bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aliasing‐free reduced field‐of‐view parallel imaging
Authors: Jia Sen , Qiu Zhilang , Zhang Lei , Wang Haifeng , Yang Gang , Liu Xin , Liang Dong , Zheng Hairong 
Published: November 2021

PurposeTo reconstruct aliasing‐free full field‐of‐view (FOV) images for reduced FOV (rFOV) parallel imaging (PI) with Cartesian and Wave sampling, which suffers from aliasing artifacts using existing PI methods.Theory and MethodsThe sensitivity encoding method (SENSE) was extended to the Soft‐SENSE models supporting multiple‐set coil sensitivity maps (CSM) and point spread functions (PSF) for Cartesian and Wave sampled rFOV PI, respectively. The multiple‐set CSM and PSF were created from full FOV CSM and PSF according to the image folding process induced by rFOV sampling. The Soft‐SENSE reconstructions could be solved by the same algorithms for the conventional full FOV SENSE reconstruction.ResultsSoft‐SENSE using multiple‐set full FOV CSM and PSF successfully reconstruct aliasing‐free full FOV image from rFOV PI data with Cartesian and Wave sampling. The proposed rFOV PI enables flexible control of the aliasing and achieves comparable geometry factors as the standard full FOV PI with the same net acceleration factor. Reduced FOV PI improves the computational efficiency of iterative compressed sensing (CS) and PI reconstruction, especially for high‐resolution volumetric imaging, thanks to the reduced fast Fourier transform (FFT) size. Moreover, rFOV PI reconstruction provides a potential alternative to the phase oversampling for the FOV aliasing problem.ConclusionThe proposed Soft‐SENSE using full FOV CSM and PSF could reconstruct aliasing‐free full FOV image for rFOV PI, and make it a viable solution enabling more flexible PI acceleration and effectively improving the computational efficiency of iterative CSPI reconstruction.
Simultaneous T1‐weighted and T2‐weighted 3D MRI using RF phase‐modulated gradient echo imaging
Authors: Tamada Daiki , Field Aaron S. , Reeder Scott B. 
Published: November 2021

PurposeT1‐weighted and T2‐weighted (T1w and T2w) imaging are essential sequences in routine clinical practice to detect and characterize a wide variety of pathologies. Many approaches have been proposed to obtain T1w and T2w contrast, although many challenges still remain, including long acquisition time and limitations that favor 2D imaging. In this study, we propose a novel method for simultaneous T1w and T2w imaging using RF phase‐modulated 3D gradient‐echo imaging.TheoryConfiguration theory is used to derive closed‐form equations for the steady state of RF phase‐modulated gradient‐echo signal. These equations suggest the use of small RF phase increments to provide orthogonal signal contrast with T2w and T1w in the real and imaginary components, respectively. Background phase can be removed using a two‐pass acquisition with opposite RF phase increments.MethodsSimulation and phantom experiments were performed to validate our proposed method. Volunteer images of the brain and knee were acquired to demonstrate the clinical feasibility. The proposed method was compared with T1w and T2w fast spin‐echo imaging.ResultsThe relative signal intensity of images acquired using the proposed method agreed closely with simulations and fast spin‐echo imaging in phantoms. Images from volunteer imaging showed very similar contrast compared to conventional fast spin‐echo imaging.ConclusionRadiofrequency phase‐modulated gradient‐echo with small RF phase increments is an alternative method that provides simultaneous T1w and T2w contrast in short scan times with 3D volumetric coverage.
Assessment of the effect of colored beverage on gastric returns after gastric tube replacement to enhance placement verification
Authors: McGinnis Carol , Marroquin Sara , Reed Valerie 
Published: November 2021

