bluuebunny/crossref_metadata_2025_split huggingface dataset:
A force-sensitive adhesion GPCR is required for equilibrioception
Authors: Yang Zhao , Zhou Shu-Hua , Zhang Qi-Yue , Song Zhi-Chen , Liu Wen-Wen , Sun Yu , Wang Ming-Wei , Fu Xiao-Long , Zhu Kong-Kai , Guan Ying , Qi Jie-Yu , Wang Xiao-Hui , Sun Yu-Nan , Lu Yan , Ping Yu-Qi , Xi Yue-Tong , Teng Zhen-Xiao , Xu Lei , Xiao Peng , Xu Zhi-Gang , Xiong Wei , Qin Wei , Yang Wei , Yi Fan , Chai Ren-Jie , Yu Xiao , Sun Jin-Peng 
Published: February 2025

Abstract
Equilibrioception (sensing of balance) is essential for mammals to perceive and navigate the three-dimensional world. A rapid mechanoelectrical transduction (MET) response in vestibular hair cells is crucial for detecting position and motion. Here, we identify the G protein-coupled receptor (GPCR) LPHN2/ADGRL2, expressed on the apical membrane of utricular hair cells, as essential for maintaining normal balance. Loss of LPHN2 specifically in hair cells impaired both balance behavior and the MET response in mice. Functional analyses using hair-cell-specific Lphn2-knockout mice and an LPHN2-specific inhibitor suggest that LPHN2 regulates tip-link-independent MET currents at the apical surface of utricular hair cells. Mechanistic studies in a heterologous system show that LPHN2 converts force stimuli into increased open probability of transmembrane channel-like protein 1 (TMC1). LPHN2-mediated force sensation triggers glutamate release and calcium signaling in utricular hair cells. Importantly, reintroducing LPHN2 into the hair cells of Lphn2-deficient mice restores vestibular function and MET response. Our data reveal that a mechanosensitive GPCR is required for equilibrioception.
Comparative models of uveitis
Authors: Knutson Olivia S. , Choi Soyoung , Williams Simon , Calder Virginia L. 
Published: February 2025

Abstract
Several clinical subtypes of uveitis exist yet specific immunopathogenic mechanisms involved remain unclear. Ex vivo studies are limited by lack of fresh retinal biopsies and studies have relied on aqueous humour or peripheral blood, which may not directly reflect disease. The aim of this review is to compare the various in vivo models and review their contributions to our understanding of disease processes. These models, although unable to reflect all clinical signs, have provided insight into the contribution of genes and molecules, characterisation of effector T-cells, cell trafficking into retinal tissues, the contribution of tissue-resident myeloid cells and the mechanism(s) of action of several anti-inflammatory compounds. In vivo uveitis models have provided an excellent resource with which to study the molecular and cellular processes involved. Recent refinements in models, improved imaging, and the application of omics have greatly increased the number of readouts and translational opportunities. Future approaches with in vitro models will also be discussed.
How to improve functional outcome of inflatable penile implant surgery? a narrative review
Authors: Vural Ahmet , De Bruyn Helene , Van Renterghem Koenraad 
Published: February 2025

Abstract
The implantation of a three-piece inflatable penile prosthesis (IPP) has been shown to be a safe and successful treatment with a high satisfaction rate among individuals with erectile dysfunction. This narrative review aims to explore ways to improve the functional outcomes of IPP implantation. We conducted an English-language narrative review using all relevant articles sourced from PubMed. Over the years, modifications in IPP surgery have focused on increasing the longevity of prostheses and improving functional outcomes. These modifications include advancements in surgical methods, implant types, intracorporeal tubing length, the use of rear tip extenders, and reservoir placement. IPP implantation continues to significantly improve quality of life, making it essential for surgeons to stay updated on the latest developments and research to ensure the best outcomes for their patients. Optimal functional outcomes are achieved by an experienced surgical team and the use of a safe, rapid, minimally invasive surgical technique with the latest technology and equipment.
Data on the diet and nutrition of urban and rural bumblebees
Authors: Casanelles-Abella Joan , Selva Simonetta , Keller Alexander , Ruedenauer Fabian A. , Fournier Bertrand , Leonhardt Sara D. , Moretti Marco 
Published: February 2025

