bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of intrauterine hemodynamics on the C segment of the aortic arch in the fetus
Authors: Hubulava G. G. , Marchenko S. P. , Naumov A. B. , Strupeneva U. A. , Kulemin E. S. , Nevmerzhitskaya O. V. , Chupaeva O. Yu. , Seliverstova A. A. , Chernomordova A. V. , Andreev M. S. , Pilyugov N. G. , Kavardakova E. S. 
Published: September 2021

Objective. To assess the correlation between the hemodynamic characteristics of the left ventricle and geometric features of the aortic arch in the fetus.Methods. The study involved 31 fetuses from 29 to 34 weeks of gestation by echocardiography. The scientists assessed the morphogeometric characteristics of the left ventricle andaortic arch. They studied the following parameters: end-diastolic volume ofthe left ventricle (LVEDV), stroke volume of the leftventricle (LVSV), velocity-time integral of the flow through aortic valve (VTI AV), diameter of the aortic valve ring (AV), diameterof the aortic arch segment between brachiocephalic trunk and left carotid artery (dС). Results. The average gestational age was 31,9±1,4weeks (95% CI: 31,4–32,4 weeks). Average body weight 1899±377 g (95% CI: 1762–2038 g). LVEDV = 1,57±0,64 ml (95% CI: 1,3–1,8). LVSV = 1,3±0,45 ml (95% CI: 1,1–1,4 ml). AV 0,4±0,07 cm (95% CI: 0,39–0,44 cm). C segment of the aorticarc is 0,37±0,07 cm (95% CI: 0,035–0,040 cm). There was direct correlation between the variables used to calculate dC (Pearson correlation coefficient: LVEDV = 0,51; p=0,002; LVSV = 0,46; p=0,005; AV = 0,52, p=0,001). The diameter of the C segment of the aortic arch can be calculated using the following equations: dС= 0,76· LVSV +2,8 (95% CI LVSV 0,2–1,3 95% CI for constant2,1–3,6; Fisher’s criterion 7,6 р=0,01). dС= 0,59· LVEDV +2,8 (95% CI LVEDV 0,2–0,98; 95% CI for constant 2,2–3,5; Fisher’s criterion 10 р=0,004). dС= 0,59·AV+1,3 (95% CI AV 0,22–0,95; 95% CI for constant – 0,23–2,9; Fisher’s criterion 10,7;р=0,003).Conclusion. 1)hemodynamic characteristics of the left ventricle allow predicting the sizeof the aortic arch in fetuses from 29 to 34 weeks of gestation; 2)morphogeometric characteristics of the aortic arch are determined by the characteristics of the left ventricular stroke volume, end-diastolicvolume of the leftventricleand the sizeof the fibrous ring of the aortic valve.
Clinical and diagnostic significance of the intestinal fraction of fatty acid binding protein in children with protein-induced enteropathy
Authors: Prikhodchenko N. G. , Shumatova T. A. , Nee A. N. , Zernova E. S. 
Published: September 2021

Protein-induced enteropathyis a common manifestation of gastrointestinal food allergy in young children. Non-invasive diagnostic methods are especially relevant for the timely diagnosis and prevention of exacerbations.Objective. To evaluate serum, fecal and urinal levels of the intestinal fraction of fatty acids-binding proteins in children with protein-induced enteropathy and their clinical and diagnostic significance.Material and methods. The authors examined 29 children with protein-induced enteropathy aged from 1,5 to 12 months and 20 healthy children (control group). For differential diagnosis with congenital diseases of the gastrointestinal tract, all patients underwent esophagogastroduodenoscopy with morphological examination of biopsies. The Cow’s Milk-related Symptom Score (CoMMiS) was used to assess clinical symptoms. In all children, the intestinal fraction of the protein binding fatty acids (I-FABP) was determined in blood serum, urine, coprofiltrate byenzyme-linked immunosorbent assay.Results. The scientists found an increase in the protein level in the blood 125,20±23,79 pg/ml, in coprofiltrate 0,36±0,05 ng/ml, in urine 0,164±0,031 pg/ml compared with those in the control group (19,21±4,94pg/ml, 0,18±0,02 ng/ml and 0,039±4,62 pg/ ml, respectively; p<0,05). The authors found direct strong relationship between the degreeof morphological changes, clinical severity of gastrointestinal manifestations and the concentration of fatty acid binding protein in serum and urine, moderate relationship with the indicators in coprofiltrate (p<0,05).Conclusion. An increase in serum, fecal and urinal levels of I-FABP in children with protein-induced enteropathy confirms the clinical and diagnostic significance of this biomarker in all biological fluids. Its high sensitivity and specificity of determination in urine is promising for pediatric practice.
Retrospective analysis of the natural history of type 1 spinal muscular atrophy in children
Authors: Vlodavets D. V. , Ganina N. V. , Ilina E. S. , Kokorina A. A. , Kuzenkova L. M. , Sapego E. Yu. , Smirnov D. S. , Shevtsova Yu. A. , Saulina A. V. , Petrov A. N. , Zolkin N. A. , Linkova Yu. N. , Zinkina-Orikhan A. V. 
Published: September 2021

