bluuebunny/crossref_metadata_2025_split huggingface dataset:
DeeReCT-TSS: A novel meta-learning-based method annotates TSS in multiple cell types based on DNA sequences and RNA-seq data
Authors: Zhou Juexiao , Zhang Bin , Li Haoyang , Zhou Longxi , Li Zhongxiao , Long Yongkang , Han Wenkai , Wang Mengran , Cui Huanhuan , Chen Wei , Gao Xin 
Published: July 2021

AbstractThe accurate annotation of transcription start sites (TSSs) and their usage is critical for the mechanistic understanding of gene regulation under different biological contexts. To fulfill this, on one hand, specific high-throughput experimental technologies have been developed to capture TSSs in a genome-wide manner. On the other hand, various computational tools have also been developed for in silico prediction of TSSs solely based on genomic sequences. Most of these computational tools cast the problem as a binary classification task on a balanced dataset and thus result in drastic false positive predictions when applied on the genome-scale. To address these issues, we present DeeReCT-TSS, a deep-learning-based method that is capable of TSSs identification across the whole genome based on both DNA sequences and conventional RNA-seq data. We show that by effectively incorporating these two sources of information, DeeReCT-TSS significantly outperforms other solely sequence-based methods on the precise annotation of TSSs used in different cell types. Furthermore, we develop a meta-learning-based extension for simultaneous transcription start site (TSS) annotation on 10 cell types, which enables the identification of cell-type-specific TSS. Finally, we demonstrate the high precision of DeeReCT-TSS on two independent datasets from the ENCODE project by correlating our predicted TSSs with experimentally defined TSS chromatin states. Our application, pre-trained models and data are available at https://github.com/JoshuaChou2018/DeeReCT-TSS_release.
A conditioned place preference for heroin is signaled by increased dopamine and direct pathway activity and decreased indirect pathway activity in the nucleus accumbens
Authors: O’Neal Timothy J. , Bernstein Mollie X. , MacDougall Derek J. , Ferguson Susan M. 
Published: July 2021

ABSTRACTInitial drug use promotes the development of conditioned reinforcement, whereby the reinforcing properties of a drug become attributed to drug-associated stimuli, such as cues and contexts. A principal role for the nucleus accumbens (NAc) in the response to drug-associated stimuli has been well-documented. In particular, direct and indirect pathway medium spiny neurons (dMSNs and iMSNs) have been shown to bidirectionally regulate cue-induced heroin-seeking in rats expressing addiction-like phenotypes, and a shift in NAc activity towards the direct pathway has been shown in mice following cocaine conditioned place preference (CPP). However, how NAc signaling guides heroin CPP, and whether heroin alters the balance of signaling between dMSNs and iMSNs remains unknown. Moreover, the role of NAc dopamine signaling in heroin reinforcement remains unclear. Here, we integrate fiber photometry for in vivo monitoring of dopamine and dMSN/iMSN calcium activity with a heroin CPP procedure in rats to address these outstanding questions. We identify a sensitization-like response to heroin in the NAc, with prominent iMSN activity during initial heroin exposure and prominent dMSN activity following repeated heroin exposure. We demonstrate a ramp in dopamine activity, dMSN activation, and iMSN inactivation preceding entry into a heroin-paired context, and a decrease in dopamine activity, dMSN inactivation, and iMSN activation preceding exit from a heroin-paired context. Finally, we show that buprenorphine is sufficient to prevent the development of heroin CPP and activation of the NAc post-conditioning. Together, these data support the hypothesis that an imbalance in NAc activity contributes to the development of addiction.SIGNIFICANCE STATEMENTThe attribution of the reinforcing effects of drugs to neutral stimuli (e.g., cues and contexts) contributes to the maintenance of addiction, as re-exposure to drug-associated stimuli can reinstate drug seeking and taking even after long periods of abstinence. The nucleus accumbens (NAc) has an established role in encoding the value of drug-associated stimuli, and dopamine release into the NAc is known to modulate the reinforcing effects of drugs, including heroin. Using fiber photometry, we show that entering a heroin-paired context is driven by dopamine signaling and NAc direct pathway activation, whereas exiting a heroin-paired context is driven by NAc indirect pathway activation. This study provides further insight into the role of NAc microcircuitry in encoding the reinforcing properties of heroin.
The impact of debt service costs and public debt on private capital formation in South Africa
Authors: Zhou Sheunesu 
Published: July 2021

