bluuebunny/crossref_metadata_2025_split huggingface dataset:
Afatinib and radiotherapy, with or without temozolomide, in patients with newly diagnosed glioblastoma: results of a phase I trial
Authors: Saran Frank , Welsh Liam , James Allan , McBain Catherine , Gattamaneni Rao , Jefferies Sarah , Harris Fiona , Pemberton Karine , Schaible Jennifer , Bender Shaun , Cseh Agnieszka , Brada Michael 
Published: November 2021

Abstract
Background
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Amplification or overexpression of the epidermal growth factor receptor gene, part of the ErbB family, occur in approximately 40% and 60% of patients with GBM, respectively. We present data from a dose-finding study of the ErbB inhibitor afatinib in combination with radiotherapy (RT), with or without temozolomide (TMZ), in patients with GBM.

Methods
This was a phase I, open-label, 3 + 3 dose-escalation trial in patients with newly-diagnosed, histologically-confirmed grade 4 malignant glioma and proven O6-methylguanine-DNA methyltransferase gene promoter methylation status. The primary endpoint was the maximum tolerated dose (MTD) of continuous daily afatinib when given in combination with RT, with (regimen M) or without (regimen U) concomitant TMZ treatment.

Results
Fifty-five patients were enrolled; 36 received ≥ 1 dose of trial medication (regimen M, n = 20, regimen U, n = 16). Afatinib was discontinued by all patients during the study. Reasons for afatinib discontinuation (regimen M/U) included disease progression (45%/50%), dose-limiting toxicity (10%/0%), and other adverse events (AEs; 35%/38%). The most frequently reported AEs with either regimen were diarrhea and rash, with no new safety signals identified. The MTD was determined as afatinib 30 mg in combination with daily TMZ and RT, and afatinib 40 mg in combination with RT alone.

Conclusions
This study identified the MTD for afatinib in combination with RT, with and without TMZ, in patients with GBM. Further studies of afatinib in patients with GBM are warranted and should be based on appropriate biomarker-based preselection.

Trial registration
NCT00977431 (first posted September 15, 2009).
Morphology, morphometry and some aspects of clinical anatomy in the skull and mandible of Sharri sheep
Authors: Jashari Tefik , Duro Sokol , Gündemir Ozan , Szara Tomasz , Ilieski Vlatko , Mamuti Dashmir , Choudhary Om Prakash 
Published: November 2021

AbstractThe aim of this study was to investigate and record data on the morphometrical parameters of the skull and mandible in Sharri sheep. We have evaluated 34 skulls (24 females and 10 males) of Sharri sheep (Ovis aries), a local breed of sheep from Northern Macedonia. Fifty-one measurements were evaluated in total: 37 parameters on the skull and 14 parameters on the mandible. The results of the study show that, in general, the morphology and morphometric parameters of the skull and mandible, of Sharri sheep are similar to those of other sheep breeds with few differences. The mean skull length (SL), skull height (SH), distance between two supraorbital foramina (DBTSF), orbital length (OL), mandible length (ML) and Sharri sheep diastema (D) were 247.47 ± 13.12 mm, 104.71 ± 6.21 mm, 50.73 ± 3.44 mm, 41.21 ± 1.99 mm, 185.91 ± 13.33 mm and 45.81 ± 3.73 mm, respectively. The results also show that out of 51 parameters, only 13 show a statistically significant difference between females and males, particularly the distance of akrokranion to opisthion (AO), articular surface length of mandibular condyle (ASL) and anterior limit of the mandibular foramen to cranial border of ramus mandible (RBMFRMRM). The findings of this study are important in many aspects: morphologically, morphometrically and especially clinically, during surgical interventions in the head region. With a lack of information in current literature on the investigated parameters in this sheep breed, the present data are a solid basis for further studies in comparative anatomy with other ruminants and in other areas such as zooarchaeology and animal welfare.
Antecedents to cognitive business model evaluation: a dynamic managerial capabilities perspective
Authors: Heubeck Tim , Meckl Reinhard 
Published: November 2021

