bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Sequence of Intracranial Radiotherapy and Systemic Treatment With Tyrosine Kinase Inhibitors for Gene-Driven Non-Small Cell Lung Cancer Brain Metastases in the Targeted Treatment Era: A 10-Year Single-Center Experience
Authors: Yang Siran , Xiao Jianping , Liu Qingfeng , Zhang Ye , Bi Nan , Huang Xiaodong , Chen Xuesong , Wang Kai , Ma Yuchao , Deng Lei , Wang Wenqing , Zhao Ruizhi , Li Junling , Yi Junlin , Wang Shulian , Li Yexiong 
Published: October 2021

PurposeThe high intracranial efficacy of targeted therapeutic agents poses a challenge in determining the optimal sequence of local radiation therapy (RT) and systemic treatment with tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) patients with brain metastasis (BM). Therefore, we conducted a cohort study to elucidate the appropriate treatment strategy, either upfront RT or deferred RT including a toxicity assessment, in these patients.Patients and MethodsWe retrospectively evaluated patients with gene-driven BMs from a single institution and divided them into deferred and upfront RT groups. Survival was estimated using a log-rank test. Intracranial progression was estimated using Fine-Gray competing risks model. Cox proportional hazards regression was performed for multivariable analysis in the entire group and subgroups.ResultsAmong the 198 eligible patients, 94 and 104 patients received deferred and upfront RT, respectively. The upfront RT group showed a lower intracranial progression risk with an adjusted sub-distribution hazard ratios of 0.41 (95% CI, 0.30–0.57) than did the deferred RT group (median intracranial progression-free survival [iPFS], 19.9 months vs. 11.1 months; p &lt; 0.001). The median overall survival (OS; 43.2 months vs. 49.1 months, p = 0.377) and BM-specific survival (92.1 months vs. 82.9 months, p = 0.810) after salvage therapy were not significantly different between the upfront and deferred groups. Among patients with progressed extracranial disease, the deferred RT group showed significantly better OS than did the upfront RT group (44.0 vs. 28.1 months, p = 0.022). Grade 3–4 treatment-related adverse events were rare, and similar toxicities were observed between the two groups.ConclusionCompared to the deferred RT group, the upfront RT group achieved longer iPFS and similar survival outcomes in most patients with gene-driven NSCLC BM, although patients with progression of extracranial disease might benefit from deferred RT. Both groups showed well-tolerated toxicities.Trial registration IDNCT04832672.
Visual and Verbal Working Memory and Processing Speed Across the Adult Lifespan: The Effect of Age, Sex, Educational Level, Awakeness, and Hearing Sensitivity
Authors: Kestens Katrien , Degeest Sofie , Miatton Marijke , Keppler Hannah 
Published: October 2021

Objective: To strengthen future methodological choices regarding the measurement of cognition within the field of audiology, the current study aimed to examine the effect of, among other things, hearing sensitivity on the backward corsi tapping task (i.e., visual working memory and processing speed) and the letter-number sequencing task (i.e., verbal working memory and processing speed).Design and Study Sample: The backward corsi tapping task and the letter-number sequencing task were administered to 184 participants, aged between 18 and 69 years. The effect of age, sex, educational level, awakeness, and hearing sensitivity on verbal and visual working memory and processing speed was assessed using stepwise multiple regression analyses.Results: For all outcome variables, a decrease in performance was observed with increasing age. For visual and verbal working memory, males outperformed females, whereas no clear sex effect was observed for visual and verbal processing speed. Hearing sensitivity had only a significant impact on visual processing speed.Conclusion: The importance to evaluate cognitive construct validity within audiological research was highlighted. Further research should focus on investigating the associations between speech understanding on the one hand and the backward corsi tapping task and letter-number sequencing task on the other hand.
Prediction of Obstetric Patient Flow and Horizontal Allocation of Medical Resources Based on Time Series Analysis
Authors: Li Hua , Mu Dongmei , Wang Ping , Li Yin , Wang Dongxuan 
Published: October 2021

