bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study the Prevalence of Depression in Patients Attending Comprehensive Care Centre, Islamabad, Pakistan
Authors: Nimra Mehak , Yousaf Sobia , Naz Huma , Nain Hira , Shahid Tahreem , Amber Adeela , Aman Faseeha 
Published: September 2021

Abstract:
Depression is one of the most common neuropsychiatric complications of HIV disease, and this leads to worse HIV-related health outcomes. With 350 million people affected worldwide, rates of depression are roughly two times greater in people living with HIV than in the general population.
Objective: Determine prevalence of depression in patients attending Comprehensive Care Centre Shifa international Hospital, Islamabad
Design: Descriptive cross-sectional quantitative study.
Settings: Shifa international Hospital, Islamabad Comprehensive Care Centre,
Methods: This data is from a bigger study ‘prevalence of alcohol use disorders and depression in patients attending Comprehensive Care Centre (CCC). The study population consisted of PLWHA attending the CCC. Two hundred and seventy-two (N=272) participants from CCC attendants were recruited. All consenting male and female aged 18-65 years were interviewed using the researcher’s designed questioner to collect their socio-demographic characteristics. Fully completed questionnaires were entered into excel sheets and analyzed using the Statistical Package for Social Sciences (SPSS) Version 20.
Results: The overall prevalence of depression was 23.8%, with mild depression at 9.7%, moderate depression at 10.4% and severe depression accounting for 3.7%, respectively. Depression was associated with alcohol use (p=0.024). A significant difference between depression and age where depression levels worsens as age advances; respondents in age category of 18-21 years had less or no depression compared to those in the age category of 33 years and above. We found an association between depression and employment. Those laid-off work (1/3), and the retired (15%) had more depression compared to the employed (11%) or self-employed 6%, with a P value of 0.55 (borderline). On multivariate analysis severity of depression (OR=5.5, 95% CI of OR [2.1 –14.3], p<0.0001) was associated with male gender (OR=10, 95% CI of OR [3.6 –28.3], p<0.0001).
Conclusion: The study findings indicate a high prevalence of depressive symptoms in patients attending the CCC. There is need to set-up appropriate interventions and strategies to reduce the prevalence of mental health disorders into routine HIV clinical care and support.
Weed Management under Phosphorus Enrichment in Groundnut (Arachis hypogaea L.)
Authors: Jat Harikesh , Kaushik M.K. , Sharma S.K. , Meena V.K. 
Published: September 2021

Background: Weeds infestation is one of the major threats to crop production and leads to severe crop-weed competition which finally reduce the crop productivity in term of quality and quantity. To enhance crop productivity therefore efficacy of various pre and post-emergence herbicides were evaluated on the basis of Amaranthus viridis, Commelina benghalensis and Cynodon dactylon population reduction, nutrient concentration and their uptake by groundnut.
Methods: The present investigation was conducted consecutively for two kharif seasons of 2016 and 2017, at Instructional Farm, CTAE, MPUAT, Udaipur with six weed management practices and four phosphorus levels thus, 30 treatment combinations; all were evaluated in split-plot design with three replications. Result: The experimental results revealed that all herbicidal treatments as well as weed free recorded significantly lowest weed density as well as highest weed control efficiency, nitrogen, phosphorus and potassium concentration and also their uptake by groundnut as compared to weedy check except quizalofop-ethyl at 30 DAS in respect to control Cynodon dactylon. Further, pod yield response to phosphorus was found quadratic. The results also showed that phosphorus exhibit significantly increase nutrients concentration and their uptake by groundnut over control during the experimentation.
Perhitungan sumberdaya batubara di wilayah IUP Operasi Produksi PT Angsana Jaya Energi, Provinsi Kalimantan Selatan
Authors: Firdaus Akmal , Saismana Uyu , Hakim Romla Noor 
Published: September 2021

