bluuebunny/crossref_metadata_2025_split huggingface dataset:
Azacitidine Treatment in Patients with Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia Type 2 and Acute Myeloid Leukemia According to their Cytogenetic Findings
Authors: Nikolova D. , Yordanov A. , Radinov A. 
Published: October 2021

Abstract

Introduction: Azacitidine is one of the hypomethylating agents available for the treatment of elderly patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). It is also used as an appropriate treatment of chronic myelomonocytic leukemia (CMML) in the real life setting. As treatment of AML and CMML is not curative, and allogeneic stem cell transplantation (allo-SCT) remains traditionally the only option, significant clinical benefits by hypomethylating agents have been reported. According to the available data, 16% of subjects with MDS who received azacitidine had a complete or partial normalization of blood cell counts and bone marrow morphology, while two-thirds of patients who required blood transfusions no longer needed them. Nevertheless, it can also be hepatotoxic in patients with severe liver impairment and extensive liver tumors.

Aim: to summarize the effect of azacitidine treatment in patients in the light of their general condition, blood count parameters, toxicity (general and hematologic), as well as the presence of cytogenetic aberrations.

Materials and Methods: Twenty-seven patients of which 15 patients with MDS, 9 patients with CMML and 3 patients with AML received azacitidine treatment. The blood count levels and toxicity were followed for a period of twelve months.

Results: 22.2% of our patients (6 of 27) of different hematologic diagnoses showed genetic aberrations in their DNA. All they showed quick disease progression and fatal outcome, four of them also developed hematologic toxicity. The remaining 77.8% had no cytogenetic findings. Of all the cohort, 19.05% developed toxicity during the course of the treatment, 38% – decreased leucocyte levels, 14.3% – decreased thrombocyte levels and 18.2% – decreased hemoglobin level. The erythrocyte levels were not substantially influenced by the treatment. The majority of the patients sustained stable levels of red blood cells, as well as of platelets and hemoglobin without remarkable changes between month 0 and month 6 of the treatment.

Conclusion: Our results showed, that the main disadvantage of azacitidine treatment in our patients were progressive leucopenia (in 10/27 patients or 37% of cases) and toxicity (8/27 or 29.6% of cases).
Application and risk assessment of the energy performance contracting model in energy conservation of public buildings
Authors: Li Hongyan 
Published: October 2021

Abstract
With the development of China’s economy, the total area of public buildings is continuously increasing, and higher energy consumption in this field is gradually becoming prominent. In order to improve this situation, China has been working on energy savings in public buildings since 2007. Energy-saving models and energy policies have become the lifeline of sustainable energy development. Furthermore, the energy-saving renovation of public buildings, as a key project, has attracted the attention of governments and scholars. In the report of the 18th National Congress of the Communist Party of China, energy conservation and emission reduction were given a prominent place. The 13th Five-Year Plan (2016-2020) aims to further promote China’s energy conservation work. On the one hand, administrative and legal measures should be taken to strengthen energy conservation. On the other hand, it is necessary to speed up the establishment of a long-term market-based energy-saving mechanism and to rely on market forces to remove various obstacles to energy conservation. Energy performance contracting (EPC) is a practical and effective method applied in energy conservation. Therefore, this research aims to put forward a relatively perfect energy-saving risk management system for EPC public building projects based on analysis of the factors influencing investment risks of energy-saving projects and the use of quantifiable risk management models, thus providing some theoretical support for the risk decision-making of energy service companies.
Health status diagnosis of the bridges based on multi-fractal de-trend fluctuation analysis
Authors: Zhao Ling , Li Pan , Liu Haiming 
Published: October 2021

