bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Alzheimer’s Disease and Related Dementias Pathology Among African American and Hispanic Women: A Qualitative Literature Review of Biomarker Studies
Authors: Royse Sarah K. , Cohen Ann D. , Snitz Beth E. , Rosano Caterina 
Published: July 2021

IntroductionThe population of older adults with Alzheimer’s disease and Related Dementias (ADRD) is growing larger and more diverse. Prevalence of ADRD is higher in African American (AA) and Hispanic populations relative to non-Hispanic whites (nHW), with larger differences for women compared to men of the same race. Given the public health importance of this issue, we sought to determine if AA and Hispanic women exhibit worse ADRD pathology compared to men of the same race and nHW women. We hypothesized that such differences may explain the discrepancy in ADRD prevalence.MethodsWe evaluated 932 articles that measured at least one of the following biomarkers of ADRD pathology in vivo and/or post-mortem: beta-amyloid (Aß), tau, neurodegeneration, and cerebral small vessel disease (cSVD). Criteria for inclusion were: (1) mean age of participants &gt;65 years; (2) inclusion of nHW participants and either AA or Hispanics or both; (3) direct comparison of ADRD pathology between racial groups.ResultsWe included 26 articles (Aß = 9, tau = 6, neurodegeneration = 16, cSVD = 18), with seven including sex-by-race comparisons. Studies differed by sampling source (e.g., clinic or population), multivariable analytical approach (e.g., adjusted for risk factors for AD), and cognitive status of participants. Aß burden did not differ by race or sex. Tau differed by race (AA &lt; nHW), and by sex (women &gt; men). Both severity of neurodegeneration and cSVD differed by race (AA &gt; nHW; Hispanics &lt; nHW) and sex (women &lt; men). Among the studies that tested sex-by-race interactions, results were not significant.ConclusionFew studies have examined the burden of ADRD pathology by both race and sex. The higher prevalence of ADRD in women compared to men of the same race may be due to both higher tau load and more vulnerability to cognitive decline in the presence of similar Aß and cSVD burden. AA women may also exhibit more neurodegeneration and cSVD relative to nHW populations. Studies suggest that between-group differences in ADRD pathology are complex, but they are too sparse to completely explain why minority women have the highest ADRD prevalence. Future work should recruit diverse cohorts, compare ADRD biomarkers by both race and sex, and collect relevant risk factor and cognitive data.
Cancer Stemness Associated With Prognosis and the Efficacy of Immunotherapy in Adrenocortical Carcinoma
Authors: Shi Xiaoxi , Liu Yuanlin , Cheng Shuai , Hu Haidi , Zhang Jian , Wei Minjie , Zhao Lin , Xin Shijie 
Published: July 2021

BackgroundCancer stem cells (CSCs) have been proven to influence drug resistance, recurrence, and metastasis in tumors. Our study aimed to identify stemness-related prognostic biomarkers for new therapeutic strategies in adrenocortical carcinoma.MethodsRNA-seq data and clinical characteristics were downloaded from The Cancer Genome Atlas (TCGA). The stemness indexes, mDNAsi and mRNAsi, were calculated to classify all samples into low-score and high-score groups. Two algorithms, based on the R language, ESTIMATE and single-sample Gene Set Enrichment Analysis (ssGSEA) were used to assess the immune cell infiltration states of adrenocortical carcinoma patients. Weighted Gene Co-expression Network Analysis (WGCNA) was used to find genes that were related to the stemness of cancer. By bioinformatics methods, the correlations between biomarkers capable of predicting immune checkpoint inhibitors (ICIs) responses and stemness of cancer were explored.ResultsHigh-mRNAsi predicted shorter overall survival (OS) and a higher metastatic trend in adrenocortical carcinoma (ACC) patients. Compared with the low-mRNAsi group, the high-mRNAsi group had a lower ImmuneScore and StromalScroe. Twenty-two stemness-related prognostic genes were obtained by WGCNA, which focused on the function of the cell cycle and cell mitosis. Immune cell infiltration, especially CD8+T cell, increased in the low-mRNAsi group compared with the high-mRNAsi group. Lower expression of PD-L1, CTLA-4, and TIGHT was evaluated in the high-mRNAsi group.ConclusionsACC patients with high-mRNAsi have poor prognosis and less immune cell infiltration. Combined with the finding of lower expression of CTLA-4, TIGHT, and PD-L1 in the high-mRNAsi group, we came to the conclusion that stemness index is a potential biomarker to predict the effectiveness of ICIs.
Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial–Mesenchymal Transition in Hypoxic NSCLC Cells via the HIF-1α/PFKP Axis
Authors: Zhang Linling , Ke Jingjing , Min Shengping , Wu Nan , Liu Fei , Qu Zhen , Li Wei , Wang Hongtao , Qian Zhongqing , Wang Xiaojing 
Published: July 2021

