bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology evaluation and impact assessment of innovative wastewater treatment and resource recovery systems in Kanpur, India
Authors: Breitenmoser Lena , Rohrer Karina , Hooijmans Christine M. , Campling Paul , Kumar M. Dinesh , Anshuman  , Kazner Christian , Hugi Christoph 
Published: December 2024

ABSTRACT

Resource recovery from wastewater treatment plants is crucial for India's circular economy, as emphasized by the national draft water reuse norms 2024. This study evaluated resource recovery technologies using circularity and sustainability assessment methods to inform technology selection. A multiple-criteria decision analysis compared three innovative and two reference treatment trains in Kanpur, India, based on treatment performance, costs, and resource recovery potential. Quantitative microbial risk and life cycle assessments further evaluated health and environmental benefits and burdens. Innovative systems, such as Andicos (ultrafiltration + co-digestion) and SFD-MBR (slow-forming dynamic membrane bioreactor) had slightly lower performance indices (ΔPI: 0.10–0.12) than the reference system MBR due to lower nutrient removal. The innovative systems generated 1.3 to 2 times more revenue from selling water, nutrients, and energy. Further, reusing nutrient-rich treated effluents for irrigation reduced eutrophication potential by 94%. Treatment trains with constructed wetland plus (CW+) achieved the highest faecal coliform (FC) removal, meeting reuse norms of &lt;5 MPN/100 mL, potentially preventing up to 2,600 gastrointestinal infections annually among 4,000 farmers using the water for irrigation. This study highlights the potential environmental, health, and economic benefits of innovative wastewater treatment technologies for advancing resource recovery in India.
Exploring the Mechanism of the Safflower against Melanoma using
Network Pharmacology and Molecular Docking
Authors: Zhang Yun-Chao , Xu Si-Yu , Yang Min , He Yan-Ming , Mo Da-Yu 
Published: December 2024

Background:
Traditional Chinese medicine rarely applies the herb Safflower (Carthamus
tinctorius) to the treatment of tumors and little is known about its mechanisms and the treatment of
Safflower for melanoma.

Objective:
This study aims to analyze the active ingredients and underlying mechanisms of Safflower
in treating melanoma using network pharmacology, molecular docking, and in vitro experiments
and provide a new direction for the research and development of new drugs for melanoma treatment

Methods:
We collected the active chemical ingredients from Safflower and generated a network of
"Drug-Active Ingredient-Target" by Cytoscape. From the DrugBank, OMIM, and GeneCard databases,
disease-related targets of melanoma were obtained. The intersection target genes between
Safflower and melanoma were identified, leading to the construction of a protein-protein interaction
(PPI) network via Cytoscape software. Metascape database was used to enrich pathways for relative
targets of Safflower. Molecular docking was demonstrated by the software AutoDockTools-1.5.6.
Use an online database (https://xenabrowser.net/) and R package IOBR (version 0.99.9) to evaluate
the correlation between the core target genes and prognosis or the immune score. CCK8 and PCR
were used to detect the toxicity of quercetin on melanoma cells and its effects on mRNA expression
of AKT1, JUN, and TP53.

Results:
Our investigation identified 17 active pharmaceutical ingredients within Safflower alongside
94 potential targets related to melanoma treatment. Gene Ontology (GO) analysis is primarily
concerned with extracellular exosomes, positive regulation of transcription from RNA polymerase II
promoter, and protein binding. KEGG pathway enrichment analysis mainly involves Pathways in
cancer, IL-17 signaling pathway, AGE-RAGE signaling pathway, and other pathways. Using molecular
docking, it can be seen that the compounds Quercetin, kaempferol, luteolin, baicalein, and betasitosterol
in Safflower have strong binding abilities with important targets. The results of survival
analysis and immune score analysis suggest that Safflower may regulate the immune cell infiltration
of melanoma patients by acting on core target genes and improving the prognosis of patients. In vitro
analysis confirmed that Quercetin was cytotoxic toward B16-F10 cells and altered mRNA expression
of AKT1, JUN, and TP53 identified through the network pharmacology approach.

