bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombectomy for acute large vessel occlusion in posterior and anterior circulation: a single institutional retrospective observational study
Authors: Kuribara Tomoyoshi , Iihoshi Satoshi , Tsukagoshi Eisuke , Teranishi Akio , Kinoshita Yu , Sugasawa Shin , Kohyama Shinya , Takahashi Shinichi , Kurita Hiroki 
Published: September 2021

Abstract

Purpose
Thrombectomy has been the gold standard therapy for anterior circulation occlusion; however, studies regarding thrombectomy in posterior circulation are lacking. In this study, we compared the efficiency of thrombectomy for acute large vessel occlusion between the posterior and anterior circulation at a single institution.

Methods
We retrospectively analyzed consecutive patients who underwent thrombectomy for acute large vessel occlusion at our institution between August 2014 and April 2021. Differences in the clinical background, time course, and treatment technique and outcomes were evaluated between anterior and posterior circulation occlusions.

Results
Overall, 353 patients (225 men and 128 women) were included: 314 patients had anterior circulation occlusion and 39 patients had posterior circulation occlusion. Between the patients with anterior and posterior circulation occlusions, the National Institutes of Health Stroke Scale (NIHSS) score (16 [12–21] vs. 29 [19–34], respectively, p < 0.001), door-to-puncture time (65 [45–99] vs. 99 [51–121] min, respectively, p = 0.018), and mortality (22 [7%] vs. 8 [20.5%] patients, respectively, p = 0.010) were significantly different; however, favorable outcome was not significantly different.

Conclusion
Higher NIHSS score, delayed treatment, and higher mortality were observed in posterior circulation occlusion than in anterior circulation occlusion; successful reperfusion and favorable outcomes were similar between them. Similar favorable outcomes and reperfusion ratio to the anterior circulation might be achieved also in the posterior circulation; however, delayed treatment and the optimal first-pass strategy might need further improvement.
The importance of a lifeboat-median artery forearm flap in Goldenhar Syndrome
Authors: Jaźwiec Anna M. , Komorowska Timek Ewa D. 
Published: September 2021

AbstractWe present a case of a 32-year-old male with left-sided Goldenhar Syndrome and delta phalanx of the thumb, who was offered free tissue transfer from the forearm to address an intra-oral soft tissue deficiency. Despite the presence of appropriately developed right radial artery, used in previous facial reconstruction, the left radial artery occurred to be hypoplastic. He ultimately underwent free flap transfer based on the anomalous persistent left median artery. We suggest that in face of an unusual hand anatomy, flexible flap creation techniques that allow a lifeboat strategy of adjusting flap design should be considered preoperatively. Level of evidence: Level V, therapeutic study.
Aberrant patterns of PET response during treatment for DLBCL patients with MYC gene rearrangements
Authors: Eertink J. J. , Arens A. I. J. , Huijbregts J. E. , Celik F. , de Keizer B. , Stroobants S. , de Jong D. , Wiegers S. E. , Zwezerijnen G. J. C. , Burggraaff C. N. , Boellaard R. , de Vet H. C. W. , Hoekstra O. S. , Lugtenburg P. J. , Chamuleau M. E. D. , Zijlstra J. M. ,   the HOVON imaging workgroup
Published: September 2021

Abstract
Purpose
MYC gene rearrangements in diffuse large B-cell lymphoma (DLBCL) patients are associated with poor prognosis. Our aim was to compare patterns of 2[18F]fluoro-2-deoxy-D-glucose positron emission tomography computed tomography (PET/CT) response in MYC + and MYC- DLBCL patients.

Methods
Interim PET/CT (I-PET) and end of treatment PET/CT (EoT-PET) scans of 81 MYC + and 129 MYC- DLBCL patients from 2 HOVON trials were reviewed using the Deauville 5-point scale (DS). DS1-3 was regarded as negative and DS4-5 as positive. Standardized uptake values (SUV) and metabolic tumor volume (MTV) were quantified at baseline, I-PET, and EoT-PET. Negative (NPV) and positive predictive values (PPV) were calculated using 2-year overall survival.

