bluuebunny/crossref_metadata_2025_split huggingface dataset:
The occupational impact of bowel cancer: Survivors' voices and advancing the role of occupational therapy assessment and intervention
Authors: Martin Elizabeth , Hocking Clare , Sandham Margaret 
Published: October 2021

AbstractIntroductionThe aim of this study was to investigate the occupational impact (i.e., how engagement in occupation is affected) of having had bowel cancer and the role of occupational therapy with bowel cancer survivors and their significant others.MethodsTwo rounds of semi‐structured interviews were carried out with individuals who had completed treatment for bowel cancer, with interviews designed to gain insight into their occupational experiences post treatment. Thematic analysis was utilised to construct themes and patterns founded on the perceptions of participants. Analysis involved concurrent data collection and analysis, constant comparative analysis, and iterative analysis.FindingsEighteen participants were interviewed, with occupational impact evident across multiple aspects of everyday life. Four themes were identified: Changes in eating habits, changes in toileting habits, changes in relationships, and rethinking occupational choices.ConclusionFindings of the occupational impact of having had bowel cancer reveal a possible role for occupational therapists with people affected by bowel cancer. Occupation focused assessments and self‐management programmes are identified as a possible means of meeting the needs of this population, making use of the experiences of peers to provide a credible, relatable voice.
Do Learning Benefits Accrue Equally Over Successive Fundraising Attempts? Strategic Change and the Moderating Role of Experience
Authors: Sewaid Ahmed , Garcia‐Cestona Miguel , Silaghi Florina 
Published: October 2021

AbstractIn the management literature, the role of learning from experience and its effect on performance has been highlighted. However, little is known about the effects of strategic change on performance due to aspects pertaining to the mobility of learning. Building on different learning theories, we theorize about the effect of strategic change on performance when: (i) strategic change does not require the mobilizing of resources; (ii) strategic change does not involve exposure to a new set of stakeholders; and (iii) time commitment to previous strategies is low. We confront our contentions with data on serial campaign launchers in crowdfunding. The data indicates that changing industry adversely affects fundraising performance due to the specificity of a portion of the accrued learning. This adverse effect is mitigated by venture launching experience and exacerbated following failure. Implications for practitioners and scholars are discussed.
Development of green skills module for meat processing technology study
Authors: Handayani Mustika Nuramalia , Kamis Arasinah , Ali Mohammad , Wahyudin Dinn , Mukhidin Mukhidin 
Published: October 2021

AbstractGreen skills need to be developed in vocational education for sustainable future. However, the vocational high school curriculum of agricultural food processing technology in Indonesia does not explicitly state the development of green skills. Teaching materials, such as module are needed to develop vocational students’ green skills. This study aimed to develop green skills module for meat processing technology at vocational high schools. Development of this module used the analysis, design, development, implementation, and evaluation (ADDIE) model. The contents for a green skills module were developed based on a need analysis for the elements of green skills that must be developed in vocational high schools, curriculum and a literature review analysis related to sustainability in meat processing technology. The module was designed using a scientific approach to strengthen active student learning as per the 2013 curriculum policy for vocational high schools in Indonesia. The developed module was sent to the four selected experts for validating. It gained score of 88.56% in material aspect about meat processing technology by the material experts and 89.18% in media aspects by the media experts. These scores mean that the module was categorized as very feasible. Based on the pre‐test and post‐test of students’ green skills with this module, the calculation of n‐gain test was 0.4 which means moderate category. The findings of this study imply that the module can be used in learning to improve student's green skills. This study may be adapted for the development of other subject modules in vocational schools.
Employee voice, psychologisation and human resource management (HRM)
Authors: Barry Michael , Wilkinson Adrian 
Published: October 2021

