bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Expression of miR-146a-5p and Bcl-2 in Oncocytic Carcinoma of the Breast: A Case Report
Authors: Koi Yumiko , Yamamoto Yuki , Fukunaga Saori , Sasada Tatsunari , Kajitani Keiko , Ohara Masahiro , Daimaru Yutaka , Tahara Hidetoshi , Tamada Ryuichiro 
Published: June 2021

Abstract
Background: Oncocytic carcinoma of the breast is extremely rare, and its molecular profile is poorly understood. The distinctive feature of oncocytic carcinoma of the breast is that the granular eosinophilic cytoplasm contains numerous mitochondria. Recently, microRNA-146a-5p has been identified as a contributor to carcinogenesis and as a mitochondria-related microRNA, which regulates the mitochondrial function affecting Bcl-2. Bcl-2 plays a role in mitochondrial apoptosis.Case presentation: We report the clinical features, histopathological features, and immunohistochemical and molecular findings of oncocytic carcinoma of the breast in a 76-year-old woman. Immunohistochemistry studies revealed that the tumor cells were positive for antimitochondrial antibody but negative for gross cystic disease fluid protein 15, which confirmed the diagnosis. For molecular profiling, expression of microRNA-146a-5p and Bcl-2 messenger RNA (mRNA), which are mitochondria-related small molecules, were evaluated using real-time reverse transcription polymerase chain reaction. We found that the expression of microRNA-146a-5p was significantly lower (p < 0.01) and that of Bcl-2 mRNA was significantly higher (p < 0.01) compared to the control group (with no specific type of breast cancer). Conclusions: The significant changes in the expression of microRNA-146a-5p and Bcl-2 are specific to oncocytic carcinoma of the breast. Therefore, we suggest that the use of microRNA-146a-5p to target Bcl-2 has a potential therapeutic effect on oncocytic carcinoma of the breast.
The Generalized Hamilton Principle and Non-Hermitian Quantum Theory
Authors: Wu Xiang-Yao , Wu Ben-Shan , Liu Xiao-Jing , Ren Ming-Li , Han Meng , Jiang Ming-Qi , Zhu Xiang-Jiu , Liu Han , Wu Qi-Ming 
Published: June 2021

Abstract
The Hamilton principle is a variation principle describing the isolated and conservative systems, its Lagrange function is the difference between kinetic energy and potential energy. By Feynman path integration, we can obtain the Hermitian quantum theory, i.e., the standard Schrodinger equation. In this paper, we have generalized the Hamilton principle to the generalized Hamilton principle, which can describe the open system (mass or energy exchange systems) and nonconservative force systems or dissipative systems, and given the generalized Lagrange function, it has to do with the kinetic energy, potential energy and the work of nonconservative forces to do. With the Feynman path integration, we have given the non-Hermitian quantum theory of the nonconservative force systems. Otherwise, with the generalized Hamilton principle, we have given the generalized Hamiltonian for the particle exchanging heat with the outside world, which is the sum of kinetic energy, potential energy and thermal energy, and further given the equation of quantum thermodynamics. PACS: 03.65.-w, 05.70.Ce, 05.30.Rt
Technical Study of Polychrome Arhat Figures Dated From the Song Dynasty(960-1279 CE) From the Lingyan Temple, Changqing, Shandong, China
Authors: Tong Yongdong , Cai Youzhen , Wang Xuening , Li Zhimin , Nevin Austin , Ma Qinglin 
Published: June 2021

Abstract
Scientific analysis revealed the materials and techniques used in the process of making the polychrome sculptures providing a solid foundation for the protection and restoration of the painted statues. In addition analysis revealed changes in colour schemes applied to the sculptures can provide the basis for the virtual restoration of the painted statues. In order carry out scientifically-informed protection and restoration of the Bodhidharma statue from the Lingyan Temple, Changqinq, Shandong, several analytical methods such as optical microscope (OM), Micro-Raman spectroscopy (μ-RS), scanning electron microscopy coupled with energy dispersive X-ray analysis (SEM-EDS) and Fourier transform infrared spectroscopy (FTIR) were employed. Analysis clearly reveal the information including the stratigraphic structure and the composition of pigment. The use of silver foils and golden yellow pyrophyllite mineral to replace gold foils were found in the gilding paint layer in the later repainting after the Song Dynasty. This work reports the coexistence of emerald green (Cu(C2H3O2)2·3Cu(AsO2)2) and the degradation product lavendulan (NaCaCu5(AsO4)4Cl·5H2O) in large areas of the paint stratigraphy and on the surface confirming that the degradation of emerald green is related to the thickness of the paint layer; in thinner paint layers emerald green is transformed in lavendulan, while thicker layers of contain both lavendulan and emerald green, suggesting an environmental source of chlorides.
Magnitude and determinants of Poor Self-Care Practices and associated factors among Hypertensive Patients attending at Debre Berhan Referral Hospital, Amhara Regional State, Ethiopia
Authors: Getnet Mekasha 
Published: June 2021

