bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart Team/Guidelines Discordance Is Associated With Increased Mortality: Data From a National Survey of Revascularization in Patients With Complex Coronary Artery Disease
Authors: Witberg Guy , Segev Amit , Barac Yaron D. , Raanani Ehud , Assali Abid , Finkelstein Ariel , Roguin Ariel , Sahar Gideon , Vaknin-Assa Hana , Bolotin Gil , Eitan Amnon , Klempfner Robert , Goldenberg Ilan , Kornowski Ran 
Published: January 2021

Background:
Practice guidelines emphasize the role of the SYNTAX score (SS; Synergy Between PCI With TAXUS and Cardiac Surgery) in choosing between percutaneous coronary intervention and coronary artery bypass graft surgery in cases of complex coronary artery disease. There is paucity of data on the implementation of these recommendations in daily practice, and on the consequences of guideline discordant revascularization.

Methods:
This was a retrospective analysis of a prospective national survey of consecutive real world patients undergoing coronary revascularization for complex coronary artery disease according to decisions of local heart team at each center. SS was calculated at a dedicated CoreLab, and patients were classified as heart team/guidelines agreement/discordant.

Results:

Nine hundred seventy-nine patients (571 percutaneous coronary intervention and 408 coronary artery bypass graft) were included. Mean age was 65 years and the mean SS was 22. Heart team/guidelines discordance occurred in 170 (17.3%) patients. Independent predictors of heart team/guidelines discordance were age, admission to a center with no cardiac surgery service, SS, and previous percutaneous coronary intervention/myocardial infarction. A multivariate model based on these characteristics had a C statistic of 0.83. Thirty-day outcomes were similar in the agreement/discordance groups, however, heart team/guidelines discordance was associated with a significant increase in 3 year mortality (17.6% versus 8.4%; hazard ratio, 2.05;
P
=0.002) after multivariate adjustment.

Conclusions:
Heart team/guidelines discordance is not infrequent in real world patients with complex coronary artery disease undergoing revascularization. This is more likely to occur in elderly patients, those with more complex coronary disease (as determined by the SS), and those treated at centers with no cardiac surgery service. These patients have a higher risk for mid-term mortality.
Randomized Trial of Aspirin Versus Warfarin After Transcatheter Aortic Valve Replacement in Low-Risk Patients
Authors: Rogers Toby , Shults Christian , Torguson Rebecca , Shea Corey , Parikh Puja , Bilfinger Thomas , Cocke Thomas , Brizzio Mariano E. , Levitt Robert , Hahn Chiwon , Hanna Nicholas , Comas George , Mahoney Paul , Newton Joseph , Buchbinder Maurice , Moreno Ricardo , Zhang Cheng , Craig Paige , Asch Federico M. , Weissman Gaby , Garcia-Garcia Hector M. , Ben-Dor Itsik , Satler Lowell F. , Waksman Ron 
Published: January 2021

Background:
The optimal antithrombotic regimen after transcatheter aortic valve replacement remains unclear.

Methods:

In this randomized open-label study, low-risk patients undergoing transfemoral transcatheter aortic valve replacement at 7 centers in the United States were randomized 1:1 to low-dose aspirin or warfarin plus low-dose aspirin for 30 days. Patients who could not be randomized were enrolled in a separate registry. Computed tomography or transesophageal echocardiography was performed at 30 days. The primary effectiveness end point was a composite of the following at 30 days: hypoattenuated leaflet thickening, at least moderately reduced leaflet motion, hemodynamic dysfunction (mean aortic valve gradient ≥20 mm Hg, effective orifice area ≤1.0 cm
2
, dimensionless valve index <0.35, or moderate or severe aortic regurgitation), stroke, or transient ischemic attack.

Results:

Between July 2018 and October 2019, 94 patients were randomly assigned, 50 to aspirin and 44 to warfarin plus aspirin, and 30 were enrolled into the registry. In the intention-to-treat analysis of the randomized cohort, the composite primary effectiveness end point was met in 26.5% for aspirin versus 7.0% for warfarin plus aspirin (
P
=0.014; odds ratio, 4.8 [95% CI, 1.3–18.3]). The rate of hypoattenuated leaflet thickening was 16.3% for aspirin versus 4.7% for warfarin plus aspirin (
P
=0.07; odds ratio, 4.0 [95% CI, 0.8–20.0]). There was no excess bleeding at 30 days with anticoagulation. In the as-treated analysis of pooled randomized and registry cohorts, the rate of hypoattenuated leaflet thickening was 16.7% for aspirin versus 3.1% for warfarin plus aspirin (
P
=0.011; odds ratio, 6.3 [95% CI, 1.3–30.6]).

