bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Historical and Future Water Availability in Himalayan Tamor River Basin Nepal Utilizing CMIP5 CNRM Climate Model Experiments
Authors: Pokhral Bishal , Singh Vishal , Mishra S. K. , Jain Sanjay K , Singh Pushpendra K , Bansal Joshal K 
Published: November 2021

Abstract
In this study, the assessment of water availability under climate changing environment has been done in the Himalayan Tamor River Basin, Nepal using physically based, spatially distributed, a continuous model 'Soil and Water Assessment Tool' (SWAT). The hydrological simulation and projection have been performed in the historical (1996-2007) and future times (e.g. 30s, 40s, 50s, 60s, 70s, 80s, 90s). The climate change impact assessment on the hydrology of Tamor river basin has been performed utilizing the CMIP5 CNRM climate model datasets (with RCP4.5 and RCP8.5). The model calibration and parameterization uncertainty evaluation in the simulated and projected flows were done in SWATCUP using SUFI2 algorithm. The results obtained from the model calibration (1996-2004) and validation (2005-2007) showed a reliable estimate of daily streamflow for calibration period (R2 = 0.85, NSE =0.85 and PBIAS=-2.5) and validation period (R2 =0.87, NSE =0.85 and PBIAS=-5.4). The average annual water yield at the main outlet of the basin is computed as 1511.13 mm, and the total annual quantity is recorded as 6.25 BCM. The average annual precipitation over the seleced river basin is projected to be increased in all scenarios. The stations at higher altitude show more temperature rise than those at a lower elevation and thus there would be minimal snowfall has been projected in the basin by 2100 AD under both scenarios (RCP4.5 and RCP8.5). It is expected that the flow pattern in the future would be similar to the baseline pattern under all scenarios. The baseflow will be dramatically increased in all scenarios, but the lowest flow month would be shifted from March to February. Since the base flow during lean months would be increased in future as projected by all scenarios, there would not be adverse impacts on higher percentile flows. This study would be useful for the assessment of the possibility of storage type or run-off-river type hydro-project in the basin in terms of water availability.
Olfactory Responses of Trissolcus Mitsukurii to Plants Attacked by Target and Non-target Stink Bugs Suggest Low Risk for Biological Control
Authors: Rondoni Gabriele , Chierici Elena , Giovannini Lucrezia , Sabbatini-Peverieri Giuseppino , Roversi Pio Federico , Conti Eric 
Published: November 2021

Abstract
In crop systems, successful management of invasive insect herbivores can be achieved through the introduction of exotic biocontrol agents, i.e. parasitoids or predators, having a coevolutionary history with the pest. To avert threats to local biodiversity, recent legislations require a risk assessment for the organism to be released. Evaluation of its ability to exploit, for host location, odours associated with target and non-target species is crucial for a better definition of its ecological host range. Using Y-tube olfactometer in quarantine laboratory, we investigated the ability of the Asiatic egg parasitoid Trissolcus mitsukurii (Hymenoptera: Scelionidae) to exploit odours associated with the global invader Halyomorpha halys (Hemiptera: Pentatomidae) and with non-target stink bugs native to Southern Europe. We demonstrated that T. mitsukurii is attracted by plants exposed to feeding and egg deposition of the coevolved H. halys or the native Nezara viridula, while it is not attracted by physogastric females or eggs alone. Remarkably, T. mitsukurii is repelled by plants bearing eggs of the beneficial stink bug, Arma custos. Our results usefully contribute to a more thorough and nuanced assessment of the potential non-target risks in case of massive parasitoid release.
I’ll be Good for Grandma: Institutional and Relational Trust and COVID-19 Restriction Compliance
Authors: Andrade-Molina Derly M , Fernandez-Cadena Juan Carlos , Fernandez Mario A , Rhodes Lauren A , Sanchez Gonzalo E 
Published: November 2021

