bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAPEAMENTO E AVALIAÇÃO DE IMPACTO AMBIENTAL UTILIZANDO AERONAVE REMOTAMENTE PILOTADA NO PARQUE NACIONAL SERRA DE ITABAIANA (BRASIL)
Authors: Rodrigues Jônatas Lemos , Fernandes Milton Marques , Fernandes Márcia Rodrigues de Moura 
Published: February 2021

Com recursos insuficientes o Parque Nacional Serra de Itabaiana (PARNASI), localizado no estado de Sergipe (Região Nordeste do Brasil) apresenta dificuldades de gestão e os maiores problemas estão associados à situação fundiária em que diversos estudos científicos indicam impactos que comprometem seus ecossistemas. O objetivo desse estudo foi realizar um mapeamento de baixo custo sobre o uso e cobertura da terra na área do PARNASI e avaliar o nível de impacto ambiental uma vez que os recursos escassos, a extensão da área do parque e sua topografia representam um desafio para a gestão. Utilizou-se da técnica de fotogrametria aérea com imagens de alta resolução coletadas por meio de um pequeno drone e utilizando um modelo multicritério para a análise de dados, em que as variáveis foram hierarquizadas e ponderadas atribuindo-se um peso para cada classe de uso e cobertura da terra mapeada. Os resultados demonstram que 82,2% da área mapeada possui níveis de declividade considerados entre muito fraco a médio e não possui níveis significativos considerados alto e muito alto de declividade. Todavia, a área em que o nível de impacto foi considerado alto e muito alto está representada pela soma das classes Cultivo e Desmatamento (7,51%), e representa uma área de 5.944 ha. Concluiu-se que a integração das tecnologias utilizadas pode aumentar a escala temporal e espacial sobre o estudo dos padrões e processos de uso e cobertura da terra e pode ser considerada uma estratégia de conservação eficaz para o monitoramento de áreas protegidas.
Desain dan Uji Coba E-Book Berbasis POE (Prediction-Observation-Explanation) Pada Materi Laju Reaksi
Authors: Afrianis Neti , Permata Bunda Intan 
Published: February 2021

This research was instigated by the importance of learning facility technology based for students on Chemistry Subject. It was aimed at knowing the validity and practicality of media that was designed. This research was conducted to the eleventh-grade students of MIPA 6 at State Senior High School 1 Pekanbaru in the Academic Year 2019/2020, and they were 12. It was Research and Development with Borg and Gall modified model. The techniques of collecting the data were observation, interview, questionnaire, and documentation. The final product was in the form of instructional media that was valid. POE (Prediction, Observation and Explanation) based Electronic Book on Reaction Rate lesson had been tested valid by experts of media and material with 90.13% mean percentage (very valid), and practical by 2 Chemistry subject teachers and 12 students with 91.41% mean percentage (very valid). Based on the result, it could be concluded that POE based Electronic Book on Reaction Rate lesson was valid and practical, so the next phase could be tested.
Keywords: Chemistry Instructional Model, Electronic Book, POE (Prediction, Observation and Explanation), Reaction Rate.
SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation
Authors: Dai Xiaofeng , Yu Lihui , Chen Xiao , Zhang Jianying 
Published: February 2021

Abstract
Background: SNRPD1 is a spliceosome-associated protein and has previously been implicated with important roles in cancer development. Methods: Through analyzing the differential expression patterns and clinical association of splicing associated genes among tumor and tumor adjacent samples across different tumors and among different breast cancer subtypes, we identify the tumor promotive role of SNRPD1 using multiple publicly available datasets. Through pathway, gene ontology enrichment analysis and network construction, we linked the onco-therapeutic role of SNRPD1 with cell cycle. Via a series of experimental studies including knockdown assay, qPCR, western blotting, cell cycle, drug response assay, we confirmed the higher expression of SNPRD1 at both gene and protein expression levels in triple negative breast cancer cells, as well as its roles in promoting cell cycle and chemotherapy response.Results: Our study revealed that SNRPD1 over-expression was significantly associated with genes involved in cell cycle, cell mitosis and chromatin replication, and silencing SNRPD1 in breast cancer cells could lead to halted tumor cell growth and cell cycle arrest at the G0/G1 stage. We also found that triple negative breast cancer cells with reduced SNRPD1 expression lost certain sensitivity to doxorubicin whereas luminal cancer cells did not.Conclusions: Our results suggested the prognostic value of SNRPD1 on breast cancer survival, its potential as the therapeutic target halting cell cycle progression for breast cancer control, and warranted special attention on the combined use of doxorubicin and drugs targeting SNRPD1.
Photoacoustic Needle Improves needle Tip Visibility During Deep Peripheral Nerve Block: A Cadaver Study
Authors: Watanabe Kunitaro , Tokumine Joho , Lefor Alan , Nakazawa Harumasa , Yamamoto Katsuya , Karasawa Hiroyuki , Nagase Miki , Yorozu Tomoko 
Published: February 2021

