bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laterality hotspots in the striatum
Authors: Korponay Cole , Stein Elliot A , Ross Thomas J 
Published: October 2021

Abstract
Striatal loci are connected to both the ipsilateral and contralateral frontal cortex. Normative quantitation of the dissimilarity between striatal loci’s hemispheric connection profiles and its spatial variance across the striatum, and assessment of how interindividual differences relate to function, stands to further the understanding of the role of corticostriatal circuits in lateralized functions and the role of abnormal corticostriatal laterality in neurodevelopmental and other neuropsychiatric disorders. A resting-state functional connectivity fingerprinting approach (n = 261) identified “laterality hotspots”—loci whose profiles of connectivity with ipsilateral and contralateral frontal cortex were disproportionately dissimilar—in the right rostral ventral putamen, left rostral central caudate, and bilateral caudal ventral caudate. Findings were replicated in an independent sample and were robust to both preprocessing choices and the choice of cortical atlas used for parcellation definitions. Across subjects, greater rightward connectional laterality at the right ventral putamen hotspot and greater leftward connectional laterality at the left rostral caudate hotspot were associated with higher performance on tasks engaging lateralized functions (i.e., response inhibition and language, respectively). In sum, we find robust and reproducible evidence for striatal loci with disproportionately lateralized connectivity profiles where interindividual differences in laterality magnitude are associated with behavioral capacities on lateralized functions.
Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging
Authors: Gianella Sara , Rawlings Stephen A , Dobrowolski Curtis , Nakazawa Masato , Chaillon Antoine , Strain Matthew , Layman Laura , Caballero Gemma , Scully Eileen , Scott Brianna , Pacis Caitleen , Weber Kathleen M , Landay Alan , Anderson Christy , Karn Jonathan 
Published: October 2021

Abstract

Background
Sex differences in human immunodeficiency virus (HIV) reservoir dynamics remain underexplored.

Methods
Longitudinal samples from virally suppressed midlife women (n = 59, median age 45 years) and age-matched men (n = 31) were analyzed retrospectively. At each time point, we measured sex hormones (by means of enzyme-linked immunosorbent assay) and cellular HIV DNA and RNA (by means of digital droplet polymerase chain reaction). Number of inducible HIV RNA+ cells, which provides an upper estimate of the replication-competent reservoir, was quantified longitudinally in a different subset of 14 women, across well-defined reproductive stages. Mixed-effects models included normalized reservoir outcomes and sex, time since antiretroviral therapy (ART) initiation, and the sex-by-time interaction as predictors.

Results
At ART initiation, women and men had median (interquartile range [IQR]) CD4+ T-cell counts of 204/μL (83–306/μL) versus 238/μL (120–284/μL), respectively; median ages of 45 (42–48) versus 47 (43–51) years; and median follow-up times of 79.2/μL (60.5–121.1/μL) versus 66.2/μL (43.2–80.6/μL) months. We observed a significant decline of total HIV DNA over time in both men and women (P &lt; .01). However, the rates of change differed significantly between the sexes (P &lt; .01), with women having a significantly slower rate of decline than men, more pronounced with age. By contrast, the levels of inducible HIV RNA increased incrementally over time in women during reproductive aging (P &lt; .01).

Conclusions
In contrast to men, in whom the HIV reservoir steadily declines with aging, the HIV reservoir in women is more dynamic. Total HIV DNA (including intact and defective genomes) declines more slowly in women than in men, while the inducible HIV RNA+ reservoir, which is highly enriched in replication-competent virus, increases in women after menopause.
Inflammatory Bowel Disease-related Behaviours [IBD-Bx] Questionnaire: Development, Validation and Prospective Associations with Fatigue
Authors: Walentynowicz Marta , van de Pavert Iris , Fierens Liselotte , Coenen Sofie , Vlaeyen Johan W S , von Leupoldt Andreas , Van Oudenhove Lukas , Vermeire Séverine , Van Assche Gert , Ferrante Marc , Van Diest Ilse 
Published: October 2021

