bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA-Sequencing-Based lncRNA Biomarker Profiling on Triple Negative Breast Cancer
Authors: Gao Lin , Yang Qinhe , Zhou Wenbin , Dai Yong , Wang Jigang , Fu Li , Zhao Pan , Huang Jingy , Hong Malin , Xia Jinquan , Zou Chang 
Published: September 2021

Abstract: Basal-like triple-negative breast cancer (TNBC) is highly heterogeneous and lack of effective molecular targets for therapy. In this study, we developed the lncRNA signatures of TNBC as molecular biomarkers. RNA-sequencing in 12 paired breast cancer and adjacent tissues identified up-regulated and down-regulated lncRNAs of Basal subtype in contrast to Luminal A, Luminal B and HER2 subtypes. Additionally, Kaplan-Meier analysis revealed that high expression of lncRNA (ZEB1-AS1 and TMEM254-AS1) had a poor relapse-free survival rate (RFS), while high expression of lncRNA (LINC01087, LINC01122 and LINC00856) had a positive correlation with RFS. Furthermore, qRT-PCR analysis showed that the mRNA expressions of the ZEB1-AS1 and TMEM254-AS1 lncRNA were up-regulated in TNBC tissues, while the mRNA expression of lncRNA, including LINC01087, LINC01122 and LINC00856 were down-regulated in TNBC tissues. Taken together, our results elucidated that 5 novel lncRNAs, including ZEB1-AS1, TMEM254-AS1, LINC01087, LINC01122 and LINC00856 contributed to the progression of invasive TNBC. These lncRNAs could be molecular biomarkers for the development of TNBC treatment.
Keywords: TNBC, long noncoding RNA (lncRNA), RNA-sequencing, ZEB1-AS1, TMEM254-AS1, LINC01087, LINC01122, LINC00856.
Resultados comparativos de la prueba saber 11 antes y durante la pandemia por COVID-19 en una institución educativa de Soacha, Cundinamarca, Colombia
Authors: Díaz Pinzón Jorge Enrique 
Published: September 2021

Introducción: la afección por coronavirus 2019 (COVID-19) es una enfermedad respiratoria aguda infecciosa CAUSADA por un nuevo coronavirus. La Organización Mundial de la Salud (OMS) fue conocedora de casos de neumonía de etiología microbiana irreconocible, asociados con la ciudad de Wuhan, provincia de Hubei, China, el 31 de diciembre 2019. Objetivo: comparar los resultados de las pruebas Saber 11- 2019 y 11- 2020 durante la pandemia del COVID-19 en la institución educativa General Santander del municipio de Soacha, Cundinamarca, Colombia. Metodología: trabajo de tipo experimental, la información se obtuvo de los resultados de las pruebas Saber 11, 2019 y 2020. Resultados: los promedios en las diferentes asignaturas evaluadas en la prueba no tuvieron diferencias significativas, es decir que no se evidenció una disminución en el resultado global de la prueba en dicha institución. Conclusión: el hecho de que no haya diferencias significativas entre los años 2019 y 2020 radica también en que los estudiantes pertenecen al mismo contexto social y económico.
Teaching in the Subject “Systems Interconnection” at Extremadura University
Authors: Masa Juan Arias , Espada Rafael Martín , Abelaria Juan Arias 
Published: September 2021

This work describes the teaching that is used in the subject of "Systems Interconnection" that is taught in the Higher Telecommunications Engineering of the University of Extremadura. Each of the sections that make up the subject are detailed, both the competences that the students will have as soon as they pass the subject, as well as the theoretical and practical contents taught therein. In addition, a summary is made of the teaching methodology used, the learning results, and finally ends detailing the evaluation methodology and above of all the academic results of the last courses, where an improvement in these results is observed, especially in the percentage of approved by reducing the sum of the percentages of unchanged and suspended.
APROVEITAMENTO DA ÁGUA DO PROCESSAMENTO DOS FRUTOS DE CAFÉ NA FERTIRRIGAÇÃO DE Brachiaria mutica
Authors: Emerick Michell Bahia Dutra , Barbosa Rodolfo Alves , Moreli Ademar Polonini , Soares Sammy Fernandes , Reis Edvaldo Fialho dos 
Published: September 2021