PurposeThe aim of this paper is to analyse the relationship between public debt, corporate debt service costs and private capital formation in South Africa.Design/methodology/approachTo capture the long-run characteristic of investment, the study adopts the Fully Modified Ordinary Least Squares approach and tests for cointegration using Hansen (1992)'s Parameter Instability test.FindingsWe find that private capital formation increases in domestic debt and decreases in external debt during the pre-crisis period. However, during the period post the Global Financial Crisis, we find evidence of domestic public debt crowding out private capital formation, whereas external debt crowds-in capital formation. Debt service costs are found to reduce investment due to the effect of the debt overhang throughout the period under analysis.Research limitations/implicationsThe paper has important implications for macroeconomic policy. In particular, there is need for deleveraging and allocation of a higher proportion of debt to public infrastructure expenditure which has complementary effects on private investment.Practical implicationsDebt overhang signal that South African firms could be over-leveraged, which hinders future growth prospects. Firms that face high levels of debt should consider debt restructuring.Originality/valueEmpirical studies undertaken to explore this relationship have yielded contradicting results suggesting that the relationship between public debt and private investment is heterogeneous depending on a given economy or prevailing macroeconomic environment. In particular, existing research does not provide evidence on whether recent increases in public debt in South Africa have led to crowding-in or crowding-out of private investment. This paper therefore contributes to empirical literature on the impact of public debt on private investment within a small open economy.
Women on boards of directors: the moderation role of female labour force participation
Authors: Hamdan Reem , Hamdan Allam , Alareeni Bahaaeddin , Atayah Osama F. , Alhalwachi Layla Faisal 
Published: July 2021

Purpose
This study aims to investigate the moderation role of the percentage of women in the country labour force in the relationship between firm-level governance factors (board size, institutional ownership, ownership concentration, board independence, performance, firm size, firm’s risk and sector) and women on boards (WOBs) in publicly listed firms in Gulf Cooperation Council (GCC) countries.

Design/methodology/approach
The study relied on a sample of 436 publicly listed firms in 2018 in six GCC countries (Bahrain, Kuwait, Saudi Arabia, Oman, Qatar and the United Arab Emirates).

Findings
The study concluded that the percentage of women in the country’s labour force has a moderation role in the relationship between board size and WOB, as well as firm market performance and WOBs. However, ownership concentration, firm size, firm risk and firm sector do not affect the percentage of WOB; consequently, the percentage of women in the country’s labour force did not have a moderation role in the relationship between these variables and the percentage of WOBs.

Originality/value
The study incorporates an institutional level variable which is the percentage of women in the country’s labour force in a firm-level relationship mostly understood by agency theory.
A stakeholder analysis of government policy intervention in the Ghanaian slum communities
Authors: Nkrumah Agyabeng Anthony , Preko Alexander 
Published: July 2021

Purpose
Slum upgrading has received intense attention in the Global South, particularly among stakeholders. This study aims to examine government policy priorities towards slum management with the view of establishing its level of commitment in terms of measures undertaken and identify specific policies to structure the sector.

Design/methodology/approach
The study systematically reviewed national policies, guided by the frequency statistics method in identifying key issues relating to slums management. Content analysis was used to identify findings into themes and discussed in line with the study’s objectives.

Findings
The results revealed the government’s determination to upgrade the existing slums, with the establishment of a Ministry for Inner City and Zongo Development to facilitate collaboration between stakeholders in the value chain of slum management. Furthermore, the study established government’s resolve to strengthen the Local Government Act, 1993, and the National Development Planning Act, 1994 within context to pave way for slums upgrading.

Research limitations/implications
The study used a national policy framework to inform the conclusion reached. Further studies are needed in similar contexts to understand the inputs of government and stakeholders and their contributions towards slum management. This would further expand the frontiers of knowledge in the domain.

Practical implications
The findings revealed policy-driven that can be used by policymakers, practitioners, housing managers and other relevant stakeholders to create workable policies for slum management.

Originality/value
This study provides first insight into government commitment to slums management using national policy documents in context.
Impact of urbanization on per capita energy use and emissions in India
Authors: Haldar Stuti , Sharma Gautam 
Published: July 2021

Purpose
The purpose of this study is to investigate the impacts of urbanization on per capita energy consumption and emissions in India.

