bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Predictors of Mental Health Outcomes Among Survivors of Adolescent and Young Adult Cancer: A Population-Based Study Using the IMPACT Cohort
Authors: De Riddhita , Sutradhar Rinku , Kurdyak Paul , Aktar Suriya , Pole Jason D. , Baxter Nancy , Nathan Paul C. , Gupta Sumit 
Published: January 2021

PURPOSE Risk and predictors of long-term mental health outcomes in survivors of adolescent and young adult (AYA) cancers are poorly characterized. Mental health is consequently neglected in long-term follow-up. METHODS We identified all AYA in Ontario, Canada age 15-21 years when diagnosed with one of six common cancers between 1992-2012 using a population-based database, and compared them with matched controls. Linkage to provincial healthcare data allowed analysis of rates of outpatient (family physician and psychiatrist) visits for psychiatric indications and time to severe psychiatric events (emergency room visit, hospitalization, and suicide). Demographic-, disease-, and treatment-related predictors of adverse outcomes, including treatment setting (adult v pediatric), were examined. RESULTS Among 2,208 survivors and 10,457 matched controls, 5-year survivors experienced higher rates of outpatient mental health visits than controls (671 visits per 1,000 person-years v 506; adjusted rate ratio [RR] 1.3; 95% CI, 1.1 to 1.5; P = .006). Risk of a severe psychiatric episode was also increased among survivors (adjusted hazard ratio [HR], 1.2; 95% CI, 1.1 to 1.4, P = .008). Risk of a psychotic disorder–associated severe event was doubled in survivors (HR, 2.0, 95% CI, 1.3 to 2.4; P = .007) although absolute risk remained low (15-year cumulative incidence 1.7%; 95% CI, 1.0 to 2.7). In multivariable analysis, survivors treated in adult centers experienced substantially higher outpatient visit rates compared with those treated in pediatric settings (RR 1.8; 95% CI, 1.0 to 3.1; P = .04). CONCLUSION Survivors of AYA cancer are at substantially increased risk of adverse mental health outcomes, with those treated in adult centers at particular risk. Although absolute incidence was low, survivors were at increased risk of psychotic disorder–associated severe events. Long-term mental health surveillance is warranted, as is research into effective interventions during or after cancer treatment.
Ceramides mediate positional signals in Arabidopsis thaliana protoderm differentiation
Authors: Nagata Kenji , Ishikawa Toshiki , Kawai-Yamada Maki , Takahashi Taku , Abe Mitsutomo 
Published: January 2021

ABSTRACT
The differentiation of distinct cell types in appropriate patterns is a fundamental process in the development of multicellular organisms. In Arabidopsis thaliana, protoderm/epidermis differentiates as a single cell layer at the outermost position. However, little is known about the molecular nature of the positional signals that achieve correct epidermal cell differentiation. Here, we propose that very-long-chain fatty acid-containing ceramides (VLCFA-Cers) mediate positional signals by stimulating the function of ARABIDOPSIS THALIANA MERISTEM LAYER1 (ATML1), a master regulator of protoderm/epidermis differentiation, during lateral root development. We show that VLCFA-Cers, which are synthesized predominantly in the outermost cells, bind to the lipid-binding domain of ATML1. Importantly, this cell type-specific protein-lipid association alters the activity of ATML1 protein and consequently restricts its expression to the protoderm/epidermis through a transcriptional feedback loop. Furthermore, establishment of a compartment, enriched with VLCFA-containing sphingolipids, at the outer lateral membrane facing the external environment may function as a determinant of protodermal cell fate. Taken together, our results indicate that VLCFA-Cers play a pivotal role in directing protoderm/epidermis differentiation by mediating positional signals to ATML1.
This article has an associated ‘The people behind the papers’ interview.
Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage
Authors: Kerjouan Adèle , Boyault Cyril , Oddou Christiane , Hiriart-Bryant Edwige , Grichine Alexei , Kraut Alexandra , Pezet Mylène , Balland Martial , Faurobert Eva , Bonnet Isabelle , Coute Yohann , Fourcade Bertrand , Albiges-Rizo Corinne , Destaing Olivier 
Published: January 2021

