bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of tuberculosis and TB/HIV co-infection in Dushanbe
Authors: Pirmakhmadzoda B. P. , Tilloeva Z. Kh. , Sharifzoda Kh. S. , Kabirov O. Ya. , Imomnazarova K. A. , Odinaeva S. M. 
Published: March 2021

The objective of the study:to determine the burden of tuberculosis with concurrent HIV infection in Dushanbe and the prevalence of multiple drug resistant tuberculosis, to assess the treatment efficacy of drug susceptible and drug resistant tuberculosis depending on the HIV status of patients.Subjects:A cohort retrospective study was carried out assessing results of examination and treatment of all patients (1,838 people) registered for tuberculosis treatment from 01.06.2016 to 25.12.2019 in Dushanbe.Results.Among new tuberculosis cases, MDR is more often registered in HIV positive patients versus HIV negative patients (OR 2.3, 95% CI 1.1-4.9, p = 0.03). The chances of successful treatment of tuberculosis in HIV negative patients were higher versus HIV positive patients as well as in drug susceptible tuberculosis (OR 4.7, 95% CI 3.1-7.4; p < 0.000) versus drug resistant tuberculosis (OR 2.5, 95% CI 1.1-75.7; p = 0.03). The chances of tuberculosis cure did not differ statistically significantly among patients with different HIV status for both drug resistant and drug susceptible tuberculosis.
On the generalisation of Quatember’s bootstrap
Authors: Żądło Tomasz 
Published: March 2021

Abstract
The problem of the estimation of the design-variance and the design-MSE of different estimators and predictors is considered. Bootstrap algorithms applicable to complex sampling designs are used. A generalisation of the bootstrap procedure studied by Quatember (2014) is proposed. In most of the cases considered in our simulation study it leads to more accurate estimates (or to very similar ones in remaining cases) of the design-MSE and the design-variance compared with the original algorithm and its other counteparts.
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability Utilizing Natural Agents
Authors: Nandi Sisir , Roy Harekrishna , Gummadi Asha , Saxena Anil K. 
Published: March 2021

Background:
By the end of 2019, the sudden outbreak of the novel coronavirus disease
(COVID-19) has become a global threat. It is called COVID-19 because it was caused by the novel
coronavirus (SARS-COV-2) in 2019. A total of 1.9 M deaths and 87.9 M cases have been reported
all over the world, where 49M cases have recovered so far. Scientists are working hard to find chemotherapeutics
and vaccines for COVID-19. Mutations in SARS-CoV-2 have been observed in a
combination of several hazardous stresses, making them more resistant and beneficial. So to break
down the viral system, the disease targets are examined.

Objective:
In today's review, a comprehensive study of spike protein explains the main purpose of
the novel coronavirus and how to prevent the spread of the disease virus cross-transmission from infected
to a healthy person.

Methods:
Covid-19 has already been declared a pandemic by the World Health Organization
(WHO) due to its result in causing death and severe illness globally. SARS-CoV-2 is highly contagious;
however, the intermediate host of the novel coronavirus is not clear. To explore the mechanisms
of disease, one of the viral targets, such as the spike protein that binds to human cells and
causes the disease by altering its genetic structure which is considered along with potential inhibitors.

Results:
It has been shown that the interaction of receptor-binding domain (RBD) protein of
SARS- CoV-2 spike and the angiotensin-converting enzyme 2 (ACE2) host receptor and further replication
of coronavirus spike protein causes its invasion in the host cell. The human Lymphocyte
antigen 6 complex, Locus E (LY6E), inhibits the entry of CoV into host cells by interfering with
the human gene, inducing spike protein-mediated membrane fusion. Some natural formulations
have also been shown to prevent spike protein from binding to the host cell.

Conclusion:
With the development of the LY6E gene activator that can inhibit spike protein-
ACE2-mediated membrane fusion, new opportunities for SARS-CoV-2 treatment may
emerge. Existing antiviral fusion inhibitors and natural compounds targeting spike resistance can
serve as a template for further SARS-CoV-2 drug formulation.
Synthesis and characterisation of iron oxide (Fe3O4) ferrofluid nanoparticles coated by poly (vinyl butyral) with microsphere
Authors: Ganachari Sharanabasava V. , Banapurmath Nagaraj R. , Yaradoddi Jayachandra S. , Patil Veerabhadragouda B. , Yavagal Akshata , Mogre Pradyumna 
Published: March 2021

Objective:
Synthesis of magnetic nano Iron oxide (Fe3O4) ferrofluid nanoparticles using chemical methods and its characterization studies

Method:
Iron oxide (Fe3O4) ferrofluid nanoparticles is synthesized by using the chemical co-precipitation technique, ferric and ferrous salts in the alkaline medium, which is known as Reimer’s procedure.

