bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early initiation of intravenous cyclophosphamide and one‐year outcome in super‐refractory cryptogenic‐new onset refractory status epilepticus
Authors: Yorichika Yasufumi , Neshige Shuichiro , Sakahara Hideaki , Ono Narumi , Nonaka Megumi , Tagane Yuichiro , Watanabe Tomoaki , Tachiyama Keisuke , Ishibashi Haruka , Nakamori Masahiro , Shishido Takeo , Aoki Shiro , Ueno Hiroki , Yamazaki Yu , Iizuka Takahiro , Maruyama Hirofumi 
Published: December 2024

AbstractTo explore the potential efficacy of early initiation of intravenous cyclophosphamide (IVCPA), we reviewed consecutive four cases of super‐refractory cryptogenic‐new onset refractory status epilepticus (C‐NORSE) between 2015 and 2023. We compared functional outcomes at 3 months and 1 year after the onset between patients who received IVCPA within 20 days (early‐treated) and those who received it later (late‐treated). All patients (median age: 43 years) had a prodromal fever. Brain MRI revealed symmetrically increased FLAIR signals in the medial temporal lobes of all patients. Despite initiating antiseizure medications (ASMs) and first‐line immunotherapy (intravenous‐methylprednisolone and immunoglobulins) within a median of 3 days from onset, SE persisted >5 days. The diagnosis of C‐NORSE was suggested based on a high C‐NORSE score (6/6). Thus, all patients received IVCPA a median of 15.5 days after seizure onset (three within 20 days and one at 31 days). One of the three early‐treated patients also received tocilizumab. Early‐treated patients exhibited shorter sedation periods (median 29 vs. 75 days) and better 1 year functional status (mRS 1–2 vs. mRS 4) compared to the late‐treated patient. Early initiation of IVCPA and/or tocilizumab, along with ASMs, may contribute to a better one‐year functional status in super‐refractory C‐NORSE patients.Plain Language SummaryThis study demonstrates the potential efficacy of early administration of intravenous cyclophosphamide on one‐year functional status in patients with super‐refractory cryptogenic‐new onset refractory status epilepticus. “Early‐treated patients” who received it within 20 days of seizure onset achieved a good one‐year functional status. The “late‐treated patient” (Case 4) who received it later did not achieve a good functional status. Early initiation of cyclophosphamide, along with antiseizure medications, may contribute to a better one‐year functional status in this population.
Sex Disparities in In‐Hospital Outcomes After Percutaneous Coronary Intervention (PCI) in Patients With Acute Myocardial Infarction and a History of Coronary Artery Bypass Grafting (CABG): A Cross‐Sectional Study
Authors: Yan Rui , Zhang Hui , Shi Bo , Ye Congyan , Fu Shizhe , Wang Kairu , Yang Jie , Yan Ru , Jia Shaobin , Ma Xueping , Cong Guangzhi 
Published: December 2024

ABSTRACTBackground and AimsThe role of sex disparities in in‐hospital outcomes after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in patients with a history of coronary artery bypass grafting (CABG) remains underexplored. This study aimed to identify sex disparities in in‐hospital outcomes after PCI in patients with AMI and a history of CABG.MethodsUsing the National Inpatient Sample database, we identified patients hospitalized for AMI with a history of CABG who underwent PCI between 2016 and 2019. 1:1 propensity score matching was used to minimize standardized mean differences of baseline variables and compare in‐­hospital outcomes.ResultsIn total, 75,185 weighted hospitalizations of patients were identified. Compared with male patients, female patients exhibited elevated risks of in‐hospital mortality (3.72% vs. 2.85%; adjusted odds ratio [aOR] 1.48; 95% confidence interval [CI] 1.14–1.93), major adverse cardiac or cerebrovascular events (MACCEs) (4.96% vs. 3.75%; aOR 1.46; 95% CI 1.18–1.82), bleeding (4.91% vs. 3.01%; aOR 1.56; 95% CI 1.27–1.79), and longer length of stay (4.64 days vs. 3.96 days; β 0.42; 95% CI 0.28–0.55). After propensity matching, female patients remained associated with increased risks of in‐hospital mortality (3.81% vs. 2.81%; aOR 1.37; 95% CI 1.06–1.78), MACCEs (5.08% vs. 3.84%; aOR 1.35; 95% CI 1.08–1.70), bleeding (5.03% vs. 3.11%; aOR 1.57; 95% CI 1.24–2.00), and longer length of stay (4.61 ± 4.76 days vs. 4.06 ± 4.10 days; β 0.39; 95% CI 0.18–0.59). Female patients aged > 60 years were more vulnerable to in‐hospital mortality than were their male counterparts (3.06% vs. 4.15%; aOR 1.56; 95% CI 1.18–2.05).ConclusionsFemale patients who underwent PCI for AMI with a history of CABG had higher risks of in‐hospital mortality, MACCEs, bleeding, and longer length of stay, with in‐hospital mortality rates being particularly pronounced among older patients.
Magnetohydrodynamic Flow of Immiscible Couple Stress and Newtonian Fluids in a Porous Pipe With Navier Slip Effect
Authors: Daba Yitagesu , Gadisa Gosa 
Published: December 2024