CV Inti Mitra Gemilang merupakan perusahaan jasa eksplorasi dan pemboran yang melakukan kerjasama kemitraan dengan pemilik kuasa pertambangan PT Angsana Jaya Energi yang berlokasi Desa Bayansari, Kecamatan Angsana, Kabupaten Tanah Bumbu, Provinsi Kalimantan Selatan. Penelitian ini menghitung sumberdaya batubara menggunakan metode circular dimana sumberdaya terbagi menjadi tiga yaitu terukur dengan jarak 250m, tertunjuk dengan jarak 500m, dan tereka dengan jarak 1000m. Hasil permodelan batubara menunjukkan sebaran batubara mengarah ke timur laut - barat daya dengan strike sebesar N140°E dengan arah kemiringin sebesar N230°E dan dip berkisar antara 35°. Hasil korelasi batubara menunjukkan sumberdaya batubara terdiri dari 3 seam yaitu seam A, B dan C dengan rata-rata ketebalan berturut-turut antara lain 3,7m, 5,57m, dan 0,58m. Permodelan seam A dan seam B mengalami percabangan ke arah barat daya dengan rata-rata ketebalan antara lain seam A1 sebesar 2,16m, seam A2 sebesar 2,99m, seam B1 sebesar 1,5m, dan seam B2 sebesar 1,82m. Berdasarkan hasil estimasi diperoleh volume dan luasan untuk masing-masing sumberdaya sebagai berikut: tereka sebesar 10.188.425 ton dan 102,21 Ha, tertunjuk sebesar 4.219.062,62 ton dan 73.36 Ha, dan terukur sebesar 122.746.259 ton dan 616,44 Ha. Kata-kata kunci: eksplorasi, permodelan, estimasi
Perancangan Konstruksi Profil Pada Kapal General Cargo Dengan Menggunakan Metode Ship Comparative
Authors: Japri Rahmahdani 
Published: September 2021

Kapal general cargo adalah kapal yang mengangkut bermacam-macam muatan berupa barang. Barang yang diangkut biasanya merupakan barang yang sudah dikemas. Ukuran utama kapal didapatkan dengan menggunakan metode pembanding regresi yang didasarkan pada data 2 kapal pembanding yang di dapat dari korea register of shipping (KRS). Pada penelitian ini direncanakan desain konstruksi profil kapal general cargo yang dirancang sesuai dengan ukuran utama kapal yang sesui dengan aturan Rules Biro klasifikasi Indonesia. Dari hasil perencanaan didapat untuk kapal berkapasitas 17000 DWT didapat dimensi kapal dengan length over all (LOA) 153,45 m, length between prependiculars (LBP) 144,24 m, Length on load waterline (LWL) 147,85 m, lebar (B) 25,27 m, tinggi (H) 13,5 m, sarat (T) 9,52 m, kecepatan (V) 14,75 Knot. Metode pembanding ini memudahkan perancangan kapal dengan hasil yang lebih akurat.
Peranan Kantor Urusan Agama dalam Mengatasi Perkawinan Dibawah Tangan
Authors: Gibran Ananda Muhammaad Khalil 
Published: September 2021

<p>Kebanyakan orang meyakini bahwa perkawinan dibawah tangan dianggap sah menurut hukum islam apabila telah memenuhi rukun dan syarat-syartnya, sekalipun perkawinan tersebut tidak dicatakan di Kantor Urusan Agama (KUA). Akibat dari pemahaman tersebut timbulah dualisme hukum yang ada di negara Indonesia ini, yaitu disatu sisi perkawinan itu harus dicatatkan di Kantor Urusan Agama dan disisi lain perkawinan tanpa dicatatpun tetap berlaku dan diakui oleh masyarakat. Penelitian ini bertujuan untuk mengetahui dan menganalisis tentang peranan Kantor Urusan Agama dalam mengatasi perkawinan dibawah tangan dan untuk mengetahui kendala apa saja yang dihadapi Kantor Urusan Agama dalam mengatasi perkawinan dibawah tangan. Penelitian ini menggunakan hukum sosiologis atau empiris biasa juga disebut dengan penelitian lapangan. Sumber data yang digunakan adalah sumber data primer dan sekunder. Hasil Penelitian menunjukan bahwa Peranan Kantor Urusan Agama (KUA) Pasar Kliwon Surakarta dalam mengatasi perkawinan dibawah tangan meliputi, <em>Pertama</em> melakukan kegiatan penyuluhan terkait Pencatatan Pernikahan dan Keluarga Bahagia yang dilakukan oleh Badan Penasehat Pembinaan dan Pelestarian Perkawinan (BP4) di Kantor Urusan Agama (KUA) kepada calon pengantin, <em>Kedua </em>menggencarkan sosialisasi manfaat pencatatan pernikahan dan dampak negatif terkait keberlangsungan keluarganya kelak melalui pengajian yang diselenggarakan oleh Departemen Agama di tingkat kecamatan. Kendala yang dialami oleh Kantor Urusan Agama (KUA) dalam mengatasi perkawinan dibawah tangan di Kecamatan Pasar Kliwon adalah, <em>Pertama </em>karena adanya Anggapan Masyarakat Bahwa Pencatatan perkawinan di KUA Hanya Sekedar Pencatatan Adminstrasi saja, <em>Kedua </em>Perkawinan dibawah tangan dianggap cukup dan diakui oleh masyarakat sekitar</p>
Isolation and Identification of Fungi from Clinical Samples of Diabetic Patients and Studying the Anti-Fungal Activity of Some Natural Oils on Isolated Fungi
Authors: Abomughaid Mosleh Mohammad 
Published: September 2021

