bluuebunny/crossref_metadata_2025_split huggingface dataset:
A measurement framework for assessing the digital transformation of cultural institutions: the Italian case
Authors: Agostino Deborah , Costantini Chiara 
Published: November 2021

Purpose
Public and private sector organisations are widely endorsing digital transformation processes, but little is known about the level of digitalisation of an organisation as a whole. The purpose of this paper is to develop a framework to assess an organisation’s level of digital transformation as a whole, taking the field of museums as an exemplary case of application.

Design/methodology/approach
The framework draws upon a scoping literature review of studies examining dimensions, metrics and methods for the assessment of the digital transformation of organisations. The framework has been validated by applying it to a sample of 400 Italian museums and further interviews with museum directors.

Findings
The authors propose an assessment framework composed of five main dimensions: people, technology, process, customer and strategy and investment. These dimensions are further deployed in sub-dimensions measured through a set of questions. The weighted average of results per dimension and sub-dimension supported the development of a composite index of organisational digital readiness.

Originality/value
The developed framework contributes to the current debate on the measurement of an organisation’s level of digital transformation as a whole, and it can offer practitioners a managerial tool to assess the organisation’s digital readiness.
Analysing the criteria for measuring the determinants of virtual reality technology adoption in real estate agency practice in Lagos: a DEMATEL method
Authors: Adegoke Ayodele Samuel , Oladokun Timothy Tunde , Ayodele Timothy Oluwafemi , Agbato Samson Efuwape , Jinadu Ahmed Demola , Olaleye Sulaimon Olawale 
Published: November 2021

PurposeThis study aims to analyse the criteria used in measuring the determinants of the adoption of virtual reality (VR) technology in real estate agency practice in Lagos, with a view to providing information with which the practice can be enhanced.Design/methodology/approachThe data for the study were elicited using a questionnaire which was administered to eight real estate firms (REFs). The firms were those that have been operating in Lagos for at least five years, and the data collected were analysed using the DEMATEL method.FindingsThe findings revealed that perceived utility and relative advantage were the most important criteria for determining REFs' performance expectancy with VR technology. The two most important criteria to measure effort expectancy were “perceived ease of use” and complexity. “Subjective norms” was the most important criterion for measuring social influence, while “perceived behavioural control” was the most important criterion to measure facilitating conditions. Under “price value”, output quality was the only significant criterion. Finally, the frequency of use, the actual number of use and the amount of time spent utilising the technology were significant for measuring the REFs' use behaviour.Practical implicationsThe study offers insights into the criteria that can assist REFs in integrating VR technology into real estate agency practice. The results are also helpful to the Nigerian real estate professional bodies to organise workshop programmes for REFs on the use of VR technology and other disruptive technologies. The results will also serve as a guide for REFs to gain a competitive advantage in this trying time of pandemic and help them measure up to global standards and the expectations of their clients.Originality/valueBefore this study, efforts have not been made to study the criteria for measuring the determinants of VR technology adoption in the Nigerian real estate agency practice.
Expression and diversity of the sialic acid–binding adhesin and its homologs associated with oral streptococcal infection
Authors: Ishikawa Yuiko , Saiki Keitarou , Urano‐Tashiro Yumiko , Yamanaka Yuki , Takahashi Yukihiro 
Published: November 2021

