bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canada’s changing innovation landscape
Authors: Alam Md. Razib , Koo Bonwoo , Cozzarin Brian Paul 
Published: September 2021

AbstractOur objective is to study Canada’s patenting activity over time in aggregate terms by destination country, by assignee and destination country, and by diversification by country of destination. We collect bibliographic patent data from the Canadian Intellectual Property Office and the United States Patent and Trademark Office. We identify 19,957 matched Canada–US patents, 34,032 Canada-only patents, and 43,656 US-only patents from 1980 to 2014. Telecommunications dominates in terms of International Patent Classification technologies for US-only and Canada–US patents. At the firm level, the greatest number of matched Canada–US patents were granted in the field of telecommunications, at the university level in pharmaceuticals, at the government level in control and instrumentation technology, and at the individual level in civil engineering. We use entropy to quantify technological diversification and find that diversification indices decline over time for Canada and the USA; however, all US indices decline at a faster rate.
Antiseptics leave the Clinic—The Introduction of (Puerperal) Prophylaxis in Austrian Midwifery Education (1870s–1880s)
Authors: Hilber Marina 
Published: September 2021

Summary
By introducing compulsory antiseptic measures in 1881, the Austrian Empire became a trendsetter in European midwifery legislation. Starting with the focus on puerperal infection in the 1870s, this article investigates the process from the first proposal of antiseptic regimes within a clinical setting to the dissemination of antiseptic knowledge among the midwifery profession. Competition between the leading medical men throughout the Austrian territories played a major role and influenced the way in which antiseptic measures were propagated. The article identifies the antiseptic collectives active at the leading universities of Prague and Vienna. As practical instruction during midwifery education was not regarded as sufficient, the late 1870s and 1880s saw the emergence of several instruction textbooks. Changing birth attendance routines and the innovative materials that entered midwifery practice are explored and discussed, based on these manuals, alongside evidence of midwives’ reactions as published in the Austrian Midwifery Newspaper.
The Plain Meaning Rule: A Quibble about Nomenclature and a Lot More
Authors: Simamba Bilika H 
Published: September 2021

Abstract
In the Cayman Islands, a British Overseas Territory, the proper understanding of the plain meaning rule (or literal rule) of statutory interpretation remains unclear. In its most basic iteration, the rule states that, where a statute is clear and unambiguous, the words must be given their natural and ordinary signification; there is no room for interpretation. That notwithstanding, to this day, even the meaning of the rule, as opposed to its application, still sometimes sparks debate in the Commonwealth. In 2015, a judge of the Grand Court in Cayman held that once a provision in a statute is clear and unambiguous, a court does not need to read the provision in its broader context. In a subsequent case, in 2018, a court of coordinate jurisdiction disagreed. It ruled that, even where a provision appears to be clear and unambiguous, a court must still read the statute in its fuller context in order to decipher the legal meaning in that particular context. This article discusses the plain meaning rule with a view to elucidating its proper understanding while questioning the appropriateness of its continuing nomenclature especially in light of developments in recent decades.
Slow Violence and theGas Peeditin Neoliberal India
Authors: Deb Nikhil 
Published: September 2021

AbstractThis article analyzes the ways in which slow violence and neoliberalism intertwine in the production of social and environmental destruction, evident in the lingering devastation from the 1984 Union Carbide catastrophe in Bhopal, India. Children are born with congenital abnormalities; women are plagued with reproductive health problems; and dangerous chemicals left in the abandoned factory continue to contaminate soil and groundwater. Yet Bhopal is remembered almost exclusively for the spectacle of its immediate aftermath. Drawing on 60 interviews with Bhopal victims and activists, field observations, archives, and official and independent reports, this paper examines how the neoliberal turn in Indian governance plays a role in the creation of slow violence. The paper advances our understanding of socioenvironmental destruction by tying slow violence to a temporal change in countries' governance in the Global South. The paper underscores the significance of considering political economic dynamics in the perpetration of slow violence. It also emphasizes how the neoliberal turn, now anchored in right-wing Hindutva politics in India, further constrains the possibilities for counter-measures that would address slow violence. The paper offers significant implications for analyzing the political economy of socioenvironmental and health disparities in the wake of corporate malfeasance.
Data sharing policies: share well and you shall be rewarded
Authors: Peccoud Jean 
Published: September 2021

