bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal Conductivity of BAs under Pressure
Authors: Hou Songrui , Sun Bo , Tian Fei , Cai Qingan , Xu Youming , Wang Shanmin , Peng Wanyue , Chen Xi , Ren Zhifeng , Li Chen , Wilson Richard 
Published: October 2021

Abstract
Boron arsenide (BAs) is an ultrahigh-thermal-conductivity material with special phonon-phonon scattering behaviors. At ambient pressure, the bunching of acoustic phonon branches in BAs is believed to result in a small phase space for three-phonon scattering. Density functional theory predicts that this acoustic phonon bunching effect is sensitive to pressure and leads to an unusual pressure dependence of thermal conductivity. To explore this physics, we measure the thermal conductivity of BAs from 0 to 25 GPa using time-domain thermoreflectance in a diamond anvil cell. We characterized two BAs samples with ambient thermal conductivities of 350 and 480 W m-1 K-1. Our experiments show that the thermal conductivity of both samples depends weakly on pressure from 0 to 25 GPa. We attribute the weak pressure dependence of the thermal conductivity of BAs to the weak pressure dependence of total phonon-phonon scattering rates. Our experimental results are consistent with DFT predictions that three-phonon scattering rates increase from 0 to 25 GPa, while four-phonon scattering rates decrease.
The Effect of NIV NAVA 0 on Ventilation in Premature Neonates
Authors: Protain Alison , Firestone Kimberly , Hussain Saima , Lubarsky Daniel , Stein Howard 
Published: October 2021

Abstract
Neonates with apnea of prematurity (AOP) deteriorate clinically because CPAP often provides inadequate support during apnea. NAVA provides proportional ventilator support from the electrical activity of the diaphragm. When NAVA level is 0 cmH20/mcV (NN0), patients receive minimal support when breathing and backup ventilation when apneic. This study addresses feasibility of NN0 and time spent in back up ventilation. This was a prospective, two center, observational study of preterm neonates on NN0 for AOP. Ventilator data were downloaded for 24 hours. Number of Clinically Significant Events (CSEs) and switches to back up were collected. Statistics were paired t-test. There were twenty-eight subjects with gestational age of 25 + 1.8 weeks; study age 28 ± 23 days. Number of events were 4±4.39 per 24 hours. Subjects were on NN0 approximately 90% each minute, back-up mode 2.5±1.1 times/minute with 10.6±7.2% in back-up. Conclusion: Preterm neonates on NAVA level 0 had few clinically significant events with minimal time in back up ventilation.
Factors Affecting Patient Satisfaction Related to Cost and Treatment Effectiveness in Rheumatoid Arthritis: Results From the Multicenter Observational Cohort Study, FRANK Registry
Authors: Fujiwara Toshifumi , Kondo Masakazu , Yamada Hisakata , Haraguchi Akihisa , Fujimura Kenjiro , Sakuraba Koji , Kamura Satoshi , Fukushi Jun-ichi , Miyahara Hisaaki , Inoue Yasushi , Tsuru Tomomi , Shuto Toshihide , Yoshizawa Seiji , Suematsu Eiichi , Miyamura Tomoya , Ayano Masahiro , Mitoma Hiroki , Arinobu Yojiro , Niiro Hiroaki , Ohishi Masanobu , Hirata Akie , Tokunaga Shoji , Takada Atsushi , Hara Daisuke , Tsushima Hidetoshi , Akasaki Yukio , Ikemura Satoshi , Sueishi Takuya , Toya Masakazu , Sakuragi Takahide , Tsutsui Tomoko , Kai Kazuhiro , Arisumi Shinkichi , Nakashima Yasuharu 
Published: October 2021

