bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort study of the overall survival of patients with pancreatic cancer in a hospital of specialties of Quito-Ecuador in the period 2007–2017
Authors: Moreno Roca Andrés , Armijos Acurio Luciana , Jimbo Sotomayor Ruth , Céspedes Rivadeneira Carlos , Rosero Reyes Carlos , López Ayala Carlos 
Published: April 2021

Abstract

Objectives
Pancreatic cancers in most patients in Ecuador are diagnosed at an advanced stage of the disease, which is associated with lower survival. To determine the characteristics and global survival of pancreatic cancer patients in a social security hospital in Ecuador between 2007 and 2017.

Methods
A retrospective cohort study and a survival analysis were performed using all the available data in the electronic clinical records of patients with a diagnosis of pancreatic cancer in a Hospital of Specialties of Quito-Ecuador between 2007 and 2017. The included patients were those coded according to the ICD 10 between C25.0 and C25.9. Our univariate analysis calculated frequencies, measures of central tendency and dispersion. Through the Kaplan-Meier method we estimated the median time of survival and analyzed the difference in survival time among the different categories of our included variables. These differences were shown through the log rank test.

Results
A total of 357 patients diagnosed with pancreatic cancer between 2007 and 2017 were included in the study. More than two-thirds (69.9%) of the patients were diagnosed in late stages of the disease. The median survival time for all patients was of 4 months (P25: 2, P75: 8).

Conclusions
The statistically significant difference of survival time between types of treatment is the most relevant finding in this study, when comparing to all other types of treatments.
The British Fertiliser Manufacturers’ Association: Struggle for Survival 1870‒1930
Authors: Moss Michael 
Published: April 2021

Abstract
Most firms in the British fertiliser industry of the 19th century were small and combined other activities, such as seed merchants, millers, manufacturers of sulphuric acid and in one case explosives. In the heyday of high farming there was almost no co-operation and no attempt to achieve economy of scale through merger and amalgamation. In 1875 just before the onset of the depression the Chemical Manure Manufacturers’ Association was formed to fix prices and address the challenges posed by proposed Government regulation of what was after all a noxious industry. This story mirrors much of British industry, where implicit (price-fixing) cartels failed and individual firms rejected collaboration in favour of what seems an irrational commitment to a free market ideology that was transparently misplaced.
Oilseed Cakes in Italy and France: Opportunities and Difficulties of a Market (late 19th and first half of the 20th Century)
Authors: Andreoni Luca 
Published: April 2021

Abstract
This paper addresses the trade and commercialisation of oilseed cakes (residues from the extraction of oils) and press cakes in Italy and France during the last decades of the 19th century and in the first half of the 20th century. It tries to demonstrate that the diffusion of oilseed cakes for livestock, a distinctive sign of the intensification of breeding that involved all of Europe, or as organic fertilisers, took place at the crossroads of multiple dynamics. Trade policy of the states, industrial choices and development paths of the different rural worlds help to explain the variations in timing, spatial scale and methods used. The spread of oilseed cakes confirms that the modernisation of European agriculture happened on different and interrelated fronts.
Synchronous primary malignancy of colon cancer and mantle cell lymphoma: A case report
Authors: Liao Haihong , Song Pengtao , Qi Quan , Jiang Yizhen , Han Shuwen , Pan Yuefen , Liu Yulong 
Published: April 2021

Abstract
Multiple primary malignancies in a single patient are relatively rare; however, the frequency of this has increased significantly in recent decades. Here, we retrospectively reported an unusual case of a 70-year-old man who was admitted to the hospital with mantle cell lymphoma (MCL) and colon cancer and aimed to explore measures to reduce missed diagnosis. Based on the data, the investigation of the related literatures, colonoscopy examination, and abdominal computed tomography (CT) scan were conducted for the detection of colon cancer. Following this, a precise diagnosis of MCL was confirmed by immunohistochemistry and bone marrow biopsy, which were performed to analyze the clinical characteristics and essentials for the diagnosis and differential of the disease. The results of colonoscopy showed that the patient had colon cancer, while the abdominal CT scan demonstrated colon cancer accompanied by multiple lymphadenopathy throughout the entire body. Besides, the results of immunohistochemistry confirmed that the patient suffered from MCL. The bone marrow biopsy revealed the active hematopoietic tissue hyperplasia but no tumor issue involvement in the bone marrow. In conclusion, our study combined the analysis and summary of the diagnosis and treatment of the colon cancer with MCL to provide clinical guidance for the rare multiple primary malignancy.
Die Existenzweisen eines Fötus
Authors: Völkle Laura 
Published: April 2021

