bluuebunny/crossref_metadata_2025_split huggingface dataset:
ɑ-Lactalbumin Improves Sleep and Recovery after Simulated Evening Competition in Female Athletes
Authors: MILES KATHLEEN H. , CLARK BRAD , FOWLER PETER M. , GRATWICKE MADELEINE J. , MARTIN KRISTY , WELVAERT MARIJKE , MILLER JOANNA , PUMPA KATE L. 
Published: July 2021

ABSTRACT

Purpose
This study aimed to determine the efficacy of α-lactalbumin (A-LAC) supplementation for improving sleep and performance recovery after simulated evening competition in female athletes.

Methods
Sixteen trained women (mean ± SD: age, 27 ± 7 yr; mass, 62 ± 10 kg; stature, 167 ± 8 cm) participated in this randomized double-blind three-arm crossover study. Participants completed a simulated evening competition before consuming either an A-LAC whey protein, whey protein placebo (PLA), or water control (CON) beverage. Sleep was monitored via polysomnography, and participants completed a series of physical, cognitive, and perceptual assessments before, and 14 and 24 h after simulated competition.

Results
Non–rapid eye movement stage 2 sleep increased after competition in A-LAC (pre, 199 ± 44 min; post, 212 ± 37 min) but decreased in CON (pre, 228 ± 43 min; post, 195 ± 40 min) and PLA (pre, 224 ± 25 min; post, 211 ± 35 min; P = 0.012). In addition, Yo-Yo Intermittent Recovery Test Level 1 distance improved over time in A-LAC (baseline, 664 ± 332 m; 14 h post, 667 ± 326 m; 24 h post, 781 ± 427 m) compared with CON (baseline, 741 ± 366 m; 14 h post, 648 ± 351 m; 24 h post, 720 ± 407 m) and PLA (baseline, 763 ± 394 m; 14 h post, 636 ± 366 m; 24 h post, 720 ± 396 m; P < 0.001).

Conclusions
The findings indicate that A-LAC supplementation may be useful for retaining some sleep characteristics after evening competition, leading to improved physical performance in female athletes.
The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol
Authors: Matterne Uwe , Tischer Christina , Wang Jiancong , Knüttel Helge , Genuneit Jon , Perkin Michael , Apfelbacher Christian 
Published: July 2021

Background: Research in early childhood allergy prevention (ECAP) is flourishing and new intervention strategies have proven to be promising. Due to the dynamic nature of ECAP, gaps between what is known and how guidelines inform practice are likely. A living systematic review (LSR) can narrow this gap by incorporating new evidence as it becomes available. No efficacy comparisons across various ECAP interventions for similar outcomes have been carried out. Networks of randomised clinical trials can be evaluated in the context of a network meta-analysis (NMA). We aim to establish a LSR on the efficacy and safety of any intervention investigated in randomised controlled trials (RCT) to prevent the occurrence of allergic sensitisation (AS), symptoms or diagnoses of allergic diseases in infancy and early childhood (0-3 years). Methods: A baseline SR will synthesise the evidence from existing SRs of RCTs as well as RCTs not yet considered in these. After completion of the baseline SR we propose to conduct a LSR. Using this methodology, we aim to undertake constant evidence surveillance, three-monthly search updates, and review updates every three months, should new evidence emerge. Conclusions: The ECAP evidence landscape has undergone dramatic transformations and this process is likely to continue. As a response to this, a LSR offers the potential to allow more timely synthesis of new evidence as it emerges. Long gaps between updates of SRs makes it harder for guidelines and recommendations to be up to date. Users of information, such as parents, may be confused if they encounter new evidence that is not part of a trusted guideline. A LSR approach allows us to continuously search the literature and update the evidence-base of existing ECAP interventions resulting in a decreased timespan from evidence accrual to informing clinical practice.
Perspectives on public health interventions in the management of the COVID-19 pandemic in Thailand
Authors: Pan-ngum Wirichada , Poomchaichote Tassawan , Peerawaranun Pimnara , Kulpijit Natinee , Osterrieder Anne , Waithira Naomi , Mukaka Mavuto , Naemiratch Bhensri , Chanviriyavuth Rita , Asarath Supa-at , Ruangkajorn Supanat , Kannika Noppadon , Cheah Phaik Yeong 
Published: July 2021

