bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Nail Avulsion as a Treatment for Nail Diseases: A Retrospective Case Series
Authors: Tay Vanessa Hwee Ting , Leung An Jian , Pan Jiun Yit 
Published: December 2024

Abstract

Background:
Chemical nail avulsion is a non-invasive therapeutic option for nail diseases. It is an alternative to long-term antifungals or painful surgical procedures. This study evaluates its efficacy and safety in treating various nail diseases.

Materials and Methods:
A retrospective analysis was conducted on chemical nail avulsions performed on 157 patients at the National Skin Centre, Singapore, from January 2013 to December 2015. Nail avulsion was performed by paring the nail and applying 40% urea ointment followed by an occlusive dressing.

Results:
There were 157 patients in this retrospective study. Gender was equally distributed. Patient ages ranged from 40 to 78 years (mean age: 49.8 years). Most patients had avulsions performed on toenails (n = 118, 75.2%). The most common indication for nail avulsion was onychomycosis (n = 80, 51.0%). At 1 week post-occlusion, 33.8% (n = 53) of nails were fully avulsed (defined as clearance of 100% of the nail) and 57.3% (n = 90) were partially avulsed (defined as clearance of more than 50% of the nail). At 6 months post-treatment, 26.0% (n = 26 of 100) of nails were clinically cured (defined as the normal appearance of 100% of the regrown nail) and 42.0% (n = 42 of 100) had clinical improvement (defined as normal appearance of more than 50% of the regrown nail). At 12 months post-treatment, 24.3% (n = 17 of 70) of nails remained clinically cured and 34.3% (n = 24 of 70) remained clinically improved. Most patients (n = 130, 82.8%) did not experience any side effects. A minority had pain, irritant contact dermatitis, bleeding or cellulitis.

Conclusion:
Chemical nail avulsion with 40% urea ointment under occlusion is a moderately effective and safe treatment method for various nail diseases. More than 50% nail avulsion was achieved in most patients (n = 143, 91.1%) after 1 week, 58.6% (n = 41 out of 70) had more than 50% of normal regrown nail at 12 months and the majority (n = 130, 82.8%) did not experience any side effects.
Comparison of Low Dermatitis Potential of a Powder-free “Accelerator-free” Synthetic Neoprene with Natural Rubber Latex Glove Using Modified Draize Test
Authors: Zainuri Noramini , Ismail Sharifah , Sulaiman Saadiah , Jeffrey Iman , Jeffrey Asiah Farihah , Al Ghora Said , Jeffrey Mardhiah 
Published: December 2024

Abstract

Introduction:
Glove-related dermatitis and latex sensitivity are becoming more prevalent as the health care industry’s need for protective rubber gloves increases. Neoprene gloves have emerged as a safer alternative to traditional natural rubber latex (NRL) gloves for surgical and examination purposes, in reducing the risk of Type I allergy and Type IV allergy.

Aims:
The study objective is to compare the dermatitis potential of powder-free neoprene gloves with that of NRL gloves by determining whether there is presence or absence of residual chemical additives at the level that may induce Type IV allergy in unsensitised general users.

Materials and Methods:
Two sets of accelerator free sterile powder-free synthetic neoprene (SN) surgical gloves, (GAMMEX®)*, green and natural colour were tested using the Modified Draize-95 test. Filter paper and Powder-Free NRL glove were used as control.

Results:
A total of 211 subjects completed the study; 160 of them were Caucasian (76%), 30 were Afro-Caribbean (14%) and 21 were Asian (10%). Both sets of neoprene gloves, green and natural colour, and their control, powder-free NRL examination glove and the filter paper had final patch testing score of not more than 1.5 during the challenge phases.

Conclusions:
The skin sensitisation test of sterile powder-free SN surgical gloves, green and natural colour and the powder-Free NRL examination gloves were negative indicating no clinical evidence of the presence of residual chemical additives at the level that may induce Type IV allergy in the unsensitised general user population. Both types of gloves qualify as ‘Low Dermatitis Potential’.
Use of Biological Drugs in Patients with Chronic Dermatoses at Hospital Umum Sarawak: A 13-year Real-world Data
Authors: Teo Hock Gin , Lai Siaw Ling , Ting Ingrid Pao Lin , Teo Yan , Albela Henrietta , Tang Min Moon 
Published: December 2024

Abstract

Introduction:
There has been a paradigm shift in the treatment of various chronic dermatoses using biological drugs. We aim to describe the characteristics of patients with chronic dermatoses who receive biological drugs.

