bluuebunny/crossref_metadata_2025_split huggingface dataset:
Être issu·e·s du même don : partager des
« origines » en assistance médicale à la procréation avec tiers donneur
(Royaume-Uni, France)
Authors: Martin Anaïs 
Published: October 2021

Cadre de la recherche : De nouvelles
figures émergent au sein des liens créés par l’assistance médicale à la
procréation avec tiers donneur : les personnes issues du même don.
Objectifs : À partir d’une enquête
anthropologique auprès d’adultes conçu·e·s par don de sperme au Royaume-Uni et
en France, l’article déploie une analyse des distinctions qui sont opérées entre
personnes issues du même don, frères et sœurs et enfants du donneur afin de
mieux comprendre ce qu’engage le partage d’» origines » quand on a été conçu·e
grâce au même donneur.
Méthodologie : L’analyse repose sur les
entretiens semi-directifs approfondis menés entre octobre 2017 et décembre 2019
avec 17 adultes conçus par don de sperme qui ont identifié au moins une personne
conçue grâce au même donneur au Royaume-Uni et en France.
Résultats : À l’aune des relations avec
les frères et sœurs, les connexions entre personnes issues du même don
apparaissent d’abord comme un lien corporel paradoxal qui se matérialise par un
partage de gènes entre des inconnu·e·s. Les distinctions entre enfants du
donneur et personnes conçues par don soulignent ensuite qu’au-delà de la
dimension génétique, c’est l’événement du don qui spécifie les liens entre
personnes issues du même don. Plus qu’un géniteur, elles partagent les
circonstances de leur conception, dont découlent un récit partagé et des
expériences communes. Enfin, si les relations qui s’établissent de fait se
caractérisent par leur souplesse et leur dimension élective, elles n’en font pas
moins émerger de nouvelles normes et hiérarchies.
Conclusions : L’étude des liens entre
personnes issues du même don laisse entrevoir la constitution d’une nouvelle
catégorie relationnelle aux confins de la parenté.
Contribution : L’article propose
d’aborder la procréation assistée avec tiers donneur par les relations
collatérales qu’elle produit. Il contribue à la réflexion sur le contenu des
liens créés par les « origines ».
La participation de l’enfant en
protection de l’enfance : Enjeux, conditions et obstacles
Authors: Faisca Élodie 
Published: October 2021

Cadre de la recherche : Cet article
propose une revue de la littérature internationale sur les enjeux, les
conditions et les obstacles de la participation des enfants en protection de
l’enfance dans le but de repérer les questions intéressantes à explorer dans de
futurs travaux.
Objectifs : Il vise à repérer les
questions intéressantes à explorer dans de futurs travaux et comprendre les
écarts existants entre les exigences du cadre légal, les discours des
institutions et de leurs acteurs, et les pratiques des professionnels. Il
fournit des pistes de réflexion nouvelles sur les conditions de participation
des enfants.
Méthodologie : L’article s’appuie sur
l’analyse d’une quarantaine de travaux internationaux publiés depuis 20 ans. Les
mots clés mobilisés dans les bases de données en français et en anglais sont :
la participation, des enfants ou des jeunes en protection de l’enfance, de leur
engagement ou implication.
Résultats : L’article met en lumière la
nécessité de repenser l’opposition souvent énoncée entre le principe de
protection et le principe de participation. Il montre l’importance de réfléchir
aux objectifs visés par la participation aux espaces dans lesquels les enfants
sont invités à exprimer leur avis et aux formes que cette expression peut
prendre. Nous montrons que la participation doit être considérée comme un
processus dynamique qui s’active ou se limite dans l’intervention elle-même.

