bluuebunny/crossref_metadata_2025_split huggingface dataset:
National trends in the prevalence of diabetic retinopathy among Thai patients with type 2 diabetes and its associated factors from 2014 to 2018
Authors: Euswas Nathakamol , Phonnopparat Napat , Morasert Kantapat , Thakhampaeng Pongpisut , Kaewsanit Apisit , Mungthin Mathirut , Rangsin Ram , Sakboonyarat Boonsub 
Published: January 2021

Introduction
Diabetic retinopathy (DR) is one of the most common and serious ocular complications in both developed and developing countries. To date, epidemiological data of DR and their associated factors in Southeast Asian countries especially in Thailand are scarce. We aimed to use the information from the Thailand Diabetes Mellitus/Hypertension (DM/HT) study to determine trends in DR prevalence and also risk factors among Thai patients with type 2 diabetes (T2D).

Methods
A series of cross-sectional surveys of clinical outcomes was conducted annually in 2014, 2015 and 2018 among patients with T2D aged >18 years receiving medical care for at least 12 months. A stratified single stage cluster sampling method that was proportional to the size sampling technique was used to select a nationally and provincially representative sample of patients with T2D in Thailand. A standardized case report form was used to obtain the required information from medical records.

Results
A total of 104,472 Thai patients with T2D were included in the study from 2014 to 2018. The dominant proportion of participants, 70,756 (67.7%), were females. The overall prevalence of DR declined from 6.9% in 2014 to 6.3% in 2015 and 5.0% in 2018 (p for trend <0.001). The independent associated factors with DR included survey year, greater duration of DM, geographic region, hospital level, social security scheme, dyslipidemia, insulin therapy, high HbA1c level and elevated pulse pressure.

Conclusion
We reported a decreasing in trend in the prevalence of DR among Thai patients with T2D over one half decade. Patients with T2D should be encouraged to control their underlying diseases and engage in other effective interventions. When these modifiable risk factors can be inhibited, DR and other cardiovascular complications will be alleviated.
Text messaging as a tool to improve cancer screening programs (M-TICS Study): A randomized controlled trial protocol
Authors: Vives Nuria , Farre Albert , Ibáñez-Sanz Gemma , Vidal Carmen , Binefa Gemma , Milà Núria , Pérez-Lacasta Maria Jose , Travier Noemie , Benito Llucia , Espinàs Josep Alfons , Bagaria Guillermo , Garcia Montse 
Published: January 2021

Background
Short message service (SMS) based interventions are widely used in healthcare and have shown promising results to improve cancer screening programs. However, more research is still needed to implement SMS in the screening process. We present a study protocol to assess the impact on health and economics of three targeted SMS-based interventions in population-based cancer screening programs.

Methods/Design
The M-TICs study is a randomized controlled trial with a formal process evaluation. Participants aged 50–69 years identified as eligible from the colorectal cancer (CRC) and breast cancer (BC) screening program of the Catalan Institute of Oncology (Catalonia, Spain) will be randomly assigned to receive standard invitation procedure (control group) or SMS-based intervention to promote participation. Two interventions will be conducted in the CRC screening program: 1) Screening invitation reminder: Those who do not participate in the CRC screening within 6 weeks of invite will receive a reminder (SMS or letter); 2) Reminder to complete and return fecal immunochemical test (FIT) kit: SMS reminder versus no intervention to individuals who have picked up a FIT kit at the pharmacy and they have not returned it after 14 days. The third intervention will be performed in the BC screening program. Women who had been screened previously will receive an SMS invitation or a letter invitation to participate in the screening.
As a primary objective we will assess the impact on participation for each intervention. The secondary objectives will be to analyze the cost-effectiveness of the interventions and to assess participants’ perceptions.

Expected results
The results from this randomized controlled trial will provide important empirical evidence for the use of mobile phone technology as a tool for improving population-based cancer screening programs. These results may influence the cancer screening invitation procedure in future routine practice.

Trial registration
Registry: NCT04343950 (04/09/2020); clinicaltrials.gov.
Drug use for gastrointestinal symptoms during pregnancy: A French nationwide study 2010–2018
Authors: Meyer Antoine , Fermaut Marion , Drouin Jérôme , Carbonnel Franck , Weill Alain 
Published: January 2021

Purpose
To describe drug prescription for gastrointestinal symptoms during pregnancy.

