bluuebunny/crossref_metadata_2025_split huggingface dataset:
The PCT to Albumin Ratio Predicts Mortality in Patients With Acute Kidney Injury Caused by Abdominal Infection-Evoked Sepsis
Authors: Chen Lijuan , Wu Xiaoli , Qin Haiyan , Zhu Hongchao 
Published: June 2021

Purpose: Considerable evidence suggests that inflammation and malnutrition are common in patients with acute kidney injury (AKI) and correlated with mortality of various diseases. Despite this, few studies have reported the underlying predictive effects of inflammatory and nutritional markers in combination on the mortality of AKI patients. Herein, we aimed to explore the values of PCT and CRP as well as the ratios of PCT/Alb and CRP/Alb in the poor prognosis of patients with sepsis-induced AKI.Patients and Methods: A total of 171 patients with AKI, caused by abdominal infection-evoked sepsis, were retrospectively studied and divided into a survival group (107 cases) and a non-survival group (64 cases). Univariate analysis was used to compare the clinical data of the two groups. Multivariate logistic regression analysis was used to analyze the independent risk factors of poor prognosis in patients with sepsis-induced AKI. The ROC curve was used to evaluate the diagnostic value of PCT, CRP, PCT/Alb, and CRP/Alb in the poor prognosis of patients with sepsis-induced AKI.Results: Univariate analysis revealed that the values of PCT, CRP, CRP/Alb, and PCT/Alb were significantly different between AKI survival and non-survival groups, and further analysis found that PCT and PCT/Alb were independent risk factors for poor prognosis in patients with sepsis-induced AKI after adjusting with age and gender. Of note, the predictive accuracy (0.864 vs. 0.807), specificity (83.2 vs. 69.2), and sensitivity (79.7 vs. 76.6) of PCT/Alb were all higher than that of the simple PCT.Conclusions: The ratio of PCT to Alb is an independent risk factor possessing a robust and accurate risk assessment for the poor prognosis of patients with sepsis-induced AKI, and it offers the potential to improve the management of this type of disease and a lower resultant mortality.
Changes of Radiation Treatment Concept Based on 68Ga-PSMA-11-PET/CT in Early PSA-Recurrences After Radical Prostatectomy
Authors: Bottke Dirk , Miksch Jonathan , Thamm Reinhard , Krohn Thomas , Bartkowiak Detlef , Beer Meinrad , Bolenz Christian , Beer Ambros J. , Prasad Vikas , Wiegel Thomas 
Published: June 2021

Background and PurposeSalvage radiotherapy (SRT) is the main potentially curative treatment option for prostate cancer patients with post-prostatectomy PSA progression. Improved diagnostics by positron emission tomography/computed tomography (PET/CT) can lead to adjustments in treatment procedures (e.g. target volume of radiotherapy, androgen deprivation therapy). We analyzed the impact of 68Ga-PSMA-11-PET/CT on the target volume in early biochemical recurrence (PSA up to 0.5 ng/ml).Patients and MethodsWe retrospectively analyzed 76 patients with biochemical recurrence after radical prostatectomy in whom SRT was planned after 68Ga-PSMA-11-PET/CT. All patients had a PSA ≤0.5 ng/ml. An experienced radiation oncologist determined the radiotherapy concept, first with consideration of the PET/CT, second hypothetically based on the clinical and pathological features excluding PET/CT results.ResultsWithout considering the PET/CT, all 76 patients would have been assigned to RT, 60 (79%) to the bed of the prostate and seminal vesicles alone, and 16 (21%) also to the pelvic lymph nodes because of histopathologic risk factors. Uptake indicative for tumor recurrence in 68Ga-PSMA-11-PET/CT was found in 54% of the patients. The median pre-PET/CT PSA level was 0.245 ng/ml (range 0.07–0.5 ng/ml). The results of the PET/CT led to a change in the radiotherapeutic target volume in 21 patients (28%). There were major changes in the target volume including the additional irradiation of lymph nodes or the additional or exclusive irradiation of bone metastases in 13 patients (17%). Minor changes including the additional irradiation of original seminal vesicle (base) position resulted in eight patients (11%).ConclusionUsing 68Ga-PSMA-11-PET/CT for radiation planning, a change in the treatment concept was indicated in 28% of patients. With PET/CT, the actual extent of the tumor can be precisely determined even with PSA values of ≤0.5 ng/ml. Thus, the treatment concept can be improved and individualized. This may have a positive impact on progression free survival. Our results warrant further prospective studies.
Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis
Authors: Li Sha , Wang Chenghai , Zhang Xiaxia , Su Wen 
Published: May 2021

