bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relación entre índices antropométricos y la obesidad en personas mayores de 60 años. Estudios Europeo IN COMMON SPORT
Authors: Mollinedo-Cardalda Irimia , Pereira Karina , López-Rodríguez Adriana , Cancela-Carral José María 
Published: August 2021

Objetivo: Comprobar si el índice de masa corporal (IMC), el índice cintura-cadera (ICC), circunferencia de cintura (CCi), circunferencia de cadera (CCa) y porcentaje de grasa corporal se correlacionan entre sí en personas mayores de 60 años.
Método: Se realizó un estudio descriptivo correlacional en 1055 personas mayores de 60 años de diferentes países europeos pertenecientes al proyecto europeo IN COMMON SPORTS. Se realizó una valoración inicial de las variables antropométricas.
Resultados: Correlación significativa del IMC con el porcentaje de grasa corporal, CCi y CCa pero no con el ICC. El ICC presenta correlaciones proporcionales significativas con el CCi, e inversamente proporcionales con el CCa. El género masculino muestra una correlación significativa entre el ICC y IMC, pero no con el porcentaje de grasa corporal. El IMC promedio muestra una tendencia general alta para ambos géneros. Mujeres mayor porcentaje de grasa.
Conclusión: El IMC se correlaciona con ICC, CCa y CCi pero dependiendo del género. Los hombres mostraron correlaciones significativas entre IMC e ICC, pero en las mujeres no se encuentran correlaciones de estas medidas.
Relación del Special Wrestling Fitness Test con el rendimiento aeróbico
Authors: Herrera-Valenzuela Tomás , Cuadra Daniela , Valdés-Badilla Pablo , Cofre-Bolados Cristian , Pardo-Tamayo Carolina , Ojeda-Aravena Alex , Franchini Emerson 
Published: August 2021

Objetivo: Este estudio investigó la relación de variables fisiológicas aeróbicas durante el Special Wrestling Test Fitness con las variables fisiológicas medidas durante una prueba incremental en carrera.
Métodos: Ocho atletas cadetes y junior (hombres: 2; mujeres: 6) de lucha olímpica estilo libre realizaron el Special Wrestling Fitness Test determinando el número de derribos, el índice de la prueba y los valores picos de consumo de oxígeno, frecuencia cardíaca, cociente respiratorio y pulso de oxígeno. Adicionalmente los atletas realizaron una prueba incremental en tapiz rodante para determinar los valores picos de consumo de oxígeno, frecuencia cardíaca, cociente respiratorio y pulso de oxígeno. Para establecer la relación entre variables fue utilizada la prueba de Pearson (p < 0.05).
Resultados: Fue encontrada una correlación positiva entre la frecuencia cardíaca final durante el Special Wrestling Fitness Test y la frecuencia cardíaca pico durante la prueba incremental (r = 0.90; P = 0.002; IC95% = 0.54-0.98), entre la frecuencia cardíaca durante el Special Wrestling Fitness Test versus la frecuencia cardíaca pico durante la prueba incremental (r = 0.81; P = 0.002; IC95% = 0.53-0.98), y entre consumo de oxígeno pico durante el Special Wrestling Fitness Test versus el consumo de oxígeno pico durante la prueba incremental (r = 0.93; P = 0.001; IC95% = 0.67-0.99).
Conclusiones: Variables fisiológicas durante el Special Wrestling Fitness Test se relacionan con la respuesta fisiológica durante una prueba incremental medida de forma directa. Por lo tanto, los entrenadores podrían aplicar el Special Wrestling Fitness Test para monitorear las modificaciones en el rendimiento aeróbico producto del entrenamiento.
Análisis comparativo del sobrepeso y obesidad en adolescentes canarios y eslovenos a partir de la medida continua de la edad
Authors: Hernández Adelto , Cáceres Carlos Miguel , Borges-Hernández Pablo José , Marinšek Miha , Jurak Gregor 
Published: August 2021

