bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental and Child Self‐Efficacy Explaining Food Intake through Self‐Regulation: A Dyadic Prospective Study
Authors: Zarychta Karolina , Banik Anna , Kulis Ewa , Lobczowska Karolina 
Published: February 2021

BackgroundAccording to social cognitive theory and socio‐ecological models, self‐efficacy and temptation‐related self‐regulation (the use of distraction or suppression) are modifiable predictors of health behaviors, such as food intake. Yet, there is limited evidence explaining how these factors are interlinked among parent‐child dyads. This study investigated indirect effects of parental and child self‐efficacy on food intake, via parental and child self‐regulation.MethodsThe prospective study (the baseline [T1] and the 10‐month follow‐up [T2]) enrolled 924 parent‐child dyads (1,848 individuals; 54.3% girls, aged 5–11 years, 88.9% mothers). Dyads were interviewed or completed self‐report measures. Path analyses with maximum likelihood estimation were conducted.ResultsChild self‐efficacy and distraction (T1) mediated between parental self‐efficacy (T1) and higher levels of child fruit and vegetable intake (T2). No significant mediating effects of suppression were found, nor indirect effects of parental self‐efficacy (T1) on energy‐dense food intake (T2).ConclusionHealth promotion interventions aiming at changing fruit and vegetable intake among 5–11‐year‐old children should target enhancing parental and child self‐efficacy that may facilitate the use of self‐regulation and, in turn, healthy diet.
Long‐term lithium therapy and risk of chronic kidney disease in bipolar disorder: A historical cohort study
Authors: Pahwa Mehak , Joseph Boney , Nunez Nicolas A. , Jenkins Gregory D. , Colby Colin L. , Kashani Kianoush B. , Veldic Marin , Moore Katherine M. , Betcher Hannah K. , Ozerdem Aysegul , Cuellar‐Barboza Alfredo B. , McElroy Susan L. , Biernacka Joanna M. , Frye Mark A. , Singh Balwinder 
Published: February 2021

AbstractAimsLong‐term lithium therapy (LTLT) has been associated with kidney insufficiency in bipolar disorder (BD). We aimed to investigate the risk factors of chronic kidney disease (CKD) development and progression among BD patients receiving LTLT.MethodsWe included adult patients with BD on LTLT (≥1 year) who were enrolled in the Mayo Clinic Bipolar Biobank, Rochester, Minnesota. We reviewed electronic medical records to extract information related to lithium therapy and kidney‐related data to assess changes in the estimated glomerular filtration rate (eGFR). CKD severity was assessed based on eGFR.ResultsAmong 154 patients who received LTLT, 41 patients (27%) developed CKD, of whom 20 (49%) patients continued lithium (continuers) and 19 (46%) discontinued it (discontinuers). The median time to stage 3 CKD development was 21.7 years from the start of Li treatment. Type‐2 diabetes mellitus and benzodiazepine use were independent predictors for CKD development in the survival analysis, after controlling for age. The subsequent CKD progression rate did not differ between continuers and discontinuers (mean GFR 48.6 vs. 44.1, p = 0.13) at the end of follow‐up duration (mean duration: 3.5 ± 4.4 years for continuers and 4.9 ± 5.3 years for discontinuers).ConclusionCKD was observed in one fourth of patients with BD receiving LTLT. There was no significant difference in the progression of CKD among Li continuers versus discontinuers, at the mean follow‐up duration of 4.2 years, after the CKD diagnosis. Progression of CKD could be influenced by existing comorbidities and may not necessarily be due to lithium alone.
Stopping exploitation: Properly remunerating healthcare workers for risk in the COVID‐19 pandemic
Authors: Giubilini Alberto , Savulescu Julian 
Published: February 2021

