bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of serum lipid profile and apolipoprotein in patients with concurrent gallbladder stone disease and type 2 diabetes mellitus: a population-based study in China
Authors: Liang Song , Jiang Pin , Feng Xue-Yi , Zhai Rong-rong , Yang Li , Li Xiao-qi , Xu Xun , Fang Xin-An , Liang Yong-Kang 
Published: March 2021

Abstract
Background

Gallbladder stone diseases being common disorder, prior studies have identified an association between gallstones and abnormal lipids, type 2 diabetics have higher rates of significant abnormalities in lipid metabolism, so the prevalence of dyslipidemia may be higher in gallstone disease patients with type 2 diabetes mellitus (T2DM) than in the general population. The aim of this study was to compare the serum lipid and lipoprotein abnormalities between gallbladder stone patients who have T2DM and controls in China.
Methods

Retrospective analysis of serum lipid and apolipoprotein levels in patients aged 40 years and older with gallbladder stone combined with T2DM, T2DM, gallbladder stone and normal group of 407 individuals in four groups. 135 cases with gallbladder stones combined with T2DM were compared with 102 cases with T2DM, 119 cases with gallbladder stone and 51 normal individuals respectively among four groups. Triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), very low-density lipoprotein (VLDL), serum apolipoprotein (apo) AI (ApoAI), apolipoprotein (apo) B (ApoB) and their ratio (ApoAI/ApoB) were collected from the four groups and compared. One-way ANOVA and nonparametric tests (Kruskal-Wallis tests) were used to compare groups. P < 0.05 was considered statistically significant.
Results

Compared to three control groups, the patients over 40 years old with gallbladder stone combined with T2DM had significant abnormal changes in lipids: the LDL and APoB levels were significantly raised in patients with gallbladder stones combined with T2DM (P < 0.05), and in males LDL levels were significantly higher in gallbladder stones patients with concomitant T2DM (P < 0.05).
Conclusions

The study showed that LDL and APoB levels were statistically significant in patients over 40 years of age with concurrent gallbladder stone disease and T2DM, with male patients having significantly higher LDL levels but no statistically significant parameters were found in female patients.
A Novel Oral Edaravone Formulation Partially Alleviates Tau Pathology and Motor Deficits in an Animal Model of Frontotemporal Dementia
Authors: Kelliny Sally , Xiong Jing , Bobrovskaya Larisa , Zhou Xin-Fu 
Published: March 2021

Abstract
Oxidative stress (OS) is a key factor in the pathogenesis of several neurodegenerative disorders and is involved in the accumulation of amyloid beta plaques and Tau inclusions. Edaravone (EDR) is a free radical scavenger that is approved for motor neuron disease and acute ischemic stroke. EDR alleviates pathologies and cognitive impairment of AD via targeting multiple key pathways in transgenic mice. Herein, we aimed to study the effect of EDR on Tau pathology in an animal model (P301L mice) of frontotemporal dementia (FTD) at two age time points representing the early and late stages of the disease. A novel EDR formulation was utilized in the study and the drug was delivered orally in drinking water for 3 months. Then, behavioral tests were conducted followed by animal sacrifice and brain dissection. Treatment with EDR improved the cognitive deficits as evaluated in Morris water maze, novel object recognition and significantly alleviated motor deficits in these mice. EDR also reduced the levels of 4-hydroxy-2-nonenal (4-HNE) and 3-nitrotyrosine (3-NT) adducts. In addition, immunohistochemistry showed that EDR reduced tau phosphorylation and neuroinflammation and partially rescued neurons against oxidative neurotoxicity. Moreover, EDR attenuated downstream pathologies involved in Tau hyperphosphorylation. These results suggest that EDR may be a potential therapeutic agent for the treatment of FTD.
A Physico-Chemical&nbsp;Approach To Understanding&nbsp;Cosmic&nbsp;Evolution: Thermodynamics&nbsp;&nbsp;Of&nbsp;Expansion And Composition Of The Universe
Authors: Melendres Carlos A. 
Published: March 2021

