bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does strawberry supplementation ameliorate markers of cardiovascular and metabolic health? A systematic review and meta-analysis
Authors: Mousavi Reihaneh , Arab-Zozani Morteza , Foroumandi Elaheh , Karandish Majid , Maghsoumi-Norouzabad Leila , Mansoori Anahita , Moludi Jalal 
Published: December 2021

Purpose
This study aims to identify the effect of strawberry supplementation on some metabolic, inflammatory and oxidative parameters in adults with cardiovascular (CV) risk factors.

Design/methodology/approach
A systematic literature search was performed up to November 2020 using PubMed, Embase, Cochrane, Web of Sciences and Scopus databases. The pooled mean difference (MD) with 95% confidence interval (CI) was used to analyze the data by random-effects model. I2 statistics and Cochrane risk of bias tool were used for investigating heterogeneity and quality of included studies, respectively.

Findings
In total, 13 randomized controlled trials with 488 participants were included. Strawberry supplementation significantly reduced diastolic blood pressure (MD = −2.1, 95% CI [−3.7, −0.42], P = 0.01), low-density lipoprotein cholesterol (−0.16, −0.30, −0.02, P = 0.03), high-sensitivity C-reactive protein (CRP) (−0.76, −1.4, −0.05, P < 0.001) and CRP (−0.31, −0.43, −0.18, P = 0.04). Leptin levels were raised in control group compared with participants who had received strawberry (0.65, 0.09 and 1.2, P = 0.02). The results of subgroup analysis based on the follow-up duration and supplementation dose showed that consumption of strawberry for more than eight weeks and 50 g day−1 can significantly decrease some other CV risk factors compared to control group. Further, both higher follow-up duration and supplementation dose were more effective in increasing leptin levels of control group compared to intervention group.

Originality/value
The use of some useful plant foods such as strawberries by the pharmaceutical industry and the community health sector can greatly help improve people’s CV and metabolic health.
Social media usage and employee creativity: is relational energy a missing link?
Authors: Zhou Fei , Mou Jian , Wang Wei , Wu Yenchun Jim 
Published: December 2021

PurposePrevious studies overemphasize the negative effects of social media usage (SMU) within organizations and underestimate its positive influences on employees' behavior. This study attempts to link employees' social media use at work to their creativity performance.Design/methodology/approachBased on the bounded generalized reciprocity theory and unbounded indirect reciprocity (UIR) theory, the authors developed a research model. To test the model, the authors collected a set of 172 paired data of organizations and employees from 31 knowledge-intensive enterprises in China to test the hypothesis.FindingsThis research found that the social, cognitive and hedonic uses of social media all directly affect employee creativity. Relational energy fully mediates the effects of the cognitive and hedonic usages on creativity. Moreover, job autonomy moderates the effects of the relationships among the social, cognitive and hedonic uses on employee creativity.Originality/valueThe conclusions not only enriched authors’ understanding of the effectiveness of interpersonal interaction but also extended the research boundary of the relationship between SMU and employee creativity.
Microbial diversity and function in crystalline basement beneath the Deccan Traps explored in a 3 km borehole at Koyna, western India
Authors: Sahu Rajendra Prasad , Kazy Sufia K. , Bose Himadri , Mandal Sunanda , Dutta Avishek , Saha Anumeha , Roy Sukanta , Dutta Gupta Srimanti , Mukherjee Abhijit , Sar Pinaki 
Published: December 2021

