bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 IgG response in symptomatic and asymptomatic COVID-19-infected healthcare workers
Authors: Cordova E , Bacelar B , Nieto F , Garibaldi F , Aguirre V , Machuca M , Badia M , Rodriguez C 
Published: April 2021

Abstract

Background
Healthcare workers (HCWs) accounted for a significant proportion of COVID-19 infections worldwide. Retrospective seroprevalence surveys are often used to screen for unidentified previous infection with SARS-CoV-2. However, the rate of humoral response in HCWs affected by COVID-19 is not well-defined.

Aims
To assess the specific IgG humoral response in symptomatic and asymptomatic SARS-CoV-2-infected HCWs and identify potential factors associated with humoral response.

Methods
We prospectively recruited 204 HCWs with RT-PCR-confirmed COVID-19 infection to evaluate SARS-CoV-2 humoral response. Serum-IgG antibodies against SARS-CoV-2 were analysed using two commercially available serological assays. A logistic regression was performed to identify independent factors associated with positive IgG serology test.

Results
Overall, the SARS-CoV-2 IgG seropositivity rate was 77%. This seropositivity rate was higher in symptomatic than in asymptomatic COVID-19 infection (83% versus 57%; P &lt; 0.001) and in older HCWs.. The seropositivity rate did not diminish with time. In logistic regression, only a history of COVID-19 symptoms and age were identified as independent factors associated with the detection of anti-SARS-CoV-2 IgG antibodies.

Conclusions
SARS-CoV-2 IgG antibodies are found significantly more frequently in symptomatic and in older HCWs. The fact that not all COVID-19 HCWs develop detectable IgG is vital for the interpretation of COVID-19 seroprevalence surveys.
Community characteristics of forest understory birds along an elevational gradient in the Horn of Africa: A multi-year baseline
Authors: Kittelberger Kyle D , Neate-Clegg Montague H C , Buechley Evan R , Hakkı Şekercioğlu Çağan 
Published: April 2021

AbstractTropical mountains are global hotspots for birdlife. However, there is a dearth of baseline avifaunal data along elevational gradients, particularly in Africa, limiting our ability to observe and assess changes over time in tropical montane avian communities. In this study, we undertook a multi-year assessment of understory birds along a 1,750 m elevational gradient (1,430–3,186 m) in an Afrotropical moist evergreen montane forest within Ethiopia’s Bale Mountains. Analyzing 6 years of systematic bird-banding data from 5 sites, we describe the patterns of species richness, abundance, community composition, and demographic rates over space and time. We found bimodal patterns in observed and estimated species richness across the elevational gradient (peaking at 1,430 and 2,388 m), although no sites reached asymptotic species richness throughout the study. Species turnover was high across the gradient, though forested sites at mid-elevations resembled each other in species composition. We found significant variation across sites in bird abundance in some of the dietary and habitat guilds. However, we did not find any significant trends in species richness or guild abundances over time. For the majority of analyzed species, capture rates did not change over time and there were no changes in species’ mean elevations. Population growth rates, recruitment rates, and apparent survival rates averaged 1.02, 0.52, and 0.51 respectively, and there were no elevational patterns in demographic rates. This study establishes a multi-year baseline for Afrotropical birds along an elevational gradient in an under-studied international biodiversity hotspot. These data will be critical in assessing the long-term responses of tropical montane birdlife to climate change and habitat degradation.
Filoplume morphology covaries with their companion primary suggesting that they are feather-specific sensors
Authors: Rohwer Vanya G , Rohwer Sievert , Kane Larissa 
Published: April 2021