Background: Any government needs to react quickly to a pandemic and make decisions on healthcare interventions locally and internationally with little information regarding the perceptions of people and the reactions they may receive during the implementation of restrictions. Methods: We report an anonymous online survey in Thailand conducted in May 2020 to assess public perceptions of three interventions in the Thai context: isolation, quarantine and social distancing. A total of 1,020 participants, of whom 52% were women, responded to the survey. Results: Loss of income was the main concern among respondents (>80% for all provinces in Thailand). Traditional media and social media were important channels for communication during the pandemic. A total of 92% of respondents reported that they changed their social behaviour even before the implementation of government policy with 94% reporting they performed social distancing, 97% reported using personal protective equipment such as masks and 95% reported using sanitizer products. Conclusions: This study showed a high level of compliance from individuals with government enforced or voluntarily controls such as quarantine, isolation and social distancing in Thailand. The findings from this study can be used to inform future government measures to control the pandemic and to shape communication strategies.
Live-Lançamento de livro do Prof. Dr. Roberto Sidnei Macedo
Authors: Amaral Mirian Maia do 
Published: July 2021

Essa resenha versa sobre a live de lançamento do livro “A pesquisa como heurística, ato de currículo e formação universitária: experiências transingulares com o método em ciências da educação”. Campinas, SP: Pontes Editores, 2020, de autoria de Roberto Macedo, na qual o autor discute a pesquisa universitária, pautada num rigor outro e plural,e transversalizada por compreensões curriculares, inspirações heurísticas e implicação formacional, baseadas em suas experiências, consolidadas no Grupo de pesquisa Formacce, e inspiradas no método etnográfico.
Effect of temperament on recovery in isoflurane-anaesthetised horses
Authors: Bryant Helen , Loomes Kate , Dugdale Alex 
Published: July 2021

Background:Recovery is a crucial phase of equine anaesthesia and factors influencing recovery quality are an active area of research.Aim:To investigate the effect of temperament on recovery score after isoflurane-anaesthesia in 30 adult horses undergoing elective surgery.Methods:Two veterinarians used a numerical rating scale to score each horse's response to five tests as a gauge of temperament. Owners used a numerical rating scale to score their horse's temperament according to seven behaviour-related questions. Horses underwent elective surgery under general anaesthesia using a standardised protocol. Recovery was recorded and scored by a blinded assessor using the simple descriptive scale for scoring recovery (R1) and the Edinburgh system (R2).Findings:There was no correlation between veterinarian or owner-assessed temperament and recovery score. Veterinary-assessed temperament score was negatively correlated with pre-induction romifidine and total romifidine dose. Both recovery scores were negatively correlated with anaesthetic duration and R1 was positively correlated with time to first movement in recovery.Conclusions:Temperament did not influence recovery score in our population of horses.
The orthopaedic waiting list crisis
Authors: Hampton Matthew , Riley Ella , Garneti Naren , Anderson Alexander , Wembridge Kevin 
Published: July 2021

AimsDue to widespread cancellations in elective orthopaedic procedures, the number of patients on waiting list for surgery is rising. We aim to determine and quantify if disparities exist between inpatient and day-case orthopaedic waiting list numbers; we also aim to determine if there is a ‘hidden burden’ that already exists due to reductions in elective secondary care referrals.MethodsRetrospective data were collected between 1 April 2020 and 31 December 2020 and compared with the same nine-month period the previous year. Data collected included surgeries performed (day-case vs inpatient), number of patients currently on the orthopaedic waiting list (day-case vs inpatient), and number of new patient referrals from primary care and therapy services.ResultsThere was a 52.8% reduction in our elective surgical workload in 2020. The majority of surgeries performed in 2020 were day case surgeries (739; 86.6%) with 47.2% of these performed in the independent sector on a ‘lift and shift’ service. The total number of patients on our waiting lists has risen by 30.1% in just 12 months. As we have been restricted in performing inpatient surgery, the inpatient waiting lists have risen by 73.2%, compared to a 1.6% rise in our day-case waiting list. New patient referral from primary care and therapy services have reduced from 3,357 in 2019 to 1,722 in 2020 (49.7% reduction).ConclusionThis study further exposes the increasing number of patients on orthopaedic waiting lists. We observed disparities between inpatient and day-case waiting lists, with dramatic increases in the number of inpatients on the waiting lists. The number of new patient referrals has decreased, and we predict an influx of referrals as the pandemic eases, further adding to the pressure on inpatient waiting lists. Robust planning and allocation of adequate resources is essential to deal with this backlog. Cite this article: Bone Jt Open 2021;2(7):530–534.
Primary total hip arthroplasty outcomes in octogenarians
Authors: Zak Stephen Gerard , Lygrisse Katherine , Tang Alex , Meftah Morteza , Long William J. , Schwarzkopf Ran 
Published: July 2021

