bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Forest Inventory For Carbon Reduction In A University City Campus
Authors: Yusoff Safiah Yusmah Muhammad , D Melasutra Md , Hassan Norhaslina 
Published: February 2021

Abstract
Background

Performing forest inventory in the campus is one of the breakthroughs towards achieving sustainable campus. The inventory aims to determine the number of trees and calculate the stocking of carbon and biomass. This is inevitably important when the contribution of trees to the oxygen supplies as well as stocks for carbon biomass are of concern. Realising the importance of contribution of trees to the surrounding community, this study was therefore conducted.
Results

The study area is identified as secondary type forest with 50.1% of the strata is 60–80% canopy cover dominated by small stands. There is a total of 14 sampling plots inventoried and measured using 40 x 40m square plot sampling. 41% of the three species found comprised of rubber trees (Hevea Brasiliensis). The total number of trees estimated is 97,325 trees with the average density of 21 m2/ha and 24,146.54 Mg CO2e aboveground biomass and carbon stocking.
Conclusion

The study has successfully assessed the forest resources that are available in University Malaya campus. It was found that the forests in the study area fall in the category of secondary forest where stands are in the successive growing stages. Intensive sampling units with support from sufficient spatial data produced reliable estimates. This information is crucial for the reporting of forest resources that reside in an urban environment. With the new sets of data of the forest obtained from the forest inventory, UM management now have the ability to easily and accurately evaluate the composition and condition of the forest, and estimate the environmental services and aesthetic values. These are the first few steps that have been taken by UM towards improving the management of the urban forest on campus.
Serum glucose as an important predictor of delayed cerebral ischemia in angiogram-negative subarachnoid hemorrhage
Authors: Zhang Zeyu , Zhang Anke , Wang Xiaoyu , Fang Yuanjian , Liu Yibo , Luo Yujie , Lenahan Cameron , Chen Sheng , Zhang Jianmin 
Published: February 2021

Abstract
Background

Despite benign overall course, angiogram-negative subarachnoid hemorrhage (AN-SAH) still companies with risk of delayed cerebral ischemia (DCI). Serum glucose was previously found to be related to DCI occurrence in aneurysmal subarachnoid hemorrhage (aSAH), but this has not been confirmed in AN-SAH. The aim of this study was to clarify the significance of serum glucose in DCI prediction in AN-SAH patients.
Methods

We included patients with AN-SAH admitted to our hospital between January 2013 and December 2018. According to different bleeding patterns, patients were divided into perimesencephalic AN-SAH (PAN-SAH) and non-perimesencephalic AN-SAH (NPAH-SAH) patients. DCI was defined as symptomatic vasospasm or/and delayed cerebral infarction. A statistical analysis of the clinical, radiological, and laboratory risk factors of DCI was conducted. Logistic regression analysis was performed to identify the independent predictors of DCI.
Results

A total of 244 AN-SAH patients (mean age 55.7 years, 55.7% men) were included with 164 (67.2%) PAN-SAH patients and 80 (32.8%) NPAN-SAH patients. There were significant correlations between high DCI incidence and high serum glucose levels in the first five days after admission in both PAN-SAH patients and NPAN-SAH patients (p < 0.05). High admission serum glucose was significantly related to higher World Federation of Neurosurgeons Scale (WFNS) (p < 0.05). Multivariate logistic regression analysis showed that admission serum glucose (p = 0.001, OR 1.705, 95% CI 1.232–2.360) and WFNS (p = 0.008, OR 2.889, 95% CI 1.322–6.311) were both significant and independent predictors for DCI occurrence in PAN-SAH patients. Admission serum glucose (p = 0.016, OR 2.307, 95% CI 1.167–4.562), standard deviation (SD) of the serum glucose in the first three days after admission (p = 0.049, OR 5.684, 95% CI 1.006–32.114) and modified Fisher scale (mFS) (p = 0.033, OR 1.859, 95% CI 1.051–3.288) were significant and independent predictors for DCI occurrence in NPAN-SAH patients.
Conclusions

Serum glucose is an early biomarker to predict DCI risk in both PAN-SAH and NPAN-SAH patients, which has an important value in guiding intensive care in AN-SAH patients.
Does Meniscectomy Have Any Advantage Over Conservative Treatment of Degenerative Medial Meniscus Posterior Root Tear?
Authors: Lee Nam-Hun , Seo Hyoung-Yeon , Sung Myung-Jin , Na Bo-Ram , Song Eun-Kyoo , Seon Jong-Keun 
Published: February 2021

