bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Artificial Intelligence With Natural Language Processing to Combine Electronic Health Record’s Structured and Free Text Data to Identify Nonvalvular Atrial Fibrillation to Decrease Strokes and Death: Evaluation and Case-Control Study (Preprint)
Authors: Elkin Peter L , Mullin Sarah , Mardekian Jack , Crowner Christopher , Sakilay Sylvester , Sinha Shyamashree , Brady Gary , Wright Marcia , Nolen Kimberly , Trainer JoAnn , Koppel Ross , Schlegel Daniel , Kaushik Sashank , Zhao Jane , Song Buer , Anand Edwin 
Published: March 2021

BACKGROUND

Nonvalvular atrial fibrillation (NVAF) affects almost 6 million Americans and is a major contributor to stroke but is significantly undiagnosed and undertreated despite explicit guidelines for oral anticoagulation.

OBJECTIVE

The aim of this study is to investigate whether the use of semisupervised natural language processing (NLP) of electronic health record’s (EHR) free-text information combined with structured EHR data improves NVAF discovery and treatment and perhaps offers a method to prevent thousands of deaths and save billions of dollars.

METHODS

We abstracted 96,681 participants from the University of Buffalo faculty practice’s EHR. NLP was used to index the notes and compare the ability to identify NVAF, congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65 to 74 years, sex category (CHA<sub>2</sub>DS<sub>2</sub>-VASc), and Hypertension, Abnormal liver/renal function, Stroke history, Bleeding history or predisposition, Labile INR, Elderly, Drug/alcohol usage (HAS-BLED) scores using unstructured data (International Classification of Diseases codes) versus structured and unstructured data from clinical notes. In addition, we analyzed data from 63,296,120 participants in the Optum and Truven databases to determine the NVAF frequency, rates of CHA<sub>2</sub>DS<sub>2</sub>‑VASc ≥2, and no contraindications to oral anticoagulants, rates of stroke and death in the untreated population, and first year’s costs after stroke.

RESULTS

The structured-plus-unstructured method would have identified 3,976,056 additional true NVAF cases (<i>P</i>&lt;.001) and improved sensitivity for CHA<sub>2</sub>DS<sub>2</sub>-VASc and HAS-BLED scores compared with the structured data alone (<i>P</i>=.002 and <i>P</i>&lt;.001, respectively), causing a 32.1% improvement. For the United States, this method would prevent an estimated 176,537 strokes, save 10,575 lives, and save &gt;US $13.5 billion.

CONCLUSIONS

Artificial intelligence–informed bio-surveillance combining NLP of free-text information with structured EHR data improves data completeness, prevents thousands of strokes, and saves lives and funds. This method is applicable to many disorders with profound public health consequences.
Simultaneous Estimation and Validation of Artemether and Lumefantrine by UV Spectrophotometry in Tablet
Authors: Mishra Megha , Mundada Anand 
Published: March 2021

A UV spectrophotometric method has been developed for the simultaneous determination of Artemether and Lumefantrine. The spectroscopic method for estimation of Artemether and Lumefantrine employed Area under curve method for analysis using Ethanol as solvent. Artemether has absorbance maxima 253.2 nm and Lumefantrine has absorbance maxima 235.2 nm and both these drugs obey Beer's law in concentration range of 4.24 -67.84 μg/ml for Artemether and 4.68 -28.08 μg/ml for Lumefantrine. The recovery studies ascertained the accuracy of the purposed method and the results were validated as per ICH guidelines. The results were found satisfactory and reproducible. The method was applied successfully for the estimation of Artemether and Lumefantrine in tablet dosage form without the interference of common excipients.
Keywords: Artemether, Lumefantrine; Area under curve; Simultaneous; Estimation
Cost Effective, Efficient and Stability indicating Method Development & Validation for determination of related substances for Levonorgestrel & Ethinyl Estradiol Tablets
Authors: Dash Abhiram , Jain Neelu , Pandey Harish 
Published: March 2021

