bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Access to Amides from Nitro‐Compounds via Aminocarbonylation and Amidation Reactions: A Minireview
Authors: Barak Dinesh S. , Batra Sanjay 
Published: September 2021

AbstractThe ubiquity of the amide bond in functional molecules including proteins, natural products, pharmaceuticals, agrochemicals and materials provides impetus to design and develop newer strategies for the generation of this linkage. Owing to growing awareness about sustainability and development of benign strategies, the traditional route of synthesis of amides via reaction between carboxylic acids and amines in the presence of stoichiometric amount of coupling reagents is tagged to be harsh and wasteful. In one of the unconventional routes, nitro compounds are used directly as amine surrogates for preparing amides mostly via aminocarbonylation and amidation reactions. Typically, such processes involves nitroarenes owing to their propensity to transform into nitroso, hydroxylamine, diazo, hydrazine or aniline intermediates in situ under the influence of suitable catalyst or oxidant. This short review provides the comprehensive overview of these reactions including insight into the scope and their mechanisms.
Comment: China's Shaxian Snacks: A national brand's globalization challenge
Authors: Allen Lawrence L. 
Published: September 2021

AbstractChina is 91% Han Chinese and has a deeply rooted cultural penchant for obedience to authority. Less homogeneous nations that are accustomed to individual liberty may find some of China's techniques and approaches counter to their culture. This cross‐cultural phenomenon cuts all ways. Shaxian Snacks' is a fascinating example of a coming together of high‐functioning, public–private parts of the Chinese economy in ways unique to China.
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma
Authors: Balaraman Gopalakrishnan , Sundaram Jagan , Mari Ashok , Krishnan Palanisamy , Salam Sharmila , Subramaniam Nirmala , Sirajduddin Immaduddin , Thiruvengadam Devaki 
Published: September 2021

AbstractHepatocellular carcinoma is a well‐known internal malignancy with increased worldwide mortality. The increased progression rate is closely associated with chronic liver diseases such as cirrhosis. Chemical carcinogens cause tumor advocacy over free radical metabolites to causes numerous biochemical and molecular changes that bring oxidative stress. In addition, inflammatory cells and its growth factor promotes the progression of liver cancer through deregulates the numerous cellular signaling pathways involved in normal cellular proliferation. Plant derived phytochemicals have a better complimentary potency to defend against a wide array of free radical mediated diseases such as cancer. More recently, we have evaluated the anticancer effect of Farnesol against DEN induced hepatocellular carcinoma in male wistar albino rats. However, the possible mechanism in which Farnesol attributes its anticancer effect against DEN induced liver cancer remains unknown. Hence in the present study, an attempt has been made to reduce the oxidative stress by appraise the antioxidant effect by Farnesol in DEN induced hepatocellular carcinoma. Elevated oxidative stress markers with concomitant decreased cellular antioxidants levels were observed in DEN induced hepatic tissues. Further, proliferating nuclei with increased proliferating cell nucleolar antigen (PCNA) and inflammatory mediator expression were observed in DEN induced rats. Oral supplementation of Farnesol to DEN induced rats significantly decrease the oxidative stress markers and increase the cellular antioxidant status. Moreover, Farnesol treatment decreases the argyrophilic nuclear organizer region and PCNA along with decreased expression of inflammatory mediators suggest that Farnesol treatment restores DEN induced hepatic abnormalities and protects liver from cancer progression.
Developing a non‐invasive method of detecting elephant endotheliotropic herpesvirus infections using faecal samples
Authors: Common Sophie M. , Yun Yaoprapa , Silva‐Fletcher Ayona , Thitaram Chatchote , Janyamethakul Thittaya , Khammesri Siripat , Molenaar Fieke M. 
Published: September 2021

AbstractBackgroundElephant endotheliotropic herpesvirus (EEHV)‐associated haemorrhagic disease (EEHV‐HD) is a leading cause of death in Asian elephant calves across the world. Cases of EEHV‐HD have been detected in free‐living calves through post‐mortem examination (PME) indicating the presence of the virus in the wild. In the absence of a non‐invasive sampling method, little research into free‐living populations has been possible. This study aimed to provide evidence that faeces can be used as a non‐invasive sampling method for the detection of EEHV excretion using quantitative polymerase chain reaction.MethodsSerial saliva swabs and faecal samples were taken from five captive Asian elephants in Thailand over 12 weeks. To ensure the presence of detectable elephant DNA within the sample, qPCR was run for amplification of the Asian elephant tumour necrosis factor (TNF‐α) gene, EEHV1 and EEHV4.ResultsOf 28 sample pairs, seven saliva samples were positive for EEHV, of which two had paired positive faecal samples.ConclusionsThis study presents the first evidence that EEHV is excreted in faeces at detectable levels. This method may in future be used for improved understanding of the epidemiology of EEHV in free‐living elephant populations, as well as detection of EEHV excretion in captive herds.
Usage of meat and bone meal in animal, poultry and fish feeds: A survey and risk analysis for the occurrence of bovine spongiform encephalopathy in Bangladesh
Authors: Islam Md. Nazrul , Siddiqui Md. Saiful Islam , Islam Md. Taohidul , Islam Md. Rafiqul , Chowdhury Emdadul Haque 
Published: September 2021

