bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a School-Based Intervention On Levels of Anxiety and Depression: A Cluster-Randomized Controlled Trial of The MindPower Program in Ten High Schools in Norway
Authors: Sælid Gry Anette , Czajkowski Nikolai , Aarø Leif Edvard , Andersen John Roger , Idsøe Thormod , Helleseter Miguel Delgado , Holte Arne 
Published: August 2021

Abstract
BackgroundThe previous decade has shown increased symptoms of depression and anxiety among adolescents. To promote mental health and reduce mental illness, the government of Norway has, as in other countries, pledged that all schools must incorporate life-skills education. We report results from an evaluation of MindPower, a modification of the Coping With Depression (CWD) course, delivered universally in the classroom to secondary high school students, aged 15-16 years, in one county in Norway. The aim of the study was to evaluate the effect of MindPower on symptoms of depression and anxiety.MethodsWe utilized a two-groups` delayed intervention design where 110 first year high school classes were randomized into one of two intervention groups (IG1 and IG2). IG1 participated in MindPower while IG2 served as a control group for four months until the intervention started also in this group. IG1 and IG2 responded to questionnaires before and after the eight weeks course, at the start of the first and the second booster session, and at the five months follow up. Questionnaires, including online versions of the Hopkins Symptom Checklist (SCL-8) and the Reynolds Adolescent Depression Scale (RADS-2:SF), were administered to 1673 out of a total of 2384 students. SCL-levels were also compared with those from a large population study (UngData).ResultsAccording to mixed model analyses, SCL-8 and RADS-2:SF showed significant baseline differences between IG1 and IG2. In IG1 and IG2, both SCL-8 and RADS-2:SF showed a small but significant increase in mean scores throughout the study period, with markedly lower mean scores among boys. The SCL-levels were first lower for both girls and boys and then after the completion of MindPower the SCL-levels, equal to the SCL-levels in UngData.ConclusionsNo effects of the intervention were found. This large universal school-based trial suffered from considerable drop-out of participants. Experiences from implementation and evaluation of universal mental health promotion and preventive school interventions are thoroughly discussed, including, preparation, resources, support, time, realistic expectations, teacher selection and training, implementation, and research designs and more. Several empirically based, practical advices are presented. Clinical Trial registration 27/08/2018. Registration number NCT03647826.
Characteristics and Sources of Environmentally Persistent Free Radicals in PM2.5 in Dalian: Important Role of Polycyclic Aromatic Hydrocarbons
Authors: Li Zhansheng , Zhao Hongxia , Li Xintong , Bekele Tadiyose Girma 
Published: August 2021

Abstract
Environmentally persistent free radicals (EPFRs) are an emerging class of environmental hazardous contaminants that extensively, stably exist in airborne particulate matter and pose harmful effects on human health. However, there was little research about the sources of EPFRs in actual atmospheric conditions. This study reported the occurrence, characteristics and sources of EPFRs and polycyclic aromatic hydrocarbons (PAHs) in PM2.5 collected in Dalian, China. The concentrations of PM2.5-bound EPFRs ranged from 1.13×1013 to 8.97×1015 spins/m3 (mean value: 1.14×1015 spins/m3). Carbon-centered radicals and carbon-centered radicals with adjacent oxygen atoms were detected. The concentration of ∑PAHs ranged from 1.09 to 76.24 ng/m3 and PAHs with high molecular weight (HMW) were predominant species in PM2.5. The correlation analysis and PMF result showed that coal and biomass combustion are the top contributors to EPFR, followed by vehicle emission. The secondary sources to EFPRs was negligible. The finding of present study provides an important evidence for further study on the formation mechanism of EPFRs in actual atmospheric to control the air pollution.
Identification of a Hypoxia - Related lncRNA Signature For The Prognosis of Colorectal Cancer
Authors: HUANG HUA , Xu Shanshan , Li Youran , Gu Yunfei , Ji Lijiang 
Published: August 2021

