bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Care-coordination Approach to Learning Lupus Self-Management: a patient navigator intervention for systemic lupus inpatients
Authors: White Ashley A , Ba Aissatou , Faith Trevor Daniel , Ramakrishnan Viswanathan , Dismuke-Greer Clara L , Oates Jim C , Williams Edith Marie 
Published: May 2021

ObjectiveThe Care-coordination Approach to Learning Lupus Self-Management (CALLS) study was designed to improve SLE disease self-management. This study aims to assess the benefits of the intervention compared with existing lupus care.MethodsParticipants were randomly assigned to participate in 12-weekly phone sessions with the patient navigator that included structured educational content, care coordination and patient-centred support services, or a usual care control condition. Validated measures of health literacy, self-efficacy, patient activation and disease activity were collected. We used least squares means and linear mixed-effects regression models for each outcome variable to assess the changes in outcome, from baseline to postintervention and to estimate the difference in these changes between the intervention and control group.ResultsThirty participants were enrolled and 14 were randomised to the treatment group. For perceived lupus self-efficacy, there was a significant increase in mean score for the intervention group, but not for the control group. With regard to disease activity, the experimental group experienced a slight decrease in mean flare score in the previous 3 months, whereas the control group experienced a slight increase, but this finding did not reach statistical significance. Trends were similar in self-reported global disease activity, but none of the findings were significant. Health literacy and patient activation measure scores remained largely unchanged throughout the study for the two groups.ConclusionThese findings suggest that the CALLS intervention may work to improve aspects of SLE disease self-management. Future research will be needed to validate these findings long-term.Trial registration numberNCT04400240.
Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy
Authors: Mereuta Oana Madalina , Abbasi Mehdi , Fitzgerald Seán , Dai Daying , Kadirvel Ram , Hanel Ricardo A , Yoo Albert J , Almekhlafi Mohammed A , Layton Kennith F , Delgado Almandoz Josser E , Kvamme Peter , Mendes Pereira Vitor , Jahromi Babak S , Nogueira Raul G , Gounis Matthew J , Patel Biraj , Aghaebrahim Amin , Sauvageau Eric , Bhuva Parita , Soomro Jazba , Demchuk Andrew M , Thacker Ike C , Kayan Yasha , Copelan Alexander , Nazari Pouya , Cantrell Donald Robert , Haussen Diogo C , Al-Bayati Alhamza R , Mohammaden Mahmoud , Pisani Leonardo , Rodrigues Gabriel Martins , Puri Ajit S , Entwistle John , Meves Alexander , Arturo Larco Jorge L , Savastano Luis , Cloft Harry J , Kallmes David F , Doyle Karen M , Brinjikji Waleed 
Published: May 2021

BackgroundSeveral animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following MT are difficult to determine.ObjectiveTo investigate the occurrence of VWI during MT by histological and immunohistochemical evaluation of AIS clots.MethodsAs part of the multicenter STRIP registry, 277 clots from 237 patients were analyzed using Martius Scarlett Blue stain and immunohistochemistry for CD34 (endothelial cells) and smooth muscle actin (smooth muscle cells).ResultsMT devices used were aspiration catheters (100 cases), stentriever (101 cases), and both (36 cases). VWI was found in 33/277 clots (12%). There was no significant correlation between VWI and MT device. The degree of damage varied from grade I (mild intimal damage, 24 clots), to grade II (relevant intimal and subintimal damage, 3 clots), and III (severe injury, 6 clots). VWI clots contained significantly more erythrocytes (p=0.006*) and less platelets/other (p=0.005*) than non-VWI clots suggesting soft thrombus material.Thrombolysis correlated with a lower rate of VWI (p=0.04*). VWI cases showed a significantly higher number of passes (2 [1–4] vs 1 [1–3], p=0.028*) and poorer recanalization outcome (p=0.01*) than cases without VWI.ConclusionsHistological markers of VWI were present in 12% of AIS thrombi, suggesting that VWI might be related to MT. VWI was associated with soft thrombus consistency, higher number of passes and poorer revascularization outcome. There was no significant correlation between VWI and MT device.
Lung function in children with cystic fibrosis in the USA and UK: a comparative longitudinal analysis of national registry data
Authors: Schlüter Daniela K , Ostrenga Josh S , Carr Siobhán B , Fink Aliza K , Faro Albert , Szczesniak Rhonda D , Keogh Ruth H , Charman Susan C , Marshall Bruce C , Goss Christopher H , Taylor-Robinson David 
Published: May 2021