Abstract
Background: This study aimed to compare the clinical and radiological outcomes of arthroscopic meniscectomy and conservative treatment for degenerative MMPRT.Methods: From January 2007 to December 2014, 146 patients (Meniscectomy group, 90; Conservative group, 56) were evaluated. Clinical outcomes were assessed using the Visual Analog Scale, International Knee Documentation Committee subjective scoring scale, Tegner activity scale, and Lysholm knee scoring scale at the final follow-up. Radiologic outcomes evaluated the progression of osteoarthritis according to the K-L classification. We compared the hip-knee-ankle angle, medial proximal tibial angle, tibial posterior slope angle, and width of medial joint space. After an average follow-up of 6.3 years, the survivorship was analyzed using the Kaplan–Meier method. Results: Although all clinical outcomes had significantly improved in both groups after treatment, the VAS score (p=0.07), IKDC subjective score (p=0.18), Tegner activity scale score (p=0.08), and Lysholm knee score (p=0.53) showed no significant differences between the two groups at the final follow-up. The progression of OA according to the K-L classification, HKAA and width of medial joint space was significantly advanced in the meniscectomy group (p=0.03, 0.04, 0.03, respectively). The 10-year survival rates in the meniscectomy and conservative groups were 87% and 88%, respectively. Conclusions: This study demonstrated that both conservative treatment and meniscectomy provided symptomatic relief. However, it was confirmed that OA progression was more severe in the meniscectomy. We conclude that arthroscopic meniscectomy had no advantage over conservative treatment in terms of clinical outcomes and OA progression.
ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): Perceptions in the Assessment and Treatment of Pubic Rami and Sacral Fragility Fractures Amongst Healthcare Professionals in Geriatric Medicine and Surgery.
Authors: Sahota Opinder , Leighton Paul , Cameron Maribel , Taylor Rachael , Ong Terence , Drummond Avril , Hendrick Paul , Quraishi Nasir , Salem Khalid 
Published: February 2021

Abstract
Background: Pubic rami fragility fractures are common in older people and result in significant morbidity and increased mortality. Co-existing fractures of the sacrum are common, but routinely missed. The aim of the study was to explore the perceptions in the assessment and treatment of pubic rami and sacral fragility fractures amongst healthcare professionals. Methods: We interviewed 14 participants about their experience in the assessment and treatment of patients presenting with pubic rami fragility fractures. Data was analysed using an inductive thematic approach.Results: The majority of patients presenting with a pubic rami fragility fracture were managed by geriatricians. However, many of the geriatricians were not aware that these fractures have a high association with co-existing sacral fragility fractures. Furthermore, they were not aware of the limitations of standard x-ray imaging, nor of the potential benefits of surgical intervention for sacral fragility fractures. Spinal surgeons recommended that early, more specialist imaging in patients with public rami fragility fractures failing to mobilise, would change clinical management, if found to have a coexisting sacral fragility fracture, amenable to surgical intervention. Conclusions: The awareness, assessment and management of sacral fragility fractures in patients presenting with pubic rami fragility fractures is poor amongst healthcare professional in geriatric medicine. Spinal surgeons in this study advocate early further imaging and surgical intervention in patients confirmed to have a concomitant sacral fragility fracture who are failing to mobilise.
PFKP Accelerates Malignant Features in Breast Cancer
Authors: Shibata Masahiro , Inaishi Takahiro , Ichikawa Takahiro , Kanda Mitsuro , Hayashi Masamichi , Soeda Ikumi , Takeuchi Dai , Takano Yuko , Tsunoda Nobuyuki , Kodera Yasuhiro , Kikumori Toyone 
Published: February 2021