Isolation of fungi was performed from February to July, 2019. One hundred clinical specimens were collected from King Abdullah Hospital (KAH) Bisha, Saudi Arabia. Samples were collected from twenty patients of different ages (30 - 70 years old) ten males and ten females. The samples were collected from patients with the two types of diabetics. Specimens included blood, hair, nail, oral swabs and skin. Specimens were inoculated on Sabourauds Dextrose agar containing chloramphenicol. Thirteen fungal species were isolated and identified. The isolated species were: Aspergillus flavus, A. niger, A. terrus, A. nidulans, A. fumigatus, Candida albicans, C. krusei, C. parapsilosis, C. Tropicalis, Curvularia lunata, Fusarium solani, Penicillium marneffei and Saccharomyces cerevisiae. Identification of molds was carried out morphologically and microscopically using available methods and books of identification, while identification of yeasts was carried out using API system. C. albicans recorded the highest isolated number where 31 colonies were isolated from 18 patients, representing relative density of 22.5%. (R. D.: is the number of a certain fungal species divided by the total number of fungi). Other isolated fungal species recorded relative density less than 16 %. The most common isolated fungus Candida albicans was molecularly identified using the 5.8S and flanking ITS regions. The antifungal activity of some natural essential oils (cinnamon, thyme, coconut, almond and clove) was assayed against isolated fungi using disk diffusion method. The used concentration was 5 µl / plate. The MIC values were also determined using different oil concentrations (1, 2.5, 5, 10, 20 and 40 µl / disc).
A Path Analysis to Investigate the Interaction between Serum, Urinary and Demographic Factors Influencing Urine Calcium in Kidney Stone Formers
Authors: Taheri Fatemeh , Taheri Maryam , Tavasoli Sanaz , Borumandnia Nasrin , Basiri Abbas 
Published: September 2021

Abstract
Background: Hypercalciuria is one of the most important urinary risk factors in kidney stone formers. This study aimed to delineate the interaction of some demographic, serum, and urinary risk factors influencing 24-hour urinary (24-U) calcium excretion.Methods: This study was secondary data analysis, using data from 593 kidney stone patients referred to the Labbafinejad kidney stone prevention clinic from March 2015 to May 2019. The study considered serum, urinary and demographic factors that interact to influence 24-U calcium using path analysis.Results: The results showed that age and weight had an indirect effect on 24-U calcium. Among serum variables, PTH and creatinine had a significant direct effect on 24-U calcium. In comparison, 25-hydroxy vitamin D (25(OH)D) and phosphorus appeared to influence 24-U calcium through serum parathormone. Regarding 24-U metabolites, 24-U sodium, 24-U Urea, and 24-U citrate had a significant direct effect on 24-U calcium. Moreover, 24-U creatinine has a significant direct and indirect effect on 24-U calcium through 24-U citrate and 24-U Urea as mediating variables. 24-U citrate had the most effect on 24-U calcium, following 24-U creatinine, 24-U Urea, 24-U sodium, serum creatinine, and weight.Conclusion: Except for serum calcium, all other predictors had direct and/or indirect effects on 24-U calcium. Serum 25(OH)D had a negligible indirect effect on 24-U calcium. Controlling dietary intake of protein and sodium and bodyweight seems very important in kidney stone formers with hypercalciuria.
Demonstrating The Importance of Cultural Considerations At End-Of-Life Utilising The Perspective of Indian Patients With Cancer
Authors: Chittem Mahati , Eliott Jaklin , Olver Ian 
Published: September 2021

Abstract
Purpose

To contrast with an Australian study, this study aimed to understand Indian cancer patients’ hopes and beliefs about the end-of-life, particularly focusing on how this informed their preferences regarding end-of-life treatment. In India, individuals’ lives are mainly guided by culturally driven practices of doing right by one’s family and believing death is predetermined.
Methods

Indian patients (25) diagnosed with advanced incurable cancer and aware of their prognosis participated in semi-structured interviews exploring their hopes as they approached the end-of-life. The interview also sought to understand patients’ views and beliefs about DNR orders and euthanasia. The interviews were transcribed and analysed using Interpretative Phenomenological Analysis.
Results

Two major themes were identified: (i) a desire for living or dying comprising sub-themes of perceptions of current responsibilities, and, having a fighting spirit versus feelings of despair, and (ii) God was the ultimate decision-maker of life and death. Further, patients understood that a do-not-resuscitate order meant euthanasia and responded accordingly. Some patients reported hoping for death due to the pain and resultant suffering. However, patients did not talk about euthanasia openly, instead choosing to describe it within a larger framework of life and death.
Conclusions

