bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGGUNAAN MEDIA FLASH PLAYER PADA PEMBELAJARAN IPS
Authors: Syafi’aturrosyidah Mustika 
Published: April 2021

Abstrak
Ilmu Pendidikan Sosial (IPS) merupakan ilmu penelaahan atau kajian tentang masyarakat. Dalam mengkaji masyarakat, terdapat berbagai perspektif sosial, seperti kajian melalui pengajaran sejarah, geografi, ekonomi, sosiologi, antropologi, politik-pemerintahan, dan aspek psikologisosial yang disederhanakan untuk mencapai tujuan pembelajaran. Pada kenyataannya banyak siswa yang kurang bisa memahami inti dari pelajaran IPS, bahkan merasa bosan dengan pembelajaran yang didominasi dengan ceramah. Oleh karena itu, diperlukannya sebuah media pembelajaran yang menarik dalam proses pembelajaran. Salah satu media pembelajaran yang dapat diterapkan dalam pembelajaran IPS adalah media flash player. Flash player merupakan media yang berbentuk buku digital atau yang biasa disebut dengan e-book dalam pembelajaran IPS. Implementasi pembelajaran buku digital dapat berfungsi sebagai media dan sumber belajar. Penggunaan buku digital pada pembelajaran IPS adalah upaya pendidik untuk memanfaatkan teknologi informasi dan komunikasi dalam menyampaikan materi pelajaran kepada peserta didik.
KELUARGA ISLAMI SEBAGAI BASIS PENDIDIKAN DASAR ANAK
Authors: Yusron Akhmad 
Published: April 2021

Abstrak
Orang tua merupakan pemegang amanah dalam memberikan kebutuhan biologis, merawat, dan memberikan pendidikan. Lingkungan keluarga punya peranan penting dalam pendidikan anak dititikberatkan pada curahan kasih sayang yang mengiringi proses pendidikan.
Dimensi praktis pendidikan Islam memerlukan pengawasan yang optimal yang dapat diberikan oleh orang tua dalam lingkungan kelurga. Keluarga Islami melalui implementasi Living Sunnah dan dioptimalkan dengan beberapa metode, seperti; keteladanan, Pembiasaan, Hukuman, dan Nasehat.
Metode Pembiasaan dapat dilakukan oleh keluarga Islami melalui perintah menutup aurat, salat berjamaah lima waktu, dan sebagainya. Implementasi metode Pembiasaan, metode Nasehat harus terintegrasi dengan metode Keteladanan.
Manajemen Bimbingan Dan Konseling Dalam Pendidikan Karakter Peserta Didik
Authors: Hidayat Wahyu , Suryana Yaya , Fauziah Fia 
Published: April 2021

Kegiatan Bimbingan dan Konseling memegang peranan yang sangat penting dalam menumbuhkembangkan karakter siswa madrasah. Oleh karena itu, kegiatan bimbingan dan konseling harus ditata dan kelola secara sistematis dengan mengimplementasikan fungsi-fungsi manajemen, Penelitian ini bertujuan untuk mengetahui (1) perencanaan, (2) pengorganisasian (3) pelaksanaan (4) evaluasi (5) faktor penunjang dan penghambat (6) Hasil yang dicapai dari manajemen bimbingan dan konseling dalam pendidikan karakter peserta didik. Metode penelitian yang digunakan bersifat deskriptif-kualitatif, teknik pengumpulan data dilakukan melalui wawancara, observasi dan studi dokumentasi atau menyalin. Hasil penelitian ini menunjukan bahwa Manajemen bimbingan dan konseling dalam pendidikan karakter peserta didik telah berjalan cukup baik yang ditunjukan dengan beberapa hal berikut, yaitu: (1) perencanaanya secara adminstrasi sudah cukup baik. (2) pegorganisasiannya dilakukan sistem koordinasi baik antara guru bimbingan dan konseling dengan guru-guru mata pelajaran ataupun wali kelas. (3) pelaksanaanya disesuaikan dengan program-program yang telah di rumuskan sebelumnya.(4) evaluasi dilakukan dalam bentuk laporan.(5) faktor penunjangnya yaitu pemahaman Bimbingan Konseling seluruh civitas akademika baik, Sementara faktor penghambatnya kurangnya sumber daya manusia menyebabkan kurang optimalnya dalam pelaksanaan bimbingan dan konseling (6) hasil yang dicapai dilihat dari perubahan tingkah laku serta prestasi peserta didik.
Kata Kunci: Bimbingan, Konseling, Karakter
Time Trend of Swine Flu at a Tertiary Care Centre of Western Rajasthan: A Decadal Analysis
Authors: Verma Manoj , Bhansali Suman , Kumar Arun 
Published: April 2021

