bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of different sheet compositions and commercial adhesives on the performance of multilaminated plywood
Authors: Setter Carine , Zidanes Uasmim Lira , Miranda Eduardo Hélio de Novais , Brito Flávia Maria Silva , Mendes Lourival Marin , Junior José Benedito Guimarães 
Published: February 2021

Abstract
The quality of plywood panels depends on factors such as the forest species and the adhesive used in their production, and understanding the interferences of these factors in the final properties of the plywood is of fundamental importance. The study aimed to develop multilaminate plywood panels with two forest species and two types of adhesive and to evaluate the influences of these factors (forest species and adhesive) on the physical and mechanical properties of the plywood. The panels were produced with sheets of parica and pine with two types of adhesives, urea-formaldehyde and phenol-formaldehyde, with a weight of 150 g/cm². Then, each set was pressed for 10 minutes under a specific pressure of 0.98 MPa at a temperature of 150 °C. Three panels were produced for each type of blade and adhesive, totaling four treatments. The plywood was evaluated for physical properties (humidity, bulk density, and water absorption) and mechanical properties (parallel and perpendicular static flexion and resistance to mechanical shear). The results showed that the forest species had a greater influence on physical and mechanical properties, with the best results being observed for plywood produced with pine. The panels with sheets of parica and phenol-formaldehyde adhesive showed less moisture. The apparent density of the panels should be considered as it positively influenced the mechanical properties and negatively impacted water absorption. It is concluded that the plywood produced can be used for internal and external applications. However, it is indicated for structural purposes as it did not meet the requirements of the NBR 31.000.001/2:2001.
Novel Concept on the Enhancement of Conventional Solar Still Performance via Constant Heat Rate Supply to the Saline Water&nbsp;
Authors: El-Maghlany Wael M. , massoud enass , Elhelw mohamed 
Published: February 2021

Abstract
One of most reduction reasons of simple conventional solar still productivity is the coupling between high solar intensity and the high ambient temperature in the same time. The high intensity increases the saline water temperature while the outside temperature increases the glass temperature and consequently reduction in saline water and glass temperature difference leads to reduction in condensation and productivity. The present theoretical study focuses on the completion of the absorbed solar energy in the basin to be constant during the day. The basin water will be in high temperature level all day especially at the time of low outside temperature far away the noon. The absorbed heat in the basin is held constant at αw Imax by extra heat from wind turbine power with battery storage system all day hours. The results show that, the solar still productivity with constant heat supply is more than that with same amount of variable energy during sun rise time only (6 AM to 6 PM) by 69.133 %. So, constant absorbed heat in the water basin (αw Imax) through the 24 hr of the day enhances the performance with productivity up to 248 % with the hybrid solar and electric power consumption of the wind turbine power. The water in the basin is held constant at 2 cm via makeup water to compensate the evaporation rate.
Determinants of Preconception care among Pregnant Women In an Urban and a Rural Health Facility In Kenya: A Qualitative Study
Authors: Okemo Joan Khavugwi , Kamya Dorothy , Mwaniki Abraham Mukaindo , Temmerman Marleen 
Published: February 2021

