bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atmospheric Carbon and Transport – America (ACT‐America) Data Sets: Description, Management, and Delivery
Authors: Wei Y. , Shrestha R. , Pal S. , Gerken T. , Feng S. , McNelis J. , Singh D. , Thornton M. M. , Boyer A. G. , Shook M. A. , Chen G. , Baier B. C. , Barkley Z. R. , Barrick J. D. , Bennett J. R. , Browell E. V. , Campbell J. F. , Campbell L. J. , Choi Y. , Collins J. , Dobler J. , Eckl M. , Fiehn A. , Fried A. , Digangi J. P. , Barton‐Grimley R. , Halliday H. , Klausner T. , Kooi S. , Kostinek J. , Lauvaux T. , Lin B. , McGill M. J. , Meadows B. , Miles N. L. , Nehrir A. R. , Nowak J. B. , Obland M. , O’Dell C. , Fao R. M. P. , Richardson S. J. , Richter D. , Roiger A. , Sweeney C. , Walega J. , Weibring P. , Williams C. A. , Yang M. M. , Zhou Y. , Davis K. J. 
Published: June 2021

AbstractThe ACT‐America project is a NASA Earth Venture Suborbital‐2 mission designed to study the transport and fluxes of greenhouse gases. The open and freely available ACT‐America data sets provide airborne in situ measurements of atmospheric carbon dioxide, methane, trace gases, aerosols, clouds, and meteorological properties, airborne remote sensing measurements of aerosol backscatter, atmospheric boundary layer height and columnar content of atmospheric carbon dioxide, tower‐based measurements, and modeled atmospheric mole fractions and regional carbon fluxes of greenhouse gases over the Central and Eastern United States. We conducted 121 research flights during five campaigns in four seasons during 2016–2019 over three regions of the US (Mid‐Atlantic, Midwest and South) using two NASA research aircraft (B‐200 and C‐130). We performed three flight patterns (fair weather, frontal crossings, and OCO‐2 underflights) and collected more than 1,140 h of airborne measurements via level‐leg flights in the atmospheric boundary layer, lower, and upper free troposphere and vertical profiles spanning these altitudes. We also merged various airborne in situ measurements onto a common standard sampling interval, which brings coherence to the data, creates geolocated data products, and makes it much easier for the users to perform holistic analysis of the ACT‐America data products. Here, we report on detailed information of data sets collected, the workflow for data sets including storage and processing of the quality controlled and quality assured harmonized observations, and their archival and formatting for users. Finally, we provide some important information on the dissemination of data products including metadata and highlights of applications of ACT‐America data sets.
CMIP5 Intermodel Relationships in the Baseline Southern Ocean Climate System and With Future Projections
Authors: Kajtar Jules B. , Santoso Agus , Collins Matthew , Taschetto Andréa S. , England Matthew H. , Frankcombe Leela M. 
Published: June 2021

AbstractClimate models exhibit a broad range in the simulated properties of the climate system. In the early historical period, the absolute global mean surface air temperature in Coupled Model Intercomparison Project, Phase 5 (CMIP5) models spans a range of ∼12°C – 15°C. Other climate variables may be linked to global mean temperature, and so accurate representation of the baseline climate state is crucial for meaningful future climate projections. In CMIP5 baseline climate states, statistically significant intermodel correlations between Southern Ocean surface temperature, outgoing shortwave radiation, cloudiness, the position of the mid‐latitude eddy‐driven jet, and Antarctic sea ice area are found. The baseline temperature relationships extend to projected future changes in the same set of variables, impacting on the projected global mean surface temperature change. Models with initially cooler Southern Ocean tend to exhibit more global warming, and vice versa for initially warmer models. These relationships arise due to a “capacity for change”. For example, cold‐biased models tend to have more cloud cover, sea ice, and equatorward jet initially, and thus a greater capacity to lose cloud cover and sea ice, and for the jet to shift poleward under global warming. A first look at emerging data from CMIP6 reveals a shift of the relationship from the Southern Ocean towards the Antarctic region, possibly due to reductions in Southern Ocean biases, such as in westerly wind representation.
Mendelian randomisation for psychiatry: how does it work, and what can it tell us?
Authors: Wootton Robyn E. , Jones Hannah J. , Sallis Hannah M. 
Published: June 2021

