bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internal Solitary Waves in the Andaman Sea Revealed by Long-Term Mooring Observations
Authors: Yang Yunchao , Huang Xiaodong , Zhao Wei , Zhou Chun , Huang Siwei , Zhang Zhiwei , Tian Jiwei 
Published: October 2021

AbstractThe complex behaviors of internal solitary waves (ISWs) in the Andaman Sea were revealed using data collected over a nearly 22-month-long observation period completed by two moorings. Emanating from the submarine ridges northwest of Sumatra Island and south of Car Nicobar, two types of ISWs, referred to as S- and C-ISWs, respectively, were identified in the measurements, and S-ISWs were generally found to be stronger than C-ISWs. The observed S- and C-ISWs frequently appeared as multiwave packets, accounting for 87% and 43% of their observed episodes, respectively. The simultaneous measurements collected by the two moorings featured evident variability along the S-ISW crests, with the average wave amplitude in the northern portion being 36% larger than that in the southern portion. The analyses of the arrival times revealed that the S-ISWs in the northern portion occurred more frequently and arrived more irregularly than those in the southern portion. Moreover, the temporal variability of ISWs drastically differed on monthly and seasonal time scales, characterized by relatively stronger S-ISWs in spring and autumn. Over the interannual time scale, the temporal variations in ISWs were generally subtle. The monthly-to-annual variations of ISWs could be mostly explained by the variability in stratification, which could be modulated by the monsoons, the winds in equatorial Indian Ocean, and the mesoscale eddies in the Andaman Sea. From careful analyses preformed based on the long-term measurements, we argued that the observed ISWs were likely generated via internal tide release mechanism and their generation processes were obviously modulated by background circulations.
The value of weather and climate information to the Tanzanian disaster risk reduction sector using non-monetary approaches
Authors: Msemo Hellen E. , Taylor Andrea L. , Birch Cathryn E. , Dougill Andrew J. , Hartley Andrew 
Published: October 2021

AbstractThis paper investigates the value of weather and climate information at different timescales for decision making in the Tanzanian disaster risk reduction sector using non-monetary approaches. Interviews and surveys were conducted with institutions responsible for disaster management at national, regional and district level. A range of values were identified including: 1) making informed decisions for disaster preparedness, response, recovery and restoration related activities; 2) tailoring of directives and actions based on sectoral impacts; 3) identification of hotspot areas for diseases outbreaks and surplus food production. However, while, a number of guidelines, policies, acts and regulations for disaster risk reduction exist it is not clear how well they promote the use of weather and climate information across climate sensitive sectors. Nonetheless, we find that well-structured disaster risk reduction coordination across sectors and institutions from the national to district level exists, although there is a need for further development of integrated Early Warning Systems, and a common platform to evaluate effectiveness and usefulness of weather warnings and advisories. Key challenges to address in increasing the uptake of weather warnings and advisories include language barriers, limited dissemination to rural areas, and limited awareness of forecasts. Based on the findings of this study, we recommend further quantitative evaluation of the skill of the severe weather warnings issued by the Tanzania Meteorological Authority, and an assessment of how decisions and actions are made by recipients of the warnings in the disaster risk reduction sector at different stages in the warning, response and recovery process.
Use of Chimney Technique Does Not Improve the Outcome of Endovascular Aneurysm Repair in Patients With a Hyperangulated and Short Proximal Aortic Neck
Authors: Özdemir-van Brunschot Denise Michelle Daniëlle , Torsello Giovanni Battista , Bernardini Giulia , Litterscheid Sarah , Torsello Giovanni Federico , Beropoulis Efthymios 
Published: October 2021

