bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological and immunophenotypic features of early T cell precursor acute lymphoblastic leukaemia: A flow cytometry score for the initial diagnosis
Authors: Chandra Dinesh , Singh Manish K. , Gupta Ruchi , Rahman Khaliqur , Yadav Diksha Dev , Sarkar Manoj K. , Gupta Anshul , Yadav Sanjeev , Kashyap Rajesh , Nityanand Soniya 
Published: June 2021

AbstractObjectiveTo assess the prevalence of early T precursor‐acute lymphoblastic leukaemia (ETP‐ALL), study its clinicopathological features and devise a ‘flow score’ based on immunophenotypic profiles.Material MethodsThis was a retrospective study where clinical and laboratory data of all consecutive T‐ALL cases were analysed to identify features differentiating ETP from non‐ETP‐ALL. The utility of a flow score based on the five commonly used markers in leukaemia panels for T‐ALL (CD34, CD8, CD5, CD13 and CD33) was evaluated to differentiate ETP from non‐ETP‐ALL.ResultsEarly T precursor‐acute lymphoblastic leukaemia constituted 24.2% (n = 29) of all T‐ALL cases. It was significantly more common in adults (30.2%) as compared to paediatric (17.5%) patients (P = .046). The median age of presentation was significantly higher than the non‐ETP group. (24 vs 19 years; P = .01). Patients with ETP‐ALL usually presented with organomegaly, lymphadenopathy, lower levels of haemoglobin, total leucocyte count, peripheral blood blast proportion and LDH levels as compared to non‐ETP‐ALL. The majority of ETP‐ALL cases had L2 morphology with a moderate amount of cytoplasm showing frequent blebbing. A flow score cut‐off value of ≥3 on ROC curve analysis had a sensitivity and specificity of 100% and 94.6% respectively.ConclusionEarly T precursor‐acute lymphoblastic leukaemia had unique clinical and laboratory features. The prevalence of this entity is more common in the adult population. A flow score based on a minimum of five widely used markers can confidently identify ETP‐ALL and should be included in the primary panel of markers used for flow cytometric analysis.
Mapping the literature on financial well‐being: A systematic literature review and bibliometric analysis
Authors: Kaur Gagandeep , Singh Manjit , Singh Simarjeet 
Published: June 2021

AbstractThe field of personal finance has gained research momentum since the financial crisis of 2008, however, only few comprehensive reviews have been conducted to date. This study adopts a systematic review methodology to build a knowledge structure on financial well‐being. By combining bibliometric tools and content analysis, this study aims to capture insights not provided in earlier reviews, such as key authors, important journals, active countries and organisations, highly cited articles, and the prestige of reviewed papers. After reviewing 114 financial well‐being‐related papers, the study strives to highlight the factors associated with financial well‐being, as well as the relationships and critical theories underpinning research in this field. Based on the reviewed literature, research gaps are uncovered, and future research directions are provided to expand the knowledge in the area of financial well‐being.
The intergroup sensitivity effect in mergers and acquisitions: Testing the role of merger motives
Authors: Liang Shuang , Ullrich Johannes , van Dick Rolf , Lupina‐Wegener Anna 
Published: June 2021

AbstractResearch has shown that people are more defensive to criticism when it stems from an outgroup member, compared to an ingroup member (the intergroup sensitivity effect: ISE). We conducted two online vignette experiments to examine the ISE in the context of an organizational merger and the role of merger motives for the ISE. We predicted that the ISE would also emerge in mergers and acquisitions (M&As), but people would respond less negatively to criticism from the outgroup when the motive for the merger is described as achieving synergies rather than growth. In Experiment 1 (N = 452), which did not mention any motives behind the acquisition, a significant ISE emerged. Experiment 2 (N = 587) again showed an ISE regardless of the merger motive. In both experiments, the ISE was mediated by perceptions of the outgroup criticism as less legitimate and constructive. Overall, this research points to the intergroup sensitivity effect as a relevant phenomenon during post‐merger integration.
Victimization among children and adolescents accessing the Meyer pediatric hospital: A retrospective study
Authors: Nocentini Annalaura , Fiorentini Giada , Maffei Francesca , Martin Rosanna , Losi Stefania , Teodori Caterina , Pisano Tiziana , Gori Sara , De Luca Lisa , Menesini Ersilia 
Published: June 2021

