bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraining the effects of dynamic topography on the development of Late Cretaceous Cordilleran foreland basin, western United States
Authors: Li Zhiyang , Aschoff Jennifer 
Published: May 2021

AbstractDynamic topography refers to the vertical deflection (i.e., uplift and subsidence) of the Earth's surface generated in response to mantle flow. Although dynamic subsidence has been increasingly invoked to explain the subsidence and migration of depocenters in the Late Cretaceous North American Cordilleran foreland basin (CFB), it remains a challenging task to discriminate the effects of dynamic mantle processes from other subsidence mechanisms, and the spatial and temporal scales of dynamic topography is not well known. To unravel the relationship between sedimentary systems, accommodation, and subsidence mechanisms of the CFB through time and space, a high-resolution chronostratigraphic framework was developed for the Upper Cretaceous strata based on a dense data set integrating &gt;600 well logs from multiple basins/regions in Wyoming, Utah, Colorado, and New Mexico, USA. The newly developed stratigraphic framework divides the Upper Cretaceous strata into four chronostratigraphic packages separated by chronostratigraphic surfaces that can be correlated regionally and constrained by ammonite biozones. Regional isopach patterns and shoreline trends constructed for successive time intervals suggest that dynamic subsidence influenced accommodation creation in the CFB starting from ca. 85 Ma, and this wave of subsidence increasingly affected the CFB by ca. 80 Ma as subsidence migrated from the southwest to northeast. During 100–75 Ma, the depocenter migrated from central Utah (dominantly flexural subsidence) to north-central Colorado (dominantly dynamic subsidence). Subsidence within the CFB during 75–66 Ma was controlled by the combined effects of flexural subsidence induced by local Laramide uplifts and dynamic subsidence. Results from this study provide new constraints on the spatio-temporal footprint and migration of large-scale (&gt;400 km × 400 km) dynamic topography at an average rate ranging from ~120 to 60 km/m.y. in the CFB through the Late Cretaceous. The wavelength and location of dynamic topography (subsidence and uplift) generated in response to the subduction of the conjugate Shatsky Rise highly varied through both space and time, probably depending on the evolution of the oceanic plateau (e.g., changes in its location, subduction angle and depth, and buoyancy). Careful, high-resolution reconstruction of regional stratigraphic frameworks using three-dimensional data sets is critical to constrain the influence of dynamic topography. The highly transitory effects of dynamic topography need to be incorporated into future foreland basin models to better reconstruct and predict the formation of foreland basins that may have formed under the combined influence of upper crustal flexural loading and dynamic subcrustal loading associated with large-scale mantle flows.
Mid-Cretaceous thick carbonate accumulation in Northern Lhasa (Tibet): eustatic vs. tectonic control?
Authors: Xu Yiwei , Hu Xiumian , Garzanti Eduardo , BouDagher-Fadel Marcelle , Sun Gaoyuan , Lai Wen , Zhang Shijie 
Published: May 2021

Abstract
Widespread accumulation of thick carbonates is not typical of orogenic settings. During the mid-Cretaceous, near the Bangong suture in the northern Lhasa terrane, the shallow-marine carbonates of the Langshan Formation, reaching a thickness up to ~1 km, accumulated in an epicontinental seaway over a modern area of 132 × 103 km2, about half of the Arabian/Persian Gulf. The origin of basin-wide carbonate deposits located close to a newly formed orogenic belt is not well understood, partly because of the scarcity of paleogeographic studies on the evolution of the northern Lhasa. Based on a detailed sedimentological and stratigraphic investigation, three stages in the mid-Cretaceous paleogeographic evolution of northern Lhasa were defined: (1) remnant clastic sea with deposition of Duoni/Duba formations (Early to early Late Aptian, ca. 125–116 Ma); (2) expanding carbonate seaway of Langshan Formation (latest Aptian–earliest Cenomanian, ca. 116–99 Ma); and (3) closure of the carbonate seaway represented by the Daxiong/Jingzhushan formations (Early Cenomanian to Turonian, ca. 99–92 Ma). Combined with data on tectonic subsidence and eustatic curves, we emphasized the largely eustatic control on the paleogeographic evolution of the northern Lhasa during the latest Aptian–earliest Cenomanian when the Langshan carbonates accumulated, modulated by long-term slow tectonic subsidence and high carbonate productivity.
Novel strategy to personalise use of ibuprofen for closure of patent ductus arteriosus in preterm neonates
Authors: Samiee-Zafarghandy Samira , van Donge Tamara , Fusch Gerhard , Pfister Marc , Jacob George , Atkinson Andrew , Rieder Michael J , Smit Cornelis , Van Den Anker John 
Published: May 2021

