bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age moderates the relationships between obesity, glucose variability, and intensive care unit mortality: a retrospective cohort study
Authors: Lu Lusi , Lu Yifeng , Gao Chenlu , Zhang Nan 
Published: October 2021

Abstract
Background
Although the associations between obesity, glucose variability (GV), and Intensive Care Unit (ICU) mortality have been studied extensively, whether age moderates these associations is not well understood.

Materials and methods
The medical records of 1062 patients, who were admitted into ICU at Sir Run Run Shaw Hospital (Zhejiang, China), were studied. Logistic regression was used to test the associations between obesity, GV, and ICU mortality. Furthermore, the moderation effect of age was tested.

Results
After controlling for covariates, the underweight group had the highest odds of death (OR 2.38, 95% CI 1.43–3.95, p < 0.001) in comparison with the control group (overweight). However, normal weight (OR 1.29, 95% CI 0.88–1.89, p = 0.185) and obese (OR 1.08, 95% CI 0.61–1.90, p = 0.790) groups had similar odds of death, compared to the overweight group. Age significantly moderated the association between obesity and mortality, where being overweight was more advantageous than being normal weight in older adults (B = 0.03, SE = 0.01, OR 1.03, 95% CI 1.001–1.06, p = 0.045). Meanwhile, higher GV predicted greater mortality in adjusted models (OR 1.23, 95% CI 1.06–1.42, p = 0.005). We also found an interaction between age and GV (B = − 0.01, SE = 0.01, OR 0.99, 95% CI 0.98–0.999, p = 0.025), which suggested that the association between GV and mortality becomes weaker with increasing age.

Conclusions
With increasing age, the association between BMI and mortality becomes stronger and the association between glucose variability and mortality becomes weaker. Future studies should investigate the underlying mechanisms of such phenomenon and the causal relationship between obesity, GV, and ICU mortality.
Women’s career confidence in a fixed, sexist STEM environment
Authors: Clark Sheri L. , Dyar Christina , Inman Elizabeth M. , Maung Nina , London Bonita 
Published: October 2021

Abstract
Background
Innovation in STEM (science, technology, engineering, and math) fields in the U.S. is threatened by a lack of diversity. Social identity threat research finds messages in the academic environment devalue women and underrepresented groups in STEM, creating a chilly and hostile environment. Research has focused on the mechanisms that contribute to STEM engagement and interest at the K-12 and undergraduate level, but the mechanisms that predict sustained engagement at the graduate level have not been studied.

Results
In a longitudinal study of doctoral students in STEM disciplines, we demonstrate that students’ beliefs that their STEM colleagues believe intelligence is a fixed (vs. malleable) trait undermine women’s engagement in STEM. Specifically, perceiving a fixed ability environment predicts greater perceptions of sexism, which erode women’s self-efficacy and sense of belongingness and lead women to consider dropping out of their STEM career.

Conclusion
These findings identify one potential pathway by which women leave their STEM fields, perpetuating gender disparities in STEM.
An overview on current molecular tools for heterologous gene expression in Trichoderma
Authors: Tomico-Cuenca Irene , Mach Robert L. , Mach-Aigner Astrid R. , Derntl Christian 
Published: October 2021

AbstractFungi of the genus Trichoderma are routinely used as biocontrol agents and for the production of industrial enzymes. Trichoderma spp. are interesting hosts for heterologous gene expression because their saprotrophic and mycoparasitic lifestyles enable them to thrive on a large number of nutrient sources and some members of this genus are generally recognized as safe (GRAS status). In this review, we summarize and discuss several aspects involved in heterologous gene expression in Trichoderma, including transformation methods, genome editing strategies, native and synthetic expression systems and implications of protein secretion. This review focuses on the industrial workhorse Trichoderma reesei because this fungus is the best-studied member of this genus for protein expression and secretion. However, the discussed strategies and tools can be expected to be transferable to other Trichoderma species.
A case of laparoscopic partial hepatic S7 resection for postoperative liver metastasis of rectal malignant melanoma
Authors: Takahashi Makoto , Morita Yasuhiro , Hayashi Tatsuya , Yanagibashi Susumu , Sato Shunsuke , Sasaki Shu , Takuma Kunio , Okada Haruka 
Published: October 2021

Abstract
Background
Anorectal malignant melanoma (ARMM) has an extremely poor prognosis, and there is no report of resection of liver metastases so far. We report herein a rare case of postoperative laparoscopic partial hepatic S7 resection for rectal malignant melanoma.

