bluuebunny/crossref_metadata_2025_split huggingface dataset:
The classical double copy for half-maximal supergravities and T-duality
Authors: Angus Stephen , Cho Kyoungho , Lee Kanghoon 
Published: October 2021

Abstract
We study the classical double copy for ungauged half-maximal supergravities using the Kaluza-Klein reduction of double field theory (DFT). We construct a general formula for the Kaluza-Klein (KK) reduction of the DFT Kerr-Schild ansatz. The KK reduction of the ansatz is highly nonlinear, but the associated equations of motion are linear. This linear structure implies that half-maximal supergravities admit a classical double copy. We show that their single copy is given by a pair of Maxwell-scalar theories, which are the KK reduction of a higher-dimensional single copy of DFT. We also investigate their T-duality transformations — both the Buscher rule and continuous O(D, D) rotations. Applying the Buscher rule to the Kerr BH, we obtain a solution with a nontrivial Kalb-Ramond field and dilaton. We also identify the single copy of Sen’s heterotic BH and the chiral null model and show that the chiral null model is self-dual under T-duality rotations.
Black hole entropy sourced by string winding condensate
Authors: Brustein Ram , Zigdon Yoav 
Published: October 2021

Abstract
We calculate the entropy of an asymptotically Schwarzschild black hole, using an effective field theory of winding modes in type II string theory. In Euclidean signature, the geometry of the black hole contains a thermal cycle which shrinks towards the horizon. The light excitations thus include, in addition to the metric and the dilaton, also the winding modes around this cycle. The winding modes condense in the near-horizon region and source the geometry of the thermal cycle. Using the effective field theory action and standard thermodynamic relations, we show that the entropy, which is also sourced by the winding modes condensate, is exactly equal to the Bekenstein-Hawking entropy of the black hole. We then discuss some properties of the winding mode condensate and end with an application of our method to an asymptotically linear-dilaton black hole.
First-generation new physics in simplified models: from low-energy parity violation to the LHC
Authors: Crivellin Andreas , Hoferichter Martin , Kirk Matthew , Manzari Claudio Andrea , Schnell Luc 
Published: October 2021

AbstractNew-physics (NP) constraints on first-generation quark-lepton interactions are particularly interesting given the large number of complementary processes and observables that have been measured. Recently, first hints for such NP effects have been observed as an apparent deficit in first-row CKM unitarity, known as the Cabibbo angle anomaly, and the CMS excess in$$ q\overline{q} $$qq¯→ e+e−. Since the same NP would inevitably enter in searches for low-energy parity violation, such as atomic parity violation, parity-violating electron scattering, and coherent neutrino-nucleus scattering, as well as electroweak precision observables, a combined analysis is required to assess the viability of potential NP interpretations. In this article we investigate the interplay between LHC searches, the Cabibbo angle anomaly, electroweak precision observables, and low-energy parity violation by studying all simplified models that give rise to tree-level effects related to interactions between first-generation quarks and leptons. Matching these models onto Standard Model effective field theory, we derive master formulae in terms of the respective Wilson coefficients, perform a complete phenomenological analysis of all available constraints, point out how parity violation can in the future be used to disentangle different NP scenarios, and project the constraints achievable with forthcoming experiments.
Accuracy and Prognostic Role of NCCT-ASPECTS Depend on Time from Acute Stroke Symptom-onset for both Human and Machine-learning Based Evaluation
Authors: Potreck A. , Weyland C. S. , Seker F. , Neuberger U. , Herweh C. , Hoffmann A. , Nagel S. , Bendszus M. , Mutke M. A. 
Published: October 2021

Abstract
Purpose
We hypothesize that the detectability of early ischemic changes on non-contrast computed tomography (NCCT) is limited in hyperacute stroke for both human and machine-learning based evaluation. In short onset-time-to-imaging (OTI), the CT angiography collateral status may identify fast stroke progressors better than early ischemic changes quantified by ASPECTS.

Methods
In this retrospective, monocenter study, CT angiography collaterals (Tan score) and ASPECTS on acute and follow-up NCCT were evaluated by two raters. Additionally, a machine-learning algorithm evaluated the ASPECTS scale on the NCCT (e-ASPECTS). In this study 136 patients from 03/2015 to 12/2019 with occlusion of the main segment of the middle cerebral artery, with a defined symptom-onset-time and successful mechanical thrombectomy (MT) (modified treatment in cerebral infarction score mTICI = 2c or 3) were evaluated.

