bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrino oscillation constraints on U(1)′ models: from non-standard interactions to long-range forces
Authors: Coloma Pilar , Gonzalez-Garcia M. C. , Maltoni Michele 
Published: January 2021

Abstract
We quantify the effect of gauge bosons from a weakly coupled lepton flavor dependent U(1)′ interaction on the matter background in the evolution of solar, atmospheric, reactor and long-baseline accelerator neutrinos in the global analysis of oscillation data. The analysis is performed for interaction lengths ranging from the Sun-Earth distance to effective contact neutrino interactions. We survey ∼ 10000 set of models characterized by the six relevant fermion U(1)′ charges and find that in all cases, constraints on the coupling and mass of the Z′ can be derived. We also find that about 5% of the U(1)′ model charges lead to a viable LMA-D solution but this is only possible in the contact interaction limit. We explicitly quantify the constraints for a variety of models including $$ \mathrm{U}{(1)}_{B-3{L}_e} $$
U

1

B
−
3

L
e

, $$ \mathrm{U}{(1)}_{B-3{L}_{\mu }} $$
U

1

B
−
3

L
μ

, $$ \mathrm{U}{(1)}_{B-3{L}_{\tau }} $$
U

1

B
−
3

L
τ

, $$ \mathrm{U}{(1)}_{B-\frac{3}{2}\left({L}_{\mu }+{L}_{\tau}\right)} $$
U

1

B
−

3
2

L
μ

+

L
τ

, $$ \mathrm{U}{(1)}_{L_e-{L}_{\mu }} $$
U

1

L
e

−

L
μ

, $$ \mathrm{U}{(1)}_{L_e-{L}_{\tau }} $$
U

1

L
e

−

L
τ

, $$ \mathrm{U}{(1)}_{L_e-\frac{1}{2}\left({L}_{\mu }+{L}_{\tau}\right)} $$
U

1

L
e

−

1
2

L
μ

+

L
τ

. We compare the constraints imposed by our oscillation analysis with the strongest bounds from fifth force searches, violation of equivalence principle as well as bounds from scattering experiments and white dwarf cooling. Our results show that generically, the oscillation analysis improves over the existing bounds from gravity tests for Z′ lighter than ∼ 10−8→ 10−11 eV depending on the specific couplings. In the contact interaction limit, we find that for most models listed above there are values of g′ and MZ′ for which the oscillation analysis provides constraints beyond those imposed by laboratory experiments. Finally we illustrate the range of Z′ and couplings leading to a viable LMA-D solution for two sets of models.
On-chip mass spectrometric analysis in non-polar solvents by liquid beam infrared matrix-assisted laser dispersion/ionization
Authors: Urban Raphael D. , Fischer Tillmann G. , Charvat Ales , Wink Konstantin , Krafft Benjamin , Ohla Stefan , Zeitler Kirsten , Abel Bernd , Belder Detlev 
Published: January 2021

AbstractBy the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates this free liquid jet consisting of water as the continuous phase and the non-polar solvent as the dispersed droplet phase, the solutes in the droplets are ionized. This ionization at atmospheric pressure enables the mass spectrometric analysis of non-polar compounds with the aid of a surrounding aqueous matrix that absorbs IR light. This works both for non-polar solvents such as n-heptane and for water non-miscible solvents like chloroform. In a proof of concept study, this approach is applied to monitor a photooxidation of N-phenyl-1,2,3,4-tetrahydroisoquinoline.
Graphical abstract
Active Breaks Initiative During Hospital Rounds in the Surgical ICU to Improve Wellness of Healthcare Providers: An Observational Descriptive Study
Authors: Armas Maria , Aronowitz Danielle , Gaona Richard , Coppa Gene , Barrera Rafael 
Published: January 2021

