bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza clinical testing and oseltamivir treatment in hospitalized children with acute respiratory illness, 2015–2016
Authors: Hamdan Lubna , Probst Varvara , Haddadin Zaid , Rahman Herdi , Spieker Andrew J. , Vandekar Simon , Stewart Laura S. , Williams John V. , Boom Julie A. , Munoz Flor , Englund Janet A. , Selvarangan Rangaraj , Staat Mary A. , Weinberg Geoffrey A. , Azimi Parvin H. , Klein Eileen J. , McNeal Monica , Sahni Leila C. , Singer Monica N. , Szilagyi Peter G. , Harrison Christopher J. , Patel Manish , Campbell Angela P. , Halasa Natasha B. 
Published: October 2021

AbstractBackgroundAntiviral treatment is recommended for all hospitalized children with suspected or confirmed influenza, regardless of their risk profile. Few data exist on adherence to these recommendations, so we sought to determine factors associated with influenza testing and antiviral treatment in children.MethodsHospitalized children <18 years of age with acute respiratory illness (ARI) were enrolled through active surveillance at pediatric medical centers in seven cities between 11/1/2015 and 6/30/2016; clinical information was obtained from parent interview and chart review. We used generalized linear mixed‐effects models to identify factors associated with influenza testing and antiviral treatment.ResultsOf the 2299 hospitalized children with ARI enrolled during one influenza season, 51% (n = 1183) were tested clinically for influenza. Clinicians provided antiviral treatment for 61 of 117 (52%) patients with a positive influenza test versus 66 of 1066 (6%) with a negative or unknown test result. In multivariable analyses, factors associated with testing included neuromuscular disease (aOR = 5.35, 95% CI [3.58–8.01]), immunocompromised status (aOR = 2.88, 95% CI [1.66–5.01]), age (aOR = 0.93, 95% CI [0.91–0.96]), private only versus public only insurance (aOR = 0.78, 95% CI [0.63–0.98]), and chronic lung disease (aOR = 0.64, 95% CI [0.51–0.81]). Factors associated with antiviral treatment included neuromuscular disease (aOR = 1.86, 95% CI [1.04, 3.31]), immunocompromised state (aOR = 2.63, 95% CI [1.38, 4.99]), duration of illness (aOR = 0.92, 95% CI [0.84, 0.99]), and chronic lung disease (aOR = 0.60, 95% CI [0.38, 0.95]).ConclusionApproximately half of children hospitalized with influenza during the 2015–2016 influenza season were treated with antivirals. Because antiviral treatment for influenza is associated with better health outcomes, further studies of subsequent seasons would help evaluate current use of antivirals among children and better understand barriers for treatment.
Research topics in intellectual disabilities in North Korea: A scoping review
Authors: Kim Taehoon , Choi Soyoung , Lee Jun‐Young 
Published: October 2021

AbstractBackgroundResearch outcomes on intellectual development and related disabilities in North Korea are not widely known. Therefore, the current scoping review aimed to provide preliminary insight on research topics concerning intellectual disabilities in North Korea.MethodA six‐stage framework for scoping review was adopted to examine research trends. Articles were categorised based on the era of supreme leader and research topic.ResultsThere is a greater amount of research regarding intellectual disabilities in the recent Kim Jong‐un era compared to the period of the previous leader where research outcomes on general intelligence were the focus. Significant qualitative progress was similarly found.ConclusionsThe current analysis on research outcomes provides meaningful insights to aid in understanding the atmosphere in North Korea surrounding intellectual disabilities. Follow‐up studies and open discussions are necessary for further progress.
Argumentum ad populum: A reply to Bonikowski and DiMaggio
Authors: Eger Maureen A , Hjerm Mikael 
Published: October 2021

AbstractOur reply to Bonikowski and DiMaggio (2021) is in three parts. First, we clarify the aim of our research note (Eger & Hjerm, 2021). Our original critique was based on a replication of their inductive analysis, and we evaluated their work using best practices for the methodology that they chose. Our argument is straightforward: If one is going to use inductive methods to say something meaningful about the real world, one needs to make sure that the model being advanced fits the data. We present additional evidence supporting our original critique. Second, we discuss whether their new analyses bolster their original results and conclusions. Third, because their own results actually suggest that different levels of American nationalism exist rather than qualitatively different types, we question their claim of convergent validity. In short, we stand by our original critique.
Well‐being during the Great Recession: new evidence from a measure of multi‐dimensional living standards with heterogeneous preferences*
Authors: Boarini Romina , Fleurbaey Marc , Murtin Fabrice , Schreyer Paul 
Published: October 2021

