bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis
Authors: Kaaij Merlijn H , Rip Jasper , Jeucken Kim C M , Kan Yik Y , van Rooijen Charlotte C N , Saris Job , Pots Desiree , Frey Silke , Grootjans Joep , Schett Georg , van Duivenvoorde Leonie M , Nolte Martijn A , Hendriks Rudi W , Corneth Odilia B J , van Hamburg Jan Piet , Baeten Dominique L P , Tas Sander W 
Published: September 2021

Abstract
TNF is important in immune-mediated inflammatory diseases, including spondyloarthritis (SpA). Transgenic (tg) mice overexpressing transmembrane TNF (tmTNF) develop features resembling human SpA. Furthermore, both tmTNF tg mice and SpA patients develop ectopic lymphoid aggregates, but it is unclear whether these contribute to pathology. Therefore, we characterized the lymphoid aggregates in detail and studied potential alterations in the B and T cell lineage in tmTNF tg mice. Lymphoid aggregates developed in bone marrow (BM) of vertebrae and near the ankle joints prior to the first SpA features and displayed characteristics of ectopic lymphoid structures (ELS) including presence of B cells, T cells, germinal centers, and high endothelial venules. Detailed flow cytometric analyses demonstrated more germinal center B cells with increased CD80 and CD86 expression, along with significantly more T follicular helper, T follicular regulatory, and T regulatory cells in tmTNF tg BM compared with non-tg controls. Furthermore, tmTNF tg mice exhibited increased IgA serum levels and significantly more IgA+ plasma cells in the BM, whereas IgA+ plasma cells in the gut were not significantly increased. In tmTNF tg × TNF-RI−/− mice, ELS were absent, consistent with reduced disease symptoms, whereas in tmTNF tg × TNF-RII−/− mice, ELS and clinical symptoms were still present. Collectively, these data show that tmTNF overexpression in mice results in osteitis and ELS formation in BM, which may account for the increased serum IgA levels that are also observed in human SpA. These effects are mainly dependent on TNF-RI signaling and may underlie important aspects of SpA pathology.
Singquandle shadows and singular knot invariants
Authors: Ceniceros Jose , Churchill Indu R. , Elhamdadi Mohamed 
Published: September 2021

AbstractWe introduce shadow structures for singular knot theory. Precisely, we define two invariants of singular knots and links. First, we introduce a notion of action of a singquandle on a set to define a shadow counting invariant of singular links which generalize the classical shadow colorings of knots by quandles. We then define a shadow polynomial invariant for shadow structures. Lastly, we enhance the shadow counting invariant by combining both the shadow counting invariant and the shadow polynomial invariant. Explicit examples of computations are given.
Analysis of Teaching Reform of Harmony Teaching in Chinese Normal Colleges and Universities
Authors: Li Yan 
Published: September 2021

"Harmony" course plays a very important role in the talent training system of Normal universities and colleges in China. In order to continuously improve the teaching quality of the Harmony Course, many predecessors and colleagues have made great efforts. This paper briefly analyzes the reform of harmony teaching in the past 40 years, both from the existing achievements and the existing problems.
Muhammad's Body
Authors: Knight Michael Muhammad 
Published: September 2021

Muhammad’s Body introduces questions of embodiment and materiality to the study of the Prophet Muhammad. Analyzing classical Muslim literary representations of Muhammad’s body as they emerge in Sunni hadith and sira from the eighth through the eleventh centuries CE, Michael Muhammad Knight argues that early Muslims’ theories and imaginings about Muhammad’s body contributed in significant ways to the construction of prophetic masculinity and authority.
Knight approaches hadith and sira as important religiocultural and literary phenomena in their own right. In rich detail, he lays out the variety of ways that early believers imagined Muhammad’s relationship to beneficent energy—baraka—and to its boundaries, effects, and limits. Drawing on insights from contemporary theory about the body, Knight shows how changing representations of the Prophet’s body helped to legitimatize certain types of people or individuals as religious authorities, while marginalizing or delegitimizing others. For some Sunni Muslims, Knight concludes, claims of religious authority today remain connected to ideas about Muhammad’s body.
A Pilot Study of the Effect of Otago Exercise Program on Fall Risk and Quality of Life of Older Women
Authors: Kadir Muammar Irsyad , Hardiyanty Nur , Adliah Fadhia 
Published: September 2021

