bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnografische Qualifikationsarbeiten im Setting Schule – das Spannungsfeld zwischen Forschungsethik, Datenschutz und Forschungspraxis
Authors: Knoche Veronika 
Published: October 2021

ZusammenfassungDas hier vorgestellte Dissertationsprojekt beschäftigt sich mit der Frage, wie Schulsozialarbeiter*innen ihr professionelles Handeln im beruflichen Alltag reflektieren. In der Vorbereitung der ethnografischen Feldphase zeigten sich forschungsethische, datenschutzrechtliche und forschungspraktische Fragestellungen. Der Kontext Schule als sensibles Forschungsfeld und die Rahmenbedingungen einer Qualifikationsarbeit bildeten die Grundlage der Fragestellungen im Hinblick auf die konkrete Umsetzung guter wissenschaftlicher Praxis. Die Beschreibung dieses Spannungsfeldes und der eingeschlagenen Lösungswege soll als Anregung dienen, um den Austausch über qualitative Sozialforschung und deren Rahmenbedingungen voranzutreiben.
From He-Cession to She-Stimulus? The labor market impact of fiscal policy across gender
Authors: Bonk Alica Ida , Simon Laure 
Published: October 2021

AbstractMen, especially those that are young and less educated, typically bear the brunt of recessions because of the stronger cyclicality of their employment and wages relative to women’s. We study the extent to which fiscal policy may offset or worsen these asymmetric effects across gender. Using micro-level data for the U.S. from the Current Population Survey, we find that the effects of fiscal policy shocks on labor market outcomes depend on the type of public expenditure. Women benefit most from increases in the government wage bill, while men are the main beneficiaries of higher investment spending. Our analysis further reveals that the fiscal component most efficient at closing gender gaps is least suitable for offsetting inequitable business cycle effects across other socioeconomic dimensions.
Zeptomole Imaging of Cytosolic MicroRNA Cancer Biomarkers with A Light-Controlled Nanoantenna
Authors: Song Yang , Cai Xiaoli , Ostermeyer Grayson , Ding Shichao , Du Dan , Lin Yuehe 
Published: October 2021

AbstractDetecting and quantifying intracellular microRNAs (miRNAs) are a critical step in resolving a cancer diagnostic and resolving the ensemble of gene products that orchestrate the living state of cells. However, the nanoprobe for detecting low abundance miRNAs in cell cytosol is restricted by either the “one-to-one” signal-trigger model or difficulty for cytosol delivery. To address these challenges, we designed a light-harvesting nanoantenna-based nanoprobe, which directs excitation energy to a single molecule to sensitively detect cytosolic miRNA. With light irradiation, the light-harvesting nanoantenna effectively disrupted lysosomal structures by generation of reactive oxygen species, substantially achieved cytosol delivery. The nanoantenna containing > 4000 donor dyes can efficiently transfer excitation energy to one or two acceptors with 99% efficiency, leading to unprecedented signal amplification and biosensing sensitivity. The designed nanoantenna can quantify cytosolic miR-210 at zeptomolar level. The fluorescence lifetime of the donor exhibited good relationship with miR-210 concentration in the range of 0.032 to 2.97 amol/ngRNA. The zeptomole sensitivity of nanoantenna provides accurate bioimaging of miR-210 both in multiple cell lines and in vivo assay, which creates a pathway for the creation of miRNA toolbox for quantitative epigenetics and personalized medicine.
Electrochemical Surface Restructuring of Phosphorus-Doped Carbon@MoP Electrocatalysts for Hydrogen Evolution
Authors: Jiang Huimin , Yan Liting , Zhang Shuo , Zhao Yanchao , Yang Xue , Wang Yameng , Shen Jianxing , Zhao Xuebo , Wang Lianzhou 
Published: October 2021

