bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal seizures as onset of Inborn Errors of Metabolism (IEMs): from diagnosis to treatment. A systematic review
Authors: Falsaperla Raffaele , Sciuto Laura , La Spina Luisa , Sciuto Sarah , Praticò Andrea D. , Ruggieri Martino 
Published: August 2021

AbstractNeonatal seizures (NS) occur in the first 28 days of life; they represent an important emergency that requires a rapid diagnostic work-up to start a prompt therapy. The most common causes of NS include: intraventricular haemorrhage, hypoxic-ischemic encephalopathy, hypoglycemia, electrolyte imbalance, neonatal stroke or central nervous system infection. Nevertheless, an Inborn Error of Metabolism (IEM) should be suspected in case of NS especially if these are resistant to common antiseizure drugs (ASDs) and with metabolic decompensation. Nowadays, Expanded Newborn Screening (ENS) has changed the natural history of some IEMs allowing a rapid diagnosis and a prompt onset of specific therapy; nevertheless, not all IEMs are detected by such screening (e.g. Molybdenum-Cofactor Deficiency, Hypophosphatasia, GLUT1-Deficiency Syndrome) and for this reason neonatologists have to screen for these diseases in the diagnostic work-up of NS. For IEMs, there are not specific semiology of seizures and EEG patterns. Herein, we report a systematic review on those IEMs that lead to NS and epilepsy in the neonatal period, studying only those IEMs not included in the ENS with tandem mass, suggesting clinical, biochemical features, and diagnostic work-up. Remarkably, we have observed a worse neurological outcome in infants undergoing only a treatment with common AED for their seizures, in comparison to those primarily treated with specific anti-convulsant treatment for the underlying metabolic disease (e.g.Ketogenic Diet, B6 vitamin). For this reason, we underline the importance of an early diagnosis in order to promptly intervene with a targeted treatment without waiting for drug resistance to arise.
Complete genome analysis of African swine fever virus responsible for outbreaks in domestic pigs in 2018 in Burundi and 2019 in Malawi
Authors: Hakizimana Jean N. , Ntirandekura Jean B. , Yona Clara , Nyabongo Lionel , Kamwendo Gladson , Chulu Julius L. C. , Ntakirutimana Désiré , Kamana Olivier , Nauwynck Hans , Misinzo Gerald 
Published: August 2021

AbstractSeveral African swine fever (ASF) outbreaks in domestic pigs have been reported in Burundi and Malawi and whole-genome sequences of circulating outbreak viruses in these countries are limited. In the present study, complete genome sequences of ASF viruses (ASFV) that caused the 2018 outbreak in Burundi (BUR/18/Rutana) and the 2019 outbreak in Malawi (MAL/19/Karonga) were produced using Illumina next-generation sequencing (NGS) platform and compared with other previously described ASFV complete genomes. The complete nucleotide sequences of BUR/18/Rutana and MAL/19/Karonga were 176,564 and 183,325 base pairs long with GC content of 38.62 and 38.48%, respectively. The MAL/19/Karonga virus had a total of 186 open reading frames (ORFs) while the BUR/18/Rutana strain had 151 ORFs. After comparative genomic analysis, the MAL/19/Karonga virus showed greater than 99% nucleotide identity with other complete nucleotides sequences of p72 genotype II viruses previously described in Tanzania, Europe and Asia including the Georgia 2007/1 isolate. The Burundian ASFV BUR/18/Rutana exhibited 98.95 to 99.34% nucleotide identity with genotype X ASFV previously described in Kenya and in Democratic Republic of the Congo (DRC). The serotyping results classified the BUR/18/Rutana and MAL/19/Karonga ASFV strains in serogroups 7 and 8, respectively. The results of this study provide insight into the genetic structure and antigenic diversity of ASFV strains circulating in Burundi and Malawi. This is important in order to understand the transmission dynamics and genetic evolution of ASFV in eastern Africa, with an ultimate goal of designing an efficient risk management strategy against ASF transboundary spread.
You Shall (Not) Pass: Strategies for Third-Party Gatekeepers to Enhance Volunteer Inclusion
Authors: van Overbeeke Philine S. M. , Koolen-Maas Stephanie A. , Meijs Lucas C. P. M. , Brudney Jeffrey L. 
Published: August 2021

