bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Stage Nasolabial Flap for Unilateral Nasal Ala and Soft Triangle Reconstruction
Authors: Aggarwal Krittika , Singh Kuldeep , Singh Bikramjit 
Published: March 2021

Introduction:
Nose is the most noticeable feature in the facial profile. Any deformity of nose causes social embarrassment and ridicule. Isolated nasal alar hypoplasia/cleft or traumatic loss is a rare anomaly which requires reconstruction. Congenital deficiency of soft triangle of nose and part of ala is not paid attention to in early childhood. Hence, most of these individuals present in late childhood, adolescence or adulthood. We report ten such cases and their reconstruction using two stage ipsilateral interpolated nasolabial flap.

Material and Methods:
Demographic data including age, sex, associated co-morbidities, previous surgeries or history of trauma were documented. Patients were in age group of 10-25 years. The mean size of defect was 1.5 X 1.6 cm. Inferiorly based skin flap raised from ala was turned down and used as inner lining. Conchal cartilage graft was placed for support in the first stage itself. Nasolabial flap was raised by subcutaneous dissection and insetting done to create outer cover. Second stage for pedicle detachement was done after 3 weeks.

Results:
Post operative period was uneventful in all cases. Minimal cosmetic morbidity was noted. Scar was well concealed in the nasolabial crease and colour match was also acceptable with good patient satisfaction at 6-12 months.

Conclusion:
Nasal alar hypoplasia/cleft, congenital or traumatic, is a rare entity which needs to be recognised and reconstructed. According to the size of the defect, it can be reconstructed with composite cartilage graft or local flaps. Interpolated nasolabial flap with cartilage graft is a good option with minimal scar and excellent patient satisfaction.
Parents’ Knowledge of Danger Signs and Health Seeking Behavior in Newborn and Young Infant Illness in Tiro Afeta District, Southwest Ethiopia: A Community-based Study
Authors: Berhane Melkamu , Yimam Hadiya , Jibat Nega , Zewdu Mesfin 
Published: March 2021

BACKGROUND: Neonatal mortality rates in Ethiopia are among the highest in the world. Reducing neonatal and young infant mortality highly relies on early recognition of symptoms and appropriate care-seeking behavior of parents/care givers. The main aim of this study was to assess the knowledge of danger signs and health seeking behavior of parents/care givers in newborn and young infant illness in Southwest Ethiopia.METHODS: A community-based cross-sectional study was conducted using cluster sampling technique to get 422 samples of parents/care givers who had infants of less than 6 month old. Data was collected through face-to-face interviews using structured questionnaire. Logistic regression was used to identify factors affecting care seeking behavior and knowledge of parents/care givers on newborn and young infant illness.RESULT: Care seeking behavior for newborn and young infant illness was high (83%), the major factor associated with care seeking behavior being place of delivery. Only less than half of the respondents had adequate knowledge of symptoms of illness of newborns and young infants. The major factors associated with knowledge of parents/care givers were maternal education and paternal education.CONCLUSIONS: To improve the knowledge of parents/care giversabout newborn and young infant illness, counseling about the major symptoms of newborn and young infant illness should be intensified.KEYWORDS: Neonatal illness, care seeking behavior, new born,knowledge
Gambaran Tingkat Pengetahuan Swamedikasi Obat Analgesik Pada Mahasiswa-Mahasiswi Universitas Tadulako Di Kota Palu
Authors: Irawati Rini , Rumi Amelia , Parumpu Firdawati Amir 
Published: March 2021