AbstractBackground and AimsDisease-related behaviours that may maintain or worsen symptom burden remain largely unexplored in inflammatory bowel disease [IBD]. In this study, we developed and validated an instrument assessing IBD-related, modifiable behaviours and explored which behaviours prospectively correlate with fatigue, a debilitating and common symptom in IBD.MethodsInitially, 72 items reflecting IBD-related behaviours were generated based on literature review and input from clinicians and people diagnosed with IBD. During wave 1, 495 IBD patients rated to what extent each behaviour was applicable to them. Additionally, disease activity, fatigue, IBD-related concerns and psychological variables were assessed. During a follow-up visit 4–12 weeks later [wave 2], a random selection of 92 patients from wave 1 completed the measures assessing the IBD-related behaviours, disease activity and fatigue once more.ResultsA principal component analysis with oblique rotation revealed seven components in the 72 IBD behaviours, which could be interpreted as: [1] Avoiding food and activities, [2] Access to toilets, [3] Avoidance of sex, [4] Cognitive avoidance, [5] Not sharing with others, [6] Alternative treatments and [7] Disease management. Each component was reduced to three to five representative items, resulting in a final, 25-item IBD-Bx questionnaire showing good concurrent validity [alphas &gt; 0.63] and reliability. Almost all components were cross-sectionally related to levels of fatigue. Avoiding food and activities and Access to toilets significantly predicted fatigue at wave 2 when controlling for baseline fatigue.ConclusionsThe IBD-Bx is a valid and reliable questionnaire of IBD-related behaviours, some of which predict future fatigue burden.
Effects of Diet and Temperature on the Life History of the Redlegged Ham Beetle (Coleoptera: Cleridae)
Authors: Hasan Md Mahbub , Aikins Michael J , Mahroof Rizana M , Phillips Thomas W 
Published: October 2021

Abstract
We investigated the effects of various foods and different rearing temperatures on the survival and development of the redlegged ham beetle Necrobia rufipes (De Geer) (Coleoptera: Cleridae), a serious pest of dry-cured hams. The diets tested were dried pet food, finely shredded copra, shredded cheese, dry-cured ham, ground fish meal, and mature larvae of Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). As indicated by the growth index and k-values, N. rufipes populations grew fastest on the pet food and slowest on the copra. On the other hand, N. rufipes fed both ham and T. castaneum larvae produced significantly heavier larvae. The adult beetles lived significantly longer on cheese compared to other foods. Studies conducted to determine the developmental rates of N. rufipes fed pet food at temperatures of 22, 25, 28, and 31°C showed that the total developmental time and longevity of N. rufipes significantly varied at different temperatures tested. The shortest developmental time (93.32 d) was observed at 28°C. Oviposition rate was highest for females reared at 25°C while lowest at 22°C. Based on the development, reproduction, and thermal requirements, the most suitable temperature for N. rufipes was between 28 and 31°C. The results also revealed that larval cannibalism prevailed among adult beetles.
Sexual and Gender Minority (SGM) Research Meets Household Panel Surveys: Research Potentials of the German Socio-Economic Panel and Its Boost Sample of SGM Households
Authors: Fischer Mirjam M , Kroh Martin , De Vries Lisa , Kasprowski David , Kühne Simon , Richter David , Zindel Zaza 
Published: October 2021

Abstract
There are numerous challenges to studying structural inequality in sexual and gender minority (SGM) populations, from the difficulty of obtaining a representative sample to issues comparing data across populations. This data brief illustrates how the largest household panel survey in Germany, the German Socio-Economic Panel (SOEP), and its recent nationwide boost sample of SGM households, Sample Q, have addressed these challenges. We discuss the case of the SOEP and its boost sample to illustrate the untapped potentials that lie in other national household panels for research into the lived experiences of SGM people, couples, and families. Based on the SOEP example, we show the potential for cross-sectional comparative, retrospective, and longitudinal life course research using the detailed information on the extended families (parents, children, siblings, and relatives) of SGM respondents in household panel surveys.
International cohort study on the effectiveness of dronedarone and other antiarrhythmic drugs for atrial fibrillation in real-world practice (EFFECT-AF)
Authors: Khachatryan Artak , Merino Jose L , de Abajo Francisco Jose , Botto Giovanni L , Kirchhof Paulus , Breithardt Guenter , Stambler Bruce , Abenhaim Lucien , Grimaldi-Bensouda Lamiae 
Published: October 2021

Abstract

Aims
To evaluate the effectiveness and safety of dronedarone compared with other commonly used antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrences.

