bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic implication of elevated cardiac troponin I in patients visiting emergency department without diagnosis of coronary artery disease
Authors: Song Minseok , Kim Taerim , Kang Eun-Jin , Park Jong Eun , Park Soo Hyun , Cha Won Cul , Yoon Hee , Hwang Sung Yeon , Shin Tae Gun , Sim Min Seob , Jo IkJoon , Park Hyung-Doo , Choi Jin-Ho 
Published: January 2021

Abstract

Objectives
Elevated cardiac troponin is not uncommon in patients visiting emergency department (ED) even without coronary artery disease, but its prognostic implication is not well understood in such patients.

Methods
In this retrospective single-center registry, we investigated clinical outcome of patients visiting ED without documented coronary artery disease. Patients were categorized according to the maximal value of Siemens ADVIA Centaur TnI-Ultra assay (TnI) within 24 h after visit. Primary endpoint was 180-day all-cause death that included cardiac and non-cardiac death.

Results
A total of 35,205 patients with median age 61 years and male gender 54.7% were included. Below the lowest level of detection (LOD) (≤0.006 ng/mL), between LOD and assay-specific <99th percentile (0.007–0.039 ng/mL), below median of ≥99th percentile (0.040–0.149 ng/mL), and above median of ≥99th percentile (≥0.150 ng/mL) TnI were found in 18,502 (52.6%), 11,338 (32.2%), 3,029 (8.6%), and 2,336 (6.6%) patients. In the 180-day follow-up period, 4,341 (12.3%) all-cause death including 694 (2.0%) cardiovascular death and 3,647 (10.4%) non-cardiovascular death developed. The risks of all-cause, cardiovascular, and non-cardiovascular death increased across higher TnI strata (hazard ratio [HR]=1.3 to 2.4; 2.0 to 9.3; 1.3 to 1.7; p<0.001, all). Analyses of multivariate models showed consistent results.

Conclusions
In patients visiting ED, elevated TnI was associated with higher risk of 180-day cardiovascular and non-cardiovascular death. Patients with elevated TnI may need additional evaluation or careful follow-up even without primary diagnosis of coronary artery disease.
Performance of digital morphology analyzer Vision Pro on white blood cell differentials
Authors: Yoon Sumi , Hur Mina , Park Mikyoung , Kim Hanah , Kim Seung Wan , Lee Tae-Hwan , Nam Minjeong , Moon Hee-Won , Yun Yeo-Min 
Published: January 2021

Abstract

Objectives
Vision Pro (West Medica, Perchtoldsdorf, Austria) is a recently developed digital morphology analyzer. We evaluated the performance of Vision Pro on white blood cell (WBC) differentials.

Methods
In a total of 200 peripheral blood smear samples (100 normal and 100 abnormal samples), WBC preclassification and reclassification by Vision Pro were evaluated and compared with manual WBC count, according to the Clinical and Laboratory Standards Institute guidelines (H20-A2).

Results
The overall sensitivity was high for normal WBCs and nRBCs (80.1–98.0%). The overall specificity and overall efficiency were high for all cell classes (98.1–100.0% and 97.7–99.9%, respectively). The absolute values of mean differences between Vision Pro and manual count ranged from 0.01 to 1.31. In leukopenic samples, those values ranged from 0.09 to 2.01. For normal WBCs, Vision Pro preclassification and manual count showed moderate or high correlations (r=0.52–0.88) except for basophils (r=0.34); after reclassification, the correlation between Vision Pro and manual count was improved (r=0.36–0.90).

Conclusions
This is the first study that evaluated the performance of Vision Pro on WBC differentials. Vision Pro showed reliable analytical performance on WBC differentials with improvement after reclassification. Vision Pro could help improve laboratory workflow.
Resilience in Pandemic Time
Authors: Brett Christopher 
Published: January 2021

Abstract
Last time I wrote to you, we were finishing 2019, IUPAC’s centenary celebrations and the International Year of the Periodic Table of the Chemical Elements (IYPT). Since then, our world and how we related to it has changed dramatically. One year ago, we could not have imagined today’s reality. We are dealing with the consequences of a virus we knew little about and for which vaccines are starting to become available only now. The fact that the time for the development of vaccines has been shortened from several years to less than one year, is in itself the result of a huge scientific achievement; it involves interdisciplinary collaborations from microbiology to medicine, but also crucially underpinning chemistry. The pandemic has meant that our daily habits have changed, that we cannot travel or only with heavy restrictions, and that now we mostly meet on-line.
Challenges for Evaluation of the Safety of Engineered Nanomaterials
Authors: Johnston Linda J. , Gonzalez-Rojano Norma , Wilkinson Kevin J. , Xing Baoshan 
Published: January 2021

