bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capacity development for small-scale women entrepreneurs and corporate social responsibility in Nigeria’s Niger Delta region
Authors: Uduji Joseph Ikechukwu , Okolo-Obasi Nduka Vitalis Elda , Uduji Joy Ukamaka , Emengini Emeka Steve , Odoh Longinus Chukwudi , Iyadi Rollins Chiyem 
Published: December 2024

Purpose
The purpose of this paper is to critically examine the multinational oil companies’ (MOCs) corporate social responsibility (CSR) initiatives in Nigeria. Its special focus is to investigate the impact of the global memorandum of understanding (GMoU) on capacity development for small-scale women entrepreneurs in the Niger Delta region of Nigeria.

Design/methodology/approach
This paper adopts a survey research technique, aimed at gathering information from a representative sample of the population, as it is essentially cross-sectional, describing and interpreting the current situation. A total of 768 women respondents were sampled across the rural areas of the Niger Delta region in Nigeria.

Findings
The results from the use of a combined propensity score matching and logit model indicate that though, a meagre part of the CSR intervention is targeted specifically for capacity empowerment of women, the CSR of the MOCs using the GMoU model has recorded little but significant success in building capacity of women in the areas of enhancing educational status, reduction in socio-economic barriers, access to credit, starting personal business enterprises, undertaking paid employment and generally enhancing means of livelihoods.

Practical implications
This suggests that if CSR interventions are not tailored to enhanced opportunities for women, they may contribute towards reducing the participation of women in economic, political and social development and, by extension, damping efforts of reducing poverty and achieving the sustainable development goals in the Niger Delta.

Social implications
This implies that the private sector, generally, can play an important role in addressing some of the logistical and cultural challenges that face rural women, and promote gender diversity and more equal access to economic opportunity through the CSR programmes in host communities.

Originality/value
This research contributes to the inequality debate in small-scale entrepreneurship and inclusive growth literature from the CSR perspective. It concludes that business has an obligation to help in solving problems of public concern.
Functional responses of Mediterranean flora to fire: A community‐scale perspective
Authors: Leys Bérangère A. , Leydet Michelle , Meineri Eric , Saatkamp Arne , Violle Cyrille 
Published: December 2024

Abstract

Fire regime is predicted to change, particularly in Mediterranean climate regions, towards more severe and frequent fire events. From a predictive perspective, trait‐based ecology offers a comprehensive framework to characterize vegetation responses to fire. Since fires induce erosion and decrease soil nutrients, species' functional traits and their distribution at community level should reflect these changes. Despite a vast literature focused on plant traits involved in resistance to fire, quantification of community trait responses to fire is lacking, particularly for traits that are linked to resource strategies.

Here, we emphasis on plant traits related to morphology (height, specific leaf area, stem and wood density) and resource acquisition strategies (leaf nitrogen, leaf dry mass, seed dry mass). We compiled three different databases compiling vegetation, fire and functional traits for the flora of Southern France. We analysed the relationships between these three components at both species and community levels.

Fire numbers and area burnt did not impact species trait distributions. At community level, a clear pattern emerged between the number of fires and the distribution of different traits considered, with two main axes: on the positive PC2 axis vegetative height and seed mass; and on negative PC1 axis leaf carbon and positive PC1 axis nitrogen content and leaf area. We also showed that vegetative height is positively correlated to the aridity index distribution in the region studied.

Synthesis: We analysed the relationships among fire, vegetation and functional traits, at both species and community levels. Altogether, there are highly significant direct relationships between the number of fires and leaf area (negatively) as well as seed mass (positively). For woody communities, wood density is also highly positively significant related to the number of fires. Overall, these findings suggest that fire may have an important impact on the functional response of plant communities, while not apparent when looking at individual species. Further, this research paves new ground to better understand the mechanisms behind trait convergence and the way plant communities respond to different environmental pressures.
Safety of Fertility Treatments in Women With Systemic Lupus Erythematosus: Data From a Prospective Population‐Based Study
Authors: Dernoncourt Amandine , Guettrot‐Imbert Gaëlle , Sentilhes Loïc , Besse Marie Charlotte , Molto Anna , Queyrel‐Moranne Viviane , Besnerais Maelle Le , Lazaro Estibaliz , Tieulié Nathalie , Richez Christophe , Hachulla Eric , Sarrot‐Reynauld Françoise , Leroux Gaëlle , Orquevaux Pauline , London Jonathan , Sailler Laurent , Souchaud‐Debouverie Odile , Smets Perrine , Godeau Bertrand , Pannier Emmanuelle , Murarasu Anne , Berezne Alice , Goulenok Tiphaine , Morel Nathalie , Mouthon Luc , Duhaut Pierre , Guern Véronique Le , Costedoat‐Chalumeau Nathalie ,   The Gr2 Study Group
Published: December 2024

