bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of cone-beam computed tomography for scaphoid fractures: a systematic review and diagnostic meta-analysis
Authors: Yang Ta-Wei , Lin Yen-Yue , Hsu Shih-Chang , Chu Karen Chia-Wen , Hsiao Chih-Wei , Hsu Chin-Wang , Bai Chyi-Huey , Chang Cheng-Kuang , Hsu Yuan-Pin 
Published: January 2021

AbstractScaphoid fractures are the most common carpal fractures. Diagnosing scaphoid fractures is challenging. Recently, cone-beam computed tomography (CBCT) has been shown to be a promising strategy for diagnosing scaphoid fractures. The diagnostic performance of CBCT remains inconclusive in the literature. Through a systematic review and meta-analysis, our study aims to determine the diagnostic performance of CBCT for diagnosing scaphoid fractures. Five databases were searched up to March 25, 2020. We included prospective and retrospective studies describing the diagnostic accuracy of CBCT for scaphoid fractures in adult patients. QUADAS-2 tool was used to assess the quality of the included studies. Four studies (n = 350) were included in the meta-analysis. Three of the four studies had high bias risk. The result showed that CBCT had a pooled sensitivity of 0.88 and a pooled specificity of 0.99 for scaphoid fracture diagnosis. The heterogeneities of sensitivity and specificity were substantial. The area under the summary receiver operating characteristic curve was 0.98. No significant publication bias was observed. The result suggested that the diagnostic performance of CBCT for scaphoid fracture was excellent. The certainty of current evidence is low. Further well-designed studies with large sample sizes are warranted to confirm this finding.
First-principles calculation of 11B solid-state NMR parameters of boron-rich compounds II: the orthorhombic phases MgB7 and MgB12C2 and the boron modification γ-B28
Authors: Ludwig Martin , Hillebrecht Harald 
Published: January 2021

After referencing 11B NMR spectra for molecular icosahedral boranes and the subsequent transfer to boron-rich borides of the α-rB12 type, we show that NMR spectra of borides with four or five symmetry-independent boron atoms can also be calculated.
Auditory brainstem responses in aging dark agouti rats
Authors: Beltrame Angela K. , Dahms Nancy M. , Runge Christina L. 
Published: January 2021

AbstractThe present study examined auditory function across age in the dark agouti (DA) rat strain. Auditory brainstem responses (ABRs) were measured for frequencies 8, 16, and 32 kHz in male and female DA rats from 3 to 18 months of age. Hearing thresholds and absolute and interpeak latencies (IPLs) were analyzed. Male hearing thresholds remained stable for the first year of life and then significantly increased at 18 months across all frequencies; female hearing remained stable at all tested ages out to 18 months. At 12 months, male DA rats showed significantly longer absolute latencies by age (i.e., compared with 3-month-old males) and sex (compared with 12-month-old females), with no differences in IPLs. At 18 months, female DA rats showed significantly longer absolute latencies with age (compared with 3-month-old females) and sex (compared with 18-month-old males), particularly for the later waves. Female IPLs were also significantly longer with age and by sex for the later waves. This report supports the feasibility of using male DA rats in studies to investigate age-related hearing loss (ARHL; presbycusis).
SNHG15 knockdown inhibits diabetic nephropathy progression in pediatric patients by regulating the miR-141/ICAM-1 axisin vitro
Authors: Liu Jiewei , Cai Dongliang , Wang Ying , Zou Yanhong , Zhao Tana 
Published: January 2021

AbstractLong non-coding RNAs (lncRNAs) are confirmed to be involved in modulating diabetic nephropathy (DN). The present study is aimed to explore the regulatory mechanism of lncRNA small nucleolar RNA host gene 15 (SNHG15) on pediatric DN. Human glomerular mesangial cells (HGMCs) were exposed to high glucose (HG) to produce an in vitro model. The results showed that SNHG15 was remarkably up-regulated in pediatric DN tissues and HG-induced HGMCs. Functional experiments indicated that both silencing of SNHG15 and overexpression of miR-141 elevated the cell viability, and suppressed the inflammation in HG-induced HGMCs. SNHG15 was identified to be a lncRNA that could bind to miR-141, and ICAM-1 was a downstream target gene of miR-141. Both the low expression of miR-141 and high expression of ICAM-1 reversed the inhibiting effect of SNHG15 knockdown on inflammatory response, and the promoting effect on cell viability. To conclude, our study revealed that silencing of SNHG15 ameliorated the malignant behaviors of pediatric DN via modulating the miR-141/ICAM-1 axis in vitro.
Gravesʼ Orbitopathy: Current Concepts for Medical Treatment
Authors: Oeverhaus Michael , Stöhr Mareile , Möller Lars , Führer Dagmar , Eckstein Anja 
Published: January 2021

