bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Responses of Metabolically Active Limnospira indica Strain PCC 8005 Exposed to γ-Radiation during Its Lifecycle
Authors: Yadav Anu , Maertens Laurens , Meese Tim , Van Nieuwerburgh Filip , Mysara Mohamed , Leys Natalie , Cuypers Ann , Janssen Paul Jaak 
Published: August 2021

Two morphotypes of the cyanobacterial Limnospira indica (formerly Arthrospira sp.) strain PCC 8005, denoted as P2 (straight trichomes) and P6 (helical trichomes), were subjected to chronic gamma radiation from spent nuclear fuel (SNF) rods at a dose rate of ca. 80 Gy·h−1 for one mass doubling period (approximately 3 days) under continuous light with photoautotrophic metabolism fully active. Samples were taken for post-irradiation growth recovery and RNA-Seq transcriptional analysis at time intervals of 15, 40, and 71.5 h corresponding to cumulative doses of ca. 1450, 3200, and 5700 Gy, respectively. Both morphotypes, which were previously reported by us to display different antioxidant capacities and differ at the genomic level in 168 SNPs, 48 indels and 4 large insertions, recovered equally well from 1450 and 3200 Gy. However, while the P2 straight type recovered from 5700 Gy by regaining normal growth within 6 days, the P6 helical type took about 13 days to recover from this dose, indicating differences in their radiation tolerance and response. To investigate these differences, P2 and P6 cells exposed to the intermediate dose of gamma radiation (3200 Gy) were analyzed for differential gene expression by RNA-Seq analysis. Prior to batch normalization, a total of 1553 genes (887 and 666 of P2 and P6, respectively, with 352 genes in common) were selected based on a two-fold change in expression and a false discovery rate FDR smaller or equal to 0.05. About 85% of these 1553 genes encoded products of yet unknown function. Of the 229 remaining genes, 171 had a defined function while 58 genes were transcribed into non-coding RNA including 21 tRNAs (all downregulated). Batch normalization resulted in 660 differentially expressed genes with 98 having a function and 32 encoding RNA. From PCC 8005-P2 and PCC 8005-P6 expression patterns, it emerges that although the cellular routes used by the two substrains to cope with ionizing radiation do overlap to a large extent, both strains displayed a distinct preference of priorities.
Effect of Nb5+ and In3+ Ions on Moisture Sensitivity of Electrospun Titanium/Tungsten Oxide Nanostructures: Microstructural Characterization and Electrical Response
Authors: Silva Georgenes M. G. , Leão Victor N. S. , Pereira Michel F. G. , Faia Pedro M. , Araújo Evando S. 
Published: August 2021

In this work, Nb5+ and In3+ ions were used as dopants in titanium/tungsten oxide nanostructures that are produced by the electrospinning and sintering process, for relative humidity (RH) detection. The microstructural properties were investigated by SEM, EDS, XRD, Raman and FTIR techniques. The electrical response characterization of the samples was performed by electrical impedance spectroscopy in the range of 400 Hz to 40 MHz, at 20 °C. The sensors sensitivity to moisture was evaluated in terms of the impedance variations to RH (10–100%). The combined analysis of the microstructural characterization results confirmed the surface interaction between the oxides and the ions incorporation in Ti crystal lattice. All the studied sensors showed a conduction transition from p- to n-type at around 30–40% RH: besides, they also displayed better sensitivity to moisture than those obtained in a previous work using titanium/tungsten combination using a different fabricationn route. The impedance modulus variation up to 1.1 and 1.3 orders of magnitude for the 4 wt % niobium and indium doped samples, respectively. The results are directly associated with the microstructure and alternative preparation process.
Molecular Characterization of Corynebacterium pseudotuberculosis Isolated over a 15-Year Period in Switzerland
Authors: Schlicher Jessica , Schmitt Sarah , Stevens Marc J. A. , Stephan Roger , Ghielmetti Giovanni 
Published: August 2021

