bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Conventional NSAIDs: Transdermal Efficacy and Therapeutic Potential of Nepafenac in Comparison to Diclofenac Sodium
Authors: LaStella Alexandra 
Published: December 2024

Oral non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a multitude of treatment-limiting contraindications, conflicting comorbidities, drug-drug interactions, and bothersome systemic effects. Contrary to the widespread use and well-established efficacy of systemic NSAIDs, locally-acting NSAIDs are still an area of ongoing pharmacologic investigation. As of December 2024, diclofenac sodium 1% topical gel is the only FDA-approved cutaneous NSAID, despite the availability of other structurally similar NSAIDs with comparable potencies, physicochemical properties, and pharmacokinetics. Nepafenac, a relatively new ophthalmic NSAID, has certain unique attributes which make it a promising candidate for transdermal formulations. Having undergone an expansive review of the available literature, we identify pharmacodynamic, pharmacokinetic, and physicochemical similarities between diclofenac and nepafenac. Our results infer that transdermal nepafenac possesses superior therapeutic efficacy vs diclofenac in the management of localized pain and inflammation. Given its unique pharmacodynamic attributes and enhanced efficacy profile, transdermal nepafenac shows great promise as a viable option for localized pain and inflammation. Moving ahead, further formulary and clinical efficacy studies are needed to fully assess its potential in a transdermal application.
Association de variables fonctionnelles avec les fonctions discursives du <i>hedged performative</i> : une étude sur corpus du discours parlementaire britannique
Authors: Latouche Lucie 
Published: December 2024

Context: Hedged performatives (HPs), first discussed by Fraser (1975), result from the combination of a (semi-)modal and a performative verb (I have to say, I must confess, I can tell,…). Even though they are often mentioned in the literature, the lack of empirical studies into the phenomenon is apparent on both the quantitative and the qualitative side. Indeed, their frequency of use in English and its varieties has never been analysed, nor has the way they function in context. Objectives : To examine the co(n)textual parameters that determine the function and use of hedging particles in British parliamentary discourse from the Hansard corpus. Methodology: Five co(n)textual parameters were examined and explained to have a role in the function and the use of the prototypical HPs I must x, I have to x, and I can x. HPs’ two main functions, downtoner and emphasizer, are investigated. As explained by Holmes (1984), to hedge and to emphasize the illocutionary force of an utterance are two complementary strategies that can be expressed by the same linguistic element; and HPs are one of them. The approach taken in this article thus differs from, for example, Lakoff’s (1972) approach, which is mainly focused on the impact of the modal on the performative verb, while the present study analyzes the construction and its functions in context. Results: Both functions can emanate from the combination of co(n)textual parameters, especially the thematic orientation of the proposition on which the HP has scope (speaker, addressee, third person, situation), and the semantic valency of that proposition (positive, negative, neutral) (Depraetere et Kaltenböck, 2023). We also find that about 9% of uses fall somewhere between these two functions. Finally, we show, that HPs have an important role to play in facework (Brown et Levinson, 1987), either by threatening the speaker’s or the addressee’s face, or by preserving it. Conclusions : This explanatory study will be expanded upon in my doctoral thesis, in which the two main functions of HPs —downtoner and emphasizer— will be investigated. The additional discourse marker use of HPs will also be examined in more detail.
Effect of Sun-dried Tomato Powder as an add on therapy on Glycemic Profile, Renal Function and Liver Function in an individual with type 2 diabetes mellitus (T2DM): A Case Report
Authors: Ahmed Altaf , Shetty Prashanth , Shetty Geetha B , Girishankara Moodala 
Published: December 2024

