bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose reduction of the new generation biologics (IL-17 and IL-23 inhibitors) in psoriasis: study protocol for an international, pragmatic, multicenter, randomized, controlled, non-inferiority study—the BeNeBio study
Authors: van der Schoot Lara S. , van den Reek Juul M. P. A. , Grine Lynda , Schots Lisa , Kievit Wietske , Lambert Jo L. W. , de Jong Elke M. G. J. 
Published: October 2021

Abstract
Background
Psoriasis is a chronic immune-mediated inflammatory skin disease for which biologics are effective treatments. Dose reduction (DR) of the first generation biologics seems a promising way for more efficient use of expensive biologics. A substantial part of patients on tumor necrosis factor (TNF)-alfa inhibitors and ustekinumab could successfully lower their dose, after following a tightly controlled DR strategy. The objective of this study is to assess whether controlled DR of interleukin (IL)-17 and IL-23 inhibitors in psoriasis patients with low disease activity is non-inferior (NI) to usual care (UC).

Methods
This is an international, prospective, multicenter, pragmatic, randomized, non-inferiority trial. A total of 244 patients with stable low disease activity (Psoriasis Area and Severity Index (PASI) ≤ 5) for at least 6 months and using secukinumab, ixekizumab, brodalumab, guselkumab, risankizumab, or tildrakizumab in the standard dose, together with stable low disease activity, defined as a PASI ≤ 5 and Dermatology Life Quality Index (DLQI) ≤ 5 at the moment of inclusion, will be randomized 2:1 to DR or UC. In the DR group, dosing intervals will be prolonged stepwise to achieve 66% and 50% of the original dose. Disease activity is monitored every 3 months by PASI and DLQI. In case of disease flare (i.e., PASI and/or DLQI increase), treatment is adjusted to the previous effective dose. The primary outcome is the incidence proportion of persistent flares (PASI > 5 for ≥ 3 months), which will be compared between arms. Secondary outcomes include proportion of patients with successful DR, (course of) PASI and DLQI, serious adverse events (SAEs), health-related quality of life, costs, and pharmacokinetic profile. Outcomes of DR will be compared to UC.

Discussion
With this study, we aim to assess whether DR of IL-17 and IL-23 inhibiting biologics can be achieved for psoriasis patients with low disease activity, without losing disease control. Reducing the dose may lead to more efficient use of biologics.

Trial registration
ClinicalTrials.govNCT04340076. Registered on April 9 2020.
The effect of microwave stabilization on the properties of whole wheat flour and its further interpretation by molecular docking
Authors: Qu Chenling , Yang Qiankui , Ding Lina , Wang Xueke , Liu Shengqiang , Wei Min 
Published: October 2021

AbstractIn order to stabilize the whole wheat flour and extend its shelf life, microwave was employed to heat the wheat bran to inactivate the lipase in this paper. The effects of microwave heating of wheat bran on the lipase activities, gluten properties, dough properties and storage stability of the stabilized whole wheat flour, and the quality of steamed bread made of stabilized whole wheat flour were investigated. Furthermore, molecular docking was applied to interpret the mechanism. The results showed that microwave can reduce lipase activity, maintain the quality of whole wheat flour dough and steamed bread, and retard rancidity. The molecular docking results displayed that the conformation of the amino acids chains near the lipase catalytic center changed, which made the substrate difficult to enter the catalytic center and prevented the hydrolysis of the fat substrate.
Comprehensive evaluation for the one-pot biosynthesis of butyl acetate by using microbial mono- and co-cultures
Authors: Lv Yang , Jiang Yujia , Lu Jiasheng , Gao Hao , Dong Weiliang , Zhou Jie , Zhang Wenming , Xin Fengxue , Jiang Min 
Published: October 2021

Abstract
Background
Butyl acetate has shown wide applications in food, cosmetics, medicine, and biofuel sectors. These short-chain fatty acid esters can be produced by either chemical or biological synthetic process with corresponding alcohols and acids. Currently, biosynthesis of short chain fatty acid esters, such as butyl butyrate, through microbial fermentation systems has been achieved; however, few studies regarding biosynthesis of butyl acetate were reported.