Abstract
Background. To further improve treatment for rheumatoid arthritis (RA), it is necessary to understand each RA patient satisfaction and to identify the factors affecting patient satisfaction. Despite of escalation of medical cost for RA, the affected factors of satisfaction for cost of treatment in RA patients has been little known.Methods. This is a multicenter observational study of RA patients at Fukuoka, Japan from the FRANK registry, and has been analyzed the initial registered data from March 2017 to August 2020. We collected data on demographic characteristics, clinical data, quality of life, which was assessed using the EuroQol 5-dimensional questionnaire (EQ5D), and patient satisfaction. Patient satisfaction was individually assessed by the four categories (i.e., cost, treatment efficacy, activities of daily living [ADL], and global treatment satisfaction). We analyzed the factors affected with each patient satisfaction, such as age, sex, EQ5D, disease duration, disease activity, and treatment.Results. This study included 2,235 RA outpatients (406 males, 1829 females). At the initial registration, “Very satisfied” and “Satisfied” were given for almost half of each satisfaction aspect (cost: 49%; effecacy: 72%; ADL: 58%; global treatment: 66%) in RA patients. To investigate the affected factors for each satisfaction, multivariate analysis has revealed that the use of b/tsDMARDs increased satisfaction of treatment effect (odds ratio [OR] 0.67) and ADL (OR 0.79), but decreased cost satisfaction (OR 2.24). Aging (50-64 years: OR 0.90, 65-74 years: 0.56, ≥75 years: 0.36), female (OR 0.80), and history of musculoskeletal surgery (OR 0.60) increased cost satisfaction. All aspects of patient satisfaction were elevated in those with lower disease activity and higher score of EQ5D. Conclusions. Patient satisfaction in terms of cost, treatment effect, ADL, and global treatment was generally better in this study, but still remained some patient with unsatisfaction. Cost of satisfaction was increased with aging and having the history of musculoskeletal surgery, and decreased in lower EQ5D score, and the use of b/tsDMARDs.
Patterns of contraceptive use among young Australian women with chronic disease: findings from a prospective cohort study
Authors: Harris Melissa , Egan Nicholas , Forder Peta M , Bateson Deborah , Sverdlov Aaron L , Murphy Vanessa E , Loxton Deborah 
Published: October 2021

Abstract
Background

Given chronic disease is increasing among young women and unintended pregnancies among these women are associated with poor maternal and fetal outcomes, these women would benefit from effective preconception care. However, there is a lack of understanding of how these women use or don’t use contraception to inform such interventions. This study examined patterns of contraceptive use among an Australian cohort of young women, with and without chronic disease, and investigated factors which influenced contraceptive use over time.
Methods

Using data from 15,244 young women from the Australian Longitudinal Study on Women’s Health (born 1989-95), latent transition analysis was performed to identify distinct contraceptive patterns among women who were at risk of an unintended pregnancy. Multinomial mixed-effect models were used to evaluate the relationship between contraceptive combinations and chronic disease.
Results

Differences in contraceptive use over time were found for women with cardiac disease, those with autoinflammatory diseases. Compared to women without chronic disease using the pill alone, women with cardiac disease had double the odds of using ‘other’ low efficacy contraception and condoms (OR=2.2, 95% CI: 1.34-3.59) and a modest increase in the odds of using the combined oral contraceptive pill and condoms (OR=1.39, 95% CI: 1.03-1.89). Women with autoinflammatory disease had increased odds of using LARC and condoms (OR=1.58, 95% CI: 1.04-2.41), using ‘other’ low efficacy contraception and condoms (OR=1.69, 95% CI: 1.11-2.57), and using combined oral contraceptive pill and condom use (OR=1.38, 95% CI: 1.09-1.75), compared to women without chronic disease using the pill. There was little evidence to suggest that contraceptive patterns differed for women with asthma or diabetes from women without chronic disease.
Conclusion

The findings identified a need for effective contraceptive counselling as part of routine chronic disease care and improved communication between healthcare providers and women with chronic disease to improve young women’s contraceptive knowledge and agency in contraceptive choice, particularly for those with cardiac or autoinflammatory conditions. This may be the key to reducing high-risk unintended pregnancies among this vulnerable population.
Renewable Energy in Morocco: Assessing risks to avoid a resource curse
Authors: Ahsan Aniq , Leonard Alycia , Charbonnier Flora , Hirmer Stephanie 
Published: October 2021

Abstract
In this policy briefing we investigate 14 potential risks which could cause renewable energy development in Morocco to provoke a resource curse. We identify the biggest risks to be economic dependence, technical dependence, and damage to flora and fauna. Policy objectives are identified to prevent or mitigate these risks. These are: careful negotiation of robust co-funding arrangements to safeguard Moroccan autonomy; the development of local renewable energy technology capabilities; and continuation and enhancement of environmental protection mandates.
Development of Brassica Napus L. Ogu-INRA CMS Restorers Using Recurrent Full-Sib Selection.
Authors: Lobos-Sujo Valeria , Duncan Robert W. 
Published: October 2021

