, Polo R, Moreno S, et al. Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy. Annals of Internal Medicine. 2020;173(7):536-541. https://doi.org/10.7326/m20-3689
for a patient with HIV and concerns about COVID-19 for immunocompromised individuals.
Peritoneal dialysis vs. hemodialysis: The choice of modality of dialysis may drastically affect the quality of life of patients initiating dialysis
Authors: Daryani Deepa 
Published: October 2021

A clinical decision report using
Jung HY, Jeon Y, Park Y, et al. Better Quality of Life of Peritoneal Dialysis compared to Hemodialysis over a Two-year Period after Dialysis Initiation. Sci Rep. Jul 16 2019;9(1):10266. https://doi.org/10.1038/s41598-019-46744-1
for a young patient initiating dialysis.
Lifestyle intervention is superior to metformin in prevention of microvascular complications of diabetes in women, but socioeconomic barriers may lead to use of combination
Authors: Alaga Katanya C. , Haddad Jesse 
Published: October 2021

A clinical decision report using:
Diabetes Prevention Program Research Group. Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: The Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015;3(11):866-875. https://doi.org/10.1016/S2213-8587(15)00291-0
for a patient with pre-diabetes who is concerned about the prevention of microvascular complications through lifestyle intervention while managing her busy schedule as a traveling house cleaner.
Implementation of high intensity interval training offers opportunity to enhance glycemic control in patients with type 2 diabetes
Authors: Lau Emily 
Published: October 2021

A clinical decision report using:
Alvarez C, Ramirez-Campillo R, Martinez-Salazar C, et al. Low-Volume High-Intensity Interval Training as a Therapy for Type 2 Diabetes. Int J Sports Med. 2016;37(9):723-729. https://doi.org//10.1055/s-0042-104935
for a patient with newly diagnosed diabetes mellitus type 2.
Aplicación del SMED en la industria: Revisión sistemática de la literatura a través de VOSviewer
Authors: Ospina López Diana Yomali , VILLANUEVA MATEUS TATIANA ANDREA , Ovalle Castiblanco Alex Mauricio 
Published: October 2021

En la actualidad, el análisis bibliométrico juega un papel fundamental en la búsqueda de métodos cuantitativos para identificar las tendencias e impacto a nivel científico de campos de investigación. Este análisis, se realizó para la herramienta SMED (Single Minute Exchange of Die) en el sector industrial identificando mapas de red de co-ocurrencia, co-citación y co-autoría de palabras claves, autores y países, respectivamente en el software bibliográfico conocido como VOSviewer. El presente documento tiene por objeto implementar un análisis bibliométrico a través de la literatura para conocer las características e impacto en el paso del tiempo del SMED. Para la ejecución del documento, se ha tenido en cuenta una ecuación de búsqueda en la base de datos de Scopus, encontrándose 433 artículos relacionados con el SMED en sectores industriales. Con este fin, la herramienta puede ser aplicada en el sector automotriz, textil y metalmecánico tanto en líneas de producción como en máquinas y los países que lideran la producción científica son India, China y Estados Unidos; en contraste, no se ha identificado producción científica en Colombia. Finalmente, las organizaciones del sector industrial requieren de la herramienta SMED que permitan reducir costos y a la vez, aumentar la productividad en un proceso de cambio de herramentales.
Distributed cognitive activity as the basis of digital intellectual production: possibilities of hypertext interpretation
Authors: Nikolaeva Evgeniya Mikhailovna , Kotliar Polina Sergeevna 
Published: October 2021