ZusammenfassungTotgeborene sind Entitäten mit einem doppelt prekären Status, denn ihre Karriere alsPersonist bereits vorüber, bevor ihre Existenz alsMenschrichtig begonnen hat. Dieses Charakteristikum nutzt der Beitrag, um nach dem situierten Zusammenspiel von Prozessen der De/Personalisierung und De/Humanisierung zu fragen. Die Analyse verfolgt anhand ethnografischer Beschreibungen den Weg eines totgeborenen Fötus von seiner Entbindung im Kreißsaal bis zu seiner Beisetzung und nimmt dessen ontologisches Changieren zwischen unterschiedlichen Existenzweisen in den Blick. Damit schließt der Beitrag an die Debatte um die „Grenzen des Sozialen“ an und fasst Menschen und Personen als kontingente Phänomene, nach denen empirisch zu fragen ist. Er will mit seiner Analyse zu einer mikrosoziologischen Komplexitätsentfaltung von Grenzziehungsprozessen am Lebensanfang beitragen.
CeTiO2N oxynitride perovskite: paramagnetic 14N MAS NMR without paramagnetic shifts
Authors: Ma Zili , Lu Can , Chen Jianhong , Rokicińska Anna , Kuśtrowski Piotr , Coridan Robert , Dronskowski Richard , Slabon Adam , Jaworski Aleksander 
Published: April 2021

Abstract

14N magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectra of diamagnetic LaTiO2N perovskite oxynitride and its paramagnetic counterpart CeTiO2N are presented. The latter, to the best of our knowledge, constitutes the first high-resolution 14N MAS NMR spectrum collected from a paramagnetic solid material. The unpaired 4f-electrons in CeTiO2N do not induce a paramagnetic 14N NMR shift. This is remarkable given the direct Ce−N contacts in the structure for which ab initio calculations predict substantial Ce→14N contact shift interaction. The same effect is revealed with 14N MAS NMR for SrWO2N (unpaired 5d-electrons).
ЖИТИ У СОЦМІСТІ ЗАРАЗ: МІЖ СПАДЩИНОЮ ТА ОНОВЛЕННЯМ
Authors: Боженко Анастасія , Суховєєва Олександра 
Published: April 2021

У статті розглянуто проблеми участі місцевої громади у ревіталізаційних процесах, які відбуваються в історичному ареалі Соцміста, або району ХТЗ. Район було частково реалізовано у 1930-ті рр. за проєктом архітектора Павла Альошина. У післявоєнну добу від концепції Соцміста відмовилися, однак сам район і надалі розвивався як промзона. Було зведено низку нових потужних підприємств важкої промисловості. В сучасному контексті навіть за умов модернізації підприємств частина виробничих потужностей стає незатребуваною. З іншого боку, деіндустріалізацію потрібно розглядати у прив’язці до селітебної зони, тому в нашій статті ми фокусуємося на тих активістських ініціативах, які нині відбуваються у районі ХТЗ. Історіографія проблеми складається з досліджень історичного й містобудівного контексту, соціальної складової та теоретичних робіт із тематики індустріальної спадщини. Основа джерельної бази – дописи активістів у соціальній мережі «Фейсбук», містобудівна документація та законодавча база.
Karakteristik Molekuler Kelelawar (Microchiroptera), berdasarkan DNA Mitokondria (Gen COI) di Gua Sukabumi dan Sentul Jawa Barat
Authors: Afifah Ismayati , Solihin Dedy Duryadi , Sunkar Arzyana 
Published: April 2021