Abstract
BACKGROUNDPreconception care (PCC) is a form of preventive health care that is offered to women and couples before conception, with the aim of improving their health status and mitigating various risk factors that could contribute to poor maternal and child health outcomes. The levels of PCC utilization are still low globally, especially in developing countries and in the rural areas. Little is known regarding PCC use in Kenya that could help in bridging this gap. This study aimed to assess the determinants of PCC in urban and rural settings in Kenya.METHODSSelected pregnant women seeking antenatal care (ANC) were recruited by purposive sampling at the Mother and Child Health (MCH) clinics in Aga Khan University Hospital, Nairobi (AKUH, N-urban) and Maragua Level Four Hospital (MLFH-rural). A qualitative approach was employed to assess determinants of PCC using a semi-structured interview guide. The interviews were transcribed verbatim and analyzed thematically.RESULTS A total of 26 women were invited, of whom 21 accepted to participate in in-depth interviews (IDIs). Saturation of themes occurred after 13 interviews (7 at AKUH and 6 at MLFH).Transcription, coding and thematic analysis of the IDIs yielded 12 main themes. Eleven of the main themes were identified as determinants of PCC while the twelfth theme contained suggested strategies of increasing PCC awareness and utilization, such as using the media, setting up PCC clinics and integrating PCC into other clinics. The dominant themes were awareness about PCC and attitudes towards PCC and pregnancy.The broad determinants of PCC were similar in urban and rural settings – with a few notable exceptions. For example, in the rural setting, women’s level of education and a pervasive history of poor interactions with healthcare providers were major determinants of PCC.CONCLUSIONFrom this study we conclude that women’s lack of awareness about PCC, in conjunction with attitudes towards PCC and pregnancy impact strongly on its utilization. This lack of awareness could be addressed through health education programs for both the public and for healthcare providers, as well as integrating PCC in the curricula of nurses and doctors.
The Role of FDX1 in Granulosa Cell of Polycystic Ovary Syndrome (PCOS)
Authors: wang zhi , Dong Hui , Yang Li , Yi Ping , Wang Qing , Huang Dongmei 
Published: February 2021

Abstract
Background: To explore the development mechanism of PCOS and Transcriptomics was applied to seek the key gene.Methods: Transcriptomics marked by UID (unique identifier) technique of granulosa cell in PCOS and control women was measured. RT-PCR was applied to verify the key gene. Two kinds of PCOS models modeling with Letrozole and Testosterone Propionate were applied to verify the key gene of granulosa cell in PCOS. Results: The outcome of GO-enrich of transcriptomics concentrated in steroid metabolism and mitochondria. The different genes were sought from coexisting in both steroid and mitochondria. Finally, five different genes including CYP11A1、CYB5R1、STAR、FDX1 and AMACR were obtained. RT-PCR was administrated to furtherly verify the downregulating FDX1 in PCOS, which showed the consistent outcome with the transcriptomics. FDX1 in granulosa cell of antral follicle in both PCOS model rats was measured and was lower than control rats, which was consistent in two kinds of PCOS models. Conclusion: FDX1 was related with steroid metabolism and mitochondrial and may participate in the development of PCOS.
Two novel biallelic mutations in PSMC3IP in a Chinese patient affected by primary ovarian insufficiency: case report and review of the literature
Authors: Mei Libin , Huang Lingling , Huang Yanru , Wu Xiaoling , He Huang , He XueMei , Su Zhiying , Li Ping 
Published: February 2021

Abstract
Background: Premature ovarian insufficiency (POI) is a heterogeneous condition occurring when a woman experiences a loss of ovarian activity before the age of 40. It is one of the most common reproductive endocrine diseases in women of childbearing age. Here, we investigated the clinical manifestations and genetic features of a Chinese patient affected by POI.Methods: We applied next-generation whole-exome capture sequencing with Sanger direct sequencing to the proband and her clinically unaffected family members. Results: Two novel compound heterozygous mutations were identified in the PSMC3IP gene. The first is a splicing mutation (c.597+1G>T) that was inherited from her father, while the second mutation (c.268G>C p.D90H) was also discovered in her mother and younger sister. The two mutations were co-segregated with the disease phenotype in the family. Conclusions: To our knowledge, this is the first report of PSMC3IP mutations causing POI in the Chinese population. Our findings further support the key role of the PSMC3IP gene in the etiology of POI. However, additional studies are required to explore the underlying molecular mechanisms involved.
Patient’s perspective regarding the elective surgical procedure during Covid 19 pandemic.
Authors: Badkur Mayank , Puranik Ashok , Sharma Naveen , Baskaran Suruthi 
Published: February 2021

