bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINKRONISASI PERATURAN PERUNDANG-UNDANGAN KETERBUKAAN INFORMASI PUBLIK DALAM SISTEM INFORMASI ADMINISTRASI PERKARA PENGADILAN AGAMA
Authors: Dzikrullah M. Faried 
Published: September 2021

Pengadilan Agama Kabupaten Malang sebagai salah satu lembaga peradilan yang saat ini sedang mengembangkan implementasi keterbukaan informasi publik, meski pada awal implementasinya sempat menghadapi kendala seiring dengan keterbatasan sumber daya manusia yang berkompeten, disamping karena banyaknya peraturan yang harus diterapkan dalam keterbukaan informasi publik. Karenanya perlu kiranya masing-masing peraturan tersebut dapat diselaraskan dalam implementasinya di melalui sinkronisasi implementasi peraturan perundang-undangan tersebut.Kata kunci: implementasi, sistem informasi, administrasi perkara The Religious Courts of Malang Regency as one of the judiciary institutions that is currently developing the implementation of openness of public information, although at the beginning of its implementation had faced obstacles in line with the limitations of competent human resources, as well as the number of regulations to be applied in public information disclosure. Therefore it is important that each of these regulations can be adjusted in its implementation through the synchronization of the implementation of the laws and regulations.Keywords: implementation, information system, administration of things
IMPLIKASI YURIDIS PENGATURAN KEPUTUSAN TATA USAHA NEGARA FIKTIF POSITIF DAN FIKTIF NEGATIF
Authors: Abrory Makhtum Yandi 
Published: September 2021

Jawaban yang diperoleh penulis dalam penelitian ini yaitu dengan adanya pengaturan di dalam UUPTUN yang berimplikasi permohonan tersebut ditolak dan di dalam UUAP permohonan tersebut diterima dianggap dikabulkan maka berimplikasi tidak adanya kepastian hukum, adanya perluasan makna KTUN, adanya dua hukum acara PTUN, kewenangan PTUN, dan berlakunya mengikatnya KTUN. harmonisasi ketentuan di dalam UUPTUN dan UUPTUN dilakukan dengan cara menggunakan teori preferensi, sehingga yang dapat diberlakukan untuk sebagai dasar pengaturan adalah ketentuan di dalam UUAP. Oleh sebab itu perlu dilakukan legislative refiew untuk merevisi UUPTUN.Kata kunci: KTUN, permohonan, sikap diam The answers obtained by the authors in this study that with the arrangement in UUPTUN implicating the application is rejected and in the UUAP the request is accepted considered granted, it implies the absence of legal certainty, the extension of the meaning of KTUN, the existence of two law of the PTUN event, the authority of PTUN, and the enactment of binding it KTUN. harmonization of provisions in UUPTUN and UUPTUN is done by using the theory of preference, so that which can be applied for the basis of arrangement is provision in UUAP. Therefore, legislative refiew needed to revise the UUPTUN.Keywords: KTUN, petition, silence
Obtaining Cellulose-Available Raw Materials by Pretreatment of Common Agro-Forestry Residues With Pleurotus spp.
Authors: Galić Milica , Stajić Mirjana , Vukojević Jelena , Ćilerdžić Jasmina 
Published: September 2021

The goals of the present study were to characterize the profile of ligninolytic enzymes in fivePleurotusspecies and determine their ability to delignify eight common agro-forestry residues. Generally, corn stalks were the optimal inducer of Mn-dependent peroxidase activity, but the activity peak was noted after wheat straw fermentation byP. eryngii(3066.92 U/L).P.floridawas the best producer of versatile peroxidase, especially on wheat straw (3028.41 U/L), while apple sawdust induced the highest level of laccase activity inP. ostreatus(49601.82 U/L). Efficiency of the studied enzymes was expressed in terms of substrate dry matter loss, which was more substrate-than species-dependent. Reduction of substrate dry mass ranged between 24.83% in wheat straw and 8.83% in plum sawdust as a result of fermentation withP.floridaandP. pulmonarius, respectively. The extent of delignification of the studied substrates was different, ranging from 51.97% after wheat straw fermentation byP.pulmonariusto 4.18% in grapevine sawdust fermented byP. ostreatus.P.pulmonariuswas also characterized by the highest cellulose enrichment (6.54) andP. ostreatusby very low one (1.55). The tested biomass is a highly abundant but underutilized source of numerous value-added products, and a cocktail of ligninolytic enzymes ofPleurotusspp. could be useful for its environmentally and economically friendly transformation.
A TRIZ Approach to Reliable Megaproject Sustainability
Authors: Chen Zhen , Agapiou Andrew , Li Heng , Xu Qian 
Published: September 2021