AbstractThe ‘psychologisation’ of the human resource management (HRM) and industrial relations (IR) has been a major topic of conversation in management journals, not least in HRMJ (Farndale et al., 2020). We contribute to this debate by focussing on employee voice as an important topic of scholarship, and by explaining how this topic has been psychologised over time. First, we review organisational behaviour (OB) voice literature from the 1980s onwards to show how OB voice has itself shifted, and narrowed, over time, making OB voice a more static phenomenon, and one that marginalises other perspectives and stakeholders. In our review, we distinguish between what we call the ‘old’ and ‘new’ OB voice scholarship, the latter occurring from the mid‐1990s onwards. We then review all voice publications across four major HR journals from 2000 onwards, to show how OB's psychologised conception of voice has influenced HR voice, and the implications of this for HRM.
Genome‐wide single nucleotide polymorphism array and whole‐genome sequencing reveal the inbreeding progression of Banna minipig inbred line
Authors: Huo J. L. , Zhang L. Q. , Zhang X. , Wu X. W. , Ye X. H. , Sun Y. H. , Cheng W. M. , Yang K. , Pan W. R. , Zeng Y. Z. 
Published: October 2021

SummaryInbred pigs are promising animal models for biomedical research and xenotransplantation. Established in 1980, the Banna minipig inbred (BMI) line originated from a sow and its own male offspring. It was selected from a small backcountry minority Lahu village, where records show that no other pig breed has ever been introduced. During the inbreeding process, we perfomed extreme inbreeding over 23 consecutive generations using full‐sibling or parent–offspring mating. In order to investigate the inbreeding effects in BMI pigs across generations over the past 40 years, in this study we conducted a genome‐wide SNP genotyping of the last 10 generations, representing generations 14–23. In total, we genotyped 57,746 SNPs, corresponding to an average decrease in heterozygosity rate of 0.0078 per generation. Furthermore, we were only able to identify 18,216 polymorphic loci with a MAF larger than 0.05, which is substantially lower than the values in previous reports on other pig breeds. In addition, we sequenced the genome of the first pig in the twenty‐third generation (inbreeding coefficient 99.28%) to an average coverage of 12.4× to evaluate at the genome level the impact of advanced inbreeding. ROH analysis indicates that BMI pigs have longer ROHs than Wuzhishan and Duroc pigs. Those long ROH regions in BMI pigs are enriched for distinct functions compared with the highly polymorphic regions. Our study reveals a genome‐wide allele diversity loss during the progress of inbreeding in BMI pigs and characterizes ROH and polymorphic regions as a result of inbreeding. Overall, our results indicate the successful establishment of the BMI line, which paves the way for further in‐depth studies.
Economic value of tropical inland freshwater shallow lakes: Lesson from Lake Malombe, Malawi
Authors: Makwinja Rodgers , Mengistou Seyoum , Kaunda Emmanuel , Alamirew Tena 
Published: October 2021

AbstractFreshwater lakes provide critical ecosystem services (ESs) to local and global communities. However, many of these lakes are under serious threat from degradation, over‐exploitation and pollution instigated by unsustainable use and a lack of practical management approaches. Under such conditions, it is critical to quantify the ESs of these lakes and uncover factors affecting local population participation in the conservation. The current study aims to fill this research gap by employing data collection techniques such as household surveys, focus group discussion, field observation, key informant interviews, consultative meetings and a meta‐analytical approach. Lake Malombe has been selected to depict the African freshwater ecosystems’ scenarios. The findings show that 97.74% of the households depend on the lake ESs. The ESs contribute US$124.36 million/year—about 1.97% of Malawi’s GDP and US$1943.08/household/year. Factors such as literacy level, household level of income, age of household head, gender of household and household experiences food shortages significantly (p < 0.05) influenced participation level. The study recommends integrating the economic incentive model into the local policy framework. For example, promoting ecotourism, agroforestry and integrated fish farming can provide economic incentives, reduce direct dependency and increase local participation in conservation.
Starting from scratch: Developing and sustaining a rural research team lessons from a nutrition and dietetics case study
Authors: Brown Leanne J. , Urquhart Lisa , Squires Kelly , Crowley Elesa , Heaney Susan , Kocanda Lucy , Schumacher Tracy 
Published: October 2021

