bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Program to Improve Cognitive Function in Individuals With Dementia Using Transcranial Alternating Current Stimulation (tACS) and Tutored Cognitive Exercises
Authors: Moussavi Zahra , Kimura Kazushige , Kehler Lonnie , de Oliveira Francisco Cristina , Lithgow Brian 
Published: March 2021

The effects of cognitive exercises on the healthy aging population is controversial. Transcranial alternating current stimulation (tACS) is considered a promising tool for modulating brain oscillation. Research is lacking on its long-lasting cognitive/therapeutic effect. This is the first pilot study to explore the effect of a regimen of cognitive exercises with and without tACS on older adults with dementia. The study groups were 28 individuals (age 56–83 years) enrolled into two groups: Exr Group, who received cognitive exercises only and the Exr + tACS Group who received tACS at 40 Hz simultaneously with cognitive exercises for a period of 4 consecutive weeks, 5 days/week, two 30 min-sessions/day; all the training sessions were tutored. The cognitive exercises were applied using the MindTriggers app. They were assessed at pre and post intervention and also one month after the end of trial (follow-up) with an independent assessment (WMS-IV) as the primary outcome measure. The results show significant cognitive improvement at post-intervention in both groups, while the Exr + tACS protocol lead to superior cognitive improvement at follow-up session. The most important outcomes of this study are: 1) The tutored repeated practice of the MindTriggers app exercises does significantly improve the cognitive functions of older adults with dementia and that that improvement lasts for at least one month after the end of the intervention, and 2) The application of tACS increases the positive effects of cognitive exercises with the positive effect lasting an even longer period of time than exercises alone; in other words we speculate that it may lead to long-term potentiation.
A Novel Anastomosis Technique for Laparoscopic Pancreaticoduodenectomy: Case Series of Our Center's Experience
Authors: Sun Pi-Jiang , Yu Yan-Hua , Li Jian-Wei , Cui Xi-Jun 
Published: March 2021

Background: Laparoscopic pancreaticoduodenectomy has developed rapidly in recent years. Postoperative pancreatic fistula is still the most dangerous complication of laparoscopic pancreaticoduodenectomy. Baumgart pancreaticojejunostomy is considered one of the safest anastomosis procedures, with low rates of pancreatic fistula. We modified Blumgart pancreaticojejunostomy and applied the modified procedure during laparoscopic pancreaticoduodenectomy. The modified procedure entailed a longitudinal U-shaped suture through the pancreas for anastomosis of the pancreatic duct and the jejunal mucosa.Methods: We prospectively collected and retrospectively analyzed the data of 120 patients who underwent laparoscopic pancreaticoduodenectomy from January 2016. The total operative time, time for complete pancreaticojejunostomy, postoperative pancreatic fistula rate, postoperative delayed gastric emptying, postoperative bleeding, postoperative length of hospital stays, and mortality within 90 days after surgery were analyzed. An analysis of laparoscopic pancreaticojejunostomy compared with open pancreaticojejunostomy is also reported.Results: In the laparoscopic pancreaticojejunostomy group, the average total operative time, the average time for complete pancreaticojejunostomy, and the average intraoperative blood loss were 271 min, 35.3 min, and 184 ml, respectively. The total postoperative clinically relevant pancreatic fistula rate was 9.2% (Grade B and C fistulas). The incidence rates of postoperative delayed gastric emptying and postoperative biliary fistula were ~2.5 and 1.7%, respectively. The postoperative bleeding rate was 0.83%, and the average postoperative indwelling time of the abdominal drainage tube was 7.3 days. The postoperative length of hospital stay was 10.8 days, and the mortality rate within 90 days after surgery was 0.83%. The rates of clinically relevant postoperative clinically relevant pancreatic fistula are comparable between laparoscopic and open surgery, there were no other severe postoperative complications in either group. The mean postoperative length of hospital stay was significantly shorter in the laparoscopic pancreaticojejunostomy group.Conclusion: The modified laparoscopic-adapted Blumgart anastomosis simplifies and facilitates the creation of the pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy. The rates of clinically relevant postoperative pancreatic fistula are comparable with those obtained by open surgery, and length of stay are shoter.
Language Learning Strategies Used in English Writing by Thai Undergraduate Students
Authors: Pongsukvajchakul Patsara 
Published: March 2021