Background: Swine flu had been established as seasonal influenza, but antigenic variation continues to result in epidemics that necessitate continued surveillance. Present study aims to describe the time trend of swine flu from its initiation in 2009 to 2019 from western zone of Rajasthan.
Material and Methods: This secondary analysis of swine flu data from established seasonal disease reporting was conducted at a tertiary care centre of western Rajasthan which was the only swine flu testing centre in this area. Only Lab confirmed cases from this centre were included for month wise distribution.
Results: First case from Jodhpur was seen in August 2009. Large peaked outbreaks were seen around every 4 years namely 2009-10, 2014-15, 2018-19 corresponding to the antigenic variation of this virus namely California, Michigan and Brisbane strain respectively. Cases were seen in mostly in winters with peak in December/January. Mortality rate among these lab confirmed cases varied from 0–22% in different outbreaks.
Conclusion: Continued laboratory surveillance is necessary to identify the time pattern of outbreaks and for early identification of emergence of new strain to ensure early and timely preparedness for impending epidemics.
Regulation of Exosomes in the Pathogenesis of Breast Cancer
Authors: Shi Congjian , Yang Hongqin , Wang Zhengchao , Zhang Zhenghong 
Published: April 2021

Extracellular vesicles (EVs) are a heterogeneous group of endogenous nanoscale vesicles that are secreted by various cell types. Based on their biogenesis and size distribution, EVs can be broadly classified as exosomes and microvesicles. Exosomes are enveloped by lipid bilayers with a size of 30–150 nm in diameter, which contain diverse biomolecules, including lipids, proteins and nucleic acids. Exosomes transport their bioactive cargoes from original cells to recipient cells, thus play crucial roles in mediating intercellular communication. Breast cancer is the most common malignancy among women and remains a major health problem worldwide, diagnostic strategies and therapies aimed at breast cancer are still limited. Growing evidence shows that exosomes are involved in the pathogenesis of breast cancer, including tumorigenesis, invasion and metastasis. Here, we provide a straightforward overview of exosomes and highlight the role of exosomes in the pathogenesis of breast cancer, moreover, we discuss the potential application of exosomes as biomarkers and therapeutic tools in breast cancer diagnostics and therapeutics.
Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Ghosh Sukanya 
Published: April 2021

