bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma
Authors: Kyriakou Sotiris , Cheung William , Mantso Theodora , Mitsiogianni Melina , Anestopoulos Ioannis , Veuger Stephany , Trafalis Dimitris T , Franco Rodrigo , Pappa Aglaia , Tetard David , Panayiotidis Mihalis 
Published: February 2021

Abstract
Melanoma is an aggressive and highly metastatic type of skin cancer where the design of new therapies is of utmost importance for the clinical management of the disease. Thus, we have aimed to investigate the mode of action by which a novel methylated analogue of L-Mimosine (e.g., L-SK-4) exerts its therapeutic potency in an in vitro model of malignant melanoma. Cytotoxicity was assessed by the Alamar Blue assay, oxidative stress by commercially available kits, ROS generation, caspase 3/7 activation and mitochondrial membrane depolarisation by flow cytometry, expression of apoptosis-related proteins by western immunoblotting and profiling of lipid biosynthesis by a metabolomic approach. Overall, higher levels of ROS, sphingolipids and apoptosis were induced by L-SK-4 suggesting that the compound’s therapeutic potency is mediated through elevated ROS levels which promote the upregulation of sphingolipid (ceramide) biosynthesis thus leading to the activation of both extrinsic and intrinsic apoptosis, in an experimental model of malignant melanoma.
Unexpected Redshift of nearby stars
Authors: Kalhor Bahram , Mehrparvar Farzaneh , Kalhor Behnam 
Published: February 2021

Abstract
We report a list of nearby stars whose Redshift is too much higher than other nearby stars based on an analysis of 58,916 stars. We have used SIMBAD Astronomical Database and obtained this information from 1.4 million records. The data indicate that the Redshift of the almost 200 stars does not completely correlate with distance, and there are some exceptions. The high Redshift of nearby stars questions expansion of space and the Hubble constant.
Fine particulate matter constituents associated with emergency room visits for pediatric asthma: A time-stratified case–crossover study in an urban area
Authors: Ho Yu-Ni , Cheng Fu-Jen , Tsai Ming-Ta , Tsai Chih-Min , Chuang Po-Chun , Cheng Chi-Yung 
Published: February 2021

Abstract
Background

Global asthma-related mortality tallies at around 2.5 million annually. Although asthma may be triggered or exacerbated by particulate matter (PM) exposure, studies investigating the relationship of PM and its components with emergency department (ED) visits for pediatric asthma are limited. This study aimed to estimate the impact of short-term exposure to PM constituents on ED visits for pediatric asthma.
Methods

We retrospectively evaluated non-trauma patients aged younger than 17 years who visited the ED with a primary diagnosis of asthma. Further, measurements of PM10, PM2.5, and four PM2.5 components (i.e., nitrate (NO3−), sulfate (SO42−), organic carbon (OC), and elemental carbon (EC)) were collected between 2007 and 2010 from southern particulate matter supersites. These included one core station and two satellite stations in Kaohsiung City, Taiwan. A time-stratified case‐crossover study was conducted to analyze the hazard effect of PM.
Results

Overall, 1597 patients were enrolled in our study. In the single-pollutant model, the estimated risk increase for pediatric asthma incidence on lag 3 were 14.7% [95% confidence interval (CI), 3.2–27.4%], 13.5% (95% CI, 3.3–24.6%), 14.8% (95% CI, 2.5–28.6%), and 19.8% (95% CI, 7.6–33.3%) per interquartile range increments in PM2.5, PM10, nitrate, and OC, respectively. In the two-pollutant models, OC remained significant after adjusting for PM2.5, PM10, and nitrate. During subgroup analysis, children were more vulnerable to PM2.5 and OC during cold days (< 26 °C, interaction p = 0.008 and 0.012, respectively).
Conclusions

Both PM2.5 concentrations and its chemical constituents OC and nitrate are associated with ED visits for pediatric asthma. Among PM2.5 constituents, OC was most closely related to ED visits for pediatric asthma, and children are more vulnerable to PM2.5 and OC during cold days.
Capture - Recapture based Study on The Completeness of Smear Positive Pulmonary Tuberculosis Reporting in southwest Iran during 2016
Authors: Amiri Homayoun , Mohammadi Mohammad javad , alavi Seyed Mohammad , Salmanzadeh Shokrolah , Hematnia Fatemeh , Azar Mahnaz , Rahmatiasl Heydar 
Published: February 2021