Conclusions:
In low-risk transcatheter aortic valve replacement patients, anticoagulation with warfarin may prevent transcatheter heart valve dysfunction in the short term without excess bleeding.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT03557242.
CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing
Authors: Cortese Jonathan , Rasser Charlotte , Even Guillaume , Bardet Sylvia M. , Choqueux Christine , Mesnier Jules , Perrin Marie-Laure , Janot Kevin , Caroff Jildaz , Nicoletti Antonino , Michel Jean-Baptiste , Spelle Laurent , Caligiuri Giuseppina , Rouchaud Aymeric 
Published: January 2021

Background and Purpose:
Beyond aneurysmal occlusion, metallic flow diverters (FDs) can induce an adverse endovascular reaction due to the foreignness of metal devices, hampering FD endothelialization across the aneurysm neck, and arterial healing of intracranial aneurysms. Here, we evaluated the potential benefits of an FD coating mimicking CD31, a coreceptor critically involved in endothelial function and endovascular homeostasis, on the endothelialization of FDs implanted in vivo.

Methods:
Nitinol FD (Silk Vista Baby) and flat disks were dip-coated with a CD31-mimetic peptide via an intermediate layer of polydopamine. Disks were used to assess the reaction of endothelial cells and blood elements in vitro. An aneurysm rabbit model was used to compare in vivo effects on the arterial wall of CD31-mimetic–coated (CD31-mimetic, n=6), polydopamine-coated (polydopamine, n=6), and uncoated FDs (bare, n=5) at 4 weeks post-FD implantation. In addition, long-term safety was assessed at 12 weeks.

Results:
In vitro, CD31-mimetic coated disks displayed reduced adhesion of blood elements while favoring endothelial cell attachment and confluence, compared to bare and polydopamine disks. Strikingly, in vivo, the neoarterial wall formed over the CD31-mimetic-FD struts at the aneurysm neck was characteristic of an arterial tunica media, with continuous differentiated endothelium covering a significantly thicker layer of collagen and smooth muscle cells as compared to the controls. The rates of angiographic complete occlusion and covered branch arterial patency were similar in all 3 groups.

Conclusions:
CD31-mimetic coating favors the colonization of metallic endovascular devices with endothelial cells displaying a physiological phenotype while preventing the adhesion of platelets and leukocytes. These biological properties lead to a rapid and improved endothelialization of the neoarterial wall at the aneurysm neck. CD31-mimetic coating could therefore represent a valuable strategy for FD biocompatibility improvement and aneurysm healing.
Defining a Target Population to Effectively Test a Neuroprotective Drug
Authors: Olivé-Gadea Marta , Requena Manuel , Campos Daniel , Garcia-Tornel Alvaro , Deck Matías , Muchada Marian , Boned Sandra , Rodríguez Noelia , Juega Jesús , Rodríguez-Luna David , Pagola Jorge , Rubiera Marta , Hernández-Jiménez Macarena , Molina Carlos A. , Ribo Marc 
Published: January 2021

Background and Purpose:
We aim to identify the subgroup of acute ischemic stroke patients with higher probabilities of benefiting from a potential neuroprotective drug using baseline outcome predictors and test whether different selection criteria strategies can improve detected treatment effect.

Methods:
We analyzed the association between final infarct volume (FIV), measured on 24- to 72-hour computed tomography, and National Institutes of Health Stroke Scale at discharge/day 5 of acute stroke patients who underwent endovascular treatment. Models were adjusted for age, sex, and affected hemisphere. We analyzed the impact of absolute (5–15 mL) and relative (33%) FIV reductions in the National Institutes of Health Stroke Scale in the whole population and in different subsets of patients selected according to baseline imaging criteria using computed tomography perfusion.

Results:

We analyzed 627 patients; association between FIV and 5-day National Institutes of Health Stroke Scale was best described with a quadratic function, with a regression coefficient β=1.56 ([95% CI, 1.45–1.67]
P
<0.001) in the adjusted analysis. In the models considering a fixed absolute (5/15 mL) FIV reduction, treatment effect was highest when patients with predicted larger FIV were excluded, whereas in a 33% FIV reduction model, treatment effect increased with the exclusion of patients with expected excellent outcomes.

