bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the Meaning of the “Sharing Economy” Shared Among Us? Comparing the Perspectives of Japanese and Swedish Policymakers and Politicians
Authors: Fors Per , Inutsuka Yu , Majima Takashi , Orito Yohko 
Published: February 2021

AbstractIn another paper in this special issue, we explored how the sharing economy was understood and promoted by researchers in Japan and Sweden, respectively. In this second paper, which is based on two separate archival studies, we proceed by focusing on how the concept is used and understood in the political sphere by politicians and policymakers in the two contexts. On a general level, the sharing economy is understood as an economic model based on the acquisition, provision, and sharing of goods and services, facilitated by digital platforms. This study concludes that within the political spheres in Japan and Sweden there are, however, many different more specific understandings of and assumptions related to the concept. For example, the sharing economy is primarily promoted as a tool for economic revitalization and growth in Japan, while in Sweden its environmental benefits are emphasized. In Japan, there seems to be more consensus around what the sharing economy is, what its main effects are, and how it should be promoted. In Sweden, political parties instead advance different understandings of, and assumptions related to, the sharing economy to advance their political agendas. While the concept has been successfully translated in Japan by powerful political institutions and actors, we argue that the concept remains open to many different interpretations in Sweden.
Treatment of Partial Posterior Cruciate Ligament Injuries with Platelet-Rich Plasma in Growth Factors (PRGF) Intraligamentous Infiltration and a Specific Knee Brace
Authors: Barastegui David , Alentorn-Geli Eduard , Gotecha Dhaval , Rius Marta , Navarro Jordi , Cuscó Xavier , Seijas Roberto , Cugat Ramón 
Published: February 2021

AbstractPosterior cruciate ligament (PCL) injuries are not as common as other knee ligament injuries, but may present a challenging scenario for even skilled knee surgeons. Complete PCL tears are typically encountered in the setting of multiligament knee injuries and require surgical treatment. Isolated complete PCL injuries are uncommon and the best treatment is debated, and likely depends on the degree of symptoms and objective instability. However, many PCL injuries will be partial tears (grade I or II). The purpose of this chapter is to describe our treatment of choice for partial PCL injuries through a conservative approach.
Level of evidence Level IV.
Vertical Strabismus and Positive Bielschowsky Head-Tilt Test: Atypical Presentation of a Maxillary Mucocele
Authors: André Correia Filipe , Filipe Antunes de Almeida Gustavo , Fernandes Pereira Bruxelas Carolina , Batista Brissos de Sousa Escada Pedro Alberto 
Published: February 2021

AbstractTest of skew has become a cornerstone in the approach of a patient with vestibular symptoms but a detected vertical misalignment may be caused by an oculomotor disturbance and not a skew deviation. We report the case of an elderly patient with a 1-month history of dizziness and visual disturbance that revealed on bedside examination a spontaneous left head-tilt and a pathologic alternate cover test, with right eye hypertropia and excyclotorsion, worse with right head-tilt. Dizziness was assumed to have a visual origin with unrecognized binocular diplopia, caused by an acquired right eye superior oblique muscle palsy. However, imaging revealed a right maxillary mucocele that eroded the orbit floor into the orbit. The change of the intraorbital component of the maxillary fluid-filled mass with head-tilt through a dehiscent orbital floor may explain the findings of vertical strabismus and positive Bielschowsky head-tilt test in this case. Endoscopic treatment improved symptoms and findings.
Leaf‐cutting ant abundance and distribution under different agricultural practices in grassland biome
Authors: Ribero Martín N. , Pinto Carolina , Bellocq María I. , Filloy Julieta 
Published: February 2021

