bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-distribution of Light at Night (LAN) and COVID-19 Incidence in the United States
Authors: Meng Yidan , Zhu Vincent , Zhu Yong 
Published: March 2021

Abstract
Background: Light at night (LAN) as a circadian disruption factor may affect the human immune system and consequently increase an individual’s susceptibility or the severity of infectious diseases, such as COVID-19. COVID-19 infections spread differently in each state in the United States (US). The current analysis aimed to test whether there is an association between LAN and COVID-19 cases in 4 selected US states: Connecticut, New York, California, and Texas.Methods: We analyzed clustering patterns of COVID-19 cases in ArcMap and performed a multiple linear regression model using data of LAN and COVID-19 incidence with adjustment for confounding variables including population density, percent below poverty, and racial factors. Results: Hotspots of LAN and COVID-19 cases are located in large cities or metro-centers for all 4 states. LAN intensity is associated with cases/1k for overall and lockdown durations in New York and Connecticut (P <0.001), but not in Texas and California. The overall case rates is significantly associated with LAN in New York (P <0.001) and Connecticut (P <0.001). Conclusions: We observed a significant positive correlation between LAN intensity and COVID-19 cases-rate/1k, suggesting that circadian disruption of ambient light may increase the COVID-19 infection rate possibly by affecting an individual's immune functions. Furthermore, differences in the demographic structure and lockdown policies in different states play an important role in COVID-19 infections.
Effect of Buttress Form on Transverse Seismic Resistance of High Masonry Walls
Authors: Gürel M. Arif , İzol Rabia , Mollamahmutoğlu Çağrı , Pekgökgöz R. Kadir , Yüksel F. Şebnem Kuloğlu , Özeren Meryem 
Published: March 2021

Abstract
In historical masonry structures having vault, dome and high walls, for safety against gravity, wind and earthquake loads, buttresses are crucial elements. This study aims to investigate the effect of buttress form on the transverse seismic resistance of high masonry walls. For this purpose, a real historical masonry structure covered by a barrel vault, and has a simple and regular plan and elevation shape was considered. From a slice of this structure, a calculation model and a basic model were created. For the masonry, macro-modelling approach was used. Nonlinear static analysis method was adopted, and finite element modeling and calculations were carried out using the Abaqus program. Firstly, on the calculation model the effect of buttress depth on transverse seismic resistance was investigated, and it was seen that the resistance is almost linearly related to the buttress depth. Then, two groups of analyses were performed on the models obtained by mounting different buttress forms to the basic model. In the first group, the volumes of the buttresses were kept equal, and in the second group their base depths and thicknesses were taken equally. At the end of these analyses, by comparing the base shear forces obtained for the models, the effectiveness of buttress form on the transverse seismic resistance has been determined and evaluated. The results revealed that the model with curvilinear concave buttresses in the first group analyses and the model with semi-cylindrical buttresses in the second group analyses have the highest seismic resistance.
A Common Human Problem Has a Name: Misokinesia
Authors: Jaswal Sumeet M. , Blesser Andreas D. , Handy Todd C. 
Published: March 2021

Abstract
Misokinesia –– or the ‘hatred of movements’ –– is a psychological phenomenon that is defined as a strong negative affective or emotional response to the sight of someone else’s small and repetitive movements, such as seeing someone mindlessly fidgeting with a hand or foot. Among those who regularly experience misokinesia, there is a growing recognition of the challenges that it presents, as evidenced by blossoming on-line support groups. Yet surprisingly, scientific research on the topic is lacking. This article is novel in systematically examining whether misokinesia exists in the non-clinical population and if there are observable individual variability in the intensity or extent of reported misokinesia sensitivity in the general population. Across three studies that included 4100 participants, we confirmed the existence of misokinesia as a phenomenon in a non-clinical population, with approximately one-third of our participants self-reporting some degree of misokinesia sensitivity to the repetitive, fidgeting behaviors of others as encountered in their daily lives. Moreover, variability in the range of misokinesia sensitivities showed that the negative social-affective impacts that one experiences may grow with age. This study shows that a large population of the public may be suffering from something that has received little formal recognition.
Membrane Lipids and Maximum Lifespan in Clownfish
Authors: PAGÁN PEDRO FRANCISCO ALMAIDA , Lucas-Sanchez Alejandro , Martinez-Nicolas Antonio , Terzibasi Eva , Lama Maria Angeles Rol de , Cellerino Alessandro , Mendiola Pilar , Costa Jorge de 
Published: March 2021