Conclusions:
Patients either with excellent outcomes after endovascular thrombectomy or with large infarcts may dilute the treatment effect in stroke neuroprotective drug trials. Computed tomography perfusion on admission may help selecting adequate patients according to expected drug effect profile.
Hybridity and Transformation: The Political Orientation of the Chinese in the Dutch East Indies
Authors: Lin Dong-Yu , Lin Ping 
Published: January 2021

Abstract
During the early twentieth century, strong nationalistic ideas sprang up in Indonesia. Some Chinese elites in professional positions under the Dutch colonial government tended to side with the Dutch with the pro-Dutch attitude; some working for Chinese newspapers or agencies developed the pro-China stance; some supported and cooperated with the indigenous people with the pro-independence tendency; and others had their inclinations transformed over the course of time. After examining the life history of a few prominent Chinese figures, this article shows that three levels of factors—international politics in East Asia, local politics in the Dutch East Indies, and their life histories under Dutch rule (together with travel experience to China)—were critical for each Chinese person in establishing or transforming their often hybrid political orientations. The Chinese preference was neither monolithic nor settled, so the general assumption that “Chinese people are loyal to China” in Indonesian politics of the colonial era should be revised.
Intensity Change of Binary Tropical Cyclones (TCs) in Idealized Numerical Simulations: Two Initially Identical Mature TCs
Authors: Liu Hao-Yan , Wang Yuqing , Gu Jian-Feng 
Published: January 2021

AbstractThis study investigates the intensity change of binary tropical cyclones (TCs) in idealized cloud-resolving simulations. Four simulations of binary interaction between two initially identical mature TCs of about 70 m s−1 with initial separation distance varying from 480 to 840 km are conducted in a quiescent f-plane environment. Results show that two identical TCs finally merge if their initial separation distance is within 600 km. The binary TCs presents two weakening stages (stages 1 and 3) with a quasi-steady evolution (stage 2) in between. Such intensity change of one TC is correlated with the upper-layer vertical wind shear (VWS) associated with the upper-level anticyclone (ULA) of the other TC. The potential temperature budget shows that eddy radial advection of potential temperature induced by large upper-layer VWS contributes to the weakening of the upper-level warm core and thereby the weakening of binary TCs in stage 1. In stage 2, the upper-layer VWS first weakens and then restrengthens with relatively weak magnitude, leading to a quasi-steady intensity evolution. In stage 3, due to the increasing upper-layer VWS, the nonmerging binary TCs weaken again until their separation distance exceeds the local Rossby radius of deformation of the ULA (about 1600 km), which can serve as a dynamical critical distance within which direct interaction can occur between two TCs. In the merging cases, the binary TCs weaken prior to merging because highly asymmetric structure develops as a result of strong horizontal deformation of the inner core. However, the merged system intensifies shortly after merging.
Impacts of Large-Scale Soil Moisture Anomalies on the Hydroclimate of Southeastern South America
Authors: Bieri Carolina A. , Dominguez Francina , Lawrence David M. 
Published: January 2021

AbstractThe La Plata basin (LPB), located in southeastern South America (SESA), is a region of significant socioeconomic importance, particularly for agriculture. This area of South America exhibits strong land–atmosphere coupling in the warm season. In this work, we evaluate the impact of large-scale soil moisture (SM) anomalies on regional-scale atmospheric conditions. Multivariate empirical orthogonal function (EOF) analysis is used to extract the dominant modes of joint variability of monthly averaged root-zone SM and 1-month-lagged precipitation from atmospheric reanalyses. We find that the dominant EOF pattern is consistent with a positive correlation between antecedent SM and precipitation, while the second dominant EOF pattern is consistent with a negative correlation between these variables. To evaluate causality, the effects of large-scale SM anomalies on atmospheric variables are examined using the Community Earth System Model (CESM). CESM simulations suggest that anomalously dry SM is initially collocated with decreased precipitation. Subsequent changes in the atmospheric circulation associated with a thermal low draw moisture into the region, eventually promoting increased precipitation. This study investigates the pathways through which SM anomalies modulate precipitation in this region. For this reason, this study has potential atmospheric prediction applications that could benefit the population and the socioeconomic well-being of this important region.
An 8-yr Meteotsunami Climatology across Northwest Europe: 2010–17
Authors: Williams David A. , Schultz David M. , Horsburgh Kevin J. , Hughes Chris W. 
Published: January 2021

