bluuebunny/crossref_metadata_2025_split huggingface dataset:
Death, Innocence, and the Cyborg: Theorizing the Gynoid Double-Bind in Mamoru Oshii’s Ghost in the Shell II: Innocence
Authors: Tembo Kwasu D. 
Published: April 2021

Abstract
In Donna Haraway’s “A Cyborg Manifesto” (1983), the author presents a discussion of the concept and praxis of the cyborg in emancipatory terms. Haraway presents the cyborg as a transgressive and latently mercurial figure that decouples and contravenes numerous exploitative ideological frameworks of repressive biopower that repress human being and reproduce the conditions of said repression. Using Mamoru Oshii’s Ghost in the Shell II: Innocence (2004) as a dialogic case study, this essay explores the manner in which the cyborg, particularly its figuration as female-gendered anthropic machine or gynoid in 20th- and 21st-century science fiction, simultaneously confirms and contradicts Haraway’s assessment of the concept of the cyborg. As to its methodology, this essay opens with a contextualizing excursus on the cyber-being in contemporary Western society and sociopolitics, with a view to offering a framework analysis of the figuration of the gynoid in Oshii’s Ghost in the Shell II: Innocence as a recent example of contemporary science fiction’s representation of the issues and debates inherent to the concept of the gynoid. Lastly, this essay performs a detailed close reading of Oshii’s text in relation to its exploration of themes of the conceptual emancipatory potential of the cyber-being and the paradoxically exploitative patriarchal power relations that re-inscribe said potential within what this essay refers to as ‘the gynoid double-bind.’
Vector bundles 𝐸 on ℙ3 with homological dimension 2 and 𝜒(End 𝐸) = 1
Authors: Mendes Sérgio , Miró-Roig Rosa María , Soares Helena 
Published: April 2021

Abstract
We find the complete integer solutions of the equation

X
2

+

Y
2

+

Z
2

-

4
⁢
X
⁢
Y

-

4
⁢
Y
⁢
Z

+

10
⁢
X
⁢
Z

=
1

X^{2}+Y^{2}+Z^{2}-4XY-4YZ+10XZ=1

.
As an application, we prove that, for each solution

(
a
,
b
,
c
)

(a,b,c)

such that

a
>
0

a>0

,

b
-

2
⁢
a

>
0

b-2a>0

and

(

b
-

2
⁢
a

)

2

≥

4
⁢
a

(b-2a)^{2}\geq 4a

, there is a vector bundle 𝐸 on

P
3

\mathbb{P}^{3}

defined by a minimal linear resolution

0
→

O

P
3

⁢

(

-
2

)

a

→

O

P
3

⁢

(

-
1

)

b

→

O

P
3

c

→
E
→
0

0\to\mathcal{O}_{\mathbb{P}^{3}}(-2)^{a}\to\mathcal{O}_{\mathbb{P}^{3}}(-1)^{b}\to\mathcal{O}_{\mathbb{P}^{3}}^{c}\to E\to 0

.
In particular, 𝐸 satisfies

χ
⁢

(

End
⁡
E

)

=
1

\chi(\operatorname{End}E)=1

.
Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase
Authors: Lamers Sebastiaan , Feng Qiaoli , Cheng Yili , Yu Sihong , Sun Bo , Lukman Maxwell , Jiang Jie , Ruiz-Carrillo David 
Published: April 2021

