bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of ultrasonic densitometry in assessing bone mineral density and determining the 10-year risk of osteoporotic fractures in older women in the family doctor practice
Authors: Lukianets Yevheniia 
Published: August 2021

Osteoporosis is the fourth most common disease after cardiovascular, cancer and endocrine diseases. With an increase in life expectancy, it becomes one of the main causes of deterioration in health and an increase in mortality.
The aim of the study. To identify women with low bone density using ultrasound densitometry and assess the risk of osteoporotic fractures.
Materials and methods. The study was based on a survey of 31 women in the Odessa region, the average age of the subjects was 57±9.1 years, the average body weight was 75.74±12.5 kg, height 162.8±0.1 cm, the average BMI was 28.57±4.5. All women were divided into groups by age with a ten-year interval and by densitometry indices.
Results. Decrease in bone density was found in 51.6 % of examined women. The lowest BMD was in the age group of 70–79 years, and the largest numbers of respondents with osteopenic changes were at the age of 50–59. A linear correlation was found between BMD and age at the level of significance p=0.007. The linear regression equation is: t=-0.03968 *age+1.268, (r=-0.473). In women with osteopenia, a significant increase in indicators was found for almost all algorithms for assessing the 10-year risk of fractures at p<0.05 (except for FRAX Hiр without BMD (p=0.087)) and a significant decrease in ultrasound densitometry indicators compared with women with normal BMD. Women with fractures had significantly higher scores according to the FRAX Total algorithms without BMD (p=0.002), FRAX Hiр without BMD (p=0.004) and Q-fracture Hiр (p=0.044).
Conclusions. Most women had osteopenic manifestations according to ultrasound densitometry. Age significantly correlates with BMD parameters. The numbers of women with changes in the structure of bone tissue increases with age, and, after 70 years, all women have osteopenic manifestations. The algorithms for assessing the 10-year risk of fractures FRAX and Q-Fracture reliably correlate with densitometry indicators. The combination of ultrasound densitometry with algorithms for assessing the risk of osteoporotic fractures significantly increases the diagnosis of osteoporosis
POLITENESS/IMPOLITENESS IN CONFLICT DIALOGICAL DISCOURSE: PROSODY ASPECT
Authors: Pelivan O.K. 
Published: August 2021

The given article presents an experimental phonetic investigation, which deals with a comprehensive analysis of English-language formal and informal conflict dialogues. It focuses on the study of various types of the investigated conflict dialogues intonational structure.The basic criteria of the practical material classification are: 1) the degree of relations formality between the collocutors and 2) politeness/impoliteness. According to these criteria the investigated conflict dialogues were classified as formal polite, formal impolite, informal polite and informal impolite. The recorded speech was investigated with the help of computer and statistical analyses which allowed to reveal those elements of prosody which actualize politeness/impoliteness in various types of the investigated conflict dialogues. The prosodic means that most clearly differentiate the investigated dialogical units are the pitch and intensity range, the pitch peaks, the average syllable duration, the average duration of the emphatic centre, the pause volume, types of pauses between the key remarks. The pitch and intensity peaks that coinside with the emphatic centre of a dialogical unity are greatly important for actualizing emphasis. The speech of collocutors who try to remain polite in a formal conflict situation is characterised by a normal tempo with the tendency to slowing down, a mid loudness, a mid pitch range that is due to the formal and official speech situation that forces the interlocutors to follow status subordination. An impolite formal conflict is characterized by a greater degree of emotionality than a polite formal one, as collocutors do not always follow the rules and standards of a formal situation behaviour being rude and harsh with their speech partners. At the prosodic level it is expressed by a faster tempo, a greater loudness and a wider pitch range than in the polite formal communication. The polite informal conflict communication is more emotional and natural than the polite formal one, but less emotional and natural than the impolite informal one. On the one hand the informal situation gives complete freedom to choose emotions and ways of their realization but on the other hand the desire to be polite in order not to offend the speech partner forces the collocutors to restrain their negative feelings in the polite formal conflict communication. The impolite informal conflict is the most emotional and uncontrolled. Expressiveness and uncontrollability in the impolite informal conflict are caused by the the speech situation informality, unwillingness and no need to restrain, complete freedom of choice of verbal and nonverbal means. At the prosodic level this type of conflict interaction is characterised by a high loudness, an accelerated tempo and a wide pitch range of the voice. The conducted research enabled us to state that conflict dialogical discourse represents a peculiar type of speech with a specific prosodic structure.
Insulin choice in feline diabetes mellitus
Authors: Gomez Mejias Yaiza 
Published: August 2021

