bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acclimation with humic acids enhances maize and tomato tolerance to salinity
Authors: Souza Aline Costa , Zandonadi Daniel Basílio , Santos Mirella Pupo , Canellas Natália Oliveira Aguiar , de Paula Soares Cleiton , da Silva Irineu Luiz Eduardo Souza , de Rezende Carlos Eduardo , Spaccini Riccardo , Piccolo Alessandro , Olivares Fabio Lopes , Canellas Luciano Pasqualoto 
Published: August 2021

AbstractBackgroundSalinity is one of the major environmental threats to agriculture, limiting plant growth and reducing crop yield. The use of humic substances to alleviate salt stress in plants is well reported, but the mechanisms remain unclear. This work aimed to apply humic acids on seedlings to acclimate plants to tolerate further salt stress exposition as a pre-treatment.Materials and methodsTwo independent experiments with mono (maize) and dicot (tomato) seedlings were carried out. Maize was primed by humic acids (4 mM C) and further submitted to moderate salinity exposition (60 mM NaCl). The acclimation period of maize seedlings was characterized by ion balance and transcriptomic analysis of salt response genes. The tomato seedlings were also primed by humic acids (4 mM C) and exposed further to salinity (200 mM NaCl), and we measured only physiological aspect, including the activity of plasma membrane proton pumps and net photosynthesis rate.ResultsSeedlings primed by humic acids minimized the salinity stress by changing ion balance, promoting plasma membrane proton pumps activity and enhancing photosynthesis rate and plant growth. We showed for the first time that maize seedlings treated with humic acids had a high transcription level of salt responsive genes and transcription factors even before the salt exposition.ConclusionHumic acids previously activate cellular and molecular salt defence machinery, anticipating the response and reducing salinity stress. This is a key knowledge to manipulate manufactured biostimulants based on humic substances towards a maximized crop protection.Graphic abstract
A web-based prospective cohort study of home, leisure, school and sports injuries in France: a descriptive analysis
Authors: Rojas Castro Madelyn Yiseth , Orriols Ludivine , Basha Sakr Dunia , Contrand Benjamin , Dupuy Marion , Travanca Marina , Sztal-Kutas Catherine , Avalos Marta , Lagarde Emmanuel 
Published: August 2021

Abstract
Background
Home and leisure injuries (HLIs) are a major public health problem. Cohort studies among general population are needed for targeted preventive actions but remain scarce. We quantify and qualify the HLIs collected prospectively in the MAVIE (Mutualists against Home and Leisure Injuries) observatory, a web-based cohort among volunteers of the French general population.

Methods
Participants reported HLIs from November 2014 to December 2019. We calculated crude and standardized incidence rates (SIRs) on the entire cohort, for each of the selected socio-demographic variables and each of the injury circumstances (place and activity), mechanisms, and injury severity levels. We also described other HLIs characteristics and consequences.

Results
Out of the 29,931 household members enrolled in the cohort, 12,419 participants completed the questionnaires. Among them, 8640 participants provided follow-up data, leading to a follow-up of 6302 persons for 5.2 years and 2483 HLIs were reported. We obtained a SIR of 85.0 HLIs per 1000 persons-years. Most reported injuries did not require emergency department attendance or hospitalization (64%). SIRs were higher in children (< 15 years of age) (109.1 HLIs per 1000 persons-years; 95% CI, 78.2–140.1) and adults aged 70 years and older (123.7 HLIs per 1000 persons-years; 95% CI, 79.2–168.3). Struck or hit by fall was the most frequent injury mechanism (52%) and also among the most severe injuries (73% of Struck or hit by fall HLIs ending with hospitalization). Sport (without contact with nature), and leisure and play activities were the injury circumstances with higher SIRs, 15.2 HLIs per 1000 persons-years (95% CI, 14.6–15.8) and 11.2 HLIs per 1000 persons-years (95% CI, 10.7–11.6), respectively. Outdoor sport activity (in contact with nature) was the circumstance with the highest proportion of hospitalizations (18% of outdoor sports HLIs ending with hospitalization).