AbstrakCytochrome Oxidase I (COI) merupakan salah satu gen mitokondria untuk membantu konstruksi dari pohon filogeni yang dapat bertindak sebagai gen marker. Gen COI memiliki keakuratan dalam mengidentifikasi spesies dan umumnya digunakan sebagai “DNA Barcoding”. Informasi mengenai karakteristik genetik berdasarkan DNA mitokondria pada kelelawar di Sukabumi dan Sentul belum banyak dilaporkan. Tujuan dari penelitian ini untuk mengetahui keragaman genetik kelelawar berdasarkan DNA mitokondria dengan penanda Cytochrome Oxidase I (COI) sebagai DNA barcoding. Isolasi DNA total dilakukan menggunakan Kit Dneasy® Blood and Tissue Kit cat no 69504 (50) berdasarkan prosedur Spin-Column Protocol dengan modifikasi. Hasil penelitian ini menunjukkan bahwa gen COI telah berhasil mengidentifikasi karakteristik spesies. Dua haplotipe didapatkan dari masing-masing populasi. Berdasarkan barcode DNA menunjukkan populasi Sukabumi merupakan spesies Chaerephon plicatus dengan nilai identitas genetik sebesar 97,08%, sedangkan populasi Sentul menunjukkan perbedaan secara genetik dengan spesies Hipposideros larvatus dengan nilai identitas genetik sebesar 94,85%. Identifikasi secara genetik dengan menggunakan gen COI menunjukkan bahwa kelelawar yang berasal Sukabumi adalah spesies Chaerephon plicatus dengan jarak genetik sebesar 3,1%. Kelelawar yang berasal dari Sentul memiliki kedekatan dengan spesies Hipposideros larvatus namun memiliki jarak genetik sebesar 5,2%. AbstractCytochrome Oxidase I (COI) is one of the mitochondrial genes to help the construction of phylogeny trees that can act as marker genes. The COI gene has accuracy in identifying species and is commonly used as "DNA Barcoding". Information about genetic characteristics based on mitochondrial DNA in bats in Sukabumi and Sentul has not been widely reported. The purpose of this study was to determine the genetic diversity of bats based on Mitochondrial DNA with Cytochrome Oxidase I (COI) markers as DNA barcoding. Total DNA isolation was carried out using the Dneasy® Blood and Tissue Kit paint no. 69504 (50) based on the Spin-Column Protocol procedure with modifications. The results of this study indicate that the COI gene has successfully identified species characteristics. Two haplotypes were obtained from each population. Based on DNA barcodes, the population of Sukabumi is a species of Chaerephon plicatus with a genetic identity value of 97.08%, while the Sentul population shows genetic differences with the Hipposideros larvatus species with a genetic identity value of 94.85%. Genetic identification using the COI gene shows that the bats originating from Sukabumi is a spesies Chaerephon plicatus with a genetic distance of 3.1%. The bats originating from Sentul are closely related to the species Hipposideros larvatus but have a genetic distance of 5.2%.
Ethnomedicine Of Medicinal Plants Used By Tribal Community In Kaliki Village, Merauke - Papua
Authors: Ibo Leberina Kristina , Arifa Nissa 
Published: April 2021

AbstrakPapua memiliki keanekaragaman hayati yang tinggi dengan jenis hutan yang lengkap dan flora endemik yang tidak ditemukan di daerah lain, serta pengetahuan tradisional tumbuhan obat masyarakat Papua sangat beragam. Namun pengetahuan tersebut belum diungkapkan dan di dokumentasikan dengan baik, seperti pengetahuan masyarakat suku Marind di Kampung Kaliki Merauke yang merupakan salah satu suku terbesar yang menempati pesisir pantai hingga perbatasan Papua New Guinea. Penelitian etnomedisin tumbuhan obat dimaksudkan untuk mengungkapkan presepsi dan konsepsi masyarakat lokal dalam memahami kesehatan seperti pengunaan tumbuhan sebagai bahan obat, sekaligus untuk melakukan inventarisasi keanekaragaman jenis tumbuhan berguna untuk obat-obatan tradisional dan sebagai data awal untuk riset farmasi dalam menemukan senyawa baru yang berguna dalam pengobatan. Metode penelitian dilakukan melalui pendekatan emik dan etik juga melakukan wawancara secara terbuka dan pengamatan langsung di lapangan. Hasil penelitian menunjukan sebanyak 34 spesies dari 22 famili dikenali dan dimanfaatkan untuk menyembuhkan berbagai penyakit. Daun merupakan bagian tumbuhan yang paling banyak dimanfaatkan sebagai bahan obat yaitu sebanyak 18 spesies, kulit batang 8 spesies dan akar rimpang 3 spesies. Sebagian besar pengolahan tumbuhan obat melalui metode perebusan dan konsumsi langsung. Tumbuhan obat ini dimanfaatkan untuk pengobatan 15 jenis penyakit. Persalinan dan diare merupakan pengobatan yang paling banyak memanfaatkan tumbuhan obat. AbstractPapua is rich in biodiversity with several forest types and endemic flora that cannot be found anywhere else in the world. Furthermore, diverse traditional knowledge of medicinal plants are already used by tribal community in Papua. However, this knowledge has not been published and well documented. For example, the knowledge of the Marind Tribe in Kaliki Village, Merauke, which is one of the largest tribes living on the coast to the border of Papua New Guinea. Research of ethnomedicine on medicinal plants is intended to reveal the perception and conception of local communities in understanding health, such as the utilization of plants as medicine, inventory of plant used in traditional medicines, and preliminary data for pharmaceutical research to find new compounds for drug discovery. This study used emic and ethical approaches, open-ended interviews, and direct field observations. According to study result, a total of 34 species from 22 families were identified and used to cure various diseases. It was found that plant parts most widely used as medicinal ingredients were leaves of 18 species, bark of 8 species, and rhizome of 3 species. Moreover, medicinal plants were normally boiled or processed for direct consumption. The medicinal plant was used to treat 15 species of diseases. In addition, medicinal plants were mostly used in childbirth care and treating diarrhea.
Prevalence and Predictors of Medical Complexity in a National Sample of VLBW Infants
Authors: Hannan Kathleen E. , Bourque Stephanie Lynn , Palmer Claire , Tong Suhong , Hwang Sunah Susan 
Published: April 2021