Conclusions : Des recherches
qualitatives, de type ethnographique et longitudinal sont nécessaires pour mieux
saisir les processus à l’œuvre.
Contribution : S’appuyant sur une revue
de littérature, cet article souligne certains des enjeux de la participation des
enfants en protection de l’enfance et identifie des pistes à explorer ou à
approfondir pour la recherche. Il invite alors les lecteurs à considérer et à
étudier la participation de l’enfant en tenant compte de son caractère
dynamique, relationnel et multidimensionnel. Des possibilités analytiques
pourraient émerger grâce à une approche longitudinale et écologique de la
participation.
Identity and Antibiogram of Bacterial Isolates from Owerri Modern Abattoir, Imo State, Nigeria
Authors: Dike-Ndudim Joy Nkeiruka , Nwanneka Ugwuegbu Roseline , Chidozie Amah Henry , Ndubueze Chizaram Winners , Simon Anikwo Emeka 
Published: October 2021

Aim: The identity and antibiogram of bacterial isolates from Owerri modern abattoir in Imo State, Nigeria, was investigated with the aim of determining the bacterial profile of the abattoir and their susceptibility pattern to commonly used antibiotics.
Study Design: Cross sectional study
Place and Duration of Study: This study was carried out in Owerri Modern Abattoir located within Owerri metropolis from June to November, 2020.
Methodology: Questionnaires were used to obtain participants’ consent, demographic data and sanitary practices in the abattoir. Samples were taken and bacteriological analysis of the samples done using pour plate method. Disc diffusion antibiotic susceptibility testing and minimum inhibitory concentration were performed after colony counting, identification and characterization of the isolates using standard microbiological and biochemical techniques.
Results: Mean viable bacterial counts were generally high with highest counts from contaminated soil (6.13x106CFU/ml) and least from workers hands (1.17x106CFU/ml). Escherichia coli had the highest prevalence (18.0%), with the highest counts from soil (3.10%). Vibrio cholerae recorded the least prevalence (0.62%), and was isolated only from washing water. High resistance to antibiotics was observed.
Conclusion: Government authority and the general public are advised to ensure adequate environmental sanitation and proper cooking of meat before consumption in order to mitigate the incidence of infection and antibiotic resistance.
Transferosomes a New Transformation in Research: A Review
Authors: Sasikala Allam 
Published: October 2021

The drugs mostly present are available with less bioavailability and the problem arises with less permeation or solubility so extensive work is done to enhance these mechanisms. Not only that drugs should pass hepatic metabolism, Inorder to improve its bioavailability they are formulated as transferosomes which can improve the patient compliance by delivering the drug through the transdermal-route. Soya lecithin is used as a phospholipid whereas Tween 60, Tween 80, Span 60 and Span 80 are used as edge activators. These formulations usually showed more entrapment efficiency. The reason behind this is due to the presence of more phospholipids and as the surfactant concentration increases drug release will be rapid. As our main aim is to enhance the bioavailability this can be achieved by optimizing the concentrations of phospholipid and surfactant one can attain a controlled release of drug through this drug delivery system.
Corrections of photon beam profiles of small fields measured with ionization chambers using a three‐layer neural network
Authors: Schönfeld Ann‐Britt , Mund Karl , Yan Guanghua , Schönfeld Andreas Alexander , Looe Hui Khee , Poppe Björn 
Published: October 2021

AbstractThe purpose of this work is to study the feasibility of photon beam profile deconvolution using a feedforward neural network (NN) in very small fields (down to 0.56 × 0.56 cm2). The method's independence of the delivery and scanning system is also investigated. Lateral beam profiles of photon fields between 0.56 × 0.56 cm2 and 4.03 × 4.03 cm2 were collected on a Siemens Artiste linear accelerator. Three scanning ionization chambers (SNC 125c, PTW 31021, and PTW 31022) of sensitive volumes ranging from 0.016 cm3 to 0.108 cm3 were used with a PTW MP3 water phantom. A reference dataset was also collected with a PTW 60019 microDiamond detector to train and test individual NNs for each ionization chamber. Further testing of the trained NNs was performed with additional test data collected on an Elekta Synergy linear accelerator using a Sun Nuclear 3D Scanner. The results were evaluated with a 1D gamma analysis (0.5 mm/0.5%). After the deconvolution, the gamma passing rates increased from 54.79% to 99.58% for the SNC 125c, from 57.09% to 99.83% for the PTW 31021, and from 91.03% to 96.36% for the PTW 31022. The delivery system, the scanning system, the scanning mode (continuous vs. step‐by‐step), and the electrometer had no significant influence on the results. This study successfully demonstrated the feasibility of using NN to correct the beam profiles of very small photon fields collected with ionization chambers of various sizes. Its independence of the delivery and scanning system was also shown.
Oxygen Vacancy Injection as a Pathway to Enhancing Electromechanical Response in Ferroelectrics
Authors: Kelley Kyle P. , Morozovska Anna N. , Eliseev Eugene A. , Sharma Vinit , Yilmaz Dundar E. , van Duin Adri C. T. , Ganesh Panchapakesan , Borisevich Albina , Jesse Stephen , Maksymovych Peter , Balke Nina , Kalinin Sergei V. , Vasudevan Rama K. 
Published: October 2021