Indian patients reaching the end-of-life valued their family responsibilities which determined their desire to live or die. However, all patients believed that God decided on their life and death. It is important to consider cultural perspectives on DNR or euthanasia, and to address patients’ pain management needs towards the end-of-life.
The Impact of the COVID-19 Outbreak on Intensive Care in Northern Saitama Japan
Authors: Nakamura Ken , Orii Kouan , Kondo Taichi , Nakao Mitsutaka , Wakatabe Makoto 
Published: September 2021

Abstract
Background

We examined and compared the actual impact of COVID-19 on local medical care in northern Saitama Japan, especially in intensive care units (ICUs), before (2019) and during (2020) the pandemic.
Methods

The impact of COVID-19 on emergency care responses was compared with acceptances and refusals in 2019 and 2020. We also examined the number of surgeries performed by ICU surgical departments. The impact on intensive care was examined regarding the numbers of incident reports and the severity percentage calculated from the integrated team medical care and safety system. We also compared the overtime work of physicians working.
Results

In 2019, there were 2,136 emergency patient requests, and 1,811 patients were received. In contrast, in 2020, there were 2,371 emergency patient requests, and 1,822 patients were accepted, representing a decrease of 76% (p = 0‧931). There were significantly more refusals in 2020, 303 (14‧1%) in 2019 and 506 (21‧3%) in 2020 (p = 0‧0004). In 2020, the number of surgeries increased in neurosurgery, cardiac surgeries, and vascular surgeries and over time increased in all surgical units. There were 396 incidents reported in ICUs in 2019; this increased significantly to 510 in 2020 (p = 0‧001).
Conclusion

Even though intensive care management was restricted, the number of patients and doctors’ overtime work increased compared to before the spread of COVID-19, and the surrounding environment led to an increase in the number of incidents. The environments in ICUs must be actively improved to prepare for an even more severe situation in the future.
Airway Management Difficulties in a Helicopter Emergency Medical Service (HEMS): A Retrospective Observational Study of 676 Out-of-Hospital Intubations
Authors: Pietsch Urs , Müllner Raphael , Theiler Lorenz , Wenzel Volker , Meuli Lorenz , Knapp Jürgen , Sollid Stephen J.M. , Albrecht Roland 
Published: September 2021

Abstract
Background: Airway management is a key skill in any helicopter emergency medical service (HEMS). Successful intubation is less often than in the hospital, and alternative forms of airway management are needed more often. Methods: Retrospective observational cohort study in an anaesthesiologist-staffed HEMS in Switzerland. Patients charts from all scene calls (n=9035) that took place between June 2016 and May 2017 (12 months) were analysed. The primary outcome parameter was intubation success rate. Secondary parameters included number of patients intubated by ground-based emergency medical services, alternative devices used, and comparison of patients with and without difficulties in airway management. Results: A total of 676 patients with invasive ventilatory support were identified. Difficulties in airway management were rare, occurring in 44 (6.5%) patients, and trauma was significantly more common (59.1% vs. 38.6%, p<0.001). In 335 (49.6%) patients, advanced airway management had already been initiated by Ground emergency medical services upon arrival of the HEMS. Paramedics had significantly more exposure to patients needing prehospital anaesthesia than the HEMS physicians; median 12 (IQR 9 to 17.5) versus 3 (IQR 2 to 6), p<0.001.Conclusion: Despite overall high success rates for endotracheal intubation in the physician-staffed service, each physician gets little real-life experience with advanced airway management in the field, highlighting the importance of a solid basic competence such as anaesthesiology and additional training. Direct laryngoscopy is still a valuable skill and an important Plan B in difficult airway situations in which factors such as fogging, blood, bright radiation on the video laryngoscopes screen, impaired the success of video laryngoscopes intubation.
Analysis of Patients Undergoing Prostate Biopsy Procedure In Outpatient Care
Authors: Shimabukuro Patrícia Mitsue Saruhashi , Guerra Carla Morales , DE MORAIS RICHARLISSON BORGES , Taminato Monica 
Published: September 2021

