bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desarrollo de la expresión oral en FLE: la Francofonía y las TIC
Authors: Asensio Ferreiro Mª Dolores 
Published: December 2021

Comunicarse de manera efectiva y apropiada en una lengua extranjera (FL) implica dominar las cuatro habilidades lingüísticas, comprensión y expresión escritas (CE-EE) y comprensión y expresión oral (CO-EO). Sin embargo, no se desarrollan al mismo nivel durante el proceso de enseñanza-aprendizaje en entornos formales. El desarrollo de la expresión oral en FFL es a menudo un desafío para los profesores debido a condicionantes tales como la falta de motivación y sentimientos de inhibición, falta de seguridad o confianza en sí mismo del alumno. A estos, se suman otros como falta de tiempo, grandes grupos de alumnos o vacíos metodológicos y evaluativos que complican la práctica de esta competencia en el aula. Este trabajo presenta un proyecto educativo implementado en la clase FLE donde la Francofonía, el uso de las TIC y el aprendizaje colaborativo son fundamentales para desarrollar la expresión oral del aprendientee al mismo tiempo que ayuda a fortalecer sus habilidades personales.
Communicating effectively and appropriately in a SL implies mastering the four language skills, i.e. written comprehension and expression and oral comprehension and expression. However, not all develop equally during the teaching-learning process in formal contexts.The development of oral expression in FFL is often a challenge for teachers and students due to conditions such as lack of motivation and feelings of inhibition of the students, lack of security or self-confidence. To these are added others such as lack of time, large groups of students or methodological and evaluative gaps that contribute significantly to hinder the practice of this competence in the classroom. This paper presents a teaching project implemented in the FFL classroom where Francophonie, the use of ICT and collaborative learning are key to developing the oral expression of the learner contributing to reinforcing their personal skills.
Communiquer efficacement et de manière appropriée dans une langue étrangère (LE) implique de maîtriser les quatre compétences linguistiques, la compréhension et expression écrites (CE-EE) et la compréhension et expression orales (CO-EO). Cependant, elles ne se développent pas au même niveau au cours du processus d’enseignement-apprentissage dans des contextes formels. Le développement de l’expression orale en FLE est souvent un défi pour les enseignants en raison de conditions tellles que le manque de motivation et les sentiments d’inhibition de l’élève, le manque de sécurité ou de confiance en soi. À ceux-ci s’ajoutent d’autres comme le manque de temps, de grands groupes d’étudiants ou des lacunes méthodologiques et évaluatives qui réduisent la pratique de cette compétence en classe. Cet ouvrage presente un projet pédagogique mis en oeuvre en classe FLE où la Francophonie, l’utilisation des TIC et l’apprentissage collaboratif sont essentiels pour développer l’expression orale de l’apprenant en même temps qu’elle contribue à renforcer ses compétences personnelles.
Représentations interculturelles dans le discours touristique des Blogs de voyages français: une vision de l'Andalousie stéréotypée?
Authors: Cantón Rodríguez María Loreto 
Published: December 2021