AbstractProblemThe consistent prevalence and occasionally severe consequences of bullying and victimization suggest the need to include a more accurate assessment of these episodes within the Emergency Departments (ED). However, the literature on mental health related symptoms of bullying/victimization treated in the ED is still scarce. The aim of this study is to assess the prevalence of peer victimization amongst children and adolescents referred to an Italian Pediatric Emergency Department. Differences between Hospital Departments, type of victimization and ages are tested.MethodsA retrospective observational study was conducted with 705 subjects. The age range was from 6 to 18 years old (M = 13.09; SD = 3.048).Findings15.3% of the sample reported to be victimized (8.2% occasionally; 7.1% systematically). For the Child and Adolescent Psychiatry Unit, we found a significant association between peer victimization and being adolescent (Fisher's p = 0.003). In addition, a significant association was found between verbal victimization and Child and Adolescent Psychiatry Unit (Fisher's p = 0.02) and physical victimization and Child Abuse Department (Fisher's p < 0.001).ConclusionFindings suggest the importance of an accurate assessment of victimization experiences of children and adolescents with access to ED, to prevent future re‐victimization and crystallization of symptoms across time.
MACF1 alleviates aging‐related osteoporosis via HES1
Authors: Yin Chong , Tian Ye , Hu Lifang , Yu Yang , Wu Zixiang , Zhang Yan , Wang Xue , Miao Zhiping , Qian Airong 
Published: June 2021

AbstractAgeing‐related osteoporosis is becoming an emerging threat to human health along with the ageing of human population. The decreased rate of osteogenic differentiation and bone formation is the major cause of ageing‐related osteoporosis. Microtubule actin cross‐linking factor 1 (MACF1) is an important cytoskeletal factor that promotes osteogenic differentiation and bone formation. However, the relationship between MACF1 expression and ageing‐related osteoporosis remains unclear. This study has investigated the expression pattern of MACF1 in bone tissues of ageing‐related osteoporosis patients and ageing mice. The study has further elucidated the mechanism of MACF1 promoting bone formation by inhibiting HES1 expression and activity. Moreover, the therapeutic effect of MACF1 on ageing‐related osteoporosis and post‐menopausal osteoporosis was evaluated through in situ injection of the MACF1 overexpression plasmid. The study supplemented the molecular mechanisms between ageing and bone formation, and provided novel targets and potential therapeutic strategy for ageing‐related osteoporosis.
mTORC2 regulates hierarchical micro/nano topography‐induced osteogenic differentiation via promoting cell adhesion and cytoskeletal polymerization
Authors: Gao Qian , Hou Yuying , Li Zhe , Hu Jinyang , Huo Dawei , Zheng Huimin , Zhang Junjiang , Yao Xiaoyu , Gao Rui , Wu Xudong , Sui Lei 
Published: June 2021

AbstractSurface topography acts as an irreplaceable role in the long‐term success of intraosseous implants. In this study, we prepared the hierarchical micro/nano topography using selective laser melting combined with alkali heat treatment (SLM‐AHT) and explored the underlying mechanism of SLM‐AHT surface‐elicited osteogenesis. Our results show that cells cultured on SLM‐AHT surface possess the largest number of mature FAs and exhibit a cytoskeleton reorganization compared with control groups. SLM‐AHT surface could also significantly upregulate the expression of the cell adhesion‐related molecule p‐FAK, the osteogenic differentiation‐related molecules RUNX2 and OCN as well as the mTORC2 signalling pathway key molecule Rictor. Notably, after the knocked‐down of Rictor, there were no longer significant differences in the gene expression levels of the cell adhesion‐related molecules and osteogenic differentiation‐related molecules among the three titanium surfaces, and the cells on SLM‐AHT surface failed to trigger cytoskeleton reorganization. In conclusion, the results suggest that mTORC2 can regulate the hierarchical micro/nano topography‐mediated osteogenesis via cell adhesion and cytoskeletal reorganization.
Role of skeletal muscle lipids in the pathogenesis of insulin resistance of obesity and type 2 diabetes
Authors: Gilbert Marc 
Published: June 2021