AbstractBackgroundHealthcare professionals in the intensive care unit (ICU) confront stressful working conditions. Morning rounds involve several hours of prolonged standing and uninterrupted concentration each day and require both mental and physical endurance from the entire care team. There is concern that work‐related fatigue among ICU practitioners will compromise their ability to safely and effectively care for their patients. To address this concern, the surgical intensive care unit (SICU) at Long Island Jewish Medical Center implemented an initiative to promote provider wellness through “active breaks” during rounds.Materials and methodsBetween October and December 2019, 30 physicians, physician assistants, nurses, and students collectively engaged in active breaks during SICU rounds and then completed a 7‐question, post‐test survey to assess their experience. The survey consisted of both closed‐end and open‐ended questions. The data were then analyzed using simple statistics.ResultsIn response to closed‐ended questioning, the majority of participants agreed that active breaks relieved stress (27/30; 90%), promoted wellness (29/30; 96.7%), and improved team morale (29/30; 93.1%). When given the options of tricep dips, squats or push‐ups, squats were the favored activity during breaks (17/30; 56.7%). Most of the participants (27/30; 90%) considered the active breaks to be appropriate for the working environment; two participants had no opinion on this matter. Approximately 90% of the respondents were interested in maintaining active breaks as part of the routine of morning rounds.ConclusionsOur assessment suggests active breaks during rounds are a healthy outlet to address the inherent stress associated with critical care. This initiative also potentially protects healthcare providers from burnout and, consequentially, improves the quality of patient care.
Comparative Analysis of Three‐Versus Two‐dimensional Imaging in Laparoscopic Cholecystectomy
Authors: Tauriainen Asta , Biancari Fausto , Tauriainen Tuomas 
Published: January 2021

AbstractBackgroundThree‐dimensional (3D) imaging has been suggested to improve learning and performance of laparoscopy. We sought to investigate whether 3D imaging could improve the outcomes after laparoscopic cholecystectomy.Materials and methodsTwo‐hundred and forty‐one consecutive patients underwent elective or urgent laparoscopic cholecystectomy using 2D (n = 111) and 3D (n = 130) imaging equipments from March 2017 to March 2019 at the Kainuu Central Hospital, Finland. The main outcomes of this study were biliary tract injury, conversion to open procedure and procedure duration.ResultsIn the overall series, there were 5 cases of biliary tract injury (2.1%). When compared to 3D imaging, 2D was associated with increased risk of biliary tract injury in the overall series (0% in 3D vs. 4.7% in 2D, p = 0.026) in addition to a subgroup of acute cholecystitis patients operated by senior surgeons (n = 92), 0% in 3D group (n = 60) vs. 10.0% in 2D group (n = 32), p = 0.037 in univariate analysis. The rates of conversion to open surgery did not differ between the groups in the overall series (5.3 vs 5.7%, p = 0.909) or any of the subgroups. Duration of surgery with 3D vs. 2D imaging were comparable in the elective (57.0 ± 16.3 vs. 54.1 ± 18.9 min, p = 0.228) and urgent setting (66.9 ± 15.1 vs. 67.4 ± 16.6 min, p = 0.805). Such differences were not significant in multivariate analysis.ConclusionsThe present study suggests that the use of 3D imaging is significantly associated with a reduced risk of intraoperative biliary tract injury during laparoscopic cholecystectomy especially in acute cholecystitis.
TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes
Authors: Zhou Xinyu , Li Ang , Lin Pei-hui , Zhou Jingsong , Ma Jianjie 
Published: January 2021

AbstractTrimeric intracellular cation (TRIC) channels have been identified as monovalent cation channels that are located in the ER/SR membrane. Two isoforms discovered in mammals are TRIC-A (TMEM38a) and TRIC-B (TMEM38b). TRIC-B ubiquitously expresses in all tissues, and TRIC-B−/− mice is lethal at the neonatal stage. TRIC-A mainly expresses in excitable cells. TRIC-A−/− mice survive normally but show abnormal SR Ca2+ handling in both skeletal and cardiac muscle cells. Importantly, TRIC-A mutations have been identified in human patients with stress-induced arrhythmia. In the past decade, important discoveries have been made to understand the structure and function of TRIC channels, especially its role in regulating intracellular Ca2+ homeostasis. In this review article, we focus on the potential roles of TRIC-A in regulating cardiac function, particularly its effects on intracellular Ca2+ signaling of cardiomyocytes and discuss the current knowledge gaps.
Rice protein-binding microarrays: a tool to detect cis-acting elements near promoter regions in rice
Authors: Kim Joung Sug , Chae SongHwa , Jun Kyong Mi , Lee Gang-Seob , Jeon Jong-Seong , Kim Kyung Do , Kim Yeon-Ki 
Published: January 2021

Abstract
Main conclusion
The present study showed that a rice (Oryza sativa)-specific protein-binding microarray (RPBM) can be applied to analyze DNA-binding motifs with a TF where binding is evaluated in extended natural promoter regions. The analysis may facilitate identifying TFs and their downstream genes and constructing gene networks through cis-elements.