El desarrollo del discurso turístico en Internet ha cambiado la manera de diseñar y vender el producto turístico.En una decena de años hemos pasamos de hablar del turismo 2.0 al turismo 4.0. Este nuevo discurso integra el oral y el escrito para persuadir y convencer al turista internauta que ahora es emisor y receptor de un mismo producto.Esta nueva visión del Otro a partir de la práctica digital de los blogs de viaje será el objeto de esta contribución.
Ofreceremos, en primer lugar, una visión general teórica de este nuevo discurso turístico, que ha renovado la manera de concebir la imagen de un país y sus identidades, a partir de la opinión de estos blogueros-turistas. Nuestro análisis se centrará, posteriormente, en la visión de Andalucía que estos viajeros dibujan diariamente en los blogs para verificar si la imagen que se traslada es engañosa, estereotipada o realza aspectos desconocidos de esta región para el potencial turista.
The development of tourism discourse on the Internet has changed the way to design and sell the tourist product. In ten years, we have gone from talking about tourism 2.0 to tourism 4.0. This new discourse integrates oral and written discourse to persuade and convince the Internet tourist, who is now both transmitter and receiver of the same product. This new vision of the Other considered from the digital practice of travel blogs will be the subject of this contribution.
Firstly, we will offer a theoretical overview of this new tourism discourse, which has renewed the way of conceiving the image of a country and its identities, based on the opinion of these blogger-tourists. Our analysis will then focus on the vision of Andalusia drawn daily by these travelers in blogs, to verify whether the image conveyed is misleading, stereotyped or enhances unknown aspects of this region for the potential tourist.
Le développement du discours touristique sur Internet a changé la manière de concevoir et de vendre le produit touristique.En une dizaine d’années, nous sommes passés du tourisme 2.0 au tourisme 4.0. Ce nouveau discours intègre l’oral et l’écrit pour persuader et convaincre le touriste internaute qu’il est maintenant l’émetteur et le récepteur d’un même produit.Cette nouvelle vision de l’Autre à partir de la pratique numérique des blogs de voyage fera l’objet de cette contribution.Nous offrirons, en premier lieu, un aperçu théorique de ce nouveau discours touristique, qui a renouvelé la manière de concevoir l’image d’un pays et ses identités, à partir de l’avis de ces blogueurs-touristes. Notre analyse se concentrera ensuite sur la vision de l’Andalousie que ces voyageurs dessinent quotidiennement dans les blogs pour vérifier si l’image qui se déplace est trompeuse, stéréotypée ou met en valeur des aspects inconnus de cette région pour le touriste potentiel.
Boosting Continuous‐Wave Laser‐Driven Nonlinear Photothermal White Light Generation by Nanoscale Porosity
Authors: Zheng Guojun , Liu Xiaofeng , Wu Jianhong , Zhang Dao , Zhang Duoduo , Xu Zhousu , Cui Yanxia , Qiu Jianrong , Strek Wieslaw 
Published: December 2021

AbstractThe irradiation of an optically absorptive medium by a continuous‐wave (CW) near‐infrared (NIR) laser can result in a spectral continuum emission covering both the visible and NIR regions, which is attractive for applications as continuum light sources in diverse fields. It is shown here that this NIR‐laser‐driven light emission can be effectively modulated with nanoscale architecture in the medium. By using porous silica as the model matrix and Yb3+ ions as the photothermally active centers, up to 100 folds increment in NIR‐laser‐induced emission intensity and dramatic decrease in threshold excitation density are demonstrated. It is observed that the emission intensity exhibits a strong nonlinear dependence on the power of the NIR excitation laser, featuring clear excitation power thresholds. Based on combined numerical simulation and spectral and temperature measurements, the improved broadband emission and photothermal nonlinearity are interpreted by enhanced optical energy localization around the laser spot that results in boosting the photon‐to‐photon conversion efficiency. The use of the nonlinear photothermal emission process as a broadband NIR light source, which could be exploited for applications including NIR spectroscopy, imaging, and sensing, is further demonstrated as a proof‐of‐concept.
Sleep problems in fragile X syndrome: Cross‐sectional analysis of a large clinic‐based cohort
Authors: Budimirovic Dejan B. , Protic Dragana D. , Delahunty Carol M. , Andrews Howard F. , Choo Tse‐Hwei , Xu Qing , Berry‐Kravis Elizabeth , Kaufmann Walter E. ,   for the FORWARD Consortium
Published: December 2021