Purposes: This article presents a recent research into megaproject sustainability with a particular focus on identifying a structure of its body of knowledge so as to establish the methodology of megaproject assessment on sustainability (MAS), which consists of a research roadmap toward megaproject sustainability and a system reliability analysis. In response to the research topic on “Reviews for Advanced Construction Management” at Frontiers in Built Environment, this article aims to make a contribution with the description about a generic approach to conducting literature review based on a whole range of relevant evidence in a systemic way.Methodology: The research described in this article is underpinned by the use of several methods. The nine-square process (NSP) of Theory of Inventive Problem Solving (TRIZ) is the method for facilitating a systemic evidence-based learning (EBL) process to identify further research into MAS. A normal process to establish research roadmap was then introduced to summarize what has been identified as specific research tasks alongside lifecycle processes on megaproject delivery, to which RIBA Plan of Work 2020 was adopted as the prototype. An event tree analysis (ETA) was eventually introduced by incorporating the novel measurements on system reliability to support quantitative MAS in terms of both practices and research.Findings: This article presents several findings from the described research, and these include that the use of NSP led to the formation of a systematic procedure for literature review, a procedure to support MAS, a research roadmap to facilitate efforts to be made for megaproject sustainability, and the feasibility of system reliability analysis to measure the status of sustainability underpinned by research and practices throughout megaproject lifecycle.Implications: The described research provides four modules to foster further research into megaproject sustainability, and these include a TRIZ-based module to facilitate systemic literature review for EBL, a lifecycle process module for MAS, a prototype research roadmap to guide research and development for megaproject sustainability, and an ETA module to support a system reliability analysis in the dynamic process of research and practices toward megaproject sustainability.Value: The research described in this article has made an initial effort to conduct a strategic review, development, analysis, and discussion about tactics for research and development toward megaproject sustainability. Research findings can be used for related research and practices with regard to technical guidance and best practices in megaproject delivery.
Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies
Authors: Ma Chao , Taghour Mohammed S. , Belal Amany , Mehany Ahmed B. M. , Mostafa Naglaa , Nabeeh Ahmed , Eissa Ibrahim H. , Al-Karmalawy Ahmed A. 
Published: September 2021

Guided by the structural optimization principle and the promising anticancer effect of the quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and synthesized. The synthesized compounds were designed to bear the reported pharmacophoric features of the HDAC inhibitors in addition to an extra moiety to occupy the non-used vacant deep pocket of the HDAC receptor. The newly prepared compounds were evaluated for theirin vitroanti-proliferative activities against HepG-2 and HuH-7 liver cancer cell lines. The tested compounds showed promising anti-proliferative activities against both cell lines. The most active ten candidates (6c,6d,6f,6g,6k,6l,7b,8,10h, and12) were further evaluated for their effect on the gene expression levels of Bax as an apoptotic marker and Bcl-2 as an anti-apoptotic one. Moreover, they were evaluated for their ability to inhibit histone deacetylase (HDAC1, HDAC4, and HDAC6) activities. Compound6cachieved the best cytotoxic activities on both HepG-2 and HuH-7 cell lines with IC50values of 1.53 and 3.06 µM, respectively, and also it showed the most inhibitory activities on HDAC1, HDAC4, and HDAC6 with IC50values of 1.76, 1.39, and 3.46 µM, respectively, compared to suberoylanilide hydroxamic acid (SAHA) as a reference drug (IC50= 0.86, 0.97, and 0.93 µM, respectively). Furthermore, it achieved a more characteristic arrest in the growth of cell population of HepG-2 at both G0/G1 and S phases with 1.23-, and 1.18-fold, respectively, compared to that of the control, as determined by cell cycle analysis. Also, compound6cshowed a marked elevation in the AnxV-FITC apoptotic HepG-2 cells percentage in both early and late phases increasing the total apoptosis percentage by 9.98-, and 10.81-fold, respectively, compared to the control. Furthermore, docking studies were carried out to identify the proposed binding mode of the synthesized compounds towards the prospective target (HDAC4).In silicoADMET and toxicity studies revealed that most of the synthesized compounds have accepted profiles of drug-likeness with low toxicity. Finally, an interesting SAR analysis was concluded to help the future design of more potent HDACIs in the future by medicinal chemists.
Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa
Authors: Fraser-Pitt Douglas J. , Dolan Stephen K. , Toledo-Aparicio David , Hunt Jessica G. , Smith Daniel W. , Lacy-Roberts Niamh , Nupe Hewage Piumi Sara , Stoyanova Teodora N. , Manson Erin , McClean Kevin , Inglis Neil F. , Mercer Derry K. , O’Neil Deborah A. 
Published: September 2021

Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less virulent over time, but often adapts to favour persistence in the host with alginate-producing mucoid, slow-growing, and antibiotic resistant phenotypes emerging. Cysteamine is an endogenous aminothiol which has been shown to prevent biofilm formation, reduce phenazine production, and potentiate antibiotic activity against P. aeruginosa, and has been investigated in clinical trials as an adjunct therapy for pulmonary exacerbations of CF. Here we demonstrate (for the first time in a prokaryote) that cysteamine prevents glycine utilisation by P. aeruginosa in common with previously reported activity blocking the glycine cleavage system in human cells. Despite the clear inhibition of glycine metabolism, cysteamine also inhibits hydrogen cyanide (HCN) production by P. aeruginosa, suggesting a direct interference in the regulation of virulence factor synthesis. Cysteamine impaired chemotaxis, lowered pyocyanin, pyoverdine and exopolysaccharide production, and reduced the toxicity of P. aeruginosa secreted factors in a Galleria mellonella infection model. Thus, cysteamine has additional potent anti-virulence properties targeting P. aeruginosa, further supporting its therapeutic potential in CF and other infections.
Comparison of the Direct Oral Anticoagulants and Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Bitar Yasmin de Souza Lima , Duraes Andre Rodrigues , Roever Leonardo , Gomes Neto Mansueto , Lins-Kusterer Liliane , Bocchi Edimar Alcides 
Published: September 2021

Background: Direct oral anticoagulants (DOACS) are approved for use in non-valvular atrial fibrillation (AF). This systematic review and meta-analysis aimed to evaluate the efficacy and safety of DOACs vs. warfarin and update the evidence for treatment of AF and valvular heart disease (VHD).Methods: We identified randomized clinical trials (RCTs) and post-hoc analyses comparing the use of DOACS and Warfarin in AF and VHD, including biological and mechanical heart valves (MHV), updating from 2010 to 2020. Through systematic review and meta-analysis, by using the “Rev Man” program 5.3, the primary effectiveness endpoints were stroke and systemic embolism (SE). The primary safety outcome was major bleeding, while the secondary outcome included intracranial hemorrhage. We performed prespecified subgroup analyses. Data were analyzed by risk ratio (RR) and 95% confidence interval (CI) and the I-square (I2) statistic as a quantitative measure of inconsistency. Risk of bias and methodological quality assessment of included trials was evaluated with the modified Cochrane risk-of-bias tool.Results: We screened 326 articles and included 8 RCTs (n = 14.902). DOACs significantly reduced the risk of stroke/SE (RR 0.80, 95% CI: 0.68–0.94; P = 0.008; moderate quality evidence; I2 = 2%) and intracranial hemorrhage (RR 0.40, 95% CI: 0.24–0.66; P = 0.0004; I2 = 49%) with a similar risk of major bleeding (RR 0.83, 95% CI: 0.56–1.24; P = 0.36; I2 = 88%) compared to Warfarin.Conclusions: In this update, DOACs remained with similar efficacy and safety compared to warfarin in thromboprophylaxis for AF and VHD.
Frozen Embryo Transfer in Mildly Stimulated Cycle With Letrozole Compared to Natural Cycle in Ovulatory Women: A Large Retrospective Study
Authors: Li Danjun , Khor Shuzin , Huang Jialyu , Chen Qiuju , Lyu Qifeng , Cai Renfei , Kuang Yanping , Lu Xuefeng 
Published: September 2021

