bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of high‐pressure treatments on enzyme activity of fruit‐based beverages: an overview
Authors: Roobab Ume , Abida Afeera , Afzal Rehan , Madni Ghulam Muhammad , Zeng Xin‐An , Rahaman Abdul , Aadil Rana Muhammad 
Published: December 2021

SummaryWith an ever‐increasing demand for clean label products, there is a greater need for efficient and environmentally friendly processes to compete the conventional thermal or chemical treatments. For instance, high‐pressure processing (HPP) has been widely studied in the fruit industry from the last two decades. HPP can inactivate or activate different enzymes in fruit juices, pulp, and purées. HPP treatment inactivates the enzymes by the alterating the conformation of the protein structure and the active site. Depending on the enzyme, pressure, pH, temperature and treatment time, HPP can increase enzyme activity due to the release of membrane‐bound enzymes and also due to changes in protein conformation and active site that facilitate interaction with the substrate. Furthermore, the combination of high pressure, temperature and reduced treatment times offered greater inactivation of enzymes in fruit beverages. This study aimed to investigate the inactivation kinetics of endogenous enzymes in fruit beverages.
Soybean protein isolate‐rice starch interactions during the simulated gluten‐free rice bread making process
Authors: Hu Liang‐shu , Yang Yang , Chen Feng‐lian , Fan Jing , Wang Bing , Fu Yu , Bian Xin , Yu De‐hui , Wu Na , Shi Yan‐guo , Zhang Xiu‐min , Zhang Na 
Published: December 2021

AbstractGluten‐free bread (GFB) is usually of poor quality due to lack of gluten. Addition of exogenous protein is one of the important ways to improve the quality of GFB products. In this study, different levels of soybean protein isolate (SPI) mixed with rice starch (RS) system were prepared to simulate different processing stages during bread making. Differential scanning calorimetry (DSC), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), rapid viscosity analysis (RVA), confocal laser scanning microscopy (CLSM), texture analyser and rheometer were used to analyse the effects of SPI on the structural, microstructure and functional properties of RS. The results showed that: hydrogen bonds could be formed between SPI and RS, thus improving the stability of RS; compared with RS, the ∆H and setback values of the blend were reduced by 43.79% and 34.53%, respectively, when SPI was added at 12%; and the storage modulus (G') and loss modulus (G") reached the minimum value at 9% SPI content. CLSM and texture analysis show that the addition of protein inhibits the leaching of starch, reduces the hardness, chewiness and gumminess of the system, which is conducive to the quality of GFB.
High pressure‐based hurdle interventions for raw and processed meat: a clean‐label prospective
Authors: Roobab Ume , Afzal Rehan , Ranjha Muhammad Modassar Ali Nawaz , Zeng Xin‐An , Ahmed Zahoor , Aadil Rana Muhammad 
Published: December 2021

SummaryToday's consumers demand clean‐label healthy products to which no artificial preservatives have been added. Distribution of fresh, safe raw meat or meat products requires reduced numbers of bacteria on its surface when it leaves the processing plant under strict maintenance of low temperatures throughout the supply chain. Means of controlling or even improving the food integrity aim to decontaminate the carcasses or products during or at the end of the production line. In the past decades, high‐pressure processing (HPP) has been investigated as an alternative non‐thermal preservation technology to match all these demands without compromising safety. HPP treatments could efficiently inactivate the vegetative microorganisms (related to foodborne diseases), but not spores. However, the combination of several non‐thermal and conventional preservation techniques under the so‐called hurdle technology has been explored to enhance their efficiency.
Low‐dose thioguanine guided by therapeutic drug monitoring is a safe and effective alternative in inflammatory bowel disease patients intolerant to conventional thiopurines
Authors: Eqbal Ali , Martin Alicia , Doecke James D. , Patrick Desmond 
Published: December 2021

