bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning With Data Enhancement for the Differentiation of Solitary and Multiple Cerebral Glioblastoma, Lymphoma, and Tumefactive Demyelinating Lesion
Authors: Zhang Yu , Liang Kewei , He Jiaqi , Ma He , Chen Hongyan , Zheng Fei , Zhang Lingling , Wang Xinsheng , Ma Xibo , Chen Xuzhu 
Published: August 2021

ObjectivesTo explore the MRI-based differential diagnosis of deep learning with data enhancement for cerebral glioblastoma (GBM), primary central nervous system lymphoma (PCNSL), and tumefactive demyelinating lesion (TDL).Materials and MethodsThis retrospective study analyzed the MRI data of 261 patients with pathologically diagnosed solitary and multiple cerebral GBM (n = 97), PCNSL (n = 92), and TDL (n = 72). The 3D segmentation model was trained to capture the lesion. Different enhancement data were generated by changing the pixel ratio of the lesion and non-lesion areas. The 3D classification network was trained by using the enhancement data. The accuracy, sensitivity, specificity, and area under the curve (AUC) were used to assess the value of different enhancement data on the discrimination performance. These results were then compared with the neuroradiologists’ diagnoses.ResultsThe diagnostic performance fluctuated with the ratio of lesion to non-lesion area changed. The diagnostic performance was best when the ratio was 1.5. The AUCs of GBM, PCNSL, and TDL were 1.00 (95% confidence interval [CI]: 1.000–1.000), 0.96 (95% CI: 0.923–1.000), and 0.954 (95% CI: 0.904–1.000), respectively.ConclusionsDeep learning with data enhancement is useful for the accurate identification of GBM, PCNSL, and TDL, and its diagnostic performance is better than that of the neuroradiologists.
Rumination Syndrome in Children and Adolescents: A Mini Review
Authors: Martinez Marc , Rathod Sandeep , Friesen Hunter J. , Rosen John M. , Friesen Craig A. , Schurman Jennifer V. 
Published: August 2021

Introduction: Rumination syndrome involves recurrent regurgitation of food and is believed to be underdiagnosed with patients experiencing long delays in diagnosis. It can be associated with significant social consequences, high rates of school absenteeism, and medical complications such as weight loss. The primary aims of the current review are to assess the literature regarding prevalence, pathophysiology, and treatment outcomes with a focus on neurotypical children and adolescents.Results: Population studies in children/adolescents, 5 years of age or older, range from 0 to 5.1%. There are fewer studies in clinical settings, but the prevalence appears to be higher in patients with other gastrointestinal symptoms, particularly chronic vomiting. While physiologic changes that occur during a rumination episode are well-described, the underlying cause is less well-defined. In general, rumination appears to have similarities to other functional gastrointestinal disorders including dysmotility, possibly inflammation, and an interaction with psychologic function. While diaphragmatic breathing is considered the mainstay of treatment, pediatric data demonstrating efficacy is lacking, especially as an isolated treatment.Conclusion: Pediatric rumination syndrome remains greatly understudied, particularly regarding treatment. There is a need to better define prevalence in both the primary care and subspecialty clinical settings, especially in patients presenting with vomiting or apparent gastroesophageal reflux. There is a need to determine whether treatment of co-morbid conditions results in improvement of rumination. Diaphragmatic breathing needs to be studied and compared to other competing responses.
Rejuvenation of Helicobacter pylori–Associated Atrophic Gastritis Through Concerted Actions of Placenta-Derived Mesenchymal Stem Cells Prevented Gastric Cancer
Authors: Park Jong Min , Han Young Min , Hahm Ki Baik 
Published: August 2021