This research investigated language learning strategies used in English writing by 100 Thai undergraduate students. It analyzed differences in the use of language learning strategies in English writing in the second semester of the 2019 academic year at Kasetsart University in Chonburi, Thailand. The research instrument was a 50-item questionnaire adapted from Oxford’s strategy inventory for language learning (SILL). Data on language learning strategies used in English writing were examined using descriptive statistics (mean, frequency, percentage and standard deviation). Differences in the use of language learning strategies in English writing were analyzed by t-test and F-test. The results indicated that primarily, students used social strategies, followed by memory strategies, compensatory strategies, metacognitive strategies, cognitive strategies and affective strategies in English writing, respectively. Significant differences in the use of language learning strategies in English writing were found on students’ field of study, year of study and writing frequency, except gender, age and English point.
Psychological Well-being of Senior Secondary School Students in Relation to Gender and Academic Achievement: An Empirical Study
Authors: Bhat Bilal Ahmad 
Published: March 2021

India, one of the fast growing and developing nations of the world, is doing well in growth, but it is not up to the mark in some fields. In science and technology, it is doing at par with other developed nations, and markable achievements are being touched. But in health or human growth, most of the population is not clear about the importance of health and human potentials. Many portions of the population are not aware of the positive aspects of human beings that can help them to flourish. The study has been done to find the psychological well-being of academic achievement and gender. For the study, a sample of 519 senior secondary school students from different senior secondary schools of Kulgam and Anantnag districts of Kashmir valley were selected. The sample was drawn by using a multi-stage stratified sampling technique. The tools of data collection were Psychological Well-Being Scale (PWBS) developed by Dr. Devendra Singh Sisodia and Ms. Pooja Choudhary (2012) and academic achievement as the marks obtained by senior secondary school students in the board examination conducted by JKBOSE. The data obtained from these students were then analyzed using appropriate statistical techniques with the help of SPSS version 22. The paper also makes some suggestions, keeping the findings of the study in mind to enhance the psychological well-being of our budding human resource.
PELATIHAN DAN PENDAMPINGAN APLIKASI PAYET PADA PRODUK KULIT KAYU NYAMU DAN ROTAN DI KELOMPOK PERAJIN
Authors: Nursiah Nursiah Nursiah , Tanduh Yusintha Tanduh , Rahmawati Reni Rahmawati , Yamani Zaki Yamani 
Published: March 2021

Abstract: Nyamu and Rattan bark by the people of Central Kalimantan in general are only used for binding, making traditional clothes that are used in certain events only. Even though there are still many things that can be made from this Nyamu leather raw material, such as alternative materials for making longsongan bags, modified into bags or wallets which can then be further developed in terms of design. To increase the value of beauty and increase the value of handicraft products made from Nyamu bark such as bags and wallets, it is carried out by means of unified matching sequins as a way to enhance the appearance of the products produced and become a special feature of this Nyamu bark product. PKW which is motivated by the assistance of partners in empowering the community in this activity will provide Training and Assistance in the Black and White Craftsmen Group. The method used is active participatory community empowerment through collaboration with partners namely the transfer of knowledge and technology through training activities. All PKW activities went smoothly according to plan. The partner is able to practice what is involved in the activity and has already produced a bag and wallet product with modified sequins. Based on the results of monitoring and evaluation, around 70% of participants succeeded in sewing wallets and purses, while 90% of participants had already started to be skilled at making various patterns of sequin paintings, and several products were sold.
.Keywords: Nyamu bark, rattan, sequin, craftsman.
Pharmacoeconomic analysis of the choice of antimicrobial drugs for the treatment of community-acquired pneumonia by physicians and final year medical students
Authors: Deriushkin V. G. , Gatsura S. V. 
Published: March 2021