AbstractBackgroundThioguanine is an alternative thiopurine for inflammatory bowel disease (IBD) patients.AimsTo evaluate the short‐term efficacy and safety of low‐dose therapeutic drug‐monitored (TDM) thioguanine.MethodsA retrospective evaluation of IBD patients intolerant to conventional thiopurines started on thioguanine from 2017 to 2019 with dosing guided by TDM was conducted. Clinical response was defined for ulcerative colitis (UC) as a reduction of partial Mayo score ≥3 with reduction in rectal bleeding score of at least 1 and a final rectal bleeding subscore of 0–1 at Week 12 of therapy. Crohn disease (CD) response was defined as a reduction of Harvey‐Bradshaw index ≥3 (HBI) at Week 12 of therapy. Remission was defined in UC as partial Mayo score of <2 and in CD as HBI score of <5.ResultsForty‐six patients were included in the study. The median thioguanine dose was 20 mg/day (standard deviation 7.3; range: 10–40 mg/day) with a median 6‐thioguanine nucleotide level of 577 pmol/8 × 108 (interquartile range (IQR) IQR 378.5‐878.75) for CD and 677.5 pmol/8 × 108 (IQR 523.25‐842.25) for UC. The overall clinical response rate was 62% (13/21), intention to treat (ITT). Maintenance of remission was 76% (19/25, ITT). Thirty‐seven percent (17/46) of patients experienced an adverse effect. No early cases of nodular regenerative hyperplasia (NRH) were seen.ConclusionThioguanine was tolerated well in 63% of patients. A clinical response was seen in 62% of patients, and maintenance of remission was high at 76%. No cases of early NRH were seen. Longer‐term follow up is required to ensure safety and to assess durability of response.
Mutuality in nursing: A conceptual framework on the relationship between patient and nurse
Authors: Cilluffo Silvia , Bassola Barbara , Pucciarelli Gianluca , Vellone Ercole , Lusignani Maura 
Published: December 2021

AbstractAimsTo describe and develop a conceptual framework for the process of mutuality between nurse and patient.DesignThis was a qualitative study with a grounded theory (GT) design following the constructivist approach of Charmaz (SAGE handbook of research, 2014).MethodsA sample of 33 patients with one or more chronic diseases and 35 nurses were interviewed between July and October 2020. Comparative and simultaneous data analyses were conducted. Theoretical sampling and saturation of categories were used to define the sample size.ResultsA conceptual framework for mutuality between nurse (mean age 42 SD ±7 years, 89% female) and patient (mean age 63 SD ±8 years, 42% female) was developed, including the mutuality process, potential influencing factors for both nurses and patients, and outcomes. The mutuality process was characterised by three dimensions: developing and going beyond, being a reference, and deciding and sharing care. Influencing factors for nurses were personal characteristics and professional organisation, while for patients these were age and past experiences. Nurse outcomes were satisfaction and quality of life; patient outcomes were improved self‐care and reduction of hospitalisation and emergency admissions.ConclusionThis study described a new conceptual framework for mutuality between nurse and patient, which could improve our understanding of the relationship between nurses and patients, thus enhancing both nurse and patient outcomes.
Reproductive dynamics of the invasive lionfish (Pterois miles) in the Eastern Mediterranean Sea
Authors: Mouchlianitis Foivos A. , Kalaitzi Georgia , Kleitou Periklis , Savva Ioannis , Kletou Demetris , Ganias Kostas 
Published: December 2021

AbstractThe lionfish Pterois miles invaded the Mediterranean Sea in 2012 and spread fast to the entire eastern basin. This study provides evidence of successful spawning and the first detailed analysis of P. miles ovarian dynamics in the Mediterranean Sea. The ovarian reproductive phases of mature females collected from Cyprus (eastern Mediterranean) between September 2017 and August 2018 were analysed, both macroscopically and histologically. The results suggested a prolonged oocyte recruitment and development season, and a spawning season that primarily occurred during summertime, even though spawning‐capable females were caught also in autumn. A year‐round spawning activity may have been inhibited due to seasonal variations in water temperature. Multiple oocyte developmental stages co‐occurred in females at different reproductive phases, indicating that more than one oocyte batches were released per spawning season. The analysis of the spawning batch formation enabled the batch fecundity estimation at 3225–63149 oocytes. The oocyte development pattern described in this study shared characteristics with the indeterminate fecundity type, where new oocytes are recruited to the secondary growth phase in parallel with spawning activity. Climate change is likely to extend the spawning season of lionfish in the Mediterranean Sea and further favour its invasion. The information provided in this study is vital for the design of strategic and effective management plans to restrain the expansion of this highly invasive fish.
A structural equation modeling of reproductive health promoting behaviors among female adolescents in the Philippines
Authors: Choi Yoona , Lee Taewha 
Published: December 2021

