bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-situ remediation of nitrogen and phosphorus of beverage industry by potential strains Bacillus sp. (BK1) and Aspergillus sp. (BK2)
Authors: Bhambri Anne , Karn Santosh Kumar , Singh R. K. 
Published: June 2021

AbstractThe bioremediation of beverage (treated and untreated) effluent was investigated in the current study by using the potential strains of Bacillus sp. (BK1) and Aspergillus sp. (BK2). Effluent was collected from the beverage industry (initial concentration of nitrogen were 3200 ± 0.5 mg/L and 4400 ± 0.6 mg/L whereas phosphorus were 4400 ± 2 mg/L and 2600 ± 1 mg/L in treated and untreated effluent correspondingly). Further, the BK1 and BK2 exhibited high removal competence after 1 week of incubation; BK1 removed phosphorus 99.95 ± 0.7% and BK2 95.69 ± 1% in treated effluent while nitrogen removed about 99.90 ± 0.4% by BK1 and 81.25 ± 0.8% by BK2 (initial concentration of phosphorus 4400 ± 2 mg/L and nitrogen 3200 ± 0.5 mg/L). Next, in the untreated effluent BK1 removed 99.81 ± 1% and BK2 99.85 ± 0.8% of phosphorus while removed nitrogen 99.93 ± 0.5% by BK1 and 99.95 ± 1.2% by BK2 correspondingly, (initial concentration of phosphorus 2600 ± 1 mg/L and nitrogen 4400 ± 0.6 mg/L). The physiochemical composition of sample such as pH, total carbohydrates, total proteins, total solids of treated and untreated effluent were also analysed before and after treatment of both the samples. BK1 and BK2 increased the pH by 8.94 ± 0.3 and 9.5 ± 0.4 correspondingly in treated effluent whereas 6.34 ± 0.5 and 7.5 ± 0.2 correspondingly in untreated effluent (initial pH of treated and untreated effluent 7.07 ± 0.8 and 4.85 ± 0.3 correspondingly). Total Carbohydrates removed about 17,440 ± 4.6 mg/L and 10,680 ± 3.2 mg/L by BK1 and BK2 correspondingly in treated effluent whereas 18,050 ± 3.5 mg/L and 18,340 ± 2.3 mg/L correspondingly in untreated effluent (initial concentration of treated and untreated effluent 25,780 ± 1.6 mg/L and 35,000 ± 1.5 mg/L correspondingly) while BK1 and BK2 removed total proteins by 30.336 ± 4.6 mg/L and 40.417 ± 2.3 mg/L correspondingly in treated effluent whereas 18.929 ± 1.2 mg/L and 17.526 ± 0.8 mg/L correspondingly in untreated effluent (initial concentration of treated and untreated effluent 49.225 ± 1.5 mg/L and 20.565 ± 1 mg/L correspondingly). Next, total solids removed by BK1 and BK2 2.5 ± 0.3 mg/L and 1.6 ± 0.6 mg/L correspondingly in treated effluent whereas 5.5 ± 0.8 mg/L and 4.6 ± 0.6 mg/L in untreated effluent (initial concentration of treated and untreated effluent 5.6 ± 1.5 mg/L and 9.48 ± 1.2 mg/L correspondingly). Both the strains BK1 and BK2 are highly efficient in the nitrogen and phosphorus removal therefore this strain may be applied for the potential remediation.
Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients
Authors: Li Zheng , Wu Qiuji , Meng Xiangyu , Yu Haijun , Jiang Dazhen , Chen Gaili , Hu Xiaoyan , Hua Xinying , Wang Xiaoyong , Wang Dajiang , Zhao Hongli , Zhong Yahua 
Published: June 2021

