bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Critical Role of Additive Sulfate for Stable Alkaline Seawater Oxidation on Nickel‐Based Electrodes
Authors: Ma Tengfei , Xu Wenwen , Li Boran , Chen Xu , Zhao Jiajun , Wan Shusheng , Jiang Kun , Zhang Sixie , Wang Zhongfeng , Tian Ziqi , Lu Zhiyi , Chen Liang 
Published: August 2021

AbstractSeawater electrolysis to produce hydrogen is a critical technology in marine energy projects; however, the severe anode corrosion caused by the highly concentrated chloride is a key issue should be addressed. In this work, we discover that the addition of sulfate in electrolyte can effectively retard the corrosion of chloride ions to the anode. We take nickel foam as the example and observe that the addition of sulfate can greatly improve the corrosion resistance, resulting in prolonged operating stability. Theoretical simulations and in situ experiments both demonstrate that sulfate anions can be preferentially adsorbed on anode surface to form a negative charge layer, which repulses the chloride ions away from the anode by electrostatic repulsion. The repulsive effect of the adsorbed sulfate is also applicable in highly‐active catalyst (nickel iron layered double hydroxide) on nickel foam, which shows ca. 5 times stability of that in traditional electrolyte.
Synthesis of water‐soluble BODIPY dyes and investigation of their DNA interaction properties and cytotoxicity/phototoxicity
Authors: Keleş Turgut , Barut Burak , Yıldırım Sercan , Yalçın Can Özgür , Biyiklioglu Zekeriya 
Published: August 2021

AbstractIn this study, water‐soluble BODIPY dyes (BDPY‐4,BDPY‐5) bearing dimethylamino and diethylamino groups were synthesized for the first time. The DNA interaction and nuclease effect of two water‐soluble BODIPY dyes were examined using absorption, competitive binding experiments, and agarose gel electrophoresis. Then, cytotoxicity and phototoxicity of the compounds were determined against A549 cells by MTT cell viability assay. The ultraviolet–visible (UV–vis) spectra ofBDPY‐4andBDPY‐5displayed hypochromism and absorption maxima shifted to the red region. In addition,Kbvalues of the compounds were calculated as 2.23 × 104and 4.84 × 104 M−1, respectively. An high‐performance liquid chromatography (HPLC) instrument without a column was used to conduct competitive binding experiments for the first time. The approach prevented the decrease in the response due to dilution and enabled the analysis to be carried out in a short time. Upon increasing concentrations of the compounds, the emission intensity of EB‐DNA significantly decreased. These obtained results suggested that the compounds bound to CT‐DNA with intercalative mode. At the same time, the Stern–Volmer constants were determined as 1.80 × 106and 1.79 × 106 M−1forBDPY‐4andBDPY‐5, respectively, which is coherent with intercalative binding mode. The compounds did not display noticeable photonuclease actions with light irradiation.BDPY‐4andBDPY‐5showed moderate phototoxic properties on light irradiation.
A general fractional model of creep response for polymer materials: Simulation and model comparison
Authors: Gao Yunfei , Zhao Bin , Yin Deshun , Yuan Lili 
Published: August 2021

AbstractThe creep deformation of polymer materials is a major concern to ensure the safety and reliability of structural designed parts. In this work, a novel fractional creep model is established by introducing the superb Almeida‐Caputo fractional derivative into the traditional viscoelastic constitutive equation. The kernel function is determined by conducting several simulations of uniaxial creep tests, making it more flexible and reliable to provide excellent description of creep deformation. Compared to the traditional fractional model, the proposed model exhibits higher accuracy and better performance, and is found to have the ability to depict the nonlinear time‐varying characteristic at accelerated creep stage. Furthermore, the physical significance of fractional order is explored by performing the sensitivity analysis of model parameters, the results revel that the order is closely associated with the evolution of material properties where the diagrams of creep deformation of polymer materials under elevated temperature and stress levels could be mirrored by the variation of fractional order.
Rheumatoid arthritis: Development after the emergence of a chemokine for neutrophils in the synovium
Authors: Katayama Hiroshi 
Published: August 2021

