bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk-Informed Benefit–Cost Analysis for Homeland Security R&D: Methodology and an Application to Evaluating the Advanced Personal Protection System for Wildland Firefighters
Authors: Thrift Stephanie Michelle , von Winterfeldt Detlof 
Published: February 2021

AbstractThis article describes a methodology for a risk-informed benefit–cost analysis that includes (i) risk analysis to quantify risk reduction benefits and (ii) uncertainty analyses to quantify probability distributions over costs and benefits. It also summarizes the lessons from 25 applications of this methodology to evaluate R&D projects of the Science and Technology Directorate of the Department of Homeland Security. The article then illustrates the methodology with a specific application to evaluate the benefits and costs of the Advanced Personal Protection System (APPS), a new garment system developed to protect wildland firefighters. The goals of the APPS project were to reduce risk and to improve comfort. The cost analysis revealed that the APPS garments are more expensive by about $279 per garment system. Total costs were roughly $7.3 million, including the upfront project cost and the increased 5 year cost of purchasing the APPS. Benefits from reduced injuries and fatalities resulted in 5 year benefits of about $19.3 million, with an NPV of $13.6 million in 2019 dollars. In the base case, the benefit–cost ratio was 2.87 and the return on investment was 187 % over 5 years. Taking the perspective of a decision-maker when the project was first funded in 2011, NPVs are $11,993,728, $10,025,519, and $7,967,479 in 2011 dollars for discount rates of 0, 3, and 7 % respectively. An uncertainty analysis of the NPV showed a large variability, ranging from the 5th percentile of $6.4 million to a median of $19.3 million to the 95th percentile of $43.7 million in 2019 dollars. This large range was primarily due to the uncertainty about the reduction of fatality and injury risks and the market penetration rates of the new garments.
Reasoning from the Uterus: Casanova, Women's Agency, and the Philosophy of Birth
Authors: Villarmea Stella 
Published: February 2021

AbstractThe emerging area of philosophy of birth is invaluable, first, to diagnose fallacious assumptions about the relation between the womb and reason, and, ultimately, to challenge potentially damaging narratives with major impact on birth care. With its analysis of eighteenth-century epistemic and medical discussions about the role of the uterus in women's reasoning (or lack of reasoning), this article supports two arguments: first, that women's “flawed thinking” was a premise drawn by many modern intellectual men, one that was presented as based upon empirical evidence; and second, that the pervasive construction of the uterus as an element that renders women wild, uncontrollable, and irrational continues to influence contemporary obstetrics (and maybe even to nurture obstetric violence), even as today's medicine and science consider themselves to be free of any such prejudices.This article shows the role that Giacomo Casanova played in debunking these prejudices and presents his short manuscript on the issue as an important contribution to the literature of the Enlightenment, with its argument against women's supposed “natural” inferiority and for the idea that differences in education (rather than anatomical differences) were to blame for women's subordinate position in society.Detailed analysis of the “thinking uterus” debate illuminates the different ways in which various arguments from/by the “anti-uterine” lobby were used to justify the subordination of women: sometimes emphasizing the connection between the uterus and thought and sometimes negating it, but always concluding that women's inferiority is to be found in some known or yet-to-be-discovered anatomical, and mainly sexual, deficiency or problem.
Girl Talk: Understanding Negative Reactions to Female Vocal Fry
Authors: Chao Monika , Bursten Julia R. S. 
Published: February 2021

AbstractVocal fry is a phonation, or voicing, in which an individual drops their voice below its natural register and consequently emits a low, growly, creaky tone of voice. Media outlets have widely acknowledged it as a generational vocal style characteristic of millennial women. Critics of vocal fry often claim that it is an exclusively female vocal pattern, and some say that the voicing is so distracting that they cannot understand what is being said under the phonation. Claiming that a phonation is so distracting as to prevent uptake of the semantic content of an utterance associated with it is an extreme reaction, especially when accompanied by demands for women to change their phonation. We argue that this reaction limits women's communicative autonomy. We analyze the extreme reaction to female vocal fry, which we characterize as a non-content-based response, from the perspectives of philosophy of language, feminist epistemology, and linguistics. We argue that when fry is heard as annoying and distracting, it is because the hearer interprets the speaker as echoing an utterance from a position of authority to which she is not entitled. We show that this reaction encodes conscious or unconscious sexist attitudes toward women's voices.
Psychometric properties of the Spanish version of the Fear of COVID-19 scale in Paraguayan population
Authors: Barrios I. , Ríos-González C. , O’Higgins M. , González-Urbieta I. , García O. , Almirón-Santacruz J. , Navarro R. , Melgarejo O. , Ruiz Díaz N. , Castaldelli-Maia J. M. , Ventriglio A. , Torales J. 
Published: February 2021

