bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDA-approved Antitussive Dextromethorphan Enhances Antifibrotic Effectiveness of Pirfenidone in Bleomycin-induced Mice and Patients with Idiopathic Pulmonary Fibrosis
Authors: Liu Nana , Wang Yubao , Huang Jie , Du Yunze , Wei Luqing , Li Dongsheng , Hong Jau-Shyong , Ning Wen , Feng Jing 
Published: August 2021

Abstract
Background: We aimed to investigate whether dextromethorphan (DM), an antitussive agent, could improve the antifibrotic efficacy of pirfenidone in treating idiopathic pulmonary fibrosis, a fatal interstitial lung disease characterized by progressive and irreversible respiratory failure.Methods: A bleomycin-induced mouse pulmonary fibrosis model study and an open-label randomized clinical trial were performed to evaluate the effectiveness of pirfenidone combined with DM.Results: In the animal study, pirfenidone combined with DM protected the mice against bleomycin-induced pulmonary fibrosis with better capabilities than pirfenidone or DM alone, as indicated by lung histologic analysis and hydroxyproline levels. In the clinical study, pirfenidone plus DM markedly mitigated pulmonary function (FEV1 and FVC) decline and ameliorated chest HRCT imaging scores (ground glass opacities and reticulation) of patients with IPF compared with pirfenidone alone at one year after administration. There were no significant differences in adverse reactions between the pirfenidone-DM group and the pirfenidone group.Conclusions: Pirfenidone plus DM may be a better strategy to modify IPF than pirfenidone alone. The efficacy and safety of the combination of pirfenidone and DM for patients with IPF warrants further verification by a double-blind randomized controlled trial (RCT).
Phosphoproteomics of Cold Stress-Responsive Mechanisms in Rhododendron Chrysanthum
Authors: Liu Yunbo , Zhang Ziyao , Fan Hang , Tan Yun , Zhou Xiaofu , Xu Hongwei 
Published: August 2021

Abstract
As an alpine plant，Rhododendron chrysanthum (R. chrysanthum) has evolved cold resistance mechanisms and become a valuable plant resource with the responsive mechanism of cold stress. In my study, we adopt the phosphoproteomic and proteomic analysis combining with physiological measurement to illustrate the responsive mechanism of R. chrysanthum seedling under cold (4℃) stress. After chilling for 12 h, 350 significantly changed proteins and 274 significantly changed phosphoproteins were detected. Clusters of Orthologous Groups（COG）analysis showed that significantly changed proteins and phosphoproteins were mainly involved in signal transduction and energy production and conversion under cold stress. The results indicated photosynthesis was inhibited under cold stress, but cold induced calcium-mediated signaling, reactive oxygen species (ROS) homeostasis and other transcription regulation factors could protect plants from the destruction caused by cold stress. These results provide a detailed insight into the cold stress response and defense mechanisms of R. chrysanthum leaves at the phosphoproteome level.
Opioid-Free Versus Opioid-Based Anesthesia in Pancreatic Surgery
Authors: Stéphane Hublet , Marianne Galland , Julie Navez , Patrizia Loi , Jean Closset , Patrice Forget , Pierre Lafère 
Published: August 2021

Abstract
Background: Opioid-free anesthesia (OFA) is associated with significantly reduced cumulative postoperative morphine consumption and postoperative nausea and vomiting in comparison with opioid-based anesthesia (OBA). Whether OFA is feasible and may improve outcomes in pancreatic surgery remains unclear. Hence, we retrospectively reviewed a consecutive cohort of patients undergoing pancreatic surgery. Methods: Perioperative data from 77 consecutive patients who underwent pancreatic resection under OBA or OFA were included. Patients received either an OBA with intraoperative remifentanil (n=42) or an OFA (n=35) with a combination of continuous infusions of dexmedetomidine, lidocaine, and esketamine. In OBA, patients also received a single bolus of intrathecal morphine. All patients received intraoperative propofol, sevoflurane, dexamethasone, diclofenac, neuromuscular blockade, postoperative continuous wound infiltration, and patient-controlled morphine. The primary outcome was postoperative pain (Numerical Rating Scale, NRS). Opioid consumption within 48h after extubation, length of stay (LOS), adverse events within 90 days, and 30-day mortality were included as secondary outcomes. Episodes of bradycardia and hypotension requiring rescue medication were considered as safety outcomes.Results: Compared to OBA, NRS (3 [2-4] vs 0 [0-2], P<0.001) and opioid consumption (36 [24-52] vs 10 [2-24], P=0.005) were both less in the OFA group. LOS was shorter by 4 days with OFA (14 [7-46] vs 10 [6-16], P<0.001). OFA (P=0.03), postoperative pancreatic fistula (P=0.0002) and delayed gastric emptying (P<0.0001) were identified as only independent factors for LOS. The comprehensive complication index (CCI) was the lowest with OFA (24.9±25.5 vs 14.1±23.4, P=0.03). There were no differences in demographics, operative time, blood loss, bradycardia, vasopressors administration or time to extubation among groups.Conclusions: In this series, OFA during pancreatic resection is feasible and independently associated with a better outcome, in particular pain outcomes. The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay.
Significance of The Neutrophil-To-Lymphocyte Ratio in Predicting the Response of Neoadjuvant Chemotherapy in Osteosarcoma: A Multicenter Retrospective Study
Authors: Haijun Tang , Dehuai Liu , Jili Lu , Juliang He , Shuyu Ji , Shijie Liao , Qingjun Wei , Shenglin Lu , Liu Yun 
Published: August 2021

