bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of an integrated e-Telecom system for improving telecom systems on ships
Authors: Jungwoo Kim , Son Jooyoung 
Published: September 2021

Abstract
The advancement of communication technologies including satellites has been conducive to the ever-evolving ship management. The increasing needs for the accident prevention and the optimized shipping lead to a wide range of methods of ship management using the telecom systems onboard ships. Future ships including smart-ships will be equipped with telecom systems capable of dealing with the ship management and operation in collaboration with land stations. Yet, currently, the development and application of telecom systems onboard ships are nearly at standstill due to the maritime regulations set out decades ago which limit the technological development and translate new technologies as costly investments. Unlike the technological advancement of land-based telecom systems, the existing telecom systems onboard ships have not been integrated until now but installed and operated separately on board ships. Beyond new and/or reinforced features, future ships should consider both scalable and operational aspects. In the future, telecom systems onboard ships will manage all ship-related data and play pivotal roles in controlling ships anywhere in the world. In that respect, it is crucial to integrate the discrete communication systems for stability and efficiency of telecom systems onboard ships. The integration of telecom systems onboard ships will facilitate the availability of futuristic technologies such as unmanned vessels and maritime autonomous surface ships (MASS). This paper proposes a method of designing an e-telecom system integrating the existing telecom systems onboard ships. Despite the proposed e-telecom system’s slower performance in latency resulting from additional devices, the results of the present experiment prove that there is no significant difference in its latency in data processing in comparison to the  existing telecom system.
Setting Up Geriatric Care in Subsaharan Africa : A 1-Year Experience in the Yaounde Central Hospital of Cameroon
Authors: Essomba Marie Josiane Ntsama , Nzana Victorine Bandolo , Njonnou Raoul Sylvain Simeni , Choukem Simeon Pierre , Ciaffi Laura , Paula Ginette , Zingui-Ottou Marylin , Sobngwi Eugène , Tabue-Teguo Maturin 
Published: September 2021

Abstract
Background: As the share of the older population is growing worldwide, health systems in developing countries need a policy shift to address the challenge of the optimization of healthcare across age groups. Many older people in resource-limited countries will seek specific care due to multimorbidity and frailty, as the burden of non-communicable diseases is getting heavier. Methods: Over a one-year period, we trained healthcare workers and developed new procedures of care in the geriatric unit of the Yaoundé Central Hospital in Cameroon, using the Acute Care for Elders (ACE) model. This model of care in Geriatrics is based on a patient-centered approach and is focused on preventing functional decline in acutely ill older patients. Results: During the implementation of the ACE model, 202 patients were hospitalized in the unit, of whom 60.9% (n=123) were female; the mean (SD) age was 79.3 (8.8) years. A multidisciplinary team was brought together, including a geriatrician, two general practitioners, two geriatric nurses, two advanced practice nurses and a social worker. After a thorough examination of the care procedures, nurses were given complementary missions, such as assessing functional status and providing therapeutic education to the patients and their family members. All hospitalized and ambulatory patients were offered a comprehensive geriatric assessment at the outpatient clinic.Conclusion: It was possible to establish a comprehensive model of care for older patients in our hospital with few trained personnel. Further actions are needed to improve the care of older people in resource-limited settings.
Identification of All-to-All Protein-Protein Interactions Based on Deep Hash Learning
Authors: Jiang Yue , Shen Lin , Lin Jie 
Published: September 2021