Conclusion
The incidences, causes, and consequences of HLI differ by age group and are mainly related to the performance of certain activities. Although the participants in the MAVIE cohort were not representative of the French population. Our study identified potential sub-populations and specific types of HLIs that should be targeted by future studies concerning risk factors and prevention programs.
Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes
Authors: Iuliano Lorenzo , Cisa di Gresy Gloria , Fogliato Giovanni , Corbelli Eleonora , Bandello Francesco , Codenotti Marco 
Published: August 2021

Abstract
Purpose
To assess the rate of occurrence and the risk factors of postsurgical macular edema (PSME) in eyes with idiopathic epiretinal membrane (iERM) or full-thickness macular hole (FTMH).

Methods
Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined cataract surgery over a 6-month period. Electronic medical charts and imaging data were analyzed preoperatively and at 1, 3 and 6 months after surgery.

Results
From 101 patients diagnosed with iERM or FTMH, 71 patients were eligible for the study. Forty-nine eyes with iERM (69.0%) and 22 eyes with FTMH (31.0%) underwent vitrectomy either isolated (31.0%) or combined with cataract extraction (69.0%). The overall rate of PSME was 26.7%, without differences between the two groups (P = 0.9479). Combined cataract extraction did not affect the overall occurrence of PSME rate in both groups (P = 0.9255 in FTMH and P = 0.8658 in iERM). If grouped by stage, eyes with stage 4 iERM though disclosed an increased rate of PSME (57.1%) compared to lower (1 to 3) stages (14.3%, P = 0.0021), particularly when combined with cataract surgery (71.4% vs. 15.4% in stages ≤ 3, P = 0.0021). The PSME odds ratio for a stage 4 iERM is 8 (95% CI: 1.933–33.1; P = 0.0041) compared to stages 3 and below.

Conclusions
PSME remains a clinically relevant and frequent event after surgery for iERM and FTMH. Patients with stage 4 iERM have an 8-fold higher likelihood of developing PSME in a 6-month postsurgical period compared to iERM in 1–3 stages, especially when combined with cataract extraction.
Combined treatment of an aortosplenic bypass followed by coil embolization in the treatment of pancreaticoduodenal artery aneurysms caused by median arcuate ligament compression: a report of two cases
Authors: Kii Shuhei , Kamachi Hirofumi , Abo Daisuke , Kato Takuya , Tsuruga Yousuke , Wakayama Kenji , Kakisaka Tatsuhiko , Soyama Takeshi , Kamiyama Toshiya , Ooka Tomonori , Wakasa Satoru , Taketomi Akinobu 
Published: August 2021

Abstract
Background
Pancreaticoduodenal artery aneurysms (PDAAs) are rare visceral aneurysms, and prompt intervention/treatment of all PDAAs is recommended at the time of diagnosis to avoid rupture of aneurysms. Herein, we report two cases of PDAA caused by the median arcuate ligament syndrome, treated with surgical revascularization by aortosplenic bypass followed by coil embolization.

Case presentation
Case 1 A 54-year-old woman presented with a chief complaint of severe epigastralgia and was diagnosed with two large fusiform inferior PDAAs and celiac axis occlusion. To preserve the blood flow of the pancreatic head, duodenum, liver, and spleen, we performed elective surgery to release the MAL along with aortosplenic bypass. At 6 days postoperatively, transcatheter arterial embolization was performed. At the 8-year 6-month follow-up observation, no recurrent perfusion of the embolized PDAAs or rupture had occurred, including the non-embolized small PDAA, and the bypass graft had excellent patency.
Case 2 A 39-year-old man who had been in good health was found to have a PDAA with celiac stenosis during a medical checkup. Computed tomography and superior mesenteric arteriography showed severe celiac axis stenosis and a markedly dilated pancreatic arcade with a large saccular PDAA. To preserve the blood flow of the pancreatic arcade, we performed elective surgery to release the MAL along with aortosplenic bypass. At 9 days postoperatively, transcatheter arterial embolization was performed. At the 6-year 7-month follow-up observation, no recurrent perfusion or rupture of the PDAA had occurred, and the bypass graft had excellent patency.

