bluuebunny/crossref_metadata_2025_split huggingface dataset:
AGING IN A GOOD WAY THROUGH THE EYES OF ALASKA NATIVE ELDERS: RESULTS FROM A 16-YEAR CBPR STUDY
Authors: Lewis Jordan , Thompson Lena , Kim Steffi 
Published: January 2025

Abstract
Predominantly Western-based biomedical models of successful aging have been used to research, understand, and explain successful aging among diverse populations. The presenters on this symposium have been exploring successful aging from an Alaska Native perspective or what it means to reach “Eldership,” or age in a good way, in urban and rural communities across the State of Alaska. This symposium will present findings from a 16-year study on Alaska Native successful aging. To learn about aging well among Alaska Natives, we have conducted 162 interviews with community-nominated Elders representing 21 Alaska Native communities in five regions of Alaska. Our team asked Alaska Native Elders what it means to them to age in a good way, what supports them to age where and how they want, and what they want younger people to know about aging in a good way. Dr. Jordan P. Lewis will provide an introductory overview of the 16-year study and share the element of emotional health and generativity. Dr. Steffi Kim will discuss the role of community engagement in successful aging for rural and urban Alaska Native Elders followed by Dr. Lena Thompson discussing the role of spirituality and Native ways of life as supporting their ability to meaningfully age. Dr. Maja Pedersen will discuss the role of physical health, including Indigenous approaches to staying active and aging in a good way. The symposium will conclude with a discussion on the interrelated nature of these themes and how attendees can apply these lessons to their own lives.
DISSECTING THE HETEROGENEITY OF SENESCENCE: PROFILING PRIMARY AND SECONDARY SENESCENT STATES USING SINGLE-CELL AND SPATIAL TRANSCRIPTOMICS
Authors: Neretti Nicola 
Published: January 2025

Abstract
Cellular senescence is a state of irreversible cell cycle arrest, contributing to age-associated tissue function decline due to the accumulation of senescent cells. The Senescence Associated Secretory Phenotype (SASP), a collection of signaling molecules and growth factors secreted by these cells, plays a significant role in the sterile inflammation seen in aging tissues. Recent studies, both in vivo and in vitro, have demonstrated that senescence is a heterogeneous phenotype, varying based on cell type, induction method, and duration of senescence. An important aspect of this heterogeneity is the distinction between primary and secondary senescence; primary senescent cells can induce nearby cells into a secondary senescent state, which shares some markers with primary senescence but differs significantly in others, such as the SASP. In this study, we explore the evolution of primary and secondary senescence over time by profiling individual cells during the early stages of senescence establishment using single-cell transcriptomics. We have developed an AI/ML methodology capable of classifying cells into primary and various forms of secondary senescence. This methodology is compared with existing methods like SenMayo and SenSig, and applied to time-course scRNA-seq data to determine the proportion of cells in different senescent states. Additionally, we present findings on the identification of senescent cells in vivo using spatial transcriptomics to study the aging mouse liver.
LONGITUDINAL TRAJECTORIES OF CAREGIVING BENEFITS AMONG FAMILY CAREGIVERS OF OLDER ADULTS
Authors: Ping Yongjing , Lim-Soh Jeremy , Østbye Truls , Malhotra Rahul 
Published: January 2025

