bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiotoxicity of antiangiogenic drugs: causes and mechanisms
Authors: Tomaszewska Beata , Muzolf Małgorzata , Grabysa Radosław , Bodnar Lubomir 
Published: June 2021

Therapy with angiogenesis inhibitors is undoubtedly an advancement in cancer treatment; however, it is associated with a risk of developing cardiotoxicity, which most often manifests in myocardial contractile dysfunction or an increased risk of thromboembolic events. Heart failure is observed in 2–4% of patients treated with bevacizumab and in 3–8% of patients on antiangiogenic tyrosine kinase inhibitors.
The proposed pathomechanisms underlying the impairment in systolic function during antiangiogenic drug treatment include mitochondrial dysfunction, a secondary reduction in cardiomyocyte ATP production and redox imbalance, which may contribute to pathological states known as “free radical diseases”. Additionally, therapy with angiogenesis inhibitors may also cause cardiac oxidative stress.
The risk factors for cardiac complications include arterial hypertension, which is a known “class effect” of this class of drugs, as well as a number of other factors such as age, comorbidities, prior radiotherapy and baseline left ventricular ejection fraction.
The cardiovascular diseases are still the first cause of death in the world. The more effective oncological treatment becomes, the more often comorbidities occur. This fact seems to demand interdisciplinary approach from investigators and practitioners.
This article presents the current state of knowledge on the molecular mechanisms of cardiotoxicity of antiangiogenic drugs used in routine clinical practice.
Small animal general practice veterinarians' use and perceptions of synchronous video-based telemedicine in North America during the COVID-19 pandemic
Authors: Bishop Greg T. , Rishniw Mark , Kogan Lori R. 
Published: June 2021

Abstract

OBJECTIVE
To assess small animal general practice veterinarians' use and perceptions of synchronous video-based telemedicine before and during the coronavirus disease 2019 (COVID-19) pandemic.

SAMPLE
550 respondent veterinarian members of the Veterinary Information Network (VIN).

PROCEDURES
An anonymous online survey was used to gather data from VIN-member veterinarians in small animal general practice regarding their perceptions and use of synchronous video-based telemedicine. Two emails to all VIN members were used to distribute the web-based questionnaire. For consistency, only responses from North American veterinarians who reported working in small animal general practice were included in analyses. Responses were collected between September 28, 2020, and October 21, 2020.

RESULTS
There were 69,488 recipients and 680 respondents (1.0% response rate), 550 of whom had North American internet protocol addresses and reported working in small animal general practice. Not all respondents answered all questions. Use of video-based telemedicine substantially increased among respondents during the COVID-19 pandemic, and most (86/130 [66.2%]) reported little to no difficulty in adopting videoconferencing. Respondents also reported that telemedicine took less time (61/135 [45.2%]) and resulted in less financial compensation (103/135 [76.3%]) than in-person consultation. Several respondents reported concerns regarding legal issues and potential inferiorities of telemedicine.

CONCLUSIONS AND CLINICAL RELEVANCE
Our results indicated that a substantial proportion of respondents incorporated synchronous video-based telemedicine into their practices during the COVID-19 pandemic. Despite low perceived difficulty in adopting videoconferencing telemedicine, many planned to discontinue it for some clinical applications once the pandemic is over. Further research is required to elucidate the perceptions and challenges in successful use of veterinary telemedicine.
Concept of Biohydrogen Production by Agricultural Enterprises
Authors: Kukharets Savelii , Hutsol Taras , Glowacki Szymon , Sukmaniuk Olena , Rozkosz Anna , Tkach Oleg 
Published: June 2021

Abstract
Biohydrogen production in agricultural enterprises is an urgent matter. It is appropriate to utilize two methods of biohydrogen production: a thermochemical method – from crop-based biomass and anaerobic digestion (fermentation) method – from animal-based biomass.. It is appropriate to use gasifiers for the thermochemical method and biore-actors for fermentation method.
The theoretical potential of biohydrogen was established with due regard to the amount of biomass which is necessary for utilization in livestock agriculture, for fields fertilization as well as with the consideration of the coefficients of concordance with hydrogen equivalent and loss factor under biohydrogen production. The theoretical potential of biohydrogen from crop-based biomass in Ukraine amounts to 77 billion m3, during the period of three years (on average 25.6 billion m3 per year).
The Analysis of Opinions About Teaching Profession on Twitter Through Text Mining
Authors: Gündüzalp Seda , Şener Gönül 
Published: June 2021