Case presentation
A 51-year-old female patient with a diagnosis of an ARMM underwent a laparoscopic rectal amputation. Eleven months later, computed tomography (CT) revealed a 14-mm nodule in liver segment 7 (S7), which was diagnosed as a hepatic recurrence of the ARMM. Because no other recurrences were found, a laparoscopic partial resection of S7 was performed. Pathological analysis found intracellular melanin deposition, and immunostaining was S-100 (+), HMB-45 (+), and SOX-10 (+). Based on these findings, a liver metastasis of malignant melanoma was diagnosed. The patient is alive 7 months after the second surgery and has so far experienced no recurrences.

Conclusion
We reported an extremely rare case of a laparoscopic resection of a liver metastasis following surgery for ARMM.
More than just a urinary catheter: achieving hemostasis using Foley catheter in deep cerebral cavities—technical nuances
Authors: Sanjeevi Venkatesan , Roopesh Kumar V. R. 
Published: October 2021

Abstract
Background
Achieving hemostasis during neurosurgical procedures within deep seated tumors is of paramount importance. Chemical methods like using ORC and gel foam are preferred to bipolar cautery as bipolar cautery causes thermal injury to the normal eloquent surrounding white matter fibers, thereby causing significant morbidities. In addition to the chemical methods, we advocate a new relatively simple mechanical method by using small size Foley catheter inflated with saline can achieve hemostasis in case of deep locating brain tumor surgery with diffuse oozing from the tumor bed and surrounding white matter tissues are of concern. The balloon tamponade effect of the inflated Foley catheter helps in achieving complete hemostasis without damaging the surrounding normal white matter parenchyma.

Case presentation
A 52-years-old female admitted with history of progressive drowsiness and altered sensorium. Brain MRI was done showing large right-sided trigonal meningioma. Right parieto-occipital craniotomy was done, through the superior parietal lobe, corticotomy was done, and tumor was reached. Gentle retraction was done using curved blades in between the tumor and normal brain parenchyma. During surgery, following tumor removal, there was a diffuse oozing from tumor bed and the surrounding stretched white matter fibers. Hemostasis was attempted with chemical methods like ORC and gel foam. We avoided bipolar cautery to prevent thermal injury to the normal stretched eloquent white matter, as bleeding was not settled over the period of 45 min using chemical methods. Then, we placed a 10 F size Foley catheter in the tumor cavity and inflated with 6 ml of saline over the period of 10 min. Prior to Foley placement, we coated ORC over the tumor bed and the surrounding white matter. This achieved hemostasis to a significant extent and the same was repeated for another 10 min, and finally, complete hemostasis was achieved. Postoperative period went uneventful. Patient was discharged with good neurological recovery.

Conclusion
Inflatable Foley catheter balloon is a simple, cost-effective technique for achieving hemostasis in deep white matter tumors in addition to the routinely available hemostatic techniques.
Σύγχρονες τάσεις στο ελληνικό κουκλοθέατρο.
Authors: Παρούση Αντιγόνη , Λενακάκης Αντώνης 
Published: October 2021

Σε μια χρονική περίοδο όπου ανατροπές κοινωνικών και πολιτικών αυτονόητων βάζουν σε δοκιμασία την τέχνη του κουκλοθέατρου, την εκπαίδευση και κατά μείζονα λόγo τη σχέση του θεάτρου με την εκπαίδευση, η ψηφιακή έκδοση αυτού του τόμου φιλοδοξεί να παρουσιάσει προς ένα ευρύ κοινό το «σήμερα» του ελληνικού κουκλοθέατρου, το οποίο διαφέρει κατά πολύ από τη στερεοτυπική εικόνα που κυκλοφορεί σε μεγάλο μέρος του εκπαιδευτικού κόσμου. Ο τόμος φιλοδοξεί να αποτυπώσει, κατά το δυνατόν, τη δυναμική της ύπαρξής του και της ιστορία του, μια ιστορία που πείθει ότι όσο κι αν υποτιμήθηκε ως θεατρικό είδος, όσους αποκλεισμούς και αν δέχτηκε, είναι εδώ και συνεχίζει να ψυχαγωγεί αλλά και να «διαβρώνει» με τα ιδιαίτερα χαρακτηριστικά του τόσο τους χώρους της εκπαίδευσης όσο και αυτούς των άλλων τεχνών.
[Για την αγγλική έκδοση του τόμου δείτε εδώ: https://doi.org/10.12681/ecdnkua.192]
P2P lending platforms in Malaysia: What do we know?
Authors: Nguyen Lan Thi Phuong , Kalabeke Wisdom , Muthaiyah Saravanan , Cheng Ming Yu , Hui Kwan Jing , Mohamed Hazik 
Published: October 2021

