bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ratio of von Willebrand factor antigen to ADAMTS13 activity is a useful biomarker for acute‐on‐chronic liver failure development and prognosis in patients with liver cirrhosis
Authors: Enomoto Masahide , Takaya Hiroaki , Namisaki Tadashi , Fujinaga Yukihisa , Nishimura Norihisa , Sawada Yasuhiko , Kaji Kosuke , Kawaratani Hideto , Moriya Kei , Akahane Takemi , Inoue Takashi , Matsumoto Masanori , Yoshiji Hitoshi 
Published: December 2021

AbstractAimAcute‐on‐chronic liver failure (ACLF) is associated with a high risk of short‐term mortality after progression to multiple organ failure. A disintegrin‐like and metalloproteinase with thrombospondin type‐1 motifs 13 (ADAMTS13) is a metalloproteinase that specifically cleaves multimeric von Willebrand factor (VWF). An imbalance between ADAMTS13 enzyme and VWF substrate is associated with liver cirrhosis progression that induces ACLF. This study examined the relationship between ADAMTS13 and VWF and ACLF development to determine whether ADAMTS13 and VWF are useful predictive biomarkers for ACLF development and prognosis of patients with liver cirrhosis.MethodsThe study enrolled 67 patients with Child–Pugh class A and B liver cirrhosis. ADAMTS13 activity (ADAMTS13:AC) and VWF antigen (VWF:Ag) were measured using enzyme‐linked immunosorbent assays. The ratio of VWF:Ag to ADAMTS13:AC (VWF:Ag/ADAMTS13:AC) was used to divide patients into two groups according to the classification and regression tree based on Gray model survival analysis.ResultsCompared with patients with Child–Pugh class A liver cirrhosis, class B patients had a higher VWF:Ag/ADAMTS13:AC and a higher risk of ACLF development. Cumulative incidence of ACLF was significantly higher in patients with high (>7.9) versus low (≤7.9) VWF:Ag/ADAMTS13:AC (hazard ratio [HR], 6.50; 95% CI, 2.31–18.29; p < 0.001). Cumulative survival was significantly lower in cirrhotic patients with high versus low VWF:Ag/ADAMTS13:AC (HR 5.11; 95% CI, 1.85–14.14; p = 0.002).ConclusionsFor patients with liver cirrhosis, VWF:Ag/ADAMTS13:AC is associated with functional liver reserve and predicts the development of ACLF and the prognosis.
Development of the HIV360 international core set of outcome measures for adults living with HIV: A consensus process
Authors: Marques‐Gomes João , Salt Matthew J. , Pereira‐Neto Rita , Barteldes Franca S. , Gouveia‐Barros Vera , Carvalho Alexandre , d’Arminio‐Monforte Antonella , De‐la‐Torre‐Rosas Alethse , Harris Amy , Esteves Catarina , Maor Carcom , Mora Cristina , Oliveira Carla , Sousa Cristina , Richman Douglas D. , Martinez Esteban , Cota‐Medeiros Fábio , Gramacho Filipa , Behrens Georg M. N. , Gonçalves Graça , Farinha Helena , Nabais Isabel , Vaz‐Pinto Inês , Sierra‐Madero Juan , Sousa‐Gago Joaquim , Thornhill John , Vera José , Erceg‐Tusek Maja , Tavares Margarida , Vasconcelos Miguel , Fernandes Nuno , Gianotti Nicola , Langebeek Nienke , Anjos Paulo , Couto Raquel , Fernandes Ricardo , Rajasuriar Reena , Serrão Rosário , Watson Shaun , Branco Teresa , Teixeira Tiago , Soriano Vicente 
Published: December 2021

AbstractObjectivesHIV outcomes centre primarily around clinical markers with limited focus on patient‐reported outcomes. With a global trend towards capturing the outcomes that matter most to patients, there is agreement that standardizing the definition of value in HIV care is key to their incorporation. This study aims to address the lack of routine, standardized data in HIV care.MethodsAn international working group (WG) of 37 experts and patients, and a steering group (SG) of 18 experts were convened from 14 countries. The project team (PT) identified outcomes by conducting a literature review, screening 1979 articles and reviewing the full texts of 547 of these articles. Semi‐structured interviews and advisory groups were performed with the WG, SG and people living with HIV to add to the list of potentially relevant outcomes. The WG voted via a modified Delphi process – informed by six Zoom calls – to establish a core set of outcomes for use in clinical practice.ResultsFrom 156 identified outcomes, consensus was reached to include three patient‐reported outcomes, four clinician‐reported measures and one administratively reported outcome; standardized measures were included. The WG also reached agreement to measure 22 risk‐adjustment variables. This outcome set can be applied to any person living with HIV aged > 18 years.ConclusionsAdoption of the HIV360 outcome set will enable healthcare providers to record, compare and integrate standardized metrics across treatment sites to drive quality improvement in HIV care.
The regulatory environment for migrant and women entrepreneurs
Authors: Ozasir‐Kacar Sibel , Essers Caroline 
Published: December 2021

