bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Do People Living With HIV Acquire HIV Related Information: A Qualitative Evaluation of Jakarta Setting
Authors: Mahathir Mahathir , Wiarsih Wiwin , Permatasari Henny 
Published: February 2021

Introduction: People living with HIV are fully aware of their risk behavior and future threats that might arise. The rapid progress of HIV serves the population with many options of healthcare services and treatments. Insufficient knowledge and information will only lower the outcomes of HIV eradication efforts. The ultimate goals to eradicate HIV are to upscale status notification and treat all with appropriate antiretroviral and viral suppression, but it needs sufficient information to administer. Programs and interventions have already been proposed, but an inquiry is needed to ensure all the information is actually there. The study aimed to explore the experience of people living with HIV acquiring HIV-related information.Methods: This study used phenomenological qualitative study and in-depth interviews were conducted to 12 people living with HIV. Semi-structured questions were delivered to all participants which explored their tangible experience in terms of nurturing sufficient HIV-related information.Results: The study found four consequential themes: non-government organizations play a major role in HIV education, peers are a comfortable platform to discuss, it is all over the media and healthcare personnel are a source of knowledge. Conclusion: The distribution of HIV information and knowledge is now widespread. This situation marks part of the success in fighting HIV. Remarkable attempts can be maintained by optimizing the viable option of information delivery. Keyword: HIV knowledge; people living with HIV; qualitative study
The Relationship between Family Harmony with Stress, Anxiety, and Depression in Adolescents
Authors: Windarwati Heni Dwi , Budiman Amin Aji , Nova Renny , Ati Niken Asih Laras , Kusumawati Mira wahyu 
Published: February 2021

Introduction: Adolescents are a group vulnerable to mental health problems, including stress, anxiety, and depression. This study aimed to examine the interlink of a harmonious family with stress, anxiety, and depression in adolescents.Methods: This study employed descriptive correlational design with cross-sectional approach and examined 851 high school adolescents aged between 16-18 years who were recruited using a total sampling method from five high school in Malang City. Stress, anxiety and depression in adolescents was assessed employing the Depression Anxiety Stress Scale (DASS - 21), while, to assess family harmony, a questionnaire developed by the researcher was used. Data were analyzed through descriptive statistics and bivariate tests using Spearman Rank Correlation.Results: It was revealed that 428 adolescents (50.3%) were male, 321 adolescents (37.7%) came from parents who worked privately, and 482 adolescents (56.6%) had their parents' social status above the minimum wage standard. Eight hundred and two adolescents (94.2%) had harmonious families, while the remaining 49 adolescents (5.8%) had non-harmonious families. Our study concluded that family harmony had a significant relationship with adolescent stress levels (p-value 0.013). On the other hand, the analysis showed that family harmony was not related to adolescents' anxiety (p-value 0.071) and depression level (p-value 0.13). A harmonious family makes children mentally healthy, able to adapt to the environment while a family that is not harmonious can trigger stress because conditions are not as expected, coupled with the burden of schoolwork, stressors from teachers and peers.Conclusion:The results of the research showed that harmony in the family had a significant effect on stress in adolescents. Therefore, it is necessary to provide education and counseling to the family to prevent fights in the family so that it can reduce the emergence of stress in adolescents.
Responsibilities of PT. GO-JEK Indonesia Semarang as Business Services Provider of Consumer Protection Online Services by Law Number 8 of 1999 Consumer Protection1999 CONSUMER PROTECTION
Authors: Pradani Annisa Rizqi 
Published: February 2021

PT. GO-JEK Indonesia utilizing the technology by issuing a GO-JEK application. People who will use the services-JEK Indonesia PT.GO application must download an app on a smartphone GO-JEK. The application, the customer is required to fill the data of identity. Charging the identity of the data, the driver will know the identity of the customer. Genesis ever happening to one of the customers PT.GO-JEK Indonesia Semarang is Ria (not her real name) use the services of GO-JEK driver got terror threat for comment after using the services of GO-JEK, of course is very detrimental to customers where the identity given to PT.GO-JEK Indonesia misused by the bad faith. This study aims to determine the responsibility of PT. GO-JEK Indonesia Semarang against losses incurred in terms of the confidentiality of customers' identities. This study uses a qualitative approach that is normative approach with the Act. Specifications spefikasi descriptive study clearly describe later with legal theory and practice of positive law linked to the research conducted. Responsibility PT.GO-JEK Indonesia Semarang to customers have been pursued by the Company by making the latest software in order to safeguard the identity of customers regarding compensation The Company provides compensation in accordance with the rules and regulations that have made the Company. Responsibility and compensation in accordance with the rules of Law No. 8 of 1999 on Consumer Protection.Keywords: Responsibility; Customer; PT.GO-JEK Indonesia
Nipping Adipocyte Inflammation in the Bud
Authors: Griffin Michael J. 
Published: February 2021

