bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of fructose‐1,6‐bisphosphatase mRNA isoforms in normal and basal forebrain cholinergic lesioned rat brain
Authors: Löffler Thomas , Al‐Robaiy Samiya , Bigl Marina , Eschrich Klaus , Schliebs Reinhard 
Published: July 2002

AbstractFructose‐1,6‐bisphosphatase is one of the key enzymes in the gluconeogenic pathway predominantly occurring in liver, kidney and muscle. In the brain, fructose‐1,6‐bisphosphatase has been suggested to be an astrocyte‐specific enzyme but the functional importance of glyconeogenesis in the brain is still unclear. To further elucidate the cellular source of fructose‐1,6‐bisphosphatase in the brain, non‐radioactive in situ hybridizations were performed using digoxigenin‐labeled RNA probes based on the sequence of recently cloned rat liver and muscle fructose‐1,6‐bisphosphatase cDNAs. In situ hybridization using a riboprobe for the liver isoform revealed a location of the hybridization signal mainly in neurons, while rat muscle fructose‐1,6‐bisphosphatase mRNA was detected in both neurons and astrocytes in the hippocampal formation and in layer I of the cerebral cortex.RT‐PCR using RNA preparations of rat astrocytes, neurons, and adult whole brain demonstrated a localization of liver fructose‐1,6‐bisphosphatase mRNA isoform in neurons but not in astrocytes. The muscle fructose‐1,6‐bisphosphatase mRNA isoform could be detected by RT‐PCR in total rat brain, astrocytic, and neuronal mRNA preparations.The isoforms of fructose‐1,6‐bisphosphatase mRNA seemingly demonstrate a distinct cellular expression pattern in rat brain suggesting a role of glyconeogenesis in both neurons and glial cells.
Cellular interactions as a response to injury in the organ of corti in culture
Authors: Sobkowicz H.M. , August B.K. , Slapnick S.M. 
Published: July 2002

AbstractWe discovered and described ultrastructurally the intricate relationships between the sensory cells and their supporting cells in cultures of the organ of Corti following laser beam irradiation. Injury was performed using a 440 nm nitrogen‐dye pulse laser aimed at the cuticular plates of inner hair cells. Laser injury is compared with mechanical injury inflicted on the hair cell region by a pulled‐glass pipette. Regardless of the type of injury, but depending on its severity, the surviving hair cells may: (1) lose their stereocilia but subsist at the surface of the organ; (2) retain contact with the reticular lamina but be overgrown by the processes of the supporting cells; or (3) become sequestered from the reticular lamina and internalized among the supporting cells, where they either remain dedifferentiated or regrow an apical process which regains contact with the surface of the organ. All supporting cells, including pillar and Deiters' cells, take part in wrapping their respective inner or outer hair cells. The supporting cells not only cover the injured sensory cells, but also invert their villi toward the maimed cuticular plates and release an extracellular matrix around them. We suggest that the supporting cells play a protective and trophic role in the recovery of injured hair cells.
NGF content in the cerebral cortex of non‐dementedpatients with amyloid‐plaques and in symptomaticALZHEIMER'S disease
Authors: Hellweg Rainer , Gericke Christian A. , Jendroska Klaus , Hartung Heinz‐dieter , Cervós‐Navarro Jorge 
Published: July 2002

AbstractThere is increasing evidence that in Alzheimers disease nerve growth factor (NGF)protein and NGF mRNA content in post‐mortem cortex is not decreased, but may evenbe elevated although the NGF‐sensitive cholinergic basal forebrain neurons are preferentiallyaffected. However, only little is known about the early pathophysiological events leading toAlzheimers disease. We therefore measured the post‐mortem NGF concentrations intemporal and frontal cortex of Alzheimers disease patients, non‐demented controls withoutAlzheimers disease‐related pathology, as well as non‐demented patients with βA4plaques who might be classified as preclinical cases. In the Alzheimers disease group we found upto 43% increase in NGF concentrations in the frontal and temporal cortex as compared to the twoother groups. In a subgroup analysis of the non‐demented patients with plaques, NGFconcentrations were lower in the frontal cortex when βA4 plaques were present (46% ofthe control temporal area) than in patients without evidence of frontal plaques (81% of the controltemporal area). This NGF decrease was paralleled to a similar decrease of cholineacetyltransferase activity, which is regulated by NGF in the cholinergic basal forebrain. Thesefindings support the hypothesis of lower cortical NGF content at the onset of plaque formationand of elevated NGF levels in the clinically manifest and neuropathologically advanced stage ofthe disease.
Validation of an echocardiographic wall motion index in heart failure due to ischaemic heart disease
Authors: McGowan J.H. , Martin W. , Burgess M.I. , McCurrach G. , Ray S.G. , McDonagh T.A. , Cleland J.G.F. 
Published: July 2002

