bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANÁLISE DA CORRELAÇÃO ENTRE INDEPENDÊNCIA FUNCIONAL E SATISFAÇÃO COM A TECNOLOGIA ASSISTIVA EM PESSOAS COM LESÃO MEDULAR
Authors: Tannús Rogério Assunção , Ordones Eduarda da Rocha , Guerra Débora Mikaelly Calaça da Silva , Orcino Juliane Leite , Melo Rozany Cristina de Souza , Silva Antonio Márcio Teodoro Cordeiro , Almeida Rogério José de 
Published: July 2021

A lesão medular (LM) repercute altamente no nível de incapacidade física. Pessoas com LM que utilizam dispositivo auxiliar de mobilidade tendem a desenvolver maior independência funcional. O objetivo foi avaliar a correlação entre independência funcional em atividades de vida diária e a satisfação com o uso de tecnologia assistiva (cadeira de rodas) em pessoas com lesão medular. Trata-se de um estudo transversal analítico com abordagem quantitativa. A amostra foi de 146 participantes com lesão medular traumática com paraplegia e tetraplegia. Para coleta de dados foram utilizados um questionário sociodemográfico, e as escalas Spinal Cord Independence Measure-Self Reported Version (brSCIM-SR) e o Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST.2.0) que permitiram a investigação. A média de idade foi 37,8 anos, com maioria do sexo masculino (82,9%), solteiros (52,7%), escolaridade média (53,4%), acidente de trânsito (50%), arma de fogo (22,6%). Houve predomínio de lesão completa (58,9%) e paraplegia(65,1%). Na brSCIM-SR a média geral foi de 55,3 (±15,8) no domínio do autocuidado de 14,6 (±5,3), respiração/esfíncter 26,4 (±7,4) e mobilidade de 14,3 (±5,5). Na satisfação com a tecnologia assistiva a pontuação total do QUEST 2.0 foi de 3,64 (±0,77), satisfação com o recurso 3,86 (±0,74) e a prestação de serviços 3,64(±0,77). Identificou-se bom desempenho na média da independência funcional. Além disso, altos níveis de satisfação com a tecnologia assistiva, de forma específica mais com o recurso do que com a prestação de serviços. Não foi encontrada correlação entre a independência funcional e a satisfação do uso de cadeira de rodas.
C-methylation of Organic Substrates: A Comprehensive Overview; Methanol
as a Methylating Agent: A Case of Catalysis Versatility (Part III)#
Authors: Moulay Saad 
Published: July 2021

Abstract:
The present account surveys the results of a myriad of works on the C-methylation of organic
substrates with methanol as an eco-friendly methylating agent. The innumerable reports on this
issue reveal the widespread use of a set of solid catalysts such as molecular sieves, zeolites, metal
phosphates, metal oxides and transition metal complexes to accomplish such methylation. One related
facet was the impact of the numbers of Brønstëd acid sites, Lewis acid sites, and Lewis base sites
present in solid catalysts, such as zeolites, their ratios, and strengths that affect the distribution of the
methylation products and their selectivities. Moreover, specific surface area and porosity of some
solid catalysts, such as zeolites, play additional roles in the overall reaction. Not only do these catalyst
properties influence the methylation outcome, the temperature, space velocity (WHSV, LHSV,
GSHV), weight of catalyst per reactant flow rate (W/F), time of stream (TOS), and methanol/
substrate molar ratio also do. The treated substrates herein discussed were aromatic hydrocarbons
(benzene, biphenyls, naphthalenes, toluene, xylenes), alkenes, phenolics (phenol, cresols, anisole), Nheteroarenes,
carbonyls, alcohols, and nitriles. Methylation of benzene affords not only toluene as the
main product but also polymethylated benzenes (xylenes, pseudocumene, hexamethylenebenzene,
and also ethylbenzene as a side-chain product). Furthermore, toluene is sensitive to the reaction conditions,
giving rise to ring methylation and to side-chain one (ethylbenzene and styrene), besides the
formation of benzene as a disproportionation product. A number of results from the methylation of
phenolic compounds bear witness to the interest of different investigators in this special research.
With respect to these phenolics, concurrent O-methylation inevitably parallels the C-methylation,
and the selectivity of the latter one remains dependent on the above-cited factors; ortho-cresol and
2,6-xylenol have been the main C-ring methylated phenols. Methylation of olefins with methanol
over solid catalysts, leading to higher olefins, is of great interest. The chemistry involved in the
methylation of N-heteroarenes, such as pyridines, indoles, and pyrroles, is significant. Application of
the methylation protocols, using methanol as a reagent and transition of metal complexes as catalysts
to ketones, esters, aldehydes, nitriles, and alcohols, ends up with some important molecules, such as
acrylonitrile (a monomer) and isobutanol (a biofuel).
Using Social Media for Peer-to-Peer Cancer Support: Interviews With Young Adults With Cancer
Authors: Lazard Allison J , Collins Meredith K Reffner , Hedrick Ashley , Varma Tushar , Love Brad , Valle Carmina G , Brooks Erik , Benedict Catherine 
Published: July 2021

