bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth
Authors: Takayama Ken-ichi , Honma Teruki , Suzuki Takashi , Kondoh Yasumitsu , Osada Hiroyuki , Suzuki Yutaka , Yoshida Minoru , Inoue Satoshi 
Published: May 2021

Abstract

RNA-binding protein PSF functions as an epigenetic modifier by interacting with long noncoding RNAs and the corepressor complex. PSF also promotes RNA splicing events to enhance oncogenic signals. In this study, we conducted an in vitro chemical array screen and identified multiple small molecules that interact with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability. Among these molecules and its derivatives was a promising molecule, No. 10–3 [7,8-dihydroxy-4-(4-methoxyphenyl)chromen-2-one], that was the most effective at blocking PSF RNA-binding ability and suppressing treatment-resistant prostate and breast cancer cell proliferation. Exposure to No. 10–3 inhibited PSF target gene expression at the mRNA level. Treatment with No. 10–3 reversed epigenetically repressed PSF downstream targets, such as cell-cycle inhibitors, at the transcriptional level. Chromatin immunoprecipitation sequencing in prostate cancer cells revealed that No. 10–3 enhances histone acetylation to induce expression of apoptosis as well as cell-cycle inhibitors. Furthermore, No. 10–3 exhibited antitumor efficacy in a hormone therapy–resistant prostate cancer xenograft mouse model, suppressing treatment-resistant tumor growth. Taken together, this study highlights the feasibility of targeting PSF-mediated epigenetic and RNA-splicing activities for the treatment of aggressive cancers.

Significance:
This study identifies small molecules that target PSF–RNA interactions and suppress hormone therapy–refractory cancer growth, suggesting the potential of targeting PSF-mediated gene regulation for cancer treatment.
Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling
Authors: Ma Angel P.Y. , Yeung Cherlie L.S. , Tey Sze Keong , Mao Xiaowen , Wong Samuel W.K. , Ng Tung Him , Ko Frankie C.F. , Kwong Ernest M.L. , Tang Alexander H.N. , Ng Irene Oi-Lin , Cai Shao Hang , Yun Jing Ping , Yam Judy W.P. 
Published: May 2021

Abstract

Lipid accumulation exacerbates tumor development, as it fuels the proliferative growth of cancer cells. The role of medium-chain acyl-CoA dehydrogenase (ACADM), an enzyme that catalyzes the first step of mitochondrial fatty acid oxidation, in tumor biology remains elusive. Therefore, investigating its mode of dysregulation can shed light on metabolic dependencies in cancer development. In hepatocellular carcinoma (HCC), ACADM was significantly underexpressed, correlating with several aggressive clinicopathologic features observed in patients. Functionally, suppression of ACADM promoted HCC cell motility with elevated triglyceride, phospholipid, and cellular lipid droplet levels, indicating the tumor suppressive ability of ACADM in HCC. Sterol regulatory element-binding protein-1 (SREBP1) was identified as a negative transcriptional regulator of ACADM. Subsequently, high levels of caveolin-1 (CAV1) were observed to inhibit fatty acid oxidation, which revealed its role in regulating lipid metabolism. CAV1 expression negatively correlated with ACADM and its upregulation enhanced nuclear accumulation of SREBP1, resulting in suppressed ACADM activity and contributing to increased HCC cell aggressiveness. Administration of an SREBP1 inhibitor in combination with sorafenib elicited a synergistic antitumor effect and significantly reduced HCC tumor growth in vivo. These findings indicate that deregulation of fatty acid oxidation mediated by the CAV1/SREBP1/ACADM axis results in HCC progression, which implicates targeting fatty acid metabolism to improve HCC treatment.