Abstract
Adipose tissue inflammation continues to represent a significant area of research in immunometabolism. We have identified a transcription factor, EBF1, which crucially regulates the expression of numerous inflammatory loci in adipocytes. However, EBF1 appears to do so without physically binding to these inflammatory genes. Our research is currently focused on understanding this discrepancy, and we believe that future findings could pave the road for drug development aimed to block adipose inflammation at its source.
PENGARUH PERKECAMBAHAN GABAH TERHADAP RENDEMEN, KUALITAS FISIK DAN NILAI SENSORI BERAS
Authors: Rahman Andi Nur Faidah , Asfar Muhammad , Suwandi Nurhadi 
Published: February 2021

<p class="Abstrak">Beras merupakan makanan utama orang Indonesia. Oleh sebab itu produksi beras yang bermutu sangat penting untuk memenuhi asupan gizi masyarakat. Berdasarkan hasil penelitian yang berjudul pengaruh perkecambahan terhadap peningkatan mutu beras, bahwa perkecambahan gabah sebelum digiling menjadi beras dapat meningkatkan nilai gizi beras. Namun belum diketahui efek dari perkecambahan gabah terhadap rendemen, kualitas fisik dan nilai sensori beras. Tujuan penelitian ini adalah untuk mengetahui pengaruh perkecambahan gabah terhadap rendemen, kualitas fisik (persentase beras kepala, beras patah, dan beras menir) dan nilai sensori (warna, aroma, rasa, dan tekstur) nasi dari beras yang dihasilkan. Penelitian ini menggunakan rancangan acak lengkap satu faktorial. Apabila data hasil analisis statistik berbeda nyata maka akan dilanjutkan dengan uji lanjut Duncan. Hasil penelitian menunjukkan bahwa rendemen beras setelah dikecambahkan mengalami penurunan. Panjang kecambah berpengaruh sangat nyata pada taraf 1% terhadap kualitas fisik beras seperti persentase beras kepala, beras patah dan beras menir, dan berpengaruh nyata pada taraf 5% terhadap parameter warna dan rasa nasi. Kesimpulan hasil penelitian adalah semakin panjang kecambah gabah, maka rendemen, kualitas fisik dan nilai sensori beras cenderung menurun.</p><p class="Abstrak"> </p><p class="Abstrak"><strong><span lang="EN-GB">The Effect of Grain Germination on Yield, Physical Quality, and Rice Sensory Value</span></strong></p><p class="Abstrak"><span lang="EN-GB">Rice is the main food for Indonesians. Therefore the quality of rice production is very important to fulfill the nutritional intake of the community. Based on the results of research cited about effect of germinatioan to improve rice quality that germination of grain before milling into rice can increase the nutritional value of rice. However, the effect of grain germination is unknown on the yield, physical quality and sensory value of rice. The purpose of this study was to determine the effect of grain germination on the yield, physical quality (percentage of head, broken, and groats of rice) and rice sensory (colour, flavour, taste, and texture) value of rice produced. This research uses a completely factorial completely randomized design. If the results of the statistical analysis differ significantly, it will be continued with Duncan tests. The results showed that the yield of rice after germination had decreased. Sprout length has a very significant effect on the level of 1% on the physical quality of rice such as percentage of head, broken, and groats of rice and has a significant effect on the level of 5% on the colour and flavour parameters of rice. The conclusion of the research is the longer the grain sprouts, the yield, physical quality and sensory value of rice tends to decrease.</span></p>
Social Reward and Support Effects on Exercise Experiences and Performance: Evidence from Parkrun
Authors: Davis Arran , MacCarron Pádraig , Cohen Emma 
Published: February 2021

