bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating collaborations between researchers and practitioners in ecosystem management and restoration
Authors: Jellinek Sacha , Lloyd Samantha , Catterall Carla , Sato Chloe 
Published: February 2021

SummaryCollaborations between researchers and practitioners are vital to ensure mutual learning to inform scientific and on‐ground outcomes and government policy. Communicating outcomes from these collaborations benefit land management and restoration projects. The Ecological Society of Australia (ESA) Practitioner Engagement Working Group (PEWG) showcases and communicates applied ecological research projects, driven by partnerships between researchers and practitioners, and promotes the value of these links to on‐ground action. In December 2019, the PEWG ran the Practitioner Engagement for On‐ground Outcomes symposium at the ESA annual conference in Launceston, Tasmania, to highlight key factors that enable and limit effective collaboration in ecological projects. Overall, 17 speakers from a range of government, Indigenous and non‐government organisations delivered presentations on ecological issues. Here, we focus on six presentations that revealed eight key enablers of effective science‐practice partnerships. Of these, six related to principles underpinning translational ecology (collaboration, commitment, communication, decision‐framing context, engagement and process buy‐in). Two additional enablers were highlighted – innovation and robust science, and longevity and flexible timelines. This symposium provided a stream‐lined approach to communicate the factors which enable successful projects to a broad audience. To enhance effective researcher‐practitioner collaborations, improved practice and greater innovations in future ecosystem management projects, as well as both new and long‐term funding streams, will be required.
Love for the Neighbour as Lived Theology
Authors: Yadala Suneson Anita 
Published: February 2021

AbstractThe aim of this article is to identify the theological potential for interreligious relations as embodied in the everyday life of ordinary Christians in South India. The empirical study that underlies the discussion is based on interviews with lay churchgoers and pastors from Pentecostal and mainline Protestant churches in Bangalore. The beliefs they articulate, as well as the practices they carry out in their daily lives, are defined as their lived theology. This is analyzed through the terminological framework of theology in four voices. Interviewees express beliefs that emphasize the superiority of Christianity over other religions and the importance of evangelism. Nevertheless, in everyday life they prioritize respect for religious others and maintenance of relationships with them over sharing an exclusivist message about Christ. Their lived theology emphasizes relatedness across religious boundaries and the priority of showing love for the neighbour in practice.
Jesus and Muhammad
Authors: Rahman A. Faizur 
Published: February 2021

AbstractThis essay foregrounds the reformatory teachings of two of the greatest men that walked the earth – Jesus and Muhammad. The majority of the followers of these honoured prophets attribute their success to the power and influence of their transcultural theologies and see them as nothing more than founders of independent religions. Another presumption is that their religions are mutually exclusive. This essay looks beyond creedal orthodoxies and inflexible articles of faith to find commonalities in the approaches of prophets Jesus and Muhammad while exploring the possibility of imagining their missions as liberatory responses to the socio‐political conditions that prevailed during their times.
Radiographic technique to improve diagnosis of sagittal axial sesamoid fracture in racing Thoroughbreds with lateral condylar fracture
Authors: Labbe K. A. , Pigott J. H. 
Published: February 2021

SummaryThe current study identified 124 lateral condylar fractures of the distal metacarpus or metatarsus over a 6‐year period. Thirty of 124 lateral condylar fractures were classified as displaced. Eight of 30 displaced lateral condylar fractures and 1/86 incomplete lateral condylar fractures had concurrent sagittal axial fracture of the lateral proximal sesamoid bone. A 20‐degree DMPLO view is the most sensitive radiographic projection to identify sagittal axial fracture of the lateral proximal sesamoid bone. A flexed 20‐degree DMPLO projection demonstrates displacement of complete sagittal axial sesamoid fractures. Radiographic identification of axial sesamoid fracture is critical to provide the most accurate prognosis for return to racing. Arthroscopic assessment of the axial sesamoid fracture and cartilage injury on the lateral proximal sesamoid bone, as well as post‐operative progression, are described in four surgical cases.
Outcomes for the first wave of hospitalised patients with COVID‐19 in the South Australian context: a retrospective audit
Authors: Toh Dylan J.‐W. , Rowe Emily , Nelson Renjy , O'Connell Alice , Lim Ken , Fielke Lauren , He Jiacheng , Faunt Jeffrey 
Published: February 2021

