bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain Functional and Structural Alterations in Women With Bipolar Disorder and Suicidality
Authors: Guo Huiling , Zhang Ran , Wang Pengshuo , Zhang Luheng , Yin Zhiyang , Zhang Yifan , Wei Shengnan , Chang Miao , Jiang Xiaowei , Tang Yanqing , Wang Fei 
Published: April 2021

Objective: Suicide is the leading cause of death from bipolar disorder (BD). At least 25–50% of the patients with BD will attempt suicide, with suicide rates much higher in women patients than in men. It is crucial to explore the potential neural mechanism underlying suicidality in women with BD, which will lead to understanding and detection of suicidality and prevent death and injury from suicide.Methods: Brain function and structure were measured by amplitude of low-frequency fluctuation (ALFF) and gray matter volume (GMV) in 155 women [30 women with BD and a history of suicidality, 50 women with BD without suicidality, and 75 healthy controls (HC)]. The differences in ALFF and GMV across the BD with suicidality, BD without suicidality, and HC groups were investigated.Results: BD with suicidality showed significantly increased ALFF in the left and right cuneus compared with BD without suicidality and HC groups. Moreover, the GMV in the left lateral prefrontal cortex and left cuneus in BD with suicidality were significantly lower than those in BD without suicidality and HC groups, while the GMV of the right ventral prefrontal cortex was significantly decreased in both BD with and without suicidality groups.Conclusions: This study, combining functional and structural neuroimaging techniques, may help to identify specific pathophysiological changes in women with BD and suicidality. Increased ALFF and less GMV in cuneus might represent the neuroimaging features of suicidality in women with BD. Investigating this potential neuromarker for suicidality in women with BD may lead to the ability to prevent suicidality.
The Psychological Status of General Population in Hubei Province During the COVID-19 Outbreak: A Cross-Sectional Survey Study
Authors: Chen Guanmao , Gong Jiaying , Qi Zhangzhang , Zhong Shuming , Su Ting , Wang Jurong , Fu Siying , Huang Li , Wang Ying 
Published: April 2021

Introduction: The current outbreak of the novel coronavirus disease 2019 (COVID-19), originating from Wuhan (Hubei, China), has rapidly spread across China and several other countries. During the outbreak of COVID-19, mental health of the general population in Hubei province may be affected. This study aimed to assess the psychological status and associated risk factors of the general population in Hubei province during the COVID-19 outbreak.Methods: A cross-sectional online survey was used to evaluate the symptoms of posttraumatic stress disorder (PTSD), depression, and anxiety, which were assessed by the Chinese version of the Impact of Event Scale—Revised, the Patient Health Questionnaire 9, and the seven-item Generalized Anxiety Disorder Scale, respectively. Coping style was assessed by the Simplified Coping Style Questionnaire. Multivariate logistic regression analysis was carried out to detect factors associated with mental health outcomes.Results: Among 9,225 participants, 44.5% rated symptoms of PTSD, and 17.9 and 12.7% suffered from moderate and severe symptoms of depression and anxiety, respectively. Individuals who were geographically located in Wuhan and familiar with someone who has COVID-19 had more severe symptoms of PTSD, depression, and anxiety, as well as a higher score in passive coping style (P &lt; 0.05). Multivariate logistic regression analysis showed that people who were geographically located in Wuhan [odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.14–1.36, P &lt; 0.001] were associated with severe symptoms of PTSD. Besides, individuals who were familiar with someone who had COVID-19 (OR = 2.33, 95% CI = 2.07–2.63, P &lt; 0.001; OR = 1.90, 95% CI = 1.66–2.17, P &lt; 0.001; OR = 2.06, 95% CI = 1.78–2.39, P &lt; 0.001) and had a higher score in passive coping style (OR = 1.16, 95% CI = 1.14–1.17, P &lt; 0.001; OR = 1.17, 95% CI = 1.15–1.19, P &lt; 0.001; OR = 1.17, 95% CI = 1.15–1.19, P &lt; 0.001) were associated with severe symptoms of PTSD, depression, and anxiety. Moreover, a higher score in active coping style (OR = 0.96, 95% CI = 0.95–0.97, P &lt; 0.001; OR = 0.94, 95% CI = 0.93–0.94, P &lt; 0.001; OR = 0.95, 95% CI = 0.94–0.96, P &lt; 0.001) was associated with a lower risk of symptoms of PTSD, depression, and anxiety.Conclusions: During the midphase of COVID-19 outbreak, quite a few people have mental health problems; nearly half of the respondents rated symptoms of PTSD, and approximately one-fifth reported moderate to severe symptoms of anxiety and depression. Our findings may lead to better comprehend the psychological status of the general public and alleviate the public mental health crisis during the COVID-19 outbreak.
Comparative Utility of Genetic Determinants of Drug Resistance and Phenotypic Drug Susceptibility Profiling in Predicting Clinical Outcomes in Patients With Multidrug-Resistant Mycobacterium tuberculosis
Authors: Che Yang , Yang Tianchi , Lin Lv , Xiao Yue , Jiang Feng , Chen Yanfei , Chen Tong , Zhou Jifang 
Published: April 2021