AbstractBackgroundBovine spongiform encephalopathy (BSE) is an emerging zoonotic disease of cattle associated with pathological prion protein (PrPsc) transmitted via meat and bone meal (MBM). Although Bangladesh did not experience a BSE outbreak but the country could not export animal products to developed countries as has not yet been declared BSE free country by OIE due to lack of scientific risk evaluation for BSE. The objectives were identification of hazard, release and exposure pathways of pathological prion protein through MBM and analysis of risk for the occurrence of BSE in Bangladesh.MethodsThe scientific data were reviewed, hazards were scheduled and surveys were conducted on livestock production system, import of MBM and its use to identify the hazards present in Bangladesh context. The analysis was done by the ‘OIE Risk Analysis Framework 2006 and European Union (EU) Scientific Steering Committee (SSC) 2003’. From the historical reviews, import of MBM and its use was identified, as external hazards.ResultsThe analysis revealed that these hazards had negligible or moderate risk for the introduction of infectious PrPsc as Bangladeshi cattle are vegetarian cattle. No milk replacer was used and use of slaughtered waste in the animal feed industry is absent. Unconsumable bones are processed to produce bone chips, fertilizers and bone meal for poultry feeds. Scrapie was never prevalent in Bangladesh. Therefore, risk from the internal challenge was negligible in Bangladesh for the occurrence of classical BSE. These prevented the propagation of BSE infectivity and eliminated BSE infectivity from the system very fast, if that was present.ConclusionsIt was concluded that introduction of PrPsc into cattle population of Bangladesh through MBM was very negligible. Therefore, Bangladesh can be considered as BSE negligible risk country.
Yeasts in the attine ant–fungus mutualism: Diversity, functional roles, and putative biotechnological applications
Authors: Bizarria Rodolfo , Pagnocca Fernando Carlos , Rodrigues Andre 
Published: September 2021

AbstractInsects interact with a wide variety of yeasts, often providing a suitable substrate for their growth. Some yeast–insect interactions are tractable models for understanding the relationships between the symbionts. Attine ants are prominent insects in the Neotropics and have performed an ancient fungiculture of mutualistic basidiomycete fungi for more than 55–65 million years. Yeasts gain access to this sophisticated mutualism, prompting diversity, ecological, and biotechnological studies in this environment. We review half a century research in this field, surveying for recurrent yeast taxa and their putative ecological roles in this environment. We found that previous studies mainly covered the yeast diversity from a small fraction of attine ants, being Saccharomycetales, Tremellales, and Trichosporonales as the most frequent yeast or yeast‐like orders found. Apiotrichum, Aureobasidium, Candida, Cutaneotrichosporon, Debaryomyces, Meyerozyma, Papiliotrema, Rhodotorula, Trichomonascus, and Trichosporon are the most frequent recovered genera. On the other hand, studies of yeasts’ ecological roles on attine ant–fungus mutualism only tapped the tip of the iceberg. Previous established hypotheses in the literature cover the production of lignocellulosic enzymes, chemical detoxification, and fungus garden protection. Some of these roles have parallels in biotechnological processes. In conclusion, the attine ant environment has a hidden potential for studying yeast biodiversity, ecology, and biotechnology, which has been particularly unexplored considering the vast diversity of fungus‐growing ants.
Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
Authors: Díez-Sainz Ester , Milagro Fermín I. , Riezu-Boj José I. , Lorente-Cebrián Silvia 
Published: September 2021

AbstractObesity and diabetes incidence rates are increasing dramatically, reaching pandemic proportions. Therefore, there is an urgent need to unravel the mechanisms underlying their pathophysiology. Of particular interest is the close interconnection between gut microbiota dysbiosis and obesity and diabetes progression. Hence, microbiota manipulation through diet has been postulated as a promising therapeutic target. In this regard, secretion of gut microbiota–derived extracellular vesicles is gaining special attention, standing out as key factors that could mediate gut microbiota-host communication. Extracellular vesicles (EVs) derived from gut microbiota and probiotic bacteria allow to encapsulate a wide range of bioactive molecules (such as/or including proteins and nucleic acids) that could travel short and long distances to modulate important biological functions with the overall impact on the host health. EV-derived from specific bacteria induce differential physiological responses. For example, a high-fat diet–induced increase of the proteobacterium Pseudomonas panacis–derived EV is closely associated with the progression of metabolic dysfunction in mice. In contrast, Akkermansia muciniphila EV are linked with the alleviation of high-fat diet–induced obesity and diabetes in mice. Here, we review the newest pieces of evidence concerning the potential role of gut microbiota and probiotic-derived EV on obesity and diabetes onset, progression, and management, through the modulation of inflammation, metabolism, and gut permeability. In addition, we discuss the role of certain dietary patterns on gut microbiota–derived EV profile and the clinical implication that dietary habits could have on metabolic diseases progression through the shaping of gut microbiota–derived EV.
International Business Strategy
Authors: Verbeke Alain , Lee I. H. Ian 
Published: September 2021