Abstract
Background: Hypertension is one of a non-communicable diseases that become public health concern and cause early mortality around the globe. Poor management of hypertension is a very important cause for various cardiovascular problems. Reducing the outcome of the disease through compliance to self-care practices is crucial. However, comprehensive assessment on domains of self-care was not well studied.
Objective: To assess self-care practices and associated factors among hypertensive patient attending in Debre Berhan Referral Hospital.
Method: A hospital based cross-sectional study was conducted. Initially the data were checked manually and entered in to Epi-Data version 3.1. P-value of <0.05 was used as a cut of point to affirm statistical significance. Finally, results were presented in text, tables and graphs.
Result: The prevalence of poor self-care practice was had poor self-care practices with 95% CI (71.7, 80.3%). Multivariate analysis indicated that patients without comorbidities 1.5 (1.3-1.9), being aged 60 and above years 4.2 (1.7-10.3) and unavailability of blood pressure apparatus at home were more likely to have poor self-care practice as compared with their counter parts.
Conclusion: - The level of self-care practice was found to be low and attention is needed for self-care practices.
Depression, Anxiety and Stress in Women with Breech Pregnancy - "Be not Afraid": A Prospective Study
Authors: Schauer Madeleine , Latartara Elisabetta , Alonso-Espias Maria , Rossetti Emma , Gebert Pimrapat , Henrich Wolfgang , Hinkson Larry 
Published: June 2021

Abstract
Background: Breech presentation at term is associated with higher perinatal complications through the increased incidence of cesarean section and complications by vaginal breech birth. The decision-making process between breech delivery, trial of external cephalic version or cesarean section may lead to maternal depression, stress and anxiety. Mental disorder in itself is associated with poorer maternal and fetal outcomes, such as preterm birth, small for gestational age infants, lower birth weight and increased risk for postnatal depression. This study aims to evaluate the level of psychological distress for women with breech presentation compared to cephalic presentation. We hypothesized, that women with breech presentation have higher levels of depression, stress and anxiety than other pregnant women. Secondary objectives were to analyze potential demographic risk factors and comorbidity of psychological distress in breech pregnancy. Methods: The breech study group was formed by 379 women with breech presentation. A sample of 128 women with cephalic presentation was recruited during routine clinical care. Depression, anxiety and stress symptoms were ascertained by means of the Depression-Anxiety-Stress-Score (DASS)-21 questionnaire. Categorial data was analyzed with Chi-square or exact test, continuous data with unpaired t-test or Mann-Whitney-U-test. Demographic risk factors were identified using a binary logistic regression model.Results: Prevalence of psychological distress among women with breech was not higher compared to those of other pregnant women. Symptomatic depression, anxiety and stress affected 5.8%, 14.5% and 11.9% of women with breech, respectively. Decreasing age was identified as a risk factor for anxiety (p = 0.006). Multiparity increased risk for depression (p = 0.001), for anxiety (p = 0.026) and for perinatal stress (p = 0.010). More than 80% of women with depressive symptoms had comorbidities of psychological distress.Conclusions: Breech presentation compared to cephalic presentation was not associated with higher levels of psychological distress. However, breech pregnancies are affected by symptoms of potential mental disorder. Multiparous women and younger women may need additional support and would benefit from a standardized screening tool for the assessment of perinatal psychological distress.Clinical Trial Registration: Ethical approval (EA2/241/18) was granted by the Ethics Commission of the Charité University Hospital on the 23.01.2019 (ClinicalTrials.gov Identifier: NCT03827226)
Glucagon-like Peptide-1 Receptor Agonists and Cardioprotective Benefit in Patients With Type 2 Diabetes Without Baseline Metformin: An Update Meta-analysis
Authors: Cobo Augusto Lavalle , Masson Walter , Lobo Martin , Masson Gerardo , Molinero Graciela 
Published: June 2021