Abstract
Billions of data in social media have provided a very influential platform for researchers to make research on data analysis. In the digital age, it has become essential for conducting an analysis of written things in social media in which the individuals express easily themselves without any pressure and for studying big data. It has been known that there are shared subjects on the education like almost every subject on the Twitter platform. Accordingly, it is often shared about many issues relating to education. The purpose of the present study is to analyze shared ideas on the ‘teaching’ profession through this program, which has become popular recently. It was observed that the shared tweets were often related to the current problems about education and Twitter was used as a platform by the individuals to explain their problems. It was a considerable finding that most of the tweets focused on contracted teaching, the positions of appointment, public personnel selection exam and the system of exams, issues about assignation, paid to teach and interview issues that there are a great number of reaction tweets against negative evaluation about vacations of teacher and particularly, against the situations just like damaging the sanctity the teaching profession and these tweets take place in the category the most retweeted. With this research, it is suggested to make analyses on social media platforms with other data mining techniques on the same subject or different subjects, to analyze the shares of institutions and to examine the sharing of the Ministry of National Education
Influence of B16/F10 melanoma growth variant on the level of cytochrome C in mitochondria in various organs of female mice
Authors: Frantsiyants E. M. , Neskubina I. V. , Cheryarina N. D. , Surikova E. I. , Nemashkalova L. A. 
Published: June 2021

Introduction. Cytochrome C in mitochondria transfers electrons from complex III to complex IV, and it is a signaling molecule in the apoptosis realization.The objective was to evaluate the level of cytochrome C in cell mitochondria in various organs of female mice with standard and stimulated growth of experimental B16/F10 melanoma.Methods and materials. The experiment was performed on female C57BL/6 mice (n=168). The groups were: intact animals (n=21); controls with a model of chronic neurogenic pain (CNP) (n = 21); group M — standard B16/F10 melanoma transplantation (n=63), group CNP + M — B16/F10 melanoma transplantation 3 weeks after CNP model creation (n=63). The level of cytochrome C (ng / mg protein) were measured by ELISA (Bioscience, Austria). Statistical analysis of results was performed using the «Statistica 10.0» program.Results. After 1 week of standard melanoma growth, an increase in the level of cytochrome C by 2.7 and 1.7 times was detected in mitochondria of the brain and liver; by the 3rd week, it decreased in the liver and skin by 1.7 times. In melanoma mitochondria, the level of cytochrome C was lower than in the skin of intact animals: by 2.5 times after week 1, by 4.5 times after week 2, and by 4.6 times after week 3. After 1 week of stimulated melanoma growth, the level of cytochrome C decreased compared control values: by 2.2 times in the brain, by 1.9 times in the liver, by 1.4 times in the skin; by week 3, it decreased by 4.8 times in mitochondria of the brain, by 4.7 times — in the liver, by 2.3 times — in the heart, by 1.9 times — in the skin. In melanoma mitochondria, the level of cytochrome C was lower than in the skin of intact animals: by 15.3 times after week 1, by 10.3 times after week 2, and by 8.8 times after week 3.Conclusion. Low level of cytochrome C were found in melanoma mitochondria in standard and stimulated tumor growth. The data can be used in the experiment and in clinic for using exogenous cytochrome C as an agent slowing down the malignant process.
Application of categories of the International classification of functioning in the organization of medical rehabilitation of patients who have suffered a new coronavirus infection COVID-19
Authors: Afanasyeva V. V. , Potapchuk A. A. , Chernysh N. V. 
Published: June 2021

The objective was to determine the most significant categories of ICF that allow us to provide objective information about the biopsychosocial state of patients who have suffered a new coronavirus infection COVID-19 and to choose the most effective methods of rehabilitation based on the rehabilitation diagnosis of each group of patients.Methods and materials. On the basis of the clinic of the Pavlov University, a course of medical rehabilitation was conducted for 2 weeks for patients who had suffered a new coronavirus infection in severe and moderate degree of course. 2 groups were formed: EG1-25 people participating in the rehabilitation program with the use of physical exercises and EG2 — 39 people with the use of physical exercises and physiotherapy. A categorical rehabilitation profile of patients by ICF domains was compiled.Results. As a result of the application of the medical rehabilitation program, a statistically significant improvement in the indicators in EG 2 was revealed. The respiratory function (the Barbell test) improved by 14.6%, the functional state of the cardiovascular system according to the DBP indicator by 3.9%. The analysis of the results of the ICF category «activity and participation» revealed a statistically significant improvement in the motor test parameters (6MSHT) in both groups: by 11.9 % in EG2 and by 20.6 % in EG1.Conclusions. The results of the study indicate the positive impact of the proposed program of medical rehabilitation and confirm the relevance of the problem, unsolved problems and prospects for scientific research on this topic.
Epileptic Spasms-West syndrome secondary to Dravet syndrome due to SCN gene mutation from India
Authors: Gowda Vykuntaraju K. , Vegda Hemadri , Amoghimath Raghavendraswami , Battina Manojna , Shivappa Sanjay K. , Benakappa Naveen 
Published: June 2021