Arrythmogenic right ventricular cardiomyopathy (ARVC) is a genetic form of cardiomyopathy causing fibro-fatty replacement of the myocardium. Although usually transmission is autosomal dominant, 12 genes encoding cardiac desmosomes have been found to be closely linked to this disease process shifting the congenital disease theory to a genetic one. The categorisation of ARVC as a myocyte adhesion disorder was first suggested by a molecular genetic study involving patients with Naxos disease. Misnomeric to only affect the right ventricle, ARVC also affects the left ventricle - culminating into biventricular failure as a long term prognosis. Epidemiology is well established with a male to female preponderance. It is currently the second most common cause of sudden cardiac death (SCD) in population < 35 yrs. Pathological basis of the varied clinical presentation is explained at the molecular level with myocardial atrophy, fibro-fatty replacement and chamber dilatation. Diagnosing the condition by ruling out the pitfall differentials is an enormous challenge due to the broad phenotypic spectrum including syncope on one end and SCD on the other. Task Force Criteria combines electrocardiography (ECG), echocardiography (ECHO), cardiac magnetic resonance imaging (CMRI), myocardial biopsy for diagnosis; early detection, family screening and risk stratification being the cornerstones. Therapeutic options although limited due to the progressive nature of the disease is based on preventing life threatening arrhythmias encompassing primary and secondary prevention - Implantable cardioverter -defibrillator (ICD) implantation, radiofrequency ablation and heart transplantation are the main ones.
Reversible Cardiomyopathies
Authors: Shah Niel , Rodriguez-Guerra Miguel , Saad Muhammad , Kang Anthony , J. Vittorio Timothy 
Published: April 2021

Cardiomyopathy includes a diverse and heterogeneous group of disorders affecting the myocardium and eventually leading to cardiac dysfunction. Cardiomyopathy is the leading cause of hospitalization in patients older than 65 years of age and it is an important cause for enormous healthcare expenditure. All reversible cardiomyopathies can be associated with cardiomegaly, systolic heart failure, structural changes, and an increase in mortality, but when the offensive agent is identified and stopped, these conditions tend to stop their progression and reverse. The prognosis of reversible nonischemic cardiomyopathies is better than ischemic or other nonreversible cardiomyopathies. Additionally, it is important to diagnose etiology of HF early and precisely to determine prognosis and effective treatment. Most patients with reversible cardiomyopathy present with clinical picture similar to that of systolic heart failure. Here in this book chapter, we discuss about different types of reversible cardiomyopathy including pathogenesis, clinical picture, diagnosis and treatment.
Antifungal Activity of Annona muricata Seed Extracts Against Cercospora malayensis, Causal Agent of Cercospora Leaf Spot Disease of Okra (Abelmoschus esculentus L.)
Authors: Bolie Hubert , Ndongo Bekolo , Ngatsi Patrice Zemko , Kuate William Norbert Tueguem , Dida Sylvere Landry Lontsi , Essogue Etame Arnaud , Essomé Charles Salé , Tonfack Libert Brice 
Published: April 2021

Background: Cercospora leaf spot disease of okra whose pathogen is Cercospora malayensis causes yield losses of up to 60% in plantations. To limit productivity losses, fungicides are commonly used, but are expensive and degrade the environment.
Aims: This study aims to test in vitro efficacy of Annona muricata seed extracts against Cercospora malayensis.
Study Design: Four extracts were used in this study (the ethyl acetate, acetone, methanol and aqueous extract of A. muricata seeds at the concentrations C1 = 7.5 μl/ml, C2 = 15 μl/ml, C3 = 30 μl/ml and C4 = 60 μl/ml as well as the synthetic fungicide at the concentration of 3.33 g/l) in triplicate. The phytochemical screening of the extracts was performed, the radial growth of pure explants (7 mm diameter) of C. malayensis deposited in sterile Petri dishes containing the PDA medium supplemented with the different concentrations of extracts and incubated at 23 ± 1°C for 6 days were evaluated. Minimum inhibitory concentrations (MIC50, MIC90) were calculated.
Results: The extracts of A. muricata seeds are rich in tannins, flavonoids, terpenoids and phenols. The ethyl acetate extract at the concentration C3 resulted in 100% total inhibition of growth of C. malayensis in the Petri dishes. The other extracts resulted in total inhibition of the growth of C. malayensis at C4. The low MIC50 values (12.9 and 21 μl/ml) were obtained with the ethyl acetate and acetone extract, respectively. The ethyl acetate and aqueous extract at the C4 concentration were found to be fungicidal.
Conclusion: The extracts were found to be potential fungicide against the C. malayensis strain and might be an alternative in the fight against fungal diseases of okra as their activity was comparable to that of the synthetic fungicide Monchamp 72 WP.
Spatial Pattern of Soil Carbon Density in Cultivated Land of Different Domains of Madhya Pradesh
Authors: Tagore G. S. , Sharma Y. M. , Sharma R. , Bairagi G. D. , Dwivedi A. K. , Kulhare P. S. , Vishwakarma Megha 
Published: April 2021

