bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Dimensional Nonlinear Vibration Model and Fatigue Failure Mechanism of Deep-Water Test Pipe
Authors: Guo Xiaoqiang , Nie Yuxin , Liu Jun , He Yufa , Mao Liangjie , Wang Guorong , Dai Liming 
Published: September 2021

Abstract
In deep-water test conditions, the riser-test pipe system (RTS) is subject to the vortex induced effect on riser, flow induced effect on test pipe and longitudinal/transverse coupling effect, which is prone to buckling deformation, fatigue fracture and friction perforation. To resolve this, the three-dimensional (3D) nonlinear vibration model of deep-water RTS is established using the micro-finite method, energy method and Hamilton variational principle. Based on the elastic-plastic contact collision theory, the nonlinear contact load calculation method between riser and test pipe is proposed. Compared with experimental measurement results, calculation results of the proposed vibration model in this study and the single tubing vibration model in our recent work, the correctness and effectiveness of the proposed vibration model of the deep-water RTS are verified. Meanwhile, the cumulative damage theory is used to establish the fatigue life prediction method of test pipe. Based on that, the influences of outflow velocity, internal flow velocity, significant wave height, as well as top tension coefficient on the fatigue life of test pipe are systematically analyzed. The results demonstrate that, first, with the increase of outflow velocity, the maximum alternating stress, the annual fatigue damage rate increased and the service life decreased significantly. The locations where fatigue failure of the test tube is easy to occur are mainly distributed at the upper “one third” and the bottom of test pipe. Second, with the increase of internal flow velocity, the “one third effect” of the test pipe will decrease, and is shown “the bottom damage effect”, which needs the attention of field operators. Third, during field operation, it is necessary to properly configure the top tension coefficient so that there can be a certain relaxation between the riser and the test pipe, so as to cause transverse vibration and consume some axial energy and load. The study led to the formulation of a theoretical method for safety evaluation and a practical approach for effectively improving the fatigue life of deep-water test pipe.
Tree – Open Grassland Structure Drives Carbon And Nitrogen Cycling In Mediterranean Wood Pastures of The Iberian Peninsula
Authors: Ibañez Mercedes , Aljazairi Salvador , Leiva María José , Werner Roland A. , Ghashghaie Jaleh , Sebastià Maria Teresa 
Published: September 2021

Abstract
Purpose: Mediterranean wood pastures are the largest agroforestry system in Europe. Traditional silvo-pastoral uses shaped these systems into a mosaic of trees and open grassland. However, little is known about how this structure may influence ecosystem carbon (C) and nitrogen (N) dynamics, considering different canopy types and interactions with the herbaceous layer.Aims: To unravel the canopy effect on C and N dynamics (1) under representative canopy types, including traditional Quercus stands and Pinus pinea L. plantations; and (2) in interaction with the herbaceous plant functional types (PFT).Methods: We analysed C and N content and the isotopic natural abundance on soil and plant materials at the open grassland and under the different tree canopies.Results: Under the canopy, soil C and N content, and N availability for the herbaceous layer increased. The canopy effect performed differences between Quercus and P. pinea plots, as detected on the belowground biomass C content. Also, the canopy effect was more pronounced with increasing environmental constraints, highlighting the relevance of trees in more restrictive environments. PFT ecophysiological characteristics interacted with tree canopies, as reflected the enhanced efficiency taking-up N, and/or exploiting symbiotic N of grasses, which was probably one of the causes of their dominancy under the canopy, at higher N availability.Conclusion: Changes in the tree coverage and tree species will significantly change ecosystem C and N storage and cycling. Therefore, it is highly advisable to preserve a balance between trees and open grassland, and traditional Quercus stands, to keep ecosystem services provisioning.
Personality Traits and Anxiety in Patients With Temporomandibular Disorders
Authors: Hekmati Atefeh , Mortazavi Nazanin , Ozouni-Davaji Rahman Berdi , Vakili Mohammad Ali 
Published: September 2021