Abstract
The longevity-homeoviscous adaptation (LHA) theory of aging states that lipid composition of cell membranes is linked to metabolic rate and lifespan, which has been widely shown in mammals and birds but not sufficiently in fish. In this study, two species of the genus Amphiprion (A. percula and A. clarkii, with estimated maximum lifespan potentials [MLSP] of 30 and 9-16 years, respectively) and the damselfish Chromis viridis (estimated MLSP of 1-2 years) were chosen to test the LHA theory of aging in a potential model of exceptional longevity. Brain, livers and samples of skeletal muscle were collected for lipid analyses and integral part in the computation of membrane peroxidation indexes (PIn) from phospholipid (PL) fractions and PL fatty acid composition. When only the two anemonefish were compared, results pointed to the existence of a negative correlation between membrane PIn value and maximum life expectancy, well in line with the predictions from the LHA theory of aging. Nevertheless, contradictory data were obtained when the two clownfish were compared to the shorter-lived C. viridis. This results along with those obtained in previous studies on fish denote that the magnitude (and sometimes the direction) of the differences observed in membrane lipid composition and peroxidation index with MLSP cannot explain alone the diversity in longevity found among fishes.
Development, implementation and real-life use assessment of HIBOOT: a smartphone application for safety, self-assessment and medication adherence for patients with inflammatory arthritis. A user-centred step-by-step approach.
Authors: BEAUVAIS Catherine , Pham Thao , Montagu Guillaume , Gleizes Sophie , Madrisotti Francesco , Lafourcade Alexandre , Vidal Céline , Dervin Guillaume , Baudard Pauline , Desouches Sandra , Tubach Florence , Calvez Julian Le , Quatrebarbes Marie de , Lafarge Delphine , Grange Laurent , Alliot-Launois Françoise , Jeantet Henri , Antignac Marie , Tropé Sonia , Besset Ludovic , Sellam Jérémie 
Published: March 2021

Abstract
Background

Mobile health applications (apps) are increasing in interest for enhancing patient self-management in rheumatology. However, few have been developed with the involvement of patients and health professionals and actually used by patients.

Objective

To develop and implement a mobile app for safety, self-assessment and medication adherence for patients with inflammatory arthritis treated with disease modifying anti-rheumatic drugs (DMARDs) and assess its real-life use.

Methods

A mixed qualitative-quantitative study including 42 and 344 patients, respectively, identified patients’ treatment practices and their use of health apps in general and their needs in terms of content and potential use. A multidisciplinary team including 7 rheumatologists, 3 patient association representatives and 4 members of a digital company developed the first version of the app with face-to-face meetings and patient feedback during the process. After the launch of the app, users’ feedback assessment included 7 patients and 3 rheumatologists. The number of app installations, current users, users’ requests and functionalities used were collected.

Results

Preliminary studies indicated numerous safety issues and needs for counselling, leading to the 6 functionalities of the app HIBOOT (OWL in English): a safety checklist before treatment administration, aid in daily life situations related to self-management and safety, treatment reminders, global well-being self-assessment, periodic counselling messages, and a diary to note comments and appointments. The app is free, with no personal data collection. The presentation is a friendly companion that interacts with the user. The content was based on the French recommendations for DMARD management, drug leaflets and public national health websites. HIBOOT was installed 20,500 times from 2017 to 2020, with 4300 regular current users and still increasing usage curves. The checklist, diary and queries on daily life situations were the most used functionalities. Overall, 18,000 requests were identified for information on safety or other patient matters over a 8-month period in 2020. Scores were 4.4/5 stars at Android and iOS stores.

