bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards an open and effective dialogue on complementary medicine in oncology: protocol of patient participatory study ‘COMMON’
Authors: Mentink Marit , Noordman Janneke , Busch Martine , van Vliet Liesbeth , Timmer-Bonte Johanna (Anja) , van Dulmen Sandra 
Published: October 2021

IntroductionApproximately half of patients with cancer use some form of complementary medicine alongside conventional cancer treatment. The topic of complementary medicine often remains undiscussed in consultations between patients with cancer and their healthcare providers. This results in increased risks for adverse or interaction effects and decreased access to the benefits of evidence-based complementary medicine for patients with cancer. This paper describes the design of patient participatory study titled ‘COMMON’ that aims to explore and enhance open and effective communication about complementary medicine in oncology. The study is carried out in collaboration with 12 (former) patients with breast cancer as coresearchers.Methods and analysisThe study complies with the six steps of the intervention mapping framework. Three non-academic hospitals recruit participants (patients with cancer, oncology healthcare providers and managers) for interviews about the organisation, experiences and needs regarding complementary medicine. To assess communication about complementary medicine, recorded oncology consultations are analysed. For an overview of evidence-based complementary medicine available to patients with cancer, a review of reviews is conducted on the evidence on cancer patient-reported outcomes of complementary medicine frequently used by patients with cancer, supplemented with an online search and survey among organisations and persons providing complementary medicine to patients with cancer. Together, these steps generate input for the development of a toolbox that supports an open and effective discussion on complementary medicine in oncology. In a pilot study, acceptability and usability of the toolbox are assessed among patients with cancer and oncology healthcare providers. Dissemination of the toolbox is covered by the commitment of stakeholder parties.Ethics and disseminationThe Medical Ethics Committee Arnhem-Nijmegen declared the study was exempted from formal approval under the Dutch Medical Research Involving Human Subjects Act. The results will be disseminated through open-access, peer-reviewed publications, stakeholder-reporting and presentations at relevant conferences.
Effects of in situ wetting–drying cycles on the mechanical behaviour of an intact loess
Authors: Mu Q.Y. , Dong H. , Liao H.J. , Zhou C. , Li S.B. , Zhang J.W. 
Published: October 2021

In situ wetting–drying cycles significantly and repeatedly influence the soil water content in the active zone but not in the steady zone. To investigate effects of in situ wetting–drying cycles on the mechanical behaviour of intact loess, a series of pressure plate tests was carried out with an intact loess sampled from the active and steady zones. Results show that the specimens from the steady zone have higher yield stresses at given suctions and a larger inclination of normalized loading collapse (LC) curve than the specimens from the active zone. As evidenced by the scanning electron microscopy results, the clay particles accumulating around the contacts between silt particles are widely observed in the former specimens but not in the latter specimens. The distribution of clay particles in the former specimens results in a stabilized skeleton with mechanical properties sensitive to suction variations. On the other hand, the maximum collapse potential of the specimen from the steady zone is 37% larger than that of the specimen from the active zone, mainly because of the larger inclination of normalized LC curve owned by the former specimen.
Static magnetic susceptibility in finite-density $$SU\left( 2\right) $$ lattice gauge theory
Authors: Buividovich P. V. , Smith D. , von Smekal L. 
Published: October 2021

AbstractWe study static magnetic susceptibility $$\chi (T, \mu )$$

χ
(
T
,
μ
)

in SU(2) lattice gauge theory with $$N_f = 2$$

N
f

=
2

light flavours of dynamical fermions at finite chemical potential $$\mu $$
μ
. Using linear response theory we find that SU(2) gauge theory exhibits paramagnetic behavior in both the high-temperature deconfined regime and the low-temperature confining regime. Paramagnetic response becomes stronger at higher temperatures and larger values of the chemical potential. For our range of temperatures $$0.727 \le T/T_c \le 2.67$$

0.727
≤
T
/

T
c

≤
2.67

, the first coefficient of the expansion of $$\chi \left( T, \mu \right) $$

χ

T
,
μ

in even powers of $$\mu /T$$

μ
/
T

around $$\mu =0$$

μ
=
0

is close to that of free quarks and lies in the range $$(2, \ldots , 5) \cdot 10^{-3}$$

(
2
,
…
,
5
)

