bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping manifestations of parametric uncertainty in projected pelagic oxygen concentrations back to contemporary local model fidelity
Authors: Löptien U. , Dietze H. , Preuss R. , Toussaint U. V. 
Published: October 2021

AbstractPelagic biogeochemical models (BGCMs) have matured into generic components of Earth System Models. BGCMs mimic the effects of marine biota on oceanic nutrient, carbon and oxygen cycles. They rely on parameters that are adjusted to match observed conditions. Such parameters are key to determining the models’ responses to changing environmental conditions. However, many of these parameters are difficult to constrain and constitute a major source of uncertainty in BGCM projections. Here we use, for the first time, variance-based sensitivity analyses to map BGCM parameter uncertainties onto their respective local manifestation in model entities (such as oceanic oxygen concentrations) for both contemporary climate and climate projections. The mapping effectively relates local uncertainties of projections to the uncertainty of specific parameters. Further, it identifies contemporary benchmarking regions, where the uncertainties of specific parameters manifest themselves, thereby facilitating an effective parameter refinement and a reduction of the associated uncertainty. Our results demonstrate that the parameters that are linked to uncertainties in projections may differ from those parameters that facilitate model conformity with present-day observations. In summary, we present a practical approach to the general question of where present-day model fidelity may be indicative for reliable projections.
Evidence for the formation of two types of oxygen interstitials in neutron-irradiated α-Al2O3 single crystals
Authors: Lushchik A. , Kuzovkov V. N. , Kotomin E. A. , Prieditis G. , Seeman V. , Shablonin E. , Vasil’chenko E. , Popov A. I. 
Published: October 2021

AbstractDue to unique optical/mechanical properties and significant resistance to harsh radiation environments, corundum (α-Al2O3) is considered as a promising candidate material for windows and diagnostics in forthcoming fusion reactors. However, its properties are affected by radiation-induced (predominantly, by fast neutrons) structural defects. In this paper, we analyze thermal stability and recombination kinetics of primary Frenkel defects in anion sublattice − the F-type electronic centers and complementary oxygen interstitials in fast-neutron-irradiated corundum single crystals. Combining precisely measured thermal annealing kinetics for four types of primary radiation defects (neutral and charged Frenkel pairs) and the advanced model of chemical reactions, we have demonstrated for the first time a co-existence of the two types of interstitial defects – neutral O atoms and negatively charged O- ions (with attributed optical absorption bands peaked at energies of 6.5 eV and 5.6 eV, respectively). From detailed analysis of interrelated kinetics of four oxygen-related defects, we extracted their diffusion parameters (interstitials serve as mobile recombination partners) required for the future prediction of secondary defect-induced reactions and, eventually, material radiation tolerance.
Meta-analysis of the normal diffusion tensor imaging values of the median nerve and how they change in carpal tunnel syndrome
Authors: Rojoa Djamila , Raheman Firas , Rassam Joseph , Wade Ryckie G. 
Published: October 2021

AbstractCarpal tunnel syndrome (CTS) leads to distortion of axonal architecture, demyelination and fibrosis within the median nerve. Diffusion tensor imaging (DTI) characterises tissue microstructure and generates reproducible proxy measures of nerve ‘health’ which are sensitive to myelination, axon diameter, fiber density and organisation. This meta-analysis summarises the normal DTI values of the median nerve, and how they change in CTS. This systematic review included studies reporting DTI of the median nerve at the level of the wrist in adults. The primary outcome was to determine the normal fractional anisotropy (FA) and mean diffusivity (MD) of the median nerve. Secondarily, we show how the FA and MD differ between asymptomatic adults and patients with CTS, and how these differences are independent of the acquisition methods. We included 32 studies of 2643 wrists, belonging to 1575 asymptomatic adults and 1068 patients with CTS. The normal FA was 0.58 (95% CI 0.56, 0.59) and the normal MD was 1.138 × 10–3mm2/s (95% CI 1.101, 1.174). Patients with CTS had a significantly lower FA than controls (mean difference 0.12 [95% CI 0.09, 0.16]). Similarly, the median nerve of patients with CTS had a significantly higher mean diffusivity (mean difference 0.16 × 10–3 mm2/s [95% CI 0.05, 0.27]). The differences were independent of experimental factors. We provide summary estimates of the normal FA and MD of the median nerve in asymptomatic adults. Furthermore, we show that diffusion throughout the length of the median nerve becomes more isotropic in patients with CTS.
Intestinal, liver and lipid disorders in genetically obese rats are more efficiently reduced by dietary milk thistle seeds than their oil
Authors: Opyd Paulina M. , Jurgoński Adam 
Published: October 2021

