bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Manifestations in Diabetes Mellitus- A Review
Authors: Kumari Subham , Gnanasundaram N. 
Published: December 2021

This article deals with the characteristic of clinical findings of diabetes mellitus (DM) in the mouth and teeth. Identification of these findings in the examination of the mouth will help to diagnose DM. Symptoms such as dryness of the mouth (xerostomia), burning sensation, painful gingival swelling, and mobility of teeth due to uncontrolled DM are explained. Signs such as gingivitis, periodontitis, multiple periodontal abscesses, and fungal lesions such as Candidiasis are explained. Oral symptoms and signs may enable medical and dental specialists to diagnose diabetes. Proper diagnosis will ensure proper treatment. “Diabetes is a good disease with bad companions” quoted Dr. Sam G. P. Mosses, a renowned diabetologist in India. It is true. Diabetes is a biochemical disorder where there is a failure of peripheral utilization of sugar in cells due to insulin deficiency or defectiveness causing accumulation of excess sugar in the tissues, thus leading to hyperglycemia, glycosuria, polyuria, polyphagia, and polydipsia. It is difficult to find out when exactly the disease develops with a hyperglycemic state and how to identify the disease in the early stages. Diabetes is a reversible disease and can be controlled by restoring sugar metabolism by correcting insulin deficiency or defectiveness. Thus, the complications are considered as the bad companions of this disease. DM is a disease with systemic involvement affecting various structures and organs. The mouth is also affected by DM. If a medical or dental specialist is fully familiarized with Oral changes in DM, they can diagnose the undiagnosed diabetes through the examination of the mouth. Further confirmation of diagnosis can be made by a biochemical study of blood and urine.
This article elaborates and explains the various mouth changes in diabetics for diagnosis and management.
Stem Cells Application in Oral Mucosal Disorders
Authors: Rajbhoj Ashwini Nerkar , Khare Vikram V. , Aditya Amita , Pande Suhas , Happy Daisy , Anasane Nayana 
Published: December 2021

Background:
Regenerative medicine, tissue engineering, and surgery coupled with advances in materials science form an alliance of emerging interdisciplinary fields that combines the principles of cellular and molecular biology and biomedical engineering to support intrinsic healing and replace or regenerate cells, tissues, or organs, with the restoration of impaired function. The present-day treatment modalities for oral mucosal lesions are not satisfactory. Various studies have shown the successful role of stem cell therapy in the treatment of precancerous conditions, oral ulcers, wounds, and mucositis. The awareness among and knowledge of oral medicine and radiology (OMR) specialists regarding the therapeutic application of stem cells for the treatment of oral mucosal disorders is a relatively unexplored arena.

Aim and Objectives:
The present study was conducted to assess the awareness among and knowledge of OMR specialists regarding the application of stem cells for the treatment of oral mucosal disorders and compare the results based on age, area of work, and years of experience of the participants.

Materials and Methods:
The present study included a rapid, short, cross-sectional online survey. It was conducted using a web-based survey platform called Google Forms. A total of 203 OMR specialists were selected by simple random method for participating in the study. A self-administered, 10-point questionnaire in the form of an online survey was used to assess the awareness and knowledge of OMR specialists. A Chi-square test was used for statistical analysis.

Results and Conclusions:
Overall, awareness and knowledge were found to be more in the participants below 29 years of age, doing specialty practice, and with an experience of fewer than 5 years. A significant association of age, and area of work with awareness and knowledge was observed.
Effect on Mental Health of Health-care Providers during COVID-19 Pandemic
Authors: Sharma Arvind , Dubey Priyanka , Soni Deepali , Sharma Richa , Bharti Aditi , Singh Tej Pratap 
Published: December 2021

Background:
Health-care providers played a crucial role in responding to the public health emergency due to COVID-19 pandemic. Therefore, our study aimed to assess depression, anxiety, and stress (DAS) levels among the health-care providers in a COVID-19 dedicated health-care facility.

Methodology:
From the month of August to December 2020, a cross-sectional study was conducted on health-care providers who were involved in providing health-care services to COVID-19 patients in a tertiary care institute of Jabalpur by purposive convenient sampling through online Google Forms. The study tool used was validated depression, anxiety, and stress scale-21 having a good internal consistency having Cronbach's alpha value 0.85.

