bluuebunny/crossref_metadata_2025_split huggingface dataset:
JAM-A interacts in cis with α3β1 integrin through CD151 to regulate collective cell migration of polarized epithelial cells
Authors: Thölmann Sonja , Seebach Jochen , Otani Tetsuhisa , Florin Luise , Schnittler Hans , Gerke Volker , Furuse Mikio , Ebnet Klaus 
Published: August 2021

Abstract
Junctional adhesion molecule (JAM)-A is a cell adhesion receptor localized at epithelial cellcell contacts with enrichment at the tight junctions. Its role during cell-cell contact formation and epithelial barrier formation has intensively been studied. In contrast, its role during collective cell migration is largely unexplored. Here we show that JAM-A regulates collective cell migration of polarized epithelial cells. Depletion of JAM-A in MDCK cells enhances the motility of singly migrating cells but reduces cell motility of cells embedded in a collective by impairing the dynamics of cryptic lamellipodia formation. This activity of JAM-A is observed in cells grown on laminin and collagen I but not on fibronectin or vitronectin. Accordingly, we find that JAM-A exists in a complex with the laminin- and collagen I-binding α3β1 integrin. We also find that JAM-A interacts with CD151, a tetraspanin that forms a stoichiometric complex with α3β1 integrin and that regulates α3β1 integrin activity in different contexts. Mapping experiments indicate that JAM-A associates with both α3β1 integrin and CD151 through its extracellular domain. Similar to depletion of JAM-A, depletion of either α3β1 integrin or CD151 in MDCK cells slows down collective cell migration. Our findings suggest that JAM-A, α3β1 integrin and CD151 exist as a functional complex to regulate collective cell migration of epithelial cells.
Evaluation of Deep Learning models on UV ink : a Fake Money detection scheme with RPN
Authors: Chowdhury Anjir Ahmed , Das Argho , Karmaker Debajyoti 
Published: August 2021

Abstract
As soon as coins or money was invented, there were people trying to make counterfeits. Counterfeit money is fake money that is produced without the permission of the state or government, usually to imitate the currency and deceive the intended recipient. In Bangladesh, this is a significant problem and the problem is becoming more and more phenomenon as the days are passing by. Today’s modern bank notes have several security features that makes easier to identify fake notes. One of the security features is the use of UV ink. Bank notes deliberately put random flecks of color scattered all over the surface of the money - which acts as a extra layer of protection against counterfeiters. We propose an automatic authentication model for identifying counterfeit money based on these random flecks of color which is visible under UV light. To obtain a benchmark result, existing object detection pre-trained models were used, followed by MobileNet, Inception, ResNet50, ResNet101, and Inception-ResNet architectures. After that, using the Region Proposal Network (RPN) method with Convolutional Neural Network (CNN) based classification the optimal model was proposed. The proposed model had a 96.3 percent accuracy. It is critical to reduce the circulation of counterfeit money in a country’s economy to stop inflation. This study will aid in the detection of counterfeit money and, hopefully, reduce its spread.
Diffusion and Memory Effect in a Stochastic Processes and the Correspondence to an Information Propagation in a Social System
Authors: Wang Peng , Huo Jie , Wang Xu-Ming 
Published: August 2021

Abstract
A generalized Langevin equation is suggested to describe a diffusion particle system with memory. The equation can be transformed into the Fokker-Planck equation by using the Kramers-Moyal expansion. The solution of Fokker-Planck equation can describe not only the diffusion of particles but also that of opinion particles based on the similarities between the two. We find that the memory can restrain some non-equilibrium phenomena of velocity distribution in the system, without memory, induced by correlation between the noise and space[1]. However, the memory can enhance the effective collision among particles as shown by the variation of diffusion coefficients, and changes the diffusion mode between the dissipative and pumping region by comparing with that in the aforementioned system without memory. As the discussions in this physical system is paralleled to a social system, the random diffusion of social ideology, such as the information propagation, can be suppressed by the correlation between the noise and space.
Novel QTL For Lodging Resistance, PRL4, Improves Physical Properties With High Non-Structural Carbohydrate Accumulation of Basal Culms in Rice (Oryza Sativa L.)
Authors: Kashiwagi Takayuki 
Published: August 2021

