bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions of clomazone plus pendimethalin mixed with propanil in rice
Authors: Osterholt Matthew J. , Webster Eric P. , McKnight Benjamin M. , Blouin David C. 
Published: January 2021

AbstractA study was conducted at the Louisiana State University Agricultural Center’s H. Rouse Caffey Rice Research Station in 2017 and 2018 to evaluate the interaction between a prepackage mixture of clomazone plus pendimethalin applied at 0, 760, 1,145, or 1,540 g ai ha−1 mixed with propanil at 0, 1,120, 2,240, or 4,485 g ai ha−1. A synergistic response occurred when barnyardgrass was treated with all rates of clomazone plus pendimethalin mixed with either rate of propanil evaluated at 56 d after treatment (DAT). Unlike barnyardgrass, an antagonistic response occurred in yellow nutsedge used as a control when treated with 760 and 1,540 g ha−1 of clomazone plus pendimethalin mixed with 1,120 or 22,40 g ha−1 of propanil at 28 DAT; however, 1,145 g ha−1 of clomazone plus pendimethalin mixed with 4,485 g ha−1 of propanil resulted in a neutral interaction. At 28 DAT, rice flatsedge treated with all herbicide mixtures resulted in neutral interactions. The synergism of clomazone plus pendimethalin applied at 1,540 g ha−1 mixed with propanil applied at 2,240 or 4,485 g ha−1 to control barnyardgrass resulted in an increased rough rice yield compared with 760 or 1,145 g ha−1 of clomazone plus pendimethalin mixed with propanil applied at 1,120 or 2,240 g ha−1. These results indicate that if barnyardgrass and rice flatsedge are present in a rice field the prepackage mixture of clomazone plus pendimethalin mixed with propanil can be an option for growers. However, if yellow nutsedge infest the area other herbicides may be needed.
Components of Himalayan River Flows in a Changing Climate
Authors: Chandel Vikram S. , Ghosh Subimal 
Published: January 2021

AbstractAssessment of the response of the Himalayan river flows to climate change is complex due to multiple contributors: rainfall, snowmelt, and glacier‐melt. The number of studies is limited in this direction due to lack of data availability as well as non‐availability of models considering all the above‐mentioned components. As for example, the state‐of‐the‐art variable infiltration capacity (VIC) model does not account for the glacier melt. Here we integrate a glacier‐melt model with VIC and validate the model output with observed streamflow in five river basins in the Himalayas, at daily scale. Our model simulates the streamflow with Nash‐Sutcliffe estimates greater than 0.65 in all basins. The sensitivity analysis shows that the contribution from snowmelt decreases substantially in all the five basins with highest decrease of 36% in Dudh Kosi (DK), in a warm and dry scenario. The glacier‐melt increases (15%–70%) in a warmer environment with its present volume, but decreases (3%–38%) substantially, when the volumes are reduced to half. However, such a decrease is found to be compensated by increased precipitation in a wetter scenario with a net increase of 3%–13%. Climate model simulations show a decrease in the spring onset times for Sutlej basin while increase for DK basin for both RCP4.5 and RCP8.5 scenarios. Sutlej and Arun basins show decreases of more than 6 days in the center of volume of streamflow, which suggests that there will be increased flows in the early part of year and reduced flows later in the year.
Reanalysis of Water Withdrawal for Irrigation, Electric Power, and Public Supply Sectors in the Conterminous United States, 1950–2016
Authors: McManamay Ryan A. , KC Binita , Allen‐Dumas Melissa R. , Kao Shih‐Chieh , Brelsford Christa M. , Ruddell Benjamin L. , Sanyal Jibonananda , Stewart Robert N. , Bhaduri Budhendra L. 
Published: January 2021

