bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mania and hypomania associated with COVID-19: a series of 15 cases seen by the consultation-liaison psychiatry service in Qatar
Authors: Iqbal Yousaf , Alabdulla Majid , Latoo Javed , Kumar Rajeev , Albrahim Sultan , Wadoo Ovais , M Haddad Peter 
Published: November 2021

Background: A range of neuropsychiatric diagnoses have been reported in association with coronavirus disease 2019 (COVID-19). However, only sporadic cases of mania or hypomania have been reported in patients with COVID-19. This study aimed to report clinical characteristics of 15 consecutive cases of COVID-19-associated mania or hypomania seen in three general hospitals in Qatar in the early months of the pandemic in 2020.
Methods: This study is a retrospective case-note review of 15 cases of COVID-19-associated mania or hypomania (confirmed by polymerase chain reaction test), seen as inpatient consultations out of the first 100 consecutive patients managed by consultation-liaison psychiatric teams in Qatar between 2 March 2020 and 7 July 2020.
Results: The mean age of the 15 patients was 40 years. Twelve patients had mania, and three had hypomania. Regarding the physical severity of COVID-19, 10 patients were asymptomatic, two had upper respiratory tract symptoms alone and three had pneumonia. None of the patients were intubated. Potential risk factors for mania/hypomania included pandemic-related psychosocial stress before admission (n = 9), past history of mania/bipolar disorder (n = 6) or psychosis (n = 2), raised inflammatory markers (n = 7) and steroid use (n = 3). None had a history of recent substance misuse. Other than one patient with advanced cancer, none had comorbidity regarded as likely to have caused mania or hypomania. Three patients had mild white matter ischaemic changes on brain imaging. Standard pharmacological treatment for mania (i.e. antipsychotic medication supplemented by prn benzodiazepines) was effective. Ten patients were discharged home from the COVID-19 facility where they presented, but five required transfer to Qatar's psychiatric hospital for further treatment of mania.
Conclusion: The association of mania or hypomania with COVID-19 may be spurious (e.g. representing an initial presentation of bipolar disorder) or causal. The reported cases illustrate a range of potential aetiological mechanisms by which COVID-19 could cause mania or hypomania. Cohort studies are necessary to determine the incidence, aetiology and prognosis of COVID-19-associated mania/hypomania.
Amenities como Estratégia De Marca e Encantamento de Clientes
Authors: Rayane Silva Míriam , Cavalcante Dias Maria Carolina , Fernandes Ferreira Lissa Valéria 
Published: November 2021

Os amenities, produtos de higiene pessoal disponibilizados aos hóspedes pelos estabelecimentos de hospedagens, se apresentam como elementos potenciais para gerar valor agregado, cativar, encantar e fidelizar os hóspedes e para dar maior visibilidade para as marcas dos meios de hospedagem. Neste contexto, o presente trabalho analisa, em duas etapas, os produtos de higiene pessoal ofertados pelos hotéis localizados na Via Costeira na cidade Natal, Rio Grande do Norte, Brasil. Foram identificados quais produtos são oferecidos e seus os atributos diferenciadores e, em seguida, a avaliação de qualidade a partir da percepção de especialistas e um comparativo entre os produtos utilizados pelos hotéis pesquisados, a fim de discutir as possíveis contribuições que estes produtos fornecem às respectivas marcas hoteleiras. O estudo adotou abordagem metodológica qualitativa, descritivo-exploratória, e utilizou a técnica “teste cego” para a coleta, e a análise de conteúdo para tratamento dos dados. Diante dos resultados obtidos, conclui-se que os amenities oferecidos pela maioria dos hotéis da Via Costeira não apresentam diferenciais significativos, revelando a necessidade da melhoria da sua qualidade e do seu uso como estratégia de marca e encantamento de clientes pelos hotéis pesquisados.
Profil Peredaran Obat Disfungsi Ereksi Ilegal
Authors: Elfarabi Fauqi , Handayani Fuji , Arrahman Yovia Rizki , Santoso Ari Andriano 
Published: November 2021

