bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Diversity among Soybean Genotypes via Yield Attributing Traits and SSR Molecular Markers
Authors: Mishra Nishi , Tripathi Manoj Kumar , Tiwari Sushma , Tripathi Niraj , Gupta Neha , Sharma Akash , Solanki Ravindra Singh 
Published: September 2021

Introduction: As an important source of nutrients to humans and animals, soybean is considered to be a major crop.
Objective: The present study has been executed to identify diverse soybean genotypes on account of different morpho-physiological and microsatellite molecular markers.
Study Design: Data for Morpho-physiological traits were recorded from experiment conducted under field conditions in RBD design whereas molecular work was conducted in Laboratory.
Place and Duration of the Study: The present study was conducted at College of Agriculture, Gwalior, Rajmata Vijayaraje Scindia Krishi Vishwa Vidyalaya, Gwalior, M.P., India during Kharif 2018-19.
Methodology: The study was conducted to document different morphological and physiological traits related to the yield and its attributing traits in soybean. Total 32 microsatellite markers were also used in laboratory to analyze the variability among soybean genotypes.
Results: Morpho-physiological analysis among 53 genotypes revealed the presence of considerable level of variability. Phylogenetic tree based on morpho-physiological traits grouped the genotypes into major and minor cluster. Major cluster had fifty genotypes while minor cluster had only three genotypes. Among polymorphic 32 microsatellite markers, the highest genetic diversity (0.66) was recorded in Satt520 whilst lowest (0.037) was in Satt557 with an average of 0.35. The highest PIC value was 0.59 prearranged by Satt520 and lowest 0.036 by Satt557. An average major allele frequency was 0.69 while, an average PIC value was 0.32. Microsatellite markers-based data also grouped the genotypes into one major and one minor cluster.
Conclusion: Molecular analysis based on microsatellite markers confirms the presence of genetic variability among genotypes under the investigation. Data obtained in the present investigation may contribute towards improvement of soybean genotypes to develop high yielding varieties by considering diverse genotypes with good agronomical traits in hybridization programme.
Study on Vājīkarana Drugs (Aphrodisiacs) for the Promotion of Reproductive Health - A Review
Authors: Liyanage P. L. T. C. , Kulatunga W. M. S. S. K. 
Published: September 2021

Background: Vājīkarana - Aphrodisiacs / Virilification Therapy is one branch of Ashtanga Ayurveda. It deals with preservation and promotion of sexual potency of a healthy man, conception of healthy progeny, and management of sexual and reproductive ailments. Vājīkarana drugs have been selected for the present review due to high prevalence of reproductive disorders among young people below age 40 years, recorded neonatal death caused by congenital anomalies and the urgency of effective medicines in the community.
Objectives: To identify Vājīkarana drugs mentioned in Bhaisajya Rathnavali and analyze the pharmacodynamics properties of commonly used Vājīkarana drugs.
Methodology: The review was mainly based on Vājīkarana drugs mentioned in Bhaisajya Rathnavali by Acharya Govinda Das Sen and commonly used and mostly available drugs have been analyzed according to their pharmacodynamics properties. Collected pharmacodynamics properties from authentic texts and journal articles were tabulated and analysis was done by using SPSS.
Results: Out of 67 Vājīkarana formulae, 208 single drugs were identified which included 83.65% of herbal origin drugs and 74.6% of drug formulae were used to increase the sexual power. 37.3% of the formulae were prepared as Churna (Powder) and most frequently used Anupana (Vehicle) was cow’s milk. Among frequently used & commonly available 10 drugs, Maricha - Piper nigrum has been used in majority of formulae (26.8%). Pharmacodynamics analysis revealed that 80% of drugs were Madhura rasa (sweet in taste), 70% were Guru guna (heavy in property), 70% were Shita virya (cold in potency) and 80% were Madhura vipaka (sweet in post digestive action). Based on modern science, 60% of the drugs had tonic action.
Conclusion: Vājīkarana formulae mentioned in Bhaisajya Rathnavali were mainly used to increase the sexual power of man. Madhura rasa, Guru guna, Shita virya and Madhura vipaka were the pharmacodynamics properties of commonly used drugs in the formulae.
Comparing the Efficacy of 2% Diltiazem Gel with 0.2% Glyceryl Trinitrate in Anal Fissure
Authors: Malik Ehsanullah , Bhatti Sania , Shah Qararo , Abbasi Muharram Ali , Abro Khushbakhat , Shah Vaqar-E-Sahar , Siyal Fahad Jibran , Siyal Dua Rabel , Masood Sumbul , Gopang Abdul Basit , Humayun Arsalan 
Published: September 2021