Objective: This study aims to determine the effect of the Otago Exercise Program on the risk of falling and the quality of life of older people.
Methods: The method used was experimental research with pretest-posttest design and control group design, involving 16 participants. Before and after treatment, respondents measured the risk of falling using a Timed-Up-and-Go test (TUGT) and quality of life using the World Health Organization Quality of Life BREF (WHOQL-BREF). Furthermore, the obtained data were analyzed using the paired T-test and independent T-test.
Results: The results showed a significant effect on the risk of fall and the quality of life of the older people in the treatment group. In addition, there were significant different influences on the value of falling risk and quality of life (physical and environmental) between the treatment and control groups.
Conclusion: The Otago exercise program had a significant effect on reducing the risk of falls and improving the quality of life of older people.
Ergonomic Intervention on Physical Therapy Programs Decrease Pain and Disability Level on Subject with Myogenic Low Back Pain: A Case Report
Authors: Prianthara I Made Dhita , Suadnyana Ida Ayu Astiti , Suparwati Komang Tri Adi , Marufa Siti Ainun 
Published: September 2021

Introduction: Myogenic Low Back Pain is an uncomfortable pain on the lower back, often caused by musculoskeletal disorders resulting in pain and disability. This case report aims to review ergonomic intervention on physical therapy program on myogenic low back pain.
Case description: A 45-years-old man working as a roof tile craftsman complained of pain in the lower back area and already felt it for 1 month ago. The pain did not radiate to the leg. The patient has no neurological signs and symptoms. Patient-reported that he had experienced the same incident about 9 times in the last 3 years ago. The patient always performed bending motion and lifting the roof tile every day. The patient has been visited physical therapy and received ergonomic intervention and physical therapy programs such as core stability exercise, soft tissue mobilization and modalities for seven weeks. Following the ergonomic intervention and therapeutic exercise application, the Visual Analogue Scale score decreased from 6 to 0. The Modified Oswestry Disability Index score gradually decreased from 60% disability to 0% disability. The patient no longer complained of MLBP and was able to lift the roof tile well.
Conclusion: After a seven-weeks physical therapy treatment session, the patient did not feel pain and can perform forward bending. Modified Oswestry Disability Index score improved and demonstrated improved lifting the roof tile without any complaints. We concluded that the ergonomic intervention combined with physical therapy programs effectively decreased pain and disability level on a subject with MLBP
Exercise Program in Post-Surgical Release of Knee Flexion Contracture in Patient with Osteochondroma: A Case Report
Authors: Motik Deva Natalia , Kurniawati Ida 
Published: September 2021

Introduction: Knee flexion contracture is caused by adaptive shortening of the muscles which is marked by the incapability of the knee to fully extend. This condition is associated with long periods of immobilization, pain, and muscle weakness that are caused by various pathological conditions. Post-surgical rehabilitation program is mainly aimed to recover basic lower limb functions through an exercise program.
Case description: A 16-year-old male patient with a history of left-sided knee pain and fixed flexion contracture was undergone a surgical release procedure and diagnosed with osteochondroma. Post-surgical evaluation by physical therapist found muscle atrophy, limited range of motion, and pain on the operated limb. The patient was instructed to do muscle strengthening and active exercise on both legs. Exercise program post-surgery aimed to improve muscle strength, range of motion, functional limb ability and activities of daily living. Improvement in the range of motion of the left knee joint was observed after three sessions of physical therapy intervention.
Conclusion: Exercise program could reduce the muscle contracture and improve the knee joint range of motion in patients with osteochondroma following surgical release procedure.
Teaching writing as public work: John Macmillan Brown and ‘practical’ composition
Authors: Gerrard Hannah 
Published: September 2021

John Macmillan Brown, Professor of Classics and English at Canterbury College, was one of the first teachers of writing in a New Zealand university. Here I examine how his composition pedagogy offers a relationship between English instruction, academic success, and professional and public life, which remains relevant and provocative today. I suggest that the move away from Macmillan Brown’s pedagogy can be located in a history of student writing in the New Zealand university and its increasing marginalisation, as a result of limited teaching resources and the challenge of instituting a liberal arts model for university education. Acknowledging the complexity of Macmillan Brown’s ‘practical’ pedagogical project, I also suggest that attention to such teaching might put pressure on histories of the university that prioritise the development of research capacity, and can serve to denaturalise and explain some of our present-day assumptions about the teaching of writing and literacy in the university
‘I don’t think we’re seen as a nuisance’: the positioning of postgraduate learning advisors in New Zealand universities
Authors: Strauss Pat 
Published: September 2021

