bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatic zoning for the building thermal design in China's rural areas
Authors: Chen Yao , Wang Zhiwei , Wei Peng 
Published: April 2021

Building climatic zoning is a prerequisite for implementing building energy efficiency technology, which can help code makers and architects have an accurate understanding of the local climatic conditions. It takes the extreme monthly average temperature as the zoning index in the existing climatic zoning of rural areas in China. There will be unreasonable design phenomena of insufficient or excessive thermal insulation for a building envelope in rural areas. Aiming at the above problems, this paper modifies the current zoning. This research established the cooling and heating degree-day indexes HDD14 and CDD30 based on the thermal comfort characteristics of rural occupants and used the threshold method to subdivide rural areas into eight sub-zones. The results show that the problem of insufficient or excessive thermal insulation in rural areas can be effectively solved by replacing the extreme monthly average temperature index with the degree day index and the annual cumulative building load can be reduced by 6.4% on average without increasing the insulation cost. After more detailed zoning, the variance within the group is reduced and it accurately describes climate diversity, which is conducive to implementing climate-responsive energy-saving design in each subzone. Practical application: The major purpose of this paper is to solve the problem of unreasonable climate zone boundaries specified in the existing Design Standard for Energy Efficiency of Rural Residential Buildings. The existing zoning has led to conflicts between the actual heating demand and the building envelope thermal parameter limits specified in the standard. This work redefines the boundaries of the existing map using more up-to-date weather data to provide the right guidance for architectural designers.
Do Health-Seeking Populations Know the Link Between Human Papillomavirus and Oropharyngeal Cancer? A Cross-Sectional Study in a Nigerian Population
Authors: Adesina Ayodele , Olufemi Erinoso , Oluwatosin Odukoya , Kayode Obigbesan , Babatunde Alli , Babalola Castano , Michael Gbotolorun 
Published: April 2021

Background The human papillomavirus (HPV) has been causally linked to oropharyngeal cancers. The extent to which the population is aware of this link has not been explored in Nigeria. We aim to investigate the knowledge of the link between HPV and oropharyngeal cancers in a health-seeking population in Nigeria. Methodology: We used a cross-sectional study design, with a multi-stage sampling method comprising a cluster of four health facilities and first-time adult patients attending the general outpatient clinics of the selected health facilities. An interviewer-administered questionnaire was be used to obtain demographic information, social history, HPV awareness, HPV vaccination and the link between HPV and oropharyngeal cancer. Results A total of 1,000 respondents completed the survey from four health facilities in Lagos, Nigeria. Majority of respondents were below 40 years (61.5%), and female (53.4%). About 13.4% of the study population were aware of HPV, and 7.9% of HPV vaccines. The most common source of HPV information for respondents who were aware of HPV was the internet (65.4%). Only 7.7% of respondents knew the link between HPV and oropharyngeal cancer. Significant predictors of knowledge of the link between HPV and oropharyngeal cancer were higher education [ p: 0.012], higher overall knowledge of HPV risk factors and complications [ p: 0.000]; and awareness of HPV vaccine [ p: 0.020]. Conclusions Our findings suggest a lack of public knowledge of the link between HPV and oropharyngeal cancer. These findings could inform health promotion measures for oropharyngeal cancer, particularly for groups where knowledge is lowest.
Exploring the Efficacy of Comprehensive Management of Breast Abscesses in Restoring Milk Volume
Authors: Haifeng Gao , Yi Zhang , Ying Chen , Xin Li , Yan Li , Songtao Ding , Yajun Gao , Xiangping He , Si Chen , Xingxing Liu 
Published: April 2021