AbstractSince their discovery in late 1940s, perovskite ferroelectric materials have become one of the central objects of condensed matter physics and materials science due to the broad spectrum of functional behaviors they exhibit, including electro‐optical phenomena and strong electromechanical coupling. In such disordered materials, the static properties of defects such as oxygen vacancies are well explored but the dynamic effects are less understood. In this work, the first observation of enhanced electromechanical response in BaTiO3 thin films is reported driven via dynamic local oxygen vacancy control in piezoresponse force microscopy (PFM). A persistence in peizoelectricity past the bulk Curie temperature and an enhanced electromechanical response due to a created internal electric field that further enhances the intrinsic electrostriction are explicitly demonstrated. The findings are supported by a series of temperature dependent band excitation PFM in ultrahigh vacuum and a combination of modeling techniques including finite element modeling, reactive force field, and density functional theory. This study shows the pivotal role that dynamics of vacancies in complex oxides can play in determining functional properties and thus provides a new route toward– achieving enhanced ferroic response with higher functional temperature windows in ferroelectrics and other ferroic materials.
Role of metal identity and speciation in the low‐temperature oxidation of methane over tri‐metal oxo clusters
Authors: Hall Jacklyn N. , Bollini Praveen 
Published: October 2021

AbstractClarity as to the role of metal identity and oxidation state in effecting redox and acid‐catalyzed turnovers is oftentimes precluded by a high degree of heterogeneity in site speciation, a limitation that can be overcome through the use of well‐defined polymetal clusters hosted by metal organic framework materials—accomplished in the present case using MIL‐100(M) for the low temperature oxidation of methane with N2O. Transient kinetic data point to (a) methoxy species mediating methane conversion, (b) partial and deep oxidation occurring over metal sites distinct in oxidation state, (c) chromium clusters amplifying the propensity towards C‐C bond formation, and (d) the relative velocity of propagation of water and methanol concentration fronts playing a determinative role in maximizing C2 oxygenate selectivity. The study captures the utility of using classes of materials inherently endowed with a high level of definition and uniformity in advancing the elucidation of structure‐catalytic property relationships.
Crystallization solvent design based on a new quantitative prediction model of crystal morphology
Authors: Chai Shiyang , Li Enhui , Zhang Lei , Du Jian , Meng Qingwei 
Published: October 2021

AbstractSolution crystallization is an important separation unit operation in active pharmaceutical ingredient production. Solvent is one of the important factors affecting crystal morphology. How to select/design suitable solvents is still one of the most urgent problems in the crystallization field. In this article, a framework for crystallization solvent design based on the developed quantitative prediction model of crystal morphology is proposed. First, molecular dynamics is used to predict the crystal morphology in solvents. Next, solvent descriptors are selected by stepwise regression method. Then, the quantitative relationship between crystal aspect ratio and solvent descriptors is developed. Subsequently, computer‐aided molecular design method is integrated with the developed quantitative prediction model. The crystallization solvent design problem is expressed as a mixed‐integer nonlinear programming model with maximum yield as the objective function, which is solved by decomposition algorithm. Finally, the crystallization solvent design framework is applied to two cases and experimental verification is implemented.
Disability organizations as empowering settings: Challenging stigmatization, promoting emancipation
Authors: Madyaningrum Monica E. , Sonn Christopher C. , Fisher Adrian T. 
Published: October 2021