Corynebacterium pseudotuberculosis biovar Ovis is the etiological agent of the contagious and chronic disease caseous lymphadenitis (CLA) in sheep and goats. The economic impact of CLA in Switzerland remains largely unknown, and the transmission modalities, as well as the genetic diversity of circulating strains, are poorly understood. This work presents further characterization data for 215 C. pseudotuberculosis isolates from sheep, goats and a dromedary originating from Switzerland and the Principality of Liechtenstein, collected over a 15-year period. The isolates were classified into the two biovars Ovis and Equi, analyzed for the presence of the diphtheria-like toxin gene and characterized using MLSA. All sheep and goat isolates were classified as C. pseudotuberculosis biovar Ovis. The isolate from a dromedary was classified as biovar Equi. No isolates harboring the diphtheria-like toxin gene were detected. Phylogenetic analysis of the concatenated sequences of four genes revealed the existence of 24 clusters. There was no correlation between MLSA sequence types, year of isolation and the geographical origin of the isolates. These findings confirm the presence of several MLSA sequence types in the study area and over a 15-year period. Moreover, no sheep- and goat-specific MLSA sequence types were found.
PERANCANGAN PROTOTYPE APLIKASI PEMESANAN PERCETAKAN MENGGUNAKAN ALGORITMA WHATSAPP GATEWAY PADA PT MONICA INTERMEDIA GRAFIKA
Authors: Ahmad  
Published: August 2021

The printing purchase order (PO) information system uses the WhatsApp gateway, which aims to provide PO Printing and customer invoicing services. This time, PT MIG is engaged in graphics, which already has regular customers and print routines. The problem that often occurs is the management of customer transactions, where customers make print orders using WhatsApp Messenger more often. So that the admin has difficulty recording it, because the message is deleted or forgot to write it down. The design of this system uses UML (Unified Modeling Language) tools with the Prototype model.
Keywords : Prototype, PO Printing, Whatsapp Gateway.
RESEARCH IN POSSIBILITY OF RATIONAL USE OF ANTIHISTAMINES AMONG ELDERLY PEOPLE FROM THE PERSPECTIVE OF SAFETY AND ECONOMIC ACCESSIBILITY
Authors: Лесонен А. С. , Виноградова И. А. , Лоскутова Е. Е. 
Published: August 2021

В работе исследована возможность рационального применения антигистаминных лекарственных препаратов у пожилых потребителей с учетом критериев Бирса и STOPP/START -критериев, использование которых способно предотвратить назначение фармакотерапии пожилым пациентам ненадлежащим образом. Выявлены антигистаминные препараты, использование которых нежелательно при лечении потребителей старших возрастных групп. Исследована экономическая доступность рекомендованных антигистаминных препаратов для лиц 65 лет и старше.
The article is devoted to the research in possibility of rational use of antihistamines among elderly people taking into account Beers criteria and STOPP/START criteria which can prevent irrational use of medicines by senior consumers. Antihistamines that are not recommended for elderly people treatment were identiﬁed. Economic accessibility of antihistamines allowed for use among people aged 65 and over was evaluated.
PORTABLE TELEMEDICAL COMPLEX USAGE PERSPECTIVES FOR MEDICAL CARE OF ELDERLY AND SENILE PATIENTS WITH CEREBROVASCULAR PATHOLOGY
Authors: Сайганов С.А. , Мазуров В.И. , Голдобин В.В. , Лобзин С.В. , Клочева Е.Г. , Головкин В.И. 
Published: August 2021

В статье отражены перспективы оказания медицинской помощи пациентам пожилого и старческого возраста с цереброваскулярной патологией с использованием портативного телемедицинского комплекса. Проведен анализ телемедицинского взаимодействия врач-консультант-пациент для оказания медицинской помощи, обсуждены критерии выбора медицинских приборов в составе телемедицинского комплекса, организационно-правовые аспекты передачи, хранения и доступа к медицинской информации, приведены важные клинические особенности цереброваскулярной патологии у пациентов старших возрастных групп, определяющие необходимость привлечения высококвалифицированных специалистов, а также возможности использования разрабатываемого портативного комплекса.
The article discusses perspectives of medical care in elderly and senile patients with cerebrovascular pathology with portable telemedical complex use. Analysis of telemedical cooperation physician-consultant-patient and discussion of medical equipment criteria for telemedical complex selection and organizational together with legal issues of medical data transfer, storage and access were performed. The important clinical features of cerebrovascular pathology in elderly patients were presented, which determined necessity of highly qualified medical specialist involvement in management of such patients. The opportunities of portable medical complex usage were discussed.
COMPLEX ASSOCIATION ANALYSIS OF ANTIOXIDANT GENES POLYMORPHIC DNA-MARKERS WITH AGE IN THE ETHNIC GROUP OF ABKHAZIANS
Authors: Эрдман В.В. , Матуа А.З. , Насибуллин Т.Р. , Туктарова И.А. , Горухчиева Ф.А. , Трапш Х.З. , Амаба С.Т. , Ахуба Л.О. , Смыр С.Д. , Данилко К.В. , Викторова Т.В. 
Published: August 2021