Objective: Given the ever-changing flow of obstetric patients in the hospital, how the government and hospital management plan and allocate medical resources has become an important problem that needs to be urgently solved. In this study a prediction method for calculating the monthly and daily flow of patients based on time series is proposed to provide decision support for government and hospital management.Methods: The historical patient flow data from the Department of Obstetrics and Gynecology of the First Hospital of Jilin University, China, from January 1, 2018, to February 29, 2020, were used as the training set. Seven models such as XGBoost, SVM, RF, and NNAR were used to predict the daily patient flow in the next 14 days. The HoltWinters model is then used to predict the monthly flow of patients over the next year.Results: The results of this analysis and prediction model showed that the obstetric inpatient flow was not a purely random process, and that patient flow was not only accompanied by the random patient flow but also showed a trend change and seasonal change rule. ACF,PACF,Ljung_box, and residual histogram were then used to verify the accuracy of the prediction model, and the results show that the Holtwiners model was optimal. R2, MAPE, and other indicators were used to measure the accuracy of the 14 day prediction model, and the results showed that HoltWinters and STL prediction models achieved high accuracy.Conclusion: In this paper, the time series model was used to analyze the trend and seasonal changes of obstetric patient flow and predict the patient flow in the next 14 days and 12 months. On this basis, combined with the trend and seasonal changes of obstetric patient flow, a more reasonable and fair horizontal allocation scheme of medical resources is proposed, combined with the prediction of patient flow.
Addressing Climate Internal Variability on Future Intensity-Duration-Frequency Curves at Fine Scales across South Korea
Authors: Doi Manh Van , Kim Jongho 
Published: October 2021

Designing water infrastructure requires information about the magnitude and frequency of upcoming rainfall. A limited range of data offers just one of many realizations that occurred in the past or will occur in the future; thus, it cannot sufficiently explain climate internal variability (CIV). In this study, future relationships among rainfall intensity (RI), duration, and frequency (called the IDF curve) are established by addressing the CIV and tail characteristics with respect to frequency. Specifically, 100 ensembles of 30-year time series data were created to quantify that uncertainty. Then, the tail characteristics of future extreme rainfall events were investigated to determine whether they will remain similar to those in the present. From the RIs computed for control and future periods under two emission scenarios, following are the key results. Firstly, future RI will increase significantly for most locations, especially near the end of this century. Secondly, the spatial distributions and patterns indicate higher RI in coastal areas and lower RI for the central inland areas of South Korea, and those distributions are similar to those of the climatological mean (CM) and CIV. Thirdly, a straightforward way to reveal whether the tail characteristics of future extreme rainfall events are the same as those in the present is to inspect the slope value for the factor of change (FOC), mFOC. Fourthly, regionalizing with nearby values is very risky when investigating future changes in precipitation frequency estimates. Fifthly, the magnitude of uncertainty is large when the data length is short and gradually decreases as the data length increases for all return periods, but the uncertainty range becomes much greater as the return period becomes large. Lastly, inferring future changes in RI from the CM is feasible only for small return periods and at locations where mFOC is close to zero.
PENGARUH KEPUASAN KERJA TERHADAP KINERJA KARYAWAN DI PEGADAIAN CABANG PEGADAIAN SYARIAH BANGKALAN
Authors: Kholid M. , Muttaqin Imamul , Nurhayati Uzie 
Published: October 2021

Penelitian ini ingin menguji dan mengetahui seberapa besar pengaruh kepuasan kerja (X) dan terhadap kinerja karyawan (Y) dimana populasinya adalah sebagian karyawan Pegadaian Syariah Cabang Bangkalan dan dalam penelitian ini sejumlah 32 karyawan. Teknik pengambilan sampel dalam penelitian ini adalah teknik sampling jenuh, yaitu teknik sampling yang tidak memberikan peluang bagi seluruh anggota populasi dimana penetuan sampel pada sebagian anggota populasi. Metode pengumpulan data dilakukan dengan angket atau kuesioner. Teknik Analisis yang digunakan adalah uji statistik melalui uji T, koefisien determinasi (R2) dan regresi linier sederhana. Berdasarkan hasil penelitian dengan Uji T menunjukkan bahwa variabel kepuasan kerja mempunyai pengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai t-hitung lebih besar dari pada t-tabel (2.063 ? 1,694) dan nilai signifikan lebih kecil dari 0.05 (0.0478 ? 0.05). Sedangkan hasil koefisien determinasi (R2) sebesar 0.124 ini berati kontribusi variabel independen (kepuasan kerja) mempengaruhi variabel dependen (kinerja karyawan) sebesar 1,24% sedangkan sisanya sebesar 98.76% dipengaruhi oleh variabel lain diluar model penelitian.
This study examines how the influence of job satisfaction (X) and on the performance of employees (Y) Pawnshop Syariah, Bangkalan Branch. The total population in this study were 32 employees. The sampling technique used is a saturated sampling technique, which is a sampling technique that does not provide opportunities for all members of the population. So, the determination of the sample on some members of the research population. The method of data collection is done with a questionnaire or questionnaire. The analysis technique used is statistical test through T test, coefficient of determination (R2) and simple linear regression. Based on the results of the research with the T test, it shows that the job satisfaction variable has a positive and significant effect on employee performance with a t-count value greater than t-table (2.063 ? 1.694) and a significant value less than 0.05 (0.0478 ? 0.05). While the results of the coefficient of determination (R2) of 0.124 means that the contribution of the independent variable (job satisfaction) affects the dependent variable (employee performance) by 1.24% while the remaining 98.76% is influenced by other variables outside the research model.
Ethical Considerations for Community Based Psychosocial Accompaniment: Towards a Strengthened Mental Health Response amidst Covid-19 Pandemic
Authors: Musili Telesia Kathini , Cheronoh Fancy 
Published: October 2021

