bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potensi Kompres Hangat Jahe Merah Sebagai Terapi komplementer Terhadap Pengurangan Nyeri Artritis Gout
Authors: Anis Rahmawati  
Published: August 2021

AbstrakArtritis gout merupakan salah satu penyakit Metabolisme yang disebabkan oleh penumpukan monosodium urate monohydrate crystals pada sendi. Gejala utama yang lazim dirasakan oleh penderita gout artritis adalah nyeri sendi. Untuk mengatasi nyeri terapi farmakologi yang lazim diberikan adalah obat obatan analgesik. Penggunaan antinyeri pada penderita gout artritis yang umumnya dibutuhkan dalam jangka waktu yang panjang dan banyak yang timbulnya efek samping sehingga terapi non farmakologis diharapkan menjadi alternatif untuk mengurangi nyeri artritis gout sehingga menurunkan penggunaan obat antinyeri. Salah satu terapi komplementer untuk mengurangi nyeri gout artritis adalah terapi kompres jahe. Tujuan tinjauan pustaka ini adalah untuk mengkaji lebih dalam publikasi hasil penelitian yang berkaitan dengan terapi kompres jahe untuk mengatasi nyeri pada penderita gout artritis. Metode penulisan studi literatur ini adalah merujuk artikel publikasi pada jurnal nasional maupun internasional dengan topik terkait, meringkas, membandingkan hasil dan disajikan dalam bentuk artikel. Hasil dari penelusuran artikel publikasi yang terkait secara keseluruhan menyatakan bahwa kompres jahe hangat dapat mengurangi nyeri pada artritis gout. Kesimpulan yang dapat diambil adalah kompres jahe hangat adalah pengobatan tradisional atau terapi alternatif untuk mengurangi nyeri sendi gout.
Kata kunci : gout artritis, kompres jahe

Abstract
Gouty arthritis is a metabolic disease caused by a buildup of monosodium urate monohydrate crystals in the joints. The main symptom commonly felt by people with arthritis gout is joint pain. To deal with pain, pharmacological therapy that is commonly given is analgesic drugs. The use of painkillers in people with gouty arthritis is generally needed for a long period of time and there are many side effects so that non-pharmacological therapy is expected to be an alternative to reduce gouty arthritis pain so as to reduce the use of painkillers. One of the complementary therapies to reduce gouty arthritis pain is ginger compress therapy. The purpose of this literature review is to examine the publication of research results related to ginger compress therapy for pain management in patients with gout arthritis. The method of writing this literature study is to refer to published articles in national and international journals with related topics, summarize, compare results and present them in the form of articles. The results of the search for related published articles as a whole suggest that warm ginger compresses can reduce pain in gouty arthritis. The conclusion that can be drawn is warm ginger compress is a traditional medicine or alternative therapy to reduce gout joint pain.
Keywords: Gouty Arthritis Pain, Warm Compress, Red Ging
ANALISIS BENTUK LAYANAN HOMECARE YANG DIINGINKAN PASIEN BERDASARKAN KASUS PENYAKIT DI MASA PENDEMI COVID-19
Authors: Nugroho Christianto 
Published: August 2021

Homecare merupakan pelayanan kesehatan di rumah yang memberikan kesempatan bagi masyarakat mendapatkan pelayanan kesehatan yang maksimal. Faktor kasus penyakit terhadap bentuk layanan homecare masih memerlukan analisis lebih mendalam. Tujuan dari penelitian ini adalah menganalisis kasus penyakit terhadap bentuk layanan homecare yang diinginkan pasien pada masa pendemi covid-19 di rsud pare, kediri, jawa timur, indonesia.
Desain penelitian ini adalah cross-sectional. Populasi penelitian ini adalah semua pasien di RSUD Pare dan sampel penelitian 172 responden dengan tehnik simple random sampling. Pengumpulan data dengan kuesioner tentang bentuk layanan homecare dan kasus penyakit pasien, kemudian dilakukan analisis multivariat dengan uji regresi linear.
Hasil penelitian menunjukkkan bentuk layanan homecare berurutan sebagai berikut Perawatan 91 responden, pengobatan 54 respoden, konsultasi kesehatan 22 respoden, dan Fisoterapi 5 responden dari semua kasus penyakit yang dialami oleh pasien.
Bentuk layanan homecare dapat disimpulkan bahwa pelayanan keperawatan oleh tenaga perawat, pengobatan oleh dokter, konsultai kesehatan dan fisioterapi merupakan perpaduan yang harmonis untuk mewuudan pelayana homecare yang baik dan servis yang memuasakan bagi masyarakat, sehingga kesehatan ditengah masyarakat bisa terwujud.
IDENTIFIKASI MANFAAT LIMBAH BATANG TEMBAKAU DI KABUPATEN LOMBOK TIMUR
Authors: Anwar Muhammad , Murah  , Muhammad Zainuddin  
Published: August 2021

