bluuebunny/crossref_metadata_2025_split huggingface dataset:
European clinical practice recommendations on opioids for chronic noncancer pain – Part 2: Special situations*
Authors: Krčevski Škvarč Nevenka , Morlion Bart , Vowles Kevin E. , Bannister Kirsty , Buchsner Eric , Casale Roberto , Chenot Jean‐François , Chumbley Gillian , Drewes Asbjørn Mohr , Dom Geert , Jutila Liisa , O'Brien Tony , Pogatzki‐Zahn Esther , Rakusa Martin , Suarez–Serrano Carmen , Tölle Thomas , Häuser Winfried 
Published: March 2021

AbstractBackgroundOpioid use for chronic non‐cancer pain (CNCP) is under debate. In the absence of pan‐European guidance on this issue, a position paper was commissioned by the European Pain Federation (EFIC).MethodsThe clinical practice recommendations were developed by eight scientific societies and one patient self‐help organization under the coordination of EFIC. A systematic literature search in MEDLINE (up until January 2020) was performed. Two categories of guidance are given: Evidence‐based recommendations (supported by evidence from systematic reviews of randomized controlled trials or of observational studies) and Good Clinical Practice (GCP) statements (supported either by indirect evidence or by case‐series, case–control studies and clinical experience). The GRADE system was applied to move from evidence to recommendations. The recommendations and GCP statements were developed by a multiprofessional task force (including nursing, service users, physicians, physiotherapy and psychology) and formal multistep procedures to reach a set of consensus recommendations. The clinical practice recommendations were reviewed by five external reviewers from North America and Europe and were also posted for public comment.ResultsThe European Clinical Practice Recommendations give guidance for combination with other medications, the management of frequent (e.g. nausea, constipation) and rare (e.g. hyperalgesia) side effects, for special clinical populations (e.g. children and adolescents, pregnancy) and for special situations (e.g. liver cirrhosis).ConclusionIf a trial with opioids for chronic noncancer pain is conducted, detailed knowledge and experience are needed to adapt the opioid treatment to a special patient group and/or clinical situation and to manage side effects effectively.SignificanceIf a trial with opioids for chronic noncancer pain is conducted, detailed knowledge and experience are needed to adapt the opioid treatment to a special patient group and/or clinical situation and to manage side effects effectively. A collaboration of medical specialties and of all health care professionals is needed for some special populations and clinical situations.
Horizons for Modern Electrochemistry Related to Energy Storage and Conversion, a Review
Authors: Malka David , Attias Ran , Shpigel Netanel , Malchick Fyodor , Levi Mikhael D. , Aurbach Doron 
Published: March 2021

AbstractThe purpose of this paper is to suggest frontier inter‐disciplinary research directions that can be considered as important horizons of modern electrochemistry in the field of energy storage and conversion. We selected several topics that call for advancements in solid‐state, interfacial, analytical and energy‐related electrochemical science. A dramatic improvement in the performance of energy storage and conversion devices is needed to meet the urgent demands of our society. Significantly more efficient devices are needed to meet two major challenges: electro‐mobility, namely electrochemical propulsion of electric vehicles, and the ability to store and convert large quantities of energy generated from sustainable sources such as sun and wind. We suggest promotion of breakthroughs in several important directions. The examples chosen include: Development of novel in‐situ methodologies for design and testing composite electrodes for advanced energy storage devices; Improving the electrochemical performance of high specific capacity, but hard to control, LiNiO2 cathodes for advanced lithium ion batteries designed for electric vehicles, with a quantitative goal of stable specific capacity >230 mAh/g with a charging potential lower than 4.3 V; Advancing aqueous electrochemical systems for large energy storage based on sodium electrochemistry; Promoting development of batteries based on multivalent active metals with magnesium as the most advanced example. There is a strong incentive to promote fundamental and practical progress in the field of rechargeable Mg batteries using new electrodes’ configurations and advanced electroanalytical methods. All these directions require deep efforts in basic, fundamental studies, in order to reach important practical goals.
By Endowing Polyglutamic Acid/Polylysine Composite Hydrogel with Super Intrinsic Characteristics to Enhance its Wound Repair Potential
Authors: Wei Ran , Chen Taijun , Wang Yingying , Xu Qizhen , Feng Bo , Weng Jie , Peng Wenzhen , Wang Jianxin 
Published: March 2021

