bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief early adolescent multi-family therapy (BEAM) trial for anorexia nervosa: a feasibility randomized controlled trial protocol
Authors: Baudinet Julian , Eisler Ivan , Simic Mima , Schmidt Ulrike 
Published: June 2021

AbstractIntroductionMulti-family therapy (MFT) is a recommended treatment for adolescent anorexia nervosa internationally. Despite recent significant advances in single-family therapy, the evidence base for MFT remains relatively small. Several individual and family factors have been associated with poorer outcomes in single-family therapy, many of which may be addressed or ameliorated by MFT if delivered early in treatment. This trial aims to determine the feasibility and acceptability of adding a five-day multi-family therapy group to the early stages of family therapy for anorexia nervosa. Secondary objectives are to explore effect size changes in key individual and family factors across treatment.MethodsThis feasibility trial will use a randomised controlled design. Sixty adolescents (age 10–17 inclusive) with anorexia nervosa or atypical anorexia nervosa and their parents will be recruited from a community-based specialist eating disorder service in London, UK. Participants will be randomly allocated to receive six months of eating disorder focussed family therapy with a five-day MFT group (experimental group) or without (control group). Block randomisation will be conducted by the King’s Clinical Trials Unit and researchers will be blind to participants’ intervention allocation. Feasibility, acceptability and secondary outcomes measures will be collected at baseline, post-MFT, end of treatment, six-month and 12-month follow-up. Feasibility and acceptability will be assessed according to trial sign-up rates, retention, measure completion rates and satisfaction. Secondary outcomes include physical health improvements, changes in psychiatric symptoms, emotion regulation and reflective function capacity, expressed emotion, parental difficulties and therapeutic alliance. Descriptive data and exploration analysis of trends and effect sizes will be reported upon at trial completion.DiscussionThe five-day MFT program developed for this study is novel, brief and more accessible than previous MFT models. The inclusion of a data collection point during treatment and follow-up will allow for an investigation of trends during and after treatment. This will allow exploration and comparison of future potential mediators and moderators of MFT and FT-AN outcomes and how these may differ between treatments.Trial registrationISRCTN registry;ISRCTN93437752, on 27 January 2021.
Immunotherapy in endometrial cancer: rationale, practice and perspectives
Authors: Cao Wenyu , Ma Xinyue , Fischer Jean Victoria , Sun Chenggong , Kong Beihua , Zhang Qing 
Published: June 2021

AbstractTumor immunotherapy has attracted more and more attention nowadays, and multiple clinical trials have confirmed its effect in a variety of solid tumors. Immune checkpoint inhibitors (ICIs), cancer vaccines, adoptive cell transfer (ACT), and lymphocyte-promoting cytokines are the main immunotherapy methods. Endometrial cancer (EC) is one of the most frequent tumors in women and the prognosis of recurrent or metastatic EC is poor. Since molecular classification has been applied to EC, immunotherapy for different EC subtypes (especially POLE and MSI-H) has gradually attracted attention. In this review, we focus on the expression and molecular basis of the main biomarkers in the immunotherapy of EC firstly, as well as their clinical application significance and limitations. Blocking tumor immune checkpoints is one of the most effective strategies for cancer treatment in recent years, and has now become the focus in the field of tumor research and treatment. We summarized clinical date of planned and ongoing clinical trials and introduced other common immunotherapy methods in EC, such as cancer vaccine and ACT. Hormone aberrations, metabolic syndrome (MetS) and p53 mutant and that affect the immunotherapy of endometrial cancer will also be discussed in this review.
The use of Robinia pseudoacacia L fruit extract as a green corrosion inhibitor in the protection of copper-based objects
Authors: Pourzarghan Vahid , Fazeli-Nasab Bahman 
Published: June 2021