Abstract
The Ogu-INRA CMS system in canola and rapeseed (Brassica napus L.) uses a cytological variant of the radish- (Raphanus sativus L.) derived Ogu CMS pollination control system introduced through interspecific introgression. The restorers (R-lines) contain an introgression that is associated with poor agronomic performance due to a large undesired segment of the radish chromosome that was introgressed along with the Rfo gene. The introgression contains pentatricopeptide (PPR) motif repeats that confer fertility restoration abilities to the R-lines. The objective of this research was to test the hypothesis that multiple cycles of intermating will result in R-lines with improved agronomic performance. A base population was developed by designing five R-line by R-line crosses. Twelve plants from each initial cross were grown and chain-crossed at random, without selection, other than the presence of the Rfo gene. Twelve flowers from each plant were crossed and the remainder of the plant was selfed. Three intermating crossing cycles (C0, C1 and C2) were completed and each was selfed three times for evaluation. Total pod number, seeds per pod, a visual pod rating, thousand seed weight and yield were evaluated. The visual pod rating showed a positive correlation with seeds per pod. Improvements for all traits were found at C0 and C1 when compared to the best parent. Individual families from two of the crosses showed a yield increase of over 78 % from the best parent. This suggests that improvements in yield components can be obtained from intermating R-lines.
Asporin Is Highly Expressed in CAFs of High Grade Serous Ovarian Cancinoma Patients and Predicts Poor Prognosis
Authors: Wang Lili , Zheng Xiangrong , Zhang Junhua , Zhang Wenwen , Huang Yan , Liu Yan , Jia Lin 
Published: October 2021

Abstract
Background: Tumor microenvironment is widely considered as a critical factor influencing prognosis of ovarian cancer patients. To further improve the unsatisfied clinical outcome of ovarian cancer patients, it is desperately needed to explore biomarkers with potential clinical value of ovarian cancer. Asporin (ASPN), as a member of the proteoglycan family in tumor microenvironment, has been proved to play a vital role in cancer progression by binding with CD44 receptor. However, there is still no report about the research of Asporin in ovarian cancer. The purpose of the present study was to explore the expression and prognostic significance of Asporin in high grade serous ovarian cancinoma(HGSOC). Methods: The expression level of Asporin and CD44 in 85 formalin fixed paraffin embedded (FFPE) samples of 85 HGSOC patients was detected by immunohistochemistry. The association between the expression of the two biomarkers and the clinicopathologic factors of HGSOC was assessed by χ² test. The survival analyses were performed by Kaplan-Meier.Results: Asporin was mainly expressed in CAFs of 85 HGSOC patients, while CD44 was mainly expressed on membrane of tumor cells. The positive rates of Asporin, CD44, and Asporin /CD44 co-expression were 43.53% (37/85), 34.12% (29/85) and 28.23% (24/85) in 85 HGSOC tissues, respectively. There were close associations between Asporin, CD44, Asporin/CD44 expression and CA125 level of blood, tumor differentiation, FIGO staging, chemoresistance of HGSOC patients. Further, univariate survival analysis showed that positive expression of Asporin and positive Asporin/CD44 co-expression of HGSOC indicated poor clinical outcomes, and multivariate survival analysis suggested that positive expression of Asporin and positive Asporin/CD44 co-expression were independent prognostic factors for disease–free survival (DFS) and overall survival (OS) of HGSOC patients, respectively.Conclusion: Asporin was mainly expressed in CAFs of HGSOC patients. High expression of Asporin may identify a subgroup of HGSOC patients with more chemoresistance clinicopathological features and may be a potential prognostic predictor and therapeutic target for HGSOC patients.
In Vitro Evaluation of a Hypobromous Acid Hygiene Stabilized Solution in the Reduction of Bacterial Load Associated to Blepharitis Conditions
Authors: Silvani Ludovica , Bedei Andrea Campus , Castellini Laura , De grazia Giulia , Remiddi Stefano 
Published: October 2021

