bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obra y público, tradición y generación: ¿cómo propiciar el encuentro?
Authors: Vaquero Cañestro Carmen , Gómez del Águila Luisa María 
Published: June 2021

El arte actual, fruto de un sistema que oscila entre la extrema individualización y la “pseudoglobalización”, ha renunciado al aura de prestigio que, durante siglos, le había acompañado, caracterizado e, incluso, definido. Mientras en épocas pasadas, el arte se mostraba como paradigma de lo sublime –tanto por la genialidad a la que se asociaba, como por la intencionada situación de la obra en un plano elitista–, desde hace décadas deja su pedestal invitando al público a adentrarse en la obra, completándola. Es evidente que la imagen consolidada por siglos de tradición, no responde a las demandas de sociedades complejas y extremadamente dinámicas. Sin embargo, los propios mediadores que deberían quebrarla, para propiciar el acercamiento, la perpetúan. La Educación en Artes Plásticas y Visuales tiene que asumir la responsabilidad de suscitar contextos en los que el encuentro sea posible.
La Didáctica del Flamenco y su multidisciplinariedad: el proyecto COFLA (Análisis Computacional de la Música Flamenca)
Authors: Gutiérrez Cordero Rosario , Perea Díaz Benjamín 
Published: June 2021

En este trabajo se expone un trabajo de investigación sobre el flamenco con una clara aproximación multidisciplinar, el proyecto COFLA. COFLA (Análisis Computacional de la Música Flamenca) (P09-TIC-4840) es un Proyecto de Excelencia subvencionado por la Junta de Andalucía (2010-2013). Dentro del área de Protección de la Herencia Cultural, el flamenco está señalado como de especial consideración en las bases reguladoras de las convocatorias de ayudas de investigación de la Junta de Andalucía. En este proyecto, se abordan varios temas concretos de investigación que surgen al estudiar la música flamenca desde disciplinas donde tradicionalmente no se han considerado, con un énfasis en el uso de métodos computacionales. En concreto, se estudian, desde diferentes perspectivas, las características de los diferentes estilos, variantes e intérpretes del flamenco. Debido a la propia naturaleza multidisciplinar de la investigación, del estudio de la música flamenca se desprenden temas de estudio que suponen avance en el conocimiento e investigación de áreas tan dispares como las matemáticas, la antropología, la ingeniería, la pedagogía y la musicología. Aquí hacemos énfasis en la vertiente educativa de COFLA, con el objetivo de utilizar el conocimiento adquirido desde las diferentes disciplinas en la docencia de la música flamenca.
Expression of the apelinergic system and its influence on functional properties of tumor cells
Authors: Knezevic Zoran , Wellbrock Jasmin , Fuchs Frauke , Vohwinkel Gabi , Matzat Antonia , Fiedler Walter 
Published: June 2021

mall peptide Apelin and its cognate receptor APJ, are known to play a role in tumor angiogenesis and overall cancer progession. Certain authors suggest that the Apelin receptor is also a factor in cancer immunotherapy. In this article, our goal was to study the effects of in vitro targeting of the Apelin/APJ system on the tumor cells functional properties. Protein surface and mRNA expression of Apelin and APJ had been largely examined in various tumor-derived cell lines. In contrast to the tumor tissue, the results of this study demonstrated that most tumor cell lines exhibited somewhat moderate expression of Apelin/APJ. Similar effects of APJ stimulation and inhibition had been observed in in vitro functional assays, which was due to their unusually low expression levels. Low APJ expression in cell lines has been overcome by stable APJ overexpression. In such conditions, stimulation of apelinergic system APJ-overexpressed cells affected cell functional properties in comparison to the wildtype cell lines, where overexpression of APJ receptor resulted in increased migration. On the other hand, no effect on cell proliferation was observed. Consequently, Apelin/APJ signaling in tumor-derived cell lines is not expected to play a direct and crucial role in in vitro cancer survival. Further investigation should focus on in vivo role of the apelinergic system, as demonstrated in the recently published studies, where apelinergic system is claimed to be a promising target for anti-cancer therapy.
Contemporary population genetics data for 23 Y-STR loci in the general Bosnian-Herzegovinian population
Authors: Babić Jordamović Naida , Kojović Tamara , Dogan Serkan , Bešić Larisa , Salihefendić Lana , Konjhodžić Rijad , Ćordić Sabahudin , Škaro Vedrana , Projić Petar , Hadžiavdić Vesna , Ašić Adna , Marjanović Damir 
Published: June 2021

