bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on region selection super resolution restoration algorithm based on infrared micro-scanning optical imaging model
Authors: Chen Jian , Li Yan , Cao LiHua 
Published: February 2021

AbstractWith spring up of infrared imaging related industry, infrared imaging technology has become mainstream development direction of intelligent photoelectrical detection due to its good concealment, wide detection range, high positioning accuracy, long distant penetration, light weight, little volume, low power dissipation and high solidity. However, the features of infrared dim-small target image such as less details and low SNR become bottleneck of infrared image application. How to enhance imaging effect of infrared dim-small target becomes research hotspot. Starting from the point of ‘restoration as foundation’, the theory and technology of infrared dim-small target super-resolution restoration by utilizing the theory and technology of super-resolution restoration are explored in this paper. This paper mainly focuses on the research of super-resolution restoration algorithm of infrared dim-small target based on infrared micro-scanning optical model. Aiming at solving super-resolution restoration problem of infrared dim-small target, the traditional super-resolution restoration algorithm is optimized and the improved algorithm is proposed. Meanwhile, infrared micro-scanning optical model is introduced to break theoretical limit of simple image processing algorithm. And the performance of infrared image super-resolution restoration is improved.
Photocathodes beyond NiO: charge transfer dynamics in a π-conjugated polymer functionalized with Ru photosensitizers
Authors: Wahyuono Ruri A. , Seidler Bianca , Bold Sebastian , Dellith Andrea , Dellith Jan , Ahner Johannes , Wintergerst Pascal , Lowe Grace , Hager Martin D. , Wächtler Maria , Streb Carsten , Schubert Ulrich S. , Rau Sven , Dietzek Benjamin 
Published: February 2021

AbstractA conductive polymer (poly(p-phenylenevinylene), PPV) was covalently modified with RuII complexes to develop an all-polymer photocathode as a conceptual alternative to dye-sensitized NiO, which is the current state-of-the-art photocathode in solar fuels research. Photocathodes require efficient light-induced charge-transfer processes and we investigated these processes within our photocathodes using spectroscopic and spectro-electrochemical techniques. Ultrafast hole-injection dynamics in the polymer were investigated by transient absorption spectroscopy and charge transfer at the electrode–electrolyte interface was examined with chopped-light chronoamperometry. Light-induced hole injection from the photosensitizers into the PPV backbone was observed within 10 ps and the resulting charge-separated state (CSS) recombined within ~ 5 ns. This is comparable to CSS lifetimes of conventional NiO-photocathodes. Chopped-light chronoamperometry indicates enhanced charge-transfer at the electrode–electrolyte interface upon sensitization of the PPV with the RuII complexes and p-type behavior of the photocathode. The results presented here show that the polymer backbone behaves like classical molecularly sensitized NiO photocathodes and operates as a hole accepting semiconductor. This in turn demonstrates the feasibility of all-polymer photocathodes for application in solar energy conversion.
Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
Authors: Szabó Edit , Kulin Anna , Korányi László , Literáti-Nagy Botond , Cserepes Judit , Somogyi Anikó , Sarkadi Balázs , Várady György 
Published: February 2021

AbstractType 2 diabetes mellitus (T2DM) is one of the most common multifactorial diseases and several membrane transporters are involved in its development, complications and treatment. We have recently developed a flow-cytometry assay panel for the quantitative determination of red cell membrane protein levels with potential relevance in diseases. Here we report a detailed phenotypic analysis of a medium scale, clinically based study on the expression of T2DM-related membrane proteins, the GLUT1, GLUT3, MCT1, URAT1, ABCA1, ABCG2 and the PMCA4 transporters in erythrocytes. By comparing age-matched control subjects and three groups of T2DM patients (recently diagnosed, successfully managed, and patients with disease-related complications), we found significant differences in the membrane expression levels of the transporters in these groups. This is a first detailed analysis of T2DM related alterations in erythrocyte membrane transporter protein levels, and the results suggest significant changes in some of the transporter expression levels in various patient groups. By performing a further, more detailed analysis of the clinical and molecular biology parameters, these data may serve as a basis of establishing new, personalized diagnostic markers helping the prevention and treatment of type 2 diabetes.
Antibacterial FANA oligonucleotides as a novel approach for managing the Huanglongbing pathosystem
Authors: Sandoval-Mojica Andrés F. , Hunter Wayne B. , Aishwarya Veenu , Bonilla Sylvia , Pelz-Stelinski Kirsten S. 
Published: February 2021

