bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Materi Pendidikan Agama Islam Berbasis Rumah
Authors: Suhardin Suhardin , Hayadin Hayadin , Sugiarti Sugiarti , Marlina Ani 
Published: December 2021

Abstract
This article aims to discuss the development of Islamic religious education materials available for parents at home. The significance of home-based materials was motivated by the paralysis of the school's function in serving the learning process, including children's religious education, when the COVID-19 outbreak hit the world. This article comes from research and development involving education stakeholders, especially teachers, supervisors, and parents. The activities in focus group discussions were carried out in three places, namely in Bandung, Serpong, and Surabaya. Awareness of the importance of minimal material for parents at home to teach and educate their children about Islam is one of the reasons why this research was conducted. The main question is, what is the minimum content of Islamic religious education that parents should teach at home. After going through a series of discussions at three workshop locations, it was concluded that the material for Islamic religious education at home should be more straightforward and complementary to the subject matter of Islamic religion at school. The materials include the creed of monotheism, aqidah (theology), which discusses Allah SWT; worship (ritual) includes prayer, fasting; muamalat, which includes the introduction of buying and selling and transactions in Islam; and morality.

Abstrak
Artikel ini bertujuan untuk mendiskusikan pengembangan materi minimal pendidikan agama Islam yang dapat digunakan oleh orang tua dan pendidik di rumah. Ini dilatarbelakangi oleh lumpuhnya fungsi sekolah dalam melayani proses pembelajaran termasuk pembelajaran pendidikan agama anak saat wabah covid-19 melanda dunia. Artikel ini berasal dari riset dan pengembangan yang melibatkan stake-holders pendidikan khususnya guru pendidikan agama Islam, pengawas pendidikan agama Islam, dan orang tua. Kegiatan pengembangan berbentuk fokus grup diskusi dilakukan pada tiga tempat yakni di kota Bandung, kota Serpong dan kota Surabaya. Kesadaran tentang pentingnya materi minimal bagi para orang tua di rumah untuk mengajar dan mendidik anaknya tentang agama Islam menjadi salah satu alasan mengapa riset ini dilakukan. Pertanyaan utamanya adalah, apa konten minimal pendidikan agama Islam yang harus diajarkan oleh orang tua di rumah. Setelah melewati serangkaian diskusi pada tiga lokasi workhop, disimpulkan bahwa materi pendidikan agama Islam di rumah mesti lebih sederhana, dan bersifat komplementer dengan materi pelajaran agama Islam di sekolah. Materi tersebut meliputi: akidah tauhid, aqidah (teologi) yang membahas tentang Allah SWT; peribadatan (ritual) mencakup Shalat, puasa, doa-doa; muamalat yang meliputi pengenalan jual beli dan transaksi dalam Islam; dan akhlaq.
Достовірність сортування радіаційно забруднених ґрунтів при виконанні земляних робіт на проммайданчику об’єкта "Укриття" Чорнобильської АЕС
Authors: Kondratyev S. , Kilina O. , Kadkin Ye. , Domnikov V. 
Published: December 2021

Розглянуто питання достовірного сортування радіаційно забрудненого ґрунту при виконанні земляних робіт на майданчику об'єкта "Укриття" під час будівництва нового безпечного конфайнменту. Запропоновано критерії достовірності сортування, засновані на вимогах до обмеження поточного та потенційного опромінення.
Запропоновано варіант сортування, заснований на вимірюванні картограми потужності експозиційної дози та обмеженні товщини шару одноразово добуваного ґрунту.
Підвищення надійності й безпеки розхолоджування гермооб'єма РУ АЕС з ВВЕР-1000
Authors: Balashevskiy A. , Gerliga A. , Miroshnichenko S. 
Published: December 2021

Розглянуто спосіб підвищення надійності й безпеки експлуатації РУ АЕС з ВВЕР-1000 в разі аварії з течею 1-, 2-го контура за допомогою струменевих розпилювачів-охолоджувачів без прямого зрошування устаткування реакторної установки від спринклерних пристроїв за рахунок модернізації штатної спринклерної системи.
Наведено схему й опис пропонованого способу. Представлено результати розрахункового аналізу зниження тиску в гермооб’ємі РУ АЕС для серійних енергоблоків ВВЕР-1000/В-320 і блоків «малої» серії ВВЕР-1000/В-302 на прикладі аварійної ситуації на енергоблоці № 3 Рівненської АЕС.
Результати експертного оцінювання стрес-тестів діючих енергоблоків АЕС України з урахуванням уроків аварії на АЕС «Фукусіма-1» в Японії
Authors: Gromov G. , Dybach A. , Zelenyi O. , Inyushev V. , Nosovsky A. , Sholomitsky S. , Shugailo A. , Gashev M. , Boichuk V. 
Published: December 2021

