bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
Authors: Yuan F. , Chen J. , Liu F. , Dang Y. C. , Kong Q. T. , Sang H. 
Published: November 2021

Abstract
Background
Mucormycosis is a rare fungal infection occurring chiefly in the lung or the rhino-orbital-cerebral compartment, particularly in patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. are the most common cause of mucormycosis.

Case presentation
We report a case of pulmonary mucormycosis caused by Rhizopus microsporus in a young patient with diabetes but no other apparent risk factors. The diagnosis mainly relied on clinical manifestation, positive pulmonary tissue biopsy, and fungal culture. The patient was successfully treated with posaconazole oral suspension and remains asymptomatic at one-year follow-up.

Conclusions
Pulmonary mucormycosis is a life-threatening condition and posaconazole is an effective treatment for pulmonary mucormycosis caused by Rhizopus microspores.
Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis
Authors: Liu Qiao , Qin Chenyuan , Liu Min , Liu Jue 
Published: November 2021

Abstract
Background
To date, coronavirus disease 2019 (COVID-19) becomes increasingly fierce due to the emergence of variants. Rapid herd immunity through vaccination is needed to block the mutation and prevent the emergence of variants that can completely escape the immune surveillance. We aimed to systematically evaluate the effectiveness and safety of COVID-19 vaccines in the real world and to establish a reliable evidence-based basis for the actual protective effect of the COVID-19 vaccines, especially in the ensuing waves of infections dominated by variants.

Methods
We searched PubMed, Embase and Web of Science from inception to July 22, 2021. Observational studies that examined the effectiveness and safety of SARS-CoV-2 vaccines among people vaccinated were included. Random-effects or fixed-effects models were used to estimate the pooled vaccine effectiveness (VE) and incidence rate of adverse events after vaccination, and their 95% confidence intervals (CI).

Results
A total of 58 studies (32 studies for vaccine effectiveness and 26 studies for vaccine safety) were included. A single dose of vaccines was 41% (95% CI: 28–54%) effective at preventing SARS-CoV-2 infections, 52% (31–73%) for symptomatic COVID-19, 66% (50–81%) for hospitalization, 45% (42–49%) for Intensive Care Unit (ICU) admissions, and 53% (15–91%) for COVID-19-related death; and two doses were 85% (81–89%) effective at preventing SARS-CoV-2 infections, 97% (97–98%) for symptomatic COVID-19, 93% (89–96%) for hospitalization, 96% (93–98%) for ICU admissions, and 95% (92–98%) effective for COVID-19-related death, respectively. The pooled VE was 85% (80–91%) for the prevention of Alpha variant of SARS-CoV-2 infections, 75% (71–79%) for the Beta variant, 54% (35–74%) for the Gamma variant, and 74% (62–85%) for the Delta variant. The overall pooled incidence rate was 1.5% (1.4–1.6%) for adverse events, 0.4 (0.2–0.5) per 10 000 for severe adverse events, and 0.1 (0.1–0.2) per 10 000 for death after vaccination.

Conclusions
SARS-CoV-2 vaccines have reassuring safety and could effectively reduce the death, severe cases, symptomatic cases, and infections resulting from SARS-CoV-2 across the world. In the context of global pandemic and the continuous emergence of SARS-CoV-2 variants, accelerating vaccination and improving vaccination coverage is still the most important and urgent matter, and it is also the final means to end the pandemic.

Graphical Abstract
Enhancing the quality of communication of cellular networks using big data applications
Authors: Saeed Mozamel Musa , Alsharidah Mohammed 
Published: November 2021

AbstractBoth software-defined networking and big data have gained approval and preferences from both industry and academia. These two important realms have conventionally been addressed independently in wireless cellular networks. The discussion taken into consideration in this study was to analyze the wireless cellular technologies with the contrast of efficient and enhanced spectral densities at a reduced cost. To accomplish the goal of this study, Welch's method has been used as the core subject. With the aid of previous research and classical techniques, this study has identified that the spectral densities can be enhanced at reduced costs with the help of the power spectral estimation methods. The Welch method gives the result on power spectrum estimation. By reducing the effect of noise, the Welch method is used to calculate the power spectral density of a signal. When data length is increased, Welch's method is considered the best as a conclusion to this paper because excellent results are yielded by it in the area of power spectral density estimation.
Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping
Authors: Whi Wonseok , Choi Hongyoon , Paeng Jin Chul , Cheon Gi Jeong , Kang Keon Wook , Lee Dong Soo 
Published: November 2021

Abstract
Background
The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation without quantitative analysis in clinical practice. In this study, we aimed to develop a fully automated quantitative interpretation pipeline of brain volume from an oncology PET image.

