bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnosis and management of multiple Brown tumours in tertiary hyperparathyroidism in the Jaws
Authors: Loh Melissa , Feinberg Lee , Nixon Paul 
Published: July 2021

AbstractA 56‐year‐old male patient presented to an emergency dental service with multiple intra‐oral swellings. The intra‐oral swellings were seen radiographically as punched out radiolucencies in the upper right first molar region and the lower left second molar region.The patient had a complex medical history which included a diagnosis of chronic kidney disease (CKD), tertiary hyperparathyroidism and papillary thyroid cancer. Thyroid metastasis and Brown tumours were therefore considered as the differential diagnosis. The radiographic appearance favoured Brown tumours. The tumour in the upper right quadrant was excised with histology confirming Brown tumours. Surgical parathyroidectomy was subsequently performed. There was no further surgical intervention undertaken following the parathyroidectomy and over time, both intra‐oral swellings were found well healed with bony infiltration at both sites.
The Logical Analysis of Colour Statements in Wittgenstein’s Tractatus
Authors: Blue Bradford F. 
Published: July 2021

AbstractFollowing G. E. M. Anscombe, most commentators on Ludwig Wittgenstein’s Tractatus Logico‐philosophicus have held that §6.3751 rules out colour propositions as elementary propositions. However, a careful reading of some passages from The Big Typescript, MS 105 and MS 103, on the logical structure of colour and the logical analysis of colour statements, shows that the elementary propositions of the Tractatus include colour propositions. It follows that Anscombe’s interpretation of §6.3751 is mistaken.
Efficacy of Adjunctive Antimicrobial Photodynamic Therapy to Mechanical Debridement in the Treatment of Peri‐implantitis or Peri‐implant Mucositis in Smokers: A Systematic Review and Meta‐analysis
Authors: Shahmohammadi Rojin , Younespour Shima , Paknejad Mojgan , Chiniforush Nasim , Heidari Mohadeseh 
Published: July 2021

AbstractThis systematic review and meta‐analysis aimed to determine whether adjunctive use of antimicrobial photodynamic therapy (a‐PDT) in peri‐implant diseases improves clinical outcomes in smokers. An electronic search was performed in MEDLINE (through PubMed), Scopus, Cochrane Library, Embase, Web of Science and Google Scholar. The primary outcome measures were bleeding on probing (BOP) and pocket depth (PD). Plaque index (PI) was the secondary outcome. Four RCTs, (188 participants) comprised of 118 cigarette smokers, 38 E‐cig smokers and 32 water pipe smokers with follow‐up periods ranged from 6 weeks to 6 months were recruited. All trials applied diode laser in one session with wavelengths ranged from 660 to 670 nm. There was a significant difference between mechanical debridement (MD)+a‐PDT and MD alone groups in PD (WMD = −1.26 mm, 95% CI: −2.19 to −0.32, P = 0.01) and PI (WMD = −10.60%, 95% CI: −14.46 to −6.74, P < 0.001) at 3‐month follow‐up. However, a great amount of heterogeneity was observed (PD: χ2 = 199.19, I2 = 98%, P < 0.001 and PI: χ2 = 25.63, I2 = 84.4%, P < 0.001). Due to methodological heterogeneity and small number of studies, this systematic review was unable to reach conclusive evidence in regards of adjunctive a‐PDT efficacy in improving clinical parameters in smokers.
Accidental aspiration of removable dental prosthesis in a patient with Creutzfeldt‐Jacob disease
Authors: Baldo Mario Eduardo , Raffaele Regina Maria , Santanna Gabriel Umbelino , da Silva Santos Paulo Sérgio 
Published: July 2021