Abstract
Background The therapy of severe manifestations of Gravesʼ orbitopathy (GO) is still a challenge and requires good interdisciplinary cooperation. It is especially important to use stage-adapted anti-inflammatory therapy to avoid irreversible damage.
Material and Methods Discussion of the latest results of multicentre randomised therapy studies on anti-inflammatory treatments for Gravesʼ orbitopathy, as well as new therapeutic concepts.
Results Mild cases of GO can be treated with only selenium supplementation and a watchful waiting strategy. In the moderate-to-severe active form of GO, primary therapy consists of i. v. steroids (cumulative 4 – 5 g) in combination with orbital irradiation in patients with impaired motility. In patients with insufficient therapeutic response after 6 weeks, treatment should be switched to other immunosuppressive agents. In severe sight-threatening disease, bony orbital decompression is usually necessary. As basic research has improved our understanding of the underlying pathophysiology of GO, it has been possible to develop targeted therapies for GO. Teprotumumab, an IGF-1 receptor antibody, was effective in treating GO patients in a phase III trial and should soon be awarded approval for Europe.
Conclusion The current therapy concept for Gravesʼ orbitopathy is as follows: first anti-inflammatory therapy then surgical correction of the permanent defects. This may soon be modified, due to the use of targeted therapies.
A Netnography and a Survey on Doping Use among Competitive Doping-untested Strength-sport Athletes
Authors: Jokipalo Iiro , Khudayarov Anna 
Published: January 2021

AbstractDoping-untested strength-sport athletes (powerlifters, strongmen, armlifters, etc.,) are infamous for their doping use, but their exact doping regimens are not known. The purpose of this study was to provide a reasonable portrait of doping history in this specific athlete group for medical practitioners. Seventy-five athletes were selected by netnography of the social media community around the Finnish doping-untested strength-sport federations on the basis of their activity in doping-related discussions, and the athletes were invited to answer a detailed doping-related anonymous survey. Fifty respondents completed the survey. 100% of the respondents reported use of anabolic androgenic steroids, 66% reported use of stimulants, and 80% use of non-steroidal anabolic substances. The doses of both testosterone products and human growth hormone were notably larger than reported in previous studies of gym users (mostly non-competitive athletes). The subjects reported simultaneous use of an average 5.66 illegal substances, and lifetime use of 16.78 illegal substances. The doses of illicit drugs, as well as polypharmacy, among competitive doping-untested strength-sport athletes are higher than previously reported among recreational gym users, and side effects are likely in this specific population.
Estimating Inert Gas Bubbling from Simple SCUBA Diving Parameters
Authors: Fichtner Andreas , Brunner Benedikt , Pohl Thomas , Grab Thomas , Fieback Tobias , Koch Thea 
Published: January 2021

AbstractInert gas bubbles frequently occur in SCUBA divers’ vascular systems, eventually leading to decompression accidents. Only in professional settings, dive profiles can be adjusted on individual basis depending on bubble grades detected through ultrasonography. A total of 342 open-circuit air dives following sports diving profiles were assessed using echocardiography. Subsequently, (Eftedal-Brubakk) bubble grades were correlated with dive and individual parameters. Post-dive cardiac bubbles were observed in 47% of all dives and bubble grades were significantly correlated with depth (r=0.46), air consumption (r=0.41), age (r=0.25), dive time (r=0.23), decompression diving (r=0.19), surface time (r=− 0.12). Eftedal-Brubakk categorical bubble grades for sports diving with compressed air can be approximated by bubble grade = (age*50−1 – surface time*150−1+maximum depth*45−1+air consumption*4500−1)2 (units in years, hours, meter, and bar*liter; R2=0.31). Thus, simple dive and individual parameters allow reasonable estimation of especially relevant medium to higher bubble grades for information on relevant decompression stress after ascent. Echo bubble grade 0 is overestimated by the formula derived. However, echo might fail to detect minor bubbling only. The categorical prediction of individual decompression stress with simple bio and dive data should be evaluated further to be developed towards dive computer included automatic ex-post information for decision-making on individual safety measures.
Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications
Authors: Ekiert Halina , Świątkowska Joanna , Klin Paweł , Rzepiela Agnieszka , Szopa Agnieszka 
Published: January 2021

AbstractArtemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in it and proving its antimalarial activities. The raw materials obtained from this species are Artemisiae annuae folium and Artemisiae annuae herba. The leaves are a raw material in the Chinese Pharmacopoeia and Vietnamese Pharmacopoeia. Both raw materials are in the International Pharmacopoeia published by the WHO. The main components of these raw materials are mainly specific sesquiterpene lactones, essential oil, flavonoids, coumarins, and phenolic acids. In traditional Asian medicine, the species is used, for example, in the treatment of jaundice and bacterial dysentery, as an antipyretic agent in malaria and tuberculosis, in the treatment of wounds and haemorrhoids, and in viral, bacterial, and autoimmune diseases. Professional pharmacological studies conducted today have confirmed its known traditional applications and explain previously unknown mechanisms of its biological action and have also found evidence of new directions of biological activity, including, among others, anti-inflammatory, analgesic, antioxidant, antitumour, and nephroprotective activities. The species is of growing importance in the cosmetics industry.
Homoeopathy—A Plausible Alternative Treatment of De Quervain's Tenosynovitis: Case Reports
Authors: Dixit Ashish Kumar 
Published: January 2021

Abstract
Background De Quervain's tenosynovitis (DQT) is a disorder characterised by pain on the radial side of the wrist, impairment of thumb function and thickening of the ligamentous structure covering the tendons in the first dorsal compartment in the wrist.
Methods Two patients—a 50-year-old housewife and a 43-year-old computer operator were treated with a homoeopathic medicine ‘Rhus toxicodendron’ prescribed in 1M potency. The assessment was done using a visual analogue scale (VAS) for pain, quality of life (QoL) and range of motion (ROM) at baseline and end of the treatment. Assessment of causal attribution of treatment effect was done with the Modified Naranjo Criteria.
Result Both the cases showed a marked reduction in VAS (from +8 to 0 for both cases) and increase in QoL (from +5 to +10 & from +7 to +9) and ROM. The Modified Naranjo Criteria total score for each case was +7/13.
Conclusion Homoeopathy can be an effective approach in the management of DQT. Randomised controlled trials are thus indicated.
Patient, Defect, and Surgical Factors Influencing Use of Ancillary Procedures after Facial Mohs Repairs
Authors: Neuner Romy A. , Sclafani Anthony P. , Minkis Kira , Obayemi Ade , Navrazhina Kristina , Cressey Brienne , Ojeda Sam , Trujillo Oscar 
Published: January 2021