BackgroundCholestasis is a pathological condition involving obstruction of bile secretion and excretion that results in hepatotoxicity, inflammation, fibrosis, cirrhosis, and eventually liver failure. Common bile duct ligation (BDL) model is a well-established murine model to mimic cholestatic liver fibrosis. We previously reported that cytochrome P450 omega-hydroxylase 4a14 (Cyp4a14) plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD)-related fibrosis. The goal of this study was to determine the role of Cyp4a14 in cholestatic-induced liver fibrosis.MethodsC57BL/6 mice were subjected to BDL for 14 days, and Cyp4a14 mRNA and protein levels were examined and compared with those of the sham group. Cyp4a14 knockout mice and adeno-associated virus (AAV)-mediated overexpression of Cyp4a14 in C57BL/6 mice underwent BDL and liver histology, and key fibrosis markers were examined.ResultsBoth hepatic Cyp4a14 mRNA and protein levels were markedly reduced in BDL liver compared with the time-matched sham group. Cyp4a14 gene-deficient mice aggravates whereas its overexpression alleviates BDL-induced hepatic fibrosis, which were determined by liver function, liver histology, and levels of key fibrotic markers including α-smooth muscle actin (α-SMA), transforming growth factor-β1 (TGF-β1), and collagen 1a2 (Col1a2).ConclusionCyp4a14 exerts a contrasting role in different hepatic fibrosis models. Strategies that enhance Cyp4a14 activity may be potential strategies to cholestatic related liver fibrosis.
Benevolence – Associations With Stress, Mental Health, and Self-Compassion at the Workplace
Authors: Andersson Christina , Stenfors Cecilia U. D. , Lilliengren Peter , Einhorn Stefan , Osika Walter 
Published: June 2021

ObjectiveBenevolence is an emerging concept in motivation theory and research as well as in on pro-social behavior, which has stimulated increasing interest in studying factors that impair or facilitate benevolence and effects thereof. This exploratory study examines the associations between benevolence, stress, mental health, self-compassion, and satisfaction with life in two workplace samples.MethodsIn the first study n = 522 (38% = female, median age = 42) participants answered questionnaires regarding self-reported stress symptoms (i.e., emotional exhaustion), depressive symptoms and benevolence. In the second study n = 49 (female = 96%) participants answered questionnaires regarding perceived stress, self-compassion, anxiety, depression symptoms, and benevolence.ResultsIn study 1, measures of emotional exhaustion (r = −0.295) and depression (r = −0.190) were significantly negatively correlated with benevolence. In study 2, benevolence was significantly negatively correlated with stress (r = −0.392) and depression (r = −0.310), whereas self-compassion (0.401) was significantly positively correlated with benevolence. While correlations were in expected directions, benevolence was not significantly associated with Satisfaction with Life (r = 0.148) or anxiety (r = −0.199) in study 2.ConclusionSelf-assessed benevolence is associated with levels of perceived stress, exhaustion, depression, and self-compassion. Future studies are warranted on how benevolence is related to stress and mental ill health such as depression and anxiety, and if benevolence can be trained in order to decrease stress and mental ill health such as depression and anxiety in workplace settings.
Intranasal Ketamine for Depression in Adults: A Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials
Authors: An Dongjiao , Wei Changwei , Wang Jing , Wu Anshi 
Published: June 2021