ABSTRACTObesity predisposes individuals to the development of insulin resistance, which is a risk factor for type 2 diabetes, and muscle plays a central role in this phenomenon. Insulin resistance is associated with: (i) a metabolic inflexibility characterized by a reduced impaired switching from free fatty acid (FA) to carbohydrate substrates; and (ii) an ectopic accumulation of triglyceride in skeletal muscle, generating a cellular “lipotoxicity”, but triglyceride per se, does not contribute to insulin resistance (“athlete’s paradox”). A large body of evidence supports the idea that a decreased mitochondrial capacity to oxidize FA leads to an accretion of intracellular triglyceride and an accumulation of acyl‐CoAs, which are used to synthesize diacylglycerol and ceramide. These lipid derivatives activate serine kinases, leading to increase of insulin receptor substrate 1 serine phosphorylation, which impairs insulin signaling. A second model proposes that insulin resistance arises from an excessive mitochondrial FA oxidation. Studies have shown that the type of FA, unsaturated or saturated, is critical in the development of insulin resistance. It should be also stressed that FA oversupply activates inflammatory signals, induces endoplasmic reticulum stress, increases mitochondrial oxidative stress and influences the regulation of genes that contributes to impaired glucose metabolism. These cellular insults are thought to engage stress‐sensitive serine kinases disrupting insulin signaling. In conclusion, reduced dietary lipid intake in association with physical exercise could be a therapeutic option to improve insulin sensitivity.
Ozone nanobubble treatments improve survivability of Nile tilapia (Oreochromis niloticus) challenged with a pathogenic multi‐drug‐resistant Aeromonas hydrophila
Authors: Thanh Dien Le , Linh Nguyen Vu , Sangpo Pattiya , Senapin Saengchan , St‐Hilaire Sophie , Rodkhum Channarong , Dong Ha Thanh 
Published: June 2021

AbstractA rapid increase in multi‐drug‐resistant (MDR) bacteria in aquaculture highlights the risk of production losses due to diseases and potential public health concerns. Previously, we reported that ozone nanobubbles (NB‐O3) were effective at reducing concentrations of pathogenic bacteria in water and modulating fish immunity against pathogens; however, multiple treatments with direct NB‐O3 exposures caused alterations to the gills of exposed fish. Here, we set up a modified recirculation system (MRS) assembled with an NB‐O3 device (MRS‐NB‐O3) to investigate whether MRS‐NB‐O3 (a) were safe for tilapia (Oreochromis niloticus), (b) were effective at reducing bacterial load in rearing water and (c) improved survivability of Nile tilapia following an immersion challenge with a lethal dose of MDR Aeromonas hydrophila. The results showed no behavioural abnormalities or mortality of Nile tilapia during the 14‐day study using the MRS‐NB‐O3 system. In the immersion challenge, although high bacterial concentration (~2 × 107 CFU/ml) was used, multiple NB‐O3 treatments in the first two days reduced the bacteria between 15.9% and 35.6% of bacterial load in water, while bacterial concentration increased from 13.1% to 27.9% in the untreated control. There was slight up‐regulation of non‐specific immune‐related genes in the gills of the fish receiving NB‐O3 treatments. Most importantly, this treatment significantly improved survivability of Nile tilapia with relative percentage survival (RPS) of 64.7% – 66.7% in treated fish and surviving fish developed specific antibody against MDR A. hydrophila. In summary, the result suggests that NB‐O3 is a promising non‐antibiotic approach to control bacterial diseases, including MDR bacteria, and has high potential for application in recirculation aquaculture system (RAS).
Exploring nonlinear linkage between profitability and leverage: US multinational versus domestic corporations
Authors: Alnori Faisal 
Published: June 2021

AbstractThis study examines the impact of profitability on the capital structure decision of US multinational and domestic corporations. The findings reveal that the relationship between multinational corporations’ (MNCs') profitability and their leverage ratios is U‐shaped and nonlinear, while this nonlinear relation does not exist for domestic firms (DCs). This nonlinear relationship indicates that the effect of profitability on multinational corporations' leverage depends on the levels of their profitability. Consistent with the dominance of the pecking order theory, lower‐profitability MNCs have a tax shield advantage that does not outweigh the information asymmetry costs of debt financing. Conversely, higher‐profitability MNCs have a tax shield advantage that outweighs the information asymmetry costs of debt financing. The findings are robust after using two different classifications for multinational firms, including foreign tax and foreign sales; after applying an alternative methodology and during different time horizons.
Possible clinical efficacy and tolerability of platelet‐rich plasma with atopic dermatitis
Authors: Yosef Ayman , Elkady Nada , Khattab Fathia 
Published: June 2021

