bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D level and telogen hair loss: A Case control study
Authors: Turkan Taiceer A. , Al-Rawi Jamal R. 
Published: November 2021

Abstract

Background: Hair loss is a common skin condition. Hair is not a vital organ but losing it has a worse effect on the psychological state of the patient and may interrupt his daily social activities. Telogen effluvium founded to be the commonest noninflammatory cause to diffuse hair loss. Since nutritional disturbances are one of the triggering factors for it. It might be useful in the management of TE Due to the limited number of studies& little information is available on this subject possible role of vitamin D or its deficiency should be studied further.
Aim of the study: to determine the association between Telogen effluvium and vitamin D level.
Materials and methods: This is a case-control study performed in a period between December 2018 until June 2020; in Baghdad dermatology center at medical city. One hundred women who were seeking treatment for diffuse hair shedding and who hadn’t received treatment or supplements yet and One hundred fifty control subjects are chosen from patients who were referred to the dermatology clinic for the treatment of nevi and who are not pregnant or lactating, had no systemic or local scalp diseases are included in the study. Full History, physical examination performed for all cases including looking for cutaneous diseases, supplements & drug intake. Serum Vitamin D3 is measured using (Ichroma (TM), Boditech Med Inc., Korea).
Result: A total of 250 females were included in this study, 100 of them got telogen effluvium & 150 were patients who attend dermatology clinic seeking treatments for nevi or skin tag (control group) .The mean age of cases was (22.59 ±4.837 year) that wasn’t significantly different from mean age of control group (23.647±6.022 years) (p-value =0.127). The mean level of Vitamin D was significantly lower than that of control group (11.16±4.49) Vs (18.98±10.65), P value <0.001. Vitamin D mean level in acute phase was significantly higher than that of chronic phase pts. (11.68±4.77 & 9.93 ±3.55 respectively), p value=0.04. Mean vit. D among symptomatic patients. (9.7 ± 3.5) was significantly lower than that among asymptomatic pts. (13±4.19) (p=0.001).No significant association were noticed between job & residence of the patients of both groups, (P-value =0.283 & 0.069 respectively (.
Conclusion: Age mean difference was not significant among cases and controls. Deficiency in vitamin D may assume a possible leading cause of telogen effluvium among women with hair loss. Cases were significantly associated with low level of Vitamin D3 than controls.Low level of vitamin D was dominant among housewives, urban women, and among symptomatic patients with acute duration.
Missed foreign body inhalation for 15-years
Authors: Hussen Waleed M. 
Published: November 2021

Background:
Foreign body inhalation is a life threating event in children and it is common in our country ,which is a daily practice of Thoracic .It can lead to morbidity even mortality in the hands of untrained or not well- trained doctors.
Aim:
Is to report a case of missed foreign body inhaled 15-years back, which is uncommonly reported in the literatures and to compare it with other studies reporting similar cases.
Methods:
The details, presentation, clinical findings, radiological appearance and the successful removal by a rigid bronchoscope under general anesthesia will be presented.
Results:
The successful removal of this long standing impacted foreign body (plastic whistle) using the rigid bronchoscope and the eventful outcome of patient’s clinical symptoms is elucidated.
Conclusion:
Refractory respiratory symptoms of long duration without improvement justify the need for diagnostic bronchoscopy which will offers the best chance of cure in missed foreign body inhalation.
Implementasi Metode Saintifik oleh Guru PAI di SMA Se-Aceh
Authors: Abidin Zainal 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pemahaman guru Pendidikan Agama Islam (PAI) tentang metode saintifik dalam implementasi kurikulum 2013 dalam merancang dan melaksanakan pembelajaran PAI pada Sekolah Menengah Atas (SMA) Provinsi Aceh. Desain penelitian ini menggunakan pendekatan kuantitatif dan kualitatif (mixed method concurrent nested/concurrent embedded strategy) yang dilaksanakan pada 102 sekolah dengan menggunakan instrumen kuesioner dan 12 sekolah menggunakan instrumen wawancara. Penelitian ini melibatkan 211 guru PAI yang dipilih melalui persampelan porposive sampling, simple random sampling dan cluster sampling persampelan untuk kuantitatif dan 12 responden untuk kualitatif. Analisis data penelitian kuantitatif menggunakan statistik inferensi melalui analisis uji-t serta menggunakan analisis data wawancara untuk kualitatif. Hasil penelitian menunjukkan terdapat perbedaan yang signifikan kemampuan guru PAI dalam memahami metode saintifik berdasarkan pada substansi kurikulum 2013. Ini menunjukkan bahwa guru PAI wilayah dalam Kota lebih memahami metode pembelajaran saintifik dibandingkan dengan guru PAI luar Kota.
Faktor yang Berhubungan dengan Tindakan Tidak Aman pada Pekerja di PT. Industri Kapal Indonesia (Persero) Makassar
Authors: Siti Chaerun Nisa  , Suharni A. Fachrin  
Published: November 2021

