bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression, anxiety, stress and their associated factors among Ethiopian University students during an early stage of COVID-19 pandemic: An online-based cross-sectional survey
Authors: Simegn Wudneh , Dagnew Baye , Yeshaw Yigizie , Yitayih Sewbesew , Woldegerima Birhanemeskel , Dagne Henok 
Published: May 2021

Background
The occurrence of the Coronavirus Disease 2019 (COVID-19) affects the mental health situation of almost everyone, including University students who spent most of their time at home due to the closure of the Universities. Therefore, this study aimed at assessing depression, anxiety, stress and identifying their associated factors among university students in Ethiopia during the early stage of the COVID-19 pandemic.

Methods
We invited students to complete an online survey using Google forms comprising consent, socio-demographic characteristics, and the standard validated depression, anxiety, and stress scale (DASS-21) questionnaire. After completion of the survey from June 30 to July 30, 2020, we exported the data into SPSS 22. Both descriptive and analytical statistics were computed. Associated factors were identified using binary logistic regression and variables with a p-value <0.05 were declared as statistically significant factors with the outcome variables.

Results
A total of 423 students completed the online survey. The prevalence of depression, anxiety, and stress in this study was 46.3%, 52%, and 28.6%, respectively. In the multivariable model, female sex, poor self-efficacy to prevent COVID-19, those who do not read any material about COVID-19 prevention, lack of access to reading materials about their profession, and lack of access to uninterrupted internet access were significantly associated with depression. Female sex, lower ages, students with non-health-related departments, those who do not think that COVID-19 is preventable, and those who do not read any materials about COVID-19 prevention were significantly associated with anxiety. Whereas, being female, students attending 1st and 2nd years, those who do not think that COVID-19 is preventable, presence of confirmed COVID-19 patient at the town they are living in, and lack of access to reading materials about their profession were significantly associated with stress.

Conclusions
Depression, anxiety, and stress level among University students calls for addressing these problems by controlling the modifiable factors identified and promoting psychological wellbeing of students.
Effectiveness and trend forecasting of tuberculosis diagnosis after the introduction of GeneXpert in a city in south-eastern Brazil
Authors: Berra Thaís Zamboni , Gomes Dulce , Ramos Antônio Carlos Vieira , Alves Yan Mathias , Bruce Alexandre Tadashi Inomata , Arroyo Luiz Henrique , Santos Felipe Lima dos , Souza Ludmilla Leideanne Limirio , Crispim Juliane de Almeida , Arcêncio Ricardo Alexandre 
Published: May 2021

BackgroundTo evaluate the effectiveness of a rapid molecular test for the detection of tuberculosis (TB) and to predict the rates of disease in a municipality of Brazil where TB is endemic.MethodsAn ecological study was carried out in Ribeirão Preto-SP on a population of TB cases notified between 2006 and 2017. Monthly TB incidence rates and the average monthly percentage change (AMPC) were calculated. In order to identify changes in the series, the breakpoint technique was performed; the rates were modelled and predictions of the incidence of TB until 2025 were made.ResultsAMPC showed a fall of 0.69% per month in TB and human immunodeficiency virus (TB-HIV) co-infection, a fall of 0.01% per month in general and lung TB and a fall of 0.33% per month in extrapulmonary TB. With the breakpoint technique, general and pulmonary TB changed in structure in late 2007, and extrapulmonary TB and TB-HIV co-infection changed in structure after 2014, which is considered the cut-off point. The IMA(3) models were adjusted for general and pulmonary TB and TB-HIV co-infection, and the AR(5) models for extrapulmonary TB, and predictions were performed.ConclusionsThe rapid molecular test for TB is the method currently recommended by the WHO for the diagnosis of the disease and its main advantage is to provide faster, more accurate results and to already check for drug resistance. It is necessary that professionals encourage the use of this technology in order to optimize the diagnosis so that the treatment begins as quickly as possible and in an effective way. Only by uniting professionals from all areas with health policies aimed at early case identification and rapid treatment initiation it is possible to break the chain of TB transmission so that its rates decrease and the goals proposed by the WHO are achieved.
Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication
Authors: Artman Chad , Brumfield Kyle D. , Khanna Sahil , Goepp Julius 
Published: May 2021

