bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic Analysis of Quality Innovation in Design and Manufacturing
Authors: Vasseur Hubert , Kurfess Thomas R. , Cagan Jonathan 
Published: March 2021

Abstract
Due to several possible production modes, an industrial output may have different quality levels. Production processes and quality assurance plans are chosen and adjusted, generally as a lagged reaction to customers’ input and competitors’ strategy. Different techniques based on cost benefit analysis have existed to assess beforehand the overall benefits to society of such decisions; however, these techniques do not necessarily provide any insight as to the resulting influence on corporate profits. This paper reviews different perspectives on industrial quality and adopts a formalism in which social and corporate optimum can be compared from an engineering standpoint. The potential benefits for a manufacturer to improve the quality of its products are studied under several market conditions. The incentive is the strongest in a competitive environment where the benefits of quality innovation are twofold: quality innovation increases consumers’ demand and allows the manufacturer to keep more substantial profit margins.
Optimal Heat Sink Design and Component Placement Using the Ellipsoid Method
Authors: Urban Carl T. , Gabriele Gary A. 
Published: March 2021

Abstract
In the electronic products market, intense competition from overseas has made product cost, performance and time-to-market critical factors to a company’s survival. While recent advances in manufacturing methods and material handling systems have aided in this struggle, the decisions made in the early stages of design still control an overwhelming majority of a product’s final cost and delivery schedule. These decisions affect the entire life-cycle of the product from design, through the customer’s use, to disposal.
This paper describes the development of a simple heat sink component placement optimization procedure using the Ellipsoid Algorithm. Two heat sink geometries were modelled to determine their steady state temperature distributions and the component junction temperature(s). By relocating the component(s), the Ellipsoid Algorithm sought to minimize the heat sink assembly’s failure rate. The effect of heat sink size on assembly reliability is also presented. The heat sink thermal model was formulated using finite differences and written in Fortran 77.
Modeling Evolving Product Data for Concurrent Engineering
Authors: Cleetus K. J. 
Published: March 2021

Abstract
In order to make the traditional product structure tree representation amenable to concurrent engineering, relationships like perspective-of and dependent-on have to be added to the essential part-of relationship. Complex data can be held in proprietary formats, while simple data will be in a common representation for direct access by diverse disciplines. Coordination among team members in a project can be carried out using such a model. Besides, a virtually unified view of all the data is possible, though they may lie in distributed and heterogeneous data bases. A very necessary characteristic of such a model is that its time evolution should be easy to represent in order to reflect the dynamic nature of product development, where the model itself, and not merely the data values change. Managing versions is also facilitated by the comprehensive structure of the Unified Product Data Model (UPDM).
Two key switches in regional stress field during multi-stage deformation in the Carboniferous–Triassic southernmost Altaids (Beishan, NW China): Response to orocline-related roll-back processes
Authors: Tian Zhonghua , Xiao Wenjiao , Windley Brian F. , Huang Peng , Zhang Ji’en , Ao Songjian , Zhang Zhiyong , Song Dongfang , Liu Fulai 
Published: March 2021

AbstractThe orogenic architecture of the Altaids of Central Asia was created by multiple large-scale slab roll-back and oroclinal bending. However, no regional structural deformation related to roll-back processes has been described. In this paper, we report a structural study of the Beishan orogenic collage in the southernmost Altaids, which is located in the southern wing of the Tuva-Mongol Orocline. Our new field mapping and structural analysis integrated with an electron backscatter diffraction study, paleontology, U-Pb dating, 39Ar-40Ar dating, together with published isotopic ages enables us to construct a detailed deformation-time sequence: During D1 times many thrusts were propagated northwards. In D2 there was ductile sinistral shearing at 336–326 Ma. In D3 times there was top-to-W/WNW ductile thrusting at 303–289 Ma. Two phases of folding were defined as D4 and D5. Three stages of extensional events (E1–E3) separately occurred during D1–D5. Two switches of the regional stress field were identified in the Carboniferous to Early Permian (D1-E1-D2-D3-E2) and Late Permian to Early Triassic (D4-E3-D5). These two switches in the stress field were associated with formation of bimodal volcanic rocks, and an extensional interarc basin with deposition of Permian-Triassic sediments, which can be related to two stages of roll-back of the subduction zone on the Paleo-Asian oceanic margin. We demonstrate for the first time that two key stress field switches were responses to the formation of the Tuva-Mongol Orocline.
Prevalence of glaucoma in the Lao People’s Democratic Republic: the Vientiane Eye Study
Authors: Guo Brad , Tan Yiran , Nygaard Stephen , Carrillo Cesar , Nouansavanh Kham Od , Souksamone Kitar , Casson Robert J 
Published: March 2021