AbstractThe increasing misalignment between the technological and economic domains in today’s digitalized global economy puts managers under constant pressure to redesign firms’ business models. Business model innovation has thus become a critical managerial challenge to develop and sustain competitive advantages. Building on the dynamic managerial capabilities perspective, we argue that managers are at the heart of strategic change through business model innovation. We hypothesize that decision-making regarding business model innovation is the outcome of how managers cognitively process information. We further reason that while managerial human capital and social capital reinforce each other, they also promote managers’ ability to consciously evaluate options for business model innovation. Our empirical study builds on a sample of firms operating primarily within the Industry 4.0 sector. The results significantly confirm managerial human and social capital as two crucial antecedents to cognitive business model innovation. Contrary to the literature, the data set does not show a significant positive relationship between managerial human and social capital. Our main contributions to the literature are twofold; from a methodological perspective, we are one of the first to construct a multidimensional measurement of dynamic managerial capabilities, while from a theoretical and practical perspective, our findings further underline the relevance of dynamic managerial capabilities for business model innovation. Finally, we discuss theoretical and practical implications and propose future avenues for research.
Exposure to negative acts at work and self-labelling as a victim of workplace bullying: The role of prior victimization from bullying
Authors: Hoprekstad Øystein Løvik , Hetland Jørn , Einarsen Ståle Valvatne 
Published: November 2021

AbstractThe present study examines employees’ prior victimization from bullying in school or at work as a predictor of 1) their current exposure to negative social acts at work and 2) the likelihood of labelling as a victim of workplace bullying, and 3) whether the link between exposure to negative acts at work and the perception of being bullied is stronger among those who have been bullied in the past. We tested our hypotheses using a probability sample of the Norwegian working population in a prospective design with a 5-year time lag (N = 1228). As hypothesized, prior victimization positively predicted subsequent exposure to negative acts, which in turn was related to a higher likelihood of developing a perception of being a victim of workplace bullying. However, contrary to our expectations, prior victimization from bullying did not affect the relationship between current exposure to negative acts at work and the likelihood of self-labelling as a victim. Taken together, the results suggest that employees’ prior victimization is a risk factor for future victimization, yet overall plays a rather modest role in understanding current exposure to negative acts and self-labelled victimization from bullying at work.
Cost–benefit analysis of beach-cast harvest: Closing land-marine nutrient loops in the Baltic Sea region
Authors: Söderqvist Tore , Nathaniel Hanna , Franzén Daniel , Franzén Frida , Hasselström Linus , Gröndahl Fredrik , Sinha Rajib , Stadmark Johanna , Strand Åsa , Ingmansson Ida , Lingegård Sofia , Thomas Jean-Baptiste 
Published: November 2021

AbstractHarvesting beach-cast can help mitigate marine eutrophication by closing land-marine nutrient loops and provide a blue biomass raw material for the bioeconomy. Cost–benefit analysis was applied to harvest activities during 2009–2018 on the island of Gotland in the Baltic Sea, highlighting benefits such as nutrient removal from the marine system and improved recreational opportunities as well as costs of using inputs necessary for harvest. The results indicate that the activities entailed a net gain to society, lending substance to continued funding for harvests on Gotland and assessments of upscaling of harvest activities to other areas in Sweden and elsewhere. The lessons learnt from the considerable harvest experience on Gotland should be utilized for developing concrete guidelines for carrying out sustainable harvest practice, paying due attention to local conditions but also to what can be generalized to a wider national and international context.
The effect of a lack of uncapped brood on social interactions between honey bee workers and the queen
Authors: Łopuch Sylwia , Tofilski Adam 
Published: November 2021

AbstractVibro-acoustic communication is used by honey bees in many different social contexts. Our previous research showed that workers interact with their queen outside of the swarming period by means of wing-beating behaviour. Therefore, the aim of this study was to verify the hypothesis that the wing-beating behaviour of workers attending the queen stimulates her to lay eggs. The behaviour of workers and the queen was recorded using a high-speed camera, at first in the presence of uncapped brood in the nest and then without one. None of the queens performed wing-beating behaviour. On the other hand, the workers attending the queen demonstrated this behaviour two times per minute, on average, even in the presence of uncapped brood in the nest. After removing the combs with the uncapped brood, the incidence of wing-beating behaviour increased significantly to an average of four times per minute. Wing-beating behaviour did not differ significantly in its characteristics when uncapped brood was present or absent in the nest. During 3 days after removing the combs with the uncapped brood, there was no significant increase in the rate of egg lying by the queen. Therefore, the results presented here do not convincingly confirm that the wing-beating behaviour of workers affects the rate of queen's egg-lying. This negative result can be related to colony disturbance and longer time required by the queen to increase egg production.
Philia: the biological foundations of Aristotle’s ethics
Authors: Torres Jorge 
Published: November 2021

