bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of eHealth to promote physical activity in thoracic malignancies survivors: a systematic review and meta-analysis.
Authors: Rodríguez-Torres Janet , Calvache-Mateo Andrés , Ortíz-Rubio Araceli , Muñoz-Vigueras Natalia , López-López Laura , Martin-Núñez Javier , Valenza Marie Carmen 
Published: May 2021

Abstract
PurposeSurvival rates for many forms of thoracic malignancies have improved over the past few decades, however, many survivors are coping with the side effects of cancer treatment for longer. Physical activity has been proposed as a therapeutic strategy to act across multiple organ systems and improve clinical outcomes and eHealth could be a good way to encourage patients. The aim of this systematic review was to explore the effects of eHealth in the promotion of PA among thoracic malignancies.MethodsSuitable articles were searched using PubMed, Web of Science and Scopus databases using a combination of medical subject headings. Articles were screened by two independent reviewers and were included if they presented an eHealth intervention to improve PA in thoracic malignancies.ResultsIn total, 4781 articles were identified, of which ten met eligibility criteria. Different eHealth interventions were described in these studies: mobile application (app) (n=3), website (n=2), email (n=2), web and mobile application (n=1), telephone counseling (n=1) and online sheet (n=1). All studies reported improvements in PA, with 8/10 studies reporting statistically significant changes. ConclusionMeta-analysis revealed eHealth is a good way to improve PA in thoracic malignancies survivors, compared to no intervention, conventional treatment or a diet approach. Future studies are needed to clarify the specific intervention to improve these patients’ recovery.
Enhanced Sensitivity of Non-Small-Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox Balance
Authors: Kim Suntae , Im Ji Hye , Kim Wan Kyu , Choi Young Jae , Lee Ji-Yoon , Kim Sang Kyum , Kim Sun Jo , Kwon Sung Won , Kang Keon Wook 
Published: May 2021

Abstract
Background Although the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR- TKI) therapy has been proven in non-small cell lung cancer (NSCLC) patients, acquired resistance to EGFR-TKIs presents a serious clinical problem. Hence, the identification of new therapeutic strategy is needed to treat EGFR-TKI-resistant NSCLC. MethodsAcquired EGFR-TKI resistant lung cancer cell lines (HCC827, H1993 and H292 cells with acquired resistance to gefitinib or erlotinib) were used for cell-based studies. IncuCyte live cell analysis system and XFp analyzer were used for the determination of cell proliferation and energy metabolism, respectively. In vivo anti-cancer effect of phenformin was assessed in xenografts implanting HCC827 and gefitinib-resistant HCC827 (HCC827 GR) cells. ResultsHCC827 GR and erlotinib-resistant H1993 (H1993 ER) cells exhibited different metabolic properties compared with their respective parental cells, HCC827 and H1993. In EGFR-TKI-resistant NSCLC cells, glycolysis markers including the glucose consumption rate, intracellular lactate level, and extracellular acidification rate were decreased; however, mitochondrial oxidative phosphorylation (OXPHOS) markers including mitochondria-driven ATP production, mitochondrial membrane potential, and maximal OXPHOS capacity were increased. Cell proliferation and tumor growth were strongly inhibited by biguanide phenformin via targeting of mitochondrial OXPHOS complex 1 in EGFR-TKI-resistant NSCLC cells. Inhibition of OXPHOS resulted in a reduced NAD+/NADH ratio and intracellular aspartate levels. Recovery of glycolysis by hexokinase 2 overexpression in erlotinib-resistant H292 (H292 ER) cells significantly reduced the anti-cancer effects of phenformin.Conclusion Long-term treatment with EGFR-TKIs causes reactivation of mitochondrial metabolism, resulting in vulnerability to OXPHOS inhibitor such as phenformin. We propose a new therapeutic option for NSCLC with acquired EGFR-TKI resistance that focuses on cancer metabolism.
About Magnets and Superconductors of Mr Scanners
Authors: Vujović Željko Đ. 
Published: May 2021

