bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key Gene Network Related to Primary Ciliary Dyskinesia in Hippocampus of Patients With Alzheimer’s Disease Revealed by Weighted Gene Co-expression Network Analysis
Authors: Xia Pengcheng , Chen Jing , Bai Xiaohui , Li Ming , Wang Le , Lu Zhiming 
Published: October 2021

Abstract
Background. Alzheimer's disease (AD) is closely related to aging, showing an increasing incidence rate for years. As one of the main organs involved in AD, hippocampus has been extensively studied due to its association with many human diseases. However, little knowledge is known on its association with primary ciliary dyskinesia (PCD).Material and Methods. The microarray data of hippocampus on AD were retrieved from the Gene Expression Omnibus (GEO) database to construct the co-expression network by weighted gene co-expression network analysis (WGCNA). The gene network modules associated with AD screened with the common genes were further annotated based on Gene Ontology (GO) database and enriched based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. The protein-protein interaction (PPI) network was constructed based on STRING database to identify the hub genes in the network.Results. Genes involved in PCD were identified in the hippocampus of AD patients. Functional analysis revealed that these genes were mainly enriched in ciliary tissue, ciliary assembly, axoneme assembly, ciliary movement, microtubule based process, microtubule based movement, organelle assembly, axoneme dynamin complex, cell projection tissue, and microtubule cytoskeleton tissue. A total of 20 central genes, e.g.,DYNLRB2, ZMYND10, DRC1, DNAH5, WDR16, TTC25, and ARMC4 were identified as hub genes related to PCD in hippocampus of AD patients.Conclusion. Our study demonstrated that AD and PCD have shared metabolic pathways. These common pathways provide novel evidence for further investigation of the pathophysiological mechanism and the hub genes suggest new therapeutic targets for the diagnosis and treatment of AD and PCD.Subjects Bioinformatics, Cell Biology, Molecular Biology, Neurology
The Effect of Apolipoprotein E Gene Polymorphism and Lp (a) Levels on Coronary Artery Disease with Atrial Fibrillation
Authors: Li Yong , Chen Lei , Zhang Min , Chen Wensu 
Published: October 2021

Abstract
Background This study is the first to explore the influence of the apolipoprotein E gene (APOE) and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation.Methods In this study, there were a total of 2048 participants, including 400 patients in the control group (CAD- AF-), 126 AF patients without CAD (CAD- AF+), 1294 CAD patients without AF (CAD+ AF-) and 228 CAD patients with AF (CAD+ AF+). Blood lipid levels and APOE genotypes were determined by collecting blood samples from the patients.Results Compared with CAD patients without AF, the age and Lp (a) levels of CAD patients with AF were significantly higher. Among CAD patients, the frequencies of E3/E3 and ε3 genotypes in patients with AF were significantly lower than those in patients without AF, and the frequencies of E4/E4 and ε4 genotypes were significantly increased. Spearman correlation analysis showed that in CAD patients, Lp(a) levels in the ε4 group were significantly higher than those in the group of patients without ε4, and there was a significant correlation between ε4 and Lp (a) levels (p<0.001, r=0.106). Multivariate logistic regression analysis found that the increase in Lp (a) levels (p=0.023) and age (p=0.01) were independent risk factors for CAD patients who develop AF.Conclusion Patients with AF had increased age, ε4 frequencies and Lp (a) levels among CAD patients, age and Lp (a) levels may be independent risk factors for CAD patients to develop AF.
Correlación del deseo sexual y disposición a fantasías sexuales con control inhibitorio y planificación cognitiva en jóvenes colombianos
Authors: Klimenko Olena , Cardona Restrepo Brigitte Natalia , Navarro Mercado María Monica 
Published: October 2021