AbstractAimsIntegrated reproductive health promoting behaviors, including safe sexual intercourse, preventing sexually transmitted diseases, sexual responsibility, and genital health management, are essential for adolescents in developing countries. The Philippines is currently facing several reproductive health threats. The aim of this study was to identify factors affecting reproductive health promoting behaviors based on a theoretical model using structural equation modeling.MethodsIn this cross‐sectional study and a structural equation modeling, a total of 227 female adolescents in the Philippines participated in a self‐reported questionnaire survey.ResultsThe results indicated that reproductive health knowledge (β = .14, p = .033), attitudes regarding reproductive health behaviors (β = .31, p = .027), and reproductive health self‐efficacy (β = .31, p = .002) influenced participants' reproductive health promoting behaviors. Social norms (β = .31, p = .021) influenced reproductive health self‐efficacy and indirectly influenced reproductive health promoting behaviors. Attitude toward gender roles (β = .20, p = .020) was associated with reproductive health knowledge.ConclusionsThis study confirmed the direct effect of reproductive health knowledge, attitudes regarding reproductive behaviors, and reproductive health self‐efficacy, as well as the indirect effect of social norms, on reproductive health promoting behaviors using structural equation modeling.
Effects of telehealth interventions on performing activities of daily living and maintaining balance in stroke survivors: A systematic review and meta‐analysis of randomised controlled studies
Authors: Saragih Ita Daryanti , Tarihoran Dame Elysabeth Tuty Arna Uly , Batubara Sakti Oktaria , Tzeng Huey‐Ming , Lin Chia‐Ju 
Published: December 2021

AbstractBackgroundStroke is one of the most common causes of disability worldwide. In recent years, diverse telehealth programmes for stroke survivors have suggested that this mode of rehabilitation could improve stroke survivors’ abilities to perform activities of daily living (ADLs) and maintain balance. Although increasingly utilised in clinical and community settings, the effectiveness of telehealth interventions in stroke survivors remains inconclusive. This warrants investigation so that telehealth interventions are evidence‐based and are not merely modalities of convenience.AimTo identify the effects of telehealth interventions on the ability to perform ADLs and maintain balance in stroke survivors.DesignA systematic literature review and meta‐analysis were conducted in accordance with PRISMA guidelines.MethodsA systematic literature search was performed using seven databases for literature dated up to April 25, 2021. The revised Cochrane risk of bias tool for randomised trials was used to assess the methodological quality of the included studies. A meta‐analysis was performed using a random‐effects model to calculate the pooled effects of telehealth interventions. Stata 16.0 was used for the statistical analyses.ResultsA total of 14 studies with 1,367 participants were included in the analysis. Overall, telehealth interventions were effective in improving stroke survivors’ abilities to carry out their ADLs (standardised mean difference: .45; 95% confidence interval: .12 to .78); however, no significant effects were found on balance.ConclusionTelehealth interventions are beneficial for improving stroke survivors’ performance of their ADLs. Future telehealth intervention trials should focus on identifying essential intervention delivery components that facilitate intervention adoption by clinicians and stroke survivors and sustain the positive effects on stroke survivors’ performance of their ADLs in different settings.Relevance to clinical practice.It is essential to build flexibility in the telehealth‐based intervention delivery protocol to meet individual stroke survivors’ needs to motivate and enhance their ADL performance.
Seeing the complete picture: A systematic review of mental health consumer and health professional experiences of diagnostic overshadowing
Authors: Molloy Renee , Brand Gabrielle , Munro Ian , Pope Nicole 
Published: December 2021

