bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome
Authors: Rolles Benjamin , Wessels Inga , Doukas Panagiotis , Kotelis Drosos , Rink Lothar , Vieri Margherita , Beier Fabian , Jacobs Michael , Gombert Alexander 
Published: December 2021

AbstractThoracoabdominal aortic aneurysm (TAAA) repair is related to a relevant morbidity and in-hospital mortality rate. In this retrospective observational single-center study including serum zinc levels of 33 patients we investigated the relationship between zinc and patients’ outcome following TAAA repair. Six patients died during the hospital stay (18%). These patients showed significantly decreased zinc levels before the intervention (zinc levels before intervention: 60.09 µg/dl [survivors] vs. 45.92 µg/dl [non-survivors]). The post-interventional intensive care SOFA-score (Sepsis-related organ failure assessment) (at day 2) as well as the SAPS (Simplified Acute Physiology Score) (at day 2) showed higher score points in case of low pre-interventional zinc levels. No significant correlation between patient comorbidities and zinc level before intervention, except for peripheral arterial disease (PAD), which was significantly correlated to reduced baseline zinc levels, was observed. Septic shock, pneumonia and urinary tract infections were not associated to reduced zinc levels preoperatively as well as during therapy. Patients with adverse outcome after TAAA repair showed reduced pre-interventional zinc levels. We speculate that decreased zinc levels before intervention may be related to a poorer outcome because of poorer physical status as well as negatively altered perioperative inflammatory response.
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Authors: Li Jianfeng , Garavaglia Silvia , Ye Zhaofeng , Moretti Andrea , Belyaeva Olga V. , Beiser Alison , Ibrahim Md , Wilk Anna , McClellan Steve , Klyuyeva Alla V. , Goggans Kelli R. , Kedishvili Natalia Y. , Salter E. Alan , Wierzbicki Andrzej , Migaud Marie E. , Mullett Steven J. , Yates Nathan A. , Camacho Carlos J. , Rizzi Menico , Sobol Robert W. 
Published: December 2021

AbstractElevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent, and selective inhibitors of key ALDH enzymes may represent a novel CSC-directed treatment paradigm for ALDH+ cancer types. Of the many ALDH isoforms, we and others have implicated the elevated expression of ALDH1A3 in mesenchymal glioma stem cells (MES GSCs) as a target for the development of novel therapeutics. To this end, our structure of human ALDH1A3 combined with in silico modeling identifies a selective, active-site inhibitor of ALDH1A3. The lead compound, MCI-INI-3, is a selective competitive inhibitor of human ALDH1A3 and shows poor inhibitory effect on the structurally related isoform ALDH1A1. Mass spectrometry-based cellular thermal shift analysis reveals that ALDH1A3 is the primary binding protein for MCI-INI-3 in MES GSC lysates. The inhibitory effect of MCI-INI-3 on retinoic acid biosynthesis is comparable with that of ALDH1A3 knockout, suggesting that effective inhibition of ALDH1A3 is achieved with MCI-INI-3. Further development is warranted to characterize the role of ALDH1A3 and retinoic acid biosynthesis in glioma stem cell growth and differentiation.
Neutrino physics with an opaque detector
Authors:   LiquidO Consortium, Cabrera A. , Abusleme A. , dos Anjos J. , Bezerra T. J. C. , Bongrand M. , Bourgeois C. , Breton D. , Buck C. , Busto J. , Calvo E. , Chauveau E. , Chen M. , Chimenti P. , Dal Corso F. , De Conto G. , Dusini S. , Fiorentini G. , Martins C. Frigerio , Givaudan A. , Govoni P. , Gramlich B. , Grassi M. , Han Y. , Hartnell J. , Hugon C. , Jiménez S. , de Kerret H. , Le Nevé A. , Loaiza P. , Maalmi J. , Mantovani F. , Manzanillas L. , Marquet C. , Martino J. , Navas-Nicolás D. , Nunokawa H. , Obolensky M. , Ochoa-Ricoux J. P. , Ortona G. , Palomares C. , Pessina F. , Pin A. , Porter J. C. C. , Pravikoff M. S. , Roche M. , Roskovec B. , Roy N. , Santos C. , Schoppmann S. , Serafini A. , Simard L. , Sisti M. , Stanco L. , Strati V. , Stutzmann J.-S. , Suekane F. , Verdugo A. , Viaud B. , Volpe C. , Vrignon C. , Wagner S. , Yermia F. 
Published: December 2021