Objetivo: comparar los niveles de sobrepeso y obesidad en 8416 adolescentes canarios y eslovenos de 14.60 ± 2.21 años, siendo el 49.96% mujeres.
Método: para describir el perfil de sobrepeso y obesidad se estimó, siguiendo las recomendaciones habituales, a través de la medida de la masa, altura y perímetro cintura, utilizando los criterios de la Fundación Orbegozo (2011), y calculando su media, desviación estándar, coeficiente de correlación por rangos, comparación de medias (U de Mann-Whitney) y de igualdad de proporciones (rho de Spearman). Hallando según el Índice de Masa Corporal, normopeso (79.83%), sobrepeso (10.89%) y obesidad (9.28%) estratificando la muestra por género y segmento de edad; y a partir de estas medidas, los valores límite Índice Cintura-Altura.
Resultados: no existen diferencias en cuanto a masa corporal entre canarios y eslovenos (p = 0.453), pero sí que se aprecian diferencias en altura (p = 0.012), cintura (p < 0.001), Índice de Masa Corporal (p = 0.002) e Índice Cintura-Altura (p < 0.001).
Conclusiones: existen diferencias en la estructura corporal entre ambas poblaciones. Por lo que parece evidente la necesidad de emplear ambas medidas para obtener un diagnóstico completo de la obesidad en la adolescencia.
Intermittent fasting in the prevention and treatment of cancer
Authors: Clifton Katherine K. , Ma Cynthia X. , Fontana Luigi , Peterson Lindsay L. 
Published: August 2021

AbstractChronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and clinical studies but may be difficult to sustain. As an alternative to CR, there has been growing interest in intermittent fasting (IF) in both the scientific and lay community as a result of promising study results, mainly in experimental animal models. According to a survey by the International Food Information Council Foundation, IF has become the most popular diet in the last year, and patients with cancer are seeking advice from oncologists about its beneficial effects for cancer prevention and treatment. However, as discussed in this review, results from IF studies in rodents are controversial and suggest potential detrimental effects in certain oncologic conditions. The effects of IF on human cancer incidence and prognosis remain unknown because of a lack of high‐quality randomized clinical trials. Preliminary studies suggest that prolonged fasting in some patients who have cancer is safe and potentially capable of decreasing chemotherapy‐related toxicity and tumor growth. However, because additional trials are needed to elucidate the risks and benefits of fasting for patients with cancer, the authors would not currently recommend patients undergoing active cancer treatment partake in IF outside the context of a clinical trial. IF may be considered in adults seeking cancer‐prevention benefits through means of weight management, but whether IF itself affects cancer‐related metabolic and molecular pathways remains unanswered.
A Hyper-Viscoelastic Continuum-Level Finite Element Model of the Spinal Cord Assessed for Transverse Indentation and Impact Loading
Authors: Rycman Aleksander , McLachlin Stewart , Cronin Duane S. 
Published: August 2021

Finite Element (FE) modelling of spinal cord response to impact can provide unique insights into the neural tissue response and injury risk potential. Yet, contemporary human body models (HBMs) used to examine injury risk and prevention across a wide range of impact scenarios often lack detailed integration of the spinal cord and surrounding tissues. The integration of a spinal cord in contemporary HBMs has been limited by the need for a continuum-level model owing to the relatively large element size required to be compatible with HBM, and the requirement for model development based on published material properties and validation using relevant non-linear material data. The goals of this study were to develop and assess non-linear material model parameters for the spinal cord parenchyma and pia mater, and incorporate these models into a continuum-level model of the spinal cord with a mesh size conducive to integration in HBM. First, hyper-viscoelastic material properties based on tissue-level mechanical test data for the spinal cord and hyperelastic material properties for the pia mater were determined. Secondly, the constitutive models were integrated in a spinal cord segment FE model validated against independent experimental data representing transverse compression of the spinal cord-pia mater complex (SCP) under quasi-static indentation and dynamic impact loading. The constitutive model parameters were fit to a quasi-linear viscoelastic model with an Ogden hyperelastic function, and then verified using single element test cases corresponding to the experimental strain rates for the spinal cord (0.32–77.22 s−1) and pia mater (0.05 s−1). Validation of the spinal cord model was then performed by re-creating, in an explicit FE code, two independent ex-vivo experimental setups: 1) transverse indentation of a porcine spinal cord-pia mater complex and 2) dynamic transverse impact of a bovine SCP. The indentation model accurately matched the experimental results up to 60% compression of the SCP, while the impact model predicted the loading phase and the maximum deformation (within 7%) of the SCP experimental data. This study quantified the important biomechanical contribution of the pia mater tissue during spinal cord deformation. The validated material models established in this study can be implemented in computational HBM.
Novel Bis-Thiazole Derivatives: Synthesis and Potential Cytotoxic Activity Through Apoptosis With Molecular Docking Approaches
Authors: Dawood Kamal M. , Raslan Mohamed A. , Abbas Ashraf A. , Mohamed Belal E. , Abdellattif Magda H. , Nafie Mohamed S. , Hassan Mohamed K. 
Published: August 2021