Materials and Methods:
This was a retrospective study on the patients who received any form of biological drugs at the dermatology clinic between 2010 and July 2023. Medical records were retrieved and analyzed.

Results:
A total of 78 patients received biological drugs for 13 years. The median age of the patients who first received the biological drugs was 39.6 years (range: 3–82). The biological drugs funding resources were from the hospital medication fund (45.2%), public servant fund (36.6%), and others. Psoriasis was the most common indication with a total of 62 (79.5%) patients, followed by atopic dermatitis (n = 8, 10.3%), and chronic spontaneous urticaria (n = 4, 5.1%). In our subanalysis of the use of biological drugs for 62 patients with psoriasis, the most frequently used agents were the interleukin 17 (IL-17) inhibitor secukinumab (39.0%) and anti-IL12/23 ustekinumab (26.0%). There were 33 (42.3%) patients who achieved meaningful with sustainable clinical response and were continued with the biological drugs longer than 12 months (range: 14–114 months). Thirteen patients switched to another biological drug mainly due to loss of efficacy. Twelve patients stopped completely mainly due to primary failure and adverse events. The most severe adverse events reported were tuberculosis and hepatitis B reactivation.

Conclusion:
About 42.3% of patients had sustainable responses with the first biological drugs prescribed for more than a year.
Psychiatric Comorbidities in Adults with Epilepsy: A Systematic Review
Authors: Murugan Arun , S Geethanjali , Jeevapriya M. R. , Pavithra G. , OL Athira , Sathishkumar K. 
Published: December 2024

Abstract
Epilepsy is a chronic neurological condition that is highly predisposed to a variety of mental health problems. This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based on clinical assessments amongst patients with epilepsy (PWE). The included articles were published from 2000 to 2022 and focused on adults aged ≥18 years who had psychiatric diagnoses. The primary outcome was the prevalence of psychiatric comorbidities amongst PWE. A modified Newcastle–Ottawa Scale was used to assess the quality of the studies. Thirty-three articles were reviewed in full-text screening. Out of these, 15 articles that were consistent with the inclusion criteria were included in our systematic review. This protocol was registered in PROSPERO with registration ID CRD42023461739. General Anxiety Disorder and Major Depressive Disorder were the most common psychiatric comorbidities, with prevalence rates of 20.14% and 23.94%, respectively. Other reported comorbidities included post-traumatic stress disorder (8.3%), obsessive–compulsive disorder (2.9%), bipolar disorder (7.1%), psychosis (8.2%) and phobia (18.25%). These findings suggest that screening tools for depression and anxiety should be included as part of the training for epilepsy care.
Efficacy of Online Learning in Children during COVID-19 Pandemic: A Systematic Review and Meta-analysis
Authors: Panda Prateek Kumar , Sharawat Indar Kumar , Panda Pragnya 
Published: December 2024

Abstract

Background Objective:
During the current ongoing COVID-19 pandemic, schools have been closed in most of countries to prevent the spread of infection. Most schools have adapted online learning in a desperate attempt to continue the teaching–learning process. There was no systematic review on the published literature on the effectiveness of this online learning process.

Materials and Methods:
Major electronic databases were searched to retrieve the original articles (cross-sectional or prospective studies), and studies with a minimum sample size of 40 were included in the analysis. The pooled estimate of the percentage of parents/teachers having various perceptions was calculated using fixed and random effect designs, depending on the degree of heterogeneity.

Results:
Ten studies described 21,144 students/teachers/parents fulfilling the eligibility criteria from a total of 178 records. Overall, 82% of children included in the study were found to have attended online learning classes. Of these, only 38% of parents, 41% of students, and 51% of teachers felt that online learning was effective in achieving its goal properly. As high as 91% of parents and 83% of students reported that they would like to go back to traditional classroom teaching after the pandemic was over. While around 90% of teachers felt that they were able to interact regularly with the students, 57% of parents felt that there was not enough interaction during online classes, and only 42% of children seemed to be interested in the online class.

