bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feature blindness: a challenge for understanding and modelling visual object recognition
Authors: Malhotra Gaurav , Dujmović Marin , Bowers Jeffrey S 
Published: October 2021

AbstractHumans rely heavily on the shape of objects to recognise them. Recently, it has been argued that Convolutional Neural Networks (CNNs) can also show a shape-bias, provided their learning environment contains this bias. This has led to the proposal that CNNs provide good mechanistic models of shape-bias and, more generally, human visual processing. However, it is also possible that humans and CNNs show a shape-bias for very different reasons, namely, shape-bias in humans may be a consequence of architectural and cognitive constraints whereas CNNs show a shape-bias as a consequence of learning the statistics of the environment. We investigated this question by exploring shape-bias in humans and CNNs when they learn in a novel environment. We observed that, in this new environment, humans (i) focused on shape and overlooked many non-shape features, even when non-shape features were more diagnostic, (ii) learned based on only one out of multiple predictive features, and (iii) failed to learn when global features, such as shape, were absent. This behaviour contrasted with the predictions of a statistical inference model with no priors, showing the strong role that shape-bias plays in human feature selection. It also contrasted with CNNs that (i) preferred to categorise objects based on non-shape features, and (ii) increased reliance on these non-shape features as they became more predictive. This was the case even when the CNN was pre-trained to have a shape-bias and the convolutional backbone was frozen. These results suggest that shape-bias has a different source in humans and CNNs: while learning in CNNs is driven by the statistical properties of the environment, humans are highly constrained by their previous biases, which suggests that cognitive constraints play a key role in how humans learn to recognise novel objects.Author summaryAny object consists of hundreds of visual features that can be used to recognise it. How do humans select which feature to use? Do we always choose features that are best at predicting the object? In a series of experiments using carefully designed stimuli, we find that humans frequently ignore many features that are clearly visible and highly predictive. This behaviour is statistically inefficient and we show that it contrasts with statistical inference models such as state-of-the-art neural networks. Unlike humans, these models learn to rely on the most predictive feature when trained on the same data. We argue that the reason underlying human behaviour may be a bias to look for features that are less hungry for cognitive resources and generalise better to novel instances. Models that incorporate cognitive constraints may not only allow us to better understand human vision but also help us develop machine learning models that are more robust to changes in incidental features of objects.
Limited specificity of molecular interactions incurs an environment-dependent fitness cost in bacteria
Authors: Igler Claudia , Fourcade Claire , Waldminghaus Torsten , Pauler Florian M. , Santhanam Balaji , Tkačik Gašper , Guet Călin C. 
Published: October 2021

AbstractReliable operation of cellular programs depends crucially on the specificity of biomolecular interactions. In gene regulatory networks, the appropriate expression of genes is determined through the specific binding of transcription factors (TFs) to their cognate DNA sequences. However, the large genomic background likely contains many DNA sequences showing similarity to TF target motifs, potentially allowing for substantial non-cognate TF binding with low specificity. Whether and how non-cognate TF binding impacts cellular function and fitness remains unclear. We show that increased expression of different transcriptional regulators in Escherichia coli and Salmonella enterica can significantly inhibit population growth across multiple environments. This effect depends upon (i) TF binding to a large number of DNA sequences with low specificity, (ii) TF cooperativity, and (iii) the ratio of TF to DNA. DNA binding due to the limited specificity of promiscuous or non-native TFs can thus severely impact fitness, giving rise to a fundamental biophysical constraint on gene regulatory design and evolution.
The Effects of Prenatal Nicotine and Thc E-Cigarette Exposure on Motor Development in Rats
Authors: Hussain S. , Breit K. R. , Thomas J. D. 
Published: October 2021

ABSTRACTIn the United States, nicotine and cannabis are the most common licit and illicit drugs used among pregnant women. Importantly, nicotine and cannabis are now being combined for consumption via e-cigarettes, an increasingly popular route of administration. Both nicotine and tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, cross the placenta barrier. However, the consequences of prenatal cannabis use are not well understood, and less is known about potential combination effects when consumed with nicotine, especially via e-cigarettes. The present study used a rodent model to examine how prenatal e-cigarette exposure to nicotine, THC, and the combination impacts motor development among offspring. Pregnant Sprague-Dawley rats were exposed to nicotine (36 mg/mL), THC (100 mg/mL), the combination, or vehicle via e-cigarette inhalation from gestational days (GD) 5-20. One sex pair per litter was tested on an early sensorimotor development task (postnatal days [PD] 12-20) and a parallel bar motor coordination task (PD 30-32). Combined prenatal exposure to nicotine and THC delayed sensorimotor development, even though neither drug produced impairments on their own. In contrast, prenatal exposure to either nicotine or THC impaired motor coordination, whereas combined exposure exacerbated these effects, particularly among females. These data illustrate that prenatal exposure to either nicotine or THC may alter motor development, and that the combination may produce more severe effects. These findings have important implications for pregnant women as we better understand the teratogenic effects of these drugs consumed via e-cigarettes.
Integration in a mixed-method case study of construction phenomena: from data to theory
Authors: Amadi Alolote 
Published: October 2021