Conclusion

HIBOOT is a free app for patients with inflammatory arthritis that was developed with a preliminary qualitative–quantitative study including patients during the process and has scientifically validated content. The number of current users is substantial. Future evaluation of the HIBOOT benefit is needed.
Porcine pancreatic ductal epithelial cells transformed with KRAS G12D and SV40T are tumorigenic
Authors: Bailey Katie L. , Cartwright Sara B. , Patel Neesha S. , Remmers Neeley , Lazenby Audrey J. , Hollingsworth Michael A. , Carlson Mark A. 
Published: March 2021

Abstract
We describe our initial studies in the development of an orthotopic, genetically-defined, large animal model of pancreatic cancer. Primary pancreatic epithelial cells were isolated from pancreatic duct of domestic pigs. A transformed cell line was generated from these primary cells with oncogenic KRAS and SV40T. The transformed cell lines outperformed the primary and SV40T immortalized cells in terms of proliferation, population doubling time, soft agar growth, transwell migration and invasion. The transformed cell line grew tumors when injected subcutaneously in nude mice, forming glandular structures and staining for epithelial markers. Future work will include implantation studies of these tumorigenic porcine pancreatic cell lines into the pancreas of allogeneic and autologous pigs. The resultant large animal model of pancreatic cancer could be utilized for preclinical research on diagnostic, interventional, and therapeutic technologies.
Detection of PD-L1 expression in temozolomide-resistant glioblastoma by using PD-L1 antibodies conjugated with lipid-coated superparamagnetic iron oxide
Authors: Lee Gilbert , Lin Wan-Li , Kuo Duen-Pang , Li Yi-Tien , Chang Yu-Wei , Chen Yung-Chieh , Huang Shiu-Wen , Hsu Justin Bo-Kai , Chen Cheng-Yu 
Published: March 2021

Abstract
Background: Targeted superparamagnetic iron oxide (SPIO) nanoparticles are a promising tool for molecular magnetic resonance imaging (MRI) diagnosis. Lipid-coated SPIO nanoparticles have a nonfouling property that can reduce nonspecific binding to off-target cells and prevent agglomeration, making them suitable contrast agents for molecular MRI diagnosis. PD-L1 is a poor prognostic factor for patients with glioblastoma. Most recurrent glioblastomas are temozolomide-resistant. Diagnostic probes targeting PD-L1 could help early diagnosis and be used to predict the responses of targeted PD-L1 immunotherapy in patients with primary and recurrent glioblastoma. In this study, we conjugated lipid-coated SPIO nanoparticles with PDL1 antibodies to identify PDL1 expression in glioblastoma or temozolomide-resistant glioblastoma by using MRI.Results: The synthesized PD-L1 antibody–conjugated SPIO (PDL1-SPIO) nanoparticles were characterized using dynamic light scattering, zeta potential assays, transmission electron microscopy images, in vitro cell affinity assay, and in vivo MRI analysis. These data demonstrated that PDL1-SPIO has a specific binding capacity to PD-L1 of the mouse glioblastoma cell line (GL261). The presence and quantity of PDL1-SPIO in temozolomide-resistant glioblastoma cells and tumor tissue were confirmed through Prussian blue staining and in vivo T2* map MRI, respectively.Conclusions: These findings revealed that PDL1-SPIO can specifically target temozolomide-resistant glioblastoma with PD-L1 expression and can be quantified with MRI analysis, thereby making it suitable for the diagnosis of PD-L1 expression in temozolomide-resistant glioblastoma in vivo.
Ion Imprinted Polymers Prepared with a Novel Cd(II) Methacrylate Monomer Complex with 1-Vinylimidazole for Selective Removal of Cd(II) Ions
Authors: Yolcu Zuhal , Çıtlakoğlu Meryem 
Published: March 2021