Method
We retrospectively collected 500 oncologic [18F]FDG-PET scans for training and validation of the automated brain extractor. We trained the model for extracting brain volume with two manually drawn bounding boxes on maximal intensity projection images. ResNet-50, a 2-D convolutional neural network (CNN), was used for the model training. The brain volume was automatically extracted using the CNN model and spatially normalized. For validation of the trained model and an application of this automated analytic method, we enrolled 24 subjects with small cell lung cancer (SCLC) and performed voxel-wise two-sample T test for automatic detection of metastatic lesions.

Result
The deep learning-based brain extractor successfully identified the existence of whole-brain volume, with an accuracy of 98% for the validation set. The performance of extracting the brain measured by the intersection-over-union of 3-D bounding boxes was 72.9 ± 12.5% for the validation set. As an example of the application to automatically identify brain abnormality, this approach successfully identified the metastatic lesions in three of the four cases of SCLC patients with brain metastasis.

Conclusion
Based on the deep learning-based model, extraction of the brain volume from whole-body PET was successfully performed. We suggest this fully automated approach could be used for the quantitative analysis of brain metabolic patterns to identify abnormalities during clinical interpretation of oncologic PET studies.
Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
Authors: Hasabo Elfatih A. , Ayyad Fatima A. , Alam Eldeen Sara A. M. , Noureldaim Malaz K. , Abdallah Tibyan A. , Ahmed Yousra T. , Badi Safaa , Khalid Waleed K. , Mirghani Hind A. , Mohammed Yossra A. , Alkhider Lubaba A. , Hamad Saada A. , Tagelseed Amna M. , Elsheikh Ethar H. A. , Khalid Noon H. , Mohammed Samia A. , Elmobark Sara O. , Ali Ola O. , Mohammed Ali Duaa A. , Muneer Mohamed S. , Awadalla Heitham , Malik Elfatih M. 
Published: November 2021

Abstract
Background
Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudanese patients diagnosed with COVID-19.

Methods
This retrospective observational study is based on documented files that included patients diagnosed with COVID-19 in seven selected hospitals inside Khartoum. Clinical manifestations, complications and outcomes were extracted from patients’ records using an extraction form designed for this study.

Results
Data of 243 patients diagnosed with COVID-19 were analyzed. The mean (SD) age in years was 55.8 (18.4). Out of 116 participants, 27 of them (23.3%) had severe disease, 15 (12.9%) were critically ill. 67.5% of patients were admitted to the hospital within 7 days from onset of symptoms; most of them were admitted to the wards (n = 140,72.5%). Fever (83.2%), cough (70.7%), and shortness of breath (69.2%) were the most commonly recorded clinical manifestations. Sepsis (9.8%) and acidosis (7.8%) were the most frequently reported complications. Death was the final outcome in 21.4% (56/243). Older age and presence of diabetes were found significantly associated with in-hospital death. The laboratory results showed high CRP in 85.6% (119/139), high ferritin in 88.9% (24/27), lactate dehydrogenase had a median of 409.0 (359–760), D-dimer had a median of 3.3 (1.2–16. 6), and 53/105 (50.5%) had low albumin.

Conclusions
Fever was the most mentioned sign among the participants, followed by fatigue. Cough and shortness of breath were the most commonly recorded pulmonary symptoms manifested. Our study showed multiple variables were associated with in-hospital death. The mortality rate was high among severe and critically ill patients diagnosed with COVID-19.
Isolated traumatic acute subdural haematoma: outcome in relation to age, Glasgow Coma Scale, and haematoma thickness
Authors: Ragaee Mohamed A. , Mahmoud Radwan Nouby , Alghriany Mohamed Ahmed , Abd El-Ghani Wael M. A. 
Published: November 2021

Abstract
Background
Traumatic acute subdural haematoma occurs in about 10–20% of patients with severe head injuries. This study aims to investigate the relation between outcome and the age, Glasgow Coma Scale on admission as well as haematoma thickness upon admission CAT scan.
This is a prospective observational clinical trial study of 39 patients with isolated traumatic acute subdural haematomas treated with conservative or surgical procedures during a one-year study period.