AbstractRadiotherapy-related caries is a complication of radiotherapy for nasopharyngeal carcinoma; however, factors influencing the occurrence, accurate prediction of onset, and protective factors of radiotherapy-related caries remain unclear. This study analyzed risk factors, disease predictors, and protective factors for radiotherapy-related caries in nasopharyngeal carcinoma. This prospective study included 138 nasopharyngeal carcinoma patients receiving radical radiotherapy at our hospital during June 2012–December 2016 and were followed up for dental caries. Patients’ clinical data on radiotherapy were collected, dynamic monitoring was performed to assess changes in oral pH values, and a questionnaire survey was administered to collect patients’ lifestyle habits. Time-dependent cox regression trees, event-free Kaplan–Meier curve, Mann–Whitely U test were used to analysis the results. The median follow-up time was 30 (12–60) months. Radiotherapy-related caries occurred in 28 cases (20.3%). Univariate analyses showed that radiotherapy-related caries was associated with patient’s age, oral saliva pH value, green tea consumption, and radiation dose to sublingual glands, but not with the radiation dose to the parotid and submandibular glands. Multivariate analysis showed that oral saliva pH value [hazard ratio (HR) = 0.390, 95% confidence interval = 0.204–0.746] was an independent prognostic factor for radiotherapy-related caries. Patients with oral saliva pH values ≤ 5.3 in the 9th month after radiotherapy represented a significantly higher risks for radiotherapy-related caries (p < 0.001). Green tea consumption was associated with the occurrence of radiotherapy-related caries, and oral saliva pH values could predict the occurrence of radiotherapy-related caries. Limiting radiation doses to sublingual glands can reduce the occurrence of radiotherapy-related caries.
Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19
Authors: Le Brian L. , Andreoletti Gaia , Oskotsky Tomiko , Vallejo-Gracia Albert , Rosales Romel , Yu Katharine , Kosti Idit , Leon Kristoffer E. , Bunis Daniel G. , Li Christine , Kumar G. Renuka , White Kris M. , García-Sastre Adolfo , Ott Melanie , Sirota Marina 
Published: June 2021

AbstractThe novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected samples. Using a rank-based pattern matching strategy based on the Kolmogorov–Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated 16 of our top predicted hits in live SARS-CoV-2 antiviral assays in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19.
The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
Authors: Yoshida Yuta , Kawabata Fuminori , Nishimura Shotaro , Tabata Shoji 
Published: June 2021

AbstractThe characterization of molecular mechanisms underlying the taste-sensing system of chickens will add to our understanding of their feeding behaviors in poultry farming. In the mammalian taste system, the heterodimer of taste receptor type 1 members 1/3 (T1R1/T1R3) functions as an umami (amino acid) taste receptor. Here, we analyzed the expression patterns of T1R1 and T1R3 in the taste cells of chickens, labeled by the molecular markers for chicken taste buds (vimentin and α-gustducin). We observed that α-gustducin was expressed in some of the chicken T1R3-positive taste bud cells but rarely expressed in the T1R1-positive and T2R7-positive taste bud cells. These results raise the possibility that there is another second messenger signaling system in chicken taste sensory cells. We also observed that T1R3 and α-gustducin were expressed mostly in the vimentin-positive taste bud cells, whereas T1R1 and bitter taste receptor (i.e., taste receptor type 2 member 7, T2R7) were expressed largely in the vimentin-negative taste bud cells in chickens. In addition, we observed that T1R1 and T1R3 were co-expressed in about 5% of chickens' taste bud cells, which express T1R1 or T1R3. These results suggest that the heterodimer of T1R1 and T1R3 is rarely formed in chickens’ taste bud cells, and they provide comparative insights into the expressional regulation of taste receptors in the taste bud cells of vertebrates.
Prediction of functional properties of nano $$\hbox {TiO}_2$$ coated cotton composites by artificial neural network
Authors: Amor Nesrine , Noman Muhammad Tayyab , Petru Michal 
Published: June 2021

AbstractThis paper represents the efficiency of machine learning tool, i.e., artificial neural network (ANN), for the prediction of functional properties of nano titanium dioxide coated cotton composites. A comparative analysis was performed between the predicted results of ANN, multiple linear regression (MLR) and experimental results. ANN was applied to map out the complex input-output conditions to predict the optimal results. A backpropagation ANN model called a multilayer perceptron (MLP), trained with Bayesian regularization were used in this study. The amount of chemicals and reaction time were selected as input variables and the amount of titanium dioxide coated on cotton, self-cleaning efficiency, antimicrobial efficiency and ultraviolet protection factor were analysed as output results. The accuracy of the proposed algorithm was evaluated and compared with MLR results. The obtained results reveal that MLP provides efficient results that are statistically significant in the prediction of functional properties ($$p<0.1 e^{-10} $$