Methods and results
An international observational cohort study in Germany, Spain, Italy, and the USA enrolling patients with AF receiving AAD therapy. Patients with New York Heart Association (NYHA) Class IV heart failure were excluded. Participants were followed for up to 18 months, regardless of discontinuation or subsequent AAD switches. Atrial fibrillation recurrence was captured by hospitalization, emergency room visit, or electrocardiogram-based documentation of AF. Confounding bias was controlled for in the analysis of AF recurrence using multivariate models of 19 variables for adjustment. A total of 1009 participants [mean age 67.2 (10.8) years, male to female ratio 1.3] were recruited from 170 centres, 693 (69%) of which were from across Europe and the remaining 316 (31%) from the USA. At the time of enrolment, participants were taking dronedarone (51%) or other AADs (49%) [flecainide or propafenone (42%), sotalol (11%), and amiodarone (47%)]. No significant differences in the risk of first confirmed AF recurrence with dronedarone vs. other AADs [crude hazard ratio (HR) 1.10 (95% confidence interval 0.85–1.42); adjusted HR 1.16 (0.87–1.55)] were found, irrespective of whether univariate or multivariate models were used. Reported safety events were in accordance with the known safety profile of dronedarone.

Conclusion
In this population of patients from either Europe or the USA receiving dronedarone or another AAD, the effectiveness of dronedarone was comparable to that observed for other AADs in preventing first AF recurrence.
The Quality in Nutrition Care (QUINCE) model: development of a model based on Australian healthcare consumer perspectives
Authors: Kirkegaard Amy , Ball Lauren , Mitchell Lana , Williams Lauren T 
Published: October 2021

Abstract

Background
Primary healthcare is the ideal setting to address diet-related disease through delivery of nutrition services. However, quality nutrition care has not previously been defined from the healthcare consumer perspective.

Objectives
To explore, and develop a theoretical model of, healthcare consumer expectations of quality nutrition care in the primary healthcare setting.

Methods
A qualitative study design collected data describing healthcare consumer expectations of nutrition care. Consumers were recruited through social media and research networks, screened, and invited to participate in a semi-structured telephone interview. Interviews explored experiences and views of nutrition care. Interviews were thematically analysed, and informed development of a model using an iterative process.

Results
Twenty-three healthcare consumers participated in an interview. Five themes were identified. The Quality in Nutrition Care consumer model developed from these themes comprised 5 interconnected components, these being: (i) quality nutrition care occurs within an integrated societal system; (ii) quality nutrition care is available, accessible, and affordable; (iii) quality nutrition care is up-to-date and evidence based; (iv) quality nutrition care is underpinned by positive relationships; and (v) quality nutrition care is personalized to consumer needs.

Conclusions
The consumer-derived model of quality nutrition care can be used by providers to inform activities that enhance primary healthcare practice, outcomes, and impact. The model has important implications for primary healthcare system reform and policy. Future research should explore the provision of dietetic services in primary care, with specific focus on factors that influence quality care, and investigate how quality is monitored and improved.
CeLINC, a fluorescence-based protein–protein interaction assay inCaenorhabditis elegans
Authors: Kroll Jason R. , Remmelzwaal Sanne , Boxem Mike 
Published: October 2021

AbstractInteractions among proteins are fundamental for life and determining whether two particular proteins physically interact can be essential for fully understanding a protein’s function. We present Caenorhabditis elegans light-induced coclustering (CeLINC), an optical binary protein–protein interaction assay to determine whether two proteins interact in vivo. Based on CRY2/CIB1 light-dependent oligomerization, CeLINC can rapidly and unambiguously identify protein–protein interactions between pairs of fluorescently tagged proteins. A fluorescently tagged bait protein is captured using a nanobody directed against the fluorescent protein (GFP or mCherry) and brought into artificial clusters within the cell. Colocalization of a fluorescently tagged prey protein in the cluster indicates a protein interaction. We tested the system with an array of positive and negative reference protein pairs. Assay performance was extremely robust with no false positives detected in the negative reference pairs. We then used the system to test for interactions among apical and basolateral polarity regulators. We confirmed interactions seen between PAR-6, PKC-3, and PAR-3, but observed no physical interactions among the basolateral Scribble module proteins LET-413, DLG-1, and LGL-1. We have generated a plasmid toolkit that allows use of custom promoters or CRY2 variants to promote flexibility of the system. The CeLINC assay is a powerful and rapid technique that can be widely applied in C. elegans due to the universal plasmids that can be used with existing fluorescently tagged strains without need for additional cloning or genetic modification of the genome.
HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model
Authors: Alexander Courtney Carroll , Munkáscy Erin , Tillmon Haven , Fraker Tamara , Scheirer Jessica , Holstein Deborah , Lozano Damian , Khan Maruf , Gidalevitz Tali , Lechleiter James D , Fisher Alfred L , Zare Habil , Rodriguez Karl A 
Published: October 2021