Abstract
Purpose The platelet isoform of phosphofructokinase (PFKP) is one of the key enzymes in the glycolytic pathway. PFKP is highly expressed in several cancers, and it has been reported to be involved in the progression of cancer cells. However, its oncological role in breast cancer (BC) remains unclear. This study aimed to evaluate the function of PFKP in BC cells and its expression level in patients with BC.Methods The mRNA and protein expression of PFKP was evaluated in BC and non-cancerous mammary cell lines. Polymerase chain reaction (PCR) array analysis was conducted to evaluate the correlation between PFKP and 84 cancer-related genes. PFKP knockdown was conducted using small interfering RNA, and cell proliferation, invasiveness, and migration were analyzed. Furthermore, the association between PFKP mRNA expression and clinicopathological factors was investigated in 167 patients with BC.Results PFKP was highly expressed in estrogen receptor-negative and human epidermal growth factor receptor 2-negative BC cell lines. PCR array analysis demonstrated that PFKP expression level significantly correlated with that of transforming growth factor beta 1 and MYC proto-oncogene. PFKP knockdown significantly decreased the proliferation and invasiveness of MCF7, SK-BR-3, and MDA-MB-231 cells. Furthermore, cell migration was inhibited in SK-BR-3 and MDA-MB-231 cells. In the clinical specimens, patients with T2/T3/T4, lymph node metastasis, or stage II/III/IV showed higher expression of PFKP mRNA than patients with less severe disease.Conclusions PFKP is involved in promoting tumor-progressive oncological roles in BC cells across different subtypes. PFKP is considered a possible novel therapeutic target for BC.
Optimal vaccine strategy to control COVID-19 pandemic in middle-income countries: Modelling case study of Thailand
Authors: Luangasanatip Nantasit , Pan-Ngum Wirichada , Prawjaeng Juthamas , Saralamba Sompob , White Lisa , Aguas Ricardo , Clapham Hannah , Painter Christopher , Yi Wang , Isaranuwatchai Wanrudee , Teerawattananon Yot 
Published: February 2021

Abstract
Thailand is facing the dilemma of which groups to prioritise for the limited first tranche of vaccinations in 2021. A mathematical modelling analysis was performed to compare the potential short-term impact of allocating the available doses to either the high-risk group (over 65-year-olds) or the high incidence group (aged 20-39). Vaccinating the high incidence group with a vaccine with sufficiently high protection against infection (more than 50%) could provide enough herd effects to delay the expected epidemic peak, resulting in fewer deaths within the 12-month time horizon compared to vaccinating the same number of the high-risk group. After 12 months, if no further vaccination or other interventions were deployed, this strategy would lead to more deaths. With the right vaccine efficacy profile, targeting the high incidence groups could be a viable short-term component of the Thai vaccination strategy. These results and emerging evidence on vaccines and susceptibility suggest prioritisation guidelines should be more nuanced.
Manifestações orais de arboviroses com ênfase em dengue, zika e chikungunya: revisão de literatura
Authors: Oliveira Amanda Alves de , Lacerda Maria Gabriella de Abreu , Barros Ariana Alves de Oliveira , Barreto Jaqueline Oliveira , Cruz José Henrique de Araújo , Freire Julliana Cariry Palhano , Ribeiro Eduardo Dias 
Published: February 2021

Introdução: A dengue, zika e chikungunya são doenças virais que podem ser classificadas como arboviroses. Suas complicações clínicas são de larga escala e podem acometer a cavidade oral. Objetivos: Realizar uma revisão na literatura científica sobre as manifestações clínicas na cavidade oral provocadas pelas arboviroses transmitidas pelo mosquito Aedes Egipty. Metodologia: foram analisados 69 artigos científicos obtidos nas bases de dados PubMed e Scielo correspondentes ao período de 2000 a 2018, tomando por base os seguintes descritores: “dengue”, “zika” e “chikungunya” em associação com o termo “oral manifestation(s)”. Resultados: Nas infecções por dengue clássica os relatos mais frequentes foram manifestações mucocutâneas, vermelhidão e edema nas mucosas, enquanto na dengue hemorrágica o sangramento gengival é tido como mais frequente seguido de focos hemorrágicos pelas demais regiões da mucosa bucal; já a zika mostrou-se presente na saliva, úlceras aftosas, paralisia facial e complicações orais relacionadas à microcefalia; nos casos de infecção pelo vírus chikingunya foram relatados dor, queimação e sangramento na gengiva, incapacidade de deglutir e mastigar, halitose e dor na abertura da boca. Conclusão: Há manifestações orais durante a infecção por Dengue, Zika e Chikungunya demostrando assim, a importância e a necessidade da realização de maiores pesquisas neste campo para instituição de protocolo clínico.
Population Pharmacokinetics of Levetiracetam: A Systematic Review
Authors: Methaneethorn Janthima , Leelakanok Nattawut 
Published: February 2021

Background:
The use of levetiracetam (LEV) has been increasing given its favorable pharmacokinetic profile. Numerous population pharmacokinetic studies for LEV have been conducted. However, there are some discrepancies regarding factors affecting its pharmacokinetic variability. Therefore, this systematic review aimed to summarize significant predictors for LEV pharmacokinetics as well as the need for dosage adjustments.

