bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seven-day Oral Intake of Orthosiphon stamineus Leaves Infusion Exerts Antiadhesive Ex Vivo Activity Against Uropathogenic E. coli in Urine Samples
Authors: Deipenbrock Melanie , Scotti Francesca , Mo Boris , Heinrich Michael , Hensel Andreas 
Published: September 2021

Abstract
Orthosiphon stamineus leaves (Java tea) extract is traditionally used for the treatment of urinary tract infections. According to recent in vitro data, animal infection
studies, and transcriptomic investigations, polymethoxylated flavones from Java tea exert antiadhesive activity against uropathogenic Escherichia coli (UPEC). This antiadhesive
activity has been shown to reduce bladder and kidney lesion in a mice infection model. As no data on the antivirulent activity of Java tea intake on humans are available, a biomedical study
was performed on 20 healthy volunteers who self-administered Orthosiphon infusion (4 × 3 g per day, orally) for 7 days. The herbal material used for the study conformed to the
specification of the European Pharmacopoeia, and ultra high-performance liquid chromatography (UHPLC) of the infusion showed rosmarinic acid, caffeic acid, and cichoric acid to be the main
compounds aside from polymethoxylated flavones. Rosmarinic acid was quantified in the tea preparations with 243 ± 22 µg/mL, indicating sufficient reproducibility of the preparation of the
infusion. Urine samples were obtained during the biomedical study on day 1 (control urine, prior to Java tea intake), 3, 6 and 8. Antiadhesive activity of the urine samples was quantified by
flowcytometric assay using pre-treated UPEC NU14 and human T24 bladder cells. Pooled urine samples indicated significant inhibition of bacterial adhesion on day 3, 6 and 8. The urine samples
had no influence on the invasion of UPEC into host cells. Bacterial proliferation was slightly reduced after 24 h incubation with the urine samples. Gene expression analysis (qPCR) revealed
strong induction of fitness and motility gene fliC and downregulation of hemin uptake system chuT. These data correlate with previously reported datasets from in vitro
transcriptomic analysis. Increased bacterial motility was monitored using a motility assay in soft agar with UPEC UTI89. The intake of Java tea had no effect on the concentration of
Tamm-Horsfall Protein in the urine samples. The present study explains the antiadhesive and anti-infective effect of the plant extract by triggering UPEC from a sessile lifestyle into a
motile bacterial form, with reduced adhesive capacity.
Positionspapier: Hinweise zur Patienteninformation und -aufklärung vor Anwendung von Biologika bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) – Teil 2: Omalizumab – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)
Authors: Förster-Ruhrmann U. , Beule A. G. , Becker S. , Chaker A. M. , Huppertz T. , Hagemann J. , Hoffmann T. K. , Dazert S. , Deitmer T. , Wrede H. , Schlenter W. , Welkoborsky H. J. , Wollenberg B. , Olze H. , Rudack C. , Sperl A. , Casper I. , Dietz A. , Wagenmann M. , Zuberbier T. , Bergmann K. C. , Bedbrook A. , Bousquet J. , Bachert C. , Bergmann C. , Klimek L. 
Published: September 2021

ZusammenfassungHintergrund Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entzündliche Erkrankung, oftmals auf der Grundlage einer Typ-2-Inflammation. Für die Behandlung von Patienten mit einer schweren Ausprägung ohne ausreichendes Ansprechen auf die Standardtherapie mit topischen nasalen Steroiden und/oder Zustand nach endonasaler Operation sind als Biologika aktuell Dupilumab und Omalizumab für die Therapie zugelassen. Nachdem wir in einer früheren Publikation für Dupilumab bereits entsprechende Hinweise gegeben haben, ist das Ziel der vorliegenden Arbeit die Standardisierung von Patienteninformation und -aufklärung vor einer Therapie mit Omalizumab.Methoden Auf Grundlage des aktuellen Wissensstandes zur Immunologie der CRSwNP und zu den erwünschten und möglichen unerwünschten Wirkungen von Omalizumab werden Empfehlungen für die Patienteninformation entwickelt.Ergebnisse Basierend auf der internationalen Literatur, der aktuellen Fachinformation und Erfahrungen aus der praktischen Anwendung und den derzeitigen Pharmakovigilanz-Daten hat ein Expertengremium Empfehlungen für die Patienteninformation und -aufklärung zur Anwendung von Omalizumab bei CRSwNP entwickelt und auf dieser Grundlage einen Patienteninformations- und Aufklärungsbogen erstellt.Schlussfolgerung Die Information und Einwilligung des Patienten wird vor der Verordnung bzw. Verabreichung von allen Biologika, damit auch Omalizumab, empfohlen. Das vorliegende Positionspapier enthält wichtige Informationen zur praktischen Umsetzung und einen Vorschlag für eine Patienteninformation.
Photodriven Dehydrogenative Homocoupling of Benzylic C–H Bonds Forming Strained C–C Bonds
Authors: Ishida Naoki , Murakami Masahiro , Son Mingon , Kawasaki Tairin , Ito Misato 
Published: September 2021