AbstractIn this study, multifunctional porous composite hydrogels are prepared via composite technology and using poly(glutamic acid) and (polylysine) as precursors, casein as foaming agent, and calcium ions as coagulant. The results show that the as‐prepared hydrogels have high porosity and water absorbency, and good mechanical, inherent antibacterial, and bioadhesive properties. The results show such high water absorption, bioadhesion, and porosity of the as‐prepared hydrogel can effectively concentrate blood components and seal wounds better. The release of calcium ions in the as‐prepared hydrogels can activate coagulation factors. Both factors can play an important role in hemostasis. The excellent hydroscopicity, moisture retention, adhesion, and inherent antibacterial properties of the as‐prepared hydrogel can create a moist, sterile, and closed microenvironment for the wound healing. The experimental results of a deep skin defect model have verified its good effect of promoting wound repair. These inherent excellent properties can endow the as‐prepared hydrogel with a wide range of application values.
State of the art in cystic fibrosis pharmacology optimization of antimicrobials in the treatment of cystic fibrosis pulmonary exacerbations: III. Executive summary
Authors: Epps Quovadis J. , Epps Kevin L. , Young David C. , Zobell Jeffery T. 
Published: March 2021

AbstractAcute pulmonary exacerbations are complications of cystic fibrosis (CF) and are associated with increased morbidity and mortality. Methicillin‐resistant Staphylococcus aureus (MRSA) and Aspergillus fumigatus are organisms that have been detected in the lungs of CF patients. The focus of this review is to provide an overview of the classes of antimicrobials used for MRSA and allergic bronchopulmonary aspergillosis (ABPA), a hypersensitivity reaction caused by A. fumigatus. The current anti‐MRSA antibiotics and medications for ABPA dosing recommendations are discussed. This article also reviews the findings from the MRSA utilization surveys and the pharmacokinetic and pharmacodynamic differences between CF and non‐CF patients. Antimethicillin S. aureus antibiotics include ceftaroline, clindamycin, fluoroquinolone derivatives (ciprofloxacin, levofloxacin), glycopeptide derivatives (telavancin, vancomycin), linezolid, rifampin, sulfamethoxazole/trimethoprim, and tetracycline derivatives (doxycycline, minocycline, tigecycline). Medications used for ABPA include corticosteroids, amphotericin B, azole antifungals (isavuconazole, itraconazole, posaconazole, voriconazole), and a monoclonal antibody, omalizumab.
Can the Evidence Revolution and Multi‐Tiered Systems of Support Improve Education Equity and Reading Achievement?
Authors: Fien Hank , Chard David J. , Baker Scott K. 
Published: March 2021

ABSTRACTWe situate education, and the science of reading (SOR) specifically, in the midst of a broad, evidence‐based revolution involving an array of disciplines focused on improving the health and well‐being of individuals and populations. Low and stagnant levels of reading proficiency, massive reading disparities, and a robust SOR knowledge base suggest that the withholding of evidence‐based practices in schools differentially harms students of Color, students from poor families, English learners, and students with disabilities. We acknowledge that simply expecting greater use of evidence‐based reading practices in schools will not suffice. We present a framework where practitioners and policymakers would continue to gain better and easier access to the SOR knowledge base and evidence‐based reading practices and where much greater emphasis would be placed on fueling the demand for evidence‐based practices in schools. How schools are organized to provide reading instruction for students is also a key consideration in efforts to expand the use of evidence‐based practices. We make the case that schools engaged in comprehensive use of multi‐tiered systems of support approaches in reading are well positioned to increase their use of evidence‐based reading practices. Because much is not known about how to scale the use of effective practices, scaling efforts themselves represent opportunities to generate new SOR knowledge on both the supply and demand sides. This work would be consistent with the SOR knowledge base as a dynamic and constantly emerging phenomenon, rather than a static repository waiting to be accessed and used.
Beyond Protection: The Role of the Home State in Modern Foreign Investment Law
Authors: Gazzini Tarcisio 
Published: March 2021

