bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between electrical myocardial instability and postinfarction remodeling in patients with ST-segment elevation myocardial infarction
Authors: Oleynikov V. E. , Barmenkova Yu. A. , Dushina E. V. , Golubeva A. V. 
Published: November 2021

Aim To study the clinical value of markers for myocardial electrical instability in combination with echocardiographic parameters for predicting the risk of cardiovascular complications (CVC) in the postinfarction period.Material and methods This study included 118 patients with ST segment elevation myocardial infarction (STEMI) and hemodynamically significant stenosis of one coronary artery. A percutaneous coronary intervention (PCI) with stenting of the infarct-related artery was performed for all patients. On day 7-9 and at 24 and 48 weeks after the treatment, ECG Holter monitoring was performed, which included analyses of ventricular late potentials, dispersion of QT interval duration, heart rate turbulence (HRT) and variability (HRV), and heart chronotropic load (HCL). At baseline and during postinfarction week 12, all patients underwent echocardiography with calculation of indexes of end-diastolic volume (iEDV) and end-systolic volume (iESV) to verify the signs of left ventricular (LV) myocardial remodeling. The criteria for LV pathological remodeling included increases in iEDV >20 % and/or iESV >15 % at 12 weeks after STEMI. The group without remodeling, R(-), consisted of 79 (67 %) patients and the group with signs of LV pathological remodeling, R(+), consisted of 39 (33 %) patients. Quality of life and achieved endpoints were evaluated during 144 weeks.Results By week 48 in group R(-), the stabilization of electrical processes in the myocardium was more pronounced as indicated by a decrease in HFLA by 12 % (р=0.004) and by a fourfold increase in RMS (р=0.047). Only in this group, the baroreflex sensitivity restored; pathological ТРС decreased from 20 to 5% (p=0.002) by the end of the active treatment. Stabilization of the repolarization phase duration in various parts of the myocardium was more active in patients without pathological remodeling as shown by decreases in disp QTa (р=0.009), disp QTe (р=0.03), sd QTa (р=0.006), and sd QTe (р=0.009). This was not observed in the group R(+). The recovery of vagosympathetic balance due to leveling the sympathetic component also was more effective in the group R(-), which was reflected in increased spectral and temporal HRV indexes (р<0.05). Both groups showed reduced HCL values at 24 weeks (р=0.047 and р=0.006); however, the HCL regression remained also at 48 weeks only in the group R(-) (р=0.006). Group R(-) patients reported higher quality of life (р=0.03) than group R(+) patients. Endpoints were achieved more frequently in the group R(+): 87.1 % vs. 27.8 % (odds ratio, 11.8; 95 % confidence interval, 4.6–30.8; р=0.00001).Conclusion Pathological myocardial remodeling in early postinfarction period is associated with electrophysiological instability of the myocardium, which results in the development of CVC and low quality of life in patients with STEMI.
Analysis of the impact on the health care budget and consumers of the use of the preparation of omega-3 acid ethyl esters90 in the treatment of patients with atherogenic dyslipidemia
Authors: Frolov M. Yu. , Salasyuk A. S. , Rogov V. A. 
Published: November 2021

Aim To evaluate economic results of using omega-3 acid ethyl esters 90 for primary prevention of cardiovascular catastrophes in patients with residual hypertriglyceridemia (HTG).Material and methods The economic evaluation of using the medicine omega-3 acid ethyl esters 90 in the system of drug provision of the population of the Russian Federation was performed by analyzing the effect on the budget using a pharmacoeconomic model developed with the Microsoft Office Excel 2016 software. The effect of omega-3 acid ethyl esters 90 was evaluated in 555 643 patients with residual HGT (Moscow). The study lasted for one year. Results of the meta-analysis by A.A. Bernasconi et al. (2020) were used as a source of efficacy data. The following direct and indirect medical expenses for treatment of cardiovascular complications of residual HTG were taken into account in this study: expenses for drug therapy; expenses for therapy and rehabilitation for nonfatal complications; expenses for fatal outcomes; state support for disability; foregone per capita gross domestic product resulting from losses of earnings due to temporary incapacity to labor by people of work-able age; and salary payments for temporary incapacity to work.ResultsUsing omega-3 acid ethyl esters 90 in 555 643 patients with residual HTG will allow preventing 1 437 fatal ischemic cardiovascular complications (including 564 deaths from ischemic heart disease and 1 128 cases of myocardial infarction (MI), including 558 fatal cases of MI). Furthermore, the difference in expenses compared to the high-dose statin treatment alone will be 359 252 253 rubles or 0.32 %.Conclusion The results of this comprehensive pharmacoeconomical study showed that the use of omega-3 acid ethyl esters 90 in patients with residual HGT is an economically preferrable strategy compared to high-dose statin treatment alone and does not influence significantly the budgetary expenses as a part of the State Guarantee of Free Medical Care to the Citizens of the Russian Federation (increase in expenses by 0.32 % compared to the current practice). At the same time, the use of omega-3 acid ethyl esters 90 results in a 10% decrease in the number of fatal ischemic cardiovascular complications.
Acute coronary syndrome in patients with cancer: features of the course and the possibility of predicting hospital and long-term (6 months) periods using GDF-15, NT-proBNP, hs-CRP biomarkers
Authors: Shalenkova M. A. , Ivanov A. V. , Klimkin P. F. 
Published: November 2021