BackgroundThe global pandemic of Coronavirus infectious disease 2019 (COVID-19), caused by SARS-CoV-2, has plunged the world into both social and economic disarray, with vaccines still emerging and a continued paucity of personal protective equipment; the pandemic has also highlighted the potential for rapid emergence of aggressive respiratory pathogens and the need for preparedness. Avian immunoglobulins (IgY) have been previously shown in animal models to protect against new infection and mitigate established infection when applied intranasally. We carried out a proof-of-concept study to address the feasibility of using such antibodies as mucosally-applied prophylaxis against SARS-CoV-2.MethodsHens were immunized with recombinant S1 spike glycoprotein of the virus, and the resulting IgY was evaluated for binding specificity, inhibition of glycoprotein binding to angiotensin converting enzyme-2 (ACE2) protein (the requisite binding site for the virus), and inhibition of viral replication in Vero cell culture.ResultsTiters of anti-S1 glycoprotein IgY were evident in yolks at 14 days post-immunization, peaking at 21 days, and at peak concentrations of 16.8 mg/ml. IgY showed strong and significant inhibition of S1/ACE2 binding interactions, and significantly inhibited viral replication at a concentration of 16.8 mg/ml. Four weeks’ collection from eggs of two hens produced a total of 1.55 grams of IgY.ConclusionsIn this proof-of-concept study we showed that avian immunoglobulins (IgY) raised against a key virulence factor of the SARS-CoV-2 virus successfully inhibited the critical initial adhesion of viral spike glycoproteins to human ACE2 protein receptors and inhibited viral replicationin vitro, in a short period using only two laying hens. We conclude that production of large amounts of IgY inhibiting viral binding and replication of SARS-CoV-2 is feasible, and that incorporation of this or similar material into an intranasal spray and/or other mucosal protecting products may be effective at reducing infection and spread of COVID-19.
Building a community of practice through social media using the hashtag #neoEBM
Authors: Keir Amy , Bamat Nicolas , Hennebry Bron , King Brian , Patel Ravi , Wright Clyde , Scrivens Alexandra , ElKhateeb Omar , Mitra Souvik , Roland Damian 
Published: May 2021

Objectives
Social media use is associated with developing communities of practice that promote the rapid exchange of information across traditional institutional and geographical boundaries faster than previously possible. We aimed to describe and share our experience using #neoEBM (Neonatal Evidence Based Medicine) hashtag to organise and build a digital community of neonatal care practice.

Materials and methods
Analysis of #neoEBM Twitter data in the Symplur Signals database between 1 May 2018 to 9 January 2021. Data on tweets containing the #neoEBM hashtag were analysed using online analytical tools, including the total number of tweets and user engagement.

Results
Since its registration, a total of 3 228 distinct individual Twitter users used the hashtag with 23 939 tweets and 37 259 710 impressions generated. The two days with the greatest number of tweets containing #neoEBM were 8 May 2018 (n = 218) and 28 April 2019 (n = 340), coinciding with the annual Pediatric Academic Societies meeting. The majority of Twitter users made one tweet using #neoEBM (n = 1078), followed by two tweets (n = 411) and more than 10 tweets (n = 347). The number of individual impressions (views) of tweets containing #neoEBM was 37 259 710. Of the 23 939 tweets using #neoEBM, 17 817 (74%) were retweeted (shared), 15 643 (65%) included at least one link and 1 196 (5%) had at least one reply. As #neoEBM users increased over time, so did tweets containing #neoEBM, with each additional user of the hashtag associated with a mean increase in 7.8 (95% CI 7.7–8.0) tweets containing #neoEBM.

Conclusion
Our findings support the observation that the #neoEBM community possesses many of the characteristics of a community of practice, and it may be an effective tool to disseminate research findings. By sharing our experiences, we hope to encourage others to engage with or build online digital communities of practice to share knowledge and build collaborative networks across disciplines, institutions and countries.
Disparities in behavioral health and experience of violence between cisgender and transgender Thai adolescents
Authors: Wichaidit Wit , Assanangkornchai Sawitri , Chongsuvivatwong Virasakdi 
Published: May 2021