AbstractMeteotsunamis are shallow-water waves that, despite often being small (~0.3 m), can cause damage, injuries, and fatalities due to relatively strong currents (>1 m s−1). Previous case studies, modeling, and localized climatologies have indicated that dangerous meteotsunamis can occur across northwest Europe. Using 71 tide gauges across northwest Europe between 2010 and 2017, a regional climatology was made to understand the typical sizes, times, and atmospheric systems that generate meteotsunamis. A total of 349 meteotsunamis (54.0 meteotsunamis per year) were identified with 0.27–0.40-m median wave heights. The largest waves (~1 m high) were measured in France and the Republic of Ireland. Most meteotsunamis were identified in winter (43%–59%), and the fewest identified meteotsunamis occurred in either spring or summer (0%–15%). There was a weak diurnal signal, with most meteotsunami identifications between 1200 and 1859 UTC (30%) and the fewest between 0000 and 0659 UTC (23%). Radar-derived precipitation was used to identify and classify the morphologies of mesoscale precipitating weather systems occurring within 6 h of each meteotsunami. Most mesoscale atmospheric systems were quasi-linear systems (46%) or open-cellular convection (33%), with some nonlinear clusters (17%) and a few isolated cells (4%). These systems occurred under westerly geostrophic flow, with Proudman resonance possible in 43 out of 45 selected meteotsunamis. Because most meteotsunamis occur on cold winter days, with precipitation, and in large tides, wintertime meteotsunamis may be missed by eyewitnesses, helping to explain why previous observationally based case studies of meteotsunamis are documented predominantly in summer.
Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors
Authors: Shanmugam Vignesh , Craig Jeffrey W. , Hilton Laura K. , Nguyen Matthew H. , Rushton Christopher K. , Fahimdanesh Kian , Lovitch Scott , Ferland Ben , Scott David W. , Aster Jon C. 
Published: January 2021

Abstract
Notch receptors participate in a signaling pathway in which ligand-induced proteolysis frees the Notch intracellular domain (NICD), allowing it to translocate to the nucleus, form a transcription complex, and induce target gene expression. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), splenic marginal zone B-cell lymphoma (SMZL), and distinct subsets of diffuse large B-cell lymphoma (DLBCL) are strongly associated with mutations in the 3′ end of NOTCH1 or NOTCH2 that disrupt a proline, glutamic acid, serine, and threonine (PEST) degron domain and stabilize NICD1 and NICD2. By contrast, mutations leading to constitutive Notch activation are rare in primary B-cell neoplasms, suggesting that Notch activation is confined to ligand-rich tumor microenvironments, or that cryptic strong gain-of-function mutations have been missed in prior analyses. To test these ideas, we used immunohistochemical stains to screen a broad range of B-cell tumors for Notch activation. Our analyses reveal that among small B-cell neoplasms, NICD2 is primarily detected in SMZL and is a common feature of both NOTCH2 wild-type and NOTCH2-mutated SMZLs, similar to prior findings with NOTCH1 in CLL/SLL. The greatest NOTCH2 activation was observed in NOTCH2-mutated SMZLs, particularly within splenic marginal zones. By contrast, little evidence of NOTCH2 activation was observed in DLBCL, even in NOTCH2-mutated tumors, suggesting that selective pressure for NOTCH2 activation is mainly confined to low-grade B-cell neoplasms, whereas DLBCLs with NOTCH1 mutations frequently showed evidence of ongoing NOTCH1 activation. These observations have important implications for the pathogenic role of Notch and its therapeutic targeting in B-cell lymphomas.
Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT
Authors: Wang Yiwen , Zhou Weiyin , Wang Junke , Karaesmen Ezgi , Tang Hancong , McCarthy Philip L. , Pasquini Marcelo C. , Wang Youjin , McReynolds Lisa J. , Katki Hormuzd A. , Machiela Mitchell J. , Yeager Meredith , Pooler Loreall , Sheng Xin , Haiman Christopher A. , Van Den Berg David , Spellman Stephen R. , Wang Tao , Kuxhausen Michelle , Chanock Stephen J. , Lee Stephanie J. , Clay-Gilmour Alyssa I. , Hahn Theresa E. , Gadalla Shahinaz M. , Sucheston-Campbell Lara E. 
Published: January 2021

