bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-Omics Approaches Reveal Unique Small RNAs Exhibited by the Uncultured Microorganisms Dwelling Deep-Sea Hydrothermal Sediment in Guaymas Basin
Authors: Nawaz Muhammad Zohaib , Wang Fengping 
Published: December 2021

Abstract
Small regulatory RNAs (sRNAs) are present in almost all investigated microbes, regarded as modulators and regulators of gene expression and also known to play their regulatory role in the environmentally significant process. It has been estimated that less than 1% of the microbes in nature are culturable in the laboratory, hindering our understanding of their physiology, and living strategies. However, recent big advancing of DNA sequencing and omics-related data analysis makes the understanding of the genetics, metabolic potentials, even ecological roles of uncultivated microbes possible. In this study, we used a metagenome and metatranscriptome based integrated approach to identifying small RNAs in the microbiome of Guaymas Basin sediments. Hundreds of environmental sRNAs comprising of 228 groups were identified based on their homology, 82% of which displayed high similarity with previously known small RNAs in Rfam database, whereas, “18%” are putative novel sRNA motifs. A putative cis-acting sRNA potentially binding to methyl coenzyme M reductase, a key enzyme in methanogenesis or anaerobic oxidation of methane (AOM), was discovered in the genome of ANaerobic MEthane oxidizing archaea group 1 (ANME-1), which were the dominate microbe in the sample. These sRNAs were actively expressed in local Guaymas Basin hydrothermal environment, suggesting important roles of sRNAs in regulating microbial activity in natural environments.
Identifying possible inaccuracy in reported birth head circumference measurements among infants in the US Zika Pregnancy and Infant Registry
Authors: Roth Nicole M. , Woodworth Kate Russell , Godfred-Cato Shana , Delaney Augustina M. , Olson Samantha M. , III John F. Nahabedian , Reynolds Megan R. , Jones Abbey M. , Neelam Varsha , Valencia-Prado Miguel , Delgado-López Camille , Lee Ellen H. , Ellis Esther M. , Lake-Burger Heather , Tonzel Julius L. , Higgins Cathleen A. , Chan Ronna L. , Tong Van T. , Gilboa Suzanne M. ,   Janet D. Cragan1, Honein Margaret A. , Moore Cynthia A. 
Published: December 2021

Abstract

The US Zika Pregnancy and Infant Registry (USZPIR) monitors infants born to mothers with confirmed or possible Zika virus (ZIKV) infection during pregnancy. The surveillance case definition for Zika-associated birth defects includes microcephaly based on head circumference (HC). We assessed birth and follow-up data from infants with birth HC measurements <3rd percentile and birthweight ≥10th percentile to determine possible misclassification of microcephaly.We developed a schema informed by literature review and expert opinion to identify possible HC measurement inaccuracy using HC growth velocity and neuroimaging results. Two or more HC measurements between 2-12 months of age were required for assessment. Inaccuracy in birth HC measurement was suspected if growth velocity was >3 centimeters/month in the first three months or HC was consistently >25th percentile during follow-up. Normal neuroimaging was considered supportive of HC measurement inaccuracy. Of 6,799 infants, 351 (5.2%) had Zika-associated birth defects, of which 111 had birth HC measurements <3rd percentile and birthweight ≥10th percentile. Of 84/111 infants with sufficient follow-up, 38/84 (45%) were classified as having possible inaccuracy of birth HC measurement, 19/84 (23%) had HC ≥3rd percentile on follow-up without meeting criteria for possible inaccuracy, and 27/84 (32%) had continued HC <3rd percentile. After excluding possible inaccuracies, the proportion of infants with Zika-associated birth defects including microcephaly decreased from 5.2% to 4.6%.About one-third of infants with Zika-associated birth defects had only microcephaly, but indications of possible measurement inaccuracy were common. Implementation of this schema in ZIKV infection during pregnancy studies can reduce misclassification of microcephaly.
The General Relativistic Perspective
Authors: Taylor David Grant 
Published: December 2021