AbstractA photoinduced dehydrogenative homocoupling reaction of alkylarenes is reported. Gaseous hydrogen is evolved as the sole byproduct and neither oxidants nor hydrogen acceptors are required. The present reaction offers an environmentally benign and atom-economical means for forming sterically strained C–C single bonds. It also gives a remarkable example of photodriven reactions overcoming a considerable rise in energy.
Case Reporting in Homeopathy—An Overview of Guidelines and Scientific Tools
Authors: Teut Michael , van Haselen Robbert A. , Rutten Lex , Lamba Chetna Deep , Bleul Gerhard , Ulbrich-Zürni Susanne 
Published: September 2021

AbstractCase reports have been of central importance to the development of homeopathy over the past 200 years. With a special focus on homeopathy, we give an overview on guidelines and tools that may help to improve the quality of case reports. Reporting guidelines such as CARE (Case Report), HOM-CASE (Homeopathic Clinical Case Reports), and the WissHom Documentation Standard help to improve the quality of reporting and strengthen the scientific value of a case report. Additional scientific tools such as prospective outcome assessment, prognostic factor research, cognition-based medicine, and the Modified Naranjo Criteria for Homeopathy (MONARCH) score may be helpful in improving case documentation and evaluation.
Radiographic and Clinical Evolution of the Oxford Unicompartmental Knee Arthroplasty
Authors: D'Ambrosi Riccardo , da Silva Manuel J. de S.V. , Moura João L. M. , Mariani Ilaria , Serrao Luca D. , Di Feo Fabrizio , Ursino Nicola 
Published: September 2021

AbstractThe aim of the study is to evaluate whether the use of the new instrumentation Microplasty (MP) improves component positioning and the reliability of the surgical technique, reducing the implant outliers from the recommended range and providing a more accurate resection, while avoiding insufficient or excessive tibial resection and clinical scores. We prospectively analyzed clinical and radiographic outcomes of three consecutive cohorts for a total of 227 implants at a minimum follow-up of 36 months. The first cohort consisted of 67 Oxford unicompartmental knee arthroplasty (OUKA), using the phase III (Ph-III). The second cohort consisted of 136 OUKA, with the MP instrumentation. The third cohort consisted of 24 hypoallergenic OUKA, using the MP instrumentation (TiNbN). Postoperative alignment of the knee in the coronal and sagittal plane was measured using radiographs. No clinical differences were found among the three groups (p > 0.05). A significant difference was found on the slope between Ph-III and MP (p = 0.0005). Moreover, a significant difference was found in tibial angle and in tibial slope in arthroplasty with femoral size small (S), compared with size medium (M) or large (Ly) (tibia varus/valugs angle: p = 0.0484; tibial slope: p = 0.04). Similar results were found between small (AA, A, B) tibial size and large (C, D, E, F) tibial size for tibial varus/valgus (p = 0.03) angle and tibial slope (p = 0.003). A significant difference was found between Ph-III and MP in tibial slope in patients with body mass index (BMI) ≥25 kg/m2 (p = 0.0003). A positive correlation was noted between the femoral and tibial sizes and the tibial angle and the slope, and a negative correlation between weight and the tibial slope; furthermore, a positive correlation was found between Oxford knee score and radiographic angles. The MP instrumentation seems to be effective in determining the tibial cut and, particularly, improving the tibial slope, compared with Ph-III. The tibial slope is directly affected by the weight and measurements of the components, regardless of the instruments or the number of pegs, while clinical outcomes are correlated with implant position. This prospective comparative study reflects level of evidence II.
Does Incisional Negative Pressure Wound Therapy Prevent Sternal Wound Infections?
Authors: Myllykangas Heidi-Mari , Halonen Jari , Husso Annastiina , Väänänen Helli , Berg Leena T. 
Published: September 2021

