bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory and Pharmaceutical Data Associated With Hospital Readmission in Persons With Diabetic Foot Ulcers
Authors: Myers Alyson K. , Dawkins Makeda , Baskaran Inthuja , Izard Stephanie , Zhang Meng , Bissoonauth Aditya A. , Kaplan Sally , Rao Amit , Elzanaty Mohammad , Oropallo Alisha 
Published: November 2021

Purpose: Diabetic foot ulcers (DFUs) are a leading cause of lower extremity amputations among persons with diabetes (PWD) and a common cause of hospitalizations. This study identified demographic characteristics, lab values, and comorbidities associated with 30-day and 90-day hospital readmission in persons with DFU. Methods: A retrospective chart review at our institution examined 397 patients with type 2 diabetes admitted with DFU between January 2014 and December 2018. Variables were analyzed using descriptive statistics, t-tests, and logistic regressions. Results: None of the studied demographic, laboratory (including Hemoglobin A1c) or comorbid diseases were associated with 30-day readmission in persons with DFU. Risk factors for 90-day readmission included discharge location to home with health care (OR: 2.62, 95% CI: 1.39, 4.95), anticoagulant use (OR: 2.36, 95% CI: 1.27, 4.39), and SQ insulin use (OR: 2.08, 95% CI: 1.20, 3.61). Conclusions: None of the variables examined were associated with 30-day readmission; however, potential predictors for 90-day readmission included anticoagulation or insulin use and discharge home with healthcare services. Future studies should devise interventions to improve transition of care in patients with DFU to further assess the role of medications and home health care as a potential predictor of 90-day hospital readmission.
Fascism and Dependency in Latin America in the Thinking of Theotônio dos Santos
Authors: Machado Bichir Maíra 
Published: November 2021

The analysis of Theotônio dos Santos, a central reference of the Marxist theory of dependency, of the counterrevolutionary political processes in Latin America in the 1960s and 1970s, reflecting what he observes as an advance of fascistization, proposes the concept of a dependent fascism to characterize some of the military governments that materialized in the region. His writings on the subject are part of a wide range of debates that took place in Latin America during the 1970s, which focused on the context of political radicalization between revolution and counterrevolution, a tug-of-war that led to a consolidation of military coups. These writings express his position on both the political crisis that took place in Latin American countries at that time and the transformations of the political regime and the state itself. Efforts to renew these debates are anchored in the expectation that they may shed light on recent Latin American history. A análise de Theotônio dos Santos, referência central da teoria Marxista da dependência, sobre os processos políticos contrarrevolucionários na América Latina nas décadas de 1960 e 1970, ao observar um avanço da fascistização, propõe o conceito de fascismo dependente para caracterizar alguns dos governos militares que se concretizaram na região. Seus escritos sobre o tema se inscrevem em um amplo campo de debates que tiveram lugar na América Latina durante a década de 1970, os quais se debruçavam sobre o contexto de radicalização política entre revolução e contrarrevolução, no qual a consolidação de golpes militares estava imersa, e expressam o posicionamento do autor em relação tanto à crise política que teve lugar nos países latino-americanos naquele então, quanto às transformações do próprio regime político e do Estado. O esforço de recuperar tal debate está ancorado na expectativa de que tais reflexões possam lançar luz sobre a história recente latino-americana.
Dependency 4.0: Theoretical Considerations and the Brazilian Case
Authors: Paulani Leda Maria 
Published: November 2021

The liberalization of markets for goods and assets that took place beginning in the 1980s, alongside a strengthening of the resulting transnationalization of capital, did not alter the basic hierarchical organization of the global capitalist system. This new dependency, here called “dependency 4.0,” is based on the rent seeking that marks the contemporary wealth accumulation process and ongoing technological progress. Brazil’s incorporation into the international division of labor is emblematic of this type of subordination. A liberalização dos mercados de bens e ativos que teve lugar a partir dos anos 1980 e o fortalecimento da transnacionalização do capital que resultou daí não alteraram o pressuposto fundamental da prevalência de uma organização hierárquica no sistema capitalista mundial. Um novo tipo de dependência a relacionar países centrais e periféricos, dependência 4.0, estaria assentada no rentismo que marca hoje o processo de acumulação e na natureza do progresso tecnológico em curso. O caso do Brasil—a história de sua inserção na divisão internacional do trabalho—é emblemática desse novo tipo de subordinação.
Group-based telerehabilitation intervention using Wii Fit to improve walking in older adults with lower limb amputation (WiiNWalk): A randomized control trial
Authors: Tao Gordon , Miller William C. , Eng Janice J. , Esfandiari Elham , Imam Bita , Lindstrom Heather , Payne Michael W. 
Published: November 2021