p
<
0.1

e

-
10

) compared to MLR. The correlation coefficient of MLP model ($$>95\%$$

>
95
%

) indicates that there is a strong correlation between the measured and predicted functional properties with a trivial mean absolute error and root mean square errors values. MLP model is suitable for the functional properties and can be used for the investigation of other properties of nano coated fabrics.
Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
Authors: Calandria Jorgelina M. , Bhattacharjee Surjyadipta , Maness Nicholas J. , Kautzmann Marie-Audrey I. , Asatryan Aram , Gordon William C. , Do Khanh V. , Jun Bokkyoo , Mukherjee Pranab K. , Petasis Nicos A. , Bazan Nicolas G. 
Published: June 2021

AbstractThe pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA, n-3) activate ELV biosynthesis in lung cells. Both ELVs and their precursors reduce the binding to RBD. ELVs downregulate angiotensin-converting enzyme 2 (ACE2) and enhance the expression of a set of protective proteins hindering cell surface virus binding and upregulating defensive proteins against lung damage. In addition, ELVs and their precursors decreased the signal of spike (S) protein found in SARS-CoV-2 infected cells, suggesting that the lipids curb viral infection. These findings open avenues for potential preventive and disease-modifiable therapeutic approaches for COVID-19.
Strong bases behave as weak bases in nanoscale chemical environments: implication in humidity-swing CO2air capture
Authors: Han Yingying , Zhu Liangliang , Yao Yutong , Shi Xiaoyang , Zhang Yayun , Xiao Hang , Chen Xi 
Published: June 2021

The reaction of guanidine–H2O and guanidine–CO2 in nanoscale chemical environments was studied using ab initio calculations, which can provide valuable theoretical guidance for the design of CO2 air capture sorbents using guanidine-based materials.
Visible-light driven redox system of water-soluble zinc porphyrin and platinum nanoparticles for selective reduction of pyruvate to lactate
Authors: Kita Yu , Amao Yutaka 
Published: June 2021

A selective pyruvate reduction to lactate using a visible light-driven redox system consisting of water-soluble zinc porphyrin as a photosensitizer, methylviologen as an electron mediator and platinum nanoparticles dispersed on poly(vinylpyrrolidone) as a catalyst, is developed as a new lactate production method without toxic substances.
Differential expression of miRNAs as biomarkers for predicting the outcomes of diffuse large B-cell lymphoma patients
Authors: Hu Maogui , Wang Xinchen , Liu Ning , Ding Kaiyang , Zhang Guihong , Liu Xiaosi 
Published: June 2021

Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) used to be defined as germinal center B-like and non-germinal center B-like subtypes, associated with different prognoses, but the conventional classification does not meet the needs of clinical practice because of DLBCL heterogeneity, a problem that might be improved by selection of miRNAs as biomarkers.
Methods: Twelve patients with DLBCLs were used to screen out the aberrant miRNA profile using miRNA microarray technology in two patient subtypes (six germinal center B-like and six non-germinal center B-like patients). The potential biomarkers were further analyzed using the quantitative reverse transcription-polymerase chain reaction method in 95 DLBCL patients to investigate relationships among expression levels of potent miRNA, clinicopathological features and survival rates of patients.
Results: miR-208a-5p, miR-296-5p and miR-1304-5p were screened as potential biomarkers. miR-208a-5p and miR-296-5p were shown to be associated with better survival of patients after Kaplan–Meier analysis, whereas miR-1304-5p overexpression indicated a poor survival prognosis independent of the DLBCL subtype. In addition, changes of miR-296-5p and miR-1304-5p expression, the International Prognostic Index (IPI) status and the age of patients were all independent indicators for DLBCL prognosis. We also found that high miR-208a-5p expression led to better outcomes in DLBCL patients with similar IPI scores; however high miR-1304-5p expression tended to indicate the opposite.
Conclusions: MiR-208a-5p, miR-296-5p and miR-1304-5p levels might be potential biomarkers for the prediction of the prognosis of DLBCL patients.
Short‐term reliability evaluation of integrated electricity and gas systems considering dynamics of gas flow
Authors: Wang Sheng , Ding Yi , Han Xiaoqing , Wang Peng , Goel Lalit , Ma Jien 
Published: June 2021