Abstract
BackgroundTemporomandibular disorders have long been suggested to result from psychological factors. Recent studies, however, tend to consider TMD a chronic psychosomatic illness. The present study was designed to explore the association between TMD and personality profile. The Minnesota Multiphasic Personality Inventory-2-Reconstructed form was used to evaluate the association for the first time.MethodsA total of 258 subjects were participated in this case-control study. TMD cases as detected by Helkimo index were questioned regarding their personality characteristics and anxiety levels using MMPI-2-RF and Spielberger state and trait anxiety inventory.ResultsPatients with TMD scored higher on all personality characteristics except for Aberrant Experiences. The psychological profile of TMD showed no significant difference between theoretical and experimental ideas of persecution means. Patients with TMD reported significantly higher mean levels of state and trait anxiety than controls. The most frequently found anxiety levels in TMD cases have been mild state and trait anxiety (77.5% versus 74.4%).ConclusionPersonality characteristic scores were considerably higher in TMD patients. TMD cases detected by Helkimo index manifest both trait and state anxiety as common findings.
MAPPINGS v1.0, a tool for network analysis of large phospho-signalling datasets: application to host erythrocyte response to Plasmodium infection
Authors: Adderley Jack , O'Donoghue Finn , Davis Stephen , Doerig Christian 
Published: September 2021

Abstract

Phosphorylation-based signalling implicates a complex and intertwined series of pathways and is critical to all domains of life. The interconnectivity between pathways results in the emergence of complex networks whose elucidation present a serious challenge. Large datasets of phosphorylation interactions through the activity of kinases on their numerous substrates are constantly being generated, however deciphering the complex network structure hidden in these datasets remains challenging. Many phosphorylation interactions occurring in human cells have been identified and constitute the basis for the known phosphorylation interaction network. We overlayed onto this network phosphorylation datasets obtained from an antibody microarray approach aimed at determining changes in phospho-signalling of host erythrocytes to infection with the malaria parasite Plasmodium falciparum. To analyse the datasets now mapped into the interaction network, we designed a pathway analysis tool denoted MAPPINGS that uses random walks to identify chains of phosphorylation events occurring much more or much less frequently than expected. MAPPINGS highlights pathways of phosphorylation that work synergistically, providing a rapid interpretation of the most critical pathways in each dataset. MAPPINGS confirmed several signalling interactions previously shown to be modulated by infection, and revealed additional interactions which could form the basis of numerous future studies. The MAPPINGS analysis strategy described here is widely applicable to comparative phosphorylation datasets in any context (e.g. response of cells to infection, treatment, or comparison between differentiation stages of any cell populations) and provides a rapid and reliable analysis to guide validation studies.
Urinary Extracellular Vesicles contain simplified transcriptomes enriched in circular &amp; long noncoding RNAs with functional significance in prostate cancer
Authors: Almeida anna , Gabriel Marc , Firlej Virginie , Martin-Jaular Lorena , Lejars Matthieu , Cippola Rocco , Vogt Nicolas , Destouches Damien , Vacherot Francis , Taille Alexandre De la , Théry Clotilde , Morillon Antonin 
Published: September 2021