Abstract
The most important inhibitors used in bronze disease are BTA and AMT. While these inhibitors control corrosion, they are toxic and cancerous. In this study, the acacia fruit extract (200 ppm to 1800 ppm) was used to the prevention of corrosion inhibition of bronze alloy in corrosive sodium chloride solution 0.5 M, for 4 weeks consecutively. The Bronze alloy used in this research, was made based on the same percentage as the ancient alloys (Cu-10Sn). IE% was used to obtain the inhibitory efficiency percentage and Rp can be calculated from the resistance of polarization. SEM–EDX was used to evaluate the surfaces of alloy as well as inhibitory. The experiment was conducted in split plot design in time based on the RCD in four replications. ANOVA was performed and comparison of means square using Duncan's multiple range test at one percent probability level. The highest rate of corrosion inhibition (93.5%) was obtained at a concentration of 1800 ppm with an increase in the concentration of the extract, corrosion inhibition also increased, i.e., more bronze was prevented from burning. Also, the highest corrosion inhibitory activity of Acacia extract (79.66) was in the second week and with increasing duration, this effect has decreased. EDX analysis of the control sample matrix showed that the amount of chlorine was 8.47%wt, while in the presence of corrosive sodium chloride solution, after 4 weeks, the amount of chlorine detected was 3.20%wt. According to the morphology (needle and rhombus) of these corrosion products based on the SEM images, it can be said, they are the type of atacamite and paratacamite. They have caused bronze disease in historical bronze works. The green inhibitor of Acacia fruit aqueous extract can play an effective role in inhibiting corrosion of bronze, but at higher concentrations, it became fungal, which can reduce the role of Acacia fruit aqueous extract and even ineffective. To get better performance of green inhibitors, more tests need to be done to improve and optimize.
Perception of the health surveillance users on the health electronic surveillance network (HESN), Saudi Arabia, 2016
Authors: Almayahi Zayid K. , Alswaidi Fahad , Alzahrani Abdullah 
Published: June 2021

AbstractBackgroundThe established aim of the Saudi Health Electronic Surveillance Network (HESN) is to support the prevention and control of different health events, and to facilitate the delivery of other public health programs. This study aims to evaluate the perceptions of active HESN users regarding its general performance through five major components: practicability, design, data and communication, technical support, and general impression.MethodsA cross-sectional study was conducted in 2016 using a sample of active HESN users. Out of 1535 active users, 700 were randomly selected. A predesigned electronic questionnaire was sent to each participant via email which was completed by 485 participants. Different composite scores were calculated and compared to the sociodemographic and other technical variables.ResultsThe mean age of the participants was 36.92 ± 9.12 (24–65 years), and 57.8% of the sample were male. Riyadh and the KSA’s eastern province represented the highest two regions of participation, at (18.4%) and (14.2%) participants, respectively. About 70.8% were generally satisfied with HESN, while 86.6%% believed that it is better than the traditional paper-work system. Participants who used to work more frequently expressed more level of satisfaction compared to those with minimal use per week or month (P≤ 0.001). Internet speed displayed a significant association with the general level of satisfaction with HESN (P< 0.001). Additionally, users who accessed HESN with the Google Chrome browser displayed higher levels of satisfaction when compared to users who relied on other browsers (P= 0.003).ConclusionPresently, the level of user satisfaction with HESN is reasonable. However, to achieve optimal outcomes for HESN usage, improvements should be considered.
Microbiological quality of non-sterile pharmaceuticals in Egypt
Authors: Salem Nourhan Mahrous Ahmed , Elbarrawy Mohamed Abbas , Azzam Nashwa Fawzy Abd El Moez 
Published: June 2021

AbstractBackgroundThe context and purpose of the study are as follows: Drug-borne infections may arise from non-adherence to strict microbiological quality of pharmaceuticals products. Moreover, presence of exceeding levels of microorganisms in non-sterile pharmaceuticals may lead to change of their organoleptic characteristics and loss of effectiveness. The aim of the study is to evaluate the microbiological quality of commonly used non-sterile pharmaceuticals in Alexandria, Egypt.ResultsAverage microbiological quality of the studied products, where 17.03% and 19.23 % of samples had exceeded the maximum acceptable limit of TAMC and TYMC, respectively. NoE.coliwas isolated from oral products. None ofS.aureusnorP.aeruginosawere isolated from topical products. Bacterial growth was recovered from 19 (10.44%) of the studied 182 samples, fourBacillusspp. had been recovered from topical products, twoP.aeruginosaisolates were recovered from tablets and other two were isolated from syrups dosage forms. Other isolates werePseudomonas stutzeri,Stenotrophomonas maltophilia,Acinetobacter Achromobacter denitrificans,Ochrobactrum anthropicandAeromonas salmonicida.ConclusionAverage microbiological quality of the tested pharmaceuticals used in Alexandria.
Patterns and Predictors of Oral Anticancer Agent Use in Diverse Patients With Metastatic Renal Cell Carcinoma
Authors: Wheeler Stephanie B. , Spees Lisa P. , Jackson Bradford E. , Baggett Christopher D. , Wilson Lauren E. , Greiner Melissa A. , Kaye Deborah R. , Zhang Tian , George Daniel , Scales Charles D. , Pritchard Jessica E. , Dinan Michaela A. 
Published: June 2021