Abstract
behavior with health campaigns. We examine Guayaquil, Ecuador which was hit particularly hard in the first few months of the pandemic. As lockdowns and social distancing led families to rely on others to secure food or medical assistance, perceptions on trust and the dynamics of social capital during the initial (and worst) months of the pandemic were particularly important. Methods: This paper uses a unique dataset of people receiving a COVID test after suspicion of infection. People in our dataset were active during the height of the pandemic and faced the possibility of needing to rely on others in the case of testing positive. We use regression analysis to study the relation between compliance with mobility restrictions and institutional and relational trust.Results: We find that trusting that close relations (such as family) will be there for you in the case of falling ill is associated with a significant increase in the probability of complying with health campaigns. Additionally, we find that trust in the government has a weak relationship to compliance. However, compliance decreases when examining increased trust in the police but increases with trust in the military.Conclusions: The findings show that enhancing trust may improve compliance with social distancing measures. However, increasing trust in specific groups could have negative consequences. Importantly, compliance could be increased by emphasizing in campaigns that your behavior could influence the health of those who you care about.
How Intracranial Thrombi Embed Along The Stent Retriever Following Mechanical Thrombectomy. A High-Resolution Scanning Electron Microscopy Analysis.
Authors: Grange Daniela Dumitriu La , Bernava Gianmarco , Reymond Philippe , Wanke Isabel , Vargas Maria Isabel , Machi Paolo , Lövblad Karl-Olof 
Published: November 2021

Abstract
Endovascular treatment with stent retriever thrombectomy is a major advancement in the standard of care in acute ischemic stroke (AIS). The modalities through which thrombi embed along stent retriever following mechanical thrombectomy (MTB) remain to be elucidated. Using scanning electron microscopy (SEM), we analyzed the behavior of thrombi embedded onto the stent, when retrieved by MTB from patients, victims of AIS. We observed that incorporation of thrombi is achieved through loosely packed, non-compact regions. We hypothesize that structural heterogeneity modulation of thrombi, in terms of compact and non-compact regions, is related to the endovascular treatment outcome.
Remote expert elicitation to determine the prior probability distribution for Bayesian sample size determination in international randomized controlled trials: Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone (BIPED) Study
Authors: Lan Jingxian , Plint Amy C , Dalziel Stuart R , Klassen Terry P , Offringa Martin , Heath Anna 
Published: November 2021

Abstract
BackgroundBayesian methods are increasing in popularity in clinical research. The design of Bayesian clinical trials requires a prior distribution, which can be elicited from experts. Current elicitation approaches either use face-to-face sessions or expert surveys. In diseases with international differences in management, the elicitation exercise should recruit internationally, requiring expensive face-to-face sessions or surveys, which suffer low response rates. To address this, we developed a remote, real-time elicitation exercise to construct prior distributions. These elicited distributions were then used to determine the sample size of the Bronchiolitis in Infants with Placebo Versus Epinephrine and Dexamethasone (BIPED) Study, an international randomized controlled trial trial in the Pediatric Emergency Research Network (PERN). The BIPED study aims to determine whether the combination of epinephrine and dexamethasone, compared to placebo, is effective in reducing hospital admission for infants presenting with bronchiolitis to the emergency department.MethodsWe developed a web-based tool to support the elicitation of the probability of hospitalization for infants with bronchiolitis. Experts participated in online workshops to specify their individual prior distributions, which were aggregated using the equal-weighted linear pooling method. The Average Length Criterion determined the BIPED sample size.ResultsFifteen paediatric emergency medicine clinicians from Canada, USA, Australia and New Zealand participated in three workshops to provide their elicitied prior distributions. The elicited probability of admission for infants with bronchiolitis was slightly lower for those receiving epinephrine and dexamethasone compared to supportive care in the aggregate distribution. There were substantial differences in the individual beliefs but limited differences between North America and Australaisia. From this aggregate distribution, a sample size of 410 patients per arm results in an average 95% credible interval length of less than 9% and a relative predictive power of 90%.ConclusionRemote expert elicitation is a feasible, useful and practical tool to determine a prior distribution for international randomized controlled trials. Bayesian methods can then determine the trial sample size using these elicited prior distributions. The ease and low cost of remote expert elicitation means that this approach is suitable for future international randomized controlled trials.Trial Registration: clinicaltrials.gov Identifier: NCT03567473
Human Health Risks Surveillance of Polychlorinated Biphenyls in Bovine Milk from Alluvial Plain of Punjab, Pakistan
Authors: Sana Saman , Qadir Abdul , Evans Neil P , Mumtaz Mehvish , Javaid Ambreena , Khan Amjad , Kashif Saif-ur-Rehman , Rehman Habib ur 
Published: November 2021

