bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome
Authors: Yu Hai-Bo , Cheng Sheng-Tao , Ren Fang , Chen Yong , Shi Xiao-Feng , Wong Vincent Kam Wai , Law Betty Yuen Kwan , Ren Ji-Hua , Zhong Shan , Chen Wei-Xian , Xu Hong-Mei , Zhang Zhen-Zhen , Hu Jie-Li , Cai Xue-Fei , Hu Yuan , Zhang Wen-Lu , Long Quan-Xin , He Lin , Hu Zhong-Wen , Jiang Hui , Zhou Hong-Zhong , Huang Ai-Long , Chen Juan 
Published: June 2021

AbstractChronic hepatitis B virus (HBV) infection is a significant public health burden worldwide. HBV covalently closed circular DNA (cccDNA) organized as a minichromosome in nucleus is responsible for viral persistence and is the key obstacle for a cure of chronic hepatitis B (CHB). Recent studies suggest cccDNA transcription is epigenetically regulated by histone modifications, especially histone acetylation and methylation. In the present study, we identified transcriptionally active histone succinylation (H3K122succ) as a new histone modification on cccDNA minichromosome by using cccDNA ChIP-Seq approach. Silent mating type information regulation 2 homolog 7 (SIRT7), as an NAD+-dependent histone desuccinylase, could bind to cccDNA through interaction with HBV core protein where it catalyzed histone 3 lysine 122 (H3K122) desuccinylation. Moreover, SIRT7 acts cooperatively with histone methyltransferase, suppressor of variegation 3–9 homolog 1 (SUV39H1) and SET domain containing 2 (SETD2) to induce silencing of HBV transcription through modulation of chromatin structure. Our data improved the understanding of histone modifications of the cccDNA minichromosome, thus transcriptional silencing of cccDNA may represent a novel antiviral strategy for the prevention or treatment of HBV infection.
α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
Authors: Baena-Montes Jara M. , Avazzadeh Sahar , Quinlan Leo R. 
Published: June 2021

Abstract
α-synuclein is an increasingly prominent player in the pathology of a variety of neurodegenerative conditions. Parkinson’s disease (PD) is a neurodegenerative disorder that affects mainly the dopaminergic (DA) neurons in the substantia nigra of the brain. Typical of PD pathology is the finding of protein aggregations termed ‘Lewy bodies’ in the brain regions affected. α-synuclein is implicated in many disease states including dementia with Lewy bodies (DLB) and Alzheimer’s disease. However, PD is the most common synucleinopathy and continues to be a significant focus of PD research in terms of the α-synuclein Lewy body pathology. Mutations in several genes are associated with PD development including SNCA, which encodes α-synuclein. A variety of model systems have been employed to study α-synuclein physiology and pathophysiology in an attempt to relate more closely to PD pathology. These models include cellular and animal system exploring transgenic technologies, viral vector expression and knockdown approaches, and models to study the potential prion protein-like effects of α-synuclein. The current review focuses on human induced pluripotent stem cell (iPSC) models with a specific focus on mutations or multiplications of the SNCA gene. iPSCs are a rapidly evolving technology with huge promise in the study of normal physiology and disease modeling in vitro. The ability to maintain a patient’s genetic background and replicate similar cell phenotypes make iPSCs a powerful tool in the study of neurological diseases. This review focuses on the current knowledge about α-synuclein physiological function as well as its role in PD pathogenesis based on human iPSC models.
From electrons to Janskys: Full stokes polarized radiative transfer in 3D relativistic particle-in-cell jet simulations
Authors: MacDonald N. R. , Nishikawa K.-I. 
Published: June 2021