AbstractLeaf‐cutting ants (LCA) frequently show positive associations with human disturbance in forest biome, explained by habitat opening and increase of pioneer vegetation. However, little is known about LCA response in grassland biome. Agriculture and commercial forestry typically introduce closed habitats and displace pioneer vegetation when occurring in grasslands. The aim of this study was to assess the response of LCA to different land use types developed in a grassland biome.
Semi‐natural grassland remnants, soybean crops, cattle pastures and young and mature eucalypt plantations were sampled in Entre Ríos, Argentina. LCA nest abundance and occurrence of workers was obtained by hand sampling and baited pitfall traps.
LCA nest abundance significantly decreased in most land use types when compared with the grassland sites. All habitat types were characterized by the presence of different LCA species, which showed different associations with temperature, vegetation and soil structure.
Our results suggest that LCA response to human disturbance depends on the biome where it occurs; contrary to what was observed in forests, the LCA assemblage was negatively associated to human disturbance in grasslands. The response of the whole assemblage masked different responses of LCA species, possibly indicating differences in their ecological niche.
Impact of the menstrual cycle and ethinyl estradiol/etonogestrel contraceptive vaginal ring on granulysin and other mucosal immune mediators
Authors: Hughes Sean M. , Pandey Urvashi , Johnston Christine , Marrazzo Jeanne , Hladik Florian , Micks Elizabeth 
Published: February 2021

AbstractProblemChanges in sex hormones during the menstrual cycle and contraceptive vaginal ring (CVR) use influence immunity within the female genital tract, but the magnitude of these effects and their anatomical location are unclear.Method of StudyIn a prospective study, 29 women were assessed at three‐time points: follicular phase, luteal phase, and one month after initiation of the ethinyl estradiol/etonogestrel CVR (NuvaRing®, Merck). We performed microarrays on endocervical cytobrushes and measured immune mediators in cervicovaginal fluid, adjusting for bacterial vaginosis and the presence of blood. We compared these results to public gene expression data from the fallopian tubes, endometrium, endo‐ and ectocervix, and vagina.ResultsImmune‐related gene expression in the endocervix and immune mediators in cervicovaginal fluid increased during CVR use versus both menstrual phases, and in the follicular versus luteal phase. The antimicrobial protein granulysin was high during CVR use, intermediate in the follicular phase, and nearly absent from the luteal phase. Re‐analysis of public gene expression data confirmed increased immune‐related gene expression in the endocervix during the follicular phase. However, in the fallopian tube, endometrium, and vagina, the follicular phase showed immunosuppression.ConclusionsImmune‐related genes in the cervicovaginal tract were highest during CVR use, intermediate in the follicular phase, and lowest in the luteal phase. Granulysin is a potential biomarker of menstrual phase: Frequently detected in follicular samples, but rare in luteal. Lastly, immunological differences between the follicular and luteal phases vary throughout the female genital tract.
Innovation, trade and multi‐product firms
Authors: Montinari Letizia , Riccaboni Massimo , Schiavo Stefano 
Published: February 2021

AbstractThis paper contributes to the literature on the relationship between innovation and exports by developing a model that emphasizes the role of product innovation in explaining heterogeneity in export behaviour both across and within firms. The dynamic model assumes that firms invest to maintain and increase the portfolio of products they sell: innovation is a stochastic process whereby the probability to capture new business opportunities is a function of the number of goods already sold. Crucially, the model assumes two independent mechanisms to drive the extensive and the intensive margins of a firm's export. The resulting lack of (built‐in) correlation between the two margins is well reflected in the data and represents the main contribution of our theoretical framework. The model is consistent with several other empirical regularities that characterize multi‐product firms, such as the heavy tail in the distribution of the number of products exported by each firm, the strict hierarchy in the sales of products across markets, the substantial degree of product churning and the highly skewed distributions of export sales.
Pharmacogenomics guided versus standard antidepressant treatment in a community pharmacy setting: A randomized controlled trial
Authors: Papastergiou John , Quilty Lena C. , Li Wilson , Thiruchselvam Thulasi , Jain Esha , Gove Peter , Mandlsohn Leilany , van den Bemt Bart , Pojskic Nedzad 
Published: February 2021