PURPOSE: Availability of targeted oral anticancer agents (OAAs) has transformed care for patients with metastatic renal cell carcinoma (mRCC). Our objective was to identify patterns and predictors of OAA use within 12 months after mRCC was detected to understand real-world adoption of OAAs. METHODS: We used a novel, North Carolina cancer registry–linked multipayer claims data resource to examine patterns of use of five oral therapies among patients with mRCC diagnosed in 2006-2015, with claims through 2016. Patients were required to have 12 months of continuous enrollment before metastatic index date. Log-Poisson models estimated unadjusted and adjusted risk ratios (RRs) for associations between patient characteristics and OAA use. In sensitivity analyses, we used a competing risk framework to estimate adjusted risk differences in OAA use. RESULTS: Our population-based study of 713 patients demonstrated low (37%) OAA use during the first year after metastatic index date among both publicly and privately insured patients, with shifting patterns of use consistent with regulatory approvals over time. Compared with patients age 18-49 years, patients age 70-74 years were half likely to use OAAs (95% confidence limit [CL], 0.34 to 0.78) and patients age 80+ years were 71% less likely to use OAAs (95% CL, 0.17 to 0.50). Patients with two comorbidities (RR, 0.73; 95% CL, 0.55 to 0.98) and those with 3+ comorbidities (RR, 0.68; 95% CL, 0.50 to 0.91) were less likely to receive OAA than those without comorbidities. Patients with higher frailty also had lower OAA utilization (RR, 0.67; 95% CL, 0.52 to 0.85). CONCLUSION: These findings suggest a need to better understand the system-level and provider-level drivers of OAA underuse, as well as OAA adherence and associated survival.
Geography, Genre, and Narrative in Kipling's Kim
Authors: Laskin Emily 
Published: June 2021

Abstract
This article examines Kipling's 1901 novel Kim in light of the period's contemporary geopolitical events, arguing that the novel imagines both the end of the British Empire and a utopian state in which empire is static and eternal. The essay uncovers a parallel between the geographic regions on India's periphery, toward which the novel's action drives but which it never ultimately reaches, and two “developmental genres,” the picaresque and the bildungsroman, which the novel holds in tension. It argues further that whereas earlier studies of Kim and the bildungsroman have explained Kim's thwarted temporality as a novel about a period newly unmoored from the stabilizing concept of the nation-state, they do not account for the politicized space of Kipling's South Asia. This article shows that just as temporal development was becoming more open-ended and abstract, spatial development in the non-European world was becoming increasingly circumscribed. Kim therefore requires not just a youthful hero and a deferred Bildung but also an unreachable region—Central Asia, to India's north—and a thwarted picaresque narrative in order to represent the newly burgeoning globalized order.
Differentiation of cystic lesions in the jaw by conventional magnetic resonance imaging and diffusion-weighted imaging
Authors: Wamasing Natnicha , Watanabe Hiroshi , Sakamoto Junichiro , Tomisato Hiroshi , Kurabayashi Tohru 
Published: June 2021