The analysis of the key agents for the formation of patriotic practices in youth and the nature of their influence on young people as subjects of patriotic activity is of considerable interest to sociological science and practice which determines the purpose of this work in the specified format. The methodological basis of the study is formed by the provisions of the activity paradigm, The article also uses the results of a large-scale sociological survey conducted as part of the research project “Civic patriotism in the formation and development of solidaristic practices in the south of Russia: resource potential and conditions for its implementation”. The study concludes that one of the reasons for little involvement of south-Russian youth in patriotic activity is that the patriotic ideas translated at the level of patriotic value formation by such agents as family, educational institutions, government agencies, and the media diverge from the youth’s orientation on the content of patriotic practices involving different agents and institutes.
Waktu Kontak Ozon Dalam Penurunan Angka Lempeng Total Bakteri (Alt) Pada Alat Makan Di Kantin Pt. X Textile Cimahi
Authors: Kamaludin Ade , Hanurawaty Neneng Yetty , Septiati Yosephina Ardiani 
Published: October 2021

Ozon merupakan sebuah molekul gas yang terdiri dari tiga buah atom oksigen. Ozon merupakan gas yang tak hampir tidak larut dalam air (0,03 mg/100ml) pada suhu 20oC, berdekomposisi menjadi oksigen dalam waktu singkat, dan efektif dalam pendispersian untuk aktivitas anti mikroba.2 Alat makan yang disediakan oleh PT. X Textile Cimahi berupa piring. Hasil pemeriksaan laboratorium, didapatkan hasil pemeriksaan angka lempeng total bakteri pada alat makan piring pertama dan keduan yaitu 18 dan 21 koloni/cm2 luas permukaan alat makan. Jenis penelitian adalah eksperimen. Desain penelitian dalam penelitian ini adalah posttest with control. Rata-rata bakteri pada kontrol adalah 3813 koloni/cm2 luas permukaan alat makan, rata-rata bakteri pada perlakuan waktu kontak 10 menit adalah 8 koloni/cm2 luas permukaan alat makan, dan 2 koloni/cm2 luas permukaan alat makan pada perlakuan waktu kontak 15 menit. Produktivitas generator ozon dengan waktu 15 menit adalah 0,012 g/jam dan selama 10 menit, yaitu 0,012 – 0,013 g/jam. Pemeriksaan residu ozon pada piring selama 10 menit dan 15 menit adalah 0 ppm. Uji non-parametrik menggunakan uji wilcoxon. Nilai signifikasi (P value) bernilai 0,029 < dari 0,05 sehingga H0 ditolak yang artinya terdapat hubungan perbedaan waktu kontak ozon selama 10 menit dan perlakuan 15 menit. Waktu yang paling efektif adalah 15 menit. Saran peneliti adalah konsentrasi ozon 0,4 mg/l atau 0,4 ppm, untuk penelitian lebih lanjut disarankan konsentrasi ozon dapat ditingkatkan kembali lebih dari 0,4 ppm, namun harus memperhatikan toksisitas ozon.
Экономическая безопасность муниципального образования
Authors: Джамалудинова Мадинат Юнускадиевна , Асриянц Каринэ Геннадьевна 
Published: October 2021

Цель работы. В статье рассматриваются особенности обеспечения экономической безопасности муниципального образования. Методология проведения работы. Проведен анализ внешних и внутренних угроз экономической безопасности муниципального образования. Результаты работы. В статье дано определение экономической безопасности и экономической безопасности муниципального образования. Описаны внешние и внутренние угрозы экономической безопасности муниципального образования. Рассмотрены методы оценки экономической безопасности муниципального образования, а также возможности ее обеспечения посредством взаимного контроля основных служб. Область применения результатов – возможность применения разработанной методики в Республике Дагестан и в целом по России. Выводы. Муниципальный уровень является самым гибким и подвижным, способным адаптироваться к изменчивой внешней среде. Поэтому в развитии и укреплении экономической безопасности России в целом ставку необходимо делать именно на активизацию деятельности в муниципальных образованиях.
САНКЦИОННАЯ ПОЛИТИКА ЗАРУБЕЖНЫХ СТРАН И ЕЕ ВЛИЯНИЕ НА РАЗВИТИЕ НЕФТЯНОГО СЕКТОРА РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Селин Игорь Владимирович , Ульченко Михаил Васильевич 
Published: October 2021