Methods
Using the French national health database, we identified pregnancies ending with a birth between April 2010 and December 2018, in France. We studied prescription of antacids, antispasmodics, antinauseants, laxatives and antidiarrheals during pregnancy, between two trimesters before and two trimesters after delivery. We also assessed hospitalization for gastrointestinal symptoms during pregnancy.

Results
Among 6,365,471 pregnancies, 4,452,779 (74.0%) received at least one gastrointestinal drug during pregnancy; 2,228,275 (37.0%) received an antacid, 3,096,858 (51.5%) an antispasmodic, 1,861,731 (31.0%) an antinauseant, 919,116 (15.3%) a laxative and 617,808 (10.3%) an antidiarrheal. Prescription of proton pump inhibitors doubled from 12.2% in 2010 to 26.0% in 2018, while domperidone use decreased from 18.3% in 2010 to 2.2% in 2018. In addition, prescription of antacids increased from 7.0% during the trimester before pregnancy to 11.8% during the 1st trimester, 17.0% during the 2nd trimester and 23.4% during the 3rd trimester. Antispasmodic use was 10.6% during the trimester before pregnancy, 23.1% during the 1st trimester, 25.2% during the 2nd trimester and 24.0% during the 3rd trimester. Prescription of antinauseant drugs increased from 5.0% during the trimester before pregnancy to 25.7% during the 1st trimester, then decreased to 6.4% during the 2nd trimester and 3.2% during the 3rd trimester. Nausea/vomiting was the most common cause of hospitalization for gastrointestinal symptoms or diseases during pregnancy, although it accounted for only 1.0% of pregnancies.

Conclusions
Approximately three-quarters of women use drugs for gastrointestinal symptoms during pregnancy in France. Prescription of gastrointestinal drugs during pregnancy should be the subject of more detailed risk-benefit assessment and recommendations.
Re-evaluation of gestational age as a predictor for subsequent preterm birth
Authors: Pereira Elizabeth , Tessema Gizachew , Gissler Mika , Regan Annette K. , Pereira Gavin 
Published: January 2021

Background
To evaluate gestational age as a predictor of subsequent preterm birth.

Materials and methods
This was a retrospective birth cohort study to evaluate gestational age as a predictor of subsequent preterm birth. Participants were mothers who gave birth to their first two children in Western Australia, 1980–2015 (N = 255,151 mothers). For each week of final gestational age of the first birth, we calculated relative risks (RR) and absolute risks (AR) of subsequent preterm birth defined as final gestational age before 28, 32, 34 and <37 weeks. Risks were unadjusted to preserve risk factor profiles at each week of gestation.

Results
The relative risks of second birth before 28, 32, and 34 weeks’ gestation were all approximately twenty times higher for mothers whose first birth had a gestational age of 22 to 30 weeks compared to those whose first birth was at 40 weeks’ gestation. The absolute risks of second birth before 28, 32, and 34 weeks’ gestation for these mothers had upper confidence limits that were all less than 16.74%. The absolute risk of second birth before 37 weeks was highest at 32.11% (95% CI: 30.27, 34.02) for mothers whose first birth was 22 to 30 weeks’ gestation. For all gestational ages of the first child, the lowest quartile and median gestational age of the second birth were at least 36 weeks and at least 38 weeks, respectively. Sensitivity and positive predictive values were all below 35%.

Conclusion
Relative risks of early subsequent birth increased markedly with decreasing gestational age of the first birth. However, absolute risks of clinically significant preterm birth (<28 weeks, <32 weeks, <34 weeks), sensitivity and positive predictive values remained low. Early gestational age is a strong risk factor but a poor predictor of subsequent preterm birth.
The relationship between released soluble FceRI-alpha and its cell surface density on human basophils
Authors: MacGlashan Donald 
Published: January 2021

