bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polypore fungi as a flagship group to indicate changes in biodiversity – a test case from Estonia
Authors: Runnel Kadri , Miettinen Otto , Lõhmus Asko 
Published: January 2021

AbstractPolyporous fungi, a morphologically delineated group of Agaricomycetes (Basidiomycota), are considered well studied in Europe and used as model group in ecological studies and for conservation. Such broad interest, including widespread sampling and DNA based taxonomic revisions, is rapidly transforming our basic understanding of polypore diversity and natural history. We integrated over 40,000 historical and modern records of polypores in Estonia (hemiboreal Europe), revealing 227 species, and including Polyporus submelanopus and P. ulleungus as novelties for Europe. Taxonomic and conservation problems were distinguished for 13 unresolved subgroups. The estimated species pool exceeds 260 species in Estonia, including at least 20 likely undescribed species (here documented as distinct DNA lineages related to accepted species in, e.g., Ceriporia, Coltricia, Physisporinus, Sidera and Sistotrema). Four broad ecological patterns are described: (1) polypore assemblage organization in natural forests follows major soil and tree-composition gradients; (2) landscape-scale polypore diversity homogenizes due to draining of peatland forests and reduction of nemoral broad-leaved trees (wooded meadows and parks buffer the latter); (3) species having parasitic or brown-rot life-strategies are more substrate-specific; and (4) assemblage differences among woody substrates reveal habitat management priorities. Our update reveals extensive overlap of polypore biota throughout North Europe. We estimate that in Estonia, the biota experienced ca. 3–5% species turnover during the twentieth century, but exotic species remain rare and have not attained key functions in natural ecosystems. We encourage new regional syntheses on long studied fungal groups to obtain landscape-scale understanding of species pools, and for elaborating fungal indicators for biodiversity assessments.
Non-invasive IGFBP1, IGFBP2 biomarkers as predictors and outcomes of usual interstitial pneumonia (UIP) therapeutic response
Authors: Habeb M. , Embarak S. , Fathy A. , Zalat M. 
Published: January 2021

Abstract
Background
Usual interstitial pneumonia (UIP) is a fatal disease that is associated with poor prognosis and survival. Several growth factors such as IGFs (insulin-like growth factors) and IGFBPs (insulin-like growth factor binding proteins) seem to take part to this pathogenesis.
Pirfenidone is an immunosuppressant drug that is thought to have anti-inflammatory and anti-fibrotic effects both in vitro and in vivo.

Objective
To assess IGFBP1 and IGFBP2 as non-invasive biomarkers for prediction and outcomes of UIP clinical activity and therapeutic response to the anti-fibrotic pirfenidone.

Results
Serum levels of IGFBP1 and IGFBP2 were significantly higher in the UIP group than in the healthy subjects (p ≤ 0.005). After 6 months therapy, UIP patients were divided into 2 groups according to improvement in MRC dyspnea grading into clinically improved and non-improved groups. 6MWT and SPaO2 were significantly improved in the clinically improved group compared to the non-improved one with no differences as regards other parameters (p < 0.0001). Both IGFBP1 and IGFBP2 were significantly decreased in serum while only IGFBP2 was decreased in BAL of all UIP after completing 12 months therapy.

Conclusion
IGFBP1 and IGFBP2 were increased in active UIP patients and reduced after 12 months anti-fibrosing therapy. IGFBPs may be promising biomarkers and predictors of response to therapy in UIP.
CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains
Authors: Kimura Toshiya , Saito Hiroko , Kawasaki Miwa , Takeichi Masatoshi 
Published: January 2021