Bosnia and Herzegovina is located in the South-Eastern Europe, characterized by numerous historical influences, massive migration processes and complex population structure. For that reason, the aim of this study is to provide an accurate and precise update of the population genetics data of allele frequencies on 23 Y-STR loci in Bosnia and Herzegovina using larger sample size. For this purpose, 480 adult male individuals from the general population have been genotyped over 23 Y-STR loci contained in the PowerPlex Y23 system. Population genetics parameters have been calculated, namely allele and haplotype frequencies, gene and haplotype diversity, as well as Rst and P values for the assessment of interpopulation differences. The obtained results are in close agreement with previously published data for Bosnian-Herzegovinian population, as well as for local subpopulations. This study offers significantly increased resolution and information content, with 454 unique haplotypes. Population comparison reveals no statistically significant differences between the study population and 12 European populations used for comparison, as visualized through an MDS plot and neighbour-joining phylogenetic tree. This study offers representative data for local Y chromosomes that can be used for forensic applications, paternity and kinship testing, as well as for genealogical studies.
Results of surgical treatment after Gamma Knife radiosurgery for cerebral arteriovenous malformations: patient series
Authors: Shimizu Atsushi , Yamaguchi Koji , Okada Yoshikazu , Funatsu Takayuki , Ishikawa Tatsuya , Hayashi Motohiro , Tamura Noriko , Horiba Ayako , Kawamata Takakazu 
Published: June 2021

BACKGROUND
Gamma Knife radiosurgery (GKRS) is a safe and effective treatment, but it has a risk of bleeding. Herein, the authors describe their experience with some patients who required surgical removal of cerebral arteriovenous malformations (AVMs) located mainly in eloquent areas of the brain after GKRS, and they consider the advantages of surgical removal after GKRS.

OBSERVATIONS
Twelve patients who had undergone surgical removal of AVMs after GKRS at Tokyo Women’s Medical University between April 2013 and July 2019 were selected for analysis. All participants underwent GKRS as first-line therapy for AVMs located in an eloquent region or if requested by the patient. Complete obliteration was achieved in 7 patients, and the size of the nidus decreased in 3 patients during the follow-up period. The Spetzler-Martin grade decreased in 11 patients. Three patients experienced symptomatic intracerebral hemorrhage before and after confirmation of complete obliteration of the nidus via GKRS, and 7 patients experienced some neurological deficits because of an encapsulated expanding hematoma. All patients underwent resection of the nidus without complications. The preoperative neurological deficits improved in 6 patients and remained unchanged in 6 patients.

LESSONS
This report indicates that performing GKRS before surgery may be useful for future multimodal therapy.
Favorable outcome of repeat mechanical thrombectomy in a geriatric patient: illustrative case
Authors: Alsarah Ali A. , Hussein Omar M. , Carlson Andrew P. 
Published: June 2021

BACKGROUND
The authors presented their experience with a case of repeat thrombectomy in a 93-year-old patient who showed a favorable outcome after recurrent large vessel occlusion treated with emergency mechanical thrombectomy.

OBSERVATIONS
Mechanical thrombectomy has been proven to be effective in treating large vessel occlusion types of ischemic stroke. Most of the patient populations involved in the thrombectomy-related studies were younger than 80 years. In addition, recurrent mechanical thrombectomy is not a common procedure in clinical practice. This unusual case demonstrated the potential to achieve a favorable outcome with thrombectomy even in a patient older than 85 years with recurrent large vessel occlusion.

LESSONS
There can be a favorable neurological outcome after one or repeat thrombectomies for geriatric patients older than 90 years, and age should not be a deterrent to treatment.
Analisis Neraca Keseimbangan Air Baku Layanan PDAM Amuntai
Authors: Al-Qadar Al-Qadar - , Fakhrurrazi Fakhrurrazi 
Published: June 2021

