bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history
Authors: Ide Hiroki , Kikuchi Eiji , Ogihara Koichiro , Niwa Naoya , Shigeta Keisuke , Masuda Tsukasa , Baba Yuto , Mizuno Ryuichi , Oya Mototsugu 
Published: October 2021

AbstractLimited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed to identify independent predictors of UTUC recurrence in all patients and those with a smoking history. Our study population comprised 1190 NMIBC patients who underwent transurethral resection of bladder tumor. UTUC developed in 43 patients during the follow-up. A history of bacillus Calmette-Guérin (BCG) therapy was independently associated with a lower incidence of UTUC (HR = 0.43; P = 0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH (< 6) were independently associated with a higher incidence of UTUC recurrence (HR = 3.34, P = 0.006 and HR = 3.73, P = 0.008, respectively). Among patients with a longer smoking duration (≥ 20 years) or larger smoking intensity (≥ 20 cigarettes per day), those with lower urinary pH (< 6) had a significantly higher UTUC recurrence rate than their counterparts. These results suggest that BCG instillation may prevent UTUC recurrence in NMIBC patients, while a lower urinary pH and concomitant CIS increase the risk of UTUC recurrence in those with a smoking history.
Population dynamics of the sea snake Emydocephalus annulatus (Elapidae, Hydrophiinae)
Authors: Shine Richard , Brown Gregory P. , Goiran Claire 
Published: October 2021

AbstractFor sea snakes as for many types of animals, long-term studies on population biology are rare and hence, we do not understand the degree to which annual variation in population sizes is driven by density-dependent regulation versus by stochastic abiotic factors. We monitored three populations of turtle-headed sea snakes (Emydocephalus annulatus) in New Caledonia over an 18-year period. Annual recruitment (% change in numbers) showed negative density-dependence: that is, recruitment increased when population densities were low, and decreased when densities were high. Windy weather during winter increased survival of neonates, perhaps by shielding them from predation; but those same weather conditions reduced body condition and the reproductive output of adult snakes. The role for density-dependence in annual dynamics of these populations is consistent with the slow, K-selected life-history attributes of the species; and the influence of weather conditions on reproductive output suggests that females adjust their allocation to reproduction based on food availability during vitellogenesis.
Influence of moon and clouds on night illumination in two different spectral ranges
Authors: Krieg Jürgen 
Published: October 2021

AbstractThe variable brightness of the night sky affects plants as well as animals and humans. However, knowledge about this variability is still insufficient. Outstanding questions regarding how significant the influence of the moon, clouds, and artificial lighting remain. To be able to make statements about these effects, measurements over a long period of time are necessary. Fraunhofer IOSB performs such measurements in the 380–780 nm photopic visual and 800–1700 nm shortwave infrared spectral range. As the latter is only marginally affected by artificial lighting, a comparison of the two bands deepens insight into the influence of artificial lighting. First analyses show that the moon is, as expected, the dominant light source in the night sky, especially during a full moon. Illuminance values up to 200 mlx and irradiance values up to 600 µW/m2 were measured in the visible and infrared respectively. The influence of clouds is more complicated. The measured intensities depend, among other things, on cloud cover and cloud altitude. When the night sky is overcast, the measured intensities can drop as low as 0.5 mlx and 0.5 µW/m2, respectively. These small values were measured during rainfall. The influence of artificial illumination is difficult to estimate, as intensities in the shortwave infrared decrease with increasing cloud cover, but increase in the visual.
Validation of the optical Aktiia bracelet in different body positions for the persistent monitoring of blood pressure
Authors: Sola Josep , Vybornova Anna , Fallet Sibylle , Polychronopoulou Erietta , Wurzner-Ghajarzadeh Arlene , Wuerzner Gregoire 
Published: October 2021