ObjectiveExploration of a novel therapeutic drug monitoring (TDM) strategy to personalise use of ibuprofen for closure of patent ductus arteriosus (PDA) in preterm neonates.DesignProspective, single-centre, open-label, pharmacokinetics study in preterm neonates.SettingNeonatal intensive care unit at McMaster Children’s Hospital.PatientsNeonates with a gestational age ≤28+6 weeks treated with oral ibuprofen for closure of a PDA.MethodsPopulation pharmacokinetic parameters, concentration-time profiles and exposure metrics were obtained using pharmacometric modelling and simulation.Main outcome measureAssociation between ibuprofen plasma concentrations measured at various sampling time points on the first day of treatment and attainment of the target exposure over the first 3 days of treatment (AUC0–72h >900 mg·hour/L).ResultsTwenty-three preterm neonates (median birth weight 780 g and gestational age 25.9 weeks) were included, yielding 155 plasma ibuprofen plasma samples. Starting from 8 hours’ postdose on the first day, a strong correlation between ibuprofen concentrations and AUC0–72h was observed. At 8 hours after the first dose, an ibuprofen concentration >20.5 mg/L was associated with a 90% probability of reaching the target exposure.ConclusionWe designed a novel and practical TDM strategy and have shown that the chance of reaching the target exposure (AUC0–72h >900 mg·hour/L) can be predicted with a single sample collection on the first day of treatment. This newly acquired knowledge can be leveraged to personalise ibuprofen dosing regimens and improve the efficacy of ibuprofen use for pharmacological closure of a PDA.
Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)
Authors: Lee Jonathan W J , Zhu Feng , Srivastava Supriya , Tsao Stephen KK , Khor Christopher , Ho Khek Yu , Fock Kwong Ming , Lim Wee Chian , Ang Tiing Leong , Chow Wan Cheng , So Jimmy Bok Yan , Koh Calvin J , Chua Shijia Joy , Wong Andrew S Y , Rao Jaideepraj , Lim Lee Guan , Ling Khoon Lin , Chia Chung-King , Ooi Choon Jin , Rajnakova Andrea , Yap Wai Ming , Salto-Tellez Manuel , Ho Bow , Soong Richie , Chia Kee Seng , Teo Yik Ying , Teh Ming , Yeoh Khay-Guan 
Published: May 2021

ObjectiveTo investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC.MethodsA prospective, longitudinal and multicentre study was carried out in Singapore. The study participants comprised 2980 patients undergoing screening gastroscopy with standardised gastric mucosal sampling, from January 2004 and December 2010, with scheduled surveillance endoscopies at year 3 and 5. Participants were also matched against the National Registry of Diseases Office for missed diagnoses of early gastric neoplasia (EGN).ResultsThere were 21 participants diagnosed with EGN. IM was a significant risk factor for EGN (adjusted-HR 5.36; 95% CI 1.51 to 19.0; p<0.01). The age-adjusted EGN incidence rates for patients with and without IM were 133.9 and 12.5 per 100 000 person-years. Participants with OLGIM stages III–IV were at greatest risk (adjusted-HR 20.7; 95% CI 5.04 to 85.6; p<0.01). More than half of the EGNs (n=4/7) attributed to baseline OLGIM III–IV developed within 2 years (range: 12.7–44.8 months). Serum trefoil factor 3 distinguishes (Area Under the Receiver Operating Characteristics 0.749) patients with OLGIM III–IV if they are negative forH. pylori. Participants with OLGIM II were also at significant risk of EGN (adjusted-HR 7.34; 95% CI 1.60 to 33.7; p=0.02). A significant smoking history further increases the risk of EGN among patients with OLGIM stages II–IV.ConclusionsWe suggest a risk-stratified approach and recommend that high-risk patients (OLGIM III–IV) have endoscopic surveillance in 2 years, intermediate-risk patients (OLGIM II) in 5 years.
Histological background of dedifferentiated solitary fibrous tumour
Authors: Yamada Yuichi , Kohashi Kenichi , Kinoshita Izumi , Yamamoto Hidetaka , Iwasaki Takeshi , Yoshimoto Masato , Ishihara Shin , Toda Yu , Ito Yoshihiro , Kuma Yuki , Yamada-Nozaki Yui , Koga Yutaka , Hashisako Mikiko , Kiyozawa Daisuke , Kitahara Daichi , Narutomi Fumiya , Kuboyama Yusuke , Nakamura Takahito , Inoue Takeshi , Mukai Munenori , Honda Yumi , Toyokawa Gouji , Tsuchihashi Kenji , Fushimi Fumiyoshi , Taguchi Kenichi , Nishiyama Kenichi , Tamiya Sadafumi , Oshiro Yumi , Furue Masutaka , Nakashima Yasuharu , Suzuki Satoshi , Iwaki Toru , Oda Yoshinao 
Published: May 2021