AbstractBackgroundNarrowband‐ultraviolet B (NB‐UVB) is a promising, effective, and safe therapeutic option for atopic dermatitis (AD), but the treating courses frequently need an extended period since they might have a possible hazard for several side effects and cases of non‐compliance.ObjectiveTo discover the influence of platelet‐rich plasma (PRP) injecting on the outcomes of short‐term NB‐UVB treatment for AD cases.Patients and methodsThe present study includes 44 atopic dermatitis cases with general symmetric lesions. For every case, the left side of the body was treated with NB‐UVB (control side) whereas the right side was treated with NB‐UVB plus PRP intradermal injection, at 3–week interval for 3–months.ResultsA statistically high significant reduction was found in the EASI score, IGA score in the combined side (PRP plus NB‐UVB) in comparison with NB‐UVB side.ConclusionIntradermal PRP injecting in addition to NB‐UVB can be considered as a simple, acceptable, and economical method for treating atopic dermatitis. It decreases the NB‐UVB therapeutic period and is predictable to raise case compliance. Assessments through follow‐up were proposed and undertaken to rate the efficacy of treatment.
The effect of salutogenesis‐based care on the sense of coherence in peritoneal dialysis patients
Authors: Uzdil Nurcan , Ceyhan Özlem , Şimşek Nuray 
Published: June 2021

AbstractAimsThis research is conducted to determine the effect of salutogenesis‐based home care on the sense of coherence in patients with peritoneal dialysis.BackgroundRecent studies on the salutogenesis model have shown that the model is effective in promoting and improving health. It was observed that studies based on the salutogenesis model were carried out in the form of a training programme, and there was no study that shows its effectiveness on patient care by integrating it into the nursing process.DesignThe research is conducted as a pre‐test–post‐test control group experimental study.MethodsThe study included 73 patients, including 36 in the intervention group and 37 in the control group. The research data are collected using the Patient Identifier Information Form, Dialysis Symptom Index (DSI), General Self‐Efficacy Scale (GSES) and the Sense of Coherence Scale (SIS). The intervention group is provided care based on the salutogenesis model by making home visits 1 time per week for 8 weeks. In this study, the TREND checklist was followed for non‐randomised controlled trials.ResultsIn the study, the pre‐test DSI, GSES and SIS (meaningfulness, comprehensibility, manageability sub‐dimension) mean scores of the individuals in the intervention and control groups are similar. The third‐month and sixth‐month intervention group SIS total and sub‐dimension scores and GSES scores are found to be statistically significantly higher than the scores of the control group.ConclusionsAs a result of the study, it is determined that the care based on the salutogenesis model provided to peritoneal dialysis patients increases the sense of coherence and self‐efficacy and provides symptom control and decreases the dialysis symptoms.Relevance to clinical practiceIt has been observed that the salutogenesis model can be used as a step of nursing care in providing symptom control by strengthening the self‐efficacy of patients in clinical and home care.
Building capacity in times of crisis: Increasing cultural competence of healthcare professionals in the context of the COVID‐19
Authors: Slobodin Ortal , Kula Yosef , Clempert Neta , Cohen Odeya 
Published: June 2021

