bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misunderstanding, Misperception and Mistakes: The Logic of the Grail in Old French Arthurian Romance and Thomas Malory’s Tale of the Sankgreal
Authors: Baldon Martha Claire 
Published: September 2021

AbstractThis article seeks to resituate critical discussions about logic in the Old French Grail romances and Thomas Malory’sTale of the Sankgreal. Where previous scholarship has emphasised the mystical elements of the Old French Grail narratives to suggest alternate meanings for the Grail itself, this article reads the Grail miracles as structuring devices that reflect classical theories of dialectic and demonstrative argumentation. Through examining one example from Chrétien de Troyes’Perceval, the Didot-Perceval, The Vulgate CycleQueste del Saint Graal, and Thomas Malory’sTale of the Sankgreal, this article also highlights fundamental similarities between the logical systems underlying each Grail narrative that are not restricted by language or date of composition. Thus, the article depicts Malory not just as consciously drawing upon the VulgateQueste del Saint Graal, but also as unconsciously inheriting elements from each of his Old French predecessors.
Differences between immunotherapy-induced and primary hypophysitis—a multicenter retrospective study
Authors: Amereller Felix , Deutschbein Timo , Joshi Mamta , Schopohl Jochen , Schilbach Katharina , Detomas Mario , Duffy Leo , Carroll Paul , Papa Sophie , Störmann Sylvère 
Published: September 2021

Abstract
Objective
Immune checkpoint inhibitors can cause various immune-related adverse events including secondary hypophysitis. We compared clinical characteristics of immunotherapy-induced hypophysitis (IIH) and primary hypophysitis (PH)

Design
Retrospective multicenter cohort study including 56 patients with IIH and 60 patients with PH.

Methods
All patients underwent extensive endocrine testing. Data on age, gender, symptoms, endocrine dysfunction, MRI, immunotherapeutic agents and autoimmune diseases were collected.

Results
Median time of follow-up was 18 months in IIH and 69 months in PH. The median time from initiation of immunotherapy to IIH diagnosis was 3 months. IIH affected males more frequently than PH (p < 0.001) and led to more impaired pituitary axes in males (p < 0.001). The distribution of deficient adenohypophysial axes was comparable between both entities, however, central hypocortisolism was more frequent (p < 0.001) and diabetes insipidus considerably less frequent in IIH (p < 0.001). Symptoms were similar except that visual impairment occurred more rarely in IIH (p < 0.001). 20 % of IIH patients reported no symptoms at all. Regarding MRI, pituitary stalk thickening was less frequent in IIH (p = 0.009). Concomitant autoimmune diseases were more prevalent in PH patients before the diagnosis of hypophysitis (p = 0.003) and more frequent in IIH during follow-up (p = 0.002).

Conclusions
Clinically, IIH and PH present with similar symptoms. Diabetes insipidus very rarely occurs in IIH. Central hypocortisolism, in contrast, is a typical feature of IIH. Preexisting autoimmunity seems not to be indicative of developing IIH.
Garden optimization problems for benchmarking quantum annealers
Authors: Gonzalez Calaza Carlos D. , Willsch Dennis , Michielsen Kristel 
Published: September 2021

AbstractWe benchmark the 5000+ qubit system coupled with the Hybrid Solver Service 2 released by D-Wave Systems Inc. in September 2020 by using a new class of optimization problems calledgarden optimization problemsknown in companion planting. These problems are scalable to an arbitrarily large number of variables and intuitively find application in real-world scenarios. We derive their QUBO formulation and illustrate their relation to the quadratic assignment problem. We demonstrate that the system and the new hybrid solver can solve larger problems in less time than their predecessors. However, we also show that the solvers based on the 2000+ qubit system sometimes produce more favourable results if they can solve the problems.
Psychometric validation of the EORTC QLQ-HCC18 in patients with previously treated unresectable hepatocellular carcinoma
Authors: Serrano Daniel , Podger Lauren , Barnes Gisoo , Song James , Tang Boxiong 
Published: September 2021

