bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pneumomediastinum, pneumopericardium, and subcutaneous emphysema—a rare complication in COVID-19 infection
Authors: Baburao Archana , Das Rinki , Shyamsunder Shylaja 
Published: July 2021

Abstract
Background
Coronavirus disease 2019 (COVID-19) has become a global pandemic and is posing a serious public health problem for almost all countries. Spontaneous pneumomediastinum, a rare condition, is usually seen in patients with underlying pulmonary pathology, infections, or mechanical ventilation. Spontaneous pneumomediastinum is a rare complication in COVID-19 pneumonia.

Case presentation
We report a case of spontaneous pneumomediastinum, pneumopericardium, and subcutaneous emphysema in a 62-year-old diabetic patient with COVID-19 infection who presented with cough, fever, and breathlessness, which turned to be a fatal complication.

Conclusion
Pneumomediastinum/subcutaneous emphysema, a not so common complication associated with COVID-19 infection, should be considered as a bad prognostic indicator of worsening disease and hence requires early recognition and careful monitoring of the patient for any possible unfavorable outcome.
Endocrine Treatment and Targeted Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer: ASCO Guideline Update
Authors: Burstein Harold J. , Somerfield Mark R. , Barton Debra L. , Dorris Ali , Fallowfield Lesley J. , Jain Dharamvir , Johnston Stephen R. D. , Korde Larissa A. , Litton Jennifer K. , Macrae Erin R. , Peterson Lindsay L. , Vikas Praveen , Yung Rachel L. , Rugo Hope S. 
Published: July 2021

PURPOSE To update recommendations of the ASCO systemic therapy for hormone receptor (HR)-positive metastatic breast cancer (MBC) guideline. METHODS An Expert Panel conducted a systematic review to identify new, potentially practice-changing data. RESULTS Fifty-one articles met eligibility criteria and form the evidentiary basis for the recommendations. RECOMMENDATIONS Alpelisib in combination with endocrine therapy (ET) should be offered to postmenopausal patients, and to male patients, with HR-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, ABC, or MBC following prior endocrine therapy with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor. Clinicians should use next-generation sequencing in tumor tissue or cell-free DNA in plasma to detect PIK3CA mutations. If no mutation is found in cell-free DNA, testing in tumor tissue, if available, should be used as this will detect a small number of additional patients with PIK3CA mutations. There are insufficient data at present to recommend routine testing for ESR1 mutations to guide therapy for HR-positive, HER2-negative MBC. For BRCA1 or BRCA2 mutation carriers with metastatic HER2-negative breast cancer, olaparib or talazoparib should be offered in the 1st-line through 3rd-line setting. A nonsteroidal aromatase inhibitor (AI) and a CDK4/6 inhibitor should be offered to postmenopausal women with treatment-naïve HR-positive MBC. Fulvestrant and a CDK4/6 inhibitor should be offered to patients with progressive disease during treatment with AIs (or who develop a recurrence within 1 year of adjuvant AI therapy) with or without one line of prior chemotherapy for metastatic disease, or as first-line therapy. Treatment should be limited to those without prior exposure to CDK4/6 inhibitors in the metastatic setting. Additional information can be found at www.asco.org/breast-cancer-guidelines .
Longitudinal Experience With and Impressions of COVID-19–Related Clinical Research Changes
Authors: Gerber David E. , Clark Valerie L. , Sheffield Thomas Y. , Beg M. Shaalan , Xie Yang , Holbein M. E. Blair , Skinner Celette Sugg , Lee Simon J. Craddock , Williams Erin L. 
Published: July 2021