·

10

-
3

. The strongest paramagnetic response is found in the diquark condensation phase at $$\mu >m\pi /2$$

μ
>
m
π
/
2

.
Casimir wormholes in $$2+1$$ dimensions with applications to the graphene
Authors: Alencar G. , Bezerra V. B. , Muniz C. R. 
Published: October 2021

AbstractIn this paper we show that wormholes in (2+1) dimensions (3-D) cannot be sourced solely by both Casimir energy density and tension, differently from what happens in a 4-D scenario, in which case it has been shown recently, by the direct computation of the exact shape and redshift functions of a wormhole solution, that this is possible. We show that in a 3-D spacetime the same is not true since the arising of at least an event horizon is inevitable. We do the analysis for massive and massless fermions, as well as for scalar fields, considering quasi-periodic boundary conditions and find that a possibility to circumvent such a restriction is to introduce, besides the 3-D Casimir energy density and tension, a cosmological constant, embedding the surface in a 4-D manifold and applying a perpendicular weak magnetic field. This causes an additional tension on it, which contributes to the formation of the wormhole. Finally, we discuss the possibility of producing the condensed matter analogous of this wormhole in a graphene sheet and analyze the electronic transport through it.
Casimir-Lifshitz pressure on cavity walls
Authors: Romaniega C. 
Published: October 2021

AbstractWe extend our previous work on the electromagnetic Casimir-Lifshitz interaction between two bodies when one is contained within the other. We focus on the fluctuation-induced pressure acting on the cavity wall, which is assumed to be spherical. This pressure can be positive or negative depending on the response functions describing the bodies and the medium filling the cavity. However, we find that under general hypotheses, the sign is independent of the geometry of the configuration. This result is based on the representation of the Casimir-Lifshitz energy in terms of transition operators. In particular, we study the components of these operators related to inside scattering amplitudes, adapting the invariant imbedding procedure to this unfamiliar scattering setup. We find that our main result is in agreement with the Dzyaloshinskii–Lifshitz–Pitaevskii result, which is obtained as a limiting case.
Exogenous ketosis increases blood and muscle oxygenation but not performance during exercise in hypoxia
Authors: Poffé Chiel , Robberechts Ruben , Podlogar Tim , Kusters Martijn , Debevec Tadej , Hespel Peter 
Published: October 2021

Available evidence indicates that elevated blood ketones are associated with improved hypoxic tolerance in rodents. From this perspective, we hypothesized that exogenous ketosis by oral intake of the ketone ester ( R)-3-hydroxybutyl ( R)-3-hydroxybutyrate (KE) may induce beneficial physiological effects during prolonged exercise in acute hypoxia. As we recently demonstrated KE to deplete blood bicarbonate, which per se may alter the physiological response to hypoxia, we evaluated the effect of KE both in the presence and absence of bicarbonate intake (BIC). Fourteen highly trained male cyclists performed a simulated cycling race (RACE) consisting of 3-h intermittent cycling (IMT180′) followed by a 15-min time-trial (TT15′) and an all-out sprint at 175% of lactate threshold (SPRINT). During RACE, fraction of inspired oxygen ([Formula: see text]) was gradually decreased from 18.6% to 14.5%. Before and during RACE, participants received either 1) 75 g of ketone ester (KE), 2) 300 mg/kg body mass bicarbonate (BIC), 3) KE + BIC, or 4) a control drink in addition to 60 g of carbohydrates/h in a randomized, crossover design. KE counteracted the hypoxia-induced drop in blood ([Formula: see text]) and muscle oxygenation by ∼3%. In contrast, BIC decreased [Formula: see text] by ∼2% without impacting muscle oxygenation. Performance during TT15′ and SPRINT were similar between all conditions. In conclusion, KE slightly elevated the degree of blood and muscle oxygenation during prolonged exercise in moderate hypoxia without impacting exercise performance. Our data warrant to further investigate the potential of exogenous ketosis to improve muscular and cerebral oxygenation status, and exercise tolerance in extreme hypoxia.
Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
Authors: Swain Christopher T.V. , Drummond Ann E. , Boing Leonessa , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Dixon-Suen Suzanne C. , Lynch Michael J. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M. 
Published: October 2021

