bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized controlled trial comparing the efficacy, tolerability, and cost of oral iron preparations in iron‐deficiency anemia in pregnancy
Authors: Gamad Nanda , Saha Pradip Kumar , Sharma Prashant , Suri Vanita , Chakrabarti Amitava , Saha Lekha 
Published: September 2021

AbstractObjectiveTo evaluate the efficacy, tolerability, and cost of four commonly prescribed oral iron preparations: ferrous sulfate (FS), ferrous fumarate (FF), ferrous ascorbate (FA), and carbonyl iron (CI) in the treatment of iron‐deficiency anemia (IDA) in pregnant women.MethodsIt was a prospective, randomized, open‐label, blinded endpoint (PROBE) design with four parallel active control groups: FS, FF, FA, CI. The primary outcome was the proportion of participants becoming non‐anemic (Hb ≥ 11 g%) at the end of the study period. The secondary outcomes were the proportion of participants achieving normal red blood corpuscular indices such as mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration; the proportion of participants achieving normal iron indices such as serum iron, serum ferritin, total iron‐binding capacity, and transferrin saturation; and comparison of incidence of any adverse events between treatment groups and comparison of costs of individual drug therapy between treatment groups.ResultsOne hundred and twenty patients were randomized to four different groups (n = 30). The results of the present study show that all the four iron salts at the dose of 200 mg elemental iron per day were equally effective in improving hemoglobin concentration and other hematological parameters. The adverse effects were more common in the FF group (56.7%). The pharmacoeconomic analysis showed that all the drugs are equally cost‐effective.ConclusionTo conclude from the results of the present study, it can be said that FS, FF, FA, and CI are equally effective in treating IDA and they can be prescribed interchangeably.
Attitude changes toward prenatal testing among women with twin pregnancies after the introduction of noninvasive prenatal testing: A single‐center study in Japan
Authors: Ogawa Masanobu , Hasuo Yasuyuki , Taura Yumiko , Tsunematsu Ryosuke , Shikada Sawako , Matsushita Yuki , Sato Kazuo 
Published: September 2021

AbstractAimThis study aimed to evaluate changes in prenatal testing among women with twin pregnancies before and after the introduction of noninvasive prenatal testing (NIPT). To date, no consensus on prenatal testing for twin pregnancies has been reached in Japan.MethodsWomen pregnant with twins who requested prenatal testing at Kyushu Medical Center from 2005 to 2018 were included in this study. Genetic counseling was provided to all participants. Their chosen methods of testing were collected and classified as invasive diagnosis (ID), noninvasive screening (NIS), and no test requested (NR). Parity, chorionicity, and methods of conception were assessed as attributes. The study period was divided into three terms according to testing availability in our center.ResultsAfter NIPT was introduced in our center, the use of ID methods decreased and eventually disappeared while NIS came to the forefront. NR was also the preferred choice of women with twin pregnancies before the introduction of NIPT and decreased but did not disappear after introducing NIPT. Women with twin pregnancies who underwent assisted reproduction initially showed hesitation to undergo testing but showed a strong preference for NIS after the introduction of NIPT. Differences in choice according to parity, chorionicity, and methods of conception were found before the introduction of NIPT but disappeared after introducing NIPT.ConclusionIncreasing information about NIPT has apparently influenced the attitudes of women with twin pregnancies to prenatal testing in Japan. In particular, those who conceive through assisted reproductive technologies exhibited a strong preference for NIPT.
Sleep and circadian rhythm characteristics in individuals from the general population during the French COVID‐19 full lockdown
Authors: Bertrand Léa , Schröder Carmen , Bourgin Patrice , Maruani Julia , Atoui Yasmine , d’Ortho Marie‐Pia , Lejoyeux Michel , Geoffroy Pierre A. 
Published: September 2021