ABSTRACT
Upon activation by different transmembrane receptors, the same signaling protein can induce distinct cellular responses. A way to decipher the mechanisms of such pleiotropic signaling activity is to directly manipulate the decision-making activity that supports the selection between distinct cellular responses. We developed an optogenetic probe (optoSRC) to control SRC signaling, an example of a pleiotropic signaling node, and we demonstrated its ability to generate different acto-adhesive structures (lamellipodia or invadosomes) upon distinct spatio-temporal control of SRC kinase activity. The occurrence of each acto-adhesive structure was simply dictated by the dynamics of optoSRC nanoclusters in adhesive sites, which were dependent on the SH3 and Unique domains of the protein. The different decision-making events regulated by optoSRC dynamics induced distinct downstream signaling pathways, which we characterized using time-resolved proteomic and network analyses. Collectively, by manipulating the molecular mobility of SRC kinase activity, these experiments reveal the pleiotropy-encoding mechanism of SRC signaling.
Association between 18F-FDG metabolic activity and programmed death ligand-1 (PD-L1) expression using 22C3 immunohistochemistry assays in non-small cell lung cancer (NSCLC) resection specimens
Authors: Zhao Long , Liu Jinjun , Wang Huoqiang , Shi Jingyun 
Published: January 2021

Objective:
This study sought to investigate the association between 18F-fludeoxyglucose (18F-FDG) uptake in positron emission tomography/CT (PET/CT) scans and different programmed death ligand-1 (PD-L1) expression conditions in non-small cell lung cancer (NSCLC).

Methods:
From October 2017 to December 2019, NSCLC was retrospectively identified in 419 consecutive patients who underwent 18F-FDG PET/CT scans and PD-L1 expression tests using the PD-L1 22C3 assay. The association between clinicopathological characteristics and PD-L1 expression was assessed.

Results:
The frequency of PD-L1-positive tumours was 38.2% (160/419) in NSCLC. In NSCLC, the multivariate analysis showed a high maximum standardised uptake value (SUVmax) (p &lt; 0.0001) and an EGFR wild type genotype (p = 0.027) was significantly associated with PD-L1-positivity. In adenocarcinoma (ADC), the multivariate analysis showed that a high SUVmax (p &lt; 0.0001) was significantly associated with PD-L1-positivity. In NSCLC and ADC, a Mann–Whitney U test showed significant differences between groups with PD-L1 high expression and PD-L1 low expression levels in terms of SUVmax (p = 0.011 and p = 0.013, respectively). The results of the receiver operating characteristic curve analysis showed that the area under the curve of the SUVmax was 0.767 (95% CI, 0.720–0.814; p &lt; 0.0001) and 0.712 (95% CI, 0.651–0.774; p &lt; 0.0001) in NSCLC and ADC, respectively.

Conclusion:
The study demonstrates that the SUVmax was significantly associated with PD-L1 expression in NSCLC and ADC. The SUVmax was significantly different between the PD-L1 high and low expression conditions, as quantified using a PD-L1 22C3 assay.

Advances in knowledge:
This study provides direct evidence that SUVmax as a metabolic biomarker may help select patients with NSCLC likely to benefit from pembrolizumab.
IMPACT-Scot 2 report on COVID-19 in hip fracture patients
Authors: Hall Andrew J. , Clement Nick D. , MacLullich Alasdair M. J. , White Tim O. , Duckworth Andrew D. 
Published: January 2021