AbstractAimTo systematically identify, explore and synthesise qualitative data related to mental health consumer and health professional experiences of diagnostic overshadowing.BackgroundMental health consumers experience significantly high rates of physical illness, poorer health outcomes and are more likely to die prematurely of physical illnesses than the general population. Diagnostic overshadowing is a complex and life‐threatening phenomenon that occurs when physical symptoms reported by mental health consumers are misattributed to mental disorders by health professionals. This typically occurs in general healthcare settings.MethodsDrawing on JBI methodology for systematic reviews, four scholarly databases and grey literature was searched, followed by eligibility screening and quality assessment using JBI QARI frameworks, resulting in six studies for inclusion. Findings were synthesised using meta‐aggregation. The PRISMA checklist was adhered to throughout this process.FindingsFive synthesised findings emerged. Three from the health professional experience: working in ill‐suited healthcare systems, missing the complete diagnostic picture, and misunderstanding the lived experience of mental illness. Two from the mental health consumer experience: not knowing if the cause is physical or mental, and surviving and ill‐suited health care system.ConclusionsDiagnostic overshadowing is a multidimensional experience of interconnecting factors including systematic healthcare system issues, health professionals limited mental health knowledge and skills, stigmatic attitudes and mental health consumers miscommunicating their physical healthcare needs. Further research is needed to make diagnostic overshadowing visible and mitigate against this phenomenon that deprives mental health consumers of equitable access to quality healthcare.Relevance to clinical practiceThose who govern healthcare systems have an obligation to recognise and address the unique needs of mental health consumers who seek help for physical illnesses to ensure they receive quality and safe care. Forming collaborative partnerships with mental health consumers in the development of knowledge translation initiatives targeting healthcare policy, practice and education are urgently required.
Theories and definitions of the informal economy: A survey
Authors: Dell'Anno Roberto 
Published: December 2021

AbstractThis paper surveys the literature on the definitions and theories of the informal economy (IE). It outlines the main differences in the definitional approaches of informality and proposes a definition for the IE that may be consistent with measurement and policy. The literature review distinguishes three, not mutually exclusive, approaches to the IE: the “neoclassical,” the “macro‐econometric,” and the “conceptual” perspectives. I conclude the survey by outlining a framework that points out the main differences and similarities among the schools of thought on the nature of the IE. From a normative perspective, a leading recommendation emerges: a “one‐size‐fits‐all” policy response is inadequate to deal with the heterogeneous nature of the IE. Policy measures should be tailored around the distinct segments of the IE grounded in terms of characteristics, contexts, and needs of the informal units.
Adherence to a vegetable dietary pattern attenuates the risk of non‐alcoholic fatty liver disease in incident type 2 diabetes: The TCLSIH cohort study
Authors: Xia Yang , Cao Limin , Zhang Qing , Liu Li , Zhang Shunming , Meng Ge , Wu Hongmei , Gu Yeqing , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Wu Qijun , Niu Kaijun , Zhao Yuhong 
Published: December 2021

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) is a strong risk factor for type 2 diabetes. However, no study has investigated whether dietary intake can modify this effect. Therefore, we aimed to investigate the effect of dietary pattern modification on the association between NAFLD and type 2 diabetes.MethodsA large prospective cohort study (n= 24,602) was conducted in China. NAFLD was diagnosed using liver ultrasonography considering alcohol consumption. Dietary data were assessed using a validated self‐administered food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsFollowing a 93,873 person‐year follow‐up, 787 (3.20%) participants developed type 2 diabetes. In a multivariable adjusted model, compared with participants without NAFLD, the HR (95% CI) of incident type 2 diabetes for NAFLD patients was 3.04 (2.51, 3.68). On subgroup analyses, the adjusted HRs (95% CIs) of incident type 2 diabetes for NAFLD patients with low (≤median score) and high (>median score) vegetable pattern intakes were 4.08 (3.05, 5.46) and 2.38 (1.85, 3.07) (pfor interaction <0.01), respectively. Higher vegetable intake was also found to attenuate the risk effect of phenotype groups of NAFLD on incident type 2 diabetes, especially in the lean NAFLD group.ConclusionsThe present study demonstrated that NAFLD is a strong risk factor for type 2 diabetes in the Chinese population. Notably, adherence to a dietary pattern rich in vegetables can attenuate this risk, especially in lean NAFLD patients.
Genome mining andIn‐silicodetermination of secondary metabolites of bacteria againstFusarium oxysporumf. sp.Lycopersici
Authors: Sonkar Preeti , Odumosu Bamidele Tolulope , Kamaluddin  
Published: December 2021