Aim To evaluate clinical features of the course of acute coronary syndrome (ACS) in patients with oncological diseases (OD) and to determine the role of biomarkers GDF-15, NT-proBNP, and hs-CRP in short-term and long-term prognoses.Material and methods In 88 patients (34 patients with ACS and OD and 54 patients with ACS without OD), complaints and historical, objective, and laboratory and instrumental data were evaluated and blood concentrations of GDF-15, NT-proBNP, and hs-CRP biomarkers were measured on the first day of hospitalization. Incidence of cardiovascular complications (CVC) and outcomes of hospital and long-term (6 months) periods were analyzed. Statistical analysis of results was performed with the Statistica 12.0, MedCalc 19.1.7 software. The level of statistical significance was р<0.05.Results In the ACS+OD group as compared to the ACS without OD group, the onset of disease was mostly atypical, with shortness of breath and/or general weakness; the ACS+OD patients more frequently had III-IV Killip class acute heart failure (29 and 7 %, р=0.01); mean hemoglobin concentration (125.6±27.9 and 141±16.6 g/l, р=0.003), prothrombin index (76.4±15.2 and 84.9±17.6 %, р=0.003), and left ventricular ejection fraction (47.7±6.1 and 50.7±7.2 %, р=0.02) were lower; and median concentrations of GDF-15 (1.95 [1.3; 2.8] and 1.45 [1.2; 2.0] ng/ml, р=0.03), NT-proBNP (947.3 [517.8; 1598.2], and 491.1 [85.1; 1069.1] pg/ml, р=0.006), and hs-CRP (14.1 [8.15; 36.75] and 7.8 [4.4; 16.2] mg/l, р=0.01) were higher. The presence of OD was associated with development of CVC, including urgent endpoints in the long-term and also increased the probability of fatal outcome within 6 months after discharge from the hospital. To predict the risk of CVC in patients with ACS and OD, two models with high prognostic values (AUC>0.9) were proposed. In the long-term, the value of NT-proBNP (cut-off point >524.5 pg/ml) was a statistically significant predictor for development of endpoints with a high predictive value (AUC>0.8).Conclusion The features of the clinical course of ACS in patients with OD indicate the importance of isolating such patients into a separate group. Additional use of the developed models, along with a standard risk assessment by the GRACE scale, will allow individualized management of patients with ACS and OD during the hospital and long-term (6 months) periods.
Gingival depigmentation with scalpel and diode laser
Authors: Khatri Ayush , Archi  , Priyanka  , Khatri Manish , Bansal Mansi , Rehan Md. 
Published: November 2021