Abstract
Background: Protein-protein interaction (PPI) is vital for life processes, diseases treatment and new drugs discovery. The computational prediction of PPI is well accepted for its inexpensive and efficient nature comparing to the wet-lab experiment. When a new protein comes, one try to find whether there is any PPI relationship between this new protein and existing proteins, the current computational prediction methods usually compare this new protein to existing proteins one by one in pairwise. This is time comsuming. Results: We proposed an more efficient model, Deep Hash Learning Protein-and-Protein Interaction (DHL-PPI) model, to predict all-to-all PPI relationship on a database. First, DHL-PPI encodes a protein sequence into a binary Hash code based on the features extracted from sequences by using deep learning technique. This encoding scheme enables the PPI discrimination problem to be a much simpler searching problem. A protein with a binary code can be regarded as a number. In the prescreen of PPI prediction stage, the string match problem of searching a string against a database with M proteins can be turned into a much more simpler problem: to find a number inside an sorted array with length M. This prescreen process narrows down proteins inside the whole database into a much smaller candidate set for further confirmation. At last, DHL-PPI uses the Hamming distance to determine the final PPI relationship. Conclusions: The experimental results confirmed that DHL-PPI is feasible and effective. Using a dataset with strictly negative PPI examples of four species, DHL-PPI is superior or competitive to the other state-of-the-art methods in terms of precision, recall or F1 score. Furthermore, in the prediction stage, the proposed DHL-PPI decrease the usual time compexity of O(M2 ) to O(MlogM) for predicting all-to-all PPI interactons between any pairs in M proteins on a database. A protein database can be stored in the proposed encoding scheme and waited to be searched, which is a potential novel encoding scheme to cope with current searching problem for a large volume of database.
Machine learning model of the catalytic efficiency and specificity of acyl-ACP thioesterase variants generated by natural and in vitro directed evolution
Authors: Jing Fuyuan , Chen Keting , Yandeau-Nelson Marna , Nikolau Basil 
Published: September 2021

Abstract
Modulating the catalytic activity of acyl-ACP thioesterase (TE) is an important biotechnological target for effectively increasing flux and diversifying products of the fatty acid biosynthesis pathway. In this study, a directed evolution approach was developed to improve the fatty acid productivity and fatty acid diversity of E. coli strains expressing variant acyl-ACP TEs. A single round of directed in vitro evolution, coupled with a high-throughput colorimetric screen, identified 26 novel acyl-ACP TE variants, which convey up to 10-fold increase in fatty acid productivity, and altered fatty acid profiles when expressed in a bacterial host strain. These in vitro generated variant acyl-ACP TEs, in combination with 31 natural variants isolated from diverse phylogenetic origins were analyzed with a random forest classifier machine learning tool, generating a quantitative model that identified 22 amino acid residues, which define important structural features that determine the substrate specificity of acyl-ACP TE.
Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study
Authors: Iqbal Jamshaid , Khadadah Najat , Mohammed Ahmad 
Published: September 2021

Abstract
Background: Toxoplasmosis is caused by an obligate intracellular opportunistic protozoan parasite, Toxoplasma gondii, with a worldwide distribution. T. gondii infection among pregnant women during the first trimester may transmit infection to the fetus with serious congenital consequences. No data is available on knowledge, attitude and preventive behavior towards toxoplasmosis among pregnant women in Kuwait. This cross-sectional study evaluated knowledge, attitude, and preventive behavior towards toxoplasmosis among women in Kuwait, and reviewed the situation in the Middle east.Methods: Data related to socioeconomic status, knowledge and attitude towards toxoplasmosis were collected from 326 adult female school/university students, and 86 pregnant women through a self-administered online questionnaire during 2019-2021. Participants were divided into two main groups: women with pregnancy experience (PEG) and never-pregnant group (NPG).Results: PEG (n=212) included 114 currently pregnant and 98 women with history of an earlier pregnancy. NPG included 200 subjects. All participants belonged to a medium-to-high social status and minimum high school education. Nearly 50% of PEG women had inadequate knowledge towards toxoplasma infection, and only 33 (15.6%) knew its mode of transmission compared to 35 (17.5%) in the NPG (P=0.597). A significantly higher number of women in PEG (97 of 212, 45.8%) knew it can be prevented compared to 66 of 200 (33%) in NPG (P= 0.008). Only 35 (16.5%) of PEG women knew about screening tests for toxoplasma infection, and their main source of information on toxoplasmosis was healthcare professionals and family/friends compared with NPG women who got information through newspapers/books. PEG Women exhibited enhanced preventive behavior towards toxoplasmosis. Nearly 50% of all PEG participants lacked basic knowledge towards toxoplasmosis but >90% of them avoided most high-risk activities during their pregnancy. In addition, this is the first study in the Middle east conducted through an online survey to collect relevant information related to toxoplasmosis from pregnant women. Conclusions: This study highlights inadequate knowledge and preventive behavior towards toxoplasmosis among Kuwaiti women. Thus, health education on toxoplasmosis should be offered to all adult/pregnant women to reduce congenital toxoplasmosis.
Ge/Si Multilayer Epitaxy and Removal of Dislocations from Ge-nanosheet-channel MOSFETs
Authors: Chu Chun-Lin , Chang Jen-Yi , Chen Po-Yen , Wang Po-Yu , Hsu Shu-Han , Chou Dean 
Published: September 2021

