bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Rasio Profitabilitas, Free Cash Flow, dan Leverage Terhadap Manajemen Laba
Authors: Jelanti Desi 
Published: February 2021

This study aimed to examined the effect of profitability ratio, free cash flow, and leverage on earnings management (empirical studies on Manufacturing Company listed on Indonesian Stock Exchange 2012-2017). The population in this study is 30 companies food and beverage company with period of 2012 to 2016 .The data used in this study is secondary and technique used was purpose sampling obtained a sample of 25 food and beverage company that met the sample criteria. Data analysis using panel regression model (a combination of time series and cross section) by Eviews 8.0 program. The analtytical method used is a multiple linear analysis method to test the effect of profitability ratios, free cash flow and leverage on earnings management. Best on the results of the research: The Ratio of Profitability obtained by the value of the probability of 0.7395 > 0.05, and the free cash flow was obtained with a value of 0.3156 > 0.05 based on those results then H1 rejected and H0 is accepted then the profitability and free cash has no effect on earning management. while the leverage obtained by the value of 0.0003 < 0.05 then H1 accepted and H0 is rejected have a significant positive effect on earning management. Profitability , free cash flow and leverage obtained by the value of the probability of the 0.000000 < 0.05 have a significant effect on earning management.
Abstrak
Penelitian ini bertujuan untuk menguji pengaruh rasio profitabilitas, free cash flow dan leverage terhadap manajemen laba (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar di Bursa Efek Indonesia Tahun 2012-2016). Populasi dalam penelitian ini sebanyak 30 perusahaan makanan dan minuman dengan periode pengamatan 2012 sampai 2017. Penelitian ini menggunkan data skunder dan teknik sampel yang dipakai yaitu purposive sampling diperoleh sampel 25 perusahaan makanan dan minuman yang memenuhui kriteria sampel. Model yang digunakan dalam penelitian ini adalah regresi panel menggunakan aplikasi Eviews 8. Metode analisis yang digunakan adalah metode analisis linear berganda untuk menguji menguji pengaruh rasio profitabilitas, free cash flow dan leverage terhadap manajemen laba. Berdasarkan hasil yang diteliti: Rasio Profitabilitas didapat dengan nilai probabilitas sebesar 0.7395 > 0.05 , dan Free Cash Flow didapat dengan nilai 0.3156 > 0.05 berdasarkan hasil tersebut maka H1 ditolak dan H0 diterima maka profitabilitas dan free cash flow tidak berpengaruh terhadap Manajemen Laba. Sedangkan Leverage didapat dengan nilai 0.0003 < 0.05 maka H1 ditolak dan H0 diterima sehingga Leverage berpengaruh positif signifikan terhadap manajemen laba. Profitabilitas, free cash flow dan leverage diperoleh dengan nilai probabilitas sebesar 0.000000 < 0.05 maka secara bersama-sama berpengaruh signifikan terhadap Manajemen Laba.
Kata Kunci : Rasio profitabilitas, Free Cash Flow, Leverage, Manajemen Laba
Pengaruh Customer Based Brand Equity dan Kepuasan Konsumen terhadap Loyalitas Konsumen
Authors: Nabila Nuzul Inas , Wulan Mutiasari Nur , Paujiah Sipa 
Published: February 2021

The purpose of this study was to determine the effect of customer based brand equity on loyalty and the effect of customer satisfaction on loyalty case studies at Richesee Factory Indonesia. This research uses quantitative methods and is analyzed using validity and reliability tests, factor analysis, and multiple regression analysis. hypothesis testing using SPSS. The unit of analysis in this study was 100 customers from Richesee Factory. The results showed that the influence of customer based brand equity, satisfaction (x1, x2) in influencing each additional variable y loyalty was 56.9% and the remaining 43.1% was influenced by other factors. The influence of customer based brand equity and satisfaction contributed 56.9 to loyalty to Richesee Factory. The first hypothesis (H1) is accepted, which means that customer-based brand equity has a significant effect on loyalty to Richesee Factory. The second hypothesis is accepted, which means that there is a significant effect of customer satisfaction on loyalty to Richesee Factory. So it can be concluded that customer based brand equity and satisfaction have a positive and significant influence on study loyalty at the Richesee Factory.