AbstractTo explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in rodents and Hsp27 in humans) in longevity, we created a Caenorhabiditis elegans model with a high level of ubiquitous expression of the naked mole-rat HspB1 protein. The worms showed increased life span under multiple conditions and also increased resistance to heat stress. RNAi experiments suggest that HspB1-induced life extension is dependent on the transcription factors skn-1 (Nrf2) and hsf-1 (Hsf1). RNAseq from HspB1 worms showed an enrichment in several skn-1 target genes, including collagen proteins and lysosomal genes. Expression of HspB1 also improved functional outcomes regulated by SKN-1, specifically oxidative stress resistance and pharyngeal integrity. This work is the first to link a small heat shock protein with collagen function, suggesting a novel role for HspB1 as a hub between canonical heat response signaling and SKN-1 transcription.
A unified wavefield-partitioning approach for distributed acoustic sensing
Authors: Atterholt James , Zhan Zhongwen , Shen Zhichao , Li Zefeng 
Published: October 2021

SUMMARY
While distributed acoustic sensing (DAS) has been demonstrated to have great potential in seismology, DAS data often have much higher levels of stochastic and coherent noise (e.g. instrument noise, traffic vibrations) than data collected by traditional seismometers. The linearly, densely spaced nature of DAS arrays presents a suite of opportunities for more innovative processing techniques that can be used to address this issue. One way to take advantage of DAS’s array architecture is through the use of curvelets. Curvelets have a non-uniform scaling property that makes them an excellent tool for representing images with discontinuities along piecewise, twice continuously differentiable curves. This anisotropic scaling property makes curvelets an ideal processing tool for DAS data, for which the measured wavefield can be represented as an image composed of curved features. Here, we use the curvelet frame as a tool for the manipulation of DAS signal and demonstrate how this manipulation can improve our ability to identify important features in DAS data sets. We use the curvelet representation to partition the measured wavefield using DAS data collected near Ridgecrest, CA, following the 2019 Mw7.1 Ridgecrest earthquake. Here, we isolate the earthquake-induced wavefield from coherent and stochastic noise using the curvelet frame in an effort to improve the results of template matching of the Ridgecrest aftershock sequence. We show that our wavefield-partitioning technique facilitates the identification of over 30 per cent more aftershocks and greatly reduces the magnitude of diurnal depressions in the aftershock catalogue due to cultural noise.
Cellular and metabolic effects of renin-angiotensin system blockade on glycogen storage disease type I nephropathy
Authors: Monteillet Laure , Labrune Philippe , Hochuli Michel , Do Cao Jeremy , Tortereau Antonin , Miliano Alexane Cannella , Ardon-Zitoun Carine , Duchampt Adeline , Silva Marine , Verzieux Vincent , Mithieux Gilles , Rajas Fabienne 
Published: October 2021

Abstract
Glycogen Storage Disease Type I (GSDI) is an inherited disease caused by glucose-6 phosphatase (G6Pase) deficiency, leading to a loss of endogenous glucose production and severe hypoglycemia. Moreover, most GSDI patients develop a chronic kidney disease (CKD) due to lipid accumulation in the kidney. Similar to diabetic CKD, activation of renin-angiotensin system (RAS) promotes renal fibrosis in GSDI. Here, we investigated the physiological and molecular effects of RAS blockers in GSDI patients and mice. A retrospective analysis of renal function was performed in 21 GSDI patients treated with RAS blockers. Cellular and metabolic impacts of RAS blockade were analyzed in K.G6pc−/− mice characterized by G6pc1 deletion in kidneys. GSDI patients started RAS blocker treatment at a median age of 21 years and long-term treatment reduced the progression of CKD in about 50% of patients. However, CKD progressed to kidney failure in 20% of treated patients, requiring renal transplantation. In K.G6pc−/− mice, CKD was associated with an impairment of autophagy and ER stress. RAS blockade resulted in a rescue of autophagy and decreased ER stress, concomitantly with decreased fibrosis and improved renal function, but without impact on glycogen and lipid contents. In conclusion, these data confirm the partial beneficial effect of RAS blockers in the prevention of CKD in GSDI. Mechanistically, we show that these effects are linked to a reduction of cell stress, without affecting metabolism.
Correlation of ventricular septal defect height and outcomes after complete atrioventricular septal defect repair
Authors: Fong Laura S , Youssef David , Ayer Julian , Nicholson Ian A , Winlaw David S , Orr Yishay 
Published: October 2021