Abstract
There is growing academic, civic and policy interest in the public health benefits of community-based exercise events. Shifting the emphasis from competitive sport to communal activity, these events have wide appeal. In addition to physical health benefits, regular participation can reduce social isolation and loneliness through opportunities for social connection. Taking a broad evolutionary and social psychological perspective, we develop and test the hypothesis that social reward and support are associated with more positive exercise experiences and greater performance outputs. Using a repeated-measures design, we examine the influence of social perceptions and behaviour on subjective enjoyment, energy, fatigue, effort, and objective performance (run times) among a UK sample of parkrun participants. Social factors were associated with greater subjective enjoyment and energy. Higher subjective energy, in turn, was associated with faster run times, without any corresponding increase in perceived effort. No significant main effects of social factors on fatigue, performance or effort were detected. The role of social structural factors has long been recognised in public health approaches to physical activity. Our results motivate greater research attention on how positive and rewarding social behaviours and experiences – particularly subjective enjoyment and energy, and perceptions of community social support and belonging - influence exercise-related behaviour, psychology and physiology, and promote health through collective physical activity. The research also supplements traditional emphases on social facilitation and team sport that have dominated sport and exercise psychology and offers new avenues for understanding the deep connections among psychological, social and physical function in everyday health.
A dynamic basal complex modulates mammalian sperm movement
Authors: Khanal Sushil , Leung Miguel , Royfman Abigail , Fishman Emily , Saltzman Barbara , Bloomfield-Gadêlha Hermes , Mordehai Tzvya Zeev Ben , Avidor-Reiss Tomer 
Published: February 2021

Abstract
Reproductive success depends on efficient sperm movement driven by dynein-mediated microtubule sliding in the axoneme 1-3. Models predict sliding at the base of the tail – the centriole – but such sliding has never been observed 4,5. Centrioles are evolutionarily-ancient organelles with a conserved architecture 6-8, and their rigidity is thought to restrict microtubule sliding 1. Here, we show that, in mammalian sperm, the atypical distal centriole (DC) and its surrounding atypical pericentriolar matrix 9,10 form a dynamic basal complex (DBC) that facilitates a cascade of internal sliding deformations, coupling tail beating with asymmetric head kinking. During asymmetric tail beating, the DC’s right side and its surroundings slide ~300 nm rostrally relative to the left side. This deformation is transmitted through the DBC to the head-tail junction; as a result, the head tilts to the left, generating a kinking motion. These findings suggest that the DBC evolved to act as a mechanotransducer, coupling sperm head and tail into a single self-coordinated system. The DBC may act as a morphological computer 11, regulating tail beating from external feedback imparted to the head during sperm navigation. We anticipate our findings will enable studies of coordinated motion in sperm and cilia in many contexts.
Trastuzumab Administration During Pregnancy: Un Update
Authors: Andrikopoulou Angeliki , Apostolidou Kleoniki , Chatzinikolaou Spyridoula , Bletsa Garyfalia , Zografos Eleni , Dimopoulos Meletios-Athanasios , Zagouri Flora 
Published: February 2021