International Labour Organization (ILO) mengatakan bahwa sekitar 6.400 orang meninggal dunia setiap harinya karena kecelakaan akibat kerja dan sekitar 860.000 orang yang terluka di tempat kerja. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan tindakan tidak aman (unsafe action) pada pekerja di PT. Industri Kapal Indonesia (Persero) Kota Makassar. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan metode sampel penelitian cross sectional. Populasi penelitian sebanyak 104 pekerja, sampel penelitian sebanyak 50 pekerja yang diambil secara simple random sampling dari pekerja bagian produksi PT. Industri Kapal Indonesia (Persero) Kota Makassar. Cara pengambilan data melakukan observasi, wawancara dan dokumentasi dengan menggunakan kuesioner, alat tulis dan kamera. Teknik pengambilan data menggunakan uji korelasi Chi-square pada program SPSS versi 23 dengan tingkat kepercayaan 95% (α=0,05). Ada hubungan antara masa kerja dengan tindakan tidak aman (p= 0,009), ada hubungan antara pengetahuan dengan tindakan tidak aman (p=0,010) ada hubungan antara kelelahan kerja dengan tindakan tidak aman (p = 0,003), tidak ada hubungan antara pengawasan dengan tindakan tidak aman (p = 0,825) dan tidak ada hubungan antara pelatihan dengan tindakan tidak aman (p= 0,411) pada pekerja bagian produksi PT. Industri Kapal Indonesia (Persero) Kota Makassar. Diharapkan pihak perusahaan membeikan pengetahuan atau arahan K3 kepada pekerja untuk mengendalikan tindakan tidak aman secara rutin seperti saat sebelum memulai aktivitas kerja, bagi pekerja apabila perasaan lelah dan tegang datang dan tidak tertahankan, sebaiknya beristirahat sejenak dan melakukan gerakan senam ringan untuk meredakan ketegangan otot tersebut.
Komunikasi Berhungan dengan Pengetahuan Ibu Hamil dalam Mencegah Tanda-Tanda Bahaya Kehamilan
Authors: Srirezeki Wa Ode Nurdian , Yusriani  , Idris Fairus Prihatin 
Published: November 2021

