bluuebunny/crossref_metadata_2025_split huggingface dataset:
The metronome marks for Beethoven’s Ninth Symphony in context
Authors: Noorduin Marten 
Published: February 2021

Abstract
In recent years, Beethoven’s metronome marks for his Ninth Symphony have experienced a renewed relevance, with several ensembles incorporating the indicated speeds in their performances. Nevertheless, previous research has shown that some of the marks have been incorrectly transmitted, and there is the suspicion that further mistakes are still undiscovered. Focusing particularly on the second and fourth movements, this article discusses the historical sources and scholarly contexts for these markings, within a historical framework that draws on Beethoven’s general tempo principles, as well as observations from contemporaries. The article suggests that the trio of the second movement has three speeds that can be justified historically, although the most popular option, minim = 160, arguably has the least supporting evidence. The discussion also draws attention to another metronome mark for the final section of the symphony that has been often overlooked. Finally, it argues that one of the most often cited examples of an erroneously transmitted metronome mark, the dotted minim = 96 for the Schreckensfanfare found in the later sources, is consistent with Beethoven’s wider practice, and should provide an incentive for performers to experiment with historically informed tempi in this familiar repertory.
Bicarbonate uptake rates and diversity of RuBisCO genes in saline lake sediments
Authors: Wang Beichen , Huang Jianrong , Yang Jian , Jiang Hongchen , Xiao Haiyi , Han Jibin , Zhang Xiying 
Published: February 2021

ABSTRACTThere is limited knowledge of microbial carbon fixation rate, and carbon-fixing microbial abundance and diversity in saline lakes. In this study, the inorganic carbon uptake rates and carbon-fixing microbial populations were investigated in the surface sediments of lakes with a full range of salinity from freshwater to salt saturation. The results showed that in the studied lakes light-dependent bicarbonate uptake contributed substantially (&gt;70%) to total bicarbonate uptake, while the contribution of dark bicarbonate uptake (1.35–25.17%) cannot be ignored. The light-dependent bicarbonate uptake rates were significantly correlated with pH and turbidity, while dark bicarbonate uptake rates were significantly influenced by dissolved inorganic carbon, pH, temperature and salinity. Carbon-fixing microbial populations using the Calvin-Benson-Bassham pathway were widespread in the studied lakes, and they were dominated by the cbbL and cbbM gene types affiliated with Cyanobacteria and Proteobacteria, respectively. The cbbL and cbbM gene abundance and population structures were significantly affected by different environmental variables, with the cbbL and cbbM genes being negatively correlated with salinity and organic carbon concentration, respectively. In summary, this study improves our knowledge of the abundance, diversity and function of carbon-fixing microbial populations in the lakes with a full range of salinity.
Characterization of carotenoids and genes encoding their biosynthetic pathways inAzospirillum brasilense
Authors: Mishra Shivangi , Singh Chanotiya Chandan , Shanker Karuna , Kumar Tripathi Anil 
Published: February 2021

AbstractAzospirillum brasilense is a non-photosynthetic member of the family Rhodospirillaceae. Some strains of this bacterium are reported to produce bacterioruberin type of carotenoids, which are generally produced by halophilic or psychrophilic bacteria. Since no other member of Rhodospirillaceae produces bacterioruberin type of carotenoids, we investigated the presence of genes involved in bacterioruberin and spirilloxanthin biosynthetic pathways in A. brasilense Cd. Although genes encoding the spirilloxanthin pathway were absent, homologs of several genes (crtC and crtF) involved in the biosynthesis of bacterioruberins were present in the genome of A. brasilense Cd. However, the homolog of CruF responsible for the final step in bacterioruberin biosynthesis could not be found. We also characterized the carotenoids of A. brasilense Cd using thin-layer chromatography, high-performance liquid chromatography, absorption spectra and high-resolution mass spectrometry (HRMS). Resolution of the methanol extract of carotenoids in ultra-performance liquid chromatography showed nine peaks, out of which six peaks showed absorption spectra characteristic of carotenoids. HRMS of each peak produced 1–14 fragments with different m/z values. Two of these fragments were identified as 19′-hydroxyfucoxanthinol and 8′-apoalloxanthinal, which are the carotenoids found in aquatic microalgae.
Relationship Between Geographical Indications and Trade Marks under Turkish Law
Authors: Tekin Ufuk 
Published: February 2021