AbstractFragile X syndrome (FXS), the leading cause of inherited intellectual disability and autism spectrum disorder, is associated with multiple neurobehavioral abnormalities including sleep difficulties. Nonetheless, frequency, severity, and consequences of sleep problems are still unclear. The Fragile X Online Registry with Accessible Research Database (FORWARD‐version‐3), including Clinician Report and Parent Report forms, was analyzed for frequency, severity, relationship with behavioral problems, and impact of sleep difficulties in a mainly pediatric cohort. A focused evaluation of sleep apnea was also conducted. Six surveyed sleep difficulties were moderately frequent (~23%–46%), relatively mild, affected predominantly younger males, and considered a problem for 7%–20% of families. Snoring was more prevalent in older individuals. All sleep difficulties were associated with irritability/aggression and most also to hyperactivity. Only severe snoring was correlated with sleep apnea (loud snoring: 30%; sleep apnea: 2%–3%). Sleep difficulties are prevalent in children with FXS and, although they tend to be mild, they are associated with behavioral problems and negative impact to families. Because of its cross‐sectional nature, clinic‐origin, use of ad hoc data collection forms, and lack of treatment data, the present study should be considered foundational for future research aiming at better recognition and management of sleep problems in FXS.
Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies
Authors: Long Ashlee , Crouse Andrew , Kesterson Robert A. , Might Matthew , Wallis Deeann 
Published: December 2021

AbstractVariants within the Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) gene have been discovered to play a role in developmental and epileptic encephalopathies, a group of debilitating conditions for which little is known about cause or treatment. Here, we determine the functional consequences of two variants: p.Tyr434Cys (Y434C) (located in the transmembrane domain) and p.Thr720Ile (T720I) (located in the catalytic domain). Wild‐type and variant cDNAs were constructed and transfected into HEK293 cells. In cell culture, variant Y434C exhibited ligand‐independent activation of tropomyosin‐related kinase B (TRKB) signaling with an associated abnormal response to brain‐derived neurotrophic factor (BDNF) stimulation and increased levels of phosphorylated extracellular signal‐regulated kinase (ERK) and ETS like‐1 protein (ELK1) activity. Expression of variant T720I resulted in decreased TRKB signaling with reduced mTor activity as determined by decreased levels of phosphorylated S6. With the deleterious mechanisms characterized, we utilized mediKanren (a novel artificial intelligence tool) to identify therapeutics to compensate for the pathological effects. Downregulation of TRKB through inhibition with mediKanren‐predicted compound 1NM‐PP1 led to decreased MEK activity. Upregulation of TRKB signaling by mediKanren‐predicted valproic acid led to subsequent increase of mTor activity. Overall, our results provide further characterization of the pathogenicity of these two variants in the NTRK2 gene. Indeed, Y434C is the first patient‐specific NTRK2 variant with demonstrated hypermorphic activity. Furthermore, we observed that variants Y434C and T720I result in distinct functional consequences that require distinct therapeutic strategies. These data suggest the possibility that unique mutations within different regions of the NTRK2 gene results in separate clinical presentations, representing distinct genetic disorders requiring unique therapeutics.
Modelling the effects of variation in growth, recruitment, and harvest on lake sturgeon population viability and recovery
Authors: Nelson Patrick A. , McDougall Craig A. , Koops Marten A. , Barth Cameron C. 
Published: December 2021

Abstract

Regulatory agencies and fisheries managers tasked with implementing recovery plans for endangered species must frequently make decisions based on limited data, while also considering general uncertainty associated with prediction. Population viability analysis (PVA) is a modelling tool that is particularly useful for long‐lived species and can be applied even in the absence of robust estimates of life history parameters. As empirical data are accumulated over time, PVA inputs, model structure, and parameter estimates can be refined to increase model realism and accuracy.
Since the first iterations of lake sturgeon (Acipenser fulvescens) PVA were run, approximately 15 years ago, based on conservative inputs for Canadian population units, important empirical data have accumulated from a variety of river systems that the species inhabits. Erratic recruitment patterns have been revealed, juvenile survival has been determined to be higher than initially believed, and growth rates have been found to vary by habitat (river) type.
Exploiting an improved biological understanding of the species, somatic growth models derived from three well‐studied lake sturgeon populations were used to examine the effects of recruitment variability and incremental levels of adult harvest (mortality) on the probability of population recovery and risk of population decline. A total of 110 PVA scenarios (with 1,000 replicates per scenario) were run for each of the three somatic growth models (slow, medium, and fast).
The PVA results suggest that the recovery potential for lake sturgeon populations may be higher than previous models, based on conservative inputs, have indicated. A few scenarios resulted in recovery after 100 years, and nearly half of the scenarios resulted in recovery after 250 years. Similarly, the probability of decline for small populations was most sensitive to adult harvest, with little change in the number of scenarios resulting in decline at the time points of 100, 250, and 500 years. A worked example highlights how the targeted monitoring of both juvenile and adult life stages can be used to evaluate the recovery potential of more than one population and prioritize management initiatives, such as harvest reduction and stocking.
Electrodeposition of Cu onto Au(111) from Deep Eutectic Solvents: Molar Ratio of Salt and Hydrogen Bond Donor
Authors: Geng Tanja , Zeller Sven J. , Kibler Ludwig A. , Ceblin Maximilian U. , Jacob Timo 
Published: December 2021

