bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kombinasi Guided Imagery dan Musik Klasik Terhadap Tingkat Kecemasan Mahasiswa Menjelang Objective Structured Clinical Examination (OSCE)
Authors: Supriyana Dwi Surya , Rahmayanti Yeni Nur , Ambarsari Yeni 
Published: April 2021

<p align="center"><strong>ABSTRAK</strong></p><p align="center"><strong> </strong></p><p><strong>Pendahuluan</strong>: <em>Objective Structured Clinical Examination</em> (OSCE) merupakan metode untuk menguji kompetensi klinik secara obyektif dan terstruktur dalam bentuk putaran station dengan waktu tertentu. OSCE memunculkan perasaan takut, tegang, gelisah, sulit berkonsentrasi dan gangguan pencernaan pada mahasiswa. <em>Guided Imagery</em> yang dipadukan dengan intrumen musik klasik merupakan salah satu cara mengurangi kecemasan. Penelitian ini bertujuan untuk mengetahui pengaruh <em>Guided Imagery</em> terhadap tingkat kecemasan mahasiswa menjelang OSCE.</p><p><strong>Metode</strong>: Penelitian ini merupakan penelitian eksperimental kuasi dengan <em>pretest-posttest control group design</em>. Sampel penelitian adalah seluruh mahasiswa aktif semester pertama (angkatan 2019) Prodi Sarjana Keperawatan STIKes Mitra Husada Karanganyar sejumlah 32 orang dengan kriteria belum pernah mendapatkan terapi relaksasi <em>Guided Imagery</em> dan baru pertama kali menempuh OSCE. Teknik sampling yang digunakan adalah <em>purposive sampling</em>. Subjek penelitian dibagi menjadi dua kelompok, yakni kelompok perlakuan dan kelompok kontrol. Kelompok perlakuan mendapatkan terapi kombinasi <em>guided imagery</em> dengan musik klasik selama 5 hari berturut-turut menjelang waktu pelaksanaan OSCE dengan durasi waktu 20 menit. Pengaruh guided imagery terhadap tingkat kecemasan dianalisis menggunakan uji statistik <em>t independent.</em></p><p><strong>Hasil:</strong> Hasil penelitian menunjukan terdapat perbedaan rata-rata antara tingkat kecemasan pada kelompok eksperimen pretest 62.19±1.83 dan posttest 54.88±1.78. Kelompok kontrol rata-rata pretest 62.50±2.22 dan posttest 63.00±1.93. Nilai p (CI 95%) &lt; 0.05 (p=0.00) yang menunjukkan adanya pengaruh signifikan <em>Guided Imagery</em> terhadap penurunan tingkat kecemasan.</p><p><strong>Kesimpulan: </strong>terdapat pengaruh siginifikan pemberian kombinasi <em>guided imagery</em> dengan musik klasik terhadap penurunan tingkat kecemasan mahasiswa semester pertama program studi keperawatan menjelang OSCE.</p><p> </p><strong>Kata kunci: <em>Guided Imagery</em>, tingkat kecemasan, OSCE</strong>
High molecular weight sodium hyaluronate improves survival of syndecan-1-deficient septic mice by inhibiting neutrophil migration
Authors: Baljinnyam Tuvshintugs , Radnaa Enkhtuya , Ouellette Casey M. , Nelson Christina , Niimi Yosuke , Andersen Clark R. , Popov Vsevolod , Lee Jae-Woo , Prough Donald S. , Enkhbaatar Perenlei 
Published: April 2021

We investigated the role of endothelial glycocalyx and its component syndecan-1 protein in the pathophysiology of sepsis-induced vascular hyper-permeability and examined the therapeutic effects of high-molecular-weight sodium hyaluronate (HMW-SH).

Methods
Sepsis was induced by cotton smoke inhalation followed by intranasal administration of Pseudomonas aeruginosa in female (> 6 months) Balb/c and syndecan-1 knockout mice. Survival of mice, lung capillary endothelial glycocalyx integrity, lung water content, and vascular hyper-permeability were determined with or without HMW-SH treatment in these mice. Effects of HMW-SH on endothelial permeability and neutrophil migration were tested in in vitro setting.

Results
In septic wildtype mice, we found a severely damaged pulmonary microvascular endothelial glycocalyx and elevated levels of shed syndecan-1 in the circulation. These changes were associated with significantly increased pulmonary vascular permeability. In septic syndecan-1 knockout mice, extravascular lung water content was higher, and early death was observed. The administration of HMW-SH significantly reduced mortality and lung water content in septic syndecan-1 knockout mice, but not in septic wildtype mice. In in vitro setting, HMW-SH inhibited neutrophil migration and reduced cultured endothelial cell permeability increases. However, these effects were reversed by the addition of recombinant syndecan-1 ectodomain.

