bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEATH ITSELF - STUDENTS’ PERSPECTIVE OF AZAD JAMMU & KASHMIR MEDICAL COLLEGE
Authors: Manzoor Shamaila , Rehman Atiq -Ur- , Kiyani Ziyad , Younas Ayesha , Minhas Rafia 
Published: May 2021

Objective: To outline a frame-work which would help to regulate the emotions of under graduate students, on the death of their patient.
Study Design: An exploratory qualitative study.
Place and Duration of Study: Azad Jammu & Kashmir Medical College (AJKMC), from Nov 2019 to Dec 2019.
Methodology: Purposive sampling was done from the final year medical students and focus group discussions were carried out for data collection. Twenty five students shared their feelings at the death of first patient under their care. As a whole, 92% of volunteers experienced the death of their first patients in medical settings. Subsequently, four main themes have been emerged after data analysis. Including; unexpected death, crisis, anticipated death & resolution.
Results: Inadequate preparation of medical scholars to handle this tragic incidence leads to anxiety, anger, guilt and sense of helplessness. These undesirable sentiments would seriously affect their performance in future. So, they must be handled wisely and professionally.
Conclusion: Consequently, a curricular model emerged as a result of this study recommending following steps. There should be regular debriefing sessions of students from their supervisors and reflective journaling practice of students, as a part of curriculum. Likewise, faculty training for „end of life theme‟ would help their students to become more valuable for ailing community.
CLINICAL PROFILES AND OUTCOMES OF PATIENTS ADMITTED WITH MODERATE TO CRITICAL CORONAVIRUS DISEASE 2019 (COVID-19)
Authors: Hussain Mehmood 
Published: May 2021

Objective: To evaluate various demographic, clinical, radiological and hematological manifestations of moderate to critical coronavirus disease 2019 (COVID-19) and to assess its complications and outcomes in the Pakistani population.
Study Design: Retrospective observational study.
Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi, from Apr to Jul 2020.
Methodology: Demographic, clinical, radiological and hematological data of 600 consecutive patients were retrieved and analyzed from hospital registry.
Results: Overall, 449 (74.8%) patients had at least 1 comorbidity, diabetes mellitus being commonest; 228 (38%) [95% CI, 34.1- 42%]. The most common symptoms were cough; 451 (75.2%), fever; 450 (75%) and shortness of breath; 419 (69.8%). At presentation, 222 (37%) patients had moderate disease, 296 (49.3%) severe and 82 (12.7%) had critical disease. At admission, 277 (46.2%) patients required respiratory support and further 185 (30.8%) patients required treatment escalation later on correlated with disease severity and age (p<0.001). A total of 92 (15.3%) patients died out of which 38 (21.2%) were on noninvasive ventilation and 36 (66.6%) on invasive ventilation, (p<0.001). Overall survival (OS) was 84.7%; log rank <0.001. Mortality was highest in critical disease, 72 (31.3%) (p<0.001). A majority of patients, 440 (73.3%) developed complications, the most commonbeing Cytokine release storm (CRS); 57.5% respiratory failure; 43.8% and Acute respiratory distress syndrome (ARDS); 38.8%. Thrombotic events occurred in 106 (17.6%).Conclusion: Majority of patients with moderate to severe COVID-19 had comorbidities and ended up in variouscomplications.
PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
Authors: Atta Muhammad Fahad , Qamar Khadija , Iram Maria , Safdar Saba Saleem , Faisal Tayyaba , Shan Maryam 
Published: May 2021

Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile.
Study Design: Laboratory-based experimental study.
Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020.
Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups.
Results: Rats exposed to mosquito coil smoke alone showed significantly less weight gain (p<0.001)), testicular weight (p<0.001), volume (p<0.001), and relative tissue body weight index (p<0.001) as compared to control group. Rats administered Coenzyme Q10 along with mosquito coil smoke exposure exhibited significantly higher weight gain (p<0.001), testicular weight (p<0.001), volume (p<0.001) and relative tissue body weight index (p<0.001) as compared to rats exposed to mosquito coil smoke alone.
Conclusion: Long-term inhalation of allethrin-based mosquito coil smoke caused testicular atrophy among rats, as evident by reduced testicular weight, volume and relative tissue body weight index. Whereas, prophylactic oral administration of Coenzyme......................
DIAGNOSTIC DILEMMA AND TREATMENT CHALLENGES IN IDIOPATHIC GRANULOMATOUS MASTITIS
Authors: Latif Humera , Qamar Naqvi Syeda Rifaat , Bano Razia , Farrukh Nida , Ali Kishwar , Sana Faiza 
Published: May 2021

