bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal variation in the adult sex ratio, male aggregation, and movement of two tropical cloud forest dung beetles
Authors: Barretto Julliana , Baena Martha L , Domínguez Israel Huesca , Escobar Federico 
Published: December 2021

Abstract
While theory suggests that at conception the sex ratio should be balanced (1:1), this can be variable across space and time in wild populations. Currently, studies of the environmental factors that regulate adult sex ratio (ASR) in species with different life history traits are scarce. Using capture–recapture over a year, we analyzed the influence of habitat type (forest and nonforest) and season (rainy and dry) on variation in ASR, male aggregation and the trajectory movement of 2 dung beetle species with different life history traits: Deltochilum mexicanum (a hornless roller species) and Dichotomius satanas (a tunneler species with horns on its head and thorax). We found opposite tendencies. The D. mexicanum population tends to be female-biased, but the population of D. satanas tends to be predominantly male, and observed values were not related to habitat type or season. However, the 95% confidence intervals estimated were highly variable between seasons depending on habitat. On examining the monthly variation in ASR for both habitats, we found that it depends on the species. In addition, male aggregation differed between species depending on habitat type and season, and species movement patterns were closely related to their habitat preferences. Based on our results, we argue that comparative population studies of species with different life history traits are necessary to understand the variation in demographic parameters as well as its ecological and evolutionary implications in the face of spatial and climatic environmental variation.
Feasibility of remote technical support for electrophysiological ablation procedures during the current COVID-19 pandemic
Authors: Müssigbrodt Andreas , Demoniere Fabrice , Banydeen Rishika , Finoly Steeve , Mommarche Max , Inamo Jocelyn 
Published: December 2021

Abstract

Aims
The treatment of heart rhythm disorders has been significantly impacted by direct consequences of the current COVID-19 pandemic, as well as by restrictions aimed towards constraining viral spread.

Methods and results
Usually, catheter ablations of cardiac arrhythmias are guided by electro-anatomic mapping (EAM) systems. Technical staff with medical training, or medical staff with technical training, are needed to assist the operator. Travel restrictions due to the current COVID-19 pandemic have limited the in-person availability of technical support staff. To overcome these limitations, we explored the feasibility of a trans-atlantic remote technical support for EAM, with an internet-based communication platform, for complex electrophysiological ablation procedures.

Conclusion
Our first experience, based on nine ablation procedures of different arrhythmias, highlights the feasibility of this approach. Remote support for EAM might therefore facilitate continuous care for patients with arrhythmias during the COVID-19 pandemic, particularly in insular settings. Beyond COVID-19-related challenges, this approach will likely play a greater role in the cardiology field in years to come, due to its significant advantages.
Influence on kinesiophobia by disability, physical, and behavioural variables after a heart transplantation
Authors: Marques-Sule Elena , Söderlund Anne , Almenar Luis , Espí-López Gemma Victoria , López-Vilella Raquel , Bäck Maria 
Published: December 2021

Abstract

Background
From clinical experience, kinesiophobia represents a barrier to being physically active after a heart transplantation (HTx), but studies in this field are lacking. Identifying the factors associated with kinesiophobia is essential to determine preventive interventions to avoid negative consequences for health.

Aims
To study the influence of disability, physical, and behavioural variables on kinesiophobia in patients with an HTx.

Methods
A total of 117 patients with an HTx [51 women; mean age 56 (SD 12.1) years] were recruited at an outpatient clinic. These patients were asked to fill in questionnaires measuring kinesiophobia, self-reported physical activity (PA), exercise self-efficacy, motivation for PA, and disability. A multiple regression analysis was conducted to examine the statistical prediction of kinesiophobia as a dependent variable, with the questionnaires, gender and education as independent variables.

Results
The independent variables explained 70% of the variance in kinesiophobia. The prediction model was significant (F = 32.1, P &lt; 0.001). The time from transplantation (standardised coefficient, beta; −0.17), the total exercise self-efficacy (−0.16), extrinsic motivation (−0.23), and the disability total score (0.63) were significant predictors of kinesiophobia, while the independent variables of gender, education, intrinsic motivation, and the PA total score were not significant.