BackgroundThere is growing interest in glutamatergic agents as a treatment for depression, especially intranasal ketamine, which has become a hot topic in recent years. We aim to assess the efficacy and safety of intranasal ketamine in the treatment of major depressive disorder (MDD), especially treatment-resistant depression (TRD).MethodsWe searched Medline, EMBASE, and the Cochrane Library until April 1, 2020 to identify double-blind, randomized controlled trials with allocation concealment evaluating intranasal ketamine in major depressive episodes. Clinical remission, response, and depressive symptoms were extracted by two independent raters. The outcome measures were Montgomery–Asberg Depression Rating Scale (MADRS) score improved from baseline, clinical response and remission, dissociative symptoms, and common adverse events. The analyses employed a random-effects model.ResultsData were synthesized from five randomized controlled trials (RCTs) employing an intranasal esketamine and one RCT employing intranasal ketamine, representing 840 subjects in parallel arms, and 18 subjects in cross-over designs (n = 858 with MDD, n = 792 with TRD). The weighted mean difference of MADRS score was observed to decrease by 6.16 (95% CI 4.44–7.88) in 2–4 h, 9.96 (95% CI 8.97–10.95) in 24 h, and 4.09 (95% CI 2.18–6.00) in 28 day. The pooled relative risk (RR) was 3.55 (95% CI 1.5–8.38, z = 2.89, and p &lt; 0.001) for clinical remission and 3.22 (95% CI 1.85–5.61, z = 4.14, and p &lt; 0.001) for clinical response at 24 h, while the pooled RR was 1.7 (95% CI 1.28–2.24, z = 3.72, and p &lt; 0.001) for clinical remission and 1.48 (95% CI 1.17–1.86, z = 3.28, and p &lt; 0.001) for clinical response at 28 day. Intranasal ketamine was associated with the occurrence of transient dissociative symptoms and common adverse events, but no persistent psychoses or affective switches.ConclusionOur meta-analysis suggests that repeated intranasal ketamine conducted a fast-onset antidepression effect in unipolar depression, while the mild and transient adverse effects were acceptable.Systematic Review RegistrationPROSPERO, CRD42020196856.
Aceitação e consumo de alimentos irradiados em Goiânia-GO / Acceptance and consumption of irradiated foods in Goiânia-GO
Authors: Rocha Andressa Feitosa , Ferreira Natália Nóbrega , De Souza Adriana Régia Marques , Flores Isadora Jacomini , Arthur Valter 
Published: May 2021

Os alimentos se deterioram com facilidade, por isso é necessário aplicar algumas técnicas de conservação para aumentar a vida útil dos mesmos e garantir que cheguem aos consumidores de forma segura. A irradiação de alimentos é uma dessas técnicas que utiliza doses controladas de radiação ionizante, não afetando as propriedades nutricionais e sensoriais do produto. Apesar desta tecnologia ser aprovada e regulamentada por diversos órgãos nacionais e internacionais, muitos são os obstáculos enfrentados para a comercialização e aceitação de alimentos irradiados no Brasil. O objetivo do trabalho foi verificar a aceitação e consumo de alimentos irradiados pelos consumidores da cidade de Goiânia – Goiás. Foi aplicado um questionário composto por 12 questões e o entrevistado respondeu as questões de um a onze sem qualquer explicação prévia sobre a irradiação de alimentos, em seguida foi dada uma breve explicação sobre o assunto e então a questão 12 era feita. O questionário foi aplicado na comunidade externa ao redor do campus Samambaia da Universidade Federal de Goiás (UFG), Restaurante Universitário da UFG e no parque Flamboyant, situados na cidade de Goiânia. Os dados foram tabulados e analisados por meio de gráficos com o software Excel e algumas questões foram submetidas à análise do teste do qui-quadrado (5% de significância) em relação às questões de faixa etária, sexo, escolaridade e renda. Das pessoas entrevistadas, 90% responderam não ter nenhum conhecimento sobre o que é irradiação de alimentos e 10% afirmaram conhecer a tecnologia. Quando perguntados se consumiriam um alimento sabendo que ele passou pelo processo de irradiação 45% responderam que não consumiriam, 27% ficaram em dúvida e 28% afirmaram que sim. Após o esclarecimento sobre alimentos irradiados, 89% das pessoas afirmaram que consumiriam alimentos irradiados, mostrando que a falta de informação é o maior fator para a não aceitação e consumo de alimentos irradiados. Sendo necessária uma melhor exploração das informações relacionada a este tema, para que os consumidores se tornem mais abertos para conhecer e consumir esses produtos de forma consciente.
Interferência dos metais sódio, magnésio e cálcio na determinação de urânio em amostras de águas tratadas pela técnica de espectrometria óptica por plasma indutivamente acoplado / Interference of sodium, magnesium and calcium metals in the determination of uranium in treated water samples by the optical spectrometry inductively coupled plasma technique
Authors: De Freitas Jorge Tadeu , Tavares Joseina Moutinho , Luz Sandra Regina Novaes de Oliveira , Baptista Antônio Jorge R. 
Published: May 2021