Aims As our population ages, the number of octogenarians who will require a total hip arthroplasty (THA) rises. In a value-based system where operative outcomes are linked to hospital payments, it is necessary to assess the outcomes in this population. The purpose of this study was to compare outcomes of elective, primary THA in patients ≥ 80 years old to those aged < 80. Methods A retrospective review of 10,251 consecutive THA cases from 2011 to 2019 was conducted. Patient-reported outcome (PRO) scores (Hip disability and Osteoarthritis Outcome Score (HOOS)), as well as demographic, readmission, and complication data, were collected. Results On average, the younger cohort (YC, n = 10,251) was a mean 61.60 years old (SD 10.71), while the older cohort (OC, n = 609) was 84.25 years old (SD 3.02) (p < 0.001). The OC had greater surgical risk based on their higher mean American Society of Anesthesiologists (ASA) scores (2.74 (SD 0.63) vs 2.30 (SD 0.63); p < 0.001) and Charlson Comorbidity Index (CCI) scores (6.26 (SD 1.71) vs 3.87 (SD 1.98); p < 0.001). While the OC stayed in the hospital longer than the YC (mean 3.5 vs 2.5 days; p < 0.001), there were no differences in 90-day emergency visits (p = 0.083), myocardial infarctions (p = 0.993), periprosthetic joint infections (p = 0.214), dislocations (p = 0.993), or aseptic failure (p = 0.993). The YC was more likely to be readmitted within 90 days (3.88% vs 2.18%, Β = 0.57; p = 0.048). There were no observed differences in 12-week (p = 0.518) or one-year (p = 0.511) HOOS scores. Conclusion Although patients ≥ 80 years old have a greater number of comorbidities than younger patients, they had equivalent perioperative complication rates and PRO scores. This study demonstrates the safety and success of elective THA in octogenarians. Cite this article: Bone Jt Open 2021;2(7):535–539.
Optical charge state manipulation of divacancy spins in silicon carbide under resonant excitation
Authors: Wang Jun-Feng , Zhou Ji-Yang , Li Qiang , Yan Fei-Fei , Yang Mu , Lin Wu-Xi , Hao Ze-Yan , Li Zhi-Peng , Liu Zheng-Hao , Liu Wei , Sun Kai , Wei Yu , Tang Jian-Shun , Xu Jin-Shi , Li Chuan-Feng , Guo Guang-Can 
Published: July 2021

Spin defects in silicon carbide (SiC) have attracted much attentions in various quantum technologies. In this work, we study the optical manipulation of charge state and coherent control of multifold divacancy spins ensemble in SiC under resonant excitation. The results reveal that the resonantly excited divacancy ensemble counts have dozens of enhancements by repumping a higher-energy laser. Moreover, it has a similar optimal repump laser wavelength of around 670 nm for multiple divacancies. On the basis of this, the optically detected magnetic resonance (ODMR) experiment shows that repump lasers with different wavelengths do not affect the ODMR contrast and line width. In addition, the repump lasers also do not change the divacancy spins’ coherence times. The experiments pave the way for using the optimal repump excitation method for SiC-based quantum information processing and quantum sensing.
Estimating the effect of moving meat-free products to the meat aisle on sales of meat and meat-free products: A non-randomised controlled intervention study in a large UK supermarket chain
Authors: Piernas Carmen , Cook Brian , Stevens Richard , Stewart Cristina , Hollowell Jennifer , Scarborough Peter , Jebb Susan A. 
Published: July 2021

Background
Reducing meat consumption could bring health and environmental benefits, but there is little research to date on effective interventions to achieve this. A non-randomised controlled intervention study was used to evaluate whether prominent positioning of meat-free products in the meat aisle was associated with a change in weekly mean sales of meat and meat-free products.

