bluuebunny/crossref_metadata_2025_split huggingface dataset:
QTL mapping for bioenergy traits in sweet sorghum recombinant inbred lines
Authors: Souza Vander Fillipe de , Pereira Guilherme da Silva , Pastina Maria Marta , Parrella Rafael Augusto da Costa , Simeone Maria Lúcia Ferreira , Barros Beatriz de Almeida , Noda Roberto Willians , da Costa e Silva Luciano , Magalhães Jurandir Vieira de , Schaffert Robert Eugene , Garcia Antonio Augusto Franco , Damasceno Cynthia Maria Borges 
Published: September 2021

Abstract
During the past decade, sweet sorghum (Sorghum bicolor Moench L.) has shown great potential for bioenergy production, especially biofuels. In this study, 223 recombinant inbred lines (RILs) derived from a cross between two sweet sorghum lines (Brandes × Wray) were evaluated in three trials. Single-nucleotide polymorphisms (SNPs) derived from genotyping by sequencing of 272 RILs were used to build a high-density genetic map comprising 3,767 SNPs spanning 1,368.83 cM. Multitrait multiple interval mapping (MT-MIM) was carried out to map quantitative trait loci (QTL) for eight bioenergy traits. A total of 33 QTLs were identified for flowering time, plant height, total soluble solids and sucrose (five QTLs each), fibers (four QTLs), and fresh biomass yield, juice extraction yield, and reducing sugars (three QTLs each). QTL hotspots were found on chromosomes 1, 3, 6, 9, and 10, in addition to other QTLs detected on chromosomes 4 and 8. We observed that 14 out of the 33 mapped QTLs were found in all three trials. Upon further development and validation in other crosses, the results provided by the present study have a great potential to be used in marker-assisted selection in sorghum breeding programs for biofuel production.
Communication Partner Engagement: A Relevant Factor for Functional Outcomes in Speech–Language Therapy for Aphasic Dementia
Authors: Rogalski Emily , Roberts Angela , Salley Elizabeth , Saxon Marie , Fought Angela , Esparza Marissa , Blaze Erin , Coventry Christina , Mesulam Marek-Marsel , Weintraub Sandra , Mooney Aimee , Khayum Becky , Rademaker Alfred 
Published: September 2021

Abstract

Objectives
Previous reports established the feasibility of a telehealth model for delivering speech–language therapy via Internet videoconferencing, which connects individuals with primary progressive aphasia (PPA) to an expert speech and language pathologist for treatment. This study reports feasibility of the same telehealth intervention in a larger set of progressive aphasia participants and explores factors potentially influencing functional intervention outcomes.

Methods
Participants with PPA or progressive aphasia in the context of a neurodegenerative dementia syndrome and their communication partners were enrolled into an 8-session intervention, with 3 evaluations (baseline, 2 months, and 6 months postenrollment). Half of the participants were randomized into a “check-in” group and received 3-monthly half-hour sessions postintervention. Mixed linear models with post hoc testing and percent change in area under the curve were used to examine communication confidence over time, as well as the influence of check-in sessions and the role of communication partner engagement on communication confidence.

Results
Communication confidence improved at the 2-month evaluation and showed no significant decline at the 6-month evaluation. Item-level analysis revealed gains in communication confidence across multiple communication contexts. Gains and maintenance of communication confidence were only present for the engaged communication partner group and were not bolstered by randomization to the check-in group.

Discussion
Internet-based, person-centered interventions demonstrate promise as a model for delivering speech–language therapy to individuals living with PPA. Maintenance is possible for at least 6 months postenrollment and is better for those with engaged communication partners, which supports the use of dyadic interventions.
Convergence of graph Laplacian with kNN self-tuned kernels
Authors: Cheng Xiuyuan , Wu Hau-Tieng 
Published: September 2021

