bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalencia de anemia en pacientes hospitalizados en el Centenario Hospital Miguel Hidalgo de la Ciudad de Aguascalientes
Authors: Rosas-Cabral A , Álvarez-Solís B E , Salazar-Gutiérrez R , Olvera-Herrera E , Hernández-Flores R , Hernández-Ortega B , Torres-Bernal L F , Terrones-Saldívar M C 
Published: March 2021

La presencia de anemia es un factor importante que agrega morbilidad y mortalidad a los pacientes hospitalizados de manera independiente a la patología que condicionó el internamiento, y por ello debe ser estudiada y tratada en forma concomitante a la causa de la hospitalización. La Organización Mundial de la Salud define anemia como una concentración de hemoglobina sérica menor de 12 g/dL en mujeres y de 13 g/dL en hombres. En México, existen escasos reportes sobre la frecuencia de pacientes hospitalizados que cursan con anemia y sobre el origen de la misma. Material y métodos: Se realizó un estudio descriptivo, prospectivo y transversal en 1091 pacientes hospitalizados del Centenario Hospital Miguel Hidalgo de la Ciudad de Aguascalientes para determinar la prevalencia de anemia y el tipo morfológico más frecuente de ésta. Resultados. Encontramos una prevalencia de anemia del 39.23% con predominio en pacientes masculinos. El tipo de anemia más frecuente fue del tipo normocítica y normocrómica con anisocitosis. Conclusión. Este hallazgo nos permitió confirmar que la anemia es un padecimiento con una elevada prevalencia en pacientes hospitalizados en nuestro medio y que por tal razón debe ser un factor a considerar en la evolución del padecimiento de base que propicio la hospitalización del paciente.
Efektifitas Promosi Kesehatan Dalam Deteksi Dini Ca Mammae pada Remaja
Authors: Susanti Rosa , Zulaika Zulaika 
Published: March 2021

Angka kejadian penyakit kanker di Indonesia berada pada urutan ke-8 di Asia Tenggara, sedangkan di Asia berada pada urutan ke-23. Di Indonesia Angka kejadian tertinggi untuk perempuan adalah kanker payudara sebesar 42,1/100.000 penduduk dengan rata-rata kematian 17 /100.000. Promosi kesehatan merupakan upaya yang dapat dilakukan untuk menyebarluaskan informasi mengenai deteksi dini ca mammae. Tujuan pada penelitian ini untuk mengetahui efektifitas promosi kesehatan dalam deteksi dini Ca Mammae pada remaja dengan menggunakan video, leafleat dan tanpa media. Populasi pada penelitian ini adalah siswi SMKN 57, jumlah sampel sebanyak 90 siswi kelas X,XI,XII, dimana setiap kelompok berjumlah 30 responden. Data dianalisa dengan uji peringkat bertanda welcoxon, Uji T berpasangan (T-Paired) dan regresi linier. Hasil penelitian ini menunjukan bahwa terdapat pengaruh penggunaan media video (Pv=0,024), leaflet (Pv=0,000) dan tanpa menggunakan media (Pv=0,003). Uji F menunjukkan nilai Pv=0,005, yang berarti ketiga variabel tersebut secara signifikan dapat untuk memprediksi variable efektifitas media. Promosi kesehatan dengan menggunakan media video dan leaflet sangat efektif begitu juga dengan tanpa menggunkan media (Video & Leafleat).
Efek Kepemimpinan Spiritual Terhadap Peningkatan Kinerja Sumber Daya Manusia dan Organisasi di Puskesmas Kota Kendari
Authors: Azlimin Azlimin , Juslan Juslan 
Published: March 2021