AbstractThe successful prevention of mental illness relies upon the identification of causal, modifiable risk factors. However, observational evidence exploring such risk factors often produces contradictory results and randomised control trials are often expensive, time-consuming or unethical to conduct. Mendelian randomisation (MR) is a complementary approach that uses naturally occurring genetic variation to identify possible causal effects between a risk factor and an outcome in a time-efficient and low-cost manner. MR utilises genetic variants as instrumental variables for the risk factor of interest. MR studies are becoming more frequent in the field of psychiatry, warranting a reflection upon both the possibilities and the pitfalls. In this Perspective, we consider several limitations of the MR method that are of particular relevance to psychiatry. We also present new MR methods that have exciting applications to questions of mental illness. While we believe that MR can make an important contribution to the field of psychiatry, we also wish to emphasise the importance of clear causal questions, thorough sensitivity analyses, and triangulation with other forms of evidence.
Classification challenges of the 2019 revised International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
Authors: Kirshblum Steven , Schmidt Read Mary , Rupp Rüdiger 
Published: June 2021

Abstract
Study design
Retrospective review of ISNCSCI datasets.

Objectives
To discuss the correct classification of ISNCSCI datasets considered as challenging.

Setting
International expert collaboration.

Methods
The International Standards Committee of the American Spinal Injury Association (ASIA) receives challenging case scenarios regarding the International Standards for the Neurological Classification of Spinal Cord Injury (ISNCSCI). Among those cases received, sample cases representing different categories of typical classification difficulties were identified by members of the International Standards committee.

Results
From the cases received, five sample cases were identified as representative for publication. These cases are related to the correct classification in the presence of non-SCI related conditions, the determination of motor zones of partial preservation in regions with no myotomes to test, the classification of the ASIA Impairment Scale in patients with substantial motor function below the motor level but no sacral sparing, the inclusion of non-key muscle functions in the classification of sensory incomplete individuals, and the correct classification of individuals with an amputation.

Conclusion
Presenting cases with challenging classifications, along with responses and explanations, will serve spinal cord injury professionals to better understand and utilize the ISNCSCI classification. As the ISNCSCI endorsed by ASIA and the International Spinal Cord Society (ISCoS) evolves over time, such resources are important to clarify inquiries from the spinal cord injury community and to understand the rationale for revisions.
Beach sand oil spills select for generalist microbial populations
Authors: Heritier-Robbins Patrick , Karthikeyan Smruthi , Hatt Janet K , Kim Minjae , Huettel Markus , Kostka Joel E , Konstantinidis Konstantinos T , Rodriguez-R Luis M 
Published: June 2021

Abstract
The specialization-disturbance hypothesis predicts that, in the event of a disturbance, generalists are favored, while specialists are selected against. This hypothesis has not been rigorously tested in microbial systems and it remains unclear to what extent it could explain microbial community succession patterns following perturbations. Previous field observations of Pensacola Beach sands that were impacted by the Deepwater Horizon (DWH) oil spill provided evidence in support of the specialization-disturbance hypothesis. However, ecological drift as well as uncounted environmental fluctuations (e.g., storms) could not be ruled out as confounding factors driving these field results. In this study, the specialization-disturbance hypothesis was tested on beach sands, disturbed by DWH crude oil, ex situ in closed laboratory advective-flow chambers that mimic in situ conditions in saturated beach sediments. The chambers were inoculated with weathered DWH oil and unamended chambers served as controls. The time series of shotgun metagenomic and 16S rRNA gene amplicon sequence data from a two-month long incubation showed that functional diversity significantly increased while taxonomic diversity significantly declined, indicating a decrease in specialist taxa. Thus, results from this laboratory study corroborate field observations, providing verification that the specialization-disturbance hypothesis can explain microbial succession patterns in crude oil impacted beach sands.
Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms
Authors: Haan Niels , Westacott Laura J. , Carter Jenny , Owen Michael J. , Gray William P. , Hall Jeremy , Wilkinson Lawrence S. 
Published: June 2021