ABSTRACT
Microtubules (MTs) regulate numerous cellular processes, but their roles in brain morphogenesis are not well known. Here, we show that CAMSAP3, a non-centrosomal microtubule regulator, is important for shaping the lateral ventricles. In differentiating ependymal cells, CAMSAP3 became concentrated at the apical domains, serving to generate MT networks at these sites. Camsap3-mutated mice showed abnormally narrow lateral ventricles, in which excessive stenosis or fusion was induced, leading to a decrease of neural stem cells at the ventricular and subventricular zones. This defect was ascribed at least in part to a failure of neocortical ependymal cells to broaden their apical domain, a process necessary for expanding the ventricular cavities. mTORC1 was required for ependymal cell growth but its activity was downregulated in mutant cells. Lysosomes, which mediate mTORC1 activation, tended to be reduced at the apical regions of the mutant cells, along with disorganized apical MT networks at the corresponding sites. These findings suggest that CAMSAP3 supports mTORC1 signaling required for ependymal cell growth via MT network regulation, and, in turn, shaping of the lateral ventricles.
Sustainable data analysis with Snakemake
Authors: Mölder Felix , Jablonski Kim Philipp , Letcher Brice , Hall Michael B. , Tomkins-Tinch Christopher H. , Sochat Vanessa , Forster Jan , Lee Soohyun , Twardziok Sven O. , Kanitz Alexander , Wilm Andreas , Holtgrewe Manuel , Rahmann Sven , Nahnsen Sven , Köster Johannes 
Published: January 2021

Data analysis often entails a multitude of heterogeneous steps, from the application of various command line tools to the usage of scripting languages like R or Python for the generation of plots and tables. It is widely recognized that data analyses should ideally be conducted in a reproducible way. Reproducibility enables technical validation and regeneration of results on the original or even new data. However, reproducibility alone is by no means sufficient to deliver an analysis that is of lasting impact (i.e., sustainable) for the field, or even just one research group. We postulate that it is equally important to ensure adaptability and transparency. The former describes the ability to modify the analysis to answer extended or slightly different research questions. The latter describes the ability to understand the analysis in order to judge whether it is not only technically, but methodologically valid.Here, we analyze the properties needed for a data analysis to become reproducible, adaptable, and transparent. We show how the popular workflow management system Snakemake can be used to guarantee this, and how it enables an ergonomic, combined, unified representation of all steps involved in data analysis, ranging from raw data processing, to quality control and fine-grained, interactive exploration and plotting of final results.
Exploring factors that influence the practice of Open Science by early career health researchers: a mixed methods study
Authors: Zečević Ksenija , Houghton Catherine , Noone Chris , Lee Hopin , Matvienko-Sikar Karen , Toomey Elaine 
Published: January 2021

Background: There is a growing global movement towards open science and ensuring that health research is more transparent. It is vital that the researchers are adequately prepared for this research environment from early in their careers. However, limited research has been conducted on the barriers and enablers to practicing open science for early career researchers. This study aimed to explore the views, experiences and factors influencing open science practices amongst ECRs working in health research. Methods: Semi-structured individual interviews were conducted with a convenience sample of ECRs working in health research. Participants also completed surveys regarding the factors influencing open science practices. Thematic analysis was used to analyse the qualitative data and descriptive statistical analyses were used to analyse survey data. Results: 14 ECRs participated. Two main themes were identified from interview data; Valuing Open Science and Creating a Culture for Open Science. Within ‘Valuing Open Science’, participants spoke about the conceptualisation of open science to be open across the entire research cycle, and important for producing better and more impactful research for patients and the public. Within ‘Creating a Culture of Open Science’ participants spoke about a number of factors influencing their practice of open science. These included cultural and academic pressures, the positives and negatives of increased accountability and transparency, and the need for more training and supporting resources to facilitate open science practices. Conclusion: ECRs see the importance of open science for beneficially impacting patient and public health but many feel that they are not fully supported to practice open science. Resources and supports including education and training are needed, as are better incentives for open science activities. Crucially, tangible engagement from institutions, funders and researchers is needed to facilitate the development of an open science culture.
Assessing and protecting the mental health of the nation: A study protocol
Authors: Hyland Philip , Vallières Frédérique 
Published: January 2021

