bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of opioid-related aberrant behaviors predicted by Opioid Risk Tool among cancer patients receiving opioid analgesics
Authors: Oh So Yeon , Park Kwonoh , Koh Su-Jin , Kang Jung Hun , Chang Myung Hee , Lee Kyung Hee 
Published: April 2021

Abstract
Purpose: The risk of opioid-related aberrant behavior (OAB) in Korean cancer patients has not been previously evaluated. The purpose of this study was to investigate the Opioid Risk Tool (ORT) in Korean cancer patients receiving opioid treatment.Methods: Data were obtained from a multicenter, cross-sectional, nationwide observational study regarding breakthrough cancer pain. The study was conducted in 33 South Korean institutions from March 2016 to December 2017. Patients were eligible if they had cancer-related pain within the past 7 days, which was treated with strong opioids in the previous 7 days.Results: We analyzed ORT results of 947 patients. Only one patient in each sex (0.2%) was classified as high risk for OAB. In patients with an ORT score of 1 or higher, the score primarily represented positive responses for personal history of depression, personal or family history of alcohol abuse, or 16–45 years age range. These patients had more severe average and worst pain scores and used rescue analgesics more frequently than patients with ORT scores of 0. The proportion of moderate- or high-risk patients according to ORT was lower in patients receiving low doses of long-acting opioids than in those receiving high doses (2.0% vs. 6.6%, p = 0.030). Moderate or high risk was more frequent when ORT was completed in an isolated room than in an open, busy place (2.7% vs. 0.6%, p = 0.091).Conclusion: The risk of OAB measured by ORT was very low in cancer patients receiving strong opioids for analgesia.
Dynamic Changes of miRNAs in Skeletal Muscle Development at New Zealand Rabbits
Authors: Jing Jing , Jiang Xichun , Zhu Cuiyun , Zheng Qi , Ji Qianyun , Yin Huiqun , Huang Jingtong , Zhu Yixiao , Wang Jiao , Qin Shuaiqi , Ling Yinghui 
Published: April 2021

Abstract
Background: miRNA is one of the crucial roles in the complex and dynamic network that regulates the development of skeletal muscle. The landscape of skeletal muscle miRNAs from fetus to adult in New Zealand rabbits has not been revealed yet.Results: In this study, nine sRNA-seq libraries of fetus, child and adult rabbits’ leg muscles were constructed. A total of 278 differentially expressed miRNAs (DEmiRNAs) were identified. In the fetus vs. child group, the main functional enrichments were involved in membrane and transport. Pathway enriched terms of up-regulated DEmiRNAs were connected with the differentiation and hypertrophy of skeletal muscle, and down-regulated ones were related to muscle structure and metabolic capacity. In the child vs. adult group, functions were associated to positioning and transportation, and pathways were relevant to ECM, muscle structure and hypertrophy. Finally, ocu-miR-185-3p and ocu-miR-370-3p, which had the most target genes, were identified as hub-miRNAs in these two groups.Conclusion: In summary, we summarized the highly expressed and uniquely expressed DEmiRNAs. Besides, the potential functional changes of miRNAs in two consecutive stages have been explored. Among them, the ocu-miR-185-3p and ocu-miR-370-3p with the most target genes were selected as hub-miRNAs. These data improved the understanding of the regulatory molecules of meat rabbit development, and provided a novel perspective for molecular breeding of meat rabbits.
Whole Exome Sequencing Identifies a Novel COL1A1 Missense Mutation Causing Dentinogenesis Imperfecta Type I Without Skeletal Abnormalities
Authors: Zeng Yuting , Pan Yuhua , Mo Jiayao , Ling Zhiting , Jiang Lifang , Xiong Fu , Yan Wenjuan 
Published: April 2021

