bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal Stem Cell Therapy for Acetaminophen-related Liver Injury:
A Systematic Review and Meta-analysis of Experimental Studies In
Vivo
Authors: Zhou Shuisheng , Xu Chengfang , Wang Li , Zhang Yiwen , Zhong Jiajun , Zhang Yuan 
Published: October 2021

Objective:
The efficacy of mesenchymal stem cell (MSC) therapy in acetaminophen-induced
liver injury has been investigated in animal experiments, but individual studies with a small
sample size cannot be used to draw a clear conclusion. Therefore, we conducted a systematic review
and meta-analysis of preclinical studies to explore the potential of using MSCs in acetaminophen-
induced liver injury.

Methods:
Eight databases were searched for studies reporting the effects of MSCs on acetaminophen
hepatoxicity. The Preferred Reporting Items for Systematic Reviews and Meta-analyses
(PRISMA) guidelines were used. SYRCLE’s risk of bias tool for animal studies was applied to
assess the methodological quality. A meta-analysis was performed by using RevMan 5.4 and STATA/
SE 16.0 software.

Results:
Eleven studies involving 159 animals were included according to PRISMA statement
guidelines. Significant associations were found for MSCs with the levels of alanine transaminase
(ALT) (standardized mean difference (SMD) - 2.58, p < 0.0001), aspartate aminotransferase (AST)
(SMD - 1.75, p = 0.001), glutathione (GSH) (SMD 3.7, p < 0.0001), superoxide dismutase (SOD)
(SMD 1.86, p = 0.022), interleukin 10 (IL-10) (SMD 5.14, p = 0.0002) and tumor necrosis factor-α
(TNF-α) (SMD - 4.48, p = 0.011) compared with those in the control group. The subgroup analysis
showed that the tissue source of MSCs significantly affected the therapeutic efficacy (p < 0.05).

Conclusion:
Our meta-analysis results demonstrate that MSCs could be a potential treatment for acetaminophen-
related liver injury. The protocol for this meta-analysis was prospectively registered
in PROSPERO (Number: CRD42020212677).
BDselect: A Package for k-mer Selection Based on the Binomial Distribution
Authors: Dao Fu-Ying , Lv Hao , Zhang Zhao-Yue , Lin Hao 
Published: October 2021

Background:
Dimension disaster is often associated with feature extraction. The extracted
features may contain more redundant feature information, which leads to the limitation of computing
ability and overfitting problems.

Objective:
Feature selection is an important strategy to overcome the problems from dimension disaster.
In most machine learning tasks, features determine the upper limit of the model performance. Therefore,
more and more feature selection methods should be developed to optimize redundant features.

Methods:
In this paper, we introduce a new technique to optimize sequence features based on the binomial
distribution (BD). Firstly, the principle of the binomial distribution algorithm is introduced in detail.
Then, the proposed algorithm is compared with other commonly used feature selection methods on
three different types of datasets by using a Random Forest classifier with the same parameters.

Results:
The results confirm that BD has a promising improvement in feature selection and classification
accuracy.

Conclusion:
Finally, we provide the source code and executable program package (http: //lingroup.
cn/server/BDselect/), by which users can easily perform our algorithm in their researches.
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with
Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded
Randomized Clinical Trial
Authors: Aminnejad Reza , Hormati Ahmad , Shafiee Hamed , Alemi Faezeh , Hormati Maryam , Saeidi Mohammad , Ahmadpour Sajjad , Sabouri Seyed Mahdi , Aghaali Mohammad 
Published: October 2021

Background:
In this double-blinded randomized clinical trial, we aimed to compare the
safety and efficacy of a combination of dexmedetomidine and ketamine (DK) with propofol and
fentanyl (PF) for sedation in colonoscopy patients.