AbstractMore and more attention has been paid to the research on bridge structure health monitoring and state analysis technology, especially the theory and technology of time series analysis based on bridge deflection information. In this paper, multi-fractal de-trend analysis (MF-DFA) is used to analysis the deflection information of bridges. The deformation characteristic parameters can be obtained by the multi-fractal de-trend fluctuation method, which can effectively identify the deformation degree of bridges. The analysis result shows that the multi-fractal de-trend fluctuation analysis method provides the theoretical basis and implementation approach for the health monitoring of the bridge.
Uncertainty of Thermographic Temperature Measurement with an Additional close-up Lens
Authors: Dziarski Krzysztof , Hulewicz Arkadiusz 
Published: October 2021

Abstract
The thermographic temperature measurement is burdened with uncertainty. This non-contact temperature measurement method makes it possible to measure the temperature of the electrical device under load. When the observed object is small (a few square millimeters) the spatial resolution of the thermographic cameras is often insufficient. In this case, the use of the additional macro lens is needed. After using an additional lens, the uncertainty of the thermographic measurement is different from the uncertainty of thermographic measurement without an additional lens. The values of the uncertainty contributions depend on the conditions during the measurement and the used methodology. The authors constructed an uncertainty budget of thermographic temperature measurement with an additional macro lens, based on EA-4/02 (European Accreditation publications). The uncertainty contributions were also calculated. On the basis of the calculated values of the uncertainty contributions, it was determined which factor had the greatest impact on the value of the thermographic temperature measurement with an additional lens.
Heidegger and the Overcoming of His Transcendental Understanding of the “World”: from “Entschlossenheit” to “Gelassenheit”
Authors: Mortiaux Dominique 
Published: October 2021

Abstract
This paper presents a paragraph of my thesis whose guiding thread is the theme of language in Heidegger, and which advances two basic claims: 1) Being and Time is an unfinished book and it is thus in the understanding of the planetary achievement of “nihilism” – i.e., of “technique” – that this work from 1927 assumes its whole meaning; and 2) that said, Heidegger’s work, taken as a whole, is a cohesive work that aims at overcoming “nihilism” understood originarily as “forgetfulness of being”. This overcoming is therefore achieved in two stages: 1) the understanding of the phenomenon of “being” arising from the transcendental understanding of the “world”; and 2) the overcoming of that transcendental understanding of the “world” in the full understanding of the phenomenon of “being” as “history,” a process in which the dialogue with poetry will prove to be decisive. This paper emphasizes one aspect of that evolution of Heidegger’s thought “in dialogue with Heidegger,” showing how the understanding of “Ereignis” allows us to conciliate the understanding of the concept of “Entschlossenheit,” presented in Being and Time, with the concept of “Gelassenheit,” that is central in the second stage of Heidegger’s work.
Potocki-Lupski Syndrome Dup17p11.2 in a Girl with Hypotonia and Early Behavioural Disturbances
Authors: Stomnaroska Orhideja , Neskovska Lidija 
Published: October 2021

Abstract
Potocki-Lupski syndrome (PTLS) is a contiguous gene syndrome caused by duplication of chromosome 17p11.2. PTLS is characterized by hypotonia, failure to thrive, congenital anomalies (particularly of the cardiovascular system), intellectual disability, and behavioural disturbances.
The patient was a full-term baby girl, 2,750 grams at birth, delivered via an uncomplicated vaginal delivery with pronounced hypotonia at birth. Nevertheless, there was failure to thrive (weight 7.6 kg; 2.8 SD). Micrognathia, epicanthal skin folds, and megalocornea were noticeable. There was a harsh continuous systolic murmur, and the ultrasound of the heart revealed a persistent arteriosus duct which was surgically closed. At the age of 18 months, the girl could not sit without support, and she could not utter simple words. The girl is often moody, angry, and aggressive. She is hyperactive and unable to establish contacts with family members. A 17p12-p11.2 microduplication was identified via MLPA.
Muscle hypotonia, congenital heart malformation, failure to thrive, developmental delay, behavioural disturbances (or autism spectrum disorder), and intellectual disability are early signs of PTLS. The presence of PTLS was proven by an MLPA analysis.
Diabetes mellitus tipo 2 e a suscetibilidade de infecção por mycobacterium tuberculosis: apresentação das doenças, resposta e tratamento
Authors: Barbosa Raissa Freitas , Costa Fernanda Farias , Silva Karen Vitória Lima , Dutra Vitória Estefany Carvalho , Sousa Natália Carvalho , Sousa Esdras Welesson Matias de , Mota Samyra Gomes , Oliveira Fabíola Santos Lima de , Pereira Domingos Magno Santos , Figueiredo Cristiane Santos Silva e Silva 
Published: October 2021