Abstract
Do birds detect and respond to forces acting on feathers through filoplumes, which appear to be unique mechanosensory feathers? If filoplumes function as sensors, their morphology should covary with the morphology of their companion feather to better detect feather movements and position. We explore covariation in filoplumes and primaries across 5 species of birds that vary in body size, molt strategy, and the functional life span of their primaries (Green-winged Teal [Anas crecca], Ring-billed Gull [Larus delawarensis], Turkey Vulture [Cathartes aura], Red-tailed Hawk [Buteo jamaicensis], and Red-winged Blackbird [Agelaius phoeniceus]). Filoplumes never extended beyond the coverts and inserted immediately adjacent to the base of their companion primaries, positioning them to detect subtle changes in feather vibration or movement. Far more variation in filoplume number and morphology was due to species differences than to individuals or position in the wing. Across species, filoplume length and number increased with calamus length of primaries. In the 2 species with growing primaries, the number and length of filoplumes were only weakly associated with molting primaries, suggesting that filoplumes were not replaced when their companion primary was replaced. Further, filoplumes associated with a growing primary were not replaced synchronously, leaving others to sense primary position and movement. Finally, filoplume number and length were greatest in Red-tailed Hawks, a species that carries individual feathers for multiple years, but links between filoplume morphology and molt strategy await broader comparative studies. Taken together, the morphology of filoplumes and their replacement schedule relative to their associated primary suggests that they are sensors, capable of detecting subtle differences in the position and movement of their companion feathers.
The Post-Normal Challenges of COVID-19: Constructing Effective and Legitimate Responses
Authors: Rainey Stephen , Mormina Maru , Lignou Sapfo , Nguyen Joseph , Larsson Paula 
Published: April 2021

AbstractThe ongoing COVID-19 emergency clearly presents novel challenges, both in terms of difficulties for maintaining public health and in assuring that governmental responses are ethically sound. Centrally, responses must respect, as best as possible, fundamental human rights and human values. Conflicts among values arise in response to the crisis, and public officials have no choice but to prioritize some while sacrificing others. Utilizing the concepts of effectiveness and legitimacy within the framework of post-normal science (PNS), we investigate and recommend processes and measures to address COVID-19 that support increased public health, while upholding established rights and values. The effectiveness and legitimacy of science-led policymaking requires investigation of how that policy ought to be made (e.g. concepts of policymaking and PNS), as well as how it ought to interact with diversely-constituted publics (e.g. public inclusion in policymaking and policy communication).
Randomized controlled trial of the mySmartSkin web-based intervention to promote skin self-examination and sun protection among individuals diagnosed with melanoma
Authors: Manne Sharon L , Heckman Carolyn J , Kashy Deborah A , Ritterband Lee M , Thorndike Frances P , Lozada Carolina , Coups Elliot J 
Published: April 2021

Abstract
Adherence to regular, thorough skin self-examination (SSE) and consistent sun protection behaviors among melanoma survivors is relatively low. This study reports on the impact of an online intervention, called mySmartSkin (MSS), on engagement in SSE and sun protection behaviors among melanoma survivors, as well as the mediators of the intervention effects. The intervention was compared with usual care (UC), and primary outcomes were assessed at 24 and 48 weeks. Short-term outcomes were also evaluated at 8 weeks postbaseline. Results demonstrate a significant effect on SSE and sun protection. At all three follow-up assessments, the proportion of participants reporting conducting a thorough SSE in the time since the previous assessment was significantly greater in MSS than in UC. In addition, both multivariate and univariate analyses indicated that engagement in sun protection behaviors was significantly higher in MSS than UC at 24 weeks, but the effect on sun protection at 48 weeks was significant only in multivariate analyses. Beneficial effects of MSS were significantly mediated by knowledge about melanoma and characteristics of suspicious lesions, as well as self-efficacy. Participant engagement in MSS was satisfactory, with approximately two-thirds of participants completing at least two of the three core components. Content was rated as highly trusted, easy to understand, easy to navigate, and helpful. In conclusion, MSS illustrated significant and durable effects on SSE and mixed results on sun protection. Future studies should consider ways to further enhance treatment effects and engagement in MSS.
Perceived impacts of the COVID-19 pandemic on cannabis-using emerging adults
Authors: Bonar Erin E , Chapman Lyndsay , McAfee Jenna , Goldstick Jason E , Bauermeister José A , Carter Patrick M , Young Sean D , Walton Maureen A 
Published: April 2021