Context.Despite decades of dedicated observation and study, the underlying plasma composition of relativistic extragalactic jets remains largely unknown.Aims.Relativistic magnetohydrodynamic (RMHD) models are able to reproduce many of the observed macroscopic features of these outflows (e.g., recollimation shocks, jet sheaths and spines, bow shocks, and enshrouding jet cocoons). The nonthermal synchrotron emission detected by very long baseline interferometric arrays, however, is a by-product of the kinetic-scale physics occurring within the jet, physics that is not modeled directly in most RMHD codes. This paper attempts to discern the radiative differences between distinct plasma compositions within relativistic jets using small-scale 3D relativistic particle-in-cell (PIC) simulations.Methods.We made use of a polarized radiative transfer scheme to generate full Stokes imaging of two PIC jet simulations, one in which the jet is composed of an electron-proton (e− − p+) plasma (i.e., a normal plasma jet), and the other in which the jet is composed of an electron-positron (e− − e+) plasma (i.e., a pair plasma jet). We examined the differences in the morphology and intensity of the linear polarization and circular polarization (CP) emanating from these two jet simulations.Results.Our PIC simulations, when scaled into physical units, are ∼150 cubic kilometers in size. We find that the fractional level of CP (measured relative to integrated total intensity) emanating from thee− − p+plasma jet is orders of magnitude larger than the level emanating from ane− − e+plasma jet of a similar speed and magnetic field strength. In addition, we find that the morphology of both the linearly and circularly polarized synchrotron emission is distinct between the two jet compositions. These results highlight the following: (i) the potential of high-resolution full-Stokes polarimetric imaging to discern between normal plasma and pair plasma jet emission in larger scale systems and (ii) the challenges faced by kinetic simulations in modeling this emission self-consistently. We also demonstrate the importance of slow-light interpolation and we highlight the effect that a finite light-crossing time has on the resultant polarization when ray-tracing through relativistic plasma. Placing a firm constraint on the plasma content of relativistic extragalactic jets will help to advance our understanding of jet feedback.
No Clinically Meaningful Differences in 1-Year Patient-Reported Outcome Measures between Hip Resurfacing and Total Hip Arthroplasty: An Age-Matched Prospective Cohort Study
Authors: Siqueira Marcelo ,   Cleveland Clinic OME Arthroplasty Group
Published: June 2021

AbstractThis study compared patient-reported outcome measures (PROMs), readmissions, and reoperations between hip resurfacing (HR) and total hip arthroplasty (THA) in a matched prospective cohort. Between 2015 and 2017, 4,268 patients underwent HR or THA at a single institution. A prospective cohort of 2,147 patients were enrolled (707 HRs, 1,440 THAs). PROMs were collected at baseline and 1-year follow-up. Exclusion criteria: females (n = 2,008), inability/refusal to complete PROMs (n = 54), and diagnosis other than osteoarthritis (n = 59). Each HR patient was age-matched to a THA patient. Multivariate regression models were constructed to control for race, body mass index, education, smoking status, Charlson Comorbidity Index, mental health, and functional scores. A significance threshold was set at p = 0.017. A total of 707 HRs and 707 THAs were analyzed and 579 HRs (81.9%) and 490 THAs (69.3%) were followed up at 1 year. There was no statistically significant difference for Hip Injury and Osteoarthritis Outcomes Score (HOOS) Pain subscale (p = 0.129) and HOOS-Physical Function Shortform (HOOS-PS) (p = 0.03). HR had significantly higher median University of California in Los Angeles (UCLA) activity scores (p = 0.004). Ninety-day readmissions for HR and THAs were 1.8 and 3.5%, respectively (p = 0.06), and reoperations at 1 year were 1.2 and 2.3%, respectively (p = 0.24). For male patients, differences in medians for UCLA activity scores were 0.383 points, which were statistically significant but may not be clinically relevant. No differences exist in 90-day readmissions, reoperations, and HOOSpain and HOOS-PS scores. Because patients undergoing HR are advised to return to full activity at 1-year postoperative, follow-up is required. Metal ion levels were not obtained postoperatively for either group.
The Current Role of Platelet Function Testing in Clinical Practice
Authors: Mason George A. , Rabbolini David J. 
Published: June 2021

