bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMT rs4680 single nucleotide polymorphism, ethnicity, and age are associated with fibromyalgia in women
Authors: Szezerbaty Stheace Kelly Fernandes , Zicarelli Carlos Alexandre Martins , Lima Luana Oliveira de , Perrucini Priscila Daniele Oliveira , Fernandes Karen Barros Parron , Poli-Frederico Regina Célia 
Published: June 2021

To investigate the influence of the catechol-O-methyltransferase enzyme (COMT) single nucleotide polymorphism (SNP) rs4680 (G/A) on fibromyalgia in women. In this observational study of case-control type 29 women with a diagnosis of FM (cases) and 31 healthy non-fibromyalgia women (controls). Sociodemographic and anthropometric data were collected, as well as data relating to Symptom Severity Scale and Generalized Pain Index and peripheral blood samples for DNA extraction; genotypic analyzes were performed by PCR-SSP. We observed that rs4680 AA genotype was more frequently observed in fibromyalgia than controls (p=0.02). The A allele was also more often present in the fibromyalgia participants than in their control peers (p = 0.03). There was a statistically significant association between race and FM sufferers, showing that those of white ethnicity had a 2.05 times greater chance of developing the syndrome than non-white individuals (p=0.03; CI 95% 0.93 – 4.53). A statistically significant correlation between age and FM was observed (rS=0.812, p=0.01). This study demonstrates that white women above the age of 45, who have the AA genotype or A-allele, presents a higher risk of developing FM, showing that this polymorphism of the COMT gene may be one of the risk factors for the fibromyalgia.
Evaluation of Fracture Resistance of Endodontically Treated Maxillary Premolars Restored with Different Restorative Materials - An In Vitro Study
Authors: Maeda Walber , Nascimento Wayne Martins , Coelho Marcelo Santos , Campos Danilo de Luca , Drumond João Paulo , Soares Adriana de Jesus , Frozoni Marcos 
Published: June 2021

Aim: In this study was evaluated the fracture resistance of endodontically treated maxillary premolars restored with different restorative materials. Methods: Sixty maxillary premolars were submitted to the same mesio-occlusal-distal cavity preparation, endodontic treatment and divided into 5 groups (n = 10): Coltosol Group – GCO restored with calcium silicate material; Glass Ionomer Cement Group – GGIC, restored with Maxxion R; Modified Glass Ionomer Cement – GMGIC, restored with Gold Label 2; Composite Group - GC, restored with Z100, and the positive control group (GP) - left unrestored. One group remained intact (n=10) serving as negative control (GN). Samples were subjected to fracture resistance testing by the universal testing machine until fracture occurred and was registered in newtons (N). Fracture pattern was assessed and described as favorable or unfavorable. The results were statistically analyzed by 1-way analysis of variance and the post hoc Tukey test with significant statistical difference at P < 0.05. Results: Higher fracture resistance results were found for GC (1,128.35 ± 249.17), GMGIC (1,250.77 ± 173.29), and GN (1,277.22 ± 433.44) (P < .05). More favorable fractures were observed in the GCO (6), GC (7), and GN (7) (P < .05). Conclusion: Teeth restored with composite and modified GIC presented the same resistance as intact teeth. Teeth restored with Coltosol and GGIC presented similar resistance to unrestored teeth.
Principais bactérias encontradas em uroculturas de pacientes com Infecções do Trato Urinário (ITU) e seu perfil de resistência frente aos antimicrobianos
Authors: Oliveira Mariane Silva , Trindade Gabriela do Nascimento Caldas , Machado Keyla Liana Bezerra , Santos Maria do Carmo Machado , Oliveira Evaldo Hipólito de 
Published: June 2021

