bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Occupational Accidents: A Data Mining Study
Authors: Dadfarma Vahideh , Soltanzadeh Ahmad , Ghiyasi Samira 
Published: September 2021

Introduction: Despite efforts exerted in various areas of the industry to reduce occupational accidents, the frequency of these accidents is reported to be catastrophically high. Therefore, this study was designed and conducted to analyze occupational accidents during a 3-year period.
Methods: The current study was a retrospective and descriptive-analytical study carried out in four regions of Tehran between 2019-2020. The data collection instrument consisted of 818 reports of the occupational accident recorded in the Department of Labor in Tehran. Feature selection (IBM SPSS Modeler software) and binominal multiple logistic regression analysis (IBM SPSS software) were utilized in this study.
Results: The means of age and experience of injured workers were found to be 34.55±11.55 and 14.12±9.87, respectively. The highest rate of occupational accidents belonged to construction workshops (52.4%), production (24.4 %) and other public and social services activities (11.1 %). Data mining and modeling of factors affecting these occupational accidents showed that the consequence of the accidents was affected by seven factors (p<0.05). The results showed that the work experience, type of activity, number of workers, accident time on the day, type of incidence and the causes of the accident remained in the final model and were significant with the consequence of the occupational accidents (p<0.05).
Conclusion: The results indicated that different parameters can affect the occurrence of occupational accidents. Additionally, the consequences of these occupational accidents can be influenced by different parameters and factors.
Exploring the Viewpoint of Oil Industry Employees about Factors Affecting the Success of Standard Operating Procedures
Authors: Shaban Iman , Farshad Ali asghar , Yarahmadi Rasoul , Mansourian Morteza , Kharghani Moghadam Seyedeh Melika , Abedi Kamaladdin , Ebrahimi Hossein 
Published: September 2021

Background: Different factors affect the success of standard operational procedures (SOPs). This study was conducted to explore the viewpoints of employees of Tehran Oil Refining Company about factors affecting the usability of SOPs.
Methods: This qualitative study was a conventional content analysis research conducted on the oil refining company employers 2020, using the semi-structured interviews. The data were analyzed by content analysis method using MAXQDA software.
Results: The results showed that the employees had a positive perception toward the standard operating procedures and most of them used these procedures to improve work performance and reduce accidents. Also, from the viewpoint of the employees, organizational factors (desirable organizational culture, continuous supervision and evaluation and assurance of accurate implementation of instructions, and continuous personnel training), individual factors (positive perception of the personnel about the organization goals, rules obedience of the personnel, positive experiences of personnel from the implementation of instructions in the past), and environmental factors (environmental dynamics and their related SOP dynamics, desirable but formal relationships of managers and supervisors with personnel as well as optimal and standard work schedule) had a positive effect on the applicability of these procedures.
Conclusion: The findings of this study showed that the employees, consider standard operating procedures of organizational, individual, and environmental factors effective in using standard operating instructions. Therefore, to increase the applicability of these procedures, the employees should consider their opinions.
AKUN INSTAGRAM SEKOLAH RELAWAN DAN PENGARUHNYA TERHADAP PEMBENTUKAN KEPEDULIAN SOSIAL DI KALANGAN GENERASI-Z
Authors: Prihantoro Edy , Haryanti Dwi Asih , Ohorella Noviawan Rasyid , Kusumaningtyas Susilowati Dyah 
Published: September 2021

Instagram @sekolahrelawan is an account that is a place for users to share and help others. This study aims to see the influence of the media on the Instagram account @sekolahrelawan Volunteers on the level of concern among Generation-Z. This research uses quantitative research with an explanatory approach. This research was conducted by sending online questionnaires to AKMRTV Jakarta students who are followers or have seen Instagram @sekolahrelawam content. Respondents in this study were 86 people and were determined based on simple random sampling. Meanwhile, to obtain data through a questionnaire or questionnaire. The results of this study indicate that the influence of Instagram @sekolahrelawan on the level of social care among generation z. Evidenced by the value of the regression coefficient in this study is Y = 39.261 + 0.618X. The constant number is 39,261 and the Instagram influence variable is 0.618. Meanwhile, t count 39.261 is bigger than t table 16.63, with a significance level of 0.000 smaller than α = 0.05. Based on the table "Model Summary", that the value of R = 0.618 and the coefficient of determination (Rsquare) is 0.464. This figure shows the understanding that the contribution of the @sekolah volunteer Instagram account attack variable to the Level of Social Care among Generation Z at AKMRTV Jakarta is 61.8%. The @Sekolahrelawan account has a positive influence on Generation Z social care. The information conveyed through this account provides a clear picture of social realities in society that require the care of all parties, especially Generation Z.
Effect of Flue Gas on Steam Chamber Expansion in Steamflooding
Authors: Lu Teng , Xu Zhengxiao , Ban Xiaochun , Peng Dongliang , Li Zhaomin 
Published: September 2021