AbstractBackground Incisional negative pressure wound therapy has been described as an effective method to prevent wound infections after open heart surgery in several publications. However, most studies have examined relatively small patient groups, only a few were randomized, and some have manufacturer-sponsorship. Most of the studies have utilized Prevena; there are only a few reports describing the PICO incisional negative pressure wound therapy system.Methods We conducted a prospective cohort study involving a propensity score-matched analysis to evaluate the effect of PICO incisional negative pressure wound therapy after coronary artery bypass grafting. A total of 180 high-risk patients with obesity or diabetes were included in the study group. The control group included 772 high-risk patients operated before the initiation of the study protocol.Results The rates of deep sternal wound infections in the PICO group and in the control group were 3.9 and 3.1%, respectively. The rates of superficial wound infections needing operative treatment were 3.1 and 0.8%, respectively. After propensity score matching with two groups of 174 patients, the incidence of both deep and superficial infections remained slightly elevated in the PICO group. None of the infections were due to technical difficulties or early interruption of the treatment.Conclusion It seems that incisional negative pressure wound therapy with PICO is not effective in preventing wound infections after coronary artery bypass grafting. The main difference in this study compared with previous reports is the relatively low incidence of infections in our control group.
Outcomes of Arch Reintervention for Recurrent Coarctation in Young Children
Authors: Jiang Qi , Hu Renjie , Dong Wei , Guo Ying , Zhang Wen , Hu Jie , Zhang Haibo 
Published: September 2021

Abstract
Objectives To evaluate the outcomes of reintervention for postrepair recoarctation in young children.
Methods Between January 2011 and December 2020, all consecutive patients aged ≤3 years who were treated for postrepair recoarctation were included. Recoarctations were classified into two morphological types by three-dimensional imaging. Two methods, namely, surgical repair and balloon angioplasty (BA), were used to treat recoarctation.
Results This study included 50 patients with a median age of 10.5 months (range, 2.0–36.0 months) and a mean weight of 9.3 ± 3.1 kg. Hypoplastic recoarctation occurred most frequently in patients who had undergone patch aortoplasty at initial repair (p = 0.001). No hospital mortality occurred, and all patients achieved an increased diameter (p < 0.001) and a decreased pressure gradient (p < 0.001) at the recoarctation site immediately after reintervention. The median follow-up time after reintervention was 3.5 years (range, 16.0 days–9.6 years). Late mortality occurred in four patients (8.0%): two in the surgical group and two in the BA group (chi-square test= 0.414, p = 0.520). There was no difference in arch reobstruction after reintervention between the surgical and BA groups (chi-square test = 1.383, p = 0.240). Recoarctation with a hypoplastic morphology was the leading risk factor for arch reobstruction after reintervention (hazard ratio, 6.552; 95% confidence interval, 2.045–20.992; p = 0.002).
Conclusion Reintervention for recoarctation has favorable early outcomes in young children. However, late mortality is not rare, and arch reobstruction is common during close follow-up. For young children, recoarctation with hypoplastic morphology is the leading risk factor for reobstruction, while the choice of reintervention method exerts little effect on the outcomes of arch reintervention.
Valve-in-Valve TAVR versus Redo Surgical Aortic Valve Replacement: Early Outcomes
Authors: Cizmic Amila , Kuhn Elmar , Eghbalzadeh Kaveh , Weber Carolyn , Rahmanian Parwis Baradaran , Adam Matti , Mauri Victor , Rudolph Tanja , Baldus Stephan , Wahlers Thorsten 
Published: September 2021

Abstract
Objective This study aimed to assess short-term outcomes of patients with failed aortic valve bioprosthesis undergoing valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) or redo surgical aortic valve replacement (rSAVR).
Methods Between 2009 and 2019, 90 patients who underwent ViV-TAVR (n = 73) or rSAVR (n = 17) due to failed aortic valve bioprosthesis fulfilled the inclusion criteria. Groups were compared regarding clinical end points, including in-hospital all-cause mortality. Patients with endocarditis and in a need of combined cardiac surgery were excluded from the study.
Results ViV-TAVR patients were older (78.0 ± 7.4 vs. 62.1 ± 16.2 years, p = 0.012) and showed a higher prevalence of baseline comorbidities such as atrial fibrillation, diabetes mellitus, hyperlipidemia, and arterial hypertension. In-hospital all-cause mortality was higher for rSAVR than in the ViV-TAVR group (17.6 vs. 0%, p < 0.001), whereas intensive care unit stay was more often complicated by blood transfusions for rSAVR patients without differences in cerebrovascular events. The paravalvular leak was detected in 52.1% ViV-TAVR patients compared with 0% among rSAVR patients (p < 0.001).
Conclusion ViV-TAVR can be a safe and feasible alternative treatment option in patients with degenerated aortic valve bioprosthesis. The choice of treatment should include the patient's individual characteristics considering ViV-TAVR as a standard of care.
Cranioplasty
Authors: Ong Adrian A. , Manning James P. , Vincent Aurora G. , Namin Arya W. , Wang Weitao , Ducic Yadranko 
Published: September 2021