BackgroundThe IgE-mediated activation of mast cells and basophils results in the secretion of many substances, including the release of FceRI-alpha subunit. This released alpha subunit can bind IgE and it may act as a down-regulator of subsequent IgE-dependent reactions. However, previous studies do not observe loss of the mass of FceRI-alpha associated with the cells, at least not for human basophils. This study was designed to understand the basis for the discordant observations.MethodsPurified human basophils were stimulated with multiple activating secretagogues and supernatants were examined for histamine and released FceRI-alpha. In addition, cell surface IgE densities (occupied and unoccupied) were measured by flow cytometry and total cellular content of mature and immature FceRI-alpha determined with Western blots.ResultsReleased FceRI-alpha, on average, represented 7% of the total surface FceRI before the reaction. The molecular weight of the soluble FceRI-alpha was approximately 54 kD, larger than immature subunit and somewhat smaller than surface subunit. In addition, 1) release ceased long before internalized FceRI-alpha was processed, 2) release was insensitive to Bafilomycin A, 3) release was independent of the starting density of FceRI and 4) release occurred more effectively with non-IgE-dependent stimuli, FMLP or C5a.ConclusionsThere appears to be relatively constant amount of nearly mature FceRI-alpha that is susceptible to secretion events induced by any form of stimulation. The amount, on average, represents about 7% of the mature form of FceRI-alpha.
Determinants of preterm survival in a tertiary hospital in Ghana: A ten-year review
Authors: Agbeno Evans Kofi , Osarfo Joseph , Ashong Joyce , Anane-Fenin Betty , Okai Emmanuel , Ofori Anthony Amanfo , Aliyu Mohammed , Opoku Douglas Aninng , Ken-Amoah Sebastian , Ashong Joycelyn A. , Soltani Hora 
Published: January 2021

Background
Prematurity (gestational age <37 completed weeks) accounts for the majority of neonatal deaths worldwide and most of these occur in the low-resource countries. Understanding factors that determine the best chances of preterm survival is imperative in order to enhance the care of neonates and reduce adverse outcomes in such complicated births.

Aim
This was to find out the proportions of preterm babies who survived at the Special Care Baby Unit (SCBU) in the Cape Coast Teaching Hospital (CCTH) and the factors which influenced their survival.

Method
This was a retrospective review of data on all the live preterm babies seen at the SCBU of CCTH from 2010 to 2019. Data on 2,254 babies that met the inclusion criteria were extracted. Descriptive statistics were generated and tests of association done with chi-square and multivariable logistic regression.

Outcome
The main outcome measure was the proportion of live preterm neonates who were discharged after SCBU admissions.

Results
The CCTH had a total of 27,320 deliveries from 2010 to 2019. Of these, 1,282 were live preterm births, giving a prevalence of live preterm babies over the ten-year period of 4.7% (1,282/27,320). An increasing trend in prevalence was observed with 2019 recording the highest at 9% (271/3027). Most (48.8%) of the deliveries were vaginal, 39.2% were by caesarean section (CS); the mode of birth for 12% of the women were not documented. The mean gestational age was 31.8 (±2.77) weeks. Of the birth weights documented, <1000g babies accounted for 11.9%, 1000–1499g babies made up 34.8%, while 1500g to 2499g babies accounted for 42.6%. The babies with weights >2500g made up only 3.7%. The average length of hospital stay was 8.3 (±9.88) days. Regarding the main outcome variable, 67.6% were discharged alive, 27.6% died and 4.9% were unaccounted for due to incomplete documentation. Factors which influenced survival were: birth weight (p <0.001); gestational age (p <0.001); mode and place of delivery (p <0.001 for both); APGAR scores at 1st and 5th minutes (p <0.001); and length of stay at the SCBU (p <0.001). No association was found for sex of the baby, maternal age and parity.

