bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aquaculture in the structure of the agro-industrial complex of the Russian Federation: the current state of legal regulation
Authors: Semenova Irina  Vladimirovna 
Published: December 2024

The author describe the features of the legal regulation of aquaculture (fish farming). For the Russian Federation, fish farming is mainly at the stage of formation. The author analyzes the basic concepts used in the field under consideration and draws a parallel with similar terms used in the field of fishing. The author considers the configuration of the current legal regulation of aquaculture, as well as the prospects for its development. Special attention is paid to modern legislative gaps and topical issues that need to be addressed by the legislator, and the main directions for improving legislation in this area are outlined. In addition, the main environmental risks of aquaculture in case of non-compliance with legal requirements are identified. The methodological basis of the work is: general scientific dialectical, as well as private scientific methods of cognition - formal legal and comparative legal methods. It is noted that currently aquaculture in the Russian Federation is at the stage of evaluating and comprehending previously adopted legislative acts and measures of state support. The author formulated the main issues in the field of legal regulation of aquaculture, which require special attention for the development of this area of the fisheries complex. So, in particular, they include certain aspects of regulating the turnover of fish farms, measures taken to provide Russian fisheries with high-quality feed and planting material, the need to take new measures in the field of agricultural insurance for aquaculture, and others. The paper identifies the main problems hindering the stable and effective development of domestic aquaculture, as well as provides proposals and innovative technologies that contribute to their resolution.
Identification of the whole genome of alternative splicing and RNA-binding proteins involved in nintedanib-induced apoptosis in gastric cancer cells
Authors: Dong Xiaohua , Liu Zhilong , Yu Miao , Yang Xiaojun , Cai Hui 
Published: December 2024

Background
It has been demonstrated that nintedanib can inhibit the proliferation of gastric cancer cells, but the specific mechanism of action is unclear.

Objective
Investigating the changes of key factors involved in gene transcription and post-transcriptional regulation during the process of treating gastric cancer with nintedanib.

Methods
In this study, we performed transcriptome sequencing on gastric cancer cell groups treated with nintedanib and control groups. The SUVA (Splice sites Usage Variation Analysis) software was used to identify differential alternative splicing (AS) events between the nintedanib-treated group and the control group. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to assess the functional differences and pathways associated with these events. Finally, a co-expression regulatory network of differentially expressed RNA-binding proteins (RBPs) and differentially spliced genes was established. Results: A total of 915 differential AS events were identified between the two groups, and these differential genes were closely related to the apoptosis pathway. Further analysis revealed that differential RBPs (TAGLN2, TAGLN, SRSF6, PKM, SRSF2, NOC2L, IPO4, C1QBP, DHX9) may affect the anti-proliferative effect of nintedanib on gastric cancer cells by regulating downstream genes involved in cell proliferation and angiogenesis (NR4A1, BBC3, IFI27) through alternative splicing.

Conclusion
This study systematically identified important changes in alternative splicing and RNA-binding proteins during the process of nintedanib-induced apoptosis in gastric cancer cells. It innovatively revealed the mechanisms of action of nintedanib in gastric cancer cells and expanded the selection of new targets for gastric cancer treatment.
Malignant solid tumor-related spontaneous intracerebral hemorrhage: a propensity score matching study
Authors: Liang Shuolin , Liu Liuyu , Qin Bin , Chen Shengri , Liang Zhijian 
Published: December 2024

Background
Spontaneous intracerebral hemorrhage (sICH) is a severe event with high mortality. Recently, evidence has emerged suggesting that malignant solid tumors may increase the risk of sICH through unique cancer-related factors. However, the specific risk factors and clinical characteristics of sICH in patients with malignant solid tumor remain poorly understood.

Objective
This study aimed to investigate the clinical characteristics of and identify the risk factors associated with sICH in individuals with malignant solid tumors.

Methods
This retrospective study was carried out in patients with active malignant solid tumors and sICH at the First Affiliated Hospital of Guangxi Medical University between January 2010 and December 2020. Patients were separated into control and malignant solid tumor-related spontaneous intracerebral hemorrhage (MST-sICH) groups. The control group consisted of patients presenting with malignant solid tumors alone who were matched to the MST-sICH group using a 1:1 propensity score matching (PSM) approach. Patient clinical data, laboratory findings, and imaging results were collected. Univariate analysis was carried out to determine the risk factors associated with MST-sICH. In addition, a receiver operator characteristic analysis was performed to identify potential predictors for poor prognosis.

