bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Ocean Sediment Composition and Burial Flux in the Deep Sea
Authors: Hayes Christopher T. , Costa Kassandra M. , Anderson Robert F. , Calvo Eva , Chase Zanna , Demina Ludmila L. , Dutay Jean‐Claude , German Christopher R. , Heimbürger‐Boavida Lars‐Eric , Jaccard Samuel L. , Jacobel Allison , Kohfeld Karen E. , Kravchishina Marina D. , Lippold Jörg , Mekik Figen , Missiaen Lise , Pavia Frank J. , Paytan Adina , Pedrosa‐Pamies Rut , Petrova Mariia V. , Rahman Shaily , Robinson Laura F. , Roy‐Barman Matthieu , Sanchez‐Vidal Anna , Shiller Alan , Tagliabue Alessandro , Tessin Allyson C. , van Hulten Marco , Zhang Jing 
Published: March 2021

AbstractQuantitative knowledge about the burial of sedimentary components at the seafloor has wide‐ranging implications in ocean science, from global climate to continental weathering. The use of 230Th‐normalized fluxes reduces uncertainties that many prior studies faced by accounting for the effects of sediment redistribution by bottom currents and minimizing the impact of age model uncertainty. Here we employ a recently compiled global data set of 230Th‐normalized fluxes with an updated database of seafloor surface sediment composition to derive atlases of the deep‐sea burial flux of calcium carbonate, biogenic opal, total organic carbon (TOC), nonbiogenic material, iron, mercury, and excess barium (Baxs). The spatial patterns of major component burial are mainly consistent with prior work, but the new quantitative estimates allow evaluations of deep‐sea budgets. Our integrated deep‐sea burial fluxes are 136 Tg C/yr CaCO3, 153 Tg Si/yr opal, 20Tg C/yr TOC, 220 Mg Hg/yr, and 2.6 Tg Baxs/yr. This opal flux is roughly a factor of 2 increase over previous estimates, with important implications for the global Si cycle. Sedimentary Fe fluxes reflect a mixture of sources including lithogenic material, hydrothermal inputs and authigenic phases. The fluxes of some commonly used paleo‐productivity proxies (TOC, biogenic opal, and Baxs) are not well‐correlated geographically with satellite‐based productivity estimates. Our new compilation of sedimentary fluxes provides detailed regional and global information, which will help refine the understanding of sediment preservation.
New Measurement of the Vertical Atmospheric Density Profile From Occultations of the Crab Nebula With X‐Ray Astronomy Satellites Suzaku and Hitomi
Authors: Katsuda Satoru , Fujiwara Hitoshi , Ishisaki Yoshitaka , Yoshitomo Maeda , Mori Koji , Motizuki Yuko , Sato Kosuke , Tashiro Makoto S. , Terada Yukikatsu 
Published: March 2021

AbstractWe present new measurements of the vertical density profile of the Earth's atmosphere at altitudes between 70 and 200 km, based on Earth occultations of the Crab Nebula observed with the X‐ray Imaging Spectrometer onboard Suzaku and the hard X‐ray Imager onboard Hitomi. X‐ray spectral variation due to the atmospheric absorption is used to derive tangential column densities of the absorbing species, that is, N and O including atoms and molecules, along the line of sight. The tangential column densities are then inverted to obtain the atmospheric number density. The data from 219 occultation scans at low latitudes in both hemispheres from September 15, 2005 to March 26, 2016 are analyzed to generate a single, highly averaged (in both space and time) vertical density profile. The density profile is in good agreement with the Naval‐Research‐Laboratory's‐Mass‐Spectrometer‐Incoherent‐Scatter‐Radar‐Extended (NRLMSISE‐00) model, except for the altitude range of 70–110 km, where the measured density is ∼50% smaller than the model. Such a deviation is consistent with the recent measurement with the SABER aboard the TIMED satellite (Cheng et al., 2020, https://doi.org/10.3390/atmos11040341). Given that the NRLMSISE‐00 model was constructed some time ago, the density decline could be due to the radiative cooling/contracting of the upper atmosphere as a result of greenhouse warming in the troposphere. However, we cannot rule out a possibility that the NRL model is simply imperfect in this region. We also present future prospects for the upcoming Japan‐US X‐ray astronomy satellite, X‐Ray Imaging and Spectroscopy Mission (XRISM), which will allow us to measure atmospheric composition with unprecedented spectral resolution of ΔE ∼ 5 eV in 0.3–12 keV.
Data‐Driven Simulation of Rapid Flux Enhancement of Energetic Electrons With an Upper‐Band Whistler Burst
Authors: Saito S. , Kurita S. , Miyoshi Y. , Kasahara S. , Yokota S. , Keika K. , Hori T. , Kasahara Y. , Matsuda S. , Shoji M. , Nakamura S. , Matsuoka A. , Imajo S. , Shinohara I. 
Published: March 2021

