bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression
Authors: Chen Yujing , Meng Peilin , Cheng Shiqiang , Jia Yumeng , Wen Yan , Yang Xuena , Yao Yao , Pan Chuyu , Li Chun’e , Zhang Huijie , Zhang Jingxi , Zhang Zhen , Zhang Feng 
Published: September 2021

AbstractCumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, the role of interaction between gut dysbiosis and C-reactive protein (CRP) in the development of anxiety and depression remains to be elucidated. In this study, a total of 3321 independent single nucleotide polymorphism (SNP) loci associated with gut microbiome were driven from genome-wide association study (GWAS). Using individual level genotype data from UK Biobank, we then calculated the polygenetic risk scoring (PRS) of 114 gut microbiome related traits. Moreover, regression analysis was conducted to evaluate the possible effect of interaction between gut microbiome and CRP on the risks of Patient Health Questionnaire-9 (PHQ-9) (N = 113,693) and Generalized Anxiety Disorder-7 (GAD-7) (N = 114,219). At last, 11 candidate CRP × gut microbiome interaction with suggestive significance was detected for PHQ-9 score, such as F_Ruminococcaceae (β = − 0.009, P = 2.2 × 10–3), G_Akkermansia (β = − 0.008, P = 7.60 × 10–3), F_Acidaminococcaceae (β = 0.008, P = 1.22 × 10–2), G_Holdemanella (β = − 0.007, P = 1.39 × 10–2) and O_Lactobacillales (β = 0.006, P = 1.79× 10–2). 16 candidate CRP × gut microbiome interaction with suggestive significance was detected for GAD-7 score, such as O_Bacteroidales (β = 0.010, P = 4.00×  10–4), O_Selenomonadales (β = − 0.010, P = 1.20 × 10–3), O_Clostridiales (β = 0.009, P = 2.70 × 10–3) and G_Holdemanella (β = − 0.008, P = 4.20 × 10–3). Our results support the significant effect of interaction between CRP and gut microbiome on the risks of anxiety and depression, and identified several candidate gut microbiomes for them.
Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway
Authors: Qi Feng , Qin Wenxing , Zhang Yao , Luo Yongde , Niu Bing , An Quanlin , Yang Biwei , Shi Keqing , Yu Zhijie , Chen Junwei , Cao Xin , Xia Jinglin 
Published: September 2021

Abstract
Background
Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate and drug resistance.

Methods
Suppression of TRCs may thus be an effective therapeutic strategy for treating this fatal disease. We evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of HCC TRCs, and assessed its preclinical efficacy in models of HCC patient-derived xenografts (PDXs).

Results
Sulfarotene selectively inhibited the growth of HCC TRCs in vitro and significantly deterred TRC-mediated tumor formation and lung metastasis in vivo without apparent toxicity, with an IC50 superior to that of acyclic retinoid and sorafenib, to which the recurrent HCC exhibits significant resistance at advanced stage. Sulfarotene promoted the expression and activation of RARα, which down-regulated SOS2, a key signal mediator associated with RAS activation and signal transduction involved in multiple downstream pathways. Moreover, sulfarotene selectively inhibited tumorigenesis of HCC PDXs with high expression for SOS2.

Conclusions
Our study identified sulfarotene as a selective inhibitor for the TRCs of HCC, which targets a novel RARα-SOS2-RAS signal nexus, shedding light on a new, promising strategy of target therapy for advanced liver cancer.
CPR with restricted patient access using alternative rescuer positions: a randomised cross-over manikin study simulating the CPR scenario after avalanche burial
Authors: Wallner Bernd , Moroder Luca , Salchner Hannah , Mair Peter , Wallner Stefanie , Putzer Gabriel , Strapazzon Giacomo , Falk Markus , Brugger Hermann 
Published: September 2021

Abstract
Background
The aim of this manikin study was to evaluate the quality of cardiopulmonary resuscitation (CPR) with restricted patient access during simulated avalanche rescue using over-the-head and straddle position as compared to standard position.

Methods
In this prospective, randomised cross-over study, 25 medical students (64% male, mean age 24) performed single-rescuer CPR with restricted patient access in over-the-head and straddle position using mouth-to-mouth ventilation or pocket mask ventilation. Chest compression depth, rate, hand position, recoil, compression/decompression ratio, hands-off times, tidal volume of ventilation and gastric insufflation were compared to CPR with unrestricted patient access in standard position.

