bluuebunny/crossref_metadata_2025_split huggingface dataset:
Core needle biopsy diagnosis of musculoskeletal tumors at a small regional treatment center and at sarcoma referral centers are equally effective and accurate: a retrospective case series
Authors: McGraw Jessica A. , Wooldridge Adam N. , Brindley George 
Published: September 2021

Background:
Although incisional biopsy (IB) is the gold standard for diagnosing musculoskeletal tumors, core needle biopsy (CNB) is becoming common. Many large sarcoma referral centers have evaluated the accuracy of CNB, but its accuracy at smaller centers is unknown.

Methods:
After IRB approval, a retrospective study of patients undergoing CNB and IB for musculoskeletal tumor diagnosis at Texas Tech University Health Sciences Center from 2006 to 2018 was performed. All patients underwent surgical excision of their tumor. Final pathology was the gold standard for analysis. Biopsy effectiveness and accuracy for determining malignancy and pathology was determined. Complications from biopsies and diagnostic errors were evaluated.

Results:
Efficacy of CNB was 83.1% for bone and 97.7% for soft-tissue tumors; IB was 100% effective. Accuracy of determining malignancy of bone tumors was 89.8% for CNB and 100% for IB, while that for soft-tissue tumors was 92.9% with CNB and 100% with IB. Accuracy of CNB determining pathology of bone tumors was 73.1% for malignant and 42.4% for benign tumors, while IB determined pathology of 100% of malignant and 75% of benign tumors. For soft-tissue tumors, CNB accurately diagnosed 88.9% of malignant and 52% of benign tumors while IB accurately diagnosed 100% of malignant and benign soft-tissue tumors. There were no procedural complications related to biopsy.

Conclusions:
The data in this study show that CNB and IB performed at a small treatment center are effective and accurate for diagnosis of musculoskeletal tumors.

Level of Evidence:
Level IV.
Environmental triggers for connective tissue disease: the case of COVID-19 associated with dermatomyositis-specific autoantibodies
Authors: De Santis Maria , Isailovic Natasa , Motta Francesca , Ricordi Caterina , Ceribelli Angela , Lanza Ezio , Azzolini Elena , Badalamenti Salvatore , Voza Antonio , Selmi Carlo 
Published: September 2021

Purpose of review
The aim of the present review is to analyze the link between autoimmune diseases and environmental factors, in particular severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) as it shares numerous features with the interstitial lung disease associated with connective tissue diseases positive for rare autoantibodies directed at highly specific autoantigens (i.e., MDA5 and RIG1) among the intracellular sensors of SARS-CoV-2 in the innate response against viruses.

Recent findings
As shown in recent publications and in our original data, specific autoantibodies may be functionally relevant to COVID-19 infection. We evaluated sera from 35 hospitalized patients with COVID-19 to identify antinuclear antibodies and autoantibodies directed against specific antigenic targets, and we identified anti-nuclear antibodies (ANA) in 20/35 of patients with COVID-19 (57%), in patients with need for supplemental oxygen (90% vs. 20% in ANA-negative cases; P < 0.0001). In 7/35 COVID-19 sera, we detected anti-MJ/NXP2 (n = 3), anti-RIG1 (n = 2), anti-Scl-70/TOPO1 (n = 1), and anti-MDA5 (n = 1), overall associated with a significantly worse pulmonary involvement at lung computerized tomography scans. Eleven (31%) patients were positive for antibodies against the E2/E3 subunits of mitochondrial pyruvate dehydrogenase complex.

Summary
Viral infections such as COVID-19 are associated with ANA and autoantibodies directed toward antiviral signaling antigens in particular in patients with worse pulmonary involvement.
Cost-analysis of Surgical Intraocular Pressure Management in Glaucoma
Authors: Elhusseiny Abdelrahman M. , Yannuzzi Nicolas A. , Khodeiry Mohamed M. , Lee Richard K. , Smiddy William E. 
Published: September 2021

Précis:
The multiplicity of treatment options for lowering intraocular pressure (IOP) is both a blessing and a challenge. Some attention to cost-analysis might assist in choosing an optimal therapy, especially in a cost-constrained, international setting.

Purpose:
The aim of this study was to quantify and to analyze the relative cost of various glaucoma surgical procedures and selective laser trabeculoplasty surgery per mm Hg IOP reduction ($/mm Hg) since standard cost-utility methods are not well suited to the study of glaucoma which characteristically only claims visual acuity in its end stages.

