bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with obstructive sleep apnea in Germany
Authors: Winter Yaroslav , Mayer Geert , Benes Heike , Burghaus Lothar , Floam Samantha , Parks Gregory S. , Kallweit Ulf 
Published: February 2025

Abstract

Purpose
Solriamfetol is approved for use in the European Union to treat excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA). SURWEY characterized real-world evidence regarding physician initiation and titration strategies and patient experiences with solriamfetol. We report SURWEY data for patients with OSA and EDS in Germany (N = 83).

Methods
SURWEY was a retrospective chart review conducted among physicians in Germany. Eligible patients were age ≥ 18 years who reached a stable solriamfetol dose and completed ≥ 6 weeks of treatment. Patients were grouped by solriamfetol initiation strategy: changeover, add-on, new-to-therapy.

Results
Patients’ mean (SD) age was 49 (14) years. New-to-therapy was the most common initiation strategy. Solriamfetol was initiated at 37.5 mg/day in most patients (n = 57, 69%) and titrated in 53 patients (64%); 30 (57%) completed titration within 2 weeks. In a post-hoc analysis, mean (SD) Epworth Sleepiness Scale (ESS) score was 16.0 (3.2) at baseline and decreased by 5.4 (3.6) at final follow-up (~ 16 weeks; p <.001). Improvement in patient- and physician-rated EDS was reported by ~ 90% of patients. Most patients (55%) reported effects of solriamfetol lasting ≥ 8 h; 91% of patients reported no change in nighttime sleep quality. The most frequent adverse events were headache (8%), decreased appetite (7%), and insomnia (6%).

Conclusion
Most patients in this study were new to therapy. Solriamfetol was typically initiated at 37.5 mg/day; titration was common. ESS scores improved with solriamfetol treatment, and most patients self-reported improvement in EDS symptoms. Common adverse events were consistent with those reported in previous clinical trials.
Suicide Risk Among Cannabis, Heroin and Cocaine Users
Authors: Sosa Miguel Zacarías Pérez , de-la-Vega-Sánchez Diego , Sanz – Gómez Sergio , Melvin Glenn , Sánchez – Gómez Ana , Guija Julio A. , Oquendo Maria A. , Giner Lucas 
Published: February 2025

Abstract
Individuals who use substances such as cocaine, cannabis, heroin, alcohol and nicotine are at increased risk for suicidal behavior. Our objective is to examine the relationship between substance use and suicide. An observational psychological autopsy study design was used to compare substance use in individuals who died by suicide and individuals who died by other manners. Subjects were recruited at the Medical Forensic Institute of Seville between 2006 and 2018. The total sample was 593 decedents including those who had died by suicide (n = 412) and those who died suddenly from non-suicidal causes (n = 181). We determined the association between substance (cannabis, heroin, cocaine, alcohol and nicotine) use and suicide. We also analyzed the behavioral association between the use of any one of these substances (cannabis, heroin, cocaine, alcohol, and nicotine), as well as the use of more than one substance at a time and manner of death (suicide vs not suicide). We established three categories of substance use: never-used, lifetime users (prior use but not in the past month), and past month users (use within the last month). This study found that decedents who died by suicide were more likely to have substance use compared with those who died by other means. Use of cocaine, cannabis, or heroin within the last month prior to death was associated with increased risk of suicide (X2 = 13.050; df = p = 0.001). Of the substances examined, the strongest association was between past month cocaine use and suicide after adjusting for Axis I and Axis II disorders. Our study supports the relationship between the use of illicit substances and suicide. The use of substances, independent of the type, was associated with a greater risk of suicide. Cocaine use had the strongest association with suicide.
Spatial-demographic analysis model for brain metastases distribution
Authors: Zhang Lin , Che Tongtong , Xin Bowen , Li Shuyu , Gong Guanzhong , Wang Xiuying 
Published: February 2025

Abstract

Purpose
The distribution analysis of the morphologic characteristics and spatial relations among brain metastases (BMs) to guide screening and early diagnosis.