Abstract
While geographical indications show geographical origin, trade marks show commercial origin. Therefore, it is possible to say that both geographical indications and trade marks have distinctive character. Indeed, when an application is filed to register a geographical indication as a trade mark, an important question is whether the sign is distinctive enough. In such cases, the distinctive character of these commercial and geographical ‘signs’ can overlap and intersect with each other. In this article, the intersection and relationship between geographical indications and trade marks will be evaluated by considering two different scenarios. In the first one, the trade mark application precedes the registration of the geographical indication, while in the second the application for the geographical indication is filed before the conflicting trade mark. The analysis is carried out by taking into account various provisions of the Turkish Industrial Property Code (IPC), the judicial practice of the Turkish Court of Cassation and international regulations. In this context, the relationship between several absolute grounds for refusal in such a situation and which of these provisions is the most applicable will be examined. In particular, an attempt will be made to explain the role of the absolute ground for refusal regulated in the new Turkish Industrial Property Code for the first time, namely that signs containing or consisting of a geographical indication cannot be registered as a trade mark (Art. 5.1(i)).
Investigating the effects of environmental patents and climate change mitigation technologies on sustainable economic growth in the Middle East
Authors: Abedi Sadegh , Moeenian Mehrnaz 
Published: February 2021

Abstract
Sustainable economic growth and identifying factors affecting it are among the important issues which have always received attention from researchers of different countries. Accordingly, one of the factors affecting economic growth, which has received attention from researchers in the developed countries over recent years, is the issue of environmental technologies that enter the economic cycle of other countries after being patented through technology transfer. The current research investigated the role of the environment-related patents and the effects of the patented technological innovations compatible with climate change mitigation on the economic growth and development in the Middle East countries within a specific time period. The required data were gathered from the valid global databases, including Organization for Economic Co-operation and Development and World Bank and have been analyzed using multi-linear regression methods and econometric models with Eviews 10 software. The obtained results with 95% confidence level show that the environmental patents (β = 0.02) and environment management (β = 0.04) and technologies related to the climate change mitigation (β = 0.02) have a significant positive impact on the sustainable economic development and growth rate in the studied countries. Such a study helps innovators and policymakers in policy decisions related to sustainable development programs from the perspective of environmentally friendly technologies by demonstrating the role of patents in three important environmental areas, namely environmental management, water-related adaptation and climate change mitigation, as one of the factors influencing sustainable economic growth.
An HDG method for the Steklov eigenvalue problem
Authors: Monk Peter , Zhang Yangwen 
Published: February 2021

Abstract
We propose a hybridizable discontinuous Galerkin (HDG) method for approximating the Steklov eigenvalue problem. We prove optimal convergence rates for the eigenvalues and the eigenfunctions, and under some regularity assumptions we obtain a superconvergent rate for the eigenvalues. Moreover, after we eliminate the flux variable and the scalar variable, the reduced eigenvalue problem is linear and our result holds on any sufficiently regular mesh made of general polyhedral elements. Finally, we present numerical experiments to confirm our theoretical results.
The Effects of “Dry Swab” Incubation on SARS-CoV-2 Molecular Testing
Authors: Parikh Bijal A , Wallace Meghan A , McCune Broc T , Burnham Carey-Ann D , Anderson Neil W 
Published: February 2021

Abstract

Background
Widespread testing of SARS-CoV-2 has resulted in shortages of collection devices and transport media. We evaluated the stability of flocked swabs inoculated with SARS-CoV-2-containing specimen incubated dry (i.e., without transport medium) at room temperature.

Methods
A pool of SARS-CoV-2 positive specimen was used to inoculate flocked swabs. Five swabs were placed immediately into universal transport media (UTM) following inoculation, and tested immediately (day 0). Fifteen of the swabs were placed into sterile 15-mL conical tubes and incubated at room temperature for 1, 2, or 7 days. Following incubation, swabs were hydrated in separate vials of UTM and tested. This protocol was repeated for viral transport media (VTM) and saline. As a comparison, a series of swabs was prepared and tested in parallel, but stored in the corresponding liquid transport media (UTM, VTM, or saline) and incubated at room temperature. Testing was performed at 1, 2, and 7 days postinoculation in duplicate. All molecular testing was performed using the Roche cobas SARS-CoV-2 assay.

Results
All dry swabs tested on days 1, 2, and 7 provided results that were within 2 cycle thresholds (CTs) of the average CT values for swabs hydrated in the same media and tested on day 0. There was no statistical difference in CT values between swabs incubated in liquid media versus dry swabs incubated at room temperature prior to hydration in liquid media.