Відповідно до декларації Групи європейських регуляторів (ENSREG) експлуатуючими організаціями європейських країн під наглядом національних регулюючих органів з ядерної та радіаційної безпеки виконана цільова переоцінка безпеки АЕС з урахуванням уроків аварії на АЕС «Фукусіма-1» (стрес-тести).
У статті наведено короткий огляд міжнародних підходів, прийнятих при виконанні цільової переоцінки безпеки АЕС, а також основні висновки за результатами проведеної експертної оцінки стрес-тестів діючих енергоблоків АЕС України з урахуванням уроків аварії на АЕС Фукусіма-1.
Радіаційний вплив аварії на АЕС «Фукусіма-1» на довкілля та населення й побудоване на її наслідках оцінювання радіаційних ризиків від позапроектних аварій на АЕС з ВВЕР-1000
Authors: Barabashev S. , Skalozubov V. 
Published: December 2021

Наведено опис наслідків радіаційного впливу аварії на АЕС «Фукусіма-1» на довкілля та населення, перелічено контрзаходи та дії з аварійного реагування для населення.
Показано необхідність обліку аварій японського типу в процесі оцінювання радіаційних ризиків від позапроектних (тяжких) аварій на АЕС з ВВЕР-1000.
Надано деякі пропозиції, що спрямовані на підвищення безпеки діючих та майбутніх українських АЕС.
Оцінка системи вентиляції для централізованого сховища відпрацьованих джерел іонізуючого випромінювання
Authors: Soroka Yu. , Udod O. 
Published: December 2021

Проведено аналіз небезпеки поводження з відпрацьованими джерелами іонізуючого випромінювання в споруджуваному в Чорнобильській зоні відчуження централізованому сховищі. Запропоновано моделі для розрахунку можливих ситуацій, пов’язаних із забрудненням радіонуклідами приміщень сховища. Виконано розрахунки необхідної кратності повітрообміну для вентиляції приміщень при роботі з джерелами, що містять радіонукліди 60Co, 90Sr, 137Cs, 226Ra, 238Pu, 239Pu, 241Am.
На підставі розробленого зонування сховища та виконаних розрахунків наведено рекомендовані об’єми повітря загальнообмінної вентиляції приміщень централізованого сховища.
Photosynthetic Conversion of CO2 Into Pinene Using Engineered Synechococcus sp. PCC 7002
Authors: Yang Ruigang , Zhu Lingyun , Li Tao , Zhu Lv-yun , Ye Zi , Zhang Dongyi 
Published: December 2021

Metabolic engineering of cyanobacteria has received much attention as a sustainable strategy to convert CO2to various longer carbon chain fuels. Pinene has become increasingly attractive since pinene dimers contain high volumetric energy and have been proposed to act as potential aircraft fuels. However, cyanobacteria cannot directly convert geranyl pyrophosphate into pinene due to the lack of endogenous pinene synthase. Herein, we integrated the gene encodingAbies grandispinene synthase into the model cyanobacteriumSynechococcussp. PCC 7002 through homologous recombination. The genetically modified cyanobacteria achieved a pinene titer of 1.525 ± 0.l45 mg L−1in the lab-scale tube photobioreactor with CO2aeration. Specifically, the results showed a mixture ofα- andβ-pinene (∼33:67 ratio). The ratio ofβ-pinene in the product was significantly increased compared with that previously reported in the engineeredEscherichia coli. Furthermore, we investigated the photoautotrophic growth performances ofSynechococcusoverlaid with different concentrations of dodecane. The work demonstrates that the engineeredSynechococcusis a suitable potential platform forβ-pinene production.
Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy
Authors: Qin Yating , Lv Chao , Zhang Xinxin , Ruan Weibin , Xu Xiangyu , Chen Chen , Ji Xinyun , Lu Li , Guo Xiaomei 
Published: December 2021

