bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-Reactive Protein to Albumin Ratio Predicts Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Analysis
Authors: Tada Toshifumi , Kumada Takashi , Hiraoka Atsushi , Hirooka Masashi , Kariyama Kazuya , Tani Joji , Atsukawa Masanori , Takaguchi Koichi , Itobayashi Ei , Fukunishi Shinya , Tsuji Kunihiko , Ishikawa Toru , Tajiri Kazuto , Ochi Hironori , Yasuda Satoshi , Toyoda Hidenori , Hatanaka Takeshi , Kakizaki Satoru , Shimada Noritomo , Kawata Kazuhito , Tanaka Takaaki , Ohama Hideko , Nouso Kazuhiro , Morishita Asahiro , Tsutsui Akemi , Nagano Takuya , Itokawa Norio , Okubo Tomomi , Arai Taeang , Imai Michitaka , Naganuma Atsushi , Aoki Tomoko , Koizumi Yohei , Nakamura Shinichiro , Joko Kouji , Hiasa Yoichi , Kudo Masatoshi 
Published: November 2021

Abstract
We investigated the impact of C-reactive protein to albumin ratio (CAR) on predicting outcomes in 522 patients with unresectable hepatocellular carcinoma (HCC) treated with lenvatinib. We determined the optimal CAR cutoff value with time-dependent receiver operating characteristic curve analysis. Additionally, we clarified the relationship between CAR and liver function or HCC progression. Median overall survival was 20.0 (95% confidence interval (CI), 17.2–22.6) months. The optimal CAR cutoff value was determined to be 0.108. Multivariate analysis showed that high CAR (≥0.108) (hazard ratio (HR), 1.915; 95% CI, 1.495–2.452), Eastern Cooperative Oncology Group performance status ≥1 (HR, 1.429), and α-fetoprotein ≥400 ng/mL (HR, 1.604) were independently associated with overall survival. Cumulative overall survival differed significantly between patients with low versus high CAR (p<0.001). Median progression-free survival was 7.5 (95% CI, 6.7–8.1) months. Multivariate analysis showed that age, CAR ≥0.108 (HR, 1.644; 95% CI, 1.324–2.043), and non-hepatitis B, non-hepatitis C etiology (HR, 0.726) were independently associated with progression-free survival. Cumulative progression-free survival differed significantly between patients with low versus high CAR (p<0.001). CAR values were significantly higher as Japan Integrated Staging score increased (p<0.001). In conclusion, CAR can predict outcomes in patients with unresectable HCC treated with lenvatinib.
Antifungal Effect of Triclosan On Aspergillus Fumigatus: Quorum Quenching Role As A Single Agent And Synergy With Liposomal Amphotericin-B
Authors: Tamimi Roya , Kyazze Godfrey , Keshavarz Tajalli 
Published: November 2021

Abstract
The purpose of this research was to determine Aspergillus fumigatus conidial viability and its biofilm formation upon treatment with triclosan and amphotericin-B loaded liposomes. A. fumigatus was treated with the antimicrobials, triclosan and liposomal amphotericin-B (L-AMB), in single and combined supplementation. To quantify the cells’ viability upon treatments, resazurin-based viability assay was performed. Confocal laser scanning microscopy was done by applying FUN-1 stain to screen the role of the agents on extracellular polymeric substances. Total A. fumigatus biomass upon treatments was estimated by using crystal violet-based assay. To study the agents’ effect on the conidial viability, flow cytometry analysis was performed. Expression levels of A. fumigatus genes encoding cell wall proteins, α-(1,3)-glucans and galactosaminogalactan were analysed by real-time polymerase chain reaction assay. A synergistic interaction occurred between triclosan and L-AMB when they were added sequentially (triclosan+L-AMB) at their sub-minimum inhibitory concentrations, the triclosan and L-AMB MICs were dropped to 0.6 and 0.2 mg/L, respectively, from 2 and 1 mg/L. Besides, L-AMB and triclosan contributed to the down-regulation of α-(1,3)-glucan and galactosaminogalactan in A. fumigatus conidia and resulted in less conidia aggregation and mycelia adhesion to the biotic/abiotic surfaces; A. fumigatus conidia -became hydrophilic upon treatment, as a result of rodlet layer being masked by a hydrophilic layer or modified by the ionic strength of the rodlet layer. In A. fumigatus, the potential mechanisms of action for L-AMB might be through killing the cells and for triclosan through interrupting the cells’ development as a consequence of quorum quenching.
A Retrospective Analysis of the Effects of TIME on Compliance and Driving Pressures in Acute Respiratory Distress Syndrome: The TIMED Study
Authors: Jagan Nikhil , Morrow Lee , Walters Ryan , Plambeck Robert , Ng Ian , Chovatiya Jasmin , Macaraeg Jeffrey , Kalian Karson , Wittenberg Zachariah , Pruett William , Knedler Jonathan , Klein Lauren , Kasinath Pooja , Dyer Emily , Bergh Adam , Malesker Mark 
Published: November 2021