Conclusions
This study highlights that a short time from transplantation, low self-efficacy, low extrinsic motivation, and a high level of disability explained high levels of kinesiophobia in patients after an HTx. These results suggest that an increased awareness of the biopsychosocial health perspective is essential in order to maximising patient outcomes after an HTx.
Ankfn1-mutant vestibular defects require loss of both ancestral and derived paralogs for penetrance in zebrafish
Authors: Ross Kevin D , Ren Jie , Zhang Ruilin , Chi Neil C , Hamilton Bruce A 
Published: December 2021

Abstract
How and to what degree gene duplication events create regulatory innovation, redundancy, or neofunctionalization remain important questions in animal evolution and comparative genetics. Ankfn1 genes are single copy in most invertebrates, partially duplicated in jawed vertebrates, and only the derived copy retained in most mammals. Null mutations in the single mouse homolog have vestibular and neurological abnormalities. Null mutation of the single Drosophila homolog is typically lethal with severe sensorimotor deficits in rare survivors. The functions and potential redundancy of paralogs in species with two copies are not known. Here, we define a vestibular role for Ankfn1 homologs in zebrafish based on the simultaneous disruption of each locus. Zebrafish with both paralogs disrupted showed vestibular defects and early lethality from swim bladder inflation failure. One intact copy at either locus was sufficient to prevent major phenotypes. Our results show that vertebrate Ankfn1 genes are required for vestibular-related functions, with at least partial redundancy between ancestral and derived paralogs.
Integrating recreational fishing into harvest strategies: linking data with objectives
Authors: Fowler Ashley M , Ochwada-Doyle Faith A , Dowling Natalie A , Folpp Heath , Hughes Julian M , Lowry Michael B , Lyle Jeremy M , Lynch Tim P , Miles Nathan G , Chick Rowan C 
Published: December 2021

AbstractRecreational fishing (RF) is a popular pastime resulting in substantial fish mortality in many regions. Yet inclusion of RF in fishery harvest strategies is limited, because the sector's objectives are poorly understood, as are the data required to track their performance. To address this, we reviewed RF data sources available from a region of globally high participation (New South Wales [NSW], Australia) and evaluated their utility for RF-specific performance indicators within harvest strategies. We then linked these data sources to RF objectives they may be used to monitor. A total of 21 RF data sources were identified in NSW over the past two decades, spanning all major aquatic environments and 146 fished species. Numerous data sources were available to monitor ecological objectives, providing time-series and potential reference points for key indicators such as catch-per-unit-effort. Few data sources were available for social, economic, and institutional objectives, consistent with a global paucity of these data. We found that most social objectives of RF lie outside the scope of traditional harvest strategies, although some are linked to underlying ecological performance. Harvest strategy performance for RF will depend on the relative importance of social objectives and whether these can be achieved by controlling harvest.
Head Transplantation and Immortality: When Is Life Worth Living Forever?
Authors: Parker J Clint 
Published: December 2021

Abstract
Head transplantation fits within the broader conceptual space occupied by transhumanists and others who seek to extend the lives of human beings indefinitely. It is reasonable to reflect on whether, under what circumstances, and in what ways human immortality would be good. In this paper, I disambiguate the ways in which immortality might be considered a human good and then argue that immortality is neither necessary nor sufficient condition for objective meaning in life. I also argue that mortality is not a necessary condition for objective meaning in life.
Heads, Bodies, Brains, and Selves: Personal Identity and the Ethics of Whole-Body Transplantation
Authors: Iltis Ana 
Published: December 2021

