bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improvement on Martin–Hou equation of state for more precise prediction in the liquid region
Authors: Yao Guang , Yang Chengang , Hu Dong , Zhu Quan , Li Xiangyuan 
Published: December 2021

AbstractA modified Martin–Hou (M–H) equation of state (EOS) for the accurate representation of thermodynamic property data of some pure substances in liquid phase is presented in this work. The improvement is achieved by substituting a new parameter η into the original M–H EOS. Eighteen pure substances are chosen to construct the dependency relationship of η on reduced temperature Tr and acentric factor ω. Furthermore, to verify the effectiveness and improvement of the modified M–H EOS, the calculated values of the saturated vapor and liquid molar volumes are compared with the literature data in the reduced temperature ranging from approximately 0.6 to 1.0. The results show that the modified M–H EOS perform a good prediction in gaseous phase for pure substances with the average absolute deviation (AAD) generally less than 1%, and more precise liquid molar volume values can be obtained with the modified equation. In liquid phase, the AAD of the modified M–H EOS is 3.71%, which is much lower than 6.16% of the original M–H EOS.
Maximizing batch fermentation efficiency by constrained model‐based optimization and predictive control of adenosine triphosphate turnover
Authors: Espinel‐Ríos Sebastián , Bettenbrock Katja , Klamt Steffen , Findeisen Rolf 
Published: December 2021

AbstractWe present a constrained model‐based optimization and predictive control framework to maximize the production efficiency of batch fermentations based on the core idea of manipulating adenosine triphosphate (ATP) wasting. In many bioprocesses, enforced ATP wasting —rerouting ATP use towards an energetically possibly suboptimal path— allows increasing the metabolic flux towards the product, thereby enhancing product yields and specific productivities. However, this often comes at the expense of lower biomass yields and reduced volumetric productivities. To maximize the overall efficiency, we formulate ATP wasting as a model‐based optimal control problem. This allows for balancing trade‐offs between different objectives such as product yield and volumetric productivity for batch fermentations. Unlike static metabolic control, one obtains a higher degree of flexibility, adaptability, and competitiveness. This can be advantageous towards achieving a sustainable and economically efficient biotechnology industry. To compensate for model‐plant mismatch, disturbances, and uncertainties, we propose not only solving the optimal control problem once. Instead, we exploit the concept of moving horizon model predictive control combined with constraint‐based dynamic modeling to capture the fermentation dynamics. The approach is underlined considering the industrially relevant bioproduction of lactate by Escherichia coli. We discuss practical challenges for the described control strategy and provide an outlook towards future developments.
Comprehensive analysis on anomalous phenomenon of ethanol‐soluble poly(vinyl butyral) membrane for ethanol recovery via pervaporation
Authors: Li Junjun , Huang Mi , Wei Ping , Zhang Yaqin , Zhao Xuean , Liu Chunbo , Zhou Zhijun , Zhang Lin 
Published: December 2021

AbstractPoly(vinyl butyral) (PVB) is selected as a promising ethanol‐permselective membrane based on the solubility parameter theory; however, it exhibits anomalous water perm‐selectivity in practical pervaporation (PV) process. Comprehensive analysis based on experimental and theoretical methods were carried out to explore the inherent mechanism of the anomalous performance. Firstly, sum frequency generation vibrational spectra and contact angle were developed to quantify the surface reconstruction of membrane in air and ethanol, which indicated that hydrophilic hydroxyl tended to expose on membrane surface with ethanol thus improving the membrane affinity to water. Meanwhile, swelling behaviors proved more water would accumulate in the ethanol swollen membrane. Furthermore, theoretical analysis in terms of sorption and diffusion process, based on the UNIFAC‐FV model and Fujita free‐volume theory, confirmed the mechanism of anomalous phenomenon of PVB membrane. The comprehensive investigation was expected to provide insights into the basic separation mechanism of PV process.
High‐Efficiency Generation of Flat High‐Order Sidebands in a Gently Modulating Optomechanical System
Authors: Liu Jun‐Hao , Yu Ya‐Fei , Wang Jin‐Dong , Zhang Zhi‐Ming 
Published: December 2021