Setting: Programmatic management of drug-resistant tuberculosis in Ningbo, China.Objective: To assess whether data-driven genetic determinants of drug resistance patterns could outperform phenotypic drug susceptibility testing in predicting clinical meaningful outcomes among patients with multidrug-resistant tuberculosis (MDR-TB).Design: We conducted a prospective cohort study of 104 MDR-TB patients. All MDR-TB isolates underwent drug susceptibility testing and genotyping for mutations that could cause drug resistance. Study outcomes were time to sputum smear conversion and probability of treatment success, as well as time to culture conversion within 6 months. Data were analyzed using latent class analysis, Kaplan–Meier curves, and Cox regression models.Results: We report that latent class analysis of data identified two latent classes that predicted sputum smear conversion with P = 0.001 and area under receiver-operating characteristic curve of 0.73. The predicted latent class memberships were associated with superior capability in predicting sputum culture conversion at 6 months and overall treatment success compared to phenotypic drug susceptibility profiling using boosted logistic regression models.Conclusion: These results suggest that genetic determinants of drug resistance in combination with phenotypic drug-resistant tests could serve as useful biomarkers in predicting treatment prognosis in MDR-TB.
Validation of a Modified Submaximal Balke Protocol to Assess Cardiorespiratory Fitness in Individuals at High Risk of or With Chronic Health Conditions—A Pilot Study
Authors: Eike Gert Sander Hamre , Aadland Eivind , Blom Ellen Eimhjellen , Riiser Amund 
Published: April 2021

Objectives: This study aims to validate a submaximal treadmill walking test for estimation of maximal oxygen consumption (VO2max) in individuals at high risk of or with chronic health conditions.Method: Eighteen participants (age 62 ± 16 years; VO2max 31.2 ± 5.9 ml kg−1 min−1) at high risk of getting or with established chronic diseases performed two valid modified Balke treadmill walking protocols, one submaximal protocol, and one maximal protocol. Test duration, heart rate (HR), and rate of perceived exertion (RPE) were measured during both tests. VO2max was measured during the maximal test. VO2max was estimated from the submaximal test by multiple regression using time to RPE ≥ 17, gender, age, and body mass as independent variables. Model fit was reported as explained variance (R2) and standard error of the estimate (SEE).Results: The model fit for estimation of VO2max from time to RPE ≥ 17 at the submaximal test, body mass, age, and gender was R2 = 0.78 (SEE = 3.1 ml kg−1 min−1, p ≤ 0.001). Including heart rate measurement did not improve the model fit.Conclusions: The submaximal walking test is feasible and valid for assessing cardiorespiratory fitness in individuals with high risk of or chronic health conditions.
The Joint Ministerial Decree (SKB) of Islamic Defenders Front (FPI): Quo Vadis The Rule of Law and Human Rights?
Authors: Disantara Fradhana Putra 
Published: April 2021