Abstract
Currently in the concept of de-hospitalization and consequently an increase in invasive procedures performed in the extra-hospital environment. This work aims to identify the signs and symptoms of an adverse event related to prostate biopsy. This is a cohort and retrospective research through the registration of patient care in electronic medical records after the exam. In the period from 2016 to 2018, 3,570 exams were performed, with 491 patients presenting the criteria for the classification of infection related to the procedure that strictly obeys the criteria established by the Centers Diseases Control (CDC). The inclusion criteria for patients were those who, within 15 days after performing the prostate biopsy, had emergency care due to the presence of signs and symptoms. The exams analyzed were urine culture and blood culture collected at the time of emergency care. The results were that of the 491 patients evaluated, 38 (9%) patients required hospitalization, the average age of the hospitalized patients was 71.5 years and all had at least one associated comorbidity on positive cultures, 13 for E. coli with total sensitivity to aminoglycosides and carbapenems and partial sensitivity to fluoroquinolones, 1 Protein spp sensitive to aminoglycosides and carbapenems and 1 Salmonella spp sensitive to fluoroquinolones and carbapenems. Thus, it is noted the importance of the infection control nurse's activity in the diagnostic medicine units for the elaboration of protocols adapted to the outpatient reality.
Liver Fibrosis is Associated with a Decrease in Gait Speed in Older Men with Chronic Liver Disease: A Retrospective Cross-Sectional Study
Authors: Fudeyasu Kenichi , Nomura Takuo , Kawae Toshihiro , Iwaki Daisuke , Nakashima Yuki , Nagao Akiko , Hiramatsu Akira , Aikata Hiroshi , Chayama Kazuaki , Kimura Hiroaki 
Published: September 2021

Abstract
Background: Although it has already been reported that chronic liver disease (CLD) can induce sarcopenia, the impact of sarcopenia, especially on motor function, in older patients with CLD is still unclear. Therefore, we investigated the effects of liver fibrosis on motor function in these patients.Methods: In all, 117 older patients with CLD aged above 60 years (men, n=70; women, n=47) were included in this study. We examined the presence or absence of sarcopenia and checked motor functions such as muscle strength and walking speed. The results were compared between patients with FIB-4 index of >3.25, indicative of severe-degree liver fibrosis (SLF), and those with an index of <3.25, indicative of low-degree liver fibrosis (LLF). We also analyzed the factors related to the decrease in gait speed.Results: The decrease in gait speed (<1.0 m/s) was significantly higher (P = 0.027) and the knee extension force (KEF) was significantly lower (P = 0.010) in men with SLF than in those with LLF. In this study, liver fibrosis (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.56–0.90) and KEF (OR = 1.09, 95% CI = 1.02–1.16) were identified as factors associated with the decrease in gait speed.Conclusions: Older male patients with CLD have decreased motor function as the disease progresses. We found that the decrease in gait speed is related to liver fibrosis and KEF. It is necessary to focus on the motor function of older patients with CLD, especially the gait speed.
Identification of Hub Gene and Potential Drugs for Enzalutamide Resistant Castration-Resistant Prostate Cancer Depend On Bioinformatics Analysis
Authors: Chen Xi , Wu Yechen , Wang Xinan , Xu Chengdang , Wang Licheng , Yao Yicong , Wu Denglong , Wu Gang 
Published: September 2021

Abstract
BackgroundAndrogen deprivation therapy (ADT) is still the first line method to treat PCa. However, after a period of therapy, primary PCa will inevitably progress into castration-resistant prostate cancer (CRPC). Enzalutamide (MDV3100) is an androgen receptor (AR) signal inhibitor which can delay the progression of CRPC and increase survival of patients with metastatic CRPC. However, the mechanisms of enzalutamide resistant castration-resistant prostate cancer (EnzR CRPC) are still controversial. MethodsWe collected RNA-seq data of enzalutamide resistant castration-resistant prostate cancer cell line LNCaP (EnzR LNCaP) from GSE44905, GSE78201 and GSE150807. We found hub gene from the three datasets. Then we tested the expression of hub gene in TCGA database and potential drug that has effect on hub gene. Finally, we verified the hub gene expression and drug function.ResultsFrom GSE44905, GSE78201 and GSE150807, we found 45 differently expressed genes (DEGs) between LNCaP and EnzR LNCaP. Ten hub gene were found in protein-protein interaction (PPI) network. The hub gene expression and survival analysis were analyzed by GEPIA depend on TCGA database. We found that CDK6 was highly expressed in both EnzR LNCaP cell and prostate cancer patients. Ten potential small molecules can suppress CDK6 expression from CMap. Finally, we verified the expression of CDK6 in both CRPC patients’ samples and prostate cancer cell lines. The function of three potential CDK6 inhibitors, apigenin, chrysin and fisetin, was tested in prostate cancer cell lines.ConclusionsThe study proved that the mutation of CDK6 maybe a reason to the occurrence of CRPC and suppress CDK6 expression may be a potential way in treating CRPC.