AbstractTo demonstrate the measurement properties of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Hepatocellular Carcinoma 18-question module (EORTC QLQ-HCC18) within a previously treated, unresectable hepatocellular carcinoma (HCC) clinical trial population that was distinct from the published QLQ-HCC18 validation population. Analyses were conducted using data from BGB-A317-208, an open label, international, clinical trial assessing efficacy and safety of the monoclonal antibody tislelizumab in adult HCC patients. The EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and QLQ-HCC18 instruments were assessed at baseline and weeks 3 and 9 follow-up visits. Per US Food and Drug Administration guidance, psychometric validation of the QLQ-HCC18 included reliability (internal consistency and test–retest), construct validity (convergent and discriminant validity and known-groups validity), ability to detect change, and meaningful within-patient change (MWPC). Known-groups validity and MWPC analyses were also stratified on several pre-defined subgroups. A total of 248 patients were included. Only the QLQ-HCC18 fatigue, nutrition, and index domains demonstrated acceptable internal consistency; acceptable test–retest reliability was found for fatigue, body image, nutrition, pain, sexual interest, and index domains. The QLQ-HCC18 fatigue domain achieved the pre-specified criterion defining acceptable convergent and discriminant validity for 13 of 16 correlations, whereas the index domain achieved the pre-specified criterion for 14 of 16 correlations. Clear differentiation of the QLQ-HCC18 change scores between improvement and maintenance anchor groups were observed for body image, fatigue, pain, and index domains, whereas differentiation between deterioration and maintenance anchor groups were observed for fever and fatigue domains. MWPC point estimates defining improvement for the QLQ-HCC18 fatigue and index domains were −7.18 and −4.07, respectively; MWPC point estimates defining deterioration were 5.34 and 3.16, respectively. The EORTC QLQ-HCC18 fatigue and index domains consistently demonstrated robust psychometric properties, supporting the use of these domains as suitable patient-reported endpoints within a previously treated, unresectable HCC patient population.
Publication outperformance among global South researchers: An analysis of individual-level and publication-level predictors of positive deviance
Authors: Albanna Basma , Handl Julia , Heeks Richard 
Published: September 2021

AbstractResearch and development are central to economic growth, and a key challenge for countries of the global South is that their research performance lags behind that of the global North. Yet, among Southern researchers, a few significantly outperform their peers and can be styled research “positive deviants” (PDs). In this paper we ask: who are those PDs, what are their characteristics and how are they able to overcome some of the challenges facing researchers in the global South? We examined a sample of 203 information systems researchers in Egypt who were classified into PDs and non-PDs (NPDs) through an analysis of their publication and citation data. Based on six citation metrics, we were able to identify and group 26 PDs. We then analysed their attributes, attitudes, practices, and publications using a mixed-methods approach involving interviews, a survey and analysis of publication-related datasets. Two predictive models were developed using partial least squares regression; the first predicted if a researcher is a PD or not using individual-level predictors and the second predicted if a paper is a paper of a PD or not using publication-level predictors. PDs represented 13% of the researchers but produced about half of all publications, and had almost double the citations of the overall NPD group. At the individual level, there were significant differences between both groups with regard to research collaborations, capacity development, and research directions. At the publication level, there were differences relating to the topics pursued, publication outlets targeted, and paper features such as length of abstract and number of authors.
Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles
Authors: Blaauwendraad Sophia M. , Voerman Ellis , Trasande Leonardo , Kannan Kurunthachalam , Santos Susana , Ruijter George J. G. , Sol Chalana M. , Marchioro Linda , Shokry Engy , Koletzko Berthold , Jaddoe Vincent W. V. , Gaillard Romy 
Published: September 2021

Abstract
Background
Fetal exposure to bisphenols is associated with altered fetal growth, adverse birth outcomes and childhood cardio-metabolic risk factors. Metabolomics may serve as a tool to identify the mechanisms underlying these associations. We examined the associations of maternal bisphenol urinary concentrations in pregnancy with neonatal metabolite profiles from cord blood.

Methods
In a population-based prospective cohort study among 225 mother–child pairs, maternal urinary bisphenol A, S and F concentrations in first, second and third trimester were measured. LC–MS/MS was used to determine neonatal concentrations of amino acids, non-esterified fatty acids (NEFA), phospholipids (PL), and carnitines in cord blood.

