bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR‐214
Authors: Wang Liuzhong , Sang Jianzhong , Zhang Yamin , Gao Ling , Zhao Dongli , Cao Hua 
Published: October 2021

AbstractBackgroundCircular RNA itchy E3 ubiquitin protein ligase (circ‐ITCH) has previously been reported to play a key role in carcinogenesis. Nevertheless, the role of circ‐ITCH in nasopharyngeal carcinoma (NPC) remains to be explored.MethodsGene expression analysis was performed using a quantitative real‐time polymerase chain reaction, western blotting and immunohistochemistry. The role of circ‐ITCH in NPC was explored using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide, colony formation, transwell invasion, scratch healing and xenograft tumor assays. Furthermore, luciferase reporter assay was carried out to assess the interactions among circ‐ITCH, microRNA‐214 (miR‐214) and phosphatase and tensin homolog (PTEN).ResultsThe levels of circ‐ITCH and PTEN were decreased, whereas the level of miR‐214 was increased in NPC tissues collected from 28 subjects compared to normal nasopharynx tissues collected from 15 subjects. Moreover, a negative correlation between circ‐ITCH and miR‐214 expression and a positive correlation between circ‐ITCH and PTEN expression were observed in NPC tissues. Downregulation of circ‐ITCH expression was also observed in NPC cell lines. In addition, upregulation of circ‐ITCH markedly inhibited NPC cell proliferation, migration and invasion. Furthermore, circ‐ITCH was confirmed to exert its function by sponging miR‐214. PTEN was found to be a direct target gene of miR‐214 and its expression was negatively correlated with miR‐214 expression in NPC tissues. Moreover, our results showed that the circ‐ITCH/miR‐214 axis regulated NPC proliferation, migration and invasion through regulating the expression of PTEN. Upregulation of circ‐ITCH or PTEN blocked miR‐214‐mediated promotion of NPC tumorigenesis in vitro. Additionally, upregulation of circ‐ITCH also suppressed NPC tumorigenesis in vivo.ConclusionsThe present study demonstrated that circ‐ITCH suppressed NPC tumorigenesis by upregulating PTEN expression through interacting with miR‐214, thus proposing a novel mechanism for NPC inhibition.
Cass's Homosexual Identity Formation: A Critical Analysis
Authors: Goodrich Kristopher M. , Brammer M. Kathryn 
Published: October 2021

Cass's (1979) model of homosexual identity formation has been used as a guideline to understand sexual identity development, although questions of its current applicability have been raised. This article critically analyzes Cass's model through a contemporary lens. To contextualize and understand the model and its implications, we review empirical and anecdotal research, as well as several human processes. Implications for counselors and counselor educators and suggestions for best use of the model are provided.El modelo de formación de la identidad homosexual de Cass (1979) ha sido utilizado como una guía para comprender el desarrollo de la identidad sexual, aunque han surgido dudas sobre su validez en la actualidad. Este artículo analiza de forma crítica el modelo de Cass desde una perspectiva contemporánea. Para contextualizar y comprender el modelo y sus implicaciones, revisamos las investigaciones empíricas y anecdóticas, además de varios procesos humanos. Se proporcionan implicaciones para consejeros y educadores en consejería, así como sugerencias sobre la mejor forma de utilizar el modelo.
Linking Creativity to Psychological Well‐being: Integrative Insights from the Instrumental Emotion Regulation Theory
Authors: Leung Angela K.‐y. , Koh Brandon , Phang Riyang , Lee Sean T. H. , Huang Tengjiao 
Published: October 2021

AbstractResearch has recognized that people regulate their emotions not only for seeking pleasurable experiences but also for receiving instrumental gains. We draw on the theoretical framework of instrumental emotion regulation (IER; Tamir, 2005, 2009) to shed new light on the relationships among creativity, emotion, and psychological well‐being. We outline propositions that explain why there are concurrent creative and well‐being benefits when people experience emotional states that are consistent with their personality trait (e.g., worrisome emotions being consistent with trait neuroticism) even if such trait‐consistent emotions are negative. The IER perspective offers new interpretations of the creativity—well‐being relationship through motivating a more holistic view of emotion regulation and well‐being. We present an integrative theoretical model explicating that instrumental regulation toward trait‐consistent emotions engages people in emotional states that feel affectively right (affective path), motivate them intrinsically (motivational path), and boost cognitive efficiency (cognitive path), thus yielding potential downstream benefits on creativity and well‐being.
Crosslinking Trends in Multicomponent Hydrogels for Biomedical Applications
Authors: Dodda Jagan Mohan , Azar Mina Ghafouri , Sadiku Rotimi 
Published: October 2021

