bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Dynamics of Oxidative Stress Indicators and Early Markers of Myocardial Damage and Dysfunction in Patients with Aggressive Lymphoproliferative Diseases During of Anticancer Therapy
Authors: Antyufeeva O. N. , Budanova D. A. , Ilgisonis I. S. , Gadaev I. Yu. , Bochkarnikova O. V. , Sokolova I. Ya. , Belenkov Yu. N. , Ershov V. I. 
Published: February 2021

Aim To evaluate the dynamics of indexes of oxidative stress and markers of myocardial injury and dysfunction in patients with aggressive type lymphomas during the antitumor therapy.Material and methods This study included 75 patients with lymphoproliferative diseases of aggressive type. The main group consisted of 53 patients who received one course of antitumor therapy during the study. The comparison group consisted of 22 patients who have not received any specific treatment so far. Troponin I (TnI), high-sensitivity troponin (hsTnI), heart-type fatty acid binding protein (Н-FAВР), N-terminal pro-brain natriuretic peptide (NT-prоBNP), superoxide dismutase (SOD), and myeloperoxidase (MPO) were measured in patients of both groups at baseline, and in the main group, they were measured at 4 hours after administration of antitumor agents and on completion of the course. Functional status of the cardiovascular system was evaluated by electrocardiography in all patients at baseline and after the course of antitumor treatment and by echocardiography.Results The chemotherapy was associated with increased levels of NT-prоBNP, SOD, and MPO (30.670±15.367 vs. 52.309±25.718 pmo l/l; 1.61±0.135 vs. 1.74±0.193 U/ml; and 507.54±91.51 vs. 742.3±49.01 ng/ml, respectively). The study results indicated activation of oxidative stress on the background of the administered antitumor therapy, progressive myocardial dysfunction, and increased frequency of arrhythmic episodes.Conclusion The study results allowed identifying NT-prоBNP, MPO, and SOD as important indexes for determining a patient group at high risk of cardiotoxicity during the antitumor treatment.
“If the river comes to an end, the community comes to an end”: pedagogical dimension of environmental racism
Authors: Melo André Carneiro , Barzano Marco Antonio Leandro 
Published: February 2021

This article aims to analyze the educational practices that emerge from conflict situations in which ancestry and the right to the quilombola territory are appreciated. From the narratives of the residents of the Barreiros de Itaguaçu community with regard to the conditions of retrenchment of their traditional territory, we wanted to contribute—through the production of knowledge about the environmental racism experienced by the community—with the hope of increasing its visibility in places where the different axes ofcoloniality do not allow it. Living together within the community revealed that the residents create resistance strategies to fight the process of occupation of their territory. This idea of resistance that we describe here is not limited exclusively to the defense of the territory, it also refers to the defense of the ways of survival and to the defense of the community way of life, which evinces the quilombola identity. This context of community resistance is considered as a universe of tensions and diverse problems engendered by the worldwide colonial system, based on the different faces of coloniality, from where the quilombolacommunity-produced knowledges emerge, which query other ways of appropriating nature.
El velocipedismo/ciclismo en La Rioja en el siglo XIX: sobre el origen e historia de las sociedades Veloz Club Riojano de Logroño y Club Velocipedista Harense = The Velocipedism/Cyclism in La Rioja during the 19th Century: on the origin and history of the Veloz Club Riojano from Logroño and Club Velocipedista Harense societies
Authors: Mota Zurdo David 
Published: February 2021

