bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry
Authors: Rossi Rosanna , Molina Sara , Mereuta Oana Madalina , Douglas Andrew , Fitzgerald Seán , Tierney Ciara , Pandit Abhay , Brennan Paul , Power Sarah , O’Hare Alan , Gilvarry Michael , McCarthy Ray , Magoufis Georgios , Tsivgoulis Georgios , Nagy András , Vadász Ágnes , Jood Katarina , Redfors Petra , Nordanstig Annika , Ceder Erik , Dunker Dennis , Carlqvist Jeanette , Psychogios Klearchos , Szikora István , Tatlisumak Turgut , Rentzos Alexandros , Thornton John , Doyle Karen M. 
Published: August 2021

Abstract
Background and purpose
There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT on size and histological composition of the clots retrieved from patients undergoing bridging-therapy or MT alone.

Methods
We collected mechanically extracted thrombi from 1000 acute ischemic stroke (AIS) patients included in RESTORE registry. Patients were grouped according to the administration (or not) of IVT before thrombectomy. Gross photos of each clot were taken and Extracted Clot Area (ECA) was measured using ImageJ software. Martius Scarlett Blue stain was used to characterize the main histological clot components [red blood cells (RBCs), fibrin (FIB), platelets/other (PTL)] and Orbit Image Analysis was used for quantification. Additionally, we calculated the area of each main component by multiplying the component percent by ECA. Chi-squared and Kruskal–Wallis tests were used for statistical analysis.

Results
451 patients (45%) were treated with bridging-therapy while 549 (55%) underwent MT alone. When considering only percent histological composition, we did not find any difference in RBC% (P = 0.895), FIB% (P = 0.458) and PTL% (P = 0.905). However, bridging-therapy clots were significantly smaller than MT-alone clots [32.7 (14.8–64.9) versus 36.8 (20.1–79.8) mm2, N = 1000, H1 = 7.679, P = 0.006*]. A further analysis expressing components per clot area showed that clots retrieved from bridging-therapy cases contained less RBCs [13.25 (4.29–32.06) versus 14.97 (4.93–39.80) mm2, H1 = 3.637, P = 0.056] and significantly less fibrin [9.10 (4.62–17.98) versus 10.54 (5.57–22.48) mm2, H1 = 7.920, P = 0.005*] and platelets/other [5.04 (2.26–11.32) versus 6.54 (2.94–13.79) mm2, H1 = 9.380, P = 0.002*] than MT-alone clots.

Conclusions
Our results suggest that previous IVT administration significantly reduces thrombus size, proportionally releasing all the main histological components.
Threshold Phenomena for Random Cones
Authors: Hug Daniel , Schneider Rolf 
Published: August 2021

AbstractWe consider an even probability distribution on the d-dimensional Euclidean space with the property that it assigns measure zero to any hyperplane through the origin. Given N independent random vectors with this distribution, under the condition that they do not positively span the whole space, the positive hull of these vectors is a random polyhedral cone (and its intersection with the unit sphere is a random spherical polytope). It was first studied by Cover and Efron. We consider the expected face numbers of these random cones and describe a threshold phenomenon when the dimension d and the number N of random vectors tend to infinity. In a similar way we treat the solid angle, and more generally the Grassmann angles. We further consider the expected numbers of k-faces and of Grassmann angles of index $$d-k$$

d
-
k

when also k tends to infinity.
Genetic recombination as a generalised gradient flow
Authors: Alberti Frederic 
Published: August 2021

AbstractIt is well known that the classical recombination equation for two parent individuals is equivalent to the law of mass action of a strongly reversible chemical reaction network, and can thus be reformulated as a generalised gradient system. Here, this is generalised to the case of an arbitrary number of parents. Furthermore, the gradient structure of the backward-time partitioning process is investigated.
Microsurgical management of midbrain cavernous malformations: does lesion depth influence the outcome?
Authors: Huang Caiquan , Bertalanffy Helmut , Kar Souvik , Tsuji Yoshihito 
Published: August 2021