AbstractAccurately measuring water use by the economy is essential for developing reliable models of water resource availability. Indeed, these models rely on retrospective analyses that provide insights into shifting human population demands and adaptions to water shortages. However, accurate, methodologically consistent, empirically authentic, and spatiotemporally comprehensive historical datasets for water withdrawals are scarce. Herein, we present a reanalysis of annual resolution (1950–2016) historical data set on irrigation, electric power, and public supply water withdrawal within the conterminous United States (US) at the county‐level, and, for power plants, at the site‐level. To estimate electric power water use, we synthesized a historically comprehensive list of generators and historic patterns in generation across fuels, prime movers, and cooling technologies. Irrigation water use estimation required building a crop‐demand model that utilized historical information on irrigated acreage for crops and golf courses, stage‐specific crop water demand, and climate information. To estimate public water supply use, we developed a random forest model constructed from information on population, infrastructure, climate, and land cover. These estimates generally agree with total county and state water use information provided by the US Geological Survey (USGS) water use circular and estimates generated from independent studies for specific years. However, we also observed discrepancies between our estimates and USGS data that appear to be caused by inconsistencies in the methods used by the USGS's primary data sources at the state level over decades of data collection, highlighting the importance of reanalysis to yield spatiotemporally consistent and intercomparable estimates of water use.
The BET family in immunity and disease
Authors: Wang Nian , Wu Runliu , Tang Daolin , Kang Rui 
Published: January 2021

AbstractInnate immunity serves as the rapid and first-line defense against invading pathogens, and this process can be regulated at various levels, including epigenetic mechanisms. The bromodomain and extraterminal domain (BET) family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and BRDT) that regulate the expression of many immunity-associated genes and pathways. In particular, in response to infection and sterile inflammation, abnormally expressed or dysfunctional BETs are involved in the activation of pattern recognition receptor (e.g., TLR, NLR, and CGAS) pathways, thereby linking chromatin machinery to innate immunity under disease or pathological conditions. Mechanistically, the BET family controls the transcription of a wide range of proinflammatory and immunoregulatory genes by recognizing acetylated histones (mainly H3 and H4) and recruiting transcription factors (e.g., RELA) and transcription elongation complex (e.g., P-TEFb) to the chromatin, thereby promoting the phosphorylation of RNA polymerase II and subsequent transcription initiation and elongation. This review covers the accumulating data about the roles of the BET family in innate immunity, and discusses the attractive prospect of manipulating the BET family as a new treatment for disease.
Racial variations in tooth pain and care-seeking in adolescents in Malaysia
Authors: Tay Kangjie , Beh Cassandra Li Jean , Babar Muneer Gohar , Kweh Ting Jing , Priya Ekta , Pau Allan 
Published: January 2021

Abstract
Objective
Tooth pain among adolescents is a common event that impacts substantially on quality of life. The purpose of this paper is to explore the role of race in the tooth pain experience and associated care-seeking.

Design
A cross-sectional questionnaire survey was conducted on 14–18 years from four different public schools in Kuala Lumpur. Socio-demographic, pain symptoms, and social impacts data were collected as well as medication use and visiting a dentist for tooth pain.

Results
Of 1473 questionnaires distributed, 1452 (98.6%) completed questionnaires were returned, with 269 (18.5%) reported having experienced tooth pain in the past 1 month. Those who identified as Indian (26.1%) were more likely to report tooth pain compared to Chinese (16.5%) and Malay (20.9%). In regression analysis, no factors were identified as independently associated with medication use, but Chinese and Indians compared to Malays, and those expressing difficulty sleeping were more likely to report visiting a dentist for treatment.

Conclusion
Racial variations in the tooth pain experience and care-seeking have been identified. This may be related to socio-economic status, but further research is needed on the role of culture-related care-seeking and accessibility of dental services.
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
Authors: Du Jiqing , Wrisberg Marie-Kristin von , Gulen Burak , Stahl Matthias , Pett Christian , Hedberg Christian , Lang Kathrin , Schneider Sabine , Itzen Aymelt 
Published: January 2021

AbstractLegionella pneumophila infects eukaryotic cells by forming a replicative organelle – the Legionella containing vacuole. During this process, the bacterial protein DrrA/SidM is secreted and manipulates the activity and post-translational modification (PTM) states of the vesicular trafficking regulator Rab1. As a result, Rab1 is modified with an adenosine monophosphate (AMP), and this process is referred to as AMPylation. Here, we use a chemical approach to stabilise low-affinity Rab:DrrA complexes in a site-specific manner to gain insight into the molecular basis of the interaction between the Rab protein and the AMPylation domain of DrrA. The crystal structure of the Rab:DrrA complex reveals a previously unknown non-conventional Rab-binding site (NC-RBS). Biochemical characterisation demonstrates allosteric stimulation of the AMPylation activity of DrrA via Rab binding to the NC-RBS. We speculate that allosteric control of DrrA could in principle prevent random and potentially cytotoxic AMPylation in the host, thereby perhaps ensuring efficient infection by Legionella.
Mechanistic insight into copper cation exchange in cadmium selenide semiconductor nanocrystals using X-ray absorption spectroscopy
Authors: Khammang Alex , Wright Joshua T. , Meulenberg Robert W. 
Published: January 2021

