bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances
Authors: Rukavina Katarina , Staunton Juliet , Zinzalias Pavlos , Skoric Magdalena Krbot , Poplawska‐Domaszewicz Karolina , Pisani Antonio , Bannister Kirsty , Chaudhuri K Ray 
Published: December 2024

AbstractBackgroundParkinson's disease (PD) is the second most common neurodegenerative disease. Over two thirds of People with Parkinson's (PwP) live with chronic PD‐related pain, but its successful management remains an unmet need. Unrevealing links between pain and other motor and non‐motor symptoms (NMS) of PD may accelerate delivery of much needed precision pain medicine approaches for PwP.MethodsAn exploratory, cross‐sectional analysis of the prospective, observational, multicentre, international study ‘The Non‐motor International Longitudinal, Real‐Life Study in PD ‐ NILS’.ResultsIn 109 PwP (41.3% women, age 64.29 ± 9.80 years, disease duration 5.50 (2.44–10.89) years, H&Y stage 2 (1–4), levodopa equivalent daily dose 575.00 (315.00–1004.00) mg), strong correlations were noted between the total burden of PD‐related pain and the total NMS burden (rs = 0.641) and moderate with disturbances of sleep/fatigue (rs = 0.483), cognitive issues (rs = 0.445), motor complications (rs = 0.421), anxiety (rs = 0.441) and depression (rs = 0.451). In a multivariate linear regression analysis, motor complications (B = 2.063, 95% CI for B 1.152–2.974, p < 0.001), sleep disturbances/fatigue (B = 0.392, 95% CI for B 0.064–0.720, p = 0.020) and anxiety (B = 0.912, 95% CI for B 0.165–1.659, p = 0.017) significantly impacted the overall burden of pain.ConclusionsIn PwP, PD‐related pain is significantly impacted by motor complications, anxiety and sleep disturbances. A personalized, tailored approach to management of pain in PwP need to accurately identify and tackle all its interrelated symptoms. Whether successful management of motor complications, anxiety and sleep disturbances may contribute to pain relief in PwP for specified cohorts needs to be a focus of future randomized controlled clinical trials.Significance statementThis explorative analysis identifies the frequent overlap of chronic pain, motor complications, sleep disturbances and anxiety in Parkinson's disease and could help advance the development of precise and effective pain management strategies tailored to the needs of People with Parkinson's.
Antidune simulations using continuum‐based models
Authors: Escauriaza Cristián , Williams Megan 
Published: December 2024

AbstractThe interactions of supercritical flows with sand or gravel beds in river channels or tidal inlets lead to the formation of antidunes. These bedforms are generally identified as nearly periodic sedimentary patterns of symmetrical shape that are in phase with the surface waves in the flow and have important effects on flow resistance and bedload transport. In addition, they play a fundamental role on morphodynamical processes in estuarine systems, on the scour around hydraulic infrastructure, and their bed signature can help to interpret paleofloods from sedimentary records. Despite the importance and ubiquity of antidunes in environmental flows, very few numerical simulations have captured their dynamics. In this work, we develop a model that couples the shallow‐water and Exner equations in two‐dimensions (2D) and demonstrate that a higher‐level theory can reproduce the experimental antidune results of Pascal et al. (2021), independent of interactions at the particle scale. The flows are characterised by Froude numbers between 1.31 and 1.45, sediment diameters of mm and with 3° mean bed slopes. Using this information, we aim to identify the minimum requirements for a numerical model to capture in detail the migration of these bedforms. We use spectral analysis and compute statistics of bed elevation to determine the relevant temporal and spatial scales associated to the antidune propagation. The results of the model yield new insights on the mechanisms of bedform migration, providing tools to improve their description and assess the morphodynamic feedbacks.
From Economic Policy Uncertainty to Implied Market Volatility: Nothing to Fear?
Authors: Yang Lu 
Published: December 2024

