bluuebunny/crossref_metadata_2025_split huggingface dataset:
Android based information system for eco-site destination
Authors: Fardiansyah  , Ihsan MA , Junanda SF , Asmaidi  , Rahmanizar C , Rusnanda R , Kartawijaya M , Candra R A 
Published: February 2021

Abstract
With the rapid development of information and communication technology, the internet has become an essential medium for obtaining or exchanging information without the obstruction of distance, time, and place. The purpose of developing this application is to design the nearest Tourism Location Search Application in South Aceh district based on Android. This application was created using Android Studio. This application provides information about existing tourist objects from location information, facilities, and guidance to reach the location using the Maps method. Users of the application can choose attractions based on categories and the system will provide a guide to the tourist sites that can be visited.
Design of simple clove harvesters
Authors: ‘Audahl S , Setiawan H , Putriawati F , Anhar  
Published: February 2021

Abstract
Clove plucking techniques can be done by climbing stairs and trees. Harvesting by climbing trees should not be done, Can be used ladder or pole made of bamboo while paying attention to the position of the ladder on the clove tree to avoid breaking the branching clove and not damage the surrounding leaves at the time of picking, researchers also saw cloves when they were out of reach of the hands then the clove farmers just throw it away clove should be able to be useful and increase income. Researchers tried to make a simple clove harvester design tool with the aim to facilitate the clove picking process. The results of this tool can be used on a tree height of 4 meters that can be used directly without using a ladder and can be used as a clove picker that is not reached by the hands of farmers so it is not wasted..
A Self-defined Index for Hygrothermal Performance-Oriented Development of Bamboo and Its Test Method
Authors: Huang Zujian , Sun Yimin 
Published: February 2021

AbstractIn the manufacturing process of the mechanical performance-oriented bamboo products, the bulk density is often used as an important control index since it has significant correlation with the mechanical properties. However, the development of bamboo for building envelope is supposed to be hygrothermal performance-oriented, which may require a different control index. In this study, 6 typical bamboo products are selected as the research objects. Based on the material parameter requirements of the building envelope coupled heat and moisture process model, 6 test items for hygrothermal properties and 2 test items for basic properties, including the dry bulk density (ρd) and a self-defined ‘open porosity of liquid water (Φl)’, are carried out. Correlation analyses between the tested hygrothermal properties and the basic properties show that, macroscopically both moisture and heat transport properties show stronger correlation withΦlthan that withρd. Taking the correlation coefficient (r) and the statistical significance (sig) as indicators, the correlations between the hygrothermal properties andΦlare, respectively, 107.23%–140.00% and 1.44%–11.94% of that between the hygrothermal properties andρd. The phenomenon proves thatΦlis potential to be a better control index for the development of hygrothermal performance-oriented bamboo. Based on this, a method including 6 operation steps to test theΦlis introduced.
Thermal Comfort in the Modern Movement – Consequences of Constructive Definition on the Summer Behaviour of a Housing Building in Porto, Portugal
Authors: Silva I , Mendonça P , Maia C 
Published: February 2021

Abstract
The knowledge of the properties of construction materials, as well as the way they are organized in the construction systems, namely those of the facades, are essential to understand the functional performance of buildings, namely their thermal comfort. This article presents a research oriented towards the constructive characterization of the facades of a multifamily building and the consequences for its thermal comfort in summer. The building here analysed is Edifício Lino, built between 1951 and 1954 in Porto, designed by the architects Arménio Losa and Cassiano Barbosa, prominent figures in the architecture of the modern movement in Portugal. The importance of studying buildings at this time is related to the need to define strategies for use, maintenance and possible intervention in the existing heritage in order to respond to the contemporary expectations of habitability of these works of the Modern Movement, often forgotten due to the temporal proximity. From the study carried out, it can be concluded that thermal comfort emerges as a central concern of the reference architects of this time, who considered this issue an inexorable architectural quality.
Sustainable Urban Pavement for Cities Affected by El Niño using Porous Concrete
Authors: Aguirre B , Anchiraico M , Rodríguez J , García F 
Published: February 2021