ABSTRACTThis work deals with the magnetohydrodnamic (MHD) flow of non‐miscible couple stress and Newtonian fluids within a horizontally‐oriented porous cylinder. The overall flow domain is divided into two separate regions. In the core area, identified as region I, the flow of the couple stress fluid takes place, while in region II, which forms the outer part of the flow area, the flow of Newtonian fluid occurs. The linear Navier slip condition on the cylinder's surface and continuity conditions for velocities and shear stresses, along with vanishing couple stress at the fluid‐fluid surface, have been taken as boundary and interface conditions, respectively. The nonlinear partial differential equations describing the flow situation along with the boundary conditions are first mathematically formulated and, then cast in a dimensionless form. Closed‐form solutions for velocities, wall shear stress, and total flow rate have been obtained by solving the non‐dimensionalized governing equations through the direct method. The influences of different flow parameters on the velocity in both flow areas are depicted graphically. The numerical values of the total flow rate and the wall stress for various flow parameters are also tabulated. The examination of the obtained results indicates that the fluid velocities diminish with increases in the Hartmann number, viscosity ratio, and porosity parameter. Conversely, they escalate with higher Reynolds numbers, pressure gradients, and slip parameters. Furthermore, the increase in the couple stress parameter increases the velocity of the couple stress fluid (core region), while the velocity of the Newtonian fluid (peripheral region) remains nearly constant. The findings of this research align very well with the results documented in the existing literature. This study is novel as it examines, for the first time, the effects of slip and magnetic fields on the flow of two immiscible fluids (couple stress and Newtonian) through a porous medium in cylindrical coordinates.
Mesoporous Lanthanum‐Doped Magnesium Phosphate Nanopowders Promote Healing of Critical‐Size Bone Defects: An In Vivo Study
Authors: Moaness Mona , ElShebiney Shaimaa , Beherei Hanan H. , Mabrouk Mostafa 
Published: December 2024

ABSTRACTTreating severe bone deformities and abnormalities continues to be a major clinical hurdle, necessitating the adoption of suitable materials that can actively stimulate bone regeneration. Magnesium phosphate (MP) is a material that has the ability to stimulate the growth of bones. The current study involved the synthesis of mesoporous MP and lanthanum (La)‐doped nanopowders using a chemical precipitation approach. The nanopowders were analyzed using several techniques, including XRD, FTIR, HR‐TEM, BET, XPS, and FE‐SEM. The results confirmed the nanopowders' size of less than 40 nm and the successful incorporation of La3+ ions into the MP structure. The bioactivity of the materials was assessed in vitro using simulated bodily fluid (SBF) at 37°C for a duration of 14 days in a shaker incubator (50 rpm). The SEM showed that a bone‐like apatite layer formed quickly on the nanopowders' surface, proving that they have unique bioactive properties. The EDX spectra confirmed the presence of Ca, P, Mg, and La elements after immersion in SBF. The MP nanopowders, both with and without La doping, demonstrated the capacity to stimulate bone formation in a rat femoral bone defect model over a 28‐day duration. Radiographic and histological studies showed that the La‐doped MP nanopowders greatly improved bone repair and regeneration in comparison to the La‐free nanopowders. Finally, the readily producible mesoporous MP nanomaterials, especially those with increased La doping (up to 7 wt%), exhibit significant potential for the restoration of large bone defects. Hence, fabricated nanopowders have immense promise for repairing bone criterion defects.
Fear of missing out and internet addiction: A survey of dental students
Authors: Harorli Hatice , Harorli Osman Tolga 
Published: December 2024