Results
MYC + DLBCL patients had significantly more positive EoT-PET scans than MYC- patients (32.5 vs 15.7%, p = 0.004). I-PET positivity rates were comparable (28.8 vs 23.8%). In MYC + patients 23.2% of the I-PET negative patients converted to positive at EoT-PET, vs only 2% for the MYC- patients (p = 0.002). Nine (34.6%) MYC + DLBCL showed initially uninvolved localizations at EoT-PET, compared to one (5.3%) MYC- patient. A total of 80.8% of EoT-PET positive MYC + patients showed both increased lesional SUV and MTV compared to I-PET. In MYC- patients, 31.6% showed increased SUV and 42.1% showed increased MTV. NPV of I-PET and EoT-PET was high for both MYC subgroups (81.8–94.1%). PPV was highest at EoT-PET for MYC + patients (61.5%).

Conclusion
MYC + DLBCL patients demonstrate aberrant PET response patterns compared to MYC- patients with more frequent progression during treatment after I-PET negative assessment and new lesions at sites that were not initially involved.

Trial registration number and date of registration
HOVON-84: EudraCT: 2006–005,174-42, retrospectively registered 01–08-2008. HOVON-130: EudraCT: 2014–002,654-39, registered 26–01-2015
Predictors of Acceptance of Cosmetic Surgery: Instagram Images-Based Activities, Appearance Comparison and Body Dissatisfaction Among Women
Authors: Di Gesto Cristian , Nerini Amanda , Policardo Giulia Rosa , Matera Camilla 
Published: September 2021

Abstract
Background
This study aimed to test a model in which Instagram images-based activities related to self, friends, and celebrities were associated with acceptance of cosmetic surgery via Instagram appearance comparison and body dissatisfaction. We predicted that Instagram use for images-related activities involving celebrities and self (but not friends) was associated with acceptance of cosmetic surgery both directly and indirectly.

Methods
The study participants were 305 Italian women (mean age, 23 years). They completed a questionnaire containing the Instagram Image Activity Scale, the Instagram Appearance Comparison Scale, the Body Shape Questionnaire-14, the Acceptance of Cosmetic Surgery Scale. A path analysis was performed in which the Instagram images-based activities were posited as predictors of the Instagram appearance comparison, body dissatisfaction and acceptance of cosmetic surgery, respectively.

Results
We found that only image-based activities related to celebrities and self were significantly related to acceptance of cosmetic surgery, whereas friends’ Instagram-related activities were not significantly related to this criterion variable. Moreover, the indirect effect of both Instagram self- and celebrities-images activities on acceptance of cosmetic surgery through Instagram appearance comparison and body dissatisfaction was significant. Friends’ Instagram images-related activities were not associated with acceptance of cosmetic surgery.

Conclusions
Overall, these findings provide information about the role that activities carried out on Instagram, appearance comparison and body dissatisfaction, play on the acceptance of surgery for aesthetic reasons among women. The study highlighted the importance for surgeons to consider some psychological aspects and the influence of sociocultural factors on the interest for cosmetic surgery.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
The role of autologous stem cell transplantation (ASCT) in aggressive B-cell lymphomas: real-world data from a retrospective single-center analysis
Authors: Wullenkord Ramona , Berning Philipp , Niemann Anna-Lena , Wethmar Klaus , Bergmann Sarah , Lutz Mathias , Schliemann Christoph , Mesters Rolf , Keßler Torsten , Schmitz Norbert , Berdel Wolfgang E. , Lenz Georg , Stelljes Matthias 
Published: September 2021

Abstract
Patients with high-risk or relapsed aggressive B-cell lymphomas are characterized by poor prognosis. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) can induce durable remissions in these patients and is potentially curative. Two hundred forty-seven patients with aggressive B-cell lymphomas treated with high-dose chemotherapy and ASCT, either as consolidation after first-line therapy or after salvage therapy for relapsed disease, between 2002 and 2019 at the University Hospital Muenster, were analyzed. The median follow-up of surviving patients was 36 months (range 0–163). Progression-free survival (PFS) and overall survival (OS) after 3 years was 63% and 68%, respectively. After ASCT, 28% of all patients experienced a relapse. The cumulative incidence of non-relapse mortality at day 100 after ASCT was 4%. Multivariate analysis identified remission status at ASCT, age at ASCT, and the numbers of infused CD34+ cells as independent prognostic factors for both PFS and OS. Patients with mantle cell lymphoma (MCL) or primary CNS lymphoma (PCNSL) treated with ASCT in first-line had a superior OS and PFS when compared to patients treated with ASCT in relapsed disease. For patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL), early relapse (< 12 months) after first-line therapy showed a trend towards an inferior PFS and OS. Deaths after ASCT were predominantly caused by lymphoma relapse and/or progression (64%) or due to infections (23%). In conclusion, high-dose chemotherapy followed by ASCT in the era of novel targeted agents remains a feasible and effective approach for patients with high-risk or relapsed aggressive B-cell lymphomas. Remission status and age at ASCT, and the number of infused stem cells were of prognostic relevance.
Comparison of low-contrast detectability between uniform and anatomically realistic phantoms—influences on CT image quality assessment
Authors: Conzelmann Juliane , Genske Ulrich , Emig Arthur , Scheel Michael , Hamm Bernd , Jahnke Paul 
Published: September 2021