Swamedikasi merupakan usaha seseorang dalam menolong dirinya sendiri berupa mengobati dirinya sendiri. Dalam menjalankannya, swamedikasi bisa menjadi masalah terkait obat (Drug related problem) karena pengetahuan yang terbatas mengenai obat dan penggunaannya. Analgesik merupakan obat yang berkhasiat untuk mengurangi atau menghilangkan rasa nyeri atau obat-obat yang digunakan untuk menghilangkan rasa sakit tetapi tidak menghilangkan kesadaran. Tujuan dari penelitian ini adalah mengetahui bagaimana gambaran tingkat pengetahuan swamedikasi obat analgesik pada mahasiswa Kesehatan dan Non Kesehatan Universitas Tadulako di Kota Palu. Penelitian ini menggunakan metode non eksperimental (observasional) dan bersifat cross sectional, dengan metode survei menggunakan kuesioner yang disebar melalului google form dengan jumlah mahasiswa kesehatan 349 responden dan mahasiswa Non kesehatan 396 responden. Teknik dalam pengambilan sampel yang digunakan pada penelitian ini yaitu purposive sampling. Hasil pengolahan data didapatkan hasil penelitian pengetahuan mahasiswa Kesehatan pada kategori baik sebesar 47,28 %, %, kategori cukup sebesar 49,28 % dan kategori kurang 3,44 %. Sedangkan pengatahuan mahasiswa non Kesehatan masuk kedalam kategori baik sebesar 16,16 %, ketegori cukup sebanyak 72,98 % dan kategori kurang sebanyak 10,86 %. Hasil uji mann-whitney diperoleh nilai signifikansi < 0,05 (0,00 < 0,05) maka hasil tersebut menunjukkan terdapat perbedaan yang signifikan antara tingkat pengetahuan mahasiswa Kesehatan dan Non Kesehatan. Kesimpulan mahasiswa kesehatan dan non kesehatan universitas tadulako memiliki tingkat pengetahuan yang cukup dan mahasiswa Kesehatan memiliki pengetahuan yang lebih baik dibandingkan mahasiswa non Kesehatan
Faktor – Faktor Determinan Kejadian Servisitis Di Dki Jakarta Tahun 2017-2019
Authors: Susanty Frides , Bantas Krisnawati 
Published: March 2021

Tujuan untuk mengetahui besarnya masalah servisitis dan determinan kejadian servisitis pada peserta Female Cancer programme (FcP) di DKI Jakarta. Metode desain potong lintang dan data sekunder bersumber dari data pemeriksaan IVA Female Cancer programme (FcP) di DKI Jakarta tahun 2017-2019. Jumlah sampel 3378 orang, Variabel-variabel yang diteliti adalah servisitis (dependen), dan sebagai variabel independennya adalah, metode penggunaan kontrasepsi, paritas, usia, indeks massa tubuh, usia pertama kontak seksual, status merokok, frekuensi menikah responden, frekuensi menikah suami responden, tingkat pendidikan responden, riwayat keguguran. Analisis univariat mendeskripsikan frekuensi dan distribusi dari variabel yang diteliti, analisis bivariat dan multivariat yang digunakan regresi logistik. Hasil penelitian menunjukkan prevalensi servisitis 11,13% dan faktor-faktor yang berhubungan dengan kejadian servisitis adalah faktor metode penggunaan kontrasepsi dan faktor usia. Dibandingkan dengan kelompok yang tidak menggunakan alat kontrasepsi, kelompok yang menggunakan metode kontrasepsi hormonal mempunyai prevalen odds kejadian sevisitis 1,593 kali lebih tinggi (POR 1,593; 95% CI 1,244-2,040), sementara pada kelompok yang menggunakan metode kontrasepsi non-hormonal mempunyai prevalen odds kejadian servisitis yang tidak berbeda dengan kelompok yang tidak menggunakan alat kontrasepsi (POR 0,832; 95% CI 0,616-1,22). Dibandingkan dengan kelompok umur >51 tahun, kelompok usia 30-39 mempunyai prevalen odds kejadian servisitis 2,107 kali lebih tinggi (POR 2,017; 95% CI 1,312-3,383), kelompok usia 40-50 tahun mempunyai prevalen odds kejadian servisitis 2,203 kali lebih tinggi (POR 2,203; 95% CI 1,379-3,518). Sementara itu tidak ada perbedaan prevalen odds kejadian servisitis pada kelompok usia <30 dan kelompok usia > 51 tahun. Kesimpulan: Prevalensi servisitis 11,13% dan faktor-faktor determinan terjadinya servistis pada pemeriksaan IVA FcP di DKI Jakarta tahun 2017-2019 adalah faktor metode kontrasepsi hormonal dan faktor usia
Synergistic effects of ivabradine and metformin in the treatment of concomitant chronic heart failure and diabetes mellitus by regulating the activity of the H19/miR-423-5p/HCN4 axis
Authors: Zhang Fang , Jiang Weijun , Liu Yating , Li Liu , Wang Rui , Li Yang 
Published: March 2021