AbstractThe hydrogen evolution reaction (HER) through electrocatalysis is promising for the production of clean hydrogen fuel. However, designing the structure of catalysts, controlling their electronic properties, and manipulating their catalytic sites are a significant challenge in this field. Here, we propose an electrochemical surface restructuring strategy to design synergistically interactive phosphorus-doped carbon@MoP electrocatalysts for the HER. A simple electrochemical cycling method is developed to tune the thickness of the carbon layers that cover on MoP core, which significantly influences HER performance. Experimental investigations and theoretical calculations indicate that the inactive surface carbon layers can be removed through electrochemical cycling, leading to a close bond between the MoP and a few layers of coated graphene. The electrons donated by the MoP core enhance the adhesion and electronegativity of the carbon layers; the negatively charged carbon layers act as an active surface. The electrochemically induced optimization of the surface/interface electronic structures in the electrocatalysts significantly promotes the HER. Using this strategy endows the catalyst with excellent activity in terms of the HER in both acidic and alkaline environments (current density of 10 mA cm−2 at low overpotentials, of 68 mV in 0.5 M H2SO4 and 67 mV in 1.0 M KOH).
Differences in somatostatin receptor subtype expression in patients with acromegaly: new directions for targeted therapy?
Authors: Rass Lena , Rahvar Amir-Hossein , Matschke Jakob , Saeger Wolfgang , Renné Thomas , Aberle Jens , Flitsch Jörg , Rotermund Roman 
Published: October 2021

Abstract
Purpose
To analyze the expression of somatostatin receptor (SSTR)2a and 5 by immunohistochemistry (IHC) in surgically resected somatotrophic pituitary adenomas and to associate expression rates with tumor size and clinical, biochemical, and histological parameters and response to somatostatin analog (SA) therapy.

Methods
Forty-three microsurgically treated patients with histopathologically proven growth hormone (GH)–producing pituitary adenoma were included (WHO 2017). SSTR subtype expression was analyzed in adenoma tissues using monoclonal antibodies (Abcam, SSTR2a-UMB1, SSTR5-UMB4). Expression rates were classified as low (≤ 20% staining positivity), moderate (21–50%), and high (> 50%). Furthermore, biochemical parameters such as human growth hormone (hGH) and insulin-like growth factor-1 (IGF-1) levels were measured and clinical, biochemical, radiological, and histological data were evaluated.

Results
Of the 43 patients included in this study, 28 were female and 15 were male. The median age was 52 years (range 17–72 years). The median tumor size was 1.2 cm (range: 0.13–3.93 cm). All resected tumors showed positivity for somatotrophic hormone (STH). In all tissue samples, SSTR2a signal expression was detectable in immunohistochemistry, while only 39 samples were positive for SSTR5. Thirty-six samples had a high expression of SSTR2a, while three had a moderate and four a low SSTR2a signal. In comparison, SSTR5 signal was high in 26 out of 43 samples, while seven adenomas showed a moderate and six cases a low expression rate of SSTR5. The median IGF-1 was 714.2 µg/l and the median GH 19.6 mU/l (= 6.53 µg/l). The present study indicates that there is no significant relationship between the expression rates of receptor subtypes and the parameters we analyzed. However, our study revealed that smaller adenomas have a lower baseline GH level (p = 0.015),

Conclusion
IHC with monoclonal antibodies appears to be a suitable method to determine the expression rates of SSTR2a and 5 at protein levels, as it is not possible to draw conclusions regarding receptor subtypes solely on the basis of the parameters analyzed.
The Attack on Higher Education
Authors: Musto Ronald 
Published: October 2021

American higher education is under attack today as never before. A growing right-wing narrative portrays academia as corrupt, irrelevant, costly, and dangerous to both students and the nation. Budget cuts, attacks on liberal arts and humanities disciplines, faculty layoffs and retrenchments, technology displacements, corporatization, and campus closings have accelerated over the past decade. In this timely volume, Ronald Musto draws on historical precedent - Henry VIII's dissolution of British monasteries in the 1530s - for his study of the current threats to American higher education. He shows how a triad of forces - authority, separateness, and innovation - enabled monasteries to succeed, and then suddenly and unexpectedly to fail. Musto applies this analogy to contemporary academia. Despite higher education's vital centrality to American culture and economy, a powerful, anti-liberal narrative is severely damaging its reputation among parents, voters, and politicians. Musto offers a comprehensive account of this narrative from the mid-twentieth century to the present, as well as a new set of arguments to counter criticisms and rebuild the image of higher education.
Panprotopsychism Instantiated
Authors: GIBERMAN DANIEL 
Published: October 2021