AbstractThe chapter examines the evolution of the role of the home state in foreign investment law. Traditionally, such a role was essentially limited to norm-setting and protecting nationals and national companies abroad. Protection was typically offered through diplomatic protection, which was based on the legal fiction that the state was vindicating its own right. The conclusion of modern investment treaties, the progressive emancipation of foreign investors and the development of investor-state arbitration meant a marginalisation of the home state. Some recent treaties, however, have paved the way for a new role for the home state that goes well beyond protection of its nationals and national companies. Innovative provisions have introduced obligations and responsibilities for the home state, especially with regard to the fight against corruption and the liability of its own investors. It remains to be seen to which extent these provisions will spread across the international community of states.
Spectral form factor in the double-scaled SYK model
Authors: Khramtsov Mikhail , Lanina Elena 
Published: March 2021

Abstract
In this note we study the spectral form factor in the SYK model in large q limit at infinite temperature. We construct analytic solutions for the saddle point equations that describe the slope and the ramp regions of the spectral form factor time dependence. These saddle points are obtained by taking different approaches to the large q limit: the slope region is described by a replica-diagonal solution and the ramp region is described by a replica-nondiagonal solution. We find that the onset of the ramp behavior happens at the Thouless time of order q log q. We also evaluate the one-loop corrections to the slope and ramp solutions for late times, and study the transition from the slope to the ramp. We show this transition is accompanied by the breakdown of the perturbative 1/q expansion, and that the Thouless time is defined by the consistency of extrapolation of this expansion to late times.
The Laplacian on Cartesian products with mixed boundary conditions
Authors: Seelmann Albrecht 
Published: March 2021

AbstractA definition of the Laplacian on Cartesian products with mixed boundary conditions using quadratic forms is proposed. Its consistency with the standard definition for homogeneous and certain mixed boundary conditions is proved and, as a consequence, tensor representations of the corresponding Sobolev spaces of first order are derived. Moreover, a criterion for the domain to belong to the Sobolev space of second order is proved.
Anodal tDCS modulates specific processing codes during conflict monitoring associated with superior and middle frontal cortices
Authors: Adelhöfer Nico , Stock Ann-Kathrin , Beste Christian 
Published: March 2021

AbstractConflict monitoring processes are central for cognitive control. Neurophysiological correlates of conflict monitoring (i.e. the N2 ERP) likely represent a mixture of different cognitive processes. Based on theoretical considerations, we hypothesized that effects of anodal tDCS (atDCS) in superior frontal areas affect specific subprocesses in neurophysiological activity during conflict monitoring. To investigate this, young healthy adults performed a Simon task while EEG was recorded. atDCS and sham tDCS were applied in a single-blind, cross-over study design. Using temporal signal decomposition in combination with source localization analyses, we demonstrated that atDCS effects on cognitive control are very specific: the detrimental effect of atDCS on response speed was largest in case of response conflicts. This however only showed in aspects of the decomposed N2 component, reflecting stimulus–response translation processes. In contrast to this, stimulus-related aspects of the N2 as well as purely response-related processes were not modulated by atDCS. EEG source localization analyses revealed that the effect was likely driven by activity modulations in the superior frontal areas, including the supplementary motor cortex (BA6), as well as middle frontal (BA9) and medial frontal areas (BA32). atDCS did not modulate effects of proprioceptive information on hand position, even though this aspect is known to be processed within the same brain areas. Physiological effects of atDCS likely modulate specific aspects of information processing during cognitive control.
New cell delivery system CellSaic with adipose-derived stromal cells promotes functional angiogenesis in critical limb ischemia model mice
Authors: Tanioka Hideki , Miyagawa Shigeru , Mori Daisuke , Watanabe Ken-ichi , Ueno Takayoshi , Toda Koichi , Shibuya Takashi , Kuratani Toru , Sawa Yoshiki 
Published: March 2021