A series of bis-thiazoles 5a–g were synthesized from bis-thiosemicarbazone 3 with hydrazonoyl chlorides 4a–g. Reaction of 3 with two equivalents of α-halocarbonyl compounds 6–8, 10, and 12a–d afforded the corresponding bis-thiazolidines 9, 11, and 13a–d, respectively. Condensation of bis-thiazolidin-4-one 9 with different aromatic aldehydes furnished bis-thiazolidin-4-ones 14a–d. Compounds 5a–g, 9, and 13a,c,d were screened in vitro for their cytotoxic activities in a panel of cancer cell lines. Compounds 5a–c, 5f–g, and 9 exhibited remarkable cytotoxic activities, especially compound 5c with potent IC50 value 0.6 nM (against cervical cancer, Hela cell line) and compound 5f with high IC50 value 6 nM (against ovarian cancer, KF-28 cell line). Compound 5f–induced appreciated apoptotic cell death was measured as 82.76% associated with cell cycle arrest at the G1 phase. The apoptotic pathways activated in KF-28 cells treated with 5a, 5b, and 5f were further investigated. The upregulation of some pro-apoptotic genes, bax and puma, and the downregulation of some anti-apoptotic genes including the Bcl-2 gene were observed, indicating activation of the mitochondrial-dependent apoptosis. Together with the molecular docking studies of compounds 5a and 5b, our data revealed potential Pim-1 kinase inhibition through their high binding affinities indicated by inhibition of phosphorylated C-myc as a downstream target for Pim-1 kinase. Our study introduces a set of bis-thiazoles with potent anti-cancer activities, in vitro.
A Novel UHPLC-MS/MS Method for Measuring 8-iso-Prostaglandin F2α in Bronchoalveolar Lavage Fluid
Authors: Holder Cory , Adams Aaron , Allison Claire , Cote Olivia , Lippens Rachel , Blount Benjamin C , Wang Lanqing 
Published: August 2021

In August 2019, the Centers for Disease Control and Prevention (CDC) received the first reports of lung injuries that were eventually termed e-cigarette, or vaping, product use–associated lung injury (EVALI). As part of the investigation, CDC laboratories rapidly developed assays for analyzing substances in bronchoalveolar lavage (BAL) fluid collected from EVALI case patients. This report describes the development and validation of a high-throughput isotope dilution UHPLC-MS/MS method for measuring a major oxidative stress biomarker, 8-iso-prostaglandin F2α (8-isoprostane), in BAL fluid samples. The method showed good sensitivity, 17.6 pg/ml LOD, and requires only 50 μl of sample volume. The method had high throughput with an analytical run time of 11 min. The within-day and between-day coefficient of variation (CV) were below 2%. Accuracy, calculated from spiked recovery, at three spiking levels, ranged from 95.5–101.8%. This novel UHPLC-MS/MS method characterizes oxidative stress in lung epithelial tissue and thus helps to elucidate potential pathologic processes.
Anemia of Chronic Disease in Patients With Cardiovascular Disease
Authors: Lanser Lukas , Fuchs Dietmar , Scharnagl Hubert , Grammer Tanja , Kleber Marcus E. , März Winfried , Weiss Günter , Kurz Katharina 
Published: August 2021