Conclusion:
This work offered an active pharmaceutical ingredient in Safflower and potential targets
for melanoma, and the mechanism of its action on melanoma may be related to the regulation of
immune-related pathways in melanoma.
Korelasi Antara Statistik Vital Dengan Lingkar Skrotum Pada Kambing Peranakan Etawah dan Lokal di Kecamatan Wonosari Kabupaten Malang
Authors: Darmawan Drajad Azis , Ciptadi Gatot , Budiarto Agus , Mudawamah Mudawamah 
Published: December 2024

Tujuan penelitian ini untuk mengkaji performans kambing Peranakan Etawah (PE) dan Lokal dengan menganalisis hubungan antara ukuran statistik vital berupa lingkar dada (LD), panjang badan (PB) dan tinggi badan (TB) dengan lingkar skrotum (LS). Terdapat 100 ekor kambing Jantan yang digunakan sebagai materi penelitian yang terdiri dari 50 ekor kambing PE dan 50 ekor kambing Lokal yang dikelompokkan menjadi 3 kelompok, yaitu PI1 (kambing umur 12-18 bulan), PI2 (kambing umur >18-24 bulan) PI3 (kambing umur >36 bulan) sebagai sampel dari beberapa desa di kecamatan Wonosari. Data dianalisa menggunakan klasifikasi satu arah dan dilanjutkan dengan analisa korelasi dan regresi untuk mengetahui hubungan setiap variabel yang diamati. Hasil penelitian menunjukkan bahwa terdapat korelasi positif antara LD dengan LS pada kambing PE dan Lokal sebesar r = 0,73 (P<0,01) dengan persamaan regresi Y = 19,16 + 0,01X. PB dengan LS pada kambing PE dan Lokal memiliki nilai korelasi sebesar r = 0,66 (P<0,01) dengan persamaan regresi Y = 11,62 + 0,15X. TB dengan LS pada kambing PE dan Lokal memiliki nilai korelasi sebesar r = 0,78 (P<0,01) dengan persamaan regresi Y = 8,61 + 0,17X. Kesimpulan pada penelitian ini adalah terdapat korelasi antara statistik vital dengan lingkar skrotum pada kambing PE dan Lokal.
Promoting mental health at work in Finland
Authors: Vastamäki Jaana 
Published: December 2024

This career path interview describes the work of an expert in work and organizational psychology in the Finnish central government at the Ministry of Social Affairs and Health. Research and policy are combined in the work of the Ministry’s senior specialist. Mental health problems are a key factor causing sick leaves in Finnish work life and promoting mental health and preventing problems are a key objective that is promoted through various practical measures.
Smartphone-Based Care Platform Versus Traditional Care in Primary Knee Arthroplasty in the United States: Cost Analysis
Authors: Lonner Jess H , Naidu-Helm Ashwini , Van Andel David , Anderson Mike B , Ditto Richard , Redfern Roberta E , Foran Jared 
Published: December 2024

Abstract
Cost savings were achieved with the use of a smartphone-based care management platform, considering several health care resources following knee arthroplasty procedures without negatively impacting clinical outcomes.
Adverse Pregnancy Outcomes in Overweight and Obese Pregnant Women in a Tertiary Care Center of Western Nepal: A Prospective Cohort Study
Authors: Shrestha Deepak , Singh Kritina , Aryal Shreyashi 
Published: December 2024

Introduction: Maternal obesity is an established risk factor for various adverse pregnancy outcomes. Increased chances of labour induction, prolonged labour, instrumental and cesarean deliveries, medical disorders of pregnancy, post partum haemorrhage, preterm deliveries, macrosomia, low Apgar score etc. are well recognised risks of maternal obesity. This study aimed to evaluate these maternal and fetal outcomes in relation to the body mass index (BMI) of parturients. Methods: A prospective cohort study involving 115 overweight and obese women was conducted. Various maternal and fetal outcomes were studied and compared with those of 115 postpartum women with normal BMI. Statistical analysis was done using student's t-test and Chi square test. Binomial logistic regression analysis was carried out to examine the magnitude and significance of the independent effect of BMI. Results: The three groups were comparable in terms of maternal age and gestational age at delivery. The total blood loss was significantly higher in the obese group as compared to the normal BMI (p=0.001) or overweight groups (p=0.005). Vaginal delivery was 69% less common in obese group in comparison to normal BMI group. The prevalence of meconium stained liquor, labour induction, preterm labour, and admission to neonatal intensive care unit were not significantly different across the three groups. Conclusion: This study highlighted the increased risk of total blood loss and birth weight >3500 grams with increasing BMI of pregnant women. A multicentric prospective study with larger sample size would shed further light on the strength of association between maternal BMI and various outcomes.
Patients’ perspectives of the long-term impact of orthodontic treatment: a qualitative study
Authors: Mohammed Hisham , Morsi Ahmed , Wafaie Khaled , Daniel Ben K. , Farella Mauro 
Published: December 2024

ABSTRACT

Objectives
To explore how orthodontic treatment affects different aspects of life, such as self-esteem, well-being, and social interactions and, additionally, to identify the long-term challenges that orthodontic patients experience after treatment.

