bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of female preference for odor of distant over local males in a bat with female dispersal
Authors: Schneeberger Karin , Schulze Michael , Scheffler Ingo , Caspers Barbara A 
Published: January 2021

AbstractGeographic variation of sexually selected male traits is common in animals. Female choice also varies geographically and several studies found female preference for local males, which is assumed to lead to local adaptation and, therefore, increases fitness. As females are the nondispersing sex in most mammalian taxa, this preference for local males might be explained by the learning of male characteristics. Studies on the preference of females in female-dispersing species are lacking so far. To find out whether such females would also show preferences for local males, we conducted a study on greater sac-winged bats (Saccopteryx bilineata), a species where females disperse and males stay in their natal colony. Male greater sac-winged bats possess a wing pouch that is filled with odoriferous secretion and fanned toward females during courtship display. In a combination of chemical analysis and behavioral preference tests, we analyzed whether the composition of wing sac secretion varies between two geographically distinct populations (300 km), and whether females show a preference for local or distant male scent. Using gas chromatography, we found significant differences in the composition of the wing sac odors between the two geographically distinct populations. In addition, the behavioral preference experiments revealed that females of both populations preferred the scent of geographically distant males over local males. The wing sac odor might thus be used to guarantee optimal outbreeding when dispersing to a new colony. This is—to our knowledge—the first study on odor preference of females of a species with female-biased dispersal.
Modes of Relational Agency among Welfare-reliant Mothers
Authors: Sinai-Glazer Hagit , Brummans Boris H J M 
Published: January 2021

Abstract
How do welfare-reliant mothers enact their agency in relationships with social workers and social services? The present article addresses this question by investigating how twenty Israeli welfare-reliant mothers expressed different modes of human agency in in-depth interviews. Results show how research participants enact agency through (i) expressing anger, (ii) seeking help, (iii) resisting and (iv) engaging in non-action. By highlighting the multidimensional and situational nature of agency, this article offers a new relational lens for conceptualising and empirically studying human agency in social work.
Cognitive and Neural Correlates of Loneliness and Wisdom during Emotional Bias
Authors: Grennan Gillian , Balasubramani Pragathi Priyadharsini , Alim Fahad , Zafar-Khan Mariam , Lee Ellen E , Jeste Dilip V , Mishra Jyoti 
Published: January 2021

Abstract
Loneliness and wisdom have opposing impacts on health and well-being, yet their neuro-cognitive bases have never been simultaneously investigated. In this study of 147 healthy human subjects sampled across the adult lifespan, we simultaneously studied the cognitive and neural correlates of loneliness and wisdom in the context of an emotion bias task. Aligned with the social threat framework of loneliness, we found that loneliness was associated with reduced speed of processing when angry emotional stimuli were presented to bias cognition. In contrast, we found that wisdom was associated with greater speed of processing when happy emotions biased cognition. Source models of electroencephalographic data showed that loneliness was specifically associated with enhanced angry stimulus-driven theta activity in the left transverse temporal region of interest, which is located in the area of the temporoparietal junction (TPJ), while wisdom was specifically related to increased TPJ theta activity during happy stimulus processing. Additionally, enhanced attentiveness to threatening stimuli for lonelier individuals was observed as greater beta activity in left superior parietal cortex, while wisdom significantly related to enhanced happy stimulus-evoked alpha activity in the left insula. Our results demonstrate emotion-context driven modulations in cognitive neural circuits by loneliness versus wisdom.
Controlling the Flow of Distracting Information in Working Memory
Authors: Hakim Nicole , Feldmann-Wüstefeld Tobias , Awh Edward , Vogel Edward K 
Published: January 2021