Purpose: We hypothesized that extending the proximal landing zone with the chimney technique could be beneficial in patients with a hyperangulated proximal aortic neck, defined as more > 60 degrees. Material and Methods: We retrospectively analyzed the outcome of prospectively collected data of patients treated by endovascular aneurysm repair (EVAR) for infrarenal aortic aneurysm with a hyperangulated proximal aortic neck. In all, 104 out of 130 patients were treated without (Group A) and 24 with the chimney endovascular aortic repair (ChEVAR, Group B). Primary outcome was technical and clinical success according to the reporting standards of the Society of Vascular Surgery. Results: The use of the chimney technique was associated with a significantly longer operation duration (167 vs. 93 min, p < .001), longer fluoroscopy time (44 vs.30 min, p = < .001), and larger amount of contrast medium used (149 vs. 127 ml, p = .03) but did not significantly improve technical (79.2% vs. 87.7%) and clinical success (54.2% vs. 68.9%). Aneurysm-related mortality was higher in group B (8.3% vs. = 0%, p < .001). Type IA endoleak was high in both groups at completion angiography (11.3% in Group A vs. 12.5% in Group B) and at follow-up (10.4% in Group A vs. 4.5% in Group B) without significant difference between the groups. Conclusions: Our data did not show a benefit of the primary use of the chimney technique in patients with a hyperangulated and short neck, although more studies are required to support this conclusion. Other strategies or new technologies are required for improving EVAR results in aneurysm patients with severe angulated proximal and short neck.
Effect of Training With the Hybrid Assistive Limb on Gait Cycle Kinematics After Total Knee Arthroplasty
Authors: Fukaya Takashi , Mutsuzaki Hirotaka , Yoshikawa Kenichi , Koseki Kazunori , Iwai Koichi 
Published: October 2021

Introduction Reportedly, wearable robots, such as the hybrid assistive limb (HAL), are effective in the functional recovery of various locomotor disabilities, including disrupted walking, restricted range of motion, and muscle weakness. However, the effect of walking exercises with a HAL on the kinematic and kinetic variables of lower limb joint function is not yet fully understood. Therefore, the purpose of this study was to elucidate the effect of HAL on the kinematic and kinetic variables of lower limb function in patients 5 weeks after total knee arthroplasty (TKA). Materials and Methods Nine patients (ten knees) in the HAL training group and nine patients (nine knees) in the control group underwent TKA. HAL training was initiated 1–5 weeks after TKA, and general rehabilitation was performed in the control group. Gait analysis was performed on each patient using a motion analysis system at 5 weeks after TKA. We compared the effects of the joint angles of the walking cycle between groups, and investigated the effect of the walking cycle’s joint angles on step length. Results In the HAL group, the odds ratio of hip extension was as large as 1.741, while that of knee swing was as large as 1.501. These 2 variables were significant between the 2 groups. Knee swing and varus significantly affected step length. Conclusions Our results suggest that training by wearing HAL after TKA increased the mobility of the knee and hip joints during early postoperative walking, and that walking ability was improved by increasing the step length.
Anticoagulation targeting membrane-bound anionic phospholipids improves outcomes of traumatic brain injury in mice
Authors: Dong Xinlong , Liu Wei , Shen Yu , Houck Katie , Yang Mengchen , Zhou Yuan , Zhao Zilong , Wu Xiaoping , Blevins Teri , Koehne Amanda L. , Wun Tze-Chein , Fu Xiaoyun , Li Min , Zhang Jianning , Dong Jing-fei 
Published: October 2021

AbstractSevere traumatic brain injury (TBI) often causes an acute systemic hypercoagulable state that rapidly develops into consumptive coagulopathy. We have recently demonstrated that TBI-induced coagulopathy (TBI-IC) is initiated and disseminated by brain-derived extracellular vesicles (BDEVs) and propagated by extracellular vesicles (EVs) from endothelial cells and platelets. Here, we present results from a study designed to test the hypothesis that anticoagulation targeting anionic phospholipid-expressing EVs prevents TBI-IC and improves the outcomes of mice subjected to severe TBI. We evaluated the effects of a fusion protein (ANV-6L15) for improving the outcomes of TBI in mouse models combined with in vitro experiments. ANV-6L15 combines the phosphatidylserine (PS)-binding annexin V (ANV) with a peptide anticoagulant modified to preferentially target extrinsic coagulation. We found that ANV-6L15 reduced intracranial hematoma by 70.2%, improved neurological function, and reduced death by 56.8% in mice subjected to fluid percussion injury at 1.9 atm. It protected the TBI mice by preventing vascular leakage, tissue edema, and the TBI-induced hypercoagulable state. We further showed that the extrinsic tenase complex was formed on the surfaces of circulating EVs, with the highest level found on BDEVs. The phospholipidomic analysis detected the highest levels of PS on BDEVs, as compared with EVs from endothelial cells and platelets (79.1, 15.2, and 3.5 nM/mg of protein, respectively). These findings demonstrate that TBI-IC results from a trauma-induced hypercoagulable state and may be treated by anticoagulation targeting on the anionic phospholipid-expressing membrane of EVs from the brain and other cells.
Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study
Authors: Sun Yang , Xia Peng-Fei , Xie Jing , Mustieles Vicente , Zhang Yu , Wang Yi-Xin , Messerlian Carmen 
Published: October 2021