BackgroundThe term "transgender" refers to an individual whose gender identity is different from their sex assigned at birth, whereas the term "cisgender" refers to an individual whose gender identity is the same as their sex assigned at birth. In Thailand, studies on health outcomes and quality of life of Thai transgender youths have not included assessments from nationally-representative samples. The objective of this study is to assess the extent that behavioral health outcomes and exposure to violence varied by gender among respondents of the National School Survey on Alcohol Consumption, Substance Use and Other Health-Risk Behaviors.MethodsWe used data from a nationally-representative self-administered survey of secondary school students in years 7, 9 and 11 and classified participants as cisgender boys, cisgender girls, transgender boys, and transgender girls. Participants also answered questions on depressive experience, suicidality, sexual behaviors, alcohol and tobacco use, drug use, and past-year experience of violence. We analyzed data using descriptive statistics and modified multivariate Poisson regression with adjustment for sampling weights to calculate adjusted prevalence ratios (APR) with 95% confidence intervals.ResultsA total of 31,898 respondents (82.8% of those who returned complete and valid questionnaires) answered questions on sex and gender identity and were included in the analyses (n = 31,898 respondents), approximately 2.5% of whom identified as transgender. Transgender boys had a higher prevalence suicidal ideation than cisgender boys (APR = 2.97; 95% CI = 1.89, 4.67) and cisgender girls (APR = 2.29; 95% CI = 1.55, 3.40). Transgender girls were less likely than cisgender boys and girls to be ever drinkers, while transgender boys were more likely than cisgender boys and girls to be ever drinkers. Transgender girls had higher past-year exposure to sexual violence than cisgender boys (APR = 2.74; 95% CI = 1.52, 4.95) and cisgender girls (APR = 4.93; 95% CI = 2.52, 9.67).ConclusionWe found disparities in behavioral health and experience of violence between transgender and cisgender adolescents in Thailand. The findings highlighted the need for program managers and policy makers to consider expanding local efforts to address health gaps in the LGBTQ community to also include school-going youth population.
Focused ultrasound of the caudal vena cava in dogs with cavitary effusions or congestive heart failure: A prospective, observational study
Authors: Chou Yen-Yu , Ward Jessica L. , Barron Lara Z. , Murphy Shane D. , Tropf Melissa A. , Lisciandro Gregory R. , Yuan Lingnan , Mochel Jonathan P. , DeFrancesco Teresa C. 
Published: May 2021

Introduction
Ultrasonographic indices of the inferior vena cava are useful for predicting right heart filling pressures in people.

Objectives
To determine whether ultrasonographic indices of caudal vena cava (CVC) differ between dogs with right-sided CHF (R-CHF), left-sided CHF (L-CHF), and noncardiac causes of cavitary effusion (NC).

Materials and methods
113 dogs diagnosed with R-CHF (n = 51), L-CHF (30), or NC effusion (32) were enrolled. Seventeen of the R-CHF dogs had pericardial effusion and tamponade. Focused ultrasound was performed prospectively to obtain 2-dimensional and M-mode subxiphoid measures of CVC maximal and minimal size (CVCmax and CVCmin), CVCmax indexed to aortic dimension (CVC:Ao), and CVC collapsibility index (CVC-CI). Variables were compared between study groups using Kruskal-Wallis and Dunn’s-Bonferroni testing, and receiver operating characteristics curves were used to assess sensitivity and specificity.

Results
All sonographic CVC indices were significantly different between R-CHF and NC dogs (P < 0.001). Variables demonstrating the highest diagnostic accuracy for discriminating R-CHF versus NC were CVC-CI <33% in 2D (91% sensitive and 96% specific) and presence of hepatic venous distension (84% sensitive and 90% specific). L-CHF dogs had higher CVC:Ao and lower CVC-CI compared to NC dogs (P = 0.016 and P = 0.043 in 2D, respectively) but increased CVC-CI compared to the R-CHF group (P < 0.001).