Now in its third edition, this core textbook for advanced undergraduate, graduate, and postgraduate students combines analytical rigour and managerial insight on the functioning and strategy of large multinational enterprises (MNEs). Verbeke and Lee develop an original conceptual model that supports student learning by providing an integrated perspective, rooted in theory and practice. The discussion also includes unique commentaries on seventy-four seminal articles published in the Harvard Business Review, the Sloan Management Review, and the California Management Review over the past four decades, demonstrating how the key insights can be applied to real businesses engaged in international expansion programmes, especially as they venture into high-distance markets. This third edition has been thoroughly updated and features new sections on multinational entrepreneurship, strategic challenges in the new economy, and international business strategy during globally disruptive events, including the COVID-19 pandemic. Students will benefit from updated case studies, improved learning features, and a wide range of online resources.
Abnormal Intracortical Functions in Parkinson’s Disease with Rapid Eye Movement Sleep Behaviour Disorder
Authors: Bhattacharya Amitabh , Kamble Nitish , Yadav Ravi , Stezin Albert , Pal Pramod Kumar 
Published: September 2021

ABSTRACT:Background:Rapid eye movement sleep behaviour disorder (RBD) is considered to be one of the most frequent and important prodromal symptoms of Parkinson’s disease (PD). We aimed to study the neurophysiological abnormalities in patients of PD-RBD and PD without RBD (PD-nRBD) using transcranial magnetic stimulation (TMS).Methods:Twenty patients each of PD-RBD and PD-nRBD were included in the study in addition to 20 age and gender-matched healthy controls. RBD was identified using the RBD screening questionnaire (RBDSQ). All the subjects were evaluated with single and paired-pulse TMS and parameters such as resting motor threshold (RMT), central motor conduction time (CMCT), silent period (SP), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were recorded.Results:The mean age of the controls and PD patients with and without RBD was comparable. There were no significant differences in RMT, CMCT and silent period between the two patient groups. SICI was present in all the three groups with significant inhibition noted in PD-RBD group (p < 0.001). ICF was absent in patients of PD-RBD (0.19 ± 0.11) and PD-nRBD (0.7 ± 0.5) when compared to controls (1.88 ± 1.02) with profound impairment in patients with PD-RBD (p < 0.001). The mean MoCA score was found to be significantly different in all the three groups with a worse score in patients with RBD (23.10 ± 2.55; p < 0.001).Conclusions:PD-RBD patients have significantly greater inhibition and reduced intracortical facilitation suggesting enhanced GABAergic and reduced glutaminergic transmission. These abnormalities may underlie the different pathophysiological process observed in these patients.
The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: A summary of data reported to the National Healthcare Safety Network
Authors: Weiner-Lastinger Lindsey M. , Pattabiraman Vaishnavi , Konnor Rebecca Y. , Patel Prachi R. , Wong Emily , Xu Sunny Y. , Smith Brittany , Edwards Jonathan R. , Dudeck Margaret A. 
Published: September 2021

AbstractObjectives:To determine the impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare-associated infection (HAI) incidence in US hospitals, national- and state-level standardized infection ratios (SIRs) were calculated for each quarter in 2020 and compared to those from 2019.Methods:Central–line–associated bloodstream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), ventilator-associated events (VAEs), select surgical site infections, and Clostridioides difficile and methicillin-resistant Staphylococcus aureus (MRSA) bacteremia laboratory-identified events reported to the National Healthcare Safety Network for 2019 and 2020 by acute-care hospitals were analyzed. SIRs were calculated for each HAI and quarter by dividing the number of reported infections by the number of predicted infections, calculated using 2015 national baseline data. Percentage changes between 2019 and 2020 SIRs were calculated. Supporting analyses, such as an assessment of device utilization in 2020 compared to 2019, were also performed.Results:Significant increases in the national SIRs for CLABSI, CAUTI, VAE, and MRSA bacteremia were observed in 2020. Changes in the SIR varied by quarter and state. The largest increase was observed for CLABSI, and significant increases in VAE incidence and ventilator utilization were seen across all 4 quarters of 2020.Conclusions:This report provides a national view of the increases in HAI incidence in 2020. These data highlight the need to return to conventional infection prevention and control practices and build resiliency in these programs to withstand future pandemics.
The role of school counsellors in children’s adjustment to preschool education
Authors: Öngören Sema 
Published: September 2021