AbstractObjective:The aim of this study is to test the psychometric properties of the Spanish validation of the Fear of COVID-19 Scale (FCV-19S) in a Paraguayan population.Methods:Participants were recruited through an Internet-based survey. All participants whose scores in the Hospital Anxiety and Depression Scale (HADS) and The Fear Questionnaire (FQ) were greater than zero were included. 1245 subjects responded voluntarily: 1077 subjects, scoring >0, were considered.Results:To establish construct validity of the FCV-19S, an exploratory factor analysis was performed using the KMO test, which was adequate, and the Bartlett sphericity test, which was significant (p <.0001). The CFI, NFI, GFI, TLI and RMSEA indices were used to evaluate the model and showed good adjustment. Cronbach’s α showed valid internal consistency (α = 0.86). This validation was supported by significant correlation (p <.001) with the HADS scale for anxiety and depression and with the FQ scale for specific phobia.Conclusions:The Spanish version of the FCV-19S is a 7-item scale with two dimensions, psychological symptoms and physiological symptoms, which demonstrated robust psychometric properties in a Paraguayan population.
DE-THAKSINIZING THAILAND: THE LIMITS OF INSTITUTIONAL DESIGN
Authors: Caraway Teri L. 
Published: February 2021

AbstractAlmost two decades after the initial victory of Thai Rak Thai, scholars still debate the forces behind Thaksin's rise to power. I revisit these debates and argue for a more explicit analysis of dynamics over time. I distinguish analytically between the founding moment of TRT's first victory and the subsequent reproduction of its dominance. I argue that TRT's financial muscle was a sufficient condition for its 2001 victory, that institutions merely contributed to the scale of its victory, and that its platform was not decisive. Once in power, however, institutions were instrumental in allowing TRT to complete its term, but more important for its long-term dominance was the rapid implementation of its campaign promises, which created a mass constituency that in turn made Thaksin-linked parties resilient at the polls despite institutional reforms designed to weaken their electoral performance.
Aleutian Low variability for the last 7500 years and its relation to the Westerly Jet
Authors: Nagashima Kana , Addison Jason , Irino Tomohisa , Omori Takayuki , Yoshimura Kei , Harada Naomi 
Published: February 2021

AbstractThe Aleutian Low (AL) is one of the major atmospheric systems that determines environmental conditions during winter in the North Pacific Ocean, with impacts that affect the climates of both Asia and North America from mid- to high latitudes. However, the multi-centennial and longer scale behavior of the AL during the Holocene is not fully understood. In this study, AL variability since 7.5 ka was examined by applying the principal component analysis technique to published δ18O data derived from sedimentary calcite, peat, ice, and speleothem from western North America. The extracted Principal Component 1 (PC1) represents a dramatic change from the mid- to late Holocene, and appears to reflect long-term intensified AL related to interactions between orbitally-driven southward shift of the Westerly Jet (WJ) over East Asia and the northwestern Pacific, and intensification of the El Niño–Southern Oscillation. In contrast, PC2 is characterized by multi-centennial to millennial-scale oscillations, with a spatial loading pattern that suggests PC2 reflects AL intensity and position shifts. These oscillations are contemporaneous with both WJ latitude and/or the meandering path shifts over East Asia and solar activity change, suggesting that a decrease/increase in solar irradiance is related to AL variability via interactions with the WJ.
Changes in adiposity and fat tissue distribution among preschool children from Kraków, Poland, from 2008 to 2018
Authors: Żegleń Magdalena , Kryst Łukasz , Kowal Małgorzata , Sobiecki Jan , Woronkowicz Agnieszka 
Published: February 2021

