bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efecto de la alimentación natural con organismos del meiobentos marino y biofloc sobre los parámetros de producción en el cultivo de camarón Penaeus vannamei
Authors: Ibarra-Mayorga Teresa Eulalia , Jijón-Vergara Ariana Solange , Proaño-Morales Jonathan Josue , Cobeña-Veliz Víctor Alfonso 
Published: December 2021

Con el crecimiento demográfico, el consumo de camarón aumenta exponencialmente, por lo cual es imprescindible la búsqueda de nuevas tecnologías que disminuyan costos y optimicen la producción. Los sistemas biofloc compuestos por bacterias, algas, protozoos y metazoos han sido considerados una alternativa eficiente como suplemento alimentario en el cultivo de camarón. Además, el suministro de meiofauna en los cultivos tiene efectos positivos en el crecimiento del camarón debido a su alto contenido proteico y de ácidos grasos poliinsaturados. Se evaluó el efecto de la alimentación natural con organismos del meiobentos marino y biofloc sobre los paramentos de producción en el cultivo de Penaeus vannamei. El ensayo se realizó en temporada de verano y se analizaron parámetros de calidad del agua e indicadores productivos. La densidad inicial de cultivo fue 40 postlarvas por 0,18 m2. Se utilizó un diseño experimental completamente aleatorizado conformado por cuatro tratamientos con tres réplicas. En el tratamiento 1 (B), se utilizó la tecnología convencional para cultivo de camarón, con alimento balanceado y agua de mar. En el tratamiento 2 (S) se colocó una capa de cinco centímetros de sustrato arenoso fino y alimento balanceado. En el tratamiento 3 (S-Bf) se añadió sustrato, biofloc y alimento balanceado. En el tratamiento 4 (B-Bf) se aplicó biofloc y alimento balanceado. Los valores de temperatura, pH, salinidad, oxígeno disuelto, sólidos suspendidos, nitrito, nitrato y amoniaco se mantuvieron dentro de los parámetros óptimos para la especie. El tratamiento que tuvo el mayor peso final fue S-Bf (1,17 g) y el tratamiento que reportó menor peso fue el B con 0,76 g. Los resultados sugieren que la combinación de los flóculos bacterianos del biofloc más los micro invertebrados meiobentónicos pueden constituir una estrategia para mejorar la productividad del cultivo y mantener los parámetros ambientales en intervalos óptimos.
Development of motor abilities in girls with scoliosis of 1-2 degrees by means of recreational aerobics and therapeutic physical culture
Authors: Podlubnaya A.A. , Balashova V.F. 
Published: December 2021

In the specialized literature, you can find data from a number of authors indicating that children with scoliosis have a lag in the level of physical development and physical fitness. The article presents the results of a study indicating the positive effect of recreational aerobics and therapeutic physical culture on the development of motor abilities in primary school-age girls with 1-2-degree scoliosis.
Key words: health, posture, scoliosis, aerobics, therapeutic physical education, development.
The effectiveness of the use of sensory-motor correction in children with autism spectrum disorders in the process of adaptive physical education
Authors: Safronova A.A. , Akhtimirova E.A. 
Published: December 2021

The study involved 10 children aged 8 to 12 years with a diagnosis of autism spectrum disorder (ASD). Combinations of physical exercises were used, for the main muscle groups, and effects on the tactile, proprioceptive and vestibular sensory systems. The exercises are performed using the shells of the sensory-dynamic hall, which includes a number of various suspended modular elements. The data obtained showed the effectiveness of using sensory-motor correction to improve motor functions, normalize motor and vestibular sensitivity, form muscle feeling and differentiate muscle efforts, form and correct visual-motor coordination and attention.
Key words: autism spectrum disorders, sensory integration, sensory-motor correction, sensory-dynamic hall.
Adaptive chemoreceptor plasticity and reactivity of the cardio-respiratory system in athletes under hypoxic loads
Authors: Balioz N.V. , Krivoshshekov S.G. 
Published: December 2021