Methods:
Published glaucoma treatment studies were reviewed to quantitate the reduction of mean IOP and glaucoma medications for a given treatment modality. A US perspective was adopted, using Medicare allowable costs were used to calculate a newly introduced parameter—cost per mm Hg IOP reduction—at 1 year postoperatively.

Results:
The cost per mm Hg IOP reduction after 1 year of treatment ranged from $190/mm Hg for trabeculectomy to $1376/mm Hg for iStent. For reference, the cost of selective later trabeculoplasty surgery was $121/mm Hg. After the first year, cost/mm Hg ranged from $12 to $61/mm Hg.

Conclusions:
Conventional glaucoma surgeries and selective laser trabeculoplasty surgery were the most cost-efficient surgical methods to lower IOP compared with the various minimally invasive glaucoma surgeries options. They may be more appropriate management when cost is an important issue.
Childhood Cancers Misdiagnosed as Tuberculosis in a High Tuberculosis Burden Setting
Authors: van Heerden Jennifer K. , van Zyl Anel , Schaaf Hendrik Simon , Frigati Lisa J. , Goussard Pierre , Rabie Helena 
Published: September 2021

Background:
Tuberculosis (TB) and childhood cancers have overlapping presentations and malignancies may be misdiagnosed as TB in high TB-burden settings.

Methods:
This retrospective study investigated the diagnosis of TB in children with cancer registered in the Tygerberg Hospital Childhood Tumor Registry from 2008 to 2018. We studied children on anti-tuberculosis treatment (ATT) at cancer diagnosis or diagnosed with TB within 1 month of cancer diagnosis. We describe the circumstances and extent of this misdiagnosis, quantify the delay in therapy and document the outcomes of these children.

Results:
Twenty-seven of 539 (5%) children in the registry started ATT before cancer diagnosis. Both pulmonary and extrapulmonary TB complicated the cancer diagnosis. Of the 27 patients on ATT at cancer diagnosis, 22 (81%) had contact with a TB case and in 6 of 12 children (50%) a tuberculin skin test was positive. At cancer diagnosis, 16/27 (59%) children had chest radiograph changes interpreted as TB with 11/27 (41%) regarded as suggestive of TB on expert review. The median diagnostic delay between TB and cancer diagnoses was 25 days (interquartile range 3.5–58). Of 539 children with cancer, 204 (38%) died of cancer, including 18/30 (60%) children on ATT at cancer diagnosis or diagnosed with TB within 1 month of cancer diagnosis (odds ratio 2.6; 95% confidence interval: 1.2–5.4; P = 0.012).

Conclusions:
The clinical and radiologic overlap of TB and cancer causes diagnostic confusion in a significant number of children with cancer and may contribute to increased mortality.
APTA Cross Sections and Academies Recommendations for COVID-19 Core Outcome Measures
Authors: Wells Chris L. , Kegelmeyer Deb , Mayer Kirby P. , Kumble Sowmya , Reilley Anne , Campbell Angela , Martin Rebecca 
Published: September 2021

Purpose:
The novel coronavirus (COVID-19) emerged as a major health concern within the United States in early 2020. Because this is a novel virus, little guidance exists for best practice to evaluate this population within the field of physical therapy.

Methods:
An expert task force appointed by the leadership of 9 different academies or sections of the American Physical Therapy Association was formed to develop recommendations for a set of core outcome measures for individuals with or recovering from COVID-19.

Results:
This perspective provides guidance on a best practice recommendation to physical therapists and researchers regarding the use of core outcome measures for individuals with or recovering from COVID-19. The process for the selection of core measures for this population is presented and discussed.

Conclusions:
Core outcome measures improve the ability to track progress and change across the continuum of care at both the patient and population levels.
The Impact of Physicians’ COVID-19 Pandemic Occupational Experiences on Mental Health
Authors: Schwartz Rebecca M. , McCann-Pineo Molly , Bellehsen Mayer , Singh Vansha , Malhotra Prashant , Rasul Rehana , Corley Samantha S. , Jan Sophia , Parashar Nidhi , George Sonia , Yacht Andrew C. , Young John Q. 
Published: September 2021

Objective:
To examine the association between a number of negative COVID-19 occupational experiences and probable anxiety, depression, and PTSD among physicians.

Methods:
Cross-sectional examination of longitudinal registry data consisting of physician personal and occupational well-being. Multivariable logistic regressions were performed to determine the association between negative COVID-19 experiences and outcomes.

Results:
Of the 620 eligible physicians, approximately half were female (49%), and 71% white with a mean age of 46.51 (SD = 13.28). A one-point increase in negative experience score was associated with a 23% increase in probable anxiety (OR = 1.23, 95% CI: 1.14–1.34), a 23% increase in probable depression (OR = 1.23, 95% CI: 1.13–1.33), and a 41% increase in probable PTSD (OR = 1.41, 95% CI: 1.30–1.52).