Conclusions
The utilization of “dry swabs” may simplify specimen collection, negate the need for liquid transport media, and mitigate safety risks while preserving the accuracy of testing.
Diagnosis of a chronic spinal cord injury via televisit in a patient from an underserved community
Authors: Breton Jeffrey M , George Keith M , Riesenburger Ron I 
Published: February 2021

Abstract
A 42-year-old woman from a medically underserved community in rural New England was referred by her primary care provider (PCP) for televisit during the coronavirus disease 2019 (COVID-19) pandemic following 2 years of chronic neck pain and numbness in her left hand that was initially concerning for demyelinating disease. Upon further evaluation, it was revealed that she had experienced a traumatic fall with a concussion and symptoms consistent with central cord syndrome but had refused magnetic resonance imaging (MRI) at her initial medical evaluation. On MRI conducted 1 month prior to neurosurgical evaluation she was found to have a disc bulge and 4-mm T2-hyperintense lesion at the C4–C5 level that was consistent with a chronic spinal cord injury secondary to spinal trauma with associated vertebrogenic injury. This televisit confirmed the diagnosis of chronic spinal cord injury for this patient and allowed for discussion of future interventions, avoided further unnecessary referrals, and increased access to care.
A comparative study of the strength of flickering in cataclysmic variables
Authors: Bruch Albert 
Published: February 2021

ABSTRACT
Flickering is a universal phenomenon in accreting astronomical systems that still defies detailed physical understanding. It is particularly evident in cataclysmic variables (CVs). Attempting to define boundary conditions for models, the strength of the flickering is measured in several thousand light curves of more than 100 CVs. The flickering amplitude is parametrized by the full width at half-maximum of a Gaussian fit to the magnitude distribution of data points in a light curve. This quantity requires several corrections before a comparison between different sources can be made. While no correlations of the flickering strength with simple parameters such as component masses, orbital inclination, or period were detected, a dependence on the absolute magnitude of the primary component and on the CV subtype is found. In particular, flickering in VY Scl type novalike variables is systematically stronger than in UX UMa type novalikes. The broad-band spectrum of the flickering light source can be fit by simple models but shows excess in the U band. When the data permitted to investigate the flickering strength as a function of orbital phase in eclipsing CVs, such a dependence was found, but it is different for different systems. Surprisingly, there are also indications for variations of the flickering strength with the superhump phase in novalike variables with permanent superhumps. In dwarf novae, the flickering amplitude is high during quiescence, drops quickly at an intermediate magnitude when the system enters into (or returns from) an outburst and, on average, remains constant above a given brightness threshold.
Height in adolescence as a risk factor for glioma subtypes: a nationwide retrospective cohort study of 2.2 million subjects
Authors: Tschernichovsky Roi , Katz Lior H , Derazne Estela , Berliner Matan Ben-Zion , Simchoni Maya , Levine Hagai , Keinan-Boker Lital , Benouaich-Amiel Alexandra , Kanner Andrew A , Laviv Yosef , Honig Asaf , Dudnik Elizabeth , Siegal Tali , Mandel Jacob , Twig Gilad , Yust-Katz Shlomit 
Published: February 2021

Abstract

Background
Gliomas manifest in a variety of histological phenotypes with varying aggressiveness. The etiology of glioma remains largely unknown. Taller stature in adulthood has been linked with glioma risk. The aim of this study was to discern whether this association can be detected in adolescence.

Methods
The cohort included 2 223 168 adolescents between the ages of 16 and 19 years. Anthropometric measurements were collected at baseline. Incident cases of glioma were extracted from the Israel National Cancer Registry over a follow-up period spanning 47 635 745 person-years. Cox proportional hazard models were used to estimate the hazard ratio (HR) for glioma and glioma subtypes according to height, body mass index (BMI), and sex.

Results
A total of 1195 patients were diagnosed with glioma during the study period. Mean (SD) age at diagnosis was 38.1 (11.7) years. Taller adolescent height (per 10-cm increase) was positively associated with the risk for glioma of any type (HR: 1.15; P = .002). The association was retained in subgroup analyses for low-grade glioma (HR: 1.17; P = .031), high-grade glioma (HR: 1.15; P = .025), oligodendroglioma (HR: 1.31; P = .015), astrocytoma (HR: 1.12; P = .049), and a category of presumed IDH-mutated glioma (HR: 1.17; P = .013). There was a trend toward a positive association between height and glioblastoma, however this had borderline statistical significance (HR: 1.15; P = .07). After stratification of the cohort by sex, height remained a risk factor for men but not for women.

Conclusions
The previously established association between taller stature in adulthood and glioma risk can be traced back to adolescence. The magnitude of association differs by glioma subtype.
Mary Midgley
Authors: McKinnell Liz 
Published: February 2021