Abstract
Background
Tuberculosis (TB) is one of the ten leading causes of death in infectious diseases and one of the ten leading causes of death in the world. For any TB control program, a reliable surveillance is essential. In order to assess the status of the Surveillance, the quality of the record and the completeness of reporting should be assessed. The purpose of this study was to investigate the completeness of smear positive pulmonary tuberculosis reporting in Ahvaz of Iran.
Methods
The study was conducted through a Three-source Capture recapture method by collecting laboratory, hospital, and physician reporting data - including introducing patients to health centers and reviewing drug and laboratory prescriptions. Data analysis was performed using linear logarithm model in Rcapture package R software.
Results
In total, 134 new cases of smear-positive pulmonary tuberculosis were reported through three sources During 2016. The completeness of reporting the disease was estimated 87.5% and the incidence rate was estimated to be 11.8 / 100,000. Completeness of reporting of laboratory, hospital and physician resources were 79%, 30% and 16.3%, respectively.
Conclusion
The present study showed the necessity of evaluating the quality, completeness and linkage between data. Linking between data sources can improve the accuracy and completeness of TB Surveillance.
Japan’s Development Cooperation for Health in Vietnam: a First Holistic Assessment on Japan’s ODA&nbsp;and Non-ODA&nbsp;Public Resources Cooperation
Authors: Lee Sangnim , Tachimori Hisateru , Sugai Maaya Kita , Ishizuka Aya , Uechi Manami , Akashi Hidechika , Hinoshita Eiji , Miyata Hiroaki , Shibuya Kenji 
Published: February 2021

Abstract
BackgroundTo achieve Universal Health Coverage (UHC), which is the core driver of health Sustainable Development Goals (SDGs), by 2030, Japan strives to strengthen its development cooperation by mobilizing various resources. However, the involvement and roles of various actors from Japan in development cooperation for health have not been revealed across various entities of the Japanese government or to the public. This study is the first to systematically assess the overall picture of Japan’s publicly funded cooperation mobilizing Official Development Assistance (ODA) and non-ODA public resources to improve people’s health in Vietnam. MethodsA cross-sectional analysis of Japanese publicly funded projects implemented for health cooperation in Vietnam during December 2016 was conducted. A framework based on the six building blocks of health system defined by the World Health Organization was adopted in order to assess the target projects. ResultsOverall, 68 projects implemented through Japanese public funding were included in the final analysis. These 68 projects under 15 types of schemes were managed by seven different scheme-operating organizations and funded by five ministries. Forty-four of these (64.7 %) were ODA and 24 (35.3 %) were non-ODA projects. Among the recategorized six building blocks of the health system, the focus area of the largest proportion of projects was health service delivery (44 %), followed by health workforces (25 %) and health information systems (15 %). Almost half the projects were implemented together with the central hospitals as Vietnamese counterparts. Only 10 % projects were conducted at the local level. This study was unable to capture the synergetic effects of potential collaboration or harmonization among Japanese funded projects.ConclusionsSeveral Japanese-funded projects addressed a wide range of health issues across all six building blocks of the health system in Vietnam. However, there is room for improvement in developing coordination and harmonization among the Japanese projects that are diversifying. Furthermore, establishing a target-country-specific mechanism for strategic coordination across Japanese ministries’ schemes can yield efficient and effective development cooperation for health. Our analytic approach using the recategorized six building blocks contributes to a more comprehensive understanding of efforts on strengthening the health system.
LA3CK Score for Predicting in-Hospital Mortality after Minor Bleeding in Patients with Atrial Fibrillation
Authors: Bai Ying , Liu Xin-Yao , Zou Yi-Xi , Guo Shi-Dong , Wang Zhen-Zhou , Shi Xu-Bo , Zhong Peng , Chang Jing , Sun Yu-Feng 
Published: February 2021