AbstractThe temporal variation of the energetic electron flux distribution caused by whistler mode chorus waves through the cyclotron resonant interaction provides crucial information on how electrons are accelerated in the Earth's inner magnetosphere. This study employs a data‐driven test‐particle simulation which demonstrates that the rapid change of energetic electron distribution observed by the Arase satellite cannot be simply explained by a quasi‐linear diffusion mechanism, but is essentially caused by nonlinear scattering: the phase trapping and the phase dislocation. In response to upper‐band whistler chorus bursts, multiple nonlinear interactions finally achieve an efficient flux enhancement of electrons on a time scale of the chorus burst. A quasi‐linear diffusion model tends to underestimate the flux enhancement of energetic electrons as compared with a model based on the realistic dynamic frequency spectrum of whistler waves. It is concluded that the nonlinear phase trapping plays an important role in the rapid flux enhancement of energetic electrons observed by Arase.
ULF Wave Driven Radial Diffusion During Geomagnetic Storms: A Statistical Analysis of Van Allen Probes Observations
Authors: Sandhu J. K. , Rae I. J. , Wygant J. R. , Breneman A. W. , Tian S. , Watt C. E. J. , Horne R. B. , Ozeke L. G. , Georgiou M. , Walach M.‐T. 
Published: March 2021

AbstractThe impact of radial diffusion in storm time radiation belt dynamics is well‐debated. In this study we quantify the changes and variability in radial diffusion coefficients during geomagnetic storms. A statistical analysis of Van Allen Probes data (2012–2019) is conducted to obtain measurements of the magnetic and electric power spectral densities for Ultra Low Frequency (ULF) waves, and corresponding radial diffusion coefficients. The results show global wave power enhancements occur during the storm main phase, and continue into the recovery phase. Local time asymmetries show sources of wave power are both external solar wind driving and internal sources from coupling with ring current ions and substorms. Wave power enhancements are also observed at low L values (L < 4). The accessibility of wave power to low L is attributed to a depression of the Alfvén continuum. The increased wave power drives enhancements in both the magnetic and electric field diffusion coefficients by more than an order of magnitude. Significant variability in diffusion coefficients is observed, with values ranging over several orders of magnitude. A comparison to the Kp parameterized empirical model of Ozeke et al. (2014) is conducted and indicates important differences during storm times. Although the electric field diffusion coefficient is relatively well described by the empirical model, the magnetic field diffusion coefficient is approximately ∼10 times larger than predicted. We discuss how differences could be attributed to data set limitations and assumptions. Alternative storm‐time radial diffusion coefficients are provided as a function of L* and storm phase.
High‐Energy Radiation From Natural Lightning Observed in Coincidence With a VHF Broadband Interferometer
Authors: Urbani M. , Montanyà J. , van der Velde O. A. , López J. A. , Arcanjo M. , Fontanes P. , Romero D. , Roncancio J. A. 
Published: March 2021

AbstractThis work presents the first simultaneous X‐ray measurements from natural lightning in coincidence with a very high frequency (VHF) broadband interferometer. During an observational campaign in north‐central Colombia, five intense X‐ray bursts were detected from negative stepped leaders and two X‐ray emissions from a dart leader. Thanks to the high angular and time resolution of the interferometer, it was possible to locate the origin of high‐energy radiation during the lightning leader propagation. We study the correlation with VHF pulses and the two‐dimensional speed of the leader channels. A strong temporal correspondence has been observed between the high‐energy emissions and the most intense VHF pulses, which suggests the runaway electrons as a shared mechanism. The observations show that an X‐ray burst can have multiple high‐energy sources belonging to different leader branches, that can be several hundreds of meters apart. Therefore, from a spatial point of view, not a unique origin has to be searched, but an extensive origin of the X‐ray burst should be considered. We hypothesize similar conclusions in particular for downward TGFs and maybe for TGFs in general.
U.S. Extreme Precipitation Weather Types Increased in Frequency During the 20th Century
Authors: Prein Andreas F. , Mearns Linda O. 
Published: March 2021

