bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA SLC7A11-AS1 is Upregulated in Colorectal Cancer and Promotes the Proliferation of Cancer Cells by Suppressing the Maturation of miR-34a
Authors: Chang Peijiang , Wang Maosheng 
Published: January 2021

Abstract
Background: LncRNA SLC7A11-AS1 is recently characterized critical player in cancer biology. We analyzed TCGA dataset and observed the upregulation of SLC7A11-AS1 in colorectal cancer (CRC). We therefore analyzed the role of SLC7A11-AS1 in CRC. Methods: Paired CRC and non-tumor tissues were collected from 60 CRC patients and expression of SLC7A11-AS1 in tissues was determined by RT-qPCR. The 60 CRC patients were followed up for 5 years to analyze the prognostic value of SLC7A11-AS1 for CRC. Correlations were analyzed by linear regression. The effects of SLC7A11-AS1 overexpression on the expression of miR-34a precursor and mature miR-34a were analyzed by RT-qPCR. Cell proliferation was analyzed by CCK-8 assay.Result: SLC7A11-AS1 was upregulated in CRC and predicted poor survival. SLC7A11-AS1 and mature miR-34a were inversely correlated, while SLC7A11-AS1 was not significantly correlated with the precursor of miR-34a. In CRC cells, SLC7A11-AS1 overexpression resulted in the reduced level of mature miR-34a, but not miR-34a precursor. Moreover, SLC7A11-AS1 overexpression reduced the inhibitory effects of miR-34a overexpression on cell proliferation. Conclusion: SLC7A11-AS1 may promote the proliferation of cancer cells in CRC by suppressing the maturation of miR-34a.
Influence of bone conduction transducer type and placement on ocular and cervical vestibular evoked myogenic potentials
Authors: Fröhlich Laura , Wilke Maira , Plontke Stefan K. , Rahne Torsten 
Published: January 2021

Abstract
Purpose: Evaluating the effectiveness of different bone conduction (BC) transducers with controlled coupling force to elicit cervical and ocular vestibular evoked myogenic potentials (cVEMPs, oVEMPs) in healthy subjects by comparing response rates, amplitudes, latencies, thresholds and asymmetry ratios.Methods: Prospective experimental study including healthy participants. VEMPs were measured to different stimulation modes; the BC transducer coupling force was controlled to 5.4 (±0.5) Newton. cVEMPs: to bone conducted vibration (BCV) with the B81 transducer on the mastoid; oVEMPs: to BCV with the B81 on the mastoid, BCV with the B81 on the forehead, and BCV with the Mini-Shaker 4810 on the forehead. Air conducted sound (ACS) with insert earphones was used as reference.Results: Data of 24 normal subjects (mean age 25.3 (± 3.0) years) were analyzed. ACS and BCV with the B81on the mastoid evoked cVEMPs in 100% of ears. The highest oVEMP response rates were obtained with the B81 on the mastoid (83 – 92%), the lowest with the B81 on the forehead (17 – 22%). The Mini-Shaker elicited lower response rates (65%) compared to results from the literature without coupling force control and compared to ACS (78 – 87%). Amplitudes were higher for BCV than ACS. ACS and BCV on the mastoid caused higher asymmetry compared to BCV forehead stimulation.Conclusion: The B81 was feasible to elicit VEMPs with mastoid placement and can be used as an approved medical device to measure BCV VEMPs in a clinical set-up. Normative asymmetry values have to be established due to higher variability for mastoid stimulation.
Predictors of School Students’ Leisure-Time Physical Activity: An Extended Trans-Contextual Model Using Bayesian Path Analysis
Authors: Polet Juho J. , Schneider Jekaterina , Hassandra Mary , Lintunen Taru , Laukkanen Arto , Hankonen Nelli , Hirvensalo Mirja , Tammelin Tuija H. , Hamilton Kyra , Hagger Martin S. 
Published: January 2021

