bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of influenza and pneumococcal vaccination in the elderly on health service utilisation and costs: a claims data-based cohort study
Authors: Storch Josephine , Fleischmann-Struzek Carolin , Rose Norman , Lehmann Thomas , Mikolajetz Anna , Maddela Srikanth , Pletz Mathias W. , Forstner Christina , Wichmann Ole , Neufeind Julia , Vogel Monique , Reinhart Konrad , Vollmar Horst Christian , Freytag Antje ,   the Vaccination 60+ Study Group
Published: July 2021

Abstract
Background
To date, cost-effectiveness of influenza and pneumococcal vaccinations was assumed in several health economic modelling studies, but confirmation by real-world data is sparse. The aim of this study is to assess the effects on health care utilisation and costs in the elderly using real-world data on both, outpatient and inpatient care.

Methods
Retrospective community-based cohort study with 138,877 individuals aged ≥ 60 years, insured in a large health insurance fund in Thuringia (Germany). We assessed health care utilisation and costs due to influenza- or pneumococcal-associated diseases, respiratory infections, and sepsis in 2015 and 2016. Individuals were classified into four groups according to their vaccination status from 2008 to 2016 (none, both, or either only influenza or pneumococcal vaccination). Inverse probability weighting based on 236 pre-treatment covariates was used to adjust for potential indication and healthy vaccinee bias.

Results
Influenza vaccination appeared as cost-saving in 2016, with lower disease-related health care costs of − €178.87 [95% CI − €240.03;− €117.17] per individual (2015: − €50.02 [95% CI − €115.48;€15.44]). Cost-savings mainly resulted from hospital inpatient care, whereas higher costs occurred for outpatient care. Overall cost savings of pneumococcal vaccination were not statistically significant in both years, but disease-related outpatient care costs were lower in pneumococci-vaccinated individuals in 2015 [− €9.43; 95% CI − €17.56;− €1.30] and 2016 [− €12.93; 95% CI − €25.37;− €0.48]. Although we used complex adjustment, residual bias cannot be completely ruled out.

Conclusion
Influenza and pneumococcal vaccination in the elderly can be cost-saving in selective seasons and health care divisions. As cost effects vary, interpretation of findings is partly challenging.
Did the COVID-19 pandemic change the willingness to pay for an early warning system for infectious diseases in Europe?
Authors: Himmler Sebastian , van Exel Job , Brouwer Werner 
Published: July 2021

AbstractThe COVID-19 pandemic highlights the need for effective infectious disease outbreak prevention. This could entail installing an integrated, international early warning system, aiming to contain and mitigate infectious diseases outbreaks. The amount of resources governments should spend on such preventive measures can be informed by the value citizens attach to such a system. This was already recognized in 2018, when a contingent valuation willingness to pay (WTP) experiment was fielded, eliciting the WTP for such a system in six European countries. We replicated that experiment in the spring of 2020 to test whether and how WTP had changed during an actual pandemic (COVID-19), taking into account differences in infection rates and stringency of measures by government between countries. Overall, we found significant increases in WTP between the two time points, with mean WTP for an early warning system increasing by about 50% (median 30%), from around €20 to €30 per month. However, there were marked differences between countries and subpopulations, and changes were only partially explained by COVID-19 burden. We discuss possible explanations for and implication of our findings.
Looking at the big picture: worldwide population structure and range expansion of the cosmopolitan pest Ceratitis capitata (Diptera, Tephritidae)
Authors: Deschepper Pablo , Todd Terrance N. , Virgilio Massimiliano , De Meyer Marc , Barr Norman B. , Ruiz-Arce Raul 
Published: July 2021

