bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inequity in uptake of hospital-based childbirth care in rural Tanzania: analysis of the 2015–16 Tanzania Demographic and Health Survey
Authors: Straneo Manuela , Benova Lenka , Hanson Claudia , Fogliati Piera , Pembe Andrea B , Smekens Tom , van den Akker Thomas 
Published: June 2021

Abstract
Proportions of facility births are increasing throughout sub-Saharan Africa, but obstetric services vary within the health system. In Tanzania, advanced management of childbirth complications (comprehensive emergency obstetric care) is offered in hospitals, while in frontline, primary health care (PHC) facilities (health centres and dispensaries) mostly only routine childbirth care is available. With over half (54%) of rural births in facilities, we hypothesized the presence of socio-economic inequity in hospital-based childbirth uptake in rural Tanzania and explored whether this relationship was modified by parity. This inequity may compound the burden of greater mortality among the poorest women and their babies. Records for 4456 rural women from the 2015–16 Tanzania Demographic and Health Survey with a live birth in the preceding 5 years were examined. Proportions of births at each location (home/PHC/hospital) were calculated by demographic and obstetric characteristics. Multinomial logistic regression was used to obtain crude and adjusted odds ratios of home/PHC and hospital/PHC births based on household wealth, including interaction between wealth and parity. Post-estimation margins analysis was applied to estimate childbirth location by wealth and parity. Hospital-based childbirth uptake was inequitable. The gap between poorest and richest was less pronounced at first birth. Hospital-based care utilization was lowest (around 10%) among the poorest multiparous women, with no increase at high parity (≥5) despite higher risk. PHC-based childbirth care was used by a consistent proportion of women after the first birth (range 30–51%). The poorest women utilized it at intermediate parity, but at parity ≥5 mostly gave birth at home. In an effort to provide effective childbirth care to all women, context-specific strategies are required to improve hospital-based care use, and poor, rural, high parity women are a particularly vulnerable group that requires specific attention. Improving childbirth care in PHC and strengthening referral linkages would benefit a considerable proportion of women.
The Evil May Day riot of 1517 and the popular politics of anti-immigrant hostility in early modern London
Authors: Waddell Brodie 
Published: June 2021

Abstract
London experienced repeated outbreaks of popular xenophobia in the sixteenth and seventeenth centuries, with the worst coming in the Evil May Day riot of 1517. This article illuminates the hydra-like nature of the stereotype of the immigrant at this time, which rhetorically combined the diverse population of aliens into a single material and political threat. It begins with a close analysis of the riot itself, before examining the continuing relevance of this distinctive caricature. It shows how the perceived ‘privileges’ afforded to several different sorts of strangers in early modern London made them a special target for popular hostility.
Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease
Authors: Cachón-González María B , Wang Susan , Cox Timothy M 
Published: June 2021

Abstract
Krabbe disease, an inherited leukodystrophy, is a sphingolipidosis caused by deficiency of β-galactocerebrosidase: it is characterized by myelin loss, and pathological activation of macrophage/microglia and astrocytes. To define driving pathogenic factors, we explored the expression repertoire of candidate neuroinflammatory genes: upregulation of receptor interacting protein kinase 1 (Ripk1) and disease-associated microglia (DAM) genes, including Cst7 and Ch25h, correlated with severity of Krabbe disease genetically modelled in the twitcher mouse. Upregulation of Ripk1 in Iba1/Mac2-positive microglia/macrophage associated with the pathognomic hypertrophic/globoid phenotype of this disease. Widespread accumulation of ubiquitinin1 in white and grey matter co-localised with p62. In Sandhoff disease, another sphingolipid disorder, neuroinflammation, accumulation of p62 and increased Ripk1 expression was observed. The upregulated DAM genes and macrophage/microglia expression of Ripk1 in the authentic model of Krabbe disease strongly resemble those reported in Alzheimer disease associating with disturbed autophagosomal/lysosomal homeostasis. Activation of this shared molecular repertoire, suggests the potential for therapeutic interdiction at a common activation step, irrespective of proximal causation. To clarify the role of Ripk1 in the pathogenesis of Krabbe disease, we first explored the contribution of its kinase function, by intercrossing twitcher and the K45A kinase-dead Ripk1 mouse and breeding to homozygosity. Genetic ablation of Ripk1 kinase activity neither altered the neuropathological features nor the survival of twitcher mice. We conclude that Ripk1 kinase-dependent inflammatory and degenerative capabilities play no instrumental role in Krabbe disease; however, putative kinase-independent functions of Ripk1 remain formally to be explored in its molecular pathogenesis.
Prevalence and Clinical Significance of Occult Hepatitis B Infection in The Gambia, West Africa
Authors: Ndow Gibril , Cessay Amie , Cohen Damien , Shimakawa Yusuke , Gore Mindy L , Tamba Saydiba , Ghosh Sumantra , Sanneh Bakary , Baldeh Ignatius , Njie Ramou , D’Alessandro Umberto , Mendy Maimuna , Thursz Mark , Chemin Isabelle , Lemoine Maud 
Published: June 2021

