bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pertimbangan Kekuatan, Kelemahan, Peluang, Ancaman dalam Keputusan Penerbitan Saham Bank Umum Syariah
Authors: Ida Syafrida  , Taufik Awaludin  , Herbirowo Nugroho  
Published: September 2021

This research’s goal is to compose the dominant element and sub elements from the strenghts, weaknesses, opportunities, threats (SWOT) in Islamic Commercial Banks in increasing funding sources through the issuance of public shares. In Indonesia, until the end of 2020, there are only 3 Islamic Banks that have issued shares. The Analytical Network Process, from indepth interviews, is used in this research to reveal the knowledge and experience of experts. Strengths and opportunities are the dominant element of SWOT. Owner promotion (strength), financial performance’s reduction (weakness), broad investor base (opportunity), and complex emission formality (threat) are the dominant sub-elements of SWOT.

Abstrak
Penelitian ini bertujuan untuk merumuskan elemen dan sub-elemen dominan dari SWOT pada Bank Umum Syariah dalam meningkatkan sumber pendanaan melalui penerbitan saham publik. Di Indonesia hingga akhir tahun 2020 baru 3 bank syariah yang telah menerbitkan saham. Penelitian ini menggunakan Analytical Network Process berdasarkan data primer dari wawancara mendalam untuk menggali pengetahuan dan pengalaman para praktisi ahli. Unsur dominan dari SWOT adalah kekuatan dan diikuti dengan peluang. Sub elemen yang dominan yaitu: dukungan pemilik (kekuatan), kinerja keuangan yang menurun (kelemahan), basis investor yang luas (peluang), dan formalitas emisi yang kompleks (ancaman).
Aplikasi Pengukuran Kinerja dengan Balanced Scorecard pada Rumah Sakit
Authors: Mesra Berlyn Hakim  , Ali Djamhuri  , Bambang Hariadi  
Published: September 2021

This study analyze the Muhammadiyah Lamongan Hospital performance based on four perspectives: a financial, costumer, internal business, learning and growth. The research method used a case study. Research Results Measurement of the financial perspective shows that from the results of liquidity, profitability, and solvency, Muhammadiyah Hospital Lamongan gets good results. This study results from the perspective of customers that are generally also good, which is represented by the views of most customers who value hospital services as quite good.

AbstrakTujuan dari penelitian ini adalah menganalisis kinerja Rumah Sakit Muhammadiyah Lamongan berdasarkan empat persepektif yang meliputi keuangan, pelanggan, bisnis internal dan pembelajaran dan pertumbuhan. Metode penelitian adalah studi kasus. Hasil Penelitian pengukuran perspektif keuangan menunjukkan bahwa Rumah Sakit Muhammadiyah Lamongan memiliki kondisi keuangan yang cukup baik, sejalan dengan hasil dari perspektif pelanggan yang secara umum juga baik yang direpresentasikan oleh pandangan sebagian besar pelanggan yang menilai pelayanan rumah sakit yang cukup baik.
Efektivitas Komite Audit dan Manajemen Laba
Authors: Mei Rinta  
Published: September 2021

This study investigates the effectiveness of corporate governance and earnings’ management. During 2016-2018, 333 samples of manufacturing companies were obtained. Multiple linear regression method was used to analyze data. The test results show that the number of board of directors’ members and earnings’ management have a negative insignificant, the audit committee meetings have a negative significant, and the number of audit committee’s members have a positive insignificant. This study contributes to enrich the earnings’ management literature and adds novelty in how corporate governance structures interact to influence earnings’ management.

Abstrak
Kajian ini menyelidiki efektivitas tata kelola perusahaan dan manajemen laba. Selama tahun 2016-2018, diperoleh 333 sampel perusahaan manufaktur. Metode regresi linier berganda digunakan untuk menganalisis data. Hasil pengujian memperlihatkan jumlah anggota dewan direksi dan manajemen laba mempunyai hasil tidak signifikan negatif, pertemuan komite audit mempunyai hasil signifikan negatif, dan jumlah anggota komite audit mempunyai hasil tidak signifikan positif. Penelitian ini berkontribusi dalam memperkaya literatur manajemen laba dan menambah kebaruan pada bagaimana struktur tata kelola perusahaan berinteraksi untuk memengaruhi manajemen laba.
Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis
Authors: Bianco Bianca , Loureiro Flavia Altheman , Trevisan Camila Martins , Peluso Carla , Christofolini Denise Maria , Montagna Erik , Laganà Antonio Simone , Barbosa Caio Parente 
Published: September 2021

