bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Indomalayan Nebularmis species (Heterotardigrada: Echiniscidae) provoke a discussion on its intrageneric diversity
Authors: Gąsiorek Piotr , Vončina Katarzyna , Ciosek Joanna , Veloso Mariana , Fontoura Paulo , Michalczyk Łukasz 
Published: April 2021

AbstractRecent years have brought undeniable progress in tardigrade taxonomy, and speciose complexes were detected in a number of phylogenetic lineages. The family Echiniscidae is one such lineage; it is one of the most diverse groups of limno-terrestrial tardigrades and can be characterized as having achieved great evolutionary success. In this contribution, using populations representing several species that originated from the Indomalayan region, we reconstructed phylogenetic affinities within Nebularmis, a recently erected genus within the Echiniscus lineage. Nebularmis auratussp. nov. and Nebularmis burmensissp. nov. are described from the Eastern Yoma Mountains and the Shan Hills (Myanmar), Nebularmis bhutanensissp. nov. is described from the Eastern Himalayas (Bhutan), and Nebularmis indicussp. nov. is described from the foothills of the Western Ghats (Goa, India). Moreover, males are reported in populations of the last two species. All known members of the genus can be phenotypically differentiated based on minute details of their dorsal sculpture and claws. Moreover, a very wide tropical distribution is demonstrated for Nebularmis cirinoi, recorded for the first time from islands of the Malay Archipelago. Furthemore, novel morphological, genetic, and geographic data allowed for the clarification of the generic diagnosis. Currently available data favor a scenario under which Nebularmis evolved in Southeast Asia and later dispersed to other regions of the globe.
Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy
Authors: Boyer David S. , Rippmann Joerg F. , Ehrlich Michael S. , Bakker Remko A. , Chong Victor , Nguyen Quan Dong 
Published: April 2021

Abstract
Background
Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost. There is a need for treatments for non-proliferative diabetic retinopathy (NPDR) which, in comparison with current intravitreal (IVT) injections, offer an improved risk–benefit ratio and are suitable for the treatment of early stages of disease, during which there is no major visual impairment. Efficacious systemic therapy for NPDR, including oral treatment, would be an important and convenient therapeutic approach for patients and physicians and would reduce treatment burden. In this article, we review the rationale for the investigation of amine oxidase copper-containing 3 (AOC3), also known as semicarbazide-sensitive amine oxidase and vascular adhesion protein 1 (VAP1), as a novel target for the early treatment of moderate to severe NPDR. AOC3 is a membrane-bound adhesion protein that facilitates the binding of leukocytes to the retinal endothelium. Adherent leukocytes reduce blood flow and in turn rupture blood vessels, leading to ischemia and edema. AOC3 inhibition reduces leukocyte recruitment and is predicted to decrease the production of reactive oxygen species, thereby correcting the underlying hypoxia, ischemia, and edema seen in DR, as well as improving vascular function.

Conclusion
There is substantial unmet need for convenient, non-invasive treatments targeting moderately severe and severe NPDR to reduce progression and preserve vision. The existing pharmacotherapies (IVT corticosteroids and IVT anti-vascular endothelial growth factor-A) target inflammation and angiogenesis, respectively. Unlike these treatments, AOC3 inhibition is predicted to address the underlying hypoxia and ischemia seen in DR. AOC3 inhibitors represent a promising therapeutic strategy for treating patients with DR and could offer greater choice and reduce treatment burden, with the potential to improve patient compliance.
18F-FACBC PET/MRI in the evaluation of human brain metastases: a case report
Authors: Johannessen Knut , Berntsen Erik Magnus , Johansen Håkon , Solheim Tora S. , Karlberg Anna , Eikenes Live 
Published: April 2021

Abstract
Background
Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in detecting micro-metastases, delineating lesions and discriminating progression from pseudo-progression. Combined PET/MRI utilises superior soft tissue images from MRI and metabolic data from PET to evaluate tumour structure and function. The amino acid PET tracer 18F-FACBC has shown promising results in discriminating high- and low-grade gliomas, but there are currently no reports on its use on brain metastases. This is the first study to evaluate the use of 18F-FACBC on brain metastases.