Chronic Helicobacter pylori infection causes gastric cancer via the progression of precancerous chronic atrophic gastritis (CAG). Therefore, repairing gastric atrophy could be a useful strategy in preventing H. pylori–associated gastric carcinogenesis. Although eradication of the bacterial pathogen offers one solution to this association, this study was designed to evaluate an alternative approach using mesenchymal stem cells to treat CAG and prevent carcinogenesis. Here, we used human placenta-derived mesenchymal stem cells (PD-MSCs) and their conditioned medium (CM) to treat H. pylori–associated CAG in a mice/cell model to explore their therapeutic effects and elucidate their molecular mechanisms. We compared the changes in the fecal microbiomes in response to PD-MSC treatments, and chronic H. pylori–infected mice were given ten treatments with PD-MSCs before being sacrificed for end point assays at around 36 weeks of age. These animals presented with significant reductions in the mean body weights of the control group, which were eradicated following PD-MSC treatment (p &lt; 0.01). Significant changes in various pathological parameters including inflammation, gastric atrophy, erosions/ulcers, and dysplastic changes were noted in the control group (p &lt; 0.01), but these were all significantly reduced in the PD-MSC/CM-treated groups. Lgr5+, Ki-67, H+/K+-ATPase, and Musashi-1 expressions were all significantly increased in the treated animals, while inflammatory mediators, MMP, and apoptotic executors were significantly decreased in the PD-MSC group compared to the control group (p &lt; 0.001). Our model showed that H. pylori–initiated, high-salt diet–promoted gastric atrophic gastritis resulted in significant changes in the fecal microbiome at the phylum/genus level and that PD-MSC/CM interventions facilitated a return to more normal microbial communities. In conclusion, administration of PD-MSCs or their conditioned medium may present a novel rejuvenating agent in preventing the progression of H. pylori–associated premalignant lesions.
Interventions for Preventing Cardiotoxicity in Breast Cancer Patients Receiving Trastuzumab: A Systemic Review and Bayesian Network Meta-Analysis
Authors: Li Xinyi , Wu Ziyang , Du Xin , Wu Yibo , Xie Xiaohui , Shi Luwen 
Published: August 2021

Background: Trastuzumab is associated with the risk of cardiotoxicity. Here, we aim to explore interventions for preventing trastuzumab-related cardiotoxic effects in breast cancer patients.Methods: A systematic review was performed including trials of breast cancer patients with intervention to prevent cardiotoxicity of trastuzumab. Trials were searched through databases including PubMed, Embase, and Cochrane Library.Results: Eight RCTs were included. Five trials reported the outcomes of short-duration interventions, including 6-month and 9-week durations, and only 9-week treatment has a significant difference from the 12-month group (OR 0.38; 95% CI 0.18–0.83) using cardiotoxicity as the outcome. However, 6-month treatment turned out to yield less occurrence of trastuzumab discontinuation (OR 0.32; 95% CI 0.24–0.42). Three trials reported interventions of cardioprotective drugs, and there is no significant difference shown in any cardioprotective group compared with placebo (cardiotoxicity outcome: angiotensin-converting enzyme inhibitor: OR 0.48; 95% CI 0.057–2.3; angiotensin receptor blocker: OR 1.3; 95% CI 0.12–14; β-blocker: OR 0.48; 95% CI 0.057–2.3; trastuzumab interruption outcome: angiotensin-converting enzyme inhibitor: OR 0.45; 95% CI 0.12–1.3; angiotensin receptor blocker: OR 0.87; 95% CI 0.15–4.8; β-blocker: OR 0.41; 95% CI 0.11–1.2).Conclusion: Only the 9-week group has a significant difference from the 12-month group using cardiotoxicity as the outcome. And 6-month treatment turned out to yield less occurrence of trastuzumab discontinuation. The use of cardioprotective drugs failed to prevent trastuzumab-related cardiotoxic effects in breast cancer patients.
The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease
Authors: Trindade Inês A. , Pereira Joana , Galhardo Ana , Ferreira Nuno B. , Lucena-Santos Paola , Carvalho Sérgio A. , Oliveira Sara , Skvarc David , Rocha Bárbara S. , Portela Francisco , Ferreira Cláudia 
Published: August 2021