AbstractAccidents involving dental prostheses are unusual but relevant, which may result in complications in the upper respiratory airways and esophagus. A 47‐year‐old male patient with Creutzfeldt‐Jacob disease (CJD), completely dependent on care, was reported by his family to have a partial obstruction and intraoral bleeding after swallowing his upper Removable Partial Denture (RPD). After difficulties in the endoscopy procedure, a surgical approach by exploratory cervicotomy to remove the prosthetic device was conducted, without postoperative complications. Considering individual impairments and the patients’ advanced age, the removal of dental prostheses during sleep or for patients under intensive care is a preventive strategy to reduce comorbidities in patients with unstable health conditions.
Perceptions of person‐centred care in two large university hospitals: A cross‐sectional survey among healthcare professionals
Authors: Johnsen Anna Thit , Hølge‐Hazelton Bibi , Skovbakke Søren Jensen , Rottmann Nina , Thomsen Thora G. , Eskildsen Nanna B. , Pedersen Susanne S. 
Published: July 2021

AbstractBackgroundPatient‐centred care (PCC) including collaborative practices is the core component of modern health care. Despite this, it has proven difficult to implement.AimsTo examine (1) healthcare professionals’ (HCPs’) perception of whether they perceive a PCC culture, their attitudes towards involving patients in decisions and their experiences of barriers for PCC; and (2) variables that may contribute to explain differences in perceived person‐centred culture.MethodsA questionnaire survey of HCPs from 27 different departments from two university hospitals in Denmark. HCPs were eligible if they held a profession as physician, Registered Nurse, nurse assistant, physiotherapist, occupational therapist, dietician, midwife or psychologist and excluded if they reported not being involved in patient treatment and care. The questionnaire consisted of four items from the Context Assessment Index (CAI). The remaining items were purpose‐designed.ResultsIn total 1140 (24% response rate) HCPs completed the questionnaire and were included in the analyses. Most of the HCPs perceived a culture of PCC (e.g. 91% agreed or agreed to a high degree that patients were provided with opportunities to participate in decisions). Most HCPs also held positive attitudes towards involving patients in decisions. Time and prioritisation from the management were perceived as barriers for PCC, and many HCPs also believed that involving patients in decisions could be difficult for the patients. The HCPs who were least involved in treatment and care, and working in the acute setting or in surgery, were least likely to perceive a PCC culture. HCPs with the longest or shortest educations, and HCPs working primarily with outpatients or with planned inpatients, were most likely to perceive a person‐centred culture.ConclusionThe HCPs generally perceived a culture of PCC and held positive attitudes towards involving patients in decisions. To further promote PCC, time and prioritisation must be invested at an organisational level.
Information, reflection, and successful job search: A labor market policy experiment
Authors: Mühlböck Monika , Kalleitner Fabian , Steiber Nadia , Kittel Bernhard 
Published: July 2021

AbstractJobseekers, especially young people with little experience on the job market, face several challenges. They need to know which jobs are suited for them, where to find them, how to apply, and they need resilience in the face of repeated rejections. Previous research has shown that receiving information and reflecting on how to search for a job enhance self‐efficacy and search motivation, thereby reducing the duration of unemployment spells. Following up on these results, we conducted an experiment in cooperation with the Austrian Ministry of Social Affairs which combines an “information nudge” in the form of a short video‐clip with what we call “reflection nudge” in the form of an online survey. We find that a treatment combining reflection and information reduces job search duration of young unemployed people with a low level of formal education. Considering the low costs of the intervention, efficiency is very high.
Removing the Owner: Non‐Specified Possessor Marking in Arawak Languages*
Authors: Aikhenvald Alexandra Y. 
Published: July 2021

AbstractIn most Arawak languages, obligatorily possessed nouns are bound forms. They have to be accompanied by a possessor. If the possessor is unknown or irrelevant, the noun will take the non‐specified possessor suffix. A suffix of the same segmental form occurs in deverbal nominalizations with unspecified arguments, or as a nominalizer on verbs. We hypothesise that the non‐specified possessor suffix was originally a feature of obligatorily possessed nouns denoting body parts and a selection of culturally important items (including ‘house’) but not kinship terms. The common Arawak polysemy of a non‐specified possessor marker and a nominalizer, reconstructible for the proto‐language, appears to be cross‐linguistically rare.
Mitochondrial genomes within bark lice (Insecta: Psocodea: Psocomorpha) reveal novel gene rearrangements containing phylogenetic signal
Authors: Saenz Manchola Oscar Fernando , Virrueta Herrera Stephany , D'Alessio Lorenzo Mario , Yoshizawa Kazunori , García Aldrete Alfonso Neri , Johnson Kevin P. 
Published: July 2021