AbstractKernelized Gram matrix $W$ constructed from data points $\{x_i\}_{i=1}^N$ as $W_{ij}= k_0( \frac{ \| x_i - x_j \|^2} {\sigma ^2} ) $ is widely used in graph-based geometric data analysis and unsupervised learning. An important question is how to choose the kernel bandwidth $\sigma $, and a common practice called self-tuned kernel adaptively sets a $\sigma _i$ at each point $x_i$ by the $k$-nearest neighbor (kNN) distance. When $x_i$s are sampled from a $d$-dimensional manifold embedded in a possibly high-dimensional space, unlike with fixed-bandwidth kernels, theoretical results of graph Laplacian convergence with self-tuned kernels have been incomplete. This paper proves the convergence of graph Laplacian operator $L_N$ to manifold (weighted-)Laplacian for a new family of kNN self-tuned kernels $W^{(\alpha )}_{ij} = k_0( \frac{ \| x_i - x_j \|^2}{ \epsilon \hat{\rho }(x_i) \hat{\rho }(x_j)})/\hat{\rho }(x_i)^\alpha \hat{\rho }(x_j)^\alpha $, where $\hat{\rho }$ is the estimated bandwidth function by kNN and the limiting operator is also parametrized by $\alpha $. When $\alpha = 1$, the limiting operator is the weighted manifold Laplacian $\varDelta _p$. Specifically, we prove the point-wise convergence of $L_N f $ and convergence of the graph Dirichlet form with rates. Our analysis is based on first establishing a $C^0$ consistency for $\hat{\rho }$ which bounds the relative estimation error $|\hat{\rho } - \bar{\rho }|/\bar{\rho }$ uniformly with high probability, where $\bar{\rho } = p^{-1/d}$ and $p$ is the data density function. Our theoretical results reveal the advantage of the self-tuned kernel over the fixed-bandwidth kernel via smaller variance error in low-density regions. In the algorithm, no prior knowledge of $d$ or data density is needed. The theoretical results are supported by numerical experiments on simulated data and hand-written digit image data.
Trade Unions and Platform Workers in the UK: Worker Representation in the Shadow of the Law
Authors: Bertolini Alessio , Dukes Ruth 
Published: September 2021

Abstract
Drawing on a series of interviews with key actors including representatives of the main trade unions, this paper considers the response of unions in the UK to the emergence and growth of platform work. Comparing the partly different strategies adopted by traditional and alternative unions in respect of the representation of platform workers’ interests, it demonstrates that the unions’ choices have been shaped by the characteristics and resources of the unions themselves, by prevailing political conditions and, perhaps above all, by the restrictive legal framework that excludes many platform workers from the scope of employment legislation. Without recourse to either a legally protected freedom to take industrial action or the statutory recognition procedure, unions have only exceptionally been able to negotiate collective agreements on behalf of platform workers. Instead, traditional unions have focussed on broader political strategies to fight precariousness, including wielding an influence on policymaking, especially through their relations with the Labour Party. Alternative unions have channelled resources into organising and mobilising platform workers and supporting them in campaigning, protesting and bringing strategic litigation.
A Sensitive Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry Method Based on Derivatization with 1-Nitro-2-Naphthaldehyde for Determination of Alkylhydrazines in Surface Water
Authors: Oh Jin-Ah , Shin Ho-Sang , Lim Hyun-Hee 
Published: September 2021

AbstractBackgroundAlkylhydrazines are widely used in industrial fields. An analysis of alkylhydrazines in surface water is needed because these chemicals are likely to be discharged into wastewater and enter aquatic environments.ObjectiveAn ultra-high performance liquid chromatography (UHPLC)–tandem mass spectrometry (MS/MS) method was developed to determine the levels of five alkylhydrazines (N, N-dimethylhydrazine, ethylhydrazine, 1-isopropylhydrazine, phenylhydrazine, and 1-methyl-1-phenylhydrazine) in surface water.MethodsThis method is based on the derivatization of alkylhydrazines with 1-nitro-2-naphthaldehyde (NNA) in water. A derivatization reagent dosage of 0.5 mg NNA, a pH of 2, and a reaction time of 30 min at 40°C were determined to be the optimal conditions for UHPLC–MS/MS detection. The derivatives were injected into the LC system without additional extraction or purification steps.ResultsThe proposed method was used under optimized conditions to detect alkylhydrazines in surface water, with the limit of quantification found to be 0.01–0.03 μg/L. The accuracy ranged from 91.0 to 106.0%, and the precision, expressed as the relative standard deviation, was less than 10%. Of the five alkylhydrazines, only N, N-dimethyl hydrazine was detected in the real samples at a concentration range of 0.010–0.041 μg/L.ConclusionThe developed method can be used to confirm the presence of alkylhydrazine residues in surface water and represents an important tool for evaluating the fate of alkylhydrazines in surface water.HighlightsA UHPLC-MSMS method was developed in order to dtermine the alkylhydrazine in surface water after derivatization without an extraction or cleanup step.
Comparing ELISA and LC–MS-MS: A Simple, Targeted Postmortem Blood Screen
Authors: Swanson Dina M , Pearson Julia M , Evans-Nguyen Theresa 
Published: September 2021