AimsTo determine the prevalence and subtypes of glaucoma in Vientiane Province.MethodsWe conducted a population-based study of 1264 participants aged ≥40 years of age from urban and rural areas of Vientiane Province. Data collection included Snellen visual acuity, slip lamp examination, tonometry, gonioscopy, dilated stereoscopic disc examination and perimetry. Glaucoma was categorised by clinical subtype.ResultsThe mean age of the 1264 participants was 57.6 years; 91.9% of eyes had a gradable disc. The prevalence of glaucoma of any category in at least one eye was 1.54% (95% CI 0.66% to 3.59%). The overall prevalence of primary open-angle glaucoma, primary angle-closure glaucoma and secondary glaucoma was 0.62% (95% CI 0.19% to 1.98%), 0.55% (95% CI 0.12% to 2.54%) and 0.37% (95% CI 0.07% to 1.86%); 12 (66.7%) of participants with glaucoma were at least unilaterally blinded by WHO definition.ConclusionsThe prevalence of glaucoma in the Vientiane Eye Study is relatively low compared with the prevalence reported in other studies from Asian regions; however, the median age in this study was low, reflecting the age group of the population and the rapid urbanisation occurring in the Lao People’s Democratic Republic. Nevertheless, glaucoma remains a blinding disease in this population.
Predicting the safety zone for steroid-induced ocular hypertension induced by intravitreal dexamethasone implantation
Authors: Choi Wungrak , Bae Hyoung Won , Shin Hye Jung , Kim Eun Woo , Kim Chan Yun , Kim Min , Seong Gong Je 
Published: March 2021

Background/aimsThis study aimed to predict the possibility of steroid-induced ocular hypertension (OHT) after intravitreal dexamethasone (DEX) implantation and to identify a proper safety zone for such injections.MethodsA cross-sectional observational study was conducted and included 908 patient eyes that underwent DEX implant injection due to various retinal diseases. Intraocular pressure (IOP) was measured before injection, at 1 week, and at 1, 2, 3, 6 and 12 months thereafter. Eyes of enrolled patients were divided into the OHT and normal IOP groups. Univariable logistic regression analysis was used to assess significant associations between steroid-induced OHT and covariates; significant and previously reported significant variables were analysed with a multivariable model, and predictive nomograms were developed.ResultsAge, sex, axial length, glaucomatous eye, neovascular glaucoma, secondary glaucoma, uveitis history, hypertension, depression, diabetes mellitus and a history of previous laser-assisted in-situ keratomileusis or laser-assisted subepithelial keratectomy were significantly related to steroid-induced OHT (p<0.05). The calibration plot revealed good prediction under a predicted value of 0.4. Cut-off values for 80%, 86%, 91%, 95% and 98% sensitivity and specificity were offered for the safety zone after intravitreal DEX implantation.ConclusionWe developed two nomograms to predict a safety zone for intravitreal DEX implantation. These can be used to identify individuals who may be safely prescribed steroid treatments and for whom extra caution should be exercised.
ACL reconstruction for all is not cost-effective after acute ACL rupture
Authors: Eggerding Vincent , Reijman Max , Meuffels Duncan Edward , van Es Eline , van Arkel Ewoud , van den Brand Igor , van Linge Joost , Zijl Jacco , Bierma-Zeinstra Sita MA , Koopmanschap Marc 
Published: March 2021