El análisis de la historia del deporte en La Rioja es hoy en día un terreno insuficientemente explorado. Hasta hace relativamente poco tiempo el conocimiento que se tenía en esta región sobre disciplinas deportivas como el velocipedismo era bastante exiguo, señalándose fundamentalmente que se trató de un deporte muy subsidiario, con apenas apoyo y seguidores. Las fuentes revelan que no fue exactamente así. Por eso, con este artículo se pretende desmitificar aquellas aseveraciones que han colocado a la velocipedia en un plano muy secundario, mostrando para ello que ésta tuvo un significativo arraigo en dos ciudades riojanas de primer orden: Logroño y Haro. Así, tras realizar un somero repaso de la trayectoria del deporte a nivel europeo y español, se pasa a estudiarlo tomando a La Rioja como referente, para finalmente analizar en perspectiva comparada dos de las entidades velocipédicas riojanas más destacables del siglo XIX: Veloz Club Riojano y Club Velocipedista Harense. AbstractToday the analysis of the history of sport in La Rioja is a ground of pioneers. Until recently, the knowledge in this region about sports disciplines such as velocipedism was quite meager. Nevertheless, the access to ancient press sources lets know in a greater depth the first steps of the Rioja velocipedism. Therefore, this article aims to stimulate the knowledge about the Rioja cyclism history through the studying of two main cities: Logroño and Haro. Subsequently, after conducting a brief review of the trajectory of Sport in Spain and Rioja, it is analyzed two of the most outstanding Riojan velocipedic entities of the 19th century: Veloz Club Riojano and Club Velocipedista Harense.
Mitochondrial Calcification
Authors: Duvvuri Bhargavi , Lood Christian 
Published: February 2021

Abstract
One of the most fascinating aspects of mitochondria is their remarkable ability to accumulate and store large amounts of calcium in the presence of phosphate leading to mitochondrial calcification. In this paper, we briefly address the mechanisms that regulate mitochondrial calcium homeostasis followed by the extensive review on the formation and characterization of intramitochondrial calcium phosphate granules leading to mitochondrial calcification and its relevance to physiological and pathological calcifications of body tissues.
Responsiveness, Reliability, and Validity of Arabic Version of Oxford Knee Score for Total Knee Arthroplasty
Authors: Bin Sheeha Bodor , Williams Anita , Johnson David Sands , Granat Malcolm , Bin Nasser Ahmad , Jones Richard 
Published: February 2021

Background:
The Oxford Knee Score (OKS) is a reliable, valid, and sensitive assessment tool for individuals undergoing a total knee arthroplasty (TKA). The published psychometric assessment of the Arabic version of the OKS (OKS-Ar) is limited to male patients and has not been assessed for responsiveness following TKA. The aim of this study was to assess the reliability, validity, and responsiveness of the OKS-Ar in an inclusive population of patients undergoing TKA.

Methods:
One hundred Arabic-speaking patients awaiting TKA were assessed with the OKS-Ar, the Arabic version of the Knee injury and Osteoarthritis Outcome Score (KOOS-Ar), and a visual analogue scale for pain (VAS-P) in order to assess the correlation between the OKS-Ar and the KOOS-Ar and VAS-P and determine the construct validity. Repeat assessments were completed 7 to 10 days after the first assessment and 6 months after TKA.

Results:
Questionnaires were completed by 80 female and 20 male participants with a mean age of 62 ± 8 years. The test and retest median scores showed no significant difference from one another, with a strong Spearman correlation between the 2 measurements (rs = 0.94). Bland-Altman limits of agreement showed no significant bias. The Cronbach alpha was 0.85 indicating high internal consistency. There was no floor or ceiling effect before TKA, and the post-TKA ceiling effect was only 2%. The OKS-Ar pain component correlated strongly with the KOOS-Ar pain subscale (rs = 0.73). The OKS-Ar effect size was 3.09, which was larger than that of all of the KOOS subscales at 6 months after TKA.

Conclusions:
To our knowledge, this is the first study to assess reliability, validity, and responsiveness of the OKS-Ar after TKA. The validity and reliability results are similar to those found for both the original English-language OKS and the OKS translated into other languages. We believe that this is also the first study to assess OKS-Ar responsiveness after TKA and to show a large effect size. We found that the OKS-Ar is a feasible, valid, reliable, and sensitive measurement tool to assess pain and function in TKA-treated individuals whose main language is Arabic.
Trend and equity of general practitioners’ allocation in China Based on the Data from 2012-2017
Authors: Yu Qianqian , Yin Wenqiang , Huang Dongmei , Sun Kui , Chen Zhongming , Guo Hongwei , Wu Di 
Published: February 2021

