bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐World Guselkumab Response and Drug Survival in Australian Patients With Psoriasis: Results From the Australasian Psoriasis Registry
Authors: Manuelpillai Nicholas , Armstrong Julie , Ismail Fathima Ferial , Vogrin Sara , Maranta Debra , Puig Andrea , Radulski Barbara , Kern Johannes S. , Baker Christopher S. , Foley Peter 
Published: December 2024

Aims: Guselkumab’s real‐world efficacy, drug survival, and patient characteristics from the Australasian Psoriasis Registry (APR) were compared with the data from the Phase III VOYAGE 1 trial.Methods: Data from patients with severe plaque psoriasis prescribed guselkumab through the Australian Pharmaceutical Benefits Scheme (PBS) were derived from the APR. Demographic and treatment data (including psoriasis area and severity index [PASI]) at defined timepoints from 4th September 2018 to 1st October 2022 were analyzed. The baseline was PASI at the commencement of the first biologic. APR and VOYAGE 1 data were compared using 2‐sample t‐tests and chi‐square tests. Associations between patient characteristics and drug survival/time to PASI score were assessed using Cox proportional hazards regression and Kaplan–Meier estimates.Results: 102 patients were eligible; 87.3% (n = 89) had received prior biologic therapy versus 21.6% patients in VOYAGE 1. Overall drug survival in APR was 99.0%, 93.1%, 83.3% and 77.1% at 3, 9, 15, and 27 months, respectively. At 9 months, drug survival was 100% for bionaïve and 92.1% for bioexperienced patients. In VOYAGE 1, 91.5% continued guselkumab through Week 48 (∼11 months). In the APR, the median PASI was 24.0 (IQR: 17.9–32.2) at baseline, and 1.1 (IQR: 0–2.7) at 9 months. Absolute PASI ≤ 3 and PASI90 were attained by 73.8% and 64.8%, respectively. In VOYAGE 1, 76.3% reached PASI90 at Week 48. Bionaïve patients in the APR had longer drug survival than bioexperienced.Conclusions: Guselkumab was efficacious in the real‐world treatment of psoriasis, consistent with RCT results. Drug retention rates were high through 27 months, despite a higher proportion of bioexperienced patients in the APR than in VOYAGE 1.
FDA Approval Summary: Nadofaragene Firadenovec-vncg for Bacillus Calmette–Guérin–Unresponsive Non–Muscle-Invasive Bladder Cancer
Authors: Colbert Laronna , Jia Yuxia , Sharma Anurag , Hu Jiang , Xu Zhenzhen , Suzman Daniel L. , Das Asha , Bross Peter , Kluetz Paul G. , Fashoyin-Aje Lola A. 
Published: December 2024

Abstract
On December 16, 2022, the FDA approved the adenoviral vector–based gene therapy nadofaragene firadenovec-vncg (brand name Adstiladrin) for the treatment of adult patients with high-risk Bacillus Calmette–Guérin (BCG)-unresponsive non–muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS). The product represents the first approved adenoviral vector–based gene therapy and the first approved gene therapy for bladder cancer. Determination of efficacy was based on results from Study rAd-IFN-CS-003 (Study CS-003), a single-arm trial in 98 evaluable patients with BCG-unresponsive NMIBC with CIS who received intravesical instillations of the gene therapy product (75 mL of nadofaragene firadenovec at 3 × 1011 viral particles per mL) once every 3 months. The major efficacy outcome measures were complete response (CR) at any time and duration of response. Fifty subjects experienced CR 3 months after the initial treatment (CR = 51%; 95% confidence interval, 40.7; 61.3%), of whom 46% remained in response for ≥12 months. The median duration of response was 9.7 months (range: 3–52+). Common adverse reactions included instillation site discharge, fatigue, bladder spasm, micturition urgency, hematuria, chills, pyrexia, and dysuria. The approval of nadofaragene firadenovec provides a new therapy option for patients with BCG-unresponsive NMIBC with CIS who are ineligible for cystectomy.
Macrophage Ferroptotic Resistance Is Required for the Progression of Infantile Hemangioma
Authors: Liu Jingjing , Zhong Wenqun , Wang Rong , Wang Peipei , Tong Guoyong , Chai Maosheng , Sun Yu , Zhu Tianshuang , Huang Congfa , Yang Shaodong , Zhou Xiaoshun , Mou Dongsheng , Cai Yu 
Published: December 2024

Background
Ferroptosis is a programmed cell death caused by iron‐dependent accumulation and cellular lipid peroxides, which is different from apoptosis and pyroptosis. This study investigated the possible effect of ferroptotic response in the pathogenesis of infantile hemangioma (IH).

