bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimising of vacuum distillation units using surrogate models
Authors: H’ng S X , Ng L Y , Ng D K S , Andiappan V 
Published: November 2021

Abstract
Crude oil blending is an important step for the operation of crude distillation systems in the refinery to improve the yield and profitability of the products. The product’s yield and quality are strongly dependent on the properties of the crude oil. However, the products of crude distillation units, especially the vacuum distillation unit (VDU) need to satisfy the yield and quality requirements of the downstream process units in the refinery. Otherwise, the performance of downstream processes will be affected, and loss of profitability in the refinery. Hence, it is important to optimise the performance of the VDU to ensure the optimum operation of VDU. This work covers the process simulation of VDU, surrogate modelling and mathematical optimisation model. The objective of the developed optimisation model is to determine an optimal for maximum high vacuum gas oil (HVGO) yield and minimum total annualised cost (TAC) respectively. To do this, crude oil blending ratio, column temperature, column pressure, stripping steam flowrate, pump-around flowrate in the VDU are optimised. Based on the optimised result, the heavy-light crude blend achieves higher HVGO yield and lower TAC as compared to the heavy-medium crude blend and heavy-medium-light crude blend. The optimised results can provide insight into the optimal process conditions of VDU for the refiners. With this insight, effective operating strategies can be developed to overcome the limitations present in real VDU operations.
Utilization of supercritical carbon dioxide (SC-CO2) in lipids extraction from sewage sludge cake: A preliminary study
Authors: Khalil N A , Hamid H A , Fizal A N S , Zulkifli M , Hossain M S , Yahaya A N A 
Published: November 2021

Abstract
Sewage sludge containing a large number of lipids that can be recovered and utilised as a promising raw material in the production of biodiesel. Studies have been conducted to extract lipids from sludge using conventional solvent methods. However, all these conventional methods have some limitations such as extensive product separation and long extraction time (between 4 to 8 hours), which lead to high energy consumption. Supercritical carbon dioxide extraction (SFE) which utilises carbon dioxide (CO2) gas at its critical condition as solvent has been studied extensively in various fields for oil extraction especially for plant and vegetative. This is due to the shorter extraction time and the lipids can be easily separated from the extraction system. The present research has undertaken a comparison study of supercritical carbon dioxide (SC-CO2) utilisation in the extraction of lipids from sewage sludge against conventional soxhlet extraction of methanol and ethanol as solvent. The extraction of lipids from sewage sludge utilising SC-CO2 extraction was successfully being conducted with lipids yield of 0.69 % within 0.5 hours at the operating temperature of 50 °C and pressure of 20 MPa. The lipids were easily separated subsequently from the SFE system when CO2 is being released in gas form through the outlet valve during lipids collection. Whilst soxhlet extraction using methanol and ethanol as solvent (sludge: solvent ratio of 1:10) managed to extract 1.95 % and 2.81 % within 4 hours of extraction time at 60 °C, with the additional time needed to separate the lipids from solvent by evaporation.
Fundamental study of colloidal stability and dispersion of novel nanosized conductive polyaniline (PANI)/prevulcanised latex (PVL) film for antimicrobial applications
Authors: Banjar M F , Suphi H D , Sarizan M I , Yahaya A N A , Khalil N A , Singh M , Zulkifli M 
Published: November 2021

