bluuebunny/crossref_metadata_2025_split huggingface dataset:
A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
Authors: Petersen Inga , Morrison Jamie I. , Petrovic Alex , Babic Neira , Metzendorf Nicole G. , Godec Ana , de la Rosa Andrés , Rofo Fadi , Bondza Sina , Buijs Jos , Ranjbarian Farahnaz , Hofer Anders , Sehlin Dag , Hultqvist Greta 
Published: December 2024

AbstractTransferrin Receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) enables the uptake of bispecific therapeutic antibodies into the brain. At therapeutically relevant concentrations, bivalent binding to TfR appears to reduce the transcytosis efficiency by receptor crosslinking. In this study, we aimed to improve BBB transcytosis of symmetric antibodies through minimizing their ability to cause TfR crosslinking. We created variants of the previously published RmAb158-scFv8D3, where the linker length between RmAb158 and the mTfR-targeting scFv8D3 was adjusted. We investigated the effect of the linker length on the antibodies’ binding kinetics to mTfR using ELISA and LigandTracer assays, and their ability to transcytose across BBB endothelial cells (In-Cell BBB-Trans assay). We show that even a direct fusion without a linker does not alter the antibodies’ apparent affinities to mTfR indicating their valency is unlikely affected by the linker length. However, the shortest linker variants demonstrated BBB transcytosis levels comparable to that of the monovalent control at a high antibody concentration and showed an almost two-fold higher level of BBB transcytosis compared to the longer-linker variants at the high concentration. Our new RmAb158-scFv8D3 short-linker variants are examples of symmetric, therapeutic antibodies with improved TfR-binding characteristics to facilitate more efficient brain uptake. We hypothesize that bivalent binding to TfR as such does not negatively affect BBB transcytosis in vitro, but a very short distance between TfR-targeting domains lowers the probability of receptor crosslinking. This study provides valuable insights into antibody-TfR interaction kinetics, contributing to future development of TfR-targeting antibody-based treatments for brain diseases.
Telemedicine-based exercise intervention in cancer survivors: a non-randomized controlled trial
Authors: Krell Verena , Porst Johanna , Hafermann Lorena , Kuhn Jessica , Greiß Franziska , Römer Claudia , Wolfarth Bernd 
Published: December 2024

AbstractCancer survivors (CS) often experience treatment-related side effects, such as fatigue, and have reduced physical function. Regular physical activity has been demonstrated to reduce these symptoms and improve cardiopulmonary fitness. Digital solutions are needed to optimize exercise options for CS in aftercare, especially given the significant limitations during the Covid-19 pandemic. This two-armed, non-randomized, controlled intervention study for CS aims to investigate whether a telemedicine-based exercise intervention is as effective as the current standard of care for oncological exercise therapy in aftercare. Patients in the intervention group (n = 61) performed a telemedicine-based exercise program (TE) and patients in the control group (n = 31) participated in an existing rehabilitation sports group (RG) over a six-month intervention period. The primary outcome was cardiopulmonary fitness measured by VO2peak; secondary outcomes included quality of life (QoL), fatigue, and physical activity. A non-inferiority analysis was performed with a predefined non-inferiority margin for relative VO2peak of -1.50 ml/min/kg. Although TE demonstrated a slight advantage in relative VO2peak compared to RG (adjusted mean difference of 0.55 ml/min/kg [95% CI: -2.74; 3.84]), the non-inferiority was not statistically significant. Nevertheless, the implementation of a telemedicine-based exercise intervention indicates that individual patients respond well to this type of exercise program and benefit from the intervention, particularly in terms of QoL. Finding an individualized program for each cancer survivor is the overarching goal. A telemedicine-based exercise intervention may be a promising option, particularly for younger patients.
Fortunate molecules boost signal to background ratio and localization precision in correlation based single molecule localization microscopy
Authors: S Aravinth , Zanacchi Francesca Cella , Mondal Partha Pratim 
Published: December 2024