AbstractBackgroundThe first case of corona virus disease (COVID‐19) was detected in South Australia on 1 February 2020. The Royal Adelaide Hospital (RAH) is the state's designated quarantine hospital.AimTo determine the characteristics, outcomes and predictors of outcomes for hospitalised patients with coronavirus disease (COVID‐19) within the RAH.MethodsWe performed a retrospective audit of 103 patients diagnosed with COVID‐19 who were discharged from the RAH between 14 February and 21 May 2020. We collected demographic, clinical and laboratory data through an audit of electronic medical records. The main outcome measures were: (i) the need for oxygen supplementation; (ii) need for intensive care unit (ICU) care; and (iii) death in hospital.ResultsThe median age of patients was 60 years (range 19–85). A total of 55 (53%) patients was male. All patients were independent at baseline; 37 (36%) patients suffered from hypertension. Cardiovascular disease, respiratory disease and diabetes were present in fewer than 19 (18%) patients. Obesity was present in 24 (23%) patients; 39 (38%) patients required supplemental oxygen, 18 (17%) required ICU care and 4 (4%) patients died. Older patients were significantly more at risk of oxygen requirement (median 68 vs 57.5 years, P < 0.01), ICU admission (median 66.5 vs 60 years, P = 0.04) and death (median 74.5 vs 60 years, P = 0.02). We did not find a statistically significant association between gender, body mass index and poor outcomes. Lactate dehydrogenase (LDH) was the only parameter at admission associated with oxygen requirement, ICU care and death. Peak LDH, aspartate aminotransferase, alanine aminotransferase, C‐reactive protein and neutrophil lymphocyte ratio were significantly associated with oxygen requirement, ICU admission and death (P < 0.05 for all of the above laboratory markers).ConclusionsAlthough our sample size was small, we found that certain comorbidities and laboratory values were associated with poor outcomes. This occurred in a setting where care was not influenced by limited hospital and intensive care beds.
Refugia during the last glacial period and the origin of the disjunct distribution of an insular plant
Authors: Yamada Takayuki , Kokubugata Goro , Fujii Shinji , Chen Chien‐Fan , Asakawa Akira , Ito Takuro , Maki Masayuki 
Published: February 2021

AbstractAimAlthough many phylogeographic studies have focused on continental refugia, the roles of islands as refugia have long been overlooked. In this study, we conducted phylogeographic studies of a plant with insular distribution, Microtropis japonica, to elucidate the potential roles of islands as refugia during recent glacial periods. Specifically, we test the hypothesis that two remote groups of Japanese islands (the Izu and Ryukyu Islands) were refugia for M japonica.LocationThe Izu and Ryukyu Islands of Japan and their adjacent areas including the Japanese mainland and Taiwan.TaxonMicrotropis japonica (Celastraceae).MethodsA total of 363 individuals were sampled from 44 populations of M japonica. To elucidate population genetic differentiation and demographic change in M japonica, we performed molecular variance and mismatch distribution analyses based on chloroplast DNA (cpDNA) sequence variations and Bayesian clustering and gene flow estimates based on nuclear single‐nucleotide polymorphism (SNP) data. In addition, to examine distribution changes, ecological niche modelling using the maximum entropy method was used to determine suitable habitats existing currently or during the last glacial maximum, using occurrence data and six bioclimatic variables.ResultsBoth cpDNA and nuclear SNP data showed genetic differentiation between two disjunct regions. However, cpDNA data indicated genetic differentiation within the Ryukyu Islands but not within the Izu Islands, while nuclear SNP data indicated genetic differentiation within both island groups. Ecological niche modelling showed that both the Izu and Ryukyu archipelagos had contained some islands with a climate compatible with modern M japonica climate envelopes despite climate oscillations.Main conclusionsIslands within both the Izu and Ryukyu archipelagos may have supported M japonica populations throughout historical climate oscillations. The current disjunct distribution of M japonica strongly reflects its refugial locations during the last glacial period and the subsequent range expansion. Islands were important refuges, contributing to the modern disjunct distribution of M japonica.
Rs884225 polymorphism is associated with primary hypertension by compromising interaction between epithelial growth factor receptor (EGFR) and miR‐214
Authors: Luo Fang , Wu Yitian , Ding Qunfang , Yuan Yiming , Jia Weiguo 
Published: February 2021