Abstract
Background: We developed a novel technology using the photoacoustic effect that improve needle tip visibility. We evaluated whether this technology improves needle tip visibility when performing a deep peripheral nerve block in a cadaver model.Methods: A photoacoustic needle was developed using a conventional echogenic needle with an intraluminal optical fiber. A pulsed laser sends light from a source through the fiber, which is converted to ultrasound at the needle tip using the photoacoustic effect. A nerve block expert performed deep nerve blocks using the photoacoustic needle and the ultrasound views recorded, with or without photoacoustic ultrasound at the needle tip. Needle tip visibility was evaluated by questionnaire (Likert scale 1 : very poor, 5 : very good) completed by anesthesiologists evaluating recorded images. The score was presented as median [first quartile, third quartile]. Statistical analysis was performed using the Wilcoxon matched-pairs signed rank test. Results: The scores of needle tip visibility with photoacoustic ultrasound from the needle tip (4.3 [ 4.0, 4.5 ]) was significantly higher than that without photoacoustic ultrasound (3.5 [ 3.2, 3.8 ]) (p<0.01). Conclusions: Ultrasound emitted at the needle tip using the photoacoustic effect improves needle tip visibility during deep peripheral nerve blocks.
Challenges, Opportunities, and Potential Roles of the Private Primary Care in Tuberculosis and Diabetes Mellitus (TB-DM) Collaborative Care and Control: A Qualitative Study
Authors: Arini Merita , Sugiyo Dianita , Permana Iman 
Published: February 2021

Abstract
Introduction: TB-DM is a new looming global co-epidemic problem. Despite the Indonesian Government's ongoing effort to put the collaborative TB-DM management regulation in place, it has not taken into account the involvement of private primary care (PPC). This study intended to capture the PPC's existing practices and explore their challenges, opportunities, and potential roles in the collaborative TB-DM services and control.Methods: A descriptive qualitative research design was used to collect data. Two Focus Groups Discussion (FGDs) were conducted with 13 healthcare workers (HCWs) from different private clinics and nine private general practitioners (GPs) from Yogyakarta City, Indonesia. We triangulated the data with the FGDs of HCWs community health centers (CHCs) and in-depth interviews with three regional health regulators. The discussions were audiotaped, transcribed verbatim, and subjected to thematic analysis.Results: PPCs have not been initiated to be involved in the implementation of collaborative TB-DM program. The themes obtained in this study were health system-related barriers, HCWs’ knowledge and perception, un-implemented bi-directional screening, and multisector role needs. The PPCs’ potential roles identified are to conduct health promotion, bi-directional screening, patient referring, and data reporting according to the TB-DM program indicators.Conclusion: Although its involvement in implementing collaborative TB-DM services has yet to be taken into account, the PPC's potential role should not be neglected. Therefore, it is essential to increase their involvement by enhancing their capacity and improving the Public-Private Mix. PPC engagement should be initiated and maintained to ensure the sustainability of the program.
An Iterative Model of The COVID-19 Virus Spread Based on Population Density - A Case Study of Poland
Authors: TWARÓG Bernard 
Published: February 2021