AbstractCandidatus Liberibacter asiaticus (CLas), a bacterium transmitted by the Asian citrus psyllid, Diaphorina citri, is the causal agent of citrus greening disease, or Huanglongbng (HLB). Currently, vector population suppression with insecticides and tree removal are the most effective strategies for managing the HLB pathosystem. In this study, we assessed the bactericidal capabilities of 2′-deoxy-2′-fluoro-d-arabinonucleic acid antisense oligonucleotides (FANA ASO) both in vitro and in vivo by (1) confirming their capacity to penetrate insect cells, (2) silencing bacterial essential genes, and (3) quantifying reductions in bacterial titer and D. citri transmission. We confirmed that FANA ASO are able to penetrate insect cells without the use of a delivery agent. Expression of an essential gene in the D. citri endosymbiont, Wolbachia (wDi), significantly decreased by 30% following incubation with a wDi-specific FANA ASO. Viability of isolated wDi cells also decreased in response to the FANA ASO treatment. Delivery of a CLas-specific FANA ASO to infected adult D. citri in feeding assays resulted in significant silencing of a CLas essential gene. CLas relative density and transmission were significantly lower among D. citri fed FANA ASO in diet compared to untreated insects. Root infusions of a CLas-specific FANA ASO into infected Citrus trees significantly reduced CLas titer during a 30-day trial. Our results suggest that FANA ASO targeting insect-transmitted plant bacteria or insect endosymbionts may be useful tool for integrated management of agricultural pathogens.
Estimation of radiation dose from ingested tritium in humans by administration of deuterium-labelled compounds and food
Authors: Masuda Tsuyoshi , Yoshioka Toshitada 
Published: February 2021

AbstractRadiation doses from organically bound tritium (OBT) in foods have been a major concern near nuclear facilities. The current dose coefficient for OBT is calculated using a standard model from the International Commission on Radiological Protection, in which some biokinetic values are not based on human metabolic data. Here, the biokinetics of ingested OBT, and radiation doses from them, were estimated by administering labelled compounds and foods to volunteers, using a deuterium (D) tracer as a substitute for tritium. After the administration of D-labelled glucose, alanine, palmitic acid, or soybean, the D/H ratios in urine were measured for up to 119 days, and the biokinetic parameter values were determined for OBT metabolism. The slow degradation rates of OBT could not be obtained, in many volunteers administered glucose and alanine. The estimated committed effective dose for 1 Bq of tritium in palmitic acid varied from 3.2 × 10–11 to 3.5 × 10–10 Sv Bq−1 among volunteers and, for those administered soybean, it varied from 1.9 × 10–11 to 1.8 × 10–10 Sv Bq−1. These results suggest that OBT, present in some ingested ingredients, gives higher doses than the current dose coefficient value of 4.2 × 10–11 Sv Bq−1.
The brain dynamics of architectural affordances during transition
Authors: Djebbara Zakaria , Fich Lars Brorson , Gramann Klaus 
Published: February 2021

AbstractAction is a medium of collecting sensory information about the environment, which in turn is shaped by architectural affordances. Affordances characterize the fit between the physical structure of the body and capacities for movement and interaction with the environment, thus relying on sensorimotor processes associated with exploring the surroundings. Central to sensorimotor brain dynamics, the attentional mechanisms directing the gating function of sensory signals share neuronal resources with motor-related processes necessary to inferring the external causes of sensory signals. Such a predictive coding approach suggests that sensorimotor dynamics are sensitive to architectural affordances that support or suppress specific kinds of actions for an individual. However, how architectural affordances relate to the attentional mechanisms underlying the gating function for sensory signals remains unknown. Here we demonstrate that event-related desynchronization of alpha-band oscillations in parieto-occipital and medio-temporal regions covary with the architectural affordances. Source-level time–frequency analysis of data recorded in a motor-priming Mobile Brain/Body Imaging experiment revealed strong event-related desynchronization of the alpha band to originate from the posterior cingulate complex, the parahippocampal region as well as the occipital cortex. Our results firstly contribute to the understanding of how the brain resolves architectural affordances relevant to behaviour. Second, our results indicate that the alpha-band originating from the occipital cortex and parahippocampal region covaries with the architectural affordances before participants interact with the environment, whereas during the interaction, the posterior cingulate cortex and motor areas dynamically reflect the affordable behaviour. We conclude that the sensorimotor dynamics reflect behaviour-relevant features in the designed environment.
Interobserver variability in clinical target volume delineation in anal squamous cell carcinoma
Authors: Kim Kyung Su , Cheong Kwang-Ho , Kim Kyubo , Koo Taeryool , Koh Hyeon Kang , Chang Ji Hyun , Chang Ah Ram , Park Hae Jin 
Published: February 2021