AbstractThe high‐order sideband generation in a gently modulating optomechanical system, which consists of a standard optomechanical system driven by a mildly amplitude modulated field (MAMF) is investigated. It is found that the sideband generation can be effectively optimized by choosing an appropriate component number N of the MAMF, and this scheme can generate more and flatter high‐order sidebands with the same input power compared with the conventional model. The efficiency of the sideband generation is much superior to the traditional scheme. The challenge for high‐efficiently realizing a flat optical frequency comb based on optomechanical systems may be aided by this work.
Developing LC–MS/MS methods to quantify rivaroxabanin human plasma and urine: Application to therapeutic drug monitoring
Authors: Zheng Xin , Chen Chen , Gao Huitao , Sun Xuefeng , Zhang Yanbao , Shi Juhong , Han Xiaohong 
Published: December 2021

AbstractRivaroxaban is an oral anticoagulant directly inhibiting the activity of Factor Xa, which is widely used for the prophylaxis of thromboembolic disorders. Therapeutic drug monitoring (TDM) is required during therapy for individual dosage adjustment. This study aimed at developing a liquid chromatography/tandem mass spectrometry method that was suitable for rivaroxaban TDM in human plasma and urine and exploring the feasibility of urine drug monitoring in medical care. A 3 min run time of the LC–MS/MS methods was established by employing an Acquity UPLC BEH C18 (2.1 × 50 mm, 1.7 μm) column using gradient elution of 10 mmol/L ammonium acetate containing 0.1% formic acid–0.1% formic acid acetonitrile as a mobile phase at a flow rate of 0.4 ml/min with calibration ranges of 0.5–400 and 10–10,000 ng/ml for human plasma and urine, respectively. Rivaroxaban was detected on a triple quadrupole tandem mass spectrometer with an electrospray ionization source in positive ion mode. The methods showed good linearity within the calibration range. The precision and accuracy, matrix effect, extraction recovery and stability in both human matrices were all validated and meet the international guideline requirements. These validated methods were successfully applied to support the TDM of an aged patient receiving rivaroxaban for therapy.
Translation of Runge's 1873 publication “On the etiology and treatment of writer's cramp”: The first description of “tennis elbow”
Authors: Stegink‐Jansen Caroline W. , Jung Beate , Somerson Jeremy S. 
Published: December 2021

AbstractThis publication by Dr Ferdinand Runge is ubiquitously credited as first to describe the symptoms, pathology, and treatment of patients with lateral epicondylosis (tennis elbow). However, the main focus of his work was to provide insight into causes of writer's cramp and treatments for the condition, elegantly illustrated in four case reports. This work, recently cited as unavailable, is written in German. Given the high frequency of citations in the English literature, it was considered useful to translate it into English to widen access to a broader readership. The purpose of this project was briefly to introduce the life and clinical expertise of Dr. Ferdinand Runge and the content of his work, followed by a translation of the entire manuscript into English. The paper was translated by the three authors using a process of sequential consensus. All are proficient in German and English, with clinical expertise in both topics. A brief reflection is provided to place Dr Runge's observations, clinical reasoning, and contemporaneously available treatments in the context of current thinking about lateral epicondylalgia. Dr. Runge shares his expertise, carefully reporting pertinent examination findings for each case, sharing hypotheses about the etiology of writer's cramp, and using the effectiveness of his applied treatment as confirmation. He concludes that careful evaluation of the patient's activities that hindered writing prior to the onset of the writer's cramp is key to managing this ailment. The topics addressed in this classic work are still thought‐provoking.
Synthesizing magnetic graphene oxide nanomaterial (GO‐Fe3O4) and kinetic modelling of methylene blue adsorption from water
Authors: Tishbi Pedram , Mosayebi Mehdi , Salehi Zeinab , Fatemi Shohreh , Faegh Ehsan 
Published: December 2021

AbstractMethylene blue (MB) is a frequently used dye in several industries that is detrimental both to human health and aquatic ecosystems. Graphene oxide (GO) has the application potential for dye removal from wastewater due to its high specific surface area; however, it suffers from a labourious separation step. In this work, magnetic GO nanostructure was prepared by co‐precipitation of ferrous salts in presence of GO to achieve a GO‐Fe3O4 hybrid. By choosing the proper ratio of GO to Fe3O4, the specific surface area of 280.26 m2/g could provide excellent adsorption capacity; the superparamagnetic property of the prepared adsorbent also ensures its magnetic separation from aqueous solutions. The results of adsorption experiments revealed that, within 2 min, 93%, 80%, and 50% of MB were separated from the solutions of 100, 120, 150 mg/L dye concentration, respectively. The adsorption of MB followed a pseudo‐first‐order kinetic model, and the equilibrium isotherm study indicated that experimental data were well fitted to the Langmuir isotherm model. The impact of pH and adsorbent dosage were investigated, and the results showed that the amount of adsorbed MB onto the GO‐Fe3O4 was sharply increased to 231.6 and 246 mg/g by increasing pH and adsorbent dosage up to 6 and 15 g, respectively. Thermodynamic parameters indicated that the adsorption process of MB is endothermic and spontaneous. In addition, GO‐Fe3O4 revealed a good regeneration ability by using ethanol as the desorbent. These results suggest that the proposed adsorbent has promising potential in removing dye from water resources.
Natriuretic peptides to differentiate constrictive pericarditis and restrictive cardiomyopathy: A systematic review and meta‐analysis
Authors: Diaz‐Arocutipa Carlos , Saucedo‐Chinchay Jose , Imazio Massimo , Argulian Edgar 
Published: December 2021