Abstract
Long noncoding (lnc)RNAs modulate gene expression alongside presenting unexpected source of neoantigens. Despite their immense interest, their ability to be transferred and control adjacent cells is unknown. Extracellular Vesicles (EVs) offer a protective environment for nucleic acids, with pro and anti-tumorigenic functions by controlling the immune response. In contrast to extracellular non-vesicular RNA, few studies have addressed the full RNA content within human fluids’ EVs and none have compared them with their tissue of origin. Here, we performed Total RNA-Sequencing on 6 Formaldehyde-Fixed-Parafilm-Embedded (FFPE) prostate cancer (PCa) tumor tissues and their paired urinary (u)EVs to provide the first whole transcriptome comparison from the same patients. UEVs contain simplified transcriptome with intron-free cytoplasmic transcripts and specific lnc/circular (circ)RNAs, strikingly common to all patients. Our full cellular and EVs transcriptome comparison within 3 common PCa cell lines identified a set of overlapping 14 uEV-circRNAs characterized as essential for prostate cell proliferation in vitro and 15 uEV-lncRNAs that we predicted to encode 768 high-affinity neoantigens. Our dual analysis of EVs-lnc/circRNAs both in urines’ and in vitro’s EVs provides a fundamental resource for future uEV-lnc/circRNAs phenotypic characterization involved in PCa.
Experience of Serious Intestinal Hemorrhage and Perforation in Small Bowel Lymphoma: A Case Report
Authors: Kim Seo Ree , Chun Sang Hoon , Jin Jong Youl , Gweon Tae-Geun , Lee Hayemin , Jin Min-Sun , Lee Guk Jin 
Published: September 2021

Abstract
Background: There have been several reports of complications of small bowel lymphoma, such as bleeding, obstruction, and perforation, which require emergency surgery. It is hardly showed complication of bleeding and wound dehiscence for diffuse large B cell lymphoma with distal ileum involvement, which needed urgent surgery and medical management. Chemotherapy is also important when treating small bowel lymphoma, but complications such as bleeding and perforation should always be kept in mind.Case presentation: A 65 year-old man with stage III diffuse large B-cell lymphoma of the activated-B cell (ABC) type with distal ileum involvement experienced both intestinal bleeding and perforation during the course of treatment. As the patient was diagnosed with stage III disease, resection before chemotherapy was not considered due to the resulting delay in chemotherapy, which necessitated sufficient tissue healing. Conclusion: As shown in this case, complications such as bleeding and perforation should always be considered for the treatment of small bowel lymphoma, and surgery is necessary in this situation. After surgery of the small bowel, subsequent chemotherapy could cause the wound dehiscence and perforation; therefore, adequate recovery time should be given before chemotherapy.
Group I lytic polysaccharide monooxygenase (LPMO1) is required for efficient chitinous cuticle turnover during insect molting
Authors: Qu mingbo , Kim Myeongjin , Guo Xiaoxi , Mun Seulgi , Tian Shuang , Noh Mi Young , Kramer Karl J , Muthukrishnan Subbaratnam , Arakane Yasuyuki , Yang Qing 
Published: September 2021

Abstract
Microbial lytic polysaccharide monooxygenases (LPMOs) catalyze the oxidative cleavage of crystalline polysaccharides including chitin and cellulose. The discovery of a large assortment of LPMO-like proteins widely distributed in insect genomes suggests that they could be involved in assisting chitin degradation in the exoskeleton, tracheae and peritrophic matrix during development. However, the physiological functions of insect LPMO-like proteins are still undetermined. To investigate the functions of insect LPMO subgroup I-like proteins, which contain an AA15 LPMO catalytic domain and a conserved C-terminal cysteine-rich motif, two evolutionarily distant species, Tribolium castaneum and Locusta migratoria, were chosen for study. RNAi for the T. castaneum protein, TcLPMO1, caused molting arrest at all developmental stages, whereas RNAi of the L. migratoria protein, LmLPMO1, prevented only adult eclosion. In both species, LPMO1-deficient animals were unable to shed their exuviae and died. TEM analysis revealed failure of turnover of chitinous cuticle, which is critical for completion of molting. Purified recombinant LPMO1-like protein from Ostrinia furnacalis (rOfLPMO1) exhibited oxidative cleavage activity and substrate preference for chitin. These results reveal for the first time the physiological importance of catalytically active LPMO1-like proteins from distant insect species and provide new insight into the enzymatic mechanism of chitin turnover during molting.
Impact of Hypertension on Pathological Features of Papillary Thyroid Cancer: A Large Sample Single-Center Study
Authors: Li Ling-Rui , Song Jun-Long , Yu Xi-Zi , Zhan Ling , Liu Han-Qing , Chen Chuang 
Published: September 2021