AbstractThe problem of many-over-one asks how it can be thatmanyproperties are ever instantiated byoneobject. A putative solution might, for example, claim that the properties are appropriately bundled, or somehow tied to a bare particular. In this essay, the author argues that, surprisingly, an extant candidate solution to this problem is at the same time an independently developed candidate solution to the mind-body problem. Specifically, what is argued here to be the best version of the relata-specific bundle theory—the thesis that each instance of compresence has a special intrinsic nature in virtue of which it necessarily bundles its specific bundle-ees—is also a species of Russellian monism, labeled by David Chalmers as ‘constitutive Russellian panprotopsychism’. The upshot of this connection is significant for the metaphysics of the mind-body problem: a credible theory of property instantiation turns out to have a built-in account of how consciousness is grounded in certain (broadly) physical systems.
Legal Protection of the Marine Environment from Vessel-Source Oil Pollution: Progress and Challenges in Tanzania
Authors: Gamassa Pascal Kany Prud'ome 
Published: October 2021

AbstractThe United Republic of Tanzania, also called Tanzania, is a country composed of Mainland Tanzania and the islands of Zanzibar. Tanzania's domestic laws promote sustainable development of the marine environment; however, since the beginning of the 21st century, the country has been importing large quantities of oil, resulting in an increased risk of vessel-source oil pollution damage. Through a comparative analysis, this article examines the laws addressing this issue in Mainland Tanzania and Zanzibar, the progress that has been made in the legal environment and the challenges that remain, and it discusses possible solutions and improvements. The article reveals that weak implementation of domestic laws for marine environment conservation, a lack of harmonization between domestic laws regarding this issue, and weak domestication of relevant ratified international conventions are among the challenges currently hindering the sustainability of Tanzania's marine environment.
Rents instead of land. Credit and peasant indebtedness in late medieval Mediterranean Iberia: the kingdom of Valencia
Authors: Furió Antoni 
Published: October 2021

AbstractThe literature on the rural economy of the high and late Middle Ages has long established a close correlation between three significant features of the period: the spread of rural credit, the dynamism of the peasant land market and the expropriation of peasant land by the creditors, usually yeomen or urban landowners. There has even been talk for some countries (northern Italy) of a deliberate strategy of territorial conquest, insofar as the credit provided by urban lenders would aim at the expropriation of land from insolvent debtors. This article studies for the Mediterranean Spain of the late Middle Ages, and in particular for the old kingdom of Valencia, other objectives of rural credit and other alternatives to peasant expropriation in case of insolvency. Based on the rich archival holdings of the region, mainly notarial and judicial records, the article studies the dissemination of rural credit, the different modalities (short and long term), the motivations of creditors and debtors, the types of interest, the guarantors and the goods given as collateral for the loans, their confiscation in case of delay or insolvency. It concludes that, unlike elsewhere, the creditors, rather than in land, were interested in rents, that is, in the annuities paid to them by the debtors as interest on the loans obtained. The spread of long-term credit, therefore, not only did not threaten or subvert but also strengthened a system of land ownership, tenure and management based on regular rents extraction.
Nation-States, Empires, Wars, Hostilities
Authors: Ryan Cheyney 
Published: October 2021

AbstractA starting point for thinking about war and preparations for war is that today the average citizen in Western countries has absolutely no interest in fighting in a war him or herself. The best study of this phenomenon rightly notes that what might be called the “great refusal” of ordinary people to involve themselves in actual war making reflects what might be called the “great disillusionment” with war itself. However, this has not meant the end of war, or of preparations for war, but rather war's transformation from a “nationalized” to a “postnationalized” arrangement. For the United States, this has meant expansion into a new type of empire. As part of the symposium on Ned Dobos'sEthics, Security, and the War-Machine,this essay explores these developments and the challenges they pose.
Alfvén Waves Generated Through the Drift‐Bounce Resonant Instability in the Ring Current: A THEMIS Multi‐Spacecraft Case Study
Authors: Mager Olga V. 
Published: October 2021