Results:
From 112 health-care providers, higher level of anxiety was found (29.46%) followed by depression (17.85%) and stress (16.07%). Mild, moderate, severe, and extremely severe anxiety were found in 18.75%, 7.14%, 1.78%, and 1.78%, respectively. Mild and moderate depression were found in 9.82% and 8.03%. Mild, moderate, and severe stress were found in 8.92%, 6.25%, and 0.89% of health-care providers, respectively. A significant association of depression, stress, and anxiety with designation of the participants was found (P < 0.001).

Conclusion:
To combat DAS, it is necessary to cascade awareness and knowledge should be disseminated. Regular screening of health-care providers, counseling, and stress management programs should be conducted.
Use of Intermittent Preventive Therapy and Incidence of Acute Malaria in Pregnancy among Postpartum Women at University College Hospital, Ibadan, Nigeria
Authors: Ifebude Joshua Ebuka , Idowu Caleb Oluwasegun , Awolude Olutosin A. 
Published: December 2021

Background:
Malaria in pregnancy remains a significant cause of feto-maternal morbidity and mortality especially in regions of high prevalence like Nigeria. Intermittent preventive therapy (IPT) for malaria is an important measure to abate this menace.

Aim:
The aim is to determine the uptake and effectiveness of IPT in relation to the occurrence of malaria, despite the use of IPT in pregnancy.

Patients, Materials and Methods:
This was a cross-sectional study conducted in UCH, Ibadan from October 1, to December 31, 2020. A total of 150 postpartum women were selected using the total sampling technique of all consenting participants. Structured questionnaires were used for data collection.

Results:
About 87.7% of the respondents took IPT in the index pregnancy. Of these, 15.4%, 50.8%, and 33.8% of participants took one, two, and three doses, respectively. The factors that determined intermittent preventive treatment for malaria in pregnancy (IPTp) uptake include occupation (P = 0.001), booking status (P = 0.002), antenatal care attendance (P = 0.001), and level of IPTp awareness (P = 0.002). About 48.0% of respondents indicated that they were treated for malaria in the index pregnancy. Meanwhile, only about 15.3% of those who took IPT were treated for malaria in pregnancy. It was found that the use of IPT (P = 0.03) and an increasing number of IPT doses used (P = 0.03) were associated with a reduction in the prevalence of malaria in pregnancy.

Conclusion:
The uptake of the current recommendation for IPT-SP that stipulates the use of monthly doses of IPT till delivery with a target of a minimum of three doses was quite poor. There is therefore an urgent need for widespread awareness and implementation of the World Health Organization and national guidelines on prevention of malaria. The prevalence of malaria declined with the number of doses of IPT-SP used by the respondents. This emphasizes the need for adequate dosing of IPT.
Trudinger’s inequalities for Riesz potentials in Morrey spaces of double phase functionals on half spaces
Authors: Mizuta Yoshihiro , Shimomura Tetsu 
Published: December 2021

AbstractOur aim in this paper is to establish Trudinger’s exponential integrability for Riesz potentials in weighted Morrey spaces on the half space. As an application, we obtain Trudinger’s inequality for Riesz potentials in the framework of double phase functionals.
La langue entre écrit et oral
Authors: Hnilicová Karolina 
Published: December 2021

La communication dans toutes les langues peut prendre soit la forme orale, soit la forme écrite. Ces formes peuvent partager certaines caractéristiques ou, au contraire, elles peuvent se différer complètement. Quelques particularités sont liées aussi au français écrit et oral, comme c’est d’ailleurs montré dans la première partie de cet article. Son objectif est, cependant, d’étudier plus aux détails ces particularités sur un genre médiatique spécifique. Ainsi, connaissant des phénomènes traditionnellement associés à la communication orale et écrite en français, cet article cherche et montre leur présence dans une émission radiophonique Pop & Co, qui appartient au genre de la « chronique de radio ». Même si ce genre paraît bien connu par des auditeurs francophones, les chroniques semblent toujours mal décrites en ce qui concerne leur structure et l’emploi du langage. Parmi les caractéristiques communes à plusieurs genres radiophoniques, celle qui ressort pour les chroniques est leur préparation sous forme textuelle suivie de la lecture à haute voix à la radio. La combinaison du français écrit et oral ainsi que la recherche linguistique médiocre dans ce domaine nous ont amenés à l’investigation plus détaillée de ce genre. L’analyse que nous proposons se focalise sur l’observation non seulement de la structure de l’émission mais aussi de la présence des constructions linguistiques traditionnellement liées au français écrit ou oral. Ainsi, cette analyse se donne pour objectif de situer la « chronique » sur le continuum linguistique écrit/oral, et de dire en quoi on peut y voir une combinaison équilibrée des deux.
Quelques remarques sur la vie et l'œuvre de Jean Vodaine, pour honorer le centenaire de sa naissance
Authors: Ferlež Urh 
Published: December 2021