Abstract
Nanotechnology has developed rapidly in the last two decades with significant effort focused on the development of nano-enabled materials with new or improved properties that offer solutions for current world challenges. The commercialization of products containing engineered nanomaterials (ENM) has progressed much more rapidly than the development of practical approaches to ensure their safe and sustainable use. The lack of adequate detection and characterization techniques and reproducible and validated methods for toxicological studies have been identified as major limitations. The rapid development of ENM of increasing complexity and diversity and concerns over the adequacy of existing regulations also contribute to safety concerns with these materials. The full potential of nanotechnology can only be realized when feasible, cost-effective strategies to ensure a safe-by-design approach, effective risk assessment approaches and appropriate regulatory guidelines are in place.
Identification of novel cardiovascular disease associated metabolites using untargeted metabolomics
Authors: Tabrez Shams , Shait Mohammed Mohammed Razeeth , Jabir Nasimudeen R. , Khan Mohammad Imran 
Published: January 2021

Abstract
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality around the world. Early diagnosis of CVD could provide the opportunity for sensible management and better clinical outcome along with the prevention of further progression of the disease. In the current study, we used an untargeted metabolomic approach to identify possible metabolite(s) that associate well with the CVD and could serve either as therapeutic target or disease-associated metabolite. We identified 26 rationally adjusted unique metabolites that were differentially present in the serum of CVD patients compared with healthy individuals, among them 15 were found to be statistically significant. Out of these metabolites, we identified some novel metabolites like UDP-l-rhamnose and N1-acetylspermidine that have not been reported to be linked with CVD directly. Further, we also found that some metabolites like ethanolamide, solanidine, dimethylarginine, N-acetyl-l-tyrosine, can act as a discriminator of CVD. Metabolites integrating pathway enrichment analysis showed enrichment of various important metabolic pathways like histidine metabolism, methyl histidine metabolism, carnitine synthesis, along with arginine and proline metabolism in CVD patients. Our study provides a great opportunity to understand the pathophysiological role and impact of the identified unique metabolites and can be extrapolated as specific CVD specific metabolites.
Informationswissenschaft für Wissensmanager
Authors: Heisig Peter 
Published: January 2021

Zusammenfassung
Die Informationswissenschaften und das Wissensmanagement weisen zahlreiche Gemeinsamkeiten auf und Anknüpfungspunkte für gemeinsamen Forschungen. Praktiker des Wissensmanagements sollten die Forschungsergebnisse der Schwesterdisziplin eingehender studieren, um für Ihre Organisationspraxis relevante Ergebnisse berücksichtigen zu können. Es ist zu wünschen, dass durch einen gemeinsamen Forschungsdialog potenzielle Synergien für Forschung und Praxis zukünftig erschlossen werden.
Decentralized and parallel primal and dual accelerated methods for stochastic convex programming problems
Authors: Dvinskikh Darina , Gasnikov Alexander 
Published: January 2021

Abstract
We introduce primal and dual stochastic gradient oracle methods for decentralized convex optimization problems.
Both for primal and dual oracles, the proposed methods are optimal in terms of the number of communication steps.
However, for all classes of the objective, the optimality in terms of the number of oracle calls per node takes place only up to a logarithmic factor and the notion of smoothness.
By using mini-batching technique, we show that the proposed methods with stochastic oracle can be additionally parallelized at each node.
The considered algorithms can be applied to many data science problems and inverse problems.
Neonatal lupus erythematosus – practical guidelines
Authors: Derdulska Julia Marta , Rudnicka Lidia , Szykut-Badaczewska Agata , Mehrholz Dorota , Nowicki Roman J. , Barańska-Rybak Wioletta , Wilkowska Aleksandra 
Published: January 2021

Abstract

Background
Neonatal lupus erythematosus is an autoimmune disease acquired during fetal life as a result of transplacental passage of maternal anti-Sjögren’s-syndrome-related antigen A (anti-SSA/Ro), anti-Sjögren’s-syndrome-related antigen B (anti-SSB/La) or anti-U1 ribonucleoprotein (anti-U1-RNP) antinuclear autoantibodies.

Contents
Clinical manifestations include skin lesions, congenital heart block, hepatobiliary involvement and cytopenias. Most of the disorders disappear spontaneously after clearance of maternal antibodies. Cardiac symptoms, however, are not self-resolving and often pacemaker implantation is required. Diagnosis is based on clinical presentation and the presence of typical antibodies in the mother’s or infant’s serum.