AbstractGenetic variations in the 3′UTR of mRNAs as well as sequences of microRNAs (miRNAs) and long non‐coding RNAs (lncRNAs) can affect gene expression by interfering with the binding between them. In this study, we investigated the role of the following polymorphisms in the risk of hypertension: the 774T > C (rs17337023) polymorphism located in the EGFR 3’ untranslated region (3’UTR), the rs884225 polymorphism located in the sequence of miR‐214, and the single nucleotide polymorphisms (SNPs) rs325797437, rs344501106, rs81286029 and rs318656749 located in the promoter of lncRNA MEG3. Taqman genotyping assays and haplotype analysis tools were used to measure the MEG3 haplotypes and the rs17337023 and rs884225 polymorphisms genotypes. The relationship between MEG3, miR‐214 and EGFR was validated using computational analysis and luciferase assays. Unlike other polymorphisms, only patients grouped according to their rs884225 genotypes exhibited varied EGFR mRNA and protein levels, which indicated that the rs884225 genotype is associated with the expression of EGFR mRNA and protein levels. MiR‐214 was confirmed to bind to MEG3 and 3’UTR of EGFR by showing that the transfection of exogenous miR‐214 significantly down‐regulated the luciferase activity of A549 and H460 cells transfected with wild‐type MEG3 or wild‐type EGFR 3’ UTR. Additionally, MEG3 overexpression inhibited miR‐214 expression while elevating the EGFR mRNA and protein expressions. Meanwhile, MEG3 down‐regulation demonstrated an opposite result, thus establishing the MEG3/miR‐214/EGRF signalling pathway. Our study confirmed that the T > C substitution of rs884225 polymorphism located in miR‐214 binding site in the 3’UTR of EGFR is associated with increased risk of primary hypertension.
Dendritic cells loaded with exosomes derived from cancer stem cell‐enriched spheroids as a potential immunotherapeutic option
Authors: Naseri Marzieh , Zöller Margot , Hadjati Jamshid , Ghods Roya , Ranaei Pirmardan Ehsan , Kiani Jafar , Eini Leila , Bozorgmehr Mahmood , Madjd Zahra 
Published: February 2021

AbstractCancer stem cells (CSCs) are responsible for therapeutic resistance and recurrence in colorectal cancer. Despite advances in immunotherapy, the inability to specifically eradicate CSCs has led to treatment failure. Hence, identification of appropriate antigen sources is a major challenge in designing dendritic cell (DC)‐based therapeutic strategies against CSCs. Here, in an in vitro model using the HT‐29 colon cancer cell line, we explored the efficacy of DCs loaded with exosomes derived from CSC‐enriched colonospheres (CSCenr‐EXOs) as an antigen source in activating CSC‐specific T‐cell responses. HT‐29 lysate, HT‐29‐EXOs and CSCenr lysate were independently assessed as separate antigen sources. Having confirmed CSCs enrichment in spheroids, CSCenr‐EXOs were purified and characterized, and their impact on DC maturation was investigated. Finally, the impact of the antigen‐pulsed DCs on the proliferation rate and also spheroid destructive capacity of autologous T cells was assessed. CSCenr‐EXOs similar to other antigen groups had no suppressive/negative impacts on phenotypic maturation of DCs as judged by the expression level of costimulatory molecules. Notably, similar to CSCenr lysate, CSCenr‐EXOs significantly increased the IL‐12/IL‐10 ratio in supernatants of mature DCs. CSCenr‐EXO‐loaded DCs effectively promoted T‐cell proliferation. Importantly, T cells stimulated with CSCenr‐EXOs disrupted spheroids' structure. Thus, CSCenr‐EXOs present a novel and promising antigen source that in combination with conventional tumour bulk‐derived antigens should be further explored in pre‐clinical immunotherapeutic settings for the efficacy in hampering recurrence and metastatic spread.
An integrative taxonomic review of theNatal mountain catfish,Amphilius natalensisBoulenger1917(Siluriformes,Amphiliidae), with description of four new species
Authors: Mazungula Daniel Nkosinathi , Chakona Albert 
Published: February 2021