AbstractMulticomponent‐based hydrogels are well established candidates for biomedical applications. However, certain aspects of multicomponent systems, e.g., crosslinking, structural binding, network formation, proteins/drug incorporation, etc., are challenging aspects to modern biomedical research. The types of crosslinking and network formation are crucial for the effective combination of multiple component systems. The creation of a complex system in the overall structure and the crosslinking efficiency of different polymeric chains in an organized fashion are crucially important, especially when the materials are for biomedical applications. Therefore, the engineering of hydrogel has to be, succinctly understood, carefully formulated, and expertly designed. The different crosslinking methods in use, hydrogen bonding, electrostatic interaction, coordination bonding, and self‐assembly. The formations of double, triple, and multiple networks, are well established. A systematic study of the crosslinking mechanisms in multicomponent systems, in terms of the crosslinking types, network formation, intramolecular bonds between different structural units, and their potentials for biomedical applications, is lacking and therefore, these aspects require investigations. To this end, the present review, focuses on the recent advances in areas of the physical, chemical, and enzymatic crosslinking methods that are often, employed for the designing of multicomponent hydrogels.
Ethylene/Propylene/Diene Terpolymers Grafted with Poly(methyl acrylate) by Reverse Atom Transfer Radical Polymerization
Authors: Rostami Najafabadi Zahra , Omaña Alvaro A. , Rivard Eric , Soares João B. P. 
Published: October 2021

AbstractThis article describes the synthesis of ethylene‐propylene‐diene terpolymers grafted with poly(methyl acrylate) (PMA) by reverse atom transfer radical polymerization. The PMA graft molecular weights and densities are controlled by varying the concentration and conversion of methyl acrylate, as well as the concentration of initiator. The grafted copolymers are characterized by Fourier‐transform infrared spectroscopy, proton NMR, and gel permeation chromatography. Copolymers with graft molecular weights varying from 12 to 179 kDa and grafting densities from 11% to 53% are made following this procedure.
Consumer cynicism in service failures
Authors: Tran Hai‐Anh , Strizhakova Yuliya , Usrey Bryan , Johnson Samuel 
Published: October 2021

AbstractDespite growing corporate commitments to being customer‐centric, many customers perceive firms as self‐driven and caring only about their own business interests. This sentiment is projected in consumer cynicism, or negative consumer attitudes based on the disbelief in the sincerity of firms' motives and actions. We argue that consumer cynicism emerges in response to negative marketplace situations, such as service and product failures. Across four scenario‐based experiments and one video‐based experiment, our research examines cynicism as a key mediator, transmitting the effect of double deviation (i.e., a failure in delivery and in subsequent recovery) on negative electronic word‐of‐mouth and repurchase intention. We further demonstrate that consumer cynicism can be minimized when the provider uses cocreated recovery (i.e., engages consumers in recovery) even if the recovery fails and when the provider offers a strong empathetic apology (either before or after recovery failure). Our research contributes to consumer and service recovery research by highlighting an important but overlooked role of consumer cynicism in the context of double deviation. We also offer managerial insights into cocreation and empathetic apologies as cost‐effective recovery strategies to minimize cynicism.
Accumulation of Sulfonic Acid Groups Anchored in Covalent Organic Frameworks as an Intrinsic Proton‐Conducting Electrolyte
Authors: Zhai Lipeng , Yao Yuze , Ma Baiwei , Hasan Md. Mahmudul , Han Yuxi , Mi Liwei , Nagao Yuki , Li Zhongping 
Published: October 2021