ObjectiveTo evaluate the clinical effect of mild stimulation with letrozole on pregnancy outcomes in ovulatory women undergoing frozen embryo transfer (FET) compared to natural cycle.DesignRetrospective observational study.SettingTertiary care academic medical center.PopulationA total of 6,874 infertile women with regular menstrual cycles (21-35 days) met the criteria for this study in the period from 2013 to 2020.MethodsAll patients who were prepared for and underwent FET were divided into two groups: a modified natural cycle (NC) group (n=3,958) and a letrozole cycle group (n=2,916).Main Outcome MeasuresThe primary outcome of the study was clinical pregnancy rate. Secondary outcome measures were endometrial thickness, rates of implantation, positive HCG test, live birth, early miscarriage and ectopic pregnancy.ResultsThe clinical pregnancy rate was not statistically different between the modified NC-FET group and the letrozole-FFT group before (crude OR 0.99, 95% CI 0.90-1.09, P=0.902&gt;0.05) and after propensity score matching (PSM) (crude OR 1.01, 95% CI 0.91-1.12, P=0.870&gt;0.05). After multivariable logistic regression analysis, the clinical pregnancy rate remained insignificant before (adjusted OR 1.00, 95% CI 0.91-1.10, P=0.979&gt;0.05) and after matching (adjusted OR 1.00, 95% CI 0.89-1.11, P=0.936&gt;0.05), respectively. Similarly, in the crude and adjusted analysis, the positive HCG test, implantation, live birth and early miscarriage rates were also comparable in the letrozole-FFT group and modified NC-FET group before and after matching. Furthermore, the endometrial thickness of letrozole-FFT group was similar to that of modified NC-FET group with adjusted analysis.ConclusionOur observation suggests that mild stimulation with letrozole could produce similar pregnancy outcomes in ovulatory patients who undergo FET when compared with a natural cycle.
Joint Analysis of Genome-Wide Association Data Reveals No Genetic Correlations Between Low Back Pain and Neurodegenerative Diseases
Authors: Wu Pengfei , Du Bing , Wang Bing , Yin Rui , Lv Xin , Dai Yuliang , Zhang Wan , Xia Kun 
Published: September 2021

Background: We aimed to explore the genetic correlation and bidirectional causal relationships between low back pain (LBP) and three neurodegenerative diseases, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS).Methods: Summary-level statistics were obtained from genome-wide association studies of LBP (n = 177,860), AD (n = 63,926), PD (n = 482,730), and ALS (n = 80,610). We implemented linkage disequilibrium score regression to calculate heritability estimates and genetic correlations. To investigate possible causal associations between LBP and three neurodegenerative diseases, we also conducted a bidirectional two-sample Mendelian randomization (MR) study. Inverse variance-weighted MR was employed as the primary method to generate overall estimates, whereas complementary approaches and sensitivity analyses were conducted to confirm the consistency and robustness of the findings.Results: There was no evidence of genetic correlations between LBP and AD (Rg = −0.033, p = 0.766). MR analyses did not support the causal effect of LBP on AD (OR = 1.031; 95% CI, 0.924–1.150; p = 0.590) or the effect of AD on LBP (OR = 0.963; 95% CI, 0.923–1.006; p = 0.090). Likewise, this study failed to identify genetic correlations between LBP and two other neurodegenerative diseases. MR results of the associations of LBP with PD and ALS, and the reverse associations, did not reach Bonferroni-corrected significance.Conclusion: The study did not support genetic correlations or causations between LBP and three common neurodegenerative diseases, AD, PD, and ALS in the European population.
An Italian Disease-Based Registry of Axial and Peripheral Spondyloarthritis: The SIRENA Study
Authors: Zabotti Alen , Luchetti Michele Maria , Selmi Carlo Francesco , Ramonda Roberta , Grembiale Rosa Daniela , Dagna Lorenzo , D'Angelo Salvatore , Cafaro Giacomo , De Vita Salvatore , Felicetti Mara , Marelli Silvia , Frigerio Daniela , Favalli Ennio Giulio 
Published: September 2021