Abstract
Background: Colorectal cancer (CRC), the commonly seen malignancy, ranks the 3rd place among the causes of cancer-associated mortality. As suggested by more and more studies, long coding RNAs (lncRNAs) have been considered as prognostic biomarkers for CRC. But the significance of hypoxic lncRNAs in predicting CRC prognosis remains unclear.Methods: The gene expressed profiles for CRC cases were obtained based on the Cancer Genome Atlas (TCGA) and applied to estimate the hypoxia score using a single-sample gene set enrichment analysis (ssGSEA) algorithm. Overall survival (OS) of high- and low-hypoxia score group was analyzed by the Kaplan–Meier (KM) plot. To identify differentially expressed lncRNAs (DELs) between two hypoxia score groups, this study carried out differential expression analysis, and then further integrated with the DELs between controls and CRC patients to generate the hypoxia-related lncRNAs for CRC. Besides, prognostic lncRNAs were screened by the univariate Cox regression, which were later utilized for constructing the prognosis nomogram for CRC by adopting the least absolute shrinkage and selection operator (LASSO) algorithm. In addition, both accuracy and specificity of the constructed prognostic signature were detected through the receiver operating characteristic (ROC) analysis. Moreover, our constructed prognosis signature also was validated in the internal testing test. This study operated gene set enrichment analysis (GSEA) for exploring potential biological functions associated with the prognostic signature. Finally, the ceRNA network of the prognostic lncRNAs was constructed.Results: Among 2299 hypoxia-related lncRNAs of CRC in total, LINC00327, LINC00163, LINC00174, SYNPR-AS1, and MIR31HG were identified as prognostic lncRNAs by the univariate Cox regression, and adopted for constructing the prognosis signature for CRC. ROC analysis showed the predictive power and accuracy of the prognostic signature. Additionally, the GSEA revealed that ECM-receptor interaction, PI3K-Akt pathway, phagosome, and Hippo pathway were mostly associated with the high-risk group. 352 miRNAs-mRNAs pairs and 177 lncRNAs-miRNAs were predicted.Conclusion: To conclude , we identified 5 hypoxia-related lncRNAs to establish an accurate prognostic signature for CRC, providing important prognostic markers and therapeutic target.
The SMARTscreen Trial: A Randomised Controlled Trial Investigating The Efficacy of a GP-Endorsed Narrative SMS To Increase Participation in The Australian National Bowel Cancer Screening Program.
Authors: Wood Anna , Emery Jon David , Jenkins Mark , Chondros Patty , Campbell Tina , Wenkart Edweana , O'Reilly Clare , Cowie Tony , Dixon Ian , Toner Julie , Khalajzadeh Hourieh , Gutierrez Javiera Martinez , Govan Linda , Buckle Gemma , McIntosh Jennifer 
Published: August 2021

Abstract
Background: Increasing participation in the Australian National Bowel Cancer Screening Program (NBCSP) is the most efficient and cost-effective way of reducing mortality associated with colorectal cancer by detecting and treating early-stage disease. Currently only 44% of Australians aged 50 -74 years complete the NBCSP. This efficacy trial aims to test whether this SMS intervention is an effective method for increasing participation in the NBCSP. Furthermore, a process evaluation will explore the barriers and facilitators to sending the SMS from general practice.Methods: We will recruit 20 general practices in the western region of Victoria, Australia to participate in a cluster randomised controlled trial. General practices will be randomly allocated with a 1:1 ratio to either a control or intervention group. Established general practice software will be used to identify patients aged 50 to 60 years old who are due to receive a NBCSP kit in the next month. The SMS intervention includes GP endorsement and links to narratives messages about the benefits of and instructions on how to complete the NBCSP kit. It will be sent from intervention general practices to eligible patients prior to receiving the NBCSP kit. We require 1400 eligible patients to provide 80% power with two-sided 5% significance level to detect a 10% increase in CRC screening participation in the intervention group compared to control group. Our primary outcome is the difference in the proportion of eligible patients who completed a faecal occult blood test (FOBT) between the intervention and control group for up to twelve months after the SMS was sent, as recorded in their electronic medical record (EMR). A process evaluation using interview data collected from general practice staff (GP, practice managers, nurses) and patients will explore the feasibility and acceptability of sending and receiving a SMS to prompt completing a NBCSP kit.Discussion: This efficacy trial will provide initial trial evidence of the utility of an SMS narrative intervention to increase participation in the NBCSP. The results will inform decisions about the need for and design of a larger, multi-state trial of this SMS intervention to determine its cost-effectiveness and future implementationTrial registration: Australian New Zealand Clinical Trials Registry: ACTRN12620001020976, 17th October 2020
Assessing the effect of climate change and financial development on agricultural production in ASEAN-4: The role of renewable energy, institutional quality and human capital as moderators
Authors: Chandio Abbas Ali , Shah Muhammad Ibrahim , Sethi Narayan , Mushtaq Zulqarnain 
Published: August 2021

