bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Acute Kidney Injury in Critically Ill Neonates: A Systematic Review and Meta-Analysis
Authors: Hu Qian , Li Shao-Jun , Chen Qian-Ling , Chen Han , Li Qiu , Wang Mo 
Published: July 2021

Background and Objective: Acute kidney injury (AKI) is recognized as an independent risk factor for mortality and long-term poor prognosis in neonates. The objective of the study was to identify the risk factors for AKI in critically ill neonates to provide an important basis for follow-up research studies and early prevention.Methods: The PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, WanFang Med, SinoMed, and VIP Data were searched for studies of risk factors in critically ill neonates. Studies published from the initiation of the database to November 19, 2020, were included. The quality of studies was assessed by the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality (AHRQ) checklist. The meta-analysis was conducted with Stata 15 and drafted according to the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement.Results: Seventeen studies (five cohort studies, ten case-control studies, and two cross-sectional studies) were included in meta-analysis, with 1,627 cases in the case group and 5,220 cases in the control group. The incidence of AKI fluctuated from 8.4 to 63.3%. Fifteen risk factors were included, nine of which were significantly associated with an increased risk of AKI in critically ill neonates: gestational age [standardized mean difference (SMD) = −0.31, 95%CI = (−0.51, −0.12), P = 0.002], birthweight [SMD = −0.37, 95%CI = (−0.67, −0.07), P = 0.015], 1-min Apgar score [SMD = −0.61, 95%CI = (−0.78, −0.43), P = 0.000], 5-min Apgar score [SMD = −0.71, 95%CI = (−1.00, −0.41), P = 0.000], congenital heart disease (CHD) [odds ratio (OR) = 2.94, 95%CI = (2.08, 4.15), P = 0.000], hyperbilirubinemia [OR = 2.26, 95%CI = (1.40, 3.65), P = 0.001], necrotizing enterocolitis (NEC) [OR = 6.32, 95%CI = (2.98, 13.42), P = 0.000], sepsis [OR = 2.21, 95%CI = (1.25, 3.89), P = 0.006], and mechanical ventilation [OR = 2.37, 95%CI = (1.50, 3.75), P = 0.000]. Six of them were not significantly associated with AKI in critically ill neonates: age [SMD = −0.25, 95%CI = (−0.54, 0.04), P = 0.095], male sex [OR = 1.10, 95%CI =(0.97, 1.24), P = 0.147], prematurity [OR = 0.90, 95%CI(0.52, 1.56), P = 0.716], cesarean section [OR = 1.52, 95%CI(0.77, 3.01), P = 0.234], prenatal hemorrhage [OR = 1.41, 95%CI = (0.86, 2.33), P = 0.171], and vancomycin [OR = 1.16, 95%CI = (0.71, 1.89), P = 0.555].Conclusions: This meta-analysis provides a preliminary exploration of risk factors in critically ill neonatal AKI, which may be useful for the prediction of AKI.Systematic Review Registration: PROSPERO (CRD42020188032).
Role of Serosal TRPV4-Constituted SOCE Mechanism in Secretagogues-Stimulated Intestinal Epithelial Anion Secretion
Authors: Cui Yinghui , Chu Fenglan , Yin Kai , Chen Xiongying , Wan Hanxing , Luo Gang , Dong Hui , Xu Feng 
Published: July 2021

As little is known about the role of calcium (Ca2+) signaling mediating the small intestinal epithelial anion secretion, we aimed to study its regulatory role in secretagogue-stimulated duodenal anion secretion and the underlying molecular mechanisms. Therefore, intestinal anion secretion from native mouse duodenal epithelia was examined with Ussing chambers to monitor PGE2-, 5-HT-, and CCh-induced short-circuit currents (Isc). PGE2 (10 μM) and 5-HT (10 μM) induced mouse duodenal Isc, markedly attenuated by serosal Ca2+-free solution and selective blockers of store-operated Ca2+ channels on the serosal side of the duodenum. Furthermore, PGE2- and 5-HT-induced duodenal Isc was also inhibited by ER Ca2+ chelator TPEN. However, dantrolene, a selective blocker of ryanodine receptors, inhibited PGE2-induced duodenal Isc, while LiCl, an inhibitor of IP3 production, inhibited 5-HT-induced Isc. Moreover, duodenal Isc response to the serosal applications of both PGE2 and 5-HT was significantly attenuated in transient receptor potential vanilloid 4 (TRPV4) knockout mice. Finally, mucosal application of carbachol (100 μM) also induced duodenal Isc via selective activation of muscarinic receptors, which was significantly inhibited in serosal Ca2+-free solution but neither in mucosal Ca2+-free solution nor by nifedipine. Therefore, the serosal TRPV4-constituted SOCE mechanism is likely universal for the most common and important secretagogues-induced and Ca2+-dependent intestinal anion secretion. These findings will enhance our knowledge about gastrointestinal (G.I.) epithelial physiology and the associated G.I. diseases, such as diarrhea and constipation.
Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats
Authors: Lai Wenxiu , Mo Yulin , Wang Dongtao , Zhong Ying , Lu Lujiao , Wang Jiajia , Cui Liao , Liu Yanzhi , Yang Yajun 
Published: July 2021

Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear. In the present study, we determined the parameters related to microstructure and function of bone tissue, bone microcirculation, and TXNIP signaling to investigate the beneficial effects of tanshinol on skeleton and its molecular mechanism in GIO rats. Male Sprague-Dawley rats aged 4 months were administrated orally with distilled water (Con), tanshinol (Tan, 25 mg kg−1 d−1), prednisone (GC, 5 mg kg−1 d−1) and GC plus tanshinol (GC + Tan) for 14 weeks. The results demonstrated that tanshinol played a significant preventive role in bone loss, impaired microstructure, dysfunction of bone metabolism and poor bone quality, based on analysis of correlative parameters acquired from the measurement by using Micro-CT, histomorphometry, ELISA and biomechanical assay. Tanshinol also showed a significant protective effect in bone microcirculation according to the evidence of microvascular perfusion imaging of cancellous bone in GIO rats, as well as the migration ability of human endothelial cells (EA.hy926, EA cells). Moreover, tanshinol also attenuated GC-elicited the activation of TXNIP signaling pathway, and simultaneously reversed the down-regulation of Wnt and VEGF pathway as manifested by using Western-blot method in GIO rats, EA cells, and human osteoblast-like MG63 cells (MG cells). Collectively, our data highlighted that tanshinol ameliorated poor bone health mediated by activation of TXNIP signaling via inhibiting microcirculation disturbance and the following impaired bone formation in GIO rats.
Differences in Facial Expression Recognition Between Unipolar and Bipolar Depression
Authors: Ruihua Ma , Meng Zhao , Nan Chen , Panqi Liu , Hua Guo , Sijia Liu , Jing Shi , Ke Zhao , Yunlong Tan , Shuping Tan , Fude Yang , Li Tian , Zhiren Wang 
Published: July 2021

PurposeTo explore the differences in facial emotion recognition among patients with unipolar depression (UD), bipolar depression (BD), and normal controls.MethodsThirty patients with UD and 30 patients with BD, respectively, were recruited in Zhumadian Second People’s Hospital from July 2018 to August 2019. Fifteen groups of facial expressions including happiness, sadness, anger, surprise, fear, and disgust were identified.ResultsA single-factor ANOVA was used to analyze the facial expression recognition results of the three groups, and the differences were found in the happy-sad (P= 0.009), happy-angry (P= 0.001), happy-surprised (P= 0.034), and disgust-surprised (P= 0.038) facial expression groups. The independent sampleT-test analysis showed that compared with the normal control group, there were differences in the happy-sad (P= 0.009) and happy-angry (P= 0.009) groups in patients with BD, and the accuracy of facial expression recognition was lower than the normal control group. Compared with patients with UD, there were differences between the happy-sad (P= 0.005) and happy-angry (P= 0.002) groups, and the identification accuracy of patients with UD was higher than that of patients with BD. The time of facial expression recognition in the normal control group was shorter than that in the patient group. Using happiness-sadness to distinguish unipolar and BDs, the area under the ROC curve (AUC) is 0.933, the specificity is 0.889, and the sensitivity is 0.667. Using happiness-anger to distinguish unipolar and BD, the AUC was 0.733, the specificity was 0.778, and the sensitivity was 0.600.ConclusionPatients with UD had lower performance in recognizing negative expressions and had longer recognition times. Those with BD had lower accuracy in recognizing positive expressions and longer recognition times. Rapid facial expression recognition performance may be as a potential endophenotype for early identification of unipolar and BD.
When Problems Only Get Bigger: The Impact of Adverse Childhood Experience on Adult Health
Authors: Novais Márcia , Henriques Teresa , Vidal-Alves Maria João , Magalhães Teresa 
Published: July 2021