Background: Coronavirus disease 2019 (COVID-19) and the public health measures enacted to control its spread may affect the mental health of the general population of Ireland. Funded under the Health Research Board’s COVID-19 Pandemic Rapid Response Funding Call, this protocol outlines the aims of a project to assess and protect the mental health of the population of Ireland during this pandemic. We will determine (i) the prevalence of common mental health disorders at various times during the first year of the pandemic, (ii) changes in the prevalence of mental health disorders during the first year of the pandemic, (iii) if there are distinct groups of people experiencing different mental health responses to the pandemic, and (iv) the factors associated with different mental health reactions. Methods: This quantitative study uses cross-sectional and longitudinal designs. Data have been collected from a nationally representative sample of Irish adults at four assessments: Wave 1 (N = 1,041) occurred during the first week of lockdown in March 2020, Wave 2 in May, Wave 3 in August, and Wave 4 in December. Wave 5 is planned for March 2021. Participants from Wave 1 have been recontacted at each wave to produce a longitudinal dataset. New participants were recruited using quota sampling to ensure the availability of nationally representative samples at each wave. Self-report measures of demographic, economic, psychological, and mental health variables were completed. Conclusion: This design will allow us to determine whether there has been a change in mental health disorders in the general population during the first year of the pandemic, and if so, what variables are associated with changes in mental health. Results will be used to inform the government’s ongoing response to this crisis, to better protect the mental health of the nation during this and any future public health emergency.
SOME ASPECTS OF THE EMOTIONAL AND PSYCHOLOGICAL STATUS OF STATE AND MUNICIPAL EMPLOYEES
Authors: Sabyna E. N. 
Published: January 2021

Research shows that not only material motivation is important for employees, but also intangible motivation. Great importance in the labor economy is attached to socio-psychological factors that affect labor productivity and increase labor potential. Psychological factors of working conditions directly affect the employee’s desire to perform their duties as effectively as possible.
The article deals with some psychological factors of working conditions and prevention of stress factors. The author presents the results of a study of the features of the emotional and psychological state («emotional burnout») identified in state and municipal servants. The number of stress factors in these groups of employees is large. Based on the conducted interview, the causes that provoke emotional burnout were identified. More than half of respodents have signs of burnout and exhaustion. The most clearly formed symptoms are «inadequate emotional selective response» and «reduction of professional responsibilities». The article offers recommendations aimed at preventing and correcting symptoms of emotional burnout. Recommendations can be used in HR technologies when working with personnel.
The article presents the results of the conducted research into the peculiarities of emotional burnout of state and municipal officials, and develops recommendations aimed at preventing and correcting the symptoms of emotional burnout. Recommendations can be used in HR technologies when working with employees of the organization.
Catalogação descritiva e temática de documentos musicais no contexto da biblioteca universitária
Authors: Figueiredo Diego Rodrigues , Souza Joice Cleide Cardoso Ennes de , Souza Elisabete Gonçalves de 
Published: January 2021

Objetiva analisar a catalogação descritiva e temática do documento musical, mais especificamente partitura, no âmbito da biblioteca universitária, de forma a discutir os aspectos relevantes a serem considerado no tratamento informacional desse recursos. Pesquisa de natureza básica, com abordagem qualitativa, bibliográfica e descritiva. A partir da análise da partitura musical de piano “Dansa Brasileira” de Camargo Guarnieri, depositada na Biblioteca Setorial do Centro de Letras e Artes da UNIRIO, destacou-se os aspectos adotados no tratamento informacional do documento à luz da literatura da área. Conclui-se que, para o tratamento informacional de um documento musical, é necessário que o catalogador desenvolva competência informacional de forma a conhecer as particularidades do documento e explorar o seu potencial informacional.
Piezoelectric energy generation in India: an empirical investigation
Authors: Anand Hari , Singh Binod Kumar 
Published: January 2021