Objectives: This study aimed to determine the discrimination power of apparent diffusion coefficient (ADC) for cystic lesions in the jaw using MRI. Methods: We selected 127 cystic lesions, comprising dentigerous cysts (DCs), odontogenic keratocysts (OKCs), and unicystic ameloblastomas (UABs), from our MRI database examined by 3T MRI, including diffusion-weighted imaging sequences, and we reviewed their imaging characteristics. We attempted to discriminate the three types of lesions by ADC values with receiver operator characteristic analysis; however, satisfactory results were not obtained for differentiation between DC and OKC. Therefore, we performed a decision tree analysis. Results: The imaging characteristics of the lesions were significantly different according to Fisher’s exact test, except for differences in sex. The ADC values statistically discriminated the lesions of DC and UAB, OKC and UAB, but not DC and OKC. Thus, differentiation was performed by a decision tree for DC and OKC by evaluating the following points: the attached tooth condition, signal intensity on the T1 weighted image (T1SI), ADC value, and the cyst site. However, cases showing hypo- or isointense T1SI with an ADC value under 1.168 × 10–3 mm2/s were difficult to differentiate. Conclusion: The ADC value helped distinguish UAB from both DC and OKC, but not DC from OKC. However, the decision tree based on ADC value, tooth contact status, and T1SI helped differentiate DC and OKC to some extent.
(Des)informação nos serviços de saúde em tempos de pandemia da Covid-19: uma questão ética e uma requisição enviesada ao trabalho de assistentes sociais
Authors: De Matos Maurílio Castro 
Published: June 2021

O artigo reflete sobre os desafios éticos que a pandemia da Covid-19 evidencia. No contexto de uma doença provocada por um vírus, que ainda não possui cura e nem vacina para todas as pessoas, a luta pelo acesso aos serviços de saúde e direito a vida é uma questão ética. No trabalho nos serviços hospitalares, nos tempos da pandemia, têm surgido requisições de cunho administrativo e burocrático para o trabalho de Assistentes Sociais, que gravitam em torno do direito a informação. Tal questão, ainda que não seja na sua maioria, de competência desses profissionais, expressa uma requisição ética posta para o trabalho coletivo em saúde. Palavras-Chave: covid-19; saúde, serviço social; ética; informação.
Aerosol and Gas Phase Concentrations from an Adapted Annular Denuder System in a Broiler Housing Facility
Authors: Spencer Jennifer L. , Osborne Vern , Van Heyst Bill 
Published: June 2021

HighlightsAn adapted annular denuder system (ADS) was implemented in a broiler facility to measure secondary aerosols.Results show that secondary aerosols were not always associated with ammonium or ammonia.Chloride aerosols were significant in comparison to other species and were present at consistent concentrations.This study concludes that the chloride source was the feed in the feeding pans.Abstract. Fine particulate matter (PM2.5) is present in animal housing facilities from both primary and secondary sources. Measuring secondary aerosols in harsh environments with high gas and particulate concentrations, such as poultry housing facilities, is an ongoing challenge. This study presents the results from the implementation of an adapted annular denuder system (ADS) used to measure secondary PM2.5 from inside a broiler facility in Ontario, Canada. Results from this work show that secondary aerosols formed the majority of total PM2.5 during the early portion of the growth cycle. It was further determined that the ion balance between ammonium and anions was not consistent, leading to the conclusion that a significant portion of the aerosol species are associated with a previously unidentified source that is not necessarily due to secondary reactions. Keywords: Ammonia, Annular denuder system, Particulate matter, Poultry, Secondary aerosols.
F-mode ultraviolet photoacoustic remote sensing for label-free virtual H&E histopathology using a single excitation wavelength
Authors: Kedarisetti Pradyumna , Restall Brendon S. , Haven Nathaniel J. M. , Martell Matthew T. , Cikaluk Brendyn D. , Deschenes Jean , Zemp Roger J. 
Published: June 2021

Photoacoustic remote sensing (PARS) is a novel all-optical imaging modality that allows for non-contact detection of initial photoacoustic pressures. Using 266-nm excitation pulses, ultraviolet PARS (UV-PARS) has previously demonstrated imaging contrast for cell nuclei in histological samples with

