bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grado de inserción del Aprendizaje Dialógico en escuelas peruanas durante los años 2017 y 2018
Authors: Barrientos Mollo Roberto , Azula Pastor Juan 
Published: August 2021

El presente estudio tuvo como objetivo analizar el grado de inserción del aprendizaje dialógico en siete escuelas de tres regiones del Perú entre los años 2017 y 2018 a estudiantes de 3º a 6º de primaria y de 1º a 5 de secundaria. Estas escuelas fueron seleccionadas a través de un método de muestreo no probabilístico. Los resultados evidenciaron que ocurren mejoras significativas en el nivel de aprendizaje dialógico, principalmente en estudiantes de nivel primaria. La evidencia sugiere que el rol que cumple el proyecto de “Comunidades de Aprendizaje” tiene mayor repercusión en estudiantes más jóvenes.
A Comprehensive Survey for Hadoop Distributed File System
Authors: Merceedi Karwan Jameel , Sabry Nareen Abdulla 
Published: August 2021

In the last few days, data and the internet have become increasingly growing, occurring in big data. For these problems, there are many software frameworks used to increase the performance of the distributed system. This software is used for available ample data storage. One of the most beneficial software frameworks used to utilize data in distributed systems is Hadoop. This software creates machine clustering and formatting the work between them. Hadoop consists of two major components: Hadoop Distributed File System (HDFS) and Map Reduce (MR). By Hadoop, we can process, count, and distribute each word in a large file and know the number of affecting for each of them. The HDFS is designed to effectively store and transmit colossal data sets to high-bandwidth user applications. The differences between this and other file systems provided are relevant. HDFS is intended for low-cost hardware and is exceptionally tolerant to defects. Thousands of computers in a vast cluster both have directly associated storage functions and user programmers. The resource scales with demand while being cost-effective in all sizes by distributing storage and calculation through numerous servers. Depending on the above characteristics of the HDFS, many researchers worked in this field trying to enhance the performance and efficiency of the addressed file system to be one of the most active cloud systems. This paper offers an adequate study to review the essential investigations as a trend beneficial for researchers wishing to operate in such a system. The basic ideas and features of the investigated experiments were taken into account to have a robust comparison, which simplifies the selection for future researchers in this subject.
According to many authors, this paper will explain what Hadoop is and its architectures, how it works, and its performance analysis in a distributed systems. In addition, assessing each Writing and compare with each other.
Pseudomonas aeruginosa Positivity and Sensitivity in Invasive Bloodstream Infections Using Automated Bactec in Tertiary Care Teaching Hospital of North India
Authors: Katoch Pankaj , Roach Vipin 
Published: August 2021

Background: Pseudomonas aeruginosa is one of the most commonly encountered gram-negative aerobic bacilli in the differential diagnosis of several probable hospital-acquired infections. Hence, the present study is designed to determine the Pseudomonas positivity and sensitivity in Invasive bloodstream infections using automated Bactec systems as the Antibiotic Sensitivity Profiles differ from one clinical setting to another.
Material and Methods: All the blood culture samples received in the Department of Microbiology for culture by Bactec Bd fx from July 2015 to June 2016 were included in the study. The blood culture was observed in the Bactec bd fx system for at least 5 days before they are reported as sterile.
Results: Among the total 1275 cultures which were positive for bacteria, 931(73.02%) were positive for gram-negative bacteria. Among the total of 931culture which were positive for gram-negative bacteria, Pseudomonas aeruginosa was isolated in 120(12.89%) cultures. Maximum was found in the age group of 0-1 years 33(27.50%) followed by 19-45 years 26(21.67%). Pseudomonas spp isolates were 100.00% sensitive to Colistin followed by Levofloxacin 84.44%, Piperacillin Tazobactum 82.50%, PB 77.50%, Amikacin 75.00%, Cefepime 75.00% while Pseudomonas spp isolates were 90% resistant to Ampicillin followed by Ceftazidime clavulanic acid 82.64% and Aztreonam 70.31%.
Conclusion: Pseudomonas aeruginosa is one of the most common organisms among Gram-Negative isolates and the most commonly isolated in the neonate and infant age group. All the Pseudomonas isolates showed maximum sensitivity to Colistin followed by Levofloxacin, Piperacillin Tazobactum, Amikacin while they were most resistant to Ampicillin followed by Ceftazidime clavulanic acid and Aztreonam. Some alternative novel techniques need to be developed to counter the increasing menace of antibiotic resistance in this particular pathogenic bacteria
Seasonal Growth, Physiological and Biochemical Characterization of Five Prunus spinosa Ecotypes
Authors: Wanjiku James Gacheru , Bohne Heike 
Published: August 2021

