bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of interobserver reliability in localization of hard and soft tissue landmarks and three-dimensional measurements of the upper airway based on these landmarks using CBCT images
Authors: Daya  K Jangam , Kajol  M Talreja , Vikram Garcha , Abhijeet  V Patil , Sunaina  M Swatantramath , Pranali B Bahadure 
Published: July 2021

: To assess reliability in localization of hard and soft tissue landmarks of the upper airway and three-dimensional measurements of the upper airway based on these landmarks using CBCT images. : 22 full field of view (FOV) CBCT scan volumes were selected randomly and retrospectively made at the CBCT unit of Department of Oral Medicine and Radiology. Six anatomic landmarks that are relevant for upper airway analysiswere located and subsequently three-dimensional measurements (volume, minimum cross-sectional area (CSA), location of the CSA, anteroposterior and lateral dimensions of the CSA) in all planes (coronal, sagittal, axial) were performed based on these land marks by two observers, using Romexis software (4.2.0 R 10/13/15). : Correlation analysis by Cronbach’s Alpha.: Interobserver reliability of the landmark localization was excellent (Internal consistency 0.97-0.99) and for the three-dimensional upper airway measurements were good (Internal consistency 0.62-0.99).: The interobserver reliability of anatomical landmarks localization and three-dimensional measurements of the upper airway are good to excellent using Romexis software. Therefore, this methodology can be recommended for the upper airway analysis using CBCT images.
Women’s Reports of Barriers to and Facilitators of Oral Medication Adherence During Ovarian Stimulation: A Mixed Methods Pilot Study
Authors: E. Mahoney Diane , L. Russell Cynthia 
Published: July 2021

Background: Adherence to lifestyle modification recommendations remains problematic for women undergoing fertility treatment, raising concerns about the extent to which women adhere to prescribed medication regimens. Limited data have shown suboptimal oral medication adherence rates of 19% to 74%. The objective of this study was to explore what women perceive as barriers to and facilitators of oral medication adherence during fertility treatment cycles.
Methods: An exploratory mixed methods pilot study was conducted among a sample of 30 women who were actively taking one to two cycles of letrozole or clomiphene citrate for ovarian stimulation in conjunction with intrauterine insemination cycles. Medication adherence barriers were measured using a 20-item survey. Medication adherence facilitators and personal experiences with fertility treatment were assessed with structured interviews. Medication adherence was assessed with electronic event monitoring.
Results: The overall medication adherence median was 0.97 with a range of 0.75 to 1.00, and nine women (50%) demonstrated perfect adherence. The most commonly reported barriers were recently feeling sad, down, or blue (53%), and taking medication more than once per day (40%). Women with higher barrier scores had significantly lower medication adherence scores (p=0.02) compared to women with lower total barrier scores. Facilitators included using physical aides as reminders (60%) and establishing a daily routine (50%). No significant correlation was found between medication adherence scores and facilitators.
Conclusion: The dynamic interplay between perceived barriers and facilitators and women’s medication-taking patterns could influence whether or not medication regimens are followed correctly.
Musyawarah dan Mufakat Sebagai Solusi Pemanfaatan Tanah Fasilitas Umum Masyarakat
Authors: Eskanugraha Andika Putra 
Published: July 2021

Utilization of land for public facilities is the ideals of the constitution as stated that "to be used for the greatest prosperity of the people" and "land to function socially" based on Law No. 5/1960 concerning Basic Agrarian Regulations. The use of land for the public facilities does not give priority rights to a party or individual. Collective use within the community must be addressed wisely and proportionally in its use. A public road that is regarded as a public facility, no one can claim to be entitled to a road because it borders or is close to the land or occupancy.
With the closed access to the use and benefitting of roads as the public facilities, it is difficult to determine the violation of the law committed. There is a Provincial Regulation which regulates the prohibition of parking on the roads, but this prohibition is not well-regulated in other regions with its legal products. Disregarding in the community to the road users as public facilities, can become a social problem and must be resolved with a consensus reflecting the Pancasila as the life point of view. Deliberation and consensus is a solution to solving problems by involving Village Traditional Institutions or similar names based on regionalism. Deliberation and consensus as a solution to the use of land for public facilities, can produce decisions in village deliberations. The Village Customary Institution as a partner to the Village Government can propose the joint use of community public facilities to be regulated in a Village Regulation.
Normative legal research is the method used in this study. There is no violation of legal rules in the unwise use of public facilities, making this community problem must be resolved by the community itself by prioritizing the value of the Pancasila and after that it can be elaborated in the simplest rules in the Village Regulation.
UJI AKTIVITAS ANTIBAKTERI DAN FITOKIMIA KULIT BAWANG MERAH (Allium cepa L.) HASIL EKSTRAKSI METODE Microwave Assisted Extraction (MAE)
Authors: Sulistiyono Fitria Dewi , Sofihidayati Trirakhma , Lohitasari Bina 
Published: July 2021