AbstractFusarium wilt caused byFusarium oxysporumf. sp.lycopersici(FOL) is a devastating global plant fungal disease particularly in tomatoes leading to serious economic losses. The aim of this study was to determine anin silicoeffective antifungal metabolite against two important FOL proteins. Anin silicoligand–protein interaction was carried out by genome mining and molecular docking of the best ligand‐producing strains of bacteria using AutoDock and antiSMASH tools. The secondary metabolites obtained from different bacteria selected for biocontrol agents (BCA) were docked against SIX and TOM proteins. The selected compounds were docked in the active site of both proteins while random starting positions, torsion angles were established for all ligands. Based on the protein–ligand interactions, the best inhibitor of SIX and TOM protein was xanthobaccine A fromLysobactersp. strain SB‐K88. On the other hand, the best BCAs compound was heat‐stable antifungal factor obtained fromL. enzymogenes, viginiafactin (Pseudomonassp. QS1027), massetolide A (P. fluorescenss5101), bicorlnutin A1 and A2 (Xenorhabdusbudapestensis) which showed similarity scores viz., 1.25 (with domain NRP, Polyketide), 1.09 (NRP domain), 1.06(NRP domain), 1.00 (NRP domain). The results of our findings suggestLysobactersp. as a good biocontrol agent with active biosynthetic gene clusters and as a suitable substitute for agrochemicals. The output of this study will be useful in future management ofF. oxysporumf. sp.lycopersiciwith other plant pathogen and help in crop improvement.
Echocardiographic reference intervals for right ventricular indices, including 3‐dimensional volume and 2‐dimensional strain measurements in healthy dogs
Authors: Feldhütter Elisabeth K. , Domenech Oriol , Vezzosi Tommaso , Tognetti Rosalba , Sauter Nadja , Bauer Alexander , Eberhard Jenny , Friederich Jana , Wess Gerhard 
Published: December 2021

AbstractBackgroundThere is currently a lack of reference intervals (RIs) for the novel measures like 3‐dimensional (3D) echocardiography or speckle‐tracking strain for assessment of right ventricular (RV) structure and function.ObjectivesTo generate RIs and to determine the influence of age, heart rate, and body weight (BW) on various RV function indices using a dedicated RV software for 3D RV end‐diastolic volume (EDV), end‐systolic volume (ESV), ejection fraction (EF), global and free wall RV longitudinal strain (RVLS), end‐diastolic area (RVEDA), end‐systolic area (RVESA), fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), and tissue Doppler imaging (TVI)‐derived systolic myocardial velocity of the lateral tricuspid annulus (S′).AnimalsHealthy adult client‐owned dogs (n = 211) of various breeds and ages.MethodsProspective study. Reference intervals were estimated as statistical prediction intervals using allometric scaling for BW‐dependent variables. Right‐sided (upper limit) or left‐sided (lower limit) 95% RIs were calculated for every variable. Inter‐ and intraobserver variability was determined.ResultsMost variables showed clinically acceptable repeatability with coefficient of variation less than 10. Upper or respectively lower RI after allometric scaling to normalize for different BWs were: EDVn ≤ 2.5 mL/kg0.942, ESVn ≤ 1.2 mL/kg0.962, TAPSEn ≥ 4.5 mm0.285, RVEDAn ≤ 1.4 cm2/kg0.665, RVESAn ≤ 0.8 cm2/kg0.695, and TVI S′n ≥ 5.6 cm/s/kg0.186. The calculated limits for indices without allometric normalization were: EF > 42.1%, FAC > 30.0%, free wall RVLS < −20.8%, and global RVLS < −18.3%.ConclusionsEchocardiographic RIs for RV structure and function are provided.
Relationship between psychopathic traits and moral sensitivity in a university student sample
Authors: Costa Bárbara de Jesus , Azevedo Maria da Conceição , Relva Inês Carvalho , Simões Alice Margarida 
Published: December 2021

AbstractPurposeThis study aims to analyse the relationship between psychopathic traits and moral sensitivity. Theoretically it is said that amoral behaviour characterizes individuals with psychopathy, and it is expected that they do not follow the rules, being devoid of moral sensitivity.MethodThus, it was intended to: investigate the differences in psychopathy and moral sensitivity according to gender; analyse the associations between psychopathy and moral sensitivity and explore the relationship between moral sensitivity and psychopathic traits. The sample consisted of 520 university students aged between 17 and 49 years (M = 20.69; SD = 3.67). For data collection, the Self‐Report Psychopathy Scale ‐ III (SRP‐III), the Ethical Sensitivity Scale Questionnaire (ESSQ) and a socio‐demographic questionnaire were used.ResultsIt was concluded that psychopathy is negatively associated with moral sensitivity.ConclusionsIt is possible to observe the importance that moral sensitivity plays as it can function as a protective factor in the development of psychopathic traits.