Results
Agreement between acute and follow-up ASPECTS were found to depend on OTI for both human (Intraclass correlation coefficient, ICC = 0.43 for OTI < 100 min, ICC = 0.57 for OTI 100–200 min, ICC = 0.81 for OTI ≥ 200 min) and machine-learning based ASPECTS evaluation (ICC = 0.24 for OTI < 100 min, ICC = 0.61 for OTI 100–200 min, ICC = 0.63 for OTI ≥ 200 min). The same applied to the interrater reliability. Collaterals were predictors of a favorable clinical outcome especially in hyperacute stroke with OTI < 100 min (collaterals: OR = 5.67 CI = 2.38–17.8, p < 0.001; ASPECTS: OR = 1.44, CI = 0.91–2.65, p = 0.15) while ASPECTS was in prolonged OTI ≥ 200 min (collaterals OR = 4.21,CI = 1.36–21.9, p = 0.03; ASPECTS: OR = 2.85, CI = 1.46–7.46, p = 0.01).

Conclusion
The accuracy and reliability of NCCT-ASPECTS are time dependent for both human and machine-learning based evaluation, indicating reduced detectability of fast stroke progressors by NCCT. In hyperacute stroke, collateral status from CT-angiography may help for a better prognosis on clinical outcome and explain the occurrence of futile recanalization.
Der Weg zu Routinedaten aus 16 Notaufnahmen für die sektorenübergreifende Versorgungsforschung
Authors: Fischer-Rosinský Antje , Slagman Anna , King Ryan , Zimmermann Grit , Drepper Johannes , Brammen Dominik , Lüpkes Christian , Reinhold Thomas , Roll Stephanie , Keil Thomas , Möckel Martin , Greiner Felix ,   INDEED-Projekt, Behringer Wilhelm , Bernhard Michael , Blaschke Sabine , Busch Hans-Jörg , Erdmann Bernadett , Flasch Bernhard , Gries André , Höger-Schmidt Heike , Schöpke Timo , Schwarz Constanze , Somasundaram Rajan , Weidmann Erik , Wolfrum Sebastian , Wrede Christian 
Published: October 2021

Zusammenfassung
Hintergrund
In Deutschland gibt es bisher keine Gesundheitsberichterstattung zu sektorenübergreifenden Versorgungsverläufen im Kontext einer Notaufnahmeversorgung. Das Projekt INDEED (Inanspruchnahme und sektorenübergreifende Versorgungsmuster von Patienten in Notfallversorgungsstrukturen in Deutschland) erhebt Routinedaten aus 16 Notaufnahmen, die mit ambulanten Abrechnungsdaten der Jahre 2014 bis 2017 personenbezogen zusammengeführt werden.

Ziel der Arbeit
Die methodischen Herausforderungen der Planung der internen Zusammenführung von klinischen und administrativen Routinedaten aus Notaufnahmen in Deutschland bis zur finalen Datenextraktion werden hier gemeinsam mit Lösungsansätzen dargestellt.

Methodik
Die Auswahl der Notaufnahmedaten erfolgte in einem iterativen Prozess unter Berücksichtigung der Forschungsfragen, medizinischen Relevanz und angenommenen Datenverfügbarkeit. Nach einer Vorbereitungsphase zur Klärung der Rahmenbedingungen (u. a. Datenschutz, Ethik), zur Prüfung von Testdaten und ggf. Korrekturen, erfolgte die verschlüsselte und pseudonyme Datenausleitung.

Ergebnisse
Die Daten der 16 kooperierenden Notaufnahmen stammten in der Regel aus dem Notaufnahme- und dem Krankenhausinformationssystem. Die Datenlage war sehr heterogen. Nicht alle Variablen waren in jeder Notaufnahme verfügbar, da sie beispielsweise nicht standardisiert und digital vorlagen oder der Extraktionsaufwand als zu hoch bewertet wurde.

Schlussfolgerung
Relevante Daten aus Notaufnahmen liegen unterschiedlich strukturiert und in mehreren IT-Systemen vor. Die notwendige Bildung eines klinikübergreifenden vergleichbaren Datensatzes erfordert erhebliche Ressourcen auf Seiten der Kliniken sowie der datenaufbereitenden Stelle. Dies muss für zukünftige Projekte großzügig kalkuliert werden.
RDE research and development in Poland
Authors: Wolański P. 
Published: October 2021