AbstractVolunteering appears to be a mechanism that can contribute to societal inclusion. As nonprofit organizations continuously seek more volunteers, opportunities for volunteer inclusion seem limitless. We argue that, in reality, it is not that simple. Volunteer exclusion derives from the failure to seek, recruit, and place potential volunteers with antecedents predicting non-volunteering. This article focuses on the “sending-organization” in dual volunteer management. We look at sending-organizations, such as a corporation or school, that organizes volunteer opportunities for its participants in a “receiving-organization,” i.e., the organization where the volunteer service is performed. Based on qualitative data generated from semi-structured and vignette interviews, we explore the crucial role that gatekeepers at the sending-organization play in the inclusion and exclusion of volunteers in receiving-organizations. We identify three strategies for these sending-gatekeepers to enhance volunteer inclusion: encouraging, enabling, and enforcing.
A class of weighted Hardy type inequalities in $$\mathbb {R}^N$$
Authors: Canale Anna 
Published: August 2021

AbstractIn the paper we prove the weighted Hardy type inequality $$\begin{aligned} \int _{{{\mathbb {R}}}^N}V\varphi ^2 \mu (x)dx\le \int _{\mathbb {R}^N}|\nabla \varphi |^2\mu (x)dx +K\int _{\mathbb {R}^N}\varphi ^2\mu (x)dx, \end{aligned}$$

∫

R

N

V

φ
2

μ

(
x
)

d
x
≤

∫

R

N

|
∇
φ
|

2

μ

(
x
)

d
x
+
K

∫

R

N

φ
2

μ

(
x
)

d
x
,

for functions $$\varphi $$
φ
in a weighted Sobolev space $$H^1_\mu $$

H
μ
1

, for a wider class of potentials V than inverse square potentials and for weight functions $$\mu $$
μ
of a quite general type. The case $$\mu =1$$

μ
=
1

is included. To get the result we introduce a generalized vector field method. The estimates apply to evolution problems with Kolmogorov operators $$\begin{aligned} Lu=\varDelta u+\frac{\nabla \mu }{\mu }\cdot \nabla u \end{aligned}$$

L
u
=
Δ
u
+

∇
μ

μ

·
∇
u

perturbed by singular potentials.
Importance of Social Determinants in Screening for Depression
Authors: Califf Robert M. , Wong Celeste , Doraiswamy P. Murali , Hong David S. , Miller David P. , Mega Jessica L. ,   for the Baseline Study Group
Published: August 2021

Abstract

Importance
The most common screening tool for depression is the Patient Health Questionnaire-9 (PHQ-9). Despite extensive research on the clinical and behavioral implications of the PHQ-9, data are limited on the relationship between PHQ-9 scores and social determinants of health and disease.

Objective
To assess the relationship between the PHQ-9 at intake and other measurements intended to assess social determinants of health.

Design, Setting, and Participants
Cross-sectional analyses of 2502 participants from the Baseline Health Study (BHS), a prospective cohort of adults selected to represent major demographic groups in the US; participants underwent deep phenotyping on demographic, socioeconomic, clinical, laboratory, functional, and imaging findings.

Interventions
None.

Main Outcomes and Measures
Cross-sectional measures of clinical and socioeconomic status (SES).

Results
In addition to a host of clinical and biological factors, higher PHQ-9 scores were associated with female sex, younger participants, people of color, and Hispanic ethnicity. Multiple measures of low SES, including less education, being unmarried, not currently working, and lack of insurance, were also associated with higher PHQ-9 scores across the entire spectrum of PHQ-9 scores. A summative score of SES, which was the 6th most predictive factor, was associated with higher PHQ-9 score after adjusting for 150 clinical, lab testing, and symptomatic characteristics.