The objective of this research was to develop and validate a simple, specific and accurate reverse phase of high performance of liquid chromatographic method for the determination of levonorgestrel (LVG) and ethinylestradiol (EE) in tablets. The chromatographic system included column Sun Fire ODS (150 mm × 4.6 mm i.d., particle size at 5 μm), mobile phase consisting of acetonitrile: methanol: aquabidest (60:15:25) with the flow rate of 1 mL/minute and effluents monitored at 230 nm. The validation of RP HPLC method for the simultaneous determination of LVG and EE was determined by accuracy, precision, linearity, and limit of detection (LOD) as well as the limit of quantitation (LOQ) parameters. The linearity range of both drugs was 1-70 µg/mL and 2-14 µg/mL for LVG and EE, respectively. The recoveries of LVG and EE were at 101.78% and 102.44% with the coefficients of variation of 0.94% and 1.92%, successively. The LOD of LVG and EE value were of 0.84 µg/mL and 0.03 µg/mL, and LOQ value were of 2.79 and 0.09µg/mL, respectively.
Keywords: Levonorgestrel (LVG), Ethinylestradiol, Method Validation, Method Validation, HPLC
Medicinal Plants from Vettangudi Water Bird Sanctuary in Sivagangai District of Tamil Nadu, Southern India
Authors: Shanmugam S , Muthupandi C P , Eswaran V M , Rajendran K 
Published: March 2021

Most of the people depending on traditional medicine to meet their primary healthcare needs. Documenting the indigenous knowledge through ethnobotanical studies is important for the conservation of biological resources as well as their sustainable utilization. It is also necessary to collect the information about the knowledge of traditional medicines before it is permanently lost. Having all these facts in mind, the present study was carried out to document the plants used as medicine by the people inhabiting around the Vettangudi Water Bird Sanctuary of Sivagangai district in Tamil Nadu, India. The field survey was conducted in two villages situated near to Vettangudi Water Bird Sanctuary. The medicinal uses of 40 angiospermic plant species belonging to 36 genera of 24 families for various diseases and ailments were recorded by this study. The people inhabiting in the study area used 45 herbal therapies prepared from 40 plants to treat 27 different illnesses. Regarding the plant parts used, leaf was the mostly used plant part (51.16%) and extract was found as mostly followed mode (42.28%) to treat a particular disease. Attention should be made on proper exploitation and utilization of these medicinally important plant species.
Keywords: Medicinal plants, Vettangudi Water Bird Sanctuary, Sivagangai district, Tamil Nadu.
Formulation Development and Evaluation of New Albendazole Tablets with Integrated Quality by Design (QbD) Approach
Authors: Sitre Dnyaneshwar G , Kamble Ravindra K. 
Published: March 2021

Hydatid disease occurs in most areas of the world and currently affects about one million people. Albendazole is an orally administered broad spectrum anthelmintic drug approved by US FDA in 1996. Literature review suggests Albendazole is low solubility compound and most of the studies were performed to improve the solubility with traditional approach of product development. The present study was aimed to apply Design of Experiments (DoE) in the development and optimization of drug release from new Albendazole tablets using three factor two level (23) full factorial designs with integrated Quality be Design (QbD) approach. New Albendazole tablets were formulated using micronized grade of the Albendazole active and excipients were selected inline with market reference product. Quality target product profile (QTPP) and Critical quality attributes (CQAs) were designed. Risk assessment was used to identify the Formulation variables impacting CQA dissolution. The amount of Formulation variables were optimized on the basis of drug release profiles at 15 minutes and 30 minutes of different formulation batches manufactured based on 23 full factorial design. Tablets were prepared by wet granulation technique and evaluated for various physicochemical parameters and in vitro drug release. Formulation trials dissolution results at 15 minutes and 30 minutes were evaluated to derive the concentration of Formulation variables which will achieve the release of more than 80%. Analysis of variance (ANOVA) analysis, Pareto chart and Contour plot were used to predict the values of formulation variables and their effect on dissolution. Updated risk assessment of the Formulation Variables was performed and justification was provided for reduction of risk from medium to low level. Optimized formulation from DOE had comparable dissolution profile with market reference tablet. Stability studies of new Albendazole tablets 200 mg were conducted at ICH accelerated conditions and found to be stable. Thus studies revealed that full factorial experimental design could efficiently be applied for optimization of formulation variables affecting drug release. New Albendazole tablets 200 mg successfully formulated with application of the integrated quality by design (QbD) and design of experiment (DOE) approach and thereby achieved comparable release profile with market reference product.
A Novel Composite Biomarker Panel For Detection Of Early Stage Non-small Cell Lung Cancer
Authors: Bédard Eric L.R. , Abraham Aswin G. , Joy Anil A. , Ghosh Sunita , Wang Xiaoyu , Lim Andrew , Shao Dongyu , Loebenberg Raimar , Roa Wilson H. 
Published: March 2021

Purpose: To investigate a novel composite methodology of using targeted serum microRNAs (micro ribonucleic acid; miRNA) and urine metabolites for the accurate detection of early stage non-small cell lung cancer
(NSCLC).