BackgroundTumor cells initiate hypoxia-induced mechanisms to fuel cell proliferation, invasion, and metastasis, largely mediated by low O2-responsive Hypoxia-Inducible Factor 1 Alpha (HIF-1α). Therefore, hyperbaric oxygen therapy (HBO) is now being studied in cancer patients, but its impact upon non-small-cell lung cancer (NSCLC) cell metabolism remains uncharacterized.MethodsWe employed the NSCLC cell lines A549 and H1299 for in vitro studies. Glucose uptake, pyruvate, lactate, and adenosine triphosphate (ATP) assays were used to assess aerobic glycolysis (Warburg effect). A quantitative glycolytic flux model was used to analyze the flux contributions of HIF-1α-induced glucose metabolism genes. We used a Lewis lung carcinoma (LLC) murine model to measure lung tumorigenesis in C57BL/6J mice.ResultsHBO suppressed hypoxia-induced HIF-1α expression and downstream HIF-1α signaling in NSCLC cells. One HIF-1α-induced glucose metabolism gene—Phosphofructokinase, Platelet (PFKP)—most profoundly enhanced glycolytic flux under both low- and high-glucose conditions. HBO suppressed hypoxia-induced PFKP transactivation and gene expression via HIF-1α downregulation. HBO’s suppression of the Warburg effect, suppression of hyperproliferation, and suppression of epithelial-to-mesenchymal transition (EMT) in hypoxic NSCLC cell lines is mediated by the HIF-1α/PFKP axis. In vivo, HBO therapy inhibited murine LLC lung tumor growth in a Pfkp-dependent manner.ConclusionsHBO’s repression of the Warburg effect, repression of hyperproliferation, and repression of EMT in hypoxic NSCLC cells is dependent upon HIF-1α downregulation. HIF-1α’s target gene PFKP functions as a central mediator of HBO’s effects in hypoxic NSCLC cells and may represent a metabolic vulnerability in NSCLC tumors.
Neoadjuvant Immunotherapy of Oral Squamous Cell Carcinoma: Case Report and Assessment of Histological Response
Authors: Olmos Manuel , Glajzer Jacek , Büntemeyer Tjark-Ole , Frohwitter Gesche , Ries Jutta , Eckstein Markus , Hecht Markus , Lutz Rainer , Kesting Marco Rainer , Weber Manuel 
Published: July 2021

BackgroundThe treatment of oral cancer remains challenging due to its infiltrative nature and a high tendency for tumour relapse leading to an overall poor prognosis. In the case of early recurrence, the patient’s prognosis deteriorates dramatically, with survival rate dropping to below 30%. Minimal improvements in survival trends in recurrent and advanced stage tumours have been reported in recent decades. Neoadjuvant immunotherapy may represent a new therapeutic approach changing the standard of care in advanced oral cancer therapy.Case PresentationWe describe the case of a woman in her late 30’s who presented in mid-2019 with oral squamous cell carcinoma (OSCC) localized to the floor of the mouth. After initial R0 resection, selective neck dissection, and adjuvant brachytherapy, an early recurrence of OSCC located between the hyoid bone and the mandible was diagnosed at the end of 2019. An off-label treatment regimen was performed with neoadjuvant use of Pembrolizumab 19 days prior to salvage surgery. Radiological and histological assessment of T-cell and programmed cell death protein 1 ligand 1 (PD-L1) expression was performed before and after checkpoint inhibitor application. Neoadjuvant immunotherapy resulted in increased T-cell infiltration and PD-L1 expression, as well as a significant tumour necrosis rate. One cycle of Pembrolizumab led to significant regressive tumour changes with increases in immune infiltration, sclerosis, and necrosis of 75% of the tumour mass with only 25% vital tumour cells remaining. By June 2020, the patient remained without recurrence.ConclusionsThe case presented outlines the potential effects of neoadjuvant immunotherapy in recurrent or advanced OSCC prior to definitive surgical tumour treatment. The benefit of additional adjuvant treatment after histologic response will be discussed. The case is also analysed considering ongoing clinical trials of neoadjuvant immunotherapy for head and neck malignancies.
Population-Based Cohort of Children With Parapneumonic Effusion and Empyema Managed With Low Rates of Pleural Drainage
Authors: Moral Luis , Toral Teresa , Clavijo Agustín , Caballero María , Canals Francisco , Forniés María José , Moral Jorge , Revert Raquel , Lucas Raquel , Huertas Ana María , González María Cristina , García-Avilés Belén , Belda Mónica , Marco Nuria 
Published: July 2021