ABSTRACTPsocodea (booklice and parasitic lice) is an order of insects containing species with extensive mitochondrial genome rearrangements, particularly within the suborder Troctomorpha, in which some species possess an extremely fragmented mitochondrial genome with several small minichromosomes. In the remaining suborders of Psocodea, there are groups with the ancestral pancrustacean arrangement, quite extensive rearrangements (e.g. Trogiomorpha), or in which the small number of species analysed to date have rearrangements of only a few protein‐coding genes and/or tRNAs (e.g. Psocomorpha). Despite the apparent high rate of rearrangements in the order as a whole, a small number of complete mitochondrial genomes are available, especially for suborder Psocomorpha, the largest free‐living suborder. To understand the evolution of the gene arrangement of the mitochondrial genome within Psocomorpha and its phylogenetic implications, we assembled and analysed the mitochondrial genomes of 33 species of bark lice belonging to nine families in two infraorders. Within the infraorder Homilopsocidea, four families were analysed, mainly from Lachesillidae (which included 22 species of this family). Within the infraorder Caeciliusetae, seven species representing five families were analysed. Mitochondrial gene rearrangements were identified in seven of the nine families. Some of these rearrangements were unique to a single species, while some contained phylogenetic signal, being shared by related species. These rearrangements typically corresponded to transpositions and inversions of tRNAs, possibly caused by tandem duplication–random loss (TDRL) and/or recombination events. Phylogenetic analyses of mitochondrial gene sequences provided phylogenetic resolution for several branches of the tree, including monophyly of Lachesillinae. The genus Hemicaecilius Enderlein was found to be embedded within the genus Lachesilla Westwood, rending the latter paraphyletic. Monophyly was also never recovered for Lachesillidae and Elipsocidae as currently defined. However, instability was observed for some higher level relationships within Psocomorpha, including the relationships among the major clades of Lachesillidae.
Clinical findings associated with blunt ocular trauma in horses: a retrospective analysis
Authors: Charnock Lauren N. , Keys Deborah A. , McMullen Richard J. 
Published: July 2021

AbstractObjectiveIdentify ocular findings associated with blunt ocular trauma to aid in differentiation from other equine ocular diseases.Study designRetrospective case‐control study.MethodsMedical records of horses at the Equine Clinic Munich‐Riem, Munich, Germany and Auburn University, College of Veterinary Medicine were reviewed. Age, sex, breed, laterality, and clinical findings on ophthalmic examination, as well as an observed (confirmed) or unobserved (suspected) history of trauma, were recorded. Statistical analysis was performed to identify any correlation between clinical signs and blunt ocular trauma. Fifty‐nine clinical signs were evaluated, and their association with blunt ocular trauma and non‐traumatic uveitis was determined. The frequency of clinical signs associated with non‐traumatic uveitis was also reported.ResultsFifty‐five eyes affected with blunt trauma were included. The comparison group consisted of 233 eyes (168 horses) diagnosed with non‐traumatic uveitis. The most frequent ocular findings after BOT included cataract (36/55, 65.5%), corneal edema (26/55, 47.2%), decreased intraocular pressure (23/55, 41.8%), aqueous flare (19/55, 34.5%), lens subluxation, luxation, or lens loss (18/55, 32.7%), fibrin in the anterior chamber (18/55, 32.7%), hyphema (16/55, 29.1%), peripapillary depigmentation (“butterfly lesion”) (16/55, 29.1%), conjunctival hyperemia (16/55, 29.1%), corneal fibrosis (15/55, 27.3%), corpora nigra avulsion (14/55, 25.5%), blepharospasm (13/55, 23.6%), and iridodialysis (11/55, 20.0%).ConclusionsThe characteristic pattern of ocular signs associated with blunt ocular trauma may assist in differentiation from other types of uveitis and may improve interpretation of ocular lesions identified during pre‐purchase examinations. This study also represents the first peer‐reviewed documented and photographed cases of iridodialysis in the horse.
Hematoma subdural crónico. Una actualización y revisión
Authors: Rojas Quiñones Maria Ximena , Gómez Vega Juan Carlos 
Published: July 2021