AbstractThe satellites THA, THD, THE of THEMIS mission (Time History of Events and Macroscale Interactions during Substorms) have consistently recorded quasi‐monochromatic poloidal oscillations of the Pc4‐5 range in the nighttime magnetosphere. Wave activity was recorded after a substorm in the ring current region, between L‐shells 6 and 7.3. According to the data of the THA satellite, the fundamental and second harmonics of Alfvén wave were simultaneously recorded at frequencies of about 7 and 18 mHz, respectively. The satellites THD and THE recorded only the second harmonic and oscillating modulations of proton fluxes with energies of about 50 keV at the harmonic frequency. For this second harmonic wave, the azimuthal wave number was estimated using the phase delays of the oscillations in the proton fluxes with different gyrophases. It is shown that the wave was in drift‐bounce resonance with 46 keV protons and was generated through resonant instability caused by non‐equilibrium distribution of ring current protons with the significant earthward spatial gradient at the resonance energy.
Analytical Expressions of Radiocarbon Distribution in Transient State Unconfined Aquifers and Their Application to Determination of Past and Present Recharges of North Africa Aquifers
Authors: Chekireb Amine , Gonçalvès Julio , Hamelin Bruno , Deschamps Pierre , Séraphin Pierre 
Published: October 2021

AbstractIn this study, we developed two‐dimensional hydrodynamic age expressions for the free‐surface aquifer problem required for radiocarbon data interpretation in terms of recharge. Time‐varying recharge is accounted for in fully transient or pseudo‐steady state alternative analytical expressions applying to weakly or highly hydraulically reactive unconfined aquifers, respectively. These expressions extend the well‐known model proposed by Vogel in 1967 and represent a convenient alternative approach to the more complex numerical solution of a particle tracking problem considering climate variability. An application of the developed expressions was carried out to assess past (40 Kyr) and present recharge rates for the North Western Sahara Aquifer System (NWSAS) and the Djeffara plain (Tunisia‐Libya). Using the available 14C data at different outcrops, we obtained local recharge values ranging from 0.2 ± 1.7 to 4.5 ± 3.2 mm yr−1. Here, it is shown that using the standard purely steady‐state model for radiocarbon interpretation leads to a present recharge overestimation of up to 360%. A linear relation between the present recharge and the average annual rainfall was obtained and used to identify the regional distribution of the recharge and domain‐averaged values. Global values of 1.6 ± 2.3 mm yr−1 for the NWSAS and 3.5 ± 2.3 mm yr−1 for the Djeffara are in excellent agreement with the values obtained by hydrogeological models and derived using Satellite gravity data. The relation between recharge and rainfall obtained here can be used as a first‐order estimate for hydrogeological modeling or water management analysis for aquifers in the Saharan area.
Evaluating biometrics by using a hybrid MCDM model
Authors: Tsuei Hung-Jia , Shen Guiping , Tzeng Gwo-Hshiung 
Published: October 2021

AbstractBiometrics has been developing for decades in diverse industries, such as consumer electronics, internet of things, financial industry, etc. The purpose of this research is to build a decision-making model to evaluate and improve the performances of biometrics for administrators to design and make suitable biometric systems. This paper adopts a hybrid multiple criteria decision making (MCDM) model, comprising decision-making trial and evaluation laboratory (DEMATEL), and DEMATEL-based analytic network process (called DANP) to probe into the interrelationship and influential weights among criteria of biometrics. According to DEMATEL technique, the empirical results indicate that criteria of biometrics have self-effect relationships. The dimension of biometrics that administrators of biometrics should enhance first when improving the performances is usability. The criterion of universality with the highest influencing value to systematically affect all other evaluation factors is what administrators of biometrics should comprehensively consider. In the top three criteria for evaluation by DANP, biometric systems with the most influential weight is the criterion that can be improved to have higher recognition rates for increasing the performances of biometrics, followed by biometric conditions and permanence.
Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility
Authors: Kho Pik Fang , Wang Xuemin , Cuéllar-Partida Gabriel , Dörk Thilo , Goode Ellen L. , Lambrechts Diether , Scott Rodney J. , Spurdle Amanda B. , O’Mara Tracy A. , Glubb Dylan M. 
Published: October 2021