Background Approximately 54.8% of patients with breast abscesses discontinue breastfeeding due to the lack of adequate breastfeeding support. Research aims We aimed to (1) examine the difference in milk volume produced by healthy breasts and breasts with abscesses; and (2) to explore the changes in milk volume before and after comprehensive management. Method A prospective, consecutive series study was designed. Lactating patients ( N = 50) with breast abscesses were selected from March 2017 to November 2018. The volume and frequency of milk expression of the affected and the unaffected breast were recorded every 24 hr before and after comprehensive management. The difference in the milk volume produced by healthy breasts (control) and breasts with abscesses, as well as the milk volume produced by each breast before and after comprehensive management, was determined. Results There was a significant difference in the milk volume produced by healthy breasts and breasts with abscess before ( t = 3.016; p = .004) and after ( t = 4.336; p < .001) comprehensive management. The frequency of milk expression was significantly higher after comprehensive management than before it ( z = −6.145; p < .001); the milk volume produced by each side significantly increased after comprehensive management (healthy breasts: t = −4.789; p < .001; breasts with abscess: t = 2.555; p = .014). Conclusion The total milk volume produced by breasts with abscesses can be less than that produced by healthy breasts. The management of abscesses by increasing the frequency of milk expression and degree of emptying can help mothers increase their milk volume.
COVID-19-Induced Anosmia and Ageusia Are Associated With Younger Age and Lower Blood Eosinophil Counts
Authors: Sehanobish Esha , Barbi Mali , Fong Valerie , Kravitz Meryl , Sanchez Tejera Denise , Asad Mohammad , Matsumura Cynthia , Ferastraoaru Denisa , O’Neill Meaghan , Karagic Merhunisa , Akbar Nadeem , Bottalico Danielle M. , Patel Viraj , Peshansky Alexandre , Rangareddy Mahendra , Hudes Golda , Kim Mimi , Eisenberg Ruth , Nath Avindra , Smith Bryan R. , Ow Thomas J. , Jerschow Elina 
Published: April 2021

Background Anosmia and ageusia are symptoms commonly associated with COVID-19, but the relationship with disease severity, onset and recovery are unclear. Objective To examine factors associated with anosmia and ageusia and the recovery from these symptoms in an ethnically diverse cohort. Methods Individuals tested for SARS-CoV-2 between March and April 2020 were eligible for the study. Randomly selected participants answered a telephone questionnaire on COVID-19 symptoms with a focus on anosmia and ageusia. Additionally, relevant past medical history and data on the COVID-19 clinical course were obtained from electronic medical records. 486 patients were in the COVID-19 group and 103 were COVID-19-negative. Results Patients who were younger were more likely to report anosmia and/or ageusia (odds ratio (OR) for anosmia per 1-year increase in age: 0·98, 95%CI:0–97-0·99, p = 0·003; for ageusia: 0·98, 95%CI:0·97-0·99, p = 0·005) as were patients with lower eosinophil counts (OR for anosmia per 0.1-K/μL increase in eosinophils: 0·02, 95%CI:0·001-0·46, p = 0·01, for ageusia 0·10, 95%CI:0·01-0·97, p = 0·047). Male gender was independently associated with a lower probability of ageusia (OR:0·56, 95%CI:0·38-0·82, p = 0·003) and earlier sense of taste recovery (HR:1·44, 95%CI:1·05-1·98, p = 0·02). Latinos showed earlier sense of taste recovery than white patients (HR:1·82, 95%CI:1·05-3·18, p = 0·03). Conclusion Anosmia and ageusia were more common among younger patients and those with lower blood eosinophil counts. Ageusia was less commonly reported among men, and time to taste recovery was earlier among both men and Latinos.
Parents’ experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence
Authors: Kimbell B. , Lawton J. , Boughton C. , Hovorka R. , Rankin D. 
Published: April 2021

Abstract
Aims
To synthesise the qualitative evidence on parents’ experiences of caring for a child aged ≤8 years with type 1 diabetes to identify: the challenges they encounter; their views about support received; ways in which support could be improved; and, directions for future research.

Methods
We searched Medline, EMBASE, CINAHL, PsycINFO and Web of Science databases to identify qualitative studies reporting parents’ views and experiences of caring for a child with type 1 diabetes aged ≤8 years. Key analytical themes were identified using thematic synthesis.

Results
Fourteen studies were included. The synthesis resulted in the generation of two overarching themes. Monopolisation of life describes the all-encompassing impact diabetes could have on parents due to the constant worry they experienced and the perceived need for vigilance. It describes how parents’ caring responsibilities could affect their wellbeing, relationships and finances, and how a lack of trusted sources of childcare and a desire to enable a ‘normal’ childhood constrained personal choices and activities. However, use of diabetes technologies could lessen some of these burdens. Experiences of professional and informal support describes how encounters with healthcare professionals, while generally perceived as helpful, could lead to frustration and anxiety, and how connecting with other parents caring for a child with type 1 diabetes provided valued emotional and practical support.

