bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instagram Content Addressing Pruritic Urticarial Papules and Plaques of Pregnancy: Observational Study
Authors: Payton Ashley , Woo Benjamin K P 
Published: January 2021

Background
Pruritic urticarial papules and plaques of pregnancy (PUPPP) is the most commonly diagnosed pregnancy-specific dermatosis. It presents with intense pruritus and can be difficult to manage, which encourages mothers to look to social media for camaraderie and advice.

Objective
This study aimed to characterize the sources and thematic content of Instagram posts in order to define influential groups of users. Our goal was to determine the status of online discourse surrounding PUPPP and elucidate any potential space for health care provider intervention via creation of Instagram accounts dedicated to information dissemination for patient populations.

Methods
Three hashtag categories were selected (#PUPPP, #PUPPPs, and #PUPPPrash), and the top public posts from each were analyzed and organized by source and by thematic content. The numbers of likes and comments were also recorded.

Results
Among the top 150 posts in each hashtag category, only 428 posts in total were eligible for this analysis. Majority (316/428, 73.8%) of posts were created by mothers who experienced PUPPP. These posts were testimonial accounts in nature. A small fraction of posts (14/428, 3.3%) were generated by physician accounts. Posts from blogs with extensive followings garnered the most attention in the form of likes and comments.

Conclusions
Mothers experiencing PUPPP comprised the majority of accounts posting under the hashtags selected. The most common themes included pictures of the rash and personal testimonies. Posts under blog posts received the most likes and comments on average. There is space for physician and health care specialists to improve their social media presence when it comes to discourse surrounding PUPPP. Patients are seeking out communities on social media, like Instagram, in order to have questions answered and obtain advice on management. Accounts with large followings tend to have more likes and more comments, which encourages information dissemination and awareness. Thus, we suggest that physicians create content and potentially partner with blog-type accounts to improve outreach.
The effect of Zirconium Dioxide nanoparticles concentrations as filler on heat cured acrylic resin denture base toward viability of fibroblast cells (in vitro study)
Authors: S Rudy , Ismiyati Titik , Wahyuningtyas Endang 
Published: January 2021

Heat cured acrylic resin is the most commonly used denture base materials. Zirconium dioxide (ZrO2) nanoparticles can be applied as additional filler to increase mechanical strength and to reduce the amount of residual monomer. The aim of this research is to analyze the effect of ZrO2 nanoparticles concentrations as filler on heat cured acrylic resin denture base toward viability of fibroblast cells. Twenty four disc-shaped heat cured acrylic resin plate (diameter 5 mm; width 2 mm), were divided into 4 groups (n=6), they were consisted of group I control (acrylic resin), group II acrylic resin with 2.5% ZrO2, group III acrylic resin with 5% ZrO2, and group IV acrylic resin with 7.5% ZrO2. Cell viability was obtained using MTT assay and ELISA plate reader. The result is examined with one way ANOVA followed by LSD post hoc assessment. The result showed highest cell viability percentage on experimental group of 2.5% ZrO2 with value as high as 97.49%. One way ANOVA test and LSD post hoc test showed a significant difference between groups (p<0.05). The conclusion of this research is ZrO2 nanoparticles concentration utilized as filler on heat cured acrylic resin denture base is effect to viability of fibroblast cells, and ZrO2 nanoparticles 2.5% shows the highest viability of fibroblast cell compared to 5% and 7.5% ZrO2 nanoparticles concentrations
ROLE OF THE PHARMACIST IN MANAGING HIGH BLOOD PRESSURE OF HYPERTENSIVE PATIENTS IN PRIMARY CARE UNITS
Authors: DE SOUZA JÚLIO EDUARDO PEREIRA , SILVA EMERSON , NOVO NEIL FERREIRA , SHIO MARINA TIEMI 
Published: January 2021