Objectives:
West syndrome (WS) is a triad of epileptic spasms, developmental delay/regression, and hypsarrhythmia. SCN related epileptic encephalopathy is a rare epilepsy syndrome characterized by an early-onset, severe, and epileptic encephalopathy. The causes of WS are multiple and diverse ranging from genetic to structural, metabolic, and unknown causes. The objectives of the study were to report SCN related epileptic encephalopathies with epileptic spasms.

Materials and Methods:
This is retrospective chart review of children presenting with epileptic spasms secondary to SCN gene variants from January 2015 to March 2020 in a tertiary care referral center.

Results:
Out of 15 children, ten were boys. The mean age of presentation was 5 months. Thirteen children had preceded seizures before epileptic spasms in the 1st year of life, two children presented initially with epileptic spasms. No neuro-deficits were noted in all the children. In all the cases electroencephalogram was suggestive of hypsarrhythmia. Routine testing, neuroimaging, and metabolic tests were normal in all the cases. Various pathogenic variants seen in next-generation sequencing were SCN1A in 11, SCN1B and SCN2A in two children each. Three children responded for vigabatrin and five children responded for steroids but all of them had relapse and were refractory to other antiepileptic drugs.

Conclusion:
SCN related epileptic encephalopathy should be considered in the differential diagnosis of epileptic spasms. These infants present earlier compare to classical Dravet syndrome children.
Development of mind mapping-based comics to improve math learning outcomes
Authors: Trimurtini Trimurtini , Setyani Mira Amalia , Sari Elok Fariha , Nugraheni Nursiwi 
Published: June 2021

<div><p>This study aims to develop, study the feasibility and effectiveness of mathematics comic media based on <em>mind mapping</em> for fifth-grade students of public elementary schools in Demak. The method used is the Sugiyono Research and Development model consisting of 7 steps. The data analysis technique used descriptive statistics, t-test, z-test and n-gain. The results showed the development process of mathematical comic media based on mind mapping on speed and discharge topics with the local cultural background of Demak city. Media was assessed by material, media, and language experts, and It showed valid results and very feasible to be implemented. This media's effectiveness is indicated by the improvement of the Students’ learning outcomes and learning achievement. Students and teachers' response about this media shows positive responses because the comic media are practical and complete content, such as (material, question, assignment, solution, and evaluation). The conclusion is learning media has been successfully developed. Mathematics comic media based on mind mapping is very feasible and practical used in learning mathematics, and it is efeffectively improvements’ learning.</p></div>
Hebrew Incunabula in the Russian Researchers’ Publications. Bibliographic Review
Authors: Iakerson Semen M. 
Published: June 2021

Hebrew incunabula amount to a rather modest, in terms of number, group of around 150 editions that were printed within the period from the late 60s of the 15th century to January 1, 1501 in Italy, Spain, Portugal and Turkey. Despite such a small number of Hebrew incunabula, the role they played in the history of the formation of European printing cannot be overlooked. Even less possible is to overestimate the importance of Hebrew incunabula for understanding Jewish spiritual life as it evolved in Europe during the Renaissance.Russian depositories house 43 editions of Hebrew incunabula, in 113 copies and fragments. The latter are distributed as following: the Institute of Oriental Manuscripts of the Russian Academy of Sciences — 67 items stored; the Russian State Library — 38 items; the National Library of Russia — 7 items; the Jewish Religious Community of Saint Petersburg — 1 item. The majority of these books came in public depositories at the late 19th — first half of the 20th century from private collections of St. Petersburg collectors: Moses Friedland (1826—1899), Daniel Chwolson (1819—1911) and David Günzburg (1857—1910). This article looks into the circumstances of how exactly these incunabula were acquired by the depositories. For the first time there are analysed publications of Russian scholars that either include descriptions of Hebrew incunabula (inventories, catalogues, lists) or related to various aspects of Hebrew incunabula studies. The article presents the first annotated bibliography of all domestic publications that are in any way connected with Hebrew incunabula, covering the period from 1893 (the first publication) to the present. In private collections, there was paid special attention to the formation of incunabula collections. It was expressed in the allocation of incunabula as a separate group of books in printed catalogues and the publication of research works on incunabula studies, which belonged to the pen of collectors themselves and haven’t lost their scientific relevance today.
The Birth of Bibliologos. To the 100th Anniversary of the Institute of Book Studies
Authors: Sokolov Arkadiy V. 
Published: June 2021