Abstract
We present a physico-chemical approach towards understanding the mysteries associated with the Inflationary Big Bang model of Cosmic evolution based on a theory that space consists of energy quanta. We use thermodynamics to elucidate the expansion of the universe, its composition, and the nature of dark energy and dark matter. The universe started from an atomic size volume of space quanta at very high temperature. Upon expansion and cooling, phase transitions resulted in the formation of fundamental particles, and matter which grow into stars, galaxies, and clusters due to gravity. From cooling data on the universe, we constructed a thermodynamic phase diagram of composition of the universe, from which we obtained a correlation between dark energy and the energy of space. Using Friedmann’s equations, our Quantum Space model fitted well the WMAP data on cosmic composition with an equation of state parameter, w= -0.7. The expansion of the universe was adiabatic and decelerating during the first 7 billion years after the Big Bang. It accelerated due to the dominance of dark energy at 7.25 x 109 years, in good agreement with BOSS measurements. Dark Matter is identified as a plasma form of matter similar to that which existed before recombination and during reionization.
Screen-printing of microfibrillated cellulose for an improved moisture management, strength and abrasion resistant properties of flame-resistant fabrics
Authors: Kokol Vanja , Vivod Vera , Peršin Zdenka , Kamppuri Taina , Dobnik-Dubrovski Polona 
Published: March 2021

Abstract
Low moisture absorbency of hydrophobically coated flame-resistant (FR) fabrics do not correlate well with the thermophysiological comfort. In this frame, we were the first to study the effect of screen-printed microfibrillated cellulose (MFC) on fabric’s breathability and moisture build-up and transfer as user-friendly and wear-related comfortable coating. The amount of MFC applied and its patterning was varied using different printing parameters, and the density and thickness of FR fabric, and studied by add-on measurement and microscopic imaging. The effect of MFC coating and its durability (attachment) after a post-printing of hydrophobic polyacrylate on the same (layer-by-layer) or other side of the fabrics was considered, thus to maintain one side of the fabric (facing towards the wearer) hydrophilic while keeping the other side (facing outward) hydrophobic. The results showed that MFC provides uniform and repeatable printing, which gave homogeneous patterning with good layering on the fabrics, although, resulting in the MFC concentration, squeegee’ pressure, and fabric’ structure dependent add-on, its imprinting and co-crosslinking within the polyacrylate. This slightly reduced the fabric air-permeability, but increased it surfaces wetting, moisture uptake kinetic and capacity (hydroscopicity), without affecting the water vapour transfer. Besides, the polyacrylate could fix the MFC pre-printed on the other side of the fabric, thus maintaining its hydrophilicity, being more pronounced in the case of less open and thicker fabric, while improving its tensile /tear strengths and abrasion resistance, without deterioration of the fabric`s flammability.
“An Approach for Intersection Prevention in Transmission Channel Using Correlation Matrix and Tree Construction Model in V2x Framework”
Authors: T GraceShalini , S Jenicka 
Published: March 2021

Abstract
Typically, the delivery of information in vehicular ad hoc networks (VANETs) is regarded as a demanding one because of high mobility and invariable topological difference. One major concern in VANET framework is the occurrence of simulated intersection at which the packet reception probability become complicated for predicting and the model turn out to be complex highly. So as to overcome this dispute, a new framework is introduced which in turn prevents the intersection among the transmission path. Initially, the system model is initialized and the availability of channel is estimated. Based on the strength and size of data to be transmitted, the availability of channel is computed. After that, the best forwarding zone computation is made for minimizing the redundant data packets flow. To check the priority of packet and occurrence of packet collision, tree construction based data strength transmission is employed. at last, the prevention of intersection or collision between the transmission channel is checked by means of correlation matrix based intersection prevention approach by monitoring the neighbor node. Then, the data packets were forwarded in an efficient manner without any intersection between the frames. The performance analysis is estimated in terms of network lifetime, packet delivery ratio, packet collision; inter node collision, throughput, and end-to-end delay.
False-Negative Frozen Section of Sentinel Nodes in Early Breast Cancer Patients
Authors: Loh Zhu-Jun , Lee Kuo-Ting , Chen Ya-Ping , Kuo Yao-Lung , Chung Wei-Pang , Hsu Ya-Ting , Huang Chien-Chang , Hsu Hui-Ping 
Published: March 2021