Abstract
The consumption of energy has always been in exponential growth and also there is always an increasing demand in the requirement of energy in some way or the other. So, there is a need to search for energy availability from alternate sources of energy. The utilization of waste energy of foot power with human locomotion is relevant and important for highly populated countries like India where the railway station, temples, etc., are overcrowded all round the clock. When the flooring is engineered with piezoelectric technology, the electrical energy produced by the pressure is captured by floor sensors and converted to an electrical charge by piezo transducers, then stored and used as a power source. This paper deals with the generation of alternate sources of energy through piezoelectric materials. This research describes the use of piezoelectric materials to harvest energy from people walking vibration for generating and accumulating energy. This study also studies the perceptions and adaptability of piezoelectricity. The adaptability of piezoelectric technology in a real-time environment has been studied by comparing the overall cost of generating electricity with solar energy. This study also suggests a footstep of the piezoelectric energy harvesting model which is cost-effective and easy to implement.
Two Novel Variants in Genes of Arrhythmogenic Right Ventricular Cardiomyopathy – a Case Report
Authors: Gabartaitė Dovilė , Jančauskaitė Dovilė , Mikštienė Violeta , Preikšaitienė Eglė , Norvilas Rimvydas , Valevičienė Nomeda , Marinskis Germanas , Aidietis Audrius , Barysienė Jūratė 
Published: January 2021

Background. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiomyopathy, characterized by fibrofatty replacement of myocytes in the right ventricular, left ventricular or both ventricles. It is caused by pathogenic variants of genes encoding desmosomal (JUP, DSP, PKP2, DSG2, DSC2) and non-desmosomal proteins, and is one of the most common causes of sudden cardiac death in young athletes. Therefore, early identification, correct prevention and treatment can prevent adverse outcomes.Case report. Our case presents a 65-years-old man with recurrent ventricular tachycardia. The ischemic cause was the first to rule out. Echocardiography revealed right ventricular structural and functional abnormalities. After suspicion of ARVC, magnetic resonance imaging was performed showing reduced right ventricular ejection fraction with local aneurysms, structural changes ir the right and left myocardium. Subsequently performed genetic testing identified a novel ARVC likely pathogenic variant in DSC2 gene and variant of uncertain significance in RYR2 gene.Conclusions. Diagnostic evaluation of ARVC is challenging and requires multidisciplinary team collaboration. Further functional tests for elucidation of the clinical significance of the two novel variants of ARVC-associated genes could be suggested.
Uno
Authors: Formato Federica , Tantucci Vittorio 
Published: January 2021

Generic masculines – masculine forms used for women – are employed in many languages, for example English (Mills 2008), French (Coady 2018), Spanish (Bengoechea 2011) and German (Motschenbacher 2016), providing accounts of how gender is made visible in the language through morphological, lexical and syntactic units. These accounts are also linked with how gender is seen in societies and culture, reproducing an imbalance between women and men. Specifically, language discrimination against women is based on the idea that speakers orient themselves towards androcentric language, recognising ‘men’ as a metonym for the group ‘human being’ (Alvanoudi 2014), causing a linguistic invisibility of women. Similarly, studies in Italian have also discussed the use of masculine forms to refer to, talk about and describe women (Cavagnoli 2013), or have shown how these are used in specialised (Nardone 2016, 2018) or media corpora (Formato 2014, 2016, 2019). This article investigates the use of a specific (and underexamined) generic masculine in Italian – namely, the indefinite pronoun uno.m.sg (in comparison with una.f.sg) labelled ‘impersonal masculine’ (Formato 2019:69) – in three subcorpora of the Perugia Corpus (TV, Web and Spoken; Spina 2014). Uno.m.sg is seen as constructing ‘extended intersubjectivity’, that is, the awareness of a general third party (3rdP) acting as the social bearer of the utterance (Tantucci 2013, 2016, 2017a). The results show that the masculine impersonal uno.m.sg is widely used in the three subcorpora and in several functions, confirming that grammatically gendered language is still employed within a ‘masculine as a norm’ order.
The COVID-19 pandemic and plans for economic reopening in Brazil: a documental analysis
Authors: Melo Sousa Brenda Caroline , Pereira de Paiva Miguel Henrique , Alencar Miranda Filho Valberto , Leite Sousa Campelo Eloina Hadigyna , Alves Franco Bravin Andressa , Sobrinho Silva Maria Yanaelle , Brito Rodrigues Ângelo , Tajra Fábio Solon , Guedes Alcoforado Aguiar Bruno 
Published: January 2021

