bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Pre-Operative Breast Magnetic Resonance Imaging (MRI) on Contralateral Synchronous and Metachronous Breast Cancer Detection- A Case Control Comparison Study With Mean Follow-Up of 102 Months.
Authors: Wu Wen-Pei , Chen Chih-Yu , Lee Chih-Wei , Wu Hwa-Koon , Chen Shou-Tung , Wu Yu-Ting , Lin Ying-Jen , Chen Dar-Ren , Kuo Shou-Jen , Lai Hung-Wen 
Published: January 2021

Abstract
Background: Women with unilateral breast cancer are at an increased risk for the development of contralateral breast cancers. We hypothesis that combined breast MRI would detect more contralateral synchronous breast cancer than conventional imaging alone, and resulted in less contralateral metachronous breast cancer during follow-up. Methods: In this case control analysis, we retrospectively collected two groups of patients for evaluating the effectiveness and value of adding pre-operative breast MRI to conventional breast images (mammography and sonography) for detection of contralateral synchronous breast cancer. The new metachronous contralateral breast cancer diagnosed during follow-up was prospectively evaluated and compared. Results: Group A (n=733) comprised patients who underwent conventional preoperative imaging and group B (n=735) combined with MRI were enrolled and compared. Seventy (9.5%) of the group B patients were found to have contralateral lesions detected by breast MRI, and 65.7% of these lesions only visible with MRI. The positive predictive value of breast MRI detected contralateral lesions was 48.8%. With the addition of breast MRI to conventional imaging studies, more surgical excisions were performed in contralateral breasts (6% (44/735) versus 1.4% (10/733), P< 0.01), more synchronous contralateral breast cancer detected (2.9% (21/735) versus 1.1% (8/733), P=0.02), and resulted in numerical less (2.2% (16/714) versus 3% (22/725), p=0.3) metachronous contralateral breast cancer during a mean follow-up of 102 months. Conclusions: Combining pre-operative breast MRI evaluation resulted in an increase of contralateral synchronous breast cancer detection, and a numerical less subsequent contralateral metachronous breast cancer occurrence compared to conventional imaging alone.
Association Between Socio-Environmental Factors, Coverage by Family Health Teams, and Rainfall in the Spatial Distribution of Zika Virus Infection in the City of Rio de Janeiro, Brazil, in 2015 and 2016
Authors: Raymundo Carlos Eduardo , Medronho Roberto de Andrade 
Published: January 2021

Abstract
Background: Zika virus (ZIKV) infection caused outbreak in Brazil, in 2015 and 2016. Disorganized urban growth, facilitates the concentration of numerous susceptible and infected individuals. It is useful to understand the mechanisms that can favor the increase in ZIKV incidence, such as areas with wide socioeconomic and environmental diversity. Therefore, the study analyzed the spatial distribution of ZIKV in the city of Rio de Janeiro, Brazil, in 2015 and 2016, and associations between the incidence per 1,000 inhabitants and socio-environmental factors. Methods: The census tracts were used as the analytical units reported ZIKV cases among the city’s inhabitants. Local Empirical Bayesian method was used to control the incidence rates’ instability effect. The spatial autocorrelation was verified with Moran’s Index and local indicators of spatial association (LISA). Spearman correlation matrix was used to indicate possible collinearity. The Ordinary Least Squares (OLS), Spatial Lag Model (SAR), and Spatial Error Model (CAR) were used to analyze the relationship between ZIKV and socio-environmental factors.Results: The SAR model exhibited the best parameters: R2 = 0.44, Log-likelihood= -7482, Akaike Information Criterion (AIC) = 14980. In this model, mean income between 1 and 2 minimum wages was possible risk factors for Zika occurrence in the localities. Household conditions related to adequate water supply and the existence of public sewage disposal were associated with lower ZIKV incidence rates, suggesting possible protective factors against the occurrence of ZIKV in the localities. The presence of the Family Health Strategy in the census tracts was positively associated with the ZIKV incidence rate. However, the results show that mean income less than 1 minimum wage were negatively associated with higher ZIKV incidence rates. Discussion: The results demonstrate the importance of socio-environmental variables in the dynamics of ZIKV transmission and the relevance for the development of control strategies.
Development and evaluation of a handheld type 6 DoF midair haptic device using asymmetric vibration and a presentation force vectoring mechanism
Authors: Okuda Yuto , Komizunai Shunsuke , Konno Atsushi 
Published: January 2021

