bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interphotoreceptor coupling: an evolutionary perspective
Authors: Cangiano Lorenzo , Asteriti Sabrina 
Published: May 2021

AbstractIn the vertebrate retina, signals generated by cones of different spectral preference and by highly sensitive rod photoreceptors interact at various levels to extract salient visual information. The first opportunity for such interaction is offered by electrical coupling of the photoreceptors themselves, which is mediated by gap junctions located at the contact points of specialised cellular processes: synaptic terminals, telodendria and radial fins. Here, we examine the evolutionary pressures for and against interphotoreceptor coupling, which are likely to have shaped how coupling is deployed in different species. The impact of coupling on signal to noise ratio, spatial acuity, contrast sensitivity, absolute and increment threshold, retinal signal flow and colour discrimination is discussed while emphasising available data from a variety of vertebrate models spanning from lampreys to primates. We highlight the many gaps in our knowledge, persisting discrepancies in the literature, as well as some major unanswered questions on the actual extent and physiological role of cone-cone, rod-cone and rod-rod communication. Lastly, we point toward limited but intriguing evidence suggestive of the ancestral form of coupling among ciliary photoreceptors.
Glazunov’s electrography—the first electrochemical imaging and the first solid-state electroanalysis
Authors: Scholz Fritz 
Published: May 2021

AbstractAleksandr Il’ich Glazunov developed the first electrochemical technique to image the surface of conducting solids giving the technique the name electrography. The electrographic images can mirror the distribution of elements on the surface of solid materials and also the electrochemical activity, caused by variations of “dissolution tension”. Thus, he has established for the first time a kind of spatially resolved electrochemistry. Electrography is also the first direct electroanalytical technique for solid materials. The present paper gives an account of his turbulent life in Russia, Czechoslovakia and Chile, and a discussion of his main scientific achievement, the development of electrography.
A Spin-Perturbation for Minimal Surfaces
Authors: Wu Ruijun 
Published: May 2021

AbstractWe investigate the coupling of the minimal surface equation with a spinor of harmonic type. This arises as the Euler–Lagrange equations of the sum of the volume functional and the Dirac action, defined on an appropriated Dirac bundle. The solutions show a relation to Dirac-harmonic maps under some constraints on the energy-momentum tensor, extending the relation between Riemannian minimal surface and harmonic maps.
Power law model for subjective mental workload and validation through air traffic control human-in-the-loop simulation
Authors: Fürstenau Norbert , Radüntz Thea 
Published: May 2021

AbstractWe provide evidence for a power law relationship between the subjective one-dimensional Instantaneous Self Assessment workload measure (five-level ISA-WL scale) and the radio communication of air traffic controllers (ATCOs) as an objective task load variable. It corresponds to Stevens’ classical psychophysics relationship between physical stimulus and subjective response, with characteristic power law exponent γ of the order of 1. The theoretical model was validated in a human-in-the loop air traffic control simulation experiment with traffic flow as environmental stimulus that correlates positively with ATCOs frequency and duration of radio calls (task load, RC-TL) and their reported ISA-WL. The theoretical predictions together with nonlinear regression-based model parameter estimates expand previously published results that quantified the formal logistic relationship between the subjective ISA measure and simulated air traffic flow (Fürstenau et al. in Theor Issues Ergon Sci 21(6): 684–708, 2020). The present analysis refers to a psychophysics approach to mental workload suggested by (Gopher and Braune in Hum Factors 26(5): 519–532, 1984) that was recently used by (Bachelder and Godfroy-Cooper in Pilot workload esimation: synthesis of spectral requirements analysis and Weber's law, SCL Tech, San Diego, 2019) for pilot workload estimation, with a corresponding power law exponent in the typical range of Stevens’ exponents. Based on the hypothesis of cognitive resource limitation, we derived the power law by combination of the two logistic models for ISA-WL and communication TL characteristics, respectively. Despite large inter-individual variance, the theoretically predicted logistic and power law parameter values exhibit surprisingly close agreement with the regression-based estimates (for averages across participants). Significant differences between logistic ISA-WL and RC-TL scaling parameters and the corresponding Stevens exponents as ratio of these parameters quantify the TL/WL dissociation with regard to traffic flow. The sensitivity with regard to work conditions of the logistic WL-scaling parameter as well as the power law exponent was revealed by traffic scenarios with a non-nominal event: WL sensitivity increased significantly for traffic flow larger than a critical value. Initial analysis of a simultaneously measured new neurophysiological (EEG) load index (dual frequency head maps, DFHM, (Radüntz in Front Physiol 8: 1–15, 2017)) provided evidence for the power law to be applicable to the DFHM load measure as well.
Tumor-associated epilepsy in patients with brain metastases: necrosis-to-tumor ratio forecasts postoperative seizure freedom
Authors: Bahna Majd , Heimann Muriel , Bode Christian , Borger Valeri , Eichhorn Lars , Güresir Erdem , Hamed Motaz , Herrlinger Ulrich , Ko Yon-Dschun , Lehmann Felix , Potthoff Anna-Laura , Radbruch Alexander , Schaub Christina , Surges Rainer , Weller Johannes , Vatter Hartmut , Schäfer Niklas , Schneider Matthias , Schuss Patrick 
Published: May 2021