AbstractThis article is the first one to offer an investigation, from a biological perspective, of “naturalphilia” or “kin-based”philia(commonly translated as “friendship”) in Aristotle’s practical philosophy. After some preliminary considerations about its place in Aristotle’s ethical treatises, the discussion focuses on Aristotle’s biology. Here we learn that naturalphilia, couched in terms of a biologicalpraxisrather than a trait of character, is widespread in the animal kingdom, although in different ways and to varying degrees. To account for such differences, Aristotle establishes aScala Philiaein two different biological texts—Historia AnimaliumandGeneration of Animals—where natural bonds in animals are classified in view of their strength and duration. Each level of Aristotle’sScalais examined. Finally, the argument returns to Aristotle’s ethical and political texts, drawing greater attention to the biological mechanisms that underlie naturalphiliain human beings. I conclude that naturalphiliaprovides one fundamental biological building-block of Aristotle’s ethics and politics.
Mikrobiomanalysen: Welchen Sinn haben sie für die Praxis?
Authors: Gorkiewicz Gregor 
Published: November 2021

ZusammenfassungDas Mikrobiom ist ein essenzieller Faktor für die Gesunderhaltung des Menschen, aber auch in der Krankheitsentstehung involviert. Bei vielen Erkrankungen können Mikrobiomveränderungen festgestellt werden, der klare Beweis einer Krankheitskausalität dieser Veränderungen mit den Erkrankungen fehlt aber zumeist. In letzter Zeit werden kommerziell angebotene Mikrobiomanalysen immer populärer und Mediziner*Innen sehen sich zusehends mit diesen „Befunden“ konfrontiert, die oftmals in Eigenregie von ihren Patienten durchgeführt werden. Es stellt sich die Frage, inwieweit diese „Ergebnisse“ einen medizinischen Nutzen für den individuellen Patienten darstellen. In der vorliegenden Übersichtsarbeit wird das derzeitige Wissen über Prinzipien und die Wertigkeit dieser Analysen zusammengefasst und ein Ausblick in die Zukunft von Mikrobiomanalysen als ein Teil einer individualisierten Medizin gegeben.
Extending assistive devices: using the existing interface versus using a new interface
Authors: Yuviler-Gavish Nirit , Kribu Eitan , Weiss Avi , Ben-Hanan Uri 
Published: November 2021

AbstractThe current research examined whether or not the interface of an extender attached to an assistive device should be identical to the interface of the assistive device. Given the profile of assistive devices such as wheelchairs and the need to extend them in special cases such when maneuvering over rough terrain or obstacles such as stairs and steep inclines, the interface design of these extenders (attached to existing assistive devices) should be evaluated. We have simulated a carrying platform for a wheelchair that is larger than the user’s regular wheelchair. We have examined whether participants used to handling their wheelchair, when asked to operate the carrying platform, handle the latter’s interface better or worse than their wheelchair’s interface. Participants (61) were assigned to one of two between-participants groups. Both groups were trained to navigate a wheelchair using the wheelchair’s interface and then operated the carrying platform. The Familiar Interface group navigated the carrying platform using the wheelchair’s interface, and the New Interface group navigated it with a new interface. The results demonstrated that the Familiar Interface group took longer to perform the task and collided more often with obstacles, compared to the New Interface group. The greater number of collisions can be linked directly to an erroneous mental model of the carrying platform’s size. The insights we reach can be linked to both extenders attached to an assistive device and other technological extenders.
Neighborhood racial composition, income, and distance to grocery retailers in Seattle
Authors: Ware Brandon O. , Amin Modhurima Dey , Jessup Eric L. , McCluskey Jill J. 
Published: November 2021