AbstractWe evaluated the inter-physician variability in the target contouring of the radiotherapy for anal squamous cell carcinoma (ASCC). Clinical target volume (CTV) of three patients diagnosed with ASCC was delineated by seven experienced radiation oncologists from multi-institution. These patients were staged as pT1N1a, cT2N0, and cT4N1a, respectively, according to 8th edition of the American Joint Committee on Cancer staging system. Expert agreement was quantified using an expectation maximization algorithm for Simultaneous Truth and Performance Level Estimation (STAPLE). The maximum distance from the boundaries of the STAPLE generated volume with confidence level of 80% to those of the contour of each CTV in 6 directions was compared. CTV of pelvis which includes primary tumor, perirectal tissue and internal/external iliac lymph node (LN) area (CTV-pelvis) and CTV of inguinal area (CTV-inguinal) were obtained from the seven radiation oncologists. One radiation oncologist did not contain inguinal LN area in the treatment target volume of patient 2 (cT2N0 stage). CTV-inguinal displayed moderate agreement for each patient (overall kappa 0.58, 0.54 and 0.6, respectively), whereas CTV-pelvis showed substantial agreement (overall kappa 0.66, 0.68 and 0.64, respectively). Largest variation among each contour was shown in the inferior margin of the CTV-inguinal. For CTV-pelvis, anterior and superior margin showed the biggest variation. Overall, moderate to substantial agreement was shown for CTV delineation. However, large variations in the anterior and cranial boarder of the CTV-pelvis and the caudal margin of the CTV-inguinal suggest that further studies are needed to establish a clearer target volume delineation guideline.
Terahertz characterization of two-dimensional low-conductive layers enabled by metal gratings
Authors: Gopalan Prashanth , Wang Yunshan , Sensale-Rodriguez Berardi 
Published: February 2021

AbstractWhile terahertz spectroscopy can provide valuable information regarding the charge transport properties in semiconductors, its application for the characterization of low-conductive two-dimensional layers, i.e., σs <  < 1 mS, remains elusive. This is primarily due to the low sensitivity of direct transmission measurements to such small sheet conductivity levels. In this work, we discuss harnessing the extraordinary optical transmission through gratings consisting of metallic stripes to characterize such low-conductive two-dimensional layers. We analyze the geometric tradeoffs in these structures and provide physical insights, ultimately leading to general design guidelines for experiments enabling non-contact, non-destructive, highly sensitive characterization of such layers.
DeePaN: deep patient graph convolutional network integrating clinico-genomic evidence to stratify lung cancers for immunotherapy
Authors: Fang Chao , Xu Dong , Su Jing , Dry Jonathan R , Linghu Bolan 
Published: February 2021

AbstractImmuno-oncology (IO) therapies have transformed the therapeutic landscape of non-small cell lung cancer (NSCLC). However, patient responses to IO are variable and influenced by a heterogeneous combination of health, immune, and tumor factors. There is a pressing need to discover the distinct NSCLC subgroups that influence response. We have developed a deep patient graph convolutional network, we call “DeePaN”, to discover NSCLC complexity across data modalities impacting IO benefit. DeePaN employs high-dimensional data derived from both real-world evidence (RWE)-based electronic health records (EHRs) and genomics across 1937 IO-treated NSCLC patients. DeePaN demonstrated effectiveness to stratify patients into subgroups with significantly different (P-value of 2.2 × 10−11) overall median survival of 20.35 months and 9.42 months post-IO therapy. Significant differences in IO outcome were not seen from multiple non-graph-based unsupervised methods. Furthermore, we demonstrate that patient stratification from DeePaN has the potential to augment the emerging IO biomarker of tumor mutation burden (TMB). Characterization of the subgroups discovered by DeePaN indicates potential to inform IO therapeutic insight, including the enrichment of mutated KRAS and high blood monocyte count in the IO beneficial and IO non-beneficial subgroups, respectively. Our work has proven the concept that graph-based AI is feasible and can effectively integrate high-dimensional genomic and EHR data to meaningfully stratify cancer patients on distinct clinical outcomes, with potential to inform precision oncology.
Multi‐channel underdetermined blind source separation for recorded audio mixture signals using an unmanned aerial vehicle
Authors: Xie Kan , Jiang Kanyang , Yang Qiyu 
Published: February 2021