Objective: The aim of this study was to evaluate the influence of pharmaceutical care on the control of high blood pressure (BP) in hypertensive patients.
Methods: The study included thirty hypertensive patients from primary or secondary healthcare located in the south of São Paulo, Brazil.
Results: The majority of patients was aged over 60 years (68.75%), non-smokers (90%), non-alcoholics (93.33%), did not practice physical activities (93.33%), and presented comorbidities and polypharmacy. The most common drug-related problems were drug-drug interactions, missed doses, incorrect frequency or time of administration, incorrect patient administration technique, and self-medication. The interventions used during the pharmaceutical consultations (PC) were based on the organization of medicines with tools such as a pillbox organizer (84.38%). A significant improvement in BP control (p<0.05) was observed when comparing BP measurements before and after the PC; however, the number of PCs did not influence the BP reduction.
Conclusion: Patient guidance and a simple intervention favor better patient understanding of medication administration schedules.
COMPARISON OF EFFICACY AND SAFETY OF ORMELOXIFENE AND CYCLICAL PROGESTERONE (NORETHISTERONE) IN OVULATORY ABNORMAL UTERINE BLEEDING
Authors: VARDAINI DIVYA , MISHRA RAKESH , RANJAN RASHMI , BORADE SWAPNALI R 
Published: January 2021

Objective-To determine the efficacy and safety of ormeloxifene versus progesterone in controlling Ovulatory Abnormal Uterine Bleeding(AUB-O)
Methods-A Prospective Randomized comparative study of total 100 females of reproductive age group 25 to 45 years with AUB-O.Patients were randomly divided in two groups of 50 each.
Results-The study showed ormeloxifene was found to be more effective and safe than Norethisterone in AUB-O. Ormeloxifine as compared to norethisterone is more effective in improving Hb and reducing endometrial thickness. Hence, ORM is more superior than Norethisterone
Conclusion-In this study ormeloxifene was found to be more effective in reducing blood loss,that leads to improvement in mean haemoglobin and also it had more ability to reduce endometrial thickness.As both ormeloxifene and norethisterone are very effectivebut ormeloxifene is safe , cost effective ,nonsteroidal, non hormonal drug with convenient dosage and better compliance for medical management of AUB-O.Hence, ormeloxifene canbe considered as first drugs in the management of AUB-O.
ROSUVASTATIN CALCIUM PRONIOSOME POWDER: A NOVEL APPROACH TO IMPROVE INTESTINAL ABSORPTION AND BIOAVAILABILITY
Authors: GANDRA SMITHA 
Published: January 2021

Objective: The main objective of the present study was to develop proniosomal formulations to enhance the oral bioavailability of rosuvastatin calcium by improving solubility, dissolution, and/or intestinal permeability.
Methods: Proniosomal powder formulations were prepared with rosuvastatin calcium drug varying the Span 40 and cholesterol ratio in the range of 0.8:0.2–0.2:0.8 using maltodextrin as carrier by slurry method. The prepared proniosomal powder was filled into capsules. The bioavailability enhancement of proniosomes loaded with drug was studied focusing on non-ionic surfactants composition and drug:Span 40 ratio. Prepared proniosomes were characterized for their particle size distribution, zeta potential, entrapment efficiency, in vitro dissolution study, and thermal characteristics to understand the phase transition behavior. Further, the formulated proniosomes were subjected to stability behavior, ex vivo permeation studies using rat intestine followed by in vivo studies.
Results: Physicochemical studies help in optimization of formulations. Enhancement in dissolution is due to incorporation of rosuvastatin calcium into the non-ionic surfactant and change in the physical state from crystalline to amorphous, thus improving oral bioavailability. Ex vivo studies show significant permeation enhancement across gastrointestinal membrane compared to control.
Conclusion: Proniosomes provide a powerful and functional way of distribution of inadequately soluble rosuvastatin calcium drug which is proved from in vivo studies based on the enhanced oral delivery.
Pre-engorda de semillas de cultivo de la almeja taquilla, <i>Mulinia edulis</i>, en un sistema suspendido en el mar
Authors: Oliva Doris , Célis Angela del Pilar , Abarca Alejandro , Pizarro Marlene , Durán L. René 
Published: January 2021