Abstract
Cannabis-using youth are a large epidemiologic subgroup whose age and smoking-related risks underscore the importance of examining the impact of the COVID-19 pandemic in this population. Within a clinical trial (n = 36 received an intervention prior to data collection reported herein), we surveyed cannabis-using emerging adults (ages 18–25) about perceived COVID-19 impacts. Participants (n = 141) reporting weekly cannabis use (M = 18.6 use days in the past 30) were enrolled and completed online surveys as part of either their baseline or 3 month assessment. COVID-19-related measures included symptoms, substance use, mood, etc. Participants were 57% female (mean age = 21, standard deviation = 2.2), with 21% Hispanic/Latinx, 70% White, 20% Black/African American, and 10% of other races. Most participants (86%) reported quarantine/self-isolation (M = 59 days). Several had COVID-19 symptoms (16%), but none reported testing COVID-19 positive. Many respondents felt their cannabis use (35%–50%, across consumption methods) and negative emotions (e.g., loneliness, stress, and depression; 69.5%, 69.5%, and 61.8%, respectively) increased. They reported decreased in-person socialization (90.8%) and job losses (23.4%). Reports of increased cannabis smoking were associated with increased negative emotions. On an open-response item, employment/finances and social isolation were frequently named negative impacts (33.3% and 29.4%, respectively). Although cannabis-using emerging adults’ reports of increases in cannabis use, coupled with mental health symptoms and social isolation, are concerning, the full impact of the pandemic on their health and well-being remains unknown. Future studies examining the relationship between social isolation, mental health, and cannabis use among young people are needed.
Presentation of a branchial cleft anomaly in an adult
Authors: Wojtas Emily , Mendez Anthony , Donald Carrlene , Hinni Michael 
Published: April 2021

ABSTRACT
Branchial cleft anomalies are the second most common type of congenital neck mass and typically are diagnosed in patients under age 5 years. This article describes a rare presentation of an adult with a branchial cleft anomaly.
A rare cause of a cavitary lung lesion in an infant
Authors: Tesoriero Sarah Macios , Gross Elissa 
Published: April 2021

ABSTRACT
Paraesophageal hernias in children are rare, and can occur congenitally or be acquired. Acquired cases most often follow anti-gastroesophageal reflux surgery, or less commonly trauma. In children, elective repair is encouraged at the time of diagnosis to prevent future life-threatening complications.
Optimal Lumbar Lordosis Correction for Adult Spinal Deformity with Severe Sagittal Imbalance in Patients Over Age 60
Authors: Lee Ki Young , Lee Jung-Hee , Im Sang-Kyu 
Published: April 2021

Study Design.
A retrospective study.

Objectives.
The purpose of this study was to evaluate optimal and ideal target values of the spine balance correction in elderly patients with adult spinal deformity who were over the age of 60 years.

Summary of Background Data.
The target values of the Scoliosis Research Society -Schwab classification to obtain satisfactory alignment and favorable outcomes are used in many spinal reconstruction surgeries. However, uniformly applying the Scoliosis Research Society-Schwab classification to all elderly patients aged 60 years or older showing sagittal malalignment may lead to several inconsistencies.

Methods.
This study included 121 patients (average age 70.5 yr and a minimum 2-yr follow-up) with adult spinal deformity who underwent long-segment fusion from T10 to sacrum. We used Pearson's correlation coefficient to analyze the relationship between clinical and radiographic parameters, and multilinear regression analysis and multivariate logistic regression model (backward elimination method) were conducted using the correlation factors of postoperative (Post) and last follow-up (Last) sagittal vertical axis to find the risk factors of Post sagittal imbalance.

Results.
Logistic regression analysis with the correlation factors of Post and Last sagittal vertical axis led to risk factors of Post sagittal imbalance, and after confirming the significance of each path, it was confirmed that the effects of pelvic incidence (PI)— lumbar lordosis (LL) and Post pelvic tilt ratio (PTr) were valid (P < 0.05). After using ROC curve, target value of PI-LL was 1.33, and that of PTr was 25.95%.

Conclusion.
Through our study, the risk factors of Post sagittal imbalance were the Post value of PI-LL and that of PTr, and target value of PI-LL was <1.33 and that of PTr was <25.95%. These target values can be effective guidelines for spine surgeons who perform spine reconstruction surgeries for elderly patients with a pure sagittal imbalance based on Schwab's formula.

Level of Evidence: 4
Adolescent Sleep and Mental Health Across Race/Ethnicity: Does Parent-Child Connectedness Matter?
Authors: So Marvin , Perry Nicole B. , Langenfeld Adam D. , Barnes Andrew J. 
Published: April 2021

ABSTRACT:

Objective:
Sleep is vital for healthy development, yet most adolescents do not meet recommended nightly hours. Although racial/ethnic minorities often experience relatively worse sleep outcomes compared with White peers, little is known about how the sleep-mental health relationship holds across diverse groups or how family relationships affect this association.

