bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between SARS-COV-2 RNA positive duration and the risk of recurrent positive
Authors: Zhao Hong , Zhang Chi , Chen Xian-Xiang , Zhu Qi , Huang Wen-Xiang , Zeng Yi-Lan , Liu Ying-Xia , Li Guo-Jun , Du Wei-Jun , Yao Jing , Li Jia-Wen , Peng Peng , Wang Gui-Qiang 
Published: March 2021

Abstract
Background
The management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challenging. However, there are fewer scientific dissertations about the risk of recurrent positive. The aim of this study was to explore the relationship between SARS-COV-2 RNA positive duration (SPD) and the risk of recurrent positive.

Methods
This case–control multi-center study enrolled participants from 8 Chinese hospital including 411 participants (recurrent positive 241). Using unadjusted and multivariate-adjusted logistic regression analyses, generalized additive model with a smooth curve fitting, we evaluated the associations between SPD and risk of recurrent positive. Besides, subgroup analyses were performed to explore the potential interactions.

Results
Among recurrent positive patients, there were 121 females (50.2%), median age was 50 years old [interquartile range (IQR): 38–63]. In non-adjusted model and adjusted model, SPD was associated with an increased risk of recurrent positive (fully-adjusted model: OR = 1.05, 95% CI: 1.02–1.08, P = 0.001); the curve fitting was not significant (P = 0.286). Comparing with SPD < 14 days, the risk of recurrent positive in SPD > 28 days was risen substantially (OR = 3.09, 95% CI: 1.44–6.63, P = 0.004). Interaction and stratified analyses showed greater effect estimates of SPD and risk of recurrent positive in the hypertension, low monocyte count and percentage patients (P for interaction = 0.008, 0.002, 0.036, respectively).

Conclusion
SPD was associated with a higher risk of recurrent positive and especially SPD > 28 day had a two-fold increase in the relative risk of re-positive as compared with SPD < 14 day. What’s more, the risk may be higher among those with hypertension and lower monocyte count or percentage.
Review: questionnaires as measures for low energy availability (LEA) and relative energy deficiency in sport (RED-S) in athletes
Authors: Sim Alexiaa , Burns Stephen F. 
Published: March 2021

AbstractBackgroundA sustained mismatch between energy intake and exercise energy expenditure (EEE) can lead to Low Energy Availability (LEA), health and performance impairments characteristic of Relative Energy Deficiency in Sport (RED-S). Questionnaires can conveniently identify symptoms and/or LEA/ RED-S risk factors. This study aimed to systematically identify, and critique questionnaires used or developed to measure LEA/ RED-S risk in athletic populations.MethodsA systematic search was conducted using PubMed database. Full text articles were included if: (i) the questionnaire(s) in the study identified LEA and/or RED-S risk; (ii) studies developed questionnaires to identify LEA and/or RED-S risk; (iii) participants belonged to athletic population(s); and (iv) in English.ResultsThirty-three articles met the inclusion criteria and were reviewed, 13 questionnaires were identified. Eight questionnaires had undergone validation procedures, and three questionnaires included questions related to EEE. The most widely used validated questionnaires were Low Energy Availability in Females Questionnaire (LEAF-Q) (48% articles) and Eating Disorder Examination Questionnaire (EDE-Q) (12% articles). The LEAF-Q determines LEA risk from symptoms but cannot be used in males as nearly half of the items (n = 12) relate to menstrual function. The EDE-Q serves as a surrogate marker of LEA risk in both sexes, as it measures a major risk factor of LEA, disordered eating. Better validation is needed for many questionnaires and more are needed to address LEA/RED-S risk in male athletes.ConclusionThese questionnaires may be effective in identifying intentional energy restriction but less valuable in identifying inadvertently failure to increase energy intake with increased EEE.
A peer interview qualitative study exploring support for carers of people with comorbid autism and eating disorders
Authors: Kinnaird Emma , Oakley Madeleine , Lawrence Vanessa , Shergill Sukhi , Tchanturia Kate 
Published: March 2021

Abstract
Background
Carers of people with eating disorders (EDs) are known to experience a lack of support, high levels of unmet needs and resulting distress. Specific support and interventions for carers may benefit both the carer, and their loved one with an ED. Individuals with co-occurring autism and EDs may present with additional needs and difficulties relating to their Autism Spectrum Condition (ASC) that impact their carers. However, there is a lack of research exploring whether carers of people with ASC and EDs have specific support needs, and what kinds of support may be most beneficial for this population.

Methods
This study used a qualitative interview design, utilising peer interviews. Eleven carers participated in interviews about their experiences as a carer, and their views on existing support systems and potential improvements. As the study took place during the initial UK coronavirus lockdown, the impact of the lockdown also emerged as a topic during the interviews. Interviews were transcribed and analysed using thematic analysis.