AbstractThis study investigated how a local disability organization in Yogyakarta Province, Indonesia, has functioned as an empowering setting for its members. This article discusses, in particular, the context specific features that have enabled members of this organization to resist the pervasive stigmatization commonly imposed upon people with disabilities. The research data was collected through interviews with 18 members of the organization and analyzed using the method of constructivist grounded theory. The findings suggest that this organization exists as an empowering setting because it functions as a mindset changer, an alternative resource center, and fosters supportive and courageous allies. Through this empowerment, members can challenge the normalized stigmatization and promote more emancipatory identities, particularly in a rural context where some socio‐cultural aspects may further complicate the disadvantages of people with disabilities. Implications for future research and disability interventions are discussed.
Sink/Float Magnetic Immunoassays for In‐Field Bioassays
Authors: Chorti Parthena , Christodouleas Dionysios C. 
Published: October 2021

AbstractAnalytical tests/devices that are used outside laboratory settings are required to have a very simple analytical protocol to get clearance by regulatory authorities. This study describes sink/float magnetic immunoassays, a new type of rapid, mix‐and‐observe, instrument‐free tests for the detection of biomarkers in untreated biological samples that are very simple and might meet the simple‐to‐use criterion of authorities to be used in the field. These tests can tell whether an analyte is above or below a predetermined level within 25–45 minutes based on the sinking or floating of a mm‐sized sphere on the surface of which an immunoassay that uses reporter antibodies conjugated to superparamagnetic nanoparticles is performed. This manuscript describes the theory and proof‐of‐concept applications of sink/float magnetic immunoassays for the detection of C‐Reactive Protein, anti‐Treponema pallidum antibodies and E. coli bacteria.
Targeted Enrichment of Enzyme‐Instructed Assemblies in Cancer Cell Lysosomes Turns Immunologically Cold Tumors Hot
Authors: Ji Shenglu , Li Jun , Duan Xingchen , Zhang Jingtian , Zhang Yufan , Song Mengqing , Li Songge , Chen Hongli , Ding Dan 
Published: October 2021

AbstractLysosome‐relevant cell death induced by lysosomal membrane permeabilization (LMP) has recently attracted increasing attention. However, nearly no studies show that currently available LMP inducers can evoke immunogenic cell death (ICD) or convert immunologically cold tumors to hot. Herein, we report a LMP inducer named TPE‐Py‐pYK(TPP)pY, which can respond to alkaline phosphatase (ALP), leading to formation of nanoassembies along with fluorescence and singlet oxygen turn‐on. TPE‐Py‐pYK(TPP)pY tends to accumulate in ALP‐overexpressed cancer cell lysosomes as well as induce LMP and rupture of lysosomal membranes to massively evoke ICD. Such LMP‐induced ICD effectively converts immunologically cold tumors to hot as evidenced by abundant CD8+ and CD4+ T cells infiltration into the cold tumors. Exposure of ALP‐catalyzed nanoassemblies in cancer cell lysosomes to light further intensifies the processes of LMP, ICD and cold‐to‐hot tumor conversion. This work thus builds a new bridge between lysosome‐relevant cell death and cancer immunotherapy.
Prompting visual attention to print versus pictures during shared book reading with digital storybooks for preschoolers withASDcompared toTDpeers
Authors: Wicks Rachelle , Westerveld Marleen , Stainer Matthew , Paynter Jessica 
Published: October 2021

AbstractPrompting children to look at print and picture content during shared book reading (SBR) facilitates joint attention and early language and literacy learning opportunities for typically developing (TD) children. Whether preschoolers with autism spectrum disorder (ASD) respond similarly to bids for joint attention during SBR and how autism characteristics impact upon their responsiveness is currently unclear. This is important given these children are at risk of persistent language and literacy challenges. To address this, we examined the effects of prompts that were solely verbal versus verbal with pointing on visual attention to print and picture targets during SBR with digital storybooks for 34 children with ASD and 27 TD peers. Children with ASD looked as frequently at print targets, but less frequently at picture targets, when prompted compared to TD peers. Both prompt types showed similar effects in shifting children's visual attention to print and picture targets at group level. When groups were combined, autism characteristics influenced children's responsiveness to verbal versus verbal with pointing prompts to print targets, but not to picture targets; children looked more frequently at print targets as autism characteristics increased when verbal prompts were used, with a large effect shown (d = 0.91). Overall, findings suggest that prompting children with ASD to look at print and pictures during SBR with digital storybooks may be helpful in facilitating joint attention to storybook content. Implications for the development of effective early interventions aimed at providing emergent literacy support for children with ASD are discussed.Lay SummaryWe looked at how prompting impacted upon where children with autism look during shared book reading with digital storybooks compared to children without autism using eye‐tracking. We found the target (pictures or print) was what mattered and number of autism characteristics impacted how responsive children were to different types of prompts. This helps us to understand how prompting may help children with autism to look at print or pictures during shared book reading which could support language or reading interventions.
Density functional theory study of the dimer structure of amyloidogenic active sequence VQIVYK
Authors: Choi Ryu Ho , Kim Ho‐Tae 
Published: October 2021