Abstract
The present study aimed to examine effects of motivational and social cognition constructs on children’s leisure-time physical activity participation alongside constructs representing implicit processes using an extended trans-contextual model. The study adopted a correlational prospective design. Secondary-school students (N = 502) completed self-report measures of perceived autonomy support from physical education (PE) teachers, autonomous motivation in PE and leisure-time contexts, and social cognition constructs (attitudes, subjective norms, perceived behavioral control), intentions, trait self-control, habits, and past behavior in a leisure-time physical activity context. Five weeks later, students (N = 298) self-reported their leisure-time physical activity participation. Bayesian path analyses supported two key premises of the model: perceived autonomy support predicted autonomous motivation in PE, and autonomous motivation in PE predicted autonomous motivation in leisure time. Both forms of autonomous motivation predicted social cognition constructs and intentions, but did not predict leisure-time physical activity participation. Self-control, attitudes, and past behavior were direct predictors of intentions and leisure-time physical activity participation. Specifying informative priors for key model relations using Bayesian analysis yielded greater precision for some model effects. Findings raise some questions on the predictive validity of the original trans-contextual model, but highlight the value of extending the model to incorporate additional constructs representing non-conscious processes.
Evaluation of Right Myocardial Performance Index of In Vitro Fertilization Fetuses and Spontaneous Pregnancy Fetuses:A Cross-Sectional Study
Authors: Chen Shaoqi , Zhuang Zemin , Chen Qingzi , Du Xiya , Li Weiping , Tan Xuerui 
Published: January 2021

Abstract
Background Whether the in vitro fertilization (IVF) has an effect on the cardiac function of the fetus is very important to evaluate the safety of the technique. The aim of this paper is to establish normal reference range for the fetal right myocardial performance index (RMPI), and compare the reference range between IVF fetuses and spontaneous pregnancy (SP) fetuses by automatic measurement of the RMPI.Methods 371 spontaneous singleton pregnancies (the control group) and 39 singleton pregnancies conceived by IVF (the experimental group) were enrolled into the current study. An automatic measurement system was used to acquire the RMPI. The cardiac function of the two groups was compared by t-test. Results There was no significant difference in normal reference range of RMPI between IVF fetuses and SP fetuses (RMPI 0.42 ±0.05 vs 0.43±0.05). No strong correlation was also noted between RMPI with gestational age and heart rate.Conclusions Normal reference ranges of RMPI of IVF fetuses and SP fetuses were established, and no significant difference between IVF fetuses and SP fetuses in RMPI was found. Thus, these findings may suggest that IVF has little impact on cardiac function of the fetus.
Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus
Authors: Prausmüller Suriya , Resl Michael , Arfsten Henrike , Spinka Georg , Wurm Raphael , Neuhold Stephanie , Bartko Philipp , Goliasch Georg , Strunk Guido , Pavo Noemi , Clodi Martin , Hülsmann Martin 
Published: January 2021

Abstract
Background. Recently, the European Society of Cardiology (ESC) and European Association for the Society of Diabetes (EASD) introduced a new cardiovascular disease (CVD) risk stratification model to aid further treatment decisions in individuals with diabetes. Our study aimed to investigate the prognostic performance of the ESC/EASD risk model in comparison to the Systematic COronary Risk Evaluation (SCORE) risk model and NT-proBNP in an unselected cohort of type 2 diabetes mellitus (T2DM).Methods & Results. A total of 1690 T2DM patients with a 10-year follow up for fatal CVD and all-cause death and a 5-year follow up for CVD and all-cause hospitalizations were analyzed. According to ESC/EASD risk criteria 25 (1.5%) patients were classified as moderate, 252 (14.9%) high, 1125 (66.6%) very high risk and 288 (17.0%) were not classifiable. Both, NT-proBNP and SCORE risk model were associated with 10-year CVD and all-cause death and 5-year CVD and all-cause hospitalizations while the ESC/EASD model was only associated with 10-year all-cause death and 5-year all-cause hospitalizations. NT-proBNP and SCORE showed significantly higher C-indices than the ESC/EASD risk model for CVD death [0.80 vs 0.53, p<0.001; 0.64 vs 0.53, p=0.001] and all-cause death [0.73, 0.66 vs 0.52, p<0.001 for both].The performance of SCORE improved in a subgroup without CVD aged 40-64 years compared to the unselected cohort, while NT-proBNP performance was robust across all groups.Conclusion. The new introduced ESC/EASD risk stratification model performed limited compared to SCORE and single NT-proBNP assessment for predicting 10-year CVD and all-cause fatal events in individuals with T2DM.
Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers
Authors: Andrade Itana Gomes Alves , Suano-Souza Fabiola Isabel , Fonseca Fernando Luiz , Lago Carolina Sanchez Aranda , Sarni Roseli Oselka Saccardo 
Published: January 2021