AbstractWe hypothesized that milk thistle seed or seed oil dietary supplementation reduces intestinal, liver and lipid disorders specific to genetic obesity, and the seeds can be more efficient in doing so. Lean and obese male Zucker rats were allocated to 4 groups: the lean (LC) and obese control (OC) groups fed a standard diet and the other 2 obese groups fed a diet supplemented with milk thistle seed oil (O + MTO) or milk thistle seeds (O + MTS). After 5 weeks of feeding, the cecal SCFA pool was slightly and significantly lower in OC and O + MTO compared with LC and O + MTS. The liver fat content was greater in OC, O + MTO and O + MTS compared with LC; however, it was significantly lower in O + MTS than in OC and O + MTO. The plasma cholesterol was greater in OC compared with LC, O + MTO and O + MTS; however, it was significantly greater in O + MTO and O + MTS compared with LC. The plasma bilirubin was detected in OC and O + MTO, whereas it was not present in LC and O + MTS. Milk thistle seeds can improve fermentation events in the distal intestine and reduce other disorders specific to genetically obese rats, and the seed PUFAs are responsible for that to a lesser extent.
Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data
Authors: Asanomi Yuya , Shigemizu Daichi , Akiyama Shintaro , Sakurai Takashi , Ozaki Kouichi , Ochiya Takahiro , Niida Shumpei 
Published: October 2021

AbstractThere are many subtypes of dementia, and identification of diagnostic biomarkers that are minimally-invasive, low-cost, and efficient is desired. Circulating microRNAs (miRNAs) have recently gained attention as easily accessible and non-invasive biomarkers. We conducted a comprehensive miRNA expression analysis of serum samples from 1348 Japanese dementia patients, composed of four subtypes—Alzheimer’s disease (AD), vascular dementia, dementia with Lewy bodies (DLB), and normal pressure hydrocephalus—and 246 control subjects. We used this data to construct dementia subtype prediction models based on penalized regression models with the multiclass classification. We constructed a final prediction model using 46 miRNAs, which classified dementia patients from an independent validation set into four subtypes of dementia. Network analysis of miRNA target genes revealed important hub genes, SRC and CHD3, associated with the AD pathogenesis. Moreover, MCU and CASP3, which are known to be associated with DLB pathogenesis, were identified from our DLB-specific target genes. Our study demonstrates the potential of blood-based biomarkers for use in dementia-subtype prediction models. We believe that further investigation using larger sample sizes will contribute to the accurate classification of subtypes of dementia.
West Nile virus seroprevalence and associated risk factors among horses in Egypt
Authors: Selim Abdelfattah , Megahed Ameer , Kandeel Sahar , Alouffi Abdulaziz , Almutairi Mashal M. 
Published: October 2021