Material and Methods
This retrospective study analysed 4314 BMs across 30 brain regions from MRIs of 304 patients. This paper proposed a unified analysis model based on persistent homology (PH) and graph modelling to provide a comprehensive portrait of BMs distribution. Spatial relationships are quantified through dynamic multiple-scale graphs constructed with Rips filtration. The multi-scale centrality importance and clustering coefficients are extracted to decode BMs spatial relations. Morphologic BMs characteristics are further analysed by varying radius and volume values that are considered as clinically influential factors. Finally, two-tailed proportional hypothesis testing is used for BM statistical distribution analysis.

Results
For spatial analysis, results have shown a statistical increase in the proportions of high-level centrality BMs at the left cerebellum (p<0.01). BMs rapidly form graphs with high clustering rather than those with high centrality. For demographic analysis, the cerebellum and frontal are the top high-frequency areas of BMs with 0-4 and 5-10 radii. Statistical increases in the proportions of BMs at cerebellum (p<0.01).

Conclusion
Results indicate that distributions of both BMs spatial relations and demographics are statistically non-random. This research offers novel insights into the BMs distribution analysis, providing physicians with the BMs demographic to guide screening and early diagnosis.
Prä- und perimigratorische Stressoren und Ressourcen ukrainischer Frauen in Deutschland – eine qualitative Betrachtung
Authors: Buchcik J. , Metzner F. , Kaltenbach S. , Kovach V. , Adedeji A. 
Published: February 2025

Zusammenfassung

Ziel der Studie
Frauen leiden seit der humanitären Krise in der Ukraine im Besonderem unter psychischen Belastungen. Es gibt nur eingeschränkte Studien, die Einblicke in die psychische Gesundheit, das Stressempfinden und möglichen Ressourcen ukrainischer Frauen in Deutschland geben, da diese die Komplexität von Belastungs- und Bewältigungserleben nicht subjektiv erfassen oder geschlechterübergreifend auswerten. Um diese Forschungslücke zu schließen, wird die folgende Forschungsfrage adressiert: Welche prä- und perimigratorischen Stressoren und Ressourcen nehmen geflüchtete Frauen aus der Ukraine subjektiv wahr?

Methodik
Es wurden drei Fokusgruppeninterviews durchgeführt. Die Gespräche erfolgten in Form von semistrukturierten Interviews anhand eines Interviewleitfadens, der Erfahrungen und Lebensumstände zu Beginn des Krieges, während der Flucht aus der Ukraine und der Ankunft in Deutschland umfasste. Die Analyse erfolgte unter Anwendung der qualitativen Inhaltsanalyse, bei der Kategorienbildung wurde ein deduktiv-induktiver Ansatz verfolgt.

Ergebnisse
Es konnten insgesamt n = 15 Ukrainerinnen zwischen 18 und 56 Jahren zur Teilnahme an den Gruppeninterviews gewonnen werden. Die Migrationsstressoren und -ressourcen, die sich als wesentlich für die psychische Gesundheit vor und während ihrer Flucht zeigen, können in drei Hauptkategorien (individuelle, psychosoziale und strukturelle) unterteilt werden. Das Erleben von Bedrohung und Verlusten, häufig vermittelt über soziale Medien, spielt in der Fluchtphase eine Rolle. Das emotionale Erleben ist geprägt durch den Umgang mit belastenden Gefühlen wie Angst, Schuld, Scham und Neid sowie Unsicherheiten in Bezug auf ein Leben im Ausland.

Schlussfolgerung
Interventionen sollten bereits vor und während der Flucht beispielsweise Selbstfürsorge, einen psychisch gesunden Umgang mit sozialen Medien, Strategien zur Emotionsregulation sowie einen funktionalen Umgang mit Gefühlen wie Schuld und Scham adressieren.
Insoluble dietary fiber and microparticle formation from olive pomace: effects on emulsification and interfacial behavior in Pickering emulsions
Authors: Aslan Türker Duygu , Işçimen Elif Meltem 
Published: February 2025

