bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying knowledge, social concern and perceived risk in planned behavior theory for tourism in the Covid-19 pandemic
Authors: Rahmafitria Fitri , Suryadi Karim , Oktadiana Hera , Putro Heru Purboyo H. , Rosyidie Arief 
Published: June 2021

Purpose
The paper aims to examine the effect of physical distancing control on the intention to travel during the pandemic and to assess the influence of knowledge, social concern and perceived risk on the theory of planned behavior (TPB).

Design/methodology/approach
A total of 1,068 Indonesian respondents through a purposive sampling approach, filled out online questionnaires during the pandemic. The collected data were analyzed using partial least squares-structural equation modeling.

Findings
The results indicated that subjective norm as the external factor of the TPB has a stronger effect than the internal factors; attitude and behavioral control. It appears that in a collectivist society, prohibition enforced by family and friends, as well as the government’s sanctions have a stronger influence on one’s decision to travel. The findings also suggested that knowledge, perceived risks and social concern effect tourists’ behavior. Uncertainty and inadequate knowledge will decrease the level of perceived risk, which leads to lower control in practicing physical distancing and increasing intention to travel during the pandemic.

Research limitations/implications
The research has limitations in its use of a convenient sampling method. This method may not represent the whole population, causing the results to be difficult for generalization. There is also the need for extending the TPB model with different variables in the context of tourism and pandemic. This study enriches the existing tourism literature by applying TPB to examine tourists’ behavior during the Covid-19 pandemic, focusing on knowledge, social concern and perceived risk theory.

Practical implications
This paper offers useful insights for tourism planners in the government and private destination management levels. It is crucial for a destination management organization to understand the relationship between knowledge, perception and social concern with tourists’ behavior while traveling during pandemics. The understanding of tourist’s behavior when traveling during the pandemic will assist in developing and creating activities and designing health protocols at tourist attractions.

Originality/value
This study extended the TPB to analyze tourists behavior during the pandemic by applying knowledge, social concern and perceived risk elements.
Legal Perception and Finance: The Case of IPO Firm Value
Authors: Schnyder Gerhard , Grosman Anna , Fu Kun , Siems Mathias , Aguilera Ruth V. 
Published: June 2021

AbstractIn this paper, we contribute to the literature on institutional determinants of IPO valuation. We introduce the concept of ‘legal signalling’, which focuses on the perception of the quality of law and thus complements the existing institutional approaches to IPO valuation which consider the quality of the positive law (‘standard view’) and firm‐level corporate governance practices (‘firm signalling view’). Our approach explicitly models the difference between the effect of the positive law and the effect of the perception of law on IPO value. Based on a worldwide longitudinal dataset of IPO performance across a large number of countries, we find strong support for the claim that the perception of the quality of law is more important than its actual quality to explain post‐IPO firm value. This effect holds regardless of whether the law's quality is correctly perceived or misperceived. Overall, our findings underscore the need for a more sophisticated theorization of the ways in which law affects entrepreneurial finance.
Does assortative mating contribute to reproductive isolation among sympatric ecotypes of the wing‐dimorphic stonefly Zelandoperla fenestrata (Plecoptera: Gripopterygidae)?
Authors: Kroos Gracie C , Waters Jonathan M , McCulloch Graham A 
Published: June 2021

AbstractTesting for reproductive isolation among sympatrically diverging lineages is a key prerequisite for understanding speciation processes. Recent genome‐wide studies of the wing‐dimorphic New Zealand stonefly Zelandoperla fenestrata have revealed evidence for ecological speciation among sympatric ecotype pairs, but the basis for their apparent reproductive isolation remains unclear. We conduct paired mating tests among co‐distributed Z. fenestrata ecotypes from southern South Island to test for prezygotic barriers contributing to their reproductive isolation and divergence. Experimental data reveal assortative mating among ecotypes, with strong differentiation in the duration of matings between matched‐ecotype pairs relative to non‐matched pairs. These findings add weight to the hypothesis that assortative mating can be a key mechanism facilitating rapid ecological speciation of sympatric ecotypes. Our study also represents the first documentation of mating behaviours in the Southern Hemisphere stonefly suborder Antarctoperlaria.
Health professional perspectives on an antenatal mental health screening program in a private hospital
Authors: Kohlhoff Jane , Cibralic Sara , Tooke Sarah , Hickinbotham Rachael , Knox Catherine , Roach Vijay , Barnett Bryanne 
Published: June 2021