Objective:Anemia is often found in patients with coronary artery disease (CAD) or acute coronary syndrome (ACS) and related to disease severity. Our study investigated the relationship between anemia, iron homeostasis and inflammation in CAD and examined their influence on the outcome of patients.Patients and Methods:Markers of immune activation (neopterin, interleukin [IL]-12, IL-6, high sensitive C-reactive protein (hsCRP), fibrinogen, serum amyloid A [SAA]) and iron metabolism (ferritin, transferrin saturation, hemoglobin) were determined in 2,082 patients (68.7 % men, median age 63 years) from the Ludwigshafen Risk and cardiovascular Health (LURIC) cohort. Patients were followed-up for a median of 9.81 years.Results:960 patients (46.1 %) presented with chronic CAD, 645 patients (31.0 %) had an ACS, and 477 patients (22.9 %) presented with no CAD in coronary angiography (CAG). Anemia (n= 357, 17.1 %) was associated with disease severity (reflected by more progressed stenosis in CAG, CCS, and NYHA classes, and a lower LV-EF), a higher cardio-cerebrovascular event rate and higher levels of inflammatory markers. Interestingly, anemia was only predictive for an adverse outcome in patients with elevated inflammatory markers. Accordingly, anemia of chronic disease (ACD) was associated with a higher cardio-cerebrovascular event-rate in the subsequent 2 years as compared to patients with other types of anemia or without anemia (14.3 vs. 6.1 vs. 4.0%,p&lt; 0.001).Conclusions:This study confirms that anemia and immune activation are strongly related to cardiovascular disease progression and an adverse outcome. Our data suggest that the association of anemia with disease severity and outcome might mainly be due to underlying inflammation.
Association of Post-operative Systolic Blood Pressure Variability With Mortality After Coronary Artery Bypass Grafting
Authors: Zhou Zhuoming , Chen Jiantao , Fu Guangguo , Zhuang Xiaodong , Hou Jian , Chen Sida , Huang Suiqing , Yue Yuan , Shang Liqun , Wang Keke , Lv Linhua , Liang Mengya , Wu Zhongkai 
Published: August 2021

Background: Blood pressure variability (BPV) has long been considered a risk factor for cardiovascular events. We aimed to investigate whether post-operative systolic BPV was associated with early and late all-cause mortality in patients undergoing coronary artery bypass grafting (CABG).Methods: Clinical variables and blood pressure records within the first 24 h in the post-operative intensive care unit stay from 4,509 patients operated on between 2001 and 2012 were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. BPV was measured as the coefficient of the variability of systolic blood pressure, and we compared patients in the highest quartile with patients in the other three quartiles.Results: After full adjustment, patients in the highest quartile of BPV were at a higher risk of intensive care unit mortality (OR = 2.02, 95% CI: 1.11–3.69), 30-day mortality (OR = 1.92, 95% CI: 1.22–3.02), and 90-day mortality (HR = 1.64, 95% CI: 1.19–2.27). For 2,892 patients with a 4-year follow-up, the association between a higher post-operative BPV and the risk of 4-year mortality was not significant (HR = 1.17, 95% CI: 0.96–1.42). The results were supported by the comparison of survival curves and remained generally consistent in the subgroup analyses and sensitivity analyses.Conclusions: Our findings demonstrated that in patients undergoing CABG, a higher post-operative BPV was associated with a higher risk of early mortality while the association was not significant for late mortality. Post-operative BPV can support doctors in identifying patients with potential hemodynamic instability and making timely clinical decisions.
Association Between C-Peptide Level and Subclinical Myocardial Injury
Authors: Chen Ziwei , He Jing , Ma Qiang , Xiao Mingbing 
Published: August 2021

BackgroundPrevious studies have confirmed an association between C-peptide levels with the risk of cardiometabolic diseases. However, whether circulating C-peptide was related to subclinical myocardial injury (SC-MI) remains unknown.MethodsA total of 3,752 participants without a history of cardiovascular diseases were included in our study from National Health and Nutrition Examination Survey III (NHANES III). Multivariable linear regression was performed to explore the correlation between C-peptide and cardiac injury score (CIIS). Multivariate logistic regression was used to examine the association between C-peptide quartile and SC-MI.ResultsCirculating C-peptide was significantly associated with CIIS (β:0.09, 95% confidence interval [CI]: 0.00–0.17; p = 0.041). Compared with the lowest quartile, the highest quartile of circulating C-peptide increased a 1.48-fold risk of SC-MI (Odds ratio = 1.66, 95% CI: 1.18–1.87; p = 0.001).ConclusionsThe level of C-peptide was independently associated with CIIS and SC-MI, which could serve as a new risk factor of SC-MI.
The Associations of Serum Osteocalcin and Cortisol Levels With the Psychological Performance in Primary Hyperparathyroidism Patients
Authors: Wang Shu-min , He Yang , Zhu Min-ting , Tao Bei , Zhao Hong-yan , Sun Li-hao , Liu Jian-min 
Published: August 2021