Conclusions
HMW-SH reduced lung tissue damage and mortality in the absence of syndecan-1 protein, possibly by reducing vascular hyper-permeability and neutrophil migration. Our results further suggest that increased shed syndecan-1 protein levels are linked with the inefficiency of HMW-SH in septic wildtype mice.
Systematic review and meta-analysis on juvenile primary spontaneous pneumothorax: Conservative or surgical approach first?
Authors: Hung Chun-Shan , Chen Yang-Ching , Yang Ten-Fang , Huang Fu-Huan 
Published: April 2021

Background
Primary spontaneous pneumothorax (PSP) prevalence is typically higher in juvenile patients than in adults. We aimed to evaluate the optimal treatment for primary spontaneous pneumothorax and its efficacy and safety in juveniles.

Materials and methods
We searched PubMed, Embase, and Cochrane databases for eligible studies published from database inception to October 10, 2020, and conducted a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The primary and secondary outcomes were recurrence rate and hospital stay length, respectively. Odds ratios (OR) and mean differences were used for quantitatively analyzing binary and continuous outcomes, respectively. In total, nine retrospective studies with 1,452 juvenile patients (aged <21) were included for the quantitative analysis. The surgical approach led to a lower recurrence rate than did conservative approaches (OR: 1.95, 95% confidence interval: 1.15–3.32). Moreover, the recurrence rate was low in patients who underwent conservative treatment first and received surgery later.

Conclusions
Surgical approach for first-line management might have a greater effect on recurrence prevention than do conservative approaches. An upfront surgery might be an optimal choice for juvenile primary spontaneous pneumothorax.
Biomechanical analysis of expert anesthesiologists and novice residents performing a simulated central venous access procedure
Authors: Villagrán Ignacio , Moënne-Loccoz Cristóbal , Aguilera Victoria , García Vicente , Reyes José Tomás , Rodríguez Sebastián , Miranda Constanza , Altermatt Fernando , Fuentes-López Eduardo , Delgado Mauricio , Neyem Andrés 
Published: April 2021

Background
Central venous access (CVA) is a frequent procedure taught in medical residencies. However, since CVA is a high-risk procedure requiring a detailed teaching and learning process to ensure trainee proficiency, it is necessary to determine objective differences between the expert’s and the novice’s performance to guide novice practitioners during their training process. This study compares experts’ and novices’ biomechanical variables during a simulated CVA performance.

Methods
Seven experts and seven novices were part of this study. The participants’ motion data during a CVA simulation procedure was collected using the Vicon Motion System. The procedure was divided into four stages for analysis, and each hand’s speed, acceleration, and jerk were obtained. Also, the procedural time was analyzed. Descriptive analysis and multilevel linear models with random intercept and interaction were used to analyze group, hand, and stage differences.

Results
There were statistically significant differences between experts and novices regarding time, speed, acceleration, and jerk during a simulated CVA performance. These differences vary significantly by the procedure stage for right-hand acceleration and left-hand jerk.

Conclusions
Experts take less time to perform the CVA procedure, which is reflected in higher speed, acceleration, and jerk values. This difference varies according to the procedure’s stage, depending on the hand and variable studied, demonstrating that these variables could play an essential role in differentiating between experts and novices, and could be used when designing training strategies.
Changing epidemiology of catheter-related bloodstream infections in neutropenic oncohematological patients
Authors: Lendak Dajana , Puerta-Alcalde Pedro , Moreno-García Estela , Chumbita Mariana , García-Pouton Nicole , Cardozo Celia , Morata Laura , Suárez-Lledó Maria , Hernández-Meneses Marta , Ghiglione Lucio , Marco Francesc , Martinez Jose Antonio , Mensa Josep , Urošević Ivana , Soriano Alex , Garcia-Vidal Carolina 
Published: April 2021

Background
We aimed to describe the epidemiology of catheter-related bloodstream infections (CRBSIs) in onco-hematological neutropenic patients during a 25-year study period, to evaluate the risk factors for Gram-negative bacilli (GNB) CRBSI, as well as rates of inappropriate empirical antibiotic treatments (IEAT) and mortality.

Materials/Methods
All consecutive episodes of CRBSIs were prospectively collected (1994–2018). Changing epidemiology was evaluated comparing five-year time spans. A multivariate regression model was built to evaluate risk factors for GNB CRBSIs.