Considerando que a aplicação da água do processamento de café (APC), via fertirrigação, pode promover alterações nos teores de K do solo, na planta e na produção de massa seca do Brachiaria mutica (Capim Angola), realizou-se um trabalho com o objetivo de avaliar os teores disponíveis de K no perfil de um Neossolo Flúvico, na planta, e na produção de massa seca do capim angola decorrentes da aplicação de diferentes doses de APC. As parcelas receberam cinco tratamentos sendo: doses de APC 0, 57, 114, 171 e 228m³/ha, calculados de forma que a dose 114m³/ha elevasse o teor de K a 5% na CTC (T) do solo. Foram coletadas amostras de solo, aos 45 e 90 dias após a aplicação da APC, nas profundidades de 0 a 20 cm; 20 a 40 cm; 40 a 60 cm e 60 a 80 cm. Realizado também coletas, no mesmo período, de amostras para análise foliar e de massa seca. O uso da APC, na dose de 114 m³/ha promoveu incremento de K no solo apenas na camada de 0-20 cm. Observou-se ainda incremento em camadas inferiores mediante dosagens superiores. Não houve diferença na produção de biomassa e teores de nutrientes na planta, mediante os diversos tratamentos.
Palavras-chave: pós-colheita; nutrição; lixiviação; potássio.

Use of water for processing coffee beans in the fertigation of Brachiaria mutica

ABSTRACT: Considering that the application of water from coffee processing (WCP), via fertigation, can promote changes in the K content of the soil, in the plant and the production of the dry mass of Brachiaria mutica (Capim Angola), work was carried out to evaluate evaluating the available levels of K in the profile of a Floss Neossol, in the plant, and the production of the dry mass of the Angola grass resulting from the application of different doses of WPC. The plots received five treatments: WPC doses 0, 57, 114, 171, and 228m³ / ha, calculated so that the 114m³ / ha dose raised the K content to 5% in the CTC (T) of the soil. Soil samples were collected at 45 and 90 days after WPC application, at depths of 0 to 20 cm; 20 to 40 cm; 40 to 60 cm and 60 to 80 cm. Samples for leaf analysis and dry mass were also collected in the same period. The use of WPC, at a dose of 114 m³ / ha, increased K in the soil only in the 0-20 cm layer. An increase was also observed in lower layers through higher dosages. There was no difference in the production of biomass and nutrient contents in the plant, through the different treatments.
Keywords: Post-harvest; nutrition; leaching; potassium.
DESEMPENHO DE CULTIVARES DE TOMATE ITALIANO DE CRESCIMENTO DETERMINADO EM CULTIVO PROTEGIDO SOB ALTAS TEMPERATURAS
Authors: Trento Daiane Andréia , Tiago Antunes Darley , Fernandes Júnior Flávio , Roggia Zanuzo Márcio , Dallacort Rivanildo , Seabra Júnior Santino 
Published: September 2021

O objetivo desse trabalho foi avaliar a produção, a qualidade e tempo de prateleira de cultivares de tomate tipo italiano de crescimento determinado, produzidos sob ambiente protegido em condições de altas temperaturas. O cultivo foi realizado em Nova Mutum – MT, foram avaliados cinco cultivares: Fascínio (Feltrin sementes), Hy Color (Horticeres), Santa Adélia (TopSeed), SM-16 (Seminis) e Supera F1 (TopSeed), dispostos em blocos casualizados, com quatro repetições. As plantas foram conduzidas em “meia estaca” e não foram podadas. Os parâmetros avaliados foram relativos a produção, a qualidade dos frutos, tempo de prateleira e qualidade no pós-colheita. A cultivar Fascínio apresentou produtividade de 186,1 t ha-1, maior massa média de frutos (144,3g), maior calibre de fruto, (60,7mm), e menor perda de massa no pós-colheita (6,23%). Os melhores resultados de sólidos solúveis totais dos frutos que completaram a maturação na planta foram obtidos das cultivares Santa Adélia (4,3), Fascínio (4,27) e Hy Color (4,21), e dos frutos colhidos no estádio verde-maduro obteve destaque a cultivar Santa Adélia (5,85), e os frutos que ficaram em temperatura ambiente obtiveram maior média de sólidos solúveis totais (5,55).
Palavras-chave: termotolerância; Lycopersicum esculentum Mill; produtividade; pós colheita; ambiente protegido.