Abstract
Resistance to lodging, an important problem in rice production, has three types: low plant height, strong culm, and high strength of the lower part of the plant. The determinants of strength of the lower part remains unclear, compared with plant height and culm strength. This study identified a new genetic factor involved in the strength of the lower part, as assessed by pushing resistance, using chromosomal segment substitution lines (CSSLs) to clarify the determinants of strength of the lower part by functional analysis of the CSSL and the near isogenic line (NIL) harboring the identified quantitative trait locus (QTL). QTL analysis identified the QTL for increasing pushing resistance on chromosome 4, PRL4, which was not related to days to heading. The CSSL with PRL4 showed increased pushing resistance and physical strength of the basal culm, but decreased filled grain ratio and grain weight. The NIL with PRL4, developed by backcrossing this CSSL, improved pushing resistance and the strain of culm until breaking under compression, and did not decrease yield traits. These lines with PRL4 increased the accumulation of non-structural carbohydrate (NSC) in the basal culm at the fully ripe stage. Thus, the genetic control of NSC accumulation in culms by PRL4 may improve the strength of the lower part by enhancing culm toughness with strength and ductility.
Sensitivity Experiments on the Role of Water Vapor in the Eastward Propagation of MJO
Authors: Zhu Xiaoyu , Zhong Zhong , Zhu Yimin , Hu Yijia , Ha Yao , Guo Tao 
Published: August 2021

Abstract
In this study, we employed the nudging assimilation of the Weather Research and Forecasting (WRF) model to conduct a set of sensitivity experiments on the role of water vapor in the Madden-Julian Oscillation (MJO) eastward propagation, focusing on the eastward propagating 30-60d low-frequency component in the tropical atmosphere from the Indian Ocean to the western Pacific Ocean during September-November 2004. Using 11 different cumulus parameterization schemes, the simulation results show that the ability of the regional climate model in simulating the MJO eastward propagation is sensitive to the cumulus scheme: A suitable scheme can well reproduce the MJO eastward propagation characteristics, while most schemes show no skill for the MJO eastward propagation. When the water vapor in the model domain was assimilated using reanalysis data with nudging technique, we found that the low-frequency evolution of the tropical zonal wind exhibits MJO features well, and the low-frequency phase of water vapor is ahead of the zonal wind by about 6-7 days, which suggests that the atmospheric water-vapor distribution is the key factor for the eastward propagation of the MJO, and the effect of water-vapor field via affecting the atmospheric stability. When the atmospheric temperature assimilation was conducted, there was almost no improvement in the skill of MJO simulation.
Intervention of resource allocation strategies on spatial spread of epidemic
Authors: Zhang Kebo , Han Yuexing , Gou Min , Wang Bing 
Published: August 2021

Abstract
Medical resources are crucial in mitigating the epidemic, especially during pandemics such as the ongoing COVID-19. Thereby, reasonable resource deployment inevitably plays a significant role in suppressing the epidemic under limited resources. When an epidemic breaks out, people can produce resources for self-protection, or donate resources to help others. That is, the exchange of resources also affects the transmission between individuals, thus, altering the epidemic dynamics. To understand factors on resource deployment and the interplay between resource and transmission we construct a metapopulation network model with resource allocation. Our results indicate actively or promptly donating resources is not helpful to suppress the epidemic under both homogeneous population distribution (HOD) and heterogeneous population distribution (HED). Besides, strengthening the speed of resource production can significantly increase the recovery rate so that reduce the final outbreak size. These results may provide policy guidance towards epidemic containment.
Identifies Immune-Related Gene Pair Signature Associated with Breast Cancer Prognosis
Authors: Sun Tianwei , Tan Qixing , Wei Changyuan 
Published: August 2021