AbstractThe Mediterranean fruit fly,Ceratitis capitata(Weidemann), is considered one of the most significant tephritid pest species worldwide and is an exotic species in most of its range. Here, we investigated polymorphism at 14 microsatellite loci for a total of 126 populations ofC. capitatafrom six geographical regions, applying network theory and cluster analyses. Analyses revealed nine distinct modules for the Central American region and one in each of the remaining five regions. Bayesian cluster analysis revealed that the highest level of genetic partitioning corresponds with the presence of 3 well-defined genetic clusters. Our results confirm the African origin for Mediterranean populations based on genetic diversity and suggest a direct invasion ofC. capitatafrom the Mediterranean to Central-America. South American populations show links with Central-America, but also exhibit indications of direct admixture with the European cluster. Additionally, the network analysis proposes a South American origin for the Madeiran and Hawaiian flies. Cluster analysis corroborates the hypothesis of a Mediterranean origin for Australian samples. Our work provides novel insights regarding the migration history of Medfly worldwide.
The Treachery of Images in the Digital Sovereignty Debate
Authors: Ruohonen Jukka 
Published: July 2021

AbstractThis short theoretical and argumentative essay contributes to the ongoing deliberation about the so-called digitalfug sovereignty, as pursued particularly in the European Union (EU). Drawing from classical political science literature, the essay approaches the debate through paradoxes that arise from applying classical notions of sovereignty to the digital domain. With these paradoxes and a focus on the Peace of Westphalia in 1648, the essay develops a viewpoint distinct from the conventional territorial notion of sovereignty. Accordingly, the lesson from Westphalia has more to do with the capacity of a state to govern. It is also this capacity that is argued to enable the sovereignty of individuals within the digital realm. With this viewpoint, the essay further advances another, broader, and more pressing debate on politics and democracy in the digital era.
Does signaling childcare support on job applications reduce the motherhood penalty?
Authors: Bedi Arjun , Majilla Tanmoy , Rieger Matthias 
Published: July 2021

AbstractThere is substantial evidence that due to perceived childcare obligations, mothers are disadvantaged in labor markets. To what extent can childcare support ameliorate such a disadvantage? To answer this question, we ran a CV experiment in a large Indian city and examined whether indicating access to childcare support in a CV may offset the motherhood penalty associated with labor market entry. We randomly varied motherhood, as well as access to childcare in CVs sent to online applications for service sector jobs in Delhi. Indicating motherhood on a CV led to a 57% or 20 percentage point reduction in callback rates for interviews as compared to non-mothers. A simple indication of access to childcare support offsets the motherhood penalty by 20% or 4 percentage points. We interpret the findings in the Indian context and with respect to potential sources of discrimination.
Anatomical variants of pulmonary segments and uni-portal thoracoscopic segmentectomy for lung cancer in a patient with Kartagener syndrome: a case report
Authors: Zhou Di , Tian Ye , Lu Yao , Yang Xueying 
Published: July 2021

AbstractSitus inversus totalis (SIT) is an extremely uncommon congenital disease where the major organs of the body are transposed through the sagittal plane. Kartagener syndrome is a complication of SIT with immotility of bronchial cilia, bronchiectasis, and chronic sinusitis. There is no report describing patients with Kartagener syndrome who accept uni-portal segmentectomies for lung cancer in past studies. Here we report a 74-year-old female patient with both Kartagener syndrome and a small early-stage lung cancer lesion located in the apical segment of the left upper lobe (LS1). The pulmonary segment anatomy of the left upper lobe in this case, which had very rare variants, was presented and interpreted in detail. This patient underwent an anatomic segmentectomy to the LS1 and a partial excision to the left middle lobe with bronchiectasis through a single 3 cm length incision. We believe that the case can give surgeons some experience and inspiration.
PCR vs karyotype for CVS and amniocentesis—the experience at one tertiary fetal medicine unit
Authors: Finnegan Catherine , Smyth Suzanne , Smith Orla , Flood Karen , Dalrymple Jane , Breathnach Fionnuala M. , Malone Fergal D. 
Published: July 2021

Abstract
Purpose
Despite the rise of non-invasive screening tests for fetal aneuploidy, invasive testing during pregnancy remains the definitive diagnostic tool for fetal genetic anomalies. Results are rapidly available with polymerase chain reaction (PCR) tests, but cases have been reported whereby initial results were not confirmed after pregnancy termination and the fetal karyotype was ultimately normal. We sought to examine the potential discordance between PCR and karyotype for fetal aneuploidy.