PURPOSE:The COVID-19 pandemic has led to profound changes in clinical research, including remote consent, telehealth, off-site procedures, shipment of therapy, and remote study monitoring. We assessed longitudinal perceptions of these adjustments among clinical research professionals.METHODS:We distributed an anonymous survey assessing experiences, perceptions, and recommendations regarding COVID-19–related clinical research adjustments to cancer clinical research office personnel in May 2020 and again in November 2020. Responses were compared using Fisher's exact and Mann-Whitney U tests.RESULTS:A total of 90 of 102 invited research personnel (88%) responded. Fifty-three (59%) reported participating in both initial and follow-up surveys. The proportion of respondents reporting personal experience with COVID-19–related adjustments increased over time, particularly for remote initial consent (29% v 4%), remote reconsent (24% v 9%), and remote study monitoring (36% v 22%). Perceived impact of COVID-19–related adjustments on data quality ( P = .02) and patient experience ( P = .002) improved significantly. However, perceived effect on patient safety ( P = .02) and respondent's experience ( P = .09) became less favorable. Individuals with personal experience with the adjustment were more likely to recommend continuing remote consent (62% v 38%; P = .04), remote monitoring (69% v 45%; P = .05), and therapy shipment (67% v 35%; P = .01) after the COVID-19 pandemic, with nonsignificant trends for off-site diagnostics (44% v 24%; P = .13) and telehealth visits (66% v 45%; P = .08).CONCLUSION:More than 6 months into the global pandemic, perceptions of COVID-19–related clinical research changes remain favorable. Experienced individuals are more likely to recommend that these changes continue in the future.
Faithful entanglement distribution using quantum multiplexing in noisy channel
Authors: Zhao Peng , Zhou Lan , Zhong Wei , Sheng Yu-Bo 
Published: July 2021

Abstract
Quantum multiplexing provides us with a powerful approach that can distribute entanglement using only a single photonic pulse to interact with remote quantum memories. In common entanglement distribution protocols, the entanglement purification is often exploited if the distributed entanglement is degraded by the channel noise. In this protocol, we propose a faithful entanglement distribution protocol using quantum multiplexing of photon in a collective noise channel. By designing the encoding and decoding setup, our protocol can resist the collective noise. When the protocol is successful, the parties can obtain two pairs of maximally entangled states. When the protocol fails, the parties can still obtain one pair of maximally entangled state. Our protocol does not require the entanglement purification, so that it is more efficient. The above advantages enable our protocol to have important application potential in the future quantum communication field.
Mechanical and chemical activation of GPR68 probed with a genetically encoded fluorescent reporter
Authors: Ozkan Alper D. , Gettas Tina , Sogata Audrey , Phaychanpheng Wynn , Zhou Miou , Lacroix Jérôme J. 
Published: July 2021

ABSTRACT
G-protein-coupled receptor (GPCR) 68 (GPR68, or OGR1) couples extracellular acidifications and mechanical stimuli to G-protein signaling and plays important roles in vascular physiology, neuroplasticity and cancer progression. Inspired by previous GPCR-based reporters, here, we inserted a cyclic permuted fluorescent protein into the third intracellular loop of GPR68 to create a genetically encoded fluorescent reporter of GPR68 activation we call ‘iGlow’. iGlow responds to known physiological GPR68 activators such as fluid shear stress and extracellular acidifications. In addition, iGlow responds to Ogerin, a synthetic GPR68-selective agonist, but not to a non-active Ogerin analog, showing the specificity of iGlow-mediated fluorescence signals. Flow-induced iGlow activation is not eliminated by pharmacological modulation of downstream G-protein signaling, disruption of actin filaments or application of GsMTx4, an inhibitor of certain mechanosensitive ion channels activated by membrane stretch. Deletion of the conserved helix 8, proposed to mediate mechanosensitivity in certain GPCRs, does not eliminate flow-induced iGlow activation. iGlow could be useful to investigate the contribution of GPR68-dependent signaling in health and disease.
Media literacy in video production: An experiment with university students
Authors: Kaperonis Stavros 
Published: July 2021