Summary
The expansion of the steam chamber is very important for the recovery performance of steamflooding. In this paper, we discuss 1D and 2D sandpack experiments to performed analyze the effect of flue gas on steam chamber expansion and displacement efficiency in steamflooding. In addition, we examine the effect of flue gas acting on the steam condensation characteristics. The results show that within a certain range of injection rate, flue gas can significantly enlarge the swept volume and oil displacement efficiency of steam. However, when the flue gas injection rate is excessively high (the ratio of gas injection rate to steam injection rate exceeds 4), gas channels may form, resulting in a decline of oil recovery from steamflooding. The results of the 2D visualization experiments reveal that the swept volume of the steam chamber during steamflooding was small, and the remaining oil saturation in the reservoir was high, so the recovery was only 28%. The swept volume of the steam chamber for flue-gas-assisted steamflooding was obviously larger than that of steamflooding, and the recovery of flue-gas-assisted steamflooding in 2D experiments could reach 40.35%. The results of the steam condensation experiment indicate that flue gas could reduce the growth and coalescence rates of steam-condensed droplets on the cooling wall and increase the shedding period of the droplets. Macroscopically, flue gas could reduce the heat exchange rate between the steam and the reservoir and inhibit the rapid condensation and heat exchange of the steam near the injection well. As a result, flue gas could expand the steam chamber into the reservoir for heating and displacing oil.
A Randomized Double-Blind Cross-Over Trial to Study the Effects of Resistant Starch Prebiotic in Chronic Kidney Disease (ReSPECKD)
Authors: Shamloo Maryam , Mollard Rebecca , Wang Haizhou , Kingra Kulwant , Tangri Navdeep , MacKay Dylan 
Published: September 2021

Abstract
Background: Chronic kidney disease (CKD) is associated with a reduced quality of life and an increased risk of kidney failure, cardiovascular events, and all-cause mortality. Accumulation of nitrogen-based uremic toxins leads to worsening of symptoms in individuals with CKD. Many uremic toxins, such as indoxyl and p-cresol sulphate, are produced exclusively by the gut microbiome through the proteolytic digestion of aromatic amino acids. Strategies to reduce the production of these toxins by the gut microbiome in individuals with CKD may lessen symptom burden and delay the onset of dialysis. One such strategy is to change the overall metabolism of the gut microbiome so that less uremic toxins are produced. This can be accomplished by manipulating the energy source available to the microbiome. Fermentable carbohydrates which reach the gut microbiome, like resistant starch (RS), have been shown to inhibit or reduce bacterial amino acid metabolism. This study aims to investigate the the effects of resistant potato starch (RPS) as a prebiotic in individuals with CKD before the onset of dialysis. Methods: This is a double blind, randomized two-period crossover trial. 36 eligible participants will consent to follow a 26-week study regimen. Participants will receive 2 sachets per day containing either 15 grams of RPS (MSPrebiotic, resistant potato starch treatment) or 15 grams corn starch (Amioca TF, digestible starch control). Changes in blood uremic toxins will be investigated as the primary outcome. Secondary outcomes include the effect of RPS consumption on symptoms, quality of life and the abundance, diversity and functionality of the gut microbiome.Discussion: This pilot randomized trial will provide further insight into whether the consumption of RPS as a prebiotic will reduce uremic toxins and symptoms in individuals who have CKD. Trial registration: NCT04961164
n-Heptane Isomerization Activities of Pt Catalyst Supported On Micro/Mesoporous Composites
Authors: Ghaderi Z. , Peyrovi M. H. , Parsafard n. 
Published: September 2021