Este trabalho teve por objetivo de avaliar a prevalência das principais bactérias encontradas em uroculturas causadoras de ITU em pacientes atendidos em hospitais dos diferentes estados brasileiros, bem como o perfil de resistência e sensibilidade bacteriana a antimicrobianos, por meio da busca em um banco de dados atualizados, promovendo uma revisão do tema proposto. Para realização desse estudo de revisão literária, foi feito uma busca de artigos recentes (até 7 anos da publicação) nos bancos de dados de periódicos eletrônicos Pubmed, Medline, Lilacs e Scielo, com disponibilidade de textos completos para a coleta de dados que contenham as principais bactérias encontradas em uroculturas de pacientes com Infecções do Trato Urinário juntamente aos sua resistência frente aos mais diversos tipos de antibióticos. Incluiu-se artigos publicados entre os anos de 2014 a 2020 e que tratassem sobre as principais bactérias encontradas em uroculturas e seu perfil de resistência frente aos antimicrobianos. Tendo como critérios de exclusão, qualquer artigo que não trate de nenhum dos temas anteriormente citados e que tivessem sido publicados fora do tempo cronológico delimitado. Foram encontradas 4173 uroculturas positivas, sendo o micro-organismo mais frequentemente isolado a Escherichia coli, seguido de Klebsiella pneumoniae, e Proteus mirabilis. Foi possível constatar altos índices de resistência à E. coli para alguns antimicrobianos da primeira escolha para tratamento da ITU, como ampicilina (55,32%) e sulfametoxazol+trimetroprim (34,36%) Esses dados coletados através de uma base de dados atualizada demonstram a necessidade de promovem o conhecimento a cerca dessa infecção a fim de definir uma terapia empírica adequada, criando assim um esquema terapêutico que auxiliará os profissionais da saúde durante o tratamento dos pacientes com ITU.
Crescimento e maturação de frutos de pitaia de polpa branca
Authors: Rangel Junior Ivan Marcos , Magalhães Deniete Soares , Rodrigues Filipe Almendagna , Pasqual Moacir , Pio Leila Aparecida Salles 
Published: June 2021

A pitaia apresenta grande potencial de mercado e processamento. Porém, a falta de conhecimento sobre seu cultivo ainda é uma barreira que impede sua difusão no país. Assim, objetivou-se avaliar as alterações físico-químicas dos frutos de pitaia (Hylocereus undatus) colhidos em diferentes estágios de desenvolvimento bem como determinar o período ideal de colheita. Foram realizadas análises visuais e de caracterização física, físico-química e química em diferentes estádios de desenvolvimento (7, 14, 21, 28, 35 e 42 dias após a antese). As análises foram: massa do fruto, polpa e casca, rendimento, diâmetro longitudinal e transversal, índice de formato, espessura da casca, firmeza da polpa, sólidos solúveis, pH, acidez, ratio, coloração da casca e teor de minerais na polpa dos frutos. De modo geral, observa-se incrementos no comprimento, massa do fruto e polpa, rendimento e sólidos solúveis e reduções na espessura da casca, firmeza e pH da polpa. A coloração da casca muda de tons verde-amarelo em frutos imaturos para vermelho intenso ao amadurecerem. Embora ocorra redução de minerais com o desenvolvimento do fruto, são encontrados teores significativos e importantes para a dieta humana, com destaque para nitrogênio, potássio, cálcio, manganês, ferro e zinco. São observadas mudanças marcantes nas características dos frutos com o desenvolvimento. As máximas de massa do fruto, diâmetros e ratio ocorrem aos 35 dias, enquanto que a massa da polpa, rendimento e sólidos solúveis ocorrem aos 42 dias após antese. O ponto ideal de colheita, levando-se em conta características organolépticas e aspectos visuais é em torno dos 35 dias, quando alcança maturidade fisiológica, porém, aos 42 dias, a polpa do fruto ainda se encontra com qualidade para consumo.
ANALISIS PENGGUNAAN TATA BAHASA DAN PEMEROLEHAN BAHASA KEDUA BAHASA INGGRIS PADA MAHASISWA THAILAND
Authors: Minkhatunnakhriyah Minkhatunnakhriyah , Fahriany Fahriany , Albiansyah Albiansyah 
Published: June 2021

Abstract: This paper aims to determine the types of grammar usage and todescribe the acquisition of English as a second language among Thaistudents. The method used was a qualitative paradigm and the data sourceswere taken from interviews. The interview instrument was used to obtainthe data in the form of English text production, which was used to identifyand to classify the types of grammar elements and information on howinformants acquire the language. This study results in variations in the useof grammar elements namely simple present tense, simple past tense,degree of comparison, noun phrases, and auxiliary verbs. The results of theinterview show that the process of mastery of a second language wasobtained through watching films in English or films with English subtitles,reading novels in English, and listening to English songs. Keywords: English Grammar; Second Language Acquisition; Speaking
GENDER PERSPECTIVES IN KASNONO TRADITIONAL RITUALS SPEECH IN BILOTO VILLAGE, SOUTH CENTRAL TIMOR DISTRICT
Authors: Rafael Agnes Maria Diana , Benu Asti Yunita 
Published: June 2021