IntroductionIn this study, the molecular mechanisms underlying the therapeutic effect of metformin (MET) and ivabradine (IBD) in the treatment of concomitant chronic heart failure (CHF) and diabetes mellitus (DM) were investigated.Material and methodsBasic and cardiac indexes were measured to study the therapeutic effect of MET and IBD. Real-time PCR, IHC assays, in-silicon analysis, luciferase assays, real-time PCR and Western blot assays were conducted to clarify the molecular mechanisms underlying the interaction between MET and IBD.ResultsMET administration restored the normal values of general/cardiac indexes in CHF rats. The abnormal values of echocardiographic indexes in CHF rats with STZ-induced DM were all corrected by a certain degree after the MET administration. Moreover, the injection of STZ up-regulated the expression of plasma NE/BNP-45, while the IBD administration reduced the levels of NE/BNP-45 in CHF rats. Furthermore, the administration of MET also reduced the NE level in CHF rats, indicating that both MET and IBD can exert a therapeutic effect on CHF rats. Additionally, in-silicon analysis and luciferase assays verified the role of H19 and HCN4 as target genes of miR-423-5p. In fact, the transfection of MET or H19 siRNA1/2 into HL-1 and H9C2 cells down-regulated the levels of H19 and HCN4 while increasing the level of miR-423-5p.ConclusionsMET reduces H19 expression via inducing methylation of its promoter, and the inhibited H19 expression suppresses HCN4 expression by up-regulating miR-423-5p expression. As a result, the suppressed expression of HCN4 reduces heart rate and exhibits a therapeutic effect in the treatment of concomitant CHF and DM.
H2S alleviates Parkinson-like phenotypes by modulating lncRNA-CasC7/miR-30c/BNIP3L signaling pathway
Authors: Long Ling , Cai Xiaodong , Liao Jinchi , Ma Xiaomeng , Liu Yingying , Huang Yiying , Liu Xu , Chen Xiaohong 
Published: March 2021

IntroductionThe pathogenesis of Parkinson’s disease (PD) is closely related to mitophagy, a process regulated by miRNAs and long non-coding RNAs (lncRNAs). In this study, we investigated the role of the lncRNA-CasC7/miR-30c/BNIP3L (BCL2 Interacting Protein 3 Like) signaling pathway in PD.Material and methodsA 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD was generated and treated by hydrogen sulfide (H2S) inhalation. The SH-SY5Y cell model of PD was generated by MPP+ and the treatment was NaHS. The open field, rotarod and tail suspension tests were performed to assess motor deficits. TUNEL and immunofluorescence assays were used to evaluate neuronal apoptosis in mice and in SH-SY5Y cell culture. Real-time PCR was performed to measure the expression level of the lncRNA-CasC7, miR-30c and BNIP3L, and western blotting was used to assess the protein levels of CBS, BNIP3L and PINK1. Luciferase assays were conducted to examine the regulatory relationship between miR-30c and lncRNA-CasC7/BNIP3L.ResultsH2S inhalation alleviated the motor disorder and neuronal apoptosis in PD mice, and NaHS treatment inhibited apoptosis in the SH-SY5Y cell culture model of PD. The sulfide compounds also ameliorated the dysregulated expression of CasC7, miR-30c, BNIP3L, and PINK1 in the PD models. Furthermore, miR-30c significantly inhibited the expression of lncRNA-CasC7 and BNIP3L, as assessed with the luciferase assays.ConclusionsOur findings suggest that the lncRNA-CasC7/miR-30c/BNIP3L mitophagy signaling pathway is involved in the pathogenesis of PD.
AnnexinA7 and CAP1 are associated with regulating tumor cell adhesion molecule expression and biological behavior
Authors: Wang Li , Wang Yang , Liu Zhiyan , Zhou Yixia , Zhang Jun , Tang Jianwu 
Published: March 2021