Abstract
Land-use changes, driven by agricultural intensification and urbanization, are major contributors to biodiversity loss, altering habitats and reducing available resources. These changes impact species’ foraging strategies, particularly in human-modified ecosystems. While dietary shifts due to land-use changes have been well-studied in vertebrates, similar research in invertebrates, such as wild bees, remains limited. The present data paper provides a comprehensive dataset on the pollen collected from urban and rural populations of two bumblebee species (Bombus lapidarius and B. pascuorum) in Switzerland, examining pollen composition, nutrient content, and diet breadth. Additionally, by analyzing pollen from both body and leg-baskets, the dataset also offers a comprehensive overview of plant-bumblebee interactions. The data help understand plant-bumblebee interactions, pollination services, nutritional supply to larvae, and the impact of land-use changes on these processes. Furthermore, the dataset can be integrated with existing plant trait data to explore the effects of non-native species and other ecological factors on bumblebee foraging and nutrition in anthropogenically modified landscapes.
Measuring social mobility in temporal networks
Authors: Barnes Matthew Russell , Nicosia Vincenzo , Clegg Richard G. 
Published: February 2025

Abstract
In complex networks, the “rich-get-richer” effect (nodes with high degree at one point in time gain more degree in their future) is commonly observed. In practice this is often studied on a static network snapshot, for example, a preferential attachment model assumed to explain the more highly connected nodes or a rich-club effect that analyses the most highly connected nodes. In this paper, we consider temporal measures of how success (measured here as node degree) propagates across time. By analogy with social mobility (a measure of people moving within a social hierarchy through their life) we define hierarchical mobility to measure how a node’s propensity to gain degree changes over time. We introduce an associated taxonomy of temporal correlation statistics including mobility, philanthropy and community. Mobility measures the extent to which a node’s degree gain in one time period predicts its degree gain in the next. Philanthropy and community measure similar properties related to node neighbourhood. We apply these statistics both to artificial models and to 26 real temporal networks. We find that most of our networks show a tendency for individual nodes and their neighbourhoods to remain in similar hierarchical positions over time, while most networks show low correlative effects between individuals and their neighbourhoods. Moreover, we show that the mobility taxonomy can discriminate between networks from different fields. We also generate artificial network models to gain intuition about the behaviour and expected range of the statistics. The artificial models show that the opposite of the “rich-get-richer” effect requires the existence of inequality of degree in a network. Overall, we show that measuring the hierarchical mobility of a temporal network is an invaluable resource for discovering its underlying structural dynamics.
A sensitive chalcogenide-based electrochemical sensor for ultra-level detection of Mospilan residues in real samples
Authors: Beheshti-Marnani Amirkhosro , Rohani Tahereh , kermani Mahdokht Arjmand , Mohammadi Sayed zia 
Published: February 2025

Abstract
Addressed herein, the synthetic bismuthinite and bismuthinite@copper sulphide as two metal chalcogenides have been applied for modifying a glassy carbon electrode(GCE). The as-prepared nanomaterials were characterized using X-ray diffraction (XRD), scanning electron microscopy(SEM) and Energy-dispersive X-ray spectroscopy(EDX). By comparing the results, bismuthinite @copper sulphide hybridized with graphene oxide (GO) modified electrode exhibited superior sensitivity for detection ultra-levels of pesticide Mospilan (acetamiprid) in real samples. The dynamic concentration range of acetamiprid was found to be 80-680nM with a remarkably low detection limit about 4.1nM along with good stability and repeatability. Finally, the fabricated electrochemical sensor, bismuthinite@copper sulphide/GO, was suggested as a suitable alternative to more complex enzyme-based and aptamer-based methods for Mospilan detection.
Combinatorial ab initio calculations and core spectroscopy unravel the electronic structure of nickel cobalt manganese oxide
Authors: Reents Timo , Kataev Elmar , Duarte-Ruiz Daniel , Wilks Regan G. , Garcia-Diez Raul , Bär Marcus , Cocchi Caterina 
Published: February 2025