AbstractSingle-molecule localization microscopy (SMLM) can decipher fine details that are otherwise impossible using diffraction-limited microscopy. Often, the reconstructed super-resolved images suffer from noise, strong background and are prone to false detections that may impact quantitative imaging. To overcome these limitations, we propose a technique (corrSMLM) that recognizes and detects fortunate molecules (molecules with long blinking cycles) from the recorded data. The method uses correlation between two or more consecutive frames to identify and isolate fortunate molecules that blink longer than the standard blinking period of a molecule. The corrSMLM is based on the fact that random fluctuations (noise) do not last longer (usually limited to a single frame). In contrast, fortunate molecules consistently fluoresce for extended periods and hence appear on more than one frame. Accordingly, strongly correlated spots (representing fortunate molecules) are compared in the consecutive frames, followed by data integration to determine their position and localization precision. The technique addresses two significant problems that plague existing SMLM : (1) false detection due to random noise that contributes to a strong background and (2) poor localization leading to overall low resolution. To demonstrate, corrSMLM is used for imaging fixed NIH3T3 cells (transfected with Dendra2-Actin, Dendra2-Tubulin, and mEos-Tom20 plasmid DNA). The super-resolved images show a significant reduction in background noise ( > 1.5 fold boost in SBR) and > 2-fold improvement in localization precision as compared to standard SMLM. Intensity analysis based on the number of molecules suggests that corrSMLM better corroborates the raw data and preserves finer features (e.g., edges), which are wiped out in standard SMLM. Overall, an improvement is noted in the localization precision and spatial resolution. The proposed technique is anticipated to advance SMLM and is expected to contribute to a better understanding of single-molecule dynamics in a cellular environment.
A CNN‐transformer‐based unsupervised aware hierarchical network for medical image registration
Authors: Fang Bo , Wang Lisheng 
Published: December 2024

AbstractMedical image registration is a fundamental and important technique in the field of medical image analysis. This study proposes a novel unsupervised end‐to‐end registration network, aiming to enable the model to actively acquire image features in the field of medical imaging with limited samples, which efficiently integrates multi‐scale features to achieve higher accuracy in registration. By utilizing region‐to‐region routing, this model actively preserves the most relevant features of the images, thereby improving training and learning efficiency. The model is evaluated by several publicly available datasets. The new network proposed in this study achieved the best registration accuracy among various advanced traditional and learning‐based methods.
High sensitivity multi‐channel digital receiver for wideband very weak signal direction‐finding classified by machine learning
Authors: Wu Chen , Low Michael 
Published: December 2024

AbstractFor weak signal detection with direction‐finding (DF), this article presents a new receiver design approach that combines our accumulatively increasing receiver sensitivity (AIRS) signal detection algorithm with the compressive‐sensing (CS)‐based DF‐array/algorithm. The former uses the concept of timeslot (TS)‐based signal threshold detection, whereas the latter employs a frequency‐independent array with randomly located elements, whose bandwidth (BW) largely determines the DF‐array BW. To estimate the direction of a signal, the AIRS algorithm generates the array steering vectors in each TS when the amplitude of any frequency bins exceeds the predetermined threshold of the TS. The aim of this paper is to demonstrate the ability of the new receiver to detect low probability of intercept radar signals with high DF accuracy, fine frequency resolution, and good time‐of‐arrival measurement resolution. To discriminate accurate emitter directions from many false estimations created by the DF‐array in very low signal‐to‐noise ratio environments, K‐means clustering was also applied. In a scenario, the frequency modulated signals from several 165‐mW X‐band radars were in the field of view of a 6‐element DF‐array. Simulation results show that the receiver can accurately estimate all the emitters' directions with root mean squared error of less than 1°, when the separation between the DF‐array and radars is about 100 km.
Low-frequency attenuation signal absorption performance of thin-film acoustic metamaterials
Authors: Xu Jingcheng , Chen Changzheng 
Published: December 2024