Abstract
Context: The ongoing Covid-19 pandemic and the subsequent nationwide lockdown, has impacted all aspects of society including the medical profession. In hospitals, the focus has mainly shifted to prevention and treatment of Covid-19 infection. Owing to this, all elective surgeries are being postponed and only emergent surgeries are being performed. This has affected the patients differently depending on the progression of disease and development of complications.Methods and Material: A well-structured telephonic scripted questionnaire was administered to all patients who were given an appointment for any elective surgery. Data was collected regarding the status of disease including complications and the patient’s perspective on the method of treatment. Patients who developed complications or underwent emergency surgery or surgery elsewhere were excluded.Statistical analysis used: Collected data was entered in MS Office Excel spreadsheet and analysis was done using SPSS software.Results: The man to women ratio was 2.3:1. The mean age of patients was 41.16 years. A total of 86 patients were included in the study. Almost all (98.8%) were aware that the lockdown and withholding of elective surgeries were directed to prevent the spread of coronavirus infection. Among 34 patients with progressive disease, 88.2% were willing to undergo the surgical procedure and 73.5% were willing to visit hospital within a week or two. Among 46 patients, who were Willing to continue the treatment on wait and watch policy, 45.7% patients wanted to wait for more than 2 months for their treatment, and 93.5% patients were avoiding hospital visit because of infection.Conclusions: Patient’s attitude towards the choice of treatment (wait and watch Vs surgery) mainly depended on the progression of disease. It is critical, during these tough times of Covid-19 pandemic, that risks are weighed against benefits to decide the line of management for patients waiting for elective surgeries.
Environmental DNA provides greater insight to biodiversity and ecosystem function compared to traditional approaches, via spatio-temporal nestedness and turnover partitioning
Authors: Seymour Mathew , Edwards Francois , Cosby Jack , Scarlet Pete , Bista Iliana , Brailsford Francesca , Glanville Helen , Bruyn Mark de , Carvalho Gary , Creer Simon 
Published: February 2021

Abstract
Rapidly assessing biodiversity is essential for environmental monitoring, however traditional approaches are limited in the scope needed for most ecological systems. Environmental DNA (eDNA) based assessment offers increased scope, while reducing cost and time, compared to traditional methods. Here we investigated the effects of landuse and seasonality on headwater community richness and functional diversity, to assess spatio-temporal dynamics between eDNA and traditional methods. Environmental DNA provided greater biodiversity resolution with both methods resulting in complementary findings. Community richness was seasonally linked, peaking in spring and summer, with temporal turnover having a greater effect on community composition compared to localized nestedness. Our assessment of ecosystem function shows community formation is driven by regional resource availability, implying regional management requirements. Our findings show that eDNA based ecological assessment is a powerful, rapid and effective assessment strategy that enables complex spatio-temporal studies of community diversity and ecosystem function previously unavailable by traditional means.
Intra-mitochondrial disulfide polymerization controls cancer cell necroptosis
Authors: Kim Sangpil , Jana Batakrishna , Go Eun Min , Lee Ji Eun , Jin Seongeon , Sim Youjung , Son Sehee , Kim Dohyun , Kim Chaekyu , Kwak Sang Kyu , Ryu Ja-Hyoung 
Published: February 2021

Abstract
In a biological system, energy-consuming reactions to attain a biological dissipative state are ubiquitous, and mimicking such reactions is a great challenge in synthetic chemistry. Herein, we report an intra-mitochondrial polymerization strategy for constructing macroscopic structures using a reactive oxygen species (ROS)-dissipative system. This is the first time that the occurrence of disulfide polymerization inside cancer mitochondria owing to the high ROS concentration of cancer mitochondria is reported. This polymerization hardly occurred inside cells owing to the intracellular reductive environment. The polymerization process of a thiol-containing monomer further increases the ROS level inside the mitochondria, thereby enabling the autocatalytic process to accelerate polymerization and induce mitochondrial dysfunction. This in-situ polymerization shows great potential for anticancer treatment against various cancer cell lines, including drug-resistant cancer cells.
Withdrawal Notice: S.A.R.S Covid-19 A Medicinal Chemistry Approach
Authors: Bhardwaj Gautam , Tonk Rajiv Kumar , Garg Harish , Bhalla Vijay 
Published: February 2021

The article has been withdrawn at the request of the editor of the journal Mini-reviews in Medicinal Chemistry due to incoherent
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Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease
Authors: Zarini-Gakiye Elahe , Vaezi Gholamhassan , Parivar Kazem , Sanadgol Nima 
Published: February 2021

Background:
In human tauopathies, pathological aggregation of misfolded/unfolded proteins,
particularly microtubule-associated protein tau (MAPT, tau) is considered to be an essential
mechanism that triggers the induction of endoplasmic reticulum (ER) stress.

