bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotection of Kolaviron by Regulation of Nuclear Factor Erythroid 2-related Factor 2 in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice Model of Parkinson Disease
Authors: Awogbindin Ifeoluwa , Onasanwo Samuel , Ezekiel Oluwatoyin , Akindoyeni Inioluwa , Mustapha Yusuf , Farombi Olatunde 
Published: November 2021

Objectives:
Parkinson’s disease (PD) is the most prevalent movement disorder. Available therapies are palliative with no effect on disease progression. We have previously demonstrated that kolaviron (KV), a natural anti-inflammatory and antioxidant agent, suppressed behavioral defect, redo-inflammation, and nigrostriatal pathology in rotenone PD model. The present study investigates the neuroprotective effect of KV focusing on DJ-1/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.

Material and Methods:
All-trans retinoic acid (ATRA, 10 mg/kg/day) was used to inhibit Nrf2. PD was established with four doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg) at 2 h interval. MPTP mice were pre-treated with either KV (200 mg/kg/day), ATRA or both for 7 days before MPTP. Mice were evaluated for locomotor defects and indices of oxidative stress, neuroinflammation and neurotransmission as well as pathological tyrosine hydroxylase expression PD were evaluated in the striatum.

Results:
ATRA alone in mice did not exhibit neurobehavioral defect but caused striatal toxicity, mild nigrostriatal pathology, significant nitrosative stress, and Nrf2 cascade inhibition. KV+ATRA mice were slow in movement with frequent short-lived interruptions and oxidative striatal pathology. ATRA aggravated MPTP-associated locomotor incompetence and could not prevent nigrostriatal toxicity with evident vacuolated striosome and pyknotic/degenerating dopaminergic neurons. MPTP induced acute locomotor, exploratory, and motor incompetence, which was prevented by KV treatment. In addition, KV treatment restored MPTP-mediated depletion of endogenous antioxidant, striatal nitrosative stress, and oxidative damage with elevated DJ-1 level, potentiated Nrf2/NAD(P)H; quinone oxidoreductase-1 cytoprotective capacity, reduced Kelch-like ECH-associated protein 1 expression, and limited striatal pathology. However, ATRA treatment attenuated all the protective effects of KV on MPTP-challenged mice. Meanwhile, other ATRA-combinations elicited significant DJ-1 and Nrf2 induction but are associated striatal toxicity/pathology.

Conclusion:
This suggests that KV may be conferring protection through a yet-undetermined DJ-1 downstream cytoprotective effect dependent on the KV-mediated attenuation of oxidative environment.
Surgical treatment of ruptured right middle cerebral artery mycotic aneurysm and central nervous system aspergillosis: Clinical case and literature review
Authors: Konovalov Anton , Sharipov Oleg , Shekhtman Oleg , Gadzhiagaev Vadim , Kalinin Pavel 
Published: November 2021

Background:
Central nervous system (CNS) aspergillosis is more often met in patients with expressed immune suppression. Still, in 50% of cases of meningitis caused by Aspergillus spp., it is observed in patients without expressed immune suppression. The prognosis of CNS aspergillosis is unfavorable with the general rate of lethality around 70%.

Case Description:
Clinical case of a 58-year-old man who developed an Aspergillus abscess in the chiasmosellar region and an associated mycotic aneurysm of the right middle cerebral artery (MCA) and intracerebral hemorrhage. Microsurgical clipping of the fusiform-ectatic aneurysm of the right MCA in the conditions of rupture was performed. An extra-intracranial micro anastomosis was formed on the right. An open biopsy of the neoplasm in the chiasmosellar region was made. The neoplasm was yellow and destroyed the bone plate of the skull base. Biopsy results: Mycotic lesion (aspergillosis). The analysis of surgical treatment for mycotic aneurysms in the acute period of hemorrhage in patients with aspergillosis revealed a high rate of lethality. The issue of the feasibility and effectiveness of complicated revascularization interventions in the patients with hemorrhage and aspergillosis remains unsolved.