Abstract
The topic of this paper are parts of modern MR devices, in which the magnet windings are located. MR scanner magnets are made of four types of electromagnetic windings: 1) The main magnet, made of superconducting material, creates a variable magnetic field; 2) X coil, made of a resistive material, creates a variable magnetic field, horizontally, from left to right, across scanning tube; 3) Y coil creates varaing magnetic field, vertically, from botom to top; 4) Z coil creates varaing magnetic field, longitudinally, from head to toe, within scanning tube.Superconductors, which create the main magnetic field, should be cooled by liquid helium and liquid nitrogen. Main magnets made of superconductors should use cryostat, with cooling vessels with liquid helium and liquid nitrogen, thermal insulation and other protective elements of magnet system. The types of magnets that exist in the basic configurations of MR scanners are analyzed. Scanners in the form of a closed cylindrical cavity create their own, magnetic, fields by passing current through the solenoid, which is held at the temperature of the superconductor. The superconductors used exclusively are: niobium-titanium (NbTi), niobium-tin (Nb3Sn), vanadium-gallium (V3Ga) and magnesium-diboride (MgB2). Only magnesium diboride is a high temperature superconductor, with a critical temperature Tc = 390K. The three remaining superconductors are low temperature. New high-temperature superconductors have been discovered, as well as room-temperature superconductors. Newly discovered superconducting materials are not used in MR scanners. The magnet structure of the MR scanner is complex. The resonant frequency changes at each point of the field in a controlled manner. The windings of the main magnet made of superconducting material in the form of microsial fibers are built into the copper core. The nonlinear gradient field is created by windings of conductive material. It is added to the main magnetic field. Thus, the resulting magnetic field is obtained.
Giant Ovarian Cysts Treated by Single-Port Laparoscopic Surgery: A Case Series
Authors: Jiang Lili , Liu Kuiran 
Published: May 2021

Abstract
Background:
Ovarian cysts are very common diseases of female reproductive system. Giant ovarian cysts refer to the tumors with diameters greater than 10 cm. In recent years, due to the development of clinical diagnosis, imaging modalities and the improvement of patients' cognition of the diseases, the occurrence of giant ovarian cysts become rare. The purpose of this study was to show a new operation method of single-port laparoscopy to treat giant ovarian cysts.
Methods:
We report a case series of 5 patients with giant ovarian cysts who underwent single-port laparoscopic surgery in gynecology department, Shengjing Hospital of China Medical University between June 2020 and March 2021. The inclusion criteria were ovarian cysts at least 20 cm in diameters, and cases which the tumor might be malignant were excluded.
Results:
The patients' mean age was 26.2years. The most common clinical presentation was progressive abdominal distension. Median size of the cysts at imaging was 39.2 cm (range 21–63 cm). All patients underwent single-port laparoscopic surgery, and none of them converted to laparotomy. On final pathological reports, two cysts were serous cystadenomas, and three were mucinous cystadenomas. All patients recovered well and discharged on time.
Conclusion:
Giant ovarian cysts can be treated by single-port laparoscopic surgery. In addition to the well-known advantages of laparoscopic surgery (e.g., small pelvic interference, fast postoperative recovery), it can also play the role of perfect cosmetic results, which has more advantages for young women.
The effect of using instrumental music on the pain and anxiety levels of patients with impacted third molar surgery
Authors: Moadabi Amirhossein , Kazemi Mahsa , Moosazadeh Mahmood , Zamanzadeh Maryam , Ghasemi Shohreh , Akbari Sara 
Published: May 2021