AbstractThe diagnosis of hypertension and the adjustment of antihypertensive drugs are evolving from isolated measurements performed at the physician offices to the full phenotyping of patients in real-life conditions. Indeed, the strongest predictor of cardiovascular risk comes from night measurements. The aim of this study was to demonstrate that a wearable device (the Aktiia Bracelet) can accurately estimate BP in the most common body positions of daily life and thus become a candidate solution for the BP phenotyping of patients. We recruited 91 patients with BP ranging from low to hypertensive levels and compared BP values from the Aktiia Bracelet against auscultatory reference values for 4 weeks according to an extended ISO 81060-2 protocol. After initializing on day one, the observed means and standard deviations of differences for systolic BP were of 0.46 ± 7.75 mmHg in the sitting position, − 2.44 ± 10.15 mmHg in the lying, − 3.02 ± 6.10 mmHg in the sitting with the device on the lap, and − 0.62 ± 12.51 mmHg in the standing position. Differences for diastolic BP readings were respectively of 0.39 ± 6.86 mmHg, − 1.93 ± 7.65 mmHg, − 4.22 ± 6.56 mmHg and − 4.85 ± 9.11 mmHg. This study demonstrates that a wearable device can accurately estimate BP in the most common body positions compared to auscultation, although precision varies across positions. While wearable persistent BP monitors have the potential to facilitate the identification of individual BP phenotypes at scale, their prognostic value for cardiovascular events and its association with target organ damage will need cross-sectional and longitudinal studies. Deploying this technology at a community level may be also useful to drive public health interventions against the epidemy of hypertension.
A numerical study on the closed packed array of gold discs as an efficient dual mode plasmonic tweezers
Authors: Aqhili Abolfazl , Darbari Sara 
Published: October 2021

AbstractIn this report, we propose the closed pack array of gold discs on glass, as a dual mode plasmonic tweezers that benefits from two trapping modes. The first trapping mode is based on leaky surface plasmon mode (LSPM) on the gold discs with a longer penetration depth in the water and a longer spatial trapping range, so that target nanoparticles with a radius of 100 nm can be attracted toward the gold surface from a vertical distance of about 2 µm. This trapping mode can help to overcome the inherent short range trapping challenge in the plasmonic tweezers. The second trapping mode is based on the dimer surface plasmonic mode (DSPM) in the nano-slits between the neighboring gold discs, leading to isolated and strong trapping sites for nanoparticles smaller than 34 nm. The proposed plasmonic tweezers can be excited in both LSPM and DSPM modes by switching the incident wavelength, resulting in promising and complementary functionalities. In the proposed plasmonic tweezers, we can attract the target particles towards the gold surface by LSPM gradient force, and trap them within a wide half widthhalfmaximum (HWHM) that allows studying the interactions between the trapped particles, due to their spatial proximity. Then, by switching to the DSPM trapping mode, we can rearrange the particles in a periodic pattern of isolated and stiff traps. The proposed plasmonic structure and the presented study opens a new insight for realizing efficient, dual-mode tweezers with complementary characteristics, suitable for manipulation of nanoparticles. Our thermal simulations demonstrate that the thermal-induced forces does not interefe with the proposed plasmonic tweezing.
Structural and functional analysis of Hydra Actinoporin-Like Toxin 1 (HALT-1)
Authors: Ker De-Sheng , Sha Hong Xi , Jonet Mohd Anuar , Hwang Jung Shan , Ng Chyan Leong 
Published: October 2021

AbstractActinoporins are a family of α-pore-forming toxins (α-PFTs) that have been identified in sea anemones. Recently, a freshwater Hydra Actinoporin-Like Toxin (HALT) gene family was found in Hydra magnipapillata. Unlike sea anemone actinoporins that use sphingomyelin as their main recognition target, the HALTs proteins may recognise alternative lipid molecules as their target. To unveil the structural insights into lipid preference of HALTs protein as compared to sea anemone actinoporins, we have determined the first crystal structure of actinoporin-like toxin, HALT-1 at 1.43 Å resolution with an acetylated lysine residue K76. Despite the overall structure of HALT-1 sharing a high structural similarity to sea anemone actinoporins, the atomic resolution structure revealed several unique structural features of HALT-1 that may influence the lipid preference and oligomerisation interface. The HALT-1 contains a RAG motif in place of the highly conserved RGD motif found in sea anemone actinoporins. The RAG motif contributed to a sharper β9-β10 turn, which may sway its oligomerisation interface in comparison to sea anemone actinoporins. In the lipid-binding region, the HALT-1 contains a shorter α2 helix and a longer α2-β9 loop due to deletion and subsequently an insertion of five amino acid residues in comparison to the sea anemone actinoporins. Structure comparison and molecular docking analysis further revealed that the HALT-1 lipid-binding site may favour sphingolipids with sulfate or phosphate head group more than the sphingomyelin. The structure of HALT-1 reported here provides a new insight for a better understanding of the evolution and lipid recognition mechanism of actinoporin.
Synthesis of ultra-stable perovskite composite quantum dots for light-emitting diodes
Authors: Bao Zhen , Chang Yu-Chun , Wang Hung-Chia , Lee Yu-Chun , Tsai Tzong-Liang , Liu Ru-Shi 
Published: October 2021