AbstractThis article examines whether racial disparities exist in travel distances and travel times to grocery stores in Seattle, WA. In contrast to the findings of studies conducted in other metropolitan cities, Seattle, WA, has few food deserts. We find that disparities in travel distance and travel time to supermarkets vary with the percentage of specific racial and ethnic populations. Greater Asian populations in a census tract are associated with shorter travel distance to the grocery, low income, and low vehicle access. For the Hispanic population, a greater percentage in a census tract increases the predicted travel distances and travel times to grocery stores. Greater income in tracts with more Hispanic population is associated with a shorter distance, and those tracts with more Asian population are associated with a longer distance, possibly due to cultural differences in diet.
Masculine Power? A Gendered Look at the Frontispiece of Hobbes'sLeviathan
Authors: Boucher Joanne 
Published: November 2021

AbstractThe frontispiece of Hobbes'sLeviathanis justly renowned as a powerful visual advertisement for his political philosophy. Consequently, its rich imagery has been the subject of extensive scholarly commentary. Surprisingly, then, its gendered dimensions have received relatively limited attention. This essay explores this neglected facet of the frontispiece. I argue that the image initially appears to present a hypermasculine sovereign. However, upon closer inspection, and considered alongside Hobbes's economic theory, it yields to a reading of the sovereign as an ambiguously gendered figure. Reading the frontispiece through the prism of gender and the economy reveals not a static image of unwavering male power but rather one of an equivocally-sexed creature teeming with life, contradictions, and complexities worthy of continued examination.
Societal activities associated with SARS-CoV-2 infection: a case-control study in Denmark, November 2020
Authors: Munch Pernille Kold , Espenhain Laura , Hansen Christian Holm , Müller Luise , Krause Tyra Grove , Ethelberg Steen 
Published: November 2021

Abstract
Identification of societal activities associated with SARS-CoV-2 infection may provide an evidence base for implementing preventive measures. Here, we investigated potential determinants for infection in Denmark in a situation where society was only partially open. We conducted a national matched case-control study. Cases were recent RT-PCR test-positives, while controls, individually matched on age, sex and residence, had not previously tested positive for SARS-CoV-2. Questions concerned person contact and community exposures. Telephone interviews were performed over a 7-day period in December 2020. We included 300 cases and 317 controls and determined odds ratios (ORs) and 95% confidence intervals (95% CI) by conditional logistical regression with adjustment for household size and country of origin. Contact (OR 4.9, 95% CI 2.4–10) and close contact (OR 13, 95% CI 6.7–25) with a person with a known SARS-CoV-2 infection were main determinants. Contact most often took place in the household or work place. Community determinants included events with singing (OR 2.1, 95% CI 1.1–4.1), attending fitness centres (OR 1.8, 95% CI 1.1–2.8) and consumption of alcohol in a bar (OR 10, 95% CI 1.5–65). Other community exposures appeared not to be associated with infection, these included shopping at supermarkets, travel by public transport, dining at restaurants and private social events with few participants. Overall, the restrictions in place at the time of the study appeared to be sufficient to reduce transmission of disease in the public space, which instead largely took place following direct exposures to people with known SARS-CoV-2 infections.
New coaxial low-pass filters with ultra-wide and spurious free stopband
Authors: Goulouev Rousslan , McLaren Colin , Padilla Pardo Marta 
Published: November 2021

AbstractModern space communication systems often need high-power low-frequency (UHF, L-, S-, and C-band) low-pass filters (LPFs) with wide stopbands extending to Ka-band and beyond. Current design approaches frequently fail to meet these requirements completely. This paper proposes a new coaxial LPF concept and design methodology. The LPF consists of an array of cavity elements, which operate with transverse electromagnetic mode (TEM) and transverse magnetic (TM)-coupled resonances, and thus achieve a frequency response with a reflection zero at DC and transmission zeroes at targeted stopband locations. The design method is based on positioning the cavities in a quasi-periodic order, which efficiently spreads the transmission zeroes over the stopband, while keeping the characteristic impedance matched to the input/output interfaces over the passband. This design concept yields an ultra-wide, continuous and modal spurious-free stopband, while maintaining a low insertion loss, high peak power capacity, and low sensitivity to production tolerances.
Exceptionally High Emplacement Rate of the Afar Mantle Plume Head
Authors: Eid B. , Lhuillier F. , Gilder S. A. , Pfänder J. A. , Gebru E. F. , Aßbichler D. 
Published: November 2021