Abstract
Visual working memory (WM) must maintain relevant information, despite the constant influx of both relevant and irrelevant information. Attentional control mechanisms help determine which of this new information gets access to our capacity-limited WM system. Previous work has treated attentional control as a monolithic process—either distractors capture attention or they are suppressed. Here, we provide evidence that attentional capture may instead be broken down into at least two distinct subcomponent processes: (1) Spatial capture, which refers to when spatial attention shifts towards the location of irrelevant stimuli and (2) item-based capture, which refers to when item-based WM representations of irrelevant stimuli are formed. To dissociate these two subcomponent processes of attentional capture, we utilized a series of electroencephalography components that track WM maintenance (contralateral delay activity), suppression (distractor positivity), item individuation (N2pc), and spatial attention (lateralized alpha power). We show that new, relevant information (i.e., a task-relevant distractor) triggers both spatial and item-based capture. Irrelevant distractors, however, only trigger spatial capture from which ongoing WM representations can recover more easily. This fractionation of attentional capture into distinct subcomponent processes provides a refined framework for understanding how distracting stimuli affect attention and WM.
Layering and Displacement in Development Finance: The Asian Infrastructure Investment Bank and the Belt and Road Initiative
Authors: Skålnes Lars S. 
Published: January 2021

Abstract
This article explains why the Belt and Road Initiative (BRI) and the Asian Infrastructure Investment Bank (AIIB) are likely to have differential effects on the rules governing development finance. I draw on principal-agent models in arguing that in these two institutions, the delegation problem facing the Chinese government is different and therefore associated with different types of institutional change. The fragmented-authoritarian nature of the Chinese state profoundly affects delegation in the BRI. In the AIIB, in contrast, the delegation is to an international organization and hence not materially affected by the fragmented authoritarian nature of the Chinese state. Drawing on historical-institutionalist approaches to gradual institutional change, the article argues that the AIIB is likely to lead to institutional layering, the BRI to institutional displacement in development financing.
“Just a Couple of Queer Fish”: The Queer Possibilities of Rita Mae Brown’s Rubyfruit Jungle
Authors: Lorig Josette 
Published: January 2021

Abstract
Rita Mae Brown’s Rubyfruit Jungle (1973) is a foundational work of lesbian literature and has been characterized as a queer text. This essay begins with resistance to reading the novel as a wholly celebratory queer text because of how it positions a form of essentialized lesbianism against queer sexualities that are coded as deviant and abnormal. Nonetheless, Rubyfruit Jungle brims with queer narratives, queer scenes, and queer characters. In the essay’s second half, I draw on Eve Kosofsky Sedgwick’s model of reparative reading to engage with potential queer readings the novel affords. I show how readers can recuperate the queer sexualities the novel documents in ways that the novel – with its specific historical and political positionality – did not or could not account for.
Dysregulation of Metabolic Pathways in Circulating Natural Killer Cells Isolated from Inflammatory Bowel Disease Patients
Authors: Zaiatz Bittencourt Vanessa , Jones Fiona , Tosetto Miriam , Doherty Glen A , Ryan Elizabeth J 
Published: January 2021

AbstractBackground and AimsInflammatory bowel diseases [IBD], comprising Crohn’s disease [CD] and ulcerative colitis [UC], are chronic conditions characterized by severe dysregulation of innate and adaptive immunity resulting in the destruction of the intestinal mucosa. Natural killer [NK] cells play a pivotal role in the dynamic interaction between the innate and adaptive immune response. There is an increasing appreciation for the key role immunometabolism plays in the regulation of NK cell function, yet little remains known about the metabolic profile, cytokine secretion, and killing capacity of human NK cells during active IBD.MethodsPeripheral blood mononuclear cells were isolated from peripheral blood of patients with moderate to severely active IBD and healthy controls. NK cells were stained with a combination of cell surface receptors, intracellular cytokines, and proteins and analyzed by flow cytometry. For measurements of NK cell cytotoxicity, the calcein-AM release assay was performed. The metabolic profile was analyzed by an extracellular flux analyzer.ResultsNK cells from IBD patients produce large quantities of pro-inflammatory cytokines, IL-17A and TNF-α ex vivo, but have limited killing capability. Furthermore, patient NK cells have reduced mitochondrial mass and oxidative phosphorylation. mTORC1, an important cell and metabolic regulator, demonstrated limited activity in both freshly isolated cells and cytokine-stimulated cells.ConclusionsOur results demonstrate that circulating NK cells of IBD patients have an unbalanced metabolic profile, with faulty mitochondria and reduced capacity to kill. These aberrations in NK cell metabolism may contribute to defective killing and thus the secondary infections and increased risk of cancer observed in IBD patients.
Intergenerational mobility of sons and daughters: evidence from nineteenth-century West Flanders
Authors: Delabastita Vincent , Buyst Erik 
Published: January 2021