An exploration of 110 healthy men (not involved in sports and athletes) with the use of hypoxic loads was carried out. It is established that the specifics of the regulation of gas exchange depend on the nature of training loads (aerobic or mixed), which are manifested in the parameters of chemoreflector reactivity, the pattern of external respiration, gas exchange and activity of the autonomic nervous system under hypoxic load. As sports qualifications grow, the mechanisms of intersystem integration of the functions of the cardio-respiratory system are improved, which is manifested in an increase in cardiorespiratory coherence.
Key words: athletes, hypoxia, cardiorespiratory system, gas exchange of the body, chemoreceptor reactivity.
Peculiarities of immunophysiological shifts in adaptation to climatic and geographical conditions of mountains
Authors: Tyumonbaeva N.B. , Kazybekova A.A. , Mamytova N.J. , Myrzakulova A.J. 
Published: December 2021

The functioning of the immune system of people exposed to prolonged exposure to natural factors has been monitored and the main immunity indicators have been studied in practically healthy population of different mountain heights in Chui and Naryn regions. Indicators of specific immunity in the residents of the zone of compensated discomfort is reduced compared with the standards of the zone of relative comfort and refers to the mixed type with suppression of cellular and humoral immunity, apparently, this is associated with the climatic and geographical and environmental characteristics of the region.
Key words: adaptation, immune system, T- lymphocytes, B- lymphocytes, immunoglobulins, circulating immune complexes, mountainous conditions.
On the Possibilities of Using the Body Mass Index Index to Reveal Trends in Changing the Health Status of Student Youth
Authors: Shvechikhina Yu.V. , Ishchenko K.S. , Kavelenova L.M. 
Published: December 2021

The article is devoted to the study of body mass index (BMI) indicators of biology students at Samara University in 20008-2020. For girls, against the background of fluctuations over the years, from 2015-2016 to 2020. there is a consistent decrease in the proportion of people with underweight, an increase in the proportion of people with normal weight. For young men, changes in the BMI structure are of a more pronounced oscillatory character. The negative features of the 2019 and 2020 contingent are the emergence of overweight and obese people.
Key words: students, physical health, body weight, Samara region, body mass index.
Synthesis of chelated compounds of amino acids with metals
Authors: Yamskikh A.A. , Ivanova L.A. 
Published: December 2021

The article describes the reactions of glycine synthesis with alkaline, alkaline-earth and divalent 3-d metals, which were carried out during the experiment. Hydroxides or sulfates of lithium, magnesium, calcium, manganese, iron, copper, zinc, cobalt and sodium were used as reagents for the synthesis. The physicochemical properties of the obtained compounds were studied.
Keywords: chelates, glycinates of alkaline and alkaline earth metals, glycinates of divalent 3-d metals.
Drinking water contaminants as risk factors for the health of the Ulyanovsk region population
Authors: Ermolaeva S.V. 
Published: December 2021

The main goal of health risk analysis is to obtain and generalize information about the possible influence of environmental factors on human health. As a result of hydrochemical analysis of drinking water supply sources in the Ulyanovsk region, a list of main contaminants has been established. It includes ammonium, iron, copper, phosphates, sulfates, chlorides, nitrates, zinc, manganese and chromium. Among them three pollutants - iron, manganese and sulfates – had surpassed maximum permissible concentration. The concentration of iron at the level of threshold chronic effects was found in drinking water of Baryshsky (0.13), Melekessky (0.16), Sengileevsky (0.13) districts. Severe chronic effects can be caused by the concentration of iron and manganese in the drinking water of the Staromainsky (0.4 and 0.3) and Cherdaklinsky (0.9 and 0.27) districts. Assessment of health risks led us to the conclusion that drinking water can serve as an additional risk factor and provoke disease development.
Key words: risk factors, morbidity, maximum permissible concentration, pollutants, relative conditional risk, average daily dose.
Analisa Penggunaan CDI Racing Programmable Pada Mesin Sepeda Motor Jupiter Z 110 CC
Authors: Nazar Nazaruddin , Weriono  
Published: December 2021