Melanin, a nonhemoglobin-derived brown pigment, is the most common of the endogenous pigments and is produced by melanocytes present in the basal layer of the epithelium. Gingival hyperpigmentation is caused by excessive deposition of melanin located in the basal and suprabasal cell layers of the epithelium. Pigmentation of gingiva not just has an impact on esthetics but also creates psychological negativity. Though a wide range of techniques are available to manage this condition. Depigmentation procedures such as scalpel surgery, gingivectomy with free gingival autografting, electrosurgery, cryosurgery, chemical agents such as 90% phenol and 95% alcohol, abrasion with diamond bur, Nd: YAG laser, semiconductor diode laser, and CO laser have been employed for removal of melanin hyper pigmentation. The following case report describes two different surgical depigmentation techniques scalpel technique and lasers. Better results of depigmentation were achieved with diode laser than conventional scalpel with respect to esthetics and less postoperative discomfort.
THE LABORATORY STUDY OF RESIN-BONDED FIXED PARTIAL DENTURES IN THE POSTERIOR REGION (IN PREMOLAR-SIZED SPANS). PART 1
Authors: Petrikas Oleg , Tsigankov Kobstantin , Petrikas Inga 
Published: November 2021

Background. Developed at the end of the 20th century, resin-bonded fixed partial dentures are now a real alternative to traditional bridges and intraosseous implants. The mean survival rate of conventional fixed partial dentures clearly exceeds the mean survival rate of adhesive fixed partial dentures. Debonding of fixed/fixed resin-bonded fixed partial dentures is associated with the difference in the natural mobility of the abutment teeth. Therefore, the fixed/movable resin-bonded fixed partial dentures are preferable.
Objectives — to study the stress distribution in fixed/movable resin-bonded fixed partial dentures RBFPD using finite element analysis.
Methods. The finite element method was used to preliminary estimate the stress distribution pattern in fixed/movable resin-bonded fixed partial dentures (metal or fiberglass-composite). The calculation was carried out using special programs (Ansys 12.2 Inc. Ansys — USA and AWP 3 D Studio — Russia).
Results. The medial area of stresses is located only in the contact zone of the occlusal rest in the quantitative range of 32-60 N/mm2. The distal area of stresses corresponds to the distal connector, being approximately in the same range — 40-65 N/mm2. In the case of a metal retainer, the stresses also apply to it — 4-37 N/mm2. In the case of a fiber-composite retainer, stresses are practically not applied to it — 1-14 N/mm2.
Conclusions. Analysis of the stress distribution pattern for the fixed/movable resin-bonded fixed partial dentures, obtained by the finite element method, confirmed: 1) the expediency of shortening the minor retainer 2) the choice of a rigid metal (possibly ceramic) major retainer instead of a weakly rigid fiber-composite major retainer.
DEVELOPMENT AND IMPLEMENTATION OF COMPUTER-GENERATED SIMULATION PROGRAM FOR FORECASTING OF THE TEMPORARY DISABILITY DURATION IN CASE OF MAXILLOFACIAL REGION DISEASES AT DENTAL MEDICAL ORGANIZATIONS
Authors: Abdrashitova Alena , Saleev Rinat , Safina Roza , Saleev Nail 
Published: November 2021

Subject. digital technologies used by the service of examination of temporary disability associated with a dental disease and their adoption in dental medical organizations of the Republic of Tatarstan.
The aim — to develop a computer simulation program for predicting the duration of temporary disability associated with a dental disease.
Results. Odontogenic inflammatory processes, which were identified in 66.1% of the cases, represented the largest proportion of causes of temporary disability in patients of dental medical organizations. Maxillofacial traumas took the second place with a proportion of 13.9% of all the causes. Diseases related to loss of teeth due to extraction were identified in 384 patients, or in 7.4% of cases, and took the third place. The authors of the study determined the duration of temporary disability for each category of dental disease in the Republic of Tatarstan, the average duration of which was 8.48 ± 0.04 days. Based on clinical statistical analysis, a matrix was created for predicting the duration of dental diseases leading to temporary disability represented by a computer software for dental medical organizations.
Conclusions. Dental diseases in patients are related to the cases where treatment and rehabilitation are provided by several medical organizations; the authors created software for dentists, which predicts the duration of cases, their statistical analysis, eliminates errors in the issue of sick leave certificates, draws standard reporting statistical documents in order to provide reliable information on the state of the economically active population, to plan preventive activities, appropriate comprehensive treatment and rehabilitation of patients.
FEATURES OF DENTAL STATUS OF PATIENTS WITH SARS-COV-2
Authors: Nasibullina Alisa , Kabirova Milyausha , Kabirov Il'dar , Valishin Damir 
Published: November 2021