AbstractResearch on the intergenerational inheritance of occupational attainment has been restricted to sons for a long time. This is remarkable, given the ubiquity of historical settings where female labor force participation was high. This study of civil marriage certificates in nineteenth-century West Flanders investigates a comprehensive sample covering the economic activities not only of fathers and sons but also of mothers and daughters. We find that daughters were more mobile than sons. Daughters, however, enjoyed less growth in terms of intergenerational mobility against the background of a slowly industrializing economy.
Microbiome structure and functional potential in permafrost soils of the Western Canadian Arctic
Authors: Varsadiya Milan , Urich Tim , Hugelius Gustaf , Bárta Jiří 
Published: January 2021

ABSTRACT
Substantial amounts of topsoil organic matter (OM) in Arctic Cryosols have been translocated by the process of cryoturbation into deeper soil horizons (cryoOM), reducing its decomposition. Recent Arctic warming deepens the Cryosols´ active layer, making more topsoil and cryoOM carbon accessible for microbial transformation. To quantify bacteria, archaea and selected microbial groups (methanogens – mcrA gene and diazotrophs – nifH gene) and to investigate bacterial and archaeal diversity, we collected 83 soil samples from four different soil horizons of three distinct tundra types located in Qikiqtaruk (Hershel Island, Western Canada). In general, the abundance of bacteria and diazotrophs decreased from topsoil to permafrost, but not for cryoOM. No such difference was observed for archaea and methanogens. CryoOM was enriched with oligotrophic (slow-growing microorganism) taxa capable of recalcitrant OM degradation. We found distinct microbial patterns in each tundra type: topsoil from wet-polygonal tundra had the lowest abundance of bacteria and diazotrophs, but the highest abundance of methanogens. Wet-polygonal tundra, therefore, represented a hotspot for methanogenesis. Oligotrophic and copiotrophic (fast-growing microorganism) genera of methanogens and diazotrophs were distinctly distributed in topsoil and cryoOM, resulting in different rates of nitrogen flux into these horizons affecting OM vulnerability and potential CO2 and CH4 release.
Functional characterization of the putative FAD synthase from Mycoplasma hyopneumoniae
Authors: Cattani Amanda Malvessi , Pinheiro Camila Vieira , Schrank Irene Silveira , Siqueira Franciele Maboni 
Published: January 2021

ABSTRACT
In bacteria, the biosynthesis of the cofactor flavin adenine dinucleotide (FAD), important in many physiological responses, is catalyzed by the bifunctional enzyme FAD synthase (FADSyn) which converts riboflavin into FAD by both kinase and adenylylation activity. The in silico 3D structure of a putative FADSyn from Mycoplasma hyopneumoniae (MhpFADSyn), the etiological agent of enzootic pneumonia was already reported, nevertheless, the in vitro functional characterization was not yet demonstrated. Our phylogenetic analysis revealed that MhpFADSyn is close related to the bifunctional FADSyn from Corynebacterium ammoniagenes. However, only the domain related to adenylylation was assigned by InterPro database. The activity of MhpFADSyn was evaluated through in vitro enzymatic assays using cell extracts from IPTG-inducible heterologous expression of MhpFADSyn in Escherichia coli. The flavoproteins were analyzed by HPLC and results showed that IPTG-induced cell lysate resulted in the formation of twofold increased amounts of FAD if compared to non IPTG-induced cells. Consumption of riboflavin substrate was also threefold greater in IPTG-induced lysate compared to non IPTG-induced cell extract. Thus, the recombinant MhpFADSyn protein could be associated to FAD biosynthesis. These findings contribute to expand the range of potential drug targets in diseases control and unveil metabolic pathways that could be attribute to mycoplasmas.
MALELESS, A RECESSIVE AUTOSOMAL MUTANT OF DROSOPHILA MELANOGASTER THAT SPECIFICALLY KILLS MALE ZYGOTES
Authors: Fukunaga Akihiro , Tanaka Atsumi , Oishi Kugao 
Published: January 2021