AbstractThis study explores the impact of the underlying assumptions in the regulatory environments of two national contexts, Turkey and the Netherlands, on the entrepreneurship of Turkish women. It uses discourses on gender, ethnicity and entrepreneurship. The results indicate that these regulatory environments are immersed with male gendering ideology and give a secondary position to women and migrant entrepreneurs. Accordingly, women and migrant entrepreneurs are confined by the support provided to them by both governmental and non‐governmental organizations. Turkish women entrepreneurs are restricted in networking; access to institutions; and funding by the programmes, initiatives or regulations that their enterprises receive support from. This study contributes to existing literature on migrant and women entrepreneurship by discursively analysing underlying assumptions regarding these groups in two different national contexts.
Computational fluid dynamics and analytical modeling for predicting effects of airflow temperature and relative humidity on the terminal velocity of agricultural granular materials
Authors: Dousthaghi Mohammad Hadi , Minaei Saeid , Khoshtaghaza Mohammad Hadi 
Published: December 2021

AbstractThis study proposes a methodology based on computational fluid dynamics (CFD) for predicting the terminal velocity of agricultural granular materials in different airflow conditions that eliminates the need for extensive experiments. Terminal velocities of three seeds, namely chickpea, lentil, and rice, representing spherical, disc, and cylindrical seed shapes, respectively, were measured as a function of airflow temperature and relative humidity (RH) in an open‐circuit vertical wind tunnel. Experiments were carried out using a 3 × 3 factorial design in three replications. Terminal velocities of lentil and rice seeds varied from 4.73 to 5.67 m/s and 4.1 to 4.67 m/s, respectively, at 15–25°C and 20–80% RH. For chickpea seeds, terminal velocities varied from 8.8 to 9.43 m/s at 26–39°C and 20–60% RH. The effects of airflow temperature and RH on the terminal velocity of grains were significant at the 1% level. For all three grains, terminal velocity increased with temperature and RH. CFD‐predicted and theoretically calculated values of terminal velocity were compared with experimental results. Results of the statistical analysis showed that terminal velocities of lentil and chickpea calculated using analytical models were significantly higher than those obtained experimentally, whereas they were lower for rice seeds at the 5% level. The terminal velocity obtained through CFD simulations was in close agreement with the experimental results at the 1% level for lentil, chickpea, and rice seed at 5% level.Practical applicationsOne of the impressive factors of optimizing the loss of harvesting of cereals is the terminal velocity and its variation regarding the ambient conditions. Computational fluid dynamics is a validated method that can simulate the phenomenon and help us with a prediction of some characteristics. The results can be a basis for doing so in simulating the transfer of granular material in food processing devices.
PUB22 and PUB23 U‐box E3 ubiquitin ligases negatively regulate 26S proteasome activity under proteotoxic stress conditions
Authors: Ahn Min Yong , Seo Dong Hye , Kim Woo Taek 
Published: December 2021

SUMMARYThe mechanism regulating proteasomal activity under proteotoxic stress conditions remains unclear. Here, we showed that arsenite‐induced proteotoxic stress resulted in upregulation of Arabidopsis homologous PUB22 and PUB23 U‐box E3 ubiquitin ligases and that pub22pub23 double mutants displayed arsenite‐insensitive seed germination and root growth phenotypes. PUB22/PUB23 downregulated 26S proteasome activity by promoting the dissociation of the 19S regulatory particle from the holo‐proteasome complex, resulting in intracellular accumulation of UbG76V‐GFP, an artificial substrate of the proteasome complex, and insoluble poly‐ubiquitinated proteins. These results suggest that PUB22/PUB23 play a critical role in arsenite‐induced proteotoxic stress response via negative regulation of 26S proteasome integrity.
Plant target of rapamycin signaling network: Complexes, conservations, and specificities
Authors: Liu Yanlin , Xiong Yan 
Published: December 2021