Conclusions:
Negative pandemic experiences were strongly associated with adverse mental health outcomes while greater resilience was protective.
Exploring Vestibular/Ocular and Cognitive Dysfunction as Prognostic Factors for Protracted Recovery in Sports-Related Concussion Patients Aged 8 to 12 Years
Authors: Price August M. , Knell Gregory , Caze Todd J. , Abt John P. , Loveland Dustin , Burkhart Scott O. 
Published: September 2021

Objective:
To explore the prognostic ability of the vestibular/ocular motor screening (VOMS), King–Devick (K-D) Test, and C3 Logix Trails A and B to identify protracted recovery from sports-related concussion (SRC) in patients aged 8 to 12 years.

Design:
Retrospective cohort analysis.

Setting:
Specialty pediatric sports concussion clinic.

Participants:
A total of 114 youth athletes aged 8 to 12 years who were diagnosed with an SRC within 7 days of injury.

Independent Variables:
A positive screen on the VOMS, K-D, and C3 Logix Trails A and Trails B. Combined positive screens on multiple tests (ie, 2, 3, or all 4 positive screens of 4 possible).

Main Outcome Measures:
Recovery time in days and protracted recovery (recovery time ≥30-days) were the primary outcomes of interest.

Results:
A positive VOMS screen was associated with 1.31 greater days to SRC recovery (P = 0.02) than a negative VOMS screen. The K-D and C3 Logix tests were not significantly associated with recovery time, nor were any combinations of tests (P > 0.05). The VOMS demonstrated moderate prognostic ability to predict normal recovery (negative predictive value = 80.78% [95% CI = 63.73-90.95]). Overall predictive accuracy of normal versus protracted recovery was strongest when a participant screened positive on all 4 tests (Accuracy = 76.32% [95% CI = 67.45-83.78]).

Conclusions:
The VOMS was associated with overall recovery time and proved to be a useful test to identify those who would experience a normal recovery time. Combining the 4 tests improved the prognostic accuracy of the protocol in predicting protracted versus normal recovery. These findings suggest that combining multiple, varied assessments of cognition and vestibular/ocular functions may better explain factors contributing to protracted recovery.
Rapid On-site Evaluation and Final Cytologic Diagnoses Correlation During Endobronchial Ultrasonography
Authors: Iliaz Sinem , Caglayan Benan , Bulutay Pinar , Armutlu Ayse , Uzel Isil , Ozturk Ayse B. 
Published: September 2021

Background:
The cost-effectiveness and low rate of inadequate sampling with the use of rapid on-site evaluation (ROSE) along with endobronchial ultrasonography (EBUS) is well established. Our aim in this study was to evaluate the correlation of ROSE during EBUS and final cytologic diagnosis and also to see if ROSE might predict the subtype of lung cancer.

Patients and Methods:
All consecutive subjects who attended our clinic between January 2016 and January 2019 for the evaluation of pathologic mediastinal and/or hilar lymph nodes (LNs)/mass using EBUS were enrolled into our prospective study. ROSE was performed in the same operating room with EBUS. ROSE results during EBUS were recorded. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ROSE compared with the final cytologic diagnosis were evaluated.

Results:
We enrolled 684 LN/mass lesions belonging to 328 patients into this study. When we compared ROSE results and final cytologic diagnosis, these procedures agreed on 91.6% of the LNs (P<0.001). The sensitivity of ROSE and final cytologic diagnosis for granulomatous inflammation was 72.5%, and for lung cancer, it was 89.2% (P<0.001). The sensitivity of ROSE for the adenocarcinoma subtype of lung cancer was 67.7%, and it was 70% for small cell lung cancer.

Conclusion:
ROSE may help to recognize non–small cell lung cancer during EBUS, especially the adenocarcinoma subtype of lung cancer, which will help ensure having sufficient material for molecular analysis.
Combination treatment with trastuzumab and crizotinib in metastatic gastric cancer harboring Her-2 amplification and c-MET amplification
Authors: Liu Mingsheng 
Published: September 2021

Abstact

Rationale:
Metastatic gastric cancer patients with poor eastern cooperative oncology group performance status (PS) (≥3) were lack of effective anti-tumor strategies. They always lived with poor PS, severe and multiple symptoms, and usually resulted in extremely limited survival time. Herein, we reported a patient diagnosed with gastric cancer metastasized to multiple bones, along with lymphangitis carcinomatosa in lungs, harboring Her-2 and c-MET amplification with poor PS, positively responded to combinational therapy with trastuzumab and crizotinib.