AbstractThis article determines if patient, defect, and repair factors can be used to predict the use of additional treatments to achieve optimal aesthetic results after repair of facial Mohs defects. An electronic chart review of patients undergoing Mohs excision and reconstruction of facial neoplasms from November 2005 to April 2017 was performed, reviewing patient demographics and history, tumor size, defect size and location, method and service of reconstruction, time between resection and repair, complications, and subsequent treatments. A total of 1,500 cases with basal cell and squamous cell carcinoma were analyzed. The average defect size was 3.09 ± 8.06 cm2; 81.9% of defects were less than 4 cm2 in size. Advancement flaps were used to repair 44.3% of defects. Complications and undesired sequelae (CUS) were noted in 15.9% of cases; scar hypertrophy or keloid (10.8%) was most common. Postoperative ancillary procedures were performed in less than one-quarter (23.4%) of patients to enhance the postrepair appearance; the most common procedures were intralesional corticosteroid injections and pulse dye laser treatments. CUS were more likely in females (19.6%), defects on the lips (28.7%) and on the nose (27.3%) (p < 0.001 for each). Females (22.7% vs. 12.7%), lip repairs (40.2% vs. 18.3%), transposition flaps (39.2% vs. 14.8%), and repairs performed by a dermatologist (17.9% vs. 11.2%) (p < 0.001 for each) were more likely to be treated with postoperative corticosteroid injections. Females (14.5% vs. 7.4%), patients under the age of 60 years (13.9% vs. 8.8%), and patients whose repair was performed by a dermatologist (11.9% vs. 2.9%) (p < 0.001 for each) were more likely to receive postoperative pulsed dye laser treatments. CUS and ancillary procedures after repair of facial Mohs defects are uncommon. Awareness of individual risk factors and defect characteristics allows the surgeon to choose the most appropriate repair technique while anticipating the potential need for ancillary procedures.
Bell's Palsy Associated with SARS-CoV-2 Infection in a 2-Year-Old Child
Authors: Bsales Serina , Olson Birk , Gaur Sunanda , Chefitz Dalya , Carayannopoulos Mary , Uprety Priyanka , Esfahanizadeh Abdolreza 
Published: January 2021

AbstractBell's palsy (BP) is an acute, unilateral facial nerve palsy (FNP) that is a diagnosis of exclusion, sometimes associated with infectious causes. In this article, we described a previously healthy 2-year-old child patient who presented with left-sided facial droop, positive severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) real-time reverse transcription polymerase chain reaction (RT-PCR), positive SARS-CoV-2 immunoglobulin (Ig)-G antibody, and negative cerebrospinal fluid (CSF) SARS-CoV-2 (PCR and serology). This is the second reported pediatric case of BP in the setting of SARS-CoV-2, and the first in a child without comorbidities. Due to the positive antibody test, we presented the idea that SARS-CoV-2 could be a triggering factor of the FNP, possibly occurring in the later stages of disease.
Prehospital EMS Triage for Acute Stroke Care
Authors: Noorian Ali Reza 
Published: January 2021

AbstractAcute stroke has had major advances over the last two decades due to the introduction of pharmacologic and endovascular revascularization, which can improve functional outcome. Stroke systems of care have been developed to provide faster, more efficient care for stroke patients. A major part of these care pathways is prehospital care, when patients are triaged to appropriate levels of care. It is essential that prehospital scales are used accurately and effectively by emergency medical services to assist them with the triage process. New technologies including mobile stroke units, telemedicine, and wearable technology have been introduced as options for optimization of this emergent process.
Development of a type of differential switched oscillator system for the radiation of mesoband high-power electromagnetic pulses
Authors: Wang Shao-fei , Xie Yan-zhao , Zhu Zi-jun , Qiu Yang-xin 
Published: January 2021

In this Note, a type of Differential Switched Oscillator (DSWO) system is developed and compared with the conventional single-ended switched oscillator; the power capacity of the DSWO is twice with the same insulation level and twice total length. The DSWO system consists of a differential high-voltage pulsed source, a DSWO, and a pair of differential helical antennas. The differential pulsed source is based on the hydrogen thyratron and pulsed transformer whose peak voltage can theoretically reach ±100 kV to break down the high-pressure switch, whose limiting gas pressure is 25 atm; the DSWO is designed to generate a damped oscillation pulse with a central frequency of 300 MHz, which is also the central frequency of the differential helical antennas. Thus, a damped oscillation pulse can be produced and radiated to generate high-power mesoband circularly polarized electromagnetic fields, and the axial ratio is 1.98. According to the measured results, the central frequency of the developed DSWO is 284 MHz, the percent bandwidth of the radiating field is 11%, and the amplitude of the far-field effective potential is 105 kV.
Early phonetic learning without phonetic categories: Insights from large-scale simulations on realistic input
Authors: Schatz Thomas , Feldman Naomi H. , Goldwater Sharon , Cao Xuan-Nga , Dupoux Emmanuel 
Published: January 2021