Results
There was a statistically significant relation between Glasgow Outcome Score and both age of the patients and Glasgow Coma Scale upon admission. However, there was a non-statistically significant relationship between Glasgow Outcome Score and haematoma thickness upon admission CAT scan.

Conclusions
Age of the patients with traumatic acute subdural haematoma as well as Glasgow Coma Scale upon admission are essential predictors of the outcome.
Clinical trial registration details: Name of the registry: Traumatic Acute Subdural Haematoma: Management and Outcome. Trial registration number: NCT03971240. Date of registration: June 3, 2019. URL of trial registry record: https://clinicaltrials.gov/ct2/show/record/NCT03971240?term=Mohamed+Ahmed+Alghriany&draw=2&rank=1.
A case of a different approach for difficult airway: transorbital endotracheal intubation
Authors: Dereli Ozge , Sahutoglu Cengiz , Balcioglu Taner 
Published: November 2021

Abstract
Background
In patients who have undergone head and neck surgery and received radiotherapy, airway management presents serious difficulties for the anesthesiologist.

Case presentation
We report a case of a 23-year-old male patient undergoing an emergency operation due to a rhabdomyosarcoma pressed spinal cord that loss of muscle strength and loss of sensation developed below the level of thoracal 6–7 vertebrae. Because of the previous radiotherapy reducing the mouth opening (less than 1 cm), the patient was intubated by transorbital pathway without any difficulty.

Conclusions
Transorbital intubation seems to be a safe method and may be a good alternative to difficult airway in the patient undergoing orbital exenteration.
Modulatory effect of Persea Americana oil against diethylnitrosamine-induced hepatotoxicity in rats: a proposed mechanism
Authors: Abozaid Omayma A. R. , Anees Lobna M. , Abdel-Hamed Gehan R. 
Published: November 2021

Abstract
Background
The purpose of this study was to investigate the effectiveness of Persea Americana (avocado) oil against diethylnitrosamine (DEN)-induced hepatotoxicity in rats.

Methods
For the induction of hepatotoxicity, DEN was administrated orally in a dose of 20 mg/kg B.wt for 6 successive weeks, and then the animals were gavaged with Persea Americana oil in a dose of 4 mL/kg b.wt. daily for another 6 weeks. Serum caspase-3 activity and poly (ADP-ribose) polymerase-1 (PARP-1) levels were estimated; in addition to gene expressions for NADPH oxidase, inducible nitric oxide synthase (iNOS), Bcl-2, and Bax were detected.

Results
The DEN-intoxicated group exhibited a remarkable increase in NADPH oxidase and iNOS expression combined with over-activation of PARP-1 and increased antiapoptotic Bcl-2 gene expression, whereas the expression of apoptotic biomarkers significantly decreased. On the other hand, treatment with Persea Americana oil significantly suppressed the elevated levels of hepatic enzymes and improved histopathological alterations in the liver. Furthermore, these groups displayed marked downregulation in NADPH oxidase and iNOS expressions. Persea Americana oil suppressed the expression of the antiapoptotic Bcl-2, activated the intrinsic mitochondrial apoptosis pathway through upregulation of pro-apoptotic Bax, and induced an obvious increase in caspase-3 activity. Moreover, Persea Americana oil administration markedly inhibited the activity of PARP-1.

Conclusions
This study indicated the promising potential of Persea Americana oil against DEN-induced hepatic injury through its anti-oxidative activity and pro-apoptotic effect via caspase activation and PARP-1 inhibition.
Sterols from Jatropha tanjorensis leaves exhibit anti-inflammatory potential: in vitro and in silico studies
Authors: Omoboyowa Damilola Alex 
Published: November 2021

Abstract
Background
Inflammation has continued to raise global challenges and Jatropha tanrogenesis (JT) is used traditionally for its management. In this study, the in silico and in vitro anti-inflammatory potential of bioactive sterols were investigated. The active compounds of ethanol extract of JT leaves were identified using Gas chromatography-mass spectrometry (GC.MS) followed by molecular docking against COX-1 and COX-2 using maestro Schrödinger and pharmacokinetic profile prediction using webserver tools. The in vitro anti-inflammatory and anti-oxidantive potentials were investigated using standard protocols.

