bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zic Family Member 2 (ZIC2): a Potential Diagnostic and Prognostic Biomarker for Pan-Cancer
Authors: Lv Zhengtong , Qi Lin , Hu Xiheng , Mo Miao , Jiang Huichuan , Fan Benyi , Li Yuan 
Published: February 2021

Background: As a transcription factor, Zinc finger protein ZIC2 can interact with various DNAs and proteins. Current studies have shown that ZIC2 plays an oncogene role in various cancers. In this study, we systematically characterize the prevalence and predictive value of ZIC2 expression across multiple cancer types.Methods: We mined several public databases, including Oncomine, the Cancer Genome Atlas (TCGA), cBioPortal, Kaplan-Meier Plotter and PrognoScan to evaluated the differentially expressed ZIC2 between tumor samples and normal control samples in pan-cancner, and then explored the association between ZIC2 expression and patient survival, prognosis and clinicopathologic stage. We also analyzed the relationship between tumor mutation burden (TMB), microsatellite instability (MSI), tumor microenvironment, tumor- and immune-related genes and ZIC2 expression. Finally, we explored the potential signaling pathway mechanism through gene set enrichment analysis (GSEA).Results: ZIC2 expression was higher in most cancer tissues compared with adjacent normal tissues. High ZIC2 expression was associated with worse prognosis and a higher clinicopathologic stage. ZIC2 expression was strongly associated with the TMB, MSI, tumor microenvironment and tumor- and immune-related genes. The GSEA revealed that multiple tumor- and immune-related pathways were differentially enriched in ZIC2 high or low expression phenotype.Conclusion: ZIC2 expression may be a potential prognostic molecular biomarker of poor survival in pan-cancer and may act as an oncogene with a strong effect in the processes of tumorigenesis and progression.
SDL Index Predicts Stroke-Associated Pneumonia in Patients After Endovascular Therapy
Authors: Zhang Bowei , Zhao Wenbo , Wu Chuanjie , Wu Longfei , Hou Chengbei , Klomparens Kara , Ding Yuchuan , Li Chuanhui , Chen Jian , Duan Jiangang , Zhang Yunzhou , Chang Hong , Ji Xunming 
Published: February 2021

Objective: This study aimed to develop and validate a novel index to predict SAP for AIS patients who underwent endovascular treatment.Methods: A study was conducted in an advanced comprehensive stroke center from January 2013 to December 2019 aiming to develop and validate a novel index to predict SAP for AIS patients who underwent endovascular treatment. This cohort consisted of a total of 407 consecutively registered AIS patients who underwent endovascular therapy, which was divided into derivation and validation cohorts. Multiple blood parameters as well as demographic features, vascular risk factors, and clinical features were carefully evaluated in the derivation cohort. The independent predictors were obtained using multivariable logistic regression. The scoring system was generated based on the β-coefficients of each independent risk factor.Results: Ultimately, a novel predictive model: the SDL index (stroke history, dysphagia, lymphocyte count &lt; 1.00 × 103/μL) was developed. The SDL index showed good discrimination both in the derivation cohort (AUROC: 0.739, 95% confidence interval, 0.678–0.801) and the validation cohort (AUROC: 0.783, 95% confidence interval, 0.707–0.859). The SDL index was well-calibrated (Hosmer–Lemeshow test) in the derivation cohort (P = 0.389) and the validation cohort (P = 0.692). We therefore divided our population into low (SDL index = 0), medium (SDL index = 1), and high (SDL index ≥ 2) risk groups for SAP. The SDL index showed good discrimination when compared with two existing SAP prediction models.Conclusions: The SDL index is a novel feasible tool to predict SAP risk in acute ischemic stroke patients post endovascular treatment.
Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages
Authors: Wang Siyu , Rao Jiang , Yue Yingying , Xue Chen , Hu Guanjie , Qi Wenzhang , Ma Wenying , Ge Honglin , Zhang Fuquan , Zhang Xiangrong , Chen Jiu 
Published: February 2021

BackgroundSubjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI) are regarded to be at high risk of converting to Alzheimer’s disease (AD). Amplitude of low-frequency fluctuations (ALFF) can reflect functional deterioration while diffusion tensor imaging (DTI) is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands and white matter fiber integrity among normal controls (CN), SCD, naMCI, and aMCI groups. Correlation analyses were further utilized among paired DTI alteration, ALFF deterioration, and cognitive decline.ResultsFor ALFF calculation, ascended ALFF values were detected in the lingual gyrus (LING) and superior frontal gyrus (SFG) within SCD and naMCI patients, respectively. Descended ALFF values were presented mainly in the LING, SFG, middle frontal gyrus, and precuneus in aMCI patients compared to CN, SCD, and naMCI groups. For DTI analyses, white matter alterations were detected within the uncinate fasciculus (UF) in aMCI patients and within the superior longitudinal fasciculus (SLF) in naMCI patients. SCD patients presented alterations in both fasciculi. Correlation analyses revealed that the majority of these structural and functional alterations were associated with complicated cognitive decline. Besides, UF alterations were correlated with ALFF deterioration in the SFG within aMCI patients.ConclusionsSCD shares structurally and functionally deteriorative characteristics with aMCI and naMCI, and tends to convert to either of them. Furthermore, abnormalities in white matter fibers may be the structural basis of abnormal brain activation in preclinical AD stages. Combined together, it suggests that structural and functional integration may characterize the preclinical AD progression.
Disrupted Regional Homogeneity in Melancholic and Non-melancholic Major Depressive Disorder at Rest
Authors: Yan Meiqi , He Yuqiong , Cui Xilong , Liu Feng , Li Huabing , Huang Renzhi , Tang Yanqing , Chen Jindong , Zhao Jingping , Xie Guangrong , Guo Wenbin 
Published: February 2021

Background: Melancholic depression has been viewed as one severe subtype of major depressive disorder (MDD). However, it is unclear whether melancholic depression has distinct changes in brain imaging. We aimed to explore specific or distinctive alterations in melancholic MDD and whether the alterations could be used to separate melancholic MDD from non-melancholic MDD or healthy controls.Materials and Methods: Thirty-one outpatients with melancholic MDD and thirty-three outpatients with non-melancholic MDD and thirty-two age- and gender-matched healthy controls were recruited. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with the regional homogeneity (ReHo) and support vector machine (SVM) methods.Results: Melancholic MDD patients exhibited lower ReHo in the right superior occipital gyrus/middle occipital gyrus than non-melancholic MDD patients and healthy controls. Merely for non-melancholic MDD patients, decreased ReHo in the right middle frontal gyrus was negatively correlated with the total HRSD-17 scores. SVM analysis results showed that a combination of abnormal ReHo in the right fusiform gyrus/cerebellum Crus I and the right superior occipital gyrus/middle occipital gyrus exhibited the highest accuracy of 83.05% (49/59), with a sensitivity of 90.32% (28/31), and a specificity of 75.00% (21/28) for discriminating patients with melancholic MDD from patients with non-melancholic MDD. And a combination of abnormal ReHo in the right fusiform gyrus/cerebellum VI and left postcentral gyrus/precentral gyrus exhibited the highest accuracy of 98.41% (62/63), with a sensitivity of 96.77% (30/31), and a specificity of 100.00%(32/32) for separating patients with melancholic MDD from healthy controls.Conclusion: Our findings showed the distinctive ReHo pattern in patients with melancholic MDD and found brain area that may be associated with the pathophysiology of non-melancholic MDD. Potential imaging markers for discriminating melancholic MDD from non-melancholic MDD or healthy controls were reported.
Study on a conductive channel of a Pt/NiO/Pt ReRAM by bias application with/without a magnetic field
Authors: Koga Yuki , Hasegawa Tsuyoshi 
Published: February 2021

Abstract
Resistive random access memories (ReRAMs) have attracted much attention as a next-generation non-volatile memory. We focused on a NiO-based ReRAM in this study because it contains the magnetic element Ni. As-fabricated devices exhibit ideal memristive operation. When bias was swept in one polarity, the resistance decreased by repeating the bias sweeping. Conversely, by changing the polarity of the sweeping bias, the resistance gradually increased by repeating the bias sweeping. A steep increase in current was observed when continuing bias sweeping in the polarity that decreased the resistance. The resistance after that was lower than 12.9 kΩ, which suggests the formation of a Ni atom chain. Conductance quantization, with a unit of 2e
2/h, also suggested the said formation. When a magnetic field was applied, the unit of conductance quantization appeared to change from 2e
2/h to e
2/h.
Afectaciones ocupacionales y emocionales derivadas del aislamiento social en tiempos del Covid-19. Un estudio de casos
Authors: Hernández Vergel Viviana Karina , Prada Núñez Raúl , Hernández Suárez César Augusto 
Published: February 2021