Materials and Methods
This qualitative study involved in-depth semistructured face-to-face interviews. A purposive sampling strategy aimed to recruit a representative cohort of orthodontic patients who had their orthodontic treatment in adolescence and had their treatment concluded at least 5 years previously. Twenty-one patients (13 females and 8 males) were interviewed using a prepiloted topic guide. These interviews were transcribed and analyzed verbatim, using the general inductive method of data analysis.

Results
The thematic analysis revealed four key themes and related subthemes: (1) self-confidence and interpersonal communication, (2) social and professional opportunities, (3) oral health and function, and (4) challenges. In-depth analysis revealed positive treatment outcomes regarding enhanced self-confidence, social interactions, and perceived improvement in oral health and function. It also highlighted ongoing challenges with retainers and dissatisfaction with relapse.

Conclusions
Orthodontic treatment can significantly impact patient lives. Orthodontic patients described direct long-term positive effects on their social lives and well-being. However, it is equally important to remain mindful of the long-term challenges that may arise after treatment, especially with retainer choices and relapse, enabling proactive measures to mitigate their impact.
Canva-based Digital Storybooks to Improve Pancasila Education Learning Outcomes for Fifth Grade of Elementary School
Authors: Damarsari Noviana Astuti , Widodo Susilo Tri 
Published: December 2024

Learning media is an important component in learning to stimulate students to learn and learning objectives can be achieved. This research aims to develop digital storybook learning media on Pancasila Education subject content that is good, effective, and quality, to support the improvement of student learning outcomes. This type of research falls into the category of research and development (R&D) by applying the Borg and Gall model. Respondents in this study were fifth grade students with a total of 20 students. Then this research involves media experts and material experts to provide validation of the developed media. The data collection process in this study was carried out through interviews, expert validation, response questionnaires, and pretest and post-test sheets. This research resulted in, among others: digital storybooks are very feasible to use and this can be seen from the assessment obtained from learning material content experts who obtained a percentage of 90.38% (very feasible) and learning media experts obtained a percentage of 90.38% (very feasible); from the results of digital storybook responses rated very practical; digital storybooks are proven to be effective based on the results of the N-gain test, where there is an increase in the average value of the post-test with the average value of the pretest. This shows that digital storybook learning media is very feasible to use and can improve the learning outcomes of fifth grade students on the content of Pancasila Education.
INOVAÇÕES TECNOLÓGICAS EM SEGURANÇA URBANA
Authors: Brandão Rafael Gueller Araujo , Hardt Letícia Peret Antunes , Hardt Carlos 
Published: December 2024

Nas últimas décadas, as cidades brasileiras têm sido sujeitas a expressivo número de crimes de oportunidade, notadamente de furtos e roubos, comuns em espaços públicos. Perante essa problemática, objetiva-se analisar avanços teórico-conceituais e técnico-processuais na integração de tecnologias voltadas à segurança urbana. Com caráter exploratório e natureza qualitativa, a pesquisa foi apoiada em procedimentos de sistema metodológico específico para revisão sistemática de produções acadêmicas e institucionais disponíveis em repositórios internacionais e restritas aos últimos 10 anos. Os resultados alcançados revelam a gênese de nova área de conhecimento, que relaciona prevenção criminal, morfologia espacial e mobilidade urbana. Esses achados permitem a formulação de respostas à pergunta investigativa sobre quais condições recentes indicam possibilidades de uso conjunto de soluções pautadas em inovações tecnológicas. Conclui-se pela necessidade de desenvolvimento de estudos empíricos, contribuindo no suporte a reconhecimentos científicos e processos decisórios, a partir de ferramentas inovadoras de gestão, planejamento e projeto de urbes contemporâneas no país.
Sistem Penjaminan Mutu Pendidikan di MTs Riyadush Sholihin Purwareja Klampok Banjarnegara
Authors: Sudiro Sudiro , Zahra Alya Az 
Published: December 2024

Abstract

The quality of education is related to whether or not the goals of national education are achieved as stated in Law No. 20 of 2003 concerning the National Education System. Therefore, the quality of education can be said to be good if it meets the National Education Standards. Fulfillment of the minimum standard of education which is the National Education Standard is a requirement to improve the quality of education including madrasah. The reality that emerges is that the quality of education in Indonesia is still quite far from what was expected, moreover the quality in most madrasas is still experiencing many problems. Many madrasahs do not meet standardized qualifications and competencies, as well as inadequate facilities and infrastructure. This paper aims to describe the role of the education quality assurance system in improving the quality of education in madrasas.
Keywords: Quality, Education, Madrasah, National Standards.

