bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Survival Outcomes with or Without Para-aortic Lymphadenectomy in Surgical Patients with Stage IB1-IIA2 Cervical Cancer in China from 2004-2016
Authors: Chen Chunlin , Duan Hui , Zhang Wenling , Zhao Hongwei , Wang Li , Kang Shan , Lin Lihong , Zhao Weidong , Ni Yan , Li Donglin , Chen Jiaming , Fan Huijian , Chen Xiaolin , Bin Xiaonong , Lang Jinghe , Liu Ping 
Published: May 2021

Abstract
Background: Current opinions on whether surgical patients with cervical cancer should undergo para-aortic lymphadenectomy at the same time are inconsistent. The present study examined differences in survival outcomes with or without para-aortic lymphadenectomy in surgical patients with stage IB1-IIA2 cervical cancer.Methods: We retrospectively compared the survival outcomes of 8802 cervical cancer patients with stage IB1-IIA2 (FIGO 2009) from 37 hospitals in mainland China, who underwent abdominal radical hysterectomy + pelvic lymphadenectomy (n=8445) or abdominal radical hysterectomy + pelvic lymphadenectomy + para-aortic lymphadenectomy (n=357).Results: Among the 8802 patients with stage IB1-IIA2 cervical cancer, 1618 (18.38%) patients had postoperative pelvic lymph node metastasis, and 37 (10.36%) patients had para-aortic lymph node metastasis. When pelvic lymph node metastasized, the para-aortic lymph node simultaneous metastasis rate was 30.00% (36/120). The risk of isolated para-aortic lymph node metastasis was 0.42% (1/237). There were no significant differences in the survival outcomes between the para-aortic lymph node unresected and resected groups. No differences in the survival outcomes were found before or after matching between the two groups regardless of pelvic lymph node negativity/positivity. Conclusion: Para-aortic lymphadenectomy did not improve 5-year survival outcomes in surgical patients with stage IB1-IIA2 cervical cancer. Therefore, when pelvic lymph node metastasis is negative, the risk of isolated para-aortic lymph node metastasis is very low, and para-aortic lymphadenectomy is not recommended. When pelvic lymph node metastasis is positive, para-aortic lymphadenectomy should be carefully selected because of the high risk of this procedure.
The Impact of Different Tree Planting Strategies in the Piazzas of a Northern Italian City
Authors: Speak Andrew , Montagnani Leonardo , Solly Hilary , Wellstein Camilla , Zerbe Stefan 
Published: May 2021

Abstract
Achieving urban sustainability goals, and improving the quality of life in cities, are aided by the careful selection of tree species for public green spaces. Numerous trade-offs and synergies are necessary to consider when selecting tree species for successful public green spaces. In this transdisciplinary research we consider the impacts of nine different tree planting scenarios, as modelled with i-Trees, in three piazzas of Bolzano, North Italy. The scenarios consider the opinions of the general public gathered from focused workshops and data collected via a purposefully created smartphone application. Shade provision and aesthetics were the primary factors that influenced citizen tree preferences. Scenarios which included larger tree species generally performed the best due to the greater provision of ecosystem services that arises with larger tree dimensions. Ecosystem disservices also increase with larger trees but can be minimised by careful species selection. Public participation in the planning of urban green spaces can be a beneficial activity which ensures new planning outputs will be well-received whilst providing opportunities for education of citizens about the multiple ecosystem services and disservices in urban contexts.
Laparoscopic Sacrocolpopexy Mesh Removal for Persistent Lumbosacral and Right-sided Gluteal Pain Possibly Caused by Nerve “entrapment”
Authors: Yan Li , Liu Lu Bin , Zhao Cheng Zhi 
Published: May 2021