Objective: To compare the efficacy of 2% diltiazem gel with 0.2% glyceryl trinitrate in patients presenting with chronic anal fissure at Tertiary Care Hospital, Larkana.
Methodology: This prospective comparative Study was conducted at department of Surgery ward-II Chandka Medical Hospital, Larkana from 14-01-19 to 14-07-19. A total of 130 patients who were treated as OPD cases were included in this study. Each patient detailed history & clinical examination, details of symptomatology was recorded in a epically diagnosed proforma. These patients were randomly divided in two equal groups i-e group A 65 patients and group B 65 patients. Group A patients were treated with 02% glyceryl trinitrate and group B patients were treated with diltiazem gel 02%. All the patients of group A & B were followed up to 02 months after start of leadema as a OPD cases.
Results: A total of 130 patients (65 each in 2% diltiazem gel with 0.2% glyceryl trinitrate group) were included. Mean age in both groups was 42.56±3.91 and 41.71±4.01. 46 (70.8%) and 19 (29.2%) were male and female in Group A and 39 (60%) and 26 (40%) were male and female in Group B. Efficacy of 2% diltiazem gel with 0.2% glyceryl trinitrate in patients presenting with chronic anal fissure was 76.9% and 50.8% respectively.
Conclusion: DTZ (2%) and GTN (0.2%) are equally effective in healing anal fissures. DTZ is better than GTN as it causes less side effects, low recurrence rate, healing rate and therefore better compliance.
Development, Validation and Forced Degradation Study of Emtricitabine and Tenofovir Alafenamide in its Pharmaceutical Dosage Form Using RP-HPLC
Authors: Patel Khushboo , Shah Ujashkumar , Joshi Hirak , Patel Jayvadan K. , Patel Tejas B. 
Published: September 2021

Aims: The present research was aimed to develop and validate a reverse phase high performance liquid chromatographic (RP-HPLC) method for the quantification of Emtricitabine (EMT) and Tenofovir Alafenamide (TEN) in combination.
Methodology: Separation was achieved under optimized chromatographic condition on an Inertsil C18, 250 x 4.6 mm, 5μm column. Various composition of mobile phase was tried. Separation of EMT and TEN was started with Methanol: Buffer and Methanol finally using solvent system of Buffer (pH 3.5) and Methanol in ratio of (30:70) and flow rate adjust at 1.0 ml/min was used as solvent system, the detection was carried out at 262nm using Shimazdu UV-visible detector. The mobile phase run time for the developed analytical method was 10 minutes.
Results: The standard curve was found linear in the concentration range of 20-60 μg/ ml (r2- 0.9994) and 2.5-7.5 μg/ ml (r2-0.9992) for EMT and TEN respectively. The %RSD was found to be 0.80-0.95% and 0.63-1.09 for EMT and TEN respectively. Percentage (%) recoveries for EMT and TEN to be in range of 100%-100.6% and 99.32%-100.83% respectively. The limit of detection and the limit of quantification were found to be 4.80 μg/ ml and 14.7 μg/ ml respectively for EMT and 0.11 μg/ ml and 0.33μg/ ml respectively for TEN. Results of forced degradation study showed EMT degradation in acid and base medium while TEN was showed degradation in oxidative stress. The proposed developed RP-HPLC method was validated statistically and the values were found to be within the acceptable limits.
Conclusion: In conclusion, the developed RP-HPLC method was found to be simple, specific, and rugged for simultaneous estimation of EMT and TEN. Validation results of method was found within the acceptable limits. Hence it can be used for analysis of EMT and TEN.
The Impact of Parental Substance Abuse and Psychosocial Behaviour of Children in Age Group of 6-12 years: School Based Study
Authors: Walke Monali , Waghmare Nikita , Waghmare Priya , Vaitage Mamata , Umate Shiwani , Tendulakar Vaishali 
Published: September 2021