Abstrak
Mutu pendidikan berkaitan dengan tercapai atau tidaknya tujuan pendidikan nasional seperti yang tercantum di dalam UU Nom 20 Tahun 2003 tentang Sistem Pendidikan Nasional. Oleh karena itu, mutu pendidikan dapat dikatakan baik apabila memenuhi Standar Nasional Pendidikan. Terpenuhinya standar minimal pendidikan yang merupakan Standar Nasional Pendidikan merupakan persyarat untuk meningkatkan mutu pendidikan termasuk madrasah. Realitas yang muncul bahwa mutu pendidikan di Indonesia masih cukup jauh dari yang diharapkan, apalagi mutu di kebanyakan madrasah yang masih banyak mengalami kendala. Banyak madrasah yang belum memenuhi kualifikasi dan kompetensi yang distandarkan, serta sarana dan prasarana yang belum memadai. Tulisan ini bertujuan untuk mendeskripsikan bagaimana peran sistem penjaminan mutu pendidikan dalam meningkatkan mutu pendidikan di madrasah. Kata Kunci : Mutu, Pendidikan, Madrasah, Standar Nasional.
Pendidikan Kesehatan Gigi Dan Mulut Pada Anak Usia PAUD
Authors: Sinawang Gabriel Wanda , Teju Selly Omega Dila , Prasanti Anastasia Nimas 
Published: December 2024

Abstrak: Karies gigi adalah salah satu permasalahan yang masih sering ditemukan pada anak usia dini. Pemberdayaan kesehatan gigi dan mulut pada anak usia dini sangat penting dan membutuhkan kerja sama orang tua dan tenaga kesehatan dalam proses belajar menyikat gigi. TK Among Siswa merupakan salah satu tempat pendidikan anak usia PAUD (Pendidikan Anak Usia Dini) yang berlokasi di Surabaya. Tujuan pemberian edukasi praktik perawatan gigi dan mulut pada anak usia PAUD diharapkan menjadi bekal pengetahuan untuk dapat diterapkan selama proses pertumbuhan dan perkembangan anak usia dini terutama dalam peningkatan kesehatan gigi dan mulut. Kegiatan pemberian edukasi kesehatan gigi dan mulut dilakukan melalui praktik demonstrasi menggosok gigi. Hasil dari kegiatan pemberian edukasi dengan metode demonstrasi, menghasilkan peningkatan pengetahuan dan tindakan siswa dalam melakukan tahapan menggosok gigi dengan baik dan benar. Para siswa antusias dan bersemangat dalam mengikuti kegiatan edukasi dan demonstrasi menggosok gigi dan mulut.
El acierto de Damasio: la información del afecto
Authors: Melamed Andrea F 
Published: December 2024

El libro de Antonio Damasio El error de Descartes (1994) constituye un hito en las discusiones en torno a la concepción de la mente humana en general y a las emociones en particular, tanto por su caracterización de las mismas como por el papel que desempeñan para nuestra economía mental.
En este artículo me propongo continuar el espíritu de la apuesta de Damasio para mostrar que las emociones no solamente son indispensables para la toma de decisiones y el cálculo racional, sino que son esenciales para la agencialidad toda. Para ello, comenzaré ofreciendo una breve reconstrucción de su propuesta, remarcando sus avances sobre la intuición original jamesiana (apartado 1). En segundo lugar, me ocuparé de señalar el valor de las emociones para la agencialidad sintetizando el aporte directo que Damasio realizó con su hipótesis de los marcadores somáticos y, en segundo lugar, recogiendo otras contribuciones que refuerzan la tesis de la influencia de las emociones sobre otros aspectos de nuestra vida mental (apartado 2). En la sección final (apartado 3) sugeriré una clave de reinterpretación de los fenómenos presentados, con el fin de integrar lo que considero fue la hazaña de Damasio, me refiero a la revolución implantada en el seno mismo de la conceptualización de las emociones y su importancia para la agencialidad.
Justifying the Necessity of Anti-Abortion Legislation: An Exploratory Analysis of Moral Panic Style in American Pro-Life Advocacy and Media Discourses
Authors: Pîrciu Alexandru 
Published: December 2024