Abstract
Background: Sentinel lymph node biopsy (SLNB) is the standard approach of the axillary region for early breast cancer patients with clinically negative nodes. The present study investigated patients with false-negative sentinel nodes of intraoperative frozen section (FNSNs) in real-world data.Methods: A case–control study with a 1:3 ratio was conducted. FNSN was diagnosed when sentinel nodes (SNs) are negative in frozen sections but positive for metastasis in formalin-fixed paraffin-embedded (FFPE) sections. The control was defined as having no metastasis of SNs in both frozen and FFPE sections.Results: A total of 20 FNSN cases and 60 matched controls were enrolled from 333 SLNB patients between April 1, 2005, and November 31, 2009. The demographics and intrinsic subtypes of breast cancer were similar between FNSN and controls. The FNSN patients had larger tumor sizes in preoperative mammography (P = 0.033) and more lymphatic tumor emboli in core biopsy (P < 0.001). Four FNSN patients had metastasis in the non-relevant SNs. Another 16 FNSN patients had benign lymphoid hyperplasia of SNs in frozen sections and metastasis in the same SNs from the FFPE sections. Micrometastasis was detected in seven of 16 patients, and metastases in non-relevant SNs were recognized in two patients. All FNSN patients received a second operation with axillary lymph node dissection (ALND). After a median follow-up of 143 months, no FNSN patients developed recurrence of breast cancer. The disease-free survival, disease-specific survival, and overall survival in FNSN were not inferior to the controls.Conclusions: The patients with a larger tumor size and more lymphatic tumor emboli have a higher incidence of FNSN. However, outcomes of FNSN patients after completing ALND were noninferior to those without metastasis in SNs. ALND provides a correct diagnosis of patients with metastasis in non-sentinel axillary lymph nodes.
Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis
Authors: Tito Cecilia , Silvatti Juliana , Almeida Izabela N. F. , Taniguchi Elise V. , Prata Tiago , Paranhos Augusto , Kayser Cristiane 
Published: March 2021

Abstract
PurposeVasospasm represents an early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve head (ONH) damage and has been involved in the pathogenesis of glaucoma, especially normal-tension glaucoma (NTG). We aimed to investigate the presence of structural abnormalities associated with NTG using swept-source optical coherence tomography (SS-OCT) and to correlate the OCT parameters with clinical, capillaroscopy and digital blood flow measures in patients with SSc. MethodsIn this cross-sectional study, 40 patients with SSc and 23 age-matched controls were included. The following parameters were measured using SS-OCT: mean and sectoral retinal nerve fiber layer (RNFL) thickness, macular ganglion cell layer complex (GCC) thickness and ONH morphology. Nailfold capillaroscopy (NFC) and digital blood flow measurements using laser Doppler imaging (LDI) were performed in all subjects. ResultsPatients with SSc showed a thinner temporal RNFL than the controls (69.23 ± 11.74 versus 83.35 ± 20.19 µm, p=0.001). The other parameters were similar between the two groups. In SSc patients, there was an inverse correlation between the disease duration and the average, superior and inferior RNFL thickness and the GCC thickness and between Raynaud’s phenomenon duration and the average RNFL and GCC thickness (p<0.05). NFC and LDI measurements did not show correlations with OCT parameters.ConclusionA thinner temporal RNFL and the correlation between Raynaud’s phenomenon and disease duration and structural abnormalities on OCT suggest the presence of early ganglion cell damage in patients with SSc. Although mild, these findings indicate the need to monitor ocular abnormalities in SSc.
Activation of the PX1/IL-1β axis in CD41+/CD62P+ platelets enhances pancreatic ductal adenocarcinoma invasion and metastasis
Authors: Li Hao , Jiang Wang , Zhang Shirong , Xu Huaxiang , Li Pengcheng , Li Tianjiao , Jin Wei , Quan Dexian , Yang Yiming , Ye Longyun , Xu Shuaishuai , Yu Xianjun , Liu Liang 
Published: March 2021