AbstractStreptococcus gordonii, one of the early colonizers of oral biofilms, is involved in the development of dental caries, periodontal disease, and infective endocarditis. The Hsa adhesin of S. gordonii DL1 has the ability to bind strongly to the terminal sialic acid groups of host glycoproteins via the binding region, nonrepetitive region 2 (NR2), which is important for the pathogenicity of S. gordonii DL1. Low similarity with the NR2 of Hsa homologs among other streptococcal species has been reported. However, the reports have been limited to certain strains. This study attempted to assess frequency of the expression on the bacterial cell surface and to analyze the diversity of Hsa homologs among different wild strains of oral streptococci. We isolated 186 wild‐type strains of oral streptococci from healthy volunteers and analyzed their hemagglutinating (HA) activity on human erythrocytes and their Hsa homologs and NR2 homologous regions by dot immunoblotting using anti‐Hsa and anti‐NR2 antisera, respectively. We found 30 strains reacted with anti‐NR2 antiserum (NR2 positive) and determined the sequence of the NR2 regions. Many strains with high HA activity were also NR2 positive, suggesting that the NR2 region may be associated with HA activity. Among the NR2‐positive strains, four different amino acid sequence patterns were observed, demonstrating diversity in the NR2 region. Notably, S. gordonii strains frequently possessed Hsa homologs and NR2‐like antigens compared with other streptococci. It is speculated that the possessing frequency of Hsa homologs and the amino acid sequence of NR2 region may vary among streptococcal species.
Positive forest cover effects on coffee yields are consistent across regions
Authors: González‐Chaves Adrian , Carvalheiro Luísa G. , Garibaldi Lucas A. , Metzger Jean Paul 
Published: November 2021

Abstract

Enhancing biodiversity‐based ecosystem services can generate win–win opportunities for conservation and agricultural production. Pollination and pest control are two essential agricultural services provided by mobile organisms, many depending on native vegetation networks beyond the farm scale. Many studies have evaluated the effects of landscape changes on such services at small scales. However, several landscape management policies (e.g. selection of conservation sites) and associated funding allocation occur at much larger spatial scales (e.g. state or regional level). Therefore, it is essential to understand whether the links between landscape, ecosystem services and crop yields are robust across broad and heterogeneous regional conditions.

Here, we used data from 610 Brazilian municipalities within the Atlantic Forest region (~50 Mha) and show that forest is a crucial factor affecting coffee yields, regardless of regional variations in soil, climate and management practices. We found forest cover surrounding coffee fields was better at predicting coffee yields than forest cover at the municipality level. Moreover, the positive effect of forest cover on coffee yields was stronger for Coffea canephora, the species with higher pollinator dependence, than for Coffea arabica. Overall, coffee yields were highest when they were near to forest fragments, mostly in landscapes with intermediate to high forest cover (>20%), above the biodiversity extinction threshold.

Coffee cover was the most relevant management practice associated with coffee yield prediction. An increase in crop area was associated with a higher yield, but mostly in high forest covers municipalities. Other localized management practices like irrigation, pesticide use, organic manure and honeybee density had little importance in predicting coffee yields than landscape structure parameters. Neither the climatic or topographic variables were as relevant as forest cover at predicting coffee yields.

Synthesis and application. Our work provides evidence that landscape relationships with ecosystem service provision are consistent across regions with different agricultural practices and environmental conditions. These results provide a way in which landscape management can articulate small landscape management with regional conservation goals. Policies directed towards increasing landscape interspersion of coffee fields with forest remnants favour spillover process, and can thus benefit the provision of biodiversity‐based ecosystem services, increasing agricultural productivity. Such interventions can generate win–win situations favouring biodiversity conservation and increased crop yields across large regions.
Delays in Banks’ Loan Loss Provisioning and Economic Downturns: Evidence from the U.S. Housing Market
Authors: KIM SEHWA 
Published: November 2021

ABSTRACTI study whether banks’ loan loss provisioning contributes to economic downturns, by examining the U.S. housing market. Specifically, I examine the aggregate effects of banks’ delayed loan loss recognition (DLR) on house prices during the Great Recession and the channels through which these potential effects arose. I construct ZIP‐code‐level exposure to banks’ DLR before the crisis and compare high‐ and low‐exposure ZIP codes during the crisis to examine the aggregate effects of banks’ DLR on the housing market. I find that high‐exposure ZIP codes experienced larger decreases in mortgage supply, larger increases in distressed sales, and larger decreases in house prices during the crisis. In addition, I conduct individual bank‐level analyses and find that high‐DLR banks reduced their mortgage supply more than low‐DLR banks, and mortgages issued by high‐DLR banks were more likely to become distressed during the crisis. Taken together, these findings suggest that banks’ DLR was associated with nontrivial effects on the housing market during the Great Recession, and the effects of DLR on house prices were likely driven by both the credit‐crunch and distressed‐sales channels.
Willingness to Accept for Perennial Crop Adoption: The Influence of Trust in Environmental and Government Organizations
Authors: Levers Lucia R. , Pradhananga Amit K. , Peterson Jeffrey M. 
Published: November 2021

