bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autism spectrum disorder in architecture perspective: a review of the literature and bibliometric assessment of research indexed in Web of Science
Authors: Moniem Ali Reham , Al-Saleh Deema Faisal , Ansari Khadeeja M N , El-Wakeel Hala A. , Shukri Mai Ibrahim 
Published: October 2021

Purpose: The primary objective of this research paper was to explore the current state-of-the-art research on autism spectrum disorder from a designer's perspective. An increasing number of scholarly publications in this discipline have urged researcher interest in this topic; however, there is still a lack of quantitative analysis. Therefore, this paper aims to analyze global research output on autism spectrum disorder from a designer's perspective during 1992–2021. Methodology: A bibliometric method was employed to analyze the published literature from 1992–2021. 812 papers were downloaded from the Web of Science core collection for analysis focused on annual growth of literature, prolific authors, authorship pattern, productive organizations, countries, international collaboration, literature trends by keyword analysis, and identifying the funding agencies. Various bibliometrics and scientometrics software were used to analyze the data, namely Bibexcel, Biblioshiny, and VOS viewer. Results: There were 812 research papers published in 405 sources during 1992–2021. 2019 was noted as the most productive year (NP=101), and 2014 received the highest number of citations (TC=6634). Researchers preferred to publish as journal articles (NP=538; TC=24922). The University of Toronto, Canada, was identified as a productive institution with 42 publications and 5358 citations. The USA was the leading producing country with 433 publications, and most of the researchers publish their work in the journal "Scientific Reports" (NP=16). The word "autism" (NP=257) and "architecture" (NP=165) were the most frequently used keywords in autism research.
АКТУАЛИЗАЦИЯ ПРОФЕССИОНАЛЬНЫХ КОМПЕТЕНЦИЙ ИННОВАЦИОННОЙ ИНЖЕНЕРНОЙ ДЕЯТЕЛЬНОСТИ
Authors: Levitskaya Irina A. 
Published: October 2021

Цель. Статья посвящена актуализации в условиях цифровизации профессиональных компетенций, связанных с принятием инженерных решений исследовательского характера и внедрению инноваций, а также поиском инновационных творческих решений в инженерной деятельности.
Метод или методология проведения работы. Методология инженерно-технического творчества является одним из эффективных методов креативного инжиниринга. Основу исследования образуют аналитико-синтетические методы работы с научными источниками.
Результаты. Установлено, что инженерно-техническое творчество в условиях цифровой экономики представляет собой инновационную инженерную деятельность, направленную на разработку принципиально новых технических решений на основании известных закономерностей.
Область применения результатов. Результаты исследования могут быть применены в сфере педагогического проектирования и прогнозирования деятельности инженеров цифровой экономике.
ПОДХОДЫ К ИЗУЧЕНИЮ РЕЧИ БИЛИНГВОВ (НА ОСНОВЕ АНАЛИЗА ПСИХОЛИНГВИСТИЧЕСКИХ ИССЛЕДОВАНИЙ ЗАРУБЕЖНЫХ АВТОРОВ)
Authors: Ravi Ranjan 
Published: October 2021

Цель. В статье представлен теоретический обзор подходов зарубежных авторов, изучающих проблему становления и развития речи билингвов. Теоретический анализ зарубежных исследований, с точки зрения психологических аспектов, позволит глубже понять особенности когнитивного развития двуязычных детей (в частности, особенностей их речевого развития).
Метод или методология проведения работы. Основу работы образуют теоретические методы исследования в психологии: метод индукции, сравнения и обобщения.
Результаты работы. В статье проанализированы психолингвистические теории с упором на анализ функционирования именно психических процессов (в частности, речи). Обобщение материалов зарубежных практиков позволит усилить содержание коррекционных и развивающих программ для детей-билингвов, усовершенствовать педагогические технологии обучения иностранному языку, отточить техники развития и формирования познавательных процессов с опорой на психологические основы обучения с использованием методик психологической практики.
Область применения результатов. Результаты исследования могут быть применены в сфере образования и педагогической деятельности, а также в сфере прикладной психологии.
Femtosecond laser line-by-line inscription of apodized fiber Bragg gratings
Authors: He Jun , Chen Ziyong , Xu Xizhen , He Jia , Xu Baijie , Du Bin , Guo Kuikui , Chen Runxiao , Wang Yiping 
Published: October 2021