The authors of the article conduct a pharmacoeconomic analysis of antimicrobial agents (AMA) prescriptions based on a survey of graduates of the medical faculty of a medical university and outpatient healthcare practitioners in Moscow. In addition to the pharmacoepidemiological part, the article also contains a pharmacoeconomic aspect to obtain a more complete picture, reflecting the choice of drugs not only in primary healthcare, but also among graduates of the medical faculty, who can potentially become its members without preliminary training in medical residency.The purpose of this study is to conduct a comparative pharmacoeconomic analysis of the AMA choice in the treatment of community-acquired pneumonia based on the data of a survey of general practitioners, district physicians and graduates of the medical faculty.Methodology. The 206 physicians took part in the anonymous voluntary survey.Results. 177 (85.9 %) of surveyed doctors were women and 62 (14.1 %) were men who made up Group 1. The average age of the surveyed doctors was 47.8±13.3 years, the average medical experience was 21.4±13.4 years. Group 2 consisted of 240 students, of which 178 were women (74.17 %) and 62 were men (25.83 %). The average age of the respondents in the group 2 was 24.8±3.3 years. When calculating the average cost of a treatment course of community-acquired pneumonia, depending on the structure of prescriptions, the value in Group 1 amounted to 420.82 rubles and 367.44 rubles in Group 2, while the share of costs for aminopenicillin drugs directly recommended for prescription to treat community-acquired pneumonia amounted to 8.35 and 4.97 %, respectively. Despite the current recommendations, respondents prefer to choose second-line AMAs, which are more expensive drugs. Respondents in both groups underestimate the first-line drugs that meet the current recommendations, namely aminopenicillins. Despite their low cost and ease of use in an outpatient setting, the frequency of their prescription remains low. The authors believe that more attention should be paid to the problem of rational use of antimicrobial agents. This problem can be solved through educational interventions at all levels of education, which can change the picture of drugs prescriptions in future, will allow practitioners and graduates of medical faculties to refer more often to clinical guidelines and patient treatment protocols. Comprehensive measures in this direction can not only positively affect the quality of medical care, but also reduce antibiotic resistance in the outpatient setting.
Unrealistic Optimism, Compulsive Purchasing and Debt-Stress among Credit Card Users in Sri Lanka
Authors: Rodrigo G. M. R. , Galdolage B. S. 
Published: March 2021

Credit cards become increasingly popular in Sri Lanka while a total of 78,201 new issues were in 2019 first quarter (Central Bank report). Credit card usage affects the consumption patterns of people, sometimes leading to purchase excessively with impractical confidence (Omar, et al., 2013). According to the central bank report, around total of 118,905 cards are being defaulted where the payment is in arrears for 90days or more in 2019 showing an increment in credit card debts, which may result in stress among card users. In view of the timeliness and relevance of this issue, this study aims to investigate the impact of unrealistic optimism and compulsive purchasing on debt-stress among credit card users in Sri Lanka. This study employs the quantitative approach in collecting data using self-administered questionnaires among 301 credit cardholders in Western Province, Sri Lanka who were chosen based on the non-probabilistic convenience sampling method. This study found a moderate positive impact of both the unrealistic optimism and compulsive purchasing on debt stress. Further, a moderate positive correlation was found between unrealistic optimism and compulsive purchasing too. This research contributes to fill the gap in the extant literature by broadening the understanding on concepts such as unrealistic optimism, compulsive purchasing, and debt stress which is prevalent among credit card users. Further, as managerial implications, this study provides a better understanding on cardholders in Sri Lanka which might be a good reference for banks, card service providers and investors in developing their policies. Further, it will support the business sector to develop the Sri Lankan non-cash payment market while policymakers and tax authorities can understand the causes of high credit card debts.
Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish
Authors: Chen Weijie , Zhao Jingjing , Mu Di , Wang Zhuang , Liu Qin , Zhang Yuanxing , Yang Dahai 
Published: March 2021