Results:
Nano iron oxide (Fe3O4) particles have different magnetic properties and different magnetic moments, differentiating macroscopic iron oxide in suspended particles. The ratio of surface to volume increases along with the decrease in atomic size so that the surface properties are essential for using any nano-material. Prepared Fe3O4 nanoparticles were coated with oleic acid (C18H34O2) and polyvinyl butyral((C8H14O2)n), further characterized by Materials characterization techniques (SEM, XRD and FTIR). Magneto-rheological (MR) fluid has been one of the interesting studies the shear stress of PVB coated nano iron with microsphere has approximately the same as of PVB coated nano iron but shows very high shear stress withstanding capacity at 650 s-1 shear rates.

Conclusion:
The permanence of the magnetic colloidal depends on the thermal contribution and the balance between attractive and repulsive interactions.
Significance of Color Spaces and Their Selection for Image Processing:
A Survey
Authors: Ansari Mohd. Aquib , Singh Dushyant Kumar 
Published: March 2021

:
The human visual system is encompassed with three components that help to produce a color sensation. The color display devices use this concept and create their full range of colors by incorporating all three primary color components. Any displayable color can be created with the help of these primaries. This paper comprises the concept of color space, which helps to understand a particular device’s color proficiencies. Since colors are a more robust descriptor, color spaces are considered to play a significant role in representing an image appropriately. The performance of many algorithms depends on the selection of an appropriate color space. There are many kinds of color spaces that can be used in real-time applications. These are RGB, nRGB, HSV, TSL, YCbCr, YUV, YES, CIE-XYZ, CMYK, etc. In this paper, color spaces and their vast classification are described in brief. Apart from these, the characteristics, applicability, limitations, mathematical conversion, and other essential factors are also explained for each color space.
New Perspectives for SARS-CoV-2 Rapid Detection
Authors: Khattabi Latifa , Bouhenna Mustapha Mounir , Sellam Feriel 
Published: March 2021

:
The present paper elucidates the conceivable application of two key molecules in
SARS-CoV-2 detection of suspected infected persons. These molecules were selected on the basis
of the strong interaction between ACE-2 and S protein that allows virus attachment to its host
cells; on the other hand, specific immunocompetant effectors are generated by the human immune
system during the infection. Several testing procedures are already being used to diagnose SARSCoV-
2 infection, particularly the RT-PCR technique. ELISA and LFIA are possible assays for the
employment of shACE-2/ hAc-anti-S (the molecules of interest) as the main agents of the test that
confer dual principal functions (capture and detection). The future diagnostic kits involving
shACE-2 and hAc-anti-S will possibly be highly sensitive with rapid detection in addition to their
advantage of relatively easy conception. They could be largely considered as technically advanced
kits in regards to the current SARS-CoV-2 diagnostic immunoassays.
PENGENDALIAN DEMAM BERDARAH DENGUE DENGAN MENGGUNAKAN MODEL TERINTEGRASI PENGENDALIAN VEKTOR TOTAL BERBASIS MASYARAKAT DAN STICKY AUTOCIDAL MOSQUITO TRAP
Authors: Saepudin Malik , Hermilestari Ani , Supraptono Bambang , Kasjono Heru Subaris 
Published: March 2021

