bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female sexual dysfunction in multiple system atrophy: a prospective cohort study
Authors: Raccagni Cecilia , Indelicato Elisabetta , Sidoroff Victoria , Daniaux Martin , Bader Angelika , Toth Bettina , Jelisejevas Lukas A. , Hochleitner Margarethe , Fanciulli Alessandra , Leys Fabian , Eschlboeck Sabine , Kaindlstorfer Christine , Boesch Sylvia , Wenning Gregor K. 
Published: September 2021

Abstract
Purpose
The diagnosis of probable multiple system atrophy relies on the presence of severe cardiovascular or urogenital autonomic failure. Erectile dysfunction is required to fulfil the latter criterion in men, whereas no corresponding item is established for women. In this study, we aimed to investigate sexual dysfunction in women with multiple system atrophy.

Methods
We administered the Female Sexual Function Index questionnaire and interviewed women with multiple system atrophy and age-matched controls regarding the presence of “genital hyposensitivity.”

Results
We recruited 25 women with multiple system atrophy and 42 controls. Female Sexual Function Index scores in sexually active women with multiple system atrophy were significantly lower (multiple system atrophy = 10; 15.4, 95% CI [10.1, 22.1], controls = 37; 26.1 [24.1, 28.1], p = 0.0004). The lowest scores concerned the domains of desire, arousal and lubrication. Genital hyposensitivity was reported by 56% of the patients with multiple system atrophy and 9% controls (p < 0.0001).

Conclusions
Sexual dysfunction is highly prevalent in women with multiple system atrophy. Screening for disturbances in specific sexual domains should be implemented in the clinical evaluation of women with suggestive motor symptoms.
Liquid Chromatography Analysis of Reactive Oxoammonium Cations
Authors: Rohland Philip , Schreyer Kristin , Burges Rene , Fritz Nicole , Hager Martin D. , Schubert Ulrich S. 
Published: September 2021

AbstractThis study presents the first liquid chromatography method for the quantitative and qualitative analysis of highly reactive oxoammonium cations based on a simple derivatization reaction. Rapid 1,2-electrophilic addition reactions with olefins were used to transform these reactive species into analyzable derivates. Three model substances were chosen to represent each of the main application fields of oxoammonium cations and to demonstrate the versatility of the method. The measuring protocol was validated according to the ICH and USP guidelines. The method revealed an excellent linearity (R2 = 0.9980–0.9990) with a low limit of detection (0.16–0.14 mmol L−1) and a low limit of quantification (0.55–0.43 mmol L−1). The protocol was finally used to determine the oxoammonium cations in the presence of their corresponding radical, showing a robustness against impurity concentration of up to approx. 30%.
Rurally rooted cross-border migrant workers from Myanmar, Covid-19, and agrarian movements
Authors: Borras Saturnino M. , Franco Jennifer C. , Ra Doi , Kramer Tom , Kamoon Mi , Phyu Phwe , Ju Khu Khu , Vervest Pietje , Oo Mary , Shell Kyar Yin , Soe Thu Maung , Dau Ze , Phyu Mi , Poine Mi Saryar , Jumper Mi Pakao , Mon Nai Sawor , Oo Khun , Thu Kyaw , Khine Nwet Kay , Naing Tun Tun , Papa Nila , Htwe Lway Htwe , Reang Lway Hlar , Jay Lway Poe , Jai Naw Seng , Xu Yunan , Wang Chunyu , Ye Jingzhong 
Published: September 2021