Prunus spinosa species is distributed across wide range of geographical areas which are subject to climatic, edaphic factors and long-term divergent selection. This could lead to local adaptation hence ecotypes in terms of morphological, physiologically and or biochemical inclination to their local environment. To investigate whether the species (Prunus spinosa) has been influenced by their local environmental conditions and whether populations (ecotypes) are adapted to local conditions, cuttings from different demarcated areas of origin in Germany and Italy were sourced and cultivated optimally in common container area. Growth, bud sprout and bud set were evaluated in spring, summer and autumn respectively. Soluble sugars (Glucose, fructose, sucrose and starch), N, P, K, and proline concentrations were analysed in spring and autumn for three years. The findings indicated that plants grown from different locations mostly differed in N, P, K, soluble sugars and starch in spring. Nonetheless, these geographic variations were hardly observed either in summer or in autumn. On phenology, German populations did not differ at all in phenology (flushing and growth cessation) while the Italian population always sprouted earlier and ceased growth later. The results indicate that the German populations are not differentiated by climatic variations across latitude or altitude. In contrast the Italian population is differentiated from German population Brandenburg mostly by latitudinal differentiation. Nevertheless, their inherent ability to sprout earlier and late growth cessation might expose the population to frequent frost damage when transplanted to more northern latitude.
Comparative Analysis of Differentially Expressed Genes in Oral Leukoplakia and Oral Submucous Fibrosis Using Bioinformatics Approach
Authors: Budakoti Akansha , More Chandramani B. , Seth Avinash K. , Sharma Priyanka 
Published: August 2021

Aims and Objectives: There is lack of understanding of distinct molecular pathways and associated gene mediators of the Potentially malignant disorders of the oral cavity (OPMD), such as Leukoplakia and Oral sub mucous fibrosis. This microarray data analysis aims to highlight common and distinct gene signatures by identifying the differentially expressed genes and the pathways in which they participate to help researchers & clinicians to distinctly characterize the Oral Leukoplakia and Oral Submucous Fibrosis disease conditions for developing appropriate treatment strategies
Methods: Gene Expression Omnibus datasets of Oral leukoplakia GSE85195 (OL) and Oral submucous fibrosis (OSMF) GSE64216 were analyzed using GEO2R package (using Log 2 fold change; false discovery rate < 0.05). The lists of differentially expressed genes of both datasets were analyzed for common and distinct members. These were then submitted to Database for Annotation, Visualization and Integrated Discovery (DAVID) for gene set enrichment analysis and functional annotation, to identify enriched Gene Ontology terms and KEGG pathways (Fisher's Exact Test for P-value < 0.05).
Results: In total 1107 in OL, 607 in OSMF and 143 common differentially expressed genes in both OL and OSMF were identified. The gene set enrichment analysis by DAVID revealed 26% integral component of membrane, 20% extracellular region and 14% nucleus as cellular components and molecular functions. The distinct gene signatures and altered biological pathways reported here clearly distinguish molecular profiles of both OL and OSMF, which may help to identify potential drug targets for developing and designing new treatment strategies in future.
Investigation of Drug-Excipient Compatibility Studies Using Validated RP-HPLC Method for Azelnidipine and Telmisartan Tablets
Authors: Kumar Manish , Chandra Umesh , Garg Arun , Gupta Pankaj 
Published: August 2021

Aims: The Drug-Excipient compatibility testing was conducted at an early product development stage to determined that Excipients were compatible with drugs used in formulation and to distinguish as many degradation products as possible using validated gradient RP-HPLC method.
Study Design: Drug-Excipient Compatibility study was conducted in glass vials at different stability conditions namely, at 300C + 20C/75% + 5% RH, 400C + 20C/ 75% + 5% RH for 04 weeks and another set of closed vials were stored in stability chamber at temperature 600C + 20C for 02 weeks.
Methodology: Samples were analyzed by validated RP-HPLC method using Inertsil C-18 Column 150 × 4.6 mm ×5 µm, column oven temperature 40°C, flow rate 1.5 mL/min, Injection volume 10 µL with run time 12.0 minutes at 254 nm using Acetonitrile and buffer as mobile phase in gradient mode.
Results: The developed method meets all system suitability parameters and found specific to determine the drug in the presence of Excipient as no interference was observed at the Retention time (Rt) of analyte.
Conclusion: There was no physical and chemical incompatibility observed with Drug-Excipient and did not observe significant increase in the related substances.
The Association of Adiponectin and AdipoR1 Polymorphism rs1342387 in Some Obesity-related Cancers in Kurdistan Iraq
Authors: Khaleel Mahmood , Al-Ali Shereen , Habeeb Baker Shalal 
Published: August 2021