AimsDedifferentiation is a histological phenomenon characterised by abrupt transition of histology to a sarcomatous component with high-grade malignant potential in solitary fibrous tumour (SFT). The authors histologically reviewed SFT cases to reveal the histological background of dedifferentiated SFTs.MethodsClinicopathological and histopathological findings of 145 SFT cases were reviewed. Immunohistochemical staining and genetic analysis were also performed.ResultsThe non-dedifferentiated components showed a cellular component in 45 of 145 (31%), high mitotic rate (≥4/10 high-powered field) in 12 of 145 (8.2%) tumours, necrosis in 7 of 145 (4.8%) tumours, multinodular growth pattern in 39 of 132 (29.5%) available tumours and intratumoural fibrous septa in 37 of 131 (28.2%). Immunohistochemically, the non-dedifferentiated components were positive for CD34 in 128 of 141 (90.7%), bcl-2 in 101 of 133 (75.9%), nuclear pattern of β-catenin in 64 of 127 (50.3%) and p16 in 22 of 140 (15.7%). Loss of Rb protein expression was detected in 17 of 110 (15.4%) cases. Statistically, cellular component, multinodular structure, p16 overexpression and Rb protein loss were significantly associated with dedifferentiation. Moreover, cellular component and multinodular structure were significantly associated with p16 overexpression and Rb protein loss. All the non-deddifferentiated components showed wild type of p53 expression. The dedifferentiated components of all 10 dedifferentiated tumours presented positivity for p16 in 9 of 10 (90%) and mutational type of p53 in 5 of 10 (50%). Loss of Rb protein expression was detected in 6 of 10 (60%).ConclusionsThe authors propose that cellular or multinodular transformation may be associated with dedifferentiation. They also suggest that cellular and multinodular transformation may be associated with p16 overexpression and Rb downregulation.
WEB device for treatment of posterior communicating artery aneurysms
Authors: Aguiar Guilherme , Caroff Jildaz , Mihalea Cristian , Cortese Jonathan , Girot Jean-Baptiste , Elawady Ahmed , Vergara Martinez Jeickson , Ikka Léon , Gallas Sophie , Chalumeau Vanessa , Ozanne Augustin , Moret Jacques , Spelle Laurent 
Published: May 2021

BackgroundWoven EndoBridge (WEB) device treatment of wide-neck bifurcation aneurysms has proved to be safe and effective, but the use of these devices in sidewall aneurysms has been reported only in a small number of case series.ObjectiveTo report our results in a cohort of consecutive patients in whom a WEB device was used as first-line treatment for posterior communicating artery (PComA) aneurysms.MethodsWe conducted a retrospective analysis of a prospectively maintained database of PComA aneurysms treated with a WEB device in our institution from June 1, 2012 to November 15, 2020. Clinical and radiological findings were evaluated at immediate and last follow-up.ResultsA total of 219 aneurysms were treated with a WEB device, including 15 PComA aneurysms in 15 patients, 10 of which were ruptured. Aneurysms were wide necked, with a mean aspect ratio of 1.6 (range 0.7–3.0) and a mean neck size of 4.2 mm (range 2.6–7.4 mm). No intraoperative rupture occurred and only one thromboembolic event was noted. Among the group with at least a 3-month digital subtraction angiography (DSA) follow-up, complete and adequate occlusion were obtained in 54% and 72%, respectively (average follow-up 13 months). Re-treatment was needed for two initially ruptured aneurysms. No procedure-related morbidity or mortality was reported.ConclusionThis series suggests the high safety profile of WEB devices even when used in off-label indications. Treatment with these devices seems to be a valuable strategy for ruptured wide-neck PComA aneurysms, avoiding the need for antiplatelet medication. However, occlusion rates should be investigated in further larger studies.
Efficacy of perineural versus intravenous dexmedetomidine as a peripheral nerve block adjunct: a systematic review
Authors: Hussain Nasir , Brummett Chad M , Brull Richard , Alghothani Yousef , Moran Kenneth , Sawyer Tamara , Abdallah Faraj W 
Published: May 2021