AbstractWe investigated a 1‐km‐thick sequence of lava flows that erupted over the Afar plume axis in order to better understand the emplacement history of the ∼30 Ma Ethiopia‐Yemen Traps. Geochemical analyses reveal high‐titanium concentrations (TiO2 3.9 ± 0.5 wt%) in basalts close to picritic compositions. Indistinguishable 40Ar/39Ar ages throughout the section define a weighted‐mean of 31.18 ± 0.28 Ma (95% confidence). This date, together with solely normal polarity magnetization directions in 68 geomagnetically independent horizons, constrain the eruption to within chron C12n, with a maximum duration of a few hundreds of kyr for the entire 1‐km‐thick section. The rate of geomagnetic secular variation used as a chronometer refines the duration to only a few tens of kyr, leading to a local extrusion rate of 4–13 km3/yr for the Afar plume head, which greatly exceeds the average rate of 0.3–1.2 km3/yr for the entire Ethiopia‐Yemen Traps.
The Interplay Between Seismic and Aseismic Slip Along the Chaman Fault Illuminated by InSAR
Authors: Dalaison M. , Jolivet R. , van Rijsingen E. M. , Michel S. 
Published: November 2021

AbstractThe 700‐km‐long Chaman fault (CF) marks the western edge of the plate boundary between India and Eurasia. Although global plate models predict 2.3–3.6 cm/yr left‐lateral motion between both plates, the fault is known to have hosted few earthquakes in historical times. Recent geodetic measurements attested the presence of aseismic slip locally. To detail the interplay between fast and slow slip along the CF, we build three Interferometric Synthetic‐Aperture Radar time series of ground deformation covering the whole fault length over 5 years (2014–2019). We find that most of the active fault trace slips aseismically and continuously. From south to north, we identify three creeping fault portions: the Nushki, Central, and Qalat segments of lengths between 80 and 130 km. The loading rate is 1.2 ± 0.3 cm/yr for the two southernmost portions, while it is about 0.7 ± 0.2 cm/yr for the Qalat segment. The Central segment and the nearby locked segments have hosted the largest known historical earthquakes on the CF, and three moderate magnitude earthquakes in our observation period. We image these earthquakes for which modeled slip at depth (Mw5–5.6), time series of surface slip and deformation patterns argue toward large triggered aseismic slip. The June 2018 event displays postseismic moment 3–15 times greater than coseismic moment. Over the two decades covered by geodetic observations, continuous or triggered aseismic slip dominates along most of the fault and co‐locates with earthquakes. We observe that fault geometrical complexities delimit active segments and may be responsible for the kilometer‐scale intertwining between seismic and aseismic events.
Organic Matter Accretion, Shallow Subsidence, and River Delta Sustainability
Authors: Keogh Molly E. , Törnqvist Torbjörn E. , Kolker Alexander S. , Erkens Gilles , Bridgeman Jonathan G. 
Published: November 2021

AbstractGlobally, mineral sediment supply to deltaic wetlands has generally decreased so these wetlands increasingly rely on accretion of organic matter to keep pace with relative sea‐level rise (RSLR). Because organic‐rich sediments tend to be more compressible than mineral‐dominated sediments, deltaic wetland strata are vulnerable to compaction and drowning. Using an unprecedented data set of almost 3,000 discrete bulk density and organic‐matter measurements, we examine organic‐rich facies from coastal Louisiana to quantify the thickness lost to compaction and investigate whether sediments are able to maintain sufficient volume for the associated wetlands to keep pace with RSLR. We find that organic content as well as overburden thickness and density (which together determine effective stress) strongly control sediment compaction. Most compaction occurs in the top 1–3 m and within the first 100–500 years after deposition. In settings with thick peat beds, successions up to 14 m thick have been compacted by up to ∼50%. We apply geotechnical modeling to examine the balance between elevation gained from accretion and elevation lost to compaction due to renewed sediment deposition over a 100‐year timescale. Wetlands overlying mineral‐dominated lithologies may support the weight of deposition and allow net elevation gain. Model results show that reintroduction of sediment to a representative Mississippi Delta wetland site will likely cause another ∼0.35–1.14 m of compaction but leave a net elevation gain of ∼0.01–1.75 m, depending on the sediment delivery rate and stiffness of underlying strata.