AbstractObjectiveTo describe the development of and key factors for sustaining a rural‐based research team focussed on nutrition and dietetics.DesignA longitudinal embedded case study approach with data sourced from publicly available records and observations. Case study sub‐units were developed into 3 phases with analysis using theoretical propositions and pattern matching. Quantitative data were descriptively analysed.SettingUniversity of Newcastle Department of Rural Health across 4 rural sites.ParticipantsPublicly available data sources from existing team members.Main outcome measuresStaffing levels, research supervision, internal and external grant outcomes and peer‐reviewed journal publications.ResultAcademic staffing has increased by 4 full‐time equivalent positions over 18 years, with 6 current higher‐degree research students. Key factors identified in the development of a discipline‐specific research workforce included staff higher degree by research completions, longevity of staff in research‐active roles, immersive rural placements with a research component and collaborations with nationally competitive researchers. Rural pilot research projects, community connections, understanding of the local context and research networks were fundamental to establishing a viable team.ConclusionSystematically investing in research that is embedded in local communities will ensure sustainability and relevance, capacity building of existing staff and an ability to problem solve at the local level. Sustained and focussed investment is needed if the current rural research workforce is to develop towards a capacity that meets current demand.
Open versus laparoscopic lateral lymph node dissection for mid‐ and low‐ rectal cancer: a propensity score matching study
Authors: Zhang Yang , Yang Xuyang , Wang Di , Zhuang Zixuan , Wei Mingtian , Meng Wenjian , Deng Xiangbing , Wang Ziqiang 
Published: October 2021

AbstractBackgroundThis study aimed to evaluate the perioperative, pathological and oncological outcomes of open versus laparoscopic total mesorectal excision (TME) plus lateral lymph node dissection (LLND) for mid‐ and low‐ rectal cancer using propensity score matching.MethodsBetween September 2009 and December 2018, consecutive patients who underwent open or laparoscopic TME plus LLND were collected. Based on the propensity score matching analysis, laparoscopic TME plus LLND was compared with open TME plus LLND for the perioperative, pathological, and oncological outcomes.ResultsA total of 77 patients were collected. There were 13 patients who underwent open TME plus LLND (open group) and 64 patients who underwent laparoscopic TME plus LLND (laparoscopic group). After propensity score matching, 13 patients in the open group were matched to 39 patients in the laparoscopic group (1:3). The laparoscopic group had a significantly shorter length of incision (5 cm vs. 20 cm, p < 0.01), less intraoperative blood loss (80 mL vs. 100 mL, p = 0.02), and shorter time to postoperative liquid diet (72 h vs. 96 h, p = 0.05). There were no significant differences in both early and late postoperative complications. The 3‐year overall survival was 85.9% in the laparoscopic group and 76.9% in the open group (p = 0.75), respectively. The 3‐year disease‐free survival was 70.6% in the laparoscopic group and 74.1% in the open group (p = 0.83), respectively.ConclusionLaparoscopic LLND had comparable oncological outcomes to open LLND. Moreover, laparoscopic LLND had postoperative recovery advantages over open LLND.
Retinal venular oxygen saturation is associated with non‐proliferative diabetic retinopathy in young patients with type 1 diabetes
Authors: Veiby Nina C.B.B. , Simeunovic Aida , Heier Martin , Brunborg Cathrine , Saddique Naila , Moe Morten C. , Dahl‐Jørgensen Knut , Petrovski Goran , Margeirsdottir Hanna D. 
Published: October 2021

AbstractPurposeTo determine the contribution of retinal vessel density (VD), central retinal vessel diameter and retinal oxygen (O2) saturation independently of other known risk factors in the development of non‐proliferative diabetic retinopathy (NPDR).MethodsMacular optical coherence tomography angiography (OCTA), central retinal artery/vein equivalent diameter (CRAE/CRVE) measurements and retinal oximetry were performed in a cross‐sectional study of 166 eyes from 166 individuals with type 1 diabetes (T1D) aged 14–30 years. Multiple logistic regression analysis was used to investigate whether O2 saturation, retinal vessel diameters and vessel density in the deep capillary plexus (VD‐DCP) were associated with NPDR, when adjusting for known risk factors. The individuals were allocated to one group without and one group with NPDR.ResultsMultiple logistic regression analysis showed that age (OR = 1.25, 95% CI: 1.04–1.49) and AV‐difference in O2 saturation (OR = 0.85, 95% CI 0.77–0.93) were significantly associated with NPDR.ConclusionOur findings suggest that age and lower AV‐O2 saturation difference contribute to explaining the grade of NPDR independently of other well‐known risk factors. Reduced delivery of O2 to the retinal tissue is associated with the development of NPDR in young patients with T1D and should be given appropriate weight in the risk stratification at early stages of the disease.
Response of eosinophilic oesophagitis to proton pump inhibitors is associated with impedance‐pH parameters implying anti‐reflux mechanism of action
Authors: Frazzoni Marzio , Frazzoni Leonardo , De Bortoli Nicola , Russo Salvatore , Tolone Salvatore , Arsiè Elena , Conigliaro Rita , Penagini Roberto , Savarino Edoardo 
Published: October 2021