Abstract
The Equations from General Einstein's Relativity Theory can also be framed from a Relativistically distorted perspective. General relativity slows gravitons reducing the force, so escape velocity is limited to c. Atomic structure bosons slowing makes all elements subject to decay. Energy from slowing boson structure particles would increase matter particle velocity. The lower the atomic weight, the greater the speed, so hydrogen escapes in the most significant amounts. Distortion would never be imaginary.
Characteristics and formation of corundum within syenite in the Yushishan rare metal deposits in the northeastern Tibetan Plateau
Authors: Liu Jianhua , Cao Shuyun , Zhou Dingkui , Li Xiaowen , Wu Yu , Wang Haobo , Li Wenxuan 
Published: December 2021

Abstract
Corundum is rarely found in situ within alkali syenites. A corundum-bearing syenite was found in the Yushishan rare metal deposits of the eastern section of the Altyn Tagh fault in the northeastern Tibetan Plateau, but the characteristics and formation of corundum remain unknown. We describe a corundum-bearing syenite dike emplaced in biotite plagioclase gneiss that suffered overprinted deformation with characteristics of mylonitization. The corundum crystals have variable grain sizes, and the largest ones are megacrystic with growth zoning. The corundum crystals contain a variety of mineral inclusions that are divided into primary and secondary. The primary mineral inclusions within the corundum include variable contents of Fe-Ti oxide needles, ilmenite, zircon, monazite-(Ce), potassium feldspar, pyrochlore, columbite-(Fe), magnetite, samarskite-(Y), and pyrite that indicate corundum crystallized in peraluminous Zr-rich and Si-poor alkali rock with variable TiO2 contents. Secondary mineral inclusions include Zn-rich hercynite, ilmenite, magnetite, annite, fluorapatite, and intergrowths of ilmenite with columbite-(Fe) and goethite that reveal late-stage influx of Zn-, Ti-, Fe-, and F-bearing fluids into corundum that caused metasomatism and element migration and mineral precipitation. The trace element analysis of corundum shows high-Fe and -Ga contents and low-Mg and -Cr contents that are consistent with the characteristics of corundum of magmatic origin. The trace element characteristics and the oxygen isotopes (6.2–8.2‰) results indicate that corundum crystallized in melts with the involvement of Al-rich and Si-poor crustal material.
Principles of Positivist Jurisprudence in the Teachings of Warsaw Lawyers of the First Third of the XIX Century
Authors: Kresin Oleksiy 
Published: December 2021

The article is devoted to the extremely rich and insufficiently studied heritage of Polish legal thought. The political and geographical determinants of the chosen research topic are the restoration of statehood in central Polish lands in 1807 (Duchy of Warsaw and the Kingdom of Poland) and the defeat of the November Uprising (1830-1831) followed by measures taken by the Russian authorities to limit the autonomy of the Kingdom of Poland. The intellectual milestones are the founding of the School of Law in 1807 (later the Faculty of Law of the University of Warsaw), and the closure of the University of Warsaw in 1831, as well as the significant emigration of scientists in the same year and the liquidation of the Society of Friends of Science in 1832. The intellectual milestones are also European (and first of all Central European) processes of legal thought evolution in the second half of the XVIII – first third of the XIX century, which led to the formation of the first and still insufficiently understood and studied positivism in jurisprudence, being a profound phenomenon that reveals the essence of positivism in legal thought in general.
The study found that the basic principle of jurisprudence in the vision of most Warsaw scholars during the study period was its independence from a priori and metaphysical philosophizing, and vice versa, the formation of its own philosophical and legal discourse (philosophy of positive law) based on generalization and understanding of research results. It was recognized that legal science should be a fundamentally new system of legal knowledge – positivist and social. Recognizing the historical and modern pluralism of such an organization of knowledge, Warsaw scholars have unequivocally identified themselves with the Central European jurisprudence, the core of which is the German. Warsaw scholars believed that jurisprudence was based on historical, dogmatic and philosophical approaches. Accordingly, they considered three relatively separate areas of scientific knowledge, which together can be considered as a single legal science or a system of interrelated legal sciences. Depending on the emphasis in the views of scholars on the fundamental or applied side of legal science, this system was seen differently, as well as the subject of jurisprudence – universal or more national. It can be argued that this to some extent correlated with the predominance in the views of certain scholars of the principles of historical-philosophical or historical schools.
Aharon Barak’s Concept of Human Dignity and the Notion of Dignity in Jurisprudence of Polish Constitutional Court
Authors: Szymaniec Piotr 
Published: December 2021