We successfully optimized a simple process without using any solvents for synthesizing an ultra-stable CsPbBr3@SiO2 luminescent material. The achieved CsPbBr3@SiO2 showed ultra-high stability for LED application.
State solutions for distribution systems and switching event using a neural network
Authors: Yaniv Arbel , Lin Avi , Raz David , Beck Yuval 
Published: October 2021

AbstractPower flow calculations are an essential stage in many planning and control applications for distribution systems.To use these in control applications, however, the calculation time needs to be improved, and this can be done by the use of a trained ANN. This paper presents the considerations for constructing ANNs for DSs, and describes a method for training the system in order to support switching events representing a change in topology. The solutions for three DSs, balanced as well as unbalanced, are presented and the various considerations affecting the most appropriate ANN construction are discussed. The results are compared to the solution from the classical complex Newton‐Raphson and the fixed‐point iterative methods. The solutions have very high precision and good results are found for switched laterals. The computational performance is also compared and an improvement of two orders of magnitude is observed.
Ernährungsteams in hessischen Akutkrankenhäusern
Authors: Hahn Sigrid Ursula , Ferschke Melanie 
Published: October 2021

ZusammenfassungMangel- und Fehlernährung spielt in Krankenhäusern nach wie vor eine große Rolle. Multidisziplinäre Ernährungsteams, die sich aus Medizinern, Ernährungstherapeuten (Diätassistenten, Oecotrophologen oder Ernährungswissenschaftlern), Pflegkräften und gegebenenfalls weiteren Berufsgruppen wie Pharmazeuten, Mitarbeiter aus der Küche, Logopäden etc. zusammensetzen, bieten die Chance Ernährungsprobleme frühzeitig zu erkennen und zu therapieren. Daher wird die Etablierung solcher Teams seit Jahren gefordert. Bislang fehlen allerdings Daten, die die Versorgung von Krankenhäusern in Deutschland mit Ernährungsteams aufzeigen und auch über die tatsächliche Zusammensetzung und Aufgaben der Teams fehlen Informationen. Ziel der vorliegenden Arbeit war es daher, in einer Pilotstudie die Situation in hessischen Akutkrankenhäusern zu erfassen. Es wurde ein Fragebogen als Onlineerhebungstool entwickelt, mit dem die Ausstattung der Häuser mit Ernährungsteams, die Zusammensetzung der Teams und ihre Aufgaben sowie Informationen zur Finanzierung des Supports erhoben wurden. Es wurden 127 Kliniken angeschrieben. An der Studie nahmen 12 Kliniken teil. Acht Häuser verfügen über ein Ernährungsteam. Die Zusammensetzung der Teams ist unterschiedlich und entspricht nicht den Leitlinien der DGEM. Aufgabenschwerpunkt sind: Mangelernährung, Versorgung nach großen chirurgischen Eingriffen, enterale und parenterale Ernährung, Lebensmittelunverträglichkeiten. Die Bedeutung der Ernährungsteams wird insbesondere in der Verbesserung der Ernährungsversorgung und einer damit einhergehenden verbesserten Lebensqualität gesehen. Insgesamt weist die Studie auf eine unzureichende Versorgung hessischer Akutkliniken mit Ernährungsteams hin. Eine bundesweite Erhebung zum Ernährungssupport in deutschen Krankenhäusern ist dringend erforderlich.
Effects of Capsiate Supplementation on Maximal Voluntary Contraction
in Healthy Men
Authors: dos Santos Gomes Willemax , de Freitas Marcelo Conrado , Dutra Yago Medeiros , Rossi Fabrício , Estanislau Thiago Barros , Gonçalves Daniela Caetano , Campos Eduardo Zapaterra 
Published: October 2021

AbstractThis study aimed to investigate the effects of acute capsaicin analog (Capsiate -
CAP) supplementation on maximal voluntary isometric contraction (MVIC)
performance in healthy young men. Thirteen subjects (25.2±3.2 yrs)
participated in the present study. In two different days separated by one week,
the subjects ingested capsiate (12 mg) or placebo (starch: 12 mg) 45 minutes
before a MVIC test. The MVIC test consisted of five 10-second knee extension
maximal isometric contractions with 45 seconds of recovery between efforts. The
peak force, mean force, minimum force, fatigue index, and area under the curve
of each contraction were calculated. Main condition effect was found, with
higher values of peak force (+4.83%, F=6.867,
p=0.02), fatigue index (+8.96%, F=5.228,
p=0.041), and area under the curve (+4.19%,
F=4.774, p=0.04) for CAP compared to placebo, however, no
interaction effect was found for any variable (F=0.090 to 1.356,
p≥0.276). In summary, healthy young men produced higher maximal
isometric force and delayed fatigue in the CAP condition compared to placebo
condition (condition effect) but without significant difference between each
effort.
Comparison of Sodium Lactate Infusion and Carbon Dioxide Inhalation Panic Provocation Tests: A Meta-analysis
Authors: Tural Umit , Iosifescu Dan V. 
Published: October 2021