SummaryBackgroundProton pump inhibitors (PPIs) are effective therapies for eosinophilic oesophagitis (EoE), but the mechanism of action is uncertain. At on‐PPI impedance‐pH monitoring, improvement in oesophageal chemical clearance assessed with post‐reflux swallow‐induced peristaltic wave (PSPW) index characterises PPI‐responsive EoE and reflux disease. Off‐PPI, higher efficacy of the oesophago‐salivary reflex as measured with PSPW‐associated pH increments characterises PPI‐responsive reflux disease and could typify PPI‐responsive EoE as well.AimTo establish whether PPI responsiveness in EoE is associated with higher efficacy of the oesophago‐salivary reflex.MethodsProspective multicentre study in EoE patients investigated with impedance‐pH monitoring before starting PPI. Impedance‐pH parameters in PPI‐responsive and PPI‐refractory cases were compared. PPI response was defined histologically.ResultsConsiderable PSPW‐associated pH increments (median 1.4 units) were found in 80 EoE patients, with significantly higher values in 48 PPI‐responsive than in 32 PPI‐refractory cases (1.8 vs 1.0, P = 0.02). Mucosal integrity, as measured with mean nocturnal baseline impedance was more severely impaired in the distal oesophagus in PPI‐responsive cases, the gradient between mid and distal oesophagus being significantly higher (546 vs 137 Ω, P = 0.0002). PSPW‐associated pH increments and the baseline impedance gradient between mid and distal oesophagus were independently associated with histological response at multivariable logistic regression; at receiver operating characteristic analysis, the area under the curve of PPI response calculated by combined assessment was 0.88.ConclusionHigher efficacy of oesophago‐salivary reflex and more severe mucosal damage in the distal oesophagus are associated with EoE response to PPIs, implying an anti‐reflux mechanism of action as most likely.
A mediation meta‐analysis of the role of maternal responsivity in the association between socioeconomic risk and children’s language
Authors: Borairi Sahar , Fearon Pasco , Madigan Sheri , Plamondon Andre , Jenkins Jennifer 
Published: October 2021

AbstractThis meta‐analysis tested maternal responsivity as a mediator of the association between socioeconomic risk and children's preschool language abilities. The search included studies up to 2017 and meta‐analytic structural equation modeling, allowed us to examine the magnitude of the indirect effect across 17 studies (k = 19). The meta‐analysis included 6433 predominantly White, English speaking children (Mage = 36 months; 50% female) from Western, industrialized countries. All paths in the model were statistically significant, notably, the indirect effect was significant (b = −.052), showing that maternal responsivity may be a proximal intervening variable between socioeconomic risk and children's language development. Moderator analyses found that the indirect effect was stronger for sensitive parenting than warmth and when parenting was assessed in the family home.
Growth, puberty and testicular function in boys born small for gestational age with a nonspecific disorder of sex development
Authors: Tack Lloyd J. W. , van der Straaten Saskia , Riedl Stefan , Springer Alexander , Holterhus Paul‐Martin , Hornig Nadine C. , Kolesinska Zofia , Niedziela Marek , Baronio Federico , Balsamo Antonio , Hannema Sabine E. , Nordenström Anna , Poyrazoglu Sukran , Darendeliler Fatma F. , Grinspon Romina , Rey Rodolfo , Aljuraibah Fahad , Bryce Jillian , Ahmed Faisal , Tadokoro‐Cuccaro Rieko , Hughes Ieuan , Guaragna‐Filho Guilherme , Maciel‐Guerra Andrea T. , Guerra‐Junior Gil , Cools Martine 
Published: October 2021