Results
482 monomicrobial CRBSIs were documented. The proportion of CRBSIs among all BSIs decreased over time from 41.2% to 15.8% (p<0.001). CRBSIs epidemiology has been changing: the rate of GNB increased over time (from 11.9% to 29.4%; p<0.001), as well as the absolute number and rate of multidrug-resistant (MDR) GNB (from 9.5% to 40.0%; p = 0.039). P. aeruginosa increased and comprised up to 40% of all GNB. Independent factors related with GNB-CRBSIs were: longer duration of in-situ catheter (OR 1.007; 95%CI 1.004–1.011), older age (OR 1.016; 95%CI 1.001–1.033), prior antibiotic treatment with penicillins (OR 2.716; 95%CI 1.306–5.403), and current antibiotic treatment with glycopeptides (OR 1.931; 95%CI 1.001–3.306). IEATs were administered to 30.7% of patients, with the highest percentage among MDR P. aeruginosa (76.9%) and S. maltophillia (92.9%). Mortality rate was greater among GNB than GPC-CRBSI (14.4% vs 5.4%; p = 0.002), with mortality increasing over time (from 4.5% to 11.2%; p = 0.003).

Conclusion
A significant shift towards GNB-CRBSIs was observed. Secondarily, and coinciding with an increasing number of GNB-MDR infections, mortality increased over time.
Clinical-CT mismatch defined NIHSS ≥ 8 and CT-ASPECTS ≥ 9 as a reliable marker of candidacy for intravenous thrombolytic therapy in acute ischemic stroke
Authors: Wu Hung-Ming , Lee I-Hui , Luo Chao-Bao , Chung Chih-Ping , Lin Yung-Yang 
Published: April 2021

Background
Clinical-diffusion mismatch between stroke severity and diffusion-weighted imaging lesion volume seems to identify stroke patients with penumbra. However, urgent magnetic resonance imaging is sometimes inaccessible or contraindicated. Thus, we hypothesized that using brain computed tomography (CT) to determine a baseline “clinical-CT mismatch” may also predict the responses to thrombolytic therapy.

Methods
Brain CT lesions were measured using the Alberta Stroke Program Early CT Score (ASPECTS). A total of 104 patients were included: 79 patients with a baseline National Institutes of Health Stroke Scale (NIHSS) score ≥ 8 and a CT-ASPECTS ≥ 9 who were defined as clinical-CT mismatch-positive (P group) and 25 patients with an NIHSS score ≥ 8 and a CT-ASPECTS < 9 who were defined as clinical-CT mismatch-negative (the N group). We compared their clinical outcomes, including early neurological improvement (ENI), early neurological deterioration (END), delta NIHSS score (admission NIHSS—baseline NIHSS score), symptomatic intracranial hemorrhage (sICH), mortality, and favorable outcome at 3 months.

Results
Patients in the P group had a greater proportion of favorable outcome at 3 months (p = 0.032) and more frequent ENI (p = 0.038) and a greater delta NIHSS score (p = 0.001), as well as a lower proportion of END (p = 0.004) than those in the N group patients. There were no significant differences in the incidence rates of sICH and mortality between the two groups.

Conclusions
Clinical-CT mismatch may be able to predict which patients would benefit from intravenous thrombolysis.
Between inhibitors and repurposed drugs: COVID19 pharmacological approaches based on virus pathological life cycle
Authors: Baioumy Heba 
Published: April 2021

Commendable efforts are being invested to combat CoronaVIrus Disease-19 (COVID-19) through drug repurposing and developing an effective vaccine. Since the declaration of the outbreak of COVID19 by the WHO, scientists, researchers, and healthcare providers are collaborating worldwide to find a cure against the causative virus
SARS CoV-2 through drug repurposing (also known as drug repositioning). The therapeutic inhibition of a virus infection involves several targets from various steps of the virus life cycle; such as receptor-binding, cell fusion, virus replication, and release of virions. Researchers have established that SARS CoV-1, MERS and SARS CoV-2 fuse with the host cell through their S spike. Two pathways of viral cell entry are proposed: TMPRSS2 dependent pathway and TMPRSS2-independent pathway. Researches also showed through in-silico studies that drugs could work similarly on them. According to a fusion-assay study in 2005 on SARS CoV-1 cell entry, Cathepsin protease L (CatL) induced viral entry in a pH dependant manner; the optimum being acidic pH (Lysosomes). A recent in-vitro study published in 2020, added that CatL continues S1 subunit degradation in the acidic endosome and lysosome compartments. Several studies have published possible candidates blocking the two pathways for virus cell-entry before its replication in the host. Clinical documentations over the past year have shown that the severity of SARS CoV-2 lingers beyond reducing viral load due to the inflammatory response resulting in a cytokine storm. Hence, we hereby take the opportunity to highlight that the use of Ulinastatin could greatly benefit moderate and severe cases of COVID19 and reduce mortality as an addition to a comprehensive protocol.
Waste foundry sand characterization as paving aggregate
Authors: Dyer Paulo Paiva , Silva Silvelene Alessandra , Klinsky Luis Miguel Gutierrez , Coppio Gustavo Lauer , De Lima Maryangela Geimba 
Published: April 2021