AbstractAn integrative taxonomic analysis combining mitochondrial cytochrome oxidase subunit I sequences, morphology, colour pattern and two species delimitation approaches revealed the existence of five lineages within the Natal mountain catfish,Amphilius natalensis, in southern Africa. These lineages are separated by substantial genetic divergences (1.6%–9.46%), and they can be consistently distinguished from one another based on a combination of morphology and colour pattern differences. Additionally, the lineages are allopatrically distributed and confined to isolated river systems draining discrete mountain ranges, which makes gene flow among them unlikely. One of these lineages isA. natalensiss.s., which is confined to the uMngeni and Tukela river systems in KwaZulu Natal (KZN) Province in South Africa. The other four lineages represent new species to science which are described asAmphilius zuluorumsp. nov., endemic to the uMkhomazi River system in KZN,Amphilius engelbrechtisp. nov., endemic to the Inkomati River system in Mpumalanga Province in South Africa,Amphilius marshallisp. nov., endemic to the Pungwe and Lower Zambezi river systems in Zimbabwe and Mozambique, andAmphilius leopardussp. nov., endemic to the Ruo River in Malawi. The results show thatAmphilius laticaudatuswhich is endemic to the Buzi River system in Zimbabwe and Mozambique, belongs to theA. natalensiss.l. complex. A redescription ofA. laticaudatusis presented and an updated identification key for the mountain catfishes of southern Africa is provided.
Life lessons: Leaving home and financial capability of young adults
Authors: Czar Kayla , Gilbert Aaron , Scott Ayesha 
Published: February 2021

AbstractYoung adults today have access to an increasing range of financial products. However, evidence shows young adults generally have low financial capability, leading to poor financial choices with potentially severe and long‐lasting consequences. Financial experience represents one proven channel by which people develop the knowledge and ability to make better financial decisions. A potentially pivotal life experience for young adults is moving out of home, which involves a wide range of financial experiences. We examine how leaving home impacts the financial capability of New Zealanders aged 18–25. Our results suggest leaving home is associated with a significant improvement in financial capability but not an increase in financial knowledge. Providing targeted guidance to home leavers may offer an effective opportunity to improve the financial capability of young adults and minimize costly mistakes.
Characterization of short‐ and long‐term morbidity and mortality of goat kids born to does with pregnancy toxemia
Authors: Weaver Leslie F. , Boileau Melanie J. , Gilliam Lyndi L. , Taylor Jared D. 
Published: February 2021

AbstractBackgroundPregnancy toxemia is a common metabolic disease of periparturient small ruminants. Information on its effects on metabolism and perinatal adaptation of newborn lambs and kids is lacking.ObjectivesEvaluate differences in morbidity, mortality, and common biochemical and hematologic variables between pregnancy toxemia kids (PT) and control kids (CON).AnimalsSixteen kids born to does being treated at the hospital for pregnancy toxemia (blood beta‐hydroxybutyrate concentration [BHB] > 1.2 mmol/L) and 12 kids from healthy dams (dam BHB < 1.2 mmol/L) that kidded at the hospital.MethodsIn this cohort study, serial measurements of bloodL‐lactate, glucose, and BHB concentrations, arterial blood gases, hematocrit, total protein concentrations, nonesterified fatty acids (NEFAs) concentrations, and body weight were compared between groups over the first 72 hours of life. Long‐term follow‐up was performed after 3 months.ResultsPregnancy toxemia kids were more likely to require tube feeding at 0 and 12 hours (relative risk 7.7 [1.13, 52.45] and 2.8 [1.39, 5.65]). Pregnancy toxemia kids were more acidemic (7.26 ± 0.069 vs 7.34 ± 0.079,P= .003) and hyperlactatemic (8.17 ± 2.57 vs 5.48 ± 2.71,P= .003) at birth than CON kids. Control kids were 1.1 [1.01, 1.77] times more likely to survive to discharge and 2.2 [1.15, 4.20] times more likely to survive to 3 months than PT kids.Conclusions and Clinical ImportancePregnancy toxemia kids had higher short‐ and long‐term mortality and were more likely to require perinatal intervention. Weight loss in the first few days could be a useful predictor of nonsurvival.
New blood donors in times of crisis: Increased donation willingness, particularly among people at high risk for attracting SARS‐CoV‐2
Authors: Spekman Marloes L. C. , Ramondt Steven , Quee Franke A. , Prinsze Femmeke J. , Huis in 't Veld Elisabeth M. J. , van den Hurk Katja , Merz Eva‐Maria 
Published: February 2021