Abstract
Transcription factors (TFs) regulate gene expression at the transcriptional level by binding a specific DNA sequence. Thus, predicting the DNA-binding motifs of TFs is one of the most important areas in the functional analysis of TFs in the postgenomic era. Although many methods have been developed to address this challenge, many TFs still have unknown DNA-binding motifs. In this study, we designed RPBM with 40-bp probes and 20-bp of overlap, yielding 49 probes spanning the 1-kb upstream region before the translation start site of each gene in the entire genome. To confirm the efficiency of RPBM technology, we selected two previously studied TFs, OsWOX13 and OsSMF1, and an uncharacterized TF, OsWRKY34. We identified the ATTGATTG and CCACGTCA DNA-binding sequences of OsWOX13 and OsSMF1, respectively. In total, 635 and 932 putative feature genes were identified for OsWOX13 and OsSMF1, respectively. We discovered the CGTTGACTTT DNA-binding sequence and 195 putative feature genes of OsWRKY34. RPBM could be applicable in the analysis of DNA-binding motifs for TFs where binding is evaluated in the promoter and 5′ upstream CDS regions. The analysis may facilitate identifying TFs and their downstream genes and constructing gene networks through cis-elements.
Olfactory processing in the lateral horn of Drosophila
Authors: Das Chakraborty Sudeshna , Sachse Silke 
Published: January 2021

AbstractSensing olfactory signals in the environment represents a crucial and significant task of sensory systems in almost all organisms to facilitate survival and reproduction. Notably, the olfactory system of diverse animal phyla shares astonishingly many fundamental principles with regard to anatomical and functional properties. Binding of odor ligands by chemosensory receptors present in the olfactory peripheral organs leads to a neuronal activity that is conveyed to first and higher-order brain centers leading to a subsequent odor-guided behavioral decision. One of the key centers for integrating and processing innate olfactory behavior is the lateral horn (LH) of the protocerebrum in insects. In recent years the LH of Drosophila has garnered increasing attention and many studies have been dedicated to elucidate its circuitry. In this review we will summarize the recent advances in mapping and characterizing LH-specific cell types, their functional properties with respect to odor tuning, their neurotransmitter profiles, their connectivity to pre-synaptic and post-synaptic partner neurons as well as their impact for olfactory behavior as known so far.
Near-real-time volcanic cloud monitoring: insights into global explosive volcanic eruptive activity through analysis of Volcanic Ash Advisories
Authors: Engwell S. , Mastin L. , Tupper A. , Kibler J. , Acethorp P. , Lord G. , Filgueira R. 
Published: January 2021

AbstractUnderstanding the location, intensity, and likely duration of volcanic hazards is key to reducing risk from volcanic eruptions. Here, we use a novel near-real-time dataset comprising Volcanic Ash Advisories (VAAs) issued over 10 years to investigate global rates and durations of explosive volcanic activity. The VAAs were collected from the nine Volcanic Ash Advisory Centres (VAACs) worldwide. Information extracted allowed analysis of the frequency and type of explosive behaviour, including analysis of key eruption source parameters (ESPs) such as volcanic cloud height and duration. The results reflect changes in the VAA reporting process, data sources, and volcanic activity through time. The data show an increase in the number of VAAs issued since 2015 that cannot be directly correlated to an increase in volcanic activity. Instead, many represent increased observations, including improved capability to detect low- to mid-level volcanic clouds (FL101–FL200, 3–6 km asl), by higher temporal, spatial, and spectral resolution satellite sensors. Comparison of ESP data extracted from the VAAs with the Mastin et al. (J Volcanol Geotherm Res 186:10–21, 2009a) database shows that traditional assumptions used in the classification of volcanoes could be much simplified for operational use. The analysis highlights the VAA data as an exceptional resource documenting global volcanic activity on timescales that complement more widely used eruption datasets.
The prevalence of intestinal dysbiosis in patients referred for antireflux surgery
Authors: Haworth Jordan J. , Boyle Nicholas , Vales Andres , Hobson Anthony R. 
Published: January 2021

Abstract
Background
Prior to antireflux surgery, most patients with symptoms of gastroesophageal reflux disease (GERD) have been taking long-term proton pump inhibitors (PPIs). PPIs have been shown to cause changes to the intestinal microbiota, such as small intestinal bacterial overgrowth (SIBO), which is characterised by symptoms of gas bloating. Patients undergoing antireflux surgery are not routinely screened for SIBO, yet many patients experience gas-related symptoms postoperatively.

