bluuebunny/crossref_metadata_2025_split huggingface dataset:
A fast and high‐sensitivity liquid chromatography–tandem mass spectrometry method combined with in vivo microdialysis for quantification of meropenem in rabbits with sepsis under the simultaneous infusion of total parenteral nutrition: Application to a pharmacokinetic study
Authors: Fei Yibo , Wu Shengyuan , Wang Yuanyuan , Shen Fuming , Fan Guorong 
Published: February 2021

AbstractA fast and high‐sensitivity liquid chromatography–tandem mass spectrometry (LC–MS/MS) method assisted by microdialysis was established for the determination of meropenem in total parenteral nutrition (TPN) infused plasma. A 10‐times dilution was arranged for sample preparation to overcome the severe matrix effect caused by the high salt content in dialysate and complex composition of TPN. This quantification method was proved to be satisfied in selectivity, accuracy, precision, linearity (R2 > 0.998), recovery, matrix effect and stability. In the optimized conditions, the calibration curve range was set from 2 to 2000 ng/ml. This validated method was applied to pharmacokinetics study of meropenem in rabbits with sepsis (induced by cecal ligation and punctures) under simultaneous infusion of TPN to simulate the clinical practice. The results demonstrated that the LC–MS/MS method assisted by microdialysis can be used successfully for the determination of meropenem in TPN‐infused plasma. Moreover, the area under the curve and the maximum concentrations in the plasma of meropenem in control rabbits were significantly smaller (P < 0.05), while clearance and distribution volumes were significantly greater (P < 0.05) than in those with sepsis. It could be speculated that drug monitoring in patients with sepsis may be necessary.
Body composition and risk of gastric cancer: A population‐based prospective cohort study
Authors: Liu An‐Ran , He Qiang‐Sheng , Wu Wen‐Hui , Du Jian‐Liang , Kuo Zi‐Chong , Xia Bin , Tang Yan , Yun Peng , Cheung Eddie C. , Tang You‐Zhen , He Yu‐Long , Zhang Chang‐Hua , Yuan Jin‐Qiu , Sun Gang 
Published: February 2021

ABSTRACTThe recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer.
Milling method affects the physical properties of black bean flour
Authors: Fernando Supun , Manthey Frank A. 
Published: February 2021

AbstractBackground and objectivesDry bean milling has attracted interest due to the increased need for nonwheat ingredients available for food applications. The objective of this study was to examine the physical and flow properties of black bean flour produced using a variety of laboratory mills and mill settings.FindingsFlour from mills which utilized screens (cyclone mill, centrifugal mill, and hammer mill) showed significantly different characteristics than flour from mills without a screen (disk mill and stone mill). Geometric mean size of flour particles was negatively correlated with starch damage (r = −.92), L* (r = −.94), angle of repose (r = −.94), and angle of slide (r = −.80 to −.90, depending on surface material) and positively correlated with moisture content (r = .72) and loose bulk density (r = .72). Finely ground flour resulted in particles that tended to be less circular and more elongated and had high angles of repose and slide.ConclusionsMilling method significantly affected (p < .05) physical and flow properties of black bean flour.Significance and noveltyThese findings can be used by food processors in selecting a milling method that favors the production of black bean flour with the desired physical properties.
Charge Transfer Kinetics at Ag(111) Single Crystal Electrode/Ionic Liquid Interfaces: Dependence on the Cation Alkyl Side Chain Length
Authors: Li Miangang , Liu Shuai , Xie Liqiang , Yan Jiawei , Lagrost Corinne , Wang Shuai , Feng Guang , Hapiot Philippe , Mao Bingwei 
Published: February 2021

AbstractThe influences of the electrode/ionic liquids interfaces on the charge transfer kinetics are addressed with the example of the oxidation of chromocene at a single crystal Ag(111) electrode. We considered three different imidazolium‐based room temperature ionic liquids (RTILs) with alkyl chains of different lengths but with a common anion. The standard charge transfer rate constants k° are extracted from cyclic voltammograms (CVs) by analyzing the peak potential variations with the scan rate and/or performing semi‐integral electroanalysis with a careful treatment of the ohmic drop. Linear variations between the logarithms of k° and the longitudinal relaxation times τL or the dynamic viscosity η of the ionic liquids are obtained. However, the amplitude of the decrease is much larger than it could be expected from the sole bulk properties of the ionic liquid indicating a strong effect of the interface on the kinetics. These observations agree with a well‐organized electrode/RTIL interface that behaves as a sort of self‐assembled monolayer that controls the charge transfer kinetics with an exponential tunneling coefficient β of 5.51 nm−1.
Architecture engineering of carbonaceous anodes for high‐rate potassium‐ion batteries
Authors: Wu Tianlai , Zhang Weicai , Yang Jiaying , Lu Qiongqiong , Peng Jing , Zheng Mingtao , Xu Fei , Liu Yingliang , Liang Yeru 
Published: February 2021