AbstractRheumatoid arthritis (RA) may not be a multifactorial disease; it can be hypothesized that RA is developed through a series of events following a triggering event, which is the emergence of a chemokine for neutrophils in the synovium. IL‐17A, secreted by infiltrated neutrophils, stimulates synoviocytes to produce CCL20, which attracts various CCR6‐expressing cells, including Th17 cells. Monocytes (macrophages) appear after neutrophil infiltration according to the natural course of inflammation and secrete IL‐1β and TNFα. Then, IL‐17A, IL‐1β, and TNFα stimulate synoviocytes to produce CCL20, amplifying the inflammation. Varieties of chemokines secreted by infiltrating cells accumulate in the synovium and induce synoviocyte proliferation by binding to the corresponding G protein‐coupled receptors, thus expanding the synovial tissue. CCL20 in this tissue attracts circulating monocytes that express both CCR6 and receptor activator of NF‐κB (RANK), which differentiate into osteoclasts in the presence of RANKL. In this way, pannus is formed, and bone destruction begins.
A chemiluminescence sensor array for discrimination of seven toxicants
Authors: Zhou Ziqi , Gong Yige , Zhang Chao , Niu Weifen 
Published: August 2021

AbstractA chemiluminescence (CL) sensor array was developed based on 11 CL systems cross‐combined by three luminescence reagents and four oxidants. Using the CL sensor array, we measured seven toxicants, including morphine, ketamine, diazepam, chlorpromazine, strychnine, paraquat, and fenpropathrin, which represent psychotropic drugs, sedatives and hypnotics, rodenticides, herbicides, and insecticides, respectively. The CL response pattern or ‘fingerprints’ were obtained for a given compound on the sensor array and then discriminated through principal component analysis. The established sensor array has been applied to real‐life samples and the results showed that it possesses excellent discrimination.
Stakeholder pressure and greenhouses gas voluntary disclosures
Authors: Chithambo Lyton , Tauringana Venancio , Tingbani Ishmael , Achiro Laura 
Published: August 2021

AbstractThis paper reports managers' perceived importance of various stakeholders' pressure in their greenhouse gas (GHG) disclosure decisions. We also report on which stakeholders explain the variation in the extent of GHG disclosures. Further, evidence of how firm size moderates the relationship between some stakeholders and GHG disclosure is provided. Data were obtained through a mail survey of the United Kingdom's FTSE 100 listed firms, to which 62 firms responded. GHG disclosures within the respondents' annual reports were scored, and regression analysis was undertaken to determine if a relationship existed between actual GHG disclosures and the rating assigned to the stakeholders. The results indicate that the provider stakeholder group (shareholders, investors and community) is perceived to have the most significant influence on managers' GHG disclosure decisions, followed by government regulators, organisational (employee, customers and suppliers) stakeholders and social (competitors, NGOs and media) stakeholders, respectively. Regression results show a positive and significant relationship between perceived organisational and regulatory stakeholder pressure and actual GHG disclosures. However, the relationship between providers and social stakeholders and GHG disclosure is not significant. The findings further suggest that the relationships between organisational and regulatory pressure are moderated by firm size. The results have important implications for policymakers.
M1 macrophage‐derived exosomes aggravate bone loss in postmenopausal osteoporosis via a microRNA‐98/DUSP1/JNK axis
Authors: Yu Long , Hu Ming , Cui Xu , Bao Da , Luo Zhanpeng , Li Dawei , Li Litao , Liu Ning , Wu Yunfeng , Luo Xiaobo , Ma Yuanzheng 
Published: August 2021

AbstractMacrophages (Mφs) are master regulators of the immune response and may serve as therapeutic targets in aging societies. This study aimed to determine the function of M1Mφ‐exosomes (Exos) in the development of osteoporosis (OP) and the involvement of microRNA (miR)‐98 and dual specificity phosphatase 1 (DUSP1). A murine model of OP was established using ovariectomies (OVX). Bone loss was observed in OVX‐treated mice, as manifested by reduced bone mineral density and decreased number of bone trabecula. The bone loss was further aggravated by treatment with M1Mφ‐Exos. Exos also suppressed osteogenic differentiation of MC3T3‐E1 cells. miRNA microarray analysis revealed that the miR‐98 level was notably upregulated in cells after Exo treatment, and DUSP1 was confirmed as a target of miR‐98. Meanwhile, downregulation of miR‐98 or upregulation of DUSP1 restored the osteogenic differentiation ability of MC3T3‐E1 cells. In addition, upregulation of DUSP1 reduced bone loss in murine bone tissues and suppressed JNK phosphorylation. In summary, M1Mφ‐derived exosomal miR‐98 exacerbates bone loss and OP by downregulating DUSP1 and activating the JNK signaling pathway. miR‐98 may therefore serve as a therapeutic target in OP management.
Percutaneous atrial septal defect occlusion through thrombosed inferior vena cava filter
Authors: Rakotonoel Radotseheno Rolland , Rioufol Gilles , Uhlrich William , Derimay François 
Published: August 2021