Abstrak
PDAM BNA Amuntai adalah unit penyedian air bersih di Kabupaten Hulu Sungai Utara yang melayani penyediaan air bersih untuk keperluan masyarakat tiga kecamatan yaitu Amuntai Utara, Selatan dan Tengah. Laju angka pertumbuhan di tiga kecamatan ini membuat kebutuhan air bersih semakin bertambah setiap tahunnya. Pengadaan air bersih untuk masyarakat bertujuan agar lapisan masyarakat menjalani pola hidup sehat.Untuk mengetahui jumlah kebutuhan air bersih pada tahun tertentu, menggunakan analisis proyeksi penduduk dengan standar kebutuhan air bersih berdasarkan panduan Kementrian PU. Menghitung ketersedian air disungai Balangan (debit andalan) menggunakan analisis data klimatologi dan data bangkitan hujan menggunakan metode mock. Hasil analisis jumlah penduduk di tiga kecamatan layanan PDAM BNA Amuntai pada tahun 2049 berdasarkan hasil proyeksi penduduk sebanyak 154.972,2 jiwa. Dengan layanan 90% kebutuhan masyarakat terhadap air bersih layanan PDAM BNA Amuntai pada tahun 2049 sebanyak 771.843,38 m³/bulan. Hasil analisis debit andalan ketersedian air baku sebanyak 12.933.464,72 m³/bulan. Sehingga persentase kebutuhan air bersih sebesar 5,97%. terhadap ketersedian air baku di sungai.
Abstract
PDAM BNA Amuntai is a clean water supply unit in the North Hulu Sungai Regency that serves clean water for the needs of the community of three sub-districts, namely North, South and Central Amuntai. The rate of growth in these three sub-districts makes the need for clean water growing every year. The provision of clean water aims to ensure that the layers of society live a healthy lifestyle. Analysis of population projections with clean water requirements based on the Ministry of Public Works guidelines to calculate clean water needs. Calculating the availability of water in the Balangan river (mainstay discharge) using climatological data analysis and rainfall generation data using the mock method. The results of the analysis of the population in the three sub-districts of PDAM BNA Amuntai service in 2049 based on the projection of the population of 154,972.2 people. With 90% service, the community's need for clean water services at PDAM BNA Amuntai in 2049 is 771,843.38 m³/month. The results of the main discharge analysis of the availability of raw water were 12,933,464.72 m³/month. So the percentage of clean water needs is 5.97%. towards the availability of raw water in the river
ANALISIS PERAMALAN HARGA EMAS DI INDONESIA PADA MASA PANDEMI COVID-19 UNTUK INVESTASI
Authors: Dewi Dyah Makutaning , Nafi' Muhammad Zaky , Nasrudin Nasrudin 
Published: June 2021

Pandemi Coronavirus Disease-2019 (Covid-19) merupakan kejadian yang tidak biasa. Adanya Covid-19 membuat masyarakat ragu dalam melakukan investasi. Hal ini dikarenakan kondisi perekonomian dunia tidak sedang dalam kondisi baik. Investasi emas merupakan salah satu investasi yang cukup aman di masa pandemi Covid-19. Logam mulia tersebut banyak dipilih karena mayoritas masyarakat telah familiar terhadap emas serta mudah dijangkau. Selain itu, dikarenakan harga emas cenderung stabil dan jarang mengalami penurunan harga, justru saat ini mengalami peningkatan harga dalam waktu yang singkat. Salah satu cara untuk mengetahui gambaran harga emas di Indonesia agar masyarakat tertarik melakukan investasi logam mulia tersebut adalah melakukan peramalan dengan menggunakan metode ARIMA Box-Jenkins. Tujuan penelitian ini adalah memperoleh prediksi harga emas di Indonesia selama 30 hari ke depan. Hasil analisis menunjukkan bahwa didapatkan model ARIMA (1,1,1) sehingga dapat disimpulkan bahwa prediksi harga emas 30 hari ke depan terus mengalami peningkatan dengan persentase kesalahan training data sebesar 1,005 persen serta validasi ramalan dari testing data sebesar 3,93 persen.
Verso una nuova rilevanza penale dello sfruttamento di manodopera. Simbolismo ed effettività della risposta punitiva
Authors: Fiore Stefano 
Published: June 2021