Methods:
In this study, 64 patients who underwent colonoscopy were randomized into two groups:
1) A, which received PF, and 2) B, which received DK for sedation. Among 64 patients, 31 patients
were included in PF, and 33 patients were included in the DK group. Both groups were similar
in terms of demographics. Patients’ sedation score (based on Ramsay sedation scale) and vital
signs were recorded at 2, 5, 10, and 15 minutes. Complications including apnea, hypotension, hypoxia,
nausea, and vomiting, along with gastroenterologist satisfaction and patients’ pain score
(based on Wong-Baker faces pain assessment scale), were recorded by a checklist. Data were analyzed
by SPSS v.18 software, using chi-square, independent t-tests, and repeated measures analysis
with p<0.05 as the criterion for significant differences.

Results:
The mean score of sedation was 4.82±0.49 in the DK group and 5.22±0.45 in the PF
group (p value=0.001). Serious complications, including hypotension (p value=0.005) and apnea
(p value=0.10) were significantly higher in the PF group. Satisfaction of gastroenterologist (p value=
0.400) and patients’ pain score (p value = 0.900) were similar among groups.

Conclusion:
Combination of DK provides sufficient sedation with fewer complications in comparison
with PF in colonoscopy patients.

Clinical Trial Registration No:
The study was also registered at the Iranian Center for Clinical
Trials (No. IRCT20161205031252N11).
Nonimaging Optical Design with Supporting Quadric Method and Deep
Neural Network
Authors: Zhang Hang , Ma Peifu , Chen Jiawen , Hu Yuejiao , Shou Huahao 
Published: October 2021

Background:
The supporting quadric method(SQM) is a versatile method for designing
freeform optics for desired irradiance redistribution, but the time of solution optimization increases
rapidly with the refinement of the mapping grid.

Objective:
As the complexity of light distribution is getting higher and higher, time consumed will
also increase exponentially. This paper proposes an idea of applying the deep neural network method
to optical design.

Methods:
In this article, we established a special corresponding relationship and prepared a dataset,
which underwent deep network learning and training. Finally, a hybrid design method of deep learning
and optical design was realized and verified.

Results:
Compared with the traditional method, this method is more efficient. Here, we used a deep
neural network(DNN) to accelerate the freeform optical design. After the DNN was trained by a
sample set consisting of a uniform pattern and eight different Chinese characters represented by an
array with 11 × 11, it can generate a character's reflector within few milliseconds.

Conclusion:
As proof of this new method, a character pattern reflector was manufactured and tested,
and the experimental irradiance distribution was found close to the expectation, which means
that the neural network has the excellent capability to memorize all of the learned characters. SQM
combined with DNN has the potential to establish a particular “optical font library” and even offers
a promising path for rapid freeform optical design to realize the function of “optical typography”.
Identifying Frequent Health Care Users and Care Consumption Patterns: Process Mining of Emergency Medical Services Data
Authors: Maruster Laura , van der Zee Durk-Jouke , Buskens Erik 
Published: October 2021

Background
Tracing frequent users of health care services is highly relevant to policymakers and clinicians, enabling them to avoid wasting scarce resources. Data collection on frequent users from all possible health care providers may be cumbersome due to patient privacy, competition, incompatible information systems, and the efforts involved.

Objective
This study explored the use of a single key source, emergency medical services (EMS) records, to trace and reveal frequent users’ health care consumption patterns.

Methods
A retrospective study was performed analyzing EMS calls from the province of Drenthe in the Netherlands between 2012 and 2017. Process mining was applied to identify the structure of patient routings (ie, their consecutive visits to hospitals, nursing homes, and EMS). Routings are used to identify and quantify frequent users, recognizing frail elderly users as a focal group. The structure of these routes was analyzed at the patient and group levels, aiming to gain insight into regional coordination issues and workload distributions among health care providers.

Results
Frail elderly users aged 70 years or more represented over 50% of frequent users, making 4 or more calls per year. Over the period of observation, their annual number and the number of calls increased from 395 to 628 and 2607 to 3615, respectively. Structural analysis based on process mining revealed two categories of frail elderly users: low-complexity patients who need dialysis, radiation therapy, or hyperbaric medicine, involving a few health care providers, and high-complexity patients for whom routings appear chaotic.