AbstractGenome-wide association studies (GWAS) have revealed sixteen risk loci for endoemtrial cancer but the identification of candidate susceptibility genes remains challenging. Here, we perform transcriptome-wide association study (TWAS) analyses using the largest endometrial cancer GWAS and gene expression from six relevant tissues, prioritizing eight candidate endometrial cancer susceptibility genes, one of which (EEFSEC) is located at a potentially novel endometrial cancer risk locus. We also show evidence of biologically relevant tissue-specific expression associations forCYP19A1(adipose),HEY2(ovary) andSKAP1(whole blood). A phenome-wide association study demonstrates associations of candidate susceptibility genes with anthropometric, cardiovascular, diabetes, bone health and sex hormone traits that are related to endometrial cancer risk factors. Lastly, analysis of TWAS data highlights candidate compounds for endometrial cancer repurposing. In summary, this study reveals endometrial cancer susceptibility genes, including those with evidence of tissue specificity, providing insights into endometrial cancer aetiology and avenues for therapeutic development.
Genotype-Phenotype Dissociation in Two Taiwanese Children with Molybdenum Cofactor Deficiency Caused by MOCS2 Mutation
Authors: Lee Hsiu-Fen , Hsu Chia-Chi , Chi Ching-Shiang , Tsai Chi-Ren 
Published: October 2021

Abstract
Background To describe the genotype-phenotype dissociation in two Taiwanese patients with molybdenum cofactor deficiency (MoCoD) caused by MOCS2 gene mutations.
Patient Description Patient 1 exhibited early-onset neurological symptoms soon after birth, followed by subsequent myoclonic seizures and movement disorder. The brain magnetic resonance imaging (MRI) showed diffuse brain injury with cystic encephalomalacia along with bilateral globus pallidi involvement, hypoplasia of corpus callosum, and cerebellar atrophy. Patient 2 had a mild phenotype with prominent movement disorder after intercurrent illness, and the brain MRI showed selective injury of the bilateral globus pallidi and the cerebellum. Both patients had markedly low levels of plasma uric acid and harbored the same MOCS2 homozygous c.16C > T mutation. Patient 1 showed chronic regression of developmental milestones and died of respiratory failure at the age of 8 years, whereas patient 2 demonstrated improvement in motor function.
Conclusion Genotype-phenotype dissociation could be noted in patients with MoCoD due to MOCS2 mutation. Patients with neonatal seizures, developmental delay, movement disorder, and motor regression after an illness, as well as focal or bilateral involvement of the globus pallidi on the neuroimages, should undergo biochemical testing of plasma uric acid. A pronounced plasma uric acid level is a good indicator of MoCoD. Early diagnosis can allow early provision of adequate genetic counseling.
Atomic-level defect modulation and characterization methods in 2D materials
Authors: Ngome Okello Odongo Francis , Yang Dong-Hwan , Chu Yu-Seong , Yang Sejung , Choi Si-Young 
Published: October 2021

Two-dimensional (2D) materials are attracting increasing research interest owing to their distinct tunable physical properties. Moreover, the ubiquitous defects in 2D materials offer an opportunity to tailor their electronic properties. Recently, atomic-level structural modification methods for 2D materials have been developed, further triggering the need for the precise control of defects. Following the ground-breaking advancements in the atomic-scale characterization of defects in 2D materials, valuable information on defect-driven electronic properties has been published. It is therefore important to present a review work on the recent research developments on atomic-level defect control and characterization of 2D materials. This Perspective highlights the type and role of atomic defects in 2D materials, as well as some current technologies for engineering such defects. In addition, we emphasize on atomic-level characterization methods with a focus on aberration-corrected transmission electron microscopy and deep learning as a powerful method for characterizing defects in 2D materials. Based on the two characterization techniques, we present the experimental results of laser-induced structurally modified MoTe2 and transition metal decorated h-BN. We believe that this work will provide fundamental knowledge for engineering and characterizing defects in 2D materials for the design of application-specific electronic devices.
Exploring deep neural networks via layer-peeled model: Minority collapse in imbalanced training
Authors: Fang Cong , He Hangfeng , Long Qi , Su Weijie J. 
Published: October 2021

Significance
The remarkable development of deep learning over the past decade relies heavily on sophisticated heuristics and tricks. To better exploit its potential in the coming decade, perhaps a rigorous framework for reasoning about deep learning is needed, which, however, is not easy to build due to the intricate details of neural networks. For near-term purposes, a practical alternative is to develop a mathematically tractable surrogate model, yet maintaining many characteristics of neural networks. This paper proposes a model of this kind that we term the Layer-Peeled Model. The effectiveness of this model is evidenced by, among others, its ability to reproduce a known empirical pattern and to predict a hitherto-unknown phenomenon when training deep-learning models on imbalanced datasets.