AbstractSurgical resection is highly effective in the treatment of tumor-related epilepsy (TRE) in patients with brain metastases (BM). Nevertheless, some patients suffer from postoperative persistent epilepsy which negatively impacts health-related quality of life. Therefore, early identification of patients with potentially unfavorable seizure outcome after BM resection is important. Patients with TRE that had undergone surgery for BM at the authors’ institution between 2013 and 2018 were analyzed with regard to preoperatively identifiable risk factors for unfavorable seizure outcome. Tumor tissue and tumor necrosis ratios were assessed volumetrically. According to the classification of the International League Against Epilepsy (ILAE), seizure outcome was categorized as favorable (ILAE 1) and unfavorable (ILAE 2–6) after 3 months in order to avoid potential interference with adjuvant cancer treatment. Among all 38 patients undergoing neurosurgical treatment for BM with concomitant TRE, 34 patients achieved a favorable seizure outcome (90%). Unfavorable seizure outcome was significantly associated with larger tumor volumes (p = 0.012), a midline shift > 7 mm (p = 0.025), and a necrosis/tumor volume ratio > 0.2 (p = 0.047). The present study identifies preoperatively collectable risk factors for unfavorable seizure outcome in patients with BM and TRE. This might enable to preselect for highly vulnerable patients with postoperative persistent epilepsy who might benefit from accompanying neuro-oncological expertise during further systemical treatment regimes.
Applying matrix factorization to consistency-based direct diagnosis
Authors: Polat Erdeniz Seda , Felfernig Alexander , Atas Muesluem 
Published: May 2021

AbstractConfiguration systems must be able to deal with inconsistencies which can occur in different contexts. Especially in interactive settings, where users specify requirements and a constraint solver has to identify solutions, inconsistencies may more often arise. In inconsistency situations, there is a need of diagnosis methods that support the identification of minimal sets of constraints that have to be adapted or deleted in order to restore consistency. A diagnosis algorithm’s performance can be evaluated in terms of time to find a diagnosis (runtime) and diagnosis quality. Runtime efficiency of diagnosis is especially crucial in real-time scenarios such as production scheduling, robot control, and communication networks. However, there is a trade off between diagnosis quality and the runtime efficiency of diagnostic reasoning. In this article, we deal with solving the quality-runtime performance trade off problem of direct diagnosis. In this context, we propose a novel learning approach based on matrix factorization for constraint ordering. We show that our approach improves runtime performance and diagnosis quality at the same time.
Carbon isotopic composition of Frutexites in subseafloor ultramafic rocks
Authors: Neubeck Anna , Ivarsson Magnus , Broman Curt , Lima-Zaloumis Jonathan , Bach Wolfgang , Whitehouse Martin 
Published: May 2021