Tren temuan obat ilegal yang beredar di Indonesia terus mengalami peningkatan dari tahun 2008 – 2018. Pada periode tersebut, obat golongan kelas terapi disfungsi ereksi menjadi data yang mendominasi dengan frekuensi temuan paling banyak. Hal ini juga diperkuat oleh data Public Warning BPOM dan laporan Post Market Alert System tahun 2015 – 2017 dimana pada periode tersebut obat tradisional mengandung bahan kimia obat golongan disfungsi ereksi marak ditemukan. Penyusunan penelitian ini dilakukan dengan metode kualitatif dan kuantitatif dengan tujuan untuk mengidentifikasi situasi peredaran (termasuk pengguna), menggambarkan potensi nilai peredaran obat disfungsi ereksi ilegal di Indonesia, dan potensi penyimpangan distribusi bahan baku obat disfungsi ereksi. Penelitian dilakukan pada 8 (delapan) kota di Indonesia, yaitu Jabodetabek, Serang, Padang, Bandung, Semarang, Surabaya, Bali, dan Samarinda. Hasil penelitian menunjukkan bahwa peredaran obat disfungsi ereksi secara luring melalui kios permanen/lapak/gerobak di Indonesia masih banyak ditemukan dan peredaran obat disfungsi ereksi secara daring juga mengalami peningkatan dengan adanya perluasan pasar melalui website, media sosial, dan e-commerce. Profil pengguna obat golongan disfungsi ereksi berada pada kelompok usia produktif (30 – 45 tahun) dengan tingkat penghasilan antara Rp 2.000.000,- hingga Rp 4.000.000,- serta merk yang paling banyak dikonsumsi adalah Viagra. Potensi diversi peredaran bahan baku obat disfungsi ereksi terjadi pada proses importasi bahan baku dan penyaluran dari masing – masing PBF/importir kepada industri farmasi.
PERENCANAAN GARDU DISTRIBUSI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS TADULAKO
Authors: Arifudin Arifudin , Tribianto Tribianto , Sarjan Muhammad , Mukhlis Baso 
Published: November 2021

The Faculty of Teacher Training and Education is one of the Faculties that has the most buildings in Tadulako University, which of course requires large capacity electrical equipment facilities and also requires large electric power as well. To provide optimal services so that lecture, practicum and other activities are not disrupted due to electrical problems.
Electricity problems at the Faculty of Teacher Training and Education are currently caused by excessive loading that is not adjusted to the transformer capacity at the Economic Substation, The distance that is served by the Economic Substation is approximately 950 meters so that it causes losses on the network.
Based on the calculation of the total load obtained for lighting, room conditioning and auxiliary contact boxes of 167,402 kVA and considering the addition of Loads and Buildings within the Faculty of Teacher Training and Education, the transformer capacity used is 200 kVA and according to SPLN Transformers with capacities below 200 kVA must use Portal substation construction.
PERANCANGAN ZETA CONVERTER PADA PELACAKAN TITIK DAYA MAKSIMUM PHOTOVOLTAIC MENGGUNAKAN ALGORITMA MODIFIKASI HILL CLIMBING
Authors: Mahmudi Irwan , Jumiyatun Jumiyatun , Mukhlis Baso , Lukman Lukman 
Published: November 2021

Electrical energy is a primary need at this time, which almost all human activities require electricity. The electrical energy we use today is a conversion from other energy, partly derived from fossil energy, which is energy that cannot be renewed and will run out if it is continuously explored and exploited. Solar energy is a renewable energy source that has the potential to be converted to electrical energy using solar panels or so-called photovoltaics.
Photovoltaic has a drawback in its use, namely the output value is very dependent on environmental conditions. To maximize the power efficiency between the photovoltaic output and the power to be used by the load, a method is needed, namely Maximum Power Point Tracking (MPPT). In the application of this MPPT DC-DC Zeta converter is used with a hill climbing algorithm to achieve the value of the output voltage and current at maximum power. With this method, it is expected that MPPT control is reliable and easy to apply.
In this study, the type of photovoltaic module used is the 60 Wp monocrystalline type with sampling data once an hour from 09.00 - 17.00 WITA, the tracking speed data obtained by the modified hill climbing algorithm is 0.142 seconds on average with an average efficiency of 99.969 %.
Disability and Difference on the New Zealand Frontier
Authors: Snoddy Anne Marie , King Charlotte , Petchey Peter , Miszkiewicz Justyna , Kinaston Rebecca , Buckley Hallie 
Published: November 2021

The mid-nineteenth century saw extensive diaspora from Europe to the antipodes. New Zealand in particular was marketed to the poor and middle classes of the United Kingdom (UK) as a “Better Britain”; a pastoral utopia of abundant resources and easy living. These campaigns actively targeted young, able-bodied persons with the aim of creating a thriving and productive colony. The rural community of Milton, Otago, in the South Island, was a farming settlement established predominantly by immigrants from the UK. The University of Otago undertook an excavation at St. John’s Anglican burial ground (SJM) in 2016 with the aim of reconstructing some aspects of the lives of these nineteenth-century European (Pākehā) settlers. One of the 27 individuals recovered, burial 29, was an adult female with a striking thoracic deformity and several other features suggestive of a skeletal growth disorder. Here, we combine multiple lines of bioarchaeological evidence to create an osteobiographyof this individual and discuss the implications of our findings for conceptions of disability, status, personhood, and social value in Victorian frontier society.