AbstractIn terms of producing new advances in sustainable nanomaterials, cation exchange (CE) of post-processed colloidal nanocrystals (NCs) has opened new avenues towards producing non-toxic energy materials via simple chemical techniques. The main processes governing CE can be explained by considering hard/soft acid/base theory, but the detailed mechanism of CE, however, has been debated and has been attributed to both diffusion and vacancy processes. In this work, we have performed in situ x-ray absorption spectroscopy to further understand the mechanism of the CE of copper in solution phase CdSe NCs. The x-ray data indicates clear isosbestic points, suggestive of cooperative behavior as previously observed via optical spectroscopy. Examination of the extended x-ray absorption fine structure data points to the observation of interstitial impurities during the initial stages of CE, suggesting the diffusion process is the fundamental mechanism of CE in this system.
Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
Authors: Hörnblad A. , Bastide S. , Langenfeld K. , Langa F. , Spitz F. 
Published: January 2021

AbstractDevelopmental genes are often regulated by multiple elements with overlapping activity. Yet, in most cases, the relative function of those elements and their contribution to endogenous gene expression remain poorly characterized. An example of this phenomenon is that distinct sets of enhancers have been proposed to direct Fgf8 in the limb apical ectodermal ridge and the midbrain-hindbrain boundary. Using in vivo CRISPR/Cas9 genome engineering, we functionally dissect this complex regulatory ensemble and demonstrate two distinct regulatory logics. In the apical ectodermal ridge, the control of Fgf8 expression appears distributed between different enhancers. In contrast, we find that in the midbrain-hindbrain boundary, one of the three active enhancers is essential while the other two are dispensable. We further dissect the essential midbrain-hindbrain boundary enhancer to reveal that it is also composed by a mixture of essential and dispensable modules. Cross-species transgenic analysis of this enhancer suggests that its composition may have changed in the vertebrate lineage.
An optical neural chip for implementing complex-valued neural network
Authors: Zhang H. , Gu M. , Jiang X. D. , Thompson J. , Cai H. , Paesani S. , Santagati R. , Laing A. , Zhang Y. , Yung M. H. , Shi Y. Z. , Muhammad F. K. , Lo G. Q. , Luo X. S. , Dong B. , Kwong D. L. , Kwek L. C. , Liu A. Q. 
Published: January 2021

AbstractComplex-valued neural networks have many advantages over their real-valued counterparts. Conventional digital electronic computing platforms are incapable of executing truly complex-valued representations and operations. In contrast, optical computing platforms that encode information in both phase and magnitude can execute complex arithmetic by optical interference, offering significantly enhanced computational speed and energy efficiency. However, to date, most demonstrations of optical neural networks still only utilize conventional real-valued frameworks that are designed for digital computers, forfeiting many of the advantages of optical computing such as efficient complex-valued operations. In this article, we highlight an optical neural chip (ONC) that implements truly complex-valued neural networks. We benchmark the performance of our complex-valued ONC in four settings: simple Boolean tasks, species classification of an Iris dataset, classifying nonlinear datasets (Circle and Spiral), and handwriting recognition. Strong learning capabilities (i.e., high accuracy, fast convergence and the capability to construct nonlinear decision boundaries) are achieved by our complex-valued ONC compared to its real-valued counterpart.
Impact of the central frequency of environment on non-Markovian dynamics in piezoelectric optomechanical devices
Authors: Ding Quanzhen , Zhao Peng , Ma Yonghong , Chen Yusui 
Published: January 2021