Abstract
This paper describes a handheld type aerial haptic device with 6 DoF (degree of freedom) using pseudo-haptics by asymmetric vibration. By introducing a original presentation force vectoring mechanism, 6 DoF force sense presentation and compactness suitable for handheld use with a small number of vibrators are realized together. In addition, a relationship between the drive input and output (presentation force sense) of the developed device is formulated, and its inverse problem solving method for obtaining the drive input that realizes a desired presentation force sense is derived. Furthermore, a user test clarified the direction in which this device can / cannot effectively exert force.
Barriers and Facilitators to Implementing a Stepped Care Cognitive-behavioral Therapy for Insomnia in Cancer Patients: a Qualitative Study.
Authors: Savard Josée , Filion Catherine , Gagnon Marie-Pierre , Caplette-Gingras Aude , Bélanger Lynda , Morin Charles M. 
Published: January 2021

Abstract
Background: Insomnia affects between 30 to 60% of cancer patients and tends to become chronic when left untreated. Cognitive-behavioral therapy for insomnia (CBT-I) is the recommended first-line treatment for cancer-related insomnia. Yet, this treatment is not readily accessible. A stepped care intervention beginning with a self-administered (web-based) intervention appears to be a promising cost-effective approach to offer CBT-I in routine cancer care as compared to a standard face-to-face therapy. This qualitative study investigated current practices in the assessment and management of insomnia in five hospitals offering cancer care and identified the barriers and facilitators to the implementation of a stepped care CBT-I in these clinical settings. Methods: Nine focus groups composed of a total of 43 clinicians (e.g., physicians, nurses, nurse navigators, technologists, psychologists) and administrators, as well as 10 cancer patients were held. The Consolidated Framework for Implementing Research was used to develop the semi-structured interview and analyze the data. Results: Sleep difficulties are not systematically discussed in clinical practice and when a treatment is offered, most often, it is a pharmacological one. Based on the Consolidated Framework for Implementing Research, barriers to the implementation of a stepped care CBT-I included individual characteristics (e.g. lack of knowledge about CBT-I among cancer care providers, patients’ comorbidities and preferences); intervention characteristics (e.g., lack of internet access); inner setting characteristics (e.g., lack of time and resources, resistance to change); and process factors (e.g., need for prior training and engagement of all stakeholders). Facilitators were related to individual characteristics (e.g. strong beliefs in the efficacy of CBT-I); intervention characteristics (e.g. web-based format that increases accessibility at a lower cost, short- and long-term effects of CBT-I); and process factors (e.g. high motivation and commitment to offer a new service to patients). Conclusions: This qualitative study confirms the need to better address insomnia in routine cancer care and suggests that, while some barriers were mentioned, the implementation of a stepped care CBT-I is feasible provided that some conditions are met such as prior training and engagement of all stakeholders from the outset.
Factors associated with perceived stress of clinical practice among associate degree nursing students in Taiwan
Authors: Wu Chia-Shan , Rong Jiin-Ru , Huang Mei-zen 
Published: January 2021