Abstract
Since the 1980s, abortion has been “labeled a source of great and bitter political conflict” (Gusfield, 1981). After Dobbs v. Jackson Women’s Health Organization, the discourse surrounding it reached a point where the U.S. debated if a fetus should receive personhood (Zernike, 2024). Consequentially, the broadening of the rights of “unborn babies” (definition of the fetus according to the Louisiana Supreme Court cited in the NYT) limits those of pregnant women. This article aims to explore the working hypothesis that U.S. pro-life advocacy groups and media employed elements of a moral panic style in the period before the Supreme Court Dobbs hearing. The study analyzes the discourse of two right-wing advocacy agencies (Texas Right to Life and Texas Values) and one mainstream satellite media outlet (Fox News).
Social Capital Formation At Urban Level In Bangladesh: A Comparison Of Two City Corporation
Authors: Islam Md Nahidul 
Published: December 2024

Abstract
In a society that is becoming more urbanized, local governments are crucial to the welfare of the populace and the efficient provision of essential services. There is a consensus that strong metropolitan local governments are essential for generating sustained economic growth, improved public services, and the growth of social capital. The level of trust that residents have in their local government organizations is directly related to how satisfied they are with the services they receive. The purpose of the current study is to determine how satisfied Bangladeshi individuals are with city corporations, a type of urban local government entity. The goal of the study is to pinpoint the variables that may account for the variations in citizens’ satisfaction with the establishment of social capital in urban local government organizations. The study used a hybrid methodology based on survey results and key informant interviews (KII), in which 200 respondents from each of the two city corporations in the nation shared their thoughts. This study contributes by suggesting some fresh angles for a better understanding of Bangladeshi citizens’ levels of social capital formation toward city corporations.
A dynamic and decentralised headquarters to thrive in uncertainty
Authors: Blomvall Petteri , Hirvi Mikko 
Published: December 2024

Abstract
Military headquarters have been seen as grown up to the point that this reduces the agility of decision-making and decreases the survivability of the headquarters and command posts in war. At the same time, war is becoming ever more complex and intertwined through the fast pace of information flows and technological advancements. This design science research aims to solve these problems of headquarters. The research was done by framing the problem with several theories and then designing a solution. Systems thinking and complexity leadership theories were used to understand the problem. After this qualitative coding was used to form complexity leadership themes specific to military headquarters. These themes were combined with organisational theories and the military theories of tempo-based operations. A solution was then designed through theory-based analysis and abductive reasoning and tested in exercises. This article suggests that military headquarters should not seek for one optimal organisational structure, but instead the structures should be intentionally and dynamically tailored according to the situation and context at hand. A headquarters seen through the mental model of a Dynamic Headquarters Structure (DHS) can adjust its own networking, information-flows and delegation of decision-making to thrive in different environments.
Multiple occupational hazards, multiple occupational diseases - a study case
Authors: Mandanach Cristina , Angelescu Cristina , Handra Claudia Mariana 
Published: December 2024

Abstract
Industrial workers frequently have exposure to multiple hazards. Depending on the specific activity the intensity, duration and type of exposure may differ during the entire professional life, even in the same working place. These workers are at risk of developing several work-related disorders or even multiple occupational diseases. This study presents a case of a welder who performed heavy work (lifting and handling masselottes and metal casts) and was exposed to gases, fumes and vapors. He was diagnosed 8 years before with occupational lumbar discopathy and occupational pulmonary fibrosis (welders’ lung) based on symptoms and X-ray examination. He continued to work in the same workplace. At the current admission the respiratory symptoms (dyspnea on low exertion, wheezing, cough with seromucous sputum) were more severe and a large opacity of 5.3/4.3 cm slightly heterogeneous structure, with spiculated, iodophilic contour in lateral area of the subpleural segment of the upper right pulmonary lobe was found on the CT scan. This opacity was interpreted as probable lung cancer and the patient was sent for surgery.
The case illustrates the multiple health consequences of the working activities and the necessity to evaluate in a proper manner all possible hazards present in a certain working place.