bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia
Authors: Merke Deborah P , Mallappa Ashwini , Arlt Wiebke , Brac de la Perriere Aude , Lindén Hirschberg Angelica , Juul Anders , Newell-Price John , Perry Colin G , Prete Alessandro , Rees D Aled , Reisch Nicole , Stikkelbroeck Nike , Touraine Philippe , Maltby Kerry , Treasure F Peter , Porter John , Ross Richard J 
Published: February 2021

AbstractContextStandard glucocorticoid therapy in congenital adrenal hyperplasia (CAH) regularly fails to control androgen excess, causing glucocorticoid overexposure and poor health outcomes.ObjectiveWe investigated whether modified-release hydrocortisone (MR-HC), which mimics physiologic cortisol secretion, could improve disease control.MethodsA 6-month, randomized, phase 3 study was conducted of MR-HC vs standard glucocorticoid, followed by a single-arm MR-HC extension study. Primary outcomes were change in 24-hour SD score (SDS) of androgen precursor 17-hydroxyprogesterone (17OHP) for phase 3, and efficacy, safety and tolerability of MR-HC for the extension study.ResultsThe phase 3 study recruited 122 adult CAH patients. Although the study failed its primary outcome at 6 months, there was evidence of better biochemical control on MR-HC, with lower 17OHP SDS at 4 (P = .007) and 12 (P = .019) weeks, and between 07:00h to 15:00h (P = .044) at 6 months. The percentage of patients with controlled 09:00h serum 17OHP (&lt; 1200 ng/dL) was 52% at baseline, at 6 months 91% for MR-HC and 71% for standard therapy (P = .002), and 80% for MR-HC at 18 months’ extension. The median daily hydrocortisone dose was 25 mg at baseline, at 6 months 31 mg for standard therapy, and 30 mg for MR-HC, and after 18 months 20 mg MR-HC. Three adrenal crises occurred in phase 3, none on MR-HC and 4 in the extension study. MR-HC resulted in patient-reported benefit including menses restoration in 8 patients (1 on standard therapy), and 3 patient and 4 partner pregnancies (none on standard therapy).ConclusionMR-HC improved biochemical disease control in adults with reduction in steroid dose over time and patient-reported benefit.
Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly
Authors: Kuker Adriana P , Shen Wei , Jin Zhezhen , Singh Simran , Chen Jun , Bruce Jeffrey N , Freda Pamela U 
Published: February 2021

Abstract

Context
In active acromegaly, the lipolytic and insulin antagonistic effects of growth hormone (GH) excess alter adipose tissue (AT) deposition, reduce body fat, and increase insulin resistance. This pattern reverses with surgical therapy. Pegvisomant treats acromegaly by blocking GH receptor (GHR) signal transduction and lowering insulin-like growth factor 1 (IGF-1) levels. The long-term effects of GHR antagonist treatment of acromegaly on body composition have not been studied.

Methods
We prospectively studied 21 patients with active acromegaly who were starting pegvisomant. Body composition was examined by whole body magnetic resonance imaging, proton magnetic resonance spectroscopy of liver and muscle and dual-energy x-ray absorptiometry, and endocrine and metabolic markers were measured before and serially during 1.0 to 13.4 years of pegvisomant therapy. The data of patients with acromegaly were compared with predicted and to matched controls.

Results
Mass of visceral AT (VAT) increased to a peak of 187% (1.56-229%) (P &lt; .001) and subcutaneous AT (SAT) to 109% (–17% to 57%) (P = .04) of baseline. These remained persistently and stably increased, but did not differ from predicted during long-term pegvisomant therapy. Intrahepatic lipid rose from 1.75% to 3.04 % (P = .04). Although lean tissue mass decreased significantly, skeletal muscle (SM) did not change. IGF-1 levels normalized, and homeostasis model assessment insulin resistance and HbA1C were lowered.

Conclusion
Long-term pegvisomant therapy is accompanied by increases in VAT and SAT mass that do not differ from predicted, stable SM mass and improvements in glucose metabolism. Long-term pegvisomant therapy does not produce a GH deficiency-like pattern of body composition change.
Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome
Authors: Andrisse Stanley , Garcia-Reyes Yesenia , Pyle Laura , Kelsey Megan M , Nadeau Kristen J , Cree-Green Melanie 
Published: February 2021

Abstract

Context
Polycystic ovary syndrome (PCOS) is common and associated with metabolic syndrome. In the general population, metabolic disease varies by race and ethnicity.