Abstract
The El Niño phenomenon is caused by the change in atmospheric pressures, which produce the accumulation of hot surface waters on the eastern flank of the Pacific Ocean; causing intense rainfall that runs over the surface affecting the urban drainage of the city due to the lack of a permeable pavement; porous concrete allows infiltration of surface water runoff through its pores. The present investigation evaluates porous concrete in the range of w/c relationships of 0.30 and 0.32; the results indicate that the compressive strength, flexural strength and permeability coefficient increase; and that the surface runoff, cost, water footprint and carbon footprint are lower than conventional concrete.
The Role of the Laser Safety Officer and Laser Safety Programs in Clinical Practice
Authors: Wamsley Christine E , Hoopman John , Kenkel Jeffrey M 
Published: February 2021

Abstract
Recent advancements in laser technology have led to its expanded utilization in smaller clinical settings and medical spas, particularly for facial rejuvenation and the treatment of other aesthetic concerns. Despite the increasing popularity of this technology, discussion of laser safety programs has remained limited, mostly to operating rooms at larger clinical institutions. Although smaller facilities do not operate at the same capacity as a large hospital or medical center, the requirements for utilizing a laser are no less stringent. Employers must comply with local and federal regulations, the Occupational Safety and Health Administration (OSHA) General Duty Clause, American National Standards Institute (ANSI) standards, and professional recommended practices applicable to their business. Although the laser safety officer (LSO) is often a full-time position within larger facilities, smaller clinical settings and medical spas may be limited in staff number. It is important, therefore, that clinical practices establish laser policies and procedures with consideration of their individual needs and capabilities. In this paper, we will define a laser safety program, highlight basic requirements needed to establish this program, and outline the specific responsibilities of the LSO. To ensure that safe laser practices are being conducted at the healthcare facility, it is imperative that small business owners are aware of these regulations and standards in place for the operation of laser systems.
Long noncoding RNA MNX1-AS1 functions as a competing endogenous RNA to regulate epithelial-mesenchymal transition by sponging MiR-744-5p in colorectal cancer
Authors: Huang Shiping , Sun Yueming 
Published: February 2021

ABSTRACTColorectal cancer (CRC) is the fourth most deadly cancer globally. Long noncoding RNA MNX1-AS1 has been proven to play a regulatory role in various human cancers. The present research aimed to explore the MNX1-AS1 function in CRC and the corresponding mechanism. A series of experiments were conducted to detect the effects of MNX1-AS1 and miR-744-5p on the biological function of CRC cells, including quantitative reverse transcription–polymerase chain reaction, CCK-8, transwell, wound healing assay, Western blot, and dual-luciferase report assay. MNX1-AS1 was elevated in CRC tissues and cell lines. Si-MNX1-AS1 inhibited cell viability, invasion, migration, and the protein expressions of N-cadherin and Vimentin but promoted the protein expression of E-cadherin. MiR-744-5p bound to MNX1-AS1. MiR-744-5p inhibitor had the opposite effect of si-MNX1-AS1. Cotransfection of miR-744-5p inhibitor and si-MNX1-AS1 recovered the effects mentioned above. In conclusion, MNX1-AS1/miR-744-5p axis plays a pivotal role in the viability, invasion, migration, and epithelial-mesenchymal transition of colorectal cancer cells.
Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models
Authors: Wang Yuanyuan , Guo Shanqi , Jia Yingjie , Yu Xiaoyu , Mou Ruiyu , Li Xiaojiang 
Published: February 2021