Abstract
Background：Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, blue sclerae and dentinogenesis imperfecta (DGI), which are mainly caused by a mutation of the COL1A1 or COL1A2 genes that encode type I procollagen.Methods: The ultrastructure of dentin was analyzed by micro-CT, scanning electron microscopy, energy-dispersive spectroscopy analysis, nanoindentation test and Toluidine Blue Staining. Whole-exome sequencing (WES) was performed to identify the pathogenic gene. The function of the mutant COL1A1 was studied by real-time PCR, western blotting, subcellular localization. Functional analysis in dental pulp stem cells (DPSCs) was also performed to explore the impact of the identified mutation on this phenotype. Results: WES identified a missense mutation (c.1463G > C) in exon 22 of the COL1A1 gene. However, the cases reported herein only exhibited DGI-I in the clinical phenotype, there is no bone disease and any other common abnormal symptom caused by COL1A1 mutation. In addition, ultrastructural analysis of the tooth affected with non-syndromic DGI-I showed that the abnormal dentin was accompanied by disruption of odontoblast polarization, reduced numbers of odontoblasts, loss of dentinal tubules, and reduction in hardness and elasticity, suggesting severe developmental disturbance. What’s more, the odontoblast differentiation ability based on DPSCs that were isolated and cultured from the DGI-I patient was enhanced compared with those from an age-matched, healthy control.Conclusion: This study helped the family members to understand the disease progression and provided new insights into the phenotype-genotype association in collagen-associated diseases and improve clinical diagnosis of OI/DGI-I.
Big Data Tracking and Automatic Measurement Technology for Unmanned Aerial Vehicle Trajectory Based on MEMS Sensor
Authors: Xing Jun , Wang Xinzhe , Dong Jie 
Published: April 2021

Abstract
Due to the high cost and large error of traditional UAV big data tracking and automatic measurement technology, a method of big data tracking and automatic measurement for UAV trajectory based on MEMS sensor was put forward. The iterative learning control algorithm was used to estimate the repetitive disturbance and modeling error of system based on the simplified dynamics model of four-rotor helicopter and the optimal estimation characteristics of Kalman filter. The discrete equation of quadratic performance function in time domain was selected to compensate the estimated model error disturbance, and then the big data tracking was completed. Based on the data of gyroscope, the quaternion differential equation was established. The differential equation was solved by first-order Picard method, and a set of quaternion data was obtained. The gradient descent method was used to process the acceleration data and magnetic data, and thus to get the optimal quaternion. Finally, the measurement results were obtained by fusing the two quaternions with MEMS sensors. Simulation results prove that the proposed method can obtain the trajectory tracking data and measurement information of UAV accurately.
An enhanced approach for optimizing mathematical and structural problems by combining PSO, GSA and gradient directions
Authors: Salajegheh Farsad - , Salajegheh Eysa , Shojaee Saeed - 
Published: April 2021

Abstract
In this paper, the combination of particle swarm optimization (PSO) and gravitational search algorithm (GSA) is enhanced by the first-order gradient method and a new optimization algorithm is introduced as GPSG. In metaheuristic methods, some search directions are selected at random and the resulting points gradually progress toward the optimal. Since the gradient direction usually has the largest decrease in the desired function, it is added to the GSA and PSO process to allow for faster and more accurate convergence. By integrating the metaheuristic methods with the gradient directions, a powerful method for optimizing functions has been made possible. Numerous examples of unconstrained problems of mathematical functions of CEC2005 and constrained examples of stress and displacement structural design problems have been chosen to demonstrate the reliability and capability of the presented method.
Comparison between Amulet and Watchman left atrial appendage closure devices: A real-world, single center experience.
Authors: Saad Mohammed , Risha Osama , Sano Makoto , Fink Thomas , Heeger Christian-Hendrik , Vogler Julia , Sciacca Vanessa , Eitel Charlotte , Stiermaier Thomas , Joost Alexander , Keelani Ahmad , Fuernau Georg , Meyer-Saraei Roza , Kuck Karl-Heinz , Eitel Ingo , Tilz Roland Richard 
Published: April 2021