Methods and Results

The staining level of 4‐hydroxynonenal (4‐HNE), the marker of ferroptotic cells, was significantly increased in the involutive IH samples compared with the proliferative samples (9 proliferative versus 12 involutive lesions,
P
=0.0152). By contrast, the expression of glutathione peroxidase 4 (GPX4), a key enzyme regulating ferroptotic resistance, was significantly increased in the involutive IH samples. Meanwhile, the GPX4 was richly expressed in macrophages of IH. The data from in vitro study showed that the mRNA (
P
=0.0002) and protein (
P
=0.0385) expression levels of GPX4 were significantly upregulated in macrophages cultured with hemangioma‐derived stem cells conditional medium (HemSC‐CM). Mechanistically, HemSC‐CM promoted the expression of GPX4 in macrophages (
P
=0.0482) by increasing nuclear factor erythroid 2‐related factor 2 translocation to the nucleus (
P
=0.0026). Additionally, inhibition of GPX4 or inducing ferroptosis in macrophages could inhibit progression of lesion in IH nude mice mode.

CONCLUSIONS
Hemangioma‐derived stem cells (HemSCs) could promote macrophage ferroptotic resistance through upregulating expression of GPX4, which is required for the progression of IH.
Hemodynamic Characteristics and Prognostic Implication of Modified Society for Cardiovascular Angiography and Interventions Shock Classification in Comatose Patients With Out‐of‐Hospital Cardiac Arrest
Authors: Linde Louise , Beske Rasmus P. , Meyer Martin A. S. , Mølstrøm Simon , Grand Johannes , Helgestad Ole K. L. , Ravn Hanne B. , Schmidt Henrik , Kjærgaard Jesper , Hassager Christian , Møller Jacob E. 
Published: December 2024

Background
Cardiogenic shock complicating acute myocardial infarction is associated with a high mortality rate. Cardiogenic shock after out‐of‐hospital cardiac arrest (OHCA) can be due to transient myocardial stunning but also reflect the increasing severity of ongoing heart failure. The Society for Cardiovascular Angiography and Interventions (SCAI) proposed a division of cardiogenic shock into 5 phenotypes, with cardiac arrest being a modifier. The objective was to apply SCAI shock classification to a well‐characterized OHCA population and describe the hemodynamic characteristics and prognostic significance of increasing SCAI classes.

Methods and Results

This is a post hoc analysis of data from the BOX (Blood Pressure and Oxygenation Targets in Post Resuscitation Care) trial of comatose patients with OHCA. Patients were classified according to SCAI class upon hospital admission. Invasive arterial and pulmonary arterial measurements were obtained the first 72 hours after admission, and perfusion pressure, cardiac index and cardiac power output were calculated. Of 789 patients included, 31.6% were classified as SCAI class B/C, 29.9% as SCAI class D, and 38.5% as SCAI class E. The first recorded perfusion pressure differed between SCAI class B/C, D, and E being lower in higher SCAI classes. The difference was found only at the first measurement. Cardiac index and cardiac power output did not differ at any time point between classes. The 1‐year mortality rate increased with SCAI Class B/C to E (21.3%, 34.3%, and 48.4%, respectively;
P
<0.001).

Conclusions
The 1‐year mortality rate after OHCA increased with increasing SCAI classes, but cardiac index, cardiac power output, and perfusion pressure remained notably similar in the first 72 hours after admission. This challenges whether all OHCAs should be recorded as SCAI class E by default.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03141099.
Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial
Authors: Siddiqi A. Zohaib , Ignacio Katrina , Kaveeta Chitapa , Bala Fouzi , Ademola Ayoola , Tkach Aleksander , Buck Brian H. , Catanese Luciana , Hunter Gary , Dowlatshahi Dar , Shamy Michel , Zafar Atif , Field Thalia S. , Appireddy Ramana , Wadhwa Ankur , Sajobi Tolulope , Swartz Rick , Almekhlafi Mohammed , Demchuk Andrew , Menon Bijoy , Singh Nishita 
Published: December 2024

Background
About 25% of patients with acute ischemic stroke have lacunar infarct on follow‐up imaging. In this secondary analysis from the AcT (Alteplase Compared With Tenecteplase) trial, we assessed if there is variation in safety or efficacy of intravenous thrombolysis by infarct type in patients with no visible occlusion. We also determined if this effect differed between tenecteplase and alteplase.