Considering that thin film acoustic metamaterials have many special properties that natural materials and traditional materials do not possess, the low-frequency attenuation signal absorption performance of thin film acoustic metamaterials is studied. Prepare thin film acoustic metamaterials using raw materials such as silicone, calculate the basic law of low-frequency attenuation signal absorption based on this material, and determine the acoustic parameters of thin film acoustic metamaterials through calculation. Using the obtained acoustic parameters as inputs, a finite element numerical model of thin film acoustic metamaterials is used to analyze the low-frequency attenuation signal absorption performance under changes in porosity, thickness, density, size, tension, parameter error, and frame material and mass width in contact area with the thin film. The experimental results show that when the porosity is 95%, the thickness is 11, the variable length is 16 mm, the tension force is 160 N/m, and the contact area between the mass block and the film is 5.5 mm2, the absorption effect of low-frequency attenuation signals is the best. The frame material and elastic modulus have little effect on the absorption performance of the thin film acoustic material.
Human Milk-Derived Fortifier to Reduce Hospital-Acquired Malnutrition in Uncomplicated Gastroschisis: A Case Report
Authors: Strle Anna , Reyes Sarah M. , Schmidt Megan , Lynch Mary Frances 
Published: December 2024

AbstractGastroschisis is one of the most common congenital gastrointestinal disorders, occurring in about one in 1,953 infants born each year in the United States. Infants with gastroschisis rely on total parenteral nutrition (TPN) preoperatively, and due to intestinal function and dysmotility issues, continue to face feeding challenges postclosure, including feeding intolerance and increased risk of necrotizing enterocolitis (NEC). Postclosure, human milk-feeding is preferred over infant formula because of its associated reduced risk of feeding intolerance and NEC. However, unfortified human milk often falls short of meeting the increased metabolic demands of these postsurgical infants in the first few weeks of life, leading to hospital-acquired malnutrition (undernutrition) as TPN is weaned. We hypothesized that fortifying maternal milk with human milk-based fortifiers would mitigate the risk of hospital-acquired malnutrition while providing the tolerance benefits of an exclusive human milk diet, specifically by meeting the increased energy and protein demands of the immediate postsurgical infant as parenteral nutrition is weaned. The case report describes our unit's use of a human milk-based fortifier in an infant with uncomplicated gastroschisis and its positive effect on the patient's growth. Further research is warranted to assess the use of human milk-derived fortifiers to prevent hospital-acquired malnutrition after gastrointestinal surgery.
La versión en español del QuickDASH: Fiabilidad, error de medición, validez de constructo y sensibilidad para la evaluación de resultados en el Síndrome del Túnel Carpiano.
Authors: Rosales Roberto S. , Sambad-Rodriguez Hugo , Menaya-Fernandez Carmen , Martin-Hidalgo Yolanda , Reboso-Morales Luis 
Published: December 2024

Resumen
Objetivo El propósito de este artículo fue evaluar la confiabilidad, el error de medición, la validez de construcción y la respuesta de la versión española del QuickDASH para la evaluación de resultados en el síndrome del túnel carpiano (STC).
Métodos Una población total de 40 pacientes con diagnóstico de STC completó las versiones en español del QuickDASH, CTS-AL y EQ-5D una semana antes de la cirugía, el día previo a la cirugía y tres meses después de la intervención. La consistencia interna fue analizada mediante el coeficiente α de Cronbach. Para evaluar la concordancia absoluta se utilizaron el coeficiente de correlación intraclase (ICC2,1), el coeficiente de correlación de Lin (CCC) y el límite de acuerdo de Bland y Altman (LoA), mientras que el método no paramétrico de Passing-Bablok (P-B) se empleó para evaluar el sesgo sistemático constante y/o proporcional entre las mediciones. La precisión transversal se analizó con el error estándar de medición (SEM). La precisión longitudinal para el coeficiente de fiabilidad test-retest se analizó con el error estándar de la diferencia de medición (SEMdiff) y el cambio mínimo detectable al 90 % (MDC90) y al 95 % (MDC95) de nivel de confianza. Para evaluar la validez de construcción, se formuló la hipótesis de que el QuickDASH tendría una fuerte correlación positiva con el CTS-AL y una correlación negativa moderada con el índice EQ-5D, utilizando el coeficiente de correlación de Pearson (r) con un nivel de significancia de 0.05.
Resultados El coeficiente de Cronbach fue de 0.912. ICC2,1 y CCC mostraron una concordancia absoluta alta (0.868 y 0.738 respectivamente). La regresión P-B no mostró diferencias constantes y proporcionales significativas entre las dos administraciones del QuickDASH. El QuickDASH mostró una respuesta (ES = 2.1; SRM = 1.97) inferior al CTS-AL (ES = 3.53; SRM = 3.50) y superior al índice EQ-5D (ES = 0.78; SRM = 0.83).
Conclusión La versión española (España) del instrumento QuickDASH presentó buen nivel de confiabilidad, validez de construcción y respuesta para la evaluación de resultados en STC.
Borescopes as a Training Tool for Neuroendoscopy
Authors: Bakhsh Aman , Bajaj Jitin , Yadav Mansi , Patidar Jayant , Ratre Shailendra , Parihar Vijay S. , Yadav Yad R. 
Published: December 2024

