bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of metformin for treatment and prevention of antipsychotic-induced overweight and obesity in women: an open-label, randomized, prospective placebo-controlled study
Authors: Yunilaynen O. A. , Oleichik I. V. , Sizov S. V. , Baranov P. A. , Starostina E. G. 
Published: July 2021

Background:The prevalence of obesity and metabolic abnormalities is increased patients with mental disorders receiving psychopharmacotherapy, which significantly impairs their treatment adherence.Aims:To evaluate the efficacy and safety of metformin in prevention and treatment obesity and overweight in patients with mental disorders receiving antipsychotics.Materials and methods: This was an open-label, prospective, randomized, placebo-controlled study of female patients with mental disorders (age, 18 to 50). The patients were randomized into two groups in a 2:1 ratio: the treatment group received metformin and the control group received placebo. Metformin was administered at a starting dose of 500 mg daily, with subsequent up-titration every 2 weeks when necessary, up to 2000 mg daily. The treatment duration was 6 months.Results:Baseline BMI in the treatment group (N=62) was 27,3 [24,0; 30,4] kg/m2; it decreased to 26,0 [22,5; 30,5] kg/m2, p < 0.0001, Wilсoxon test) after 6 months of treatment. The patients receiving metformin decreased their body weight by 3 [-6; 0] kg, or -4,0 [-8; 0] %. In the placebo group (N=30), the baseline BMI was 27,5 [24,0; 32,0] kg/m2and increased to 28,2 [25,8; 34,0] kg/m2at 6 month (p=0.001, Wilсoxon test), or 3 [1; 6] kg. After 6 months of treatment, the difference in BMI between the metformin and placebo groups was significant (26,0 и 28,2 kg/m2, respectively, р=0,027, Mann-Withney test). Six (6) of 62 patients treated with metformin had side effects and were switched to an equivalent dose of prolonged release metformin, with reduction of side effects in 5 of them.Conclusions:The use of metformin in patients with mental disorders receiving antipsychotics allows for reduction or stabilization of body weight in 80% of cases, with ≥5% decrease of body weight in 44% of patients. It is recommended to start metformin at a dose of 500 mg daily with subsequent up-titration of up to 2000 mg if necessary.
Obesity and functional bowel disorders: are they linked?
Authors: Pogodina A. V. , Romanitsa A. I. , Rychkova L. V. 
Published: July 2021

Obesity and functional bowel disease (FBD) are affecting a large number of people worldwide. They have psychosocial consequences and associated with considerable healthcare resource use. The purpose of this review was a comprehensive study of the relationship between obesity and FBD, as well as mechanisms to explain this relationship. An analysis of the literature provides strong evidence of a link between obesity and diarrhea, but there is currently insufficient data to speak confidently about the link between obesity and irritable bowel syndrome. Most studies suggest that adult obesity is not associated or negatively associated with constipation. The association of obesity with diarrhea is most convincingly explained through diet, eating behavior, changes in the metabolism of bile acids, accelerated colonic transit, altered intestinal microbiota and associated inflammation and increased intestinal permeability. Medicines taken by patients, as well as non-alcoholic fatty liver disease, can play their own role.Planning and conducting studies, including longitudinal ones, based on valid diagnostic criteria and taking into account the widest possible range of confounders, will allow a deeper study of the problem of comorbidity of obesity and FBD. This will help optimize the treatment of these diseases.
Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series
Authors: Kovaleva E. V. , Eremkina A. K. , Mokrysheva N. G. 
Published: July 2021

Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcemia and hyperphosphatemia, due to absent or inappropriately low serum parathyroid hormone (PTH) levels. The chronic postoperative hypoparathyroidism accounts approximately 75% of patients; the genetic, autoimmune or idiopathic forms are significantly less common. Today, chronic hypoparathyroidism remains the last major endocrine deficiency, for which hormonal replacement therapy has not found widespread use. Achieving the target levels of phosphorus-calcium metabolism is an important factor of the disease control, required for the prevention of short- and long-term complications. The standard therapy with active metabolites/analogues of vitamin D (­alfacalcidol, calcitriol) and calcium supplements does not always allow to achieve the target treatment goals. Despite high doses of calcium and active vitamin D, some patients suffer from unstable calcium levels and associated symptoms.The measurement of serum calcium and phosphorus in the early morning hours remains the main laboratory tests for such patients, but in sometimes this diagnostic approach does not really reflect the true picture.The presented clinical cases describe the changes of both hyper- and hypocalcemia within one day in patients with chronic postsurgical hypoparathyroidism managed by standard therapy.
Familial case of hypogonadotropic hypogonadism as the CHARGE syndrome manifestation
Authors: Khabibullina D. A. , Kalinchenko N. Yu. , Egorova S. V. , Vasilyev E. V. , Petrov V. M. , Tiulpakov A. N. 
Published: July 2021

CHARGE syndrome is a rare autosomal dominant disease caused by CHD7 gene mutations. Individuals with CHARGE display a wide spectrum of clinical features. It might be presented only as a delay puberty, which does not require any hormone replacement therapy to severe CHARGE phenotype, requiring a multidisciplinary therapeutic approach. Wild spectrum of clinical presentation can be seen even among the patients with identical mutation. Diagnosis might be suspected by a combination of major and minor clinical criteria of this disorder, but molecular genetic analysis is mandatory for final verification. Accurate diagnosis is essential to informing patients about all possible clinical features, reproductive status and choosing the correct treatment approach. The most common endocrine abnormality in patients with CHARGE syndrome is the disturbance in gonadotropins function ranged from delay puberty to persistent hypogonadotropic hypogonadism with different olfactory phenotypes, resulted by specific role of CHD7 in GnRH neuronal embryogenesis.We describe a familial case of CHARGE syndrome with significant intrafamilial clinical heterogeneity due to CHD7 gene mutation.
A machine learning-driven stochastic simulation of underground sulfide distribution with multiple constraints
Authors: Ji Qiuyan , Han Feilong , Qian Wei , Guo Qing , Wan Shulin 
Published: July 2021

Abstract
The increase of sulfide (S2−) during the water flooding process has been regarded as an essential and potential risk for oilfield development and safety. Kriging and stochastic simulations are common methods for assessing the element distribution. However, these traditional simulation methods are not able to predict the continuous changes of underground S2− distribution in the time domain by limited known information directly. This study is a kind of attempt to combine stochastic simulation and the modified probabilistic neural network (modified PNN) for simulating short-term changes of S2− concentration. The proposed modified PNN constructs the connection between multiple indirect datasets and S2− concentration at sampling points. These connections, which are treated as indirect data in the stochastic simulation processes, is able to provide extra supports for changing the probability density function (PDF) and enhancing the stability of the simulation. In addition, the simulation process can be controlled by multiple constraints due to which the simulating target has been changed into the increment distribution of S2−. The actual data test provides S2− distributions in an oil field with good continuity and accuracy, which demonstrate the outstanding capability of this novel method.
Does Health Insurance Affect the Completeness of Antenatal Care?
Authors: Wulandari Ratna Dwi , Laksono Agung Dwi 
Published: July 2021

The antenatal treatment has been ineffective in reducing maternal mortality. Therefore, this study aimed to examine health insurance effect on Indonesia's antenatal care quality. The 2017 Indonesian Demographic and Health Survey data were processed. Moreover, a sample size of 15,351 participants was selected using the analysis unit of study for women aged 15 to 49. In the final stage, Binary Logistic Regression was used, while other variables examined besides antenatal treatment included health insurance, residence, age, marital, education, parity, and wealth. Based on the complete category of antenatal care visits, women that did antenatal care visits were ≥ four, occupied by both types of health insurance ownership. The multivariable analysis indicated that health insurance ownership affects antenatal care completeness as insured women were 1.394 times higher than uninsured women (OR= 1.394; 95% CI= 1.257-1.546). Result showed other determinant variables, namely age, education, parity, and wealth were also found. In conclusion, health insurance gives Indonesian women a better possibility of receiving complete antenatal care.
Knowledge of Tuberculosis among Tuberculosis Patients Attending Federal Medical Centre, Owo, Ondo State, Nigeria
Authors: Akorede Seun Nurudeen , Ajayi Ayodotun Edward , Tawose Peter Oluwatimilehin 
Published: July 2021