RationaleA previous analysis found significantly higher lung function in the US paediatric cystic fibrosis (CF) population compared with the UK with this difference apparently decreasing in adolescence and adulthood. However, the cross-sectional nature of the study makes it hard to interpret these results.ObjectivesTo compare longitudinal trajectories of lung function in children with CF between the USA and UK and to explore reasons for any differences.MethodsWe used mixed effects regression analysis to model lung function trajectories in the study populations. Using descriptive statistics, we compared early growth and nutrition (height, weight, body mass index), infections (Pseudomonas aeruginosa, Staphylococcus aureus) and treatments (rhDnase, hypertonic saline, inhaled antibiotics).ResultsWe included 9463 children from the USA and 3055 children from the UK with homozygous F508del genotype. Lung function was higher in the USA than in the UK when first measured at age six and remained higher throughout childhood. We did not find important differences in early growth and nutrition, or P.aeruginosa infection. Prescription of rhDNase and hypertonic saline was more common in the USA. Inhaled antibiotics were prescribed at similar levels in both countries, but Tobramycin was prescribed more in the USA and colistin in the UK. S. aureus infection was more common in the USA than the UK.ConclusionsChildren with CF and homozygous F508del genotype in the USA had better lung function than UK children. These differences do not appear to be explained by early growth or nutrition, but differences in the use of early treatments need further investigation.
The tundra phenology database: more than two decades of tundra phenology responses to climate change
Authors: Prevéy Janet S. , Elmendorf Sarah Claire , Bjorkman Anne , Alatalo Juha M. , Ashton Isabel , Assmann Jakob J. , Björk Robert G. , Björkman Mats P. , Cannone Nicoletta , Carbognani Michele , Chisholm Chelsea , Clark Karin , Collins Courtney G. , Cooper Elisabeth J. , Elberling Bo , Frei Esther R. , Henry Gregory R.H. , Hollister Robert D. , Høye Toke Thomas , Jónsdóttir Ingibjörg Svala , Kerby Jeffrey T. , Klanderud Kari , Kopp Christopher , Levesque Esther , Mauritz Marguerite , Molau Ulf , Myers-Smith Isla H. , Natali Susan M. , Oberbauer Steven F. , Panchen Zoe , Petraglia Alessandro , Post Eric , Rixen Christian , Rodenhizer Heidi , Rumpf Sabine B. , Schmidt Niels Martin , Schuur Ted , Semenchuk Philipp , Smith Jane Griffin , Suding Katharine , Totland Ørjan , Troxler Tiffany , Wahren Henrik , Welker Jeffrey M. , Wipf Sonja , Yang Yue 
Published: May 2021

Observations of changes in phenology have provided some of the strongest signals of the effects of climate change on terrestrial ecosystems. The International Tundra Experiment (ITEX), initiated in the early 1990s, established a common protocol to measure plant phenology in tundra study areas across the globe. Today, this valuable collection of phenology measurements depicts the responses of plants at the colder extremes of our planet to experimental and ambient changes in temperature over the past decades. The database contains 150 434 phenology observations of 278 plant species taken at 28 study areas for periods of 1–26 years. Here we describe the full data set to increase the visibility and use of these data in global analyses and to invite phenology data contributions from underrepresented tundra locations. Portions of this tundra phenology database have been used in three recent syntheses, some data sets are expanded, others are from entirely new study areas, and the entirety of these data are now available at the Polar Data Catalogue ( https://doi.org/10.21963/13215 ).
Establishing the first hidden-charm pentaquark with strangeness
Authors: Chen Hua-Xing , Chen Wei , Liu Xiang , Liu Xiao-Hai 
Published: May 2021

AbstractWe study the $$P_{cs}(4459)^0$$

P

cs

(
4459
)

0

recently observed by LHCb using the method of QCD sum rules. Our results support its interpretation as the $${{\bar{D}}}^* \varXi _c$$

D

¯

∗

Ξ
c

hadronic molecular state of either $$J^P=1/2^-$$

J
P

=
1
/

2
-

or $$3/2^-$$

3
/

2
-

. Within the hadronic molecular picture, the three LHCb experiments observing $$P_c$$

P
c

and $$P_{cs}$$

P

cs

states (Aaij et al., Phys Rev Lett 115:072001, 2015; Aaij et al., Phys Rev Lett 122:222001, 2019; Aaij et al., arXiv:2012.10380 [hep-ex], 2012) can be well understood as a whole. This strongly supports the existence of hadronic molecules, whose studies can significantly improve our understanding on the construction of the subatomic world. To verify this picture, we propose to further investigate the $$P_{cs}(4459)^0$$