Results
Five themes were identified: challenges associated with co-occurring Autism and EDs, a lack of existing support for carers from healthcare services, the personal impact of caring for someone with both ASC and EDs, ideas for how carers can be best supported, and the impact of the coronavirus on carers.

Conclusions
Carers of loved ones with both ASC and EDs described the experience as having a significant personal impact on their lives, but also experienced a lack of support from healthcare services. There was a perception that caring for someone with both an ASC and EDs presents additional challenges compared to caring for someone with an ED only, and that this population therefore requires specialised support. Recommendations for possible support options, and for further research, are outlined.
The rediscovery of an Adoration of the Shepherds by Jacques Jordaens: a multidisciplinary approach combining dendroarchaeology and art history
Authors: Edvardsson Johannes , Seim Andrea , Davies Justin , Vander Auwera Joost 
Published: March 2021

Abstract
The implementation of multidisciplinary research approaches is an essential prerequisite to obtain comprehensive insights into the life and works of the old masters and their timeline in the production of the arts. In this study, traditional art history, cultural heritage, and natural science methods were combined to shed light on an Adoration of the Shepherds painting by Jacques Jordaens (1593–1678), which until now had been considered as a copy. From dendrochronological analysis of the wooden support, it was concluded that the planks in the panel painting were made from Baltic oak trees felled after 1608. An independent dating based on the panel maker’s mark, and the guild’s quality control marks suggests a production period of the panel between 1617 and 1627. Furthermore, the size of the panel corresponds to the dimension known as salvator, which was commonly used for religious paintings during the period 1615 to 1621. Finally, the interpretation of the stylistic elements of the painting suggests that it was made by Jordaens between 1616 and 1618. To conclude, from the synthesis of: (i) dendrochronological analysis, (ii) panel makers’ punch mark and Antwerp Guild brand marks, (iii) re-examination of secondary sources, and (iv) stylistic comparisons to other Jordaens paintings, we suggest that the examined Adoration of the Shepherds should be considered as an original by Jordaens and likely painted in the period 1617–1618. The study is a striking example of the effectiveness of a multidisciplinary approach to investigate panel paintings.
Develop an efficient inoculation technique for Fusarium solani isolate “TJP-2178-10” pathogeny assessment in Phalaenopsis orchids
Authors: Chen Shu-Yun , Wu Yan-Jeng , Hsieh Ting-Fang , Su Jiunn-Feng , Shen Wei-Chiang , Lai Yung-Hsiang , Lai Pen-Chih , Chen Wen-Huei , Chen Hong-Hwa 
Published: March 2021

Abstract
Background
Phalaenopsis is one of the important ornamental plants worldwide. It plays the most significant role in flower exportation in Taiwan. However, the yellow leaf disease caused by Fusarium spp. has reduced the orchid flower yield 10–50 % yearly. Varieties resistant to yellow leaf disease associated with Fusarium is urgently needed for orchid growers and breeders, and is the ultimate solution for the long-term goal. To achieve this, phenotyping is the first step and the most necessary information for further studies, such as resistance gene identification, quantitative trait loci identification, and genome-wide association study.

Results
The inoculation of Fusarium was performed in either abbreviated stem or detached leaf, and the pros and cons were compared. The former is the general method of phenotyping for estimating the tolerance to yellow leaf disease of Phalaenopsis, but it is time-consuming and spacy, and thus not suitable for the assessment of large numbers of samples. In contrast, the latter not only showed a similar trend of disease severity with time reduced to only one fourth of the former one but also less space needed.

Conclusions
This solution allows a better phenotyping approach for the fast detection of yellow leaf disease associated with Fusarium in a large number of Phalaenopsis samples.
Functional status of mechanically ventilated COVID-19 survivors at ICU and hospital discharge
Authors: Musheyev Benjamin , Borg Lara , Janowicz Rebeca , Matarlo Michael , Boyle Hayle , Singh Gurinder , Ende Victoria , Babatsikos Ioannis , Hou Wei , Duong Tim Q. 
Published: March 2021

Abstract
Background
A significant number of COVID-19 patients have been treated using invasive mechanical ventilation (IMV). The ability to evaluate functional status of COVID-19 survivors early on at ICU and hospital discharge may enable identification of patients who may need medical and rehabilitation interventions.

Methods
The modified “Mental Status”, ICU Mobility, and Barthel Index scores at ICU and hospital discharge were tabulated for 118 COVID-19 survivors treated with invasive mechanical ventilation (IMV). These functional scores were compared with pre-admission functional status, discharge durable medical equipment, discharge medical follow-up recommendation, duration on IMV, duration post-IMV, demographics, comorbidities, laboratory tests, and vital signs at ICU and hospital discharge.

