bluuebunny/crossref_metadata_2025_split huggingface dataset:
The scope and nature of sexual orientation and gender identity and expression change efforts: a systematic review protocol
Authors: Kinitz David J. , Salway Travis , Dromer Elisabeth , Giustini Dean , Ashley Florence , Goodyear Trevor , Ferlatte Olivier , Kia Hannah , Abramovich Alex 
Published: January 2021

Abstract
Background
Sexual orientation and gender identity and expression change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or gender expressions of sexual and gender minorities (SGM). SOGIECE are associated with significant adverse health and social outcomes. SOGIECE continue to be practiced around the world, despite denouncements from professional bodies and survivors, as well as calls for legislative advocacy to prohibit SOGIECE and protect SGM. There are substantial gaps in the availability of consolidated international research to support and refine legislative proposals related to SOGIECE, including those currently underway to enforce bans in Canada and elsewhere.
We therefore propose the first systematic review of international data on SOGIECE that will outline the scope and nature of these practices worldwide. Specifically, we aim to estimate how many SGM have been exposed to SOGIECE, which sub-groups of SGM experience higher rates of SOGIECE, and how estimates of SOGIECE vary over time and place. In addition, we aim to describe when, where, how, and under what circumstances SGM are exposed to SOGIECE.

Methods
To locate an interdisciplinary swath of papers, nine (9) bibliographic databases will be searched: Medline (OVID), Embase (OVID), PsycInfo and Social Work Abstracts via EBSCO, CINAHL, Web of Science Core Collection, LGBTQ+ Source, and Proquest Dissertations & Theses Global and Sociology Collection (ProQuest). A gold standard search will be developed for Medline and adapted to the other databases. Grey literature will be searched at relevant websites, and reference harvesting will be performed in relevant SOGIECE scientific consensus statements. Two authors will independently screen abstracts/titles, screen full texts, abstract data, and apply risk of bias assessments. A narrative synthesis will be implemented to summarize findings.

Discussion
This review will address the gap in synthesized data regarding the prevalence of SOGIECE, social correlates of SOGIECE, variations of SOGIECE over time and place, and the circumstances, settings, and time-points of SOGIECE exposure. Findings from this review will directly inform ongoing and new legislative efforts to ban SOGIECE and other interventions that aim to stem SOGIECE practices and support SOGIECE survivors.

Systematic review registration
Registration with PROSPERO can be found under the registration number: CRD42020196393.
Bioassay-guided isolation and identification of anti-obesity phytochemicals from fruits of Amomum tsao-ko
Authors: Hong Seong Su , Choi Chun Whan , Lee Ji Eun , Jung Yeon Woo , Lee Jung A. , Jeong Wonsik , Choi Yun-Hyeok , Cha Hanna , Ahn Eun-Kyung , Oh Joa Sub 
Published: January 2021

AbstractAmomum tsao-ko (Zingiberaceae), an important traditional medicinal herb, possesses many biological activities, including anti-inflammatory effects. Though the anti-obesity properties of the crude ethanol extract of A. tsao-ko fruits have been reported, the anti-adipogenic properties of its phytochemical constituents have not been reported. Therefore, in the present study, we isolated the active constituents of A. tsao-ko and investigated their anti-adipogenic effects. The bioassay-guided isolation of the phytochemicals from the ethanol extract of A. tsao-ko fruits identified four bioactive compounds, comprising one fatty acid (1), one sesquiterpene alcohol (2), and two phenolic compounds (3 and 4). Their structures were elucidated by a combination of 1D and/or 2D nuclear magnetic resonance and mass spectrometry. The anti-adipogenic activities of the four compounds evaluated by Oil Red O staining in 3T3-L1 cells revealed that the treatment with the isolated compounds 1 and 3 reduced the lipid accumulation in 3T3-L1 adipocytes more strongly than the compounds 2 and 4, in a dose-dependent manner.
Assessment of carbon stock potential of parkland agroforestry practice: the case of Minjar Shenkora; North Shewa, Ethiopia
Authors: Tsedeke Reta Eshetu , Dawud Seid Muhie , Tafere Solomon Mulu 
Published: January 2021

Abstract
Background
The anthropogenic global climate change has negative impacts on various sectors and communities who particularly rely on rain-fed agriculture. Parkland agroforestry practice can contribute to mitigate and adapt to the forthcoming climate change through carbon sequestration. However, empirical studies on carbon stocks potential of parklands agroforestry practices .