Abstract
Background: Sodium Glucose Co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) were associated with a reduction in cardiovascular events in cardiovascular outcomes trials (CVOTs) in type 2 diabetes. Most of the patients included in these trials received metformin as background therapy. The purpose of this study was to evaluate the effect of glucagon-like peptide-1 receptor agonists on major cardiovascular events (MACE) in metformin-naïve patients with type 2 diabetes.Methods: A meta-analysis was performed of randomized controlled clinical trials of GLP-1RAs on type 2 diabetes populations, after searching the PubMed/MEDLINE, Embase, Scielo, Google Scholar and Cochrane Controlled Trials databases. The primary endpoint was MACE. The secondary endpoints were cardiovascular death and all-cause mortality. A meta-analysis of time-to-event outcomes was performed.Results: Six eligible trials, including 10419 patients, were identified and considered eligible for the analyses. GLP-1RAs were associated with a significant reduction in MACE incidence (HR: 0.87, 95% confidence interval: 0.80–0.94; I2:0%). The analysis of the secondary endpoints showed a non-significant reduction in all-cause mortality (HR: 0.86, 95% confidence interval: 0.73-1.00 I2:0%) and cardiovascular mortality (HR: 0.81, 95% confidence interval: 0.63–1.05; I2:0%). Conclusions: In this meta-analysis, GLP-1RAs reduced the incidence of MACE in patients with type 2 diabetes without metformin at baseline, without significant reduction in all-cause mortality and cardiovascular mortality. These results support the fact that benefit in cardiovascular outcomes is independent of metformin use when GLP-1Ras are administered.
Synthesis of Polymer-based ZnO/TiO2 NCs Flexible Sheets as High Dielectric Materials
Authors: Kanwal N. , Pervaiz S. , Rasheed A. , Saleem M. , Khan Ijaz Ahmad 
Published: June 2021

Abstract
Polymer-based ZnO/TiO2 NCs flexible sheets with high dielectric permittivity and low loss factor have numerous applications in light emitting and energy storage devices. In this work, polymer-based ZnO/TiO2 NCs are synthesized by co-precipitation technique. The development of various diffraction planes (X-rays diffraction analysis) related to TiO2 and ZnO phases confirms the synthesis of polycrystalline polymer-based ZnO/TiO2 NCs. The crystallinity of various phases is associated with increasing ZnO nanofillers. The surface morphology (scanning electron microscopic analysis) comprising of nanoparticles of different shapes is associated with increasing amount of nanofillers. The EDX analysis confirms the presence of Zn, O and Ti in the synthesized polymer-based ZnO/TiO2 NCs. Dielectric measurements demonstrating the sharp increase in dielectric permittivity with relatively low dissipation factor of synthesized polymer-based ZnO/TiO2 NCs are associated with increasing amount of ZnO nanofillers. The static value of dielectric constant (e’) at low frequency (100 Hz) is found to be 14.56 for sample having 10% ZnO nanofillers that is 2.11 times greater than pure PVDF and it shows relatively low value of dissipation factor. The observed σac of synthesized polymer-based ZnO/TiO2 NCs at 3.0×105 Hz and 1.0×106 Hz are ranged from 3.75-9.79 and 15.61-42.72 mS/m respectively. The decreasing complex impedance and increasing electric modulus further confirm that the synthesized polymer-based ZnO/TiO2 NCs flexible sheets are the promising candidate for better capacitive performance showing high strength and flexibility.
Multivariate Optimization of Removing of Cobalt(II) with an Efficient Aminated-GMA Polypropylene Adsorbent by Induced-Grafted Polymerization under Simultaneous Gamma-Ray Irradiation
Authors: Maleki Fatemeh , Gholami Mobina , Torkaman Rezvan , Torab-Mostaedi Meisam , Asadollahzadeh Mehdi 
Published: June 2021

Abstract
Nowadays, radiation grafting polymer adsorbents have been widely developed due to their advantages, such as low operating cost, high efficiency. In this research, glycidyl methacrylate monomers by simultaneous irradiation of gamma-ray with a dose of 20 kGy were grafted on polypropylene polymer fibers. The grafted polymer was then modified using different amino groups and tested for adsorption of cobalt ions in an aqueous solution. Finally, modified polymer adsorbent with the high efficiency for cobalt ions adsorption was synthesized and tested for further investigation. Different modes of cobalt ions adsorption were tested in other adsorption conditions, including adsorption contact time, pH, different amounts of adsorbent mass, and different concentrations of cobalt ions solution. The adsorbent structure was characterized with FT-IR, and SEM techniques and illustrated having an efficient grafting percentage and adsorption capability for cobalt removing by batch experiments. The optimum conditions were obtained by a central composite design as follows: adsorbent mass = 0.07 g, initial concentration = 40 mg/L, time = 182 min, and pH = 4.5 with ethylenediamine as a modified monomer and high amination percentage. The features such as inexpensive adsorbent, easy to prepare, high efficiency, and stability allow the radiated-induced grafted adsorbent to constitute one of promising materials for heavy metals remediation.
New UV Curable Acrylated Urethane-Oligoesters Derived From Poly(Ethylene Terephthalate) PET Waste
Authors: Khedr Medhat S. Farahat 
Published: June 2021