Ekstrak kulit bawang merah mengandung flavonoid, polifenol, saponin, terpenoid dan alkaloid. Metode ekstraksi modern dengan memanfaatkan radiasi gelombang mikro yang disebut dengan MAE (Microwave Assisted Extraction) belum banyak dilakukan. Metode MAE terbukti lebih efektif karena pemanasan pelarut secara cepat dan efisien dibandingkan metode ekstraksi secara konvensional. Tujuan penelitan ini adalah mengetahui senyawa fitokimia dan aktivitas ekstrak kulit bawang merah dengan metode MAE pada Staphylococcus aureus. Deteksi senyawa fitokimia dilakukan dengan metode kualitatif, yaitu ada tidaknya senyawa flavonoid, saponin, alkaloid dan tanin. Aktivitas ekstrak kulit bawang merah terhadap S.aureus dilakukan dengan metode kertas cakram dengan melihat zona bening/hambat yang dihasilkan. Konsentrasi ekstrak yang digunakan adalah 5, 10, 15, 20 dan 25% (b/v). Hasil penelitian menunjukkan bahwa ektrak kulit bawang merah mempunyai senyawa flavonoid, saponin dan tanin. Ekstrak kulit bawang merah dapat menghambat pertumbuhan S.aureus ditunjukkan dengan adanya zona bening dari kosentrasi 5, 10, 15, 20 dan 25% (b/v) adalah 14; 15,5; 16; 19; 19,5 mm. Hasil tersebut menunjukan bahwa MAE lebih efektif daripada metode konvensional (maserasi) dalam menghambat S. aureus. Berdasarkan hasil aktivitas antibakteri, ekstrak kulit bawang merah dapat dimanfaatkan dalam dunia industri sebagai salah satu komponen produk pencegahan infeksi bakteri.

Onion skin extract containing flavonoid , catakin , saponin , terpenoid and alkaloid . Microwave Assisted Extraction (MAE) is modern method with microwave radiation. MAE have proven more effective because a solvent warming quickly and more efficient compared other methode (maseration). This study aims to explore the phytochemical activity presenced in onion skin extract. that was obtained by the Microwave Assited Extraction (MAE) method and to evaluate the antibacterial activity against Staphilococcus aureus. The phytochemical screening of onion skin extracted by using MAE revealed the presence of alkaloids, saponins, tannins and flavonoids. The antibacterial activity of onion skin extract was carried out against S. aureus by measuring the diameter of bacterial growth inhibition zones through the diffusion method. The results of qualitative phytochemical screening tests on onion skin extract shows that the positive sample contains alkaloids, saponins, tannins and flavonoids. Range of onion skin extract concentration used in this research were 5, 10, 15, 20, and 25% w/v. The inhibition zone of extract at concentration 5, 10, 15, 20, and 25% w/v were 14.00; 15.50; 16.00; 19.00; and 19.50 mm respectively. Base on antibacterial result, onion skin extract can be used as one ingredient in the manufacture of antibacterial products.
Prinsip-prinsip taman ramah anak berdasarkan sudut pandang pengguna
Authors: Maria Catalina Rosari , Pandelaki Edward , Suprapti Atiek 
Published: July 2021

