bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subgenual cingulate resting regional cerebral blood flow in premenstrual dysphoric disorder: differential regulation by ovarian steroids and preliminary evidence for an association with expression of ESC/E(Z) complex genes
Authors: Wei Shau-Ming , Baller Erica B. , Martinez Pedro E. , Goff Allison C. , Li Howard J. , Kohn Philip D. , Kippenhan J. Shane , Soldin Steven J. , Rubinow David R. , Goldman David , Schmidt Peter J. , Berman Karen F. 
Published: April 2021

AbstractSubstantial evidence suggests that circulating ovarian steroids modulate behavior differently in women with PMDD than in those without this condition. However, hormonal state-related abnormalities of neural functioning in PMDD remain to be better characterized. In addition, while altered neural function in PMDD likely co-exists with alterations in intrinsic cellular function, such a relationship has not been explored. Here, we investigated the effects of ovarian steroids on basal, resting regional cerebral blood flow (rCBF) in PMDD, and, in an exploratory analysis, we tested whether the rCBF findings were linked to the expression of ESC/E(Z) genes, which form an essential ovarian steroid-regulated gene-silencing complex. Resting rCBF was measured with oxygen-15 water PET (189 PET sessions in 43 healthy women and 20 women with PMDD) during three self-as-own-control conditions: GnRH agonist (Lupron)-induced ovarian suppression, estradiol add-back, and progesterone add-back. ESC/E(Z) gene expression data were obtained from RNA-sequencing of lymphoblastoid cell lines performed in a previous study and were examined in relation to hormone-induced changes in rCBF. In the rCBF PET data, there was a significant diagnosis-by-hormone interaction in the subgenual cingulate (PFDR = 0.05), an important neuroanatomical hub for regulating affective state. Whereas control women showed no hormonally-related changes in resting rCBF, those with PMDD showed decreased resting rCBF during both estradiol (P = 0.02) and progesterone (P = 0.0002) add-back conditions. In addition, in PMDD, ESC/E(Z) gene expression correlated with the change in resting rCBF between Lupron-alone and progesterone conditions (Pearson r = −0.807, P = 0.016). This work offers a formulation of PMDD that integrates behavioral, neural circuit, and cellular mechanisms, and may provide new targets for future therapeutic interventions.
Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
Authors: Agashe Sumedha , Joseph Chinnu Rose , Reyes Teresa Anne Clarisse , Menolfi Demis , Giannattasio Michele , Waizenegger Anja , Szakal Barnabas , Branzei Dana 
Published: April 2021

AbstractSmc5/6 is essential for genome structural integrity by yet unknown mechanisms. Here we find that Smc5/6 co-localizes with the DNA crossed-strand processing complex Sgs1-Top3-Rmi1 (STR) at genomic regions known as natural pausing sites (NPSs) where it facilitates Top3 retention. Individual depletions of STR subunits and Smc5/6 cause similar accumulation of joint molecules (JMs) composed of reversed forks, double Holliday Junctions and hemicatenanes, indicative of Smc5/6 regulating Sgs1 and Top3 DNA processing activities. We isolate an intra-allelic suppressor of smc6-56 proficient in Top3 retention but affected in pathways that act complementarily with Sgs1 and Top3 to resolve JMs arising at replication termination. Upon replication stress, the smc6-56 suppressor requires STR and Mus81-Mms4 functions for recovery, but not Srs2 and Mph1 helicases that prevent maturation of recombination intermediates. Thus, Smc5/6 functions jointly with Top3 and STR to mediate replication completion and influences the function of other DNA crossed-strand processing enzymes at NPSs.
Online adaptive quantum characterization of a nuclear spin
Authors: Joas Timo , Schmitt Simon , Santagati Raffaele , Gentile Antonio Andrea , Bonato Cristian , Laing Anthony , McGuinness Liam P. , Jelezko Fedor 
Published: April 2021