AbstractExtreme precipitation has increased in frequency and intensity across the Conterminous U.S. (CONUS). This trend is expected to continue under future climate change. The cause is a combination of thermodynamic (i.e., warmer temperatures increase the atmospheric moisture content) and dynamic changes (e.g., shifts in cyclone frequency and tracks). It is well‐established that thermodynamic changes will intensify extreme precipitation events, but the impacts of dynamic changes are more uncertain. Extreme events are, per definition, rare and occur in unusual weather situations that are distinctly different from regular day‐to‐day weather. We take advantage of this and identify extreme precipitation‐producing weather patterns (XWTs) for all major watersheds across the CONUS by using a novel algorithm. We show that a set of one to four XWTs per watershed are causing extreme precipitation accumulations. These XWTs can be detected based on their synoptic‐scale fingerprint and are associated with West Coast atmospheric rivers, troughing in the desert Southwest, cutoff lows and troughs in the central and northwestern plains, and tropical cyclones along the Gulf and Atlantic coast. The algorithm is flexible enough to provide reliable results for city to major watershed‐scales and can detect extremes that are unprecedented in the training record. Importantly, this approach allows us to assess long‐term trends in extreme precipitation dynamics and reveal that XWT frequencies increased significantly in most U.S. watersheds during the 20th century indicating that changes in the atmospheric dynamics played an important role in historic extreme precipitation increases.
Sedimentary Ancient DNA From the Subarctic North Pacific: How Sea Ice, Salinity, and Insolation Dynamics Have Shaped Diatom Composition and Richness Over the Past 20,000 Years
Authors: Zimmermann H. H. , Stoof‐Leichsenring K. R. , Kruse S. , Nürnberg D. , Tiedemann R. , Herzschuh U. 
Published: March 2021

AbstractWe traced diatom composition and diversity through time using diatom‐derived sedimentary ancient DNA (sedaDNA) from eastern continental slope sediments off Kamchatka (North Pacific) by applying a short, diatom‐specific marker on 63 samples in a DNA metabarcoding approach. The sequences were assigned to diatoms that are common in the area and characteristic of cold water. SedaDNA allowed us to observe shifts of potential lineages from species of the genus Chaetoceros that can be related to different climatic phases, suggesting that pre‐adapted ecotypes might have played a role in the long‐term success of species in areas of changing environmental conditions. These sedaDNA results complement our understanding of the long‐term history of diatom assemblages and their general relationship to environmental conditions of the past. Sea‐ice diatoms (Pauliella taeniata [Grunow] Round & Basson, Attheya septentrionalis [Østrup] R. M. Crawford and Nitzschia frigida [Grunow]) detected during the late glacial and Younger Dryas are in agreement with previous sea‐ice reconstructions. A positive correlation between pennate diatom richness and the sea‐ice proxy IP25 suggests that sea ice fosters pennate diatom richness, whereas a negative correlation with June insolation and temperature points to unfavorable conditions during the Holocene. A sharp increase in proportions of freshwater diatoms at ∼11.1 cal kyr BP implies the influence of terrestrial runoff and coincides with the loss of 42% of diatom sequence variants. We assume that reduced salinity at this time stabilized vertical stratification which limited the replenishment of nutrients in the euphotic zone.
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease
Authors: Zhao Miao , Wang Bingwei , Zhang Chenyu , Su Zhijie , Guo Bingbing , Zhao Yun , Zheng Ruimao 
Published: March 2021

AbstractThe pathogenesis of Parkinson’s disease (PD) remains unclear, and there is no disease-modifying agent for PD. Withaferin A (WA), a naturally occurring compound, has emerged as a neuroprotective agent. However, the mechanisms by which WA is neuroprotective in PD are unknown. Here we show that WA protected against loss of dopaminergic neurons, neuroinflammation, and motor deficits in MPTP-induced PD mouse models. Whole-genome deep sequencing analysis combined with Meta-analysis of human PD studies reveal that DJ1, Nrf2, and STING in substantia nigra pars compacta (SNc) are linked to anti-PD effect of WA. We found that WA activated DJ1 and Nrf2, and suppressed STING within SNc; and overexpression of STING in SNc dampened the effect of WA. Using genetically modified mice (DJ1-KO, Nrf2-KO, STINGgt/gt and STING-KO) and immunolabeling technique, we identified that WA targeted DJ1-Nrf2-STING pathway in dopaminergic neurons; and we demonstrate that STING might be an important factor in PD pathogenesis. In addition, WA alleviated accumulation of phosphorylated α-synuclein (p-α-syn) and insoluble α-syn within SNc in adeno-associated virus (AAV)-mediated human α-syn overexpression PD model. Our comparative analysis on whole-genome transcriptome profiles suggests that STING might be a key target of WA and amantadine in PD treatment. This study highlights a multifaceted role for WA in neuroprotection, and suggests that WA can be a potential candidate for treatment of PD.
Non-contrast dual-energy CT virtual ischemia maps accurately estimate ischemic core size in large-vessel occlusive stroke
Authors: Wolman Dylan N. , van Ommen Fasco , Tong Elizabeth , Kauw Frans , Dankbaar Jan Willem , Bennink Edwin , de Jong Hugo W. A. M. , Molvin Lior , Wintermark Max , Heit Jeremy J. 
Published: March 2021