SummaryDeep terrestrial subsurface represents a huge repository of global prokaryotic biomass. Given its vastness and importance, microbial life within the deep subsurface continental crust remains under‐represented in global studies. We characterize the microbial communities of deep, extreme and oligotrophic realm hosted by crystalline Archaean granitic rocks underneath the Deccan Traps, through sampling via 3000 m deep scientific borehole at Koyna, India through metagenomics, amplicon sequencing and cultivation‐based analyses. Gene sequences 16S rRNA (7.37 × 106) show considerable bacterial diversity and the existence of a core microbiome (5724 operational taxonomic units conserved out of a total 118,064 OTUs) across the depths. Relative abundance of different taxa of core microbiome varies with depth in response to prevailing lithology and geochemistry. Co‐occurrence network analysis and cultivation attempt to elucidate close interactions among autotrophic and organotrophic bacteria. Shotgun metagenomics reveals a major role of autotrophic carbon fixation via the Wood–Ljungdahl pathway and genes responsible for energy and carbon metabolism. Deeper analysis suggests the existence of an ‘acetate switch’, coordinating biosynthesis and cellular homeostasis. We conclude that the microbial life in the nutrient‐ and energy‐limited deep granitic crust is constrained by the depth and managed by a few core members via a close interplay between autotrophy and organotrophy.
A thermophile Hydrogenibacillus sp. strain efficiently degrades environmental pollutants polycyclic aromatic hydrocarbons
Authors: Qiu Xiaoyu , Wang Weiwei , Zhang Lige , Guo Lihua , Xu Ping , Tang Hongzhi 
Published: December 2021

SummaryPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants threatening ecosystems and human health. Here, we isolated and characterized a new strain, Hydrogenibacillus sp. N12, which is a thermophilic PAH‐degrader. Strain N12 utilizes naphthalene as a sole carbon and energy source above 60°C and co‐metabolizes many other PAHs as well. The metabolites were identified in the catabolism of naphthalene by gas chromatography–mass spectrometry (GC–MS) and stable isotopic analysis. Based on the identified metabolites, we proposed two possible metabolic pathways, one via salicylic acid and the other via phthalic acid. Whole‐genome sequencing reveals that strain N12 possesses a small chromosome of 2.6 Mb. Combining genetic and transcriptional information, we reveal a new gene cluster for the naphthalene degradation. The genes, designated as narAaAb that are predicted to encode the alpha and beta subunits of naphthalene dioxygenase, were subsequently subcloned into Escherichia coli and the enzyme activity was detected by whole‐cell transformation. Capacity to degrade several other tricyclic‐PAHs was also characterized, suggesting co‐existence of other constitutively expressed enzyme systems in strain N12 in addition to the naphthalene degradation gene cluster. Our study provides insights into the potential of the thermophilic PAH‐degrader in biotechnology and environmental management applications.
A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis
Authors: Min Xue , Cai Meng‐yun , Shao Tong , Xu Zi‐yang , Liao Zhaofu , Liu Dong‐liang , Zhou Meng‐yuan , Wu Wei‐peng , Zhou Yu‐lan , Mo Miao‐hua , Xu Shun , Liu Xinguang , Xiong Xing‐dong 
Published: December 2021

AbstractCircular RNAs (circRNAs) have been established to be involved in numerous processes in the human genome, but their function in vascular aging remains largely unknown. In this study, we aimed to characterize and analyze the function of a circular intronic RNA, ciPVT1, in endothelial cell senescence. We observed significant downregulation of ciPVT1 in senescent endothelial cells. In proliferating endothelial cells, ciPVT1 knockdown induced a premature senescence‐like phenotype, inhibited proliferation, and led to an impairment in angiogenesis. An in vivo angiogenic plug assay revealed that ciPVT1 silencing significantly inhibited endothelial tube formation and decreased hemoglobin content. Conversely, overexpression of ciPVT1 in old endothelial cells delayed senescence, promoted proliferation, and increased angiogenic activity. Mechanistic studies revealed that ciPVT1 can sponge miR‐24‐3p to upregulate the expression of CDK4, resulting in enhanced Rb phosphorylation. Moreover, enforced expression of ciPVT1 reversed the senescence induction effect of miR‐24‐3p in endothelial cells. In summary, the present study reveals a pivotal role for ciPVT1 in regulating endothelial cell senescence and may have important implications in the search of strategies to counteract the development of age‐associated vascular pathologies.
Profiling mentally ill offenders in Hong Kong: A 10‐year retrospective review study
Authors: Siu Bonnie Wei Man , Lai Eric Shek Kin , Lam Jessica Pui Yan , Chan Clement , Chan Anita Wai Lan , Chu Kin Yan , Leong Sek Lim , Lui Sing Heung , Liu Amy Ching Yung , Tang Dorothy Yuen Yee , So Wai Lam , Leung Hon Wah , Mok Cycbie Ching Man , Lam Ming 
Published: December 2021