Conclusions
This efficient approach exploits the role of EMS as the unique regional “ferryman,” while the combined use of EMS data and process mining allows for the effective and efficient tracing of frequent users’ utilization of health care services. The approach informs regional policymakers and clinicians by quantifying and detailing frequent user consumption patterns to support subsequent policy adaptations.
Enriching the Value of Patient Experience Feedback: Web-Based Dashboard Development Using Co-design and Heuristic Evaluation
Authors: Khanbhai Mustafa , Symons Joshua , Flott Kelsey , Harrison-White Stephanie , Spofforth Jamie , Klaber Robert , Manton David , Darzi Ara , Mayer Erik 
Published: October 2021

Background
There is an abundance of patient experience data held within health care organizations, but stakeholders and staff are often unable to use the output in a meaningful and timely way to improve care delivery. Dashboards, which use visualized data to summarize key patient experience feedback, have the potential to address these issues.

Objective
The aim of this study is to develop a patient experience dashboard with an emphasis on Friends and Family Test (FFT) reporting, as per the national policy drive.

Methods
A 2-stage approach was used—participatory co-design involving 20 co-designers to develop a dashboard prototype, followed by iterative dashboard testing. Language analysis was performed on free-text patient experience data from the FFT, and the themes and sentiments generated were used to populate the dashboard with associated FFT metrics. Heuristic evaluation and usability testing were conducted to refine the dashboard and assess user satisfaction using the system usability score.

Results
The qualitative analysis from the co-design process informed the development of the dashboard prototype with key dashboard requirements and a significant preference for bubble chart display. The heuristic evaluation revealed that most cumulative scores had no usability problems (18/20, 90%), had cosmetic problems only (7/20, 35%), or had minor usability problems (5/20, 25%). The mean System Usability Scale score was 89.7 (SD 7.9), suggesting an excellent rating.

Conclusions
The growing capacity to collect and process patient experience data suggests that data visualization will be increasingly important in turning feedback into improvements to care. Through heuristic usability, we demonstrated that very large FFT data can be presented in a thematically driven, simple visual display without the loss of the nuances and still allow for the exploration of the original free-text comments. This study establishes guidance for optimizing the design of patient experience dashboards that health care providers find meaningful, which in turn drives patient-centered care.
Exploring Children’s Engagement in Monitoring Indoor Air Quality: Longitudinal Study
Authors: Kim Sunyoung , Sohanchyk Gregory 
Published: October 2021

Background
Indoor air pollution is harmful to everyone, but children are of particular concern, as they are more vulnerable to its adverse health effects from air pollutants. Although mobile technology is increasingly being designed to support monitoring and improving air quality indoors, little attention has been paid to its use by and for children. Previously, we created inAirKids, a child-friendly device to promote children’s engagement with monitoring indoor air quality through a participatory design process. The next step is to evaluate its usability in the real world.

Objective
The aim of this study is to investigate how inAirKids affects children’s understanding of and engagement with indoor air quality through a longitudinal field deployment study.

Methods
We deployed inAirKids in the homes of 9 children aged between 6 and 7 years, and investigated their use for up to 16 weeks by conducting semistructured, biweekly interviews.

Results
The results show that participants promptly engaged with inAirKids but quickly lost interest in it owing to the lack of engaging factors to sustain engagement. In addition, we identified 2 design considerations that can foster sustained engagement of children with monitoring indoor air quality: design interactivity for engaging in continuity and corporate hands-on activities as part of indoor air quality monitoring for experiential learning.

Conclusions
Our findings shed light on the potential to promote the engagement of children in indoor air quality as well as considerations for designing a child-friendly digital device. To the best of our knowledge, this is the first longitudinal field deployment to investigate how to engage children in monitoring indoor air quality.
Timing of Kidney Clamping and Deceased Donor Kidney Transplant Outcomes
Authors: Ville Simon , Lorent Marine , Kerleau Clarisse , Asberg Anders , Legendre Christophe , Morelon Emmanuel , Buron Fanny , Garrigue Valérie , Le Quintrec Moglie , Girerd Sophie , Ladrière Marc , Albano Laetitia , Sicard Antoine , Glotz Denis , Lefaucheur Carmen , Branchereau Julien , Jacobi David , Giral Magali 
Published: October 2021

Background and objectives
The fact that metabolism and immune function are regulated by an endogenous molecular clock that generates circadian rhythms suggests that the magnitude of ischemia reperfusion, and subsequent inflammation on kidney transplantation, could be affected by the time of the day.