Post-harvest management of tobacco commodities in East Lombok Regency is very important considering that the waste of tobacco stems, leaf stalks, seeds, and residues from the oven process still contains nicotine. Efforts need to be made to treat tobacco waste so that harmful risks can be reduced by applying the concept of environmentally friendly agriculture or an eco-farming system. Environmentally friendly agriculture is part of the implementation of sustainable agriculture, which is an agricultural movement that uses ecological principles, the study of the relationship between organisms and their environment. East Lombok's local resources in the form of the availability of tobacco stem waste which is abundant, neglected, and damaging to the aesthetics of the environment requires more in-depth attention to study its benefits into various environmentally friendly products. This research was conducted using a qualitative descriptive method with a library research approach. The benefits of tobacco stem waste are as follows: Tobacco stem and stem waste as bio-biket material; Tobacco stems and seeds as biodiesel; Tobacco waste extract granules against aedes aegypti larvae; Tobacco stem waste as biopesticide material; Tobacco stem waste as organic fertilizer; Tobacco stem waste as natural dye for batik and bioinsecticide tobacco stem soaking water.
Keywords: Waste, Tobacco Stems, Eco-Farming and East Lombok
ABSTRAK
Pengelolaan pasca panen komoditas tembakau di Kabupaten Lombok Timur sangat penting dilakukan mengingat limbah batang tembakau, tangkai daun, biji, dan residu dari proses pengovenan masih mengandung nikotin. Perlu dilakukan upaya pengolahan limbah tembakau tersebut agar resiko berbahaya dapat dikurangi dengan menerapkan konsep pertanian yang ramah lingkungan atau eco-farming system. Pertanian ramah lingkungan adalah bagian dari impelementasi pertanian berkelanjutan (sustainable agriculture) yaitu gerakan pertanian yang menggunakan prinsip ekologi, studi hubungan antara organisme dan lingkungannya. Sumberdaya lokal Lombok Timur berupa tersedianya limbah batang tembakau yang melimpah, tidak terurus, dan merusak estetika lingkungan membutuhkan perhatian yang lebih mendalam untuk dikaji manfaatnya menjadi berbagai produk yang ramah lingkungan. Penelitian ini dilakukan dengan metode deskriptif kualitatif dengan pendekatan studi pustaka (library research). Manfaat limbah batang tembakau sebagai berikut: Limbah batang dan gagang (stem) tembakau sebagai bahan bio-biket; Batang dan biji tembakau sebagai biodesel; Granul ekstrak limbah tembakau terhadap larva aedes aegypti; Limbah batang tembakau sebagai bahan biopestisida; Limbah batang tembakau sebagai pupuk organik; Limbah batang tembakau sebagai pewarna alami batik dan Air rendaman batang tembakau bioinsektisida.
Kata kunci: Limbah, Batang Tembakau, Eco-Farming dan Lombok Timur
Food Consumption Pattern and Dietary Diversity among the Farmers in Kanyakumari and Perambalur Districts of Tamil Nadu
Authors: Melba Y. , Ashok K. R. , Vidhyavathi A. , Kalaivani S. , Vennila P. 
Published: August 2021

Aims: To study the consumption pattern and dietary diversity among the farmers in rural areas.
Study Design: Random Sampling.
Place and Duration of Study: Primary data were collected from the Kanyakumari and Perambalur districts of marginal and small farmers between July and August 2020.
Methodology: The study was conducted in Kanyakumari and Perambalur districts based on Tamil Nadu state planning commission report 2017.The Simpson index of dietary diversity was calculated to score the quantity and consumption of food items were consumed. The multiple linear regressions were used to understand the variation of socio-economic and demographic features of the household members.
Results: The overall result of the SIDD score for Kanyakumari district was 0.73 and 0.72 for Perambalur district. When compared to Perambalur district, the results clearly showed that Kanyakumari district farmers had a higher dietary diversity. Because the food habits of Kanyakumari district farmers differ significantly from those of Perambalur district farmers, owing to a higher intake of nutritious foods in Kanyakumari district farmers.
Conclusion: The factors like monthly income and education most influence the household dietary pattern and nutrition status of Kanyakumari district rather than the Perambalur district.
Clinical and Molecular Findings in a Moroccan Family with Primary Distal Renal Tubular Acidosis and Deafness by Mutation of ATP60A4 Gene: Case Report
Authors: Mebrouk Nadia , Abilkassem Rachid , Agadr Aomar 
Published: August 2021