Abstract
Blepharitis is a chronic inflammation of the periocular skin area and it is characterized by eye itching, burning, dryness and irritation, with progression to chronic dry eye syndrome, where the eyelids margins of blepharitis patients are frequently colonized by bacteria.The aim of the present study was to investigate the in vitro bactericidal activity (BA) of a stabilized active bromine solution (MDI-102) at neutral pH for the potential use in the treatment and prevention of blepharitis.The time kill assays have been conducted both in clean and in dirty conditions (by using bovine albumin solution as the interfering substance) at different ranges of concentration.The results show the topical solution to be capable of inactivating, in less than 0.5 minutes, more than 99.9% of several bacterial species involved in the clinical manifestations of blepharitis: Enterococcus hirae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Serratia marcescens. Dirty condition tests confirm the results shown without albumin (clean conditions).This study demonstrates that MDI-102 active bromine solution can markedly reduce (in vitro) the bacterial activity, responsible of clinical manifestation of blepharitis. Thus, MDI-102 can be considered a promising tool for the periocular area and eyelids cleaning for blepharitis patients.The use of this formulation may contribute in the long-term prevention and hygienic treatment of blepharitis condition. Furthermore, MDI-102 can be considered as an alternative to reduce the use and the abuse of topical antibiotics in the daily practice, which may contribute to the increase of resistance to the antibiotics in the clinical setting.
Evaluation of land suitability for Oilseeds crops (Sesame and Groundnut) using GIS and Multi-criteria evaluation: A case study of Diga District, East Wollega Zone, Western Ethiopia
Authors: Merga Biratu Bobo , Moisa Mitiku Badasa , Gemeda Dessalegn Obsi 
Published: October 2021

Abstract
Sesame and groundnut crops are the major oilseeds crops produced for exports and local consumptions in the Ethiopia. This study attempted to evaluate land suitability for oilseeds crops using Geographic Information Systems (GIS) and Multi-criteria evaluation (MCE), in the case of Diga district, East Wollega zone, Western Ethiopia. By integrating GIS and MCE techniques land suitability maps for sesame and groundnut were produced. Climate data (Temperature and rainfall), topography data (Slope), soil data (Soil texture, soil depth and soil drainage), infrastructure data (Road and market) were used in this study. The result of the study revealed that, about 252.1ha (0.4%) and 113.1ha (0.2%) were highly suitable for sesame and groundnut crops, respectively. Our results show that most parts of the study area were moderately suitable for sesame and groundnut production. Specially, the central and western parts of the study area are highly suitable and moderately suitable for sesame production. Findings of this study can support the farming communities and decision makers through providing highly productive areas for sesame and groundnut production.
Vertical Injection and Wideband Grating Coupler Based on Asymmetric Grating Trenches
Authors: Asaduzzaman Md , Chapman Robert J. , Johnson Brett C. , Peruzzo Alberto 
Published: October 2021

Abstract
A Silicon-on-insulator (SOI) perfectly vertical fibre-to-chip grating coupler is proposed and designed based on engineered subwavelength structures. The high directionality of the coupler is achieved by implementing step gratings to realize asymmetric diffraction and by applying effective index variation with auxiliary ultra-subwavelength gratings. The proposed structure is numerically analysed by using two-dimensional Finite Difference Time Domain (2D FDTD) method and achieves 76% (-1.19 dB) coupling efficiency and 39 nm 1-dB bandwidth.
Examination of main lymph node (No.253) metastasis in left colorectal cancer: A retrospective analysis of a single-institution cohort
Authors: Yoshida Takefumi , Fujita Fumihiko , Shida Dai , Koushi Kenichi , Fujiyoshi Kenji , Sudou Tomoya , Nagasu Sachiko , Ogata Suguru , Noguchi Takashi , Fukuda Junya , Koga Fumiki , Kikuchi Maako , Akagi Yoshito 
Published: October 2021

Abstract
Background.
The extent of lymph node dissection in advanced colorectal cancer varies according to regional guidelines. D3 lymphadenectomy is routinely performed in Japan but is associated with several risk factors. Metastases of the main lymph nodes (No.253 lymph nodes), which are located at the root of the inferior mesenteric artery, are rare in left-sided colorectal cancer. Tumor depth (T4) is an identifier of No.253 lymph node metastasis (LNM) risk, but other risk factors associated with No.253 LNM are unclear. This study was undertaken to investigate the frequency of No.253 LNM and to identify other clinicopathological risk factors associated with No.253 LNM in left-sided colorectal cancer. In this study, we aimed to evaluate the clinical benefit of routine D3 lymphadenectomy in surgically treated advanced colorectal cancer.
Methods.
A retrospective database of patients with colorectal cancer who underwent D3 dissection and R0 resection at Kurume University Hospital from 1978 to 2017 was constructed and used to search for the frequency and risk factors of No.253 LNM to investigate long-term prognosis. Clinicopathological factors associated with No.253 LNM, including age, sex, tumor location, T stage, tumor diameter, carcinoembryonic antigen levels, and various dissected lymph nodes, were analyzed.
Results.
Among 1,614 consecutive patients, No.253 LNM was observed in 23 cases (1.4%). The presence of three or more regional LNMs was an independent risk factor for No.253 LNM (odds ratio: 26.8). The 5-year overall survival rate was 49.1% in the No.253 LNM-positive group and 78.4% in the No.253 LNM-negative group (p=0.002).
Conclusion.
In left-sided colorectal cancer, No.253 LNM was a poor prognosis factor, and three or more regional LNMs were a risk factor for No.253 LNM. The No.253 LNM-positive group had a poor prognosis, but there are cases of long-term survival, with a 5-year survival rate of 49%. D3 lymphadenectomy is suitable when three or more metastatic LNs are identified prior to surgery.
Hydrogen-Rich Medium Ameliorates Lipopolysaccharides-Induced Mitochondrial Fission and Dysfunction in Human Umbilical Vein Endothelial Cells (Huvecs) via Up-Regulating HO-1 Expression
Authors: Xie Keliang , Mao Xing , Lian Naqi , Wang Yanyan , Wang Yuzun , Chen Hongguang , Zhu Ruqing , Yu Yonghao , Wang Guolin 
Published: October 2021