Abstrak
Tujuan Penelitian adalah untuk mengetahui pengaruh customer based brand equity (ekuitas merek berbasis pelanggan) kepada loyalitas dan pengaruh kepuasan konsumen terhadap loyalitas studi kasus pada Richesee Factory Indonesia Penelitian ini menggunakan metode kuantitatif selanjutnya dianalisis menggunakan uji validitas dan reliabilitas, analisis faktor, dan analisis regresi berganda, uji hipotesis dengan menggunakan SPSS. Unit analisis pada penelitian ini adalah 100 pelanggan dari Richesee Factory. Hasil Penelitian menunjukkan bahwa pengaruh customer based brand equity, kepuasan (x1, x2) dalam mempengaruhi setiap penambahan variabel y loyalitas adalah 56,9% dan sisanya 43,1% dipengaruhi oleh faktor lain. Pengaruh customer based brand equity (ekuitas merek bebasis pelanggan) dan kepuasan memberikan kontribusi 56,9 terhadap loyalitas pada richesee factory. Hipotesis pertama(H1) penelitian diterima yang artinya ada pengaruh secara signifikan customer based brand equity (ekuitas merek berbasis pelanggan) terhadap loyalitas pada richesee factory, Hipotesis kedua penelitian diterima yang artinya ada pengaruh kepuasan konsumen secara signifikan terhadap loyalitas pada Richesee Factory. Sehingga dapat disimpulkan customer based brand equity dan kepuasan mempunyai pengaruh yang positif dan signifikan terhadap loyalitas studi pada Richesee Factory.

Kata Kunci : Ekuitas Merek Berbasis Pelanggan, Kepuasan, Loyalitas
TINGKAT STRESS MAHASISWA S1 ANGKATAN 2014 DALAM MENGHADAPI PENINGKATAN STRATA PENDIDIKAN DI FAKULTAS KEPERAWATAN UNIVERSITAS PADJADJARAN KAMPUS GARUT
Authors: Nurdiansyah Gian , Yamin Ahmad , Amira Iceu 
Published: February 2021

Stres merupakan keadaan seseorang yang mengakibatkan gangguan terhadap fisik dan psikologis. Tingkat stres yang terjadi diakibatkan karena perpindahan mahasiswa dari program diploma ke program sarjana. Tujuan dilakukan penelitian ini untuk mengidentifikasi tingkat stress mahasiswa dalam menghadapi peningkatan strata Pendidikan di Universitas Padjadjaran mahasiswa angkatan 2014. Rancangan penelitian menggunakan deskriptif kuantitatif. Teknik sampling yang digunakan total populasi Â yaitu 87 orang. Tingkat stress diukur dengan kuesioner PSS 10, yang berskala likert data dikelompokan kedalam 3 kategori yaitu stress ringan (skor 1-14), stress sedang (15-26), stress berat (skor >26). Hasil penelitian ini didapatkan bahwa Stres ringan (2,4%), Stres sedang (76%), dan Stress berat (21,2%). Sedangkan hasil tingkat stres berdasarkan usia <20 stress berat yg paling banyak yaitu 5 orang (5,88%) dan usia >20Â stress sedang paling banyak yaitu 52 orang (61,18%). HasilÂ tingkat stress berdasarkanÂ jenis kelamin laki laki terbanyak pada kategori stress sedang (22,35%) dan jenis kelamin perempuan terbanyak pada kategori stress sedang (54,12%). Hasil tingkat stress berdasarkan IPK 3.0-3.5 terbanyak pada katagori stress sedang (65,88%). Kesimpulan dari penelitian ini yang paling dominan adalah stress sedang. Hal ini diakibatkan oleh beban SKS, tugas akhir, dan system block. Bisa lakukan evaluasi dan diberikan pelayanan konseling, dan bimbingan dengan dosen pembimbing untuk mengatasi masalah yang dialami mahasiswa sehingga tidak tidak terjadi stress.
PENGARUH COGNITIVE BEHAVIOR THERAPY (CBT) PADA PENINGKATAN HARGA DIRI REMAJA: LITERATURE REVIEW
Authors: Juniarni Lia , Hadiyani Wini , Marlina Nina , Nurrandi Sandra R. , Anggita Tri Desi 
Published: February 2021