Abstract
The formation of neutrophil extracellular trap (NET) is a critical host defense when neutrophils migrate to infection sites. Pyroptosis is a newly identified programmed cell death, which is tightly regulated by inflammasome activation. However, the mechanism of pyroptotic signaling participating in NET production remains to be elucidated. In this study, the zebrafish larvae otic vesicle microinjection model was used to infect larvae with hemolysin-overexpressing Edwardsiella piscicida (EthA+), and a rapid migration of neutrophils to infection sites was observed. Intriguingly, EthA+ infection effectively induced significant neutrophil membrane rupture in vivo, which was dependent on caspase-B (caspy2) and gasdermin Eb (GSDMEb) but not caspase-A or gasdermin Ea. Specifically, the EthA+ E. piscicida infection induced pyroptosis along with NETosis in vitro, and depletion of either caspy2 or GSDMEb impaired NET formation in vivo. Consequently, inhibition of the caspy2–GSDMEb axis-gated NETosis impaired bacterial clearance in vivo. Altogether, these data provide evidence that teleost fish innate immune cells, including neutrophils, express features of pyroptosis that are critical for NETosis in teleost innate immunity.
Translational relevance of baseline peripheral blood biomarkers to assess the efficacy of anti-programmed cell death 1 use in solid malignancies
Authors: Varayathu Hrishi , Sarathy Vinu , Thomas Beulah Elsa , Mufti Suhail Sayeed , Sangi Lalram , Thungappa Satheesh Chiradoni , Tripathi Priyank , Naik Radheshyam 
Published: March 2021

Background:
This study is an overall clinical analysis of anti-programmed cell death 1 (PD1) antibodies used in a single institution, emphasizing the role of baseline peripheral blood markers as a prognostic or predictor biomarker of immunotherapy.

Methods:
Sixty-one patients were retrospectively analyzed from hospital medical records. The endpoint of this study was death from any cause and the survival time was calculated from the date of start of immunotherapy to the date of death. Descriptive and survival statistics was performed using SPSS version 23. Cutoff values for baseline biomarkers (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], neutrophil-to-eosinophil ratio [NER], and lymphocyte-to-monocyte ratio [LMR]) were obtained using cutp function of Evaluate Cutpoints software (R survMisc package). Pearson and Pearman correlation coefficients were used to examine the relationship of peripheral blood biomarkers.

Results:
Nighty-eight percent of the study population had Stage IV disease and total median overall survival postanti-PD1 therapy was 10.7 months. Patients receiving more than 5 doses of anti-PD1 therapy (12.6 m vs. 4.4 m, P < 0.001) and used in front lines (18.9 m vs. 10.7 m vs. 10.1 m vs. 2.8 m in first line, second line, third line, and >3 lines, respectively, P = 0.049) were found to have an impact in overall survival. Pembrolizumab showed a better survival compared to nivolumab (17.4 m vs. 8.2 m, P = 0.049) in our study. Among baseline biomarkers assessed, NLR (cutoff − 2.81, P = 0.003) and LMR (cutoff – 5.76, P = 0.017) has shown a statistically significant relationship with immunotherapy response. NER (cutoff − 24.32, P = 0.051) and PLR (cutoff – 190.8, P = 0.072) were also found to exhibit a strong relationship with anti-PD1 therapy response. NLR exhibits a statistically significant positive correlation with PLR (r = 0.917 P < 0.001) and NER (r = 0.400 P = 0.014).

Conclusion:
Real-life data analysis of anti-PD1 use for solid cancers highlights that baseline NLR, PLR, NER, and LMR have a significant role as immunotherapy biomarkers. However, larger studies are required to further prove the specificity and sensitivity.
Diversidad de aves de los bosques montanos en el departamento del Cusco
Authors: Jara-Moscoso Norma , Aguilar-Condemayta Olintho , Ayma-Cornejo Luis , Vargas-Serrano Karina , Mejía-Espinoza Karol , Olivera-Aguirre Daniela S. , Ochoa Jose Antonio 
Published: March 2021

Se presenta un estudio de la diversidad de aves de bosques montanos en el departamento del Cusco basado en revisión de colecciones de Museo y bibliografía. 671 especies de aves fueron registradas en total para los bosques montanos de Cusco ubicados entre los 700 a 3800 m de altitud: 584 especies para el Parque Nacional del Manu, 325 para Machupicchu, 150 para Choquequirao, 131 para Yanatile y 190 para el valle de Marcapata. El grado de similitud de Jaccard para todos los casos fue menor al 50%. A pesar que existe varias investigaciones en el Manu y Machupicchu, existen vacíos de información en la diversidad de aves en los valles de Marcapata, Yanatile, Umasbamba, la cuenca media del río Urubamba, y Choquequirao.
Caracterizacion de la diversidad citogenetica de Physalis peruviana L. (aguaymanto) en dos ecotipos
Authors: Cjuno H. Olga L. , Madera T. Elena E. , Rosas A. M. Lourdes , Zegarra P. Luz M. , Mariaca V. Concepción 
Published: March 2021