The reflection spectra of conventional fiber Bragg gratings (FBGs) with uniform index modulation profiles typically have strong sidelobes, which hamper the performance of FBG-based optical filters, fiber lasers, and sensors. Here, we propose and demonstrate a femtosecond laser line-by-line (LbL) scanning technique for fabricating apodized FBGs with suppressed sidelobes. This approach can flexibly achieve various apodized modulation profiles via precise control over the length and/or transverse position of each laser-inscribed index modification track. We theoretically and experimentally studied the influences of the apodization function on the side-mode suppression ratio (SMSR) in the fabricated apodized FBG, and the results show that a maximum SMSR of 20.6 dB was achieved in a Gaussian-apodized FBG. Subsequently, we used this method to fabricate various apodized FBGs, and the SMSRs in these FBGs were reduced effectively. Specifically, a dense-wavelength-division-multiplexed Gaussian-apodized FBG array with a wavelength interval of 1.50 nm was successfully fabricated, and the SMSR in such an array is 14 dB. Moreover, a Gaussian-apodized phase-shifted FBG and chirped FBG were also demonstrated with a high SMSR of 14 and 16 dB, respectively. Therefore, such an apodization method based on a modified femtosecond laser LbL scanning technique is an effective and flexible way to fabricate various FBGs with high SMSRs, which is promising to improve the performance of optical filters, fiber lasers, and sensors.
Parallel emitted silicon nitride nanophotonic phased arrays for two-dimensional beam steering
Authors: Sun Caiming , Yang Lesi , Li Binghui , Shi Wu , Wang Hongjie , Chen Zhenmin , Nie Xiaomin , Deng Shupeng , Ding Ning , Zhang Aidong 
Published: October 2021

In this Letter, a two-dimensional (2D) beam steering on silicon nitride (SiNx) nanophotonic phased arrays from visible to near-infrared wavelengths is reported for the first time, to the best of our knowledge. In order to implement beam steering along the transverse direction for one-dimensional waveguide surface grating arrays, wavelengths from 650 to 980 nm provided by the supercontinuum laser are used to excite the phased array. Then the beams are parallel radiated with steering angles in a sequence of 26.84° to

−

16.54

∘

along the transverse direction, and a continuous line in the far field consisting of parallel emitted spots is produced with a total view angle of 43.38°. Moreover, this continuous far-field line is steered along the longitudinal direction with massive wavelengths simultaneously tuned by phase shifts from

−

π

/

2

to over

+

π

/

2

. This method with massive parallel wavelengths emitted paves a new way for 2D steering on SiNx nanophotonic phased arrays.
Laser cooling of a Yb doped silica fiber by 18 Kelvin from room temperature
Authors: Topper Brian , Peysokhan Mostafa , Albrecht Alexander R. , Flores Angel S. , Kuhn Stefan , Hässner Denny , Hein Sigrun , Hupel Christian , Nold Johannes , Haarlammert Nicoletta , Schreiber Thomas , Sheik-Bahae Mansoor , Mafi Arash 
Published: October 2021

An ytterbium doped silica optical fiber with a core diameter of

900

µ

m

has been cooled by 18.4 K below ambient temperature by pumping with 20 W of 1035 nm light in vacuum. In air, cooling by 3.6 K below ambient was observed with the same 20 W pump. The temperatures were measured with a thermal imaging camera and differential luminescence thermometry. The cooling efficiency is calculated to be

1.2
±
0.1
%

. The core of the fiber was codoped with

A

l

3
+

for an Al to Yb ratio of 6:1, to allow for a larger Yb concentration and enhanced laser cooling.
The estimated health impact of sodium reduction through food reformulation in Australia: A modeling study
Authors: Trieu Kathy , Coyle Daisy H. , Afshin Ashkan , Neal Bruce , Marklund Matti , Wu Jason H. Y. 
Published: October 2021

Background
The Australian Government recently established sodium targets for packaged foods to encourage voluntary reformulation to reduce population sodium consumption and related diseases. We modeled the health impact of Australia’s sodium reformulation targets and additional likely health gains if more ambitious, yet feasible sodium targets had been adopted instead.

