bluuebunny/crossref_metadata_2025_split huggingface dataset:
High dose rate 192Ir versus high dose rate 60Co brachytherapy: an overview of systematic reviews of clinical responses of gynecological cancers from 1984 to 2020
Authors: Abtahi M , Gholami S , Jassim H H 
Published: August 2021

Abstract

The Purpose. Radioisotope of 192Iradium (192Ir) has a half-life (74 days) and is not easily accessible in developing countries. As a result, by the time source shipment clearance and the customs paperwork are completed, a large proportion of useful activity had already been decayed away. In fact, 60Cobalt (60Co) remote afterloading systems are commercially available by many venders. As a result, it may well become an alternative source to 192Ir and conform many of these challenges. The aim of this study is that to report clinical responses of different types of gynaecological cancers treated with high dose rate (HDR) 192Ir and HDR60Co brachytherapy in order to check whether HDR 60Co could be used as an alternative brachytherapy, source to HDR 192Ir. Materials and Methods. A retrospective study of clinical responses of different types of gynaecological cancers, staged from I to IV according to recommendations of International Federation of Gynaecology and Obstetrics (FIGO), treated by brachytherapy alone, radiotherapy alone (combined brachytherapy and radiotherapy) and combined radiotherapy and chemotherapy (brachytherapy, radiotherapy and chemotherapy) between 1984 and December 2020 was conducted. The patients were treated with external beam radiotherapy 45–51 Gy boosted with HDR 192Ir and HDR 60Co afterloading brachytherapy of 18–30 Gy to point A. The results. The study scrutinized the data of 11086 patients with different types of gynaecological cancers. Most of the patients, 70 percent of them, were diagnosed with gynaecological cancers in stages II and III. For patients treated with 192Ir brachytherapy source 5-years overall survival rate (OS), local control, 2-years, 5-years and 10-years disease free survival (DFS), complications of gastro-intestine (GI) and complications of genito-urinary (GU) were 63.5%, 92%, 72.6%, 64.07%, 43.75%, 3.9% and 5.92%, but for those treated with 60Co they were 57.7%, 86.63%, 82.5%, 53.35%, 43.75%, 4.8% and 3.7%, respectively. Conclusions. The use of HDR 60Co brachytherapy has the capacity to produce overall survival rate and disease control in patients with carcinoma of the gynaecology comparable to that reported for HDR 192Ir brachytherapy. Currently, the toxicity and damage of the normal tissues and radiation-related second cancers are of a similar incidence to that of standard HDR 192Ir brachytherapy. Source exchange frequency is not a serious concern because it requires less frequency of replacement, and commissioning can be accomplished within years; hence, replacing HDR 192Ir with HDR 60Co brachytherapy achieves significant cost saving. Therefore, we recommend that 60Co source ought to be the first choice for low resource radiotherapy setting as it offers economic advantages over 192Ir and have comparable clinical outcomes to that of 192Ir source.
Net zero adaptation—a review of built environment sustainability assessment tools
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Authors: Shuttleworth Amie , MacAskill Kristen 
Published: August 2021

Abstract
In the context of the built environment there has been a greater focus of research and policy on climate mitigation efforts, compared with adaptation. Buildings designed today will likely need upgrades within their lifetime if adaptation is not adequately considered. There is currently no widely adopted system for assessing building adaptation in design and clearer guidance is needed. By way of example, a review of three established, geographically diverse building sustainability assessment tools (BREEAM, Green Star and LEED) demonstrates the extent that adaptation to climate change and mitigation of greenhouse gas emissions have been integrated. Despite recent assessment updates, emphasis on action pertaining to climate issues is heavily weighted towards mitigation; the integration of adaptation considerations is limited and in most cases not mandatory. This state of play in assessment tools is reflective of wider shortfalls in meaningfully addressing climate change risk in asset design. To ensure that asset investment considers climate-related impacts in a holistic manner, better mechanisms for achieving an integrated perspective of mitigation and adaptation are required.
Detection algorithms and attentive points of safety signal using spontaneous reporting systems as a clinical data source
Authors: Noguchi Yoshihiro , Tachi Tomoya , Teramachi Hitomi 
Published: August 2021