Latar belakang: Studi literature review ini dilatar belakangi oleh masalah psikologis yang sering terjadi pada remaja yaitu harga diri rendah. Harga diri meningkat seiring bertambahnya usia dan paling terancam selama masa remaja. Bentuk penghargaan, penerimaan serta pengakuan membuat seseorang berharga dan diakui kehadirannya oleh lingkungan. Implikasi dari harga diri rendah, akan muncul masalah hubungan interpersonal, masalah dalam sekolah dan pekerjaan, ketergantungan zat, depresi atau gangguan mental lainnya. Tujuan: Literature ini ditujukan untuk menganalisis secara teoritik pengaruh Cognitive Behavior Therapy (CBT) terhadap peningkatan harga diri pada remaja. Metode: Metode kajian literatur dilakukan terhadap lima artikel yang diperoleh dari sejumlah dua database Google Scholar dan PUBMED. Kata kunci untuk pencarian artikel adalah â€œCognitive Behavior Therapy (CBT)â€, â€harga diri rendahâ€, â€œself esteemâ€,â€œtreatmentâ€,â€œremajaâ€,â€Teenagerâ€ or â€Adolecentâ€. Kriteria artikel yang digunakan berbahasa Inggris dan Indonesia, diterbitkanÂ dariÂ tahunÂ 2016 sampai 2018. Hasil : tinjauan ini menunjukkan nilai yang signifikan yaitu dari ketiga artikel menujukan nilai (p< 0.05) yang artinya adanya pengaruh dari terapi kognitif atau cognitive behavior therapy (CBT) terhadap peningkatan harga diri pada remaja. Kesimpulan: terapi kognitif atau cognitive behavior therapy (CBT) merupakan terapi yang diyakini dapat meningkatkan harga diri rendah pada remaja sehingga diharapkan tenaga kesehatan dapat menerapkan terapi kognitif untuk mengurangi tingkat harga diri rendah pada remaja.
STUDI LITERATUR : FAKTOR â€“ FAKTOR YANG BERHUBUNGAN DENGAN HARGA DIRI RENDAH PADA REMAJA
Authors: Widianti Efri , Ramadanti Lia , Karwati Karwati , Kirana K Chandra , Mumtazhas Anjani , Ardianti Aprilia Aulia , Ati Nimas Safitri , Handayani Nurhalimah Tri , Hasanah Hanifah 
Published: February 2021