ABSTRACT
A second chromosome male-specific lethal gene, maleless (mle), in D. melanogaster is described. It kills males but not females in homozygous condition, regardless of whether female parents are heterozygous or homozygous for mle. Many, if not most, homozygous males survive up to the third instar larval stage, but cannot pupate and die eventually as larvae. No interactions with sex-transforming genes, tra and dsx, were observed. It is proposed that mle interacts with a gene(s) on the X chromosome, which is not dosage compensated.
GENETIC DRIFT IN CLINES WHICH ARE MAINTAINED BY MIGRATION AND NATURAL SELECTION
Authors: Felsenstein Joseph 
Published: January 2021

ABSTRACT
Genetic drift will cause a migration-selection cline to wobble about its expected position. A rough linear approximation is developed, valid when local populations are large. This is used to calculate effects of genetic drift on clines in a stepping-stone model with abrupt and with gradual changes of selection coefficients at a single haploid locus. Among the quantities calculated are measures of slope, standardized variation of gene frequencies around their expected values, and correlation among neighboring populations with respect to deviations from the expected gene frequencies. These quantities appear to be primarily functions of Ns and Nm for a given pattern of selection. Computer simulation gives rough confirmation of these results. Standardized variances of gene frequencies and correlation of neighbors differ along the cline in the case of smooth changes in selection. In no case is pathological behavior of gene frequency deviations found near the boundaries of selective regions. Local behavior of gene frequencies of nearby colonies is approximately predicted by a simple adaptation of the stepping-stone theory of Kimura and Weiss. Approximate measures of the lateral variation of the midpoint of a cline and the probability of non-monotonicity are also calculated and discussed.
A DELETION MAP OF cyc1 MUTANTS AND ITS CORRESPONDENCE TO MUTATIONALLY ALTERED ISO-1-CYTOCHROMES c OF YEAST
Authors: Sherman Fred , Jackson Mary , Liebman Susan W , Schweingruber Ann Marie , Stewart John W 
Published: January 2021

ABSTRACT
Mutants arising spontaneously from sporulated cultures of certain strains of yeast, Saccharomyces cerevisiae, contained deletions of the CYC1 gene which controls the primary structure of iso-1-cytochrome c. At least 60 different kinds of deletions were uncovered among the 104 deletions examined and these ranged in length from those encompassing only two adjacent point mutants to those encompassing at least the entire CYC1 gene. X-ray-induced recombination rates of crosses involving these deletions and cyc1 point mutants resulted in the assignment of 211 point mutants to 47 mutational sites and made it possible to unambiguously order 40 of these 47 sites. Except for one mutant, cyc1-15, there was a strict colinear relationship between the deletion map and the positions of 13 sites that were previously determined by amino acid alterations in iso-1-cytochromes c from intragenic revertants.
Association Between Gut Microbiome and Frailty in the Older Adult Population in Korea
Authors: Lim Mi Young , Hong Seungpyo , Kim Jung-Ha , Nam Young-Do 
Published: January 2021

Abstract
Frailty is a common geriatric syndrome associated with the risk of adverse health outcomes. Recently, 2 key pathophysiological characteristics of frailty, altered energy metabolism and dysregulated immunity, have been reported to be associated with gut microbiome dysbiosis, indicating that the gut microbiome plays a role in frailty. However, few studies have directly examined the relationship between the gut microbiome and frailty. Here, we investigated the association of frailty measures with the gut microbiome using 16S rRNA gene sequencing data obtained from the fecal samples of 176 Korean older adults. Overall frailty was scored using the Korean Frailty Index (FI). Grip strength and Geriatric Depression Scale (GDS) scores were used as physical and mental frailty measures, respectively. In contrast to age, metabolic, and inflammatory biomarkers, the frailty measures were associated with interindividual variations in microbial composition (false discovery rate [FDR] &lt; 0.2). Both FI and GDS scores were negatively associated with microbial diversity (FDR &lt; 0.2). Frailty measures showed distinct associations with specific microbial taxa and metabolic functions. Particularly, the Bacteroides enterotype was found only in subjects categorized in the frail group. Moreover, we observed that the abundance of beneficial taxa, such as Prevotella copri and Coprococcus eutactus, was reduced in frailer individuals, whereas that of detrimental taxa, such as Bacteroides fragilis and Clostridium hathewayi, was increased (FDR &lt; 0.2). Our findings suggest that the gut microbiome can be used an indicator of an increased risk of frailty or a target for improving health in frail older adults.
Effect of Protein Intake on Visceral Abdominal Fat and Metabolic Biomarkers in Older Men With Functional Limitations: Results From a Randomized Clinical Trial
Authors: Huang Grace , Pencina Karol , Li Zhuoying , Apovian Caroline M , Travison Thomas G , Storer Thomas W , Gagliano-Jucá Thiago , Basaria Shehzad , Bhasin Shalender 
Published: January 2021