Abstract
Sharing research data is an integral part of the scientific publishing process. By sharing data, authors enable their readers to use their results in a way that the textual description of the results does not allow by itself. In order to achieve this objective, data should be shared in a way that makes it as easy as possible for readers to import them in computer software where they can be viewed, manipulated and analyzed. Many authors and reviewers seem to misunderstand the purpose of the data sharing policies developed by journals. Rather than being an administrative burden that authors should comply with to get published, the objective of these policies is to help authors maximize the impact of their work by allowing other members of the scientific community to build upon it. Authors and reviewers need to understand the purpose of data sharing policies to assist editors and publishers in their efforts to ensure that every article published complies with them.
Smith and Philpott v Athol Administration Limited and ors, the Milewood Purpose Trust (2021), CHP2020/93
Authors: Rimmer John 
Published: September 2021

Abstract
A body of case law has now developed in relation to the well-known jurisdiction of common law courts to intervene in voluntary dispositions where they are made on the basis of a serious mistake. But what about the situation where some consideration has been given for the disposition? Does the existence of significant, or any, consideration deny the equitable remedy?
Impaired Spatial Inhibition Processes for Interhemispheric Anti-saccades following Dorsal Posterior Parietal Lesions
Authors: Ouerfelli-Ethier Julie , Salemme Romeo , Fournet Romain , Urquizar Christian , Pisella Laure , Khan Aarlenne Z 
Published: September 2021

Abstract
Anti-saccades are eye movements that require inhibition to stop the automatic saccade to the visual target and to perform instead a saccade in the opposite direction. The inhibitory processes underlying anti-saccades have been primarily associated with frontal cortex areas for their role in executive control. Impaired performance in anti-saccades has also been associated with the parietal cortex, but its role in inhibitory processes remains unclear. Here, we tested the assumption that the dorsal parietal cortex contributes to spatial inhibition processes of contralateral visual target. We measured anti-saccade performance in 2 unilateral optic ataxia patients and 15 age-matched controls. Participants performed 90 degree (across and within visual fields) and 180 degree inversion anti-saccades, as well as pro-saccades. The main result was that our patients took longer to inhibit visually guided saccades when the visual target was presented in the ataxic hemifield and the task required a saccade across hemifields. This was observed through anti-saccades latencies and error rates. These deficits show the crucial role of the dorsal posterior parietal cortex in spatial inhibition of contralateral visual target representations to plan an accurate anti-saccade toward the ipsilesional side.
Differences in branch hydraulic architecture related to the aridity of growing sites and seed sources of coastal Douglas-fir saplings
Authors: Lachenbruch Barbara , St. Clair J Bradley , Harrington Constance A 
Published: September 2021

AbstractTo better understand hydraulic adaptations of coastal Douglas-fir (Pseudotsuga menziesii var. menziesii (Mirb.) Franco) to local climate, we examined genetic (G) and environmental (E) responses of branch hydraulic architecture of 7-year-old saplings from dry and wet climates of origin grown at a relatively dry and a relatively wet common garden site in western Oregon. We sampled 2 years of branch growth from three dry-source and three wet-source families grown at both sites (72 branches, total). Overall, only 4 of the 11 traits had significant genetic (G) effects, whereas 9 traits had significant environmental (E) effects (P &lt; 0.05). Both dry and wet sources had higher leaf-specific conductance (kl) at the dry than the wet site, but the values were achieved by different mechanisms and driven by G × E effects for leaf area/sapwood area (Al/As), shoot length (L), specific conductivity (Ks) and leaf-specific conductivity (Kl). Dry sources achieved higher kl in the dry site through higher Kl (via a lower Al/As and no change in Ks) with no difference in L. Wet sources achieved higher kl at the dry site through no difference in Kl (via no effect on Al/As, despite decreases in Al and As, and lower Ks) with lower L. Vulnerability to embolism (measured as percentage loss of conductivity at 4 MPa) had no G effect but an E effect, with slightly lower values at the dry site. Specific leaf area had G and E effects, with lower values for the dry sources and site. There were no G or E effects on wood density. The different responses of dry and wet sources to site aridity suggest that populations are differentially adapted to the aridity of growing sites. Population variation in response to aridity should be considered when selecting seed sources for establishing forests for future climates.
Is strongyloidiasis currently autochthonous in Croatia? A retrospective study
Authors: Balen Topić Mirjana , Marjanović Ena , Tomasović Domagoj , Sviben Mario 
Published: September 2021