AbstractObjectiveBeing born small for gestational age (SGA) is frequently associated with unexplained disorders of sex development (nonspecific DSD) in boys. Little is known about their future growth, puberty and testicular function. Our objective is to determine the long‐term endocrine outcome of boys born SGA who have a nonspecific DSD.DesignBoys with a nonspecific DSD born SGA and appropriate for GA (AGA) were retrieved through the International Disorders of Sex Development registry and retrospective data collected, based on a spreadsheet containing 102 items.Patients and MeasurementsIn total, 179 boys were included, of which 115 were born SGA and 64 were born AGA. Their growth and pubertal development were compared. Serum LH, FSH, testosterone, AMH and inhibin B levels in infancy and puberty were analysed to assess testicular function.ResultsAt 2 years of age, 30% of SGA boys had incomplete or absent catch‐up growth. Boys born SGA also had higher LH during minipuberty and lower testosterone in stimulation tests (p = 0.037 and 0.040, respectively), as compared to boys born AGA. No differences were observed in timing or course of puberty or end‐pubertal hormone levels.ConclusionsAlmost one out of three SGA boys with a nonspecific DSD experiences insufficient catch‐up growth. In addition, our data suggest dysfunction of infantile Leydig cells or altered regulation of the hypothalamic–pituitary–gonadal axis in SGA boys during childhood. Sex steroid production during puberty seems unaffected.
The broader phenotypic spectrum of congenital caudal abnormalities associated with mutations in the caudal type homeobox 2 gene
Authors: Stevens Servi J. C. , Stumpel Constance T. R. M. , Diderich Karin E. M. , van Slegtenhorst Marjon A. , Abbott Mary‐Alice , Manning Courtney , Balciuniene Jorune , Pyle Louise C. , Leonard Jacqueline , Murrell Jill R. , van de Putte Romy , van Rooij Iris A. L. M. , Hoischen Alexander , Lasko Paul , Brunner Han G. 
Published: October 2021

AbstractThe caudal type homeobox 2 (CDX2) gene encodes a developmental regulator involved in caudal body patterning. Only three pathogenic variants in human CDX2 have been described, in patients with persistent cloaca, sirenomelia and/or renal and anogenital malformations. We identified five patients with de novo or inherited pathogenic variants in CDX2 with clinical phenotypes that partially overlap with previous cases, that is, imperforate anus and renal, urogenital and limb abnormalities. However, additional clinical features were seen including vertebral agenesis and we describe considerable phenotypic variability, even in unrelated patients with the same recurrent p.(Arg237His) variant. We propose CDX2 variants as rare genetic cause for a multiple congenital anomaly syndrome that can include features of caudal regression syndrome and VACTERL. A causative role is further substantiated by the relationship between CDX2 and other proteins encoded by genes that were previously linked to caudal abnormalities in humans, for example, TBXT (sacral agenesis and other vertebral segmentation defects) and CDX1 (anorectal malformations). Our findings confirm the essential role of CDX2 in caudal morphogenesis and formation of cloacal derivatives in humans, which to date has only been well characterized in animals.
Leveraging shark‐fin consumer preferences to deliver sustainable fisheries
Authors: Zhou Xuehong , Booth Hollie , Li Mingzhe , Song Zhifan , MacMillan Douglas C. , Zhang Wei , Wang Qiang , Veríssimo Diogo 
Published: October 2021

AbstractAt least one third of sharks and their cartilaginous relatives (Class Chondrichthyes) meet the IUCN Red List Criteria for being threatened with extinction. Overfishing is the primary threat, with less than 4% of the world's shark catches managed for sustainability. The high‐value shark‐fin trade has gained the greatest attention as a conservation issue, yet there has been little research on shark‐fin consumer preferences, and how these might be leveraged to deliver sustainability goals. We used an online discrete choice experiment to explore preferences for price, quality, rarity, and finning among 2914 shark‐fin soup consumers in China. Overall, consumers prefer higher priced and rare shark‐fins, obtained without finning, yet we found three distinct groups with substantial heterogeneity between them. Our results provide evidence for the conspicuous consumption nature of shark‐fin use, but also suggest these preferences could be leveraged to incentivize responsible shark fishing. In addition, messaging for future unsustainable demand reduction should focus on shark‐finning and animal welfare as opposed species rarity and extinction.