bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Progesterone Receptor Expression on Platinum Sensitivity and Survival Outcomes in Patients With Ovarian Clear Cell Carcinoma
Authors: Wu Chen-Hsuan , Fu Hung-Chun , Ou Yu-Che , Lan Jui , Lin Hao 
Published: July 2021

Abstract
BackgroundOvarian clear cell carcinoma (OCCC) is considered to be a relatively platinum-resistant malignancy. In the present study, we investigated the impact of progesterone receptor (PR) expression on platinum sensitivity and survival outcomes in patients with OCCC.MethodsWe retrospectively reviewed 80 patients with OCCC who underwent surgery followed by adjuvant chemotherapy, and analyzed PR expression by immunohistochemical staining. The PR expression was quantified using the H-score. The platinum sensitivity and survival outcomes were compared between those with a weak and strong PR expression. Cisplatin viability experiments were performed in OCCC cell lines (TOV-21G) with different PR expressions.ResultsAmong the 80 patients, 66 and 14 were considered to have platinum-sensitive and platinum-resistant disease, respectively. The mean PR H-score of the platinum-sensitive tumors was significant higher than that of the platinum-resistant tumors (p=0.002). Although there were no significant differences in progression-free and overall survival between the patients with high and low PR expressions, the patients with a high PR expression had a trend towards better survival. In cell models, PR protein was weakly detectable in TOV-21G cells. Through transfection of PR gene, TOV-21G cells were shown to have a strong PR expression by Western blot analysis. After treating the TOV-21G cells with cisplatin, we found that the overexpression of PR enhanced cisplatin cytotoxicity. ConclusionsThe patients in this study with a strong PR expression were associated with better platinum sensitivity and survival, and this was compatible with our experimental findings. The value of PR as a tumor sensitizer to cisplatin in OCCC should be further investigated.
WITHDRAWN: Map-Reduce based Distance Weighted k-Nearest Neighbor Machine Learning Algorithm for Big Data Applications
Authors: E Gothai , Moorthy Usha , E Sathishkumar V , Alnuaim Abeer Ali , Hatamleh Wesam Atef , Sweidan Dirar 
Published: July 2021

Abstract
With the evolution of Internet standards and advancements in various Internet and mobile technologies, especially since web 4.0, more and more web and mobile applications emerge such as e-commerce, social networks, online gaming applications and Internet of Things based applications. Due to the deployment and concurrent access of these applications on the Internet and mobile devices, the amount of data and the kind of data generated increases exponentially and the new era of Big Data has come into existence. Presently available data structures and data analyzing algorithms are not capable to handle such Big Data. Hence, there is a need for scalable, flexible, parallel and intelligent data analyzing algorithms to handle and analyze the complex massive data. In this article, we have proposed a novel distributed supervised machine learning algorithm based on the MapReduce programming model and Distance Weighted k-Nearest Neighbor algorithm called MR-DWkNN to process and analyze the Big Data in the Hadoop cluster environment. The proposed distributed algorithm is based on supervised learning performs both regression tasks as well as classification tasks on large-volume of Big Data applications. Three performance metrics, such as Root Mean Squared Error (RMSE), Determination coefficient (R2) for regression task, and Accuracy for classification tasks are utilized for the performance measure of the proposed MR-DWkNN algorithm. The extensive experimental results shows that there is an average increase of 3–4.5% prediction and classification performances as compared to standard distributed k-NN algorithm and a considerable decrease of Root Mean Squared Error (RMSE) with good parallelism characteristics of scalability and speedup thus, proves its effectiveness in Big Data predictive and classification applications.
Malignant Transformation of Liver Cysts Into Cholangiocarcinoma During Follow-up: Potential Dangers of Liver Cysts
Authors: Liu Fu-sheng , Li Ke-lu , He Yue-ming , Zhang Zhong-lin , Yuan Yu-feng , Wang Hai-tao 
Published: July 2021