Abstract
Continuous evaluation of drug safety is needed following approval to determine adverse events (AEs) in patient populations with diverse backgrounds. Spontaneous reporting systems are an important source of information for the detection of AEs not identified in clinical trials and for safety assessments that reflect the real-world use of drugs in specific populations and clinical settings. The use of spontaneous reporting systems is expected to detect drug-related AEs early after the launch of a new drug. Spontaneous reporting systems do not contain data on the total number of patients that use a drug; therefore, signal detection by disproportionality analysis, focusing on differences in the ratio of AE reports, is frequently used. In recent years, new analyses have been devised, including signal detection methods focused on the difference in the time to onset of an AE, methods that consider the patient background and those that identify drug–drug interactions. However, unlike commonly used statistics, the results of these analyses are open to misinterpretation if the method and the characteristics of the spontaneous reporting system cannot be evaluated properly. Therefore, this review describes signal detection using data mining, considering traditional methods and the latest knowledge, and their limitations.
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking
Authors: Chen Hui , Li Zhao , Feng Sheng , Richard-Greenblatt Melissa , Hutson Emily , Andrianus Stefen , Glaser Laurel J , Rodino Kyle G , Qian Jianing , Jayaraman Dinesh , Collman Ronald G , Glascock Abigail , Bushman Frederic D , Lee Jae Seung , Cherry Sara , Fausto Alejandra , Weiss Susan R , Koo Hyun , Corby Patricia M , Oceguera Alfonso , O’Doherty Una , Garfall Alfred L , Vogl Dan T , Stadtmauer Edward A , Wang Ping 
Published: August 2021

Abstract

Background
High-sensitivity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen assays are desirable to mitigate false negative results. Limited data are available to quantify and track SARS-CoV-2 antigen burden in respiratory samples from different populations.

Methods
We developed the Microbubbling SARS-CoV-2 Antigen Assay (MSAA) with smartphone readout, with a limit of detection of 0.5 pg/mL (10.6 fmol/L) nucleocapsid antigen or 4000 copies/mL inactivated SARS-CoV-2 virus in nasopharyngeal (NP) swabs. We developed a computer vision and machine learning–based automatic microbubble image classifier to accurately identify positives and negatives and quantified and tracked antigen dynamics in intensive care unit coronavirus disease 2019 (COVID-19) inpatients and immunocompromised COVID-19 patients.

Results
Compared to qualitative reverse transcription−polymerase chain reaction methods, the MSAA demonstrated a positive percentage agreement of 97% (95% CI 92%–99%) and a negative percentage agreement of 97% (95% CI 94%–100%) in a clinical validation study with 372 residual clinical NP swabs. In immunocompetent individuals, the antigen positivity rate in swabs decreased as days-after-symptom-onset increased, despite persistent nucleic acid positivity. Antigen was detected for longer and variable periods of time in immunocompromised patients with hematologic malignancies. Total microbubble volume, a quantitative marker of antigen burden, correlated inversely with cycle threshold values and days-after-symptom-onset. Viral sequence variations were detected in patients with long duration of high antigen burden.

Conclusions
The MSAA enables sensitive and specific detection of acute infections and quantification and tracking of antigen burden and may serve as a screening method in longitudinal studies to identify patients who are likely experiencing active rounds of ongoing replication and warrant close viral sequence monitoring.
Segmental assessment of blood flow efficiency in the total cavopulmonary connection using four-dimensional flow magnetic resonance imaging: vortical flow is associated with increased viscous energy loss rate
Authors: Rijnberg Friso M , Juffermans Joe F , Hazekamp Mark G , Helbing Willem A , Lamb Hildo J , Roest Arno A W , Westenberg Jos J M , van Assen Hans C 
Published: August 2021