Abstract
BackgroundClinical placements play an important role in helping nursing students to achieve clinical competence, but these placements can be highly challenging and stressful. It has been shown that stress can be either a trigger or aggravating factor for ill-health in general, but studies have seldom differentiated the impact of general health status on perceived stress. This study examined factors associated with perceived stress of clinical practice among nursing students with a particular focus on the effect of general health status on stress.MethodsThis was a cross-sectional quantitative study conducted among 724 associate nursing degree students in Southern Taiwan. ResultsHealth status scores varied from 28-139, with an average of 68.40 (SD = 25.75). Health status was reported to be ‘good’ (scores 28-55) in 35.5% of participants, moderate (scores 56–83) in 24.6%, and poor (Scores ≧ 84) in 39.9% of participants. Perceived stress scores ranged from 0-95 points with an average score of 36.65 (SD ± 15.95). The CART analysis showed health status as the most important factor linked to perceived stress with a Normalized Importance value of 100%. Those who reported general health status (measured through GHQ-28 ) score of ≤ 34.5 perceived mild stress and those with a score of >34.5–<84.5 perceived moderate stress. A score of 84.5 was found to be the point of transition to perceptions of severe stress. When health status score was greater than 84.5, perceived stress was at a severe or extremely severe level. ConclusionsOur findings indicated health status as a potential measure to identify students who were most vulnerable to perceived stress. Given the cross-sectional design of this study and the bidirectional relationship between health and stress, more studies are needed to fully establish the predictive link between general health status and vulnerability to stress.
Effect of "motivational interviewing" and "information, motivation and behavioral skills” on choosing mode of delivery in pregnant women: A randomized controlled trial
Authors: Shirzad Mahboubeh , Shakibazadeh Elham , Foroushani Abbas Rahimi , Abedini Mehrandokht , Poursharifi Hamid 
Published: January 2021

Abstract
Background: Cesarean section is an important surgical procedure to save mothers and/or babies’ lives. Current trends show that the rate of Cesarean section is increasing dramatically over the years. The aims of this study were to compare the effects of "motivational interviewing" and "information, motivation and behavioral skills” model on choosing mode of delivery among pregnant women.Methods: In a four-armed, parallel-design randomized controlled trial, 120 women were randomly assigned to three brief interventions and one control groups. We recruited pregnant women referring to Ebnesina hospital, Tehran- Iran from 2019-2020. The intervention groups included: 1) motivational interviewing; 2) face-to-face information, motivation and behavioural skills model; and 3) information, motivation and behavioural skills model provided using a mobile application. The control group received usual antenatal care. The inclusion criteria were being literate, gestational age 24 to 32 weeks at recruitment, being able to speak Persian, having no complications in the current pregnancy, having no indications for CS, and having enough time to participate in the intervention sessions. The primary outcome of the study was mode of delivery. The secondary outcomes included women’s intentions to undergo any mode of delivery and women’s self-efficacy in choosing the mode of delivery. Data were analyzed using descriptive statistics (mean, frequency and standard deviation), inferential statistics including independent t-test, paired t-test, Chi-squared and One-way ANOVA tests.Results: Following the interventions, significant differences were found in the mode of delivery (P < 0.05) and women’s self-efficacy and intention (P < 0.05). Women who had used the mobile application had more improvements in the self-efficacy and intention than the face-to-face intervention groups.Conclusions: Our study showed positive significant effects of various types of brief interventions to reduce unnecessary Cesarean section rate among the participant women. Providing the intervention using mobile application showed even better results. Our findings may contribute to a rise in normal vaginal delivery; and these simple, non-expensive, tailored to women, and culture-oriented brief interventions can be considered as appropriate strategies to reduce Cesarean section rate in local, national, and/or regional levels.
Association of meat consumption with NAFLD risk and liver-related biochemical indexes in older Chinese: a cross-sectional study
Authors: Peng Hewei , Xie Xiaoxu , Pan Xinting , Zheng Jing , Zeng Yidan , Cai Xiaoling , Hu Zhijian , Peng Xian-E 
Published: January 2021