AbstractIn the light of changes in the living conditions of populations, excess adiposity is currently a serious public health problem worldwide. The aim of this study was to assess the changes in the body fat ratio among preschool children aged 3–7 years from Kraków, Poland, between 2008 and 2018. The study group consisted of children examined in two cross-sectional studies. Analysed characteristics included triceps, calf, subscapular, abdominal and suprailiac skinfold thicknesses, and adiposity calculated according to Slaughter’s equations. The trunk adiposity index and limbs-to-trunk fat ratio were also calculated. Statistical significance was obtained using two-way ANOVA and Tukey’s tests. Lower-limb adiposity was largest in the 2008 cohort and trunk adiposity was greater in the 2018 cohort. The mean values of the trunk adiposity index and limbs-to-trunk fat ratio were lower in the 2018 cohort than in the 2008 cohort. The 2018 cohort was also characterized by a lower overall adiposity. Regardless of the lower body adiposity percentage, in 2018 there was a tendency towards the central allocation of fat tissue. This is a negative phenomenon because, especially when co-existing with reduced lower-limb adiposity, it is associated with an increased risk of metabolic and cardiovascular diseases, even in young children.
Patients’ knowledge and awareness about patient support programs: a cross-sectional study on Lebanese adults with chronic diseases
Authors: Abbas Hanine , Yehya Layal , Kurdi Mazen , Karam Rita 
Published: February 2021

Abstract

Objective
Patient Support Programs (PSPs) have become a trend among pharmaceutical companies and a standard service offering to patients. The objective of the present study is to describe the status of PSPs in Lebanon and to assess the extent of knowledge and awareness among Lebanese patients about the PSPs.

Methods
A cross-sectional study was conducted between April and July 2017. A convenient sample of patients was randomly selected from outpatient clinics at four hospitals within the Greater Beirut Area. A questionnaire was used to address the study objective. Bivariate analysis was performed using the Chi-square test. Data were analyzed by using SPSS version 23.

Results
Out of 385 patients who participated in the study, 45.45 percent were aged between 46 and 66 years. None of them indicated that they were enrolled in a PSP, and only 13 percent of the respondents were aware of the existence of such a program. In terms of adherence habits, 55.6 percent of the patients self-reported that they do not skip any dose of their medication and consume their medication as prescribed by their healthcare providers. The main reason for nonadherence reported by the majority of nonadherent participants 144 (84.2%) was simple forgetfulness.

Conclusions
There is a severe lack of awareness of PSPs in Lebanon. Given the important role that PSPs play in creating value for patients—in terms of healthcare follow-up practices, improved adherence habits, and cost savings—there should be a more substantial effort by pharmaceutical companies to expand and promote their PSPs in the Lebanese market.
A variant of the Corners theorem
Authors: MANDACHE MATEI 
Published: February 2021

AbstractThe Corners theorem states that for any α > 0 there exists an N0 such that for any abelian group G with |G| = N ≥ N0 and any subset A ⊂ G×G with |A| ≥ αN2 we can find a corner in A, i.e. there exist x, y, d ∈ G with d ≠ 0 such that (x,y),(x+d,y),(x,y+d) ∈ A.Here, we consider a stronger version, in which we try to find many corners of the same size. Given such a group G and subset A, for each d ∈ G we define Sd={(x,y) ∈ G × G: (x,y),(x+d,y),(x,y+d) ∈ A}. So |Sd| is the number of corners of size d. Is it true that, provided N is sufficiently large, there must exist some d ∈G\{0} such that |Sd|>(α3-ϵ)N2?We answer this question in the negative. We do this by relating the problem to a much simpler-looking problem about random variables. Then, using this link, we show that there are sets A with |Sd|>Cα3.13N2 for all d ≠ 0, where C is an absolute constant. We also show that in the special case where $G = {\mathbb{F}}_2^n$, one can always find a d with |Sd|>(α4-ϵ)N2.
A compact UWB antenna with dynamically switchable band-notched characteristic using broadband rectenna and DC-DC booster
Authors: Fakharian Mohammad M. 
Published: February 2021