CDI racing programmble merupakan komponen yang banyak di jumpai di pasaran otomotif. Penggantian CDI racing programmmble bertujuan untuk meningkatkan performa kinerja mesin. Penelitian Analisa penggunaan CDI racing programmble dilakukan pada mesin sepeda motor Jupiter Z 110 cc. Pengujian dilakukan pada empat kondisi yaitu CDI Standar, CDI racing programmable maping 20, CDI racing programmable maping 25, CDI racing programmable maping 30. Parameter yang dicari adalah torsi, daya dan konsumsi bahan bakar.Variasi putaran pada putaran mesin 3000, 4000, 5000, 6000, 7000, rpm.
Perbandingan torsi tertinggi di dapat pada variasi CDI racing programmable maping 30 yaitu9,26 N.m pada putaran mesin 3349 rpm dan daya paling besar juga dihasilkan oleh CDI racing programmable maping 30 yaitu 7,9 HP pada putaran mesin 7624 rpm dikarenakan penggunaan CDI racing programmble menghasilkan pengapian yang lebih besar dari standarnya. Sehingga proses pembakaran akan menjadi lebih cepat di ruang bakar. Konsumsi bahan bakar paling rendah didapat pada penggunaan CDI racing programmable maping 30 yaitu 08,25 kg/Hp. Penggunaan CDI racingprogrammble mempengaruhi konsumsi bahan bakar karena pengapian yang dihasilkan lebih besar jadi pembakaran lebih cepat dan lebih sempurna di ruang bakar.
Pengaruh Latihan Skipping Terhadap Kecepatan Tendangan Sabit Peserta Ekstrakurikuler di SMP Negeri 1 Nagrak Kabupaten Sukabumi
Authors: Ferdiansyah Fian 
Published: December 2021

Tujuan dari penelitian ini adalah Untuk mengetahui pengaruh latihan skipping serta pengaruh latihan tradisional/konvensional terhadap kecepatan tendangan sabit peserta ekstrakurikuler pencak silat di SMP Negeri 1 Nagrak Kabupaten Sukabumi, maupun perbedaan pengaruh latihan skipping dengan latihan tradisional/konvensional terhadap kecepatan tendangan sabit peserta ekstrakurikuler pencak silat di SMP Negeri 1 Nagrak Kabupaten Sukabumi.
Teknik pengambilan sampel yang digunakan adalah teknik sampel jenuh dimana semua anggota populasi digunakan sebagai sampel dengan teknik pengumpulan data yang digunakan yaitu observasi langsung, dokumentasi, serta menggunakan alat untuk melakukan penelitian. Sedangkan teknik analisis data yang digunakan adalah mencari rata-rata hitung, uji normalitas menggunakan teknik Kolmogorov-Smirnov dan Shafiro-Wilk test, uji homogenitas, Uji hipotesis dilakukan dengan menggunakan one sample test t-test.semua pengujian analisis data menggunakan SPSS.
Hasil dari penelitian adalah sebagai berikut 1) Ada pengaruh antara latihan dengan media skipping terhadap kecepatan tendangan sabit pada peserta ekstrakurikuler pencak silat SMP Negeri 1 Nagrak Kabupaten Sukabumi. 2) Tidak ada pengaruh antara latihan non program terhadap kecepatan tendangan sabit pada peserta ekstrakurikuler pencak silat SMP Negeri 1 Nagrak Kabupaten Sukabumi.3) Latihan dengan media skipping lebih berpengaruh terhadap kecepatan tendangan sabit pada peserta ekstrakurikuler pencak silat SMP Negeri 1 Nagrak Kabupaten Sukabumi.
« L’oralité à bras-le-corps ». Clinique sensori-motrice des troubles alimentaires du tout-petit en psychiatrie périnatale
Authors: Rabassa Novélie , Saint Ges Lucie 
Published: December 2021