Abstract
Background: The liver cyst is a common disease in hepatobiliary surgery. Most patients have no apparent symptoms and are usually diagnosed accidentally during imaging examinations. The vast majority of patients with liver cysts follow a benign course, with very few serious complications and rare reports of malignant changes. Case Presentation: We present two cases of liver cysts that evolved into intrahepatic tumors during the follow-up process. The first patient had undergone a fenestration and drainage operation for the liver cyst, and the cancer was found at the cyst’s position in the third year after the procedure. Microscopically, bile duct cells formed the cyst wall. Tumor cells can be seen on the cyst wall and its surroundings to form adenoid structures of different sizes, shapes, and irregular arrangements, some of which are arranged in clusters. The second patient was regularly rechecked after discovering liver cysts, and a new mass appeared very close to the cyst. The clinical manifestations and laboratory examinations of the two patients lacked specificity, the preoperative diagnosis was unclear, and the postoperative pathology confirmed cholangiocarcinoma.Conclusions: Our cases indicate that liver cysts may lead to the occurrence of malignant intrahepatic cholangiocarcinoma. Therefore, follow-up of particular liver cysts is necessary, and the differential diagnosis of the intrahepatic cystic tumors needs to include cholangiocarcinoma.
Desmoplastic Small Round Cell Tumor of the Head and Neck: A Clinicopathological, Immunohistochemical and Molecular Analysis of Three Cases with Literature Review
Authors: Sun Meng , Jiang Xue-bing , Shao Meng-yuan , Wang Qi-feng , Zhao Lu , Liu Jia-han , Lao I Weng , Yu Lin , Wang Jian 
Published: July 2021

Abstract
Background: Desmoplastic small round cell tumor (DSRCT) is a rare aggressive malignancy typically originating from the abdominal or pelvic cavity. DSRCT presenting as a primary head and neck tumor has rarely been described in the literature. Case presentation: We present three cases of DSRCT arising in the head and neck to further characterize its clinicopathological features. All three patients were male and aged 36, 30 and 17 years. The involved sites included the orbit (1 case) and submandibular gland (2 cases). The tumors ranged in size from 2.4 to 3.5 cm (mean, 2.1 cm). Histologically, all tumors showed irregular-shaped, variable-sized nests of small round cells deposited in an abundant desmoplastic stroma. Tumor cells contained small hyperchromatic nuclei and scant amounts of eosinophilic cytoplasm with inconspicuous nucleoli. Immunohistochemically, the tumors were positive for AE1/AE3 (3/3), desmin (3/3), vimentin (2/2), NSE (1/1) and EMA (1/1). Fluorescence in situ hybridization (FISH) analysis demonstrated the presence of EWSR1 and WT1 rearrangements in all three cases. All patients received surgery and adjuvant chemotherapy and/or radiotherapy. There was no evidence of recurrence and metastasis in two patients, and the third suffered lung metastasis.Conclusions: DSRCT arising in the head and neck represents an extremely rare condition. It is easily mistaken as poorly differentiated carcinoma due to similar morphology and expression of epithelial markers. Immunohistochemistry assay in conjunction with molecular detection of EWSR1-WT1 fusion will be helpful for arriving at an accurate diagnosis to avoid misdiagnosis and inappropriate treatment.
Pneumatosis Cystoides Intestinalis Accompanied by Schistosomiasis: A Case Report
Authors: Yuan Chunyan , Huang Zhongyue , Liu Qiping , Du Ling , Xie Xiaoli , Jiang Xuebing , Liu Jun , Sheng Xia , Wang Xuming 
Published: July 2021

Abstract
Background: Pneumatosis cystoides intestinalis (PCI) is a rare disease that occurs frequently in the large and small intestine and has no obvious clinical symptoms. It is difficult to preoperatively diagnose and is easily undiagnosed or misdiagnosed. The main pathological features are air-bearing cysts in the intestinal submucosa, intermuscular wall and subserous membrane. Case presentation: PCI is a rare disease, which often occurs in the large intestine and small intestine，without obvious clinical symptoms. It is difficult to diagnose before operation and is easy to be missed and misdiagnosed. Duvernoi first described the disease in 1730. The main pathological features were air-bearing cysts in intestinal submucosa, intermuscular wall and subserous membrane. Conservative treatment is the first choice when there are no serious complications, and timely surgical treatment is needed for serious and life-threatening complications. This report presents the clinical and pathological analysis of PCI in a 92-year-old man. The patient was admitted to hospital because of acute peritonitis,and was diagnosed as PCI with schistosomiasis after emergency operation. Postoperative follow-up is generally in good condition.Conclusions: The incidence of PCI is low. Because of a lack of specificity in clinical manifestations and endoscopic findings, PCI is difficult to diagnose preoperatively and is easily missed and misdiagnosed. Conservative treatment is the first choice when there are no serious complications; however, timely surgical treatment is required for serious and life-threatening complications.PCI treatment is effective andconvenient, and the prognosis is optimistic. Therefore, clinicians should increase their awareness of PCI to avoid unnecessary misdiagnosis.
Dynamic Picking and Storage Optimization of Robotic Picking Systems
Authors: Chi Cheng , Wu Shasha , Xia Delong , Wu Yaohua 
Published: July 2021