Methods
The results from all amniocentesis and CVS tests performed over a 6-year period in a large tertiary level fetal medicine unit were reviewed. The results of PCR and karyotype were recorded and discrepancies examined. Pregnancy outcomes were also recorded.

Results
A total of 1222 invasive tests were performed (716 amniocentesis and 506 CVS). Within the cohort having amniocentesis, 11 had discrepant results (normal QF-PCR result but with a subsequent abnormal karyotype). There was 1 case among this group which QF-PCR should have identified. Within the CVS group, 7 patients had discrepant results. All had a diploid QF-PCR and would not have been identified as abnormal by it.

Conclusion
PCR can be reliably used to determine aneuploidy of chromosomes 13, 18, and 21. However, in cases of sex chromosome aneuploidy, its performance is less reliable and warrants waiting for a complete karyotype. Given such discordance, we advise waiting for karyotype for all invasive tests performed in the presence of a normal ultrasound before advising a patient of a diploid QF-PCR result or potentially terminating a normal pregnancy.
Ptotic Right Retro-renal Liver Lobe Injury During Supine Percutaneous Nephrolithotomy Managed by Hemostatic Sponge
Authors: Üntan İbrahim , Sabur Volkan 
Published: July 2021

AbstractPercutaneous nephrolithotomy is an invasive procedure applied to large and complex stones in the prone or supine position. Various complications—but mostly fever or bleeding—can be seen during and after the procedure. Neighboring organ injuries are rare during access. Liver injuries are rarely seen and have a better clinical prognosis than other organ injuries. We present the management of liver injury with ptosis of the retro-renal right lobe as a complication during supine percutaneous nephrolithotomy.
Management of environmental streaming data to optimize Arctic shipping routes
Authors: Zhang Zhihua , Crabbe M. James C. 
Published: July 2021

AbstractDynamic accurate predictions of Arctic sea ice, ocean, atmosphere, and ecosystem are necessary for safe and efficient Arctic maritime transportation; however a related technical roadmap has not yet been established. In this paper, we propose a management system for trans-Arctic maritime transportation supported by near real-time streaming data from air-space-ground-sea integrated monitoring networks and high spatio-temporal sea ice modeling. As the core algorithm of integrated monitoring networks, a long short-term memory (LSTM) neural network is embedded to improve Arctic sea ice mapping algorithms. Since the LSTM is localized in time and space, it can make full use of streaming data characteristics. The sea ice–related parameters from satellite remote sensing raw data are used as the input of the LSTM, while streaming data from shipborne radar networks and/or buoy measurements are used as training datasets to enhance the accuracy and resolution of environmental streaming data from outputs of LSTM. Due to large size of streaming data, the proposed management system of trans-Arctic shipping should be built on a cloud distribution platform using existing wireless communications networks among vessels and ports. Our management system will be used by the ongoing European Commission Horizon 2020 Programme “ePIcenter.”
Farm wage and Rice Price dynamics in Bangladesh
Authors: Hassan Md. Fuad , Kornher Lukas 
Published: July 2021

AbstractEmpirical findings explaining the wage-price nexus in Bangladesh are diverse and conflicting. A proper understanding of the relationship between food prices and farm wages is essential for planning policies in support of the wellbeing and food security of the rural poor. In exploring the link between food prices and rising agricultural wages, this study analyzes the dynamic relations between those two by using monthly data from 1994 to 2014. A standard vector error correction model (VECM) is implemented to determine the short-run and long-run relationships between wages and food prices in eight divisions in Bangladesh. In addition, we use autoregressive distributed lag (ARDL) models to estimate the pass-through coefficients and to compare the short-run effects of rice price and urban wage shocks on agricultural wages. We find statistical evidence for a structural break between January 2007 and January 2009 in the relationships of the variables in all divisions. Different to the period until 2007/2009, after the structural break, in six out of eight divisions, rice price shocks do not transmit to the farm wages in the short-run. Moreover, our findings show that in the long-run food prices have become less influential in explaining the changes in farm wages while the influence of urban wages has become stronger in some divisions.
Fretting Wear and Scratch Resistance of Cold-Sprayed Pure Cu and Ti
Authors: Váz Rodolpho F. , Silvello Alessio , Cavalière Pasquale D. , Dosta Sergi , Cano Irene G. , Capodieci Laura , Rizzo Antonella , Valerini Daniele 
Published: July 2021

