bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rockwood Grade-III Acromioclavicular Joint Separation
Authors: Franovic Sreten , Pietroski Alex , Kuhlmann Noah , Bazzi Talal , Zhou Yang , Muh Stephanie 
Published: May 2021

Background:
The treatment of Rockwood Grade-III acromioclavicular (AC) joint separation has been widely disputed since the introduction of the classification system. The present literature does not reach consensus on whether operative or nonoperative management is more advantageous, nor does it effectively distinguish between operative measures. We hypothesized that nonoperative treatment of Rockwood Grade-III AC joint separation would be more cost-effective when compared with surgical options.

Methods:
We created a decision-tree model outlining the treatment of Rockwood Grade-III separations using nonoperative management or hook-plate, suture-button, or allograft fixation. After nonoperative intervention, the possible outcomes predicted by the model were uneventful healing, delayed operative management, a second round of sling use and physical therapy, or no reduction and no action; and after operative intervention, the possible outcomes were uneventful healing, loss of reduction and revision, and depending on the implant, loss of reduction and no action, or removal of the implant. A systematic review was conducted, and probabilities of each model state were averaged. A cost-effectiveness analysis was conducted both through rollback analysis yielding net monetary benefit and through incremental cost-effectiveness ratios (ICERs). Thresholds of $50,000/quality-adjusted life-year (QALY) and $100,000/QALY were used for ICER analysis. Furthermore, a sensitivity analysis was utilized to determine whether differential probabilities could impact the model.

Results:
Forty-five papers were selected from a potential 768 papers identified through our literature review. Nonoperative treatment was used as our reference case and showed dominance over all 3 of the operative measures at both the $50,000 and $100,000 ICER thresholds. Nonoperative treatment also showed the greatest net monetary benefit. Nonoperative management yielded the lowest total cost ($6,060) and greatest utility (0.95 QALY). Sensitivity analysis showed that allograft fixation became the favored technique at a willingness-to-pay threshold of $50,000 if the rate of failure of nonoperative treatment rose to 14.6%. Similarly, at the $100,000 threshold, allograft became dominant if the probability of failure of nonoperative treatment rose to 22.8%.

Conclusions:
The cost-effectiveness of nonoperative treatment is fueled by its notably lower costs and overall high rates of success in Grade-III separations. It is important to note that, in our analysis, the societal cost (measured in lost productivity) of nonoperative treatment neared that of surgical treatment, but the cost from the health-care system perspective was minimal. Physicians should bear in mind the sensitivity of these conclusions and should consider cost-effectiveness analyses in their decision-making guidelines.

Level of Evidence:
Economic and Decision Analysis Level IV. See Instructions for Authors for a complete description of levels of evidence.
Una traductora pionera de linaje real y ascendencia alemana: Sor Constanza de Castilla (s. XV)
Authors: Cuéllar Lázaro Carmen 
Published: May 2021

El objetivo de este artículo es sacar a la luz la figura de Sor Constanza de Castilla (s. XV), una de las primeras traductoras en lengua castellana. Esta monja dominica es un ejemplo de cómo en esa época las mujeres pudieron acceder a un nivel cultural desde el que se iniciaron como escritoras y traductoras, dentro de la vida monacal y en el seno de la aristocracia. Sor Constanza de Castilla, de linaje real y ascendencia alemana, fue una influyente y poderosa priora que, en el seno del convento, no sólo compuso oraciones y obras devotas, sino que también fue recopiladora de textos y traductora, faceta esta última que más nos interesa poner en valor en este estudio. En esta investigación analizamos su obra, el manuscrito Devocio y Oficios, que se conserva en la Biblioteca Nacional de Madrid y que servía para la oración y el canto de los oficios a las monjas de su convento. Esta religiosa combina en su devocionario la formación y la doctrina, los dos ejes del carisma de la comunidad religiosa a la que pertenece, la Orden de Predicadores. En una vida dedicada a la oración dentro del claustro, las traducciones, como parte esencial del manuscrito, se convierten en un aspecto central de la existencia diaria de la comunidad.
Palabras clave: Traducción monacal, Traductor religioso, Traductor dominico, Orden Dominica, Orden de Predicadores, Sor Constanza de Castilla.
Lenguaje inclusivo y representación del colectivo queer en solicitudes de adopción: análisis contrastivo inglés-español
Authors: Rodríguez-Arcos Irene , González Díaz Andrea 
Published: May 2021