The freedom of association is one of the fundamental rights of a country. However, in Indonesia, the problems regarding of the legitimacy and recognition of the right to freedom of association have become stronger after the issuance of a The Joint Ministerial Decree (SKB) regarding the dissolution of the Islamic Defenders Front (FPI). This research is a legal research. This research uses statutory and conceptual approaches by using primary and secondary legal materials. The two legal materials are inventoried in order to obtain a prescriptive legal analysis; as well as providing a holistic conceptual study of the legal issues discussed. The research result states that the dissolution of FPI by the government is an act that violates human rights, particularly the right to freedom of association. The government uses the doctrine of the militant democracy to dissolve FPI. Then, the dissolution of FPI by SKB contradicts by the principle of the rule of law. Therefore, the dissolution of FPI was not carried out through to the court. Therefore, it is necessary to follow up on the action against 'radical mass organizations' in the form of presidential regulations or government regulations as a derivative renewal of the regulations concerning mass organizations.
Development of multi-degree-of-freedom noncontact transportation using holding force in near-filed acoustic levitation and consideration of factors of unstable operation
Authors: Kikuchi Kouhei , Kong Deqing , Kajiwara Hidekazu , Aoyagi Manabu 
Published: April 2021

Abstract
A non-contact transport method using near-field acoustic levitation has been studied. In this research, the levitated object is transported by multiple stators in steps. This transport method requires a large number of stators, but it has the advantage of precisef positioning because the levitated object is stopped and held on each stator. In addition, by arranging stators in two dimensions, transportation in two-dimensional direction is realized, but stable operation is not obtained, such as unintended rotation in transportation. Through experiments and analysis, we clarified under what conditions the transported object rotates.
Detecting non-covalent interactions in high vacuum by single molecule force spectroscopy: a brief review
Authors: Yang Jinxia , Cui Shuxun 
Published: April 2021

Abstract
Non-covalent interactions are very important for nanostructures. The detection of non-covalent interactions at the molecular scale is very difficult since they are too weak to detect in most cases. The disturbance from the liquid environment can be eliminated in high vacuum, which makes the detection of non-covalent interactions possible. This review introduces a method of high vacuum single molecule force spectroscopy (SMFS) and summarizes a series of recent studies on non-covalent interactions by using SMFS. These studies include the van der Waals forces between a polymer chain and the substrate as well as the intrachain π–π interactions of a polymer chain, which cast new light on the non-covalent interactions.
Time-resolved spatial profiles of electron density and temperature in hydrogen plasmas induced by radiation from laser-produced tin plasmas for extreme ultraviolet lithography light sources
Authors: Kouge Kouichiro , Tomita Kentaro , Hotta Junya , Pan Yiming , Tomuro Hiroaki , Morita Masayuki , Yanagida Tatsuya , Uchino Kiichiro , Yamamoto Naoji 
Published: April 2021

Abstract
We observed the spatial and temporal changes of the electron density (n
e) and the electron temperature (T
e) of hydrogen plasmas around a laser-produced Sn plasma EUV source. The plasma parameters were measured by the laser Thomson scattering (LTS) method. In the experiment, the Sn plasmas are produced in H2 gas at a pressure of 50–200 Pa and the hydrogen plasmas were induced by radiation from the Sn plasmas. The LTS measurements were performed at distances 30–90 mm away from the Sn plasmas. In all cases, the strong bremsstrahlung radiation of the Sn plasmas easily overwhelmed the weak LTS signals. To suppress noise due to the radiation, the solid angle of radiation from the Sn plasmas was restricted. The experimental results show that the n
e was in the order of 1017 m−3 and T
e was around 0.7 eV.
Anesthetic management of a patient with hollow viscus perforation due to blunt abdominal trauma with grade IV hemorrhagic shock
Authors: Sudjud Reza Widianto , Pohan Djoni Kusumah , Kurniawan Muhammad Budi , Ramila Hana Nur 
Published: April 2021