This article describes an experimental academic e-course during the Covid-19 pandemic, in which 178 undergraduate students were asked to become video creators and narrators through a specific methodology in order to become digitally literate and produce original content.This practical e-workshop took place in the context of the “Video, Image and Audio Editing” course of the Department of Communication, Media and Culture at Panteion University and was adapted to the needs of a distance learning course. Its main aim was the students’ familiarization with literacy in digital tools and techniques that until now was only achieved in an actual laboratory setting. The research is divided into two phases. The first phase concerns this article and analyzes the methodology of video production as well as the students’ acquisition of digital tools. In the second phase, specific factors will be studied, from the videos produced, through qualitative research so as to determine the audience’s interaction with the narrative content, as well as with the factors that students believe contributed to the interaction of that content.Students gained knowledge of digital video tools which was upgraded to the capabilities and needs of each student. They acquired video editing skills based on the content through a specific theme and a theme of each group student’s choice. Students increased their literacy skills in both digital media and video projection on social media and gained knowledge concerning the interaction that was encouraged through these mediums. In this laboratory course, a specific methodology was used that included pre-production, production and post-production. The final product included two videos, the first with a specific theme and the second with a theme of each group student’s choice.
„Łemko nosi ból w genach”
Authors: Hajduk-Nijakowska Janina 
Published: July 2021

“A Lemko carries his pain in his genes.” The Face of the Lemkos’ Post-Memory
The material being presented in this paper is a study case – the analysis of an interview which the author conducted with a granddaughter of the Lemkos displaced to Lower Silesia in 1947 as part of Operation Vistula. The narration of the interlocutor overfilled with emotions reveals the traumatic context of her incessant search for an answer to the question: Who am I? Since she did not agree to make the entirety of her talk public, transferring in this way the obligation to protect her name onto the author, the interview became a unique personal experience for the latter at the same time. Therefore, only those fragments of the above-mentioned interview are referred to in the text, which can be juxtaposed against opinions and sentiments of other Lemkos of the third generation. The aim is to make precise the contemporary picture of the Lemkos’ family-based post-memory that is burdened with the sense of harm and humiliation.
Od znikania do odpominania
Authors: Wieżgowiec Barbara 
Published: July 2021

From Disappearance to Re-Remembrance. Post-Memory Narration about Miedzianka
Miedzianka – a lower Silesian village, earlier: mining town and a leisure-tourist resort, ger. Kupferberg. It is said that it is a ghost-town, which has (almost) diaappeared. Some traces, however, remained – a church, photography or human memories – both from before World War II, of German citizens and after the world war of polish inhabitants. All of them are connected by the traumatic experience that combines post-war resettlement and the destruction of the town. The memory of Miedzianka was not destroyed, though, being passed to next generations. One of the voices of this post-memory can be found in the report by Filip Springer, Miedzianka: Story of Disappearing in 2011. This book quickly became recognised ensuing an increasing interest in the town, its history and fate, making new post-memory narrations to appear, which I describe as „post-memory practice”. One of them is Miasto, którego nie było (The City, which didn’t exist). What and how do these books tell us about Miedzianka? In what sense do these alternative but interpenetrating narrations influence the perception of this place, as well as the memory of it? These questions are the basis of the reflections leading to a display of relations between man and his oblivion/memory and the place. The literature, however, or widely art, having the power to preserve memory and therefore to save, allows the showcasing of the transformation of the town: its history, disappearance, and finally transubstantiation into a place of memory, which is created mainly by the second and third generations – heritage depositories.
Historia mojego ojca: zaraz wam odegram… Czyli jak pamięta drugie pokolenie?
Authors: Papier Sylwia 
Published: July 2021

My Father’s Story: I’ll Play You Right Away… So How Do the Second Generation Remember?
The aim of the article is to discuss the life story of the survivor, Majer Jesion and the joint work of daughter and father on discovering memory and the past, as well as to analyze the result of this work: the spectacle 121 023 J (dir. Ariel Goldmann, Sao Paulo), including the construction of the history and stage spaces with the usage of props to visualize the difficult past. In 2002, Renata Jesion decided to put on stage the traumatic story of her father in which she embodied him on stage. The theater medium serves her in the intergenerational transmission of the memory of the Holocaust. This monodrama will be analyzed in the light of the theory of post-memory (M. Hirsch), testifying through the medium of the theater (G. Niziołek, F. Rokem), and Self-Revelatory Performance (R. Emunah, A. Volkas).
Vigilância sanitária: revisão integrativa dos processos de capacitação da força de trabalho
Authors: Lopes Marcela Bella , Cordeiro Benedito Carlos 
Published: July 2021

