bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penalized Logistic Regressions with Technical Indicators Predict Up and Down Trends
Authors: Jiang Huifeng , Hu Xuemei , Jia Hong 
Published: December 2021

Abstract
Predicting up and down trends for stock prices is an important puzzle in the financial field. Hu & Jiang (2021) proposed logistic regression with 6 technical indicators to predict up and down trends for Google's stock prices. In this paper we further propose the five penalized logistic regressions with 19 technical indicators: ridge (L2), lasso (L1), elastic net(EN), smoothly clipped absolute deviation (SCAD) and minimax concave penalty (MCP) to improve the prediction accuracy. Firstly, we combine the iterative weighted least square algorithm with the coordinate descent algorithm, and apply a training set to obtain parameter estimators and probability estimators. Then we adopt a test set to construct confusion matrices and receiver operating characteristic (ROC) curves, and apply them to assess their prediction performances. Finally we compare the proposed five prediction methods with logistic regression, support vector machine (SVM) and artificial neural network (ANN) , and found that the MCP penalized logistic regression performs the best. Therefore, we develop a new efficient prediction method to predict up and down trends for stock prices.
Diagnostic Accuracy of Dual-energy CT for Bone Marrow Edema in Patients with Acute Knee Injuries: A Systematic Review and Meta-analysis
Authors: Chen Xuelong , Li Zhizhuo , Fang Hui , Yin Xiangyang , Li Chengxin , Shi Lijun , Fan Xiaoyu , Xu Xin , Gao Fuqiang , SUN WEI 
Published: December 2021

Abstract
Background: The prevalence of knee injury is high and early diagnosis is significant to guide clinical treatment. MRI is recognized as the gold standard for detecting bone marrow edema (BME) in patients with acute knee injury, but limitations still exist. Dual-energy CT (DECT) is investigated as a promising alternative.Methods: We systematically retrieved studies from EMBASE, Scopus, PUBMED, and the Cochrane Library and collected gray literatures. According to PRISMA-DTA guidelines, a systematic review was performed from inception to July 31, 2021, assessing the diagnostic accuracy of DECT for detecting BME in at least 10 adult patients with acute knee injuries and with an MRI reference standard. Study details were independently extracted by two reviewers. Meta-analysis was performed using a bivariate mixed-effects regression model with subgroup analysis performed to evaluate for sources of variability. Results: Nine studies evaluating 290 patients between the ages of 23–53 with acute knee injuries undergoing DECT and MRI were included in analysis. Summary sensitivity, specificity, and AUC values for BME were 85% (95% confidence interval (CI) 77–90%), 96% (95% CI 93–97%), and 0.97 (95% CI 0.95–0.98), respectively. There were no statistically significant differences in specificity and sensitivity amongst comparative subgroups to account for presumed variability amongst studies.Conclusion: DECT is accurate for detecting BME in patients with acute knee injuries and can be used as an alternative to MRI, particularly when MRI is contraindicated or unavailable.
Bimetallic Fe/Al-MOF for the Adsorptive Removal of Multiple Dyes: Optimization and Modeling of Batch and Hybrid Adsorbent-river Sand Column Study
Authors: Singh Hemant , Raj Sankalp , rathour Rishi karan singh , Bhattacharya Jayanta 
Published: December 2021

Abstract
Bimetallic Metal organic framework (MOF) has garnered interest over the years with its application in various environmental remediation. In this study, Fe-Al-1,4-Benzene di-Carboxylic acid (FeAl(BDC)) MOF was synthesized, and adsorptive removal of Rhodamine B dye in batch and unique hybrid FeAl (BDC)-River sand fixed-bed column was achieved. The experimental data from the batch studies corroborated well with the Pseudo second-order (PSO) and Freundlich adsorption isotherm models. Furthermore, a fixed-bed column study was conducted to assess the effect of varying flow rate (2, 5, 8 mL/min), bed height (5, 9, 13 cm), and feed concentration (10, 20, 30 mg/L) on the adsorption performance of FeAl(BDC) in continuous mode of operation. A uniform mixture of river sand and FeAl(BDC) by weight ratio (9:1) was achieved prior to packing the column. The column study reveals that Sand-FeAl(BDC) can achieve the maximum adsorption capacity of 113.05 mg/g at a flow rate of 5 mL/min, feed concentration of 20 mg/L, and bed height of 13 cm. The experimental data of the column study were successfully fitted with BDST, Thomas, Yoon-Nelson, and Dose-response models. The fitting parameter values from the BDST model raise the scope of possible upscaling of the fixed-bed column. Hence, it is proposed that these River sand-FeAl(BDC)-based filters can be widely used in areas facing critical contamination and in poor communities with a high demand for water.
Nanomaterials for Sustainability: A Review on Green Synthesis of Nanoparticles Using Microorganisms
Authors: Jadoun Sapana , Chauhan Narendra Pal Singh , Zarrintaj Payam , Barani Mahmood , Varma Rajender S. 
Published: December 2021