Abstract
A novel [Cd(maa)2(vim)2H2O]·H2O monomer complex was synthesized using methacrylic acid (maaH) and 1-vinylimidazole (vim) that are suitable ligands for polymerization with cadmium central atom. Cd(II)-IIP was prepared by precipitation polymerization technique using monomer complex, EGDMA, and AIBN as functional monomer, crosslinker, and initiator, respectively. The structure of the monomer complex was elucidated by single-crystal X-ray diffraction method. Infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA) methods were used for characterization both of the monomer complex and Cd(II)-IIP. Scanning electron microscopy / energy-dispersive X-ray spectroscopy (SEM/EDX) methods were used for observation surface morphology and content of the polymer surfaces. The adsorption performance and selectivity properties of Cd(II)-IIP were also investigated. The maximum adsorption capacity of Cd(II)-IIP was 43.0 mg/g with 250 mg/L initial Cd(II) concentration at pH:6.0, and the selectivity was higher for Cd2+ ions than that of Pb2+, Ni2+, and Zn2+ as competitor ions. The Langmuir and Freundlich isotherm models were applied comparatively to experimental results. Cd(II) ion content of the solutions determined by inductively coupled plasma mass spectrometry (ICP-MS).
Refractive errors and visual impairment among children and adolescents in southernmost China
Authors: Peng Li , Gao Ling , Zheng Yunyan , Dai Yanan , Xie Qing 
Published: March 2021

Abstract
Background: Refractive errors and visual impairment in southernmost China have not been reported previously. We aim to investigate and determine the age-specific prevalence of myopia, hyperopia, astigmatism, and visual impairment based on a large population cross-sectional study in Hainan area of southernmost tropical province in China. Methods: A population-based sample of 31,524 children aged 6-15 years from Hainan was assessed. Non-cycloplegic autorefraction and visual acuity (VA) analyses were performed on all participants and a subgroup of participants undergoing cycloplegia. Results: Of all participators, 22.986% presented uncorrected VA (UCVA) decreased worse than 0.3logMAR, 17.206% presented UCVA decreased worse than 0.5logMAR and 46.95% presented abnormal UCVA [worse than 0.1logMAR (≥6, <8 years old) and worse than 0logMAR(≥8years and older)] at least in one eye. The overall prevalence of myopia [spherical equivalent (SE) ≤−0.50 D] and high myopia (SE≤−6.00 D) were 45.97%, 0.96% respectively. Hyperopia [SE ≥+1.00 D (≥7 years old) and SE ≥+2.00 D (≥6, <7 years old)] and significant hyperopia (SE≥+3.00 D) were 4.21% and 0.62%, respectively. Astigmatism [cylinder≥1.00 D (≥7 years old) and ≥+1.75 D (≥6, <7 years old)] was found in 31.87%. Conclusions: Myopia was the most common refractive error in southernmost province in China (Hainan). Its prevalence increased with age, while hyperopia prevalence showed a decreasing trend. However, myopia, especially high myopia prevalence was much lower than in other urban regions across China, as residents of Hainan may benefit from more ultraviolet B (UVB) radiation during daylight exposure.
Low Urinary Iodine is a Protective Factor of Central Lymph Node Metastasis in Papillary Thyroid Cancer: A Cross-sectional Study
Authors: Zeng Ziyang , Li Kang , Wang Xianze , Ouyang Siwen , Zhang Zimu , Liu Zhen , Sun Juan , Ye Xin , Kang Weiming , Yu Jianchun 
Published: March 2021