Background: Adiponectin (APN) is a novel hormone produced mainly by white adipose tissue that contribute to various physiological functions. APN has been related to cancer development specially the ones related to obesity such as breast cancer (BC) and colorectal cancer (CRC). Therefore, it also has been related body mass index (BMI). This study aims to investigate the role of APN and AdipoR1 polymorphism rs1342387 in some obesity-related cancer patients living in Erbil province (Kurdistan-Iraq).
Method: The study includes 82 subjects (66 cancer patients, 16 healthy controls) from 4 medical facilities in Erbil, all participants were subjected to a questionnaire and signed a consent form before taking the samples. The serum level of APN was estimated by ELISA and the AdipoR1 polymorphism (rs1342387) was detected by RFLP-PCR.
Results: The results showed that the prevalence of BC cases were more than CRC cases. Furthermore, females were the dominant sex in BC. Moreover, the level of APN was significantly decreased in obesity-related cancer groups (BC, CRC) in compare to HC. Regarding APN correlation with BMI the results showed a weak non-significant negative correlation. The attempt to investigate the genotype of Kurdish people showed the frequency of GG genotype among Kurdish people but the recessive AA genotype showed more effects on decreasing the level of APN despite the non-significant results.
Conclusion: This study is the first to investigate AdipoR1 polymorphism and its correlation to obesity-related cancers in Kurdistan-Iraq and although GG was the more frequent genotype, AA was more effective on APN levels in obesity-related cancers.
Evolving Devil's Staircase Magnetization from Tunable Charge Density Waves in Nonsymmorphic Dirac Semimetals
Authors: Singha Ratnadwip , Salters Tyger H. , Teicher Samuel M. L. , Lei Shiming , Khoury Jason F. , Ong N. Phuan , Schoop Leslie M. 
Published: August 2021

AbstractWhile several magnetic topological semimetals have been discovered in recent years, their band structures are far from ideal, often obscured by trivial bands at the Fermi energy. Square‐net materials with clean, linearly dispersing bands show potential to circumvent this issue. CeSbTe, a square‐net material, features multiple magnetic‐field‐controllable topological phases. Here, it is shown that in this material, even higher degrees of tunability can be achieved by changing the electron count at the square‐net motif. Increased electron filling results in structural distortion and formation of charge density waves (CDWs). The modulation wave‐vector evolves continuously leading to a region of multiple discrete CDWs and a corresponding complex “Devil's staircase” magnetic ground state. A series of fractionally quantized magnetization plateaus is observed, which implies direct coupling between CDW and a collective spin‐excitation. It is further shown that the CDW creates a robust idealized nonsymmorphic Dirac semimetal, thus providing access to topological systems with rich magnetism.
Automatically Adaptive Ventilated Metamaterial Absorber for Environment with Varying Noises
Authors: Tian Hongxing , Xiang Xiao , He Keming , Liu Chuanyu , Hou Suxia , Wang Shuxia , Huang Yingzhou , Wu Xiaoxiao , Wen Weijia 
Published: August 2021

AbstractAn automatically adaptive metamaterial sound absorber is designed, which can absorb tunable low‐frequency (<500 Hz) sounds under ventilated conditions by designing a feedback circuit to actively detect the noise signals and adjust the sliders on the reconfigurable absorbers. The automatically adaptive ventilated absorber provides an intelligent route to adapt for different low frequencies, through adjusting the sound absorption units directly in accordance with the external environment while retaining high‐efficiency absorption and ventilation. The intelligent sound absorber is demonstrated experimentally and the effective model of coupled lossy oscillators is employed to understand its mechanism. In the future, the absorber that is fabricated can be adjusted to adapt for different working frequencies in stunning applications such as ventilated smart windows, which not only effectively solves the influence of external noise but also provides a fresh and bright working environment. The automatically adaptive absorber should also find promising applications in ducts, where the frequencies of noises can vary time by time, and it is often difficult and inaccurate to manually tune an absorber in such scenarios.
Deep intronic variant in the ARSB gene as the genetic cause for Maroteaux–Lamy syndrome (MPS VI)
Authors: Marek‐Yagel Dina , Eliyahu Aviva , Veber Alvit , Shalva Nechama , Philosoph Amit Mary , Barel Ortal , Javasky Elisheva , Pode‐Shakked Ben , Loewenthal Neta , Anikster Yair , Staretz‐Chacham Orna 
Published: August 2021