AbstractThis research aims to examine the practices of school counsellors working in preschool education towards children’s school adjustment in academic, social, emotional, and behavioural dimensions. The research is a qualitative study with participants consisting of 30 school counsellors working in preschool education. The participants were determined using the criterion sampling method, which is a purposeful sampling method. The data were collected using an interview form with four questions. These data were analysed by content analysis method. It was revealed that the counsellors carried out various practices in academic, social, emotional, and behavioural areas for the adjustment of children to school. It was found that academic adjustment activities were cooperation with the family, individual guidance, and behaviour assessment. Social adjustment activities were social skills activities, group guidance, peer support, and individual guidance. Emotional adjustment activities were individual guidance and cooperation with the family. Behavioural adjustment activities were group guidance, cooperation with the family, individual guidance, school rules, and behaviour assessment.
Do star employees help or hinder department performance: the case of surgeons in South Korean hospitals
Authors: Oh Sangsuk , Park Owwon , Hong Woonki 
Published: September 2021

AbstractBased on strategic human capital theory, this study examines the effects of star surgeons on two different types of healthcare outcomes (i.e., number of surgical patients and length of patients’ in-hospital stay after surgery) in the surgery department. We also explore whether the relationship between star surgeons and healthcare outcomes is contingent on the expertise disparity between star and non-star surgeons. The results of an empirical analysis on colorectal cancer surgeons in 80 departments in South Korean hospitals show that the number of star surgeons increases the number of surgical patients and reduces the length of patients' stay after surgery. Moreover, the positive relationship between star surgeons and the number of surgical patients is strengthened when the expertise disparity between star and non-star surgeons is low. The implications of these findings for research and practice are also discussed.
Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death: a Swedish national study
Authors: Kendler Kenneth S. , Ohlsson Henrik , Mościcki Eve K. , Sundquist Jan , Edwards Alexis C. , Sundquist Kristina 
Published: September 2021

AbstractBackgroundHow does genetic liability to suicide attempt (SA), suicide death (SD), major depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use disorder (AUD), and drug use disorder (DUD) impact on risk for SA and SD?MethodsIn the Swedish general population born 1932–1995 and followed through 2017 (n = 7 661 519), we calculate family genetic risk scores (FGRS) for SA, SD, MD, BD, SZ, AUD, and DUD. Registration for SA and SD was assessed from Swedish national registers.ResultsIn univariate and multivariate models predicting SA, FGRS were highest for SA, AUD, DUD, and MD. In univariate models predicting SD, the strongest FGRS were AUD, DUD, SA, and SD. In multivariate models, the FGRS for SA and AUD were higher in predicting SA while the FGRS for SD, BD, and SZ were higher in predicting SD. Higher FGRS for all disorders significantly predicted both younger age at first SA and frequency of attempts. For SD, higher FGRS for MD, AUD, and SD predicted later age at SD. Mediation of FGRS effects on SA and SD was more pronounced for SD than SA, strongest for AUD, DUD, and SZ FGRS and weakest for MD.ConclusionsFGRS for both SA and SD and for our five psychiatric disorders impact on risk for SA and SD in a complex manner. While some of the impact of genetic risk factors for psychiatric disorders on risk for SA and SD is mediated through developing the disorders, these risks also predispose directly to suicidal behaviors.
A herringbone soft pneu-net actuator for enhanced conformal gripping
Authors: Zhang Xinjie , Oseyemi Ayobami Elisha 
Published: September 2021

AbstractAdvances in material science in recent years have had such a tremendous impact on the field of soft robotics that has fostered the development of many bio-inspired devices. One such device, which has been subject to extensive study in recent times, is soft pneumatic-network (pneu-net) actuators (SPAs). In this study, we present a new SPA structure whose chamber configuration mimics the fish bone (herringbone) structure to facilitate simultaneous bending deformations in both longitudinal and transverse directions. Such as cannot be obtained from the regular pneu-net structure – which bends only lengthwise, the coupled bending curvatures allow for gripping with maximized contact area, a property which facilitates firmness, security, and stability in gripping. Using the corresponding chamber inclination angle of the configuration as key parameter, the combined transverse and longitudinal deformation feature is studied through finite element simulation as well as experiments. Also, the functional behavior of the actuator/gripper prototypes is experimentally investigated using a series of approaches including blocked (or tip) force test, grip strength test, and stability (or sustained grasping force) test. Furthermore, the viability of the said conformal gripping characteristic is demonstrated by subjecting the structure to a couple of gripping tests. This utility-enhancing design approach could really guide into the development of more sophisticated application-custom soft robotic capabilities.