AbstractBackgroundThe purpose of this study was to clarify whether the intrinsic depth of midbrain cavernous malformations (MCMs) influenced the surgical outcome.MethodsThe authors conducted a retrospective study of 76 consecutive patients who underwent microsurgical resection of a MCM. The vascular lesions were categorized into 4 distinct groups based on how these lesions had altered the brainstem surface. Additionally, it was verified whether the actual aspect of the brainstem surface could be predicted only by evaluating the pertinent preoperative MRI slices. Clinical outcome was assessed by determining the modified Rankin Scale Score (mRS) before and after surgery.ResultsTwenty-three MCMs (30.3%) were located deeply within the midbrain. The overlying midbrain surface appeared to be normal (groupnl). In 33 patients (43.4%), the midbrain surface showed only a yellowish discoloration (groupyw). In another 14 individuals (18.4%), the midbrain surface was distorted by the underlying MCM and bulging out while the vascular lesion still remained covered by a thin parenchymal layer (groupbg). In the smallest group comprising 6 patients (7.9%), the exophytic MCM had disrupted the midbrain surface and was clearly visible at microsurgical exposure (groupex). The mean mRS decreased in the group nl from 1.43 preoperatively to 0.61 at follow-up.ConclusionThis study demonstrates in a large patient population that a deep intrinsic MCM location is not necessarily associated with an unfavorable clinical outcome after microsurgical lesionectomy. Predicting the aspect of the midbrain surface by evaluating preoperative MR images alone was not sufficiently reliable.
Estimating the additional costs of living with a disability in the United Kingdom between 2013 and 2016
Authors: Schuelke Lukas , Munford Luke , Morciano Marcello 
Published: August 2021

AbstractIn the United Kingdom, more than 20% of the population live with a disability. Past evidence shows that being disabled is associated with functional limitations that often cause social exclusion and poverty. Therefore, it is necessary to analyse the connection between disability and poverty. This paper examines whether households with disabled members face extra costs of living to attain the same standard of living as their peers without disabled members. The modelling framework is based on the standard of living approach which estimates the extra income required to close the gap between households with and without disabled members. We apply an ordered logit regression to data from the Family Resources Survey between 2013 and 2016 to analyse the relationship between standard of living, income, and disability, conditional on other explanatory variables. We find that households with disabled members face considerable extra costs that go beyond the transfer payment of the government. The average household with disabled members saw their weekly extra costs continually increase from £293 in 2013 to £326 in 2016 [2020 prices]. Therefore, the government needs to adjust welfare policies to address the problem of extra costs faced by households with disabled members.
Sectoral effects of the Japan-EU Economic Partnership Agreement for the European Union countries
Authors: Górska Rumiana 
Published: August 2021

AbstractThis paper assesses the economic impact of the Japan-EU Economic Partnership Agreement (JEEPA) on all EU member states as well as Japan. The novelty of this study is that it refers to all EU countries and provides an overview of the expected output effects of JEEPA for all member states in a detailed sectoral breakdown. This impact is investigated using the Computable General Equilibrium (CGE) framework. Calculations revealed that economic returns from JEEPA vary among the EU countries. Some of the more highly developed EU countries will experience beneficial effects from tariff reductions to a greater extent than others, while some of the newer, less-developed EU members will experience losses, caused by the lower competitiveness of these countries. Beneficial effects in the EU countries are expected mainly in the primary sector industries like meat and animal products, leather, grains, and crops; while in Japan, economic gains are expected in the motor vehicle and transport equipment industries. Despite the overall optimism accompanying the signing of the JEEPA, it is worth paying attention to the sectors that are expected to shrink as a result.
Using flower strips to promote green lacewings to control cabbage insect pests
Authors: Alcalá Herrera Rafael , Cotes Belén , Agustí Nuria , Tasin Marco , Porcel Mario 
Published: August 2021