AbstractDual-energy CT (DECT) material decomposition techniques may better detect edema within cerebral infarcts than conventional non-contrast CT (NCCT). This study compared if Virtual Ischemia Maps (VIM) derived from non-contrast DECT of patients with acute ischemic stroke due to large-vessel occlusion (AIS-LVO) are superior to NCCT for ischemic core estimation, compared against reference-standard DWI-MRI. Only patients whose baseline ischemic core was most likely to remain stable on follow-up MRI were included, defined as those with excellent post-thrombectomy revascularization or no perfusion mismatch. Twenty-four consecutive AIS-LVO patients with baseline non-contrast DECT, CT perfusion (CTP), and DWI-MRI were analyzed. The primary outcome measure was agreement between volumetric manually segmented VIM, NCCT, and automatically segmented CTP estimates of the ischemic core relative to manually segmented DWI volumes. Volume agreement was assessed using Bland–Altman plots and comparison of CT to DWI volume ratios. DWI volumes were better approximated by VIM than NCCT (VIM/DWI ratio 0.68 ± 0.35 vs. NCCT/DWI ratio 0.34 ± 0.35; P < 0.001) or CTP (CTP/DWI ratio 0.45 ± 0.67; P < 0.001), and VIM best correlated with DWI (rVIM = 0.90; rNCCT = 0.75; rCTP = 0.77; P < 0.001). Bland–Altman analyses indicated significantly greater agreement between DWI and VIM than NCCT core volumes (mean bias 0.60 [95%AI 0.39–0.82] vs. 0.20 [95%AI 0.11–0.30]). We conclude that DECT VIM estimates the ischemic core in AIS-LVO patients more accurately than NCCT.
RNA silencing suppressor-influenced performance of a virus vector delivering both guide RNA and Cas9 for CRISPR gene editing
Authors: Chiong Kelvin T. , Cody Will B. , Scholthof Herman B. 
Published: March 2021

AbstractWe report on further development of the agroinfiltratable Tobacco mosaic virus (TMV)-based overexpression (TRBO) vector to deliver CRISPR/Cas9 components into plants. First, production of a Cas9 (HcoCas9) protein from a binary plasmid increased when co-expressed in presence of suppressors of gene silencing, such as the TMV 126-kDa replicase or the Tomato bushy stunt virus P19 protein. Such suppressor-generated elevated levels of Cas9 expression translated to efficient gene editing mediated by TRBO-G-3′gGFP expressing GFP and also a single guide RNA targeting the mgfp5 gene in the Nicotiana benthamiana GFP-expressing line 16c. Furthermore, HcoCas9 encoding RNA, a large cargo insert of 4.2 kb, was expressed from TRBO-HcoCas9 to yield Cas9 protein again at higher levels upon co-expression with P19. Likewise, co-delivery of TRBO-HcoCas9 and TRBO-G-3′gGFP in the presence of P19 also resulted in elevated levels percentages of indels (insertions and deletions). These data also revealed an age-related phenomenon in plants whereby the RNA suppressor P19 had more of an effect in older plants. Lastly, we used a single TRBO vector to express both Cas9 and a sgRNA. Taken together, we suggest that viral RNA suppressors could be used for further optimization of single viral vector delivery of CRISPR gene editing parts.
Nonlocal single particle steering generated through single particle entanglement
Authors: Arévalo Aguilar L. M. 
Published: March 2021