Abstract
Background: Breast cancer (BC) is the cancer with the largest number of deaths in women. There is growing evidence that immunity plays an important role in the prognosis of breast cancer. Methods: In this study, we developed and validated an immune-related gene pair signature (IRGPs) to predict the survival of breast cancer patients. Screening immune-related genes from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database for the construction of IRGPs, and patients with breast cancer in these two cohorts were assigned to low- and high- risk subgroups. Additionally, we used Kaplan-Meier survival analysis, univariate and multivariate Cox analysis to investigate IRGPs and their individualized prognostic characteristics, and analysis of immune cell infiltration in breast cancer. Results: A 47-IRGP signature was constructed from 2498 immune genes, which could significantly predict the overall survival (OS) of breast cancer patients in the TCGA and GEO cohorts. Immune infiltration analysis showed that a variety of immune cells are significantly related to the prognostic effects of IRGP characteristics in breast cancer patients, especially CD8+ T cells and macrophages. Conclusions: The IRGP signature constructed in this study can help determine the prognosis of breast cancer and provide new ideas and basis for future research on the role of immune-related genes in breast cancer patients.
TPP1 Regulates hTERT Expression and Predicts Early Malignant Event and Prognosis of Cervical Cancer
Authors: Wang Qiaoli , Gong Caifeng , Yang Hui , Zhou Fuxiang , Wu Qiuji , Zhou Yunfeng 
Published: August 2021

Abstract
Background: Cervical cancer is one of the most common deadly cancer in women worldwide. However, identifying specific biomarkers is still needed. Telomere-binding protein 1 (TPP1) is vital to telomerase activity. However, the role of TPP1 in cervical cancer and its association with human telomerase reverse transcriptase (hTERT) is unclear.This study aimed at exploring the role of telomere-binding protein 1 (TPP1) in cervical cancer development and progression, and potential mechanisms.Methods: Tissue samples from a total of 274 participants were enrolled for the evaluation of protein expression,156 of whom diagnosed withcervical cancers, 102 with cervical intraepithelial neoplasia (CIN) and 16 with normal cervix. In addition, in vitro cellular models with cervical cancer cell lines Hela, Siha, and C33a were transfected by TPP1-siRNAand protein expression of TPP1 and hTERT were assessed. Results: Compared with normal cervix, TPP1 expression was significantly higher in CIN-III and cervical cancers (P<0.001 for both). High expression of TPP1alone (Plog-rank=0.047)andhigh co-expression of TPP1/hTERT (Plog-rank=0.005)weresignificantly associated with worse survival of cervical cancer patients.After adjusting for well-known prognosis factors, hazard ratio was 2.03(95% confidence interval [CI] 0.99-4.16)for high expression of TPP1 and 2.01(95% CI 1.10-3.67) for high co-expression of TPP1/hTERT. TPP1 and hTERT expressions were positively correlated atall levels of cervical lesions (r=0.524, P<0.001). Knockdown of TPP1 decreased hTERT mRNA and protein expression.Conclusions: High expression of TPP1 might be an early event during cervical cancer development and could be served as apotential prognosis biomarker, especially when used together with hTERT. TPP1 might regulate hTERT expression with detailed underlying mechanisms warrant further investigation.
Biochar from Oil Cakes: An Efficient Adsorbent for the Removal of Acid Dyes From Wool Dye House Effluent
Authors: jose seiko , Roy Reena , Phukan Ava , Shakyawar Dinesh , Sankaran Anuradha 
Published: August 2021

Abstract
Textile dyeing industries are one of the major culprits for environmental pollution. The industries are adopting various processes for the removal of dyes and chemicals from the effluent before disposing to the land or water bodies. In the reported study, biochars were prepared from almond, coconut, and mustard oil cakes by chemical activation with phosphoric acid followed by low temperature pyrolysis. The ball milling technique was employed to reduce the particle size of the biochars below 300 nm. The synthesized biochars were used for the removal of color from the acid dye effluent from the wool dyeing unit. The results showed that very small quantities (2.0 %) of biochars are sufficient to remove around 92% color from the dye effluent. The batch adsorption and kinetic studies indicate the highest efficiency of color removal for the biochar derived from almond oil cake, followed by mustard and coconut. The adsorption properties of the synthesized biochars were found to be greatly depending on the type of oil cake used. It is concluded that the biochars produced from the oil cakes may be a partial replacement of petroleum based activated carbon for the color removal from wool textile dye effluent.
Reversal Flow in the Left Anterior Descending Artery After Internal Thoracic Artery Grafting
Authors: Nakajima Hiroyuki , Takazawa Akitoshi , Nakamura Yoshitsugu , Ishibashi-Ueda Hatsue , Yoshitake Akihiro , Iguchi Atsushi 
Published: August 2021