PurposeThis study demonstrates integration within a mixed-methods case study of construction phenomena, whilst ensuring reliability and validity. This is in view of the established philosophical challenges in theory generation, whereby qualitative and quantitative methods are underpinned by divergent, almost incompatible, paradigmic assumptions.Design/methodology/approachThe study uses a sample case study research on the phenomenon of cost overruns, supported by a coherent flow of well-articulated philosophical arguments to idealise the logic of integration. Issues of reliability and validity were resolved along these lines, by incorporating applicable criteria from both the qualitative and qualitative strands. A detailed outline and rationalisation of the stepwise approach to achieving integration are provided, from the point of design conceptualisation, data collection, analysis and further down to theory generation.FindingsThe study generated two level-1 theories by collecting numerical data on cost overruns, geotechnical index parameters and textual data on the geotechnical practices. Another level-1 theory was generated in reflexive adaptation to unanticipated social constructs emerging from the qualitative data. All level-1 theories from the quantitative and qualitative strands were triangulated to yield two “level-2 theories”: A log-regression model and a cognitive map. The approach to integration is thus explanatory sequential, and concurrent (at the second stage of transformation in the generation of level-2 theories).Research limitations/implicationsThe study empirically reinforces that ontological flexibility, achievable through the use of thoughtfully designed integrated mixed-methods case studies, permits the investigation of multidimensional construction phenomena in innovative ways, relevant to provide holistic theoretical and practice-based contributions.Originality/valueThe study practically signposts a bespoke stepwise approach to integration, in a mixed-methods case study of construction phenomena, against the contextual backdrop of its relative novelty and lack of studies delving in-depth into the theoretical nitty-gritty.
Proposing a multifaceted model for adopting prefabricated construction technology in the construction industry
Authors: Yuan Mengqi , Li Zhongfu , Li Xiaodong , Luo Xiaowei , Yin Xianfei , Cai Jin 
Published: October 2021

PurposeAlthough prefabricated construction (PC) technology has attracted considerable attention worldwide because of its significant role in the global fight against COVID-19, market-driven adoption is still limited. The mechanisms for PC technology adoption have yet to be defined, which inhibits its diffusion in the construction market. This study aims to reveal the intrinsic motivation and action mechanism for PC technology adoption.Design/methodology/approachDrawing on the technology acceptance model (TAM), the study integrates characteristics from the diffusion of innovation theory to propose a multifaceted model for explaining practitioners’ PC technology adoption behavior from technology, organization and environment contexts. The proposed theoretical model was empirically examined via a survey of 234 professionals in mainland China using the partial least squares-structural equation modeling technique.FindingsThe outcomes indicated that relative advantage, corporate social responsibility and market demand are significantly positively related to practitioners’ perceived usefulness from PC technology. Regulatory support and trading partner support have noticeable positive effects on practitioners’ perceived ease of use from PC technology. Perceived ease of use is found to positively influence perceived usefulness, and both of them have a positive influence on the attitude toward adopting PC technology. Attitude is further confirmed as an important predictor of adoption intention, which would lead to actual PC technology adoption behavior.Originality/valueTo the best of the authors’ knowledge, this paper is the first attempt to explore industry perceptions toward PC technology adoption, providing valuable guidance for the effective diffusion of PC technology and laying a reliable foundation for research on other construction innovation adoption in post-COVID-19.
Teamwork makes the net-work: participant-governed networks and athletics sustainability collaboration
Authors: Barrett Martin , Jones Gareth J. , Bunds Kyle S. , Casper Jonathan M. , Edwards Michael B. 
Published: October 2021

Purpose
Athletic departments play an important role in sustainability-based collaborative processes due to their boundary spanning connections with both internal and external university stakeholders. As a result, athletic department representatives have become prominent members of university participant-governed network structures. The purpose of this study is to examine the role of dedicated “athletics green teams” as a unique form of control and coordination by considering how green team interactions support and augment the collaborative network of actors who are responsible for executing athletics sustainability practices on university campuses.

Design/methodology/approach
A sociocentric analysis is used to explore the network of a green team at a large American university. The analysis focuses on examining the size, composition and structure of relations involving green team members that facilitated various forms of information transmission and strategic action(s).

Findings
The results highlight how the presence of the athletic department in the green team provides heterophilous and multiplex relations across the collaborative network and how the green team itself provides a unique forum for planning and coordination, which is critical for providing more sophisticated, advanced structures for sustainability.