Aim of the study is 1. Find out the extent of reported parental substance abuse 2. Assess the psychosocial development of child 3. Assess the perceived impact of parental substance abuse on psychosocial development of children.
Methodology: The study was conducted in the school of Wardha district, Maharashtra, India. Population: School going children of age 6-12yrs and their parents. 200 sample size was selected, each 100 parent and 100 children. Non-probability convenient sampling technique used. A structured questionnaire used for both parent and their children separately.
Results: The reported prevalence rate of parental substance abuse as reported by children shows the ratio as: The rate of no substance abusers which scores from 0-12 of frequency (14) is 14%.The rate of Borderline abusers which scores from 13-24 of frequency (23) is 23%. The rate of Mild abusers which scores from 25-36 of frequency (22) is 22%.The rate of Moderate abusers which scores from 37-48 of frequency (23) is 23%.The rate of Severe abusers which scores from 49-60 of frequency (18) is 18%. The reported prevalence rate of parental substance abuse as reported by parent shows the ratio as: The rate of no substance abusers which scores from 0-9 of frequency (6) is 6%. The rate of Borderline abusers which scores from 10-18 of frequency (24) is 24%. The rate of Mild abusers which scores from 19-27 of frequency (28) is 28%. The rate of Moderate abusers which scores from 28-36 of frequency (18) is 18%. The rate of Severe abusers which scores from 37-44 of frequency (26) is 26%. Psychosocial behaviour of children which reveals that most of the children will act as crying or will get angry which is an age appropriate behaviour.
Triboelectric Polymer with High Thermal Charge Stability for Harvesting Energy from 200 °C Flowing Air
Authors: Tao Xinglin , Li Shuyao , Shi Yuxiang , Wang Xingling , Tian Jingwen , Liu Zhaoqi , Yang Peng , Chen Xiangyu , Wang Zhong Lin 
Published: September 2021

AbstractDue to the thermionic emission effect, the electron transferred to dielectric surface can be released into vacuum after the contact electrification (CE). Therefore, triboelectric nanogenerator (TENG) cannot maintain effective electrical output under high temperature conditions. In order to obtain high thermal charge stability, polyimide is modified with strong electron withdrawing groups like trifluoromethyl (CF3) and sulfone group (SO2) in backbone. The fluorinated polyimides (F‐PI) with a big band gap can provide a tribocharge density of 170 µC m−2 (4 times of common Kapton film) and become more negative than polytetrafluoroethylene in triboelectric series. In addition, BaTiO3 nanoparticles are doped in F‐PI film for inducing deep traps and interfacial polarizations for CE, which can further enhance the charge density (200 µC m−2) and thermal charge stability. Finally, a flutter‐driven TENG (FD‐TENG) is designed based on this BaTiO3‐doped F‐PI film to harvest wind energy and sense wind velocity. This FD‐TENG can maintain 32% of its output performance at 200 °C in comparison with room temperature, which is the highest thermal charge stability reported for triboelectric polymers. Therefore, this BaTiO3‐doped F‐PI has great application prospects for energy generation and motion detection in hot wind tunnel and many other harsh environments.
Substrate‐Controlled Chemo‐/Enantioselective Synthesis of α‐Benzylated Enals and Chiral Cyclopropane‐Fused 2‐Chromanone Derivatives
Authors: Byeon Huimyoung , Ryu Sunghyeon , Yoo Eun Jeong , Yang Jung Woon 
Published: September 2021

AbstractSubstrate‐controlled cascade reactions between α,β‐unsaturated aldehydes or their analogues and 2,4‐dinitrobenzyl chloride in the presence of a chiral secondary amine as the catalyst and base were developed, to obtain a broad spectrum of α‐benzylated enals and enantioenriched cyclopropane‐fused chroman‐2‐one derivatives. The cyclopropane‐tethered iminium ion clearly served as a key intermediate in these reactions to trigger stereochemical outcomes, one of which was supported by a control experiment.magnified image
Determining occupation for National Violent Death Reporting System records: An evaluation of autocoding programs
Authors: Davis Jonathan , Peek‐Asa Corinne , Dale Ann Marie , Zhang Ling , Casteel Carri , Hamann Cara , Evanoff Bradley A 
Published: September 2021