Methods
Data from consecutive patients (n = 104) referred to a speciality reflux centre were retrospectively assessed. Patients underwent a routine diagnostic workup for GERD including history, endoscopy, oesophageal manometry and 24-h pH-impedance monitoring off PPIs. Intestinal dysbiosis was determined by hydrogen and methane breath testing with a hydrogen-positive result indicative of SIBO and a methane-positive result indicative of intestinal methanogen overgrowth (IMO).

Results
60.6% of patients had intestinal dysbiosis (39.4% had SIBO and 35.6% had IMO). Patients with dysbiosis were more likely to report bloating (74.6% vs 48.8%; P = 0.01) and belching (60.3% vs 34.1%; P = 0.01). The oesophageal acid exposure time and number of reflux episodes were similar between dysbiosis and non-dysbiosis groups, but patients with dysbiosis were more likely to have a positive reflux-symptom association (76.2% vs 31.7%; P < 0.001), especially for regurgitation in those with SIBO (P = 0.01). Hydrogen gas production was significantly greater in patients with a positive reflux-symptom association for regurgitation (228.8 ppm vs 129.1 ppm, P = 0.004) and belching (mean AUC 214.8 ppm vs 135.9 ppm, P = 0.02).

Conclusions
The prevalence of intestinal dysbiosis is high in patients with GERD, and these patients are more likely to report gas-related symptoms prior to antireflux surgery. Independently, SIBO may be a contributory factor to refractory reflux symptoms and gas bloating in antireflux surgery candidates.
Relative qPCR to quantify colonization of plant roots by arbuscular mycorrhizal fungi
Authors: Bodenhausen Natacha , Deslandes-Hérold Gabriel , Waelchli Jan , Held Alain , van der Heijden Marcel G. A. , Schlaeppi Klaus 
Published: January 2021

AbstractArbuscular mycorrhiza fungi (AMF) are beneficial soil fungi that can promote the growth of their host plants. Accurate quantification of AMF in plant roots is important because the level of colonization is often indicative of the activity of these fungi. Root colonization is traditionally measured with microscopy methods which visualize fungal structures inside roots. Microscopy methods are labor-intensive, and results depend on the observer. In this study, we present a relative qPCR method to quantify AMF in which we normalized the AMF qPCR signal relative to a plant gene. First, we validated the primer pair AMG1F and AM1 in silico, and we show that these primers cover most AMF species present in plant roots without amplifying host DNA. Next, we compared the relative qPCR method with traditional microscopy based on a greenhouse experiment with Petunia plants that ranged from very high to very low levels of AMF root colonization. Finally, by sequencing the qPCR amplicons with MiSeq, we experimentally confirmed that the primer pair excludes plant DNA while amplifying mostly AMF. Most importantly, our relative qPCR approach was capable of discriminating quantitative differences in AMF root colonization and it strongly correlated (Spearman Rho = 0.875) with quantifications by traditional microscopy. Finally, we provide a balanced discussion about the strengths and weaknesses of microscopy and qPCR methods. In conclusion, the tested approach of relative qPCR presents a reliable alternative method to quantify AMF root colonization that is less operator-dependent than traditional microscopy and offers scalability to high-throughput analyses.
Accuracy of intraoral scan images in full arch with orthodontic brackets: a retrospective in vivo study
Authors: Kim Young-Kyun , Kim So-Hyun , Choi Tae-Hyun , Yen Edwin H. , Zou Bingshuang , Shin Yonsoo , Lee Nam-Ki 
Published: January 2021

Abstract
Objectives
The purpose of this retrospective study was to evaluate the accuracy of intraoral scan (IOS) images in the maxillary and mandibular arches with orthodontic brackets.

Material and methods
From digital impressions of 140 patients who underwent orthodontic treatment, consecutive IOS images were selected based on standardized inclusion criteria: Two pre-orthodontic IOS images (IOS1 and IOS2) of permanent dentition with fully erupted second molars and IOS images obtained immediately after orthodontic bracket bonding (IOSb). Superimpositions were performed to evaluate the reproducibility of repeated IOS images. Accuracy of IOSb images was analyzed by comparing the average surface errors between IOS1c and IOS2c images, which were IOS images cut based on the same region of the interest as between IOS1 and IOSb images.