At the end of 2019, an outbreak of a new coronavirus infection occurred in the People's Republic of China with an epicenter in the city of Wuhan [26]. The causative agent was given the temporary name 2019-nCoV.
The World Health Organization officially named the infection-COVID-19 on February 11, 2020. The official name of the causative agent of infection SARS-CoV-2, was assigned by the international committee on the taxonomy of viruses [22]. A number of authors have established that the main role is played by receptors of angiotensin converting enzyme 2 (ACE2) in the penetration of the virus into target cells [19]. It is known that the transmission of SARS-CoV-2 occurs more often by airborne droplets during close contact with infected patients [15], as well as through direct contact with infected people and infected objects [17, 18, 20].
For healthcare professionals, SARS-CoV-2 has set tasks related to the rapid diagnosis and provision of medical care to patients. Currently, information on the clinical features, epidemiology, prevention and treatment of this disease is limited [13, 14].
To date, there is a limited amount of literature describing the dental status in patients diagnosed with SARS-CoV-2. Thus, the purpose of this study was to study the state of oral mucosa and substantiate its changes in patients with a laboratory-confirmed diagnosis of SARS-CoV-2 of mild to moderate severity, with or without concomitant oral coinfection.
On the other hand, knowledge of the peculiarities of the dental status of Sars-CoV-2 patients and timely rational treatment of diseases of the oral cavity should constitute an important stage in the algorithm for their specialized therapy [2].
The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment in patients with Sars-CoV-2. The conclusions are based on the results of a simple observational clinical study, in which a comparative assessment of dental status indicators was carried out in 40 patients with Sars-CoV-2 and 20 somatically healthy individuals of the same sex and age.
THE EFFECT OF COMPLEX TREATMENT WITH THE USE OF DENTAL GEL OF ORIGINAL COMPOSITION ON THE INDICATORS OF PSYCHO-EMOTIONAL AND DENTAL HEALTH OF CADETS OF THE DEPARTMENTAL INSTITUTE
Authors: Sitdikova Olesya , Kabirova Milyausha , Kudashkina Natalia , Sitdikov Favil 
Published: November 2021

Subject. Dental diseases are a frequent companion of distress, since the negative impact of psychoemotional stress on the immune status of cadets is reflected in changes in the microflora of the oral cavity and periodontal [4, 9].
The aim of the study is to evaluate the results of using the developed gel for the preven-tion and treatment of inflammatory periodontal diseases in cadets who are under psychoemotional stress.
Methodology. The group of examined persons consisted of 245 people-cadets of 1–4 courses of the Ministry of Internal Affairs of the Russian Federation. After the dental exami-nation, the cadets were divided into 2 groups: 26 cadets were found to have gingivi-tis/periodontitis of mild severity (group I), and 45 cadets without periodontal lesions (group II) served as a comparison group. The study included psychological testing, clarification of the state of their vegetative reactions and cortisol content in saliva, molecular genetic deter-mination of the composition of the most common periodontal pathogenic bacteria of the dentoalveolar furrow and enzyme immunoassay of the content of pro-inflammatory cytokines in saliva, cell-regulatory and immunosuppressive effects.
Results.The application of the gel helps to correct the phenomena of depression, while it affects the frequency of relapses of diseases.The effect of the application on the frequency of detection of periodontal pathogenic bacteria in cadets is manifested in relation to Tanerella forsythia and Aggregatibacter actinomycetemcomitans in the absence of depression, but in the presence of periodontal lesions. When the phenomena of gingivitis/periodontitis of mild se-verity occurred against the background of depression, the effects of using dental gel were in the form of a decrease in the occurrence of these bacteria. There was a significant drop in the oral fluid of IL-12 in the group with depression and periodontal disease, as well as IL-10 in the group without depression, but with mild gingivitis/periodontitis.
Conclusions. The developed dental gel is recommended both for the phenomena of de-pression and in cases of mild gingivitis/periodontitis against the background of psychoemotional stress.
FEATURES OF THE CLINICAL STATE OF PERIODONTAL TISSUES IN YOUNG PEOPLE
Authors: Usmanova Irina , Al-Qufaish M.A.M. , Kuznetsova Lilia , Shangareeva Alia , Kashina Sofia , Usmanov Irek , Tkachenko Elena , Osipenko Albina 
Published: November 2021