AbstractGenetic risk factors can significantly increase chances of developing psychiatric disorders, but the underlying biological processes through which this risk is effected remain largely unknown. Here we show that haploinsufficiency of Cyfip1, a candidate risk gene present in the pathogenic 15q11.2(BP1–BP2) deletion may impact on psychopathology via abnormalities in cell survival and migration of newborn neurons during postnatal hippocampal neurogenesis. We demonstrate that haploinsufficiency of Cyfip1 leads to increased numbers of adult-born hippocampal neurons due to reduced apoptosis, without altering proliferation. We show this is due to a cell autonomous failure of microglia to induce apoptosis through the secretion of the appropriate factors, a previously undescribed mechanism. Furthermore, we show an abnormal migration of adult-born neurons due to altered Arp2/3 mediated actin dynamics. Together, our findings throw new light on how the genetic risk candidate Cyfip1 may influence the hippocampus, a brain region with strong evidence for involvement in psychopathology.
Allogeneic stem cell transplantation for AML patients with RUNX1 mutation in first complete remission: a study on behalf of the acute leukemia working party of the EBMT
Authors: Waidhauser Johanna , Labopin Myriam , Esteve Jordi , Kröger Nicolaus , Cornelissen Jan , Gedde-Dahl Tobias , Van Gorkom Gwendolyn , Finke Jürgen , Rovira Montserrat , Schaap Nicolaas , Petersen Eefke , Beelen Dietrich , Bunjes Donald , Savani Bipin , Schmid Christoph , Nagler Arnon , Mohty Mohamad ,   on behalf of the Acute Leukemia Working Party of EBMT
Published: June 2021

AbstractAcute myeloid leukemia with runt-related transcription factor 1 gene mutation (RUNX1+ AML) is associated with inferior response rates and outcome after conventional chemotherapy. We performed a retrospective, registry-based analysis to elucidate the prognostic value of RUNX1 mutation after allogeneic stem cell transplantation (alloSCT). All consecutive adults undergoing alloSCT for AML in first complete remission (CR1) between 2013 and 2019 with complete information on conventional cytogenetics and RUNX1 mutational status were included. Endpoints of interest were cumulative relapse incidence, non-relapse mortality, overall and leukemia-free survival (OS/LFS), and GvHD-free/relapse-free survival. A total of 674 patients (183 RUNX1+, 491 RUNX1−) were identified, with >85% presenting as de novo AML. Median follow-up was 16.4 (RUNX1+) and 21.9 (RUNX1−) months. Survival rates showed no difference between RUNX1+ and RUNX1− patients either in univariate or multivariate analysis (2-year OS: 67.7 vs. 66.1%, p = 0.7; 2-year LFS: 61.1 vs. 60.8%, p = 0.62). Multivariate analysis identified age, donor type and poor cytogenetics as risk factors for inferior outcome. Among patients with RUNX+ AML, older age, reduced intensity conditioning and minimal residual disease at alloSCT predicted inferior outcome. Our data provide evidence that the negative influence of RUNX1 mutations in patients with AML can be overcome by transplantation in CR1.
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM)
Authors: Lapidot Moshe , Case Abigail E. , Weisberg Ellen L. , Meng Chengcheng , Walker Sarah R. , Garg Swati , Ni Wei , Podar Klaus , Hung Yin P. , Carrasco Ruben D. , Knott Aine , Gokhale Prafulla C. , Sharma Sunil , Pozhitkov Alex , Kulkarni Prakash , Frank David A. , Salgia Ravi , Griffin James D. , Saladi Srinivas V. , Bueno Raphael , Sattler Martin 
Published: June 2021

AbstractBackgroundMalignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A (lysine-specific histone demethylase 4) was overexpressed in MPM.MethodsKDM4A protein expression was determined by immunohistochemistry or immunoblotting. Functional inhibition of KDM4A by targeted knockdown and small molecule drugs was correlated to cell growth using cell lines and a xenograft mouse model. Gene expression profiling was performed to identify KDM4A-dependent signature pathways.ResultsLevels of KDM4A were found to be significantly elevated in MPM patients compared to normal mesothelial tissue. Inhibiting the enzyme activity efficiently reduced cell growth in vitro and reduced tumour growth in vivo. KDM4A inhibitor-induced apoptosis was further enhanced by the BH3 mimetic navitoclax. KDM4A expression was associated with pathways involved in cell growth and DNA repair. Interestingly, inhibitors of the DNA damage and replication checkpoint regulators CHK1 (prexasertib) and WEE1 (adavosertib) within the DNA double-strand break repair pathway, cooperated in the inhibition of cell growth.ConclusionsThe results establish a novel and essential role for KDM4A in growth in preclinical models of MPM and identify potential therapeutic approaches to target KDM4A-dependent vulnerabilities.
Mixed methods process evaluation of my breathing matters, a digital intervention to support self-management of asthma
Authors: Greenwell Kate , Ainsworth Ben , Bruton Anne , Murray Elizabeth , Russell Daniel , Thomas Mike , Yardley Lucy 
Published: June 2021