Objective Determine efficacy of the novel WiiNWalk intervention on walking-related outcomes in older adults with lower limb amputation. Design Multi-site, parallel, evaluator-masked randomized controlled trial. Setting Home-setting in three Canadian cities. Participants Community-dwelling lower limb prosthesis users over 50 years of age. Interventions The WiiNWalk group (n = 38) used modified Wii Fit activities for prosthetic rehabilitation. The attention control group (n = 33) used Big Brain Academy: Wii Degree, comprising of cognitive activities. Both groups completed a 4-week supervised phase with three 1-h sessions/week in groups of three overseen by a clinician via videoconferencing and a 4-week unstructured and unsupervised phase. Main Measures Primary outcome was walking capacity (2 min walk test); secondary outcomes were balance confidence (activities-specific balance confidence scale), dynamic balance (four-step square test), and lower limb functioning (short physical performance battery). Outcomes were compared across time points with repeated measures analysis of covariance, adjusting for baseline and age. Results Mean age was 65.0 (8.4) years, with 179.5 (223.5) months post-amputation and 80% transtibial amputation. No group difference in a 2 min walk test with an effect size: 1.53 95% CI [−3.17, 6.23] m. Activities balance confidence was greater in the WiiNWalk group by 5.53 [2.53, 8.52]%. No group difference in the four-step square test −0.16 [−1.25, 0.92] s, nor short physical performance battery 0.48 [−0.65, 1.61]. A post-hoc analysis showed the greatest difference in balance confidence immediately after an unsupervised phase. Conclusions The WiiNWalk intervention improved balance confidence, but not walking-related physical function in older adult lower limb prosthesis users. Future rehabilitation games should be specific to the amputation context. Clinical Trial Registration number, NCT 01942798.
Prediction of central compartment nodal metastases in papillary thyroid cancer using TI-RADS score, blood flow, and multifocality
Authors: Yang Jin-Ru , Song Yan , Chang Shu-Juan , Shi Li-Li 
Published: November 2021

Background The relationship between the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) and the risk of lymph node metastases in papillary thyroid cancer (PTC) could improve the detection rate of lymph node metastases in thyroid cancer and provide a scientific basis for clinical diagnosis. Purpose To evaluate the risk of lymph node metastases of PTC associated with the score from ACR TI-RADS adjusted for other correlative factors. Material and Methods A total of 560 patients with pathologically confirmed PTC were included in the study and classified into a metastases group and a non-metastases group. Clinical and pathological manifestations of the patients were collected. Results The median TI-RADS score was 13 (p25–p75 = 11–14) among the patients with lymph node metastases, higher than those without metastases 9 (8–10) ( P < 0.001). Multiple logistic regression indicated that TI-RADS score (odds ratio [OR] = 2.204), male sex (OR = 2.376), multifocality (OR = 4.170), and rich blood flow (OR = 3.656) were risk factors for lymph node metastases in patients with thyroid carcinoma. Some related factors such as TI-RADS score, age(<45years old), male, multifocality and rich blood flow were related to lymph node metastases in the central area of the neck which could provide therapeutic strategy for further treatment. Conclusion it is not just the TI-RADS score but also multifocality, blood flow, and sex that influence the prediction of the risk of PTC central lymph node metastases.
Is the Great Barrier Reef dead? Satire, death and environmental communication
Authors: Foxwell-Norton Kerrie , Konkes Claire 
Published: November 2021