Abstract
Background
Over than one third (28–58%) of pregnancy-associated breast cancer (PABC) cases are characterized by positive epidermal growth factor receptor 2-positive (HER2) expression. Trastuzumab anti-HER2 monoclonal antibody is still the benchmark treatment of HER2-positive breast tumors. However, FDA has categorized Trastuzumab as a category D drug for pregnant patients with breast cancer. This systemic review aims to synthesize all currently available data of trastuzumab administration during pregnancy and provide an updated view of the effect of trastuzumab on fetal and maternal outcome.
Methods
Eligible articles were identified by a search of MEDLINE bibliographic database and ClinicalTrials.gov for the period up to 01/09/2020; The algorithm consisted of a predefined combination of the words “breast”, “cancer”, “trastuzumab” and “pregnancy”. This study was performed in accordance with the PRISMA guidelines.
Results
A total of 28 eligible studies were identified (30 patients, 32 fetuses). In more than half of cases, trastuzumab was administered in the metastatic setting. The mean duration of trastuzumab administration during gestation was 15.7 weeks (SD: 10.8; median: 17.5; range: 1–32). Oligohydramnios or anhydramnios was the most common (58.1 %) adverse event reported in all cases. There was a statistically significant decrease in oligohydramnios/anhydramnios incidence in patients receiving trastuzumab only during the first trimester (P = 0.026, Fisher’s exact test). In 43.3% of cases a completely healthy neonate was born. 41.7 % of fetuses exposed to trastuzumab during the second and/or third trimester were born completely healthy versus 75.0% of fetuses exposed exclusively in the first trimester. All mothers were alive at a median follow-up of 47.0 months (ranging between 9 and 100 months). Of note, there were three cases (10%) of cardiotoxicity and decreased ejection fraction during pregnancy.
Conclusions
Overall, treatment with trastuzumab should be postponed until after delivery, otherwise pregnancy should be closely monitored.
Analyzing China’s provincial pollution and its influencing factors: A spatial analysis
Authors: Wang Xing , Zhou Dequn 
Published: February 2021

Abstract
In-depth analyses of the spatial heterogeneity in pollution, and the causes of differences are of great importance for contributing to provide reference for reduction policies. However, a spatial analysis of the existence and mechanism of China’s pollution is still ignored. Using the province-level data of thirty provinces in China over 2005–2017, this paper constructs a spatial Durbin model (SDM) to empirically address the existence and spatial transmission mechanism of pollution. The main results are as follows: first, China’s pollution shows significant characteristics of spatial dependence and clustering from global and local perspectives, indicating that the existence of spatial autocorrelation in pollution across regions. Second, both per capita GDP and urbanization have positive impacts on pollution, but the impacts of environmental regulation and FDI are insignificant. Third, urbanization not only directly influences pollution, but also indirectly influences pollution. Our analysis provides valuable information for developing policies to effectively alleviate pollution.
Dynamic Modelling of Tetrazolium Based Microbial Toxicity Assay – A Parametric Proxy of Traditional Dose-Response Relationship
Authors: Philus Chris Daniel , Mahanty Biswanath 
Published: February 2021

Abstract
Microbial toxicity of test substances in tetrazolium assay is often quantified while referring to IC50 values. However, the implication of such estimates is very limited and can differ across studies depending on prevailing test conditions. In this work, a factorial design-based end-point microbial assay was adopted, which suggests significant interaction (P = 0.041) between inoculum and tetrazolium dose on formazan production. A dynamic model framework was proposed to be incorporated in toxicity assay, that not only captures the nonlinear interdependency between biomass, substrate, formazan content but also measure the toxicity in terms of inhibition parameter. Microbial growth, glucose uptake, formazan production in presence and absence of heavy metal toxicant (Cu2+) in designed batch studies were utilized for sequential estimation of model parameters and their bootstrap confidence intervals. A logistic growth model (R2 > 0.96) with multiplicative inhibition terms fit the experimental data reasonably well. Dynamic relative sensitivity analysis revealed that both microbial growth and formazan production profiles were sensitive to toxicant inhibition parameter. The adoption of a dynamic model framework as a stable index for the toxic potential of test substances can be extended to design a versatile, robust in-vitro assay system.
Molecular Speciation of Phosphorus in Soil Under Various Long-Term Fertilization Regimes
Authors: Li Xue , Wen Qiuxiang , Zhang Shiyu , Li Na , Yang Jinfeng , Han Xiaori 
Published: February 2021