AbstractThis paper examines the situation of rurally rooted cross-border migrant workers from Myanmar during the Covid-19 pandemic. It looks at the circumstances of the migrants prior to the global health emergency, before exploring possibilities for a post-pandemic future for this stratum of the working people by raising critical questions addressed to agrarian movements. It does this by focusing on the nature and dynamics of the nexus of land and labour in the context of production and social reproduction, a view that in the context of rurally rooted cross-border migrant workers necessarily requires interrelated perspectives on labour, agrarian, and food justice struggles. This requires a rethinking of the role of land, not as a factor in either production or social reproduction, but as a central component in both spheres simultaneously. The question is not ‘whether’ it is necessary and desirable to forge multi-class coalitions and struggles against external capital, while not losing sight of the exploitative relations within rural communities and the household; rather, the question is ‘how’ to achieve this. It will require a messy recursive process, going back and forth between theoretical exploration and practical politics.
Management and Business Ethics in Central and Eastern Europe: Introduction to Special Issue
Authors: Soulsby Anna , Remišová Anna , Steger Thomas 
Published: September 2021

AbstractThis special issue focuses on the developments in ethical standards in the post-communist countries of Central and Eastern Europe (CEE) including the former Soviet Union. Over thirty years have elapsed since the demise of the Soviet Bloc and, despite some common institutional features, the societies have had very different experiences with uneven developments across the region since the collapse of communism. In this special issue, the authors explore business and management ethics situated within the context of the challenges that face these still transforming post-communist societies. The papers cover a range of issues and countries including Albania, Belarus, Bulgaria, Croatia, the Czech Republic, Estonia, Hungary, Kyrgyzstan, Latvia, Lithuania, North Macedonia, Poland, Romania, Russia, Slovakia, Slovenia. Potential further avenues for research are identified in the field of business ethics in post-communist societies.
Models of pancreatic ductal adenocarcinoma
Authors: Dennaoui Rayane , Shrestha Hridaya , Wagner Kay-Uwe 
Published: September 2021

AbstractAlthough pancreatic cancer remains to be a leading cause of cancer-related deaths in many industrialized countries, there have been major advances in research over the past two decades that provided a detailed insight into the molecular and developmental processes that govern the genesis of this highly malignant tumor type. There is a continuous need for the development and analysis of preclinical and genetically engineered pancreatic cancer models to study the biological significance of new molecular targets that are identified using various genome-wide approaches and to better understand the mechanisms by which they contribute to pancreatic cancer onset and progression. Following an introduction into the etiology of pancreatic cancer, the molecular subtypes, and key signaling pathways, this review provides an overview of the broad spectrum of models for pancreatic cancer research. In addition to conventional and patient-derived xenografting, this review highlights major milestones in the development of chemical carcinogen-induced and genetically engineered animal models to study pancreatic cancer. Particular emphasis was placed on selected research findings of ligand-controlled tumor models and current efforts to develop genetically engineered strains to gain insight into the biological functions of genes at defined developmental stages during cancer initiation and metastatic progression.
Demographic modeling informs functional connectivity and management interventions in Graham’s beardtongue
Authors: Jones Matthew R. , Winkler Daniel E. , Massatti Rob 
Published: September 2021

AbstractFunctional connectivity (i.e., the movement of individuals across a landscape) is essential for the maintenance of genetic variation and persistence of rare species. However, illuminating the processes influencing functional connectivity and ultimately translating this knowledge into management practice remains a fundamental challenge. Here, we combine various population structure analyses with pairwise, population-specific demographic modeling to investigate historical functional connectivity in Graham’s beardtongue (Penstemon grahamii), a rare plant narrowly distributed across a dryland region of the western US. While principal component and population structure analyses indicated an isolation-by-distance pattern of differentiation across the species’ range, spatial inferences of effective migration exposed an abrupt shift in population ancestry near the range center. To understand these seemingly conflicting patterns, we tested various models of historical gene flow and found evidence for recent admixture (~ 3400 generations ago) between populations near the range center. This historical perspective reconciles population structure patterns and suggests management efforts should focus on maintaining connectivity between these previously isolated lineages to promote the ongoing transfer of genetic variation. Beyond providing species-specific knowledge to inform management options, our study highlights how understanding demographic history may be critical to guide conservation efforts when interpreting population genetic patterns and inferring functional connectivity.
Unveiling the gravitational universe at μ-Hz frequencies
Authors: Sesana Alberto , Korsakova Natalia , Sedda Manuel Arca , Baibhav Vishal , Barausse Enrico , Barke Simon , Berti Emanuele , Bonetti Matteo , Capelo Pedro R. , Caprini Chiara , Garcia-Bellido Juan , Haiman Zoltan , Jani Karan , Jennrich Oliver , Johansson Peter H. , Khan Fazeel Mahmood , Korol Valeriya , Lamberts Astrid , Lupi Alessandro , Mangiagli Alberto , Mayer Lucio , Nardini Germano , Pacucci Fabio , Petiteau Antoine , Raccanelli Alvise , Rajendran Surjeet , Regan John , Shao Lijing , Spallicci Alessandro , Tamanini Nicola , Volonteri Marta , Warburton Niels , Wong Kaze , Zumalacarregui Miguel 
Published: September 2021