PICO question
In cats with diabetes mellitus, do protamine zinc insulin (PZI) and glargine show a similar effect in reducing clinical signs and hypoglycaemia episodes?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
The number and type of study designs that were critically appraised was one. This study was a non-randomised retrospective trial. A systematic review was also found, which analyses the influence of insulin in diabetic remission
Strength of evidence
Weak
Outcomes reported
Compared to PZI, using glargine in recently diagnosed diabetic cats fed exclusively an ultra-low carbohydrate-high protein canned diet, may result in lower fructosamine and mean 12 hour blood glucose concentrations as well as less episodes of hypoglycaemia
Conclusion
In view of the strength of evidence and the outcomes from the study the following conclusion is made: in cats with diabetes mellitus where currently licensed insulin fails to result in a good glycaemic control, glargine may be considered

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Somatik Belirti Bozukluğu: Tarihsel Süreç ve Biyopsikososyal Yaklaşım
Authors: ÇETİN Şahabettin , SÖZERİ VARMA Gülfizar 
Published: August 2021

Somatizasyon zihin-beden ilişkisinin derinden hissedildiği bir kavramdır. Ortaya çıkmasında biyolojik, bilişsel, psikodinamik ve
kültürel etmenlerin katkısı bulunmaktadır. Bir ruhsal bozukluğun belirtisi olarak somatizasyonun tanımı, oluş nedenleri, sürdürücü
etkenleri ve tedavisi çok yönlü ve karmaşıktır. Bu bozukluk tarihsel süreçte üzerinde en çok tartışılan konulardan biridir. DSM’nin
son baskısı ile birlikte “Somatik Belirti Bozuklukları ve İlişkili Bozukluklar” başlığıyla sınıflandırmada yer almıştır. Somatik belirti
bozukluğu yaşam kalitesinin azalmasına, yeti kaybına ve sağlık hizmetlerinde yüksek maliyete yol açmaktadır. Bu haliyle hastalıkla
ilgili belirtileri biyopsikososyal bütünlük içinde ele almak kaçınılmaz olmaktadır. Bu çalışmada somatik belirti bozukluğunun
tarihsel sürecinin özetlenmesi, oluş nedenlerinin ve temel tedavi yaklaşımının biyopsikososyal bütünlük içinde sunulması
amaçlanmıştır.
TEACHING ENGLISH VOCABULARY ONLINE: IS THE SCREEN A BARRIER?
Authors: Zabolotna Oksana , Zagoruiko Liudmyla , Panchenko Ielyzaveta , Plotnikov Yevhen 
Published: August 2021

This paper presents mixed-method research on teaching vocabulary online using a combination of quantitative (bibliometric approach) and qualitative (expert evaluation based on Delphi technique) methods to answer three research questions: Which tools in teaching language with technology have been described in research publications? Which tools are frequently addressed in EFL Methodology course in Ukrainian universities for teaching vocabulary online? Which tools and methods require more information for teaching vocabulary online? To answer the first research question, the authors have used a bibliometric approach to analyse the topic-related articles in the eight most relevant journals from the Scopus Database between 2011 and 2020. The authors have encountered few literature review articles tracking the developments in this research area and no articles using bibliometric methods or science maps. After finalising and structuring the bibliometric analysis data, the authors have used the Delphi method with the British Council experts who were involved in the New Generation School Teacher Project. The experts who are EFL Methodology teachers at 7 Ukrainian Universities have shared their experience in using the tools identified by the bibliometric analysis and listed the usability precedency and hurdles with their recommendations. The experts assisted in answering the research questions about the tools addressed in the EFL methodology course and those that require some consideration. As a result, the findings are collated and shared with EFL teachers, and they can gain valuable insights into the current state of the research and practice in this area. In the discussion part, the authors familiarise EFL teachers with the newest resources that provide information about the understudied areas.
A EVOLUÇÃO DA CANOA MONÓXILA EM PERNAMBUCO, BRASIL (SÉCULOS XVI ao XX)
Authors: Souza Carlos Celestino Rios e , Lins Júnior Hamilton Marcelo Morais 
Published: August 2021