M.N. Kolesnikova’s monograph “Ahead of Time. To the 100th Anniversary of the Institute of Book Studies (Petrograd-Leningrad, 1920—1933)”, published in 2020, is a valuable contribution to the history of book science, library science, bibliography science, the general history of Russian culture and a fascinating textbook for students of library, information and media cultural school. The history of the Institute of Book Studies is a vivid illustration of the relationship between the totalitarian power and the creative intelligentsia. The monograph, which contains detailed biographical information about the employees of the Institute of Book Studies, can be called a reference book of library science and book science elite of Leningrad in the 1920s. All the classic problems of bibliography science, library science and book science were in the field of view of the staff of the Institute of Book Studies. Considering the constructive program of activities and the strong team of enthusiasts, the Institute could have grown into a truly research institution if the overall development of the country had gone differently.Based on the analysis of the scientific-research and educational activities of the Institute, it is concluded that it can be considered the birthplace of the Russian Bibliologos. Bibliologos is interpreted in two ways: first, as a social group of intellectuals-book lovers who ensure the functioning of the national bibliosphere; second, as a universe of bibliological knowledge embodied in book form as a result of scientific, pedagogical and practical activities of intellectuals-book lovers. The author highlights that it is necessary to preserve the memory of the Leningrad Institute of Book Studies, which served as the “cradle of the Russian Bibliologos” in the history of book culture.
Professional Information Needs of Library Specialists in Russia
Authors: Neshcheret Marina Y. 
Published: June 2021

The article is devoted to the comprehensive study of the professional information needs (IN) of specialists of the central libraries of the subjects of the Russian Federation. The rapid development of high technologies in the field of accumulation, transmission and processing of information, the creation of modern telecommunications systems have led to the emergence of fundamentally new opportunities for organizing the information process. This, in turn, led to the qualitative growth of IN specialists, including those employed in the field of library activities. The specific features of IN library specialists are determined by their place and role in the modern process of cultural activity, industry orientation, nature of work and specialization. During 2018—2019, the Centre for Research of Problems of the Development of Libraries in the Information Society of the Russian State Library carried out research aimed at comprehensive study of the information needs of cultural workers employed in the library sphere. At the first stage of the research, there was comprehended the existing experience of studying professional information needs in the national library science. At the second stage, using the method of questionnaire survey, information needs of library specialists were studied in order to identify the most rational forms and methods of providing them. The analysis of the survey results made it possible to identify the sources of professional information, to reveal information resources that have the greatest importance and characterize specific features of librarians’ information needs.The author concludes on the need to expand the access to full-text databases and electronic versions of periodicals for library staff. The creation of integrated information centre could help providing library professionals with professional information. Currently, the function of such a centre is performed by the National Electronic Library, which includes the professional section for library specialists. The results of the study form theoretical and methodological basis for the rational use of resources and potential of libraries in providing information to professional information needs of library specialists and determine the prospects for further research related to improving the forms and methods of information service for this category of users.
LEY DE INTERRUPCIÓN VOLUNTARIA DEL EMBARAZO (IVE) ARGENTINA 2020, EVIDENCIA DE LA AUTONOMÍA DEL EMBRIÓN.
Authors: Chirinos Ríos Carlos Alberto 
Published: June 2021

El siguiente artículo identificó los principales argumentos sobre los que se estructura la aprobación de la ley de interrupción voluntaria del embarazo (IVE) en argentina el 30 de diciembre del 2020, inicialmente se analizó la autonomía del embrión, su manejo aceptado en las técnicas de reproducción asistida, el derecho a la protección a través del tiempo de la vida humana y los “daños a terceros”.
Analizamos datos del ministerio de salud respecto a los casos de muerte materna asociados al aborto clandestino, así mismo se hizo referencia a la normativa de la UNESCO en su declaración sobre bioética y los derechos humanos, sustentados en argumentos de Kant sobre la verdad y la autonomía del ser humano, con el sustento teórico fisiológico se realizó una descripción general de las etapas siguientes a la fecundación comprobando así, la evidencia de autonomía del embrión y su capacidad de mantenerse viable en situaciones adversas incluso en ambientes extra materno tal como lo realizan las técnicas de reproducción asistida.
Se concluyó con la propuesta de proteger la vida por encima de todo interés, teniendo en cuenta que en ciertas circunstancias especiales en nuestro país no existe una norma oficial clara que la proteja además se requiere mayor legislación al respeto, porque en la ley promulgada en Argentina se vulnera la autonomía del embrión humano.