<p>Penyediaan taman yang ramah anak sebagai sarana anak beraktivitas dan berinteraksi dengan lingkungan merupakan salah satu indikator keberhasilan Kota Layak Anak (KLA). Penelitian ini dilakukan di Taman Citra Satwa yang merupakan salah satu taman terluas di Kota Semarang dengan berbagai fasilitas permainan dan olahraga. Sebagai taman yang baru beroperasi, taman ini telah banyak diminati oleh anak dan remaja dan memiliki potensi untuk dimaksimalkan sebagai taman ramah anak. Beberapa tahun terakhir, penelitian mengenai taman ramah anak membahas apa saja prinsip dalam taman ramah anak dan evaluasi penerapan prinsip tersebut pada beberapa taman di Indonesia. Namun belum ada penelitian tentang pendapat pengguna taman terhadap prinsip-prinsip tersebut. Penelitian ini bertujuan untuk menemukan pendapat pengguna terhadap prinsip yang dianggap paling mutlak dan prinsip mana yang masih dapat dikompromikan dalam taman ramah anak. Demi mencapai tujuan tersebut, penelitian ini menggunakan metode kualitatif rasionalisitik dalam menggali dan menganalisa pendapat pengguna terhadap prinsip-prinsip taman ramah anak yang sebelumnya telah dirumuskan berdasarkan teori dan temuan dari penelitian sebelumnya. Hasil temuan penelitian ini menunjukkan bahwa menurut pengguna taman, prinsip yang terpenting adalah kesehatan. Prinsip yang dianggap penting selanjutnya adalah prinsip daya tarik taman, keamanan dan keselamatan, kenyamanan, kebutuhan sosial, pembelajaran dan terkahir adalah prinsip kemudahan akses pada taman.</p>
Prevalence of Musculoskeletal Disorders in Patients with Coronary Artery Disease
Authors: Bazdyrev E. D. , Terentyeva N. A. , Krivoshapova K. E. , Masenko V. L. , Wegner E. A. , Kokov А. N. , Pomeshkina S. A. , Barbarash O. L. 
Published: July 2021

Aim. To study the prevalence of musculoskeletal disorders in patients with stable coronary artery disease (CAD).Material and methods. Patients with stable CAD (n=387) were included in the study. The subjects were admitted to the hospital for planned myocardial revascularization (ages of 50-82). The median age was 65 [59;69] years. Most of the sample consisted of males - 283 (73.1%). 323 (83.5%) patients had arterial hypertension (AH), 57.1% - history of myocardial infarction, and a quarter of the patients had type 2 diabetes mellitus (DM). The study of musculoskeletal system included the identification of sarcopenia in accordance with The European Working Group on Sarcopenia in Older People (EWGSOP, 2019); verification of osteopenia/osteoporosis according to the WHO criteria (2008); diagnosing osteosarcopenia in case of sarcopenia and osteopenia/osteoporosis coexistence.Results. At the initial screening of sarcopenia in accordance with EWGSOP, clinical signs (according to the Strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire) were detected in 41.3% of cases, but further examination (dynamometry, quantitative assessment of skeletal muscle) confirmed this diagnosis only in 19.9% of patients with CAD. Among the examined patients with CAD a low T-score according to DEXA was found in 53 (13.7%) of cases, and osteopenia was diagnosed 10 times more often than osteoporosis (90.6% vs. 9.4%). Furthermore, due to combination of low bone density (osteopenia/osteoporosis) and reduced muscle mass and strength (sarcopenia), osteosarcopenia was verified in one patient. Thus, the study revealed the prevalence of particular types of musculoskeletal disorders in 105 (27.1%) patients with stable CAD. The most common type of musculoskeletal disorder was sarcopenia - 52 cases (13.4%); osteopenia/osteoporosis was detected in 28 patients (7.2%), osteosarcopenia in 25 (6.5%). The most pronounced clinical manifestation of sarcopenia and osteopenia/osteoporosis, reflected by a higher score on the SARC-F questionnaire, low handgrip strength, small area of muscle tissue, low musculoskeletal index, as well as low values of bone mineral density, were observed in patients with osteosarcopenia. Patients with osteopenia/osteoporosis did not differ significantly from patients without musculoskeletal conditions in most parameters, with the exception of the T-score, the average SARC-F score, and muscle strength in men. The conducted correlation analysis revealed not only the relationship between the parameters of musculoskeletal function, but also their association with age, duration of AH, CAD, and type 2 DM.Conclusion. Several types of musculoskeletal disorders were found in a third of patients with CAD. Sarcopenia was revealed to be the most frequent type of musculoskeletal disorder.
Assesment of Markers of Endothelial Dysfunction and Myocardial Stress in Patients with Hypertrophic Cardyomyopathy
Authors: Bogatyreva F. M. , Kaplunova V. Yu. , Kozhevnikova M. V. , Shakaryants G. A. , Yatsenko D. A. , Emelianov А. V. , Lishuta A. S. , Khabarova N. V. , Privalova E. V. , Belenkov Yu. N. 
Published: July 2021