Abstract
Horizontally stacked pure-Ge-nanosheet gate-all-around field-effect transistors (GAA FETs) were developed in this study. Large lattice mismatch Ge/Si multilayers were intentionally grown as the starting material rather than Ge/GeSi multilayers to acquire the benefits of the considerable difference in material properties of Ge and Si for realising selective etching. Flat Ge/Si multilayers were grown at a low temperature to preclude island growth. The shape of Ge nanosheets was almost retained after etching owing to the excellent selectivity. Additionally, dislocations were observed in suspended Ge nanosheets because of the absence of a Ge/Si interface and the disappearance of the dislocation-line tension force owing to the elongation of misfit dislocation at the interface. Forming gas annealing of the suspended Ge nanosheets resulted in a significant increase in the glide force compared to the dislocation-line tension force; the dislocations were easily removed because of this condition and the small size of the nanosheets. Based on this structure, a new mechanism of dislocation removal from suspended Ge nanosheet structures by annealing was described, which resulted in the structures exhibiting excellent gate control and electrical properties.
Aquifer Unit Management Plan (AUMP) For Groundwater Resources Management of Multi-layered Coastal Aquifer System
Authors: Gnanasundar Devadasan , Senthilkumar Mohanavelu 
Published: September 2021

Abstract
To address the vulnerability of coastal aquifer to over exploitation and sea water intrusion, a groundwater resources management plan titled as Aquifer Unit Management Plan (AUMP) is designed to provide valuable guidance for groundwater management of a multi-layered cuddalore coastal aquifer system located east coast of South India. The aquifer unit management plan is based on the summative examination of the aquifer unit disposition, response of hydraulic heads to recharge and discharge and effect of increased pumping on aquifer hydraulics. The safe hydraulic heads and annual exploitable potential were considered as the guiding factors to manage fresh groundwater resources of the coastal aquifer. The results show that the process of sea water intrusion has already started and with the present rate of pumping (1034.86 mcmy-1), the sea water intrusion risk has increased manifold all along the coast. The salient management strategies recommended are; restricting pumping to 695 mcmy-1, stepping up recharge activities in recharge zone, adopting water use efficiency methods and regulation in the coastal zone. AUMP is simple and can guide water managers to plan for sustainable groundwater withdrawal and safe guard the coastal aquifer from sea water intrusion and ensure sustainability of groundwater abstraction structures.
Preparation of Natural Silk Protein-Based Flame Retardant
Authors: Sun Zhihao , Li Zheng , Ma Zhongfei , Zheng Minxue , Zhan Wang 
Published: September 2021

Abstract
To counter paper flammability, SF-JR400/MP-SiO2 sourced from natural silk protein may be applied to the paper surface using layer-by-layer assembly (LbL). The microstructure and composition of the coating may be assessed using SEM, FTIR and XPS. Presence of the coating increases the paper combustion limiting oxygen index (LOI) from 20.4% to 38%. Compared to untreated DBP, TGA analysis shows that the initial decomposition temperature of DBP rises from 115˚C to 148˚C. Residual char yield increases from 11.3% to 38.8%. The formation of a surface char layer protects paper internal fibers from heat feedback and consequent thermal decomposition. Analysis using CONE indicates that a 25-layer assembly can reduce the peak and total heat dissipation by 88.4% and 54.7%, respectively analysis suggests that silk may function as an agent to accelerate the coating, formation of a protective.
Numerical Evaluation of a 70-m Deep Hydro-Power Station Foundation Pit Dewatering
Authors: Wang Jianxiu , Deng Yansheng , Wang Xiaobo , Liu Xiaotian , Zhou Nianqing 
Published: September 2021