ABSTRACTObjectiveTo assess safety of fertility treatments in women with systemic lupus erythematosus (SLE).DesignData from the multicentre French observational GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) study (2014‐ongoing).SettingSeventy‐six centres in France.PopulationAll pregnancies in women with SLE enrolled in the GR2 study, conceived before 1 August 2022, with available end‐of‐pregnancy data and known conception type, were included; that is, 577 spontaneous and 53 assisted pregnancies.MethodsA comparative analysis of spontaneous and assisted pregnancies was conducted. Logistic regression was used to determine if fertility treatments were independently associated with live birth prognosis, adjusting for confounders (e.g., maternal age). Kaplan–Meier analysis compared cumulative incidences of disease flares and adverse pregnancy outcomes (APOs), with confounding factors adjusted using a Cox regression model.Main Outcome MeasuresLive birth, disease flares, and APOs.ResultsThe mean age was older (35.8 vs. 32.3 years, p < 1 × 10−4), and twins were more frequent in assisted pregnancies (5/50, 10.0% vs. 20/554, 3.6%; p = 0.047). Lupus disease was clinically inactive at baseline in 51 (96.2%) assisted pregnancies (vs. n = 511, 89.6%; p = 0.15), with 35 of 45 (77.8%) having no chronic damage (vs. 448/513, 87.3%; p = 0.07). The live birth rate was similar between assisted and spontaneous pregnancies (n = 46, 86.8% vs. n = 505, 87.5%; p = 0.83), with no statistical difference in the incidence of lupus flares and APOs. These results remained consistent after adjusting for confounding factors.ConclusionsFertility treatments in women with mostly well‐controlled SLE did not appear to increase risks of maternal and neonatal complications, supporting current recommendations.Trial RegistrationClinicalTrials.gov identifier: NCT02450396
An accurate IDMS‐based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean
Authors: Li Lan , Chu Zhanying , Ning Kang , Zhu Manman , Lu Chenze , Zhai Rui , Xu Pei 
Published: December 2024

AbstractPhytohemagglutinin (PHA), a natural tetramer comprising PHA‐E and PHA‐L subunits that preferentially bind to red and white blood cells, respectively, constitutes a significant antinutritional and allergenic factor in common bean seeds. The accurate measurement of PHA content is a prerequisite for ensuring food safety inspections and facilitating genetic improvements in common bean cultivars with reduced PHA levels. Currently, mainstream methods for PHA quantification involve hemagglutination assays and immunodetection, but these methods often require fresh animal blood and lack specificity and accuracy. In this study, we present a novel liquid chromatography‐mass spectrometry/MS‐based method for PHA quantification, leveraging the advantages of isotope dilution mass spectrometry (IDMS). Two signature peptides each for PHA‐E and PHA‐L, along with a common signature peptide, were identified and employed for quantification, allowing differentiation between PHA‐E and PHA‐L subunits. The incorporation of amino acid analysis isotope IDMS enabled accurate determination of the synthetic signature peptides' purity during measurement, enhancing metrological accuracy. In addition, the trichloroacetic acid–acetone protocol was established as the optimized method for total protein extraction from dry bean seeds. Quantitative analysis of PHA‐E and PHA‐L subunits in six common bean varieties using the developed method demonstrated excellent linearity (R2 > 0.999), sensitivity (limit of detection and quantitation as low as 2.32 ng·mg−¹ and 7.73 ng·mg−¹, respectively), recovery (94.18%–104.47%), and precision (relative standard deviation < 3.45%). Collectively, we offer a precise and highly reproducible method that may be used as a standard for the determination of PHA content in common beans and other agricultural products containing PHA.
Efficacy and safety of a 72‐h infusion of prostacyclin (1 ng/kg/min) in mechanically ventilated patients with pulmonary infection and endotheliopathy—protocol for the multicenter randomized, placebo‐controlled, blinded, investigator‐initiated COMBAT‐ARF trial
Authors: Søe‐Jensen Peter , Clausen Niels E. , Bestle Morten H. , Andersen Lars P. K. , Lange Theis , Johansson Pär I. , Stensballe Jakob 
Published: December 2024