Conclusion:
The lack of generally accepted tactics of the treatment of this pathology requires further studies and systemic analysis. A high risk of the lethal outcome in patients with invasive mycotic infection and rupture of mycotic aneurysm highlight the importance of timely diagnostics and the beginning of antimycotic therapy. WThe issue of the evaluation of the revascularization methods effectiveness in patients after surgical treatment of a mycotic aneurysm associated with cerebral aspergillosis remains poor.
DEVELOPMENT OF A TWIN-SCREW PRESS FOR OBTAINING OIL FROM SUNFLOWER SEEDS BY COLD PRESSING
Authors: ГУКАСЯН А.В. , БОРОДЯНСКИЙ В.П. , СМЫЧАГИН Е.О. 
Published: November 2021

Большинство маслозаводов, расположенных на территории Южного федерального округа, для получения растительных масел используют технологию прессования. Для сохранения максимального количества полезных нутриентов сырья при производстве подсолнечного масла применяют холодный отжим (без дополнительного нагрева). С целью разработки двухшнекового пресса для получения из семян подсолнечника масла методом холодного отжима проведен расчет основных технических характеристик конструкции: производительность 375 кг/ч; выход масла 42%; температура на входе/выходе – не менее 15/(115–125)°C; напряжение питания 380 В; номинальная мощность электрообогрева 12 кВт; влажность перерабатываемой культуры 7–9%; номинальная мощность привода 18,5 кВт; габариты, мм: длина 2750, ширина 1200, высота (без бункера) 1100; масса 1000 кг. С учетом технических характеристик разработана 3D-модель двухшнекового маслопресса. С использованием программы Deal Компо проведена оценка эффективности разработанной модели двухшнекового маслопресса по трем критериям: установленная мощность, габариты, масса. Установлено, что разработанный двухшнековый маслопресс по исследованным параметрам имел лучший результат (34,84%) среди исследованных аналогичных моделей маслопрессов.
Most of the oil factories, located on the territory of the Southern federal district, for production of vegetable oil using extrusion technology. To preserve the maximum amount of useful nutrients of raw materials in the production of sunflower oil cold pressing is used (without additional heating). In order to develop a twin-screw oil press for cold-pressed sunflower seed oil, the main technical characteristics of the design were calculated: capacity 375 kg/h; oil yield 42%; inlet/outlet temperature – at least 15/(115–125)°C; supply voltage 380 V; rated electric heating power 12 kW; humidity of the processed crop 7–9%; rated drive power 18,5 kW; dimensions, mm: length 2750, width 1200, height (without hopper) 1100; weight 1000 kg. Taking into account the technical characteristics, a 3D-model of a twin-screw oil press has been developed. Using the Deal Compo program the effectiveness of the developed model of a twin-screw oil press was evaluated according to three criteria: installed capacity, dimensions, weight. It was found that the developed twin-screw oil press had the best result (34,84%) among the studied similar models of oil presses according to the studied parameters.
INVESTIGATION OF THE CHEMICAL COMPOSITION OF PEA GRAIN PROCESSING PRODUCTS FOR THE ENRICHMENT OF FLOUR PASTRY PRODUCTS
Authors: БОЛГОВА Д.Ю. , ТАРАСЕНКО Н.А. , ЧУМАК И.А. 
Published: November 2021

Одним из многочисленных способов обогащения мучных кондитерских изделий является введение в их рецептуру натуральных ингредиентов растительного происхождения. Особый интерес для кондитерской отрасли представляет зерно гороха, богатое белком. Исследован химический состав продуктов переработки зерна гороха – концентрата горохового белка и крахмальной фракции зерна гороха. Оценена возможность их использования для обогащения мучных кондитерских изделий. Установлено, что концентрат горохового белка содержит 53–55% протеина, незаменимые аминокислоты, поэтому обладает высокой биологической ценностью. Перевариваемость аминокислот горохового белка составляет 94%. Крахмальная фракция зерна гороха содержит 62–70% крахмала. Продукты переработки зерна гороха имеют низкий гликемический индекс. Использование продуктов переработки зерна гороха позволит повысить пищевую и биологическую ценность мучных кондитерских изделий за счет увеличения содержания белка, незаменимых аминокислот, минеральных веществ и резистентного к перевариванию крахмала.
One of the many ways to enrich flour confectionery products is the introduction of natural ingredients of plant origin into their formulation. Of particular interest for the pastry industry is pea grain, rich in protein. The chemical composition of pea grain processing products – pea protein concentrate and the starch fraction of pea grain has been studied. The possibility of their use for enriching flour pastry products is estimated. It was found that the pea protein concentrate contains 53–55% protein, essential amino acids, so it has a high biological value. The digestibility of amino acids of pea protein is 94%. The starch fraction of pea grain contains 62–70% starch. Pea grain processing products have a low glycemic index. The use of peagrain processing products will increase the nutritional and biological value of flour pastry products by increasing the content of protein, essential amino acids, minerals and starch resistant to digestion.
Financial management and product marketing training for the Program Keluarga Harapan Groups
Authors: Puspita Wulan Dri , Rahayu Dewi Ayu 
Published: November 2021