Design/methodology/approach
The present study analyses the effects of urbanization on energy consumption patterns by using the Stochastic Impacts by Regression on Population, Affluence and Technology in India. Time series data from the period of 1960 to 2015 has been considered for the analysis. Variables including Population, GDP per capita, Energy intensity, share of industry in GDP, share of Services in GDP, total energy use and urbanization from World Bank data sources have been used for investigating the relationship between urbanization, affluence and energy use.

Findings
Energy demand is positively related to affluence (economic growth). Further the results of the analysis also suggest that, as urbanization, GDP and population are bound to increase in the future, consequently resulting in increased carbon dioxide emissions caused by increased energy demand and consumption. Thus, reducing the energy intensity is key to energy security and lower carbon dioxide emissions for India.

Research limitations/implications
The study will have important policy implications for India’s energy sector transition toward non- conventional, clean energy sources in the wake of growing share of its population residing in urban spaces.

Originality/value
There are limited number of studies considering the impacts of population density on per capita energy use. So this study also contributes methodologically by establishing per capita energy use as a function of population density and technology (i.e. growth rates of industrial and service sector).
Governance and renewable energy consumption in Sub-Saharan Africa
Authors: Asongu Simplice , Odhiambo Nicholas M. 
Published: July 2021

Purpose
The purpose of this study is to assess the nexus between governance and renewable energy consumption in Sub-Saharan Africa (SSA).

Design/methodology/approach
The focus is on 44 countries in SSA with data from 1996 to 2016. The empirical evidence is based on Tobit regressions.

Findings
It is apparent from the findings that political and institutional governance are negatively related to the consumption of renewable energy in the sampled countries. The unexpected findings are clarified and policy implications are discussed in the light of sustainable development goals.

Originality/value
This study extends the extant literature by assessing how political governance (consisting of political stability and “voice and accountability”) and institutional governance (entailing the rule of law and corruption-control) affect the consumption of renewable energy in SSA.
A self-congruence and impulse buying effect on user’s shopping behaviour over social networking sites: an empirical study
Authors: Chauhan Shaifali , Banerjee Richa , Chakraborty Chinmay , Mittal Mohit , Shiva Atul , Ravi Vinayakumar 
Published: July 2021

PurposeThis study aims to investigate the shopping behaviour of consumers, mainly in fashion apparels, and intends to understand consumer buying patterns in Indian context. The study was designed to determine the level of consumer's sense of belonging towards apparel shopping by applying the concept of self-congruence.Design/methodology/approachThe study used variance-based partial least squares structural equational modelling (PLS-SEM) on a cross-sectional study conducted on 569 consumers. The study was conducted by using questionnaire to collect the responses from the central zone of India. The results support most of the projected hypotheses.FindingsThe study focused on the shopping behaviour of consumer such as self-congruence, impulse buying, hedonic values and consumer satisfaction. The results of the study highlight the association of constructs and analysed the mediation relation of hedonic and impulse buying constructs. The results revealed a positive association among the constructs and also found a partial mediation effect in their relation with constructs.Research limitations/implicationsThe findings are outcomes of an empirical study conducted in the fashion apparel industry of India based on the sample set of urban consumers. The study is restricted to the direct and indirect relationship of constructs. Further, research can examine by using moderating constructs like demographic factors (gender, age, income, etc.) and other shopping behaviours (like brand loyalty, brand love, brand attachment) for more clarity in results. Moreover, the study limited is with fashion apparel, whereas there are many categories in the fashion industry like accessories, perfumes, cosmetic products, footwear and also other products industry.Practical implicationsThe study provided valuable inputs to the literature of marketing where self-congruence affects consumer shopping behaviour such as impulse buying, hedonic values and consumer satisfaction. The study proposes a practical approach that can help the marketing professionals and product developers to have a deep understanding about consumer shopping behaviour for facilitating consumer-oriented goods in the Indian fashion industry.Originality/valueThis is one of the first studies in the fashion industry to test the association of self-congruence with hedonic value and consumer satisfaction. This relation is not tested in context of fashion apparel. Additionally, this study also examined the mediating effect of hedonic value and impulse buying in relation with self-congruence and consumer satisfaction in the Indian context.
Working capital allocations and productivity: empirical issues and role of asset utilization
Authors: Chauhan Gaurav Singh 
Published: July 2021