AbstractIntroductionThis study aimed to analyze the estimated prevalence of mental disorders among offenders and compare the estimated crime rate between mentally ill patients and the total population in Hong Kong.MethodsService data of offenders referred to psychiatrists at the Siu Lam Psychiatric Centre from January 2011 to December 2020 were analyzed. Demographic data of gender, age on admission, educational level, principal psychiatric diagnosis, index offense, and assessment outcome were collected.ResultsData of 7535 offenders (74.8% males) aged 14 to 97 (mean: 41.3 ± 13.7) years were analyzed. More than 60% (66.2%) had a diagnosable mental disorder. The most prevalent principal psychiatric diagnosis was schizophrenia and related disorder (22.8%), followed by mental and behavioral disorders due to psychoactive substance use (18.6%), and mood disorders (8.8%). The commonest index offenses were theft and related offenses (20.5%), followed by acts intended to cause injury (19.7%), and illicit drug offenses (11.6%). The estimated prevalence of mental illness among prison population was 7.1% (male: 8.2%, female: 5.0%). The estimated crime rate for mentally ill patients was found to be 43.3 to 263.2 per 100 000 population.DiscussionThe estimated prevalence of mental disorders among offenders and the estimated crime rate for mentally ill patients are relatively low in Hong Kong. The result was an important effort to document the changing characteristics of mentally ill offenders and provide an estimation of the prevalence and crime rate for mentally ill patients in Hong Kong.
Acute antibiotically induced neutropenia: A systematic review of case reports
Authors: Holz Julian M. , Chevtchenko Alon V. , Aitullina Aleksandra 
Published: December 2021

AimsAcute neutropenia induced by antibiotics is a rare side effect of this frequently prescribed class of drugs. We aim to find similarities and differences between reported cases.MethodsThrough a database search (PubMed, 1968–2020), we identified published case reports and extracted, among other data, patient demographics, duration of treatment with the respective agent, and duration of recovery.ResultsOverall, 83 cases were included. Neutropenia developed after a median (min–max) of 21 (17.5–28.5) days of treatment and was resolved after a median (min–max) of 6 (3.0–8.75) days. Vancomycin and ceftaroline emerged as the two most commonly described antibiotics. In 51.8% of cases, the suspected antibiotic was discontinued; in 37.4% of cases, it was substituted by another agent. Only three case reports mentioned death as a result of neutropenia. The use of granulocyte colony‐stimulating growth factors (CSFs) shortened the duration of neutropenia and improved outcome for patients' health.ConclusionNeutropenia induced by antibiotics remains a rare or rarely reported side effect. Long‐term and high‐dose treatment regimens expose a higher risk of development. Thus, regular full blood counts are advised during therapy.
Strategy implementation for the 2030 agenda: Insights from Brazilian companies
Authors: Cristina Ferreira Caldana Adriana , Marchiori Pacheco Larissa , Fernandes Rodrigues Alves Marlon , Henrique Paulino Pires Eustachio João , Bastos Fernandes dos Santos Neusa Maria 
Published: December 2021

AbstractWhile firms' engagement with Corporate Social Responsibility has been associated with positive performance impacts, little is known about the incorporation of the United Nations 2030 Agenda into business practices. Precisely, although the literature suggests that firms are pursuing the Sustainable Development Goals (SDGs), there are limited insights on their strategy to implement them in the context of developing countries. To address this gap, we conducted a comprehensive large‐scale investigation of 2030 Agenda adoption by Brazilian companies. Accordingly, the analysis of our multicase study reveals (1) variations on the business opportunities brought by the SDGs depending on the firm position in the value chain, (2) which SDGs and target stakeholders are addressed through corporate policies and practices, (3) the different ways firms embrace the SDGs to pursue ambidexterity. Our findings clarify how firms in the developing countries interpret the institutional pressures and assemble their internal resources to respond to the SDGs challenges. Boundary conditions and policy implications are further discussed.
Your pain is not mine: A critique of clinical empathy
Authors: Stefanello Eugenia 
Published: December 2021