Objective: To outline diagnostic difficulties and problems in the treatment of Idiopathic Granulomatous Mastitis
Study Design: Prospective observational study.
Place and Duration of Study: Breast clinic, Combined Military Hospital Rawalpindi, from Aug 2019 to Jul 2020.
Methodology: Patients with tender mass with or without signs of inflammation, mass with abscess, sinus formation, and with recurrent abscesses were included. Those cases were labelled as IGM whose histopathology showed granulomatous mastitis with no evidence of malignancy and tissue cultures were negative. Patients with mild to moderate symptoms were treated with reassurance, analgesia and multivitamins. Abscesses were treated with incision & drainage and empirical antibiotics for 1-2 weeks. All these patients were followed at 1, 3, 6 and 12 months.
Results: A total of 35 patients fulfilled the criteria for Idiopathic Granulomatous Mastitis and were included in the study. Two patients had lactational abscess, 3 had bilateral disease and 1 patient was with diabetes 0% patients were having mass with abscess; spontaneous resolution was observed in majority of them with a few requiring incision and drainage. Of 31.4% presented with tender mass only; majority of them resolved with observation, except mass excision in two patients, 19.7% presented with discharging sinuses with underlying mass; among them 71% responded to conservative treatment while 29% were treated with anti-tuberculous therapy for recurrent sinuses. 8.5% presented with spontaneously ruptured abscesses with sinuses; they were managed conservatively.
Conclusion: We concluded that Idiopathic Granulomatous Mastitisis a benign self-limiting disease which can be effectively managed with conservative treatment.
EMOTIONAL INTELLIGENCE AND JOB SATISFACTION AMONG MEDICAL TEACHING FACULTY
Authors: Bano Uzma , Ahmed Anis , Aziz Shahid , Tassadaq Noreen , Ahsan Omar , Wasim Minahil 
Published: May 2021

Objective: To measure the correlation between emotional intelligence (EI) and job satisfaction (JS) among teaching faculty of Foundation University Medical College.
Study Design: Cross-sectional study.
Place and Duration of Study: Study was carried out at Foundation University Medical College (FUMC), Islamabad, from Mar to Apr 2021.
Methodology: Participants were recruited through survey sampling using “Google Forms.”Faculty members with a total teaching experience of more than 05 years in FUMC were included in the study. EI was measured using Wong and Law Emotional Intelligence scale- Short version (WLEIS), while JS was measured using Brayfield and Rothes scale on a 5-point Likert scale. Data was entered and analyzed using SPSS version 17. The WLEIS score was correlated to the JS score using Pearson r correlation.
Results: Total 89 faculty members had a teaching experience of more than 5 years. Survey had a response rate of 76.4%. Study included 68 faculty members; 26 (38.2%) were from basic sciences and 42 (61.8%) were from clinical sciences. The mean EI score was 3.22 ± 0.70; and the mean JS satisfaction score was 3.05 ± 0.86. All facets of emotional intelligence as well as overall emotional intelligence scores showed significant positive correlation with job satisfaction scores; which were statistically significant; p<0.05.
Conclusion: There was a statistically significant positive correlation between all components of emotional intelligence and job satisfaction. Hence, it is important for the medical colleges to concentrate on those practices that promote emotional intelligence among their teaching faculty.
Pengaruh Gaya Kepemimpinan Transaksional Dan Gaya Kepemimpinan Transformasional Terhadap Kinerja Karyawan Dengan Komitmen Organisasi Sebagai Variabel Moderating Pada PT. Bangun Mitra Abadi Medan
Authors: Putra Rizky 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan transaksional dan transformasional terhadap kinerja karyawan baik secara parsial maupun simultan. Untuk mengetahui apakah komitmen organisasi memoderasi pengaruh gaya kepemimpinan transaksional dan gaya kepemimpinan transformasional terhadap kinerja karyawan pada. Jumlah sampel sebesar 116 orang dengan menggunakan teknik regresi linier berganda dan MRA. Hasil
penelitian menunjukkan bahwa gaya kepemimpinan transaksional dan gaya kepemimpinan transformasional berpengaruh terhadap kinerja karyawan secara parsial dam simultan. Komitmen organisasi terbukti signifikan dalam memoderasi gaya kepemimpinan transaksional terhadap kinerja karyawan serta komitmen organisasi terbukti signifikan dalam memoderasi gaya kepemimpinan transformasional terhadap kinerja karyawan.
Clinical efficiency of antioxidant therapy in patients with liver cirrhosis and acute blood loss
Authors: Evseenko D. A. , Dundarov Z. A. 
Published: May 2021