Abstract
Background:The evolution of compliance and driving pressure in acute respiratory distress syndrome (ARDS) and the effects of time spent on noninvasive respiratory support prior to intubation has not been well studied. We conducted this study to assess the effect of the duration of noninvasive respiratory support prior to intubation (i.e., Noninvasive ventilation (NIV), High flow nasal cannula (HFNC), or a combination of NIV and HFNC) on static compliance and driving pressure and retrospectively describe its trajectory over time for COVID-19 and non-COVID-19 ARDS while on mechanical ventilation. Methods: Retrospective analysis of prospectively collected data from one university-affiliated academic medical center, one a rural magnet hospital, and three suburban community facilities. A total of 589 patients were included: 55 COVID-19 positive, 137 culture positive, and 397 culture negative patients. Static compliance and driving pressure were calculated at each 8-hour ventilator check. Results:Days of pre-intubation noninvasive respiratory support was associated with worse compliance and driving pressure but did not moderate any trajectory. COVID-19 positive patients showed non-statistically significant worsening compliance by 0.08-units per ventilator check (p = .241), whereas COVID-19 negative patients who were either culture positive or negative patients showed statistically significant improvement (0.12 and 0.18, respectively; both p < .05); a statistically similar but inverse pattern was observed for driving pressure. ConclusionIn contrast to non-COVID-19 ARDS, COVID-19 ARDS was associated with a more ominous trajectory with no improvement in static lung compliance or driving pressures. Though there was no association between days of pre-intubation noninvasive respiratory support and mortality, its use was associated with worse overall compliance and driving pressure.
Prognostic Prediction of Novel Risk Scores (AML-DRG and AML-HCT-CR) in Acute Myeloid Leukemia Patients with Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Cao Weijie , Li Xiaoning , Zhang Ran , Bian Zhilei , Zhang Suping , Li Li , Xing Haizhou , Liu Changfeng , Xie Xinsheng , Jiang Zhongxing , Yu Jifeng , Wan Dingming 
Published: November 2021

Abstract
Purpose

We aimed to validate and prove the novel risk score models of acute myeloid leukemia (AML)-specific disease risk group (AML-DRG) and AML-Hematopoietic Cell Transplant-composite risk (AML-HCT-CR) in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (AHCT).
Methods

One hundred twenty-three AML (non-APL) patients underwent AHCT was enrolled in this study. Patients were stratified into 3 AML-DRG and 4 AML-HCT-CR risk groups. Of the 123 patients, 57 (46.3%) were females, and the median age was 31 years (range 12 to 62 years). All patients received myeloablative conditioning. Median follow-up was 46 months (range 1 to 94 months). AML-DRG and AML-HCT-CR score models were applied with the overall survival (OS) and progression-free survival (PFS) analysis after the clinical follow-up.
Results

For the AML-DRG model, the 3-year OS in the low, intermediate and high-risk groups were 65.4%, 34.9% and 8.3%, respectively (p<0.001). The corresponding 3-year PFS were 64.0%, 34.9% and 8.3% (p<0.001). The OS predictive accuracy measured by C-index was 0.680. In the AML-HCT-CR model, the 3-year OS in the low, intermediate, high and very high-risk groups were 65.4%, 52.0%, 11.1% and 8.3%, respectively (p<0.001). The corresponding 3-year PFS were 64.0%, 52.0%, 11.1% and 8.3% (p<0.001). The OS predictive accuracy measured by C-index was 0.705. The AML-DRG and AML-HCT-CR models significantly predicted cumulative incidence of relapse (p=0.002; p=0.005). But both scores were not associated with NRM (p=0.314; p=0.095). Univariate analysis showed that the AML-DRG model could better stratify AML patients into different risk groups compared to the AML-HCT-CR model. Multivariate analysis confirmed that prognostic impact of AML-DRG and AML-HCT-CR models on post-transplant OS was independent to age, sex, conditioning type, transplant modality, and stem cell source (p<0.001; p<0.001).
Conclusions