AbstractThrombosed inferior vena cava (IVC) should not be considered as a limitation to femoral access for cardiac structural procedures. Reopening by angioplasty in the same procedural step is feasible and safe.
Usefulness of simultaneous measurement of brain and muscle regional oxygen saturation in shock patients: A report of three cases
Authors: Muratsu Arisa , Hirose Tomoya , Ohnishi Mitsuo , Tachino Jotaro , Nakao Shunichiro , Takegawa Ryosuke , Sakai Tomohiko , Shiozaki Tadahiko , Shimazu Takeshi 
Published: August 2021

AbstractThe regional oxygen saturation (rSO₂) values of brain and muscle tissues can be measured simultaneously even if blood pressure cannot be measured due to circulatory failure associated with shock and may continuously reflect the oxygen supply‐demand balance.
NCoCu Carbon Dots Intertwined NiCo Double Hydroxide Nanorod Array for Efficient Electrocatalytic Hydrogen Evolution
Authors: Jin Jie , Chen Zhiqiang , Zhang Yi , Qu Hongxia , Wan Changwu , Zhu Tenglong , Zhong Qin 
Published: August 2021

AbstractElectrocatalytic production of hydrogen from water is a faster and environmentally friendly way of producing bulk hydrogen with the highest purity. Herein, a highly efficient mesh‐like cobalt hydroxide self‐supporting catalyst coupled with NCoCu‐5 carbon dots (CDs) on Ni foam (NF) is reported by a common hydrothermal way. The type of carbon dots on NiCo double hydroxide has a great effect on the morphology of the catalyst (NCoCu‐5 CDs/NF−CoNi). The intertwined mesh‐like NCoCu‐5 CDs/NF−CoNi catalyst has an excellent HER performance, exhibiting a low overpotential of 65 mV at 10 mA cm−2. After coupling with NCoCu‐5 CDs, a new Co−N electronic transfer channel is created in composite, and a suitable electronic environment is produced between Co and NCoCu‐5 CDs. Copper cations react with NF to generate Cu+ intermediate ions, thus further promoting the formation of Co3+. It supplies a high‐speed charge channel for the transmission of ions and increases the active sites.
Unveiling Organocatalysts Action – Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology
Authors: Westphal Hannes , Warias Rico , Becker Holger , Spanka Matthias , Ragno Daniele , Gläser Roger , Schneider Christoph , Massi Alessandro , Belder Detlev 
Published: August 2021

AbstractThis paper reports a new method for studying stereoselective catalyzed reactions at a small scale. For this purpose, a micro‐sized chemical reactor and a chiral chromatographic column were integrated on a single microfluidic chip hyphenated to mass spectrometry. By running the integrated reactor in truly continuous‐flow operation with an automated injection strategy, catalytic processes and their stereoselectivity can be observed over an extended range of time with significantly small consumption of samples, solvents, and catalytic material.
The Dual Effect of Coordinating −NH Groups and Light in the Electrochemical CO2 Reduction with Pyridylamino Co Complexes
Authors: Fernández Sergio , Cañellas Santiago , Franco Federico , Luis Josep M. , Pericàs Miquel À. , Lloret‐Fillol Julio 
Published: August 2021

AbstractCO2 electroreduction could be improved by applying conceptualized strategies to overcome catalytic bottlenecks. In this regard, we report two new cobalt(II) complexes [Co(Py2RN3)(OTf)](OTf) (CoR, R=H, Me) based on a new C2‐symmetric pentacoordinate chiral ligand that are active on the electrochemical CO2 reduction to CO. One of the complexes has a N−H group oriented towards the CO2 binding site (CoH), while the other has a N−Me group with the same orientation (CoMe), as showed by X‐ray diffraction. We have studied the effect of introducing hydrogen bonding sites, i. e. N−H in CoH, as a strategy to stabilize reaction intermediates. The complex bearing coordinating unprotected N−H group (CoH) displays catalytic CO2 reduction at the CoII/I redox potential (−1.9 V vs. Fc, ca. 40 % FYCO) whereas CoMe shows CO2 reduction at the CoI/0 redox pair. FTIR‐SEC and DFT calculations identified a [CoI−CO]+ cation as catalytic intermediate. The beneficial effect of the N−H group has been attributed to the stabilization of reaction intermediates or transition states and by the larger electron‐donating capacity, thus enhancing the nucleophilic character of the CoI intermediate. The study also points to the CO dissociation from the Co(I)−CO resting state intermediate as one of the bottlenecks of the catalytic cycle, which can be overcome with light irradiation, resulting in an increase of the total CO production (−1.9 V, 81 % FYCO, 11.2 TONCO) at the CoII/I redox potential.
Investigating the Effect of the Initial Valence States of Copper on CO2 Electroreduction
Authors: Wu Minfang , Dong Xiao , Chen Wei , Chen Aohui , Zhu Chang , Feng Guanghui , Li Guihua , Song Yanfang , Wei Wei , Sun Yuhan 
Published: August 2021