Results
In this study, three proof-of-principle strategies for the one-pot butyl acetate production from glucose through microbial fermentation were designed and evaluated. (1) 7.3 g/L of butyl acetate was synthesized by butanol-producing Clostridium acetobutylicum NJ4 with the supplementation of exogenous acetic acid; (2) With the addition of butanol, 5.76 g/L of butyl acetate can be synthesized by acetate-producing Actinobacillus succinogenes130z (ΔpflA); (3) Microbial co-culture of C. acetobutylicum NJ4 and A. succinogenes130z (ΔpflA) can directly produce 2.2 g/L of butyl acetate from glucose by using microbial co-culture system with the elimination of precursors. Through the further immobilization of A. succinogenes130z (ΔpflA), butyl acetate production was improved to 2.86 g/L.

Conclusion
Different microbial mono- and co-culture systems for butyl acetate biosynthesis were successfully constructed. These strategies may be extended to the biosynthesis of a wide range of esters, especially to some longer chain ones.
Severe re-expansion pulmonary edema despite incomplete re-expansion of the lung: a case report
Authors: Zabielna Alicja 
Published: October 2021

AbstractBackgroundRe-expansion pulmonary edema is a rare but potentially fatal (mortality up to 20%) complication of the rapid removal of air, fluid, or other space-occupying lesion from the pleural cavity. This case report highlights the fact that this complication is much more likely to occur when treating large, chronic pneumothoraces, and can occur even if the lung fails to fully re-expand.Case presentationA 49-year-old white British man presented to the emergency department with sudden onset of shortness of breath 5 days prior to admission. A left-sided pneumothorax was suspected on clinical examination, and chest X-ray confirmed a large, left-sided pneumothorax. A 12 French gauge chest drain was inserted and connected to an underwater seal. Shortly after insertion of the drain, the patient’s condition deteriorated rapidly with tachypnea and severe hypoxemia. A diagnosis of re-expansion pulmonary edema was made, and the patient was treated with high-flow oxygen and continuous positive airways pressure.ConclusionsThis case report serves as a reminder of the morbidity and potential mortality associated with a commonly performed medical procedure, and reveals a lack of clear and precise guidance on the management of large, chronic (> 72 hours) pneumothoraces in the current British Thoracic Society pleural disease guidelines.
PSENet-based efficient scene text detection
Authors: Liao Guanglong , Zhu Zhongjie , Bai Yongqiang , Liu Tingna , Xie Zhibo 
Published: October 2021

AbstractText detection is a key technique and plays an important role in computer vision applications, but efficient and precise text detection is still challenging. In this paper, an efficient scene text detection scheme is proposed based on the Progressive Scale Expansion Network (PSENet). A Mixed Pooling Module (MPM) is designed to effectively capture the dependence of text information at different distances, where different pooling operations are employed to better extract information of text shape. The backbone network is optimized by combining two extensions of the Residual Network (ResNet), i.e., ResNeXt and Res2Net, to enhance feature extraction effectiveness. Experimental results show that the precision of our scheme is improved more than by 5% compared with the original PSENet.
Kuratowski MNC method on a generalized fractional Caputo Sturm–Liouville–Langevin q-difference problem with generalized Ulam–Hyers stability
Authors: Boutiara Abdelatif , Benbachir Maamar , Etemad Sina , Rezapour Shahram 
Published: October 2021

AbstractIn this work, we consider a generalized quantum fractional Sturm–Liouville–Langevin difference problem with terminal boundary conditions. The relevant results rely on Mönch’s fixed point theorem along with a theoretical method by terms of Kuratowski measure of noncompactness (MNC) and the Banach contraction principle (BCP). Furthermore, two dynamical notions of Ulam–Hyers (UH) and generalized Ulam–Hyers (GUH) stability are addressed for solutions of the supposed Sturm–Liouville–Langevin quantum boundary value problem (q-FBVP). Two examples are presented to show the validity and also the effectiveness of theoretical results. In the last part of the paper, we conclude our exposition with some final remarks and observations.
The new normal of web camera theft on campus during COVID-19 and the impact of anti-theft signage
Authors: Chernoff William A. 
Published: October 2021

Abstract
Objective
The opportunity for web camera theft increased globally as institutions of higher education transitioned to remote learning during COVID-19. Given the thousands of cameras currently installed in classrooms, many with little protection, the present study tests the effectiveness of anti-theft signage for preventing camera theft.