Abstract
Background Neuroendoscopy is increasingly utilized as a minimally invasive method. Due to its challenging learning process, there is a pressing need for cost-efficient training methods for residents and fellows in these surgeries. One such modality is using borescopes as substitutes for endoscopes, which could prove beneficial in resource-limited settings. However, existing literature on the use of borescopes in surgical practice for training remains scarce.
Methods A thorough literature review was conducted to assess the applicability of borescopes. The search encompassed original articles, review articles, and randomized control trials on PubMed and Cochrane library. Studies were analyzed to evaluate the operability and limitations of borescopes in medical settings, considering factors such as light source, water resistance, sterility, camera quality, rigidity, ease of operation, and cost. This review also draws on practical experience using borescopes in endoscopic training, supplemented by feedback from neuroendoscopic fellows and consultants who have participated in our biannual workshops since March 2022.
Results The literature search yielded 522 articles, which, after applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulted in 61 studies meeting the inclusion criteria. Universal serial bus (USB) powered borescopes have been employed as substitutes for endoscopes in training models using practice models and cadavers, facilitating the study of neuroanatomy and aiding in airway visualization during laryngoscopy. Despite lower resolution and fidelity compared to traditional endoscopy towers, their versatility and enhanced functionality through attachments make them an affordable alternative for endoscopes, contributing to improved surgical proficiency.
Conclusion Borescopes have demonstrated potential as substitutes for endoscopes in training models, with positive feedback from trial participants suggesting broader applications in practice settings and possibly even clinics. This could ultimately enhance accessibility to endoscopic surgery, particularly in underserved regions.
Reparación artroscopica de anclaje con tornillo de sutura de desgarros del complejo de fibrocartílago triangular del lado radial: Una técnica quirúrgica novedosa
Authors: Ayik Ömer , Paksoy Ahmet Emre 
Published: December 2024

ResumenLas roturas radiales (tipo 1d) son las lesiones del complejo del fibrocartílago triangular (TFCC) menos frecuentes. Los síntomas se presentan como dolor y limitación funcional de la muñeca. Presentamos el caso de un varón de 23 años que presentaba rotura radial del TFCC con síntomas tras una caída 6 meses antes. Tras el estudio adecuado, se trató mediante reparación artroscópica con un anclaje de tornillo con sutura. Estos tipos de roturas, que antes se reparaban con métodos abiertos, posteriormente se repararon a través del túnel transóseo abierto en el radio con asistencia artroscópica. Las técnicas descritas posteriormente hicieron modificaciones menores para formar el túnel más fácilmente. La técnica descrita en el presenta estudio puede ser un método alternativo en rupturas del lado radial del TFCC debido a algunas ventajas que proporciona en comparación con las técnicas de perforación previamente descritas
What Challenges for Global Development Research are Posed by a More Decolonial Approach? Colonial Genealogies and Responses
Authors: Camfield Laura 
Published: December 2024