Conclusions and Relevance
Our findings underscore that depression should be considered a comorbidity when social determinants of health are addressed, and both elements should be considered when designing appropriate interventions.
Values, science, and competing paradigms in sustainability research: furthering the conversation
Authors: Boda Chad S. 
Published: August 2021

AbstractSustainability science is fundamentally a problem-driven and solutions-oriented science which necessitates engagement with questions of interdisciplinarity and normativity. Nagatsu et al. (2020) recently investigated the significance of these peculiar characteristics and produce a useful and timely overview of the problems facing sustainability science, as a science. Perhaps the most crucial and crosscutting challenge they identify regards the need for researchers to justify the particular values guiding sustainability research. In the spirit of advancing Nagatsu et al.’s agenda for further developing the role of values in sustainability science, I argue two things. First, that there are in practice several active and competing approaches to dealing with the problem of normativity in sustainablity science that provide options to researchers. Second, that this unresolved tension at the core of sustainability science points to a more overarching problem, namely the need to more explicitly identify coherent, competing research paradigms within the field.
Exploring the experience of Gamblers Anonymous meetings during COVID-19: a qualitative study
Authors: Penfold Katy L. , Ogden Jane 
Published: August 2021

AbstractWhilst much research has explored the possible causes and consequences of gambling, Gamblers Anonymous (GA) − one of the most accessed forms of support for gamblers - has been largely overlooked and, to date, only a few studies have explored how members experience this programme. Core to GA is the social interaction between members. From March 2020, however, the COVID-19 pandemic forced GA to move their meetings online. The present qualitative study therefore explored how GA members experienced these online meetings in the absence of actual face to face interactions with others. Individual telephone or video call interviews (n = 21) were carried out with members of GA in the UK and analysed using Thematic Analysis. The results described three main themes: (1) ‘practicalities of GA in lockdown’, which highlighted the practical benefits of online meetings such as more opportunity to attend different meetings, which in turn expanded participants’ perspectives and social networks; (2) ‘the importance of relationships in GA’, reflecting strong and enduring social networks that were created, maintained, and strengthened by feelings of solidarity; and (3) ‘therapeutic elements of the meetings’, such as psychological contract making which helped participants to stay abstinent. Transcending these themes was a tension between individual versus group identity with interviewees reporting a shift to focusing more on their own needs rather than those of the group. Overall, whilst still providing a lifeline during COVID-19 and offering some practical benefits, the online GA meetings were not able to completely replicate the value individuals gained from face to face meetings. This transition also resulted in disruptions both to group dynamics and to individual interactions within each group, ultimately resulting in participants behaving more individualistically and less collectively than in face-to-face meetings.
Unresectable pleural mesothelioma—hope or still an unmet medical need?
Authors: Absenger Gudrun , Terbuch Angelika 
Published: August 2021

SummaryMalignant pleural mesothelioma (MPM) is a rare tumour that originates from the inner linings of the pleural cavity. The majority of cases are associated with exposure to asbestos for what was banned in the European Union in 1991. Due to the long latency between exposure and onset (20–40 years) the peak of MPM in Western Europe will be reached within the next years. Often diagnosed at an unresectable stage, treatment options remain palliative in the majority of cases. The highly aggressive nature of MPM leads to a dismal prognosis with a median overall survival of approximately one year.Platinum-based chemotherapy in combination with pemetrexed has been the mainstay of first line treatment in unresectable MPM for many years. Only recently, check point inhibitors have found their way into MPM treatment. The results of the phase III CheckMate 743 trial last year have finally led to a paradigm shift in the treatment of unresectable MPM. This trial showed a significant overall survival benefit for the combination of nivolumab and ipilimumab over standard chemotherapy, especially in nonepithelioid histology. Apart from histology, predictive biomarkers have not been identified for the treatment of MPM so far. Several trials investigating combination therapies with checkpoint inhibitors are currently ongoing and give hope to further improve prognosis for our patients.
High chromosome instability identified by low-pass whole-genome sequencing assay is associated with TP53 copy loss and worse prognosis in BRCA1 germline mutation breast cancer
Authors: Zhu Liang , Pan Jia-Ni , Qian Ziliang , Ye Wei-Wu , Wang Xiao-Jia , Cao Wen-Ming 
Published: August 2021