Selama kurun waktu lima tahun terakhir Angka Kematian Ibu (AKI) di Sulawesi Tenggara yaitu tahun 2013 AKI berjumlah 79 orang, tahun 2014 AKI berjumlah 65 orang, tahun 2015 AKI berjumlah 67 orang, tahun 2016 AKI berjumlah 74 orang dan tahun 2017 AKI berjumlah 75 orang (Dinas Kesehatan Provinsi Sulawesi Tenggara, 2017). Jenis penelitian yang digunakan adalah penelitian kuantitatif, menggunakan desain penelitian cross sectional yang bertujuan untuk mengetahui hubungan komunikasi bidan dengan pengetahuan ibu hamil dalam mencegah tanda-tanda bahaya kehamilan. Populasi dalam penelitian sebanyak 107 ibu hamil.Pengambilan sampel dalam penelitian ini menggunakan probability sampling dengan Teknik simple random sampling.Data yang dikumpulkan kemudian diolah secara manual dengan menggunakan SPSS. Hasil penelitian menunjukkan bahwa didapatkan sebanyak 3 responden (3.6%) ibu hamil yang memiliki pengetahuan kurang dan yang memiliki pengetahuan cukup sebanyak 81 (96.4%), sehingga tidak ada hubungan antara komunikasi bidan dengan pengetahuan ibu hamil dengan nilai p (value) = 0,673. Di harapkan pada peneliti selanjutnya sebaiknya meneliti hubungan komunikasi bidan dengan pengetahuan ibu hamil dalam mencegah tanda-tanda bahaya kehamilan.lebih efektif.
Faktor yang Berhubungan dengan Kualitas Hidup Pasien Chronic Kidney Disease yang Menjalani Hemodialisis di RSUD Labuang Baji Kota Makassar
Authors: Akrianti Putri Anggun , Sumiaty  , Yuliati  
Published: November 2021

Chronic kidney disease merupakan suatu kondisi penurunan progresif fungsi ginjal selama periode bulan atau tahun. Tahap akhir dari gagal ginjal kronik sering disebut dengan End Stage Renal Disease (ESRD). Dalam penyakit ginjal stadium akhir ini, ginjal kehilangan fungsinya secara irreversibel untuk mempertahankan metabolisme dan homeostasis tubuh. Apabila pasien telah mengalami Gagal Ginjal Kronik stadium berat, untuk mempertahankan hidupnya diperlukan terapi sementara berupa hemodialisis. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan kualitas hidup pasien chronic kidney disease yang menjalani hemodialysis di RSUD Labuang Baji Kota Makassar. Metode penelitian deskriptif analitik dengan pendekatan Cross Sectional Study dengan menggunakan kuesioner. Populasi dalam penelitian ini yaitu seluruh pasien gagal ginjal kronik yang menjalani hemodialisis di RSUD Labuang Baji Kota Makassar yang berjumlah 31 responden. Data dianalisis yang menggunakan uji chi square. Hasil penelitian yang diperoleh yaitu, ada hubungan dukungan keluarga dengan kualitas hidup pasien gagal ginjal kronik yang menjalani hemodialisis di RSUD Labuang Baji Kota Makassar dengan nilai p-value 0,021< 0,05 dan ada hubungan depresi dengan kualitas hidup pasien gagal ginjal kronik yang menjalani hemodialisis di RSUD Labuang Baji Kota Makassar dengan nilai p-value 0,034 < 0,05.Diharapkan bagi keluarga pasien gagal ginjal kronik yang menjalani hemodialisis untuk selalu memberikan dukungan kepada anggota keluarganya yang memiliki penyakit gagal ginjal kronik yang menjalani hemodialisis untuk pasien gagal ginjal kronis yang menjalani hemodialisis harus selalu berpikiran positif untuk menghindari terjadinya depresi.
Pengaruh Disiplin Kerja dan Kompetensi terhadap Kinerja Dosen AMIK Medicom
Authors: Br Sembiring Dinaria 
Published: November 2021

Penelitian ini dilakukan untuk mengetahui bagaimana pengaruh disiplin kerja (X1) dan kompetensi (X2) terhadap kinerja dosen (Y) pada Akademi Manajemen Informatika Komputer Medicom. Jenis penelitian yang digunakan adalah explanatory research melalui penelitian asosiatif, yaitu penelitian yang bertujuan untuk menjelaskan pengaruh antara dua variabel atau lebih. Populasi dalam penelitian ini adalah seluruh dosen Akademi Manajemen Informatika dan Komputer Medicom Medan berjumlah 35 orang. Metode pengumpulan data dilakukan dengan kuesioner . studi kepustakaan, dan observasi. Analisis data dilakukan dalam penelitian ini adalah uji hipotesis dengan uji t (uji parsial) dan uji F (uji simultan). Hasil penelitian ini diperoleh bahwa : (1) berdasarkan uji parsial disiplin kerja Berpengaruh terhadap kinerja Dosen pada Akademi Manajemen Informatika Komputer Medicom dengan uji t sebesar 3.724. (2) Berdasarkan uji parsial Kompetensi berpengaruh terhadap kinerja Dosen Akademi Manajemen Informatika Komputer Medicom dengan uji t sebesar 4.065 (3) Berdasarkan uji Simultan bengaruh disiplin kerja dan kompetensi terhadap kinerja Dosen AMIK Medicom dengan uji F sebesar 54.416.
O FUTURO DO EMPREGO E O PROFISSIONAL DO FUTURO
Authors: Ramos Mota Junior José Dimas , Maria Andrade Brisola Elisa 
Published: November 2021