AbstractWe argue that we should provide extra payment not only for extra time worked but also for the extra risks healthcare workers (and those working in healthcare settings) incur while caring for COVID‐19 patients—and more generally when caring for patients poses them at significantly higher risks than normal. We argue that the extra payment is warranted regardless of whether healthcare workers have a professional obligation to provide such risky healthcare. Payment for risk would meet four essential ethical requirements. First, assuming healthcare workers do not have a professional obligation to take on themselves the risks, payments in the form of incentives would preserve autonomy in deciding what risks to take on oneself. Second, even assuming that healthcare workers do have a professional obligation to take on themselves the risks, payments for risk would create fair working conditions by avoiding exploitation. Third, payments for risk would make it more likely that public healthcare systems can discharge their institutional responsibility to provide healthcare in circumstances where healthcare workers may otherwise (perhaps legitimately) opt out. Fourth, payments for risk would guarantee an efficient healthcare system in pandemic situations. Finally, we address two likely objections that some might raise against our proposal, particularly with regard to incentives, namely that such payments or incentives can themselves be coercive and that they represent a form of undue inducement.
Reproductive genome editing interventions are therapeutic, sometimes
Authors: Palacios‐González César 
Published: February 2021

AbstractIn this paper I argue that some human reproductive genome editing interventions can be therapeutic in nature, and thus that it is false that all such interventions just create healthy individuals. I do this by showing that the conditions established by a therapy definition are met by certain reproductive genome editing interventions. I then defend this position against two objections: (a) reproductive genome editing interventions do not attain one of the two conditions for something to be a therapy, and (b) some reproductive genome editing interventions are therapeutic but in a nonstandard way. In the Conclusion I call for a more nuanced discussion of the nature of reproductive genome editing interventions.
Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor
Authors: Nishiya Naoyuki , Oku Yusuke , Ishikawa Chie , Fukuda Tsutomu , Dan Shingo , Mashima Tetsuo , Ushijima Masaru , Furukawa Yoko , Sasaki Yuka , Otsu Keishi , Sakyo Tomoko , Abe Masanori , Yonezawa Honami , Ishibashi Fumito , Matsuura Masaaki , Tomida Akihiro , Seimiya Hiroyuki , Yamori Takao , Iwao Masatomo , Uehara Yoshimasa 
Published: February 2021

AbstractThe emergence of acquired resistance is a major concern associated with molecularly targeted kinase inhibitors. The C797S mutation in the epidermal growth factor receptor (EGFR) confers resistance to osimertinib, a third‐generation EGFR‐tyrosine kinase inhibitor (EGFR‐TKI). We report that the derivatization of the marine alkaloid topoisomerase inhibitor lamellarin N provides a structurally new class of EGFR‐TKIs. One of these, lamellarin 14, is effective against the C797S mutant EGFR. Bioinformatic analyses revealed that the derivatization transformed the topoisomerase inhibitor‐like biological activity of lamellarin N into kinase inhibitor‐like activity. Ba/F3 and PC‐9 cells expressing the EGFR in‐frame deletion within exon 19 (del ex19)/T790M/C797S triple‐mutant were sensitive to lamellarin 14 in a dose range similar to the effective dose for cells expressing EGFR del ex19 or del ex19/T790M. Lamellarin 14 decreased the autophosphorylation of EGFR and the downstream signaling in the triple‐mutant EGFR PC‐9 cells. Furthermore, intraperitoneal administration of 10 mg/kg lamellarin 14 for 17 days suppressed tumor growth of the triple‐mutant EGFR PC‐9 cells in a mouse xenograft model using BALB/c nu/nu mice. Thus, lamellarin 14 serves as a novel structural backbone for an EGFR‐TKI that prevents the development of cross‐resistance against known drugs in this class.
Advanced colorectal cancer subtypes (aCRCS) help select oxaliplatin‐based or irinotecan‐based therapy for colorectal cancer
Authors: Takahashi Shin , Sakamoto Yasuhiro , Denda Tadamichi , Takashima Atsuo , Komatsu Yoshito , Nakamura Masato , Ohori Hisatsugu , Yamaguchi Tatsuro , Kobayashi Yoshimitsu , Baba Hideo , Kotake Masanori , Amagai Kenji , Kondo Hitoshi , Shimada Ken , Sato Atsushi , Yuki Satoshi , Okita Akira , Ouchi Kota , Komine Keigo , Watanabe Mika , Morita Satoshi , Ishioka Chikashi 
Published: February 2021