Results
Decreased hemoglobin (HGB) levels, together with increased lymphocyte counts (LYCs), and an increased neutrophil-to-lymphocyte ratio (NLR) were found in the MST-sICH group compared to the control group. The results of the multivariate logistic regression analysis indicated a HGB levels (OR: 0.959, 95% CI [0.928–0.992]), an increased in LYCs (OR: 0.095, 95% CI [0.023–0.392]). Furthermore, there was an increased in NLR levels (OR: 2.137, 95% CI [1.427–3.200]). In the receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) with HGB, LYCs, and NLR as joint predictors was 0.955 (95% CI [0.901–1.000]), with a sensitivity of 100%, a specificity of 82.6%, and a Youden Index of 0.826.

Conclusion
Decreased HGB levels, elevated LYCs, and a higher NLR were identified as independent risk factors for sICH in patients with active solid malignancies. These markers could assist clinicians in stratifying high-risk patients, facilitating closer monitoring and informing targeted preventive strategies to mitigate the incidence of sICH in this at-risk population.
Implications of the SNHG10/miR-665/RASSF5/NF-κB pathway in dihydromyricetin-mediated ischemic stroke protection
Authors: Zeng Qi , Xiao Yan , Zeng Xueliang , Xiao Hai 
Published: December 2024

Ischemic stroke (IS) remains a leading cause of disability and mortality worldwide, and inflammation and oxidative stress play significant roles in its pathogenesis. This study investigates the effects of dihydromyricetin (DHM) on IS using RT-qPCR and western blot with SH-SY5Y cells, focusing on its effects on the small nucleolar RNA host gene 10 (SNHG10)/microRNA (miR)-665/Ras association domain family member 5 (RASSF5) axis and nuclear factor-kappa B (NF-κB) signaling. In addition, the effects of the SNHG10/miR-665/RASSF5 axis on SH-SY5Y cell activity, apoptosis, oxidative stress, and inflammatory markers were analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry, and enzyme-linked immunosorbent assays. Our results showed that, in response to oxygen-glucose deprivation/reperfusion (OGD/R), DHM treatment improved cell viability, reduced apoptosis, and attenuated neuroinflammation and oxidative stress in a dose-dependent manner (p < 0.05). Interestingly, lncRNA SNHG10 was overexpressed during OGD/R and suppressed by DHM. Through bioinformatics analysis and experimental validation, we identified miR-665 as a direct target of SNHG10 and RASSF5 as a direct target of miR-665. The protective effect of DHM against OGD/R injury was partially reversed by SNHG10 overexpression and further enhanced by co-transfection with the miR-665 mimic and si-RASSF5 (p < 0.05). This study identifies a novel mechanism of DHM against IS, which may act via modulation of the SNHG10/miR-665/RASSF5 axis and inactivation of NF-κB signaling, and offers a promising therapeutic target for IS.
Die rechtsmissbräuchliche Sonderprüfung und ihre Folgen
Authors: Lieder Jan 
Published: December 2024

Zusammenfassung
Die Sonderprüfung nach §§ 142 ff. AktG eröffnet den Aktionären die Möglichkeit, das Vorstandshandeln einer Kontrolle zu unterziehen, wenn eine Unternehmensüberwachung durch den Aufsichtsrat an Grenzen stößt. Wie bei anderen Gesellschafterrechten besteht allerdings auch bei der Sonderprüfung die Gefahr des Missbrauchs und der treuwidrigen Ausübung. Der Beitrag spürt den Erscheinungsformen der rechtsmissbräuchlichen Sonderprüfung nach und misst ihre Rechtsfolgen aus. Dabei stehen die Zwangseinziehung der Aktien des Initiators sowie Schadensersatzansprüche der AG gegen diesen Aktionär im Mittelpunkt.
Bifacial Cu2ZnSn(S,Se)4 Thin Film Solar Cell Based on Molecular Ink and Rapid Thermal Processing
Authors: Khan Saqib Nawaz , Ge Sijie , Gu Ening , Karunakaran Santhosh Kumar , Yang Wentao , Hong Ruijiang , Mai Yaohua , Lin Xianzhong , Yang Guowei 
Published: August 2021