Abstract
Background: Laparoscopic sacrocolpopexy (LSC), which is an important procedure for vault prolapse, has the advantages of high cure rate, low recurrence rate and little impact on sexual life. Few nerve entrapment complications have been reported in the literature.Case presentation: A 48-year-old woman developed persistent lumbosacral and right-sided gluteal pain after the LSC. During diagnostic laparoscopy, we found that the fixation site deviated by approximately 1.5 cm from the middle of the sacral promontory, the anterior surface of the first sacral vertebra. Hence we removed most of the mesh carefully. S1 nerve “entrapment” caused by this deviation, accompanied by the tissue fibrosis and scar tissue formation, may have been the main cause of pain. The patient’s symptoms resolved after surgical intervention. Conclusions: Our case emphasizes that sacral nerve entrapment is a potential complication of retroperitonealized synthetic mesh placement during sacrocolpopexy. We hope that this report can serve as a reference for dealing with similar situations. For skilled laparoscopists, laparoscopic mesh removal is safe and feasible, but attention should be paid to avoid damage to vessels, ureters and other important organs.
Preparation of 3D Print Scaffolds Fe3O4@ Food Oils/Chitosan/Polylactic Acid/Polyurethane Modified Natural Protein Pegylated for Cardiovascular Blood
Authors: Naderi sholila , Esmaeili Akbar 
Published: May 2021

Abstract
Food oils used in 3D polysaccharides modified with natural protein polymer modified polymer scaffolds can help to reduce blood pressure. This study aimed to use food oils as blood pressure-reducing medicine, bind them to magnetic iron nanoparticles, then bind them to polymeric 3D scaffolds (chitosan, polylactic acid and polyurethane), modified with natural protein and finally separate them. This method made it possible to investigate different variables for nanoparticles. In this project, synthesis polymer, food medicinal oils, modified gelatin, PEGylation, food loading and release process in nanocarrier with different concentrations were examined and cell proliferation was optimized. The results show that 75% of the medicine loaded on iron magnetic NPs containing PEGylated polymer scaffolds was released. Cell proliferation was performed for the sample. In this process, modification of scaffolding with polysaccharides modified with natural protein and food oil increased the efficiency of nanoparticles among the studied Allium sativum oil and Zingiber officinale oils. These behaved very similarly to each other and A. sativum had the biggest effect in lowering blood pressure. The application of food medicine oils in 3D mode scaffolding has not been studied before and this is the first analysis to do so, using nanoparticles.
Induction of Oxidative Stress and Apoptosis in the Injured Brain: Potential Relevance to Brain Regeneration in Zebrafish.
Authors: Anand Surendra Kumar , Sahu Manas Ranjan , Mondal Amal Chandra 
Published: May 2021

Abstract
In the recent years, zebrafish, owing to its tremendous adult neurogenic capacity, has emerged as a useful vertebrate model to study brain regeneration. Recent findings suggest a significant role of the BDNF/TrkB signaling as a mediator of brain regeneration following a stab injury in the adult zebrafish brain. Since BDNF has been implicated in a plethora of physiological processes, we hypothesized that these processes are affected in the injured zebrafish brain. In this small study, we examined the indicators of oxidative stress and of apoptosis using biochemical assays, RT-PCR and IHC to reflect upon the impact of stab injury on oxidative stress levels and apoptosis in the injured adult zebafish brain. Our results indicate induction of oxidative stress in the injured adult zebrafish brain. Also, apoptosis was induced in the injured brain as indicated by increased protein levels of cleaved caspase3 as well as enhanced mRNA levels of both pro-apoptotic and anti-apoptotic genes. This knowledge contributes to the overall understanding of adult neurogenesis in the zebrafish model and raises new questions pertaining to the compensatory physiological mechanisms in response to traumatic brain injury in the adult zebrafish brain.
The Socioeconomic impacts of Eucalypt Plantations on Rural Livelihood in Western Gurage Watersheds, Central-south Ethiopia
Authors: Seware Belay Zerga , Dullo Bikila Warkineh , Fanta Demel Teketay , Abshare Muluneh Woldetsadik 
Published: May 2021

Abstract
Background

Rural landscapes, particularly those close to human settlements and main roads throughout the highlands of Ethiopia, appear greener than the outfields because of eucalypt plantations. The most common factors for eucalypt plantations are two: fuel and construction demands and to generate income.
Objective

This study tried to investigate the socioeconomic impacts of eucalypt plantations in Western Gurage Watersheds located in Central-south Ethiopia. The specific objectives are: to evaluate the socioeconomic importance of eucalypt plantations on the livelihood of farm households, and to assess perceptions on impacts of eucalypt plantation and copping strategies.
Methods