Background:There is ample evidence of the high mental health burden caused by Inflammatory Bowel Disease (IBD). Several constructs such as experiential avoidance, cognitive fusion, shame, and self-criticism have recently emerged as potential intervention targets to improve mental health in IBD. Psychotherapeutic models such as Acceptance and Commitment Therapy and compassion-based interventions are known to target these constructs. In this protocol, we aim to describe a two-arm Randomized Controlled Trial (RCT) testing the efficacy of an ACT and compassion-focused intervention named Living with Intention, Fullness, and Engagement with Inflammatory Bowel Disease (LIFEwithIBD) intervention + Treatment As Usual (TAU) vs. TAU in improving psychological distress, quality of life, work and social functioning, IBD symptom perception, illness-related shame, psychological flexibility, self-compassion, disease activity, inflammation biomarkers, and gut microbiota diversity.Methods:This trial is registered atClinicalTrials.gov(Identifier: NCT03840707, date assigned 13/02/2019). The LIFEwithIBD intervention is an adaptation to the IBD population of the Mind programme for people with cancer, an acceptance, mindfulness, and compassion-based intervention designed to be delivered in a group format. The LIFEwithIBD intervention's structure and topics are presented in this protocol. Participants were recruited at the Gastroenterology Service of the Coimbra University Hospital between June and September 2019. Of the 355 patients screened, 61 participants were selected, randomly assigned to one of two conditions [experimental group (LIFEwithIBD + TAU) or control group (TAU)] and completed the baseline assessment. Outcome measurement took place at baseline, post-intervention, 3- and 12-month follow-ups.Discussion:Results from this RCT will support future studies testing the LIFEwithIBD intervention or other acceptance and/or compassion-based interventions for IBD.
The Comparison Between Different Hospital Market Definition Approaches: An Empirical Analysis of 11 Representative Diseases in Sichuan Province, China
Authors: Lu Liyong , Chen Ting , Lan Tianjao , Pan Jay 
Published: August 2021

Objective:This study aims to provide empirical evidence for the controversy about whether the inference is consistent if alternative hospital market definition methods are employed, and for which definition method is the best alternative to the predicted patient flow approach.Data sources:Collecting data from the discharge data of inpatients and hospital administrative data of Sichuan province in China in the fourth quarter of 2018.Study Design:We employed Herfindahl–Hirschman Index (HHI) as the proxy of market competition used as an example to measure the hospital market structure. Correlation coefficients of HHIs based on different definition methods were assessed. The corresponding coefficient of each HHI estimated in identical regression models was then compared. In addition, since the predicted patient flow method has been argued by the literature of its advantages compared with the previous approaches, we took the predicted patient flow as a reference to compare with the other approaches.Data Extraction Methods:We selected the common diseases with a significant burden, and 11 diseases were included (902,767 hospitalizations).Principal Findings:The correlation coefficients of HHIs based on different market definition methods are all significantly greater than 0, and the coefficients of HHIs are different in identical regression models. Taking the predicted patient flow approach as a reference, we found that the correlation coefficients between HHIs based on fixed radius and predicted patient flow approach is larger than others, and their parameter estimates are all consistent.Conclusion:Although the HHIs based on different definition methods are significantly and positively correlated, the inferences about the effectiveness of market structure would be inconsistent when alternative market definition methods are employed. The fixed radius would be the best alternative when researchers want to use the predicted patient flow method to define the hospital market but are hindered by the data limitations and computational complexity.
Tratamento com Dexametasona Reduz Atividade Exploratória de Ratos Wistar Jovens
Authors: Almeida Camila da Silva , Assis Ana Paula , Monteiro Marcella Oliveira , Chaves Valéria Ernestânia , De Castro Lima Maira 
Published: August 2021