Abstract
Punjab is the leading province of Pakistan in the production of bovine milk and its consumption. Rapid industrialization, high energy demand and production of waste have increased the risk of PCB toxicity in the environment. This research work was designed to assess human dietary exposure of polychlorinated biphenyls (∑PCBs 17 congeners) through ingestion of buffalo and cow’s milk from eight main districts of Punjab, Pakistan. The average concentration of ∑DL-PCBs in buffalo and cow milk samples were analyzed (8.74 ng g-1 and 14.60 ng g-1) and ∑I-PCBs (11.54 ng g-1 and 18.68 ng g-1) respectively. The PCB-156 was predominantly high congener found in both buffalo (2.84 ng g-1) and cow milk (2.86 ng g-1). It was found that the highest PCBs in bovine milk samples were observed in close vicinities of urban and industrial areas. The estimated daily consumptions of DL-PCBs and I-PCBs, from buffalo and cow milk, were below the acceptable daily intake for both adults and children. Moreover, Hazard Quotients (HQ) of ∑PCBs17 congeners value were less than 1.0 in adults and greater in the case of children reflecting the high chances of cancer risk. Furthermore, comprehensive monitoring for childhood cancer is recommended to establish the relationship in future studies.
Battling the Emerging Epidemic of Rhino-Orbital-Cerebral Mucormycosis (ROCM) in COVID-19 Pandemic: A Prospective Interventional Study
Authors: Gandhi Aastha , Narula Anurag , Chandra Shreya , Agarwal Dhwanee , Mehta Anuj , Arora Sheetal , Nayak Shaktiprada , Capoor Malini R 
Published: November 2021

Abstract
Purpose: The most recent challenge being faced by the healthcare system during the worldwide COVID-19 pandemic is increase in the incidence rate of coinfection or superinfection; one of the most fatal being mucormycosis. This study aimed to estimate the risk factors, symptoms and signs, treatment outcome and prognosis of COVID-19-associated mucormycosis (CAM) patients. Methods: This is a prospective, interventional study of 35 patients diagnosed and managed as CAM at a tertiary care centre in New Delhi, India. Results: The mean age of patients was 40.45± 6 years with a male preponderance. CAM did not affect healthy individuals; the major risk factors included diabetes in 65.7% and injudicious steroid use in 51.4% patients. Orbital/facial edema was the most common presenting symptom (25.7%) as well as sign (28.57%). 68.5% patients were stage 3 (involvement of orbit) at presentation; 33.3% showed medial wall involvement. Treatment included intravenous amphotericin and oral posaconazole in all patients, paranasal sinus (PNS) debridement in 94.2%, orbital exenteration was done in 8 patients. Adjuvant retrobulbar amphotericin B injection was administered in 12 patients with radiological resolution seen in 50% after 1 cycle. In patients with Stage 4 disease who underwent exenteration along with PNS debridement, survival rate was 100% at 30 days, and disease reduction occurred in 87.5% patients (P<0.01). Overall, 68.5 % responded to therapy, 8.5 % showed progression and mortality rate was 22.85 %, at a mean follow up period of 59.5 days.Conclusion: A multidisciplinary and aggressive approach is essential in the management of CAM patients.
Hydrothermal carbonization of sewage sludge: Multi-response optimization of hydrochar production and CO2-assisted gasification performance
Authors: Guo Shuai , Xu DanDan , Guo Xin , Li Xingcan , Zhao Chenchen 
Published: November 2021