BackgroundPerinatal mental ill‐health is a global health priority. Mental health screening during pregnancy is a routine part of clinical practice in many public hospital obstetric services across Australia, but implementation in the private hospital system has lagged.AimsThis study explored health professionals’ perspectives on the Pre‐admission Midwife Appointment Program (PMAP), an antenatal mental health screening program at the Mater Hospital, Sydney.Materials and MethodsNine midwives and three medical specialists participated in focus groups or individual interviews; key themes were determined using thematic qualitative analysis.ResultsFive major themes and three sub‐themes were identified: immediate benefits to women (identifying women at risk; referrals to support services; supporting and educating women); enhanced overall quality of care at the hospital; the dilemma of partners attending; factors that make the program successful; and recommendations for improvement.ConclusionsResults will inform the implementation of antenatal mental health screening programs at other private hospitals across Australia.
Dentoalveolar outcomes in maxillary reconstruction: A retrospective review of 85 maxillectomy reconstructions
Authors: Petrides George A. , Hicks Gabrielle , Dunn Masako , Froggatt Catriona , Wallace Christine , Howes Dale , Leinkram David , Low Tsu‐Hui (Hubert) , Ch'ng Sydney , Wykes James , Palme Carsten E. , Clark Jonathan R. 
Published: June 2021

AbstractBackgroundAlthough microvascular free flaps are often used to reconstruct maxillary defects, dentoalveolar rehabilitation is arguably less common despite its importance to midface function and aesthetics. The aim of this study is to review the contemporary management of maxillary defects in a single quaternary referral institution to identify factors that assist or impede dentoalveolar rehabilitation.MethodsA retrospective review of maxillary reconstructions performed between February 2017 and December 2020 was performed. Patient characteristics, defect classification, operative techniques, complications and dentoalveolar outcomes were recorded.ResultsA total of 85 maxillary reconstructions were performed in 73 patients. Of the 64 patients where dental rehabilitation was required, 31 received a functional denture (48%) with 24 (38%) being implant‐retained. Significant predictors of successful rehabilitation included the use of virtual surgical planning (VSP; 86% vs. 25%, p < 0.001), preoperative prosthodontic assessment (82% vs. 21%, p < 0.001), prefabrication (100% vs. 40%, p = 0.002) and use of the zygomatic implant perforator flap technique (100% vs. 39%, p = 0.001). Preoperative prosthodontic consultation was associated with 21‐fold increase in the odds of rehabilitation (odds ratio 20.9, 95% confidence interval 6.54–66.66, p < 0.005).ConclusionPreoperative prosthodontic evaluation, VSP and reconstructive techniques developed to facilitate implant placement are associated with increased dental rehabilitation rates. Despite using an institutional algorithm, functional dentures are frequently prevented by factors including soft tissue constraints, disease recurrence and patient motivation.
Executive cues of organizational virtue and market performance: Creating value during times of earnings uncertainty
Authors: Jancenelle Vivien E. 
Published: June 2021