An obituary for the Great Barrier Reef (the Reef) by travel and food writer Rowan Jacobsen (2016) commemorated its ‘lifetime accomplishments’ in Outside, the US outdoor recreational magazine. ‘News’ of the Reef's demise went viral and the economic and political furore that followed was immense. Tourism industries, especially reliant on international arrivals, were impacted as potential visitors accepted the Reef's passing as fact. Politicians scampered to reassure Australians and the globe that the Reef was indeed still alive and beautiful. In the Australian public sphere, climate science deniers, alongside those advocating for climate action, collided over the impacts of global warming to Reef health. Subsequent mass coral bleaching events in 2016, 2017 and 2020 sustained at the very least, the idea that the Reef was, or was soon to be, dead. Our paper follows the idea of a ‘dead Reef’ in the context of historical and recent debates about Reef protection. Using Google Trends, we identify Jacobsen's article as the source of increased Australian and global ideation of a ‘dead Reef’. As a site of local and global environmental communication – where human relations to nature are expressed and understood - the Reef holds extraordinary story telling power. At the current junction then, the way we communicate the Reef is critical to public understanding and political action on climate change. We conclude Jacobsen's article is an example of the problems of satirical communication, serving to amplify existing conflicts and undermine efforts to foster to climate action.
Rhinoplasty Pre-Surgery Models by Using Low-Dose Computed Tomography, Magnetic Resonance Imaging, and 3D Printing
Authors: Baldi Dario , Basso Luca , Nele Gisella , Federico Giovanni , Antonucci Giuseppe Walter , Salvatore Marco , Cavaliere Carlo 
Published: November 2021

Rhinoplasty and surgical reconstruction of cartilaginous structures still remain a great challenge today. This study aims to identify an imaging strategy in order to merge the information from CT scans and magnetic resonance imaging (MRI) acquisitions and build a 3D printed model true to the patient’s anatomy, for better surgical planning. Using MRI, information can be obtained about the cartilage structures of which the nose is composed. Ten rhinoplasty candidate patients underwent both a low-dose protocol CT scan and a specific MRI for characterization of nasal structures. Bone and soft tissue segmentations were performed in CT, while cartilage segmentations were extrapolated from MRI and validated by both an expert radiologist and surgeon. Subsequently, a 3D model was produced in materials and colors reproducing the density of the three main structures (bone, soft tissue, and cartilage), useful for pre-surgical evaluation. This study has highlighted that the optimization of a CT and MR dedicated protocol has allowed to reduce the CT radiation dose up to 60% compared to standard acquisitions with the same machine, and MR acquisition time of about 20%. Patient-tailored 3D models and pre-surgical planning have reduced the mean operative time by 20 minutes.
Healthy lifestyle behaviors and the periodicity of mammography screening in Brazilian women
Authors: Patrão Ana Luísa , de Almeida Maria da Conceição C. , Matos Sheila M Alvim , Menezes Greice , Gabrielli Ligia , Goes Emanuelle F , Aquino Estela ML 
Published: November 2021

Introduction: Certain behaviors have been associated with health promotion, including mammography screening, in women worldwide. Objective: The objective of this study was to determine whether there is an association between the periodicity of mammography screening and healthy lifestyle behaviors in Brazilian women employed at a public university in Bahia, Brazil. Methods: A total of 635 women of 50–69 years of age at the time of the interview, from the Brazilian Longitudinal Study of Adult Health cohort who were resident in Bahia, participated in the study. Data were collected using a multidimensional questionnaire that included questions on participants’ sociodemographic characteristics and health-related behaviors (smoking, alcohol consumption, leisure-time physical activity and diet) and another questionnaire that dealt with risk factors and breast cancer screening. Measures of association were calculated using simple and multivariate logistic regression. Results: The practice of physical activity, not smoking, moderate alcohol consumption and a healthy diet were the health behaviors most adopted by the women who had last had a mammogram ⩽2 years previously (which is in line with the interval recommended by the Brazilian Ministry of Health). A statistically significant association was found between a lapse of ⩾3 years since last undergoing mammography screening and excessive alcohol consumption, while a borderline association was found between the same screening interval and leisure-time physical inactivity. Conclusion: There was an association between lifestyle risk behaviors and a longer time interval between mammography screenings. The present results contribute to the debate on the use of mammography, lifestyle behaviors and health promotion among women.
Effects of Nurse and Care Worker-led Foot-Care Program on Older People’s Foot Conditions: Before and After Intervention Study
Authors: Fujii Kashiko , Stolt Minna , Komoda Takuyuki , Nishikawa Mariko 
Published: November 2021