Conclusion:
While online learning classes seem to be the only feasible alternative during the COVID-19 pandemic, their effectiveness in fulfilling the goal of education in children is far from perfect, as perceived by parents, students, and teachers.
Home Handling, Storage, and Disposal of Oral Methotrexate in Rheumatoid Arthritis Patients at King Abdulaziz University Hospital: A Cross-Sectional Study
Authors: Bakhsh Hussain T. 
Published: December 2024

Abstract

Introduction:
Many patients on oral methotrexate (MTX) may not practice safe home handling, storage, and disposal methods, possibly due to a lack of information from healthcare providers.

Objectives:
We aimed to evaluate the safe home handling, storage, and disposal practices of oral MTX among patients treated for rheumatoid arthritis.

Materials and Methods:
A cross-sectional, telephone interview and questionnaire-based survey was conducted on rheumatoid arthritis patients at the Rheumatology Department of King Abdulaziz University Hospital. The patients were eligible for inclusion if they were at least 18 years old and received oral MTX treatment between January and November 2021. The data were summarized using descriptive statistics. Chi-squared and correlation analyses were employed to test for differences in proportions and associations.

Results:
A total of 114 patients, with a mean age of 46.5 ± 13.2 years and 96 females (84.2%; P < 0.001), participated in the study. Not splitting or crushing the MTX medication was the major safe home handling method reported by 68 (59.6%; P < 0.001) of the patients. Safe disposal was the most practiced by patients, with a median (range) total score of 3.0 (1.0–4.0). There was no significant correlation between the patients’ level of education and their total safe handling (r = −0.154, P = 0.101), storage (r = −0.023, P = 0.809), and disposal practice (r = −0.004, P = 0.966) scores.

Conclusion:
There was poor safe home handling of oral MTX by the patients. Poor home handling of oral MTX by patients is a health risk, requiring healthcare providers, particularly pharmacists, to educate patients and caregivers about safe disposal and storage practices.
Progression, behavior, and intervention of dentigerous cyst: A case report and literature review
Authors: Ali MK Saad , Alfaleh Haya Mohammed , Alnasser Imtenan Nasser 
Published: December 2024

Abstract
A dentigerous cyst is a developmental odontogenic cyst frequently associated with lower third molars, upper canines, and lower second premolars. In most cases, dentigerous cysts are present asymptomatically. The growth is gradual and when it reaches a significant size, it may affect anatomical structures and adjacent teeth. The majority of these cysts are detected during regular radiographic examination. They are induced by the degeneration of the enamel organ’s stellate reticulum, which results in fluid accumulation between the crown and the reduced enamel epithelium. In the presented case, we report the progression of a dentigerous cyst associated with an impacted left mandibular third molar. The cyst behavior, differential diagnosis, and management are discussed.
A decision support system based on classification algorithms for the diagnosis of periodontal disease
Authors: Alshehri Abdulrahman , Dahman Mohammed , Assiri Mousa , Alshehri Abdulkarim , Alqahtani Sharifah , Shaiban Mohammed , Alqahtani Bashyer , Althbyani Sabah , Alhefdi Hatem , Hakami Khalid , Ali Abdulbari , Saeed Abdullah 
Published: December 2024

Abstract

Introduction:
Inflammatory conditions, including gingivitis and periodontitis, affect the supporting structures of teeth. The early detection of these diseases is critical for the prevention of systemic complications. Recent advances in artificial intelligence have introduced novel diagnostic methods that offer the potential for more accurate and personalized diagnostics.

Aims:
The purpose of this study was to develop and evaluate a decision support system (DSS) based on selected classification algorithms, namely random forest (RF), support vector machine (SVM), artificial neural network (ANN), and logistic regression for the periodontal disease diagnosis.

Materials and Methods:
A cross-sectional study design was adopted, A 300 patients were taken, split into a training set with 80% and a test set with 20%. The algorithms were used to analyze 19 demographic, clinical, and radiographic parameters. Chi-square and ANOVA tests were conducted and for these, a significance level of 0.05 was used. We calculated accuracy, precision, recall and F1-score, which we used to assess model performance.