Methods and Results
This is a secondary analysis from the AcT trial. Lacunar infarct was defined as single, ≤15 mm, and in regions supplied by perforating arterioles on 24‐hour imaging. Outcomes included symptomatic intracerebral hemorrhage at 24 hours, any hemorrhage on imaging, and 90‐day modified Rankin Scale score. Mixed‐effects regression models adjusted for age, sex, stroke severity, thrombolytic type, and onset‐to‐needle time were used. Of 1577 patients, 456/29.9% had no visible occlusion and interpretable follow‐up imaging (magnetic resonance imaging: 41.2%). Of these 93 (20.4%) (magnetic resonance imaging: 62.3%) had lacunar infarct, 171 (37.5%) (magnetic resonance imaging: 67.4%) had nonlacunar infarct, and 192 (42.1%) (magnetic resonance imaging: 7.3%) had no visible infarct. Four patients (2.3%) in the group with nonlacunar infarct and none in the groups with lacunar infarct and no visible infarct developed symptomatic intracerebral hemorrhage. Any intracranial hemorrhage was highest (21; 12.4%) in the group with nonlacunar infarct. There was no significant interaction between thrombolytic type and treatment outcomes.

Conclusions
In the AcT trial, safety of intravenous thrombolysis was similar across all infarct types in patients with no visible occlusion but functional outcomes were worst in patients with nonlacunar infarct. Safety and functional outcomes after intravenous thrombolysis were better in the groups with lacunar infarct and no visible infarct as compared with the overall trial population.
Myocardial Infarction Injury Is Exacerbated by Nicotine in Vape Aerosol Exposure
Authors: Savko Clarissa , Esquer Carolina , Molinaro Claudia , Rokaw Sophie , Shain Abraham G. , Jaafar Faid , Wright Morgan K. , Phillips Joy A. , Hopkins Tyler , Mikhail Sama , Rieder Abigail , Mardani Ariana , Bailey Barbara , Sussman Mark A. 
Published: December 2024

Background
Vaping is touted as a safer alternative to traditional cigarette smoking, but the full spectrum of harm reduction versus comparable risk remains unresolved. Elevated bioavailability of nicotine in vape aerosol together with known risks of nicotine exposure may result in previously uncharacterized cardiovascular consequences of vaping. The objective of this study is to assess the impact of nicotine exposure via vape aerosol inhalation upon myocardial response to infarction injury.

Methods and Results
Flavored vape juice containing nicotine (5 mg/mL) or vehicle alone (0 mg) was delivered using identical 4‐week treatment protocols. Mice were subjected to acute myocardial infarction injury and evaluated for outcomes of cardiac structure and function. Findings reveal that nicotine exposure leads to worse outcomes with respect to contractile performance regardless of sex. Nonmyocyte interstitial cell accumulation following infarction significantly increased with exposure to vape aerosol alone, but a comparable increase was not present when nicotine was included.

Conclusions
Myocardial function after infarction is significantly decreased after exposure to nicotine vape aerosol irrespective of sex. Comparable loss of contractile function was not observed in mice exposed to vape aerosol alone, highlighting the essential role of nicotine in loss of contractile function. Increased vimentin immunoreactivity was observed in the vape alone group compared with control and vape nicotine. The correlation between vaping, interstitial cell responses, and cardiac remodeling leading to impaired contractility warrants further investigation. Public health experts seeking to reduce vaping‐related health risks should consider messaging that highlights the increased cardiovascular risk especially with nicotine‐containing aerosols.
Transcranial Cortex-Wide Imaging of Murine Ischemic Perfusion With Large-Field Multifocal Illumination Microscopy
Authors: Chen Zhenyue , Zhou Quanyu , Droux Jeanne , Liu Yu-Hang , Glück Chaim , Gezginer Irmak , Wyss Matthias , Yoshihara Hikari A.I. , Kindler Diana Rita , Weber Bruno , Wegener Susanne , El Amki Mohamad , Razansky Daniel 
Published: December 2024

BACKGROUND:
Ischemic stroke is a common cause of death worldwide and a main cause of morbidity. Presently, laser speckle contrast imaging, x-ray computed tomography, and magnetic resonance imaging are the mainstay for stroke diagnosis and therapeutic monitoring in preclinical studies. These modalities are often limited in terms of their ability to map brain perfusion with sufficient spatial and temporal resolution, thus calling for development of new brain perfusion techniques featuring rapid imaging speed, cost-effectiveness, and ease of use.