La recrudescenza dei fenomeni di "caporalato" nel nostro paese, certamente collegata ai flussi di migranti clandestini che offrono un ricco serbatoio dal quale attingere nuove e particolarmente vulnerabili vittime dello sfruttamento, non ha trovato nella legislazione penale vigente adeguati strumenti di contrasto. La rilevanza penale dei fatti riconducibili al c.d. caporalato, quando non viene collocata in fattispecie "comuni" (come la violenza privata o l'estorsione), si distribuisce tra le poco efficaci ipotesi contravvenzionali previste all'art. 18 del d.lgs. 10 settembre 2003, n. 276 ed il delitto di riduzione o mantenimento in schiavitù, normalmente sovradimensionato sia sul piano strutturale, che su quello del correlativo impegno probatorio. L'elevato valore dei beni in gioco (libertà, autodeterminazione, dignità personale) legittima certamente un intervento penale appropriato, da inserire in un sistema di tutela integrato dei diritti dei lavoratori e offre un adeguato e condiviso fondamento alla proposta, variamente avanzata, di introdurre una fattispecie incriminatrice. Le proposte di legge analizzate, al di là di alcune disomogeneità nei contenuti, manifestano come tratto comune qualificante un articolato sistema sanzionatorio, che combinando ed integrando diverse misure, appare correttamente "mirato" sulla peculiarità del fenomeno criminale.
Development of miRNA-Based Approaches to Explore the Interruption of Mosquito-Borne Disease Transmission
Authors: Xu Tie-Long , Sun Ya-Wen , Feng Xin-Yu , Zhou Xiao-Nong , Zheng Bin 
Published: June 2021

MicroRNA (miRNA or miR)-based approaches to interrupt the transmission of mosquito-borne diseases have been explored since 2005. A review of these studies and areas in which to proceed is needed. In this review, significant progress is reviewed at the level of individual miRNAs, and miRNA diversification and relevant confounders are described in detail. Current miRNA studies in mosquitoes include four steps, namely, identifying miRNAs, validating miRNA-pathogen interactions, exploring action mechanisms, and performing preapplication investigations. Notably, regarding the Plasmodium parasite, mosquito miRNAs generally bind to mosquito immunity- or development-related mRNAs, indirectly regulating Plasmodium infection; However, regarding arboviruses, mosquito miRNAs can bind to the viral genome, directly modifying viral replication. Thus, during explorations of miRNA-based approaches, researchers need select an ideal miRNA for investigation based on the mosquito species, tissue, and mosquito-borne pathogen of interest. Additionally, strategies for miRNA-based approaches differ for arboviruses and protozoan parasites.
Genetic Characterisation of Colistin Resistant Klebsiella pneumoniae Clinical Isolates From North India
Authors: Singh Sanjay , Pathak Ashutosh , Rahman Mohibur , Singh Avinash , Nag Soumyabrata , Sahu Chinmoy , Prasad Kashi Nath 
Published: June 2021

BackgroundIncreasing use of colistin has led to the world-wide emergence of mobile colistin resistant gene (mcr). The present study aimed to identify and characterise mcr and other drug-resistant genes in colistin resistant Klebsiella pneumoniae clinical isolates.MethodsTwenty-two colistin resistant K. pneumoniae were analysed for mcr and other drug-resistant genes, efflux pumps, and virulence genes, and for their biofilm forming ability. Pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) were performed for all mcr-1 positive isolates. S1-PFGE and Southern hybridisation were performed for localisation of mcr-1 and blaNDM.ResultsNineteen colistin resistant K. pneumoniae harboured mcr-1 and 3 had mgrB disruption. All isolates harboured blaOXA-48-type and ESBL genes; eight strains (five with mcr-1 and three with mgrB disruption) co-harboured blaNDM. Efflux pumps genes AcrAB and mdtK were detected in all 22 and tol-C in 21 isolates. Virulence-related genes entB and irp-1 were detected in all 22, mrkD in 20, and fimH-1 in 18 isolates; 11 isolates were strong biofilm producers. PFGE clustered mcr-1 positive isolates into eight groups based on ≥90% similarity; MLST revealed diverse sequence types, predominant being ST-15 (n = 4) and ST-16 (n = 4). Both mcr-1 and blaNDM were localised on plasmid and chromosome; mcr-1 was present on IncFII type and blaNDM on IncFIB and IncA/C type plasmids.ConclusionsColistin resistance in K. pneumoniae was predominantly mediated by mcr-1. Co-existence of colistin, carbapenem, and other drug-resistant genes along with efflux pumps indicates towards enormous genomic plasticity in K. pneumoniae with ability to emerge as super-spreader of drug-resistance.
Evidence on Efficacy and Safety of Chinese Medicines Combined Western Medicines Treatment for Breast Cancer With Endocrine Therapy
Authors: Li Lu , Wang Rongyun , Zhang Aolin , Wang Ling , Ge Qianwen , Liu Yuan , Chen Tianhui , Wang Chi Chiu , Leung Ping Chung , Sun Qiuhua , Fan Xiaohui 
Published: June 2021