The people of South Central Timor District In East Nusa Tenggara are “archaic” people or traditional people who still maintain their life with local cultural patterns from the legacy of their ancestors. In South Central Timor District, to be precised in Biloto Village, there is a traditional ritual which is a ritual that is cultured for the bride. A bride from any clan and from any tribe is married to one of the Timorese men or atoin meto, she is obliged to follow this Kasnono ritual. If the bride doesn't perform the ritual, then all the bad things will overflow the bride and her new family. This study aims to examine the gender perspective contained in Kasnono's traditional speech and ritual stages. The methods used in studying the data is descriptive qualitative method that used interviews and observation. The method of observation is carried out with the aim of obtaining a complete picture of the data regarding real verbal and nonverbal behavior regarding the continuity of the ritual. Meanwhile, based on the results of observations and interviews, although at a glance this ritual is burdensome for women or wives in their married life, the data proved that the women are the core of their household, whose positions are equal to men, that their roles and existence are highly respected and upheld. In the tradition of Biloto village, a granary is a place of honor for all parts of the Timorese community in the village of Biloto. Therefore, by implementing this ritual the wives hold the key to the family's granary, whereas the husband and the other family members are not allowed to enter the barn.. Finally by carrying out the Kasnono traditional ritual, the wife officially becomes the main control to manage everything in the family house and the wife’s position is equal to her husband..
Does Friday-Monday Dance with Harmony?
Authors: Asnawi Said Kelana , Wijaya Chandra , Siagian Dergibson , Alzah Salam Fadillah 
Published: June 2021

This research is about the weekend effect, a combination of Friday and Monday, and its impact on Monday trading volume. It was found that there was no association between Friday return and Monday return. Still, they occur a combination both Friday and Monday negative return was more than combination both Friday and Monday positive return. There are both combinations (Friday and Monday), and price fluctuation has not affected Monday's volume. There is also no difference in characteristics between groups: Friday and Monday negative return and Friday and Monday positive return. Thus, Friday-Monday dances with harmony; the efficient market occurs.
Keywords: Weekend Effect; Trading Volume; Liquidity; Risk-Return; Market Efficient
The Effect of Financial and Non-Financial Indicators on the Profitability of Islamic Commercial Banks in Indonesia
Authors: Mardillasari Rafika , HS Sufyati , Muktiyanto Ali 
Published: June 2021

This study aims to analyze the influence of financial indicators (CAR, FDR, BOPO, NIM, NPF) and non-financial (number of bank offices, market share, GCG, CSR) on profitability that is proxied by Return on Assets (ROA) of Islamic Banks in 2014 -2018. The data source used is secondary data from 2014-2018. Data analysis techniques used are descriptive analysis, multiple linear regression analysis and the classic assumption test. Findings. The results of the study are that CAR does not have a significant negative effect. FDR does not have a significant negative directional effect. BOPO has a significant negative effect. NIM has a positive positive significant effect. NPF has a significant negative effect. The number of bank offices has no significant positive effect. Market share does not have a significant negative directional effect. GCG does not have a significant negative effect. CSR has a significant negative effect. The adjusted R2 value is 73.21% while the remaining 26.79% is influenced by other variables outside the study so the researcher should further add other variables.
Homocysteine Causes Endothelial Dysfunction via Inflammatory Factor-Mediated Activation of Epithelial Sodium Channel (ENaC)
Authors: Liang Chen , Wang Qiu-Shi , Yang Xu , Zhu Di , Sun Yu , Niu Na , Yao Jie , Dong Bi-Han , Jiang Shuai , Tang Liang-Liang , Lou Jie , Yu Chang-Jiang , Shao Qun , Wu Ming-Ming , Zhang Zhi-Ren 
Published: June 2021