Abstract
Although caregiving is often associated with burden, family caregivers can gain benefits – such as satisfaction, increased self-worth, and improved outlook towards life – from caregiving, which are linked with better care-recipient and caregiver outcomes. Acknowledging the dynamic nature of caregiving, many studies have investigated longitudinal patterns of caregiving burden, but studies on trajectories of caregiving benefits are limited. Furthermore, understanding the heterogeneity in trajectories of caregiving benefits will help identify risk factors linked with trajectories indicating low benefits or protective factors linked with high benefits over time. We conducted group-based trajectory modelling on longitudinal data – gathered at four time points, at six-to-twelve-month intervals – on caregiving benefits (short Positive Aspects of Caregiving scale) from 274 family caregivers of older adults in Singapore. We identified three relatively stable trajectory groups – “fulfilled” (14%, highest benefits), “satisfied” (64%, second highest benefits), and “dissatisfied” (22%, lowest benefits). Relative to caregivers in the “fulfilled” group, those cohabiting with their care-recipients were less likely to be in the “satisfied” group, those more prepared for caregiving or supported by experienced migrant domestic workers were less likely to be in the “dissatisfied” group, and those caring for care-recipients with more behavioral impairments were more likely to be in the “dissatisfied” group. Our findings provide evidence for heterogeneity in trajectories of caregiving benefits, indicate that many caregivers maintain relatively high caregiving benefits over time, and suggest that preparing migrant domestic workers and family caregivers for their caregiving role may contribute towards higher caregiving benefits over time.
COGNITIVE AGING AMONG OLDER LATINOS IN THE US, MEXICO, AND BRAZIL
Authors: Angel Jacqueline , Andrade Flávia , Angel Jacqueline 
Published: January 2025

Abstract
Amidst rapid demographic transitions in the Americas, where dementia prevalence is poised to double by 2050, this symposium offers a crucial exploration of cognitive health in the Americas. Leveraging data from Brazil, Mexico, and the US, it emphasizes understanding measurement, contextual factors, diversity of experiences, and associated costs in addressing this pressing global challenge. Cantu et al. scrutinize how gender influences cognitive assessments in older adults in the US and Mexico, unveiling potential biases in reporting and underscoring the need for accurate diagnosis. Exploring cultural resources among very old Mexican American immigrants, Kim and Silverstein shed light on their impact on psychological and cognitive well-being, highlighting the role of cultural context in shaping health outcomes and offering insights into protective factors against cognitive decline. Estimating the economic impact of dementia, Mudrazija et al. assess lost wages, medical care spending, and unpaid care costs for African American and Latino adults in the US and their caregivers, projecting these costs through 2060. García-Chanes and Lopez-Ortega characterize the sample of older adults in Mexico living with dementia in 2016 and the specific sources of social and economic support they receive. Lastly, Chen et al. examine the association between Internet use and cognitive health among Brazilian older adults, suggesting the potential of technology in promoting cognitive well-being and stressing the importance of innovative approaches in enhancing cognitive health outcomes. By synthesizing diverse perspectives and data sources, this symposium offers invaluable insights for developing targeted interventions and policies to address the challenges posed by dementia.
THE LONG REACH OF SOCIAL RELATIONS: GENDER AND THE SES-HEALTH LINK
Authors: Antonucci Toni , Brauer Simon , Cho Joonyoung , Ghose Urmimala , Ajrouch Kristine 
Published: January 2025

Abstract
Accumulated evidence demonstrates a strong relationship between socioeconomic status (SES) and health. We use longitudinal data over a period of 25 years to examine whether education (an established indicator of SES) predicts baseline health (i.e., intercept at W1) and its temporal change (i.e., slope from W1 through W3) in middle-aged and older adults. We further explore the long reach of social relations by testing whether social relations, particularly of parents with children (at W1), mediate and/or moderate the education–health link. The data are drawn from a regionally representative sample of adults (aged 40–93) in the Detroit area, USA. All analyses are stratified by gender (W1 N=males: 330; females: 468). A series of structural equation models were performed. For females, those with higher education had better health in W1. Their health declined across time and at the same rate as those with lower-education. Further, relationship quality did not mediate or moderate these relationships. Among males, those with higher education had better health in W1. Notably, the health of men with lower-education who had a child with whom they confided and those with higher education had similar health at wave 1. Findings indicate that the health of lower-educated men in the presence of key social supports parallels the advantaged health status of men with higher levels of education earlier in life but diverges later in life. These findings suggest that relationships with children may be a protective factor for the health of men in the lower socioeconomic strata.
A COMMUNITY-ENGAGED APPROACH TO CULTURAL ADAPTATION OF BEHAVIORAL INTERVENTIONS: ENGAGING LATINOS IN RESEARCH
Authors: Quiñones-Cordero Maria , Sörensen Silvia , Hepburn Kenneth , Heffner Kathi 
Published: January 2025