Впервые в этнической группе абхазов выполнен анализ ассоциаций полиморфных ДНК-маркеров генов антиоксидантной системы CAT (rs1001179), MSRA (rs10098474), GPX1 (rs1050450), GSR (rs1002149), GSTP1 (rs1695), SOD1 (rs2070424), SOD2 (rs4880), PON1 (rs662), PON2 (rs7493) с возрастом. С использованием ROC-анализа и логистической регрессии установлено, что спектр частот аллелей и генотипов полиморфных маркеров генов PON1 и GSTP1 меняется на протяжении всего исследуемого возрастного периода (21 107 лет); распределение частот аллелей и генотипов по полиморфным маркерам генов CAT и SOD2 изменяется на рубеже 60 лет. Методом Монте-Карло марковскими цепями определены мультилокусные генетические маркеры долголетия. У лиц 60-107 лет статистически значимо повышена частота встречаемости паттернов GSTP 1* G/G + PON 1* G ( OR =6,59, PFDR =0,018) и GSTP 1* G/G + SOD 1 *A ( OR =3,4, PFDR =0,041); аллель GSTP 1* A в разных комбинациях с аллелями PON 1*A, PON2 * C и CAT * C встре чается реже (OR=0,3, PFDR<0,05).
For the first time in the ethnic group of Abkhazians, the association analysis of polymorphic DNA-markers of the antioxidant genes CAT ( rs 1001179), MSRA ( rs 10098474), GPX 1 ( rs 1050450), GSR ( rs 1002149), GSTP 1 ( rs 1695), SOD 1 ( rs 2070424), SOD 2 ( rs 4880) , PON 1 ( rs 662), PON 2 ( rs 7493) with age was performed. Using ROC-analysis and logistic regression, it was found that the spectrum of alleles and genotypes frequencies of PON 1 and GSTP 1 genes polymorphic markers change throughout the studied age period (21-107 years old); the distribution of allele and genotype frequencies of CAT and SOD 2 genes polymorphic markers changes within the age of 60 years. Multilocus genetic markers of longevity were determined by the Monte Carlo Markov chain method. Among persons in the age range 60-107 years, the frequency of observation of the patterns GSTP 1* G/G + PON 1* G ( OR =6,59, P FDR=0,018) and GSTP 1* G/G + SOD 1 *A ( OR =3,4, P FDR=0,041) is statistically significantly increased; the GSTP 1* A allele in various combinations with the PON 1* A , PON 2* C and CAT * C alleles are less common ( OR =0,3, P FDR<0,05).
Energy transfer and luminescence enhancement of Cu2+ ions in polyvinyl pyrrolidone caped ZnS:Cu nanoparticles
Authors: Thi Tran Minh , Ben Pham Van , Thai Dang Van , Van Bui Hong 
Published: August 2021

Abstract
Cu doped ZnS nanoparticles (ZnS:Cu) were synthesized by the co-precipitation method from Zn(CH3COO)2 0,1 M, Cu(CH3COO)2 0,1 M and Na2S 0,1 M solutions. Then they were coated by polyvinyl pyrrolidone (PVP) with different masses from 0.1 to 0.8 g. The photoluminescence excitation (PLE) spectra of 525 nm green photoluminescence (PL) band using xenon lamp shows the 330 nm peak and prominent peaks at 450, 470, 480 nm. The 330 nm peak is attributed by characterizes of nearshore absorption displacement of the ZnS crystal and the 450, 470, 480 nm peaks are involved in the adsorption displacement of Cu2+ (3d9) ions in the ZnS:Cu nanoparticles. The PVP coating hardly changes the crystal structure, the average crystal size, the morphology, the position of PL and PLE peaks that only increase their intensity. This enhancement is due to the transfer of excitation energy from PVP to Cu2+ ions (3d9) through the –C=O–M2+ (M2+: Zn2+, Cu2+) coordination bonds between the O atoms of the C=O group and ions Zn2+, Cu2+ on the surface of the nanoparticles.
Distribusi Medan Listrik di Kompartemen Busbar Gas Insulated Switchgear (GIS) Menggunakan Charge Simulation Method
Authors: Rahmat Saepul , Dewi Riyani Prima 
Published: August 2021