BackgroundDexmedetomidine is an effective local anesthetic adjunct for peripheral nerve blocks. The intravenous route for administering dexmedetomidine has been suggested to be equally effective to the perineural route; but comparative evidence is conflicting.ObjectivesThis evidence-based review evaluated trials comparing the effects of intravenous to perineural dexmedetomidine on peripheral nerve block characteristics in adult surgical patients. Our primary aim was to evaluate the durations of sensory and motor blockade. Duration of analgesia, onset times of sensory and motor blockade, analgesic consumption, rest pain, and dexmedetomidine-related adverse events were evaluated as secondary outcomes.Evidence reviewWe sought randomized trials comparing the effects of intravenous to perineural dexmedetomidine on peripheral nerve block characteristics. The Cochrane Risk of Bias tool and the Grades of Recommendation, Assessment, Development, and Evaluation criteria was used to evaluate the quality of evidence for when an outcome was reported by at least three studies.ResultsTen studies compared intravenous and perineural dexmedetomidine in the setting of upper extremity blocks (seven), lower extremity blocks (two), and truncal block (one). The doses of dexmedetomidine supplementing long-acting local anesthetics varied between a predetermined dose (50 μg) and a weight-based dose (0.5 μg/kg–1.0 μg/kg). Clinical diversity precluded quantitative pooling; and evidence is presented as a systematic review. Compared with the intravenous route, moderate quality evidence found that perineural dexmedetomidine prolonged the duration of sensory blockade in four of six trials and motor blockade in five of seven trials. Perineural dexmedetomidine also hastened the onset of sensory and motor blockade in three of six trials. No differences were reported for the remaining outcomes; and intravenous dexmedetomidine was not superior for any outcome in any of the trials.ConclusionsModerate quality evidence appears to suggest that intravenous dexmedetomidine is an inferior peripheral nerve block adjunct compared with perineural dexmedetomidine. Perineural dexmedetomidine is associated with longer durations and faster onset of sensory and motor blockade.
Relativistic spin sum rules and the role of the pivot
Authors: Lorcé Cédric 
Published: May 2021

AbstractSpin sum rules depend on the choice of a pivot, i.e. the point about which the angular momentum is defined, usually identified with the center of the nucleon. The latter is however not unique in a relativistic theory and has led to apparently contradictory results in the literature. Using the recently developed phase-space approach, we compute for the first time the contribution associated with the motion of the center of the nucleon, and we derive a general spin sum rule which reduces to established results after appropriate choices for the pivot and the spin component.
Chiral dynamics and S-wave contributions in $${\bar{B}}^0/D^0 \rightarrow \pi ^{\pm }\eta \ l^{\mp } \nu $$ decays
Authors: Shi Yu-Ji , Meißner Ulf-G. 
Published: May 2021

AbstractIn this work, we analyze the semi-leptonic decays $$\bar{B}^0/D^0 \rightarrow (a_0(980)^{\pm }\rightarrow \pi ^{\pm }\eta ) l^{\mp } \nu $$

B

¯

0

/

D
0

→

(

a
0

(
980
)

±

→

π
±

η
)

l
∓

ν

within light-cone sum rules. The two and three-body light-cone distribution amplitudes (LCDAs) of the B meson and the only available two-body LCDA of the D meson are used. To include the finite-width effect of the $$a_0(980)$$

a
0

(
980
)

, we use a scalar form factor to describe the final-state interaction between the $$\pi \eta $$

π
η

mesons, which was previously calculated within unitarized Chiral Perturbation Theory. The result for the decay branching fraction of the $$D^0$$

D
0

decay is in good agreement with that measured by the BESIII Collaboration, while the branching fraction of the $${\bar{B}}^0$$

B

¯

0

decay can be tested in future experiments.
Seismic characterization of carbonate platforms and reservoirs: an introduction and review
Authors: Hendry James , Burgess Peter , Hunt David , Janson Xavier , Zampetti Valentina 
Published: May 2021