Tuhinga whakarāpopoto: Ko te puku o ngā tau o te rau tau 1800 te wā i matua heke ai ngā tāngata nō Ūropi ki te tuakoi tonga o te ao. Ko Niu Tīreni tonu i whakatairangahia ki te tūtūā o Peretānia hei Piritana hōu, he “Piritana Pai Ake ”; he whenua haumako, he huhua rauemi, he oranga ngāwari. Ko ēnei whakatairanga hei whaka- poapoa i te hunga rangatahi, i te hunga kua pakari tonu te tīnana hei tuarā hāpai i te koroni hōu, i te koroni tōnui i pīrangitia. Ko te taiwhenua o Milton i Ōtākou, i Te Waipounamu, tētehi hapori pāmu i whakatūria e ngā manene, ko te nuinga nō Peretānia. Nā Te Whare Wānanga o Ōtākou ngā rua kōiwi i te urupā Mihinare o Hato Hone (SJM) i keri ake i te tau 2016, ko te whainga matua ko te kimi kōrero mō ngā rā o ngā ao o ēnei tāngata whai nō Ūropi (Pākehā) i te rau tau 1800. Ko tētehi o te 27 tāngata i hahua, arā ko “nehunga 29”, he wahine pa- keke kua hauā rawa ōna kōiwi o te haurua o te tinana ō runga i tōna pito, ā, he tohu anō i kitea e hanga rite ana ki tētehi mate whakahauā kōiwi. I konei whakatōpūhia ai ngā taunakitanga maha kua puta i ngā whakamātautau kōiwi tangata hei waihanga anō i ngā rā o te ao o te wahine nei, ā, ka matapakina ā mātou whakapae mō ngā whakaaro o ngāi koroni wikitōria mō te hauā; mō tōna tūnga, mō tōna mana me tōna noho hei tangata i aua wā.
Internet risky behaviours among youth with visual impairment
Authors: Agnieszka Wrzesińska Magdalena , Knol-Michałowska Kamila , Stecz Patryk , Kopytowska Monika , Binder-Olibrowska Katarzyna 
Published: November 2021

Background
Young individuals with visual impairment (VI), exposed to higher risky of social exclusion, might be more prone to Internet risky behaviours including electronic aggression.

Objective
Different types of Internet risky behaviours and the average time spent online were investigated among students with VI. These behaviours were analyzed for the relationship with witnessing, perpetrating and becoming a victim of electronic aggression.

Methods
A total of 490 special needs school students with VI answered a self-administered questionnaire. The average time spent online, different types of risky Internet activities and electronic aggression were recorded, as well as sociodemographic characteristics.

Results
Male students downloaded software illegally, hacked, published and viewed sites with sexual content, and gambled online statistically more often than female counterparts. Concerning electronic aggression, more than half of participants were engaged as witnesses, every fifth student as a victim and 11.6% as perpetrators. Two sets of ordinal logistic regression analyses have shown that communication with a person promoting violence and an excessive amount of time spent online during weekends predicted significantly the risk of witnessing and being a victim of electronic aggression. Additionally, communicating with a person promoting violence and an excessive amount of time spent online during schooldays were associated with increased odds for engagement in electronic aggression as a perpetrator.

Conclusions
Population with VI is prone to risky Internet use and likely to be engaged in electronic aggression. New instruments and preventive strategies need to be developed, as well as diagnostic tools tailored specifically to the needs of young people with VI.
Staphylococcal Epidermolysis: A Case Report
Authors: Mebrouk Nadia , Berrada Hamza , Kriouile Yamna , Alaoui Asmaa Mdaghri 
Published: November 2021

Acute staphylococcal epidermolysis, also known as staphylococcal scalded skin syndrome (SSSS), in young children is caused by the release of exfoliative toxins A and B (ETA and/or ETB) from an initial outbreak which can be ear-nose-throat, conjunctival or cutaneous.
Staphylococcal scalded skin syndrome is characterized by painful erythroderma, quickly followed by generalized detachment with respect to mucous surfaces, regressing in 2 to 4 days on antibiotics. The positive diagnosis is mainly based on clinical examination and sometimes on skin biopsy.
The course of the disease is benign, favored by anti-staphylococcal treatment combined with local care. However, the risk of fatal course is estimated at around 4% in the event of delay in antibiotic treatment. We report the case of an infant with SSSS, diagnosed and treated early with good evolution.
In-vivo Antiplasmodial Effect of Dihydroartemisinin-Piperaquine-Nitrofurantoin on Plasmodium berghei- Infected Mice
Authors: Georgewill Udeme O. , Joseph Festus Azibanigha , Adikwu Elias 
Published: November 2021