AbstractPlatelet dysfunction, whether hereditary or acquired, may increase an individual's risk of spontaneous, posttraumatic, or postoperative bleeding. Conversely, increased platelet reactivity on antiplatelet agents following vascular (in particular, coronary vascular) intervention may increase the risk of thrombosis and adverse vascular events. The aim of platelet function testing is to identify and characterize platelet dysfunction in these settings to inform bleeding/ thrombosis risk and guide perioperative prophylactic management strategies. A vast array of screening and diagnostic tests is available for this purpose. The successful clinical application of platelet function tests depends on the knowledge of their analytical strengths and limitations and the correct extrapolation of derived results to a particular clinical scenario. This review critically appraises traditional and contemporary platelet function testing focusing on their role in clinical practice.
What Factors Reduce the Incidence of Early Dislocations in Aseptic Total Hip Revisions with Stem Retention?
Authors: Villa Jesus M. , Pannu Tejbir S. , Patel Preetesh D. , Barsoum Wael K. , Higuera Carlos A. , Riesgo Aldo M. 
Published: June 2021

AbstractIt is unclear which factors are the most important protectors for early postoperative dislocation in aseptic total hip arthroplasty (THA) revisions with stem retention. Therefore, we sought to determine what factors reduce the incidence of dislocations among these patients. Single institution retrospective review was made of 83 consecutive aseptic THA revisions of the head/liner and/or cup performed by five surgeons between 2017 and 2020. Periprosthetic infections and femoral component revisions were excluded. Demographics, preoperative diagnosis, revision type, surgical approach, use of dual mobility systems, length of stay, skin-to-skin time, transfusions, complications, and dislocations were assessed. Pearson correlation/logistic regression analyses were used to determine association/independent predictors of dislocation; α was set at 0.05. The overall dislocation rate was 12%. In Pearson correlation, only preoperative diagnosis (instability vs. other, −0.241, p = 0.028) and revision type (only liner vs. cup, −0.304, p = 0.005) were significantly associated with dislocations. In logistic regression, only preoperative diagnosis other than instability (odds ratio [OR] = 0.235, p = 0.038) and cup revision (OR = 0.130, p = 0.014) were found significant protectors against dislocation. Surgical approach and dual mobility systems were not independent predictors of dislocations (p = 0.184 and p = 0.083, respectively). Dislocation rates were significantly different between those cases that had the cup revised (4.0%) and those that did not (24.2%; p = 0.012). Preoperative diagnosis other than instability and cup revision seemed to be protective against early dislocation. Revision of the cup, in particular, seemed to be the most important factor to avoid dislocations while use of dual mobility liners per se did not significantly reduce that risk. The role of isolated liner exchanges in revision THA continues to evolve and should be reserved for appropriately selected patients.
Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin
Authors: Fernández Delia I. , Veninga Alicia , Tullemans Bibian M. E. , Baaten Constance C. F. M. J. , Peters Linsey J. F. , Aarts Maureen J. B. , Eble Johannes A. , Campello Elena , Spiezia Luca , Simioni Paolo , van der Vorst Emiel P. C. , van der Meijden Paola E. J. , Heemskerk Johan W. M. , Kuijpers Marijke J. E. 
Published: June 2021

Abstract
Background Sunitinib is a multitarget tyrosine kinase inhibitor (TKI) used for cancer treatment. In platelets, sunitinib affects collagen-induced activation under noncoagulating conditions. We investigated (1) the effects of sunitinib on thrombus formation induced by other TK-dependent receptors, and (2) the effects under coagulating conditions. Cardiovascular disease is a comorbidity in cancer patients, resulting in possible aspirin treatment. Sunitinib and aspirin are associated with increased bleeding risk, and therefore we also investigated (3) the synergistic effects of these compounds on thrombus and fibrin formation.
Methods Blood or isolated platelets from healthy volunteers or cancer patients were incubated with sunitinib and/or aspirin or vehicle. Platelet activation was determined by TK phosphorylation, flow cytometry, changes in [Ca2+]i, aggregometry, and whole blood perfusion over multiple surfaces, including collagen with(out) tissue factor (TF) was performed.
Results Sunitinib reduced thrombus formation and phosphatidylserine (PS) exposure under flow on collagen type I and III. Also, sunitinib inhibited glycoprotein VI-induced TK phosphorylation and Ca2+ elevation. Upon TF-triggered coagulation, sunitinib decreased PS exposure and fibrin formation. In blood from cancer patients more pronounced effects of sunitinib were observed in lung and pancreatic as compared to neuroglioblastoma and other cancer types. Compared to sunitinib alone, sunitinib plus aspirin further reduced platelet aggregation, thrombus formation, and PS exposure on collagen under flow with(out) coagulation.
Conclusion Sunitinib suppresses collagen-induced procoagulant activity and delays fibrin formation, which was aggravated by aspirin. Therefore, we urge for awareness of the combined antiplatelet effects of TKIs with aspirin, as this may result in increased risk of bleeding.
US-China trade negotiation discourses in the press
Authors: Li Jiayu 
Published: June 2021