Waste Foundry Sands (WFS) are by-products of the steel industry due to the foundry process. The residual material can be used in civil construction as an aggregate because of its mineral origin. This paper aimed to characterize the WFS obtained at two sources, using laboratory tests that are regularly required in highway engineering specifications. The laboratory program showed that the tests results satisfy the main specifications in Brazil. Laboratory tests results also show that WFS has characteristics that are similar to the manufactured sand that is usually used in asphalt pavement construction. It is concluded that the WFS could be used in asphalt pavement projects, as a subgrade reinforcement, sub-base or base layer and in asphalt wearing courses.
Pengaruh Booklet Terhadap Pengetahuan dan Sikap Kesehatan Reproduksi Calon Pengantin Terkait Pencegahan Risiko Kehamilan di Kabupaten Pemalang
Authors: Irawati Heni , Kartini Apoina , Nugraheni Sri Achadi 
Published: April 2021

One of the causes of a high maternal mortality rate is the low knowledge of women's reproductive health, especially about the prevention of pregnancy risks. This can be overcome by increasing the knowledge of prospective brides, one of them is by providing health education with booklet media. The purpose of this study was to determine the effect of booklets on the knowledge and attitudes of reproductive health of brides related to the prevention of the pregnancy risks. This type of research is quasi-experimental with a non-equivalent control group design. The study population was the future brides who attended the course of Future Bride and Groom at the Religious Affairs Office in Pemalang Regency. The samples were 50 brides for the intervention group and 50 brides for the control group. The instruments were questionnaires and booklets. An intervention group and a control group were compared based on the result of pre and post intervention. Statistical analysis used t-test and mann whitney test. The results showed that there is a differentiation in reproductive health knowledge after intervention between intervention group and control group (p = 0,000 <0,05) and there is a differentiation in reproductive health attitudes after intervention between intervention group and control group (p = 0,008 <0,05). The knowledge average of future brides increased by 4.28 points and the attitude average increased by 1.84 points after intervention. It can be concluded that the booklet can be used to increase the reproductive health knowledge and attitudes of future brides in prevention of pregnancy risks, especially in the case of anemia causing bleeding, chronic energy deficiency, and puerperal danger signs. It is recommended that the booklet can be developed as a media for reproductive health education in the course of Bride and Groom at the Religious Affairs Office.Key Words: Reproductive health; Knowledge; Attitudes; Booklet; Brides
Evaluasi Kelayakan Implementasi Sistem Informasi Surveilans Kesehatan Ibu Anak dan Gizi dengan Model Task Technology Fit di Kabupaten Banyumas
Authors: Pamungkas Sri Bintang , Agushybana Farid , Adi Kusworo 
Published: April 2021

Banyumas Regency already has a supportive system in terms of maternal health and child health surveillance but has not been utilized optimally because it has not gone through a competent feasibility study, so the system cannot be applied according due needs. The purpose of this study is noticing at the feasibility study of the child maternal health surveillance system and nutrition in its application at Banyumas regency by using Task Technology Fit (TTF). Research is a quantitative study with a cross sectional approach. Respondents of this study were all coordinate midwives in the puskesmas in Banyumas regency which amounts totaling 39 people, according to the predetermined total sampling criteria. Data collection using a questionnaire method. Data analysis was performed using logistic regression. The results of the feasibility study of the maternal and child health health surveillance system in Banyumas District showed variables related to utilization including data suitability, system reliability, ease of use. The recommendation for the improvement of the feasibility study of maternal and child health health surveillance systems in Banyumas district is the improvement of infrastructure, as well as training and socialization.
CO2 valorization into synthetic natural gas (SNG) using a Co–Ni bimetallic Y2O3 based catalysts
Authors: El-Salamony Radwa A. , El-Sharaky Sara A. , Al-Temtamy Seham A. , Al-Sabagh Ahmed M. , Killa Hamada M. 
Published: April 2021