Abstract
The harmful effects of improper sewage sludge (SS) treatment on the environment inspire the search for more benign sludge processing techniques such as hydrothermal carbonization (HTC); the abundant organic matter in SS is used for energy recovery. Herein, response surface methodology (RSM) was used to optimize the HTC-based preparation of SS hydrochar and its gasification performance. Specifically, the hydrochar yield, higher heating value (HHV), and gasification activity index were selected as optimization goals, while carbonization temperature (160–260°C), residence time (30–150 min), and acetic acid concentration (0–1.5 M) were selected as factors influencing the HTC process and CO2-assisted gasification performance. Carbonization temperature was the dominant parameter determining hydrochar yield, HHV, and gasification activity. The hydrochar yield (82.69%) and calorific value (7820.99 kJ kg−1) were maximized under comparatively mild conditions (160°C, 30 min, and 0.07 M acetic acid), whereas the gasification activity index (0.288 s−1) was maximized under harsher conditions (211.34°C, 88.16 min, and 1.58 M acetic acid). The obtained results help to guide the HTC of SS intended for gasification, thus promoting the development of this promising waste-to-energy technology, and may facilitate the design and further optimization of thermochemical SS conversion.
A systematic review of the accessibility, acceptability, safety, efficiency, clinical effectiveness and cost-effectiveness of private providers of elective surgical services compared with public providers
Authors: Akpinar Ilke , Kirwin Erin , Tjosvold Lisa , Chojecki Dagmara , Round Jeff 
Published: November 2021

Abstract
Many publicly funded health systems use a mix of privately and publicly operated providers of care to deliver elective surgical services. We review the role of private elective surgical provision within publicly funded health systems in high-income countries. The outcomes evaluated include accessibility, acceptability, safety, clinical effectiveness, efficiency, and cost/cost-effectiveness. Twenty-seven articles met the review inclusion criteria. We found mixed results across each of our reported outcomes. Wait times were shorter for patients treated in private facilities in most studies, and inequalities by age and socioeconomic deprivation were found to increase with private provision in some studies. Acceptability results were mixed, with most studies finding no differences between public and private provision and others finding higher satisfaction at public facilities. The results for safety outcomes were divided, but most studies that found improved safety outcomes in private facilities, noting that private patients had a lower preoperative risk of complications. Clinical effectiveness was similar in most studies, with differences in outcomes mainly attributed to patient selection or prosthesis choice. Very few studies reported cost and cost-effectiveness outcomes, and just two included studies concluded that private facilities are economically viable.
Shuangxinfang prevents S100A9-induced macrophage/microglial inflammation to improve cardiac function and depression-like behaviour in rats after acute myocardial infarction
Authors: Sun Yize , Wang Zheyi , Hou Jiqiu , Shi Jinyu , Tang Zhuoran , Wang Chao , Zhao Haibin 
Published: November 2021

Abstract
Background

Depression is a common complication of cardiovascular disease, which deteriorated the cardiac function. Shuangxinfang (Psycho-cardiology Formula, PCF) was reported to alleviate myocardial ischemia injury and improve depression-like behavior. Interestingly, our previous proteomics study predicted that the protein S100A9 appeared as an important target, and macrophage/microglial inflammation might be involved in the process of PCF treating depressive disorder induced by acute myocardial infarction (AMI). The aim of this study is to validate the proteomics results.
Methods

AMI rat models were established in vivo, followed by the administration of PCF or ABR-215757 (also named paquinimod, inhibiting S100A9 binding to TLR4) for 5 days. Forced swimming test (FST) and open field test (OFT) were applied to record depression-like behavior, and echocardiography was employed to evaluate cardiac function. Morphological changes of cardiomyocytes were assessed by HE staining and TUNEL staining on day 7 after cardiac surgery, as well as masson trichrome staining on day 21. Hippocampal neurogenesis was determined by Nissl staining, while 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) in the hippocampus were detected as biochemical indicators of depression. Myocardial and hippocampal expression of inflammatory factors were analyzed by western blotting, immunofluorescence, and ELISA. The activation state of macrophage and microglia was assessed via immunoreaction respectively using CD68 and Iba1. For in vitro confirmation, BV2 cells were primed with recombinant protein S100A9, and then pretreated with PCF serum, to determine alterations in microglial activation and inflammation.
Results