AbstractCovalent organic frameworks (COFs) are a novel class of crystalline porous polymers, which possess high porosity, excellent stability, and regular nanochannels. 2D COFs provide a 1D nanochannel to form the proton transport channels. The abovementioned features afford a powerful potential platform for designing materials as proton transportation carriers. Herein, the authors incorporate sulfonic acid groups on the pore walls as proton sources for enhancing proton transport conductivity in the 1D channel. Interestingly, the sulfonic acid COFs (S‐COFs) electrolytes being binder free exhibit excellent proton conductivity of ≈1.5 × 10−2 S cm−1 at 25 ℃ and 95% relative humidity (RH), which rank the excellent performance in standard proton‐conducting electrolytes. The S‐COFs electrolytes keep the high proton conduction over the 24 h. The activation energy is estimated to be as low as 0.17 eV, which is much lower than most reported COFs. This research opens a new window to evolve great potential of structural design for COFs as the high proton‐conducting electrolytes.
Pilot tone navigation for respiratory and cardiac motion‐resolved free‐running 5D flow MRI
Authors: Falcão Mariana B. L. , Di Sopra Lorenzo , Ma Liliana , Bacher Mario , Yerly Jérôme , Speier Peter , Rutz Tobias , Prša Milan , Markl Michael , Stuber Matthias , Roy Christopher W. 
Published: October 2021

PurposeIn this work, we integrated the pilot tone (PT) navigation system into a reconstruction framework for respiratory and cardiac motion‐resolved 5D flow. We tested the hypotheses that PT would provide equivalent respiratory curves, cardiac triggers, and corresponding flow measurements to a previously established self‐gating (SG) technique while being independent from changes to the acquisition parameters.MethodsFifteen volunteers and 9 patients were scanned with a free‐running 5D flow sequence, with PT integrated. Respiratory curves and cardiac triggers from PT and SG were compared across all subjects. Flow measurements from 5D flow reconstructions using both PT and SG were compared to each other and to a reference electrocardiogram‐gated and respiratory triggered 4D flow acquisition. Radial trajectories with variable readouts per interleave were also tested in 1 subject to compare cardiac trigger quality between PT and SG.ResultsThe correlation between PT and SG respiratory curves were 0.95 ± 0.06 for volunteers and 0.95 ± 0.04 for patients. Heartbeat duration measurements in volunteers and patients showed a bias to electrocardiogram measurements of, respectively, 0.16 ± 64.94 ms and 0.01 ± 39.29 ms for PT versus electrocardiogram and of 0.24 ± 63.68 ms and 0.09 ± 32.79 ms for SG versus electrocardiogram. No significant differences were reported for the flow measurements between 5D flow PT and from 5D flow SG. A decrease in the cardiac triggering quality of SG was observed for increasing readouts per interleave, whereas PT quality remained constant.ConclusionPT has been successfully integrated in 5D flow MRI and has shown equivalent results to the previously described 5D flow SG technique, while being completely acquisition‐independent.
A nursing mentoring programme on non‐pharmacological interventions against BPSD: Effectiveness and use of antipsychotics—A retrospective, before–after study
Authors: Plante‐Lepage Roxane , Voyer Philippe , Carmichael Pierre‐Hugues , Kröger Edeltraut 
Published: October 2021

AbstractBehavioural and psychological symptoms of dementia (BPSD) are common and have significant implications for patients and caregivers. Non‐pharmacological interventions (NPI) have shown to be effective in the management of BPSD. However, the use of antipsychotics to treat BPSD remains ubiquitous. This retrospective, before–after study aimed to examine whether a nurse mentoring programme promoting NPI for BPSD management had a significant association with the use of antipsychotics in older adults with major neurocognitive disorders residing in different settings. Results obtained from the medical files of 134 older adults having benefitted from the mentoring programme demonstrate that this intervention significantly reduced BPSD. The effect on antipsychotics use was modest: a 10% reduction in the use of antipsychotics has been observed among patients for which the NPI were effective. However, the use of antipsychotics remained widespread despite the nursing recommendations of the mentoring team of the Center of Excellence on Aging in Quebec (CEVQ).
Processable and recyclable polyurethane/HNTs@Fe3O4 solid–solid phase change materials with excellent thermal conductivity for thermal energy storage
Authors: Lin Changhong , Ying Puyou , Huang Min , Zhang Ping , Yang Tao , Liu Gang , Wu Jianbo , Levchenko Vladimir 
Published: October 2021

