bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors leading to effective social participation promotion interventions for people with intellectual disability: a protocol for a systematic review
Authors: Aparicio Andrés , Arango Paulina , Espinoza Rosario , Villate Vicente , Tenorio Marcela 
Published: June 2021

Abstract
Background
People with intellectual disabilities have been historically excluded from decision-making processes. Previous literature indicates that increasing social participation may be an effective way to address this exclusion, but no systematic review of interventions designed to increase social participation of people with intellectual disabilities have been conducted. This study aims to identify and organize the factors associated with interventions that increase the social participation of people with intellectual disabilities and to provide a set of best of practices for future interventions.

Methods/design
The databases Web of Science, Scopus, LILACS, and PubMed will be searched for articles from January 2004 onwards; grey literature search will be identified through searching additional databases (such as Google Scholar and EBSCO databases). Randomized controlled trials, nonrandomized controlled trials, and controlled pre–post studies will be included. Noncontrolled pre–post studies will also be included. Observational or qualitative studies will be excluded. The primary outcomes are measures of social participation. Secondary outcomes include measures of well-being, stigma, knowledge about rights, and advocacy processes. Two reviewers will independently screen articles, extract relevant data, and assess the quality of the studies. We will provide a meta-analysis of included studies if possible, or a quantitative narrative synthesis otherwise.

Discussion
This systematic review will add to our understanding of effective social participation interventions for people with intellectual disability. It will allow us to identify and organize which factors lead to an increase in social participation and help us define a set of best practices to be followed by future interventions.

Systematic review registration
PROSPERO CRD42020189093
A semi-analytical coupled simulation approach for induction heating
Authors: Areitioaurtena Maialen , Segurajauregi Unai , Akujärvi Ville , Fisk Martin , Urresti Iker , Ukar Eneko 
Published: June 2021

AbstractThe numerical simulation of the induction heating process can be computationally expensive, especially if ferromagnetic materials are studied. There are several analytical models that describe the electromagnetic phenomena. However, these are very limited by the geometry of the coil and the workpiece. Thus, the usual method for computing more complex systems is to use the finite element method to solve the set of equations in the multiphysical system, but this easily becomes very time consuming. This paper deals with the problem of solving a coupled electromagnetic - thermal problem with higher computational efficiency. For this purpose, a semi-analytical modeling strategy is proposed, that is based on an initial finite element computation, followed by the use of analytical electromagnetic equations to solve the coupled electromagnetic-thermal problem. The usage of the simplified model is restricted to simple geometrical features such as flat or curved surfaces with great curvature to skin depth ratio. Numerical and experimental validation of the model show an average error between 0.9% and 4.1% in the prediction of the temperature evolution, reaching a greater accuracy than other analyzed commercial softwares. A 3D case of a double-row large size ball bearing is also presented, fully validating the proposed approach in terms of computational time and accuracy for complex industrial cases.
The impact of COVID-19 on adolescents with eating disorders: a cohort study
Authors: Spettigue Wendy , Obeid Nicole , Erbach Madison , Feder Stephen , Finner Natalie , Harrison Megan E. , Isserlin Leanna , Robinson Amy , Norris Mark L. 
Published: June 2021

Abstract
Background
There is a noticeable lack of evidence regarding the impact of COVID-19 and the associated lockdown on young people with eating disorders. The goals of this study were 1) to examine characteristics of adolescents presenting for eating disorder (ED) assessment since the onset of the COVID-19 pandemic; 2) to compare adolescents presenting for ED assessment since the onset of the COVID-19 pandemic to those that presented for assessment 1 year previously; 3) to examine implications of the pandemic on the system of care.

Methods
A retrospective chart review was completed on all patients assessed at a pediatric tertiary care ED program during the pandemic between April 1 and October 31, 2020, and on youth assessed during the same time frame 1 year previously. Data including body measurements and results of psychological measures was extracted from patients’ charts. Clinician reports were utilized for accounts of ED symptoms. Referrals to our program were also compared for the two time periods.

Results
Of the 48 youth assessed between April and October 2020, average age was 14.6 years and average percentage of treatment goal weight was 77.7%. 40% cited the pandemic as a trigger for their ED; of these youth, 78.9% were medically unstable compared to 55.2% of those whose ED was not triggered by the pandemic. When comparing the 2020 cohort to those assessed in 2019, youth who presented for assessment during the pandemic trended towards having lower percentage of goal weights and higher rates of self-reported impairment, and were significantly more likely to be medically unstable (p = 0.005) and to require hospitalization (p = 0.005). Higher rates of inpatient admissions, emergency room consultation requests and outpatient referrals deemed “urgent” were likewise associated with the pandemic period.