Abstract
Objectives
To evaluate the effects of anatomical phantom structure on task-based image quality assessment compared with a uniform phantom background.

Methods
Two neck phantom types of identical shape were investigated: a uniform type containing 10-mm lesions with 4, 9, 18, 30, and 38 HU contrast to the surrounding area and an anatomically realistic type containing lesions of the same size and location with 10, 18, 30, and 38 HU contrast. Phantom images were acquired at two dose levels (CTDIvol of 1.4 and 5.6 mGy) and reconstructed using filtered back projection (FBP) and adaptive iterative dose reduction 3D (AIDR 3D). Detection accuracy was evaluated by seven radiologists in a 4-alternative forced choice experiment.

Results
Anatomical phantom structure impaired lesion detection at all lesion contrasts (p < 0.01). Detectability in the anatomical phantom at 30 HU contrast was similar to 9 HU contrast in uniform images (91.1% vs. 89.5%). Detection accuracy decreased from 83.6% at 5.6 mGy to 55.4% at 1.4 mGy in uniform FBP images (p < 0.001), whereas AIDR 3D preserved detectability at 1.4 mGy (80.7% vs. 85% at 5.6 mGy, p = 0.375) and was superior to FBP (p < 0.001). In the assessment of anatomical images, superiority of AIDR 3D was not confirmed and dose reduction moderately affected detectability (74.6% vs. 68.2%, p = 0.027 for FBP and 81.1% vs. 73%, p = 0.018 for AIDR 3D).

Conclusions
A lesion contrast increase from 9 to 30 HU is necessary for similar detectability in anatomical and uniform neck phantom images. Anatomical phantom structure influences task-based assessment of iterative reconstruction and dose effects.

Key Points
• A lesion contrast increase from 9 to 30 HU is necessary for similar low-contrast detectability in anatomical and uniform neck phantom images.
• Phantom background structure influences task-based assessment of iterative reconstruction and dose effects.
• Transferability of CT assessment to clinical imaging can be expected to improve as the realism of the test environment increases.
On the axiomatic approach to sharing the revenues from broadcasting sports leagues
Authors: Bergantiños Gustavo , Moreno-Ternero Juan D. 
Published: September 2021

AbstractWe take the axiomatic approach to uncover the structure of the revenue-sharing problem from broadcasting sports leagues. We formalize two notions of impartiality, depending on the stance one takes with respect to the revenue generated in the games involving each pair of teams. We show that the resulting two axioms lead towards two broad categories of rules, when combined with additivity and some other basic axioms. We complement those results strengthening the impartiality notions to consider axioms of order preservation.
The discovery of the use of magnetic navigational information
Authors: Wiltschko Roswitha , Wiltschko Wolfgang 
Published: September 2021

AbstractThe magnetic field of the Earth provides animals with various kinds of information. Its use as a compass was discovered in the mid-1960s in birds, when it was first met with considerable skepticism, because it initially proved difficult to obtain evidence for magnetic sensitivity by conditioning experiments. Meanwhile, a magnetic compass was found to be widespread. It has now been demonstrated in members of all vertebrate classes, in mollusks and several arthropod species, in crustaceans as well as in insects. The use of the geomagnetic field as a ‘map’ for determining position, although already considered in the nineteenth century, was demonstrated by magnetically simulating displacements only after 2000, namely when animals, tested in the magnetic field of a distant site, responded as if they were physically displaced to that site and compensated for the displacement. Another use of the magnetic field is that as a ‘sign post’ or trigger: specific magnetic conditions elicit spontaneous responses that are helpful when animals reach the regions where these magnetic characteristics occur. Altogether, the geomagnetic field is a widely used valuable source of navigational information for mobile animals.
Impact on visual acuity and psychological outcomes of ranibizumab and subsequent treatment for diabetic macular oedema in Japan (MERCURY)
Authors: Sakamoto Taiji , Shimura Masahiko , Kitano Shigehiko , Ohji Masahito , Ogura Yuichiro , Yamashita Hidetoshi , Suzaki Makoto , Mori Kimie , Ohashi Yohei , Yap Poh Sin , Kaneko Takeumi , Ishibashi Tatsuro ,   for the MERCURY Study Group
Published: September 2021