Abstract
Background
Though BRCA1 mutation is the most susceptible factor of breast cancer, its prognostic value is disputable. Here in this study, we use a novel method which based on whole-genome analysis to evaluate the chromosome instability (CIN) value and identified the potential relationship between CIN and prognosis of breast cancer patients with germline-BRCA1 mutation.

Materials and methods
Sanger sequencing or a 98-gene panel sequencing assay was used to screen for BRCA1 germline small mutations in 1151 breast cancer patients with high-risk factors. MLPA assay was employed to screen BRCA1 large genomic rearrangements in familial breast cancer patients with BRCA1 negative for small mutations. Thirty-two samples with unique BRCA1 germline mutation patterns were further subjected to CIN evaluation by LPWGS (low-pass whole-genome sequencing) technology.

Results
Firstly, 113 patients with germline BRCA1 mutations were screened from the cohort. Further CIN analysis by the LPWGS assay indicated that CIN was independent from the mutation location or type of BRCA1. Patients with high CIN status had shorter disease-free survival rates (DFS) (HR = 6.54, 95% CI 1.30–32.98, P = 0.034). The TP53 copy loss was also characterized by LPWGS assay. The rates of TP53 copy loss in CIN high and CIN low groups were 85.71% (12/14) and 16.67% (3/18), respectively.

Conclusion
CIN-high is a prognostic factor correlated with shorter DFS and was independent with the germline BRCA1 mutation pattern. Higher CIN values were significantly correlated with TP53 copy loss in breast cancer patients with germline BRCA1 mutation. Our results revealed a reliable molecular parameter for distinguishing patients with poor prognosis from the BRCA1-mutated breast cancer patients.
Construction and use of rock-cut cisterns: a chronological OSL approach in the arid Negev Highlands, Israel
Authors: Junge Andrea , Dunseth Zachary C. , Shahack-Gross Ruth , Finkelstein Israel , Fuchs Markus 
Published: August 2021

AbstractThe Negev Highlands (Israel) are characterized by a rich settlement history over the last millennia. To sustain life in this arid environment, measures to collect and store water were introduced. Two types of installations to collect and store runoff water were built in the region: open reservoirs, and more elaborate subterranean rock-cut cisterns. This article focuses on the latter. Based on a few inscriptions found in rock-cut cisterns, it is assumed that the majority were constructed in the Hellenistic (Nabatean) to Byzantine period. To evaluate this age assessment, this study was carried out at the Borot Hazaz cisterns system, using optically stimulated luminescence (OSL) dating together with micromorphological analyses. Both were applied to sediments that were relocated during the cistern’s construction and usage and after the maintenance activities ended. Despite unfavourable conditions for resetting the OSL signal, including fluvial transport over short distances and sediment deposition by humans in large quantities, it was possible to reconstruct the life cycle of the cistern system. The present study places the construction of the system during the late Roman to Byzantine period, with utilization and long-term maintenance during the following centuries. Maintenance ceased at the Borot Hazaz cistern system gradually over the course of the last 500 years.
Towards higher aerodynamic efficiency of propeller-driven aircraft with distributed propulsion
Authors: Keller Dennis 
Published: August 2021

AbstractThe scope of the present paper is to assess the potential of distributed propulsion for a regional aircraft regarding aero-propulsive efficiency. Several sensitivities such as the effect of wingtip propellers, thrust distribution, and shape modifications are investigated based on a configuration with 12 propulsors. Furthermore, an initial assessment of the high-lift performance is undertaken in order to estimate potential wing sizing effects. The performance of the main wing and the propellers are thereby equally considered with the required power being the overall performance indicator. The results indicate that distributed propulsion is not necessarily beneficial regarding the aero-propulsive efficiency in cruise flight. However, the use of wing tip propellers, optimization of the thrust distribution, and wing resizing effects lead to a reduction in required propulsive power by $$-2.9$$