Abstract
Nanotechnology has permeated all areas of sciences as one of the most propitious technology with the deployment of nanoparticles in environmental remediation and biomedical fields; their synthesis under greener conditions has been bourgeoned using microorganisms, plants, etc. to decrease the use of toxic chemicals. Synthesis of nanoparticles by exploiting microorganisms has opened up a new prospect at the interface of nanotechnology, chemistry, and biology enabling access via a biocompatible, safe, sustainable, eco-friendly, and reliable route; microorganisms offer crystal growth, stabilization, and prevention of aggregation thus performing a dual role of reducing and capping agent because of the presence of biomolecules such as enzymes, peptides, poly (amino acids), polyhydroxyalkanoate (PHA), and polysaccharides. Herein, the microorganisms-based synthesis of various nanoparticles comprising gold, silver, platinum, palladium, copper, titanium dioxide, zinc oxide, iron oxide, and selenium along with their appliances in waste treatment, biomedicine namely cancer treatment, antibacterial, antimicrobial, antifungal, and antioxidants, are deliberated.
Gingival Epithelial Cell-Derived Microvesicles Activate Mineralization in Gingival Fibroblasts
Authors: Kobayashi Shuichiro , Bi Jiarui , Owen Gethin , Larjava Nelli , Koivisto Leeni , Häkkinen Lari , Larjava Hannu 
Published: December 2021

Abstract
Soft tissue calcification occurs in many parts of the body, including the gingival tissue. Epithelial cell-derived MVs can control many functions in fibroblasts but their role in regulating mineralization has not been explored. We hypothesized that microvesicles (MVs) derived from gingival epithelial cells could regulate calcification of gingival fibroblast cultures in osteogenic environment. Human gingival fibroblasts (HGFs) were cultured in osteogenic differentiation medium with or without human gingival epithelial cell-derived MV stimulation. Mineralization of the cultures, localization of the MVs and mineral deposits in the HGF cultures were assessed. Gene expression changes associated with MV exposure were analyzed using gene expression profiling and real-time qPCR. Within a week of exposure, epithelial MVs stimulated robust mineralization of HGF cultures that was further enhanced by four weeks. The MVs taken up by the HGF's did not calcify themselves but induced intracellular accumulation of minerals. HGF gene expression profiling after short exposure to MVs demonstrated relative dominance of inflammation-related genes that showed increases in gene expression. In later cultures, OSX, BSP and MMPs were significantly upregulated by the MVs. These results suggest for the first time that epithelial cells maybe associated with the ectopic mineralization process often observed in the soft tissues.
In Vitro Assessment of 17 Antimicrobial Agents Against Clinical Mycobacterium Avium Complex Isolates
Authors: Lin Siran , Hua Wenya , Wang Shiyong , Zhang Yu , Chen Xinchang , Liu Hong , Shao Lingyun , Chen Jiazhen , Zhang Wenhong 
Published: December 2021

Abstract
Background: Recently, Mycobacterium avium complex (MAC) infections have been increasing, especially in immunocompromised and older adults. The rapid increase has triggered a global health concern due to limited therapeutic strategies and adverse effects caused by long-term medication. To provide more evidence for the treatment of MAC, we studied the in vitro inhibitory activities of 17 antimicrobial agents against clinical MAC isolates.Results: A total of 111 clinical MAC isolates were enrolled in the study and they were identified as M. intracellulare, M. avium, M. marseillense, M. colombiense, M. yongonense, M. arosience, and one isolate was undifferentiated at subspecies level. MAC strains had relatively low (0–21.6%) resistance to clarithromycin, amikacin, bedaquiline, rifabutin, streptomycin, and clofazimine, and the resistant rates to isoniazid, rifampin, linezolid, doxycycline, and ethionamide were very high (72.1–100%). In addition, M. avium and M. intracellulare had different resistance profiles for clarithromycin, ethambutol, trimethoprim/sulfamethoxazole, amikacin, linezolid, clofazimine, cycloserine, and ethionamide. Conclusions: Our results supported the current usage of macrolides, rifabutin, and aminoglycosides in the regimens for MAC infection, and also demonstrated the low resistance rate against new drugs, such as clofazimine, tedizolid, and bedaquiline, suggesting the possible implementation of these drugs in MAC treatment.
PA1 Participates in the Maintenance of Blood-Testis Barrier Integrity via Cooperation with JUN in the Sertoli Cells of Mice.
Authors: Liu Bo , Liu Chao , Ma Binfang , Zhang Ruidan , Zhao Zhiwei , Xiao Sai , Cao Wanjun , Ma Yanjie , Zhu Guozhang , Li Wei , Li Zhen 
Published: December 2021