METHODS:
We report on a new preclinical high-resolution angiography technique for murine ischemic stroke imaging based on large-field high-speed multifocal illumination fluorescence microscopy. We subsequently showcase the proposed method by monitoring therapeutic effects of thrombolysis in stroke (n=6), further performing cross-strain comparison of perfusion dynamics (n=6) and monitoring the therapeutic effects of sensory stimulation–based treatment (n=11).

RESULTS:
Quantitative readings of hemodynamic and structural changes in cerebral vascular network and pial vessels were attained with 14.4-µm spatial resolution at 80-Hz frame rate fully transcranially. The in vivo perfusion maps accurately delineated the ischemic core and penumbra, further exhibiting a strong correlation (86.1±4.5%) with ex vivo triphenyl tetrazolium chloride staining, significantly higher than for the conventional laser speckle contrast imaging method. Monitoring of therapeutic effects of thrombolysis confirmed that early recanalization could effectively save the penumbra while reducing the infarct area. Cross-strain comparison of perfusion dynamics affirmed that C57BL/6 mice feature a larger penumbra and smaller infarct core as compared with BALB/c mice, which have few or no collaterals. Sensory stimulation–based treatment could effectively enhance blood flow and abolish perfusion deficits in the ischemic core and penumbra regions.

CONCLUSIONS:
A high-speed fluorescence-based angiography method for transcranial stroke imaging in mice is introduced, which is capable of localizing brain perfusion changes and accurately assessing the ischemic penumbra. Compared with the whole-brain x-ray computed tomography and magnetic resonance imaging methods, which are conventionally used for stroke diagnosis and therapeutic monitoring, the new approach is simple and cost-effective, further offering high resolution and speed for in vivo studies. It thus opens new venues for brain perfusion research under various disease conditions such as stroke, neurodegeneration, or epileptic seizures.
Climata et temperamenta: the Influence of Climate and Environment on Human Complexion in the Thirteenth and Fourteenth Centuries
Authors: Miteva Evelina 
Published: December 2024

Abstract
The present paper addresses the way in which local conditions – geographical, biological or astrological – were believed to influence the general constitution of human nature from the viewpoint of natural philosophy. What were the material conditions that constituted the diversity between peoples and individuals? The focus of this paper is on the relation between climatic zones and the complexion of their inhabitants. This relation and the ensuing natural determinism are present in Albert the Great’s De natura loci. While not being as specific as Albert in laying out the ethnographic specifics, Thomas Aquinas shared the general framework set out by his teacher that astrological and geographical conditions greatly affect the complexion of the inhabitants. In his unedited commentary on Aristotle’s Parva naturalia, John Buridan sticks to the general Aristotelian paradigm, to which Albert and Thomas also adhered, but considers in greater detail the way climatic conditions affect the individual human complexion.
Observations on the Verb Morphology of the Language of the “Amorite-Akkadian Bilinguals”
Authors: Arkhipov Ilya , Loesov Sergey 
Published: December 2024

Abstract
The left column of the newly published “Amorite-Akkadian bilinguals” contains words and sentences in a heretofore unknown Northwest Semitic language, with an Old Babylonian translation. The present study compares the verb morphology of this language with those of Biblical Hebrew and various Aramaic languages.
Conversion Narratives as Mirrors of Religious Encounters
Authors: Bornet Philippe 
Published: December 2024

Abstract
This article focuses on the narratives that emerged from two conversion episodes in Kerala in the 1920s involving the German missionary Paul Sengle (1870–1932): the conversion of a young Hindu woman named Kalyani and attempts to convert members of the Ezhava caste amid competition from Hindus, Muslims, and Buddhists. While mainly drawing on materials produced by the Basel Mission or by missionaries in the field like Sengle, this article also gives space to the perspectives of the newly converted person and of the rival religious communities. It suggests studying conversion experiences as shaped by situations of interaction, by connecting sources that represent the divergent perspectives of all the parties involved in such cases. This approach helps to examine the different sides of a conversion experience at both macro and micro levels and offers insights into the broader processes of religious encounters in the early twentieth century global history of religions.
Black History in the Chinese Imagination: From Maoist Revolution to Deng Xiaoping’s Reforms, 1964–1989
Authors: Barnes Melvin 
Published: December 2024