Patient concerns:
The patient complained of persistent cough and fatigue for 2 months, otherwise, she denied smoking, alcohol history, or any other medical or family history.

Diagnosis:
With the biopsy results from gastroscopy, as well as computer tomography for chest and abdomen, the patient was diagnosed as gastric adenocarcinoma, with metastasis on lungs, left adrenal gland, retroperitoneal lymph nodes, and multiple bones.

Interventions:
Because of the poor PS (PS = 3), as well as Her-2 and c-MET amplification, the patient received combination treatment with trastuzumab and crizotinib as salvage strategy.

Outcomes:
After 2 months’ exposure of trastuzumab and crizotinib, symptoms including persistent cough, and chest distress were alleviated significantly. Simultaneously, chest computer tomography showed significant dissipation of lymphangitis carcinomatosa, as well as apparent reduction of pleural effusion. No adverse reactions including nausea, vomiting, diarrhea, or hypertension was observed during the following 2 months.

Lessons:
The present case suggested that combinational therapy with trastuzumab and crizotinib might be effective in metastatic gastric cancer patients harboring Her-2 and c-MET amplification, even with a poor PS. It was also implied that gene sequencing might be valuable, especially in patients with limited treatment strategies.
Efficacy and safety of acupuncture in the treatment of postherpetic neuralgia
Authors: Zhao Jian , Zhou Zhongguang , He Xin , Yuan Yin , Wang Di 
Published: September 2021

Abstract

Background:
It is simple, convenient, inexpensive, proven, extensive, and safe for acupuncture in the treatment of postherpetic neuralgia (PHN). However, there are no comparisons between various acupuncture therapies that can directly and effectively provide specific guidance to clinicians. The development of a guideline for the optimization of acupuncture for PHN is of great importance for the development of clinical acupuncture. Therefore, we attempted to design a study protocol for a network meta-analysis of randomized controlled trials of acupuncture for PHN to provide evidence to support the treatment of acupuncture for PHN.

Methods:
A search of 8 databases, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Wanfang, China Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science, was conducted to collect randomized controlled trials about acupuncture for PHN. RevMan 5.3 and Stata 14.0 software were used for data analysis.

Results:
This meta-analysis will provide additional and more robust evidence for acupuncture treatment of PHN. Our findings will assist clinicians in making treatment decisions.

Conclusion:
This study will provide comprehensive and reliable evidence-based evidence for the treatment of PHN with acupuncture.
The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression
Authors: Grypari Ioanna Maria , Logotheti Souzana , Zolota Vasiliki , Troncoso Patricia , Efstathiou Eleni , Bravou Vasiliki , Melachrinou Maria , Logothetis Christopher , Tzelepi Vasiliki 
Published: September 2021

Abstract
Epigenetic changes are implicated in prostate cancer (PCa) progression and resistance to therapy. Arginine residue methylation is an understudied histone post-translational modification that is increasingly associated with cancer progression and is catalyzed by enzymes called protein arginine methyltransferases (PRMTs). The molecular consequences of aberrant expression of PRMTs in PCa and the relationship between PRMTs and PCa progression are largely unknown. Using immunohistochemistry, we examined the expression of PRMT1 and CARM1, two of the best-studied PRMTs, in 288 patients across the spectrum of PCa and correlated them with markers of androgen receptor (AR) signaling, and milestones of carcinogenesis. Our findings indicate that PRMT1 and CARM1 are upregulated early in PCa progression, and that CARM1 is further upregulated after therapy. In addition, a correlation of CARM1 with AR post-translational modifications was noted in the setting of therapy resistance, highlighting CARM1 as one of the adaptation mechanisms of PCa cells in an androgen-depleted environment. Finally, CARM1 correlated with markers of cell cycle regulation, and both CARM1 and PRMT1 correlated with markers of epithelial-to-mesenchymal transition signaling. Taken together these findings indicate that an epigenetic network drives PCa progression through enhancement of milestone pathways including AR signaling, the cell cycle, and epithelial-to-mesenchymal transition.
COVID-19 related discrimination in Japan
Authors: Suzuki Reina , Iizuka Yusuke , Lefor Alan Kawarai 
Published: September 2021