Цель работы. Цель работы – изучение влияния санкционной политики зарубежных стран на российский нефтяной сектор и экономику страны в целом. Метод или методология проведения работы. При написании настоящей статьи авторами были использованы инструменты, современные методы и формы экономического анализа. Основой для проведения исследования послужили научные статьи, нормативно-правовые акты, а также официальные статистические данные. Проведенный анализ позволил определить основную группу санкций, оказывающих негативное влияние на работу предприятий нефтегазового сектора и экономику РФ в целом. Результаты. На основании проведенного анализа санкционной политики зарубежных стран и ее влияния на развитие нефтяного сектора Российской Федерации было определено, что: – искусственное снижение цен на нефть, к которому прибегают США и Саудовская Аравия, направлено на обесценивание национальной валюты и замедление темпов роста экономики РФ; – санкции, введенные в отношении отечественных нефтегазовых компаний, лишают их возможности приобретать новейшие технологии, позволяющие осуществлять добычу нефти и газа с минимальными затратами, в том числе и в сложных природно-климатических условиях Севера и Арктики, где сосредоточены основные запасы углеводородов. Возможным выходом из сложившейся ситуации является закупка норвежского высокотехнологичного оборудования через нефтегазодобывающие компании дружественных нам стран (Азербайджан, Вьетнам и др.), что, согласно международному праву, не является промышленным шпионажем; – для успешной и оперативной реализации проекта «Северный поток – 2» необходимо использовать помощь дружественно настроенных стран, входящих в состав Европейского союза (Сербия, Болгария), а также, еще больше заинтересовать финансово партнеров по проекту – Австрию и Германию; – хеджирование бюджетов регионов – распространенная зарубежная практика, позволяет не только реализовать все запланированные проекты, снижая социальную напряженность, но и способствует развитию фондового рынка. Выводы. Сделан вывод о том, что санкции – это реальность, бороться с ними сложно, но научиться жить можно. Возможным выходом из сложившейся ситуации, когда отечественные нефтегазовые компании лишены возможности приобретать новейшие технологии, является закупка норвежского высокотехнологичного оборудования через нефтегазодобывающие компании дружественных нам стран (Азербайджан, Вьетнам и др.), что, согласно международному праву, не является промышленным шпионажем.
СБАЛАНСИРОВАННАЯ СИСТЕМА ПОКАЗАТЕЛЕЙ КАК МЕТОДОЛОГИЧЕСКИЙ ИНСТРУМЕНТ ИССЛЕДОВАНИЯ ТОРГОВОЙ СЕТИ
Authors: Хусаинов Манон Камарович , Арипов Орифходжа Хабибуллоевич 
Published: October 2021

Предмет. В статье сбалансированная система показателей (ССП) рассматривается как методологический инструмент исследования торговой сети, представленный такими составляющими, как финансы, бизнес-процессы, маркетинговая деятельность и персонал. Цель работы. В настоящее время одним из прогрессивных методов исследования социальных систем, а возможно, и самых удачных и продуктивных, является теория сбалансированной системы показателей, обеспечивающей равновесие как в статике, так и в динамике между составными частями, блоками и подсистемами организаций, позиционируемыми нами в качестве системы, обладающей прямыми и обратными связями между своими составляющими. Задачи. Исследовать сбалансированную систему показателей как методологический инструмент исследования торговой сети. Методология исследования. В процессе исследования использованы методы эволюционно-институциональной теории, системного анализа и аналитической оценки. Результаты исследования. Разработка сбалансированной системы показателей требует установления связей между всеми уровнями иерархии, начиная от высшего управленческого звена, посредством выстраивания соответствующих целей и показателей развития торговой сети. Выводы. На вопрос о том, каково должно быть оптимальное число параметров, конкретного ответа не существует. С одной стороны, параметры призваны отражать все стороны деятельности организации и внутренние процессы, с другой – избыточная детализация способна препятствовать выявлению ключевых факторов успеха. Область применения результатов. Результаты исследования могут быть использованы органами власти России для ликвидации существующих проблем в области исследования торговой сети.