Background
Web-based social support can address social isolation and unmet support needs among young adults with cancer (aged 18-39 years). Given that 94% of young adults own and use smartphones, social media can offer personalized, accessible social support among peers with cancer.

Objective
This study aims to examine the specific benefits, downsides, and topics of social support via social media among young adults with cancer.

Methods
We conducted semistructured interviews with young adults with cancer, aged between 18 and 39 years, who were receiving treatment or had completed treatment for cancer.

Results
Most participants (N=45) used general audience platforms (eg, Facebook groups), and some cancer-specific social media (eg, Caring Bridge), to discuss relevant lived experiences for medical information (managing side effects and treatment uncertainty) and navigating life with cancer (parenting and financial issues). Participants valued socializing with other young adults with cancer, making connections outside their personal networks, and being able to validate their emotional and mental health experiences without time and physical constraints. However, using social media for peer support can be an emotional burden, especially when others post disheartening or harassing content, and can heighten privacy concerns, especially when navigating cancer-related stigma.

Conclusions
Social media allows young adults to connect with peers to share and feel validated about their treatment and life concerns. However, barriers exist for receiving support from social media; these could be reduced through content moderation and developing more customizable, potentially cancer-specific social media apps and platforms to enhance one’s ability to find peers and manage groups.
A Novel Digital Pill System for Medication Adherence Measurement and Reporting: Usability Validation Study
Authors: Baumgartner Susan L , Buffkin Jr D Eric , Rukavina Elise , Jones Jason , Weiler Elizabeth , Carnes Tony C 
Published: July 2021

Background
Medication nonadherence is a costly problem that is common in clinical use and clinical trials alike, with significant adverse consequences. Digital pill systems have proved to be effective and safe solutions to the challenges of nonadherence, with documented success in improving adherence and health outcomes.

Objective
The aim of this human factors validation study is to evaluate a novel digital pill system, the ID-Cap System from etectRx, for usability among patient users in a simulated real-world use environment.

Methods
A total of 17 patients with diverse backgrounds who regularly take oral prescription medications were recruited. After training and a period of training decay, the participants were asked to complete 12 patient-use scenarios during which errors or difficulties were logged. The participants were also interviewed about their experiences with the ID-Cap System.

Results
The participants ranged in age from 27 to 74 years (mean 51 years, SD 13.8 years), and they were heterogeneous in other demographic factors as well, such as education level, handedness, and sex. In this human factors validation study, the patient users completed 97.5% (196/201) of the total use scenarios successfully; 75.1% (151/201) were completed without any failures or errors. The participants found the ID-Cap System easy to use, and they were able to accurately and proficiently record ingestion events using the device.

Conclusions
The participants demonstrated the ability to safely and effectively use the ID-Cap System for its intended use. The ID-Cap System has great potential as a useful tool for encouraging medication adherence and can be easily implemented by patient users.
POROUS PLASTIC MATRIX TABLETS OF LEVETIRACETAM FOR ZERO-ORDER CONTROLLED RELEASE: DEVELOPMENT AND FORMULATION OPTIMIZATION
Authors: PARIMI RAVI , VADAPALLI RAMA RAO , PRAVALLIKA K. E. 
Published: July 2021