Abstract
The effect of physical activity on breast cancer risk may be partly mediated by sex steroid hormones. This review synthesized and appraised the evidence for an effect of physical activity on sex steroid hormones. Systematic searches were performed using MEDLINE (Ovid), EMBASE (Ovid), and SPORTDiscus to identify experimental studies and prospective cohort studies that examined physical activity and estrogens, progestins, and/or androgens, as well as sex hormone binding globulin (SHBG) and glucocorticoids in pre- and postmenopausal women. Meta-analyses were performed to generate effect estimates. Risk of bias was assessed, and the GRADE system was used to appraise quality of the evidence. Twenty-eight randomized controlled trials (RCT), 81 nonrandomized interventions, and six observational studies were included. Estrogens, progesterone, and androgens mostly decreased, and SHBG increased, in response to physical activity. Effect sizes were small, and evidence quality was graded moderate or high for each outcome. Reductions in select sex steroid hormones following exercise supports the biological plausibility of the first part of the physical activity–sex hormone–breast cancer pathway. The confirmed effect of physical activity on decreasing circulating sex steroid hormones supports its causal role in preventing breast cancer.
See related reviews by Lynch et al., p. 11 and Drummond et al., p. 28
Contos de ferrovias de Dmítri Bykov: tradução e intertexto
Authors: Pereira Eloah Pina , Vássina Elena 
Published: October 2021

Ao falarmos de literatura russa contemporânea adentramos em um universo ainda pouco explorado no Brasil. Em relação aos autores mais recentes, pouquíssimos foram traduzidos, publicados ou comentados em português. Dmítri Bykov é um desses autores russos contemporâneos inéditos nas pesquisas brasileiras. Bastante múltiplo, é considerado por críticos como pós-modernista mainstream. Este artigo busca, então, ao apresentá-lo e expor algumas características da obra Contos de ferrovias (ЖД-Рассказы, 2007), investigar quais mecanismos e teorias de tradução podem levar o leitor brasileiro à compreensão não só do texto literário em si, mas do intertexto imanente e contexto da Rússia atual.
Traduzir o Brasil literário: história e crítica, de Marie-Hélène Catherine Torres
Authors: Simoni Karine , Pappen Paulo Henrique 
Published: October 2021

TORRES, Marie-Hélène Catherine. Traduzir o Brasil literário: história e crítica. V. 2. Supervisão de tradução de Germana Henriques Pereira de Sousa; Tradução de Clarissa Prado Marini, Sônia Fernandes e Aída Carla Rangel de Souza. Tubarão: Copiart. Florianópolis: PGET/UFSC, 2014. 397 pg.
Re‐CHARGE‐AF: Recalibration of the CHARGE‐AF Model for Atrial Fibrillation Risk Prediction in Patients With Acute Stroke
Authors: Ashburner Jeffrey M. , Wang Xin , Li Xinye , Khurshid Shaan , Ko Darae , Trisini Lipsanopoulos Ana , Lee Priscilla R. , Carmichael Taylor , Turner Ashby C. , Jackson Corban , Ellinor Patrick T. , Benjamin Emelia J. , Atlas Steven J. , Singer Daniel E. , Trinquart Ludovic , Lubitz Steven A. , Anderson Christopher D. 
Published: October 2021

Background
Performance of existing atrial fibrillation (AF) risk prediction models in poststroke populations is unclear. We evaluated predictive utility of an AF risk model in patients with acute stroke and assessed performance of a fully refitted model.

Methods and Results

Within an academic hospital, we included patients aged 46 to 94 years discharged for acute ischemic stroke between 2003 and 2018. We estimated 5‐year predicted probabilities of AF using the Cohorts for Heart and Aging Research in Genomic Epidemiology for Atrial Fibrillation (CHARGE‐AF) model, by recalibrating CHARGE‐AF to the baseline risk of the sample, and by fully refitting a Cox proportional hazards model to the stroke sample (Re‐CHARGE‐AF) model. We compared discrimination and calibration between models and used 200 bootstrap samples for optimism‐adjusted measures. Among 551 patients with acute stroke, there were 70 incident AF events over 5 years (cumulative incidence, 15.2%; 95% CI, 10.6%–19.5%). Median predicted 5‐year risk from CHARGE‐AF was 4.8% (quartile 1–quartile 3, 2.0–12.6) and from Re‐CHARGE‐AF was 16.1% (quartile 1–quartile 3, 8.0–26.2). For CHARGE‐AF, discrimination was moderate (C statistic, 0.64; 95% CI, 0.57–0.70) and calibration was poor, underestimating AF risk (Greenwood‐Nam D’Agostino chi‐square,
P
<0.001). Calibration with recalibrated baseline risk was also poor (Greenwood‐Nam D’Agostino chi‐square,
P
<0.001). Re‐CHARGE‐AF improved discrimination (
P
=0.001) compared with CHARGE‐AF (C statistic, 0.74 [95% CI, 0.68–0.79]; optimism‐adjusted, 0.70 [95% CI, 0.65–0.75]) and was well calibrated (Greenwood‐Nam D’Agostino chi‐square,
P
=0.97).