Design, setting, participants, & measurements
We evaluated 5026 individuals who received their first kidney transplant from deceased heart-beating donors. In a cause-specific multivariable analysis, we compared delayed graft function and graft survival according to the time of kidney clamping and declamping. Participants were divided into those clamped between midnight and noon (ante meridiem [am] clamping group; 65%) or clamped between noon and midnight (post meridiem [pm] clamping group; 35%), and, similarly, those who underwent am declamping (25%) or pm declamping (75%).

Results
Delayed graft function occurred among 550 participants (27%) with am clamping and 339 (34%) with pm clamping (adjusted odds ratio, 0.81; 95% confidence interval, 0.67 to 0.98; P=0.03). No significant association was observed between clamping time and overall death-censored graft survival (hazard ratio, 0.92; 95% confidence interval, 0.77 to 1.10; P=0.37). No significant association of declamping time with delayed graft function or graft survival was observed.

Conclusions
Clamping between midnight and noon was associated with a lower incidence of delayed graft function, whereas declamping time was not associated with kidney graft outcomes.
REPUBLIC OF THE OTHER
Authors: Xenia Mura Fink  , Jinny Yu  
Published: October 2021

REPUBLIC OF THE OTHER is an art collective consisting of and founded by Jinny Yu and Xenia Fink.
A contradiction in itself, REPUBLIC OF THE OTHER reflects our questioning of geographic and national identities defined by borders and boundaries and is the basis of our research on the attraction to form an entity.
Our collaboration started with the urgency to express our resistance against the generalized right-wing tendency, with nation-states and borders strengthening with great force worldwide and with the conviction that we have something to contribute to the discussion.
Manifestos as a subject matter are our way to describe a utopia where we all accept each other as an “other”.
Our practice is executed through exchanging and developing ideas from our respective locations. Remotely sharing thoughts naturally lend to working with text as a medium; when we occasionally do convene, concepts may also take the shape of installations and video work.
Monopoly Media: Efforts to Increase the Activity of Elementary School Students in Learning Animals Movement Organs
Authors: Prabali Luh Ayu Ratna Sawitri , Sukmana Adrianus I Wayan Ilia Yuda 
Published: October 2021

The low learning outcomes of fifth-grade students are caused by the lack of thematic learning media. Therefore, this study aimed at developing simple monopoly learning media on the subtheme of animal movement organs. The design of this study was development research based on ADDIE model. The collected data in this study were qualitative and quantitative data. The subjects in this study were a material expert, a media expert, an instructional design expert, and a learning practitioner. The data were collected through questionnaire. Then, the collected data were analyzed using descriptive qualitative and descriptive quantitate method. The results of this study show that the simple monopoly learning media developed is valid based on a review of material experts, reviews of learning media experts, and reviews of learning design experts with very good qualifications. Meanwhile, this learning media has good qualification to be used in thematic learning on the subtheme of animal movement organs. It is based on the result of teacher’s response to the developed media. It can be concluded that the monopoly learning media is suitable to in the thematic learning specially for learning animal movement organs. The implication of the result of this study is that it can help students be actively involved in meaningful and fun learning.
Science Learning with VideoScribe-Based Learning Video for Elementary School Students
Authors: Perdana Putra I Wayan Deni , Gading I Ketut , Dibia I Ketut 
Published: October 2021

There are still many teachers who do not manage to create a fun learning environment for students. Moreover, the lack of learning media makes it difficult for students to understand the learning material. This study aims to develop a learning video using the VideoScribe app to facilitate students ' learning. Development research was employed in this study, while 4-D was used as the research model. One selected subject content expert, one selected learning design expert, one preferred learning media expert, and two chosen people for the individual trial became the subject of this study. Observation, interviews, and questionnaires had been utilized to collect the data. A questionnaire was the instrument used to gather the data. The validity of the study instrument was evaluated with the Gregory formula. The data were analyzed using qualitative descriptive statistics and quantitative descriptive statistics methods. The results showed that this study got a score of 1.00 with a very high product acceptability coefficient. It could be concluded that the developed media was feasible to be applied in learning. This study implied that the learning video made students more easily understand science subject matter.
A portable calorimeter for measuring the calorific value of natural gas
Authors: Prysyazhnyuk Lyudmila , Petryshyn Ihor , Dolishnii Bohdan , Ropyak Liubomyr 
Published: October 2021