Abstract
BackgroundThe blood-testis barrier (BTB) is essential to the microenvironment of spermatogenesis, and Sertoli cells provide the cellular basis for BTB construction. Numerous nuclear transcription factors have been identified to be vital for the proper functioning of Sertoli cells. PA1 has been reported to play important roles during diverse biological processes, yet its potential function in male reproduction is still unknown. ResultsHere, we show that PA1 was highly expressed in human and mouse testis and predominantly localized in the nuclei of Sertoli cells. Sertoli cell-specific Pa1 knockout resulted in an azoospermia-like phenotype in mice. The knockout of this gene led to multiple defects in spermatogenesis, such as the disorganization of the cytoskeleton during basal and apical ectoplasmic specialization and the disruption of the BTB. Further transcriptomic analysis, together with Cut-Tag results of PA1 in Sertoli cells, revealed that PA1 could affect the expression of a subset of genes that are essential for the normal function of Sertoli cells, including those genes associated with actin organization and cellular junctions such as Connexin43 (Cx43). We further demonstrated that the expression of Cx43 depended on the interaction between JUN, one of the AP-1 complex transcription factors, and PA1. ConclusionOverall, our findings reveal that PA1 is essential for the maintenance of BTB integrity in Sertoli cells and regulates BTB construction-related gene expression via transcription factors. Thus, this newly discovered mechanism in Sertoli cells provides a potential diagnostic or even therapeutic target for some individuals with azoospermia.
Identification of Hub Genes And Potential Molecular Mechanisms In Peripheral Blood Mononuclear Cells of Patients With Parkinson’s Disease
Authors: Li Zhi-Hui , Wang Guang-Tian , Chi Chun-Ling , Zhou Yu-Nan , Liu Dan , Wang Feng-Shuang , Liu Bin 
Published: December 2021

Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease. The pathogenesis of PD remains elusive, however PD appears to be caused by a complex interaction between environmental and genetic factors affecting various biological processes. The purpose of the present study is to identify hub genes and potential molecular mechanisms in peripheral blood mononuclear cells (PBMCs) of PD patients to aid early diagnosis and start treatment promptly. Two gene expression profiles (GSE22491 and GSE100054) were obtained from the Gene Expression Omnibus (GEO) database, in which 20 PBMC samples from PD patients and 17 controls were included, and the genes were analyzed with GEO2R. 1382 and 512 differentially expressed genes (DEGs) were identified in GSE22491 and GSE100054, respectively. Additionally, a total of 80 significant DEGs were found to co-exist in the two microarray datasets via Venn diagram. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, which showed that the DEGs were mainly enriched in platelet degranulation, blood coagulation, nitric oxide mediated signal transduction, positive regulation of GTPase activity and cellular response to lipopolysaccharide. PPI network, microRNA (miRNA) - hub gene network, and transcription factor (TF)- hub gene network were constructed. In summary, the present study provides data of potential diagnostic biomarkers and therapeutic targets for PD. SRC may be a potential target for the treatment of PD. Additionally, three TFs (HNF4A, CDX2 and FUS), three miRNAs (hsa-miR-16-5p, hsa-miR-103a-3p and hsa-miR-107), may be involved in PD.
Adsorption Free Energy of Glycine on TiO2 in Water from First Principles Simulations and Electrochemical Impedance Spectroscopy
Authors: Agosta Lorenzo , Fiore Luca , Colozza Noemi , Lyubartsev Alexander , Arduini Fabiana , Hermansson Kersti 
Published: December 2021