Conclusions
During the COVID-19 pandemic, youth assessed for an ED presented with high rates of medical instability and need for hospitalization. Caring for these youth may be more challenging during the pandemic, when access to services may be limited. Further research is required to better understand the impact of the pandemic on the clinical course and outcomes of EDs in adolescents.
A century of national forest inventories – informing past, present and future decisions
Authors: Breidenbach Johannes , McRoberts Ronald E. , Alberdi Iciar , Antón-Fernández Clara , Tomppo Erkki 
Published: June 2021

AbstractIn 2019, 100 years had elapsed since the first National Forest Inventory (NFI) was established in Norway. Motivated by a fear of over-exploitation of timber resources, NFIs today enable informed policy making by providing data vital to decision support at international, national, regional, and local scales. This Collection of articles celebrates the 100th anniversary of NFIs with a description of past, present, and future research aiming at improving the monitoring of forest and other terrestrial ecosystems.
Developing parametric design fashion products using 3D printing technology
Authors: Jeong Jiwoon , Park Hyein , Lee Yoojeong , Kang Jihye , Chun Jaehoon 
Published: June 2021

AbstractThis study created wearable fashion products with parametric design characteristics, using 3D printing technology. The goal of the study was to understand what parametric design features can be simulated with 3D modeling and printing technology, as well as to demonstrate what techniques can be used to produce fashion products using 3D printing technology. This study created two different parametric motifs using an FDM-type 3D printer with TPU and ABS as the printing materials. With those motifs, we produced three garments and two accessories. The limitations found during the process were modeling the exact measurement of the motifs that will merge with the apparel design seamlessly while maintaining the parametric features, as well as attaching the printed motifs to fabric without ruining the integrity of the textile. A significant implication of this study is that it recreates parametric designs on the human body and utilizes 3D printing technology for fashion products. This paper cast a light on a discussion about the technique can be applied on fashion design with full-sized body and encouraged designers to explore further with technological advancements in the future.
Barriers and facilitators affecting implementation of the Canadian clinical practice guidelines for the diagnosis of acute aortic syndrome
Authors: Dmitriew Caitlin , Ohle Robert 
Published: June 2021

Abstract
Background
Acute aortic syndrome (AAS) is an uncommon, life-threatening emergency that is frequently misdiagnosed. The 2020 Canadian clinical practice guidelines for the diagnosis of AAS incorporate all available evidence into four key recommendations. In order to facilitate the implementation of these recommendations, a clinical decision aid was created. The objective of this study was to identify barriers and facilitators among physicians prior to implementation of the guideline recommendations in a multicentre step wedge cluster randomized control trial.

Methods
We conducted semi-structured interviews with nine emergency room physicians working at five sites distributed between urban academic and rural settings. We used purposive sampling, contacting physicians until data saturation was reached. Interview questions were designed to understand potential barriers and facilitators to guideline recommendation uptake and use. Responses were analysed according to the Theoretical Domains Framework, and overarching themes describing these barriers and facilitators were identified.

Results
Two themes and six subthemes encompassing 13 theoretical domains were identified. These included clinical decision-making support, awareness of the evidence, social factors, expected consequences, ability of physicians to acquire the necessary data and ease of use. A majority of interviewees anticipated that the guideline recommendations would support clinical decision making and more effectively risk-stratify patients. Other facilitators included endorsement of the guidelines by professional organizations and peers. Barriers to implementation include the fact that laboratory testing and knowledge of the rationale for its use in the investigation of AAS were not widespread. The complexity of the clinical decision aid and concerns about test specificity were also identified as potential barriers to use.

Conclusion
Physicians were amenable to using the AAS guideline recommendations to support clinical decision-making and to reduce resource use. A structured intervention should be developed to address the identified barriers and leverage the facilitators in order to ensure successful implementation. Our findings may have implications for the implementation of other guidelines used in emergency departments.
Metacognitive knowledge and experience across multiple cognitive domains in euthymic bipolar disorder
Authors: Torres Ivan J. , Hidiroglu Ceren , Mackala Sylvia A. , Ahn Sharon , Yatham Lakshmi N. , Ozerdem Eysegul , Michalak Erin E. 
Published: June 2021