Systematic and purposive sampling method was employed by selecting households with eucalypt woodlots from the list of each Woreda’s Kebeles. Close- and open- ended questionnaires were distributed to every fifth households that possessed eucalypt plantations. Three hundred eighty three questionnaires were distributed and collected from households found in three Woredas (districts) namely Cheha, Enemorna Ener, and Eza located in the Watersheds. To supplement the information critical observations, discussions with focus groups and interviews with key informant were employed. The survey data were analyzed using both qualitative and quantitative techniques. To describe data acquired from critical observations, focus group discussions and key informant interviews; critical and logical qualitative data analysis technique were used. Descriptive and dispersive statistics such as frequency, percentage, mean, variance, standard deviation, p- value and correlation were employed using SPSS Version 20.
Results

The result showed that eucalypt plantation dominated fuel wood and construction consumption and substituted further encroachment to natural forests. From multiple responses given, households prefer planting eucalypts to indigenous trees because it is fast growing (100%), profitable (100%), needs lesser labor (100%), needs lower capital (100%), can be used for multipurpose (100%), and coppice itself fatly (93%). They rated income gained from eucalypt as 2nd next to enset.
Conclusions

Households may continue planting the species particularly for fuel wood and construction need since substituting it by other alternative seems not feasible and challenging. To sustain the livelihood and environment; appropriate management like site selection and substitutions by horticultural and cash crops using micro irrigation schemes for market needs are recommended. Conducting in-depth participatory research and specific policy ratification and promulgation on eucalypt plantations will sustain its utilization and curb the drawbacks.
A Synergistic Mindsets Intervention Protects Adolescents from Social Stress
Authors: Yeager David , Bryan Christopher , Gross James , Krettek Danielle , Santos Pedro , Murray Jared , Graveling Hannah , Johnson Meghann , Jamieson Jeremy 
Published: May 2021

Abstract
Social stress poses a major threat to adolescent health via its effects on internalizing symptoms, such as anxiety and depression. Available interventions to help adolescents improve their stress responses, however, have not been effective in rigorous evaluation studies, or they have been difficult to administer widely. Here we show that replicable improvements in adolescent stress responses can be achieved with a short (~30-minute), scalable synergistic mindsets intervention. This intervention, which is a self-administered online training module, targets both growth mindsets (the idea that people’s intelligence can be developed in response to challenge) and stress-can-be-enhancing mindsets (the idea that people’s stress responses can be fuel for optimal performance). Its goal is to promote positive engagement with stressful events (e.g., learning from failure on a quiz or a conflict with a peer) and to encourage adolescents to use their responses to stressful events and even their bodily symptoms (e.g. racing heart, sweaty palms, butterflies in their stomach) to their advantage. In five double-blind, randomized, controlled trials (total N = 4,091 adolescents), the new synergistic mindsets intervention improved stress-related cognitions (Studies 1-2), cardiovascular reactivity (Study 3), daily internalizing symptoms and cortisol levels (Study 4), and generalized anxiety symptoms during the 2020 COVID-19 lockdowns (Study 5). Effects on downstream outcomes (in Studies 3-5) were stronger among individuals who, at baseline, held the two negative mindsets targeted by the intervention, providing evidence for the proposed mechanisms. Confidence in this conclusion comes from a conservative, Bayesian machine-learning method for detecting heterogeneity.
Counteracting Knee Flexors Strength Could Effectively Prevent the Increase in Post-operative Posterior Tibial Slope in Patients Undergoing Open‑wedge High Tibial Osteotomy
Authors: Ma Wenru , Han Zengshuai , Sun Shengnan , Chen Jinli , Yu Tengbo , Zhang Yi 
Published: May 2021