Results
Only 28% of all tidal volumes conformed to the guidelines (400–800 ml), 59% were below 400 ml and 13% were above 800 ml. There was no significant difference in ventilation parameters when comparing standard to atypical rescuer positions. Participants performed sufficient chest compressions depth in 98.1%, a minimum rate in 94.7%, correct compression recoil in 43.8% and correct hand position in 97.3% with no difference between standard and atypical rescuer positions. In 36.9% hands-off times were longer than 9 s.

Conclusions
Efficacy of CPR from an atypical rescuer position with restricted patient access is comparable to CPR in standard rescuer position. Our data suggest to start basic life-support before complete extrication in order to reduce the duration of untreated cardiac arrest in avalanche rescue. Ventilation quality provided by lay rescuers may be a limiting factor in resuscitation situations where rescue ventilation is considered essential.
High incidence and mortality of Pneumocystis jirovecii infection in anti-MDA5-antibody-positive dermatomyositis: experience from a single center
Authors: Huang Linlin , Fu Qiong , Ye Yan , Lin Yanwei , Yan Qingran , Chen Sheng 
Published: September 2021

Abstract
Background
Idiopathic inflammatory myopathies (IIM) are associated with a significantly higher risk of opportunistic infections including Pneumocystis jirovecii pneumonia (PJP), a potentially fatal opportunistic infection. However, no prior studies have evaluated PJP infection in subtypes of IIM.

Objectives
To investigate the prevalence and mortality rate of PJP infection in subgroups of IIM patients stratified according to myopathy-specific antibodies.

Methods
In the first part of the study, 463 consecutive patients with IIM were prospectively followed for a period of at least 1 year to analyze the incidence of PJP. In the second part of the study, we enrolled 30 consecutive PJP patients with any rheumatic disease in order to identify the mortality rate and risk factors by Cox regression analysis. The Kaplan-Meier method with log-rank testing was used to assess differences in survival.

Results
The prevalence of PJP in IIM patients was found to be 3.0/100 person-years, while in MDA5+ DM patients it was 7.5/100 person-years and in MDA5− IIM patients 0.7/100 person-years (P < 0.05). PJP typically occurred in the first 2 months in the case of MDA5+ DM patients who had a significant decrease in their CD4+ T cell counts and lymphocyte counts (P < 0.05). In PJP patients, 3-month mortality was higher for MDA5+ DM patients than in those with other rheumatic diseases (83.3% vs 38.9%, P < 0.05). Alarmingly, MDA5+ DM patients seemed not to benefit from prompt anti-PJP treatment, unlike patients with other rheumatic diseases whose survival improved when anti-PJP treatment was started within 6 days (P < 0.05).

Conclusion
PJP has an alarming high incidence and mortality in MDA5+ DM patients. Timely treatment for PJP seems not to improve the prognosis of patients with this particular subtype. Hence, there remains a crucial unmet need to develop PJP prophylaxis for MDA5+ DM patients.
Secukinumab in non-radiographic axial spondyloarthritis: subgroup analysis based on key baseline characteristics from a randomized phase III study, PREVENT
Authors: Braun Jürgen , Blanco Ricardo , Marzo-Ortega Helena , Gensler Lianne S. , van den Bosch Filip , Hall Stephen , Kameda Hideto , Poddubnyy Denis , van de Sande Marleen , Wiksten Anna S. , Porter Brian O. , Shete Abhijit , Richards Hanno B. , Haemmerle Sibylle , Deodhar Atul 
Published: September 2021

Abstract
Background
To investigate the efficacy of secukinumab in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) grouped by disease activity as assessed by C-reactive protein (CRP) levels and/or magnetic resonance imaging (MRI) scores, human leukocyte antigen (HLA)-B27 status, and sex.

Methods
The phase III PREVENT study randomized (1:1:1) 555 patients to receive subcutaneous secukinumab 150 mg with (LD) or without (NL) loading dose or placebo weekly, followed by every 4 weeks starting at week 4. Here, we report the results of a post hoc analysis reporting the efficacy outcomes (pooled secukinumab) to 16 weeks by CRP, MRI, HLA-B27, and sex.