Objetivo: Descrever a suscetibilidade de indivíduos com Diabetes tipo 2 (DM2) desenvolverem tuberculose pulmonar ativa, assim como apresentar as doenças, diagnóstico e tratamento. Revisão bibliográfica: Há alguns anos, notou-se a associação entre DM2 e infecções oportunistas causadas por micobactérias, com ênfase no Mycobacterium tuberculosis. Considerando que as duas patologias têm alto índice de mortalidade, a associação entre ambas, causa atemorização à saúde pública. De fato, tal associação leva a piores prognósticos quando comparado somente a indivíduos acometidos pelo DM2. A hiperglicemia traz sérios riscos à saúde dos portadores de DM2, com relatos de que portadores de DM2 têm piores desfechos da tuberculose ativa pelo fato do diagnóstico tardio, mau controle da glicemia, e deficiências no sistema imune ocasionadas pela hiperglicemia o que levam a um tratamento mais conflitante ocasionando maior número de óbitos. Considerações finais: Esta revisão apresenta os fatores que influenciam o acometimento e desenvolvimento de tuberculose pulmonar ativa em indivíduos com DM2, e como se dá o diagnóstico e o melhor tratamento estabelecido até os dias atuais.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE PROBING-PROMPTING TERHADAP HASIL BELAJAR IPA SISWA KELAS VIII H SMP NEGERI 30 SEMARANG TAHUN AJARAN 2020/2021
Authors: Munjani Munjani 
Published: October 2021

Pembelajaran secara daring memberikan dampak terhadap proses belajar mengajar sekolahan. Guru berupaya tetap melaksanakan pembelajaran dengan tujuan siswa memperoleh nilai yang optimal. Penggunaan model pembelajaran baru menjadi alternatif yang potensial dalam rangka meningkatkan hasil belajar siswa. Metode pembelajaran yang bisa digunakan salah satunya adalah pembelajaran kooperatif tipe probing-prompting, yaitu pembelajaran yang lebih menekankan respon dan rangsangan terhadap pertanyaan. Kelas VIII SMP Negeri 30 Semarang dipilih sebagai populasi penelitian, dengan sampel kelas VIIIG dan VIIIH. Dengan permasalahan yang ada, penelitian ini berusaha mengidentifikasi pengaruh penerapan model pembelajaran kooperatif tipe probing-prompting terhadap hasil belajar siswa, seberapa besar dan baikkah pengaruh yang diberikan. Pendekatan penelitian dilakukan secara kuantitatif. Dari hasil uji- dua sampel independen, diketahui (). Sehingga, dapat disimpulkan bahwa terdapat perbedaan hasil belajar antara kelas kontrol dengan kelas eksperimen (metode pembelajaran kooperatif tipe probing-prompting). Berdasarkan nilai koefisien Effect Size Cohen sebesar , menunjukkan bahwa pembelajaran kooperatif tipe probing-prompting pada kelas VIIIH di SMP Negeri 30 Semarang memberikan pengaruh yang besar terhadap hasil belajar siswa. Hasil belajar siswa kelas eksperimen mendapat capaian yang lebih tinggi (76,25) dibandingkan kelas kontrol (71,38). Dengan demikian, dapat diketahui bahwa pembelajaran kooperatif tipe probing-prompting menyebabkan siswa memperoleh hasil belajar yang lebih baik dibandingkan pembelajaran konvensional.
Sosialisasi Penangulangan Sampah Melalui Pendekatan Zero Waste di Kawasan Wisata Savana Propok Lombok Timur
Authors: Mertha I Gde , Rizkiawan Handre , Satriadi Ari , Waskito Pandu Susilo 
Published: October 2021