Type 2 Diabetes mellitus (T2DM) is common metabolic disease, which is characterized by the presence of hyperglycemia. A 38-year-old male patient presented with hyperglycemia and a history of K/C/O type 2 diabetes mellitus (T2DM) dating back four years. It was suggested that he take the anti-diabetic medication Tab Metformin 500mg twice daily, after meals. Even after using anti-diabetic medications, the patient's blood sugar levels remained uncontrolled. He visited to integrated holistic center OPD department for further management. After taking complete case history, he was advised to take 15 gm. of sundried tomato powder every day morning in 150 ml of water in empty stomach for the period of 60 days along with regular his medication. The study reveals that, the improvement seen in Fasting blood sugar (134-111 mm/dl), Post-prandial Blood sugar (171 – 148 mm/dl), HbA1c (7.1 – 6.9 %) and the base line renal and liver profile were normal and taken data in 5 time points. The Renal and Liver profile was within normal limit through out the study. The case report shows that, the sundried tomato powder helps in improving Glycemic profile and maintains Renal and liver function among patient with T2DM. The larger robust randomized controlled trial is needed to conclude the efficacy of sundried tomato powder as a safe and affordable intervention in clinical practice.
Polio: Post-Campaign CommunicationAssessment in Banadir Region, Somalia
Authors: Sharif Shafie , Yusuf Farah , Gedi Mohamed , Mahamed Mahmoud 
Published: December 2024

Polio campaigns are routinely conducted in Somalia and the ministry of health engages radios, TVs, mounted car announcements, and community mobilizers.Purpose: The assignment was initiated in order to assess the effectiveness of polio mass media campaigns with respect to outreach to targeted audiences and understanding of the messages of the various media, channels, and contents.Design/methodology: A quantitative method has been used for the data collection; The study heavily relies on primary data collection from the field. Visited houses were randomly selected in targeted districts.Findings The findings of this study indicate that, 7 out of 10 people surveyed cited that mass media as their source of information about polio campaigns. Also the study found Misconceptions, misinformation, fear as well as intricate tribal and cultural norms are challenges facing polio campaign in Benadir region.Research limitations/implications. This study only emphasized Benadir region polio cmapaign; thus, the findings of the present study may not be applicable to other countries.Originality/value: Limited studies have been conducted to investigate the impact of Polio post-campaign communication in Benadir region Somalia
Dossiê: Conhecimento e autonomia docente no campo do ensino das Áreas Curriculares
Authors: Locatelli Arinalda Silva , Paula Andrey Patrick Monteiro de , Gracioli Jéferson Muniz Alves 
Published: December 2024

No trecho acima, Madalena Freire Weffort (1996) nos apresenta algumas características do sujeito construtor do conhecimento, sujeito esse que se forma num misto de sentimentos e com base na adoção de um olhar pensante. Todavia, a autora nos indica que nem todos têm o domínio desse construto, ou seja,alguns são alijados do seu desejo, do seu fazer e de seu pensamento. Dessa constatação, duas palavras se tornam caras ao trabalho docente, são elas: conhecimento e autonomia, termos que se tornaram eixos da temática da VI edição da Exposição de Metodologias, Alternativas e Tecnologias para o Ensino das Ciências (EXPOMATEC), organizada pelo Curso de Pedagogia do Centro de Educação Humanidades e Saúde (CEHS) da Universidade Federal do Norte do Tocantins (UFNT) e que agora origina o Dossiê: Conhecimento e Autonomia Docente no campo do ensino das áreas curriculares.
O presente Dossiê configura-se a partilha de estudos, experiências, reflexões, análises, aprendizados e aprendizagens (De Paula, 2023) de docentes e discentes de ensino superior e da educação básica de diferentes localidades e regiões do Brasil, problematizando os múltiplos sentidos de ensinar as ciências na educação básica.
Trata-se de um compêndio de vinte e quatro artigos, selecionados a partir das comunicações orais e relatos de experiência apresentados na VI Expom@tec. As temáticas abordadas formam um mosaico discursivo envolvendo questões sobre educação ambiental; educação-cartográfica; aspectos do ensino sobre astrologia e astronomia; história, educação, materiais e saberes na cultura Apinajé; as contribuições, desafios e potencialidades do Programa Residência Pedagógica e de Projetos Universitários como o Ciclo de Leitura e o GeminAR-te que incidem sobre a formação inicial e continuada de docentes da educação básica; as perspectivas teórico metodológicas no ensino de ciência e tecnologias digitais; a formação do leitor de aluno com deficiência visual; o ensino por investigação como promotor do letramento científico; a construção de brinquedos recicláveis para utilização no curso de Educação Física; a compreensão pedagógica de utilização do Programa Dinheiro Direto na Escola (PDDE); e aspectos reflexivos sobre a ditadura civil-militar brasileira e história e memória da educação.
Os artigos que integram o presente dossiê, tem a construção do conhecimento do ensino das diversas áreas curriculares em sua diversidade teórico-metodológica como foco das discussões apresentadas, primando, pelo fortalecimento e consolidação da perspectiva de autonomia docente, ou seja, a garantia da existência do sujeito docente que deseja, pensa, problematiza e concretiza seu fazer pedagógico.
Uma análise das contribuições da disciplina de Psicologia da Educação para a formação inicial de professores de matemática
Authors: Corso Mikulski Sthefany , Cardoso Brito Claudenice 
Published: December 2024