The outbreak of the Covid-19 pandemic in the early months of 2020 thwarted and continues to disrupt the strides made in the provision of health services including mental health. Mental health stability is vital to personal wellbeing, the building of relationships and the making of notable contributions to society. This paper sought to situate the importance of psychosocial accompaniment within the community as one of the strategies of responding to mental health challenges that are usually compounded by stigma and discrimination. Content analysis of relational actions prompted by the infectious Covid-19 pandemic formed the basis of this article. Ethical considerations of justice and mutual trust are advanced as foundational values in a community of relations that can easily and practically respond to mental health instability amidst contagious epidemics. The study employed reported experiences of distress emanating from life disruptions that significantly led to poorer mental health in order to urge for psychosocial accompaniment that is founded within the community level. Close relations within the community are lauded as a practical strategy of enhancing and strengthening mental health response amidst contagious pandemics, such as Covid-19.
Assessment of Degree of Dental Awareness in Schoolchildren Aged 10–15 Years in Bilaspur District, Chhattisgarh
Authors: Agrawal Ruchi , Shrivastava Swatantra , Reche Amit , Wasnik Milind T. , Sangha Kuldip Singh , Patil Santosh R. 
Published: October 2021

Introduction:
Oral health may be defined as a standard of health of the oral and related tissues which enables an individual to eat, speak, and socialize without active disease, discomfort, or embarrassment and which contributes to general wellbeing.

Aim:
This study aimed to evaluate the level of oral awareness among schoolchildren aged 10–15 years in Bilaspur district, Chhattisgarh.

Materials and Methods:
In an epidemiological cross-sectional survey, 10–15 years old schoolchildren in Bilaspur were examined to assess the dental awareness. A survey form was prepared with help of a self-administered structured questionnaire written in Hindi. The trained dental surgeon distributed questionnaire among the children. A completely answered questionnaire was collected. The observations were reviewed and analyzed.

Results:
Among the total number of participants (879), 98.1% of them use toothbrush to clean their teeth, 64.7% did not use dental floss, 91.5% of participants clean their tongue, 59.7% of children use mouthwash, and 85.7% rinse their mouth after every meal.

Conclusion:
The result of the present study suggests that the oral hygiene habits, oral health awareness, and knowledge level among schoolchildren are poor and need to be improved.
Utilization Pattern of Dental Care and Dental Caries Prevalence Among Children Aged 12- and 15-Year in Himachal Pradesh, India
Authors: Bhatt Sumeet 
Published: October 2021

Background:
Regular dental visits are associated with better oral health outcomes in children. In India, data on the utilization of dental services among children are insufficient.

Aim:
The aim of this study was to find the prevalence of dental services use among 12- and 15-year-old school children and to assess if there is an association between utilization pattern and dental caries prevalence.

Materials and Methods:
A cross-sectional survey was conducted among ten randomly selected government senior secondary schools in Paonta Sahib Education Block. A total of 1120 children aged 12- and 15-year were included in the study. The children were examined for the presence of untreated dental caries as per the guidelines of the World Health Organization. The information on dental visiting pattern was obtained from the parents using a structured questionnaire. Descriptive statistics and Chi-square test were used to analyze the data.