AbstractPrevious studies have shown that natriuretic peptide levels are increased in patients with restrictive cardiomyopathy (RCM) but not in constrictive pericarditis (CP). We performed a systematic review and meta‐analysis to evaluate the diagnostic utility of B‐type natriuretic peptide (BNP) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) to differentiate CP and RCM. We searched electronic databases from inception to January 07, 2021. Studies involving adult patients that assessed the utility of natriuretic peptides to differentiate CP and RCM were included. All meta‐analyses were performed using a random‐effects model. Seven studies (four case‐control and three cohorts) involving 204 patients were included. The mean age ranged between 25.7 and 64.1 years and 77% of patients were men. BNP levels were significantly lower (standardized median difference [SMD], −1.48; 95% confidence interval [CI], −2.33 to −0.63) in patients with CP compared to RCM. The pooled area under the curve (AUC) of the BNP level was 0.81 (95% CI, 0.70–0.92). NT‐proBNP (SMD, −0.86; 95% CI, −1.38 to −0.33) and log NT‐proBNP (SMD, −1.89; 95% CI, −2.59 to −1.20) levels were significantly lower in patients with CP compared to RCM. Our review shows that BNP and NT‐proBNP levels were significantly lower in patients with CP compared to RCM. The pooled AUC of BNP level showed a good diagnostic accuracy to differentiate both conditions.
Numerical simulation in the abdominal aorta and the visceral arteries with or without stenosis based on 2D PCMRI
Authors: Peng Chen , Liu Junzhen , He Wei , Qin Wang , Yuan Tong , Kan Yuanqing , Wang Keqiang , Wang Shengzhang , Shi Yun 
Published: December 2021

AbstractIt is important to obtain accurate boundary conditions (BCs) in hemodynamic simulations. This article aimed to improve the accuracy of BCs in computational fluid dynamics (CFD) simulation and analyze the differences in hemodynamics between healthy volunteers and patients with visceral arterial stenosis (VAS). The geometric models of seven cases were reconstructed using the magnetic resonance angiogram (MRA) or computed tomography angiogram (CTA) imaging data. The physiological flow waveforms obtained from 2D Phase Contrast Magnetic Resonance Imaging (PCMRI) were imposed on the aortic inlet and the visceral arteries' outlets. The individualized RCR values of the three‐element Windkessel model were imposed on the aortic outlet. CFD simulations were run in the open‐source software: svSolver. Two specific time points were selected to compare the hemodynamics of healthy volunteers and patients with VAS. The results suggested that blood in the stenotic visceral arteries flowed at high speed throughout the cardiac cycle. The low pressure is distributed at stenotic lesions. The wall shear stress (WSS) reached 4 Pa near stenotic locations. The low time average wall shear stress (TAWSS), high oscillatory shear index (OSI), and high relative residence time (RRT) concentrated in the abdominal aorta. Besides, the ratios of the areas with low TAWSS, high OSI, and high RRT to the computational domain were higher in patients with VAS than which in the healthy volunteers. The individualized BCs were used for hemodynamic simulations and results suggest that patients with stenosis have a higher risk of blood retention and atherosclerosis formation in the abdominal aorta.
Description of longitudinal tumor evolution in a case of multiply relapsed clear cell sarcoma of the kidney
Authors: Yaguchi Tomoki , Kimura Shunsuke , Sekiguchi Masahiro , Kubota Yasuo , Seki Masafumi , Yoshida Kenichi , Shiraishi Yuichi , Kataoka Keisuke , Fujii Yoichi , Watanabe Kentaro , Hiwatari Mitsuteru , Miyano Satoru , Ogawa Seishi , Takita Junko 
Published: December 2021