Abstract
Background: General practitioners are the gatekeepers of the health of the residents. This study aims to evaluate the trend and equity of general practitioners' allocation from 2012-2017 in China and provide a reference for regional health planning and rational distribution of general practitioners. Methods: We extracted the data of general practitioners from 22 provinces, 5 autonomous regions, and 4 municipalities of mainland China. The population and geographical area were taken from the China Statistical Yearbook. The general practitioners' data were taken from the China Health Statistical Yearbook. Lorenz curve, Gini coefficient, and agglomeration degree were used to analyze the data. Results：The number of general practitioners was 252,717 in 2017, which equates to 1.82 per 10,000 residents, and accounts for 7.45% of the total number of practicing (assistant) doctors. From 2012 to 2017, the population-based Gini coefficient for general practitioners reduced from 0.31 to 0.24, while the geographical area-based Gini coefficient remained unchanged at 0.73. The agglomeration degree based on population increased from 0.72 to 0.73 in the western region including Tibet (0.403) and Shaanxi (0.513). Moreover, in the eastern region the agglomeration degree reduced from 1.477 to 1.329. In the middle region it rose from 0.646 to 0.802. The agglomeration degree based on the geographical area in the western region increased from 0.270 to 0.277 while the values in Tibet, Qinghai, Xinjiang were less than 0.1. In the eastern region, it reduced from 1.447 to 1.329. It increased from 1.149 to 1.423 in the middle region.Conclusions: The number of general practitioners has increased significantly in China. It has a fair allocation based on population. However, the equity based on geographical area is low and uneven in different regions with large regional differences. In the western region, there is an allocation shortage with respect to population and geographical area. Concerned departments should establish and improve the incentive and performance appraisal mechanisms of general practitioners. The Internet+ should be used to empower their service capacity and efficiency. The educational input should be increased for the western region and government should encourage the eastern region to support the western region.
A Qualitative Study on of Psychological Stress Among Frontline Nurses Fighting COVID-19
Authors: Pan Aihong , Wu Yuyan , Chen Juanjuan 
Published: February 2021

Abstract
Objectives To understand the mental health status of frontline nurses who were in direct contact with patients with confirmed or suspected coronavirus disease 2019 (COVID-19) and their tolerance for work duration and work intensity during the COVID epidemic, to identify the greatest source of stress, and to provide a scientific basis for targeted psychological interventions performed by clinical nursing managers to improve nurses' mental health. Methods Using a purposive sampling method, a semistructured interview was conducted with 50 nurses working in the COVID ward, observation ward, and fever clinic of a COVID-19 designated treatment hospital in Hefei City. The interview data were sorted and analyzed using the Colaizzi phenomenological research method. Results The frontline nurses felt stress, anxiety and loneliness, interpersonal distress, and psychological needs and had certain expectations regarding work duration and work intensity. Conclusion Nursing managers should pay attention to the psychological needs of frontline nurses caring for COVID-19 patients, provide targeted intervention measures and make timely adjustments, and create a psychological stress response model for these nurses.
The Effect of Xuebijing on the Gut Microbiota and Metabolic of Heat 1 Stroke Rat 2
Authors: wen Qiang , He Xuan , Shao Yu , Peng Lun , Zhao Li , Pan Guo , Su Lei 
Published: February 2021

Abstract
The goal of the present study was to evaluate the fecal microbiome and serum metabolites in 16 Xuebijing (XBJ)-injected rats after heat stroke using 16S rRNA gene sequencing and gas chromatography-mass spectrometry (GC-MS) metabolomics. Eighteen rats were divided into the control group (CON), heat stroke group (HS), and XBJ group. The 16S rRNA gene sequencing results revealed that the abundance of Bacteroidetes was overrepresented in the XBJ group compared to the HS group, while Actinobacteria was underrepresented. Metabolomic profiling showed that the pyrimidine metabolism pathway, pentose phosphate pathway, and glycerophospholipid metabolism pathway were upregulated in the XBJ group compared to the HS group. Taken together, these results demonstrated that heat stroke not only altered the gut microbiome community structure of rats but also greatly affected metabolic functions, leading to gut microbiome toxicity.
Has the Use of Contraceptive Helped in Averting Births? An Analysis of Births Averted in 21 Major States of India
Authors: Das Jyoti , Singh S.K. , Mahapatra Bidhubhushan 
Published: February 2021