Pegawai sering menderita keterasingan antarpribadi dan kelelahan di tempat kerja. Spiritualitas adalah sebuah proses dalam kehidupan individu, berupa makna dan tujuan, dan semuanya berdampak pada individu lain dan lingkungannya, termasuk organisasi Puskesmas. Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan spiritual terhadap peningkatan kinerja SDM dan Organisasi puskesmas di Kota Kendari. Teknik pengumpulan data dilakukan dengan pengamatan, wawancara, dan pengumpulan data sekunder. Data dianalisis menggunakan metode kuantitatif. Responden penelitian adalah pegawai Puskesmas yang ditentukan secara proposional random sampling. Responden dalam penelitian ini berjumlah 61 sampel. Analisis data menggunakan metode SEM dengan sofware SmartPLS 3.0. Teknik pengumpulan data menggunakan kuesioner dengan skala likert. Hasil penelitian menunjukkan bahwa kepemimpinan spiritual berpengaruh positif terhadap kinerja sumber daya manusia (T-statistik=10,181≥1,989; Pv=0,000) dan kinerja organisasi (T-statistik=23,426≥1,989; Pv=0,000). Diharapkan pengambil kebijakan dan pimpinan puskesmas untuk meningkatkan meningkatkan kemampuan organisasi bersifat hierarkis: memanamkan kayakinan dan harapan kepada semua sumber daya manusia sehingga dalam menjalankan tugas pokok dan fungsi dapt dilakukan dengan penuh keyakinan.
Individual Monitoring of Internal Exposure for Nuclear Medicine Workers in NINMAS through In-Vitro Bioassay Techniques
Authors: Shubho Mahadee Hasan , Prodhan Md Mahidul Haque , Begum Ferdoushi , Sahadath Md Hossain , Hossain Md Zakir , Ferdous Jannatul 
Published: March 2021

Internal radiation monitoring of occupational radiation workers is essential for protecting them against the risks of incorporated radionuclides. More than 400 workers in Bangladesh are working with unsealed radioactive sources and most of them are employed at different nuclear facilities. Among the 18 Nuclear Medicine Centers in the country, the National Institute of Nuclear Medicine and Allied Science (NINMAS), Dhaka was selected for this study where workers get internal radiation exposure while processing and labeling of the liquid sources. The aim of this study was to estimate the activity concentration and committed effective doses from bioassay sample, namely urine samples of Nuclear Medicine (NM) workers due to handling of radioactive Iodine (131I), Technetium (99mTc) and Fluorine (F-18). Total 86 urine samples were collected from 17 occupational workers of NINMAS during the year 2017 and analyzed using High Purity Germanium (HPGe) detector. The radioactivity of 131I and (99mTc) was found 2.21±0.44 BqL-1 to 444 ± 39.91 BqL-1 and 5.53±1.12 BqL-1 to 603 ± 72.36 BqL-1 respectively. Due to low activity of the unsealed F-18 sources and for appropriate shielding, radioactivity of F-18 was found below the minimum detection level in the urine samples of the workers who handled it. The effective doses of occupational workers have also been calculated using the radioactivity concentration and the dose coefficients given in ICRP publication 78. The highest and lowest effective doses due to handling of the unsealed source of (99mTc) were 28.2 and 0.0258μSv for working with 780 and 36mCi of radionuclide respectively. On the other hand, the highest and lowest effective doses due to handling of 131I were 8.73and 0.045μSv, for working with 1425 and 55 mCi respectively. Both the doses are found to comply with ICRP annual dose limit of 20 mSv.
Bangladesh J. Nuclear Med. 22(2): 125-129, Jul 2019
Congenital left lobe megaly of liver resembling splenic pathology: a diagnostic dilemma confirmed bySPECT-CT of liver-spleen scan
Authors: Bhattacharjee Puja , Mandal Tapati , Quddus Sharmin , Mutsuddi Pupree , Akhter Papia , Islam Md Azharul , Md Ismail - , Siddique Abu Bakker , Islam Reajul , Haque Jasmine Ara 
Published: March 2021

Liver scintigraphy is a specialized nuclear medicine imaging technique used to diagnose hepatic pathological conditions as well as to assess the function of the liver. Itis also used to follow the progress of treatment of certain diseases. This procedure may be referred as liver-spleen scan because the spleen is alsoevaluateddue to its proximity and close functional relationship to liver.SPECT-CT correlation along with planar images increases the specificity of the test and can guide the physicians to rule outdiagnostic dilemma regarding certain hepatic & splenic diseases. Here, we present a case where the patient was initially suspected tohave splenomegaly with splenic hematomabut finally confirmedas unusuallyenlarged left lobe of liverand normal sized spleen with SPECT-CT of liver-spleen scan.
Bangladesh J. Nuclear Med. 22(2): 161-165, Jul 2019
Environmental changes and general health condition
Authors: Islam Nabhira Aftabi Binte , Uddin Nasir , Sultana Hafiza 
Published: March 2021