Background - With the recent evolution of Financial Technology (FinTech), 11 peers to peer (P2P) lending platforms have been regulated by the Securities Commission in Malaysia since 2016. P2P lending platforms offer new investment opportunities to individual investors to earn higher rates on return than what traditional lenders usually provide. However, individual investors may face higher potential risks of default from their borrowers. Therefore, individual investors need to understand the potential exposure to such P2P lending platforms to make an effective investment decision. This study aims to explore the potential risk exposures that individual investors may experience at Malaysia's licensed P2P lending platforms. Methods - Based on data collected manually from nine P2P lending platforms over five months, relationships between interest rates and various risk classifying factors such as credit rating, industry, business stage, loan purpose, and loan duration are examined. Results- This study shows that loans with a similar credit rating and with or without similar loan purpose; and a business stage may offer investors significantly different interest rates. In addition, loans with shorter durations may provide investors with higher interest rates than those with longer durations. Finally, loans issued by companies from the same industry appeared to be charged with similar interest. These findings are valuable to investors to prepare themselves before making their investments at the P2P lending platforms. Conclusion- With first hand-collected data, this study provides an original insight into Malaysia's current P2P lending platforms. Findings obtained for relationships between interest rates and risk classifying factors such as credit rating, industry, business stage, loan purpose and loan duration are valuable to investors of Malaysian P2P lending platforms.
ТЕСТ ОЦЕНКИ УРОВНЯ ПЕРЦЕПТИВНОГО ДОВЕРИЯ
Authors: Dontsov Aleksandr I. , Kornilova Veronika S. 
Published: October 2021

Актуальность. Вопрос об оценке уровня сформированного перцептивного доверия, возникающего при восприятии незнакомого лица в короткий промежуток времени, важен в плане растущего интереса к феномену доверия.
Цель. Разработать тест, направленный на оценку уровня доверия к незнакомым людям и оценку его психометрических свойств (надeжность, валидность).
Методы исследования. В процессе работы применялись общенаучные методы: теоретического анализа, сравнительного анализа, обобщения. Среди специальных методов были использованы: методы сбора информации (опрос в очной (интервью) и заочной форме (анкетирование)); анализ собранных данных с использованием сравнения, обобщения; методы обработки данных: статистическая обработка данных производилась с помощью программы IBM SPSS Statistics 27.
Результаты. В статье изложены основные результаты психометрической проверки разработанного теста, направленного на оценку уровня перцептивного доверия. Предложен авторский вариант построения теста, который состоит из вопросов, представляющих собой ситуации, провоцирующие доверие.
Область применения результатов. Разработанный тест можно использовать в исследовательских целях для оценки уровня перцептивного доверия, а также для определения значимости зрительного контакта для формирования доверия.
A Study on the Impact and Potential of Cryptocurrency
Authors: Srivastava Aviral 
Published: October 2021

Introduction: Cryptocurrency is an innovative decentralized virtual currency concept. It has emerged as a new type of investment vehicle in the world, much like gold. The current research was carried out to investigate the impact of cryptocurrency on the world market and its future potential in relation to its rising prominence among investors and traders alike.
Methods: This descriptive-analytical study was based on the interviews of individuals trading in cryptocurrencies and data collected from magazines, websites, electronic newspapers, and research articles. The collected data sets were analyzed by a data analysis model created by me.
Results: Only Cryptocurrencies with decentralized systems are trusted by investors for the fact that they can't be controlled by a single entity. Some countries have legalized crypto while some have banned them. Overall, a majority of the world still has yet to comment on the legality of Bitcoin. The cryptocurrency market is highly volatile as it is based on a simple supply and demand strategy. Bitcoin mining generates 35.95 million tons of carbon dioxide emissions and 12,000 tons of electronic waste a year. The applications of this system promise free, fast transactions, a guarantee of privacy, and a traceable supply-chain framework.
Conclusion: The findings indicated that cryptocurrency has a
swiftly rising user base. With its fair share of advantages and disadvantages, it is a global phenomenon. Given the correlation between investors and asset flow, its future
looks promising. It is necessary to promote this next chapter in the evolution of digital assets.
PENUNDAAN KEWAJIBAN PEMBAYARAN UTANG (PKPU) DALAM MASA PANDEMI COVID-19: ANTARA SOLUSI DAN JEBAKAN
Authors: Budiyono Tri 
Published: October 2021