Abstract
The rising interest in complex oxides for energy storage applications calls for the development of efficient computational schemes that enable exploring the vast configurational space of these materials to guide and complement experiments. In this work, we adopt a high-throughput screening method based on density-functional theory to investigate the electronic-structure fingerprints of a specific stoichiometry of lithiated manganese-cobalt-nickel oxide,
$$\hbox {LiNi}_{0.8}\hbox {Co}_{0.1}\hbox {Mn}_{0.1}\hbox {O}_{2}$$
, which are relevant for the identification of the material in X-ray spectroscopy experiments. After creating the candidate structures in an automated fashion, we inspect their structural characteristics and electronic properties focusing specifically on the Ni and O contributions to the density of states. To do so, we exploit data analysis schemes that provide us with a metric to classify the considered structures according to the properties of interest, including the oxidation state. Comparison with X-ray absorption spectroscopy measurements confirms the robustness of the developed computational approach and reveals the most likely composition of the probed sample.
A fuzzy system based self-adaptive memetic algorithm using population diversity control for evolutionary multi-objective optimization
Authors: Subburaj Brindha , Miruna Joe Amali S. 
Published: February 2025

Abstract
Simulated by nature’s evolution, numerous evolutionary algorithms had been proposed. These algorithms perform better for a particular problem domain and extensive parameter fine tuning and adaptations are required in optimizing problems of varied domain. This paper aims to develop robust and self-adaptive memetic algorithm by combining Differential Evolution based algorithm, a popular population based global search method with the Controlled Local search procedure to solve multi-objective optimization problems. Memetic Algorithm is an enhanced evolutionary algorithm, it combines global search method with local search techniques for faster convergence. Memetic algorithm improves both exploration and exploitation, preventing premature convergence and also refines the current best solutions efficiently. Proposed algorithm is named as Fuzzy based Memetic Algorithm using Diversity control (F-MAD). In F-MAD, population diversity is controlled through the control parameters self-adaptation of Differential Evolution algorithm (DE) such as, crossover rate and scaling factor by using two fuzzy systems. A controlled local search procedure is adapted for guiding convergence process thus balancing explore-exploit cycle. The control parameter self-adaptation and enhanced selection method with controlled local search method aid population diversity control in decision space and attaining optimal solutions with uniform distribution in terms of diversity and convergence metrics in objective space. These characteristics help the proposed method suitable to be extended to different application domain without the need of trial-and-error fine tuning of the parameters. The performance is tested through standard benchmark test problems-CEC 2009 test problems and DTLZ test problem and further validated through performance metrics and statistical test. It is compared with popular optimization algorithms and experiment results indicate that F-MAD perform well than State of-The-Art (SOTA) algorithms taken for comparison. F-MAD algorithm attains better results for 8 out of 10 CEC 2009 test problems (UF1-UF10) when compared to 20 other algorithms taken for comparison. For DTLZ problems, F-MAD attains better results for ALL 7 problems (DTLZ 1-DTLZ7) when compared to 8 other SOTA algorithms. The performance is further evaluated using Friedman rank test and the proposed F-MAD significantly outperformed other algorithms.
Symmetry-based analysis after surgical treatment of zygomaticomaxillary complex fractures using intraoperative cone-beam computed tomography: a retrospective case-control study
Authors: Franke Adrian , Matschke Jan Bernard , Bučkova Michaela , Rahrisch Lea , Lauer Günter , Leonhardt Henry 
Published: February 2025

Abstract
Zygomaticomaxillary fractures are among the most common fractures of the facial skeleton. Open reduction and internal fixation require radiographic control. Three-dimensional radiographs provide superior information on actual distances. The study aims to quantify and evaluate intraoperative reduction control by cone-beam computed tomography. The retrospective case-control study evaluates three-dimensional radiographs through linear measurements of defined skeletal landmarks from the median sagittal plane for symmetry. The study group received open reduction and internal fixation for zygomaticomaxillary fractures, and the control group consisted of a population without pathology of the midfacial region. The study group showed the same degree of symmetry as the control group. The mean absolute distance of all landmarks was 1.5 ± 1.3 mm in the study group and 1.0 ± 0.9 mm in the control group. There was a statistically significant likelihood of the right side being further away from the midline than the left. The study showed adequate reduction results of zygomaticomaxillary fractures. Moreover, the same degree of symmetry was ascertained compared to a control group. Intraoperative cone-beam computed tomography serves as a valid tool to check for immediate reduction control during surgery for zygomaticomaxillary fractures.
Structural Priming for Sentence Production in Aphasia: What Does Oral Repetition Do?
Authors: Lee Jiyeon , Man Grace , Christ Sharon , Zhang Peng 
Published: February 2025

Purpose:
Structural priming—speakers' unconscious tendency to reuse previously encountered sentence structures (primes) in future production—facilitates access and learning of grammatical representations in persons with aphasia (PWAs). However, it remains unclear which components of structural priming tasks are essential to consistent and lasting effects, a discovery critical for cost-effective clinical translation of research. We examined the effects of orally repeating versus listening to primes on immediate and lasting sentence production in PWAs and controls.