Savana Propok merupakan salah satu destinasi wisata yang berada pada area pegunungan di kawasan Rinjani yang dikelola sebagai objek wisata oleh masyarakat sekitar yang tergabung dalam Kelompok Sadar Wisata (Pokdarwis). Untuk menjaga wisata tersebut tetap terjaga kelestarian alamnya dari pencemaran akibat sampah yang dibawa wisatawan, maka perlu diadakan sosialisasi zero waste. Tujuan sosialisasi yaitu untuk memberikan kesadaran dan pemahaman akan pentingnya menjaga kebersihan kawasan wisata baik di area hutan, jalur pendakian,maupun di area Savana Propok tempat camping. Metode yang digunakan untuk sosialisasi zero waste kepada wisatawan yaitu dengan direct selling dan face to face. Setiap kelompok wisatawan diberikan penjelasan pada saat mendaki agar tidak membawa makanan dan minuman yang berpotensi menjadi sampah dan membawa turun sampah bawaannya. Untuk memastikan program zero waste ini berjalan, pada hari-hari berikutnya dilakukan pemantauan dan pendataan dengan memeriksa barang bawaan dari beberapa kelompok wisataran yang telah diberikan sosialisasi untuk memastikan materi yang telah disosialisasikan dapat diterima atau diterapkan oleh wisatawan yang akan kembali ke Savana Propok. Berdasarkan hasil pengamatan dan pendataan dapat ditarik kesimpulan: (1) Penanggulangan sampah melalui sosialisasi zero waste secara intensif dan monitoring di kawasan wisata Savana Propok berhasil membina wisatawan untuk tetap menjaga kebersihan dan kelestarian alam dengan tidak membuang sampah sembarangan dan kesadaran untuk kembali membawa sampah turun gunung; (2) Sosialisasi melalui pendekatan zero waste berhasil mempengaruhi pola pikir wisatawan terhadap sampah dengan merubah gaya hidup konsumtif dengan menolak penggunaan logistik sekali pakai yang berpotensi menjadi sampah. Kata Kunci: Zero waste; sosialisasi; sampah; savana propok.
Upaya Meningkatkan Minat Belajar Siswa di Masa Pandemi Covid-19 Melalui Pembelajaran Door to Door di Kelurahan Kendo Kecamatan Raba Kota Bima
Authors: Mahrus Mahrus , Ainun Moh. Nurul , Taufikurahman Taufikurahman , Safrillah Arif , Ramadan Elsa Firda , Ayuningtias Wiranting 
Published: October 2021

Selama masa pandemi Covid-19 sekolah-sekolah ditutup sehingga tidak memungkinkan kegiatan belajar mengajar berlangsung secara normal. Kota Bima, Provinsi Nusa Tenggara Barat (NTB) merupakan wilayah yang berzona merah, sehingga pembelajaran yang biasanya dilakukan secara tatap muka di sekolah dialihkan menjadi pembelajaran daring (online). Pelaksanaan pembelajaran daring di Kelurahan Kendo Kecamatan Raba Kota Bima tidak berjalan lancar karena mengalami gangguan jaringan internet di beberapa lokasi. Dampak dari tidak stabilnya jaringan internet sebagai pendukung pembelajaran daring di masa Pandemi Covid-19 adalah minat belajar siswa rendah. Untuk itu, mahasiswa Kuliah Kerja Nyata (KKN) Terpadu Universitas Mataram memilih lokasi tersebut untuk melaksanakan program kegiatan KKN selama dari tanggal 1 Desember 2020 sampai 11 januari 2021 dengan tema “Mengajar di desa dengan menggunakan metode pembelajaran door to door”. Program kegiatan KKN ini bertujuan untuk meningkatkan minat belajar siswa di masa pandemi Covid-19 melalui pembelajaran menggunakan metode door to door. Pelaksanaan kegiatan ini terdiri dari 3 tahapan yaitu tahap persiapan, tahap pelaksanaan, dan evaluasi. Hasil kegiatan menunjukkan bahwa pembelajaran menggunakan metode door to door di masa pandemi Covid-19 ini dapat meningkatkan minat dan hasil belajar siswa di Kelurahan Kendo Kecamatan Raba Kota Bima.
Penyuluhan Tentang Usaha Perbaikan Gizi Keluarga (UPGK) Melalui Pemanfaatan Pekarangan dimasa Pandemi Covid 19
Authors: Kusmiyati Kusmiyati , Rasmi Dewa Ayu Citra , Khairuddin Khairuddin , Sedijani Prapti , Handayani Baiq Sri 
Published: October 2021