Abstract
A smart material possessed enhanced conductivity integrated in prevulcanized latex (PVL) film produced throughout this work. Also recognizing the synthesis route of PANI was vast and vary, choosing suitable method was great importance corresponding to the aim of study. PANI was prepared through chemical oxidative polymerization of aniline carried out in aqueous solution which aniline dissolved in strong acidic solution (1 M HCl) with the presence of Ammonium Persulphate (APS) as the oxidizing agent and Sodium Dodecyl Sulphate (SDS) as surfactant. However, PANI was readily in acidic condition while PVL in basic and consequently causes a state of immiscibility upon mixing. Hence, PANI formed then mixed with 0.1 – 0.5 % KOH via homogenizer to increase the pH and maintain the homogeneity as well as dispersion to be combined with PVL. Various studies on PANI synthesis and incorporation with latex had been reported but very limited in focusing the colloidal and dispersion stability of the mixture. Zeta potential measurements revealed an effective dispersion and the colloidal stability as the pH of PANI increases. Analysis of mechanical performance using Universal testing Machine revealed that addition of PANI improves greatly in novel film tensile strength and Young’s Modulus by 109 % and 230 %, respectively.
Influence of anode temperature on ignition performance of the IRIT4-2D iodine-fueled radio frequency ion thruster
Authors: ZHANG Xinghua , ZHANG Zhenhua , JIA Shaoxia , JIN Ting , YANG Jinghua , LI Long , LIU Fangfang , CAI Yong , CAI Jian 
Published: November 2021

Abstract
This paper reports the ignition performance of the iodine-fueled radio frequency (RF) ion thruster (IRIT) at different anode temperatures (

T

a0

). The experimental results show that the anode temperature plays important role on the ignition process of the IRIT. There were two characteristic temperatures related to the anode: the minimum ignition temperature (

T

i0

) and the stable ignition temperature (

T

is

), which were much lower than the pipeline temperature and the storage tank temperature. At

T

a0

<

T

i0

,

it failed to discharge. When

T

i0

≤

T

a0

<

T

is

,

it was ignited with dramatical oscillations. At

T

a0

≥

T

is

,

the discharge was stable in a large anode temperature range. The analysis showed that the different discharge phenomena at different anode temperatures were attributed to the change of iodine flow rate during the process of the iodine deposition-clogging and sublimation-clearing inside the thruster. The research helps improve the preheating design of the iodine-fueled electric thruster.
Thermoelectric efficiency of anisotropic materials with an application in layered systems
Authors: Shi Wencong , Woods Lilia M 
Published: November 2021

Abstract
Thermoelectric (TE) transport in anisotropic materials is investigated based on most general thermodynamical concepts. Currents and power conversion efficiency are studied in SnSe and SnS in different directions. The design of composites whose TE performance along different principles directions is the same is proposed. Although such features do not occur naturally, such man-made anisotropic materials can be constructed using bilayers achieving much broadened working conditions of TE conversion devices. Intricate relationships between the anisotropy and the direction of the electric and heat currents are revealed, which further help us understand how transport occurs in such composites.
Quality improvement and reconciliation process for automated dispensing cabinet medication overrides
Authors: Rhodes James A M , Bondi Deborah S , Celmins Laura , Hope Charlene , Knoebel Randall W 
Published: November 2021

Abstract

Purpose
To describe a pharmacist-led reconciliation process for automated dispensing cabinet (ADC) medication override setting maintenance at an academic medical center.

Summary
ADC override management requires alignment of people, processes, and technology. This evaluation describes system-wide improvements to enhance institutional medication override policy compliance by establishing a formalized evaluation and defined roles to streamline ADC dispense setting management. A pharmacist-led quality improvement initiative revised the institutional medication override list to improve medication dispensing practices across an academic medical center campus with a pediatric hospital and 2 adult hospitals. This initiative included removal of patient care unit designations from the medication override list, revision of institutional override policy, creation of an online submission form, and selection of ADC override metrics for surveillance. A conceptual framework guided decisions for unique dosage forms and interdisciplinary engagement. Employing this framework revised workflows for stakeholders in the medication-use process through clinical pharmacist evaluation, existing shared governance structure communication, and pharmacy automation support.
The revised policy increased the number of medications available for override from 80 to 106 (33% increase) and unique dosage forms from 166 to 191 (15% increase). The total number of medication dispense settings was reduced from 5,600 to 541 (90% decrease). The proportion of override dispenses compliant with policy increased from 59% to 98% (P &lt; 0.001). Median monthly ADC overrides remained unchanged following policy revision (P = 0.995). ADC override rate reduction was observed across the institution, with the rate decreasing from 1.4% to 1.2% (P &lt; 0.001). Similar ADC override rate reductions were observed for adult, pediatric, and emergency department ADCs.

