bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue Metabolites of Large Yellow Croaker and Construction of Swimming Model
Authors: Chai Ruoyu , Yin Heng , Huo Runming , Shui Xiaomei , Wang Hanying , Huang Ling , Wang Ping 
Published: December 2021

AbstractA trend in large yellow croaker (Larimichthys crocea) aquaculture is to establish new production sites that are suitable for extreme weather conditions. However, continuous and strong currents can harm fish welfare. To determine the location of the net cage, it is necessary to assess the swimming ability of large yellow croaker. Currently, our research on large yellow croakers is focusing on behavior analysis. This article investigates the effect of swimming large yellow croakers on metabolites in the body by examining the preferred speed of the group and the endurance swimming ability of single-tailed fish. We evaluated the factors that influence the large yellow croaker’s swimming fatigue by quantifying the content of metabolites and constructed the endurance swimming model using those results. Various results showed large yellow croaker populations tend to grow in low-velocity environments, and this matches their traditional habitat. The samples were taken at different swimming times at a flow rate of 0.35 m/s. According to the results of the metabolite content determination, blood glucose levels is closely related to swimming ability in large yellow croakers. The content of liver glycogen, which regulates blood glucose concentration, decreases in a certain linear relationship. The endurance swimming model of large yellow croaker was constructed according to the changes of liver glycogen content. The goals of this article are to provide a deeper understanding of the physiological characteristics of large yellow croaker swimming, and to provide a reference for choosing fishing and cage sites for large yellow croaker.
Alcohol intake and hypertensive disorders of pregnancy: a negative control analysis in the ALSPAC cohort
Authors: Martin Florence Z , Fraser Abigail , Zuccolo Luisa 
Published: December 2021

AbstractIntroductionAlcohol intake increases blood pressure, yet estimates of associations between maternal intake and hypertensive disorders of pregnancy (HDP) are sparse and range from null to a protective effect. Here we estimated the association of maternal drinking during pregnancy with preeclampsia and gestational hypertension (separately and jointly, as HDP). We used partner’s alcohol intake as a negative control exposure, beverage type-specific models, and a range of sensitivity analyses to strengthen causal inference and reduce the influence of bias.MethodsWe performed a prospective cohort study using data on self-reported alcohol intake in the UK Avon Longitudinal Study of Parents And Children (ALSPAC) and HDP ascertained from obstetric notes. Multivariable multinomial regression models were adjusted for confounders and mutually adjusted for partner’s or maternal alcohol intake in the negative control analysis. We also performed a beverage type analysis of the effect of beer and wine separately on HDP risk, due to different social patterning associated with different drinks. Sensitivity analyses assessed the robustness of results to assumptions of no recall bias, no residual confounding, and no selection bias.ResultsOf the 8,999 women eligible for inclusion, 1,490 developed HDP (17%). Both maternal and partner’s drinking were associated with decreased HDP odds (mutually adjusted odds ratio 0.86, 95% confidence interval 0.77 to 0.96, P-value=0.008 and 0.82, 0.70 to 0.97, P=0.018, respectively). We demonstrate the validity of the negative control analyses using the same approach for smoking as the exposure. This confirmed an inverse association for maternal but not partner’s smoking, as expected. Estimates were more extreme for increasing levels of wine intake compared to increasing levels of beer. Multiple sensitivity analyses did not alter our conclusions.ConclusionWe observed an inverse relationship between alcohol intake during pregnancy and risk of HDP for both maternal and, more surprisingly, partner’s drinking. We speculate that this is more likely to be due to common environmental exposures shared between pregnant women and their partners, rather than a true causal effect. This warrants further investigation using different study designs, including Mendelian randomisation.
Study of association of migraine susceptibility genes with common migraine in 200,000 exome-sequenced UK Biobank participants
Authors: Markel Katherine Alexis , Curtis David 
Published: December 2021