SignificanceInfants become attuned to the sounds of their native language(s) before they even speak. Hypotheses about what is being learned by infants have traditionally driven researchers’ attempts to understand this surprising phenomenon. Here, we propose to start, instead, from hypotheses about how infants might learn. To implement this mechanism-driven approach, we introduce a quantitative modeling framework based on large-scale simulation of the learning process on realistic input. It allows learning mechanisms to be systematically linked to testable predictions regarding infants’ attunement to their native language(s). Through this framework, we obtain evidence for an account of infants’ attunement that challenges established theories about what infants are learning.
Characteristics of numerals and classifiers in Darmdo Minyag
Authors: Drolma Dawa , Daudey Henriëtte 
Published: January 2021

AbstractBased on first-hand data obtained during fieldwork, our article analyses numerals and frequently employed numeral classifiers of Darmdo Minyag. Numeral classifiers are obligated to follow a numeral when counting. There are three different roots for ‘ten’: /ɦa~ʁo/ used in the numbers 10–19; /ʁuɑ/ used in the numbers 20–49; and /ɡa/ used in the numbers 50–99. The presence of multiple roots for ‘ten’ with an initial glottal, uvular or velar stop or fricative has been attested in many languages of the Qiangic area. Although Tibetan forms may be used for all numerals, native forms up to 99 have been attested in Darmdo Minyag. The influence of Tibetan on cardinal and ordinal numerals, approximate, multiple and fractional numbers is noted as well. Darmdo Minyag has a rich inventory of sortal and mensural classifiers. Shape is the most important feature according to which nouns are categorized. Mensural classifiers may be divided into arrangement classifiers and units of measure. Units of measure are of two types: the first acts as a classifier, the second type is a [noun numeral+classifier] construction. Darmdo Minyag has two types of verbal action classifiers: several verbal action classifiers of unknown origin which modify semantically rich verbs, and numeral-verb combinations which modify a semantically empty verb. The main functions of classifiers are classification and individualization.
Lightlike geodesics and gravitational lensing in the spacetime of an accelerating black hole
Authors: Frost Torben C , Perlick Volker 
Published: January 2021

Abstract
The C-metric is a solution to Einstein’s vacuum field equation that describes an accelerating black hole. In this paper we discuss the propagation of light rays and the resulting lensing features in this metric. We first solve the lightlike geodesic equation using elliptic integrals and Jacobi elliptic functions. Then we fix a static observer in the region of outer communication of the C-metric and introduce an orthonormal tetrad to parameterise the directions of the light rays ending at the position of the observer using latitude-longitude coordinates on the observer’s celestial sphere. In this parameterisation we rederive the angular radius of the shadow, we formulate a lens equation, and we derive the redshift and the travel time of light rays. We discuss the relevance of our theoretical results for detecting accelerating black holes described by the C-metric and for distinguishing them from non-accelerating black holes.
Identification of critical nuclei in the rapid solidification via configuration heredity
Authors: Li Yuan , Peng Ping , Xu Dongsheng , Yang Rui 
Published: January 2021

Abstract
The identification and characterization of critical nuclei is a long-standing issue in the rapid solidification of metals and alloys. An ambiguous description for their sizes and shapes used to lead to an overestimation or underestimation of homogeneous nucleation rates

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T

in the framework of classical nucleation theory (CNT). In this paper, a unique method able to distinguish the critical nucleus from numerous embryos is put forward on the basis of configuration heredities of clusters during rapid solidifications. As this technique is applied to analyze the formation and evolution of various fcc-Al single crystal clusters in a large-scale molecular dynamics simulation system, it is found that the size n
c and geometrical configuration of critical nuclei as well as their liquid–solid interfacial structure can be determined directly. For the present deep super-cooled system with an undercooling of

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m

=
0.42

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m

c
a
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, the average size of critical nuclei is demonstrated to be

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c

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≈
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, but most of which are non-spherical lamellae. Also, their liquid–solid interfaces are revealed to be not an fcc-liquid duplex-phase interface but an fcc/hcp-liquid multi-phase structure. These findings shed some lights on the CNT, and a good agreement with previous simulations and experiments in

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indicates this technique can be used to explore the early-stage of nucleation from atomistic levels.