Methods and findings
Weekly sales data were obtained from 108 stores: 20 intervention stores that moved a selection of 26 meat-free products into a newly created meat-free bay within the meat aisle and 88 matched control stores. The primary outcome analysis used a hierarchical negative binomial model to compare changes in weekly sales (units) of meat products sold in intervention versus control stores during the main intervention period (Phase I: February 2019 to April 2019). Interrupted time series analysis was also used to evaluate the effects of the Phase I intervention. Moreover, 8 of the 20 stores enhanced the intervention from August 2019 onwards (Phase II intervention) by adding a second bay of meat-free products into the meat aisle, which was evaluated following the same analytical methods.
During the Phase I intervention, sales of meat products (units/store/week) decreased in intervention (approximately −6%) and control stores (−5%) without significant differences (incidence rate ratio [IRR] 1.01 [95% CI 0.95–1.07]. Sales of meat-free products increased significantly more in the intervention (+31%) compared to the control stores (+6%; IRR 1.43 [95% CI 1.30–1.57]), mostly due to increased sales of meat-free burgers, mince, and sausages. Consistent results were observed in interrupted time series analyses where the effect of the Phase II intervention was significant in intervention versus control stores.

Conclusions
Prominent positioning of meat-free products into the meat aisle in a supermarket was not effective in reducing sales of meat products, but successfully increased sales of meat-free alternatives in the longer term.
A preregistered protocol (https://osf.io/qmz3a/) was completed and fully available before data analysis.
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018
Authors: Finn Talya , Babushkin Frida , Geller Keren , Alexander Hanna , Paikin Svetlana , Lellouche Jonathan , Atiya-Nasagi Yafit , Cohen Regev 
Published: July 2021

Introduction
Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined.

Methods
A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Serum samples from suspected cases were preliminary tested by a qualitative enzyme immunoassay (EIA). Confirmatory testing at the reference laboratory used an indirect immunofluorescence assay (IFA). Positive cases were defined as fever with at least one other symptom and accepted laboratory criteria such as a single-phase II immunoglobulin G (IgG) antibody titer ≥1:200. Cases not fulfilling these criteria and in which acute Q fever was excluded, served as a control group.

Results
Between January 2012 and May 2018, 484 patients tested positive. After confirmatory testing, 65 (13.4%) were positive for acute Q fever (with requisite clinical picture), 171 (35.3%) were definitely not infected, the remaining 248 were excluded because of past/chronic/undetermined infection. The average age was 58 years and 66% were males. Most resided in urban areas with rare animal exposure. Pneumonia was seen in 57% of cases and a combination with headache/hepatitis was highly suggestive of acute Q fever diagnosis. Syncope/presyncope, fall and arthritis were more common in acute Q fever cases. Laboratory indexes were similar to the control group, except for erythrocyte sedimentation rate (ESR) which was more common and higher in the study group.

Conclusion
Acute Q fever in the Sharon district could be better diagnosed by using a syndromic approach in combination with improved rapid diagnostic testing.
Knowledge, attitude and preventive practice towards COVID-19 and associated factors among outpatient service visitors at Debre Markos compressive specialized hospital, north-west Ethiopia, 2020
Authors: Feleke Bekele Taye , Wale Mengistu Zelalem , Yirsaw Mesenbet Terefe 
Published: July 2021

Background
COVID-19 is an emerging infectious disease which is a major public health problem worldwide. Given the serious threats imposed by COVID-19 and the absence of vaccines until August 2020, preventive measures play an essential role in reducing infection rates and controlling its spread. This shows the necessity of public adherence for preventive and control measures, which is affected by their knowledge, attitudes, and practices.