Abstract
Background :Anxiety and fear about dentistry are a global problem that affects a large number of people around the world. Music, as a soothing method, can be used as a relaxing treatment to relieve anxiety and discomfort pain of the patient.Purpose: This analysis aimed to check the instrumental music therapy effect on anxiety and pain levels in patients undergoing surgical treatment of an impacted third molar.Materials and Methods: In this investigation, 88 patients who were contender for third molar extraction were isolated into the mediation and control groups. In the mediation bunch, delicate instrumental music was played from the time the patients went into the working room until the finish of the medical procedure when the patient left the room. Patients' pain and nervousness levels were estimated by the Visual Analog Scale (VAS).Results: The consequences of this investigation showed that there were no measurably critical difference in depression, pain, preoperative anxiety, and postoperative uneasiness in the control and intervention group (P>0.05); however, preoperative anxiety was basically more noteworthy than postoperative anxiety in the two group (p=0.001).Conclusion: As per the outcomes, it sems to be that utilizing music doesn't lead to measurably significant difference in the nervousness level in patients going through third molar medical procedure. However, it is suggested that different analysts direct further examinations with larger sample sizes just as choosing the music dependent on the people's preferences.
The Relationship of Individual, Occupational and Psychological Factors With Low Back Pain Among Steel Industry Workers
Authors: Ahmadi Fatemeh , Esmaily Habibollah , Pakdaman Seyedeh Paria , Rafeemanesh Ehsan 
Published: May 2021

Abstract
Objectives: Low back pain (LBP) is one of the most common and most costly work-related musculoskeletal disorders. There are numerous factors that may affect the development of this disease. The aim of this study was to determine the prevalence of low back pain (LBP) and its association with individual, occupational and psychosocial factors among steel industry workers.Methods: For this cross-sectional study, 273 workers in a steel plant were selected by random sampling method. The participants were divided into production (n=168) and administrative (n=105) Workers. Data was collected through in-person interview, physical examination, modified Nordic questionnaire and Osipow questionnaire. Data was analyzed by descriptive statistical methods, chi-square test, t-student،test and logistic regression model using SPSS-20 software. In all statistical analysis P value≤ 0.05 was considered as statistically significant.Results: Despite the young age of participants (39.63±6.32 years) and their short employment duration, the prevalence of LBP was high (38.5%) in this industry. Gender, body mass index, smoking status and total stress score were similar in two groups. No significant relationship was found between LBP and current job status. However, LBP prevalence was significantly associated with age and duration of employment (P<0.05).Conclusion: In our study no association was observed between LBP and the participants' current job status and work- related stress. It appears that life style modifications along with education can decrease the rate of low back pain and its risk factors in employees of this industry.
COVID 19 disease independently predicted endothelial dysfunction measured by flow-mediated dilatation
Authors: Ergül Elif , YILMAZ AHMET Seyda , Öğütveren Muhammed Mürsel , Emlek Nadir , Kostakoğlu Uğur , Çetin Mustafa 
Published: May 2021

Abstract
Background: The systemic effects of COVID-19 disease are still largely uncertain and needs to be scrutinized with further trials. Endothelial dysfunction (ED) is responsible of the majority of adverse cardiovascular events. Flow-mediated dilation (FMD) is easily obtainable method to assess ED accurately. It is aimed to evaluate ED by measuring FMD following COVID-19 disease.Methods: Patients diagnosed with COVID-19 disease were recruited to the hospital two month after the discharge. Sex and age-matched healthy subjects were determined as the control group. Blood samples and FMD measurements were obtained from each participant. All subjects were divided into two groups according to the presence of ED determined by FMD measurements. These two groups were compared in terms of demographic features and the presence of recovered COVID-19 disease.Results: A total of 92 subjects were included in the study. ED (+) group was older (p=0.015) and more likely to have hypertension (p=0.044) and COVID-19 rate was higher in ED (+) group (p=0.009). While neutrophil count (p=0.047) and CRP (p=0.036) were higher, eGFR (p=0.044) was lower in ED (+) group. In the backward multivariable regression analysis, COVID-19 disease [OR=3.611, 95% CI: 1.069-12.198, p=0.039] and BMI [OR=1.122, 95% CI: 1.023-1.231, p=0.015] were independent predictors of ED.Conclusion: COVID-19 disease may cause ED which is the major underlying factor of cardiovascular diseases. Furthermore, COVID-19 disease may deteriorate the existing cardiovascular disease course. Detecting ED in the early phase or preventing by new treatment modalities may improve short and long-term outcome.
TCF7L2 Gene Polymorphism as a Risk for Type 2 Diabetes Mellitus and Diabetic Microvascular Complications
Authors: Aboelkhair Noran Talaat , Kasem Heba Elsayed , Abdelmoaty Amera Anwar , Eledel Rawhia Hassan 
Published: May 2021

Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition with various genetics and environmental influences that affects the capacity of the body to produce or use insulin resulting in hyperglycemia, which may lead to variable complications. It is one of the world’s rising health problems. There is emerging evidence that some genetic polymorphisms can impact the risk of evolving T2DM. We try to determine the relationship of (rs7903146) variant of the Transcription factor 7-like 2 (TCF7L2) gene with T2DM and its microvascular complications.Methods and Results: This case-control study included 180 subjects: 60 diabetic patients without complications, 60 diabetic patients with microvascular complications and 60 matched healthy controls. Genotypes of rs7903146 (C/T) SNP in the TCF7L2 gene were evaluated by real-time polymerase chain reaction via TaqMan allelic discrimination. Logistic regression was used to detect the most independent factor for development of diabetes and diabetic microvascular complications. Variant homozygous TT and heterozygous TC genotypes were significantly increased in diabetic without complications and diabetic with complications groups than controls (p=0.003, 0.001) respectively. The T allele was more represented in both patient groups than controls with no significant difference between patient groups. TT genotype as well as T allele was significantly associated with increased T2DM risk.Conclusion: The T allele of rs7903146 polymorphism of TCF7L2 confers susceptibility to development of T2DM. However, no significant association was found for diabetic complications.
Research Status, Key Technology and Its Application Prospect of Complex Products Assembly Quality Control and Prediction Based on Digital Twin
Authors: Guo Xuepeng , Liu Linyan , Wang Huifeng , Yuan Tangxiao 
Published: May 2021

Abstract
In order to solve the problem of unmeasurable assembly performance of complex product, the digital twin-driven assembly quality control and prediction of complex product is studied by means of cyber-physical fusion in the assembly workshop. The connotation of digital twin intelligent assembly is introduced, the current research status of complex product assembly quality is compared and analyzed, and three main key technologies for the assembly quality control of complex product are proposed: (1) multidimensional, multi-scale, multidisciplinary modeling and simulating of digital twin-driven assembly; (2) multi-source heterogeneous data collection, sensing and fusion for assembly processes; (3) data-driven decision making, feedback and optimization technology. Finally, the application of digital twin technology in the field of assembly quality control of complex product is prospected.
Prediction of Approximate Multiplier for 16-Bit DICOM Image Contrast Scaling Using Classical Machine Learning Approach
Authors: dominic maria , T DEEPA 
Published: May 2021

Abstract
The role of approximate arithmetic are involved when the processors are used for multimedia signal processing application. The impact of multiplier is very important in many processes done by these processors. The compressors are the core architecture for reduction stage if the multiplier width is increased. Later approximations are done in the compressor to limited error without affecting the signal standard. The design of scalable-split compressor is designed in this work and a counter matching method has been developed for approximation. The design of 32x32 and 16x16 multiplier with these new compressors are synthesised in 45nm Synopsis Design Compiler and shows an improvement of 25 % of Chip area and 27% power. The split-scalable architecture attempts to reduce the delay with trade-off in area and power. Mean Error Distance (MED) and Normalized Error Distance (NED) are the parameters that ensure the quality of any approximate arithmetic based design. 16-bit medical images are processed with both existing and proposed multipliers then the Peak Signal to Noise Ratio (PSNR) is compared. Finally with several input nature and targeted PSNR the best system is identified using classical machine learning model.
An Efficient Integrated Framework of Reliability-Based Robust Design Optimization for Computation-Intensive Structures
Authors: lai xiongming , Huang Ju , Wang Cheng , Zhang Yong 
Published: May 2021