AbstractBackgroundMetacognitive knowledge (MK; general awareness of cognitive functioning) and metacognitive experience (ME; awareness of cognitive performance on a specific cognitive task) represent two facets of metacognition that are critical for daily functioning, but are understudied in bipolar disorder. This study was conducted to evaluate MK and ME across multiple cognitive domains in individuals diagnosed with bipolar disorder and unaffected volunteers, and to investigate the association between metacognition and quality of life (QoL).MethodsFifty-seven euthymic participants with bipolar disorder and 55 demographically similar unaffected volunteers provided prediction and postdiction ratings of cognitive task performance across multiple cognitive domains. Self-ratings were compared to objective task performance, and indices of MK and ME accuracy were generated and compared between groups. Participants rated QoL on the Quality of Life in Bipolar Disorder Scale (QoL.BD).ResultsMetacognitive inaccuracies in both MK and ME were observed in participants with bipolar disorder, but only in select cognitive domains. Furthermore, most metacognitive inaccuracies involved underestimation of cognitive ability. Metacognitive indices were minimally associated with medication variables and mood symptoms, but several indices were related to QoL.ConclusionsIndividuals with bipolar disorder demonstrate inaccuracies in rating their cognitive functioning and in rating their online cognitive task performance, but only on select cognitive functions. The tendency to underestimate performance may reflect a negative information processing bias characteristic of mood disorders. Metacognitive variables were also predictive of QoL, indicating that further understanding of cognitive self-appraisals in persons with bipolar disorder has significant clinical relevance.
Implementation of Electronic Patient-Reported Outcomes for Symptom Monitoring in a Large Multisite Community Oncology Practice: Dancing the Texas Two-Step Through a Pandemic
Authors: Patt Debra , Wilfong Lalan , Hudson Kathryn Elizabeth , Patel Amila , Books Holly , Pearson Ben , Boren Rhonda , Patil Shrutika , Olson-Celli Kristin , Basch Ethan 
Published: June 2021

PURPOSE Among patients receiving chemotherapy, symptom monitoring with electronic patient-reported outcomes (ePROs) is associated with improved clinical outcomes, satisfaction, and compliance with therapy. Standard approaches for ePRO implementation are not established, warranting evaluation in community cancer practices. We present implementation findings of ePRO symptom monitoring across a large multisite community oncology practice network. METHODS Patients initiating a new systemic therapy at one of the 210 practice sites at Texas Oncology were invited to use the Navigating Cancer ePRO platform, with stepped-wedge implementation from July to December 2020. Participating patients received a weekly prompt by text message or e-mail to self-report common symptoms and well-being. Severe self-reported symptoms triggered a real-time notification to nursing triage to address the symptom. Enrollment and compliance were systematically tracked weekly with evaluation of barriers and facilitators to adoption and sustainability. RESULTS Four thousand three hundred seventy-five patients planning systemic treatment were enrolled and participated. Seventy-three percent (1,841 of 2,522) of enrolled patients completed at least one ePRO assessment. Among these individuals, 64% (16,299 of 25,061) of available weekly ePRO assessments were completed. Over a 10-week period, compliance declined from 72% to 52%. Barriers currently being addressed include lack of a second reminder text or e-mail prompt, inconsistent discussion of reported ePROs by clinicians at visits, and COVID-related changes in workflow. Facilitators included ease of use and patient and staff engagement on the importance of PROs for symptom management. CONCLUSION ePROs can be effectively implemented in community oncology practice. Utilization of ePROs is high but diminishes over time without attention to barriers. Ongoing work to address barriers and optimize compliance are underway.
Association of a Remote Patient Monitoring (RPM) Program With Reduced Hospitalizations in Cancer Patients With COVID-19
Authors: Pritchett Joshua C. , Borah Bijan J. , Desai Aakash P. , Xie Zhuoer , Saliba Antoine N. , Leventakos Konstantinos , Coffey Jordan D. , Pearson Kristina K. , Speicher Leigh L. , Orenstein Robert , Virk Abinash , Ganesh Ravindra , Paludo Jonas , Halfdanarson Thorvardur R. , Haddad Tufia C. 
Published: June 2021

PURPOSE: The goal of this study was to assess the impact of an interdisciplinary remote patient monitoring (RPM) program on clinical outcomes and acute care utilization in cancer patients with COVID-19. METHODS: This is a cross-sectional analysis following a prospective observational study performed at Mayo Clinic Cancer Center. Adult patients receiving cancer-directed therapy or in recent remission on active surveillance with polymerase chain reaction–confirmed SARS-CoV-2 infection between March 18 and July 31, 2020, were included. RPM was composed of in-home technology to assess symptoms and physiologic data with centralized nursing and physician oversight. RESULTS: During the study timeframe, 224 patients with cancer were diagnosed with COVID-19. Of the 187 patients (83%) initially managed in the outpatient setting, those who did not receive RPM were significantly more likely to experience hospitalization than those receiving RPM. Following balancing of patient characteristics by inverse propensity score weighting, rates of hospitalization for RPM and non-RPM patients were 2.8% and 13%, respectively, implying that the use of RPM was associated with a 78% relative risk reduction in hospital admission rate (95% CI, 54 to 102; P = .002). Furthermore, when hospitalized, these patients experienced a shorter length of stay and fewer prolonged hospitalizations, intensive care unit admissions, and deaths, although these trends did not reach statistical significance. CONCLUSION: The use of RPM and a centralized virtual care team was associated with a reduction in hospital admission rate and lower overall acute care resource utilization among cancer patients with COVID-19.
Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development
Authors: Schoultz Elin , Johansson Ellen , Moccia Carmen , Jakubikova Iva , Ravi Naveen , Liang Shawn , Carlsson Therese , Montelius Mikael , Patyra Konrad , Kero Jukka , Paulsson Kajsa , Fagman Henrik , Bergo Martin O. , Nilsson Mikael 
Published: June 2021