-
2.9

to $$-3.3\,\%$$

-
3.3

%

compared to a configuration with two propulsors. Adapting the leading edge to the local flow conditions did not show any substantial improvement in cruise configuration to date.
A Systematic Review of Play-Based Interventions Targeting the Social Communication Skills of Children with Autism Spectrum Disorder in Educational Contexts
Authors: O’Keeffe Christina , McNally Sinéad 
Published: August 2021

AbstractChildren with autism spectrum disorder (ASD) experience social communication difficulties which can be compounded by increased social demands and expectations of the school environment. Play offers a unique context for social communication development in educational settings. This systematic review aimed to synthesize play-based interventions for the social communication skills of children with ASD in educational contexts and identified nine studies. Overall, studies in this review provided a promising evidence base for supporting social communication skills through play in education for children with ASD. The review also highlighted gaps in research on play-based interventions for the social communication skills of children with ASD within naturalistic educational settings.
Image Preprocessing in Classification and Identification of Diabetic Eye Diseases
Authors: Sarki Rubina , Ahmed Khandakar , Wang Hua , Zhang Yanchun , Ma Jiangang , Wang Kate 
Published: August 2021

AbstractDiabetic eye disease (DED) is a cluster of eye problem that affects diabetic patients. Identifying DED is a crucial activity in retinal fundus images because early diagnosis and treatment can eventually minimize the risk of visual impairment. The retinal fundus image plays a significant role in early DED classification and identification. An accurate diagnostic model’s development using a retinal fundus image depends highly on image quality and quantity. This paper presents a methodical study on the significance of image processing for DED classification. The proposed automated classification framework for DED was achieved in several steps: image quality enhancement, image segmentation (region of interest), image augmentation (geometric transformation), and classification. The optimal results were obtained using traditional image processing methods with a new build convolution neural network (CNN) architecture. The new built CNN combined with the traditional image processing approach presented the best performance with accuracy for DED classification problems. The results of the experiments conducted showed adequate accuracy, specificity, and sensitivity.
Fine-Grained Multi-label Sexism Classification Using a Semi-Supervised Multi-level Neural Approach
Authors: Abburi Harika , Parikh Pulkit , Chhaya Niyati , Varma Vasudeva 
Published: August 2021

AbstractSexism, a permeate form of oppression, causes profound suffering through various manifestations. Given the increasing number of experiences of sexism shared online, categorizing these recollections automatically can support the battle against sexism, since it can promote successful evaluations by gender studies researchers and government representatives engaged in policy making. In this paper, we examine the fine-grained, multi-label classification of accounts (reports) of sexism. To the best of our knowledge, we consider substantially more categories of sexism than any related prior work through our 23-class problem formulation. Moreover, we present the first semi-supervised work for the multi-label classification of accounts describing any type(s) of sexism. We devise self-training-based techniques tailor-made for the multi-label nature of the problem to utilize unlabeled samples for augmenting the labeled set. We identify high textual diversity with respect to the existing labeled set as a desirable quality for candidate unlabeled instances and develop methods for incorporating it into our approach. We also explore ways of infusing class imbalance alleviation for multi-label classification into our semi-supervised learning, independently and in conjunction with the method involving diversity. In addition to data augmentation methods, we develop a neural model which combines biLSTM and attention with a domain-adapted BERT model in an end-to-end trainable manner. Further, we formulate a multi-level training approach in which models are sequentially trained using categories of sexism of different levels of granularity. Moreover, we devise a loss function that exploits any label confidence scores associated with the data. Several proposed methods outperform various baselines on a recently released dataset for multi-label sexism categorization across several standard metrics.