AbstractPurposeFear of missing out (FoMO) and internet addiction are significant phenomena in today's digital age. This study aims to explore the relationships between FoMO levels, internet addiction levels, time spent on the internet, and other factors among dental students.MethodsData were collected from 252 dental students, including 127 females. Information gathered included FoMO levels, internet addiction levels, university year, age, time spent on the internet, and income level. Correlation analysis and statistical tests were performed to explore relationships between variables.ResultsDescriptive statistics revealed that the majority of participants were between 21 and 24 years old, with most reporting a middle income. The correlation analysis showed a moderate positive relationship between FoMO and internet addiction (r = 0.356, p < 0.001). Time spent on the internet showed a moderately strong positive correlation with internet addiction levels (r = 0.583) and a moderate correlation with FoMO levels (r = 0.316). Average FoMO and internet addiction levels varied across university years, showing fluctuations without a consistent trend.ConclusionFoMO is positively associated with internet addiction and time spent on the internet, highlighting its potential influence on dental students in the digital age. Addressing FoMO and promoting healthier digital habits may help mitigate internet addiction and excessive internet usage. Further research is needed to explore causal relationships and other influencing factors.
Efficacy of heel lifts for insertional Achilles tendinopathy (LIFTIT): A randomised feasibility trial
Authors: Bourke Jaryd , Munteanu Shannon , Garofolini Alessandro , Taylor Simon , Malliaras Peter 
Published: December 2024

AbstractObjectivesInsertional Achilles tendinopathy is a common and disabling condition. This trial aimed to determine the feasibility of conducting a parallel group randomised trial to evaluate the efficacy of heel lifts compared to a sham intervention for reducing pain intensity associated with insertional Achilles tendinopathy.MethodsTwenty‐six people with insertional Achilles tendinopathy were randomised to either the heel lift group or sham intervention group. Outcome measures were obtained at baseline, 4, 8 and 12 weeks. The primary outcome was feasibility, evaluated according to demand (recruitment rate and conversion rate), acceptability, adherence, adverse events and retention. Limited efficacy testing was conducted on secondary outcome measures including pain intensity, function, physical activity, health‐related quality of life, use of co‐interventions and global rating of change.ResultsBetween August 25, 2023, and April 7, 2024, we recruited and tested 26 participants (aged 28–65 years, mean [SD] 51 [8]). The pre‐determined thresholds were met for demand, acceptability, adherence, retention, pain intensity, function, quality of life and global rating of change and partly met for adverse events, physical activity and use of co‐interventions. Between 47 and 241, participants will be needed for a fully powered randomised trial.ConclusionIn its current form, a randomised trial of heel lifts compared to a sham intervention is feasible. However, future triallists may need to consider strategies to manage the risk of adverse events and plan to adjust the analyses to account for the use of co‐interventions.Trial registration: ACTRN12623000721606.
Altered lipid profile and reduced neuronal support in human induced pluripotent stem cell‐derived astrocytes from adrenoleukodystrophy patients
Authors: Ferrer Roberto Montoro , Jaspers Yorrick R. J. , Dijkstra Inge M. E. , Breeuwsma Nicole , van Klinken Jan‐Bert , Romero Cato , Engelen Marc , Kemp Stephan , Heine Vivi M. 
Published: December 2024

AbstractX‐linked adrenoleukodystrophy (ALD) is a peroxisomal disorder resulting from pathogenic variants in the ABCD1 gene that primarily affects the nervous system and is characterized by progressive axonal degeneration in the spinal cord and peripheral nerves and leukodystrophy. Dysfunction of peroxisomal very long‐chain fatty acid (VLCFA) degradation has been implicated in ALD pathology, but the impact on astrocytes, which critically support neuronal function, remains poorly understood. Fibroblasts from four ALD patients were reprogrammed to generate human‐induced pluripotent stem cells (hiPSC). hiPSC‐derived astrocytes were generated to study the impact of ALD on astrocytic fatty acid homeostasis. Our study reveals significant changes in the lipidome of ALD hiPSC‐derived astrocytes, characterized by an enrichment of VLCFAs across multiple lipid classes, including triacylglycerols, cholesteryl esters, and phosphatidylcholines. Importantly, ALD hiPSC‐derived astrocytes not only exhibit intrinsic lipid dysregulation but also affect the dendritic tree complexity of neurons in co‐culture systems. These findings highlight the cell‐autonomous effects of pathogenic variants in the ABCD1 protein on astrocytes and their microenvironment, shed light on potential mechanisms underlying ALD neuropathology, and underscore the critical role of astrocytes in neuronal health.
Nutrition provision over time in longer stay critically ill patients: A post hoc analysis of The Augmented vs Routine Approach to Giving Energy Trial
Authors: Viner Smith Elizabeth , Lange Kylie , Peake Sandra , Chapman Marianne J. , Ridley Emma J. , Rayner Christopher K. , Chapple Lee‐anne S. 
Published: December 2024