Introduction: Previous studies have shown that adverse childhood experiences negatively impact child development, with consequences throughout the lifespan. Some of these consequences include the exacerbation or onset of several pathologies and risk behaviors.Materials and Methods: A convenience sample of 398 individuals aged 20 years or older from the Porto metropolitan area, with quotas, was collected. The evaluation was conducted using an anonymous questionnaire that included sociodemographic questions about exposure to adverse childhood experiences, a list of current health conditions, questions about risk behaviors, the AUDIT-C test, the Fagerström test and the Childhood Trauma Questionnaire–brief form. Variables were quantified to measure adverse childhood experiences, pathologies, and risk behaviors in adult individuals for comparison purposes.Results: Individuals with different forms of adverse childhood experiences present higher rates of smoking dependence, self-harm behaviors, victimization of/aggression toward intimate partners, early onset of sexual life, sexually transmitted infections, multiple sexual partners, abortions, anxiety, depression, diabetes, arthritis, high cholesterol, hypertension, and stroke. Different associations are analyzed and presented.Discussion and Conclusions: The results show that individuals with adverse childhood experiences have higher total scores for more risk behaviors and health conditions than individuals without traumatic backgrounds. These results are relevant for health purposes and indicate the need for further research to promote preventive and protective measures.
Prevalence of Mental Disorders in the WHO Eastern Mediterranean Region: A Systematic Review and Meta-Analysis
Authors: Zuberi Alina , Waqas Ahmed , Naveed Sadiq , Hossain Md Mahbub , Rahman Atif , Saeed Khalid , Fuhr Daniela C. 
Published: July 2021

Objectives: To synthesize the prevalence of mental and substance use disorders in countries of the Eastern Mediterranean Region (EMR) of the World Health Organization.Methods: The literature search was conducted across several databases in two phases. First, we searched for systematic reviews and/or meta-analyses published before 2014, reporting prevalence estimates for mental disorders in the EMR. Then, we identified new primary cross-sectional or longitudinal studies published between 2014 and 2020. Studies were included if they had a sample size of ≥ 450 and were conducted among the general adult population. Current, period and lifetime prevalence estimates for each disorder were pooled using random-effects meta-analyses, and subgroup analyses and meta-regressions were conducted.Findings: Prevalence estimates were extracted from 54 cross-sectional studies across 15 countries within the EMR. Pooled analyses of current, period and lifetime prevalence showed the highest prevalence for depression (14.8%, 95% confidence interval, CI: 10.7–20.1%), followed by generalized anxiety disorder (GAD) (10.4%, 95% CI: 7.1–14.7%), post-traumatic stress disorder (7.2%, 95% CI: 2.9–16.6%), substance use (4.0%, 95% CI: 3.1–5.2%), obsessive compulsive disorder (2.8%, 95% CI: 1.6–4.9%), phobic disorders (1.8%, 95% CI: 1.1–2.8%), panic disorders (1.1%, 95% CI: 0.6–2.2%), bipolar disorders (0.7%, 95% CI: 0.3–1.6%), and psychosis (0.5%, 95% CI: 0.3–0.9%). Populations exposed to adverse events had higher prevalence of mental disorders than the general population. Period and lifetime prevalence showed little difference across mental disorders. More pronounced differences in prevalence were seen for depression and GAD, specifically between current and lifetime prevalence (depression: current prevalence 20.5% (95% CI: 14.9–27.4%), vs. lifetime prevalence: 4.2% (95%CI: 1.8–9.6%); GAD: current prevalence 10.3% (95% CI: 6.1–17.0), vs. lifetime prevalence: 4.5% (95% CI: 2.4–8.3%). Differences between current and lifetime prevalence of mental disorders may be due to the use of different screening instruments and thresholds being applied.Conclusion: The prevalence of mental and substance use disorders in the EMR is high. Despite substantial inter-survey heterogeneity, our estimates align with previous global and regional data on mental disorders. Our meta-review provides new evidence on the burden of mental health problems in the EMR.Systematic Review Registration: PROSPERO, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020187388.
Be a Mom, a Web-Based Intervention to Promote Positive Mental Health Among Postpartum Women With Low Risk for Postpartum Depression: Exploring Psychological Mechanisms of Change
Authors: Monteiro Fabiana , Pereira Marco , Canavarro Maria Cristina , Fonseca Ana 
Published: July 2021