Abstract
Background A difficult-solved problem is that the posterior tibial slope (PTS) increases after medial open-wedge high tibial osteotomy (OWHTO).Purpose To evaluate effects from knee flexors on changes in the posterior tibial slope after OWHTO and to determine whether counteracting the strength of knee flexors could prevent increase in post-operative PTS.Methods The study retrospectively analyzed 112 subjects (122 knees) [34 males, 78 females; mean age 59.1±6.6 (range 48–76) years; mean body mass index (BMI) 28.06±3.61 kg/m²] who underwent OWHTO. During fixing steel plates, 78 knees keeping suspended and extended to counteract the strength of knee flexors by gravity are comprised the no-flexor group and 44 knees in natural posture without counteracting knee flexors are comprised the flexor group. Patients were clinically assessed according to the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index and a visual analogue pain scale (VAS). Radiological assessment was made according to the changes in the posterior tibial slope between preoperative, 1-day post-operative and final follow-up periods. Ultimately, difference in post-operative PTS changes between the two groups was statistically analyzed. The median follow-up period was 2.2 years (range 1.6–3.7 years).Results In the final follow-up period, significant improvements were observed in the clinical scores of the VAS and WOMAC in both groups (P < 0.001), and no difference was found between the two groups. Radiological assessment showed that the final follow-up PTS was significantly greater than preoperative PTS in the flexor group (t=-6.406, P < 0.001), but no significant increase was seen in the no-flexor group (P =0.482). Increase of PTS in the flexor group was significantly greater than that in the no-flexor group at 1-day postoperative (t=2.243, P=0.030) and final follow-up periods (t=6.501, P<0.001).Conclusion For OWHTO, knee flexors would aggravate the increase in post-operative PTS. Using gravity to counteract the strength of knee flexors when fixing steel plates could effectively prevent the increase in post-operative PTS.
How to Identify Suitable Candidates With Pectus Excavatum for Vacuum Bell Therapy?
Authors: Yi Eunjue , Lee Kwanghyoung , Jung Younggi , Chung Jae Ho , Kim Han Sung , Lee Sungho , Ahn Hyonggin 
Published: May 2021

Abstract
Vacuum bell therapy has been acceptable substitute for pectus excavatum patients who want to improve their appearance but avoid surgical correction. The aim of this study was to assess the pre-treatment characteristics of patients with pectus excavatum and to establish characteristics that can potentially help identify ideal candidates for vacuum bell therapy. Expected improvements in thoracic indices were evaluated using pre-treatment chest computed tomography, which was performed before and after applying a vacuum bell device. Treatment results after 1-year of application were evaluated using changes in the Haller index before and after treatment. The patients were categorized into two groups: those with Haller index less than 0.5 (Group 1) and those with Haller index greater than or equal to 0.5 (Group 2). Pre-treatment Haller index was significantly lower in Group 1 than in Group 2 (3.1±0.46 vs. 4.2±1.14, respectively, p<0.001). The expected improvement in Haller index in Group 2 was significantly higher than that in Group 1 (3.3±0.60 vs. 2.8±0.54, respectively, p=0.001). The cut-off value of the expected improvement in Haller index was 0.46 with a sensitivity of 75.8% and a specificity of 83.3%. Patients who demonstrated pliability with a vacuum bell were identified as suitable candidates.
Assessment of Total and Regional Bone Mineral Density Using Bioelectrical Impedance Vector Analysis in Elderly Population
Authors: Lu Hsueh-Kuan , Lai Chung-Liang , Lee Li-Wen , Chu Lee-Ping , Hsieh Kuen-Chang 
Published: May 2021

Abstract
This study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged over 60 years were recruited from middle Taiwan. The R and Xc were measured using Bodystat Quadscan 4000 at a frequency of 50 kHz. BMD at the whole body, L2-L4 spine, and dual femur neck (DFN), denoted as BMDTotal, BMDL2-L4, and BMDDFN, were calculated using a Hologic DXA scanner. The R-Xc graph was used to assess vector shift among different levels of BMD. BMD was positively correlated with Xc/H and negatively correlated with R/H (p<0.001). The General Linear Model (GLM) regression results were as follows: BMDTotal = 1.473 – 0.002 R/H + 0.007 Xc/H, r = 0.684; BMDL2-L4 = 1.526 – 0.002 R/H + 0.012 Xc/H, r = 0.655; BMDDFN = 1.304 – 0.002 R/H + Xc/H, r = 0.680; p<0.0001. Distribution of vector in the R-Xc graph was significantly different for different levels of BMDTotal, BMDL2-L4 and BMDDFN. R/H and Xc/H were correlated with BMD in the elderly. The linear combination of R/H and Xc/H can effectively predict the BMD of the whole body, spine and proximal femur, indicating that BIVA may be used in clinical and home-use monitoring tool for screening BMD in the elderly in the future.
Diverse Functions Associate With Non-Coding Trans-species Polymorphisms in Humans
Authors: Velazquez-Arcelay Keila , Benton Mary Lauren , Capra John A. 
Published: May 2021