Semillas (spats) de Mulinia edulis, producidas en hatchery, se engordaron durante 40 días, en un sistema de cultivo suspendido (long-line) en el mar en Bahía Yal (Chiloé, Chile), con el objetivo de probar la factibilidad de pre-engorda. Se utilizaron dos tamaños de siembra 2,9 y 6,2 mm y dos densidades [1 (D1) y 2 (D2) semillas cm-2] en tratamientos con (TA) y sin arena (TSA) con semillas pequeñas. Se determinó el crecimiento y la supervivencia de semillas pequeñas en long-line instalados en la periferia y en el centro de la concesión de acuicultura. En el experimento de tamaño de siembra las semillas pequeñas crecieron en promedio 5,0 mm y las grandes 4,9 mm en TA y en el TSA 0,9 mm y 0,7 mm, respectivamente. La supervivencia de las semillas en TA (pequeñas= 51,3%; grandes= 62,3%) fue mayor que en TSA (pequeñas= 18,9%; grandes= 40,0%). En el experimento de densidad, las mayores longitudes se presentaron en TA, con un crecimiento promedio 5,0 mm en D1 y 4,5 mm en D2. La mayor supervivencia se obtuvo en TA (D1= 51,3%; D2= 49,4%) y la menor en TSA (D1= 18,9%; D2= 7,1%. El crecimiento de las semillas pequeñas fue mayor en los long-line ubicados en la periferia, no observándose diferencias en la supervivencia. Los resultados muestran que es factible realizar una pre-engorda a un tamaño de siembra de 2,9 mm con una densidad inicial de 2 semillas cm-2 en sistemas suspendidos con arena.
Potential of Microbes Containing Formulations to Alter Growth and Phytochemicals of Medicinal Aromatic Plant- Foeniculum Vulgare
Authors: Kamal Jeet  , Ashish Baldi  
Published: January 2021

Sustainable plant production with the integration of eco-friendly agricultural practices, low chemical inputs, minimal deleterious effects on human health and low cost methods, is the need of the moment. In this direction, scientific/industrial community, continuously exploring novel and reliable methods. Plant growth promoting microbes are proving more promising to achieve eco-friendly and sustainable agricultural outcomes. In the present study, individuals of Foeniculum vulgare, a valuable aromatic plant species with potential medicinal value, were inoculated with different plant growth promoting microorganisms: (1) Arbuscular mycorrhizal like fungi (Sebacina vermifera) (2) Phosphate solubilizing bacteria (Pseudomonas fluorescens) (3) Azotobacter (Azotobacter chroococcum). Response of individual microorganism species was evaluated with reference to the emergence, plant growth and yield of essential oil along with qualitative effects on essential oil. Comparatively, significant response of Sebacina vermifera, in the stimulation of emergence of seeds, growth of plant and yield enhancement of essential oil was observed. An enhanced synthesis of anethole (major chemical constituent) was also recorded. Moreover, the enhancement in growth of plants was dependent on the extent of colonization percentage. A periodic study of growth parameters indicates plant’s health and vitality influenced by Sebacina vermifera. The enhanced essential oil of seeds along with enhanced synthesis of anethole was in agreement with the assumption that Sebacina vermifera trigger defensive responses and hence improve phytochemical production. A mechanistic insight is also illustrated. In conclusion Sebacina vermifera possesses immense potentials in the pursuit of agro-ecological attributes of medicinal plant cultivation and crop production. It exerts excellent growth effects and enhances phytochemical production in medicinal plants.
DERAJAT KETERPAPARAN KONTEN PORNOGRAFI PADA SISWA SMP DAN SMA DI DKI JAKARTA DAN BANTEN INDONESIA
Authors: Maisya Iram Barida , Masitoh Siti 
Published: January 2021