AbstractDetermination of the seroprevalence and risk factors that are associated with West Nile virus (WNV) in horses is essential for adoption of effective prevention strategies. Our objective in this study, therefore, was to determine the seroprevalence and to identify the risk factors associated with WNV infection in the most densely horse-populated governorates in Egypt. A cross-sectional study was conducted in 2018 on 930 horses, which were distributed over five governorates in the Nile delta of Egypt. The horses, which were randomly selected, were serologically tested through use of an ID screen West Nile competition enzyme-linked immunosorbent assay (ELISA) to detect anti-WNV immunoglobulin G (IgG) and plaque reduction neutralization tests (PRNT; gold standard) to confirm the seropositive status of animals and to avoid cross reaction with other flavi-viruses. Four variables (geographical location, breed, sex and age) were considered in the risk analysis. Univariable and stepwise forward multivariable logistic regression methods were used for risk-factor analysis. The odds ratio (OR) was used as an approximate measure of relative risk. A total of 156 (16.8%; 95% confidence interval (CI) 14.4–19.2; P < 0.001) serum samples were found to be serologically positive for WNV. The highest seroprevalence rate was detected in horses of age ≥ 15 years (68.1%; 95% CI 49.8–72.4), stallions (26.4%; 95% CI 22.7–30.4), and those of mixed breed (21.5%; 95% CI 17.7–27.5). Horses older than 15 years were found to be at increased risk of WNV infection with OR = 4.3 (95% CI 3.0–6.2, P < 0.001) compared with horses aged under 2.5 years. Also, when all the risk factors were considered, stallions were more likely than mares to be WNV seropositive (OR = 2.4, 95% CI 1.6–3.7, P < 0.001), and of the breeds, mixed-breed (OR = 1.9, 95% CI 1.2–2.8, P = 0.005) and Arabian horses (OR = 1.9, 95% CI 1.2–2.8, P = 0.005) were more likely to be seropositive. Geographical location seemed to have no impact on the seroprevalence of exposure to WNV among these horses. Due to these findings, we strongly recommend intensive surveillance and implementation of effective control and prevention strategies against WNV, especially in stallion, mixed-breed horses with ages ≥ 15 years.
Assessment on the oil accumulation by knockdown of triacylglycerol lipase in the oleaginous diatom Fistulifera solaris
Authors: Maeda Yoshiaki , Watanabe Kahori , Kaha Marshila , Yabu Yusuke , Yoshino Tomoko , Matsumoto Mitsufumi , Tanaka Tsuyoshi 
Published: October 2021

AbstractMicroalgae are promising producers of biofuel due to higher accumulation of triacylglycerol (TAG). However, further improvement of the lipid metabolism is critical for feasible application of microalgae in industrial production of biofuel. Suppression of lipid degradation pathways is a promising way to remarkably increase the lipid production in model diatoms. In this study, we established an antisense-based knockdown (KD) technique in the marine oleaginous diatom, Fistulifera solaris. This species has a capability to accumulate high content of lipids. Tgl1 KD showed positive impact on cell growth and lipid accumulation in conventional culture in f/2 medium, resulting in higher oil contents compared to wild type strain. However, these impacts of Tgl1 KD were slight when the cells were subjected to the two-stage growth system. The Tgl1 KD resulted in slight change of fatty acid composition; increasing in C14:0, C16:0 and C16:1, and decreasing in C20:5. This study indicates that, although Tgl1 played a certain role in lipid degradation in F. solaris, suppression of only a single type of TAG lipase was not significantly effective to improve the lipid production. Comprehensive understanding of the lipid catabolism in this microalga is essential to further improve the lipid production.
Classification of temporomandibular joint internal derangement based on magnetic resonance imaging and clinical findings of 435 patients contributing to a nonsurgical treatment protocol
Authors: Hegab Ayman F. , Al Hameed Hossam IAbd , Karam Khaled Said 
Published: October 2021