AbstractThe density functional theory calculations at the B3LYP/6‐31G(d) level were used to optimize the VQIVYK dimer complexes. In the stabilization energy calculations, the Complex 4 structure was calculated to be the most favorable structure among the Complex 1–5 geometries. The Complex 4 geometry was shown to be a more favorable geometry because of the less rigid geometry of the QIVY central part than the well‐ordered QIVY part of the Complex 1 parallel geometry. The central part of Complex 4 QIVY is optimized to the Y‐association structure of the Y5–Q2–Y5 interaction geometry. The Y5–Q2–Y5 interaction comprised two interactions, the Y5–Y5 pi–pi interaction and two cooperative H‐bonds. Both pi–pi interaction and the two cooperative H‐bonds contributed to the energy stabilization of Complex 4 geometry.
Development, validation, and implementation of an UHPLC–MS/MS method for the quantitation of furosemide in infant urine samples
Authors: Vedar Christina , Bamat Nicolas A. , Zuppa Athena F. , Reilly Megan E. , Moorthy Ganesh S. 
Published: October 2021

AbstractFurosemide is a diuretic drug used to increase urine flow in order to reduce the amount of salt and water in the body. It is commonly utilized to treat preterm infants with chronic lung disease of prematurity. There is a need for a simple and reliable quantitation of furosemide in human urine. We have developed and validated an ultra‐high performance liquid chromatography–tandem mass spectrometry method for furosemide quantitation in human urine with an assay range of 0.100–50.0 μg/ml. Sample preparation involved solid‐phase extraction with 10 μl of urine. Intra‐day accuracies and precisions for the quality control samples were 94.5–106 and 1.86–10.2%, respectively, while inter‐day accuracies and precision were 99.2–102 and 3.38–7.41%, respectively. Recovery for furosemide had an average of 23.8%, with an average matrix effect of 101%. Furosemide was stable in human urine under the assay conditions. Stability for furosemide was shown at 1 week (room temperature, 4, −20 and −78°C), 6 months (−78°C), and through three freeze–thaw cycles. This robust assay demonstrates accurate and precise quantitation of furosemide in a small volume (10 μl) of human urine. It is currently being implemented in an ongoing pediatric clinical study.
Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC–MS: Source species for valuable compounds with drug or drug potential
Authors: Akdeniz Mehmet , Yener Ismail , Dincel Demet , Firat Mehmet , Karatas Degirmenci Dilek , Ertas Abdulselam 
Published: October 2021

AbstractPublic use of Salvia species and their importance in the scientific world is continually increasing. It is known that this use and the importance of Salvia species are mostly due to the terpenoid compounds that they contain. In this context, the terpenoid–steroid–flavonoid contents of extracts of six endemic Salvia (S. kurdica, S. pseudeuphratica, S. rosifolia, S. siirtica, S. cerino‐pruinosa var. cerino‐pruinosa and S. cerino‐pruinosa var. elazigensis) species prepared with different solvents were determined by gas chromatography–mass spectrometry. Within the framework of the ingredient analysis, content analysis of the ethanol extracts of the root, branch, leaf and flower parts of the species collected in the same period between 2015 and 2017 years was performed. In general, extracts prepared with chloroform and ethanol were found to contain a wide variety of compounds while petroleum ether extracts were found to contain much less varied compounds. In addition, in general, root extracts are richer in terpenoid compounds than aerial part extracts. Some species can be used as source species in terms of ferruginol, cryptanol, 6,7‐dehydroroyleanone, lup‐(20)29‐ene‐2α‐hydroxy‐3β‐acetate, salvigenin and β‐sitosterol contents (52,114.28, 75,979.08, 101,247.41, 40,071.29, 33,952.13 and 34,010.90 μg analyte/g extract, respectively).