L’article est écrit pour honorer le centenaire de la naissance du poète, typographe, peintre, imprimeur et éditeur Jean Vodaine. Il est né à Čiginj, en Slovénie, le 6 juillet 1921, dans une famille ouvrière qui déménagé en Lorraine en 1924. Au début de sa carrière, Jean Vodaine travaille comme ouvrier parallèlement à ses activités artistiques. Après un grave accident, il se consacre entièrement à l’art. Il est le fondateur de Dire, revue littéraire régionale mais de portée internationale, autour de laquelle il réunit des poètes du monde entier. Il l’a lui-même mise en page et imprimée sur sa propre presse. Il a mis l’accent sur la conception typographique des textes, ce qui fait de ses revues des Gesamkunstwerks. L’importance de son travail réside dans le fait qu’il ait réussi à apporter la culture dans une région culturellement moins développée profitant de sa position « carrefour » où se sont rencontrées les influences et les artistes allemands, français, belges, luxembourgeois et immigrés. Il avait des liens avec le cercle des artistes de l’art brut dont plusieurs membres, comme Vodaine, appartenaient à la classe ouvrière. Pour les Slovènes, il est important en tant que promoteur de la poésie slovène en France. Sa double identité nationale et linguistique aussi bien que la qualité de ses œuvres le rendent intéressant du point de vue biographique ainsi que du point de vue esthétique encore au 21ème siècle, bien qu’il soit relativement inconnu dans son pays natal. Jean Vodaine est décédé le 8 août 2006.
Rationalization and ‘Religization’ in the Modern Theory of International Relations.
Authors: Reinhardt R. 
Published: December 2021

Р.О. Райнхардт – доцент кафедры дипломатии МГИМО МИД России, специалист в области истории и теории дипломатии. Его основные научные интересы охватывают такие темы, как экономическая дипломатия, научная дипломатия, международное научнотехническое сотрудничество в контексте российской внешней политики, а также внешних связей ЕС. Окончил МГИМО МИД России. В 2016 г. получил ученую степень кандидата экономических наук.Беседу вел С.М. Маркедонов, главный редактор журнала «Международная аналитика»
Association between clinical characteristics and pain relief in patients with axial spondyloarthritis treated with non-steroidal anti-inflammatory drugs
Authors: Deng Shiyi , He Yi , Deng Sisi , Sun Erwei , Li Li 
Published: December 2021

Objectives: The aim of this study was to evaluate pain relief in axial spondyloarthritis (axSpA) patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) and to investigate the relation of the demographic, clinical, and psychological characteristics with pain relief.
Patients and methods: Between February 2017 and December 2019, a total of 94 patients (61 males, 33 females; mean age: 28.3±8.1 years; range, 14 to 54 years) who were diagnosed with axSpA and treated with NSAIDs were included. The patients were assessed at baseline and at three months. A reduction of 30% in the Numeric Rating Scale (NRS) indicates a clinically meaningful improvement. The patients were divided into the relief group (≥30% improvement in NRS) and non-relief group (<30% improvement). Potential influential factors for pain relief such as neuropathic pain (NP), disease activity, function, pain catastrophizing, and pain self-efficacy were assessed. The relationship between patients’ characteristics and pain relief was analyzed.
Results: Seventy-two (76.6%) patients achieved pain relief. These patients had significantly higher baseline erythrocyte sedimentation rate, C-reactive protein, and lower percentage of NP. There was no significant difference between the two groups in function, pain catastrophizing, and pain self-efficacy. Multiple logistic regression analysis revealed that patients with NP were less likely to achieve pain relief (odds ratio [OR]: 3.531, 95% confidence interval [CI]: 1.155-10.789; p=0.027).
Conclusion: Pain relief is still insufficient in some axSpA patients, despite the administration of NSAIDs. The presence of NP is significantly associated with poor pain relief. Alternative medications instead of NSAIDs are needed to achieve optimal pain relief, when NP is diagnosed.
Validity and reliability of the Mini-Osteoarthritis Knee and Hip Quality of Life scale in Turkish population
Authors: Tuncay Duruöz Mehmet , Acer Kasman Sevtap , Hande Gezer Halise , Duruöz Evrim 
Published: December 2021