Abstract
Background: Non-alcohol fatty liver disease (NAFLD) is the most common liver disease and an unhealthy lifestyle can lead to an increased risk of NAFLD. The present study aims to evaluate the association of meat consumption with NAFLD risk and liver-related biochemical indexes in middle-aged and elderly Chinese.Methods: A cross-sectional study was conducted in individuals who were 45 years or older and underwent a physical examination from April 2015 to August 2017 in Southeast China. To evaluate associations between meat intake and NAFLD risk, inverse probability of treatment weighting and subgroup analyses were performed with logistic regressions. Spearman’s rank correlation was carried out to examine the relationship between meat consumptions and liver-related biochemical indexes. Results: High consumptions of red meat (28.44-49.74 and >71.00 g/day) (ORadjusted=1.948; P<0.001; ORadjusted=1.714; P=0.002) was positively associated with NAFLD risk on inverse probability of treatment weighting analysis, adjusting for smoking, tea intake, weekly hours of physical activity and presence of hypertension, dyslipidemia and diabetes. Exposure-response relationship analysis presented that red meat intake was positively associated with NAFLD risk. Significant associations of red meat intakes with serum levels of γ-glutamyl transferase, alanine transaminase, aspartate aminotransferase, total triglyceride and high-density lipoprotein cholesterol were found (rs=0.176; P<0.001; rs=0.128; P<0.001; rs=0.060; P=0.016; rs=0.085; P=0.001; rs=-0.074; P=0.003). Conclusions: These findings suggest that the reduction of meat consumption may decrease NAFLD risk and should warrant further investigations.
LncRNA MNX-AS1 combined with YBX1 to promote bladder cancer proliferation, migration, and invasion through activiting Wnt signaling pathway
Authors: Hu Hailong , Wu Zhouliang , Shen Chong , Da La , Zhao Gangjian , Zuo Songlin , Tian Dawei 
Published: January 2021

Abstract
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. Bladder cancer is one of the most common genitourinary malignancies, and its proliferation, migration and invasion also regulated by many functional lncRNAs. In our study, we found that lncRNA MNX1-AS1 was highly-expressed in bladder cancer tissues and cell lines. Moreover, higher MNX1-AS1 expression was correlated with poor survival of MNX1-AS1 patients. Mechanistically, we showed that MNX1-AS1 could interact with YBX1 and promotes its location at the promoter region of β-catenin, then to promote transcriptional activation of β-catenin. In addition, MNX1-AS1/YBX1 could promote bladder cancer cells proliferation, migration and invasion through active Wnt/β-catenin signaling by induce β-catenin transcriptional activation. Consistently, we find a new functional lncRNA MNX1-AS1 can regulate bladder cancer cells proliferation, migration and invasion by target β-catenin transcriptional activation together with YBX1.
Psychological factors influencing the formation of therapeutic cooperation in pulmonary tuberculosis patients undergoing in-patient treatment
Authors: Zolotova N. V. , Streltsov V. V. , Baranova G. V. , Kharitonova N. Yu. , Bagdasaryan T. R. 
Published: January 2021

The objective of the study: the comparative study of psychological characteristics of pulmonary tuberculosis patients with different levels of therapeutic cooperation during in-patient treatment.Subjects and nethods. 318 pulmonary tuberculosis patients aged 18-60 years old were enrolled in the study; they all underwent in-patient treatment in Central Tuberculosis Research Institute in 2017-2019, of them 195 (61.3%) were women and 123 (38.7%) were men. In all patients, the level of therapeutic cooperation was studied using the specially designed questionnaire; psychological characteristics were assessed using certain psychodiagnostic methods.Results. It was found that the proportion of patients with a high level of therapeutic cooperation (44.3% of cases) significantly prevailed versus patients with low (29.6% of cases) (Pearson χ2 = 9.4; p < 0.01) and moderate level of cooperation (26.1% of cases) (Pearson χ2 = 15.02; p < 0.001). A comparative study of the psychological characteristics of pulmonary tuberculosis patients demonstrating different levels of therapeutic cooperation allowed identifying psychological prognostic parameters of therapeutic cooperation, the main of which were the severity of suspicion, negative affective states (irritability, aggressiveness), distrustful-skeptical style of interaction, confrontation with others, as well as the level of quality life, primarily the emotional and social aspects of functioning. The detected psychological differences are considered as targets of psychological work focused on the formation of appropriate therapeutic cooperation during in-patient treatment.
Rendimiento empresarial sostenible para las micro, pequeñas y medianas empresas en Colombia
Authors: Pelekais Elmar Aldrin , Ortega Carvajalino Daniela Vanessa 
Published: January 2021