Abstract
The pro-tumor mechanisms of platelets in pancreatic ductal adenocarcinoma (PDAC) are poorly understood. We showed that the count of the CD41+/CD62P + platelets subtype was significantly elevated in stage III/IV patients. An increased level of CD41+/CD62P + platelets could serve as an independent risk factor for stage I/II patients after surgery. Furthermore, we found significantly higher PX1 expression in CD41+/CD62P + platelets than in CD41+/CD62P- platelets in PDAC patients. Mechanistically, PX1 was able to enhance IL-1β secretion in platelets via phosphorylating p38 MAPK and consequently promoted PDAC invasion and metastasis. Finally, we constructed a novel compound named PC63435 by the ligation of carbenoxolone (PX1 inhibitor) and PSGL-1 (CD62P ligand). PC63435 specifically bound to CD41+/CD62P + platelets and blocked the PX1/IL-1β pathway, which suppressed PDAC tumor invasion and metastasis. Our findings revealed that the activation of PX1 in CD41+/CD62P + platelets enhanced PDAC cell malignancy and that may be a potent target for PDAC therapy.
Comprehensive Analysis of Key Genes and Regulatory Elements in Ewing Sarcoma With Prognostic Values
Authors: Li Mi , Li Hao , Zong Yan , Wang TingXin , Deng Sisi , Yang Caihong 
Published: March 2021

Abstract
Background: Ewing sarcoma (ES) is one of the most common types of round cell mesenchymal neoplasms related to children and young adults. It is characterized by chromosomal translocations. However, that does not completely explain the ES proliferation and development. Methods: Several public data series (GSE45544, GSE68591, and GSE68776) were used to identify differentially expressed genes (DEGs) between ES and normal tissue. Furthermore, functional enrichment analysis and protein-protein interaction network of DEGs were performed. The regulatory network of DEGs and hub genes, survival analysis of hub genes was visualized. In addition, functional predictions of the candidate gene were analyzed. Results: A total of 142 DEGs 10 hub genes were identified. While out of them, only one candidate gene FGF7 was found to be suitable as a candidate gene. Conclusions: In conclusion, the DEGs, hub genes, and their regulatory molecules screened out in this research could contribute to comprehend the mechanisms in ES and provide potential research molecular for further study.
Metabolic Syndrome and Its Components Reduce Coronary Collateralization in Chronic Total Occlusion: an Observational Study
Authors: Liu Tong , Wu Zheng , Liu Jinghua , Lv Yun , Li Wenzheng 
Published: March 2021

Abstract
Background: Metabolic syndrome (METs) is an independent risks for the incidence of cardiovascular diseases. We investigated whether or to what extent the METs and its components was associated with coronary collateralization (CC) in chronic total occlusion (CTO).Methods: This study involved 1709 inpatients with CTO. Data on demographic and clinical characteristics were collected by cardiovascular doctors. The CC condition was defined by Rentrop score system. Subgroup analysis, mixed models regression analysis, score systems and receiver-operating characteristic curves (ROC) analysis were done. Results: Overall, 1709 inpatients were assigned to the Poor CC group (n = 370), good CC group (n = 1339) with or without METs. Compared to good CC, the incidence of METs was higher in poor CC for overall patients. Poor collateralization was present in 9.1%, 14.4%, 19.9%, 18.1%, 35.1% and 54.2% of the six groups, who met the diagnostic criteria of MetS 0, 1, 2, 3, 4 and 5 times. For multivariable logistic regression, quartiles of BMI remained the risk factors of CC growth in all subgroups (adjusted OR = 1.728, 95% CI 1.518-1.967, P < 0.001 all patient group , adjusted OR = 1.827, 95% CI 1.484-2.249, P < 0.001 No-METs group and adjusted OR = 1.771, 95% CI 1.484-2.115,P < 0.001 METs group). After adjustment for potential confounding factors, METs was an independent risk factors of CC growth in several models. Assigning a score of one for each components, this score system had significant predictive value for the CC conditions by Receiver-operating characteristic(AUC: 0.622, 95%CI: 0.588-0.655) .Conclusions: METs, especially for body mass index, confers greater risk for CC formation in CTO. Score systems may help to predict CC condition.
Acute Intestinal Necrosis due to Diaphragmatic Hernia after Radiofrequency Ablation for Hepatocellular Carcinoma: A Case Report and Literature Review
Authors: Li Yaoqing , Shen Liyijing , Tao Kelong , Yu Shanlu , Xu Guangen 
Published: March 2021