Method:
In a collaborative priming task, participants took turns with the experimenter, describing transitive and dative event pictures. One group of PWAs and controls listened to the experimenter's descriptions (primes) before they described their own picture, whereas the other group orally repeated their interlocutor's prime sentences before the target picture descriptions. In Experiment 1, the target picture description was elicited immediately after the prime (0-lag, immediate priming). In Experiment 2, two filler trials (2-lag) intervened between prime and target, examining longer term priming.

Results:
At both immediate and longer term priming, significant priming effects were observed in both groups, as indicated by increased productions of passives following passive versus active primes and increased productions of double-object dative sentences following double-object than prepositional object dative prime sentences. However, orally repeating prime sentences did not reliably and consistently enhance the magnitude of priming effects across lags and groups. Additionally, PWAs' repetition abilities did not result in higher degrees of priming effects.

Conclusion:
These findings suggest that opportunities for processing syntactic representations that shared between prior (prime) and current (target) utterances is a rather essential ingredient for positive structural priming in PWAs, while repeating prime sentences is an optional ingredient that can be removed or modified.

Supplemental Material:

https://doi.org/10.23641/asha.28291949
Small-Dose Behavioral Treatment Effects: Learning Following 2 Hours of Computer-Based Conversational Script Training in Individuals With Poststroke Aphasia
Authors: Braun Emily J. , Cherney Leora R. 
Published: February 2025

Purpose:
Optimal dosage parameters are underspecified for aphasia therapy. This study evaluated effects of small doses of conversational script training in individuals with chronic poststroke aphasia.

Method:
Ten adults with chronic poststroke aphasia completed 2 hr of computerized conversational script training on two consecutive days via AphasiaScripts. Accuracy and rate of production of a trained and an untrained conversational script were probed at three baseline timepoints and various timepoints after the first and second treatment sessions up to 2 weeks posttreatment. Generalization in accuracy of trained script production was evaluated through a live conversational interaction. Mixed-effects linear regression models evaluated changes in accuracy and rate of script production across timepoints.

Results:
Participants showed significantly improved accuracy and rate of trained script production immediately following 1 and 2 hr of treatment. Gains in script production accuracy and rate were maintained up to 1 week posttreatment. Generalization probe production accuracy improved significantly from baseline to immediately posttreatment and 2 weeks posttreatment.

Conclusions:
Improvement in production of trained conversational scripts following 1 and 2 hr of treatment can be documented in individuals with poststroke aphasia. These results provide estimates for the effects of 1 and 2 hr of conversational script training that can be used in future dosage manipulations.

Supplemental Material:

https://doi.org/10.23641/asha.28339925
Deep regression 2D‐3D ultrasound registration for liver motion correction in focal tumour thermal ablation
Authors: Xing Shuwei , Cool Derek W. , Tessier David , Chen Elvis C. S. , Peters Terry M. , Fenster Aaron 
Published: February 2025

AbstractLiver tumour ablation procedures require accurate placement of the needle applicator at the tumour centroid. The lower‐cost and real‐time nature of ultrasound (US) has advantages over computed tomography for applicator guidance, however, in some patients, liver tumours may be occult on US and tumour mimics can make lesion identification challenging. Image registration techniques can aid in interpreting anatomical details and identifying tumours, but their clinical application has been hindered by the tradeoff between alignment accuracy and runtime performance, particularly when compensating for liver motion due to patient breathing or movement. Therefore, we propose a 2D–3D US registration approach to enable intra‐procedural alignment that mitigates errors caused by liver motion. Specifically, our approach can correlate imbalanced 2D and 3D US image features and use continuous 6D rotation representations to enhance the model's training stability. The dataset was divided into 2388, 196, and 193 image pairs for training, validation and testing, respectively. Our approach achieved a mean Euclidean distance error of and a mean geodesic angular error of , with a runtime of per 2D–3D US image pair. These results demonstrate that our approach can achieve accurate alignment and clinically acceptable runtime, indicating potential for clinical translation.
Therapiekonzepte sowie Prävention/Überwindung von Resistenzen
Authors: Kretzschmar Alexander 
Published: February 2025