Abstract
In this study, we systematically produced particles and insoluble dietary fibers (IDFs) with varying particle sizes from olive pomace, a by-product of olive oil manufacturing, and conducted an extensive characterization of their physicochemical, technological, and structural properties. These materials were then utilized in the formulation of Pickering emulsions, facilitating an investigation into the correlation between particle characteristics and emulsion stability. Emulsions formulated with IDFs exhibited ζ potential values exceeding − 20 mV and displayed minimal fluctuations in particle size. The lowest interfacial tension, indicative of maximal adsorption at the oil–water interface, was observed in olive pomace fiber (OPF) (37.01 mN/m at 10 s). With time, the interfacial tension of all emulsions decreased, suggesting continuous particle adsorption at the oil–water interface. Additionally, Pickering emulsions stabilized by IDFs demonstrated significantly higher θ values, highlighting their superior emulsification efficacy in enhancing Pickering emulsion stability. This investigation lays the groundwork for the development of stable Pickering emulsions utilizing olive pomace, a by-product of olive oil production, and for the comprehensive utilization of olive oil waste. Overall, these findings suggest that the incorporation of olive pomace IDFs holds substantial promise in enhancing the stability of Pickering emulsions.
Structural equation modeling to explore putative causal factors for chronic fatigue in childhood cancer survivors: a DCCSS LATER study
Authors: Penson Adriaan , Bucur Ioan Gabriel , Walraven Iris , Grootenhuis Martha A. , Maurice-Stam Heleen , van der Heiden-van der Loo Margriet , van der Pal Helena J. H. , de Vries Andrica C. H. , Bresters Dorine , van den Heuvel-Eibrink Marry M. , Neggers Sebastian , Versluys Birgitta A. B. , Louwerens Marloes , Pluijm Saskia M. F. , Blijlevens Nicole M. A. , van Dulmen-den Broeder Eline , Kremer Leontien C. M. , Heskes Tom , Loonen Jacqueline , Knoop Hans ,   on behalf of the Dutch LATER study group
Published: February 2025

Abstract

Purpose
To explore putative causal relations for chronic fatigue (CF) in childhood cancer survivors (CCS) using structural equation modeling (SEM).

Methods
Interrelationships between factors that were previously associated with CF and their causal relation with CF were investigated using SEM and causal discovery methodology. A bootstrap method was used to ascertain how robust each finding was, presenting the percentage of times that each discovered edge was found in 1000 bootstrap samples as a measure of confidence (with > 50% needed to be confident in a found edge).

Results
1927 CCS (51.7% male) with a mean age of 35 years (SD 9) participated in the study (23.6% reported CF). Results indicated that sex had a putative causal effect on CF (bootstrap confidence 81%), while CF was causally linked to helplessness, physical activity, pain, BMI, and sleep problems (bootstrap confidence 82%, 78%, 78%, 51%, and 51%, respectively). The relation between CF and depression was found to be two-way (bootstrap confidence 68%), indicating a reciprocal relation or the presence of a latent confounder. The same applied to the relations between CF and anxiety, self-esteem, and social functioning, but this could not be confirmed with high confidence (bootstrap confidence < 50%).

Conclusion
This study provides insight into the complex etiology of CF and could give guidance in the development of appropriate prevention and/or intervention strategies for CF in CCS.

Implications for Cancer Survivors
Results show the consequences of having CF and could help to understand the impact it has on daily life.
Exploring the Interplay between Drought Resilience and Yield in Maize Hybrids for Drought-Prone Regions
Authors: Bal Senem Sabancı , Adak Alper , Erdal Şekip 
Published: February 2025

