bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot trial of remote monitoring to prevent malnutrition after hepatopancreatobiliary surgery
Authors: Allenson Kelvin , Turner Kea , Gonzalez Brian D. , Gurd Erin , Zhu Sarah , Misner Nicole , Chin Alicia , Adams Melissa , Cooper Laura , Nguyen Diana , Naffouje Samer , Castillo Diana L. , Kocab Maria , James Brian , Denbo Jason , Pimiento Jose M. , Malafa Mokenge , Powers Benjamin D. , Fleming Jason B. , Anaya Daniel A. , Hodul Pamela J. 
Published: December 2021

Abstract
Background
Patients undergoing hepatopancreatobiliary (HPB) surgery, such patients with pancreatic, periampullary, and liver cancer, are at high risk for malnutrition. Malnutrition increases surgical complications and reduces overall survival. Despite its severity, there are limited interventions addressing malnutrition after HPB surgery. The aim of this pilot trial was to examine feasibility, acceptability, usability, and preliminary efficacy of a remote nutrition monitoring intervention after HPB surgery.

Methods
Participants received tailored nutritional counseling before and after surgery at 2 and 4 weeks after hospital discharge. Participants also recorded nutritional intake daily for 30 days, and these data were reviewed remotely by registered dietitians before nutritional counseling visits. Descriptive statistics were used to describe study outcomes.

Results
All 26 patients approached to participate consented to the trial before HPB surgery. Seven were excluded after consent for failing to meet eligibility criteria (e.g., did not receive surgery). Nineteen participants (52.6% female, median age = 65 years) remained eligible for remote monitoring post-surgery. Nineteen used the mobile app food diary, 79% of participants recorded food intake for greater than 80% of study days, 95% met with the dietitian for all visits, and 89% were highly satisfied with the intervention. Among participants with complete data, the average percent caloric goal obtained was 82.4% (IQR: 21.7).

Conclusions
This intervention was feasible and acceptable to patients undergoing HPB surgery. Preliminary efficacy data showed most participants were able to meet calorie intake goals. Future studies should examine intervention efficacy in a larger, randomized controlled trial.

Trial registration
Clinicaltrials.gov. Registered 16 September 2019, https://clinicaltrials.gov/ct2/show/NCT04091165.
Fermented rye with Agaricus subrufescens and mannan-rich hydrolysate based feed additive to modulate post-weaning piglet immune response
Authors: de Groot Nienke , Fariñas Fernando , Fabà Lluís , Hambrecht Ellen , Cabrera-Gómez Carolina G. , Pallares Francisco J. , Ramis Guillermo 
Published: December 2021

Abstract
Background
The process of weaning in piglets is often associated with an increased inflammation response in the intestine and compromised intestinal integrity and morphology, favoring a delay in intestinal maturation and a predisposal to diseases. Research has shown the potential of different nutritional strategies to reduce the production of pro-inflammatory cytokines, with the main goal to manipulate health and performance of pigs. Promising examples of nutritional strategies are fungal fermented products and their derivatives which are described to contain several compounds that may play a role in gastrointestinal health and pathogenic bacteria control. Products from Agaricus subrufescens mushroom are reported to contain prophylactic and therapeutic properties including antimicrobial and immunomodulatory properties.

Results
This study analysed the post-weaning immune status in intestinal tissue and blood of piglets, with the objective to evaluate the gastrointestinal health and immune modulation response induced by a blend of mannan-rich hydrolyzed copra meal and fermented rye with A. subrufescens. Intestinal histomorphology demonstrated a villus height reduction in jejunum and increase in ileum on day 15, while increased villous height in jejunum and ileum on day 30. The results showed that in post-weaning piglets, the feed additive stimulates an immunomodulation effect most evident at 15 days post-weaning, with significant lower expression of cytokines Interferon (IFN) γ, Interleukin (IL) 1α, IL-1β, IL-6, IL-8, IL-10 and Transforming Growth Factor (TGF) β in jejunum, accompanied with an increase in peripheral blood mononuclear cells (PBMC) cytokine gene expression of IL-1β, IL-6, IL-8, IL-10, IL-12p35 (IL-12α), IL-12p40 (IL-12β), Tumor Necrosis Factor (TNF) α, IFN-α, and TGF-β. In piglets fed the feed additive, the quantity of Immunoglobulin (Ig) A producing cells in jejunum, ileum was reduced on day 15 and 30 post-weaning, and on day 30 and 45 post-weaning in colon tissue. Natural Killer (NK) cells count in blood were increased on day 15 post-weaning in the piglets fed the feed additive.