Results
The majority of COVID-19 IMV patients were not functionally independent at hospital discharge (22% discharged with cane or rolling walker, 49% discharged with durable medical equipment, and 14% admitted to a rehabilitation facility), although 94% of these patients were functionally independent prior to COVID-19 illness. Half of the patients were discharged with supplemental oxygen equipment. The most prevalent medical follow-up recommendations were cardiology, vascular medicine, pulmonology, endocrinology, and neurology with many patients receiving multiple medical follow-up recommendations. Functional status improved from ICU discharge to hospital discharge (p < 0.001). Worse functional status at hospital discharge was associated with longer IMV duration, older age, male sex, higher number of comorbidities, and the presence of pre-existing comorbidities including hypertension, diabetes, chronic obstructive pulmonary disease, and immunosuppression (p < 0.05, ANOVA).

Conclusions
The majority of IMV COVID-19 survivors were not functionally independent at discharge and required significant follow-up medical care. The COVID-19 circumstance has placed constraints on access to in-hospital rehabilitation. These findings underscore the need for prospective studies to ascertain the short- and long-term sequela in COVID-19 survivors.
Isolating non-subduction-driven tectonic processes in Cascadia
Authors: McKenzie K. A. , Furlong K. P. 
Published: March 2021

AbstractSeveral tectonic processes combine to produce the crustal deformation observed across the Cascadia margin: (1) Cascadia subduction, (2) the northward propagation of the Mendocino Triple Junction (MTJ), (3) the translation of the Sierra Nevada–Great Valley (SNGV) block along the Eastern California Shear Zone–Walker Lane and, (3) extension in the northwestern Basin and Range, east of the Cascade Arc. The superposition of deformation associated with these processes produces the present-day GPS velocity field. North of ~ 45° N observed crustal displacements are consistent with inter-seismic subduction coupling. South of ~ 45° N, NNW-directed crustal shortening produced by the Mendocino crustal conveyor (MCC) and deformation associated with SNGV-block motion overprint the NE-directed Cascadia subduction coupling signal. Embedded in this overall pattern of crustal deformation is the rigid translation of the Klamath terrane, bounded on its north and west by localized zones of deformation. Since the MCC and SNGV processes migrate northward, their impact on the crustal deformation in southern Cascadia is a relatively recent phenomenon, since ~ 2 –3 Ma.
Self-efficacy and belonging: the impact of a university makerspace
Authors: Andrews Madison E. , Borrego Maura , Boklage Audrey 
Published: March 2021

AbstractBackgroundIn recent years, makerspaces have become increasingly common venues of STEM education and are rapidly being incorporated into undergraduate programs. These spaces give students and instructors access to advanced design technology and facilitate the incorporation of a wide variety of projects into the curriculum; however, their impacts on students are not yet fully understood. Using matched survey responses (i.e., repeated measures) from undergraduate students enrolled in engineering courses that assigned a makerspace-based project, we evaluate how the use of a university makerspace impacts students’ attitudes towards design, engineering, and technology. Further, we examine whether there are differences based on students’ year in program, gender, and race.ResultsPairedt-tests were used to analyze whether and how nine factors changed within individual students over one semester. Analyses revealed that students who visited the facility showed significant gains in measures of innovation orientation, design self-efficacy, innovation self-efficacy, technology self-efficacy, belonging to the makerspace, and belonging to the engineering community. Subsequently, repeated measures analyses of variance (RMANOVAs) on the students who visited the makerspace revealed significant main effects of students’ year in program, gender, and race, as well as interactional effects of both year in program and race with time.ConclusionsThese results affirm the value of incorporating makerspace-based projects into STEM curricula, especially during early coursework. However, our analyses revealed consistent gender gaps in measures of self-efficacy before and after using the makerspace. Similarly, gains in belonging to the makerspace were not equal across racial groups. We conclude that while makerspaces are fulfilling some of their promise for educating innovative problem solvers, more attention needs to be paid to avoid reproducing disparities in STEM education that are already experienced by female students and racial minorities.
Measuring supports from learning assistants that promote engagement in active learning: evaluating a novel social support instrument
Authors: Hernandez Dania , Jacomino Gema , Swamy Uma , Donis Krista , Eddy Sarah L. 
Published: March 2021

Abstract
Background
Active learning supports student performance, but can be challenging to implement in large courses. The Learning Assistant (LA) Program is a growing intervention to support students in large active learning classrooms. This program places advanced undergraduates who have training in pedagogical methods in active learning classrooms to interact with and support students during in-class activities. LAs increase student performance, but the mechanism behind this is still unclear. Social support is a promising framework to help elucidate the types and extent of assistance LAs provide to students and begin exploring the “how” behind LAs effectiveness. The aim of this study was to develop an instrument measuring undergraduate students’ perceptions of the social supports for active learning available to them in the classroom. This instrument was based on both the broader social support literature and the literature on what factors encourage students to engage deeply in active learning. To provide initial evidence of validity, the instrument was completed in six sections of General Chemistry I at one R1 university. Exploratory and confirmatory factor analyses were applied to determine the internal structure of the instrument. Then the instrument’s relationship to engagement in active learning was evaluated as another form of validity evidence.