Methods
Examined web camera theft at a southern, public university located in the United States of America by randomly assigning N = 104 classrooms to receive either anti-theft signage or no signage. Camera theft was analyzed using Blaker’s exact test.

Results
Classrooms not receiving anti-theft signage (control) were 3.42 times more likely to exhibit web camera theft than classrooms receiving anti-theft signage (medium effect size).

Conclusions
Using classrooms as the unit of analysis presents new opportunities for not only future crime prevention experiments, but also improving campus safety and security. Also, preventing web camera theft on campus is both fiscally and socially responsible, saving money and ensuring inclusivity for remote learners.
Development of the pharmacogenomics and genomics literacy framework for pharmacists
Authors: Rahma Azhar T. , Elbarazi Iffat , Ali Bassam R. , Patrinos George P. , Ahmed Luai A. , Elsheik Mahanna , Al-Maskari Fatma 
Published: October 2021

AbstractBackgroundPharmacists play a unique role in integrating genomic medicine and pharmacogenomics into the clinical practice and to translate pharmacogenomics from bench to bedside. However, the literature suggests that the knowledge gap in pharmacogenomics is a major challenge; therefore, developing pharmacists’ skills and literacy to achieve this anticipated role is highly important. We aim to conceptualize a personalized literacy framework for the adoption of genomic medicine and pharmacogenomics by pharmacists in the United Arab Emirates with possible regional and global relevance.ResultsA qualitative approach using focus groups was used to design and to guide the development of a pharmacogenomics literacy framework. The Health Literacy Skills framework was used as a guide to conceptualize the pharmacogenomics literacy for pharmacists. The framework included six major components with specific suggested factors to improve pharmacists’ pharmacogenomics literacy. Major components include individual inputs, demand, skills, knowledge, attitude and sociocultural factors.ConclusionThis framework confirms a holistic bottom-up approach toward the implementation of pharmacogenomics. Personalized medicine entails personalized efforts and frameworks. Similar framework can be created for other healthcare providers, patients and stakeholders.
Accelerated ageing of paper: effect of lignin content and humidity on tensile properties
Authors: Małachowska Edyta , Dubowik Marcin , Boruszewski Piotr , Przybysz Piotr 
Published: October 2021

Abstract
Paper degradation menaces the useful lifetime of books, manuscripts, and works on paper during storage, circulation, and display in libraries, archives, and museums. Severe damages such as embrittlement, decay, and mold often occur to the paper that might threaten to lose cultural heritage. However, the shelf life of papers stored in suitable conditions can be extended by hundreds of years. The most important external factors affecting the deterioration of paper-based materials include, in particular, changes in temperature and air humidity. In this study, the effects of accelerated aging under different conditions, including substantially different relative humidity, were considered relative to the strength properties of the paper sheets. These include the mechanical strength, such as breaking length, tear resistance, and bursting strength of the paper samples before and after dry heat aging and hydrothermal aging. Samples with various content of lignin produced in neutral pH were examined to exclude the adverse influence of acidity on paper properties. The results indicate that impact of moisture on tensile properties and pH-value of paper is much greater than the effect of increased temperature. The results of this work are intended to consolidate and expand the theoretical foundation and provide technical support for the conservators and library staff on the storage of paper cultural relics.
Machine learning-based identification of patients with a cardiovascular defect
Authors: Louridi Nabaouia , Douzi Samira , El Ouahidi Bouabid 
Published: October 2021