Method:
Using data on 8th, 9th, and 11th grade public school respondents to the 2016 Minnesota Student Survey (N = 113,834), we conducted univariate, bivariate, and multivariate analyses to examine whether sleep duration was associated with depressive symptoms, suicide ideation, and suicide attempt, adjusting for sociodemographic covariates. Furthermore, we examined the effect of the parent-child connectedness by sleep interaction on these relationships. Analyses were conducted for 9 racial/ethnic groups collectively and separately.

Results:
Overall, youth sleep duration and parent-child connectedness were independently associated with reduced rates of depressive symptoms, suicide ideation, and suicide attempt. There was significant interaction between parent-child connectedness and sleep, demonstrating that connectedness magnifies the benefits of the sleep-mental health relationship. Main effects of sleep and parent-child connectedness for mental health were similar for most individual racial/ethnic groups, although magnitudes varied. The connectedness-sleep interaction only remained significant for White and Asian youth on select suicide-related outcomes.

Conclusion:
Despite racial/ethnic differences, adolescent sleep and parent-child connectedness both seem to buffer youth from poor mental health in a large, multiethnic sample. On the whole, these factors demonstrate a synergistic protective effect and reflect promising intervention targets. The extent to which their interactive benefit translates across diverse populations requires additional study.
Impact of Minimally Invasive Aesthetic Procedures on the Psychological and Social Dimensions of Health
Authors: McKeown Darren J. 
Published: April 2021

Background:
The impact on psychosocial health of injectable facial treatments such as hyaluronic acid fillers and botulinum toxin type A remains poorly defined. The aim of this study was to measure changes in psychosocial health following aesthetic intervention with injectables in routine clinical practice using the validated FACE-Q patient-reported outcome measure.

Methods:
This was a prospective assessment of patients presenting at a single center for the first time for aesthetic treatment of the face with injectables in February 2020. Participants completed 3 FACE-Q scales at the baseline and again 2 weeks posttreatment: Psychological Function; Social Function; and Appearance-related Psychosocial Distress.

Results:
Complete data were available for 35 individuals (n = 32 women [91%]; mean age: 45.9 ± 13.8 years). Twenty-nine (83%) were treated with hyaluronic acid filler (mean: 2.3 ± 1.3 syringes), and 12 (34%) received onabotulinumtoxinA (mean: 2.0 ± 0.7 areas of the upper face). There were significant improvements on each FACE-Q scale posttreatment: mean change in Psychological Function score was +12.4 [95% CI: 7.9, 16.9; P < 0.001; standardized effect size by Cohen’s d: 0.93]; mean change in Social Function score was +7.9 (95% CI: 3.3, 12.5; P = 0.001; effect size: 0.50); and mean change in Appearance-related Psychosocial Distress score was –20.9 (95% CI: –27.4, –14.3; P < 0.001; effect size: 1.27).

Conclusions:
Aesthetic treatment with injectables was associated with significant improvements in patient-reported psychological and social functioning and reductions in appearance-related distress. This change underlines the value of these therapies for improving psychosocial health in well-selected patients.
Intraocular lens subluxation and decompensated pseudoexfoliation glaucoma in a patient's only reading eye May consultation #1
Authors: Menapace Rupert 
Published: April 2021

An 89-year-old man had cataract surgery in 2005 in both eyes. At that time, he already had glaucoma that was well regulated with topical therapy and drusen maculopathy with incipient areal atrophy. Fifteen years later, the patient presented with a decrease in visual acuity of his only reading eye, his right eye.
Visual acuity 1 year before presentation was reported as 0.5, Jg2 in his right eye, 0.2, Jg15 in his left eye with drusen maculopathy in both eyes, and an atrophic macular scar in the left eye. Slitlamp biomicroscopy showed an inferotemporally decentered and wobbling intraocular lens (IOL)–capsular bag (CB) complex in the right eye, with the bag equator and a capsular tension ring (CTR) visible in a miotic pupil and pseudoexfoliation (PXF) material accumulated along the pupillary margin.
The implant specification cards showed an AcrySof MA60BM (Alcon Laboratories, Inc.) 18.50 diopters (D) 3-piece hydrophobic acrylic IOL and a 13/11 CTR (Ophtec BV). In the left eye, the IOL was well centered and stable. Intraocular pressure (IOP) was 38 mm Hg in the right eye and 13 mm Hg in the left eye with full topical therapy. The optic nerve head exhibited an estimated cup-to-disc ratio in the right eye of 0.7 with a contiguous residual rim and no excavation in the left eye. Optical biometry through the CB periphery measured an axial length of 25.50 mm. Keratometric astigmatism was 0.60 D at 45 degrees.
Given that the right eye is the only eye with reading capacity and additionally experiences decompensated PXF glaucoma, what would be your surgical options and preferred approach to optically rehabilitate this patient and reduce IOL to normal levels?
Combined administration of rifampicin, ethambutol, and clarithromycin for the treatment of tenosynovitis of the hand caused by Mycobacterium avium complex
Authors: Kaji Yoshio , Nakamura Osamu , Yamaguchi Konosuke , Nomura Yumi , Oka Kunihiko , Yamamoto Tetsuji 
Published: April 2021