Results
These analyses best supported a three-factor instrument that included five items representing supportive feedback provided during active learning (appraisal support), eight items representing emotional support during active learning, and six items representing the communications of norms and values related to active learning (informational support). All three factors were individually correlated with three measures of engagement. In regression analyses with all three factors measured together, only informational support predicted changes in two of the three measures of engagement.

Conclusions
This study supports the use of the Perception of Social Supports for Active Learning (PSSALI) instrument to understand students’ perceptions of the supports they are receiving to engage in active learning in chemistry courses. One implication of this work is that in order to increase engagement, learning assistants should clearly communicate the value of active learning and the classroom norm of active participation.
Tissue dose estimation after extravasation of 177Lu-DOTATATE
Authors: Tylski Perrine , Pina-Jomir Géraldine , Bournaud-Salinas Claire , Jalade Patrice 
Published: March 2021

Abstract
Background
Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234–1243, 2017). Clinical management of these extravasations requires the preliminary estimation of the dose distribution in the extravasation area. Data are scarce regarding the dose estimation in the literature. This work presents a methodology for estimating the dose distribution after an extravasation occurred in September 2017, in the arm of a patient during a 7.4-GBq infusion of Lutathera ® (AAA).

Methods
A local quantification procedure initially developed for renal dosimetry was used. A calibration factor was determined and verified by phantom study. Extravasation volume of interest and its variation in time were determined using 4 whole body (WB) planar acquisitions performed at 2 h (T2h), 5 h (T5h), 20 h (T20h), and 26 h (T26h) after the beginning of the infusion and three SPECT/CT thoracic acquisitions at T5h, T20h, and T26h. For better estimation of initial extravasation volume, 3 volumes were defined on SPECT images using a 3D activity threshold. Cumulated activities and associated absorbed doses (D1, D2, D3) were calculated in the 3 volumes using the MIRD formalism.

Results
Volumes estimated using 3D threshold were V1 = 1000 mL, V2 =400 mL, and V3 =180 mL. Cumulated activities were evaluated using a monoexponential fit on activities calculated on SPECT images. Estimated local absorbed doses in V1, V2, and V3 were D1 = 2.3 Gy, D2 = 4.1 Gy, and D3 = 6.8 Gy. Evolution in time of local activity in the extravasation area was consistent with an effective local half-life (Teff) of 2.3 h.

Conclusions
Rapid local dose estimation was permitted thanks to knowledge of the calibration factor determined previous to accidental extravasation. Lutathera® lymphatic drainage was quick in the arm (Teff = 2.3h). Estimated doses were in the lower range of deterministic effects and far under soft tissue necrosis threshold. Thus, no surgical rinse was proposed. The patient did not show any clinical consequence of the extravasation.
Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT
Authors: Morimoto Masatoshi , Kudomi Nobuyuki , Maeda Yukito , Kobata Takuya , Oishi Akihiro , Matsumoto Keisuke , Monden Toshihide , Iwasaki Takanobu , Mitamura Katsuya , Norikane Takashi , Yamamoto Yuka , Nishiyama Yoshihiro 
Published: March 2021

Abstract
Background
The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortening in brain tumor PET/CT using 11C-methionine on the quantitative values.

Method
This study was a retrospective analysis of 30 patients who underwent clinical 11C-methionine PET/CT examination. PET images were acquired in list mode for 10 min. PET images of acquisition duration from 1 to 10 min with 1-min step were reconstructed. We examined the effect on the quantitative values of acquisition duration. We placed a volume of interest to include the entire tumor and regions of interest in the shape of a large crescent in the contralateral hemisphere in 5 contiguous axial slices as normal tissue. Quantitative values examined were maximum, peak, and mean standardized uptake values (SUVmax, SUVpeak, SUVmean), metabolic tumor volume (MTV), and maximum tumor to normal tissue ratio (TNRmax), with each duration compared to that with 10 min.

Results
SUVmax, MTV, and TNRmax showed the highest values due to the effects of statistical noise when the acquisition time was 1 min. These values were stable when the acquisition duration was > 6 min. SUVpeak and SUVmean showed mostly consistent values regardless of duration.

Conclusions
SUVmax, MTV, and TNRmax are affected by acquisition time. If the acquisition duration was > 6 min, the fluctuation could be suppressed within 5% in these quantitative values. However, SUVpeak was suggested to be a robust index regardless of the acquisition duration.