Abstract
Backgrounds and Purposes Minor bleeding was found to be closely related with death in in-hospital patients with atrial fibrillation (AF）and the factors affecting mortality after minor bleedings were then explored.Methods This study was divided into two parts. First, 15219 AF patients without major bleeding were included at their first hospitalizations from our centers since 2008 to 2018 to explore the association of minor bleeding with in-hospital mortality. Then factors related with in-hospital death were further explored in 789 AF patients with minor bleeding but without major bleeding and joined into one score predicting mortality after the minor bleedings during hospital stay.Results Patients with minor bleedings were at high risk of mortality (Adjusted OR:4.61, 95% CI: 3.77-5.65, p<0.001), especially if they were older (Adjusted OR:1.05, 95% CI: 1.03-1.06, p<0.001), or complicated with chronic lung diseases, chronic kidney disease stage III-V, anemia, malignant tumor, acute myocardial infarction. The c-index was 0.681 using ROC curve when these risk factors were joined into the score LA3CK. The c-index was 0.81 when this score was extended to the whole in-hospital AF population.Conclusions In the in-hospital AF patients, risk of mortality increased in patients with minor bleeding. The score LA3CK score had a good efficiency in predicting in-hospital mortality after minor bleedings.
Long-Term Outcome of Anti-Vascular Endothelial Growth Factor Therapy Following Vitrectomy for Submacular and/or Vitreous Hemorrhage in Neovascular Age-Related Macular Degeneration
Authors: Kawakami Setsuko , Wakabayashi Yoshihiro , Umazume Kazuhiko , Usui Yoshihiko , Muramatsu Daisuke , Agawa Tsuyoshi , Yamamoto Kaori , Goto Hiroshi 
Published: February 2021

Abstract
Purpose: To study long-term clinical outcomes in patients with submacular hemorrhage (SMH) and/or vitreous hemorrhage (VH) associated with neovascular age-related macular degeneration (nAMD), who received pars plana vitrectomy (PPV) followed by anti-vascular endothelial growth factor (VEGF) therapy.Methods: In this retrospective case series, 25 eyes with SMH and/or VH associated with nAMD were treated by PPV and followed for at least 24 months. When exudative changes were unresolved or recurred after PPV, additional intravitreal anti-VEGF therapy was given. Results:Mean best-corrected visual acuity (BCVA) of all patients improved significantly at 1, 3, 6, 12, 18 and 24 months (P<0.01) post-PPV and at the final visit (P<0.05). Mean BCVA of 13 eyes with anti-VEGF therapy improved significantly at 1 (P<0.05), 3, 6, 12 (P<0.01), 18 and 24 months (P<0.05), while 12 eyes without anti-VEGF therapy improved at 1, 3 and 6 months (P<0.05) only. Average duration from initial PPV to anti-VEGF therapy initiation was 7.54±9.9 months. Five of 13 eyes (38.5%) with anti-VEGF therapy maintained dry macula for more than 1 year after the last injection. Conclusions:　In patients with SMH and VH caused by nAMD, administering intravitreal anti-VEGF therapy when exudative changes are unresolved or recur after PPV maintains improved visual acuity long term.
Analysis of Gaps in Feline Ectoparasiticide Purchases from Veterinary Clinics in the United States.
Authors: Lavan Robert Philip , Normile Dorothy , Husain Imran , Singh Amita , Heaney Kathleen 
Published: February 2021

Abstract
Background:The study objective was to examine cat owner ectoparasiticide purchases in the United States and estimate the impact of purchase gaps on timely ectoparasite protection administration. These purchase gaps lead to periods of time when cats are unprotected from ectoparasites. Methods:Ectoparasiticide purchase transactions for individual cats from 671 U.S. veterinary clinics from January 1, 2017 through June 30, 2019 were evaluated to determine time “gaps” between doses of ectoparasiticides purchased in a defined 12-month period. Ectoparasiticides examined were topically applied products that contained fluralaner, fipronil/(S)-methoprene/pyriproxyfen, imidacloprid/pyriproxyfen or selamectin as active ingredients. The duration of protection following administration of one dose was 12 weeks for the fluralaner-containing product and one month for the other products.Results:Ectoparasiticide purchase records were obtained from 114,853 cat owners and analysis found that most owners bought < 6 months of protection during the year, with 61-75% (depending on the product) purchasing just 1-3 months of protection. The size of the average purchase gap was determined for all dose combinations out to 12 months of protection (5 doses for fluralaner and 12 doses for the other three monthly products. The largest gaps occurred between the first and second doses and the second and third doses. Average purchase gaps for the four different products between doses 1 and 2 ranged from 11.2 - 13.9 weeks and between doses 2 and 3 ranged from 7.7- 12.2 weeks. The fraction of purchases separated by gaps and the average length of the gap tended to decrease with increasing number of doses purchased. Owners purchasing the 12-week duration product containing fluralaner provided ectoparasite protection (“doses plus gap period”) for a larger proportion of each 2-dose period compared with owners purchasing products administered monthly. Conclusions: When cat owners purchase flea and tick medication, gaps between subsequent purchases reduces the proportion of time ectoparasite protection can be provided. The duration of the gap between dose has an impact on the effectiveness of flea/tick medication because it inserts a period without flea and tick protection between doses of flea and tick medication. The gaps between purchases were shorter and the period of ectoparasite protection was larger for owners purchasing a 12-week product than for owners purchasing a monthly product.
A High Degree of Knee Flexion after TKA Promotes the Ability to Perform High-Flexion Activities and Patient Satisfaction in Asian Population
Authors: Han Hyuksoo , Kim Jong Seop , Lee Bora , Won Sungho , Lee Myung Chul 
Published: February 2021