AbstractThe permanently chemically cross‐linking solid–solid phase change materials (SSPCMs) were designed to solve the problem of leakage and poor shape stability during the whole process of phase transformation. However, these materials lead to environment pollution and resources waste because of the non‐recyclability. Therefore, a SSPCMs was fabricated using dynamic thermal reversible Diels–Alder bonds. The prepared SSPCMs exhibited excellent shape, heat storage stability, and reliability and reprocessed ability, resulting from dynamic Diels–Alder bonds. Moreover, the Halloysite nanotubes decorated with Fe3O4 nanoparticles (HNTs@Fe3O4) were used to enhance the thermal conductivity of SSPCMs. When the filler content was 0.5 wt%, the best integrated properties (phase change properties and thermal conductivity) of the SSPCMs were obtained, it had the highest melting and freezing phase change enthalpies about 116.8 and 127.2 J/g, and thermal conductivity value, 0.223 W/m K, which was 101% higher than pure SSPCMs. Hence, the prepared SSPCMs can be considered as promising save‐energy, friendly‐environment thermal management materials.
Pharmacological and epidemiological considerations while constructing treatment episodes using observational data: A simulation study
Authors: Pazzagli Laura , Andersen Morten , Sessa Maurizio 
Published: October 2021

AbstractBackgroundThe permissible gap method is an extensively used approach for defining episodes of continuous treatment use in pharmacoepidemiology. This method uses the amount of drug redeemed, when available, and researcher‐defined temporal gaps to fill the interval between the calculated end of coverage of a redeemed prescription and the date of redemption of the next prescription in the same treatment episode. The final scope is defining periods of continuous use of medications. There are strong pharmacological and epidemiological arguments for adding the gap at the end of each treatment episode. However, the evidence is scarce on the impact that such a practice has on measures of association. This study aims to compare the impact of adding or not adding the researcher‐defined gap time to the end of a treatment episode on the incidence of drug discontinuation and the incidence rate for a simulated outcome that occurred during an observational window. Additionally, the study aims at assessing the magnitude of misclassification of exposure time between the two methods.MethodsA simulated dataset of 100 patients available in the R package AdhereR that contains 1080 redeemed prescriptions was used. A gap time of 90 days was used for constructing treatment episodes in an observational window of 365 days following the first redeemed prescription. Two approaches were used for defining treatment episodes that were named “gap+” and “gap–” and that respectively add and did not add the gap time at the end of a treatment episode. An outcome was simulated by using an exponential baseline hazard function with scale parameter λ = 0.5 and censoring at time t = 365 days. The incidence rate ratio for the simulated outcome between the two approaches was computed.ResultsThe 100 patients were followed for a median time of 183 days (interquartile range, IQR 50–365 days) and a median time of 273 days (IQR 140–365 days), respectively using “gap–” and “gap+”. During the first 100 days of the follow‐up period, none of the patients was found to discontinue the treatment with the method “gap+” while 38 patients discontinued using the method “gap–”. The approach “gap+” exerted a higher incidence rate for the simulated outcome among the exposed (0.98 events/person‐years) when compared to the “gap–” (0.82 events/person‐years) during defined periods of continuous treatment use. When comparing the two approaches and using the method “gap–” as the reference group, the incidence rate ratio for the simulated outcome was 1.20 (95% confidence interval: CI 0.72–2.02) among the exposed.ConclusionsThis study showed that not adding the gap at the end of the treatment episodes leads to an overestimation of drug discontinuation, particularly at the beginning of the observational window, and an underestimation of the incidence rate of a hypothetical outcome during the period of exposure to the medication.
Respiratory syncytial virus bronchiolitis in congenital diaphragmatic hernia: A systematic review of prevalence rates and palivizumab prophylaxis
Authors: Lewis Leonie , Sinha Ian , Losty Paul D 
Published: October 2021