ZusammenfassungDas Anfang der 1980er Jahre entdeckte KRAS (Kirsten Rat Sarcoma) ist derzeit das bekannteste Onkogen mit der höchsten Mutationsrate bei zahlreichen Tumorentitäten, insbesondere beim Pankreaskarzinom, dem nicht-kleinzelligen Lungenkarzinom (NSCLC) und dem kolorektalen Karzinom (CRC). Auf der 36. Jahrestagung des EORTC-NCI-AACR Symposiums on Molecular Targets and Cancer Therapeutics (ENA 24) diskutierten Forschende über aktuelle Konzepte zur Therapie KRAS/RAS-mutierter Karzinome sowie zur Prävention und Überwindung von Resistenzen.
Die Entwicklung der Atmungstherapeuten in Deutschland – Eine Analyse der aktuellen Weiterbildungs- und Arbeitssituation von Atmungstherapeuten
Authors: Flügge Dennis , Held Matthias 
Published: February 2025

ZusammenfassungObwohl die Weiterbildung zum Atmungstherapeuten seit über 18 Jahren in Deutschland existiert, gibt es kaum repräsentative Erhebungen zu diesem Tätigkeitsfeld. In dieser Studie sollte herausgefunden werden, welche Berufsgruppen sich von der Weiterbildung angesprochen fühlen, wie zufrieden sie mit der Weiterbildung waren und wo die AT eingesetzt werden. Zudem wird ein Blick darauf geworfen, wie sich die Arbeitsbedingungen nach der Weiterbildung ausgestalten und wie die Zusammenarbeit mit anderen Berufsgruppen funktioniert. Weiter sollte kontrolliert werden, ob es Faktoren gibt, die auf die o.g. Punkte Einfluss haben. Der letzte Aspekt gibt einen Ausblick darauf, wie sich die Atmungstherapie in Deutschland voraussichtlich in Zukunft entwickelt und was für ihre zukünftige Entwicklung wichtig ist.In einer quantitativen Querschnittsstudie wurde eine teilanonymisierte elektronische Befragung unter angehenden und weitergebildeten Atmungstherapeuten in Deutschland durchgeführt. Die Auswertung der Umfrage wurde zum einen über das (browserbasierte) Programm „Online Umfrage.com“ und zum anderen über das Tabellenkalkulationsprogramm Microsoft Excel durchgeführt. Die Analyse der offenen Fragen wurde mittels der qualitativen Inhaltsanalyse nach Mayring durchgeführt.An der Befragung nahmen 307 angehende und weitergebildete Atmungstherapeuten aus allen Bundesländern und Weiterbildungsjahrgängen teil. Die meisten der Befragten waren im klinischen Bereich tätig. 90% der Befragten waren mit der Weiterbildung eher oder sogar sehr zufrieden. Sie waren zu einem Viertel gar nicht oder nur z.T. für ihre Tätigkeit freigestellt. Die Hälfte der Befragten hat sich nach der Weiterbildung finanziell nicht verbessern können. Dennoch würden 81,25% der Atmungstherapeuten die Weiterbildung weiterempfehlen. Bei der Frage, was für die Zukunft wichtig sei, waren die Antworten vielseitig und reichten von staatlicher Anerkennung über bessere Zusammenarbeit der Weiterbildungsanbieter bis zur besseren Öffentlichkeitsarbeit.Die Weiterbildung zum Atmungstherapeuten wird als sehr positiv angesehen. Jedoch zeigen sich bei den Themen Vergütung, Freistellung und Weiterbildungsentwicklung noch wesentliche Probleme. Als einer der wichtigsten Einflussfaktoren wurde die Art des Vorgesetzten herausgearbeitet. So sahen sich Atmungstherapeuten, die dem ärztlichen Dienst anstelle der Pflegedienstleitung unterstellt waren, deutlich zufriedener.