AbstractWe develop a distribution‐adjusted welfare measure that aggregates income, unemployment, and longevity using individual weights that reflect heterogeneous preferences. The measure is implemented for 28 OECD countries for 2008–2013 to gauge the welfare effects of the Great Recession. Estimated shadow prices of one percentage point of unemployment and one year of longevity average 3.1 percent and 5.7 percent of household income, respectively. We find that the rate of GDP growth poorly reflects the social cost of the Great Recession. On average, GDP per capita stagnated across OECD countries between 2008 and 2013 while living standards of poor households fell by 5.3 percent annually.
Limiting factors for panicle photosynthesis at the anthesis and grain filling stages in rice (Oryza sativa L.)
Authors: Zhang Qiangqiang , Tang Wei , Peng Shaobing , Li Yong 
Published: October 2021

SUMMARYPanicle photosynthesis is crucial for grain yield in cereal crops; however, the limiting factors for panicle photosynthesis are poorly understood, greatly impeding improvement in this trait. In the present study, pot experiments were conducted to investigate the limiting factors for panicle photosynthesis at the anthesis stage in seven rice genotypes and to examine the temporal variations in photosynthesis during the grain filling stage in the Liangyou 287 genotype. At the anthesis stage, leaf and panicle photosynthesis was positively correlated with stomatal conductance and maximum carboxylation rate, which were in turn associated with hydraulic conductance and nitrogen content, respectively. Panicle hydraulic conductance was positively correlated with the area of bundle sheaths in the panicle neck. During grain filling, leaf and panicle photosynthesis remained constant at the early stage but dramatically decreased from 8 to 9 days after anthesis. The trends of variations in panicle photosynthesis were consistent with those in stomatal conductance but not with those in maximum carboxylation rate. At first, the maximum carboxylation rate and respiration rate in the panicle increased, through elevated panicle nitrogen content, but then drastically decreased, as a result of dehydration. The present study systematically investigated the limiting factors for panicle photosynthesis, which are vital for improving photosynthesis and crop yield.
Outcomes among adult survivors of total cavopulmonary Fontan palliation for single ventricle
Authors: Anigwe Christopher , Yogeswaran Vidhushei , Moon-Grady Anita , McAllister Sophie , Aggarwal Anika , Blissett Sarah , Harris Ian S , Kouretas Peter C , Mahadevan Vaikom S , Sabanayagam Aarthi , Agarwal Anushree 
Published: October 2021

ObjectiveThis tertiary centre study aims to identify factors associated with adverse outcomes in adult survivors with total cavopulmonary connection (TCPC) Fontan palliation for single ventricle.MethodsThis retrospective review of medical records identified adult (≥18 years) survivors of TCPC Fontan palliation who were followed at a single tertiary centre between 1 January 2000 and 1 July 2019. Adverse outcomes were defined as arrhythmia, pacemaker/implantable cardioverter defibrillator placement, liver cirrhosis, protein losing enteropathy, hospitalisation for heart failure, thromboembolic complication and/or death.Results160 adult TCPC patients met the inclusion criteria: 117 (73.1%) extracardiac and 43 (26.9%) lateral tunnel. The median (IQR) duration of follow-up since TCPC palliation was 17.5 (11.8–21.3) years. An adverse outcome occurred in 87 (54.4%) patients. Adverse outcome-free survival rates at 10, 20 and 25 years post TCPC were 89% (95% CI 82% to 93%), 60% (95% CI 50% to 69%) and 24% (95% CI 15% to 35%), respectively. On multivariate analysis, extracardiac Fontan (HR 2.21, 95% CI 1.20 to 4.08, p=0.011) was observed to be an independent risk factor for adverse outcomes after adjusting for age, race, morphology of the systemic ventricle and history of fenestration.ConclusionsIn this single-centre retrospective study of adult survivors of TCPC palliation, extracardiac Fontan was associated with an increased hazard for adverse outcomes. This finding could guide clinicians in developing risk modification strategies and management decisions to improve long-term outcomes in these patients.
Real-world performance of blood-based proteomic profiling in first-line immunotherapy treatment in advanced stage non-small cell lung cancer
Authors: Rich Patricia , Mitchell R Brian , Schaefer Eric , Walker Paul R , Dubay John W , Boyd Jason , Oubre David , Page Ray , Khalil Mazen , Sinha Suman , Boniol Scott , Halawani Hafez , Santos Edgardo S , Brenner Warren , Orsini James M , Pauli Emily , Goldberg Jonathan , Veatch Andrea , Haut Mitchell , Ghabach Bassam , Bidyasar Savita , Quejada Maria , Khan Waseemullah , Huang Kan , Traylor Linda , Akerley Wallace 
Published: October 2021