Conclusion
This initiative highlights pharmacists’ role in leading institutional policy changes that influence the medication-use process through ADC dispensing practices. A pharmacist-led reconciliation process that removed practice area designations from our medication override policy streamlined ADC setting maintenance, increased the compliance rate of ADC override transactions, and provided a formalized process for future evaluation of medication overrides.
Impact of Variability in Job Coding on Reliability in Exposure Estimates Obtained via a Job-Exposure Matrix
Authors: Rémen Thomas , Richardson Lesley , Siemiatycki Jack , Lavoué Jérôme 
Published: November 2021

Abstract

Objectives
The use of a job-exposure matrix (JEM) to assess exposure to potential health hazards in occupational epidemiological studies requires coding each participant’s job history to a standard occupation and/or industry classification system recognized by the JEM. The objectives of this study were to assess the impact of inter-coder variability in job coding on reliability in exposure estimates derived from linking the job codes to the Canadian job-exposure matrix (CANJEM) and to identify influent parameters.

Method
Two trained coders independently coded 1000 jobs sampled from a population-based case–control study to the ISCO-1968 occupation classification at the five-digit resolution level, of which 859 could be linked to CANJEM using both assigned codes. Each of the two sets of codes was separately linked to CANJEM and thereby generated, for each of the 258 occupational agents available in CANJEM, two exposure estimates: exposure status (yes/no) and intensity of exposure (low, medium, and high) for exposed jobs only. Then, inter-rater reliability (IRR) was computed (i) after stratifying agents in 4 classes depending, for each, on the proportion of occupation codes in CANJEM defined as ‘exposed’ and (ii) for two additional scenarios restricted to jobs coded differently: the first one using experts’ codes, the other one using codes randomly selected. IRR was computed using Cohen’s kappa, PABAK and Gwet’s AC1 index for exposure status, and weighted kappa and Gwet’s AC2 for exposure intensity.

Results
Across all agents and based on all jobs, median (Q1, Q3; Nagents) values were 0.68 (0.59, 0.75; 220) for kappa, 0.99 (0.95, 1.00; 258) for PABAK, and 0.99 (0.97, 1.00; 258) for AC1. For the additional scenarios, median kappa was 0.28 (0.00, 0.45; 209) and −0.01 (−0.02, 00; 233) restricted to jobs coded differently using experts’ and random codes, respectively. A similar decreasing pattern was observed for PABAK and AC1 albeit with higher absolute values. Median kappa remained stable across exposure prevalence classes but was more variable for low prevalent agents. PABAK and AC1 decreased with increasing prevalence. Considering exposure intensity and all exposed jobs, median values were 0.79 (0.68, 0.91; 96) for weighted kappa, and 0.95 (0.89, 0.99; 102) for AC2. For the additional scenarios, median kappa was, respectively, 0.28 (−0.04, 0.42) and −0.05 (−0.18, 0.09) restricted to jobs coded differently using experts’ and random codes, with a similar though attenuated pattern for AC2.

Conclusion
Despite reassuring overall reliability results, our study clearly demonstrated the loss of information associated with jobs coded differently. Especially, in cases of low exposure prevalence, efforts should be made to reliably code potentially exposed jobs.
Nesfatin-1 inhibits free fatty acid (FFA)-induced endothelial inflammation via Gfi1/NF-κB signaling
Authors: Meng Qingtao , Lu Qin , Zhang Zhipeng , Liu Jiyi , Lou Yu , Wang Yuwei , Liu Jihong 
Published: November 2021