BackgroundSingle nucleotide variants (SNVs) FSHB:c.-211G&gt;T, FSHR:c.919G&gt;A, and FSHR:c.2039G&gt;A were reported to be associated with the variability in FSH and LH levels, and in vitro fertilization (IVF) outcomes. In this study, we aimed to evaluate the effects of FSHB:c.-211G&gt;T, FSHR:c.919G&gt;A, and FSHR:c.2039G&gt;A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis.MethodsA cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models, and the combined effects of the SNVs were evaluated using the multifactorial dimensionality reduction method.ResultsFSHB:c.-211G&gt;T affected LH levels in women with overall endometriosis and minimal/mild disease. FSHR:c.919G&gt;A affected FSH levels in women with overall endometriosis and the number of oocytes retrieved in those with moderate/severe endometriosis. Moreover, the FSHR:c.2039G&gt;A affected FSH levels in women with overall endometriosis, LH levels and total amount of rFSH in those with minimal/mild disease, and number of follicles and number of oocytes retrieved in those with moderate/severe endometriosis. No effect on hormone profile or reproductive outcomes was observed when the genotypes were combined.ConclusionsVariants of the FSHB and FSHR genes separately interfered with the hormonal profiles and IVF outcomes of women with endometriosis.
Clinicopathological and Prognostic Significance of Long Non-coding RNA MIAT in Human Cancers: A Review and Meta-Analysis
Authors: Wang Yongfeng , Fu Liangyin , Lu Tingting , Zhang Guangming , Zhang Jiawei , Zhao Yuanbin , Jin Haojie , Yang Kehu , Cai Hui 
Published: September 2021

Background: Although the treatment of cancer has made evident progress, its morbidity and mortality are still high. A tumor marker is a critical indicator for early cancer diagnosis, and timely cancer detection can efficiently help improve the prognosis of patients. Therefore, it is necessary to identify novel markers associated with cancer. LncRNA myocardial infarction associated transcript (MIAT) is a newly identified tumor marker, and in this study, we aimed to explore the relationship between MIAT and clinicopathological features and patient prognosis.Methods: We searched PubMed, Embase, Web of Science, and The Cochrane Library from inception to September 2020 to identify correlational studies. Then, we extracted valid data and used Stata software to make forest plots. We used the hazard ratio (HR) or odds ratio (OR) with 95% CI to evaluate the relationship between aberrant expression of MIAT and patients' prognosis and clinicopathological features.Results: The study included 21 studies, containing 2,048 patients. Meta-analysis showed that overexpression of lncRNA MIAT was associated with poor overall survival (OS) (HR = 1.60, 95% CI, 1.31–1.96, p &lt; 0.001). In addition, high expression of MIAT could forecast tumor size (OR = 2.26, 95% CI 1.34–3.81, p = 0.002), distant metastasis (OR = 2.54, 95% CI 1.84–3.50, p &lt; 0.001), TNM stage (OR = 2.38, 95% CI 1.36–4.18, p = 0.002), lymph node metastasis (OR = 2.59, 95% CI 1.25–5.36, p = 0.011), and the degree of differentiation (OR = 2.65, 95% CI 1.54–4.58, p &lt; 0.001). However, other clinicopathological features, including age (OR = 1.07, 95% CI 0.87–1.32, p = 0.516), gender (OR = 0.95, 95% CI 0.77–1.19, p = 0.668), and histology (OR = 0.72, 95% CI 0.48–1.10, p = 0.128) were not significantly different from high expression of MIAT.Conclusions: Our study showed that overexpression of MIAT is related to poor overall survival and clinicopathological features. MIAT can be considered a novel tumor marker to help diagnose tumors earlier and improve patient prognosis.
Enhanced Spin Accumulation in Semiconductor at Room Temperature Using Ni0.65Zn0.35Fe2O4(NZFO) as Spin Injector in NZFO/MgO/p-Si Device
Authors: Maji Nilay , Shit Subhasis , Nath T. K. 
Published: September 2021