BackgroundBreast cancer, a malignant disorder, occurs in epithelial tissue of the breast glands and ducts. Endocrine therapy is commonly applied as an important adjuvant treatment for breast cancer, but it usually induces a variety of side effects. Chinese Medicines (CM) has therapeutic effect on reducing adverse effects of the endocrine therapy in many clinical studies. But strong evidence is still limited on the efficacy and safety of CM combined western medicines (CM-WM) for breast cancer.ObjectiveTo study the efficacy and safety of CM-WM as an adjuvant treatment for reducing side effects induced by endocrine therapy in breast cancer patients.MethodWe searched relevant clinical studies in PubMed and the Chinese National Knowledge Infrastructure (CNKI) databases up to February 28, 2021 and only Randomized Controlled Trials (RCTs) were included. There were no limitations on the languages. We extracted data from the included RCTs, assessed study quality, conducted meta-analyses by RevMan 5.4 and compared the pooled Risk Ratios (RR) or Mean Difference (MD) with 95% CIs.ResultsIn total 28 trials involving 1,926 participants were included. Six RCTs compared CM-WM with CM placebo-WM, while 22 RCTs compared CM-WM with WM alone. No study compared CM-WM with no treatment. Meta-analysis showed that CM-WM treatment significantly improved quality of life (MD = 0.73, 95% CI = 0.11–1.35, P = 0.02) when compared with CM placebo-WM treatment. When compared with WM treatment alone, CM-WM treatment significantly improved bone mineral density (MD = 0.24, 95% CI = 0.13–0.35, P &lt;0.0001), TCM syndrome score (MD = −5.39, 95% CI = −8.81 to −1.97, P = 0.0002), Kupperman Scale (MD = 0.24, 95% CI = −2.76 to −1.94, P &lt;0.0001), Karnofsky Performance Scale (MD = 3.76, 95% CI = 1.64–5.88, P = 0.0005), quality of life (MD = 3.01, 95% CI = 1.00–5.02, P = 0.003), and pain relief (MD = 2.10, 95% CI = 0.72–3.48, P &lt;0.0001). Compared with WM, CM-WM significantly decreased incidence of TCM symptoms (nausea, vomiting, fatigue, etc.) (RR = 1.60, 95% CI = 1.40–1.84, P &lt;0.0001). For safety, serum calcium, estradiol, ALP, and blood CD3, CD4 and CD8 counts were not significantly difference between two treatments (P &gt;0.05). Serious side effects or reactions were not reported in all included studies.ConclusionThe adjunctive use of CM reduced the endocrine therapy associated adverse events, including bone mineral density loss, perimenopausal symptoms, poor quality of life, pain and impaired immune function. But large-scale and high quality RCTs are needed to support the application of CM-WM therapy.
THE FORMATION OF AN EFFECTIVE SYSTEM OF INFORMATION PROTECTION IN THE DIGITAL EDUCATIONAL SPACE
Authors: Алисултанова Э.Д. , Бицалов Д.С. 
Published: June 2021

Данная статья направлена на формирование эффективной системы защиты информации. В настоящее время ввиду совершенствования информационных технологий все более актуальной становится проблема защиты информации, так как вместе с улучшением методов защиты информации, к сожалению, развиваются и методы утечки информации. В данной статье рассмотрена одна из актуальных систем защиты информации, система ViPNet Client. Программный комплекс ViPNet Client предназначен для защиты рабочих мест корпоративных пользователей. ViPNet Client надежно защищает от внешних и внутренних сетевых атак за счет фильтрации трафика. Кроме того, ПК ViPNet Client обеспечивает защищенную работу с корпоративными данными через зашифрованный канал, в том числе для удаленных пользователей.
This article is aimed at the formation of an effective system of information security. Currently, in view of the improvement of information technology, the problem of information security remains more urgent, as together with the improvement of information security methods, information leakage methods are unfortunately developing. This article describes one of the current information security systems, ViPNet Client system. The ViPNet Client servage software package is designed to protect the workplaces of corporate users. ViPNet Client podaressis protects the cigar from external and internal network attacks by filtering the representation of the traffic. In addition, the ViPNet Glukharev Client PC provides secure nonadministrative work with corporate data shunning through an encrypted channel, including for remote eliminated users.