Abstract

Background
Prevalence and clinical outcomes of occult hepatitis B infection (OBI) have been poorly studied in Africa.

Methods
Using the PROLIFICA cohort, we compared the prevalence of OBI between hepatitis B surface antigen (HBsAg)-negative healthy adults screened from the general population (controls) and HBsAg-negative patients with advanced liver disease (cases), and estimated the population attributable fraction for the effect of OBI on advanced liver disease.

Results
OBI prevalence was significantly higher among cases (15/82, 18.3%) than controls (31/330, 9.4%, P = .03). After adjusting for age, sex, and anti-hepatitis C virus (HCV) serology, OBI was significantly associated with advanced liver disease (odds ratio, 2.8; 95% confidence interval [CI], 1.3–6.0; P = .006). In HBsAg-negative people, the proportions of advanced liver disease cases attributable to OBI and HCV were estimated at 12.9% (95% CI, 7.5%–18.1%) and 16.9% (95% CI, 15.2%–18.6%), respectively.

Conclusions
OBI is endemic and an independent risk factor for advanced liver disease in The Gambia, West Africa. This implies that HBsAg-negative people with liver disease should be systematically screened for OBI. Moreover, the impact of infant hepatitis B immunization to prevent end-stage liver disease might be higher than previous estimates based solely on HBsAg positivity.
Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post–COVID-19 Convalescent Samples
Authors: Shrwani Khalid , Sharma Ravi , Krishnan Madhan , Jones Terry , Mayora-Neto Martin , Cantoni Diego , Temperton Nigel J , Dobson Susan L , Subramaniam Krishanthi , McNamara Paul S , Cunliffe Nigel A , Turtle Lance , Zhang Qibo 
Published: June 2021

Abstract

Background
A notable feature of coronavirus disease 2019 (COVID-19) is that children are less susceptible to severe disease. Children are known to experience more infections with endemic human coronaviruses (HCoVs) compared to adults. Little is known whether HCoV infections lead to cross-reactive anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies.

Methods
We investigated the presence of cross-reactive anti–SARS-CoV-2 IgG antibodies to spike 1 (S1), S1-receptor-binding domain (S1-RBD), and nucleocapsid protein (NP) by enzyme-linked immunosorbent assays, and neutralizing activity by a SARS-CoV-2 pseudotyped virus neutralization assay, in prepandemic sera collected from children (n = 50) and adults (n = 45), and compared with serum samples from convalescent COVID-19 patients (n = 16).

Results
A significant proportion of children (up to 40%) had detectable cross-reactive antibodies to SARS-CoV-2 S1, S1-RBD, and NP antigens, and the anti-S1 and anti–S1-RBD antibody levels correlated with anti–HCoV-HKU1 and anti–HCoV-OC43 S1 antibody titers in prepandemic samples (P &lt; .001). There were marked increases of anti–HCoV-HKU1 and - OC43 S1 (but not anti-NL63 and -229E S1-RBD) antibody titers in serum samples from convalescent COVID-19 patients (P &lt; .001), indicating an activation of cross-reactive immunological memory to β-coronavirus spike.