Dunia Bisnis terpapar oleh pandemi Covid-19. Bagi pengusaha yang memiliki kewajiban membayar hutang, dapat dimohonkan pailit yang pada umumnya akan mengakibatkan terhentinya kegiatan usaha. Untuk menghindari kebangkrutan, debitur dapat mencari formula lain sebagai jalan keluar dari masalah itu. Tujuan penelitian ini adalah untuk mengeksplorasi (kemungkinan) pemanfaatan PKPU dalam masa Covid-19, termasuk kelemahan yang dihadapi oleh pelaku usaha. Penelitian ini adalah penelitian hukum yuridis normatif, dengan pendekatan filosofis dan pendekatan konseptual. Temuan penelitian ini adalah bahwa titik penghubung antara PKPU dan kepailitan menjadi solusi namun mengandung potensi jebakan yang dapat berakibat fatal bagi debitur. Oleh karena itu, debitur harus cermat dalam memilih pola penyelesaian utang yang memiliki risiko paling kecil. Restrukturisasi kredit atau pembiayaan memiliki risiko rendah bagi debitur, sedang PKPU lebih baik diposisikan sebagai pilihan terakhir.
Budget sharing for multi-analyst differential privacy
Authors: Pujol David , Wu Yikai , Fain Brandon , Machanavajjhala Ashwin 
Published: October 2021

Large organizations that collect data about populations (like the US Census Bureau) release summary statistics that are used by multiple stakeholders for resource allocation and policy making problems. These organizations are also legally required to protect the privacy of individuals from whom they collect data. Differential Privacy (DP) provides a solution to release useful summary data while preserving privacy. Most DP mechanisms are designed to answer a single set of queries. In reality, there are often multiple stakeholders that use a given data release and have overlapping but not-identical queries. This introduces a novel joint optimization problem in DP where the privacy budget must be shared among different analysts.
We initiate study into the problem of DP query answering across multiple analysts. To capture the competing goals and priorities of multiple analysts, we formulate three desiderata that any mechanism should satisfy in this setting - The Sharing Incentive, Non-interference, and Adaptivity - while still optimizing for overall error. We demonstrate how existing DP query answering mechanisms in the multi-analyst settings fail to satisfy at least one of the desiderata. We present novel DP algorithms that provably satisfy all our desiderata and empirically show that they incur low error on realistic tasks.
Generating unfavourable VaR scenarios under Solvency II with patchwork copulas
Authors: Pfeifer Dietmar , Ragulina Olena 
Published: October 2021

Abstract
The central idea of the paper is to present a general simple patchwork construction principle for multivariate copulas that create unfavourable VaR (i.e. Value at Risk) scenarios while maintaining given marginal distributions. This is of particular interest for the construction of Internal Models in the insurance industry under Solvency II in the European Union. Besides this, the Delegated Regulation by the European Commission requires all insurance companies under supervision to consider different risk scenarios in their risk management system for the company’s own risk assessment. Since it is unreasonable to assume that the potential worst case scenario will materialize in the company, we think that a modelling of various unfavourable scenarios as described in this paper is likewise appropriate. Our explicit copula approach can be considered as a special case of ordinal sums, which in two dimensions even leads to the technically worst VaR scenario.
Molecular determinants of therapy response of venetoclax-based combinations in acute myeloid leukemia
Authors: Makowka Philipp , Stolp Verena , Stoschek Karoline , Serve Hubert 
Published: October 2021