New Zealand universities host linguistically and culturally diverse cohorts of students. Many of these students, both first and second language speakers of English, struggle to achieve their potential because their academic language skills do not meet the requirements of the academy. Despite the acknowledged need to facilitate the improvement of all students’ language skills, in particular the ability to write clearly and cogently, the learning advisors at each university who are tasked with assisting this development are, on the whole, not held is in high esteem by the institutions they serve. This lack of regard makes it difficult for them to be effective in helping students reach their full potential. This article sought to capture the perspectives of postgraduate learning advisors at universities around New Zealand, which might have relevance for those based elsewhere. It concludes with some suggestions as to how advisors might strengthen their position and gain recognition for the contribution they make in the postgraduate sector.
Zur Frage der Tempi in den Orgelwerken Felix Mendelssohn Bartholdys
Authors: Wind Burkhard 
Published: September 2021

Mendelssohn versah seine sechs Orgelsonaten op. 65 mit Metronomangaben und lieferte damit aufschlussreiches Informationsmaterial bezüglich seiner auf die Orgel bezogenen Tempoauffassung. Alle anderen Orgelwerke sind dagegen vom Komponisten nicht metronomisiert worden. Bei der Wahl eines angemessenen Tempos für die Orgelwerke Mendelssohns ohne Metronomangaben folgt aus der vorhandenen Instrumentenspezifik des Tempos die besondere Autorität der Angaben aus den Sonaten op. 65 - sie sind am ehesten geeignet, Anhaltspunkte zu liefern. Ein Vergleich der Auffassungen von Friedrich Wilhelm Schütze und Johann Nepomuk Hummel sowie Adolf Bernhard Marx auf der einen Seite und Mendelssohns Angaben in op. 65 auf der anderen zeigt, dass sich Mendelssohns Metronomangaben in einem durchaus zeittypischen Rahmen bewegen.
bms online (Cornelia Schöntube)
Franz Schuberts 20 Ländler D 366 / D 814 - nicht bearbeitet von Johannes Brahms
Authors: Behr Johannes 
Published: September 2021

Im Jahr 1869 erschienen bei J.P. Gotthard in Wien 20 nachgelassene Ländler Franz Schuberts in zwei separaten Ausgaben für Klavier zu zwei bzw. zu vier Händen. Vier der zweihändigen und 16 der vierhändigen publizierten Ländler sind fremde Arrangements. Es lässt sich zeigen, dass diese Bearbeitungen nicht von Johannes Brahms stammen wie bisher angenommen, sondern vom Verleger J. P. Gotthard für die von ihm veröffentlichten Editionen angefertigt wurden. Im Jahr 1934 gab Georg Kinsky elf der im Original zweihändigen Ländler (D 366/1-6, 8-10, 12, 13) in vierhändigen, mit Gotthards Fassungen nicht identischen Bearbeitungen heraus, die er ebenfalls Brahms zuschrieb. Diese könnten von Hermann Levi stammen.
bms online (Cornelia Schöntube)
"... ein jüngerer Gelehrter von Rang"
Authors: Marx Hans Joachim 
Published: September 2021

Nach der Skizzierung der Anfänge seiner Studien wird nach Schrades wissenschaftlichem Werdegang gefragt, der für die Entwicklung des Faches Musikwissenschaft zwischen den beiden Weltkriegen in mancher Hinsicht symptomatisch ist.
bms online (Cornelia Schöntube)
Louis Spohr und der Kinnhalter
Authors: Goldbach Karl Traugott 
Published: September 2021

Der von ihm erfundene Kinnhalter oder die Kinnstütze wurde von Louis Spohr 1833 in seiner "Violinschule" noch Geigenhalter genannt. Genaue Maße wie auch ein originaler Kinnhalter Spohrs sind derzeit nicht nachweisbar. Unter anderem durch enge Verbindungen zum Geigenbauer Joseph Schonger geriet Spohr schon um 1900 als Erfinder des Kinnhalters in Vergessenheit. Dennoch verbreitete sich die Kinnstütze und war zu Beginn des 20. Jahrhunderts offenbar etabliert.
bms online (Cornelia Schöntube)
Vergangenheit in der Zukunftsmusik der Gegenwart
Authors: Herzfeld-Schild Marie Louise 
Published: September 2021

Iannis Xenakis schrieb seinen Beitrag "Epiphanien" im Jahr 1968 im Rahmen von Wolfgang Wagners Umfrage anlässlich des 100jährigen Jubiläums der "Meistersinger von Nürnberg". Er formuliert in diesem Text Gedanken zur Position von Kunst und von Musiktheater im Besonderen - zwischen Vergangenheit, Gegenwart und Zukunft. Im ersten Teil drückt sich eine Wertschätzung aus, die Xenakis dem "normgebenden Werk" ganz offensichtlich entgegenbrachte. Im zweiten Teil wird jedoch auch die Zwiespältigkeit deutlich, mit der er das Schaffen des Älteren betrachtete.
bms online (Cornelia Schöntube)
"[...] ohne noch in der musikalischen Welt besonders bekant zu sein [...]
Authors: Kuchersky Mikhail 
Published: September 2021