Abstract
With the development of e-commerce and the improvement of logistics requirements, more and more ‘parts-to-picker’ picking systems begin to replace the inefficient ‘picker-to-parts’ picking systems in various scenarios. As the mainstream ‘parts-to-picker’ system, the robotic mobile fulfillment system has been attracting much attention in recent years. In addition to the customer's changing requirements, the rapid response of the picking system to the order is particularly important. In the above context, to seek a breakthrough in the picking system's picking efficiency without increasing the cost of additional equipment, the storage allocation of the pods becomes very important. This article focuses on the dynamic storage allocation of robotic mobile fulfillment system, which has positive theoretical and practical significance. By analyzing the pod storage process of the robotic mobile fulfillment system, a dynamic pod storage allocation model suitable for the robotic mobile fulfillment system is established with the goal of minimizing the pod handling distance. Two dynamic pod storage allocation strategies are proposed for the system. By simulating the picking systems of different scales, the effectiveness of the dynamic storage allocation strategy is verified, which has a certain reference to the operation of the robotic mobile fulfillment system in practice.
Dual Mobility Cups Present Promising Outcomes in Primary Total Hip Arthroplasty Patients At A Risk of Dislocation
Authors: Moon Nam Hoon , Do Min Uk , Kim Jung Shin , Seo Jae Seung , Shin Won Chul 
Published: July 2021

Abstract
Introduction

This study aimed to evaluate the early results of primary total hip arthroplasty (THA) using dual mobility (DM) cups in patients at a risk of dislocation and compare them with that of fixed bearing (FB) THA.
Materials and methods

This retrospective study included patients who had undergone primary THA between January 2016 and December 2018 and were at a risk of dislocation. A propensity score-matched analysis was conducted for 63 THA procedures with vitamin-E infused highly cross-linked polyethylene (VEPE) DM bearing and 63 THA procedures performed with FB from the same manufacturer for a mean follow-up period of 3.1 and 3.5 years, respectively. The radiologic outcomes at the last follow-up and incidence of postoperative complications were evaluated and compared statistically between the two groups. The modified Harris hip score (mHHS) was used to assess patient-reported outcomes.
Results

Postoperative dislocation occurred in 4 cases (6.3%) in the FB group, but did not occur in the DM group (p = 0.042). There was no difference in the radiologic outcomes and postoperative complications between the two groups. The mHHS at the last follow-up showed satisfactory outcomes in both the groups (DM group, 90.5; FB group, 88.1), without a statistical difference between the groups.
Conclusion

The early results of THA using VEPE DM bearing showed better outcomes than that of THA with FB for patients at a risk of dislocation. A longer follow-up period is recommended to assess the stability and overall outcomes.
Olfactory Dysfunction After Oral and Maxillofacial Surgery
Authors: Wang Yaxi , Li Hua , Huang Xuanping , Zhou Nuo 
Published: July 2021

Abstract
Background: Although anesthesia can contribute to olfactory dysfunction, it is a rare complication after oral and maxillofacial surgery by general anesthesia.Cases presentation: In this study, we introduced 3 cases of patient suffering from anosmia (complete loss of smell), after oral and maxillofacial surgery by general anesthesia. We also investigated possible etiologies of anosmia. Conclusions: There are some evidences that anosmia is caused by nasotracheal intubation, which may cause OM injury and/or swing of the nasal septum in patients with nasal septum deviation. Olfactory dysfunction via general anesthetic drugs, however, may have a different etiology.
Electroencephalogram (EEG) Controlled Anatomical Robot Hand
Authors: Herath H.M.K.K.M.B. , de Mel W.R. 
Published: July 2021