ABSTRACT
Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV600E) from the thyroglobulin promoter (TgCreERT2). Spontaneous activation of this Braf-mutant allele due to leaky activity of the Cre recombinase revealed that intrinsic properties of thyroid follicles determined BRAF-mutant cell fate. Papillary thyroid carcinomas developed multicentrically within a normal microenvironment. Each tumor originated from a single follicle that provided a confined space for growth of a distinct tumor phenotype. Lineage tracing revealed oligoclonal tumor development in infancy and early selection of BRAFV600E kinase inhibitor-resistant clones. Somatic mutations were few, non-recurrent and limited to advanced tumors. Female mice developed larger tumors than males, reproducing the gender difference of human thyroid cancer. These data indicate that BRAFV600E-induced tumorigenesis is spatiotemporally regulated depending on the maturity and heterogeneity of follicles. Moreover, thyroid tissue organization seems to determine whether a BRAF-mutant lineage becomes a cancerized lineage. The TgCreERT2;BrafCA/+ sporadic thyroid cancer mouse model provides a new tool to evaluate drug therapy at different stages of tumor evolution.
This article has an associated First Person interview with the first author of the paper.
Composite Materials by Building Block Chemistry Using Weak Interaction
Authors: Akashi Mitsuru , Akagi Takami 
Published: June 2021

Abstract
Layer-by-Layer (LbL) assembly of interactive polymers onto surfaces leads to the construction of multilayered ultrathin films, which can be done simply by alternately dipping the substrate into various solutions. The range of applications of this LbL assembly can be broadened by introducing molecular recognition mechanisms for polymers and proteins, and by using weak interactions such as van der Waals interactions and biological recognition. As a specific example, it can be applied to the formation of stereocomplexes of poly(methyl methacrylate) (PMMA), poly-lactide (PLA), and fibronectin-collagen as extracellular matrix proteins. In weakly interacting LbL assemblies, the polymer chain tends to be placed in the most structurally stable state. This feature has been successfully used for template polymerization of stereoregular polymers, significant morphological control of biodegradable nanomaterials, and fabrication of three-dimensional (3D) cellular tissue constructs. LbL assembly based on weak interactions is expected to further stimulate interest in the interdisciplinary fields of bioscience and polymer chemistry. Using LbL technology to create functional 3D tissues, such as skin models (LbL-3D Skin) and heart models (LbL-3D Heart), will be a breakthrough in science and technology.
Characterization of CTX-M-15-Klebsiella pneumoniae from inpatients and outpatients of a teaching hospital
Authors: Muzaheed Muzaheed , Sattar Shaikh Naveed , Sattar Shaikh Saeed , Acharya Sadananda , Sarwar Moosa Shajiya , Habeeb Shaikh Mohammad , M. Alzahrani Faisal , Ibrahim Alomar Amer 
Published: June 2021

Background The presence of Extended-spectrum β-lactamase (ESBL) positive bacteria in hospital setting is an aggravating influential factor for hospitalized patients, and its consequences may be hazardous. Therefore, there is a need for rapid detection methods for newly emerging drug-resistant bacteria. This study was aimed at the molecular characterization of ESBL-positive Klebsiella pneumoniae isolates recovered from clinical samples. Methods A total of 513 K. pneumoniae isolates were obtained from various clinical samples during June 2019 to May 2020. The collected isolates were investigated for antimicrobial susceptibility (antibiogram), and PCR and DNA sequencing were performed to analyse the ESBL genes. Results Among the 513 isolates, as many as 359 (69.9%) were ESBL producers and 87.5% were multi-drug resistant, while none had resistance to imipenem. PCR scored 3% blaTEM, 3% blaSHV, and 60% blaCTX-M-15 genes for the tested isolates. Conclusion The study showed that CTX-M-15 was the major prevalent ESBL type among the isolates. Additionally, all the isolates were susceptible to carbapenems. Screening and detection of ESBL tests are necessary among all isolates from the enterobacteriaceae family in routine microbiology laboratory to prevent associated nosocomial infections. A larger study is essential to understand molecular epidemiology of ESBL producing organisms to minimize morbidities due to these multidrug resistant organisms.