AbstractHabitat management improves biological control by increasing the abundance and fitness of natural enemies through the provision of floral resources along field edges or between crops. Among the natural enemies reliant on flower resources, green lacewings often stand out due to their abundance, predation capacity and polyphagy. We evaluated the impact of tailored flower strips on the enhancement of natural enemies, especially green lacewings, in three organic cabbage (Brassica oleracea) farms in Southern Sweden. Insects were sampled from the flower strips, and cabbage pests and predators were visually recorded in the crop. In a laboratory assay, the pollen feeding preferences of Chrysoperla carnea (Stephens, 1836) were evaluated in a dual-choice test. The pollen consumed by the Chrysopidae was extracted from laboratory and field specimens, then quantified and identified. Flower strips were found to attract predators and parasitoids, whose abundance increased as flowers bloomed. Cabbage plants next to the flower strips showed lower pest infestation as compared to cabbage plant control, although no significant differences were observed in the number of predators. Chrysopidae used flower strips as feeding, reproduction and shelter sites and mainly consumed pollen from Phacelia tanacetifolia Benth. Under laboratory conditions, C. carnea showed a preference for P. tanacetifolia and Coriandrum sativum L. pollen over Borago officinalis L. and Fagopyrum esculentum Moench. We show that tailored flower strips could be an efficient tool for enhancing beneficial arthropods and should be considered in integrated pest management for cabbage crops.
The value of values-based supply chains: farmer perspective
Authors: Peterson Hikaru Hanawa , Feenstra Gail , Ostrom Marcia , Tanaka Keiko , Brekken Christy Anderson , Engelskirchen Gwenael 
Published: August 2021

AbstractIn the last few decades, the emergence of mid-scale, intermediated marketing channels that fall between commodity and direct markets has attracted growing interest from scholars for their potential to preserve small and mid-sized farms while scaling up alternative agrifood sourcing. When such mid-scale supply chains are formed among multiple business partners with shared ethics or values related to the qualities of the food and the business relationships along the supply chain, they may be termed “values-based supply chains (VBSCs).” Most of the research on VBSCs to date has relied primarily on a case study approach that investigates the performance of VBSCs from the perspective of VBSC founders or leaders. In contrast, this research seeks out the perspectives of farmers who participate in VBSCs. A nationwide farmer survey conducted in 2017 offers original insights on farmer motivations for participating in VBSCs and how they are being used by farmers relative to other marketing channels. We find that VBSCs serve farms of all sizes. Overall, smaller farms were more likely to market a higher percentage of overall sales through their VBSC and more likely to rank their VBSC as one of the top three marketing channels in their portfolio. But it was the larger farms that were more likely to perceive VBSC-specific benefits. Our findings confirm that while there is a limited volume of product that such regional supply chains can currently handle, farmers view VBSCs as a valuable marketing option that aligns with their own values and preserves their product’s identity.
Sinus node sparing novel hybrid approach for treatment of inappropriate sinus tachycardia/postural sinus tachycardia: multicenter experience
Authors: de Asmundis Carlo , Chierchia Gian-Battista , Lakkireddy Dhanunjaya , Romeya Ahmed , Okum Eric , Gandhi Gaurang , Sieira Juan , Vloka Margot , Jones Stephen D. , Shah Hemal , Winner Marshall , Patel Dilesh , Whalen S. Patrick , Beaty Elijah H. , Kincaid Edward Hal , Lee Anson , Brodt Chad , Taylor Benadict J. , Colombowala Ilyas , Romano Matthew , Morady Fred , Ströker Erwin , Overeinder Ingrid , Bala Gezim , Van Meeteren Justin , Krauthammer Yoaav , Koerber Scott , Shults Christian , Thomaides Athanasios , Badhwar Nitish , Gopinathannair Rakesh , Shah Alap , Tummala Rangarao , Bello David , Hoff Steve , Almorad Alexandre , Frazier Kenneth , Brugada Pedro , La Meir Mark 
Published: August 2021

Abstract
Background
The ideal treatment of inappropriate sinus tachycardia (IST) and postural orthostatic tachycardia syndrome (POTS) still needs to be defined. Medical treatments yield suboptimal results. Endocardial catheter ablation of the sinus node (SN) may risk phrenic nerve damage and open-heart surgery may be accompanied by unjustified invasive risks.

Methods
We describe our first multicenter experience of 255 consecutive patients (235 females, 25.94 ± 3.84 years) having undergone a novel SN sparing hybrid thoracoscopic ablation for drug-resistant IST (n = 204, 80%) or POTS (n = 51, 20%). As previously described, the SN was identified with 3D mapping. Surgery was performed through three 5-mm ports from the right side. A minimally invasive approach with a bipolar radiofrequency clamp was used to ablate targeted areas while sparing the SN region. The targeted areas included isolation of the superior and the inferior caval veins, and a crista terminalis line was made. All lines were interconnected.