AbstractBackgroundVerification of appropriate placement of newly replaced gastrostomy tubes is essential prior to use to avoid potentially serious adverse events.ProblemA lack of standardized guidance regarding effective and practical means to verify placement exists. Aspiration or drainage of gastric‐like contents is one mean suggested to help determine placement, yet when returns are minimal, this becomes challenging.Materials, Method, InterventionOral ingestion or the instillation of a colored beverage prior to tube replacement was used in a midwestern healthcare clinical setting to enhance returns in both volume and color via the newly replaced gastrostomy tube. A retrospective review of this practice was conducted, which included 176 gastric tube replacements over 4 years.ResultsA significant increase in volume of returns via the newly replaced tube was noted (P < .001) and a strong correlation of color to the ingested or consumed beverage was found with 95% of returns reflecting color tinting of the beverage or in many cases, strong color change to that of the beverage color.ConclusionPresented is a simple, cost‐effective method that has shown to be clinically useful in assessing placement of newly replaced gastrostomy tubes that may be useful in other practices and settings.
Family caregivers' advocacy in voluntary stopping of eating and drinking: A holistic multiple case study
Authors: Eppel‐Meichlinger Jasmin , Stängle Sabrina , Mayer Hanna , Fringer André 
Published: November 2021

AbstractAimTo gain insight into the experiences of family caregivers who accompanied a loved one during voluntary stopping of eating and drinking and to identify similarities and differences between cases of voluntary stopping of eating and drinking to develop a conceptual model.DesignA qualitative holistic multiple case study.MethodsWe conducted narrative interviews with family caregivers (N = 17). We first analysed them inductively within the cases, followed by a cross‐case analysis to merge the experiences into a conceptual model.ResultsFamily caregivers who could accept their loved one's wish to die stood up for the last will, especially when the cognitive abilities declined. They had to take on the role of an advocate to protect their self‐determination from others who tried to interrupt the process. In their advocacy, they found themselves constantly in moral discrepancies. Usually without support, they provided nursing care until death. The subsequent processing phase was characterized by evaluating the dying situation and placing voluntary stopping of eating and drinking in their value scheme.
Multi‐verse optimizer based PI‐type active disturbance rejection generalized predictive control parameter tuning for ship motion
Authors: Ren Jia , Chen Zengqiang , Sun Mingwei , Sun Qinglin 
Published: November 2021

AbstractThe motion control of ships is the crucial of the transportation industry. The ship is an under‐actuated system with large inertia and nonlinearity, it also will be influenced by various interference during the voyaging. This work proposed a multi‐verse optimizer (MVO) tuned PI‐type active disturbance rejection generalized predictive control (PI‐ADRGPC) method. The PI‐ADRGPC is used to control the ship motion, and the MVO is employed to tune the parameters of PI‐ADRGPC. To verify the performance of the proposed method, a set of simulations with different interference are tested. The results indicate that compared with particle swarm optimization, dragonfly algorithm and moth‐flame optimization, the MVO tuned PI‐ADRGPC has better performance under different interference in the ship motion control. The Monte Carlo test also indicates that the robustness of the system is strong.
Temperature‐Controlled Conversion of Boc‐Protected Methylene Blue: Advancing Solid‐State Time‐Temperature Indicators
Authors: Merkes Jean Michel , Banala Srinivas 
Published: November 2021

AbstractCold‐chain management is of high importance in preserving perishable products and in retaining quality. A visible marker on packages indicating complete maintenance of the cold chain assures safe consumption of products by end‐users and assists in reducing waste. Time‐temperature indicators (TTIs) are integrated markers that provide information about exposure of packages to adverse temperature and have been gaining increased attention by consumers. Here we present a methylene‐blue‐based derivative, N,N,N′,N′‐tetramethyl‐N10‐Boc‐phenothiazine‐3,7‐diamine (BocPTDA), that can be used as a solid‐state organic TTI dye, exhibiting an irreversible change from colorless to blue green upon heating. The conversion properties, studied using a silicagel‐coated plate, confirmed that BocPTDA undergoes a color change above 20 °C. At temperatures of 4 °C and below, no visible changes are exhibited, making BocPTDA a well‐suited marker for monitoring abrupt temperature deviations indicating improper cold‐chain management. Thus, application of BocPTDA‐based TTI systems on packages could inform consumers about the cold‐chain maintenance, assuring quality and safe consumption.
EM‐based likelihood inference for one‐shot device test data under log‐normal lifetimes and the optimal design of a CSALT plan
Authors: Balakrishnan Narayanaswamy , Castilla Elena 
Published: November 2021