AbstractIn 1956 Reines & Cowan discovered the neutrino using a liquid scintillator detector. The neutrinos interacted with the scintillator, producing light that propagated across transparent volumes to surrounding photo-sensors. This approach has remained one of the most widespread and successful neutrino detection technologies used since. This article introduces a concept that breaks with the conventional paradigm of transparency by confining and collecting light near its creation point with an opaque scintillator and a dense array of optical fibres. This technique, called LiquidO, can provide high-resolution imaging to enable efficient identification of individual particles event-by-event. A natural affinity for adding dopants at high concentrations is provided by the use of an opaque medium. With these and other capabilities, the potential of our detector concept to unlock opportunities in neutrino physics is presented here, alongside the results of the first experimental validation.
Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics
Authors: De Saedeleer Bianca , Malabirade Antoine , Ramiro-Garcia Javier , Habier Janine , Trezzi Jean-Pierre , Peters Samantha L , Daujeumont Annegrät , Halder Rashi , Jäger Christian , Busi Susheel Bhanu , May Patrick , Oertel Wolfgang , Mollenhauer Brit , Laczny Cédric C , Hettich Robert L , Wilmes Paul 
Published: December 2021

Abstract
The human gut microbiome produces a complex mixture of biomolecules that interact with human physiology and play essential roles in health and disease. Crosstalk between micro-organisms and host cells is enabled by different direct contacts, but also by the export of molecules through secretion systems and extracellular vesicles. The resulting molecular network, comprised of various biomolecular moieties, has so far eluded systematic study. Here we present a methodological framework, optimized for the extraction of the microbiome-derived, extracellular biomolecular complement, including nucleic acids, (poly)peptides, and metabolites, from flash-frozen stool samples of healthy human individuals. Our method allows simultaneous isolation of individual biomolecular fractions from the same original stool sample, followed by specialized omic analyses. The resulting multi-omics data enable coherent data integration for the systematic characterization of this molecular complex. Our results demonstrate the distinctiveness of the different extracellular biomolecular fractions, both in terms of their taxonomic and functional composition. This highlights the challenge of inferring the extracellular biomolecular complement of the gut microbiome based on single-omic data. The developed methodological framework provides the foundation for systematically investigating mechanistic links between microbiome-secreted molecules, including those that are typically vesicle-associated, and their impact on host physiology in health and disease.
Effects of Cued and Uncued Swallowing in Patients With Dementia
Authors: Guastella Rebekah , Oppedisano Stefania , Riquelme Luis F. , Namasivayam-MacDonald Ashwini M. 
Published: December 2021

Purpose:
Parameters such as bolus location at swallow onset (BLSO), stage transition duration (STD), pharyngeal transition duration (PTD), pharyngeal response duration (PRD), and pharyngeal phase duration (PPD) often vary between cued and uncued swallowing conditions. Research has demonstrated that cued swallows may offer functional benefits that mitigate pathophysiological processes. However, there are limited data assessing differences between cued and uncued swallows in disordered populations, such as dementia. The purpose of this study was to evaluate if cued swallowing alters swallowing biomechanics in patients living with dementia.

Method:

Through a retrospective analysis of videofluoroscopic swallow studies (VFSS), 105 swallows from 26 participants living with dementia (
M
age
= 81 years; 14 women) were analyzed in duplicate by blinded raters using the Analysis of Swallowing Physiology, Events, Kinematics, and Timing method. Only VFSS with at least one cued and one uncued swallow were included in the analysis. Chi-square tests were used to explore differences in BLSO. Repeated-measures analyses of variance (ANOVAs) were used to explore differences in STD, PTD, PRD, and PPD.