Objective:to determine the clinical efficiency of antioxidant therapy in patients with liver cirrhosis and acute blood loss.Material and methods.The study included 286 patients with liver cirrhosis and acute blood loss of varying degrees of severity. The patients were divided into two series of studies. In the first series, the patients received the therapy according to the clinical diagnostic and treatment protocols, in the second series 1 according to the same protocols in combination with an intravenous administration of the antioxidant complexes “Reamberin” and “Fluimucil”. After 48 hours from admission, the antioxidant status of blood serum, the blebbing index of lymphocytes, the concentration of uric acid, and the level of hemoglobin were analyzed. The indicators of the clinical efficiency of the treatment were determined: risk of absolute mortality, risk of relative mortality, the number needed to treat.Results.The blood serum of the patients from the first series of studies was characterized by pronounced prooxidant activity, high values of the lymphocyte blebbing index, and a small amount of uric acid, which was indicative of the development of oxidative stress. The mortality rate in this series of studies was 26.0 %. The patients of the second series of studies were characterized by pronounced antioxidant activity of blood serum, low values of the lymphocyte blebbing index, and high concentrations of uric acid, which indicated a decrease in the activity of systemic oxidation processes. The mortality rate in this series of studies was 18.2 %. The duration of the treatment decreased from 16.5 days (first series) to 13.0 days (second series).Conclusion.The combined use of the “Reamberin” and “Fluimucil” complexes as part of the therapy according to the clinical diagnostic and treatment protocols leads to a relief of oxidative stress in patients with liver cirrhosis complicated by acute blood loss. The blood serum of these patients is characterized by pronounced antioxidant activity, low values of the lymphocyte blebbing index, and a high concentration of uric acid, which reduces the risk for the development of multiple organ failure syndrome. This therapy decreases the mortality rate to 18.2 % and the duration of the treatment to 13.0 days.
Features of the topography of the unpaired visceral branches of the abdominal aorta in terms of age and sex
Authors: Grishechkin V. Yu. , Vvedenski D. V. , Zhdanovich V. N. 
Published: May 2021

Objective:to study the features of the topography of the unpaired visceral branches of the abdominal aorta in men and women at different periods of adulthood.Material and methods.We analyzed 190 (93 male and 97 female) computer scans of the abdominal aorta with no cases of vascular and other pathology detected in the patients.Results.It has been found that the topographic parameters of the unpaired visceral branches of the abdominal aorta change with age in both the men and women. In the women in all age groups, the orifice of the celiac trunk is located higher than in the men. In 31.3 % of the women, the origin of the celiac trunk corresponds to the Th12–L1 level of the intervertebral disc, and in 37.0 % of the men — to the intervertebral disc L1–L2. The orifice of the superior mesenteric artery is skeletotopically located at the level of the middle of the body L1 in 25.9 % of the men and in 25.2 % of the women. The orifice of the inferior mesenteric artery in 40.4 % of the men corresponds to the lower edge of the body L3, and in 36.4 % of the women — to the level of the middle edge of the body L3.Conclusion.The obtained data on the sex and age characteristics of the position of the orifice of the celiac trunk, superior and inferior mesenteric arteries are not only of anatomical interest, but also of clinical significance in angiography, abdominal surgical interventions and in X-ray endovascular surgery.
New approaches to sonomorphometry of the inferior vena cava in children
Authors: Yurkovskiy A. M. , Yurkovskiy D. S. 
Published: May 2021