AbstractThis article studies trade negotiation discourses during the US-China tariff truce, aiming at investigating the difference of ideologies of the U.S. and China journalists towards trade negotiation. Through integration of theories and methods of corpus linguistics and critical discourse studies and the use of the corpus linguistic software, the study finds that U.S. reports to some extent make itself appear as a victim of the trade, and hope to end unfair trade practices and reduce the chronic trade deficit, while China press focuses more on the harm of raising tariffs not just to each other but the global economy, through communication and dialogue rather than unilateral measures to peacefully resolve trade tensions. Perceived differences in culture have an important influence in the theoretical formation of the differences. The article concludes that the discourse patterns of the coverage imply a rising China and a new level of equilibrium in international politics.
The Inter-Agency Committee on Radiation Safety—30 years of international coordination of radiation protection and safety matters
Authors: Mundigl Stefan , Blackburn Carl , Pinak Miroslav , Colgan Tony , Clement Christopher , Otto Thomas , Voytchev Miroslav , Niu Shengli , Coates Roger , Guen Bernard Le , Rannou Alain , Lazo Edward , Garnier-Laplace Jacqueline , Jimenez Pablo , Batandjieva-Metcalf Borislava , Shannoun Ferid , Pérez Maria Del Rosario 
Published: June 2021

Abstract
The Inter-Agency Committee on Radiation Safety (IACRS) was constituted in 1990, as a forum for collaboration and coordination between international bodies with regards to radiation safety. It consists today of representatives of eight intergovernmental member organizations (the European Commision, Food and Agriculture Organization, International Atomic Energy Agency (IAEA), International Labour Office, Organisation for Economic Co-operation and Development/ Nuclear Energy Agency (OECD/NEA), Pan American Health Organization, United Nations Scientific Committee on the Effects of Atomic Radiation and the World Health Organization) and five observer non-governmental organizations (International Commission on Radiological Protection, International Commission on Radiation Units & Measurements, International Electrotechnical Commission, International Radiation Protection Association and International Organization for Standardization). The IACRS provides a platform for interaction between these relevant international bodies to contribute to a common understanding of the scientific basis and legal framework for the application of the system of radiation protection, towards global harmonisation of radiation safety standards. The IACRS played a key role in the development of the International Basic Safety Standards (BSS) in 1996 and in its revision in 2014. Further, an IACRS specific Task Group—chaired by the IAEA—fosters the implementation of the BSS in a consistent and coherent manner in all Member States of the United Nations. The IACRS operates via a standing secretariat jointly provided by the IAEA and OECD/NEA and is chaired by one of its member organizations on a rotating basis for periods of about 18 months. This approach has proved to be effective and was the foundation for ensuring continuity of the work of the committee and at the same time allowing a rotating leadership for all member organizations. Currently, the IACRS is chaired by the WHO. The International Radiation Safety Framework under which the IACRS works is structured around four main areas: (a) science; (b) principles; (c) standards; and (d) practice. This paper presents briefly the mandates, roles and functions of the various international bodies that are relevant to the four above mentioned areas of work, discusses how these bodies coordinate their actions and complement each other to enhance radiation protection and safety worldwide and describes their contribution to the achievement of the Sustainable Development Goals. The paper also provides an overview of the main accomplishments of the IACRS since its inception 30 years ago, and an outlook on key challenges for its future activities.
Coherence of oscillations in matter and
supernova neutrinos
Authors: Porto-Silva Yago P. , Smirnov Alexei Yu. 
Published: June 2021