AbstractCurrent therapies for patients with critical limb ischemia have not reduced amputation risk owing to poor cell engraftment. The recombinant peptide Cellnest increases the engraftment rate of administered cells by forming a complex with the cells (CellSaic). We hypothesized that CellSaic containing adipose-derived stromal cells (ADSCs) could improve lower limb blood flow better than ADSCs alone, resulting in better transplanted cell engraftment. ADSCs were extracted from 8-week-old C57BL/6N mice. Thirty-two critical limb ischemia model mice were established by ligating femoral arteries. They were divided into CellSaic (n = 11), ADSC (n = 10), saline (n = 9), and Cellnest (n = 9) groups. Blood flow rate (affected side blood flow / healthy side blood flow × 100%) was evaluated using a laser Doppler blood flow meter every week. Mice were euthanized on day 28 for histological evaluation. Compared with the ADSC group (54.5 ± 17.2%), treated side blood flow rate of the CellSaic group (78.0 ± 24.9%) showed significant improvement on day 28 after administration (p < 0.05). CD31 staining showed significantly higher number of capillary vessels in the CellSaic group (53.0 ± 8.9 cells/mm3) than in the ADSC group (43.0 ± 6.8 cells/mm3) (p < 0.05). Fluorescent staining showed significantly higher number of arterioles containing both CD31 and αSMA double-positive cells in the CellSaic group than in the ADSC group (p < 0.05). CellSaic containing ADSCs exhibited superiority to ADSC transplantation alone in promoting functional angiogenesis, suggesting its potential in improving clinical outcomes of angiogenic therapy for ischemic limbs.
Real-time GNSS precise point positioning for low-cost smart devices
Authors: Wang Liang , Li Zishen , Wang Ningbo , Wang Zhiyu 
Published: March 2021

AbstractGlobal Navigation Satellite System raw measurements from Android smart devices make accurate positioning possible with advanced techniques, e.g., precise point positioning (PPP). To achieve the sub-meter-level positioning accuracy with low-cost smart devices, the PPP algorithm developed for geodetic receivers is adapted and an approach named Smart-PPP is proposed in this contribution. In Smart-PPP, the uncombined PPP model is applied for the unified processing of single- and dual-frequency measurements from tracked satellites. The receiver clock terms are parameterized independently for the code and carrier phase measurements of each tracking signal for handling the inconsistency between the code and carrier phases measured by smart devices. The ionospheric pseudo-observations are adopted to provide absolute constraints on the estimation of slant ionospheric delays and to strengthen the uncombined PPP model. A modified stochastic model is employed to weight code and carrier phase measurements by considering the high correlation between the measurement errors and the signal strengths for smart devices. Additionally, an application software based on the Android platform is developed for realizing Smart-PPP in smart devices. The positioning performance of Smart-PPP is validated in both static and kinematic cases. Results show that the positioning errors of Smart-PPP solutions can converge to below 1.0 m within a few minutes in static mode and the converged solutions can achieve an accuracy of about 0.2 m of root mean square (RMS) both for the east, north and up components. For the kinematic test, the RMS values of Smart-PPP positioning errors are 0.65, 0.54 and 1.09 m in the east, north and up components, respectively. Static and kinematic tests both show that the Smart-PPP solutions outperform the internal results provided by the experimental smart devices.
The Additive Effect of CBT Elements on the Video Game ‘Mindlight’ in Decreasing Anxiety Symptoms of Children with Autism Spectrum Disorder
Authors: Wijnhoven Lieke A. M. W. , Engels Rutger C. M. E. , Onghena Patrick , Otten Roy , Creemers Daan H. M. 
Published: March 2021

AbstractThe aim of the present study was to examine the additive effect of elements of cognitive behavioral therapy (CBT) on the video game Mindlight in decreasing anxiety of children with an autism spectrum disorder (ASD). A non-concurrent multiple baseline design with 8 children with ASD in the age of 8–12 was used. CBT did not have the hypothesized additive effect on Mindlight in decreasing anxiety of children with ASD. Instead, multiple participants already experienced a decrease in anxiety during the Mindlight sessions. Yet, several participants did experience a stabilization in anxiety at a low level during the CBT sessions. For now, it can be concluded that CBT does not have an additive effect on Mindlight.
The Effect of Dissolved Nitrogen on the Fatigue Behavior of Ti-6Al-4V
Authors: Collins C. R. , Dear F. F. , Rugg D. , Dye D. 
Published: March 2021