AbstractOxaliplatin (OX) and irinotecan (IRI) are used as key drugs for the first‐line treatment of metastatic colorectal cancer (mCRC). However, no biomarkers have been identified to decide which of the drugs is initially used. In this translational research (TR) of the TRICOLORE trial, the advanced colorectal cancer subtype (aCRCS) was analyzed as a potential biomarker for the selection of OX or IRI. We collected 335 (68.8%) formalin‐fixed, paraffin‐embedded (FFPE) primary tumor specimens from 487 patients registered in the TRICOLORE trial and performed direct sequencing and immunohistochemical staining of CRC‐related genes, comprehensive gene‐expression analysis, and genome‐wide methylation analysis. The progression‐free survival (PFS) of the IRI group was significantly better compared with the OX group in BRAF wild‐type (WT), PTEN‐positive, and aCRCS A1 patients. Among the molecular factors, aCRCS were only associated with the PFS of OX and IRI groups. The PFS of the IRI group was significantly better compared with the OX group in aCRCS A1 + B1 (hazard ratio [HR] = 0.58; 95% confidence interval [CI] = 0.41‐0.82; P = .0023). In contrast, the OX group had better PFS compared with the IRI group in aCRCS B2, although this was not statistically significant (HR = 1.66; 95% CI = 0.94‐2.96; P = .083). Nearly half of patients with mCRC (46.8%, aCRCS A1 + B1) respond well to IRI, while only about 18.5% (aCRCS B2) of patients with mCRC responded well to OX. In conclusion, the aCRCS might be a predictive factor for the clinical outcomes of OX‐based and IRI‐based therapies.
Outdoor pollen‐related changes in lung function and markers of airway inflammation: A systematic review and meta‐analysis
Authors: Idrose Nur Sabrina , Walters E. Haydn , Zhang Jingwen , Vicendese Don , Newbigin Ed J. , Douglass Jo A. , Erbas Bircan , Lowe Adrian J. , Perret Jennifer L. , Lodge Caroline J. , Dharmage Shyamali C. 
Published: February 2021

AbstractBackgroundExperimental challenge studies have shown that pollen can have early and delayed effects on the lungs and airways. Here, we qualitatively and quantitatively synthesize the evidence of outdoor pollen exposure on various lung function and airway inflammation markers in community‐based studies.MethodsFour online databases were searched: Medline, Web of Science, CINAHL and Google Scholar. The search strategy included terms relating to both exposure and outcomes. Inclusion criteria were human‐based studies published in English that were representative of the community. Additionally, we only considered cross‐sectional or short‐term longitudinal studies which investigated pollen exposure by levels or season. Study quality assessment was performed using the Newcastle‐Ottawa scale. Meta‐analysis was conducted using random‐effects models.ResultsWe included 27 of 6551 studies identified from the search. Qualitative synthesis indicated associations between pollen exposure and predominantly type‐2 inflammation in both the upper and lower airways, but little evidence for lung function changes. People with ever asthma and/or seasonal allergic rhinitis (SAR) were at higher risk of such airway inflammation. Meta‐analysis confirmed a positive relationship between pollen season, eosinophilia and eosinophil cationic protein (ECP) in people with ever SAR but the results between studies were highly variable. Heterogeneity was reduced after further subgrouping by age, and the forest plots indicated that eosinophilic airway inflammation to outdoor pollen exposure increased with age.ConclusionAmong people with ever asthma and ever SAR, exposure to increased ambient pollen triggers type‐2 upper and lower airway inflammation rather than a non‐specific or innate inflammation. These findings can lead to the formulation of specific pollen immunotherapy for susceptible individuals. Future research should be directed towards investigating lagged associations and effect modifications using larger and more generalized populations.Systematic review registrationCRD42020146981 (PROSPERO).
Predictability of ab‐interno trabeculectomy success in the subsequent eye: A contralateral eye comparison study
Authors: Kiessling David , Rennings Corinna , Hild Matthias , Lappas Alexandra , Dietlein Thomas S. , Roessler Gernot F. , Widder Randolf A. 
Published: February 2021