AbstractThis study investigates whether cues of organizational virtue (conscientiousness, courage, empathy, integrity, warmth, and zeal) sent by top managers can create market value in the context of post‐earnings announcement conference calls and earnings uncertainty. We contend that executive cues of organizational virtue embedded within earnings conference calls can mitigate shareholders' reactions to earnings surprises and use textual analysis to test for the effect of organizational virtue cues on market performance in a longitudinal sample of 1920 firm‐quarter observations. The results suggest that cues of conscientiousness, courage, and zeal are capable of adding back firm value after the posting of earnings surprises, while empathy worsens the market's reaction to earnings surprises. Integrity and warmth were not found to have an effect.
Incidence and impact of community respiratory viral infections in post‐transplant cyclophosphamide‐based graft‐versus‐host disease prophylaxis and haploidentical stem cell transplantation
Authors: Mulroney Carolyn M. , Abid Muhammad Bilal , Bashey Asad , Chemaly Roy F. , Ciurea Stefan O. , Chen Min , Dandoy Christopher E. , Diaz Perez Miguel A. , Friend Brian D. , Fuchs Ephraim , Ganguly Siddhartha , Goldsmith Scott R. , Kanakry Christopher G. , Kim Soyoung , Komanduri Krishna V. , Krem Maxwell M. , Lazarus Hillard M. , Ljungman Per , Maziarz Richard , Nishihori Taiga , Patel Sagar S. , Perales Miguel‐Angel , Romee Rizwan , Singh Anurag K. , Reid Wingard John , Yared Jean , Riches Marcie , Taplitz Randy 
Published: June 2021

SummaryCommunity respiratory viral infections (CRVIs) are associated with pulmonary function impairment, alloimmune lung syndromes and inferior survival in human leucocyte antigen (HLA)‐matched allogeneic haematopoietic stem cell transplant (HCT) recipients. Although the incidence of viral infections in HLA‐haploidentical HCT recipients who receive post‐transplant cyclophosphamide (PTCy)‐based graft‐versus‐host disease (GVHD) prophylaxis is reportedly increased, there are insufficient data describing the incidence of CRVIs and the impact of donor source and PTCy on transplant outcomes. Analysing patients receiving their first HCT between 2012 and 2017 for acute myeloid leukaemia, acute lymphoblastic leukaemia and myelodysplastic syndromes, we describe comparative outcomes between matched sibling transplants receiving either calcineurin‐based GVHD prophylaxis (SibCNI, N = 1605) or PTCy (SibCy, N = 403), and related haploidentical transplants receiving PTCy (HaploCy, N = 757). The incidence of CRVIs was higher for patients receiving PTCy, regardless of donor type. Patients in the HaploCy cohort who developed a CRVI by day +180 had both a higher risk of treatment‐related mortality [hazard ratio (HR) 2⋅14, 99% confidence interval (CI) 1⋅13–4⋅07; P = 0⋅002] and inferior 2‐year overall survival (HR 1⋅65, 99% CI 1⋅11–2⋅43; P = 0⋅001) compared to SibCNI with no CRVI. This finding justifies further research into long‐term antiviral immune recovery, as well as development of preventive and treatment strategies to improve long‐term outcomes in such patients.
Multiplex technologies for the assessment of minimal residual disease and low‐level mutation detection in leukaemia: mass spectrometry versus next‐generation sequencing
Authors: Shanmuganathan Naranie , Branford Susan 
Published: June 2021

SummaryWith the focus of leukaemia management shifting to the implications of low‐level disease burden, increasing attention is being paid on the development of highly sensitive methodologies required for detection. There are various techniques capable of identification of measurable residual disease (MRD) either evidencing as relevant mutation detection [e.g. nucleophosmin 1 (NPM1) mutation] or trace levels of leukaemic clonal populations. The vast majority of these methods only permit detection of a single clone or mutation. However, mass spectrometry and next‐generation sequencing enable the interrogation of multiple genes simultaneously, facilitating a more complete genomic profile. In the present review, we explore the methodologies of both techniques in conjunction with the important advantages and limitations associated with each assay. We also highlight the evidence and the various instances where either technique has been used and propose future strategies for MRD detection.
Ten‐year review of neuroimaging in acute paediatric strabismus
Authors: Chong Cheefoong , Allen Natalie , Jarvis Rebecca , Dai Shuan 
Published: June 2021