AbstractAbstract: The valence states of copper always play an important role for the most studied copper‐based catalysts in CO2 electroreduction (CO2ERR). In this work, distinct Cu, Cu2O, and CuO nanoparticles with similar particle size on active carbon are synthesized via carbonthermal reduction. Although all CuOx nanoparticles are reduced to metallic Cu during CO2ERR, their different initial valence states result in particle‐size variations and different CO2ERR performances. Cu nanoparticles in Cu/C evolve into smaller particles, while those derived from Cu2O/C and CuO/C agglomerate into larger ones. The optimal CO production potential of CO drops with decreasing particle size and is as low as −0.7 V (vs. the eversible hydrogen electrode) on Cu/C. Furthermore, Cu nanoparticles in Cu/C expose much more active sites with higher electrochemical active area and stronger CO adsorption, which further promote C−C coupling to produce C2+ products while inhibiting competitive hydrogen evolution.
Effect of Arylmethylene Substitutions on Molecular Structure, Optoelectronic Properties and Photovoltaic Performance of Dithienocyclopentafluorene‐Based Small‐Molecule Acceptors
Authors: Tang Xuejiao , Liao Haitao , Zheng Tao , Yin Pan , Cao Jing , Zeng Xiaoying , Weng Chao , Shen Ping 
Published: August 2021

AbstractTwo dithienocyclopentafluorene‐based small‐molecule acceptors (SMAs) were developed that feature methylene‐functionalized conjugated side chains, to study the effect of arylmethylene substitution and its number on structure, optoelectronic properties and device performance. Results showed that two SMAs have better absorption properties and planarity, lower bandgaps and higher LUMOs compared with the control SMA without conjugated side chains. The synthesized SMAs were tested in polymer solar cells for examples of their applicability. This work argues that the introduction of methylene‐functionalized conjugated side chains has great potential in tuning molecular structure, optoelectronic properties, device physics and photovoltaic performance of SMAs.
C4’‐Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies
Authors: Zhou Yifei , Lu Kuan , Li Qiang , Fan Chaochao , Zhou Chuanzheng 
Published: August 2021

AbstractFluoro‐substitution on the ribose moiety (e. g., 2’‐F‐deoxyribonucleotide) represents a popular way to modulate the ribose conformation and, hence, the structure and function of nucleic acids. In the present study, we synthesized 4’‐F‐deoxythymidine (4’‐FT) and introduced it to oligodeoxyribonucleotides (ODNs). Though scission of the glycosylic bond of 4’‐FT followed by strand cleavage occurred to some extent under alkaline conditions, the 4’‐FT‐modified ODNs were rather stable in neutral buffers. NMR studies showed that like 2’‐F‐deoxyribonucleoside, 4’‐FT exists predominantly in the North conformation not only in the nucleoside form but also in the context of ODN strands. Circular dichroism spectroscopy, thermal denaturing and RNase H1 footprinting studies of 4’‐FT‐modified ODN/cDNA and ODN/cRNA duplexes indicated that the North conformation tendency of 4’‐FT is maintained in the duplexes, leading to a local structural perturbation. Collectively, 4’‐F‐deoxyribonucleotide structurally resembles the 2’‐F‐deoxyribonucleotide but imparts less structural perturbation to the duplex than the latter.
Elevated serum lipoprotein(a) is significantly associated with angiographic progression of coronary artery disease
Authors: Shui Xing , Wen Zheqi , Chen Zefeng , Xie Xujing , Wu Yongxia , Zheng Binghan , Wu Zhen , Chen Lin 
Published: August 2021