« Mon bébé ne mange pas bien » est un motif de consultation courant en pédiatrie comme en pédopsychiatrie. En psychomotricité, il nous semble alors essentiel d’observer un repas et d’évaluer les compétences sensori-motrices du bébé. Il s’agit aussi d’affiner notre compréhension des appuis et des moyens de régulation fournis par l’entourage. En effet, l’exploration de la bouche, la découverte des sensations, comme les praxies fines, sont indissociables des appuis posturaux et relationnels fournis par les proches. Dans la clinique, ce sont parfois les difficultés d’accordage qui sont au premier plan dans la dyade. Parfois, ce sont les difficultés sensori-motrices qui viennent perturber les ajustements parentaux, les conduites de la bouche et, in fine , l’organisation corporelle du bébé. Dans les deux cas, l’enjeu, en psychomotricité, est avant tout de trouver avec le parent comment il peut prendre son enfant « à bras-le-corps » afin de lui donner les appuis dont il a besoin pour aborder avec plus de plaisir les repas.
ARTICLE RETIRÉ : Psychologie et école, un couple devenu historique
Authors: Marmonier Fabien 
Published: December 2021

La psychologie s’est progressivement installée au sein du système scolaire. À travers deux aspects seront abordés les enjeux de la place occupée par la psychologie dans l’École : d’une part, l’évolution de la professionnalisation des psychologues de l’éducation nationale ; d’autre part l’entrée de la recherche en psychologie dans les programmes d’enseignement, à travers l’exemple de la théorie de l’esprit.
Newborn Eye Screening as an Application of AI
Authors: Kumm Jochen 
Published: December 2021

Artificial intelligence (AI) applications are diverse and serve varied functions in clinical practice. The most successful products today are clinical decision tools used by physicians, but autonomous AI is gaining traction. Widespread use of AI is limited in part because of concerns about bias, fault-tolerance, and specificity. Adoption of AI often depends on removing cost and complexity in clinical workflow integration, providing clear incentives for use, and providing clear demonstration of clinical outcome. Existing wide-angle photographic screening could be integrated into the clinical workflow based on prior implementations for premature babies and linked with AI interpretation with existing technology. Incidence of retinal abnormality, clinical considerations, AI performance, grading variation for AI-augmented human grading, and cost and policy aspects play a significant role. Improved outcomes for newborns and a relatively high estimated incidence of abnormality have been named as benefits to counterweigh costs in the long term.[Ophthalmic Surg Lasers Imaging Retina. 2021;52:S17–S22.]
Fatores potenciais para desenvolvimento de doença renal em adolescentes e jovens: revisão integrativa/ Potential factors for the development of kidney disease in adolescents and young people: integrative review
Authors: Brum dos Santos de Siqueira Francielle , Cammarano Ribeiro Aline , Tatsch Neves Eliane 
Published: December 2021

Objetivo: identificar evidências científicas acerca dos fatores potenciais para o desenvolvimento de doença renal crônica em adolescentes e jovens. Método: revisão integrativa, utilizando uma ficha de seleção para extração dos dados das pesquisas nas bases de dados: Literatura Latino Americana e do Caribe em Ciências da Saúde, National Library of Medicine e Web Of Science, acessada via portal Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, no período de agosto de 2021, o que incluiu 12 artigos. A análise dos resultados da revisão ocorreu a partir da síntese de cada estudo primário. Resultados: as evidências científicas apontaram, como fatores potenciais para o desenvolvimento de doença renal crônica em adolescentes e jovens, as doenças crônicas, como diabetes, hipertensão, obesidade, e os fatores de risco, como uso de analgésicos, sobrepeso, baixo peso ao nascer e prematuridade. Conclusão: concluiu-se que é necessário um acompanhamento, a partir de estratégias coletivas ou individuais de educação em saúde, desses adolescentes, jovens e suas famílias, pois as doenças crônicas e fatores de risco podem ser prevenidos ou controlados.
Perfil de pacientes que concluíram o tratamento poliquimioterápico da hanseníase: um estudo transversal
Authors: Costa Pinheiro Mônica Gisele , Albino Simpson Clélia , Parreira Mendes Felismina Rosa , Nunes de Miranda Francisco Arnoldo 
Published: December 2021