Abstract

Background
Autochthonous human infections with Strongyloides stercoralis have been well documented in many European regions. By exploring patients’ data, we aimed to find elements for its current endemicity in Croatia.

Methods
This retrospective descriptive study analysed epidemiological and clinical data of patients treated for strongyloidiasis from January 2010 to May 2019 at a teaching hospital in Zagreb, Croatia. The diagnosis was made by direct methods using light microscopy and/or serology.

Results
Among 65 patients with strongyloidiasis, 60% were men, and 78.5% were 50–79 y of age. The sensitivity of the examination of three stool samples after concentration, saline provocation and serology was 26.2, 80.7 and 86.2%, respectively. Clinical presentation included asymptomatic patients with eosinophilia (41.5%), chronic symptomatic infection (33.8%), acute infection (18.5%) and hyperinfection (6.2%). Twenty patients (30.8%) were immunosuppressed; among four of whom developed hyperinfection, two died. Initially 71.7% of patients were treated with albendazole and 13.3% with ivermectin, with an equal parasitological cure rate (72.2% and 75%; p=0.09). In 11 patients, acute infection was autochthonous in its origin.

Conclusions
Strongyloidiasis is currently endemic in Croatia and immunosuppressed travellers to this region should be advised to take precautions. Patients undergoing immunosuppression and organ donors from Croatia should be screened.
Learnings from two independent malaria elimination demonstration projects in India
Authors: Rajvanshi Harsh , Mishra Kirti , Bharti Praveen K , Sandhibigraha Debakanta , Nisar Sekh , Jayswar Himanshu , Das Aparup , Pradhan Madan M , Mohapatra Pradipta K , Govil Pallavi Jain , Kshirsagar Nilima , Dash Aditya P , Singh Shrinath , Sahu Ram Shankar , Kaur Harpreet , Dhingra Neeraj , Khan Azadar , Lal Altaf A 
Published: September 2021

Abstract

Problem
India and sub-Saharan Africa contributes about 85% of the global malaria burden, and India is committed to eliminating malaria by 2030.

Approach
Two novel initiatives—the Malaria Elimination Demonstration Project (MEDP) in Madhya Pradesh and Durgama Anchalare Malaria Nirakaran (DAMaN) in Odisha—were initiated independently to demonstrate that indigenous malaria can be eliminated in a short period of time.

Local setting
These initiatives focused on rural, tribal areas where there is a high malaria burden and complex epidemiology.

Relevant changes
The case management and vector control strategies used in these programmes were based on the national guidelines, with context-specific changes and introduction of accountability at management, operational, technical and financial levels. The MEDP achieved a 91% reduction in malaria cases and recorded zero transmission for 6 consecutive and a total of 9 mo. The DAMaN project brought about an 88% reduction in malaria cases.

Lessons learned
Malaria elimination will require robust surveillance and case management, monitoring of vector control interventions, community-centric information education communication and behaviour change communication initiatives and management controls, as well as regular internal and external reviews.
Genomic epidemiology reveals the reduction of the introduction and spread of SARS-CoV-2 after implementing control strategies in Republic of Korea, 2020
Authors: Kwon Jung-Hoon , Kim Jeong-Min , Lee Dong-hun , Park Ae Kyung , Kim Il-Hwan , Kim Da-Won , Kim Ji-Yun , Lim Noori , Cho Kyeong-Yeon , Kim Heui Man , Lee Nam-Joo , Woo SangHee , Lee Chae Young , No Jin Sun , Kim Junyoung , Rhee JeeEun , Han Myung-Guk , Rhie Gi-Eun , Yoo Cheon Kwon , Kim Eun-Jin 
Published: September 2021