Abstract
The average depth of Yamansu hydropower station foundation pit is 70 m. The foundation pit was excavated with five-level slopes. The lowering of groundwater level is significant for excavation. Drainage and pumping were adopted in dewatering. Pumping tests were performed to reverse hydraulic parameters and calibrate numerical models. Numerical simulations were performed to evaluate the dewatering scheme. In the first stage, powerhouse tailrace canal was excavated and utilized as a drainage channel to lower the groundwater level. The drawdown and hydraulic gradient were evaluated to prevent potential water inrush, erosion, piping, and slope failure. In the second stage, cutoff wall and pumping wells were evaluated to lower the groundwater level. The influences of depth, permeability, and thickness of the cutoff wall were evaluated. Dewatering scheme was revised accordingly based on the evaluation. The optimized dewatering scheme, which can be referred by similar engineering, was performed and verified successfully.
Impact of SOD2, PNPLA3, ABCC1, CBR1 And ABCG2 Variants Upon Toxicities of Induction Therapy In Childhood Acute Lymphoblastic Leukemia
Authors: Aslam Sara , Ameer Sonia , NA Shabana , Ahmed Mehboob 
Published: September 2021

Abstract
Chemotherapy related toxicities have been the major factor limiting the success of acute lymphoblastic leukemia (ALL) induction therapy. Several factors, including the pharmacogenetics of asparagenase and anthracyclines, could contribute to difference in treatment outcome in ALL. We investigated the significance of variations in genes that are involved in hepatic toxicity and cardiotoxicity in acute lymphoblastic leukemia (ALL). Genotyping of SOD2 (rs4880), PNPL3 (rs738409) and ABCC1 (rs4148350), CBR1 (rs9024) and ABCG2 (rs2231142) was performed by Tetra-ARMS PCR-based technique to evaluate the genotype-phenotype correlation. Our results showed only the minor allele G of SOD2 rs4880 increase the risk of hepatic toxicity [OR=2.63 (1.42-4.84), P=<.05] while minor alleles of other SNPs showed protective impact. However, the genetic contrast analysis showed a recessive form of SOD2 rs4880 [OR=7.82 (3.86-15.85), P=<0.05] and PNPLA3 I148M [OR=5.82 (3.43-9.87), P=<0.05] variants whereas dominant genotype of ABCC1 rs4148350 [OR=2.52 (1.55-4.10), P=<0.05] significantly predisposes hepatotoxicity. Furthermore, heterozygous form of ABCG2 rs2231142 [OR=5.25 (1.84-14.95), P=<0.05] and recessive genotype of 3′UTR variant CBR1 rs9024 [OR=2.31 (1.31-4.07), P=<0.05] were strongly associated with cardiotoxicity. The information obtained from these genetic variations could offer biomarkers for individualization of therapeutic intervention in ALL.
Pure Red Cell Aplasia Secondary to Rheumatoid Arthritis
Authors: Weerasinghe Suneth , Karunathilake Parackrama , Ralapanawa Udaya , Jayalath Thilak , Abeygunawardena Shamali , Rathnayaka Manel 
Published: September 2021

Abstract
BackgroundRheumatoid arthritis (RA) is a common autoimmune disease with many extra-articular manifestations. Pure red cell aplasia (PRCA) is a rare manifestation of RA and is sparsely documented in the literature with a variable clinical outcome following immunosuppressive therapy. Case presentationA 63-year-old female presented with transfusion-dependent anaemia associated with deforming inflammatory arthritis, who also had leukopenia, right subclavian venous thrombosis, and generalized lymphadenopathy. The diagnosis of RA following initial clinical workup and additional blood and bone marrow investigations revealed PRCA as a secondary manifestation of RA after excluding other secondary causes, such as infections, thymoma, thrombophilic conditions and haematological malignancy. She responded well to oral prednisolone, cyclosporine A and hydroxychloroquine, where she attained complete recovery in two months. ConclusionPRCA is a disabling illness that may lead to transfusion-dependent anaemia, which may occur due to rare extrapulmonary manifestation of RA. The diagnosis of PRCA secondary to RA may be challenging where haematological investigations, including bone marrow biopsy, will aid in the diagnosis, and early diagnosis and treatment will bring about a better outcome.
Validation of a Computerized Decision Support System To Review Pharmacotherapy Treatment: Scheduling Guidelines
Authors: Zapelini Clávison Martinelli , Galato Dayani , Alano Graziela Modolon , Martins Karina Saviatto Carvalho , Trauthman Silvana Cristina , Soares Alessandra Sá , Trevisol Fabiana Schuelter , Trevisol Daisson José 
Published: September 2021

Abstract
Background

In the pharmacotherapy review process, the pharmacist needs to list various information about the patient and the set of medications he will use, information that is never available at the point of care.
Methods