Conclusion
This study implies the potential of the blend including mannan-rich hydrolyzed copra meal and fermented rye with A. subrufescens on immune modulation in the intestine of post-weaning piglets.
Egyptian pediatric clinical practice guidelines for urinary tract infections in infants and children (evidence based)
Authors: Moustafa Bahia H. , Rabie Moftah M. , El Hakim Ihab Z. , Badr Ahmed , El Balshy Moustafa , Kamal Nesreen Mohamad , Ali Ragia Marei ,   Pediatric Nephrology Work Group, Moustafa Bahia H. , Rabie Moftah M. , El Hakim Ihab Z. , Badr Ahmed , El Balshy Moustafa , Ali Ragia Marei 
Published: December 2021

Abstract
Background
National evidence-based recommendations for diagnosis, treatment, imaging, and follow-up in urinary tract infection are crucial being a major health problem in pediatrics. Every region should follow international recommendations with respect to the disease local profile and available facilities for that area.

Methods
Based on AGREE II (the assessment tool of practice guidelines), Egyptian CGLs used *American Academy Pediatrics, *European Association Urology, European Society Pediatric Urology, and *Asian Association Urinary tract infections as its evidence-based references. Health questions were listed for evidence base answers adopted from selected CGLs after their permission. Key statements were approved by all members and further approved by the Egyptian Pediatric Guidelines Committee after local and international external peer reviewing.

Results
(1) Diagnosis recommendations: Urine culture with diagnostic colony counts is essential for diagnosis. Catheter samples are important for critical cases and non-toilet-trained cases especially when they show significant bacteriuria and pyuria. (2) Treatment plan included areas of debate as choice of antibiotic, oral versus intravenous, duration, antibiotic prophylaxis considering age, disease severity, recurrence, + risk factors, and imaging reports. (3) Imaging recommendations were tailored to suit our community. Renal bladder ultrasound is important for children with febrile UTI, due to the high prevalence of congenital anomalies of the kidney and urinary tract, paucity of prenatal ultrasound, and lack of medical documentation to reflect previously diagnosed UTI or US reports. We recommend renal isotopic scan and voiding cystography for serious presentation, high-risk factors, recurrence, and abnormal US. (4) Urological consultation is recommended: in urosepsis or obstruction, male infants < 6 months. Acute basal DMSA is recommended in congenital renal hypodysplasia. Six months post-infection, US and DMSA are recommended in severe pyelonephritis and vesico-ureteric reflux, where those with abnormal US or DMSA or both should have voiding cystography. (5) Follow-up recommendations include family orientation with hazards of noncompliance and monitoring at pregnancy.

Conclusion
Diagnosis and treatment show strong recommendations. Imaging depends on patient assessment. Referral to a pediatric nephrologist and urologist in complicated cases is crucial. Follow-up after the age of 16 years in adult clinics is important.
Automated quantification of COVID-19 pneumonia severity in chest CT using histogram-based multi-level thresholding segmentation
Authors: Yousef Hazem Abuzeid , Moussa Ehab Mansour Mohmad , Abdel-Razek Mohamed Zidan Mohamed , El-Kholy Maha Mohamed Said Ahmed , Hasan Lamiaa Hasan Shaaban , El-Sayed Alaa El-Din Abdel-Moneim , Saleh Medhat Araby Khalil , Omar Mohamed Karim Mahmoud 
Published: December 2021