Objective: The prior objective of the current research work was to develop once-daily levetiracetam extended/controlled-release tablets having zero-order release kinetics with the plastic matrix as the release retarding element. For a high water-soluble drug, the formulation of a dosage form so as to have an extended drug release has always been a difficult task.
Methods: In the current work, levetiracetam which is a highly soluble drug was taken as the model drug for which extended-release matrix tablets were developed using varied plastic polymers like Polyvinyl acetate (PVAc), Polyvinyl chloride (PVC), Eudragit RSPO and Eudragit RLPO. PVP was considered as a pore-forming agent and PEG 6000 was taken as a water regulating agent. The porous plastic matrix tablets were prepared by embedding the drug in solvent-activated polymer dispersion followed by drying, sieving, mixing with other excipients and finally compressed. Including physical characterization studies and drug release studies, the tablets were subjected to SEM studies before and after the dissolution studies to analyze the effect of the pore former.
Results: Pre-compression mixtures exhibited good packageability of 81-92% and hence the compressed tablets were strong enough with good tensile strength in the range of 0.78–0.90 N/mm2. Drug release study results showed that the drug release was controlled for a period of 12–24h. PVAc had shown better controlled-release among all the plastic polymers taken. PEG 6000 in combination with PVP produced the desired zero-order drug release.
Conclusion: The levetiracetam porous plastic matrix tablets were developed with zero-order drug release that was effectively controlled for 24hr.
HPLC ANALYSIS OF AMINO ACIDS CONTENT IN CRAMBE CORDIFOLIA AND CRAMBE KOKTEBELICA LEAVES
Authors: SLOBODIANIUK LIUDMYLA , BUDNIAK LILIIA , MARCHYSHYN SVITLANA , SKRYNCHUK OLHA , KUDRIA VICTORIIA 
Published: July 2021

Objective: The aim of our study was to establish the content of some primary metabolites, such as amino acids in Crambe cordifolia and Crambe koktebelica. The lack of experimental data induced us to determine these compounds.
Methods: Crambe cordifolia and Crambe koktebelica leaves were selected as the objects of the study. The amino acids in the raw materials were determined by the HPLC method.
Results: The results of the research revealed that the leaves of Crambe cordifolia and Crambe koktebelica contain fifteen and sixteen free amino acids respectively. Among the free amino acids L-histidine was presented in Crambe cordifolia leaves in the greatest amount, its content was 12.19 µg/mg. The content of free L-arginine, L-valine, L-phenylalanine, L-isoleucine was the greatest in Crambe koktebelica leaves, it was 2.23 µg/mg, 2.04 µg/mg, 1.74 µg/mg, 1.50 µg/mg respectively. The content of bound L-glutamic acid, Glycine, L-arginine, L-leucine was the highest in Crambe cordifolia and Crambe koktebelica leaves.
Conclusion: The results of the study showed that Crambe cordifolia and Crambe koktebelica can be considered as a source of highly digestible amino acids that can be used to treat some diseases.
FORMULATION DEVELOPMENT AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY SYSTEM BY ZAFIRLUKAST
Authors: KRISHNA N. SHIVA , JAYANTHI B. , MADHUKAR A. 
Published: July 2021

Objective: The main objective of the present study was to formulate and evaluate a time-controlled single-unit oral pulsatile drug delivery system containing Zafirlukast for the prevention of nocturnal asthma attacks. To provide time-scheduled drug release for Asthma disease. It is used for preventing asthmatic attacks at early morning. Pulsatile release dosage form is increasing patient compliance by reducing the dosing frequency, especially in the early morning.
Methods: Core tablets were prepared by incorporating different concentrations of natural and synthetic super disintegrants. Drug-containing core tablets (ZC1-ZC15) with different compositions of natural super disintegrants (Plantago ovata seed powder, Locust bean gum) synthetic super disintegrants (Sodium starch glycolate (SSG), Cross carmellose sodium (CCS), Crospovidone (CP)) were prepared by direct compression technique. The core tablets were subjected to pre-formulation, physicochemical and In vitro drug release studies. The fast disintegrating core tablet formulation was selected and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic polymers Eudragit RS100, Eudragit RL 100, Ethylcellulose and hydrophilic polymers Hydroxypropyl methylcellulose K4M, K100M. The optimized formulation was selected and quantified based on in vitro drug release profile in simulated gastric and intestinal fluids.
Results: The pre and post-compression parameters of tablets were also found to be within limits. Formulation ZC5 with 16 mg of Locust bean gum showed the least disintegrating time, i.e., 22.13 sec, and was selected as the best immediate release core tablet. The press-coated tablet formulation P8 having 62.5 mg Eudragit RS100 and 62.5 mg of HPMC K4M in ratio 1:1 over the core tablet ZC5 showed rapid and drug release nearly after 4 h lag time and 98.86 % up to 12 h. Accelerated stability studies of the optimized formulation P8 indicated no significant difference in release profile after 3 mo.
Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating amount level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.
Clinical fnd epidemiological features of measles by adults in modern period
Authors: Basina V. V. , Esaulenko E. V. , Novak K. E. , Bichurina M. A. , Lyalina L. V. 
Published: July 2021