AbstractThe literature on pharmacogenomics as a tool to support antidepressant precision is burgeoning. Recently, a more active role has been argued for pharmacists in pharmacogenomic testing, with both pharmacists and family physicians perceiving pharmacist‐led testing as a valuable method by which to scale this innovation for depression treatment. In this prospective, single‐blind randomized controlled design, we evaluated the impact of pharmacogenomics guided versus standard antidepressant treatment of depression and anxiety, implemented in three large community pharmacies. Participants were 213 outpatients diagnosed with major depressive disorder and/or generalized anxiety disorder, randomized to receive pharmacogenomics guided (n = 105) or standard antidepressant treatment (n = 108); participants were blinded to the study. Patient reported outcomes of depression, anxiety, disability, and treatment satisfaction were assessed at months 0, 1, 3, and 6. Hypotheses were investigated using mixed effect models on the full data. All clinical outcomes improved significantly. The primary outcome (depression) and two secondary outcomes (generalized anxiety and disability) exhibited significant time by group interactions indicating that they improved for participants who received pharmacogenomics guided treatment more so than they did for participants who received standard treatment. Treatment satisfaction improved similarly for both groups. Results contribute to a growing body of work evaluating the impact of pharmacogenomics testing to inform antidepressant medication treatment for depression and anxiety, and provides important initial evidence for the role of pharmacists in care delivery. Pharmacogenomic testing may be a valuable tool to allow pharmacists to more effectively collaborate in facilitating clinical treatment decisions. ClinicalTrials.gov registration: (NCT03591224).
INCORPORATION OF ACALYPHA INDICA EXTRACT IN POLYVINYL ALCOHOL HYDROGELS: PHYSICO-CHEMICAL, ANTIBACTERIAL AND CELL COMPATIBILITY ANALYSES
Authors: Jumat Mohamad Amin , Zahidin Nor Syahiran , Zaini Mohd Amirul Aizat , Fadzil Nurul Afiqah , Nur Hadi , Saidin Syafiqah 
Published: February 2021

Acalypha indica (A. indica) possesses antibacterial properties and has capability to accelerate wound healing due to its active therapeutic compounds of flavonoid and alkaloid. The incorporation of A. indica extracts in polymer hydrogels is useful for wound treatment, despite the advancement in synthetic medicines and drugs. In this study, polyvinyl alcohol (PVA) hydrogels with different concentrations of A. indica extract (0.5, 1.0, 1.5 and 2.0 mg) were fabricated. The ATR-FTIR spectra testified the presence of A. indica in the hydrogels. More enormous spotted agglomerations were visualized on the higher concentrations of A. indica hydrogels. The A. indica hydrogels became less moisture, more hydrophobic and has low water uptake ability compared to the control hydrogel (without A. indica). The antibacterial activities of the hydrogels against Escherichia coli and Staphylococcus aureus were acted in a dose-dependent manner where higher inhibition zones and higher bacterial retardations were recorded on the hydrogels with higher concentrations of A. indica. The incorporation of A. indica (1.0 - 1.5 mg/mL) has also induced cell viability, cell migration, and proliferation of the human skin fibroblasts. Therefore, optimization of the A. indica hydrogels is crucial in accommodating the bi-functional properties of antibacterial and biocompatibility for wound treatment.
BACTERIAL DESULFURIZATION OF DIBENZOTHIOPHENE BY PSEUDOMONAS SP. STRAIN KWN5 IMMOBILIZED IN ALGINATE BEADS
Authors: Gunam Ida Bagus Wayan , Sitepu Ardiansyah , Antara Nyoman Semadi , Triani I Gusti Ayu Lani , Arnata I Wayan , Setiyo Yohanes 
Published: February 2021