<

400

n
m

resolution. In prior PARS-based imaging schemes, the signal amplitude at an interrogation point was determined by the maximum deflection from the DC scattering signal in response to a pulsed excitation. This method, however, does not take into consideration additional information encoded in the frequency domain of the recorded PARS signals. Here, we present a frequency domain technique called F-mode PARS that can be used to generate images with nuclear and cytoplasmic enhanced contrast, enabling label-free virtual hematoxylin-and-eosin-like microscopy, using only a single excitation wavelength. With F-mode processing, we have been able to demonstrate contrast-to-noise ratios of up to 38 dB between cell nuclei and surrounding cytoplasm, which represents up to a 25-dB improvement over previous implementations of UV-PARS systems.
Hybrid-integrated high-performance microwave photonic filter with switchable response
Authors: Tao Yuansheng , Shu Haowen , Wang Xingjun , Jin Ming , Tao Zihan , Yang Fenghe , Shi Jingbo , Qin Jun 
Published: June 2021

The integrated microwave photonic filter (MPF), as a compelling candidate for next-generation radio-frequency (RF) applications, has been widely investigated for decades. However, most integrated MPFs reported thus far have merely incorporated passive photonic components onto a chip-scale platform, while all necessary active devices are still bulk and discrete. Though few attempts to higher photonic integration of MPFs have been executed, the achieved filtering performances are fairly limited, which impedes the pathway to practical deployments. Here, we demonstrate, for the first time to our knowledge, an all-integrated MPF combined with high filtering performances, through hybrid integration of an InP chip-based laser and a monolithic silicon photonic circuit consisting of a dual-drive Mach–Zehnder modulator, a high-

Q

ring resonator, and a photodetector. This integrated MPF exhibits a high spectral resolution as narrow as 360 MHz, a wide-frequency tunable range covering the S-band to K-band (3 to 25 GHz), and a large rejection ratio of

>
40

dB

. Moreover, the filtering response can be agilely switched between the bandpass and band-stop function with a transient respond time (

∼
48

μs

). Compared with previous MPFs in a similar integration level, the obtained spectral resolution in this work is dramatically improved by nearly one order of magnitude, while the valid frequency tunable range is broadened more than twice, which can satisfy the essential filtering requirements in actual RF systems. As a paradigm demonstration oriented to real-world scenarios, high-resolution RF filtering of realistic microwave signals aiming for interference rejection and channel selection is performed. Our work points out a feasible route to a miniaturized, high-performance, and cost-effective MPF leveraging hybrid integration approach, thus enabling a range of RF applications from wireless communication to radar toward the higher-frequency region, more compact size, and lower power consumption.
Soil-transmitted helminth infection, anemia, and malnutrition among preschool-age children in Nangapanda subdistrict, Indonesia
Authors: Djuardi Yenny , Lazarus Gilbert , Stefanie Difa , Fahmida Umi , Ariawan Iwan , Supali Taniawati 
Published: June 2021

BackgroundSoil-transmitted helminth (STH) infections are still prevalent in Indonesia, with roughly one-third of infected population being preschool-age children (PSC), which are generally at higher risk of morbidity such as malnutrition and anemia. This study aimed to investigate the association of STH infections with nutritional status and anemia among PSC in Nangapanda subdistrict, Ende, East Nusa Tenggara.MethodsA cross-sectional survey involving PSC ranging from 12 to 59 months old from Nangapanda subdistrict, Ende district, East Nusa Tenggara was performed. Socio-demographic, breastfeeding, and complementary feeding information was obtained from structured questionnaires, while nutritional and anemia status was determined from anthropometry and hemoglobin measurements, respectively. Anthropometric z-scores were calculated based on the World Health Organization 2006 standards and stool samples were examined using Kato-Katz method.ResultsA total of 393 PSC randomly selected from 22 villages were examined. The prevalence of underweight, stunting, wasting, and anemia were 33.1%, 40.2%, 17.1%, and 60.3%, respectively. STH infection, predominated byAscaris lumbricoides, was found in 160 (58.8%) PSC. Single STH infection, but not multiple infection, was independently associated with a lower risk of anemia (odds ratio [OR] 0.320, 95% confidence interval [CI]: 0.126–0.809, p = 0.016). Similar association with anemia was also found on mild STH infection (OR 0.318 [95% CI: 0.114–0.887], p = 0.029). On the other hand, younger children were found to have a higher risk of anemia and stunting. None of the examined variables were independently associated with underweight and wasting.ConclusionSTH infection as well as anemia and malnutrition were prevalent in this region. However in this study, current STH infections seemed to have minimal negative impact on children’s nutritional status.