Present study was conducted in the Department of Soil Science JNKVV, Jabalpur during 2018-2020. GPS based 531 soil samples were collected from each domain viz., Bhopal, Jabalpur, Vidisha and Hoshangabad of 10.1 Agro ecological sub region (AESR). The samples analyzed for soil organic carbon (SOC) and calcium carbonate (CaCO3) then soil organic carbon density (SOCD), total organic carbon density (TOCD), soil inorganic carbon density (SICD) and total carbon density (TCD) in Mg C ha-1 were calculated. The results of SOCD, TOCD, SICD and TCD ranged from 4.73 to 25.12, 9.22 to 48.98, 1.00 to 21.29 and 11.08 to 68.80 Mg C ha-1 with mean value of 12.19, 23.78, 7.58 and 31.36 Mg C ha-1 in AESR 10.1 and Coefficient of variation (CV) 37.58, 37.58, 50.88 and 31.24 %. The overall trend in SOCD was Bhopal > Vidisha > Jabalpur > Hoshanagabad and SICD was Vidisha > Hoshanagabad > Jabalpur >Bhopal while TCD was in trend of Bhopal > Vidisha > Hoshangabad> Jabalpur.
Geo-statistical indicated that Ordinary Kriging used and all variogram were in isotropic form. In Bhopal domain, Gaussian model best fitted for of SOCD, TOCD, and TCD but spherical model for SICD. In Jabalpur domain, exponential domain best fitted for TCD and TOCD but for SICD, spherical model and for SOCD, Gaussian model is best fitted. In Vidisha domain, exponential model best fitted for all. In Hoshangabad domain, exponential model is best fitted for SOCD and TOCD and Gaussian and J-Bessel model best fitted for TCD and SIC, respectively. The nugget/ sill (N/S) ratio was <25% which exhibit strong SD only for SICD in Bhopal domain. The N/S ratio was found to be >25% but <75% which showed moderate SD, for SOCD, TOCD and TC, TOCD, SICD and TCD; SOCD, TOCD, SICD and TCD and SOCD, TOCD, SICD and TCD in Bhopal, Jabalpur, Vidisha and Hoshangabad domain, respectively. The correlation range (m) for SOCD, TOCD, SICD and TCD are 5448.413, 4809.535, 360.522, and 5113.050; 7201.044, 6601.044, 611.651, and 8438.711; 5734.559, 7334.398, 1323.773, and 7881.289 and 5418.684, 5433.206, 8887.656, and 1836.274 in Bhopal, Jabalpur, Vidisha and Hoshangabad domain, respectively. The carbon density was found in order of Jabalpur> Hoshangabad >Vidisha > Bhopal.
The Darwin-Breit Interaction vs. the Aharonov-Bohm Potentials
Authors: Comay E. 
Published: April 2021

The paper shows that the Darwin-Breit form of electromagnetic interaction disproves the Aharonov-Bohm assertion about the fundamental meaning of the electromagnetic potentials in quantum theory. A specific analysis of the Aharonov-Bohm electric and magnetic effects substantiates this result.
Teaching strategies in addressing palliative care with nursing professionals: integrative review / Estratégias de ensino na abordagem dos cuidados paliativos com profissionais de enfermagem: revisão integrativa
Authors: Silva Tatiana Pifano , Silva Liliane Faria , Cursino Emilia , Pacheco Sandra , Acioly Paloma , Silva Ingrid Pifano 
Published: April 2021