Objetivo: El estudio se orientó a indagar la relación entre algunas funciones ejecutivas (FE) (control inhibitorio, cálculo de riesgo-beneficio, flexibilidad cognitiva, habilidad de planeación y toma de decisiones) con el deseo sexual general, diádico y solitario, inhibición del deseo sexual y disposición hacia las fantasías sexuales en una muestra de jóvenes entre 17 y 30 años. Método: Estudio de enfoque cuantitativo de corte transversal. Mediante un muestreo intencional por conveniencia se seleccionaron 64 jóvenes entre 17 y 30 años, estudiantes universitarios que se encontraban en una relación de pareja. Para evaluar las variables de las FE se utilizaron tareas de la Batería Neuropsicológica de Funciones Ejecutivas y Lóbulos Frontales (BANFE): Stroop, juego de cartas, clasificación de cartas y Torre de Hanoi, y las variables relacionadas con el deseo sexual fueron valoradas mediante el Test del Deseo Sexual Inhibido, el Inventario del Deseo Sexual (SDI-2, sigla de Sexual Desire Inventory) y la Escala de la Actitud hacia las Fantasías Sexuales. Resultados: Se encontraron correlaciones entre las variables del deseo sexual, disposición hacia las fantasías sexuales y el deseo sexual inhibido; deseo sexual total y diádico y disposición hacia las fantasías sexuales correlacionó con el control inhibitorio; y el deseo sexual inhibido correlacionó con la planificación y el control de impulsos. Discusión: Los hallazgos del estudio llaman la atención sobre las implicaciones educativas encaminadas a desarrollar las funciones ejecutivas en adolescentes y jóvenes con el fin prevenir conductas sexuales de riesgo.to formulate new hypotheses in the field of sexuality and neurosciences. The study findings draw attention to the educational implications aimed to develop the executive functions in adolescents and young people to prevent risky sexual behavior.
Forecasting saltwater intrusion volume and sulfate content in a wastewater collection system. Case study: Barreiro/Moita WWTP, Portugal
Authors: Figueiredo A. , Amaral L. , Pacheco J. 
Published: October 2021

Abstract
The presence of salt water from the Tagus Estuary has been identified in the influent at Barreiro/Moita Wastewater Treatment Plant (WWTP), Portugal. The intrusion occurs throughout damaged sections and direct vectors in the wastewater collection system, during high tide levels, changing the wastewater characteristics and impacting the WWTP process. This study designed models to quantify this problem, enabling more effective countermeasures within the right timing. The proposed models estimate the average volume of salt water and sulfate () load for each high tide period. The laboratory results show strong correlations between the influent electrical conductivity (EC) and percentage of salt water in WWTP inflow (0.9909), and between EC and concentration in WWTP influent (0.9797). The forecast models also show good correlation between the high tide levels with volume of salt water (0.9145) and load (0.9162) entering the system. Considering the total monthly inflow, the highest percentage of salt water registered in WWTP inflow was 3.6%. During high tide periods, critical situations have been assessed with up to 53.9% of salt water in the WWTP inflow, increasing energy consumption and costs in pumping stations.
Real-time 3D Object Detection Using Improved Convolutional Neural Network Based on Image-driven Point Cloud
Authors: Gao Zhiyong , Xiang Jianhong 
Published: October 2021

Background:
While detecting the object directly from the 3D point cloud, the natural 3D
patterns and invariance of 3D data are often obscure.

Objective:
In this work, we aimed at studying the 3D object detection from discrete, disordered and
sparse 3D point clouds.

Methods:
The CNN comprises the frustum sequence module, 3D instance segmentation module SNET,
3D point cloud transformation module T-NET, and 3D boundary box estimation module ENET.
The search space of the object is determined by the frustum sequence module. The instance
segmentation of the point cloud is performed by the 3D instance segmentation module. The 3D coordinates
of the object are confirmed by the transformation module and the 3D bounding box estimation
module.

Results:
Evaluated on KITTI benchmark dataset, our method outperforms state of the art by remarkable
margins while having real-time capability.

Conclusion:
We achieve real-time 3D object detection by proposing an improved Convolutional
Neural Network (CNN) based on image-driven point clouds.
Small Targets Detection for Transmission Tower Based on SRGAN and Faster RCNN
Authors: Liu Runze , Yan Guangwei , He Hui , An Yubin , Wang Ting , Huang Xile 
Published: October 2021

Background:
Power line inspection is essential to ensure the safe and stable operation of
the power system. Object detection for tower equipment can significantly improve inspection efficiency.
However, due to the low resolution of small targets and limited features, the detection accuracy
of small targets is not easy to improve.

Objective:
This study aimed to improve the tiny targets’ resolution while making the small target's
texture and detailed features more prominent to be perceived by the detection model.

Methods:
In this paper, we propose an algorithm that employs generative adversarial networks to
improve small objects' detection accuracy. First, the original image is converted into a superresolution
one by a super-resolution reconstruction network (SRGAN). Then the object detection
framework Faster RCNN is utilized to detect objects on the super-resolution images.