Resumo: Evidências de estudo de Vigilância Sanitária (Visa) têm demonstrado a falta de financiamento para executar as ações de Visa, consequentemente, com poucas atividades de capacitação na área, além da não implementação da política de educação permanente. Esta pesquisa objetivou avaliar as publicações na área quanto as capacitações de recursos humanos e a implantação da educação permanente como estratégia de ensino. Assim, foi realizada uma revisão integrativa por meio de uma busca nas bases de dados Medline e Lilacs no período de fevereiro a março de 2020. O levantamento bibliográfico alcançou uma busca de 516 artigos como amostra inicial, sendo que, após o uso de filtros, permaneceram 38 artigos. Somente 21 foram lidos integralmente, dentre os quais 7 atenderam os critérios de inclusão e exclusão. Identificou-se que existe uma deficiência na política de educação permanente em vigilância sanitária, ausência de projeto político pedagógico, incluindo a temática de Visa nos cursos de ensino superior, falta de investimento e valorização quanto a necessidade de capacitação para os profissionais e, por fim, existe a necessidade de implantar novas formas de aprendizado para os trabalhadores da área. Por ser muito abrangente, esse campo de trabalho exige que os profissionais tenham saberes de diversos campos de atuação para maior efetividade e resolutividade. Faz-se necessária uma intensificação em estratégias educacionais, pois a ausência de uma ampla política de capacitação desses trabalhadores pode causar impactos na proteção da saúde das coletividades.
Does the vascular development of the femoral head correlate with the incidence of avascular necrosis of the proximal femoral epiphysis in children with developmental dysplasia of the hip treated by closed reduction?
Authors: Wu JianPing , Yuan Zhe , Li JingChun , Zhu MingWei , Canavese Federico , Fuxing Xun , Li YiQiang , Xu HongWen 
Published: July 2021

Purpose The purpose of this study was to identify the correlation between the vascular development of the femoral head and avascular necrosis (AVN) in patients with developmental dysplasia of the hip (DDH) treated by closed reduction (CR). Methods We retrospectively reviewed 78 patients with DDH treated by CR (83 hips). The vascular maturity, number of vessels and perfusion changes of the femoral head were assessed on perfusion MRI (pMRI) before and after CR. Results The number of vessels (mean 4.2 sd 1.4) of the femoral head and the ratio (36.1%) of mature vessels (type III) on the dislocated side were significantly less than those at contralateral side (mean 6.0 sd 1.2; 82.2%) (p < 0.001). Of the included 83 hips, 39 hips (61.5%) showed decreased perfusion of the femoral head, including partial decreased (Class B, 47.0%) and global decreased (Class C, 14.5%), at the dislocated side, which was significantly more than those at contralateral side (0.0%) (p < 0.001). In total, 32 out of 83 hips (38.5%) developed AVN. The rate of AVN with Class A (18.8%) which perfusion of the femoral head was normal (unchanged or enhanced) was significantly less than those with Class C (66.7%) (p = 0.006). Conclusion The vascular development and perfusion changes of the femoral head on the dislocated side are significantly worse than those at contralateral side. Immature vascularity of the femoral head before CR and poor perfusion of the femoral head after CR may be risk factors for AVN in patients with DDH. Level of evidence III
Comprehensive numerical evaluation of amplified spontaneous emission in a multislab Nd:glass laser amplifier
Authors: Wang Xiaoqin , Li Xuechun , Wang Jiangfeng , Guo Jiangtao , Lu Xinghua , Xiao Qi , Fan Wei 
Published: July 2021

A systematic design of a 100 J/10 Hz multislab Nd:glass laser amplifier is proposed. A four-dimensional numerical model was developed for exploring the influence of amplified spontaneous emission (ASE) on the stored energy of the laser amplifier. The influences of different parameters, including the doping concentration of the gain slab, pump pulse duration (