The performance of determinate growth italian tomato cultivars in protected cropping under high temperatures

ABSTRACT: This study aimed to evaluate the production, quality and shelf time of determinate growth Italian tomato cultivars from a protected environment under high temperature conditions. The cultivation was conducted in Nova Mutum, state of Mato Grosso, Brazil. Five cultivars were evaluated: ‘Fascínio’ (Feltrin Sementes), ‘Hy Color’ (Horticeres), ‘Santa Adélia’ (TopSeed), ‘SM-16’ (Seminis) and ‘Supera F1’ (TopSeed), disposed in randomized blocks with four repetitions. The plants were managed into the “meia estaca” tutoring method and were not pruned. The parameters evaluated were related to the production, quality of fruits, shelf time and postharvest quality. The ‘Fascínio’ cultivar presented productivity of 186.1 t ha-1, the largest average fruit weight (144.3 g), the largest fruit gauge (60.7 mm) and the smallest postharvest weight loss (6.23%). The total soluble solids best results of fruits that have matured in the plant were obtained from the ‘Santa Adélia’ (4.3), ‘Fascínio’ (4.27) e ‘Hy Color’ (4.21) cultivars. Among the fruits harvested at the mature-green stage, the ‘Santa Adélia’ (5.85) cultivar stood out. The fruits that stayed at room temperature obtained the largest total soluble solids average (5.55).
Keywords: thermotolerance; Lycopersicum esculentum Mill; productivity; postharvest; protected environment.
NOISE LEVELS EMITTED BY AGRICULTURAL TRACTORS WITH AND WITHOUT IMPLEMENTS ACTIVATION
Authors: Pereira Assis Gomes Amanda , Araújo e Silva Ferraz Gabriel , Bedin Marin Diego , Battemarco da Silva Fabiano , Mendes dos Santos Luana , Ferreira Ponciano Ferraz Patrícia 
Published: September 2021

Níveis de ruído emitidos por tratores agrícolas com e sem acionamento de implementos
Os níveis de ruído emitidos pelas máquinas agrícolas podem ser prejudiciais à saúde do trabalhador e, por vezes, negligenciados no meio rural. Este trabalho teve como objetivo mensurar os níveis de ruído emitidos por três tratores agrícolas de diferentes potências acionando dois tipos de implementos para avaliar se havia riscos à saúde dos operadores e trabalhadores de apoio ao redor da operação. Os dados de ruído foram coletados por decibelímetro em dez pontos de cada lado da máquina (frente, trás, esquerda e direita) para um total de 40 pontos ao redor de cada trator. Três tratores diferentes foram avaliados em diferentes cenários: sem implemento, acoplando e acionando uma esparramadora de corretivo e acoplando e acionando uma enxada giratória. O trator foi estacionado no centro da mistura com uma rotação do motor que garantiu 540 rotações por minuto (RPM). para a tomada de potência (TDP) durante toda a coleta de dados. Os dados foram analisados ​​por meio de gráficos, regressão linear e análise de agrupamento hierárquico. Os resultados indicaram que os níveis de pressão sonora em todas as situações estudadas ultrapassam os limites da norma regulamentadora (NR) 15, tornando os protetores auditivos indispensáveis ​​durante a jornada de trabalho.
Palavras-chave: ergonomia; conforto acústico; mecanização agrícola; nível de pressão sonora.