Abstract
Pt loaded on a series of MCM-48 and composites with HZSM-5, HY or TiO2 has been prepared and studied for n-heptane isomerization reaction at 200–350°C. The structural characterization, acid distribution and morphology of these catalysts were characterized by XRD, FT-IR, UV-Vis DRS, SEM, NH3-TPD, and nitrogen adsorption-desorption methods. These new catalysts have good ability for n-heptane isomerization. The ideal catalytic performance was observed on Pt/MCM48-HZSM5 catalyst.
Human Cytomegalovirus Induced Immune Regulation Is Correlated With Poor Prognosis in Colorectal Cancer Patients
Authors: Fang Yangyang , Wang Qiongdan , Huang Kaizhao , Zhang Mengyue , Pei Shunjie , Li Liyi , Peng Ying , Lan Linhua , Zheng Xiaoqun 
Published: September 2021

Abstract
Available evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progression of colorectal cancer (CRC). However, the correlation between HCMV infection and survival outcomes in CRC patients is unclear. Here, we constructed a flow algorithm to identify HCMV sequences based on the RNA-seq data of CRC patients derived from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The patients' clinical information matrix was used to calculate Euclidean distance to filter out suitable patients not infected with HCMV, combining with the patient's survival outcome to reveal how HCMV infection is involved in CRC progression.HCMV infection is widespread in CRC patients., The prevalence of HCMV infection is ranging from 10% to 36% in 4 independent CRC datasets with infection being concentrated in carcinoma tissue rather than in normal tissue. In addition, HCMV positive patients had a poor survival prognosis, with three of the HCMV genes associated with poor patient survival outcomes, UL82, UL42 and UL117. Most importantly, we suppose that the regulation of immune function by HCMV may be the key to the poor prognosis of CRC patients. We found that HCMV infection was associated with poor prognosis in CRC patients and identified three prognosis associated HCMV genes. The regulation of immune function caused by HCMV infection was the key factor while HCMV positive CRC patients mostly presented a state of immunosuppression. This may provide new ideas for personalized treatment of CRC patients, especially in immunotherapy.
Bioaccumulation and Toxicity Effects of Flubendiamide in Zebrafish (Danio Rerio)
Authors: Meng Zhiyuan , Wang Zhichao , Chen xiaojun , Song Yueyi , Teng Miaomiao , Fan Tianle , Zheng Yang , Cui Jiajia , Xu Wangjing 
Published: September 2021

Abstract
As a diamide insecticide, flubendiamide is widely used and has many adverse effects on environmental organisms. In this study, bioaccumulation and toxicity effects of flubendiamide in zebrafish (Danio rerio) were studied. Specifically, the results showed that the concentrations of flubendiamide increased in the early stage and achieved steady stages at 14 days and the bioconcentration factors (BCFs) of flubendiamide in zebrafish were 1.125 - 2.011. Furthermore, flubendiamide had no significant effects on the growth phenotypes of zebrafish. However, zebrafish hepatic somatic index (HSI) of zebrafish had changed significantly with exposure. Histopathological analysis showed that exposure to flubendiamide could cause structural damage to liver tissue of zebrafish. Further physiological and biochemical analysis showed that flubendiamide could significantly change the activity of CAT and the contents of MDA and GSH in liver of zebrafish. In particular, exposure to flubendiamide could also cause significant changes in the mRNA expression levels of cell apoptosis-related genes involving p53, puma, caspase-3, caspase-9, apaf-1 and bax in liver of zebrafish. In general, these results indicated that exposure to flubendiamide could induce liver damage by inducing oxidative stress and apoptosis in liver of zebrafish. The results of this study will help to further comprehensively evaluate the safety of flubendiamide to aquatic organisms.
Quercetin Improves the Apoptotic Index and Oxidative Stress in Post-Thaw Dog Sperm
Authors: Bang Seonggyu , Qamar Ahmad Yar , Tanga Bereket Molla , Fang Xun , Seong Gyeonghwan , Nabeel Abdelbagi Hamad Talha , Yu Il-Jeoung , Saadeldin Islam M. , Cho JongKi 
Published: September 2021