Abstract
Background: Hypertension (HTN) is known to increase the risk of thyroid cancer. However, few studies have explored the association between HTN and the prognostic factors of papillary thyroid cancer (PTC). Methods: We retrospectively evaluated PTC patients treated with surgery at our center between January 2017 and September 2020. The association between both HTN and antihypertensive drug use and the clinicopathological features of the PTC patients was analyzed. The odds ratios (OR) were estimated using both univariate and multivariate logistic regression models, which were adjusted for the patients’ age, sex, and thyroid-stimulating hormone level.Results: A total of 2838 patients were enrolled in this study, including 409 patients with HTN. In the multivariate analysis, HTN was associated with larger tumor size [OR = 1.51, 95% confidence interval (CI): 1.10–2.07] and lymph node metastasis (OR = 1.43, 95% CI: 1.02–1.99). There was no statistical difference between females older than 40 years of age and any pathological features, while a positive association between older males and larger tumors (OR=1.87, 95% CI: 1.014-3.45), lymph node metastasis (OR=2.01, 95% CI: 1.08-3.73), and capsule invasion (OR = 1.98, 95% CI: 1.002–3.91). With regard to antihypertensive drug use, the patients taking enzyme inhibitors or angiotensin II-receptor blockers (ACEi/ARB) seemed more likely to develop bilateral PTC comparing ones using calcium channel blockers (CCB) alone, while no statistical difference was found for these taking CCB alone and the combination of CCB and ACEi/ARB. Conclusion: PTC patients with HTN, particularly age >40 males, tend to have invasive features. Antihypertension therapy appears to exert little to no different effect on the pathological characteristics in these patients.
Development and characterization of Silicon Carbide Coating on Graphite Substrate
Authors: Mohammad F.Z , Sharif M. Akhtar , Ahmed Anas , Suhail Muhammad 
Published: September 2021

Abstract
The development of materials with unique and improved properties using low cost processes is essential to increase performance and reduce cost of the solid rocket motors. Specifically advancements are needed for boost phase nozzle. As these motors operate at very high pressure and temperatures, the nozzle must survive high thermal stresses with minimal erosion to maintain performance. Currently three material choices are being exploited; which are refractory metals, graphite and carbon-carbon composites. Of these three materials graphite is the most attractive choice because of its low cost, light weight, and easy forming. However graphite is prone to erosion, both chemical and mechanical, which may affect the ballistic conditions and mechanical properties of the nozzle. To minimize this erosion Pyrolytic Graphite (PG) coating inside the nozzle is used. However PG coating is prone to cracking and spallation along with very cumbersome deposition process. Another possible methodology to avoid this erosion is to convert the inside surface of the rocket nozzle to Silicon Carbide (SiC), which is very erosion resistant and have much better thermal stability compared to graphite and even PG. Due to its functionally gradient nature such a layer will be very adherent and resistant to spallation. Despite its very good adhesion due to its functionally gradient nature, this layer due to its porous nature exhibit poor oxidation performance compared to a dense SiC layer. The current research is focused on synthesizing, characterizing and oxidation testing of a bi-layer; a functionally gradient inner layer and dense outer layer, SiC coating on graphite.
Scalable High-Speed Hybrid Complementary Integrated Circuits based on Solution-Processed Organic and Amorphous Metal Oxide Semiconductors
Authors: Watanabe Shun , Wei Xiaozhu , Kumagai Shohei , Makita Tatsuyuki , Tsuzuku Kotaro , Yamamura Akifumi , Sasaki Mari , Takeya Jun 
Published: September 2021

