bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive potential of tropical fruit flies in temperate regions under climate change
Authors: Gutierrez Andrew Paul , Ponti Luigi , Neteler Markus , Suckling David Maxwell , Cure José Ricardo 
Published: September 2021

AbstractTropical fruit flies are considered among the most economically important invasive species detected in temperate areas of the United States and the European Union. Detections often trigger quarantine and eradication programs that are conducted without a holistic understanding of the threat posed. Weather-driven physiologically-based demographic models are used to estimate the geographic range, relative abundance, and threat posed by four tropical tephritid fruit flies (Mediterranean fruit fly, melon fly, oriental fruit fly, and Mexican fruit fly) in North and Central America, and the European-Mediterranean region under extant and climate change weather (RCP8.5 and A1B scenarios). Most temperate areas under tropical fruit fly propagule pressure have not been suitable for establishment, but suitability is predicted to increase in some areas with climate change. To meet this ongoing challenge, investments are needed to collect sound biological data to develop mechanistic models to predict the geographic range and relative abundance of these and other invasive species, and to put eradication policies on a scientific basis.
In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes
Authors: Scalise Mariangela , Marino Fabiola , Salerno Luca , Mancuso Teresa , Cappetta Donato , Barone Antonella , Parrotta Elvira Immacolata , Torella Annalaura , Palumbo Domenico , Veltri Pierangelo , De Angelis Antonella , Berrino Liberato , Rossi Francesco , Weisz Alessandro , Rota Marcello , Urbanek Konrad , Nadal-Ginard Bernardo , Torella Daniele , Cianflone Eleonora 
Published: September 2021

AbstractmiRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to-what-extent these miRNA/mRNA networks are operative during cardiomyocyte differentiation of adult cardiac stem/progenitor cells (CSCs). Clonally-derived mouse CSCs differentiated into contracting cardiomyocytes in vitro (iCMs). Comparison of “CSCs vs. iCMs” mRNome and microRNome showed a balanced up-regulation of CM-related mRNAs together with a down-regulation of cell cycle and DNA replication mRNAs. The down-regulation of cell cycle genes and the up-regulation of the mature myofilament genes in iCMs reached intermediate levels between those of fetal and neonatal cardiomyocytes. Cardiomyo-miRs were up-regulated in iCMs. The specific networks of miRNA/mRNAs operative in iCMs closely resembled those of adult CMs (aCMs). miR-1 and miR-499 enhanced myogenic commitment toward terminal differentiation of iCMs. In conclusions, CSC specification/differentiation into contracting iCMs follows known cardiomyo-MiR-dependent developmental cardiomyocyte differentiation trajectories and iCMs transcriptome/miRNome resembles that of CMs.
Orientations and water dynamics of photoinduced secondary charge-separated states for magnetoreception by cryptochrome
Authors: Hamada Misato , Iwata Tatsuya , Fuki Masaaki , Kandori Hideki , Weber Stefan , Kobori Yasuhiro 
Published: September 2021

AbstractIn the biological magnetic compass, blue-light photoreceptor protein of cryptochrome is thought to conduct the sensing of the Earth’s magnetic field by photoinduced sequential long-range charge-separation (CS) through a cascade of tryptophan residues, WA(H), WB(H) and WC(H). Mechanism of generating the weak-field sensitive radical pair (RP) is poorly understood because geometries, electronic couplings and their modulations by molecular motion have not been investigated in the secondary CS states generated prior to the terminal RP states. In this study, water dynamics control of the electronic coupling is revealed to be a key concept for sensing the direction of weak magnetic field. Geometry and exchange coupling (singlet–triplet energy gap: 2J) of photoinduced secondary CS states composed of flavin adenine dinucleotide radical anion (FAD−•) and radical cation WB(H)+• in the cryptochrome DASH from Xenopus laevis were clarified by time-resolved electron paramagnetic resonance. We found a time-dependent energetic disorder in 2J and was interpreted by a trap CS state capturing one reorientated water molecule at 120 K. Enhanced electron-tunneling by water-libration was revealed for the terminal charge-separation event at elevated temperature. This highlights importance of optimizing the electronic coupling for regulation of the anisotropic RP yield on the possible magnetic compass senses.
Coupled social and land use dynamics affect dietary choice and agricultural land-use extent
Authors: Pal Saptarshi , Bauch Chris T. , Anand Madhur 
Published: September 2021