AbstractThe limited lithium resource in earth's crust has stimulated the pursuit of alternative energy storage technologies to lithium‐ion battery. Potassium‐ion batteries (KIBs) are regarded as a kind of promising candidate for large‐scale energy storage owing to the high abundance and low cost of potassium resources. Nevertheless, further development and wide application of KIBs are still challenged by several obstacles, one of which is their fast capacity deterioration at high rates. A considerable amount of effort has recently been devoted to address this problem by developing advanced carbonaceous anode materials with diverse structures and morphologies. This review presents and highlights how the architecture engineering of carbonaceous anode materials gives rise to high‐rate performances for KIBs, and also the beneficial conceptions are consciously extracted from the recent progress. Particularly, basic insights into the recent engineering strategies, structural innovation, and the related advances of carbonaceous anodes for high‐rate KIBs are under specific concerns. Based on the achievements attained so far, a perspective on the foregoing, and proposed possible directions, and avenues for designing high‐rate anodes, are presented finally.
Mycophenolic Acid Exposure Prediction Using Machine Learning
Authors: Woillard Jean‐Baptiste , Labriffe Marc , Debord Jean , Marquet Pierre 
Published: February 2021

Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well‐established and machine learning (ML) approaches could help to estimate AUC. The aim of this work is to estimate the AUC of MPA in organ transplant patients using extreme gradient boosting (Xgboost R package) ML models. A total of 12,877 MPA AUC from 0 to 12 hours (AUC0–12 h) requests from 6,884 patients sent to our Immunosuppressant Bayesian Dose Adjustment expert system (https://abis.chu‐limoges.fr) for AUC estimation and dose recommendation based on MPA concentrations measured at least at three sampling times (~ 20 minutes, 1 and 3 hours after dosing) were used to develop two ML models based on two or three concentrations. Data were split into a training set (75%) and a test set (25%) and the Xgboost models in the training set with the lowest root mean squared error (RMSE) in a 10‐fold cross‐validation experiment were evaluated in the test set and in 4 independent full‐pharmacokinetic (PK) datasets from renal or heart transplant recipients. ML models based on two or three concentrations, differences between these concentrations, relative deviations from theoretical times of sampling, presence of a delayed absorption peak, and five covariates (dose, type of transplantation, associated immunosuppressant, age, and time between transplantation and sampling) yielded accurate AUC estimation performances in the test datasets (relative bias < 5% and relative RMSE < 20%) and better performance than MAP Bayesian estimation in the four independent full‐PK datasets. The Xgboost ML models described allow accurate estimation of MPA AUC0–12 h and can be used for routine exposure estimation and dose adjustment and will soon be implemented in a dedicated web interface.
Metasequoia‐like Nanocrystal of Iron‐Doped Copper for Efficient Electrocatalytic Nitrate Reduction into Ammonia in Neutral Media
Authors: Wang Changhong , Liu Zhengyang , Hu Tao , Li Jingsha , Dong Liuqi , Du Feng , Li Changming , Guo Chunxian 
Published: February 2021

AbstractIt is of significance to design catalysts for achieving high‐performance electrochemical nitrate reduction to ammonia (NRA) in mild neutral media. However, the faradaic efficiency and selectivity are still far from satisfactory. Here, the fabrication of an efficient catalyst was achieved by rationally doping Fe to Cu into a metasequoia‐like nanocrystal of CuFe for NRA in neutral media. Fe doping was found to deepen energy level of the Cu 3d band, favorably tuning adsorption energies of reaction intermediates to promote the NRA. At an applied potential of −0.7 V vs. the reversible hydrogen electrode, the CuFe with approximately 2 % Fe doping content delivered a catalytic current density of 55.6 mA cm−2, which was 2.1 times that of the Cu material. The CuFe also exhibited a faradaic efficiency up to 94.5 %, and a good selectivity of 86.8 %.
Parental feeding practices and children's disordered eating among single parents and co‐parents
Authors: Kamody Rebecca C. , Lydecker Janet A. 
Published: February 2021