Aims The primary aim was to determine the influence of COVID-19 on 30-day mortality following hip fracture. Secondary aims were to determine predictors of COVID-19 status on presentation and later in the admission; the rate of hospital acquired COVID-19; and the predictive value of negative swabs on admission. Methods A nationwide multicentre retrospective cohort study was conducted of all patients presenting with a hip fracture to 17 Scottish centres in March and April 2020. Demographics, presentation blood tests, COVID-19 status, Nottingham Hip Fracture Score, management, length of stay, and 30-day mortality were recorded. Results In all, 78/833 (9.4%) patients were diagnosed with COVID-19. The 30-day survival of patients with COVID-19 was significantly lower than for those without (65.4% vs 91%; p < 0.001). Diagnosis of COVID-19 within seven days of admission (likely community acquired) was independently associated with male sex (odds ratio (OR) 2.34, p = 0.040, confidence interval (CI) 1.04 to 5.25) and symptoms of COVID-19 (OR 15.56, CI 6.61 to 36.60, p < 0.001). Diagnosis of COVID-19 made between seven and 30 days of admission to hospital (likely hospital acquired) was independently associated with male sex (OR 1.73, CI 1.05 to 2.87, p = 0.032), Nottingham Hip Fracture Score ≥ 7 (OR 1.91, CI 1.09 to 3.34, p = 0.024), pulmonary disease (OR 1.68, CI 1.00 to 2.81, p = 0.049), American Society of Anesthesiologists (ASA) grade ≥ 3 (OR 2.37, CI 1.13 to 4.97, p = 0.022), and length of stay ≥ nine days (OR 1.98, CI 1.18 to 3.31, p = 0.009). A total of 38 (58.5%) COVID-19 cases were probably hospital acquired infections. The false-negative rate of a negative swab on admission was 0% in asymptomatic patients and 2.9% in symptomatic patients. Conclusion COVID-19 was independently associated with a three times increased 30-day mortality rate. Nosocomial transmission may have accounted for approximately half of all cases during the first wave of the pandemic. Identification of risk factors for having COVID-19 on admission or acquiring COVID-19 in hospital may guide pathways for isolating or shielding patients respectively. Length of stay was the only modifiable risk factor, which emphasizes the importance of high-quality and timely care in this patient group. Cite this article: Bone Joint J 2021;103-B(5):888–897.
Pediatric Simple Knee Value: A simple patient-reported outcome measure for the knee
Authors: Marot Vincent , Vilette Hugo , Dalmas Yoann , Justo Arthur , Reina Nicolas , Cavaignac Etienne , Berard Emilie , Accadbled Franck 
Published: January 2021

Purpose The pediatric Simple Knee Value (pedi-SKV) is an outcome score in which paediatric patients are asked ‘How would you rate your knee today as a percentage of normal (0% to 100% scale with 100% being normal)?’. The primary aim of this study was to validate the pedi-SKV by measuring its correlation with validated knee function scores used most often in paediatric orthopaedics. Methods This prospective study was conducted at a teaching hospital to evaluate the pedi-SKV's validity. A total of 44 paediatric patients (ten to 15 years old), were enrolled prior to anterior cruciate ligament reconstruction as well as 17 healthy controls. A survey form consisting of the Lysholm, International Knee Documentation Committee Pediatric Form (Pedi-IKDC) and pedi-SKV was given to subjects twice (enrolment and six months postoperatively). The criterion validity of the pedi-SKV was determined by correlating it to existing knee functional scores. Responsiveness to change was evaluated by comparing the pedi-SKV scores before and after surgery (enrolment visit and six-month postoperative visit). Discriminative ability was evaluated by comparing the pedi-SKV distribution in patients versus controls. Results There was a strong and significant correlation between the pedi-SKV and the Lysholm and Pedi-IKDC (p < 0.0001). The pedi-SKV had a good responsiveness to change (p < 0.0001 for the pedi-SKV before versus six months postoperatively). Like the other knee-specific functional sores (p < 0.0001), the pedi-SKV was able to distinguish between patients and controls (p < 0.0001). Conclusion The pedi-SKV is a valid outcome measure that is strongly correlated with the Lysholm and Pedi-IKDC. This is a novel simple score that can be used by physicians in their daily practice. Level of evidence II
Activated Bentonite Modified-Carbon Paste Electrode for Determination The Level of Copper Ion (Cu2+) in Tomato
Authors: Irdhawati Irdhawati , Inur Ingtyas Mawarni Ekki , Jyostosya Yotirani Arya Wijana Ayu , Silvia Sitio Feby , Gita Widi Saraswati Ni Putu , Sahara Emmy 
Published: January 2021

Voltammetry is an electroanalytical method measure current as a function of applied potential. The working electrode in the voltammetry method dramatically affects the result of the electrochemical analysis. Modification of the working electrode can improve measurement performance. In this research, the carbon paste electrode (CPE) was modified with Bentonite (CPEB) to determine copper's level using differential pulse voltammetry technique. CPE and CPEB were used as working electrodes, handmade Ag/AgCl as a reference electrode, and Pt wire as the counter electrode. The measurement parameters were optimized, including the composition of bentonite in carbon paste and scan rates. Furthermore, the measurement conditions were validated, involved linear concentration range, detection limit (LoD), the limit of quantization (LoQ), repeatability, and recovery. The results showed that bentonite's optimum composition was 40% of the total weight of graphite and activated bentonite. The scan rate optimum for Cu2+ measurement was obtained at 20 mV/s with CPE and became faster to be 25 mV/s with CPEB. The linearity of the standard solution measurement of Cu2+ using CPE was in the range of 5 to 100 μg/L and changed to 5 to 500 μg/L using CPEB. LoD and LoQ values of standard solution Cu2+ measurement with CPEB were slower than CPE. The Horwitz ratio calculation was smaller than two for both CPE and CPEB. The recovery of Cu2+ standard measure in sample solution as the matrix was obtained 93,49 ± 6,39%. According to the Decree of the Ministry of Health Number, the level of Cu2+ in the tomato sample was found 6.019 ± 0.69 mg/kg, which is over than threshold value of Cu2+ (5 mg/kg) 03725/B/SK/VII/89.
Land Arrangement for Citronella (Cymbopogon Nardus) and Arabica Coffee in the Cultivation Area in Gayo Lues District, Aceh Province Indonesia: A Land Suitability Approach
Authors: Karim Abubakar , Sugianto Sugianto , Fazlina Yulia Dewi , Rusdi Muhammad , Manfarizah Manfarizah , Hifnalisa Hifnalisa 
Published: January 2021