AbstractMicrometer sized stromatolitic structures called Frutexites are features observed in samples from the deep subsurface, and hot-spring environments. These structures are comprised of fine laminations, columnar morphology, and commonly consist of iron oxides, manganese oxides, and/or carbonates. Although a biological origin is commonly invoked, few reports have shown direct evidence of their association with microbial activity. Here, we report for the first time the occurrence of subsurface manganese-dominated Frutexites preserved within carbonate veins in ultramafic rocks. To determine the biogenicity of these putative biosignatures, we analyzed their chemical and isotopic composition using Raman spectroscopy and secondary ion mass spectroscopy (SIMS). These structures were found to contain macromolecular carbon signal and have a depleted 13C/12C carbon isotopic composition of – 35.4 ± 0.50‰ relative to the entombing carbonate matrix. These observations are consistent with a biological origin for the observed Frutexites structures.
Development of recommendation systems for software engineering: the CROSSMINER experience
Authors: Di Rocco Juri , Di Ruscio Davide , Di Sipio Claudio , Nguyen Phuong T. , Rubei Riccardo 
Published: May 2021

AbstractTo perform their daily tasks, developers intensively make use of existing resources by consulting open source software (OSS) repositories. Such platforms contain rich data sources, e.g., code snippets, documentations, and user discussions, that can be useful for supporting development activities. Over the last decades, several techniques and tools have been promoted to provide developers with innovative features, aiming to bring in improvements in terms of development effort, cost savings, and productivity. In the context of the EU H2020 CROSSMINER project, a set of recommendation systems has been conceived to assist software programmers in different phases of the development process. The systems provide developers with various artifacts, such as third-party libraries, documentation about how to use the APIs being adopted, or relevant API function calls. To develop such recommendations, various technical choices have been made to overcome issues related to several aspects including the lack of baselines, limited data availability, decisions about the performance measures, and evaluation approaches. This paper is an experience report to present the knowledge pertinent to the set of recommendation systems developed through the CROSSMINER project. We explain in detail the challenges we had to deal with, together with the related lessons learned when developing and evaluating these systems. Our aim is to provide the research community with concrete takeaway messages that are expected to be useful for those who want to develop or customize their own recommendation systems. The reported experiences can facilitate interesting discussions and research work, which in the end contribute to the advancement of recommendation systems applied to solve different issues in Software Engineering.
Genetic variability and trait association under thrips (Megalurothrips sjostedti Trybom) infestation in cowpea (Vigna unguiculata [L.] Walp.)
Authors: Toyinbo Johnson Oluwaseyi , Fatokun Christian , Boukar Ousmane , Fakorede Morakinyo Abiodun Bamidele 
Published: May 2021

AbstractFlower bud thrips is one of the most destructive insect pests of cowpea in sub-Saharan Africa. Information on genetic variability among cowpea germplasm and interrelationships among traits under thrips infestation would facilitate the development of resistant varieties. The objectives of the study were to assess genetic variability for thrips resistance, estimate heritability of yield and other traits and investigate inter-trait relationships under thrips infestation. One hundred and fifty-six cowpea lines, including one resistant and one susceptible check, were screened for resistance under natural infestation at two locations in Nigeria, in 2016. Test lines were scored for thrips damage weekly for three consecutive weeks, after removal of spreader plants, to obtain damage scores (DS) 1, 2 and 3 while data were collected on agronomic traits. The data were subjected to analysis of variance from which genetic components of the phenotypic variance were computed. Interrelationships among traits were determined using phenotypic and genotypic correlation, and sequential path analyses. Significant variability was observed among test lines. Lines TVu 6824 and TVNu 1307 were identified as possessing thrips resistance. DS3 had significant genetic and phenotypic correlations with DS1, DS2 and yield-related traits. Number of pods per peduncle, number of peduncles per plant and DS3 were identified as first-order traits. Heritability estimates ranged from 0.55 to 0.73. Genetic variability among the lines suggests the possibility of genetic control of thrips while number of pods per peduncle, number of peduncles per plant and DS3 would serve as useful selection criteria for thrips resistance.
Dugong foraging behavior on tropical intertidal seagrass meadows: the influence of climatic drivers and anthropogenic disturbance
Authors: Budiarsa Anugrah A. , De Iongh H. H. , Kustiawan Wawan , van Bodegom Peter M. 
Published: May 2021