Introduction An increasing number of older people with frailty in Japan use geriatric day care centers. Older people who have been certified as requiring long-term care attend centers during the day and receive nursing care help with bathing, excretion, meals, and functional training services. Many older people have foot problems with need foot care by nurses and care workers (NCWs) at geriatric day care centers. Objective This study explored the effects of NCWs’ foot-care programs on the foot conditions of older people attending daytime services. Methods A before-after intervention study was conducted at geriatric day care centers for older people, where the foot-care program was presented by NCWs for two months. The foot conditions of 23 clients (8 men, 15 women, mean age = 78.6 years, standard deviation = 9.2) were assessed before and after the program. Changes in foot condition and clients’ perceptions after the study were analyzed through descriptive statistics, McNemar, and paired t-tests. Results Although dramatic changes in foot conditions were not observed, some conditions were improved or maintained. Changes were observed in mean dry skin scores ( p < .01; right foot: 1.6→1.1, left foot: 1.6→1.1), skin lesions and long nails (skin lesions R: 0.2→0.1; long nail R: 1.4→1.0, L: 1.1→0.8), and edema (R: 43.5%→39.1%, L: 52.2%→47.8%). Further, clients started perceiving that foot health is important and discussed their feet with staff more often. Conclusion The NCWs’ foot-care program was effective in maintaining and improving foot health in older people and positively affected their perception of foot care.
Relative model selection of evolutionary substitution models can be sensitive to multiple sequence alignment uncertainty
Authors: Spielman Stephanie J. , Miraglia Molly L. 
Published: November 2021

Abstract
Background
Multiple sequence alignments (MSAs) represent the fundamental unit of data inputted to most comparative sequence analyses. In phylogenetic analyses in particular, errors in MSA construction have the potential to induce further errors in downstream analyses such as phylogenetic reconstruction itself, ancestral state reconstruction, and divergence time estimation. In addition to providing phylogenetic methods with an MSA to analyze, researchers must also specify a suitable evolutionary model for the given analysis. Most commonly, researchers apply relative model selection to select a model from candidate set and then provide both the MSA and the selected model as input to subsequent analyses. While the influence of MSA errors has been explored for most stages of phylogenetics pipelines, the potential effects of MSA uncertainty on the relative model selection procedure itself have not been explored.

Results
We assessed the consistency of relative model selection when presented with multiple perturbed versions of a given MSA. We find that while relative model selection is mostly robust to MSA uncertainty, in a substantial proportion of circumstances, relative model selection identifies distinct best-fitting models from different MSAs created from the same set of sequences. We find that this issue is more pervasive for nucleotide data compared to amino-acid data. However, we also find that it is challenging to predict whether relative model selection will be robust or sensitive to uncertainty in a given MSA.

Conclusions
We find that that MSA uncertainty can affect virtually all steps of phylogenetic analysis pipelines to a greater extent than has previously been recognized, including relative model selection.
ScLRTC: imputation for single-cell RNA-seq data via low-rank tensor completion
Authors: Pan Xiutao , Li Zhong , Qin Shengwei , Yu Minzhe , Hu Hang 
Published: November 2021

Abstract
Background
With single-cell RNA sequencing (scRNA-seq) methods, gene expression patterns at the single-cell resolution can be revealed. But as impacted by current technical defects, dropout events in scRNA-seq lead to missing data and noise in the gene-cell expression matrix and adversely affect downstream analyses. Accordingly, the true gene expression level should be recovered before the downstream analysis is carried out.

Results
In this paper, a novel low-rank tensor completion-based method, termed as scLRTC, is proposed to impute the dropout entries of a given scRNA-seq expression. It initially exploits the similarity of single cells to build a third-order low-rank tensor and employs the tensor decomposition to denoise the data. Subsequently, it reconstructs the cell expression by adopting the low-rank tensor completion algorithm, which can restore the gene-to-gene and cell-to-cell correlations. ScLRTC is compared with other state-of-the-art methods on simulated datasets and real scRNA-seq datasets with different data sizes. Specific to simulated datasets, scLRTC outperforms other methods in imputing the dropouts closest to the original expression values, which is assessed by both the sum of squared error (SSE) and Pearson correlation coefficient (PCC). In terms of real datasets, scLRTC achieves the most accurate cell classification results in spite of the choice of different clustering methods (e.g., SC3 or t-SNE followed by K-means), which is evaluated by using adjusted rand index (ARI) and normalized mutual information (NMI). Lastly, scLRTC is demonstrated to be also effective in cell visualization and in inferring cell lineage trajectories.