Background: This study explored whether Be a Mom, a brief and unguided cognitive behavioral web-based intervention, was effective in promoting psychological processes (self-compassion, psychological flexibility, emotion regulation) among low-risk postpartum women. Effects of Be a Mom in psychological processes compared with a control group were examined at post-intervention and at 4-months follow-up. Additionally, this work explored whether changes in psychological processes mediated improvements in positive mental health at postintervention.Methods: In total, 367 postpartum women presenting low risk for postpartum depression were randomly assigned to the intervention group (n = 191) or to a waiting-list control group (n = 176).Results: Compared with the control group, the intervention group reported significantly greater baseline to postintervention increases in self-compassion. No significant effects were found at the 4-month follow-up. Multilevel mediation showed that self-compassion improvements significantly mediated improvements in positive mental health among the intervention group. No significant results were found for psychological flexibility or emotion regulation.Conclusions: This study suggests that Be a Mom has the potential to cultivate self-compassion among low-risk postpartum women and that this may be a key mechanism for promoting positive mental health in this context.Clinical Trial Registration:www.clinicaltrials.gov, identifier: NCT04055974.
The Influence of Leisure Activity Types and Involvement Levels on Leisure Benefits in Older Adults
Authors: Li Jintian , Zeng Baogen , Li Peiyan 
Published: July 2021

Purpose: To explore the types of leisure activities, the degree of activity involvement, and the relationship between leisure benefits in older adults in cities and towns in Northern Guangdong, China; to provide valuable references for formulating related policies on the leisure industry for relevant governing bodies and for gaining the optimal benefits for industry business people and leisure enthusiasts.Methods: After searching for a large amount of literature and expert consultations, a questionnaire on the leisure involvement and leisure benefits scale was constructed. The participants aged 60 years or older were recruited as the survey population. By using SPSS statistics 21.0, the raw and processed data in this study were analyzed and interpreted.Results: (1) The approach that the leisure involvement levels were divided into subjective and objective involvement levels to predict leisure benefits was more comprehensive and reliable than uni-level prediction. Among them, the overall leisure involvement level had a significant positive effect on the leisure benefits of leisure participants; the performance of the subjective involvement level to enhance the leisure benefits comprehensively surpassed the objective involvement level. (2) The effect of leisure involvement levels on leisure benefits was affected by the type of leisure, which was manifested as physiological and psychological leisure pleasure; the degree of leisure involvement had an inverted U-shaped relationship with its emotional leisure benefits. For individuals with physiological hedonistic leisure, the degree of leisure involvement had an inverted U-shaped relationship with its emotional, social, and self-realized leisure interests. (3) For individuals with psychological leisure, the degree of leisure involvement was positively U-shaped with its social and self-affirmed leisure benefits. However, this finding needs to be confirmed by further research.Conclusion: There are two types of linear and curvilinear relationships between the degree of leisure involvement and leisure benefits, which makes the connection between leisure involvement and leisure benefits deviate from the linearity in a particular situation and present an inverted U-shaped or positive U-shaped relationship, which shows, when the individuals are under- or over-volume leisure activities involvement, they will not create excellent leisure benefits.
Do We Need a Specific Guideline for Assessment and Improvement of Acromegaly Patients Adherence?
Authors: Kamusheva Maria , Parvanova Alexina , Rusenova Yanitsa , Vandeva Silvia , Elenkova Atanaska 
Published: July 2021