Results:

Results revealed no significant differences in BLSO between cued and uncued swallows for patients living with dementia (
p
= .934). Repeated-measures ANOVAs revealed no significant differences between the two types of swallows for STD (
p
= .995), PTD (
p
= .864), PRD (
p
= .807), or PPD (
p
= .660).

Conclusions:
This study suggests that there may be limited benefit to providing cued swallows to individuals living with dementia. Further research should investigate if this is due to impaired cognition and/or changes in motor control to volitionally complete the cued swallow.
High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report
Authors: Santiago Aline Evangelista , Teunissen Nicky , Ricardo Bernardo Ferreira de Paula , Cândido Eduardo Batista , Furtado Rafaela de Souza , Silva Filho Agnaldo Lopes da 
Published: December 2021

Abstract
Introduction In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors.
Case Report A 77-year-old woman with a non-ulcerated vulvar lesion on the topography of the right Bartholin gland. The patient was submitted to tumor resection followed by V–Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy.
Conclusion As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness.
Analysis of the Role of Female Hormones During Infection by COVID-19
Authors: Pascoal David Balbino , Araujo Isabela Macêdo de , Lopes Lorenna Peixoto , Cruz Cristiane Monteiro da 
Published: December 2021

AbstractWomen have metabolic, immunological, and genetic variables that ensure more protection from coronavirus infection. However, the indication of treatment for several pathologies and contraception is determined by hormones that have adverse effects and raise doubts about their use during the COVID-19 pandemic. Therefore, the present study searches women specificities and the relation between female sexual hormones and COVID-19, and reports the main recommendations in this background. To this end, a review of the literature was conducted in the main databases, auxiliary data sources, and official websites. Therefore, considering the hypercoagulability status of COVID-19, the debate about the use of contraceptives due to the relative risk of thromboembolic effects that they impose arises. However, the current available evidence, as well as the recommendations of main health organs around the world, demonstrate that the use of hormonal contraceptives must be maintained during the pandemic.
Expansion by migration and diffusion by contact is a source to the global diversity of linguistic nominal categorization systems
Authors: Allassonnière-Tang Marc , Lundgren Olof , Robbers Maja , Cronhamn Sandra , Larsson Filip , Her One-Soon , Hammarström Harald , Carling Gerd 
Published: December 2021

AbstractLanguages of diverse structures and different families tend to share common patterns if they are spoken in geographic proximity. This convergence is often explained by horizontal diffusibility, which is typically ascribed to language contact. In such a scenario, speakers of two or more languages interact and influence each other’s languages, and in this interaction, more grammaticalized features tend to be more resistant to diffusion compared to features of more lexical content. An alternative explanation is vertical heritability: languages in proximity often share genealogical descent. Here, we suggest that the geographic distribution of features globally can be explained by two major pathways, which are generally not distinguished within quantitative typological models: feature diffusion and language expansion. The first pathway corresponds to the contact scenario described above, while the second occurs when speakers of genetically related languages migrate. We take the worldwide distribution of nominal classification systems (grammatical gender, noun class, and classifier) as a case study to show that more grammaticalized systems, such as gender, and less grammaticalized systems, such as classifiers, are almost equally widespread, but the former spread more by language expansion historically, whereas the latter spread more by feature diffusion. Our results indicate that quantitative models measuring the areal diffusibility and stability of linguistic features are likely to be affected by language expansion that occurs by historical coincidence. We anticipate that our findings will support studies of language diversity in a more sophisticated way, with relevance to other parts of language, such as phonology.
A multidisciplinary approach to evaluate the impact of emotional dysregulation on adolescent decision making
Authors: Weinrabe Angé , Hickie Ian B. 
Published: December 2021