Objective:
Here, we assessed the molecular effects of natural antioxidant alpha-lipoic acid (ALA)
in human tauR406W (hTau)-induced ER unfolded protein response (ERUPR) in fruit flies.

Methods:
In order to reduce hTau neurotoxicity during brain development, we used a transgenic
model of tauopathy where the maximum toxicity was observed in adult flies. Then, the effects of
ALA (0.001, 0.005, and 0.025% w/w of diet) in htau-induced ERUPR and behavioral dysfunctions
in the ages 20 and 30 days were evaluated in Drosophila melanogaster.

Results:
Data from expression (mRNA and protein) patterns of htau, analysis of eyes external morphology
as well as larvae olfactory memory were confirmed by our tauopathy model. Moreover,
the expression of ERUPR-related proteins involving Activating Transcription Factor 6 (ATF6), inositol
regulating enzyme 1 (IRE1), and protein kinase RNA-like ER kinase (PERK) wase upregulated
and locomotor function decreased in both ages of the model flies. Remarkably, the lower dose
of ALA modified ERUPR and supported the reduction of behavioral deficits in youngest adults
through the enhancement of GRP87/Bip, reduction of ATF6, downregulation of PERK-ATF4 pathway,
and activation of the IRE1-XBP1 pathway. On the other hand, only a higher dose of ALA affected
the ERUPR via moderation of PERK-ATF4 signaling in the oldest adults. As ALA also exerts
higher protective effects on the locomotor function of younger adults when htauR406Wis expressed
in all neurons (htau-elav) and mushroom body neurons (htau-ok), we proposed that ALA
has age-dependent effects in this model.

Conclusion:
Taken together, based on our results, we conclude that aging potentially influences
the ALA effective dose and mechanism of action on tau-induced ERUPR. Further molecular
studies will warrant possible therapeutic applications of ALA in age-related tauopathies.
Intimate Partner Violence: A Literature Review
Authors: Yonfa Erick D.A. , Fasol Malinda , Cueva Camila M. , Zavgorodniaya Anna C. 
Published: February 2021

Background:
Intimate Partner Violence (IPV) is a complex issue that appears to be more prevalent in developing nations. Many factors contribute to this problem.

Objective:
This article aimed to review and synthesize available knowledge on the subject of Intimate Partner Violence. It provides specific information that fills the knowledge gap noted in more global reports by the World Health Organization.

Methods:
A literature search was conducted in English and Spanish in EBSCO and Scopus and included the keywords “Intimate, Partner, Violence, IPV.” The articles included in this review cover the results of empirical studies published from 2004 to 2020.

Results:
The results show that IPV is associated with cultural, socioeconomic, and educational influences. Childhood experiences also appear to contribute to the development of this problem.

Conclusion:
Only a few studies are focusing on empirically validated interventions to solve IPV. Well-implemented cultural change strategies appear to be a solution to the problem of IPV. Future research should focus on examining the results of strategies or interventions aimed to solve the problem of IPV.
An Overview of Removal of Heavy Metal Ions From Toxic Aqueous Solution
Using Pani-Based Adsorbents
Authors: Mohanty Smruti Rekha , Biswal Susanta Kumar 
Published: February 2021