Conclusions
Covariates from an established AF risk model enable accurate estimation of AF risk in a poststroke population after recalibration. A fully refitted model was required to account for varying baseline AF hazard and strength of associations between covariates and incident AF.
Tornado Formation and Intensity Prediction Using Polarimetric Radar Estimates of Updraft Area
Authors: French Michael M. , Kingfield Darrel M. 
Published: October 2021

AbstractA sample of 198 supercells are investigated to determine if a radar proxy for the area of the storm midlevel updraft may be a skillful predictor of imminent tornado formation and/or peak tornado intensity. A novel algorithm, a modified version of the Thunderstorm Risk Estimation from Nowcasting Development via Size Sorting (TRENDSS) algorithm is used to estimate the area of the enhanced differential radar reflectivity factor (ZDR) column in Weather Surveillance Radar – 1988 Doppler data; the ZDR column area is used as a proxy for the area of the midlevel updraft. The areas of ZDR columns are compared for 154 tornadic supercells and 44 non-tornadic supercells, including 30+ supercells with tornadoes rated EF1, EF2, and EF3; nine supercells with EF4+ tornadoes also are analyzed. It is found that (i) at the time of their peak 0-1 km azimuthal shear, non-tornadic supercells have consistently small (< 20 km2) ZDR column areas while tornadic cases exhibit much greater variability in areas, and (ii) at the time of tornadogenesis, EF3+ tornadic cases have larger ZDR column areas than tornadic cases rated EF1/2. In addition, all nine violent tornadoes sampled have ZDR column areas > 30 km2 at the time of tornadogenesis. However, only weak positive correlation is found between ZDR column area and both radar-estimated peak tornado intensity and maximum tornado path width. Planned future work focused on mechanisms linking updraft size and tornado formation and intensity is summarized and the use of the modified TRENDSS algorithm, which is immune to ZDR bias and thus ideal for real-time operational use, is emphasized.
KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia
Authors: Arede Liliana , Foerner Elena , Wind Selinde , Kulkarni Rashmi , Domingues Ana Filipa , Giotopoulos George , Kleinwaechter Svenja , Mollenhauer-Starkl Maximilian , Davison Holly , Chandru Aditya , Asby Ryan , Samarista Ralph , Gupta Shikha , Forte Dorian , Curti Antonio , Scheer Elisabeth , Huntly Brian J. P. , Tora Laszlo , Pina Cristina 
Published: October 2021

Abstract
Epigenetic histone modifiers are key regulators of cell fate decisions in normal and malignant hematopoiesis. Their enzymatic activities are of particular significance as putative therapeutic targets in leukemia. In contrast, less is known about the contextual role in which those enzymatic activities are exercised and specifically how different macromolecular complexes configure the same enzymatic activity with distinct molecular and cellular consequences. We focus on KAT2A, a lysine acetyltransferase responsible for histone H3 lysine 9 acetylation, which we recently identified as a dependence in acute myeloid leukemia stem cells and that participates in 2 distinct macromolecular complexes: Ada two-A-containing (ATAC) and Spt-Ada-Gcn5-Acetyltransferase (SAGA). Through analysis of human cord blood hematopoietic stem cells and progenitors, and of myeloid leukemia cells, we identify unique respective contributions of the ATAC complex to regulation of biosynthetic activity in undifferentiated self-renewing cells and of the SAGA complex to stabilization or correct progression of cell type–specific programs with putative preservation of cell identity. Cell type and stage-specific dependencies on ATAC and SAGA-regulated programs explain multilevel KAT2A requirements in leukemia and in erythroid lineage specification and development. Importantly, they set a paradigm against which lineage specification and identity can be explored across developmental stem cell systems.
INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemia
Authors: Martinelli Giovanni , Papayannidis Cristina , Piciocchi Alfonso , Robustelli Valentina , Soverini Simona , Terragna Carolina , Marconi Giovanni , Lemoli Roberto M. , Guolo Fabio , Fornaro Antonella , Lunghi Monia , de Fabritiis Paolo , Candoni Anna , Selleri Carmine , Simonetti Federico , Bocchia Monica , Vitale Antonella , Frison Luca , Tedeschi Alessandra , Cuneo Antonio , Bonifacio Massimiliano , Martelli Maria Paola , D’Ardia Stefano , Trappolini Silvia , Tosi Patrizia , Galieni Piero , Fabbiano Francesco , Abbenante Maria Chiara , Granier Muriel , Zhu Zhaoyin , Wang Mingyue , Sartor Chiara , Paolini Stefania , Cavo Michele , Foà Robin , Fazi Paola , Vignetti Marco , Baccarani Michele 
Published: October 2021