Debido a la rapidez de propagación del Covid-19 en el mundo, muchos países han coincidido en el aislamiento social obligatorio como una estrategia para desacelerar el contagio. Por ello en Colombia se decretó el cierre de todo tipo de espacios en donde se congreguen las personas para evitar contagios masivos, ordenando el confinamiento obligatorio en los hogares. Esta investigación busca caracterizar los efectos derivados del aislamiento obligatorio en docentes y estudiantes del programa de Terapia Ocupacional de la Universidad de Santander – Cúcuta. Se adopta como enfoque metodológico el cuantitativo descriptivo transversal. Se diseña un instrumento propio fundamentado en unos ya conocidos, que fue validado por juicio de expertos y administrado a los informantes en su versión on-line. Los resultados evidencian que los docentes han sido más receptivos al cambio de rutinas y hábitos diarios, mientras que en los estudiantes se observa mayor resistencia.
Respecto a la distribución de los informantes en los diversos niveles de depresión, se pudo determinar que en los estudiantes se evidencia mayor afectación, aunque hay aspectos que son comunes en ambas poblaciones, como lo son la pérdida de sueño, el aumento del apetito, de sentimientos de tristeza, cansancio y concentración.
Analisis Pengaruh Karakteristik dan Tata Kelola Perusahaan terhadap Pengungkapan Tanggung Jawab Sosial Perusahaan di Indonesia
Authors: Kristina Sonia , Wati Erna 
Published: February 2021

The purpose of this research is set out to investigate and discuss the influence of characteristics and corporate governance on social responsibility disclosures in Indonesian companies. Variables of the characteristics and corporate governance used in this research include government ownership, board of directors size, independent directors, company size, company age, liquidity, leverage and type of industry towards corporate social responsibility disclosure.
The total sample which met the criteria consists of 443 companies that have been listed on the Indonesian Stock Exchange from the 2013-2017 period. Where is determined by purposive sampling method. The data used in this research are the annual reports and financial reports of all companies which are published through the IDX website. The data analysis method used is panel data regression. This research was processed using SPSS 25 and Eviews 10 programs.
The results of this research showed that the variable profitability, company size and company age have a positive significant effect on corporate social responsibility disclosure. While the independent director's variables have a negative significant effect on corporate social responsibility disclosure. Moreover, the research confirmed that other variables such as liquidity, board of directors size, leverage, government ownership, and type of industry were not found to have a significant effect.
Pengaruh Pengungkapan Tata Kelola Perusahaan terhadap Akurasi Harga Saham pada Perusahaan yang Terdaftar di Bursa Efek Indonesia Tahun 2013-2017
Authors: Harsono Budi , Saputra Edwin 
Published: February 2021

This study was conducted to analyze the effect of corporate governance disclosure to Share Price Accuracy. The variables of corporate governance disclosure in this study are divided into two namely Mandatory Corporate Governance Disclosure and Voluntary Corporate Governance Disclosure.
The data obtained in this research is secondary data. The Secondary data used are financial statement data and company annual report data. Secondary data can be downloaded from Indonesian stock exchanges official website via www.idx.co.id. The number of companies used as research samples are 393 companies. The study period began from 2013 to 2017. The data obtained were as many as 1965 data.
The conclusion of this study prove that both of the independent variables have a significant effect to Share Price Accuracy.Mandatory Corporate Governance Disclosure has a significant positive effect to the Share Price Accuracy partially.Voluntary Corporate Governance disclosure also has significant effect to the Share Price Accuracy partially.
Pengaruh Kualitas Audit dan Tata Kelola Perusahaan terhadap Manajemen Laba pada Perusahaan yang Terdaftar di Bursa Efek Indonesia
Authors: Tanujaya Kennardi , Verent Verent 
Published: February 2021

This study is aimed to analyze audit quality and corporate governance towards earning management. The independent variables used in this study are auditor size, specialist audit, tenure audit, ownership concentration, internal ownership, family ownership, institutional ownership, the board size, independent directors, and board activity. Meanwhile, leverage, company size, and operational cash flow are used as control variables in this study. Earning management is the dependent variable measured using discretionary accruals. This study has a sample of 360 companies listed on the Indonesia Stock Exchange within the 2014-2018 periods. Samples are analyzed using a purposive sampling method and there are 1,672 observational data examined in this study. Data are tested by applying the panel regression method.
The research concluded that independent variables which include specialist audits, ownership concentration, internal ownership, and institutional ownership do not significantly influence profit management. While results of the independent variables which include auditor size, audit tenure, family ownership, the board size, independent directors, and board activity are variables that have a significant positive relationship. Control variables that include leverage, company size, and operating cash flow have a significant effect on earning management that opposed the independent variable, which is significantly negative.
Perlindungan Hukum Terhadap Pencipta atau Pemegang Hak Cipta Lagu Dalam Pembayaran Royalti
Authors: Situmeang Ampuan , Kusmayanti Rita 
Published: February 2021