Abstract

Porphyromonas gingivalis is a bacterial species known to be involved in the pathogenesis of chronic periodontitis, that more recently has been as well associated with Alzheimer’s disease. P. gingivalis expresses a glutaminyl cyclase (PgQC) whose human ortholog is known to participate in the beta amyloid peptide metabolism. We have elucidated the crystal structure of PgQC at 1.95 Å resolution in unbound and in inhibitor-complexed forms. The structural characterization of PgQC confirmed that PgQC displays a mammalian fold rather than a bacterial fold. Our biochemical characterization indicates that PgQC uses a mammalian-like catalytic mechanism enabled by the residues Asp149, Glu182, Asp183, Asp218, Asp267 and His299. In addition, we could observe that a non-conserved Trp193 may drive differences in the binding affinity of ligands which might be useful for drug development. With a screening of a small molecule library, we have identified a benzimidazole derivative rendering PgQC inhibition in the low micromolar range that might be amenable for further medicinal chemistry development.
Exploring the inter-subject variability in the relationship between glucose monitoring metrics and glycated hemoglobin for pediatric patients with type 1 diabetes
Authors: Bosoni Pietro , Calcaterra Valeria , Tibollo Valentina , Malovini Alberto , Zuccotti Gianvincenzo , Mameli Chiara , Sacchi Lucia , Bellazzi Riccardo , Larizza Cristiana 
Published: April 2021

Abstract

Objectives
Despite the widespread diffusion of continuous glucose monitoring (CGM) systems, which includes both real-time CGM (rtCGM) and intermittently scanned CGM (isCGM), an effective application of CGM technology in clinical practice is still limited. The study aimed to investigate the relationship between isCGM-derived glycemic metrics and glycated hemoglobin (HbA1c), identifying overall CGM targets and exploring the inter-subject variability.

Methods
A group of 27 children and adolescents with type 1 diabetes under multiple daily injection insulin-therapy was enrolled. All participants used the isCGM Abbott’s FreeStyle Libre system on average for eight months, and clinical data were collected from the Advanced Intelligent Distant-Glucose Monitoring platform. Starting from each HbA1c exam date, windows of past 30, 60, and 90 days were considered to compute several CGM metrics. The relationships between HbA1c and each metric were explored through linear mixed models, adopting an HbA1c target of 7%.

Results
Time in Range and Time in Target Range show a negative relationship with HbA1c (R2>0.88) whereas Time Above Range and Time Severely Above Range show a positive relationship (R2>0.75). Focusing on Time in Range in 30-day windows, random effect represented by the patient’s specific intercept reveals a high variability compared to the overall population intercept.

Conclusions
This study confirms the relationship between several CGM metrics and HbA1c; it also highlights the importance of an individualized interpretation of the CGM data.
Unterwegs zum Ökumenischen Kirchentag (ÖKT)
Authors: Miron Radu Constantin 
Published: April 2021

Zusammenfassung
Aus der Perspektive des ACK-Vorsitzes und gleichzeitig aus der Perspektive des orthodoxen Ökumenikers, der auch Mitglied im Präsidium des 3. ÖKT ist, stellt dieser Artikel die Ideen des Ökumenischen Kirchentags 2021 vor. Er reflektiert die Situation der ‚hierzulande kleinen Kirchen‘, das Konzept der ACK-‚Polis‘ und das Motto des ÖKT.
Auf nach Karlsruhe
Authors: Bosse-Huber Petra 
Published: April 2021

Zusammenfassung
Aus der Perspektive der größten der gastgebenden Kirchen wird in diesem Artikel die Vorbereitung der 11. Vollversammlung des Ökumenischen Rates der Kirchen (ÖRK) beschrieben, die in Deutschland stattfinden soll und wegen der Corona-Pandemie in das Jahr 2022 verschoben werden musste. Er gibt einen Überblick über die Themen, die die Vollversammlung bearbeiten wird und beschreibt am Ende die Erwartungen und Hoffnungen, die die Autorin für die Ökumene im Besonderen und für das Zusammenleben der Menschen weltweit auf die Vollversammlung setzt.
In seasonal body composition and jump performance variation in a second league male volleyball team
Authors: Reitmayer Hans-Eric 
Published: April 2021