PurposeImmune checkpoint inhibition (ICI) therapy has improved patient outcomes in advanced non-small cell lung cancer (NSCLC), but better biomarkers are needed. A clinically validated, blood-based proteomic test, or host immune classifier (HIC), was assessed for its ability to predict ICI therapy outcomes in this real-world, prospectively designed, observational study.Materials and methodsThe prospectively designed, observational registry study INSIGHT (Clinical Effectiveness Assessment of VeriStrat® Testing and Validation of Immunotherapy Tests in NSCLC Subjects) (NCT03289780) includes 35 US sites having enrolled over 3570 NSCLC patients at any stage and line of therapy. After enrolment and prior to therapy initiation, all patients are tested and designated HIC-Hot (HIC-H) or HIC-Cold (HIC-C). A prespecified interim analysis was performed after 1-year follow-up with the first 2000 enrolled patients. We report the overall survival (OS) of patients with advanced stage (IIIB and IV) NSCLC treated in the first-line (ICI-containing therapies n=284; all first-line therapies n=877), by treatment type and in HIC-defined subgroups.ResultsOS for HIC-H patients was longer than OS for HIC-C patients across treatment regimens, including ICI. For patients treated with all ICI regimens, median OS was not reached (95% CI 15.4 to undefined months) for HIC-H (n=196) vs 5.0 months (95% CI 2.9 to 6.4) for HIC-C patients (n=88); HR=0.38 (95% CI 0.27 to 0.53), p<0.0001. For ICI monotherapy, OS was 16.8 vs 2.8 months (HR=0.36 (95% CI 0.22 to 0.58), p<0.0001) and for ICI with chemotherapy OS was unreached vs 6.4 months (HR=0.41 (95% CI 0.26 to 0.67), p=0.0003). HIC results were independent of programmed death ligand 1 (PD-L1). In a subgroup with PD-L1 ≥50% and performance status 0–1, HIC stratified survival significantly for ICI monotherapy but not ICI with chemotherapy.ConclusionBlood-based HIC proteomic testing provides clinically meaningful information for immunotherapy treatment decision in NSCLC independent of PD-L1. The data suggest that HIC-C patients should not be treated with ICI alone regardless of their PD-L1 expression.
Long-term steam conditioning is needed to maximize the nutritional value of expander-processed soybean expellers
Authors: Espinosa Charmaine D. , Oliveira Maryane S.F. , Limbach Joseph R. , Fanelli Natalia S. , Wiltafsky-Martin Markus K. , Stein Hans H. 
Published: October 2021

Two experiments were conducted to determine standardized ileal digestibility (SID) of amino acids (AA) and the concentration of metabolizable energy (ME) in non-heat-treated and heat-treated soybean expellers (L-0, L-12, and L-48). L-0 underwent short-term steam conditioning for 60 s, whereas L-12 and L-48 underwent short-term steam conditioning for 60 s and long-term steam conditioning for 12 or 48 min. All heat-treated soybean expellers were expander processed. In experiment 1, 10 ileal-cannulated barrows (54.22 ± 4.54 kg) were allotted to a replicated 5 × 4 Youden square design with eight replicate pigs per diet. Each source of soybean expellers was included in one diet, and a nitrogen-free diet was also used. Results indicated that the SID of AA in non-heat-treated soybean expellers was less (P < 0.01) than in heat-treated soybean expellers. In experiment 2, 40 barrows (17.52 ± 1.63 kg) housed in metabolism crates were allotted to a corn-based diet or four corn–soybean expellers diets. Feces and urine were collected with 5 d adaptation and 4 d collection periods. The ME in non-heat-treated soybean expellers was less (P < 0.01) compared with L-0, L-12, or L-48. In conclusion, the SID of AA and the ME in heat-treated soybean expellers were greater than in non-heat-treated soybean expellers.
Estimating abundance, temporary emigration, and the pattern of density dependence in a cyclic snowshoe hare (Lepus americanus) population in Yukon, Canada
Authors: Oli Madan K. , Kenney Alice J. , Boonstra Rudy , Boutin Stan , Chaudhary Vratika , Hines James E. , Krebs Charles J. 
Published: October 2021