AbstractMaroteaux–Lamy syndrome (MPS‐VI) is a rare autosomal‐recessive disorder with a wide spectrum of clinical manifestations, ranging from an attenuated to a rapidly progressive disease. It is caused by variants in ARSB, which encodes the lysosomal arylsulfatase B (ARSB) enzyme, part of the degradation process of glycosaminoglycans in lysosomes. Over 220 variants have been reported so far, with a majority of missense variants. We hereby report two siblings of Bedouin origin with a diagnosis of MPS‐VI. Western blots in patient fibroblasts revealed total absence of ARSB protein production. Complete sequencing of the coding region of ARSB did not identify a candidate disease‐associated variant. However, deep sequencing of the noncoding region of ARSB by whole genome sequencing (WGS) revealed a c.1142+581A to G variant. The variant is located within intron 5 and fully segregated with the disease in the family. Determination of the genetic cause for these patients enabled targeted treatment by enzyme replacement therapy, along with appropriate genetic counseling and prenatal diagnosis for the family. These results highlight the advantage of WGS as a powerful tool, for improving the diagnostic rate of rare disease‐causing variants, and emphasize the importance of studying deep intronic sequence variation as a cause of monogenic disorders.
A novel rat tail disc degeneration model induced by static bending and compression
Authors: Ji Yichao , Zhu Pengfei , Zhang Linlin , Yang Huilin 
Published: August 2021

AbstractBackgroundA new rat tail intervertebral disc degeneration model was established to observe the morphologic and biologic changes of static bending and compression applied to the discs.MethodsIn total, 20 Sprague‐Dawley rats with similar weight were randomly divided into 4 groups. Group 1 served as a control group for a baseline assessment of normal discs. Group 2 underwent a sham surgery, using an external device to bend the vertebrae of coccygeal 8‐10. Groups 3 and 4 were the loaded groups, and external devices were instrumented to bend the spine with a compression level of 1.8 N and 4.5 N, respectively. Magnetic resonance imaging (MRI), histological, and quantitative real‐time PCR (qRT‐PCR) analysis were performed on all animals on day 14 of the experiment.ResultsMagnetic resonance imaging and histological results showed that the changes of intervertebral disc degeneration increased with the size of compression load. Some architecture disorganizations in nucleus pulposus and annulus fibrosus were found on both of the convex and concave side in the groups of 1.8 N and 4.5 N. An upregulation of MM‐3, MM‐13, and collagen 1‐α1 mRNA expression and a downregulation of collagen 2‐α1 and aggrecan mRNA expression were observed in the sham and loading groups. Significant changes were found between the loading groups, whereas the sham group showed similar results to the control group.ConclusionsStatic bending and compression could induce progressive disc degeneration, which could be used for biologic study on disc degeneration promoted by static complex loading.
Interaction between Preterm White Matter Injury and Childhood Thalamic Growth
Authors: Cayam‐Rand Dalit , Guo Ting , Synnes Anne , Chau Vann , Mabbott Connor , Benavente‐Fernández Isabel , Grunau Ruth E. , Miller Steven P. 
Published: August 2021