AbstractBackgroundLipoprotein(a)[Lp(a)] has been considered as an independent risk factor for coronary artery disease (CAD). The present study aimed to evaluate the association between baseline serum Lp(a) and CAD progression determined by angiographic score.MethodsA total of 814 patients who had undergone two or more coronary computed tomography angiography at least 6 months apart were consecutively enrolled and the coronary severity was determined by the Gensini score system. Patients were stratified into two groups according to Lp(a)>300 mg/L and Lp(a) ≤ 300 mg/L or classified as “progressors” and “non‐progressors” based on the Gensini score rate of change per year. The association of continuous Lp(a) and Lp(a)>300 mg/L with CAD progression were respectively assessed by logistic regression analysis. Moreover, further evaluation of those association was performed in subgroups of the study population.ResultsPatients in the “progressors” group had significant higher Lp(a) levels. Furthermore, the multivariate logistic regression analysis showed that elevated Lp(a) (odds ratio [OR]: 1.451, 95% confidence interval [CI]: 1.177–1.789, p<.001) and Lp(a)>300 mg/L (OR:1.642, 95% CI:1.018–2.649, p = .042) were positively associated with CAD progression after adjusting for confounding factors. In addition, those relation seemed to be more prominent in subjects with lower body mass index (OR: 1.880, 95% CI: 1.224–2.888, p for interaction = .060).ConclusionsElevated baseline serum Lp(a) is positively and independently associated with angiographic progression of CAD, particularly in participants with relatively low body mass index. Therefore, Lp(a) could be a potent risk factor for CAD progression, assisting in early risk stratification in cardiovascular patients.
Usefulness of a novel transarterial chemoinfusion plus external‐beam radiation therapy for advanced hepatocellular carcinoma with tumor thrombi in the inferior vena cava and right atrium: Case study
Authors: Shirono Tomotake , Koga Hironori , Niizeki Takashi , Nagamatsu Hiroaki , Iwamoto Hideki , Shimose Shigeo , Nakano Masahito , Okamura Shusuke , Noda Yu , Kamachi Naoki , Kuromatsu Ryoko , Ogo Etsuyo , Torimura Takuji 
Published: August 2021

AbstractBackgroundInvasion beyond inferior vena cava (IVC) to right atrium (RA) is a rare complication in patients with advanced hepatocellular carcinoma (HCC), and results in fatal oncologic emergencies, including pulmonary embolism and right heart failure.AimAs there is no gold standard treatment for unresectable HCC with tumor thrombi involving IVC and RA, we considered it valuable to assess safety and efficacy of a combination of hepatic arterial infusion chemoembolization (HAIC) therapy and external‐beam radiation therapy (EBRT).Methods and resultsThe “New FP” was chosen as the HAIC therapy, in which the enhanced permeation and retention effect was achieved using a cisplatin‐Lipiodol suspension combined with continuous infusion of 5‐fluorouracil (5‐FU). Sixteen patients with HCC with tumor thrombi in IVC, RA, and pulmonary arteries were enrolled. modified response evaluation criteria in solid tumors‐based evaluation of response to the combination treatment was as follows: complete response, 6.2% (1 patient); partial response, 81.3% (13 patients); stable disease, 12.5% (2 patients); progressive disease, 0%. The median overall survival time (MST) was 19.0 months. Notably, MST of patients receiving sequential sorafenib monotherapy (39.0 months) was significantly longer than that of the rest (15.3 months).ConclusionThe combination of New FP and EBRT is an efficacious treatment option for unresectable HCC involving IVC and RA, complicated with pulmonary embolism. Sequential administration of molecular‐targeted drugs may prolong survival in such patients.
A parallel hash‐based method for local sequence alignment
Authors: Esmat Aghaee‐Meybodi , Amin Nezarat , Sima Emadi , Reza Ghaffari Mohammad 
Published: August 2021

SummaryAlgorithms utilize an index‐based aligning strategy, like a hash table, which typically entails the seed‐and‐extend method and is a time‐consuming task. Here, we developed a hash‐based search algorithm based on the SSAHA method without the use of seed‐and‐extend to conduct search and alignment faster than previous methods with multiple processors. In the proposed method by using the overlapping method in query and reference sequences, the accuracy and sensitivity increased. Further, the speed also increased by creating a hash table for the reference sequence when it was placed in the memory. Furthermore, by evaluating three datasets of different sequences in size and volumes, the effect of the created piece lengths as well as the effect of multiple processors on each dataset was evaluated indicating not only appeasing the time issue in alignment but also improving the mapping speed compared to the BLAST and SSAHA algorithms.