Abstract
Background: An abrupt increase of thyroid cancer has been witnessed paralleling the supplemented iodine intake in formerly iodine-deficient countries. And increased iodine intake has been linked to the rising incidence rate of papillary thyroid cancer (PTC). However, the correlation between iodine and clinicopathological features of PTC has not been well-characterized. This study aimed to investigate the associations between iodine intake and the clinicopathological features of PTC patients.Methods: 359 PTC patients who have received surgical treatment in Peking Union Medical College Hospital from May 2015 to November 2020 were retrospectively reviewed. The associations between urinary iodine (UI), urinary iodine/creatinine ratio (UI/U-Cr) and the clinicopathological features of PTC were analyzed. Univariate and multivariate analysis were performed to investigate the relationship between UI level and central lymph node metastasis (CLNM).Results: There were no significant differences of UI in different groups according to the variables studied, except that patients with CLNM had higher UI level than CLNM(-) patients. No associations were found between UI/U-Cr and clinicopathological features except variant subtypes (classic/follicular). After dividing patients into high-iodine group and low-iodine group, more patients were found to have CLNM in high-iodine group (p=0.017). In addition, younger age, larger tumor size and classic variant positively correlated with CLNM (p<0.05). Univariate analysis showed that insufficient iodine intake (≤ 99 μg/L) were associated with decreased CLNM risk in PTC. And after defining insufficient iodine intake as ≤ 109 μg/L and above requirements as ≥ 190 μg/L, multivariate analysis showed that lower iodine was associated with CLNM in total population of PTC (OR: 0.53, 95 % CI: 0.31 - 0.91) and in PTC < 1cm (papillary thyroid microcarcinoma, PTMC) (OR: 0.43, 95 % CI: 0.21 - 0.87).Conclusions: Low iodine was a protective factor for CLNM in papillary thyroid cancer, particularly in those < 1 cm. These results indicated that iodine may not only be an initiator of tumorigenesis, but also a promoter of the development of PTC.
Membranes with a dual structure constituted of titania, zirconia, and both as thin-film selective layers coating the polyacrylonitrile platform
Authors: Worou Chabi N. , Chen Zhonglin 
Published: March 2021

Abstract
Three novel thin-film composite (TFC) nanofiltration membranes are prepared using an ultrafiltration membrane (UFM) of organic polymer resin polyacrylonitrile followed by a mineralization process. The UFM was hydrolyzed (H-UFM) and then transferred in dopamine (DA) and tris buffer (TRIS) solutions. DA–TRIS coating is further favorable for the growth of nanoparticles (NPs), titania (TiO2), and zirconia (ZrO2) on membrane piece surface. A scanning electron microscope (SEM) was combined with an energy-dispersive spectrometer (EDS) in order to provide important insights into the arrangement and potential functions of NPs, due to their unambiguous chemical signal, for possible characterization and modification of materials at the atomic scale. Depending on whether the top layer is made of TiO2, ZrO2, or both, the membranes are called, respectively, TFC-NFTitan, TFC-NFZircon, and TFC-NFTitanZircon. The three membranes under the optimized preparation conditions (30 °C, 12 h of hydrolysis time, and operating pressure of 0.6 MPa) exhibited high rejection and permeation performance. TFC-NFTitanZircon showed the highest rejection (89–95%) for divalent cations with the salt rejection sequence of , while the permeate flux is not less than . All three membranes demonstrated long-term durability under 120-h testing.
Manggaraian expressions of environmental preservation: a study on ecolinguistics
Authors: Rambut Kanisius 
Published: March 2021

This paper explores the manggaraian expressions that used to explain the inisiative of people in Manggarai to preserve the environtment. This is a kind of code in which located the local wisdom to manage the surroundings as well as possible so that they will not be disappear. It promotes some problems such as meanings and functions of the expressions in term of preservation the environtment. Then it is designed to describe the meanings and functions of the expressions which become the indicators of environtmental development. These problems can be analyzed by theoretical conccep of ecolinguistics. It is viewed that language is the symbol verbal of comunication, used to describe the problems of environtments. In addition, Sapir said that vocabulary of languages in the world reflects the environtment of its speaker. The two statements indicate what language employs to draw the environtmental issues. It is sum up that language has very important roles to manage the environtment. Data collections includethe informations or qualitative statements that given by the informen, gathered from the field. These informations have been got through the interview and observation. The interview is a way to get the informations.