AbstractUnmanned aerial vehicles as an important role for 5G and beyond networks are becoming more and more popular and have been equipped with various sensors to enable diverse emerging applications, e.g. locating sound‐emitting targets. Multi‐channel blind source separation algorithm has been applied into the unmanned aerial vehicles and micro aerial vehicles, where underdetermined mixture blind source separation is a challenging problem, i.e. the number of sources is more than the number of microphones. An optimization underdetermined blind source separation algorithm to separate the multi‐channel audio mixture signals recorded by an unmanned aerial vehicle is proposed. In the algorithm, firstly a hierarchical clustering to estimate channel as the mixing matrix initialization is employed, while using direction of arrival permutation algorithm to deal with the permutation alignment and update the mixing matrix using multiplication update method. Then the model parameters are estimated using improved expectation‐maximization update rules for the fast convergence. Finally, the frequency‐domain sources are estimated through Wiener filtering and time‐domain sources are obtained via inverse short‐time Fourier transform. Experimental results covering synthetic and real‐recorded speech source mixtures show that the proposed algorithm achieves better separation results than the state‐of‐the‐art methods.
Metaheuristic‐based optimal 3D positioning of UAVs forming aerial mesh network to provide emergency communication services
Authors: Gupta Manali , Varma Shirshu 
Published: February 2021

AbstractThe optimal placement of unmanned aerial vehicles (UAVs) to facilitate post‐disaster emergency communication services is a paramount research domain. The novelty of the authors’ work is to optimally place available UAVs in 3D space to meet the objectives prominent during such situations. The objectives considered here are target coverage, QoS, energy consumption and two newly characterized objectives, i.e. equal load distribution over UAVs and fault tolerance for improving network connectivity and lifetime. To improve these conflicting objectives altogether, the authors proposed two metaheuristic‐based hybrid optimization algorithms, namely, HWWO‐HSA, a hybrid of Water Wave Optimization (WWO), Harmony Search (HS) and Simulated Annealing (SA); and HGA‐SA, a hybrid of Genetic Algorithm (GA) and SA. Furthermore, to improve network performance, the authors performed their parameter tuning using well‐known Taguchi's design of experiment. For maintaining network connectivity, the authors used the concept of graphs for connected components. The proposed hybrids are compared with their originals, i.e. GA, HS, SA and WWO over different scaled test scenarios. The non‐parametric Kruskal–Wallis test and Dunn's post hoc test suggest that hybrids perform better than the originals. HGA‐SA significantly outperforms in small‐scale scenarios while HWWO‐HSA significantly outperforms in medium‐scale and large‐scale scenarios. However, being hybrid the computational time of the hybrids is greater than the originals.
Intravesikale Gemcitabin-Instillationstherapie bei BCG-Versagen und Mitomycin-Allergie – Der besondere Fall einer Patientin mit invertiertem Papillom der Harnblase
Authors: Matzen Merle , Offermann Anne , Tharun Lars , Perner Sven , Merseburger Axel S. , Kramer Mario , Hupe Marie Christine 
Published: February 2021