AbstractBackgroundSuicide is a leading cause of death for working‐age adults. Suicide risk varies across occupations. The National Violent Death Reporting System (NVDRS) collects information about violent deaths occurring in the United States. Occupation can be determined using autocoding programs with NVDRS data. The objective of this analysis is to determine the accuracy of autocoding programs for assigning occupations in the NVDRS.MethodsDeaths from suicide were identified in NVDRS for individuals age 16 and older from 2010 to 2017. Occupations were assigned after processing job description free text with autocoding programs. Job assigned by autocoding program were compared with the occupation code recorded on the death certificate.ResultsAssignment of major occupation group had substantial agreement (Cohen's kappa > 0.7) for the two autocoding programs evaluated. Agreement of assigned code varied across race/ethnicity and occupation type.ConclusionsAutocoding programs provide an efficient method for identifying the occupation for decedents in NVDRS data. By identifying occupation, circumstances of suicide and rates of suicide can be studied across occupations.
Financing decisions in a supply chain when considering product returns
Authors: Luo Qinglin , Luo Jianwen 
Published: September 2021

AbstractAs more and more products are sold, the management of product returns plays a significant role in firms' operational decisions. We consider a capital‐constrained newsvendor model to explore the impact of product returns on firms' operational and financial decisions, in which a capital‐constrained retailer can get financed from either banks or suppliers and refurbish returned products and resell them to customers. Our findings show that offering refurbishment for returned products can increase the retailer's order quantity and improve the capital‐constrained supply chain performance. Moreover, the supplier strategically designs the wholesale price to hinder the retailer refurbishing returned products although the retailer always chooses to provide refurbishment under trade credit. When only trade credit financing is available, there exists a Pareto improvement on both partners' profits under certain cases. In addition, we investigate the financing preferences of the supply chain and find that product returns have a significant influence on the unique financing equilibrium. Finally, we conduct numerical analyses to present the impacts of some key parameters on the performance of both supply chain members.
Sortase A: A chemoenzymatic approach for the labeling of cell surfaces
Authors: Kumari Poonam , Bowmik Sujoy , Paul Sudipto Kumar , Biswas Bidisha , Banerjee Sanjay K. , Murty Upadhyayula Surayanarayana , Ravichandiran Velayutham , Mohan Utpal 
Published: September 2021

AbstractSortase A, a transpeptidase enzyme is present in many Gram‐positive bacteria and helps in the recruitment of the cell surface proteins. Over the last two decades, Sortase A has become an attractive tool for performing in vivo and in vitro ligations. Sortase A‐mediated ligation has continuously been used for its specificity, robustness, and highly efficient nature. These properties make it a popular choice among protein engineers as well as researchers from different fields. In this review, we give an overview of Sortase A‐mediated ligation of various molecules on the cell surfaces, which can have diverse applications in interdisciplinary fields.
Identification of the Catalytic Residues in the Cyclase Domain of the Class IV Lanthipeptide Synthetase SgbL
Authors: Hegemann Julian D. , Süssmuth Roderich D. 
Published: September 2021

AbstractLanthipeptides belong to the family of ribosomally synthesized and post‐translationally modified peptides (RiPPs) and are subdivided into different classes based on their processing enzymes. The three‐domain class IV lanthipeptide synthetases (LanL enzymes) consist of N‐terminal lyase, central kinase, and C‐terminal cyclase domains. While the catalytic residues of the kinase domains (mediating ATP‐dependent Ser/Thr phosphorylations) and the lyase domains (carrying out subsequent phosphoserine/phosphothreonine (pSer/pThr) eliminations to yield dehydroalanine/dehydrobutyrine (Dha/Dhb) residues) have been characterized previously, such studies are missing for LanL cyclase domains. To close this gap of knowledge, this study reports on the identification and validation of the catalytic residues in the cyclase domain of the class IV lanthipeptide synthetase SgbL, which facilitate the nucleophilic attacks by Cys thiols on Dha/Dhb residues for the formation of β‐thioether crosslinks.
Spontaneous recovery of immune checkpoint inhibitor‐induced thyroiditis with high free T4 level: A case report
Authors: Hagiwara Rie , Suzuki Daisuke , Tonezawa Shiori , Saikawa Rika , Funazaki Shunsuke , Yoshida Masashi , Washino Satoshi , Miyagawa Tomoaki , Hara Kazuo , Yamada Hodaka 
Published: September 2021

AbstractWe describe a case of severe hyperthyroidism with high free thyroxine and C‐reactive protein levels, wherein thyroid function rapidly improved without treatment. In a similar case, conservative management with imaging follow‐up can be considered.
Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge
Authors: Soleja Mohsin , Jaso Jesse Manuel , Chen Weina , Raisanen Jack , Wysocki Christian A. , Shen Yu‐Min , Mickey Bruce , Kumar Kiran A. , Ramakrishnan Geethakumari Praveen 
Published: September 2021