AbstractPlans to attempt what has been called a head transplant, a body transplant, and a head-to-body transplant in human beings raise numerous ethical, social, and legal questions, including the circumstances, if any, under which it would be ethically permissible to attempt whole-body transplantation (WBT) in human beings, the possible effect of WBT on family relationships, and how families should shape WBT decisions. Our assessment of many of these questions depends partially on how we respond to sometimes centuries-old philosophical thought experiments about personal identity. As with so much in bioethics, it is impossible to escape, or at least inadvisable to try to bypass, the relevant foundational philosophical concerns.
A Dilemma for Respecting Autonomy: Bridge Technologies and the Hazards of Sequential Decision-Making
Authors: Kestigian Aidan , London Alex John 
Published: December 2021

AbstractRespect for patient autonomy can apply at two levels: ensuring that patient care reflects their considered values and wishes and honoring patient preferences about how to make momentous decisions. Caregivers who seek to respect patient autonomy in the context of some end-of-life decisions face a dilemma. Because these decisions are fraught, patients may prefer to approach them sequentially, only making decisions at the time they arise. However, respecting patients’ preferences for a sequential approach can increase the likelihood that surrogates and care teams wind up in situations in which they lack information needed to ensure patients receive care that conforms to their considered values after they are no longer competent to make decisions for themselves. Sequential decision-making can thus conflict with the goal of ensuring care reflects the wishes of patients. After illustrating how this dilemma can arise in the use of life-sustaining “bridge” technologies, we argue that care teams may be warranted in requiring patients to articulate their wishes in an advance care plan before treatment begins. In some cases, care teams may even be permitted to refuse to undertake certain courses of care, unless patients articulate their wishes in an advance care plan.
Dark matter haloes in the multicomponent model. III. From dwarfs to galaxy clusters
Authors: Todoroki Keita , Medvedev Mikhail V 
Published: December 2021

ABSTRACT
A possibility of DM being multicomponent has a strong implication on resolving decades-long known cosmological problems on small scale. In addition to elastic scattering, the model allows for inelastic interactions, which can be characterized by a ‘velocity kick’ parameter. The simplest 2cDM model with cross-section $0.01\lesssim \sigma /m\lt 1\, \textrm {cm}^{2}{ \rm g}^{-1}$ and the kick velocity $V_{\mathrm{ k}}\simeq 100\, \rm {km\, s}^{-1}$ have been shown to robustly resolve the missing satellites, core-cusp, and too-big-to-fail problems in N-body cosmological simulations tested on Milky Way (MW)-like haloes of a virial mass ${\sim}5 \times 10^{11}\, {\rm M_{\odot }}$ (Papers I & II). With the aim of further constraining the parameter space available for the 2cDM model, we extend our analysis to dwarf and galaxy cluster haloes with their virial mass of ∼107−108 and ${\sim}10^{13} - 10^{14}\, {\rm M_{\odot }}$, respectively. We find that σ0/m ≳ 0.1 cm2g−1 is preferentially disfavoured for both dwarfs and galaxy cluster haloes in comparison with observations, while σ0/m = 0.001 cm2g−1 causes little perceptible difference from that of the CDM counterpart for most of the cross-section’s velocity dependence studied in this work. Our main result is that within the reasonable set of parameters, the 2cDM model can successfully explain the observational trends seen in dwarf galaxy and galaxy cluster haloes, and the model leaves us an open window for other possible alternative DM models.
An Egalitarian Account of Composition and Realization
Authors: Piccinini Gualtiero 
Published: December 2021

Abstract
I argue that wholes are neither identical to nor (completely) distinct from their parts. Instead, wholes are invariants under some transformations in their parts. Similarly, higher-level properties are neither identical to nor (completely) distinct from their lower-level realizers. Instead, higher-level properties are aspects of their realizers that are invariant under some transformations in their realizers. Nowhere in this picture is there any ontological hierarchy between levels of composition or realization. Neither wholes nor their parts are more fundamental. Neither is prior. Neither reduces to the other. Neither is eliminated. Ditto for higher-level properties and their lower-level realizers. Instead, wholes and their properties as well as parts and their properties are different yet invariant aspects of reality. The result is an egalitarian account of composition and realization.
Societal targeting in researcher funding: An exploratory approach
Authors: Ramos-Vielba Irene , Thomas Duncan A , Aagaard Kaare 
Published: December 2021