P

cs

(
4459
)

0

to examine whether it can be separated into two states, and to search for the $${{\bar{D}}} \varXi _c$$

D

¯

Ξ
c

molecular state of $$J^P=1/2^{-}$$

J
P

=
1
/

2
-

.
Measurement of Iris Thickness at Different Regions in Healthy Chinese Adults
Authors: Li Qingchen , Zong Yuan , Wen Huiming , Yu Jian , Zhou Changbo , Jiang Chunhui , Liu Guangxing , Sun Xinghuai 
Published: May 2021

Purpose. To study the variation of iris thicknesses in different regions and explore the possible correlations with age and gender. Methods. Healthy Chinese adults were recruited; the anterior segment of their eyes was imaged by swept-source optical coherence tomography (SS-OCT). The horizontal scan of the right eye was selected, and the thicknesses of both the nasal and temporal irises were measured at 199 evenly spaced points. Results. A total of 233 subjects with an average age of 36.79 ± 10.04 years (range 19 to 62) were included in the final analysis. The mean iris thicknesses of the temporal and nasal sides were 364.79 ± 47.58 μm and 372.44 ± 43.75 μm, respectively. The mean nasal iris thickness was positively correlated with age (β = 0.9 μm/year;

P

= 0.002), but the temporal one was not (β = 0.077 μm/year;

P

= 0.806). At 139 points of the nasal iris and 146 points of the temporal iris, the iris thickness was significantly correlated with age (

P

< 0.05). The thicknesses of the peripheral and pupillary parts were positively correlated with age, while the middle part was negatively correlated with age. No significant difference was observed in the mean iris thickness between genders (temporal: t = 1.597,

P

= 0.112; nasal: t = 1.870,

P

= 0.063), but females had a thicker iris than males at 50 points in the temporal side and 49 points in the nasal side (

P

< 0.05); no point in males was observed to have thicker iris compared to females. Conclusion. Using SS-OCT and the novel method, thicknesses of the iris at different regions were measured. The thicknesses of the peripheral and pupillary irises increase with age, while the thicknesses of the middle part decrease.
The MNK1/2–eIF4E Axis Supports Immune Suppression and Metastasis in Postpartum Breast Cancer
Authors: Guo Qianyu , Bartish Margarita , Gonçalves Christophe , Huang Fan , Smith-Voudouris Julian , Krisna Sai Sakktee , Preston Samuel E.J. , Emond Audrey , Li Vivian Z. , Duerr Claudia U. , Gui Yirui , Cleret-Buhot Aurélie , Thebault Pamela , Lefrère Hanne , Lenaerts Liesbeth , Plourde Dany , Su Jie , Mindt Barbara C. , Hewgill Shannon A. , Cotechini Tiziana , Hindmarch Charles C.T. , Yang William , Khoury Elie , Zhan Yao , Narykina Valeria , Wei Yuhong , Floris Giuseppe , Basik Mark , Amant Frédéric , Quail Daniela F. , Lapointe Réjean , Fritz Jörg H. , del Rincon Sonia V. , Miller Wilson H. 
Published: May 2021

Abstract

Breast cancer diagnosed within 10 years following childbirth is defined as postpartum breast cancer (PPBC) and is highly metastatic. Interactions between immune cells and other stromal cells within the involuting mammary gland are fundamental in facilitating an aggressive tumor phenotype. The MNK1/2–eIF4E axis promotes translation of prometastatic mRNAs in tumor cells, but its role in modulating the function of nontumor cells in the PPBC microenvironment has not been explored. Here, we used a combination of in vivo PPBC models and in vitro assays to study the effects of inactivation of the MNK1/2–eIF4E axis on the protumor function of select cells of the tumor microenvironment. PPBC mice deficient for phospho-eIF4E (eIF4ES209A) were protected against lung metastasis and exhibited differences in the tumor and lung immune microenvironment compared with wild-type mice. Moreover, the expression of fibroblast-derived IL33, an alarmin known to induce invasion, was repressed upon MNK1/2–eIF4E axis inhibition. Imaging mass cytometry on PPBC and non-PPBC patient samples indicated that human PPBC contains phospho-eIF4E high–expressing tumor cells and CD8+ T cells displaying markers of an activated dysfunctional phenotype. Finally, inhibition of MNK1/2 combined with anti–PD-1 therapy blocked lung metastasis of PPBC. These findings implicate the involvement of the MNK1/2–eIF4E axis during PPBC metastasis and suggest a promising immunomodulatory route to enhance the efficacy of immunotherapy by blocking phospho-eIF4E.