Methods and findings
Using comparative risk assessment models, we estimated the averted deaths, incidence, and disability-adjusted life years (DALYs) from cardiovascular disease (CVD), chronic kidney disease (CKD) and stomach cancer after implementation of (a) Australia’s sodium targets (overall and by individual companies); (b) United Kingdom’s targets (that covers more product categories); and (c) an optimistic scenario (sales-weighted 25th percentile sodium content for each food category included in the UK program). We used nationally representative data to estimate pre- and post-intervention sodium intake, and other key data sources from the Global Burden of Disease study. Full compliance with the Australian government’s sodium targets could prevent approximately 510 deaths/year (95% UI, 335 to 757), corresponding to about 1% of CVD, CKD, and stomach cancer deaths, and prevent some 1,920 (1,274 to 2,600) new cases and 7,240 (5,138 to 10,008) DALYs/year attributable to these diseases. Over half (59%) of deaths prevented is attributed to reformulation by 5 market-dominant companies. Compliance with the UK and optimistic scenario could avert approximately an additional 660 (207 to 1,227) and 1,070 (511 to 1,856) deaths/year, respectively, compared to Australia’s targets. The main limitation of this study (like other modeling studies) is that it does not prove that sodium reformulation programs will prevent deaths and disease events; rather, it provides the best quantitative estimates and the corresponding uncertainty of the potential effect of the different programs to guide the design of policies.

Conclusions
There is significant potential to strengthen Australia’s sodium reformulation targets to improve its health impact. Promoting compliance by market-dominant food companies will be critical to achieving the potential health gains.
Exploring the facilitators, barriers, and strategies for self-management in adults living with severe mental illness, with and without long-term conditions: A qualitative evidence synthesis
Authors: Balogun-Katung Abisola , Carswell Claire , Brown Jennifer V. E. , Coventry Peter , Ajjan Ramzi , Alderson Sarah , Bellass Sue , Boehnke Jan R. , Holt Richard , Jacobs Rowena , Kellar Ian , Kitchen Charlotte , Lister Jennie , Peckham Emily , Shiers David , Siddiqi Najma , Wright Judy , Young Ben , Taylor Jo ,   on behalf of the DIAMONDS research team
Published: October 2021

Background
People living with severe mental illness (SMI) have a reduced life expectancy by around 15–20 years, in part due to higher rates of long-term conditions (LTCs) such as diabetes and heart disease. Evidence suggests that people with SMI experience difficulties managing their physical health. Little is known, however, about the barriers, facilitators and strategies for self-management of LTCs for people with SMI.

Aim
To systematically review and synthesise the qualitative evidence exploring facilitators, barriers and strategies for self-management of physical health in adults with SMI, both with and without long-term conditions.

Methods
CINAHL, Conference Proceedings Citation Index- Science, HMIC, Medline, NICE Evidence and PsycInfo were searched to identify qualitative studies that explored barriers, facilitators and strategies for self-management in adults with SMI (with or without co-morbid LTCs). Articles were screened independently by two independent reviewers. Eligible studies were purposively sampled for synthesis according to the richness and relevance of data, and thematically synthesised.

Results
Seventy-four articles met the inclusion criteria for the review; 25 articles, reporting findings from 21 studies, were included in the synthesis. Seven studies focused on co-morbid LTC self-management for people with SMI, with the remaining articles exploring self-management in general. Six analytic themes and 28 sub-themes were identified from the synthesis. The themes included: the burden of SMI; living with co-morbidities; beliefs and attitudes about self-management; support from others for self-management; social and environmental factors; and routine, structure and planning.

Conclusions
The synthesis identified a range of barriers and facilitators to self-management, including the burden of living with SMI, social support, attitudes towards self-management and access to resources. To adequately support people with SMI with co-morbid LTCs, healthcare professionals need to account for how barriers and facilitators to self-management are influenced by SMI, and meet the unique needs of this population.
Effects of cannabis ingestion on endometriosis-associated pelvic pain and related symptoms
Authors: Sinclair Justin , Collett Laura , Abbott Jason , Pate David W. , Sarris Jerome , Armour Mike 
Published: October 2021