AbstractReplacing corn crops with perennial species can decrease sedimentation, increase soil health metrics, and of particular importance for the reduction of dead zones downstream, reduce agricultural nitrate pollution. Farmers can be paid to grow perennial species, but how much they are willing to accept to do so, as well as what factors influence the amount they want, are key. Using a mail survey administered to 3,000 farmers in Minnesota, home of the headwaters of the Mississippi, we show that farmers with a higher trust of environmental organizations and state agencies are willing to accept less to replace their crops with perennial crops, particularly for longer contracts, which produce more environmental benefits.
Genome‐wide re‐sequencing reveals population structure and genetic diversity of Bohai Black cattle
Authors: Liu Z. , Sun H. , Lai W. , Hu M. , Zhang Y. , Bai C. , Liu J. , Ren H. , Li F. , Yan S. 
Published: November 2021

SummaryBohai Black (BHB) cattle, one of eight representative indigenous breeds in China, is well known for its high resistance to disease, endurance under unfavorable feeding conditions and excellent meat quality. Over recent, the number of BHB cattle has decreased sharply. To investigate the population structure and genetic diversity of this breed, the whole‐genome data of 35 individuals from a conservation farm were obtained using the Illumina 150 bp paired‐end platform. The results of the genetic structure and diversity analyses showed that BHB cattle had mixed Bos taurus and Bos indicus ancestry, close phylogenic relationships with Jiaxian Red and Luxi cattle and abundant genetic diversity. The bulls tested here could be divided into six families. This study presents a comprehensive evaluation of the genetic structure and diversity of the BHB cattle, and lays the theoretical basis for conservation and utilization of the valuable germplasm resource.
A survey of ovarian reserve and quality of life in female survivors of pediatric cancer
Authors: Nilsson Sofia , Jarfelt Marianne , Järvholm Stina , Kluge Linda , Thurin‐Kjellberg Ann 
Published: November 2021

AbstractIntroductionChildhood cancer is rare; the incidence in Sweden is approximately 16 new cases/100 000 children each year. Reduced reproductive function and fertility are well‐known side effects of cancer treatment. Anti‐Müllerian hormone (AMH) has been shown to correlate well with antral follicle count in healthy women but is currently not recommended as the primary surveillance modality for evaluation of premature ovarian insufficiency in this patient group. Psychological wellbeing related to fertility could affect quality of life and should be included in long‐term follow‐up. The aim of the study is to present the baseline data from inclusion for a prospective follow‐up study of fertility surveillance where both medical and psychological aspects of fertility in female childhood cancer survivors are considered.Material and methodsThese are the first results from this longitudinal follow‐up cohort study. Female adolescent and young adult survivors of pediatric cancer in Western Sweden were included from January 2016 to December 2018, a total of 54 participants. Median age at inclusion was 21 (15–29) years and median age at cancer diagnosis was 10 (1–17) years. AMH levels, antral follicle count, and data on fertility were recorded at inclusion and will be prospectively followed up. The study includes questionnaires and interviews concerning quality of life. This study is planned to continue until the participants reach the age of 40 years.ResultsEighteen of 54 (33%) participants had AMH levels below 1.0 µg/L and were considered to have high or very high risk of infertility. Median AMH level was 2.50 µg/L. Six women had immediate need of oocyte cryopreservation. Psychological assessment showed that more than one‐third of participants (n = 20) had elevated anxiety scores.ConclusionsOne‐third of female survivors of pediatric cancer in the study had high risk of low ovarian reserve, measured by a combination of AMH and antral follicle count, and many had signs of anxiety. The longitudinal study could contribute to better knowledge in the changes of AMH over time for this patient group. Psychological follow‐up with questionnaires and interviews evaluating signs of depression and anxiety may serve as a model for future screening programs.
Prevalence of impaired kidney function in patients with long‐term lithium treatment: A systematic review and meta‐analysis
Authors: Schoretsanitis Georgios , de Filippis Renato , Brady Brian M. , Homan Philipp , Suppes Trisha , Kane John M. 
Published: November 2021