Abstract
Background
Chest computed tomography (CT) has proven its critical importance in detection, grading, and follow-up of lung affection in COVID-19 pneumonia. There is a close relationship between clinical severity and the extent of lung CT findings in this potentially fatal disease. The extent of lung lesions in CT is an important indicator of risk stratification in COVID-19 pneumonia patients. This study aims to explore automated histogram-based quantification of lung affection in COVID-19 pneumonia in volumetric computed tomography (CT) images in comparison to conventional semi-quantitative severity scoring. This retrospective study enrolled 153 patients with proven COVID-19 pneumonia. Based on the severity of clinical presentation, the patients were divided into three groups: mild, moderate and severe. Based upon the need for oxygenation support, two groups were identified as follows: common group that incorporated mild and moderate severity patients who did not need intubation, and severe illness group that included patients who were intubated. An automated multi-level thresholding histogram-based quantitative analysis technique was used for evaluation of lung affection in CT scans together with the conventional semi-quantitative severity scoring performed by two expert radiologists. The quantitative assessment included volumes, percentages and densities of ground-glass opacities (GGOs) and consolidation in both lungs. The results of the two evaluation methods were compared, and the quantification metrics were correlated.

Results
The Spearman’s correlation coefficient between the semi-quantitative severity scoring and automated quantification methods was 0.934 (p < 0.0001).

Conclusions
The automated histogram-based quantification of COVID-19 pneumonia shows good correlation with conventional severity scoring. The quantitative imaging metrics show high correlation with the clinical severity of the disease.
Phase transition to chimera state in two populations of oscillators interacting via a common external environment
Authors: Ri Jong-Sang , Jang Hyok , Choe Chol-Ung 
Published: December 2021

Abstract
We consider two populations of coupled oscillators, interacting with each other through a common external environment. The external environment is synthesized by the contributions from all oscillators of both populations. Such indirect coupling via an external medium arises naturally in many fields, e.g., dynamical quorum sensing in coupled biological and chemical systems. We analyze the existence and stability of a variety of stationary states on the basis of the Ott-Antonsen reduction method, which reveals that the interaction via an external environment gives rise to unusual collective behaviors such as the uniform drifting, non-uniform drifting and chimera states. We present a complete bifurcation diagram, which provides the underlying mechanism of the phase transition towards chimera state with the route of incoherence

uniform drift

non-uniform drift

chimera.
The linearity of the master stability function
Authors: Ramadoss Janarthanan , Rajagopal Karthikeyan , Natiq Hayder , Hussain Iqtadar 
Published: December 2021

AbstractThe master stability function (MSF) is a tool to evaluate the local stability of the synchronization in coupled oscillators. Computing the MSF of a network of a specific oscillator results in a curve whose shape is dependent on the nodes' dynamics, network topology, coupling function, and coupling strength. This paper calculates the MSF of networks of two diffusively coupled oscillators by considering different single variable and multi-variable couplings. Then, the linearity of the MSF is investigated by fitting a straight line to the MSF curve, and the root mean square error is obtained. It is observed that the multi-variable coupling with equal coefficients on all variables results in a linear MSF regardless of the dynamics of the nodes.
Geometric measure of entanglement of multi-qubit graph states and its detection on a quantum computer
Authors: Gnatenko Kh. P. , Susulovska N. A. 
Published: December 2021

Abstract
Multi-qubit graph states generated by the action of controlled phase shift operators on a separable quantum state of a system, in which all the qubits are in arbitrary identical states, are examined. The geometric measure of entanglement of a qubit with other qubits is found for the graph states represented by arbitrary graphs. The entanglement depends on the degree of the vertex representing the qubit, the absolute values of the parameter of the phase shift gate and the parameter of state the gate is acting on. Also the geometric measure of entanglement of the graph states is quantified on the quantum computer

. The results obtained on the quantum device are in good agreement with analytical ones.
Memory Dysfunction
Authors: Fernandez-Romero Roberto , Spica D. Malcolm 
Published: December 2021

ABSTRACT

PURPOSE OF THE REVIEW
This article provides a practical overview of the diagnostic process for patients with memory dysfunction through exploration of the anatomic, physiologic, and psychological aspects of human memory.