Objective
This work aimed to examine in depth the interaction of race and ethnicity with PCOS-related metabolic disease in adolescent youth.

Methods
A secondary analysis was conducted of data from girls (age 12-21 years) with overweight or obesity (&gt; 90 body mass index [BMI] percentile) and PCOS. Measurements included fasting hormone and metabolic measures, a 2-hour oral glucose tolerance test (OGTT), and magnetic resonance imaging for hepatic fat. Groups were categorized by race or ethnicity.

Results
Participants included 39 non-Hispanic White (NHW, age 15.7 ± 0.2 years; BMI 97.7 ± 0.2 percentile), 50 Hispanic (HW, 15.2 ± 0.3 years; 97.9 ± 0.3 percentile), and 12 non-Hispanic Black (NHB, 16.0 ± 0.6 years; 98.6 ± 0.4 percentile) adolescents. Hepatic markers of insulin resistance were worse in NHW, including lower sex hormone–binding globulin and higher triglycerides over high-density lipoprotein cholesterol (TGs/HDL-C) ratio (P = .002 overall, HW vs NHB [P = .009] vs NHW [P = 0.020]), although homeostasis model assessment of estimated insulin resistance was worst in NHB (P = .010 overall, NHW vs NHB P = .014). Fasting and 2-hour OGTT glucose were not different between groups, although glycated hemoglobin A1c (HbA1c) was lowest in NHW (overall P &lt; .001, NHW 5.2 ± 0.3 vs HW 5.5 ± 0.3 P &lt; .001 vs 5.7 ± 0.4%, P &lt; .001). The frequency of hepatic steatosis (HW 62%, NHW 42%, NHB 25%, P = .032); low HDL-C &lt; 40 mg/dL (HW 82%, NHW 61%, NHB 50%, P &lt; .001) and prediabetes HbA1c 5.7% to 6.4% (NHB 50%, HW 36%, NHW 5%, P &lt; .001) were different between the groups.

Conclusion
Adolescents with PCOS appear to show similar racial and ethnic variation to the general population in terms of metabolic disease components.
The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons
Authors: Sonnenberg Simon Bennet , Rauer Jonah , Göhr Christoph , Gorinski Nataliya , Schade Sophie Kristin , Abdel Galil Dalia , Naumenko Vladimir , Zeug André , Bischoff Stephan C. , Ponimaskin Evgeni , Guseva Daria 
Published: February 2021

ABSTRACT
Morphological remodeling of dendritic spines is critically involved in memory formation and depends on adhesion molecules. Serotonin receptors are also implicated in this remodeling, though the underlying mechanisms remain enigmatic. Here, we uncovered a signaling pathway involving the adhesion molecule L1CAM (L1) and serotonin receptor 5-HT4 (5-HT4R, encoded by HTR4). Using Förster resonance energy transfer (FRET) imaging, we demonstrated a physical interaction between 5-HT4R and L1, and found that 5-HT4R–L1 heterodimerization facilitates mitogen-activated protein kinase activation in a Gs-dependent manner. We also found that 5-HT4R–L1-mediated signaling is involved in G13-dependent modulation of cofilin-1 activity. In hippocampal neurons in vitro, the 5-HT4R–L1 pathway triggers maturation of dendritic spines. Thus, the 5-HT4R–L1 signaling module represents a previously unknown molecular pathway regulating synaptic remodeling.
Effect of density and species preferences on collective choices: an experimental study on maggot aggregation behaviours
Authors: Fouche Quentin , Hedouin Valery , Charabidze Damien 
Published: February 2021

ABSTRACTCollective decisions have been extensively studied in arthropods, but they remain poorly understood in heterospecific groups. This study was designed to (1) assess the collective behaviours of blow fly larvae (Diptera: Calliphoridae) in groups varying in density and species composition, and (2) relate them to the costs and benefits of aggregating on fresh or decomposed food. First, experiments testing conspecific groups of Lucilia sericata and Calliphora vicina larvae, two species feeding at the same time on fresh carcasses, demonstrated decreases in growth and survival on rotten beef liver compared with fresh liver. However, mixing species together reduced this adverse impact of decomposition by increasing the mass of emerged adults. Second, larval groups were observed in binary choice tests between fresh and rotten liver (i.e. optimal and sub-optimal food sources). The results showed that larvae interacted with each other and that these interactions influenced their food preferences. We observed that (1) larvae were able to collectively choose the optimal food, (2) their choice accuracy increased with larval density and (3) the presence of another species induced a reversal in larval preference towards rotten food. These results highlight the ubiquity of collective decision properties in gregarious insects. They also reveal an unexpected effect of interspecific association, suggesting the colonization of new resources through a developmental niche construction.
Feel the light: sight-independent negative phototactic response in octopus arms
Authors: Katz Itamar , Shomrat Tal , Nesher Nir 
Published: February 2021