Methods:
We performed a systematic search for population pharmacokinetic studies of LEV conducted using a nonlinear-mixed effect approach from PubMed, Scopus, CINAHL Complete, and Science Direct databases from their inception to March 2020. Information on study design, model methodologies, significant covariate-parameter relationships, and model evaluation was extracted. The quality of the reported studies was also assessed.

Results:
A total of 16 studies were included in this review. Only two studies were conducted with a two-compartment model, while the rest were performed with a one-compartment structure. Bodyweight and creatinine clearance were the two most frequently identified covariates on LEV clearance (CLLEV). Additionally, postmenstrual age (PMA) or postnatal age (PNA) were significant predictors for CLLEV in neonates. Only three studies externally validated the models. Two studies conducted pharmacodynamic models for LEV with relatively small sample size.

Conclusion:
Significant predictors for LEV pharmacokinetics are highlighted in this review. For future research, a population pharmacokinetic-pharmacodynamic model using a larger sample size should be conducted. From a clinical perspective, the published models should be externally evaluated before clinical implementation.
Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential
Authors: Tuli Hardeep S. , Aggarwal Vaishali , Parashar Gaurav , Aggarwal Diwakar , Parashar Nidarshana C. , Tuorkey Muobarak J. , Varol Mehmet , Sak Katrin , Kumar Manoj , Buttar Harpal S. 
Published: February 2021

Abstract:
The overwhelming globalburden of cancer has posed numerous challenges and opportunities for developing anti-cancer therapies. Phytochemicalshave emerged as promising synergistic compounds with potential anti-cancer effects to supplement chemo- and immune-therapeutic regimens. Anti cancer synergistic effects have been investigated in the interaction between phytocompounds derived from flavonoids such as quercetin, apigenin, kaempferol, hesperidin, emodin etc., and conventional drugs. Xanthohumol is one of the prenylatedphytoflavonoid that has demonstrated key anti-cancer activities in in vitro (anti proliferation of cancer cell lines) and in vivo(animal models of xenograft tumours)studies, and has been explored from different dimensions for targeting cancer subtypes. In the last decade, xanthohumol has been investigated how it induces the anti-cancer effects at cellular and molecular level.The different signalling cascades and targets of xanthohumolare summarized in thisreview.Overall, this reviewsummarizes the current advances made in the field of natural compounds with special reference to xanthohumol and its promising anti-cancer effectsto inhibit tumour progression.The present review hasalso touched upon the potential of xanthohumol transitioning into a lead candidate from nano-therapy viewpoint along with the challenges which need to be addressed for extensive pre-clinical and clinical anti-cancer studies.
Fabrics Recommendation for Fashion Design by Using Fuzzy Logic and
Rough Sets
Authors: Dong Min , Zeng Xianyi , Koehl Ludovic , Zhang Junjie 
Published: February 2021

Background:
Fabric is one of the key and vital design factors in fashion design. However, selection of relevant fabrics is rather complex for designers and managers due to the complexity of criteria at different levels.

Introduction:
In this paper, we propose a new fabric recommendation model in order to quickly realize fabric selection from non-technical fashion features only and predict fashion features from any fabric technical parameters. This approach is extremely significant for fashion designers who do not completely master fabric technical details. It is also very useful for fabric developers who have no knowledge on fashion markets and fashion consumers.

Method:
The proposed fabric recommendation model has been built by exploiting designers’ professional knowledge and consumers’ preferences. Concretely, we first use fuzzy sets for formalizing and interpreting measured technical parameters and linguistic sensory properties of fabrics and then model the relation between the technical parameters and sensory properties by using rough sets. Next, we model the relation between fashion themes and sensory properties using fuzzy relations. By combining these two models, we establish a hybrid model characterizing the relation between fashion themes and technical parameters.

Result:
The proposed model has been validated through a real fabric recommendation case for designer’s specific requirements. We can find that the proposed model is efficient since the averaged value of prediction errors is 8.57%, which does not exceed 10% (generally considered as allowable range of human perception error).