Results
Efficacy differences between the secukinumab and the placebo groups were highest in the CRP+, MRI+, HLA-B27+, and male subgroups, particularly for Ankylosing Spondylitis Disease Activity Score-CRP inactive disease and Assessment of SpondyloArthritis international Society (ASAS) partial remission outcomes. ASAS40 response rates in the CRP+/MRI+ subgroup was 52.3% (secukinumab) versus 21.8% (placebo; P < 0.0001) at week 16. ASAS40 response rates (secukinumab versus placebo) were 43.9% versus 32.6% in HLA-B27+, 32.7% versus 16.4% in HLA-B27− subgroups, 51.2% versus 30.8% in male, and 31.7% versus 25.3% in female patients, respectively.

Conclusions
Secukinumab improved the signs and symptoms of nr-axSpA across patients grouped by CRP (+/−) and/or MRI (+/−) status, HLA-B27 (+/−) status, and sex. The highest treatment differences between secukinumab and placebo were observed in patients with both elevated CRP and evidence of sacroiliitis on MRI. Treatment difference was minimal between HLA-B27 (+) and (−) subgroups. Male patients had higher relative responses than female patients.

Trial registration
ClinicalTrials.gov, NCT02696031. Registered on 02 March 2016
Effect of the uncoupling protein-2 (UCP-2) and nuclear receptor subfamily 3 group C member 1 (NR3C1) genes on treatment efficacy and survival in patients with multiple myeloma: a single-center study
Authors: Demir Ilknur , Pehlivan Sacide , Okan Vahap , Sahin Handan Haydaroglu , Durusoy Salih Sertaç , Serin Istemi , Oyaci Yasemin , Pehlivan Mustafa 
Published: September 2021

Abstract
Objective
Studies on the genetic background of patients with multiple myeloma (MM) have been increasing; two important factors considered in such works are uncoupling protein-2 (UCP-2) and nuclear receptor subfamily 3 group C member 1 (NR3C1). We aim to reveal the association of MM with NR3C1 and UCP-2 gene polymorphisms. In this prospective study, 200 patients diagnosed between January 2009 and 2018 and 200 healthy individuals were included. For patients who had undergone autologous stem cell transplantation and control subjects, we statistically compared the CC, GC, and GG genotypes and the C and G alleles of the NR3C1 gene, as well as the AA, AG, and GG genotypes and the A and G alleles of the UCP-2 gene.

Results
While the AA genotype was significantly more common in the MM group (p = 0.001), the GG genotype was significantly more common in the control group (p = 0.016). Overall survival was found to be significantly shorter in patients with the UCP-2 GG genotype (p = 0.034). It was also found that having the GG genotype of the UCP-2 gene was a 2.48-fold risk factor for mortality. The fact that overall survival is significantly shorter in MM patients with the UCP-2 GG genotype and its definition as a risk factor for mortality have been put forward for the first time in the literature.
Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias
Authors: Arpke Robert W. , Shams Ahmed S. , Collins Brittany C. , Larson Alexie A. , Lu Nguyen , Lowe Dawn A. , Kyba Michael 
Published: September 2021

Abstract
Background
Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have investigated hindlimb locomotory muscles, principally the tibialis anterior, in caged sedentary mice, where those muscles are abnormally under-exercised.

Methods
We analyze satellite cell numbers in 8 muscle groups representing locomotory and non-locomotory muscles in young and 2-year-old mice and perform transplantation assays of low numbers of hind limb satellite cells from young and old mice.

Results
We find that satellite cell density does not decline significantly by 2 years of age in most muscles, and one muscle, the masseter, shows a modest but statistically significant increase in satellite cell density with age. The tibialis anterior and extensor digitorum longus were clear exceptions, showing significant declines. We quantify self-renewal using a transplantation assay. Dose dilution revealed significant non-linearity in self-renewal above a very low threshold, suggestive of competition between satellite cells for space within the pool. Assaying within the linear range, i.e., transplanting fewer than 1000 cells, revealed no evidence of decline in cell-autonomous self-renewal or regenerative potential of 2-year-old murine satellite cells.