Estimates of demographic parameters based on capture–mark–recapture (CMR) methods may be biased when some individuals in the population are temporarily unavailable for capture (temporary emigration). We estimated snowshoe hare abundance, apparent survival, and probability of temporary emigration in a population of snowshoe hares (Lepus americanus Erxleben, 1777) in the Yukon (Canada) using Pollock’s robust design CMR model, and population density using spatially explicit CMR models. Survival rates strongly varied among cyclic phases, seasons, and across five population cycles. We found strong evidence that temporary emigration was Markovian (i.e., nonrandom), suggesting that it varied among individuals that were temporary emigrant in the previous sampling period and those that were present in the sampled area. The probability of temporary emigration for individuals that were in the study area during the previous sampling occasion (γ″) varied among cycles. Probability that individuals that were temporarily absent from the sampled area would remain temporary emigrants (γ′) showed strongly seasonal pattern, low in winter and high during summers. Snowshoe hare population density ranged from 0.017 (0.015–0.05) hares/ha to 4.43 (3.90–5.00) hares/ha and showed large-scale cyclical fluctuations. Autocorrelation functions and autoregressive analyses revealed that our study population exhibited statistically significant cyclic fluctuations, with a periodicity of 9–10 years.
An in-flight plasma diagnostic package for spacecraft with electric propulsion
Authors: Trottenberg Thomas , Bansemer Florian , Böttcher Stephan , Feili Davar , Henkel Hartmut , Hesse Marcel , Kersten Holger , Krüger Tony , Laube Jens , Lazurenko Alexey , Sailer Daniel , Schuster Björn , Seimetz Lars , Spethmann Alexander , Weis Stefan , Wimmer-Schweingruber Robert F. 
Published: October 2021

AbstractThe plasma diagnostics presented in this article target the plasma surrounding a spacecraft that is created by the electric thruster and its surface modifying effects. The diagnostic package includes a retarding potential analyzer, a plane Langmuir probe, and an erosion sensor. The paper describes the instrument as well as suitable test environments for mimicking the effects expected in space and shows test results. The system is to fly for the first time on the Heinrich Hertz satellite, which is scheduled to be launched in 2023. The spacecraft will be equipped with a pair of Highly Efficient Multistage Plasma Thrusters (HEMPT) and a pair of Hall thrusters for redundancy.
Microwave Heating of Human Milk With Direct Temperature Monitoring
Authors: Yoshida Yurika , Azuma Minami , Furukawa Kazuna , Mizuno Katsumi , Den Hiroki , Kamiya Taro , Izumizaki Masahiko 
Published: October 2021

Background: Microwave heating can be effective in preventing cytomegalovirus infection transmitted via human milk. Temperature changes during microwaving using different containers, in different areas inside a container, or using milk from different mothers are not well studied. Research Aim: To determine temperature changes of human milk during microwaving using different containers, in different container areas, using different human milk, and in a 30-ml soft polypropylene bag (sachet) immersed in water. Methods: In this experimental in vitro study, human milk (100 ml) was poured into six different bottles. The temperature was monitored simultaneously at each bottle’s bottom and surface (microwaving at 600 W) and at nine places inside the container (microwaving at 500 W). Human milk (20 ml) from six participants was inserted into a sachet, then immersed in 80 ml of human milk or water in a bottle, and the temperatures inside and outside the sachet during microwaving (at 500 W) were monitored. Results: The temperature changes at the surface were significantly larger than those at the bottom. Temperatures at the bottoms of different bottles, of human milk from different participants, or inside and outside the sachet, did not differ significantly. No temperature outliers inside the bottle were observed. Conclusion: Microwaving at 500 W and 600 W for 60 s was not significantly different in temperature changes among different areas inside bottles or among milk from different participants. A small volume of human milk (up to 100 mL) can be heated using a sachet.
The Effectiveness of Personalisation on Health Outcomes of Older People: A Systematic Review
Authors: Fatoye Clara T. , Gebrye Tadesse , Fatoye Francis 
Published: October 2021

Purpose As people get older, they tend to have long-term conditions requiring health and social care intervention such as personalisation. Personalisation is person centred ensuring independence and control. To date, no systematic review has examined the effectiveness of personalisation. This review examined the effectiveness of personalisation in older people. Methods A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was undertaken. Databases searched included: Science Direct and Medline (PubMed) NHSEED and CINAHL. Inclusion criteria were older people living in their own homes receiving personalisation. Excluded were studies carried out in nursing homes. Newcastle-Ottawa Scale was used for quality of assessment. Results Search yielded 151 published studies with titles and abstracts; 143 studies were excluded and eight included. Studies included showed health outcomes of older people receiving personalisation improved significantly. Conclusions Review found evidence of improvement in quality of life and mobility in older people.
Elucidation of the molecular responses during the primary infection of wild blueberry phenotypes with Monilinia vaccinii-corymbosi under field conditions
Authors: Jose Sherin , Abbey Joel , Jaakola Laura , Percival David 
Published: October 2021