Abstract
Background

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It has been showed that the change of mitochondrial dynamics has been proved to be one of the main causes of death in patients with severe sepsis. And hydrogen has been proved to exert its protective effects against sepsis via heme oxygenase-1 (HO-1). This study was designed to demonstrate that whether the benefit effects of hydrogen can maintain the dynamic process of mitochondrial fusion/fission to mitigate human umbilical vein endothelial cells (HUVECs) injury exposed to endotoxin through HO-1.
Methods

HUVECs cells cultured with medium which contained Lipopolysaccharides (LPS), Saline, hydrogen, Mdivi-1 (a dynamin-related protein 1 [Drp1] inhibitor) or zinc protoporphyrin Ⅸ (Znpp) (a HO-1 inhibitor) were also used in the research. Cell death and apoptosis were assessed using FITC annexin V and PI. Mitochondria were stained with Mitotracker orange and observed by confocal microscope. Oxygen consumption rate was assessed by seahorse xf24 extracellular analyzer. Mitochondrial membrane potential monitored by JC-1 dye. The expressions of Drp1 and HO-1 were tested by Western blot. The co-localization of Drp1 and mitochondria was determined by immunofluorescence.
Results

LPS caused a decrease in ATP content, mitochondrial membrane potential, and maximal respiration rate. At the same time, increased expression of Drp1 were observed in LPS-stimulated HUVECs, concomitantly with excessive mitochondrial fission. We found that hydrogen-rich medium can increase ATP content, mitochondrial membrane potential and maximal respiration rate, and decrease the expression of Drp1 in LPS-treated HUVECs. Meanwhile, hydrogen can ameliorate excessive mitochondrial fission caused by LPS. Furthermore, hydrogen-rich medium had a similar effect to Mdivi-1, a mitochondrial fission blocker. Both of them rescued the up-regulation of Drp1 and mitochondrial fission induced by LPS, then normalized mitochondrial shape after LPS stimulation. But after Znpp pretreatment, HO-1 expression was inhibited and the protective effects of hydrogen were abrogated.
Conclusions

Hydrogen-rich medium can alleviate the LPS-induced mitochondrial fusion/fission and dysfunction in HUVECs via HO-1 up-regulation.
Various responses of pine marten morphology and demography to temporal climate changes and primary productivity
Authors: Wereszczuk Anna , Fedotova Anastasia , Marciszak Adrian , Popiołek Marcin , Zharova Arsenia , Zalewski Andrzej 
Published: October 2021

Abstract
Climate and environmental changes affect species’ morphology and ecology; however, the response of a species to changes in abiotic and biotic factors is not always consistent. Here, we tested how the structural body size of the pine marten and its population sex ratio changed over time and alongside climate change. We analysed temporal changes in morphological traits using 11 measurements of pine marten skulls collected between 1903 to 2020, linking them with climatic and primary production variations. We assessed demographic changes by calculating temporal sex ratio changes over 61 years. Skull size, as a proxy of body size, increased in response to warmer and less snowy winters, with a three-year time-lag. However, changes in primary productivity rapidly shaped postorbital constriction regardless of body size changes and without time-lags, potentially demonstrating increased diet diversity in pine marten. According to climate change, the population sex ratio has skewed towards males over time. Our results suggest that climate conditions and primary production affect skull structural size, highlighting the potential various responses of pine marten morphology and ecology in relation to climate change. Recently changing population demographics, as a consequence of these processes, may constitute a threat to marten populations.