AbstractThe electrodeposition of copper onto Au(111) from Deep Eutectic Solvents (DESs) type III has been studied by cyclic voltammetry. Investigations were carried out with mixtures of choline chloride (ChCl) and ethylene glycol (EG) or trifluoroacetamide (TFA). The eutectic compositions and temperatures were determined by differential scanning calorimetry (DSC). For the ChCl/EG DES, a eutectic ratio of 16 : 84 (ChCl:EG) was found instead of the previously reported ratio of 33 : 67. The electrodeposition of copper was studied for electrolytes with different ratios of ChCl to hydrogen bond donor (HBD) to resolve the influence of the composition on the deposition behavior. Both CuCl and CuCl2 were used as Cu salts. Underpotential deposition (UPD) is followed by bulk deposition with the diffusion rate of Cu species being dependent on the ratio of ChCl to HBD. With CuCl2, both Cu+ and Cu2+ species are reduced and deposited, whereby the two‐electron reduction is more dominant with higher chloride content and presence of EG. However, the properties of the Cu electrodeposition do not result from the freezing‐point depression of the DESs, but from the high concentration of ions.
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference
Authors: Hershman Rebecca L. , Li Yamin , Ma Feihe , Xu Qioabing , Van Deventer James A. 
Published: December 2021

AbstractMany intracellular signaling events remain poorly characterized due to a general lack of tools to interfere with “undruggable” targets. Antibodies have the potential to elucidate intracellular mechanisms via targeted disruption of cell signaling cascades because of their ability to bind to a target with high specificity and affinity. However, due to their size and chemical composition, antibodies cannot innately cross the cell membrane, and thus access to the cytosol with these macromolecules has been limited. Herein we describe strategies for accessing the intracellular space with recombinant antibodies mediated by cationic lipid nanoparticles to selectively disrupt intracellular signaling events. Together, our results demonstrate the use of recombinantly produced antibodies, delivered at concentrations of 10 nM, to selectively interfere with signaling driven by a single posttranslational modification. Efficient intracellular delivery of engineered antibodies opens up possibilities for modulation of previously “undruggable” targets, including for potential therapeutic applications.
Timo: In‐memory temporal query processing for big temporal data
Authors: Zheng Xiao , Liu Houkai , Wang Xiujun , Wu Xuangou , Yu Feng 
Published: December 2021

AbstractToday's internet applications generate massive temporal data anywhere and anytime. Although some disk‐based temporal systems are currently available, they suffer from poor I/O performance, especially when applied in intelligent applications deployed in the cloud and edge environments. Therefore, how to process temporal operations with low latency and high throughput becomes a crucial problem for efficient data processing. This paper proposes Timo, a distributed in‐memory temporal query and analytic model for big temporal data. Firstly, a space‐efficient temporal index is proposed to support more efficiently query performance with less memory space than the state‐of‐art methods. Secondly, based on the temporal locality feature of temporal queries, Timo proposes a partitioner mechanism, which utilizes forward scan algorithm, to improve query throughput. Thirdly, some optimal strategies are proposed to improve the execution process of temporal query and analysis, which reduce intermediate result data size and improve the throughput much further. Lastly, we implement the Timo system on the Apache Spark platform, which extends Spark dataset API with temporal query and analysis API functions for users. Extensive experimental results show that the Timo system outperforms other Spark‐based temporal systems in terms of both query latency and throughput.
Pyridine‐Containing Donor‐Acceptor Diarylnitroxides: Noncovalent Stabilization of the Redox States
Authors: Levitskiy Oleg A. , Bogdanov Alexey V. , Klimchuk Ivan A. , Magdesieva Tatiana V. 
Published: December 2021