Globally, tuberculosis (TB) constitutes a significant public health emergency. Despite the downward trend in TB incidence and prevalence, every continent still reports new cases, especially Africa and south-east Asia (WHO, 2012). This study aimed to investigate the signs, symptoms, transmission mode, and knowledge of tuberculosis (TB) among tuberculosis patients attending Federal Medical Centre, Owo, Ondo State Nigeria. A descriptive survey design was adopted, while sample population comprised of all the aforementioned tuberculosis patients. About 151 persons were selected using Multistage sampling procedure. A closed-ended questionnaire collection was used for data collection and the instrument was validated by experts with ascertained reliability. The data were then subjected to statistical analysis of Cronbach's alpha, and a correlation coefficient of 0.76 was obtained. Conclusively, the patients have knowledge of TB signs and symptoms as well as transmission mode. Therefore, this knowledge is recommended to be sustained among the patients.
Multistage sampling procedure was used to select one hundred and fifty-one (151) a researcherâ€™s designed closed-ended questionnaire was used for data collection. The instrument was validated by experts with reliability ascertained. The data obtained were subjected to statistical analysis of Cronbach alpha and a correlation coefficient of 0.76 was obtained. The findings reveals that: Tuberculosis patients have knowledge of signs and symptoms of TB, Tuberculosis patients have knowledge of mode of transmission of TB
Therefore, the study concluded that tuberculosis patients have knowledge of mode of transmission, signs and symptoms of TB. Therefore, it is recommended that the knowledge of mode of transmission and symptoms of TB should be sustained among the patients.
Adolescent Use of and Susceptibility to Heated Tobacco Products
Authors: Li Shuwen , Braden Katherine , Zhuang Yue-Lin , Zhu Shu-Hong 
Published: July 2021

BACKGROUND AND OBJECTIVES
A leading brand of heated tobacco products (HTPs), IQOS, was authorized to be sold in the United States in 2019. Researchers have examined the awareness and use of HTPs among US adults. In this study, we examined high school students’ awareness, use, and susceptibility pertaining to HTPs.

METHODS
A large, cross-sectional population survey of randomly sampled 10th- and 12th-graders in California (N = 150 516) was conducted online during school hours from September 2019 to March 2020.

RESULTS
Overall, 8.9% (95% confidence interval [CI], 8.7%–9.1%) of California high school students had heard of HTPs. Approximately 0.67% (95% CI, 0.61%–0.73%) had ever tried HTPs, and 0.20% (95% CI, 0.17%–0.23%) were current users (ie, ∼30% of ever users continued to use HTPs at the time of survey). Among those who never tried HTPs, 18.3% (95% CI, 17.9%–18.8%) were susceptible to future use. The susceptibility to HTP use was greater among users of cigarettes or e-cigarettes than among nonusers.

CONCLUSIONS
The awareness of HTPs among adolescents was remarkable given the low availability of products at the time of survey. Only a small percentage of adolescents experimented with HTPs. However, almost a third of those who had experimented with HTPs continued to use them. This high ratio and the fact that almost 1 out of 5 never users were susceptible to future HTP use should put the public health community on high alert as more HTP products are coming into the market, with promotion of these products likely to increase.
Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment
Authors: GÜRBÜZ Mustafa Can , KIRTAK Necmettin , TAŞ ÖZYURTSEVEN Betül 
Published: July 2021