AbstractAims:the echocardiographic assessment of left ventricular ejection fraction (LVEF) by geometric methods is limited in many patients because of inadequate views and also in the presence of regional wall motion abnormalities due to ischaemic heart disease (IHD). This study aimed to examine the application of a wall motion index (WMI) method, using a nine‐segment LV model in patients with chronic heart failure (CHF) due to IHD.Methods and Results:echocardiography was performed in 71 consecutive subjects with CHF due to IHD. WMI could be derived in 70 subjects (99%). The inter‐observer variability (repeatability coefficient) of WMI was 0.66, i.e. LVEF±20%. In 66 subjects, LVEF was measured, within 4 weeks, using radionuclide ventriculography (RNV‐EF). The inter‐observer variability of RNV‐EF was ±3.1%. Using the mean of two observations for each method, the Bland–Altman range of agreement for LVEF was 26% (±13%).Conclusion:WMI is a widely applicable echocardiographic method for assessing LV systolic function and has moderate agreement with RNV‐EF. Unlike RNV‐EF, however, WMI is not likely to be a suitable method for the measurement of small, but prognostically important, changes in LV function that may occur in CHF.
KEEPING MAMMOGRAPHY REFERRAL APPOINTMENTS: MOTIVATION, HEALTH BELIEFS, AND ACCESS BARRIERS EXPERIENCED BY OLDER MINORITY WOMEN
Authors: Bernstein Judith , Mutschler Phyllis , Bernstein Edward 
Published: July 2002

ABSTRACTOlder women of color tend to have much lower rates of regular mammography screening for breast cancer than younger Caucasian women; yet, they have higher rates of mortality. This study was designed to increase mammography rates among inner‐city women aged 50 years or older. Another goal was to investigate differences in mammography utilization related to race/ethnicity and language after barriers associated with cost and the difficulty of making an appointment are removed. A peer delivered intervention, which consisted of interview, mammography referral, and the scheduling of a next‐day appointment, was conducted among a convenience sample of 151 culturally and racially diverse older women through a primary care referral project operating within an urban emergency department (ED). A brief motivational interview and mammography referral at the time of an ED visit, including scheduling of a next‐day no cost appointment, was followed by a cross‐sectional telephone survey of utilization and motivating and hindering factors. Follow‐up was achieved with 96 women (66%). Fifty‐eight women (60%) had a post‐intervention mammogram; of those, 69% were first time users. More than 90% planned a repeat mammogram the following year. Of the 27 who did not receive a mammogram, 21 (77%) requested a “second try” appointment. These findings demonstrate that an interactive intervention among older women of color has the potential to dramatically increase mammography rates.
Dynamic Control of Orthogonal Upconversion in Migratory Core–Shell Nanostructure toward Information Security
Authors: Huang Jinshu , Yan Long , Liu Songbin , Song Nan , Zhang Qinyuan , Zhou Bo 
Published: February 2021

AbstractLanthanide‐based materials exhibit abundant emission colors under suitable infrared excitations; however, the dynamic control of orthogonal photon upconversion of lanthanide ions has remained challenging. Here, a novel mechanistic strategy to enable orthogonal upconversion emissions through energy migration in a simple core–shell nanostructure is reported. By constructing the migratory ytterbium‐sublattice shell layer outside the luminescent erbium matrix, the population of erbium emitters at their intermediate energy levels can be finely manipulated, and the red‐to‐green color‐switchable output has been achieved under separate 980 and 808 (or 1530) nm excitations. More interestingly, a tuning of the excitation pulse width also results in a gradual red‐to‐green color change. The mechanistic role of energy migration over ytterbium sublattice is also examined. A conceptual core–shell model for the excitation‐emission orthogonal upconversion output is provided, which is not only important for the fundamental research of photon upconversion but also helps in exciting new chances for the frontier applications such as information security.
Lithiophilic and Antioxidative Copper Current Collectors for Highly Stable Lithium Metal Batteries
Authors: Fu Ang , Wang Chaozhi , Peng Jian , Su Min , Pei Fei , Cui Jingqin , Fang Xiaoliang , Li Jian‐Feng , Zheng Nanfeng 
Published: February 2021