Significance:
This study identifies tumor suppressive effects of ACADM in hepatocellular carcinoma and suggests promotion of β-oxidation to diminish fatty acid availability to cancer cells could be used as a therapeutic strategy.
Perceptions of Shark Hazard Mitigation at Beaches Implementing Lethal and Nonlethal Shark Control Programs
Authors: Lucrezi Serena , Gennari Enrico 
Published: May 2021

Abstract
Beach-based recreation is an important ecosystem service. Its management relies on balancing human needs and the integrity of coastal ecosystems. Management, however, can be unbalanced in favor of the former, for example, through bather safety programs that are lethal to sharks and other marine species. The promotion of eco-friendlier shark control strategies is underpinned by an understanding of human engagement with shark hazard mitigation (SHM). This study used a questionnaire survey to assess beach visitors’ (N = 843) perceptions of SHM at locations implementing lethal and nonlethal shark control in South Africa. Perceptions were dependent on demography, water use, attitudes towards sharks, and local contexts. Elements requiring attention encompassed the role of fear in shaping perceptions, limited awareness of local SHM, misunderstanding of the ecological harm of some mitigation types, and personal responsibility in mitigating risks. Strategies to garner support for pro-shark beach-based recreation are discussed.
Context-specific cue use in the Eastern painted turtle (Chrysemys picta) and its effects on decision making
Authors: Roth Alexander D. , Krochmal Aaron R. , Roth Timothy C. 
Published: May 2021

Abstract
Many species consider both prior experiences and the context of current stimuli when making behavioural decisions. Herein, we explore the influence of prior experience and novel incoming stimuli on the decision-making in the Eastern painted turtle (Chrysemys picta). We used a free-choice Y-maze to assess the preferences of turtles wavelength and intensity of light. We then trained naïve turtles to associate one arm of a maze with a food reward, and then tested the relevance of light colour and intensity on the turtles’ decision-making regarding arm choice. Turtles avoided bright light, even when presented on the side of the maze with which they had learned to associate a food. When light intensities of both sides were the same — irrespective of intensity — turtles chose the side they had previously learned to associate with the food reward. C. picta in our study showed a weak attraction to blue light and a strong avoidance of yellow light, a response generally consistent with previous work in sea turtles. Future studies should examine the ecological and evolutionary relevance of these decisions in field-oriented tests.
The Dissemination of European Popular Print: Exploring Comparative Approaches
Authors: Salman Jeroen 
Published: May 2021

Abstract
This article discusses the prospects of a comparative approach within the field of the dissemination of European popular print. Currently, it is still hard to find studies that address distribution of popular print with a Europe-wide scope. After an introduction about the main concepts, models and approaches, the article discusses some topic related issues, questions, approaches and sources. Social and professional categorisations are explored, as well as the differences between urban and rural distribution, the impact of regional and international networks, the effects of trade regulations and the collaborative features of distribution practices. What became clear is that a wide-ranging study that includes all European countries is urgently needed but not within reach soon, due to a lack of fundamental research and assessible sources. We should therefore first start to collect data systematically and conduct a series of comparative case studies in which we explore important questions and approaches.
Narrative Fiction in Early Modern Europe
Authors: Schlusemann Rita , Wierzbicka-Trwoga Krystyna 
Published: May 2021

Abstract
The article presents a corpus of European fictional narratives, which were continuously printed in at least six European languages from the beginning of printing until the end of the eighteenth century. It analyses the denominations of the works in European literary histories in a comparative way in order to show the impact of the different national traditions in literary history, and provides a survey of the contemporary terms for the works used in European vernaculars. In early modern Europe there was an awareness of the congruence of these narratives and a similar choice of genre attributions in different European vernaculars whereas, as a consequence of the development of nationalism and national studies, the denomination of the genre and their studies has become much more tattered. We therefore propose to use the term ‘narrative fiction’ for the genre and the term ‘fictional narrative’ for the works themselves.
A Spatial Evaluation of Arctic Sea Ice and Regional Limitations in CMIP6 Historical Simulations
Authors: Watts Matthew , Maslowski Wieslaw , Lee Younjoo J. , Kinney Jaclyn Clement , Osinski Robert 
Published: May 2021