AbstractIsolated central nervous system lymphomatoid granulomatosis (CNS‐LYG) can mimic aggressive glioblastomas. We describe a complex presentation of CNS‐LYG coexisting with immune thrombocytopenia successfully managed with rituximab and ultra‐low‐dose radiation therapy.
Synthesis and Characterisation of Luminescent [CrIII2L(μ‐carboxylato)]3+ Complexes with High‐Spin S=3 Ground States (L=N6S2 donor ligand)
Authors: Börner Martin , Klose Jennifer , Gutierrez Suburu Matias E. , Strassert Cristian A. , Yang Fangshun , Monakhov Kirill Yu. , Abel Bernd , Kersting Berthold 
Published: September 2021

AbstractThe synthesis, structure, magnetic, and photophysical properties of two dinuclear, luminescent, mixed‐ligand [CrIII2L(O2CR)]3+ complexes (R=CH3 (1), Ph (2)) of a 24‐membered binucleating hexa‐aza‐dithiophenolate macrocycle (L)2− are presented. X‐ray crystallographic analysis reveals an edge‐sharing bioctahedral N3Cr(μ‐SR)2(μ1,3‐O2CR)CrN3 core structure with μ1,3‐bridging carboxylate groups. A ferromagnetic superexchange interaction between the electron spins of the Cr3+ ions leads to a high‐spin (S=3) ground state. The coupling constants (J=+24.2(1) cm−1 (1), +34.8(4) cm−1 (2), H=−2JS1S2) are significantly larger than in related bis‐μ‐alkoxido‐μ‐carboxylato structures. DFT calculations performed on both complexes reproduce both the sign and strength of the exchange interactions found experimentally. Frozen methanol‐dichloromethane 1 : 1 solutions of 1 and 2 luminesce at 750 nm when excited into the 4LMCT state on the 4A2 → 2T1 (ν2) bands (λexc=405 nm). The absolute quantum yields (ΦL) for 1 and 2 were found to be strongly temperature dependent. At 77 K in frozen MeOH/CH2Cl2 glasses, ΦL=0.44±0.02  (for 1), ΦL=0.45±0.02  (for 2).
Anisotanols A—D, Four Norsesquiterpenoids with an Unprecedented Sesquiterpenoid Skeleton from Anisodus tanguticus‡
Authors: Zhao Hao‐Yu , Zhou Qin‐Mei , Zhu Huan , Zhou Fei , Meng Chun‐Wang , Shu Hong‐Zhen , Liu Zhao‐Hua , Peng Cheng , Xiong Liang 
Published: September 2021

Main observation and conclusionAnisotanols A—D (1—4), four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system, were obtained from Anisodus tanguticus. Their structures were elucidated by comprehensive spectroscopic techniques, and the absolute configurations were confirmed via ECD calculations and single‐crystal X‐ray diffractions. A putative biosynthetic pathway for these compounds was proposed. Biological evaluation disclosed that compound 3 showed anti‐angiogenic activity by inhibiting the viability, migration, and tube formation in HUVECs.
Phone consultation and burnout among providers of dialectical behaviour therapy
Authors: Ruork Allison K. , Yin Qingqing , Fruzzetti Alan E. 
Published: September 2021

AbstractAdherent dialectical behaviour therapy (DBT) includes between‐session phone consultation to help clients generalize skills, solve problems during crises, and repair relationships. Despite benefits of phone consultation, it is frequently not implemented in outpatient settings. The perceived burden phone consultation places on providers is one of the most frequently cited reasons for its omission. The current study examined phone consultation in relation to providers' burnout using a cross‐sectional design. We hypothesized that (1) DBT experience and support from peer consultation team members, including perceived team efficacy and shared coaching responsibilities, would be associated with lower rates of burnout and (2) higher numbers of crisis contacts and “other” contacts, but not noncrisis skills generalization contacts, would be associated with increased burnout. Participants were 65 DBT therapists who completed an anonymous survey online. Results suggest that both having more effective consultation teams and sharing phone consultation among team members were associated with decreased burnout. Additionally, more crisis contacts were found to be associated with higher burnout, whereas higher number of skills generalization calls was not. This study represents an important first step towards evaluating the impact of phone consultation on providers and highlights the importance of effective peer consultation in reducing therapist burnout.