Objective. To analyze the natural course of type 1 spinal muscular atrophy in children with the onset of the disease up to 6 months in the Russian population.Material and methods. The retrospective multicenter study included data of 54 children with an established diagnosis of type 1 spinal muscular atrophy who did not receive therapy with nusinersen, risdiplam, branaplam, onasemogen abeparvovec-xioi, or other anti-sense oligonucleotides / selective SMN2 splicing modifiers or genetherapy drugs for SMN1 genetransduction. Basedon medical records, the scientists have collected all available information on the health status of children, the need for respiratory support and death or start of long-term mechanical ventilation.Results. The median time from birth to the onset of the combined event (death or initiation of long-term respiratory support), determined using the Kaplan-Meier method, was 365 [269; 409] days (12 months). The date of death was known in 22 out of 54 children. The median age of death was 301,5 [181; 375] days (9,9 months). The initiation date of long-term respiratory support was known in 15 of 54 patients, the median was 180 [91; 276] days (5,9 months). Both the start date of long-term respiratory support and the date of death were known in 5 of 54 children; whileit was found that the median time from the initiation of long-term respiratory support to death in these children was 361 [135; 619] day (11,87 months).In a subgroup of 32 children with available date of initiation of long-term respiratory support and / or the date of death, the median time from birth to the combined event was 245,5 [173; 331] days (8,07 months).Conclusion. In the course of a retrospective study, the authors obtained the information on the date of the onset of constant respiratory support and the date of death from the date of birth in the absence of pathogenetic treatment in children with type 1 spinal muscular atrophy. The data obtained in the Russian population are comparable with the published international data. This information can be useful for additional assessment of the health status of patients who received drugs affecting the level of SMN protein in the body, as well as reference data for the development of new approaches to therapy.
Correcting eating disorders in obese adolescents
Authors: Nikishina E. I. , Nikishina V. B. , Petrash E. A. 
Published: September 2021

The relevance of the study is conditioned by the need to study the way of eating as a method of correct in geating disorders in adolescents.Objective.To evaluate the correction potential of the nutrition method in adolescents with eating disorders by alimentary obesity type. Characteristic of children and research methods. At the first stage of the study the research sampling was based on the criteria for body mass index assessing in adolescents. The total size of the research sample was 69 adolescents aged13–16 years with alimentary obesity. The group was equalized by gender. At the second stage, the adolescents were surveyed to assess the rules for the use and content of food consumed, including energy value. At the third stage, all patients were divided into three research groups, two groups had a separate program for the correction of eating disorders, taking in to account the measured parameters.Results.The study confirmed the effectiveness of the nutritional disorders method by changing the eating rules and using object-mediated consumption of food (using cutlery – forks, knives, sticks). At the same time, the content, volume and frequency of food intake were preserved. The average weight loss with an indirect way of eating was up to 2 kg per week. In addition, they recorded a decrease in body mass index. The time of food intake significantly increased, which affects the control of the amount of food consumed, transferring eating actions from an involuntary level with a lack of fixation on taste sensations to an arbitrary one.Conclusion.The technique is recommended for use as part of the eating disorders correction, since it can be easily integrated into any methodological complex and has no contraindications.
Caesarean section in severe preeclampsia: features of early neonatal adaptation
Authors: Isaeva E. V. , Ryskeldieva V. T. 
Published: September 2021