Gayo Lues District is known as Citronella and Arabica coffee producer in Aceh province, Indonesia. This paper aims to manage Citronella and Arabica coffee's land arrangement in the Gayo Lues District's cultivated area. This implementation is aimed at maintaining the peculiarities of citronella products and Arabica coffee. Thus, the two commodities must be separated in terms of allocated sites. The altitude for the area is 200-2,000 meters above sea level, consisting of ten classes, and the type of soils are Entisols, Oxisols, Inceptisols, and Ultisols. The area's slope between 0- to 40% (4 classes) was used to delineate the land units. There are 49 land units observed within the cultivated area of 160,017.17 ha. The guidelines for land suitability classification by the Ministry of Agriculture for Citronella and Center for Coffee and Cocoa Research, Jember for Arabica coffee were utilized. The results showed that 58,275.5 hectares of land were suitable for citronella, and 13,765.75 ha has been planted. The actual land suitability of citronella inside the area of 58,275.5 ha is suitable (S2 class) and marginally suitable (S3-class) and not suitable (N-class) with limiting factors are temperature, water availability, erosion hazard, and nutrient retention. This land suitability can be improved by providing inputs to increase the level of suitability with temperature, water availability, and erosion hazard (slope) limiting factors. Also, 48,765.3 hectares can be developed for Arabica coffee, and 4,653.5 ha has been planted. The actual land suitability for Arabica coffee is Suitable, Marginal Suitable, and Not Suitable, limiting the soil's physical properties (adequate soil depth), slope, and chemical properties of the soil. Once repaired, the land's suitability becomes Suitable (S1-class) (without limiting factor), Suitable, and marginal suitable with the slope as a limiting factor. There is an area of 44,509.75 hectares of land at 200-1,400 m above sea level within the cultivation area developed with a Citronella. There is an area of 44,111.8 ha at the height of 800-2,000 m above sea level, potentially for Arabica coffee.
Reconfigurable electromagnetically induced transparency metamaterial simultaneously coupled with the incident electric and magnetic fields
Authors: Li Fenying , Mao Mingyu , Zhang Tao , Chen Quanfang , Li Haiming , Zhang Haifeng 
Published: January 2021

In this paper, an electromagnetically induced transparency metamaterial simultaneously coupled with the incident electric and magnetic fields is designed and presented theoretically, whereas its reconfigurability, slow-wave effect, low-loss, and polarization insensitivity are analyzed and discussed principally. Based on the tunable solid-state plasma, there is a transmission peak with a 92.06% transmission at 0.544 THz in State 1 and a transmission peak with a 92.84% transmission at 0.7535 THz in State 2, thus achieving a frequency shift of 0.2085 THz. The maximum group delay, group index, and delay-bandwidth product in State 1 or 2, which are 723.7 ps or 494.7 ps, 1024.1 or 700.1, and 48.5 or 36.1, respectively, and the excellent slow-wave effects are discussed. In addition, the low-loss and polarization insensitivity are realized by rotating the split-ring resonators 180° and twisting the planar structure 90°. Considering the unique features of the designed metamaterial, it can be extensively applied to slow-light devices, communication, sensors, and nonlinear devices.
Thin-disk laser system operating above 10  kW at near fundamental mode beam quality
Authors: Nagel Simon , Metzger Bernd , Bauer Dominik , Dominik Johanna , Gottwald Tina , Kuhn Vincent , Killi Alexander , Dekorsy Thomas , Schad Sven-Silvius 
Published: January 2021