The managing of Hope Family Program or Program Keluarga Harapan (PKH) is the supervisor of the business unit in the form of electronic warung gotong royong (e-Warong) which is a social assistance program to synergies between PKH and the Joint Venture Group or Kelompok Usaha Bersama (KUBE). PKH of Bantur’s subdistrict experienced several problems related to financial management for their business activities, especially their inventory recording and they were not aware to promote through marketplaces. Therefore by the program of community service the University of Merdeka Malang, PKH Bantur’s subdistrict was expected to be able to gain an understanding of inventory recording and marketing to solve their problems by using google forms, google spreadsheet, and Shopee. There are three methods for these activities: lectures, practices, and discussions. These activities are divided into two sessions. The first session was introducing the importance of financial management, inventory management, and the use of google form and google spreadsheet. The second session explained digital marketing and the use of Shopee. The participants looked enthusiastic during the event. Through these activities, participants can understand the importance of managing inventory, the benefits of google form and google spreadsheets to control their inventory, also they can use Shopee as marketing media to gain more income.
Desalinizador solar de múltiples etapas para su aplicación en zonas costeras del Ecuador
Authors: Urresta Esteban , Moya Cajas Marcelo , Campana Andres , Rodríguez Dario 
Published: November 2021

Se ha desarrollado un desalinizador solar con recuperación de calor para su aplicación en zonas costeras del Ecuador con escasez de agua dulce. El aparato consta de una torre de destilación de 3 etapas conectada a un colector solar plano. La energía solar absorbida por el colector es transferida mediante circulación natural a la torre de destilación, donde en cada etapa se recupera el calor de condensación del agua para incrementar el destilado producido. El diseño modular del equipo permite variar la producción de agua, desde unos pocos litros hasta más de un metro cúbico al día. El prototipo tiene pocas partes móviles y puede ser armado y desarmado rápidamente, lo que facilita su operación y mantenimiento. La producción mensual promedio del desalinizador varía entre 4.3 y 5.8 kg/día (2.44 y 3.29 kg/m2). El desempeño del desalinizador fue analizado con un modelo matemático, cuya exactitud fue mejorada al evaluar experimentalmente los coeficientes de transferencia de calor por convección presentes en la torre de destilación. Se realizó una simulación en Matlab-Simulink que permite predecir las temperaturas, destilado generado y flujos de calor en la unidad. La simulación de un día completo de operación del destilador tuvo resultados muy satisfactorios, con una diferencia de únicamente el 7.7 % entre los datos teóricos y experimentales. La simulación también fue utilizada para analizar mejoras en el desempeño del equipo, determinándose que la producción del desalinizador podría incrementarse hasta en un 107 %.
STUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN
Authors: Al-Qaisi Bushra Ibrahim 
Published: November 2021

The present investigation aimed to study the Adenosine Deaminase activity in induction Cytogentic and histopathological change in skin and eyes of sumicidine treated rats. The study Included. 1-Adenosine deaminase activity . 2-Total serum protein. 3-Micronuclei in binucleated cell. 4-Histopathological changes in skin and eyes.
19 white male rats were used . They are randomly allocated into 3 groups : 1st group was fed 2% sumicidine for 15 days. 2nd group was fed 2% heating sumicidine for 15 days . 3rd group was kept on normal diet. Blood Adenosine Deaminase activity and Total serum protein in 1 and 2 group significantly decreased at 15 and 30 days of treated. The results
indicated that sumicidine increased significantly micronucleus in group 1 and 2. Multifocal granulomatous lesions in skin & eyes of group 1 and 2 were found characterized by highly aggregation of cells (Lymphocytes, Macrophages, Foreign body giant cells and fibroblasts).
In conclusion , Sumicidine even heated accompaying in decreased in decreased Adenosine Deaminase activity and total serum protein , in part a possible factor in the cytogenetic effect and accompanying granuloma formation in skin and eye .
A STUDY ON THE BACTERIAL DISSEMINATION AND EXPERIMENTAL PATHOLOGY OF SALMONELLA PARATYPHI - B INFECTION IN WHITE MICE
Authors: Al-Joboury Khalil H. 
Published: November 2021