AbstractTyrosine kinase inhibitors have improved survival for patients with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for old or unfit patients remains poor. In the INCB84344-201 (formerly GIMEMA LAL 1811) prospective, multicenter, phase 2 trial, we tested the efficacy and safety of ponatinib plus prednisone in newly diagnosed patients with Ph+ ALL ≥60 years, or unfit for intensive chemotherapy and stem cell transplantation. Forty-four patients received oral ponatinib 45 mg/d for 48 weeks (core phase), with prednisone tapered to 60 mg/m2/d from days-14-29. Prophylactic intrathecal chemotherapy was administered monthly. Median age was 66.5 years (range, 26-85). The primary endpoint (complete hematologic response [CHR] at 24 weeks) was reached in 38/44 patients (86.4%); complete molecular response (CMR) in 18/44 patients (40.9%) at 24 weeks. 61.4% of patients completed the core phase. As of 24 April 2020, median event-free survival was 14.31 months (95% CI 9.30-22.31). Median overall survival and duration of CHR were not reached; median duration of CMR was 11.6 months. Most common treatment-emergent adverse events (TEAEs) were rash (36.4%), asthenia (22.7%), alanine transaminase increase (15.9%), erythema (15.9%), and γ-glutamyltransferase increase (15.9%). Cardiac and vascular TEAEs occurred in 29.5% (grade ≥3, 18.2%) and 27.3% (grade ≥3, 15.9%), respectively. Dose reductions, interruptions, and discontinuations due to TEAEs occurred in 43.2%, 43.2%, and 27.3% of patients, respectively; 5 patients had fatal TEAEs. Ponatinib and prednisone showed efficacy in unfit patients with Ph+ ALL; however, a lower ponatinib dose may be more appropriate in this population. This trial was registered at www.clinicaltrials.gov as #NCT01641107.
Impact of Surface States and Aluminum Mole Fraction on Surface Potential and 2DEG in AlGaN/GaN HEMTs
Authors: Kaushik Pragyey Kumar , Singh Sankalp Kumar , Gupta Ankur , Basu Ananjan , Chang Edward Yi 
Published: October 2021

AbstractThe presence of surface traps is an important phenomenon in AlGaN/GaN HEMT. The electrical and physical properties of these surface traps have been analyzed through the study of 2DEG electron concentration along with the variation of aluminum percentage in the barrier layer of HEMT. This analysis shows that from deep to shallow donors, the percentage change in electron density in 2DEG gets saturated (near 8%) with change in aluminum concentration. The depth of the quantum potential well below the Fermi level is also analyzed and is found to get saturated (near 2%) with aluminum percentage when surface donor states energy changes to deep from shallow. The physics behind this collective effect is also analyzed through band diagram too. The effect of surface donor traps on the surface potential also has been discussed in detail. These surface states are modeled as donor states. Deep donor (EC − ED = 1.4 eV) to shallow donor (EC − ED = 0.2 eV) surface traps are thoroughly studied for the donor concentration of 1011 to 1016 cm−2. This study involves an aluminum concentration variation from 5 to 50%. This paper for the first time presents the comprehensive TCAD study of surface donor and analysis of electron concentration in the channel and 2DEG formation at AlGaN–GaN interface.