AbstractBackgroundTo determine whether the outcome of the first eye may serve as a predictor for intraocular pressure (IOP)‐lowering effectiveness in the second eye following bilateral ab interno trabeculectomy.MethodsThis retrospective single‐centre study included 168 eyes from 84 participants, who underwent combined Trabectome surgery with phacoemulsification cataract surgery in a hospital setting. The clinical endpoint was defined as either ‘success’ or ‘failure’ based on four separate scores at the longest follow‐up time point: IOP at follow‐up <21 mm Hg (Score A) or IOP < 18 mm Hg (Score B), without re‐surgery and IOP reduction >20%; IOP ≤15 mm Hg without re‐surgery and IOP reduction ≥40% (Score C); and the sole absence of re‐surgery according to the discretion of the surgeon (Score D).ResultsNo significant difference was observed between the outcomes of first and second eyes. The frequency of success in the second eye after effective surgery in the first eye significantly exceeded that after prior failure. Within our analysis, the probability calculations determined a 75% chance of success following prior success for Score A. If surgery in the first eye failed, the chance of success in the subsequent eye was 37%. The corresponding probabilities were 79% and 32% for Score B, 56% and 9% for Score C, and 99% and 50% for Score D.ConclusionThe results of our study offer a useful tool to assess the success of subsequent eye surgeries based on the outcome in the initial eye, owing to the high predictive potential.
Identifying the possibilities and pitfalls of conducting IUCN Red List assessments from remotely sensed habitat information based on insights from poorly known Cuban mammals
Authors: Duncan Clare , Böhm Monika , Turvey Samuel T. 
Published: February 2021

AbstractThe International Union for Conservation of Nature's Red List of Threatened Species (RLS) is the key global tool for objective, repeatable assessment of species’ extinction risk status, and plays an essential role in tracking biodiversity loss and guiding conservation action. Satellite remote sensing (SRS) data sets on global ecosystem distributions and functioning show exciting potential for informing range‐based RLS assessment, but their incorporation has been restricted by low temporal resolution and coverage of data sets, lack of incorporation of degradation‐driven habitat loss, and noninclusion of assumptions related to identification of changing habitat distributions for taxa with varying habitat dependency and ecologies. For poorly known mangrove‐associated Cuban hutias (Mesocapromysspp.), we tested the impact of possible assumptions regarding these issues on range‐based RLS assessment outcomes. Specifically, we used annual (1985–2018) Landsat data and land‐cover classification and habitat degradation analyses across different internal time series slices to simulate range‐based RLS assessments for our case study taxa to explore potential assessment uncertainty arising from temporal SRS data set coverage, incorporating proxies of (change in) habitat quality, and assumptions on spatial scaling of habitat extent for RLS parameter generation. We found extensive variation in simulated species‐specific range‐based RLS assessments, and this variation was mostly associated with the time series over which parameters were estimated. However, results of some species‐specific assessments differed by up to 3 categories (near threatened to critically endangered) within the same time series, due to the effects of incorporating habitat quality and the spatial scaling used in RLS parameter estimation. Our results showed that a one‐size‐fits‐all approach to incorporating SRS information in RLS assessment is inappropriate, and we urge caution in conducting range‐based assessments with SRS for species for which habitat dependence on specific ecosystem types is incompletely understood. We propose novel revisions to parameter spatial scaling guidelines to improve integration of existing time series data on ecosystem change into the RLS assessment process.
Monitoring of C‐reactive protein decreases length of stay after laparoscopic total mesorectal excision for cancer: a prospective case‐matched study in 236 patients
Authors: Cazelles Antoine , Giacca Massimo , Monsinjon Marie , Hain Elisabeth , Frontali Alice , Panis Yves 
Published: February 2021

AbstractAimThe aim of this study was to evaluate a discharge strategy driven by monitoring of C‐reactive protein (CRP) in a homogeneous group of patients undergoing laparoscopic total mesorectal excision with sphincter‐saving surgery for rectal cancer (TME).MethodOne hundred and thirteen patients who underwent a TME had CRP monitoring on postoperative day (POD) 5. Patients were discharged on POD 6 if the CRP level was ≤100 mg/L. Patients were matched (according to age, gender, body mass index, neoadjuvant pelvic irradiation and type of anastomosis) to 123 control patients who underwent the same operation with the same postoperative care but without CRP monitoring.ResultsPostoperative 3‐month overall [CRP group 62/113 (55%) vs controls 73/123 (59%); p = 0.487] and severe (i.e. Clavien–Dindo grade 3 and above) [CRP group 17/113 (15%) vs controls 19/123 (15%); p = 0.931] morbidity rates were similar between groups. Mean length of hospital stay (LHS) was significantly shorter in the CRP group (CRP group 9.7 ± 14 days vs controls 11.6 ± 7 days; p < 0.001). Discharge occurred on POD 6 in 55/113 (49%) patients from the CRP group vs 7/123 (6%) from the control group (p < 0.001). The rehospitalization rate [CRP group 19/113 (17%) vs controls 13/123 (11%); p = 0.177] was similar between groups. The CRP level on POD 5 had a diagnostic property to assess an anastomotic leakage with an area under the curve of 0.81.ConclusionIn patients who underwent TME, a discharge strategy based on CRP monitoring significantly decreased LHS without increasing morbidity, mortality or rehospitalization rates.
On the effects of antitrust policy intervention in pricing strategies in a distribution channel
Authors: Yenipazarli Arda 
Published: February 2021