Abstract
Volleyball has become a sport of the giants. Under these circumstances it is desirable that players of a very large stature also possess a corresponding vertical jump. The aim of the paper was to identify the values of some parameters that we considered crucial in limiting or maximizing the in-game performance of the athletes in the study. Our intention was to verify if the body composition indicators change significantly at different stages of a competition season and if the characteristics of the jump, crucial in performing the actions through which the points arescored, are relevant in determining the level of physical conditioning. Twelve players (n=12) were selected from the second league Romanian male volleyball team CSU UVT. The subjects were tested for body composition and their spike jump and counter movement jump was measured on three separate occasions, each corresponding to a different stage of training.
Study results highlighted a significant increase of 1.15kg (p=0.028) in weight at the intermediate testing compared to the initial values. There were no differences in muscle mass between the initial and the intermediate testing (p=0.88). The results have shown a significant increase of the average skeletal muscle mass in the final test by 0.77 kg over the intermediate test (p=0.012) and 0.81kg over the initial test (p=0.039).We recorded a considerable increase of body fat mass between initial and intermediate testing (p=0.0073) and there was an average decrease of 1.76 kg (p=0.0285) of body fat mass between intermediate and final testing.
We have seen a significant increase in the height of the spike jump at the final test compared to the intermediate testing (p<0.0001) respectively the initial testing (p<0.0001).The counter movement jump recorded a significant decrease in the intermediate test 37.58 cm, compared to the initial test 40.57 cm (p=0.014).. Final measurements of the counter movement jump height increase in relation to intermediate testing (p=0.037).
Measurements also indicate a direct correlation between the height and power developed during the jump in all the three tests: initial (r=0.76), intermediate (r=0.68) and final (r=0.84).
Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology
Authors: Martusevich Andrew K. , Zagrekov Valery I. , Belyaeva Ksenia L. , Pushkin Alexander S. , Soloveva Anna G. 
Published: April 2021

Introduction: The purpose of this study was to evaluate and compare the features of the initiation and development of oxidative stress in patients with osteomyelitis and burns.
Methods: We studied the oxidative metabolism of blood of 20 healthy subjects (controls), 15 patients with burns, and 18 patients with chronic osteomyelitis. All patients included in the second group had thermal burns of the I-II-III degree in trunk and limbs on an area of 31-80% of the body surface without thermal inhalation trauma. After standard sample preparation, a wide range of parameters of oxidative metabolism was determined in the blood. The intensity of free radical processes in blood plasma and red blood cells, and the total antioxidant activity was evaluated by Fe-induced biochemiluminescence. The concentration of malonic dialdehyde in blood plasma and red blood cells was determined. The level of diene and triene conjugates and Schiff bases was determined spectrophotometrically using reagent kits. The catalase and superoxide dismutase activities in the red blood cells of patients from each of the groups was also determined.
Results: We showed that in osteomyelitis, which is a long-lasting process, changes in the balance of free radical generation and activity of the antioxidant system were compensatory and mostly related to changes in blood plasma. On the contrary, in burn victims, oxidative stress signs had a maladaptive character. They were seen in blood plasma and red blood cells, and accompanied by a pronounced depletion of enzyme antioxidant system reserves.
Conclusion: Our study demonstrate the role of oxidative stress in patients with burns and chronic osteomyelitis, and demonstrate some specific features leading to formation of disease pathology. Such features of oxidative stress may be useful in future design of new approaches to correct the pathology of diseases.
The AI Liability Puzzle and A Fund-Based Work-Around
Authors: Erdelyi Olivia J. , Erdelyi Gabor 
Published: April 2021