A psicologia como ciência auxiliar da educação contribui para organizar o ensino, avaliar o processo de desenvolvimento e aprendizagem dos estudantes. Neste aspecto, discutimos sobre a importância da Psicologia da Educação para a formação inicial de professores de Matemática. Adotamos a pesquisa participativa para analisarmos um grupo de estudantes do curso de licenciatura em Matemática e a forma como eles se apropriam dos conhecimentos e desenvolvem a atividade de estudo. Para isso utilizamos os conceitos de coletividade, autonomia e autorregulação da Teoria Histórico-Cultural. Os resultados iniciais apontam para o desenvolvimento da autonomia, que reverbera no trabalho coletivo.
Palavras-chave: formação inicial de professores, teoria histórico-cultural, trabalho coletivo.

An analysis of the contributions of the Educational Psychology discipline to the initial training of mathematics teachers
ABSTRACT. Psychology as an auxiliary science of education contributes to organizing teaching and evaluating the development and learning process of students. In this aspect, we discuss the importance of Educational Psychology for the initial training of Mathematics teachers. We adopted participatory research to analyze a group of students from the Mathematics degree course and the way they acquire knowledge and develop their study activity. For this we use the concepts of collectivity, autonomy, self-regulation from Historical-Cultural Theory. The initial results point to the development of autonomy, which reverberates in collective work.
Keywords: initial teacher training, historical-cultural theory, collective work.

Un análisis de los aportes de la disciplina Psicología de la Educación a la formación inicial de profesores de matemáticas
RESUMEN. La psicología como ciencia auxiliar de la educación contribuye a organizar la enseñanza y evaluar el proceso de desarrollo y aprendizaje de los estudiantes. En este aspecto, se discute la importancia de la Psicopedagogía para la formación inicial del profesorado de Matemáticas. Adoptamos una investigación participativa para analizar un grupo de estudiantes de la carrera de Matemáticas y la forma en que adquieren conocimientos y desarrollan su actividad de estudio. Para ello utilizamos los conceptos de colectividad, autonomía, autorregulación de la Teoría Histórico-Cultural. Los primeros resultados apuntan al desarrollo de la autonomía, que repercute en el trabajo colectivo.
Palabras clave: formación inicial docente, teoría histórico-cultural, trabajo colectivo
ສຶກສາການປະຕິບັດ 5 ຫຼັກມູນການສຶກສາ ກໍລະນີສຶກສາ: ຢູ່ໂຮງຮຽນມັດທະຍົມສົມບູນ ປ່ອງຄໍາ ນະຄອນຫຼວງພະບາງ ແຂວງຫຼວງພະບາງ ສົກສຶກສາ 2022-2023
Authors: ສິລິລັດ ຄຳພີ , ເລຍມາເຮີ ເຢຍເຮີ , ອຸດົມສິດ ຫຸມເພັງ , ສຸລິວົງ ເພັດສະໝອນ , ແກ້ວປະເສີດ ດາລີວອນ , ອູ່ຄໍາຫຼ້າ ຈາຍ , ຄົດໄຊໂຍ ໄຊພອນ 
Published: December 2024