AbstractThe characterization of quantum systems is both a theoretical and technical challenge. Theoretical because of the exponentially increasing complexity with system size and the fragility of quantum states under observation. Technical because of the requirement to manipulate and read out individual atomic or photonic elements. Adaptive methods can help to overcome these challenges by optimizing the amount of information each measurement provides and reducing the necessary resources. Their implementation, however, requires fast-feedback and complex processing algorithms. Here, we implement online adaptive sensing with single spins and demonstrate close to photon shot noise limited performance with high repetition rate, including experimental overheads. We further use fast feedback to determine the hyperfine coupling of a nuclear spin to the nitrogen-vacancy sensor with a sensitivity of$$445\,{\mathrm{nT}}{\sqrt{\mathrm{Hz}}}^{- 1}$$445nTHz−1. Our experiment is a proof of concept that online adaptive techniques can be a versatile tool to enable faster characterization of the spin environment.
Gigahertz measurement-device-independent quantum key distribution using directly modulated lasers
Authors: Woodward R. I. , Lo Y. S. , Pittaluga M. , Minder M. , Paraïso T. K. , Lucamarini M. , Yuan Z. L. , Shields A. J. 
Published: April 2021

AbstractMeasurement-device-independent quantum key distribution (MDI-QKD) is a technique for quantum-secured communication that eliminates all detector side-channels, although is currently limited by implementation complexity and low secure key rates. Here, we introduce a simple and compact MDI-QKD system design at gigahertz clock rates with enhanced resilience to laser fluctuations—thus enabling free-running semiconductor laser sources to be employed without spectral or phase feedback. This is achieved using direct laser modulation, carefully exploiting gain-switching and injection-locking laser dynamics to encode phase-modulated time-bin bits. Our design enables secure key rates that improve upon the state of the art by an order of magnitude, up to 8 bps at 54 dB channel loss and 2 kbps in the finite-size regime for 30 dB channel loss. This greatly simplified MDI-QKD system design and proof-of-principle demonstration shows that MDI-QKD is a practical, high-performance solution for future quantum communication networks.
A low-cost, high-efficiency, new generation material for fog harvesting fumed silica-doped polypropylene
Authors: Kari̇per İ. Afşin 
Published: April 2021

AbstractThis study describes the development of a fog collector material for fog harvesting. Polypropylene (PP) doped with fumed silica (0–2%) was punctured at equal intervals and exposed to fog produced by a humidifier. The amount of water harvested by each sample was measured using an ultrasonic fogger. Polypropylene doped with 1% fumed silica was most effective at harvesting water, and collected almost 19–20 times more water than pure polypropylene. This improvement is due to the surface tension, which decreased from 16.754 mN/m (pure PP) to 13.512 and 9.992 mN/m (0.5% and 1% fumed silica, respectively). On the other hand, when fumed silica doping exceeded 1%, this increased the polymer’s surface tension, measured as 20.6 and 38.1 mN/m for 1.5 and 2% fumed silica doping. We therefore propose fog harvesting using 1% fumed silica-doped polypropylene as a low-cost method for collecting clean water in arid regions.
Single-pixel imaging of dynamic objects using multi-frame motion estimation
Authors: Monin Sagi , Hahamovich Evgeny , Rosenthal Amir 
Published: April 2021

AbstractSingle-pixel imaging (SPI) enables the visualization of objects with a single detector by using a sequence of spatially modulated illumination patterns. For natural images, the number of illumination patterns may be smaller than the number of pixels when compressed-sensing algorithms are used. Nonetheless, the sequential nature of the SPI measurement requires that the object remains static until the signals from all the required patterns have been collected. In this paper, we present a new approach to SPI that enables imaging scenarios in which the imaged object, or parts thereof, moves within the imaging plane during data acquisition. Our algorithms estimate the motion direction from inter-frame cross-correlations and incorporate it in the reconstruction model. Moreover, when the illumination pattern is cyclic, the motion may be estimated directly from the raw data, further increasing the numerical efficiency of the algorithm. A demonstration of our approach is presented for both numerically simulated and measured data.
Adverse body measurements are superior to sarcopenia-associated measurements in predicting chronic diseases
Authors: Liao Pei-Ju , Lin Yu-Ching , Ting Ming-Kuo , Wu I.-W.en , Chen Shuo-Wei , Yang Ning-I. , Hsu Kuang-Hung 
Published: April 2021