Introdução: a hanseníase é uma doença infectocontagiosa que prevalece como problema de saúde pública no Brasil. Objetivo: descrever o perfil sociodemográfico, de tratamento e clínico de pacientes que concluíram o tratamento poliquimioterápico para a hanseníase. Método: estudo transversal, desenvolvido de novembro de 2017 a fevereiro de 2018 no município de Natal. A população-alvo foi constituída por 113 indivíduos cadastrados no Sistema de Informação de Agravos de Notificação e a amostra por 90, que foram notificados para a hanseníase e concluíram o tratamento poliquimioterápico, selecionados por sorteio. Os dados foram coletados por formulário, tabulados e analisados pelo SPSS 21. Quanto ao teste de Kolmogorov-Smirnov, não se observou uma distribuição de normalidade dos achados, optando-se por trabalhar com testes não paramétricos: qui-quadrado de Pearson (ou exato de Fisher) e o teste de Mann-Whitney. Resultados: predominaram indivíduos do sexo feminino, até 59 anos, com baixa renda, baixo grau de escolaridade, tratados nos centros de referência e classificados como paucibacilares. Conclusão: as condições de vulnerabilidade associada à predominância de casos tratados nos centros de referência reforçam a necessidade de organização da atenção básica para acompanhamento dos casos de hanseníase.
Class Ib MHC–Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine
Authors: Dasgupta Suryasarathi , Maricic Igor , Tang Jay , Wandro Stephen , Weldon Kelly , Carpenter Carolina S , Eckmann Lars , Rivera-Nieves Jesus , Sandborn William , Knight Rob , Dorrestein Peter , Swafford Austin D , Kumar Vipin 
Published: December 2021

Abstract
Lymphocytes within the intestinal epithelial layer (IEL) in mammals have unique composition compared with their counterparts in the lamina propria. Little is known about the role of some of the key colonic IEL subsets, such as TCRαβ+CD8+ T cells, in inflammation. We have recently described liver-enriched innate-like TCRαβ+CD8αα regulatory T cells, partly controlled by the non-classical MHC molecule, Qa-1b, that upon adoptive transfer protect from T cell–induced colitis. In this study, we found that TCRαβ+CD8αα T cells are reduced among the colonic IEL during inflammation, and that their activation with an agonistic peptide leads to significant Qa-1b–dependent protection in an acute model of colitis. Cellular expression of Qa-1b during inflammation and corresponding dependency in peptide-mediated protection suggest that Batf3-dependent CD103+CD11b− type 1 conventional dendritic cells control the protective function of TCRαβ+CD8αα T cells in the colonic epithelium. In the colitis model, expression of the potential barrier-protective gene, Muc2, is enhanced upon administration of a Qa-1b agonistic peptide. Notably, in steady state, the mucin metabolizing Akkermansia muciniphila was found in significantly lower abundance amid a dramatic change in overall microbiome and metabolome, increased IL-6 in explant culture, and enhanced sensitivity to dextran sulfate sodium in Qa-1b deficiency. Finally, in patients with inflammatory bowel disease, we found upregulation of HLA-E, a Qa-1b analog with inflammation and biologic non-response, in silico, suggesting the importance of this regulatory mechanism across species.
Enhanced Calcium Signal Induces NK Cell Degranulation but Inhibits Its Cytotoxic Activity
Authors: Li Yang , Yu Minghang , Yin Jie , Yan Han , Wang Xi 
Published: December 2021