Objectives: This study aims to investigate the validity and reliability of the Turkish version of the Mini-Osteoarthritis Knee and Hip Quality of Life (Mini-OAKHQoL) scale developed to assess the quality of life (QoL) in patients with knee and/or hip osteoarthritis.
Patients and methods: Between May 2018 and May 2020, a total of 83 patients (11 males, 72 females; mean age: 58.1±10.0 years; range, 39 to 81 years) with knee and/or hip osteoarthritis were included. Demographic, clinical, and survey data (Mini-OAKHQoL, Nottingham Health Profile, Short Form-36, Western Ontario and McMaster Universities Osteoarthritis Index, Lequesne Index, and Visual Analog Scale of pain intensity) were recorded. Missing data, floor effect, and ceiling effect were calculated. For reliability analysis, internal consistency and test-retest reliability were discovered. Face, content, convergent, and divergent validities were applied.
Results: Among the patients, 52 (62.65%) had knee osteoarthritis, 26 (31.32%) had hip osteoarthritis, and five (6.02%) had both. Mini-OAKHQoL had a good face and content validity. The average item completion rate was 96.9%, with the time needed to perform was about 4 min. None of the subscales of Mini-OAKHQoL presented floor or ceiling effect, with a good range of responses. The Cronbach alpha coefficients and intraclass correlation coefficient (ICC) analysis of the subscales ranged from 0.927 to 0.676 and 0.987 to 0.843, respectively. Regarding convergent validity, the physical activities, mental health, and pain subscales of Mini-OAKHQoL had moderate to high correlations with the topic-related subset of the other QoL surveys. There were no or weak correlations between Mini-OAKHQoL and non-QoL parameters, indicating its divergent validity.
Conclusion: The Turkish version of Mini-OAKHQoL is a valid, reliable, simple, practical, accurate, completable, comprehensive, and disease-specific self-report instrument to assess QoL in patients with knee and/or hip osteoarthritis.
Measuring the impact of an educational intervention in rheumatoid arthritis: An open-label, randomized trial
Authors: Michou Laëtitia , Julien Anne-Sophie , Witteman Holly O. , Légaré Jean , Ratelle Lucie , Godbout Alexandra , Tardif Johanne , Côté Suzanne , Boily Geneviève , Lui Rebecca , Ikic Alena , Trudeau Judith , Tremblay Jean-Luc , Fortin Isabelle , Bessette Louis , Chetaille Anne-Laure , Fortin Paul R 
Published: December 2021