Abstract
Latinos are 1.5 times more likely to develop Alzheimer’s disease and related dementias (ADRD) than non-Hispanic white Americans. Latinos also have the highest prevalence of caring for a loved one with ADRD. They spend more time in caregiving-related activities, have limited social support and access to quality dementia care, and have significantly worse physical and mental health. The paucity of culturally congruent interventions to improve Latino ADRD caregivers’ psychological well-being continues to perpetuate poorer outcomes and disparities among Latino caregivers. While several effective psychoeducation and skill-building caregiver programs have been developed, these interventions lack representation of Latino caregivers. Thus, culturally attuned adaptations and implementation of available interventions for Latinos are needed to address this critical gap. This study engaged community-dwelling older Latinos, including Latino caregivers, and Latino community organization leaders, to collaborate in cultural adaptation of the Tele-Savvy program and clinical trial design. Employing community-engaged approaches, we combined a staged cultural adaptation framework and a locally developed training program to engage Latinos in caregiving research. Nine Latino community members served on a community advisory board (CAB). Members first engaged in a training program to develop knowledge about ADRD and skills in conducting research and cultural adaptation. Following the training, members engaged in cultural adaptation of Tele-Savvy and the design of a future clinical trial to test the adapted intervention with Latino ADRD caregivers. We will discuss preliminary findings from the cultural adaptation work with CAB members and future directions to inform the testing of the adapted Tele-Savvy and its refinement.
AGE-FRIENDLY RESEARCH: EDUCATION AND TOOLS TO ENHANCE INCLUSION OF OLDER ADULTS IN RESEARCH
Authors: Lindauer Allison , De Lima Bryanna , Eckstrom Elizabeth 
Published: January 2025

Abstract
Many common diseases disproportionately affect older adults but research studies under-represent older adults due to recruitment and retention barriers. Geriatric research specialists have designed frameworks and tools to address these challenges but these are not widely disseminated. Based on these frameworks and tools, our team designed an Age Friendly Research synchronous, interactive 6-session webinar series and seven Age-Friendly research tools for research team members at our institution. We recruited 40 research-level employees to participate in the webinar series from October to November 2022 and 21 to pilot test the tools. Webinar participants completed pre- and post-program surveys and post-webinar session surveys in REDCap. Participants who pilot tested the tools completed up to 4 monthly REDCap surveys. Surveys included quantitative (e.g., Likert scale, dichotomous, and 10-point ratings) and open-ended responses related to strengths, limitations, areas for improvement, and intention to implement newly learned information. Webinar participants expressed positive feedback stating they would likely use what they learned and recommend to others. Strengths of the webinar were practical tips, useful tools, and real-world examples. However, more information on industry-sponsored trials was requested. The most utilized tools were the communication guide and Age-Friendly research checklist. Participants appreciated the ease of use, webinar training, and supportive teams for tool implementation but identified lack of time and age-appropriate study populations as key barriers. Overall, the webinar and tools were well-received by participants. Sharing the webinar and tools with others could lead to more Age-Friendly research and improve the experience for researchers and older adults alike.
THE ROLE OF SOCIAL DISCONNECTION AND THE NEIGHBORHOOD EXPOSOME IN COGNITIVE DECLINE AMONG BLACK AMERICANS
Authors: Nguyen Ann , Qin Weidi , Taylor Harry 
Published: January 2025