ABSTRACT
Prostate cancer (PCa) is one of the important factors of cancer deaths especially in the western countries. Hispidulin (4′,5,7-trihydroxy-6-methoxyflavone) is a phenolic flavonoid compound proved to possess anticancer properties, but its effects on PCa are left to be released. The aims of this study were to investigate the effects and the relative mechanisms of Hispidulin on PCa development. Hispidulin administration inhibited proliferation, invasion, and migration, while accelerated apoptosis in Du145 and VCaP cells, which was accompanied by PPARγ activation and autophagy enhancement. The beneficial effects of Hispidulin could be diminished by PPARγ inhibition. Besides, Hispidulin administration suppressed PCa tumorigenicity in Xenograft models, indicating the anticancer properties in vivo. Therefore, our work revealed that the anticancer properties of Hispidulin might be conferred by its activation on PPARγ and autophagy.
Three main short-chain fatty acids inhibit the activation of THP-1 cells byMycoplasma pneumoniae
Authors: Wen Xia , Xiaoyue Dai , Longkun Ding , Yue Xi , Man Yan , Min Zhang , Liang Wu , Chengxue Yi , Huaxi Xu 
Published: February 2021

ABSTRACTThe overactivation of macrophages causes chronic inflammatory diseases. Short-chain fatty acids (SCFAs), potential drugs for clinical treatment, are modulators of macrophage inflammatory reaction. Therefore, the modulation of macrophage-mediated cell activity is expected to become a new therapeutic strategy for inflammatory diseases caused by Mycoplasma pneumoniae. In this study, 2 kinds of SCFAs (propionate and butyrate) were found to have anti-inflammatory effects in M. pneumoniae-stimulated THP-1 cells inflammatory. They inhibited the expressions of IL-4, IL-6, ROS, and NLRP3 inflammasome, while enhancing the expressions of IL-10 and IFN-γ. Our study revealed these 2 agents to repress transcriptional activities of NF-κB, which are important modulators of inflammation. Meanwhile, SCFAs can significantly enhance the autophagy induced by M. pneumoniae. Considering that SCFAs have few side effects, they might be the promising adjuvant therapy for the prevention and/or treatment of various inflammatory diseases.
A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900
Authors: Ueoka Reiko , Hashimoto Junko , Kozone Ikuko , Hashimoto Takuya , Kudo Kei , Kagaya Noritaka , Suenaga Hikaru , Ikeda Haruo , Shin-ya Kazuo 
Published: February 2021

ABSTRACT
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by the biotransformation of the synthetic intermediate before. Their structures were determined by the spectroscopic data and the chemical derivatization. 12-Ketomethymycin showed a weak cytotoxicity against SKOV-3 and Jurkat cells, although its N-oxide analog did not show any activity. Both showed no antibacterial activities against Escherichia coli and Micrococcus luteus.
No sex differences in learning in wild bumblebees
Authors: Muth Felicity , Tripodi Amber D , Bonilla Rene , Strange James P , Leonard Anne S 
Published: February 2021

Abstract
Females and males often face different sources of selection, resulting in dimorphism in morphological, physiological, and even cognitive traits. Sex differences are often studied in respect to spatial cognition, yet the different ecological roles of males and females might shape cognition in multiple ways. For example, in dietary generalist bumblebees (Bombus), the ability to learn associations is critical to female workers, who face informationally rich foraging scenarios as they collect nectar and pollen from thousands of flowers over a period of weeks to months to feed the colony. While male bumblebees likely need to learn associations as well, they only forage for themselves while searching for potential mates. It is thus less clear whether foraging males would benefit from the same associative learning performance as foraging females. In this system, as in others, cognitive performance is typically studied in lab-reared animals under captive conditions, which may not be representative of patterns in the wild. In the first test of sex and species differences in cognition using wild bumblebees, we compared the performance of Bombus vancouverensis nearcticus (formerly bifarius) and Bombus vosnesenskii of both sexes on an associative learning task at Sierra Nevada (CA) field sites. Across both species, we found that males and females did not differ in their ability to learn, although males were slower to respond to the sucrose reward. These results offer the first evidence from natural populations that male bumblebees may be equally as able to learn associations as females, supporting findings from captive colonies of commercial bees. The observed interspecific variation in learning ability opens the door to using the Bombus system to test hypotheses about comparative cognition.
The Legitimacy of Change: Adopting/Adapting, Implementing and Sustaining Reforms within Community Corrections Agencies
Authors: Rudes Danielle S , Portillo Shannon , Taxman Faye S 
Published: February 2021