P
Pensar no profissional do futuro tem sido uma das principais preocupações individuais e coletivas nos últimos anos. A indústria que até então era fonte dos “melhores” empregos, com o advento da 4ª Revolução Industrial, parece precisar cada vez menos da mão de obra humana. Nesse contexto, o Fórum Econômico Mundial publicou, em 2018, o relatório intitulado “O Futuro dos Empregos”, no qual compila dados e opiniões dos maiores empregadores mundiais acerca do futuro dos empregos, as exigências e adaptações necessárias para atender aos requisitos da 4ª Revolução Industrial. As análises e cenários traçados tinham um horizonte temporal de 5 anos (2018-2022), porém após o início da crise, em decorrência da pandemia de COVID-19, um novo relatório foi publicado com o mesmo nome, formato e horizonte de tempo (2020-2025). Esse artigo utiliza a metodologia de pesquisa bibliográfica para trazer uma leitura crítica do relatório de 2018, bem como sua comparação com o relatório de 2020. Os dados contidos nos relatórios com relação ao Brasil são colocados para um recorte local e identificação da situação nacional. Conclui-se que os dados dos dois relatórios são uteis para as análises, contudo em uma análise crítica questiona-se a abrangência dos grupos pesquisados, assim como a perspectiva positiva do relatório de 2018, reduzida em 2020 ainda que mantido o viés positivo. Por fim, ponderamos que os problemas que a 4ª Revolução Industrial já vem causando pelo mundo podem se agravar, principalmente em países como o Brasil que tem historicamente questões como por exemplo a desigualdade social que pode se aprofundar no contexto estudado.
Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
Authors: Liu Taisheng , Guo Liyi , Liu Guihong , Hu Xiaoshan , Li Xiaoning , Zhang Jinye , Dai Zili , Yu Peng , Jiang Ming , Wang Jian , Zhang Jian 
Published: November 2021

Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis. Nonetheless, the potential roles of 5mC regulators in the tumor microenvironment (TME) remain unclear.Methods: The 5mC modification patterns of 1,374 lung adenocarcinoma samples were analyzed systematically. The correlation between the 5mC modification and tumor microenvironment cell infiltration was further assessed. The 5mCscore was developed to evaluate tumor mutation burden, immune check-point inhibitor response, and the clinical prognosis of individual tumors.Results: Three 5mC modification patterns were established based on the clinical characteristics of 21 5mC regulators. According to the differential expression of 5mC regulators, three distinct 5mC gene cluster were also identified, which showed distinct TME immune cell infiltration patterns and clinical prognoses. The 5mCscore was constructed to evaluate the tumor mutation burden, immune check-point inhibitor response, and prognosis characteristics. We found that patients with a low 5mCscore had significant immune cell infiltration and increased clinical benefit.Conclusion: This study indicated that the 5mC modification is involved in regulating TME infiltration remodeling. Targeting 5mC modification regulators might be a novel strategy to treat lung cancer.
Lanthanum Oxide Nickel Hydroxide Composite Triangle Nanosheets for Energy Density Asymmetric Supercapacitors
Authors: Duan Huiyu , Shi Mei , Zhang Mengfei , Feng Geyu , Liu Suli , Chen Changyun 
Published: November 2021