Abstract
The aims of this study were to 1) identify cognitive status trajectories among middle-aged and older Black adults; 2) determine whether baseline loneliness, social isolation, and neighborhood characteristics predicted cognitive status trajectories; and 3) determine whether neighborhood characteristics modified the association between loneliness, social isolation, and cognitive status trajectories. Data for the study came from Black participants aged 51+ in the Health and Retirement Study (N=1791). Cognitive status was measured using the modified Telephone Interview for Cognitive Status; loneliness was measured using the modified UCLA Loneliness Scale. Social isolation from extended family, children, and friends were measured using indicators of network size, contact, and social support for each social group. Neighborhood physical disadvantage and social cohesion were each assessed using a 4-item scale. Group-based trajectory analysis was used. The results indicated that there were four distinct cognitive status trajectories—very low and declining, low and declining, moderate and stable, and high and stable. Higher loneliness scores were predictive of membership in the low and declining trajectory rather than the high and stable trajectory. A significant interaction between neighborhood physical disadvantage and loneliness indicated that the association between loneliness and membership in the low and declining trajectory was weaker among participants who lived in neighborhoods with high levels of physical disadvantage than participant who lived in neighborhoods with low levels of physical disadvantage. These findings have implications for practice with older Black adults and suggest that practitioners should consider the role of loneliness and the neighborhood environment.
SOCIAL JET LAG: SOCIODEMOGRAPHIC DETERMINANTS AND HEALTH IMPLICATIONS IN MIDDLE-AGED AND OLDER ADULTS
Authors: Skoblow Hanamori , Tracy Eunjin , Kim Eunjung , Meinertz Naomi , Nyang’au Getrude , Gilligan Megan 
Published: January 2025

Abstract
Social jet lag is characterized by inconsistent sleep patterns between weekdays and weekends and arises from a misalignment between biological rhythms and social schedules, posing significant health risks. However, the sociodemographic determinants and health implications of social jet lag among middle-aged and older adults are unclear. In the current study, we examined cross-sectional associations between social jet lag, sociodemographic characteristics, and key mental, physical, and cognitive health outcomes. Among adults ages 50–83 (M = 68.22; SD = 7.85) in the 2018 wave of the Health and Retirement Study (N = 667; 62% women), approximately 49% of respondents experienced social jet lag. Bivariate correlations indicated that social jet lag was related to older age (r = –.35, p &lt;.001), Hispanic ethnicity (r =.13, p =.001), and current employment (r =.31, p &lt;.001), but not gender (p =.99) or education (p =.12). Results of multivariate regressions, controlling for the above sociodemographic determinants, indicated that greater social jet lag was associated with higher depressive symptoms (β = 0.14, p &lt;.001, R-squared =.10) and lower cognitive performance (β = –0.08, p =.04, R-squared =.24). Social jet lag was not significantly associated with body mass index (p =.36), number of chronic conditions (p =.59), or self-rated memory (p =.72). These findings point to the importance of a regular sleep schedule as a modifiable behavior that may promote better mental and cognitive health in midlife and beyond.
HEALTHY BRAIN AGING: OPPORTUNITIES AND CHALLENGES
Authors: Sixsmith Andrew 
Published: January 2025

Abstract
Dementia and cognitive decline are amongst the greatest challenges of modern times and have a major impact on individuals, families, and society. Although there are currently no effective treatments or cures for dementia-related conditions, there is huge scope for preventative measures to improve brain health as people grow older. By developing and implementing real-world solutions that address known modifiable risk-factors, the decline of cognitive health and the onset of dementia may be delayed or prevented. With the right combination of policies, services and changes in health-related behaviours, it may be possible to expand the healthspan of people, where most people can live healthier, active lives as they grow older. Our interdisciplinary symposium comprises four papers that examine the challenges and opportunities for brain health and healthy aging. Sylvain Moreno a discusses heterogeneity in neurocognitive aging, challenging the predominantly linear view of cognitive decline with age. Holland and colleagues draw on a Delphi consensus study to explore opportunities for developing Interventions for cognitive frailty, the potential to delay, prevent or reverse cognitive frailty, and how people with lived experience can contribute to clinical and research expertise, White, Sixsmith and Fang explore the role of community-based organisations in supporting healthy aging, focusing on practical strategies for mobilizing community assets and resources to promote healthy aging. Boot, Dilanchian and Kalantari examine the role of technologies to support healthy brain aging, particularly the potential of extended reality technologies to support older people with and without cognitive impairments.
THE ROLE OF COMMUNITY-BASED ORGANIZATIONS IN SUPPORTING HEALTHY AGING
Authors: White Rebecca , Sixsmith Andrew , Fang mei 
Published: January 2025