Abstract
This article examines Chinese interpretations of the Black experience in the United States and maps its evolution from 1964 to 1989. It argues that the transition of the People’s Republic of China (prc) from a revolutionary socialist state under Mao Zedong in the 1960s to a socialist state focused on implementing Deng Xiaoping’s socioeconomic reforms in the 1980s necessitated a reimaging of the prc’s engagement with African Americans. Western literature on the prc’s engagement with African Americans has focused primarily on Mao’s China between 1949 and 1976. The aim of this article is to examine Chinese engagement with Black history and African Americans into the Reform Era to contribute to this body of literature. By bridging the 1976 divide, it offers a novel interpretation that demonstrates how accelerated international exchanges and the prc’s domestic reforms defined Sino-African American engagement.
Advocating for the Civil Rights of Japanese Americans at the Incarceration Camps
Authors: Iwai Shuma 
Published: December 2024

Abstract
Galen Merriam Fisher was one of the few White American activists protesting for the civil rights of Japanese Americans during World War ii. Japan’s attack on Pearl Harbor brought the United States into World War ii in December 1941. Prioritizing national security, President Franklin D. Roosevelt issued the Executive Order 9066 in February 1942. It called for the exile of Japanese Americans to incarceration camps without trials or hearings, where they experienced racial discrimination, prejudice, and unequal treatment. This article examines Fisher’s activism on behalf of Japanese Americans. As a former long-time missionary in Japan, he consistently voiced his concerns about maltreatment of Japanese Americans to the U.S. federal authorities and the public. While offering detailed historical context, this study carefully analyzes Fisher’s arguments about the violation of constitutional rights, harsh treatment, and racial discrimination at the camps, and for early release of Japanese Americans. It will support historians, Asianists, and scholars of Asian American studies because it offers a model to advocate against injustices and for civil rights, which one can apply to other similar historical and/or current contexts.
Emil Lasks Auslegung der Wissenschaftslehre
Authors: Ferraguto Federico 
Published: December 2024

Zusammenfassung
Dieser Aufsatz untersucht Emil Lasks kritische Auseinandersetzung mit der Philosophie Johann Gottlieb Fichtes, insbesondere bezüglich der Konzeptualisierung von Irrationalität und Realität im Rahmen der transzendentalen Philosophie. Lask interpretiert Fichtes Ansatz zu Wissen und Realität durch eine einzigartige Perspektive und vertritt die Ansicht, dass die Realität, obwohl sie jenseits des Wissens existiert, dieses von einer externen, doch integralen Perspektive aus formt. Diese Interaktion spiegelt eine fundamentale Irrationalität wider, die dem Ursprung des Wissens innewohnt und empirische Grenzen übersteigt. Der Aufsatz hebt hervor, wie Fichte und Lask die traditionellen Grenzen des Rationalismus und Realismus herausfordern, indem sie ein dynamisches Zusammenspiel zwischen dem Rationalen und dem Irrationalen vorschlagen. Lasks Analyse belebt nicht nur Fichtes Ideen neu, sondern leistet auch einen bedeutenden Beitrag zur aktuellen Debatte über Realismus, indem sie für ein philosophisches Verständnis wirbt, das die nicht-empirischen Dimensionen der Realität und ihre wertgetriebenen Implikationen berücksichtigt.
Fichte et le problème de la rationalité juridique
Authors: Guyot Laurent 
Published: December 2024

Resumé
On a coutume de considérer qu’il y a un revirement complet qui s’opère chez Fichte entre ses Considérations sur la Révolution française de 1793 et son Fondement du droit naturel de 1796 en vertu de ce que le droit naturel et la morale ne sont pas dissociés dans la première œuvre et le deviennent complètement dans la seconde. Sans doute, le droit naturel est bien posé en 1793 comme l’expression de la loi morale dans les phénomènes, au lieu qu’il est affirmé comme une science distincte de la morale en 1796. Il y aurait donc là une évolution bien connue de sa philosophie et non un problème. Pourtant, c’est faire fi de la complexité de la rationalité juridique chez Fichte que de s’en tenir à une simple lecture discontinuiste. Cet article voudrait montrer que ces deux œuvres que l’on oppose traditionnellement ne représentent pas deux visions inconciliables de la rationalité juridique, mais plutôt deux aspects complémentaires de la même rationalité juridique. En effet, selon que le Moi est pris sous le rapport de sa destination ou de sa genèse, deux perspectives différentes mais conciliables s’ouvrent sur le droit.