Background: Adherence to therapy is one of the most important elements during the therapeutic process ensuring the predefined therapeutic outcomes. The aim is to analyze the need and importance of treatment adherence guideline for acromegaly patients and the possibilities for its development and implementation in Bulgaria.Methods: A set of methods was applied: (1) a literature review in the electronic database for identification of articles and guidelines related to adherence and acromegaly; (2) analysis of Bulgarian legislative documents; (3) a pilot study for assessment of the level of treatment adherence among hospitalized Bulgarian acromegaly patients in 2018; (4) a plan for development and implementation of specific guideline was created entitled BULMEDACRO - BULgarian guideline for MEdication aDherence assessment and improvement in ACROmegaly.Results: No specific guidelines for evaluation, monitoring, reporting and/or improving adherence in acromegaly patients has been found in the literature. Requirements for regular assessment of the level of adherence, application of appropriate methods for improvement and monitoring are not sufficiently formulated and mandatory. The pilot study confirmed that therapy adherence among Bulgarian patients with acromegaly is relatively high as almost 90% of patients report that they strictly comply with their prescribed treatment regimen. It is necessary, however, a specific guideline focused on the methods for assessment and improvement of adherence, in order to ensure monitoring and follow-up of acromegaly patients.Conclusions: Patients with acromegaly should be the focus of specially designed national programs, initiatives and/or guidelines for regular evaluation and improvement of the adherence level. Despite the difficulties and the lack of an adequate legal basis, successive steps initiated by different stakeholder are needed.
Quenching of Isovector and Isoscalar Spin-M1 Excitation Strengths in N = Z Nuclei
Authors: Matsubara Hiroaki , Tamii Atsushi 
Published: July 2021

Spin-M1 excitations of nuclei are important for describing neutrino reactions in supernovae or in neutrino detectors since they are allowed transitions mediated by neutral current neutrino interactions. The spin-M1 excitation strength distributions in self-conjugate N=Z nuclei were studied by proton inelastic scattering at forward angles for each of isovector and isoscalar excitations as reported in H. Matsubara et al., Phys. Rev. Lett. 115, 102501 (2015). The experiment was carried out at the Research Center for Nuclear Physics, Osaka University, employing a proton beam at 295 MeV and the high-resolution spectrometer Grand Raiden. The measured cross-section of each excited state was converted to the squared nuclear matrix elements of spin-M1 transitions by applying a unit cross-section method. Comparison with predictions by a shell-model has revealed that isoscalar spin-M1 strengths are not quenched from the prediction although isovector spin-M1 strengths are quenched similarly with Gamow-Teller strengths in charged-current reactions. This finding hints at an important origin of the quenching of the strength relevant to neutrino scattering, that is, the proton-neutron spin-spin correlation in the ground state of the target nucleus. In this manuscript we present the details of the unit cross-section method used in the data analysis and discuss the consistency between the quenching of the isoscalar magnetic moments and that of the isoscalar spin-M1 strengths.
Isothermal Oxidation Performance of Laser Cladding Assisted with Preheat (LCAP) Tribaloy T-800 Composite Coatings Deposited on EN8
Authors: Nyadongo Sipiwe Trinity , Pityana Sisa Lesley , Olakanmi Eyitayo Olatunde 
Published: July 2021

It is anticipated that laser cladding assisted with preheat (LCAP)-deposited Tribaloy (T-800) composite coatings enhances resistance to structural degradation upon exposure to elevated-temperature oxidation service environments. The oxidation kinetics of LCAP T-800 composite coatings deposited on EN8 substrate and its mechanisms have not been explored in severe conditions that are similar to operational parameters. The isothermal oxidation behaviour of the T-800 composite coating deposited on EN8 via LCAP was studied at 800 °C in air for up to 120 h (5 × 24 h cycles) and contrasted to that of uncoated samples. The mass gain per unit area of the coating was eight times less than that of the uncoated EN8 substrate. The parabolic rate constant (Kp) for EN8 was 6.72 × 10−12 g2·cm−4·s−1, whilst that for the T-800 composite coating was 8.1 × 10−13 g2·cm−4·s−1. This was attributed to a stable chromium oxide (Cr2O3) layer that formed on the coating surface, thereby preventing further oxidation, whilst the iron oxide film that formed on the EN8 substrate allowed the permeation of the oxygen ions into the oxide. The iron oxide (Fe2O3) film that developed on EN8 spalled, as evidenced by the cracking of oxide when the oxidation time was greater than 72 h, whilst the Cr2O3 film maintained its integrity up to 120 h. A parabolic law was observed by the T-800 composite coating, whilst a paralinear law was reported for EN8 at 800 °C up to 120 h. This coating can be used in turbine parts where temperatures are <800 °C.