Abstract
We study the propagation coherence for neutrino oscillations in
media with different density profiles.
For each profile, we find the dependence of the
coherence length, Lcoh, on neutrino energy and
address the issue of correspondence
of results in the distance and energy-momentum representations.
The key new feature in matter is existence of
energy ranges with enhanced coherence around the energies
E0 of “infinite coherence” at which Lcoh→∞.
In the configuration space, the infinite coherence corresponds
to equality of the (effective) group velocities of the eigenstates.
In constant density medium, there is a unique E0, which coincides with the MSW resonance energy of oscillations of mass states and is close to the MSW resonance energy of flavor states.
In the case of massless neutrinos or negligible masses in a very dense
medium
the coherence persists continuously.
In the adiabatic case, the infinite coherence is realized for periodic
density change. Adiabaticity violation changes the shape factors of
the wave packets (WPs) and leads to their spread. In a medium with sharp density
changes (jumps), splitting of the eigenstates occurs at crossing
of each jump. We study the increase of the coherence length
in a single jump and periodic density jumps — castle-wall (CW) profiles.
For the CW profile, there are several E0 corresponding to parametric resonances. We outlined applications of the results for supernova neutrinos.
In particular, we show that coherence between two shock wave fronts leads to observable oscillation effects, and our analysis suggests that the decoherence can be irrelevant for flavor transformations in the central parts of collapsing stars.
Inclusive production of fully-charmed 1+− tetraquark at B factory *
Authors: Huang Yingsheng , Feng Feng , Jia Yu , Sang Wen-Long , Yang De-Shan , Zhang Jia-Yue 
Published: June 2021

Abstract
Inspired by the recent discovery of the

meson in the

experiment, we investigate the inclusive production rate of the

-odd fully-charmed tetraquarks associated with light hadrons at the

factory within the nonrelativistic QCD (NRQCD) factorization framework. The short-distance coefficient is computed at the lowest order of velocity and

. Employing two different kinds of phenomenological models to approximately estimate the long-distance NRQCD matrix element, we predict the rate for the inclusive production of the

state and discuss the observation prospect of the

experiment.
Effect of pairing correlation on low-lying quadrupole states in Sn isotopes *
Authors: Sun Shuai , Zhang Shi-Sheng , Zhang Zhen-Hua , Cao Li-Gang 
Published: June 2021

Abstract
We examined the low-lying quadrupole states in Sn isotopes in the framework of fully self-consistent Hartree-Fock+BCS plus QRPA. We focus on the effect of the density-dependence of pairing interaction on the properties of the low-lying quadrupole state. The SLy5 Skyrme interaction with surface, mixed, and volume pairings is employed in the calculations, respectively. We find that the excitation energies and the corresponding reduced electric transition probabilities of the first 2+ state are different, given by the three pairing interactions. The properties of the quasiparticle state, two-quasiparticle excitation energy, reduced transition amplitude, and transition densities in 112Sn are analyzed in detail. Two different mechanisms, the static and dynamical effects, of the pairing correlation are also discussed. The results show that the surface, mixed, and volume pairings indeed affect the properties of the first 2+ state in the Sn isotopes.
NLO effects for ΩQQQbaryons in QCD Sum Rules *
Authors: Wu Ren-Hua , Zuo Yu-Sheng , Meng Ce , Ma Yan-Qing , Chao Kuang-Ta 
Published: June 2021

AbstractWe study the triply heavy baryonsin the QCD sum rules by performing the first calculation of the next-to-leading order (NLO) contribution to the perturbative QCD part of the correlation functions. Compared with the leading order (LO) result, the NLO contribution is found to be very important to the. This is because the NLO not only results in a large correction but also reduces the parameter dependence, making the Borel platform more distinct, especially for thein thescheme, where the platform appears only at NLO but not at LO. Particularly, owing to the inclusion of the NLO contribution, the renormalization schemes (and On-Shell) dependence and the scale dependence are significantly reduced. Consequently, after including the NLO contribution to the perturbative part in the QCD sum rules, the masses are estimated to beGeV forandGeV for, where the results are obtained atwith errors including those from the variation of the renormalization scaleμin the range. A careful study of theμdependence in a wider range is further performed, which shows that the LO results are very sensitive to the choice ofμwhereas the NLO results are considerably better. In addition to theresult, a more stable value, (4.75-4.80) GeV, for themass is found in the range of, which should be viewed as a more relevant prediction in our NLO approach because ofdependence.