Results
No associations of maternal total bisphenol concentrations with neonatal metabolite profiles were present. Higher maternal average BPA concentrations were associated with higher neonatal mono-unsaturated alkyl-lysophosphatidylcholine concentrations, whereas higher maternal average BPS was associated with lower neonatal overall and saturated alkyl-lysophosphatidylcholine (p-values < 0.05).Trimester-specific analyses showed that higher maternal BPA, BPS and BPF were associated with alterations in neonatal NEFA, diacyl-phosphatidylcholines, acyl-alkyl-phosphatidylcholines, alkyl-lysophosphatidylcholine, sphingomyelines and acyl-carnitines, with the strongest effects for third trimester maternal bisphenol and neonatal diacyl-phosphatidylcholine, sphingomyeline and acyl-carnitine metabolites (p-values < 0.05). Associations were not explained by maternal socio-demographic and lifestyle characteristics or birth characteristics.

Discussion
Higher maternal bisphenol A, F and S concentrations in pregnancy are associated with alterations in neonatal metabolite profile, mainly in NEFA, PL and carnitines concentrations. These findings provide novel insight into potential mechanisms underlying associations of maternal bisphenol exposure during pregnancy with adverse offspring outcomes but need to be replicated among larger, diverse populations.
Effect of environmental stressors on the mRNA expression of ecdysone cascade genes in Chironomus riparius
Authors: de la Fuente Mercedes , Folgar Raquel Martín , Martínez-Paz Pedro , Cortés Estrella , Martínez-Guitarte José Luis , Morales Mónica 
Published: September 2021

Abstract
Chemical compounds produced by humans are continuously reaching the environment. In this work, we characterised the expression patterns of important endocrine-related genes involved in the ecdysone pathway in the fourth larval instar of the model species Chironomus riparius after exposure to three chemicals: ethinyl oestradiol (EE), nonylphenol (NP) and bis(tributyltin) oxide (TBTO). We used real-time PCR to analyse the gene expression levels of ecdysone receptor (EcR) and ultraspiracle (usp), two genes that encode the dimerising partners of the functional ecdysone receptor; the orphan receptor ERR (oestrogen-related receptor), with an unknown function in invertebrates; and E74, an early response gene induced by ecdysteroids. We estimated the bioaccumulation potential, bioavailability and physicochemical properties of these chemicals, together with a number of other exogenous agents known to interfere with the hormonal system. We also provide a review of previous transcriptional studies showing the effect of all these chemicals on ecdysone cascade genes. This analysis provides useful data for future ecotoxicological studies involving invertebrate species.

Capsule
Changes in transcriptional activities of EcR, E74, usp and ERR genes after exposure to endocrine-disrupting chemicals would be useful as molecular bioindicators of endocrine disruption in Chironomus riparius.
Development of a redundant anthropomorphic hydraulically actuated manipulator with a roll-pitch-yaw spherical wrist
Authors: Cheng Min , Han Zenan , Ding Ruqi , Zhang Junhui , Xu Bing 
Published: September 2021

AbstractThe demand for redundant hydraulic manipulators that can implement complex heavy-duty tasks in unstructured areas is increasing; however, current manipulator layouts that remarkably differ from human arms make intuitive kinematic operation challenging to achieve. This study proposes a seven-degree-of-freedom (7-DOF) redundant anthropomorphic hydraulically actuated manipulator with a novel roll-pitch-yaw spherical wrist. A hybrid series-parallel mechanism is presented to achieve the spherical wrist design, which consists of two parallel linear hydraulic cylinders to drive the yaw/pitch 2-DOF wrist plate connected serially to the roll structure. Designed as a 1RPRRR-1SPU mechanism (“R”, “P”, “S”, and “U” denote revolute, prismatic, spherical, and universal joints, respectively; the underlined letter indicates the active joint), the 2-DOF parallel structure is partially decoupled to obtain simple forward/inverse kinematic solutions in which a closed-loop subchain “RPRR” is included. The 7-DOF manipulator is then designed, and its third joint axis goes through the spherical center to obtain closed-form inverse kinematic computation. The analytical inverse kinematic solution is drawn by constructing self-motion manifolds. Finally, a physical prototype is developed, and the kinematic analysis is validated via numerical simulation and test results.
Global Mental Health Research: Time to Integrate Basic Science
Authors: Meffert Susan M. 
Published: September 2021