ການຄົ້ນຄວ້າຄັ້ງນີ້ມີຈຸດປະສົງເພື່ອສຶກສາການປະຕິບັດ 5 ຫຼັກມູນການສຶກສາ ໂຮງຮຽນ ມັດທະຍົມສົມບູນ ປ່ອງຄໍາ ນະຄອນຫຼວງພະບາງ ແຂວງຫຼວງພະບາງ ສົກສຶກສາ 2022-2023, ໂດຍເປັນການສຶກສາແບບສຳຫຼວດ ນັກຮຽນຊັ້ນມັດທະຍົມຕອນປາຍ ທີ່ເປັນກຸ່ມຕົວຢ່າງ ຈຳນວນ 127 ຄົນ, ຍິງ 71 ຄົນຈາກຈຳນວນນັກຮຽນທັງໝົດຈຳນວນ 421 ຄົນ, ຍິງ 234 ຄົນ. ດ້ວຍວິທີການເລືອກກຸ່ມຕົວຢ່າງແບບ ສຸ່ມປະຊາກອນ 30% ອີງໃສ່ ( ເກນ 15-30% ຂອງທ່ານບຸນຊົມ ສີສະອາດ ), ເຄື່ອງມືທີ່ນໍາມາສຶກສາໃນຄັ້ງນີ້ ໄດ້ແກ່ແບບສອບຖາມຂໍ້ມູນກ່ຽວກັບການປະຕິບັດ 5 ຫຼັກມູນການສຶກສາ ກໍລະນີສຶກສາ: ຢູ່ໂຮງຮຽນມັດທະຍົມສົມບູນ ປ່ອງຄໍາ ນະຄອນຫຼວງພະບາງ ແຂວງຫຼວງພະບາງ ສົກສຶກສາ 2022-2023. ເຊິ່ງປະກອບມີ 5 ດ້ານ ທີ່ເປັນປັດໄຈຫຼັກ ໄດ້ແກ່: ດາ້ນຄຸນສົມບັດສຶກສາ, ດາ້ນປັນຍາສຶກສາ, ດາ້ນແຮງງານສຶກສາ, ດາ້ນພາລະສຶກສາ, ດາ້ນສິລະປະສຶກສາ. ການວິເຄາະຂໍ້ມູນແມ່ນນຳໃຊ້ຊອບແວຣ໌ສຳເລັດຮູບ ໂດຍການນາໍ ໃຊ້ໂປຣແກຣມ SPSS.V.21ເພື່ອວິເຄາະຫາຄ່າສະເລ່ຍ () ແລະ ຄ່າຜັນປ່ຽນມາດຕະຖານ ()
ຜົນການຄົ້ນຄວ້າພົບວ່າ ການປະຕິບັດ 5 ຫຼັກມູນການສຶກສາ ກໍລະນີສຶກສາ: ຢູ່ໂຮງຮຽນມັດທະຍົມສົມບູນ ປ່ອງຄໍາ ນະຄອນຫຼວງພະບາງ ແຂວງຫຼວງພະບາງ ສົກສຶກສາ 2022-2023 ແມ່ນຢູ່ໃນລະດັບປານກາງ ມີຄ່າສະເລ່ຍ = 3,19 ແລະ = 0,84 ເຊິ່ງສະແດງອອກໃນແຕ່ລະດ້ານດັ່ງນີ້:

ດ້ານນຄຸນສົມບັດສຶກສາ ແມ່ນການປະຕິບັດຢູ່ໃນລະດັບຫຼາຍ ທີ່ = 3,67 ແລະ = 0,96
ດ້ານປັນຍາສຶກສາ ແມ່ນການປະຕິບັດຢູ່ໃນລະດັບປານກາງ ທີ່ = 3,18 ແລະ = 0,91
ດ້ານນແຮງງານສຶກສາ ແມ່ນການປະຕິບັດຢູ່ໃນລະດັບປານກາງ ທີ່ = 3,18 ແລະ = 1,01
ດ້ານພາລະສຶກສາ ແມ່ນການປະຕິບັດຢູ່ໃນລະດັບປານກາງທີ່ = 2,83 ແລະ =0,91
ດ້ານສິລະປະສຶກສາ ແມ່ນການປະຕິບັດຢູ່ໃນລະດັບປານກາງ = 3,10 ແລະ =1,05