AbstractMany criminal justice institutions implement evidence-based reforms. While most scholars are aware of implementation challenges, we still know relatively little about sustainability. Using longitudinal data from criminal legal staff implementing an evidence-based reform, this paper considers: What happens during the implementation of an organizational reform that affects continued use of these reforms? Guided by an organizational change framework, findings suggest sustainability aligns with key organizational goals including legitimacy, efficiency and effectiveness. While all sites saw the reformed practices as legitimate enough to initially consider adoption, two sites never adopted, four sites toyed with reform, and two sites continued to use the reform after the study was over. This paper explores sustainability and identifies legitimacy as an important factor that affects the routinization of new practices. Transformation of organizational change initiatives into routine practices should consider efforts to build legitimacy in lieu of primarily rationalizing on the values of efficiency and effectiveness.
Social Service Worker Experiences with Direct and Indirect Violence When Engaged with Service Users
Authors: Shier Micheal L , Turpin Aaron , Nicholas David B , Graham John R 
Published: February 2021

AbstractSocial service workers’ experiences of violence from service users (client-engaged violence) in social service workplaces are serious and pervasive issues that demand responsive and effective organisational interventions. However, organisational factors and characteristics that have an effect on worker experiences of client-engaged violence are poorly defined. This study utilised a quantitative design to identify and measure aspects of the organisation that prevent client-engaged violence and support workers in building healthy and safe workplaces. Participants (n = 1,574) from various publicly administered social services departments were surveyed to assess the effect of ‘workload’ (workload quality); ‘supervisory dynamics’ (equality, involvement, support and attentiveness); ‘team dynamics’ (intrapersonal team functioning and interpersonal team functioning) and ‘workplace safety culture’ (workplace safety values) on direct and indirect experiences of client-engaged violence. Results from multivariate analysis show that workload characteristics and organisational cultural values of workplace safety had a significant effect on worker experiences of client-engaged violence. The results highlight the importance of creating organisational policies and procedures that support workers in managing workloads and promoting a culture of safety within the work setting.
Myocardial work comes to rescue when afterload-dependency of strain cause false positives
Authors: Sletten OJ , Aalen JM , Remme EW , Khan FH , Hisdal J , Smiseth OA , Skulstad H 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): The Norwegian Health Association

Introduction
Global longitudinal strain (GLS) can detect subclinical left ventricular (LV) dysfunction. GLS measurement is therefore recommended when chemotherapy-induced cardiotoxicity can be suspected. A relative, percentage reduction in GLS ≥8% may indicate subclinical LV dysfunction induced by chemotherapy. Due to afterload-dependency, moderate increase in blood pressure has the potential to cause reductions in GLS beyond this threshold. However, myocardial work incorporates afterload, and may be used to omit false positive outcomes.

Purpose
To investigate if moderate increases in afterload cause clinically relevant changes in strain, and if myocardial work is more robust to such changes.

Methods
Twenty cancer patients (41 ± 14 years) undergoing chemotherapy and twenty healthy controls (49 ± 11 years, NS) were included. All participants were free from concomitant heart disease. GLS was measured by speckle-tracking echocardiography. Global myocardial work was calculated by pressure-strain analysis using a previously validated method to estimate LV pressure (LVP) non-invasively. Recordings were performed before and after 2 minute stress by handgrip.

Results
At baseline, patients had lower GLS (20.1 ± 1.1 vs 22.1 ± 2.5%, p &lt; 0.01) and global myocardial work (1810 ± 203 vs 2051 ± 287 mmHg·%, p &lt; 0.01) than controls. Stress test moderately increased systolic blood pressure, similar in both groups (116 ± 10 to 146 ± 17 mmHg in patients, and 118 ± 12 to 147 ± 21 mmHg in controls). This afterload-enhancement was associated with a decrease in GLS from 20.1 ± 1.1 to 18.4 ± 1.3% in patients, and from 22.1 ± 2.5 to 20.3 ± 2.5% in controls (both p &lt; 0.01). Every second participant, eleven patients and nine controls, experienced a relative reduction in GLS &gt;8%. In contrast, global myocardial work increased during the stress test from 1810 ± 203 to 2002 ± 281 mmHg·% in patients, and from 2051 ± 287 to 2292 ± 398 mmHg·% in controls (both p &lt; 0.01). Figure 1 shows changes in GLS and myocardial work at moderate increase in afterload.