Results:
The experimental results on two small object recognition datasets show that the model proposed
in this paper has good robustness. It can especially detect the targets missed by Faster RCNN,
which indicates that SRGAN can effectively enhance the detailed information of small targets by
improving the resolution.

Conclusion:
We found that higher resolution data is conducive to obtaining more detailed information
of small targets, which can help the detection algorithm achieve higher accuracy. The small object detection
model based on the generative adversarial network proposed in this paper is feasible and more
efficient. Compared with Faster RCNN, this model has better performance on small object detection.
Analytical Procedure for determination and statistical validation of novel drug Mafenide acetate in pharmaceutical formulations
Authors: S.F.Choragudi  , NavyaYanamandra K.S  , Chandrika kethineni  , Sharmila Thokala  
Published: October 2021

Requirement for a sophisticated analytical method using HPLC and HPTLC is in high demand to meet the needs of a small scale industry for analysis of drugs that are relatively expensive. Hence a simple method was proposed in the routine determination of Mafenide acetate in pharmaceutical formulations and bulk dosage forms that can be less expensive. An analytical method was developed for the estimation of Mafenide acetate drug substance by liquid chromatography. The chromatographic separation was achieved on phenyl column (Eclipse XDB-Phenyl 250*4.6, 5um) at ambient temperature. The separation was achieved employing a mobile phase consisting of 0.1 %v/v Trifluoroacetic acid in water: Methanol (10:90). The flow rate was 1.0 ml/ minute and ultraviolet detector at 245nm. The average retention time for Mafenide acetate was 3.3 minutes. The proposed method was validated for selectivity, precision, linearity and accuracy. All validation parameters were checked and are found within the acceptable range. The assay methods were found to be linear ranging from 50-150 µg/ml for Mafenide acetate. The parameters considered for the procedure are related limit, selectivity, linearity, range, accuracy and precision are defined. Thesample solution leads to unequivocal, absolute identification of the analyte peak of interest apart from all other matrix components. The objective of our work is to form a basis for production procedure and control, which are designed to assure that the drug products have the identity, Quality, and purity. The results obtained could be treated as simple, sensitive and reproducible for determination of Mafenide acetate in pharmaceutical formulations.
Pengaruh Model Pembelajaran Kooperatif Tipe Student Teams Achievement Division terhadap Hasil Belajar Menggiring Bola Dalam Permainan Sepakbola
Authors: . I KADEK KUSUMA MANDALA PUTRA , . I Putu Darmayasa, S.Pd., M.For. , . Ni Putu Dwi Sucita Dartini, S.Pd., M.Pd. 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran kooperatif tipe STAD terhadap hasil belajar menggiring bola dalam permainan sepakbola. Jenis penelitian ini adalah ekperimen sungguhan (true experimental) dengan dengan menggunakan rancangan penelitiaan the randomized posttest only control group the same subjec design. Populasi dari penelitian ini adalah kelas XI SMK Pariwisata Triatma Jaya Singaraja tahun pelajaran 2019/2020. Sampel dipilih menggunakan teknik random sampling. Instrumen penelitian yang digunakan berupa lembar unjuk kerja. Teknik analisis data yang digunakan adalah uji independent samples t-test berbantuan IBM SPSS Statistics 23. Analisis data rata-rata nilai kelompok eksperimen adalah 89,53 sedangkan kelompok kontrol 83,90 (89,53 > 83,90). Berdasarkan hasil analisis diperoleh nilai signifikansi sebesar 0,00 < 0,05 sehingga diterima. Disimpulkan model pembelajaran kooperatif tipe Student Teams Achievement Division berpengaruh signifikan terhadap hasil belajar menggiring bola dalam permainan sepakbola (menggiring bola menggunakan kaki bagian dalam dan kaki bagian luar) pada siswa kelas XI SMK Pariwisata Triatma Jaya Singaraja tahun pelajaran 2019/2020. Dengan demikian disarankan kepada guru PJOK dapat menerapkan model pembelajaran kooperatif tipe Student Teams Achievement Division karena terbukti bepegaruh singnifikan terhadap hasil belajar siswa.