Methodology
By using two-stage stratified random sampling technique, 4 kebeles from two agro ecology were selected and 8 farms/plots/ of 40 m*40 m sample size were selected from each kebele for the vegetation inventory. Tree species-specific allometric equations were used to determine carbon stock potential of parkland agroforestry practice.

Results
The result reveal that, AGC, BGC, SOC and Total Carbon have significant variation (p < 0.05) across kebeles. The mean total carbon stock of Bolo Giorgis, Bolo Slase, Agirat and Korma Agere is 48.87 Mg C ha− 1, 58.21 Mg C ha− 1, 57.81 Mg C ha− 1and 73.71 Mg C ha− 1; respectively. On average, carbon stock of parklands practice in Minjar shenkora was 59.65 Mg C ha− 1.

Conclusions
The parkland agroforestry practice has a large potential to deliver regulating ecosystem services like opportunities to mitigate the impending climate-changing through carbon sequestration and increasing the resilience of the agricultural system at Minjar shenkora woreda. To enhance the multiple ecosystem services of the parkland agroforestry practices in sustainable way: local by-laws should be strengthened to avoid illegal tree cutting and free grazing.
Detecting medication errors associated with the use of beta-lactams in the Russian Pharmacovigilance database
Authors: Kuzmina Anna V. , Asetskaya Irina L. , Zyryanov Sergey K. , Polivanov Vitaliy A. 
Published: January 2021

Abstract
Background
Comprehensive analysis of all available data in spontaneous reports (SRs) can reveal previously unidentified medication errors (MEs).

Methods
To detect MEs, we performed a retrospective analysis of SRs submitted to the Russian pharmacovigilance database in the period from January 01, 2012, to August 01, 2014. This study evaluated SRs of cases where beta-lactam antibiotics were the suspected drug.

Results
A total of 3608 SRs were analyzed. MEswere detected in 1043 reports (28.9% of all cases). The total number of detected errors was 1214. Reporters themselves indicated MEs in 29 SRs. A term denoting an ME was selected in the “Adverse Reactions” section in 18 of these SRs, whereas in the other 11 reports information on the ME was found only in the “Case narrative” section.
MEs were associated with wrong indications in 32.5% of the cases; 61.0% of these cases were viral infections. Various dosing regimen violations constituted 29.7% of MEs. A contraindicated drug was administered in 17.3% of all detected MEs, most commonly to a patient with a history of allergy to the suspected drug or severe hypersensitivity reactions to other drugs of the same group.

Conclusion
Automatic identification of MEs in the pharmacovigilance database is sometimes precluded by the absence of a code for the respective episode in the “Adverse Reactions” section, even when the error was detected by the reporter. The most frequent types of MEs associated with the use of beta-lactams in Russia are the leading risk factors of growing bacterial resistance.
Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances
Authors: Liu Jie , Xie Bin , Mai Binliang , Cai Qiang , He Rujian , Guo Dong , Zhang Zhifeng , Fan Jun , Zhang Weiguang 
Published: January 2021

AbstractRecently, N-nitrosamines have been unexpectedly found in generic sartan products. Herein, we developed a sensitive and stable GC-MS/MS method with multiple reactions monitoring mode for the simultaneous determination of four N-nitrosamines in sartan substances, namely, N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodibutylamine, and N-nitrosodiisopropylamine. The conditions of gas chromatography and mass spectrometry were optimized. The method was validated according to the International Council for Harmonization guidelines in terms of sensitivity, linearity, accuracy, precision, specificity, and stability. The limits of detection of N-nitrosamines in sartan substances ranged from 0.002 to 0.150 ppm, and the corresponding limits of quantification were in the range of 0.008-0.500 ppm, which met the sensitivity requirements for the limits set by the Food and Drug Administration of the United States. The internal standard curve of four N-nitrosamines showed good linearity of regression coefficients over 0.99. The recoveries of N-nitrosamines in selected sartan drugs ranged from 87.68 to 123.76%. The intraday and interday relative standard deviation values were less than 9.15%. Therefore, this proposed method exhibited good sensitivity and precision, high accuracy, and fast analysis speed, which provide a reliable method for quality control of N-nitrosamines in sartan products.
Nomograms based on SUVmax of 18F-FDG PET/CT and clinical parameters for predicting progression-free and overall survival in patients with newly diagnosed extranodal natural killer/T-cell lymphoma
Authors: Li Hongyan , Shao Guozhu , Zhang Yajing , Chen Xiaomin , Du Chengcheng , Wang Kun , Gao Zairong 
Published: January 2021