AbstractBackgroundA number of genes have been implicated in rare familial syndromes which have migraine as part of their phenotype but these genes have not previously been implicated in the common form of migraine.MethodsAmong exome-sequenced participants in the UK Biobank we identified 7,194 migraine cases with the remaining 193,433 participants classified as controls. We investigated ten genes previously reported to be implicated in conditions with migraine as a prominent part of the phenotype and carried out gene and variant based tests for association.ResultsWe found no evidence for association of these genes or variants with the common form of migraine seen in our subjects. In particular, a frameshift variant in KCNK18, F139Wfs*24, which had been shown to segregate with migraine with aura in a multiply affected pedigree was found in 196 (0.10%) controls as well as in 10 (0.14%) cases (χ2 = 0.96, 1 df, p = 0.33).ConclusionsSince there is no other reported evidence to implicate KCNK18, we conclude that this gene and its product, TRESK, should no longer be regarded as being involved in migraine aetiology. Overall, we do not find that rare, functional variants in genes previously implicated to be involved in familial syndromes including migraine as part of the phenotype make a contribution to the commoner forms of migraine observed in this population.
Optimization of surface quality and machining time in micro-milling of glass
Authors: Dinc Ali , Mamedov Ali 
Published: December 2021

Purpose
Glass is a brittle material produced from silica, which has fine material properties, Owing to its sophisticated material properties, glass has found wide application in various high-technological fields such as aviation, aerospace, communication, optics, biomedical and electronics. However, glass is known as difficult to machine material because of its tendency to brittle fracture during machining. This paper aims to investigate the effects of cutting parameters on surface quality and machining time during micro-milling of brittle glass components.

Design/methodology/approach
A comprehensive genetic algorithm-based optimization strategy is used for selection of process parameters such as cutting speed, feed rate and depth of cut. Effectiveness of the proposed strategy is validated by conducting micro-milling cutting experiments on soda-lime glass material.

Findings
Results showed that the generated surface quality drastically decrease with increase in the amount of removed material. Lower depth of cut and feed rate result in less amount of cracks formed on machined surface. Also, it is observed that the increase in cutting speed results in better surface quality. Having desired surface quality in shorter machining time directly reduces energy consumed during manufacturing, which is reducing environmental impact of glass parts.

Originality/value
The novelty of this research work lies in simultaneously considering the effects of cutting speed, feed rate, depth of cut on surface quality and machining time for micro-milling operation of brittle glass material. The model is able to find optimum process parameters for high surface quality and minimum machining time.
Managing BPM life cycle transition risks in a small educational company to support change management
Authors: Souza Larissa Ane Hora de , Carvalho Victor Diogho Heuer de , Santos Roberio José Rogério dos , Silva Jonhatan Magno Norte da 
Published: December 2021

PurposeThis article aims to present a methodology applied to the transition between the “as-is” and “to-be” stages of the Business Process Management (BPM) life cycle, supporting its implementation and maintenance for the organizational stability, using techniques from Operations Research and Information and Decision Theories, applied by a gamified system.Design/methodology/approachThe study used Design Science Research, considering the following methodological elements: (1) artifact model, after initial analysis of the organization; (2) problem relevance, incorporating components to the Markov transition matrix and the integer programming model for resource optimization; (3) model evaluation, establishing mechanisms to validate the methodology created; (4) research contributions, showing benefits found; (5) systematic approach, detailing methods used; (6) model's research process, revealing the means for execution; and (7) final presentation of results.FindingsAfter planning three scenarios for the company, containing zero, one or two implemented processes, the matrix of states in the Markov chain effectively identified the states of greater and lesser transition uncertainty. At the same time, the optimization model guided the organization toward a stable change in its operational and financial areas.Practical implicationsThe company's planning capacity has increased, as its managers now have a methodology to promote rational decisions about the development of plans. Before, managers believed that the methodology used was only for large companies. However, this view changed with the results, showing a structured view of the ability to absorb new customers, relocate established ones, increase the comfort level for employees and increase profitability for the company's business.Originality/valueThe study showed that the combination of techniques opens a new perspective to the incorporation of BPM in organizations, allows a smooth change between the current and future state, making it possible to predict the evolution of transition scenarios.
Congestion management in deregulated power system using adaptive moth swarm optimization
Authors: Ramaporselvi R. , Geetha G. 
Published: December 2021