Case presentation
A middle-aged female patient with brain metastases was evaluated using hybrid PET/MRI with 18F-FACBC before and after stereotactic radiotherapy, and at suspicion of recurrence. Static/dynamic PET and contrast-enhanced T1 MRI data were acquired and analysed. This case report includes the analysis of four 18F-FACBC PET/MRI examinations, investigating their utility in evaluating functional and structural metastasis properties.

Conclusion
Analysis showed high tumour-to-background ratios in brain metastases compared to other amino acid PET tracers, including high uptake in a very small cerebellar metastasis, suggesting that 18F-FACBC PET can provide early detection of otherwise overlooked metastases. Further studies to determine a threshold for 18F-FACBC brain tumour boundaries and explore its utility in clinical practice should be performed.
A methodology for energy key performance indicators analysis
Authors: Faria Pedro , Lezama Fernando , Vale Zita , Khorram Mahsa 
Published: April 2021

AbstractWith the advent of the smart grid era, the electrical grid is becoming a complex network in which different technologies coexist to bring benefits to both customers and operators. This paper presents a methodology for analyzing Key Performance Indicators (KPIs), providing knowledge about the performance and efficiency of energy systems, focusing on the demand side. In the first stage of the methodology, the baseline KPIs are calculated. In the second stage, all KPIs are updated to be compared with the baseline ones. In fact, due to the dynamic nature of players in a smart grid, this methodology plays a crucial role in the performance assessment. Moreover, the proper definition and selection of KPIs is usually a challenging task since KPIs can be applied to evaluate diverse areas within a smart grid. Such areas include building energy efficiency, home communications, and smart metering deployment, just to mention a few. In the proposed methodology, the information obtained from a KPI can be driven to distinct aspects such as efficiency, environment, reliability, power quality, safety, security, or cost reduction. Through a case study from a real implementation of an energy system, we show how to assess energy consumption efficiency, thus improving energy management.
Industrial hemp as an agricultural crop in Ghana
Authors: Owusu Nana Osei , Arthur Benedict , Aboagye Emmanuel Mensah 
Published: April 2021

Abstract
Background
Cannabis is one of humanity’s oldest crops with several uses, from food to clothing and medicine. It remains one of the most controversial crops whose production, possession, and usage are regulated differently across jurisdictions. Academic research and advocacy have resulted in the redefinition of the legal status of cannabis in several countries. Ghana recently reviewed its laws on cannabis, allowing for the cultivation of industrial hemp. The legislation paves the way for Ghana to benefit from industrial hemp and include it in the agricultural cash crop list. This paper looks at the economic prospects of industrial hemp in the wake of the new law.

Methods
A systematic electronic research was conducted to identify journal articles, reports, news, blogs, and other relevant materials on cannabis, marijuana, and industrial hemp. The electronic search was done primarily on Google, Google Scholar, Bing, and “Baidu Xueshi” to identify cannabis-related publications. The search was expanded beyond Ghana to find other perspectives on cannabis. The search began in January 2020 on Google using search terms like “cannabis in Ghana” and “which countries have legal cannabis.” Materials on history, financial prospects, industrial uses, and legislations on cannabis and industrial hemp were reviewed.

Results
Existing research on cannabis in Ghana has focused on the psychotic effects of cannabis other than its industrial aspects, which has potentials for the economy. Industrial hemp has CBD with no psychotic effects and is very useful in making medicine, paper, and textiles. Ghana has both the land and workforce to produce hemp to feed local industries and the international market.