AbstractBackgroundClear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor.CaseA 2‐year‐old boy was diagnosed with CCSK, which relapsed four times until he yielded to the disease at the age of 7 years. To characterize the longitudinal genetic alterations occurring in the present case, we performed targeted‐capture sequencing by pediatric solid tumors panel (381 genes) for longitudinally sampled tumors, including autopsy samples of metastasis. Internal tandem duplication of BCOR (BCOR‐ITD) was the only truncal mutation, confirming the previously reported role of BCOR‐ITD in CCSK.ConclusionAcquisition of additional mutations along tumor relapses and detection of metastasis‐specific mutations were reminiscent of the tumor progression and therapeutic resistance of this case, leading to clonal selection and a dismal fate.
SKI‐G‐801, an AXL kinase inhibitor, blocks metastasis through inducing anti‐tumor immune responses and potentiates anti‐PD‐1 therapy in mouse cancer models
Authors: Synn Chun‐Bong , Kim Sung Eun , Lee Hee Kyu , Kim Min‐Hwan , Kim Jae Hwan , Lee Ji Min , Jo Ha Ni , Lee Wongeun , Kim Dong Kwon , Byeon Youngseon , Kim Young Seob , Yun Mi Ran , Park Chae‐Won , Yun Jiyeon , Lim Sangbin , Heo Seong Gu , Yang San‐Duk , Lee Eun Ji , Lee Seul , Choi Hunmi , Lee You Won , Cho Jae Seok , Kim Do Hee , Park Sungho , Kim Jung‐Ho , Choi Yewon , Lee Sung Sook , Ahn Beung‐Chul , Kim Chang Gon , Lim Sun Min , Hong Min Hee , Kim Hye Ryun , Pyo Kyoung‐Ho , Cho Byoung Chul 
Published: December 2021

AbstractObjectivesAXL‐mediated activation of aberrant tyrosine kinase drives various oncogenic processes and facilitates an immunosuppressive microenvironment. We evaluated the anti‐tumor and anti‐metastatic activities of SKI‐G‐801, a small‐molecule inhibitor of AXL, alone and in combination with anti‐PD‐1 therapy.MethodsIn vitro pAXL inhibition by SKI‐G‐801 was performed in both human and mouse cancer cell lines. Immunocompetent mouse models of tumor were established to measure anti‐metastatic potential of SKI‐G‐801. Furthermore, SKI‐G‐801, anti‐PD‐1 or their combination was administered as an adjuvant or neoadjuvant in the 4T1 tumor model to assess their potential for clinical application.ResultsSKI‐G‐801 robustly inhibited pAXL expression in various cell lines. SKI‐G‐801 alone or in combination with anti‐PD‐1 potently inhibited metastasis in B16F10 melanoma, CT26 colon and 4T1 breast models. SKI‐G‐801 inhibited the growth of B16F10 and 4T1 tumor‐bearing mice but not immune‐deficient mice. An antibody depletion assay revealed that CD8+ T cells significantly contributed to SKI‐G‐801‐mediated survival. Anti‐PD‐1 and combination group were observed the increased CD8+Ki67+ and effector T cells and M1 macrophage and decreased M2 macrophage, and granulocytic myeloid‐derived suppressor cell (G‐MDSC) compared to the control group. The neoadjuvant combination of SKI‐G‐801 and anti‐PD‐1 therapy achieved superior survival benefits by inducing more profound T‐cell responses in the 4T1 syngeneic mouse model.ConclusionSKI‐G‐801 significantly suppressed tumor metastasis and growth by enhancing anti‐tumor immune responses. Our results suggest that SKI‐G‐801 has the potential to overcome anti‐PD‐1 therapy resistance and allow more patients to benefit from anti‐PD‐1 therapy.
Impact of the improved parallel kinetic coefficients on the helium and neon transport in SOLPS‐ITER for ITER
Authors: Makarov S.O. , Coster D.P. , Rozhansky V.A. , Voskoboynikov S.P. , Kaveeva E.G. , Senichenkov I.Y. , Stepanenko A.A. , Zhdanov V.M. , Bonnin X. 
Published: December 2021