In this article, the fabrication of a Ni0.65Zn0.35Fe2O4/MgO/p-Si heterostructure device has been optimized using the pulsed laser deposition (PLD) technique, and a detailed investigation of its structural, electrical, and magnetic features has been performed experimentally. The electronic and magneto-transport characteristics have been explored in the temperature range of 100–300 K. The current-voltage (I-V) characteristics of the heterojunction have been recorded, which displayed an excellent rectifying magnetic tunnel diode-like behavior throughout that temperature regime. The application of an external magnetic field parallel to the plane of the NZFO film causes the current (I) across the junction to decrease, clearly indicating positive junction magnetoresistance (JMR) of the heterostructure. The root of displaying positive magnetoresistance in our heterojunction has been well justified using the standard spin injection model. The electrical injection of spin-polarized carriers and its accumulation and detection in a p-Si channel have been demonstrated using the NZFO/MgO tunnel contact using a three-terminal (3-T) Hanle device. The parameters such as spin lifetime (99 ps), spin diffusion length (276 nm), and spin polarization (0.44) have been estimated from the Hanle curve detected in our heterostructure at room temperature, making the Ni0.65Zn0.35Fe2O4/MgO/p-Si device a very favorable promising junction structure in the field of spintronics for several device appliances in the future.
Artificial Intelligence for COVID-19: A Systematic Review
Authors: Wang Lian , Zhang Yonggang , Wang Dongguang , Tong Xiang , Liu Tao , Zhang Shijie , Huang Jizhen , Zhang Li , Chen Lingmin , Fan Hong , Clarke Mike 
Published: September 2021

Background: Recently, Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), has affected more than 200 countries and lead to enormous losses. This study systematically reviews the application of Artificial Intelligence (AI) techniques in COVID-19, especially for diagnosis, estimation of epidemic trends, prognosis, and exploration of effective and safe drugs and vaccines; and discusses the potential limitations.Methods: We report this systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched PubMed, Embase and the Cochrane Library from inception to 19 September 2020 for published studies of AI applications in COVID-19. We used PROBAST (prediction model risk of bias assessment tool) to assess the quality of literature related to the diagnosis and prognosis of COVID-19. We registered the protocol (PROSPERO CRD42020211555).Results: We included 78 studies: 46 articles discussed AI-assisted diagnosis for COVID-19 with total accuracy of 70.00 to 99.92%, sensitivity of 73.00 to 100.00%, specificity of 25 to 100.00%, and area under the curve of 0.732 to 1.000. Fourteen articles evaluated prognosis based on clinical characteristics at hospital admission, such as clinical, laboratory and radiological characteristics, reaching accuracy of 74.4 to 95.20%, sensitivity of 72.8 to 98.00%, specificity of 55 to 96.87% and AUC of 0.66 to 0.997 in predicting critical COVID-19. Nine articles used AI models to predict the epidemic of the COVID-19, such as epidemic peak, infection rate, number of infected cases, transmission laws, and development trend. Eight articles used AI to explore potential effective drugs, primarily through drug repurposing and drug development. Finally, 1 article predicted vaccine targets that have the potential to develop COVID-19 vaccines.Conclusions: In this review, we have shown that AI achieved high performance in diagnosis, prognosis evaluation, epidemic prediction and drug discovery for COVID-19. AI has the potential to enhance significantly existing medical and healthcare system efficiency during the COVID-19 pandemic.
Fibroglandular Tissue and Background Parenchymal Enhancement on Breast MR Imaging Correlates With Breast Cancer
Authors: Hu Xiaoxin , Jiang Luan , You Chao , Gu Yajia 
Published: September 2021

ObjectivesTo evaluate the association of breast cancer with both the background parenchymal enhancement intensity and volume (BPEI and BPEV, respectively) and the amount of fibroglandular tissue (FGT) using an automatic quantitative assessment method in breast magnetic resonance imaging (MRI).Materials and MethodsAmong 17,274 women who underwent breast MRI, 132 normal women (control group), 132 women with benign breast lesions (benign group), and 132 women with breast cancer (cancer group) were randomly selected and matched by age and menopausal status. The area under the receiver operating characteristic curve (AUC) was compared in Cancer vs Control and Cancer vs Benign groups to assess the discriminative ability of BPEI, BPEV and FGT.ResultsCompared with the control groups, the cancer group showed a significant difference in BPEV with a maximum AUC of 0.715 and 0.684 for patients in premenopausal and postmenopausal subgroup, respectively. And the cancer group showed a significant difference in BPEV with a maximum AUC of 0.622 and 0.633 for patients in premenopausal and postmenopausal subgroup, respectively, when compared with the benign group. FGT showed no significant difference when breast cancer group was compared with normal control and benign lesion group, respectively. Compared with the control groups, BPEI showed a slight difference in the cancer group. Compared with the benign group, no significant difference was seen in cancer group.ConclusionIncreased BPEV is correlated with a high risk of breast cancer While FGT is not.
Influencing Factors and Cumulative Risk Analysis of Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma
Authors: Yin Yirong , Xu Xiang , Shen Liyan , Zhao Wenjuan , Diao Hongcui , Li Chengqian 
Published: September 2021