PurposeThe purpose of this paper is to enhance the line congestion and to minimize power loss. Transmission line congestion is considered the most acute trouble during the operation of the power system. Therefore, congestion management acts as an effective tool in using the available power without breaking the system hindrances or limitations.Design/methodology/approachOver the past few years, determining the optimal location and size of the devices have pinched a great deal of consideration. Numerous approaches have been established to mitigate the congestion rate, and this paper aims to enhance the line congestion and minimize power loss by determining the compensation rate and optimal location of a thyristor-switched capacitor (TCSC) using adaptive moth swarm optimization (AMSO) algorithm.FindingsAn AMSO algorithm uses the performances of moth flame and the chaotic local search-based shrinking scheme of the bacterial foraging optimization algorithm. The proposed AMSO approach is executed and discussed for the IEEE-30 bus system for determining the optimal location of single TCSC and dual TCSC.Originality/valueIn addition to this, the proposed algorithm is compared with various other existing approaches, and the results thus obtained provide better performances than other techniques.
Mental health and COVID-19 perceptions in a predominant black population in the Eastern Caribbean: an exploratory study of residents of Barbados
Authors: King Jolene , Devonish Dwayne 
Published: December 2021

Purpose
The purpose of this study is to examine the mental health challenges of residents of Barbados during the COVID-19 pandemic and the relationships between residents’ demographics, COVID-19 perceptions and mental health outcomes.

Design/methodology/approach
The study surveyed 450 predominantly Black Caribbean respondents to examine their mental ill-health on the various dimensions of the General Health Questionnaire (GHQ)-28 measure and the relationships with demographics and COVID-19 perceptions.

Findings
Confirmatory factor analysis confirmed the four-factor model solution of GHQ-28 over the single factor solution. Barbadians were generally mild in their mental ill-health on the somatic symptoms, social dysfunction and severe depression dimensions but were at least moderately strained on the anxiety and insomnia dimensions. Younger and unemployed Barbadian respondents reported more adverse mental health outcomes, and perceived severity of COVID-19 infection significantly predicted three of the four dimensions of mental distress (excluding severe depression).

Research limitations/implications
The study used a cross-sectional self-report survey research design which does not permit causal inferences. Further research is advised to ascertain the longitudinal effects of COVID-19 perceptions over time on mental health outcomes.

Practical implications
The study’s findings suggest the need for nation-wide, multi-stakeholder interventions or approaches in responding mental health challenges of the population during this crisis.

Originality/value
The study was the first to examine the mental health outcomes, using GHQ-28, in a small Caribbean country – which represents an underserved space in mental health research. It is the first to empirically examine the relationship between COVID-19 perceptions of Afro-Caribbean people in this region and their resultant mental health outcomes.
Identification of printed circuit boards mechanical properties using response surface methods
Authors: Gharaibeh Mohammad 
Published: December 2021

Purpose
This study aims to discuss the determination of the unknown in-plane mechanical material properties of printed circuit boards (PCBs) by correlating the results from dynamic testing and finite element (FE) models using the response surface method (RSM).

Design/methodology/approach
The first 10 resonant frequencies and vibratory mode shapes are measured using modal analysis with hammer testing experiment, and hence, systematically compared with finite element analysis (FEA) results. The RSM is consequently used to minimize the cumulative error between dynamic testing and FEA results by continuously modifying the FE model, to acquire material properties of PCBs.

Findings
Great agreement is shown when comparing FEA to measurements, the optimum in-plane material properties were identified, and hence, verified.

Originality/value
This paper used FEA and RSMs along with modal measurements to obtain in-plane material properties of PCBs. The methodology presented here can be easily generalized and repeated for different board designs and configurations.
Significance of fabrication parameters over the mechanical and metallurgical properties of AMMC joint formed by microwave hybrid heating
Authors: Singh Jagbir , Kataria Mukul , Kumar Vishesh , Jawalkar Chandrashekhar , Belokar Rajendra Madhukar 
Published: December 2021

Purpose
The purpose of the study is to fabricate a joint between two aluminium metal matrix composites using microwave hybrid heating (MHH).