Abstract
This study explores the selection of maize inbreds and their subsequent hybridization, followed by the evaluation of the resulting hybrids across multi-environment trials under irrigated and non-irrigated conditions. Variance decomposition analysis revealed that environmental and trial-specific factors contributed significantly to yield variation, with 75.66% of the total variance under non-irrigated conditions attributed to trial management (Trial[Env]). Genotype accounted for 11.36%, and genotype-by-trial interactions explained 8.43%. Based on Drought Resilience Index (DRI) values, promising inbreds such as Ant-69 and Ant-24,702 were selected for hybrid development. Hybrid H3, developed from inbreds Ant-69 and Ant-24,702, exhibited strong performance across environments, consistently ranking within the top three for yield and stability. Its slow senescence, resulting in an extended grain-filling period, contributed significantly to its superior yield stability even under water-deficient conditions. Using BLUPs, hybrid performance was evaluated, with H3 demonstrating high yield stability across both irrigated and non-irrigated trials. The hybrids like C2 and H4 were highly responsive to favorable (irrigated) environments, H3 maintained greater stability across varying environments. The WAASBY index ranked H3, along with hybrid C1, as the top-performing genotypes, combining both high yield and stability. AMMI and GGE biplot analyses further confirmed H3’s broad adaptability across multiple environments. These findings emphasize the significance of selecting superior inbreds, such as Ant-69 and Ant-24,702, to create hybrids that are capable of performing well under diverse environmental conditions. This research highlights the essential role of inbred selection in developing high-performing hybrids like H3, which show both yield stability and drought resilience across varying environmental conditions. The inclusion of non-irrigated trials as non-favorable environments was crucial for identifying hybrids with stay-green traits, such as extended grain-filling periods, that contribute to improved yield stability under drought. These findings emphasize the importance of evaluating hybrids across contrasting environments to develop cultivars optimized for both productivity and stability in drought-prone regions.
Mindfulness Profiles and Substance Use Outcomes in University Students: The Role of Alcohol and Cannabis Use Motives
Authors: Folivi Folly , Bravo Adrian J. , Pearson Matthew R. 
Published: February 2025

Abstract

Objectives
The present study aimed to identify distinct profiles of mindfulness among a sample of university students in the USA who use alcohol and cannabis. Further, we examined whether these mindfulness profiles were indirectly associated with alcohol and cannabis-related outcomes via alcohol and cannabis use motives.

Method
Latent profile analysis (LPA) was used to determine the number of latent classes among 771 US university students (75.7% White, 66.8% female) who consumed alcohol and cannabis in the prior month. Additionally, parallel mediation analyses were conducted to determine whether mindfulness profiles were indirectly associated with alcohol- and cannabis-related outcomes via alcohol and cannabis use motives.

Results
LPA indicated a 4-class solution fit optimally. Further, the high mindfulness group was generally the most adaptive (lower scores) across alcohol and cannabis outcomes, whereas the judgmentally observing group was generally the most maladaptive (higher scores). Indirect effect analyses revealed that compared to the low mindfulness group, the high mindfulness group reported lower scores on alcohol- and cannabis-related outcomes via lower alcohol- and cannabis-related coping motives.

Conclusions
These findings can inform prevention and intervention efforts using mindfulness techniques and interventions among students who engage in problematic alcohol and cannabis use.

Preregistration
This study is not preregistered.
Eco-pilgrimages: Linking humans, heritage, and hydrology
Authors: Strang Veronica , Luetz Johannes M. 
Published: February 2025

Abstract
Over the last century, the health of aquatic ecosystems around the world has reached critical levels. In the UK, waterways are severely polluted, and yet many wells and springs are still venerated as ‘sacred’. This article presents ‘eco-pilgrimages’ as a sustainability strategy to connect key heritage sites through ecological corridors. This aims, simultaneously, to strengthen biodiversity; to enable immersive historical and ecological education; to contribute to human well-being; and to provide more effective flood amelioration in river catchment areas.
Gender in industrial mine work and organizations – recommended actions toward gender equality
Authors: Heimann Samuel , Johansson Kristina 
Published: February 2025

Abstract
Questions of how the mining industry can address gender imbalance and inequality are recurring and increasing across the sector. Neglecting how gender affects organizational processes, work environment and work, risks reproducing, rather than transforming the organizational culture and processes that uphold masculine culture and male domination in the industry. The aim of the article is to give research-based suggestions to the industry - companies and policy-makers - on how the results of gender perspectives in research on mining organizations can contribute to inclusive and innovative work environments, organizational cultures and processes in mining. Based on an extensive review of previous research on gender in mining, the study concludes that possible transformative change, through new technology and new forms of organization, may enable organizations to shift the gendered structure of mining. A shift toward automated mines and increase of industrial mining due to the demands of the green transition will lead to new types of jobs and new forms of organizing mining work. Within these changes lies a possibility to transform gendered structures in mining.
Insights into depression prediction, likelihood, and associations in children and adolescents: evidence from a 12-years study
Authors: Haque Umme Marzia , Kabir Enamul , Khanam Rasheda 
Published: February 2025

Abstract

Purpose
The severity of depression among young Australians cannot be overstated, as it continues to have a profound impact on their mental health and general wellbeing. This study used machine learning (ML) algorithms to analyse longitudinal data, identifying key features to predict depression, assess future risk, and explore age-specific behaviours that contribute to its progression over time. The results emphasize the significance of early detection to prevent unfavourable consequences and shed light on the alterations in depressive symptoms during various stages of development.