AbstractBackgroundAcute respiratory failure (ARF) is common in critically ill patients, and 50% of patients in intensive care units require mechanical ventilation [3, 4]. The COVID‐19 pandemic revealed that COVID‐19 infection induced ARF caused by damage to the microvascular pulmonary endothelium. In a randomized clinical trial, mechanically ventilated COVID‐19 patients with severe endotheliopathy, as defined by soluble thrombomodulin (sTM) ≥ 4 ng/mL, were randomized to evaluate the effect of a 72‐h infusion of low‐dose prostacyclin 1 ng/kg/min or placebo. Twenty‐eight‐day mortality was 21.9% versus 43.6% in the prostacyclin and the placebo groups, respectively (RR 0.50; CI 0.24 to 0.96 p = .06).The aim of the current trial is to investigate if this beneficial effect and safety of prostacyclin also are present in any patient with suspected pulmonary infection requiring mechanical ventilation and concomitant severe endotheliopathy.Materials and MethodsThis is a multi‐center, randomized, blinded, clinical investigator‐initiated phase 3 trial in mechanically ventilated patients with suspected pulmonary infection and severe endotheliopathy, as defined by sTM ≥4 ng/mL. Patients are randomized 1:1 to a 72‐h infusion of low‐dose prostacyclin (iloprost) 1 ng/kg/min or placebo (an equal volume of saline). Four‐hundred fifty patients will be included.The primary endpoint is 28‐day all‐cause mortality. Secondary endpoints include 90‐day mortality, days alive without vasopressor, mechanical ventilation, and renal replacement therapy in the ICU within 28 and 90 days, and the number of serious adverse reactions or serious adverse events within the first 7 days.DiscussionThis trial will investigate the efficacy and safety of prostacyclin vs. placebo for 72‐hours in mechanically ventilated patients with any suspected pulmonary infection and severe endotheliopathy, as defined by sTM ≥4 ng/mL. Trial endpoints focus on the potential effect of prostacyclin to reduce 28‐day all‐cause mortality.
Is it the right time to promote competency‐based European Training Requirements in Ophthalmology? A European Board of Ophthalmology survey
Authors: Dormegny Lea , Prior Filipe Helena , Dormegny‐Jeanjean Ludovic Christophe , Stopa Marcin , Aclimandos Wagih , Asoklis Rimvydas , Atilla Huban , Creuzot‐Garcher Catherine , Curtin Denise , Cvenkel Barbara , Flanagan Lisa , Ivekovic Renata , Kivelä Tero T. , Martinez Costa Rafael , Ní Dhubhghaill Sorcha , Priglinger Siegfried , Strong Brendan , Sturmer Joerg , Tassignon Marie José ,   Ophthalmology ETR working group, Maino Anna , Bourcier Tristan 
Published: December 2024