Diante dos riscos que o Urânio apresenta à saúde dos seres humanos e ao Meio Ambiente, o Ministério da Saúde e o Conselho Nacional de Meio Ambiente do Brasil estabeleceram limites normativos para a concentração de Urânio em águas tratadas, subterrâneas e mananciais nas seguintes legislações: Portaria MS Nº 2914/2011, Resolução CONAMA 396/2008 e Resolução CONAMA 357/2005, respectivamente. Internacionalmente, já existe a preocupação com Urânio, por diversos órgãos reguladores e agências de saúde, como a Organização Mundial de Saúde (OMS) e a Agência de Proteção Ambiental dos Estados Unidos (EPA). Com o objetivo de se atender aos baixos limites analíticos preconizados na Legislação, é necessário o desenvolvimento de metodologias analíticas sensíveis e confiáveis para a determinação de Urânio. A técnica da Espectrometria Óptica por Plasma Indutivamente Acoplado (ICP OES) tem sido muito empregada na análise de amostras de águas, por apresentar maior sensibilidade do que a técnica por Absorção Atômica por Chama (FAAS), boa relação custo benefício em relação à Espectrometria de Massa com Plasma Indutivamente Acoplado (ICP-MS) e dispensar o tratamento prévio no caso das amostras de água potável.Neste trabalho foi desenvolvido um método analítico para a determinação de Urânio em amostras de águas tratadas pela técnica de ICP OES, com um equipamento com tocha de vista axial e sistema de cone para eliminação da zona fria do plasma. Também foi investigada a interferência dos metais Sódio, Magnésio e Cálcio, conhecidos como Elementos Facilmente Ionizáveis (EIE). Estes metais estão presentes em concentrações elevadas em regiões de clima seco e semi-árido ou de áreas de captação de água de mananciais que sofrem influência de águas marinhas. Para este estudo foram empregados mais dois equipamentos: um ICP OES com tocha de vista axial e sistemas Shear Gas para a eliminação da zona fria do plasma e um ICP-MS. Os resultados obtidos mostram que as presenças destes interferentes (Ca, Mg, Na) em concentrações elevadas podem causar erros na determinação de Urânio com resultados falsos positivos, em equipamentos de ICP OES que empregam o sistema de cone para eliminação da zona fria do plasma.
Molecular dynamics simulation of shock wave propagation and spall failure in single crystal copper under cylindrical impact
Authors: Chen Ying , Jian Zhiyong , Xiao Shifang , Wang Liang , Li Xiaofan , Wang Kun , Deng Huiqiu , Hu Wangyu 
Published: June 2021

Abstract
The shock premelting and spallation of single crystal copper under cylindrical converging impact are studied using molecular dynamics simulations. For the axis of a cylindrical potential wall along the [001] crystallographic direction, the anisotropy of shock response is very obvious at the shock strength 1.4 km s−1. Premelting occurs at the wavefront in the 〈110〉 direction, but not in the 〈100〉 direction. As a result of the converging effect, the requisite shock strength for generating premelting decreases in comparison with planar shock. Under the interaction of reflected wave and unloaded wave, the nucleation of spallation occurs in premelting tensile regions.
Morfogênese do capim-marandu em área degradada submetido a estratégias de manejo e adubação nitrogenada
Authors: De Melo Gilson Gomes , Gomes Marcelo Barcelo , Del Carratore Renata Rossi , Da Silva Valéria Lima , Roswalka Luciane Cristina , Tarsitano Rodrigo Anselmo 
Published: May 2021