ObjectiveThe purpose of this study was to determine how preterm white matter injury (WMI) and long‐term thalamic growth interact to predict 8‐year neurodevelopmental outcomes.MethodsA prospective cohort of 114 children born at 24 to 32 weeksʼ gestational age (GA) underwent structural and diffusion tensor magnetic resonance imaging early in life (median 32 weeks), at term‐equivalent age and at 8 years. Manual segmentation of neonatal WMI was performed on T1‐weighted images and thalamic volumes were obtained using the MAGeT brain segmentation pipeline. Cognitive, motor, and visual‐motor outcomes were evaluated at 8 years of age. Multivariable regression was used to examine the relationship among neonatal WMI volume, school‐age thalamic volume, and neurodevelopmental outcomes.ResultsSchool‐age thalamic volumes were predicted by neonatal thalamic growth rate, GA, sex, and neonatal WMI volume (p < 0.0001). After accounting for total cerebral volume, WMI volume remained associated with school‐age thalamic volume (β = −0.31, p = 0.005). In thalamocortical tracts, fractional anisotropy (FA) at term‐equivalent age interacted with early WMI volume to predict school‐age thalamic volumes (all p < 0.02). School‐age thalamic volumes and neonatal WMI interacted to predict full‐scale IQ (p = 0.002) and adverse motor scores among those with significant WMI (p = 0.01). Visual‐motor scores were predicted by thalamic volumes (p = 0.04).InterpretationIn very preterm‐born children, neonatal thalamic growth and WMI volume predict school‐age thalamic volumes. The emergence at term of an interaction between FA and WMI to impact school‐age thalamic volume indicates dysmaturation as a mechanism of thalamic growth failure. Cognition is predicted by the interaction of WMI and thalamic growth, highlighting the need to consider multiple dimensions of brain injury in these children. ANN NEUROL 2021;90:584–594
Synthesis and characterization of tailor‐made N‐vinylpyrrolidone copolymers and their blend membranes with polyvinyl alcohol for bioethanol dehydration by pervaporation
Authors: Angelini Alessandro , Fodor Csaba , Leva Luigi , Car Anja , Dinu Ionel Adrian , Yave Wilfredo , Meier Wolfgang 
Published: August 2021

AbstractTailor‐made poly(N‐vinylpyrrolidone‐co‐(2‐[dimethylamino]ethyl methacrylate)) P(NVP‐co‐DMAEMA) and poly(N‐vinylpyrrolidone‐co‐N‐vinylimidazole) P(NVP‐co‐PNVIm) with defined monomer molar ratio are synthesized via free radical polymerization. The random copolymers are fully characterized and then blended with polyvinyl alcohol (PVA) to investigate their chemical and thermal properties as membrane materials. Composite membranes are further prepared from the PVA/copolymer blends on a porous support, which are evaluated in terms of separation performance for the dehydration of ethanol by pervaporation. The membranes prepared from the blends exhibit up to four times higher water permeances than pristine PVA membrane, albeit the selectivity is slightly lower. Nevertheless, the membranes from blends with a ratio of 95:5 (PVA/copolymer) show improved selectivity and higher permeance values compared to the commercial PERVAP™ 4155–80, especially the blends composed by the copolymers of coPDMAEMA60 and coPDMAEMA20. The membrane prepared from the blend containing the homopolymer coPDMAEMA100 exhibits the highest water/ethanol selectivity and shows stable separation performance throughout the whole long‐term stability test. Thus, this study demonstrated that by synthesizing tailored copolymers (rather using the commercial ones) and blending with PVA, the separation performance of membranes can be significantly improved and tuned for specific dehydration processes.
Nachträgliche Verbundverankerung von Stabspanngliedern – Entwicklung eines Verankerungssystems für quer vorgespannte Fahrbahnplatten
Authors: Sanio David , Alawieh Hussein , Bomholt Frederik , von Daake Henning , Prenting Adele , Mark Peter 
Published: August 2021

AbstractFür den Teilrückbau von Beton‐ oder Verbundbrücken wird oftmals die quer vorgespannte Fahrbahnplatte in Längsrichtung durchschnitten. Während eine Hälfte durch einen Neubau ersetzt wird, bleibt der Verkehr auf dem halben Bestandsüberbau aufrechterhalten. Aus statischen Gründen kann es erforderlich werden, die Quervorspannung in der Fahrbahnplatte über einen Zeitraum von wenigen Jahren zu erhalten. Der Beitrag stellt dazu ein Verankerungskonzept vor, das im Rahmen des Ersatzneubaus einer Autobahnbrücke in Verbundbauweise entwickelt wurde. Dabei verankert sich das glatte Stabspannglied über Verbund in einem neu eingebrachten Betonelement. Das System wurde in einem mehrstufigen experimentellen Programm entwickelt und durch theoretische Betrachtungen zur Verbundverankerung begleitet. Dabei wurden neben der statischen Verankerung auch zyklische Belastungen, Verbundkriechen und die Rissbildung untersucht. Die Untersuchungen zeigen, dass sich die Stabspannglieder (St80/105, ∅26 mm) auf einer Länge von 1,45 m vollständig in dem verwendeten hochfesten Vergussbeton verankern. Ohne Betrachtung rechnerischer Sicherheiten erfolgt die wesentliche Kraftübertragung auf wenigen Dezimetern. Zudem behandelt der Beitrag die baupraktische Umsetzung und Überwachung sowie spezifische zu beachtende Randbedingungen.