Abstract
Introduction: Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective: To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods: This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results: Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 ug/L (43.2-57.0) vs 54.6 (45.2-62.6) ug/dL, p=0.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p=0.029] and lower Apo-A-I/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p=0.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC=0.849) and ALT (AUC=0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion: In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.
A social media-based study on the psychological impact of COVID-19 infections in recovered and recovering patients
Authors: Kumar Vikesh , Varshney Mohit , Singh Harmandeep , Singh Amandeep , Baker Julien S. 
Published: January 2021

Abstract
Background and Objective: The WHO has stressed to regularly monitor the mental health of populations during the COVID-19 pandemic. As a result, we conducted this study to examine anxiety and depression among recovered and recovering COVID-19 patients. Methods: An online survey was conducted using a social media platform from 31/05/2020 to 24/06/2020. The study participants were COVID-19 infected individuals who had recovered or still were in the recovery phase from COVID-19. We collected information on demographics, clinical characteristics and physical complications of COVID-19. Anxiety and depressive symptoms were assessed using previously validated tools. Descriptive statistics and logistic regression were applied to analyze the data. Results: 53.4% of respondents reported that they had a fear of getting COVID-19 again. Anxiety and depressive symptoms were present in 71.7% and 97.6% of respondents respectively. Both disorders were present in 71.3% of respondents. The respondents with shorter durations of physical symptoms (< 2 weeks) demonstrated less anxiety (OR = 0.19; 95% CI: 0.05 - 0.67) and depression (OR = 0.03; 95% CI: 0.01 - 0.37). Conclusion: Anxiety and depression appear as common psychological complications in COVID-19 recovering and recovered patients. Longer durations of COVID-19 related physical symptoms were associated with an increased likelihood of anxiety and depression.
Metacognition and emotional regulation as treatment targets in binge eating disorder: a network analysis study
Authors: Aloi Matteo , Rania Marianna , Carbone Elvira Anna , Caroleo Mariarita , Calabrò Giuseppina , Zaffino Paolo , Nicolò Giuseppe , Carcione Antonino , Coco Gianluca Lo , Cosentino Carlo , Segura-Garcia Cristina 
Published: January 2021

Abstract
Background: This study aims to examine the underlying associations between eating, affective and metacognitive symptoms in patients with binge eating disorder (BED) through network analysis (NA), in order to identify key variables that may be considered the target for psychotherapeutic interventions. Methods: One hundred and fifty-five patients with BED completed measures of eating psychopathology, affective symptoms, emotion regulation and metacognition. A cross-sectional network was inferred by means of Gaussian Markov random field estimation using graphical LASSO and extended Bayesian information criterion (EBIC-LASSO), and central symptoms of BED were identified by means of the strength centrality index. Results: Impaired self-monitoring metacognition and difficulties on impulse control emerged as the symptoms with the highest centrality. Conversely, eating and affective features were less central. The centrality stability coefficient of strength was above the recommended cut-off, thus indicating the stability of the network. Conclusions: According to present NA findings, impaired self-monitoring metacognition and difficulties on impulse control are the central nodes in the psychopathological network of BED while eating symptoms appear marginal. If further studies with larger samples replicate these results, metacognition and impulse control could represent new targets of psychotherapeutic interventions in the treatment of BED. In light of this, Metacognitive Interpersonal Therapy (MIT) could be a promising aid in clinical practice to develop an effective treatment for BED.
Ultrasonic welding of magnetic hybrid material systems –316L stainless steel to Ni/Cu/Ni-coated Nd2Fe14B magnets
Authors: Liesegang Moritz , Beck Tilmann 
Published: January 2021