Abstract
Background: Radiofrequency ablation is widely used as an effective and minimally invasive treatment of hepatocellular carcinoma. The complications of radiofrequency ablation are mainly associated with needle damage or local thermal damage, while the reports of long-term complications of radiofrequency ablation are relatively rare.Case Report: This report presents a case of hepatocellular carcinoma with diaphragmatic hernia after radiofrequency ablation. A 60-year-old male came to the hospital with sudden abdominal pain for one day, who had received radiofrequency ablation and transcatheter arterial chemoembolization treatment for hepatocellular carcinoma located in segment 8 as an initial treatment 52 months ago. Computed tomography showed the right diaphragmatic hernia, small intestine intruding into the chest with intestinal obstruction. The patient underwent an emergency diaphragmatic repair with bowel resection and was successfully discharged 1 week after the operation.Conclusion: Diaphragmatic hernia is a long-term complication of radiofrequency ablation. Surgical treatment is recommended as the first choice when conditions permitted.
Data Element Mapping to Analyze Fit for Use of Three XML Standards for Health Workforce Tracking
Authors: Opalek Amy 
Published: March 2021

Abstract
Background: Ensuring a sufficient supply and distribution of health care professionals is essential to meeting public health needs. Regulatory agencies protect their communities by ensuring that new health professionals have the required qualifications to practice safely and by tracking the volume and distribution of those professionals on an ongoing basis. The speed and accuracy of sharing these data could be greatly improved through the adoption of a data standard for information about health professionals. To date, however, no internationally accepted standard has emerged for this purpose. Purpose: This study examines three existing XML standards designed for the representation of individual worker data to determine if, and to what degree, each could be used for the tracking of health professionals. Methods: The data elements of the Europass schema, the HR Open Standard Recruiting specification, and the MedBiquitous Healthcare Professional Profile standard were fully examined and matching elements were mapped to the 200+ elements identified from a prior content analysis as required by a sample of 20 international regulatory agencies.Results: None of the schemas examined addressed more than half of the information elements required by regulators. All three schemas are found lacking in some key areas of interest, especially vital information that could disqualify ineligible applicant practitioners.Conclusions: The three standards could all be improved by including new elements essential to regulatory agencies. Regulatory agencies should be consulted in the development of new standards for representing potentially disqualifying information about candidates for professional practice.
Prediction of Building Orientation Effects Through Machine Learning Process of Additively Manufactured Triply Periodic Minimal Surface Scaffolds
Authors: Assis Matheus Mendes da Silva de , Conte Erik Gustavo del 
Published: March 2021

Abstract
Triply periodic minimal surfaces (TPMS) are porous structures which can be used to create multifunctional materials for various technological applications. TPMS have a complex geometry, therefore, additive manufacturing is shown as the ideal method for their manufacturing, due to the flexibility of such method. Thus, this work aims to predict the building orientation effects through machine learning process of additively manufactured triply periodic minimal surface scaffolds. DOE (Design of experiments) was used to determine the effect of the 30°, 60° and 90° angles of the X, Y and Z axes of the TPMS and ANOVA (Analysis of variance) to determine the relevant statistical interactions. Subsequently, the Multi-Layer Perceptron, Random Tree and Multiple Linear Regression machine learning algorithms were used through WEKA software to predict the cost and support material consumption for each TPMS. The results showed that the cost of TPMS can vary between about 12 and 15% according to the most expensive to the most economical building orientation. The Multiple Linear Regression algorithm obtained the best result for the cost prediction and in the support material consumption prediction the Multi-Layer Perceptron algorithm got the best.