AbstractThe Lancet Commission on Global Mental Health recommends the inclusion of research on the biological underpinnings of mental disorders as part of efforts to reduce the global burden of mental disorders. The search for defining features of mental disorders in non-Euro American settings is historically charged for the field. Yet, as illustrated by analysis of the NIMH objectives, the biological study of mental disorders cannot be scientifically sound without better inclusion of under-represented, globally diverse populations. It is time for global mental health researchers to take up the challenge and advance impactful research across the full translational spectrum.
Psychometric Properties of the Fear of COVID-19 Scale: a Response to Mercado-Lara et al. “Validity and Reliability of the Spanish Version of Fear of COVID-19 Scale in Colombian Physicians”
Authors: Lin Chung-Ying , Griffiths Mark D. , Pakpour Amir H. 
Published: September 2021

AbstractA paper reporting the psychometric properties of the Spanish Fear of COVID-19 Scale (FCV-19S) among Colombian physicians was recently published in the International Journal of Mental Health and Addiction. Although we welcome the translation and validation of our seven-item scale, this commentary outlines some major concerns we have with the study especially the removal of two items in developing a five-item FCV-19S. Based on these concerns, we strongly recommend that healthcare providers and researchers should use the five-item FCV-19S with caution.
A comparison of intra-operative diagnosis to histopathological diagnosis of acute appendicitis in paediatric and adult cohorts: an analysis of over 1000 patients
Authors: Harris Johnathon , Fleming Christina A. , Stassen Paul N. , Mullen Daniel , Mohan Helen , Foley James , Heeney Anna , Nugent Emmeline , Schmidt Karl , Mealy Ken 
Published: September 2021

Abstract
Background
Appendicitis is a common general surgical emergency. The role of removing a normal appendix is debated. However, this relies on accurate intra-operative diagnosis of a normal appendix by the operating surgeon. This study aimed to compare surgeon’s intra-operative assessment to final histological result acute appendicitis in paediatric and adult patients.

Methods
All patients who underwent appendicectomy over a 14-year period in a general surgical department were identified using the prospective Lothian Surgical Audit system and pathology reports retrieved to identify final histological diagnosis. Open appendicectomy was selected to examine, as the routine practise at our institution is to remove a normal appendix at open appendicectomy.

Results
A total of 1035 open appendicectomies were performed for clinically suspected appendicitis. Sensitivity of intra-operative diagnosis of appendicitis with operating surgeon was high at 95.13% with no difference between trainee and consultant surgeon or between adult and paediatric cases. Specificity of intra-operative diagnosis was lower in the paediatric group (32.58%) than in the adult group (40.58%). Women had a higher rate of negative appendicectomy than men.

Conclusion
The results of this study highlight some discordance between histological evidence of acute appendicitis and intra-operative impression. Therefore other clinical variables and not just macroscopic appearance alone should be used when deciding to perform appendicectomy.
Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial
Authors: Hergenroeder Georgene W. , Yokobori Shoji , Choi Huimahn Alex , Schmitt Karl , Detry Michelle A. , Schmitt Lisa H. , McGlothlin Anna , Puccio Ava M. , Jagid Jonathan , Kuroda Yasuhiro , Nakamura Yukihiko , Suehiro Eiichi , Ahmad Faiz , Viele Kert , Wilde Elisabeth A. , McCauley Stephen R. , Kitagawa Ryan S. , Temkin Nancy R. , Timmons Shelly D. , Diringer Michael N. , Dash Pramod K. , Bullock Ross , Okonkwo David O. , Berry Donald A. , Kim Dong H. 
Published: September 2021

Abstract
Background
Hypothermia is neuroprotective in some ischemia–reperfusion injuries. Ischemia–reperfusion injury may occur with traumatic subdural hematoma (SDH). This study aimed to determine whether early induction and maintenance of hypothermia in patients with acute SDH would lead to decreased ischemia–reperfusion injury and improve global neurologic outcome.

Methods
This international, multicenter randomized controlled trial enrolled adult patients with SDH requiring evacuation of hematoma within 6 h of injury. The intervention was controlled temperature management of hypothermia to 35 °C prior to dura opening followed by 33 °C for 48 h compared with normothermia (37 °C). Investigators randomly assigned patients at a 1:1 ratio between hypothermia and normothermia. Blinded evaluators assessed outcome using a 6-month Glasgow Outcome Scale Extended score. Investigators measured circulating glial fibrillary acidic protein and ubiquitin C-terminal hydrolase L1 levels.