Results
GC–MS analysis of ethanol extract of JT leaves revealed the presence of eight (8) compounds, the molecular docking analysis of these compounds demonstrated varying degrees of binding affinities against the target proteins. The extract exhibit concentration dependent anti-oxidant activity with IC50 of 106.383 and 6.00 Fe2+E/g for DPPH and FRAP respectively. The extract showed significant (P < 0.05) reduction in percentage inhibition of hemolysis at 200 µg/ml while non-significant (P > 0.05) increase was observed at 600 and 1000 µg/ml compared to 200 µg/ml of diclofenac sodium. At lower concentration of 25 and 50 µg/ml, percentage inhibition of albumin denaturation was significantly (P < 0.05) higher compared to 200 µg/ml of diclofenac sodium. Drug likeness prediction and ADME/toxicity screening showed that the bioactive compounds possess no side effects.

Conclusion
The results obtained in this study suggested that, JT leaves possess anti-inflammatory activity and could be used as a source of new drug.
On rational Krylov and reduced basis methods for fractional diffusion
Authors: Danczul Tobias , Hofreither Clemens 
Published: November 2021

Abstract
We establish an equivalence between two classes of methods for solving fractional diffusion problems, namely, Reduced Basis Methods (RBM) and Rational Krylov Methods (RKM). In particular, we demonstrate that several recently proposed RBMs for fractional diffusion can be interpreted as RKMs. This changed point of view allows us to give convergence proofs for some methods where none were previously available.
We also propose a new RKM for fractional diffusion problems with poles chosen using the best rational approximation of the function z
−s
with z ranging over the spectral interval of the spatial discretization matrix. We prove convergence rates for this method and demonstrate numerically that it is competitive with or superior to many methods from the reduced basis, rational Krylov, and direct rational approximation classes. We provide numerical tests for some elliptic fractional diffusion model problems.
Effect of the Repetitions-In-Reserve Resistance Training Strategy on Bench Press Performance, Perceived Effort, and Recovery in Trained Men
Authors: Mangine Gerald T. , Serafini Paul R. , Stratton Matthew T. , Olmos Alex A. , VanDusseldorp Trisha A. , Feito Yuri 
Published: November 2021

Abstract
Mangine, GT, Serafini, PR, Stratton, MT, Olmos, AA, VanDusseldorp, TA, and Feito, Y. Effect of the repetitions-in-reserve resistance training strategy on bench press performance, perceived effort, and recovery in trained men. J Strength Cond Res 36(1): 1–9, 2022—This study examined the effects of the repetitions-in-reserve (RIR) strategy on resistance exercise performance, perceived effort, and recovery. Fourteen resistance-trained men (24.6 ± 3.0 years, 176 ± 5 cm, 85.7 ± 14.0 kg) completed 2 bench press protocols in a randomized crossover fashion. The protocols consisted of 4 sets at 80% of 1 repetition maximum (1RM) to a self-reported 3-RIR and a fifth set to failure or all 5 sets to failure (0-RIR). Barbell kinetics (velocity, rate of force development, and impulse), repetition volume, total work, and ratings of perceived exertion (RPE) were quantified on each set. Barbell kinetics were reassessed during one set of 3 repetitions at 80% 1RM completed at 24-hour, 48-hour, and 72-hour postexercise. Blood samples were collected before and after exercise at 6 hours, 24 hours, 48 hours, and 72 hours and analyzed for concentrations of creatine kinase (CK). Separate, 2-way repeated-measures analysis of variance revealed significant interactions (p < 0.001) where 3-RIR better maintained repetitions and work at greater average velocity (+0.6 m·s−1) and lower RPE (0-RIR = 10; 3-RIR = 8.2) across all sets. No differences were seen between conditions for CK at 6 hours postexercise (3-RIR: 32.2 ± 55.3%; 0-RIR: 40.8 ± 66.0%) or for CK and barbell kinetics at 24 hours to 72 hours postexercise. Although no differences were seen for recovery, the RIR strategy enabled work to be better sustained across sets at a lower perceived effort and higher average velocity. This strategy could be used to manage fatigue and better sustain effort and volume during a resistance training session.
Handgrip Strength Asymmetry and Weakness Are Associated With Future Morbidity Accumulation in Americans
Authors: Klawitter Lukus , Vincent Brenda M. , Choi Bong-Jin , Smith Joseph , Hammer Kimberly D. , Jurivich Donald A. , Dahl Lindsey J. , McGrath Ryan 
Published: November 2021