Conclusions
Moderate increase in afterload caused reductions in GLS sufficient to promote over-diagnosis of chemotherapy-induced cardiotoxicity. Global myocardial work has the potential to distinguish true subclinical LV dysfunction from afterload-induced decline in GLS.
Abstract Figure.
Left ventricular force adaptation and cardiac deformation in the progression of aortic stenosis
Authors: Faganello G , Pagura L , Croatto E , Collia D , Furlotti S , Paldino A , Dal Ferro M , Sinagra G , Di Lenarda A , Pedrizzetti G 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.
Introduction. Aortic stenosis (AS) is one of the most common valvular heart diseases; however, the association between left ventricular (LV) myocardial deformation and hemodynamic forces (HDFs) is still mostly unexplored.
Purpose. This study aimed to assess the differences in LV myocardial deformation and HDFs in a large cohort of patients with aortic stenosis retrospectively.
Methods. Two-hundred fifty-four subjects (median age 77 years, 50% women) with preserved LV ejection fraction (LVEF), and mild (n = 87), moderate (n = 92) or severe (n = 75) AS, were included in the study. The 2D LV global longitudinal strain (GLS), circumferential strain (GCS), and HDFs were measured with new software that allowed us to calculate all these values and parameters from the three apical views.
Results. When comparing severe AS to mild AS, LV mass appeared increased while the LV hypertrophy phenotype was concentric (p &lt;0.0001). Along with the progression of the AS, LVEF was decreased. All GLS, GCS, and HDFs parameters were uniformly reduced in severe AS compared to mild AS (p &lt;0.0001), in the same way, LV longitudinal force, LV longitudinal systolic force, and LV impulse have proven to be accurate on ROC curves (AUC 70%, 73% and 73% respectively).
Conclusion. The integrated approach of deformation and cardiac mechanics allows the description of pathophysiological changes during the progression of mild to severe aortic stenosis.
Abstract Figure. Strain parameters and aortic stenosis
Comparison of the T2 effects of three T1 mapping sequences of the myocardium at 3T and 1.5T
Authors: Zhou H , Puntmann V , Nagel E 
Published: February 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.
Purpose
To compare the T2 effects of three T1 mapping sequences of the myocardium at 3T and 1.5T.
Materials and Methods
We measured native T1 values by three T1 mapping sequences (FFM, MPI and LONG) and T2 values of 630 consecutive subjects (patients and healthy volunteers) in a mid-ventricular short axis slice by regions of interest (ROIs) placed conservatively within the septal myocardium. Correlations between myocardial T1 and T2 values were analyzed.
Results
Native T1 values differed significantly depending on the sequence, with MPI providing consistently higher mean values than FFM and LONG, LONG providing higher mean values than FFM (all p &lt; 0.001). T1 by FFM, MPI and LONG in the total population, disease group, non-ischaemic cardiomyopathy group were all weakly related to T2 at 3T. The correlation coefficient of MPI were the highest in the total population and disease group, but there is no significant difference in correlation coefficients (all p &gt; 0.05). Similarly, T1 by FFM, LONG in the total population, disease group, NICM group were all weakly-moderately related to T2 at 1.5T. In the control group, only T1 by MPI was moderately and positively related to T2(r = 0.469, p = 0.037). In the ischaemic cardiomyopathy group, only T1 by MPI was weakly and positively related to T2 (r = 0.334, p = 0.011). In the stress condition, T1 by FFM and MPI was weakly and positively related to T2 (r = 0.280,0.210, p = 0.001,0.012, respectively).

Conclusion
The T2 effects existed in three T1 mapping sequences of the myocardium in varying degrees, we should consider the potential bias from T2 when analyzing the abnormal T1 values of myocardium.
Abstract Figure.