An attempt to simulate paratyphoid fever-B, in the experimental animals has been carried out in white mice. Paratyphoid bacilli type-B was isolated from the febrile patients in the Ibn-Al-Khatib hospital. One LD50 was enough to produce disease in the white mice, however 10 doses were used for mice. The microorganism was inoculated intraperitoneally in to the experimental animals; the course of the dissemination within the animals was clarified by sacrificing two mice at specific intervals after inoculation and for 30 days. The organs of the sacrificed and dead mice were examined for the presence ofmicroorganisms. The microorganism were found in the spleen, liver and mediastinal lymph node for 29,25 and 17 days postinfection respectively, whereas, the microorganisms were persist in the lungs and heart blood for 11 days and in the brain and kidneys for 7 days postinoculation. The pathological changes were initiated as a neutrophils aggregates and microabscesses in the spleen, liver and mediastinal lymph node. During the second week post infection, these microabscesses and neutrophils aggregates will be replaced by mononuclear cells (lymphocytes and macrophages) to form granulomatous type lesion in these organs and to become more chronic and fibrosed, during third and fourth week post-infection. Also mild miscellaneous pathological lesions were demonstrated during the first week in brain kidney and in the lungs and gradually disappeared.
HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
Authors: Balash Khawla Jassim 
Published: November 2021

Permethrin, is a synthetic insecticide of appreciably low mammalian toxicity, it is especially useful for household purposes. This work aimed to study the gonadotoxic effect of this insecticide in Swiss mice, using two oral doses of 2000 and 3000 mg/kg b. w. for 30 days. The daily dose was 1.66 mg/kg and 2.5 mg/kg of active ingredient of permethrin for group | and group || respectively. The effect was determined by counting the percentage of damaged seminiferous tubules, their average diameter, and the spermatogenesis rate, also the changes in body weight and in testes-to-body weight ratio. Results showed that the insecticide caused significant reduction in body weight, increase in testes weight, as well as testes-to-body weight ratio, seminiferous tubules in treated animals were found to increase in diameter showing low degrees of damage. Nevertheless, spermatogenic activity was almost normal but in descending order, and Leydig cells remained unaffected. It was concluded that permethrin, has a slight gonadotoxic effect at the doses used which may not really affect the fertility of animals at the doses used.
Penentuan Penerima Bantuan Rumah Tidak Layak Huni Menggunakan Metode Simple Additive Weghting
Authors: Pertiwi Sonia Ratnaning , Utami Yustina Retno Wahyu , Harjanto Sri 
Published: November 2021

Uninhabitable Housing Assistance (RTLH) is a government program which distribute to village office, it has purpose to improve the life quality of community. Poor people can life convenient with Uninhibitable Houses Assistence. Determination of social assistence construction of Uninhabitable Houses is going to do by relying on the intitution. The purpose of this research is creating a decision support system that can help to determine the appropriate poor people are receiving social assistence of Uninhabitable House (RTLH) using simple additive weighting (SAW) method. It is used the creteria such as, the monthly income, the occupation, the total of burden, the condition of house wall, the condition of house floor, the condition of house roof, and the condition of bathroom. The result of this research is the beneficial system for receiver of Uninhabitable Houses.
SISTEM INFORMASI MONITORING ANTRIAN DAN REKOMENDASI DOKTER KANDUNGAN BERBASIS MOBILE
Authors: Ramadhan Fadli Fairuz , Sari Yunita Sartika 
Published: November 2021