Conclusion
The new legislation can put Ghana in a position to benefit from the current cannabis industry. Therefore, policymakers should implement a registration regime that would favor local investors and farmers to reduce illegal production. The regulatory framework should establish a well-equipped agency that will supervise production and research into hemp development.
The turbidite-contourite-tidalite-baroclinite-hybridite problem: orthodoxy vs. empirical evidence behind the “Bouma Sequence”
Authors: Shanmugam G. 
Published: April 2021

AbstractThe underpinning problems of deep-water facies still remain unresolved. (1) The Tb, Tc, and Td divisions of the turbidite facies model, with traction structures, are an integral part of the “Bouma Sequence” (Ta, Tb, Tc, Td, Te). However, deposits of thermohaline contour currents, wind-driven bottom currents, deep-marine tidal currents, and baroclinic currents (internal waves and tides) also develop discrete rippled units, mimicking Tc. (2) The application of “cut-out” logic of sequences, which was originally introduced for the “Bouma Sequence”, with sharp basal contacts and sandy divisions containing well-developed traction structures, to muddy contourites with gradational basal contacts and an absence of well-developed traction structures is incongruent. (3) The presence of five internal divisions and hiatus in the muddy contourite facies model is in dispute. (4) Intersection of along slope contour currents with down slope sediment-gravity flows, triggering hybrid flows, also develops traction structures. (5) The comparison of genuine hybrid flows with down slope flow transformation of gravity flows is inconsistent with etymology of the term “hybrid”. (6) A reexamination of the Annot Sandstone at the Peira Cava type locality in SE France fails to validate either the orthodoxy of five internal divisions of the “Bouma Sequence” or their origin by turbidity currents. For example, the “Ta” division is composed of amalgamated units with inverse grading and floating mudstone clasts, suggesting a mass-transport deposit (MTD). The “Tb” and “Tc” divisions are composed of double mud layers and sigmoidal cross bedding, respectively, which suggest a tidalite origin. (7) Although it was reasonable to introduce a simplistic “Bouma Sequence” in 1962, at a time of limited knowledge on deep-water processes, it is obsolete now in 2021 to apply this model to the rock record amid a wealth of new knowledge. (8) The disconnect between 12 observed, but questionable, modern turbidity currents and over 10,000 interpreted ancient turbidites defies the doctrine of uniformitarianism. This disconnect is attributed to routine application of genetic facies models, without a pragmatic interpretation of empirical data. (9) A suggested solution to these problems is to interpret traction structures in the sedimentary record pragmatically on the basis of empirical field and experimental evidence, without any built-in bias using facies models, such as the “Bouma Sequence”. (10) Until reliable criteria are developed to distinguish traction structures of each type of bottom currents based on uniformitarianism, a general term “BCRS” (i.e., bottom-current reworked sands) is appropriate for deposits of all four kinds of bottom currents.
Unified gas-kinetic wave-particle methods IV: multi-species gas mixture and plasma transport
Authors: Liu Chang , Xu Kun 
Published: April 2021

AbstractIn this paper, we extend the unified gas-kinetic wave-particle (UGKWP) methods to the multi-species gas mixture and multiscale plasma transport. The construction of the scheme is based on the direct modeling on the mesh size and time step scales, and the local cell’s Knudsen number determines the flow physics. The proposed scheme has the multiscale and asymptotic complexity diminishing properties. The multiscale property means that according to the cell’s Knudsen number the scheme can capture the non-equilibrium flow physics when the cell size is on the kinetic mean free path scale, and preserve the asymptotic Euler, Navier-Stokes, and magnetohydrodynamics (MHD) when the cell size is on the hydrodynamic scale and is much larger than the particle mean free path. The asymptotic complexity diminishing property means that the total degrees of freedom of the scheme reduce automatically with the decreasing of the cell’s Knudsen number. In the continuum regime, the scheme automatically degenerates from a kinetic solver to a hydrodynamic solver. In the UGKWP, the evolution of microscopic velocity distribution is coupled with the evolution of macroscopic variables, and the particle evolution as well as the macroscopic fluxes is modeled from a time accumulating solution of kinetic scale particle transport and collision up to a time step scale. For plasma transport, the current scheme provides a smooth transition from particle-in-cell (PIC) method in the rarefied regime to the magnetohydrodynamic solver in the continuum regime. In the continuum limit, the cell size and time step of the UGKWP method are not restricted by the particle mean free path and mean collision time. In the highly magnetized regime, the cell size and time step are not restricted by the Debye length and plasma cyclotron period. The multiscale and asymptotic complexity diminishing properties of the scheme are verified by numerical tests in multiple flow regimes.
Effects of posterior tibial slope on the mid-term results of medial unicompartmental knee arthroplasty
Authors: Chen Zhijie , Chen Kaizhe , Yan Yufei , Feng Jianmin , Wang Yi , Liu Zhihong , Yang Qingming , He Chuan 
Published: April 2021