AbstractOne‐shot devices result in an extreme case of interval censoring, wherein one can only know whether the failure time is either before or after the test time. The study of one‐shot device testing has been developed considerably recently, both in terms of estimation and optimal design under different lifetime distributions. However, one‐shot device testing analysis under lognormal lifetime distribution has not been studied yet. While the hazard function for exponential distribution is always a constant, and that of Weibull and gamma are either increasing or decreasing, the lognormal distribution has increasing ‐ decreasing behavior of hazard which is encountered often in practice as units usually experience early failure and then stabilize over time in terms of performance. In this paper, we develop the EM algorithm for the likelihood estimation based on one‐shot device test data under lognormal distribution and also the design of optimal CSALTs (constant stress accelerated life tests) under this set up with budget constraints. A simulation study is carried out to assess the performance of the methods of inference developed here and some real‐life data are analyzed for illustrative purpose.
A new multivariate CUSUM chart for monitoring of covariance matrix with individual observations under estimated parameter
Authors: Ajadi Jimoh Olawale , Wong Angus , Mahmood Tahir , Hung Kevin 
Published: November 2021

AbstractMultivariate charts for process dispersion detect changes in the variance‐covariance matrix of a process. Most of the existing multivariate charts for monitoring the dispersion of individual observations were designed based on exponentially weighted moving average (EWMA) charting schemes. However, an alternative to the EWMA scheme is the cumulative sum (CUSUM) control chart, which has proven to be better in some cases. In the last decades, few studies have been conducted on methods based on multivariate CUSUM (MCUSUM) schemes to monitor the covariance matrix of individual observations. Consequently, we propose a new MCUSUM dispersion chart. Besides, most of the existing methods have been developed by assuming that the process parameters are known and that the process distribution is normal; these assumptions are not always true in practice. Hence, we compare the performance of the proposed chart and its counterparts based on the estimation effects under normal and non‐normal distributions. The results show that the proposed chart outperforms the other charts in terms of minor shifts in the process. Similarly, the proposed chart is the most robust to the normality assumption among the compared charts. The average value of the conditional average run length was used as the performance measure. Finally, the proposed method was also implemented with a simulated dataset to support the stated proposal findings.
Chemoenzymatic Synthesis of D‐Glucaro‐δ‐lactam Containing Oligosaccharides as Putative Heparanase Inhibitors
Authors: Ni Minghong , Stancanelli Eduardo , Kayal Yasmin , Candido Marialuisa , Guerrini Marco , Vlodavsky Israel , Naggi Annamaria , Liu Jian , Petitou Maurice 
Published: November 2021

AbstractHeparanase is an endo‐β‐glycosidase that cleaves heparan sulfate chains at the level of the glycosidic bond of selected glucuronic acid residues. Heparin fragments, that can compete with heparan sulfate for binding to heparanase, have been reported as weak heparanase inhibitors. To reinforce their inhibitory activity, a known β‐glucuronidase inhibitor has been introduced at their reducing end to directly interfere with the active site of the enzyme. We report here the synthesis of such oligosaccharides, displaying D‐glucaro‐δ‐lactam at their reducing end. Thanks to the trichloroacetimidate glycosylation method, we could devise experimental conditions allowing O‐glycosylation of the lactam ring, and we thus chemically prepared trisaccharides that were further elongated and sulfated using enzymatic methods. Heparanase inhibitory activity was not significantly improved by the presence of the D‐glucaro‐δ‐lactam ring.
Kamishoyosan is effective for female patients with oral and nasal cavity problems
Authors: Tanaka Hidenori , Irie Yasuhito , Nakae Hajime 
Published: November 2021