Significance:
This study investigates the MNK1/2–eIF4E signaling axis in tumor and stromal cells in metastatic breast cancer and reveals that MNK1/2 inhibition suppresses metastasis and sensitizes tumors to anti–PD-1 immunotherapy.
Quantitative Proteomics Identifies Secreted Diagnostic Biomarkers as well as Tumor-Dependent Prognostic Targets for Clear Cell Renal Cell Carcinoma
Authors: Senturk Aydanur , Sahin Ayse T. , Armutlu Ayse , Kiremit Murat C. , Acar Omer , Erdem Selcuk , Bagbudar Sidar , Esen Tarik , Tuncbag Nurcan , Ozlu Nurhan 
Published: May 2021

Abstract

Clear cell renal cell carcinoma (ccRCC) is the third most common and most malignant urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors. Here, we identified 10,160 unique proteins by in-depth quantitative proteomics, of which 955 proteins were significantly regulated between tumor and normal adjacent tissues. We verified four putatively secreted biomarker candidates, namely, PLOD2, FERMT3, SPARC, and SIRPα, as highly expressed proteins that are not affected by intratumor and intertumor heterogeneity. Moreover, SPARC displayed a significant increase in urine samples of patients with ccRCC, making it a promising marker for the detection of the disease in body fluids. Furthermore, based on molecular expression profiles, we propose a biomarker panel for the robust classification of ccRCC tumors into two main clusters, which significantly differed in patient outcome with an almost three times higher risk of death for cluster 1 tumors compared with cluster 2 tumors. Moreover, among the most significant clustering proteins, 13 were targets of repurposed inhibitory FDA-approved drugs. Our rigorous proteomics approach identified promising diagnostic and tumor-discriminative biomarker candidates which can serve as therapeutic targets for the treatment of ccRCC.

Implications:
Our in-depth quantitative proteomics analysis of ccRCC tissues identifies the putatively secreted protein SPARC as a promising urine biomarker and reveals two molecular tumor phenotypes.
Preoperative Risks of Cerebral Infarction in Pediatric Moyamoya Disease
Authors: Hayashi Toshiaki , Kimiwada Tomomi , Karibe Hiroshi , Shirane Reizo , Sasaki Tatsuya , Metoki Hirohito , Tominaga Teiji 
Published: May 2021

Background and Purpose:
In pediatric moyamoya disease, there have been few reports of the risk factors for preoperative cerebral infarction, especially during the waiting period before surgery. The clinical and radiological findings of surgically treated pediatric moyamoya patients were evaluated to analyze the risk factors for cerebral infarction seen from onset to surgery.

Methods:
Between August 2003 and September 2019, 120 hemispheres of 71 patients under 18 years of age with moyamoya disease were surgically treated by direct and indirect bypass procedures. The mean age of all surgical hemispheres at diagnosis was 6.7±3.9 years (6 months–17 years). The potential risk factors for preoperative infarction were examined statistically.

Results:

Multivariate logistic regression analysis showed that risk factors for infarction at the time of diagnosis were age at diagnosis (odds ratio [OR], 0.68 [95% CI, 0.57–0.82];
P
<0.0001) and the magnetic resonance angiography (MRA) score (OR, 2.29 [95% CI, 1.40–3.75];
P
=0.001). Univariate analysis showed that risk factors for infarction while waiting for surgery were age at diagnosis (OR, 0.61 [95% CI, 0.46–0.80];
P
<0.0001), the MRA score (OR, 1.75 [95% CI, 1.26–2.41];
P
=0.0003), and onset of infarction (OR, 40.4 [95% CI, 5.08–322.3];
P
<0.0001). Multiple comparisons showed that patients under 4 years of age were at a significantly high risk of infarction at the time of diagnosis and while waiting for surgery. Time from diagnosis to surgery of >2 months was a significant risk factor for infarction while waiting for surgery in patients under 6 years of age.