Conclusion
Combined treatment with bypass surgery and coil embolization can be an effective option for the treatment of PDAAs associated with celiac axis occlusion or severe stenosis.
Neurological manifestations in mild and moderate cases of COVID-19
Authors: Abdel Azim Ghada Saed , Osman Marwa Abdellah 
Published: August 2021

Abstract
Background
The coronavirus disease due to SARS COVID-2 emerged from Wuhan city in China in December 2019 and rapidly spread to more than 200 countries all over the world as a global health pandemic. Its primary presentation is respiratory and cardiac. However, some neurological manifestations are also reported. We tried to explore the reported neurological manifestations in a group of non-hospitalized mild and moderate COVID-19 patients. We contacted 107 patients via phone calls and e-mail messages, within 10 days of clinical presentation. The collected data regarded the neurological and non-neurological symptoms of the disease using a questionnaire that collected medical information of each patient.

Results
It is found that 100% of patients have been reported with at least one neurological symptom during the first 10 days of COVID-19 presentation. The most common were headache which recorded 72% of the total. Then anosmia–dysgeusia which reached 52%, then myalgia with 44%, fatigue with 33% and dizziness with 32%. While the less common was numbness, migraine, loss of concentration, and seizures.

Conclusion
There are many neurological manifestations found to be very common in COVID-19 patients even in mild cases, which when added to the increasing reports of serious cases of Guillain–Barre syndrome, acute necrotizing encephalopathy, myelitis, stroke, and encephalitis in COVID-19 patients support CNS invasion of the virus and assures the importance of neurological assessment of COVID-19 patients both in the acute phase of infection and after recovery for potential neurological sequelae.
The pillars determining financial inclusion among SMEs in Egypt: service awareness, access and usage metrics and macroeconomic policies
Authors: ElDeeb Mohamed Samy , Halim Yasser Tawfik , Kamel Esmat Mostafa 
Published: August 2021

AbstractOver the past decade, financial inclusion has been a trending topic and key priority in developing countries seeking to build a resilient financial sector and pursuing economic growth. Most of the recently launched financial inclusion initiatives in Egypt, especially those aligned with the 2030 sustainability strategy, have targeted marginalized and excluded individuals. Only a few have addressed the financial inclusion of small- and medium-sized enterprises (SMEs). Accordingly, this paper aims to identify the main pillars of financial inclusion for SMEs. In keeping up with the mainstream literature, it introduces a number of financial inclusion determinants designed to attract SMEs. They include supply-side determinants such as access to financial services and marketing awareness campaigns, which act as tools to segment financial services and market their benefits to SMEs, and demand-side determinants, which involve the use of financial services. Finally, there is an assessment of the macroeconomic risks to investors and SMEs. The researchers’ methodology was based on first deriving a novel dataset from responses to a questionnaire addressing bankers who manage SME portfolios, second analyzing the dataset through descriptive and inferential statistics and third undertaking a twofold econometric estimation. The econometric estimations started with principal component analysis (PCA) and proceeded to a logistic regression to determine the significant variables pertinent to increasing the financial inclusion of SMEs. The PCA suggested three main pillars determining financial inclusion. They are integrated marketing tools, which increase SMEs’ awareness of and access to the most sophisticated banking services, usage of banking services, and assessment of the macroeconomic risks that would prevent SMEs from gaining access to financial services. As well, the interaction term between the variables derived from the three pillars accounts for a variability of 86.6% in the level of financial inclusion of Egypt’s SMEs.
Phase I or II Study of Ribociclib in Combination With Topotecan-Temozolomide or Everolimus in Children With Advanced Malignancies: Arms A and B of the AcSé-ESMART Trial
Authors: Bautista Francisco , Paoletti Xavier , Rubino Jonathan , Brard Caroline , Rezai Keyvan , Nebchi Souad , Andre Nicolas , Aerts Isabelle , De Carli Emilie , van Eijkelenburg Natasha , Thebaud Estelle , Corradini Nadege , Defachelles Anne-Sophie , Ducassou Stephane , Morscher Raphael J. , Vassal Gilles , Geoerger Birgit 
Published: August 2021