Abstract
Background: Indonesia ranks third as the highest number of phornographic users. Pornography has many negative effects for adolescents such as the number of adolescents who engage in deviant behavior, the increasing number of adolescents who are sexually active, will also increase cases of unwanted pregnancy, abortion and brain damage.
Objective: To determine the degree of pornographic exposure among junior and high school students in Jakarta and Banten
Method: This research was conducted in DKI Jakarta and Banten on 1340 junior and senior high school students with cross sectional design. This study used an early detection instrument of pornographic content developed by the Education and Culture Policy Research Center Team, Ministry of Education and Culture in 2017 that has been validated.
Result: The majority of adolescents (94.5%) have been exposed to pornographic content in grade 1 category, 3,7% in grade 2, and 0,1% in grade 3. Adolescents who were exposed in grade 1 were more likely to be girls (96.7%), but more boys were exposed to grade 2 (6.7%) and grade 3 (0.2%). More students from junior high school were exposed in grade 1 (95.1%), but more students from senior high school were exposed in grade 2 (4%), and grade 3 (0.1%).
Conclusion: Most students have been exposed to pornographic content and intervention was needed according to the degree of exposure.
Key words: early detection, pornography adiction, pornography
Abstrak
Latar belakang: Indonesia menduduki peringkat ketiga sebagai negara dengan jumlah pengakses pornografi terbanyak. Pornografi memberikan banyak dampak negatif bagi remaja seperti banyaknya remaja yang melakukan perilaku menyimpang, meningkatnya jumlah remaja yang berperilaku seksual aktif, juga akan meningkatkan kasus kehamilan tidak diinginkan (KTD), tindakan aborsi, dan kerusakan otak.
Tujuan: Mengetahui gambaran derajat keterpaparan konten pornografi pada siswa SMP/MTs dan SMA/MA di DKI Jakarta dan Banten.
Metode: Penelitian ini dilakukan di DKI Jakarta dan Banten pada 1340 siswa SMP/MTs dan SMA/MA dengan desain cross-sectional. Penelitian ini menggunakan instrumen deteksi dini konten pornografi yang dikembangkan oleh Tim Pusat Penelitian Kebijakan Pendidikan dan Kebudayaan, Kementerian Pendidikan dan Kebudayaan pada tahun 2017 yang sudah diuji validitas dan reliabilitasnya.
Hasil: Sebagian besar siswa sudah terpapar pornografi derajat 1 (94,5%), ada 3,7 persen siswa yang terpapar derajat 2, dan 0,1 persen yang terpapar derajat 3. Remaja yang terpapar derajat 1 lebih banyak pada perempuan (96,7%), tetapi laki-laki justru lebih banyak yang terpapar pornografi derajat 2 (6,7%) dan derajat 3 (0,2%). Siswa SMP/MTs lebih banyak yang terpapar pornografi derajat 1 (96,1%), dan siswa SMA/MA lebih banyak yang terpapar derajat 2 (4%), dan derajat 3 (0,1%).
Kesimpulan: Sebagian besar siswa sudah terpapar materi pornografi dan diperlukan intervensi sesuai dengan derajat keterpaparannya.

Kata kunci: deteksi dini, adiksi pornografi, pornografi
Jogos Educacionais Digitais no Ensino Infantil: Uma Revisão Sistemática da Literatura
Authors: Cruz Araújo Lucineide , Andryê Galvão Madeira Charles 
Published: January 2021

As crianças estão imersas na cultura digital. Mesmo antes de frequentarem a escola, fazem uso de aparatos tecnológicos com interfaces de interação sensíveis ao toque, como é o caso dos jogos digitais, muitas vezes sem mediação. Este artigo tem por objetivo investigar trabalhos que analisam como os jogos educacionais digitais estão contribuindo no processo de ensino e aprendizagem das crianças da Educação Infantil. Para isso propõe uma revisão sistemática da literatura. Como resultado, verificou-se que os trabalhos analisados destacam o uso dos jogos digitais como uma importante ferramenta para a prática pedagógica e para a aprendizagem da criança, embora ainda existam lacunas de investigações no que se refere à relação dos jogos digitais com os campos de experiência citados pela BNCC, de forma que possibilite o desenvolvimento de habilidades.
Recurso Educacional Digital (RED) para os anos iniciais do Ensino Fundamental aspectos pedagógicos e a Base Nacional Comum Curricular
Authors: Araújo Hitzschky Rayssa , Aires de Castro Filho José , Santiago Freire Raquel 
Published: January 2021

Este estudo teve como objetivo compreender os aspectos pedagógicos envolvidos no desenvolvimento de um Recurso Educacional Digital (RED) de Língua Portuguesa, fundamentado nas habilidades da Base Nacional Comum Curricular (BNCC). De natureza qualitativa, do tipo estudo de caso, a pesquisa parte do pressuposto de que é preciso aprofundar o desenvolvimento de RED a partir de aspectos de natureza pedagógica e não somente técnica. A pesquisa evidenciou elementos importantes do desenvolvimento pedagógico, como: Alinhamento teórico, Intencionalidade pedagógica e Consistência técnico-pedagógica. Esses aspectos devem ser considerados no desenvolvimento de RED, como parte primordial do desenvolvimento de recursos.
EL APRENDIZAJE COOPERATIVO. UNA METODOLOGÍA PARA EL MEJORAMIENTO DEL APRENDIZAJE EN EL AULA. COOPERATIVE LEARNING.A METHODOLOGY FOR IMPROVING LEARNING IN THE CLASSROOM.
Authors: Suárez Valdés-Ayala Zuleyka 
Published: January 2021