Methods: Consecutively consenting NSCLC patients and matched control subjects were recruited to provide samples of serum for miRNA and/or urine for metabolite analyses. Serum miRNA levels were measured using quantitative real-time reverse-transcription with exogenous control, and the comparative delta cycle threshold (&#9651CT) method was used to calculate relative miRNA expression of two targeted miRNAs (miR-21 and miR-223). The concentrations of six targeted urinary metabolites in patients and healthy controls were measured using proton nuclear magnetic resonance (1H NMR) spectroscopy. A composite methodology of using the 35 accruals with both serum and urine biomarkers was then established with binary logistic regression, receiver operating characteristic (ROC) models with or without artificial intelligence (AI).

Results: The ROC analysis of miRNA expression yielded a sensitivity of 96.4% and a specificity of 88.2% for the detection of early stage NSCLC, with area under the curve (AUC) = 0.91 (CI 95%: 0.80-1.0). Relative urinary concentrations of 4-methoxyphenylacetic acid (4MPLA) were significantly different between NSCLC and healthy control (p=0.008). The ROC analysis of 4MPLA yielded a sensitivity of 82.1% and a specificity of 88.2%, with AUC = 0.85. The composite process combining miRNA and metabolite expression demonstrated a sensitivity and specificity of nearly 100% and AUC=1.

Conclusions: A highly specific, sensitive and non-invasive detection method for NSCLC was developed. Pending validation, this can potentially improve the early detection and, hence, the treatment and survival outcomes of patients.
Political Involvement among Youth in Malaysia: Lessons Learnt
Authors: Ahmad Zalinah , Mohd Zain Zawiyah 
Published: March 2021

Youth are asset for the country and their ideas may provide significant contribution towards the country development process. They are the driving force towards the progress of the country and their contributions are undeniable in providing new ideas. Other than as the human capitals provided for the workforce, youth are also backbone of the country. Youth involvement in politics happen throughout the world and Malaysia has no exception. Youth have voice out their concern on the government’s policies and actions towards developing process by using available platform such as social media other than joining political parties or any association specifically for youth. The opportunities should be given to this group since country will lose creative, dynamic and innovative ideas from this group, known as Generation Y. The tagline like young leaders have create phenomena to give them opportunities to be leader at every level of government (community, state as well as country). This article will discuss the political involvement based on the survey among students in Universiti Utara Malaysia. Findings showed that internet (social media) has attracted the respondents to know more about politics. Their lower involvement in political parties’ activities are quite contradictory in which their willingness to vote and encourage others to vote during the election process in Malaysia. This paper will highlight the importance of social media as a platform for gaining youth involvement in political scenario in Malaysia.
A study of the prevalence of metabolic syndrome in newly detected Diabetes Mellitus Type 2
Authors: Thorat S. T  , Vivek Redkar  , Amit C. Botre  , Vaibhav Agarwal  , Nitin B. Jadhav  
Published: March 2021

The metabolic disorder is depicted as bunches of irregularities, including stomach corpulence, insulin opposition, hypertension, hyperglycaemia, expanded fatty oils, and diminished high-thickness lipoprotein cholesterol. The study was aimed to assess the Pervasiveness of Metabolic disorder in recently identified sort 2 Diabetes mellitus Among 100 newly detected type 2 DM patients, 44.18% of male and 55.82% of female had metabolic syndrome. The maximum number of patients were in the age of 30-49 years. Most of the patients had a history of DM of 4-6 months (54%). Majority 60 patients (69.76%) and IDF criteria predicting MS in 40(46.51%) patients which is least compared to others. Modified WHO and NCEP ATP III criteria's were predicting MS 55(63.95%), 48(55.81%) respectively. Raised serum TG for men (45.3%) and diminished HDL for ladies (45.3%) were most grounded single indicator successfully showing the presence of MS in recently identified type 2 DM patients. Significant WC was seen in 51.2% of patients, and 46.5% of patients had significant waist/hip ratio. CONCLUSION- Raised serum TG for men and lessened HDL for women were most grounded single pointers, satisfactorily exhibiting the presence of MS in as of late distinguished sort 2 DM patients.
IMPLIKASI STRUKTUR MODAL, KEPEMILIKAN MANAJERIAL, DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN PADA SUB SEKTOR PROPERTI DAN REAL ESTATE YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE 2014-2019
Authors: Fatmawati Oktarias , Wiyono Gendro , Cahya Agus Dwi 
Published: March 2021