Positive results have been achieved during the implementation of the measles elimination program in the Russian Federation and in the Northwestern Federal District (NWFD). However, measles remains an urgent problem for some regions due to the peculiarities of this infection.Purpose of the work: to characterize the clinical, epidemiological and molecular genetic characteristics of measles in adults during the period of increasing incidence in St. Petersburg.Materials and methods: the incidence of measles in the Northwestern Federal District was analyzed in 2006–2020, and the data of 30 patients of S.P. Botkin clinical infectious diseases hospital over 18 years old (2018). The diagnosis of measles is confirmed by enzyme immunoassay. Molecular genetic studies (PCR, sequencing) were carried out at the National Scientific and Methodological Center for the Surveillance of Measles and Rubella of G.N. Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, biological material was used (nasopharyngeal washings, urine).Results: there was an increase in morbidity in some regions of the Northwestern Federal District in conditions of high coverage of the population with measles vaccinations. In the age structure in 2018–2019 the proportion of adults was 65%. 74% of patients were not vaccinated against measles. A moderate-severe course (100%) was noted, regardless of the genotypes of the virus. Clinical manifestations were characterized by febrile, catarrhal and exanthema syndrome. Diarrhea was found in 36,7% of patients, hepatomegaly in 43.4%, and an increase in transaminases in 87%. 66,7% of patients traveled outside St. Petersburg. The genotypes of the virus were identified: B3 Kabul and B3 Dublin of African origin, D8 Girsomnath of Indian origin.Conclusions: measles remains an urgent problem, in recent years, adults prevail among patients, both local and imported cases are recorded. The clinical course of the disease may be accompanied by intestinal complications and other symptoms that make it difficult to diagnose at the prehospital stage. The use of molecular genetic methods makes it possible to identify the pathogen, assess the identity of viral isolates, and improve the epidemiological surveillance of the infection.
Assessment of the timeliness of vaccination against pertussis in children of the first year of life and the reasons for the violation of the vaccination schedule
Authors: Chernova T. M. , Timchenko V. N. , Pedash A. I. , Subbotina M. D. , Bulina O. I. , Ermakova E. O. , Uskova S. Yu. 
Published: July 2021

The maximum incidence of pertussis in young children confirms the importance of their timely immunization.The goal is – to study the timeliness of vaccination against whooping cough, causes of violation of the vaccination schedule in young children, the effect of recombinant interferon-a on the post-vaccination period.Materials and methods: the vaccination history and data on the course of the post-vaccination period after immunization with DPT and DaPT vaccines of 469 children at the age of 3–24 months were studied.Results. The analysis showed that 14,9% of the observed children were not vaccinated against whooping cough in a timely manner. Of these: 34,3% had a written refusal to vaccinate (5.1% of the total number of observed children), in 32,8% of cases, the vaccination schedule was violated due to late arrival of parents, 32,9% of children by the start of immunization had medical challenges, and only half of them had justified contraindications. Non-serious side effects associated with immunization were observed in 11.3% of cases, statistically more often with DTP (22,0%) compared with DaPT (5.,5%). General and local reactions, in general, were recorded on DPT (6,9% and 15,1%, respectively) and less often developed with the use of DaPT (1,0% and 4,5%, respectively). Within 1 month after immunization, 16,2% of the observed children had an acute respiratory viral infection of varying severity. Those who did not receive antiviral therapy more often carried the disease in a moderate and severe form, which in all cases led to the postponement of the administration of the second and third doses of the vaccine.Conclusion. To increase the timeliness of vaccination of children against whooping cough, medical professionals should persistently remind parents about the timing of turnout for the next vaccination, when making medical withdrawals, be guided by modern methodological documents and instructions for vaccines. The use of antiviral and immunomodulatory effects of IFN-alpha drugs allows us to comply with the recommended schedule for vaccination of children with a high risk of SARS in the post-vaccination period.
Pengujian Theory of Planned Behavior Dalam Memprediksi Niat Polisi Menggunakan Sitem Penilaian Kinerja Online Pada Polsek Seririt Kabupaten Buleleng
Authors: Cantika Kadek Gayatri Dwi , Suci Ni Made 
Published: July 2021