Harga diri rendah yang terjadi pada remaja dikarenakan secara psikologis konsep diri remaja belum matang dalam berinteraksi dan bergaul. Harga diri rendah dapat mempengaruhi kemampuan remaja untuk bersosialisasi dengan teman yang lain. Dari total kasus harga diri rendah yang terjadi 3 tahun terakhir (2016 - 2018) adalah 57 dengan persentase 99,98%. Tujuan dari penelitian ini adalah untuk mengetahui adanya hubungan antara penampilan fisik dengan terjadinya harga diri rendah situasional pada remaja. Metode yang digunakan adalah pendekatan narrative review. Database utama yang digunakan untuk pencarian literatur adalah PubMed menggunakan kata kunci dengan teknik bolean dalam bahasa Inggris yang disusun menjadi satu kalimat pencarian yaitu â€œTeenagerâ€ OR â€œAdolescentâ€ AND â€œEffectâ€ OR â€œImpactâ€ OR â€œInfluenceâ€ AND â€œbody imageâ€ AND â€œlow self esteemâ€ OR â€œlow situasional self esteemâ€. Â Terdapat 5 artikel yang digunakan, 2 artikel membahas terkait dampak atau hubungan peningkatan berat badan dengan low self esteem, 2 artikel membahas terkait dampak dari perubahan warna kulit terhadap low self esteem baik itu dari jerawat maupun acanthosis nigricans dan 1 artikel membahas terkait hubungan ketidakpuasan tubuh dan harga diri pada remaja. Dari 5 jurnal penelitian yang telah kami pilih, penelitian-penelitian tersebut dilakukan di Spanyol, Turki, America, Nigeria, dan US. Kesimpulan : Terdapat hubungan antara penampilan fisik dengan terjadinya harga diri rendah situasional pada remaja, diantaranya hubungan jerawat hiperpigmentasi dengan harga diri rendah yang berhubungan dengan wajah atau area lain yang tidak tertutup oleh pakaian berpengaruh langsung terhadap tingkat keparahan jerawat dan hubungan kelebihan berat badan dengan harga diri rendah yang berpengaruh terhadap perlakuan yang mereka terima dari teman sebayanya seperti komentar negatif, viktimisasi dan perundungan.
BOW-GBDT: A GBDT Classifier Combining With Artificial Neural Network for Identifying GPCR–Drug Interaction Based on Wordbook Learning From Sequences
Authors: Qiu Wangren , Lv Zhe , Hong Yaoqiu , Jia Jianhua , Xiao Xuan 
Published: February 2021

Background: As a class of membrane protein receptors, G protein-coupled receptors (GPCRs) are very important for cells to complete normal life function and have been proven to be a major drug target for widespread clinical application. Hence, it is of great significance to find GPCR targets that interact with drugs in the process of drug development. However, identifying the interaction of the GPCR–drug pairs by experimental methods is very expensive and time-consuming on a large scale. As more and more database about GPCR–drug pairs are opened, it is viable to develop machine learning models to accurately predict whether there is an interaction existing in a GPCR–drug pair.Methods: In this paper, the proposed model aims to improve the accuracy of predicting the interactions of GPCR–drug pairs. For GPCRs, the work extracts protein sequence features based on a novel bag-of-words (BOW) model improved with weighted Silhouette Coefficient and has been confirmed that it can extract more pattern information and limit the dimension of feature. For drug molecules, discrete wavelet transform (DWT) is used to extract features from the original molecular fingerprints. Subsequently, the above-mentioned two types of features are contacted, and SMOTE algorithm is selected to balance the training dataset. Then, artificial neural network is used to extract features further. Finally, a gradient boosting decision tree (GBDT) model is trained with the selected features. In this paper, the proposed model is named as BOW-GBDT.Results: D92M and Check390 are selected for testing BOW-GBDT. D92M is used for a cross-validation dataset which contains 635 interactive GPCR–drug pairs and 1,225 non-interactive pairs. Check390 is used for an independent test dataset which consists of 130 interactive GPCR–drug pairs and 260 non-interactive GPCR–drug pairs, and each element in Check390 cannot be found in D92M. According to the results, the proposed model has a better performance in generation ability compared with the existing machine learning models.Conclusion: The proposed predictor improves the accuracy of the interactions of GPCR–drug pairs. In order to facilitate more researchers to use the BOW-GBDT, the predictor has been settled into a brand-new server, which is available at http://www.jci-bioinfo.cn/bowgbdt.
A Novel Cr2O3/MnO2-x Electrode for Lithium-Oxygen Batteries with Low Charge Voltage and High Energy Efficiency
Authors: Wei Zhaohuan , Zhang Zhiyuan , Ren Yaqi , Zhao Hong 
Published: February 2021