Abstract
Genomic epidemiology is a core component in investigating the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, the efficacy of control strategies in South Korea was evaluated using genomic epidemiology based on viral genome sequences of 2,065 SARS-CoV-2 cases identified in South Korea from January 2020 to December 2020. Phylogenetic analysis revealed that the majority of viruses introduced from inbound travelers did not further spread throughout South Korea; however, four distinct subgroups (KR.1–4, belonging to B.1.497, B.1, K.1 and B.41) of viruses caused local epidemics. After the introduction of enhanced social distancing, the viral population size and daily case numbers decreased, and KR.2–4 subgroups were extinguished from South Korea. Nevertheless, there was a subsequent increase in KR.1 subgroups after the downgrading of social distancing level. These results indicate that the international traveler quarantine system implemented in South Korea along with social distancing measures efficiently reduced the introduction and spread of SARS-CoV-2, but it was not completely controlled. An improvement of control strategies will be required to better control SARS-CoV-2, its variants, and future pandemic viruses.
Polymyositis: does it really exist as a distinct clinical subset?
Authors: Leclair Valérie , Notarnicola Antonella , Vencovsky Jiri , Lundberg Ingrid E. 
Published: September 2021

Purpose of review
To summarize information on polymyositis; diagnosis, definitions, published data and opinions.

Recent findings
Polymyositis originally referred to inflammatory muscle diseases presenting with muscle weakness and inflammatory cell infiltrates on muscle tissue visible by microscopy. Over time and with improved technology to immunophenotype infiltrating inflammatory cells and characterize muscle fibres, the meaning of polymyositis changed and became more specific. There is ongoing controversy over the term polymyositis, with proponents for a strict definition based on histopathological and immunohistochemical features on muscle biopsies whereas others advocate for a broader clinical and histopathological phenotype. Over the past decades, the discovery of several myositis-specific autoantibodies together with distinct histopathological features have enabled the identification of new subsets previously labelled as polymyositis notably the antisynthetase syndrome and the immune-mediated necrotizing myopathies thus reducing the number of patients classified as polymyositis.

Summary
There are still a small number of patients among the idiopathic inflammatory myopathies that can be classified as polymyositis as discussed in this review but the entity is now considered relatively rare.
The dynamic organelle primary cilia: emerging roles in organ fibrosis
Authors: Bhattacharyya Dibyendu , Teves Maria E. , Varga John 
Published: September 2021

Purpose of review
Primary cilia, the antenna-like organelles on most mammalian cells, host key components of multiple morphogen signal transduction pathways. Mutations in genes responsible for primary cilia assembly and function generally result in pathological conditions known as ciliopathies, which underlie several diseases, including various forms of fibrosis. Primary cilia modulate cellular responses to extracellular cues, including TGF-β and morphogens, such as Hedgehog. Aberrant morphogen signaling is recognized as essential for the transition of mesenchymal progenitor cells to myofibroblasts, the key step in fibrosis. This article aims to provide a critical overview of recent developments and insights in primary cilia biology relevant to fibrosis.

Recent findings
Several studies have highlighted the association of altered primary cilia with various forms of fibrosis. In a rather complex manner, the presence of primary cilia seems to be required for initiation of myofibroblast transition, whereas its loss promotes myofibroblast transition at a later stage. Recent evidence also suggested that noncanonical functions of ciliary transport proteins may influence, such cellular transitions independently of primary cilia. The possibility of opposing signaling regulations being topologically separated between primary cilia and plasma membrane could also be critical for fibrosis.