A canoa monóxila, popularmente conhecida como canoa de um pau só, é uma embarcação utilizada pelos indígenas do Brasil desde antes da chegada dos primeiros navegantes portugueses no século XVI. Apesar do crescente desenvolvimento tecnológico ocorrido em Pernambuco ao longo dos últimos cinco séculos, a canoa foi objeto de uma série de modificações adaptativas. O presente trabalho procura explicar a evolução da tecnologia da canoa monóxila, relacionando as transformações e os acréscimos introduzidos no casco monóxilo e as variáveis ambientais, socioeconômicas e históricas entre os séculos XVI e XX. O presente artigo se mostra relevante diante da inexistência de trabalhos de cunho acadêmico que versem sobre a tecnologia das embarcações tradicionais de Pernambuco, cuja primeira datação de um artefato náutico é anterior ao descobrimento do Brasil. ABSTRACTThe dugout canoe, popularly known as “canoa de um pau só”, is a boat used by the natives of Brazil since before the arrival of the first Portuguese navigators in the 16th century. Despite the growing technological development occurred in Pernambuco over the past five centuries, the canoe was subjected to many adaptive changes. This paper seeks to explain the evolution of the dugout canoe’s technology, relating the changes and additions introduced upon its hull with the environmental, socioeconomic and historical variables from the sixteenth to the twentieth century. This article is relevant, given the lack of academic works about the technology of traditional boats of Pernambuco and for obtaining the first dating from a nautical artifact prior to the discovery of Brazil.Key Words: Maritime Archaeology; Dugout Canoe; Dating
Integrated Metabolic and Gene Expression Profiling Reveals New Therapeutic Modalities for Rapidly Proliferating Breast Cancers
Authors: Liao Chengheng , Glodowski Cherise Ryan , Fan Cheng , Liu Juan , Mott Kevin Raynard , Kaushik Akash , Vu Hieu , Locasale Jason , McBrayer Samuel K , DeBerardinis Ralph , Perou Charles , Zhang Qing 
Published: August 2021

Abstract
Metabolic dysregulation, although a prominent feature in breast cancer, remains undercharacterized in patient tumors. By performing untargeted metabolomics analyses on triple-negative breast cancer (TNBC) and Estrogen Receptor (ER) positive patient breast tumors, as well as TNBC patient-derived xenografts (PDXs), we identified two major metabolic groups independent of breast cancer histological subtypes: a “Nucleotide/Carbohydrate-Enriched” group and a “Lipid/Fatty Acid-Enriched” group. Cell lines grown in vivo more faithfully recapitulate the metabolic profiles of patient tumors. Integrated metabolic and gene expression analyses reveal genes that strongly correlate with metabolic dysregulation and predict patient prognosis. As a proof-of-principle, targeting Nucleotide/Carbohydrate-Enriched TNBC cell line or PDX xenografts with a pyrimidine biosynthesis inhibitor, and/or a glutaminase inhibitor, led to therapeutic efficacy. In addition, the pyrimidine biosynthesis inhibitor presents better therapeutic outcomes than chemotherapy agents in multiple murine TNBC models. Our study provides a new stratification of breast tumor samples based on integrated metabolic and gene expression profiling, which guides the selection of newly effective therapeutic strategies targeting rapidly proliferating breast cancer subsets. In addition, we develop a public, interactive data visualization portal (http://brcametab.org) based on the data generated from this study.
Complete genome sequence of Chryseobacterium sp. ZHDP1 with protease activity
Authors: Zhao Huanshuai , Wang Jianxin , Huang Jiamao , Ma Yuncheng , Chen Yunfei , Tao Chenzhi , Wang Jiangqi , Jin Linqian , Wang Dingquan , Qu Wu 
Published: August 2021