Abstract
Recently, because of the increasing demand for natural gas and the reduction of greenhouse gases, interests have focused on producing synthetic natural gas (SNG), which is suggested as an important future energy carrier. Hydrogenation of CO2, the so-called methanation reaction, is a suitable technique for the fixation of CO2. Nickel supported on yttrium oxide and promoted with cobalt were prepared by the wet-impregnation method respectively and characterized using SBET, XRD, FTIR, XPS, TPR, and HRTEM/EDX. CO2 hydrogenation over the Ni/Y2O3 catalyst was examined and compared with Co–Ni/Y2O3 catalysts, Co% = 10 and 15 wt/wt. The catalytic test was conducted with the use of a fixed-bed reactor under atmospheric pressure. The catalytic performance temperature was 350 °C with a supply of H2:CO2 molar ratio of 4 and a total flow rate of 200 mL/min. The CH4 yield was reached 67%, and CO2 conversion extended 48.5% with CO traces over 10Co–Ni/Y2O3 catalyst. This encourages the direct methanation reaction mechanism. However, the reaction mechanism over Ni/Y2O3 catalyst shows different behaviors rather than that over bi-metal catalysts, whereas the steam reforming of methane reaction was arisen associated with methane consumption besides increase in H2 and CO formation; at the same temperature reaction.
Information Needs of Women Subsistence Farmers in the Dlangubo Village, South Africa
Authors: Zimu-Biyela Nomusa 
Published: April 2021

Abstract
Subsistence farming is important for food security and thus breaking the poverty cycle. Notwithstanding that, in many developing countries including South Africa, the development of women in rural areas remains a major concern. The purpose of this study was to explore information needs of women subsistence farmers and thus contribute to the already existing body of knowledge. Qualitative data were collected using semi-structured interviews, participant observation and focus group discussions. Grounded theory helped in data analysis. The use of Wilson’s model and the farmer-to-farmer extension (FFE) model helped in understanding the information need monitoring chain of women subsistence farmers. Findings revealed that they had both expressed and unexpressed information needs. Expressed needs included information about the recycling of seeds, soil fertility management, controlling of pests and stray animals, drought management skills, how to transcend from subsistence to commercial farming, and how to build strong social structures. Women livestock keepers needed information regarding drought management, support for livestock feeds, primary healthcare services for their livestock and support services for their extension officer who was deployed to another area. Unexpressed needs included the need for adult education as most women subsistence farmers had low levels of information literacy skills. It transpired that the word of mouth was the main source of information. The other sources of information such as radios, television and cell phones were used at a very limited rate. Local libraries were not sufficiently reaching out to respond to the women information needs. It is recommended that local libraries become visible and engage in library-led projects that can help meet women’s information needs and thus improve their living standards.
Difference-frequency generation in optically poled silicon nitride waveguides
Authors: Sahin Ezgi , Zabelich Boris , Yakar Ozan , Nitiss Edgars , Liu Junqiu , Wang Rui N. , Kippenberg Tobias J. , Brès Camille-Sophie 
Published: April 2021

Abstract
Difference-frequency generation (DFG) is elemental for nonlinear parametric processes such as optical parametric oscillation and is instrumental for generating coherent light at long wavelengths, especially in the middle infrared. Second-order nonlinear frequency conversion processes like DFG require a second-order susceptibility χ
(2), which is absent in centrosymmetric materials, e.g. silicon-based platforms. All-optical poling is a versatile method for inducing an effective χ
(2) in centrosymmetric materials through periodic self-organization of charges. Such all-optically inscribed grating can compensate for the absence of the inherent second-order nonlinearity in integrated photonics platforms. Relying on this induced effective χ
(2) in stoichiometric silicon nitride (Si3N4) waveguides, second-order nonlinear frequency conversion processes, such as second-harmonic generation, were previously demonstrated. However up to now, DFG remained out of reach. Here, we report both near- and non-degenerate DFG in all-optically poled Si3N4 waveguides. Exploiting dispersion engineering, particularly rethinking how dispersion can be leveraged to satisfy multiple processes simultaneously, we unlock nonlinear frequency conversion near 2 μm relying on all-optical poling at telecommunication wavelengths. The experimental results are in excellent agreement with theoretically predicted behaviours, validating our approach and opening the way for the design of new types of integrated sources in silicon photonics.