Design/methodology/approach
Taguchi design of experiments was applied to conduct the experimental study. The mechanical properties such as ultimate tensile strength, micro-hardness and porosity were studied. Grey Relational Analysis was applied to understand the significance of fabrication parameters of best performing sample. The dominant factor of fabrication was analysed using ANOVA. The best performance sample was further characterised using X-ray diffraction and field emission scanning electron microscopy. Energy dispersive X-ray was used to analyse the elemental composition of the sample.

Findings
The Aluminium Metal Matrix Composite (AMMC) joint was successfully fabricated using MHH. The mechanical properties were mainly influenced by the fabrication factor of exposure time.

Originality/value
The formation of AMMC joint using MHH might explore the way for the industries in the field of joining.
Development and validation of a prediction model for bothersome stress urinary incontinence after prolapse surgery: A retrospective cohort study
Authors: Oh Sumin , Lee Sungyoung , Hwang Woo Yeon , Suh Dong Hoon , Jeon Myung Jae 
Published: December 2021

AbstractObjectiveTo develop and validate a prediction model for bothersome stress urinary incontinence after prolapse surgery and to compare it with an existing clinical prediction model (CUPIDO model).DesignRetrospective cohort study.SettingTwo tertiary hospitals in South Korea.PopulationA total of 1142 patients who underwent prolapse surgery with or without a concomitant midurethral sling.MethodsTo construct a prediction model, we performed logistic regression using both exhaustive and stepwise variable selection, validating the model both internally and externally.Main Outcome MeasuresBothersome stress urinary incontinence defined as the presence of bothersome symptoms of stress urinary incontinence and/or subsequent continence procedure one year after surgery.ResultsPostoperative bothersome stress urinary incontinence occurred in 10% of patients. A model containing six predictors (age, diabetes mellitus, subjective urinary incontinence, prolapse reduction stress test result, type of prolapse surgery, and a concomitant midurethral sling) showed excellent performance for predicting bothersome stress urinary incontinence (area under the curve 0.74, 95% confidence interval 0.62–0.86) and outperformed the CUPIDO model (area under the curve 0.63, 95% confidence interval 0.49–0.76; DeLong’s test P = 0.014).ConclusionsThis prediction model might be a useful tool to guide patient decision making regarding a concomitant continence procedure at the time of prolapse surgery. The predictive value of this model needs to be validated further in cohorts with different characteristics.Tweetable AbstractThe proposed prediction model for bothersome stress urinary incontinence after prolapse surgery outperforms an existing model.
Differentiation between spinal subchondral bone metastasis with focal pathologic endplate fracture and oedematous Schmorl’s node
Authors: Oh Eunsun , Kim Hyun‐joo , Kwon Jong Won , Yoon Young Cheol , Kim Hyun Su 
Published: December 2021

AbstractIntroductionWe aimed to identify imaging‐based findings that can differentiate between spinal subchondral bone metastasis with focal pathologic endplate fracture and oedematous Schmorl’s nodes that have been histopathologically confirmed.MethodsBetween March 2010 and April 2016, 11 patients who had undergone spinal magnetic resonance (MR) imaging or computed tomography (CT) with final radiologic reports that included ‘subchondral bone metastasis with focal pathologic endplate fracture’ or ‘edematous Schmorl’s node’ and had also undergone percutaneous imaging‐guided spinal biopsies were included. Two radiologists retrospectively evaluated the following imaging features in consensus: size, location, presence of sclerotic margin, presence of intralesional or perilesional enhancement and opposite endplate enhancement of the involved disc, presence of disc height loss and presence of metabolic uptake at a corresponding lesion on nuclear medicine imaging.ResultsA total of 11 patients, including six patients with spinal subchondral bone metastasis with focal pathologic endplate fracture and five patients with oedematous Schmorl’s nodes, were included in this study (median age, 58 years; range, 50–63 years; six men). Sclerotic margin (P = 0.002) and enhancement on the opposite endplate of the involved disc (P = 0.047) were significantly different between oedematous Schmorl’s node and subchondral bone metastasis with focal pathologic endplate fracture.ConclusionSclerotic margin and enhancement on the opposite endplate of the involved disc suggest oedematous Schmorl’s node rather than subchondral bone metastasis with focal pathologic endplate fracture. Decreased disc height is likely to be an oedematous Schmorl’s node rather than subchondral bone metastasis with focal pathologic endplate fracture.
Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open‐label, long‐term extension study with up to 7.0 years of treatment
Authors: Sandborn William J. , Lawendy Nervin , Danese Silvio , Su Chinyu , Loftus Edward V. , Hart Ailsa , Dotan Iris , Damião Adérson O. M. C. , Judd Donna T. , Guo Xiang , Modesto Irene , Wang Wenjin , Panés Julian 
Published: December 2021

SummaryBackgroundTofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We present final data from OCTAVE Open, an open‐label, long‐term extension study.AimsThe primary objective of OCTAVE Open was to assess the safety and tolerability of long‐term tofacitinib in patients with ulcerative colitis; evaluating efficacy was a secondary objective.MethodsEligible patients included OCTAVE Induction 1&2 non‐responders and OCTAVE Sustain completers/treatment failures. Patients in remission at OCTAVE Open baseline received tofacitinib 5 mg b.d.; all others received 10 mg b.d. Incidence rates (unique patients with events/100 patient‐years) for adverse events of special interest were calculated; ≤7.0 years of observation. Efficacy endpoints derived from Mayo score were reported ≤36 months (last scheduled endoscopy visit).ResultsIn OCTAVE Open, 769 of 944 patients (81.5%) initially received tofacitinib 10 mg b.d. Among all patients (2440.8 patient‐years of exposure), incidence rates (IRs; 95% confidence intervals) for deaths and adverse events of special interest were: deaths, 0.25 (0.09‐0.54); serious infections, 1.61 (1.14‐2.20); herpes zoster (non‐serious and serious), 3.16 (2.47‐3.97); opportunistic infections, 0.87 (0.54‐1.33); major adverse cardiovascular events, 0.16 (0.04‐0.42); malignancies (excluding non‐melanoma skin cancer), 1.03 (0.67‐1.52); non‐melanoma skin cancer, 0.75 (0.45‐1.19); deep vein thrombosis, 0.04 (0.00‐0.23); pulmonary embolism, 0.21 (0.07‐0.48). At Month 36, 66.9% and 40.3% showed clinical response, 64.6% and 37.1% had endoscopic improvement, and 58.9% and 33.7% maintained or achieved remission, with tofacitinib 5 and 10 mg b.d. respectively.ConclusionTofacitinib demonstrated consistent safety up to 7.0 years. Data collected up to Month 36 support long‐term efficacy beyond the 52‐week maintenance study.
The myth of organization autonomy: Social workers’ salary under the lump sum grant subvention system in Hong Kong
Authors: Dai Haijing , Jiang Niantao , Li Ruobing 
Published: December 2021

AbstractAdopting the principles of managerialism, the Lump Sum Grant Subvention System in Hong Kong grants service organizations autonomy to deploy resources. Using organization‐ and individual‐level survey data, this article examines the salaries of social workers under the managerialist subvention system and investigates its impacts on frontline service professionals. We found that when service organizations adopted flexible employment terms to hire social workers, they offered lower minimum wage. Smaller organizations, which are often believed to benefit more from the system, paid social workers lower minimum wage. When individual social workers made use of flexible employment terms and switched their jobs in the welfare sector, there was no evidence that their income levels would be raised—on the contrary, switching jobs for three or more times would in fact lower their income levels. Furthermore, while the system encouraged social workers to get more involved in management work, there was no evidence that increasing work hours on management‐related work would increase the income of social workers. As organizational autonomy does not necessarily result in income justice for frontline social workers, clear guidelines, supervision, and policy interventions in the management of service organizations are still needed in social service planning and delivery.