AbstractThe piezoelectric optomechanical devices supply a promising experimental platform to realize the coherent and effective control and measurement of optical circuits working in Terahertz (THz) frequencies via superconducting electron devices typically working in Radio (MHz) frequencies. However, quantum fluctuations are unavoidable when the size of mechanical oscillators enter into the nanoscale. The consequences of the noisy environment are still challenging due to the lack of analytical tools. In this paper, a semi-classical and full-quantum model of piezoelectric optomechanical systems coupled to a noisy bosonic quantum environment are introduced and solved in terms of quantum-state diffusion (QSD) trajectories in the non-Markovian regime. We show that the noisy environment, particularly the central frequency of the environment, can enhance the entanglement generation between optical cavities and LC circuits in some parameter regimes. Moreover, we observe the critical points in the coefficient functions, which can lead the different behaviors in the system. Besides, we also witness the entanglement transfers between macroscopic objects due to the memory effect of the environment. Our work can be applied in the fields of electric/ optical switches, and long-distance distribution in a large-scale quantum network.
Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
Authors: Manyanga Jimmy , Ganapathy Vengatesh , Bouharati Célia , Mehta Toral , Sadhasivam Balaji , Acharya Pawan , Zhao Daniel , Queimado Lurdes 
Published: January 2021

AbstractTobacco smoking is the leading preventable cause of cancer. Moreover, continued smoking during cancer therapy reduces overall survival. Aware of the negative consequences of tobacco smoking and the challenges of smoking cessation, cancer patients are inquiring whether they should switch to electronic cigarettes (e-cigarettes). To obtain evidence-based data to inform this decision, we examined the effects of e-cigarette aerosol exposure on cisplatin resistance in head and neck cancer cells. Our results show that cancer cells exposed to e-cigarette aerosol extracts and treated with cisplatin have a significant decrease in cell death, increase in viability, and increase in clonogenic survival when compared to non-exposed cells. Moreover, exposure to e-cigarette aerosol extracts increased the concentration of cisplatin needed to induce a 50% reduction in cell growth (IC50) in a nicotine-independent manner. Tobacco smoke extracts induced similar increases in cisplatin resistance. Changes in the expression of drug influx and efflux transporters, rather than activation of cell growth-promoting pathways or DNA damage repair, contribute to e-cigarette induced cisplatin resistance. These results suggest that like combustible tobacco, e-cigarette use might increase chemotherapy resistance, and emphasize the urgent need for rigorous evaluation of e-cigarettes health effects to ensure evidence-based public health policies.
Single versus dual elastic nails for closed reduction and antegrade intramedullary nailing of displaced fifth metacarpal neck fractures
Authors: Zeng Langqing , Zeng Lulu , Miao Xiaogang , Chen Yunfeng , Liang Weiguo , Jiang Yuwen 
Published: January 2021

AbstractClosed reduction and internal fixation with antegrade intramedullary nails is a feasible and effective treatment for displaced fifth metacarpal neck fractures (FMNFs). The present study aimed to compare clinical and radiological outcomes in patients with displaced FMNFs after treatment with single or dual antegrade elastic intramedullary nails (AEIMNs). Thirty-three patients were treated with a single 2.0 mm AEIMN and 34 patients were treated with two 1.5 mm AEIMNs. Clinical and radiological outcomes included grip strength, active range of motion (ROM), active flexion and extension of the fifth metacarpophalangeal (MCP) joint, dorsal angulation loss, and metacarpal shortening of the fifth metacarpal at 12 months after treatment. No significant difference was observed between the two groups with respect to grip strength, ROM or flexion of the fifth MCP joint. The average values of dorsal angulation loss, metacarpal shortening, and extension of the fifth MCP joint of the dual nails group were better than those of the single nail group (dorsal angulation loss, 2.79 ± 1.93° vs. 4.05 ± 1.59°, P = 0.009; metacarpal shortening, 1.66 ± 0.80 mm vs. 2.12 ± 0.88 mm, P = 0.028; extension of the fifth MCP joint, 7.71 ± 4.43° vs. 4.82 ± 4.09°, P = 0.012). In conclusion, dual AEIMNs fixation provided better MCP extension and radiological outcomes than single AEIMN fixation.
Non-closed acoustic cloaking devices enabled by sequential-step linear coordinate transformations
Authors: Basiri Zahra , Fakheri Mohammad Hosein , Abdolali Ali , Shen Chen 
Published: January 2021