AbstractBackground Sodium lactate (NaL) infusion and carbon dioxide (CO2) inhalation are proven to provoke acute panic attacks (PAs) in patients with panic disorder (PD). A systematic literature search and meta-analysis were performed to compare the effect sizes of these methods.Methods Odds ratios were calculated for each of the original studies and were pooled using the random-effects model.Results Either NaL or CO2 provocations significantly increased the rates of PAs in individuals with PD compared to those in healthy controls. However, the effect size of NaL infusion (OR=25.13, 95% CI=15.48–40.80) was significantly greater than that of CO2 inhalation (OR=10.58, 95%CI=7.88–14.21).Conclusion The evidence for the efficacy of the two panic provocation tests is very strong. Yet, the results support the superiority of NaL infusion over CO2 inhalation challenge as a panic provocation test. Thus, lactate seems a much stronger stimulus than CO2 for the brain suffocation detector.
Non–Vitamin K Antagonist Oral Anticoagulants in Coronary Artery Disease
Authors: Al Said Samer , Ellscheid Michael , Beltsios Eleftherios T. , Frey Norbert 
Published: October 2021

AbstractThe prevention of atherothrombotic events is the primary goal in the treatment of patients with arteriosclerotic disorders. Despite recent improvements in the management of coronary artery disease (CAD) with revascularization techniques and antiplatelet therapy, some patients remain at risk of recurrent cardiovascular events. This could be related to additional thrombin generation. As a result, there has been interest in developing novel therapies to prevent thromboembolic events, targeting thrombin-mediated pathways. These include non–vitamin K antagonist oral anticoagulants (NOACs). This article aims to summarize the recent clinical studies that investigated the role of NOACs in CAD.
Die Prophylaxe einer Endoleckage Typ II ist relevant für den
Langzeiterfolg von EVAR
Authors: Tenholt Matthias 
Published: October 2021

ZusammenfassungEiner von 8 Patienten benötigt nach endovaskulärer Ausschaltung eines infrarenalen
Bauchaortenaneurysmas (EVAR) eine Reintervention während der ersten 5 Jahre. Zwei Drittel der
Reeingriffe zielen darauf ab, Endoleckagen zu behandeln. Die Prävalenz von Komplikationen
verdoppelt sich im Fall von Endoleckagen. Stentprothesen der 4. Generation führen nicht zu
einer Abnahme Typ-2-assoziierter Reinterventionen, aber zu einer besseren Typ-I- und
-III-Endoleckage-Prävention. Die Vorbehandlung potenzieller Typ-II-induzierender Arterien mit
Embolisation und die Thrombusinduktion im Aneurysmasack werden diskutiert mit Hinblick auf
eine primäre Prophylaxe späterer Typ-II-Endoleckagen.
Ventralhernienversorgung in endoskopischer total extraperitonealer Technik (eTEP) – Evaluation der postoperativen Ergebnisse und des 1-Jahres-Follow-ups
Authors: Bauer Katrin , Heinzelmann Frank , Büchler Peter , Mück Björn 
Published: October 2021