SummaryThe full 2‐month lockdown to fight the coronavirus disease 2019 (COVID‐19) pandemic in 2020 led to substantial disruption of daily life and routines. The present study aimed to comprehensively identify the lockdown’s effects on sleep, daily rhythms and emotions of the French population. A survey was published online during the last week of the 2‐month full lockdown and 1,627 individuals completed the online survey. The survey was self‐administered and included standardised questionnaires. Sleep schedules were delayed during lockdown in more than half of the participants. New severe delayed sleep phase affected 10% of participants with sleep schedules delayed by ≥3 hr during the lockdown compared to before. A significant decrease in exposure to morning (p < 0.001) and evening natural light (p < 0.001), a significant increase in screen exposure time (with a significant screen exposure >3 hr during the evening for 45% of the participants during lockdown versus 18% before lockdown, p < 0.001), an increase in substance use for one‐quarter of participants, a poorer sleep quality in 56% of participants, and less regular sleep schedules in 48% of participants were observed. We also found a poorer sleep quality in women than men during lockdown (p = 0.004). The French full lockdown had a severe impact on sleep quality, sleep–wake rhythms, and sleep behaviours. The implementation of public health strategies for the prevention and care of sleep–wake cycles during lockdown are therefore essential.
Autistic autobiography and hermeneutical injustice
Authors: Dinishak Janette 
Published: September 2021

AbstractThis paper examines epistemic injustice in knowledge production concerning autism. Its aim is to further our understanding of the distinctive shapes of the kinds of epistemic injustices against autists. The paper shows how Ian Hacking’s work on autistic autobiography brings into view a form of hermeneutical injustice that autists endure with respect to their firsthand accounts of their experiences of autism. It explores how understanding the distinctive shape of this hermeneutical injustice can help us further appreciate dangers and harms of using interpretive frameworks for autistic experience that neglect autists’ own contributions to the formation of words and concepts for capturing their experiences. In particular, the paper argues that even when autists are included in knowledge production concerning autistic experience, they remain vulnerable to forms of hermeneutical marginalization that can stifle the coming into being of autistic experience.
Arbitrariness and Uniqueness
Authors: Meacham Christopher J. G. 
Published: September 2021

AbstractEvidential Uniquenessis the thesis that, for any batch of evidence, there's a unique doxastic state that a subject with that evidence should have. One of the most common kinds of objections to views that violate Evidential Uniqueness are arbitrariness objections – objections to the effect that views that do not satisfy Evidential Uniqueness lead to unacceptable arbitrariness. The goal of this paper is to examine a variety of arbitrariness objections that have appeared in the literature, and to assess the extent to which these objections bolster the case for Evidential Uniqueness. After examining a number of different arbitrariness objections, I'll conclude that, by and large, these objections do little to bolster the case for Evidential Uniqueness.
A Burning Concern: Family Forest Owner Wildfire Concerns Across Regions, Scales, and Owner Characteristics
Authors: Danley Brian , Caputo Jesse , Butler Brett J. 
Published: September 2021

AbstractWhile there is a large literature on how individual homeowners perceive location‐specific wildfire hazard, there is only one study specific to U.S. family forest owners. Using respondents from the United States Department of Agriculture (USDA) Forest Service's National Woodland Owner Survey of family forest ownerships in the United States, we investigate the relationship between landowners’ wildfire concerns and biophysical wildfire hazard across the contiguous United States. As a measure of long‐term conditions for high intensity wildfire, we use the USDA Forest Service's Wildfire Hazard Potential Index as our key variable of interest. We test six ways of aggregating Wildfire Hazard Potential using 1‐, 10‐, and 100‐mile (1.6, 16, and 160 km) radii buffers with linear and logistic specifications for hazard potential. Results show the log of Wildfire Hazard Potential is the best fit for modeling wildfire hazard concerns. Respondents in the western United States have a higher baseline level of concern but are not necessarily more sensitive to the hazard spectrum compared to respondents in the north. Respondents in the southern United States have a lower sensitivity to the hazard spectrum compared to respondents in the north and west. Using predicted probabilities at the means, we also compute regional prevalence ratios to compare the impact of biophysical wildfire hazard to the relative impact of other important variables. Various property and owner characteristics not related to biophysical hazard potential, such as emotion, receiving information about wildfire, and the presence of a house on the property are determinants of wildfire concern in some, but not all regions of the United States.
Ideology Critique: A Deleuzian Case
Authors: Oh Keunchang 
Published: September 2021