Objetivo: identificar, nas produções científicas, as estratégias de ensino utilizadas na abordagem dos cuidados paliativos com profissionais de enfermagem. Método: revisão integrativa nas seguintes bases de dados: CINAHL, PUBMED, LILACS, SCIELO e BDENF. Resultados: foram analisados 12 artigos, todos internacionais. Foram utilizadas várias estratégias de ensino como: palestras, simulação, discussão em grupos, dramatizações, aula expositiva. A metodologia ativa foi a mais utilizada, com a associação de várias estratégias de ensino, sendo o estudo de caso a mais frequente. Conclusão: a associação da teoria com a simulação da prática clínica é uma boa estratégia de ensino. Maior ênfase tem que ser dada na capacitação dos profissionais de enfermagem através de atividades de educação permanente em cuidados paliativos visando fornecer uma assistência segura e qualificada para o paciente e sua família.
Educational actions developed by nurses to adolescents in family health strategies / Ações educativas desenvolvidas por enfermeiros aos adolescentes nas estratégias de saúde da família
Authors: Nietsche Elisabeta Albertina , Terra Larice Gonçalves , Salbego Cléton , Cogo Silvana Bastos , Ramos Tierle Kosloski , Da Conceição Joseph Wrague 
Published: April 2021

Objetivo: conhecer como são desenvolvidas as ações educativas voltadas aos adolescentes no contexto de trabalho do enfermeiro nas Estratégias de Saúde da Família. Método: Pesquisa qualitativa, descritiva exploratória desenvolvida com 10 enfermeiros de Estratégias Saúde da Família. A coleta dos dados ocorreu no mês de maio de 2015, por meio de entrevista semiestruturada. Os dados foram analisados a luz da análise de conteúdo. Resultados: Duas categorias emergiram para análise, sendo: ações educativas aos adolescentes na perspectiva dos enfermeiros e características das ações educativas desenvolvidas com adolescentes. Conclusão: O estudo possibilitou perceber que as ações educativas são desenvolvidas em coletividade, desde o planejamento e execução, na maioria das Estratégias Saúde da Família, e nos locais onde isso não ocorre, os enfermeiros compreendem a necessidade de iniciar um trabalho em equipe. O enfermeiro é percebido como responsável por coordenar a equipe, e orientar o processo de preparação das ações educativas.
Hospital discharge management of premature newborns: nurses’ knowledge / O manejo da alta hospitalar do recém nascido prematuro: saberes dos enfermeiros
Authors: Anacleto Luziane de Almeida , Alves Valdecyr Herdy , Rodrigues Diego Pereira , Vieira Bianca Dargam Gomes , Pereira Audrey Vidal , Almeida Vivian Linhares Maciel 
Published: April 2021

Objetivo: analisar os saberes dos enfermeiros durante o processo de alta hospitalar do recém nascido prematuro.Método: estudo descritivo, exploratório, qualitativo, realizado entre janeiro e maio de 2019 em uma unidade neonatal do Hospital Municipal Dra. Naelma Monteiro da Silva, vinculado ao Município de Rio das Ostras, Estado do Rio de Janeiro. Participaram do estudo onze enfermeiros atuantes na Unidade, sendo os dados coletados por meio de entrevista semiestruturada submetidos à análise de conteúdo na modalidade temática. Resultados: constatou-se que os enfermeiros demonstraram conhecimento dos saberes acerca dos cuidados ao recém nascido na alta hospitalar, destacando-se a amamentação, a higiene corporal, o coto umbilical, a criação de vínculo e o plano de alta hospitalar com o propósito de evitar as reinternações. Conclusão: há necessidade de uma assistência qualificada, segura e humanizada, com acolhimento e respeito às subjetividades, tendo como propósito conhecer as necessidades do recém nascido, e promover estratégias para a educação em saúde, em especial no que tange aos cuidados do recém-nascido prematuro.
Xerostomia and breast cancer / Xerostomia e câncer de mama
Authors: Pinto Vânia Lopes , Westphal Flavia , Elias Simone 
Published: April 2021