AbstractThis prospective clinical study aimed to establish a new classification system for TMJ internal derangement based on MRI in correlation with clinical findings contributing to a nonsurgical treatment protocol. A consecutive sample of 435 internal derangement patients was enrolled in the study. Clinical and MRI studies were used to establish the new classification system. A total of 747 joints were classified according to our staging system and received treatment according to the associated nonsurgical treatment protocol. The primary outcome variables were maximum voluntary mouth opening and visual analogue scale pain scores. The secondary outcome variable was joint sound. Statistical analysis of the differences between pretreatment and posttreatment measurements showed an increase in mouth opening throughout the study period (P < 0.001 at 12 m posttreatment). Statistical analysis of the VAS scores showed a statistically significant decrease in all study groups during all study periods, with P < 0.0001 at 12 months posttreatment. Statistical analysis of joint sounds showed significant improvement during all study periods. The new classification system is a simple, & reasonable including a detailed description of all the pathologic changes of the joint. The nonsurgical treatment protocol was Simple, effective and specific depending on the pathological changes in joint.
Influence of gender and education on cocaine users in an outpatient cohort in Spain
Authors: Requena-Ocaña Nerea , Flores-Lopez María , Martín Alicia San , García-Marchena Nuria , Pedraz María , Ruiz Juan Jesús , Serrano Antonia , Suarez Juan , Pavón Francisco Javier , de Fonseca Fernando Rodríguez , Araos Pedro 
Published: October 2021

AbstractGender significantly influences sociodemographic, medical, psychiatric and addiction variables in cocaine outpatients. Educational level may be a protective factor showing less severe addictive disorders, longer abstinence periods, and better cognitive performance. The aim was to estimate gender-based differences and the influence of educational level on the clinical variables associated with cocaine use disorder (CUD). A total of 300 cocaine-consuming patients undergoing treatments were recruited and assessed using the Psychiatric Research Interview for Substance and Mental Diseases according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Women developed CUD later but exhibited more consumption of anxiolytics, prevalence of anxiety disorders, eating disorders, and major depressive disorders. Alcohol and cannabis use disorders were more frequent in men. A predictive model was created and identified three psychiatric variables with good prognosis for distinguishing between women and men. Principal component analysis helped to describe the different profile types of men and women who had sought treatment. Low educational levels seemed to be a risk factor for the onset, development, and duration of CUD in both genders. Women and men exhibited different clinical characteristics that should be taken into account when designing therapeutic policies. The educational level plays a protective/risk role in the onset, development and progression of CUD, thus prolonging the years of compulsory education and implementing cognitive rehabilitation programmes could be useful.
Decision support systems halve fungicide use compared to calendar-based strategies without increasing disease risk
Authors: Lázaro Elena , Makowski David , Vicent Antonio 
Published: October 2021

AbstractThe European Green Deal aims to reduce the use of chemical pesticides by half by 2030. Decision support systems are tools to help farmers schedule fungicide spraying based on disease risk and can reduce fungicide application frequency and overall use. However, the potential benefit of decision support systems compared to traditional calendar-based strategies has not yet been rigorously quantified. Here we synthesise 80 experiments and show that globally decision support systems can reduce fungicide treatments by at least 50% without compromising disease control. For a given fixed number of fungicide sprays, decision support systems were as effective as calendar-based programs in reducing disease incidence. When the number of sprays was halved, the increase in disease incidence was lower for decision support system-based strategies than calendar-based strategies. Our findings suggest that decision support systems can reduce fungicide use while limiting the risk to plant health and resistance development.
How Do You Do Talk Therapy With Someone Who Can't Talk? Perspectives From Mental Health Providers on Delivering Services to Individuals With Aphasia
Authors: Strong Katie A. , Randolph Jenna 
Published: October 2021

Purpose
Aphasia is correlated with depression and anxiety, and it has a negative impact on quality of life. Aphasia is also frequently misunderstood among mental health care providers. The aim of this study was to explore the experiences of mental health providers who provide services to people living with aphasia.

Method
Interpretative phenomenological analysis was used to analyze interviews of six mental health providers who had some experience in providing services to people with aphasia.

Results

Three main themes among mental health care providers' experiences providing services to people with aphasia were identified: barriers, interprofessional collaboration, and therapy looks different. Subthemes associated with
barriers
included insufficient training and knowledge of aphasia, the stigma of receiving mental health services, and accessibility to services. Subthemes related to
interdisciplinary collaboration
included referrals, knowledge and awareness, and strategies and tools. Subthemes supporting
therapy looks different
included a new approach to therapy and challenges.