Abstract
This study utilizes the data of ASEAN-4 nations, namely Indonesia, Malaysia, Philippines, and Thailand, to examine how climate change, renewable energy, human capital, institutional quality as well as financial development affect the agricultural production. Since shocks in one country can easily affect another country of this region, the second generation modelling techniques are utilized to prove the relationship among the variables of interest. Findings from the Westerlund (2007) cointegration test confirms long run relationship among the variables. The result from Cross-sectionally augmented autoregressive distributed lag (CS-ARDL) model reveals that climate change negatively affects the agricultural production, renewable energy, human capital, institutional quality positively affects the agricultural production. Moreover, renewable energy use, human capital and intuitional quality moderates the effect of carbon emission on agricultural production. In addition, a U shaped relationship between financial development and agricultural production is discovered, suggesting that financial development can promote production in the agricultural sector only after reaching a certain threshold. Finally, some policy recommendations are provided for the ASEAN-4 countries.
Validity of Triply Labelled Water Analysis for Energy Expenditure Measurements in Mice
Authors: Wang Xing , Kong Dehuang , Dijk Gertjan van , Meijer Harro 
Published: August 2021

Abstract
The Doubly Labelled Water (DLW) method is widely used to determine energy expenditure. In this work, we demonstrate the addition of the third stable isotope, 17O, to turn it into Triply Labelled Water (TLW), using the three isotopes measurement of optical spectrometry. We performed TLW (2H, 18O and17O) measurements for the analysis of the CO2 production (rCO2) of mice on different diets for the first time. Triply highly enriched water was injected into mice, and the isotope enrichments of the distilled blood samples of one initial and two finals were measured by an Off-Axis Integrated Cavity Output Spectroscopy instrument. We evaluated the impact of different calculation protocols and the values of evaporative water loss fraction. We found that the dilution space and turnover rates of 17O and 18O were equal for the same mice group, and that values of rCO2 calculated based on 18O-2H, or on 17O-2H agreed very well. This increases the reliability and redundancy of the measurements and it lowers the uncertainty in the calculated rCO2 to 3% when taking the average of two DLW methods. However, the TLW method overestimated the rCO2 compared to the indirect calorimetry measurements that we also performed, much more for the mice on a high-fat diet than for low-fat. We hypothesize an extra loss or exchange mechanism with a high fractionation for 2H to explain this difference.
Double Arterial Cannulation Versus Right Axillary Artery Cannulation for Acute Type A Aortic Dissection: a Retrospective Study
Authors: Zhang He , Xie Wei , Lu Yuzhou , Pan Tuo , Zhou Qing , Xue Yunxing , Wang Dongjin 
Published: August 2021