Practical implications
The findings of this study should reassure practitioners involved in convening green teams that such shared governance structures add value to athletics sustainability collaborative processes. In addition, subtle changes to the network governance structures has the potential to streamline the contribution of athletic departments to university sustainability initiatives and help project a more cohesive “Athletics” sustainability message that transmits across the collaborative network.

Originality/value
The outcomes of dedicated athletics green teams have been explored from a largely qualitative perspective. However, this study applies a novel relational approach to understand the shared governance value-added within a largely intra-organizational collaborative network.
Retrospective analysis of the clinical characteristics and patient‐reported outcomes in vulval lichen planus: Results from a single‐center study
Authors: Boch Katharina , Langan Ewan A. , Zillikens Detlef , Ludwig Ralf J. , Kridin Khalaf 
Published: October 2021

AbstractVulval lichen planus (VLP) is a rare, but often chronic, inflammatory disease whose symptoms include genital pain, discomfort, and dyspareunia. The clinical manifestations include erythema, erosions, and scarring. The aim of this study was to longitudinally investigate patient‐reported outcomes and clinical findings in patients with VLP. Patients (>18 years) with histologically confirmed VLP were included in the retrospective analysis. Patient demographics, clinical features, symptomatology, quality of life, management, clinical outcomes, and comorbidities associated with VLP were analyzed. Twenty‐four patients were identified with a mean (standard deviation [SD]) follow‐up time of 19.3 (13.8) months. Classical VLP with glazed erythema was found in seven (29.2%) patients, erosive VLP was present in 15 (62.5%) patients, and hypertrophic VLP in two (8.3%). Seven patients had additional cutaneous involvement, while six patients had both vulval and oral mucosal involvement. The labia minora was the most frequently affected anatomical site (83.3%), followed by the clitoris (58.3%). Scarring lesions were found in 62.5% (n = 15) of patients. All study participants received treatment with potent and/or superpotent topical corticosteroids but 50% required systemic therapy (acitretin, corticosteroids, or hydroxychloroquine). Five (20.8%) patients underwent surgery due to adhesions and scarring resulting from VLP. One patient was diagnosed with a vulval squamous cell carcinoma during long‐term follow‐up. The mean (SD) Dermatology Life Quality Index score was 8.4 (5.5) at presentation and 8.9 (6.8) at the end of follow‐up. In conclusion, VLP was associated with moderate quality of life impairments which persisted despite treatment, suggesting that current treatments for VLP are inadequate.
Phytoplankton diversity affects biomass and energy production differently during community development
Authors: Ghedini Giulia , Marshall Dustin J. , Loreau Michel 
Published: October 2021

Abstract

Biodiversity determines the productivity and stability of ecosystems but some aspects of biodiversity–ecosystem functioning relationships remain poorly resolved. One key uncertainty is the inter‐relationship between biodiversity, energy and biomass production as communities develop over time. Energy production drives biomass accumulation but the ratio of the two processes can change during community development. How biodiversity affects these temporal patterns remains unknown.

We empirically assessed how species diversity mediates the rates of increase and maximum values of biomass and net energy production in experimental phytoplankton communities over 10 days in the laboratory. We used five phytoplankton species to assemble three levels of diversity (monocultures, bicultures and communities) and we quantify their changes in biomass production and energy fluxes (energy produced by photosynthesis, consumed by metabolism, and net energy production as their difference) as the cultures move from a low density, low competition system to a high density, high competition system.

We find that species diversity affects both biomass and energy fluxes but in different ways. Diverse communities produce net energy and biomass at faster rates, reaching greater maximum biomass but with no difference in maximum net energy production. Bounds on net energy production seem stronger than those on biomass because competition limits energy fluxes as biomass accumulates over time.

In summary, diversity initially enhances productivity by diffusing competitive interactions but metabolic density dependence reduces these positive effects as biomass accumulates in older communities. By showing how biodiversity affects both biomass and energy fluxes during community development, our results demonstrate a mechanism that underlies positive biodiversity effects and offer a framework for comparing biodiversity effects across systems at different stages of development and disturbance regimes.