The AML-DRG and AML-HCT-CR models can be used to effectively predict post-transplant survival in patients with AML receiving AHCT in our center. Compared to AML-HCT-CR score, the AML-DRG score allows better stratification and improved survival prediction of AML patients post-transplant.
Extracting Thin-film Optical Parameters from Spectrophotometric Data by Evolutionary Optimization
Authors: Dutta Rajdeep , Tian Siyu Isaac Parker , Liu Zhe , Venkataraj Selvaraj , Cheng Yuanhang , Bash Daniil , Buonassisi Tonio , Jayavelu Senthilnath 
Published: November 2021

Abstract
Extracting optical parameters from spectrophotometric measurements is a challenging task. In a photometric setup, an unknown thin-film is subjected to an incident light beam for a range of admissible wavelengths, which outputs reflectance and transmittance spectra. The current work attempts to solve an inverse problem of extracting thin-film thickness and complex refractive index from reflectance and transmittance spectra for an incident angle of light. The film thickness is a scalar quantity, and the complex refractive index is composed of real and imaginary parts as functions of wavelengths. We leverage evolutionary optimization techniques to solve the underlying inverse problem, which determines the desired parameters associated with two optical dispersion models: ensemble of Tauc-Lorentz (TL) and ensemble of Gaussian oscillators, such that the generated spectra accurately fit the input data. The optimal parameters involved in the adopted models are determined using efficient evolutionary algorithms (EAs). Numerical results validate the effectiveness of the proposed approach in estimating the optical parameters of interest.
Epoch-Making Discovery for CO2 Characteristics: “Pseudo Osmosis” in the Gas Phase
Authors: Sorimachi Kenji 
Published: November 2021

Abstract
Recently, unprecedented torrential rains have deluged the globe, resulting in disastrous floods. These disasters were caused by climate changes because of an increase in carbon dioxide (CO2) concentration in the atmosphere since the industrial revolution. Therefore, atmospheric accumulation of CO2 should be reduced to avoid a future climate crisis. Many methods to fix CO2 have been developed, but a practical method has not been established, except for the method using amines based on moderate plant constructions. However, the membrane method has not yet been established because of the conflicting relationship between penetrability and specificity, although membrane technology can be used for CO2 separation. Epoch-making discoveries for CO2 characteristics have been presented as follows: 1) the high penetrability of CO2 in the gas phase caused “pursued osmosis” against polymer elasticity; 2) highly penetrable CO2 passed through polymer membranes such as authentic polymers and natural cellulose, whereas neither O2 nor N2 penetrates these polymers examined; 3) CO2 is absorbed by plastics; 4) H2 and CH4 gases penetrate through polymer membranes, but their penetration was completely blocked in the presence of water; and 5) using a polytunnel made of polymer sheets (an artificial forest or positive green house), which allows CO2 penetration, instead of hard chamber, steel, or plastic could be cost effective. Therefore, polymer membranes could be practically and economically useful for CO2 separation from the exhaust gas and atmosphere.
Development of a Novel Film Based on Bacterial Nanocellulose Reinforced Gelatin/Guar Gum Containing Honey for Wound Healing Applications
Authors: Nezhadmokhtari Parinaz , Asadi Nahideh , Ghorbani Marjan , Bakhshayesh Azizeh Rahmani Del , Milani Morteza , Akbarzadeh Abolfazl 
Published: November 2021