Abstract
Background

At present, there is no validated predictive factor for early efficacy of neoadjuvant hemotherapy (NACT) in osteosarcoma. The purpose of this study was to investigate the significance of the neutrophil-to-lymphocyte ratio (NLR) in predicting the response of NACT in osteosarcoma.
Methods

Pathological complete response (pCR) was used to assess the efficacy of NACT. Receiver Operating Characteristic (ROC) curve and Youden index (sensitivity + specificity-1) were used to determine the optimal cut-off values of NLR. Univariate and multivariate analyses by logistic regression model were conducted to confirm the independent factors affecting the efficacy of NACT.
Results

The optimal cutoff value of NLR was 2.36 (sensitivity, 80.0%; specificity, 71.3%). Univariate analysis revealed that the smaller tumor volum, lower stage, lower NLR and lower PLR were more likely to achieve pCR. Multivariate analyses confirmed that NLR before treatment was an independent risk factor for pCR. Compared to patients with a high NLR, those with a low NLR showed more than 2-fold higher chance to achieve pCR (OR 2.82, 95% CI 1.36–5.17, p = 0.02).
Conclusion

NLR is a novel and effective factor predicting the response to NACT in osteosarcoma patients. Patients with higher NLR showed a lower percentage of pCR after NACT.
Effect of Plastic Anisotropy and Process Parameters on the Final Geometry of U-shaped Product in Cold Roll Forming
Authors: Poursafar Amin , Saberi Saeid , Tarkesh Rasoul , Vahabi Meisam , Fesharaki Javad Jafari 
Published: August 2021

Abstract
Since the cold roll forming process is currently used in the production of different sections, it is necessary for manufacturers to further improve the quality of these products. Therefore, it is essential to study various factors influencing the production of these products in detail and provide effective solutions to reduce the factors causing defects in such products. This paper investigates the effect of plastic anisotropy and various factors such as strip thickness, the inter distance between stands, web width, and angle increment on the longitudinal bowing and then compares the results with the practical experiments. Accordingly, a model considering the effect of these parameters on the longitudinal bowing of the final section is considered with the accuracy of 88%. The results show that strip thickness and the increment angle at each stand, and the web width have the most influence on the longitudinal bowing, while strip anisotropy and the inter distance has the least effect on bowing.
Unravelling relativistic fermions in Weyl semimetal TaAs by magnetostriction measurements
Authors: Cichorek Tomasz , Bochenek Lukasz , Juraszek Jaroslaw , Sharlai Yurij , Mikitik Grigorii 
Published: August 2021

Abstract
In the topological semimetals, electrons in the vicinity of the Weyl or Dirac nodes behave like massless relativistic fermions that are of interest both for basic research and future electronic applications. Thus far, a detection of these Dirac or Weyl quasiparticles in topological semimetals is often elusive since in these materials, conventional charge carriers exist as well. Here, considering a prototype topological Weyl semimetal TaAs as an example, we show that when the massless quasiparticles reach the ultra-quantum limit, the magnetostriction of the semimetal is appreciably produced by the relativistic fermions. This field-induced expansion of TaAs measured along the [001] direction exhibits a weak dependence on the magnetic-field orientation and is in striking contrast to the magnetostriction measured along the [100] axis. The latter quantity experiences immense changes from large positive to large negative values with minute deviations of the applied field from the [001] direction. Employing a rigid-band approximation, we work out a theory of the magnetostriction for the Weyl semimetals and point out the features of this thermodynamic probe that can serve as hallmarks of the Weyl quasiparticles. Using the theory, we quantitatively describe a part of the obtained experimental data and find a number of the parameters characterizing TaAs. The derived dependence of the Fermi level on the magnetic field should be also relevant to understanding some other field-dependent properties of this topological semimetal, in particular, the negative longitudinal magnetoresistance. Our results illustrate how a magnetostriction may be used to unveil Weyl fermions in topological semimetals with a noncetrosymmetric crystal structure.
Comparison robust data smoothing algorithms with wavelet filter for denoising sonic log signals
Authors: Aftab Saeed , Moghadam Rasoul Hamidzadeh 
Published: August 2021