Im Bestand der "Acta musicalia" (AM) in Budapest ließ sich ein Brief E.T.A.Hoffmanns finden, der allem Anschein nach das bisher gesuchte Begleitschreiben ist, welches am 16.1.1812 die zweite, kalligraphisch ausgeführte Abschrift des "Miserere" für Fürst Nikolaus II. Esterházy begleitete und das Stück bewarb.
Abstract: bms online, Cornelia Schöntube
Hegel's Speculative Sentence
Authors: Haas Andrew 
Published: September 2021

ABSTRACT
Almost all philosophers (and many non-philosophers) recognize the fundamental importance of the Phenomenology of Spirit. But Hegel's way of thinking and speaking—which he names, “speculative”—needs explaining. The example of “the speculative sentence” is helpful—for here, speculating means implying, that is, neither bringing meaning to presence nor keeping it in absence; but rather, speaking and thinking by implication. If the history of philosophy, however, overlooks what is implied, then it cannot grasp what is, and what is thought and said in the speculative sentence. Luckily, there is another way: implying that which can neither be said nor left unsaid, neither thought nor unthought. Reinterpreting Hegel's speculative sentence, therefore, for implication, for what is implied—and neither present nor absent—Haas demonstrates how to think and speak speculatively about thinking and speaking, substance and subject, being and becoming, whether in philosophy or not, even if we implicate ourselves thereby.
Derecho internacional público y derecho internacional De derechos humanos. Análisis interdisciplinar
Authors: Isaac Torres Manrique Jorge 
Published: September 2021

Este artículo busca analizar, a través de un enfoque interdisciplinario, la relación entre el derecho internacional público y el derecho internacional de los derechos humanos. A partir de la especificación del concepto de derecho internacional público y de la definición de su finalidad esencial, esta investigación planifica conocer el origen y las fuentes del derecho internacional de los derechos humanos como producto de la barbarie. Siendo cierto que el derecho internacional de los derechos humanos se origina como un desdoblamiento del derecho internacional público, se concluye que el primero actúa con base en el segundo en vista del punto común a las ramas que son los derechos fundamentales.
Palabras clave: Derecho público. Derechos fundamentales. Derechos humanos
Concomitant Ceftriaxone and Intravenous Calcium Therapy in Infants
Authors: Christensen Michael L. , Zareie Parya , Kadiyala Bhavya , Bursac Zoran , Reed Michael D. , Mattison Donald R. , Davis Robert L. 
Published: September 2021

OBJECTIVE
To determine if increased mortality could be detected with the administration of ceftriaxone and IV calcium in infants through an analysis of a large repository of electronic health records.

METHODS
Patients were split into 3 groups: 1) neonates, 2) infants, and 3) infants &lt;1 year whose age was not specified. Deaths were classified into mutually exclusive categories based on the administration and timing of ceftriaxone and IV calcium. Crude death rates were calculated, and logistic regression modeling was used to calculate adjusted relative odds of death with associated covariates.

RESULTS
A total of 259,149 infants were identified. Of 79,038 neonates, the proportion of patients that received ceftriaxone and IV calcium within 48 hours who died was 3.8%, compared with 1.95% (IV calcium), 0.3% (ceftriaxone), 1.54% (IV fluids), and 2.03% (parenteral nutrition). For 102,456 infants, the proportions of deaths were 5.47% (ceftriaxone and IV calcium within 48 hours), 0.45% (IV calcium), 0.15% (ceftriaxone), 0.39% (IV fluids), and 5.5% (parenteral nutrition). Multivariate analysis showed increased odds of death in infants who received ceftriaxone and IV calcium within 48 hours, regardless of age, and propensity score–matched analysis showed a more than 2-fold increased risk for death.

CONCLUSIONS
The increased risk for death following ceftriaxone and IV calcium administration was noted not only in neonates, but among older infants as well.
Optimization of Vancomycin Dosing to Achieve Target Area Under the Curve in Pediatrics
Authors: Bosley Tyler E. , Kuhn Robert J. , Gardner Brian , Autry Elizabeth B. , Fuller Madeline , Overley Colleen L. 
Published: September 2021

OBJECTIVE
Vancomycin dosing requirements to achieve a target area under curve/minimum inhibitory concentration (AUC/MIC) of 400 to 600 mg•hr/L have not been established in pediatrics. Dose modeling studies and recent guidelines suggest dosing higher than historical recommendations. This study examines dosing requirements to achieve target AUC/MIC in human pediatric patients.