AbstractWith the adoption of gas‐fired units (GFU), the interaction between the electricity and gas systems has been intensified. The failure of the gas sources may lead to the insufficiency of the gas supply to the GFUs, and further result in the electricity supply shortage, threatening reliabilities of electricity and gas systems. However, compared with the electric power flow, the dynamics of the gas flow are much slower. Most of the existing studies evaluated the reliabilities of integrated electricity and gas systems (IEGS) without considering the slower dynamics of gas flow, which are not fully accurate in the short‐term. This paper proposes a short‐term reliability evaluation technique for IEGS considering the gas flow dynamics. Firstly, the short‐term reliability models of gas sources, GFUs, and gas compressors are developed. Then, the multi‐stage contingency management scheme is proposed, where gas flow dynamics are analysed for determining the time‐varying load curtailments of electricity and gas. Moreover, a time‐sequential Monte Carlo simulation technique is developed with the finite‐difference scheme to tackle the gas flow dynamics during the short‐term reliability evaluation. Finally, the proposed reliability evaluation technique is validated using an integrated IEEE reliability test system and the practical Belgium gas transmission system.
Electric field measurements at the plasma frequency around comet 67P by RPC-MIP on board Rosetta
Authors: Myllys M. , Henri P. , Vallières X. , Gilet N. , Nilsson H. , Palmerio E. , Turc L. , Wellbrock A. , Goldstein R. , Witasse O. 
Published: June 2021

Context. The Mutual Impedance Probe (RPC-MIP) carried by the Rosetta spacecraft monitored both the plasma density and the electric field in the close environment of comet 67P/Churyumov–Gerasimenko (67P), as the instrument was operating alternatively in two main modes: active and passive. The active mode is used primarily to perform plasma density measurements, while the passive mode enables the instrument to work as a wave analyzer.
Aims. We are reporting electric field emissions at the plasma frequency near comet 67P observed by RPC-MIP passive mode. The electric field emissions are related to Langmuir waves within the cometary ionized environment. In addition, this study gives feedback on the density measurement capability of RPC-MIP in the presence of cold electrons.
Methods. We studied the occurrence rate of the electric field emissions as well as their dependence on solar wind structures like stream interaction regions (SIRs) and coronal mass ejections (CMEs).
Results. We are showing that strong electric field emissions at the plasma frequency near 67P were present sporadically throughout the period when Rosetta was escorting the comet, without being continuous, as the occurrence rate is reported to be of about 1% of all the measured RPC-MIP passive spectra showing strong electric field emissions. The Langmuir wave activity monitored by RPC-MIP showed measurable enhancements during SIR or CME interactions and near perihelion.
Conclusions. According to our results, Langmuir waves are a common feature at 67P during the passage of SIRs. Comparing the plasma frequency given by the RPC-MIP passive mode during Langmuir wave periods with the RPC-MIP active mode observations, we conclude that the measurement accuracy of RPC-MIP depends on the operational submode when the cold electron component dominates the electron density.
The angular-momentum flux in the solar wind observed during Solar Orbiter’s first orbit
Authors: Verscharen Daniel , Stansby David , Finley Adam J. , Owen Christopher J. , Horbury Timothy , Maksimovic Milan , Velli Marco , Bale Stuart D. , Louarn Philippe , Fedorov Andrei , Bruno Roberto , Livi Stefano , Khotyaintsev Yuri V. , Vecchio Antonio , Lewis Gethyn R. , Anekallu Chandrasekhar , Kelly Christopher W. , Watson Gillian , Kataria Dhiren O. , O’Brien Helen , Evans Vincent , Angelini Virginia ,   the Solar Orbiter SWA, MAG and RPW teams
Published: June 2021