AbstractEvaluating decision-making during youth is a complex area of research. Multiple factors influence the young person’s subjective decision-making at this stage of development. Sub-optimal decision-making can have lifelong consequences. Longer adolescence, life stressors, drugs and alcohol and adverse events impact the young person, making them vulnerable to emerging mood disorders, such as anxiety and depression. Behavioural economics with its cognitive and multidisciplinary approach examines decision-making in youth with emerging mood disorders, but few empirical studies exist outside of a laboratory setting. Of the few that apply a multidisciplinary approach, most focus on other mental disorders. This review qualitatively evaluates the decision science literature to firstly, investigate complex factors influencing decision-making between adolescence and young adulthood. Secondly, it investigates studies that have applied either a cognitive or multidisciplinary approach to evaluate how young people choose. With respect to the studies identified, this review found that as opposed to depression, clinical anxiety (trait) and its relationship to youth decision-making has not been well researched using the multidisciplinary approach. Studies that did apply this approach found that mood disordered young individuals overall performed worse than healthy controls. This review argues that applying the multidisciplinary approach to study subjective decision-making can provide an alternative measure to empirically evaluate early stages of psychopathology in a youth population. Investigating the critical time points where the decision process itself impacts affective states in individuals could further elucidate some of the challenges currently faced in decision-making studies.
Effects of methionine as free amino acid and dipeptide on productive efficiency and meat quality of broilers under acute and chronic heat stress
Authors: de Sousa Fabiana Cristina Belchior , Del Vesco Ana Paula , Zancanela Vittor , Santana Thais Pacheco , de Souza Khatlab Angélica , Feitosa Víctor Emanuel Meneses , Brito Claudson Oliveira , Barbosa Leandro Teixeira , Gasparino Eliane 
Published: December 2021

Context Methionine in the form of free amino acid has been widely studied in broilers challenged by heat stress (HS). However, the effects of methionine dipeptide in broilers subjected to HS are not known. Aims To evaluate the effects of methionine as free amino acid and dipeptide on the performance, oxidative status, plasma parameters and meat quality of broilers subjected to acute and chronic HS. Methods Broilers were evaluated at the following three experimental periods: 24 h of evaluation (21–22 days of age); 10 days of evaluation (22–32 days of age); and 20 days of evaluation (22–42 days of age). Broilers were divided into two groups; one group was raised in thermal comfort, and the other group was raised in continuous HS of 30°C. In both groups, animals received a diet without methionine supplementation (MD), with supplementation of methionine as free amino acid (dl-M), and with supplementation of methionine as dipeptide (dl-MM). Key results HS reduced body weight gain after 10 and 20 days of evaluation. Broilers under HS condition fed the MD diet had the highest concentrations of thiobarbituric acid reactive substances (TBARS) at 22 days of age and carbonylated proteins (CP) at 32 days of age. At 42 days of age, broilers fed the MD diet had higher concentrations of TBARS and CP. At 32 days of age, broilers under HS had lower high-density lipoprotein and higher low-density lipoprotein concentrations. In breast meat, broilers in thermal comfort fed the dl-M or dl-MM diets had a lower cooking loss. Broilers in HS fed the dl-M diet had the lowest cooking loss. HS reduced the pH of the meat of legs. Conclusions The acute and chronic HS affect the broiler performance in different ways. Methionine supplementation contributes to reduce the effects of HS. There were no notable differences between the supplementation of dl-M or dl-MM. Implications Productivity and the quality of the chicken meat are the most important attributes of the production. The ambient temperature can influence these parameters. The methionine in its most varied forms, due to its direct and indirect antioxidant function, has been shown to be an effective source of protection for the animal in adverse conditions such as during HS.
Multi-chip front-end electronics LYRA for X and γ Ray detector for HERMES mission
Authors: Gandola M. , Mele F. , Grassi M. , Malcovati P. , Bertuccio G. 
Published: December 2021