ABSTRACTThis paper investigates the interdependence between economic policy uncertainty (EPU) and implied market volatility using a Bayesian copula network. The results indicate that market‐implied volatilities serve as more reliable forward‐looking indicators of uncertainty compared to newspaper‐based EPU. Through a complex partial wavelet coherence approach, the study further explores the dynamic interdependence between these variables, revealing the specific time‐domain patterns of their effects on economic uncertainty and the conditions under which they can be distinguished as measures of risk aversion and ambiguity aversion. Notably, the findings suggest that, in the short time scales, the media tends to generate ambiguity, contributing to belief divergence among market participants. However, over longer time scales, EPU increasingly reflects economic uncertainty. These insights are valuable for gaining a deeper understanding of the media's role in conveying information and the behavioral traits influencing economic decision‐making.
Prophylactic HPV vaccination in HPV‐related gynecologic cancers: European Society of Gynecological Oncology (ESGO) prevention committee opinion
Authors: Bizzarri Nicolò , Kyrgiou Maria , De Vincenzo Rosa , Zapardiel Ignacio , Razumova Zoia , Taumberger Nadja , Toth Ico , Theofanakis Charalampos , Gultekin Murat , Joura Elmar A. 
Published: December 2024

AbstractMany clinicians recommend that patients diagnosed with HPV‐related gynecologic cancers receive prophylactic HPV vaccination at the time of cancer diagnosis or after cancer treatment. In view of the large use of such practice, we aimed to assess the literature evidence supporting the use of prophylactic HPV vaccines after diagnosis or treatment of HPV‐related gynecologic cancers. Women who develop HPV‐related cervical, vaginal, and vulvar cancers represent a subgroup of patients who may be particularly sensitive to HPV infection and re‐acquire infections. The rationale that the use of prophylactic HPV vaccination at the time or after treatment for cervical, vaginal, and vulvar cancers might reduce the risk of future HPV‐related diseases might be explained by the data coming from the use of HPV vaccination after treatment of pre‐invasive disease; however, the evidence on the use of HPV vaccination in the setting of HPV‐related gynecologic cancers is currently absent. In this context, observational and experimental studies document an important drop in effectiveness of HPV vaccination by age. Physicians should be aware of catch‐up programs in their countries and should be ready to counsel patients about prophylactic HPV vaccine efficacy according to their age. In general, no evidence exists supporting the use of prophylactic HPV vaccine in patients diagnosed with HPV‐related gynecologic cancers; therefore, the European Society of Gynecological Oncology (ESGO) prevention committee opinion is to counsel these patients as any HPV‐related non‐gynecologic cancer (such as anal or oropharyngeal cancer) and non‐cancer patient, suggesting vaccination according to patient's age and prognosis, knowing there is a decrease of efficacy with increasing age. Studies on the use of prophylactic HPV vaccine in patients diagnosed with HPV‐related gynecologic cancers are strongly needed.
Cesarean section: One procedure, varied techniques. Detailed observations of 1013 first cesarean sections in a tertiary hospital in Ghana
Authors: Asah‐Opoku Kwaku , Heesterman Tessa , Zeevaert Mona Lu , Agyabeng Kofi , Browne Joyce L. , Damale Nelson , Grobbee Rick , Nuamah Mercy A. , Bloemenkamp Kitty W. M. , Rijken Marcus J. 
Published: December 2024

AbstractObjectiveCesarean sections (CS) are among the most performed surgical procedures in the world. Small variations in surgical techniques could have a significant impact on a global scale, for example, in postoperative complications. In the present study we aimed to observe and audit every single step used during first time CS.MethodsDescriptive cross‐sectional study from January 1, 2018 to January 14, 2020 at a tertiary hospital in Ghana. Techniques used for CS were directly observed and thoroughly documented. Standard descriptive methods were used for data analysis.ResultsOf the 1013 first time CS, 81.4% were emergency procedures. The mean (SD) gestational age at CS was 38.4 ± 3 weeks. Low transverse incision was used in 993/1013 (98%) of cases. Blunt dissection of subcuticular tissue was done in 48/1013 (4.7%), blunt separation of rectus fascia in 386/1013 (38.1%), blunt opening of peritoneum in 838/1013 (82.7%) and lower uterine segment incision with scalpel in 995/1013 (98.2%) women. A total of 916/1013 (90.4%) had double layered uterine closure, 961/1013 (94.9%) had uterus exteriorized for repair, 382/1013 (37.7%) had closure of the peritoneum, 655/1013 (64.7%) had non‐closure of the rectus muscle, 677/1013 (66.8%) had subcutaneous tissue closed and 983/1013 (97.0%) had skin closed with subcuticular stitches. There were 493 different combinations of techniques observed performed by 85 surgeons for carrying out a complete first time CS.ConclusionThere is a wide variety of methods used for first time CS. There is the need for training and retraining on the techniques for CS using evidence‐based guidelines.
Keratinocyte exosomal LOC285194 ameliorates psoriasis by inhibiting the differentiation of CD4+T cells to Th17 cells through regulating miR‐211‐5p/SIRT1 axis
Authors: Lin Jin , Cao Yi , Ma Lili , Tao Maocan , Yang Xiaohong 
Published: December 2024