AbstractHitherto acoustic cloaking devices, which conceal objects externally, depend on objects' characteristics. Despite previous works, we design cloaking devices placed adjacent to an arbitrary object and make it invisible without the need to make it enclosed. Applying sequential linear coordinate transformations leads to a non-closed acoustic cloak with homogeneous materials, creating an open invisible region. Firstly, we propose to design a non-closed carpet cloak to conceal objects on a reflecting plane. Numerical simulations verify the cloaking effect, which is completely independent of the geometry and material properties of the hidden object. Moreover, we extend this idea to achieve a directional acoustic cloak with homogeneous materials that can render arbitrary objects in free space invisible to incident radiation. To demonstrate the feasibility of the realization, a non-resonant meta-atom is utilized which dramatically facilitated the physical realization of our design. Due to the simple acoustic constitutive parameters of the presented structures, this work paves the way toward realization of non-closed acoustic devices, which could find applications in airborne sound manipulation and underwater demands.
Clinical outcomes between calcium channel blockers and angiotensin receptor blockers in hypertensive patients without established cardiovascular diseases during a 3-year follow-up
Authors: Jeong Han Saem , Lim Hong‐Seok , Park Hun-Jun , Lee Wang-Soo , Choi Jin-Oh , Lee Hui Seung , Jo Sang-Ho , Hong Soon Jun 
Published: January 2021

AbstractAlthough both angiotensin receptor blockers (ARBs) and dihydropyridine calcium channel blockers (CCBs) are all suitable for the initiation of antihypertensive treatment, studies investigating efficacy and safety between ARBs and CCBs are limited, and there is no previous study comparing their clinical outcomes during long-term follow-up periods in real world setting. We compared cardiovascular (CV) events between ARBs and CCBs in 464,948 hypertensive adults using the Korean National Health Insurance Service database during a 3-year follow-up. The patients with hypertension without heart failure, ischemic heart disease, cerebrovascular disease, or peripheral artery disease were enrolled. The CV events between only single prescription of CCBs and ARBs were finally compared. The primary endpoint for this study was the first occurrence of a major adverse CV events, defined as the composite of all-cause death, cardiac death, nonfatal myocardial infarction, or nonfatal stroke. ARB was significantly more administered in male and patients with higher income, diabetes mellitus, chronic kidney diseases, and higher Charlson comorbidity index. The primary endpoints occurred in 10,526 patients (5.2%) in the ARB group and in 19,363 patients (7.3%) in the CCB group (p < 0.001) during a 3-year follow-up (HR 0.96, 95% CI 0.93–0.98). All the components of CV events including all-cause death, cardiac death, nonfatal myocardial infarction, and nonfatal stroke occurred more frequently in the CCB group. With multivariable models adjusting age, sex, income, diabetes, chronic kidney disease, and Charlson comorbidity index, the primary endpoints less frequently developed in the ARB group than in the CCB group (HR 0.957, 95% CI 0.933–0.983, p < 0.001). After the propensity-score matching, baseline characteristics were similar and still showed significantly better primary endpoints in ARB group than CCB group (5.3% vs. 5.8%, p < 0.001). In this nationwide population-based simple hypertension study, administration of ARBs showed superior protection against CV events than CCBs during a 3-year follow-up. Our results suggest that ARBs could be preferred over CCBs as the initial choice of antihypertensive treatment regardless of age in real-world practice.
Live cell dynamics of production, explosive release and killing activity of phage tail-like weapons for Pseudomonas kin exclusion
Authors: Vacheron Jordan , Heiman Clara Margot , Keel Christoph 
Published: January 2021

AbstractInterference competition among bacteria requires a highly specialized, narrow-spectrum weaponry when targeting closely-related competitors while sparing individuals from the same clonal population. Here we investigated mechanisms by which environmentally importantPseudomonasbacteria with plant-beneficial activity perform kin interference competition. We show that killing between phylogenetically closely-related strains involves contractile phage tail-like devices called R-tailocins that puncture target cell membranes. Using live-cell imaging, we evidence that R-tailocins are produced at the cell center, transported to the cell poles and ejected by explosive cell lysis. This enables their dispersal over several tens of micrometers to reach targeted cells. We visualize R-tailocin-mediated competition dynamics between closely-relatedPseudomonasstrains at the single-cell level, both in non-induced condition and upon artificial induction. We document the fatal impact of cellular self-sacrifice coupled to deployment of phage tail-like weaponry in the microenvironment of kin bacterial competitors, emphasizing the necessity for microscale assessment of microbial competitions.