El lenguaje inclusivo constituye una forma simbólica de definir pertenencia a una comunidad o un intento de reflejar identidades y orientaciones que van más allá de la visibilidad de la mujer. Aunque se abren camino diferentes estrategias para lograr una mayor representación de ciertos colectivos, no todas resultan igual de aceptables en lo que se refiere a la esfera administrativo-legal. Justificando la posibilidad teórica de desestabilizar el género y la responsabilidad ética de reconocer todo el espectro que abarcan las siglas LGTBIQ+, se estudia una muestra compuesta por documentos de adopción en español y en inglés, que permitirá observar hasta qué punto se logra contemplar la presencia de una comunidad que es susceptible de tener que recurrir a estos instrumentos legales. Además de comprobar la efectividad de las estrategias utilizadas en ambas lenguas con propuestas fundamentadas desde el plano de la Lingüística, como la de Grijelmo, se reflexionará acerca de qué fórmulas resultan aceptables en este contexto específico de uso, en el que, si bien es cierto que se han producido algunos avances, aún queda camino por recorrer. No obstante, ambas lenguas disponen de mecanismos propios del lenguaje administrativo-legal que no obligan a incorporar neologismos ni dobletes y están perfectamente asentadas socialmente, por lo que se defiende la necesidad de estudiarlas e incluirlas para lograr un reconocimiento que el colectivo aún lucha por conseguir.
Palabras clave: Lenguaje inclusivo, Género, LGTBIQ+, Hospitalidad, Performatividad.
Las redes colaborativas con stakeholders en la innovación y la sostenibilidad de las empresas turísticas
Authors: NAVA-ROGEL ROSA MARÍA , DEMUNER-FLORES MARÍA DEL ROSARIO 
Published: May 2021

Uno de los sectores más afectados por la crisis sanitaria y económica provocada por el COVID-19 es el turístico, ya que la demanda por estos servicios ha caído drásticamente. Esto podría empeorar si no se consideran los cambios en el comportamiento del turista, que involucra la demanda de productos sustentables. El objetivo de este trabajo es identificar el valor de la información generada por las redes que tiene la industria turística con los stakeholders en el desarrollo de innovaciones sustentables. Se realizó un análisis bibliométrico de artículos científicos de alto impacto que abordaron el tema del 2000 a 2020, con evidencia sobre el uso de redes de conocimiento con stakeholders como fuente de información externa. Los hallazgos demuestran que los clientes, proveedores y competidores, son las fuentes más utilizadas en el desarrollo de innovaciones. Sin embargo, los pobladores del lugar en donde se instala la empresa turística generan información de mayor utilidad para desarrollar innovaciones sustentables con el entorno y con la comunidad, ya que son los que tienen mayor conocimiento sobre los problemas que implica el cuidado del medio ambiente de manera cercana, saben sobre las raíces culturales, artísticas y artesanales del lugar y se involucran con su entorno.
Palabras clave: innovaciones sustentables; capacidad de absorción; redes de conocimiento; stakeholders; turismo; COVID-19.
A Deep Learning Based Method for Forecasting Gold Price with Respect to Pandemics
Authors: Khani Mahtab Mohtasham , Vahidnia Sahand , Abbasi Alireza 
Published: May 2021