Abstract
The glycolysis products of polyethylene terephthalate (PET) waste represent a potential source for many value-added products that contain terephthalate repeating units in their backbones. Terephthalate repeating units were not attained directly from terephthalic acid due to its high melting point in addition to its tendency to sublime before it reacts. Glycolysis of PET provides an excellent solution for recycling polymer waste and constitutes a substantial starting material for manufacturing materials with high mechanical stress, such as unsaturated polyesters and polyurethane products. In this study, PET was first depolymerized by glycolysis, and glycolyzed products were then dimerized by reaction with toluene di-isocyanate TDI with half equivalence of their hydroxyl groups for the purpose of inserting urethane blocks into the oligomer structure. The remaining half equivalence of terminal hydroxyl groups was modified into acrylate groups by an acrylation reaction. The acrylated oligo urethane ester products were crosslinked with different co-monomers and tested for UV curability and mechanical properties, and they showed outstanding results.
ASSESSMENT OF THE EFFECT OF BORON NEUTRON CAPTURE THERAPY ON TUMOR CELL LINES AND PRIMARY EMBRYONIC CELL CULTURE
Authors: Kanygin V. V. , Kasatova A. I. , Razumov I. A. , Zavyalov E. L. , Kichigin A. I. , Mukhamadiyarov R. A. , Taskaev S. Yu. 
Published: June 2021

Introduction. Boron neutron capture therapy (bnct) is a promising method for treating tumors, in particular, infiltrative malignant tumors, due to the selective destruction of tumor cells without damaging the surrounding normal tissues. This type of therapy is based on nuclear reaction of neutron capture by stable 10b isotope. For the successful implementation of bnct, boron delivery drugs that must be selectively accumulated in malignant cells in a sufficient amount, and a neutron source with the energy required for the neutron capture reaction are needed. At the budker institute of nuclear physics, the accelerator-based neutron source was designed with flux parameters allowing studies on bnct to be conducted.Objective: to assess the effect of bnct on tumor and normal cell lines using borphenylalanine (bpa), borcaptate (bsh) and liposomal borcaptat as boron delivery drugs.Materials and methods. Human cell cultures: glioblastoma (u87), colorectal human adenocarcinoma (sw-620), human melanoma (sk-mel28) and primary embryonic cell lines were irradiated with a neutron flux at the presence of bpa, bsh and liposomal bsh with a concentration of 10b 40 μg/ml. The short-term cytotoxic effect of irradiation was evaluated using trypan blue. Cell survival 96 hours after irradiation was determined using mtt test, and survival fraction was evaluated using the clonogenic test.Results. Early cytotoxic effects of irradiation were not observed for all 4 cell lines. According to mtt and clonogenic tests, the most pronounced effect of bnct was noticed for sw-620 and u87 lines, regardless of boron delivery drug used. For sk-mel28 line, the best effect was achieved after irradiation with liposomal borocaptate. For the primary transplanted embryonic line, high toxicity was revealed when bnct was performed with borphenylalanine and borcaptate.Conclusion. The data obtained indicate that the accelerator-based bnct using boron delivery drugs, such as borphenylalanine, borcaptate and liposomal borcaptat, has a positive effect on tumor lines of glioblastoma, colorectal adenocarcinoma and melanoma.
INFLUENCE OF CHRONIC NEUROGENIC PAIN ON THE DYNAMICS OF THE NO-SYSTEM FUNCTIONING DURING MELANOMA B16/F10 GROWTH IN MALE MICE
Authors: Kit O. I. , Kotieva I. M. , Frantsiyants E. M. , Surikova E. I. , Kaplieva I. V. , Bandovkina V. A. , Trepitaki L. K. , Neskubina I. V. , Pogorelova Ju. A. 
Published: June 2021