AbstractThis study aimed to explore user engagement with ‘My Breathing Matters’, a digital self-management intervention for asthma, and identify factors that may influence engagement. In a mixed methods design, adults with asthma allocated to the intervention arm of a feasibility trial (n = 44) participated in semi-structured interviews (n = 18) and a satisfaction questionnaire (n = 36) to explore their views and experiences of the intervention. Usage data highlighted that key intervention content was delivered to most users. The majority of questionnaire respondents (78%;n = 28) reported they would recommend the intervention to friends and family. Interviewees expressed positive views of the intervention and experienced several benefits, mainly improved asthma control, medication use, and breathing technique. Factors that may influence user engagement were identified, including perceptions of asthma control, current self-management practices, and appeal of the target behaviours and behaviour change techniques. Findings suggested My Breathing Matters was acceptable and engaging to participants, and it was used as intended.
An early Devonian flora from the Baviaanskloof Formation (Table Mountain Group) of South Africa
Authors: Gess Robert W. , Prestianni Cyrille 
Published: June 2021

AbstractNewly discovered early plant bearing lenses from the Baviaanskloof Formation at Impofu Dam in the Eastern Cape Province of South Africa provide evidence for one of the most diverse Late Silurian to Early Devonian assemblages known to date. This work represents the first account of this flora. Fifteen taxa are presented, including eleven diagnosed to existing genera, of which eight may be reasonably diagnosed to existing species including several species of the genus Cooksonia. Three new taxa, Krommia parvapila, Elandia itshoba and Mtshaelo kougaensis are described. This flora is furthermore remarkable for the large number of complete or sub-complete specimens allowing good understanding of earliest plant architecture. The assemblage bears the greatest resemblance to Early Lochkovian assemblages from the Parana Basin of Brazil and the Anglo Welsh basin. Biostratigraphic constraints on the dating of the Baviaanskloof Formation are provided by this flora, which represents the oldest known from Africa.
Disorganization of intercalated discs in dilated cardiomyopathy
Authors: Ito Yukinobu , Yoshida Makoto , Masuda Hirotake , Maeda Daichi , Kudo-Asabe Yukitsugu , Umakoshi Michinobu , Nanjo Hiroshi , Goto Akiteru 
Published: June 2021

AbstractDilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and other cardiac diseases must be ruled out. Several studies have reported pathological findings that are characteristic of DCM, including cardiomyocyte atrophy, nuclear pleomorphism, and interstitial fibrosis, but none of these findings are DCM-specific. In this study, we examined the morphological differences in the intercalated discs (ICDs) between three groups of patients, a DCM group, a chronic heart failure group, and a control group. A total of 22 autopsy cases, including five DCM cases, nine CHF cases and eight control cases, were retrieved from the archives of the Department of Pathology at Akita University, Japan. The morphological differences were examined using multiple methods: macroscopic examination, light microscopy, immunohistochemistry, electron microscopy, and gene expression analyses. We observed disorganized ICDs, clearly illustrated by N-cadherin immunostaining in the DCM group. “Reduction of N-cadherin immunostaining intensity” and “ICD scattering” was DCM-specific. The results suggest that disorganized ICDs contribute to the development of DCM, and that N-cadherin immunostaining is useful for determining the presence of disorganized ICDs and for the pathological diagnosis of DCM.
Tripartite entropic uncertainty relation under phase decoherence
Authors: Abdelghany R. A. , Mohamed A.-B. A. , Tammam M. , Kuo Watson , Eleuch H. 
Published: June 2021

AbstractWe formulate the tripartite entropic uncertainty relation and predict its lower bound in a three-qubit Heisenberg XXZ spin chain when measuring an arbitrary pair of incompatible observables on one qubit while the other two are served as quantum memories. Our study reveals that the entanglement between the nearest neighbors plays an important role in reducing the uncertainty in measurement outcomes. In addition we have shown that the Dolatkhah’s lower bound (Phys Rev A 102(5):052227, 2020) is tighter than that of Ming (Phys Rev A 102(01):012206, 2020) and their dynamics under phase decoherence depends on the choice of the observable pair. In the absence of phase decoherence, Ming’s lower bound is time-invariant regardless the chosen observable pair, while Dolatkhah’s lower bound is perfectly identical with the tripartite uncertainty with a specific choice of pair.
Phlogopite-pargasite coexistence in an oxygen reduced spinel-peridotite ambient
Authors: Bonadiman Costanza , Brombin Valentina , Andreozzi Giovanni B. , Benna Piera , Coltorti Massimo , Curetti Nadia , Faccini Barbara , Merli Marcello , Pelorosso Beatrice , Stagno Vincenzo , Tesauro Magdala , Pavese Alessandro 
Published: June 2021