Background: The environment directly affects health status and plays a major role in quality of life, years of healthy life lived, and health disparities. Humans impact the physical environment in many ways, like over population, pollution, burning fossil fuels, and deforestation. The study was conducted to assess environmental changes and the general health condition.
Methods: It was a cross-sectional study. To assess environmental changes and general health condition of dental second year student and data were collected by checklist. Respondents were selected purposively. Data were collected on 8th September 2019 at Marks medical college dental unit. Samples were second year dental students, who were presented in class on that date.
Results: Distribution of the respondents according to sex, 64.5% were female and 35.5% male. Majority of the student (51.6%) were come from outside of the Dhaka. 45.2% respondents were lived in Dhaka by born. 80.6% respondents lived with their family. It was alarming that 83.9% respondents never did physical exercise and only 16.1% did sometimes physical exercise. 61.3% respondent admired that they have hair loss, 16.1% has no problems in skin but others has problems. 51 .6% has dust, 1 2.9% has food allergy. 6.5 % has frequently exposure of diarrhea diseases. Often 67.7% has been suffered by headache. Reason of seasonal changes 29% respondents suffered by itching. 77.4% and 83 .9% respondents were affected by anxiety and depression. 77.4% respondent has knowledge about weather change in our country as well as whole world.
Conclusion: General health condition maybe changed for multiple causes. Environment is one of the strong factors. The relation between environmental temperature and health has been known for a very long time.
JOPSOM 2020; 39(1): 73-77
Serum Lipid Levels and Treatment Outcomes in Women Undergoing Assisted Reproduction: A Retrospective Cohort Study
Authors: Cai Wang-Yu , Luo Xi , Chen Erxidi , Lv Houyi , Fu Kaiyou , Wu Xiao-Ke , Xu Jian 
Published: March 2021

ObjectiveTo evaluate associations between serum lipid levels and treatment outcomes in women undergoing assisted reproduction.Materials and MethodsThe study included 2011 women who underwent in vitro fertilization/intracytoplasmic sperm injection with fresh embryo transfer. Serum lipid evaluation included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Ovarian stimulation outcomes included endometrial thickness and the number of oocytes retrieved, and reproductive outcomes included live birth, clinical pregnancy, and miscarriage.ResultsHigher HDL-C quartiles were associated with more oocytes retrieved. Lower TC (quartile 1 odds ratio [OR] 1.59 [1.21–2.08], quartile 3 OR 1.36 [1.04–1.77]), LDL-C (quartile 1 OR 1.41 [1.07–1.86]), and TG (quartile 2 OR 1.39 [1.06–1.84]) were independently associated with clinical pregnancy after adjusting for potential confounders. Lower LDL-C (quartile 1 OR 2.22 [1.58–3.13], quartile 2 OR 1.78 [1.27–2.50], quartile 3 OR 1.51 [1.07–2.13]), TC (quartile 1 OR 1.39 [1.00–1.93]), TG (quartile 1 OR 1.44 [1.03–2.03], quartile 2 OR 1.46 [1.04–2.04], quartile 3 OR 1.44 [1.04–1.99]), and higher HDL-C (quartile 2 OR 0.71 [0.51–0.99]) were independently associated with live birth. Higher LDL-C (quartile 1 OR 0.44 [0.30–0.66], quartile 2 OR 0.49 [0.33–0.73], quartile 3 OR 0.63 [0.43–0.94]) and lower HDL-C (quartile 1 OR 1.60 [1.07–2.39]) were independently associated with miscarriage.ConclusionsSerum lipid levels were associated with treatment outcomes in women undergoing assisted reproduction.
Differential Effects of Serum Lipoprotein-Associated Phospholipase A2 on Periventricular and Deep Subcortical White Matter Hyperintensity in Brain
Authors: Jiang Junying , Gao Yuanyuan , Zhang Rui , Wang Lin , Zhao Xiaoyuan , Dai Qi , Zhang Wei , Xu Xiujian , Chen Xuemei 
Published: March 2021