BACKGROUND AND OBJECTIVES:Very low birth weight (VLBW) infants are at high risk for morbidities beyond the neonatal period and ongoing use of health care. Specific morbidities have been studied; however, a comprehensive landscape of medical complexity in VLBW infants has not been fully described. We sought to (1) describe the prevalence of complex chronic conditions (CCCs) and (2) determine the association of demographic, hospital, and clinical factors with CCCs and CCCs or death.METHODS:This retrospective cross-sectional analysis of discharge data from the Kids’ Inpatient Database (2009–2012) included infants with a birth weight &lt;1500 g and complete demographics. Outcomes included having CCCs or having either CCCs or dying. Analyses were weighted; univariate and multiple logistic regression models were used to estimate unadjusted and adjusted odds ratios. A dominance analysis with Cox-Snell R2 determined the relative contribution of demographic, hospital, and clinical factors to the outcomes.RESULTS:Among our weighted cohort of &gt;78 000 VLBW infants, &gt;50% had CCCs or died. After adjustments, the prevalence of CCCs or CCCs or death differed by sex, race and ethnicity, hospital location, US region, receipt of surgery, transfer status, and birth weight. Clinical factors accounted for the highest proportion of the model’s ability to predict CCCs and CCCs or death at 93.3% and 96.3%, respectively, whereas demographic factors were 11.5% and 2.3% and hospital factors were 5.2% and 1.4%, respectively.CONCLUSIONS:In this nationally representative analysis, medical complexity is high among VLBW infants. Varying contributions of demographic, hospital, and clinical factors in predicting medical complexity offer opportunities to investigate future interventions to improve care delivery and patient outcomes.
‘I’m doing it for myself’: Using a smartphone-based exercise service during the COVID-19 lockdown in the Faculty of Health Sciences, University of the Witwatersrand, South Africa
Authors: Constantinou Demitri , Torres Georgia , Neophytou Natalia , Fourie Peter , Buntting Xenia , Gradidge Philippe 
Published: April 2021

Background: Sufficient physical activity (PA) lowers poor health outcomes, with data showing these protective effects in populations under varying levels of lockdown during the COVID-19 pandemic. The advent of online PA programmes has created novel opportunities to offset the deleterious effects of inactivity. However, data are limited and the readiness and acceptance of such technology is unknown. These authors nevertheless noted an opportunity to investigate this approach based on promising emerging data at the time of the hard lockdown in South Africa.
Objective: This exploratory study investigated the engagement and perceptions of a smartphone application to promote health and fitness in a sample of employees at a South African university.
Methods: Employed members of staff (n=15) of the University of the Witwatersrand were recruited through email invitation during the hard Level 5 COVID-19 lockdown in 2020. Individualised home-based PA programmes were prescribed through a mobile application for a period of eight weeks. Researchers qualified in Biokinetics provided online supervision of the exercise sessions during the intervention. Participants were asked to complete a self-reported questionnaire about their use of the application. Thematic analysis was used to understand these responses.
Results: Lack of motivation was perceived to have a negative effect on participation in the online PA programme. Only one participant reported using the mobile application consistently during the study period, while half of the participants reported having trouble with the usage of the application. The participants frequently mentioned the need for technical support and further engagement from the clinicians supervising the PA programme to ensure use and progression. Staff identified issues with connectivity and already having too many phone applications (apps) amongst the reasons for the technical difficulties.
Conclusion: This study demonstrates the challenges and potential for the uptake of online PA interventions during COVID-19 and, despite its small sample size, the data provide important lessons learned that will be used as information in further investigations.
Methotrexate in psoriasis treatment: a single-center retrospective study (2018–2020)
Authors: Olisova Olga Yu. , Anpilogova Ekaterina M. 
Published: April 2021