Abstract
A comprehensive screening method that is specific, accurate and customizable is necessary in any forensic toxicology laboratory. Most laboratories utilize some form of immunoassay testing as it is reliable and sensitive with minimal sample preparation and is relatively inexpensive to simultaneously screen for multiple classes of drugs with different chemical properties. However, accessibility to more specific technology and instrumentation such as mass spectrometry has increased and therefore using immunoassay as the screening method of choice may be revisited. A screening method for 42 drugs in postmortem blood was developed and validated following the Organization of Scientific Area Committees for Forensic Science guidelines for toxicology method validation. The method was developed using minimal sample preparation of postmortem blood consisting only of a protein precipitation. Only two internal standards were used, which greatly reduces the cost of implementing this method. Limit of detection, interference studies, processed sample stability and ion suppression/enhancement were examined. Additionally, over 100 case samples were analyzed by both the current enzyme-linked immunosorbent assay (ELISA) testing procedure and the proposed liquid chromatography–tandem mass spectrometry (LC–MS-MS) screening method. The comparison determined that the LC–MS-MS method performed as well as or better than the ELISA in nearly all cases. The ability to add additional target drugs increases the laboratory’s scope of analysis as well. This method is ideal for forensic laboratories wishing to improve screening while working within budget constraints.
Circ_0000514 promotes breast cancer progression by regulating the miR-296-5p/CXCL10 axis
Authors: Li Liangping , Feng Gang , Chen Tao , Zhang Lijun 
Published: September 2021

Abstract
The biological function of circular RNA 0000514 (circ_0000514) in breast cancer (bc) is still unknown. In this study, we downloaded the microarray dataset GSE101123 from Gene Expression Omnibus database and then analysed the differentially expressed circular RNAs in bc tissues compared with adjacent tissues, and we demonstrated that circ_0000514 was up-regulated in bc tissues. Circ_0000514, miR-296-5p and CXC chemokine ligand10 (CXCL10) expressions in bc tissues and cell lines were probed by quantitativereal-time polymerase chain reaction and Western blot. Cell counting kit-8, 5-bromo-2′-deoxyuridine and transwell assays were adopted to determine the cell viability, proliferation, migration and invasion. The targeting relationship between miR-296-5p and circ_0000514 or CXCL10 3′-UTR was predicted by bioinformatics and validated by dual-luciferase reporter assay. We demonstrated that circ_0000514 and CXCL10 expressions were raised in bc tissues and cell lines while miR-296-5p expression was declined. Circ_0000514 knockdown could inhibit the proliferation, migration and invasion of bc cells and miR-296-5p overexpression also suppressed the malignant phenotypes of bc cells. Mechanistically, miR-296-5p was identified as the downstream target of circ_0000514 and could be inhibited by circ_0000514. Moreover, CXCL10 was the target of miR-296-5p, whose expression could be indirectly and positively regulated by circ_0000514. In conclusion, circ_0000514 is involved in bc progression via regulating miR-296-5p/CXCL10 axis.
The Impact of Burn Survivor Preinjury Income and Payer Status on Health-Related Quality of Life
Authors: Sheckter Clifford C , Carrougher Gretchen J , Wolf Steven E , Schneider Jeffrey C , Gibran Nicole , Stewart Barclay T 
Published: September 2021