Outlook
Neonatal lupus erythematosus may develop in children born to anti-SSA/Ro or anti-SSB/La women with various systemic connective tissue diseases. However, in half of the cases, the mother is asymptomatic, which may delay the diagnosis and have negative impact on the child’s prognosis. Testing for antinuclear antibodies should be considered in every pregnant woman since early treatment with hydroxychloroquine or intravenous immunoglobulin (IVIG) has proven to be effective in preventing congenital heart block.
Investigating peculiarities of piezoelectric detection methods for acoustic plate waves in material characterisation applications
Authors: Claes Leander , Schmiegel Hanna , Grünsteidl Clemens , Johannesmann Sarah , Webersen Manuel , Henning Bernd 
Published: January 2021

Abstract
Acoustic waves in plates have proven a viable tool for testing and material characterisation purposes. There are a multitude of options for excitation and detection of theses waves, such as optical and piezoelectric systems. While optical systems, with thermoelastic excitation and interferometric detection, have the benefit of being contactless, they usually require rather complex and expensive experimental setups. Piezoelectric systems are more easily realised but require direct contact with the specimen and usually have a limited bandwidth, especially in case of piezoelectric excitation. In this work, the authors compare the properties of piezoelectric and optical detection methods for broad-band acoustic signals. The shape (e. g. the displacement) of a propagating plate wave is given by its frequency and wave number, allowing to investigate correlations between mode shapes and received signal strengths. This is aided by evaluations in normalised frequency and wavenumber space, facilitating comparisons of different specimens. Further, the authors explore possibilities to utilise the specific properties of the detection methods to determine acoustic material parameters.
ЗАДОВОЛЕНІСТЬ ЖИТТЯМ ТА РОЛЬ ПСИХОФІЗИЧНИХ КОМПОНЕНТІВ У ЯКОСТІ ЖИТТЯ ЛЮДЕЙ ПОХИЛОГО ВІКУ
Authors: Гакман Анна , Дудіцька Світлана , Вілігорський Олександр 
Published: January 2021

Мета. Встановити співвідношення факторів, що впливають на задоволеність життям та роль фізичних і психологічних компонентів у якості життя людей похилого віку. Методи. У процесі дослідження використовували теоретичний аналіз та узагальнення науково-методичної літератури;педагогічні спостереження, методику визначення “Індексу життєвої задоволеності” (Live Satisfaction Index) Б. Ньюгартена (в модифікації Н. Паніної), методику “Шкала задоволеності життям” Е. Дінера, методику визначення якості життя “SF 36”, методи математичної статистики. В опитуванні бралиучасть 504 особи віком 60–65 років, з яких 317 жінок та 187 чоловіків (непрацюючі пенсіонери). Результати. Встановлено, що більшість опитуваних (69,2% жінок та 63,7% чоловіків) мають низький рівень задоволеності життям. Середній рівень задоволеності життям виявлено у 23,08% респондентівжіночої статі та у 25,8% чоловіків. Лише 7,7% опитуваних жінок та 10,5% чоловіків мають високий рівень індексу задоволеності життям. Більшість жінок (75,1%) з низьким індексом вважають, що їх індекс задоволеності життям обумовлений фактором “позитивна оцінка себе і своїх вчинків”, а у62,6%) чоловіків – фактором “інтерес до життя”. Однак, такі фактори як послідовність у досягненні цілей та узгодженість між поставленими та досягнутими цілями виявилися найвагомішими серед осіб з високим рівнем задоволеності життям. Згідно нашого соціологічного опитування, у більшості осіб похилого віку спостерігається низький рівень якості життя як за фізичними, так і психологічними ком- понентами. Висновок. У результаті проведеного дослідження встановлено, що більшість осіб похилого віку мають низький індекс задоволеності життям. За показниками “Шкали задоволеності життям” (SWLS) Е. Дінера жінки і чоловіки теж характеризуються низьким рівнем задоволеності життям. Вище середнього рівня задоволеності життям мають 11,4% жінок та 10,2% чоловіків, середній – відповідно 5,4% та 9,1% і високий – 3,8% та 7,5%. За даними соціологічного опитування (методика SF-36), у більшості жінок і чоловіків похилого віку встановлено низький рівень якості життя. При цьому,низькі показники характерні як для фізичного, так і психологічного компонентів здоров’я.Ключові слова: похилий вік, якість життя, задоволеність життям, фізичний і психологічний компоненти.
Functional and metabolic characteristics of peripheral blood mononuclear phagocytes in patients with different clinical courses of multiple sclerosis
Authors: Koliada O. M. , Vdovichenko N. I. , Kolyada T. I. , Bilozorov O. P. 
Published: January 2021