PURPOSE AcSé-ESMART is a proof-of-concept, phase I or II, platform trial, designed to explore targeted agents in a molecularly enriched cancer population. Arms A and B aimed to define the recommended phase II dose and activity of the CDK4/6 inhibitor ribociclib with topotecan and temozolomide (TOTEM) or everolimus, respectively, in children with recurrent or refractory malignancies. PATIENTS AND METHODS Ribociclib was administered orally once daily for 16 days after TOTEM for 5 days (arm A) or for 21 days with everolimus orally once daily continuously in a 28-day cycle (arm B). Dose escalation followed the continuous reassessment method, and activity assessment the Ensign design. Arms were enriched on the basis of molecular alterations in the cell cycle or PI3K/AKT/mTOR pathways. RESULTS Thirty-two patients were included, 14 in arm A and 18 in arm B, and 31 were treated. Fourteen patients had sarcomas (43.8%), and 13 brain tumors (40.6%). Main toxicities were leukopenia, neutropenia, and lymphopenia. The recommended phase II dose was ribociclib 260 mg/m2 once a day, temozolomide 100 mg/m2 once a day, and topotecan 0.5 mg/m2 once a day (arm A) and ribociclib 175 mg/m2 once a day and everolimus 2.5 mg/m2 once a day (arm B). Pharmacokinetic analyses confirmed the drug-drug interaction of ribociclib on everolimus exposure. Two patients (14.3%) had stable disease as best response in arm A, and seven (41.2%) in arm B, including one patient with T-acute lymphoblastic leukemia with significant blast count reduction. Alterations considered for enrichment were present in 25 patients (81%) and in eight of nine patients with stable disease; the leukemia exhibited CDKN2A/B and PTEN deficiency. CONCLUSION Ribociclib in combination with TOTEM or everolimus was well-tolerated. The observed activity signals initiated a follow-up study of the ribociclib-everolimus combination in a population enriched with molecular alterations within both pathways.
Study on the periodic solution of the (3 + 1)-dimensional extended quantum Zakharov-Kuznetsov equation in plasma physics
Authors: Wang Kang-Jia , Wang Guo-Dong 
Published: August 2021

Abstract
In the current work, we consider the (3 + 1)-dimensional extended quantum Zakharov-Kuznetsov (Z-K) equation which is used widely to explain the propagations of the waves arising in plasma physics. The variational theory together with the Hamiltonian method are employed to construct the periodic solution of the equation. As expected, the obtained solution agrees well with the solution by He's variational method, which strongly proves the correctness of the proposed method. Finally, we illustrate the solutions through one example in the form of 3-D and 2-D plots. The obtained results show that the method is simple but effective, which is expected to shed a bright light on the study of the nonlinear partial differential equations arising in physics.
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts
Authors: Grosch Melanie , Brunner Katrin , Ilyaskin Alexandr V. , Schober Michael , Staudner Tobias , Schmied Denise , Stumpp Tina , Schmidt Kerstin N. , Madej M. Gregor , Pessoa Thaissa D. , Othmen Helga , Kubitza Marion , Osten Larissa , de Vries Uwe , Mair Magdalena M. , Somlo Stefan , Moser Markus , Kunzelmann Karl , Ziegler Christine , Haerteis Silke , Korbmacher Christoph , Witzgall Ralph 
Published: August 2021

ABSTRACT
Mutations in the PKD2 gene cause autosomal-dominant polycystic kidney disease but the physiological role of polycystin-2, the protein product of PKD2, remains elusive. Polycystin-2 belongs to the transient receptor potential (TRP) family of non-selective cation channels. To test the hypothesis that altered ion channel properties of polycystin-2 compromise its putative role in a control circuit controlling lumen formation of renal tubular structures, we generated a mouse model in which we exchanged the pore loop of polycystin-2 with that of the closely related cation channel polycystin-2L1 (encoded by PKD2L1), thereby creating the protein polycystin-2poreL1. Functional characterization of this mutant channel in Xenopus laevis oocytes demonstrated that its electrophysiological properties differed from those of polycystin-2 and instead resembled the properties of polycystin-2L1, in particular regarding its permeability for Ca2+ ions. Homology modeling of the ion translocation pathway of polycystin-2poreL1 argues for a wider pore in polycystin-2poreL1 than in polycystin-2. In Pkd2poreL1 knock-in mice in which the endogenous polycystin-2 protein was replaced by polycystin-2poreL1 the diameter of collecting ducts was increased and collecting duct cysts developed in a strain-dependent fashion.
Sodium Thiosulfate Reduces Acute Kidney Injury in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy with Cisplatin: A Single-Center Observational Study
Authors: Kurreck Annika , Gronau Felix , Alberto Vilchez Miguel Enrique , Abels Wiltrud , Enghard Philipp , Brandl Andreas , Francis Roland , Föhre Bettina , Lojewski Christian , Pratschke Johann , Thuss-Patience Peter , Modest Dominik , Rau Beate , Feldbrügge Linda 
Published: August 2021