Summary
Recent progress in the field suggests that primary cilia are critical mediators of the pathogenesis of fibrosis. Understanding the potential role of primary cilia in fibrosis and the underlying mechanisms may pave the way for entirely new approaches for fibrosis prevention and treatment of SSc.
Pulmonary Function Testing Pre–heart Transplant Predicts Posttransplant Survival
Authors: Lundgren Scott W. , Lowes Brian D. , Lyden Elizabeth , Zolty Ronald , Burdorf Adam , Hyden Marshall , Um John , Stoller Douglas A. 
Published: September 2021

Introduction.
Although pulmonary function testing (PFT) is typically performed for heart transplant evaluation, the prognostic utility of PFTs after transplantation is unknown. We evaluated whether PFT parameters were correlated with outcomes following heart transplantation.

Methods.
International Society for Heart and Lung Transplantation Thoracic Organ Transplant Registry data were utilized. Survival was assessed using Kaplan-Meier method and compared via log-rank test. Cox proportional hazard modeling was used to evaluate univariate and multivariate predictors of survival.

Results.
Eight hundred two patients pretransplant PFT data were available for evaluation. Forced expiratory volume in 1 s (FEV1) < 50% predicted (P < 0.0001), and forced vital capacity (FVC) < 50% predicted each had significantly higher mortality (P = 0.001) compared with patients with FEV1 or FVC 50%–80% or >80%. FEV1/FVC < 0.7 was not associated with increased mortality. FEV1 and FVC below 50% both predicted longer lengths of stay (P = 0.028 for FEV1 and P = 0.0075 for FVC). After adjusting for male gender, age, body mass index, smoking history, chronic obstructive pulmonary disease, creatinine, albumin, and total bilirubin, FEV1 < 50% (hazard ratio, 4.91; P < 0.0001; 95% confidence interval, 2.69-8.94) and FVC < 50% (hazard ratio, 2.75; P = 0.003; 95% confidence interval, 1.4-5.4) both remained independent predictors of mortality.

Conclusions.
Abnormal pulmonary function (FEV1 or FVC below 50% of predicted) pre–heart transplantation is associated with increased mortality and longer lengths of stay posttransplant.
Prolonged Normothermic Ex Vivo Kidney Perfusion Is Superior to Cold Nonoxygenated and Oxygenated Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts
Authors: Mazilescu Laura I. , Urbanellis Peter , Kaths Moritz J. , Ganesh Sujani , Goto Toru , Noguchi Yuki , John Rohan , Konvalinka Ana , Mucsi Istvan , Ghanekar Anand , Bagli Darius J. , Turgeon Julie , Karakeusian Rimbaud Annie , Hébert Marie-Josée , Dieudé Mélanie , Alleys Isabelle , Dore Etienne , Boilard Eric , Overkleeft Herman S. , Willems Lianne I. , Robinson Lisa A. , Selzner Markus 
Published: September 2021

Background.
The increased usage of marginal grafts has triggered interest in perfused kidney preservation to minimize graft injury. We used a donation after circulatory death (DCD) porcine kidney autotransplantation model to compare 3 of the most frequently used ex vivo kidney perfusion techniques: nonoxygenated hypothermic machine perfusion (non-oxHMP), oxygenated hypothermic machine perfusion (oxHMP), and normothermic ex vivo kidney perfusion (NEVKP).

Methods.
Following 30 min of warm ischemia, grafts were retrieved and preserved with either 16 h of non-oxHMP, oxHMP, or NEVKP (n = 5 per group). After contralateral nephrectomy, grafts were autotransplanted and animals were followed for 8 d. Kidney function and injury markers were compared between groups.

Results.
NEVKP demonstrated a significant reduction in preservation injury compared with either cold preservation method. Grafts preserved by NEVKP showed superior function with lower peak serum creatinine (NEVKP versus non-oxHMP versus oxHMP: 3.66 ± 1.33 mg/dL, 8.82 ± 3.17 mg/dL, and 9.02 ± 5.5 mg/dL) and more rapid recovery. The NEVKP group demonstrated significantly increased creatinine clearance on postoperative day 3 compared with the cold perfused groups. Tubular injury scores on postoperative day 8 were similar in all groups.

Conclusions.
Addition of oxygen during HMP did not reduce preservation injury of DCD kidney grafts. Grafts preserved with prolonged NEVKP demonstrated superior initial graft function compared with grafts preserved with non-oxHMP or oxHMP in a model of pig DCD kidney transplantation.