Abstract
Background: In a highly populated country like India, family planning plays a major role in controlling population growth. Estimation of births averted helps in assessing the effectiveness of contraceptive methods. Since the 1950s, different strategies of family planning have been adopted to curb fertility rates by expanding the use of modern contraception among couples. As a result, there has been a steady increase in the users of family planning methods to curb their family sizes. However, there is variation in the adoption of contraceptive methods across the states. From earlier researches, it is established that the permanent modern methods like female sterilization, male sterilization, and IUCD are almost 100 percent effective methods to prevent pregnancy. This study, therefore, is a worthy attempt to estimate the births averted using modern contraception at present for Indian states with the help of the latest available data, by using the method suggested by Liu and others (2008)[11]. Results: The results of the analysis show that births averted were highest in Uttar Pradesh and Maharashtra. However, the percentage reduction in births by the contraceptive method is highest in Punjab indicating the effectiveness of modern contraception use. Conclusions: The analysis of births-averted estimation not only shows the state-level variations but also its significant impact on reducing TFR. Further, female sterilization has the highest prevalence rate among the contraceptive method and averting the highest number of births.
15-Lipoxygenase-2 Deficiency Induces a Dysfunction in Macrophages That Can Be Restored by Salidroside
Authors: Huang Rong Huang , Li Tingting Li , Yong Xi Yong , Wen Huling Wen , Zhou Xing Zhou , Liao Yichen Liao , You Jun You , Yu Chunlei Yu , Xu Peng Xu , Wang Yuquan Wang , Wen Dan Wen , Xia Tianqin Xia , Yang Hao Yang , Chen Yanqin Chen , Xu Lei Xu , Zhong Xiaorong Zhong , Li Xianfu Li , Zhou Chunyang Zhou , Xu Zhengmin Xu 
Published: February 2021

Abstract
15-Lipoxygenase-2(15-LOX-2) is thought to regulate inflammation and immunological function however, its mechanisms of action are still unclear. Furthermore, it has been reported that salidroside has anti inflammatory properties , but its role in macrophage function has not been understood yet In this study, we aimed to determine how 15-LOX-2 expression level s affect the function of macrophages and the effect of salidroside on 15-LOX-2 deficient macrophages We used multiple functional genetic strategies to determine 15-LOX-2 function in macrophages. 15-LOX-2 deficiency promotes phagocytosis and proliferation of macrophages and impairs their apoptosis Mechanistically, t he expression levels of cyclophilinB (CypB) were upregulated in 15-LOX-2 deficient Ana 1 macrophages, whereas those of caspase 3 were down regulated. Furthermore, RNA-seq analysis showed that inflammation, complement, and TNF-α signaling pathway s were all activated in 15-LOX-2 deficient Ana 1 macrophages. Treatment of 15-LOX-2 deficient macrophages with salidroside, a natural product derived from Rhodiola species, effectively reversed the effects of 15-LOX-2 deficiency on caspase 3 and CypB levels, as well as on apoptosis and proliferation. In conclusion, our study shows that there is a newly identified link between 15-LOX-2 deficiency and salidroside in regulating macrophage survival, proliferation, and function. Salidroside may be a promising therapeutic strategy for treating inflammation related diseases resulting from 15-LOX-2 deficiency.
Speech Perception Across The Lifespan by Means of Artificial Intelligence
Authors: Hoppe Ulrich , Hocke Thomas , Iro Heinrich 
Published: February 2021

Abstract
Hearing loss is one of the most common diseases worldwide. It affects communicative abilities in all age groups. However, it is well known that elderly people suffer more frequently from hearing loss. The aim of this study was to describe the relationship between hearing loss, age, and speech perception. The model that we employed used Random Forest Regression. It was applied to a large clinical data set of 19,801 ears, covering all degrees of hearing loss. It allows the estimation of age-related decline in speech perception in quiet, with the effect of pure-tone hearing loss completely separated. Our results show that speech scores depend on the specific type of hearing loss and age. We found age effects for all degrees of hearing loss. A deterioration in speech perception of up to 25 percentage points across the whole life span was observed. The largest decrease was 10 percentage points per life decade. The decline can be attributed to a distortion component of presbyacusis, which is not measured by pure-tone audiometry.
Gender-Specific Associations of Speech-Frequency Hearing Loss, High-Frequency Hearing Loss, and Cognitive Impairment Among Older Community Dwellers in China
Authors: Wang Jingru , Wang Feng , Han Peipei , Liu Yuewen , Ma Weibo , Yu Xing , Xie Fandi , Niu Shumeng , Hu Hao , Zhu Xiaohan , Yu Ying , Guo Qi 
Published: February 2021