Abstract
We present the experimental results of the Application Specific Integrated Circuit (ASIC), called LYRA, specifically designed for the High-Energy Rapid Modular Ensemble of Satellites (HERMES) mission concept, a constellation of nano-satellites able to detect and localize high-energy rapid transient events (up to 2.2 MeV) as the Gamma Ray Bursts (GRBs) from the deep space. LYRA has been desied for the detection system composed by a combination of Gadolinium Aluminum Gallium Garnet (GAGG) scintillators for high-energy photons, coupled to a matrix of 120 silicon drift detectors (SDD), used for detecting both scintillation light and low-energy photons. The LYRA ASIC has been conceived with a multi-chip architecture: 120 LYRA Front-End chips (LYRA-FE) are placed in close proximity to the anodes of the SDD matrix for a first processing of the detector signals and trasmit them in current mode to four 32-channel LYRA Back-End chips (LYRA-BE) to complete the elaboration. The requirements that the LYRA ASIC have to fulfill for the HERMES project are challenging: the maximum input energy measured in Silicon must reach 120 keV — corresponding to 2.2 MeV on GAGG — with a linearity error below 1%, the electronic noise must be less then 30 el. r.m.s. and the power consumption less then 1 mW per channel in a system with 120 channels working in parallel. The characterization of LYRA has been carried out on a dedicated test board, coupling one channel of the ASIC with a 25 mm2 SDD. An input full scale range of 5.2 fC and an electronic noise of 22 el. r.m.s. have been measured at -33∘C with a power consumption of 745 µW per channel.
Design and construction of hardware and software for autonomous observations of Transient Luminous Events
Authors: Amrich S. , Mackovjak Š. , Strhárský I. , Baláž J. , Hančikovský M. 
Published: December 2021

Abstract
Transient luminous events (TLE) are phenomena which are
currently on the rise in terms of sightings. However, there is no
widespread uniform method of their observation and subsequent image
processing. Therefore, our project focuses on the design and
construction of hardware that can record TLE. It consists of a low
gain, colour, CMOS camera with a bright, wide lens connected to a
small, power-efficient single board computer. The project also
includes writing software to control the hardware. The software
decides whether to capture or not and at what orientation there is
the biggest chance to capture a TLE. The software can process and
classify the created photos based on deep neural networks. As a
final product, we have developed the whole apparatus from a hardware
and software point of view and installed it at the Astronomical
Observatory at Kolonica Saddle in Slovakia, Central Europe. The plan
for the future is to make similar apparatuses to spread the
observation network.
Smoke and COVID-19 case fatality ratios during California wildfires
Authors: Schwarz Lara , Dimitrova Anna , Aguilera Rosana , Basu Rupa , Gershunov Alexander , Benmarhnia Tarik 
Published: December 2021

Abstract
Recent evidence has shown an association between wildfire smoke and COVID-19 cases and deaths. The San Francisco Bay Area, in California (USA), experienced two major concurrent public health threats in 2020: the COVID-19 pandemic and dense smoke emitted by wildfires. This provides a unprecedented context to unravel the role of acute air pollution exposure on COVID-19 severity. A smoke product provided by the National Oceanic and Atmospheric Association Hazard Mapping System was used to identify counties exposed to heavy smoke in summer and fall of 2020. Daily COVID-19 cases and deaths for the United States were downloaded at the County-level from the CDC COVID Data Tracker. Synthetic control methods were used to estimate the causal effect of the wildfire smoke on daily COVID-19 case fatality ratios (CFRs), adjusting for population mobility. Evidence of an impact of wildfire smoke on COVID-19 CFRs was observed, with precise estimates in Alameda and San Francisco. Up to 58 (95% CI: 29, 87) additional deaths for every 1000 COVID-19 incident daily cases attributable to wildfire smoke was estimated in Alameda in early September. Findings indicated that extreme weather events such as wildfires smoke can drive increased vulnerability to infectious diseases, highlighting the need to further study these colliding crises. Understanding the environmental drivers of COVID-19 mortality can be used to protect vulnerable populations from these potentially concomitant public health threats.
The

Z2×Z2

-graded Lie superalgebras

pso(2n+1|2n)

and

pso(∞|∞)

, and parastatistics Fock spaces
Authors: Stoilova N I , Van der Jeugt J 
Published: December 2021

Abstract
The parastatistics Fock spaces of order p corresponding to an infinite number of parafermions and parabosons with relative paraboson relations are constructed. The Fock spaces are lowest weight representations of the

Z

2

×

Z

2

-graded Lie superalgebra

p
s
o

(

∞
|
∞

)

, with a basis consisting of row-stable Gelfand–Zetlin patterns.