AbstractA series of new pyridyl‐ or 2‐pyridyloxide‐containing donor‐acceptor diarylnitroxides was obtained and characterized; high stability of the ortho‐2‐pyridyl‐containing diarylnitroxides was determined by kinetic measurements (τ1/2=1733 h in benzene). Comparative voltammetric study of new nitroxides and their analog in which the Py replaces the Ph group revealed both through‐bond and through‐space stabilization of the NO redox states with the pyridyl/ 2‐pyridyloxide moiety, providing reversibility of both oxidation and reduction processes. Adaptive conformational behavior of new pyridyl/pyridyloxide containing nitroxides upon one‐electron oxidation and reduction was confirmed by DFT calculations. Stimuli‐responsive conformational changes allow switching on/off dispersion and electrostatic interactions within the molecule and increase stability of the redox states. Spectroelectrochemical measurements provided experimental evidence for reversibility of the through‐space stabilization of the oxidized state of the nitroxides with the neighboring pyridine lone pair.
Using social values in the prioritization of research: Quantitative examples and generalizations
Authors: Falcy Matthew R. 
Published: December 2021

Abstract

Identifying critical uncertainties about ecological systems can help prioritize research efforts intended to inform management decisions. However, exclusively focusing on the ecological system neglects the objectives of natural resource managers and the associated social values tied to risks and rewards of actions.

I demonstrate how to prioritize research efforts for a harvested population by applying expected value of perfect information (EVPI) to harvest decisions made with a density‐independent matrix population model. Research priorities identified by EVPI diverge from priorities identified by matrix elasticity analyses that ignore social utility.

Using a density‐dependent harvest model, the value of information about the intrinsic productivity of a population is shown to be sensitive to the socially determined penalty for implementing a harvest rate that deviates from the goal because of imperfection in estimation.

Synthesis and applications. The effect of including social values into harvest decision‐making depends on the assumed population model, uncertainty in population vital rates, and the particular form of the utility function used to represent risk/reward of harvest. EVPI analyses that include perceived utility of different outcomes can be used by managers seeking to optimize monitoring and research spending. Collaboration between applied ecologists and social scientists that quantitatively measure peoples' values is needed in many structured decision‐making processes.
Phenotype analysis of cultivation processes via unsupervised machine learning: Demonstration for Clostridium pasteurianum
Authors: Hong Yaeseong , Nguyen Tom , Arbter Philipp , Utesch Tyll , Zeng An‐Ping 
Published: December 2021

AbstractA novel approach of phenotype analysis of fermentation‐based bioprocesses based on unsupervised learning (clustering) is presented. As a prior identification of phenotypes and conditional interrelations is desired to control fermentation performance, an automated learning method to output reference phenotypes (defined as vector of biomass‐specific rates) was developed and the necessary computing process and parameters were assessed. For its demonstration, time series data of 90 Clostridium pasteurianum cultivations were used which feature a broad spectrum of solventogenic and acidogenic phenotypes, while 14 clusters of phenotypic manifestations were identified. The analysis of reference phenotypes showed distinct differences, where potential conditionalities were exemplary isolated. Further, cluster‐based balancing of carbon and ATP or the use of reference phenotypes as indicator for bioprocess monitoring were demonstrated to highlight the perks of this approach. Overall, such analysis depends strongly on the quality of the data and experimental validations will be required before conclusions. However, the automated, streamlined and abstracted approach diminishes the need of individual evaluation of all noisy dataset and showed promising results, which could be transferred to strains with comparably wide‐ranging phenotypic manifestations or as indicators for repeated bioprocesses with clearly defined target.