AbstractThe use of transparent conducting oxides (TCO) as a back contact for Cu2ZnSn(S,Se)4 (CZTSSe) thin film solar cell enables light absorption from both front and rear sides and allows for the fabrication of semi‐transparent photovoltaic devices. However, the CZTSSe solar cell based on TCO substrate suffers from high parasitic losses owing to the long post‐annealing time at elevated temperature required for high‐quality absorber. This work aims to overcome this issue by carefully tailoring the annealing conditions to obtain high‐performance solar cell. Rapid thermal processing is used to instantaneously generate high Se vapor pressure at target temperature and shorten the annealing time. The crystalline quality, morphology, and particularly the photovoltaic performance of the resulting CZTSSe thin film are systematically investigated. It is found that the increase of annealing temperature and time improves the crystalline quality but unfortunately deteriorates the device performance owing to increasing parasitic losses. Increasing the amount of Se allows to get highly crystalline absorber within 7 min of annealing, yielding a total area 5.56% efficient CZTSSe solar cell with front illumination resulting from reducing parasitic losses. This work provides a simple approach to preserve the back contact without using a complex interfacial layer.
Victor Almon McKusick: In the footsteps of Mendel and Osler
Authors: Francomano Clair A. 
Published: August 2021

AbstractVictor Almon McKusick (VAM) is widely recognized as the father of the field of medical genetics. He established one of the first medical genetics clinics in the United States at Johns Hopkins in 1957 and developed a robust training program with the tripartite mission of education, research, and clinical care. Thousands of clinicians and scientists were educated over the years through the Short Course in Medical and Molecular Genetics, which VAM founded with Dr. Thomas Roderick in 1960. His Online Mendelian Inheritance in Man (OMIM), a catalog of human genes and genetic disorders, serves as the authoritative reference for geneticists around the globe. Throughout his career he was an advocate for mapping the human genome. He collaborated with Dr. Frank Ruddle in founding the International Human Gene Mapping Workshops in the early 70's and was an avid proponent of the Human Genome Project. He was the founding President of the Human Genome Organization and a founding editor of the journal Genomics. His prodigious contributions to the field of medical genetics were recognized by multiple honors, culminating with the Japan Prize in 2008.
Effect of carbon black on properties of acrylonitrile‐chloroprenerubber
Authors: De Sarkar Mousumi , Sunada Takashi , Tomizawa Seiya , Kondo Atsunori 
Published: August 2021

AbstractImpacts of different grades of carbon black (CB) on the properties of the newly developed copolymer of chloroprene and acrylonitrile are discussed here. Seven commercial grades of CB, from three generic categories based on their manufacturing: furnace black, thermal black, and acetylene black, encompassing a large range of surface areas, structures, and surface activities, are considered in this comprehensive study. The impacts exerted by the different CB on viscosity, cure characteristics, mechanical properties, and some functional features, such as resistance to abrasion, heat build‐up, heat aging resistance, and solvent‐resistance of the poly(acrylonitrile‐chloroprene) rubber (NCR) vulcanizates are investigated. Mooney viscosity, cross‐link density, and most of the physical properties are strongly influenced by the filler morphologies such as surface area and the structure of CB.
Selective arterial embolization of renal angiomyolipomas: A 10‐year experience
Authors: Nozadze Guram , Larsen Signe Benzon , Heerwagen Søren , Juhl Jensen Ruben , Lönn Lars , Røder Martin Andreas 
Published: August 2021

AbstractObjectivesTo study safety and efficacy of selective endovascular trans‐arterial embolization (TAE) of renal angiomyolipoma (AML) in a 10‐year period at a regional tertiary referral center in Denmark.Patients and methodsAll 56 patients who underwent TAE of renal AML at Departments of Urology and Radiology, Copenhagen University Hospital – Rigshospitalet, Denmark, from 2009 to 2020 were included. Seven without preoperative and postoperative imaging were excluded, leaving 49 patients for analysis. From national electronic medical records, we retrieved patient characteristics, surgical data, and follow‐up data. Tumor size at the time of embolization and during follow‐up was compared using Student's paired t test. Estimated glomerular filtration rate (eGFR) pre‐ and post‐embolization were compared using Wilcoxon rank sum test.ResultsWe included 49 patients of whom 4 had two tumors treated in the same TAE procedure. Median age was 50 years (interquartile range [IQR]: [29–67 years]), and the median follow‐up time was 4.6 years [IQR: 3.0–6.7 years]. Post‐embolization syndrome (PES) was experienced in 27 patients, and non‐PES in 5 patients. Median length of hospital stay was 0 days [IQR, 0–1]. Postoperative Everolimus immunosuppressive treatment was offered to seven patients. Median tumor size was 6.0 cm [IQR: 4.6–7.9 cm] and was significantly reduced to 3.7 cm [IQR: 2.5–5.2 cm] after treatment (p < 0.001). Kidney function was not affected by TAE. Three deaths, not related to AML, were noted during follow‐up.ConclusionEmbolization of AML was in this cohort effective to significantly reduce tumor size without serious adverse events and loss of renal function. TAE is a safe and efficacious treatment and the preferred minimally invasive treatment option of AML.
Facing the mirror: Partnering to support struggling college writers
Authors: Parisi Hope , Fogelman Faith 
Published: August 2021