Anthracyclines, such as doxorubicin (DOX), are among the effective chemotherapeutic drugs for various malignancies. However, their clinical use is limited by irreversible cardiotoxicity. This study sought to determine the role of neuraminidase 1 (NEU1) in DOX-induced cardiomyopathy and the potential cardio-protective effects of NEU1 inhibitor oseltamivir (OSE). Male Sprague–Dawley (SD) rats were randomized into three groups: control, DOX, and DOX + OSE. NEU1 was highly expressed in DOX-treated rat heart tissues compared with the control group, which was suppressed by OSE administration. Rats in the DOX + OSE group showed preserved cardiac function and were protected from DOX-induced cardiomyopathy. The beneficial effects of OSE were associated with the suppression of dynamin-related protein 1 (Drp1)-dependent mitochondrial fission and mitophagy. In detail, the elevated NEU1 in cardiomyocytes triggered by DOX increased the expression of Drp1, which subsequently enhanced mitochondrial fission and PINK1/Parkin pathway-mediated mitophagy, leading to a maladaptive feedback circle towards myocardial apoptosis and cell death. OSE administration selectively inhibited the increased NEU1 in myocardial cells insulted by DOX, followed by reduction of Drp1 expression, inhibition of PINK1 stabilization on mitochondria, and Parkin translocation to mitochondria, thus alleviating excessive mitochondrial fission and mitophagy, alleviating subsequent development of cellular apoptotic process. This work identified NEU1 as a crucial inducer of DOX-induced cardiomyopathy by promoting Drp1-dependent mitochondrial fission and mitophagy, and NEU1 inhibitor showed new indications of cardio-protection against DOX cardiotoxicity.
Multidisciplinary Team Managements and Clinical Outcomes in Patients With Pulmonary Arterial Hypertension During the Perinatal Period
Authors: Shu Tingting , Feng Panpan , Liu Xiaozhu , Wen Li , Chen Huaqiao , Chen Yunwei , Huang Wei 
Published: December 2021

Background: Pulmonary arterial hypertension (PAH) patients with pregnancy have high maternal mortality. This study aimed to provide clinical evidence with multidisciplinary team (MDT) management and to evaluate the clinical outcomes in PAH patients during the perinatal period.Methods: We conducted a retrospective evaluation of PAH patients pregnant at the First Affiliated Hospital of Chongqing Medical University between May 2015 and May 2021.Results: Twenty-two patients (24 pregnancies) were included in this study and received MDT management, and 21 pregnancies chose to continue pregnancy with cesarean section. Nine (37.5%) were first-time pregnancies at 27.78 ± 6.16 years old, and 15 (62.5%) were multiple pregnancies at 30.73 ± 3.71 years old. The average gestational week at hospitalization and delivery were 29.38 ± 8.63 weeks and 32.37 ± 7.20 weeks, individually. Twenty-one (87.5%) pregnancies received single or combined pulmonary vasodilators. The maternal survival rate of PAH patients reached 91.7%. Fifteen (62.5%) pregnancies were complicated with severe adverse events. Patients with complicated adverse events showed lower percutaneous oxygen saturation (SpO2), lower albumin, lower fibrinogen, higher pulmonary artery systolic pressure (PASP), higher blood pressure, longer activated partial thromboplastin time, and longer coagulation time. Fourteen (66.7%) pregnancies with cesarean sections were prematurely delivered and 85.7% newborns who survived after the operation remained alive.Conclusion: The survival rate of parturients with PAH was improved in relation to MDT and pulmonary vasodilator therapy during the perinatal period compared with previous studies. SpO2, albumin, PASP, blood pressure, and coagulation function should be monitored carefully in PAH patients during pregnancy.
Elevation of the Gangdese Mountains and Their Impacts on Asian Climate During the Late Cretaceous—a Modeling Study
Authors: Zhang Jian , Liu Yonggang , Fang Xiaomin , Zhang Tao , Zhu Chenguang , Wang Chengshan 
Published: December 2021

Uplift of the Gangdese Mountains is important to the evolution of Asian monsoons and the formation of Tibetan Plateau, but its paleoaltitude before the India-Asia collision (Late Cretaceous) is less constrained so far. In this study, we investigate whether the geological records, which are indicators of soil dryness, discovered in East Asia can provide such a constraint. Through climate modeling using the Community Earth System Model version 1.2.2, it is found that the extent of dry land in East Asia is sensitive to the altitude of the Gangdese Mountains. It expands eastwards and southwards with the rise of the mountain range. Comparison of the model results with all the available geological records in this region suggests that the Gangdese Mountains had attained a height of ∼2 km in the Late Cretaceous.
Trends and Climate Response in the Phenology of Crops in Northeast China
Authors: Xiao Dengpan , Zhang Yi , Bai Huizi , Tang Jianzhao 
Published: December 2021