ABSTRACT: The noise levels emitted by agricultural machines can be harmful to the worker's health, and it is sometimes neglected in rural areas. This work aimed to measure the noise level emitted by three agricultural tractors of different power activating two types of implements to assess whether there were risks to operators' health and the supporter workers around the tractor. The noise level data were collected using a decibel meter in ten points on each machine side (forward, rear, left, and right) for a total of 40 points around each tractor. Three different tractors were evaluated in different scenarios: without any implement, coupling and activating a spreader, and coupling and activating a rotary hoe. The tractor was parked at the centre of the mash with an engine speed that ensured 540 rotation per minute (RPM). to the power take-off (PTO) during the entire data collection. The data were analyzed by charts, linear regression, and hierarchical clustering analysis. The results indicated that the sound pressure levels in all of the studied situation exceed the standard's limits regulatory standard 15, making hearing protectors essential during the working day.
Keywords: ergonomics; acoustic comfort; agricultural mechanization; sound pressure level.
Bilateral open sacroiliac joint fusion during adult spinal deformity surgery using triangular titanium implants: technique description and presentation of 21 cases
Authors: Martin Christopher T. , Holton Kenneth J. , Jones Kristen E. , Sembrano Jonathan N. , Polly David W. 
Published: September 2021

OBJECTIVE
Pelvic fixation enhances long constructs during deformity surgery. Subsequent loosening of iliac screws and pain at the pelvis occur in as many as 29% of patients. Concomitant sacroiliac (SI) fusion may prevent potential pain and failure. The objective of this study was to describe a novel surgical technique and a single institution’s experience using bilateral SI fusion during adult deformity surgery with S2-alar-iliac (S2AI) screws and triangular titanium rods (TTRs) placed with navigation.

METHODS
The authors reviewed open SI joint fusions with TTR performed between August 2019 and March 2020. All patients underwent lumbosacral fusion through a midline approach and bilateral S2AI pelvic fixation in the caudal teardrop, followed by TTR placement just proximal and cephalad to the S2AI screws using intraoperative CT imaging guidance.

RESULTS
Twenty-one patients were identified who received 42 TTRs, ranging in size from 7.0 × 65 mm to 7.0 × 90 mm. Three TTRs (7%) were malpositioned intraoperatively, and each was successfully repositioned during index surgery without negative sequelae. All breaches occurred in a medial and cephalad direction into the pelvis. Incremental operative time for adding TTR averaged 8 minutes and 33 seconds per implant.

CONCLUSIONS
Image-guided open SI joint fusion with TTR during lumbosacral fusion is technically feasible. The bony corridor for implant placement is narrower cephalad, and implants tend to deviate medially into the pelvis. Detection of malpositioned implant is aided with intraoperative CT, but this can be salvaged. A prospective randomized clinical trial is underway that will better inform the impact of this technique on patient outcomes.
The role of postoperative antibiotic duration on surgical site infection after lumbar surgery
Authors: Macki Mohamed , Hamilton Travis , Lim Seokchun , Mansour Tarek R. , Telemi Edvin , Bazydlo Michael , Schultz Lonni , Nerenz David R. , Park Paul , Chang Victor , Schwalb Jason , Abdulhak Muwaffak M. 
Published: September 2021

OBJECTIVE
Despite a general consensus regarding the administration of preoperative antibiotics, poorly defined comparison groups and underpowered studies prevent clear guidelines for postoperative antibiotics. Utilizing a data set tailored specifically to spine surgery outcomes, in this clinical study the authors aimed to determine whether there is a role for postoperative antibiotics in the prevention of surgical site infection (SSI).

METHODS
The Michigan Spine Surgery Improvement Collaborative registry was queried for all lumbar operations performed for degenerative spinal pathologies over a 5-year period from 2014 to 2019. Preoperative prophylactic antibiotics were administered for all surgical procedures. The study population was divided into three cohorts: no postoperative antibiotics, postoperative antibiotics ≤ 24 hours, and postoperative antibiotics > 24 hours. This categorization was intended to determine 1) whether postoperative antibiotics are helpful and 2) the appropriate duration of postoperative antibiotics. First, multivariable analysis with generalized estimating equations (GEEs) was used to determine the association between antibiotic duration and all-type SSI with adjusted odds ratios; second, a three-tiered outcome—no SSI, superficial SSI, and deep SSI—was calculated with multivariable multinomial logistical GEE analysis.