Abstract
Background: Cannulation strategy in surgery for acute type A aortic dissection (ATAAD) remains controversial. We aimed to retrospectively analyze the safety and efficacy of double arterial cannulation (DAC) compared with right axillary cannulation (RAC) for ATAAD.Methods: From January 2016 to December 2018, 431 ATAAD patients were enrolled in the study. Patients were divided into DAC group (n=341) and RAC group (n=90). Propensity score matching analysis was performed to compare the early and mid-term outcomes between these two groups. To confirm the organ protection effect by DAC, intraoperative blood gas results and cardiopulmonary bypass parameters were compared between the two groups.Results: Demographics and preoperative comorbidities were comparable between two groups, while patients in DAC group were younger than RAC group (51.55±13.21 vs. 56.07±12.16 years, P＜0.001 ) . DAC had a higher incidence of limb malperfusion (18.2% vs. 10.0%, P=0.063) and lower incidence of coronary malperfusion (5.3% vs. 12.2%, P=0.019). No significant difference in cardiopulmonary bypass and cross-clamp time was found between the two groups. The in-hospital mortality was 13.5% (58/431), while there was no difference between the two groups (13.5% vs. 13.3%; P=0.969). Patients who underwent DAC had higher incidence of postoperative stroke (5.9% vs. 0%, P=0.019) and lower incidence of postoperative acute kidney injury (AKI) (24.7% vs. 40.3%; P=0.015). During a mean follow-up period of 31.8 (interquartile range, 25-45) months, the overall survival was 81.5% for DAC group and 78.0% for RAC group (P=0.560). Intraoperative blood gas results and cardiopulmonary bypass parameters showed that DAC group had more intraoperative urine output volume than RAC group (P=0.05), and the time of cooling (P=0.04) and rewarming (P=0.04) were shorter in DAC group.Conclusions: DAC will not increase the surgical risks compared to RAC, but could reduce the incidence of postoperative AKI which may be benefit for renal protection.
Hospital-System Functionality Quantification Based on Supply–Demand Relationship Under Earthquake
Authors: Hou Zonghao , Zhang Juan , Zhang Mingyuan , Li Gang 
Published: August 2021

Abstract
The post-earthquake functionality of hospital systems seriously affects the recovery time of a city, and it is important to quantify the hospital system functionality. This paper presents a method that takes into consideration the post-earthquake medical supply–demand relationship in order to quantify the initial functionality and instantaneous functionality loss of a hospital system under the conditions of an earthquake, which is different from the current quantitative method that takes into consideration only the internal factors of the hospital system. In this method, a geographic information system and an earthquake damage prediction model are first used to obtain the medical supply capacity before and after the earthquake and the medical demand after the earthquake. Based on the results of the post-earthquake medical demand and the distribution of the medical supply capacity, the substitution capacity of medical resources is then calculated. Finally, the substitution capacity of medical resources is used to evaluate the functionality of the hospital system before and after the earthquake. A hospital system of a city in eastern China is considered as an illustrative example, and the impact of changes in the medical supply and demand at different times of the day on the hospital system functionality are analyzed. The results obtained show that the changes in medical supply and demand not only affect the hospital system functionality, but also cause changes in the instantaneous functionality loss of the hospital system after the earthquake. The proposed method can be used to quantify the hospital system functionality and reflect the balance of the medical supply–demand relationship before and after the earthquake, and it can help decision makers in developing a disaster reduction strategy to improve the disaster resilience of the hospital system.
Biomonitoring of Bromine-Containing Trihalomethanes in the Pregnant Women: Urinary Levels and Association with Lifestyle Factors
Authors: Dehdashti Bahare , Feizi Awat , Amin Mohammad Mehdi , Bagheri Nasrin , Daniali Seyede Shahrbanoo , Kelishadi Roya 
Published: August 2021

Abstract
Trihalomethanes containing bromine (Br-THMs) are compounds formed from the reaction of organic and inorganic substances in drinking water with chlorine as a common disinfectant. Epidemiological evidence indicated various outcomes as a result of long-term exposure to these compounds. This study aims to investigate the concentration of urinary Br-THMs in a sample of third-trimester pregnant women and to determine its correlation with lifestyle factors. This cross-sectional study was conducted among 118 pregnant women in Isfahan, Iran. The third-trimester urine Br-THMs including dibromochloromethane (DBCM), bromodichloromethane (BDCM), and broomcorn (TBM) were measured using solid-phase micro-extraction gas chromatography. The distribution of urinary Br-THMs concentration was positively skewed then these variables were subjected to logarithmic transformation. Spearman ranks correlation coefficient, and two independent samples t-test were used to assess the association of urinary Br-THMs concentration with its demographic and lifestyle determinants.The findings showed that the mean (SD) concentrations of DBCM, BDCM, TBM and brominatede THMs were 14.76 (27.17), 10.25 (11.37), 4.96 (3.21) and 30.17 (40.80) ng/L, respectively. In addition, significant inverse correlation was found between the use of water storage tanks and Br-THMs (DBCM, BDCM, TBM and brominatede THMs, P-value = 0.005, 0.019, >0.001 and 0.007 < 0.05, respectively).In this study, among the quantitative and qualitative variables, the use of storage tanks had an inverse correlation with Br-THMs. In addition, the status of urinary concentration of Br-THMs in pregnant women was less than in the other countries in the same area. Improving water quality and using modern methods to eliminate disinfection by-products as well as improving lifestyle patterns are efficient methods to reduce exposure to these contaminants.
Research on Constant Force Polishing Control of Aero-engine Blade Based on Expanded State Observer
Authors: Zhang Wenhua , Dai Shijie , Zhao Yufeng , Mu Jiaheng , Hu Tianrong , Li Pengwei , Deng Riqing , Yan Lei 
Published: August 2021