Confidence in the regulatory environment is crucial to enable responsible AI innovation and foster the social acceptance of these powerful new technologies. One notable source of uncertainty is, however, that the existing legal liability system is unable to assign responsibility where a potentially harmful conduct and/or the harm itself are unforeseeable, yet some instantiations of AI and/or the harms they may trigger are not foreseeable in the legal sense. The unpredictability of how courts would handle such cases makes the risks involved in the investment and use of AI difficult to calculate with confidence, creating an environment that is not conducive to innovation and may deprive society of some benefits AI could provide. To tackle this problem, we propose to draw insights from financial regulatory best practices and establish a system of AI guarantee schemes. We envisage the system to form part of the broader market-structuring regulatory frameworks, with the primary function to provide a readily available, clear, and transparent funding mechanism to compensate claims that are either extremely hard or impossible to realize via conventional litigation. We propose it to be at least partially industry-funded. Funding arrangements should depend on whether it would pursue other potential policy goals aimed more broadly at controlling the trajectory of AI innovation to increase economic and social welfare worldwide. Because of the global relevance of the issue, rather than focusing on any particular legal system, we trace relevant developments across multiple jurisdictions and engage in a high-level, comparative conceptual debate around the suitability of the foreseeability concept to limit legal liability. The paper also refrains from confronting the intricacies of the case law of specific jurisdictions for now and—recognizing the importance of this task—leaves this to further research in support of the legal system’s incremental adaptation to the novel challenges of present and future AI technologies.
This article appears in the special track on AI and Society.
The effectiveness of the combined use of RF therapy and laser technology in the correction of involutive changes in the skin of the face
Authors: Kruchinskaya Marina G. , Manturova Natalya E. , Stenko Anna G. 
Published: April 2021

Bipolar radio-frequency devices have all the theoretical prerequisites for use in combination with phototechnologies, while the properties of electro-optical synergy are manifested.
Material and method. The study included 125 patients aged 40 to 50 years. Depending on the therapy, patients were divided into 4 groups and subgroups A and B, depending on the identified predictors of the effectiveness of laser therapy.
The results of the study. After applying the combined methods, a more significant improvement in the quality characteristics of the skin was noted: an increase in skin moisture in the 1A group, the corneometry index increased by 24.6%, in the 1st group by 28.3%, in the 2A group by 38.9%, in the 2B group by 37.3%, in the 3A group by 29.1%, in the 3B group by 27.5%, in the 4A group by 38.8%, in the 4B group by 38.8%; an increase in skin elasticity in group 1A, the Ua/Uf indicator increased by 13.2%, in group 1B by 13.9%, in group 2A by 27.9%, in group 2B by 29.0%, in group 3A by 14.9%, in the 3B group by 14.6%, in the 4A group by 28.2%, in the 4B group by 28.2%, which was accompanied by a more pronounced decrease in the severity of wrinkles according to profilometry. The use of laser therapy (an erbium or neodymium laser) and microneedle RF therapy contributes to a more significant restoration of the epidermal-dermal structure of the skin, which is confirmed by ultrasound data: the microrelief has improved by more than 3 times compared with monotherapy, the thickness of the dermis is 2.2 times and acoustic density 1.7 times.
Conclusions. Combined methods, to a greater extent than mono-laser therapy, contribute to improving the quality of life of patients according to the dynamics of the LHC index, which decreased in groups 1 and 3 by an average of 47.1% and 44.4% versus 57.8% and 64.3% in 2 and 4 groups, while there was a significant difference in the values of the index of HSCI in groups A and B (p 0.01). In accordance with the VAS and GAIS indicators, the optimal effect after a course of therapy with preservation of the results after 1 year was achieved in 25/12.5% of patients in group 1A, in 46.7/33.3% in group 1B, 7/37.5% of patients of group 2A, 78.6/71.4% of patients of group 2B, 33.3/20.0% of patients of group 3A, 50.0/25% of patients 3B groups, 58.8/58.8% and 75.0/75.0% in patients 4A and 4B of the group, respectively, which indicates the high efficiency of the combined methods and the persistence of the results.
Correction of psychoemotional and vascular-autonomic dysfunction with patients suffering from endometrial disease under the influence of complex radon, laser, and drug treatment
Authors: Ahkubekova Nelly K. , Tereshin Anatoly T. , Bestaeva Angela E. 
Published: April 2021