Primary distal renal tubular acidosis (dRTA) is a rare genetic disease characterized by distal tubular dysfunction leading to metabolic acidosis and alkaline urine. It is associated with impaired acid excretion by the intercalated cells in the renal collecting duct. dRTA is developed during the first months of life and the main clinical and biologic features are failure to thrive, vomiting, dehydration, anorexia, hyperchloremic non-anion gap metabolic acidosis, hypocitraturia, hypercalciuria and nephrocalcinosis. The disease is caused by defects in genes involved in urinary distal acidification: ATP6V0A4 and ATP6V1B1 for the recessive form, and SLC4A1 for the dominant form. Some dRTA cases due to recessive gene mutations are associated with hearing impairment.
We report the case of two siblings with dRTA, and early-onset SNHL, due to ATP6V0A4 mutations, and whose parents are heterozygous carriers of ATP6V0A4 mutations.
In vitro Cytotoxicity and Antioxidant Study of Rhodomyrtus tomentosa (Aiton) Hassk. Ethanolic Leaf Extract on LPS-induced RAW 264.7 Macrophage Cells
Authors: Karem Azizah Ab , Kamarudin Evana , Jusril Nor Atiqah , Halim Hasseri , Hussain Roslinah Mohamad , Bahari Mazura 
Published: August 2021

Aims: Ethanol extract of Rhodomyrtus tomentosa leaves found specifically on Malaysian soil was used to further investigate the antioxidant properties and cytotoxicity against RAW 264.7 macrophage cells in the search for a safer and effective natural antioxidant agent.
Study Design: Antioxidant potential of R. tomentosa were analyzed through series of spectrometric assays and cell-based bioassays model.
Place and Duration of Study: This study was carried out at Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 43200, Selangor, Malaysia from the year of 2019 to 2021.
Methodology: R. tomentosa leaves were subjected to extraction with 95% ethanol. The extracts were then denoted as ethanolic leaves extract of R. tomentosa or EtRT extract. EtRT extract were then screen for its antioxidant activity (AOA) and total antioxidant capacity (TAC) through DPPH radical scavenging assay and ferric reducing antioxidant power (FRAP) assay. After that, EtRT extract were brought to observe its toxicity against RAW 264.7 macrophage cells in MTT assay. Once their toxicity was obtained, EtRT extracts were finally tested for their ability to inhibit intracellular reactive oxygen species (ROS) and nitric oxide (NO) inhibition in RAW 264.7 macrophage cells to further analyze their antioxidant properties.
Results: In this study, EtRT extracts dose dependently showed the ability to scavenge DPPH radicals and reduce ferric ions during DPPH radicals scavenging activity assay and ferric reducing antioxidant power assay (FRAP), respectively. In DPPH radical scavenging activity assay, EtRT extracts showed EC50 value at 12.37 ± 1.73 µg/mL with ARP value of 0.08 almost as near as ascorbic acid’s ARP value which is 0.09. Further into the study, EtRT extract were not cytotoxic to RAW 264.7 macrophage cells at concentrations 3.91 µg/mL and lower which showed more than 86.4% cell viability with IC50 value at 204.70 ± 5.30 µg/mL. EtRT extract possessed the ability to inhibit ROS production on LPS-induced RAW 264.7 macrophage cells at 7.813 µg/mL and lower, with the highest concentration can reduce up to 30.20% ± 1.01 out of the total ROS produced by the induced cells. Furthermore, EtRT extract also have evidenced that it is able to significantly inhibit NO production by the LPS-induced RAW 264.7 macrophage cells at 7 µg/mL and lower being the highest at 56.73% ± 0.11 inhibition of the highest concentration tested.
Conclusions: This study suggests that EtRT extracts have the potential to reduce LPS-induced oxidative stress due to the antioxidant activities of phenolic compounds in the extracts, and that at low doses, EtRT extracts had low to no cytotoxicity on RAW 264.7 macrophage cells. As a result, EtRT extract could be a promising natural medicinal agent for the treatment of oxidative stress.
Dynamics of Multiple Slip and Thermal Radiation on Hydromagnetic Casson Nanofluid Flow over a Nonlinear Porous Stretchable Surface
Authors: Omotola O. E. , Fatunmbi E. O. 
Published: August 2021