Abstract
Objectives
To compare the Watchman™ versus Amulet™ left atrial appendage closure (LAAC) devices in a consecutive, industry-independent registry.
Background
Data reporting a head-to-head comparison between Amulet and Watchman devices are scarce.
Methods
Patients who underwent LAAC using Watchman or Amulet devices from January 2014 to December 2019 at the University Heart Center Lübeck, Lübeck, Germany were included in the present analysis. Primary endpoints included periprocedural complications (in-hospital death, pericardial tamponade, device embolization, stroke, major bleeding and vascular access complications), and complications during 2-year-follow-up (ischemic stroke, hemorrhagic stroke, thromboembolism, device thrombus, bleeding and death).
Results
After matching the patients for age (± 5 years), gender, CHA2DS2Vasc score (± 1) and HASBLED score (± 1), each of the Watchman and the Amulet groups included 113 patients. Patients in the Amulet group had significantly more periprocedural complications (2.7% vs 10.6%, p = 0.029; respectively) and more major bleeding complications (0% vs 5.3%, p = 0.029; respectively). During 2-year follow-up, the rate of events was comparable between the Watchman and Amulet groups (18.3% versus 20.8%, p = 0.729; respectively).
Conclusion
Amulet LAAC device was associated with increased periprocedural complications as compared to Watchman LAAC device. On 2-year follow-up, both devices showed comparable efficacy and safety.
The perspectives and experiences of physiotherapists and general practitioners in the use of the STarT Back Tool Tool: A review and meta- synthesis
Authors: Hill Julia , Try Freya , Agnew Georgia , Saywell Nicola 
Published: April 2021

Abstract
Background: Chronic low back pain is associated with disability and work absence. Stratified primary care management of acute low back pain using a prognostic screening tool (STarT Back Tool, SBT) triages people with LBP into targeted treatment groups, matched to their level of risk of chronicity. The SBT was designed for use in the health service in the United Kingdom (UK) where it has been shown to improve clinical outcomes, patient satisfaction, and reduce treatment costs and time off work. Successful implementation of the SBT in health care outside the UK is dependent on the health practitioners who will use it and the healthcare system in which they work. Gaining health practitioners’ perspectives on the SBT is an important step in effective implementation. Methods: A computerised search of qualitative literature was conducted across seven databases in March 2021 using keywords to identify studies that investigate the perspectives of physiotherapists and general practitionners on the use of the SBT in primary health care. Study quality was assessed using the CASP tool. Data were coded and analysed using reflexive thematic analysis. Results: Eight articles met the inclusion criteria and included the views of general practitioners and physiotherapists from primary health care settings from four countries. Three overarching themes were created from the data, the first ‘making it work’, identifies factors that may influence implementation and continued use of the SBT in clinical practice. The second ‘will I do it?’, captured potential consequences of adopting the SBT and the third ‘it’s all about the patient’ emphasised how the SBT may affect patients and their potential reactions to risk stratification and matched treatments.Conclusions: Physiotherapists and general practitioners found using the SBT frequently enhanced their practice. General practitioners did express concerns about time constraints and the potential for the SBT to undermine their clinical experience. Findings from this study will inform modifications to contextualise the tool to each healthcare environment.
A New Specific Sequence to Distinguish B.canis From Other Brucella by PCR
Authors: YE YinBo , YANG JiangHua , LI DongLiang , HAO LiHua , ZHANG Zhao , MEI SiYao , ZHANG Huan , DU FangYuan , LIU BaoShan , CHEN ZeLiang 
Published: April 2021