Abstract

OBJECTIVES
There are limited data available on the height of the ventricular component of the septal deficiency (VSD) in patients undergoing complete atrioventricular septal defect (CAVSD) repair. VSD height may influence optimal choice of repair strategy with potential consequences for long-term outcomes. We aimed to measure VSD height using 2-dimensional echocardiography and review its association with postoperative outcomes.

METHODS
We retrospectively reviewed the preoperative echocardiograms of 45 consecutive patients who underwent CAVSD repair between May 2010 and December 2015 at a single centre. VSD height and left ventricular length on the four-chamber view were measured. Demographic details and early and late outcomes including reoperation and long-term survival were studied.

RESULTS
Twenty patients underwent modified single-patch repair and 25 patients underwent double-patch repair of CAVSD. VSD height in the modified single-patch group ranged from 4.2 to 11.7 mm and in the double-patch group ranged from 5.1 to 14.9 mm. Nine patients had a deep ‘scoop’ with a VSD height of &gt;10 mm, (7 double patch, 2 modified single patch). VSD height did not correlate with a specific Rastelli classification. There was no significant difference in the VSD height (P = 0.51) or the VSD height-to-left ventricular length ratio (P = 0.43) between the 2 repair groups. There was no 30-day mortality. Eight patients required reoperation; however, VSD height was not a significant predictor of reoperation (hazard ratio 0.95, 95% confidence interval 0.69–1.33; P = 0.08).

CONCLUSIONS
There was no correlation between VSD height and risk of reoperation after CAVSD repair. A deep ventricular scoop is uncommon in CAVSD patients.
Nicotine Administration Normalizes Behavioral and Neurophysiological Perturbations in the MAM Rodent Model of Schizophrenia
Authors: Weeks Jillian J , Grace Anthony A , Sved Alan F 
Published: October 2021

Abstract

Background
The present study utilized the methylazoxymethanol (MAM) neurodevelopmental rodent model of schizophrenia (SCZ) to evaluate the hypothesis that individuals with SCZ smoke in an attempt to “self-medicate” their symptoms through nicotine (NIC) intake.

Methods
To explore this question, we examined the effects of acute and chronic administration of NIC in 2 established behavioral tests known to be disrupted in the MAM model: prepulse inhibition of startle and novel object recognition. Additionally, we assessed the effects of acute and chronic NIC on 2 indices of the pathophysiology of SCZ modeled by MAM, elevated dopamine neuron population activity in the ventral tegmental area and neuronal activity in the ventral hippocampus, using in vivo electrophysiological recordings.

Results
Our findings demonstrated that both acute and chronic administration of NIC significantly improved deficits in prepulse inhibition of startle and novel object recognition among MAM rats and normalized elevated ventral tegmental area and ventral hippocampal neuronal activity in these animals.

Conclusion
Together, these findings of NIC-induced improvement of deficits lend support for a “self-medication” hypothesis behind increased cigarette smoking in SCZ and illustrate the potential utility of nicotinic modulation in future pharmacotherapies for certain SCZ symptoms.
Convergence, error analysis and longtime behavior of the scalar auxiliary variable method for the nonlinear Schrödinger equation
Authors: Poulain Alexandre , Schratz Katharina 
Published: October 2021

AbstractWe carry out the convergence analysis of the scalar auxiliary variable (SAV) method applied to the nonlinear Schrödinger equation, which preserves a modified Hamiltonian on the discrete level. We derive a weak and strong convergence result, establish second-order global error bounds and present longtime error estimates on the modified Hamiltonian. In addition, we illustrate the favorable energy conservation of the SAV method compared to classical splitting schemes in certain applications.