Abstract
Purpose
The MERCURY study aimed to evaluate the effects on visual acuity and psychological symptoms, and safety, of ranibizumab and subsequent treatment in patients with diabetic macular oedema (DME) and impaired visual acuity (VA). We report data from the prespecified 12-month interim analysis.

Methods
This was a 24-month, phase 4, open-label, single-arm, prospective, observational study conducted at 20 specialised retinal centres in Japan. Participants were 209 patients with DME and impaired VA, not previously treated with either intravitreal or systemic anti-vascular endothelial growth factor (anti-VEGF) agents, who initiated ranibizumab 0.5 mg per investigator discretion. Following ranibizumab administration, patients were treated per routine clinical practice. Other treatments were allowed. The main outcome measure was the mean change in best-corrected VA (BCVA) in logarithmic minimum angle of resolution (logMAR) from baseline to month 12. An exploratory objective was to assess patients’ psychological status using the Hospital Anxiety and Depression Scale (HADS).

Results
The mean ± standard deviation BCVA at baseline was 0.43 ± 0.39 logMAR. The mean number of injections of ranibizumab and anti-VEGF agents from baseline to month 11 was 3.2 ± 2.0 and 3.6 ± 2.4, respectively. The BCVA change from baseline to 12 months was − 0.08 ± 0.34 logMAR (p = 0.011), showing a significant improvement; the HADS-anxiety score also decreased significantly (p = 0.001) and the depression score decreased numerically (p = 0.080).

Conclusion
MERCURY study data confirm the effectiveness of real-world treatment initiated with ranibizumab in Japanese patients with DME. In addition, treatment was able to positively influence anxiety via VA improvement.
The diagnostic value of Doppler ultrasonography after pediatric kidney transplantation
Authors: Franke Doris 
Published: September 2021

AbstractUltrasonography (US) plays a major diagnostic role in the pre- and post-transplant evaluation of recipient and donor. In most cases, US remains the only necessary imaging modality. After pediatric kidney transplantation, US can ensure immediate bedside diagnosis of vessel patency and possible postoperative non-vascular complications. Criteria for US diagnosis of kidney vessel thrombosis and stenosis in the transplant will be presented. Non-vascular complications after kidney transplantation include hydronephrosis, hematoma, lymphocele, and abscess. US can detect suggestive, but nevertheless non-specific, acute signs (sudden increase in volume and elevated resistive index), and chronic rejection, which therefore remains a histological diagnosis. US is of little or no help in detection of tubular necrosis or drug toxicity, but it can exclude other differential diagnoses. This educational review provides a practical and systematic approach to a multimodal US investigation of the kidney transplant. It includes a short overview on possible indications for contrast-enhanced ultrasonography (CEUS) in children after kidney transplantation.
Prototype generation in the string space via approximate median for data reduction in nearest neighbor classification
Authors: Castellanos Francisco J. , Valero-Mas Jose J. , Calvo-Zaragoza Jorge 
Published: September 2021

AbstractThe k-nearest neighbor (kNN) rule is one of the best-known distance-based classifiers, and is usually associated with high performance and versatility as it requires only the definition of a dissimilarity measure. Nevertheless, kNN is also coupled with low-efficiency levels since, for each new query, the algorithm must carry out an exhaustive search of the training data, and this drawback is much more relevant when considering complex structural representations, such as graphs, trees or strings, owing to the cost of the dissimilarity metrics. This issue has generally been tackled through the use of data reduction (DR) techniques, which reduce the size of the reference set, but the complexity of structural data has historically limited their application in the aforementioned scenarios. A DR algorithm denominated as reduction through homogeneous clusters (RHC) has recently been adapted to string representations but as obtaining the exact median value of a set of string data is known to be computationally difficult, its authors resorted to computing the set-median value. Under the premise that a more exact median value may be beneficial in this context, we, therefore, present a new adaptation of the RHC algorithm for string data, in which an approximate median computation is carried out. The results obtained show significant improvements when compared to those of the set-median version of the algorithm, in terms of both classification performance and reduction rates.
Aspartate or arginine? Validated redox state X-ray structures elucidate mechanistic subtleties of FeIV = O formation in bacterial dye-decolorizing peroxidases
Authors: Lučić Marina , Wilson Michael T. , Svistunenko Dimitri A. , Owen Robin L. , Hough Michael A. , Worrall Jonathan A. R. 
Published: September 2021