Conclusion
These data demonstrate the value of comparative muscle analysis as opposed to overreliance on locomotory muscles, which are not used physiologically in aging sedentary mice, and suggest that self-renewal impairment with age is precipitously acquired at the geriatric stage, rather than being gradual over time, as previously thought.
Greedy maximin distance sampling based model order reduction of prestressed and parametrized abdominal aortic aneurysms
Authors: Schein Alexander , Gee Michael W. 
Published: September 2021

AbstractThis work proposes a framework for projection-based model order reduction (MOR) of computational models aiming at a mechanical analysis of abdominal aortic aneurysms (AAAs). The underlying full-order model (FOM) is patient-specific, stationary and nonlinear. The quantities of interest are the von Mises stress and the von Mises strain field in the AAA wall, which result from loading the structure to the level of diastolic blood pressure at a fixed, imaged geometry (prestressing stage) and subsequent loading to the level of systolic blood pressure with associated deformation of the structure (deformation stage). Prestressing is performed with themodified updated Lagrangian formulation(MULF) approach. The proposed framework aims at a reduction of the computational cost in a many-query context resulting from model uncertainties in two material and one geometric parameter. We apply projection-based MOR to the MULF prestressing stage, which has not been presented to date. Additionally, we propose a reduced-order basis construction technique combining the concept of subspace angles and greedy maximin distance sampling. To further achieve computational speedup, the reduced-order model (ROM) is equipped with theenergy-conserving mesh sampling and weightinghyper reduction method. Accuracy of the ROM is numerically tested in terms of the quantities of interest within given bounds of the parameter domain and performance of the proposed ROM in the many-query context is demonstrated by comparing ROM and FOM statistics built from Monte Carlo sampling for three different patient-specific AAAs.
Parental mental illness and their offspring’s mental health in Rwanda: neuropsychiatric hospital of Rwanda
Authors: Rusengamihigo Donat , Mutabaruka Jean , Biracyaza Emmanuel , Magalakaki Olga , El’Husseini Mayssa 
Published: September 2021

AbstractBackgroundOffspring of the parents with mental disorders are at higher risk to have the mental diseases throughout the world. This study examined the association between psychopathology of parents and the mental health of their offspring in Neuropsychiatric Hospital of Rwanda, Butare Branch.MethodsA cross-sectional study made up of case and control offspring was conducted on the case group made up of 80 offspring born to parents with mental diseases and a control group of 80 offspring from parents without mental disease. Hamilton Rating Scale for Depression (HRSD, α = 0.82), Posttraumatic stress disorders scale (PTSD, α = 0.73) and the Test of Psychological Problems (TPP, α = 0.93) were used. STATISTICA version 8 was used for statistical analysis.ResultsResults indicated a significance difference between the two groups on depressive symptoms, psychological problems and PTSD symptomatology. The case group seemed to experience high level symptoms than the control group. Results indicated that, among the offspring born to parents with mental disease, there was a significant correlation between anxiety and depression symptoms (r = 0.71,p < .001), PTSD and eating disorder (r = 0.75,p < .001), domestic violence and PTSD (r = 0.78,p < .001), aggressive behavior and PTSD (r = 0.79,p < .001), somatoform disorders and PTSD (r = 0.98,p < .001). No significant association between the low self-esteem, depression, anxiety, mental disorders induced drug abuse and PTSD was found.ConclusionOffspring of the parents with mental disorders had higher risk to develop mental diseases than the offspring born to the parents without mental diseases. Taking into account the assessment of parents’ mental illness when taking care of the offspring’s psychological disorders is needed in the neuropsychiatric hospital.
Global fashion retailers’ responses to external and internal crises during the COVID-19 pandemic
Authors: Kim Sanghee , Woo Hongjoo 
Published: September 2021

AbstractDuring the COVID-19 pandemic crisis, the media reported different kinds of issues that global fashion retailers face. They had to unexpectedly dismiss garment workers and employees internally, while they had to perform CSR practices for their suffering communities externally. The purpose of this study is to investigate how global fashion retailers responded to these external and internal crises during the pandemic through a case study. Based on corporate social responsibility (CSR) contribution types and the Situational Crisis Communication Theory (SCCT), various secondary sources which are related to three selected global fashion retailers’ (Zara, H&M, and Uniqlo) responses to external and internal crises during the pandemic are analyzed. The findings indicate that global fashion retailers showed some different approaches in their responses to external and internal crises during the pandemic. Externally, all of them practiced CSR by providing monetary and in-kind contributions to the society. However, toward the internal issues related to their factory workers and employees, some of them denied or diminished the problems that had been raised, while all of them attempted to make a deal with the parties who had been affected. The results of this study propose an agenda to discuss global fashion retailers’ responsibilities during the pandemic, as well as to inform fashion retailers of how leading retailers have responded to the crises.
Stability analysis for two-layered slopes by using the strength reduction method
Authors: Sarkar Sourav , Chakraborty Manash 
Published: September 2021