Abstract
When carrying out robust design optimization for complex engineering structures, they are computed by finite element software and are always computation-intensive. Aim at this problem, the paper proposes an efficient integrated framework of Reliability-based Robust Design Optimization (RBRDO). Firstly, the conventional RBRDO problem is changed as percentile form, that is, the improved percentile formulation of computing the objective robustness and probabilistic constraints is presented by resorting to the employment of Performance Measure Approach (PMA). Secondly, the above improved RBRDO problem is simplified by a series of new approximation methods due to the need of reducing computation. An efficient approximation method is proposed to estimate PMA functions of the RBRDO formulation. Based on it, the above improved RBRDO problem can be transformed into a sequence of approximate deterministic sub-optimization problems, whose objective function and constraints are expressed as the approximate explicit form only in relation to the design variables. Furthermore, use the trust region method to solve the above sequence of sub-optimization. Lastly, several examples are used to demonstrate the effectiveness and efficiency of the proposed method.
Serum Dopamine Level in Acute Murine Toxoplasmosis
Authors: Omidian Mostafa , Asgari Qasem , Bahreini Mohammad Saleh , Moshki Shokoufeh , Sedaghat Bahareh , Sadati Seyed Jafar Adnani 
Published: May 2021

Abstract
Toxoplasmosis is a globally parasitic zoonotic disease transmitted by Toxoplasma gondii protozoa. This infection in its chronic form can cause a change in its host's specific behavior and is also associated with developing neuropsychological symptoms in humans. Changes in neurotransmitters' levels, especially dopamine, have been identified as a behavior change factor in the infected host. This study aimed to evaluate serum dopamine levels in acute murine toxoplasmosis. In this study, 50 mice infected with Toxoplasma were studied in 5 separate groups, and ten healthy mice were considered a control group. For five consecutive days after parasite injection, blood sampling and serum isolation were performed daily from one of the groups. Serum dopamine levels were measured by HPLC method. Statistical studies showed that serum dopamine on the first to the fourth day after parasite inoculation was the same as the control group, but the fifth day began to increase. The present study results indicate that dopamine production in mice infected with Toxoplasma gondii increases from day five after infection. This result suggests that in acute toxoplasmosis, dopamine production is low, and the trend of chronic disease increases dopamine production.
Phillygenin Alleviates Lipopolysaccharide-Induced Acute Pneumonia by Modulating the Tumor Necrosis Factor α Signaling Pathway
Authors: Wang Cong-jie , Tan Yu-jun , Lv Chang-jun , Liu Zhong , Zhang Gui-min , Li Bing-bing , Cheng Guo-liang 
Published: May 2021

Abstract
Purpose: There is an urgent need to develop effective anti-pneumonia drugs. Phillygenin (PHI) is derived from Forsythia suspense and possesses anti-inflammation, anti-oxidant bioactivities. In the present study, we aimed to evaluate the therapeutic potential of phillygenin (PHI) on lipopolysaccharide (LPS)-induced acute pneumonia.Methods: The molecular target of PHI was predicted by bioinformatic analysis. Hollow fiber-based ligand fishing (HFLF) strategy and luciferase reporter assay were further used to identify the target of PHI. LPS-induced acute pneumonia rat model and A549 cells model were used to evaluate PHI function. TNF-α pathway and apoptosis associated proteins were detected by Western Blot, immunofluorescence and immunohistochemistry. Cell cycle and cytokines were determined by flow cytometry.Results: The bioinformatic analysis and luciferase reporter assay identified that the target protein of PHI was pregnane X receptor (PXR) PHI could directly bind to PXR protein and inhibit NF-κB P65 activity. PHI significantly decreased the expression of phosphorylated JNK, P38, Erk, P65 in acute pneumonia rat model. PHI also declined the expression of Bax, Caspase-3 and Caspase-9 and repressed lung epithelial cell apoptosis induced by LPS in vivo and in vitro. In addition, PHI inhibited inflammation cytokines production including TNF-α, IFN-γ, IL-6, IL-1β and IL-18.Conclusions: PHI significantly alleviated LPS-induced lung injury in vivo by exerting anti-inflammatory effects. This is the first study to demonstrate that PHI, a small molecule natural product, significantly alleviates LPS-induced acute pneumonia by binding to PXR. Thus, PHI can be a novel therapeutic agent for pneumonia.