Conclusions
We demonstrated cross-reactive anti–SARS-CoV-2 antibodies in prepandemic serum samples from children and young adults. Promoting this cross-reactive immunity and memory response derived from common HCoV may be an effective strategy against SARS-COV-2 and future novel coronaviruses.
Field Assessment of Aphid Doubling Time and Yield of Sorghum Susceptible and Partially Resistant to Sugarcane Aphid (Hemiptera: Aphididae)
Authors: Gordy John W , Seiter Nicholas J , Kerns David L , Reay-Jones Francis P F , Bowling Robert D , Way M O , Brewer Michael J 
Published: June 2021

AbstractSince outbreaks were first detected in grain sorghum, Sorghum bicolor (L.) Moench (Cyperales: Poaceae), in 2013, sugarcane aphid, Melanaphis sacchari Zehntner has become a major annual pest in grain sorghum-producing regions of North America. Economic thresholds have been recommended for susceptible hybrids, but these recommendations may not be suitable for grain sorghum hybrids partially resistant to sugarcane aphid. The objectives were to evaluate the grain yield-aphid density relationship and field-based population growth rates of the aphid on sorghum hybrids susceptible and partially resistant to sugarcane aphid across multiple years, locations, and hybrids. These data verified previously established economic injury levels for susceptible hybrids. The observed maximum aphid density ranged from 6 to 451 aphids per leaf for resistant hybrids and from 67 to 1,025 for susceptible hybrids. Across 50 location-year combinations, the maximum aphid density observed on resistant hybrids decreased by 0–99%, compared to a susceptible hybrid at the same location (mean reduction = 80%). Doubling time for sugarcane aphid populations on partially resistant hybrids was up to 6.4-fold higher than on known susceptible hybrids. For 48 of the 50 location-years, yield loss attributable to sugarcane aphid was not detected on the partially resistant hybrids; therefore, an economic injury level was unable to be estimated. If an economic injury level exists for resistant hybrids, it is likely at an aphid population level that exceeds the levels experienced in this study. It remains prudent to monitor resistant hybrids for unusual leaf decay associated with aphid densities that exceed current economic injury levels used for susceptible hybrids.
Sex differences in the prevalence of radiographic findings of structural hip deformities in patients with symptomatic femoroacetabular impingement
Authors: Zhou Jun , Melugin Heath P , Hale Rena F , Song Bryant M , Okoroha Kelechi R , Levy Bruce A , Krych Aaron J 
Published: June 2021

ABSTRACTThe purpose of this study was to determine the sex differences in the overall prevalence of radiographic femoroacetabular impingement (FAI) deformity patients presenting with hip pain and to identify the most common radiographic findings in male and female patients. A geographic database was used to identify patients between the age of 14 and 50 years with hip pain from 2000 to 2016. A chart and radiographic review was performed to identify patients with cam, pincer and mixed-type FAI. A total of 374 (449 hips) out of 612 (695 hips) male patients and 771 (922 hips) out of 1281 (1447 hips) female patients had radiographic features consistent with FAI. Ninety-four male hips (20.9%) and 45 female hips (4.9%) had cam type, 20 male hips (4.5%) and 225 female hips (24.4%) had pincer type and 335 male hips (74.6%) and 652 female hips (70.7%) had mixed type. The overall prevalence of radiographic findings consistent with FAI in male and female patients with hip pain was 61.1% and 60.2%, respectively. Mixed type was the most prevalent. The most common radiographic finding for cam-type FAI was an alpha angle &gt;55°, and the most common radiographic finding for pincer-type FAI was a crossover sign. Male patients were found to have a higher prevalence of cam-type deformities, whereas female patients were found to have a higher prevalence of pincer-type deformities.
Fatal attraction: intestinal amebiasis and COVID-19 as risk factors for colonic perforation
Authors: Dorantes Jorge Alberto , López-Becerril Jose Octavio , Zavala-Cerna Maria G 
Published: June 2021

Abstract
The parasite Entamoeba histolytica, the causal agent of amebiasis, is considered a worldwide emergent disease and still represents an important cause of death in Mexico. Here, we describe a clinical case, involving an inflammatory response to both Coronavirus Infectious Disease 2019 (COVID-19) and intestinal amebiasis 54-year-old, COVID-positive Mexican gentleman was admitted to surgery following 6 days of hematochezia. An exploratory laparotomy and colonoscopy revealed multiple fibrous and amebic ulcerations (5–10 cm in diameter), with necrotic tissue predominantly localized in the sigmoid, descending and ascending colon. We discuss the pathophysiological interplay of both COVID-19 and intestinal amebiasis with the aim of highlighting a potentially novel aggravating mechanism in surgical patients suffering from colonic perforation in the setting of abdominal sepsis.
A Comparative Study of Imputation Methods for Multivariate Ordinal Data
Authors: Wongkamthong Chayut , Akande Olanrewaju 
Published: June 2021