AbstractFostering a sense of belonging for community college students is a shared responsibility among all institutional areas, including academics, student services, and student life. This article presents a collaborative tutorial initiated and sustained by academics and support services that addressed the needs of students cycling through writing remediation. Institutional collaborative efforts like this one speak to the institutional responsibility for creating culturally responsive environments as part of student support.
Does industry experience increase the teaching of “soft” skills in community college classrooms?
Authors: Hora Matthew T. , Lee Changhee 
Published: August 2021

AbstractIndustry experience is widely viewed as an important requirement for community college teachers, as it may provide instructors with insights on how to teach important workplace “soft” skills. In this chapter, we discuss a study exploring this issue and why industry experience alone is insufficient preparation for effective skills‐focused teaching.
Outcomes of 10,312 patients treated with everolimus‐eluting bioresorbable scaffolds during daily clinical practice – results from the European Absorb Consortium
Authors: Wiebe Jens , Hofmann Felix J. , West Nick , Baumbach Andreas , Carrie Didier , Bermudez Eduardo Pinar , Cayla Guillaume , Hernandez Felipe Hernandez , de la Torre Hernandez Jose M. , Koning René , Loi Bruno , Moscarella Elisabetta , Tarantini Giuseppe , Zaman Azfar , Lober Christiane , Riemer Thomas , Achenbach Stephan , Hamm Christian W. , Nef Holger M. ,   the European ABSORB Consortium (EAC) investigators
Published: August 2021

AbstractObjectivesTo asses mid‐term clinical outcomes of bioresorbable vascular scaffolds (BVS) for the treatment of coronary artery disease in a large‐scale all‐comers population.BackgroundSeveral clinical settings are underrepresented in randomized studies investigating BVS against drug‐eluting stents. Whether their results can be translated into the heterogeny patient population seen during daily routine requires further investigation.MethodsThe European ABSORB Consortium comprises the following European registries: GABI‐R, ABSORB UK Registry, ABSORB France, BVS RAI Registry, and REPARA BVS Registry, which all prospectively collected patient‐level data regarding outcomes following unrestricted BVS implantation. The primary endpoint of target lesion failure (TLF) includes cardiac death, target‐vessel myocardial infarction (TVMI) and target‐lesion revascularisation (TLR) at 12 months. The incidence of scaffold thrombosis (ST) according to ARC criteria was also assessed. Multivariable analysis was used to adjust for differences in patient and lesion characteristics.ResultsA total of 10,312 patients (mean age 58.4 ± 11.4 y) underwent BVS implantation during routine practice. The 12‐month follow‐up was complete in 95.5% of patients. At 12 months, the primary endpoint of TLF occurred in 3.6%; its components cardiac death, TVMI and TLR were documented in 1.2%, 1.8%, and 2.6%, respectively. The definite/probable ST rate was 1.7%. Absence of predilatation, discontinuation of DAPT and scaffold diameter below 3 mm were independent predictors of ST.ConclusionsThe EAC demonstrates reasonable real‐world clinical outcome data after BVS implantation. However, the rate of scaffold thrombosis remains high.
Genotypical glioblastoma of the frontal lobe mimicking ganglioglioma: A case report and review of the literature
Authors: Kraus Theo F. J. , Pöppe Johannes , Machegger Lukas , Zellinger Barbara , Dovjak Eva , Schlicker Hans U. , Schwartz Christoph , Ladisich Barbara , Spendel Mathias , Al‐Schameri Abdul R. , Winkler Peter A. , Sotlar Karl 
Published: August 2021

AbstractThis case of severe phenotype‐genotype mismatch brain tumor morphologically mimicking benign ganglioglioma emphasizes the urgent need for advanced molecular profiling in brain tumor diagnosis in the era of sophisticated molecular profiling.
Diagnosis and management of oral cavity lipoblastoma and lipoblastomatosis in an 8‐month‐old boy
Authors: Matous Allison L. , Baker Michael L. , Khan Rihan , Pastel David A. , Chen Eunice Y. 
Published: August 2021