El hematoma subdural crónico es una de las entidades más frecuentes en la práctica médica general y neuroquirúrgica, por lo cual, su diagnóstico y tratamiento mejora el pronóstico de los pacientes. El factor más frecuente implicado para el desarrollo es el trauma, sin embargo, se conocen otros factores como la antigcoagulación, la fragilidad o dependencia funcional total, las comorbilidades, la atrofia cerebral, entre otros. El tratamiento del hematoma subdural crónico es quirúrgico, cuando este esta contraindicado, es recurrente o no esta indicada la intervención quirurgica, se plantean otros tratamientos como el manejo médico y la embolización de la arteria meníngea media, obteniendo gran auje en los últimos años este último. El objetivo del presente articulo es describir los conceptos generales del hematoma subdural crónico, énfasis en el manejo médico actual y la terapia endovascular
The Effects of Acute and Long-Term Whole-Body Vibration Training on the Postural Control During Cognitive Task in Patients With Chronic Ankle Instability
Authors: Tohidast Seyed Abolfazl , Bagheri Rasool , Safavi-Farokhi Ziaeddin , Khaleghi Hashemian Mohammad , Delkhosh Cyrus Taghizadeh 
Published: July 2021

Context: Chronic ankle instability (CAI) is a common problem associated with impaired postural stability. Whole-body vibration (WBV) has been developed to improve muscle function and reportedly improves postural stability. The aim of this study was to evaluate the effect of 12 sessions of WBV on postural control during standing postural task in participants with CAI. Design: A controlled clinical trial study. Methods: Sixteen participants with CAI and 16 healthy participants aged between 20 and 40 years included in this study. They received WBV (30-Hz frequency, 3 series of four 45-s exercises with a 45-s rest) for a total of 12 sessions, 2 session per week for 6 weeks. Postural control was assessed by center of pressure (COP) parameters, including mean and SD in the anterior–posterior and medial–lateral displacement during single-leg standing. Assessments were done before and immediately after the first session and after the 12th session of WBV, with opened and closed eyes associated with easy and difficult cognitive tasks. Results: The results showed that the SD of COP displacement in the x-axis was significant in eyes opened and SD of COP displacement in the x- and y-axes were significant between groups in the eyes-opened, and eyes-closed conditions (P < .05). Analysis of variance indicated that the effect of WBV training was significant for the mean of COP displacement in the y-axis. Post hoc indicated that the effect of 12 sessions of WBV on the mean of COP displacement was significant in the CAI group (P < .05). However, the acute effect of WBV was not significant on the COP displacement in all axes (P > .05). Conclusion: Higher postural sway associated with postural cognitive interactions might be considered in the rehabilitation of CAI. Twelve sessions of WBV might induce some improvement in postural control with the method of WBV used in this study.
Vein topology, structures, and distribution during the prograde formation of an Archean gold stockwork
Authors: Turlin François , De Souza Stéphane , Jébrak Michel , Groulier Pierre-Arthur , Turcotte Jordi 
Published: July 2021