Penelitian ini bertujuan untuk mengilustrasikan distribusi medan listrik di kompartemen busbar tipe gas insulated switchgear (GIS). Gas Insulated Substation (GIS) merupakan rangkaian peralatan gardu induk yang terpasang di dalam sebuah metal enclosure dan diisolasi oleh gas bertekanan yaitu Sulfur Hexafluoride (SF6). Dalam simulasi ini, diasumsikan titik referensi berada di sekitar contact pin busbar, dan titik muatan buatan berada disekitar kompartemen busbar. Simulasi dilakukan dengan menentukan titik referensi dan titik muatan bantuan untuk menghitung nilai muatan yang akan dicari yaitu contact pin. Titik muatan buatan ini terletak disembarang titik disekitar kompartemen busbar GIS dan akan dihitung nilai muatannya melalui metode simulasi muatan (charge simulation method) dengan bantuan komputasi Matlab
Violência obstétrica: fatores desencadeantes e medidas preventivas de enfermagem
Authors: Vitorino de Sousa Maria Patrí­cia , Alves dos Santos Lohany Stéfhany , Ferreira Caldas Geovanna Renaissa , De Assis Moura Batista Francisco , Lopes da Silva Cicero Rafael 
Published: August 2021

OBJETIVO: Caracterizar os fatores que ocasionam a violência obstétrica e a importância da enfermagem no desenvolvimento de medidas preventivas. MÉTODOS: Trata-se de uma revisão sistemática da literatura com metassí­ntese, com utilização do protocolo PRISMA. Realizou-se a pesquisa referida na fonte de busca: Biblioteca Virtual em Saúde (BVS) e nas bases de dados: SCIELO e LILACS, apresentando uma totalidade de 61 documentos. Após estabelecimento e aplicação dos critérios de inclusão: artigos disponí­veis gratuitos, publicados entre 2015 a 2020, em lí­ngua portuguesa, inglesa e espanhola e exclusão: não apresentassem í temática, repetitivos, dissertações e resumos, resultando em um total de 10 artigos. RESULTADOS: O processo do parto é um acontecimento repleto de possí­veis equí­vocos, condutas dolorosas e negligências, que podem gerar a violência obstétrica causando traumas fí­sicos e psicológicos irreversí­veis. CONCLUSíO: Por meio desse estudo buscou destacar a importância de minimizar as praticas abusiva, com o uso de estratégias que efetivem programas e polí­ticas voltadas ao binômio mãe-filho.
PENGEMBANGAN DESA WISATA SEBALOR MENJADI DAERAH TUJUAN WISATA
Authors: Andri Wahyudi  , Fachrul Firdaus  
Published: August 2021

Pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata (DTW) tidak terlepas dari kemauan serta keterlibatan/ partisipasi masyarakat yang ada di desa tersebut secara langsung maupun tidak langsung. Penelitian ini bertujuan untuk memotret kemauan, keterlibatan/ partisipasi masyarakat dalam pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata. Rumusan masalah dalam Penelitian ini adalah : Bagaimana Pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata (DTW) dan juga ingin mengungkap beberapa hal yang dimungkinkan dapat menjadi faktor pendorong dan penghambat Pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata (DTW) di kawasan Kecamatan Bandung Kabupaten Tulungagung. Metode penelitian dalam penelitian ini termasuk metode deskreptif sedangkan jenis penelitiannya adalah termasuk dalam penelitian kualitatif. Pengumpulan data dilakukan dengan menggunakan metode observasi, wawancara, dan dokumentasi. Subjek dalam penelitian ini adalah Pemerintah Desa Sebalor, Masyarakat Desa Sebalor, Pengunjung Kali Mas dan Watu Gedong. Selanjutnya analisa data dalam penelitian ini dilakukan dengan menggunakan analisa kualitatif dengan langkah-langkah reduksi data, penyajian data dan penarikan kesimpulan. Keabsahan data dalam penelitian ini meliputi 1) uji kredibility, 2) uji transferability, 3) uji dependability, 4) uji konfirmability.
EVALUATING PANDEMIC LED PANIC BUYING IN RETAIL SECTOR OF PAKISTAN
Authors: Asma Asma Basit , Lubna Lubna Maroof , Amna Amna Aslam 
Published: August 2021

ABSTRACT

Purpose: The study sought to evaluate the unique panic buying behavior of consumers to gain an understanding of the factors leading to this type of consumer behavior and its implications for retail marketers and policymakers.
Bimanual thumb-index finger indications of noncorresponding extents
Authors: Landwehr Klaus 
Published: August 2021

AbstractTwo experiments tested a prediction derived from the recent finding that the Oppel-Kundt illusion – the overestimation of a filled extent relative to an empty one – was much attenuated when the empty part of a bipartite row of dots was vertical and the filled part horizontal, suggesting that the Horizontal-vertical illusion – the overestimation of vertical extents relative to horizontal ones – only acted on the empty part of an Oppel-Kundt figure. Observers had to bimanually indicate the sizes of the two parts of an Oppel-Kundt figure, which were arranged one above the other with one part vertical and the other part tilted -45°, 0°, or 45°. Results conformed to the prediction but response bias was greater when observers had been instructed to point to the extents’ endpoints than when instructed to estimate the extents’ lengths, suggesting that different concepts and motor programs had been activated.
Vaccination of the older adults against the new coronavirus infection SARS-CoV-2 (COVID-19). Position of the Russian Association of Gerontologists and Geriatricians
Authors: Editorial Article 
Published: August 2021