AbstractBackgroundLimited literature exists on nutrition practices for long‐stay patients in the intensive care unit (ICU). We aimed to compare nutrition practices in the first and second weeks of an ICU admission.MethodA post hoc exploratory analysis of The Augmented vs Routine Approach to Giving Energy Trial (TARGET) randomized controlled trial (RCT) was undertaken. Inclusion criteria were: enrolled in TARGET on day 1 or 2 of ICU admission and ICU length of stay (LOS) >14 days. Clinical characteristics are described, and nutrition delivery and management compared between days 1–7 and 8–14. Data are n (%), mean ± SD, median (interquartile range [IQR]), or mean difference (MD) and 95% confidence interval (95% CI), with P < 0.05 considered significant.ResultsData from 664 patients were analyzed (56.2 ± 16.3 years; 61% male; body mass index 29.2 ± 7.5 kg/m2 and APACHE II 21.9 ± 8.1). When comparing days 1–7 to 8–14: (1) energy delivery was greater (all sources: 1826 ± 603 vs 1729 ± 689 (MD: 97 [95% CI: 52–140] kcal/day, P < 0.001) and nonnutrition sources: 317 ± 230 vs 192 ± 197 (MD 125 [95% CI: 111–139] kcal/day; P < 0.001); (2) protein delivery was similar (66 ± 20 vs 68 ± 24 (MD: −1.4 [95% CI: −3.2 to 0.4] g/day; P = 0.125]); and (3) fewer patients received parenteral nutrition (PN) (5% vs 9%, P < 0.001) or small intestine feeding (3% vs 8%; P < 0.001).ConclusionIn this post hoc analysis, patients with an ICU LOS >14 days had greater energy delivery and fewer patients received PN or small intestine feeding during days 1–7 than days 8–14. Uncertainty remains regarding whether these data reflect usual practice and the clinical implications of this.
Hydrolyzation‐Free Characterization of Acetalated Dextran via 2D Correlated Raman Spectroscopy
Authors: Plitzko Julian , Köhler Thorben , Meyer‐Zedler Tobias , Schubert Stephanie , Schmitt Michael , Popp Jürgen 
Published: December 2024

ABSTRACTThis study demonstrates a hydrolysis‐free approach for characterizing acetalated dextran derivatives using Raman spectroscopy combined with two‐dimensional correlation spectroscopy (2D‐COS). Traditional methods like 1H‐NMR spectroscopy rely on hydrolysis and are constrained by the time‐sensitive detection of volatile acetone. Raman spectroscopy, as a non‐destructive technique, was applied to analyze time‐dependent acetalation of methoxy and ethoxy acetalated dextran derivatives (AcDex and AceDex). By employing 2D‐COS, time‐resolved Raman spectral changes revealed key marker bands associated with kinetic (acyclic) and thermodynamic (cyclic) substitution products. The observed Raman peak ratios corresponded well with those derived from 1H‐NMR spectroscopy, confirming the accuracy of the method. This approach not only eliminates the need for hydrolysis but also provides a robust, time‐independent tool for tracking acetalation, enabling precise control over polymer properties. The findings underscore the potential for Raman spectroscopy in real‐time monitoring and optimization of dextran‐based polymer synthesis.
Royal Canadian Mounted Police cadets’ exposure to potentially psychologically traumatic events during the Cadet Training Program
Authors: Andrews Katie L. , Maguire Kirby Q. , Jamshidi Laleh , Afifi Tracie O. , Nisbet Jolan , Shields Robyn E. , Teckchandani Taylor A. , Asmundson Gordon J. G. , Brunet Alain , Lix Lisa M. , Sauer‐Zavala Shannon , Sareen Jitender , Keane Terence M. , Neary J. Patrick , Carleton R. Nicholas 
Published: December 2024