IntroductionTo find out the correlations between the effects of down-regulating AnnexinA7 and CAP1 gene on cell adhesion factors and the biological behavior of Hca-p cells cells, and finally infer the relationship between the two genes.Material and methodsWestern blot ,qRT-PCR,immunocytochemistry, CCK8 cell proliferation, flow cytometry, lymph node adhesion and transwell chamber assay testing .ResultsAnnexinA7 and CAP1 were consistent with the regulation of the expression of the adhesion molecules such as FAK, Src, Paxillin and E-cadherin. At the mRNA and protein levels, the expression of FAK, Src and Paxillin were increased with down-regulated AnnexinA7 and CAP1 genes, while E-cadherin was down-regulated in the change of these two genes. And the low expression of AnnexinA7 could affect the expression of CAP1 in mRNA and protein levels. otherwise, the localization of AnnexinA7 and CAP1 in hepatocellular carcinoma cells was also the same. After down-regulating the expression of CAP1, the functions of proliferation, lymph node adhesion and invasion were increased and early apoptotic ability was decreased in Hca-P cells.ConclusionsAnnexinA7 and CAP1 could control the expression of these adhesion molecules in the same trend. We speculated they may be co-localization. And AnnexinA7 gene may be related to the molecular mechanism of CAP1 gene, which is likely to have a consistent effect on cell adhesion molecules and be closely related to the biological behaviors of Hca-P cells.AnnexinA7 and CAP1 may play an inhibitory role in lymph node metastasis to provide a reliable basis for the early identification of lymphatic metastasis in hepatocellular carcinoma.
Publicidad institucional y pluralismo informativo
Authors: Magallón Rosa Raul 
Published: March 2021

Esta investigación analiza el papel en España de la Administración General del Estado a la hora de establecer el reparto de la publicidad institucional así como de las campañas comerciales desde la aprobación de la Ley de Publicidad Institucional de 2005. Además de los cambios de gobierno, hay escenarios políticos y económicos que también condicionan el desarrollo y ejecución de los planes de publicidad institucional. La caída de la inversión en publicidad institucional ha sido muy importante en términos generales y en todos los medios publicitarios en la última década, menos en Internet, que se ha mantenido mejor.
Por otra parte, entre 2006 y 2018 el presupuesto destinado a campañas comerciales ha aumentado en 10 millones de euros, un 10,42%. Sin embargo, el presupuesto destinado a la comunicación y publicidad institucional se ha reducido un 89,76% y más de 188 millones de euros
Improved machine-learning-based open-water–sea-ice–cloud discrimination over wintertime Antarctic sea ice using MODIS thermal-infrared imagery
Authors: Paul Stephan , Huntemann Marcus 
Published: March 2021

Abstract. The frequent presence of cloud cover in polar regions limits the use of the Moderate Resolution Imaging Spectroradiometer (MODIS) and similar instruments for the investigation and monitoring of sea-ice polynyas compared to passive-microwave-based sensors. The very low thermal contrast between present clouds and the sea-ice surface in combination with the lack of available visible and near-infrared channels during polar nighttime results in deficiencies in the MODIS cloud mask and dependent MODIS data products. This leads to frequent misclassifications of (i) present clouds as sea ice or open water (false negative) and (ii) open-water and/or thin-ice areas as clouds (false positive), which results in an underestimation of actual polynya area and subsequently derived information. Here, we present a novel machine-learning-based approach using a deep neural network that is able to reliably discriminate between clouds, sea-ice, and open-water and/or thin-ice areas in a given swath solely from thermal-infrared MODIS channels and derived additional information. Compared to the reference MODIS sea-ice product for the year 2017, our data result in an overall increase of 20 % in annual swath-based coverage for the Brunt Ice Shelf polynya, attributed to an improved cloud-cover discrimination and the reduction of false-positive classifications. At the same time, the mean annual polynya area decreases by 44 % through the reduction of false-negative classifications of warm clouds as thin ice. Additionally, higher spatial coverage results in an overall better subdaily representation of thin-ice conditions that cannot be reconstructed with current state-of-the-art cloud-cover compensation methods.
A Educação Infantil no contexto da pandemia: os possíveis enfrentamentos após a publicação do Parecer 05/2020
Authors: Magalhães Cassiana , Dos Santos Farias Cristiane 
Published: March 2021