RESULTS
Among 37,161 patients, the postoperative antibiotics > 24 hours cohort had more men with older average age, greater body mass index, and greater comorbidity burden. The postoperative antibiotics > 24 hours cohort had a 3% rate of SSI, which was significantly higher than the 2% rate of SSI of the other two cohorts (p = 0.004). On multivariable GEE analysis, neither postoperative antibiotics > 24 hours nor postoperative antibiotics ≤ 24 hours, as compared with no postoperative antibiotics, was associated with a lower rate of all-type postoperative SSIs. On multivariable multinomial logistical GEE analysis, neither postoperative antibiotics ≤ 24 hours nor postoperative antibiotics > 24 hours was associated with rate of superficial SSI, as compared with no antibiotic use at all. The odds of deep SSI decreased by 45% with postoperative antibiotics ≤ 24 hours (p = 0.002) and by 40% with postoperative antibiotics > 24 hours (p = 0.008).

CONCLUSIONS
Although the incidence of all-type SSI was highest in the antibiotics > 24 hours cohort, which also had the highest proportions of risk factors, duration of antibiotics failed to predict all-type SSI. On multinomial subanalysis, administration of postoperative antibiotics for both ≤ 24 hours and > 24 hours was associated with decreased risk of only deep SSI but not superficial SSI. Spine surgeons can safely consider antibiotics for 24 hours, which is equally as effective as long-term administration for prophylaxis against deep SSI.
Elevated intracranial pressure with craniosynostosis: a multivariate model of age, syndromic status, and number of involved cranial sutures
Authors: Kalmar Christopher L. , Zapatero Zachary D. , Kosyk Mychajlo S. , Carlson Anna R. , Bartlett Scott P. , Heuer Gregory G. , Tucker Alexander M. , Taylor Jesse A. , Lang Shih-Shan , Swanson Jordan W. 
Published: September 2021

OBJECTIVE
Children with multiple prematurely fused cranial sutures and those undergoing surgical correction later in life appear to experience worse neurocognitive outcomes, but it is unclear whether higher intracranial pressure (ICP) is implicated in this process. The purpose of this study was to elucidate the effect of age at intervention and number of involved cranial sutures on ICP, as well as to assess which cranial suture closure may be more associated with elevated ICP.

METHODS
The prospective craniofacial database at the authors’ institution was queried for patients undergoing initial corrective surgery for craniosynostosis in whom intraoperative measurement of ICP was obtained prior to craniectomy. Age, involved sutures, and syndromic status were analyzed in the context of measured ICP by using multiple linear regression.

RESULTS
Fifty patients met the inclusion criteria. Age at procedure (p = 0.028, β = +0.060 mm Hg/month) and multiple-suture involvement (p = 0.010, β = +4.175 mm Hg if multisuture) were both significantly implicated in elevated ICP. The actual number of major sutures involved was significantly correlated to ICP (p = 0.001; β = +1.687 mm Hg/suture). Among patients with single-suture involvement, there was an overall significant difference of median ICP across the suture types (p = 0.008), with metopic having the lowest (12.5 mm Hg) and sagittal having the highest (16.0 mm Hg). Patients with multiple-suture involvement had significantly higher ICP (p = 0.003; 18.5 mm Hg). Patients with craniofacial syndromes were 79.3 times more likely to have multiple-suture involvement (p < 0.001). Corrective surgery for craniosynostosis demonstrated significant intraoperative reduction of elevated ICP (all p < 0.050).

CONCLUSIONS
Syndromic status, older age at intervention for craniosynostosis, and multiple premature fusion of cranial sutures were associated with significantly higher ICP.
Evaluasi Geometrik Tikungan STA 3 + 641 Pada Ruas Jalan Simpang Beringin – Meredan dengan Metode Bina Marga
Authors: H Hardianefil , Lubis Fadrizal , Saleh Alfian 
Published: September 2021