Zusammenfassung
Hintergrund Mehrere in den letzten Jahren publizierte Metaanalysen zeigten, dass der Retromuskulärraum die bevorzugte Netzposition in der Versorgung von Ventralhernien ist. Operationen mit retromuskulärer Netzplatzierung wurde bislang hauptsächlich offen durchgeführt. In den letzten Jahren wurden neue minimalinvasive Verfahren mit total extraperitonealem Zugang und retromuskulärer Netzeinlage beschrieben.
Methoden Von September 2018 bis März 2019 wurden 18 Patienten endoskopisch in total extraperitonealer Technik an einer Ventralhernie operiert. In Abhängigkeit der Hernienlokalisation und -größe wurden verschiedene extraperitoneale Zugangswege gewählt und bei allen Patienten ein unbeschichtetes Netz im Retromuskulärraum platziert. Patientencharakteristika, peri- und postoperative Parameter wurden erhoben. Mithilfe des Herniamed-Fragebogens wurden die Patienten 1 Jahr nach Operation nach Rezidiv, Komplikationen und Schmerzen befragt.
Ergebnisse Intraoperative Komplikationen traten nicht auf. Postoperativ wurden ein nicht behandlungsbedürftiges Serom im Bereich des Netzlagers, eine passagere Radialisparese und eine Lungenembolie beobachtet, die alle ohne Langzeitfolgen für die Patienten blieben. 17 von 18 Patienten konnten nachverfolgt werden. Im 1-Jahres-Follow-up zeigte sich kein Hernienrezidiv. Ein Patient hatte behandlungsbedürftige Schmerzen in Ruhe.
Schlussfolgerung: Die total extraperitoneale eTEP-Technik ist eine neue vielversprechende Operationsmethode, mit der sich auch komplexe Ventralhernien mit akzeptablem 1-Jahres-Ergebnis versorgen lassen. Durch diese Technik lassen sich die Vorteile der minimalinvasiven Chirurgie mit denen der extraperitonealen Netzplatzierung kombinieren.
Epidemiology of Injuries in Olympic Sports
Authors: Lambert Christophe , Ritzmann Ramona , Akoto Ralph , Lambert Maxime , Pfeiffer Thomas , Wolfarth Bernd , Lachmann Daniel , Shafizadeh Sven 
Published: October 2021

AbstractInjuries effect the performance of athletes. Severity of injuries is determined
by time loss and sporting performance reduction. To treat injuries adequately,
it is necessary to get an overview of varied injuries types in different sports
disciplines. In a retrospective study 7.809 athletes from Germany, Switzerland
and Austria competing in competitive or recreational levels of sports were
included. Injury prevalence was highest in team sports (75%), followed
by combat (64%), racquet (54%) and track and field
(51%). Knee (28%) and shoulder (14%) were the most at
risk joints. Time loss in sporting activity after injury was longest in the
region of knee (26 weeks). Of all reported injuries, 48% were
accompanied by a reduced level of performance. The highest injury prevalence
occurred in the year 2016 (45%). More injuries occurred during training
(58%) compared to competition (42%). Across Olympic disciplines,
a large number of injuries occurred during training sessions. Injury frequency
increased as the Olympic games drew closer. Knee and shoulder injuries were the
most severe injuries with respect to time loss and reduction sporting
performance.
Aorta ascendens und Arcus aortae – endovaskuläre Therapie heute und in der Zukunft
Authors: Stana Jan , Peterß Sven , Prendes Carlota Fernandez , Stavroulakis Konsantinos , Rantner Barbara , Pichlmaier Maximilian , Tsilimparis Nikolaos 
Published: October 2021

ZusammenfassungPathologien im Bereich des Aortenbogens können isoliert auftreten, weit häufiger jedoch sind auch benachbarte Abschnitte der thorakalen Aorta – die Aorta ascendens oder Aorta descendens – mit betroffen. Die ersten operativen Eingriffe zur Behandlung des Aortenbogens wurden vor knapp 6 Jahrzehnten vorgenommen. Trotz zahlreicher Verbesserungen und Innovationen während des 20. und Anfang des 21. Jahrhunderts bleiben diese Eingriffe mit einer relevanten operativen Mortalität und neurologischen Komplikationsrate vergesellschaftet. Endovaskuläre Techniken sowie moderne Hybridverfahren erweitern das therapeutische Spektrum im Bereich des Aortenbogens zunehmend, auch wenn das offene operative Vorgehen aktuell noch der Goldstandard ist. Die endovaskuläre Behandlung eines Aortenaneurysmas wurde erstmals im Bereich der infrarenalen Aorta abdominalis in den frühen 1990er-Jahren durchgeführt. Es dauerte nicht lange, bis die ersten endovaskulären Therapieversuche zur Behandlung des
Aortenbogens unternommen wurden. Schon 1996 berichteten Inoue et al. über den Einsatz der ersten gebranchten Endoprothese zur Behandlung von Aneurysmen im Aortenbogen. Fortwährende Verbesserungen und Verfeinerungen der Implantationstechniken und auch des implantierten Materials führten dazu, dass heutzutage im Bereich der deszendierenden thorakalen und abdominellen Aorta die endovaskuläre Therapie eine immer bedeutsamere Option im Vergleich zu den offenen chirurgischen Verfahren darstellt und diese teils als Goldstandard abgelöst hat. Diese Übersichtsarbeit soll einen Überblick über Voraussetzungen, Ergebnisse, aber auch Grenzen der endovaskulären Chirurgie des Aortenbogens geben.