AbstractBackgroundTraditionally, during crises the number of new blood donors increases. However, the current coronavirus disease 2019 (COVID‐19) pandemic created additional barriers to donate due to governmental prevention measures and increased personal health risks. In this report, we examined how the pandemic affected new donor registrations in the Netherlands, especially among groups with higher risk profiles for severe COVID‐19. Additionally, we explored the role of media for blood donation and new donor registrations.Study Design and MethodsWe analyzed new donor registrations and attention for blood donation in newspapers and on social media from January until May 2020, in comparison to the same period in 2017 to 2019.ResultsAfter the introduction of nationwide prevention measures, several peaks in new donor registrations occurred, which coincided with peaks in media attention. Interestingly, people with a higher risk profile for COVID‐19 (e.g., due to age or region of residence) were overrepresented among new registrants.DiscussionIn sum, the first peak of the current pandemic has led to increased new blood donor registrations, despite the associated increased health risks. Time and future studies will have to tell whether these new donors are one‐off ‘pandemic’ donors or if they will become regular, loyal donors.
Ferumoxytol‐enhanced magnetic resonance angiography provides comparable vascular conspicuity to CT angiography in dogs with intrahepatic portosystemic shunts
Authors: Wilson Sabrina , Culp William T. N. , Wisner Erik R. , Cissell Derek D. , Finn J. Paul , Zwingenberger Allison L. 
Published: February 2021

AbstractComputed tomography angiography (CTA) is currently the gold standard imaging modality for anatomically characterizing canine hepatic vascular anomalies; with conventional, gadolinium‐enhanced MR angiography being less frequently utilized. However, both imaging modalities are limited by a brief, first pass peak of contrast medium in the vasculature that necessitates precisely timed image acquisition. A long‐acting purely intravascular magnetic resonance imaging (MRI) contrast agent, ferumoxytol, offers the potential to reduce complexity of magnetic resonance angiography (MRA) protocol planning by ensuring diagnostic contrast medium concentration in all the vessels that are targeted for imaging. Aims of this prospective, pilot, methods comparison study were to develop an optimized MRA protocol using ferumoxytol in dogs with hepatic vascular anomalies, perform a dose escalation trial to compare image quality with four‐dose regimens of ferumoxytol, and compare accuracy of vascular anatomic depiction based on the gold standard of CTA. Six dogs (10.7–36.1 kg) with portosystemic shunts (four intrahepatic left divisional shunts and two intrahepatic right divisional shunts) were recruited for inclusion in the study. A dose‐escalation trial was performed to compare image quality at four incremental dose levels of ferumoxytol (1, 2, 3, and 4 mg/kg) and to compare the accuracy of vascular anatomic detection to CTA. Ferumoxytol contrast‐enhanced MRA (CE‐MRA) at 4 mg/kg provided similar conspicuity of normal and abnormal vasculature compared to CTA with a minimal decrease in spatial resolution. Findings indicated that ferumoxytol holds promise for comprehensive, single breath hold CE‐MRA of all abdominal vessels in dogs with portosystemic shunts. Background information provided in this study can be used to support development of other future applications such as intracranial and cardiac MRA, real‐time imaging, flow quantification, and potentially sedated MRI imaging.
Geochemistry, spatial distribution, and sources of trace element pollution in the surface sediments of Port Hacking, southern Sydney, Australia
Authors: Alyazichi Yasir M. , Qasim Amin K. , Jones Brian G. , McLean Errol , Murad Jindy , Aljawi Ahmed 
Published: February 2021

Abstract
Coastal environments are subject to trace metal pollution via a combination of industry and urbanised sources. The pollutants accumulate within surface sediments, especially in the quieter backwaters of estuaries. An environmental assessment of the Port Hacking estuary, southern Sydney, Australia, was undertaken using 233 surface samples. Trace metal concentrations (Ni, Cr, Cu, Zn, Pb, and As) in these samples indicated that most elements in Port Hacking were below the relevant ANZECC/ARMCANZ guideline low trigger value (ISQG-low), but a few sites exceeded this value. The low trace metal concentrations are mainly because the catchment areas have limited urban development and few discharge points. In contrast, one site in Gunnamatta Bay has Zn and Cu concentrations that exceeded the high trigger value (ISQG-high), due to moored vessels, boatyards, and stormwater outlets in this vicinity. Port Hacking is considered to be relatively unpolluted and healthy when compared with other Sydney estuaries.