AbstractIt is well‐known that Gilles Deleuze (and Félix Guattari) are critical of the notion of ideology. However, it is not very clear why they seem to be so dismissive of it. In what follows, I will begin my discussion by showing what Deleuze means by ideology and reconstructing why Deleuze thinks that ideology is a misused concept and that the misuse of the concept warrants its dismissal. In Anti‐Oedipus, the insufficiency or inadequacy of the concept of ideology can be understood in light of the opposition between production and representation. Next, I will show that—in A Thousand Plateaus—this very opposition between production and representation is relaxed in favor of the notion of assemblage. By looking at Althusser’s theory of ideology, I will argue that ideology is not merely a cognitive representation in the sense that it can be considered as having its own material existence. If so, the concept of ideology does not have to be too narrowly conceived. Rather, I propose that Deleuze and Guattari offer a different kind of ideology critique through noology and the critical analysis of microfascism. Finally, I will conclude by arguing that Deleuze is still enacting a novel form of ideology critique despite his dismissal of the very terminology.
Voting in a global pandemic: Assessing dueling influences of Covid‐19 on turnout
Authors: Constantino Sara M. , Cooperman Alicia D. , Moreira Thiago M. Q. 
Published: September 2021

AbstractObjectiveWe investigate the impact of a global health crisis on political behavior. Specifically, we assess the impact of Covid‐19 incidence rates, and the impact of temporal and spatial proximity to the crisis, on voter turnout in the 2020 Brazilian municipal elections.MethodsWe use Ordinary Least Squares and Spatial Durbin Error models to evaluate sub‐national variation in municipal‐level Covid‐19 incidence and voter turnout. We include controls for political, economic, health, and state context.ResultsCeteris paribus, increasing deaths in the month leading up to the election from 0.01 to 1 per 1000 people is associated with a 5 percentage point decrease in turnout; higher cases and deaths earlier in the pandemic are generally associated with higher turnout. Covid‐19 incidence rates in nearby municipalities affect local turnout in the same directions.ConclusionHigher Covid‐19 incidence near the time of the election decreases voter turnout, while incidence farther from the election increases voter turnout.
Identification and characteristics of a novel gland‐forming gene in cotton
Authors: Zang Yihao , Xu Chenyu , Xuan Lisha , Ding Lingyun , Zhu JianKun , Si Zhanfeng , Zhang Tianzhen , Hu Yan 
Published: September 2021

SUMMARYThe cotton (Gossypium hirsutum) pigment gland is a distinctive structure that functions as the main deposit organ of gossypol and its derivatives. It is also an ideal system in which to study cell differentiation and organogenesis. However, only a few genes that determine the process of gland formation have been reported, including GoPGF, CGP1, and CGFs; the molecular mechanisms underlying gland initiation are still largely unclear. Here, we report the discovery of the novel stem pigment gland‐forming gene GoSPGF by map‐based cloning; annotated as a GRAS transcription factor, this gene is responsible for the glandless trait specifically on the stem. In the stem glandless mutant T582, a point mutation (C to A) was found to create a premature stop codon and truncate the protein. Similarly, virus‐induced gene silencing of GoSPGF resulted in glandless stems and dramatically reduced gossypol content. Comparative transcriptomic data showed that loss of GoSPGF significantly suppressed expression of many genes involved in gossypol biosynthesis and altered expression of genes involved in gibberellic acid signaling/biosynthesis. Overall, these findings provide more insight into the networks regulating glandular structure differentiation and formation in cotton, which will be helpful for understanding other plants bearing special gland structures such as tobacco (Nicotiana benthamiana), artemisia annua, mint (Mentha spp.), and rubber (Hevea brasiliensis).
What do multinationals do? The structure of multinational firms’ international activities
Authors: Davies Ronald B. , Markusen James R. 
Published: September 2021