The purpose of this study was to determine the implications of the variable capital structure, managerial ownership, and dividend policy on firm value in the property and real estate sub sector listed on the Indonesia Stock Exchange (IDX) for the 2014-2019 period. The sample in this research is property and real estate companies listed on the Indonesia Stock Exchange (IDX) for the 2014-2019 period with a total of 6 companies obtained using the purposive sampling method. The data analysis technique uses multiple linear regression analysis which is supported by classical assumption tests such as normality test, multicollinearity test, heteroscedasticity test, and autocorrelation test. The results of this study indicate that capital structure has a positive and significant effect on firm value, managerial ownership has a positive and significant effect on firm value, while dividend policy has no significant effect on firm value. Simultaneously, capital structure, managerial ownership, and dividend policy have a positive and significant effect on firm value.
Keywords: Capital Structure, Managerial Ownership, Dividend Policy dan Firm Value
Analytical & Experimental Analysis of Lightning Stokes Performance & Protection by MOV Based Simulation Model: A 33 KV Transmission Line Case Study
Authors: Mehmood Arsal , Hassan Huzaifa , Baig Faraz Ahmed , Shaikh Suhail Ahmed 
Published: March 2021

Researchers are working on techniques to mitigate failure rates as low as possible to avoid potential harm, sustain high power efficiency for this a considerable number of estimation studies were already performed and several designs of methodologies were being suggested. The transmission line performs the role of the arteries which maintain the process of transporting electricity in the transmission line. That is why it is important to maintain and manage the costs of these tracks. Surge arrestor and shield wire application are often techniques chosen for defensive strategy in a very technique. By pushing travelling waves towards the electrical equipment mounted on the transmission line, the effects of lightning stoke on the transmission line may cause severe damage to the electrical equipment. In this review, this research study provides a review-based overview of the mechanism of occurrence of lightning along with its impact on the transmission line and the defence methods used to prevent such effects. A MATLAB / SIMULINK 2020a simulation modeling-based analysis for the incidence of lightning on the 33 kV transmission line system is observed in this regard, and a Metal-Oxide surge arrestor-based lightning fault clearance safety scheme is also suggested and discussed.
Horizontal and Vertical Analysis of SAMSUNG Enterprise for the Years 2015-2016 and 2017-2018
Authors: Shala Blerona , Prebreza Abetare , Ramosaj Berim 
Published: March 2021

The paper reflects our study about the horizontal and vertical analysis of financial statements. In this small volume we have tried to give meaningful, close and clear explanations. We have tried to methodologically elaborate the task in a gradual way. The paper is worked in several parts for the purpose of easier understanding.
The paper presents the original data of the financial statements, which elaborates the horizontal and vertical analysis of the balance sheet and the SAP for the years 2015-2015 and 2017-2018, in the next part is presented our commentary on the findings of the analysis for the above years. For this paper, SPSS software was used as a tool to interpret the results obtained from the questionnaire that was formulated for this paper.
PENGARUH KUALITAS WEBSITE TERHADAP KEPUTUSAN PEMBELIAN LAYANAN PEMESANAN KAMAR HOTEL PADA SITUS TRAVELOKA
Authors: Megawati Yenli 
Published: March 2021

<p align="center"><strong>ABSTRAK</strong></p><p><strong> </strong></p><p>Perkembangan teknologi termasuk internet semakin hari semakin pesat dan berdampak pada perubahan pola bisnis dan juga perilaku konsumen khususnya perilaku konsumen online. Salah satu bisnis yang semakin marak saat ini adalah layanan pemesanan kamar hotel melalui berbagai situs online. Cukup banyak perusahaan online yang menawarkan jasa ini dengan berbagai penawaran dan inovasi masing-masing. Dengan berbagai penawaran ini, konsumen juga memiliki banyak pilihan sebelum memutuskan untuk melakukan pembelian. Untuk itu, penelitian ini berupaya mencari tahu mengenai faktor-faktor yang diperkirakan memiliki pengaruh atas keputusan pembelian yang diambil konsumen. Faktor-faktor yang diteliti pada penelitian ini antara lain kualitas penggunaan, kualitas interaksi, dan kualitas informasi. Penelitian ini mengambil studi kasus pada situs Traveloka yang merupakan salah satu situs yang paling sering diingat dan dikunjungi oleh konsumen. Pengumpulan data pada penelitian ini dilakukan dengan survey menggunakan kuesioner. Responden dari survey ini adalah konsumen yang pernah melakukan transaksi pembelian layanan pemesanan kamar hotel secara online di Traveloka. Jumlah sampel pada penelitian ini adalah sebanyak 50 responden. Data yang dikumpulkan dianalisis menggunakan analisis regresi menggunakan SPSS setelah terlebih dahulu diuji untuk validitas, reliabilitas serta uji asumsi klasik.</p><p><strong> </strong></p><p><strong>Kata kunci: </strong>Kualitas Penggunaan, Kualitas Interaksi, Kualitas Informasi, Kualitas Website, Keputusan Pembelian, Online<em></em></p>
Evaluación de desinfectantes para uso en el entorno farmacéutico
Authors: Fajardo Cedeño Leobel 
Published: March 2021