T

p
u
m
p

), and pump energy density (

E
p

) absorbed in the gain slab, on the stored energy and storage efficiency were studied in detail. Furthermore, the uniform distribution of the stored energy for a larger aperture of the gain slab and a higher pump energy density of the laser amplifier was determined. In addition, the effects of the slab-to-slab transfer of ASE rays on the stored energy were explored. The results show that the distributions of the stored energy for the 100 J/10 Hz laser amplifier were uniform; furthermore, an average storage efficiency of 60.87% was obtained when the pump energy density absorbed in each slab was

0.9

J

/

c

m

3

and the pump duration was 300 µs.
Prediction of hearing outcomes in chronic otitis media patients underwent tympanoplasty using ossiculoplasty outcome parameter staging or middle ear risk indices
Authors: Jung Da Jung , Lee Hyun Ju , Hong Ji Song , Kim Dong Gyu , Mun Jae Yeon , Bae Jong-Won , Yoo Myung Hoon , Lee Kyu-Yup 
Published: July 2021

Purpose
Ossiculoplasty outcome parameter staging (OOPS) and middle ear risk index (MERI) are the most commonly used indices for predicting prognosis of patients with chronic otitis media (COM). This study aimed to verify the efficiency of OOPS and MERI scores in predicting outcomes of patients with COM who underwent tympanoplasty.

Methods
We retrospectively reviewed the data of patients who underwent tympanoplasty (n = 526). OOPS, and MERI scores were collected. Hearing data were measured 1 day preoperatively, and 3 and 12 months postoperatively. Operation success was defined according to the Korean Society of Otology guidelines.

Results
For calculation of success, the ROC values of MERI were 0.551 at 12 months. ROC values of OOPS were 0.637 at 12 months. There were no significant differences in hearing variables among the three groups according to MERI. There were significantly favorable outcomes in hearing variables in the low-risk group in OOPS. The mean OOPS score was greater in patients with success than those with non-success. Otorrhea, ossicle status, and status of mucosa as variables in both indices were associated with success. The type of mastoidectomy as a variable in OOPS alone was associated with success. Absence of hypertension, presence of ossiculoplasty, and use of incus as ossiculoplasty material were associated with poor success rate.

Conclusion
Compared with MERI, the OOPS index was more closely associated with the hearing outcomes, which may be due to the extent of inflammation in the OOPS index.
Review of interruptions in a pediatric subspecialty outpatient clinic
Authors: Lee Tyler , Rosario Hinette , Cifuentes Elizabeth , Cui Jiawei , Lin Emery C. , Miller Victoria A. , Lin Henry C. 
Published: July 2021

Introduction
The objective of this study was to describe interruptions in the pediatric ambulatory setting and to assess their impact on perceived physician communication, patient satisfaction and recall of provided physician instructions.

Methods
An observational study was performed at the Children’s Hospital of Philadelphia, Pediatric Gastroenterology clinic. Participation consisted of video recording the clinic visit and the caregiver completed post-visit surveys on communication and satisfaction. Video recordings were coded for interruptions, which were divided into 3 main categories: Visit Associated, Pediatric Associated, and Unanticipated. An interruption rate was calculated and correlated with the following outcome variables to assess the impact of interruptions: caregiver satisfaction, caregiver perception on the quality of physician communication, and caregiver instruction recall.

Results
There were 675 interruptions noted in the 81 clinic visits, with an average of 7.96 (σ = 7.68) interruptions per visit. Six visits had no interruptions. The Patient was the most frequent interrupter. Significantly higher interruption rates occurred in clinic visits with younger patients (<7 years old) with most of the interruptions being Pediatric Associated interruptions. There was minimal correlation between the clinic visit interruption rate and caregiver satisfaction with the communication, caregiver perception of quality of communication, or caregiver instruction recall rate.

Conclusion
The effect of interruptions on the pediatric visit remains unclear. Interruptions may be part of the communication process to ensure alignment of the patient’s agenda. Additional studies are needed to help determine the impact of interruptions and guide medical education on patient communication.