BackgroundHyperhomocysteinemia (HHcy) causes cardiovascular diseases via regulating inflammatory responses. We investigated whether and how the epithelial sodium channel (ENaC), a recently identified ion channel in endothelial cells, plays a role in HHcy-induced endothelial dysfunction.MethodsCell-attached patch-clamp recording in acute split-open aortic endothelial cells, western blot, confocal imaging, and wire myograph combined with pharmacological approaches were used to determine whether HHcy-mediated inflammatory signaling leads to endothelial dysfunction via stimulating ENaC.ResultsThe data showed that 4 weeks after L-methionine diet the levels of plasma Hcy were significantly increased and the ENaC was dramatically activated in mouse aortic endothelial cells. Administration of benzamil, a specific ENaC blocker, ameliorated L-methionine diet-induced impairment of endothelium-dependent relaxation (EDR) and reversed Hcy-induced increase in ENaC activity. Pharmacological inhibition of NADPH oxidase, reactive oxygen species (ROS), cyclooxygenase-2 (COX-2)/thromboxane B2 (TXB2), or serum/glucocorticoid regulated kinase 1 (SGK1) effectively attenuated both the Hcy-induced activation of endothelial ENaC and impairment of EDR. Our in vitro data showed that both NADPH oxidase inhibitor and an ROS scavenger reversed Hcy-induced increase in COX-2 expression in human umbilical vein endothelial cells (HUVECs). Moreover, Hcy-induced increase in expression levels of SGK-1, phosphorylated-SGK-1, and phosphorylated neural precursor cell-expressed developmentally downregulated protein 4-2 (p-Nedd4-2) in HUVECs were significantly blunted by a COX-2 inhibitor.ConclusionWe show that Hcy activates endothelial ENaC and subsequently impairs EDR of mouse aorta, via ROS/COX-2-dependent activation of SGK-1/Nedd4-2 signaling. Our study provides a rational that blockade of the endothelial ENaC could be potential method to prevent and/or to treat Hcy-induced cardiovascular disease.
The Safety, Immunogenicity, and Immunopersistence of Hepatitis A Vaccine in HBs-Ag-Positive Participants: A Retrospective Study
Authors: Wang Xiaodan , Luo Jia , Ma Fubao , Kang Guodong , Ding Zhengrong , Pan Yue , Zhao Yujiao , Chen Junying , Feng Kai , Yan Lingmei , Zhang Juan , Li Linhao , Lan Qiangping , Li Daiying , Yang Xiaolei , Li Guoliang , Yang Jingsi , Sun Qiangming 
Published: June 2021

ObjectivesTo compare the safety, immunogenicity, and immune persistence of hepatitis A (HA) vaccines between HBs-Ag-positive and -negative participants.Method9000 participants were enrolled in the phase IV study of live attenuated HA (HA-L) or inactivated HA (HA-I) vaccines. The HBs-Ag-positive subjects were detected and became an independent observation group. Adverse reactions (ARs), geometric mean concentrations (GMCs) and seroconversion rates (SRs) of the vaccines were analyzed at five time points until three years after vaccination. Results: 120 HBs-Ag-positive subjects were screened out, only 1 participant had grade 1 experienced ARs after HA-L injection. Except the time point of two years, the SRs of HBs-Ag-positive group were 100% for both vaccines. The GMCs were not statistically different between HBs-Ag-positive and -negative groups after the HA-L vaccination. The logarithmically transformed GMCs for HBs-Ag-positive and -negative groups were 3.21 mIU/mL (95% CI, 2.03-4.39 mIU/mL) and 2.95 mIU/mL (95% CI, 2.88-3.02 mIU/mL) 28 days after the HA-L vaccination, respectively.ConclusionsBoth HA-L and HA-I vaccines were safe for HBs-Ag-positive participants and may provide an excellent long-term protection against HAV in this study. The results indicated that people positive or negative for HBs-Ag can receive both HA-L and HA-I vaccines (ClinicalTrials.gov number, NCT02601040).
Attenuating the Variability of Lipids Is Beneficial for the Hypertension Management to Reduce the Cardiovascular Morbidity and Mortality in Older Adults
Authors: Dong Yuanli , Liu Xukui , Zhao Yingxin , Chai Qiang , Zhang Hua , Gao Yumei , Liu Zhendong 
Published: June 2021