AbstractFew studies have demonstrated an association of sarcopenia-associated body measurements with chronic diseases through a comprehensive methodology. This study aims to examine the relationship between sarcopenia-associated body measurements and chronic diseases. This is a cohort study. We recruited 316 community dwellers, including 76 patients with sarcopenia and 240 controls, and obtained their body measurements associated with sarcopenia. We collected three-dimensional anthropometric body-surface measurements from 11,158 participants during 2000–2008 and followed up this cohort for 15 years to examine the association of these measurements with the risk of chronic diseases such as hypertension, type 2 diabetes mellitus (T2DM), heart disease, and nephrotic syndrome. Univariate analysis, canonical correlation, and Cox regression analysis were performed to explore the associations. Decreased waist width, upper left arm circumference, and left thigh circumference were significantly associated with sarcopenia. The adverse body measure score (ABMS) was derived by combining significant measurements, namely left upper arm circumference, waist width, and left thigh circumference, and used to predict the risk of hypertension, T2DM, heart diseases, and nephrotic syndrome. A positive association was observed between the ABMS and chronic diseases. Considering the first quartile of the ABMS as a reference, we determined hazard ratios of 2.259, 2.495, 1.332, and 1.595 for hypertension, T2DM, heart disease, and nephrotic syndrome, respectively, in the fourth quartile. Chronic diseases were more strongly associated with the ABMS than with sarcopenia-related body measurements alone. A high ABMS, which includes higher upper arm circumference, higher waist width, and lower thigh circumference, can significantly predict chronic diseases.
Scattering-lens based quantum imaging beyond shot noise
Authors: Li Dong , Yao Yao 
Published: April 2021

AbstractThe scheme of optical imaging using scattering lens can provide a resolution beyond the classical optical diffraction limit with a coherent-state input. Nevertheless, due to the shot noise of the coherent state, the corresponding signal-to-noise ratio and resolution are both still shot-noise-limited. In order to circumvent this problem, we theoretically propose an alternative scheme where the squeezed state (with a sub-shot noise) is considered as input and the quantum noise is then suppressed below the shot-noise level. Consequently, when comparing with the previous imaging scheme (using combination of coherent state and scattering lens), our proposal is able to achieve an enhanced signal-to-noise ratio for a given scattering lens. Meanwhile, it is demonstrated that the resolution is also improved. We believe that this method may afford a new way of using squeezed states and enable a higher performance than that of using coherent state and scattering lens.
Self-sampling of capillary blood for SARS-CoV-2 serology
Authors: Brown Lottie , Byrne Rachel L. , Fraser Alice , Owen Sophie I. , Cubas-Atienzar Ana I. , Williams Christopher T. , Kay Grant A. , Cuevas Luis E. , Fitchett Joseph R. A. , Fletcher Tom , Garrod Gala , Kontogianni Konstantina , Krishna Sanjeev , Menzies Stefanie , Planche Tim , Sainter Chris , Staines Henry M. , Turtle Lance , Adams Emily R. 
Published: April 2021

AbstractSerological testing is emerging as a powerful tool to progress our understanding of COVID-19 exposure, transmission and immune response. Large-scale testing is limited by the need for in-person blood collection by staff trained in venepuncture, and the limited sensitivity of lateral flow tests. Capillary blood self-sampling and postage to laboratories for analysis could provide a reliable alternative. Two-hundred and nine matched venous and capillary blood samples were obtained from thirty nine participants and analysed using a COVID-19 IgG ELISA to detect antibodies against SARS-CoV-2. Thirty eight out of thirty nine participants were able to self-collect an adequate sample of capillary blood (≥ 50 µl). Using plasma from venous blood collected in lithium heparin as the reference standard, matched capillary blood samples, collected in lithium heparin-treated tubes and on filter paper as dried blood spots, achieved a Cohen’s kappa coefficient of > 0.88 (near-perfect agreement, 95% CI 0.738–1.000). Storage of capillary blood at room temperature for up to 7 days post sampling did not affect concordance. Our results indicate that capillary blood self-sampling is a reliable and feasible alternative to venepuncture for serological assessment in COVID-19.
New vectors that are early feeders for Plasmodium knowlesi and other simian malaria parasites in Sarawak, Malaysian Borneo
Authors: De Ang Joshua Xin , Yaman Khatijah , Kadir Khamisah Abdul , Matusop Asmad , Singh Balbir 
Published: April 2021