ABSTRACT
Controlling the octopus's flexible hyper-redundant body is a challenging task. It is assumed that the octopus has poor proprioception which has driven the development of unique mechanisms for efficient body control. Here we report on such a mechanism: a phototactic response of extraocular photoreception. Extraocular photoreception has been observed in many and diverse species. Previous research on cephalopods revealed that increased illumination on their skin evokes chromatophore expansion. Recently, the mechanism was investigated and has been termed ‘light-activated chromatophore expansion’ (LACE). In this work we show that in response to illumination, the arm tip reacts in a reflex-like manner, folding in and moving away from the light beam. We performed a set of behavioral experiments and surgical manipulations to elucidate and characterize this phototactic response. We found that in contrast to the local activation and control of LACE, the phototactic response is mediated by the brain, although it is expressed in a reflex-like pattern. Our research results and observations led us to propose that the phototaxis is a means for protecting the arms in an instinctive manner from potential daytime predators such as fish and crabs, that could identify the worm-like tips as food. Indeed, observations of the octopuses revealed that their arm tips are folded in during the daytime, whereas at night they are extended. Thus, the phototactic response might compensate for the octopus's poor proprioception by keeping their arms folded in illuminated areas, without the need to be aware of their state.
Parent-child signals identify candidate cancer driver genes
Authors: Ramsahai Emilie Ann , Tripathi Vrijesh , John Melford 
Published: February 2021

Background: The DREAM Challenge evaluated methods to identify molecular pathways facilitating the detection of multiple genes affecting critical interactions and processes. Dysregulation of pathways by well-known driver genes is often found in the development and progression of cancer. We used the gene interaction networks provided and the scoring rounds to test disease module identification methods to nominate candidate driver genes in these modules. Method: Our algorithm calculated the proportion of the whole network accessible in two steps from each node in a combined network, which was defined as a 2-reach gene value. Genes with high 2-reach values were used to form the center of star cover clusters. These clusters were assessed for significant modules. Within these modules we identified novel candidate driver genes, by considering the parent-child relationship of well-known driver genes. Disturbance to such driver genes or their upstream parents, can lead to disruption of highly regulated signals affecting the normal functions of cells. We explored these parents as a potential source for candidate driver genes. Results: An initial list of 57 candidate driver genes was identified from 13 significant modules. Analysis of the parent-child relationships of well-known driver genes in these modules prioritized PRKDC, YWHAB, GSK3B, and PPP1CB. Conclusion: Our method incorporated the simple m-reach topology metric in disease module identification and its relationship with known driver genes to identify candidate genes. The four genes shortlisted have been highlighted in recent publications in the literature, which supports the need for further wet lab experimental investigation.
Monetary value of disability-adjusted life years lost from all causes in Mauritius in 2019
Authors: Musango Laurent , Nundoochan Ajoy , Van Wilder Philippe , Kirigia Joses Muthuri 
Published: February 2021