AbstractIn this article, a dynamically switchable ultra-wideband (UWB) planar monopole antenna employing defected ground structure (DGS) with a folded stepped impedance resonator (SIR) that can operate as either a UWB mode or the single band-notched mode is introduced. The UWB monopole antenna contains a novel whirligig-shaped radiating patch and a chambered conductor as a partial ground plane. The switchable UWB antenna uses one PIN diode as switching elements in the DGS-SIR structure without any biasing network. When the state of diode is OFF, the planar monopole antenna changes to the UWB mode, and when the diode is turned ON, a frequency notch is created at 5–6 GHz. The state of diode is set to the “ON” state dynamically in the presence of a 5–6 GHz RF signal that is detected by using a wireless power management unit (PMU) that contains a broadband rectenna and a DC-DC passive booster. The rectenna consists of a novel cypress-shaped monopole antenna as a signal receiving part and two sub-rectifiers which are connected to a 3 dB branch-line coupler with a grounded isolation port. The antenna switches from UWB to single band-notched when an RF input signal (≥8.5 dBm) in the 5.25 GHz is sensed by the RF PMU with a conversion efficiency of 26% and DC output voltage of 0.36 V, and it fades immediately in real time when the external RF signal is eliminated. In the three-tone signals, the efficiency and input signal improvements are about 10% and −5.5 dBm in the low-power levels, especially, and so develop and enhance the performance of the dynamic reconfigurability.
Inter-row cultivation timing effects on waterhemp (Amaranthus tuberculatus) control and sugarbeet yield and quality
Authors: Haugrud Nathan H. , Peters Thomas J. 
Published: February 2021

AbstractThe invasion of waterhemp into northern sugarbeet growing regions has prompted producers to re-integrate inter-row cultivation into weed management programs, as no currently registered herbicides can control glyphosate-resistant waterhemp POST in crop. Inter-row cultivation was a common weed control practice in sugarbeet until the release of glyphosate-resistant sugarbeet cultivars in 2008 made the use of inter-row cultivation unnecessary. In the late 2010s, producers began again to use inter-row cultivation to remove weeds that glyphosate did not control, but producers need information on the effectiveness and safety of inter-row cultivation when used with soil-residual herbicide programs. Efficacy and tolerance field experiments were conducted in Minnesota and North Dakota from 2017 to 2019. Results from the efficacy experiment demonstrated that cultivation improved waterhemp control 11% and 12%, 14 and 28 d after treatment, respectively. Waterhemp response to cultivation was dependent on crop canopy and precipitation after cultivation. Cultivation had minimal effect on waterhemp density in three environments, but at one environment, near Galchutt, ND in 2019, waterhemp density increased 600% and 196%, 14 and 28 d after treatment, respectively. Climate data indicated that in 2019 Galchutt, ND received 105 mm of precipitation in the 14 d following cultivation and had an open crop canopy that probably contributed to further weed emergence. Results from the tolerance experiment demonstrated that root yield and recoverable sucrose were not affected by cultivation timing or number of cultivations. In one environment, cultivating reduced sucrose content by 0.8% regardless of date or cultivation number, but no differences were found in four environments. Damage/destruction of leaf tissue from in-season cultivation is probably responsible for the reduction in sucrose content. Results indicate that cultivation can be a valuable tool to control weeds that herbicide cannot, but excessive rainfall and open crop canopy following cultivation can create an environment conducive to further weed emergence.
Cross-resistance to diquat in glyphosate/paraquat-resistant hairy fleabane (Conyza bonariensis) and horseweed (Conyza canadensis) and confirmation of 2,4-D resistance in Conyza bonariensis
Authors: Moretti Marcelo L. , Bobadilla Lucas K. , Hanson Bradley D. 
Published: February 2021

AbstractHairy fleabane and horseweed are pervasive weed species in agriculture. Glyphosate-resistant (GR) and glyphosate/paraquat–resistant (GPR) biotypes challenge current management strategies. These GR and GPR biotypes have non–target site resistance, which can confer resistance to herbicides with different sites of action (SOAs). This study’s objective was to characterize the response of GR, GPR, and glyphosate/paraquat–susceptible (GPS) biotypes of both weed species to herbicides with a different SOA. Whole-plant dose–response bioassays indicated a similar response among tested biotypes of both weed species to rimsulfuron, dicamba, hexazinone, glufosinate, flumioxazin, saflufenacil, or mesotrione. The hairy fleabane GR and GPR biotypes were 2.7- and 2.9-fold resistant to 2,4-D relative to the GPS biotype (GR50 766.7 g ai ha–1), confirming 2,4-D resistance in hairy fleabane for the first time in California. The GR and GPR biotypes were not cross-resistant to dicamba. No differences in response to 2,4-D were observed among horseweed biotypes with a GR50 ranging from 150.2 to 277.4 g ai ha–1. The GPR biotypes of both species were cross-resistant to diquat, with a 44.0-fold resistance in hairy fleabane (GR50 863.7 g ai ha–1) and 15.6-fold resistance in horseweed (GR50 563.1 g ai ha–1). The confirmation of multiple resistances to glyphosate, paraquat, and 2,4-D in hairy fleabane curtails herbicide SOA alternatives and jeopardizes resistance management strategies based on herbicide rotation and tank mixtures, underscoring the critical need for nonchemical weed control alternatives.
A mycovirus modulates the endophytic and pathogenic traits of a plant associated fungus
Authors: Zhou Lingling , Li Xuepei , Kotta-Loizou Ioly , Dong Kaili , Li Shifang , Ni Dejiang , Hong Ni , Wang Guoping , Xu Wenxing 
Published: February 2021