Abstract
Klawitter, L, Vincent, BM, Choi, BJ, Smith, J, Hammer, KD, Jurivich, DA, Dahl, LJ, and McGrath, R. Handgrip strength asymmetry and weakness are associated with future morbidity accumulation in americans. J Strength Cond Res 36(1): 106–112, 2022—Identifying strength asymmetries in physically deconditioned populations may help in screening and treating persons at risk for morbidities linked to muscle dysfunction. Our investigation sought to examine the associations between handgrip strength (HGS) asymmetry and weakness on accumulating morbidities in aging Americans. The analytic sample included 18,506 Americans aged ≥50 years from the 2006–2016 Health and Retirement Study. Handgrip strength was measured on each hand with a handgrip dynamometer, and persons with an imbalance in strength >10% between hands had HGS asymmetry. Men with HGS <26 kg and women with HGS <16 kg were considered as weak. Subjects reported the presence of healthcare provider–diagnosed morbidities: hypertension, diabetes, cancer, chronic lung disease, cardiovascular disease, stroke, arthritis, and psychiatric problems. Covariate-adjusted ordinal generalized estimating equations analyzed the associations for each HGS asymmetry and weakness group on future accumulating morbidities. Of those included in our study, subjects at baseline were aged 65.0 ± 10.2 years, 9,570 (51.7%) had asymmetric HGS, and 996 (5.4%) were weak. Asymmetry alone and weakness alone were associated with 1.09 (95% confidence interval [CI]: 1.04–1.14) and 1.27 (CI: 1.11–1.45) greater odds for future accumulating morbidities, respectively. Having both HGS asymmetry and weakness was associated with 1.46 (CI: 1.29–1.65) greater odds for future accumulating morbidities. Handgrip-strength asymmetry, as another potential indicator of impaired muscle function, is associated with future morbidity status during aging. Exercise professionals and related practitioners should consider examining asymmetry and weakness with handgrip dynamometers as a simple and noninvasive screening method for helping to determine muscle dysfunction and future chronic disease risk.
Importance of Transverse Plane Flexibility for Proficiency in Golf
Authors: McHugh Malachy P. , O'Mahoney Catherine A. , Orishimo Karl F. , Kremenic Ian J. , Nicholas Stephen J. 
Published: November 2021

Abstract
McHugh, MP, O'Mahoney, CA, Orishimo, KF, Kremenic, IJ, and Nicholas, SJ. Importance of transverse plane flexibility for proficiency in golf. J Strength Cond Res 36(2): e49–e54, 2022—The extent to which the flexibility requirements for golf proficiency vary between the planes of motion has not been examined. The purpose of this study was to compare flexibility between proficient and average golfers with the hypothesis that proficient golfers have greater transverse plane flexibility than average golfers, with no differences in the sagittal and frontal planes. Twenty-five male golfers were categorized as proficient (handicap ≤5, n = 13) or average (handicap 10–20, n = 12). Fourteen flexibility tests were performed (4 shoulder tests, 4 trunk tests, and 6 hip tests) with tests in all 3 planes of motion for each body segment. In addition, trunk motion, pelvic motion, and hip motion during the golf swing were assessed with high-speed motion analysis. Ball speed and shot distance were recorded with a golf simulator. Proficient golfers had significantly better flexibility than average golfers in the transverse plane (shoulder p = 0.021, trunk p = 0.003, and hip p < 0.0001), with no differences in the sagittal plane or frontal plane (plane of motion by golf proficiency p = 0.0001). Transverse plane hip flexibility accounted for 48% of the variability in ball speed (p < 0.0001) and 45% of the variability in total distance (p = 0.001). During the golf swing, proficient golfers had greater separation between the pelvis and the trunk (x-factor) than average golfers (p = 0.002). In conclusion, transverse plane flexibility in the trunk and hips is an important requirement for golf proficiency. Sagittal plane flexibility and frontal plane flexibility were unrelated to proficiency. Developing and maintaining trunk and hip rotation flexibility is important for optimizing performance.