AbstractDesigning copper (Cu) current collectors is a convenient way to stabilize lithium (Li) metal anodes. However, Cu current collectors and their derived Li/Cu anodes still face several obstacles, including lithiophobic and oxidizable Cu surface, cumbersome anode fabrication process, and low Li utilization. Here, a formate‐treatment strategy is presented to reconstruct Cu current collectors with a passivation layer covered Cu(110) surface. This method can easily be generalized to increase the lithiophilicity and oxidation resistibility of Cu current collectors. Using the formate‐treated Cu nanowire network as an anode current collector, the full cell consisting of a LiFePO4 cathode and Li/Cu anode with a low negative/positive capacity ratio delivers an excellent cycling performance with 74.8% capacity retention after 1000 cycles at 1 C. In addition, a concept of an upper current collector is introduced to simplify the manufacturing procedure of Li/Cu anodes. This work provides new insights into the design and construction of high‐performance Li/Cu anodes.
Characterization of Hierarchically Ordered Porous Materials by Physisorption and Mercury Porosimetry—A Tutorial Review
Authors: Schlumberger Carola , Thommes Matthias 
Published: February 2021

AbstractThis paper is devoted to the textural characterization of nanoporous materials with a focus on hierarchically ordered materials such as mesoporous zeolites, which exhibit an interconnected pore network consisting of micro‐, meso‐, and often macropores. Hierarchically ordered zeolites have the potential to improve various industrial applications for instance in the areas of heterogeneous catalysis, separation, gas, and energy storage. Detailed insights into the pore architecture are important, because they control transport phenomena, diffusional rates, and govern selectivity, e.g. in catalyzed reactions. However, a reliable characterization of such complex pore structures is still a major challenge. Within this context, the application of advanced physisorption methodologies for micro‐mesopore analysis is discussed but also the characterization of macroporosity by mercury porosimetry is addressed. Fundamental concepts and recent major advances in understanding the underlying mechanisms are highlighted. In conjunction with selected case studies, it is illustrated how the application of advanced physisorption methodologies allows i) for the determination of reliable surface areas, pore volumes, and pore size distributions and ii) for obtaining information about pore network characteristics. This tutorial offers guidance for an advanced characterization of nanoporous materials by physisorption and mercury intrusion/extrusion.
How corporate social responsibility influences consumer behavior: An empirical analysis in the Spanish agrifood sector
Authors: Mercadé‐Melé Pere , Fandos‐Herrera Carmina , Velasco‐Gómez Sofía 
Published: February 2021

AbstractThis study analyzes how corporate social responsibility (CSR) influences consumer behavior in the case of the Spanish agrifood sector. The originality of the study resides in the proposed model that explains that CSR influences perceptions of food safety and health, and quality, and that this perceived quality influences consumer behavior, that is, satisfaction and loyalty. Structural equation modeling was used to analyze the data from 295 personal interviews; satisfactory results were obtained for all the proposed relationships. Therefore, we suggest that, to achieve consumer loyalty, agrifood companies should orient their strategies toward creating sustainable relationships based on CSR actions. Other academic and management implications are proposed to complete the paper. [EconLit Citations: M14, M310, Q13].
Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood
Authors: Das Sweta , Godbole Koumudi , Abraham Suneetha Susan Cleave , Ganesan Paramasivam , Kamdar Payal , Danda Sumita 
Published: February 2021

AbstractAlazami syndrome (ALAZS) (MIM 615071) is a rare autosomal recessive disorder characterized by short stature, dysmorphic facial features, developmental delay, and impaired intellect. It was first reported in a Saudi Arabian family in 2012. Three Indian patients affected with ALAZS, one boy aged 13 years and other two sisters in their 40s are presented. These patients had few unreported dysmorphic facial features: high arched eyebrows and dental overcrowding. No microcephaly was noted in the sisters. One of the sisters did not have short stature. The boy also presented with unilateral buphthalmos of left eye. All three of them have been identified to harbor novel variants in LARP7.
Asymmetric Coordination Toward a Photoinduced Single‐Chain Magnet Showing High Coercivity Values
Authors: Liu Qiang , Hu Ji‐Xiang , Meng Yin‐Shan , Jiang Wen‐Jing , Wang Jun‐Li , Wen Wen , Wu Qiong , Zhu Hai‐Lang , Zhao Liang , Liu Tao 
Published: February 2021