AbstractDietary patterns have long been a driver of global land use. Increasingly, they also respond to it, in part because of social processes that support adoption of eco-conscious diets. Here we develop a coupled social-and-land use mathematical model parameterised for 153 countries. We project global land use for future population, income, and agricultural yield using our coupled dynamical model. We find that coupled social-and-land feedbacks can alter the peak global land use for agriculture by up to 2 billion hectares, depending on the parameter regime. Across all yield scenarios, the model projects that social dynamics will cause an increase in eco-conscious dietary behaviour until the middle of the 21st century, after which it will decline in response to declining land use caused by a shrinking global population. The model also exhibits a regime of synergistic effects whereby simultaneous changes to multiple socio-economic parameters are required to change land use projections. This research demonstrates the value of including coupled social-and-land feedbacks in land use projections.
Large gaps and high accretion rates in photoevaporative transition disks with a dead zone
Authors: Gárate Matías , Delage Timmy N. , Stadler Jochen , Pinilla Paola , Birnstiel Til , Stammler Sebastian Markus , Picogna Giovanni , Ercolano Barbara , Franz Raphael , Lenz Christian 
Published: September 2021

Context. Observations of young stars hosting transition disks show that several of them have high accretion rates, despite their disks presenting extended cavities in their dust component. This represents a challenge for theoretical models, which struggle to reproduce both features simultaneously.
Aims. We aim to explore if a disk evolution model, including a dead zone and disk dispersal by X-ray photoevaporation, can explain the high accretion rates and large gaps (or cavities) measured in transition disks.
Methods. We implemented a dead zone turbulence profile and a photoevaporative mass-loss profile into numerical simulations of gas and dust. We performed a population synthesis study of the gas component and obtained synthetic images and SEDs of the dust component through radiative transfer calculations.
Results. This model results in long-lived inner disks and fast dispersing outer disks that can reproduce both the accretion rates and gap sizes observed in transition disks. For a dead zone of turbulence αdz = 10−4 and an extent rdz = 10 AU, our population synthesis study shows that 63% of our transition disks are still accreting with Ṁg ≥ 10−11 M⊙ yr−1 after opening a gap. Among those accreting transition disks, half display accretion rates higher than 5.0 × 10−10 M⊙ yr−1. The dust component in these disks is distributed in two regions: in a compact inner disk inside the dead zone, and in a ring at the outer edge of the photoevaporative gap, which can be located between 20 and 100 AU. Our radiative transfer calculations show that the disk displays an inner disk and an outer ring in the millimeter continuum, a feature that resembles some of the observed transition disks.
Conclusions. A disk model considering X-ray photoevaporative dispersal in combination with dead zones can explain several of the observed properties in transition disks, including the high accretion rates, the large gaps, and a long-lived inner disk at millimeter emission.
Evidence for stellar contamination in the transmission spectra of HAT-P-12b
Authors: Jiang C. , Chen G. , Pallé E. , Murgas F. , Parviainen H. , Yan F. , Ma Y. 
Published: September 2021

Context. Transmission spectroscopy characterizes the wavelength dependence of transit depth, revealing atmospheric absorption features in planetary terminator regions. In this context, different optical transmission spectra of HAT-P-12b reported in previous studies exhibited discrepant atmospheric features (e.g., Rayleigh scattering and alkali absorption).
Aims. We aim to understand the atmosphere of HAT-P-12b using two transit spectroscopic observations by the Gran Telescopio Canarias (GTC) and to search for evidence of stellar activity contaminating the transmission spectra, which might be the reason behind the discrepancies.
Methods. We used Gaussian processes to account for systematic noise in the transit light curves and used nested sampling for Bayesian inferences. We performed joint atmospheric retrievals using the two transmission spectra obtained by GTC OSIRIS, as well as previously published results, coupled with stellar contamination corrections for different observations.
Results. The retrieved atmospheric model exhibits no alkali absorption signatures, but shows tentative molecular absorption features including H2O, CH4, and NH3. The joint retrieval of the combined additional public data analysis retrieves similar results, but with a higher metallicity.
Conclusions. Based on Bayesian model comparison, the discrepancies of the transmission spectra of HAT-P-12b can be explained by the effect of different levels of unocculted stellar spots and faculae. In addition, we did not find strong evidence for a cloudy or hazy atmosphere from the joint analysis, which is inconsistent with prior studies based on the observations of the Hubble Space Telescope.
OMEP-EOR: A MeV proton flux specification model for electric orbit raising missions
Authors: Brunet Antoine , Sicard Angélica , Papadimitriou Constantinos , Lazaro Didier , Caron Pablo 
Published: September 2021