PurposeThe article highlights potential mismeasurement in working capital allocations among academicians and practitioners and revisits the relationship between firms' working capital and productivity, as evident from their values.Design/methodology/approachThe research design acknowledges the relative role of firms' working capital vis-a-vis other assets in generating revenue, thereby effectively accounting for the overall asset efficiency in influencing firm value. The authors use a multivariate framework to draw inferences from the marginal impact of working capital and its components on firm value while controlling for asset utilization.FindingsThe authors find that, after accounting for asset utilization, the marginal impact of working capital and its components on firm value is quite weak. The results are consistent with the hypothesis that firms' trade-off between short-term and long-term assets per se should not have any value implications. After controlling for their asset turnovers, the authors find that higher allocations to working capital relative to other assets are not necessarily value-destructive. The findings contrast with the past literature.Research limitations/implicationsThe article, through its analytical and empirical insights, suggests that working capital allocations should be measured by managers and academicians relative to firms' other asset rather than their sales. Firm values should, therefore, be compared based on firms' overall asset utilization rather than inter-temporal allocations to short-term versus long-term assets.Originality/valueContrary to the existing literature so far, the article explicitly acknowledges the relative role of firms' other assets, and hence the overall asset utilization, to infer the marginal impact of working capital on firm value.
Blockchain adoption in health market: a systems thinking and modelling approach
Authors: Nanda Shweta , Nanda Saket 
Published: July 2021

Purpose
The purpose of this paper is to formulate strategic interventions that can contribute to adoption of blockchain in Asian health market.

Design/methodology/approach
A methodological framework based on the three qualitative phases of the systems thinking and modelling methodology, namely, problem structuring, causal loop modelling and developing strategic interventions were used. Data was collected using thirty interviews and secondary research.

Findings
The reference model developed in the study captured the system behavior, showing health market blockchain adoption increasing in other countries but struggling in Asia. The qualitative systems model developed explained this behavior by capturing the underlying system structure using six interconnected feedback loops. Three strategic interventions were formulated to change the system structure to improve its adoption.

Research limitations/implications
This study acknowledges its limitation that blockchain integration in health supply chain management (SCM) and adaptability to technological trends are just few elements that contributes to challenges in blockchain adoption in Asia Pacific health market . It also acknowledges the limited scale of this study using 30 interviews with a narrow set of stakeholders, limiting its generalisability.

Practical implications
Although the blockchain technology has medical data security benefits, its integration in health SCM could potentially improve cost of health service delivery to patient. Not only it prevents drug counterfeiting, it enhances patient’s safety by reducing the time it takes to alert the supply chain of a product recall from few days to few seconds.

Social implications
“Blockchain-as-a-Service” has wide applications in SCM, identity management, payments, smart contracts, governance risk and compliance management, with its market size expected to grow in future. This affordable solution opens up the roads for future empirical research for information systems academicians and information technology practitioners.

Originality/value
This research provides a holistic analysis of the challenges facing blockchain adoption in the health market for Asia. It offers a methodological approach based on systems thinking and modelling to improve its adoption.
Rural revitalization: sustainable strategy for the development of cultural landscape of traditional villages through optimized IPA approach
Authors: Zhang Qunsong , Kim Eunyoung , Yang Cuixia , Cao Fucun 
Published: July 2021

PurposeThe main purpose of this study is to provide a decision-making basis for the development of a sustainability strategy by importance-performance analysis (IPA) methods. However, traditional and modified IPA methods do not accurately reveal the impact of the various dimensions of sustainable development (SD) on cultural landscape (CL). Based on the structural equation model (SEM), four main dimensions of SD were identified from the available data. This paper conducted an optimized IPA by building three SEMs based on importance, performance and the importance of four dimensions.Design/methodology/approachThis paper proposes the use of exploratory factor analysis (EFA) and SEM to develop the CL characteristic index evaluation model to determine the load of each indicator of importance and performance, and the SD-based measurement model to further determine the weight of the sustainability of each indicator in importance and performance. Afterwards, proposed sustainable strategies to the corresponding index were obtained.FindingsThis study offers useful insights into the actual operation and theoretical aspects of the IPA method.Practical implicationsThis study offers useful insights into the actual operation and theoretical aspects of the IPA method. This can solve the incongruous and uncertainty problem in the sustainable planning strategy, and the case study proves the feasibility of the IPA method combined with the influence of the structural equation.Social implicationsThe research is conducive to acceptance by local people with regard to their preferences in the perspective of sustainable development. It provides a basis for the future use of the IPA method in a comprehensive way based on an administrative angle.Originality/valueThe case study proves the feasibility of the IPA method combined with the influence of the structural equation. This provides a basis for the future use of the IPA method in a comprehensive way based on an administrative angle.