Abstract
The costs required to provide acute care for patients with serious burn injuries are significant. In the United States, these costs are often shared by patients. However, the impacts of preinjury finances on health-related quality of life (HRQL) have been poorly characterized. We hypothesized that lower income and public payers would be associated with poorer HRQL. Burn survivors with complete data for preinjury personal income and payer status were extracted from the longitudinal Burn Model System National Database. HRQL outcomes were measured with VR-12 scores at 6, 12, and 24 months postinjury. VR-12 scores were evaluated using generalized linear models, adjusting for potential confounders (eg, age, sex, self-identified race, burn injury severity). About 453 participants had complete data for income and payer status. More than one third of BMS participants earned less than $25,000/year (36%), 24% earned $25,000 to 49,000/year, 23% earned $50,000 to 99,000/year, 11% earned $100,000 to 149,000/year, 3% earned $150,000 to 199,000/year, and 4% earned more than $200,000/year. VR-12 mental component summary (MCS) and physical component summary (PCS) scores were highest for those who earned $150,000 to 199,000/year (55.8 and 55.8) and lowest for those who earned less than $25,000/year (49.0 and 46.4). After adjusting for demographics, payer, and burn severity, 12-month MCS and PCS and 24-month PCS scores were negatively associated with Medicare payer (P &lt; .05). Low income was not significantly associated with lower VR-12 scores. There was a peaking relationship between HRQL and middle-class income, but this trend was not significant after adjusting for covariates. Public payers, particularly Medicare, were independently associated with poorer HRQL. The findings might be used to identify those at risk of financial toxicity for targeting assistance during rehabilitation.
Social Exchange of Motivated Beliefs
Authors: Oprea Ryan , Yuksel Sevgi 
Published: September 2021

Abstract
We use laboratory experiments to study whether biases in beliefs grow more severe when people socially exchange these beliefs with one another. We elicit subjects’ (naturally biased) beliefs about their relative performance in an intelligence quotient (IQ) test and allow them to update these beliefs in real time. Part of the way through the task we give each subject access to the beliefs of a counterpart who performed similarly on the test and allow them both to observe the evolution of one another’s beliefs. We find that subjects respond to one another’s beliefs in a highly asymmetric way, causing a severe amplification of subjects’ initial bias. We find no such patterns in response to objective public signals or in control treatments without social exchange or scope for motivated beliefs. We also provide evidence that the pattern is difficult to reconcile with Bayesianism and standard versions of confirmation bias. Overall, our results suggest that bias amplification is likely driven by “motivated assignment of accuracy” to others’ beliefs: subjects selectively attribute higher informational value to social signals that reinforce their motivation.
Responses of morphological and physiological traits to herbivory by snails of three invasive and native submerged plants
Authors: Huang Xiaolong , Yu Jinlei , Guan Baohua , Xie Hongmin , Liu Shuailing , He Hu , Li Kuanyi 
Published: September 2021

AbstractThe submerged plant species Carolina fanwort (Cabomba caroliniana) has become a dominant invasive aquatic plant in the Lake Taihu Basin (LTB) in China. Introduced species may escape their original specialist enemies and encounter fewer enemies in their new environment. They were assumed to have suffered less herbivory than native species as they are relatively unpalatable (the enemy release hypothesis [ERH]). The objective of this study was to compare the responses of C. caroliniana with those of co-occurring native species to herbivory from native herbivores. We conducted a mesocosm experiment to record the responses of C. caroliniana and two commonly co-occurring native submerged plant counterparts, water thyme (Hydrilla verticillata) and Eurasian watermilfoil (Myriophyllum spicatum), to herbivory by two native generalist gastropod snails, Radix swinhoei and Sinotaia quadrata. Plant morphological traits (total biomass, shoot/root [S/R] biomass ratio and relative growth rate [RGR]) and physiological traits (leaf total nonstructural carbohydrate [TNC], lignin, and cellulose) were recorded. The snail S. quadrata rarely influenced the plant traits of the three submerged plants. With the increasing numbers of R. swinhoei treatments, most of the plant traits of H. verticillata and M. spicatum changed, while those of C. caroliniana showed a relatively stable fluctuation. This result indicates that C. caroliniana is more resistant to herbivory by the snail R. swinhoei, which is consistent with the ERH hypothesis. This finding indicates that herbivorous snail species contributes to the invasion of C. caroliniana, which potentially alters the species composition of submerged plants in the plant community.
A literature review of pharmacist’s impact on lifestyle modifications among obese, hypertensive patients
Authors: Gonzalez Gonzalez Yaran K , Yaun Kristen , Shah Pooja , Iglesias George , Hale Genevieve Marie , Khanfar Nile M 
Published: September 2021

Abstract

Objectives
Previous trials have confirmed a positive relationship between obesity and hypertension. The purpose of this article is to identify the impact of pharmacists in lifestyle adherence among obese, hypertensive patients.