AbstractA very short survey of research conducted in Poland on the development of the rotating detonation engine (RDE) is presented. Initial studies conducted in cooperation with Japanese partners lead to development of a joint patent on RDE. Then, an intensive basic and applied research was started at the Institute of Heat Engineering of the Warsaw University of Technology. One of the first achievements was the demonstration of performance of the rocket engine with an aerospike nozzle utilizing continuously rotating detonation (CRD), and research was directed into development of a small turbofan engine utilizing such a combustion regime. These activities promoted international cooperation and stimulated RDE development not only in Poland but also in other countries. A research directed to measure and calculate flow parameters as well as to analyze the use of liquid fuels was conducted. In the Institute of Aviation in Warsaw, research on the application of the CRD to turbine engines as well as rocket, ramjet, and combined cycle engines was carried out. In the paper, a special emphasis is given to international cooperation in this area with partners from many countries engaged in the development of the pressure gain combustion to propulsion systems.
Der (un)eingeschlagene Pfad
Authors: Portmann Edy 
Published: October 2021

ZusammenfassungIn einer ersten, durch den Physiker Freeman Dyson inspirierten „Common-Sense“ Kolumne vergleicht der Wirtschaftsinformatiker Edy Portmann die Geschichte von Analog- mit der von Digitalcomputer und fordert abschließend, mit einem gewagten Blick in die Zukunft, sein Schicksal als humanistischer Prophet heraus.
Diurnal cycle of precipitation and near-surface atmospheric conditions over the maritime continent: land–sea contrast and impacts of ambient winds in cloud-permitting simulations
Authors: Wei Yuntao , Pu Zhaoxia 
Published: October 2021

AbstractA set of cloud-permitting-scale numerical simulations during January–February 2018 is used to examine the diurnal cycle (DC) of precipitation and near-surface variables (e.g., 2 m temperature, 10 m wind and convergence) over the Indo-Pacific Maritime Continent under the impacts of shore-orthogonal ambient winds (SOAWs). It is found that the DC of these variables and their variabilities of daily maxima, minima, and diurnal amplitudes vary over land, sea, and coastal regions. Among all variables, the DC of precipitation has the highest linear correlation with near-surface convergence (near-surface temperature) over coastal (noncoastal) regions. The correlations among the DCs of precipitation, wind, and heating are greater over the ocean than over land. Sine curves can model accurately the DCs of most variables over the ocean, but not over land. SOAWs act to influence the DC mainly by affecting the diurnal amplitude of the considered variables, with DC being stronger under more strengthened offshore SOAWs, though variable dependence and regional variability exist. Composite analysis over Sumatra reveals that under weak SOAWs, shallow clouds are dominant and cause a pre-moistening effect, supporting shallow-to-deep convection transition. A sea breeze circulation (SBC) with return flow aloft can develop rapidly. Cold pools are better able to trigger new updrafts and contribute to the upscale growth and inland migration of deep convection. In addition, warm gravity waves can propagate upward throughout the troposphere, thereby supporting a strong DC. In contrast, under strong SOAWs, both shallow and middle-high clouds prevail and persist throughout the day. The evolution of moistening and SBC is reduced, leading to weak variation in vertical motion and rainwater confined to the boundary layer. Large-scale winds, moisture, and convection are discussed to interpret how strong SOAWs affect the DC of Sumatra.
Lessons learned from catheter ablation of ventricular arrhythmias in patients with a fully magnetically levitated left ventricular assist device
Authors: Bergau Leonard , Sommer Philipp , Hamriti Mustapha El , Morshuis Michel , Guckel Denise , Schramm René , Rojas Sebastian V. , Imnadze Guram , Gummert Jan F. , Sohns Christian , Fox Henrik 
Published: October 2021

Abstract
Introduction
Data on catheter ablation of ventricular arrhythmias (VA) are scarce in patients with left ventricular assist devices (LVADs) and current evidence predominantly consists of case reports with outdated LVAD. This prospective observational study reports our experience in terms of catheter ablation of VAs in patients with novel 3rd generation LVADs.

Methods and results
Between 2018 and 2020, nine consecutive patients undergoing a total number of ten ablation procedures for VAs were analyzed. The mean duration between LVAD implantation and catheter ablation was 23 ± 16 months. Acute procedural success was achieved in all patients. VA substrates were not related to the LVAD scarring (cannula) site in the majority of patients. All procedures were conducted without any relevant procedure-related complications. In terms of follow-up, only one patient presented with a repeat episode of electrical storm requiring ICD-shocks 16 months after the initial ablation procedure. Four patients suffered of singular VA effectively treated with antitachycardia pacing via their ICD. The remainder were free of any VA relapse (n = 4). Two non-procedure-related deaths occurred during follow-up.