Objective. To study the course of early neonatal adaptation depending on the anesthetic aid in abdominaldelivery of pregnant women with severe preeclampsia. Characteristic o fchildren and research methods. Thea uthorscarried outaprospective cohort study o f342 childrenborn from mothers with severepreeclampsia. The children were grouped according to their gestationalage. The author sanalyzed perinatallosse sand assessed general condition according to the Apgarscaleat the 1st and 5th minutes of life, aswell as the neurological status of newborns according to the NACS scale at the 15thminute of life and in 2 hours depending on the anesthesia method used during the caesareansection.Results. The authors found that the newborns from mothers with severe preeclampsia, starting from the 34th week of gestation, demonstrated a significantly more pronounced negative effect of total intravenous anesthesia on their somatic (birth in a state of hypoxia) and neurological status as compared with spinalanesthesia (р<0,05). ><0,05).Conclusion. The results are of practical value to neonatologists, as total intravenous anesthesia is expectedto causethe revealed violations of the adaptive ability of newborns and the doctor is able to provide adequate timely assistance to children.
Projetos em malha: do edifício à cidade
Authors: Macedo Adilson 
Published: September 2021

Edifícios e setores urbanos traçados em malha são um pretexto para repassar alguns conceitos que aguçaram a crítica ao Movimento Moderno nos anos 1960. O grupo de arquitetos conhecido por Team X, idealizou projetos de maneira que os prédios de um mesmo conjunto fossem interligados, divergindo da vertente Moderna de colocar edifícios únicos em espaços ajardinados. Da autoria de arquitetos relacionados ao Team X destaca-se o projeto vencedor do concurso internacional de anteprojetos para a Universidade Livre de Berlim que utilizou o princípio de malha ordenadora da área edificada e dos espaços livres. Desta referência tem início a trajetória deste autor, primeiro ligada às retículas para organizar o edifício como um bloco único, depois, graças a programas exigentes quanto a funcionalidade, veio a preocupação com os espaços gerados pelo movimento das pessoas e coisas, corredores para atravessar o prédio e corredores para distribuir a circulação no âmbito dos setores; conceitos que se estenderam depois para o estudo da forma e projeto da cidade. Mostram-se exemplos da possibilidade do uso das malhas por setores de um edifício, separados por corredores para pessoas e cargas, segundo o princípio de que o módulo para a organização dos espaços pode variar dentre os setores.
PALAVRAS-CHAVE: Malha urbana, projeto do edifício, projeto urbano
Development, Feasibility, Acceptability, and Utility of an Expressive Speech-Enabled Digital Health Agent to Deliver Online, Brief Motivational Interviewing for Alcohol Misuse: Descriptive Study
Authors: Boustani Maya , Lunn Stephanie , Visser Ubbo , Lisetti Christine 
Published: September 2021

Background
Digital health agents — embodied conversational agents designed specifically for health interventions — provide a promising alternative or supplement to behavioral health services by reducing barriers to access to care.

Objective
Our goals were to (1) develop an expressive, speech-enabled digital health agent operating in a 3-dimensional virtual environment to deliver a brief behavioral health intervention over the internet to reduce alcohol use and to (2) understand its acceptability, feasibility, and utility with its end users.

Methods
We developed an expressive, speech-enabled digital health agent with facial expressions and body gestures operating in a 3-dimensional virtual office and able to deliver a brief behavioral health intervention over the internet to reduce alcohol use. We then asked 51 alcohol users to report on the digital health agent acceptability, feasibility, and utility.