AbstractObjectiveSome parental feeding practices are associated with pediatric disordered eating and weight status. Existing research, however, has focused on maternal feeding practices in co‐parent households. Single parents and fathers are notably understudied in this area. The current study examined associations of parental feeding practices with child disordered eating behaviors and weight, and compared associations between single mothers and fathers with a matched sample of co‐parenting mothers and fathers.MethodParents (N = 524) of youth between 5 and 16 years completed an online survey that included measures of parental feeding practices and unhealthy eating/weight‐related parenting practices. Co‐parents were matched to each single parent based on gender, race, ethnicity, education level, age, and BMI.ResultsSingle parents reported significantly greater concern about their child's weight, eating and shape, and reported engaging in more restraint and restriction of their child's eating, as well as having more perceived responsibility of their child's eating than caregivers in co‐parent households. Children of single parents were significantly more likely to engage in secretive eating.DiscussionAssociations between single parents' feeding practices and child weight and disordered eating parallel the broader literature. There were differences between single mothers and fathers and co‐parenting mothers and fathers, particularly in their report of their unhealthy eating/weight‐related parenting practices. Such differences may influence children's longer‐term eating behaviors and weight status. Further research on single‐parent households is needed, including longitudinal and epidemiological studies.
Can you find the right support for children, adolescents and young adults with anorexia nervosa: Access to age‐appropriate care systems in various healthcare systems
Authors: Herpertz‐Dahlmann Beate , Bonin Eva , Dahmen Brigitte 
Published: February 2021

AbstractObjectiveAnorexia nervosa (AN) often has its onset in childhood or adolescence. However, there is insufficient knowledge regarding access to and utilisation of age‐specific clinical diagnostics and treatment.MethodsA literature review covering the last 10 years was conducted to provide a narrative review of the current state of research on the detection and treatment of young patients with AN in primary and secondary care.ResultsMost articles were of Western European or US origin. Timely diagnosis of the eating disorder (ED) and treatment options more often depend on the structure and quality of the national health care system than on scientific evidence. Regular paediatric health check‐ups and age‐appropriate eating disorder services appear to facilitate early diagnosis. Age‐specific treatment that also involves the carers is often associated with a higher continuity of care and a better outcome. Although many adolescents require an extension of treatment into young adulthood, individual and health care system‐related obstacles in many countries prevent a smooth transition.ConclusionTo improve outcomes in childhood and adolescent AN, age‐specific and timely diagnostic and therapeutic procedures are urgently needed.
Amphioxus neuroglia: Molecular characterization and evidence for early compartmentalization of the developing nerve cord
Authors: Bozzo Matteo , Lacalli Thurston C. , Obino Valentina , Caicci Federico , Marcenaro Emanuela , Bachetti Tiziana , Manni Lucia , Pestarino Mario , Schubert Michael , Candiani Simona 
Published: February 2021

AbstractGlial cells play important roles in the development and homeostasis of metazoan nervous systems. However, while their involvement in the development and function in the central nervous system (CNS) of vertebrates is increasingly well understood, much less is known about invertebrate glia and the evolutionary history of glial cells more generally. An investigation into amphioxus glia is therefore timely, as this organism is the best living proxy for the last common ancestor of all chordates, and hence provides a window into the role of glial cell development and function at the transition of invertebrates and vertebrates. We report here our findings on amphioxus glia as characterized by molecular probes correlated with anatomical data at the transmission electron microscopy (TEM) level. The results show that amphioxus glial lineages express genes typical of vertebrate astroglia and radial glia, and that they segregate early in development, forming what appears to be a spatially separate cell proliferation zone positioned laterally, between the dorsal and ventral zones of neural cell proliferation. Our study provides strong evidence for the presence of vertebrate‐type glial cells in amphioxus, while highlighting the role played by segregated progenitor cell pools in CNS development. There are implications also for our understanding of glial cells in a broader evolutionary context, and insights into patterns of precursor cell deployment in the chordate nerve cord.
Classification of multiple sclerosis based on patterns ofCNSregional atrophy covariance
Authors: Tsagkas Charidimos , Parmar Katrin , Pezold Simon , Barro Christian , Chakravarty Mallar M. , Gaetano Laura , Naegelin Yvonne , Amann Michael , Papadopoulou Athina , Wuerfel Jens , Kappos Ludwig , Kuhle Jens , Sprenger Till , Granziera Cristina , Magon Stefano 
Published: February 2021

AbstractThere is evidence that multiple sclerosis (MS) pathology leads to distinct patterns of volume loss over time (VLOT) in different central nervous system (CNS) structures. We aimed to use such patterns to identify patient subgroups. MS patients of all classical disease phenotypes underwent annual clinical, blood, and MRI examinations over 6 years. Spinal, striatal, pallidal, thalamic, cortical, white matter, and T2‐weighted lesion volumes as well as serum neurofilament light chain (sNfL) were quantified. CNS VLOT patterns were identified using principal component analysis and patients were classified using hierarchical cluster analysis. 225 MS patients were classified into four distinct Groups A, B, C, and D including 14, 59, 141, and 11 patients, respectively). These groups did not differ in baseline demographics, disease duration, disease phenotype distribution, and lesion‐load expansion. Interestingly, Group A showed pronounced spinothalamic VLOT, Group B marked pallidal VLOT, Group C small between‐structure VLOT differences, and Group D myelocortical volume increase and pronounced white matter VLOT. Neurologic deficits were more severe and progressed faster in Group A that also had higher mean sNfL levels than all other groups. Group B experienced more frequent relapses than Group C. In conclusion, there are distinct patterns of VLOT across the CNS in MS patients, which do not overlap with clinical MS subtypes and are independent of disease duration and lesion‐load but are partially associated to sNfL levels, relapse rates, and clinical worsening. Our findings support the need for a more biologic classification of MS subtypes including volumetric and body‐fluid markers.
Aiding decision makers to reopening of places of worship
Authors: Rothrock Ling , Abraham Aaron , Graf Allison , Rodopman Mina , Nold Dan 
Published: February 2021