Abstract
The adhesion of amino acids and small organic molecules on TiO2 nanoparticles is fundamental for bio-nano functionalization of peptides and proteins. The adsorption free energy is the main physical quantity that regulates the adsorption process. Its evaluation is particularly challenging both experimentally, due to the weak interfacial signal in aqueous environments, and by atomistic simulations, due to the complexity of the physical phenomena occurring at the solid-water interface (polarization and charge transfer effects). We report here an accurate experimental-computational study of hydrated TiO2 nanoparticles interacting with Glycine where we obtain quantitative agreement of the measured adsorption free energy. Ab-initio simulations are performed within the Tight Binding Density Functional Theory in combination with enhanced free energy sampling techniques. The experiments adopt a new and efficient set-up for electrochemical impedance spectroscopy measurements based on screen-printed gold electrodes. The measured adsorption free energy is about -30 kJ/mol (both from experiment and calculation), with preferential interaction of the charged NH3 group which strongly adsorbs on the TiO2 bridging oxygens. The perfect agreement between computation and experiment opens the doors to an extended exploration of the bio-nano interaction for different materials and molecules.
Prognostic Impact of Pelvic Lymph Node Dissection During Radical Prostatectomy on Patients With High-risk Prostate Cancer Treated With Neoadjuvant Chemohormonal Therapy
Authors: Iwamura Hiromichi , Hatakeyama Shingo , Narita Takuma , Ozaki Yusuke , Konishi Sakae , Horiguchi Hirotaka , Kodama Hirotake , Kojima Yuta , Fujita Naoki , Okamoto Teppei , Tobisawa Yuki , Yoneyama Tohru , Yamamoto Hayato , Yoneyama Takahiro , Hashimoto Yasuhiro , Ohyama Chikara 
Published: December 2021

Abstract
BackgroundWe aimed to determine the prognostic and staging benefit of limited pelvic lymph node dissection (PLND) during radical prostatectomy (RP) in high-risk prostate cancer (PC) patients treated with neoadjuvant chemohormonal therapy.MethodsWe retrospectively analyzed 516 patients with high-risk localized PC (<cT4N0M0) who received neoadjuvant androgen-deprivation therapy plus estramustine phosphate followed by RP between January 2010 and March 2020. Since we stopped limited-PLND for such patients in October 2015, we compared the biochemical recurrence-free survival (BCR-FS) between the limited-PLND group (before October 2015, n = 283) and the non-PLND group (after November 2015, n = 233).ResultsThe rate of node metastases in the limited-PLND group were 0.8% (2/283). Operation time was significantly longer (176 vs. 162 min) and the rate of surgical complications were much higher (all grades; 19 vs. 6%, grade ≥ 3; 3 vs. 0%) in the limited-PLND group. The inverse probability of treatment weighting-Cox analysis revealed limited PLND had no significant impact on BCR-FS (hazard ratio, 1.31; P = 0.421).ConclusionsLimited PLND during RP after neoadjuvant chemohormonal therapy showed a relatively low rate of positive nodes, higher rate of complications, and no significant impact on BCR-FS.
Risk of Adverse Fetal Outcomes Following Nonobstetric Surgery During Gestation: A Nationwide Population-Based Analysis
Authors: Fu Pei-Han , Yu Chia-Hung , Chen Yi-Chen , Chu Chin-Chen , Chen Jen-Yin , Liang Fu-Wen 
Published: December 2021

Abstract
Background: Literature suggests that nonobstetric surgery during gestation is associated with a higher risk of spontaneous abortion, prematurity, and a higher cesarean section rate, but the direct impact on fetal outcomes is still unclear. In this study, we aimed to investigate whether nonobstetric surgery during pregnancy is associated with negative fetal outcomes by analysing a nation-wide database in Taiwan.Methods: This population-based retrospective observational study was based on the linkage of Taiwan’s National Health Insurance Research Database, Birth Reporting Database, and Maternal and Child Health Database between 2004 and 2014. For every pregnancy with nonobstetric surgery during gestation, four controls were randomly matched according to maternal age and delivery year. We estimated adjusted odds ratios (aOR) and 95% confidence intervals (CIs) of adverse fetal outcomes with the non-surgery group as the reference. The primary outcomes involved stillbirth, prematurity, low birth weight, low Apgar scores, and neonatal and infant death.Results: Among 23,721 identified pregnancies, 4,747 underwent nonobstetric surgery. Pregnancies with nonobstetric surgery had significantly higher risks of prematurity (aOR: 1.46; 95% CI: 1.31–1.62), lower birth weight (aOR: 1.49; 95% CI: 1.33–1.67), Apgar scores <7 (1 min, aOR: 1.58; 95% CI: 1.33–1.86; 5 min, aOR: 1.34; 95% CI: 1.03–1.74), neonatal death (aOR: 2.01; 95% CI: 1.18–3.42), and infant death (aOR: 1.69; 95% CI: 1.12–2.54) than those without nonobstetric surgery after adjustment for socioeconomic deprivation, hospital level, and other comorbidities. Surgery performed in the third trimester was associated with a significantly increased rate of prematurity (aOR: 1.38; 95% CI: 1.03–1.85), but lower rates of stillbirth (aOR: 0.1; 95% CI: 0.01–0.75) and Apgar score <7 at the 5th minute (aOR: 0.2; 95% CI: 0.05–0.82), than surgery performed in the first trimester.Conclusions: Pregnancies with nonobstetric surgery during gestation were associated with increased risks of prematurity, low birth weight, low Apgar scores, neonatal and infant death, longer admission, and higher medical expenses than those without surgery. Furthermore, surgery in the third trimester was associated with a higher rate of prematurity than surgery performed in the first trimester.Trial registration: Not applicable
Attitude Towards Electronic-Prescription and Associated Factors Among Physicians at University of Gondar Referral Hospital: Institution Based Cross-Sectional Study
Authors: Zimamu Libsuye Yalgaw , Wubet Gashaw Mehiret 
Published: December 2021