Results
Normal sinus rhythm (SR) was restored in all patients at the end of the procedure. All patients discontinued medication during the follow-up. After a blanking period of 6 months, all patients presented stable SR. At a mean of 4.07 ± 1.8 years, normal SN reduction and chronotropic response to exercise were present. In the 51 patients initially diagnosed with POTS, no syncope occurred. During follow-up, pericarditis was the most common complication (121 patients: 47%), with complete resolution in all cases. Pneumothorax was observed in 5 patients (1.9%), only 3 (1.1%) required surgical drainage. Five patients (1.9%) required a dual-chamber pacemaker due to sinus arrest > 5 s.

Conclusions
Preliminary results of this multicenter experience with a novel SN sparing hybrid ablation of IST/POTS, using surgical thoracoscopic video-assisted epicardial ablation combined with simultaneous endocardial 3D mapping may prove to be an efficient and safe therapeutic option in patients with symptomatic drug-resistant IST and POTS. Importantly, in our study, all patients had a complete resolution of the symptoms and restored normal SN activity.
Contradictions and their manifestations in professional learning communities in mathematics
Authors: Harvey Frida , Nilsson Per 
Published: August 2021

AbstractProfessional learning communities (PLC) have increasingly attracted attention in research on teachers’ professional development. The aim of this study is to identify contradictions that can occur and be manifested in PLCs in mathematics. Identifying contradictions in PLCs are important, as the identification and resolution of contradictions are crucial to developing PLCs. We have conceptualized PLCs and contradictions within the Cultural Historical Activity Theory. Our data consist of two iterations of interviews with four teacher leader coaches with extensive experience of coaching teacher leaders of PLCs in mathematics. The study distinguishes 26 manifestations of contradictions, taking the overall forms of dilemmas and conflicts. Our results can be used in designing PLCs in mathematics: they can be used to make visible and increase participants’ awareness of contradictions involved in PLCs and thereby increase the possibility that the contradictions serve as sources of support rather than obstacles in the development of PLCs in mathematics.
On nondegenerate M-stationary points for sparsity constrained nonlinear optimization
Authors: Lämmel S. , Shikhman V. 
Published: August 2021

AbstractWe study sparsity constrained nonlinear optimization (SCNO) from a topological point of view. Special focus will be on M-stationary points from Burdakov et al. (SIAM J Optim 26:397–425, 2016), also introduced as$$N^C$$NC-stationary points in Pan et al. (J Oper Res Soc China 3:421–439, 2015). We introduce nondegenerate M-stationary points and define their M-index. We show that all M-stationary points are generically nondegenerate. In particular, the sparsity constraint is active at all local minimizers of a generic SCNO. Some relations to other stationarity concepts, such as S-stationarity, basic feasibility, and CW-minimality, are discussed in detail. By doing so, the issues of instability and degeneracy of points due to different stationarity concepts are highlighted. The concept of M-stationarity allows to adequately describe the global structure of SCNO along the lines of Morse theory. For that, we study topological changes of lower level sets while passing an M-stationary point. As novelty for SCNO, multiple cells of dimension equal to the M-index are needed to be attached. This intriguing fact is in strong contrast with other optimization problems considered before, where just one cell suffices. As a consequence, we derive a Morse relation for SCNO, which relates the numbers of local minimizers and M-stationary points of M-index equal to one. The appearance of such saddle points cannot be thus neglected from the perspective of global optimization. Due to the multiplicity phenomenon in cell-attachment, a saddle point may lead to more than two different local minimizers. We conclude that the relatively involved structure of saddle points is the source of well-known difficulty if solving SCNO to global optimality.
Quantitative analysis of a subgradient-type method for equilibrium problems
Authors: Pischke Nicholas , Kohlenbach Ulrich 
Published: August 2021