Aims.We present the first measurements of the angular-momentum flux in the solar wind recorded by the Solar Orbiter spacecraft. Our aim is to validate these measurements to support future studies of the Sun’s angular-momentum loss.Methods.We combined 60-min averages of the proton bulk moments and the magnetic field measured by the Solar Wind Analyser and the magnetometer onboard Solar Orbiter. We calculated the angular-momentum flux per solid-angle element using data from the first orbit of the mission’s cruise phase in 2020. We separated the contributions from protons and from magnetic stresses to the total angular-momentum flux.Results.The angular-momentum flux varies significantly over time. The particle contribution typically dominates over the magnetic-field contribution during our measurement interval. The total angular-momentum flux shows the largest variation and is typically anti-correlated with the radial solar-wind speed. We identify a compression region, potentially associated with a co-rotating interaction region or a coronal mass ejection, which leads to a significant localised increase in the angular-momentum flux, albeit without a significant increase in the angular momentum per unit mass. We repeated our analysis using the density estimate from the Radio and Plasma Waves instrument. Using this independent method, we find a decrease in the peaks of positive angular-momentum flux, but otherwise, our results remain consistent.Conclusions.Our results largely agree with previous measurements of the solar wind’s angular-momentum flux in terms of amplitude, variability, and dependence on radial solar-wind bulk speed. Our analysis highlights the potential for more detailed future studies of the solar wind’s angular momentum and its other large-scale properties with data from Solar Orbiter. We emphasise the need for studying the radial evolution and latitudinal dependence of the angular-momentum flux in combination with data from Parker Solar Probe and other assets at heliocentric distances of 1 au and beyond.
Comparison of Acceptance and Knowledge Transfer in Patient Information Before an MRI Exam Administered by Humanoid Robot Versus a Tablet Computer: A Randomized Controlled Study
Authors: Stoevesandt Dietrich , Jahn Patrick , Watzke Stefan , Wohlgemuth Walter A. , Behr Dominik , Buhtz Christian , Faber Irina , Enger Stephanie , Schwarz Karsten , Brill Richard 
Published: June 2021

Purpose To investigate whether a humanoid robot in a clinical radiological setting is accepted as a source of information in conversations before MRI examinations of patients. In addition, the usability and the information transfer were compared with a tablet.
Methods Patients were randomly assigned to a robot or tablet group with their consent prior to MRI. The usability of both devices was compared with the extended System Usability Scale (SUS) and the information transfer with a knowledge query. Reasons for refusal were collected by a non-responder questionnaire.
Results At the University Hospital Halle 117 patients were included for participation. There was no statistically significant difference in gender and age. Of 18 non-responders, 4 refused to participate partly because of the robot; for another 3 the reason could not be clarified. The usability according to SUS score was different with statistical significance between the groups in the mean comparison and was one step higher for the tablet on the adjective scale. There was no statistically significant difference in knowledge transfer. On average, 8.41 of 9 questions were answered correctly.
Conclusion This study is the first application, in a clinical radiological setting, of a humanoid robot interacting with patients. Tablet and robot are suitable for information transfer in the context of MRI. In comparison to studies in which the willingness to interact with a robot in the health care sector was investigated, the willingness is significantly higher in the present study. This could be explained by the fact that it was a concrete use case that was understandable to the participants and not a hypothetical scenario. Thus, potentially high acceptance for further specific areas of application of robots in radiology can be assumed. The higher level of usability perceived in the tablet group can be explained by the fact that here the interface represents a form of operation that has been established for years in all population groups. More frequent exposure to robots could also improve the response in the future.
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Der Chemokinrezeptor CXCR4 – seine Entwicklung und Bedeutung in der nuklearmedizinischen Theranostik
Authors: Bergner Carina , Gummesson Anja , Joksch Markus , Sarvestani Mohammadreza Kamali , von Helldorff Heike , Lapa Constantin , Krause Bernd J. , Schwarzenböck Sarah M. 
Published: June 2021

ZusammenfassungDer Chemokinrezeptor CXCR4 – häufig nachgewiesen, doch selten greifbar. Während in einer schier endlosen Zahl an Studien seine physiologische und pathogene Präsenz, seine zellulären Funktionen sowie Möglichkeiten seiner gezielten pharmakologischen Kontrolle seit fast 30 Jahren erforscht werden, ist das Spektrum seiner nuklearmedizinischen klinischen Anwendungen mit malignen Krankheitsbildern des hämatopoetischen Systems und einigen wenigen Entzündungsprozessen immer noch überschaubar. Das Verständnis um Prozesse, die seine dynamische Zelloberflächenexpression regulieren sowie die Suche nach selektiven Radiopharmaka zur Unterscheidung physiologischer von pathogenen CXCR4-Expressionen stellen die Herausforderung der Zukunft dar, um den CXCR4 als ein vielseitiges theranostisches Target in der Nuklearmedizin zu manifestieren.