AbstractObjectiveOur research objective is to work with leaders of houses of worship in the local community to assess options for the physically reopening of places of worship.MethodThis study consists of two parts. The first part consists of working with a leader of a house of worship to formulate a decision process based on the priorities of the organization and its physical size and population. The second part involves the modeling of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus spread within a physical space to provide the leadership of the house of worship an estimate of the outcomes of deciding on various courses of action. The model is a modification of a standard virus model developed for the NetLogo programming environment.ResultsThe team worked with a large local church in Pennsylvania to physically reopen a worship service. Based on the questionnaire data, the congregation did not prefer the strongest form of the SARS‐CoV‐2 virus mitigation (mask wearing and social distancing) but favored either mask required and no social distancing or masks optional and social distancing. The team simulated conditions representative of the church and found that social distancing is the key factor to mitigate spread.ConclusionGiven the preferences of the congregation, our simulation results suggested that one of the favored options would likely yield a large number of infections (>10% in a scenario with an asymptomatic carrier). This information was provided to the leadership to guide their decision‐making for the coming months as poor weather will rule out outdoor worship as a viable option.
Investigating employee and organizational performance in across‐borderacquisition—A case of withdrawal behavior
Authors: Tian Anna Yumiao , Ahammad Mohammad Faisal , Tarba Shlomo Yedidia , Pereira Vijay , Arslan Ahmad , Khan Zaheer 
Published: February 2021

AbstractOver the last two decades, performance management systems (PMSs) have been the focus of increasing attention. However, scant research has examined the link between individual‐ and organizational‐level performance in the context of cross‐border mergers and acquisitions. Employee withdrawal adversely affects organizations, and has thus been associated with negative consequences for organizations and regarded as a counterproductive work behavior. Our article presents an empirical investigation of determinants and consequences of employee withdrawal, and its impact on willingness to share tacit knowledge, knowledge transfer, and cross‐border acquisition performance in the context of Chinese acquisitions in the UK. Based on a cross‐sectional survey of 103 employees of an UK subsidiary and Chinese acquiring firm, we found that trust in the acquiring firm significantly reduces acquired firm employee withdrawal behaviors. Moreover, our findings indicate that employee withdrawal behaviors negatively impact employee willingness to share tacit knowledge. The findings further confirm that such willingness positively influences knowledge transfer, which, in turn, has a positive effect on cross border acquisition performance. Our article contributes to the PMS literature by enhancing the understanding of the process through which human resource management systems affect outcomes at different levels of analysis in the context of the cross‐border acquisitions.
Parent personality and children's inattention/hyperactivity problems are related via early caregiving
Authors: Mohamed Ali Ola , Kotelnikova Yuliya , Kryski Katie R. , Durbin C. Emily , Hayden Elizabeth P. 
Published: February 2021

AbstractDiverse mechanisms account for the familial aggregation of certain personality traits and externalizing psychopathology. We explored the roles of positive and negative parenting as mediators of longitudinal associations between parents' maladaptive personality traits and their children's inattention/hyperactivity problems. We collected self, informant and observational measures of parent personality, parenting and child symptoms from a community sample of 409 children (208 girls) and their primary caregiver across three waves of data collection at child ages 3, 5 and 8 years. Primary caregiver's negative temperament, mistrust and aggression were positively associated with children's symptoms of hyperactivity/inattention. While parenting was unrelated to self‐reported traits, responsive parenting mediated negative associations between informant‐reported maladaptive parent traits and children's hyperactivity/inattention. In addition, informant‐reported trait aggression predicted boys' ADHD symptoms via hostile parenting. Findings implicate mechanisms that may underlie intergenerational transmission and continuity of inattention/hyperactivity and highlight the importance of multi‐informant, multi‐method approaches when studying relationships between parent traits and child outcomes.Highlights
Parents' trait aggression predicts boys' ADHD symptoms, partially via caregiving.
Mechanisms that link parents' traits to child ADHD symptoms are trait‐specific.
Informant‐, but not self‐, reported parent personality was related to parenting.