Introdução. Dexametasona (DEX) é um glicocorticóide sintético com ação anti-inflamatória utilizado no tratamento de muitas doenças como artrite reumatoide, asma, alergias e doenças autoimunes. Estudos mostram que a DEX pode causar deficits cognitivos em animais, podendo estar relacionada com a redução na atividade exploratória, prejuízo na aprendizagem e memória espacial e aumento da ansiedade. Objetivo. O presente estudo investigou os efeitos da DEX sobre atividade exploratória, ansiedade e memória espacial em ratos jovens. Método. Ratos Wistar machos foram tratados com fosfato de dexametasona nas dosagens de 1 e 10 mg/Kg/dia durante 7 dias. No 5° dia de tratamento foi realizado o teste de campo aberto (CA) para avaliação da atividade exploratória; no 6° dia foi realizado o teste de labirinto em cruz elevado (LCE) para avaliação da ansiedade e no 7° dia foi realizado o teste de labirinto em T elevado (LTE) para avaliação da memória espacial. Resultados. No CA, houve redução de 48% no número total de quadrantes explorados no grupo DEX 10 mg/Kg, 46% e 56% de redução no número de quadrantes centrais explorados nos grupos DEX 1 e 10 mg/Kg, respectivamente, e 40% de redução no número de elevações no grupo DEX (10 mg/Kg), indicando que a DEX diminuiu a atividade exploratória dos animais tratados. Nos testes LCE e LTE não houve diferenças entre os grupos experimentais, indicando que a DEX não interferiu no comportamento de ansiedade e memória espacial. Conclusão. Nas condições experimentais deste estudo, a DEX diminuiu atividade exploratória mas não alterou ansiedade e memória espacial.
Optimasi Pembuatan Nanoselulosa dari Rumput Alang-Alang
Authors: Widiastuti Endang , Marlina Ari 
Published: August 2021

Pada era sekarang ini, pemanfaatan nanoselulosa sudah sangat luas pada berbagai bidang, seperti farmasi, kosmetik, elektronik, dirgantara, dsb. Proses pembuatan nanoselulosa dapat dilakukan dengan berbagai cara bergantung pada bahan baku selulosanya, tetapi secara umum meupakan kombinasi dari perlakuan kimia dan mekanik .Rumput alang-alang (Imperata Cylindrica) dapat dijadikan sebagai sumber selulosa dengan kandungan selulosanya berkisar 40%.
Ekstraksi selulosa dari rumput alang-alang diawali dengan proses delignifikasi dan dilanjutkan dengan proses bleaching menggunakan H2O2 dan NaOH. Serat selulosa diperoleh kemudian dihidrolisis dengan asam sulfat 64% pada suhu variasi 35 dan 45 ͦC, pengadukan divariasikan pada 250, 500 dan 750 rpm serta lamanya hidrolisis divariasikan 1, 2, dan 3 jam. Sebelum hasil hidrolisis dinetralkan terlebih dahulu disonifikasi dengan variasi waktu 20 dan 30 menit. Untuk pengujian hasilisolasi nano selulosa digunakan cara SEM (Scanning Electron Microscopes)
Dari penelitian ini, nano selulosa dari rumput alang-alang diperoleh melalui proses hidrolisis pada suhu 45 ℃, pengadukan 750 rpm, dan selama 3 jam, selanjutnya disonifikasi selama 30 menit. Kondisi ini digunakan untuk serat selulosa rumput alang-alang dalam keadaan kering.
El impacto de la pandemia en la educación media superior mexicana: un análisis desde lo pedagógico, psicológico y tecnológico
Authors: Medina-Gual Luis , Chao-Rebolledo Cimenna , Garduño-Teliz Elvia , Baptista-Lucio Pilar , González-Videgaray MariCarmen , Covarrubias-Santiago Carlos A. , Rivera-Navarro Miguel Ángel , Medina-Velázquez Luis , Montes-Pacheco Luz del Carmen , Sánchez-Rojas Leonardo Daniel , Ojeda-Núñez José Anibal 
Published: August 2021