Dengue Hemorrhagic Fever (DHF) is still a health problem in Indonesia, including in West Kalimantan Province. The Integrated Model of Community-Based Total Vector Control (PVTBM) and Sticky Autocidal Mosquito Trap (SAMT) is expected to reduce the density of larvae, so that the incidence of dengue can be reduced to the lowest point in the endemic area of Pontianak. This study analyzed the effects of the PVTBM-SAMT integrated model in controlling dengue vectors in endemic areas of Pontianak City. This type of research is Interrupted time series with a nonequivalent no-treatment control group time series. The sample of this study was 200 houses, consisting of 100 houses in the intervention area and 100 houses in the control area. The results showed a decrease in the mean larval density index in the intervention area, namely; HI was 25%, CI was 11.17%, BI was 38%. Statistical analysis showed that the PVTBM-SAMT integration model had a significant effect on the density of larvae: HI, CI, and BI with p values: 0.049, 0.047, and 0.042. It is recommended that the health office and primary health care be able to apply the PVTBM-SAMT method in controlling DHF vector activities and also in the implementation of surveillance and control of Aedes aegypti vector.
Abstrak
Demam Berdarah Dengue (DBD) masih menjadi masalah kesehatan di Indonesia, termasuk di Provinsi Kalimantan Barat. Aplikasi Model Terpadu Pengendalian Vektor Total Berbasis Masyarakat (PVTBM) dan Sticky Autocidal Mosquito Trap (SAMT) bertujuan menurunkan densitas Larva. Penelitian ini menganalisis efek model terintegrasi PVTBM-SAMT dalam pengendalian vektor DBD di wilayah endemis Kota Pontianak. Jenis penelitian ini adalah eksperimen murni dengan rancangan Interrupted time series with a nonequivalent no-treatment control group time series. Sampel penelitian ini sebanyak 200 rumah, terdiri dari 100 rumah di wilayah intervensi dan 100 rumah di wilayah pembanding. Hasil penelitian menunjukan terjadi penurunan rerata indeks kepadatan larva pada wilayah intervensi yaitu; HI sebesar 25%, CI sebesar 11,17%, BI sebesar 38% dan wilayah pembanding. Analisis statistik terdapat perbedaan densitas larva: HI, CI, dan BI sebelum dan sesudah perlakuan secara signifikan dengan nilai p: 0,049, 0,047, dan 0,042. Dinas kesehatan dan puskesmasisarankan dapat menerapkan metode PVTBM-SAMT dalam kegiatan pengendalian vektor DBD dan juga dalam pelaksanaan surveilans serta pengendalian vektor Aedes aegypti.
Analiza mogućnosti optimizacije putanje alata za pozicionu petoosnu obradu na CNC glodalicama
Authors: Tabaković Slobodan Nedeljko , Varga Čongor 
Published: March 2021

Rad predstavlja analizu mogućnosti optimizacije putanje alata na savremenim petoosnim obradnim centrima za obradu glodanjem u SolidCAM softveru sa podrškom iMachining modula u cilju smanjenja obrade, optimalne upotrebe alata i materijala, a samim tim i puno novca.
Estimation of Total and Lipid Bound Sialic acid in oral leukoplakia and oral squamous cell carcinoma patients
Authors: Archana Sonone  , Alka Hande  , Madhuri Gawande  , Swati Patil  
Published: March 2021

Tumour markers are biochemical substances released through tumour cells. They are considered as the rationale or consequence of the carcinogenesis process. Neoplasms often have an increased concentration of sialic acid on the tumour cell surface and are shed or secreted by some of these cells, which increase the concentration in blood. To determine serum levels of total sialic acid (TSA), lipid-bound sialic acid (LBSA), in patients of oral Leukoplakia (LP) and oral squamous cell carcinoma (OSCC). The study comprises 75 subjects which include 25 cases of LP, 25 cases of OSCC and 25 cases of healthy individuals as control. 10 ml intravenous blood was collected under aseptic condition, and biochemical analysis of total sialic acid and lipid-bound sialic acid was carried out by spectrophotometer. We observed levels of TSA and LBSA significantly increased in LP and OSCC as compared to a healthy control group. The increased level of TSA and LBSA in LP helps to determine the early stage of the disease. Further differentiation in grades of OSCC is also possible by these biochemical markers. Thus serum levels of TAS, LBSA can be used as diagnostic and prognostic markers.
Use of Information Communication Technologies (ICTs) and Academic Achievement of University Students: A Correlational Investigation
Authors: Dur-e-Nayab  , Ghulam Fatima  , Sajida Mah Jabeen  
Published: March 2021