Abstract
Acute myeloid leukemia (AML) is a heterogeneous, highly malignant disease of the bone marrow. After decades of slow progress, recent years saw a surge of novel agents for its treatment. The most recent advancement is the registration of the Bcl-2 inhibitor ventoclax in combination with a hypomethylating agent (HMA) in the US and Europe for AML patients not eligible for intensive chemotherapy. Treatment of newly diagnosed AML patients with this combination results in remission rates that so far could only be achieved with intensive treatment. However, not all AML patients respond equally well, and some patients relapse early, while other patients experience longer periods of complete remission. A hallmark of AML is its remarkable genetic, molecular and clinical heterogeneity. Here, we review the current knowledge about molecular features of AML that help estimate the probability of response to venetoclax-containing therapies. In contrast to other newly developed AML therapies that target specific recurrent molecular alterations, it seems so far that responses are not specific for a certain subgroup. One exception is spliceosome mutations, where good response has been observed in clinical trials with venetoclax/azacitidine. These mutations are rather associated with a more unfavorable outcome with chemotherapy. In summary, venetoclax in combination with hypomethylating agents represents a significant novel option for AML patients with various molecular aberrations. Mechanisms of primary and secondary resistance seem to overlap with those towards chemotherapy.
An evaluation study of biclusters visualization techniques of gene expression data
Authors: Aouabed Haithem , Elloumi Mourad , Santamaría Rodrigo 
Published: October 2021

Abstract

Biclustering is a non-supervised data mining technique used to analyze gene expression data, it consists to classify subgroups of genes that have similar behavior under subgroups of conditions. The classified genes can have independent behavior under other subgroups of conditions. Discovering such co-expressed genes, called biclusters, can be helpful to find specific biological features such as gene interactions under different circumstances. Compared to clustering, biclustering has two main characteristics: bi-dimensionality which means grouping both genes and conditions simultaneously and overlapping which means allowing genes to be in more than one bicluster at the same time. Biclustering algorithms, which continue to be developed at a constant pace, give as output a large number of overlapping biclusters. Visualizing groups of biclusters is still a non-trivial task due to their overlapping. In this paper, we present the most interesting techniques to visualize groups of biclusters and evaluate them.
Recent advances in bianisotropic boundary conditions: theory, capabilities, realizations, and applications
Authors: Budhu Jordan , Grbic Anthony 
Published: October 2021

Abstract
In recent years, new functionality and unprecedented wavefront control has been enabled by the introduction of bianisotropic metasurfaces. A bianisotropic metasurface is characterized by an electric response, a magnetic response, and an electro-magnetic/magneto-electric response. In general, these metasurfaces consists of an array of metallic or dielectric particles located within a subwavelength thick host medium, and are approximated and modeled as infinitely-thin, idealized sheet boundaries defined along a surface. An appropriate sheet boundary condition which effectively models the tangential field discontinuity due to the array of magnetoelectric inclusions is the Generalized Sheet Transition Condition or GSTC. Several forms of the GSTC appear in literature. Here, we present each interpretation and show how they are related. Synthesis approaches unique to each form are overviewed. By utilizing the GSTC in metasurface design, new possibilities emerge which are not possible with conventional design techniques incorporating only electric or only magnetic responses. Since the metasurfaces are designed using bianisotropic boundary conditions, they must be realized using particles which contain magnetoelectric responses. This review article discusses the design of metasurfaces using the GSTC, and the bianisotropic particles used to realize GSTC’s. Further, it discusses new and recent applications that have emerged due to bianisotropy, and future prospects in metasurface design using bianisotropic boundary conditions. The intent is to provide a comprehensive overview of metasurface design involving bianisotropy and for this review article to serve as a starting point for engineers and scientist that wish to introduce bianisotropy into metasurface design.
Coupled fractional differential systems with random effects in Banach spaces
Authors: Zentar O. , Ziane M. , Khelifa S. 
Published: October 2021

Abstract
The purpose of this work is to investigate
the existence of solutions for a system of random differential equations involving
the Riemann–Liouville fractional derivative.
The existence result is established by means of a random abstract formulation to
Sadovskii’s fixed point theorem principle
[A. Baliki, J. J. Nieto, A. Ouahab and M. L. Sinacer,
Random semilinear system of differential equations with impulses,
Fixed Point Theory Appl. 2017 2017, Paper No. 27]
combined with a technique based on vector-valued metrics and
convergent to zero matrices. An example is also provided to illustrate our result.