Conclusions
Catheter ablation of VAs in patients with 3rd generation LVAD is feasible and leads to satisfying clinical results in terms of freedom from VA recurrence and quality of life. The majority of arrhythmia substrates in these patients are not directly related to the LVAD cannulation site and may represent a progress of heart failure.

Graphic abstract
Patients’ attitude towards a sham-controlled trial on pulmonary vein isolation in atrial fibrillation
Authors: Uhe Tobias , Beimel Samira , Langhammer Romy , Stegmann Tina , Hindricks Gerhard , Laufs Ulrich , Dagres Nikolaos , Wachter Rolf 
Published: October 2021

Abstract
Background
The interpretation of recent trials on pulmonary vein ablation (PVI) for the treatment of atrial fibrillation (AF) is hampered by the lack of blinding and sham controls. The feasibility of a sham-controlled trial has been questioned. We aimed to assess the attitude of potential participants regarding a sham-controlled trial in a common AF-patient population planned for PVI.

Methods
Patients in two tertiary care centres planned for PVI were asked for their current AF symptoms using the Atrial Fibrillation Effect on QualiTy of Life (AFEQT) questionnaire 1 day before catheter ablation. Subsequently, the study design of a hypothetical sham-controlled PVI-study was introduced, and patients were asked for their agreement in participation. Telephone follow-up of the AFEQT questionnaire was conducted 3 months after PVI.

Results
One hundred and ninety-six patients (mean age 64 ± 11 years, 63% male) were included. Seventy-nine (40%) patients expressed their agreement to participate in the hypothetical sham-controlled trial. An additional 7% agreed to participate if a cross-over option after three months was offered. Agreement rate was similar in patients with first and Redo-PVI and minimal, moderate or severe symptoms. Mean overall AFEQT at baseline was 55 ± 19 and improved by 25 ± 20 points after 3 months (p < 0.001 versus baseline).

Conclusion
With a participation rate of 40% in potential study participants, a sham-controlled trial for pulmonary vein isolation seems feasible. Patient-reported symptom relief after pulmonary vein isolation is in accordance with previous randomized open studies. The benefit of PVI should be rigorously evaluated in a sham-controlled trial.

Graphic abstract
Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn
Authors: Clemens A. C. , Loeffler K. U. , Holz F. G. , Herwig-Carl M. C. 
Published: October 2021

Abstract

Purpose
The lacrimal caruncle is composed of numerous structures including different glands as well as hair follicles. Accordingly, the spectrum of benign and malignant lesions is broad, and the clinical diagnosis is often challenging. Here we systematically analyzed excised caruncular tumors over the past 22 years with special emphasis on the clinico-pathological correlation to provide a guidance for clinicians.

Methods
Retrospective evaluation with clinico-pathologic correlation of surgically removed caruncular tumors between 1998 and 2020 at a tertiary referral center.

Results
Eighty-two caruncular tumors were identified in the respective period. The patients were between 11 and 85 years of age (mean, 46.8 years; median, 49 years). Nevi (n = 35), cystic lesions (n = 14), oncocytoma (n = 9), papilloma (n = 8), sebaceous gland hyperplasia (n = 8), and reactive lymphoid hyperplasia (n = 4) were observed most frequently. Besides, we are the first reporting herniated orbital fat accompanied by a pyogenic granuloma. 2.4% (n = 2) were malignant tumors (sebaceous gland carcinoma, conjunctival intraepithelial neoplasia with pyogenic granuloma).

Conclusion
Caruncular tumors show a broad spectrum of mostly benign tumors. They can occur in patients of any age. However, 8/9 oncocytomas and both malignant lesions were detected in patients older than 60 years. Although the clinical diagnosis was confirmed in only 68.3% by the histopathological analysis, the two malignant lesions were identified as such already clinically. Caruncular lesions with a history of growth or other signs of malignancy should be excised followed by detailed histopathological examination to allow a final diagnosis and exclude rare malignant tumors with lethal potential.
The population genetics characteristics of a 90 locus panel of microhaplotypes
Authors: Pakstis Andrew J. , Gandotra Neeru , Speed William C. , Murtha Michael , Scharfe Curt , Kidd Kenneth K. 
Published: October 2021