Transition metal hydroxides are a kind of promising electrode material in electrochemical energy storage, but the poor conductivity limits their application. Lanthanides are good proton conductors and can usually improve the intrinsic conductivity of other materials. By integrating the merits of lanthanide elements and transition metal hydroxide, we designed lanthanum oxide nickel hydroxide composites (LONH) with unique ultrathin triangle nanosheet morphology via a controllable synthetic strategy for high-performance supercapacitors. When the LONH is used as positive electrode material in aqueous asymmetric supercapacitor, it reveals an energy density (107.8 W h kg−1 at 800 W kg−1), rate performance (86.9% retention at 4 kW kg−1) and outstanding cycle stability (more than 90% retention after 3,000 cycles). This work confirms that compositing La2O3 and Ni(OH)2 can significantly improve the supercapacitor performance of both pristine La2O3 and transition metal hydroxide composites. We hope this work would offer a good prospect for developing other lanthanide-transition metal hydroxide composites as an attractive class of electrode materials in electrochemical energy storage.
Causal Relationship Between Lung Function and Atrial Fibrillation: A Two Sample Univariable and Multivariable, Bidirectional Mendelian Randomization Study
Authors: Zhang Qiaoyun , Zhang Xiaoyu , Zhang Jie , Wang Biyan , Meng Xiaoni , Tian Qiuyue , Zhang Jinxia , Jiang Mengyang , Zhang Yiqiang , Zheng Deqiang , Wu Lijuan , Wang Wei , Wang Baoguo , Wang Youxin 
Published: November 2021

Background: Observational studies have identified impaired lung function accessed by forced expiratory volume in one second (FEV1), forced vital capacity (FVC) or the ratio of FEV1 over FVC (FEV1/FVC) as an independent risk factor for atrial fibrillation (AF). However, the result may be affected by confounders or reverse causality.Methods: We performed univariable MR (uvMR), multivariable MR (mvMR) and bidirectional two-sample MR to jointly estimate the causality of lung function with AF. Apart from the inverse variance weighted (IVW) approach as the main MR analysis, three complementary sensitive analyses approaches including MR-Egger regression, weighted median (WM) MR and Pleiotropy Residual Sum and Outlier (MR-PRESSO) in uvMR as well as mvMR-Egger and mvMR-PRESSO in mvMR were applied to control for pleiotropy. Linkage disequilibrium score (LDSC) regression was applied to estimate genetic correlation between lung function and AF.Results: All forward and reverse uvMR analyses consistently suggested absent causal relations between lung function and AF risk [forward IVW: odds ratio (OR)FEV1 = 1.031, 95% CI = 0.909–1.169, P = 0.630; ORFVC = 1.002, 95% CI = 0.834–1.204, P = 0.982; ORFEV1/FVC = 1.076, 95% CI = 0.966–1.199, P = 0.182; reverse IVW: ORFEV1 = 0.986, 95% CI = 0.966–1.007, P = 0.187; ORFVC = 0.985, 95% CI = 0.965–1.006, P = 0.158; ORFEV1/FVC = 0.994, 95% CI = 0.973–1.015, P = 0.545]. The forward MR-Egger showed that each standard deviation (SD) increase in FEV1/FVC was related to a higher AF risk (OR = 1.502, 95% CI = 1.178–1.915, P = 0.006) without heterogeneity (Q_pval = 0.064), but pleiotropy effect exist (intercept = −0.017, P = 0.012). However, this significant effect disappeared after adjustment of FEV1 and FVC (OR = 1.523, 95% CI = 0.445–5.217, P = 0.503) in mvMR. No evidence was found for independent causal effects of FEV1 and FVC on AF in mvMR analysis by using mvIVW method (ORFEV1 = 0.501, 95% CI = 0.056–4.457, P = 0.496; ORFVC = 1.969, 95% CI = 0.288–13.474, P = 0.490). Notably, the association between lung function and AF were replicated using the FinnGen cohort data.Conclusions: Our findings reported no coheritability between lung function and AF, and failed to find substantial causal relation between decreased lung function and risk of AF. However, lung function and AF were both associated with inflammation, which may be potential pathway, warranting further study.
Integrated Analysis of Hub Genes and MicroRNAs in Human Placental Tissues from In Vitro Fertilization-Embryo Transfer
Authors: Yang Shuheng , Zheng Wei , Yang Chen , Zu Ruowen , Ran Shiyu , Wu Huan , Mu Mingkun , Sun Simin , Zhang Nana , Thorne Rick F. , Guan Yichun 
Published: November 2021