Abstract
We report the clinical results and problems of combined administration of rifampicin, ethambutol, and clarithromycin (REC) for the treatment of Mycobacterium avium complex (MAC) infection of the hand (hand MAC).
Participants included 7 patients with hand MAC. After resection of the infected lesion, REC was prescribed for 12 months. For these patients, the site of infection, clinical course after initiation of REC, adverse drug effects (ADEs), and incidence of recurrence were evaluated.
Sites of infection were the flexor tenosynovium in 5 patients, extensor tenosynovium in 1 patient, and both flexor and extensor tenosynovium in 1 patient. ADEs of REC occurred in 5 patients, and included visual disturbance caused by ethambutol in 2 patients, liver function abnormality caused by rifampicin in 2 patients, and fever with diarrhea caused by rifampicin in 1 patient. For 2 of these 5 patients, desensitization therapy was applied and REC was able to be reinstated. In the remaining 3 patients, the causative drugs were discontinued and levofloxacin, a new quinolone, was administered. Complete healing was achieved in 5 patients, and recurrence was observed in 2 patients. These 2 patients with recurrence included 1 patient in whom REC was completed and 1 patient in whom REC therapy was modified due to ADE.
REC provided relatively good clinical results as a treatment for hand MAC. However, recurrences were observed even after the completion of REC and the use of an alternative drug. Optimal duration of REC and appropriate alternative drugs need to be identified in the future.
The status and comparison of ovarian reserve between fertile and infertile healthy Chinese women of reproductive age
Authors: Zhou Shan-Jie , Sun Tie-Cheng , Song Ling-Li , Yang Ming , Sun Xin-Ping , Tian Li 
Published: April 2021

Abstract
We aimed to investigate ovarian reserve status, and explore differences in ovarian reserve between fertile and infertile healthy Chinese women of reproductive age.
We recruited 442 fertile women aged 23 to 49 years (mean: 35.22 ± 4.91 years) as subjects, and 196 infertile women aged 23 to 46 years (mean: 32.34 ± 4.34 years) as controls. For all participants, a number of parameters were tested on days 2 to 4 of a spontaneous cycle, including basal serum follicle-stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), total testosterone, anti-Müllerian hormone (AMH), ovarian response prediction index (ORPI), and antral follicle count (AFC).
There were significant differences in terms of AFC, serum AMH levels, and ORPI among subject subgroups (10.58 ± 5.80; 2.533 ± 2.146 ng/mL; 1.28 ± 1.87; respectively), and among control subgroups (12.44 ± 5.69; 3.189 ± 2.551 ng/mL; 1.88 ± 2.68; respectively) (P < .01 for all). For both subjects and controls, AFC, AMH levels, and ORPI decreased gradually with increasing age, and presented with similar age-related trends; there were positive correlations between AMH and AFC (P < .001), and negative correlations between age and AFC, AMH, ORPI (P < .05 for all). There was a significant difference in age (P < .001), serum E2 (P < .01), and AMH (P < .01) levels between subjects and controls; however, when controlling for confounding factors (age, body mass index, total testosterone, and LH), we found no differences between the 2 groups with regards to the serum levels of AMH, FSH, E2, and AFC (P > .05 for all). Moreover, receiver operating characteristic curve analysis indicated that the significant variables of subjects and controls for evaluating ovarian reserve included age, AMH and ORPI, and ORPI was more valuable than other variables.
A diminished ovarian reserve was one of the manifestations caused by female aging. When confounding factors were controlled for, we found no differences in ovarian reserve when compared between fertile and infertile women, and no correlation with infertility.