Abstract
The Archean Cheechoo stockwork gold deposit is hosted by a felsic intrusion of tonalitic-granodioritic composition and crosscutting pegmatite dikes in the Eeyou Istchee James Bay area of Quebec, Canada (Archean Superior craton). The evolution of the stockwork is characterized herein using field relationships, vein density, and connectivity measurements on drill core and outcrop zones. The statistical distribution of gold is used to highlight mechanisms of stockwork emplacement and gold mineralization and remobilization.
Two statistical populations of gold concentration are present. Population A is represented by gold grades below 1 g/t with a lognormal cumulative frequency. It is widespread in the hydrothermally altered (albite and quartz) and mineralized facies of the pluton. It is controlled by the development of quartz-feldspar-diopside veins as shown by the similar lognormal distribution of grades and vein density and by the correspondence of grades with network connectivity. Diopside and actinolite porphyroblasts in deformed veins within sodic and calcsilicate alteration zones are evidence for auriferous vein emplacement prior to the amphibolite facies peak of metamorphism.
Population B (&gt;1 g/t) is erratic and exhibits a strong nugget effect. It is present throughout the mineralized portion of the pluton and in pegmatites. This population is interpreted as the result of gold remobilization during prograde metamorphism and pegmatite emplacement following the metamorphic peak. The pegmatites are interpreted to have scavenged gold emplaced prior to peak metamorphism.
These results show the isotropic behavior of the investigated stockwork during regional deformation and its development during the early stages of regional prograde metamorphism.
Magmatism in the Siang window of the Eastern Himalayan Syntaxis, NE India: a vestige of Kerguelen mantle plume activity
Authors: Singh Athokpam Krishnakanta , Oinam Govind , Chung Sun-Lin , Bikramaditya R. K. , Lee Hao-Yang , Joshi Mallickarjun 
Published: July 2021

Abstract

We report new U–Pb zircon ages for mafic plutonic (gabbro) and volcanic (andesite) rocks, along with the whole-rock chemistry of a mafic–felsic suite of volcanic rocks from the Siang window of the Eastern Himalayan Syntaxis, NE India. Field relationships, and mineralogical and geochemical characteristics, of the studied mafic–intermediate–felsic rocks suggest their co-magmatic linkage that was generated in an extensional tectonic environment. Incompatible trace elements and low concentrations of large ion lithophile elements (LILEs) and REE behaviour reflect both the enriched nature of the mafic rocks and the limited influence of crustal contamination in their genesis. Partial melting and fractional crystallization processes have played a major role during the genesis of these felsic volcanics from the parental mafic magma. The laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U–Pb ages suggest that the mafic plutonic rock was emplaced at
c.
121.18 ± 1 Ma and intermediate volcanic rock was emplaced at
c.
135.48 ± 0.50 Ma during the Early Cretaceous period. The new ages are consistent with earlier reported zircon U–Pb ages (133.0 ± 1.9–130.7 ± 1.8 Ma) of felsic volcanic rocks from the present study area. Our new field observations, and mineralogical and geochemical characteristics, in conjunction with the U–Pb isotopic database suggest that the major magmatic event in the core of the Siang window of the Eastern Himalaya is coeval with the Rajmahal–Sylhet–Mikir–Shillong flood basalts of eastern and northeastern India, and the Comei–Bunbury Large Igneous Province of southeastern Tibet and SW Australia. These events are related to the break-up of eastern Gondwana and outbreak of the Kerguelen plume.
Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor
Authors: Wang Chu-An , Li Chien-Feng , Huang Rho-Chi , Li Yo-Hua , Liou Jing-Ping , Tsai Shaw-Jenq 
Published: July 2021

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by early dissemination and poor drug response. Therefore, it is an unmet medical need to develop new strategies for treatment. As aberrant activation of ERK due to KRAS activating mutation is a driving force for PDAC, a brake system that can terminate ERK signaling represents an ideal druggable target. Herein, we demonstrate that forced expression of dual specificity phosphatase-2 (DUSP2), a specific ERK phosphatase, abrogated tumor formation and loss of Dusp2 facilitated Kras-driven PDAC progression. We report that a selective HDAC1/2 inhibitor (B390) has multifaceted therapeutic potential in PDAC by restoring the expression and function of DUSP2. In vitro study showed that treatment with B390 inhibited growth and migration abilities of PDAC cells, decreased extracellular vesicle-associated VEGF-C expression, and suppressed lymphatic endothelial cell proliferation. In vivo, B390 not only suppressed tumor growth by increasing tumor cell death, it also inhibited lymphangiogenesis and lymphovascular invasion. Taken together, our data demonstrate that B390 was able to alleviate loss of DUSP2-mediated pathologic processes, which provides the proof-of-concept evidence to demonstrate the potential of using selective HDAC1/2 inhibitors in PDAC treatment and suggests reinstating DUSP2 expression may be a strategy to subside PDAC progression.