Results
The developed digital health agent uses speech recognition and a model of empathetic verbal and nonverbal behaviors to engage the user, and its performance enabled it to successfully deliver a brief behavioral health intervention over the internet to reduce alcohol use. Descriptive statistics indicated that participants had overwhelmingly positive experiences with the digital health agent, including engagement with the technology, acceptance, perceived utility, and intent to use the technology. Illustrative qualitative quotes provided further insight about the potential reach and impact of digital health agents in behavioral health care.

Conclusions
Web-delivered interventions delivered by expressive, speech-enabled digital health agents may provide an exciting complement or alternative to traditional one-on-one treatment. They may be especially helpful for hard-to-reach communities with behavioral workforce shortages.
Clinical Efficacy and Psychological Mechanisms of an App-Based Digital Therapeutic for Generalized Anxiety Disorder: Randomized Controlled Trial
Authors: Roy Alexandra , Hoge Elizabeth A , Abrante Pablo , Druker Susan , Liu Tao , Brewer Judson A 
Published: September 2021

Background
Current treatments for generalized anxiety disorder (GAD) often yield suboptimal outcomes, partly because of insufficient targeting of underlying psychological mechanisms (eg, avoidance reinforcement learning). Mindfulness training (MT) has shown efficacy for anxiety; yet, widespread adoption has been limited, partly because of the difficulty in scaling in-person–based delivery. Digital therapeutics are emerging as potentially viable treatments; however, very few have been empirically validated.

Objective
The aim of this study is to test the efficacy and mechanism of an app-delivered MT that was designed to target a potential mechanism of anxiety (reinforcement learning), based on which previous studies have shown concern regarding feedback and the perpetuation of anxiety through negative reinforcement.

Methods
Individuals with GAD were recruited using social media advertisements and randomized during an in-person visit to receive treatment as usual (n=33) or treatment as usual+app−delivered MT (Unwinding Anxiety; n=32). The latter was composed of 30 modules to be completed over a 2-month period. Associated changes in outcomes were assessed using self-report questionnaires 1 and 2 months after treatment initiation.

Results
We randomized 65 participants in this study, and a modified intent-to-treat approach was used for analysis. The median number of modules completed by the MT group was 25.5 (IQR 17) out of 30; 46% (13/28) of the participants completed the program. In addition, the MT group demonstrated a significant reduction in anxiety (GAD-7) compared with the control group at 2 months (67% vs 14%; median change in GAD-7: –8.5 [IQR 6.5] vs –1.0 [IQR 5.0]; P<.001; 95% CI 6-10). Increases in mindfulness at 1 month (nonreactivity subscale) mediated decreases in worry at 2 months (Penn State Worry Questionnaire; P=.02) and decreases in worry at 1 month mediated reductions in anxiety at 2 months (P=.03).

Conclusions
To our knowledge, this is the first report on the efficacy and mechanism of an app-delivered MT for GAD. These findings demonstrate the clinical efficacy of MT as a digital therapeutic for individuals with anxiety (number needed to treat=1.6). These results also link recent advances in our mechanistic understanding of anxiety with treatment development, showing that app-delivered MT targets key reinforcement learning pathways, resulting in tangible, clinically meaningful reductions in worry and anxiety. Evidence-based, mechanistically targeted digital therapeutics have the potential to improve health at a population level at a low cost.

Trial Registration
ClinicalTrials.gov NCT03683472; https://clinicaltrials.gov/ct2/show/NCT03683472
Population Pharmacokinetics Modeling of Levofloxacin In Rabbit By Intravenous Bolus Injection and Peroral Administration
Authors: Kharis Nugroho Akhmad , Pratiwi Puspa Dwi , Citrariana Shesanti , Lukitaningsih Endang , Hakim Lukman 
Published: September 2021