A high energy efficiency, low charging voltage cathode is of great significance for the development of non-aqueous lithium-oxygen batteries. Non-stoichiometric manganese dioxide (MnO2-x) and chromium trioxide (Cr2O3) are known to have good catalytic activities for the discharging and charging processes, respectively. In this work, we prepared a cathode based on Cr2O3 decorated MnO2-x nanosheets via a simple anodic electrodeposition-electrostatic adsorption-calcination process. This combined fabrication process allowed the simultaneous introduction of abundant oxygen vacancies and trivalent manganese into the MnO2-x nanosheets, with a uniform load of a small amount of Cr2O3 on the surface of the MnO2-x nanosheets. Therefore, the Cr2O3/MnO2-x electrode exhibited a high catalytic effect for both discharging and charging, while providing high energy efficiency and low charge voltage. Experimental results show that the as-prepared Cr2O3/MnO2-x cathode could provide a specific capacity of 6,779 mA·h·g−1 with a terminal charge voltage of 3.84 V, and energy efficiency of 78%, at a current density of 200 mA·g−1. The Cr2O3/MnO2-x electrode also showed good rate capability and cycle stability. All the results suggest that the as-prepared Cr2O3/MnO2-x nanosheet electrode has great prospects in non-aqueous lithium-oxygen batteries.
Vegetation Restoration Alters Fungal Community Composition and Functional Groups in a Desert Ecosystem
Authors: Zhang Ying , Cao Hongyu , Zhao Peishan , Wei Xiaoshuai , Ding Guodong , Gao Guanglei , Shi Mingchang 
Published: February 2021

Revegetation is regarded as an effective means to improve the ecological environment in deserts and profoundly influences the potential ecological functions of the soil fungal community. Therefore, Illumina high-throughput sequencing was performed to characterize the soil fungal diversity and community composition at two soil depths (0–10 cm and 10–20 cm) with four revegetation durations (natural grassland, half-mature, nearly mature, and mature Pinus. sylvestris var. mongolica plantations) in the Mu Us Sandy Land, China. The effects of soil properties on soil fungal communities were also examined to reveal the connection between fungal function and soil environment. The results indicated that 1) soil nutrient content and enzyme activity showed significant differences through the restoration durations, 2) there was no significant effect of soil depth on soil fungal diversity, while the Shannon diversity index of all fungal communities was significantly different among different revegetation durations, 3) compared with grassland, ectomycorrhizal fungi (notably, Inocybe, Tuber, and Calostoma) were abundant in plantations. The endophyte fungus Mortierella was among the top 10 genera in all soil samples and arbuscular mycorrhizal fungus Diversispora was the indicator genus of the grassland, and 4) catalase and total nitrogen were the main factors affecting fungal community composition and were closely related to saprotrophs and pathotrophs, respectively. This new information indicates the variation of soil fungal communities along revegetation durations and highlights the interaction between fungal functions and desert ecosystems.
Successful HCV Therapy Reduces Liver Disease Severity and Inflammation Biomarkers in HIV/HCV-Coinfected Patients With Advanced Cirrhosis: A Cohort Study
Authors: Medrano Luz Maria , Berenguer Juan , Salgüero Sergio , González-García Juan , Díez Cristina , Hontañón Víctor , Garcia-Broncano Pilar , Ibañez-Samaniego Luis , Bellón José M. , Jiménez-Sousa María Angeles , Resino Salvador 
Published: February 2021