Conclusions
Ultrasonographic indices of CVC size and collapsibility differed between dogs with R-CHF compared to NC causes of cavitary effusions. Dogs with L-CHF have CVC measurements intermediate between R-CHF and NC dogs.
PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection
Authors: Murphy Sean C. , Deye Gregory A. , Sim B. Kim Lee , Galbiati Shirley , Kennedy Jessie K. , Cohen Kristen W. , Chakravarty Sumana , KC Natasha , Abebe Yonas , James Eric R. , Kublin James G. , Hoffman Stephen L. , Richie Thomas L. , Jackson Lisa A. 
Published: May 2021

PfSPZ-CVac combines ‘PfSPZ Challenge’, which consists of infectious Plasmodium falciparum sporozoites (PfSPZ), with concurrent antimalarial chemoprophylaxis. In a previously-published PfSPZ-CVac study, three doses of 5.12x104 PfSPZ-CVac given 28 days apart had 100% vaccine efficacy (VE) against controlled human malaria infection (CHMI) 10 weeks after the last immunization, while the same dose given as three injections five days apart had 63% VE. Here, we conducted a dose escalation trial of similarly condensed schedules. Of the groups proceeding to CHMI, the first study group received three direct venous inoculations (DVIs) of a dose of 5.12x104 PfSPZ-CVac seven days apart and the next full dose group received three DVIs of a higher dose of 1.024x105 PfSPZ-CVac five days apart. CHMI (3.2x103 PfSPZ Challenge) was performed by DVI 10 weeks after the last vaccination. In both CHMI groups, transient parasitemia occurred starting seven days after each vaccination. For the seven-day interval group, the second and third vaccinations were therefore administered coincident with parasitemia from the prior vaccination. Parasitemia was associated with systemic symptoms which were severe in 25% of subjects. VE in the seven-day group was 0% (7/7 infected) and in the higher-dose, five-day group was 75% (2/8 infected). Thus, the same dose of PfSPZ-CVac previously associated with 63% VE when given on a five-day schedule in the prior study had zero VE here when given on a seven-day schedule, while a double dose given on a five-day schedule here achieved 75% VE. The relative contributions of the five-day schedule and/or the higher dose to improved VE warrant further investigation. It is notable that administration of PfSPZ-CVac on a schedule where vaccine administration coincided with blood-stage parasitemia was associated with an absence of sterile protective immunity.
Clinical trials registration: NCT02773979.
Énmegjelenítési stratégiák egyetemisták körében
Authors: Szabó Éva 
Published: May 2021

Dolgozatomban egy pilot kutatás részeredményeit ismertetem, amelyben egyetemisták énmegjelenítési/benyomáskeltési stratégiáit vizsgálom. A szociálpszichológiai megközelítések habár eltérő módon definiálják az énmegjelenítést/benyomáskeltést a tudatosság tekintetében, mégis egyöntetűen stratégiákat rendelnek a jelenséghez (Goffman 1959; Schlenker 1980; Jones–Pittman 1982; Leary–Kowalski 1990; Leary 1995).A pilot kutatás elsődleges célja az, hogy a szociálpszichológiai és a pragmatikai megközelítéseket ötvözve létrehozzon egy olyan tesztet, amely alkalmas az énmegjelenítés/benyomáskeltés vizsgálatára. A dolgozatban a magyar anyanyelvű egyetemi hallgatók számára létrehozott, az énmegjelenítési stratégiákat vizsgáló nyílt végű diskurzuskiegészítéses teszt adatgyűjtési módszert ismertetem, illetve annak metodológiai problémáit járom körül. A pilot teszt eredményei alapján megállapítható, hogy egy szituációban nem megjósolhatóak a stratégiák, hanem a különböző társas interakciók esetében vannak kevésbé vagy inkább preferált metódusok, melyeket meghatároznak a benyomáskeltés mögött meghúzódó lehetséges motivációk, az arculatfenyegetettség mértéke, a szociológiai és szociokulturális változók.
The European Biological Variation Study (EuBIVAS): a summary report
Authors: Carobene Anna , Aarsand Aasne K. , Bartlett William A. , Coskun Abdurrahman , Diaz-Garzon Jorge , Fernandez-Calle Pilar , Guerra Elena , Jonker Niels , Locatelli Massimo , Plebani Mario , Sandberg Sverre , Ceriotti Ferruccio 
Published: May 2021