Пациенты пожилого и старческого возраста относятся к группе наиболее высокого риска тяжелого течения и неблагоприятного исхода COVID-19. COVID-19 диспропорционально опасен для лиц пожилого и старческого возраста: на долю пациентов 65 лет и старше в мире приходится 90% всех смертей от COVID-19. Нередко COVID-19 имеет бессимптомное течение, ввиду чего более молодые люди могут заразить наиболее уязвимых пожилых людей.
First results of the register of patients with osteoporosis included in the secondary fracture prevention services
Authors: Belova K. Yu. , Bublik E. V. , Gladkova E. N. , Gordjeladze H. G. , Dudinskaya E. N. , Ladygina D. O. , Morozova M. S. , Polyakova Yu. V. , Sivordova L. E. , Tanaev V. G. , Lesnyak O. M. 
Published: August 2021

Background. To reduce the number of osteoporotic fractures in the world in recent years, — Fracture Liaison Service has been created. Since 2019, the development of a register of patients included in the Secondary Fracture Prevention named «Prometheus» has begun in Russia.Materials and methods. An information system for storing, searching and processing information has been created, and a registration card has been developed. Six FLS participate in the register management. As of 10.03.2021, data on 387 patients were introduced in the register.Results. Among the included patients, 46.25% received a fracture of the proximal femur, 20.41% — of the vertebral bodies and 16.80% of the proximal humerus, the rest had fractures of other localizations. The risk of fractures was assessed in all patients. A high risk of major osteoporotic fractures according to FRAX was determined in 160 (43.24%) people. Two-energy X-ray absorptiometry (DXA) was performed in 152 (39.28%) patients, and osteoporosis was detected in 103 (67.76%), osteopenia — in 42 (27.63%) patients. The risk of falls was assessed in 100% of the included patients, and the risk of falls was determined to be high in 343 (88.63%) patients. Evaluation of various laboratory parameters to find the causes of secondary osteoporosis was performed in most patients. After consultation with the FLS doctor, anti-osteoporotic drugs were prescribed to 241 (64.27%) people. Among the rest, 70 (52.24%) patients had contra-indications and 31 (23.13%) people needed further examination.Conclusions. Thus, the use of the register allows you to evaluate all the main sections of the organization of assistance within the FLS and compare them with international standards to identify «gaps» and improve the work of the service.
The Epidemiology of Cognitive impairment in elderly patients with type 2 diabetes mellitus: prevalence and related clinical factors
Authors: Balashova A. V. , Glinkina I. V. , Fadeev V. V. 
Published: August 2021

Цель: оценить распространенность когнитивных нарушений (КН) у пожилых пациентов с сахарным диабетом (СД) 2 типа.
Near-Sun Switchback Boundaries: Dissipation with Solar Distance
Authors: Rasca Anthony P. , Farrell William M. , MacDowall Robert J. , Bale Stuart D. , Kasper Justin C. 
Published: August 2021

Abstract
The most surprising result from the first solar encounters by the Parker Solar Probe (PSP) is the large amount of brief magnetic field reversals often referred to as switchbacks. Switchbacks have previously been observed further downstream in the solar wind by spacecraft such as Helios 2 at 62 R

s
from the Sun. However, these observations lack a distinct proton temperature increase detected inside switchbacks by PSP, implying that they are evolving over time to eventually reach a pressure balance at the switchback boundaries. We look at the evolution of switchback boundaries as a function of radial distance from the Sun, from closest approach at 35.7 R

s
during PSP’s first two encounters to beyond 80 R

s
. Using magnetic field and proton data from PSP’s FIELDS and SWEAP instruments, we perform a day-by-day superposed epoch analysis of the 25 switchbacks with the sharpest step-like boundaries. During both encounters we found the proton temperature spikes to gradually decline before vanishing completely around 55 R

s
. Magnetic reversals and velocity spikes also steadily drop in magnitude, but eventually flatten out instead of disappearing. Most interestingly, proton temperature change ΔT

p
across switchback boundaries is found to reach 2 × 105 in magnitude below 40 R

s
during PSP’s outbound trajectory, but is an order of magnitude less on the inbound trajectory, suggesting a possible common change in switchback characteristics near closest approach during both encounters.