Abstract
Background: Long-term balancing selection (LTBS) can maintain allelic variation at a locus over millions of years and through speciation events. Variants shared between species, hereafter “trans-species polymorphisms” (TSPs), often result from LTBS due to host-pathogen interactions. For instance, the major histocompatibility complex (MHC) locus contains TSPs present across primates. Several hundred candidate TSPs have been identified in humans and chimpanzees; however, because many are in non-coding regions of the genome, the functions and adaptive roles for most TSPs remain unknown. Results: We integrated diverse genomic annotations, with a focus on non-coding regions, to explore the functions of 125 previously identified regions containing multiple TSPs in humans and chimpanzees. We analyzed genome-wide functional assays, expression quantitative trait loci (eQTL), genome-wide association studies (GWAS), and phenome-wide association studies (PheWAS). We identify functional annotations for 119 TSP regions, including 71 with evidence of gene regulatory function from GTEx or genome-wide functional genomics data and 21 with evidence of trait association from GWAS and PheWAS. TSPs in humans associate with many immune system phenotypes, including response to pathogens, but we also find associations with a range of other phenotypes, including body mass, alcohol intake, urate levels, chronotype, and risk-taking behavior. Conclusions: The diversity of traits associated with non-coding human TSPs further support previous hypotheses that functions beyond the immune system are subject to LTBS. Furthermore, several of these trait associations provide support and candidate genetic loci for previous hypothesis about behavioral diversity in great ape populations, such as the importance of variation in sleep cycles and risk sensitivity.
A Random Forest approach to identify metrics that best predict match outcome and player ranking in the esport Rocket League
Authors: Smithies Tim D. , Campbell Mark J. , Ramsbottom Niall , Toth Adam J. 
Published: May 2021

Abstract
Notational analysis is a popular tool for understanding what constitutes optimal performance in traditional sports. However, this approach has been seldom used in esports. The popular esport “Rocket League” is an ideal candidate for notational analysis due to the availability of an online repository containing data from millions of matches. The purpose of this study was to use Random Forest models to identify in-match metrics that predicted match outcome (performance indicators or “PIs”) and/or in-game player rank (rank indicators or “RIs”). We evaluated match data from 21,588 Rocket League matches involving players from four different ranks. Upon identifying goal difference (GD) as a suitable outcome measure for Rocket League match performance, Random Forest models were used alongside accompanying variable importance methods to identify metrics that were PIs or RIs. We found shots taken, shots conceded, saves made, and time spent goalside of the ball to be the most important PIs, and time spent at supersonic speed, time spent on the ground, shots conceded and time spent goalside of the ball to be the most important RIs. This work is the first to use Random Forest learning algorithms to highlight the most critical PIs and RIs in a prominent esport.
Analysis of tool wear and surface roughness in high-speed milling process of aluminum alloy Al6061
Authors: Nguyen Nhu-Tung , Tien Dung Hoang , Tung Nguyen Tien , Luan Nguyen Duc 
Published: May 2021

In this study, the influence of cutting parameters and machining time on the tool wear and surface roughness was investigated in high-speed milling process of Al6061 using face carbide inserts. Taguchi experimental matrix (L9) was chosen to design and conduct the experimental research with three input parameters (feed rate, cutting speed, and axial depth of cut). Tool wear (VB) and surface roughness (Ra) after different machining strokes (after 10, 30, and 50 machining strokes) were selected as the output parameters. In almost cases of high-speed face milling process, the most significant factor that influenced on the tool wear was cutting speed (84.94 % after 10 machining strokes, 52.13 % after 30 machining strokes, and 68.58 % after 50 machining strokes), and the most significant factors that influenced on the surface roughness were depth of cut and feed rate (70.54 % after 10 machining strokes, 43.28 % after 30 machining strokes, and 30.97 % after 50 machining strokes for depth of cut. And 22.01 % after 10 machining strokes, 44.39 % after 30 machining strokes, and 66.58 % after 50 machining strokes for feed rate). Linear regression was the most suitable regression of VB and Ra with the determination coefficients (R2) from 88.00 % to 91.99 % for VB, and from 90.24 % to 96.84 % for Ra. These regression models were successfully verified by comparison between predicted and measured results of VB and Ra. Besides, the relationship of VB, Ra, and different machining strokes was also investigated and evaluated. Tool wear, surface roughness models, and their relationship that were found in this study can be used to improve the surface quality and reduce the tool wear in the high-speed face milling of aluminum alloy Al6061