Background: Eradication of hepatitis C virus (HCV) promotes an improvement in liver disease and the deactivation of the immune system. Here, we aimed to evaluate the changes in liver disease scores and plasma biomarkers following HCV clearance with direct-acting antivirals (DAAs) in HIV-infected patients with advanced HCV-related cirrhosis.Methods: We performed an observational study of 50 patients with advanced cirrhosis who received DAAs therapy. Variables were assessed at baseline and 48 weeks after HCV treatment completion. Epidemiological and clinical data were collected through an online form. Liver stiffness measurement (LSM), hepatic venous pressure gradient (HVPG), and Child-Pugh-Turcotte (CTP) were evaluated by physicians. Plasma biomarkers were measured by multiplex immunoassay.Results: We found significant decreases in severity scores of liver disease [LSM (q-value &lt; 0.001), HVPG (q-value = 0.011), and CTP (q-value = 0.045)] and plasma biomarkers [LBP (q-value &lt; 0.001), IP-10 (q-value &lt; 0.001), IL-8 (q-value &lt; 0.001), IL-18 (q-value &lt; 0.001), IL-1RA (q-value = 0.013), OPG (q-value &lt; 0.001), sVCAM-1 (q-value &lt; 0.001), sICAM-1 (q-value &lt; 0.001), PAI-1 (q-value = 0.001), and VEGF-A (q-value = 0.006)]. We also found a significant direct association between the change in LSM values and the change in values of LBP (q-value &lt; 0.001), IP-10 (q-value &lt; 0.001), MCP-1 (q-value = 0.008), IL-8 (q-value &lt; 0.001), IL-18 (q-value &lt; 0.001), OPG (q-value = 0.004), sVCAM-1 (q-value &lt; 0.001), sICAM-1 (q-value &lt; 0.001), and PAI-1 (q-value = 0.002). For CTP values, we found significant positive associations with IP-10 (q-value = 0.010), IL-6 (q-value = 0.010), IL-1RA (q-value = 0.033), and sICAM-1 (q-value = 0.010).Conclusion: The HCV eradication with all-oral DAAs in HIV/HCV-coinfected patients with advanced cirrhosis promoted an improvement in the severity of advanced cirrhosis and plasma biomarkers (inflammation, coagulopathy, and angiogenesis). The decrease in plasma biomarkers was mainly related to the reduction in LSM values.
Comprehensive Succinylome Profiling Reveals the Pivotal Role of Lysine Succinylation in Energy Metabolism and Quorum Sensing of Staphylococcus epidermidis
Authors: Zhao Yiping , Han Yang , Sun Yuzhe , Wei Zhendong , Chen Jialong , Niu Xueli , An Qian , Zhang Li , Qi Ruiqun , Gao Xinghua 
Published: February 2021

BackgroundLysine succinylation is a newly identified posttranslational modification (PTM), which exists widely from prokaryotes to eukaryotes and participates in various cellular processes, especially in the metabolic processes. Staphylococcus epidermidis is a commensal bacterium in the skin, which attracts more attention as a pathogen, especially in immunocompromised patients and neonates by attaching to medical devices and forming biofilms. However, the significance of lysine succinylation in S. epidermidis proteins has not been investigated.ObjectivesThe purpose of this study was to investigate the physiological and pathological processes of S. epidermidis at the level of PTM. Moreover, by analyzing previous succinylome datasets in various organisms, we tried to provide an in-depth understanding of lysine succinylation.MethodsUsing antibody affinity enrichment followed by LC-MS/MS analysis, we examined the succinylome of S. epidermidis (ATCC 12228). Then, bioinformatics analysis was performed, including Gene Ontology (GO), KEGG enrichment, motif characterization, secondary structure, protein–protein interaction, and BLAST analysis.ResultsA total of 1557 succinylated lysine sites in 649 proteins were identified in S. epidermidis (ATCC 12228). Among these succinylation proteins, GO annotation showed that proteins related to metabolic processes accounted for the most. KEGG pathway characterization indicated that proteins associated with the glycolysis/gluconeogenesis and citrate cycle (TCA cycle) pathway were more likely to be succinylated. Moreover, 13 conserved motifs were identified. The specific motif KsuD was conserved in model prokaryotes and eukaryotes. Succinylated proteins with this motif were highly enriched in the glycolysis/gluconeogenesis pathway. One succinylation site (K144) was identified in S-ribosylhomocysteine lyase, a key enzyme in the quorum sensing system, indicating the regulatory role succinylation may play in bacterial processes. Furthermore, 15 succinyltransferases and 18 desuccinylases (erasers) were predicted in S. epidermidis by BLAST analysis.ConclusionWe performed the first comprehensive profile of succinylation in S. epidermidis and illustrated the significant role succinylation may play in energy metabolism, QS system, and other bacterial behaviors. This study may be a fundamental basis to investigate the underlying mechanisms of colonization, virulence, and infection of S. epidermidis, as well as provide a new insight into regulatory effects succinylation may lay on metabolic processes (Data are available via ProteomeXchange with identifier PXD022866).