Abstract
Today, millions of peoples are suffering due to the lack of a functional arm preventing from doing things. In Sri Lanka there are about over thousands of people are suffering from disabilities. Sri Lanka Ministry of Health state that the number of disabled persons in Sri Lanka will be increased by 24.2% by 2025. Most of them will suffer from hand disabilities. Disabling a hand costs huge disadvantages to a human being. Living without a hand will be a major problem for those who having hand disabilities. The aim of this project is to give a solution to those who suffer from hand disabilities and make their life efficient and easy. The biosignal-based controlling system is the next step in order to achieve more accuracy. Bio-signals are referring as the Electroencephalography (EEG), Electromyogram (EMG) and Electrocardiogram (ECG) signals. The robot hand motions and movements of the fingers will be completely dependent on the brainwaves which human beings will produce. This project mainly focused on Electroencephalography (EEG) signals also known as the brain waves. The methodology of this project is based on the field of robotics, artificial intelligence (AI), anatomy, neuroanatomy, and biosignal.
Macrophage Polarization-Related Gene Signature for Risk Stratification and Prognosis of Survival in Gliomas
Authors: Zhang Jingwei , Li Shuwang , Liu Fangkun 
Published: July 2021

Abstract
Macrophage polarization plays an essential role in tumor immune cells infiltration and tumor growth. We selected a series of genes distinguishing between M1 and M2 macrophage and explored their prognostic value in gliomas. A total of 170 genes were included in our study. CGGA database was used as the training cohort, and the TCGA database as the validation cohort. The biological processes and functions were identified by GO and KEGG analysis. Kaplan-Meier analysis was used to compare survival differences between groups. Finally, GEPIA was applied to explore immune infiltrates in the tumor microenvironment. Importantly, we re-verified the results using our sequencing data. We build a risk score model using Cox regression analysis based on the CGGA and verified in the TCGA database and our sequencing data. Patients with gliomas in the high-risk group were associated with high grade, IDH WT status, MGMT promoter unmethylation, 1p19q non-codeletion, and prone to have a poor outcome. Moreover, these genes play an essential role in immune infiltrations in LGG and GBM microenvironments. Macrophage polarization-related gene signature can predict the malignancy and outcome of patients with gliomas and might act as a promising target for glioma immunotherapy in the future.
Prognostic Factors for Successful Percutaneous Disc Decompression Using the Navigable Device L’DISQ in Patients with Lumbar Discogenic Pain
Authors: Kim Ji Yeong , Lee Ku Sang , Jung Sang Min , Kim Young Hoon 
Published: July 2021

Abstract
The navigable percutaneous disc decompression (PDD) device L’DISQ is an effective and safe option for the treatment of lumbar discogenic pain. This retrospective study aimed to evaluate the prognostic factors associated with the successful outcome of PDD using the L’DISQ for treating lumbar discogenic pain by following up patients before and 1, 2, 3, and 6 months after the procedure. A successful outcome was defined as a ≥ 50% reduction in the numeric rating scale scores for pain and a ≥ 40% reduction in the Oswestry disability index scores at 6 months after the procedure. Clinical parameters and patient demographics, including pain duration, history of surgery, number of treatment levels, and radiographic findings of lumbar magnetic resonance imaging, were also examined. Of the 106 patients included, 80 (75.5%) had successful outcomes at 6 months. Multivariable logistic regression analysis revealed that the presence of high-intensity zones (HIZs) (P = 0.016) was an independent positive predictor of successful PDD outcomes; conversely, migration of the herniated disc (P = 0.017) and bilaterally herniated discs (P = 0.001) were negative predictors. Therefore, the presence of HIZs, absence of migration of herniated discs, and presence of unilaterally herniated discs are positive predictors of successful outcomes.
Multifocal Pancreatic and Liver PEComas Mimic Metastatic Tumors: Case Report and Literature Review
Authors: Guan Jian , Shen Guihua , Huang Wenting 
Published: July 2021