AbstractIn this article, we examine the economic and welfare ramifications of antitrust policy intervention in primary‐ and secondary‐line price discrimination in a distribution channel where downstream retailers are vertically related through a strategic upstream manufacturer. Particularly, we focus on a distribution channel where a manufacturer sells his product through retailers in two asymmetric markets. The markets are asymmetric along two dimensions: One exhibits a higher demand/profit potential than does the other; and one is a competitive market where two retailers engage in imperfect price competition, whereas the other is a captive market monopolized by one of the retailers. We characterize the effect of antitrust policy intervention in each form of third‐degree price discrimination on the pricing and selling mechanisms of channel members, consumers, and the channel profits (and hence on the total welfare) for varying degrees of asymmetry on demand potential between the two markets and the extent of product substitutability. We show that under practical demand and competition conditions, contrary to prior literature, antitrust policy intervention in secondary‐line discrimination always benefits the local retailer (the disfavored customer of the manufacturer) and yet is apt to result in a lose–win or lose–lose outcome in addition to a win–win outcome for the channel and society. Second, antitrust policy intervention in primary‐line discrimination so as to protect a localized retailer from the selective price cuts of a chain‐store retailer (rather than to protect competition) can actually result in a win–win outcome. Third, in the absence of antitrust policy intervention, consumers are always harmed by (discriminatory) pricing practices employed in a channel. Those and other findings contribute to the intense debate over the merits and goals of antitrust policy intervention in third‐degree price discrimination in distribution channels by shedding some light on the contractual relationships between manufacturers and retailers and economic forces at play.
Who aspires to higher education? Axes of inequality, values of education and higher education aspirations in secondary schools in Luxembourg and the Swiss Canton of Bern
Authors: Hadjar Andreas , Scharf Jan , Hascher Tina 
Published: February 2021

AbstractThis article reports a study that investigated secondary school students’ higher education aspirations (towards university studies, ISCED 6 and above) and how these differ between student groups as well as how these are impacted by values of education. Panel data of more than 300 secondary school students in two countries, Luxembourg and Switzerland (the Swiss Canton of Bern) was analysed. Schools are structured differently in the education systems of Luxembourg and the Swiss Canton of Bern. The results of our analysis show that students in the Luxembourgish sample more often aspire to higher education than in the Swiss sample. Disparities in higher education aspirations were also more pronounced in the Luxembourgish sample, boys and students from families of low socio‐economic status (SES) were less likely to aspire to higher education. While the effects of values of education are generally scarce, stimulation in terms of anticipated enjoyment and interest derived from participation in higher education seems to have a positive effect on higher education aspirations.
Discovery of flower‐visiting fishflies: Adult Neochauliodes amamioshimanus (Megaloptera: Corydalidae) nocturnally forages on Schima wallichii ssp. noronhae trees
Authors: Sugiura Naoto , Miyazaki Satoshi 
Published: February 2021

AbstractIn the Megaloptera (alderflies, dobsonflies, and fishflies), a small taxon usually known for being aquatic insects, the bionomics of terrestrial adults in natural habitats remains largely unexplored. Here, we report the flower‐visiting habits of the adult nocturnal fishfly Neochauliodes amamioshimanus on Amami Island, the central Ryukyus, Japan. Field observations and examination of fishfly excrement revealed that the fishfly species routinely visits the carpenter bee‐pollinated tree Schima wallichii ssp. noronhae for pollen. For adults, pollen is probably an important food source because the excrement samples from both sexes frequently contained pollen. Furthermore, the intrafloral behavior suggested that flower‐visiting individuals also ingest nectar. Although some alderfly species have been presumed to visit flowers for food ingestion, the present study is the first to fully document floral resource utilization by megalopterans in natural habitats. We also discuss whether the fishfly species serves as a supplementary pollinator for the trees while foraging at night.