Abstract
The spread of COVID-19 in the world had a devastating impact on the world economy, trade relations, and globalization. As the pandemic advances and new potential pandemics are on the horizon, a precise analysis of recent fluctuations of trade becomes necessary for international decisions and controlling the world in a similar crisis. The COVID-19 pandemic made a new pattern of trade in the world and affected how businesses work and trade with each other. It means that every potential pandemic or any unprecedented event in the world can change the market rules. This research develops a novel model to have a proper estimation of the stock market values with respect to the COVID-19 dataset using long short-term memory networks (LSTM). The nature of the features in each pandemic is completely different, thus, prediction results for a pandemic by a specific model cannot be applied to other pandemics. Hence, recognizing and extracting the features which affect the pandemic is the highest priority. In this study, we develop a framework, providing a better understanding of the features and feature selection. Although the global impacts incurred by COVID-19 are complicated, here we are trying to show how additional features like COVID-19 rather than the history of tickers, which is used conventionally for prediction, cab help forecasting in a real-world scenario. This study is based on a preliminary analysis of such features for enhancing forecasting models' performance against fluctuations in the market. Our forecasts are based on the market value data and COVID-19 pandemic daily time-series data (i.e. the number of new cases). In this study, we selected Gold price as a base for our forecasting task which can be replaced by any other markets. We have applied Convolutional Neural Networks (CNN) LSTM, Vector Output Sequence LSTM, Bidirectional LSTM, and Encoder-Decoder LSTM on our dataset, and our results achieved an MSE of 6.0e-4, 8.0e-4, and 2.0e-3 on the validation set respectfully for one day, two days, and 30 days predictions in advance which are outperforming other proposed method in the literature.
The interaction of migration range, regional economic development level on social capital and public health services of internal migrants: evidence from the China Migrant Dynamic Survey in 2017
Authors: Yang Zhen , Jiang Chenghua 
Published: May 2021

Abstract
Objectives Studies have confirmed that both migration range (MR) and regional economic development level (REDL) have significant impacts on the accessibility of National Essential Public Health Services (NEPHS) for the internal migrants (IMs), but no studies have explored the interaction between MR and REDL, nor discussed the mechanism behind their influence.Method A sample of 115412 respondents from the China Migrant Dynamic Survey in 2017 was adopted, aged 18-59 years and residence duration more than one year. Beijing, Tianjin and Shanghai were excluded. The MR was divided into inter-provincial and intra-provincial migration. Social capital (SC) was divided into cognitive social capital (CSC) and structural social capital (SSC). The REDL was divided into high income provinces (HIPs) and low-middle income provinces (LMIPs). Cross-table, chi-square test, logistic regression and other statistical methods were used to analyze impacts of MR and REDL on IMs' SC, awareness of NEPHS and establishment of health records (EHR).Results (1) The SC of inter-provincial IMs is always lower than that of intra-provincial IMs. The CSC of IMs in HIPs is lower but their SSC is not the same. The MR difference of IMs' SC is greater in HIPs. (2) The IMs' level of NEPHS utilization in the inter-provincial group and the HIPs group is lower, and the MR difference of IMs' level of NEPHS utilization is greater in the HIPs. (3) The IMs' SC can significantly promote their NEPHS utilization level, but this relationship is affected by the dimensions of SC, MR and REDL.Conclusions MR and REDL may affect the IMs' SC through cultural exclusion and institutional exclusion, and further affect the IMs' NEPHS utilization. When promoting equalization of NEPHS in HIPs, it is necessary for HIPs to expand more primary health facilities to increase the NEPHS supply, and take measures to stimulate the inter-provincial IMs' sense of identity and social participation.
Card Sorting: A new pedagogy for understanding challenges in Mathematics during Emergencies and Crises
Authors: Paea Sione , Sharma Bibhya , Bulivou Gabiriele , Paea Mele Katea 
Published: May 2021