Conclusions
a novel low-rank tensor completion-based method scLRTC gave imputation results better than the state-of-the-art tools. Source code of scLRTC can be accessed at https://github.com/jianghuaijie/scLRTC.
A new brood-pollination mutualism between Stellera chamaejasme and flower thrips Frankliniella intonsa
Authors: Zhang Bo , Sun Shu-Fan , Luo Wang-Long , Li Jia-Xin , Fang Qiang-En , Zhang De-Gang , Hu Gui-Xin 
Published: November 2021

Abstract
Background
Brood pollination mutualism is a special type of plant-pollinator interaction in which adult insects pollinate plants, and the plants provide breeding sites for the insects as a reward. To manifest such a mutualism between Stellera chamaejasme and flower thrips of Frankliniella intonsa, the study tested the mutualistic association of the thrips life cycle with the plant flowering phenology and determined the pollination effectiveness of adult thrips and their relative contribution to the host’s fitness by experimental pollinator manipulation.

Results
The adult thrips of F. intonsa, along with some long-tongue Lepidoptera, could serve as efficient pollinators of the host S. chamaejasme. The thrips preferentially foraged half-flowering inflorescences of the plants and oviposited in floral tubes. The floral longevity was 11.8 ± 0.55 (mean ± se) days, which might precisely accommodate the thrips life cycle from spawning to prepupation. The exclusion of adult thrips from foraging flowers led to a significant decrease in the fitness (i.e., seed set) of host plants, with a corresponding reduction in thrips fecundity (i.e., larva no.) in the flowers.

Conclusions
The thrips of F. intonsa and the host S. chamaejasme mutualistically interact to contribute to each other’s fitness such that the thrips pollinate host plants and, as a reward, the plants provide the insects with brooding sites and food, indicating the coevolution of the thrips life cycle and the reproductive traits (e.g., floral longevity and morphology) of S. chamaejasme.
Low cut-off value of serum (1,3)-beta-d-glucan for the diagnosis of Pneumocystis pneumonia in non-HIV patients: a retrospective cohort study
Authors: Taniguchi Jumpei , Nakashima Kei , Matsui Hiroki , Watari Tomohisa , Otsuki Ayumu , Ito Hiroyuki , Otsuka Yoshihito 
Published: November 2021

Abstract
Background
Non-human immunodeficiency virus (HIV) Pneumocystis pneumonia (PCP) is a fulminant disease with an increasing incidence. The serum beta-d-glucan (BDG) assay is used as an adjunct to the diagnosis of PCP; however, the cut-off value for this assay is not well-defined, especially in the non-HIV PCP population. Therefore, we aimed to identify the assay cut-off value for this population.

Methods
In this retrospective observational study, we reviewed the medical records of all patients (≥ 18 years old) with clinical suspicion of PCP who underwent evaluation of respiratory tract specimens between December 2008 and June 2014 at Kameda Medical Center. We created a receiver operating characteristic curve and calculated the area under the curve to determine the cut-off value for evaluating the inspection accuracy of the BDG assay.

Results
A total of 173 patients were included in the study. Fifty patients showed positive results in specimen staining, loop-mediated isothermal amplification assay, and polymerase chain reaction test, while 123 patients showed negative results. The receiver operating characteristic analyses suggested that the BDG cut-off level was 8.5 pg/mL, with a sensitivity and specificity of 76% and 76%, respectively.

Conclusions
The Wako-BDG cut-off value for the diagnosis of non-HIV PCP is 8.5 pg/mL, which is lower than the classical cut-off value from previous studies. Clinicians should potentially consider this lower BDG cut-off value in the diagnosis and management of patients with non-HIV PCP.
Trial registration: The participants were retrospectively registered.