Aim. To study the level of serum biomarkers of endothelial dysfunction and myocardial stress in patients with various types of hypertrophic cardiomyopathy (HCM).Material and Methods. 48 patients with hypertrophic cardiomyopathy (27 men and 21 women) were examined, the mean age was 54±13 years. The patients were divided into two groups according to the course options: group 1 - symptomatic stable course (n=14); group 2 - progressive course of symptomatic HCM (n=34). In accordance with the assigned tasks, all patients underwent determination of biological markers of neurohumoral systems in blood serum using immunofluorescence assay analysis: N-terminal fragment of brain natriuretic peptide (NT-proBNP), von Willebrand factor (vWF), endothelin-1, E-selectin with subsequent evaluation and correlation of results with clinical and instrumental characteristics of patients. When performing echocardiography following parameters were assessed: dimensions of the heart chambers, the thickness of the interventricular septum, the thickness of the posterior wall of the left ventricle (LV), LV mass, LV mass index, the ratio between LV filling in diastole (peak E) and atrial systole (peak A)-(E/A), relative myocardial thickness index, left atrial volume index.Results. Both groups showed increased levels of NT-proBNP and endothelin-1. E-selectin and vonWillebrand factor remained within the normal range. There was no statistically significant intergroup difference. There was a correlation between the level of the index of the relative myocardial thickness and the level of NT-proBNP (r=0.30; p=0.04). A correlation was found between the level of the vWF marker and the left atrial volume index (r=0.32; p=0.04). When assessing the association of indicators of intracardiac hemodynamics with other markers (E-selectin and endothelin-1, no statistically significant relationships were found.Conclusion. In the course of the research, it was found that the high activity of endothelin-1 and NT-proBNP reflects endothelial dysfunction and myocardial stress in patients with HCM, especially in patients with a progressive variant of HCM. However, we did not find any changes in the levels of E-selectin and von Willebrand factor, as well as their intergroup differences. These results require additional studies to assess endothelial dysfunction in patients with HCM.
Chronic Heart Failure in Patients with Arterial Hypertension Associated with Obstructive Sleep Apnea Syndrome: Possible Options to Pathogenetic Therapy
Authors: Yakovlev A. V. , Shilov S. N. , Berezikova E. N. , Yakovleva N. F. , Teplyakov A. T. , Grakova E. V. , Kopeva K. V. , Efremov I. A. 
Published: July 2021

Aim. To study approaches to the treatment of chronic heart failure (CHF) with reduced and mid-range left ventricular ejection fraction (LVEF) in patients with arterial hypertension (AH) against the background of obstructive sleep apnea (OSA).Material and methods. The study included 136 patients with CHF and AH. Inclusion criteria for the study: 1) moderate and severe OSA (with an apnea/hypopnea index of more than 15 per hour); 2) II-IV functional class of CHF according to NYHA; 3) the level of brain natriuretic peptide precursor (NT-proBNP) ≥125 pg/ml; 3) LVEF <50%; 4) the duration of hypertension is at least 2 years. Patients received drug therapy, including beta-blockers, mineralocorticoid receptor antagonists, diuretics, ACE inhibitors or angiotensin receptor inhibitors or valsartan/sacubitrile. After 12 months of followup, the patients were divided into 2 groups depending on the medication being administered. Group 1 included patients (n = 50) receiving therapy with valsartan/sacubitril, group 2 included patients (n = 86) receiving therapy without this drug. Effective CPAP-therapy also was registered in each group.Results. In patients with CHF who received valsartan/sacubitril, disease progression was recorded in 28% of cases, while in patients who did not receive therapy with this drug, an unfavorable course of CHF was recorded in 42.8% (p = 0.001). In group 1, the NT-proBNP level significantly (p = 0.034) decreased by 34%, while in group 2, a significant (p = 0.002) increase in biomarker levels was revealed by 35.5%. In the group of patients receiving therapy with valsartan/sacubitril an increase in LVEF (p = 0.007) was revealed by 12.5%. In group 1, an increase in exercise tolerance was achieved in the form of a significant (p = 0.012) increase in the distance of the six-minute walk test by 18.2%, while in group 2, the six-minute walk distance decreased by 19.2% (p = 0.034). In the subgroup of patients receiving CPAP therapy in combination with valsartan/sacubitril therapy (n=8), LVEF increased by 11.6% (p = 0.043), the six-minute walk test distance increased by 29.7% (p = 0.046), and NT-proBNP decreased by 22.5% (p = 0.039), while in the group of patients who received only CPAP therapy (n=19).Conclusion. The most significant slowdown in the rate of progression of CHF in patients with AH associated with OSA, an increase in exercise tolerance, as well as the most pronounced tendency to the reverse development of pathological echocardiographic changes in the myocardium when using valsartan/sacubitrile in drug therapy in combination with effective hardware CPAP therapy.
Thrombolytic Therapy in Treatment in Patients with Pulmonary Embolism not High-risk: SIRENA Registry Data
Authors: Cherepanova N. A. , Mullova I. S. , Pavlova T. V. , Erlikh A. D. , Barbarash O. L. , Berns S. A. , Schmidt E. A. , Duplyakov D. V. 
Published: July 2021