Conclusions
This synthesis outlines the challenges parents encounter, their views about support received and ways in which support might be improved. It also highlights significant limitations in the current literature and points to important areas for future research, including how sociodemographic factors and use of newer diabetes technologies influence parents’ diabetes management practices and experiences.
PROSPERO: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019128710
A large retroperitoneal lipoblastoma as an incidental finding: a case report
Authors: Gerhard-Hartmann Elena , Wiegering Verena , Benoit Clemens , Meyer Thomas , Rosenwald Andreas , Maurus Katja , Ernestus Karen 
Published: April 2021

Abstract
Background
Lipoblastoma is a rare benign mesenchymal neoplasm of infancy that most commonly occurs on the extremities and trunk but can arise at variable sites of the body. Retroperitoneal lipoblastomas are particularly rare but can grow to enormous size, and preoperative diagnosis is difficult with diverse, mostly malignant differential diagnoses that would lead to aggressive therapy. Since lipoblastoma is a benign tumor that has an excellent prognosis after resection, correct diagnosis is crucial.

Case presentation
A case of a large retroperitoneal tumor of a 24-month old infant that was clinically suspicious of a malignant tumor is presented. Due to proximity to the right kidney, clinically most probably a nephroblastoma or clear cell sarcoma of the kidney was suspected. Radiological findings were ambiguous. Therefore, the mass was biopsied, and histology revealed an adipocytic lesion. Although mostly composed of mature adipocytes, in view of the age of the patient, the differential diagnosis of a (maturing) lipoblastoma was raised, which was supported by molecular analysis demonstrating a HAS2-PLAG1 fusion. The tumor was completely resected, and further histopathological workup led to the final diagnosis of a 13 cm large retroperitoneal maturing lipoblastoma. The child recovered promptly from surgery and showed no evidence of recurrence so far.

Conclusion
Although rare, lipoblastoma should be included in the differential diagnoses of retroperitoneal tumors in infants and children, and molecular diagnostic approaches could be a helpful diagnostic adjunct in challenging cases.
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Authors: Cheng Yuan , Mo Fei , Li Qingfang , Han Xuejiao , Shi Houhui , Chen Siyuan , Wei Yuquan , Wei Xiawei 
Published: April 2021

Abstract
Background
Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role in progression of cancer including lung cancer. However, the specific anti-cancer mechanism of targeting CXCR2 remains unclear.

Methods
Immunohistochemical analysis of CXCR2 was performed on the microarray of tumor tissues of clinical lung adenocarcinoma and lung squamous cell carcinoma patients. CCK8 test, TUNEL immunofluorescence staining, PI-Annexin V staining, β-galactosidase staining, and Western blot were used to verify the role of CXCR2 in vitro. Animal models of tail vein and subcutaneous injection were applied to investigate the therapeutic role of targeting CXCR2. Flow cytometry, qRT-PCR, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry analysis were performed for further mechanistic investigation.

Results
The expression of CXCR2 was elevated in both human lung cancer stroma and tumor cells, which was associated with patients’ prognosis. Inhibition of CXCR2 promoted apoptosis, senescence, epithelial-to-mesenchymal transition (EMT), and anti-proliferation of lung cancer cells. In vivo study showed that tumor-associated neutrophils (TANs) were significantly infiltrate into tumor tissues of mouse model, with up-regulated CXCLs/CXCR2 signaling and suppressive molecules, including Arg-1 and TGF-β. SB225002, a selective inhibitor of CXCR2 showed promising therapeutic effect, and significantly reduced infiltration of neutrophils and enhanced anti-tumor T cell activity via promoting CD8+ T cell activation. Meanwhile, blockade of CXCR2 could enhance therapeutic effect of cisplatin via regulation of neutrophils infiltration.