AbstractShaping public research to enhance its societal contribution has become a key policy concern. Against this background, how research funding may stimulate the societal orientation of scientific research—or how funding is societally targeted—has been underexplored. This article proposes an exploratory approach to characterize societal targeting in individual researcher funding, based on four key societal targeting dimensions: interdisciplinarity, transdisciplinarity, prioritized research problems and user-oriented outputs. All these targeting dimensions of funding can potentially shape both researchers’ research networks and practices towards societal goals. These dimensions can be identified in context by studying ex ante specifications of funding instruments, i.e. rules and conditions for funding provision to researchers. We illustrate the dimensions in various degrees using two real cases of national public research funding. This systematic perspective on funding instrument characteristics then can potentially improve research evaluation, by allowing assessment in more detail of which funding dimensions associate with particular kinds of research ultimately being undertaken.
Dietary strategies for the prevention of asthma in children
Authors: Venter Carina , Smith Peter K. , Arshad Hasan 
Published: December 2021

Purpose of review
This review summarizes information relating to dietary intake during pregnancy, lactation and early life that may prevent childhood asthma. This review also summarizes how future studies may be improved.

Recent findings
Recent findings from observational studies suggest that eating according to certain dietary patterns during pregnancy, such as the dietary inflammatory index, Mediterranean diet and Maternal diet index, may reduce asthma and or wheeze in the child. Vitamin D supplementation with higher doses than recommended during pregnancy may be associated with reduced early transient childhood wheezing in the offspring. Higher levels of omega-3 fatty acids in breast milk may be protective against childhood asthma. Breastfeeding infants has been shown to offer many benefits to mother and child but a direct relationship between breastfeeding and the development of asthma has not been established. During childhood, infants and children may need to reduce their intake of advanced glycation end products, increase their food intake according to the traditional Mediterranean diet and increase the diversity of foods eaten.

Summary
Current evidence provides limited suggestions regarding dietary changes for preventing early transient childhood wheezing. In order to harmonize methods for future data collection and reporting, it is important to harmonize relevant definitions and other important factors. The aim of the considerations described here is to enable a better comparison of future studies and provide better guidance to patients and families.
Injecting Opioid Use Disorder Treatment in Jails and Prisons: The Potential of Extended-release Buprenorphine in the Carceral Setting
Authors: Berk Justin , del Pozo Brandon , Rich Josiah D. , Lee Joshua D. 
Published: December 2021

Abstract
As the opioid overdose cases rise, policy-makers and researchers should target interventions to populations at highest risk. Incarceration serves as a risk factor for opioid overdose (Gan et al. Addiction 2021) and a large portion of recent overdose deaths have had encounters in the criminal justice system.
Medications for opioid use disorder in the criminal justice system can save lives, though unique administrative barriers in jails and prisons hinder access. As facilities expand medications for opioid use disorder access (due to new legislation and court rulings across states), extended-release buprenorphine offers an opportunity to overcome these barriers including logistics of administration, diversion concern, patient stigma, and an increased bridge of treatment during re-entry to the community.
As extended-release buprenorphine has practical advantages in correctional health delivery, future research and policy discussions should investigate its optimal role in treating opiate addiction in a carceral setting.
Oxazepam Detected in Urine 79 Days After Withdrawal of Diazepam: A Case Report
Authors: Serkland Trond Trœtteberg , Dale Gro Helen , Kaldestad Ingeborg Caroline , Berg Jon Andsnes , Methlie Camilla Borthen 
Published: December 2021