AbstractForaging strategies of dugongs in tropical areas are not yet well understood, and that is particularly true for grazing of fast-growing pioneer seagrass meadows in the intertidal zones. In this study, we investigated the driving factors affecting the number of grazing tracks in intertidal seagrass meadows caused by small herds of dugongs in Balikpapan Bay, Indonesia. We investigated seven intertidal seagrass meadows for which the dynamics of seagrass biomass, the ratio aboveground to belowground biomass, and the number of grazing tracks were recorded and measured based on monthly intervals over a year. Seagrass features showed a significant relationship with wind speed, precipitation, desiccation time, the distance of the grazing sward to a residential area, and fishing activity based on multiple (generalized) linear models. While the intertidal seagrass meadows consisted of 5 species in total, only Halodule pinifolia patches were grazed. Dugong feeding tracks were found in four of the seven sites. The strong variation in the number of tracks throughout the year was significantly affected by seagrass biomass of seagrass, location and wind speed. Our results show how the interplay of site conditions related to both shelter (wind speed) and food availability (seagrass biomass) determines its suitability for dugongs.
Characterization of Gene Expression Signatures for the Identification of Cellular Heterogeneity in the Developing Mammary Gland
Authors: Henry Samantha , Trousdell Marygrace C. , Cyrill Samantha L. , Zhao Yixin , Feigman Mary. J. , Bouhuis Julia M. , Aylard Dominik A. , Siepel Adam , dos Santos Camila O. 
Published: May 2021

AbstractThe developing mammary gland depends on several transcription-dependent networks to define cellular identities and differentiation trajectories. Recent technological advancements that allow for single-cell profiling of gene expression have provided an initial picture into the epithelial cellular heterogeneity across the diverse stages of gland maturation. Still, a deeper dive into expanded molecular signatures would improve our understanding of the diversity of mammary epithelial and non-epithelial cellular populations across different tissue developmental stages, mouse strains and mammalian species. Here, we combined differential mammary gland fractionation approaches and transcriptional profiles obtained from FACS-isolated mammary cells to improve our definitions of mammary-resident, cellular identities at the single-cell level. Our approach yielded a series of expression signatures that illustrate the heterogeneity of mammary epithelial cells, specifically those of the luminal fate, and uncovered transcriptional changes to their lineage-defined, cellular states that are induced during gland development. Our analysis also provided molecular signatures that identified non-epithelial mammary cells, including adipocytes, fibroblasts and rare immune cells. Lastly, we extended our study to elucidate expression signatures of human, breast-resident cells, a strategy that allowed for the cross-species comparison of mammary epithelial identities. Collectively, our approach improved the existing signatures of normal mammary epithelial cells, as well as elucidated the diversity of non-epithelial cells in murine and human breast tissue. Our study provides a useful resource for future studies that use single-cell molecular profiling strategies to understand normal and malignant breast development.
Genetic Determinants of Paget’s Disease of Bone
Authors: Makaram Navnit S. , Ralston Stuart H. 
Published: May 2021

Abstract
Purpose of Review
To provide an overview of the role of genes and loci that predispose to Paget’s disease of bone and related disorders.

Recent Findings
Studies over the past ten years have seen major advances in knowledge on the role of genetic factors in Paget’s disease of bone (PDB). Genome wide association studies have identified six loci that predispose to the disease whereas family based studies have identified a further eight genes that cause PDB. This brings the total number of genes and loci implicated in PDB to fourteen. Emerging evidence has shown that a number of these genes also predispose to multisystem proteinopathy syndromes where PDB is accompanied by neurodegeneration and myopathy due to the accumulation of abnormal protein aggregates, emphasising the importance of defects in autophagy in the pathogenesis of PDB.