ABSTRACT
Nesfatin-1 is a neuropeptide produced in the hypothalamus. It is known that Nesfatin-1 is involved in food uptake, fat storage, and other metabolic regulation. We hypothesized that Nesfatin-1 may play a role in cardiovascular tissue. Free fatty acids (FFAs) are known to be the risk factor for cardiovascular diseases. FFA-mediated endothelial dysfunction is the critical mechanism of many cardiovascular disorders. The present study explores the protective effects of Nesfatin-1 on FFA-induced endothelial inflammation and the underlying mechanism. We found that significantly increased lactate dehydrogenase release and production of inflammatory factors were observed in FFA-treated human aortic endothelial cells (HAECs), accompanied by the enhanced attachment of U937 monocytes to HAECs and upregulated cell adhesion molecule vascular cell adhesion molecule-1, which were dramatically reversed by the treatment with Nesfatin-1. In addition, the promoted level of nuclear regulator NF-κB p65 and transcriptional function of NF-κB in FFA-treated HAECs were greatly suppressed by HAECs. Growth Factor Independent 1 Transcriptional Repressor 1 (Gfi1), an important negative regulator of NF-κB activity, was significantly downregulated in HAECs by FFAs and was upregulated by Nesfatin-1. Lastly, the inhibitory effects of Nesfatin-1 against FFA-induced NF-κB activation and adhesion of U937 monocytes to HAECs were abolished by the knockdown of Gfi1. In conclusion, our data reveal that Nesfatin-1 inhibited FFA-induced endothelial inflammation mediated by the Gfi1/NF-κB signaling pathway.
Structural equation modeling reveals determinants of fitness in a cooperatively breeding bird
Authors: Busana Michela , Weissing Franz J , Hammers Martijn , Bakker Joke , Dugdale Hannah L , Raj Pant Sara , Richardson David S , Burke Terrence A , Komdeur Jan 
Published: November 2021

Abstract
Even in well-studied organisms, it is often challenging to uncover the social and environmental determinants of fitness. Typically, fitness is determined by a variety of factors that act in concert, thus forming complex networks of causal relationships. Moreover, even strong correlations between social and environmental conditions and fitness components may not be indicative of direct causal links, as the measured variables may be driven by unmeasured (or unmeasurable) causal factors. Standard statistical approaches, like multiple regression analyses, are not suited for disentangling such complex causal relationships. Here, we apply structural equation modeling (SEM), a technique that is specifically designed to reveal causal relationships between variables, and which also allows to include hypothetical causal factors. Therefore, SEM seems ideally suited for comparing alternative hypotheses on how fitness differences arise from differences in social and environmental factors. We apply SEM to a rich data set collected in a long-term study on the Seychelles warbler (Acrocephalus sechellensis), a bird species with facultatively cooperative breeding and a high rate of extra-group paternity. Our analysis reveals that the presence of helpers has a positive effect on the reproductive output of both female and male breeders. In contrast, per capita food availability does not affect reproductive output. Our analysis does not confirm earlier suggestions on other species that the presence of helpers has a negative effect on the reproductive output of male breeders. As such, both female and male breeders should tolerate helpers in their territories, irrespective of food availability.
It’s up to you: The need for self-directed learning for social work students on placement during COVID-19
Authors: Zuchowski Ines , Cleak Helen , Croaker Sandra , Davey Jo-Bentley 
Published: November 2021

Summary
COVID-19 in 2020 took social work programmes by surprise and for many students an e-placement was offered as the only alternative learning opportunity to complete their placement that year. In this article, we report on a mixed method study with data collected via an online survey with quantitative and qualitative questions exploring students’ experiences in e-placements. Eighty-two students who had undertaken an e-placement responded to the survey that was sent to 1,500 social work students enrolled in twenty-one Australian universities. The results summarise demographic data about the students and a description of the e-placements used, as well as qualitative themes about the students’ experiences and recommendations about e-placements. Four themes were prominent in the qualitative data: ‘opportunities for flexible learning but can be challenging’, ‘learning new skills but missing out on others’, ‘drive your own learning’ and ‘the need for structure, support and connection’. Most students reported that they learnt a range of social work skills, but this required them to take initiative to ensure that learning occurred. The implication for social work education underscores the importance of future proofing social work field education through examining the learning and providing proactive support and clear structures for alternatives to traditional placements.
Oral contraceptives and risk of breast cancer and ovarian cancer in women with a BRCA1 or BRCA2 mutation: a meta-analysis of observational studies
Authors: Park Junli , Huang Dan , Chang Yoon Jung , Lim Myong Cheol , Myung Seung-Kwon 
Published: November 2021