Abstract
The correct recognition of spread patterns of the COVID-19 virus is crucial for effective decision-making on preventive measures to be taken and protection of society. A forecast of hazard development, substantiated by reliable virus propagation models, can support control of the infection risk and minimize its impact on the population. Decisions to close or limit social activities or to lift bans can then be made in the right area at the right time. This study proposes an iterative agent-based and compartmental model used to analyse the COVID‑19 virus spread. The contagion mechanism is based on population density data and Monte Carlo methods. The model parameters were optimized and verified using data about incidence in Poland between March 3 and November 24, 2020. To obtain optimum values of model parameters, a simulation and analysis were completed for three vaccination strategies begun on December 27, 2020. This study contains numerical results and spatial analyses that represent and confirm the accuracy of assumptions of the proposed model. Certain limitations of the proposed approach and planned directions of future work are also indicated in the final section.
Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat
Authors: Oo Swe Mar , Oo Hein Ko , Takayama Hiroaki , Kanamori Takehiro , Takeshita Yumie , Ishii Kiyo-aki , Saito Yoshiro , Matsushita Mami , Okamatsu-Ogura Yuko , Saito Masayuki , Takamura Toshinari 
Published: February 2021

Abstract
Reactive oxygen species (ROS) oxidize and activate the uncoupler protein 1 (UCP1) in brown adipose tissue (BAT) under physiological cold exposure and noradrenaline (NA) stimulation to increase thermogenesis. However, pathological significance and the endogenous regulator of the ROS-mediated BAT activation remain unclear. Here, we show that serum levels of selenoprotein P (SeP, encoded by Selenop) are negatively correlated with BAT activity in humans. SeP impairs UCP1 activity and thermogenesis. Physiological cold exposure downregulates Selenop in BAT. BAT-specific Selenop-deficient (BAT-Selenop KO) mice presented elevated NA-induced mitochondrial ROS production, sulfenylated UCP1, and enhanced thermogenesis and glucose uptake in BAT during cold exposure. SeP inhibits mitochondrial ROS by upregulating the expression of the antioxidant enzyme, glutathione peroxidase 4, and impairs glucose uptake in brown adipocytes. High fat/high sucrose diet upregulates Selenop in the liver and inhibits the NA-induced BAT thermogenesis in BAT-Selenop KO mice. Our data indicate that SeP, as the hepatokine and BATkine, is the first identified intrinsic factor inducing reductive stress that impairs UCP1 activation and thermogenesis in BAT, and therefore may be a potential therapeutic target for obesity and diabetes.
Determination of The Intensity and Georeferencing of Urban Heat Islands in Temuco, Chile
Authors: Martinez-Soto Aner , Vera-Fonseca Michelle , Valenzuela-Toledo Pablo , Melillan-Raguileo Aliwen 
Published: February 2021

Abstract
Various methodologies to estimate the intensity of urban heat islands (UHI) have been proposed. However, there is no consensus on their combined or individual use. This study presents and analyzes the validation of the combined use of methodologies to capture data from UHI’a (mobile transects and fixed stations) and the location of the UHI phenomenon by considering the city of Temuco, Chile as a case study. The database used for the fixed station methodology consists of twenty-three stations belonging to the National Monitoring Network of Chile distributed throughout the city. For the mobile transect methodology the database was generated with three cars that crossed the city simultaneously taking one temperature record per minute. The results show that the two methodologies yield similar results, so it is possible to obtain the intensity of the IHU phenomenon using at least one of them. The results also showed that Temuco has a maximum intensity of the UHI phenomenon of 13°C, with this value being one of the highest recorded in UHI studies in the world.
Toward a Sustainable Municipal Solid Waste Management: Gaps and Challenges in Africa
Authors: Shi Yu , Wang Yao , Yue Yang , Zhao Jun , Maraseni Tek , Qian Guangren 
Published: February 2021

Abstract
This paper comprehensively evaluates the status of municipal solid waste (MSW) management in 54 African countries, with particular attention on MSW generation, collection, disposal, and related legislations from economical and geographical perspectives. By non-spatial data analysis model, the controlling factors that affect the daily MSW generation per capita are determined. The results show the heterogeneity of daily per capita MSW generation across African countries, ranging from 0.1 kg to 1.49 kg in 2016, largely affected by income level, national laws, geographical location and frequency of collection, particularly by GDP per capita and legislation system. The higher MSW generation, collection rates and disposal rate often occurred in economically developed maritime countries. In addition, the wide gap of MSW collection rate not only existed between African countries, but also existed within a country, even in a city, especially for low-income and middle-income countries. Moreover, there was a lack of solid waste regulations in majority Africa countries, and they are poorly implemented while where there are regulations. Based on MSW generation prediction model, the total MSW generation in Africa is expected to triple in 2050, making the future of solid waste management in Africa more challenging.
Neuroprotective Effect of Filgrastim in Animal Models of 3-Nitropropionic Acid &amp; Haloperidol Induced Neurotoxicity in Rats
Authors: Rahi Vikrant , Ram Parladh , KUMAR PUNEET 
Published: February 2021