AbstractWe propose a space-based interferometer surveying the gravitational wave (GW) sky in the milli-Hz to μ-Hz frequency range. By the 2040s, the μ-Hz frequency band, bracketed in between the Laser Interferometer Space Antenna (LISA) and pulsar timing arrays, will constitute the largest gap in the coverage of the astrophysically relevant GW spectrum. Yet many outstanding questions related to astrophysics and cosmology are best answered by GW observations in this band. We show that a μ-Hz GW detector will be a truly overarching observatory for the scientific community at large, greatly extending the potential of LISA. Conceived to detect massive black hole binaries from their early inspiral with high signal-to-noise ratio, and low-frequency stellar binaries in the Galaxy, this instrument will be a cornerstone for multimessenger astronomy from the solar neighbourhood to the high-redshift Universe.
Characteristics and Role of Neutrophil Extracellular Traps in Asthma
Authors: Chen Fei , Yu Min , Zhong Yonghong , Wang Lina , Huang Huaqiong 
Published: September 2021

Abstract
Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, structural cells, and neutrophils, which have gained more attention because they secrete substances that play an important role in the occurrence and development of asthma. Neutrophil extracellular traps (NETs) are mesh-like structures composed of DNA, histones, and non-histone molecules that can be secreted from neutrophils. NETs can enrich anti-bacterial substances and limit pathogen migration, thus having a protective effect in case of inflammation. However, despite of their anti-inflammatory properties, NETs have been shown to trigger allergic asthma and worsen asthma progression. Here, we provide a systematic review of the roles of NETs in asthma.
Tariff elimination versus tax avoidance: free trade agreements and transfer pricing
Authors: Mukunoki Hiroshi , Okoshi Hirofumi 
Published: September 2021

AbstractWe explore the new roles of rules of origin (ROO) when multinational enterprises (MNEs) manipulate their transfer prices to avoid a high corporate tax. The ROO under a free trade agreement (FTA) require exporters to identify the origin of exports to be eligible for a preferential tariff rate. We find that a value-added criterion of ROO restricts abusive transfer pricing by MNEs. Interestingly, an FTA with ROO can induce MNEs to shift profits from a low- to high-tax country. Because the ROO augment tax revenues inside FTA countries, they can transform a welfare-reducing FTA into a welfare-improving one.
Between Food and Respect for Nature: On the Moral Ambiguity of Norwegian Stakeholder Opinions on Fish and Their Welfare in Technological Innovations in Fisheries
Authors: Laursen Danielle Caroline , Meijboom Franck L. B. 
Published: September 2021