ObjectivesTo conduct a cost-utility analysis for two commonly used treatment strategies for patients after ACL rupture; early ACL reconstruction (index) versus rehabilitation plus an optional reconstruction in case of persistent instability (comparator).MethodsPatients aged between 18 and 65 years of age with a recent ACL rupture (<2 months) were randomised between either an early ACL reconstruction (index) or a rehabilitation plus an optional reconstruction in case of persistent instability (comparator) after 3 months of rehabilitation. A cost-utility analysis was performed to compare both treatments over a 2-year follow-up. Cost-effectiveness was calculated as incremental costs per quality-adjusted life year (QALY) gained, using two perspectives: the healthcare system perspective and societal perspective. The uncertainty for costs and health effects was assessed by means of non-parametric bootstrapping.ResultsA total of 167 patients were included in the study, of which 85 were randomised to the early ACL reconstruction (index) group and 82 to the rehabilitation and optional reconstruction group (comparator). From the healthcare perspective it takes 48 460 € and from a societal perspective 78 179 €, to gain a QALY when performing early surgery compared with rehabilitation plus an optional reconstruction. This is unlikely to be cost-effective.ConclusionRoutine early ACL reconstruction (index) is not considered cost-effective as compared with rehabilitation plus optional reconstruction for a standard ACL population (comparator) given the maximum willingness to pay of 20 000 €/QALY. Early recognition of the patients that have better outcome of early ACL reconstruction might make rehabilitation and optional reconstruction even more cost-effective.
Health wearable devices for weight and BMI reduction in individuals with overweight/obesity and chronic comorbidities: systematic review and network meta-analysis
Authors: McDonough Daniel J , Su Xiwen , Gao Zan 
Published: March 2021

ObjectiveTo analyse the comparative effectiveness of different health wearable-based physical activity (PA) promotion intervention strategies against each other and control for reducing body weight and body mass index (BMI) in individuals with overweight/obesity and chronic comorbidities.DesignSystematic review and network meta-analysis (PROSPERO identifier: CRD42020158191).Data sourcesWe performed two independent searches from December 2019 to September 2020 in PubMed, MEDLINE, Scopus, Web of Science, Central Register of Controlled Trials, EMBASE and PsycINFO databases for articles published in English between 2007 and 2020.Eligibility criteria for selecting studiesInclusion criteria were based on the PICOS framework. We included randomised controlled trials of health wearable-based interventions using two or more PA intervention arms/strategies and compared their effects on participants’ body weight (kg) and BMI (kg/m2) with a control group. Data were analysed using a Bayesian network meta-analysis to directly and indirectly compare the effects of the six different intervention strategies (comparators). The six comparators were: (1) control group (ie, usual care, waitlist); (2) comparison group (ie, traditional, non-health wearable PA interventions); (3) commercial health wearable-only intervention (eg, Fitbit, Polar M400); (4) research grade health wearable-only intervention (ie, accelerometers or pedometers); (5) multicomponent commercial health wearable intervention (eg, Fitbit + nutrition counselling); and (6) multicomponent research grade health wearable intervention. The results were reported as standardised mean differences (SMDs) with associated 95% credible intervals (CrIs).ResultsFrom 641 screened records, 31 studies were included. For body weight reduction in individuals with overweight/obesity and chronic comorbidities, accelerometer/pedometer-only (SMD −4.44, 95% CrI −8.94 to 0.07) and commercial health wearable-only (SMD −2.76, 95% CrI −4.80 to −0.81) intervention strategies were the most effective compared with the three other treatments and control. For BMI reduction, multicomponent accelerometer/pedometer (SMD −3.43, 95% CrI −4.94 to −2.09) and commercial health wearable-only (SMD −1.99, 95% CrI −4.95 to 0.96) intervention strategies were the most effective compared with the other four conditions.ConclusionHealth wearable devices are effective intervention tools/strategies for reducing body weight and BMI in individuals with overweight/obesity and chronic comorbidities.
Global and regional levels and trends of child and adolescent morbidity from 2000 to 2016: an analysis of years lost due to disability (YLDs)
Authors: Guthold Regina , White Johansson Emily , Mathers Colin Douglas , Ross David A 
Published: March 2021