O presente artigo pretende discutir o Parecer 05/2020 do Conselho Nacional de Educação (CNE) e os possíveis enfrentamentos no contexto da Educação Infantil. A questão orientadora foi delineada da seguinte forma: como a Educação Infantil é afetada pela pandemia da COVID-19? A questão se faz necessária pela garantia dos direitos conquistados duramente no campo da educação das crianças, especialmente ao fato de serem educadas em espaços coletivos, não domésticos (BRASIL, 2009), e agora na possibilidade de realização de atividades a distância, especialmente na modalidade EAD, por meio de videoaulas e outros recursos virtuais para crianças pequenas, o que pode demarcar ainda mais as condições de desigualdade social. A composição da escrita é de cunho bibliográfico e os resultados encaminham para a necessidade de enfrentamento por meio da resistência, o que não significa abandonar as crianças em tempos de pandemia, ao contrário, é necessário criar as formas mais adequadas de atendê-las.
PERANCANGAN DAN PEMBUATAN COMBINATION DIES PRODUK WALL BRACKET UNTUK TOWEL BAR
Authors: Kumbarasari Shanti , Nugroho Theodorus Argo , Dewata Amadea Widi , Krisstyoko David Hendra , Suryana Erwin , Priyadi Laksana Ari Hadi , Wibowo Eko Sulistyo 
Published: March 2021

Untuk pemenuhan kebutuhan proyek bangunan skala apapun, target waktu yang relative cepat maka diperlukan kerja sama pada subcont penyedia pelengkap proyek bangunan. Bagian sanitasi merupakan kelengkapan interior bangunan, salah satu komponen bagian sanitasi adalah towel bar. Wall bracket yang menjadi bagian towel bar selama ini metode pembuatannya menggunakan mesin bubut manual 1 pcs wall bracket membutuhkan waktu 2 jam. Agar ketersediaan produk towel bar terutama wall bracket dapat tepat waktu, bentuk produk konsisten maka diperlukan inovasi dalam metode pembuatannya yaitu salah satunya menggunakan metode combination dies untuk meningkatkan produksi dan memenuhi permintaan 200 pcs/bulan. Agar mendapatkan produk wall bracket dengan dimensi diameter luar 33.1 mm, tinggi, diameter dalam 3.5 mm, tinggi 8 mm, sudut 82odengan ketebalan 2 mm dengan metode pengerjaan combination dies pada mesin Nagao 110 Ton ditentukan oleh ukuran punch atau drawing die yang tepat, sistem knock out, perhitungan stroke yang tepat sehingga produk tidak menempel pada dies. Pembuatan produk wall bracket pada towel bar dengan metode dies combination dapat mempersingkat waktu proses permesinan dan setiap produk yang dihasilkan dapat lebih dari satu produk disesuaikan dengan kapasitas mesin stamping.
PENDIDIKAN POLITEKNIK DI ERA DISRUPSI TEKNOLOGI DAN REVOLUSI INDUSTRI 4:0
Authors: Toyipur Toyipur 
Published: March 2021