ObjectiveTo explore the influencing factors and cumulative risk of lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC) patients.Methods607 patients confirmed PTMC pathologically after thyroidectomy were enrolled in this retrospective study. The rate of LNM was calculated. Different clinicopathological characteristics were compared in PTMC patients with and without LNM and in different subgroups of LNM, respectively. Correlation between clinicopathological characteristics and LNM was analyzed and the cumulative risk of LNM according to different clinicopathological characteristics was calculated.Results(1) There were 228 cases (37.56%) of PTMC combined with LNM. Compared with the non-lymph node metastasis group, the proportion of age &lt;55 years, male, multiple foci, bilateral foci, diameter&gt;0.5cm, extracapsular invasion, HT and intermediate-to-high risk stratification for recurrence of the LNM group was significantly increased (all p&lt;0.05);(2) Multivariate logistic regression analysis showed that age &lt;55years, male, multiple foci, diameter&gt;0.5cm,HT were independently positively correlated with LNM (all p &lt;0.05); (3) Subgroup analysis showed that women aged &lt;55 years combined with HT and aged≥55 years combined with BMI≥25 kg/m2 were independently positively associated with LNM; (4) With the increase of the tumor diameter, the cumulative risk of LNM in group of age &lt;55 years, males, and multiple foci increased gradually, and was higher than those of age≥55 years, females and single foci, respectively. (5) Among the 228 cases of LNM, the proportion of lymph nodes (LN) &gt;5 and the positive rate of LN were both higher in male group than that in the female group. The proportion of multiple foci and HT in LLNM group was higher than that in CLNM group (all P&lt;0.05).ConclusionAge &lt;55 years, males, multiple foci, diameter &gt;0.5cm and HT were independent risk factors of LNM; HT was an independent risk factor for LNM in female &lt;55 years old, and BMI≥25 kg/m2 was an independent risk factor for LNM in female ≥55 years old; The increase of tumor diameter in age &lt;55 years, males, multiple foci, and bilateral foci increased the cumulative risk of LNM, respectively; The number of LNM and the positive rate of LNM were both higher in male, and patients with multiple foci or HT were more likely to develop into LLNM.
Identification of Hub Genes Associated With Clear Cell Renal Cell Carcinoma by Integrated Bioinformatics Analysis
Authors: Huang Hao , Zhu Ling , Huang Chao , Dong Yi , Fan Liangliang , Tao Lijian , Peng Zhangzhe , Xiang Rong 
Published: September 2021

BackgroundClear cell renal cell carcinoma (ccRCC) is a common genitourinary cancer type with a high mortality rate. Due to a diverse range of biochemical alterations and a high level of tumor heterogeneity, it is crucial to select highly validated prognostic biomarkers to be able to identify subtypes of ccRCC early and apply precision medicine approaches.MethodsTranscriptome data of ccRCC and clinical traits of patients were obtained from the GSE126964 dataset of Gene Expression Omnibus and The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) database. Weighted gene co-expression network analysis (WGCNA) and differentially expressed gene (DEG) screening were applied to detect common differentially co-expressed genes. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes analysis, survival analysis, prognostic model establishment, and gene set enrichment analysis were also performed. Immunohistochemical analysis results of the expression levels of prognostic genes were obtained from The Human Protein Atlas. Single-gene RNA sequencing data were obtained from the GSE131685 and GSE171306 datasets.ResultsIn the present study, a total of 2,492 DEGs identified between ccRCC and healthy controls were filtered, revealing 1,300 upregulated genes and 1,192 downregulated genes. Using WGCNA, the turquoise module was identified to be closely associated with ccRCC. Hub genes were identified using the maximal clique centrality algorithm. After having intersected the hub genes and the DEGs in GSE126964 and TCGA-KIRC dataset, and after performing univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses, ALDOB, EFHD1, and ESRRG were identified as significant prognostic factors in patients diagnosed with ccRCC. Single-gene RNA sequencing analysis revealed the expression profile of ALDOB, EFHD1, and ESRRG in different cell types of ccRCC.ConclusionsThe present results demonstrated that ALDOB, EFHD1, and ESRRG may act as potential targets for medical therapy and could serve as diagnostic biomarkers for ccRCC.
Prediction of Biochemical Recurrence After Radical Prostatectomy Based on Preoperative 68Ga-PSMA-11 PET/CT
Authors: Qiu Xuefeng , Chen Mengxia , Yin Haoli , Zhang Qing , Li Haoyang , Guo Suhan , Fu Yao , Zang Shiming , Ai Shuyue , Wang Feng , Guo Hongqian 
Published: September 2021