Abstract
Objectives

The purpose of this study was to investigate the relationship between speech-frequency hearing loss (SFHL), high-frequency hearing loss (HFHL), and cognitive impairment (CI). Then to determine whether there are any differences in gender among older community dwellers in China.
Methods

This study involved 1,012 adults aged ≥ 60 years (428 male; average age, 72.61 ± 5.51 years). The participants had their hearing and cognition measured using pure tone audiometry and Mini Mental State Examination (MMSE), respectively. We used the audiometric definition of hearing loss (HL) adopted by the World Health Organization (WHO). Speech-frequencies were measured as 0.5 kHz, 1 kHz, 2 kHz, and 4 kHz; high-frequencies were measured as 4 kHz and 8 kHz. Pure tone average (PTA) was measured as hearing sensitivity.
Results

Our studies demonstrated a 37.6% prevalence of HL in males and a 36.0% prevalence of HL in females. Adjusted for confounding variables, the results from a multivariate analysis showed that SFHL was associated with CI in females (OR = 2.400, 95% Confidence Interval = 1.313–4.385) and males (OR = 2.189, 95% Confidence Interval = 0.599–2.944). However, HFHL was associated with CI only in females (OR = 2.943, 95% Confidence Interval = 1.505–5.754). HL was associated with poorer cognitive scores (P < 0.05). “Registration” (P < 0.05) in MMSE was associated with speech- and high-frequency hearing sensitivity.
Conclusion

The associations between HL and CI varied according to gender in older community-dwellers, suggesting that different mechanisms are involved in the etiology of HL. Moreover, hearing sensitivity was negatively associated with cognition scores; therefore, early screening for HL and CI among older community-dwelling adults is advised.
COVID-19/Pneumonia Classification Based on Guided Attention
Authors: Danilov Viacheslav , Karpovsky Alex , Kirpich Alexander , Litmanovich Diana , Nefaridze Dato , Talalov Oleg , Semyonov Semyon , Proutski Alexander , Koniukhovskii Vladimir , Shvartc Vladimir , Gankin Yuriy 
Published: February 2021

Abstract
With the novel coronavirus 19 (COVID-19) continually having a devastating effect around the globe, many scientists and clinicians are actively seeking to develop new techniques to assist with the tackling of this disease. Modern machine learning methods have shown promise in their adoption to assist the health care industry through their data and analytics-driven decision making, inspiring researchers to develop new angles to fight the virus. In this paper, we aim to develop a robust method for the detection of COVID-19 by utilizing patients' chest X-ray images. Despite recent progress, scarcity of data has thus far limited the development of a robust solution. We extend upon existing work by combing publicly available data across 5 different sources and carefully annotating the comprising images into three categories: normal, pneumonia, and COVID-19. To achieve a high classification accuracy, we propose a training pipeline based on the directed guidance of traditional classification networks, where the guidance is directed by an external segmentation network. Through this network, we observed that the widely used, standard networks can achieve an accuracy comparable to tailor-made models specifically for COVID-19, furthermore one network, VGG-16, outperformed the best of the tailor-made models.
Friction law for atomic-scale contact assisted by atomistic simulations
Authors: Wang Yang , Xu Jingxiang , Ootani Yusuke , Ozawa Nobuki , Adachi Koshi , Kubo Momoji 
Published: February 2021

Abstract
Non-empirical law depicting how atomic-scale friction behaves is crucial to facilitate the practical design of tribosystems. However, progress in developing a practically usable friction law has stagnated because atomic-scale friction arises from the continuous forming and rupturing of interfacial chemical bonds and such interfacial chemical reactions are difficult to measure precisely in experiments. Here, we propose a usable friction law for atomic-scale contact by using atomistic simulations to correctly measure the interfacial chemical reactions of a realistic rough surface, and confirm its applicability to predicting how atomic-scale friction varies with temperature, sliding velocity, and load.