BACKGROUND: Despite the wide range of therapeutic options for moderate-to-severe psoriasis, dermatologists still experience some difficulties in its treatment. To date, methotrexate (MTX) is the most commonly prescribed systemic drug for the treatment of psoriasis worldwide. Given its low cost and good effectiveness, this drug has been continuously used along with recently developed highly effective biological drugs. According to international guidelines, MTX is a drug of choice for the treatment of moderate-to-severe psoriasis.
AIM: To evaluate the efficacy and safety of MTX in the treatment of moderate-to-severe psoriasis.
MATERIALS AND METHODS: We conducted a retrospective study on patients with psoriasis who had been admitted to the Dermatology Department of Sechenov University in 20182020. Based on electronic medical documents of the patients, we analyzed the demographic characteristics, disease duration, comorbidities, psoriasis severity before and after treatment with MTX, and its side effects.
RESULTS: The study included 655 patients with moderate (373; 57%) and severe (282; 43%) psoriasis. Of these patients, 279 (42.6%) were women aged 1879 years, and 376 (57.4%) were men aged 1886 years (median age: 44.9 and 41.6 years, respectively). The duration of stay in the hospital varied from 17 days to 21 days. In all cases, topical therapy was performed in addition to systemic drugs administration or phototherapy. The most commonly prescribed medication was MTX 326 (49.7%) in a dose of 25 mg/week. A total of 29 patients received MTX as monotherapy. However, the drug was most often prescribed in combination with phototherapy: MTX + PUVA (n = 140) and MTX + UVB-311 nm (n = 157). At the time of discharge from the hospital, 53% of patients in the MTX group had improved, 47% had a significant improvement. in the MTX group + PUVA in 10.3; 75.7; 14% of patients, respectively; in the MTX + UVB-311 nm group in 17.4; 71.2; 11.4% of patients, respectively. The side effects were mild and did not lead to treatment discontinuation.
CONCLUSION: MTX is a highly effective therapeutic option with a good safety profile and is a confirmed drug of choice for the treatment of moderate-to-severe psoriasis.
Features of the legal regulation of the use of biometric personal data
Authors: Petrova Daria A. , Martianov Nikita R. 
Published: April 2021

In this paper, the authors highlight the legal basis for the use of biometric personal data, and also pay attention to the main initiative of the state in this area: the creation of a unified biometric system.
The study is particularly relevant in connection with the release of the new Federal law No. 168-FZ on June 8, 2020: On the unified Federal information register containing information about the population of the Russian Federation. In particular, an acute problem is the ability to integrate information from the unified biometric system and the Federal register that is being created.
Patrimônio, Cidade e o Papel do Desenho Urbano
Authors: Capestro Antonio 
Published: April 2021

A conservação e valorização do Patrimônio Urbano constitui um dos desafios mais significativos dos últimos cinquenta anos, assumindo uma considerável importância tanto no sentido da preservarção e salvaguarda de valores compartilhados como na valorização da herança do passado enquanto recurso. Junto ao binômio clássico - e já bastante debatido - do projeto do patrimônio, o artigo propõe outro enfoque: a importância do patrimônio do projeto, uma vez que aquilo que se considera como Patrimônio é produto de um processo dinâmico que transfigura as permanências do passado para renovar sua contribuição no futuro. Ao não intervir sobre o patrimônio, estamos contradizendo sua própria essência. O artigo apresenta uma abordagem teórica que alimenta e é alimentada pela prática, focando na noção de patrimônio do projeto tanto na dimensão da pesquisa acadêmica quanto no desenho urbano e na intervenção sobre/no espaço, buscando um equilíbrio entre a preservação e uma constante evolução de usos e fruições que não dependem apenas de seu contexto geográfico e social, mas de fluxos mundiais, como o do turismo. Palavras-chave: Patrimônio; Cidade; Desenho Urbano.