Abstract
Background: The flow capacity of the in situ internal thoracic artery (ITA) is not necessarily sufficient and can be a cause of hypoperfusion syndrome. We present a catastrophic case of in situ ITA grafting for an isolated left main trunk obstruction 13 years after modified Bentall operation. Case presentation: A 33-year-old woman had previously undergone a modified Bentall operation. Coronary angiography showed a critical stenosis in the left coronary artery. The patient underwent emergent off-pump CABG with the left internal thoracic artery (ITA) to the left anterior descending artery (LAD). On the seventh day, the patient had severe dyspnoea and hypotension. Catheter angiography showed that the ITA was patent, but blood flow from the in situ ITA was delayed, and reversal flow from the apex to the proximal LAD was found. The patient underwent implantation of a left ventricular assist device. Conclusions: In conclusion, concomitant aortocoronary bypass to the circumflex branch will minimise the risk of hypoperfusion, especially for a young patient without atherosclerotic disease.
Not a Coincidental Concurrence of Breast Carcinoma and Cardiac Myxoma: Case Report
Authors: Kong Ling-Yun , Xiang Wei , Chen Ling-Ling , Shen Dong-Yan , Liu Fang 
Published: August 2021

Abstract
Background: Myxoma has been considered to undergo a simple and benign process but not always so. Case presentation: A female patient was admitted for evaluation of left breast nodule. Physical examination showed facial pigmentation, left breast nodule and 3/6 diastolic murmur at the mitral valve area. Preoperative echocardiography revealed a massive mobile left atrial mass attaching to the interatrial septum causing obstruction to mitral orifice. Histopathologic investigation confirmed the left atrial mass to be myxoma and left breast nodule to be cancer. Carney complex was considered and lifelong follow-up was advised. Conclusion: Cardiac myxoma may present as a part of a systematic disease entity. In patients with a combination of breast nodule and facial pigmentation, transthoracic echocardiography examination is advised to guide decision-making.
Declined eGFR Associated with Poor Prognosis in COVID-19 Patients in Wuhan, China: A Retrospective Cohort Study
Authors: Zhang Wei-yun , Zhou Si-jing , Liu Ying-ying , Zhang Meng-lan , Wang Yu-ji , Jiang Jun-hong , Wang Ran , Zeng Da-xiong 
Published: August 2021

Abstract
Background: Increasing evidence revealed that kidney was one of the targets of SARS-CoV-2. However, the incidences of kidney abnormalities were significantly different, from 0.5 to 75.4% in coronavirus disease 2019 (COVID-19) patients. The association of kidney injury with prognosis remain controversial.Methods: In this retrospective cohort study, laboratory confirmedCOVID-19inpatients with severe type were enrolled. Demographic, clinicaland laboratory data were collected. Association of estimated glomerular fifiltration rate (eGFR)with 28-days mortality was analyzed.Results: The total 28-days mortality of hospitalizationwas 22.3% (79/354). Non-survivors had a significantly declined eGFR levels than survivors (75.95 [IQR: 47.22,92.84] ml/min/1.73m2 vs. 96.43 [IQR: 84.11,108.47] ml/min/1.73m2, P<0.001). The 28-days mortality in declined eGFR group (<90 ml/min/1.73m2) was significantly higher than that in normal eGFR group (38.5% vs. 10.7%, P <0.001). Multivariate logistic regression revealed that the independent risk factors of 28-days outcome included lower eGFR (OR: 3.97, 95%CI: 1.42-11.11), elevated WBC (OR: 7.08, 95%CI: 3.15-15.90), lymphopenia (OR: 2.58, 95%CI: 1.21-5.49)andIL-6 (OR: 7.90, 95%CI: 2.19-28.49). Kaplan-Meier analysis indicated the survival disadvantage in patients with declined eGFR. ROC curve showed the eGFR cut-off value for predicting 28-days death was 82.2 μmol/L, with the sensitivity of 76.7% and speciality of 66.3%.Conclusion: Declined eGFR was associated with poor prognosis and could be used an independent risk factor of 28-days mortality in COVID-19 patients. Early detection and surveillance for eGFR may benefit to identify patients with high-risk ofprogression.
Activated TAZ Induces Liver Cancer in Collaboration with EGFR/HER2 Signaling Pathways
Authors: Moon Hyuk , Choi Hye Jin , Kim Do Young , Ro Simon Weonsang 
Published: August 2021