Purpose: The aim of this study is to compare the effects of acyclovir and penciclovir creams in the treatment of recurrent herpes labialis.
Materials and Methods: Seventy patients with pre-diagnosed recurrent herpes labialis lesions were enrolled in this study. Diagnosis was confirmed with HSV-1 IgM antibody test. Patients were separated under 2 treatment groups as acyclovir and penciclovir cream. Both agents were applied until complete healing of the lesions was seen. Burning, itching and bleeding scores; time of erythema, vesicles, ulceration, crusting and crust loss of the lesions were recorded. Pain values of the patients were recorded using a visual analog scale (VAS) and DASS-21 scale was used to measure emotional state related to depression, anxiety and stress.
Results: Pain level in the acyclovir group was significantly lower than the penciclovir group in the 3rd day, though with no difference in the following days. DASS-21 scores revealed signs of depression on 62.8% of the patients, anxiety on 34.2% of the patients, and stress on 41.4% of the patients in moderate or higher levels. While the pain level was higher in patients with high anxiety severity, it was observed that the pain level was low in patients with high stress intensity.
Conclusion: Although it is not possible to cure recurrent herpes labialis completely, any methods and drugs that shorten the healing time of the lesion and reduce pain and discomfort gains importance. Our study showed that acyclovir is superior in reducing pain.
Pengembangan Sistem Inventory Praktikum Pemesinan Berbasis Web di Laboratorium Pemesinan Jurusan Teknik Mesin Fakultas Teknik Universitas Negeri Malang
Authors: Wijanarko Febri Eko 
Published: July 2021

Abstract: This research aims to create a web-based machining practicum inventory system program that can assist laboratory assistants and students in the process of borrowing practicum equipment, as well as facilitate laboratory assistants in monitoring and registering all equipment contained in the machining laboratory. In this study, the validation of the program has been developed by involving two experts, namely material experts and media experts. Validation have been use to determine the feasibility of the program that has been developed before it will be tested on students majoring in mechanical engineering. The results of trials product by respondents, there are two aspects which are assessed namely, material aspects and media aspects. The score obtained from the material aspect was 96.25% and 96.125% was obtained from the media aspect, so the total score obtained from trials to students majoring in mechanical engineering was 96.18%. Key words: inventory system, machining practicum, web
Analisis Faktor Orang Tua Menyekolahkan Anak pada Sekolah Dasar Berbasis Islam di Kota Malang
Authors: Khasanah Nova Nur , Arifin Imron , Nurabadi Ahmad 
Published: July 2021

Abstract: This study intends to explore the factors behind the choice of parents to send their children to Islamic based elementary schools in Malang city. The sample consisted of 162 class I parents using cluster/area sampling and proportional sampling. The data collection tool is a closed questionnaire. While data analysis uses SPSS 24.00 for windows. The results of the study obtained factors that influence the choice of parents to send their children to Islamic based elementary schools in Malang, namely religious factors, character education, school quality, potential development, and service.
Abstrak: Penelitian ini bermaksud untuk menggali faktor yang melatarbelakangi pilihan orangtua menyekolahkan anak pada SD berbasis Islam di Kota Malang. Sampel terdiri atas 162 orangtua kelas I dengan menggunakan cluster/area sampling dan proportional sampling. Alat pengumpul data adalah angket tertutup. Sedangkan analisis data menggunakan SPSS 24.00 for windows. Hasil penelitian diperoleh faktor yang mempengaruhi pilihan orangtua menyekolahkan anak pada SD berbasis Islam di Kota Malang yaitu faktor religi, pendidikan karakter, mutu sekolah, pengembangan potensi, dan pelayanan.
<b>Sistema Cone Morse e utilização de pilares com plataforma switching</b>
Authors: Varise César Gilioli , Abi-Rached Filipe Oliveira , Messias Aion Mangino , Das Neves Flávio Domingues , Segalla José Cláudio Martins , Reis José Maurício Dos Santos Nunes 
Published: July 2021

Os implantes cone morse associados a pilares com plataforma switching têm proporcionado resultados promissores com relação à estabilidade dos
tecidos peri-implantares. Isso se deve ao perfil cônico do componente protético, à íntima adaptação na interface implante/pilar e ao menor acúmulo de biofilme bacteriano. Para isso, deve-se levar em consideração o posicionamento infraósseo do implante. Essa configuração implante/pilar possui resistência
à fratura superior em relação aos sistemas convencionais e, além disso, devido à manutenção da crista óssea e da diversidade de pilares e componentes protéticos, possibilita reabilitações orais estéticas e biocompatíveis.