Electric Orbit Raising (EOR) for telecommunication satellites significantly reduced on-board fuel mass at the price of extended transfer durations. These relatively long transfers, which usually span a few months, cross large spans of the radiation belts, resulting in significant exposure of the spacecraft to space radiations. Since they are not very populated, the radiation environment of intermediate regions of the radiation belts is less constrained than on popular orbits such as low Earth orbit or geostationary orbit in standard environment models. In particular, there is a need for more specific models for the MeV energy range proton fluxes, responsible for solar arrays degradations, and hence critical for EOR missions. ONERA has developed a specification model of proton fluxes dedicated for EOR missions as part of the ESA ARTES program. This model can estimate the average proton fluxes between 60 keV and 20 MeV on arbitrary trajectories on the typical duration of EOR transfers. A global statistical model of the radiation belts was extracted from the Van Allen Probes RBSPICE data. For regions with no or low sampling, simulation results from the Salammbô radiation belt model were used. Special care was taken to model the temporal dynamics of the belts on the considered mission durations. A Gaussian Process model was developed, allowing to compute the distribution of the average fluxes on arbitrary mission durations analytically. Satellites trajectories can be flown in the resulting global distribution, yielding the proton flux spectrum distribution as seen by the spacecraft. We show the results of the model on a typical EOR trajectory. The obtained fluxes are compared to the standard AP8 model, the AP9 model and validated using the THEMIS satellites data. We illustrate the expected effect on solar cell degradation, where our model shows an increase of up to 20% degradation prediction compared to AP8.
Bilder sind Daten: Eine Perspektive der Brustbildgebung auf ein zeitgenössisches Paradigma
Authors: Dietzel Matthias , Clauser Paola , Kapetas Panagiotis , Schulz-Wendtland Rüdiger , Baltzer Pascal Andreas Thomas 
Published: September 2021

Hintergrund Radiologische Untersuchungen nicht nur als bloße Bilder, sondern als Datenquelle zu betrachten, ist zum modernen Paradigma der diagnostischen Bildgebung geworden. Dieser Perspektivwechsel hat sich besonders in der Brustbildgebung durchgesetzt, ermöglicht er doch, aus der Informatik abgeleitete Verfahren anzuwenden, innovative klinische Anwendungen zu realisieren und bereits etablierte Methoden zu verfeinern. In diesem Zusammenhang sind die Begriffe „bildgebender Biomarker“, „Radiomics“ und „künstliche Intelligenz“ von zentraler Bedeutung. Diese Methoden versprechen nichtinvasive, kostengünstige (z. B. im Vergleich zu Multigen-Arrays), workflow-freundliche (automatisiert, nur eine Untersuchung, sofortige Ergebnisse) und klinisch relevante Informationen.
Methoden und Ergebnisse Dieser Artikel wurde als narratives Review zu dem besagten Paradigma im Bereich der Brustbildgebung konzipiert. Der Schwerpunkt liegt auf den Schlüsselkonzepten und wichtigen Schlagworten. Für alle Bereiche der Brustbildgebung werden beispielhafte Studien diskutiert.
Schlussfolgerung Die Interpretation von radiologischen Untersuchungen als Datenquelle verspricht eine Optimierung der Behandlung von Brustkrebspatientinnen im Zeitalter der Präzisionsmedizin, weil damit die Diagnose verfeinert und eine individualisierte Behandlung erreicht werden könnte.
Kernaussagen:
Verteilung des 21-Gen-Rezidiv-Scores bei Patientinnen mit primärem Mammakarzinom in Deutschland
Authors: Walter Vincent P. , Taran Florin-Andrei , Wallwiener Markus , Bauer Armin , Grischke Eva-Maria , Walter Christina Barbara , Hahn Markus , Brucker Sara Y. , Hartkopf Andreas Daniel 
Published: September 2021