AbstractCardiovascular diseases had been for a long time one of the essential medical problems. As indicated by the World Health Association, heart ailments are at the highest point of ten leading reasons for death. Correct and early identification is a vital step in rehabilitation and treatment. To diagnose heart defects, it would be necessary to implement a system able to predict the existence of heart diseases. In the current article, our main motivation is to develop an effective intelligent medical system based on machine learning techniques, to aid in identifying a patient’s heart condition and guide a doctor in making an accurate diagnosis of whether or not a patient has cardiovascular diseases. Using multiple data processing techniques, we address the problem of missing data as well as the problem of imbalanced data in the publicly available UCI Heart Disease dataset and the Framingham dataset. Furthermore, we use machine learning to select the most effective algorithm for predicting cardiovascular diseases. Different metrics, such as accuracy, sensitivity, F-measure, and precision, were used to test our system, demonstrating that the proposed approach significantly outperforms other models.
The impact of virtual reality meditation on college students’ exam performance
Authors: Kaplan-Rakowski Regina , Johnson Karen R. , Wojdynski Tomasz 
Published: October 2021

AbstractAdvocates of meditation claim that it can improve various aspects of life, including health, attention, thinking, and learning. The purpose of this empirical, quantitative, between-subject study was twofold. First, it compared the effectiveness of meditation delivered through virtual reality versus video, as measured by students’ test scores. Second, the study provided insights on the use of meditation, whether via virtual reality or video, as a way to positively affect well-being.T-test analysis showed virtual reality meditation to be significantly more beneficial than video meditation. Students reported that meditation techniques delivered using either medium to be helpful in decreasing their pre-exam anxiety. This study has practical implications and offers evidence on the beneficial impact of VR meditation on students’ exam performance and anxiety levels.
Mathematics self-concept and challenges of learners in an online learning environment during COVID-19 pandemic
Authors: Bringula Rex , Reguyal Jon Jester , Tan Don Dominic , Ulfa Saida 
Published: October 2021

AbstractIn this mixed-methods research, the relationship between four factors of individual online learners and their mathematics self-concept was explored. In addition, the challenges the students faced in learning mathematics online during the Coronavirus disease (COVID-19) pandemic were determined. The participant students were from two mathematics classes offered online during the summer of 2020. Pure online classes were first offered during this period because face-to-face learning sessions were suspended due to the COVID-19 pandemic. It was found that students owned the devices they were using for online classes. Internet connection and power interruption were the most problematic aspects of online learning. Students had positive as well as negative mathematics online learning self-concepts. Individual factors were partly related to mathematics self-concept. Qualitative data shows that students faced technological, personal, domestic, assessment, pedagogical, consultation, and test anxiety challenges. Implications and recommendations for teaching mathematics in an online environment are offered.
Evaluation of regenerated cartilage using T2 mapping methods after opening-wedge high tibial osteotomy with microfracture at the cartilage defect: a preliminary study
Authors: Iida Ken , Hashimoto Yusuke , Nishida Yohei , Yamasaki Shinya , Nakamura Hiroaki 
Published: October 2021

Abstract
Purpose
This study evaluated the regenerated cartilage after opening-wedge high tibial osteotomy (OWHTO) with concomitant microfracture by second-look arthroscopy, Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score and magnetic resonance imaging (MRI) T2 mapping. It was hypothesised that cartilage regeneration can be achieved by HTO, but the quality of regenerated cartilage is not normal cartilage.

Methods
OWHTO was performed in eight knees of seven patients (mean age, 57.6 ± 5.2 years). Microfracture for the cartilage defect was performed followed by OWHTO, and second-look arthroscopy was performed at the time of plate removal (14.1 ± 4.5 months after OWHTO). MRI was assessed at three months and one year after surgery. The status of articular cartilage regeneration was assessed by the ICRS grade, MOCART score and T2 value.

Results
The number of subjects in ICRS grade 1/2/3/4 changed significantly from 0/0/4/4 preoperatively to 0/2/6/0 postoperatively in the medial femoral condyle (MFC) (P < 0.05) and 0/0/0/8 preoperatively to 0/0/7/1 postoperatively in the medial tibial plateau (MTP) (P < 0.05). Mean MOCART scores for MFC and MTP at one year after surgery exhibited significant increases compared with the results at three months after surgery. Mean T2 values for MFC and MTP did not differ at three months and one year after surgery.