Abstract
This study was conducted to investigate if quercetin (QRN) may ameliorate apoptosis and oxidative stress in post-thaw dog sperm. Herein, we evaluated the post-thaw apoptosis and oxidative stress after treatment with QRN (control, 25, 50, and 100 µM) in freezing of dog semen. The oxidative stress index was significantly affected (p<0.05) between the various concentrations of QRN and the control (17.56 ± 1.02, 7.54 ± 0.48, 5.66 ±0.80, and 10.41 ± 0.69), respectively. The apoptosis index was 9.1 ± 1.34, 6.66 ± 0.58, 6.77 ± 0.66, and 5.38 ± 0.86 in the control, and 25, 50, and 100 µM QRN treatment groups, respectively (p< 0.05). The effects of ameliorated cryo-induced damage by QRN on post-thaw sperm quality were also observed through improved structural and functional tests. Sperm treated with 50 µM QRN showed significantly higher motility (51.8 ± 2.1% vs. 43.1 ± 1.4%, P < 0.05), survival rates (46.9 ± 0.7% vs. 43.9 ± 0.4%, P < 0.05), and mucus penetration than control group, respectively. Results demonstrate that supplementing freezing buffer with 50 µM QRN reduced oxidative damage and improved the quality of post-thaw dog sperm.
Construction of Full-Length Infectious Clones of Turnip Mosaic Virus Isolates Infecting Perilla Frutescens and Genetic Analysis of Recently Emerged Strains of Tumv in Korea
Authors: Song Zheng-Xing , Chu Su-Jeong , Seo Eun-Young , Hu Wen-Xing , Lim Yong Pyo , Park Tae-Seon , Park Ji-Soo , Hong Jin-Sung , Cho In-Sook , Hammond John , Lim Hyoun-Sub 
Published: September 2021

Abstract
Perilla is an annual herb with a unique aroma and taste and has been cultivated in Korea for hundreds of years. Owing to the highly edible and medicinal value of Perilla plants, it has been widely cultivated in many Asian and European countries. Recently, several viruses have been reported to cause diseases in Perilla in Korea, including turnip mosaic virus (TuMV) which is known as a brassica pathogen due to its significant damage to brassica crops. In this study, we determined the complete genome sequences of two new TuMV isolates originating from Perilla in Korea. Full-length infectious cDNA clones of these two isolates were constructed and their infectivity was tested by agroinfiltration on Nicotiana benthamiana and sap inoculation on Chinese cabbage and radish. In addition, we analyzed the phylogenetic relationship of six new Korean TuMV isolates and determined their respective affiliation with the four major groups. We also conducted recombination analysis for isolates recently occurring in Korean using RDP4 software, which provided new insight into the evolutionary relationships among Korean isolates of TuMV.
Disability and Self-care Living Strategies Among Adults Living With HIV During the COVID-19 Pandemic
Authors: O'Brien Kelly K , Bayoumi Ahmed M , Carusone Soo Chan , Davis Aileen M , Aubry Rachel , Avery Lisa , Solomon Patty , Erlandson Kristine M , Bergin Colm , Harding Richard , Brown Darren A , Vera Jaime H , Hanna Steven 
Published: September 2021

Abstract
BackgroundEvents associated with the COVID-19 pandemic, such as physical distancing, closure of community services, postponement of health appointments, and loss of employment can lead to social isolation, financial uncertainty, and interruption of antiretroviral adherence, resulting in additional health-related challenges (disability) experienced among adults living with chronic illness such as HIV. ‘Living strategies’ is a concept derived from the perspective of people living with HIV, defined as behaviors, attitudes and beliefs adopted by people living with HIV to help deal with disability associated with HIV and multi-morbidity. Our aim was to describe disability among adults living with HIV and self-care living strategies used during the COVID-19 pandemic. MethodsAdults living with HIV in Toronto, Ontario, Canada, including some with pre-pandemic HIV Disability Questionnaire (HDQ) data, completed a cross-sectional web-based survey between June-August 2020. The survey included the HDQ and questions about self-care living strategy use during the pandemic. We compared disability (HDQ) scores prior to versus during the pandemic using paired t-tests. We reported the proportion of participants who engaged in various living strategies at least ‘a few times a week’ or ‘everyday’ during the pandemic. ResultsOf the 63 respondents, 84% were men, median age 57 years, and 62% lived alone. During the pandemic the greatest disability severity was in the uncertainty (median 30; Interquartile range (IQR): 16, 43) and mental-emotional (25; IQR: 14, 41) domains. Among the 51 participants with pre-pandemic data, HDQ severity scores were significantly greater (worse) during the pandemic (vs prior) in all domains. Greatest change from prior to during the pandemic was in the mental-emotional domain for presence (17.7; p<0.001), severity (11.4; p<0.001), and episodic nature (9.3; p<0.05) of disability. Most participants (>60%) reported engaging a ‘few times a week’ or ‘everyday’ in self-care strategies associated with maintaining sense of control and adopting positive attitudes and beliefs. ConclusionsPeople living with HIV reported high levels of uncertainty and mental-emotional health challenges during the pandemic. Disability increased across all HDQ dimensions, with the greatest worsening in the mental-emotional health domain. Results provide an understanding of disability and self-care strategy use during the COVID-19 pandemic.
LncRNA SNHG8 Promotes Liver Cancer Proliferation and Metastasis by Sponging miR-542-3p and miR-4701-5p
Authors: Tong He , He Shuang , Li Kexin , Sa qirile , Zhang Kefan , Jin Haowei , Shi Jing , Cheng Yipeng , Wang Li , wang changshan , Liu Pengxia 
Published: September 2021