<span lang="IN">Kesehatan ibu hamil tidak lepas dari peran dokter kandungan. Dokter kandungan bertugas melakukan pemeriksaan dan monitoring perkembangan janin didalam kandungan sekaligus kesehatan ibu hamil. Untuk mendapatkan pelayanan maksimal, dibutuhkan dokter kandungan yang terbaik. Pemilihan dokter kandungan pada saat ini dilakukan dengan cara survei dokter kandungan yang ada di sekitar tempat tinggal atau dengan mengumpulkan informasi dari orang lain, baik dengan cara menanyakan langsung kepada orang tersebut atau lewat forum yang ada di internet. Waktu tunggu pelayanan yang tidak produktif juga merupakan masalah bagi ibu hamil dalam memeriksa ke dokter kandungan karena memakan waktu yang lama. Informasi antrian yang sulit didapat dan tidak akurat membuat ibu hamil dan pendamping harus benar-benar memonitor antrian padahal waktu menunggu tersebut dapat dimanfaatkan untuk kegiatan lain yang lebih bermanfaat. Untuk itu, penelitian ini akan membangun sebuah system informasi monitoring antrian dan rating dokter kandungan berbasis mobile untuk memudahkan ibu hamil dalam memeriksa ke dokter kandungan. Pada penelitian ini, rating tertinggi yang diberikan oleh pasien nantinya sebagai penilaian rekomendasi dokter kandungan. Hasil dari penelitian ini adalah berupa system informasi monitoring antrian dan rating dokter kandungan berdasarkan nilai preferensi terbesar</span>
FEATURES OF THE CUMULATIVE INCIDENCE OF LYMPHOMAS IN DIFFERENT REGIONS OF THE CHERKASY REGION
Authors: Paramonov V.V. , Dyagil I.S. 
Published: November 2021

The aim is to compare the cumulative incidence of Hodgkin's lymphoma and non-Hodgkin's lymphomas between conditionally clean and polluted regions of the Cherkasy region in 2001, 2014.
Materials and methods. The incidence of Hodgkin's lymphoma and non-Hodgkin's lymphomas in conditionally clean, radioactive, chemical and radioactively and chemically contaminated regions of the Cherkasy region per 100 thousand population according to the All-Ukrainian census conducted in 2001 and published by the State Statistical Service of Ukraine in 2014.
Results. According to the results of our study, in 2001, in the chemically contaminated region of the Cherkasy region, there was an increase in the incidence of mainly diffuse large B-cell lymphoma by 3.781 (p = 0.043) times compared to its conditionally clean territory (1.076; 0.022-2.130 versus 4.070; 0.082-8.058 per 100 thousand population, respectively). In the chemically contaminated area in 2014, a 3.314 times (p = 0.035) higher level of cumulative incidence of unspecified lymphomas was also revealed (1.793; 0.358-3.228 versus 5.945; 0.734-11.156 per 100 thousand population, respectively) compared to clean areas of the Cherkasy region.
Conclusions. Thus, the results of our study showed that in 2001, living in a chemically contaminated area increased the growth of the cumulative incidence of diffuse B-cell lymphoma, and in 2014 - lymphomas of an unspecified type.
SYSTEM AND SYNERGETIC METHODOLOGY TO RESEARCH DOCTOR'S PROFESSIONAL COMPETENCES IN THE MULTIPROFILE HEALTHCARE INSTITUTIONS
Authors: Shevtsov A.H. 
Published: November 2021

The national strategy for a new health care system formation in Ukraine requires medical institutions to comply with national and international standards of medical service quality and staff training, based on the concepts of their professional competencies, provided by undergraduate education and postgraduate training of doctors, nurses and managers.
The goals of radical reform of this system call for the need of additional studying and updating of methodological approaches to the formation of health care workers' competencies on the basis of modern post-non-classical scientific picture of the world.
The aim of the research. To determine the system and synergetic methodology and the program directions for research of professional competencies of the employees in the multiprofile health care institutions in the frame of the modern post-non-classical synergetic discourse.
Material and methods.
Theoretical research was conducted in the frame of the post-non-classical scientific paradigm with the use of system and synergetic analysis. Program areas of the research were determined on the project-conceptual modelling and forecasting of applied research work within the activities of a multipfofile health care institution.
Results.
In the determination and implementation of program areas of research of the list of professional competencies specific to a multipfofile health care institutions employees with a purpose of providing integrated medical care, it is expedient to adhere to system and synergetic modelling. It is necessary to identify the main classification features and descriptors of professional competencies of the medical institutions employees, in particular on the basis of ontological approach and method of group expert evaluation, understanding the studied set of professional competencies as a system of interconnected and interdependent competencies which is an open, nonlinear, dissipative and with a certain level of complexity and self-organization system.
Conclusions.
To scientifically substantiate the multidisciplinary system of formation and development of the professional competencies of the multiprofile medical institution workers, it is necessary to create a reliable model of this system based on modern theoretical and methodological principles in the post-non-classical scientific paradigm, i.e. on system and synergetic approach via use of both general and special methods of cognition.