Abstract
To assess the general Japanese population's thoughts on coronavirus disease of 2019 related discrimination by Tweets.
Tweets were retrieved from search queries using the keywords “health care providers and discrimination (no hashtags)” and “corona and rural area (no hashtags)” via the Twitter application programming interface. Subsequently, a text-mining analysis was conducted on tokenized text data. R version 4.0.2 was used for the analysis.
In total, 51,906 tweets for “corona and health care providers”, 59,560 tweets for “corona and rural” were obtained between the search period of July 29, 2020 and September 30, 2020. The most common 20 words from the tokenized text data were translated to English. Word clouds with the original Japanese words are presented.
Tweets for corona and health care providers did not suggest significant evidence of discrimination toward health care providers on Twitter. Results for corona and rural area, however, showed the unexpected word “murahachibu” (an outmoded word meaning ostracism), suggesting persistent strong social pressure to prevent bringing the disease to the community. This kind of pressure may not be supported by scientific facts. These results demonstrate the need for continued educational efforts to disseminate factual information to the public.
Determinants of prognosis in geriatric patients followed in respiratory ICU; either infection or malnutrition
Authors: Eraslan Doganay Guler , Cirik Mustafa Ozgur 
Published: September 2021

Abstract
Severity of illness, age, malnutrition, and infection are the important factors determining intensive care unit (ICU) survival.
The aim of the study is to determine the relations between Geriatric Nutritional Risk Index (GNRI), C-reactive protein/albumin (CAR), and prognosis-mortality of geriatric patients (age of ≥65 years) admitted to intensive care unit.
The study with 10/15/2020, 697 approval date, and number retrospectively registered. Between January 1, 2018 and December 31, 2019, 413 geriatric patients admitted to ICU. The patients were divided into three groups according to their age.
The age group, gender, Charlson comorbidity index, intensive care scores (Acute Physiology And Chronic Health Evaluation II and Sequential Organ Failure Assessment), the infection markers (white blood cell, procalcitonin, CAR levels), malnutrition tools for each patient (body mass index, Nutrition Risk in Critically ill score, and GNRI scores) were analyzed retrospectively. Also length of stay (LOS) ICU, length of stay hospital, and 30-day mortality were recorded.
Geriatric patients number of 403 was included in the study. Forty-nine (12.3%) patients had a history of malignancy, 272 (67.5%) patients had Chronic Obstructive Pulmonary Disease comorbidity. There was no difference in mortality between age groups.
In patients with mortality, body mass index, had being Chronic Obstructive Pulmonary Disease history, GNRI, length of stay hospital, and albumin were significantly lower; malignancy comorbidity rate, inotrope use, modified Nutrition Risk in Critically ill score, mechanical ventilation duration, LOS ICU, Sequential Organ Failure Assessment, Acute Physiology And Chronic Health Evaluation II, Charlson comorbidity index, C-reactive protein, procalcitonin, and CAR were significantly higher.
Both malnutrition and infection affect mortality in geriatric patients in intensive care. The GNRI is better than CAR at predicting mortality.
Usefulness of 123I-BMIPP and 201TlCl nuclide scintigraphy in evaluation of myocarditis in patients with polymyositis or dermatomyositis
Authors: Okada Yukinori , Takakuwa Yukiko , Ooka Seido , Ogawa Yukihisa , Kawahata Kumito , Kobayashi Yasuyuki , Yamaguchi Keiichiro , Akashi Yoshihiro 
Published: September 2021

Abstract
To investigate the usefulness of 123I-BMIPP/201TlCl scintigraphy for evaluating the presence of myocarditis in patients with polymyositis (PM) or dermatomyositis (DM).
We performed a retrospective study of 26 patients diagnosed with new-onset active PM/DM who underwent 123I-BMIPP/201TlCl scintigraphy between 01 April 2010 and 20 March 2015. We determined the 123I-BMIPP/201TlCl ratio and grouped the patients according to presence or absence of a mismatch. We evaluated the relationship between mismatch and the laboratory and echocardiographic findings.
Mismatch was found in 13 (50%) patients. There was no statistically significant difference in age, cardiac troponin T, myoglobin, myosin light chain, aldolase levels, E wave/A wave ratio, right ventricular systolic pressure between the mismatch and non-mismatch groups. Left ventricular end-diastolic and end-systolic dimensions were significantly greater in the mismatch group (45.0 vs 42.5 mm, P =  < .01 and 29.5 mm vs 25.0 mm, P < .01). Left ventricular ejection fraction was significantly lower in the mismatch group (63.5% vs 71.5%, P = .04). Significant inverse correlation (r = −0.44, P = .03) was observed between left ventricular ejection fraction and mismatch ratio.
The use of 123I-BMIPP/ 201TlCl scintigraphy may be considered for evaluating myocarditis in patients with PM/DM.