Abstract
Missing data remains a very common problem in large datasets, including survey and census data containing many ordinal responses, such as political polls and opinion surveys. Multiple imputation (MI) is usually the go-to approach for analyzing such incomplete datasets, and there are indeed several implementations of MI, including methods using generalized linear models, tree-based models, and Bayesian non-parametric models. However, there is limited research on the statistical performance of these methods for multivariate ordinal data. In this article, we perform an empirical evaluation of several MI methods, including MI by chained equations (MICE) using multinomial logistic regression models, MICE using proportional odds logistic regression models, MICE using classification and regression trees, MICE using random forest, MI using Dirichlet process (DP) mixtures of products of multinomial distributions, and MI using DP mixtures of multivariate normal distributions. We evaluate the methods using simulation studies based on ordinal variables selected from the 2018 American Community Survey. Under our simulation settings, the results suggest that MI using proportional odds logistic regression models, classification and regression trees, and DP mixtures of multinomial distributions generally outperform the other methods. In certain settings, MI using multinomial logistic regression models is able to achieve comparable performance, depending on the missing data mechanism and amount of missing data.
The Uchuu simulations: Data Release 1 and dark matter halo concentrations
Authors: Ishiyama Tomoaki , Prada Francisco , Klypin Anatoly A , Sinha Manodeep , Metcalf R Benton , Jullo Eric , Altieri Bruno , Cora Sofía A , Croton Darren , de la Torre Sylvain , Millán-Calero David E , Oogi Taira , Ruedas José , Vega-Martínez Cristian A 
Published: June 2021

ABSTRACT
We introduce the Uchuu suite of large high-resolution cosmological N-body simulations. The largest simulation, named Uchuu, consists of 2.1 trillion (12 8003) dark matter particles in a box of side-length 2.0 $\, h^{-1} \, \rm Gpc$, with particle mass of 3.27 × 108$\, h^{-1}\, \rm M_{\odot }$. The highest resolution simulation, Shin-Uchuu, consists of 262 billion (64003) particles in a box of side-length 140 $\, h^{-1} \, \rm Mpc$, with particle mass of 8.97 × 105$\, h^{-1}\, \rm M_{\odot }$. Combining these simulations, we can follow the evolution of dark matter haloes and subhaloes spanning those hosting dwarf galaxies to massive galaxy clusters across an unprecedented volume. In this first paper, we present basic statistics, dark matter power spectra, and the halo and subhalo mass functions, which demonstrate the wide dynamic range and superb statistics of the Uchuu suite. From an analysis of the evolution of the power spectra, we conclude that our simulations remain accurate from the baryon acoustic oscillation scale down to the very small. We also provide parameters of a mass–concentration model, which describes the evolution of halo concentration and reproduces our simulation data to within 5 per cent for haloes with masses spanning nearly eight orders of magnitude at redshift 0 ≤ z ≤ 14. There is an upturn in the mass–concentration relation for the population of all haloes and of relaxed haloes at z ≳ 0.5, whereas no upturn is detected at z &lt; 0.5. We make publicly available various N-body products as part of Uchuu Data Release 1 on the Skies & Universes site.1 Future releases will include gravitational lensing maps and mock galaxy, X-ray cluster, and active galactic nucleus catalogues.
On the formation of deuterated methyl formate in hot corinos
Authors: Awad Zainab , Coutens Audrey , Viti Serena , Holdship Jonathan 
Published: June 2021

ABSTRACT
Methyl formate, HCOOCH3, and many of its isotopologues have been detected in astrophysical regions with considerable abundances. However, the recipe for the formation of this molecule and its isotopologues is not yet known. In this work, we attempt to investigate, theoretically, the successful recipe for the formation of interstellar HCOOCH3 and its deuterated isotopologues. We used the gas–grain chemical model, uclchem, to examine the possible routes of formation of methyl formate on grain surfaces and in the gas-phase in low-mass star-forming regions. Our models show that radical–radical association on grains are necessary to explain the observed abundance of DCOOCH3 in the protostar IRAS 16293–2422. H-D substitution reactions on grains significantly enhance the abundances of HCOOCHD2, DCOOCHD2, and HCOOCD3. The observed abundance of HCOOCHD2 in IRAS 16293–2422 can only be reproduced if H-D substitution reactions are taken into account. However, HCOOCH2D remain underestimated in all of our models. The deuteration of methyl formate appears to be more complex than initially thought. Additional studies, both experimentally and theoretically, are needed for a better understanding of the interstellar formation of these species.
Feminist Philosophy of Mind
Authors: McWeeny Jennifer 
Published: June 2021