Introduction: The most appropriate treatment for parapneumonic effusion (PPE), including empyema, is controversial. We analyzed the experience of our center and the hospitals in its reference area after adopting a more conservative approach that reduced the use of chest tube pleural drainage (CTPD).Methods: Review of the clinical documentation of all PPE patients in nine hospitals from 2010 to 2018.Results: A total of 318 episodes of PPE were reviewed; 157 had a thickness of &lt;10 mm. The remaining 161 were 10 mm or thicker and were subdivided into three increasing sizes: PE+1, PE+2, and PE+3. There was a strong relationship between the size of the effusion and complicated effusion/empyema, defined by its appearance on imaging studies or by the physical or bacteriological characteristics of the pleural fluid. The size of effusion was also strongly related to the duration of fever and intravenous treatment and was the best independent predictor of the length of hospital stay (LHS) (p &lt; 0.001). CTPD was placed in 2.9% of PE+1 patients, 19.3% of PE+2, and 63.9% of PE+3 (p &lt; 0.001). The referral of patients with PE+1 decreased over time (p = 0.033), as did the use of CTPD in the combined PE+1/PE+2 group (p = 0.018), without affecting LHS (p = 0.814). There were no changes in the use of CTPD in the PE+3 group (p = 0.721).Conclusions: The size of the PPE is strongly correlated with its severity and with LHS. Most patients can be treated with antibiotics alone.
Effects of Tranexamic Acid on Hemorrhage Control and Deep Venous Thrombosis Rate After Total Knee Arthroplasty: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: Ling Tao , Zhao Zhihu , Xu Wenwen , Ge Weihong , Huang Lingli 
Published: July 2021

Background: Total knee arthroplasty (TKA) surgery has a lot of complications, especially hemorrhage, which can be controlled via tranexamic acid (TXA). The guidelines endorse the integration of TXA interventions in the management of TKA-induced complications. However, uncertainty surrounds the effects of different TXA therapies. This frequentist model network meta-analysis (NMA) aims to compare hemorrhage control and deep venous thrombosis (DVT) rate of different TXA therapies in TKA.Methods: Articles were searched with the PubMed, Embase, Cochrane Library, and Web of Science from 1966 to October 2020. Randomized controlled trials (RCTs) comparing different TXA therapies, or with placebo in patients with TKA were included. Two investigators independently conducted article retrievals and data collection. The outcome was total blood loss and DVT rate. Effect size measures were mean differences (MDs), or odds ratios (ORs) with 95% confidence intervals (CIs). We conducted a random-effects NMA using a frequentist approach to estimate relative effects for all comparisons and rank treatments according to the mean rank and surface under the cumulative ranking curve values. All analyses were performed in Stata software or R software. The study protocol was registered with PROSPERO, number CRD42020202404.Results: We identified 1 754 citations and included 81 studies with data for 9 987 patients with TKA. Overall, all TXA therapies were superior to placebo for total blood loss in TKA. Of all TXA therapies, M therapy (IV/IV infusion + oral TXA &gt; 3g) was most effective for total blood loss (MD=−688.48, −1084.04–−328.93), followed by F therapy (IV TXA ≥ 15 mg/kg or 1 g three times). TXA therapies in this study are not associated with the increase of DVT risk.Conclusions: TXA therapies in this study are effective and safe for the treatment of TKA-induced complications. M therapy (IV/IV infusion + oral TXA &gt; 3 g) may be the most effective TXA therapy for hemorrhage control. TXA therapies in this study do not increase DVT risk. Considering hemorrhage control and DVT rate simultaneously, F therapy (IV TXA ≥ 15 mg/kg or 1 g three times) may be suggested to apply for TKA, and this study may provide a crucial clue to future TXA use.
The Relationship Between Crime-Related Television Viewing and Perceptions of the Death Penalty: Results of a Large Cross-Sectional Survey Study
Authors: Till Benedikt , Arendt Florian , Niederkrotenthaler Thomas 
Published: July 2021