Pandemi Covid 19 sudah berlangsung dari bulan Maret 2020, sejak itu berbagai aktivitas yang dilakukan masyarakat biasanya terkait dengan menjaga agar imunitas tubuh tetap terjaga. Menjaga imunitas tubuh tidak terlepas dari pemenuhan gizi sehari-hari. Usaha Perbaikan Gizi Keluarga (UPGK) merupakan sebuah usaha untuk melakukan kegiatan terpadu, bertujuan untuk menanggulangi kekurangan gizi atau untuk memperbaiki gizi masyarakat. Tujuan dari pengabdian ini adalah mengajak mahasiswa agar mau memanfaatkan pekarangan untuk perbaikan gizi keluarga. Kegiatan pengabdian ini dilaksanakan dengan beberapa tahap, yaitu tahap persiapan, tahap observasi, tahap pelaksanaan kegiatan dan tahap pelaporan. Metode yang digunakan meliputi: (a) Metode ceramah, digunakan untuk menyampaikan materi usaha perbaikan gizi keluarga melalui pemanfaatan pekarangan di masa pandemi covid 19. (b). Metode tanya jawab, digunakan untuk memberikan umpan balik pada peserta sekaligus untuk mendapatkan tanggapan peserta tentang materi yang telah disampaikan selama kegiatan. Selain itu, untuk evaluasi kegiatan pengabdian ini dilakukan pretes dan postes. Hasil pengabdian menunjukkan bahwa antusias mahasiswa pada saat pelaksanaan kegiatan sangat tinggi, terlihat mahasiswa mengikuti dari awal hingga akhir, pada waktu dilakukan pretes dan postes, mahasiswa mengirim kembali jawaban pertanyaan melalui google form. Selanjutnya ketika penyampaian materi, mahasiswa juga dapat diajak interaksi, dengan mengajukan pertanyaan dari materi yang disampaikan. Hasil penghitungan gain ternormalisasi sebesar 0,53. Kesimpulan dari kegiatan pengabdian ini adalah: a). Pengetahuan mahasiswa tentang UPGK dan pemanfaatan pekarangan meningkat, dalam kategori sedang; b). Pemanfaatan pekarangan perlu ditata dengan mengedepankan keberagaman spesies untuk kebutuhan dapur, sehingga dapat memenuhi kebutuhan gizi dan memperbaiki gizi keluarga di masa pandemi covid 19.
Pendidikan dan Latihan Menghitung Validitas, Reliabilitas, Tingkat Kesukaran, Daya Beda Soal Bagi Guru PPKn SMAN Se-Kota Mataram
Authors: Fauzan Ahmad , Hariyanto Hariyanto , Rispawati Rispawati , Tripayana I Nengah Agus 
Published: October 2021