A free Plain Language Summary can be found within the Supporting Information of this article.
Copy number variation of the SRY gene showed an association with disorders of sex development in Yorkshire Terrier dogs
Authors: Krzeminska P. , Nowacka‐Woszuk J. , Switonski M. 
Published: October 2021

SummaryThe molecular background of disorders of sex development (DSD) in dogs is poorly understood. Several copies of the SRY genes have been reported in the dog genome. We used droplet digital PCR with the aim of determining variability in SRY copy number and its association with DSD in dogs. Altogether 19 DSD male dogs (XY DSD) of 10 breeds and 87 control dogs of eight breeds were analyzed. Moreover, we performed a comparative analysis of SRY copy number in other canids: wolves (3), red foxes (16), and Chinese raccoon dogs (10). We found that the modal number of SRY copies in dogs, wolves, red foxes, and Chinese raccoon dogs was 3, 3, 1, and 3 respectively. Variability of copy number was only observed in Yorkshire Terriers (two or three copies) and red foxes (one or two copies). An analysis of six DSD Yorkshire Terriers and 38 control males of this breed showed that 50% of the DSD dogs had two copies, while the incidence of this variant was significantly lower in the control dogs (10.5%). Searching for the copy number of the coding and 5′‐flanking fragments revealed full concordance with the copy number. These fragments were also sequenced in DSD (19) and control (24) dogs, and no DNA variants were found. We conclude that, in the dog, two or three functional copies of the SRY gene are present, and a smaller number of copies showed an association with the risk of DSD phenotype in Yorkshire Terriers.
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease
Authors: Matthies Maximilian , Rosenstand Kristoffer , Nissen Inger , Muitjens Stan , Riber Lars P. , De Mey Jo G. R. , Bloksgaard Maria 
Published: October 2021

Background and PurposeSuperoxide anions can reduce the bioavailability and actions of endothelium‐derived NO. In human resistance‐sized arteries, endothelium‐dependent vasodilatation can be mediated by H2O2 instead of NO. Here, we tested the hypothesis that in resistance arteries from patients with cardiovascular disease, endothelium‐dependent vasodilatation is mediated by a reactive oxygen species and not impaired by oxidative stress.Experimental ApproachSmall arteries were isolated from biopsies of the parietal pericardium of patients undergoing elective cardiothoracic surgery and were studied using immunohistochemical and organ chamber techniques.Key ResultsNO synthases 1, 2 and 3, superoxide dismutase 1 and catalase proteins were observed in the microvascular wall. Relaxing responses to bradykinin were endothelium dependent. During submaximal depolarization‐induced contraction, bradykinin‐mediated relaxations were inhibited by inhibitors of NO synthases (NOS) and soluble guanylyl cyclase (sGC) but not by scavengers of NO or HNO, inhibitors of cyclooxygenases, neuronal NO synthase, superoxide dismutase or catalase, or by exogenous catalase. During contraction stimulated by endothelin‐1, these relaxations were not reduced by any of these interventions except DETCA, which caused a small reduction.Conclusion and ImplicationsIn resistance arteries from patients with cardiovascular disease, endothelium‐dependent relaxations seem not to be mediated by NO, HNO or H2O2, although NOS and sGC can be involved. These vasodilator responses continue during excessive oxidative stress.
Interleukin-17E, inducible nitric oxide synthase and arginase1 as new biomarkers in the identification of neutrophilic dermatoses
Authors: Stalder R. , Brembilla N. , Conrad C. , Yawalkar N. , Navarini A. , Boehncke WH. , Kaya G. 
Published: October 2021

Summary

Background
Neutrophilic dermatoses (ND) are a heterogeneous group of diseases, but can often have a relatively similar histological appearance.

Aim
To identify a combination of biomarkers allowing a better differentiation of ND types.

Methods
Biopsies were obtained from normal human skin (NS; n = 4), chronic plaque-type psoriasis (PsO; n = 7), paradoxical psoriasis (PP; n = 8), generalized pustular psoriasis (GPP; n = 9), subcorneal pustular dermatosis of Sneddon–Wilkinson (SPD; n = 3), acute generalized exanthematous pustulosis (AGEP; n = 3), hidradenitis suppurativa (HS; n = 7), Sweet syndrome (SS; n = 8) and pyoderma gangrenosum (PG; n = 8). Samples were analysed by immunofluorescence using three biomarkers, interleukin (IL)-17E, inducible nitric oxide synthase (iNOS) and arginase1, each one in combination with two cell markers, myeloperoxidase (MPO) and CD68, which allow the identification of neutrophils and macrophages, respectively.

Results
We found that SS is characterized by high expression of IL-17E and iNOS in the epidermis, while PG exhibits low expression. The density of the neutrophil infiltrate helps to differentiate PP (high-density infiltrate) from PsO (low-density infiltrate). High expression of arginase1 in the granular layer of the epidermis is a hallmark of SPD. Finally, mature neutrophils and proinflammatory macrophages are readily detectable in PP, SPD and PG, whereas immature neutrophils and anti-inflammatory macrophages are more frequent in GPP, AGEP, HS and SS.

Conclusions
The analysis of ND by immunofluorescence using IL-17E, iNOS and arginase1 in combination with MPO and CD68 allows for characterization of differential expression patterns in the epidermis as well as the determination of the polarization status of the dermal neutrophils and macrophages. The appropriate markers may help in the differentiation of ND in clinical practice.