Objective
This study aimed to determine knowledge, attitude, and practice (KAP) towards COVID-19 and associated factors among outpatient service visitors, Debre Markos compressive specialized hospital, north-west,Ethiopia.

Method
Institutional-based cross-sectional study design with a systematic random sampling technique was conducted from July to August 2020. Among a total of 404 participants, 398 were recruited. Data were collected using a structured questionnaire. The data was edited, coded, and entered into Epi data version 4.6 and exported to SPSS-25 for analysis. Bivariable and multivariable logistic regression models were employed to identify factors associated with KAP. A p-value of <0.05 was considered statistically significant.

Result
The prevalence of poor knowledge, attitude and practice among the outpatient service visitors were 27.1%, 30.7% and 44%, respectively. The mean age of the participants was 33.4 ±10.9 years. Variables like; educational status, ‘‘can’t read and write” [AOR = 3.76, 95% CI (1.36–10.42), P = 0.01], read and write [AOR = 5.90, 95% CI (2.39–14.98), P = 0.01], rural residence [AOR = 3.04, 95% CI (1.43–6.46), P = 0.01] and having no television [AOR = 0.8, 95% CI (0.79–0.89), P = 0.03] were significantly associated with poor knowledge. While, educational status of “can’t read and write”, [AOR = 6.71, 95% CI (2.78–16.16), P = 0.01] and rural residence [AOR = 2.03, 95% CI (1.14–3.61), P = 0.02] were significantly associated with poor attitude. Additionally, poor knowledge, [AOR = 22.73, 95% CI (10.5–49.21), P = 0.01], rural residence [AOR = 2.08, 95% CI (1.08–4.88), P = 0.04] and having no television [AOR = 2.24, 95% CI (1.05–4.79), P = 0.01] were significantly associated with poor practice.

Conclusion
In this study, knowledge, attitude, and practice among outpatient service visitors was poor which needs targeted health education and interventions from the health professional to enhance their knowledge, attitude, and practice towards COVID-19. In parallel with this, special attention should be given for the rural community and for those with an educational status of can’t read and write.
Impact of the COVID-19 pandemic on clinical research activities: Survey of study participants and health care workers participating in a hypertension trial in Vietnam
Authors: Nguyen Hoa L. , Tran Oanh T. , Ha Duc A. , Phan Van H. , Nguyen Cuc T. , Nguyen Giang H. , Nguyen Thang T. , Chiriboga Germán , Goldberg Robert J. , Allison Jeroan J. 
Published: July 2021

Background
The COVID-19 pandemic has had a profound worldwide impact. Vietnam, a lower middle-income country with limited resources, has successfully slowed this pandemic. The objectives of this report are to explore the impact of the COVID-19 pandemic on the research activities of an ongoing hypertension trial using a storytelling intervention in Vietnam.

Methods
Data were collected in a mixed-methods study among 86 patients and 10 health care workers participating in a clinical trial designed to improve hypertension control. Several questions related to the impact of COVID-19 on patient’s daily activities and adherence to the study interventions were included in the follow-up visits. A focus group discussion was conducted among health care workers to discuss the impact of COVID-19 on research related activities.

Results
Fewer patients in the intervention group reported that they faced difficulties in adhering to prescribed study interventions, wanted to receive a call from a dedicated hotline, or have a visit from a community health worker as compared with those in the comparison group. Most study patients are willing to participate in future health research studies. When asked about the potential use of mobile phones in health research studies, fewer patients in the intervention group felt comfortable using a mobile phone for the delivery of intervention and interviews compared with those in the comparison condition. Community health workers shared that they visited patient’s homes more often than previously due to the pandemic and health care workers had to perform more virus containment activities without a corresponding increase in ancillary staff.

Conclusions
Both patients and health care workers in Vietnam faced difficulties in adhering to recommended trial interventions and procedures. Multiple approaches for intervention delivery and data collection are needed to overcome these difficulties during future health crises and enhance the implementation of future research studies.

Trial registration
ClinicalTrials.gov. Registration number: https://clinicaltrials.gov/ct2/show/NCT03590691 (registration date July 17, 2018).