AbstractThe increasing appetite for decolonial approaches in development research challenges conventional methodologies rooted in colonial legacies. While the relationship between colonialism and development is well documented, the colonial underpinnings of key research methods, such as surveys and big data, have received less attention. This paper critically examines how these methods, as tools of colonial governance, continue to predominate in development research and reduce the space for decolonial alternatives. It highlights the continuities between colonial-era data practices, such as population censuses, and contemporary methods like big data, arguing that they can perpetuate power asymmetries and “data colonialism”. In contrast, decolonial methodologies emphasise reflexivity, relationality, and the active participation of indigenous communities. However, there is potential for these methods to be co-opted or instrumentalized within the global development research ecosystem, if they are adopted without a critical understanding of the relationship between power and knowledge. This paper evaluates emerging decolonial alternatives, including methodologies grounded in indigenous knowledge systems and ethical frameworks such as Ubuntu and relationality, assessing their potential to resist such co-option. The paper concludes by arguing that while decolonial research offers a more holistic and ethically grounded alternative to conventional methods, its influence is limited by the persistence of deeper structural inequities. These include the dominance of Northern epistemologies and the commodification of research methods and expertise within academia. Future development research must not only adopt decolonial approaches but also actively deconstruct the existing power dynamics within the field to create equitable and inclusive knowledge systems.
Study of the N2 vibrational relaxation behaviors via the CO rovibrational thermometry
Authors: He Dong , Liu Tielou , Li Renjie , Hong Qizhen , Li Fei , Sun Quanhua , Si Ting , Luo Xisheng 
Published: December 2024

This paper performed a comprehensive study of the thermal nonequilibrium effects of CO/Ar mixtures with various degrees of N2 additions and probed the N2 relaxation behaviors via the CO rovibrational thermometry. The rovibrational temperature time histories of shock-heated CO/N2/Ar mixtures were measured via a laser-absorption technique, and the corresponding vibrational relaxation data were summarized at 1890–3490 K. The measured results were compared with predictions from the Schwartz–Slawsky–Herzfeld (SSH) formula and the state-to-state (StS) approach (treating CO and N2 as pseudo-species). The vibrational state-specific inelastic rate coefficients for N2–N2 collisions were supplemented using the mixed quantum–classical calculations. The StS predictions, informed by experimentally measured pressures, showed good agreement with experimental data. Additionally, the impact of coupling between flow dynamics and StS kinetics behind reflected shock waves was evaluated using two different one-dimensional approaches, which provide limiting bounds (accounting for unsteady flow and end wall effects) in post-reflected shock flow conditions. Moreover, the vibrational relaxation data of the N2–N2 system were modified via sensitivity analysis to improve the performance of the SSH formula. Further analysis highlighted that the vibration–vibration–translation path provides an efficient way for vibrational energy transfer between CO and N2, resulting in almost the same vibrational temperature time histories for CO and N2. Therefore, the N2 relaxation behaviors can be characterized by the CO rovibrational thermometry, considering N2 is infrared inactive. Finally, the heat sink effects and the reflected-shock-bifurcation phenomena were highlighted.
Short-time collective dynamics of an ionic liquid: A computer simulation study with non-polarizable and polarizable models, and ab initio molecular dynamics
Authors: Paschoal Vitor Hugo , Ribeiro Mauro C. C. 
Published: December 2024

Molecular dynamics (MD) simulation is used to study the intermolecular dynamics in the THz frequency range of the ionic liquid 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide, [C2C1im][FSI]. Non-polarizable and polarizable models for classical MD simulation are compared using as quality criteria ab initio molecular dynamics (AIMD) and experimental data from far-infrared (FIR) spectroscopy and previously published data of inelastic x-ray scattering (IXS). According to data from IXS spectroscopy, incorporating polarization in the classical MD simulation has relatively little effect on the dispersion curve (excitation frequency vs wavevector) for longitudinal acoustic modes. When the AIMD simulation is used as a reference, the polarizable model leads the time correlation functions of velocity, mass, and charge currents to relax abnormally quickly. The charge current spectra from the AIMD simulation and the non-polarizable model agree with the experimental FIR spectrum, while the polarizable model gives an excessively broad band. When compared to the non-polarizable model, the polarizable model does improve the calculation of transport coefficients (diffusion coefficient, viscosity, and conductivity); however, it yields overdamped short-time collective dynamics.