Purpose: This study was conducted to explore the relationship between the use of ICTs and the academic achievement of students at public and private level universities. The objectives of the study were to study the relationship between the use of ICTs and academic achievement of masters’ level students.
Methodology: The population of the study included all the students which are enrolled in master degree programs of all public and private sector universities of the Punjab province. The sample of the study comprised 400 students including 243 females and 157 males. The data was collected by a self-developed questionnaire which was based on the students’ opinions related to the use of ICT. All the 400 students gave their responses on six point likert type questionnaire that had 30 items. A pilot study was conducted for the validation of instrument. The reliability index (Cronbach’s Alpha) was 0.89, which was statistically significant. Data were collected personally from students (both male and female) of two public and two private sector universities. The data gathered from the students were analyzed on SPSS version 22. Pearson correlation coefficient, t-test, ANOVA, mean scores, standard deviation were calculated to find the major results.
Findings: The study found the benefits and uses of ICT in education sector and also explored different ways which may help in teaching learning process using resources of ICTs.
Implications: The policy makers should make such policies which ensure the use of ICT resources in all public and private sector educational institutions.
Prevalence and Determinant of Erectile Dysfunction in Type II Diabetes Mellitus and Healthy Men
Authors: Serwaa Dorcas , Bello Folasade Adenike , Osungbade Kayode O. , Nkansah Charles 
Published: March 2021

Erectile dysfunction is currently a growing health concern and one of the most prevalent sexual dysfunctions in men worldwide. Diabetes mellitus is considered a risk factor for developing ED. Therefore, this SHIM study was designed to assess the prevalence, severity and determinant of erectile dysfunction in type II diabetes mellitus patients and healthy men. This hospital-based cross-sectional study was conducted on 132 diabetic male patients and 66 healthy men at the Nkenkaasu hospital, Offinso North, Ghana between January-June, 2019. A pre-structured questionnaire and patients’ medical records were used to document relevant information. Erectile function was assessed using Sexual health inventory for men questionnaire. Data were analyzed using SPSS version 22.0. Chi-square test, binary and multivariable logistic regression analysis were used appropriately. The mean age of study participants was 57.94 ± 9.79 years. The overall mean score on the SHIM test was 12.42 ± 8.15 (range: 1–25), mean of 9.59±7.83 for the type II diabetics and 18.08±5.39 for non-diabetic men. The total erectile dysfunction (ED) prevalence was 81.8% (95% CI: 0.757, 0.869). ED was common in diabetics (70.4%) compared with healthy men (29.6%). Severe ED was 93.7% and 6.3% in the diabetic and non-diabetic men respectively. Multivariate logistic regression revealed that diabetic men with poor health-related quality of life had 3.48 times likelihood of having ED compared to their non-diabetic counterparts (AOR= 3.48, 95% CI; 1.284, 9.453). Very high erectile dysfunction was observed in our study participants. This is worrisome owing to the profound negative impact of ED on the quality of life and fertility of men. It is recommended that periodic assessment of erectile function should form part of routine diabetes care, focusing attention on the modifiable risk factors in preventing, delaying progression, or reversing established ED in persons. Doi: 10.28991/SciMedJ-2021-0301-4 Full Text: PDF
The Domino Effect-Treatment of Superior Vena Cava Obstruction Triggering Tumor Lysis Syndrome: A Case Report
Authors: Ghosh Suman , TVSVGK Tilak , Somasundaram Venkatesan , Deepti Mutreja 
Published: March 2021

Oncological emergencies present in a multitude of manners-structural, metabolic, hematologic, etc. affecting multiple systems, often. Urgent institution of therapy is often required for a successful outcome. Occasionally, the treatment of one emergency can initiate a related or unrelated emergency, necessitating management of all the complications simultaneously. Superior vena cava obstruction (SVCO) is a medical emergency and most often manifests in patients with a malignant disease process requiring immediate diagnostic evaluation and therapy due to its’ life threatening presentation. The management of the SVCO is usually with chemotherapy, radiotherapy or intervention. In cases of large tumor burden, management of SVCO can trigger other complications. Tumor lysis syndrome is an oncologic emergency, which is characterized by a massive release of intracellular potassium, phosphate, and nucleic acid metabolites into the systemic circulation, which can be life-threatening. We present the case of a T-cell acute lymphoblastic leukemia with superior vena cava syndrome, developing tumor lysis syndrome on instituting definitive chemotherapy in a young patient. Doi: 10.28991/SciMedJ-2021-0301-6 Full Text: PDF
Florence Nightingale’s Nursing and Health Care: The Worldwide Legacy, As Seen on the Bicentenary of Her Birth
Authors: McDonald Lynn 
Published: March 2021