BackgroundPopulation studies show that the use of swimming pools is associated with the risk of asthma and allergic diseases among children. Our objective was to explore the associations between blood trihalomethane (THM) concentrations and asthma among US adolescents, and assess to what extent the association is modified by active tobacco smoke exposure.MethodsWe included 2359 adolescents aged 12–19 years with measured blood concentrations of chloroform (trichloromethane (TCM)), bromodichloromethane (BDCM), dibromochloromethane (DBCM) and bromoform (tribromomethane (TBM)) from the National Health and Nutrition Examination Survey 2005–2012. Logistic regression models were fitted to assess the odds ratios for the association of blood THM concentrations (three or four categories) with the risk of self-reported current and ever (lifetime) asthma.ResultsBlood DBCM concentrations were associated with a higher risk of ever asthma among all adolescents (OR 1.54 (95% CI 1.07–2.21), comparing the extreme exposure categories). The relationship was stronger among adolescents exposed to tobacco smoke (OR 3.96 (95% CI 1.89–8.30), comparing the extreme exposure categories). We also found positive relationships between blood brominated THM concentrations (sum of BDCM, DBCM and TBM) and risk of ever asthma and between blood DBCM and brominated THM concentrations and risk of current asthma among adolescents with tobacco smoke exposure. The relative excess risk of ever asthma due to the interaction between high blood DBCM and brominated THM concentrations and tobacco smoke exposure was 1.87 (95% CI 0.30–3.43) and 0.78 (95% CI 0.07–1.49), respectively.ConclusionsExposure to THMs is associated with a higher risk of asthma in adolescents, particularly among those exposed to tobacco smoke.
Guide sheathversusnon-guide sheath method for endobronchial ultrasound-guided biopsy of peripheral pulmonary lesions: a multicentre randomised trial
Authors: Oki Masahide , Saka Hideo , Imabayashi Tatsuya , Himeji Daisuke , Nishii Yoichi , Nakashima Harunori , Minami Daisuke , Okachi Shotaro , Mizumori Yasuyuki , Ando Masahiko 
Published: October 2021

BackgroundGuide sheaths (GSs) have been widely used during radial probe endobronchial ultrasound-guided transbronchial biopsy (rEBUS-TBB) of peripheral pulmonary lesions. However, it remains unknown whether a GS enhances the diagnostic yield. We compared the diagnostic yields of small peripheral pulmonary lesions between rEBUS-TBB with and without a GS.MethodsIn eight institutions, patients with peripheral pulmonary lesions ≤30 mm in diameter were enrolled and randomised to undergo rEBUS-TBB with a GS (GS group) or without a GS (non-GS group) using a 4.0-mm thin bronchoscope, virtual bronchoscopic navigation and fluoroscopy. The primary end-point was the diagnostic yield of the histology specimens.ResultsA total of 605 patients were enrolled; ultimately, data on 596 (300 in the GS group and 296 in the non-GS group) with peripheral pulmonary lesions having a longest median diameter of 19.6 mm were analysed. The diagnostic yield of histological specimens from the GS group was significantly higher than that from the non-GS group (55.3%versus46.6%; p=0.033). Interactions were evident between the diagnostic yields, procedures, lobar locations (upper lobeversusother regions; p=0.003) and lesion texture (solidversuspart-solid nodules; p=0.072).ConclusionsThe diagnostic yield for small peripheral pulmonary lesions afforded by rEBUS-TBB using a GS was higher than that without a GS.
Nestin promotes pulmonary fibrosisviafacilitating recycling of TGF-β receptor I
Authors: Wang Jiancheng , Lai Xiaofan , Yao Senyu , Chen Hainan , Cai Jianye , Luo Yulong , Wang Yi , Qiu Yuan , Huang Yinong , Wei Xiaoyue , Wang Boyan , Lu Qiying , Guan Yuanjun , Wang Tao , Li Shiyue , Xiang Andy Peng 
Published: October 2021

BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that is characterised by aberrant proliferation of activated myofibroblasts and pathological remodelling of the extracellular matrix. Previous studies have revealed that the intermediate filament protein nestin plays key roles in tissue regeneration and wound healing in different organs. Whether nestin plays a critical role in the pathogenesis of IPF needs to be clarified.MethodsNestin expression in lung tissues from bleomycin-treated mice and IPF patients was determined. Transfection with nestin short hairpin RNA vectorsin vitrothat regulated transcription growth factor (TGF)-β/Smad signalling was conducted. Biotinylation assays to observe plasma membrane TβRI, TβRI endocytosis and TβRI recycling after nestin knockdown were performed. Adeno-associated virus serotype (AAV)6-mediated nestin knockdown was assessedin vivo.ResultsWe found that nestin expression was increased in a murine pulmonary fibrosis model and IPF patients, and that the upregulated protein primarily localised in lung α-smooth muscle actin-positive myofibroblasts. Mechanistically, we determined that nestin knockdown inhibited TGF-β signalling by suppressing recycling of TβRI to the cell surface and that Rab11 was required for the ability of nestin to promote TβRI recycling.In vivo, we found that intratracheal administration of AAV6-mediated nestin knockdown significantly alleviated pulmonary fibrosis in multiple experimental mice models.ConclusionOur findings reveal a pro-fibrotic function of nestin partially through facilitating Rab11-dependent recycling of TβRI and shed new light on pulmonary fibrosis treatment.
COPD mortality and exacerbations in the placebo group of clinical trials over two decades: a systematic review and meta-regression
Authors: Andreas Stefan , Röver Christian , Heinz Judith , Taube Christian , Friede Tim 
Published: October 2021

A decreasing trend in exacerbation rates has been observed in COPD. Because mortality is linked to exacerbations, it is of interest to investigate whether a similar time trend is also present in mortality rates.We performed a systematic review of placebo groups in published randomised controlled trials. Mortality rate was modelled based on a Poisson distribution for the event counts. Adding information on mortality as well as on newly published studies on a previous database, we performed a meta-regression.Among the 56 included studies representing 14 166 patients, an annual decrease in mortality rates of 6.1% (−0.6%, 12.6%) (p=0.073) was observed. Consistent results were obtained in subgroups as well as when adjusting for potential confounders. The correlation between exacerbation rate and mortality rate was positive but weak as well as insignificant.In summary, analysis of randomised controlled trials in COPD patients showed a decrease in mortality in the placebo arms over the last two decades. This effect is comparable to the previously observed decrease in annual exacerbation rate. Albeit insignificant, our results suggest that care is needed in the design of new trials or when comparing results from trials published many years apart.
Methodological dualism considered as a heuristic paradigm for clinical psychiatry
Authors: Pernu Tuomas K. 
Published: October 2021

SUMMARYDebates on dualism continue to plague psychiatry. I suggest that these debates are based on false dichotomies. According to metaphysical physicalism, reality is ultimately physical. Although this view excludes the idea of entities distinct from physical reality, it does not compel us to favour neural over psychological interventions. According to methodological dualism, both physical and mental interventions on the world can be deemed effective, and both perspectives can therefore be thought to be equally ‘real’.
Neuromuscular Disorders in the Intensive Care Unit
Authors: Birch Torrey Boland 
Published: October 2021

ABSTRACT

PURPOSE OF REVIEW
This article discusses the pathophysiology, presentation, diagnosis, treatment, and prognosis of common neuromuscular disorders seen in the intensive care unit, including Guillain-Barré syndrome, myasthenia gravis, and intensive care unit–acquired weakness.