Biodelfurization of petroleum has emerged as a potential alternative to the hydrodesulfurization and oxidative desulfurization processes. However, the main obstacle in its commercial application is the efficiency and practicality of using bacterial cells. Pseudomonas sp. strain KWN5 was tested for the ability to use dibenzothiophene (DBT) in n-tetradecane as the sole sulfur source with two phase oil-water system. The biodesulfurization ability of strain KWN5 was evaluated by immobilized cells with dibenzothiophene as substrates. The cells immobilized by entrapping them with sodium alginate (SA) had high DBT biodesulfurization activity and could degrade 100 mg DBT/L in n-tetradecane of 46.76–100%, depended on concentrations of sodium alginate and cells within 24 h at 37oC with shaking at 160 rpm. The combination of SA concentration of 3% (w/v) with bacterial cells OD660 40 (25.52 mg DCW/mL) has an optimal biodesulfurization activity on 100 mg DBT/L in n-tetradecane, which is equal to 71.85% biodesulfurization. The immobilized cells of Pseudomonas sp. strain KWN5 in alginate beads were more efficient for the degradation of DBT and can be reused for five cycles (220 h) without any loss in their activity. The results of this study clearly show the role of the effects of cell immobilization in increasing the process of biodesulfurization.
TAGUCHI ORTHOGONAL DESIGN FOR OPTIMIZING A UNIFIED TERNARY PROCESS TO VALORIZE OIL PALM LEAVES FOR NANOCELLULOSE ISOLATION
Authors: Shunmugam Shamini , Teo Hwee Li , Elias Nursyafiqah , Abdul Wahab Roswanira 
Published: February 2021

Oil palm leaves (OPL), as the major component of oil palm biomass, was capitalized for the isolation of nanocellulose (NC) by unified ternary acoustic, chemical- and enzyme-assisted techniques. This study aimed to statistically optimize the extraction parameters via the Taguchi Design for sonication time, duration of enzymatic hydrolysis, the concentration of acid, and the duration of acid hydrolysis, for the highest crystallinity of the isolated NC. The optimum condition required a sonication duration of 20 min, 1 h of acid hydrolysis in 6 M of H2SO4 and 1 h of enzymatic hydrolysis that resulted in the production of NC with a maximum 68.2% crystallinity index, based on X-ray diffraction (XRD) data. Duration of sonication time and acid hydrolysis was crucial for improving the crystallinity of isolated NC. The reduced C=O and C=C peaks at 1734 cm-1 and 1536 cm-1, respectively, in the Fourier-transform Infrared (FTIR) spectra of isolated NC, confirmed the removal of appreciable amounts of hemicellulose and lignin components in the OPL fibers. FESEM micrographs revealed the needle-like structures of NC with diameters between 21‒24.8 nm. The NC isolation approach presented here offers a promising avenue to ease the use of harsh acids for biomass pretreatment.
Assessment of central cartilaginous tumor of the appendicular bone: inter-observer and intermodality agreement and comparison of diagnostic performance of CT and MRI
Authors: Lee Seungbo , Yoon Min A 
Published: February 2021

Background Diagnostic performance, inter-observer agreement, and intermodality agreement between computed tomography (CT) and magnetic resonance imaging (MRI) in the depiction of the major distinguishing imaging features of central cartilaginous tumors have not been investigated. Purpose To determine the inter-observer and intermodality agreement of CT and MRI in the evaluation of central cartilaginous tumors of the appendicular bones, and to compare their diagnostic performance. Material and Methods Two independent radiologists retrospectively reviewed preoperative CT and MRI. Inter-observer and intermodality agreement between CT and MRI in the assessment of distinguishing imaging features, including lesion size, deep endosteal scalloping, cortical expansion, cortical disruption, pathologic fracture, soft tissue extension, and peritumoral edema, were evaluated. The agreement with histopathology and the accuracy of the radiologic diagnoses made with CT and MRI were also analyzed. Results A total of 72 patients were included. CT and MRI showed high inter-observer and intermodality agreements with regard to size, deep endosteal scalloping, cortical expansion, cortical disruption, and soft tissue extension (ICC = 0.96–0.99, k = 0.60–0.90). However, for the evaluation of pathologic fracture, MRI showed only moderate inter-observer agreement (k = 0.47). Peritumoral edema showed only fair intermodality agreement (k = 0.28–0.33) and moderate inter-observer agreement (k = 0.46) on CT. Both CT and MRI showed excellent diagnostic performance, with high agreement with the histopathology (k = 0.89 and 0.87, respectively) and high accuracy (91.7% for both CT and MRI). Conclusion CT and MRI showed high inter-observer and intermodality agreement in the assessment of several distinguishing imaging features of central cartilaginous tumors of the appendicular bones and demonstrated comparable diagnostic performance.
Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis
Authors: Yuen Erick , Fried Jacob , Nguyen Shaun A , Rizk Habib G , Ward Celine , Meyer Ted A 
Published: February 2021