Background and Purpose: Serum level of lipoprotein-associated phospholipase A2 (Lp-PLA2) was associated with white matter hyperintensity (WMH). There were differences in the anatomical structure and pathophysiological mechanism between periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH). In this study, we aimed to investigate the effects of serum Lp-PLA2 on the PVWMH and DSWMH.Methods: In total, 711 Chinese adults aged ≥45 years with cranial magnetic resonance imaging (MRI) were recruited in this cross-sectional study, who had received physical examinations in the Department of Neurology, the Affiliated Jiangning Hospital of Nanjing Medical University due to dizziness and headaches between January 2016 and July 2019. Enzyme linked immunosorbent assay (ELISA) was utilized to determine the serum Lp-PLA2. Fazekas scale was used to measure the severity of PVWMH (grade 0–3) and DSWMH (grade 0–3) on MRI scans. Ordinal regression analysis was carried out to investigate the relationship between serum Lp-PLA2 and PVWMH or DSWMH.Results: Finally, 567 cases were included in this study. The average level of serum Lp-PLA2 was 213.35±59.34 ng/ml. There were statistical differences in the age, hypertension, diabetes mellitus, atrial fibrillation, lacunar infarction, Lp-PLA2 grade, creatinine, Hcy, and H-CRP (P &lt; 0.05) in PVWMH groups. Ordinal regression analysis indicated that there was a lower risk of PVWMH in the patients with normal and moderately elevated serum Lp-PLA2 compared with those with significantly elevated serum Lp-PLA2 after adjusting age, hypertension, diabetes mellitus, atrial fibrillation, lacunar infarction, Cr, Hcy, and H-CRP. In addition, PVWMH was correlated to advanced age, hypertension, diabetes mellitus, and lacunar infarction. After adjusting for confounding factors, DSWMH was correlated to advanced age and lacunar infarction. There was no correlation between serum Lp-PLA2 and DSWMH.Conclusions: Serum Lp-PLA2 was closely associated with the pathogenesis of PVWMH rather than DSWMH. There might be different pathological mechanisms between PVWMH and DSWMH.
Screen Fast, Screen Faster: A Pilot Study to Screen for Depressive Symptoms Using the Beck Depression Inventory Fast Screen in Parkinson's Disease With Mild Cognitive Impairment
Authors: Elben Saskia , Dimenshteyn Karina , Trenado Carlos , Folkerts Ann-Kristin , Ophey Anja , Sulzer Patricia , Becker Sara , Schmidt Nele , Tödt Inken , Witt Karsten , Liepelt-Scarfone Inga , Yilmaz Rezzak , Kalbe Elke , Wojtecki Lars 
Published: March 2021