The aim of the study was to validate an intelligent information system, which was developed to assist the scheduling activity in the pharmacotherapy review process. The system used the concept of Genetic Algorithms. To validate it, appointments of hypothetical cases (ten) were made by the system and by human specialists. These schedules were qualitatively evaluated by pharmaceutical specialists with clinical and research experience in the pharmacotherapy review process. The degree of agreement between the assessments of the appointments carried out by the pharmaceutical specialists and by the system were measured using the Kappa index with a 95% confidence interval.
Results

In detecting errors, propositions, the system was able to identify 80% of errors, with human specialists identifying between 20% and 70% of errors. In relation to the general evaluation, the system obtained 87,3% of the compared evaluations, with the human specialist who came closest to this index obtained 75,5%.
Conclusion

It can be concluded that with the methodology used, the investigation met the objectives and confirmed the initial hypothesis. There are indications that the system can help in the Pharmacotherapy review process, being able to find prescription errors as well as to establish times for the use of medications according to the patient’s routine.
Efficacy and Safety of Bone-Targeting Radioisotopes in Patients with Bone Metastases: A Meta-Analysis
Authors: Ye Wanzhong , Fan Yijun , Shen Guoping 
Published: September 2021

Abstract
Background: Radionuclides such as Strontium-89, Samarium-153, and Radium-223 are commonly used for the treatment of bone metastases (BM) and they have shown efficacy in previous studies. The aim of this meta-analysis is to compare the curative performance of different types of radionuclides in patients with BM, and to provide evidence for further future research and clinical practice.Methods: The electronic databases of PubMed, Web of Science, Embase, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure (CNKI) were searched. Studies using radionuclides therapy to cure patients were included. Pooled overall response rate, occurrence rates of common adverse events, hazard ratio (HR), and their respective 95% confidence interval (CIs) were calculated.Results: A total of 28 articles with 33 studies patients were identified for inclusion in this meta-analysis. The types of radionuclides used in the studies contained 89Sr, 153Sm, 223Ra, 186Re, and 188Re. The overall response rate was 72% [66%, 77%]. The respective overall response rates of 89Sr, 153Sm, and 223Ra were 72% [64%, 79%], 80% [75%, 84%], and 54% [32%, 75%]. In the survival analysis, the pooled HR was 0.85 [0.67, 1.08]. The pooled occurrence rate of leucocyte hematological toxicity of any grade was 5% [2%, 8%]. The pooled occurrence rate of thrombocytopenia of any grade was 7% [5%, 8%]. With regard to anemia, the pooled occurrence rate of any grade was 15% [11%, 19%].Conclusion: The results of this meta-analysis indicate that radionuclides therapy is efficacious in patients, type of radionuclides and history of patients should be considered to prevent potential adverse events.
Maternal Antimüllerian Hormone as a Predictor of Euploid Is Independently Associated With Cumulative Live Birth Rates
Authors: Wu Xiaoling , Zhang Huixia , Niu Wenbin , Xu Jiawei , Jin Haixia , Li Gang 
Published: September 2021

Abstract
Background: Serum antimÜllerian hormone (AMH) level has been reported to be associated with pregnancy rates after assisted reproduction. It is unclear whether AMH levels affect number of euploid blastocysts and cumulative live birth rates (CLBR). The aim of this study was to investigate whether AMH levels are associated with cumulative live birth rates (CLBR) through their relationship with oocyte quality.Methods: A total of 975 consecutive infertile women undergoing 1825 preimplantation genetic screening (PGS) analysis. Serum AMH levels were measured by AMH Gen II assay kit within the 3 months before Controlled Ovarian Hyperstimulation. Embryos were cultured and biopsied at the blastocyst stage. Results: Among 975 women undergoing PGS analysis. Age, serum AMH and number of oocytes retrieved were significantly and independently related to number of euploid blastocysts available for patients to transfer (P < .001). in patients displaying superior serum AMH levels, cumulative live birth rates (CLBR) were significantly increased independently from age and number of oocytes retrieved (P < .001), and this group with lower AMH levels also showed increased pregnancy loss rates.Conclusions: Serum AMH levels are positively age-independent associated with cumulative live birth rates after all viable embryos are transferred from the first ovarian stimulation cycle. And embryonic euploidy outcome was superior in patients with higher AMH levels. These present findings confirm that serum AMH levels might reflect not only ovarian reserve but also qualitative aspects of oocytes, which will effect the clinical application of PGS.