AbstractKeratinocytes exosome participates in the pathogenesis of psoriasis and exosomes always carry long non‐coding RNAs (lncRNAs) into target cells to function as an essential immune regulator in psoriasis‐related diseases. LncRNA LOC285194 is closely associated with the occurrence of psoriasis. However, whether keratinocyte exosomal LOC285194 participates in the process of psoriasis remains vague. Exosomes were authenticated by transmission electron microscope and nanoparticle tracking analysis (NTA). Relative gene expression was determined by reverse transcription‐polymerase chain reaction (RT‐PCR). Flow cytometry was used to monitor the proportion of immune cells. Fluorescence in situ hybridization was employed to determine the colocalization of lncRNA and miRNA. Keratinocyte exosomal LOC285194 was reduced in psoriasis patients and had a negative association with Th17 cell infiltration in psoriasis patients. LOC285194‐downregulation contributed to the differentiation of CD4+T cells to Th17 cells. Cytokine cocktail treatment reduced LOC285194 expression in keratinocytes and keratinocyte exosome, subsequently promoted the differentiation of CD4+T cells to Th17 cells and Th17 cells‐related molecular levels including IL‐17A, IL‐22 and TNF‐α, which were notably abrogated by LOC285194‐upregulation in keratinocytes. As a sponge of LOC285194, miR‐211‐5p inhibition induced the increase of Th17 cell proportion in CD4+T cells, while exosomes treatment isolated from cytokine cocktail‐exposed keratinocytes further enhanced Th17 cell proportion, which were abolished by LOC285194 overexpressed‐exosome treatment. Furthermore, silent information regulator 1 (SIRT1) mediated the regulation role of miR‐211‐5p on Th17 cell production. Combined with the imiquimod‐induced psoriasis animal model, exosomes isolated from LOC285194‐overexpressing keratinocytes relieved psoriasis symptom through regulating miR‐211‐5p/SIRT1 axis. LOC285194 upregulation in keratinocytes promoted the keratinocyte exosomal LOC285194, that could be absorbed by CD4+T cells, leading to the inhibition of Th17 cell differentiation through targeting miR‐211‐5p/SIRT1 axis. This study provides a novel molecular mechanism of Th17 cell accumulation‐mediated psoriasis.
Integration of Optical Coherence Tomography Images and Real‐Life Clinical Data for Deep Learning Modeling: A Unified Approach in Prognostication of Diabetic Macular Edema
Authors: Atik Muhammed Enes , Kocak İbrahim , Sayin Nihat , Bayramoglu Sadik Etka , Ozyigit Ahmet 
Published: December 2024

ABSTRACTThe primary ocular effect of diabetes is diabetic retinopathy (DR), which is associated with diabetic microangiopathy. Diabetic macular edema (DME) can cause vision loss for people with DR. For this reason, deciding on the appropriate treatment and follow‐up has a critical role in terms of curing the disease. Current artificial intelligence (AI) approaches focus on OCT images and may ignore clinical, laboratory, and demographic information obtained by the specialist. This study presents a novel deep learning (DL) framework for evaluating the visual outcome of the TREX anti‐VEGF intravitreal injection regimen. DL models are trained to extract deep features from OCT and ILM topographic images and the obtained deep features are combined with patients' demographic, clinical, and laboratory findings to predict the direction of the treatment process. When the ResNet‐18 network is used, the proposed DL framework is able to predict the prognosis status of patients with the highest accuracy.
Enhancing meniscal repair with tough adhesive puncture sealing (TAPS) suture: A proof‐of‐concept study on bovine cadaveric knees
Authors: Lamer Stephanie , Mazy David , Nault Marie‐Lyne 
Published: December 2024