ZusammenfassungDie Instillationstherapie stellt im Feld der urothelialen Neoplasien der Harnblase eine einzigartige Therapiemöglichkeit dar, die so in keinem anderen medizinischen Bereich zur Anwendung kommt. Mit der Wahl des zu instillierenden Medikamentes hat sich die Forschung der vergangenen Jahre intensiv beschäftigt, hierbei hat sich besonders der Einsatz von Bacillus Calmette-Guerin (BCG) und Mitomycin C (MMC) bewährt. Weitere Medikamente, die jedoch seltener zum Einsatz kommen, sind Chemotherapeutika wie Gemcitabin, dessen klinische Relevanz in diesem Artikel beleuchtet werden soll.So vielfältig, wie die Therapiemöglichkeiten der Harnblasentumore, ist auch ihre Histopathologie. Das invertierte Papillom stellt im Formenkreis der urologischen Erkrankungen eine seltene Krankheitsentität dar. Eine Assoziation zum nicht-muskelinvasiven Harnblasenkarzinom wird diskutiert.Wir berichten von dem Fall einer Patientin mit invertiertem Papillom der Harnblase, welche nach Versagen einer BCG-Therapie und einer allergischen Reaktion gegen MMC mit einer Gemcitabin-Instillationstherapie behandelt wurde.
Adenoma detection by Endocuff-assisted versus standard colonoscopy in an organized screening program: the “ItaVision” randomized controlled trial
Authors: Zorzi Manuel , Hassan Cesare , Battagello Jessica , Antonelli Giulio , Pantalena Maurizio , Bulighin Gianmarco , Alicante Saverio , Meggiato Tamara , Rosa-Rizzotto Erik , Iacopini Federico , Luigiano Carmelo , Monica Fabio , Arrigoni Arrigo , Germanà Bastianello , Valiante Flavio , Mallardi Beatrice , Senore Carlo , Grazzini Grazia , Mantellini Paola ,   and the ItaVision Working Group
Published: February 2021

Abstract
Background The Endocuff Vision device (Arc Medical Design Ltd., Leeds, UK) has been shown to increase mucosal exposure, and consequently adenoma detection rate (ADR), during colonoscopy. This nationwide multicenter study assessed possible benefits and harms of using Endocuff Vision in a fecal immunochemical test (FIT)-based screening program.
Methods Patients undergoing colonoscopy after a FIT-positive test were randomized 1:1 to undergo Endocuff-assisted colonoscopy or standard colonoscopy, stratified by sex, age, and screening history. Primary outcome was ADR. Secondary outcomes were ADR stratified by endoscopists’ ADR, advanced ADR (AADR), adenomas per colonoscopy (APC), withdrawal time, and adverse events.
Results 1866 patients were enrolled across 13 centers. After exclusions, 1813 (mean age 60.1 years; male 53.8 %) were randomized (908 Endocuff Vision, 905 standard colonoscopy). ADR was significantly higher in the Endocuff Vision arm (47.8 % vs. 40.8 %; relative risk [RR] 1.17, 95 % confidence interval [CI] 1.06–1.30), with no differences between arms regarding size or morphology. When stratifying for endoscopists’ ADR, only low detectors (ADR < 33.3 %) showed a statistically significant ADR increase (Endocuff Vision 41.1 % [95 %CI 35.7–46.7] vs. standard colonoscopy 26.0 % [95 %CI 21.3–31.4]). AADR (24.8 % vs. 20.5 %, RR 1.21, 95 %CI 1.02–1.43) and APC (0.94 vs. 0.77; P  = 0.001) were higher in the Endocuff Vision arm. Withdrawal time and adverse events were similar between arms.
Conclusion Endocuff Vision increased ADR in a FIT-based screening program by improving examination of the whole colonic mucosa. Utility was highest among endoscopists with a low ADR.
Development of a Continuous Photochemical Benzyne-Forming Process
Authors: Baumann Marcus , Bracken Cormac , Batsanov Andrei S. 
Published: February 2021

AbstractA continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow process effectively controls the release of gaseous by-products based on an adjustable backpressure regulator and delivers a series of heterocyclic products in a short residence time of 3 minutes. The robustness of this methodology is demonstrated for the rapid generation of benzotriazoles, 2H-indazoles and various furan-derived adducts, facilitating the preparation of these important heterocyclic scaffolds via a simple and readily scalable flow protocol.
4-Cyano-3-oxotetrahydrothiophene (c-THT): An Ideal Acrylonitrile Anion Equivalent
Authors: Arseniyadis Stellios , Richard François , Mateos Carlos 
Published: February 2021

Abstract4-Cyano-3-oxotetrahydrothiophene (c-THT) has much more to offer than just a platform to various heterocyclic scaffolds. This solid, bench-stable and commercially available reagent can be readily transformed into thioglycolic acid and acrylonitrile upon simple addition of a hydroxide anion. This interesting feature enables its use as a particularly versatile acrylonitrile anion surrogate.