A exploração sustentável de forrageiras requer o fornecimento adequado de nutrientes, em quantidades adequadas para o bom desenvolvimento da planta. Nesse sentido entre os nutrientes mais exigidos pelas plantas, o nitrogênio se destaca, uma vez que seu fornecimento mediante mineralização da matéria orgânica não é suficiente para suprir as necessidades da planta, em consequência alcançar maiores níveis de produtividade e qualidade das pastagens. O objetivo com este trabalho foi avaliar as características morfogênicas do capim-marandu em área degradada por meio de estratégias de manejo, utilizando como fonte nutritiva o N. O experimento foi conduzido em delineamento experimental em blocos casualisados (DBC), em um arranjo fatorial 2x4, sendo os fatores avaliados: duas alturas de pasto (25 e 35 cm) e quatro doses de nitrogênio (50,100 150 e 200 kg ha-1). Os tratamentos doses de N e altura de corte obtiveram efeitos significativos isoladamente para os parâmetros (TAlF, NFV e Filocrono). A altura de corte de 35 cm foi a que obteve maior número de folhas verdes (NFV), já a altura de 25 cm proporcionou maiores valores de Taxa de alongamento foliar. A dose de 100 kg N ha-1 proporcionou o valor máximo de Filocrono (18,75 dias/folha).
MAKNA "LETIH LESU DAN BERBEBAN BERAT" DALAM INJIL MATIUS 11:28 BERDASARKAN PRINSIP HERMENETIKA INJIL
Authors: Sibarani Yosua 
Published: May 2021

AbstractA reader of the Bible should know that ancient copies of the Old and New Testaments sometimes use different or inexact wordings regarding certain texts. This fact shows that the Bible needs to be interpreted based on the principle of correct interpretation so that today's readers understand the meaning of the text that is being read. The text of the Gospel of Matthew 11:28 is one of the many biblical texts that Christians have misunderstood as a result of the preacher's error in presenting it. This study aims to describe the concept of "tired and heavy laden" in Matthew 11:28 based on the interpretive principle that places Matthew specifically as one of the Gospels in the New Testament canon using qualitative research methods. As a result of this research, the phrase “weary and laden with weight” refers to Jews who are exhausted from carrying out the demands of the law for salvation, not to people who experience problems or problems of daily life of a physical nature. AbstrakSeorang pembaca Alkitab perlu mengetahui bahwa salinan kuno dari Perjanjian Lama dan Perjanjian Baru kadang-kadang menggunakan susunan kata yang berbeda atau tidak sama persis mengenai teks tertentu. Fakta tersebut menunjukkan bahwa Alkitab perlu ditafsirkan berdasarkan prinsip penafsiran yang benar agar pembaca masa kini memahami makna teks yang sedang dibaca. Teks Injil Matius 11:28 adalah salah satu dari sekian banyak teks Alkitab yang disalahpahami oleh orang Kristen sebagai akibat dari kekeliruan pengkhotbah menyampaikannya. Penelitian ini bertujuan untuk memaparkan konsep “letih lesu dan berbeban berat” dalam Matius 11:28 berdasarkan prinsip penafsiran yang menempatkan Matius secara khusus sebagai salah satu dari Injil dalam kanon Perjanjian Baru menggunakan metode penelitian kualitatif. Sebagai hasil dari penelitian ini, frase “letih lesu dan berbeban berat” merujuk kepada orang-orang Yahudi yang mengalami kelelahan karena melakukan tuntutan hukum Taurat untuk mendapatkan keselamatan, bukan orang-orang yang mengalami masalah atau persoalan hidup sehari-hari yang bersifat jasmani.
Real-Life Self-Control is Predicted by Parietal Activity During Preference Decision Making: A Brain Decoding Analysis
Authors: Krönke Klaus-Martin , Mohr Holger , Wolff Max , Kräplin Anja , Smolka Michael N. , Bühringer Gerhard , Ruge Hannes , Goschke Thomas 
Published: June 2021