Objective: to develop a criterion for normality/abnormality of the inferior vena cava diameter in children that is convenient to use in wide clinical practice.Material. In order to achieve the above objective, we performed measurements of the antero-posterior cross-section of the inferior vena cava in children (n = 100) in different age periods.Results. We have determined a criterion allowing of assessing the normality/abnormality of the inferior vena cava diameter in different age periods with sufficiently high accuracy.Conclusion. The work has concluded on the potential of the use of the coefficient reflecting the ratio of height and diameter (range — 0.04–0.1) as a reliable reference point for the assessment of the normality / abnormality of the inferior vena cava diameter in different age periods.
Cost-benefit analysis of the use of invasive intraoperative hemodynamic control of the state of peripheral blood flow in endovascular or hybrid reconstruction of multisegment lesions in chronic arterial occlusive disease of the lower extremities
Authors: Gorokhovsky S. Yu. , Lyzikov A. A. , Lyzikova T. V. , Kaplan M. L. , Tihmanovich V. E. 
Published: May 2021

Objective: to evaluate the cost-benefit ratio of the use of invasive intraoperative hemodynamic control of peripheral blood flow during correction of multilevel lesions in chronic arterial occlusive disease of the lower extremities.Material and methods. We compared the cost of the in-hospital period of treatment among patients of 3 comparable groups: the patients of the first group underwent interventions under angiographic control, of the second — under invasive intraoperative hemodynamic control of the state of peripheral blood flow in addition to angiography, and in the patients of the third group invasive hemodynamic control of the state of peripheral blood flow was followed by pharmacological tests.Results. The use of the given method made it possible to correct the extent of the performed procedures of revascularization and to estimate the efficiency of the phases of the operation in real time. The result of interventions in the groups with hemodynamic control was a reliable increase of the ankle-brachial index (ABI index) values (p — 00001) in shorter length of segments after revascularization (p — 0.05). At the same time, the reduced extent of the correction resulted in saving 807 BYN per case.Conclusion. The use of invasive intraoperative hemodynamic control allows of reducing the extent of the reconstruction in multisegment lesions with the achievement of satisfactory clinical outcomes with lesser economic costs.
Analysis of quality of life in patients with locally advanced oral and oropharyngeal cancers
Authors: Trizna N. M. , Kaliadzich Zh. V. , Sharshakova T. M. , Evmenenko A. A. 
Published: May 2021

Objective: to study the quality of life in patients who underwent surgical intervention on cancerous tumors of the mucous membrane of the oral cavity and oropharynx.Material and methods. An analysis of the quality of life was performed in 31 patients with tumors of the mucous membrane of the oral cavity and oropharynx using the EORTC QLQ-30 and EORTC QLQ-H & N35 questionnaires.Results. The study of the quality of life using the EORTC QLQ-30 questionnaire in dynamics revealed improved general health status, emotional functioning, cognitive function, lower pain level, decreased frequency of insomnia (p> 0.05). The assessment of clinical meaning and magnitude according to K. Cocks et al. showed that these factors were characterized by a low level of clinical meaning and magnitude of changes in the studied parameters for all scales, except for the insomnia scale corresponding to an average level of clinical meaning and magnitude. At the same time, a statistically significant change score in the fatigue scales (p <0.01) corresponded to a low level of clinical meaning and magnitude, and low appetite (p < 0.05) should be r egarded as irrelevant. The survey of the patients using the EORTC QLQ — H & N35 questionnaire showed deterioration in some functions associated with the consequences of anticancer treatment, including impaired taste and odor perception (p < 0.01), speech disorders (p < 0.05), difficulties related to eating in public places (p < 0.01), difficulties in social contacts (p < 0.05), viscous saliva (p <0.05).Conclusion. The study has revealed positive changes in the quality of life of patients with oral and oropharyngeal cancers in the period from 4 to 6 months after the end of treatment, which indicates a gradual return to the initial level of vital activity and the need for regular monitoring of the quality of life of the patients in the long follow-up.
Ascariasis as a factor changing the expression levels of BIRC-5, GLI, VEGF and TP53 suppressor gene in tissue biopsies in rats during the reproduction of experimental C6 glioma
Authors: Pabyarzhin V. V. 
Published: May 2021