AbstractLifetime exposures to potentially psychologically traumatic events (PPTEs) among Royal Canadian Mounted Police (RCMP) cadets starting the Cadet Training Program (CTP) appear lower than exposures reported by serving RCMP, but the prevalence of PPTE exposures during the CTP remains unknown. The current study assessed PPTE exposures during the CTP and examined associations with mental disorders among RCMP cadets. Participants were cadets (n = 449, 24.7% women) from the larger RCMP Longitudinal Study who self‐reported critical incidents, PPTE exposures, and mental health disorder symptoms at pretraining and predeployment. Most participants reported no exposures to a PPTE (n = 374, 83.3%) during the CTP. Participants who reported any PPTE exposure (n = 75, 16.7%; i.e., direct or indirect) most commonly reported serious transport accidents, physical assault, and sudden accidental death. The most common direct PPTEs (i.e., “happened to me”) during the CTP were physical assault (n = 13), other unwanted or uncomfortable sexual experience (n = 11), and serious transportation accident (n = 8). The total number of PPTE types reported at predeployment was associated with increased odds of screening positive for any mental health disorder, aOR = 1.22, 95% CI [1.01, 1.49], p = .049, and positively associated with mental health disorder symptoms, ps < .001. These results provide the first assessment of PPTE exposure among RCMP cadets during the CTP, indicating that 16.7% of cadets experience PPTEs directly or indirectly. The PPTEs reported by cadets may help inform additional opportunities to further increase safety during training.
Impact of Knowledge Management Process on Organizational Performance: The Mediating Role of Technological Innovation
Authors: Wongmahesak Kittisak , Wongsuwan Navaporn , Akkaya Bulent , Palazzo Maria 
Published: December 2024

ABSTRACTThe prime objective of the current study is to explore the knowledge management process includes knowledge creation, knowledge sharing, knowledge storage, and knowledge utilization on the organizational performance. Therefore, this study examines the ways through which technological innovation may contribute to knowledge management implementation and thus result in improved organizational performance and innovation. The sample of this research was 364 manufacturing companies in Indonesia. The questionnaire was used as a tool to collect data via email and follow‐up with phone calls. To perform data analysis, the Partial least square structural equation modelling is implemented. Findings indicate that knowledge acquisition, exploitation, protection, and integration significantly and positively influence the innovative ability of an organization. Thus, in order to test these factors in different contexts, more studies must be performed. In the current study, the role of Knowledge Management Process was highlighted for increasing the organization's innovative capability.
Worse survival and higher rates of relapse in U.S. Armenians with papillary thyroid cancer
Authors: Tsai Karen , Arca Katerina , Ituarte Philip H. G. , Gernon Thomas , Salehian Behrouz , Bell Diana , Maghami Ellie 
Published: December 2024

AbstractObjectivesPapillary thyroid cancer (PTC) is the most frequent subtype of thyroid cancer with overall favorable survival. Currently, little is known about the PTC experience within the United States (U.S.) Armenians. We performed the first study comparing clinicopathologic variables and clinical outcomes of U.S. Armenian PTC patients to a matched control group of non‐Armenians.MethodsWe performed a single‐center, retrospective, case–control study of adult Armenian PTC patients who received care at COH from 2005 to 2022. Armenian ethnicity was determined by surnames ending in “‐ian” and “‐yan”. We report and compare clinicopathologic presentation and disease outcomes with a gender‐ and age‐matched control non‐Armenian population.ResultsFifty‐eight Armenian patients comprised our study cohort. Positive margin status (p = .038), angioinvasion (p = .006), and extrathyroidal extension (p = .014) were more prevalent in the Armenian population. Higher rates of both persistent disease and death due to disease were seen in the Armenians regardless of age groupings. Multivariable analysis revealed significant impact of Armenian status on outcomes. Calculated 5‐ and 10‐ year disease‐specific survival rates in the Armenian cohort were 88% and 73.2%, respectively, compared with 100% and 94.6% in the non‐Armenian group (p < .002). The 5‐ and 10‐ year progression‐free survival was worse in the Armenian group at 61.8% and 50.1%, respectively, compared with 87.5% and 87.5% in the non‐Armenian group (p < .001).ConclusionArmenian PTC patients displayed more aggressive disease than non‐Armenians. In addition, Armenian PTC patients had higher incidence of disease relapse and worse clinical outcomes.Level of Evidence5
Z‐Average of Cross‐Linked Copolymers and Branched Polycondensates
Authors: Bachmann Rolf , Bendler John T. 
Published: December 2024

AbstractThe theory of Odle et al. for the z‐average of branched polycondensates is extended to the general case of co‐cross‐linking of primary chains with different functionalities. Examples are given for free radical and step growth polymerization. For polycondensates, assuming surplus of one functionality and complete conversion, a simple formula for the degree of polymerization DPz for functional groups is derived:

(fw, fz, gw, gz: weight and z‐averages of the functionalities of the monomers). The formula is applied to the branched step growth polymerization of monomers A2 + Af +B2 with reactive groups A and B and functionalities 2 and f > 2. The functionality f has practically no influence on the weight averages DPw and Mw if calculated as a function of the relative branching density ρr = ρ/ρc, where ρc = Af, c/(Af, c + A2) and Af, c is the critical value at the gel point. The z‐averages become increasingly larger with increasing f and the ratio DPz(f)/DPz(f = 3) is linear in ρr and f.