Abstract
Natural gas quality assessment is a relevant issue. A critical analysis of calorimeter designs for measuring the calorific value of natural gas was carried out. The most common methods for determining the calorific value of natural gas are as follows: direct by gas calorimeters; indirect by gas chromatographs; indirect, based on correlations. The advantages of isoperibolic calorimeters of measuring calorific value of natural gas directly in the consumer’s conditions are substantiated. The design of a portable calorimeter containing a thermostated shell, calorimetric tank, Peltier element with tank, circulating pump, gas burner, thermostat systems, metered supply of natural gas and air, fuel ignition, sensors, combustion analyzer and control and measurement unit, was developed. The geometric dimensions of the calorimetric tank are optimized, materials and technologies of manufacturing parts are specified. The metrological analysis of the developed portable calorimeter was carried out. A method for measuring the calorific value of natural gas directly in the conditions of household consumers and transport enterprises was developed. The results of testing the prototype calorimeter in the laboratory confirmed its high performance and metrological characteristics, and the deviation of the measurement of the calorific value of natural gas from that determined using a gas chromatograph was 0.6%.
String of Relationship in the Sky of Multiculturalism: A Reading of Khaled Hosseini’s The Kite Runner
Authors: Narimadakkal Nasri , Arul Mr. J 
Published: October 2021

This paper proposes how the relationship that exists between different characters in his novels is experimented in diverse conditions and the characters are tested and tried to discover their unique paths of assimilation with their loved ones to the completion of their circle. Despite the spatial differences, each character is connected with a string of bond which portrays the ‘similarity’ of difference, yet humanity in need of understanding. The physical space and emotional space of Baba’s beautiful house in the Wazir Akbar Khan district is contrasted with the shack of Hassan and Ali breaks the dichotomy of contentment and dissatisfaction. Simultaneously with the diversity of multiculturalism it creates fantasies of escape from ideological and cultural divisions altogether. Interconnected relationship and affections blur the ethnic, social, geographical and economic variances in individual.The characters all experience a personal journey for love in their own way through their words and actions. The genetic ties to the geographies of privilege, ethnic difference and social status often challenged through the personal affinity. Troubled relationship like Baba and Amir, or an enigmatic friendship like Amir and Hassan or passive bond like Ali and Hassan or even a romantic relationship like Amir and Soraya are circulating the web of ontology. Relationship, assimilation and struggle of people cross path with desperate societies resulting a relief from haunting memories. The longing for love and to be loved draw the characters to find the web of their completeness and ultimately that give them the strength to fight back with their vulnerabilities , surpass their limitations, and eventually to purify their guilt through overwhelming acts of self-sacrifice.
DEVELOPING SPEAKING SKILL OF GRADE VIII STUDENTS AT SMP NEGERI 1 PALU THROUGH INTERVIEW
Authors: Syam Hijrah , Pettawali M. Tamrin AM. S. 
Published: October 2021

This research aims at developing Speaking Skill through Interview. Its method was quasi-experimental research non-equivalent control group design. Its population was the students of grade VIII at SMP Negeri 1 Palu, in which consists of thirteen parallel classes. The experimental class consists of 29 students and control class consists of 30 students. It was done in eight meetings. The variables of this research were speaking skill and interview. The samples of this research were students of grade VIII C and VIII D, selected through cluster sampling technique. Its results indicate that the application of interview has overcome the students’ problem. After analyzing them, the result of t-counted was 10.01. By applying degree of freedom (df) 57(29+30-2), and the level significant 0.05, the value of t-table was 2.00. So, the value of t-counted was higher than t-table. It means that the hypothesis of this research was accepted. Thus, the interview can be applied to develop speaking skill of students grade VIII at SMP Negeri 1 Palu.