Background:According to cultivation theory, distorted representations of social reality on television can lead to distorted perceptions of reality among viewers. For example, the death penalty has been abolished in most Western countries a long time ago, but is often portrayed or mentioned in US crime shows, which are very popular outside the United States. Previous research suggests that the amount of television viewing can be associated with erroneous perceptions of the use of the death penalty—even when the death penalty is not used in the respective country. Unfortunately, available evidence on this association is inconclusive.Methods:In a cross-sectional web-based survey, we used quota-based sampling techniques to recruit 1,002 individuals representative of the Austrian population in terms of gender, age, education, and region of residence. We asked about their weekly amount of television viewing and use of US crime dramas and measured their beliefs on the use of the death penalty in Austria.Results:Although television viewing in general was not associated with erroneous perceptions of the death penalty (i.e., no overall across-the-board cultivation effect), data analysis provided supporting evidence for the idea of a genre-specific cultivation effect: The more US crime shows participants watched, the more likely they were to mistakenly believe that the death penalty is used in Austria. This association held true even after controlling for the gender, age, and education of participants.Conclusion:The finding that watching US crime shows, which are based on social reality in the United States, is associated with Austrian viewers' confusion with regards to perceptions of the death penalty is consistent with the genre-specific cultivation hypothesis. Some viewers may be guided more by mediated reality than by actual social reality.
Cortical Correlates of Impulsive Aggressive Behavior in Pediatric Bipolar Disorder
Authors: Simonetti Alessio , Kurian Sherin , Saxena Johanna , Verrico Christopher D. , Restaino Antonio , Di Nicola Marco , Soares Jair C. , Sani Gabriele , Saxena Kirti 
Published: July 2021

Background: Impulsive aggression represents a frequent characteristic of pediatric bipolar disorder (PBD). Cortical alterations associated with impulsive aggression and its multiple facets have not been investigated yet in youth with bipolar disorder.Aim: To investigate the relationship between cortical thickness and facets of impulsive aggression in youth with PBD.Materials and Methods: Twenty-three youth with PBD and 23 healthy controls (HC) were administered the aggression questionnaire (AQ) and underwent 3T magnetic resonance imaging scan. Cortical thickness was assessed with FreeSurfer. Canonical correlation analyses were used to investigate the relationship between AQ total and subscale scores and cortical thickness in youth with PBD.Results: Youth with PBD had increased scores in the subscales of AQ-anger and AQ-hostility and cortical thinning in in areas belonging to the affective network (AN), frontoparietal network (FPN) and cingulo-opercular network (CON), i.e., right rostral anterior cingulate, right caudal anterior cingulate, right lateral orbitofrontal, right medial orbitofrontal, left and right inferior parietal, left posterior cingulate, left and right supramarginal left lingual cortices. Greater thickness in these networks positively correlated with the AQ-hostility subscale and negatively correlated with AQ-anger subscale.Conclusions: The opposite patterns observed between areas belonging to AN, FPN, CON, and the two facets of IA, namely anger and hostility, corroborate clinical findings supporting the different nature of these two constructs.
Intraluminal Monitoring of Micro Vessels. A Surgical Feasibility Study
Authors: Walle Leonard , Sudhoff Holger , Frerichs Onno , Todt Ingo 
Published: July 2021

Objective: Monitoring of vessel perfusion is of high clinical importance in vascular anastomosis of free flaps. Current sensor systems are based on different principles and show limitations in validity and accuracy. Fiber optic pressure sensors exhibit high accuracy and are small in size. The aim of the present study was to evaluate the surgical feasibility of intraluminal pressure (ILP) measurements with a fiber optic pressure sensor in an animal model.Methods: In a microsurgical setting we sedated 10 Wistar rats with weight adapted phenobarbital, xylazine, and fentanyl. We performed a surgical approach to A. carotis communis and V. jugularis and introduced a 600 μm fiber optic pressure sensor into the vessels followed by measuring the ILP. The sensor was stabilized by the surrounding tissue, and the vessels were closed.Results: In all cases, surgical placement was uneventful. Measurement of intra-venous and intra-arterial pressure was possible and stable over the whole measurement period of an hour.Conclusion: Fiber optic pressure measurement in microvessels is possible and surgically feasible. An application to monitor the perfusion of free flaps seems possible.
Enhanced Recovery After Surgery for Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Systematic Review and Meta-Analysis
Authors: Mao Feng , Huang Zhenmin 
Published: July 2021

Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising approach for the management of peritoneal carcinomatosis, but is associated with significant morbidity and prolonged hospital stay. Herein, we review the impact of Enhanced recovery after surgery (ERAS) protocol on length of stay (LOS) and early complications in patients undergoing CRS and HIPEC for peritoneal carcinomatosis.Methods: PubMed and Embase were searched for studies comparing ERAS protocol with control for CRS + HIPEC. Mean difference (MD) and risk ratios (RR) were calculated for LOS and complications respectively.Results: Six retrospective studies were included. Meta-analysis indicated statistically significant reduction in LOS with ERAS (MD: −2.82 95% CI: −3.79, −1.85 I2 = 29% p &lt; 0.00001). Our results demonstrated significantly reduced risk of Calvien Dindo grade III/IV complications with the use of ERAS protocol as compared to the control group (RR: 0.60 95% CI: 0.41, 0.87 I2 = 0% p = 0.007). Pooled analysis of limited studies demonstrated no statistically significant difference in the risk of reoperation (RR: 1.04 95% CI: 0.54, 2.03 I2 = 50% p = 0.90) readmission (RR: 0.55 95% CI: 0.21, 1.49 I2 = 0% p = 0.24), acute kidney injury (RR: 0.55 95% CI: 0.28, 1.10 I2 = 0% p = 0.09) or mortality (RR: 0.62 95% CI: 0.17, 2.26 I2 = 0% p = 0.46) between the study groups.Conclusion: For CRS + HIPEC, ERAS is associated with significantly reduced LOS along with lower incidence of complications. Limited data suggest that use of ERAS protocol is not associated with increased readmission, reoperation, and mortality rates in these patients. There is a need for randomized controlled trials to corroborate the current evidence.
DEEP LEARNING WITH LONG-TERM SHORT-TERM MEMORY FOR IOT TRAFFIC PREDICTION
Authors: БОРОДИН А.С. , АБДЕЛЛАХ А.Р. , КУЧЕРЯВЫЙ А.Е. 
Published: July 2021

Использование искусственного интеллекта в сетях связи пятого (5G) и последующих поколений дает новые возможности, в том числе для прогнозирования трафика. Это особенно важно для трафика интернета вещей (IoT - Internet of Things), поскольку число устройств IoT очень велико. Предлагается для прогнозирования трафика IoT применить глубокое обучение с использованием нейронной сети долговременной краткосрочной памяти LSTM (Long Short-Term Memory).
The use of artificial intelligence in communication networks of the 5G and subsequent generations provides completely new opportunities, including for traffic forecasting. This is especially important for IoT traffic because the number of IoT devices is very large. The article proposes to apply deep learning to predict IoT traffic using a neural network of longterm short-term memory (LSTM).
TRANSMISSION OF SHORT MESSAGES IN SATELLITE COMMUNICATION SYSTEMS WITH PERMUTATION MODULATION AND REED-SOLOMON CODES
Authors: БЫХОВСКИЙ М.А. 
Published: July 2021

В статье выполнено исследование возможности создания энергетически эффективных систем связи, предназначенных для передачи коротких сообщений длиной 50...1000 бит по каналу связи, в которых применяются ансамбли сигналов с перестановочной модуляцией, а также коды Рида-Соломона. Полученные результаты показали, что рассмотренные системы связи при вероятности ошибки декодирования принятого сообщения, равной Pdec=10-6 , имеют существенный энергетический выигрыш (примерно 2,6 дБ) по сравнению с системами, в которых используются сигналы с модуляцией 2-PSK, коды с малой плотностью проверок на четность (LDPC), турбокоды и др. Кроме того, показано, что системы связи, в которых для передачи коротких сообщений применяются ансамбли сигналов, оптимальных по Шеннону, энергетически эффективнее по сравнению с системами, в которых для этого используются традиционные методы модуляции и помехоустойчивые коды. Применение оптимальных по Шеннону ансамблей позволяет существенно сократить длительность сигналов при передаче такого же количества бит, которое может быть передано по каналу связи традиционными методами.
The article investigates the possibility of creating energy-efficient communication systems designed to transmit short messages 50...1000 bits long via a communication channel in which signal ensembles with permutation modulation (PM) are used, as well as Reed-Solomon (RS) codes. The results obtained showed that the considered communication systems with a probability of decoding error of the received message equal to Pdec=10-6 have a significant energy gain (approximately 2.6 dB), in comparison with systems that use signals with 2-PSK and LDPC codes, turbo codes, etc. It is shown that communication systems using Shannon-optimal signal ensembles for short message transmission are more energy efficient than systems using traditional modulation methods and noise-resistant codes. The use of Shannon-optimal ensembles can significantly reduce the duration of signals when transmitting the same number of bits that can be transmitted over the communication channel by traditional methods.