Abstract
Interest in challenges faced by university students during COVID-19 has led to research and development initiatives that include educational, technological, economical and socio-cultural provisions. Despite these initiatives, little is known about the usage of open card sorting, similarity matrix, and Hierarchical Clustering Method - 3D Cluster View algorithm in understanding and analysing mathematics challenges in a regional university during emergencies and crisis. This paper presents findings from a study that explored the challenges encountered by first-year mathematics students in a South Pacific institution. The findings reveal seven challenges: i) financial hardship; ii) motivational challenge; iii) moodle issues; iv) lack of face to face interactions; v) problem with course delivery; vi) internet challenge; and vi) home disturbances. A heptagon model is presented with possible solutions for the challenges identified by participants. The findings point to the complex inter-relationship between the institution’s emergency remote teaching, students’ learning needs, and students’ dynamic socio-cultural environments as important factors for delivering quality mathematics learning during a pandemic. This paper highlights the contribution of card sorting, as a new pedagogy, to the field of educational research as a provider of new learning analytics for desirable learning outcomes in a given pandemic. Decisionmakers and Policymakers of Higher Education Institutions around the world may benefit from these findings while formulating strategies to support first-year mathematics students during the current and future pandemics.
A single-nucleotide polymorphism involved in alternative splicing of PTEN is associated with chemotherapy resistance in breast cancer in Chinese population
Authors: Wang Jing , Zhang Shasha , Zhang Zhongliang , Ma Qinglong , Chen Xiaohua , Zhao Dapeng , Zhao Meie , Wang Chunwei , Di Cuixia , xie xiaodong 
Published: May 2021

Abstract
Background: Chemoresistance is still the main reason for the failure of breast cancer treatment and is the main cause of death of breast cancer patients. Although many studies have shown the association between genetic polymorphisms of PTEN and chemotherapy resistance, the molecular mechanism of breast cancer chemotherapy has not been further studied. This study aims to investigate the potential association between PTEN gene polymorphism and breast chemotherapy resistance in the Chinese population, and explore whether alternative splicing of the PTEN gene is affected by the gene polymorphism. Methods: The study included 234 patients with breast cancer chemotherapy, 157 chemotherapy sensitive cases and 77 chemotherapy resistant cases. rs786204926 of PTEN gene was analyzed by Sanger sequence and Sequenom MassArray typing technology. Furthermore, we used silicon analysis to predict whether polymorphism affects the process of alternative splicing and to analyze how it affects. Results: In genotyping and allelic analysis, there was a significant association between rs786204926 polymorphism and breast cancer chemotherapy resistance. Carrying the G allele or AG genotype will reduce the risk of breast cancer-based resistance to chemotherapy with anthracyclines. Silicon analysis showed that the mutation of rs786204926 produced a new receptor site, which might affect alternative splicing of PTEN gene. Conclusions: We speculate that the mechanism of breast cancer chemotherapy resistance might be caused by a change in the alternative splicing caused by the rs786204926 of the PTEN gene. Thus, our study might provide theoretical guidance for the individualized treatment of clinical breast cancer patients.
Transfer and accumulation of cadmium in soil, forages and animals: Risk assessment
Authors: Sultana Razia , Ge Xiaoping , Chen Fu , Anwar Sidra , Ma Jing , Ahmad Kafeel , Khan Zafar Iqbal , Ashfaq Asma , Nadeem Muhammad , Ahmed Tasneem , Ugulu llker 
Published: May 2021

Abstract
Over past several years pollution in industrialized areas is the most attention seeking issue. Higher level of heavy metals especially cadmium is accumulated in atmosphere evolved from smoke of automobiles. Living system present around the contaminated areas accumulate heavy metals in their bodies. Heavy metals have been accumulated in soil, water, forages and animals so study was conducted in industrialized area Faisalabad to evaluate the possible risk. Three sites was selected to check the accumulation of cadmium in soil, water, forages and animals. These sampling sites was areas along the roadsides of Chak Jhumra, Jaranwala and Samundri. Sample of soil, forages,water and blood,hair feces of animals was collected from these sites. The digestion of samples was carried out with the help of nitric acid and hydrogen peroxide. Atomic absorption spectrophotometer was used to evaluate heavy metal analysis. Analysis of variance was done by using SPSS Software (version no. 20) and two ways ANOVA. Result indicated that concentration of Cd was higher in soil irrigated with municipal wastewater and concentration of Cd was highest in forages C. album present at site III. Higher concentration of Cd was observed in blood of sheep higher than critical value. Concentration of cadmium was higher than critical in blood of animals indicating transfer of metal via intake of contaminated forages. The sample collected from site III showed high daily intake of metals (DIM), health risk index (HRI), pollution load index (PLI), enrichment factor (EF) and Bioconcentration factor (BCF). This study will bring consideration concerning the development of approaches in order to overcome the toxic effects of cadmium.
Analytical, Numerical and Experimental Study of an Enhanced Nonlinear Energy Sink
Authors: Geng Xiao-Feng , Ding Hu 
Published: May 2021