AbstractLipoblastoma/lipoblastomatosis presents some unique diagnostic and therapeutic challenges when encountered in the oral cavity. In these rare cases, diagnostic confirmation with molecular testing and a conservative surgical resection can contribute to successful management.
Surgical removal of an exceedingly rare papillary fibroelastoma of the aortic wall causing unstable angina
Authors: Masiello Paolo , Catalano Angelo , Mastrogiovanni Generoso , Eusebio Geppina , De Roberto Anna Maria , Chivasso Pierpaolo , Ciancia Giuseppe , Iesu Ivana , Triggiani Donato , Iesu Severino 
Published: August 2021

AbstractDifficult diagnosis is due to rarity of the case. TT or TE echocardiography is sufficient to make a correct diagnosis. The risk of embolism or coronary ostia occlusion should guide the decision for surgery.
When COVID‐19 delays the management of an urgent heart condition: A rare case of a spontaneous dissection of two coronary arteries
Authors: Endamena Gislain Beyina , Temgoua Mazou Ngou , Chanseaume Sylvain , Hilic Enver , Camus Lise , Chanseaume Alexandra , Mischie Alexandru , Kane Karamoko , Diallo Nouhoun , Assi Sami , Eschalier Romain 
Published: August 2021

AbstractSome severe life‐threatening conditions could be misdiagnosed during the current COVID‐19 pandemic.
Wieacker‐Wolff syndrome, a distinctive phenotype of arthrogryposis multiplex congenita caused by a “de novo”ZC4H2gene partial deletion
Authors: Deneufbourg Charlotte , Duquenne Armelle , Biard Jean‐Marc , Sznajer Yves 
Published: August 2021

AbstractUnusual fetal arthrogryposis on ultrasound should draw attention to look for additional lower limb anomalies. Precise genetic counseling may be obtained from deletion on Xq11.2 as forZC4H2 gene sequencing diagnostic for Wieacker‐Wolff syndrome.
Hypertension as a manifestation of COVID‐19 pneumonia
Authors: Bekbossynova Makhabbat , Ainur Tauekelova 
Published: August 2021

AbstractSeveral factors such as hypertension, bile duct disease, and age can affect the duration of COVID, which can lead to long COVID. Any course of coronavirus infection could have a diverse nature of clinical forms and should have a personalized approach.
First case of coloboma, lens neovascularization, traumatic cataract, and retinal detachment in a young Asian female
Authors: Gurnani Bharat , Kaur Kirandeep , Sekaran Subhashini 
Published: August 2021

AbstractLens neovascularization is a very rare entity to be encountered in the clinical practice. It is possibly a result of chronic ocular inflammation due to injury and subsequent uveitis. Early diagnosis and meticulous management can salvage visual acuity in such cases.
Substituent Effects in Six(Anilido)‐Five(Thiazole) Membered Ring Boron Difluoride Dyes
Authors: Tseng Sheng‐Ming , Chao Chi‐Min , Chang Kai‐Hsin , Wen Chi‐Sheng , Chou Tai‐Che , Tsai Tsung‐Lun , Wu Ting‐Wen , Haung Xiao‐Ci , Liu Jun‐Qi , Hung Cheng‐Hsien , Liu Kuan‐Miao , Chou Pi‐Tai 
Published: August 2021

AbstractA series of new six (anilido)‐five (thiazole) membered ring boron difluoride dyes, namely BFs, have been synthesized from the corresponding para‐ and meta‐substituted 2‐(2’‐methylaminophenyl) benzothiazoles through complexation with boron trifluoride. Depending on the substituent effect, the derivatives can switch the emission properties from fluorescence with 100 % emission yield to slim fluorescence but >90 % triplet state population and peak wavelength tuning from 490 nm to 610 nm. Compared with non‐complexed precursors, the rigid, highly planar structure and significantly red‐shifted absorption and emission for BFs indicate that the boron center facilitates the formation of a bridge leading to increased rigidity, and is also involved in π‐conjugation, increasing the transition dipole and suppressing the non‐radiative internal conversion. Together with optical ∼100 % transparent window around 325–375 nm, BFs may find unique applications, among which the fluorescence up‐conversion via triplet‐triplet annihilation is demonstrated.