Conclusions
Our finds verify the therapeutic effects of targeting CXCR2 in lung cancer and uncover the potential mechanism for the increased sensitivity to chemotherapeutic agents by antagonists of CXCR2.
The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
Authors: Uddin Mohammad Burhan , Wang Zhishan , Yang Chengfeng 
Published: April 2021

AbstractThe m6A RNA methylation is the most prevalent internal modification in mammalian mRNAs which plays critical biological roles by regulating vital cellular processes. Dysregulations of the m6A modification due to aberrant expression of its regulatory proteins are frequently observed in many pathological conditions, particularly in cancer. Normal cells undergo malignant transformation via activation or modulation of different oncogenic signaling pathways through complex mechanisms. Accumulating evidence showing regulation of oncogenic signaling pathways at the epitranscriptomic level has added an extra layer of the complexity. In particular, recent studies demonstrated that, in many types of cancers various oncogenic signaling pathways are modulated by the m6A modification in the target mRNAs as well as noncoding RNA transcripts. m6A modifications in these RNA molecules control their fate and metabolism by regulating their stability, translation or subcellular localizations. In this review we discussed recent exciting studies on oncogenic signaling pathways that are modulated by the m6A RNA modification and/or their regulators in cancer and provided perspectives for further studies. The regulation of oncogenic signaling pathways by the m6A modification and its regulators also render them as potential druggable targets for the treatment of cancer.
Bilateral pelvic kidneys with upper pole fusion and malrotation: a case report and review of the literature
Authors: Khougali Hussam S. , Alawad Omer Ali Mohamed Ahmed , Farkas Nicholas , Ahmed Mohammed Mahgoub Mirghani , Abuagla Alnasri Mohammed 
Published: April 2021

Abstract
Background
The incidence of ectopic kidneys is 1:12,000 clinically and 1:900 postmortem. Patients with pelvic mal-rotated kidneys are more susceptible to recurrent urinary tract infections, recurrent renal stones, and renal injury. Fusion of the kidney lower poles is relatively common compared to other types of renal anomalies.

Case presentation
We present the case of a 36-year-old Sudanese female patient who presented with a long history of recurrent urinary tract infections unresponsive to antibiotics. Ultrasound scan revealed bilateral pelvic kidneys. Computed tomography (CT) urography confirmed bilateral ectopic fused kidneys, with the left kidney mal-rotated (renal pelvis facing upwards and laterally). Kidney infection secondary to vesicoureteral reflux was diagnosed. Antibiotics were prescribed according to culture and sensitivity. The patient responded well to ciprofloxacin.

Conclusion
A history of recurrent urinary tract infections without an apparent cause is highly suggestive of renal anomaly and should be investigated expediently. Ultrasonography or CT imaging may be utilized to aid in diagnosis. Early recognition may help prevent the high risk of end-stage renal failure associated with anomalies.
Commoning of territorial heritage and tools of participated sustainability for the production and enhancement of agro-environmental public goods
Authors: Safonte G. Fabiola , Bellia Claudio , Columba Pietro 
Published: April 2021

AbstractThe purpose of this paper is to analyze how the commoning heritage processes find application for the production of agro-environmental public goods in contexts of high socio-economic marginality and environmental vulnerability, characterized by abandonment and from the consumption of agricultural land for food use. The purpose is to understand how these processes are able to influence, at local level, the governance processes for the implementation of environmental protection strategies. The survey made it possible to verify how the commoning processes aimed at the production of agro-environmental goods generate territorial resilience, understood as a community competence able to structure specific forms of social learning based on priorities identified and defined by the communities. The followed theoretical framework and the methodological approach have allowed on the one hand to draw up a taxonomy of the different territorial dynamics and on the other to identify a mixed indicator system, applicable and replicable also in other contexts, able to describe its dimensions analytically. The assessment of the cognitive elements related to the territorial fabric carried out through the proposed approach has allowed to demonstrate how the knowledge of the territorial capital contributes to the activation of forms of collective intelligence necessary for decision-making processes.
The impact of K-beauty social media influencers, sponsorship, and product exposure on consumer acceptance of new products
Authors: Wang Lei , Lee Jin Hwa 
Published: April 2021