The population-based approach has been widely applied to describe the pharmacokinetic profile of many drugs. The aim of this current research was to study the implementation of the population-based pharmacokinetics of levofloxacin in rabbits administered by intravenous bolus injection and peroral delivery.
Modeling analyses were performed using Monolix, one of the alternative tools for the population-based approach. Monolix works based on the Stochastic Approximation Expectation-Maximization (SAEM) method. The analysis was performed based on the population model using one-compartmental and two-compartmental disposition models. The combination error model was used during the analyses. Modeling appropriateness was determined based on the goodness of fit analyses, i.e., 1) the individual fit, 2) the observed versus population prediction values; and 3) the observed versus individual prediction values
Plasma concentration profiles of levofloxacin by intravenous bolus injection and oral administration are better described by an appropriate model using a two-compartmental disposition model. All goodness of fit analyses demonstrates the power of the chosen model. However, the estimated disposition parameter values obtained based on the intravenous bolus injection and peroral administration are different for each subject. To confirm this phenomenon, we performed a simultaneous fitting of all intravenous bolus as well as peroral administration data. The goodness of fit analyses indicates an adequate fitting of all data.
Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
Authors: Yusuf Syarif Maulana , Indri Astuti Rika , Batubara Irmanida , Chavasiri Warinthorn 
Published: September 2021

Cellular aging is promoted by the deleterious effect of free radicals. This can be lowered by antioxidant treatments. Xylocarpus granatum and its compound, Xyloccensins K have been reported to have antioxidant activity but there have been no reports of antioxidant and anti-aging activities at the cellular level. Thus, the aim of this study to investigate the antioxidant and anti-aging properties of X. granatum-derived extract and Xyloccensins K at a cellular level in yeast Schizosaccharomyces pombe. Four vegetative and three generative parts of X. granatum organs including root, stem, leaf, twig, seed, flesh of fruit, and peel of fruit were extracted using 70% ethanol by the maceration method. Whereas, Xyloccensins K was obtained from seed of X. granatum. The samples tested, other than peel of fruit, prolonged cell longevity in lower concentration as compared to that without phytoextracts treatment. Also, our data indicate that all samples could promote oxidative stress tolerance phenotype, as yeast was capable of dealing with H2O2-induced oxidative stress treatment at 1, 2, and 3 mM H2O2 with the best phenotypes by the administration of twig extracts. Most of the phytoextracts showed an increase in mitochondrial activity, except that of seed extract. The result showed the administration of Xyloccensins K compound did not increase the expression of transcriptional factors of oxidative stress response gene cluster, sty1 and pap1. We suggest that the Xyloccensins K compound acts as direct Reactive Oxygen Species (ROS) scavenger. Thus further study in elucidating the phenomenon of longevity-induced X. granatum extract is required.
Anterior openbite malocclusion in adults:
Authors: Gu David , Leroux Brian , Finkleman Sam , Todoki Lauren , Greenlee Geoffrey , Allareddy Veerasathpurush , Jolley Cameron , Vermette Michael , Shin Kyungsup , Kau Chung How , de Jesus-Vinas Jaime , Dolce Calogero ,   The National Dental PBRN Collaborative Group, Huang Greg 
Published: September 2021

ABSTRACT

Objectives
To investigate stability and satisfaction in adult anterior open bite (AOB) patients at least 9 months post-treatment, as well as patient and practitioner factors that may be associated with stability and satisfaction.

Materials and Methods
Practitioners and their adult AOB patients were recruited through the National Dental Practice-Based Research Network. Data on patient and practitioner characteristics, treatment recommendations and factors were previously collected. Treatment stability was determined by assessing post-treatment intraoral photographs. Patient satisfaction was determined from post-treatment questionnaires. Treatment was categorized into aligners, fixed appliances, temporary anchorage devices, and orthognathic surgery. Extractions were also investigated. Retention type was categorized into vacuum-formed, Hawley-style, or bonded retainers, and regimens were classified as full-time or part-time wear.

Results
Retention data collected from 112 patients had a mean post-treatment time of 1.21 years. There were no statistically significant differences in stability between treatment groups. Depending on whether a qualitative index or a millimetric measure was employed, stability ranged from 65% to 89%. Extractions and less initial lower incisor proclination were associated with higher stability in patients treated with fixed appliances only. High satisfaction was reported by patients at retention. There were no clear differences in stability or satisfaction among retention types or regimens.

Conclusions
The stability of adult AOB orthodontic treatment was high, regardless of treatment or retainer modality. Satisfaction in adult AOB patients was high, regardless of retention type or regimen.