AbstractStructure determination of proteins and enzymes by X-ray crystallography remains the most widely used approach to complement functional and mechanistic studies. Capturing the structures of intact redox states in metalloenzymes is critical for assigning the chemistry carried out by the metal in the catalytic cycle. Unfortunately, X-rays interact with protein crystals to generate solvated photoelectrons that can reduce redox active metals and hence change the coordination geometry and the coupled protein structure. Approaches to mitigate such site-specific radiation damage continue to be developed, but nevertheless application of such approaches to metalloenzymes in combination with mechanistic studies are often overlooked. In this review, we summarize our recent structural and kinetic studies on a set of three heme peroxidases found in the bacterium Streptomyces lividans that each belong to the dye decolourizing peroxidase (DyP) superfamily. Kinetically, each of these DyPs has a distinct reactivity with hydrogen peroxide. Through a combination of low dose synchrotron X-ray crystallography and zero dose serial femtosecond X-ray crystallography using an X-ray free electron laser (XFEL), high-resolution structures with unambiguous redox state assignment of the ferric and ferryl (FeIV = O) heme species have been obtained. Experiments using stopped-flow kinetics, solvent-isotope exchange and site-directed mutagenesis with this set of redox state validated DyP structures have provided the first comprehensive kinetic and structural framework for how DyPs can modulate their distal heme pocket Asp/Arg dyad to use either the Asp or the Arg to facilitate proton transfer and rate enhancement of peroxide heterolysis.
Graphic abstract
Estimation of final standings in football competitions with a premature ending: the case of COVID-19
Authors: Gorgi P. , Koopman S. J. , Lit R. 
Published: September 2021

AbstractWe study an alternative approach to determine the final league table in football competitions with a premature ending. For several countries, a premature ending of the 2019/2020 football season has occurred due to the COVID-19 pandemic. We propose a model-based method as a possible alternative to the use of the incomplete standings to determine the final table. This method measures the performance of the teams in the matches of the season that have been played and predicts the remaining non-played matches through a paired-comparison model. The main advantage of the method compared to the incomplete standings is that it takes account of the bias in the performance measure due to the schedule of the matches in a season. Therefore, the resulting ranking of the teams based on our proposed method can be regarded as more fair in this respect. A forecasting study based on historical data of seven of the main European competitions is used to validate the method. The empirical results suggest that the model-based approach produces more accurate predictions of the true final standings than those based on the incomplete standings.
Prevalence and Antibiotic Resistance of Campylobacter spp. in Urban and Rural Black-Headed Gulls Chroicocephalus ridibundus
Authors: Indykiewicz Piotr , Andrzejewska Małgorzata , Minias Piotr , Śpica Dorota , Kowalski Jarosław 
Published: September 2021

AbstractWe investigate the role of black-headed gulls (Chroicocephalus ridibundus), an omnivorous species that is among the most likely wild bird candidates for transmission of zoonotic agents, as a potential reservoir ofCampylobacterspp. Colonies with different anthropogenic pressures were studied to examine differences in exposure to sources ofCampylobacterbetween rural and urban birds. We recordedCampylobacterspp. in 4.87% of adult black-headed gulls and 2.22% of their chicks after analysing 1036 cloacal swabs collected over two breeding seasons in three colonies in northern Poland.Campylobacter jejuniwas found most frequently (85.72%), andCampylobacter lariandCampylobacter coliwere much scarcer. Prevalence ofCampylobacterdid not differ significantly between black-headed gulls breeding in urban (4.27%) and rural (3.80%) habitats. Almost all isolates from chicks and adults were susceptible to azithromycin (97.62%) and erythromycin (95.24%), but fewer to tetracycline (50.00%) and ciprofloxacin (47.62%).Campylobacterprevalence was unrelated to the date of sampling. Our study indicates that black-headed gulls are carriers of resistant to antibioticsCampylobacterand they can contaminate natural waterbodies with their faeces, which poses a threat to human and farm animal health.