Tujuan pengabdian dilakukan ini adalah; 1) meningkatkan kemampuan menghitung validitas, realibilitas , tingkat kesulitan dan daya beda suatu soal bagi guru PPKn pada jenjang SMAN se kota mataram. 2) para guru PPKn jenjang SMAN se Kota mataram menyadari bahwa soal yang telah dihitung validitas, realibilitas, tingkat kesulitan dan daya bedanya, maka mereka telah memiliki soal terstandar. 3) para guru PPKn jenjang SMAN se kota mataram merintis dan membangun Bank soal terstandar dan bank sola PPKn.4) para guru PPKn jenjang SMAN se Kota Mataram memiliki kesadaran untuk memperbaiki soal yang memiliki validitas, realibilitas, tingkat kesukaran dan daya beda yang jelek. Metode pengabdian menggunakan pendekatan studi kasus pengalaman guru terkait dengan soal uraian maupun soal pilihan ganda. Hasil dilakukannya pengabdian ini adalah tidak semua guru suka hitungan statistic, maka banyak guru hanya mengandalkan validitas dan reliabilitas soal secara rasional saja dengan tukar pikiran di antara guru PPKn dalam wadah Musyawarah Guru Mata Pelajaran PPKn. Dengan disediakan materi pengabdian kepada masyarakat secara rinci renik, maka kegiatan Pendidikan Dan Latihan menghitung Tingkat Kesuliatan dan Daya Beda soal disertai contoh menghitung validitas dengan uji product moment dan uji reliabilitas test-retest dengan uji product moment menjadi sangat menarik dan menjadi tantangan tersendri bagi masing-masing peserta.
Faktor-Faktor Yang Mempengaruhi Kesuksesan Implementasi Sistem Informasi Studi Kasus Sistem Informasi Akademik (SIAKAD) STKIP Muhammadiyah Pringsewu Lampung
Authors: Hartono Susilo 
Published: October 2021

This research used the success model of information system from Delone and Mc. Lean which has been modified based on the need and the situation at STKIP Muhammadiyah Pringsewu. The respondents were the first year students in the academic year 2012-2013 and the operators of SIAKAD. The number of the respondents were 196 students and 10 operators. The process of validity and reliability and the hyphotesa used Structural Equation Modeling (SEM). Which is analysed using Amos 20 software.The result of this research showed that from 5 hyphotesis which have been formulated, four of them were received. These hypothesis are the following : the quality of information influence the satisfying of the user ; the quality of the system influence the satisfying of the user; the trust influence the satisfying of the user; and the satisfying of the user influence the benefits of the SIAKAD. On the other hard, the quality of the service doesn’t has significant influence to the satisfying of the SIAKAD user. The success factors, which were resulted in this research, will be used as the suggestion and recomendation in the next SIAKAD development so that the sevice quality of SIAKAD to the students will increase. Keywords: Information Systems Success, DeLone and McLean Model, Structural Equation Modeling (SEM), Analysis of Moment Structures (AMOS).
Expert System Aplikasi Monitoring dan Pengendalian Gizi Berbasis Android
Authors: Gimnastiar Giri , Syuhardi Yossi Indrawati , Vandini Intan 
Published: October 2021

Penelitian ini bertujuan untuk menghasilkan aplikasi sistem pakar berbasis android yang diterapkan pada perangkat mobile serta dapat mendiagnosa penyakit gizi, membantu proses monitoring gizi dan penyembuhannya secara tepat, penelitian ini berfokus juga pada penyelesaian masalah yang berhubungan dengan masalah gizi. Metode pengembangan perangkat lunak untuk expert system monitoring dan pengendalian gizi berbasis android ini dengan menggunakan waterfall model. Dalam pengujian perangkat lunak peneliti menggunakan penilaian dengan pendekatan karakteristik perangkat lunak software product quality model BS ISO 25010. Dalam membuat model rancangan sistem algoritma penyelesaian masalah peneliti menggunakan flowchart dan pseudocode. Perangkat lunak pembangun sistem menggunakan android studio versi 3.6.1 dengan database SQLite. Dalam teknik pengumpulan data peneliti menggunakan cara observasi, studi literatur, dan wawancara. Teknik analisis data dengan menggunakan analisis data kualitatif. Kata Kunci : Artificial intellegence, sistem pakar berbasis android, monitoring dan pengendalian gizi