Objectives: This study aims to determine whether patients with active rheumatoid arthritis (RA), either starting on or changing biological or targeted synthetic disease-modifying antirheumatic drugs (DMARDs), demonstrate better self-management safety skills three months after receiving a multidisciplinary educational intervention compared to patients receiving usual care.
Patients and methods: Between October 2015 and October 2018 , this open-label, randomized-controlled trial included a total of 107 RA patients (27 males, 80 females; mean age: 60.2±10.4 years; range, 54 to 71 years) who were on treatment or in whom treatment was changed with a biological or targeted synthetic DMARD. The patients were randomized into two groups: Group 1 (n=57) received additional intervention with educational DVD and one teleconference session and Group 2 (n=55) received usual care and were offered the intervention at three months. All patients underwent a final visit at six months. At each visit, the patients completed the BioSecure questionnaire measuring the self-care safety skills, a behavioral intention questionnaire, and the Beliefs about Medicines Questionnaire (BMQ).
Results: No significant difference was observed in the Biosecure score at three months between the two groups (p=0.08). After pooling the first three-month data in Group 1 and the last three-month data in Group 2, the mean score of the BioSecure questionnaire increased to 7.10±0.92 in the group receiving educational intervention (p<0.0001). This increase was maintained at six months in Group 2 (p=0.88). The rate of appropriate behavioral intention increased over time (76% at baseline and 85% at six months for both groups). There was no significant change in the BMQ (p=0.44 to 0.84).
Conclusion: The development of an educational DVD followed by a teleconference seem to improve self-care safety skills of the patients in practical situations.
Serum lysyl oxidase concentration increases in long-standing systemic sclerosis: Can lysyl oxidase change over time?
Authors: Hassan Jokar Mohammad , Jafaripour Simin , Abdollahi Nafiseh , Nazemipour Maryam , Moradzadeh Maliheh , Ali Mansournia Mohammad 
Published: December 2021

Objectives: This study aims to investigate the association of serum lysyl oxidase (LOX) levels with systemic sclerosis (SSc), to examine the relationship between LOX and disease onset, and to evaluate the probable effects of hyperlipidemia on the circulating levels of LOX among patients with SSc.
Patients and methods: Between May 2017 and November 2018, a total of 39 patients with SSc (2 males, 37 females; mean age: 46.6±12.3 years; range, 18 to 65 years) and 35 healthy controls (4 males, 31 females; mean age: 43.1±14.1 years; range, 18 to 65 years) were included. Serum LOX concentration was measured using the enzyme-linked immunoassay in triplicate.
Results: We found higher levels of serum LOX in patients with SSc compared to healthy controls. There was a significant relationship between serum LOX levels and disease onset. Patients with long-standing disease demonstrated increased levels of LOX in the blood compared to the recent-onset group. Hyperlipidemia did not have a significant effect on circulating levels of LOX. There was a significant negative correlation between LOX levels and modified Rodnan Skin Score in the subgroup of patients with skin involvement only and in patients without gastrointestinal involvement.
Conclusion: Our study findings show an increased level of LOX protein level in the blood of patients diagnosed with SSc. Hyperlipidemia seems not to affect the concentrations of LOX in the peripheral blood of patients with SSc.
Relationship between diet, oxidative stress, and inflammation in ankylosing spondylitis
Authors: Tel Adıgüzel Kübra , Gül Yurdakul Fatma , Seremet Kürklü Nilgün , Yaşar Evren , Bodur Hatice 
Published: December 2021

Objectives: This study aims to investigate the relationship between disease activity, dietary phytochemical index (DPI), and serum total oxidant status (TOS) and total antioxidant status (TAS) in patients with ankylosing spondylitis (AS).
Patients and methods: Between August 2020 and January 2021, a total of 37 patients (23 males, 14 females; mean age: 39.3±9.4 years; range, 21 to 61 years) with AS and 36 age-, sex-, and body mass index-matched healthy individuals (24 males, 12 females; mean age: 37.9±8.9 years; range, 20 to 60 years) were included. Serum TAS (μmoLTroloxEq/L) and TOS (μmoL H2O2Eq/L) measurements were performed and the oxidative stress index (OSI) was calculated. Dietary evaluation was made from a one-day dietary record and DPI was calculated.
Results: Serum TAS level in AS patients was significantly lower than the healthy group (p=0.003). Serum TOS level was similar in both groups. The OSI of patients was significantly higher than the controls (p=0.035). The mean DPI, polyunsaturated fatty acid, n-3 fatty acid, and vitamin C intake of patients were significantly lower than controls (p=0.042, p=0.033, and p=0.022, respectively). A moderate positive correlation was found between the TAS level and DPI of the control group (r=0.352, p=0.035). According to medications, no significant difference was seen between the groups in terms of patients’ characteristics, DPI, and laboratory tests and there was no correlation between DPI, TAS, TOS, and OSI.
Conclusion: Lower DPI and lower n-3 fatty acid and vitamin C intake in patient group demonstrated that patients with AS should pay more attention to their diet to increase serum antioxidant status.