Kata Kunci : Kata kunci: Hasil Belajar, Sepakbola, STAD This study aimed to know the effect of cooperative learning model type STAD toward the students’ learning outcomes of dribbling technique in football. This study was true experimental research which used randomized posttest only control group the same subject design. The population of this study was grade XI of SMK Pariwisata Triatma Jaya Singaraja in academic year 2019/2020. The sample was chosen by random sampling technique. The instrument used was in the form of activity sheets. The data analysis technique used was independent samples t-test assisted by IBM SPSS Statistics 23. The average value of experimental group was 89.53, meanwhile the control group was 83.90 (89.53 > 83.90). Based on analysis result, it was obtained significant value of 0.00 < 0.05, which means the Hawas acceptable. In conclusion, the cooperative learning model type Student Team Achievement Division has significant effect toward the students’ learning outcomes of dribbling technique in football (dribbling with inside legs and outside legs) in XI grade students of SMK PariwisataTriatma Jaya Singaraja in Academic Year 2019/2020. Recommenaet to physical education teachar is suggested to apply this cooperative learning model (Student Teams Achievement Division) because it was proven in giving the significant effect toward the students’ learning result.
Keywords: Learning outcome, football, STAD
keyword : Keywords: Learning outcome, football, STAD
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STUDENT TEAMS ACHIEVEMENT DIVISION TERHADAP HASIL BELAJAR PASSING SEPAKBOLA
Authors: Tama I Gede Surya , Artanayasa I Wayan , Satyawan I Made 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran STAD terhadap hasil belajar teknik dasar passing (kaki bagian dalam dan kaki bagian luar) sepakbola. Jenis penelitian adalah eksperimen sungguhan (true experimental) dengan rancangan the randomized pretest-posttest control group the same subjec design. Populasi penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 7 Singaraja tahun pelajaran 2018/2019, keseluruhan kelas berjumlah 5 kelas dengan populasi 158 orang. Pengambilan sampel yang digunakan simple random sampling berdasarkan kelas. Kelas yang menjadi sampel penelitian adalah kelas VIIIA sebagai kelompok eksperimen dan VIIIB sebagai kelompok kontrol. Eksperimen dilakukan sebanyak 2 kali perlakuan diluar pretes-posttest. Data hasil belajar dikumpulkan melalui tes objektif, observasi dan unjuk kerja. Analisis data menggunakan uji-t dengan bantuan SPSS 16.0 for Windows. Rata-rata kelompok eksperimen adalah 0.61 lebih tinggi dari rata-rata kelompok kontrol adalah 0.50. Signifikansi pada uji hipotesis diperoleh melalui uji parametrik (uji Independent Samples Test) adalah 0.001 yaitu p<0,05. Disimpulkan bahwa model pembelajaran STAD berpengaruh signifikan terhadap hasil belajar teknik dasar passing (kaki bagian dalam dan kaki bagian luar) sepakbola. Disarankan kepada guru penjasorkes dapat menerapkan model pembelajaran STAD karena terbukti berpengaruh signifikan terhadap hasil belajar siswa.
EFEK PELATIHAN WASIT MELALUI VIRTUAL MEETING TERHADAP PENINGKATAN KOMPETENSI SDM WASIT SENAM TINGKAT PROVINSI TAHUN 2020
Authors: Febrianty Mona Fiametta , Sutresna Nina , Hidayah Nida'ul 
Published: October 2021

Peran seorang wasit pada cabang olahraga tidak terukur dalam hal ini adalah Senam memiliki posisi yang amat sentral. Kualifikasi wasit senam turut mempengaruhi keberhasilan atlet dalam meraih prestasi. Sehingga penyebaran SDM wasit yang berkualitas sangatlah diharapkan tersebar secara merata. Untuk mewujudkan pemerataan SDM perlu dilakukan pelatihan terhadap para wasit yang merupakan perwakilan dari tiap kota atau kabupaten. Pada masa pandemik Covid-19 ini tidaklah memungkinkan untuk melakukan pelatihan secara tatap muka langsung, oleh sebab itu alternative yang dapat dilakukan adalah dengan virtual meeting. Tujuan penelitian ini adalah untuk mengetahui efek dari pelatihan secara virtual terhadap peningkatan kompetensi wasit senam. Metode penelitian yang digunakan yaitu pre eksperimental design. Populasi penelitian ini adalah wasit senam tingkat provinsi dengan sample sebanyak 30 orang. Instrumen yang digunakan adalah butir soal mengenai perwasitan berjumlah 40 soal. Hasil penelitian ini menunjukkan bahwa terdapat peningkatan kompetensi SDM wasit yang signifikan melalui pelatihan wasit secara virtual meeting.
Educación superior: factores económicos que inciden en la deserción escolar. Caso de las licenciaturas de la UNID Tlalnepantla
Authors: De Oca Sánchez Teresa Montes 
Published: October 2021