Este artículo describe cómo las y los estudiantes y docentes mexicanos de Educación Media Superior (EMS) están adaptándose a la situación de emergencia sanitaria provocada por el COVID-19. Para ello se recolectaron datos en una muestra de n=11,850 docentes y n= 39,582 estudiantes que representan a diferentes estados, instituciones públicas y privadas ubicadas en contextos urbanos y rurales mexicanos. Un cuestionario en línea indagó tres dimensiones: la pedagógica, la psicológica y la tecnológica. Entre los principales hallazgos se encuentran los siguientes: pedagógicamente, docentes y estudiantes han sido flexibles, al adaptar métodos presenciales combinando recursos digitales y tradicionales. Tecnológicamente, solo la mitad de los docentes reportan una adecuada conectividad a Internet, lo que limita su uso de los recursos digitales. Psicológicamente, se identifica una prevalencia de estados emocionales aflictivos y de estrés, dando lugar a un estado de bienestar socioemocional general vulnerable. A través de análisis de árboles de regresión se revela la importancia de la evaluación del aprendizaje y el contacto con los estudiantes, tanto para el aprendizaje como para el bienestar socioemocional. La investigación es relevante porque permite ver fortalezas y áreas de oportunidad para el Sistema Educativo Mexicano (SEM).
Aula invertida en pandemia: Análisis de una experiencia disruptiva desde la mirada de los representantes
Authors: Sánchez-Santander Angélica María , Cárdenas-Cordero Nancy Marcela 
Published: August 2021

En la actualidad nos encontramos atravesando épocas de grandes cambios, tal es el caso del sector educativo que a raíz de la pandemia generada por la Covid-19 ha orillado a los docentes a utilizar recursos tecnológicos y metodologías activas en el afán de fortalecer el proceso de enseñanza aprendizaje. El objetivo de la presente investigación es Analizar cómo la aplicación del aula invertida puede aportar al aprendizaje de estudiantes desde la percepción de los representantes o padres de familia. De corte cuantitativo, descriptiva con diseño no experimental. El análisis del resultado evidencia que dicha metodología goza de gran popularidad tanto en estudiantes como en representantes ya que se ha comprobado que mejora el rendimiento académico frente a métodos tradicionales. Pero cabe señalar que por sí sola la aplicación del aula invertida no garantiza la mejora del desempeño académico puesto que son varios los factores que influyen en el proceso educativo.
naufragio poético
Authors: Castillo-García María Esther 
Published: August 2021

El escritor santafesino, Juan José Saer (1937-2005), nos propone en su novela El Entenado (2000) un viaje en busca de los orígenes a través de una exploración estilística en donde retoma ideas y abandona otras en una larga tradición literaria en donde reaparece la imagen del náufrago. Los términos y los objetivos de la fábula se circunscriben al origen de una aventura “real”, cuya materialidad es la palabra. En tanto gesto fundacional, esta ‘Poética de desplazamiento’ enuncia el trayecto de una travesía autorreflexiva, relativa a la causa, el efecto y la presencia de un hombre que describe e inventa la entelequia de su vida
Para fundamentar el qué de la urgencia de una errancia sobre el ser y el proceso escriturario consideramos referentes teóricos mínimos (Onfray, Ricoœur, Cabo, entre otros) que nos permitan incursionar en la novela de Saer como una de esas robinsonadas virtuales o encubiertas.
Scintillation characteristics of Nd3+-doped BaO–Al2O3–TeO2 glasses
Authors: Takaku Akito , Kawano Naoki , Kimura Hiromi , Nakauchi Daisuke , Akatsuka Masaki , Shinozaki Kenji , Yanagida Takayuki 
Published: August 2021