AbstractPurposeTo report national practices and recent progress in competency‐based medical education (CBME) implementation in ophthalmology across European countries.MethodsA 30‐question online survey was emailed to European Union of Medical Specialists (UEMS) ophthalmology section delegates, European Board of Ophthalmology Diploma (EBOD) examiners and presidents of ophthalmology societies affiliated with UEMS/EBO.ResultsA total of 230 ophthalmologists with an average age of 54.7 years [30–77] and from 28 countries completed the survey. Half of them had been involved as medical educators for more than 10 years. The majority (74%) exercised their educational role in a University Hospital. Ninety six percent of them dedicated less than 50% of their activity to teaching. A third dedicated more than a half of their activity to patient care. The teaching of skills reported (medical, surgical, research, attitudinal and theoretical knowledge) was significantly better applied than their assessment. While 91% of the respondents found it necessary to harmonize European Training Requirements (ETR) in ophthalmology, competency‐based education concepts were rarely implemented in their country (for instance, 8% for CBME; 6% for entrustable professional activities (EPAs) and 3% for ETR).ConclusionsDespite considerable diversity in European residency programmes, post‐graduate medical education leaders in ophthalmology agree on the need to find a platform for equivalence in the content of the basic training requirements that constitute the professional identity of a practicing ophthalmologist.
Isolating the role of researcher observation on reactivity to the measurement of physical activity
Authors: König Laura M. , Pasko Kristen , Baga Kiri , Harsora Raj , Arigo Danielle 
Published: December 2024

AbstractReactivity to physical activity (PA) measurement may result from the introduction of a measurement device, researcher observation, or both. Accessing data from prior to study enrollment afforded the rare opportunity to compare behavior during versus prior to participation. This study introduced researcher observation among adults who owned their own PA monitoring device, to test whether measurement reactivity can also be observed in experienced PA trackers, by comparing their data from before versus after the introduction of observation. In addition, the salience of researcher observation was manipulated to test for potential effects. Participants were 252 adults in the U.S. They completed two electronic surveys 14 days apart, in which they recorded steps per day as collected by their PA monitors over the previous 14 days. At the end of the first survey, they were randomized to view messages, which differed in emphasis on repeating entry of step data (i.e., “low” vs. “high” salience of researcher observation). Daily step counts did not change between 14‐day reporting periods, though patterns differed by gender and starting level of PA. Patterns did not differ between experimental conditions. Overall, introducing researcher observation without introducing an unfamiliar measurement device results in no meaningful reactivity with respect to PA.
Feasible Techniques Named “Pure” Robotic Simple Hysterectomy With 4 Robotic Arms “4+0” Mode for Hysterectomy in da Vinci Xi
Authors: Ota Kuniaki , Ota Yoshiaki , Kawamura Shogo , Fujiwara Hitomi , Tasaka Keitaro , Okamoto Hana , Morimoto Yumiko , Saito Wataru , Sugihara Mika , Koike Eiji , Shiota Mitsuru , Shimoya Koichiro 
Published: December 2024

ABSTRACTIntroductionThe three‐arm approach is mainly selected, despite the multiple robotic arms in da Vinci Xi. This type of surgical setup may provide less autonomy to the console surgeon and result in greater dependence on the bedside surgical assistant. Therefore, the 4th arm is used instead of the assist port, which is why we developed “pure” robot simple hysterectomy (PRSH) as a novel surgical technique, in which all ports are operated by robotic arms.Materials and Surgical TechniqueAfter pneumoperitoneum was established, trocars were inserted under visual control: three 8 mm robotic ports on the same horizontal line spaced 8 cm apart at the level of the endoscope port. The 2nd arm was used to insert the endoscope, and the fenestrated bipolar forceps in the 1st arm and Maryland bipolar forceps in the 3rd arm were operated using the double bipolar method. In this technique, the uterine manipulator is not used because the Cadiere forceps in the 4th arm manipulate the uterus. For suturing, the 3rd arm was equipped with a SutureCut needle driver from Maryland bipolar forceps, which enabled suturing and thread cutting. Suction and intra‐abdominal transport of the needle was introduced into the abdominal cavity by pulling out the instrument in the 3rd arm. Hence, since all robotic arms are used for all ports, we named this technique “pure” robot simple hysterectomy.DiscussionThe routine use of a fourth robotic arm “4+0” mode during PRSH provides the operating surgeon with greater independence during critical phases of the procedure without requiring a uterine manipulator and assistant.Trial Registration5043‐03
Olutasidenib demonstrates significant clinical activity in mutated IDH1 acute myeloid leukaemia arising from a prior myeloproliferative neoplasm
Authors: De Botton Stéphane , Récher Christian , Cortes Jorge , Curti Antonio , Fenaux Pierre , Peterlin Pierre , Pigneux Arnaud , Yee Karen , Wei Andrew , Mims Alice , Schiller Gary , Chao Mwe Mwe , Tian Hua , Watts Justin M. 
Published: December 2024