Abstract
Background: Electronic prescription is described by the United States Centers for Medicare and Medicaid Services as the broadcast utilizing electronic medium, of prescription or prescription-related information between prescriber, distributor, pharmacy benefit manager, or health plan, either openly or through an agent, including an electronic prescribing system. the aim of this study was designed to assess attitudes towards electronic prescription and associated factors among physicians at the University of Gondar referral hospital 2021. Gondar, Ethiopia.Methods: Hospital-based Cross-sectional study was used among (n=152) physicians who have involved with a response rate of 88.8%. Data were collected using structured self-administered questionnaires from August 1 to September 1/2021. The collected data were entered into Epi-info Version 7.2 and exported to SPSS version 23 software for analysis. Descriptive statistics using frequency and other summary statistics were using present socio-demographic and clinical characteristics of participants. Bivariate and multivariable logistic regression was employed to identify factors associated with dependent variables. Odds ratio (OR), with 95% CI and p value< 0.05 were computed to determine the level of significance.Results: Based on the operational definition the overall score of attitudes to an electronic prescription of physicians from the University of Gondar referral hospital was 76.8% [95% CI: 66.7-84.2]. Among the applicant variables for multivariable analysis two variables like age of the respondents [AOR: 2.48 (95% CL:1.055-5.830], and the monthly salary of the respondents [AOR: 8.29(95%CL: 3.002-22.89] had to have a significant association with electronic prescription.Conclusion and recommendation: The overall score of attitudes to the electronic prescription of physicians from the University of Gondar referral hospital was good. Age and a monthly salary of the respondents were significantly associated with an electronic prescription from the working organization university of Gondar referral hospital, and health care policymakers and hospital managers need to develop and institutionalize evidence-based widespread preparation of stakeholders especially prescribers and communications development earlier than its acceptance to build it doing well and victorious.
Prevalence of Self-Neglect and Associated Factors Among Disability Elderly in China
Authors: Dong Li , Sun Longfeng 
Published: December 2021

Abstract
Purpose: To assess the prevalence of self-neglect and associated factors among disability elderly(age≥65 years) in China.Patients and methods: Patients aged 65 years or above were enrolled from two communities in Shenyang,China. A convenience sample of 230 disability elderly responded to the questionnaire survey. The data were collected by a series of questionnaires consisting of socio-economic and demographic characteristics, Barthel Index(BI), Elder Self-Neglect Assessment(ESNA), Geriatric Depression Scale-Short Form(GDS-SF), Multidimensional Scale of Perceived Social Support(MSPSS), and Mini-Mental State Examination(MMSE). Kruskal-Wallis test or Mann-Whitney U test was used to examine the differences of self-neglect among different demographic characteristics as appropriate.Multiple linear regression model was performed to identify which factors were independent predictors of self-neglect.Results: An overall self-neglect rate of 86.0% was registered. The study reveals that disability elderly's self-neglect correlates positively with the degree of disability and depressive symptoms. On the contrary, monthly income and perceived social support were negatively associated with self-neglect.Conclusion: In this study, the prevalence of self-neglect is high among disability elderly. Lower monthly income, decreased physical functioning, depressive symptoms, and poor perceived social support were contributing factors for self-neglect among disability elderly.