Aim. To study the features of the use of thrombolytic therapy (TLT) in normotensive patients with pulmonary embolism (PE) in real clinical practice in Russian hospitals.Material and Methods. From 04/1 5/2018 to 04/15/2019 patients hospitalized with a diagnosis of PE consistently were included in the Russian multicenter observational prospective register "SIRENA” (RusSIan REgistry of pulmoNAry embolism).Results. For 12 months in the registry was included 609 patients with a lifetime confirmed diagnosis of PE. TLT was performed in 152 patients with PE (25.0%), of which only 51 (33.8%) were indicated as "high risk" (shock or hypotension). In 101 not high risk patients, the indications for TLT were: severe shortness of breath/respiratory failure - 19 (18.8%), massive venous thrombosis - 7 (6.9%), signs of massive/submassive PE - 10 (9.9%), intermediate-high risk - 14 (13.9%), suspicion of acute coronary syndrome with ST segment elevation - 3 (2.9%), high pulmonary hypertension -2 (2.0%). The other 46 (45.5%) non-high-risk patients had no clear indication of the reasons for TLT in their medical history. To study the features of management of patients with not high-risk PE who received TLT (group 1), a selection of pairs of patients from the "SIRENA” registry, comparable in gender and age, in a ratio of 1:1 of patients with not high-risk PE who did not perform TLT (group 2). Hospital mortality was 4 (4%) patients in the TLT group and 6 (5.9%) patients in group 2 (р=0,748). Logistic regression analysis showed that floating blood clot in the veins of the lower extremities, syncopes in the debut of PE, respiratory rate over 22 per minute were independent clinical factors that significantly influence the doctor's decision to perform thrombolysis, and probability of completion TLT decreased in the presence of a history of bleeding, chronic kidney disease, surgery in the previous 12 months, increase in the size of the right atrium on EchoCG (statistical significance of the model x2=51.574; p<0.001). The development of bleeding during hospitalization was recorded only in 10 (9.9%) patients of group 1, including severe (3 stage on the BARC scale) in 2 patients. Patients without TLT more often developed an acute heart failure (25.9% vs. 8.5%, p=0.043).Conclusion. In real clinical practice, there is a high frequency of TLT in patients with not high-risk PE. Floating blood clot in the veins of the lower extremities, syncope in the debut of PE, respiratory rate over 22 per minute were independent clinical factors that significantly influence the doctor's decision to perform thrombolysis.
Avulsion Injuries and Ruptures of the Proximal Rectus Femoris in Skeletally Mature, High-Level Athletes
Authors: Knapik Derrick M. , Trasolini Nicholas A. , Diaz Connor C. , Chahla Jorge , Forsythe Brian 
Published: July 2021

» Injuries to the proximal rectus femoris remain rare, occurring primarily in soccer and American football athletes during kicking and sprinting because of its unique biarthrodial nature.» The appropriate diagnosis is dependent on careful physical examination and imaging interpretation.» While no universal treatment algorithm has been adopted for high-level athletes, recent investigations support operative repair using suture anchors to restore strength and function in order to allow an effective return to competition while minimizing the risk of injury recurrence.» Complications following surgical management include injury to the lateral femoral cutaneous nerve and hematoma formation, and there are reports of residual pain and weakness with chronic injuries that fail the initial nonoperative treatment.» Current investigations examining outcomes following treatment remain limited, warranting additional studies that examine patient-reported results, return-to-play rates, and the role of orthobiologics and accelerated rehabilitation protocols following injury to further improve athlete health and safety.