AbstractTarget of rapamycin (TOR) is an evolutionarily conserved protein kinase that functions as a central signaling hub to integrate diverse internal and external cues to precisely orchestrate cellular and organismal physiology. During evolution, TOR both maintains the highly conserved TOR complex compositions, and cellular and molecular functions, but also evolves distinctive roles and strategies to modulate cell growth, proliferation, metabolism, survival, and stress responses in eukaryotes. Here, we review recent discoveries on the plant TOR signaling network. We present an overview of plant TOR complexes, analyze the signaling landscape of the plant TOR signaling network from the upstream signals that regulate plant TOR activation to the downstream effectors involved in various biological processes, and compare their conservation and specificities within different biological contexts. Finally, we summarize the impact of dysregulation of TOR signaling on every stage of plant growth and development, from embryogenesis and seedling growth, to flowering and senescence.
7T versus 3T MRI in the presurgical evaluation of patients with drug‐resistant epilepsy
Authors: Bubrick Ellen J. , Gholipour Taha , Hibert Matthew , Cosgrove G. Rees , Stufflebeam Steven M. , Young Geoffrey S. 
Published: December 2021

AbstractBackground and PurposeMRI has a crucial role in presurgical evaluation of drug‐resistant focal epilepsy patients. Whether and how much 7T MRI further improves presurgical diagnosis compared to standard of care 3T MRI remains to be established. We investigate the added value 7T MRI offers in surgical candidates with remaining clinical uncertainty after 3T MRI.Methods7T brain MRI was obtained on sequential patients with drug‐resistant focal epilepsy undergoing presurgical evaluation at a comprehensive epilepsy center, including patients with and without suspected lesions on standard 3T MRI. Clinical information and 3T images informed the interpretation of 7T images. Detection of a new lesion on 7T or better characterization of a suspected lesion was considered to add value to the presurgical workup.ResultsInterpretable 7T MRI was acquired in 19 patients. 7T MRI identified a lesion relevant to the seizures in three of eight patients (38%) without a lesion on 3T MRI; no lesion in 7/11 patients (64%) with at least one suspected lesion on 3T MRI, contributing to the final classification of all seven as nonlesional; and confirmed and better characterized the lesion suspected at 3T MR in the remaining 4/11 patients.Conclusions7T MRI detected new lesions in over a third of 3T MRI nonlesional patients, confirmed and better characterized a 3T suspected lesion in one third of patients, and helped exclude a 3T suspected lesion in the remainder. Our initial experience suggests that 7T MRI adds value to surgical planning by improving detection and characterization of suspected brain lesions in drug‐resistant focal epilepsy patients.
Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long‐COVID – A multinational ICOSS study
Authors: Merikanto Ilona , Dauvilliers Yves , Chung Frances , Holzinger Brigitte , De Gennaro Luigi , Wing Yun Kwok , Korman Maria , Partinen Markku ,   2nd ICOSS members
Published: December 2021

SummaryThis protocol paper describes the second survey produced by the International Covid Sleep Study (ICOSS) group with the aim to examine the associations between SARS‐CoV‐2 infection and sleep, sleepiness, and circadian problems as potential predisposing factors for more severe COVID‐19 disease profile and for development of Long‐COVID in the general population. The survey consists of 47 questions on sleep, daytime sleepiness, circadian rhythm, health, mental wellbeing, life habits, and socioeconomic situation before and during the pandemic, and conditional questions to those reporting having had coronavirus infection, being vaccinated, or suffering from particular sleep symptoms or sleep disorders. Surveys will be administered online between May and November 2021 in Austria, Brazil, Bulgaria, Canada, China, Croatia, Finland, France, Germany, Israel, Italy, Japan, Norway, Portugal, Sweden and USA. Data collected by the survey will give valuable information on the open questions regarding COVID‐19 disease risk factors, symptomatology and evolution of Long‐COVID, and on other long‐term consequences related to the pandemic.
Leadership styles' influence on ICU nurses' quality of professional life: A cross‐sectional study
Authors: Cosentino Chiara , De Luca Enrico , Sulla Francesco , Uccelli Stefano , Sarli Leopoldo , Artioli Giovanna 
Published: December 2021