Conclusions
Mental health providers' experiences reveal the need for an action-oriented approach to overcome barriers, a nontraditional approach to talk therapy for people with aphasia, and increased collaboration with speech-language pathologists (SLPs). Future research should explore expanding the collaboration between SLPs and mental health providers to increase shared knowledge and skills in issues related to reducing depression and anxiety to support the well-being of people with aphasia.
Phonological Development in Urdu-Speaking Children: A Systematic Review
Authors: Ambreen Saira , To Carol K. S. 
Published: October 2021

Background
Speech and language researchers study phonological acquisition and evaluate the errors that children make to understand this complex process. This information provides clinicians with a scientific reference for better assessment and intervention services to children with articulation/phonological disorders. Urdu is a language spoken by more than 200 million speakers worldwide. However, research on Urdu phonological development is in its infancy.

Purpose
This systematic review aimed to identify relevant studies and provide a comprehensive review of which aspects of Urdu phonological development have been targeted, along with the reported findings.

Method
Five phases of the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines were followed. All retrieved studies published between January 1980 and March 2020 and focusing on Urdu speech sound acquisition and/or phonological processes in typically developing native Urdu speakers aged up to 8 years were included in the review. The final search was conducted on May 4, 2020.

Results
A total of 873 records were identified from five databases and a manual search. Nine studies fulfilling the inclusion criteria were included in the final review. All studies were published in the English language, five of which were unpublished master's theses and four were peer-reviewed journal articles. Four of these studies focused on consonant acquisition, whereas five explored phonological processes. No study focused on the acquisition of Urdu vowels, diphthongs, or consonant clusters. These shortlisted studies were reviewed in detail to determine participants' demographic characteristics, focused areas of phonological acquisition, data elicitation methods and contexts, transcription systems, and major findings.

Conclusion
This study provides a comprehensive review of the available literature on Urdu phonological development and highlights areas for future research.
Adaptive sliding mode synchronisation for fractional‐order non‐linear systems in the presence of time‐varying actuator faults
Authors: Bataghva Meysam , Hashemi Mahnaz 
Published: October 2021

AbstractThis paper presents an adaptive sliding mode synchronisation scheme for a class of fractional order non‐linear systems in the presence of unknown parameters, actuator faults and disturbances. The designed adaptive controller compensates a general class of actuator faults without the need for any explicit fault detection. The parameters, times and patterns of the considered faults are completely unknown. The proposed adaptive sliding mode synchronisation scheme can guarantee the asymptotic convergence of the synchronisation errors to the origin despite the presence of actuator faults and uncertainties. The simulation results show the correctness and effectiveness of the proposed adaptive sliding mode fault compensation approach.
Control strategy for direct voltage and frequency stability enhancement in HVAC/HVDC grids
Authors: Azizi Neda , Moradi CheshmehBeigi Hassan , Rouzbehi Kumars 
Published: October 2021

AbstractDirect voltage fluctuations due to the presence of relatively large DC reactors (as an essential part of HVDC breakers), lack of inertia, and unwanted frequency fluctuations in the AC side of HVDC grids, have major consequences on the stability of HVAC/HVDC grids. The use of the DC Power System Stabilizer (DC‐PSS) can damp and eliminate voltage oscillations caused by the presence of the DC reactors. However, DC‐PSS cannot address the issues of inertia and unwanted frequency fluctuations. A method to improve inertia is proposed here that can operate well with the droop controller, and DC‐PSS does not interfere with power‐sharing and does not interact with any of these elements. Since the presence of a droop controller in HVAC/HVDC grids associates with power and direct voltage, the method proposed here can improve direct voltage fluctuations by eliminating severe power peaks. Moreover, this method does not change the voltage level of the entire system, so there is no need to change the set‐points of controllers. In addition, all parameters of the controllers are tuned by an intelligent algorithm, and the Participation factor (PF) scheme is used to find the proper placement of the proposed controller.