AbstractBackgroundThe seasonality of respiratory syncytial virus (RSV) epidemics have been disrupted during the COVID‐19 pandemic, possibly because of lockdowns and social restrictions reducing viral transmission. Given uncertainties around the severity of upcoming RSV bronchiolitis epidemics, debate exists whether palivizumab (RSV prophylaxis) should be administered to infants with Congenital Diaphragmatic Hernia (CDH), who may be vulnerable due to lung hypoplasia and pulmonary hypertension.AimTo evaluate (1) if CDH infants have higher risk of admission with RSV bronchiolitis than infants in the general population; (2) if palivizumab prophylaxis may reduce this risk.MethodsWe included all eligible studies examining the risk(s) of RSV‐positive bronchiolitis requiring hospital admission in (1) CDH infants without palivizumab prophylaxis versus infants in the general population and (2) CDH infants with prophylaxis versus CDH infants without prophylaxis. The primary outcome evaluated was the risk of admission with RSV bronchiolitis. Data are reported descriptively and meta‐analysed when appropriate.ResultsThree eligible retrospective cohort studies were identified: one study found CDH to be an independent risk factor for RSV hospitalisation (odds ratio, 3.30; 95% confidence interval [CI], 2.01–4.4); two studies compared RSV hospitalisation rates in CDH patients who had palivizumab versus those that did not. The pooled risk ratio was 1.11 (95% CI, 0.29–4.23; p = .88). Overall, the quality of evidence was considered poor and one study was industry funded.ConclusionWhether CDH infants are at particular risk of severe bronchiolitis remains unclear. There is no evidence from this current systematic review that CDH infants should routinely receive palivizumab vaccination prophylaxis.
Conformational variability in proteins bound to single‐stranded DNA: A new benchmark for new docking perspectives
Authors: Mias‐Lucquin Dominique , Chauvot de Beauchene Isaure 
Published: October 2021

AbstractWe explored the Protein Data Bank (PDB) to collect protein–ssDNA structures and create a multi‐conformational docking benchmark including both bound and unbound protein structures. Due to ssDNA high flexibility when not bound, no ssDNA unbound structure is included in the benchmark. For the 91 sequence‐identity groups identified as bound–unbound structures of the same protein, we studied the conformational changes in the protein induced by the ssDNA binding. Moreover, based on several bound or unbound protein structures in some groups, we also assessed the intrinsic conformational variability in either bound or unbound conditions and compared it to the supposedly binding‐induced modifications. To illustrate a use case of this benchmark, we performed docking experiments using ATTRACT docking software. This benchmark is, to our knowledge, the first one made to peruse available structures of ssDNA–protein interactions to such an extent, aiming to improve computational docking tools dedicated to this kind of molecular interactions.
What do relationships between extractable metals and soil organic carbon concentrations mean?
Authors: Hall Steven J. , Thompson Aaron 
Published: October 2021

AbstractAluminum (Al)‐bearing and iron (Fe)‐bearing minerals, especially short‐range‐ordered (SRO) phases, are thought to protect soil organic C (SOC). However, it remains methodologically challenging to assess the influence of Al vs. Fe minerals or metal complexes. Whereas SRO Al and Fe phases share some properties, Al dissolved by oxalate (Alox) often correlates stronger with SOC than Fe dissolved by oxalate (Feox) or citrate–dithionite (Fecd). To further evaluate these relationships, we analyzed a large North American soil dataset from the National Ecological Observatory Network. A strong relationship between Alox and SOC (and weaker Feox‐SOC relationship) persisted even after excluding soils rich in SRO minerals (Andisols and Spodosols). Al dissolved by oxalate was strongly correlated with citrate–dithionite‐extractable Al (Alcd; slope = 0.92, R2 = .69), and discrepancies could be explained (R2 = .87) by greater dissolution of Al‐substituted Fe phases by citrate–dithionite and greater dissolution of aluminosilicates by oxalate. Aluminum dissolved by oxalate and Alcd were both strong SOC predictors despite their differing relationships with silicon (Si). Al dissolved by oxalate and Siox strongly covaried (R2 = .79), but Alcd was inconsistently related to Sicd (R2 = .18). Similar relationships of Alox and Alcd with SOC, despite differences in minerals extracted by oxalate and citrate–dithionite, suggest that Al‐OC complexes (as opposed to aluminosilicate or iron‐bearing minerals) were the best SOC predictor. This raises important questions: do Al‐OC complexes indicate protection from decomposition or simply reflect greater intensity of mineral weathering by organic acids; and, if the latter, then perhaps SOC input is driving Alox and SOC correlations rather than Al phase composition or abundance.