El objetivo del presente trabajo fue determinar los aspectos económicos que influyen en el abandono escolar de los estudiantes de la Universidad Interamericana para el Desarrollo (UNID), campus Tlalnepantla. Para ello, se empleó el método cualitativo de análisis transversal. Los estudiantes elegidos fueron los 28 que presentaron baja para el cuatrimestre enero-abril de 2020, aunque la entrevista aplicada solo fue contestada por 17 de ellos. En definitiva, las siguientes fueron las razones por las cuales tuvieron que abandonar: necesidad de trabajar (7), pérdida de porcentaje de beca (4), situación académica (3), rezago en pagos y generación de intereses (2) y enfermedad (1). Por ello, se tomó la decisión de generar una reunión informativa para el área de promoción en donde se les capacite en torno a los programas ofertados y sus alcances. Además, se está estudiando la posibilidad de incrementar las estrategias de apoyo económico para los alumnos, fundamentalmente por medio de programas de financiamiento prorrogado para la conclusión de los estudios, ya que hasta el momento la prórroga vence con el cierre cuatrimestral. Asimismo, con asesorías se atenderá a aquellos estudiantes en riesgo de rezago para disminuir sus posibilidades de abandono.
On relations in science: the case of the scientific journal editorial board
Authors: Bolshakov D. Yu. 
Published: October 2021

This article analyses the connections between members of the editorial board of a scientific journal which are formed based on their reviews of scientific articles. It is shown that the connections can be represented as a graph. The research uses the data for six years of article reviewing in the scientific and technical Journal of "Almaz — Antey" Air and Space Defence Corporation.The methods of analysis are combinatorics and graph theory, as well as the relevant graph characteristics: adjacency matrix, incidence matrix, reachability matrix, graph fullness and connectivity, nearest neighbours graph and graph spanning tree.It is shown that cooperation of the reviewers of the Journal helps plot a connected graph with links between any two vertices, i.e. between any reviewers.The graph is analysed and the methods of its application to calculate the Journal’s scientometric indicators are demonstrated. As the research reveals, a journal that publishes articles in numerous disciplines forms connections between all reviewers and this parameter can be indicative of interchangeability within the scientific fields or, conversely, of a joint work in this scientific field when reviewing manuscripts. Based on the research results, it is possible to search for new reviewers in the areas where competencies are underdeveloped. And by the areas where competencies are strong, we can determine the core competence of the reviewers of a scientific journal, reflecting the main focus of the evaluated scientific research.The work resulted in the formulated scientometric indicators of the journal, which can be used to search for and involve new reviewers or to represent data on a strong team of reviewers on a specific topic, as well as on a new scientific field just emerging for research.
Reseña del servicio de radio de banda ancha ciudadana
Authors: Corral-De-Witt Danilo , Bermeo Guerrero Yessenia , Cachimuel Juan Carlos , Rojo-Álvarez José Luis , Tepe Kemal 
Published: October 2021

El presente artículo ofrece una reseña del Servicio de Radio de Banda Ancha Ciudadana (CBRS) y sus características. También describe el Sistema de acceso al espectro el cual permite que las bandas no utilizadas por los usuarios primarios sean ocupadas de forma inteligente por usuarios secundarios para optimizar el uso de este recurso. Como regla general, CBRS opera entre 3550 MHz y 3700 MHz para permitir la conectividad de los usuarios desde diferentes operadores en ubicaciones de alto tráfico mediante el uso de host neutrales, con el fin de minimizar los costos de instalación y operación a los operadores del Servicio Móvil Avanzado. CBRS también funciona como una red LTE privada, la cual cuenta con varias ventajas con respecto a otras tecnologías de redes inalámbricas. Esta innovadora propuesta marca un hito en el cambio de la asignación fija del espectro de radio a un acceso dinámico controlado, lo que permite la conectividad a una amplia gama de dispositivos inalámbricos.