Israeli scholar and judge, Aharon Barak rejects the position that dignity is an axiomatic, universal concept. Moreover, he is in favor of “spacious” understanding of the right to dignity, making it a vast and broad category. The aim of the paper is to examine whether the concept of dignity presented by Barak is useful to understand the approach to human dignity as a legal concept in those Central European legal systems which have been influenced by German constitutional theory. In that regard the jurisprudence of Polish Constitutional Court is examined. The author is not fully convinced by Barak’s approach to dignity. The conclusion is drawn, however, that Barak is right when claiming that the status of an absolute right granted to the right to dignity means also that its scope is defined in a restrictive way.
Hydrochemical characteristics, hydraulic connectivity and water quality assessment of multilayer aquifers in Western Suzhou City, Northern Anhui Province, China
Authors: Ma Jie , Chen Song , Feng Songbao , Ding Diandian 
Published: December 2021

Abstract
The present study focuses on the shallow phreatic aquifer (SA) and the upper confined aquifer (CA) developed in Cenozoic loose strata, which are the major regional groundwater resources for drinking, irrigation, industry and other water-related activities. Seven samples from SA and seventeen samples from CA were analyzed to depict the hydrochemical characteristics, categorize the hydrochemical facies, evaluate the hydraulic connectivity, and appraise the drinking water and irrigation water quality. The abundance of cations is Na+ &gt; Ca2+ &gt; Mg2+ &gt; K+ and the anions is HCO3− &gt; SO42− &gt; Cl− in both aquifers, respectively. Groundwater chemistry is controlled by water-rock interactions such as halite dissolution, ion exchange, reverse ion exchange, silicate weathering, and followed by the dissolution of Glauber's salt. The low connectivity and moderate connectivity between these two aquifers has engendered. The majority of the ion concentrations are within the limit for drinking, only one sample from the shallow aquifer was greater than the limit of 250 mg/L, a total of 29% from the shallow unconfined aquifer and 14% from the confined aquifer are not within the limit of 250 mg/L. The sodium absorption ratio (SAR), residual sodium carbonate (RSC) and soluble sodium percentage (%Na) values reveal that all the samples are appropriate for irrigation uses. The the US salinity laboratory (USSL) diagram shows that sixteen CA samples and all the SA samples fall in the C3S1 zone, implying high salinity hazard and low alkalinity hazard.
Relationship Between Gender and Clinician’s Subjective Experience during the Interaction with Psychiatric Patients
Authors: Dazzi Federico , Fonzi Laura , Pallagrosi Mauro , Duro Marina , Biondi Massimo , Picardi Angelo 
Published: December 2021

Introduction:The clinician’s subjective experience can be a valuable element for diagnosis and treatment. A few factors have been recognized that affect it, such as the patient’s personality, the severity of psychopathology, and diagnosis. Other factors, such as patient’s and clinician’s gender, have not been specifically investigated. The aim of this study is to explore the impact of gender differences on the clinician’s subjective experience in a large sample of psychiatric patients.Methods:The study involved 61 psychiatrists and 960 patients attending several inpatient and outpatient psychiatric settings. The clinicians completed the Assessment of Clinician's Subjective Experience (ACSE) questionnaire after observing each patient for the first time.Results:In multivariate analysis, higher scores on the Difficulty in Attunement (p < 0.001), Engagement (p<0.05), and Impotence (p<0.01) scales were significantly associated with female clinician gender, whereas higher scores on the Tension and Disconfirmation scales were significantly associated with male clinician gender. The scores on all ACSE dimensions were also associated with the severity of psychopathology.Conclusion:The findings suggest that clinician’s gender might affect a clinician’s emotional response toward patients. Specific attention to this issue might be useful in clinical situations, not only in terms of promoting gender-balanced teams but also in terms of enhancing self-observation in clinicians evaluating patients for the first time.
Screening of Depressive Symptoms in a Russian General Population Sample: A Web-based Cross-sectional Study
Authors: Kibitov Andrey Alexandrovich , Rakitko Alexander Sergeevich , Kasyanov Evgeniy Dmitirevich , Rukavishnikov Grigoriy Viktorovich , Kozlova Kira Alexandrovna , Ilinsky Valeriy Vladimirovich , Neznanov Nikolay Grigor’evich , Mazo Galina Elevna , Kibitov Alexander Olegovich 
Published: December 2021

Background and Objective:
Web-based screening of depressive symptoms in general non-clinical population can provide better insights into actual prevalence of depressive symptoms and associated risk factors. To study the current prevalence of depressive symptoms in Russian non-clinical population we conducted screening using an online survey based on Depression subscale of Hospital Anxiety and Depression Scale (HADS-D).