Abstract
Background: This study investigated whether achieving a higher degree of knee flexion after TKA promoted the ability to perform high-flexion activities, as well as patient satisfaction and quality of life.Methods: Clinical data on 912 consecutive primary TKA cases involving a single high-flexion posterior stabilized fixed-bearing prosthesis were retrospectively analyzed. Demographic and clinical data were collected, including knee flexion angle, the ability to perform high-flexion activities, and patient satisfaction and quality of life.Results: Of the cases, 619 (68%) achieved > 130° of knee flexion after TKA (high flexion group). Knee flexion angle and clinical scores showed significant annual changes, with the maximum improvement seen at 5 years and slight deterioration observed at 10 years postoperatively. In the high flexion group, more than 50% of the patients could not kneel or squat, and 35% could not stand up from on the floor. Multivariate analysis revealed that > 130° of knee flexion, the ability to perform high-flexion activities (sitting cross-legged and standing up from the floor), male gender, and bilateral TKA were significantly associated with patient satisfaction after TKA, while the ability to perform high-flexion activities (sitting cross-legged and standing up from the floor), male gender, and bilateral TKA were significantly associated with patient quality of life after TKA.Conclusions: High flexion (> 130°) after TKA increased the ease of high-flexion activities and patient satisfaction. The ease of high-flexion activities also increased quality of life after TKA in our Asian patients, who frequently engage in these activities in daily life.
Risk Factors of Opioid use Associated with an Enhanced-Recovery Programme after Total Knee Arthroplasty
Authors: Cao Guorui , Pei Fuxing 
Published: February 2021

Abstract
Background: The relationship between total knee arthroplasty (TKA) and postoperative opioid use is poorly studied. The aim of the study is to examine the prevalence and risk factors for opioid use with an enhanced-recovery programme after primary TKA.Methods: We identified 361 patients undergoing TKA, and separated those on the basis of whether to receive opioid use after surgery. Multivariate logistic regression model was used to identify independent risk factors for opioid use after primary TKA. Length of stay (LOS) and postoperative complications were recorded and compared.Results: The prevalence of opioid use after primary TKA was 23.0%. Significant risk factor were more operative time (OR [odds ratio] = 1.017, 95% CI [confidence interval] = 1.001 to 1.032, p = 0.034) and protective factor was tranexamic acid use (OR= 0.355, 95% CI = 0.161 to 0.780, p = 0.010). In addition, the LOS was longer in opioid group (p < 0.05).Conclusion: Considering the adverse health effects of opioid use, strategies need to be developed to prevent persistent opioid use. Reducing operative time and application of tranexamic acid could lower the risk of opioid use with an enhanced-recovery programme after primary TKA.
One Ring to Revascularize Them All: Assessing The End Results of Coronary Bioresorbable Vascular Scaffolds as Revascularization Approach for Chronic Total Occlusions
Authors: Wulandari Prima Hapsari 
Published: February 2021

Abstract
Following the era of percutaneous coronary intervention (PCI), the occurrence of revascularization in chronic total occlusions (CTO) is correlated with positive and longstanding echocardiographic and clinical outcomes. The beneficial outcomes of bioresorbable vascular scaffolds (BVS) treatment to manage CTO are currently inconclusive, since patients presenting with CTO were frequently ruled out from a vast number of randomized clinical trials (RCTs) which assess BVS. This systematic review is aimed to review and recapitulate available reports on the clinical outcomes of CTO with BVS treatment. Available data in the Cochrane Library, EMBASE, MEDLINE, and, clinicaltrials.gov are being examined to gather investigations on BVS-treated CTO. Outcomes of concern involved vessel restenosis, scaffold thrombosis, target lesion revascularization, myocardial infarction, major adverse cardiac events (MACE), and all-cause mortality. Thirteen papers have met the criteria for inclusion. All papers were written based on observational studies cumulative population samples of 1,077. Two papers were found to involve retrospective comparison of drug-eluting stents (DES) group with BVS group. The investigations had varying group size and duration of follow-up. This review presented beneficial results for BVS-treated CTO. In double-arm studies, the recorded MACE incidence diverged from 0% to 6.7% with no notable differences between DES and BVS populations. While reports on the implantation of the first-generation BVS in CTO populations are infrequent and recruited only insufficient observational studies samples, the available data is promising. The data shows satisfactory results which are analogous to second-generation DES. However, additional investigation by means of RCTs and the application of more novel scaffolds is necessitated.
Pedestrians in Iran: Determinants of unsafe traffic behaviors of pedestrians
Authors: Aghdam Fatemeh Bakhtari , Bazargani Homayoyn Sadeghi , Sarbakhsh Parvin , Pashaie Tahere , Ponnet Koen , Nicknejad Maryam 
Published: February 2021