Objective: Depressive symptoms have a high prevalence in patients with Parkinson's disease (PD) and are associated with cognitive dysfunction. Especially in PD with mild cognitive impairment (MCI), a time-efficient and valid instrument for the assessment of depression primarily focusing on psychological symptoms and disregarding confounding somatic symptoms is needed. We performed an examination of the psychometric properties of the Beck Depression Inventory II (BDI-II) and the Beck Depression Inventory Fast Screen (BDI-FS).Methods: The sample consisted of 64 patients [22 females and 42 males, mean age: 67.27 years (SD = 7.32)]. Depressive symptoms were measured in a cohort of PD patients with MCI. For the BDI-II and BDI-FS the psychometric concepts of internal consistency, convergent validity and diagnostic agreement were assessed.Results: Patients gave higher ratings on test items addressing somatic symptoms than those addressing non-somatic ones. The correlation between the absolute total scores of the BDI-II and the BDI-FS was significant (r = 0.91, p &lt; 0.001), which indicated convergent validity. The Cronbach's alpha values indicated adequate internal consistencies for both measures (BDI-II: 0.84; BDI-FS: 0.78). There was a higher than chance level agreement of diagnoses of the two questionnaires, measured by Cohen's kappa (0.58, p &lt; 0.001). The agreements between previous diagnosis of depression and the diagnoses of the BDI-II/BDI-FS were also significantly higher than chance level (BDI-II: 0.34, p = 0.007, BDI-FS: 0.39, p = 0.002). Additional AUC analysis across different cutoffs showed that performance of BDI-FS was better than BDI-II, supporting the observation of an equivalent or better performance of BDI-FS than BDI-II. Importantly, AUC analysis confirmed that a cutoff = 4 for BDI-FS was suitable in the considered sample of patients with PD-MCI.Discussion: In a cohort of PD-MCI, the BDI-FS demonstrates adequate psychometric properties in comparison to the BDI-II and can be used as a screening measure for assessing depression in cognitively impaired PD patients, focusing solely on psychological symptoms. Still, further research is needed to validate this instrument.
[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations
Authors: Colom Matthieu , Vidal Benjamin , Fieux Sylvain , Redoute Jérôme , Costes Nicolas , Lavenne Franck , Mérida Inés , Irace Zacharie , Iecker Thibaud , Bouillot Caroline , Billard Thierry , Newman-Tancredi Adrian , Zimmer Luc 
Published: March 2021

IntroductionSerotonin is involved in a variety of physiological functions and brain disorders. In this context, efforts have been made to investigate the in vivo fluctuations of this neurotransmitter using positron emission tomography (PET) imaging paradigms. Since serotonin is a full agonist, it binds preferentially to G-protein coupled receptors. In contrast, antagonist PET ligands additionally interact with uncoupled receptors. This could explain the lack of sensitivity to serotonin fluctuations of current 5-HT1A radiopharmaceuticals which are mainly antagonists and suggests that agonist radiotracers would be more appropriate to measure changes in neurotransmitter release. The present study evaluated the sensitivity to endogenous serotonin release of a recently developed, selective 5-HT1A receptor PET radiopharmaceutical, the agonist [18F]F13640 (a.k.a. befiradol or NLX-112).Materials and MethodsFour cats each underwent three PET scans with [18F]F13640, i.e., a control PET scan of 90 min, a PET scan preceded 30 min before by an intravenous injection 1 mg/kg of d-fenfluramine, a serotonin releaser (blocking challenge), and a PET scan comprising the intravenous injection of 1 mg/kg of d-fenfluramine 30 min after the radiotracer injection (displacement challenge). Data were analyzed with regions of interest and voxel-based approaches. A lp-ntPET model approach was implemented to determine the dynamic of serotonin release during the challenge study.ResultsD-fenfluramine pretreatment elicited a massive inhibition of [18F]F13640 labeling in regions known to express 5-HT1A receptors, e.g., raphe nuclei, hippocampus, thalamus, anterior cingulate cortex, caudate putamen, occipital, frontal and parietal cortices, and gray matter of cerebellum. Administration of d-fenfluramine during PET acquisition indicates changes in occupancy from 10% (thalamus) to 31% (gray matter of cerebellum) even though the dissociation rate of [18F]F13640 over the 90 min acquisition time was modest. The lp-ntPET simulation succeeded in differentiating the control and challenge conditions.ConclusionThe present findings demonstrate that labeling of 5-HT1A receptors with [18F]F13640 is sensitive to serotonin concentration fluctuations in vivo. Although the data underline the need to perform longer PET scan to ensure accurate measure of displacement, they support clinical development of [18F]F13640 as a tool to explore experimental paradigms involving physiological or pathological (neurological or neuropsychiatric pathologies) fluctuations of extracellular serotonin.
Survival Benefit of Crossover Administration of Regorafenib and Trifluridine/Tipiracil Hydrochloride for Patients With Metastatic Colorectal Cancer: Exploratory Analysis of a Japanese Society for Cancer of the Colon and Rectum Multicenter Observational Study (REGOTAS)
Authors: Chida Keigo , Kotani Daisuke , Moriwaki Toshikazu , Fukuoka Shota , Masuishi Toshiki , Takashima Atsuo , Kumekawa Yosuke , Kajiwara Takeshi , Yamazaki Kentaro , Komoda Masato , Makiyama Akitaka , Denda Tadamichi , Hatachi Yukimasa , Suto Takeshi , Sugimoto Naotoshi , Enomoto Masanobu , Ishikawa Toshiaki , Kashiwada Tomomi , Ando Koji , Yuki Satoshi , Okita Yoshihiro , Kusaba Hitoshi , Sakai Daisuke , Okamoto Koichi , Tamura Takao , Yamashita Kimihiro , Gosho Masahiko , Shimada Yasuhiro 
Published: March 2021