Crop phenology is the process of crop growth and yield formation, which is largely driven by climatic conditions. It is vital to investigate the shifts in crop phenological processes in response to climate variability. Previous studies often only explored the response of a single crop phenology to climate change, and lacked comparative studies on the climate response in different crop phenology. We intend to investigate the trends in phenological change of three typical crops (i.e., maize, rice and soybean) in Northeast China (NEC) and their response to climate change during 1981–2010. Its main purpose is to reveal the differences in the sensitivity of different crop phenology to key climate factors [e.g., mean temperature (T), accumulated precipitation (AP) and accumulated sunshine hours (AS) during the crop growth period]. We found that the three crops have different phenological changes and varying ranges, and significant spatial heterogeneity in phenological changes. The results indicated that the lengths of different crop growth stages [e.g., the vegetative growth period (VGP), the reproductive growth period (RGP) and the whole growth period (WGP)] were negatively correlated with T, especially in VGP and WGP. However, the lengths of growth period of the three crops were positively correlated with AP and AS. For each 1°C increase in T, the number of days shortened in WGP (about 5 days) was the largest, and that in RGP (less than 2 days) was the smallest. Therefore, the increases in T during past 3 decades have significantly shortened VGP and WGP of three crops, but had slight and inconsistent effects on RGP. Moreover, changes in AP has slight impact on the growth periods of maize and rice, and significantly shortened RGP and WGP of soybean. Changes in AS exerted important and inconsistent effects on the phenology of three crops. This study indicated that there are significant differences in the sensitivity and response of different crop phenology to climate factors. Therefore, in evaluating the response and adaptation of crops to climate change, comparison and comprehensive analysis of multiple crops are helpful to deeply understand the impact of climate change on crop production.
Identification of a Risk Locus at 7p22.3 for Schizophrenia and Bipolar Disorder in East Asian Populations
Authors: Li Wenqiang , Zhang Chu-Yi , Liu Jiewei , Guan Fanglin , Shao Minglong , Zhang Luwen , Liu Qing , Yang Yongfeng , Su Xi , Zhang Yan , Xiao Xiao , Luo Xiong-Jian , Li Ming , Lv Luxian 
Published: December 2021

Background: Shared psychopathological features and mechanisms have been observed between schizophrenia (SZ) and bipolar disorder (BD), but their common risk genes and full genetic architectures remain to be fully characterized. The genome-wide association study (GWAS) datasets offer the opportunity to explore this scientific question using combined genetic data from enormous samples, ultimately allowing a better understanding of the onset and development of these illnesses.Methods: We have herein performed a genome-wide meta-analysis in two GWAS datasets of SZ and BD respectively (24,600 cases and 40,012 controls in total, discovery sample), followed by replication analyses in an independent sample of 4,918 SZ cases and 5,506 controls of Han Chinese origin (replication sample). The risk SNPs were then explored for their correlations with mRNA expression of nearby genes in multiple expression quantitative trait loci (eQTL) datasets.Results: The single nucleotide polymorphisms (SNPs) rs1637749 and rs3800908 at 7p22.3 region were significant in both discovery and replication samples, and exhibited genome-wide significant associations when combining all East Asian SZ and BD samples (29,518 cases and 45,518 controls). The risk SNPs were also significant in GWAS of SZ and BD among Europeans. Both risk SNPs significantly predicted lower expression of MRM2 in the whole blood and brain samples in multiple datasets, which was consistent with its reduced mRNA level in the brains of SZ patients compared with normal controls. The risk SNPs were also associated with MAD1L1 expression in the whole blood sample.Discussion: We have identified a novel genome-wide risk locus associated with SZ and BD in East Asians, adding further support for the putative common genetic risk of the two illnesses. Our study also highlights the necessity and importance of mining public datasets to explore risk genes for complex psychiatric diseases.
Degradation Behaviors of Two Epoxy Coatings After Dry/Wet-Accelerated Fog Exposure of Different Solutions
Authors: Zhang Jibiao , Zhu Bo , Wang Haoran , Zhang Cheng , Zeng Weixiu , Zhou Qixin 
Published: December 2021