Objective To determine the prevalence of hearing loss (HL) in patients with systemic lupus erythematosus (SLE), describe frequency-specific hearing threshold changes in this patient population as compared to age-matched control, and compare the clinical and serological profiles of patients with SLE with and without HL. Methods A systematic review querying four databases (PubMed, Web of Science, Scopus, and Cochrane) was performed. Meta-analysis of available data was performed to determine the overall prevalence and odds ratio (OR) of HL, and compare mean differences in frequency-specific hearing thresholds between patients with SLE and control. Additionally, meta-analysis of proportions allowed for comparison of disease features present in patients with SLE with and without sensorineural HL. Results This review included 17 studies reporting on 1326 patients (635 with SLE and 691 control). The pooled prevalence of HL in patients with SLE was 27%. In comparison to control, patients with SLE had a significantly higher odds of HL (OR 14.6, 95% CI: 8.5 to 25.0). Mean air-conduction hearing thresholds in patients with SLE were significantly elevated relative to control at 125 and 250 Hz. Mean bone-conduction hearing thresholds were significantly elevated in patients with SLE across all measured frequencies except at 3000 and 6000 Hz compared to control. Disease features did not significantly differ between patients with SLE with and without HL. Conclusion Compared to age-matched control, patients with SLE have increased odds of HL, which primarily manifests at low frequencies. Therefore, this patient population requires greater audiologic attention.
Use of a Head-Tilting Baseplate During Tomotherapy to Shorten the Irradiation Time and Protect the Hippocampus and Lens in Hippocampal Sparing-Whole Brain Radiotherapy
Authors: Miura Kosei , Kurosaki Hiromasa , Utsumi Nobuko , Sakurai Hideyuki 
Published: February 2021

Purpose: The aim of this study is to comparatively examine the possibility of reducing the exposure dose to organs at risk, such as the hippocampus and lens, and improving the dose distribution of the planned target volume with and without the use of a head-tilting base plate in hippocampal-sparing whole-brain radiotherapy using tomotherapy. Methods: Five paired images of planned head computed tomography without and with tilt were analyzed. The hippocampus and planning target volume were contoured according to the RTOG 0933 contouring atlas protocol. The hippocampal zone to be avoided was delineated using a 5-mm margin. The prescribed radiation dose was 30 Gy in 10 fractions. The absorbed dose to planning target volume dose, absorbed dose to the organ at risk, and irradiation time were evaluated. The paired t-test was used to analyze the differences between hippocampal-sparing whole-brain radiotherapy with head tilts and without head tilts. Results: Hippocampal-sparing whole-brain radiotherapy with tilt was not superior in planning target volume doses using the homogeneity index than that without tilt; however, it showed better values, and for Dmean and D2%, the values were closer to 30 Gy. Regarding the hippocampus, dose reduction with tilt was significantly greater at Dmax, Dmean, and Dmin, whereas regarding the lens, it was significantly greater at Dmax and Dmin. The irradiation time was also predominantly shorter. Conclusion: In our study, a tilted hippocampal-sparing whole-brain radiotherapy reduced the irradiation time by >10%. Therefore, our study indicated that hippocampal-sparing whole-brain radiotherapy with tomotherapy should be performed with a tilt. The head-tilting technique might be useful during hippocampal-sparing whole-brain radiotherapy. This method could decrease the radiation exposure time, while sparing healthy organs, including the hippocampus and lens.