Objective: To investigate the beneficial of attenuating the variability of lipids to the hypertension management in older adults.Methods: Between April 2008 and November 2010, 1,244 hypertensive patients aged ≥60 years were recruited and randomized into placebo and rosuvastatin groups. Outcomes and inter-visit plasma lipids variability were assessed.Results: Over an average follow-up of 83.5 months, the coefficients of variation (CVs) in total cholesterol (TCHO), triglycerides, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) were significantly lower in the rosuvastatin group than the placebo group (p &lt; 0.05). The risks of composite cardiovascular event, myocardial infarction, coronary revascularization, heart failure, total stroke, ischemic stroke, cardiovascular death, and all-cause death were significantly lower in the rosuvastatin group than the placebo group (all p &lt; 0.05). The differences in the risks were significantly diminished after the CVs for TCHO, triglycerides, HDL-c, and LDL-c were separately included as confounders. One-SD of CVs for TCHO, triglycerides, HDL-c, and LDL-c increment were significantly associated with the risks of composite cardiovascular event, myocardial infarction, heart failure, total stroke, ischemic stroke, cardiovascular death, and all-cause death, respectively (all p &lt; 0.05).Conclusions: Rosuvastatin significantly attenuated the intra-visit variability in lipids and decreased the risk of cardiovascular mortality and morbidity. Controlling the variability of lipids is as important as antihypertensive treatment to reduce the cardiovascular morbidity and mortality in the management of older hypertensive patients.Clinical Trial Registration:ChiCTR.org.cn, ChiCTR-IOR-17013557.
Sinking Diatom Assemblages as a Key Driver for Deep Carbon and Silicon Export in the Scotia Sea (Southern Ocean)
Authors: Zúñiga D. , Sanchez-Vidal A. , Flexas M. M. , Carroll D. , Rufino M. M. , Spreen G. , Calafat A. , Abrantes F. 
Published: June 2021

Physical and biogeochemical processes in the Southern Ocean are fundamental for modulating global climate. In this context, a process-based understanding of how Antarctic diatoms control primary production and carbon export, and hence global-ocean carbon sequestration, has been identified as a scientific priority. Here we use novel sediment trap observations in combination with a data-assimilative ocean biogeochemistry model (ECCO-Darwin) to understand how environmental conditions trigger diatom ecology in the iron-fertilized southern Scotia Sea. We unravel the role of diatoms assemblage in controlling the biogeochemistry of sinking material escaping from the euphotic zone, and discuss the link between changes in upper-ocean environmental conditions and the composition of settling material exported from the surface to 1,000 m depth from March 2012 to January 2013. The combined analysis of in situ observations and model simulation suggests that an anomalous sea-ice episode in early summer 2012–2013 favored (via restratification due to sea-ice melt) an early massive bloom of Corethron pennatum that rapidly sank to depth. This event drove high biogenic silicon to organic carbon export ratios, while modulating the carbon and nitrogen isotopic signals of sinking organic matter reaching the deep ocean. Our findings highlight the role of diatom ecology in modulating silicon vs. carbon sequestration efficiency, a critical factor for determining the stoichiometric relationship of limiting nutrients in the Southern Ocean.
Effect of SGLT2 Inhibitors on Type 2 Diabetes Mellitus With Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials
Authors: Wei Qiong , Xu Xinyue , Guo Li , Li Jia , Li Ling 
Published: June 2021

ObjectiveClinical trials showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors can improve non-alcoholic fatty liver disease (NAFLD). In this work, a meta-analysis of randomized controlled trials was conducted to evaluate the effect of SGLT2 inhibitors on type 2 diabetes mellitus (T2DM) with NAFLD.MethodsPubMed, Embase, Web of Science, and Cochrane Libraries were used for the systematic literature review to determine eligible studies. A randomized effect model was adapted to perform a meta-analysis on these eligible studies to estimate the combined effect sizes. Differences were expressed as the weighted average difference (WMD) of the continuous results and the 95% confidence interval (CI).ResultsTen randomized controlled trials with 573 participants were included. SGLT2 inhibitors significantly reduced the levels of alanine transaminase (WMD -5.36 [95% CI: -8.86, -1.85], p = 0.003) and Aspartate Transaminase (WMD -2.56 [95% CI: -3.83, -1.29], p &lt;0.0001). In terms of body composition, liver proton density fat fraction (WMD -2.20 [95% CI: -3.67, -0.74], p = 0.003), visceral fat mass area (WMD -20.71 [95% CI: -28.19, -13.23], p &lt;0.00001), subcutaneous fat areas (WMD -14.68 [95% CI: -26.96, -2.40], p = 0.02) were also significantly reduced.ConclusionSGLT2 inhibitors can remarkably reduce hepatic enzymes, hepatic fat and improve body composition. Thus, they may become a new treatment option for NAFLD.Systematic Review RegistrationPROSPERO, identifier CRD42020215570.