AbstractDespite its relevance for health and education, the neurocognitive mechanism of real-life self-control is largely unknown. While recent research revealed a prominent role of the ventromedial prefrontal cortex in the computation of an integrative value signal, the contribution and relevance of other brain regions for real-life self-control remains unclear. To investigate neural correlates of decisions in line with long-term consequences and to assess the potential of brain decoding methods for the individual prediction of real-life self-control, we combined functional magnetic resonance imaging during preference decision making with ecological momentary assessment of daily self-control in a large community sample (N = 266). Decisions in line with long-term consequences were associated with increased activity in bilateral angular gyrus and precuneus, regions involved in different forms of perspective taking, such as imagining one’s own future and the perspective of others. Applying multivariate pattern analysis to the same clusters revealed that individual patterns of activity predicted the probability of real-life self-control. Brain activations are discussed in relation to episodic future thinking and mentalizing as potential mechanisms mediating real-life self-control.
Pemanfaatan Google Sites Untuk Penerimaan Peserta Didik Baru Bagi Madrasah Se-Riau
Authors: Firdaus Rahmad , Unik Mitra , Wenando Febby Apri , Fitri Diah Angraina 
Published: May 2021

Kegiatan Pengabdian Masyarakat (PKM) ini dilaksanakan sebagai bentuk upaya untuk membantu pihak sekolah khususnya Madrasah di Provinsi Riau dalam membantu proses Penerimaan Peserta Didik baru (PPDB) yang dilakukan secara online selama masa pandemi COVID-19 berlangsung. Kegiatan dilaksanakan secara daring menggunakan platform aplikasi Zoom dalam bentuk seminar yang dimulai dengan pemaparan materi tentang pengenalan Google Sites, penggunaan dan pemanfaatan fitur yang ada pada Google Sites dan bagaimana memanfaatkan Google Sites tersebut sehingga bisa dipakai untuk Penerimaan Peserta Didik Baru (PPDB). Pemaparan materi dilakukan diikuti dengan praktek langsung dengan peserta tentang penggunaan fitur yang ada pada Google Sites yang bisa dimanfaatkan untuk pelaksanaan PPDB.

Kata Kunci: PPDB, Google Sites, PKM, Zoom, COVID-19
Pelatihan Penulisan Soal Comprehension Questions Para Tutor Berbasis HOTS Bahasa Inggris
Authors: Hadi Irvan , Liskasaputri Nia 
Published: May 2021

Abstrak
Penulisan berbasis HOTS masih menjadi kendala bagi para tutor. Hal ini disebkan oleh kurangnya sosialisasi untuk para tutor pada lembaga bahasa Inggris. Mereka perlu dibekai sehingga dapat empraktekkan soal-soal berbasis HOTS. Metode pelaksanaan yang digunkan adalah observasi, wawancara dan diskusi serta perencanaa pembuat luaran dari hasil pelaksanaan ini. Kegiatan ini diikuti oleh para tutor yang berjumlah 10 orang pada bulan awal Maret 2020 sampai dengan Mei 2020. Hasil pelaksanaan sangat bermanfaat karena dapat menambah pengetahuan dan wawasan bagi para guru yang secara tidak langsung dapat meningkatkan mutu pendidikan, oleh karenanya mereka berpendapat kalau kegiatan seperti ini sangat penting untuk dilakukan. Sebagian lainnya menyatakan bahwa pelaksanaan kegiatan pelatihan ini berjalan dengan baik dengan metode penyampaian yang mudah dipahami dan menyenangkan.Saran dari terlaksannya kegiatan ini agar terdapat adanya tindak lanjut dari kegiatan serupa dengan alokasi waktu yang lebih banyak, materi yang lebih bervariasi dan juga peserta yang lebih banyak.
Kata Kunci : Pelatihan, soal , HOTS