AbstractCalvarial defects are commonly encountered after neurosurgical procedures, trauma, and ablative procedures of advanced head neck cancers. The goals of cranioplasty are to provide a protective barrier for the intracranial contents, to restore form, and prevent syndrome of the trephined. Autologous and alloplastic techniques are available, each with their advantages and drawbacks. A multitude of materials are available for cranioplasty, and proper timing of reconstruction with attention to the overlying skin envelope is important in minimizing complications.
Narrowing the Wide Tip via Endonasal Approach
Authors: Sulyman Omotara , Dayan Steven 
Published: September 2021

AbstractRhinoplasty is arguably the most complex and intricate surgery performed by facial plastic surgeons. Nasal tip refinement of a broad nasal tip has remained the most challenging part of rhinoplasty as sophisticated techniques are critical to achieve aesthetically pleasing and structurally sound nasal tips that can withstand the contractile forces of healing. Successful tip refinement relies on an in-depth preoperative and intraoperative understanding of the patient's nasal anatomy, well developed arsenal of techniques, the experience of the surgeon, and the aesthetic desires of the patient. Although the approach to gain access to the nasal tip so as to successfully reshape the tip has been a topic of debate over many years, the aim of this article is to outline and demonstrate how the broad nasal tip can be successfully recontoured through an endonasal approach using nondestructive techniques that have been effectively used in open rhinoplasty. We believe that there continues to be a place for endonasal tip rhinoplasty especially in this era in which patients desire less invasive procedures with shorter healing time.
Hybrid Implant Abutments: A Literature Review
Authors: Mostafavi Azam Sadat , Mojtahedi Hamid , Javanmard Afrooz 
Published: September 2021

AbstractCeramic implant abutments are becoming increasingly popular due to the growing esthetic demands of patients. Two-piece ceramic abutments have the advantages of both ceramic and titanium abutments. This study aimed to review the published articles regarding hybrid abutments and their characteristics.Published articles regarding two-piece abutments were retrieved by electronic search of PubMed, Embase, Scopus, Medline, and Google Scholar databases using certain keywords. Articles highly relevant to our topic of interest were selected and reviewed.The presence of titanium inserts in hybrid abutments can overcome the brittleness of ceramic, increase the overall fracture resistance, prevent the implant connection wear, and provide better marginal fit compared with one-piece zirconia abutments. Hybrid abutments enable the fabrication of monolithic metal-free implant restorations with optimal esthetics. Furthermore, the risk of porcelain chipping, which is a common complication of implant restorations, is eliminated due to the monolithic structure of these restorations.According to the available literature, hybrid implant abutments have shown promising results with regard to optimal esthetics in the rehabilitation of the esthetic zone. However, long-term clinical studies are required to assess the long-term durability of all-ceramic restorations supported by hybrid abutments.
Long-time measurements of line-integrated plasma electron density using a two-color homodyne optical fiber interferometer
Authors: Lan Tao , Zhang Sen , Ding Weixing , Zhuang Ge , Wu Zhengwei , Mao Wenzhe , Chen Chen , Lan Shijie , Xu Hangqi , Deng Tijian , Zhu Junfeng , Wu Jiaren , Zu Yiming , Kong Defeng , Zhang Shoubiao , Yao Yuan , Yuan Peng , Wei Zian , Zhou Haiyang , Wang Hai , Wen Xiaohui , Wu Jie , Zhou Chu , Liu Ahdi , Xie Jinlin , Li Hong , Xiao Chijin , Liu Wandong 
Published: September 2021

A two-color homodyne Mach–Zehnder (M–Z) optical fiber interferometer with wavelengths of 1.55 and 1.31 µm was developed for long-time measurement of line-integrated plasma electron density. A novel phase difference demodulation algorithm based on a single 3 × 3 optical coupler was implemented in a two-color optical fiber interferometer scheme for the first time. Our laboratory tests showed that this new optical fiber interferometer could determine the phase shift due to the low-frequency ambient vibration and could maintain high phase resolution measurement. The resolution of the new interferometer was less than 0.04 rad in 1000 s, corresponding to a line-averaged electron density of less than 1.0 × 1019 m−2. Actual plasma discharge experiments performed on KTX-CTI, which is a new compact torus injector (CTI) constructed at the Keda Torus eXperiment (KTX), showed that this interferometer has excellent several-second stability.
The sequence–ensemble relationship in fuzzy protein complexes
Authors: Hadži San , Loris Remy , Lah Jurij 
Published: September 2021