Abstract
The performance of electric sensors is continuously improving due to the demands of modern vehicles and electronic devices. Magnetic sensors are used in a wide field of applications. However, handling and mounting the typical high-performance rare earth permanent magnets are challenging due to their brittleness. A constant magnetic flux is a key property of the magnetic setup in many devices. State-of-the-art adhesive bonding of magnets in devices can cause problems due to the low durability and viscous behaviour of adhesive polymers, as the magnet may change its position and hence, the magnetic flux distribution in the magnetic setup changes.Ultrasonic welding is a powerful technique to join hybrid material systems quickly and reliably, providing high joint strength, even for brittle materials such as glasses, ceramics and rare earth permanent magnets. The latter is being investigated in this work for the first time. The ultrasonic welding process was adapted to join 316L stainless steel, representing potential components of magnetic devices, to Ni/Cu/Ni-coated Nd2Fe14B. In addition to directly joined steel/magnet-hybrids, ductile aluminium and nickel interlayers were used in order to enhance the joint strength.Process parameters were developed and evaluated considering the resulting shear strength of the joints. The highest shear strength of 35 MPa was achieved for 316L/Nd2Fe14B and 316L/Al/Nd2Fe14B, which is more than twice the shear strength of adhesively bonded joints of up to 20 MPa, according to the literature. The functional performance of the hybrid material systems, evaluated by the magnetic flux density of the hybrid material systems was the highest for directly bonded joints, and those with a nickel interlayer, which did not show any losses in comparison to the single magnet in its initial state. Joints with an aluminium interlayer showed losses of 3% and adhesively bonded joints showed losses of 7% of the magnetic flux density.In summary, the results of this work indicate that ultrasonic welding is a suitable technique to improve the production process and performance of magnetic devices.
Improvement of water quality for mass anopheline rearing: Evaluation of the impact of ammonia-capturing zeolite on larval development and adult phenotypic quality
Authors: Akpodiete Nwamaka Oluchukwu , Tripet Frederic 
Published: January 2021

Abstract
BackgroundMalaria vector control approaches that rely on mosquito releases such as the sterile insect technique (SIT) and suppression or replacement strategies relying on genetically modified mosquitoes (GMM) depend on effective mass production of Anopheles mosquitoes. Anophelines typically require relatively clean larval rearing water, and water management techniques that minimise toxic ammonia are key to achieving optimal rearing conditions in small and large rearing facilities. Zeolites are extensively used in closed-system fish aquaculture to improve water quality and reduce water consumption, thanks to their selective adsorption of ammonia and toxic heavy metals. The many advantages of zeolites include low cost, abundance in many parts of the world and environmental friendliness. However, so far, their potential benefit for mosquito rearing has not been evaluated.MethodsThis study evaluated the independent effects of zeolite and daily water changes (to simulate a continuous flow system) on the rearing of An. coluzzii under two feed regimes (powder or slurry feed) and larval densities (200 and 400 larvae per tray). The duration of larval development, adult emergence success and phenotypic quality (body size) were recorded to assess the impact of water treatments on mosquito numbers, phenotypic quality and identification of optimal feeding regimes and larval density for the use of zeolite.ResultsOverall, mosquito emergence, duration of development and adult phenotypic quality was significantly better in treatments with daily water changes. In treatments without daily water changes, zeolite significantly improved water quality at the lower larval rearing density, resulting in higher mosquito emergence and shorter development time. At the lower larval rearing density, the adult phenotypic quality did not significantly differ between zeolite treatment without water changes and those with daily changes. ConclusionsThese results suggest that treating rearing water with zeolite can improve mosquito production in smaller facilities. Zeolite could also offer cost-effective and environmental-friendly solutions for water recycling management systems in larger production facilities. Further studies are needed to optimise and assess the costs and benefits of such applications to Anopheles gambiae s.l. mosquito rearing programmes.
Hyperglycemia, Inflammatory Response and Infarct Size in Obstructive Acute Myocardial Infarction and MINOCA
Authors: Paolisso Pasquale , Foà Alberto , Bergamaschi Luca , Donati Francesco , Fabrizio Michele , Chiti Chiara , Angeli Francesco , Toniolo Sebastiano , Stefanizzi Andrea , Armillotta Matteo , Rucci Paola , Iannopollo Gianmarco , Casella Gianni , Marrozzini Cinzia , Galiè Nazzareno , Pizzi Carmine 
Published: January 2021