Since B16/F10 melanoma demonstrated gender differences in its growth in the presence of chronic neuropathic pain (cnp) and changes in the system of proangiogenic growth factors, the aim of the study was to analyze levels of components of the no-system in male mice during the growth of transplantable B16/F10 melanoma in the presence of cnp.Material and Methods. 66 male mice С57Вl/6 were used in the experiment. A model of subcutaneous growth of B16/F10 melanoma (during 3 weeks) was created in the cnp presence (sciatic nerve ligation). Concentrations of nos-2, nos-3, l-arginine, citrulline, total nitrite, nitrotyrosine and adma were determined by elisa in intact and tumor tissues.Results. A significant increase in levels of no-synthases was revealed in the skin and tumor tissues in the tumor growth with cnp from week 1, as well as a decrease in the level of total nitrite in the skin, multidirectional dynamics of adma and arginine levels, a steadily increased level of citrulline in the skin and tumor in the dynamics of tumor growth with cnp.Conclusions. Male mice with B16 melanoma growing in the presence of cnp demonstrated a more active functioning of the no-system already from week 1, compared to standard tumor growth, which might result in a greater rate of growth of melanoma with cnp. Significantly higher skin and tumor levels of citrulline in males were a distinctive feature, in contrast to melanoma with standard growth, which could be the result of inhibition of arginine synthesis and formation of a tumor auxotrophic for arginine.
A Review on the Effect of Kinesiotaping on Lung Function and Perception of Dyspnea in COPD Patients
Authors: Alsaeedi Mira Abdelaziz Ahmed Salim , Alaparthi Gopala Krishna , Kulkarni Manjiri , Bairapareddy Kalyana Chakravarthy 
Published: June 2021

Background:
Chronic Obstructive Pulmonary Disease (COPD) is complicated by the
presence of frequent and recurrent acute exacerbations. The patients are asymptomatic and stable
in the early stages. They develop weakness of primary respiratory muscles and use accessory muscles,
which lead to postural changes. The forward head posture is very common in COPD patients
due to increased usage of accessory muscles and aging changes. Kinesiotaping application has
been used to correct posture and lung function recently.

Objective:
The aim of this paper is to review the evidence on the effect of Kinesiotaping on lung
function and posture in COPD patients.

Methods:
The research articles published in the major databases including Web of Science,
Pubmed, and Google Scholar, were searched from January 2010 to January 2021 to be included in
the review. Twenty-one articles were retrieved and six articles were selected for the review based
on the inclusion criteria.

Results:
The studies indicate that Kinesiotaping of the thoracic wall in COPD patients has an immediate
effect on accessory inspiratory muscle activity, chest expansion, pulmonary function, and postural
alignment. Further research is required to determine the long-term effects of this special taping
method in comparison with conventional therapy in COPD patients.

Conclusion:
The application of kinesiotaping as an adjunct to conventional breathing exercises in
COPD patients helps in improving lung function, posture and reduces the perception of dyspnea.
New Insights on the UV/TiO2 Photocatalytic Treatment of Thiomersal and its 2-Sulfobenzoic Acid Product
Authors: de la Fournière Emmanuel M. , Meichtry Jorge M. , Custo Graciela S. , Gautier Eduardo A. , Litter Marta I. 
Published: June 2021

Background:
Thiomersal (TM), a complex between 2-mercaptobenzoic acid (2-MBA) and
ethylmercury (C2H5Hg+), is an antimicrobial preservative used in immunological, ophthalmic, cosmetic
products, and vaccines.

Objective:
TM has been treated by UV/TiO2 photocatalysis in the presence or absence of oxygen at
acidic pH. C2H5Hg+, 2-MBA, and 2-sulfobenzoic acid (2-SBA) were found as products. A 2-SBA
photocatalytic treatment was undertaken to study sulfur evolution.

Methods:
Photocatalytic runs were performed using a UVA lamp (λmax = 352 nm), open to air or under
N2. A suspension of the corresponding TM or 2-SBA salt and TiO2 was prepared, and pH was adjusted.
Suspensions were stirred in the dark for 30 min and then irradiated. TM, 2-MBA, 2-SBA, and
C2H5Hg+ were quantified by HPLC, sulfur by TXRF, and the deposits on the photocatalyst were analyzed
by chemical reactions. The mineralization degree was followed by TOC. Sulfate was determined
using BaCl2 at 580 nm.

Results:
Photocatalytic destruction of TM and total C2H5Hg+ was complete under N2 and air, but TM
degradation was much faster in air. The evolution of TM and the products followed a pseudo-first order
kinetics.

Conclusion:
TiO2-photocatalytic degradation is a suitable technique for the treatment of TM and its
degradation products. In contrast to other organomercurial compounds, TM degradation is faster in the
presence of O2, indicating that the oxidative mechanism is the preferred pathway. A significant TM
mineralization (> 60%, NPOC and total S) was obtained. TM was more easily degraded than 2-SBA.
Sulfate was the final product.