AbstractSingle-nucleotide polymorphisms (SNPs) and small genomic regions with multiple SNPs (microhaplotypes, MHs) are rapidly emerging as novel forensic investigative tools to assist in individual identification, kinship analyses, ancestry inference, and deconvolution of DNA mixtures. Here, we analyzed information for 90 microhaplotype loci in 4009 individuals from 79 world populations in 6 major biogeographic regions. The study included multiplex microhaplotype sequencing (mMHseq) data analyzed for 524 individuals from 16 populations and genotype data for 3485 individuals from 63 populations curated from public repositories. Analyses of the 79 populations revealed excellent characteristics for this 90-plex MH panel for various forensic applications achieving an overall average effective number of allele values (Ae) of 4.55 (range 1.04–19.27) for individualization and mixture deconvolution. Population-specific random match probabilities ranged from a low of 10–115 to a maximum of 10–66. Mean informativeness (In) for ancestry inference was 0.355 (range 0.117–0.883). 65 novel SNPs were detected in 39 of the MHs using mMHseq. Of the 3018 different microhaplotype alleles identified, 1337 occurred at frequencies > 5% in at least one of the populations studied. The 90-plex MH panel enables effective differentiation of population groupings for major biogeographic regions as well as delineation of distinct subgroupings within regions. Open-source, web-based software is available to support validation of this technology for forensic case work analysis and to tailor MH analysis for specific geographical regions.
The relationship between quotas and harvest in the alpine reindeer population on Hardangervidda, Norway
Authors: Mysterud Atle , Viljugrein Hildegunn , Lund Jan Henning L’Abée , Lund Svein Erik , Rolandsen Christer M. , Strand Olav 
Published: October 2021

AbstractHunting of cervids is commonly regulated by quotas that are specific to sex and age groups. There is substantial cultural variation in how quotas are regulated. In Scandinavia, the entire quotas are often not shot making deer management potentially less predictable. However, the effect of quota size and demographic composition on harvest offtake by recreational hunters has, to a limited extent, been empirically investigated in Scandinavia. Hunters are limited by time and opportunity and may not respond to changes in quota, as anticipated by managers. We analysed the variation in the proportion of quotas filled depending on quota size relative to population size and demographic composition of quotas during the period of 1986–2019 involving a population size varying from approximately 5000 to 15,000 reindeer on Hardangervidda, Norway. We found that the proportion of quota being filled by hunters varied substantially (12–48%) on an annual basis. The quota occasionally exceeded the estimated population size, but the proportion of the quota filled increased the higher the population size was relative to the quota size. The proportion of quota being filled by hunters was markedly lower for calf licences. High annual variation in the proportion of quota being filled by hunters causes considerable implementation uncertainty when managers aim to regulate cervid populations. Nevertheless, there was a strong correlation between quota size and harvest size. Facing new management requirements, a harvest rate of ~ 47% of the adult male population size was achieved in 2019, compared to an average of 16%. Hence, managers compensated for the low proportion of quota being filled by increasing quotas to reach target harvesting aims, but there remains a limit as to how precisely such a wide-ranging reindeer population can be regulated using recreational hunters.
Impact of the first wave of COVID-19 pandemic on the Hungarian university students’ social and health behaviour
Authors: Csépe Péter , Dinya Elek , Balázs Péter , Hosseini Shahrokh Mirza , Küzdy Gábor , Rosivall László 
Published: October 2021

Abstract
Background
The COVID-19 pandemic brought quick, severe and unexpected changes to our everyday life and also changed the traditional education pattern of Semmelweis University in the middle of academic year 2019–2020. We explored adaptive changes in Hungarian students’ behaviour and their time-budget in order to determine whether quarantine and/or fear of infection were responsible for these changes.

Methods
A self-administered online questionnaire was distributed to all students in the Hungarian language program (N = 7436) of Semmelweis University. Information was collected on basic demographic data, knowledge and attitude about COVID-19, methods of prevention as well as the students’ behaviour before, during and after the first wave of the pandemic. Statistical analyses were processed using the IBM-SPSS 25.0 software package.

Results
The overall response rate was 11% (N = 816). Only complete responses were processed (55%, N = 447). Among these responders, 83% did not fear the pandemic. Those who greatly feared COVID-19 infection strictly kept all regulations. The number of non-smokers increased by the end of the first wave. The nutrition of 100 students (21%) became healthier and the lockdown reduced the level of physical activity.

Conclusion
Social and health-related behaviour of medical students changed basically during the first wave of the pandemic and some changes remained after it in tobacco smoking, nutrition and sleeping habits. Time-budget of students changed significantly during the pandemic and did not return to the baseline values. Results of this study justify future multiple systematic research to analyse and better understand the short- and long-term effects of the current crisis.