Introduction: Data about the clinical presentation and management of early and mild spondyloarthritis (SpA) are limited.Objectives: The objective of this study was to describe the baseline characteristics of disease-modifying antirheumatic drug (DMARD)-naïve patients with axial or peripheral SpA.Methods: The Spondyloarthritis Italian Registry: Evidence from a National Pathway (SIRENA) study is an ongoing, Italian, multicenter, prospective registry of patients with a first or newly confirmed diagnosis of SpA according to the Assessment of SpondyloArthritis International Society (ASAS) criteria. To be included, patients had to be naïve to conventional, targeted, and biological DMARDs for SpA. Patients were enrolled between June 2017 and June 2019 and classified into groups according to disease presentation: predominantly axial or peripheral manifestations. The study is ongoing, and patients are being followed for 2 years, with an evaluation every 6 months according to clinical practice. Differences in baseline demographics, lifestyle, and clinical characteristics between axial and peripheral SpA were evaluated.Results: In this study, 350 patients were enrolled, of which 123 (35.1%) were axial and 227 (64.9%) were peripheral patients. Patients with axial SpA were significantly younger at enrollment (median age: 44 vs. 53 years), had significantly more anxiety/depression (13 vs. 2.6%), and expressed higher disease activity compared to patients with peripheral SpA. Patients with peripheral SpA had significantly more cardiometabolic disorders (33 vs. 18.7%), skin psoriasis (65.2 vs. 21.1%), and nail psoriasis (35.5 vs. 17.1%) than patients with axial SpA. Dactylitis, enthesitis, and fibromyalgia were observed, respectively, in 17.6, 51.2, and 5.7% of patients with axial SpA and 24.3, 40, and 3.1% of patients with peripheral SpA. In both disease groups, women tended to report depression, joint tenderness, and higher disease activity more frequently than their male counterparts. At inclusion, a new diagnosis of SpA was performed in 58% of axial and 77% of peripheral patients, with a median time from symptom onset to diagnosis of 36 and 24 months, respectively. At baseline, most patients with axial SpA (77%) started a biological DMARD, while over half of the peripheral patients started a conventional DMARD.Conclusions: Based on a well-characterized clinical registry of SpA, we provided real-world insights on the clinical features of DMARD-naïve SpA patients, pointing out major differences between axial and peripheral disease in terms of clinical characteristics and treatment pattern. Future prospective evaluations within the SIRENA study will improve knowledge on SpA and contribute to defining the best therapeutic approach.
Long-Term Survival Outcomes and Comparison of Different Treatment Modalities for Stage I-III Cervical Esophageal Carcinoma
Authors: Lu Yanwei , Xu Chenwang , Wang Haitao , Song Tao , Wu Shixiu , Liang Xiaodong , Xu Hong'en 
Published: September 2021

Purpose: To investigate the survival outcomes, prognostic factors and treatment modalities of stage I-III cervical esophageal carcinoma (CEC) patients using data from the Surveillance, Epidemiology, and End Results (SEER) database from the period 2004–2016.Methods: Patients with a histopathologic diagnosis of CEC were included. The primary endpoint was overall survival (OS). Univariate and multivariate analyses of OS were performed using Cox proportional hazards models, and OS was compared using the Kaplan-Meier method and log-rank test.Results: A total of 347 patients in the SEER database were enrolled. The median OS was 14.0 months, with a 5-year OS rate of 20.9%. The parameters that were found to significantly correlate with OS in the multivariate analysis were age at diagnosis [P &lt; 0.001, hazard ratio (HR) = 1.832], sex [P &lt; 0.001, HR= 1.867], histology [P = 0.001, HR = 0.366], surgery at the primary site [P = 0.021, HR = 0.553], radiotherapy (RT, P = 0.017, HR = 0.637) and chemotherapy (CT, P &lt; 0.001, HR = 0.444). Comparison among the three treatment modalities demonstrated that a triple therapy regimen consisting of surgery, RT and CT was associated with a longer survival time than the other two treatment modalities before and after propensity score matching (PSM). However, triple therapy showed no significant survival benefit over double therapy (P = 0.496 before PSM and P = 0.184 after PSM).Conclusions: The survival of patients with CEC remains poor. Surgery, RT and CT were all strongly correlated with OS. We recommend a triple therapy regimen for select CEC patients based on the findings of the current study, although this recommendation should be further confirmed by prospective studies with large sample sizes.