AbstractBoth in mainstream culture and in bioethical literature, there is a general agreement on the absolute positive value assigned to empathy in healthcare settings. Thanks to its two components—affective and cognitive—clinical empathy should allow physicians to be emotionally affected by the experiences of their patients, and at the same time, to imagine their situations in order to gain a deeper understanding and implement a ‘tailored’ approach to care. So, it seems that good physician has become synonymous with empathetic physician. However, while acknowledging its numerous benefits, I will argue that clinical empathy seems to harbour some dark sides. First, the affective component of clinical empathy (i.e. emotional resonance) is responsible for its partial nature and can lead to cognitive and moral distortions. Moreover, it can lead healthcare providers to negative psychological states, such as burnout and personal distress. Second, the cognitive component of empathy can be problematic as well: perspective‐taking is a far more difficult task than it is ordinarily thought to be. I will also try to demonstrate that accessing the inner world of others is neither possible nor desirable since this operation can result in undermining the patient's agency. Third, clinical empathy can become a tool that disguises the power imbalance between patients and doctors, and this can reinforce an elitist and paternalistic conception of the clinical encounter. Furthermore, the disregard for the influence that the sociocultural context has on the clinical relationship can amplify and promote instances of epistemic injustice perpetuating discriminatory and unfair dynamics.
A proposed community caries index of treatment need derived from the international caries detection and assessment system
Authors: ElSalhy Mohamed , Alsumait Aishah , Behzadi Sahar , Lai Hollis , Almerich‐Silla José Manuel , Piovesan Chaiana , Flores‐Mir Carlos , Amin Maryam 
Published: December 2021

AbstractObjectiveTo examine the accuracy of a short version of the International Caries Detection and Assessment System (ICDAS) in predicting caries treatment need for children.MethodsThe study is a validation study using data from three previously published cross‐sectional studies. Participants were children with different dentitions from Kuwait, Brazil, and Spain. Children were clinically examined using ICDAS criteria. Children were classified into preventive, non‐operative, and operative categories. Sensitivity and specificity, predictive values, likelihood ratios, and the area under the receiver operating characteristic (ROC) curve were used to measure the discriminative and diagnostic accuracy of the proposed short version of ICDAS compared to the full ICDAS.ResultsClinical dental examination data from a total of 3076 children aged 1–15 years were used. The proposed short ICDAS and the full ICDAS showed a very good agreement on caries treatment need determination with Kappa scores of more than 0.833 in all dentitions. The short ICDAS showed excellent operating characteristics in all dentitions. The area under the ROC was more than 90% in primary dentition, 89% in permanent dentition, and 86% in mixed dentition in different populations. Lowest area under ROC and sensitivity values were observed when discriminating between non‐operative and operative treatment categories.ConclusionsThe proposed short version of the ICDAS showed good diagnostic accuracy in classifying children according to their caries treatment need. By reducing the number of surfaces examined and the time needed for clinical assessment, the short version of the ICDAS is a convenient alternative to the full ICDAS to be used in community settings.
The influence of different forms of sinus membrane perforation on the prevalence of postoperative complications in lateral window sinus floor elevation: A retrospective study
Authors: Krennmair Stefan , Weinländer Michael , Forstner Thomas , Malek Michael , Krennmair Gerald , Postl Lukas 
Published: December 2021

AbstractBackgroundMaxillary sinus membrane perforation (SMP) during lateral window sinus floor elevation (SFE) might be associated with postoperative complications (PC).ObjectivesTo evaluate the prevalence of PC and clinical implant outcome for different forms of SMP with lateral window SFE.Material and MethodsThe prevalence of PC such as maxillary sinusitis, graft necrosis and wound infection was retrospectively evaluated for 434 lateral window SFE (334 patients) with 331 SFE (241 patients) without and 103 SFE (93 patients) with SMP. SMP was additionally classified into four subgroups regarding to membrane perforation size (small‐moderate [<10 mm] vs. large [>10 mm]) and membrane biotype ([BT] thin vs. thick). Additionally, patient‐ and surgery‐related risk factors affecting PC and the 1‐year implant survival rate were evaluated for SFE without and with SMP and subgroups.ResultsA significantly higher prevalence including significant odds ratios of PC such as maxillary sinusitis (10/103 [9.7%] vs. 4/331 [1.2%]; p < 0.021; OR: 8.85; p < 0.021) and graft necrosis (7/103[6.8%] vs. 1/103[0.3%]; p < 0.017; OR:7.43; p < 0.017) was found for SFE with than without SMP. The SMP subgroup with large size and thin BT involved significantly (p < 0.005) more PC (15/20[75%]) than all other SMP subgroups (5/20[25%]). For the risk factors evaluated the univariate analysis demonstrated differences of PC for the presence versus absence of SMP (p < 0.001) and for thin versus thick sinus mucosa (p < 0.038; p < 0.006) but not for sex, smoking, sinus septa and surgical stage. In the multivariate risk factors analysis, PC were significantly related to risk factors such as large size with thin BT (OR:18.049; p < 0.007). The 1‐year implant survival rate did not differ between SFE without (99.5%) and with SMP (99.1%), regardless of successfully repaired subtype of SMP.ConclusionThe synopsis of perforation size and membrane biotype is crucial in differentiating different forms of SMP assessing and anticipating different prevalences of PC in lateral window SFE.
Open‐Mindedness and the (Un)Controversial in Classrooms
Authors: Papastephanou Marianna 
Published: December 2021