Background: The Republic of Mauritius had a total of 422,567 disability-adjusted life years (DALYs) from all causes in 2019. This study aimed to estimate the monetary value of DALYs lost in 2019 from all causes in Mauritius and those projected to be lost in 2030; and to estimate the monetary value of DALYs savings in 2030 if Mauritius were to attain the national targets related to five targets of the United Nations Sustainable Development Goal 3 on good health and well-being. Methods: The human capital approach was used to monetarily value DALYs lost from 157 causes in 2019. The monetary value of DALYs lost in 2019 from each cause was calculated from the product of net gross domestic product (GDP) per capita in Mauritius and the number of DALYs lost from a specific cause. The percentage reductions implied in the SDG3 targets were used to project the monetary values of DALYs expected in 2030. The potential savings equal the monetary value of DALYs lost in 2019 less the monetary value of DALYs expected in 2030. Results: The DALYs lost in 2019 had a total monetary value of Int$ 9.46 billion and a mean value of Int$ 22,389 per DALY. Of this amount, 84.2% resulted from non-communicable diseases; 8.7% from communicable, maternal, neonatal, and nutritional diseases; and 7.1% from injuries. Full attainment of national targets related to the five SDG3 targets would avert DALYs losses to the value of Int$ 2.4 billion. Conclusions: Diseases and injuries cause a significant annual DALYs loss with substantive monetary value. Fully achieving the five SDG3 targets could save Mauritius nearly 8% of its total GDP in 2019. To achieve such savings, Mauritius needs to strengthen further the national health system, other systems that tackle the social determinants of health, and the national health research system.
Pooled testing conserves SARS-CoV-2 laboratory resources and improves test turn-around time: experience on the Kenyan Coast
Authors: Agoti Charles N. , Mutunga Martin , Lambisia Arnold W. , Kimani Domtila , Cheruiyot Robinson , Kiyuka Patience , Lewa Clement , Gicheru Elijah , Tendwa Metrine , Said Mohammed Khadija , Osoti Victor , Makale Johnstone , Tawa Brian , Odundo Calleb , Cheruiyot Wesley , Nyamu Wilfred , Gumbi Wilson , Mwacharo Jedidah , Nyamako Lydia , Otieno Edward , Amadi David , Thoya Janet , Karani Angela , Mugo Daisy , Musyoki Jennifer , Gumba Horace , Mwarumba Salim , M. Gichuki Bonface , Njuguna Susan , Riako Debra , Mutua Shadrack , Gitonga John N. , Sein Yiakon , Bartilol Brian , Mwangi Shaban J. , O. Omuoyo Donwilliams , M. Morobe John , de Laurent Zaydah R. , Bejon Philip , Ochola-Oyier Lynette Isabella , Tsofa Benjamin 
Published: February 2021

Background. International recommendations for the control of the coronavirus disease 2019 (COVID-19) pandemic emphasize the central role of laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent, at scale. The availability of testing reagents, laboratory equipment and qualified staff are important bottlenecks to achieving this. Elsewhere, pooled testing (i.e. combining multiple samples in the same reaction) has been suggested to increase testing capacities in the pandemic period. Methods. We discuss our experience with SARS-CoV-2 pooled testing using real-time reverse transcription polymerase chain reaction (RT-PCR) on the Kenyan Coast. Results. In mid-May, 2020, our RT-PCR testing capacity for SARS-CoV-2 was improved by ~100% as a result of adoption of a six-sample pooled testing strategy. This was accompanied with a concomitant saving of ~50% of SARS-CoV-2 laboratory test kits at both the RNA extraction and RT-PCR stages. However, pooled testing came with a slight decline of test sensitivity. The RT-PCR cycle threshold value (ΔCt) was ~1.59 higher for samples tested in pools compared to samples tested singly. Conclusions. Pooled testing is a useful strategy to increase SARS-CoV-2 laboratory testing capacity especially in low-income settings.
Noun phrase in Enets
Authors: Shluinsky Andrey 
Published: February 2021

The paper presents a corpus-based description of the noun phrase structure in Enets dealing with both Enets dialects – Forest Enets and Tundra Enets. An Enets noun phrase has six slots for modifiers: determiner, relative clause, possessor NP, numeral, adjective phrase, apposed NP. Determiners, relative clauses, and adjective phrases are subject to linear recursion, other modifiers are not. All modifiers precede the head NP. In Enets, there is no agreement between head noun and modifiers, but numerals have different patterns in the choice of head noun number form.
Kokkuvõte. Andrej Šluinski: Noomenifraas eenetsi keeles. Artikkel esitab korpuspõhise kirjelduse eenetsi keele noomenifraasi struktuurist mõlemas eenetsi keele murdes – metsaeenetsi ja tundraeenetsi. Eenetsi noomenifraasil on kuus täiendikohta: määratleja, relatiivlause, omajat väljendav NP, numeraal, omadussõnafraas, appositsiooniline NP. Määratlejad, relatiivlaused ja omadussõnafraasid alluvad lineaarsele rekursioonile, teised täiendid mitte. Kõik täiendid eelnevad põhisõnale. Eenetsi keeles puudub põhisõna ja täiendi ühilduvus, kui numeraalid nõuavad noomenifraasi põhisõnalt erinevaid arvuvorme.
Аннотация. Андрей Шлуинский: Именная группа в энецком языке. В статье представлено выполненное на материале корпуса текстов описание структуры именной группы в обоих диалектах энецкого языка – лесном тундровом. Энецкая именная группа содержит шесть позиций для модификаторов вершинного существительного: детерминатор, относительное предложение, именная группа посессора, числительное, группа прилагательного, соположенная именная группа. Детерминаторы, относительные предложения и группы прилагательного подлежат линейной рекурсии, в отличие от других модификаторов. Все модификаторы предшествуют вершинному существительному. В энецком языке отсутствует согласование между вершинным существительным и модификаторами, но представлены разные модели выбора числовой формы вершинного существительного в именных группах с числительными.
ɛ-Strong Simulation of Fractional Brownian Motion and Related Stochastic Differential Equations
Authors: Chen Yi , Dong Jing , Ni Hao 
Published: February 2021