ABSTRACTCaseThere were eight female patients who kamishoyosan (KSS) should be prescribed based on Kampo medical findings. The severity of the various symptoms was evaluated based on the numerical rating scale (NRS) score using KSS medication before and after 4 weeks. Effectiveness of KSS for each chief complaint such as glossalgia, dysgerusia, disorder of saliva, dysosmia, and stomatitis was evaluated on NRS decrease over 5.OutcomeKSS was effective in five (62.5%) of the eight patients after medication. The NRS score before medication was 8.3 (7–10), and the NRS score after the medication was 3.6 (1–8).ConclusionKSS is effective for female patients with oral and nasal cavity problems.
High prevalence of ulcerative appendicitis in patients with ulcerative colitis
Authors: Heuthorst Lianne , Mookhoek Aart , Wildenberg Manon E. , D'Haens Geert R. , Bemelman Willem A. , Buskens Christianne J. 
Published: November 2021

AbstractBackgroundPrevious studies have indicated that the appendix may be a priming site of ulcerative colitis (UC). Appendectomy is inversely associated with the development of UC, and is suggested to have a beneficial effect on the disease course in patients with refractory disease.ObjectiveThe aim of the current study was to assess histological features of appendices from patients with UC and their clinical relevance.MethodsPatients with UC in remission and active UC (therapy refractory) that underwent appendectomy between 2012 and 2019 were included. Histological features of UC appendices were compared to those of patients with acute appendicitis and colon carcinoma. The Robarts Histopathology Index (RHI) was used to assess appendiceal inflammation. In patients with active UC, histological and clinical characteristics were compared between patients with and without endoscopic response following appendectomy.ResultsIn total, 140 appendix specimens were assessed (n = 35 UC remission, n = 35 active UC, n = 35 acute appendicitis, n = 35 colon carcinoma). Histological features of appendices from UC patients looked like UC rather than acute appendicitis. The presence of active appendiceal inflammation was comparable between patients in remission versus active disease (53.7% vs. 46.3%, p = 0.45) and limited versus extensive disease (58.5% vs. 41.5%, p = 0.50). Endoscopic response (Mayo 0–1) following appendectomy, assessed in 28 therapy refractory patients, was more frequently seen in patients with higher RHI scores (RHI > 6: 81.8% vs. RHI ≤ 6: 9.1%, p = 0.03) and limited disease (proctitis/left sided 63.6% vs. pancolitis 36.4%, p = 0.02).ConclusionThe presence of active appendiceal inflammation is common in UC and does not correlate with colonic disease activity. More than 50% of UC patients in remission showed active histological disease in the appendix. Favorable response to appendectomy for refractory UC was seen in cases with ulcerative appendicitis. These findings might support the role of the appendix as a pivotal organ in UC.
Could MT2 be a singularity variable?
Authors: Park Chan Beom 
Published: November 2021

Abstract
The algebraic singularity method is a framework for analyzing collider events with missing energy. It provides a way to draw out a set of singularity variables that can catch singular features originating from the projection of full phase space onto the observable phase space of measured particle momenta. It is a promising approach applicable to various physics processes with missing energy but still requires more studies for use in practice. Meanwhile, in the double-sided decay topology with an invisible particle on each side, the MT2 variable has been known to be a useful collider observable for measuring particle masses from missing energy events or setting signal regions of collider searches. We investigate the relation between the two different types of kinematic variables in double-sided decay topology. We find that the singularity variables contain the MT2 variable in many cases, although the former is not a strict superset of the latter.
Visuospatial working memory and the construction of a spatial situation model in listening comprehension: An examination using a spatial tapping task
Authors: Lin Yun , Matsumi Norio 
Published: November 2021