Key Points
Pre-HCT mosaicism is related to increased relapse risk and lower survival after unrelated HCT, independent of cytogenetics at diagnosis. Pre-HCT mosaicism could be a useful clinical tool to guide risk stratification in acute lymphoblastic leukemia patients.
scReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets
Authors: Liu Hongyu , Prashant N. M. , Spurr Liam F. , Bousounis Pavlos , Alomran Nawaf , Ibeawuchi Helen , Sein Justin , Słowiński Piotr , Tsaneva-Atanasova Krasimira , Horvath Anelia 
Published: January 2021

AbstractBackgroundRecently, pioneering expression quantitative trait loci (eQTL) studies on single cell RNA sequencing (scRNA-seq) data have revealed new and cell-specific regulatory single nucleotide variants (SNVs). Here, we present an alternative QTL-related approach applicable to transcribed SNV loci from scRNA-seq data: scReQTL. ScReQTL uses Variant Allele Fraction (VAFRNA) at expressed biallelic loci, and corelates it to gene expression from the corresponding cell.ResultsOur approach employs the advantage that, when estimated from multiple cells, VAFRNAcan be used to assess effects of SNVs in a single sample or individual. In this setting scReQTL operates in the context of identical genotypes, where it is likely to capture RNA-mediated genetic interactions with cell-specific and transient effects. Applying scReQTL on scRNA-seq data generated on the 10 × Genomics Chromium platform using 26,640 mesenchymal cells derived from adipose tissue obtained from three healthy female donors, we identified 1272 unique scReQTLs. ScReQTLs common between individuals or cell types were consistent in terms of the directionality of the relationship and the effect size. Comparative assessment with eQTLs from bulk sequencing data showed that scReQTL analysis identifies a distinct set of SNV-gene correlations, that are substantially enriched in known gene-gene interactions and significant genome-wide association studies (GWAS) loci.ConclusionScReQTL is relevant to the rapidly growing source of scRNA-seq data and can be applied to outline SNVs potentially contributing to cell type-specific and/or dynamic genetic interactions from an individual scRNA-seq dataset.Availability:https://github.com/HorvathLab/NGS/tree/master/scReQTL
Effects of the scope of practice on family physicians: a systematic review
Authors: Zomahoun Hervé Tchala Vignon , Samson Isabelle , Sawadogo Jasmine , Massougbodji José , Gogovor Amédé , Diendéré Ella , Turgeon Frédéric , Légaré France 
Published: January 2021

Abstract
Background
Family medicine is a branch of medicine that manages common and long-term illnesses in children and adults. Family physicians in particular play a major role and their scope of practice is expected to impact patient and population. However, little is known about its impact on physicians. We aimed to assess the effects of scope of practice on family physician outcomes.

Methods
We performed a systematic review that we reported using PRISMA guidelines. For the inclusion criteria, any study exploring an association between the scope of practice and physician outcomes was considered. Three bibliographic databases Medline, Embase, and ERIC were consulted through OVID interface from their respective inceptions to November, 2020. Two reviewers independently selected studies, extracted data and assessed the risk of bias of studies using appropriate tools. We conducted data synthesis using a narrative form. GRADE was used for evaluating quality of cumulative evidence.

Results
In total, we included 12 studies with 38,732 participants from 6927 citations identified. Eleven of them were cross-sectional, and one was a cohort study with acceptable methodological quality. We found that: 1) family physicians with diverse clinical and nonclinical activities significantly improve their job satisfaction (p<0.05); 2) family physicians with a variety of clinical practices significantly improve their competences and health status (p<0.05); 3) family physicians who perform clinical procedures (mainly extended to gynecological procedures) significantly improve their psychosocial outcomes (e.g., job satisfaction) (p<0.05); and 4) some associations are not statistically significant (e.g., relation between variety of practice settings and outcomes). We observed that the evidence available has a very low level.

Conclusions
Our findings suggest that the scope of practice may be favorably associated with some family physician outcomes but with a very low level of evidence available. Based on these findings, healthcare system managers could monitor the scope of practice among family physicians and encourage future research in this field.

Systematic review registration
Our protocol was registered under the number CRD42019121990 in PROSPERO.