Results
Independent statisticians performed an interim analysis of 31 patients to assess the predictive probability of success and the Data and Safety Monitoring Board recommended the early termination of the study because of futility. Thirty-two patients, 16 per arm, were analyzed. Favorable 6-month Glasgow Outcome Scale Extended outcomes were not statistically significantly different between hypothermia vs. normothermia groups (6 of 16, 38% vs. 4 of 16, 25%; odds ratio 1.8 [95% confidence interval 0.39 to ∞], p = .35). Plasma levels of glial fibrillary acidic protein (p = .036), but not ubiquitin C-terminal hydrolase L1 (p = .26), were lower in the patients with favorable outcome compared with those with unfavorable outcome, but differences were not identified by temperature group. Adverse events were similar between groups.

Conclusions
This trial of hypothermia after acute SDH evacuation was terminated because of a low predictive probability of meeting the study objectives. There was no statistically significant difference in functional outcome identified between temperature groups.
Belief-biased representations of textual information in bilinguals: Language as a source characteristic
Authors: Karimi Mohammad N. , Richter Tobias 
Published: September 2021

AbstractWhen pursuing a controversial socio-scientific issue, readers are expected to construct balanced representations that include overlapping and opposing information. However, readers’ mental representations are often biased towards their prior beliefs. Previous research on such text-belief consistency effects have been conducted mostly in monolingual contexts. The present study investigated whether document language, as a source characteristic, moderates text-belief consistency effects at the situation-model and text-base representation levels. Eighty-seven bilingual readers—selected from a larger initial sample—read two documents on the global spread of English. The documents were either presented in participants’ first (Persian) and second (English) languages, or one was presented in Persian and the other one in English. A recognition task was used to assess situation-model strength and text-base strength. Overall, participants built stronger situation models for the belief-consistent information as opposed to belief-inconsistent information. However, document language moderated the text-belief consistency effect. When both texts were presented in English, the text-belief consistency effect was smaller than when both texts were presented in Persian. For the combination of English and Persian texts, the text-belief consistency effect was enlarged when the belief-consistent text was presented in English and the belief-inconsistent text in Persian but disappeared when the text-belief consistent text was presented in Persian and the belief-inconsistent text in English. These results suggest that document language can serve as a strong credibility cue that can eliminate belief effects, at least when the document language and the controversial issue are inherently related.
Evaluation of a streamlined sentinel lymph-node imaging protocol in early-stage oral cancer
Authors: Zeeuw Michiel , Mahieu Rutger , de Keizer Bart , de Bree Remco 
Published: September 2021

AbstractObjectiveSentinel lymph-node (SLN) mapping for early-stage oral squamous cell carcinoma (OSCC) is comprehensive and consequently time-consuming and costly. This study evaluated the clinical value of several SLN imaging components and analyzed the accuracy for SLN identification using a streamlined SLN imaging protocol in early-stage OSCC.Materials and methodsThis retrospective within-patient evaluation study compared both number and localization of identified SLNs between the conventional SLN imaging protocol and a streamlined imaging protocol (dynamic lymphoscintigraphy (LSG) for 10 min directly post-injection and SPECT-CT at ~ 2 h post-injection). LSG and SPECT-CT images of 77 early-stage OSCC patients, scheduled for SLN biopsy, were evaluated by three observers. Identified SLNs using either protocol were related to histopathological assessment of harvested SLNs, complementary neck dissection specimens and follow-up status.ResultsA total of 200 SLNs were identified using the streamlined protocol, and 12 additional SLNs (n = 212) were identified with the conventional protocol in 10 patients. Of those, 9/12 were identified on early static LSG and 3/12 on late static LSG. None of the additionally identified SLNs contained metastases; none of those in whom additional SLNs were identified developed regional recurrence during follow-up. Only inferior alveolar process carcinoma showed a higher rate of additionally identified SLNs with the conventional protocol (p = 0.006).ConclusionEarly dynamic LSG can be reduced to 10 min. Late static LSG may be omitted, except in those with a history of oncological neck treatment or with OSCC featuring slow lymphatic drainage. Early static LSG appeared to be contributory in most OSCC subsites.