Abstract
Solution-processed single-crystal organic semiconductors (OSCs) and amorphous metal oxide semiconductors (MOSs) are promising for high-mobility, p- and n-channel thin-film transistors (TFTs), respectively. Organic−inorganic hybrid complementary circuits hence have great potential to satisfy practical requirements; however, some chemical incompatibilities between OSCs and MOSs, such as heat and chemical resistance, conventionally make it difficult to rationally integrate TFTs based on solution-processed OSC and MOS into the same substrates. In this work, we achieved a rational integration method based on the solution-processed semiconductors by carefully managing the device configuration and the deposition and patterning techniques from materials point of view. The balanced high performances as well as the uniform fabrication of the TFTs led to densely integrated five-stage ring oscillators with the stage propagation delay of 1.3 µs, which is the fastest operation among ever reported complementary ring oscillators based on solution-processed semiconductors.
Thermomechanical Analysis of Friction Stir Welding by Using a New Velocity-Based Model for Tool-Workpiece Interaction
Authors: Sun Zhen , Liu Pengfei , Yu Xinghua 
Published: September 2021

Abstract
The friction stir spot welding test was designed to measure the coefficient of friction on the tool-workpiece contact interface under different tool rotation speeds. The boundary velocity of the workpiece material was calculated based on the stress state of the material on the contact interface. An integrated computational fluid dynamics (CFD) model of friction stir welding (FSW) was established based on the matrix's coefficient of friction and boundary velocity to simulate heat and mass transfer. A more realistic boundary velocity distribution was acquired. A method was introduced to predict strain along a streamline by integrating the strain rate along with the streamline's reverse. The nephogram of strain on the transverse cross-section of weldment displays that strain at the advancing side (AS) is more significant than that at the retreating side (RS), and strain increases as the distance from the shoulder surface decrease. Strain in some regions can be tremendous if the material flows through the rotation flow zone. Wall heat flux on tool-workpiece contact interface at RS is more significant than that at AS. The maximum temperature was observed at the front part of RS. The model is validated since the predicted temperature profile agrees well with corresponding experimental results.
The Role of Admission Scores in Predicting Academic Performance in Medical Students
Authors: Idris Fazean , Chaw Li Ling , Knights Joe , Lim Ya Chee 
Published: September 2021

Abstract
BackgroundAdmission scores have been used to select highly capable students for an undergraduate medical programme. This study examines the relationship between three admission criteria: (i) multiple-mini-interview (MMI); (ii) pre-university final results (PUFR); (iii) entrance scores (combination of 50% MMI and 50% PUFR), with students’ academic performance in the medical programme at Universiti Brunei Darussalam (UBD).MethodsWe performed linear regression analysis on 125 students who completed the programme from 2013 to 2018 and compared their MMI, PUFR and entrance scores with their academic performance throughout their three years of undergraduate study. Academic performance outcomes were assessed from students’ Grade Point Average (GPA), cumulative Grade Point Average (cGPA) and marks in the modules ‘Health Sciences’ (HS), ‘Patient Care’ (PC), ‘Our Community and Personal Professional Development’ (OCPPD) and Special Study Modules, for overall (six-semesters average) and individual semesters.ResultsSimple linear regression results revealed that one unit increase in MMI score was associated with a significant increase in overall PC marks by 0.09. A 20-unit increase in PUFR was associated with a significant increase in students’ cGPA by 0.05; overall HS marks by 1.0; GPA in semesters 1,2,3,6; HS marks in semesters 1,2,3,6 and OCPPD marks in semesters 2,3. Meanwhile, one unit increase in entrance score was associated with a significant increase in cGPA by 0.01; overall HS by 0.2 marks and overall OCPPD by 0.11 marks. The effect of entrance score was also seen with increase in students’ GPA in semesters 1,2,3,4,6 by at least 0.01, as well as marks for HS in semesters 1,2,3,4,6 and OCPPD in semesters 2,3.ConclusionOur findings support that both PUFR and entrance scores as selection criteria for admission into a medical programme were associated with better academic performances, with PUFR showing a greater mark increase than entrance scores. Meanwhile, MMI showed better academic performance in the patient care module only, inferring that MMI grants a glimpse of candidates’ bedside attitude towards patients.