Abstract
This study reported a complete genome of Chryseobacterium sp. ZHDP1 isolated from the soils of a seafood market. The ZHDP1 genome with a size of 4,917,748 bp and a GC content of 35.95% possessed 4,478 coding genes, 5 rRNA genes, 26 sRNA genes, and 89 tRNA genes. The 16S rRNA gene sequence of ZHDP1 had a maximum similarity of 99.07% with that of C. gambrini 5-1St1a. The maximum values of average nucleotide identity and DNA-DNA hybridization of ZHDP1 genome were 91.39 and 47.8, respectively, which were lower than the thresholds for a new genome. Different protease genes were annotated in the genome of ZHDP1, and the protease activity was also detected in the fermentation broth of ZHDP1. Furthermore, the activity of protease in the fermentation broth was optimized through temperature, pH, and metal irons, and the results showed that 60°C and pH 7.0 were the optimum conditions and Fe3+ could positively increase the protease activity of ZHDP1. This study provides the first insight into the novel genomic information of Chryseobacterium sp. ZHDP1 and its protein-degrading ability, thereby broadening our knowledge of the industrial potentials in genus Chryseobacterium strains.
Trace Metals and Organochlorine Pesticide Residues in Imported Fishes in Bangladesh and Human Health Risk Implications
Authors: Islam Md. Monirul , Avha Nusrat Jahan , Ahmed Shamim , Akbor Md. Ahedul , Islam Md. Sofiqul , Mostafiz Farhana , Habibullah-Al-Mamun Md. 
Published: August 2021

Abstract
Substantial quantity of fish has been imported to Bangladesh without adequate food safety assessment which can pose a serious health risk to local people. This study analyzed the trace metals and organochlorine pesticides residues and the associated human health risk in 33 imported fishes (9 species) from four countries (India, Myanmar, Oman and United Arab Emirates) collected from three different ports (Benapole, Bhomra, and Chittagong) of Bangladesh with invoice lists from the port authorities. Trace metal concentrations were determined using graphite furnace absorption spectrometry and flame absorption spectrometry. The two organochlorine pesticides (Aldrin and Chlordane) residues were determined by GC-MS and found as below detection level (BDL). The trace metal concentrations (mg/kg-ww) in imported fish samples ranged as: As: 0.008 to 0.558; Pb: 0.004 to 0.070; Cr: 0.010 to 0.109; Cd: 0.00 to 0.083; Ni: 0.011 to 0.059; Co: BDL to 0.067; Mn: BDL to 0.0780; Fe: 1.780 to 10.77; Cu: 0.055 to 0.632; and Zn: 0.898 to 9.245. Concentrations of As and Cd were higher than the food safety guideline. Considering the source country of imported fishes, fish samples from Oman were mostly contaminated by the trace metals. The estimated daily intake (EDI) was higher for As and Cr. However, the target hazard quotient (THQ) for individual metal and total THQ for combined metals were lower than 1, indicating no apparent non-carcinogenic health risk for consumers. But target cancer risk (TR) was higher for As, and Ni and the values exceeded the acceptable range indicating a high carcinogenic risk for the local people. Therefore, extensive monitoring of these toxic chemicals is needed prior to import these fishes to the country. Given the self-sufficiency in fish production this study also argues whether Bangladesh needs to import the fishes at all.
Neurophysiological Effects of Dry Needling in Patients with Neck Pain, A Randomized Clinical Trial
Authors: Martín-Sacristán Luis , Calvo-Lobo Cesar , Pecos-Martín Daniel , Fernández-Carnero Josue , Alonso-Pérez Jose Luis 
Published: August 2021

Abstract
The purpose was to determine the efficacy of deep dry needling (DDN) applied on an active myofascial trigger point (MTrP) versus a latent-MTrP versus a non-MTrP location, on pain reduction and cervical disability, in patients with chronic neck pain. A randomized, double-blind clinical trial design was used. A sample of 65 patients was divided into non-MTrP-DDN, active-MTrP-DDN and latent-MTrP-DDN groups. The visual analog scale (VAS), reproduction of the patient’s pain, number of local twitch responses, pressure pain threshold (PPT) and Neck Disability Index (NDI) were assessed before, during and after the intervention and up to 1 month post-intervention. The active-MTrP-DDN-group reduced pain intensity more than non-MTrP-DDN-group after a week and a month (p<0.01). Active-MTrP-DDN-group showed the greatest improvement in tibialis muscle PPT. An association was found with a higher percentage of subjects in whom their neck pain was reproduced when the active-MTrP (77.3%) and the latent-MTrP (81.8%) were treated. The application of DDN on an active-MTrP in the upper trapezius muscle shows greater improvements in pain intensity after one week and one month post-intervention, as well as lesser improvement in PPT in the tibialis muscle, compared to DDN applied in latent-MTrPs or outside of MTrPs in patients with neck pain
Constrained Control Methods for Lower Extremity Rehabilitation Exoskeleton Robot Considering Unknown Perturbations
Authors: Tian Jin , Yuan Liang , Xiao Wendong , Ran Teng , Zhang Jianbo , He Li 
Published: August 2021