The research objective is to develop a program to correct psycho-emotional and vascular-autonomic dysfunction with patients suffering from adenomyosis using complex radon, laser and drug treatment.
Material and methods. There were 100 women with adenomyosis complicated by psycho-emotional and vascular-autonomic dysfunction from the age of 23 up to 37 years old who underwent treatment at a branch of Pyatigorsk Clinic of North Caucasian Federal Scientific and Clinical Centre of Federal Medical and Biological Agency of Russia. The patients were divided into 2 groups by a randomized method: the main group received radon, laser and drug therapy with Melaxen, the group of comparison received radon and laser therapy.
Results. A comparative analysis showed the expediency of including adaptogens in the complex of sanatorium-and-spa treatment of patients with endometrial disease: the improvement of clinical symptoms in the main group compared to the group of comparison was more frequent by 1.36 times; normalization of vegetative management in the main group occurred with 72% of the patients compared to 52% in the group of comparison; in the main group the decrease in the intensity of anxious disorders was 2.64 times (p 0.01), against 1.46 times in the group of comparison (p 0.05); normalization of concentration of peptide and steroid hormones in blood serum in the main group was with 64% of the patients versus 42% in the group of comparison.
Conclusion. Inclusion of Melaxen in the complex of traditional sanatorium-and-spa treatment of patients with adenomyosis (radon and laser therapy) provides significant improvement of neuroendocrine system, psycho-emotional, vegetative-vascular status.
Justifcation for the usage of mineral water of Teberda deposit in the treatment of patients with focal pulmonary tuberculosis
Authors: Gerbekova Dinara Yu. 
Published: April 2021

The purpose of the research is scientifically substantiate the use of drinking mineral waters (MW) of Teberdinskiy deposit in sanatorium and spa treatment of patients suffering from focal pulmonary tuberculosis (FPT).
Material and methods. The study included 80 patients with FPT in the resorption and carnification phase. By random sampling, we formed 2 groups: the control group (CG; 40 people) that received inhalations with 1% dioxidin solution and a standard drug anti-tuberculosis chemotherapy; the patients of the group of comparison (GC; 40 people) additionally received drinking MW "Teberda."
Results. The analysis of clinical symptom dynamics did not show any significant differences between the groups: by the end of sanatorium-and-spa treatment the leveling of clinical symptoms in the MG was with 98.3% of the cases, in the CG with 88.8%. The patients of the MG had a normalization of related T-lymphocyte subpopulations, immunoregulatory index decreased by 39.2% (p 0.01), there was a drop in intensity of free radical oxidation by 30.2% (p 0.01), an increase in activity of antioxidant protection system by 17.2% (p 0.05). The CG had only a tendency to improvement of laboratory indicators.
Conclusion. In order to achieve a higher therapeutic effect having FPT in the resorption and carnification phase, it is advisable to include drinking MW in the treatment program, which expands and complements the possibilities of rehabilitation and rehabilitation assistance to the given group of patients.
THE EFFECTS OF EDUCATION ON THE MAJOR LIFE ACTIVITIES OF ROAD TRAFFIC INJURY VICTIMS CONCERNING HEALTH SATISFACTION STATUS
Authors: Waqas  , Alam Intikhab , Shah Mussawar , Nawab Khalid 
Published: April 2021

Purpose of the study: To examine the satisfaction of the health status of RTI victims and to measure the association between the satisfaction of health status with the prevailing level of participation of RTI victims in various major life activities.
Methodology: This study follows a cross-sectional research design. A comprehensive interview schedule was designed and pre-tested before the actual process of data collection. For data analysis, SPSS v.20 was run for obtaining univariate, bivariate, and multivariate analysis.
Main Findings: At a bivariate level, it was found that RTI victims were having difficulty in walking, standing, sitting, and dysfunctional memory status had significantly associated with low health satisfaction. Furthermore, at the multivariate level, the victims with low educational status were more likely to report limitations in Major Life Activities (MLA), ultimately affecting their health satisfaction status.
Applications of this study: This research's findings can apply to such studies that emphasize the sociological perspectives for minimizing traffic crashes. Moreover, it also provides the role of education in controlling traffic injuries in the south Asian region.
Novelty/Originality of this study: This study is the first-ever attempt to determine the effects of MLA limitations on the health satisfaction status. Apart from describing the phenomenon from a sociological perspective, the article also enlightens the role of education in minimizing RTI injuries.