AbstractAimsTo study flow-related energetics in multiple anatomical segments of the total cavopulmonary connection (TCPC) in Fontan patients from four-dimensional (4D) flow magnetic resonance imaging (MRI), and to study the relationship between adverse flow patterns and segment-specific energetics.Methods and resultsTwenty-six extracardiac Fontan patients underwent 4D flow MRI of the TCPC. A segmentation of the TCPC was automatically divided into five anatomical segments [conduit, superior vena cava (SVC), right/left pulmonary artery (LPA), and the Fontan confluence]. The presence of vortical flow in the pulmonary arteries or Fontan confluence was qualitatively scored. Kinetic energy (KE), viscous energy loss rate, and vorticity were calculated from the 4D flow MRI velocity field and normalized for segment length and/or inflow. Energetics were compared between segments and the relationship between vortical flow and segment cross-sectional area (CSA) with segment-specific energetics was determined. Vortical flow in the LPA (n = 6) and Fontan confluence (n = 12) were associated with significantly higher vorticity (P = 0.001 and P = 0.015, respectively) and viscous energy loss rate (P = 0.046 and P = 0.04, respectively) compared to patients without vortical flow. The LPA and conduit segments showed the highest KE and viscous energy loss rate, while most favourable energetics were observed in the SVC. Conduit CSA inversely correlated with KE (r = −0.614, P = 0.019) and viscous energy loss rate (r = −0.652, P = 0.011).ConclusionsVortical flow in the Fontan confluence and LPA associated with significantly increased viscous energy loss rate. Four-dimensional flow MRI-derived energetics may be used as a screening tool for direct, MRI-based assessment of flow efficiency in the TCPC.
Quality indicators in the management of elderly Chinese patients with atrial fibrillation: a report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry
Authors: Guo Yutao , Kotalczyk Agnieszka , Imberti Jacopo F , Wang Yutang , Lip Gregory Y H ,   ChiOTEAF Registry Investigators
Published: August 2021

Abstract

Aims
To evaluate the quality measures and clinical performance indicators among elderly Chinese patients with atrial fibrillation (AF). The management of patients with AF requires a holistic, multidisciplinary approach. Quality indicators have been proposed to assess the quality of care in ‘real-world’ clinical practice when managing patients with AF.

Methods and results
The Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry is a prospective, observational, large-scale multicentre registry conducted between October 2014 and December 2018 in China. Data were collected at the enrolment and during the follow-up visits by the local investigators. In the ChiOTEAF registry, 14 primary and 8 secondary indicators from six domains of care were assessed. Six thousand four hundred twenty patients who completed the 1-year follow-up were included in the analysis. Median age was 76 years, and the majority of patients was male (60.8%). Overall, 3246 patients (54.8%) were not treated with oral anticoagulants (OACs) appropriate to their risk of stroke; specifically, among those at highest risk of stroke, OACs were prescribed in only 43.3% patients (1258/2905). Among patients with permanent AF, 32 (3.6%) were prescribed antiarrhythmic drugs, and among those with paroxysmal AF, catheter ablation was performed in 20.7%. Patients were overburdened with multi-morbidities, including hypertension, diabetes mellitus, obesity, and sleep apnoea. During 1-year follow-up, 435 deaths (6.8%) and 89 thromboembolic events (1.4%) occurred. Patient-reported outcomes showed that 55% of patients had indicators of reduced quality of life.

Conclusion
Assessment of quality indicators revealed the gaps in AF care among Chinese patients, highlighting the need for a more integrated or holistic approach to AF management.
Engaging in pedagogical translanguaging in a Shanghai EFL high school class
Authors: Zhou Xiaozhou (Emily) 
Published: August 2021

Abstract
Translanguaging and codeswitching are frequently employed in second/foreign language classrooms. Though the differences between these two practices have been examined from a conceptual perspective, the potential of translanguaging as a pedagogical resource has not been empirically addressed. This article opens with a concise comparison of translanguaging and codeswitching, arguing that they offer different analytical and practical advantages in second/foreign language education. Using extracts from a practitioner study conducted in a high school EFL classroom in Shanghai, this paper illustrates how different linguistic and semiotic resources are deployed in a teacher’s and students’ translanguaging practices in order to achieve pedagogical goals, thus demonstrating the possibilities that pedagogical translanguaging encompasses. The paper argues that practitioners should be encouraged to make full use of these resources so as to create arenas of opportunity for the students.
How will Brexit affect the patterns of European agricultural and food exports?
Authors: Cheptea Angela , Huchet Marilyne , Henry Lucile 
Published: August 2021