AbstractThe production of photo‐switchable molecular nanomagnets with substantial coercivity, which is indispensable for information storage and process applications, is challenging. Introducing photo‐responsive spin‐crossover units provides a feasible means of controlling the magnetic anisotropy, interactions, and overall nanomagnet properties. Herein, we report a cyanide‐bridged chain 1⋅12H2O ({[(PzTp)FeIII(CN)3]2FeII(Pmat)2}n⋅12 H2O) generated by linking the FeII‐based spin‐crossover unit with the [(PzTp)Fe(CN)3]− (PzTp: tetrakis(pyrazolyl)borate) building block in the presence of asymmetric ditopic ligand Pmat ((4‐pyridine‐4‐yl)methyleneamino‐1,2,4‐triazole). Structural characterization revealed that the introduction of this asymmetric ligand led to a distorted coordination environment of FeII ions, which were equatorially coordinated by four cyanide N atoms, and apically coordinated by one pyridine N atom and one triazole N atom. Upon 808‐nm light irradiation, 1⋅12H2O underwent photoinduced spin‐crossover and exhibited single‐chain magnet behavior with a coercive field of up to 1.3 T. This represents a 3d‐based photoinduced single‐chain magnet exhibiting pronounced hysteresis.
Guidelines for Tuning the Excited State Hückel–Baird Hybrid Aromatic Character of Pro‐Aromatic Quinoidal Compounds**
Authors: Escayola Sílvia , Tonnelé Claire , Matito Eduard , Poater Albert , Ottosson Henrik , Solà Miquel , Casanova David 
Published: February 2021

AbstractPro‐aromatic molecules have higher‐energy diradicaloid states that are significantly influenced by resonance structures in which conjugated rings take on Hückel‐aromatic character. Recently, it has been argued that there are also pro‐aromatic molecules that adopt central units with 4nπ‐electron Baird‐aromatic character in the T1 state, although detailed analysis suggests that these compounds are better labelled as T1 Hückel–Baird hybrid molecules where Hückel‐aromaticity dominates. Herein, we consider a series of symmetrically substituted conjugated rings with potential Baird aromaticity in the lowest excited triplet and singlet states. Our computational results allow us to establish general guidelines for the rational design of molecules with excited state Hückel/Baird aromaticity in pro‐aromatic quinoidal compounds. We found two main strategies to promote high Baird aromatic character: 1) anionic and small conjugated rings with electron donating groups as substituents and small exocyclic groups with electron withdrawing substituents, or 2) electron deficient conjugated rings with exocyclic electron–donor substitution.
Development of optimized triaxially electrospun titania nanofiber‐in‐nanotube core‐shell structure
Authors: Khan Muhammad Amir , Ahmad Adnan , Arshad Salman Noshear , Nazir Ahsan , Ahmad Sheraz , Khan Muhammad Qamar , Shahzad Amir , Satti Aamir Naseem , Qadir Muhammad Bilal , Khaliq Zubair 
Published: February 2021

AbstractOne dimensional (1D) nanostructures and its derivatives can be manipulated to serve special functions like hollow structure, and higher surface area. 1D TiO2 nanotube‐in‐nanofibers (NF@NT) are developed through triaxial electrospinning followed by a calcination process. A blended solution of polyvinyl pyrrolidone and tetra‐butyl titanate is used in outer and inner layers of nanofibers, respectively, while paraffin oil is used in the middle layer. The optimized triaxial nanofibers of 669.4 ± 52.43 nm are developed at 7.5 w/w% concentration, 28 kV applied voltage, and 24 cm spinning distance. TiO2 NF@NT structure is obtained through calcination of optimized triaxial nanofibers at 550°C. Subsequently, the morphology of TiO2 NF@NT and its uniform diameter distribution is confirmed through scanning electron microscopy. Fourier‐transform infrared spectroscopy results indicates the formation of TiO2 NF@NT. X‐Rays diffraction pattern peaks also reveals the presence of both anatase and rutile crystalline phases. The presence of only titanium (Ti) and oxygen (O) elements in the TiO2 NF@NT is confirmed through energy dispersive X‐ray spectroscopy. Brunauer–Emmett–Teller analysis indicates that TiO2 NF@NT has a higher specific surface area of ~141.68 m2/g compared with the solid TiO2 nanofiber (~75.31 m2/g). This study can be adopted to develop TiO2 NF@NT for wide range of application.
Polymermörtel‐Klebverbindungen für Holz‐Beton‐Verbundbrücken Teil 1
Authors: Kästner Martin , Rautenstrauch Karl 
Published: February 2021