AbstractThe Arctic sea ice response to a warming climate is assessed in a subset of models participating in phase 6 of the Coupled Model Intercomparison Project (CMIP6), using several metrics in comparison with satellite observations and results from the Pan-Arctic Ice Ocean Modeling and Assimilation System and the Regional Arctic System Model. Our study examines the historical representation of sea ice extent, volume, and thickness using spatial analysis metrics, such as the integrated ice edge error, Brier score, and spatial probability score. We find that the CMIP6 multimodel mean captures the mean annual cycle and 1979–2014 sea ice trends remarkably well. However, individual models experience a wide range of uncertainty in the spatial distribution of sea ice when compared against satellite measurements and reanalysis data. Our metrics expose common and individual regional model biases, which sea ice temporal analyses alone do not capture. We identify large ice edge and ice thickness errors in Arctic subregions, implying possible model specific limitations in or lack of representation of some key physical processes. We postulate that many of them could be related to the oceanic forcing, especially in the marginal and shelf seas, where seasonal sea ice changes are not adequately simulated. We therefore conclude that an individual model’s ability to represent the observed/reanalysis spatial distribution still remains a challenge. We propose the spatial analysis metrics as useful tools to diagnose model limitations, narrow down possible processes affecting them, and guide future model improvements critical to the representation and projections of Arctic climate change.
Auricular Perichondrium Graft for Septal Perforation Repair
Authors: Bansberg Stephen F. , Taylor Cullen M. , Neel Gregory S. 
Published: May 2021

Objectives: Procedures which utilize bilateral mucosal flaps with an interposition graft are frequently used when attempting closure of a septal perforation. Concurrent surgical management of the nasal valve or an aesthetic deformity may be indicated. The objective of this study is to report our experience using auricular perichondrium for the interposition graft when auricular cartilage is harvested for structural or aesthetic graft material. Methods: A retrospective medical record review was performed for septal perforation repairs performed at Mayo Clinic in Arizona from January 2010 through January 2020. Patients identified for this study underwent a procedure utilizing bilateral nasal mucosal flaps with an auricular perichondrium interposition graft. Results: Forty-four patients (31 females) with a mean age of 53.3 years met study criteria. The most common presenting symptoms were nasal obstruction, crusting, and epistaxis. Prior septal surgery was the most common perforation etiology (45.5%). Mean perforation length was 11.8 (range, 3-26) mm and height, 9.1 (range, 2-16) mm. Auricular cartilage was harvested for nasal valve surgery in 43 patients. Complete perforation closure was noted in 95.3% (41/43) of patients with a minimum post-operative follow-up of 3 (mean, 20.4) months. Four patients underwent revision surgery for persistent postoperative nasal obstruction. Conclusion: The ear can provide both cartilage and perichondrium for use in septal perforation surgery. Our study demonstrates the successful use of auricular perichondrium as the interposition graft for a perforation closure procedure utilizing bilateral nasal mucosal flaps.
Stapes Surgery in Far-Advanced Otosclerosis
Authors: Luca Moscillo , Massimilla Eva Aurora , Americo Mastella , Michele Nunziata , Donadio Anna , Gaetano Motta 
Published: May 2021

Introduction: Surgical treatment of patients with far-advanced otosclerosis (FAO) has not yet been standardized. Patients with FAO are the candidates for stapes surgery or cochlear implant (CI). Although many surgeons consider stapes surgery as the first choice, other authors prefer CI because of the excellent hearing results. Objective: The authors discuss their experience in the treatment of patients with FAO, potentially candidates for CI, who underwent stapedotomy. Materials and Methods: Eleven adult patients with FAO underwent stapedotomy from 2006 to 2016. Pure-tone average (PTA) between 0.5-1-2-3 kHz and speech perception test with hearing aids were determined before and after stapedotomy. Results: The results show a statistically significant improvement in air condition threshold (PTA) and satisfactory results with regard to speech recognition in 9 (81.8%) cases. Postoperative results are not influenced by the type of stapedotomy prosthesis employed and do not change during follow-up (3 years). Conclusions: The authors suggest first performing stapes surgery in patients with FAO and reserving CI in case of failure.
Cost-Effectiveness of Hearing Screening in Older Adults: A Scoping Review
Authors: Hsu Amber K. , Bassett Sarah M. , O’Dwyer Linda C. , McHugh Megan , Heinemann Allen W. , Jordan Neil , Dhar Sumitrajit 
Published: May 2021