Abstract
Biological variation (BV) data have many important applications in laboratory medicine. Concerns about quality of published BV data led the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) 1st Strategic Conference to indicate need for new studies to generate BV estimates of required quality. In response, the EFLM Working Group on BV delivered the multicenter European Biological Variation Study (EuBIVAS). This review summarises the EuBIVAS and its outcomes. Serum/plasma samples were taken from 91 ostensibly healthy individuals for 10 consecutive weeks at 6 European centres. Analysis was performed by Siemens ADVIA 2400 (clinical chemistry), Cobas Roche 8000, c702 and e801 (proteins and tumor markers/hormones respectively), ACL Top 750 (coagulation parameters), and IDS iSYS or DiaSorin Liaison (bone biomarkers). A strict preanalytical and analytical protocol was applied. To determine BV estimates with 95% CI, CV-ANOVA after analysis of outliers, homogeneity and trend analysis or a Bayesian model was applied. EuBIVAS has so far delivered BV estimates for 80 different measurands. Estimates for 10 measurands (non-HDL cholesterol, S100-β protein, neuron-specific enolase, soluble transferrin receptor, intact fibroblast growth-factor-23, uncarboxylated-unphosphorylated matrix-Gla protein, human epididymis protein-4, free, conjugated and %free prostate-specific antigen), prior to EuBIVAS, have not been available. BV data for creatinine and troponin I were obtained using two analytical methods in each case. The EuBIVAS has delivered high-quality BV data for a wide range of measurands. The BV estimates are for many measurands lower than those previously reported, having an impact on the derived analytical performance specifications and reference change values.
CEOs’ Joy of Working for the Family Firm: The Role of Psychological Ownership and Stewardship Behavior
Authors: Henssen Bart , Koiranen Matti 
Published: May 2021

AbstractIn this article, we examine the factors which lead to CEOs’ joy of working for the family firm, as it is expected to contribute to their willingness to invest in its perpetuation and success. We focus on three such factors: CEOs’ collective psychological ownership, their individual psychological ownership, and CEOs’ stewardship behavior. We find that on the one hand, the relationship between CEOs’ collective psychological ownership and their joy of working for the family business is mediated by their stewardship behavior, and on the other hand, stewardship behavior mediates the relationship between CEOs’ individual psychological ownership and their joy of work. We make valuable contributions to psychological ownership literature, to stewardship literature, and to the literature on joy and joy at work.
Oenological property analysis of selected Hanseniaspora uvarum isolated from Rosa roxburghii Tratt
Authors: Liu Xiaozhu , Li Yinfeng , Zhao Hubing , Yu Zhihai , Huang Mingzheng 
Published: May 2021

Abstract
Oenological yeasts play a crucial role in the winemaking process by converting sugar into ethanol, carbon dioxide and flavor substances that contribute to the wine aroma profile. Eighty strains of yeast were isolated from Rosa roxburghii Tratt. Three of the indigenous yeast strains (numbered as C26, C31 and F110) were selected based on having the strongest fruity-aroma producing ability to further evaluate theirs oenological properties, and they were identified as Hanseniaspora uvarum based on morphological and molecular analyses. Strains tolerance results showed that the selected strains have glucose, citric acid and sulfur dioxide tolerances that are comparable to commercial Saccharomyces cerevisiae X16, but they are ethanol sensitive. Additionally, the H. uvarum strains had similar β-glucosidase production abilities to the control, but they do not produce hydrogen sulfide. Moreover, the selected H. uvarum strains reduced the acidity and increased the volatile aroma richness and complexity of R. roxburghii wine during laboratory-scale fermentation. Thus, the selected H. uvarum strains (C26, C31 and F110) show potential in the production of unique R. roxburghii wine.
The language division of labour across occupations: an introduction
Authors: Alarcón Alarcón Amado 
Published: May 2021

Abstract
This special issue contributes to understanding the role of language division of labour across occupations. The articles contribute to sociological understanding and critical dialogue with a human capital perspective in the context of the information society, where language has a central role in production processes. Since information as raw material and product is linguistically encoded, language occupies a central role in new forms of division of labour. The main question in this introduction and subsequent articles is to what extent social changes of information centrality at the production level reproduce or create new social inequalities observable through the lens of language division of labour within occupations. Although progress has been made in knowledge about competencies in the information and digital environment, little is known about specific linguistic needs across occupational classifications. Given the widespread use of alphabetization, literacy is today taken as a sine qua non for entering labour markets, instead of a stratifier across occupations and social structure. Nevertheless, in this special issue authors show that language of origin, second-language knowledge, and other literacies, such as communicative skills, become key stratifier factors. This is observable at the territorial level, types of literacies, as well as in specific and sophisticated language professions.