Hemorrhagic shock is a form of hypovolemic shock in which severe blood loss leads to inadequate oxygen delivery at the cellular level. Death from hemorrhage represents a substantial global problem, with more than 60,000 deaths per year in the United States and an estimated 1.9 million deaths per year worldwide, 1.5 million of which result from physical trauma. This case report aims to stress the need of handling cases of hemorrhagic shock in accordance with damage control protocol.
Hemorrhagic shock management using permissive hypotension management, bleeding control, massive transfusion protocol (MTP), minimal crystalloid therapy, and adjuvant therapy is the best approach to get optimal outcome to prevent triad of death. In this case, the application of damage control resuscitation has not been fully implemented because of several constraints.
Key words: Hemorrhage; Hemorrhagic shock; Permissive hypotension; Massive Transfusion Protocol; MTP; Resuscitation; Damage control
Citation: Pohan DK, Sudjud RW, Kurniawan MB, Ramila HN. Anesthetic management on patient with hollow viscus perforation due to blunt abdominal trauma with grade IV hemorrhagic shock. Anaesth. pain intensive care 2021;25(2):217-221. DOI: 10.35975/apic.v25i2.1474
Received: 11 January 2021, Reviewed: 15 January 2021, Accepted: 16 February 2021
Evolution of ASA Physical status scoring system
Authors: Malik Mehreen , Urooj Sana , Imtiaz Aftab , Arif Arif Muhammad 
Published: April 2021

Anesthesia Preoperative evaluation holds a prime importance in improving overall patient outcomes and decreases hospital expenditure. The American Society of Anesthesiologists Physical Status scoring system ASA-PS was introduced 70 years back in clinical practice and it still holds the lime light for stratifying patient population and considering the risk index and mortality outcomes to warn the surgeon. How has it evolved since the passing years? We will see how over centuries it has evolved. ASA PS has been a significant predictor in depicting morbidity and mortality and evaluating peri-operative risks in patients going for surgery for clinicians, researchers, hospital administrators and government. Further addition of examples of modifying ASA PS status is necessary to make it more comprehensive and easier to use even for non-anesthetists to improve overall peri-operative morbidity and mortality.
Key words: ASA PS (American Society of Anesthesiology Physical Status); Peri-operative outcomes
Citation: Malik M, Urooj S, Imtiaz A, Arif AM. Evolution of ASA Physical status scoring system. Anaesth. pain intensive care 2021;25(2):225-232. DOI: 10.35975/apic.v25i2.1476
Received: , Reviewed: , Accepted:
COVID-19 and the fundamental role of bioethics
Authors: Esteban Luz Adriana Templos , Jurez Montserrat Guadalupe 
Published: April 2021

Key words: COVID-19, bioethics, palliative care
Citation: Esteban LAT, Jurez MG. COVID-19 and the fundamental role of bioethics. Anaesth pain intensive care 2021;25(2):244-245. DOI: 10.35975/apic.v25i2.1479
Received: 26 January 2021, Reviewed: 30 January 2021, Accepted: 13 February 2021
PAIN CARE ESSENTIALS
Authors: Ali Professor Liaquat 
Published: April 2021

The best kept secret in pain management is in your own hands. Pain Care Essentials offers the readers a fingertip access to numerous topics in still emerging field of pain medicine, including physical rehabilitation in pain management, peripheral nerve blocks, neuropathic pain, pediatric and elderly pain. This book provides an overview of pain mechanisms as currently understood, and details a variety of approaches to pain management used across a wide range of complementary disciplines.
Divided into four convenient sections; the book addresses Fundamentals and Evaluation, Treatment Modalities (including opioids, interventions and alternative medicine), common Chronic Pain and Urgent Pain Problems. Integrative care concepts are presented, emphasizing multi-disciplinary approaches to address the pain. Expert contributors describe therapeutic approaches of various pain conditions and implementing self-care management options.
Pembuatan Pupuk Kompos Di Dayah Sirajul Huda Al-Aziziyah Kabupaten Pidie Jaya, Aceh
Authors: Satriawan Halus , Muttaqiem Hakim , Najmuddin Najmuddin 
Published: April 2021