El presente trabajo tiene como finalidad delinear la importancia de las micro, pequeñas y medianas empresas en Colombia y describir la importancia del concepto de sostenibilidad en el rendimiento empresarial de las MIPYMES en el país, así como desarrollar los factores y las ventajas del concepto de sostenibilidad y desarrollo sostenible que influyen en la eficiencia empresarial. Se utilizó el método descriptivo documental, recopilando información de tesis, revistas, catálogos, documentos de Internet, realizando una verificación de los documentos actualizados del tema, así como los avances en el estudio del rendimiento empresarial con una visión de desarrollo sostenible. Finalmente se concluyó la importancia que ha tenido incluir el concepto de sostenibilidad en la MIPYMES de Colombia, ya que para su implementación no se ha tenido que hacer grandes inversiones de capital, ni personal; comenzando a dar resultados en el cambio de pensamiento de la población y mejorando los rendimientos empresariales de este tipo de empresas con un nuevo sistema económico sostenible.
Palabras clave: Rentabilidad; rendimiento empresarial; sostenibilidad; micro, pequeñas y medianas empresas (mipymes); medio ambiente; desarrollo sostenible.
Editando en medio de la pandemia
Authors: Blanco-Rangel Ibelis , Guerrero Blanco Nahomy 
Published: January 2021

En marzo de 2020, el director de la Organización Mundial declaró ante la comunidad internacional que nos encontramos ante un escenario de pandemia, caracterizada por una neumonía de etiología desconocida que apareció en Wuhan-China a finales de 2019, (Cheng, V. C. C, et al., 2020, Citado citado por Koury y Hirschhaut, 2020) por tanto, estamos frente a la emergencia sanitaria más significativa del siglo XXI.
Esta situación hizo que nuestra mirada diera un giro, comenzáramos a cuestionar las esferas social y política tanto nacional como internacional, así como la económica. Por ello, esta edición presenta estudios realizados antes de la pandemia.
The content of adipokines in women with hypothyroidism and type 2 diabetes mellitus
Authors: Verbovoy A. F. , Lomonova T. V. 
Published: January 2021

Introduction. Type 2 diabetes mellitus (DM) and hypothyroidism are the most common endocrine pathologies. These diseases are associated with atherogenic dyslipidemia, insulin resistance, and overweight.Aim. Тo assess the relationship between adipokines and hormone-metabolic parameters in women with hypothyroidism, type 2 diabetes mellitus and their combination.Materials and methods. We examined 119 women aged 45 to 74 years: 42 women with primary hypothyroidism, 38 women with type 2 diabetes and 39 women with a combination of type 2 diabetes and hypothyroidism. All patients underwent an anthropometric examination, studied the indicators of lipid and carbohydrate metabolism, the content of adiponectin, leptin and resistin.Results. In women with type 2 diabetes and its combination with hypothyroidism, hyperglycemia, hyperinsulinemia, and insulin resistance were revealed. In all groups, an increase in total cholesterol, triglycerides, atherogenic coefficient was found. The examined women with a combination of hypothyroidism and type 2 diabetes mellitus had a decreased level of adiponectin and an increased level of leptin. In patients with hypothyroidism and patients with type 2 diabetes, a decrease in adiponectin levels and an increase in leptin and resistin were revealed.Discussion. The most pronounced hyperinsulinemia and insulin resistance were found in the group of patients with a combination of hypothyroidism and type 2 diabetes. At the same time, the combination of type 2 diabetes and hypothyroidism in the examined women, according to our data, did not aggravate lipid metabolism disorders. Against the background of visceral obesity in women with a combination of diseases, hypoadiponectinemia and hyperleptinemia were most pronounced. In this group, the level of resistin was positively correlated with the level of insulin and the index of insulin resistance.Conclusion. In women with hypothyroidism, type 2 diabetes and their combination, atherogenic dyslipidemia, hyperleptinemia, and hypoadiponectinemia were established. Hypoadiponectinemia and hyperleptinemia are involved in the development of atherogenic dyslipidemia in women with primary hypothyroidism.