Aim: The aim of this article is to articulate the distinctive features on the Nightingale School of Nursing on the occasion of the 2020 bicentenary of her birth. Design: This is a historical study, based on all the available printed and archival sources of Nightingale’s writing. Methods: The article draws on Nightingale sources (full books, articles, chapters, pamphlets and unpublished letters in more than 200 libraries and archives worldwide) published in The Collected Works of Florence Nightingale, 16 volumes, peer-reviewed; transcriptions are available on its website [1]. Results: Nine key findings are discussed in the article: (1) how different Nightingale’s nursing was from what was called ‘nursing’ at the time; (2) that the central role of training allowed nursing to move from being a women’s profession to being open to all qualified; (3) the evolution of Nightingale nursing as medical science and public health advanced; (4) the academic content in her training; (5) team building in her system; (6) her (often misrepresented) views on germ theory; (7) her late work on preventing cholera; (8) the worldwide influence of her work; (9) her work upgrading workhouse infirmaries and advocacy of what would be later called universal access to health care. Conclusion: Nightingale’s ongoing relevance is evident in many of today’s concerns, such as lack of access to quality health care; the shortage of nurses in the United Kingdom’s National Health Service (and in some other countries) and inadequate wages and salaries of nurses and nurse practitioners; the ongoing dangers in nursing and the need to give nurses a safe working environment (the coronavirus is an extreme example); and inadequate data for health care planning purposes. Doi: 10.28991/SciMedJ-2021-0301-7 Full Text: PDF
Measuring the Quality of the Development Process Academic System with E-GQM Method
Authors: Sarwosri - , Nisa Maidina Choirun , Rochimah Siti , Akbar Rizky Januar , Yuhana Umi Laili 
Published: March 2021

In a software development project, aspects of software quality are fundamental; all stakeholders expect high-quality software. To ensure the quality of software products, it is necessary to ensure the software quality process. A software process is essential to be assessed from their quality. In the software development process, the developer needs guidance in carrying out every aspect of it. The goals to achieve and the procedure to measure for each aspect's goals performance must be determined. One method that can be used is the Extended Goal Question Metric method. This method determines what aspects must be achieved for each development process. A few goals to measure are defined for each aspect. For each goal, one or more goals determine one or more relevant questions. For each question, an appropriate metric is Â determined. The next step is mapping between G to Q and Q to M. The measurement was conducted by calculating the goal value obtained from the metric calculation. From this metric, each goal's value could be obtained, whether it is achieved or not. The tests were carried out on the software process to develop the academic Directorate of Technology and Information System Development of Institut Teknologi Sepuluh Nopember Surabaya, Indonesia. Each goal's value exceeded 0.51 (for a scale of 0-1), which achieved the Software development process's quality. The total average score was 0.889.
FİNANSAL YENİDEN YAPILANDIRMA KANUNUNDAN BEKLENEN EKONOMİK FAYDALAR
Authors: TEPEGÖZ Şükrü Mete , AKBAY Ali Tan 
Published: March 2021

Bankalar ve diğer kredi kuruluşları, kredi verme sürecinde çeşitli değerlendirmelerde bulunurlar. Bir mevzuat çerçevesinde hareket ederek kredi alanlarla kredi ilişkisi içerisine girerler. Ancak zaman zaman (sektörel bozulma, işletmelerden kaynaklanan hatalar, ekonomik darboğaz, salgın vb. gibi nedenlerle kredi verenler ile işletmeler arasındaki kredi ilişkisi bozulabilmektedir. Bu bozulma ekonomik darboğaz, salgın gibi makro nedenlerle olduğunda kredi kuruluşları ile kredi kullanan işletmeler için yapısal önlemler almak gerekir. Bu önlemlerden biri de finansal yeniden yapılandırma olarak karşımıza çıkar.
Bu çalışmada amacımız, sorunlu kredilerin finansal yeniden yapılandırma çerçevesinde ele alınarak ekonomiye geri kazandırılması amacıyla dünyada ve ülkemizde süre gelen çeşitli yaklaşımların (İstanbul, Londra Yaklaşımı gibi) açıklanması ve bu yaklaşımların getirdiklerinin kıyas edilerek yorumlanmasıdır. Çalışmanın diğer amacı ise bu yaklaşımların sonuçlarının yarattığı ekonomik faydaları incelemektir.