Objective: to study ascariasis as a factor leading to changes in the expression levels of BIRC-5, GLI, VEGF and the TP53 suppressor gene in tissue biopsies in rats during the reproduction of experimental C6 glioma.Material and methods. C6 glioma tumor was modelled in situ in female rats of the first (“control group with tumor”) and second groups (“glioma in combination with ascariasis”). The material was taken on the 14th, 21st, 28th, 35th days of tumor development in the animals of the first group, on the 7th (14th day of tumor development), 14th (21st day of tumor development), 21st (28th day of tumor development), 28th day after infection (35th day of tumor development) in the females of the second group. The animals of the third group were healthy (10 animals). Tissue biopsies were taken from them once.Results. TThe A. suum invasion of the animals at a dose of 40 eggs per gram of animal body weight increases the expression of BIRC-5, GLI, VEGF genes and the TP53 suppressor gene in the rats with experimental glioma.Conclusion. Therefore, the authors` experimental model of C6 glioma in situ in rats has showed that the A. suum invasion at a dose of 40 eggs per gram of body weight increases the expression of BIRC-5, GLI, VEGF genes and TP53 suppressor gene in rats with experimental glioma.
Pandemic COVID-19: problems and prospects of remote teaching of the discipline «Phthisiopulmonology» in selected CIS countries
Authors: Kolomietz V. M. , Pavlenko E. P. , Buinevich I. V. , Tashpulatova F. K. 
Published: May 2021

Objective: to analyze the effectiveness and characteristics of teaching the discipline “Phthisiopulmonology” with the use of various methods in the training of physicians during the pandemic.Material and methods. We analyzed modern publications on the problem, performed comparative interpretation of the first results of the use of the distance format of academic process for the teaching of the clinical discipline “Phthisiopulmonology” at specialized departments of universities in selected CIS countries.Results. In the spring of 2020, the system of higher medical education was forced to transition to teaching students with the use of online techniques. This teaching method is almost always evaluated positively for a number of reasons. Teaching at the clinical departments of medical universities, where practical skills are priority in contact with patients, may incorporate only elements of remote techniques. The phthisiopulmonology departments of medical universities (Kursk, Gomel, Tashkent) applied various techniques of remote teaching during the pandemic.Conclusion. The first results of the use of the distance format has demonstrated that the use of the hybrid method (full-time training with elements of distance learning) is the most reasonable for teaching clinical rotations.
Mechanical properties of the surface of gastric epithelial cells in patients with oncologic pathology
Authors: Shaforost A. S. , Voropaev E. V. , Achinovich S. L. , Silin R. A. 
Published: May 2021

Objective:to study the efficiency of the application of atomic force microscopy for the identification of differences in the structural and mechanical properties of gastric epithelial cells in normal conditions and in gastric cancer.Material and methods.The structural and mechanical properties of the membrane of the epithelial cells of the gastric mucosa in 7 patients with gastric cancer were assessed using atomic force microscopy in contact mode.Results.The comparison of the size and shape of gastric mucous cells (GLC), their healthy and tumor areas has showed that in both the cases they have a slightly elongated rounded shape and similar dimensions: length × width × height of the cell is norm (in μm): 7.5 × 6.8 × 0.6, and in case of oncologic pathology (in μm): 7.2 × 6.9 × 1.0. Tumor cells are characterized by a 13% increase in their surface roughness compared to normal epithelial cells. The lateral force microscopy method allows of obtaining data on the structure of the submembrane cortical layer of the cell cytoskeleton. According to experimental data, a 2.48-fold decrease in the value of the friction force (Fl) in epithelial cells from healthy areas of the coolant indicates increased density and integrity of the cortical layer of the cytoskeleton in normal conditions compared to those of tumor cells.Conclusion.The analysis of the experimental data has found that tumor cells from the gastric mucosa differ from healthy cells in terms of their nanomechanical properties: they are characterized by a rougher surface, which consists of fewer structural elements of a larger size. The work has showed the interrelation of the indicators of the frictional properties of the cell surface: the values of the friction forces and the roughness of the friction map.