Abstract
Well logging is an essential approach to making geophysical surveys and petrophysical measurements and plays a key role to interpret downhole conditions. But, well logging signals usually contain noise that distorts results and causes ambiguous interpretations. In this paper, the wavelet filter and robust data smoothing algorithms are tested for denoising synthetic sonic log and field sonic log data. Robust data smoothing algorithms include Gaussian, RLOESS (Robust locally estimating scatterplot smoothing), and RLOWESS (Robust locally weighted scatterplot smoothing) methods. Uniform and normal distribution noise applied to synthetic model and results revealed that the wavelet filter performs better than data smoothing algorithms for denoising uniform distribution noise. However, the RLOESS removed uniform noise acceptably. But, for normal distribution noise, the wavelet filter disrupts and data smoothing algorithms, specifically RLOESS attenuated noise perfectly. Due to the noise nature of field sonic log data, wavelet filter completely disrupts, but data smoothing algorithms removed the noise of field data more efficiently, particularly RLOESS. So, we can express that RLOESS is a perfect algorithm for denoising sonic log signals, regardless of noise nature.
Assessment of NSAIDS as Potential Inhibitors of the Fatty Acid Amide Hydrolase I (FAAH-1) using Three Different Primary Fatty Acid Amide Substrates In Vitro
Authors: Dongdem Julius T. , Helegbe Gideon K. , Opare-Asamoah Kwame , Wezena Cletus A. , Ocloo Augustine 
Published: August 2021

Abstract
Pain relief · remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a promising target for the discovery of drugs to treat pain and inflammation without significant adverse effects. FAAH-1 is the primary enzyme accountable for the degradation of AEA and related fatty acid amides. Studies have revealed that the simultaneous inhibition of COX and FAAH-1 activities produce greater pharmacological efficiency with significantly lowered toxicity and ulcerogenic activity. Recently, the metabolism of endocannabinoids by COX-2 was suggested to be differentially regulated by NSAIDs. We analysed the affinity of ODA, ArDA and SyDA at the FAAH-1 in vitro and investigated the potency of selected NSAIDs on the hydrolysis of endocannabinoid-like molecules (ODA, ArDA and SyDA) by FAAH-1 from rat liver. NSAIDs were initially screened at 500 µM after which those that exhibited greater potency were further analysed over a range of inhibitor concentrations. The substrate affinity of FAAH-1 obtained, increased in a rank order of ODA < ArDA < SyDA with resultant Vmax values in a rank order of ArDA > ODA > SyDA. The selected NSAIDs caused a concentration-dependent inhibition of FAAH-1 activity with sulindac, carprofen and meclofenamate exhibiting the greatest potency. Michaelis-Menten analysis suggested the mode of inhibition of FAAH-1 hydrolysis of both ODA and ArDA by meclofenamate and indomethacin to be non-competitive in nature. Our data therefore suggest potential for study of these compounds as combined FAAH-1-COX inhibitors.
Deciphering the Influence of Multiple Anthropogenic Inputs on Taxonomic and Functional Profiles of the Microbial Communities in Yitong River, Northeast China
Authors: Zhang Ying , Huo Yang , Zhang Zhiruo , Zhu Suiyi , Fan Wei , Wang Xianze , Huo Mingxin 
Published: August 2021

Abstract
We conducted physicochemical parameters analysis, 16S rRNA amplicon sequencing and real-time quantitative polymerase chain reaction to explore the impact of human inputs on the bacterioplankton communities within a tributary of the largest river flowing through a megacity in northeast China. Agriculture largely accounted for the alteration of diversity and functions of the microbial communities. Furthermore, nutrients were significantly declined at the reservoir outlet, and WWTP effluent discharge caused changes in the river microbial community. NH3-N and NO3--N were the main environmental factors that drive the shift of the bacteria community, and rare taxa played a more important role in the response to environmental changes compared with the abundant ones. The occurrence of the human-specific fecal indicator was mostly derived from agriculture, and its increase in relative abundance was observed in the effluent. Thus, our study provides guidance for ecological assessment and management of rivers by revealing the response pattern of river bacterioplankton to multiple types of anthropogenic stressors.
Novel Piston Technique Versus Ilizarov Technique for The Repair of Bone Defect After Lower Limb Infection
Authors: Du Jiafei , Yin Zifei , Cheng Pengfei , Han Pei , Shen Hao 
Published: August 2021