Abstract
Background: Brucellosis is a zoonotic disease worldwide. The increasing number of pet dogs has raised new risk of people getting canine brucella with absent or mild symptom. Besides, the canine brucellosis can be caused by other brucella species, so their infection could be omitted by the PCR method. The present PCR methods can only detect canine brucella, by which cases infected with other brucella would appear negative. It’s an urge to develop a specific PCR assay for detecting canine Brucellosis, Whether the pathogen was B.canis or any other Brucella.Resaults: a differential sequence of B.canis were found by genome comparison analysis and were analyzed by BLAST. Then a PCR method was established using specific primers in the sequence and tested for clinical application. It could detect canine brucellosis caused by B.canis or other Brucella species with 310-bp and 413-bp product, respectively. The developed PCR method had specificity for non-brucella and a sensitivity of 100 copies of Brucella DNA. The detection accuracy verified with spiked samples was 95.5% (21/22) for B.canis and 100% (22/22) for other brucella. Conclusions: The study found a specific sequence of B.canis and developed a PCR detection method to detect canine brucellosis caused by B.canis or other Brucella species. The method established in this study will more comprehensively detect the pathogen of canine brucellosis and provide important methods and means for preventing and controlling this disease.
Deep learning shows declining groundwater levels in Germany until 2100 due to climate change
Authors: Wunsch Andreas , Liesch Tanja , Broda Stefan 
Published: April 2021

Abstract
In this study we investigate how climate change will directly influence the groundwater resources in Germany during the 21st century. We apply a machine learning groundwater level prediction framework, based on convolutional neural networks to 118 sites well distributed over Germany to assess the groundwater level development under the RCP8.5 scenario, based on six selected climate projections, which represent 80% of the bandwidth of the possible future climate signal for Germany. We consider only direct meteorological inputs, while highly uncertain anthropogenic factors such as groundwater extractions are excluded. We detected significant declining trends of groundwater levels for most of the sites, revealing a spatial pattern of stronger decreases especially in the northern and eastern part of Germany, emphasizing already existing decreasing trends in these regions. We can further show an increased variability and longer periods of low groundwater levels during the annual cycle towards the end of the century.
The role of poly-herbal extract in sodium chloride-induced oxidative stress and hyperlipidemia in male Wistar rats
Authors: Fadahunsi Olumide , Adegbola Peter , Akintola Olayemi Adebola , Ajilore Bamidele Stephen , Olorunnisola olubukola sinbad 
Published: April 2021

Abstract
Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Thirty-five male Wistar rats were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat and 16 % high salt diet only respectively. Animals in groups 3, 4, and 5 were fed 16% high salt diet with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE) respectively once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. PHE (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentration and increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.
First Complete Genome Sequence of Brucella abortus 2308 isolated from an abortion storm in a dairy farm in India
Authors: Kumar Amit , Prajapati Malyaj R , Upadhyay Surendra , Bhordia Anamika , Singh Vinod Kumar , Singh Jitender , Kumar Pankaj , Rahal Anu , Kumar Ravindra , Sirohi Anil 
Published: April 2021

Abstract
The present report communicates the first complete genome sequence of Brucella abortus 2308 strain isolated from a an abortion storm in a dairy farm located at Kanpur, Uttar Pradesh in India. It caused the last trimester abortions of 32 animals out of 100 cows in a dairy over a period of 60 days. The bacteria were isolated in pure culture from the placenta of aborted cows. The genome sequence length of isolated bacteria is 3,285,606 bp with a 57.25 % GC content, an N50 value of 296,426, L50 value of 4 containing 3,119 coding DNA sequences (CDSs), 49 tRNAs, 1 transfer messenger RNA (mRNA), and 3 rRNA genes. It is the first report of Brucella abortus 2308 isolation and complete genome sequence from Indian subcontinent.
Ethical and Practical Considerations for Cell and Gene Therapy Toward an HIV Cure: Findings from a Qualitative In-Depth Interview Study in the United States
Authors: Dubé Karine , Kanazawa John , Patel Hursch , Louella Michael , Sylla Laurie , Sheehy Jeff , Dee Lynda , Taylor Jeff , Sauceda John A. , Peluso Michael J. , Deeks Steven G. , Simoni Jane 
Published: April 2021