Methods:
The online survey covered 2610 Russian-speaking respondents and included HADS-D, questions about sex, age and presence of cardiovascular diseases (CVD) diagnoses or symptoms in respondents.

Results:
The proportion of respondents with depressive symptoms, estimated by online HADS-D, was 14.4% (11.5% - at subclinical level, 2.9% - at clinical level). The overall HADS-D score was higher in women (p=0.003), in young individuals under 30 y.o vs. participants over 42 y.o. (p=0.004) and in individuals with self-reported CVD symptoms (p=0.00002). Linear regression analysis showed that self-reported CVD symptoms increase HADS-D score (p<0.001), but male sex (p=0.002) and older age (p<0.001) decrease it. Logistic regression showed that CVD symptoms increase the risk of depressive symptoms by HADS-D (p=0.033, OR=1.29), but older age (p=0.015, OR=0.87) and male sex (as a trend, p=0.052, OR=0.80) decrease this risk.

Conclusion:
Online survey based on HADS-D showed new patterns of depressive symptoms prevalence in Russian non-clinical population. Depressive symptoms prevalence did not differ between men and women and was higher among young people. The reported association between depressive symptoms and CVD was confirmed.
Surgical Orthodontic Treatment for Skeletal Class I with Facial Asymmetry and Occlusal Cant: A Case Report
Authors: Yamada Ryusuke , Okayama Miki , Takeda Shigehiro , Shimo Tsuyoshi , Iijima Masahiro 
Published: December 2021

Background:
Cases of facial asymmetry with chin deviation and canted occlusal plane represent a challenge in orthodontic treatment.

Case Report:
We report successful surgical orthodontic treatment for skeletal Class I with severe facial asymmetry. Miniscrew anchorage was used to decompensate the canted occlusal plane in presurgical orthodontic treatment with a fixed appliance by the intrusion of the maxillary right molars and extrusion of the left molars. Then, orthognathic surgery consisting of bilateral sagittal split osteotomy for asymmetric mandibular setback was performed. Treatment resulted in marked improvement of facial asymmetry.

Conclusion:
The use of miniscrew implant anchorage may represent a superior presurgical orthodontic treatment and expand the possibility of treatment by one-jaw surgery.
Assessing the Students’ Perception of the Quality of Dental Program offered in Saudi Arabia
Authors: Al Kuwaiti Ahmed 
Published: December 2021

Background:
In Saudi Arabia, dental students' program evaluation is highly focused on improving dental education quality, so that an effective workforce could be developed for the nation.

Objective:
This study aims to assess the students' perception of the quality of dental program offered at Saudi dental schools.

Methods:
All final year students of the selected Saudi dental schools (N=4) were included as the population of this study. The students were administered a questionnaire named “Dental Program Evaluation Survey.” The survey consisted of four dimensions, with 31 Likert scale items and one global item studying the dental students' satisfaction towards the programs offered at Saudi dental schools. The responses obtained using the survey were subjected to statistical analysis using SPSS 20.0.

Results:
The results demonstrated that the dimensions, such as faculty characteristics, institutional characteristics, the efficacy of the program, and program changes due to the COVID-19 pandemic, were perceived as “High Quality.” The cumulative percentage of most of the items was graded as “Acceptable.” Overall, 89.2% of students were satisfied with the quality of the programs offered in their dental schools. A significant difference was found in students' perception of the dimensions and overall satisfaction with respect to their gender and dental schools.

Conclusion:
Overall, the students were highly satisfied with the quality of the dental program offered in Saudi Arabia. This study would help policymakers in developing appropriate strategies that can enhance and sustain the quality of dental program offered at Saudi dental schools.
Dimensional Stability of Elastomeric Impression Material After Disinfection Via Immersion and Microwave Irradiation
Authors: R. Mohd Noorhayati , Omar Ros A. , Etajuri Enas A. 
Published: December 2021

Aims:
This study aimed to evaluate and compare the dimensional stability of two elastomeric impression materials, namely polyvinyl siloxane (PVS) and vinyl siloxanether (VSE), subjected to chemical immersion and microwave irradiation for disinfection.