Results:
The prevalence of dental service use in this sample was 13%. Most of the visits were because of pain/tooth removal. “No dental problem” was cited as the main reason for never having visited the dentist. Overall dental caries prevalence was 52.5%. The prevalence of dental caries was higher in those who had visited the dentist before (P < 0.001).

Conclusions:
A very low dental service use was observed among 12- and 15-year old children in this study. The visits were mainly for pain alleviation rather than prevention of oral health. Lack of perceived need was the major barrier for accessing dental care.
Antibacterial activity of Urena lobata against uropathogens
Authors: Garuba Taofeeq , Katrodiya Nency , Patel Nikita , Patel Swetal , Rajani Dhanji. P. , Chettiar Shiva Shankaran , AbdulRahman A.A. , Krishnamurthy R. 
Published: October 2021

Urinary tract infections (UTI) are one of the most common form of bacterial infections but the treatment becomes cumbersome as the etiological bacteria are developing resistance against antibiotics. This present study evaluated the efficacy of antimicrobial activity of Urena lobata against uropathogens. Six urine samples from UTI patients were collected from Pathological Laboratory, G.B. Vaghani Multispecialty Hospital, Surat. Bacteria were isolated from these samples using Nutrient agar, Mac Conkey agar plate, Blood agar, Mannitol salt agar, Eosin Methylene Blue agar and King’s agar. The bacterial isolates were identified using cultural characteristics, microscopic features and biochemical characteristics. Leaf extract of Urena lobata was prepared using Soxhlet Extraction Method whereby methanol and distilled water were the extractants used. Herbal extract disc was prepared at concentrations of 50,75, and100 mg/ml and tested against all the isolates. DMSO and antibiotics (Nitrofurantion, Amikacin, Levofloxacin, Norofloxacin, Ofloxacin and Cephalosporins) were used as negative and positive controls respectively.Staphylococcus aureus, Escherichia coli, Bacillus cereus, Streptococcus pneumoniae, Klebsiella spp. and Brevibacillus panacihumi were isolated from the urine samples. All concentrations of aqueous and methanolic extracts of U. lobata leaf displayed highest zone of inhibition against B. cereus. No inhibitory effect was observed against the growth of Klebsiella except at the highest concentrations. Further study is encouraged on the in-vivo study of efficacy of U. lobata on etiological agent of UTI.
Bioassay-guided isolation of cytotoxic constituents of Aframomum melegueta K.Schum. seeds
Authors: Ambali Owoola Azeezat , Oguntimehin Samuel Ayoolu , Ajaiyeoba Edith Oriabure , Ogbole Omonike Oluyemisi , Adeniji Adekunle Johnson 
Published: October 2021

The seeds of Aframomum melegueta are used extensively in the Nigerian ethnomedicine for the management of cancer. This study therefore aimed at isolating and characterizing its cytotoxic constituents. Methanol extract of the seed was obtained through cold maceration, and it was further partitioned into n – hexane, dichloromethane and ethylacetate. The most active fraction was purified on repeated chromatographic techniques, using vacuum liquid chromatography (VLC), column (CC), and high-performance liquid chromatography (HPLC). The extract, purified fractions and isolated compounds were tested for their cytotoxic activities against the human Rhabdomyosarcoma (RD) and breast (MCF-7) cancer cell lines, using MTT assay. The crude extract and n-hexane fraction were found to be selectively cytotoxic to the cancer cell lines. Bioassay-guided fractionation of the n-hexane fraction led to the isolation of three compounds, which were identified as 6-shogaoal, 6-paradol, and 1-dehydro-6-gingerdione. 6-shogaoal demonstrated the highest cytotoxicity with CC50 values of 0.11 ± 0.02 and 0.25 ± 0.05ìg/mL against RD and MCF-7 cell lines respectively, and these were higher in activity when compared with cyclophosphamide (CC50 = 1.98 ± 0.15 and 0.71 ± 0.7ìg/mL). The presented data validates the ethnomedicinal use of A. melegueta in the treatment of cancer and is also indicative of the potential of 6-shogaol as an anticancer agent.
IDENTIDADE INTERCULTURAL E AS POSSIBILIDADES DE APRENDIZAGEM EDUCACIONAL DIALÓGICA
Authors: Coelho Marciele Nazaré 
Published: October 2021