Abstract
The effect of nitrogen additions on fatigue behavior has been examined in near-equiaxed, rolled Ti-6Al-4V bar. This is the first-time nitrogen content that has been systematically explored with respect to monotonic and cyclic properties in a Ti-6Al-4V alloy base composition. Nitrogen additions were found to increase the

$$\beta $$

β

-transus temperature and strength, but they decreased ductility, even in microstructures where some

$$\beta $$

β

phase remained. This carried across into both the low- and high cycle fatigue behavior; even small contents of 240 and 560 ppmwN caused reductions in both low cycle fatigue life and high cycle fatigue strength. In samples containing 240 and 560 ppmwN, a conventional striated fractographic appearance was observed, but a dramatic change to a macroscopically brittle fracture surface was observed at 1800 and 3600 ppmwN, but still with substantial evidence of plasticity at the microscale. Therefore, neither microstructure or fractographic examination, nor EDX-based compositional analysis in the electron microscope are necessarily a reliable indicator of an absence of deleterious nitrogen contamination. This is significant for the investigation of potentially nitrogen-contaminated surface-initiated cracks, either due to service or processing exposures.
Effects of Liquid Digestate Treatment on Sustainable Microalgae Biomass Production
Authors: Kisielewska Marta , Dębowski Marcin , Zieliński Marcin , Kazimierowicz Joanna , Quattrocelli Piera , Bordiean Anna 
Published: March 2021

AbstractThe aim of the study was to investigate the potential of microalgal cultivation on anaerobic liquid digestate as a growth medium. The two methods of liquid digestate treatment including centrifugation and distillation and the two algal strains (Chlorella vulgaris and Arthrospira platensis) were compared. Additionally, the volume of the liquid digestate used to prepare the culture medium constituted from 10 to 50% of the medium volume. The study demonstrated that the highest C. vulgaris and A. platensis biomass productions of 2490 mg TS/L and 2990 mg/L, respectively, were obtained by adding 50% of distilled digestate to a growth medium. Regarding centrifuged liquid digestate, only 10% dilution was required to obtain the maximum final biomass concentration. A. platensis removed 81.1% and 66.4% of the total nitrogen from medium prepared on distilled and centrifuged digestate, respectively, while C. vulgaris ensured 64.1% and 47.1% of removal, respectively. The phosphorus removal from both culture media was higher than 94.2% with A. platensis, while it was 70.4% from distilled and 87.4% from centrifuged media with C. vulgaris. The study confirmed a great potential of microalgal biomass production on anaerobic liquid digestate with a high treatment efficiency of digestate.
Sauropterygian remains from the Middle Triassic of Villány, Hungary—new information on the aquatic reptile fauna of Tisza Megaunit (Triassic southern Eurasian shelf region)
Authors: Segesdi Martin , Ősi Attila 
Published: March 2021

AbstractSauropterygia was a diverse clade of secondary aquatic reptiles, which represented one of the most important vertebrate groups in the shallow marine communities during the Triassic. However, despite the long history of collection and examination of sauropterygian remains, previous studies have indicated that the fossil record of this group is incomplete, making the understanding of their palaeobiogeographic relations difficult. Here we describe new sauropterygian remains from the Middle Triassic (Ladinian) Templomhegy Dolomite Member (Villány, southern Hungary), which were unearthed during systematic fieldwork of previous years. Among several non-diagnostic sauropterygian remains, this material contains isolated bones belonging to Nothosaurus sp., Simosauridae indet. and a small-sized nothosaurid. The known faunal composition from Villány is similar to what was described from the Middle Triassic of the Germanic Basin and Bihor Mountains (northwestern Romania). Besides isolated elements, a probably associated skeleton of a small-sized eosauropterygian specimen of unknown affinities is also reported here. This locality widens our knowledge on Triassic sauropterygian distribution and provides new information about the previously not well-known Middle Triassic vertebrate fauna of the one-time southern Eurasian shelf region.