Zusammenfassung
Einleitung Multigen-Assays werden zunehmend als Entscheidungshilfe für eine Chemotherapie beim Mammakarzinom verwendet. Wir stellen hier den 21-Gen-Recurrence-Score (RS) von Patientinnen mit Brustkrebs vor, die routinemäßig in Deutschland untersucht wurden.
Patientinnen und Methoden 4695 Patientinnen mit hormonrezeptorpositivem und HER2-negativem Brustkrebs im Frühstadium (pT1–3, pN0–1, M0) wurden einer retrospektiven Analyse unterzogen. Bei diesen Patientinnen wurde in Deutschland zwischen November 2015 und Juli 2018 der Genexpressionstest Oncotype DX zur Ermittlung des Recurrence-Scores durchgeführt. Die Klassifikation der RS-Gruppen erfolgte gemäß der TAILORx Studie (RS: 0–10; 11–25; 26–100).
Ergebnisse Von diesen Patientinnen wurden 21 % in die niedrige RS-Gruppe, 63 % in die mittlere RS-Gruppe, und 15 % in die hohe RS-Gruppe eingeteilt. 1772 (81 %) von 2175 Patientinnen im Alter von über 50 Jahren und ohne Lymphknotenbefall wurden entweder in die niedrige oder die mittlere RS-Gruppe eingeteilt. Der Prozentsatz an Patientinnen mit einem niedrigen oder mittleren RS betrug 90 % bei Patientinnen ohne Lymphknotenbefall (1284 von 1432 Patientinnen), 79 % bei Patientinnen mit einem hohen (≥ 20 %) Ki-67-Wert (1829 von 2310 Patientinnen), 86 % bzw. 70 % bei Patientinnen mit G2- bzw. G3-Tumoren (3244 von 3762 Patientinnen bzw. 368 von 522 Patientinnen), 88 % bei Patientinnen mit einem Tumordurchmesser von > 5 cm (140 von 159 Patientinnen) und 82 % bei Patientinnen ohne Lymphknotenbefall, aber mit einem hohen klinischen Risiko (1110 von 1352).
Schlussfolgerung Die Verteilung des 21-Gens RS bei deutschen Patientinnen, die in der klinischen Routinepraxis getestet wurden, deutet darauf hin, dass gemäß den Ergebnissen der TAILORx-Studie die Chemotherapie bei den meisten dieser Patientinnen keinen Nutzen hat.
Gewalt gegen Kreißsaalpersonal – Ergebnisse einer
Online-Befragung und von Leitfadeninterviews an Berliner
Geburtskliniken
Authors: Böhle Saskia , David Matthias , Breckenkamp Jürgen , Henrich Wolfgang , Seidel Vera 
Published: September 2021

Zusammenfassung
Einleitung Gewalt gegenüber medizinischem Personal ist ein
bekanntes Problem in der Notfallversorgung. Es gibt wenig empirische Daten zu
körperlicher und verbaler Gewalt gegen Kreißsaal-Personal in
Deutschland.
Methodik Es handelt sich um eine Studie mit quantitativer und qualitativer
Datenerhebung. Für die quantitative Erhebung wurden zwischen dem
15.11.2019 und 15.02.2020 Hebammen, Ärztinnen und Ärzte, die in
Kreißsälen Berliner Geburtskliniken tätig sind, mittels
Fragebogen zu Gewalterleben innerhalb der letzten 6 Monate befragt. Im Rahmen
der qualitativen Erhebung wurde die Thematik mittels Leitfadeninterviews
vertiefend beleuchtet.
Ergebnisse Von 173 Teilnehmern waren nach eigenen Angaben 148
(86%) verbaler Gewalt und 82 (47%) körperlicher Gewalt
ausgesetzt. Hebammen und junges Personal scheinen häufiger von Gewalt
betroffen zu sein. Von den Teilnehmenden fühlten sich ca. 70%
nicht ausreichend auf Gewaltsituationen vorbereitet. In den 36 Interviews wurden
insbesondere Kommunikationsprobleme, zu hohe Erwartungshaltungen der Schwangeren
und ihrer Begleitung, Sprachbarrieren und kulturelle Missverständnisse
als Gewalt begünstigend genannt.
Schlussfolgerung Gewalt gegen Personal ist ein relevantes Problem in
Kreißsälen in Berlin. Schulungsangebote zum Umgang mit Gewalt
und professionelle Aufarbeitung von Gewalterlebnissen wurden von den Befragten
gewünscht. Verbesserte Aufklärung über Schwangerschaft
und Geburt, institutionalisierte Sprachmittlung und mehr Personal
könnten helfen, die Häufigkeit von Gewalt zu senken.
Assessment of Oral Anticancer Medication Adherence: A Survey from a Tertiary Cancer Center
Authors: Ramachandiran Balaji , Dubashi Biswajit , Kayal Smita , Menon Vikas , Yuvaraj K. , Deepika C. , Francis Deepa , Debbarma Deeksha , Nair Devika S. 
Published: September 2021