METHODS
This retrospective study includes 77 patients, aged 1 month to 18 years, at a single center, who received at least 2 days of intravenous vancomycin with a pharmacokinetic monitoring note and calculated AUC/MIC. Dosing to achieve target AUC/MIC was evaluated by age and indication. Nephrotoxicity was also assessed.

RESULTS
The mean dose required to achieve target AUC/MIC for all patients was 67.7 mg/kg/day. Adjusting for age, the mean dose required to achieve target AUC/MIC of 400 to 600 mg•hr/L was found to be statistically significantly different among 3 age cohorts: 1 month to 5 years, 6 to 12 years, and 13 to 18 years [F(2,74) = 15.32, p &lt; 0.001], with mean requirements of 79 ± 14.1, 65.6 ± 21.1, and 53.9 ± 17.1 mg/kg/day, respectively. Dosing requirements were also found to be statistically significantly different across indications [F(6,70) = 4.84, p &lt; 0.001]. Acute kidney injury was identified in 5 patients (6.5%).

CONCLUSIONS
The vancomycin dose required to achieve target AUC/MIC in pediatrics was significantly higher in younger pediatric patients and ranged from 53.9 to 79 mg/kg/day, confirming recent guideline recommendations. Doses can be further adjusted for indication. Nephrotoxicity rates remain low compared with historical rates with single trough monitoring.
Overlevelsestrategi for vejledere: Tag retorikken med i vejledningen
Authors: Hvass Helle , Heger Stine 
Published: September 2021

Der er ikke så meget tid til opgavevejledning længere, og samtidig efterspørger en gruppe studerende retningslinjer, feedback og gode råd som aldrig før. Erfaringer med at undervise og vejlede studerende i helt elementær retorik viser, at studerende bliver mere selvhjulpne skrivere, når de forstår 1) hvad det vil sige at være i en skriveproces 2) hvad kommunikationssituationen for en akademisk opgave er 3) at en akademisk opgave er en argumenterende tekst. Hensigten med artiklen er at give faglige vejledere et bud på, hvordan de, ved at tage retorikken med i vejledningen, kan få det lettere som vejledere. Artiklen indeholder tre studerendes tekster efterfulgt af konkrete eksempler på, hvordan man med elementær retorik kan vejlede hhv. Susanne som får skrevet alt for lidt, Karsten som skriver svært tilgængeligt og Anders som ikke kan finde den akademiske tone.There is not much time for supervising students’ writing, and at the same time some students ask for guidelines, feedback and good advice like never before. Experience with teaching and guiding students in elementary rhetoric shows that students become more independent writers when they understand 1) what it means to be in a writing process, 2) what the communication situation of an academic paper is 3) that an academic paper is an argumentative text. The objective of this article is to provide supervisors with an idea of how supervision can become easier with elementary rhetoric. The article includes three students’ texts followed by concrete example of how the elementary rhetoric can guide respectively Susanne who doesn’t get to write much, Karsten whose writing is difficult to access and Anders who needs to find the academic tone.
Hvad bekymrer nye ph.d.-stipendiater?
Authors: Kobayashi Sofie , Trolle Olga 
Published: September 2021

Ph.d.-stipendiaters bekymringer, når de går i gang med deres ph.d., kan være en barriere for deres overgang fra at være studerende til at blive selvstændige forskere. Indtil nu har forskningen inden for ph.d.-uddannelse fokuseret på de vanskeligheder, som ph.d.-stipendiaterne møder gennem deres studier. Generelt ses vejledningsforholdet og forskningsmiljøet som væsentlige faktorer for et godt forløb. Denne artikel fokusererderimod på de bekymringer, som ph.d.-stipendiater har, når de starter på deres ph.d. Gennem analysen fandt vi 20 temaer, og kvantificering af data indikerer, at de hyppigste temaer er Publicere, Kompetencer, tidsfaktoren, Projektledelse og Selvtillid. Det viser sig, at det, der bekymrer ph.d.-stipendiater i starten af deres studie, i nogen grad er noget andet end de vanskeligheder, der dukker op undervejs. Denne viden kan brugesaf vejledere, ph.d.-stipendiater og forskerskoler til at adressere ph.d.-stipendiaternes bekymringer i starten af deres studie.