Abstract
Background
Monilinia blight caused by Monilinia vaccinii-corymbosi (Reade) Honey (M.vc) is a major disease of wild blueberry that can result in severe crop losses in the absence of an integrated disease management programme. The fungus causes blight in the emerging floral and vegetative buds, but the degree of susceptibility varies among the different wild blueberry phenotypes, ranging from the highly susceptible V. a. f. nigrum to the moderately susceptible V. angustifolium and the least susceptible V. myrtilloides.

Results
The present study evaluated the defense responses of these major phenotypes during their primary infection (floral buds) with M.vc. The temporal expression profiles of PR genes (PR3 and PR4) and the flavonoid pathway structural genes (CHS, ANS, ANR, DFR and FLS) were analysed. The PR3 and PR4 gene expression profiles revealed that V. myrtilloides responded to M.vc infection by activating the expression of both PR genes. V. a. f. nigrum, on the other hand, failed to activate these genes, while V. angustifolium, exhibited an intermediate response. Our study with the flavonoid pathway genes indicated variability in activation of the genes during post-infection time points with ANS and ANR in V. myrtilloides, FLS in V. angustifolium and no response observed in V. a. f. nigrum.

Conclusions
Altogether, this study highlights that the degree of phenotype susceptibility is associated with the timely activation of host defense responsive genes. Data obtained in this study provided a starting point for a better understanding of the wild blueberry- M. vaccinii-corymbosi pathosystem.
Neonatal sepsis in Sana’a city, Yemen: a predominance of Burkholderia cepacia
Authors: Salah Adeeb , Al-Subol Ibrahim , Hudna Ahmed , Alhaj Ali , Alqubaty Abdulhabib R. , Farie Waleed , Sulieman Dalal , Alnadhari Ola , Alwajeeh Talal , Alobathani Fawaz , Almikhlafy Abdullah , Mahdy Mohmmed A. K. 
Published: October 2021

AbstractBackgroundNeonatal sepsis is a global concern with increasing morbidity and mortality. The burden of neonatal sepsis is highest in developing countries, especially in those lacking proper surveillance systems. The causative pathogens and their drug-resistance levels vary between countries with emergence of multidrug resistance organisms. Thus, accurate records on the recent trends of organisms causing neonatal sepsis will provide vital information for appropriate intervention. We aimed to investigate neonatal sepsis, identify its associated factors and causative pathogens and to assess the antibiotic susceptibility patterns in Sana’a city, Yemen.MethodsA cross-sectional study was conducted on neonates admitted to intensive care units of six hospitals in Sana’a city, Yemen, in the period from January 15, to March 30, 2020. Natal and prenatal medical data were collected using well-structured questionnaire. Neonates were subjected to sepsis work-up including blood culture, complete blood count and C-reactive protein. Organisms were identified by Gram staining and analyzed by the VITEK II system for bacterial bio-typing and antibiotic susceptibility testing.FindingsOf the 199-neonates with suspected neonatal sepsis, 154 (77.38%) had culture-proven sepsis. Early-onset neonatal sepsis (EOS) was higher (50.25%; 100/199) than late-onset neonatal sepsis (LOS) (27.13%; 54/199). Multivariable analysis identified vaginal delivery as an independent risk factor for neonatal sepsisp = 0.005. Majority of isolated bacteria (74.39%) were gram-negative withBurkholderia cepacia(39%) andKlebsiella oxytoca(13%) being the most common pathogens of EOS and LOS. The most common gram-positive pathogens wereStaphylococcus haemolyticus(9.1%) andStaphylococcus epidermidis(7.1%).B. cepaciashowed multidrug resistance except for cefepime. AllKlebsiellaspecies isolates (100%) and mostPantoeaspecies (93%) were ESBL and carbapenemase positive. AllEscherichia coliandAcinetobacter baumanniiisolates were ESBL positive. A significant number of gram-positive bacteria showed resistance to vancomycin.ConclusionThe study findings show a high proportion of neonatal sepsis among neonates admitted to hospitals in Sana’a city with antibiotic-resistantB. cepaciabeing the single most common pathogen causing EOS and LOS. Findings also emphasize the emerging threat of multidrug-resistant bacteria in neonatal units and will help develop evidence-based management of neonatal sepsis in Yemen.