AbstractPurposeThe objective was to use cyclic tensile loading to compare the gap formation at suture site of three different suture materials to repair bovine radial meniscal tears: (1) polyglactin sutures, (2) tough adhesive puncture sealing (TAPS) sutures and (3) ultra‐high molecular weight polyethylene (UHMWPE) sutures.MethodsTwelve ex vivo bovine knees were dissected to retrieve the menisci. Complete radial tears were performed on 24 menisci, which were then separated into three groups and repaired using either pristine 2–0 polyglactin sutures, TAPS sutures (2–0 polyglactin sutures coated with adhesive chitosan/alginate hydrogels) or 2‐0 UHMWPE sutures with a single stitch. The repaired menisci were clamped onto an Instron machine and underwent cyclic loading between 5 and 25 N at a frequency of 0.16 Hz. Gap formation between the edges of the tear was measured after 500 cycles using an electronic caliper, when the meniscus was still on the Instron without any load applied.ResultsMean gap formation was 5.22 mm (±1.70) for the 2–0 polyglactin sutures, 2.48 mm (±0.25) for the TAPS sutures, and 4.85 mm (±1.55) for the 2–0 UHMWPE sutures. The gap was significantly smaller in the TAPS sutures group compared to the two others because of better force dispersion, decreasing tissue damage by suture indentation and potentially leading to better meniscal healing.ConclusionsFrom a biomechanical standpoint, coated sutures held the edges of radial meniscal tears closer together compared to conventional sutures. This technology has the potential to reduce tissue damage and improve the success rate of meniscal repairs.Level of Evidencecontrolled laboratory study.
Future Organizational Identification: Visionary Leadership Gives Me Foresight to Identify With My Organization in the Future
Authors: Wang Ting , Lam Wing , Chen Ziguang , Yu Qionglei , Geng Xiaowei 
Published: December 2024

ABSTRACTThis research introduces the concept of future organizational identification (FOI), an extension of organizational identification (OI) that emphasizes its forward‐looking aspect. FOI refers to an individual's projection of their self‐definition based on the continuity of their organizational membership. Drawing on construal level theory (CLT) and a future‐oriented approach, this research investigates how visionary leadership, which offers vision communication and vision of continuity, may enhance followers' FOI through future focus. Study 1, comprising Studies 1a and 1b, validates the measurement of FOI in workplace contexts. With a three‐wave, time‐lagged investigation, Study 2 demonstrates that leaders' vision communication fosters followers' FOI by promoting future focus, and vision of continuity positively moderates this mediation effect. These findings advance literature on organizational identification, visionary leadership, and CLT. We conclude by discussing the theoretical and practical implications of our findings and proposing directions for future research.
Creativity: Exploring Factor Structure of the Torrance Tests of Creative Thinking in Chinese Preschoolers
Authors: Xu Xinpei , Chen Yu , Ye Xiaolin , Zhang Jinghui , Luan Jinxin , Li Yan 
Published: December 2024

ABSTRACTThis study investigated the structural exploration of creativity in Chinese preschoolers using the Torrance Tests of Creative Thinking‐Figural (TTCT‐Figural). The participants were 256 children aged 4–6 from a public kindergarten in Shanghai, with an average age of 4.79 years (SD = 0.63). Building upon prior research and integrating Kirton's Adaptive‐Innovative theory, this study examined both single‐factor and two‐factor models. The results indicated that the superiority of the two‐factor models over the single‐factor model, with optimal fit indicating fluency and originality loading on the innovative factor and elaboration, abstractness of titles, and creative strengths loaded on the adaptive factor. Resistance to premature closure was found to load on both adaptive and innovative factors. Gender invariance analysis indicated no significant differences between boys and girls, highlighting the consistency of the creativity construct regardless of gender. The confirmatory factor analyses underscored the efficacy of the two‐factor model, offering valuable insights into the creative thinking processes of Chinese preschoolers assessed through TTCT‐Figural. These findings enhance our understanding of creativity in early childhood education, emphasizing the significance of gender‐neutral creativity evaluations at this developmental stage.
A flat posterior cruciate ligament reconstruction restores native knee kinematics, comparable to a double‐bundle reconstruction—A biomechanical robotic investigation
Authors: Deichsel Adrian , Gellhaus Florian , Peez Christian , Raschke Michael J. , Martinovic Moritz , Herbst Elmar , Herbort Mirco , Fink Christian , Kittl Christoph 
Published: December 2024