Abstract
Background
The prognostic value of 18F-FDG PET/CT in extranodal natural killer/T-cell lymphoma (ENKTL) is not well established. We aimed to develop nomograms for individualized estimates of progression-free survival (PFS) and overall survival (OS) in patients with ENKTL using 18F-FDG PET/CT parameters and clinical parameters.

Methods
A total of 171 patients with newly diagnosed ENKTL undergoing 18F-FDG PET/CT scanning were retrospectively analyzed. Nomograms were constructed according to multivariate Cox proportional hazards regression. The predictive and discriminatory capacities of the nomograms were then measured using the concordance index (C-index), calibration plots, and Kaplan-Meier curves. The C-index, the area under receiver operating characteristic (ROC) curve (AUC), and decision curve analysis (DCA) were used to contrast the predictive and discriminatory capacities of the nomograms against with the International Prognostic Index (IPI) and Korean Prognostic Index (KPI).

Results
Multivariate analysis demonstrated that pretreatment SUVmax≥9.5, disease stage II and III-IV, elevated lactate dehydrogenase (LDH), and elevated β2-microglobulin (β2-MG) had the strongest association with unfavorable PFS and OS. In addition, hemoglobin (Hb) < 120 g/L had a tendency to be associated with PFS. Both nomogram models incorporated SUVmax, Ann Arbor stage, LDH, and β2-MG. The PFS nomogram also included Hb. The nomograms showed good prediction accuracies, with the C-indexes for PFS and OS were 0.729 and 0.736, respectively. The calibration plots for 3-year and 5-year PFS/OS reported good consistency between predicted and observed probabilities for survival time. The PFS and OS were significantly different according to tertiles of nomogram scores (p < 0.001). The C-index and AUCs of the nomograms were higher than that of IPI and KPI. Moreover, DCA showed that the predictive accuracy of the nomograms for PFS and OS were both higher than that of IPI and KPI.

Conclusions
This study established nomograms that incorporate pretreatment SUVmax and clinical parameters, which could be effective tools for individualized prognostication of both PFS and OS in patients with newly diagnosed ENKTL.
A graphene film interlayer for enhanced electrical conductivity in a carbon-fibre/PEEK composite
Authors: Leow Christopher , Kreider Peter B. , Notthoff Christian , Kluth Patrick , Tricoli Antonio , Compston Paul 
Published: January 2021

AbstractCarbon-fibre reinforced composites are seeing increased deployment, especially in the aerospace industry, and the next-generation of these materials will need to meet demanding performance requirements beyond just specific strength. The incorporation of nanomaterials such as graphene into composites has great potential for enhancing electrical, thermal, and mechanical properties, which could then enable new capabilities such as built-in lightning strike protection and electromagnetic shielding. One major challenge is successful integration of nanomaterials into the composite during the manufacturing process especially for thermoplastic based composites. This work explores the spray deposition of exfoliated graphene in liquid suspensions for the nano-enhancement of electrical properties in carbon-fibre reinforced polyether ether keytone (PEEK) composites. Developed thin films were smooth with RMS roughness of 1.06 μm on Si substrates and RMS roughness of 1.27 μm on CF-PEEK tapes. The addition of 1.3 wt% graphene into the interlayers of CF-PEEK composites resulted in bulk electrical conductivity enhancement both in plane and through thickness of ~ 1100% and 67.5% respectively. This approach allows for pre-consolidation introduction of high-performance nanomaterials directly to thermoplastic prepregs which could open simple pathways for the in-situ manufacturing of carbon-fibre reinforced polymer nanocomposites.
Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study
Authors: dos Santos Alexandre Moura , Misse Rafael Giovani , Borges Isabela Bruna Pires , Gualano Bruno , de Souza Alexandre Wagner Silva , Takayama Liliam , Pereira Rosa Maria R. , Shinjo Samuel Katsuyuki 
Published: January 2021

Abstract
Background
Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationships with disease status and comorbidities among patients with TAK.