AbstractWe analyse how Brexit will affect European agrifood trade using a structural gravity model and by comparing the present deal to four alternative scenarios on the UK’s trade policy. European Union (EU) countries will suffer marginal drops in imports, exports and real income, with stronger effects for Ireland. EU exports to the UK will drop by 10 per cent. European products will be redirected to both intra-EU and extra-EU markets and sold at slightly lower prices. Meat products will suffer the largest losses, Ireland being particularly vulnerable due to strong interconnections with British production chains and increased costs for accessing EU and extra-EU markets.
Smoking cessation, but not reduction, reduces cardiovascular disease incidence
Authors: Jeong Su-Min , Jeon Keun Hye , Shin Dong Wook , Han Kyungdo , Kim Dahye , Park Sang Hyun , Cho Mi Hee , Lee Cheol Min , Nam Ki-Woong , Lee Seung Pyo 
Published: August 2021

Abstract

Aims
The aim of this study was to assess the association of smoking cessation and reduction with risk of cardiovascular disease (CVD).

Methods and results
A total of 897 975 current smokers aged ≥40 years who had undergone two consecutive national health examinations (in 2009 and 2011) were included. Participants were classified as quitters (20.6%), reducers I (≥50% reduction, 7.3%), reducers II (20–50% reduction, 11.6%), sustainers (45.7%), and increasers (≥20% increase, 14.5%). During 5 575 556 person-years (PY) of follow-up, 17 748 stroke (3.2/1000 PY) and 11 271 myocardial infarction (MI) (2.0/1000 PY) events were identified. Quitters had significantly decreased risk of stroke [adjusted hazard ratio (aHR) 0.77 95% confidence interval (CI) 0.74–0.81; absolute risk reduction (ARR) −0.37, 95% CI −0.43 to −0.31] and MI (aHR 0.74, 95% CI 0.70–0.78; ARR −0.27, 95% CI −0.31 to −0.22) compared to sustainers after adjustment for demographic factors, comorbidities, and smoking status. The risk of stroke and MI incidence in reducers I (aHR 1.02, 95% CI 0.97–1.08 and aHR 0.99, 95% CI 0.92–1.06, respectively) and reducers II (aHR 1.00, 95% CI 0.95–1.05 and aHR 0.97, 95% CI 0.92–1.04, respectively) was not significantly different from the risk in sustainers. Further analysis with a subgroup who underwent a third examination (in 2013) showed that those who quit at the second examination but had starting smoking again by the third examination had 42–69% increased risk of CVD compared to sustained quitters.

Conclusions
Smoking cessation, but not reduction, was associated with reduced CVD risk. Our study emphasizes the importance of sustained quitting in terms of CVD risk reduction.
Adverse events in patients with a left ventricular assist device: are patient-reported outcomes affected?
Authors: Thompson Jessica Harman , Faulkner Kenneth , Lee Christopher 
Published: August 2021

Abstract

Aims
Left ventricular assist devices (LVAD) are used to treat advanced heart failure, and the use of these devices in ever increasing, with over 19 000 people having had a device. However, during device therapy over 50% of patients will have some type of major adverse event. The aim of this study was to examine whether having a major adverse event, including major infection and major bleed, would alter patient-reported outcomes over time, including depressive symptoms and health-related quality of life.

Methods and results
T-tests and χ2 analyses were used to determine significant differences between patients who had an adverse event and those who did not. Latent curve growth modelling was used to evaluate change over time in those patients with and without and adverse event. The only difference between those with and without an adverse event was pre-implant depressive symptoms and health-related quality of life. The trajectories of both groups were also similar, with only differences at the pre-implant time point.

Conclusion
In response to an adverse event occurring post-LVAD implantation, we found that patient-reported outcomes, including depressive symptoms and health-related quality of life were not significantly impacted.
Extremophilic taxa predominate in a microbial community of photovoltaic panels in a tropical region
Authors: Moura Juliane B , Delforno Tiago P , do Prado Pierre F , Duarte Iolanda C 
Published: August 2021