ຄໍາສັບສໍາຄັນ: 5 ຫຼັກມູນການສຶກສາ , ການປະຕິບັດ, ການຄຸ້ມຄອງ.
Reseña de Otfried Höffe: Der Weltbürger aus Königsberg. Immanuel Kant heute. Person und Werk
Authors: Leyva Gustavo 
Published: December 2024

Reseña de Der Weltbbürger aus Köngisberg. Immanuel Kant heute. Person und Werk de Otfried Höffe (Wiesbaden: S. Marix Verlag, 2024)
Research on the Location of Front-Loading Warehouses Based on the Reverse Logistics of Fresh Agricultural Products
Authors: XI Jiarui , GENG Nana 
Published: December 2024

The proposal to create front-loading warehouses has been suggested as a tactic to enhance the effectiveness and quality of distributing fresh agricultural products in the concluding stage of delivery. Nevertheless, there has been a noted escalation in the rate of loss of these products, which can be ascribed to multiple factors, including inaccuracies in demand forecasting. This incongruity arises from consumers’ inability to consume the initially forecasted quantities and unforeseen surges in demand from specific businesses. Consequently, surplus products are left unsold and eventually wasted. This study explores the viability of implementing a reverse logistics model for fresh agricultural products in tandem with the front-loading warehouse. The study presents both traditional and reverse dual models aimed at cost minimisation and introduces novel criteria for the selection of warehouse locations to enhance the efficiency of reverse logistics operations. An advanced hybrid heuristic optimisation algorithm is employed to identify optimal solutions, primarily focusing on minimising product loss rates, reducing logistics expenses and establishing a more equitable supply-demand equilibrium in the area. In the case of Nanjing, it is found that compared with the traditional model, because the network model assumes more functions, the front-loading warehouse in the reverse model has more site selection points in high-demand areas to meet the needs of consumers and is consistent with the distribution of population density and economic activities in Nanjing. At the same time, among the factors affecting the total cost, it is necessary to focus on transportation and fixed costs, while the impact of time and freight damage costs is less.
A multi-objective path optimization method for plant protection robots based on improved A*-IWOA
Authors: Niu Jing , Shen Chuanyan , Zhang Lipeng , Li Qijun , Ma Haohao 
Published: December 2024

Background
The widespread adoption of plant protection robots has brought intelligent technology and agricultural machinery into deep integration. However, with advances in robotic autonomy, the energy that robots can carry remains limited due to constraints on battery capacity and weight. This limitation restricts the robots’ ability to perform tasks continuously over extended periods.

Methods
To address the challenges of achieving low energy consumption and efficiency in path planning for plant protection robots operating in mountainous environments, a multi-objective path optimization approach was developed. This approach combines the improved A* algorithm with the Improved Whale Optimization Algorithm (A*-IWOA), utilizing a 2.5D elevation grid map. First, an energy consumption model was created to account for the robot’s energy use on slopes, based on its kinematic and dynamic models. Then, an improved A* search method was established by expanding to an 8-domain diagonal distance search and introducing a cost function influenced by cross-product decision values. Using the robot’s motion trajectory as a constraint, the IWOA algorithm was applied to optimize the vector cross-product factor (p) by dynamically adjusting population positions and inertia weights, to minimize both energy consumption and path curvature. Finally, in simulation and orchard scenarios, the application effects of the proposed algorithm were evaluated and compared against notable variants of the A* algorithm using the robot ROS 2 operating system.

Results
The experimental results show that the proposed algorithm substantially reduces the travel distance and enhances both path planning and computational efficiency. The improved approach meets the driving accuracy and energy consumption requirements for plant protection robots operating in mountainous environments.