IntroductionNon-fatal health loss makes a substantial contribution to the total disease burden among children and adolescents. An analysis of these morbidity patterns is essential to plan interventions that improve the health and well-being of children and adolescents. Our objective was to describe current levels and trends in the non-fatal disease burden from 2000 to 2016 among children and adolescents aged 0–19 years.MethodsWe used years lost due to disability (YLD) estimates in WHO’s Global Health Estimates to describe the non-fatal disease burden from 2000 to 2016 for the age groups 0–27 days, 28 days–11 months, 1–4 years, 5–9 years, 10–14 years and 15–19 years globally and by modified WHO region. To describe causes of YLDs, we used 18 broad cause groups and 54 specific cause categories.ResultsIn 2016, the total number of YLDs globally among those aged 0–19 years was about 130 million, or 51 per 1000 population, ranging from 30 among neonates aged 0–27 days to 67 among older adolescents aged 15–19 years. Global progress since 2000 in reducing the non-fatal disease burden has been limited (53 per 1000 in 2000 for children and adolescents aged 0–19 years). The most important causes of YLDs included iron-deficiency anaemia and skin diseases for both sexes, across age groups and regions. For young children under 5 years of age, congenital anomalies, protein–energy malnutrition and diarrhoeal diseases were important causes of YLDs, while childhood behavioural disorders, asthma, anxiety disorders and depressive disorders were important causes for older children and adolescents. We found important variations between sexes and between regions, particularly among adolescents, that need to be addressed context-specifically.ConclusionThe disappointingly slow progress in reducing the global non-fatal disease burden among children and adolescents contrasts starkly with the major reductions in mortality over the first 17 years of this century. More effective action is needed to reduce the non-fatal disease burden among children and adolescents, with interventions tailored for each age group, sex and world region.
Plasma cell marker, immunoglobulin J polypeptide, predicts early disease-specific mortality in HPV+ HNSCC
Authors: Gui Shanying , O'Neill W Quinn , Teknos Theodoros N , Pan Quintin 
Published: March 2021

BackgroundPatients with human papillomavirus (HPV+) head and neck squamous cell carcinoma (HNSCC) have superior prognoses compared with patients with HPV− HNSCC and strategies for treatment de-escalation are under investigation for the HPV+ setting. However, the survival advantage associated with HPV is not universal, and a subset of patients with HPV+ HNSCC fail definitive treatment and progress with metastatic/recurrent disease. Currently, no biomarker is available to distinguish aggressive from indolent HPV+ HNSCC. Immune dysfunction facilitates tumorigenesis and is associated with poor treatment response; therefore, we hypothesized that diminished intratumoral immune cell functionality may be attractive biomarkers to identify patients with HPV+ HNSCC at risk for early disease-specific mortality.MethodsThis is a retrospective analysis of The Cancer Genome Atlas (TCGA) HPV+ HNSCC cohort.ResultsImmunoglobulin J polypeptide (IGJ), uniquely expressed in plasma cells, showed a broad expression range in HPV+ HNSCC. Cox regression model, adjusting for clinical covariates, indicated that IGJ is an independent prognostic biomarker for disease-specific survival (DSS) and overall survival (OS). Patients with low IGJ had a 7.2-fold (p<0.001) increase in risk of disease-specific death with a median DSS of 13 months. Low IGJ showed an area under curve (AUC) of 0.89 with 91.0% sensitivity and 87.6% specificity to identify early disease-specific mortality (defined as DSS ≤12 months). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed a global dampening of immune pathways in low IGJ tumors.ConclusionsOur work showed that IGJ is a robust and independent prognostic biomarker for disease-specific mortality in HPV+ HNSCC. Patient with HPV+ HNSCC with limited adaptive immune functionality should not be candidates for treatment de-escalation modalities.
Occupational physical activity and cardiovascular disease in the United States
Authors: Quinn Tyler D. , Yorio Patrick L. , Smith Peter M. , Seo Yongsuk , Whitfield Geoffrey P. , Barone Gibbs Bethany 
Published: March 2021

BackgroundEmerging evidence, predominately from European and Asian countries, describes opposing effects of occupational physical activity (OPA) and leisure-time physical activity (LTPA) on cardiovascular health. This analysis examined cardiovascular disease (CVD) prevalence associated with OPA and LTPA.MethodsThis cross-sectional analysis of 2015 National Health Interview Survey data (n=16 974) employed logistic regression to estimate odds (OR) of self-reported CVD (coronary heart disease, heart attack, stroke or angina) with self-reported total occupational activity (TOA), occupational exertion (OE), occupational standing and walking (OSW) and LTPA. OPA was measured using two questions: ‘How often does your job involve…’ (1) ‘repeated lifting, pushing, pulling or bending?’ (OE) and (2) ‘standing or walking around?’ (OSW) with responses on a 5-item Likert scale (0=never, 4=always). TOA was categorised similarly after summing OE and OSW scores. LTPA was defined as 0, 1–149 or ≥150 min/week of moderate-to-vigorous activity. All models adjusted for common socioeconomic variables and additional analyses were stratified by sex, smoking status and LTPA.ResultsOdds for CVD were higher when ‘always’ performing TOA (OR 1.99 95% CI 1.12 to 3.53), OE (OR 2.15, 95% CI 1.45 to 3.19) or OSW (OR 1.84, 95% CI 1.07 to 3.17) compared with ‘never’. When restricting to never-smokers, odds for CVD were higher when ‘always’ performing TOA (OR 3.00, 95% CI 1.38 to 6.51) and OE (OR 3.00, 95% CI 1.80 to 5.02) versus ‘never’.ConclusionAssociations of high OPA with CVD were equally apparent across sexes, stronger in lower LTPA levels and stronger in never-smokers. While uncontrolled confounding is still possible, even after extensive adjustment, the seemingly paradoxical adverse associations with OPA and CVD should be investigated further.
Does gradually returning to work improve time to sustainable work after a work-acquired musculoskeletal disorder in British Columbia, Canada? A matched cohort effectiveness study
Authors: Maas Esther T , Koehoorn Mieke , McLeod Christopher B 
Published: March 2021