AbstractNew Grad–Zhdanov module is implemented in the SOLPS‐ITER code and applied to ITER impurity transport simulations. Significant difference appears in the helium transport due to improved parallel kinetic coefficients. As a result, 30% decrease of the separatrix‐averaged helium relative concentration is observed for the constant helium source and pumping speed. However, for the neon changes are less pronounce. Change of the impurity behaviour is discussed. For the first time the ion distribution functions are studied in the ITER scrape‐off layer conditions to reveal the origin of the kinetic coefficient improvements and theory limitations.
Trauma exposure and mental health outcomes among Central American and Mexican children held in immigration detention at the United States–Mexico border
Authors: Sidamon‐Eristoff Anne Elizabeth , Cohodes Emily M. , Gee Dylan G. , Peña Catherine Jensen 
Published: December 2021

AbstractWe explored the associations between early‐life adversity and migration‐related stress on the mental health of Central American and Mexican migrating children held in United States immigration detention facilities. Migrating children have high rates of trauma exposure prior to and during migration. Early‐life adversity increases risk for developing mental health disorders. Forced separation of migrating children from their parents at the United States–Mexico border potentially exacerbates this risk. We sought to determine whether exposure to trauma prior to immigration and specific features of immigration detention were associated with posttraumatic stress symptomatology. We interviewed parents of 84 migrating children (ages 1–17) after families were released from immigration detention facilities to assess children's migration‐ and detention‐related experiences. A modified version of the University of California Los Angeles Posttraumatic Stress Disorder (PTSD) Reaction Index was administered to assess children's PTSD symptoms and document trauma exposure. A total of 97.4% of children experienced at least one premigration traumatic event. PTSD symptom severity was most strongly predicted by premigration trauma and duration of parent–child separation. This study contributes to a growing empirical literature documenting that early‐life adversity increases risk of developing mental health disorders, particularly following additional stress exposure, and that remaining with parents during immigration detention may help mitigate children's stress response.
Species densities, assembly order, and competence jointly determine the diversity–disease relationship
Authors: Rosenthal Lisa M. , Brooks Wesley R. , Rizzo David M. 
Published: December 2021

AbstractSince species vary in abundance and host competence (i.e., ability to get infected and transmit a pathogen), changes in species composition caused by biodiversity loss impacts disease dynamics. Forecasting effects of species composition on disease depends on community (dis)assembly, processes determining how species are added to (or lost from) communities. We simulated community assembly by planting mesocosms, nested along a richness gradient, and tested how relationships between richness, species assembly order, and overall density affect disease risk. Mesocosms with up to six crop species of varying competence were inoculated with a soilborne fungal pathogen, Rhizoctonia solani. Disease was measured as species‐level prevalence, community‐level prevalence, and total number of diseased plants. Regardless of metric, richness limited disease when species assembly order negatively correlated with competence and total density remained unchanged with richness. When density increased with richness or species assembled randomly, richness primarily correlated positively or weakly with disease. Our results align with theoretical expectations and represent the first empirical study to test the influence of species densities, assembly order, and competence on diversity–disease relationships.
Population responses of omnivorous arthropods to plant alternative resources suppress prey populations: A meta‐analysis
Authors: Rinehart Shelby , Long Jeremy D. 
Published: December 2021

AbstractOmnivory is ubiquitous in ecological communities. Yet, we lack a consensus of how plant alternative resources impact the ability of omnivores to suppress prey populations. Previous work suggests that plant alternative resources can increase, decrease, or have no effect on the magnitude of omnivore−prey interactions. This discrepancy may arise from (1) the ability of omnivore populations to respond to plant alternative resources and (2) identity‐specific effects of plant alternative resources. We used a meta‐analysis to examine how omnivore population responses and the identity of plant alternative resources affect (1) omnivore predation rates (mainly reported as per capita predation rate) and (2) omnivore impacts on prey population density. Plant alternative resources reduced omnivore predation rate regardless of identity. The suppression of the predation rate by flowers and flowering plants was magnified when pollen alone was tested as the alternative resource. Surprisingly, plant alternative resource availability reduced prey density, suggesting that omnivore predation increased with plant alternative resources. This discrepancy (plant alternative resources not only decreased omnivore predation rates but also decreased prey density) resulted from experimental differences in the ability of omnivore populations to respond to plant alternative resources. In the presence of plant alternative resources, allowing omnivore population responses decreased prey density, while not allowing population responses increased prey density. Because omnivores commonly suppress prey density in the presence of plant alternative resources when population responses of omnivores are allowed, the effectiveness of biological control may depend upon the availability of such resources and the facilitation of population responses.