Summary
Genetic factors play a key role in the pathogenesis of PDB and the studies in this area have identified several genes previously not suspected to play a role in bone metabolism. Genetic testing coupled to targeted therapeutic intervention is being explored as a way of halting disease progression and improving outcome before irreversible skeletal damage has occurred.
Eurythenes atacamensis sp. nov. (Crustacea: Amphipoda) exhibits ontogenetic vertical stratification across abyssal and hadal depths in the Atacama Trench, eastern South Pacific Ocean
Authors: Weston Johanna N. J. , Espinosa-Leal Liliana , Wainwright Jennifer A. , Stewart Eva C. D. , González Carolina E. , Linley Thomas D. , Reid William D. K. , Hidalgo Pamela , Oliva Marcelo E. , Ulloa Osvaldo , Wenzhöfer Frank , Glud Ronnie N. , Escribano Rubén , Jamieson Alan J. 
Published: May 2021

AbstractEurythenes S.I. Smith in Scudder, 1882 (Crustacea: Amphipoda) are prevalent scavengers of the benthopelagic community from bathyal to hadal depths. While a well-studied genus, molecular systematic studies have uncovered cryptic speciation and multiple undescribed lineages. Here, we apply an integrative taxonomic approach and describe the tenth species, Eurythenes atacamensis sp. nov., based on specimens from the 2018 Atacamex and RV Sonne SO261 Expeditions to the southern sector of the Peru-Chile Trench, the Atacama Trench (24–⁠21°S). Eurythenes atacamensis sp. nov. is a large species, max. observed length 83.2 mm, possesses diagnostic features, including a short gnathopod 1 palm and a chelate gnathopod 2 palm, and a distinct genetic lineage based on a 16S rRNA and COI phylogeny. This species is a dominant bait-attending fauna with an extensive bathymetric range, spanning from 4974 to 8081 m. The RV Sonne SO261 specimens were recovered along a 10-station transect from abyssal to hadal depths and further examined for demographic and bathymetric-related patterns. Ontogenetic vertical stratification was evident across the trench axis, with only juveniles present at abyssal depths (4974–6025 m). Total length-depth analysis revealed that the size of females was unrelated to depth, whereas juveniles followed a sigmoidal relationship with a step-up in size at depths >7200 m. Thus, these bathymetric trends suggest that juveniles and females employ differing ecological strategies in subduction trench environments. This study highlights that even dominant and ecologically important species are still being discovered within the abyssal and hadal environments. Continued systematic expeditions will lead to an improved understanding of the eco-evolutionary drivers of speciation in the world’s largest ecosystem.
A Systematic Review of Healthcare Professionals’ Knowledge, Self-Efficacy and Attitudes Towards Working with Autistic People
Authors: Corden Kirsten , Brewer Rebecca , Cage Eilidh 
Published: May 2021

AbstractHealthcare professionals play a vital role in identifying and supporting autistic people. This study systematically reviewed empirical research examining healthcare professionals’ knowledge, self-efficacy and attitudes towards working with autistic people. Thirty-five studies were included. The included studies sampled a range of countries and professional backgrounds. A modified quality assessment tool found the quality of the included studies was moderately good. Narrative synthesis indicated that healthcare professionals report only moderate levels of autism knowledge and self-efficacy, and often lack training. Variation within and between countries and professional background was not explained by demographic factors. The reviewed evidence suggests health professionals’ limited knowledge and self-efficacy in working with autistic people is a challenge to the provision of healthcare for autistic individuals.
Multiple Hierarchical Heterojunction g-C3N4/LDH/Ag3PO4 With Enhanced Visible-Light Photocatalytic Activity for Cr(Vi) Reduction
Authors: Chen Chao-Rong , Zeng Hong-Yan , Xiong Jie , An De-Shun , Li Song 
Published: May 2021

AbstractSemiconductor photocatalysis has been regarded as one of the most promising methods for treatment of Cr(VI)-containing wastewater, but the high recombination rate of photogenerated carriers and photocorrosion have limited severely its practical application. The objective of the current study was to employ a layered double hydroxide (LDH) to mitigate these problems by designing and constructing a multiple heterojunction system of g-C3N4/LDH/Ag3PO4 (CNLDHAP) through a two-step hydrothermal route. The structures, morphologies, chemical states, and optical properties of the products were investigated systematically. The CNLDHAP composite showed superior photocatalytic activity for Cr(VI) reduction than that of the individual components under visible-light irradiation. The composite exhibited high photocatalytic reduction stability after five recycles. The enhanced photocatalytic performance may originate from the very efficient separation of photogenerated carriers of the multiple heterojunction system. Possible photocatalytic mechanisms for the reduction of Cr(VI) over the CNLDHAP composite photocatalyst are proposed.