BackgroundNurses are the frontline healthcare professionals fighting the medical and social effects of the current COVID‐19 pandemic. Although they work with diverse populations, there is a lack of literature on culturally competent education during an emergency such as a pandemic.Aims and objectivesTo examine the effectiveness of an online education programme aimed at increasing cultural competence among rescue teams and healthcare professionals facing the challenges of the COVID‐19 pandemic.DesignPre–post‐web‐based intervention study.MethodsPre–post‐intervention surveys were administered to a matched sample of Israeli healthcare and rescue organisation professionals. The initial sample included 303 participants (52% women) who completed the pre‐intervention survey. More than half of the sample (56%, n = 170) were paid workers or volunteers in health organisations. Of the initial sample, 154 participants completed the post‐intervention survey following the online cultural competence education programme. Descriptive statistics and multivariate analysis were used to evaluate participants’ gains in culturally competent attitudes, knowledge, skills and encounters. This study followed the STROBE guidelines.ResultsParticipants found the online programme useful in improving their cultural competence during the COVID‐19 pandemic. The highest gains were found in the attitudes domains, whereas the lowest in the knowledge domain. Pre‐intervention cultural competence scores and incorporating the programme in the educational curricula predicted increased gains in cultural competence.ConclusionsOnline educational interventions showed potential for increasing professionals’ awareness of cultural biases, differences and attitudes, leading to more open and accepting attitudes towards patients of different backgrounds.Relevance to clinical practiceRecognising the need for real‐time, low‐cost and available training, the World Health Organization recommended using online courses for healthcare professionals struggling in the pandemic frontline. Online education programmes provide a useful platform for training health professionals in times of emergency.
Macrosomia and large for gestational age in Asia: One size does not fit all
Authors: Harvey Louise , van Elburg Ruurd , van der Beek Eline M. 
Published: June 2021

AbstractMacrosomia, usually defined as infant birth weight of ≥4000 g, does not consider gestational age, sex, or country/region‐specific differences in mean birth weight and maternal body weight. This issue is particularly relevant for Asia, where 60% of the world's population lives, due to variations in maternal size and birth weights across populations. Large for gestational age (LGA), defined as birth weight > 90th centile, is a more sensitive measure as it considers gestational age and sex, though it is dependent on the choice of growth charts. We aimed to review reporting of macrosomia and LGA in Asia. We reviewed the literature on prevalence and risk of macrosomia and LGA in Asia over the last 29 years. Prevalence of macrosomia ranged from 0.5% (India) to 13.9% (China) while prevalence of LGA ranged from 4.3% (Korea) to 22.1% (China), indicating substantial variation in prevalence within and between Asian countries. High pre‐pregnancy body mass index, excessive gestational weight gain, and impaired glucose tolerance conferred risk of macrosomia/LGA. Incidence of macrosomia and LGA varies substantially within and between Asian countries, as do the growth charts and definitions. The latter makes it impossible to make comparisons but suggests differences in intrauterine growth between populations. Reporting LGA, using standardized country/regional growth charts, would better capture the incidence of high birth weight and allow for comparison and identification of contributing factors. Better understanding of local drivers of excessive intrauterine growth could enable development of improved strategies for prevention and management of LGA.
Transcranial Doppler to evaluate postreperfusion therapy following acute ischemic stroke: A literature review
Authors: Shahripour Reza Bavarsad , Azarpazhooh M. Reza , Akhuanzada Humayon , Labin Edward , Borhani‐Haghighi Afshin , Agrawal Kunal , Meyer Dawn , Meyer Brett , Hemmen Thomas 
Published: June 2021

AbstractCerebral vessel recanalization therapy, either intravenous thrombolysis or mechanical thrombectomy, is the main treatment that can significantly improve clinical outcomes after acute ischemic stroke. The degree of recanalization and cerebral reperfusion of the ischemic penumbra are dependent on cerebral hemodynamics. Currently, the main imaging modalities to assess reperfusion are MRI and CT perfusion. However, these imaging techniques cannot predict reperfusion‐associated complications and are not readily available in many centers. It is also not feasible to repeat them frequently for sequential assessments, which is important because of the changing nature of cerebral hemodynamics following stroke. Transcranial Doppler sonography (TCD) is a valid, safe, and inexpensive technique that can assess recanalized vessels and reperfused tissue in real‐time at the bedside. Post thrombectomy reocclusion, hyperperfusion syndrome, distal embolization, and remote infarction result in poor outcomes after mechanical or intravenous reperfusion therapy. Managing blood pressure following these endovascular treatments can also be a dilemma. TCD has an important role, with major clinical implications, in evaluating cerebral hemodynamics and collateral vessel status, guiding clinicians in making individualized decisions based on cerebral blood flow during acute stroke care. This review summarizes the most relevant literature on the role of TCD in evaluating patients after reperfusion therapy. We also discuss the importance of performing TCD in the first few hours following thrombolytic therapy in identifying hyperperfusion syndrome and embolic signals, predicting recurrent stroke, and detecting reocclusions, all of which may help improve patient prognosis. We recommend TCD during the hyperacute phase of stroke in comprehensive stroke centers.