Abstract
Improved seismic data quality in the last 10–15 years, innovative use of seismic attribute combinations, extraction of geomorphological data and new quantitative techniques have significantly enhanced understanding of ancient carbonate platforms and processes. 3D data have become a fundamental toolkit for mapping carbonate depositional and diagenetic facies, and associated flow units and barriers, giving a unique perspective on how their relationships changed through time in response to tectonic, oceanographic and climatic forcing. Sophisticated predictions of lithology and porosity are being made from seismic data in reservoirs with good borehole log and core calibration for detailed integration with structural, palaeoenvironmental and sequence stratigraphic interpretations. Geologists can now characterize entire carbonate platform systems and their large-scale evolution in time and space, including systems with few outcrop analogues such as the Lower Cretaceous Central Atlantic ‘pre-salt’ carbonates. The papers introduced in this review illustrate opportunities, workflows and potential pitfalls of modern carbonate seismic interpretation. They demonstrate advances in knowledge of carbonate systems achieved when geologists and geophysicists collaborate and innovate to maximize the value of seismic data from acquisition, through processing to interpretation. Future trends and developments, including machine learning and the significance of the energy transition, are briefly discussed.
Improving the Quality of FPGA RO-PUF by Principal Component Analysis (PCA)
Authors: A. Asha K. , Hsu Li En , Patyal Abhishek , Chen Hung-Ming 
Published: May 2021

Ring Oscillator Physical Unclonable Functions (RO-PUFs) exploit the inherent manufacturing process variations, such as systematic and stochastic variations, to generate secret PUF responses that are unique to the device. Stochastic variations are random, while systematic variation exhibits a strong spatial correlation. Therefore, systematic process variation reduces the randomness of the PUF response. This lowers the ability of a PUF response to uniquely identify and authenticate individual devices. Further, the impact of systematic variation is paramount when the two ROs in comparison are placed far apart. Comparing the ROs that are close to each other does improve the randomness, but the responses generated are unreliable and limiting the possible Challenge-Response Pairs (CRPs).
In this article, we are proposing a method to reduce the impact of systematic process variation on the RO oscillation frequencies by using Principal Component Analysis (PCA). Principal Components (PCs) model the directions of systematic and stochastic variation present on a device. By projecting the oscillation frequencies in the direction of stochastic variation, the impact of systematic variation can be reduced. Our proposed method neither restricts the placement of ROs to close groups nor limits the possible CRPs. The method is evaluated on a large population of 218 Xilinx Artix-7 FPGAs. To evaluate the efficiency of the proposed method, we purposely paired the ROs that are placed far apart on the FPGA fabric. Results obtained prove the ability of the proposed method in removing the impact of systematic variation on the oscillation frequencies and thereby producing truly random responses.
Therapeutic Effects of Traditional Chinese Exercises on Musculoskeletal Pain: A Systematic Review and Meta-Analysis
Authors: Li Zhenrui , Zhuang Jie , Zhang Shiwen , He Qingyi , Zhao Rui , Alima Tursen , Fang Lei 
Published: May 2021

Background. The number of patients with musculoskeletal pain, which seriously affects people’s quality of life, has increased. Traditional Chinese exercises are accepted and practiced to strengthen the body. Objective. This study aims to explore the efficacy of traditional Chinese exercises for the treatment of musculoskeletal pain. Methods. A comprehensive search of randomized controlled trials (RCTs) related to traditional Chinese exercises on patients with musculoskeletal pain was completed using PubMed, SinoMed, CNKI, VIP, and Wanfang Med Online databases. All RCTs published until February 2021 were considered. Two researchers independently screened the literature according to the predesigned inclusion and exclusion criteria, and data was extracted and assessed for their risk of bias via the Cochrane collaboration tool. Meta-analysis was performed using RevMan5.2 and Rx64 4.0.2 software. Results. A total of 45 RCT studies with 3178 patients were included. Traditional Chinese exercises were able to effectively alleviate patients with musculoskeletal pain (MD = −1.54, 95% confidence interval (−1.88, −1.19),

P

< 0.01). Among them, the Yi Jin Jing exercise was superior to other exercises, while Wu Qin Xi showed no significant effects. Besides, traditional Chinese exercises had significant positive effects on the dysfunction and stiffness of the waist and knee joints. Traditional Chinese exercises could effectively relieve the clinical symptoms of patients with musculoskeletal pain. Particularly, the Yi Jin Jing exercise presented the most significant positive effect on pain reduction.