Abstract

Background
It remains controversial whether high protein diets improve cardiometabolic profile. We investigated whether increasing protein intake to 1.3 g/kg/day in functionally limited older adults with usual protein intake ≤RDA (0.8 g/kg/day) improves visceral fat accumulation and serum cardiovascular risk markers more than the recommended daily allowance (RDA).

Methods
The Optimizing Protein Intake in Older Men Trial was a placebo-controlled, randomized trial in which 92 functionally limited men, ≥65 years, with usual protein intake ≤RDA were randomized for 6 months to: 0.8 g/kg/day protein plus placebo; 1.3 g/kg/day protein plus placebo; 0.8 g/kg/day protein plus testosterone enanthate 100 mg weekly; or 1.3 g/kg/day protein plus testosterone enanthate 100 mg weekly. In this substudy, metabolic and inflammatory serum markers were measured in 77 men, and visceral adipose tissue (VAT) was assessed using dual-energy x-ray absorptiometry in 56 men.

Results
Treatment groups were similar in their baseline characteristics. Randomization to 1.3 g/kg/day protein group was associated with greater reduction in VAT compared to 0.8 g/kg/day group (between-group difference: −17.3 cm2, 95% confidence interval [CI]: −29.7 to −4.8 cm2, p = .008), regardless of whether they received testosterone or placebo. Changes in fasting glucose, fasting insulin, HOMA-IR, leptin, adiponectin, IL-6, and hs-CRP did not differ between the 0.8 versus 1.3 g/kg/day protein groups regardless of testosterone use.

Conclusions
Protein intake &gt;RDA decreased VAT in functionally limited older men but did not improve cardiovascular disease risk markers.

Clinical Trials Registration Number
NCT01275365
Analysis of Global Oxidative Status Using Multimarker Scores Reveals a Specific Association Between Renal Dysfunction and Diuretic Therapy in Older Adults
Authors: Rodríguez-Sánchez Elena , Navarro-García José Alberto , Aceves-Ripoll Jennifer , González-Lafuente Laura , Corbacho-Alonso Nerea , Baldan-Martín Montserrat , Madruga Felipe , Alvarez-Llamas Gloria , Barderas María G , Ruilope Luis M , Ruiz-Hurtado Gema 
Published: January 2021

Abstract
Aging and chronic kidney disease (CKD) are important interrelated cardiovascular risk (CVR) factors linked to oxidative stress, but this relationship has not been well studied in older adults. We assessed the global oxidative status in an older population with normal to severely impaired renal function. We determined the oxidative status of 93 older adults (mean age 85 years) using multimarker scores. OxyScore was computed as index of systemic oxidative damage by analyzing carbonyl groups, oxidized low-density lipoprotein, 8-hydroxy-2′-deoxyguanosine, and xanthine oxidase activity. AntioxyScore was computed as index of antioxidant defense by analyzing catalase and superoxide dismutase (SOD) activity and total antioxidant capacity. OxyScore and AntioxyScore were higher in subjects with estimated glomerular filtration rate (eGFR) &lt;60 mL/min/1.73 m2 than in peers with eGFR &gt;60 mL/min/1.73 m2, with protein carbonyls, catalase, and SOD activity as major drivers. Older adults with a recent cardiovascular event had similar OxyScore and AntioxyScore as peers with eGFR &gt;60 mL/min/1.73 m2. Multivariate linear regression analysis revealed that both indices were associated with decreased eGFR independently of traditional CVR factors. Interestingly, AntioxyScore was also associated with diuretic treatment, and a more pronounced increase was seen in subjects receiving combination therapy. The associations of AntioxyScore with diuretic treatment and eGFR were mutually independent. In conclusion, eGFR is the major contributor to the imbalance in oxidative stress in this older population. Given the association between oxidative stress, CKD, and CVR, the inclusion of renal function parameters in CVR estimators for older populations, such as the SCORE-OP, might improve their modest performance.