AbstractThe present study investigated how visuospatial working memory (VSWM) is involved in the construction of a spatial situation model for spatial passages presented auditorily. A simple spatial tapping condition, a complex tapping condition as a target-tracking task, and a control condition, were used to analyze the role of VSWM. To understand how individuals who differ in verbal working memory (VWM) capacity (determined with a listening span test) process spatial text during dual-task performance, individual differences in VWM capacity were analyzed. In two experiments, the participants listened to a spatial text at the same time as performing a spatial concurrent task or no concurrent task. The results of the free recall test in Experiment 1 showed that there were no differences between the tapping conditions in the high VWM capacity group; the low VWM capacity group had a lower performance in both spatial tapping tasks compared to the control condition. The results of the map drawing test in Experiment 2 showed that complex spatial tapping impaired performance in comparison to simple spatial tapping and the control condition in the high VWM capacity group; in the low VWM capacity group, both spatial tapping tasks impaired recall performance. In addition, the participants with high VWM capacity demonstrated better performance. Overall, the results suggest that individuals with high VWM capacity have more resources to process verbal and spatial information than those with low VWM capacity, indicating that VWM capacity is related to the degree of the involvement of VSWM.
Sexual Double Standards: Contributions of Sexual Socialization by Parents, Peers, and the Media
Authors: Endendijk Joyce J. , Deković Maja , Vossen Helen , van Baar Anneloes L. , Reitz Ellen 
Published: November 2021

Abstract(Hetero)sexual double standards (SDS) entail that different sexual behaviors are appropriate for men and women. There is large variation in whether people endorse SDS in their expectations about the sexual behavior of women and men (i.e., SDS-norms). To explain these individual differences, we examined associations between SDS-norms of Dutch adolescents (aged 16–20 years,N = 566) and what parents, peers, and the media teach adolescents about appropriate sexual behavior of boys and girls (i.e., SDS-socialization). Adolescents completed an online survey at school. Regarding SDS-socialization, more traditional SDS-norms conveyed by the media and peers, but not of parents, and less perceived sexual activity of female peers, were associated with more traditional SDS-norms. Only for boys, exposure to sexy girls/women on social media and sexual music videos of female artists were associated with more traditional SDS-norms. Thus, SDS-socialization by peers and the media and opposite gender models (for boys) are important in light of adolescents’ SDS-norms.
Associations Between Psychosocial Well-Being, Stressful Life Events and Emotion-Driven Impulsiveness in European Adolescents
Authors: Do Stefanie , Coumans Juul M. J. , Börnhorst Claudia , Pohlabeln Hermann , Reisch Lucia A. , Danner Unna N. , Russo Paola , Veidebaum Toomas , Tornaritis Michael , Molnár Dénes , Hunsberger Monica , De Henauw Stefaan , Moreno Luis A. , Ahrens Wolfgang , Hebestreit Antje 
Published: November 2021

AbstractKnowing the extent to which mental well-being and stressful life events during adolescence contribute to personality characteristics related to risk-taking behaviors, such as emotion-driven impulsiveness, is highly relevant for the development of health promotion measures. This study examined whether psychosocial well-being and different stressful life events are associated with emotion-driven impulsiveness. In total, 3,031 adolescents (52% girls; Mage = 13.6 years) were included from the I. Family Study, a cross-sectional examination on lifestyle-related behaviors conducted across eight European countries in 2013/14. Linear mixed-effects regression models showed that higher psychosocial well-being was associated with lower emotion-driven impulsiveness independent of socio-demographic, health-related, and parental variables. A higher number of stressful life events was associated with higher emotion-driven impulsiveness. Psychosocial well-being and stressful life events need to be further considered in the development and tailoring of health promotion strategies that aim to reduce emotion-driven impulsiveness.
Large scale tensor regression using kernels and variational inference
Authors: Hu Robert , Nicholls Geoff K. , Sejdinovic Dino 
Published: November 2021

AbstractWe outline an inherent flaw of tensor factorization models when latent factors are expressed as a function of side information and propose a novel method to mitigate this. We coin our methodology kernel fried tensor (KFT) and present it as a large-scale prediction and forecasting tool for high dimensional data. Our results show superior performance against LightGBM and Field aware factorization machines (FFM), two algorithms with proven track records, widely used in large-scale prediction. We also develop a variational inference framework for KFT which enables associating the predictions and forecasts with calibrated uncertainty estimates on several datasets.