Abstract
Although the mechanism of NK cell activation is still unclear, the strict calcium dependence remains the hallmark for lytic granule secretion. A plethora of studies claiming that impaired Ca2+ signaling leads to severely defective cytotoxic granule exocytosis accompanied by weak target cell lysis has been published. However, there has been little discussion about the effect of induced calcium signal on NK cell cytotoxicity. In our study, we observed that small-molecule inhibitor UNC1999, which suppresses global H3K27 trimethylation (H3K27me3) of human NK cells, induced a PKD2-dependent calcium signal. Enhanced calcium entry led to unbalanced vesicle release, which resulted into fewer target cells acquiring lytic granules and subsequently being killed. Further analyses revealed that the ability of conjugate formation, lytic synapse formation, and granule polarization were normal in NK cells treated with UNC1999. Cumulatively, these data indicated that induced calcium signal exclusively enhances unbalanced degranulation that further inhibits their cytotoxic activity in human NK cells.
Effect of Peptide Dose on Radiation Dosimetry for Peptide Receptor Radionuclide Therapy with 177Lu-DOTATOC
Authors: Prasad Vikas , Prasad Sonal , Lehnert Wencke , Brenner Winfried , Kai Huang , Bronzel Marcus , Kluge Andreas 
Published: December 2021

Background:
Optimal peptide concentration in treatment with 177Lu-DOTATOC/DOTATATE is a matter of debate. Most of the studies with peptide receptor radionuclide therapy mention peptide dose ranging between 100 and 250 μg. The aim of this is to identify possible differences in radiation-absorbed doses (D/Gy) to tumor and kidney as a function of the peptide mass dose in order to identify the most suitable peptide dose for treatment. The therapeutic index (Dtumor/Dkidneys) was assessed as a key parameter for the treatment response.

Materials and Methods:
Five patients with metastasized Grade 1 to Grade 2 neuroendocrine tumor were analyzed in this study. Patients (n = 4) received two cycles of treatment with intravenously injected 177Lu-DOTATOC containing peptide mass doses of 200 μg and 90 μg, alternatively; one patient was treated with 90 μg peptide mass in both the therapy cycles. Whole-body (head to mid-thigh) three-dimensional single-photon emission computerized tomography (3D SPECT)/CT images were acquired at 1, 4, 24, 48, and 72 h following the injection of 177Lu-DOTATOC. Attenuation correction for 3D SPECT images was performed using CT data acquired and fused with the SPECT data (SPECT/CT).

Results:
Overall, 28 target lesions (liver n = 17, lung n = 4, lymph nodes n = 1, and bone n = 2) were analyzed after 1st and 2nd therapy cycles. Tumor normalized absorbed doses varied by a factor of 74 between 0.35 and 26 mGy/MBq. Averaged over all patients, a higher normalized mean tumor dose (10.51 mGy/MBq) was achieved for a peptide dose of 200 μg compared to 90 μg (4.58 mGy/MBq). Kidneys doses varied by a factor of up to 4 between patients (0.25–1.0 mGy/MBq) (independent of dose cycle and peptide dose) and by a factor of up to 2 between dose cycles. The mean kidney dose was 13.7% higher for the 90 μg peptide dose compared to 200 μg. Given the higher tumor dose, the mean therapeutic index of a 200 μg mass dose was considerably higher (16.95), compared to a 90 μg mass dose (9.63). This coincided with the observation, that lesion volume reduction was more pronounced after an initial treatment with a 200 μg mass dose. Biologically effective dose was only 5. 1%–19.3% higher than the absorbed dose for individual dose cycles.

Conclusions:
Higher peptide dose of 200 μg appears to be more suitable than 90 μg in terms of tumor dose, kidney dose, and therapeutic index for treatment with 177Lu-DOTATOC.