RECENT FINDINGS
As updated methods become available to neurologists, the ability to accurately identify and treat patients with memory disorders evolves. An appreciation of current concepts in the anatomic, physiologic, and psychological aspects of memory, combined with a rational application of everyday tools (such as clinical examination, bedside testing, standardized cognitive screening, and formal neuropsychological examination), allows the clinician to identify possible etiologies and track longitudinal changes in functional memory status. Recent findings regarding the interactions of limbic, anterior temporal, primary sensory, parietal, and dorsal prefrontal structures shed new light on the putative classifications of procedural and declarative memory and their subfunctions.

SUMMARY
An understanding of memory profiles pertaining to registration, encoding, consolidation, storage, and retrieval, as well as methods to assess those functions, facilitates the clinician’s identification of underlying pathology and affected cerebral territories. The memory profile must be appreciated in the context of the entire individual, including possible confounds of comorbid conditions, psychiatric disorders, and normal healthy aging.
Mood Disorders
Authors: Datta Shae , Suryadevara Uma , Cheong Josepha 
Published: December 2021

ABSTRACT

PURPOSE OF REVIEW
This comprehensive review of mood disorders brings together the past and current literature on the diagnosis, evaluation, and treatment of the depressive and bipolar disorders. It highlights the primary mood disorders and secondary neurologic causes of mood disorders that are commonly encountered in a clinical setting. As the literature and our understanding evolve, recent additions to the current literature are important to bring forth to the readers.

RECENT FINDINGS
Advancements in clinical medicine have strengthened our understanding of the associations of neurologic and psychiatric diseases. This article highlights the medications frequently used with newly identified mood disorders and the common side effects of these medications. A paradigm shift has moved toward newer treatment modalities, such as the use of ketamine, repetitive transcranial magnetic stimulation, and complementary and alternative medicine. The risks and benefits of such therapies, along with medications, are reviewed in this article.

SUMMARY
Mood disorders are extraordinarily complex disorders with significant association with many neurologic disorders. Early identification of these mood disorders can prevent significant morbidity and mortality associated with them. With further expansion of pharmacologic options, more targeted therapy is possible in improving quality of life for patients.
Cyclophilin A regulates the apoptosis of A549 cells by stabilizing Twist1 protein
Authors: Wu Yaru , Ma Zhenling , Zhang Yanyan , Zhang Min , Zhang Wenwen , Zhang Menghao , Shi Xixi , Li Wenqing , Liu Wei 
Published: December 2021

ABSTRACT
Cyclophilin A (CypA, also known as PPIA) is an essential member of the immunophilin family. As an intracellular target of the immunosuppressive drug cyclosporin A (CsA) or a peptidyl-prolyl cis/trans isomerase (PPIase), it catalyzes the cis-trans isomerization of proline amidic peptide bonds, through which it regulates a variety of biological processes, such as intracellular signaling, transcription and apoptosis. In this study, we found that intracellular CypA enhanced Twist1 phosphorylation at Ser68 and inhibited apoptosis in A549 cells. Mechanistically, CypA could mediate the phosphorylation of Twist1 at Ser68 via p38 mitogen-activated protein kinase (also known as MAPK14), which inhibited its ubiquitylation-mediated degradation. In addition, CypA increased interaction between Twist1 and p65 (also known as RELA), as well as nuclear accumulation of the Twist1-p65 complex, which regulated Twist1-dependent expression of CDH1 and CDH2. Our findings collectively indicate the role of CypA in Twist1-mediated apoptosis of A549 cells through stabilizing Twist1 protein.
Comparative sound detection abilities of four decapod crustaceans
Authors: Radford Craig A. , Tay Kevin , Goeritz Marie L. 
Published: December 2021