En este artículo se expone el proceso seguido para llevar a cabo una investigación sobre aprendizaje cooperativo en matemática en un aula de sexto grado, exponiendo los resultados de algunos instrumentos utilizados con los estudiantes para poder evidenciar las ventajas de utilizar esta metodología en el salón de clase.Palabras clave: Aprendizaje cooperativo, aula, enseñanza, matemática, investigaciónAbstractThis article will outline the process used to conduct a research on cooperative learning in mathematics in a sixth grade classroom, giving the results of some instruments used with students to demonstrate the advantages of using this methodology in the classroom.Keywords: Cooperative learning, classroom, teaching, mathematics, research
LA TRANSVERSALIDAD: UNA OPORTUNIDAD PARA FORTALECER EL CURRÍCULO EN LA EDUCACIÓN SUPERIOR DESDE LA GESTIÓN INSTITUCIONAL. TRANSVERSALITY: A HUGE OPPORTUNITY TO ENHANCE SUPERIOR EDUCATION’S CURRICULUM FROM INSTITUTIONAL MANAGEMENT
Authors: Tencio-Blanco Carolina Belén 
Published: January 2021

Este artículo presenta el tema de la transversalidad, exponiendo la importancia que conlleva su incorporación en la formación académica que ofrecen las universidades, siendo una temática que aún presenta interrogantes más en su parte práctica desde el qué y el cómo. Desde la experiencia académica del diseño curricular y la docencia, se visualiza en el accionar de las instituciones educativas, la dificultad del manejo de esta herramienta pedagógica en la gestión que realizan diversas instituciones, para poder integrarla como proyecto y cultura institucional. La exposición de la temática, pretende, enmarcar la necesidad de ser un tema prioritario en las mesas de discusión académica, ya que solo así se podrá llegar a propuestas del adecuado manejo e incorporación de los ejes transversales desde lo que compete al accionar institucional.Palabras clave: transversalidad, ejes transversales, educación, currículo, gestión institucional.AbstractThis document refers to transversality, showing its relevance when introduced in formal education in colleges. This subject still has plenty of unanswered questions on its how to, side of implementation. From the Academic Experience’s point of view while teaching and throughout curricular design, it is envisioned to work properly on all educational institutions; though this pedagogical tool is hard to implement in the daily functions of the learning centers as part of its curriculum and institutional culture. This dissertation tries to expose the relevance and the need of “transversality” of becoming a priority subject in all educational discussion boards; this is considered as the only possible route to generate the proper aproach and incorporation of the transversal axes from the institutional actions point of view.Keywords: transversality, superior education, transversal axes, curriculum, institutional management
PEDAGOGÍA Y ADMINISTRACIÓN ESCOLAR: RETOS Y DESAFÍOS. PEDAGOGY AND MANAGING SCHOOL: CHALLENGES
Authors: Vargas-Jiménez Ileana 
Published: January 2021

El artículo trata de hacer un acercamiento de la pedagogía con la idea principal de comprender cuál es la vinculación con la administración educativa. Para ello se esbozan algunos retos y desafíos que debe encarar la administración educativa escolar como son los valores, la educación para la paz y la inteligencia emocional, no sin antes mencionar algunos elementos en torno a la pedagogía científica y positivista, la teoría de sistemas. En las reflexiones finales se hace mención de cómo es necesario replantear la administración educativa sin perder de vista que ésta debe ser asumida de manera participativa por todos los miembros del centro escolar.Palabras clave: pedagogía, administración, escuela, valores, inteligencia emocional.Abstract. The article tried to explain the pedagogical and how the education administration is about. Also mention some challenger as values, education to the peace, emotional intelligence could be involved in the education administration. In the final reflection is necessary to understand that administration must be implicit for all members of the institution.Keywords: pedagogical, administration, school, values, emotional intelligence.