AbstractBackgroundAcute childhood strabismus is often a clinical conundrum faced by ophthalmologists. Currently, there are no clear clinical guidelines on how to investigate a child presenting with acute strabismus. Furthermore, there is no consensus as to whether to initially perform neuroimaging of a child to rule out the small but serious risk of intracranial pathology, or to pursue a careful observational approach. This paper aims to outline a standardised approach to investigating acute strabismus in paediatric patients.MethodsA retrospective chart review of all paediatric patients that presented over a 10‐year period to the ophthalmology departments at two tertiary level hospitals in New Zealand was conducted. Patients under 18 years of age with an acute presentation of strabismus, who underwent neuroimaging, were included.ResultsA total of 500 patient records were reviewed. Seventy patients met the study inclusion criteria. Of these patients, 17 (24.3%) had non‐isolated strabismus while 53 patients (75.7%) had isolated strabismus. Twelve patients (70.6%) who presented with a non‐isolated strabismus had abnormal neuroimaging. Of those who presented with an isolated strabismus, 4 (7.5%) had abnormal neuroimaging.ConclusionsAcute onset non‐isolated strabismus is a significant predictor of underlying neurological abnormality in children and requires urgent neuroimaging. However, a cautious approach in which there is close observation, along with general paediatric and/or paediatric neurology input, may be appropriate for children presenting acutely with an isolated strabismus.
Toward pharmacogenetic SLCO1B1‐guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model
Authors: Taylor Zachary L. , Thompson Lauren E. , Bear Heather , Mizuno Tomoyuki , Vinks Alexander A. , Ramsey Laura B. 
Published: June 2021

AbstractLow‐dose methotrexate (MTX) is a first‐line therapy for the treatment of arthritis. However, there is considerable interindividual variability in MTX exposure following standard dosing. Polymorphisms in SLCO1B1 significantly effect MTX clearance, altering therapeutic response. One decreased function variant, rs4149056 (c.521T>C, Val174Ala), slows MTX clearance and in vitro uptake of MTX. This phenotype was recapitulated in a mouse model using a knockout (KO) of the murine orthologue, Slco1b2. Our objective was to investigate the impact of this phenotype on the pharmacokinetics and therapeutic outcomes of low‐dose MTX in a murine model of collagen‐induced arthritis (CIA). We evaluated response to MTX in mice with CIA using wildtype (WT), heterozygous, and KO Slco1b2 mice on a DBA1/J background. Arthritis was macroscopically evaluated daily to quantify disease progression. Mice received 2 mg/kg or a pharmacogenetically guided MTX dose subcutaneously 3 times a week for 2 weeks. MTX concentrations were collected at the end of the study and exposure (day*µM) was estimated using a two‐compartment model. Mice displayed a seven‐fold range in MTX exposure and revealed a significant exposure‐response relationship (p = 0.0027). KO mice receiving the 2 mg/kg dosing regimen had 2.3‐fold greater exposure to MTX (p < 0.0001) and a 66% reduction in overall disease progression (p = 0.011) compared to WT mice. However, exposure and response were equivalent when pharmacogenetically guided dosing was used. These studies demonstrate that an exposure‐response relationship exists for MTX and that Slco1b2 genotype affects MTX exposure and therapeutic response. Such evidence supports the use of SLCO1B1‐pharmacogenetic dosing of low‐dose MTX for patients with arthritis.
Assessment of the impact of Japanese‐specific long‐term safety data on new drug approval
Authors: Uzu Shinobu , Sekine Shohko , Asano Junichi , Ikuma Mutsuhiro 
Published: June 2021

AbstractUnder the International Council for Harmonization (ICH)‐E1 guideline for drugs intended for chronic or repeated intermittent use in non‐life‐threatening diseases, data from 100 patients exposed for a minimum of 1 year are required to be included in the safety data base of a new drug application. In response to the recent globalization of drug development, the Ministry of Health, Labour, and Welfare of Japan requires that the data according to the ICH‐E1 guideline should be collected from 100 Japanese patients by the administrative notice of Basic Principles on Global Clinical Trials (reference cases) by considering ethnic differences in safety between Japanese and foreigners. In this study, we assessed Pharmaceuticals and Medical Devices Agency (PMDA) review reports of new drugs from 2016 to 2020 that include safety data for 100 Japanese patients exposed to these drugs for a minimum of 1 year to see if the study data led to the detection of Japanese‐specific safety issues. The result showed that the safety data from these patients provided only marginal value to identify Japanese‐specific safety issues, and no drugs were subjected to regulatory measures. Based on these studies and the fact that Japanese‐specific safety differences detected for a few drugs did not lead to adaptations of drug regulatory measures, we would like to propose not to make it a rule to collect safety data from 100 Japanese patients exposed at least 1 year, while keeping the ICH‐E1 guideline.
The makeshift curtain: A generous Christianity: Ecclesiologies beyond the religious‐secular binary1
Authors: Wyller Trygve 
Published: June 2021