Intellectual property is the result of a work for an author that has exclusive rights that only exist and are attached to the owner or bearer of rights of a work. Other parties craving to use or use the copyright need to create or produce the work required in obtain the author's permission. The problems in this research were how is the legal protection for the creator or copyright holder of the song to the payment of royalties and how to complete the objection to approve the use of the song without paying royalties.
This research used normative research methods. Normative research is research on literature or document studies that support secondary research. Data collection from the results of the study was then analyzed by the author by qualitative-descriptive. Which is the type of research that aims to obtain about how the use of exclusive rights to economic rights that are still not properly implemented which requires an increase in the Author or the Copyright Holder.
Based on the research results and discussion, it can be concluded the use of exclusive rights to economic rights that are still not properly implemented which requires an increase in the Author or the Copyright Holder. The formation of LMKN is a form of protection given by the Government to the copyright of songs given also provides tariffs on royalties that must be agreed by the User. Dispute resolution can be done through litigation and non-litigation. Dispute resolution involving different countries can be done through the WIPO Arbitration and Meditation Center.
Korelasi Faktor Penyebab Tindak Kekerasan dalam Rumah Tangga Menggunakan Data Mining Algoritma A Priori
Authors: Buaton Relita , Maulita Yani , Kristiawan Andri 
Published: February 2021

Badan Keluarga Berencana dan Pemberdayaan Perempuan Kabupaten Langkat Sumatera Utara merupakan suatu instansi pemerintahan yang bertanggung jawab melayani masyarakat kabupaten Langkat dalam kasus kekerasan dalam rumah tangga(KDRT). Kekerasan dalam rumah tangga sudah termasuk masalah yang umum terjadi dalam kehidupan rumah tangga. Hal ini dikarenakan kurang harmonisnya hubungan dalam rumah tangga tersebut. Semakin banyaknya masyarakat yang melakukan tindakan kekerasan, maka perlu mencari solusi dan sebuah pengetahuan baru untuk mengatasi permasalahan ini dengan korelasi faktor penyebab tindak kekerasan dalam rumah tangga menggunakan algoritma a priori untuk menghasilkan kombinasi terdekat antar variabel. Teknik yang digunakan dalam aplikasi data mining ini adalah aturan asosiasi dengan algoritma a priori. Algoritma apriori ini melakukan proses iterasi untuk menghasilkan kombinasi item yang memiliki pola frekuensi tinggi, berdasarkan nilai ambang batas support dan confidence yang diberikan oleh user. Teknik ini menganalisis kombinasi faktor penyebab terjadinya tindak kekerasan dalam rumah tangga yang sering dialami korban berdasarkan pada data korban berjumlah 307 data kekerasan dalam rumah tangga. Melalui data tindak kekerasan dalam rumah tangga yang berjumlah 307 data, telah diperoleh hasil sebanyak 74 rule. Dan dari 74 rule yang terbentuk, telah ditemukannya rule terbaik dengan keterangan yaitu, seorang ibu rumah tangga cenderung mengalami jenis kekerasan berupa kekerasan fisik yang disebabkan oleh faktor ekonomi, support 20% dan confidence 76%.
Kata Kunci: Korelasi Faktor Penyebab Kekerasan Dalam Rumah Tangga, Algoritma A Priori.
Sistem Informasi Penjualan Pupuk Berbasis Web pada PT. Sri Aneka Karyatama
Authors: Asfinoza Asfinoza , Puspasari Shinta , Sunardi Hastha 
Published: February 2021