We report on a thin-disk laser system with more than 10 kW of output power and a beam quality of

M

2

=
1.76

at an overall optical-to-optical efficiency of 51%. The system consists of two thin-disk laser oscillators and a thin-disk multi-pass amplifier system. To reach high output powers while maintaining good beam quality, the output beams of two identical laser oscillators are polarization-combined. Subsequently, the beam is amplified in a multi-pass system. To the best of our knowledge, this is the highest output power achieved for a thin-disk laser system with a beam quality close to fundamental mode.
Spectral broadening of 112  mJ, 1.3  ps pulses at 5  kHz in a LG10 multipass cell with compressibility to 37  fs
Authors: Kaumanns Martin , Kormin Dmitrii , Nubbemeyer Thomas , Pervak Vladimir , Karsch Stefan 
Published: January 2021

The first-order helical Laguerre–Gaussian mode (also called donut mode) is used to improve the energy throughput of nonlinear spectral broadening in gas-filled multipass cells. The method proposed in this Letter enables, for the first time to the best of our knowledge, the nonlinear spectral broadening of pulses with energies beyond 100 mJ and is suitable for an average power of more than 500 W while conserving an excellent spatio-spectral homogeneity of

∼

98
%

and a Gaussian-like focus profile. Additionally compressibility from 1.3 ps to 37 fs is demonstrated.
Inverse design of multi-band and wideband waveguide crossings
Authors: Yi Dan , Zhou Wen , Zhang Yaojing , Tsang Hon Ki 
Published: January 2021

Photonic integrated circuits for wideband and multi-band optical communications will need waveguide crossings that operate at all the wavelengths required by the system. In this Letter, we use the modified gradient decedent method to optimize the dual-wavelength band (DWB) crossings on both single- and double-level platforms. On the single-level platform, the simulation results show insertion losses (ILs) less than 0.07 and 0.11 dB for a crossing working at a DWB of 1.5–1.6 and 1.95–2.05 µm. ILs are less than 0.1 and 0.2 dB for a crossing operating in the DWB of 1.5–1.6 and 2.2–2.3 µm. On the double-layer platform, the simulated results show IL less than 0.08 dB across the wavelength range of 1.25–2.25 µm. We experimentally demonstrate the DWB crossing operating at 1.5–1.6 and 2.2–2.3 µm to have IL less than 0.3 and 0.4 dB and crosstalk of

−

28

and

−

26

d
B

in the two bands, respectively.
Simultaneous generation of the second- and third-order OAM modes by using a high-order helical long-period fiber grating
Authors: Detani Taishu , Zhao Hua , Wang Peng , Suzuki Taiga , Li Hongpu 
Published: January 2021

An all-fiber orbital angular momentum (OAM) mode generator enabling simultaneous generation of the second- and the third-order OAM modes with conversion efficiencies larger than 95% has been proposed and experimentally demonstrated, which is realized by using a high-order helical long-period fiber grating (HLPG) written in a thinned four-mode fiber. This is the first time, to the best of our knowledge, that two such OAM modes have been simultaneously obtained at wavelengths ranging from 1450 to 1620 nm by using only one fiber component, i.e., the HLPG. The proposed method provides a new way to simultaneously generate different orders of the OAM modes, which would further expand the OAM’s applications to the fields of the optical tweezers, microscopy, and fiber communication, etc.
PASA: Proteomic analysis of serum antibodies web server
Authors: Avram Oren , Kigel Aya , Vaisman-Mentesh Anna , Kligsberg Sharon , Rosenstein Shai , Dror Yael , Pupko Tal , Wine Yariv 
Published: January 2021

Motivation
A comprehensive characterization of the humoral response towards a specific antigen requires quantification of the B-cell receptor repertoire by next-generation sequencing (BCR-Seq), as well as the analysis of serum antibodies against this antigen, using proteomics. The proteomic analysis is challenging since it necessitates the mapping of antigen-specific peptides to individual B-cell clones.

Results
The PASA web server provides a robust computational platform for the analysis and integration of data obtained from proteomics of serum antibodies. PASA maps peptides derived from antibodies raised against a specific antigen to corresponding antibody sequences. It then analyzes and integrates proteomics and BCR-Seq data, thus providing a comprehensive characterization of the humoral response. The PASA web server is freely available at https://pasa.tau.ac.il and open to all users without a login requirement.