Objectives: Age is the most common predictor of hearing loss; however, many older adults are not screened. Hearing screening could improve healthcare access, participation, and outcomes. Establishing whether hearing screening in older adults is cost-effective could improve the availability and utilization of screening. Methods: We searched nine databases in January 2020. Studies with populations aged 50+ and provided data on the cost-effectiveness of hearing screening were included in the review. Results: Five studies met the inclusion criteria and all found hearing screening programs to be cost-effective compared to no hearing screening, regardless of screening method (i.e., instrument or strategy). The maximum number of repeated screenings, coupled with younger ages, was most cost-effective. Discussion: This review suggests that hearing screening in older adults is cost-effective, however, the evidence is limited. There is pressing need for research focused on economic impacts of hearing healthcare in older adults to inform research, policy and practice.
Where is the Breughel Village? Community and the radical tradition
Authors: Kaviraj Sudipta 
Published: May 2021

This article notes the revival of interest in the idea of community in recent debates in political theory. It argues that one of the clearest presentations of the problem was in Hegel, taken up by the radical tradition from Marx. It analyses the further elaboration of the structure of the problem in Marx but argues that there is a baffling difficulty because the answer to the problem of community comes in the form of the state – an apparatus least likely to create communal connection among alienated individuals. Next, Toennies’s classic analysis is taken up for scrutiny. Finally, it suggests that this large question can be broken up into more manageable smaller ones if we think about the artistic representations of the community idyll.
Critical perspectives on implementation of evidence-based practice in occupational therapy – Exemplified by Lifestyle Redesign® in a Danish context
Authors: Glasdam Stinne , Oute Jeppe , Stjernswärd Sigrid 
Published: May 2021

Introduction Evidence-based practice is an increasing demand in occupational therapy (OT), although multiple barriers can hinder the translation of research knowledge into practice. The article illuminates the transformation of results from a randomised controlled trial into a practice development project with future practice implementation in mind. Method A case study was carried out, consisting of a comparison of the US randomised controlled trials (RCTs) Lifestyle Redesign® and the derived Danish practice development project. Results The study showed how results from RCTs of Lifestyle Redesign® were transformed into a practice development project with intentions to implement the programme in a Danish context. The modifications of the US RCT into a practice development project in Denmark compromised the study’s scientific execution. The practice development project was used to legitimise the intervention within OT locally by testing an evidence-based intervention, without using associated scientific tools and without considering barriers and facilitators for implementing the project in clinical practice. Conclusion Research design compromises in practice development projects may have implications for the internal and external dynamics of professionalisation processes regarding OT and the recognition of OT as a scientific discipline and an autonomous profession, nationally and internationally.
Assessment of COVID-19 control strategies in a steel industry using a SWOT matrix
Authors: Hesami Arani Mohsen , Moslemzadeh Mehrdad , Fallahzadeh Omid , khorvash Hamidreza , Dakhilpour Mahmoud , Mohammadzadeh Mahdiyeh 
Published: May 2021

According to the health regulations, industrial environments due to the gathering of people are considered as one of the highest-risk places during the COVID-19 pandemic. Thus, planning with regard to health concerns can decisively help in infection control and continuity of businesses during the pandemic. The aim of this study was to evaluate the COVID-19 control management measures in the Sepid-farab Kavir Steel Complex (SKS complex) located in Isfahan province (Iran) using strengths, weaknesses, opportunities, and threats (SWOT) matrix. After a literature review and field surveys, all weak, strong, threatening, and opportunity points were collected and were listed using the internal factor evaluation (IFE) and external factor evaluation (EFE) matrices and then were prioritized and weighted. Next, given the sum of scores of IFE and EFE, the SWOT matrix was constructed, the disease prevention and control strategies in the complex was determined, and finally, experts proposed corrective measures to improve the current situation. The results of the IFE matrix (IFE) analysis showed that in terms of corona control, there are more weaknesses than strengths within the company (the score of this matrix was 201.12). Also the score of 165 on the EFE matrix indicated that external threats were predominant, compared to external opportunities of company. SWOT analysis showed that despite some external problems and challenges, the existence of a favorable internal decision-making system had an important role in developing appropriate health strategies and implementing effective prevention measures in SKS complex against the COVID-19.
The Online Attention to Cleft Lip and Palate Research: An Altmetric Analysis
Authors: Badran Serene , Hassona Yazan 
Published: May 2021