Abstract
Movement disorders are the heterogeneous group of disorders characterized by the progressive and selective impairment in motor function. Movement disorders like Huntington's disease (HD) and Tardive dyskinesia (TD) share many common features at both cellular and subcellular levels. Filgrastim is a recombinant methionyl granulocyte colony-stimulating factor (GCSF), shows neuroprotective properties in in-vivo models of movement disorders. The present study was designed to evaluate the neuroprotective effect of filgrastimin the animal models of haloperidol and 3-NP induced neurotoxicity in rats. Study was divided in two different protocol, in study one, rats were administered with haloperidol for 21 days, and filgrastim at the dose of (20, 40 & 60 µg/kg,s.c.) was administered once a day, before haloperidol treatment and the following parameters (orofacial movements, rotarod, actophotometer) were assessed for TD. Similarly, in second study rats were administered with 3-NP for 21 days and filgrastimat the dose of (20 & 40 µg/kg, s.c.) was administered, and following parameters (rotarod, narrow beam walk and open field test) were assessed for HD. In each study, on 22nd day, animals were sacrificed, to isolate cortex and striatum for oxidative stress (LPO, GSH, SOD, catalase, and nitrate) parameters. The result revealed that haloperidol and 3-NP treatment significantly impaired motor coordination, oxidative defense and induce TD and HD like symptoms. Filgrastim pre-treatment significantly averted haloperidol & 3-NP induced behavioral and biochemical alterations, respectively. Conclusively, neuroprotective effect of filgrastim is credited to its antioxidant properties, hence filgrastim might be a novel therapeutic candidate to manage TD & HD.
A Retrospective Cross-Sectional Analyses of Swallowing and Tongue Functions in Maxillectomy Patients
Authors: Ogino Yoichiro , Fujikawa Natsue , Koga Sayuri , Moroi Ryoji , Koyano Kiyoshi 
Published: February 2021

Abstract
Purpose
To investigate the profiles of swallowing and tongue functions, and to identify factors influencing swallowing in maxillectomy patients.
Methods
Maxillectomy patients whose swallowing function defined by Eating Assessment Tool (EAT-10) score and tongue functions (oral diadochokinesis: ODK, maximum tongue pressure: MTP) with or without maxillofacial prostheses had been evaluated were enrolled in this study. The effects of the history of radiotherapy or soft palate resection on swallowing function were evaluated. The effect of radiotherapy on oral dryness was also evaluated. To examine correlations of swallowing function with continuous variables, Spearman correlation coefficients were calculated.
Results
A total of 47 maxillectomy patients (23 males and 24 females, median age:71 [IQR: 63–76]) were registered. The median value of EAT-10 scores was 3 [IQR: 0–14]. Patients with the history of radiotherapy, but not with soft palate resection, showed significantly declined swallowing function. ODK and MTP of patients wearing maxillofacial prostheses were significantly improved. No significant effect of radiotherapy on oral dryness was found. A significant correlation was found between EAT-10 score and MTP (P = 0.04).
Conclusions
Swallowing function in maxillectomy patients was relatively impaired and the patients with the history of radiotherapy showed lower swallowing function. Maxillofacial prostheses could contribute to the improvement of MTP and ODK (/ta/). MTP may play a crucial role in swallowing in maxillectomy patients.
A cobalt-organic framework with sensitive detection of Fe3+, Cr2O72–, and CrO42– ions in water
Authors: Zhang Zhen , Sun Han-Xu , Li Shi-Fen , Wang Rui-Dong , Du Lin , Xie Ming-Jin , Zhou Jie , Zhao Qi-Hua 
Published: February 2021