Methods
A literature search was performed at an academic institution using secondary databases, PubMed/MEDLINE and EBSCOhost. Reviews, observational and experimental reports published in English between 2010 and 2020 were included. Terms searched were pharmacy, pharmacist, lifestyle modifications, adherence, compliance, hypertension, obesity, consultation, intervention. Effect on lifestyle modifications consisted of change in blood pressure values, weight, body mass index, diet/sodium intake and/or exercise.

Key findings
Six hundred seventy-five articles were reviewed with 10 meeting inclusion criteria. The role of a pharmacist has a positive impact on compliance in lifestyle adherence with obese, hypertensive patients. Additionally, age, gender marital status, education, monthly income, knowledge level and beliefs of hypertension and co-morbidities all can affect adherence to lifestyle modifications.

Conclusions
The pharmacist has a vital role in the management of hypertension and obesity through frequent interactions with patients to increase adherence to lifestyle modifications.
Exploring the role of binarity in the origin of the bimodal rotational velocity distribution in stellar clusters
Authors: Kamann Sebastian , Bastian Nate , Usher Christopher , Cabrera-Ziri Ivan , Saracino Sara 
Published: September 2021

ABSTRACT
Many young- and intermediate-age massive stellar clusters host bimodal distributions in the rotation rates of their stellar populations, with a dominant peak of rapidly rotating stars and a secondary peak of slow rotators. The origin of this bimodal rotational distribution is currently debated and two main theories have been put forward in the literature. The first is that all/most stars are born as rapid rotators and that interacting binaries break a fraction of the stars, resulting in two populations. The second is that the rotational distribution is a reflection of the early evolution of pre-main sequence stars, in particular, whether they are able to retain or lose their protoplanetary discs during the first few Myr. Here, we test the binary channel by exploiting multi-epoch Very Large Telescope/MUSE observations of NGC 1850, an ∼100 Myr massive cluster in the Large Magellanic Cloud, to search for differences in the binary fractions of the slow- and fast-rotating populations. If binarity is the cause of the rotational bimodality, we would expect that the slowly rotating population should have a much larger binary fraction than the rapid rotators. However, in our data we detect similar fractions of binary stars in the slow and rapidly rotating populations (5.9 ± 1.1 and 4.5 ± 0.6 per cent, respectively). Hence, we conclude that binarity is not a dominant mechanism in the formation of the observed bimodal rotational distributions.
The causal effect of environment on halo mass and concentration
Authors: Cadiou Corentin , Pontzen Andrew , Peiris Hiranya V , Lucie-Smith Luisa 
Published: September 2021

ABSTRACT
Understanding the impact of environment on the formation and evolution of dark matter haloes and galaxies is a crucial open problem. Studying statistical correlations in large simulated populations sheds some light on these impacts, but the causal effect of an environment on individual objects is harder to pinpoint. Addressing this, we present a new method for resimulating a single dark matter halo in multiple large-scale environments. In the initial conditions, we ‘splice’ (i.e. insert) the Lagrangian region of a halo into different Gaussian random fields, while enforcing consistency with the statistical properties of Lambda cold dark matter. Applying this technique, we demonstrate that the mass of haloes is primarily determined by the density structure inside their Lagrangian patches, while the haloes’ concentration is more strongly affected by environment. The splicing approach will also allow us to study, for example, the impact of the cosmic web on accretion processes and galaxy quenching.
General-relativistic treatment of tidal g-mode resonances in coalescing binaries of neutron stars – II. As triggers for precursor flares of short gamma-ray bursts
Authors: Kuan Hao-Jui , Suvorov Arthur G , Kokkotas Kostas D 
Published: September 2021

ABSTRACT
In some short gamma-ray bursts, precursor flares occurring ∼ seconds prior to the main episode have been observed. These flares may then be associated with the last few cycles of the inspiral when the orbital frequency is a few hundred Hz. During these final cycles, tidal forces can resonantly excite quasi-normal modes in the inspiralling stars, leading to a rapid increase in their amplitude. It has been shown that these modes can exert sufficiently strong strains on to the neutron star crust to instigate yieldings. Due to the typical frequencies of g- modes being ∼100 Hz, their resonances with the orbital frequency match the precursor timings and warrant further investigation. Adopting realistic equations of state and solving the general-relativistic pulsation equations, we study g-mode resonances in coalescing quasi-circular binaries, where we consider various stellar rotation rates, degrees of stratification, and magnetic field structures. We show that for some combination of stellar parameters, the resonantly excited g1 and g2 modes may lead to crustal failure and trigger precursor flares.