Methods
A multicenter cross-sectional study was conducted between 2019 and 2020, in which 20 adult women with TAK were compared with 16 healthy controls matched by gender, age, and body mass index. The following parameters were analyzed: aerobic capacity by cardiopulmonary test; muscle function by timed-stands test, timed up-and-go test, and handgrip test; muscle strength by one-repetition maximum test and handgrip test; body composition by densitometry; physical activity and metabolic equivalent by IPAQ, quality of life by HAQ and SF-36; disease activity by ITAS2010 and NIH score; and presence of comorbidities.

Results
Patients with TAK had a mean age of 41.5 (38.0–46.3) years, disease duration of 16.0 (9.5–20.0) years, and a mean BMI of 27.7±4.5 kg/m2. Three out of the 20 patients with TAK had active disease. Regarding comorbidities, 16 patients had systemic arterial hypertension, 11 had dyslipidemia, and two had type 2 diabetes mellitus, while the control group had no comorbidities. TAK had a significant reduction in aerobic capacity (absolute and relative VO2 peak), muscle strength in the lower limbs, increased visceral adipose tissue, waist-to-hip ratio, reduced walking capacity, decreased weekly metabolic equivalent, and quality of life (P< 0.05) as compared to controls. However, there were no correlations between these MCRFs parameters and disease activity.

Conclusions
TAK show impairment in MCRFs; therefore, strategies able to improve MCRF should be considered in this disease.
Prevalence, demographics, and clinical characteristics of Latin American patients with spondyloarthritis
Authors: Citera Gustavo , Bautista-Molano Wilson , Peláez-Ballestas Ingris , Azevedo Valderilio F. , Perich Risto A. , Méndez-Rodríguez José A. , Cutri Mariel S. , Borlenghi Cecilia E. 
Published: January 2021

AbstractLarge epidemiologic and clinical estimates of spondyloarthritis (SpA) in Latin America are not available. In this narrative review, our goal was to descriptively summarize the prevalence and features of SpA in Latin America, based on available small studies. A review of peer-reviewed literature identified 41 relevant publications. Of these, 11 (mostly based on Mexican data) estimated the prevalence of SpA and its subtypes, which varied from 0.28 to 0.9% (SpA), 0.02 to 0.8% (ankylosing spondylitis), 0.2 to 0.9% (axial SpA), and 0.004 to 0.08% (psoriatic arthritis). Demographic and/or clinical characteristics were reported in 31 of the 41 publications, deriving data from 3 multinational studies, as well as individual studies from Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, Peru, Uruguay, and Venezuela. Data relating to treatment, disease manifestations (articular and extra-articular), and comorbidities were summarized across the countries. Available data suggest that there is a variability in prevalence, manifestations, and comorbidities of SpA across Latin America. Basic epidemiologic and clinical data are required from several countries not currently represented. Data relating to current treatment approaches, patient outcomes, and socioeconomic impact within this large geographic region are also needed.
An accurate frequency-domain model of water interaction with cylinders of arbitrary shape during earthquakes
Authors: Zhao Mi , Wang Xiaojing , Wang Piguang , Zhang Chao , Du Xiuli 
Published: January 2021

AbstractAn accurate frequency domain model is proposed to analyze the seismic response of uniform vertical cylinders with arbitrary cross section surrounded by water. According to the boundary conditions and using the variables separation method, the vertical modes of the hydrodynamic pressure are firstly obtained. Secondly, the three-dimensional wave equation can be simplified to a two-dimensional Helmholtz equation. Introducing the scaled boundary coordinate, a scaled boundary finite element (SBFE) equation which is a linear non-homogeneous second-order ordinary equation is derived by weighted residual method. The dynamic-stiffness matrix equation for the problem is furtherly derived. The continued fraction is acted as the solution of the dynamic-stiffness matrix for cylinder dynamic interaction of cylinder with infinite water. The coefficient matrices of the continued fraction are derived recursively from the SBFE equation of dynamic-stiffness. The accuracy of the present method is verified by comparing the hydrodynamic force on circular, elliptical and rectangle cylinders with the analytical or numerical solutions. Finally, the proposed model is used to analyze the natural frequency and seismic response of cylinders.
Atrial Fibrillation in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation
Authors: Chang Ellen K. , Chanson Dayana , Teh Jennifer Berano , Iukuridze Aleksi , Peng Kelly , Forman Stephen J. , Nakamura Ryotaro , Wong F. Lennie , Cai LiYing , Armenian Saro H. 
Published: January 2021