Results:
The RF and ANN models exhibited very good performance, reaching almost perfect accuracy, precision, recall and F1 scores, showing strong potential as a diagnostic. Nevertheless, the SVM and decision tree models equally yielded robust results with a balanced generalizability across metrics. Results showed little effectiveness for the Naïve Bayes on grading periodontal disease.

Discussion and Conclusion:
DSS models show promise in enhancing periodontal disease diagnostics, particularly RF and ANN models. However, the risk of overfitting and limited performance of simpler models, such as naive Bayes, underscores the need for further research, including external validation, to ensure the reliability and generalizability of these models in clinical practice.
THE IMPACT OF LEADERSHIP STYLES ON EMPLOYEE JOB SATISFACTION AND TURNOVER INTENTIONS IN CORPORATE SECTOR
Authors: Zafar Ammad 
Published: December 2024

This study investigates the relationship between employee job satisfaction, work environment, and intention to leave a company. It delves into the impact of two leadership styles, transformational and participative, aiming to address employee satisfaction and retention issues. Data was collected from 300 individuals using a quantitative research approach. The findings of the study reveal a strong connection between transformational and participative leadership styles, job satisfaction, and the inclination to leave one's current job. Statistical analysis, specifically chi-square tests, demonstrates significant associations between leadership with transformational qualities, employee job satisfaction, and the desire to leave the organization. Participative leadership approaches also correlate highly with job satisfaction and intentions to leave. Binary logistic regression analysis further supports the role of leadership styles in influencing turnover intentions. The research establishes a significant relationship between leadership styles and job satisfaction, as well as leadership styles and employee turnover intentions. Moreover, it underscores that a one-time shift in leadership style can result in a 15-fold change in job satisfaction and a 7-fold change in employee turnover intentions.
A Thyroid Carcinoma Induced by COVID-19 and its Effect on The Variation of Thyroglobulin Level as a Marker for Diagnosis and Assessment Strategy
Authors: Kudhair Ahmed Hassan , Almahbobi Taghreed F. , Jawad Anfal Abdulhussain , Baqer Enas Jalil , Kadhim Dhuha Abdullah , Al-Mayaly Adel Sahib , Abbas Hanan Diekan 
Published: December 2024

Background: the thyroid carcinoma is one of the most cases seen of the thyroid un expected disease. Due to its increase in the no of cases reported there is un urgent interest of the prognostic risk expectations and the out come of the treatment. there will be an increment of the cases and an interesting in prohibit its complications by follow-up this disease. Aim: is to predict the effect of the thymoglobulin test in facilitating its diagnosis in consideration with selectivity and the specify. Results: data indicated that although this test is helpful in the diagnosis but still it is not only deoendable test used due to lack of complete accuracy in different cases of the thyroid disease. one of the main reasons for the thyroid carcinoma is viral infection, particularly COVID due its effect on the endocrine function of the human body especially thyroid gland and its abnormally proliferation and behavior that could be ends with tumors even if this tumor is multifactorial but there is and evedance that it caused by viral infection.
Gestión Integral de Residuos de la Administración Pública- Provincia de Buenos Aires. El Programa G.I.R.A analizado desde el ciclo de las Políticas Públicas (2020 a 2024)
Authors: Portugheis Alexander , Wahlberg Federico 
Published: December 2024