Aims/ Objectives: This paper examines the dynamics of multiple slip together with thermal radiation effects on the transport of a magnetohydrodynamic Casson nanofluid passing a nonlinear porous stretchable sheet in the existence of viscous dissipation and chemical reaction.Study Design: Cross-sectional study. Methodology: The outlining equations modeling the transport phenomenon are simplified into nonlinear ordinary differential equations via the approach of similarity transformations and subsequently analyzed numerically by shooting techniques alongside Runge-Kutta Fehlberg scheme.Results: The outcomes of decisive parameters affecting the flow, heat, and nanoparticle concentration are graphically deliberated. From the investigation, it is revealed that Brownian motion, viscous dissipation, and thermophoresis parameters augment the thermal boundary layer and propel an upward growth in the temperature profile. Furthermore, the slip factor decelerates the flow and heat dissipation while the fluid movement drags in the existence of the magnetic field.
Conclusion: The results obtained in this study compared favourably well with existing related studies in literature under limiting scenarios.
In-vitro Antibacterial and Synergistic Activities of Extracts of Allium cepa and Allium sativum with Selected Antibiotics on Escherichia coli and Staphylococcus aureus
Authors: I. Nnamchi Chukwudi , K. Igu Ebenezer , K. Akpi Uchenna , C. Amadi Onyetugo , Kenneth Ugwu 
Published: August 2021

Aim: This study was aimed at investigating the antibacterial activities of extracts of Allium cepa and Allium sativum, as well as their synergistic activities with some selected antibiotics against the bacterial pathogens Escherichia coli and Staphylococcus aureus.
Study Design: Onions (Allium cepa), garlic (Allium sativum) were used in this study. The study assessed how extracts of the plants alone or in combination with some commonly used antibiotics inhibited the growth of some bacterial pathogens using agar well diffusion method.
Place and Duration of Study: The research was carried out in the Department of Microbiology, University of Nigeria, Nsukka over a period of 6 months.
Methodology: Extracts of Allium cepa and Allium sativum were obtained using ethanol, methanol and water (aqueous). Antimicrobial susceptibility tests were carried out by agar well diffusion technique.
Results: All extracts obtained showed evidence of antimicrobial property measured as the Inhibition Zone Diameter (IZD) on the test microorganisms. Values of these IZDs showed remarkable increases when used synergistically with antibiotics. For instance, aqueous extract of Allium sativum increased from a mean value of 16.5mm at 1.0mg/ml to values of 30.0mm and 38.0mm when used with tetracycline and ampicloxacillin respectively against Escherichia coli. The MIC and MBC values also dropped progressively, indicating that fewer synergistic mixtures were required to exert the same effects on the tested organisms. The phytochemical analysis strongly indicated the presence of flavonoids, glycosides and alkaloids, among other plant metabolites.
Conclusion: This result indicates that Allium cepa and Allium sativum showed strong antibacterial activity against the bacterial pathogens E. coli and S. aureus; and that synergism of the extracts with some antibiotics improved those activities. The potential of developing antimicrobials from these plants appears promising.
Control of a multirobot bricklaying system
Authors: Ambrosino Michele , Delens Philippe , Garone Emanuele 
Published: August 2021

AbstractResearch is increasingly shifting from the design and control of single robots toward collaborative methods for multirobot systems. Particularly interesting are heterogeneous systems since the combination of different capabilities can tackle tasks that are difficult, if not impossible, to perform with a single robot. In this article we propose a scheme for the control of a novel heterogeneous multirobot system designed for bricklaying where the use of a single robot is not feasible due to the weight of the payloads to be managed. The proposed solution is based on a crane which cooperates with a lightweight rigid robot. The correct cooperation between the two robotic subunits poses a series of control challenges that must be studied in the context of cooperative manipulation of an object. In this article, we first derive the mathematical model of this novel robotic system during the positioning of the block. Then a control law is proposed. The proposed law is based on an ad hoc inverse dynamic control which takes advantage of the overactuation of the resulting connected system to unload the robotic arm from the weight of the block. A physical CAD‐based simulator of the system is used to show the effectiveness of the proposed control law and to show that the proposed architecture allows to position precisely large and heavy blocks while using a relatively small rigid robotic manipulator.
Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors
Authors: Burtscher Bernhard , Manco Urbina Pamela Allison , Diacci Chiara , Borghi Simone , Pinti Marcello , Cossarizza Andrea , Salvarani Carlo , Berggren Magnus , Biscarini Fabio , Simon Daniel T. , Bortolotti Carlo A. 
Published: August 2021