Abstract
Based on theoretical and experimental investigations, this paper proposes a nonlinear energy sink (NES) with piecewise linear springs to enhance vibration suppression effects. A cubic nonlinear oscillator is coupled with a piecewise linear spring to form an enhanced NES (E-NES). Without adding a new resonance region and changing the resonance frequency of the primary system, the enhanced NES can achieve better vibration suppression effects. Based on the free vibration and the forced vibration, the influence of piecewise linear stiffness on the vibration suppression is profoundly examined. The results show that the E-NES has a better suppression effect on the vibration of the primary structure than that of the cubic NES in most cases. Furthermore, the piecewise stiffnesses and gap displacements are optimized through the differential evolution algorithm. The best damping effect of the E-NES on the free vibration is presented. However, it also happens that the vibration suppression effect of the E-NES is weaker than that of the conventional NES. Moreover, the experimental results verify the analytical and numerical results. The vibration elimination efficiency of the E-NES exceeds 90%. Therefore, this research on using piecewise springs to enhance the vibration suppression efficiency will attract attention.
Left Atrium With Dysphagia:Case Report
Authors: Song qing , Wang Xiaoyong , Jia Chuanliang , Mou Yakui , Song Xicheng 
Published: May 2021

Abstract
Background: Left atrium in 27 to 38 mm is normal and over 80mm is called giant left atria. Giant left atria is mostly caused by rheumatic mitral valve regurgitation. Pain, dysphagia and reflux are the common symptoms. Case presentation: We report a case with dysphagia for the reason of rheumatic heart disease with left atrium enlargement. He also had difficulty swallowing, but never had an inability to eat. And further the inner diameter did not fit the standard of giant left atria, but there was obvious compressive symptom of the esophagus and severe stricture of the esophageal lumen. Conclusions: There are many reasons for dysphagia, which need to be analyzed on a case-by-case basis. The patient with dysphagia after eating is likely to be confused with an esophageal foreign body, and a careful history should be taken.
Whole Exome Sequencing as a Diagnostic Tool of Primary Complement Component Deficiencies: A Multicenter Experience of Three Novel Mutations
Authors: Shamriz Oded , Simon Amos J , Frizinsky Shirly , Megged Orli , Barel Ortal , Tal Yuval , Somech Raz , Toker Ori 
Published: May 2021

Abstract
Diagnosis of primary complement deficiencies requires a high index of suspicion. Thus, susceptible patients are often underdiagnosed and untreated. Here, we present a multi-center experience with three novel inborn errors of the classical complement system. This is a retrospective multicenter analysis of computerized medical records of children (> 18 years) admitted in the period between 2003 and 2018 at Shaare Zedek Medical Center in Jerusalem and Edmond and Lily Safra Children's Hospital, Tel-Hashomer Medical Center, in Ramat Gan, Israel. Patients were genetically diagnosed by a complimentary immune work-up. We identified 5 patients (3 males) from four different consanguineous families harboring three novel mutations in the complement components C6-C8. Genetic mutations were identified by whole exome sequencing. Clinical manifestations consisted of meningitis with or without meningococcemia. The immune work-up demonstrated nearly absent levels of CH50, compatible with a complement pathway defect. The mean diagnosis delay was 10.56 (0–30) years. Conclusion: Invasive meningococcal infections may be life-threatening and cause severe neurological sequela. Awareness of risk factors for primary complement deficiencies, even at the firs infectious episode, should facilitate prompt immune and genetic investigations, commencing diagnosis and proper treatment.