BackgroundThe use of cannabis for symptoms of endometriosis was investigated utilising retrospective archival data from Strainprint Technologies Ltd., a Canadian data technology company with a mobile phone application that tracks a range of data including dose, mode of administration, chemovar and their effects on various self-reported outcomes, including pelvic pain.MethodsA retrospective, electronic record-based cohort study of StrainprintTMusers with self-reported endometriosis was conducted. Self-rated cannabis efficacy, defined as a function of initial and final symptom ratings, was investigated across the included symptom clusters of cramps, pelvic pain, gastrointestinal pain, nausea, depression, and low libido. Cannabis dosage form, dose and cannabinoid ratio information was also recorded.ResultsA total number of 252 participants identifying as suffering endometriosis recorded 16193 sessions using cannabis between April 2017 and February 2020. The most common method of ingestion was inhalation (n = 10914, 67.4%), with pain as the most common reported symptom being treated by cannabis (n = 9281, 57.3%). Gastrointestinal symptoms, though a less common reason for cannabis usage (15.2%), had the greatest self-reported improvement after use. Inhaled forms had higher efficacy for pain, while oral forms were superior for mood and gastrointestinal symptoms. Dosage varied across ingestion methods, with a median dose of 9 inhalations (IQR 5 to 11) for inhaled dosage forms and 1 mg/mL (IQR 0.5 to 2) for other ingested dosage forms. The ratio of THC to CBD had a statistically significant, yet clinically small, differential effect on efficacy, depending on method of ingestion.ConclusionsCannabis appears to be effective for pelvic pain, gastrointestinal issues and mood, with effectiveness differing based on method of ingestion. The greater propensity for use of an inhaled dosage delivery may be due to the rapid onset of pain-relieving effects versus the slower onset of oral products. Oral forms appeared to be superior compared to inhaled forms in the less commonly reported mood or gastrointestinal categories. Clinical trials investigating the tolerability and effectiveness of cannabis for endometriosis pain and associated symptoms are urgently required.
Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience
Authors: Stanić Dragana , Grujičić Danica , Pekmezović Tatjana , Bokun Jelena , Popović-Vuković Marija , Janić Dragana , Paripović Lejla , Ilić Vesna , Pudrlja Slović Marija , Ilić Rosanda , Raičević Savo , Sarić Milan , Mišković Ivana , Nidžović Borko , Nikitović Marina 
Published: October 2021

ObjectiveThis study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome.MethodsA detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data.ResultsMean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p<0.001). Survival of the children who underwent gross total resection was longer than the children in whom lesser degrees of resection were achieved (p = 0.015). The extent of the disease is a very important parameter found to be associated with survival. Patients with no evidence of disease after surgery had a mean survival of 123 months, compared with 82 months in patients with local residual disease and 55 months in patients with disseminated disease (p<0.001). By the univariate analysis, factors predicting poor outcome in our series were the presentation of disease with hormonal abnormalities, tumor location, and the extent of the disease, while the factors predicting a better outcome were age at the time of diagnosis, presentation of the disease with neurological deficit, and type of resection. By the multivariate analysis, the extent of the disease remained as the only strong adverse risk factor for survival (HR 2.06; 95% CI = 1.38–3.07; p<0.001).ConclusionsWith an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.
El legado cinematográfico de Bigas Luna, Santiago Fouz Hernández (ed.) (2020)
Authors: Lomas Martínez Santiago 
Published: October 2021

Review of: El legado cinematográfico de Bigas Luna, Santiago Fouz Hernández (ed.) (2020)
Valencia: Tirant Humanidades, 346 pp.,
ISBN 978-8-41815-595-6, p/bk, ISBN 978-8-41815-596-3, e-book, €24.30
Imaginar Iberia: Tiempo, espacio y nación en el siglo XIX en España y Portugal, César Rina Simón (2020)
Authors: Isasi Santiago Pérez 
Published: October 2021

Review of: Imaginar Iberia: Tiempo, espacio y nación en el siglo XIX en España y Portugal, César Rina Simón (2020)
Granada: Comares, 191 pp.,
ISBN 978-8-41369-013-1, p/bk, €19
Are babies of vaccinated Pregnant and lactating mothers with ChAdOx1 AstraZeneca covid vaccine more risk for zinc deficiency and SCID disease.
Authors: Ahmed Amr Kamel Khalil , Elkazzaz Mahmoud 
Published: October 2021

AstraZeneca's covid-19 vaccine demonstrates some concerns regarding its excipients, such as polysorbate 80, which serves as a stabilizer, and EDTA, which serves as a binding agent.
7