Abstract
Objective
To evaluate the effect of medial posterior tibial slope (PTS) on mid-term postoperative range of motion (ROM) and functional improvement of the knee after medial unicompartmental knee arthroplasty (UKA).

Methods
Medical records of 113 patients who had undergone 124 medial UKAs between April 2009 through April 2014 were reviewed retrospectively. The mean follow-up lasted 7.6 years (range, 6.2–11.2 years). Collected were demographic data, including gender, age, height, weight of the patients. Anteroposterior (AP) and lateral knee radiographs of the operated knees were available in all patients. The knee function was evaluated during office follow-up or hospital stay. Meanwhile, postoperative PTS, ROM, maximal knee flexion and Hospital for Special Surgery (HSS) knee score (pre−/postoperative) of the operated side were measured and assessed. According to the size of the PTS, patients were divided into 3 groups: group 1 (<4°), group 2 (4° ~ 7°) and group 3 (>7°). The association between PTS and the knee function was investigated.

Results
In our cohort, the average PTS was 2.7° ± 0.6° in group 1, 5.6° ± 0.9° in group 2 and 8.7° ± 1.2° in group 3. Pairwise comparisons showed significant differences among them (p < 0.01). The average maximal flexion range of postoperative knees in each group was 112.4° ± 5.6°, 116.4° ± 7.2°, and 117.5° ± 6.1°, respectively, with significant difference found between group 1 and group 2 (p < 0.05), and between group 1 and group 3 (p < 0.05). However, the gender, age, and body mass index (BMI) did not differ between three groups and there was no significant difference between groups in terms of pre−/postoperative HSS scores or postoperative knee ROM.

Conclusion
A mid-term follow-up showed that an appropriate PTS (4° ~ 7°) can help improve the postoperative flexion of knee. On the other hand, too small a PTS could lead to limited postoperative knee flexion. Therefore, the PTS less than 4° should be avoided during medial UKA.
Implementing immediate postpartum contraception: a comparative case study at 11 hospitals
Authors: Moniz Michelle H. , Bonawitz Kirsten , Wetmore Marisa K. , Dalton Vanessa K. , Damschroder Laura J. , Forman Jane H. , Peahl Alex F. , Heisler Michele 
Published: April 2021

Abstract
Background
Immediate postpartum long-acting reversible contraception (LARC) is an evidence-based practice, but hospitals face significant barriers to its adoption. Our objective was to examine how organizational context (e.g., size, employee attitudes toward the clinical practice) and implementation strategies (i.e., the actions taken to routinize a clinical practice) drive successful implementation of immediate postpartum LARC services, with a goal of informing the design of future implementation interventions.

Methods
We conducted a comparative case study of the implementation of inpatient postpartum contraceptive care at 11 US maternity hospitals. In 2017–2018, we conducted site visits that included semi-structured key informant interviews informed by the Consolidated Framework for Implementation Research. Qualitative measures of implementation success included stakeholder satisfaction, routinization, and sustainability of immediate postpartum LARC services. Qualitative content analysis and cross-case synthesis explored relationships among organizational context, implementation strategies, and implementation success.