Functional and metabolic features of intact and stimulated mononuclear phagocytes were studied in patients with different clinical courses of multiple sclerosis, the study included 66 patients with relapsing-remitting and 32 patients with progressive course of multiple sclerosis. The state of the mononuclear phagocytes was characterized by expression of costimulatory molecules and direction of L-arginine metabolism. Relative quantities of CD80, CD86 and PD-L1 positive monocytes were determined with Phycoerytrin-labeled monoclonal antibodies in immunofluorescence test in peripheral blood and after culture in parallel series with addition of: (a) E.coli lipopolysaccharide (a stimulator of TLR4), (b) a single-stranded RNA – preparation ssRNA40/LyoVec (a stimulator of TLR7/8), (c) IL-4 (an anti-inflammatory interleukin). The formation of NO was determined by the amount of nitrite in the culture supernatants, arginase activity was determined in cell lysates of the monocyte fraction. We showed that functional and phenotypic characteristics of monocytes depend on the clinical course of multiple sclerosis. In patients with progressive course, the relative number of CD86+ cells was significantly higher and PD-L1+ cells significantly lower than in patients with relapsing-remitting course and healthy persons, in patients with relapsing-remitting course the number of PD-L1+ cells was increased. The number of CD80+ cells did not show any significant difference in the investigated groups of patients relative to the control group. In vitro stimulation of peripheral blood monocytes with TLR4/8 produced a significant increase in the number of CD86+ and decrease in the number of PD-L1+ cells in patients with the progressive course. In patients with the relapsing-remitting course LPS produced an increase in number of PD-L1+ cells. We did not find any difference in activity of the arginase pathway of L-arginine metabolism in the intact monocyte fraction of peripheral blood in patients with multiple sclerosis versus the control group, but stimulation with TLR4 agonist of mononuclear cells of patients with progressive course caused significant increased arginase activity versus baseline. At the same time, versus control cells arginase activity in patients with the progressive course decreased after LPS treatment, but trended to increase after TLR7/8 treatment. In patients with the relapsing-remitting course these changes had a similar direction but were less expressed. The results may be considered as an indication of the activation of peripheral blood monocytes and their polarization trend in the M1 direction in patients with the progressive course of multiple sclerosis, these changes could be considered as signs of violation of autoimmune regulatory mechanisms in multiple sclerosis.
Effects of antihypertensive treatment on systemic inflammation, oxidative stress and proinflammatory cytokine levels
Authors: Ashcheulova T. V. , Gerasimchuk N. N. , Kovalyova O. N. , Kompaniiets K. N. , Honchar O. V. 
Published: January 2021

Hypertension in its origin is a heterogeneous and multisystemic disease. Evaluation of oxidative stress activity based on the level of 8-iso-PgF2α, proinflammatory activity based on tumour necrosis factor-α, its type I soluble receptor, and C-reactive protein levels is relevant for further understanding of pathogenesis of hypertension and improvement of the early diagnostics of heart failure. 186 hypertensive patients were observed during a 2-months course of treatment, aged 30 to 65 years. Serum levels of 8-iso-PgF2α (n = 34), tumour necrosis factor-α and its type I soluble receptor were determined by ELISA before and after course of treatment. C-reactive protein level was determined by biochemical method. The control group included 16 clinically healthy individuals, aged 27 to 55 years. Hypertensive patients enrolled into the study were randomized into three groups that received different protocols of combined anti-hypertensive therapy: I clinical group – а combination of bisoprolol and indapamid, II – а combination of lacidipine and candesartan, III – а combination of fosinopril sodium and hydrochlorothiazide. On the background of combined antihypertensive therapy, we observed favourable dynamics of 8-iso-PgF2α, tumour necrosis factor-α and its type I soluble receptor, and C-reactive protein levels. Taking into account the insignificance of the correlations revealed, a one-factor dispersion analysis was applied which allowed us to determine the influence of the grade and duration of hypertension on the dynamics of the studied parameters. It has been found that the grade of hypertension is related to an increase in TNF-α and 8-iso-PgF2α serum levels, but not in TNF-α type I soluble receptor, and the duration of hypertension is related to an increase in C-reactive protein, TNF-α and its type I soluble receptor levels, with no relation to the level of 8-iso-PgF2α. Thus, oxidative stress possibly promotes the activation of potentially damaging immune mechanisms mediated by proinflammatory cytokines, nonspecific inflammation and drives the further progression of lesions in the target organs.
Pengaruh Pembelajaran Renang Selama Delapan Minggu Terhadap Peningkatan Kemampuan Dasar Renang Gaya Bebas untuk Pemula Mahasiswa Ilmu Keolahragaan
Authors: Badruzaman Badruzaman , Saputra Yudha M 
Published: January 2021