Abstract
In this paper, trajectory tracking control is investigated for lower extremity rehabilitation exoskeleton robot. Unknown perturbations are considered in the system which are inevitable in the reality. The trajectory tracking control is constructively treated as constrained control issue. To obtain the explicit equation of motion and analytical solution of lower extremity rehabilitation exoskeleton robot, Udwadia-Kalaba theory is introduced. Lagrange multipliers and pseudo variables are not needed in Udwadia-Kalaba theory, which is more superior than Lagrange method. On the basic of Udwadia-Kalaba theory, two constrained control methods including trajectory stabilization control and adaptive robust control are proposed. Trajectory stabilization control applies Lyapunov stability theory to modify the desired trajectory constraint equations. A leakage-type of adaptive law is designed to compensate unknown perturbations in adaptive robust control. Finally, comparing with nominal control and control method in [32], simulation results demonstrate the superiority of trajectory stabilization control and adaptive robust control in trajectory tracking control.
Neoadjuvant Study of Niraparib in Patients With HER2-Negative, BRCA-Mutated Resectable Breast Cancer
Authors: Spring Laura , Han Hyo , Liu Minetta , Hamilton Erika , Irie Hanna , Santa-Maria Cesar , Reeves James , Pan Peng , Shan Ming , Tang Yongqiang , Graham Julie , Hazard Sebastien , Ellisen Leif , Isakoff Steven 
Published: August 2021

Abstract
This study evaluated neoadjuvant niraparib antitumor activity and safety in patients with localized HER2-negative, BRCA-mutated breast cancer. Twenty-one patients received niraparib 200 mg once daily in 28-day cycles. After 2 cycles, tumor response (≥30% reduction from baseline) by MRI was 90.5% and 40.0% (6/15) of patients who only received niraparib (2–6 cycles) had pathological complete response. No new safety signals were identified and high niraparib intratumoral concentration was observed.
Barriers and Facilitators to Implementation of a Telephone Follow-Up Program for Severely Injured Trauma Patients – A Process Evaluation
Authors: Wake Elizabeth , Brandenburg Caitlin , Heathcote Kathy , Dale Kate , Campbell Don , Cardona Magnolia 
Published: August 2021

Abstract
Background: Survival rates following major trauma are increasing. Understanding the longitudinal outcomes of major trauma can promote successful recovery. A novel, hospital-led telephone follow-up program was implemented by a multi-disciplinary clinical trauma service team at a Level I trauma centre. This evaluation was conducted to examine what factors promoted or impeded the program’s implementation.Methods:A prospective mixed methods process evaluation was conducted alongside the implementation of the follow up program. Quantitative and qualitative data were collected across the evaluation domains: reach, dose, fidelity, context and sustainability and clinical data of program participants (patients); semi-structured interviews with staff delivering the program and patients and caregivers who had participated in the program and direct observations (by researchers) of the program delivery and dataDescriptive statistics and thematic analysis were applied to quantitative and qualitative data respectively.Results:274 major trauma patients (ISS ≥ 12) were eligible for follow up. A response rate of over 75% was achieved at both follow -up timepoints, with nurses responsible for the majority of calls. Limited time and competing clinical demands were identified as barriers to the timely completion of the calls, although over 75% of calls were completed within the designated timeframe. Staff and patients valued the pre-existing trauma service/patient relationship, and this facilitated program implementation. Clinicians were motivated to evaluate their patient’s recovery, whilst patients felt ‘cared for’ and ‘not forgotten’ post-hospital discharge. Teamwork and leadership were highly valued by the clinical staff throughout the implementation period as ongoing source of motivation and support. Although primarily designed as a data collection activity, staff spontaneously developed the program to incorporate clinical follow up processes by providing guidance, advice and referrals to patients who indicated ongoing issues such as pain or emotional problems.Conclusion: Telephone follow up within a clinical trauma service team is feasible, accepted by staff and valued by patients and families. Despite time constraints, the successful implementation of this program is reliant on existing clinical/patient relationships, staff teamwork and leadership support.