Objetivo: identificar os estudos que descrevem a prevalência de xerostomia em pacientes com câncer de mama e em quimioterapia. Método: revisão integrativa, partindo da questão norteadora << Quais as evidências científicas sobre a prevalência de xerostomia em pacientes com câncer de mama e em quimioterapia? >>. Foi realizada uma busca nas bases de dados PubMed, LILACS e SciELO por meio dos Descritores em Ciências da Saúde. Foram encontrados 63 artigos, que foram analisados por dois pesquisadores seguindo os critérios de inclusão e exclusão. Resultados: a prevalência de xerostomia foi descrita em 10 artigos que utilizaram como método de avaliação escalas, questionários com respostas dicotômicas e sialometria. Conclusão: identificou-se uma prevalência de 47% a 77,3% de xerostomia durante a quimioterapia.
The Gut Microbiome
Authors: Francella Cassandra , Foster Jane A. 
Published: April 2021

AbstractIn the past decade, there has been a remarkable growth in the interest and enthusiasm for microbiome research. The microbiome includes bacteria, viruses, fungi, and parasites; our microbes cover all parts of our body. Researchers from many disciplines are now considering the role of microbiota and its relationship to development, physical health, and mental health. The multidisciplinary nature of ongoing research efforts is advancing our knowledge base at a fast pace. The current attention to tool development for analysis beyond bacterial composition will help scientists interpret the relationship between microbes, health, and disease. This article provides an introduction to host–microbe interactions based on animal and clinical research focused on the gut microbiome.
Antitubercular Agents
Authors: Aldrich Courtney C. , Wallis Robert S. , Remmel Rory P. , Hegde Pooja , Stallings Christina L. 
Published: April 2021

AbstractMycobacterium tuberculosisremains the leading cause of death due to infection in humans. Although antibiotics are available to treat drug‐sensitiveM. tuberculosisinfections, the increasing incidence of drug‐resistant strains is threatening our ability to gain hold of this pandemic. In addition, recent research has highlighted that even the current standard of care antibiotics face multiple obstacles for reaching therapeutic concentrations at the site of infection. In this article, we detail the current standard of care for clinical tuberculosis (TB) disease, the chemistry, mechanisms of action, and mechanisms of resistance for the antibiotics used clinically to treat TB, the growing problem of antibiotic resistance, and other challenges associated with TB treatment, and host‐directed therapies as an additional approach to treatment. This article is meant to serve as the foundation to build from as the field addresses the dire need for continued development of new therapeutic strategies to treat TB.
Genetics of the Congenital Myopathies
Authors: Pelin Katarina 
Published: April 2021

Abstract

The congenital myopathies are a heterogeneous group of skeletal muscle disorders characterised by muscle weakness present at birth and typical abnormalities in skeletal muscle fibres, such as protein aggregates, centrally located nuclei or areas lacking mitochondria. Mutations in more than 30 different genes can cause a congenital myopathy. The inheritance can be autosomal dominant, autosomal recessive or X‐linked or sporadic due to novel mutations. The mutated genes can be divided into three groups: genes encoding proteins of the skeletal muscle sarcomere, genes encoding proteins of the sarcoplasmic reticulum and transverse tubules and genes encoding proteins regulating muscle growth and regeneration. The mutations cause impaired or reduced muscle contraction by damaging the contractile machinery or by altering the regulation of muscle contraction, leading to muscle weakness.

There is considerable clinical and histological overlap between the different types of congenital myopathies.

The inheritance can be autosomal dominant, autosomal recessive or X‐linked or sporadic (
de novo
mutations).

Disease‐causing variants in more than 30 different genes can cause a congenital myopathy.

Disease‐causing variants in the same gene can result in more than one clinical phenotype, and the same clinical phenotype can result from mutations in several different genes.

The genes encode proteins essential for skeletal muscle development, muscle contraction, structure and protein turnover.