Objectives: To identify research articles related to cleft lip and/or cleft palate (CL/P) that generated the highest online attention. Methods: Altmetric Explorer was used to identify the 100 articles with the highest Altmetric Attention Score (AAS). Descriptive and correlation statistics were performed to study the characteristics of these articles in relation to their publication data, research type and domain, number of Mendeley readers, and dimensions citations. Citation counts were extracted from Scopus and Google Scholar. Results: The median AAS for the top 100 outputs was 22 (range from 12 to 458). The outputs were mostly discussed on Twitter (median = 8; range = 0-131). Topics discussing treatment and care for patients with CL/P accounted for 38% of the articles with the highest AAS followed by etiology and risk factors (32%). The majority of articles originated from the USA (46%) followed by Europe (16%) and the United Kingdom (15%). No significant differences were observed in AAS among different study designs, topic domains, journals’ ranking and impact factor, and the number of citations in Scopus and Google Scholar. Conclusions: Researchers should consider use of social platforms to disseminate their work among scholars and nonscholars. Altmetrics can be combined with traditional metrics for a more comprehensive assessment of research impact.
Preliminary Outcomes of Viabahn Balloon-Expandable Endoprosthesis as Bridging Stent in Renal Arteries During Fenestrated Endovascular Aortic Repair
Authors: Mezzetto Luca , Mastrorilli Davide , Leone Nicola , Gennai Stefano , Silingardi Roberto , Veraldi Gian Franco , Piazza Michele , Squizzato Francesco , Antonello Michele 
Published: May 2021

Purpose: To report preliminary outcomes of Viabahn Balloon-Expandable Endoprosthesis (VBX) stent-graft as bridging stent for renal arteries in fenestrated endovascular aneurysm repair (FEVAR). Materials and Methods: Between 2018 and 2019, patients undergoing FEVAR at 3 referral Italian university hospitals were prospectively collected. During the study period, VBX was the first-line choice as bridging stent for renal arteries. Procedural and anatomical data were analyzed, including renal artery (RA) configuration. A dedicated software (3Mensio, Vascular Imaging, Bilthoeven, The Netherlands) was used and RA anatomy classified as follow: upward-oriented in case of any angle >30° above the horizontal or transverse axis perpendicular to the aortic axis, downward-oriented if there was an angle >30° measured below the transverse axis and downward + upward in case of an angle <30° associated with a renal artery angulation >90°. Primary endpoints were technical success, defined as complete deployment of the fenestrated endograft without target vessel (TV) loss, limb stenosis or occlusion and type I or III endoleak, and freedom from target artery instability (TAI), defined by target vessel-related death, occlusion, rupture or reintervention for stenosis, endoleak or disconnection. Secondary endpoints were target artery patency rate and freedom from reinterventions. Results: A total of 26 elective FEVAR for juxta/pararenal aneurysm (20), thoracoabdominal type II (3) and type IV (3) were included. Fifty-one RA were planned for revascularization. Of these, 32 were downward, 10 horizontal, 6 upward, 4 were downward + upward. Technical success was achieved in 88.5% (23/26) of patients and 94.2% (48/51) of the TVs. One occlusion (2.1%) occurred within 30 days in a patient with previous endovascular aortic repair and suprarenal fixation. During follow-up (median 10 months), there was 1 type IC endoleak after 6 months (2.1%) in a patient with upward plus downward arterial orientation. Freedom from TAI was 96.1% (CI = 0.89 to 1.04) at first month and 92.3% (CI = 0.82 to 1.03) at 6 months. No aneurysm-related mortality and renal insufficiency occurred during follow-up. Conclusion: The use of VBX as bridging stent of RA in FEVAR is safe and feasible. Previous EVAR and tortuosity of RA may be a challenging on target vessel fate.