Conclusion
This study shows the possibility of achieving good preterm survival rates through the provision of specialised neonatal care, even in resource-constrained countries. This provides an updated benchmark for clinical decision-making and antenatal counselling. It also highlights the problem of inadequate data capture in our part of the world, which needs considerable improvement.
Predictors of adherence to COVID-19 prevention measure among communities in North Shoa Zone, Ethiopia based on health belief model: A cross-sectional study
Authors: Shewasinad Yehualashet Sisay , Asefa Kokebe Kefelegn , Mekonnen Alemayehu Gonie , Gemeda Belete Negess , Shiferaw Wondimenh Shibabaw , Aynalem Yared Asmare , Bilchut Awraris Hailu , Derseh Behailu Tariku , Mekuria Abinet Dagnaw , Mekonnen Wassie Negash , Meseret Wondesen Asegidew , Tegegnework Sisay Shine , Abosetegn Akine Eshete 
Published: January 2021

IntroductionCoronavirus disease 2019 (COVID-19) is an emerging respiratory infections and is known to cause illness ranging from the common cold to severe acute respiratory syndrome. At present, the disease has been posing a serious threat to the communities, and it is critical to know the communities’ level of adherence on COVID-19 prevention measures. Thus, this study aimed to identify the predictors of adherence to COVID-19 prevention measure among communities in North Shoa zone, Ethiopia by using a health belief model.MethodsCommunity-based cross-sectional study design was employed. A total of 683 respondents were interviewed using a structured and pre-tested questionnaire. The data were collected by using a mobile-based application called “Google form.” Logistic regression was performed to analyze the data. Estimates were reported in adjusted odds ratios with 95% confidence intervals (CI) and a significant association was declared at p-value of less than 0.05.ResultThe overall adherence level of the community towards the recommended safety measures of COVID-19 was 44.1%. Self-efficacy (AOR = 0.23; 95% 0.14, 0.36), perceived benefits (AOR = 0.35; 95% 0.23, 0.56), perceived barriers (AOR = 3.36; 95% 2.23, 5.10), and perceived susceptibility of COVID-19 (AOR = 1.60; 95% 1.06, 2.39) were important predictors that influenced the adherence of the community to COVID-19 preventive behaviors.ConclusionsIn this study, the overall adherence level of the community towards the recommended safety measures of COVID-19 was relatively low. It is vital to consider the communities’ self-efficacy, perceived benefits, perceived barriers and perceived susceptibility of COVID-19 in order to improve the adherence of the community towards the recommended safety measures of COVID-19.
Natalia Álvarez Méndez y Ana Abello Verano (eds.). Realidades fracturadas. Estéticas de lo insólito en la narrativa en lengua española (1980-2018). Madrid: Visor Libros, 2019.
Authors: Ruiz Pérez Nieves 
Published: January 2021

Reseña de Nieves Ruiz Pérez (Universidad de Granada): Natalia Álvarez Méndez y Ana Abello Verano (eds.). Realidades fracturadas. Estéticas de lo insólito en la narrativa en lengua española (1980-2018). Madrid: Visor Libros, 2019. ISBN: 9788498952131
Cover crops, lime and gypsum influence on soil physical attributes
Authors: Oliveira Marcela Pacola , Roque Cassiano Garcia , Piati Gabriel Luis , Alvarez Rita de Cassia Felix , Carvalho Marco Antonio Camilo de , Campos Cid Naudi  Silva , Teodoro Paulo Eduardo 
Published: January 2021

Cover crops promote nutrient cycling, and lime and gypsum can alter the soil physical attributes. This study aimed to evaluate the effect of lime and gypsum rates applied to a no-tillage system with addition of residues of three cover crops on the soil physical attributes. This experiment was carried out in chapadão do sul-ms. The treatments were comprised of three cover crops (Urochloa ruziziensis, fallow, and Pennisetum glaucum), with gypsum (0, 2.3 and 4.6 Mg ha-1) and lime applied at a dose of 0, 2, 4, 6 Mg ha-1).The attributes evaluated were: soil density, macroporosity, microporosity, total porosity and penetration resistance. The soil of the experiment was classified an Oxisol. Cover crops and lime and gypsum improved macroporosity, microporosity and total porosity at all depths, 0-0.2 m. Millet presented lower values for penetration resistance with the lime application and without gypsum application. No residual effect on soil density was detected for lime and gypsum application or cover crops in the 0.1-0.2 m layer. Brazilian Cerrado producers will have a well-defined management system to follow aiming at improving the soil physical attributes.
Characterization and plasticity of wharton's jelly mesenchymal stem cells of goat
Authors: Neves Gustavo Cardoso da Silva , Argôlo Neto Napoleão Martins , Ferraz Maíra Soares , Da Costa Clautina Ribeiro de Moraes , Da Rocha Andressa Rêgo , Rodrigues Huanna Waleska Soares , Nunes Felipe de Carvalho , De Carvalho Camila Ernanda Sousa , Cavalcante Filho Miguel Ferreira , De Menezes Danilo José Ayres , De Carvalho Maria Acelina Martins 
Published: January 2021