ABSTRACT
Photovoltaic panels can be colonized by a highly diverse microbial diversity, despite life-threatening conditions. Although they are distributed worldwide, the microorganisms living on their surfaces have never been profiled in tropical regions using 16S rRNA high-throughput sequencing and PICRUst metagenome prediction of functional content. In this work, we investigated photovoltaic panels from two cities in southeast Brazil, Sorocaba and Itatiba, using these bioinformatics approach. Results showed that, despite significant differences in microbial diversity (p &lt; 0.001), the taxonomic profile was very similar for both photovoltaic panels, dominated mainly by Proteobacteria, Bacteroidota and lower amounts of Cyanobacteria phyla. A predominance of Hymenobacter and Methylobacterium-Methylorubrum was observed at the genus level. We identified a microbial common core composed of Hymenobacter, Deinococcus, Sphingomonas, Methylobacterium-Methylorubrum, Craurococcus-Caldovatus, Massilia, Noviherbaspirillum and 1174-901-12 sharing genera. Predicted metabolisms focused on specific genes associated to radiation and desiccation resistance and pigments, were detected in members of the common core and among the most abundant genera. Our results suggested that taxonomic and functional profiles investigated were consistent with the harsh environment that photovoltaic panels represent. Moreover, the presence of stress genes in the predicted functional content was a preliminary evidence that microbes living there are a possibly source of metabolites with biotechnological interest.
nf-LO: A Scalable, Containerized Workflow for Genome-to-Genome Lift Over
Authors: Talenti Andrea , Prendergast James 
Published: August 2021

Abstract
The increasing availability of new genome assemblies often comes with a paucity of associated genomic annotations, limiting the range of studies that can be performed. A common workaround is to lift over annotations from better annotated genomes. However, generating the files required to perform a lift over is computationally and labor intensive and only a limited number are currently publicly available.
Here we present nf-LO (nextflow-LiftOver), a containerized and scalable Nextflow pipeline that enables lift overs within and between any species for which assemblies are available. nf-LO will consequently facilitate data interpretation across a broad range of genomic studies.
Cold Survival and Its Molecular Mechanisms in a Locally Adapted Nematode Population
Authors: Wang Wenke , Flury Anna G , Garrison Jennifer L , Brem Rachel B 
Published: August 2021

Abstract
Since Darwin, evolutionary biologists have sought to understand the drivers and mechanisms of natural trait diversity. The field advances toward this goal with the discovery of phenotypes that vary in the wild, their relationship to ecology, and their underlying genes. Here, we established resistance to extreme low temperature in the free-living nematode Caenorhabditis briggsae as an ecological and evolutionary model system. We found that C. briggsae strains of temperate origin were strikingly more cold-resistant than those isolated from tropical localities. Transcriptional profiling revealed expression patterns unique to the resistant temperate ecotype, including dozens of genes expressed at high levels even after multiple days of cold-induced physiological slowdown. Mutational analysis validated a role in cold resistance for seven such genes. These findings highlight a candidate case of robust, genetically complex adaptation in an emerging model nematode, and shed light on the mechanisms at play.
CLAMP regulates zygotic genome activation in Drosophila embryos
Authors: Colonnetta Megan M , Abrahante Juan E , Schedl Paul , Gohl Daryl M , Deshpande Girish 
Published: August 2021

Abstract
Embryonic patterning is critically dependent on zygotic genome activation (ZGA). In Drosophila melanogaster embryos, the pioneer factor Zelda directs ZGA, possibly in conjunction with other factors. Here, we have explored the novel involvement of Chromatin-Linked Adapter for MSL Proteins (CLAMP) during ZGA. CLAMP binds thousands of sites genome-wide throughout early embryogenesis. Interestingly, CLAMP relocates to target promoter sequences across the genome when ZGA is initiated. Although there is a considerable overlap between CLAMP and Zelda binding sites, the proteins display distinct temporal dynamics. To assess whether CLAMP occupancy affects gene expression, we analyzed transcriptomes of embryos zygotically compromised for either clamp or zelda and found that transcript levels of many zygotically activated genes are similarly affected. Importantly, compromising either clamp or zelda disrupted the expression of critical segmentation and sex determination genes bound by CLAMP (and Zelda). Furthermore, clamp knockdown embryos recapitulate other phenotypes observed in Zelda-depleted embryos, including nuclear division defects, centrosome aberrations, and a disorganized actomyosin network. Based on these data, we propose that CLAMP acts in concert with Zelda to regulate early zygotic transcription.