Nitrofurantoin (NT) used for the treatment of urinary tract infections may have antiplasmodial activity. Dihydroartemisinin-piperaquine (DP) is an artemisinin based combination therapy used for the treatment of malaria. This study evaluated the antiplasmodial effect of dihydroartemisinin-piperaquine-nitrofurantoin (DP-NT) on mice infected with Plasmodium berghei. Adult Swiss albino mice (30-35 g) of both sexes were used. The mice were randomly grouped, inoculated with Plasmodium berghei, and treated orally with DP (1.7/13.7 mg/kg), NT (57.1 mg/kg) and DP-NT (1.71/13.7/ 57.1 mg/kg), respectively using curative, prophylactic and suppressive tests. The negative control was orally treated with normal saline (0.3 mL), while the positive control was orally treated with chloroquine CQ (10mg/kg). After treatment, blood samples were collected and evaluated for percentage parasitemia, inhibitions and hematological parameters. Liver samples were evaluated for histological changes. The mice were observed for mean survival time (MST). Treatment with DP-NT decreased parasitemia levels when compared to individual doses of DP and NT with significant difference observed at p<0.05. DP-NT prolonged MST when compared to individual doses of DP and NT with significant difference observed at p<0.05. The decrease in packed cell volume, red blood cells, hemoglobin and increase in white blood cells in parasitized mice were significantly restored by DP-NT when compared to individual doses of DP and NT with difference observed at p<0.05. DP-NT eradicated liver Plasmodium parasite. NT remarkably increased the antiplasmodial activity of DP. DP-NT may be used for the treatment of malaria.
New Possibilities of Refractive Modeling of the Cornea by the Radiation of an Argon-fluorine Excimer Laser
Authors: Kornilovskiy I. M. 
Published: November 2021

Purpose: To consider new possibilities of refractive modeling of the cornea by the radiation of an argon-fluorine excimer laser in ablative and subablative modes after saturation of the stroma with riboflavin.
Materials and Methods: Experimental (20 pork, 90 rabbit eyes) and clinical studies on photorefractive and phototherapeutic operations with saturation of the corneal stroma with riboflavin (610 operations) were analyzed. To activate riboflavin, secondary radiation induced by exposure to ablative and subablative energy densities was used. A quick transition to energy densities below the ablation threshold without additional calibrations was carried out using a “Microscan Visum-500” excimer laser (Optosystems, Russia). An objective assessment of the refractive keratomodelling effect and visual results was carried out according to the data of complex optometric studies.
Results: Experimental and clinical studies have shown the advantages of refractive keratomodeling by theradiation of an argon-fluorine excimer laser in ablative and subablative modes after saturation of the stroma with riboflavin. Isotonic 0.25% riboflavin solution did not affect the accuracy of refractive ablation and blocked the negative effect of induced secondary radiation on keratocytes and corneal nerves. This reduced the aseptic inflammatory response and the risk of developing an irreversible form of fibroplasia. Ablation with riboflavin initiated a damped crosslinking effect, which increased the photoprotective and strength properties of the thinned cornea. A refractive keratomodelling effect was found when energy densities were applied below the stromal ablation threshold. The magnitude of this refractive effect depended on the total radiation dose and the topography of the affected area. This approach made it possible to implement laser-induced refractive keratomodeling without ablation of the corneal stroma.
Conclusion: Refractive modeling of the cornea by the radiation of an argon-fluorine excimer laser in ablative and subablative modes after saturation of the stroma with riboflavin opens up new possibilities in laser correction of ametropia.
Antimicrobial Polypeptides Capable of Membrane Translocation for Treatment of MRSA Wound Infection In Vivo
Authors: Yang Shengcai , Wang Yanming , Tan Jason , Teo Jye Yng , Tan Ko Hui , Yang Yi Yan 
Published: November 2021