AbstractBackgroundIntensive Care Units are emotionally intense environments where professional autonomy and interprofessional collaboration are essential. Nurses are at high risk of burnout, and the level of compassion satisfaction has a deep impact on the quality of their professional life. Although leadership styles and burnout have been the subject of an extensive body of research, there is an existing gap regarding the relationship between leadership strategies and intensive care nurses' quality of working life and the impact on their compassion satisfaction. Specifically, there is a lack of literature in southern European countries concerning the influence of organizational and cultural contexts.AimTo evaluate the impact of nurse managers' leadership styles on Intensive Care Unit nurses' job satisfaction and compassion satisfaction.DesignA cross‐sectional study.MethodsAn online set of validated tests was sent to a non‐probabilistic sample of nurses, recruited via the Italian association of intensive care and emergency nursing website. The set of tests consisted of the Empowering Leadership Questionnaire, Compassion Satisfaction Scale, and McCloskey Mueller Satisfaction Scale. Nurses actively working in intensive care and critical care settings were included in this study. ICU managers and leaders were excluded.Results308 nurses (response rate 63,2%) completed the questionnaires. Statistical analysis showed that the Leadership dimension of “Showing concern towards the team” had a significant effect on Compassion Satisfaction. In addition, this dimension had an effect on nurses' overall job satisfaction on five out of eight subscales.ConclusionsLeaders' authentic listening, communication, and participation capabilities have a positive impact on nurses' job and compassion satisfaction. The interest for team well‐being, taking time to discuss team concerns, and working closely with the team affects unpredicted factors like working hours, flexibility in shift scheduling, satisfaction about recognition, and career advancement.Relevance to clinical practiceResults suggest that nurse managers can draw on/adopt leadership strategies oriented to authentic listening and interaction with the team in order to manage organizational issues, increase nurses’ professional quality of life and prevent burnout.
Post‐operative anorectal manometry in children with Hirschsprung disease: A systematic review
Authors: Evans‐Barns Hannah M. E. , Swannjo Justina B. , Trajanovska Misel , Safe Mark , Hutson John M. , Dinning Phil G. , King Sebastian K. 
Published: December 2021

AbstractBackgroundHirschsprung disease is commonly encountered by pediatric surgeons. Despite advances in the surgical management, these children may experience symptoms of bowel dysfunction throughout adulthood. Anorectal manometry may be used to assess post‐operative anorectal structure and function. This review aimed to consolidate and evaluate the literature pertaining to post‐operative findings of anorectal manometry in children with Hirschsprung disease.Purpose(1) Synthesize the available data regarding anorectal motility patterns in children following repair of Hirschsprung disease. (2) Evaluate the reported anorectal manometry protocols.Data SourcesWe performed a systematic review of four databases: Embase, MEDLINE, the Cochrane Library, and PubMed.Study SelectionThis systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA). Studies reporting results of post‐operative anorectal manometry in children with Hirschsprung disease were evaluated for inclusion.ResultsTwenty‐three studies satisfied inclusion criteria, with a combined cohort of 939 patients. Post‐operative anorectal manometry results were reported for 682 children. The majority of included studies were assessed as “poor quality.” Disparate manometry protocols, heterogeneous cohorts, and lack of standardized outcome assessments introduced a risk of outcome reporting bias, limited the comparability of results, and impeded clinical translation of findings.ConclusionsThis systematic review demonstrated the lack of high‐quality evidence underlying the current understanding of post‐operative anorectal motility in children with HD. There was little consistency in reported manometry outcomes between studies. In future work, emphasis must be placed on the application of standardized manometry protocols, cohort reporting, and patient outcome assessments.
Wide complex tachycardia in a patient with non‐ischemic cardiomyopathy: What is the diagnosis?
Authors: Sriram Chenni S. , Gonzalez Mario D. 
Published: December 2021

AbstractA 55‐year‐old male presented with acute heart failure and incessant wide complex tachycardia resembling an outflow tract ventricular tachycardia. Meticulous analysis of the electrocardiograms established the diagnosis of pre‐excitation with prolonged atrio‐ventricular (A‐V) conduction over a decrementally conducting accessory A‐V pathway. “Linking” between the accessory A‐V pathway and normal A‐V conduction system resulted in sustained maximal pre‐excitation as well as periodic transition to normal A‐V conduction without appreciable change in heart rate. Successful radiofrequency ablation of this unusual accessory A‐V pathway was performed at the aortic‐mitral junction. This ameliorated the mechanical dysynchrony, allowed discontinuation of hemodynamic/inotropic support, and resulted in sustained symptomatic improvement.
New European Resuscitation Council guidelines for pediatric life support and their implications for pediatric anesthesia: An educational article
Authors: Buis Maria L. , Turner Nigel M. 
Published: December 2021