DOI: 10.18363/rbo.v72i1/2.578
Monitoring Polymer Flooding Performance Using Inflow Tracer Technology in Horizontal Injection and Production Wells
Authors: Janczak A. , Oftedal G. , Nikjoo E. , Hoy M. , Puls C. , Florian T. , Kornberger M. , Knauhs P. , Davidescu B. , Huseby O. , Clemens T. 
Published: July 2021

Summary
Horizontal wells are frequently used to increase injectivity and for cost-efficient production of mobilized oil in polymer-augmented waterfloods. Usually, only fluid and polymer production data at the wellhead of the production well are available. We used inflow tracer technology to determine changes in hydrocarbon influx owing to polymer injection and to determine the connection from various zones of the horizontal injector to the horizontal producer.
Inflow tracer technology was introduced in horizontal polymer injection and production wells. In the production wells, tracers are released when they are contacted by water and oil. Oil and water tracer systems were used in the horizontal production wells. The changes in the observed tracer concentration were used to quantify changes in influx from various sections of the horizontal producers owing to polymer injection. The inflow tracer technology applied in the horizontal injection wells demonstrates connectivity between different sections of the injection wells and two surrounding vertical and horizontal production wells and opens the usage of this technology for interwell water tracer applications.
Inflow tracer technology enables one to elucidate the inflow from various sections of the horizontal wells and the changes thereof, even quantifying changes in influx of various fluids (oil and water). The information shows which sections are contributing and the substantial changes in the influx of oil from the various zones due to polymer solution injection. The overall incremental oil could be allocated to the various horizontal well sections based on the tracer results. Even zones that almost exclusively produced water before polymer injection showed a significant increase in oil influx. The inflow tracer technology installed in the injection well allowed us to analyze the connectivity of the injector to producer not only globally but spatially along the horizontal well. These data are used for reservoir characterization, to condition numerical models, and for reservoir management.
Conventional interwell tracer technology allows one to determine the connectivity and connected volumes of horizontal well polymer field developments. However, it reveals neither information about influx of the sections nor the connectivity of various sections of the horizontal wells. Inflow tracer technology closes this gap; it allows one to quantify changes in influx of the fluids. Furthermore, the newly developed installed injection well tracer technology gives spatial information about the connectivity of the horizontal well sections.
Smooth approximations by continuous choice-functions
Authors: Prunescu Mihai 
Published: July 2021

Abstract
We explore the existence of rational-valued approximation processes by continuous functions of two variables, such that the output continuously depends of the imposed error-bound. To this sake we prove that the theory of densely ordered sets with generic predicates is ℵ0- categorical. A model of the theory and a particular continuous choice-function are constructed. This function transfers to all other models by the respective isomorphisms. If some common-sense conditions are fulfilled, the processes are computable. As a byproduct, other functions with surprising properties can be constructed.
Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation
Authors: Hua Yinggang , Li Long , Cai Liangliang , Liu Guoyan 
Published: July 2021

Abstract

P2RY1 receptor is known to cause cancer by activating the ERK signal pathway, its DNA methylation status or even the corresponding regulatory mechanism remains unknown. In this study, DNA methylation chip was used to profile the genome-wide DNA methylation level in gastric cancer tissues. Proliferation and apoptosis of the SGC7901 gastric cancer cell line were determined after treatment with a selective P2RY1 receptor agonist, MRS2365. The promoter region of P2RY1 was found to be highly methylated with 4 hypermethylated sites (|Δβ value| >0.2) in diffuse gastric cancer and then were validated by bioinformatic analysis in TCGA database. Analysis of MRS2365-treated cells by annexin-V/PI staining and Caspase-3 activity assays indicated the induction of apoptosis in SGC7901 cells. P2RY1 receptor activation in human SGC7901 gastric cancer cells via the MRS2365 agonist induced apoptosis and reduced cell growth. High DNA methylation in the promoter region of P2RY1 may have contributed to the reduced expression of P2RY1’s mRNA, which is likely responsible for the “aggressive” nature of the diffuse type gastric cancer.