Abstract
Background
We described the use of a novel Piston technique versus Ilizarov technique to compare the effectiveness and complications for the repair of bone defect after lower limb infection.
Patients and methods:
We retrospectively reviewed 41 patients who had been treated at our department for lower extremity bone defects following osteomyelitis. They were 38 males and 3 females with a mean age of 43.41 (range 12 to 69 years). The infected bone defects involved 36 tibias and 5 femurs. Piston technique (PT, group A) was used in 12 patients and Ilizarov technique (IT, group B) in 29 ones. The mean duration of follow-up was 28.50 months (PT) and 29.90 months (IT). The modified Application of Methods of Illizarov (ASAMI) criteria was used to evaluate the bone healing and functional recovery.
Results
Complete eradication of infection and union of docking sites were accomplished well in both groups. The mean external fixator index (EFI) was 42.32 days/cm in group A versus 58.85 days/cm in group B (p < 0.001). The bone outcomes were similar between group A and B (p = 0.558) [excellent (9 vs. 19), good (3 vs.10)]; group A showed better functional outcomes than group B (p < 0.05) [excellent (7 vs. 6), good (4 vs. 12), fair (0 vs. 10) and poor (1 vs. 1)]. Pain was complained most during follow-up and group A had fewer cases of pin tract infection (1 vs. 6), adjacent joint stiffness (3 vs. 8) and delayed healing of the joint (0 vs. 3).
Conclusions
Satisfactory bone healing can be obtained by using both PT and IT, while PT had better functional results, lower EFI and allowed early removal of the external fixation. We have found that this novel Piston technique can improve the comfort of patients, reduce the incidence of complications, and provide a rapid and convenient rehabilitation.
Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
Authors: Kim Jun Yup , Lee Keon-Joo , Kang Jihoon , Kim Beom Joon , Han Moon-Ku , Kang Kyusik , Kye Min-Surk , Park Jong-Moo , Park Tai Hwan , Park Hong-Kyun , Cho Yong-Jin , Hong Keun-Sik , Lee Kyung Bok , Jang Myung Suk , Lee Ji Sung , Lee Juneyoung , Bae Hee-Joon 
Published: August 2021

Abstract
Introduction:
Clinical implications of elevated fasting triglycerides (FTG) and non-fasting triglycerides (NFTG) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients.
Methods
Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24h of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year.
Results
This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all p < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever-smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all p < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles.
Conclusion
The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.
Wear Mechanism of Nomex/PTFE Fiber Reinforced Composites
Authors: Liu Jian , Lu Fei , He Tiantian , Pang Xianjuan , Zhang Yongzhen 
Published: August 2021

Abstract
This paper is aimed at the problems of abnormal tribological damage and fluctuation of tribological performance in the self-lubricating composite serving in heavy load spherical plain bearing in aerospace field. The Nomex/PTFE fiber reinforced composite was used to carry out a reciprocating block on ring tribological test, investigating the tribological performance of the material and its wear evolution. Results show that the influence of oscillating frequency on material wear is obviously higher than that of load under high load condition (more than 90 MPa or 180 kN). Under a certain load and frequency condition, friction temperature is a key factor to affect wear behavior of the material. Friction heat plays a dominant role in the process of worn out failure of the material. Too high friction temperature greatly weakens the friction and wear performance, resulting in material failure in a short time. Thermal fatigue is the main tribological damage mode of the material under the high load and high frequency condition, with local worn out occurred. This finding was also verified by SEM analysis of the worn surface and wear debris.
Association Between Social Support and Postpartum Depression
Authors: Cho Hahyeon , Lee Kyeongmin , Choi Eunji , Cho Ha Na , Park Boyoung , Suh Mina , Rhee Yumie , Choi Kui Son 
Published: August 2021

Abstract
Introduction:
Postpartum depression is common; however, little is known about its relationship to social support and postpartum depression. This study examined the association between them among South Korean women within one year of childbirth.
Methods
This study was based on the 2016 Korean Study of Women’s Health-Related Issues (K-Stori), a cross-sectional survey employing nationally-representative random sampling. Participants were 1,654 postpartum women within a year of giving birth. Chi-square test and logistic regression analysis were conducted to analyze the associations between social support (and other covariates) and postpartum depression.
Results
Among participants, 266 (16.1%) had postpartum depression. Depending on the level of social support, 6.0%, 53.9%, and 40.1% of them had low, moderate, and high social support, respectively. Women with moderate or low social support were more likely to have postpartum depression (OR = 1.78, 95% CI = 1.26–2.53; OR = 2.76, 95% CI = 1.56–4.89). This trend was observed in participants with multiparity, pregnancy loss, obese body image, and employed women.
Conclusion
Social support was associated with a decreased likelihood of postpartum depression, indicating the importance of social support, especially for women with multiparity, pregnancy loss experience, negative body image, and employed women for preventing postpartum depression.