Abstract
Bacterial nanocellulose (BNC) is a type of 3-dimensionally structured polymer gel produced by Acetobacter that has recently attracted increased interest in wound healing concerns. To produce an effective antibacterial wound dressing, researchers investigated the manufacturing and structural features of honey-infused BNC reinforced gelatin/aldehyde-modified Guar gum films (H/BNC/Ge/AD-GG). Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), mechanical characteristics, water solubility, and degradability were all used to assess the produced films. In addition, the influence of honey addition on the produced films' various properties has been examined. Antibacterial activity, better degradation capability, improved mechanical qualities, and excellent cell adhesion and proliferation by NIH-3T3 fibroblast cells were among the outcomes. The cytotoxicity assay in vitro revealed good cytocompatibility. As a result of the findings, the produced H/BNC/Ge/AD-GG films appear to have a high potential for antibacterial wound dressing applications.
Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition Decline
Authors: WANG Lifang , Zhen Hefu , Sun Yuzhe , Rong Shuang , Li Benchao , Song Zhijie , Liu Zhili , Guo Ruidong , Li Zhiming , Ding Jiahong , Yang Huanming , Xu Xun , Zhang Xiuqing , Sun Haixi , Nie Chao 
Published: November 2021

Abstract
Numerous studies have investigated the risk factors of Alzheimer’s disease (AD), however, AD- risk factors related miRNAs were rarely reported. In this study, AD- risk factor related miRNAs of 119 Chinese individuals (47 AD patients and 62 cognitively normal controls) were investigated. The results showed that education, tea consumption, leisure activity, and social connection were low Body Mass Index (BMI), depression, and smoking were potentially risk factors for AD patients. Moreover, we screened exosome microRNAs (miRNAs) for the aforementioned lifestyle-related factors. Canonical correlation analyses revealed that our clinical observations were correlated with the miRNA expression profile for education, depression, leisure activity, and social connection. Furthermore, we predicted the targets of differentially expressed miRNAs and found that many of them were reported to be involved in the generation and clearance of Amyloid-beta (Aβ), important molecules related to cognition, and disease-activated microglia response to AD. Our results indicated that certain education and depression factors can contribute to AD progression by modulating miRNA expression, implying that preventive interventions might alter AD progression in Chinese patients.
The Significance of Detective Arrhythmia by Using the Long- Term Ecg Monitoring in the Elderly “so Called” Healthy People: A Screening Study
Authors: Xie Rongsheng , Hong Siting , Gao Guoliang , Zhong Jiaoyue , Geng Lixin , Gao Shanlong , Xu Yanli , Diao Meiling , Li Jiaoyan , Li Yuyu , Liang Zhaoguang 
Published: November 2021

Abstract
BackgroundArrhythmias are potential harmful diseases to human beings, especially atrial fibrillation and ventricular arrhythmia, for causing serious consequences such as acute stroke or even sudden cardiac death. Recently the screening of asymptomatic atrial fibrillation by using the long-term ECG monitoring has been widely noticed. The study is to evaluate the significance of detective arrhythmia by using the long-term ECG monitoring in the elderly “so called” healthy people who never have the symptoms of palpitation, short breath or deny previous history of arrhythmia.MethodsWe enrolled a screening study of 1056 participants who were the elderly “so called” healthy people and ready to have a healthy examination from three different communities. They all underwent a long-term ECG monitoring（an adhesive patch）to evaluate cardiac arrhythmia. Inclusion criterias were 1) without any symptoms, 2) age ≥55, and 3) denying previous history of arrhythmia. We excluded patients with prior arrhythmias and who carried the patch for less than one day due to various factors. Then we compared the detected arrhythmia events in the first 24 hours and the total wearing time. ResultsOut of 1056 participants (69.8±12.0 years, 620 males), supraventricular tachycardia (SVT) was present in 538 subjects (44% VS 54%, 24 hours VS after 24 hours, P>0.05), atrial fibrillation (AF) was detected in 69 subjects (75% VS 25%, 24 hours VS after 24 hours, P<0.001), second degree type II atrioventricular block/third degree atrioventricular block (AVB) and sinus arrest were detected in 9 subjects(22% VS 78%, 24 hours VS after 24 hours, P<0.001),ventricular tachycardia was detected in 29 subjects (31% VS 69%, 24 hours VS after 24 hours, P<0.001). The adhesive patch monitor detected 32.10%（339/1056）arrhythmia events over the first 24 hours compared with arrhythmia events over the total wearing time of the devices, 61.08%（645/1056）(P<0.001). ConclusionsThe long-term adhesive patch monitor (APM) can improve the diagnosis of conceal arrhythmias which have high risks for life quality and lifespan in the elderly “so called ” healthy people, and the diagnostic advantage in bradycardia and ventricular arrhythmias are more obvious.
Uncertainty analysis for the data-driven model using Monte Carlo simulations to predict sodium adsorption rate: A case study, Aras, Sepid-Rud, and Karun Rivers in Iran
Authors: Rahnama Elham , Bazrafshan Omolbanin , Asadollahfardi Gholamreza , Samadi Seyed Yaser 
Published: November 2021