Relevance of the research topic. The authors found that various risk factors play a leading role in changing the clinical state of periodontal tissues. The aim is a comparative assessment of the clinical condition of periodontal tissues based on the correlation of hygienic and periodontal indices depending on age. Material and methods. A comprehensive clinical examination of 765 young people was conducted. The main group consisted of 70 (66.6%) patients with diagnosed chronic gingivitis and 145 (33.35%) patients with mild initial periodontitis due to the presence of conditionally pathogenic and periodontopathogenic types of microorganisms in the microbial biofilm. The control group was formed by 83 patients whose index evaluation revealed the condition of periodontal tissues in the form of clinically healthy gums with intact periodontal and clinically healthy gums with periodontal tissue loss, respectively, in 61.4 and 38.6% of cases of observations. Study results. In 61.4% of persons forming groups with clinically healthy gums, hygienic and periodontal indices are within normal values, in 38.6% of cases of persons there is a tendency to change them from the norm. In 47.7% and 52.3% of cases of individuals with gingivitis and in 48.3% and 51.7% of individuals with initial periodontitis, the OHI-S index correlates with the indicators of PMA, GI and SBI (p < 0.001, p = 0.315).
Conclusions. Thus, the revealed changes in the indicators of hygienic and periodontal indices (the Chuprov conjugacy coefficient is 0.64 (p = 0.012), the Kraskel-Wallis criterion (H = 7.89, p < 0.05) makes it possible to clearly determine the clinical condition of periodontal tissues corresponding to modern European criteria.
EFFICIENCY OF COMBINATIONS OF ORAL HYGIENE PRODUCTS IN CHILDREN AT DIFFERENT LEVEL OF ANTHROPOGENIC LOAD
Authors: Samatova Ravilya , Safina Roza , Ahmetova Guzel 
Published: November 2021

Prevention of dental caries in children occupies one of the first places in pediatric dentistry. Indeed, during the period of tertiary mineralization of the enamel, it is necessary to pay special attention to the mineralization of the enamel of the teeth. The most urgent issue is the prevention of dental caries at this time. Correctly selected basic and additional oral hygiene products have a preventive effect. Dental caries has a multifactorial etiology. It can be a genetic factor, eating of carbohydrate foods and sugars in large amounts , poor oral hygiene,ecology and others. It has been proven that the technogenic load of the environment negatively affects the dental health of children. The children are most sensitive to environmental influences. The purpose of this work was to determine the most effective preventive action of the selected combinations of oral hygiene products for children of primary school age who were born and live in areas under different anthropogenic loads.
Methodology. Various combinations of basic and additional oral hygiene products for primary school children, containing fluorine and amorphous nanohydroxyapatite, have been proposed. Studied: enamel caries resistance, oral fluid pH, oral fluid microcrystallization, tooth electrical conductivity, etc. According to the results of the study, the most effective combinations of oral hygiene products were selected for dental caries prevention of the primary school children who were born and live at different levels of anthropogenic load. The children and their parents were trained in the correct methodology for oral care and proper nutrition.
TAʿLĪM AL-LUĠAH AL-ʿARABIYYAH FĪ AL-MAʿĀHID AL-ISLĀMIYYAH FĪ INDŪNĪSIYYĀ
Authors: Sa'adah Noor 
Published: November 2021

This study aims to describe the academic material in Arabic teaching in the salaf and the modern Institutions, and describe the similarities and differences of Arabic teaching in both of them.The study used a qualitative. In this study the data were collected by using interviews, observation, and documentation. To analyze the data, the researcher used the interactive technique of Miles and Huberman, while to test the validity of the data, the method of triangulation technique was used.The result of the study shows the following: (1) The Arabic teaching materials in Rasyidiyah Khalidiyah Islamic boarding schools consist of 10 subjects, while in the Raudhatut Thalibin only consist of 5 subjects. The Rasyidiyah Khalidiyah boarding schools use theory of integrated and separated system in their Arabic teaching materials, while the Raudhatut Thalibin use separated system theory; (2) The instructional method engaged in Arabic teaching is the eclectic method. The teaching use concrete (indrawi) media. Both oral and written test were applied in the evaluation system; (3) The kinds of language environment applied in Arabic teaching in Rasyidiyah Kalidiyah Islamic boarding school consist of the environment of listening and reading. While speaking, reading and listening environments, were applied in Raudhatut Thalibin Islamic boarding school.Keywor