BACKGROUND: In March 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic. In Brazil, the high rate of dissemination made it necessary to adopt restrictive measures nationwide with the discussion regarding the resumption of economic activities starting in April. In mid-December the country had 6,970,034 cases diagnosed and 182,799 deaths from COVID-19.
OBJECTIVE: To analyze the content and characteristics of official documents, which guided the period of transition and resumption of economic activities in Brazil based on health indicators. METHODS: This is a documental research, carried out between May and July 2020, using official websites and publications from the state governments of the 27 federative units in Brazil as sources. In the study, only documents that used epidemiological and health indicators were included as determining criteria for decision making in relation to the easing, permanence or regression of social isolation measures adopted during the COVID-19 pandemic.
FINDINGS: Plans, decrees and technical notes were identified for 18 Brazilian federal units. In most documents, the scientific team was made up exclusively of technicians (n = 10). The number of indicators found ranged from 2 to 11, being stratified into 5 categories: frequency and distribution of the disease; social and collective adherence; installed capacity or service profile; productive potential; and availability of supplies.
MAIN CONCLUSIONS: Knowing governmental strategies, adopted in the easing of restrictive measures, in the face of the coronavirus (SARS-CoV-2) pandemic based on indicators and with the possibility of comparison between different federative units, provides subsidies for understanding the outcome of the disease by place of occurrence, allowing the construction of a panorama pathology in the country. The appropriation of the findings of this study by Brazil and other countries also serves as an instrument for reflection and planning of policies adopted during the COVID-19 pandemic.
Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China
Authors: Li Guoxing , Huang Jing , Wang Jinwei , Zhao Minghui , Liu Yang , Guo Xinbiao , Wu Shaowei , Zhang Luxia 
Published: January 2021

Background
Fine particulate matter (PM2.5) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM2.5 and risk of CKD remains under-recognized, especially in regions with high levels of PM2.5, such as China.

Methods
To explore the association between long-term exposure to ambient PM2.5 and CKD prevalence in China, we used data from the China National Survey of CKD, which included a representative sample of 47,204 adults. We estimated annual exposure to PM2.5 before the survey date at each participant’s address, using a validated, satellite-based, spatiotemporal model with a 10 km×10 km resolution. Participants with eGFR <60 ml/min per 1.73 m2 or albuminuria were defined as having CKD. We used a logistic regression model to estimate the association and analyzed the influence of potential modifiers.

Results
The 2-year mean PM2.5 concentration was 57.4 μg/m3, with a range from 31.3 to 87.5 μg/m3. An increase of 10 μg/m3 in PM2.5 was positively associated with CKD prevalence (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.22 to 1.35) and albuminuria (OR, 1.39; 95% CI, 1.32 to 1.47). Effect modification indicated these associations were significantly stronger in urban areas compared with rural areas, in males compared with females, in participants aged <65 years compared with participants aged ≥65 years, and in participants without comorbid diseases compared with those with comorbidities.

Conclusions
These findings regarding the relationship between long-term exposure to high ambient PM2.5 levels and CKD in the general Chinese population provide important evidence for policy makers and public health practices to reduce the CKD risk posed by this pollutant.
HPTLC Profile of Phenolic Compounds Presents in Extracts Obtained from Different Varieties of White and Red Grape Pomace
Authors: Corina Bubueanu , Ducu Catalin , Tabrea Ioana , Moga Sorin 
Published: January 2021

Grape pomace is used in different areas in the food and food supplement, cosmetic, pharmaceutic industries, and for compost or animal food. The chemical composition is different between white and red grapes varieties, depending also on the sort of wine obtained. Grape pomace contains various chemical compounds from the following classes: phenolics, proteins, minerals, lipids. Our goal was to show the HPTLC fingerprint for quality evaluation and total phenol content for the quantitative evaluation of extracts obtained from 4 varieties of grape pomace (Feteasca regala, Riesling, Burgund, Cabernet Sauvignon). The extracts were obtained by UAE and MAE. The HPTLC fingerprints of the extract shown that there are 4 compounds present in all samples: rutin, hyperoside and, chlorogenic and caffeic acids. In all samples was observed the presence of resveratrol. Total phenol content expressed as gallic (GAE) acid equivalents per 100ml extract were between 4.75% and 13.08%.