Abstract
This paper presents a parallel control method based on the expanded state observer (ESO) for aero-engine blade robot polishing. Aiming to reduce the fluctuation of polishing force caused by environmental noise and modeling errors. First, calibrate six-dimensional force sensor according to the maximum acceleration of the end effector during the polishing process. Then, build the gravity compensation and zero drift compensation model. Besides, use this model to compensate measurement error of the six-dimensional force sensor. Finally, calculate the error between the expected polishing force and the actual feedback value and its derivative value. Use calculation results to design the control boundary layer. The polishing force controller is divided into two parallel control loops to design. When the switching value is in the control boundary layer. A nonlinear active disturbance rejection control (ADRC) loop is used. When the switching value is outside the control boundary layer. An ESO-based sliding mode control (SMC) loop is used. Simulation and experimental results show that the proposed parallel control method based on ESO has a fast response and high robustness compared with FuzzyPID, PID, and ADRC. It can effectively suppress the force fluctuation in the polishing process and significantly improve the surface processing quality of the aero-engine blade.
Hepatic Lipid Accumulation Induced by a High-fat Diet Is Regulated by Nrf2 Through Multiple Pathways
Authors: Qiu sheng , Liang Zerong , Wu Qinan , Wang Miao , Yang Mengliu , Chen Chen , zheng Hong ting , Zhu Zhiming , Li Ling , Yang Gangyi 
Published: August 2021

Abstract
BackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is reportedly involved in hepatic lipid metabolism, but the results are contradictory and the underlying mechanism thus remains unclear. Herein we focused on elucidating the effects of Nrf2 on hepatic adipogenesis and on determining the possible underlying mechanism. We established a metabolic associated fatty liver disease (MAFLD) model in high fat diet (HFD) fed Nrf2 knockout (Nrf2 KO) mice; further, a cell model of lipid accumulation was established using mouse primary hepatocytes (MPHs) treated with free fatty acids (FAs). Using these models, we investigated the relationship between Nrf2 and autophagy and its role in the development of MAFLD.ResultsWe observed that Nrf2 expression levels were up-regulated in patients with MAFLD and diet-induced obese mice. Nrf2 deficiency led to hepatic lipid accumulation in vivo and in vitro, in addition to, promoting lipogenesis mainly by increasing SREBP-1 activity. Moreover, Nrf2 deficiency attenuated autophagic flux and inhibited the fusion of autophagosomes and lysosomes in vivo and in vitro. Weakened autophagy caused reduced lipolysis in the liver. Importantly, Chromatin immunoprecipitation-qPCR (ChIP-qPCR) and dual-luciferase assay results proved that Nrf2 bound to LAMP1 promoter and regulated its transcriptional activity. We accordingly report that Nrf2-LAMP1 interaction has an indispensable role in Nrf2-regulated hepatosteatosis. ConclusionsThese data collectively confirm that Nrf2 deficiency promotes hepatosteatosis by enhancing SREBP-1 activity and attenuating autophagy. To conclude, our data reveal a novel multi-pathway effect of Nrf2 on lipid metabolism in the liver, and we believe that multi-target intervention of Nrf2 signaling is a promising new strategy for the prevention and treatment of MAFLD.