AbstractThe paper analyses the fretting and wear behavior of pure copper and pure titanium coatings realized through cold spray. The coatings were designed and produced by employing processing conditions leading to minimum porosity and high hardness; these conditions were 700 °C and 40 bar for Ti powders and 400 °C and 30 bar for Cu ones. The low porosity and high strength materials led to high resistance to wear damaging through the optimal energy dissipation upon fretting. Due to the sprayed particles deformation mode, the sprayed materials show non-uniform hardening along the deposition distance. As a matter of fact, hardness varied in the range 3.7–4.2 GPa for Ti coatings and 1.5–2 GPa for the Cu ones depending on the distance from the substrate and on the coatings thickness. This influenced the materials properties and the response to the wear damaging. This was demonstrated by the scratch tests performed on coatings with different thicknesses. Those coatings sprayed in major thickness revealed the best wear resistance due to the deformation hardening. The harder coatings also revealed brittle fracture at the experienced highest loads.
A review of deep-neural automated essay scoring models
Authors: Uto Masaki 
Published: July 2021

AbstractAutomated essay scoring (AES) is the task of automatically assigning scores to essays as an alternative to grading by humans. Although traditional AES models typically rely on manually designed features, deep neural network (DNN)-based AES models that obviate the need for feature engineering have recently attracted increased attention. Various DNN-AES models with different characteristics have been proposed over the past few years. To our knowledge, however, no study has provided a comprehensive review of DNN-AES models while introducing each model in detail. Therefore, this review presents a comprehensive survey of DNN-AES models, describing the main idea and detailed architecture of each model. We classify the AES task into four types and introduce existing DNN-AES models according to this classification.
Von der Geschichtsphilosophie zur Formalpragmatik
Authors: Ellmers Sven 
Published: July 2021

ZusammenfassungDie gegenwärtige Debatte über die normativen Grundlagen Kritischer Theorie lässt sich nur vor dem Hintergrund ihrer Geschichte verstehen: Die Defizite in den Konzeptionen der 1. und 2. Generation strukturieren das Feld der Optionen, die heute noch als aussichtsreich gelten können. Der Blick zurück schärft den Blick nach vorn. Im ersten Teil des Beitrags werde ich deshalb die Hauptthesen, ethischen Implikationen und Einseitigkeiten von HorkheimersZur Kritik der instrumentellen Vernunftdarstellen. Im zweiten Teil werde ich die (von Horkheimer beiläufig angedachte und) von Habermas ausgearbeitete These diskutieren, dass der Sprache das nicht-instrumentelle Telos der Verständigung innewohnt. Zudem werde ich zeigen, dass es Habermas nicht gelingt, den für seine Diskursethik zentralen Universalisierungsgrundsatz abzuleiten. Wie sich die Begründungsprobleme bei Horkheimer und Habermas auf die gegenwärtige Debatte auswirken, werde ich im dritten Teil besprechen.
Worldwide increases in adolescent loneliness
Authors: Twenge Jean M. , Haidt Jonathan , Blake Andrew B. , McAllister Cooper , Lemon Hannah , Le Roy Astrid 
Published: July 2021