ObjectiveSupraphysiological hormone exposure, in vitro culture and embryo transfer throughout the in vitro fertilization-embryo transfer (IVF-ET) procedures may affect placental development. The present study aimed to identify differences in genomic expression profiles between IVF-ET and naturally conceived placentals and to use this as a basis for understanding the underlying effects of IVF-ET on placental function.MethodsFull-term human placental tissues were subjected to next-generation sequencing to determine differentially expressed miRNAs (DEmiRs) and genes (DEGs) between uncomplicated IVF-ET assisted and naturally conceived pregnancies. Gene ontology (GO) enrichment analysis and transcription factor enrichment analysis were used for DEmiRs. MiRNA-mRNA interaction and protein-protein interaction (PPI) networks were constructed. In addition, hub genes were obtained by using the STRING database and Cytoscape. DEGs were analyzed using GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Differentially expressed miRNAs were validated through qRT-PCR.ResultsCompared against natural pregnancies, 12 DEmiRs and 258 DEGs were identified in IVF-ET placental tissues. In a validation cohort, it was confirmed that hsa-miR-204-5p, hsa-miR-1269a, and hsa-miR-941 were downregulation, while hsa-miR-4286, hsa-miR-31-5p and hsa-miR-125b-5p were upregulation in IVF-ET placentas. Functional analysis suggested that these differentially expressed genes were significantly enriched in angiogenesis, pregnancy, PI3K-Akt and Ras signaling pathways. The miRNA-mRNA regulatory network revealed the contribution of 10 miRNAs and 109 mRNAs while EGFR was the most highly connected gene among ten hub genes in the PPI network.ConclusionEven in uncomplicated IVF-ET pregnancies, differences exist in the placental transcriptome relative to natural pregnancies. Many of the differentially expressed genes in IVF-ET are involved in essential placental functions, and moreover, they provide a ready resource of molecular markers to assess the association between placental function and safety in IVF-ET offspring.
Comprehensive Analysis of N6-Methyladenosine (m6A) Methylation in Neuromyelitis Optica Spectrum Disorders
Authors: Yang Hong , Wu Yi-Fan , Ding Jie , Liu Wei , Zhu De-Sheng , Shen Xia-Feng , Guan Yang-Tai 
Published: November 2021

Background: N6-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA. But its role in neuromyelitis optica spectrum disorders (NMOSD) is not known.Aims: To explore the mechanism of m6A in NMOSD patients.Methods: This study assessed the m6A methylation levels in blood from two groups: NMOSD patients and healthy controls. Methylated RNA immunoprecipitation Sequencing (MeRIP-seq) and RNA-seq were performed to assess differences in m6A methylation between NMOSD patients and healthy controls. Ultra-high performance liquid chromatography coupled with triple quadruple mass spectrometry (UPLC-QQQ-MS) method was performed to check m6A level. Differential m6A methylation genes were validated by MeRIP-qPCR.Results: Compared with that in the control group, the total m6A level was decreased in the NMOSD group. Genes with upregulated methylation were primarily enriched in processes associated with RNA splicing, mRNA processing, and innate immune response, while genes with downregulated methylation were enriched in processes associated with the regulation of transcription, DNA-templating, and the positive regulation of I-kappa B kinase/NF-kappa B signalling.Conclusion: These findings demonstrate that differential m6A methylation may act on functional genes to regulate immune homeostasis in NMOSD.