Abstract
Patients suffering from substance use disorder, including for instance benzodiazepines, may have comorbidity with attention deficit hyperactivity disorder (ADHD). Centrally acting stimulants play an important role in the treatment of ADHD. Before such treatment can be initiated, withdrawal of benzodiazepines may be necessary. Urine testing is the preferred method for monitoring adherence in benzodiazepine withdrawal, but there is a lack of studies reporting detection time. Here, we report a case of a 30-year-old woman with substance use disorder and ADHD who had detectable metabolites of diazepam 79 days after withdrawal. To our knowledge, no cases with detection time equivalent to this have previously been published. This case report serves as an example that clinicians may need to consider interindividual pharmacokinetic characteristics when interpreting the results of urine drug tests, and that a positive urine test may still be consistent with abstinence from a certain drug. In the current case, a high body mass index and a genetic polymorphism gave a reasonable explanation for the prolonged detection of diazepam metabolites.
Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach
Authors: Cohen Shawn M. , Weimer Melissa B. , Levander Ximena A. , Peckham Alyssa M. , Tetrault Jeanette M. , Morford Kenneth L. 
Published: December 2021

Abstract
Low dose buprenorphine initiation, is an alternative method of initiating buprenorphine in which the starting dose is very low and gradually increased to therapeutic levels over a period of days. This method takes advantage of slow displacement of the full opioid agonist from mu-opioid receptors, avoiding the need for a person with opioid use disorder to experience opioid withdrawal symptoms before initiating buprenorphine, while also minimizing the risk of precipitated opioid withdrawal. With this initiation method, full opioid agonists can be continued as buprenorphine is initiated, expanding the population to which buprenorphine can be offered. To date, the literature on low dose initiation is primarily case-based but rapidly growing. While evidence emerges, guidance for the use of low dose initiation is clearly desired and urgently needed in the context of an increasingly risky and contaminated opioid drug supply, particularly with high potency synthetic opioids, driving overdose deaths. Despite limited evidence, several principles to guide low dose initiation have been identified including: (1) choosing the appropriate clinical situation, (2) initiating at a low buprenorphine dose, (3) titrating the buprenorphine dose gradually, (4) continuing the full opioid agonist even if it is nonmedical, (5) communicating clearly with frequent monitoring, (6) pausing or delaying buprenorphine dose changes if opioid withdrawal symptoms occur, and (7) prioritizing care coordination. We review a practical approach to low dose initiation in hospital-based and outpatient settings guided by the current evidence.
Low Dose Buprenorphine Induction With Full Agonist Overlap in Hospitalized Patients With Opioid Use Disorder: A Retrospective Cohort Study
Authors: Bhatraju Elenore P. , Klein Jared W. , Hall Allana N. , Chen David R. , Iles-Shih Matthew , Tsui Judith I. , Merrill Joseph O. 
Published: December 2021

Objective
To describe the outcomes of buprenorphine/naloxone low dose induction with overlap of full opioid agonists among hospitalized patients with opioid use disorder (OUD) as an alternative to standard induction strategies.

Methods
Retrospective cohort study of patients with OUD who were admitted to the hospital over a 1-year period and initiated ono buprenorphine using initial doses of 0.5 mg and gradually increased while the patient remained on full agonists. Descriptive variables included basic demographics, reason for switching to buprenorphine, baseline opioid and morphine equivalent dose. The primary outcome was a successful transition defined by the patient leaving the hospital with a buprenorphine prescription. Bivariate analysis identified factors associated with unsuccessful medication transitions. Secondary outcomes included reported withdrawal symptoms and 30 day follow up to an outpatient buprenorphine program.

Results
Sixty two patients underwent low dose with overlap induction during the study period. Fourteen patients were on methadone for OUD before hospital admission. Fifty one patients (82%) successfully left the hospital with a prescription for buprenorphine. Factors associated with lower likelihood of success included older age, transitioning due to discharge placement needs and presence of withdrawal symptoms during the transition. Overall, 66% (N = 23) of patients referred within the same health care system followed up within 30 days.

Conclusions
Low dose inductions with overlap of full opioid agonists were largely successful in transitioning hospitalized patients from full agonist opioids to buprenorphine. However, there were several factors associated with lower likelihood of success. Future work could focus on treatment of withdrawal symptoms and system-level changes ensuring patient-centered medication decisions.