Abstract
Background
Cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a multimodal treatment concept for patients with peritoneal surface malignancies. The use of intraperitoneal cisplatin (CDDP) is associated with a risk of acute kidney injury (AKI). The aim of this study is to evaluate the protective effect of perioperative sodium thiosulfate (STS) administration on kidney function in patients undergoing CRS and CDDP-based HIPEC.

Patients and Methods
We retrospectively analyzed clinical data of all patients who underwent CRS and CDDP-based HIPEC at our hospital between March 2017 and August 2020. Patients were stratified according to the use of sodium thiosulfate (STS vs. no STS). We compared kidney function and clinical outcome parameters between both groups and determined risk factors for postoperative AKI on univariate and multivariate analysis. AKI was classified according to acute kidney injury network (AKIN) criteria.

Results
Of 238 patients who underwent CRS and CDDP-based HIPEC, 46 patients received STS and 192 patients did not. There were no significant differences in baseline characteristics. In patients who received STS, a lower incidence (6.5% vs. 30.7%; p = 0.001) and severity of AKI (p = 0.009) were observed. On multivariate analysis, the use of STS (OR 0.089, p = 0.001) remained an independent kidney-protective factor, while arterial hypertension (OR 5.283, p < 0.001) and elevated preoperative urea serum level (OR 5.278, p = 0.032) were predictors for postoperative AKI.

Conclusions
The present data suggest that STS protects patients from AKI caused by CRS and CDDP-based HIPEC. Further prospective studies are needed to validate the benefit of STS among kidney-protective strategies.
Curved Approach in High Jump Induces Greater Jumping Height without Greater Joint Kinetic Exertions than Straight Approach
Authors: SADO NATSUKI , YOSHIOKA SHINSUKE , FUKASHIRO SENSHI 
Published: August 2021

ABSTRACT

Purpose
The most height-specific jumping mode, the athletic high jump, is characterized as a running single-leg jump (RSLJ) from a curved approach. The main advantage of a curved approach is believed to be facilitation of bar clearance. However, the effect of a curved approach on center-of-mass (CoM) height generation has not been clarified. Here, we show that the curved RSLJ (C-RSLJ) is more suitable than the straight RSLJ (S-RSLJ) for CoM height generation.

Methods
We collected data using motion capture from 13 male high jumpers (personal best, 2.02–2.31 m) that performed C-RSLJ and S-RSLJ. We then compared the energy generation contributing to CoM height (E
vert) in each approach.

Results
All participants attained greater CoM height in C-RSLJ than in S-RSLJ (difference, 0.055 ± 0.024 m). Three-dimensional joint kinematics and kinetics were similar between both approaches, except for the ankle plantar-flexion torque, which was smaller in C-RSLJ. The sum of positive work was comparable between the approaches, whereas the sum of negative work in C-RSLJ was significantly smaller than in S-RSLJ. The shank forward rotation induced a larger difference in E
vert generation between C-RSLJ and S-RSLJ (0.80 ± 0.36 J·kg−1) than any other segment (≤0.36 J·kg−1).

Conclusions
Compared with a straight approach, a curved approach induces greater CoM height without increasing joint kinetic exertions during takeoff. The curved approach changes the initial condition of the takeoff and promotes the transformation of horizontal kinetic energy into E
vert. This study provides novel practical perspectives for high jumpers and highlights the importance of segment biomechanics in human motor performance.