RECENT FINDINGS
Guillain-Barré syndrome can have an excellent prognosis if patients are diagnosed early, appropriately treated, and monitored for complications, including respiratory failure and dysautonomia. Intensive care unit–acquired weakness increases overall mortality in patients who are critically ill, and distinguishing between critical illness myopathy and critical illness polyneuropathy may have important prognostic implications.

SUMMARY
Neuromuscular disorders are not rare in the intensive care unit setting, and precise identification and treatment of these conditions can greatly impact long-term outcomes.
Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit
Authors: Rosenthal Eric S. 
Published: October 2021

ABSTRACT

PURPOSE OF REVIEW
This article discusses the evolving definitions of seizures and status epilepticus in the critical care environment and the role of critical care EEG in both diagnosing seizure activity and serving as a predictive biomarker of clinical trajectory.

RECENT FINDINGS
Initial screening EEG has been validated as a tool to predict which patients are at risk of future seizures. However, accepted definitions of seizures and nonconvulsive status epilepticus encourage a treatment trial when the diagnosis on EEG is indeterminate because of periodic or rhythmic patterns or uncertain clinical correlation. Similarly, recent data have demonstrated the diagnostic utility of intracranial EEG in increasing the yield of seizure detection. EEG has additionally been validated as a diagnostic biomarker of covert consciousness, a predictive biomarker of cerebral ischemia and impending neurologic deterioration, and a prognostic biomarker of coma recovery and status epilepticus resolution. A recent randomized trial concluded that patients allocated to continuous EEG had no difference in mortality than those undergoing intermittent EEG but could not demonstrate whether this lack of difference was because of studying heterogeneous conditions, examining a monitoring tool rather than a therapeutic approach, or examining an outcome measure (mortality) perhaps more strongly associated with early withdrawal of life-sustaining therapy than to a sustained response to pharmacotherapy.

SUMMARY
Seizures and status epilepticus are events of synchronous hypermetabolic activity that are either discrete and intermittent or, alternatively, continuous. Seizures and status epilepticus represent the far end of a continuum of ictal-interictal patterns that include lateralized rhythmic delta activity and periodic discharges, which not only predict future seizures but may be further classified as status epilepticus on the basis of intracranial EEG monitoring or a diagnostic trial of antiseizure medication therapy. In particularly challenging cases, neuroimaging or multimodality neuromonitoring may be a useful adjunct documenting metabolic crisis. Specialized uses of EEG as a prognostic biomarker have emerged in traumatic brain injury for predicting language function and covert consciousness, cardiac arrest for predicting coma recovery, and subarachnoid hemorrhage for predicting neurologic deterioration due to delayed cerebral ischemia.
Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages
Authors: Bando Tetsuya , Okumura Misa , Bando Yuki , Hagiwara Marou , Hamada Yoshimasa , Ishimaru Yoshiyasu , Mito Taro , Kawaguchi Eri , Inoue Takeshi , Agata Kiyokazu , Noji Sumihare , Ohuchi Hideyo 
Published: October 2021

ABSTRACT
Hemimetabolous insects, such as the two-spotted cricket Gryllus bimaculatus, can recover lost tissues, in contrast to the limited regenerative abilities of human tissues. Following cricket leg amputation, the wound surface is covered by the wound epidermis, and plasmatocytes, which are insect macrophages, accumulate in the wound region. Here, we studied the function of Toll-related molecules identified by comparative RNA sequencing during leg regeneration. Of the 11 Toll genes in the Gryllus genome, expression of Toll2-1, Toll2-2 and Toll2-5 was upregulated during regeneration. RNA interference (RNAi) of Toll, Toll2-1, Toll2-2, Toll2-3 or Toll2-4 produced regeneration defects in more than 50% of crickets. RNAi of Toll2-2 led to a decrease in the ratio of S- and M-phase cells, reduced expression of JAK/STAT signalling genes, and reduced accumulation of plasmatocytes in the blastema. Depletion of plasmatocytes in crickets using clodronate also produced regeneration defects, as well as fewer proliferating cells in the regenerating legs. Plasmatocyte depletion also downregulated the expression of Toll and JAK/STAT signalling genes in the regenerating legs. These results suggest that Spz-Toll-related signalling in plasmatocytes promotes leg regeneration through blastema cell proliferation by regulating the Upd-JAK/STAT signalling pathway.