Results
A total of 84 IOS images was analyzed. The average surface errors between IOS1 and IOS2 images were 57 ± 8 μm and 59 ± 14 μm in the maxillary and mandibular arch, respectively, and their reliability was almost perfect. The average errors between IOSb and IOS1c images exhibited an increase, which measured 97 ± 28 μm in the maxillary arch and 95 ± 29 μm in the mandibular arch. These surface deviations between IOSb and IOS1c images were significantly larger in each region as well as entire dentition (P < 0.001) compared to those between IOS1c and IOS2c images.

Conclusions
The average surface errors of the scans with brackets showed increased values compared with those without brackets. This suggests that orthodontic brackets could affect the trueness of intraoral scan images.

Clinical relevance
It is necessary for clinicians to consider the effect of brackets on digital impression when using IOS images in orthodontic patients.
Incidence and risk factors for respiratory tract bacterial colonization and infection in lung transplant recipients
Authors: Paglicci L. , Borgo V. , Lanzarone N. , Fabbiani M. , Cassol C. , Cusi MG. , Valassina M. , Scolletta S. , Bargagli E. , Marchetti L. , Paladini P. , Luzzi L. , Fossi A. , Bennett D. , Montagnani F. 
Published: January 2021

AbstractTo evaluate incidence of and risk factors for respiratory bacterial colonization and infections within 30 days from lung transplantation (LT). We retrospectively analyzed microbiological and clinical data from 94 patients transplanted for indications other than cystic fibrosis, focusing on the occurrence of bacterial respiratory colonization or infection during 1 month of follow-up after LT. Thirty-three percent of patients developed lower respiratory bacterial colonization. Bilateral LT and chronic heart diseases were independently associated to a higher risk of overall bacterial colonization. Peptic diseases conferred a higher risk of multi-drug resistant (MDR) colonization, while longer duration of aerosol prophylaxis was associated with a lower risk. Overall, 35% of lung recipients developed bacterial pneumonia. COPD (when compared to idiopathic pulmonary fibrosis, IPF) and higher BMI were associated to a lower risk of bacterial infection. A higher risk of MDR infection was observed in IPF and in patients with pre-transplant colonization and infections. The risk of post-LT respiratory infections could be stratified by considering several factors (indication for LT, type of LT, presence of certain comorbidities, and microbiologic assessment before LT). A wider use of early nebulized therapies could be useful to prevent MDR colonization, thus potentially lowering infectious risk.
Large deformation dynamic analysis of progressive failure in layered clayey slopes under seismic loading using the particle finite element method
Authors: Wang Liang , Zhang Xue , Tinti Stefano 
Published: January 2021

AbstractThis paper presents the failure analysis of layered clayey slopes with emphasis on the combined effect of the clay’s weakening behavior and the seismic loading using the particle finite element method (PFEM). Diverse failure mechanisms have been disclosed via the PFEM modelling when the strain-weakening behavior of clay is concerned. In contrast to a single layered slope exhibiting either a shallow or a deep failure mode, a layered slope may undergo both failure modes with a time interval in between. Seismic loadings also enlarge the scale of slope failure in clays with weakening behavior. The failure of a real layered slope (i.e. the 1988 Saint-Adelphe landslide, Canada) triggered by the Saguenay earthquake is also studied in this paper. The simulation results reveal that the choice of the strain-softening value controls the slip surface of the landslide and the amplification effect is important in the triggering of the landslide.
Interaktive Vorlesungsfolien mit SQL-Unterstützung
Authors: Schildgen Johannes 
Published: January 2021

ZusammenfassungMit PowerPoint oder LaTeX Beamer erstellte Vorlesungsfolien sind meist statisch und dienen hauptsächlich der Präsentation von Lehrinhalten. Als Alternative dazu werden drei Erweiterungen für das HTML- und JavaScript-basierte Präsentationsframework reveal.js vorgestellt, die für mehr Interaktion in der Datenbankenlehre sorgen sollen: (1) Eine Live-Ausführung von SQL-Anfragen und eine Darstellung des Anfrageergebnisses direkt auf der Folie; mit Möglichkeit zur Anpassung der Anfrage im Präsentationsbetrieb, (2) eine JSON-basierte Beschreibung von ER-Diagrammen, welche graphisch auf den Folien dargestellt werden sollen und (3) eingebettete Smartphone-Umfragen, um zwischendurch – ohne einen Kontextwechsel – Quiz-Fragen zu stellen.