Consider a fractional Brownian motion (fBM) [Formula: see text] with Hurst index [Formula: see text]. We construct a probability space supporting both B H and a fully simulatable process [Formula: see text] such that[Formula: see text] with probability one for any user-specified error bound [Formula: see text]. When [Formula: see text], we further enhance our error guarantee to the α-Hölder norm for any [Formula: see text]. This enables us to extend our algorithm to the simulation of fBM-driven stochastic differential equations [Formula: see text]. Under mild regularity conditions on the drift and diffusion coefficients of Y, we construct a probability space supporting both Y and a fully simulatable process [Formula: see text] such that[Formula: see text] with probability one. Our algorithms enjoy the tolerance-enforcement feature, under which the error bounds can be updated sequentially in an efficient way. Thus, the algorithms can be readily combined with other advanced simulation techniques to estimate the expectations of functionals of fBMs efficiently.
Apple Fruit Recognition Based on a Deep Learning Algorithm Using an Improved Lightweight Network
Authors: Ji Jiangtao , Zhu Xu , Ma Hao , Wang Hui , Jin Xin , Zhao Kaixuan 
Published: February 2021

HIGHLIGHTSA deep learning algorithm with an improved lightweight network was used to identify apple fruit.Multiscale pooling was used to reduce the image size and enrich the features.Compound scaling was used to scale the basic network.The optimal compound scaling coefficient for apple identification was obtained with the WOA algorithm.The proposed method achieved an average recognition precision rate of 94.43% and a speed of 0.051s.ABSTRACT. Accurate fruit identification is the basis for automating the operation of orchard production. To better apply the identification model in mobile devices so that venue becomes a less restrictive factor for application, this study proposes an apple fruit identification method based on an improved lightweight network named “MobileNetV3-Small.” The whale optimization algorithm was introduced to improve the model by obtaining an optimal compound-scaling coefficient for the MobileNetV3-Small network. A multiscale pooling approach was used for fruit recognition, comprising operations such as lossless scaling and feature extraction on sample images. The obtained images were then inputted into the model for recognition and classification. The experimental process was conducted on an apple data set. The test results show that the multiclass average precision of apple recognition using this model was 94.43% and the running time of recognition was 0.051 s per image. Both indicators outperformed the control network models of “MobileNetV3-Small,” ResNet-50, and VGG-19. This model is 14.63% more accurate and 1.95 times quicker on average in identification than the next best model. These findings indicate that the method can realize high-efficiency and high-precision recognition of apples with high stability and portability, which lays a good foundation for the mechanization of repetitive operations such as orchard yield estimation, fruit labeling, and fruit picking. Keywords: Apple recognition, Compound scaling, Deep learning algorithm, Lightweight network, Yield estimation.
Rapid and label free detection of aflatoxin B1 in alcoholic beverages with a microfluid fiber device
Authors: Chen Huifang , Han Fei , Mao Bangning , Gu Ju , Li Yudi , Zhao Chunliu , Wang Yi , Wang Dongning , Zhan Jing 
Published: February 2021

A rapid and label free aflatoxin

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) microfluid sensor was proposed and tested. The device was fabricated with hollow-core photonics crystal fiber infiltrated with the

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solution. The autofluorescence emitting from the

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molecules was detected. The sensor length was optimized. The

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concentration was tested with a 4 cm long sensor. The best limit of detection was achieved as low as 1.34 ng/ml, which meets the test requirement of the national standards for

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in food. The effectiveness of this sensor being applied in beer solution was also verified to be a little more sensitive than in aqueous solution. Compared with traditional

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detection methods, the proposed single-ended device perfectly satisfies the demand of process control in alcoholic beverages manufacture.