Background: The survival benefits of regorafenib (REG) and trifluridine/tipiracil hydrochloride (TFTD) have been demonstrated in chemorefractory patients with metastatic colorectal cancer (mCRC). However, the effects of crossover administration of REG and TFTD on patient survival remain unclear. The present study evaluated the association between exposure to REG and TFTD and overall survival (OS) in patients with mCRC using data from the REGOTAS study.Patients and Methods: We analyzed patients registered in the REGOTAS study, which retrospectively compared the efficacy and safety of use of REG or TFTD as later-line chemotherapy for chemorefractory mCRC patients. We compared the survival outcomes of cohort A (treated using both REG and TFTD) and cohort B (treated using either REG or TFTD).Results: A total of 550 patients (cohort A, n = 252; cohort B, n = 298) met the inclusion criteria. The median OS was significantly increased in cohort A compared with cohort B [9.6 months (95% confidence interval (CI), 8.9–10.9 months) vs. 5.2 months (95% CI, 4.4–6.0 months), P &lt; 0.001]. Multivariate analysis revealed that cohort A was independently associated with a significant increase in OS [A vs. B: Hazard ratios (HR), 0.58; 95% CI, 0.47–0.72; P &lt; 0.001]. Subgroup analysis adjusted using multivariate Cox model revealed a consistently better trend in most subgroups for cohort A compared with cohort B.Conclusions: Our study revealed prolonged survival in patients treated with REG and TFTD. Therefore, all active agents, including REG and TFTD, should be made available to mCRC patients.
Safety and Feasibility of Antibiotic De-escalation in Critically Ill Children With Sepsis – A Prospective Analytical Study From a Pediatric ICU
Authors: Battula Vasudha , Krupanandan Ravi Kumar , Nambi P. Senthur , Ramachandran Bala 
Published: March 2021

Introduction: De-escalation is the key to balance judicious antibiotic usage for life-threatening infections and reducing the emergence of antibiotic resistance caused by antibiotic overuse. Robust evidence is lacking regarding the safety of antibiotic de-escalation in culture negative sepsis.Materials and Methods: Children admitted to the PICU during the first 6 months of 2019 with suspected infection were included. Based on the clinical condition, cultures and septic markers, antibiotics were de-escalated or continued at 48–72 h. Outcome data like worsening of primary infection, acquisition of hospital acquired infection, level of ICU support and mortality were captured.Results: Among the 360 admissions, 247 (68.6%) children received antibiotics. After excluding 92 children, 155 children with 162 episodes of sepsis were included in the study. Thirty four episodes were not eligible for de-escalation. Among the eligible group of 128 episodes, antibiotics were de-escalated in 95 (74.2%) and continued in 33 (25.8%). The primary infection worsened in 5 (5.2%) children in the de-escalation group and in 1 (3%) in non de-escalation group [Hazard ratio: 2.12 (95%CI: 0.39–11.46)]. There were no significant differences in rates of hospital acquired infection, mortality or length of ICU stay amongst the groups. Blood cultures and assessment of clinical recovery played a major role in de-escalation of antibiotics and the clinician's hesitation to de-escalate in critically ill culture negative children was the main reason for not de-escalating among eligible children.Conclusion: Antibiotic de-escalation appears to be a safe strategy to apply in criticallly ill children, even in those with negative cultures.