Dengan melihat kondisi fisik ruas jalan Simpang Beringin - Meredan dan di hubungkan dengan peristiwa kecelakaan lalu lintas yang terjadi di ruas jalan tersebut, maka perlu dilakukan tinjauan kondisi ruas jalan tersebut dari segi geometriknya dengan berpedoman pada perhitungan metode Bina Marga. Penelitian dilakukan dengan melaksanakan survey dan pengukuran langsung dilapangan untuk mengetahui kondisi geometrik eksisting tikungan pada jalan tersebut, kemudian dianalisis dengan melakukan perhitungan ulang dengan metode Bina Marga. Dari hasil penelitian pada tikungan STA 3+641 didapat eksisting lengkungan berbentuk full cirle dengan kecepatan kendaraan dilapangan sebesar 40 km/jam dengan jari - jari tikungan R = 82,67 m. Setelah dilakukan perhitungan ulang dengan metode Bina Marga menggunakan jenis lengkung Spiral – Cirle – Sipral dengan kecepatan rencana sebesar 50 km/jam dan jari – jari tikungan Rc = 90 m. Dari hasil perhitungan terdapat perbedaan antara as jalan eksisting dengan as jalan hasil perhitungan Metode Bina Marga dan tidak ditemukan superelevasi yang mengikuti standar perhitungan Bina Marga, sehingga perlu dilakukan perbaikan geometrik pada tikungan tersebut.
PEMENUHAN HAK ANAK YANG TIDAK DIKETAHUI ASAL USULNYA DALAM MEMPEROLEH AKTA KELAHIRAN DI LEMBAGA KESEJAHTERAAN SOSIAL ANAK: (Studi Pada SOS Children’s Village Medan)
Authors: Nurhimmi Falahiyati, Akiruddin Ahmad  
Published: September 2021

Setiap anak berhak atas nama sebagai identitas dirinya dan juga status kewarganegaraan yang merupakan hak dasar dan wajib diberikan negara kepadanya. Identitas diri setiap anak harus diberikan sejak kelahirannya dalam bentuk akta kelahiran. Muncul permasalahan ketika ditemukan anak yang tidak diketahui asal usul dan keluarganya, yang kemudian diasuh oleh Lembaga Kesejahteraan Sosial Anak. Bagaimana dengan pemenuhan hak atas identitas anak tersebut dalam memperoleh akta kelahiran. Untuk mengetahui hal tersebut, maka dilakukan penelitian melalui pendekatan yuridis empiris yang bersifat kualitatif deskriptif dengan tujuan untuk menganalisa implementasi pemenuhan hak anak atas identitas yang diasuh di Lembaga Kesejahteraan Sosial Anak di Kota Medan. Dari penelitian yang dilakukan, ditemukan bahwa masih belum terpenuhinya hak anak yang tidak diketahui asal usulnya yang kemudian diasuh di Lembaga Kesejahteraan Sosial Anak Kota Medan tersebut dalam memperoleh akta kelahiran. Hal ini disebabkan karena Lembaga Kesejahteraan Sosial Anak kesulitan melengkapi Berkas Berita Acara Pemeriksaan Kepolisian perihal penemuan anak yang diminta oleh Dinas Kependudukan dan Catatan Sipil Kota Medan sebagai salah satu persyaratan yang harus dilampirkan.
NEUROPROTECTIVE ACTIVITY OF EXTRACT OF CELERY (APIUM GRAVEOLENS) IN INSILICO STUDY
Authors: Mahendra Reza , Rofik Ainul , Salim Hotimah Masdan , Ulfa Maria , Awwaliyah Evy Silvia 
Published: September 2021

Backround: Celery (Apium graveolens L., Apiaceae) is one of the medicinal plants with secondary metabolite components that have pharmacological effects such as vitamin (choline) content. This study aims to evaluate the mechanism and interaction of choline contained in celery on its effectiveness as a neuroprotective.
Methods: This research is an experimental research using the in silico study.
Results: The insilico search found that the choline content in celery binds to Slc5a7, Chat and Ache. Which has a function in the process of neurotransmitter biosynthesis, neurotransmitter metabolic processes and neurotransmitter secretion processes
Conclusion: The celery (Apium graveolens L., Apiaceae) have pharmacological activity as neuroprotective through the interaction of Slc5a7, Chat and Ache