Abstract
Aims The objectives of this study were to examine the long-term substitution of mineral phosphorus (P) fertilizers with manure (M) plus nitrogen (N) fertilizers and how they affect the forms of P that occur in soil, soil P distribution, and plant growth.Methods We used a solution of 31P nuclear magnetic resonance (31P-NMR) spectroscopy to study the correlations between long-term fertilization regimes and the forms of P that occur at different soil depths. Then we investigated yield, plant growth, and soil properties.Results A 40-year field experiment showed that the use of M + N fertilizers can significantly improve plant growth and yield. The proportion of organic P in the 20-40 cm soil layer was significantly increased by long-term M fertilization. The concentrations of various forms of P (orthophosphate, pyrophosphate, diesters, monoesters, and total inositol hexakisphosphate, IHP) in topsoil increased significantly with the combination of M with N + P mineral fertilization. The addition of M greatly increased the stereoisomers of IHP (myo-IHP, scyllo-IHP, neo-IHP, and D-chiro-IHP) and the proportion and concentration of corrected diesters. There were no significant differences in the pyrophosphate contents of the 40-60 cm soil layer according to fertilization type and year of fertilization. There were also no significant differences in IHP stereoisomers and diesters according to fertilization year. The P forms that contributed to corn yield were orthophosphate, diester, and IHP. Further, pyrophosphate made no significant contribution to corn growth. Conclusions Over the long-term, pig manure can significantly increase the amount of orthophosphate that is directly absorbed by crops and the amount of IHP stereoisomers that can be used by plants. Orthophosphate and IHP are the two key factors that have a positive effect on plant growth.
The proinflammatory response induced by the Cytolethal Distending Toxin depends on cGAS
Authors: Pons Benoît J. , Pettes-Duler Aurélie , Naylies Claire , Taieb Frédéric , Bouchenot Catherine , Hashim Saleha , Tadrist Soraya , Lippi Yannick , Mirey Gladys , Vignard Julien 
Published: February 2021

Abstract
The Cytolethal Distending Toxin (CDT) is a bacterial genotoxin produced by pathogenic bacteria causing major foodborne diseases worldwide. CDT activates the DNA damage response and induces inflammatory signatures in host cells, but the precise relationship between these outcomes has not been addressed so far. Here, we show that the cellular proinflammatory response and senescence induced by CDT depend on the cytoplasmic DNA sensor cGAS through the recognition of micronuclei. Indeed, despite active cell cycle checkpoints and in contrast to other DNA damaging agents, cells exposed to CDT reach mitosis where they accumulate massive DNA damage, resulting in chromosome fragmentation and micronucleus formation in daughter cells. These phenotypes are observed with CDT from various origins and in cancer or normal cell lines. Thus, our results establish a direct link between CDT-induced DNA damage, genetic instability and the cellular inflammatory response that may be relevant in the context of natural infection associated to chronic inflammation or carcinogenesis.
Whole Exome Sequencing Revealed a Novel Sequence Variant in The OTULIN Underlying Auto-Inflammatory Syndrome
Authors: Raza Rubab , Jimenez-Heredia Raul , Anwar Muhammad Zeeshan , Ullah Asmat , Zia Ayisha , Rashid Sajid , Ahmad Wasim , Krolo Ana , Boztug Kaan , Raza Irfan 
Published: February 2021

Abstract
Purpose Systemic auto-inflammatory diseases are a diverse group of heterogeneous disorders resulting in development of the systemic inflammation in absence of the inflammatory induction. Sequence variants in the OTULIN gene, which disrupts its ubiquitination activity lead to auto-inflammation, panniculitis, and dermatosis syndrome. To date, only few disease-causing variants in the OTULIN have been reported.In the study, presented here, sequence analysis of the OTULIN gene in a patient, exhibiting features of OTULIN-related auto-inflammatory syndrome (ORAS), revealed a novel disease-causing missense variant p.(Thr312Met). Further, effect of the variant on structure and function of the OTULIN protein has been examined using in silico OTULINWT and OTULINT312M. Methods Cells, collected from the patient blood, were examined by flow cytometry. Search for the disease-causing variants was carried out using exome followed by Sanger sequencing. Effect of the sequence variant on structure of the mutated protein was studied using in-silico analyses. Results Flow cytometry analysis revealed slightly reduced number of lymphocytes, marked leukocytosis, and mildly increased levels of IgG. Whole exome sequencing coupled with Sanger sequencing revealed a homozygous missense variant [c.935C>T; p.(Thr312Met)] in the OTULIN gene. In-silico analyses revealed that the missense variant reduces OTULIN’s expression and promotes accumulation of LUBAC-linked UB chains leading to auto-inflammation.Conclusion Taken together, OTULIN may act as a novel therapeutic target for the development of immunomodulatory drugs that may potentially increase or stabilize their expression. Targeting more components of the Ub-proteasome pathway may provide new opportunities for therapeutic exploitation and drug discovery.