Conclusions:
Young age at diagnosis and a high MRA score may be associated with rapid disease progression and result in preoperative infarction. We recommend that surgery be performed within 2 months of diagnosis for the patients under 4 years of age with a high MRA score (>5) and cerebral infarction. Further study is needed to define the optimal timing of surgery.
Popular Print under the Press
Authors: Carnelos Laura 
Published: May 2021

Abstract
Mistakes, printing defects, reused woodcuts and low-quality paper are often the result of strategies enabled by printers and publishers to offer printed material at a low price while balancing profit/loss in their daily activities. It was precisely due to these strategies that a wider class of population could read, sing, learn and enjoy life in early modern Europe. This essay illustrates the preliminary results of a comparative analysis aimed at investigating the production phase of cheap books and prints all over Europe. With a focus on editorial strategies, printing practices and materials commonly adopted and used in these publications, it demonstrates that European publishers and printers followed very similar patterns while producing cheap products.
Dispute Settlement Mechanisms: Gulf Cooperation Council Practice v. European Union Practice
Authors: Hussain Fathi , Zahraa Mahdi 
Published: May 2021

Abstract
Dispute settlement mechanisms (DSM) are the heart of international organisations without which organisations would be ineffective. The European Union (EU) is probably the most effective regional body whose efficacy is largely due to its powerful judicial organ, the Court of Justice (CJEU). This article also examines the DSM available in the Gulf Cooperation Council (GCC), in order to assess its effectiveness. It briefly discusses aspects of the EU and CJEU to help provide suggestions to improve the GCC DSM. This article concludes that the GCC DSM lacks effectiveness due to an inherent defect in its DMS organs. This defect is twofold: first, the GCC has yet to establish an effective judicial organ to deal with its disputes; and, second, there is a lack of political will to establish an organ that is vested with a supranational power that can override the individual will of the Member States.
Inventory Analytics
Authors: Rossi Roberto 
Published: May 2021

Inventory Analytics provides a comprehensive and accessible introduction to the theory and practice of inventory control – a significant research area central to supply chain planning. The book outlines the foundations of inventory systems and surveys prescriptive analytics models for deterministic inventory control. It further discusses predictive analytics techniques for demand forecasting in inventory control and also examines prescriptive analytics models for stochastic inventory control.
Inventory Analytics is the first book of its kind to adopt a practicable, Python-driven approach to illustrating theories and concepts via computational examples, with each model covered in the book accompanied by its Python code. Originating as a collection of self-contained lectures, Inventory Analytics will be an indispensable resource for practitioners, researchers, teachers, and students alike.
Planetary-wave induced strengthening of the AMOC forced by poleward intensified Southern Hemisphere westerly winds
Authors: Webb D. J. , Spence P. , Holmes R. M. , England M. H. 
Published: May 2021

AbstractThe Atlantic meridional overturning circulation (AMOC) plays a key role in determining the distribution of heat and nutrients in the global ocean. Climate models suggest that Southern Ocean winds will strengthen and shift poleward in the future, which could have implications for future AMOC trends. Using a coupled global-ocean sea-ice model at 1/4°horizontal resolution, we study the response of the North Atlantic overturning to two anomalous Southern Ocean wind-forcing (τ+15%), and a poleward intensification(). In both scenarios a strengthening in the North Atlantic overturning develops within a decade, with a much stronger response in the case. In , we find that the primary link between the North Atlantic response and the Southern Ocean forcing is via the propagation of baroclinic waves. In fact, due to the rapid northward propagation of these waves, changes in the AMOC in the case appear to originate in the North Atlantic and propagate southward, whereas in the τ+15% case AMOC anomalies propagate northward from the Southern Ocean. We find the difference to be predominately caused by the sign of the baroclinic waves propagating from the forcing region into the North Atlantic; downwelling in the τ+15% case, versus upwelling in the case. In the case, upwelling waves propagating into the NADW formation regions along shelf-slope topography bringing dense water to the surface. This reduces vertical density gradients leading to deeper wintertime convective overturn of surface waters, and an intensification of the AMOC.
Cooperation without Consensus: Brokering Resiliency with Boundary Objects
Authors: Eisenhauer David C. 
Published: May 2021

AbstractThis paper presents a case study of how boundary objects were deployed to support a collaborative knowledge production process that resulted in the creation of climate change knowledge usable to municipal governments in the New Jersey shore region. In doing so, a case is made that boundary objects are useful throughout the collaborative process in overcoming ambiguity and disagreement. This points to boundary objects possessing a wider array of capabilities than is frequently theorized in the climate policy literature. Effectively designing and using boundary objects, however, requires carefully considering how they interface and interact with one another.