AbstractInnovation in fisheries is a global development that focuses on a broad range of aims. One example is a project that aims to develop technology for key phases of the demersal fishery operation to improve product quality and safeguard fish welfare. As this step to include welfare is novel, it raises questions associated with stakeholder acceptance in a wider aim for responsible innovation. How do stakeholders (a) value fish and their welfare and (b) consider the relation between welfare and other relevant values? To address these questions, an approach combining desk research with an empirical study was used. The desk study analysed the ethical and biological arguments for whether fish welfare should be accounted for in this context. The empirical study explored how fish and their welfare are perceived by Norwegian professionals in this industry, by conducting semi-structured interviews and subsequently analysing the results based on a labelling method we developed. The desk study showed a consensus that welfare should be considered in its own right, while at face value the interviews presented a rather instrumental view on this theme. However, analysis of the interview results leads to a more nuanced picture, where fish and their welfare are viewed from the perspective of respect for nature. Despite the apparent divergence between stakeholder opinions and the literature on the importance of welfare, we present three steps that enables professionals to be responsive to both the (moral) views of stakeholders and accounting for welfare in the innovation process fisheries.
A rapid heating and high magnetic field thermal analysis technique
Authors: Kesler Michael S. , McGuire Michael A. , Conner Ben , Rios Orlando , Murphy Bart , Carter William , Henderson Hunter B. , Ludtka Gerard M. , Kisner Roger A. 
Published: September 2021

AbstractA new thermal analysis technique is described that allows measurements to be performed on bulk samples at extreme heating and cooling rates and in high magnetic fields. High heating rates, up to 1000 °C min−1, are achieved through electromagnetic induction heating of a custom-built apparatus fitted with commercial thermal analysis heads and sensor. Rapid cooling rates, up to 100 °C min−1, are enabled by gas quenching and the small thermal mass of the induction furnace. The custom apparatus is designed to fit inside a superconducting magnet capable of fields up to 9 Tesla. This study demonstrates that the instrument is capable of collecting accurate thermal analysis data in high magnetic fields and rapidly acquiring data for dynamic processes. While the full potential of the technique is still unrealized, currently, it can provide insight into phenomena at time scales relevant to heat treatment in many industrial processes and into little understood effects of high magnetic field processing.
Chatbot breakthrough in the 2020s? An ethical reflection on the trend of automated consultations in health care
Authors: Parviainen Jaana , Rantala Juho 
Published: September 2021

AbstractMany experts have emphasised that chatbots are not sufficiently mature to be able to technically diagnose patient conditions or replace the judgements of health professionals. The COVID-19 pandemic, however, has significantly increased the utilisation of health-oriented chatbots, for instance, as a conversational interface to answer questions, recommend care options, check symptoms and complete tasks such as booking appointments. In this paper, we take a proactive approach and consider how the emergence of task-oriented chatbots as partially automated consulting systems can influence clinical practices and expert–client relationships. We suggest the need for new approaches in professional ethics as the large-scale deployment of artificial intelligence may revolutionise professional decision-making and client–expert interaction in healthcare organisations. We argue that the implementation of chatbots amplifies the project of rationality and automation in clinical practice and alters traditional decision-making practices based on epistemic probability and prudence. This article contributes to the discussion on the ethical challenges posed by chatbots from the perspective of healthcare professional ethics.
A domain specific language notation for a language learning activity generation tool
Authors: Sebastián Gabriel , Tesoriero Ricardo , Gallud Jose A. 
Published: September 2021

AbstractGlobalization has increased the need for society to master new languages. This need has encouraged the launch of many applications dedicated to language learning. This paper presents a graphical notation for a domain specific language to represent language learning activities. It describes how this notation enables developers to represent language learning activity characteristics using workflow, presentation, content, media and activity model conforming a metamodel that defines the abstract syntax of the domain specific language. This notation is implemented as part of an integrated development environment to build model-based applications. Finally, this proposal is evaluated with a framework that uses the cognitive dimensions of notations for notational systems. The proposed graphic diagram editor exceeds the experience that the user has with the reflexive model editor. In relation to the creation and editing of workflow models and presentation/activity models, the proposed graphical notation its more intuitive and easy to maintain visually than the traditional reflexive tree notation used by many model-based development frameworks.
When does personalization work on social media? a posteriori segmentation of consumers
Authors: Serrano-Malebrán Jorge , Arenas-Gaitán Jorge 
Published: September 2021