Abstract
Fungi are generally thought to live in host plants with a single lifestyle, being parasitism, commensalism, or mutualism. The former, known as phytopathogenic fungi, cause various plant diseases that result in significant losses every year; while the latter, such as endophytic fungi, can confer fitness to the host plants. It is unclear whether biological factors can modulate the parasitic and mutualistic traits of a fungus. In this study, we isolated and characterized a mycovirus from an endophytic strain of the fungus Pestalotiopsis theae, a pathogen of tea (Camellia sinensis). Based on molecular analysis, we tentatively designated the mycovirus as Pestalotiopsis theae chrysovirus-1 (PtCV1), a novel member of the family Chrysoviridae, genus Alphachrysovirus. PtCV1 has four double-stranded (ds) RNAs as its genome, ranging from 0.9 to 3.4 kbp in size, encapsidated in isometric particles. PtCV1 significantly reduced the growth rates of its host fungus in vitro (ANOVA; P-value &lt; 0.001) and abolished its virulence in planta (ANOVA; P-value &lt; 0.001), converting its host fungus to a non-pathogenic endophyte on tea leaves, while PtCV1-free isolates were highly virulent. Moreover, the presence of PtCV1 conferred high resistance to the host plants against the virulent P. theae strains. Here we report a mycovirus that modulates endophytic and phytopathogenic fungal traits and provides an alternative approach to biological control of plant diseases caused by fungi.
Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether
Authors: Xia Yingchun , Song Ziyuan , Tan Zhengzhong , Xue Tianrui , Wei Shiqi , Zhu Lingyang , Yang Yingfeng , Fu Hailin , Jiang Yunjiang , Lin Yao , Lu Yanbing , Ferguson Andrew L. , Cheng Jianjun 
Published: February 2021

AbstractThe recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) enriched the toolbox to prepare well-defined polypeptide materials. Herein we report the use of crown ether (CE) to catalyze the polymerization of NCA initiated by conventional primary amine initiators in solvents with low polarity and low hydrogen-bonding ability. The cyclic structure of the CE played a crucial role in the catalysis, with 18-crown-6 enabling the fastest polymerization kinetics. The fast polymerization kinetics outpaced common side reactions, enabling the preparation of well-defined polypeptides using an α-helical macroinitiator. Experimental results as well as the simulation methods suggested that CE changed the binding geometry between NCA and propagating amino chain-end, which promoted the molecular interactions and lowered the activation energy for ring-opening reactions of NCAs. This work not only provides an efficient strategy to prepare well-defined polypeptides with functionalized C-termini, but also guides the design of catalysts for NCA polymerization.
Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy
Authors: Dehdashti Farrokh , Wu Ningying , Ma Cynthia X. , Naughton Michael J. , Katzenellenbogen John A. , Siegel Barry A. 
Published: February 2021

AbstractEstrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after a one-day estradiol challenge. In 43 postmenopausal women with advanced ER+ breast cancer, we show a post-challenge increase in tumor FFNP uptake only in 28 subjects with clinical benefit from ET (responders), but not in 15 without clinical benefit (nonresponders) (p < 0.0001), indicating 100% sensitivity and specificity. We further show significantly longer survival (p < 0.0001) in the responding subjects. Our results demonstrate that change in tumor FFNP uptake after estradiol challenge is highly predictive of response to ET in women with ER+ breast cancer.