Abstract
A six-coordinated 3D metal–organic framework (MOF), namely, [Co(BPDC)(3-bpdb)(H2O)2]n (1) (H2BPDC = 4,4′-biphenyldicarboxylic acid, 3-bpdb = 1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene) was purposefully constructed and characterized by single-crystal XRD, IR, elemental analyses, PXRD, SEM, and TGA. Crystal structural analysis revealed that the complex consists of a cds-type three-fold interpenetrated framework. Hirshfeld surface analysis yielded details of the surface characteristics of 1. Significant O−H···O hydrogen bonding interactions, which could promote the stability of the framework, were found is extremely stable in aqueous solution and can resist acids and bases over an extensive pH range of 2 - 13. 1 shows brilliant fluorescent emission in the solid state and in aqueous solution. Fluorescence titration, cyclic, and anti-interference experiments demonstrated that 1 is an excellent probe for Fe3+, CrO42‒ and Cr2O72‒ in water. The Ksv values of 1 for Fe3+, CrO42‒, and Cr2O72‒, which were as high as 1.06 × 104 M−1, 1.50 × 104 M−1, and 1.16 × 104 M−1, respectively, were comparable with those of other sensors. The quenching mechanism of the novel probe was subsequently explained.
Workpiece Vibration in Feed Direction Assisted Electrochemical Cutting Using Tube Electrode With Inclined Holes
Authors: Yang Tao , Fang Xiaolong , Hang Yusen , Xu Zhengyang , Zeng Yongbin 
Published: February 2021

Abstract
Electrochemical cutting using tube electrode with inclined holes is a machining method that directly and obliquely injects electrolyte into the machining gap through inclined jet-flow holes on the sidewall of a tube electrode, allowing the electrochemical cutting of a workpiece. To improve the machining efficiency and accuracy of this cutting technique, a method of workpiece vibration in feed direction assisted electrochemical cutting is proposed in which workpiece vibration along the feed direction rapidly and periodically changes the machining gap. The near-instantaneous increases in the machining gap promotes the waste electrolyte containing electrolytic products to flow down the machining gap. At the same time, the electrochemical reaction time under the non-uniform flow field caused by the inclined downward injection of electrolyte is reduced. The flow field simulation of electrolyte in machining gap indicates that the near-instantaneous increases in the machining gap can improve the flow velocity of electrolyte. Experiment demonstrates that the average feed rate can be increased by 50% and the machining efficiency is superior to that of electrochemical cutting assisted by workpiece non-vibration in feed direction. The difference between the upper and lower slit widths is reduced and the machining accuracy is improved. The effect of the vibrational amplitude and frequency on the machining result is also investigated. Finally, an array slice structure is fabricated on a stainless steel block with a cross-section of 10 mm × 10 mm at average feed rate of 6 mm/s using a vibrational amplitude and frequency of 0.1 mm and 1.5 Hz, respectively.
Phase II Study of Propranolol Feasibility With Neoadjuvant Chemotherapy in Patients With Newly Diagnosed Breast Cancer
Authors: Hopson Madeleine B. , Lee Shing , Accordino Melissa , Trivedi Meghna , Maurer Matthew , Crew Katherine , Hershman Dawn , Kalinsky Kevin 
Published: February 2021

Abstract
Purpose: Propranolol regulates angiogenesis in pre-clinical models and reduces distant breast cancer (BC) metastases in observational studies. We assessed the feasibility of combining propranolol with neoadjuvant chemotherapy (NAC) in patients with BC.Methods: Women with clinical stage II-III BC undergoing NAC [weekly paclitaxel x 12, followed by dose-dense adriamycin/cyclophosphamide (AC) x 4] started propranolol 20 mg PO BID with paclitaxel #1, and increased to 80 mg extended release (ER) PO daily, as tolerated. The primary endpoint was to assess feasibility, defined as at least 75% of patients having at least 80% adherence to propranolol as prescribed. Secondary endpoints included identifying safety, rate of dose holds and modification, and rate of reaching 80 mg ER daily. The proposed sample size was 20 patients.Results: From November 2012 to September 2015, ten patients were enrolled. Median age was 50.5 years (range, 44-67). All patients had hormone receptor-positive/HER2-negative breast cancer. Three women had grade I bradycardia that resulted in a 1-week delay in increasing the propranolol dose. Ninety percent of women reached the target propranolol dosing of 80 mg ER daily, and 70% took the target propranolol dose until the night before surgery. Of the 4 women who dose reduced propranolol, 1 increased to the target propranolol dose. Mean adherence to propranolol dosing was 96% (range: 91-100%). All patients went to surgery.Conclusion: Our results support the feasibility of combining propranolol (up to 80 mg ER) with neoadjuvant taxane/anthracycline-based chemotherapy.