Abstract
Growing evidence suggests that long non-coding RNAs (lncRNAs) are associated with carcinogenesis and could function as competing endogenous RNAs (ceRNAs) to regulate microRNAs (miRNAs). LncRNA small nucleolar RNA host gene 8 (LncRNA SNHG8) is up-regulated in various cancers and positively associated with poor prognosis of these cancers. However, the molecular mechanisms by which lncRNA SNHG8 contributes to hepatocellular carcinoma (HCC) still remains unclear. In the present study, we reported that lncRNA SNHG8 was abnormally up-regulated in liver cancer tissues and HCC cell lines. Moreover, knockdown of lncRNA SNHG8 significantly attenuated the proliferation, migration, invasion process of HCC cell line HepG2 in vitro. Mechanistically, we first reported that suppression of lncRNA SNHG8 evidently enhanced miR-542-3p and miR-4701-5p expression and decreased TET3 expression at posttranscriptional level. Furthermore, lncRNA SNHG8 upregulated TET3 expression by sponging miR-542-3p and miR-4701-5p by competing binding. Taken together, our results confirmed the oncogene role of lncRNA SNHG8 and discovered the underlying mechanism that lncRNA SNHG8 upregulated TET3 through the sponging or decaying of miR-542-3p and miR-4701-5p in human hepatocellular carcinoma, suggesting that lncRNA SNHG8 may serve as a potential diagnostic marker and therapeutic target for patients with hepatocellular carcinoma.
Silica Nanoparticles With Encapsulated DNA (SPED) to Trace the Spread of Pathogens in Healthcare
Authors: Ullrich Cinzia , Luescher Anne M , Koch Julian , Grass Robert N , Sax Hugo 
Published: September 2021

Abstract
Background: To establish effective infection control protocols, understanding pathogen transmission pathways is essential. Non-infectious surrogate tracers may safely explore these pathways and challenge pre-existing assumptions. We used silica nanoparticles with encapsulated DNA (SPED) for the first time in a real-life hospital setting to investigate potential transmission routes of vancomycin-resistant enterococci in the context of a prolonged outbreak.Methods: The two study experiments took place in the 900-bed University Hospital Zurich, Switzerland. A three-run ‘Patient experiment’ investigated pathogen transmission via toilet seats in a two-patient room with shared bathroom. First, various predetermined body and fomite sites in a two-bed patient room were probed at baseline. Then, after the first patient was contaminated with SPED at the subgluteal region, both patients sequentially performed a toilet routine. All sites were consequently swabbed again for SPED contamination. Eight hours later, further spread was tested at predefined sites in the patient room and throughout the ward. A two-run ‘Mobile device experiment’ explored the potential transmission by mobile phones and stethoscopes in a quasi-realistic setting. All SPED contamination statuses and levels were determined by real-time qPCR.Results: Over all three runs, the ‘Patient experiment’ yielded SPED in 59 of 73 (80.8 %) predefined body and environmental sites. Specifically, positivity rates were 100 % on subgluteal skin, toilet seats, tap handles, and entertainment devices, the initially contaminated patients’ hands; 83.3 % on patient phones and bed controls; 80 % on intravenous pumps; 75 % on toilet flush plates and door handles, and 0 % on the initially not contaminated patients’ hands. SPED spread as far as doctor’s keyboards (66.6 %), staff mobile phones (33.3 %) and nurses’ keyboards (33.3 %) after eight hours. The ‘Mobile device experiment’ resulted in 16 of 22 (72.7 %) positive follow-up samples, and transmission to the second patient occurred in one of the two runs. Conclusions: For the first time SPED were used to investigate potential transmission pathways in a real hospital setting. The results suggest that, in the absence of targeted cleaning, toilet seats and mobile devices may result in widespread transmission of pathogens departing from one contaminated patient skin region.