Mary Beatrice Midgley (née Scrutton; b. 13 September 1919–d. 10 October 2018) wrote twenty philosophical books that use an engaging style and surprisingly domestic metaphors to convey profound thought about a diverse range of topics, including human nature, animals, environmentalism, ethics, science, gender, and the practice of philosophy itself. Her first book was the influential Beast and Man, published in 1978, and her last was What Is Philosophy For?, a defense of the need for philosophical thinking, published just before her death at the age of ninety-nine. Midgley has recently garnered more philosophical attention and is now widely recognized as an original and incisive voice in philosophy. The daughter of a pacifist curate, Midgley was born in Dulwich, London, before moving to Cambridge, Greenford, and Kingston. A nature-loving child, with passions for drama and poetry, she was educated at Downe House School near Newbury, before reading Classics and Greats at Somerville College, Oxford, between 1938 and 1942. Here she met her fellow members of the wartime Quartet of women philosophers (see the separate Oxford Bibliographies in Philosophy articles on “G. E. M. Anscombe,” “Philippa Foot,” and “Iris Murdoch”). The four became great friends and influenced each other throughout their working lives. Their connections include a frustration with the narrowness of the systematic philosophy that was in vogue during their formative years, and the revival of virtue in moral philosophy. Unlike her contemporaries, Midgley published little work until her fifties, after she had raised children and left academic philosophy. As Midgley said, “I wrote no books until I was a good 50, and I’m jolly glad because I didn’t know what I thought before then.” For this reason, Midgley’s writing is striking in its consistency. Articles of this kind often chart changes of mind and theoretical revisions. While Midgley’s thought undoubtedly developed and expanded, there are no early or late periods, marked by stark differences of view. One of Midgley’s criticisms of her predecessors concerned their neglect of the history of ideas. Midgley holds that to understand a philosophical system, we must understand the context in which it arose. Philosophy and culture are interconnected: the great thinkers of any era are influenced by their historical circumstances, and the patterns of thought within a culture are, whether we realize it or not, profoundly philosophical. Philosophy, she argues, is indispensable, because it allows us to make sense of our current predicaments and—where necessary—make changes to our patterns of thought.
Isaac Newton
Authors: Snobelen Stephen D. 
Published: February 2021

Isaac Newton (b. 1642–d. 1727) played a pivotal role in the early modern Scientific Revolution through his contributions in three fields: mathematics, optics, and physics. Additionally, Newton contributed to the scientific method, designed and built the first working reflecting telescope, engaged in extensive correspondence with other natural philosophers, and served as president of the Royal Society of London for more than a quarter century. His accomplishments also include his leadership at the Royal Mint in London (first as warden in 1696 and then as master from 1699 until his death). He was knighted by Queen Anne in 1705. Newton’s life can be divided into three phases according to geographical region. From 1642 to 1661 he lived in Lincolnshire, where he was born (Woolsthorpe) and attended grammar school (the King’s School, Grantham). He came to Trinity College in 1661 to begin his undergraduate training and became Lucasian Professor of Mathematics in 1669. In 1696, he moved to London to take his position at the Mint. He was given a state funeral and buried at Westminster Abbey. Newton’s development of calculus introduced a potent mathematical tool with a wide range of applications (Gottfried Leibniz independently shared this innovation); his prism experiments showed that sunlight is heterogenous; his three laws of motion continue to serve physics and engineering; and his inverse-square law of universal gravitation helped make planetary science and the Space Age possible. Newton’s status as a polymath is underscored by his practice of alchemy (chymistry), and his forays into chronology and his study of doctrine, prophecy, and church history. The steadily increasing collection of transcribed manuscripts produced by the Newton Project has given scholars unprecedented access to his thought and has made research into the interrelations between his intellectual endeavors possible. In addition to being important to science and scientists, Newton is studied by historians, historians of science, philosophers, philosophers of science, theologians, sociologists, and literary scholars. This article on Newton and Newtonianism reflects this range of study and brings together classic studies along with cutting-edge research. Note: articles alluded to in summaries of collections of papers are mostly not repeated elsewhere under the specific subject headings.
Wilhelm Wundt
Authors: Araujo Saulo de Freitas 
Published: February 2021

Wilhelm Maximilian Wundt (b. 1832―d. 1920) was a central figure in German culture between the second half of the 19th century and the first two decades of the 20th century. Coming from a medical and neurophysiological background with a PhD in medicine, Wundt shifted his interest toward psychological and philosophical questions, becoming full professor of philosophy: first, at the University of Zurich in 1874; then, at the University of Leipzig in 1875. In the early 21st century, he is known worldwide as one of the founders of scientific psychology. In Leipzig, he founded in 1879 the Psychological Laboratory, which later became the first psychological institute in the world. Moreover, he founded the first journal for experimental psychology, which he called Philosophische Studien (Philosophical Studies), later Psychologische Studien (Psychological Studies). In so doing, he created the first international training center for psychologists, attracting to Leipzig students from all over the world. Wundt had a significant impact upon the development of scientific psychology in many countries, not least in the United States, where his former students founded psychological laboratories inspired by the Leipzig model. Apart from his contributions to psychology, Wundt also developed a philosophical system that is crucial to understanding his psychological program and methodology, but which has not received due attention among psychologists. Wundt’s writings have been published in different, mostly enlarged editions throughout his career. The great majority of these volumes have not yet been translated into English, and the same holds true for much of the relevant research literature.