ABSTRACT
Sound perception and detection in decapod crustaceans is surprisingly poorly understood, even though there is mounting evidence for sound playing a critical role in many life history strategies. The suspected primary organ of sound perception is the paired statocysts at the base of the first antennal segment. To better understand the comparative sound detection of decapods, auditory evoked potentials were recorded from the statocyst nerve region of four species (Leptograpsus variegate, Plagusia chabrus, Ovalipes catharus, Austrohelice crassa) in response to two different auditory stimuli presentation methods, shaker table (particle acceleration) and underwater speaker (particle acceleration and pressure). The results showed that there was significant variation in the sound detection abilities between all four species. However, exposure to the speaker stimuli increased all four species sound detection abilities, in terms of both frequency bandwidth and sensitivity, compared with shaker table-derived sound detection abilities. This indicates that there is another sensory mechanism in play as well as the statocyst system. Overall, the present research provides comparative evidence of sound detection in decapods and indicates underwater sound detection in this animal group was even more complex than previously thought.
Bipolar Disorder and Athletes: A Narrative Review
Authors: Daley Mary M. , Reardon Claudia L. 
Published: December 2021

Abstract
Bipolar disorder is a diagnosis with immense lifelong implications that affects 1% to 2% of the general population. It typically presents during late adolescence and early adulthood, which often coincides with the age of peak athletic performance and a limited window of opportunity to compete at the highest levels of sport. Understanding the nature and course of the illness, as well as the effects that pharmacological treatment can have on an athlete, can be extremely beneficial for sports medicine physicians, particularly as many young athletes may not yet be diagnosed and/or adequately treated. Bipolar disorder is an incredibly complex and challenging diagnosis, but the ability to identify symptoms and intervene early is invaluable. The aim of this review is to summarize the available evidence and to highlight relevant risk factors, diagnostic features, management, and potential complications pertaining to the athletic population.
Posttraumatic Stress Disorder in Elite Athletes
Authors: Lynch James H. 
Published: December 2021

Abstract
Posttraumatic stress disorder (PTSD), which may develop following exposure to severe trauma, can occur in all people at any age. PTSD affects approximately 10 million Americans, with an incidence of approximately 3.5% diagnosed every year. Elite athletes are not immune to posttraumatic stress. While difficult to precisely quantify, an estimated 1 in 8 elite athletes suffers from PTSD. Because of its complex presentation, PTSD can be challenging to diagnose and effectively treat in athletes. Several barriers unique to elite athletes exist which may inadvertently delay or prevent access to the appropriate clinical experts. Several best practice models for mental health screening in elite athletes have been developed in the past decade. Treatment of PTSD in the athlete population is similar to trauma-informed treatment in the general population, but should involve the athlete’s multidisciplinary team of clinical experts to account for unique demands and preferences in the context of sport.
СУБЪЕКТНЫЕ ДЕЙСТВИЯ В САМООПРЕДЕЛЕНИИ МОЛОДЕЖИ
Authors: Finogenova Olga N. , Nurgaleev Vladimir S. 
Published: December 2021

Целью исследования является изучение механизмов самоопределения личности в процессе реализации субъектных действий. Предложена рабочая структурно-динамическая модель самоопределения. Введено понятие субъектного действия как авторского, внутренне мотивированного действия личности. Поставлена задача исследования связи субъектных действий с ценностно-смысловыми и операциональными аспектами самоопределения.
Методы эмпирического исследования «Диагностика мотивационной структуры личности» В.Э. Мильмана и опрос «Что вы уже делали самостоятельно» размещенные в Google-forms.
В результате исследования установлены различия в мотивах студентов, имеющих и не имеющих опыт реализации субъектных действий. Получены данные о количественных и качественных различиях самоопределения студентов, имеющих и не имеющих субъектные действия. Студенты, осуществляющие субъектные действия, отличаются активностью, самоэффективностью, уверенностью в своих возможностях, умением ценить возможности, предоставляемые им обучением, стремлением к личностному росту и самоактуализации. Студенты, не осуществляющие субъектных действий, отличаются преобладанием аффилиативных и витальных ценностей.
На основании выявленного влияния субъектных действий на самоопределение личности сформированы гипотезы о возможности психологического сопровождения самоопределения в двух сферах – ценностно-смысловой и операциональной. Тактика сопровождения основана на идее стимулирования субъекта к реализации субъектных действий, характеризующихся активностью субъекта, осмысленностью и наличием объективно значимого результата действия.