AbstractThis research identified the different ways in which K-beauty social media influencers (SMIs) impact consumers’ tendencies to accept new products by closely investigating their sponsorship displays and product exposure methods. We conducted an experiment to examine how influencers’ posts affect Chinese millennial consumers’ acceptance of new products. We used a 2 (influencer type: celebrity versus general public) × 2 (sponsorship display status: display versus no display) × 2 (product exposure method: exposure versus no exposure) factorial design. The findings reveal that the social media posts that made consumers most likely to accept a new product were created by a general public influencer and did not include a display of any sponsorship affiliation with the product. Additionally, there was a significant interplay between the influencer type, sponsorship display status, and product exposure method regarding consumers’ acceptance intention toward a new product. A consumer was most likely to accept and purchase a new product when three factors (general public influencer, sponsorship displayed, and product exposed) were combined. Based on the findings, we draw important implications and present marketing strategies for companies in the beauty industry that use SMI marketing.
Fabrication of silica/PVA-co-PE nanofiber membrane for oil/water separation
Authors: Chen Yuanli , Fan Hui , Zha Xinlin , Wang Wenwen , Wu Yi , Xiong Yi , Yan Kun , Wang Yuedan , Wang Dong 
Published: April 2021

AbstractHigh efficiency and anti-pollution oil/water separation membrane has been widely explored and researched. There are a large number of hydroxyl groups on the surface of silica, which has good wettability and can be used for oil-water separation membranes. Hydrophilic silica nanostructures with different morphologies were synthesized by changing templates and contents of trimethylbenzene (TMB). Here, silica nanospheres with radical pores, hollow silica nanospheres and worm-like silica nanotubes were separately sprayed on the PVA-co-PE nanofiber membrane (PM). The abundance of hydroxyl groups and porous structures on PM surfaces enabled the absorption of silica nanospheres through hydrogen bonds. Compared with different silica nanostructures, it was found that the silica/PM exhibited excellent super-hydrophilicity in air and underwater “oil-hating” properties. The PM was mass-produced in our lab through melt-extrusion-phase-separation technique. Therefore, the obtained membranes not only have excellent underwater superoleophobicity but also have a low-cost production. The prepared silica/PM composites were used to separate n-hexane/water, silicone oil/water and peanut oil water mixtures via filtration. As a result, they all exhibited efficient separation of oil/water mixture through gravity-driven filtration.
Analytical solutions and 3D numerical analyses of a shallow tunnel excavated in weak ground: a case from Turkey
Authors: Aygar Ebu Bekir , Gokceoglu Candan 
Published: April 2021

AbstractDue to the increasing population and resulting transportation needs, the number of subway and high-speed railway projects has also increased. The geometric constraints of such projects have caused many tunnels to be built in weak ground. Thus, weak ground tunnelling has attracted the attention of tunnel engineers and researchers. The main purposes of this study are to analyse the T4 tunnel excavated in weak ground and to compare the results obtained from the analytical solutions and 3D numerical analyses. This study specifically considers the T4 tunnel support system used in the Ankara İzmir High Speed Railway Project (Afyonkarahisar-Banaz Section). The T4 tunnel route encounters weak ground composed of layers of extremely weak mudstone, clayey sand, weakly cemented sandstone, and silty–clay matrix with pebbles. The tunnel overburden ranges from 10 to 35 m, which is shallow. After the excavation work of the T4 tunnel, severe deformation and critical stability problems in the shallow part (where the overburden is approximately 10 m) were encountered inside the tunnel, leading to a halt in construction. This was followed by revisions to the tunnel support system, leading to successful completion of the tunnel excavation. Numerical simulations of the low overburden section are performed using the commercially available FLAC3D program that uses the finite difference method. The characteristics of insufficient/ineffective support systems and adequate support systems for shallow tunnels excavated through weak ground are discussed in this study. Additionally, problems that pertain to the tunnel itself and its support system are discussed. The results of the 3D numerical analyses and analytical solutions are compared, and the advantages of 3D numerical analyses are discussed. The importance and necessity of tunnel face stability and roof stability for tunnel stability in weak ground is illustrated. Consequently, solutions based on analytical and numerical analyses are presented, and the analysis methodology and solutions proposed in the study can help guide weak ground tunnelling design and evaluation.