O presente artigo tem como foco de análise as múltiplas aprendizagens em contextos educativos, considerando os aportes da interculturalidade e da identidade intercultural como possibilidade para o diálogo entre e no interior das diferentes culturas, etnias e povos. A partir das vivências de crianças angolanas, identificamos os fatores transformadores e os fatores excludentes para um processo educativo à favor da diversidade cultural, racial, étnica, de modos de viver, pensar e a constituição das identidades livres e plurais, dentro do quadro de referência da metodologia comunicativa. A perspectiva intercultural se coloca como uma saída dentro das perspectivas duais, proporcionando aprendizagens, diálogos, vivências e ações mais dialógicas entre as crianças angolanas de diferentes etnias e fornece subsídios para uma educação intercultural na escola brasileira.
Palavras-chave: Identidade. Interculturalidade. Igualdade de diferenças. Aprendizagens. Angola.
MULHERES NEGRAS E PARDAS E CIDADANIA
Authors: Dutra Priscilla Tatianne , Carvalho Guilherme Paiva de 
Published: October 2021

O artigo tem como objetivo geral analisar os efeitos da discriminação racial no (não) reconhecimento e na cidadania de um grupo de mulheres negras e pardas. Estruturamos a pesquisa em critérios metodológicos próprios, exploratórios e qualitativos, por meio de levantamento bibliográfico e análise de narrativas (auto)biográficas em um diálogo reflexivo com escuta sensível de um grupo colaborativo formado por mulheres autodeclaradas negras e pardas. Como aporte teórico para discussões e análise de resultados optou-se por autoras contra hegemônicas como Lilia Schwarcz (1993), Gayatri Spivak (2010) e Nancy Fraser (2007). A análise mostra como se dão os efeitos da discriminação no (não) reconhecimento e na cidadania de mulheres negras e pardas destacando-se entre os efeitos conforme narrativas a recorrência dos temas racismo, sexismo e subalternidade. O estudo evidencia a necessidade de políticas públicas para o combate à discriminação racial de mulheres negras e pardas de maneira individual e coletiva.
Palavras-chave: Mulheres negras. Mulheres pardas. (Não) Reconhecimento. Discriminação. Cidadania.
INTERCULTURALISMO(S) E IMIGRAÇÃO: ALGUMAS QUESTÕES A PARTIR DA EXPERIÊNCIA PORTUGUESA E ESPANHOLA
Authors: Ennes Marcelo Alario 
Published: October 2021

O problema que o presente artigo se propõe a investigar refere-se à pertinência do interculturalismo para a questão imigratória, em especial, em Portugal e na Espanha. Seu argumento central baseia-se em uma perspectiva polissêmica sobre interculturalismo, isto é, o interculturalismo como chave analítica, como expressão de políticas de integração e gestão e como tradução da sociedade do consumo. Propomos, assim, que o interculturalismo oferece possibilidades analíticas para compreender a diversidade cultural e suas tensões entre diferenças e desigualdades, que dentro dos limites políticos dos Estados-nação representou avanços quando comparado com outros modelos anteriores e nos permite pensar várias dimensões da diversidade cultural produzida pela presença de imigrantes. O artigo foi desenvolvido com base em pesquisa bibliográfica, observação direta e entrevistas qualitativas e pretende oferecer contribuições para pensar os limites e avanços do debate teórico e político sobre as questões migratórias em especial nos 15 primeiros anos do século XXI.
Palavras-chave: Interculturalismo. Políticas imigratórias. Sociedade do consumo. Chave-analítica.
A VIOLÊNCIA ESTRUTURAL DOS FEMINICÍDIOS NA LITERATURA LATINO-AMERICANA
Authors: Gomes Carlos Magno 
Published: October 2021

Este estudo apresenta reflexões sobre a impunidade estrutural que atravessa as representações de feminicídio nas narrativas de Marina Colasanti, Arminé Arjona e Selva Amada, que contextualizam esse crime em sistemas patriarcais do Brasil, México e Argentina, respectivamente. Este recorte analisará como os códigos machistas relativizam a impunidade de criminosos ao mesmo tempo em que promovem a culpabilização e a desqualificação da vítima. Neste estudo, exploramos as representações literárias como arquivos sociais, levando em conta os conceitos de violência estrutural e as abordagens feministas de Rita Laura Segato (2013), Julia Fragoso (2010) e Lia Zanotta Machado (2010). Metodologicamente, a violência está sendo vista como um código machista de punição e controle do corpo da mulher.
Palavras-chave: Violência contra a mulher. Literatura comparada. Códigos misóginos.