AbstractThe aim of this article is to present the slope stability charts for two layered soil slopes by using the strength reduction method (SRM). The primary focus is to provide a quantitative estimation of the improvement of slope stability when a stronger layer is placed over the weaker layer. The SRM carried in this work comprises a series of finite element lower bound (LB) and upper bound (UB) limit analysis in conjunction with nonlinear optimization. Unlike the limit equilibrium method (LEM), there is no need to consider any prior assumptions regarding the failure surface in SRM. The study is carried out for different combinations of (i) slope angles (β), (ii) strength properties of the top and the bottom layer (c, ϕ) and (iii) different thickness of the top layer. The failure patterns are shown for a few cases.
Numerical and experimental modeling of geomechanical behavior of partially saturated soils
Authors: Sadeghabadi Alireza , Noorzad Ali , Zad Amirali 
Published: September 2021

AbstractThe Barcelona Basic Model (BBM) has been implemented in a finite difference-based computer program to simulate the behavior of unsaturated soils subjected to wetting. The BBM implementation was verified using analytical solutions, and the proposed model has been used to simulate the response of a compacted embankment under complete saturation and suction induced conditions. Numerical analyses indicate that considerable amount of total and differential settlements could develop at the top surface of the embankment. BBM is executed into FLAC2D extending a defined module for modified Cam Clay (MCC) and has been set up an analytical solution for suction-dependent stress and strain. Evaluating the effect of anisotropy and nonlinear apparent tensile strength in unsaturated soils, a modification to BBM formulation has been proposed and optimized by developing numerical analyses to reduce the size of elastic region of loading collapse (LC) curve. Then, an experimental study in the literature is investigated by utilizing comparative curves from BBM and modified BBM indicating well agreement with natural circumstances. As a result of the work presented in this research, finite difference codes with BBM and modified BBM has the capability of simulating the real behavior and is operational being applied to problems associated with earthen structures in unsaturated or partially saturated of expansive soils as a three-phases medium.
Clinical progression of patients with COVID-19 in Lagos State, Nigeria
Authors: Mbagwu JP. C. , Olajugba J. O. , James-Okoro Paula-Peace , Blessing Obidike 
Published: September 2021

Abstract
Background
The majority of COVID-19 research has been devoted to characterizing the epidemiology and early clinical aspects of the virus. In Lagos, Nigeria, we looked at the temporal progression of COVID-19 patients. We included 1337 confirmed COVID-19 cases in our study from February 27th to March 27th 2020. Of the 1337 patients enrolled, the median age was 50 years old, and 800 (59.83%) were male while 537 (40.16%) were female.

Method
In symptomatic patients, the time from the beginning of signs to admission was 4 (2–7) days. Fever occurred in 217 (16.2%) while cough occurred in 211(15.78%) patients respectively. Patients were given 5–6 treatment, including nutrition support, supplementary oxygen, and antiviral medicines (e.g., Remdesivir, dexamethasone) in a limited percentage of cases. The assessed median period of infection in all patients was 10 days after the start of symptoms (95 confidential intervals [CIs]: 8–11 days). The duration of fever was slightly longer in patients admitted to intensive care units (ICU) than in those who were not (31 days versus 9 days, respectively, P < 0.003).

Results
On day 7 after the onset of symptoms, radiological deterioration of the original picture was found in 500 (37.39%) patients. On day 13, 154 of these patients (94.5%) showed signs of radiological improvement. The average time it took for upper respiratory tract samples to test negative for reverse transcriptase PCR was 10 days (90 percent confidence interval: 10–12 days). Virus clearance was more significant in ICU patients than in non-ICU patients (P < 0.003).

Conclusions
Community members should continue to adhere to the recommended methods of preventing the spread of COVID-19 infection and patients should seek care early to reduce the risk of mortality associated with the infection as rapidly as possible.