This study aimed to clarify the effect of Theory of Planned Behavior on the intentions use an online performance evaluation system (SPK). This research used a causal quantitative design. 40 police officers aged 30 years and a minimum working period of 10 years were involved in this research. Data were collected used questionnaire method and analyzed using multiple linear regression analysis. The results showed that there were positive and significant influences from (1) attitudes toward intentions using online SPK, (2) subjective norms on intentions using online SPK, (3) perceived behavior control on intentions using SPK and (4) attitudes, subjective norms and perceived behavior control of intentions using online SPK. This means that if want to increase intention to use SPK online, then the commander must ensure that members have a positive attitude, support each member to understand each other and teach and control themselves in using the SPK online.
Efektivitas Model Pembelajaran Discovery Learning Dengan Media Powerpoint Terhadap Hasil Belajar IPA Siswa SD
Authors: Astiti Ni Komang Atik , Rini Kristiantari Maria Goreti , Saputra Ketut Alit 
Published: July 2021

Penelitian ini dilakukan karena hasil belajar IPA siswa kelas VI belum optimal. Hal ini disebabkan oleh pembelajaran yang dilaksanakan guru belum menggunakan model inovatif serta media pembelajaran yang dapat menumbuhkan antusias siswa dalam belajar. Penelitian ini bertujuan untuk meningkatkan hasil belajar IPA melalui penerapan model pembelajaran discovery learning berbantuan media powerpoint. Jenis penelitian yang digunakan adalah penelitian tindakan kelas. Subjek penelitian adalah siswa kelas VI sebanyak 33 orang. Pengumpulan data menggunakan metode tes berbentuk pilihan ganda dengan jumlah soal sebanyak 20 butir. Data hasil belajar dianalisis dengan teknik deskriptif kuantitatif yaitu dengan mencari rata-rata nilai siswa dan ketuntasan belajar. Hasil penelitian menunjukan pada siklus I rata-rata nilai hasil belajar mencapai 67,57 ketuntasan belajar mencapai 66,66% dengan kriteria cukup dan pada siklus II mengalami peningkatan rata-rata nilai hasil belajar mencapai 79,84 dan ketuntasan belajar mencapai 87,87% dengan kriteria tinggi. Dapat disimpulkan adanya meningkatkan hasil belajar IPA siswa kelas VI melalui penerapan model pembelajaran discovery learning berbantuan media powerpoint.
Pengembangan Aplikasi Pembelajaran Matematika Berorientasi Teori Belajar Ausubel Materi KPK dan FPB
Authors: Utami Ni Putu Sri , Agustika Gusti Ngurah Sastra 
Published: July 2021

Penelitian pengembangan ini dilaksanakan berdasarkan kesulitan guru dalam mengembangkan media pembelajaran dimasa pandemi Covid-19. Penelitian ini bertujuan untuk mendeskripsikan rancang bangun, serta mengetahui validitas media aplikasi pembelajaran matematika berorientasi teori belajar ausubel materi KPK dan FPB. Penelitian ini merupakan penelitian pengembangan dengan menggunakan model ADDIE. Subjek penelitian yang digunakan yaitu para ahli dan siswa. Data yang dikumpulkan adalah data kuantitatif. Pengumpulan data menggunakan metode non tes dengan instrument berupa kuesioner/angket. Analisis data yang digunakan yaitu analisis deskriptif kuantitatif. Hasil penelitian pengembangan ini berupa rancang bangun media aplikasi pembelajaran matematika berorientasi teori belajar ausubel materi KPK dan FPB dibuat berdasarkan tahapan model ADDIE yang terdiri dari (a) tahap Analyze, (b) tahap Design, (c) tahap Development, (d) tahap Implementation, (e) tahap Evaluation. Media aplikasi pembelajaran matematika berorientasi teori belajar ausubel materi KPK dan FPB dikatakan layak didasari oleh penilaian yang dilakukan oleh para ahli dan siswa. Hasil penilaian ahli isi mata pelajaran sebesar 86,36% dengan kualifikasi baik, hasil penilaian ahli desain pembelajaran sebesar 93,75% dengan kualifikasi sangat baik, hasil penilaian ahli media pembelajaran sebesar 91,66% dengan kualifikasi sangat baik, hasil uji coba perorangan sebesar 93,70% dengan kualifikasi sangat baik, dan hasil uji coba kelompok kecil sebesar 92,86% dengan kualifiikasi sangat baik. Berdasarkan hasil yang diperoleh, dapat disimpulkan aplikasi pembelajaran matematika berorientasi teori belajar ausubel materi KPK dan FPB layak digunakan.