AbstractPurposeTo biomechanically evaluate a flat posterior cruciate ligament (PCL) reconstruction utilizing rectangular femoral bone tunnels.MethodsEight fresh‐frozen human knee specimens were tested in a six‐degrees‐of‐freedom robotic test setup. In each testing step, a force‐controlled test protocol was performed, including 89 N posterior tibial translation (PTT) in neutral, internal and external rotation, from 0 to 90° of flexion. After determining the native knee kinematics, the PCL was cut. Subsequently, a flat PCL reconstruction (PCLR) with a rectangular bone tunnel was performed, utilizing a quadriceps tendon autograft with a patellar bone block. After filling the bone tunnel, a single‐bundle PCLR without and with femoral interference screw fixation, as well as a double‐bundle reconstruction, was performed. Statistical analysis was performed using mixed linear models.ResultsCutting of the PCL led to significant (p ≤ .05) increases in PTT, from 0 to 90° of flexion, up to 10.7 mm, in comparison to the native state. After flat reconstruction and double‐bundle reconstruction, no significant difference was found between the native and reconstructed state (p ≥ .05). The single‐bundle PCLR without interference screw showed significantly increased PTT in comparison to the native state in 30° (mean difference [MD] 3.3 mm; 95% confidence interval [CI] 1.3 – 5.2 mm; p < .001), 60° (MD 4.4 mm; 95% CI 2.5–6.4 mm; p < .001) and 90° of flexion (MD 4.0 mm; 95% CI 2.1–6.0 mm; p < .001). The single‐bundle PCLR with additional interference screw showed significantly increased PTT in comparison to the native state only in 30° (MD 1.9 mm; 95% CI 0.05–3.8 mm; p = .01).ConclusionBoth a flat and a double‐bundle PCLR were able to restore the native knee kinematics in all tested flexion angles. A single‐bundle reconstruction was not able to fully restore native kinematics, with only small residual anteroposterior instability.Level of EvidenceNot applicable (an experimental laboratory study).
The use of an imageless robotic system in revision of unicompartmental knee arthroplasty
Authors: Andriollo Luca , Benazzo Francesco , Cinelli Virgina , Sangaletti Rudy , Velluto Calogero , Rossi Stefano Marco Paolo 
Published: December 2024

AbstractPurposeThe application of robotics in revision arthroplasty particularly from unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA), is underexplored. The purpose of this study is to describe the surgical technique of an imageless robotic system used in the revision of UKA to TKA and to evaluate short‐ to mid‐term outcomes.MethodsThis prospective study includes 35 patients treated from May 2020 to July 2023. Demographic data of the patients were gathered and the reasons for needing revision surgery were assessed. All patients were clinically evaluated preoperatively and at the final follow‐up of 31.3 ± 12.1 months, using the Western Ontario and McMaster Universities Arthritis Index (WOMAC), Oxford Knee Score (OKS), Forgotten Joint Score (FJS‐12), Numerical Rating Scale (NRS) and range of motion (ROM). Additionally, a radiographic evaluation was performed, and implant survival was assessed by analyzing complications at final follow‐up.ResultsIn 88.6% of the patients, a primary Posterior Stabilized (PS) or Constrained Posterior Stabilized prosthetic implant was used, with 11.4% of patients requiring a varus‐valgus constraint implant. In 71.4% of the cases, a thinnest size liner of 10 mm was used. The use of the robotic system was never aborted for any reason. At final follow‐up, the implant survival rate was 97.14%. Average OKS increased from 31.4 ± 9.4 to 41.5 ± 4.3, FJS‐12 from 47.3 ± 19.3 to 80.7 ± 8.9; WOMAC at final follow‐up was 17.8 ± 8.7, from 53.5 ± 21.3 preoperatively. Analyzing ROM, NRS and patient‐reported outcome measures, there were significant differences in each parameter between prerevision surgery and final follow‐up.ConclusionsThis study highlights that in a cohort of patients undergoing robotic‐assisted conversion from UKA to TKA, the use of an imageless procedure incorporating intraoperative bone morphing and alignment based on a functional philosophy has proven to be safe and has yielded excellent clinical and radiographic outcomes.Level of EvidenceLevel II, prospective cohort study.