Discussion
This algorithm offers significant advantages in terms of computational accuracy, convergence speed, and efficiency. Moreover, the resulting paths satisfy the stringent energy consumption and path planning requirements of robots in unstructured mountain terrain. This improved algorithm could also be replicated and applied to other fields, such as picking robots, factory inspection robots, and complex industrial environments, where robust and efficient path planning is required.
Synthesis and Characterization of Magnetic Graphene-Oxide
Authors: Rani Versha 
Published: December 2024

Magnetic graphene-oxide has recently taken in research spotlight due to its extraordinary physical and chemical properties. Here, we report the synthesis of Graphene oxide based magnetic nano-composites with the size of (~13-14 nm) using simple chemical co-precipitation method. The composites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample measurement (VSM). It was observed that all the composites are superparamagnetic in nature. The saturation magnetization was observed to increase with the increasing magnetite nanoparticles (MNPs) in the composites. The dielectric properties of the composites were also improved by adding MNPs. These results remark that synthesized nanocomposites have great potential for magnetic, capacitive, microwave absorption and bio medical applications such as drug delivery, tumor treatment etc.
Oral Biopharmaceutics and In vitro Pharmacokinetics of Commercially Available Pharmaceutical Formulations of Paracetamol: Implications in Paediatric Medicine
Authors: GO Ikeh , MN Nwafor , MN Ndubuisi , KO Okolo 
Published: December 2024

Aim: This study aimed to compare the oral pharmacokinetics of different paediatric paracetamol dosage forms that are commercially available in Nigeria.
Study Design: Experimental.
Place and Duration of Study: Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, between March and December 2023
Methodology: The study used the regular in vitro dialysis membrane method to predict the in vivo drug release of commercially available paracetamol syrups (n=5) and dispersible tablets (n=5) in the Nigerian market. The sink condition followed the Conventional USP dissolution method, using a dialysis membrane sac. The drug samples were studied in simulated salivary fluid of pH 7.4, simulated gastric fluid of pH 1.2, and simulated intestinal fluid of pH 6.5 over 8 hours to simulate their passage in the gastrointestinal tract. At predetermined time intervals, 5 ml of the dissolution medium was drawn out from the system, diluted appropriately and its absorbance measured against a suitable blank at λ = 250 nm using a UV/Vis Spectrophotometer, while a fresh volume of 5 ml of dissolution medium was introduced into the dissolution vessel after each withdrawal.
Results: Syrup dosage forms showed a faster drug release kinetics, based on their values. Kinetic parameters obtained from the linear regression analysis of the in vitro release resulted in a zero-order release kinetics, with for paracetamol paediatric syrups, and for tablets. Two-way ANOVA test of the AUC of dosage forms showed that the time required to elicit therapeutic response was extremely significant (F=44.37, DFn=3, DFd= 32 and P-value < 0.0001).
Conclusion: The comparative in vitro pharmacokinetic study of paracetamol dosage forms revealed that the paediatric syrup formula has a better release kinetics than the scaled down adult formula.
Co‐development of a risk assessment strategy for managed relocation
Authors: Karasov‐Olson Aviv , Schwartz Mark W. , Skikne Sarah A. , Hellmann Jessica J. , Olden Julian D. , Lawrence David J. , Morisette Jeffrey T. , Schuurman Gregor W. , Allen Sarah , Brigham Christy A. , Buttke Danielle , Miller‐Rushing Abraham J. , Trammell Melissa , Hawkins Hoffman Cat 
Published: August 2021

Abstract
Resource managers face mounting challenges when it comes to the implementation of climate change adaptation strategies. Novel adaptation strategies, such as managed relocation, frequently entail embracing substantial risk of unintended harm to the focal ecosystems, in an effort to alleviate serious threats to biological diversity (e.g. extinction). Assessing ecological risks associated with different adaptation strategies is consistently called for, but the process for doing so is often undefined.
Here, we describe a collaboration amongst university researchers, agency scientists and resource managers to create a set of ecological risk assessment protocols for managed relocation decision support. These protocols are designed to foster a rigorous assessment of ecological risk, while simultaneously being flexible and easy to use.
We describe a collaborative process through which we developed a structure for assessing risk that includes a suite of 17 risk categories aggregated into six overarching groups, which is placed within a broader decision context for managed relocation (e.g. evaluating feasibility, social acceptability). Our risk scoring includes both scaled estimates of risk and perceived confidence in those estimates.
Because of differences in the importance of risk categories, we do not recommend a quantitative summary across risk areas, but suggest decision makers make decisions based on three criteria: overall confidence that a proposed action can be confidently evaluated; low overall level or risk across categories; and no single risk category that is highly likely to result in severe adverse outcomes.