AbstractMultidrug resistant infections are plaguing the healthcare sector over the past few decades with limited treatment options. To overcome this problem, the authors synthesize a series of novel guanidinium‐functionalized polypeptides. Specifically, poly(l‐lysine) (PLL) with different lengths is first synthesized by ring‐opening polymerization of Nε‐benzyloxycarbonyl‐l‐lysine‐N‐carboxyanhydride (Lys(Z)‐NCA) followed by functionalization with a guanidinium‐functional group to obtain guanidinium‐functionalized PLL (PLL‐Gua). To study the effect of hydrophobicity on antimicrobial activity, relatively more hydrophobic leucine‐NCA monomer or hydrophobic vitamin E moiety is introduced to PLL‐Gua. These polypeptides are characterized for antimicrobial activity against a panel of microbes including multidrug‐resistant bacteria, and hemolytic activity. Among all the polypeptides, PLL22‐Gua is most effective against bacteria and yeast. Particularly, excellent bactericidal activity is observed against Staphylococcus aureus and MRSA. PLL22‐Gua kills bacteria mainly by membrane translocation. In addition, PLL22‐Gua kills MRSA with low resistance frequency (<3.3 × 10−8). In an MRSA‐caused wound infection mouse model, two‐day treatment (twice daily) with 10, 20, or 40 mg per kg of PLL22‐Gua shows up to 99.5% bacterial removal. Moreover, no acute dermal toxicity is observed even at a dose of 200 mg per kg. These promising results show the excellent potential of PLL22‐Gua as an antimicrobial agent against multidrug‐resistant infection in vivo.
22q11.2 duplications: Expanding the clinical presentation
Authors: Bartik Lauren E. , Hughes Susan S. , Tracy Meghan , Feldt M. Max , Zhang Lei , Arganbright Jill , Kaye Alison 
Published: November 2021

Abstract22q11.2 duplication syndrome has a frequency of ~1/700 in the intellectual disability population. Despite this frequency, there is limited information on the variable clinical presentation. Although the phenotype and incidence of congenital anomalies are well described for 22q11.2 deletion syndrome, they are not as well understood for individuals with 22q11.2 duplication syndrome. This study is a single‐center, retrospective review of patients diagnosed with 22q11.2 duplication syndrome designed to categorize the variable phenotype seen in these individuals. The data suggest that the incidence of congenital anomalies may be higher than previously reported for this syndrome. Affected individuals are at increased risk for a variety of problems including gastrointestinal complications, endocrine dysfunction, ophthalmologic abnormalities, palatal anomalies, congenital heart disease, musculoskeletal differences, and neurologic abnormalities. Individuals with 22q11.2 duplication syndrome would benefit from care coordinated by a multidisciplinary team and managed according to the 22q11.2 deletion syndrome guidelines.
Adaptation of mammals to hypoxia
Authors: Li Fang , Qiao Zhenglei , Duan Qijiao , Nevo Eviatar 
Published: November 2021

AbstractOxygen plays a pivotal role in the metabolism and activities of mammals. However, oxygen is restricted in some environments—subterranean burrow systems or habitats at high altitude or deep in the ocean—and this could exert hypoxic stresses such as oxidative damage on organisms living in these environments. In order to cope with these stresses, organisms have evolved specific strategies to adapt to hypoxia, including changes in physiology, gene expression regulation, and genetic mutations. Here, we review how mammals have adapted to the three high‐altitude plateaus of the world, the limited oxygen dissolved in deep water habitats, and underground tunnels, with the aim of better understanding the adaptation of mammals to hypoxia.
Fluorescent hydrogel of chitosan and gelatin cross‐linked with maleic acid for optical detection of heavy metals
Authors: Sethi Sapna , Medha  , Singh Gurkarandeep , Sharma Rashmi , Kaith Balbir Singh , Sharma Neeraj , Khullar Sadhika 
Published: November 2021

AbstractA multi‐component, fluorescent hydrogel of chitosan and gelatin using maleic acid as a cross‐linking agent was fabricated with improved mechanical and thermal properties. The FTIR spectroscopy and SEM studies confirmed the formation of a cross‐linked and porous hydrogel. The XPS studies confirmed the presence of rich functionalities over the surface of hydrogel. The hybrid hydrogel possessed strong blue emission band centered at 438 nm when excited with an absorption band centered at 384 nm. The fluorescent hydrogel was tested for selective detection of different heavy metal ions including Cr (VI) in the aqueous solution. The strong complexation among the functional groups of hydrogel and metal ions led to the quenching of hydrogel's fluorescence. The fluorescence of hydrogel was quenched significantly in the presence of Cr (VI) ions in comparison to the other heavy metal ions. The fluorescence‐quenching efficiency displayed a linear response to the Cr (VI) concentration in the range of 1–14 nM with a lower detection limit of 0.12 nM. Embraced with good sensitivity and selectivity for Cr (VI) ions, the solid hydrogel with stable fluorescent properties holds a great potential in chemical sensing applications.