:
In the present time, water pollution has become a quibbling issue in the current environmental
engineering and protection senario. The most important aspect of nanocomposite is to
develop economic and bio-friendly route for the synthesis of nanosamples. Various methods such
as ion exchange, reverse osmosis, filtration, adsorption, etc. for removing the metal ions from toxic
water were studied. Among these methods, adsorption technique is widely used due to low cost.
Basically, over the last years, conducting polymer based nanocomposites showed their application
in different heavy metal ions especially Hg (II), Cd(II), Cr(VI), Pb(II), As(V), etc. Among the various
conducting polymers, PANI plays the most important role in extracting the necessary heavy
metal ions. The current review mainly focuses on the synthesis, adsorption and mechanism of different
PANI-based adsorbents like PANI/iron oxide, PANI/ZNO, PANI/GO, and
PANI/CHITOSAN, etc., which extract the heavy metal ions.
Secure Data Validation and Transmission in Cloud and IoT Through Ban
Logic and KP-ABE
Authors: Kumar Narander , Samriya Jitendra Kumar 
Published: February 2021

Background:
Cloud computing is a service that is being accelerating its growth in the field of information
technology in recent years. Privacy and security are challenging issues for cloud users and providers.

Obective:
This work aims at ensuring secured validation of user and protects data during transmission for users in a public
IoT-cloud environment. Existing security measures however fails by their single level of security, adaptability for large
amount of data and reliability. Therefore, to overcome these issues and to achieve a better solution for vulnerable data.

Method:
The suggested method utilizes a secure transmission in cloud using key policy attribute based encryption (KPABE). Initially, user authentication is verified. Then the user data is encrypted with the help of KP-ABE algorithm.
Finally, data validation and privacy preservation are done by Burrows-Abadi-Needham (BAN) logic. This verified, and
shows that the proposed encryption is correct, secure and efficient to prevent unauthorized access and prevention of data
leakage so that less chances of data/identity, theft of a user is the analysis and performed by KP-ABE, that is access
control approach.

Results:
Here the method attains the maximum of 88.35% of validation accuracy with a minimum 8.78ms encryption
time, which is better when, compared to the existing methods. The proposed mechanism is done by MATLAB. The
performance of the implemented method is calculated based on the time of encryption and decryption, execution time and
validation accuracy.

Conclusion:
Thus the proposed approach attains the high IoT-cloud data security and increases the speed for validation
and transmission with high accuracy and used for cyber data science processing.
Expectations of Continuous Vital Signs Monitoring for Recognizing Complications After Esophagectomy: Interview Study Among Nurses and Surgeons
Authors: van Rossum Mathilde , Leenen Jobbe , Kingma Feike , Breteler Martine , van Hillegersberg Richard , Ruurda Jelle , Kouwenhoven Ewout , van Det Marc , Luyer Misha , Nieuwenhuijzen Grard , Kalkman Cor , Hermens Hermie 
Published: February 2021

Background
Patients undergoing esophagectomy are at serious risk of developing postoperative complications. To support early recognition of clinical deterioration, wireless sensor technologies that enable continuous vital signs monitoring in a ward setting are emerging.

Objective
This study explored nurses’ and surgeons’ expectations of the potential effectiveness and impact of continuous wireless vital signs monitoring in patients admitted to the ward after esophagectomy.

Methods
Semistructured interviews were conducted at 3 esophageal cancer centers in the Netherlands. In each center, 2 nurses and 2 surgeons were interviewed regarding their expectations of continuous vital signs monitoring for early recognition of complications after esophagectomy. Historical data of patient characteristics and clinical outcomes were collected in each center and presented to the local participants to support estimations on clinical outcome.

Results
The majority of nurses and surgeons expected that continuous vital signs monitoring could contribute to the earlier recognition of deterioration and result in earlier treatment for postoperative complications, although the effective time gain would depend on patient and situational factors. Their expectations regarding the impact of potential earlier diagnosis on clinical outcomes varied. Nevertheless, most caregivers would consider implementing continuous monitoring in the surgical ward to support patient monitoring after esophagectomy.

Conclusions
Caregivers expected that wireless vital signs monitoring would provide opportunities for early detection of postoperative complications in patients undergoing esophagectomy admitted to the ward and prevent sequelae under certain circumstances. As the technology matures, clinical outcome studies will be necessary to objectify these expectations and further investigate overall effects on patient outcome.