AbstractIntroductionSeveral studies have documented increases in adolescent loneliness and depression in the U.S., UK, and Canada after 2012, but it is unknown whether these trends appear worldwide or whether they are linked to factors such as economic conditions, technology use, or changes in family size.MethodsThe Programme for International Student Assessment (PISA) survey of 15‐ and 16‐year‐old students around the world included a 6‐item measure of school loneliness in 2000, 2003, 2012, 2015, and 2018 (n = 1,049,784, 51% female) across 37 countries.ResultsSchool loneliness increased 2012–2018 in 36 out of 37 countries. Worldwide, nearly twice as many adolescents in 2018 (vs. 2012) had elevated levels of school loneliness. Increases in loneliness were larger among girls than among boys and in countries with full measurement invariance. In multi‐level modeling analyses, school loneliness was high when smartphone access and internet use were high. In contrast, higher unemployment rates predicted lower school loneliness. Income inequality, GDP, and total fertility rate (family size) were not significantly related to school loneliness when matched by year. School loneliness was positively correlated with negative affect and negatively correlated with positive affect and life satisfaction, suggesting the measure has broad implications for adolescent well‐being.ConclusionsThe psychological well‐being of adolescents around the world began to decline after 2012, in conjunction with the rise of smartphone access and increased internet use, though causation cannot be proven and more years of data will provide a more complete picture.
Psychotropic medication use and academic performance in adolescence: A cross‐lagged path analysis
Authors: Bortes Cristian , Landstedt Evelina , Strandh Mattias 
Published: July 2021

ABSTRACTIntroductionThe study investigated the directionality of associations between mental health problems and school grades across two timepoints (T1 and T2) during mid to late adolescence; in school year 9 (ages 15–16) and school year 12 (ages 17–18). The study also investigated variation in the associations as a function of gender and across socioeconomic groups.MethodsLongitudinal data from several Swedish administrative registers were utilised. Information on prescribed psychotropic drugs was used as a proxy for mental health problems, and teacher‐assigned school grades were used to measure academic performance. The study sample comprised 85 186 individuals (50.7% girls) born in 1991 who were alive and resident in Sweden in 2010. Directions of associations were analysed by estimating a series of cross‐lagged path models.ResultsThe model with the best fit to data showed that higher school grades at T1 were associated with relatively lower rates of mental health problems by T2, for both boys and girls, mainly in socioeconomic groups with the highest educated parents. This association was equal in size across all of the socioeconomic groups that were explored.ConclusionsPerforming well in school is equally important for boys' and girls’ subsequent mental health, but only among adolescents in socioeconomic groups with the highest educated parents. The results underscore the importance of promoting opportunities for youth to do as well as they can in school.
Changes in the adult consequences of adolescent mental ill-health: findings from the 1958 and 1970 British birth cohorts
Authors: Thompson Ellen J. , Richards Marcus , Ploubidis George B. , Fonagy Peter , Patalay Praveetha 
Published: July 2021

AbstractBackgroundAdolescent mental health difficulties are increasing over time. However, it is not known whether their adulthood health and socio-economic sequelae are changing over time.MethodsParticipants (N= 31 349) are from two prospective national birth cohort studies: 1958 National Child Development Study (n= 16 091) and the 1970 British Cohort Study (n= 15 258). Adolescent mental health was operationalised both as traditional internalising and externalising factors and a hierarchical bi-factor. Associations between adolescent psychopathology and age 42 health and wellbeing (mental health, general health, life satisfaction), social (cohabitation, voting behaviour) and economic (education and employment) outcomes are estimated using linear and logistic multivariable regressions across cohorts, controlling for a wide range of early life potential confounding factors.ResultsThe prevalence of adolescent mental health difficulties increased and their associations with midlife health, wellbeing, social and economic outcomes became more severe or remained similar between those born in 1958 and 1970. For instance, a stronger association with adolescent mental health difficulties was found for those born in 1970 for midlife psychological distress [odds ratio (OR) 1970 = 1.82 (1.65–1.99), OR 1958 = 1.60 (1.43–1.79)], cohabitation [OR 1970 = 0.64 (0.59–0.70), OR 1958 = 0.79 (0.72–0.87)], and professional occupations [OR 1970 = 0.75 (0.67–0.84), OR 1958 = 1.05 (0.88–1.24)]. The associations of externalising symptoms with later outcomes were mainly explained by their shared variance with internalising symptoms.ConclusionThe widening of mental health-based inequalities in midlife outcomes further supports the need to recognise that secular increases in adolescent mental health symptoms is a public health challenge with measurable negative consequences through the life-course. Increased public health efforts to minimise adverse outcomes are needed.