AbstractObjectivesAlthough lithium renal effects have been extensively investigated, prevalence rates of chronic kidney disease (CKD) in lithium‐treated patients vary. Our aim was to provide prevalence estimates and related moderators.MethodsWe performed a systematic review in PubMed/Embase until November 01, 2021, conducting a random effects meta‐analysis of studies evaluating CKD prevalence rates in lithium‐treated patients calculating overall prevalence ±95% confidence intervals (CIs). Meta‐regression analyses included sex, age, body mass index, smoking, hypertension, diabetes, cardiovascular disease, lithium‐treatment dose, duration, and blood levels. Subgroup analyses included sample size, diagnoses, and study design. Pooled odds ratios (OR) were estimated for studies including patients receiving nonlithium treatment. Study quality was assessed using the Newcastle–Ottawa scale.ResultsFive, nine, and six trials were rated as high, fair, and low quality, respectively. In 20 studies (n = 25,907 patients), we estimated an overall prevalence of 25.5% (95% CI = 19.8–32.2) of impaired kidney function; despite lack of differences (p = 0.18), prevalence rates were higher in elderly samples than mixed samples of elderly and nonelderly (35.6%, 95% CI = 21.4–52.9, k = 2, n = 3,161 vs. 25.1%, 95% CI = 19.1–31.3, k = 18, n = 22,746). Prevalence rates were associated with longer lithium treatment duration (p = 0.04). Cross‐sectional studies provided lower rates than retrospective studies (14.5%, 95% CI = 13.5–15.5, k = 6, n = 4,758 vs. 29.5%, 95% CI = 22.1–38.0, k = 12, n = 17,988, p < 0.001). Compared with 722,529 patients receiving nonlithium treatment, the OR of impaired kidney function in 14,187 lithium‐treated patients was 2.09 (95% CI = 1.24–3.51, k = 8, p = 0.005).ConclusionsOne‐fourth of patients receiving long‐term lithium may develop impaired kidney function, although research suffers from substantial heterogeneity between studies. This risk may be twofold higher compared with nonlithium treatment and may increase for a longer lithium treatment duration.
When is cultural input central? The development of ontological beliefs about religious and scientific unobservables
Authors: Davoodi Telli , Clegg Jennifer M. 
Published: November 2021

AbstractAcross diverse cultural contexts, children and adults believe in the existence of religious and supernatural unobservables (e.g., gods, angels) as well as scientific and natural unobservables (e.g., germs, oxygen). In this article, we explore the role of cultural input and testimony in children’s developing beliefs in supernatural and natural unobservables as real. We review cross‐cultural research with children and adults on their beliefs about the ontological status of religious and scientific unobservables and the epistemic patterns associated with these beliefs. Based on this evidence, we argue that cultural input plays a central role in the development of belief about supernatural unobservables as real, whereas it plays a less critical role in the development of belief about natural unobservables as real. In the latter case, we argue that direct experiences with the natural world combine with children’s naive theories to generate beliefs about natural unobservable entities and processes as real.
Early manifestations of intellectual performance: Evidence that genetic effects on later academic test performance are mediated through verbal performance in early childhood
Authors: Austerberry Chloe , Fearon Pasco , Ronald Angelica , Leve Leslie D. , Ganiban Jody M. , Natsuaki Misaki N. , Shaw Daniel S. , Neiderhiser Jenae M. , Reiss David 
Published: November 2021