AbstractWe use techniques originating from the subdiscipline of mathematical logic called ‘proof mining’ to provide rates of metastability and—under a metric regularity assumption—rates of convergence for a subgradient-type algorithm solving the equilibrium problem in convex optimization over fixed-point sets of firmly nonexpansive mappings. The algorithm is due to H. Iiduka and I. Yamada who in 2009 gave a noneffective proof of its convergence. This case study illustrates the applicability of the logic-based abstract quantitative analysis of general forms of Fejér monotonicity as given by the second author in previous papers.
Feng Shui and the Demarcation Project
Authors: Fernandez-Beanato Damian 
Published: August 2021

AbstractThe vast majority of well-informed philosophers of science and scientists who are clearly (uncontroversially) scientists are able to extensionally differentiate between almost all scientific and non-scientific practices, disciplines, theories, attitudes, modes of procedure, etc., and do so or would do so in much the same way. This legitimately leads to the conclusion that the main problem of scientific demarcation has already, in a sense, been solved, although an explicative integrated account of that solution has not yet been given. Doing so is the goal of the project proposed in Fernandez-Beanato (Journal for General Philosophy of Science51(3):375–391, 2020b). To advance toward the solution of the scientific demarcation problem, this article executes part of that project: a first step for scientific demarcation is the composition of a broad “list” (set) of accepted characteristics, conditions, or properties of science, or indicators of scientificity (most of them, by themselves, unnecessary and insufficient) which might be collectively used to establish a demarcation between those theories, cognitive fields, practices, etc. which are scientific and those which are not. This article deals with feng shui as a clear case of a non-science. It defines feng shui and then lists properties of science that feng shui possesses and properties of science that it lacks. This article then shows that the proposed demarcatory list demarcates feng shui as non-scientific, in agreement with the current philosophical and scientific consensus.
Sustainable mechanochemical synthesis of β-cyclodextrin polymers by twin screw extrusion
Authors: Rubin Pedrazzo Alberto , Trotta Francesco , Hoti Gjylije , Cesano Federico , Zanetti Marco 
Published: August 2021

AbstractCyclodextrin nanosponges (CD-NS) are cross-linked cyclodextrin polymers characterized by a nanostructured three-dimensional network. CD-NSs in the last years found many different applications in the pharmaceutical field for the controlled release of drugs and for the absorption of undesired substances from physiological media, food, and wastewater. Most of CD-NS syntheses involve the solubilization of the chosen CD in closed batch, using a suitable organic polar aprotic liquid, which may affect potential environmental or biomedical applications. Since the research is now moving towards more sustainable approaches, new and greener syntheses of CD-NS are now being developed. Here, it is reported a new eco-friendly and efficient synthesis of nanosponges through mechanochemistry. Mechanochemistry involves the application of mechanical forces to drive and control chemical reactions by transferring energy to chemical bonds. The mechanochemical approach involves the use of a twin-screw extruder (TSE) as a chemical reactor: TSE are capable of fine temperature control and, furthermore, TS Extrusion is a continuous process and not a batch process. Among the many available CD-NS syntheses, we tested our solvent-free approach on a β-CD/citric acid (CA) system. Moreover, using TSE, the same polymer was obtained in a considerably shorter time. The so obtained NSs were used for the adsorption and removal of probe molecules, in comparison with NSs prepared by cross-linking β-CD with CA in batch.
Graphical Abstract
Quantitative 3D imaging of partially saturated granular materials under uniaxial compression
Authors: Milatz Marius , Hüsener Nicole , Andò Edward , Viggiani Gioacchino , Grabe Jürgen 
Published: August 2021

AbstractGauging the mechanical effect of partial saturation in granular materials is experimentally challenging due to the very low suctions resulting from large pores. To this end, a uniaxial (zero radial stress) compression test may be preferable to a triaxial one where confining pressure and membrane effects may erase the contribution of this small suction; however, volume changes are challenging to measure. This work resolves this limitation by using X-ray imaging during in situ uniaxial compression tests on Hamburg Sand and glass beads at three different initial water contents, allowing a suction-dependent dilation to be brought to the light. The acquired tomography volumes also allow the development of air–water and solid–water interfacial areas, water clusters and local strain fields to be measured at the grain scale. These measurements are used to characterise pertinent micro-scale quantities during shearing and to relate them to the measured macroscopic response. The new and well-controlled data acquired during this experimental campaign are hopefully a useful contribution to the modelling efforts—to this end they are shared with the community.