Kegiatan pengabdian kepada masyarakat dalam bentuk penyuluhan dan pelatihan ini bertujuan untuk membantu santri dan guru di Dayah Sirajul Huda Al-Aziziyah Desa Blang Awe Kecamatan Meuredu Kabupaten Pidie Jaya Provinsi Aceh. Kegiatan ini selama 14 hari dimulai sejak Sabtu, 20 Juli 2019 - 3 Agustus 2019. Alat yang dibutuhkan dalam proses pembuatan pupuk kompos ini adalah parang, timbangan, ember, pengukur suhu dan pH Tanah, terpal, talenan, kantong plastik (kresek), karung, tali. Sedangkan bahan yang digunakan jerami padi, kulit buah-buahan, kotoran ternak Sapi, EM-4, kapur dolomite, gula pasir dan air. Metode pengomposan dilakukan dengan menggunakan fermentasi (an-aerob). Adapun parameter pengamatan dari kegiatan ini adalah kecepatan fermentasi dari penggunaan EM-4 sebagai dekomposer terhadap bahan-bahan yang digunakan. Hasil pengomposan pupuk kompos dibuat dengan proses pengomposan menggunakan EM-4. Penggunaan EM-4 dapat menghasilkan pupuk organik dalam waktu yang lebih cepat dibandingkan dengan cara konvensional, yaitu selama 2 minggu. Dampak pada mitra yakni 1) adanya pemahaman secara teori dan praktik tentang proses pengolahan limbah organik menjadi pupuk kompos, dan 2) adanya keterampilan dalam pengolahan limbah organik (limbah pertanian dan ternak) menjadi kompos organik yang dapat dimanfaatkan dalam budidaya tanaman.Making Compost at Dayah Sirajul Huda Al-Aziziyah, Pidie Jaya Regency, AcehAbstractThis community service activity in the form of counseling and training aims to help students and teachers at Dayah Sirajul Huda Al-Aziziyah, Blang Awe Village, Meuredu District, Pidie Jaya Regency, Aceh Province. This activity lasted for 14 days starting from Saturday, July 20 2019 - August 3, 2019. The tools needed in the compost-making process are machetes, scales, buckets, temperature and pH gauges, tarpaulins, cutting boards, plastic bags (kresek), sacks. , rope. While the materials used are rice straw, fruit skins, cow manure, EM-4, dolomite lime, sugar and water. The composting method is carried out using fermentation (an-aerobic). The observation parameter of this activity is the fermentation speed of using EM-4 as a decomposer for the materials used. The results of composting compost made by composting using EM-4. The use of EM-4 can produce organic fertilizers in a faster time than conventional methods, namely for 2 weeks. The impact on partners is 1) theoretical and practical understanding of the process of processing organic waste into compost, and 2) skills in processing organic waste (agricultural and livestock waste) into organic compost that can be used in plant cultivation.
NILAI TAMBAH PENGOLAHAN UBI KAYU MENJADI KULIT UBI KAYU PAKAN TERNAK, TEPUNG TAPIOKA, DAN AMPAS PAKAN TERNAK
Authors: Sitorus Nurmely V , Siamatupang Donny Ivan , Hasibuan Dedy Yusuf 
Published: April 2021