Abstract
Background Adherence to oral anticancer medication is important in cancer chemotherapy, with the advent of many oral anticancer regimens to ensure adequate cytologic response. Literature on adherence to oral anticancer therapy in India is very less.
Materials and Methods This is a cross sectional analytical study consisting of all fit patients > 18 years of age taking oral anticancer therapy, with or without intravenous (IV) chemotherapy. Adherence was determined using Morisky–Green–Levine (MGL) scale, and factors affecting adherence details about cancer and treatment were obtained. All fit patients were recruited. Information was obtained using Tamil questionnaire and pro forma.
Observation Of 152 patients, only 111 patients were found to be adherent to treatment. The mean age of the study population was 49.03 ± 13.48 years. Only 12.5% of patients were aware of the diagnosis, treatment, and outcome. The study population consisted mainly of patients with chronic myeloid leukemia, colorectal carcinoma, breast carcinoma, and stomach carcinoma, which amounted for 78.3% of the study population. Bivariate analysis concluded that duration of treatment, adverse drug reaction (ADR), duration of oral anticancer drug intake in a month, coadministration with IV anticancer drugs, and frequency of drug intake (anticancer drug) were significant factors affecting drug adherence. Multivariate analysis of the above variables was insignificant, but ADR tended toward significance.
Conclusion Drug adherence plays a major role in treatment outcome in cancer patients. ADR was independently associated with decreased drug adherence. Key interventions which should include counseling and behavioral modifications will reduce nonadherence.
Liderazgo femenino en medicina y su evolución en el tiempo: 50 años de análisis bibliométrico
Authors: Mendoza Catalina Solano , Gomez Andrea Patricia Bolaños , Tobar Veronica , Carvajal Luisana Castillo , Vega Johanna , Jaimes Luz Marina Bernal 
Published: September 2021

ResumenObjetivo Realizar un análisis bibliométrico sobre el liderazgo femenino en medicina para conocer el panorama actual y dirigir futuras investigaciones.Métodos Se realizó un análisis bibliométrico descriptivo retrospectivo de la literatura disponible en MEDLINE en relación con el liderazgo de mujeres médicas de 1973 al 2019.Se utilizó Pubmed y FABUMED, y la siguiente estrategia: ("Leadership"[Mesh]) AND "Physicians, Women"[Mesh] (1973:2019[dp]). Se incluyeron artículos originales, de revista, ensayos, informes científicos y reseñas, para analizar toda la literatura indexada relacionada.Para la obtención del factor de impacto (FI), se utilizó el Journal Citation Reports (7)2017/2018 de las revistas encontradas para estimar la calidad de cada una de ellas.Resultados Un total de 310 referencias fueron encontradas en 139 revistas publicadas, el 71,2% fueron artículos originales, el resto revisiones. Hubo un incremento en las publicaciones de 1996 al 2019 en un 11,9%. Las revistas con mayor porcentaje de publicaciones fueron: Academic Medicine y J Womens Health (Larchmt), con 7,7% y 7,1%. Los países con mayores publicaciones fueron Estados Unidos, con 66 (56%) y Reino Unido con 10 (8,6%). América latina tiene cuatro publicaciones y Colombia no cuenta con ninguna publicación indexada.Conclusión El liderazgo femenino en medicina y las publicaciones sobre el tema han aumentado en las últimas décadas en países industrializados. Por su parte, Latinoamérica debe aumentar sus esfuerzos en publicar en revistas con alto factor de impacto para trabajar por la equidad de género.
The Effect of Glyphosate on Human Sperm: In Vitro Approximation
Authors: Morales Velásquez Mateo , Velásquez Rivera Valentina , Cardona Maya Walter D. 
Published: September 2021

Abstract
Introduction Glyphosate is an herbicide used to eradicate illicit crops; however, its use is controversial due to different health problems associated with it. The present study aims to evaluate the effects of glyphosate on human sperm in vitro.
Methods Twenty-two semen samples from healthy normozoospermic men were included; 11 semen samples were incubated with Panzer (INVESA S.A., Antiquia, Colombia) and 11 with Roundup (Monsanto Company, MO, USA). The changes in motility and viability were observed. Functional seminal parameters were evaluated as well.
Results The samples exposed to glyphosate showed less motility and viability; a decrease in the potential of the mitochondrial membrane was observed, and an increase in the lipoperoxidation of the membrane was evidenced.
Conclusion Based on the present results, we concluded that glyphosate has cytotoxic potential for exposed people and may affect their fertility.