ObjectivesThe aim of this study was to investigate factors responsible for the psychological performance in primary hyperparathyroidism (PHPT) patients.MethodsA group of 38 PHPT patients receiving questionnaires, including Beck Depression Inventory (BDI), State–Trait Anxiety Inventory (STAI), and 36-Item Short Form Survey (SF-36), was evaluated. The relationships between scores of questionnaires and clinical biomarkers were examined. Collinearity and linear regression model were applied to examine variables determining the scores of the questionnaire. In 192 PHPT patients, bivariate and partial correlation were used to analyze the relationships between serum concentrations of parathyroid hormone (PTH), calcium, osteocalcin (OCN), and cortisol.ResultsAmong 38 patients receiving questionnaire tests, 50% (19/38) of the patients developed state anxiety, 60.5% (23/38) of the patients had the trait of developing anxiety. In addition, 18.4% (7/38) of the patients developed mild to severe depression. Serum cortisol at 8:00 was negatively and significantly correlated with social function (r = -0.389, p = 0.041) after controlling for age, sex, disease duration, serum PTH, calcium, phosphorus, and 25-hydroxyvitamin D [25(OH)D] concentration. OCN was significantly and negatively correlated with score of STAI-S (r = -0.426, p = 0.027). In the linear regression model for BDI score, variables with statistical significance were serum OCN (β = -0.422, p = 0.019) and cortisol at 0:00 (β = 0.371, p = 0.037). In 192 PHPT patients, the serum concentration of OCN (r = 0.373, p = 0.000) was positively correlated with PTH level. After controlling for age, sex, disease duration, serum 25(OH)D, phosphorus, and calcium concentration, the positive correlation between OCN and PTH was still statistically significant (r = 0.323, p = 0.000). The serum concentration of cortisol at 0:00 was significantly and positively correlated with serum calcium (r = 0.246, p = 0.001) in bivariate correlation analysis. After controlling for age, sex, disease duration, serum PTH, 25(OH)D, and phosphorus concentration, serum cortisol at 0:00 was still positively and significantly correlated with serum calcium (r = 0.245, p = 0.001).ConclusionSerum levels of OCN and cortisol, rather than PTH and calcium, are associated with the development of anxiety and depression symptoms in PHPT patients.
The Diagnostic Utility of the Basal Luteinizing Hormone Level and Single 60-Minute Post GnRH Agonist Stimulation Test for Idiopathic Central Precocious Puberty in Girls
Authors: Cao Ruixue , Liu Jinrong , Fu Pinguo , Zhou Yonghai , Li Zhe , Liu Peining 
Published: August 2021

ObjectiveThe present study aimed to assess the diagnostic utility of the Luteinizing hormone (LH) levels and single 60-minute post gonadotropin-releasing hormone (GnRH) agonist stimulation test for idiopathic central precocious puberty (CPP) in girls.MethodsData from 1,492 girls diagnosed with precocious puberty who underwent GnRH agonist stimulation testing between January 1, 2016, and October 8, 2020, were retrospectively reviewed. LH levels and LH/follicle-stimulating hormone (FSH) ratios were measured by immuno-chemiluminescence assay before and at several timepoints after GnRH analogue stimulation testing. Mann–Whitney U test, Spearman’s correlation, χ2 test, and receiver operating characteristic (ROC) analyses were performed to determine the diagnostic utility of these hormone levels.ResultsThe 1,492 subjects were split into two groups: an idiopathic CPP group (n = 518) and a non-CPP group (n = 974). Basal LH levels and LH/FSH ratios were significantly different between the two groups at 30, 60, 90, and 120 minutes after GnRH analogue stimulation testing. Spearman’s correlation analysis showed the strongest correlation between peak LH and LH levels at 60 minutes after GnRH agonist stimulation (r = 0.986, P &lt; 0.001). ROC curve analysis revealed that the 60-minute LH/FSH ratio yielded the highest consistency, with an area under the ROC curve (AUC) of 0.988 (95% confidence interval [CI], 0.982–0.993) and a cut-off point of 0.603 mIU/L (sensitivity 97.3%, specificity 93.0%). The cut-off points of basal LH and LH/FSH were 0.255 mIU/L (sensitivity 68.9%, specificity 86.0%) and 0.07 (sensitivity 73.2%, specificity 89.5%), respectively, with AUCs of 0.823 (95% CI, 0.799–0.847) and 0.843 (95% CI, 0.819–0.867), respectively.ConclusionsA basal LH value greater than 0.535 mIU/L can be used to diagnose CPP without a GnRH agonist stimulation test. A single 60-minute post-stimulus gonadotropin result of LH and LH/FSH can be used instead of a GnRH agonist stimulation test, or samples can be taken only at 0, 30, and 60 minutes after a GnRH agonist stimulation test. This reduces the number of blood draws required compared with the traditional stimulation test, while still achieving a high level of diagnostic accuracy.