Abstract
Photoluminescence and scintillation characteristics of Nd3+-doped TeO2 glasses [(15–x)BaO–5Al2O3–80TeO2–xNd2O3 (x = 0.1–1.0)] were evaluated. The Nd3+-doped TeO2 glasses exhibited sharp emission peaks originating from the 4f–4f transition of Nd3+ in photoluminescence. The 0.1% Nd3+-doped TeO2 glass showed the highest quantum yield (about 33%). In addition, 0.1%–1.0% Nd3+-doped TeO2 glasses showed photoluminescence decay time constants in the time range of 128–194 μs originating from the 4F3/2 → 4I9/2 transition of Nd3+. In scintillation, the 0.1%–1.0% Nd3+-doped TeO2 glasses exhibited sharp scintillation peaks at around 905, 1060, and 1335 nm ascribed to the 4f–4f transitions of Nd3+. The 0.5% and 1.0% Nd3+-doped TeO2 glasses exhibited high intensities. The decay times of the Nd3+-doped TeO2 glasses under X-ray were in the time range of 123–174 μs. Moreover, the Nd3+-doped TeO2 glasses exhibited afterglow levels of about 618–829 ppm.
Систематический обзор и особенности его написания
Authors: Шленская Наталия Марковна , Хорохорина Галина Анатольевна 
Published: August 2021

Научные журналы публикуют оригинальные научные исследования авторов, результаты опытов и научных экспериментов, как первичную научную литературу, в то время как обзорные статьи также являются популярным и распространенным типом научных публикаций. Ежегодно во всем мире происходит рост числа научных публикаций в разных областях исследования, и обзорные статьи приобретают все большее значение, как публикации, помогающие оценить глубину проведенных исследований, провести их сопоставимость и выявить общие закономерности. Именно обзорные статьи позволяют определить направления дальнейших исследований и выявить факторы, которые можно устранить в исследованиях. Хотя само сопоставление первичных источников может быть проведено с использованием статистических методов, полное сравнение и анализ доступен только человеку. Статья рассматривает обзор, как перспективный тип научных публикаций. Приведена классификация обзоров и особенности написания систематического обзора. Проведено сравнение публикационной активности по типу статей «обзор» в базе Scopus в области пищевой и перерабатывающей промышленности.
Контроль активности воды в технологии лактулозосодержащей сыворотки
Authors: Пономарева Елена Ивановна , Титов Сергей Александрович , Жданов Всеволод Николаевич , Губарева Юлия Павловна , Терещенко Дарина Анатольевна 
Published: August 2021

Одним из основных способов обогащения молочной сыворотки пребиотическими веществами является модифицирование ее состава путем мембранной электрофлотации с последующей изомеризацией. В результате этих процессов происходит частичный переход содержащейся в сыворотке лактозы в лактулозу. В настоящей работе исследовали нанофильтрационное концентрирование лактулозосодержащей сыворотки, полученной мембранной электрофлотацией, с целью выяснения роли осмотических явлений в этом процессе. Зависимость скорости нанофильтрации сыворотки после электрофлотационной и термической обработки от концентрации сухих веществ имеет «плато», начинающееся при концентрации 8-10 %. Это связано с тем, что лактоза и минеральные соли в слоях сыворотки, прилегающих к мембране, связывают значительное количество воды в гидратных оболочках. Благодаря возникающему на мембране градиенту концентрации свободной воды происходит ее диффузия через мембрану. Измерения активности воды в лактулозосодержащей флотированной сыворотке в зависимости от концентрации сухих веществ подтверждают это предположение. На основании этих измерений сделана оценка увеличения концентрации сыворотки в пограничном слое по сравнению с объемом, оказавшегося равным 3. Влиянию гидратации сухих веществ сыворотки на скорость фильтрации можно дать теоретическое обоснование в рамках количественной физической модели, связывающей скорость фильтрации с активностью воды. Установлено, что использование лактулозосодержащей пищевой добавки на основе творожной сыворотки в производстве хлебобулочных изделий способствует получению готового продукта с пребиотическими свойствами. Кроме этого, применение модифицированной творожной сыворотки позволит обогатить полученное изделие минеральными веществами.