AbstractThe article discusses how one might reflect further on ecclesiological impacts from Scandinavian creation theology (SCT). The idea is that the SCT from Gustaf Wingren and Knud Ejler Løgstrup opens for an ecclesiology beyond the secular‐religious binary. A generous Christianity appears when practices of non‐faith (secularity) take place within ecclesia. The article discusses a concrete case from the Swedish congregation Bergsjøen where a makeshift curtain for visiting Muslims is constructed in the church basement. The makeshift curtain could be interpreted as a representation of creation and in this way being an important part of the ministry as a whole. The article discusses with recent Nordic and international ecclesiological and political theology. The conclusion is that, different from Catherine Keller's proposal of a “weak” political theology, SCT opens for an embodied, generous, Christianity.
What is the value of simulated patient assessment in structured clinical examinations of undergraduate students, and how should it be used?
Authors: Ali K. , Hanks S. , Cockerill J. 
Published: June 2021

AbstractIntroductionThe aim of this study was to explore correlations between clinical assessor and simulated patient (SP) scores drawn from summative Integrated Structured Clinical Examination (ISCE) and inform the best use of SP scores in future assessments.Materials and MethodsThis retrospective study explores summative clinical assessor and formative SP numeric scores drawn from summative ISCE assessments spanning three academic years (2017–18 to 2019–20). Analyses were carried out using R 3.5.1 (R Core Team, 2018), with the stats package.ResultsThe sample consisted of 169 final‐year BDS students across the three cohorts and included 95 females (56.2%) and 74 males (43.8%). Data from eight substations where SPs were included, were explored. Kendall's Tau, a non‐parametric correlation, was used to investigate the relationships between the assessor and SP scores. Clinical assessor scores were out of a total of 20 points across various assessed domains within each substation. The formative SP assessment was out of 10 points with the same five affective domains related to communication included in each substation. Overall, the assessor and patient substation scores were not correlated (τ = 0.04, p = .272) indicating that communication skills alone, as assessed by patients, do not correlate with more holistic performance across other domains. There was significant positive correlation for two of the eight substations with the other substations showing very little correlation.ConclusionThis study shows that assessment of student performance by SPs does not show a correlation with examiner scores and may provide additional information relating to affective skills of students. Notwithstanding the limitations of this study, the findings underscore the need to investigate further the value of involvement of SPs in clinical assessments to explore if scores by SPs can be used to enhance the validity of assessments if used summatively.
Global distribution and evolutionary transitions of angiosperm sexual systems
Authors: Wang Yunyun , Luo Ao , Lyu Tong , Dimitrov Dimitar , Xu Xiaoting , Freckleton Robert P. , Li Yaoqi , Su Xiangyan , Li Yichao , Liu Yunpeng , Sandanov Denis , Li Qingjun , Hao Zhanqing , Liu Shuguang , Wang Zhiheng 
Published: June 2021

AbstractAngiosperm sexual systems are fundamental to the evolution and distribution of plant diversity, yet spatiotemporal patterns in angiosperm sexual systems and their drivers remain poorly known. Using data on sexual systems and distributions of 68453 angiosperm species, we present the first global maps of sexual system frequencies and evaluate sexual system evolution during the Cenozoic. Frequencies of dioecy and monoecy increase with latitude, while hermaphrodites are more frequent in warm and arid regions. Transitions to dioecy from other states were higher than to hermaphroditism, but transitions away from dioecy increased since the Cenozoic, suggesting that dioecy is not an evolutionary end point. Transitions between hermaphroditism and dioecy increased, while transitions to monoecy decreased with paleo‐temperature when paleo‐temperature >0℃. Our study demonstrates the biogeography of angiosperm sexual systems from a macroecological perspective, and enhances our understanding of plant diversity patterns and their response to climate change.