ABSTRACTEducational‐theoretical discussions of open‐mindedness and closed‐mindedness focus on the moral benefits and hazards of these dispositions in pedagogical encounters with the new and hitherto alien. Such discussions often employ spatial metaphors of openness and rely on politically safe examples to illustrate ambiguous enactments of open‐mindedness and closed‐mindedness as epistemic or moral virtues and vices. This article explores how a shift in our metaphors and a change in attention from the new to the “inflammatory (un)controversial” may complicate current outlooks on open‐mindedness and politicize it differently. To illustrate this critique of virtue‐theoretic approaches to open‐mindedness, the article uses fictive classroom exchanges on Holocaust and genocide denialism as (un)controversial material that ignites minds.
Between Simmel's Blasé Attitude and Intelligent Teachability
Authors: Gałkowski Stanisław , Kaźmierczak Paweł 
Published: December 2021

AbstractThe aim of this article is to explore Georg Simmel's concept of the blasé attitude and to contrast it with the notion of intelligent teachability, derived from Aristotelian–Thomistic tradition. Here, Stanisław Gałkowski and Paweł Kaźmierczak view these two accounts through the lens of contemporary virtue epistemology, which helps to demonstrate their relevance to present‐day educational theory, and to order the attitudes in question as intellectual counterparts of vice, akrasia, self‐control, and virtue. There are two main criteria for how to distinguish these four states: (1) motivation to have epistemic contact with reality, and (2) the proper balance between receptivity and autonomy in learning. Taking the formation of intellectual character to be an important educational goal, Gałkowski and Kaźmierczak highlight the role of the teacher as an exemplar of mental disposition.
Comparison of real‐time PCR tests for the detection of Synchytrium endobioticum resting spores in soil and their potential application in descheduling of previously infested plots
Authors: van de Vossenberg Bart T. L. H. , te Braak Naomi , Warbroek Tim , Meffert Johan P. , Rosendahl‐Peters Karin H. M. , van Gent‐Pelzer Marga P. E. , van Rijswick Patricia C. J. 
Published: December 2021

AbstractPlots infested with Synchytrium endobioticum, the causal agent of potato wart disease, are scheduled, resulting in prohibition of potato cultivation of and cultivation of plants for planting. On account of robust resting spores that are present in infested soils, plots remain scheduled for 20 years. After this period, plots are intensively sampled and the presence of resting spores in soil is determined by direct examination. However, this method is very time‐consuming and labour‐intensive. In this paper, validation data for the molecular detection of resting spores in soil and its use to screen soils before direct examination are reported. In addition to the samples in the validation study, over 670 routine diagnostic samples were analysed by direct examination and molecular tests in parallel. Using an improved methodology, increased sensitivity was obtained relative to results reported from an interlaboratory comparison study in 2018, namely 7 spores per sample instead of 500 spores per sample. Molecular screening of the soil samples and direct examination of those samples testing positive was estimated to reduce the total hands‐on time by half when compared to direct examination of all samples. We recommend inclusion of molecular detection in the update of EPPO PM 3/59 (3) and PM 7/28(2), and suggest that when all subsamples of a plot are negative, no additional direct examination or bio‐assays are needed for descheduling (i.e. for releasing previously infested plots from official control).