AbstractLeistungsfähigkeit und Tragverhalten von Holz‐Beton‐Verbundkonstruktionen (HBV) sind entscheidend von der konstruktiven Ausbildung der Verbundfuge abhängig. Die meisten bislang für HBV‐Straßenbrücken entwickelten Verbundlösungen sind durch eine diskontinuierliche Schubübertragung gekennzeichnet, wobei die Schubtragfähigkeit des Holzes nicht optimal ausgenutzt wird. Ziel der im Beitrag vorgestellten Untersuchungen war die Entwicklung von Verbundfugenkonfigurationen mit kontinuierlichem Verbund zwischen Betonfahrbahnplatte und hölzernen Brückenhauptträgern. Zur Vergleichmäßigung der Schubbeanspruchung und zur Vermeidung tragfähigkeitsmindernder Spannungsspitzen im Bereich der Verbundelemente kommen mineralisch gefüllte, toleranzausgleichende Klebmörtel auf Epoxidharzbasis zum Einsatz. Die Beurteilung der Leistungsfähigkeit zweier weiterentwickelter Dübelleistenverbindungen mit Polymermörtelverguss sowie der direkten Polymermörtel‐Klebverbindung von Beton und Holz erfolgte anhand experimenteller und numerischer Untersuchungen. Der vorliegende erste Teil des Beitrags gibt einen Überblick über die entwickelten Verbundfugenkonfigurationen und geeignete Polymermörtel und fokussiert auf die Ergebnisse der Untersuchungen zum Schubtragverhalten. Auf Untersuchungen an Biegeträgern, Bemessungsansätze sowie Empfehlungen für die Ausführung wird im zweiten Teil eingegangen.
Socioeconomic status and concussion reporting: The distinct and mediating roles of gist processing, knowledge, and attitudes
Authors: Ajayi Peter T. , Garavito David M.N. , Reyna Valerie F. 
Published: February 2021

AbstractImproving health outcomes for concussed athletes and others requires self‐reporting symptoms; not reporting risks second‐impact syndrome and death. However, concussions in adolescents and young adults are often underreported. We treat reporting as a risky decision, extending predictions of fuzzy‐trace theory (FTT). We hypothesize that low SES indirectly interferes with the development of cognitive skills that reduce unhealthy risky decision making. Specifically, we expect that SES may be related to intentions to report a concussion because low SES delays development of cognitive gist processing that reduces risk‐taking. Adolescents in high‐school and young adults in college (n = 1211) answered questions about concussion knowledge, concussion attitudes, and cognitive scales based on FTT: categorical thinking and endorsement of gist principles about risk. Overall, for each of the two age groups, and for athletes as well as nonathletes, SES was associated with reporting intentions, and this association was mediated by the three psychological predictors we tested: gist processing, concussion knowledge, and concussion attitudes. Results are consistent with lower SES reducing opportunities for normative cognitive development, the latter characterized by developmental increases in gist processing about risk. Hence, consistent with hypotheses, gist processing, concussion knowledge, and healthier attitudes about concussions were each associated with greater intentions to report concussions. Although educational initiatives currently focus on rote knowledge and healthy attitudes, future interventions to reduce concussion underreporting could benefit from explaining the gist of risk, especially to low SES youth, adapting successful FTT‐based risk‐reduction curricula from other domains.
Sensing and sensitive visualization of latent fingerprints on various surfaces using a versatile fluorescent aggregation‐induced emission‐based coumarin derivative
Authors: Kumar Naveen , Udayabhanu  , Ali Alghamdi Abdulaziz , Basavaraj R.B. , Mahadevan K.M. , Nagaraju G. 
Published: February 2021

AbstractThe marked rise in criminal activity in society has made a difficult task for forensic scientists who aim to track any crime scene effectively, therefore visualization of latent fingerprints (LFPs) plays an increasingly vital role in forensics. In the present report, a highly sensitive solvatochromism, aggregation‐induced emission‐based 2‐(4‐nitrophenyl)‐3H‐benzocoumarin fluorescent dye (CFD) was fabricated using an ultrasonication protocol. The fluorescence properties of the CFD were analyzed using fluorescence spectrophotometer. The CFD produced a greenish yellow emission in solid and fluid states. An in‐depth visualization of LFPs showed detailed ridge patterns under normal and ultraviolet light sources (254 and 365 nm) due to the excellent chemisorption of CFD onto the ridge patterns on the finger. All three types of ridge details were visualized without any background interference when using a simple and quick powder dusting method. Results revealed that, the present fluorescent dye can be used successfully for detection of latent fingerprints (LFPs) on various nonporous substrates surfaces, in organic light‐emitting diodes applications (OLEDs), and for electrochemical sensing.