PURPOSE To examine the incidence and risk factors for de novo atrial fibrillation (AF) after allogeneic hematopoietic cell transplantation (HCT) and to describe the impact of AF on HCT-related outcomes. METHODS A retrospective cohort study design was used to examine AF and associated outcomes in 487 patients who underwent allogeneic HCT from 2014 to 2016 and to characterize patient- and HCT-related risk factors. A nested case-control study design was used to describe the association between pre-HCT echocardiographic measures and future AF events. RESULTS The median age at HCT was 52.4 years (18.1-78.6); the median time to AF was 117.5 days (4.0-1,405.0). The 5-year cumulative incidence of AF was 10.6%. Older (≥ 50 years) age (hazard ratio [HR], 2.76; 95% CI, 1.37 to 5.58), HLA-unrelated donor (HR, 2.20; 95% CI, 1.18 to 4.12), dyslipidemia (HR, 2.40; 95% CI, 1.23 to 4.68), and pre-HCT prolonged QTc interval (HR, 2.55; 95% CI, 1.38 to 4.72) were independent risk factors for AF. Despite having comparable left ventricular systolic function, patients who developed AF were significantly more likely to have lower left atrial ejection fraction, left atrial reservoir function, and elevated tricuspid regurgitant jet velocity prior to HCT, compared with patients who did not. The incidence rate of stroke after AF was 143 per 1,000 person-years. In adjusted analyses, AF was associated with a 12.8-fold (HR, 12.76; 95% CI, 8.76 to 18.57) risk of all-cause mortality and 15.8-fold (HR, 15.78; 95% CI, 8.70 to 28.62) risk of nonrelapse mortality. CONCLUSION The burden of AF after allogeneic HCT population is substantial, and the development of AF is associated with poor survival. We identified important associations between patient demographics, pre-HCT cardiac parameters, HCT-related exposures, and risk of AF, setting the stage for targeted prevention strategies during and after HCT.
Provider-Level Variation in Treatment Planning of Radiation Oncology Procedures in the United States
Authors: Valle Luca F. , Chu Fang-I. , Yoon Stephanie M. , Kundu Palak , Venkat Puja , Gilchrist Travis , Steinberg Michael L. , Raldow Ann C. 
Published: January 2021

PURPOSE:Variation in the use of radiation oncology procedures and technologies is poorly characterized. We sought to identify associations between the treatment planning codes used to bill for radiotherapy procedures and the demographic characteristics of the radiation oncologists submitting them.METHODS:The Physician and Other Supplier Public Use File was linked to the Physician Compare database by using the physician National Provider Identifier for the year 2016. Analysis was stratified by practice setting, considering both the freestanding non–facility-based (NFB) setting and the facility-based (FB) setting. Multivariable logistic regression was used to determine provider characteristics (gender, practice rurality, and years since graduation) that predicted for the use of 3D-conformal RT (3DCRT) planning, intensity-modulated RT (IMRT) planning, and brachytherapy planning in the Medicare population.RESULTS:Three thousand twenty-nine physicians were linked for analysis. In both the FB and NFB settings together, male gender predicted for decreased likelihood of 3DCRT planning (OR, 0.70, 95% CI, 0.62 to 0.80, P < .001) and increased likelihood of IMRT planning (OR, 1.35, 95% CI, 1.19 to 1.54, P < .001). Brachytherapy planning was also more likely with increasing years since medical school graduation (OR, 1.03, 95% CI, 1.01 to 1.04, P < .001) in the combined FB and NFB settings. These significant associations persisted when examining the NFB and FB settings individually. In both settings overall, brachytherapy planning was more likely in male providers (OR, 1.75, 95% CI, 1.10 to 2.76, P = .02) and also more likely for providers practicing in metropolitan regions compared with those practicing in rural areas (OR, 3.01, 95% CI, 1.23 to 7.39, P = .02).CONCLUSION:Male gender predicts for utilization of IMRT planning, whereas female gender predicts for utilization of 3DCRT planning. Future research is warranted to better understand the role that provider gender and rurality play in the selection of radiation planning techniques for Medicare patients.