Penelitian ini antara lain untuk menguraikan tahapan pengolahan ubi kayu menjadi kulit ubi kayu pakan ternak, tepung tapioka dan ampas pakan ternak; menganalisis nilai tambah usaha pengolahan ubi kayu menjadi kulit ubi kayu pakan ternak, tepung tapioka dan ampas pakan ternak di daerah penelitian; menganalisis pendapatan produsen kulit ubi kayu pakan ternak, tepung tapioka dan ampas pakan ternak di daerah penelitian; menganalisis kelayakan usaha pengolahan ubi kayu menjadi kulit ubi kayu pakan ternak, tepung tapioka dan ampas pakan ternak di daerah penelitian.
Kegiatan tahap pengolahan yaitu: penyediaan bahan baku, pengupasan, pencucian, penggilingan, pengendapan, pengeringan air endapan, penjemuran, pengemasan, dan penyimpanan, tahapan pengolahan ubi kayu menjadi ampas pakan ternak di daerah penelitian dengan proses produksi meliputi kegiatan tahap pengolahan yaitu: penyediaan bahan baku, pengupasan, pencucian, penggilingan, penampungan ampas ubi kayu, pengemasan, dan penyimpanan. Usaha pengolahan ubi kayu menjadi kulit ubi kayu pakan ternak di daerah penelitian tidak layak untuk diusahakan karena nilai R/C rasio sebesar -0,14 < 1, BEP produksi sebesar 131,30 karung (produksi < BEP Produksi yaitu 18,40 karung < 131,36 karung), dan BEP harga yaitu Rp 71.392,54 ( harga jual < BEP Harga sebesar Rp 10.000 > Rp 71.392,54). Pengolahan ubi kayu menjadi tepung tapioka di daerah penelitian layak untuk diusahakan karena nilai R/C rasio sebesar 3,31 > 1, BEP produksi sebesar 416,77 Kg (produksi > BEP Produksi, yaitu 1.380,00 Kg > 416,77 Kg), dan BEP harga yaitu Rp 1.443,59 (harga jual < BEP Harga sebesar Rp 4.780 > Rp 1.443,59). pengolahan ubi kayu menjadi ampas pakan ternak di daerah penelitian tidak layak untuk diusahakan karena nilai R/C rasio sebesar 0,21 < 1, BEP produksi sebesar 216,00 karung (produksi < BEP Produksi, yaitu 46,00 karung < 216,00 karung), dan BEP harga yaitu Rp 70.434,23 (harga jual < BEP Harga sebesar Rp 15.000 < Rp 70.434,23).

Kata Kunci: Nilai Tambah, Pengelolahan Ubi Kayu, Nilai Tambah, Pakan Ternak, Kelayakan Usaha
PERBANDINGAN HASIL BELAJAR SISWA DENGAN MENGGUNAKAN PENDEKATAN SETS (SCIENCE, ENVIRONMENT, TECHNOLOGI AND SOCIETY) PADA MATERI EKOSISTEM
Authors: Siboro Thiur Dianti 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar siswa dengan menggunakan pendekatan SETS (science, environment, technologi and society) pada materi sistem pencernaan di kelas VIII SMP Negeri 3 Pematangsiantar. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 3 Pematangsiantar yang terdiri dari 8 kelas dengan jumlah 259 orang siswa. Sampel dalam penelitian ini berjumlah 64 siswa yang terdiri dari 2 kelas dengan pengambilan sampel dengan cara clusterrandom sampling. Analisis data dilakukan dengan cara mencari nilai rata-rata dan standart deviasi serta uji t. Dari hasil penelitian diperoleh nilai ratarata pre-test dan post-test kelas eksperimen sebesar 5,43 dan 8,86, sedangkan nilai rata-rata pretest dan post-test kelas kontrol sebesar 4,12 dan 7,17. Hal ini menunjukkan terdapat peningkatan setelah adanya penggunaan pendekatan SETS pada materi sistem pencernaan di kelas VIII SMP Negeri 3 Pematangsiantar. Dari hasil pengujian hipotesis diperoleh t-hitung (5,12) > t-tabel (2,00). maka H0 ditolak dan Ha diterima artinya ada perbedaan hasil belajar siswa yang signifikan dengan menggunakan pendekatan SETS (Science, Environment, Technologi and Society) pada materi sistem pencernaan kelas VIII SMP Negeri 3 Pematangsiantar. Disimpulkan terdapat perbedaan hasil belajar yang signifikan dengan menggunakan pendekatan Sets (Science, Environment, Technologi and Society) pada materi ekosistem di kelas VIII SMP Negeri 3 Pematangsiantar.