Abstract
Liver cancer is a major global health concern due to the steady increases in its incidence and mortality. Transcription factors, yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ)have emerged as critical regulators in human hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), the two major types of primary liver cancer. However, our study as well as other previous reports have shown that activation of YAP and TAZ (YAP/TAZ) in adult murine livers is insufficient for the development of liver cancer, suggesting a requirement for an additional oncogenic collaborator for liver carcinogenesis in adulthood. Therefore,we sought to identifythe oncogenic partners of YAP/TAZ that promote hepatocarcinogenesis in adults. Through database analyses, we identified EGFR/HER2signaling to be essential in human cancerswith high TAZ activity.Furthermore,immunohistochemical analyses showedthat human HCC and CC tissues with high YAP/TAZ activities exhibited concomitant activation of EGFR/HER2downstream signaling pathways. To demonstrate that EGFR/HER2 signaling promotes YAP/TAZ-mediated hepatocarcinogenesis, a constitutively active form of TAZ was simultaneously expressed in murine adult livers with effector molecules downstream of EGFR/HER2 signaling pathways.Interestingly, activated TAZ and BRAFinduced HCC, whereas activated TAZ and PI3K led to the development of CC-like cancer, demonstrating that TAZ collaborates with EGFR/HER2 signaling pathways to induce both HCC and CC.
Ursodeoxycholic Acid (UDCA) Increases Lactate Clearance and Reduces Liver Injury by Inhibiting Farnesoid X Receptor (FXR) in Hemorrhagic Shock (HS)
Authors: Wang Lu , Rui Xi , He Huai-Wu , Zhou Xiang , Long Yun 
Published: August 2021

Abstract
Background: Hemorrhagic shock (HS) is one of the leading causes of death worldwide. Acute liver injury (ALI) is an important manifestation of HS. Farnesoid X receptor (FXR) plays an important role in the liver protection of bile acids. Therefore, we designed this experiment to study the effect of ursodeoxycholic acid (UDCA) on acute liver injury and its relationship with the FXR pathway in HS.Methods: In this study, eighteen adult male C57BL/6 mice were randomly divided into 3 groups of six mice per group applying a table of random numbers: sham group; HS group and HS + UDCA group. Six FXR (-/-) adult male C57BL mice were classified as FXR (-/-) + HS + UDCA group. As to model of HS, MAP of 40 ± 5 mmHg was maintained for 1 hour. As to UDCA intervention, UDCA (300mg/kg) was given nasally fed. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) were quantified with chromatographic quantitative kits according to the manufacturer’s instructions. Lactate concentration was determined by an automatic biochemical analyzer. The liver tissues were stained with hematoxylin and eosin (H&E) and scored histopathologically.Results: Plasma ALT, AST and lactate levels decreased significantly after treatment with UDCA under HS conditions. Pathological scores of liver tissues decreased significantly after treatment with UDCA under HS conditions. In the case of FXR (-/-), the influence of UDCA was inhibited.Conclusions: UDCA can reduce ALT, AST and lactate levels and alleviate liver injury during HS through the FXR pathway.
Wheat Posture Acquisition System Based on Infrared Tracer Robot Design and Experiment
Authors: fu xiuqing , He Jianbo , Sun Zhuangzhuang , Zhang Hongwen , Xian Jieyu 
Published: August 2021

Abstract
Background:To investigate the effect of drought stress on wheat posture.Methods:An image acquisition system based on an infrared tracing robot was developed and a graphical user interface (GUI) software was designed to simplify the operation control of the robot. In this experiment, three genotypes of wheat, Ruihuamai 523, Jimai 22 and Xumai 33, were grown in indoor pots, and the images of wheatposture from flowering stage to maturity were collected to extract morphological parameters such as plant height, stem width and leaf inclination angle. Results:The experimental results showed that the deviation of linear trajectory was less than 3 mm when the robot traveled in a straight line at 0.4 m/s in the greenhouse; the image acquisition efficiency was about 18 images/min;the collected pictures of drought-stressed and control potted wheat groups can be used for posture assessment; the accuracy of wheat plant height and stem width with manual acquisition was 84.6% and 79.2%, respectively. After statistical analysis, it was concluded that drought stress and genotype and other influencing factors had no significant effect on plant height and stem width, but had a greater effect on leaf inclination angle.Conclusions:Therefore, this system can be used for posture collection of wheat.