AbstractThe occurrence of phlogopite and amphibole in mantle ultramafic rocks is widely accepted as the modal effect of metasomatism in the upper mantle. However, their simultaneous formation during metasomatic events and the related sub-solidus equilibrium with the peridotite has not been extensively studied. In this work, we discuss the geochemical conditions at which the pargasite-phlogopite assemblage becomes stable, through the investigation of two mantle xenoliths from Mount Leura (Victoria State, Australia) that bear phlogopite and the phlogopite + amphibole (pargasite) pair disseminated in a harzburgite matrix. Combining a mineralogical study and thermodynamic modelling, we predict that the P–T locus of the equilibrium reaction pargasite + forsterite = Na-phlogopite + 2 diopside + spinel, over the range 1.3–3.0 GPa/540–1500 K, yields a negative Clapeyron slope of -0.003 GPa K–1 (on average). The intersection of the P–T locus of supposed equilibrium with the new mantle geotherm calculated in this work allowed us to state that the Mount Leura xenoliths achieved equilibrium at 2.3 GPa /1190 K, that represents a plausible depth of ~ 70 km. Metasomatic K-Na-OH rich fluids stabilize hydrous phases. This has been modelled by the following equilibrium equation: 2 (K,Na)-phlogopite + forsterite = 7/2 enstatite + spinel + fluid (components: Na2O,K2O,H2O). Using quantum-mechanics, semi-empirical potentials, lattice dynamics and observed thermo-elastic data, we concluded that K-Na-OH rich fluids are not effective metasomatic agents to convey alkali species across the upper mantle, as the fluids are highly reactive with the ultramafic system and favour the rapid formation of phlogopite and amphibole. In addition, oxygen fugacity estimates of the Mount Leura mantle xenoliths [Δ(FMQ) = –1.97 ± 0.35; –1.83 ± 0.36] indicate a more reducing mantle environment than what is expected from the occurrence of phlogopite and amphibole in spinel-bearing peridotites. This is accounted for by our model of full molecular dissociation of the fluid and incorporation of the O-H-K-Na species into (OH)-K-Na-bearing mineral phases (phlogopite and amphibole), that leads to a peridotite metasomatized ambient characterized by reduced oxygen fugacity.
Hemorrhagic stroke treated by transcranial neuroendoscopic approach
Authors: Cai Qiang , Li Zhiyang , Wang Wenju , Ji Baowei , Liu Junhui , Chen Zhibiao , Chen Qianxue , Mao Shanping 
Published: June 2021

AbstractHemorrhagic stroke (HS) is usually treated under microscopy, but recently, an increasing number of cases have been treated under neuroendoscopy. The objective of this study was to explore the feasibility and efficacy of a transcranial neuroendoscopic approach for HS. Based on etiology and clinical features, 203 HS patients were classified into two groups, with 100 patients in the primary HS (PHS) group and 103 patients in the secondary HS (SHS) group. All patients were treated either by full neuroendoscopy (FNE) or by neuroendoscopy combined with microsurgery (ECM). Outcomes were assessed according to the Glasgow Coma Scale (GCS) at discharge, and the rate of good plus excellent results was recorded as the GE rate to assess the treatment effect. All 203 patients underwent surgery successfully, with 165 patients who underwent FNE and 38 patients who underwent ECM. No patients died within 3 days after surgery, and the surgery-related mortality rate was 0%, but a total of 4 patients died by discharge, and the overall mortality rate was 1.97%. A total of 133 patients showed an excellent result and 16 showed a good result, for a total GE rate of 73%. Neuroendoscopy can provide excellent illumination, clear visualization, and multiangle views in HS. The transcranial neuroendoscopic approach is feasible and safe for both PHS and SHS and is very effective for hematoma evacuation. However, some aneurysms and most arteriovenous malformations and arteriovenous fistulas require ECM.