Abstract
Background: Perivascular epithelioid cell tumor (PEComa) is a mesenchyme tumor derived from soft tissues and organs. Its morphology includes several types such as angiomyolipoma, lymphangiomyomatosis and pulmonary clear-cell “sugar” tumor with similar immunophenotype. Multifocal PEComas are rare lesions, which would confuse imaging examination and clinical management. We reported a case of multifocal angiomyolipomas in the pancreas and liver in a young patient. And we reviewed the literature to explore the clinicopathological characteristics and possible pathogenesis of multifocal PEComas.Case presentation: A 28-year-old woman presented with a lesion in the head of the pancreas and liver 5/6 segment respectively, initially suspected of a pancreatic tumor with liver metastasis. To explore the nature of the lesion, a liver mass resection and a pancreatic mass biopsy were performed at the first operation. After the postoperative pathology was confirmed as an epithelioid angiomyolipoma, the patient underwent a pancreatic segmental resection. After the operation, the patient did not receive any adjuvant treatment and was followed up for 25 months without tumor recurrence or metastasis.Conclusion: Multifocal PEComas present a chronic clinical course and have a good prognosis. Surgical resection is the main treatment. In the diagnosis, in addition to metastatic tumors, multifocal lesions also need to be differentiated with multifocal PEComa; in the treatment, radical treatment should not be performed for this type of disease; in the long-term monitoring of the disease, it is necessary to consider the possibility of a second or a greater number of PEComa lesions even many years later.
Large eddy simulation of flow around semi-conical piers vertically mounted on the bed
Authors: Aghaee-Shalmani Yasin , Hakimzadeh Habib 
Published: July 2021

Abstract
In this paper, details, and results of three-dimensional numerical modeling of flow around the semi-conical piers vertically mounted on the bed in a channel, are presented. For flow simulation, 3-D Navier-Stokes equations are solved numerically using the finite volume method and large eddy simulation (LES). In this study, the semi-conical piers with different side slope angles are tested, and the flow around them is compared with the cylindrical reference pier. Flow structures, vortex shedding behind piers, horseshoe vortices, instantaneous and time-averaged flow structures are presented and discussed. Numerical model results show that the semi-conical piers are eventuated remarkable reduction (up to 25%) in downward flow velocity in the upstream side of the piers, and much more reduction (up to 46%) in bed shear stresses in comparison with the cylindrical pier. Moreover, the model results showed some decrease in vortex shedding frequency for the semiconical piers compared to the cylindrical pier.
Reactive orange 12 dye adsorption onto magnetically separable CaFe2O4 nanoparticles synthesized by simple chemical route: kinetic, isotherm and neural network modeling
Authors: Das Payel , Debnath Animesh 
Published: July 2021

AbstractIndustrial wastewaters laden with toxic dyes are required to be treated prior to their disposal in view of their adverse effect on human health and aquatic ecosystems. Thus in this research, CaFe2O4 nanoparticles were prepared and used as adsorbent for elimination of reactive orange 12 dye (RO12) from aqueous medium. The CaFe2O4 nanoparticles exhibit specific surface area of ∼230 m2/g and average pore diameter of ∼2.5 nm. Maximum RO12 removal of 77% was observed at solution pH 2.0 with uptake capacity of 276.92 mg/g. The electrostatic interaction between CaFe2O4 nanoparticles and RO12 was the main driving force behind this adsorption. The kinetic modeling reveals that this adsorption process obeyed the pseudo-second-order kinetic model accurately (R2: 0.988–0.994), indicating chemisorption behavior. The adsorption experimental data firmly followed the Langmuir isotherm model (R2: 0.997), confirming monolayer adsorption. Thermodynamic study suggests that the adsorption process is spontaneous (ΔG0 = −8.76 to −3.19 kJ/mol) and exothermic in nature (ΔH0 = –71.86 kJ). A neural network model (optimum topology of 4–7–1) was developed for precise forecasting of RO12 removal (%). The developed model with very high correlation coefficient (0.986) and very low mean squared error (0.00185) was successful for accurate prediction of experimental data.