AbstractAn overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state‐of‐the‐art technologies—organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)—and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and “gold standard” quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT‐ and EGOFET‐based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID‐19)pandemic where one of the worst‐case scenarios for patients is the “cytokine storm.” Clearly, low‐cost point‐of‐care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.
An Optogenetics‐Inspired Flexible van der Waals Optoelectronic Synapse and its Application to a Convolutional Neural Network
Authors: Seo Seunghwan , Lee Je‐Jun , Lee Ryong‐Gyu , Kim Tae Hyung , Park Sangyong , Jung Sooyoung , Lee Hyun‐Kyu , Andreev Maksim , Lee Kyeong‐Bae , Jung Kil‐Su , Oh Seyong , Lee Ho‐Jun , Kim Ki Seok , Yeom Geun Young , Kim Yong‐Hoon , Park Jin‐Hong 
Published: August 2021

AbstractOptogenetics refers to a technique that uses light to modulate neuronal activity with a high spatiotemporal resolution, which enables the manipulation of learning and memory functions in the human brain. This strategy of controlling neuronal activity using light can be applied for the development of intelligent systems, including neuromorphic and in‐memory computing systems. Herein, a flexible van der Waals (vdW) optoelectronic synapse is reported, which is a core component of optogenetics‐inspired intelligent systems. This synapse is fabricated on 2D vdW layered rhenium disulfide (ReS2) that features an inherent photosensitive memory nature derived from the persistent photoconductivity (PPC) effect, successfully mimicking the dynamics of biological synapses. Based on first‐principles calculations, the PPC effect is identified to originate from sulfur vacancies in ReS2 that have an inherent tendency to form shallow defect states near the conduction band edges and under optical excitation lead to large lattice relaxation. Finally, the feasibility of applying the synapses in optogenetics‐inspired intelligent systems is demonstrated via training and inference tasks for the CIFAR‐10 dataset using a convolutional neural network composed of vdW optoelectronic synapse devices.
Triple‐Jump Photodynamic Theranostics: MnO2 Combined Upconversion Nanoplatforms Involving a Type‐I Photosensitizer with Aggregation‐Induced Emission Characteristics for Potent Cancer Treatment
Authors: Wang Yuanwei , Li Youmei , Zhang Zhijun , Wang Lei , Wang Dong , Tang Ben Zhong 
Published: August 2021

AbstractThe development of multifunctional nanoplatforms has been recognized as a promising strategy for potent photodynamic theranostics. Aggregation‐induced emission (AIE) photosensitizers undergoing Type‐I reactive oxygen species (ROS) generation pathway appear as potential candidates due to their capability of hypoxia‐tolerance, efficient ROS production, and fluorescence imaging navigation. To further improve their performance, a facile and universal method of constructing a type of glutathione (GSH)‐depleting and near‐infrared (NIR)‐regulated nanoplatform for dual‐modal imaging‐guided photodynamic therapy (PDT) is presented. The nanoplatforms are obtained through the coprecipitation process involving upconversion nanoparticles (UCNPs) and AIE‐active photosensitizers, followed by in situ generation of MnO2 as the outer shell. The introduction of UCNPs actualizes the NIR‐activation of AIE‐active photosensitizers to produce ·OH as a Type‐I ROS. Intracellular upregulated GSH‐responsive decomposition of the MnO2 shell to Mn2+ realizes GSH‐depletion, which is a distinctive approach for elevating intracellular ·OH. Meanwhile, the generated Mn2+ can implement T1‐weighted magnetic resonance imaging (MRI) in specific tumor sites, and mediate the conversion of intracellular H2O2 to ·OH. These outputs reveal a triple‐jump ·OH production, and this approach brings about distinguished performance in FLI‐MRI‐guided PDT with high‐efficacy, which presents great potential for future clinical translations.