AbstractIn this educational article, we summarize the changes in the new European Resuscitation Council guidelines for Pediatric Life Support, emphasizing the most important aspects for the anesthesiologist. Among these are: the use of two‐thumb‐encircling technique for thorax compressions in infants, 10 ml/kg as the standard volume fluid bolus and ventilation after intubation at an age‐dependent rate. Using a fictitious case, we present a point‐by‐point summary of the changes and briefly mention some of the evidence behind them, referring the reader to the full guidelines for further evidence. We also give a summary of the incidence, causes, challenges, treatment, and prognosis of pediatric cardiac arrest in the operating room.
Two‐step irradiance schedule for condyloma acuminatum and the influencing factors of analgesic effect: A prospective randomized study
Authors: Qiao Shiyun , Qiao Shuyun , Jiang Guan 
Published: December 2021

AbstractBackgroundThe two‐step irradiance schedule in photodynamic therapy (PDT) is an emerging treatment method with a remarkable analgesic effect. We evaluated the influencing factors of pain in condyloma acuminate (CA) treatment with a two‐step irradiance schedule.MethodsAll patients were randomly divided into a two‐step irradiance group and control group. The two‐step irradiance group used 40 mW/cm2 for the first 8min, followed by 80 mW/cm2 for 16 min, while the control group used 80 mW/cm2 for 20 min. The Numerical Rating Scale (NRS) scores and pain‐influencing factors were recorded accordingly.ResultsIn the two‐step irradiance and control groups, 64 and 63 patients completed the treatment, respectively. The NRS scores of the two‐step irradiance group were significantly lower than that of the control group (p < .001), with a low fluence rate inducing less pain compared with a high fluence rate (p < .001). Moreover, when the total fluence accumulated to 57.6 J/cm2, the pain experienced by patients reached its peak. The NRS score of the urethral orifice group was the highest, and the male external genitalia group was the lowest. The NRS score was at its lowest in the first session and highest in the second session. There was a linear relationship between pain and wart size. Among these influencing factors, the fluence rate had the greatest impact on pain.ConclusionThe two‐step irradiance schedule provides better analgesic effects than standard treatment irradiation while showing similar treatment efficacy. Factors that influence pain include high fluence rate, CA at the urethral orifice, second therapy session, wart size, and the interval between CO2 laser and ALA‐PDT.
Association between first and second stage of labour duration and mode of delivery: A population‐based cohort study
Authors: Lundborg Louise , Åberg Katarina , Sandström Anna , Liu Xingrong , Tilden Ellen , Stephansson Olof , Ahlberg Mia 
Published: December 2021

AbstractBackgroundActive first stage of labour duration can widely vary between women. However, the nature of the relationship between the active first stage and second stage of labour duration is sparsely studied.ObjectivesTo determine whether active first stage of labour duration (i) influences second stage of labour duration; and (ii) is associated with mode of delivery.MethodsA population‐based cohort study of 13,379 women primiparous women, with spontaneous start in Stockholm‐Gotland Region, Sweden, between 2008 and 2014. Duration of the active first stage of labour was examined in relation to second‐stage duration using univariate and multivariable quantile regressions, with the first quartile (first stage duration) as the reference. Nonlinearity of associations was tested by restricted cubic splines. Association between active first‐stage duration with mode of delivery was estimated using a multinomial logistic regression based on adjusted odds ratios.ResultsLonger active first stage of labour duration was linearly associated with longer second stage of labour duration until approximately 12 h of active first stage of labour duration. After 12 h, a non‐linear trend is seen, demonstrated by a plateau in the second‐stage duration. In addition, longer active first stage of labour duration was associated with increased occurrence of operative vaginal delivery (adjusted odds ratio 3.36, 95% confidence interval [CI] 2.89, 3.89) and caesarean delivery (adjusted odds ratio 4.75, 95% CI 3.85, 5.80).ConclusionsAmong primiparous women with spontaneous onset of labour, longer active first stage of labour duration was associated with both longer second stage of labour duration and higher odds of operative delivery. This study contributes with findings, which may inform future discussions regarding how to properly account for second‐stage duration, with applications in obstetric and perinatal epidemiology.