Abstract
It remains inconclusive whether the use of oral contraceptives (OCs) alters the risks of breast or ovarian cancer in women with a breast cancer susceptibility gene 1 (BRCA1) or breast cancer susceptibility gene 2 (BRCA2) mutation. We investigated the association between OC use and the risks of breast or ovarian cancer in this group by using a meta-analysis. PubMed and EMBASE were searched using keywords until February 2021 to identify relevant studies that evaluated the association between OC ever use and the risks of breast or ovarian cancer in women with a BRCA1 or BRCA2 mutation. Twelve studies for breast cancer and eight studies for ovarian cancer were identified. In the random-effects meta-analysis, the ever use of OCs was significantly associated with an increased risk of breast cancer [odds ratio (OR), relative risk (RR) or hazard ratio (HR) = 1.24; 95% confidence interval (CI) 1.08–1.41] and a decreased risk of ovarian cancer (OR/RR/HR = 0.53, 95% CI 0.41–0.67). Consistent findings were observed when BRCA1 and BRCA2 mutation carriers were analyzed separately. The increased risk of breast cancer was observed only in the long-term (&gt;5 years) users of OCs, while the decreased risk of ovarian cancer was observed regardless of the duration of OC use. The current study suggests that the ever use of OCs in BRCA mutation carriers is significantly associated with an increased risk of breast cancer and a decreased risk of ovarian cancer. Therefore, the use of OCs as chemoprevention of ovarian cancer should be cautious in BRCA mutation carriers.
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern
Authors: Lien Chia-En , Kuo Tsun-Yung , Lin Yi-Jiun , Lian Wei-Cheng , Lin Meei-Yun , Liu Luke Tzu-Chi , Cheng Jinyi , Chou Yu-Chi , Chen Charles 
Published: November 2021

Abstract

Background
Variants of concern (VoCs) have the potential to diminish the neutralizing capacity of antibodies elicited by vaccines. MVC-COV1901 is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine consisting of recombinant prefusion stabilized spike protein S-2P adjuvanted with CpG 1018 and aluminum hydroxide. We explored the effectiveness of MVC-COV1901 against the VoCs.

Methods
Serum samples were taken from rats and phase 1 clinical trial human subjects immunized with a low, medium, or high dose of MVC-COV1901. The neutralizing titers of serum antibodies were assayed with pseudoviruses coated with the SARS-CoV-2 spike protein of the wild-type (WT), D614G, Alpha, or Beta variants.

Results
Rats vaccinated twice with vaccine containing high doses of antigen retained high levels of neutralization activity against the Beta variant, albeit with a slight reduction compared to WT. After the third dose, neutralizing titers against the Beta variant were noticeably enhanced regardless of the amount of antigen used for immunization. In humans, vaccinated phase 1 subjects still showed appreciable neutralization abilities against the D614G, Alpha, and Beta variants, although neutralizing titers were significantly reduced against the Beta variant.

Conclusions
Two doses of MVC-COV1901 were able to elicit neutralizing antibodies against SARS-CoV-2 variants with an overall tendency of inducing higher immune response at a higher dose level. The neutralizing titers to the Beta variant in rats and humans were lower than those for WT and the Alpha variant. An additional third dose in rats was able to partially compensate for the reduction in neutralization against the Beta variant. We have demonstrated that immunization with MVC-COV1901 was effective against VoCs.