Sistem Informasi Penjualan adalah sistem yang digunakan untuk melakukan proses transaksi penjualan secara online di sistem ini pelanggan tidak perlu datang ke lokasi untuk membeli produk. Berdasarkan penelitian wrriter di PT. Sri Aneka Karyatama penelitian ini mengembangkan sistem informasi penjualan untuk PT. Sri Aneka Karyatama dimana beberapa masalah seperti jarak antara pelanggan dan perusahaan dalam proses pemesanan pupuk, kesalahan dalam mencatat pesanan, membutuhkan waktu sedikit lebih lama dalam membuat laporan, dan begitu banyak pesaing sehingga perusahaan ini membutuhkan media dan alat yang sangat besar. Tentang sebuah perusahaan dan produk di perusahaan ini, penulis menggunakan metodologi penelitian Iteratif metodologi ini disusun oleh 4 tahap, analisis pertama, desain kedua, pengkodean ketiga dan yang terakhir adalah sebuah ujian. Sistem ini dikembangkan dalam bahasa pemrograman PHP dan MySql sebagai sistem manajemen basis data, pada sistem ini terdapat data produk, data penjualan, data pengiriman, data produk sampingan, data pemasok dan laporan penjualan, sehingga dengan adanya Sistem Informasi Pembuatan Pupuk Penjualan ini, dapat membantu mempermudah proses transaksi pupuk pupuk, dan sebagai media promosi.
Kata Kunci: Sistem, Informasi, Penjualan, Pupuk, Web, PHP, MySql.
Implementasi Mail Server Berbasis Squirrelmail Dengan Exchange Server Menggunakan Teknologi Virtualisasi di SMK Negeri 1 Pendalian IV Koto
Authors: Basorudin Basorudin 
Published: February 2021

Teknologi virtualisasi server merupakan penggunaan bersama satu mesin fisikal oleh beberapa sistem operasi server. Perancangan dan implementasi mail server ini dibangun dengan menggunakan Debian.5 sebagai base operating system server. Perancangan dan implementasi mail server ini dibangun dengan menggunakan dns server, web server dan mail server/squirrelmail, di konfigurasi menggunakan bantuan aplikasi virtualbox sebagai server. DNS (Domain Name System) adalah sebuah sistem yang menyimpan informasi tentang nama host maupun nama domain dalam bentuk basis data tersebar (distributed database) di dalam jaringan komputer, misalkan Internet. Aplikasi yang digunakan untuk menangani penghantaran pesan mail adalah mail server. Mail server ini senantiasa menerima pesan dari e-mail client yang digunakan user, atau mungkin dari server e-mail lainnya. Web mail berfungsi untuk mengirim dan melihat pesan email melalui web browser. Konfigurasi squirrelmail dilakukan dengan menjalankan skrip conf.pl : $/var/www/wemail/config/ conf.pl. Layanan Exchange Server antara lain : Directory Service, Simple Mail Transfer Protocol (SMTP), Post Office Protocol ( POP3 ), IMAP (Internet Message Access Protocol), Complementary Services, System Attendant. Untuk Proses Pengiriman Mail Server dapat dilihat pada nomor 5.2.
Kata Kunci: Squirrelmail, Exchange Server, DNS Server, Web Server, Mail Server.
Penerapan Algoritma Greedy Dalam Pencarian Jalur Terpendek Pada Instansi-Instasi Penting Di Kota Argamakmur Kabupaten Bengkulu Utara
Authors: Darnita Yulia , Toyib Rozali 
Published: February 2021

Pencarian instansi – instansi penting di kota argamakmur merupakan hal yang penting dilakukan oleh orang – orang dari luar daerah dalam melakukan perpindahan baik nonpermanen (sementara) atau permanen (menetap) di sebuah wilayah , dengan demikian bahwa faktor kesulitan dalam mengakses jarak serta waktu salah satu hal yang perlu di pertimbangkan agar mendapatkan informasi dimana letak posisi instansi – instansi yang tepat dan akurat. Pada saat pencarian, Algoritma Greedy bekerja dengan mencari titik bobot yang terkecil dengan menghitung rute yang dilewati dan Algoritma Greedy melakukan perhitungan bobot tergantung dari bobot tahapan yang telah dilewati dan bobot pada tahap itu sendiri. Berdasarkan hasil pengujian sistem yang dibuat : Pemda waktu tempuh 10 menit jalur terpendek gunung alam, Capil waktu tempuh 10 menit jalur terpendek karang suci, Porles waktu tempuh 8 menit jalur terpendek bundaran, Pemadam Kebakaran waktu tempuh 10 menit jalur terpendek alun – alun, PLN waktu tempuh 10 menit jalur terpendek alun – alun, Rumah Sakit Umum Daerah (RSUD) waktu tempuh 6 menit jalur terpendek Rama Agung, Adapun jalur terpendek bisa saja jarak tempuhnya lebih lama di karena keramaian dan kepadatan kependuduk untuk menjalankan sistem ini di butuhkan jaringan internet yang memadai.
Kata Kunci: Pencarian Jalur Terdekat , Instansi , Jarak, Algoritma Greedy.