AbstractIntellectual performance is highly heritable and robustly predicts lifelong health and success but the earliest manifestations of genetic effects on this asset are not well understood. This study examined whether early executive function (EF) or verbal performance mediate genetic influences on subsequent intellectual performance, in 561 U.S.‐based adoptees (57% male) and their birth and adoptive parents (70% and 92% White, 13% and 4% African American, 7% and 2% Latinx, respectively), administered measures in 2003–2017. Genetic influences on children's academic performance at 7 years were mediated by verbal performance at 4.5 years (β = .22, 95% CI [0.08, 0.35], p = .002) and not via EF, indicating that verbal performance is an early manifestation of genetic propensity for intellectual performance.
Oral sulfate solution versus low‐volume polyethylene glycol for bowel preparation: Meta‐analysis of randomized controlled trials
Authors: Ali Ijlal Akbar , Roton Daniel , Madhoun Mohammed 
Published: November 2021

Background and AimsOral sodium sulfate (OSS) solution and low‐volume polyethylene glycol‐based solutions are two of the more common low‐volume purgatives used as colonoscopy preparations. Data on how these different low‐volume solutions compare are mixed. Our aim was to conduct a meta‐analysis of randomized controlled trials (RCTs) to compare OSS with low‐volume polyethylene glycol solutions (PEG) plus ascorbic acid (PEG + Asc) solution with respect to (i) satisfactory bowel preparation, (ii) excellent bowel preparation, and (iii) tolerability.MethodsStudies were identified by searching 10 medical databases for reports published from 1974 until 2019. Only fully published RCTs comparing OSS and low‐volume PEG‐based products with regard to overall satisfactory bowel preparation were included. Pooling was conducted by both fixed‐effects and random effects models; results are presented from the random effects model when heterogeneity was significant.ResultsSeven studies (involving 2049 subjects) met the inclusion criteria. There was no difference between OSS and PEG + Asc with respect to adequate bowel preparation (risk ratio [RR] 1.02 [0.99–1.06]; P = 0.16). OSS did result in a higher chance of excellent bowel preparation (RR 1.18 [1.06–1.31]; P = 0.03). OSS was associated with a 30% increased risk of nausea (RR 1.35 [1.03–1.77]; P = 0.03) and more than double the risk of vomiting (RR 2.30 [1.63–2.23]; P < 0.05) compared with PEG + Asc. Begg's funnel plot indicated low probability of publication bias.ConclusionsIndividuals at low risk of inadequate bowel preparation who use OSS for bowel preparation are more likely to achieve excellent bowel preparation, but are more likely to experience nausea and vomiting than are individuals using low‐volume PEG‐based solutions.
Class I HDAC modulates angiotensin II–induced fibroblast migration and mitochondrial overactivity
Authors: Huynh Tin Van , Rethi Lekha , Chung Cheng‐Chih , Yeh Yung‐Hsin , Kao Yu‐Hsun , Chen Yi‐Jen 
Published: November 2021

AbstractBackgroundInhibition of histone deacetylases (HDACs) attenuates cardiac fibrosis. In this study, we evaluated whether the inhibition of class I HDACs can attenuate angiotensin II (ANG II)–induced fibrogenesis and mitochondrial malfunction through its effects on reactive oxygen species (ROS) and calcium dysregulation in human cardiac fibroblasts (CFs).MethodsSeahorse XF24 extracellular flux analyser, fluorescence staining, Western blotting, HDAC activity assays and Transwell migration assay were used to study mitochondrial respiration, adenosine triphosphate (ATP) production, mitochondrial calcium uptake and ROS, HDAC expression and activity and fibroblast activity in CFs without (control) or with ANG II (100 nM) and/or MS‐275 (HDAC class 1 inhibitor, 10 μM) for 24 h.ResultsANG II increased HDAC activity without changing protein expression in CFs. Compared with controls, ANG II‐treated CFs had greater migration activity, higher ATP production, maximal respiration and spare capacity with higher mitochondrial Ca2+ uptake and ROS generation, which was attenuated by the administration of MS‐275. ANG II activated CFs by increasing mitochondrial calcium content and ATP production, which may be caused by increased HDAC activity. Inhibition of HDAC1 attenuated the effects of ANG II by reducing mitochondrial ROS generation and calcium overload.ConclusionsModulating mitochondrial function by regulation of HDAC may be a novel strategy for controlling CF activity.