Mesenchymal stem cells (MSCs), obtained from several anatomical sites, have already been described, characterized and used in therapeutic models for tissue repair. The umbilical cord mesenchymal stem cells, represented by cells from arteries and veins walls, as well as Wharton's jelly are easy to be obtained, highly available, require no invasive procedure, do not present risk to donors and do not present ethical limitation. The aim of this research was to analyze the plasticity of Wharton's jelly mesenchymal stem cells (WJ-MSCs) of goat, evaluating their behavior in vitro and characterizing them immunophenotypically. Thus, tests were performed on colony forming units, viability and cell growth curve, flow cytometry analysis and plasticity potential. Goat umbilical cord matrix cells exhibited fibroblastoid morphology with colony formation and self-renewal ability, always maintaining their undifferentiated state up to the eighth passage (P8). The growth curve kinetics exhibited the LAG, LOG, and DECAY phases, without displaying a PLATEAU phase. The plasticity assay demonstrated positive differentiation for osteogenic, adipogenic and chondrogenic lines, characterized by the synthesis of intracytoplasmic granules or extracellular matrix with the presence of calcium, lipids and proteoglycans. Flow cytometry demonstrated the expression of CD90 and CD105; absence of CD14 expression. It is concluded that the cell population isolated from the Wharton's jelly of goat constitutes a representative sample of mesenchymal stem cells, with great possibilities in the field of regenerative and reproductive medicine.
Exports and the economic performance of large state-owned enterprises in Poland: evidence from firm-level data
Authors: Szarzec Katarzyna , Nowara Wanda , Olejnik Iwona 
Published: January 2021

The aim of this paper is to investigate the relation between exports and economic performance, and the extent of state ownership in the largest non-financial enterprises in Poland in 2011–2015. We address the following research questions: (i) What is the share of export companies in the group of the largest non-financial enterprises in Poland in terms of ownership structure (stateowned and privately-owned companies) and sectors? (ii) Are there differences in the economic performance of exporting companies compared to their non-exporting counterparts? Among the largest exporters, state-owned companies and companies from the manufacturing and mining sectors still dominate. Exporting state-owned enterprises have higher productivity than non-exporters, which could be caused by their dominant position on the domestic oligopolistic market. Exporting private-owned companies performed better in the case of ROA and ROE than exporting SOEs. This could be explained by the fact that private companies have a higher efficiency of property management and are expected to pay dividends by their shareholders.
Some properties of the Hermite polynomials
Authors: Qi Feng , Guo Bai-Ni 
Published: January 2021

Abstract
In this paper, by the Faà di Bruno formula and properties of Bell polynomials of the second kind, the authors reconsider the generating functions of Hermite polynomials and their squares, find an explicit formula for higher-order derivatives of the generating function of Hermite polynomials, and derive explicit formulas and recurrence relations for Hermite polynomials and their squares.
In defense of decentralized research data management
Authors: Hanke Michael , Pestilli Franco , Wagner Adina S. , Markiewicz Christopher J. , Poline Jean-Baptiste , Halchenko Yaroslav O. 
Published: January 2021

Abstract
Decentralized research data management (dRDM) systems handle digital research objects across participating nodes without critically relying on central services. We present four perspectives in defense of dRDM, illustrating that, in contrast to centralized or federated research data management solutions, a dRDM system based on heterogeneous but interoperable components can offer a sustainable, resilient, inclusive, and adaptive infrastructure for scientific stakeholders: An individual scientist or laboratory, a research institute, a domain data archive or cloud computing platform, and a collaborative multisite consortium. All perspectives share the use of a common, self-contained, portable data structure as an abstraction from current technology and service choices. In conjunction, the four perspectives review how varying requirements of independent scientific stakeholders can be addressed by a scalable, uniform dRDM solution and present a working system as an exemplary implementation.