AbstractPlasmodium knowlesi is the main cause of malaria in Sarawak, where studies on vectors of P. knowlesi have been conducted in only two districts. Anopheles balabacensis and An. donaldi were incriminated as vectors in Lawas and An. latens in Kapit. We studied a third location in Sarawak, Betong, where of 2169 mosquitoes collected over 36 days using human-landing catches, 169 (7.8%) were Anopheles spp. PCR and phylogenetic analyses identified P. knowlesi and/or P. cynomolgi, P. fieldi, P. inui, P. coatneyi and possibly novel Plasmodium spp. in salivary glands of An. latens and An. introlatus from the Leucosphyrus Group and in An. collessi and An. roperi from the Umbrosus Group. Phylogenetic analyses of cytochrome oxidase subunit I sequences indicated three P. knowlesi-positive An. introlatus had been misidentified morphologically as An. latens, while An. collessi and An. roperi could not be delineated using the region sequenced. Almost all vectors from the Leucosphyrus Group were biting after 1800 h but those belonging to the Umbrosus Group were also biting between 0700 and 1100 h. Our study incriminated new vectors of knowlesi malaria in Sarawak and underscores the importance of including entomological studies during the daytime to obtain a comprehensive understanding of the transmission dynamics of malaria.
Effects of sediment replenishment on riverbed environments and macroinvertebrate assemblages downstream of a dam
Authors: Katano Izumi , Negishi Junjiro N. , Minagawa Tomoko , Doi Hideyuki , Kawaguchi Yôichi , Kayaba Yuichi 
Published: April 2021

AbstractRiverbeds downstream of dams are starved of sediment, impacting habitat structure and ecological function. Despite the implementation of sediment management techniques, there has been no evaluation of their conservational effectiveness; the impacts on high trophic level organisms remain unknown. This study examined the effects of sediment replenishment on riverbeds and macroinvertebrates in a dammed river before and after sediment replenishment. We evaluated the particle sizes of replenished sediments and the case material of a case-bearing caddisfly. We observed significant changes in macroinvertebrate assemblages before and after sediment replenishment, and between the upstream and tributary references and downstream of the dam. The percentages of Ephemeroptera, Plecoptera, and Trichoptera, and the number of inorganic case-bearing caddisflies downstream of the dam following sediment replenishment, were significantly higher than the upstream and tributary reference sites. The particle size of case materials used by case-bearing caddisfly corresponded to the size of the replenished sediment. Dissimilarity results after replenishment showed that assemblages downstream of the dam differed from upstream sites, although they were similar to the tributary sites. The dissimilarity between the tributary and downstream of the dam was the same as that between the upstream and tributary. Sediment replenishment was observed to reduce the harmful effects of the dam, and partly restore benefits such as increasing species diversity and altering community assemblages, similar to the effects of tributary inflows.
ZnO nucleation into trititanate nanotubes by ALD equipment techniques, a new way to functionalize layered metal oxides
Authors: Moreno Mabel , Arredondo Miryam , Ramasse Quentin M. , McLaren Matthew , Stötzner Philine , Förster Stefan , Benavente Eglantina , Salgado Caterina , Devis Sindy , Solar Paula , Velasquez Luis , González Guillermo 
Published: April 2021

AbstractIn this contribution, we explore the potential of atomic layer deposition (ALD) techniques for developing new semiconductor metal oxide composites. Specifically, we investigate the functionalization of multi-wall trititanate nanotubes, H2Ti3O7 NTs (sample T1) with zinc oxide employing two different ALD approaches: vapor phase metalation (VPM) using diethylzinc (Zn(C2H5)2, DEZ) as a unique ALD precursor, and multiple pulsed vapor phase infiltration (MPI) using DEZ and water as precursors. We obtained two different types of tubular H2Ti3O7 species containing ZnO in their structures. Multi-wall trititanate nanotubes with ZnO intercalated inside the tube wall sheets were the main products from the VPM infiltration (sample T2). On the other hand, MPI (sample T3) principally leads to single-wall nanotubes with a ZnO hierarchical bi-modal functionalization, thin film coating, and surface decorated with ZnO particles. The products were mainly characterized by electron microscopy, energy dispersive X-ray, powder X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. An initial evaluation of the optical characteristics of the products demonstrated that they behaved as semiconductors. The IR study revealed the role of water, endogenous and/or exogenous, in determining the structure and properties of the products. The results confirm that ALD is a versatile tool, promising for developing tailor-made semiconductor materials.
Phenotypic plasticity explains apparent reverse evolution of fat synthesis in parasitic wasps
Authors: Visser Bertanne , Alborn Hans T. , Rondeaux Suzon , Haillot Manon , Hance Thierry , Rebar Darren , Riederer Jana M. , Tiso Stefano , van Eldijk Timo J. B. , Weissing Franz J. , Nieberding Caroline M. 
Published: April 2021