Abstract
Objective: Pedestrians are among the most vulnerable groups in traffic accidents. In this cross-sectional study, the behavior of 600 pedestrians in Iran, using a pedestrian traffic behavior questionnaire. Cluster sampling was conducted among 30% of the health centers in each district of the city. Thereafter, individuals were randomly selected from each center depending on the covered population. Results: Although 17% of the pedestrians demonstrated safe traffic behaviors, over 85% were distracted, more than 80% did not comply with traffic laws, the majority violated rules and displayed no positive traffic behaviors, and half of the participants were aggressive. Age, gender, marital status, education level, daily walking rate, and transportation mode were significant predictors of traffic behavior.
Análise comparativa de técnicas de escaneamento digital: estudo in vitro
Authors: Cechelero Eduarda Bianchini , Bellan Mariá Cortina , Bisi Maurício André 
Published: February 2021

Objetivos: O presente estudo tem como objetivo avaliar e comparar a técnica recomendada pelo fabricante e uma técnica de variação padrão de dois scanners intraorais em relação a um escaneamento com um scanner de mesa e analisar a possibilidade de alteração dimensional. Materiais e Métodos: Foram confeccionados 5 grupos (n=5), sendo o G=1 com AutoScan-DS-EX sendo fluxo de trabalho automático, G=2 com TRIOS 3 e técnica recomendada pelo fabricante, G=3 com TRIOS 3 e técnica modificada, G=4 com iTero e técnica recomendada pelo fabricante e G=5 com iTero e técnica modificada, e foram submetidos a uma análise qualitativa de cor pelo software CloudCompare. Resultados: Foi presente bastante alteração dimensional entre os Grupos 2 e 3, 4 e 5, pouca alteração dimensional entre os Grupos 1 e 3, 1 e 5, e nenhuma alteração dimensional entre os Grupos 1 e 2, e 1 e 4. Conclusão: Conclui-se que a modificação da técnica recomendada pelo fabricante altera o padrão final do modelo digitalizado principalmente entre os scanners intraorais, sendo que houve pouca alteração quando as técnicas foram comparadas com um scanner de bancada. A qualidade dos escaneamentos se baseia na quantidade de pontos coletados apresentando-se maior nos escaneamentos com scanner de mesa.
Application of boron-doped diamond, Ti/IrO2, and Ti/Pt anodes for the electrochemical oxidation of landfill leachate biologically pretreated by moving bed biofilm reactor
Authors: Bagastyo Arseto Yekti , Hidayati Arum Sofiana , Herumurti Welly , Nurhayati Ervin 
Published: February 2021

Abstract
Conventional biological treatments used in most Indonesian landfill sites are mostly ineffective in treating stabilized landfill leachates to meet the standard regulation. Thus, a combination of biological and electrochemical process is offered to successfully treat leachates containing a high concentration of organic and nitrogenous compounds. In this study, a moving bed biofilm reactor (MBBR) was applied prior to electrochemical oxidation by using boron-doped diamond (BDD), Ti/IrO2, and Ti/Pt anodes with applied current of 350, 400 and 450 mA. The objectives were to investigate the effect of anode type and the applied current on the removal of organics as well as total nitrogen from the MBBR-treated leachate with electrochemical oxidation. The optimum removal of chemical oxygen demand (COD) observed on the Ti/Pt anode was 78% by applying 400 mA, with an estimated energy of 56.7 Wh g L–1. In the case of Ti/IrO2 and BDD anodes, the optimum removal of COD was 76 and 85% with an energy consumption of 58.9 and 36.9 Wh g L–1, respectively, both achieved at 350 mA. Although all anodes showed less-satisfactory performances for total nitrogen reduction, around 46–95% removal of nitrogenous compounds was achieved by MBBR, with their partial conversion to nitrates.