Conclusion
The appearance and morphological evaluation by ICRS grade and MOCART score of regenerated cartilage were improved after OWHTO with concomitant microfracture. However, there were no significant qualitative differences in T2 values. This suggests that the regenerated cartilage tissue was likely to be insufficient cartilage.

Level of evidence
Level IV, therapeutic case series.
Choroidal thickness in relation to urinary albumin excretion rate in type 2 diabetes mellitus without retinopathy
Authors: Ashour Doaa Maamoun , El-Shazly Amany Abd El-Fattah , Abdelgawad Randa Hesham Ali , Saleh Mohamed Ibrahim 
Published: October 2021

Abstract
Background
To evaluate choroidal thickness (CT) in diabetic patients without diabetic retinopathy (DR) in relation to the urinary albumin excretion rate (UAER).

Methods
This is a prospective case-control study that included a consecutive sample of 120 patients with type 2 diabetes without clinically evident DR and a group of 60 matched healthy controls. Diabetic patients were included in two groups according to their UAER (normoalbuminuria and microalbuminuria). Complete ophthalmological examination was performed followed by optical coherence tomography (SD-OCT) for retinal and choroidal assessment. Twenty-four-hour urine samples were collected for UAER and blood samples for HbA1c and serum creatinine were obtained.

Results
The study included 180 eyes from 180 subjects in three groups. Patients with higher levels of albuminuria had a thinner choroid than normal controls, with decremental thinning as albuminuria progressed. Diabetics with normoalbuminuria showed no significant differences from controls. Choroidal thickness showed a significant moderate negative correlation with UAER (r  =  − 0.58, p  <  0.001). Multiple regression analyses for diabetic patients with microalbuminuria demonstrated that UAER is the most important determinant of subfoveal choroidal thickness (SFCT) (p  <  0.001).

Conclusions
Decreased CT was significantly correlated with UAER in diabetic patients without retinopathy and otherwise normal kidney functions. This decrease in thickness might be a predictor of DR.
Veno-venous extracorporeal membrane oxygenation in the management of refractory bilateral bronchial dehiscence after lung transplant: a case report
Authors: Tani Makiko 
Published: October 2021

Abstract
Background
Bronchial dehiscence is a life-threatening complication after lung transplant. If it is not treated by placement of stent or reanastomosis, the chance of survival will depend on the availability of a new graft. However, retransplant is not a practical management option in Japan, where waiting time for lung transplant is extensive. We described a case of refractory bilateral bronchial dehiscence managed by veno-venous extracorporeal oxygenation membrane (VV ECMO) while allowing the dehiscence to heal.

Case presentation
A 25-year-old man with idiopathic pulmonary arterial hypertension underwent a bilateral lung transplant. The patient developed bilateral bronchial dehiscence. Open reanastomosis was not successful, and air leakage recurred under low positive pressure ventilation. VV ECMO was established to maintain oxygenation with spontaneous breathing until both dehiscence were closed by adhesions.

Conclusion
In a patient with refractory bilateral bronchial dehiscence, VV ECMO may provide bronchial rest and serve as a bridge therapy to recovery.
High-resolution neuromuscular ultrasound-based diagnosis of carpal tunnel syndrome in a sample of Egyptian population
Authors: ElSadek Ahmed , Fathy Mai , AbdElMoneim Amr 
Published: October 2021

Abstract
Background
Carpal tunnel syndrome is the commonest entrapment neuropathy. The cut-off point of cross-sectional area to diagnose carpal tunnel syndrome may vary among populations. The objective of this study was to determine the best cut-off point of median nerve cross-sectional area to diagnose carpal tunnel syndrome among Egyptian population and to compare the difference of median nerve cross-sectional area in diabetic patients versus healthy individuals.

Results
Mean cross-sectional area was 7.78 ± 1.260 mm2 among healthy individuals and 8 ± 1.018 mm2 among diabetics. Cut-off cross-sectional area of median nerve above which compression is anticipated is 9.5 mm2.

Conclusion
Ultrasound can be used to diagnose carpal tunnel syndrome by measuring the median nerve cross-sectional area.