Tujuan study menginvestigasi pengaruh program pembelajaran renang selama 8 minggu terhadap peningkatan kemampuan dasar renang gaya bebas mahasiswa ilmu keolahragaan tingkat pemula. Pengukuran kemampuan dasar renang mencakup; kemampuan menyelam, mengapung, meluncur, gerakan kaki, gerakan lengan, koordinasi gerakan kaki dan lengan, mengambil nafas, dan kemampuan renang gaya bebas lengkap. Subjek penelitian 30 orang (18 pria dan 12 wanita), rentang usia 19 – 21 tahun. Mereka sebagai perenang pemula. Desain prates-postes tanpa kontrol. Analysis menggunakan Paired samples T test, 2-tailed, p =0.01 . Hasil: Kemampuan menyelam (pra = 17.16, pos = 20.38 Sc, skor T = -12.36. Mengapung (pra = 15.80, pos = 18.37 Sc., T = -14.25). Meluncur (pra = 3.60, pra = 5.03 m, T = -16.13). Gerakan kaki (pra = 5.73, pos = 7.10 m, T = 8.10). Gerakan lengan (pra = 7.88, pos = 10.39 m, T = -17.90). Koordinasi kaki dan lengan (pra = 9, pos = 11.63 m, T = -8.60). Nafas (pra = 1.93, pos = 4.23 f, T = -21.14). Renang lengkap gaya bebas (pra = 11.03, pos = 14.28 m., T = -21.25). Seluruh kemampuan dasar renang hasil pra-postes menunjukkan perbedaan yang signifikan p =0.000.01. Artinya program pembelajaran renang gaya bebas selama 8 minggu, memiliki pengaruh yang signifikan terhadap peningkatan kemampuan dasar renang gaya bebas mahasiswa untuk pemula.Kata kunci: Pembelajaran renang, kemamuan dasar renang, gaya bebas, pemula.
Late Jurassic foraminifera from the southern Waschberg-Ždánice Unit (Klentnice beds, Lower Austria)
Authors: Gebhardt Holger 
Published: January 2021

Abstract
Foraminiferal assemblages from Upper Jurassic Klentnice beds in Lower Austria are described and analysed. The early late Tithonian assemblages comprise 75 foraminiferal taxa and simple diversities reach up to 31 taxa per sample, pointing to comparatively high diversity in general. The assemblages are dominated by lenticulinid forms (Genera Astacolus, Lenticulina, Saracenaria, Vaginulinopsis). Trocholina is the most common genus and present in all samples. Other frequent genera are Marssonella and Neobulimina. Co-occurrence of epifaunal (grazing) herbivores and epi- to deep infaunal active deposit feeders points to mixed assemblages from different sources and supports the concept of turbiditic systems as prevailing sedimentary regimes in the basinal setting.
Analytical method development and validation studies for estimation of anti-psychotic drug (Olanzapine)
Authors: Manjunath Renuka , Jha Deepak Kumar 
Published: January 2021

<p class="abstract"><strong>Background:</strong> Various sophisticated strategies have been raised in conformity with permit the fast separation and quantification about clue aspects concerning complex mixtures of biological matrix. These needs underscored the necessary of analytical instrumentation and the creation of new strategies.</p><p class="abstract"><strong>Methods:</strong> A rapid, accurate, precise, and simple UV then LC-MS/MS analytical methods has been flourished for the determination of Olanzapine (OLZ) in tablet formulation. </p><p class="abstract"><strong>Results:</strong> Chromatographic separation was conducted out on a Phenomenex 250×4.60 mm with an isocratic mobile phase consisting formic acid of 0.1% v/v in Methanol and water at a ratio regarding 92:08v/v and an aggregation run time of 2.5 min. The plasma Olanzapine concentrations were quantified the use of SCIEX API 3000 LC-MS/MS provision geared up along electro spray ionization cleft into the multiple reaction limit mode at m/z 313.4 to 256.3 for Olanzapine; and m/z 327.1 to 270.0 for clozapine respectively. Calibration requirements were organized into the range 5 ng/ml in conformity with 1000 ng/ml for Olanzapine. The effects had been unique and reproducible with the samples prepared by way of liquid-liquid extraction method using Tert-butyl methyl ether extraction in the course of approach improvement trials.</p><p class="AT"><strong>Conclusions:</strong> The novelty on its technique entails the improvement and validation by means of the usage of some quadrant easy pattern decontamination approach and the most sensitive technique with shortest analysis time.</p>