AbstractNumerous cases of evolutionary trait loss and regain have been reported over the years. Here, we argue that such reverse evolution can also become apparent when trait expression is plastic in response to the environment. We tested this idea for the loss and regain of fat synthesis in parasitic wasps. We first show experimentally that the waspLeptopilina heterotomaswitches lipogenesis on in a fat-poor environment, and completely off in a fat-rich environment. Plasticity suggests that this species did not regain fat synthesis, but that it can be switched off in some environmental settings. We then compared DNA sequence variation and protein domains of several more distantly related parasitoid species thought to have lost lipogenesis, and found no evidence for non-functionality of key lipogenesis genes. This suggests that other parasitoids may also show plasticity of fat synthesis. Last, we used individual-based simulations to show that a switch for plastic expression can remain functional in the genome for thousands of generations, even if it is only used sporadically. The evolution of plasticity could thus also explain other examples of apparent reverse evolution.
Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
Authors: Chung Mu-Chi , Lin Cheng-Li , Wu Ming-Ju , Chen Cheng-Hsu , Shieh Jeng-Jer , Chung Chi-Jung , Li Chi-Yuan , Yu Tung-Min 
Published: April 2021

AbstractWe analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted by propensity score matching. Cox proportional hazard models and competing death risk model were used to estimate the hazard ratios (HRs), sub-hazard ratios (SHRs) and corresponding 95% confidence intervals (CIs). There were 3442 patients with PA and 3442 patients without PA. The incidence rate of bladder stones was 5.36 and 3.76 per 1000 person-years for both groups, respectively. In adjusted Cox hazard proportional regression models, the HR of bladder stones was 1.68 (95% CI 1.20–2.34) for patients with PA compared to individuals without PA. Considering the competing risk of death, the SHR of bladder stones still indicates a higher risk for PA than a comparison cohort (SHR, 1.79; 95% CI 1.30–2.44). PA, age, sex, and fracture number were the variables significantly contributing to the formation of bladder stones. In conclusion, PA is significantly associated with risk of bladder stones.
Grain-boundary segregation of magnesium in doped cuprous oxide and impact on electrical transport properties
Authors: Resende João , Nguyen Van-Son , Fleischmann Claudia , Bottiglieri Lorenzo , Brochen Stéphane , Vandervorst Wilfried , Favre Wilfried , Jiménez Carmen , Deschanvres Jean-Luc , Nguyen Ngoc Duy 
Published: April 2021

AbstractIn this study, we report the segregation of magnesium in the grain boundaries of magnesium-doped cuprous oxide (Cu2O:Mg) thin films as revealed by atom probe tomography and the consequences of the dopant presence on the temperature-dependent Hall effect properties. The incorporation of magnesium as a divalent cation was achieved by aerosol-assisted metal organic chemical vapour deposition, followed by thermal treatments under oxidizing conditions. We observe that, in comparison with intrinsic cuprous oxide, the electronic transport is improved in Cu2O:Mg with a reduction of resistivity to 13.3 ± 0.1 Ω cm, despite the reduction of hole mobility in the doped films, due to higher grain-boundary scattering. The Hall carrier concentration dependence with temperature showed the presence of an acceptor level associated with an ionization energy of 125 ± 9 meV, similar to the energy value of a large size impurity−vacancy complex. Atom probe tomography shows a magnesium incorporation of 5%, which is substantially present at the grain boundaries of the Cu2O.