Abstract
Water quality management requires a profound understating of future variations of surface and groundwater qualities for assessment and planning for human consumption, industrial, and irrigation purposes. In this regard, mathematical models, such as Box-Jenkins time series models, Bayesian time series models, and data-driven models are available for future prediction of water quality. However, the uncertainty associated with forecasting is one of the main problems of using these models towards water quality and future planning. In the present work, the uncertainty of the Adaptive Neuro-Fuzzy Inference System, based on Fuzzy c-means clustering, (ANFIS-FCMC) (genfis 3) model is quantified to analyze and predict Sodium Adsorption Rate(SAR) of water of Aras, Sepid-Rud, and Karun Rivers by using Monte Carlo simulations. The results indicate the combined standard and the expanded uncertainty simulated for SAR of Aras River water are 0.58 and1.16, respectively, and the gap is 2 .412 ±1.1622. Also, the combined standard and the expanded uncertainty simulated for SAR of Spid-Rud River water were1.11 and 2.22, respectively, and the gap is equal to 2 .235 ±2.22. Furthermore, the combined standard and the expanded uncertainty simulated for SAR of Aras River water are 2.063, and 4.126, respectively, and the gap is 4.79 ±4.126. Finally, the minimum uncertainty happened to predict SAR of Aras River using ANFIS-FCMC (genfis3) model and maximum SAR uncertainty belong to Karun River.
A Novel High-Dimensional Trajectories Construction Network based on Multi-Clustering Algorithm
Authors: Ren Feiyang , Han Yi , Wang Shaohan , Jiang He 
Published: November 2021

Abstract
A novel marine transportation network based on high-dimensional AIS data with a multi-level clustering algorithm is proposed to discover important waypoints in trajectories based on selected navigation features. This network contains two parts: the calculation of major nodes with CLIQUE and BIRCH clustering methods and navigation network construction with edge construction theory. Unlike the state-of-art work for navigation clustering with only ship coordinate, the proposed method contains more high-dimensional features such as drafting, weather, and fuel consumption. By comparing the historical AIS data, more than 220,133 lines of data in 30 days were used to extract 440 major nodal points in less than 4 minutes with ordinary PC specs (i5 processer). The proposed method can be performed on more dimensional data for better ship path planning or even national economic analysis. Current work has shown good performance on complex ship trajectories distinction and great potential for future shipping transportation market analytical predictions.
Label-Free Quantitative Proteomics To Explore The Action Mechanism of The Pharmaceutical Grade Triticum Vulgare Extract In Speeding Up Keratinocytes Healing.
Authors: Morretta Elva , D'Agostino Antonella , Cassese Elisabetta , Maglione Barbara , Petrella Antonello , Schiraldi Chiara , Monti Maria Chiara 
Published: November 2021

Abstract
Plant extracts have shown beneficial properties in skin repair, promoting wound-healing through a plethora of mechanisms. In particular, the poly/oligosaccharidic aqueous extract of Triticum vulgare (TVE), as well as TVE-based products, showed interesting biological assets, fastening wound repair. Indeed, TVE acts in the treatment of tissue regeneration mainly on decubitus and venous leg ulcers. Moreover, on scratched monolayers, TVE prompted HaCat cell migration, correctly modulating the expression of metalloproteases towards a physiological matrix remodeling. Here, using the same HaCat based in vitro scratch model, TVE effect has been investigated thanks to an LFQ proteomic analysis of HaCat secretome and immunoblotting. Indeed, TVE behavior on secreted proteins has not yet been fully deepened and it could be helpful to obtain a comprehensive picture of its bio-pharmacological profile. It is emerged that the TVE treatment induced an up regulation of several proteins in the secretome (to be exact 219) whereas only few were down regulated (to be exact 85). Interestingly, many of the up-regulated proteins are implicated in promoting wound-healing related processes such as modulating cell-cell interaction and communication, cell proliferation and differentiation and prompting cell adhesion and migration.