Sistem pembelajaran di Politeknik mayoritas menggunakan sistem Blended Learning (campuran) tatap muka, praktek kerja dan online dengan komposisi pembelajaran ; 40% teori dan 60% praktik dengan mekanisme keterkaitan dan kecocokan (Link and match) Industry. Untuk mencapai keterkaitan dan kecocokan (Link and match) Industri diperlukan kebijakan komprehensif antar kementerian untuk menetapkan jabatan fungsional Pengembang Teknologi Pembelajaran (PTP) sebagai pelaksana terintegrasi program pembelajaran di perguruan tinggi khususnya Politeknik baik aneka sumber belajar, metode, bahan ajar, media atau lingkungan belajar sehingga outcome pembelajaran dapat meningkatkan produksi barang maupun jasa secara cepat, efektif dan efesian melalui pembelajaran yang bermakna, menyenangkan. Metode yang digunakan dalam penelitian adalah ”deskriptif kuantitatif” karena bersifat menjabarkan, menguraikan, dan menafsirkan kondisi, peristiwa, proses yang sedang terjadi dalam konteks permasalahan Penelitian ini dimaksudkan untuk mengeksplorasi dan klarifikasi mengenai suatu fenomena atau kenyataan sosial dengan jelas. Mendeskripsikan variabel yang berkenan dengan masalah dan unit yang diteliti. Metode pembelajaran sistem daring dan konvensional atau blended learning memungkinkan outcome SDM mempunyai kemampuan mengatasi disrupsi teknologi, pada sisi lain harapan Presiden dan Menristekdikti bahwa kemampuan menghadapi revolusi industri 4.0 dalam persaingan era disrupsi teknologi dan globalisasi tidak hanya melalui kemampuan khusus yang diperoleh karena menyelesaikan pendidikan magister S2, magister S3 pendidikan tinggi yang katanya menghasilkan kemampuan responsive keterlibatan industri 4.0 tetapi melalui perbaikan budaya pembelajaran. Indikator 0.033% SDM yang berkarier sebagai Pengembang Teknologi Pembelajaran di perguruan tinggi menunjukkan rendahkan perhatian perguruan tinggi dalam pengembangan program pembelajaran baik pengelolaan aneka sumber belajar, metode, media, bahan ajar dan lingkungan belajar sesuai kebutuhaan pembelajaran yang bermakna dan menyenangkan, hal ini disebabkan oleh ego profesi, ego sektoral
Hayek, las ciencias y la praxeología
Authors: Santoro Luis Luque 
Published: March 2021

This paper includes the main conclusions driven from a thorough com-pilation and interpretation of F.A. Hayek’s most relevant views on the subjects of philosophy of science, epistemology and methodology regarding social scien-ces. The dialogue that Hayek seems to establish between sciences and methods is particularly highlighted. This dialogue might be summarized in two ways: a «bottom-up» connection, by offering an alternative justification for methodologi-cal dualism and the proper methodological principles for the social sciences, from the perspetive of the natural sciences methodological paradigm in which Hayek frames his human mind theory in his work The Sensory Order; and a «top-down» connection, by concluding with respect to the complex phenomena theo-ries of natural sciences that there exist common methodological challenges with the social sciences, which require in both cases to take into account methodolo-gical differences not covered under the orthodox mainstream methodological paradigm. In this sense an interpretation of Hayek’s methodological approxima-tion to economics as an applied or empirical social science is proposed; which intends to offer explanations about concrete reality, as a necessary complement of Mises praxeology which instead only focuses on pure and formal theory.
Keywords: Hayek; Philosophy of Science; Methodology; Praxeology; Pure Logic of Choice.
JEL Classification: A12, A14, B41, B53.
Resumen: En este trabajo se presentan las principales conclusiones de una detenida compilación e interpretación de los planteamientos más importantes de F.A. Hayek sobre temas de filosofía de la ciencia, epistemología y metodo - logía de las ciencias sociales. En particular se resalta el diálogo que Hayek parece plantear entre ciencias y métodos y que se concretaría en dos senti-dos: en una conexión «por abajo», justificando el dualismo metodológico y los principios metodológicos adecuados para las ciencias sociales, desde el paradigma metodológico de las ciencias naturales en el que elabora su teoría sobre la mente humana en El Orden Sensorial; y en una conexión «por arriba» al concluir respecto a las teorías sobre fenómenos complejos de las ciencias naturales la existencia de retos comunes con los que también se enfrentan las ciencias sociales y que requieren dar cabida en ambos casos a diferencias metodológicas no previstas según el criterio ortodoxo dominante. En este último sentido, se propone una interpretación de la aproximación metodoló-gica de Hayek para la economía como una ciencia social aplicada o empí-rica que tiene como objetivo ofrecer explicaciones de la realidad, como el complemento necesario a la praxeología misesiana centrada en la teoría pura formal.
Palabras clave: Hayek; Filosofía de la Ciencia; Metodología; Praxeología; Lógica Pura de la Elección.
Clasificación JEL: A12 (Relación de la economía con otras disciplinas); A14 (Sociología de la economía); B41 (Metodología económica); B53 (Escuela aus-triaca).