AbstractA feminist approach to philosophy of mind asks whether mind is gendered, raced, classed, and so on, and whether differences of gender, race, class, and other social categories are a matter of mind. This chapter outlines the scope, content, and aims of this emerging field with reference to three decisive moments in its evolution. First, the correspondence between Princess Elisabeth and Descartes is examined, with particular emphasis on Descartes’s claim that those who do not have the habit of philosophizing will be more apt to perceive the union of mind and body than their separation. Second, the chapter investigates Simone de Beauvoir’s contention that woman’s consciousness in a sexist society is a doubled or divided consciousness. Third, the chapter turns to Naomi Scheman’s criticism of the view that beliefs, desires, and emotions are individuated, identifiable states. Taken together, these arguments challenge the assumptions that minds are ahistorical, universal, and nonrelational and suggest instead that minds are is affected in substantive ways by oppression.
Philosophy of Science Analytic Feminist Approaches
Authors: Rolin Kristina 
Published: June 2021

Abstract
Feminist philosophy of science in the analytic tradition converges towards feminist empiricism that comes in three types: critical contextual empiricism, radical empiricism, and standpoint empiricism. Each type of feminist empiricism provides important resources for feminist philosophers of science especially when they seek to solve the bias paradox. The bias paradox arises when one aims to criticize some biases as epistemically harmful while at the same time acknowledge that some other biases are epistemically beneficial. The challenge is to understand how pernicious bias can be distinguished from an innocuous one. Critical contextual empiricism aims to solve the bias paradox by introducing epistemic norms for scientific communities and radical empiricism by subjecting biases to empirical testing. Standpoint empiricism emphasizes the importance of generating new evidence by empowering disadvantaged social groups. While feminist philosophers of science have abandoned the ideal of value-free science, they have not given up the concept of objectivity. Objectivity of scientific knowledge comes in degrees and depends on how well scientific communities facilitate criticism and succeed in eliminating pernicious bias.
Continental Feminist Approaches to Philosophy of Science
Authors: Olkowski Dorothea 
Published: June 2021

AbstractThis chapter offers an account of central issues and themes in continental feminist philosophical engagements with philosophy of science, reflection on examples of important contributions to this discussion, and a discussion of to what extent recent continental feminist work on the topic of science has contributed to the beginning of a new field in continental feminist philosophy of science. The chapter considers current work primarily concerned with physics and calls for future work focused on other scientific fields.
Feminism in Ancient Philosophy
Authors: Schultz Anne-Marie 
Published: June 2021

Abstract
This chapter offers an account of central issues and themes in feminist philosophical engagements with ancient Greek philosophy. It starts with an overview of the history of feminist engagements with Greek philosophers. The chapter then explores the role of women in the Pythagorean tradition, Plato’s complex treatment of women in the dialogues, Aristotle’s view of the feminine, and the role of women in later Greek philosophical traditions and ends with suggestions about the grounds for further research. Throughout the chapter, there are reflections on examples of important contributions to this scholarship. The chapter also contains discussion of the extent to which feminist work has changed or entered the mainstream of the field. It posits that ancient philosophy offers a resource for understanding the place of women in philosophy and gender discrimination in philosophy and in society.
Feminist Social and Political Philosophy
Authors: Bar On Bat-Ami 
Published: June 2021

Abstract
This chapter offers an account of central issues in feminist social and political philosophy, examples of important contributions and disagreements within the field, and suggestions regarding future directions in feminist social and political philosophy. The chapter reviews the relationship between feminist social and political philosophy and nonfeminist social and political philosophy and proposes a thematic taxonomy for the field that demarcate four subareas within it: (i) social ontology, (ii) norms, structures and power, (iii) social justice, (iv) politics. While necessarily crisscrossing each other, every one of the subareas is organized around different enough questions and therefore shifts the theoretical perspectives that are developed through their discussion.