SummaryAcute myeloid leukaemia (AML) arising from a myeloproliferative neoplasm (MPN) is more aggressive and less responsive to therapies compared to de novo AML. Olutasidenib, an oral small‐molecule inhibitor of mutated IDH1 (mIDH1), showed encouraging and durable responses in a phase 1/2 study of adults with post‐MPN mIDH1 AML. Patients received olutasidenib 150 mg BID monotherapy or in combination with azacitidine. Primary end‐points: safety and best response defined as complete remission (CR), CR with partial haematological recovery or morphological leukaemia‐free state (MLFS). Analysis included 15 patients with post‐MPN mIDH1 AML; 10 had relapsed or refractory AML and five had newly diagnosed AML. Six were treated with olutasidenib monotherapy and nine in combination with azacitidine. Treatment emergent adverse events occurred in 15 patients, three of whom discontinued therapy. CR: 40% (n = 6/15); median duration of response: 15.6 months (range: 1.7–44.3); CR with incomplete haematological recovery: 13% (n = 2/15); MLFS: 7% (n = 1/15); composite complete remission (CRc): 53% (n = 8/15); and overall response rate (ORR): 60% (9/18). Median duration of CRc and ORR: 13.15 (range: 2.4–48.7) and 14.3 months (range: 2.4–48.7), respectively, and median overall survival: 13.8 months (95% confidence interval: 3.70–23.7). Olutasidenib demonstrated encouraging response rates with a manageable safety profile for patients with post‐MPN mIDH1 AML.
Strengthening Morale and Motivation in the Public Service in Turbulent Times
Authors: Levasseur Karine , Rounce Andrea , Wranik Wiesława Dominika 
Published: December 2024

AbstractThe public service in Canada has undergone major changes and experienced significant pressures in the last decade. These changes and pressures create conditions of uncertainty, and alongside workplace policies, arrangements, leadership, and culture, affect the morale of current public servants and future public service motivation. This issue requires immediate attention because the morale of the public service determines the performance and quality of service delivery to citizens, as well as making the public service a good place to work. This research note prescribes a pathway for reform: 1. Define problems of morale and motivation; 2. Create a time‐limited task force with the goal of creating a permanent entity to address motivation and morale; and 3. Collaborate with current and future public servants to provide professional development.
Development of a Self‐Care Autonomy in Health Scale for Late Adolescents
Authors: Mikhaylova Oxana , Denis Popov , Maria Chepeleva , Anastasia Bochkor , Ekaterina Serebrennaya , Polina Osipova 
Published: December 2024

ABSTRACTBackgroundThis paper describes the development of the Self‐Care Autonomy in Health Scale for Late Adolescents (SAHSLA) for use with general samples. It addresses concerns regarding the nonclinical efficacy of self‐care health scales for adolescents, particularly their ability to discriminate between lower levels of self‐care.MethodsA survey was constructed based on literature review and subsequently evaluated in two studies. Parents (N = 57, 53 parents of girls, 4 of boys, Mage = 15.96) participated in Study 1, which investigated the internal with Cronbach's alpha and coefficient omega (ω), and convergent validity with regard to adolescent age. In Study 2, the SAHSLA scores of adolescents (N = 339, 268 girls, 73 boys, Mage = 15.87) were examined using confirmatory factor and convergent validity analyses in relation to age, gender, smoking and alcohol consumption patterns, and self‐compassion assessments.ResultsIn Study 1, the scale total and a child's age did not substantially correlate. Both omega and alpha were moderate. Study 2 revealed a two‐factor model with physical and psychological components. There were minor yet statistically significant associations found between self‐judgement and psychological SAHSLA. Physical SAHSLA was not connected with age, overidentification, isolation or self‐judgement, but it was statistically strongly correlated with total self‐compassion.ConclusionsThe scale and study findings can be applied to health monitoring and interventions in schools and adolescent campaigns aimed at alcohol‐ and tobacco‐use cessation.