Conclusion:
The proposed model will constitute one important component for establishing an intelligent recommender system for garment design, enabling to support innovations in textile/apparel industry in terms of mass customization and e-shopping.
PRECLINICAL STUDENTS’ PERCEPTION TOWARDS FACTORS OF ACHIEVING MEDICAL COMPETENCE
Authors: Tjahjadinata Christine , Puspadewi Natalia , Rukmini Elisabeth 
Published: February 2021

Background: Based on the existing research, medical competence achievements in DKI Jakarta’s primary health care was lower than other provinces in Indonesia. Some of the competence achievements in preclinical years were also lower than the level of competence achievement in the Standard of Indonesian Doctor Competence, regardless the diseases are at the third and fourth levels. This research aimed at exploring the factors which influenced the competence achievement of the preclinical years based on student’s perceptions.Methods: The research was a descriptive analytic study with a qualitative approach using Focus Group Disscussion (FGD). Nine preclinical students of 2013 batch were chosen purposefully based on the recommendation from faculty members and students. Data were analyzed qualitatively using thematic analysis method.Results: There are several factors that influence the competence achievement of the preclinical students. These included the factors of student, curriculum, faculty, environmental, and facility. There were four participants in the first meeting and five participants in the second meeting.Conclusion: Based on student’s perception, the factors which affect the competence achievements in preclinical years are student factors, curriculum factors, faculty factors, environmental factors, and facility factors. Keywords: competence, medical education, preclinical, qualitative
Perceptions of Robotic Process Automation in Big 4 Public Accounting Firms: Do Firm Leaders and Lower-Level Employees Agree?
Authors: Cooper Lauren A. , Holderness D. Kip , Sorensen Trevor L. , Wood David A. 
Published: February 2021

ABSTRACT
The use of Robotic Process Automation (RPA) is a recent innovation in the public accounting industry, and the Big 4 firms are at the forefront of its implementation. This paper examines how the adoption and use of RPA is affecting the perceived work experience of firm leaders and lower-level employees at Big 4 accounting firms. We interview 14 RPA leaders, survey 139 lower-level employees, and compare and contrast their responses. We find that the two groups generally agree that RPA is having a positive influence on the profession. Both groups believe that RPA is positively changing the work employees perform and improving employee career prospects. However, while firm leaders believe RPA will improve work satisfaction, lower-level employees report no such improvements. Our insights provide direction for the accounting profession as it increases the use of RPA and for future research studies examining related issues.
Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes
Authors: Fukuda Tatsuya , Bouchi Ryotaro , Takeuchi Takato , Amo-Shiinoki Kikuko , Kudo Atsushi , Tanaka Shinji , Tanabe Minoru , Akashi Takumi , Hirayama Kazuhiro , Odamaki Toshitaka , Igarashi Miki , Kimura Ikuo , Tanabe Katsuya , Tanizawa Yukio , Yamada Tetsuya , Ogawa Yoshihiro 
Published: February 2021

OBJECTIVE
To elucidate the pathogenesis of postpancreatectomy diabetes mellitus (PPDM).

RESEARCH DESIGN AND METHODS
Forty-eight patients without diabetes undergoing either pancreatoduodenectomy (PD) (n = 20) or distal pancreatectomy (DP) (n = 28) were included. A 75-g oral glucose tolerance test was performed every 6 months. Microbiome composition and short-chain fatty acids (SCFAs) in feces were examined before and 6 months after surgery. The association of histological characteristics of the resected pancreas with PPDM was examined.

RESULTS
During follow-up (median 3.19 years), 2 of 20 PD patients and 16 of 28 DP patients developed PPDM. Proteobacteria relative abundance, plasma glucagon-like peptide 1 (GLP-1), and fecal butyrate levels increased only after PD. Postsurgical butyrate levels were correlated with postsurgical GLP-1 levels. With no significant difference in the volume of the resected pancreas between the surgical procedures, both β-cell and α-cell areas in the resected pancreas were significantly higher in DP patients than in PD patients. In DP patients, the progressors to diabetes showed preexisting insulin resistance compared with nonprogressors, and both increased α- and β-cell areas were predictors of PPDM. Furthermore, in DP patients, α-cell and β-cell areas were associated with ALDH1A3 expression in islets.

CONCLUSIONS
We postulate that a greater removal of β-cells contributes to the development of PPDM after DP. Islet expansion along with preexisting insulin resistance is associated with high cellular plasticity, which may predict the development of PPDM after DP. In contrast, PD is associated with alterations of gut microbiome and increases in SCFA production and GLP-1 secretion, possibly protecting against PPDM development.