Results
We completed semi-structured interviews with 78 clinicians, nurses, residents, pharmacy and revenue cycle staff, and hospital administrators. Successful implementation required three essential conditions: effective implementation champions, an enabling financial environment, and hospital administrator engagement. Six other contextual conditions were influential: trust and effective communication, alignment with stakeholders’ professional values, perception of meeting patients’ needs, robust learning climate, compatibility with workflow, and positive attitudes and adequate knowledge about the clinical practice. On average, sites used 18 (range 11-22) strategies. Strategies to optimize the financial environment and train clinicians and staff were commonly used. Strategies to plan and evaluate implementation and to engage patients emerged as promising to address barriers to practice change, yet were often underused.

Conclusions
Implementation efforts in maternity settings may be more successful if they select strategies to optimize local conditions for success. Our findings elucidate key contextual conditions to target and provide a menu of promising implementation strategies for incorporating recommended contraceptive services into routine maternity practice. Additional prospective research should evaluate whether these strategies effectively optimize local conditions for successful implementation in a variety of settings.
Prevalence and risk factors of endoscopically confirmed gastroesophageal reflux disease (GERD) in patients with liver cirrhosis
Authors: Hassanin Taha M. , Foaud Yasser , Mohamed Hala , Saad Zienab , Elsayed Amr , Refaei Sara , Soliman Wael 
Published: April 2021

Abstract
Background
Gastroesophageal reflux disease (GERD) is one of the most common diseases in modern civilization that originates basically from a disturbance in the structure and function of the lower esophageal sphincter (LES). Liver cirrhosis with or without esophageal varices (EV) may predispose to GERD, and GERD may precipitate rupture of esophageal varices. As variceal bleeding is a serious life-threatening complication of liver cirrhosis, GERD prevalence among cirrhotic patients is continuously subjected to research. We aimed to determine the prevalence of endoscopy-confirmed GERD in patients with liver cirrhosis and its possible risk factors. So, one hundred patients with HCV-related liver cirrhosis were consecutively enrolled in this study. They were subjected to history taking {including Reflux Disease Questionnaire}, thorough clinical examination, abdominal ultrasound, and lab investigations and then referred for upper endoscopy to screen for GERD and/or esophageal varices.

Results
GERD was endoscopically confirmed in 83 patients (83%) and the highest prevalence was in patients with Child B and C. Among 82 patients with esophageal varices, there were 68 patients who had endoscopic GERD (82.9%), and among 62 patients with ascites, there were 56 patients who had endoscopic GERD (90.3%).

Conclusion
We found a high prevalence of GERD (83%) among patients with liver cirrhosis. The severity of GERD was significantly related to the Child grade, the grade of varices, and the degree of ascites but ascites was the only significant risk factor for GERD development in cirrhotic patients.
Novel stability-indicating RP-UPLC method for simultaneous estimation of sitagliptin and ertugliflozin in bulk and pharmaceutical formulations
Authors: B Ramya kuber , Addanki Swetha 
Published: April 2021

Abstract
Background
The present investigation was proposed to develop a simple, sensitive, rapid, accurate, precise stability-indicating RP-UPLC method for simultaneous estimation of sitagliptin and ertugliflozin. Chromatographic separation was performed with Waters Hibar C8 [100×2.1mm, 2μ] column and mobile phase acetonitrile: water (pH 3.5) [50:50%, v/v], pumped at a flow rate 0.2ml/min. The separated analytes were detected with a UV detector at a wavelength of 218nm.

Results
The separation of sitagliptin and ertugliflozin was done at a retention time of 0.859min and 1.570min, respectively. The present method was validated according to the ICH guidelines Q2 R1, and stability-indicating studies were carried out as per ICH guidelines Q1A R2. Intra-day and inter-day precision were found to be within acceptable limits. The linearity of the proposed method was in the concentration range of 25–125μg/ml and 3.75–22.5μg/ml for sitagliptin and ertugliflozin, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.5μg/ml and 1.53μg/ml for sitagliptin and 0.13μg/ml and 0.38μg/ml for ertugliflozin, respectively. The recovery of the method was found in between 99.7% and 100.7%.

Conclusion
The proposed method was able to distinguish the analytes from by-products. Hence, the method was successfully implied for stability-indicating studies and for routine examination of sitagliptin and ertugliflozin in pharmaceutical formulation.