Methods
Three widely regarded ML techniques—random forest (RF), support vector machine (SVM), and logistic regression (LR)—are being applied and compared with a longitudinal data analysis. Additionally, the Apriori algorithm is being utilized to explore potential relationships between health, behaviour, and activity issues with depression among different age groups (10–17).

Results
The analysis results indicate that the RF model is performing exceptionally well in diagnosing depression, with a 94% accuracy rate and weighted precision of 95% for non-depressed and 88% for depressed cases. In addition, the LR model shows promising results, achieving an 89% accuracy rate and 91% weighted precision. Moreover, insights from the Apriori algorithm underscore the significance of early detection by examining potential associations between health, behaviour, and activity problems and depression across diverse age groups.

Conclusion
Combining early screening programs with the RF model and the Apriori algorithm is crucial for understanding depression and developing effective prevention strategies. Emphasizing Apriori's factors and regularly updating strategies with new information will enhance depression management and prevention.
Exploring perceptions of interreligious learning and teaching and the interplay with religious identity: a synthesis of a five- part evolving study
Authors: Foley Toni 
Published: February 2025

Abstract
This paper synthesises findings from five small studies seeking to explore the perceptions of individuals engaged in interreligious learning and teaching to uncover what might be possible for students in contemporary Catholic schools. The reality of Australian Catholic schools is that they are pluralising contexts reflective of the general Australian population profile. This brings to the fore that the clientele of many Catholic schools is religiously/culturally diverse. Engaging with diversity in a respectful and meaningful way has the potential to yield benefits for all (religious and non-religious) and to contribute to addressing the Australian educational goals for all. The paper, drawing on findings from five studies utilising a variety of methodologies, including autoethnography, hermeneutic (pedagogical) phenomenology and case study employing basic qualitative inquiry. It reveals the key contribution of educational leadership and approaches to Religious Education. The research contributes a fresh perspective to the ever-developing Religious Education agenda with some possibilities that might resonate with, and be viable in, other contexts looking to address evolving opportunities to invest in the future of young learners.
Synthesis of ZnO nanoparticles using a modified polymer complex method and evaluation of their biological effect on Capsicum annuum L
Authors: Durán-Fernández Santiago , Bermudez-Zambrano Oscar Dario , Rodríguez-Páez Jorge E. 
Published: February 2025

Abstract
In this work, zinc oxide nanoparticles (ZnO-NPs) were synthesized using a chemical route. The ZnO obtained was characterized using infrared and Raman spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results indicated that the synthesized ZnO had a unique crystal structure corresponding to the wurtzite type. The primary particles of the synthesized oxide had a size < 100 nm, a crystallite size of ~ 33.20 nm and spheroidal morphology. These primary particles formed agglomerates with an average size of ~ 460 nm. The bandgap values of the synthesized ZnO were between ~ 2.7 and 2.8 eV, with an Urbach energy of ~ 340 meV. Considering the potential use of synthesized ZnO-NPs and commercial ZnO (ZnO-MPs) in agriculture, seeds of C. annuum were exposed to treatments at concentrations of 0, 10, 20, 50, 100 and 200 mg L−1 of ZnO-NPs or ZnO-MPs to determine their biological effect. A relevant result was the decrease in the dry weight of the plumule, in the proportion indicated in parentheses, of the seedlings obtained from seeds exposed to ZnO-NPs, in concentrations of 10 mg L−1 (15%), 20 mg L−1 (17%) and 200 mg L−1 (13%), or treated with ZnO-MPs, in concentrations of 10 mg L−1 (19%) and 100 mg L−1 (13%). These treatments could cause toxicity in the seedling since the reduction in the recorded dry weight was equal to or greater than 10%, a percentage considered as a benchmark for the critical level of toxicity.