Materials and Methods:
Sixty discs of PVS and VSE impression materials each were prepared using a stainless-steel test die and ring in accordance with ANSI/ADA Specification No. 19. Twenty discs of each impression material were disinfected by chemical immersion for 10 min; another 20 discs were subjected to dry microwave irradiation for 3 min. The other 20 discs served as a control group. Dimensional stability measurements were then performed using an image analyzer at 20× magnification. The data were analyzed by one-way analysis of variance (α=0.05) and Bonferroni (post hoc) test for multiple comparisons to detect significant differences between the groups.

Results:
When subjected to microwave irradiation, both PVS and VSE showed dimensional changes, but the changes were within the limit of 1.5% set by ANSI/ADA (P<0.00). VSE showed markedly better results than PVS for both disinfection methods. The immersion disinfection method resulted in a higher average percentage of linear dimensional changes than both the microwave irradiation and the control for VSE and PVS impression materials.

Conclusion:
VSE exhibited excellent dimensional stability than PVS under both chemical immersion and microwave irradiation. Microwave irradiation using conventional microwave ovens can be used in clinical settings as an alternative to other disinfection techniques because the dimensional changes of the elastomeric impression materials subjected to microwave irradiation have been observed to be within the clinically acceptable limit set by the ANSI/ADA standard.
Perception and Attitude of Dental Students and Interns Regarding the Diagnosis and Management of Oral Mucosal Lesions and Salivary Glands Hypofunction
Authors: Farag Arwa M. , Alharbi Meshal , Alamoudi Mazen , Alturki Ghassan 
Published: December 2021

Background:
The perception and attitude of dental students/graduates regarding diagnosing/managing oral medicine cases are scarcely investigated.

Objective:
The aim of this investigation was to evaluate the level of confidence in diagnosing/managing cases of oral mucosal lesions and salivary glands hypofunction.

Methods:
A 29-items questionnaire descriptive survey was distributed among dental interns and sixth-year students in the city of Jeddah during March-April of 2020.

Results:
A total of 136 (81 interns and 55 sixth-year students) completed the questionnaire, of which 69.9% were from a government school, and 30.1% were from private schools. For oral mucosal lesions [i.e., aphthous/herpes simplex virus ulceration], the majority of government and private schools’ participants reported being confident in their ability to diagnose (88.4% and 87.8%, respectively) and provide treatment (63.2% and 56.1%, respectively). For oral candidiasis, the majority were confident in their ability to diagnose (government: 95.8%; private: 59.1%) and treat (government: 77.9%; private: 65.9%). The confidence in diagnosing lesions suspicious for dysplasia/premalignancy was high in 77.9% of government and 80.5% of private schools. Similar reporting was found regarding salivary hypofunctions (government: 93.7%; private: 90.2%). For the likeness to refer, the majority of participants were likely to refer to oral medicine, as the 1st choice, followed by oral surgery.

Conclusion:
Dental interns/sixth-year students seemed to have high levels of confidence in diagnosing/managing oral mucosal lesions and salivary hypofunctions. However, the partial participation and the subjectivity of reporting may have hindered capturing the full/precise picture.
Knowledge, Attitude and Practices Regarding HIV and AIDS among High School Learners in South Africa
Authors: Fana Thanduxolo 
Published: December 2021

Background:
Globally, millions are infected with HIV/AIDS, and more than half of them are adolescents aged between 12-25 years. Inadequate knowledge, negative attitudes, and risky practices are major barriers to HIV/AIDS prevention. This study seeks to establish the knowledge, attitudes, and practices regarding HIV/AIDS among high school learners in South Africa.

Methods:
Data were collected from a randomly selected sample of 422 learners from two high schools using pre-tested questionnaires. Data were analysed using SPSS version 16.

Results:
Participants had good HIV/AIDS knowledge, attitudes, and practice levels, however, misconceptions about transmission, negative attitudes, and risky behaviour or practices were also found. Knowledge was associated with age, social status, and sources of information. Attitudes were associated with gender, age, race, social status and sources of information. Practices were associated with age, race, social class, and sources of information (p = < 0.05).

Conclusion:
Sex education (life orientation) in school and HIV/AIDS awareness programs in communities need to be intensified in order to rectify misconceptions, negative and discriminatory attitudes, unsafe and risky practices, as schools and healthcare workers were found to be the main source of HIV/AIDS information.