Abstract
BackgroundHyperglycemia has been associated with increased inflammatory indexes and larger infarct sizes in patients with obstructive acute myocardial infarction (obs-AMI). In contrast, no studies have explored these correlations in non-obstructive acute myocardial infarction (MINOCA). We investigated the relationship between hyperglycemia, inflammation and infarct size in a cohort of AMI patients that included MINOCA.MethodsPatients with AMI undergoing coronary angiography between 2016 and 2020 were enrolled. The following inflammatory markers were evaluated: C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-platelet ratio (NPR). Myocardial infarct size was measured by peak high sensitivity troponin I (Hs-TnI) levels, left-ventricular-end-diastolic-volume (LVEDV) and left ventricular ejection fraction (LVEF).ResultsThe final study population consisted of 2450 patients with obs-AMI and 239 with MINOCA. Hyperglycemia was more prevalent among obs-AMI cases. In all hyperglycemic patients - obs-AMI and MINOCA - NLR, NPR, and LPR were markedly altered. Hyperglycemic obs-AMI subjects exhibited a higher Hs-TnI (p < 0.001), a larger LVEDV (p = 0.003) and a lower LVEF (p < 0.001) compared to normoglycemic ones. Conversely, MINOCA patients showed a trivial myocardial damage, irrespective of admission glucose levels.ConclusionsOur data confirm the association of hyperglycemic obs-AMI with elevated inflammatory markers and larger infarct sizes. MINOCA patients exhibited modest myocardial damage, regardless of admission glucose levels.
Psychological distress during the initial COVID-19 pandemic in an Italian cohort of people living with HIV: an online survey
Authors: Donne Valentina Delle , Ciccarelli Nicoletta , Massaroni Valentina , Lombardi Francesca , Lamonica Silvia , Borghetti Alberto , Fabbiani Massimiliano , Cauda Roberto , Giambenedetto Simona Di 
Published: January 2021

Abstract
Our aim was to explore the psychological impact of the initial 2019 Coronavirus (COVID-19) pandemic in a cohort of people living with HIV (PLWH), a population at increased risk of psychological distress. PLWH, treated at our unit, responded an online survey. Data on demographics, clinical and physical symptoms, contact history, as well as knowledge, concerns, precautionary measures and additional information required with respect to COVID-19 during the first phase of the pandemic in Italy were collected. Additionally, the Impact of Event Scale-Revised (IES-R) (identifying COVID-19 pandemic as specific traumatic life event) and the Depression, Anxiety and Stress Scale (DASS-21) were also administered. Out of 98 participants, 44 (45%) revealed from mild to severe psychological impact distress from COVID-19 according to IES-R. According to DASS-21, a lower percentage of significant levels of depression (14%), anxiety (11%) or stress (6%) were reported. Higher education, unemployment, number of perceived physical COVID-19 symptoms, concerns contracting COVID-19 and the situation regarding the pandemic in Italy, and the need of additional information to prevent COVID-19 infection were positively associated to psychological distress. Moreover, female gender, older age, recent HIV diagnosis and unawareness of own viremia were associated to a higher psychological distress. Almost half of our cohort experienced significant levels of distress related to the COVID-19 pandemic. Women, elderly patients and those with recent HIV diagnosis resulted to be the more psychological fragile subgroup. Our findings could help to identify patients in need of psychological interventions to improve wellbeing of PLWH.