Applying organic coating is an important and effective approach for the protection of metal from corrosion. Weathering degradation and under-film corrosion are the two major important factors that cause the failure of organic coatings. In this work, the degradation investigation of two epoxy coatings (clear and pigmented coatings) was carried out under the dry–wet circulation of three different water fog solutions (deionized water, 0.5 wt% NaCl, 0.05 wt% NaCl + 0.35 wt% (NH4)2SO4) in 35 days. The apparent performance (pull-off adhesion and surface potentials) and electrochemical features [electrochemical noise and electrochemical impedance spectroscopy (EIS)] of the coating samples were monitored after dry–wet fog exposure. In our three accelerating systems of the fog atmosphere, the time that the detectable defects appeared on the surface of coating samples was far ahead in the mixed salt solution than that in the deionized water or 0.5 wt% NaCl solution. For a defective or damaged coating surface, the derived results by using the standard deviation method (SDM) or Fourier power spectrum (FPS) were rather higher than those obtained from EIS as a whole, while for the same coating, the degradation trend with time derived from EIS, SDM, FPS, and scanning Kelvin probe was consistent with each other.
Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients
Authors: Wan Song , Xia Wen Qing , Zhong Yu Lin 
Published: December 2021

Background: Accumulating lines of evidence demonstrated that diabetic retinopathy (DR) patients trigger abnormalities in brain’s functional connectivity (FC), whereas the alterations of interhemispheric coordination pattern occurring in DR are not well understood. Our study was to investigate alterations of interhemispheric coordination in DR patients.Methods: Thirty-four DR individuals (19 males and 15 females: mean age: 52.97 ± 8.35 years) and 37 healthy controls (HCs) (16 males and 21 females; mean age: 53.78 ± 7.24 years) were enrolled in the study. The voxel-mirrored homotopic connectivity (VMHC) method was conducted to investigate the different interhemispheric FC between two groups. Then, the seed-based FC method was applied to assess the different FCs with region of interest (ROI) in the brain regions of decreased VMHC between two groups.Results: Compared with HC groups, DR groups showed decreased VMHC values in the bilateral middle temporal gyrus (MTG), lingual/calcarine/middle occipital gyrus (LING/CAL/MOG), superior temporal gyrus (STG), angular (ANG), postcentral gyrus (PosCG), inferior parietal lobule (IPL), and precentral gyrus (PreCG). Meanwhile, altered FC includes the regions of auditory network, visual network, default mode network, salience network, and sensorimotor network. Moreover, a significant positive correlation was observed between the visual acuity-oculus dexter (OD) and zVMHC values in the bilateral LING/CAL/MOG (r = 0.551, p = 0.001), STG (r = 0.426, p = 0.012), PosCG (r = 0.494, p = 0.003), and IPL (r = 0.459, p = 0.006) in DR patients.Conclusion: Our results highlighted that DR patients were associated with substantial impairment of interhemispheric coordination in auditory network, visual network, default mode network, and sensorimotor network. The VMHC might be a promising therapeutic target in the intervention of brain functional dysfunction in DR patients.
MN1 Neurodevelopmental Disease-Atypical Phenotype Due to a Novel Frameshift Variant in the MN1 Gene
Authors: Tian Qi , Shu Li , Zhang Pu , Zeng Ting , Cao Yang , Xi Hui , Peng Ying , Wang Yaqin , Mao Xiao , Wang Hua 
Published: December 2021

Background:MN1 C-terminal truncation (MCTT) syndrome is caused by variants in the C-terminal region of MN1, which were first described in 2020. The clinical features of MCTT syndrome includes severe neurodevelopmental and brain abnormalities. We reported on a patient who carried the MN1 variant in the C-terminal region with mild developmental delay and normal brain magnetic resonance image (MRI).Methods: Detailed clinical information was collected in the pedigree. Whole-exome sequencing (WES) accompanied with Sanger sequencing validation were performed. A functional study based on HEK239T cells was performed.Results: A de novo heterozygous c.3734delT: p.L1245fs variant was detected. HEK239T cells transinfected with the de novo variant showed decreased proliferation, enhanced apoptotic rate, and MN1 nuclear aggregation.Conclusion: Our study expended the clinical and genetic spectrum of MCTT which contributes to the genetic counseling of the MN1 gene.