PurposeThis study was designed to investigate the prognostic role of preoperative 68Ga-PSMA-11 PET/CT in predicting biochemical recurrence (BCR) of localized prostate cancer (PCa) after radical prostatectomy (RP).MethodsA total of 77 biopsy-confirmed PCa patients with 68Ga-PSMA-11 PET/CT prior to RP were included. A PSMA-ligand PET/CT-based risk model with SUVmax, maximum diameter of the index tumor and T stage was developed for prediction of 2-year BCR using Cox regression analysis. Also, the efficacy of the developed risk model was compared with European Association of Urology risk stratification (D’Amico) and the Cancer of the Prostate Risk Assessment (CAPRA) score. C-index and calibration plot were used to assess discrimination and calibration with internal validation.ResultsWith a median follow-up of 25 months, 23 (29.9%) patients experienced BCR within 2 years after RP. Patients experienced BCR had a significant higher PSA at diagnosis (p&lt;0.001), a higher ISUP grade of biopsy (p=0.044), as well as a higher ISUP grade (p=0.001), a higher possibility of T3 diseases (p=0.001) and positive margin (p=0.008) on postoperative pathology. SUVmax, maximum diameter of the index tumor and T stage on preoperative PSMA-ligand PET/CT were significantly associated with BCR (all p&lt;0.01). PSMA-ligand PET/CT-based risk model had a superior discrimination (c-index 78.5%) and good calibration at internal validation. The efficacy of this model in predicting 2-year BCR after RP was better, compared with CAPRA (c-index 66.3%) and D’Amico (c-index 66.2%). The addition of the PSMA-ligand PET/CT-derived variables also improved the efficacy of the existing models in predicting 2-year BCR (C-index of 78.9% for modified CAPRA and 79.3% for modified D’Amico, respectively).ConclusionA PSMA-ligand PET/CT-based risk model showed good efficacy in predicting 2-year BCR after RP, which needed to be validated by further prospective studies.
Choroid Plexus Carcinomas With TP53 Germline Mutations: Management and Outcome
Authors: Li Yanong , Liu Hailong , Li Tandy , Feng Jin , He Yanjiao , Chen Li , Li Chunde , Qiu Xiaoguang 
Published: September 2021

BackgroundChoroid plexus carcinomas (CPCs) are rare pediatric tumors commonly associated with Li-Fraumeni syndrome (LFS), which involves a germline mutation of the tumor suppressor gene TP53.Materials and MethodsWe retrospectively analyzed the corresponding information of 12 cases, including the effects of surgery and radiotherapy and TP53 germline mutations, to analyse the management strategies. Kaplan-Meier curves and the log-rank test were used to evaluate the progression-free survival (PFS).ResultsTwelve CPC patients were included, of which TP53 germline mutations were found in eight cases. All patients underwent surgical resection, and six patients received radiotherapy following with operation after initial diagnosis, one patient received radiotherapy following relapse. It was significantly different (P=0.012 and 0.028) that patients with TP53 germline mutation receiving the gross total resection (GTR) without radiotherapy showed survival advantages. Without TP53 germline mutations also showed survival advantages, but there is no statistical significance (P=0.063)ConclusionsThese findings provide evidence for the therapeutic strategy that radiotherapy should not be considered for patients with TP53 germline mutations.