Physalis peruviana L (aguaymanto), es una solanácea, herbácea perenne, de crecimiento rápido, se distribuye desde los 1500 a 3000m de altitud, se desarrolla entre 15-20°C, característico por su gran importancia nutricional y terapéutica (anticancérigeno, antipirético e inmunomodulador) de crecimiento rápido, en terrenos bien o mal drenados con escasa demanda de nitrógeno. En el estudio se caracterizó el cariotipo de dos ecotipos de Physalis peruviana L, uno proveniente del gemoplasma de K´ayra (Cusco) y semillas del ecotipo Huayoccari (Urubamba), las semillas en estudio alcanzaron entre 18 y 21 días de rizogénesis, a partir de las cuales se realizaron, pretratamiento, hidrólisis y coloración de meristemos. Se determinó niveles de ploidía de 2n=24 para el ecotipo K´ayra y 2n=36 para el ecotipo Huayoccari, la dotación cromosómica metacéntrica fue agrupada en 3 grupos: Grupo A: pares 1,2,4,5,y 7, Grupo B: pares 3,6,8,9, y 10, Grupo C: pares 11 y 12, de acuerdo a la clasificación de Levan, 1964. Los ecotipos exhibieron variación citogenética, lo que se atribuiría al proceso evolutivo de la especie.
GAMBARAN TINGKAT DEPRESI PADA REMAJA YANG AKTIF BERORGANISASI DI SMK PGRI 1 BANYUWANGI
Authors: Dewi Gayatri Rahma 
Published: March 2021

ABSTRACTDepression is a feeling of emptiness and sadness that leads to decreased interest in happy activities, resting and eating irregularly, decreased concentration, guilt to yourself, and the emergence of suicidal thoughts. Adolescence is a transitional phase of children's life and adult life can be seen from the growth and development of the body's biological and psychological. Adolescents in Indonesia aged at 15-19 years experience moderate depressive symptoms reaching 22% and severe depression symptoms reaching 7.2%. The purpose of this study was to see a picture of depression in adolescents at X vocational high school in Banyuwangi. This research method uses descriptive research with a quantitative approach. The level of adolescent depression at X vocational high school in Banyuwangi was measured using the Beck Depression Inventory-II. Results: 29.4% of adolescents had mild depression, 17.6% of adolescents had moderate depression, and 2% of adolescents had major depression. The conclusion of this study is depression in adolescents at X vocational high school in Banyuwangi has the highest level of minimal depressive symptoms. Severe depression that occurs in adolescents needs to be treated immediately so that it does not threaten their future.Keywords: Depression, Adolescent, Beck Depression Invetory-II
ABSTRAKDepresi adalah perasaan hampa dan sedih hingga menurunnya minat pada kegiatan yang membuat senang, istirahat dan makan tidak teratur, konsentrasi menurun, rasa bersalah dalam diri, dan munculnya keinginan untuk bunuh diri. Masa remaja adalah fase peralihan dari kehidupan anak-anak dan masa kehidupan orang dewasa dapat dilihat dari pertumbuhan dan perkembangan biologis pada tubuh dan psikologis. Remaja di Indonesia pada usia 15-19 tahun mengalami gejala depresi tingkat sedang mencapai 22% dan gejala depresi tingkat berat mencapai 7,2%. Tujuan dari penelitian ini untuk melihat gambaran tingkat depresi pada remaja yang aktif berorganisasi di Sekolah Menengah Kejuruan (SMK) X di Banyuwangi. Metode penelitian ini menggunakan penelitian deskriptif dengan pendekatan kuantitatif. Tingkatan depresi remaja di SMK X di Banyuwangi diukur menggunakan Beck Depression Inventory-II. Hasil dari penelitian menunjukan sebanyak 29,4% remaja mengalami depresi ringan, 17,6% remaja mengalami depresi sedang, dan 2% remaja mengalami depresi berat. Kesimpulan dari penelitian ini adalah depresi pada remaja SMK X di Banyuwangi memiliki tingkat gejala depresi minimal tertinggi. Depresi berat yang terjadi pada remaja perlu segera ditangani agar tidak mengancam masa depannya.Kata kunci: depresi, remaja, Beck Depression Invetory-II