ADA is a critical purine metabolic enzyme required for adequate immunological competence. The current study examines the effect of Zn2+ on the maintenance of ADA. After eliminating Zn2+, the protein's crystallographic structure has retained a high degree of order and similarity to the original one, with some alterations limited to the areas surrounding the pocket. However, the protein's stability has been dramatically reduced.
EDTA is a highly effective zinc-chelating agent employed in the investigations of protein interactions. The potential damage of the structure and interactions of zinc-binding proteins by EDTA treatment must be considered. Excess Zn2+ has not returned C/H1 to its normal structure, highlighting the irreversible denaturation induced by the EDTA.
Around 30% of proteins in cells form complexes with metals. Metal ions are essential not just for regulating biological functions but also for stabilizing proteins. (ADA, EC 3.5.4.4) has a molecular mass of 40 kDa and contains a firmly attached zinc ion essential for its activity. The lack of its enzymatic activity leads to malfunction B and T cells, and SCID development
Towards cost-effective and elastic cloud database deployment via memory disaggregation
Authors: Zhang Yingqiang , Ruan Chaoyi , Li Cheng , Yang Xinjun , Cao Wei , Li Feifei , Wang Bo , Fang Jing , Wang Yuhui , Huo Jingze , Bi Chao 
Published: October 2021

It is challenging for cloud-native relational databases to meet the ever-increasing needs of scaling compute and memory resources independently and elastically. The recent emergence of memory disaggregation architecture, relying on high-speed RDMA network, offers opportunities to build cost-effective and elastic cloud-native databases. There exist proposals to let unmodified applications run transparently on disaggregated systems. However, running relational database kernel atop such proposals experiences notable performance degradation and time-consuming failure recovery, offsetting the benefits of disaggregation.
To address these challenges, in this paper, we propose a novel database architecture called LegoBase, which explores the co-design of database kernel and memory disaggregation. It pushes the memory management back to the database layer for bypassing the Linux I/O stack and re-using or designing (remote) memory access optimizations with an understanding of data access patterns. LegoBase further splits the conventional ARIES fault tolerance protocol to independently handle the local and remote memory failures for fast recovery of compute instances. We implemented LegoBase atop MySQL. We compare LegoBase against MySQL running on a standalone machine and the state-of-the-art disaggregation proposal Infiniswap. Our evaluation shows that even with a large fraction of data placed on the remote memory, LegoBase's system performance in terms of throughput (up to 9.41% drop) and P99 latency (up to 11.58% increase) is comparable to the monolithic MySQL setup, and significantly outperforms (1.99x-2.33x, respectively) the deployment of MySQL over Infiniswap. Meanwhile, LegoBase introduces an up to 3.87x and 5.48x speedup of the recovery and warm-up time, respectively, over the monolithic MySQL and MySQL over Infiniswap, when handling failures or planned re-configurations.
Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway
Authors: Li Yugang , Xu Zechuan , Chang Shan 
Published: October 2021

AbstractOsteonecrosis of the femoral head (ONFH) induced by glucocorticoids (GCs) has been considered to be associated with the dysfunction of bone marrow mesenchymal stem cells (BMSCs). Studies have reported that GCs can regulate the normal differentiation of BMSCs. However, the exact mechanism of this regulation remains unclear. In this study, we used methylprednisolone (MPS) to induce BMSCs, and then found that the Hippo signaling pathway was upregulated in a dose-dependent manner compared to that in the control group. In addition, the osteogenic ability of BMSCs was decreased, as evaluated by Alizarin Red S staining analysis and alkaline phosphatase activity assays, accompanied by the downregulated expression of Runx2, osteopontin, and osteocalcin. Additionally, the adipogenic capacity of BMSCs under the MPS conditions was increased, as identified by Oil Red O staining with upregulated triglyceride and PPARγ expression. Moreover, suppression by knockdown of MST1 was found to attenuate the Hippo signaling pathway and adipogenic differentiation, while enhancing osteogenic differentiation. In conclusion, our findings revealed that the Hippo signaling pathway was involved in GC-ONFH by affecting the osteogenic and adipogenic differentiation capacities of BMSCs. Our study could provide a basis for further investigation of the specific function of the Hippo pathway in ONFH.