Significance
Intrinsically disordered proteins (IDPs) do not possess a stable three-dimensional structure but populate partially folded, transient structures. They are involved in numerous cellular processes, often in cooperation with globular proteins. In such complexes, the protein-bound IDPs can be structurally very heterogeneous ranging from folded, stable conformations to those that are dynamic and disordered. The underlaying principles governing this heterogeneity, known also as fuzziness, are obscure. We developed a simple statistical thermodynamic model based on the helix–coil theory that rationalizes diversity of the target-bound IDP ensembles. The model successfully reproduces bound-state IDP dynamics and explains how ensembles modulate their structure and interaction affinity due to mutations. Collectively, this sheds light on the sequence–ensemble relationship of fuzzy IDP–protein complexes.
Bcl6 controls meningeal Th17–B cell interaction in murine neuroinflammation
Authors: Hartlehnert Maike , Börsch Anna-Lena , Li Xiaolin , Burmeister Miriam , Gerwien Hanna , Schafflick David , Heming Michael , Lu I-Na , Narayanan Venu , Strecker Jan-Kolja , Kolz Anna , Peters Anneli , Wu Gregory F. , Wiendl Heinz , Sorokin Lydia , Meyer zu Horste Gerd 
Published: September 2021

Significance
The meninges protect the central nervous system but also host lymphocytes in neuroinflammation. In human multiple sclerosis, preferentially B cells accumulate in the meninges. By generating a compartment-specific transcriptional map of meningeal versus parenchymal leukocytes in experimental neuroinflammation, we found a follicular phenotype of meningeal B cells and a corresponding follicular helper-like phenotype in meningeal Th17 cells. The meninges thus instructed a site-specific local phenotype to proinflammatory autoreactive T cells. We identified the transcription factor Bcl6 in Th17 cells to promote interactions with meningeal B cells, isotype-switching, and B cell-supporting chemokines. This may describe a mechanism controlling meningeal autoimmunity and helps understanding how the meninges, as a recently recognized immunologically active site, contribute to autoimmune tissue damage in multiple sclerosis.
Ancestral polymorphisms shape the adaptive radiation ofMetrosiderosacross the Hawaiian Islands
Authors: Choi Jae Young , Dai Xiaoguang , Alam Ornob , Peng Julie Z. , Rughani Priyesh , Hickey Scott , Harrington Eoghan , Juul Sissel , Ayroles Julien F. , Purugganan Michael D. , Stacy Elizabeth A. 
Published: September 2021

SignificanceSome of the most spectacular adaptive radiations of plants and animals occur on remote oceanic islands, yet such radiations are preceded by founding events that severely limit genetic variation. How genetically depauperate founder populations give rise to the spectacular phenotypic and ecological diversity characteristic of island adaptive radiations is not known. We generated genomic resources for HawaiianMetrosideros––a hyper-variable adaptive radiation of woody taxa—for insights into the paradox of remote island radiations. We posit that divergent selection and differential sorting of an unexpectedly rich pool of ancestral variation drove the diversification of lineages. Recurring use of ancient variants from a richer-than-expected gene pool may explain how lineages can diversify to fill countless niches on remote islands.
Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life
Authors: Jenkins Lisanne M. , Kogan Alexandr , Malinab Matthew , Ingo Carson , Sedaghat Sanaz , Bryan Nick R. , Yaffe Kristine , Parrish Todd B. , Nemeth Alexander J. , Lloyd-Jones Donald M. , Launer Lenore J. , Wang Lei , Sorond Farzaneh 
Published: September 2021

SignificanceThe contribution of midlife vascular risk factors to brain structure and cognition in late life is well established. In this large cohort of midlife individuals, we replicated and extended previous findings of relationships between functional brain network connectivity and executive function in the context of white matter hyperintensities (WMH) and extended them to our measure of cumulative blood pressure exposure over 30 y from young adulthood. We report mediation of the relationship between WMH and executive function via functional connectivity. Our results support conclusions that neuroplastic reorganization of network connectivity may follow disruption to white matter tracks and furthermore suggest that this reorganization occurs early in the preclinical stage, prior to the onset of overt disease.