Abstract
Maintaining a healthy and balanced lifestyle is crucial for healthy aging and has a significant positive impact on brain health. Community-based organizations play an important role in many countries in promoting healthy lifestyles, particularly among those with the greatest social and economic need, through the provision of social, recreational, and informational programming. This presentation draws on research carried out in Vancouver, Canada, to understand the role of community-based organizations in enhancing the physical, social, and emotional well-being of older people. Using an institutional ethnographic case study approach guided by principles of community-based participatory research, the research focuses on the role of community-based organizations in enhancing older people’s well-being at multiple levels and contextualizes such organizations within a broader healthcare ecosystem. Results demonstrate the multi-faceted role community-based organizations play in supporting health and well-being among older people. The shift towards integrated healthcare models with a more holistic approach to health presents opportunities for community-based organizations to assume a more prominent role in empowering older people to self-manage their health and promote healthy lifestyles. Yet, such organizations face a multitude of challenges, particularly securing sustainable operational funding and widening their appeal to a changing demographic. The research highlights how community assets may be mobilized to better support the health and well-being of aging communities. More research is needed to understand how community-based organizations can better communicate their value and impact and enhance their capacity to respond effectively to emerging opportunities.
EXAMINING LGBT OLDER ADULT CHOSEN FAMILIES USING THE CONVOY MODEL OF SOCIAL RELATIONS
Authors: Breder Kelseanne , Bockting Walter 
Published: January 2025

Abstract
Sexual and gender minority (LGBT) older adults experience heightened levels of social discrimination and minority stress throughout their lives due to their minority identities. Older LGBT adults experienced unique external, systemic barriers to social acceptance, including bans on same-sex marriage, discrimination and negligence during the HIV epidemic, and police brutality during demonstrations such as the Stonewall Riots. LGBT older adults are also more likely to live alone and more likely to be estranged from their families of origin. Taken together, these discriminatory social experiences increase stress exposure and create a demand for an adaptive and protective social network to serve as a counterbalance to minority stress. Many LGBT older adults have developed “chosen families” or social networks composed of non-biological relatives who care for one another as if they are family. The LGBT chosen family is a resilience strategy that has not been examined thoroughly by a theoretical framework. The purpose of this paper is to apply the Convoy Model of Social Relations to examine the LGBT chosen family experience. The convoy metaphor succinctly captures the value of the LGBT chosen family, which functions not only to support members within the chosen family unit, but also to offset exposure to external threats and buffer internalized and externalized homophobia in a heteronormative society. The paper identifies points of convergence and departure between the model and LGBT chosen families and includes an analysis of the role of technology in LGBT older adult social networks. Modifications to the model are proposed.
WHAT ABOUT THE HANDS? EXAMINING OLDER ADULTS’ ATTITUDES, PERCEPTIONS, AND CLINICAL INTERACTIONS OF HAND FUNCTION
Authors: Cook Rachel Logue , Brown Susan 
Published: January 2025

Abstract
Age-related hand impairments are common yet receive little attention, thus often go undiagnosed until they have become severe. While it has been suggested that attitudes, perceptions, and clinical interactions play an important role in seeking care for physical limitations, the degree to which this extends to hand impairments is unknown. We developed an online survey which asked older adults (≥65) about their perceptions of hand function compared to other health areas, clinical interactions related to hand function, and barriers to accessing hand-related care. Five hundred and ninety-five older adults (mean age: 71.8 ± 5.5y) completed the survey. While 85% of respondents agreed that hand function is important for their daily life, only 40% expressed concern about losing function and only 2% ranked hand function as most important. Responses also indicated that hand function is rarely discussed (21%) or measured (52%) in the primary care setting. In addition, 34% of respondents said they have considered seeking care for a limitation but chose not to because they did not think their function was poor enough (33%), thought function would improve on its own (17%), or thought losing function is part of getting older (16%). Our results demonstrate that, although older adults understand the importance of hand function for completing activities, it is not prioritized by individuals or in the primary care setting. Such findings highlight a critical need to increase awareness of hand function in order to better identify impairments before they impede daily life and functional independence.