ObjectiveThis study investigates if gradual return to work (GRTW) is associated with full sustainable return to work (RTW) for seriously injured workers with a musculoskeletal disorder (MSD), in British Columbia, Canada.MethodsThis is an effectiveness study using a retrospective cohort study design. Accepted workers’ compensation lost-time claims were extracted for workers with an MSD who were on full work disability for at least 30 days, between 2010 and 2015 (n=37 356). Coarsened exact matching yielded a final matched cohort of 12 494 workers who experienced GRTW at any point 30 days post-injury and 12 494 workers without any GRTW. The association between GRTW and sustainable RTW through to end of 12 months was estimated with multivariable quantile regression.ResultsWorkers who were provided with GRTW experienced more time-loss days until sustainable RTW between the 2nd and 5th months after the first time-loss day (<50th quantile of time loss), but less time-loss days until sustainable RTW between the 6th and 12th months of work disability (70th quantile of time loss), with the largest effect for women, workers with soft-tissue injuries and workers in the manufacturing or trades sector (all in the 60th and 70th percentile, after 6–7 months of time loss).ConclusionsFor seriously injured workers with at least 30 days of disability due to a work-acquired MSD, the effect of GRTW becomes apparent at longer disability durations (more than 6 months), with larger beneficial effects for women, workers with soft-tissue injuries and for trade and manufacturing sectors.
Neurological outcomes of untreated brainstem cavernous malformations in a prospective observational cohort and literature review
Authors: Li Da , Zheng Jing-Jie , Weng Jian-Cong , Liu Pan-Pan , Wu Ze-Yu , Zhang Li-Wei , Zhang Jun-Ting , Wang Liang , Wu Zhen 
Published: March 2021

BackgroundHaemorrhages of brainstem cavernous malformations (CMs) can lead to neurological deficits, the natural history of which is uncertain. The study aimed to evaluate the neurological outcomes of untreated brainstem CMs and to identify the adverse factors associated with worsened outcomes.MethodsFrom 2009 to 2015, 698 patients (321 women) with brainstem CMs were entered into the prospective cohort after excluding patients lost to follow-up (n=43). All patients were registered, clinical data were collected and scheduled follow-up was performed.ResultsAfter a median follow-up of 60.9 months, prospective haemorrhages occurred in 167 patients (23.9%). The mean modified Rankin Scale scores at enrolment and at censoring time were 1.6 and 1.2. Neurological status was improved, unchanged and worsened in 334 (47.9%), 293 (42.0%) and 71 (10.2%) patients, respectively; 233 (33.4%) recovered to normal levels. Lesions crossing the axial midpoint (relative risk (RR) 2.325, p=0.003) and developmental venous anomaly (DVA) (RR 1.776, p=0.036) were independently significantly related to worsened outcomes. The percentage of worsened outcomes was 5.3% (18 of 337) in low-risk patients (neither DVA nor crossing the axial point) and increased to 26.0% (13 of 50) in high-risk patients (with both DVA and crossing the axial point). The percentage of worsened outcomes significantly increased as the number of prospective haemorrhages increased (from 1.5% (8 of 531, if 0 prospective ictus) to 37.5% (48 of 128, if 1 ictus) and 38.5% (15 of 39, if >1 ictus)).ConclusionsThe neurological outcomes of untreated brainstem CMs were improved/unchanged in majority of patients (89.8%) with a fatality rate of 1.7% in our cohort, which seemed to be favourable. Radiological features significantly predicted worsened outcomes. Our results provide evidence for clinical consultation and individualised treatment. The referral bias of our cohort was underlined.