Introducción: Los desinfectantes son utilizados en las empresas farmacéuticas para garantizar la disminución o eliminación de los microorganismos que puedan estar presentes en las líneas de producción, equipamiento, personal o ambiente. Aunque el fabricante garantiza la efectividad de los mismos es necesario probarlos en el entorno farmacéutico donde se van a utilizar.
Método: se evaluaron tres desinfectantes, NDP-Surfaplus en concentración del 70%, NDP-Surfaclin en concentración del 2% y 0,5% y Tristel Jet gel activado a la concentración 0,12%. Se practicaron hisopados antes y después de la aplicación del desinfectante a tramos de superficies de paredes, pisos, mesetas de mármol y fregaderos de acero inoxidable, De cada superficie se escogieron los tramos que presentaban mayor dificultad para realizar los procesos de limpieza y desinfección. El método de conteo utilizado fue el de placa vertida.
Resultados: se demostró que los desinfectantes cumplieron con la reducción del 90% de la población microbiana inicial, exceptuando la concentración del 0,5% del desinfectante NDP-Surfaclin. Se aisló mayor número de microorganismos en las superficies que tenían tendencia a formar poros debido a la erosión de los procesos de limpieza y desinfección, así mismo se demostró que los desinfectantes tenían una mejor actividad en las superficies de acero inoxidable.
Conclusiones: se demostró la efectividad de los desinfectantes en el entorno farmacéutico de la línea de formulación aprobándose su uso para los procesos de limpieza y desinfección. El desinfectante de mejor actividad fue el NDP-Surfaplus a la concentración del 70%.
Penyampaian Informasi Pekerjaan Bagi Fresh Graduate Melalui Realistic Job Previews
Authors: Wijaya Adi , Sinambela Frikson C 
Published: March 2021

This field experiment review aim was to examine four hypotheses of Realistic Job Previews (RJPs) on 20 fresh graduates respondents. Declarative knowledge, RJPs measurement scale, and interview was used as method of data gathering. The data results by using Mann-Whitney U Test showed that there is no significant relation (p = 0,462) among met expectation variable (p = 0,333), coping strategy (p = 0,462), honesty and integrity perception (p = 0,822) and likelihood to stay (p = 0,469). The research implications are if there is similarity between general expectation and reality of a job, and low possibility for the respondents to reject the job offer, then RJPs won’t give any positive and significant effect in pre-hire process.
Gambaran Subjective Well Being pada Individu Ditinjau dari Intensitas Bermain Game Online
Authors: Purwaningtyas Fifin Dwi 
Published: March 2021

Intensitasnya bermain game online di Indonesia membuat pemainnya menjadi kecanduan game online dan mengabaikan serta melupakan kegiatannya sehari-hari guna dapat bermain game secara terus menerus. Peneliti mendapatkan subjek sebanyak 81 orang, dari usia 15 sampai 40 tahun dan yang suka bermain game online, metode penelitiannya kuantitatif dengan menggunakan teknik sampling, Hasil penelitiannya nilai signifikansi Sig.(2-tailed) antara Subjective Well Being dengan intensitas bermain game online adalah sebesar 0,000; sehingga nilai tersebut lebih besar dari 0,05 dan nilai r hitungnya sebesar 0,705 lebih besar dari r tabel yaitu 0,215. Hal ini berarti bahwa terdapat hubungan antara Subjective well being pada Individu ditinjau dari Intensitas Bermain Game online. Kesimpulannya terdapat hubungan positif antara subjective well being dengan intensitas bermain game online menunjukan bahwa semakin tinggi intensitas bermain game online maka akan semakin tinggi subjective Well Beingnya, hal ini diharapkan untuk subjek bisa mengurangi intensitas bermainnya agar tidak merugikan diri sendiri dan bisa juga menghabiskan waktu dengan berinteraksi dengan teman, dan keluarga atau melakukan kegiatan yang positif.