AbstractThe aim of this research is to find a segment of consumers of fashion products based on their personal visions of personalization of shoppable ads on mobile social media. To meet this objective, three operational objectives are defined. First, a theoretical model is evaluated based on the stimulus-organism-response framework (S–O–R). This examines, with a PLS-SEM approach, how the stimulation of personalization will affect consumers' internal cognitive state (perceived usefulness) and consequently generates a behavioral response (intention to buy). Second, we look for fashion consumer segments based on their perception of personalization through prediction-oriented segmentation (PLS-POS). Third, the segments are explained based on three constructs that were considered important in fashion consumption through mobile social networks: purchase intention, concern for privacy, and perception of trend. The inclusion of personalization and the perception of usefulness of advertisements can greatly help the intention to purchase clothing to be understood. The application of a posterior segmentation helps to better understand the different types of users exposed to shoppable ads on mobile social networks and their relationship with the purchase intention, concern for privacy and trend. While the measures and scales were tested in a context of mobile clothing trade, the methodology can be applied to other types of products or services.
Fungal Genomics in Respiratory Medicine: What, How and When?
Authors: Brackin Amelie P. , Hemmings Sam J. , Fisher Matthew C. , Rhodes Johanna 
Published: September 2021

AbstractRespiratory infections caused by fungal pathogens present a growing global health concern and are a major cause of death in immunocompromised patients. Worryingly, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome has been shown to predispose some patients to airborne fungal co-infections. These include secondary pulmonary aspergillosis and mucormycosis. Aspergillosis is most commonly caused by the fungal pathogenAspergillus fumigatusand primarily treated using the triazole drug group, however in recent years, this fungus has been rapidly gaining resistance against these antifungals. This is of serious clinical concern as multi-azole resistant forms of aspergillosis have a higher risk of mortality when compared against azole-susceptible infections. With the increasing numbers of COVID-19 and other classes of immunocompromised patients, early diagnosis of fungal infections is critical to ensuring patient survival. However, time-limited diagnosis is difficult to achieve with current culture-based methods. Advances within fungal genomics have enabled molecular diagnostic methods to become a fast, reproducible, and cost-effective alternative for diagnosis of respiratory fungal pathogens and detection of antifungal resistance. Here, we describe what techniques are currently available within molecular diagnostics, how they work and when they have been used.
Nonlinear energy-based control of soft continuum pneumatic manipulators
Authors: Franco Enrico , Ayatullah Tutla , Sugiharto Arif , Garriga-Casanovas Arnau , Virdyawan Vani 
Published: September 2021

AbstractThis paper investigates the model-based nonlinear control of a class of soft continuum pneumatic manipulators that bend due to pressurization of their internal chambers and that operate in the presence of disturbances. A port-Hamiltonian formulation is employed to describe the closed loop system dynamics, which includes the pressure dynamics of the pneumatic actuation, and new nonlinear control laws are constructed with an energy-based approach. In particular, a multi-step design procedure is outlined for soft continuum manipulators operating on a plane and in 3D space. The resulting nonlinear control laws are combined with adaptive observers to compensate the effect of unknown disturbances and model uncertainties. Stability conditions are investigated with a Lyapunov approach, and the effect of the tuning parameters is discussed. For comparison purposes, a different control law constructed with a backstepping procedure is also presented. The effectiveness of the control strategy is demonstrated with simulations and with experiments on a prototype. To this end, a needle valve operated by a servo motor is employed instead of more sophisticated digital pressure regulators. The proposed controllers effectively regulate the tip rotation of the prototype, while preventing vibrations and compensating the effects of disturbances, and demonstrate improved performance compared to the backstepping alternative and to a PID algorithm.
Supererogation and conditional obligation
Authors: Muñoz Daniel , Pummer Theron 
Published: September 2021

AbstractThere are plenty of classic paradoxes about conditional obligations, like the duty to be gentle if one is to murder, and about “supererogatory” deeds beyond the call of duty. But little has been said about the intersection of these topics. We develop the first general account of conditional supererogation, with the power to solve familiar puzzles as well as several that we introduce. Our account, moreover, flows from two familiar ideas: that conditionals restrict quantification and that supererogation emerges from a clash between justifying and requiring reasons.