Abstract
Background: HIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify standards, safeguards, and protections to ensure cell and gene therapy HIV cure research remains ethical and acceptable to as many stakeholders as possible as it advances on a global scale.Methods: To elicit ethical and practical considerations to guide cell and gene therapy HIV cure research, we implemented a qualitative, in-depth interview study with three key stakeholder groups in the United States: 1) biomedical HIV cure researchers, 2) bioethicists, and 3) community stakeholders. Interviews were transcribed verbatim. We applied conventional content analysis focused on inductive reasoning to analyze the rich qualitative data and derive key ethical and practical considerations related to cell and gene therapy towards an HIV cure.Results: We interviewed 13 biomedical researchers, 5 community members, and 1 bioethicist. Informants generated considerations related to: perceived benefits of cell and gene therapy towards an HIV cure, perceived risks, considerations necessary to ensure an acceptable benefit/risk balance, cell and gene therapy strategies considered unacceptable, additional ethical considerations, considerations for first-in-human cell and gene therapy HIV cure trials. Informants also proposed important safeguards to developing cell and gene therapy approaches towards an HIV cure, such as the importance of mitigating off-target effects, mitigating risks associated with long-term duration of cell and gene therapy interventions, and mitigating risks of immune overreactions.Conclusion: Rapidly evolving cell and gene therapy towards an HIV cure is accompanied by a host of ethical and practical challenges. To minimize risks to potential participants and facilitate the translation of scientific advancements from the bench to the clinic, cell and gene therapy HIV cure research must be thoughtfully developed and implemented. To protect the public trust in cell and gene therapy HIV cure research, ethical and practical considerations should be periodically revisited and updated as the science continues to evolve.
Transcriptome Analysis of Tailfins From Grass-Goldfish And Egg-Goldfish to Identify Genes Involved in Artificial Selection for Ornamental Purposes
Authors: Wang Shu-yan , Liu Nai-yi , Fang Jie 
Published: April 2021

Abstract
Goldfish, one of the first animals domesticated for ornamental purposes, experience huge morphological variation, of which the number changes in tailfins and the loss of dorsal fins is the most impressive due to their important functions in fish. In the present study, a transcriptome analysis of the tailfins of Grass- (with complete dorsal fin and a single tailfin), and Egg-goldfish (loss of dorsal fin and double tail fins) was carried out to determine the sequence variants, to detect differential gene expression patterns in transcriptomes, and to characterize the effects of selection and identify target genes under selection. In total, 124,808,475 and 101,965,939 high quality reads were obtained from the tailfins of Grass- and Egg-goldfish, respectively, and 114,796 unigenes were further assembled from over 33.48 Gb nucleotides. A large portion of unigenes related to various primary and secondary metabolite pathways were identified, and the differentially expressed genes (DEGs) between the tailfins from Grass- and Egg-goldfish were also generally enriched in the metabolite pathways, for instant, the PI3K−Akt signalling pathway, the MAPK signalling pathway, osteoclast differentiation, and the dorso-ventral axis formation, all relating to cell proliferation, growth, and differentiation. These identified DEGs (HOXA2b, HOXB13a, paired mesoderm homeobox protein 1-like isoform X2 (PRRX2), zinc finger E-box-binding homeobox 1-like isoform X3 (ZEB1), and homeobox protein (Meis1), presumably played an important role in the development of the double tail fins during the artificial selection for ornamental purposes.
A meritocratic network formation model for the rise of
social media influencers
Authors: Pagan Nicolò , Mei Wenjun , Li Cheng , Dörfler Florian 
Published: April 2021

Abstract
Many of today’s most used online social networks such as
Instagram, Youtube, Twitter, or Twitch are based on User-Generated Content (UGC), and the exploration of this content is enhanced by the integrated search engines. Prior multidisciplinary effort on studying social network formation
processes has privileged topological elements or socio-strategic incentives. Here, we propose an untouched meritocratic approach inspired by empirical evidence on Twitter data: actors continuously search for the best UGC provider. We statistically and numerically analyze the network equilibria properties: while the expected outdegree of the nodes remains bounded by the
logarithm of the network size, the expected indegree follows a Zipf’s law with respect to the quality ranking. Notably, our quality-based mechanism provides an intuitive explanation of the origin of the Zipf’s regularity in growing social networks. Our
theoretical results are empirically validated against large data-sets collected from Twitch, a fast-growing platform for online gamers.