El presente artículo tiene como objetivo realizar una evaluación preliminar de la Gestión de Residuos de la Administración Pública de la Provincia de Buenos Aires, desde los propios agentes que han investigado las dimensiones de la problemática, y han aportado en su normativización e implementación. El enfoque teórico escogido es el ciclo de las políticas públicas de Subirats (2008) y Jaime (2013), donde se ponderan distintas fases, desde su germinación en la inclusión en la agenda gubernamental, en la formulación de una resolución específica a esa temática, a sus estrategias de implementación cotidiana y por último a la fase de evaluación, la cual se expone como resultado preliminar del presente artículo. La técnica metodológica aplicada para la elaboración e instrumentalización de la política mencionada en todas sus dimensiones, es la investigación acción participativa (IAP), con la cual se pudo construir, bajo la demanda con los propios organismos ministeriales, las más efectivas estrategias de segregación en origen de residuos, para que estos sean expresados en la resolución 331/23 y en su posterior implementación.
Abstract
This article aims to provide a preliminary assessment of the Waste Management practices within the Public Administration of Buenos Aires Province, from the perspective of the agents who have studied the issue and contributed to its regulation and implementation. The chosen theoretical approach is the public policy cycle by Subirats (2008) and Jaime (2013), where different phases are weighted, from its germination in the inclusion in the governmental agenda, in the formulation of a specific resolution to that theme, to its daily implementation strategies and finally to the evaluation phase, which is exposed as a preliminary result of this article. The theoretical framework used is the public policy cycle proposed by Subirats (2008) and Jaime (2013), which emphasizes various stages: from the initial inclusion of the issue on the government agenda to the formulation of a specific resolution, followed by strategies for daily implementation, and finally, to the evaluation phase, which is presented as the preliminary result of this article. The methodological approach employed for the development and implementation of the policy in all its dimensions is participatory action research (PAR), which allowed for the creation, in collaboration with the relevant ministerial agencies, of the most effective waste segregation strategies at the source, as reflected in Resolution 331/23 and its subsequent implementation.
Algorithmic Experience of Brand Management on Social Media Platforms
Authors: Jessi Hema , Chandran M. 
Published: December 2024

Objectives: The study aims to explore the constructs of algorithmic experience in brand management within the social media domain. It seeks to identify and validate the factors influencing consumer perception and their relationship with brand management on popular social media platforms.

Methods: A survey-based approach was adopted, and 500 responses were collected using the convenience sampling method. The research analyzed the interplay between brands, social media platforms, and societal culture, focusing on how algorithms shape consumer experiences and brand management strategies.

Results: The findings reveal that brands successfully create a significant impulsive impact on consumers, enabling them to manage their brand presence despite market competition. A notable relationship exists between brands and societal culture, where brands leverage cultural elements to connect with consumers. However, the study indicates that social media platforms do not significantly influence the existing cultural framework of consumer society.

Conclusion: The research concludes that algorithmic brand management in the social media domain plays a crucial role in shaping consumer perception. By effectively utilizing societal culture and social media infrastructure, brands can enhance their presence and consumer engagement without altering the core cultural dynamics of the consumer society.
Immersive Virtual Reality Assisted Physical Activities: Efficacy on Physical, Health Parameters and Parental Perspectives for Mobility-Impaired Middle Childhood
Authors: G. Nirmaladevi , Prabha R. Saravana 
Published: December 2024

Objectives: This study aims to evaluate the efficacy of Immersive Virtual Reality-Assisted Physical Activities (IVR-APA) on physical and health parameters in children with Mobility Impairments during Middle Childhood (MIMC). It also seeks to examine parental perspectives on the feasibility, accessibility, and perceived benefits of IVR-APA.

Methods: A total of 24 children with MIMC from Coimbatore District, India, were selected using disproportional stratified sampling and randomly assigned to two groups: the IVR-APA Interventional Group (n = 12) and a Non-Interventional Group (CG: n = 12). Participants were matched by age (9–12 years). Physical and health indicators such as coordination, strength, heart rate, and flexibility were assessed before and after the intervention. The impact of IVR-APA was analyzed using ANCOVA with effect size. Qualitative data were also collected from parents regarding their perspectives on the intervention.

Results: The findings demonstrated a significant positive impact of IVR-APA on physical and health parameters in the intervention group compared to the non-interventional group. Parents expressed favorable views on the feasibility and accessibility of IVR-assisted activities, emphasizing its benefits in improving physical health and providing enjoyable recreational experiences for children with mobility impairments.

Conclusion: The study concludes that IVR-APA is an effective approach to enhancing physical activity and health in children with mobility impairments during middle childhood. Its immersive and engaging nature offers substantial benefits, including improved coordination, strength, and flexibility, as well as positive parental feedback regarding its practical application and accessibility.