Rats in the AMI group showed heart function deterioration, as well as depression-like behavior. Coronary ligation not only brought about myocardial inflammation, cell apoptosis and fibrosis, but also reduced the neurogenesis and decreased the content of 5-HT. PCF could ameliorate the pathological and phenotypic changes of the heart and brain, and inhibited the expression of S100A9/TLR4/NF-κB pathway, the activation of microglial cell and the secretion of IL-1β and TNF-α raised by AMI. ABR-215757 showed therapeutic effect and molecular biological mechanisms similar to PCF. Pretreatment with PCF serum in vitro was proved to efficiently block the hyperactivation of BV2 cells and increasement of cytokine contents induced by recombinant protein S100A9.
Conclusion

We identify S100A9 as a novel and potent regulator of inflammation in both heart and brain. Macrophage/microglia inflammation mediated by S100A9 is considered as a pivotal pathogenic in depression post-AMI, as well as a major pathway for the treatment of PCF, suggesting that PCF is a promising therapeutic candidate for psycho-cardiology disease.
Potential Novel Therapeutic Targets In Epilepsy From The View of Intestinal Comorbidities - Inflammatory Bowel Disease
Authors: Jiang Mi , Li Jia , Song Zhi 
Published: November 2021

Abstract
Background: Epilepsy is a complicated neurological disorder with almost 30% refractory. Recent years, several studies showed that epilepsy is associated with its comorbidities by shared molecular mechanisms. However, the association of epilepsy and digestive comorbidities are still unclear. In this study, we aim to explore the association between inflammatory bowel disease (IBD) and epilepsy, and to find promising therapeutic targets for refractory epilepsy. Methods: Two gene expression profiles (GSE134697 and GSE59071) were selected from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by GEO2R and the DESeq2 package. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of intersection DEGs and Gene Set Enrichment Analysis (GSEA) were conducted by clusterProfiler package. The protein-protein interactions (PPI) network was established by using STRING and visualized by Cytoscape. Genes in the most significant module identified by MCODE plug-in were considered as candidate hub genes. Validation of hub genes were performed by using the GSE143272 dataset. Results: Cytokine-cytokine receptor interaction pathway is identified as a communal pathway between IBD and epilepsy. CXCL8, CXCR4 and ITGAX were identified as the hub genes. Conclusions: The identification of the communal pathway and hub genes in this study contributes to a potential novel therapeutic target in refractory epilepsy.
Prognostic Accuracy of a Novel Prognostic Score Using a Combination of PCT, DDi, and Lactate Biomarkers in Patients With Sepsis: A Retrospective Cohort Study
Authors: miao Yansong , Xing LiFeng 
Published: November 2021

Abstract
Background
A combination of multiple biomarkers will be more accurate in predicting the mortality of sepsis patients. Herein, we aimed to assess the ability to predict adverse outcomes of a novel scoring system using the combination of PCT, DDi, and lactate (PDLS) in patients with sepsis from the emergency department (ED) of a hospital.
Methods
The patients’ baseline characteristics, main laboratory data and outcome were collected from the patient's electronic medical record. A receiver operating characteristic curve (ROC) analysis determine the optimal cutoff points for biomarkers PCT, DDi and lactate and establish a PDLS system based on their cutoff points. ROC was used to compare the accuracy of PDLS to Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores in predicting short-term mortality in patients with sepsis.
Results
The analysis cohort included 1001 patients. 117 sepsis patients died in 28 days. An increase in PDLS was associated with higher mortality and adverse events including MV, VD, AICU, and CRRT. PDLS was an independent predictor of 28-day mortality, MV, VD, AICU, and CRRT. The Area Under the Receiver Operating Characteristic curve (AUROC) of PDLS (0.96; Cl=0.94-0.98) was significantly higher than that of SOFA (0.84; Cl=0.80-0.89) and APACHE II (0.84; Cl=0.79-0.88).
Conclusion
PDLS is an independent prognostic predictor of adverse clinical outcomes for sepsis patients and was superior to other prognostic scores, including SOFA and APACHE II.