AbstractIn 1927, at the Solvay conference, Einstein posed a thought experiment with the primary intention of showing the incompleteness of quantum mechanics; to prove it, he employed the instantaneous nonlocal effects caused by the collapse of the wavefunction of a single particle—the spooky action at a distance–, when a measurement is done. This historical event preceded the well-know Einstein–Podolsk–Rosen criticism over the incompleteness of quantum mechanics. Here, by using the Stern–Gerlach experiment, we demonstrate how the instantaneous nonlocal feature of the collapse of the wavefunction together with the single-particle entanglement can be used to produce the nonlocal effect of steering, i.e. the single-particle steering. In the steering process Bob gets a quantum state depending on which observable Alice decides to measure. To accomplish this, we fully exploit the spreading (over large distances) of the entangled wavefunction of the single-particle. In particular, we demonstrate that the nonlocality of the single-particle entangled state allows the particle to “know” about the kind of detector Alice is using to steer Bob’s state. Therefore, notwithstanding strong counterarguments, we prove that the single-particle entanglement gives rise to truly nonlocal effects at two faraway places. This opens the possibility of using the single-particle entanglement for implementing truly nonlocal task.
Effects of Lactobacillus salivarius isolated from feces of fast-growing pigs on intestinal microbiota and morphology of suckling piglets
Authors: Moturi Joseph , Kim Kwang Yeol , Hosseindoust Abdolreza , Lee Jun Hyung , Xuan Biao , Park Jongbin , Kim Eun Bae , Kim Jin Soo , Chae Byung Jo 
Published: March 2021

AbstractThe study determined the effects of Lactobacillus salivarius (LS) administered early in the life of suckling piglets on their growth performance, gut morphology, and gut microbiota. Thirty litters of 3-day-old crossbreed piglets were randomly assigned to one of the three treatments, and treatments were commenced on day 3 after birth. During the whole period of the experiment, the piglets were kept with their mothers and left to suckle ad libitum while being supplemented with a milk formula with or without the bacterial probiotic supplemented. The control group (CON) was not treated with probiotics, the HLS group was treated with LS144 (HLS) screened from feces of fast-growing pigs with high body mass index (BMI) while the NLS group was supplemented with LS160 (NLS) screened from feces obtained from pigs of normal BMI. At the weaning time, a higher abundance of Actinobacteria, Lentisphaerae, and Elusimicrobia phyla were observed in NLS piglets, whereas the abundance of Fibrobacteres phylum was significantly reduced in NLS and HLS piglets compared with the CON. A greater abundance of Lactobacillus was detected in the HLS treatment compared with the CON. The abundance of Bacteroides and Fibrobacter was higher in the CON piglets compared with the HLS and NLS piglets. Compared with the CON group, the oral administration of LS significantly increased the number of Lactobacillus and villus height in the duodenum, jejunum, and ileum. Moreover, the villus height of the duodenum was significantly improved in the HLS treatment compared with the NLS treatment. Based on the findings in the neonatal piglet model, we suggest that oral supplementation of LS, particularly LS isolated from high BMI pigs, could be beneficial by improving the intestinal villus height.
A spiking neural network (SNN) for detecting high frequency oscillations (HFOs) in the intraoperative ECoG
Authors: Burelo Karla , Sharifshazileh Mohammadali , Krayenbühl Niklaus , Ramantani Georgia , Indiveri Giacomo , Sarnthein Johannes 
Published: March 2021

AbstractTo achieve seizure freedom, epilepsy surgery requires the complete resection of the epileptogenic brain tissue. In intraoperative electrocorticography (ECoG) recordings, high frequency oscillations (HFOs) generated by epileptogenic tissue can be used to tailor the resection margin. However, automatic detection of HFOs in real-time remains an open challenge. Here we present a spiking neural network (SNN) for automatic HFO detection that is optimally suited for neuromorphic hardware implementation. We trained the SNN to detect HFO signals measured from intraoperative ECoG on-line, using an independently labeled dataset (58 min, 16 recordings). We targeted the detection of HFOs in the fast ripple frequency range (250-500 Hz) and compared the network results with the labeled HFO data. We endowed the SNN with a novel artifact rejection mechanism to suppress sharp transients and demonstrate its effectiveness on the ECoG dataset. The HFO rates (median 6.6 HFO/min in pre-resection recordings) detected by this SNN are comparable to those published in the dataset (Spearman’s $$\rho$$
ρ
= 0.81). The postsurgical seizure outcome was “predicted” with 100% (CI [63 100%]) accuracy for all 8 patients. These results provide a further step towards the construction of a real-time portable battery-operated HFO detection system that can be used during epilepsy surgery to guide the resection of the epileptogenic zone.