AbstractAnalyses of multinational enterprises have generally shifted from a capital‐market perspective to viewing them as real production units. Yet, we still have difficulties in answering a basic question: What do multinational enterprises do? Here, we seek some broad, general answers about the structure of multinational firms’ international activities. By structure, we include (a) the geographic distribution of a firm's activities, (b) activities performed by various branches, (c) where do foreign affiliates sell their outputs and purchase their inputs and (d) interactions among establishments. Much of our analysis relates to which of two archetypes is dominant: (1) horizontal structures in which foreign affiliates replicate the firm's core activities and serve local and regional markets and (2) vertical structures in which foreign affiliates perform different activities and act as links in a global production chain. Examining this from a variety of perspectives, we find that horizontal replication dominates vertical fragmentation. The final section of the paper discusses intangible assets and other service flows between parents and affiliates. Smoking‐gun evidence suggests that these are large, particularly compared to intra‐firm trade in goods. Despite this, their importance is undervalued, likely due to severe measurement difficulties.
Evaluation and management of COVID-19-related severity in people with type 2 diabetes
Authors: Wang Bowen , Glicksberg Benjamin S , Nadkarni Girish N , Vashishth Deepak 
Published: September 2021

IntroductionPeople with type 2 diabetes (T2D) have an increased rate of hospitalization and mortality related to COVID-19. To identify ahead of time those who are at risk of developing severe diseases and potentially in need of intensive care, we investigated the independent associations between longitudinal glycated hemoglobin (HbA1c), the impact of common medications (metformin, insulin, ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and corticosteroids) and COVID-19 severity in people with T2D.Research design and methodsRetrospective cohort study was conducted using deidentified claims and electronic health record data from the OptumLabs Data Warehouse across the USA between January 2017 and November 2020, including 16 504 individuals with T2D and COVID-19. A univariate model and a multivariate model were applied to evaluate the association between 2 and 3-year HbA1c average, medication use between COVID-19 diagnosis and intensive care unit admission (if applicable), and risk of intensive care related to COVID-19.ResultsWith covariates adjusted, the HR of longitudinal HbA1c for risk of intensive care was 1.12 (per 1% increase, p<0.001) and 1.48 (comparing group with poor (HbA1c ≥9%) and adequate glycemic control (HbA1c 6%–9%), p<0.001). The use of corticosteroids and the combined use of insulin and metformin were associated with significant reduction of intensive care risk, while ACEIs and ARBs were not associated with reduced risk of intensive care.ConclusionsTwo to three-year longitudinal glycemic level is independently associated with COVID-19-related severity in people with T2D. Here, we present a potential method to use HbA1c history, which presented a stronger association with COVID-19 severity than single-point HbA1c, to identify in advance those more at risk of intensive care due to COVID-19 in the T2D population. The combined use of metformin and insulin and the use of corticosteroids might be significant to prevent patients with T2D from becoming critically ill from COVID-19.
Effectiveness of at-home skin temperature monitoring in reducing the incidence of foot ulcer recurrence in people with diabetes: a multicenter randomized controlled trial (DIATEMP)
Authors: Bus Sicco A , aan de Stegge Wouter B , van Baal Jeff G , Busch-Westbroek Tessa E , Nollet Frans , van Netten Jaap J 
Published: September 2021

IntroductionThe skin of people with diabetic foot disease is thought to heat up from ambulatory activity before it breaks down into ulceration. This allows for early recognition of imminent ulcers. We assessed whether at-home monitoring of plantar foot skin temperature can help prevent ulcer recurrence in diabetes.Research design and methodsIn this parallel-group outcome-assessor-blinded multicenter randomized controlled trial (7 hospitals, 4 podiatry practices), we randomly assigned people with diabetes, neuropathy, foot ulcer history (<4 years, n=295), or Charcot’s neuro-arthropathy (n=9) to usual care (ie, podiatric treatment, education, and therapeutic footwear) or usual care plus measuring skin temperatures at 6–8 plantar sites per foot each day (enhanced therapy). If ∆T>2.2°C between corresponding sites on the left and right foot for two consecutive days, participants were instructed to reduce ambulatory activity until this hotspot disappeared and contact their podiatrist. Primary outcome was ulcer recurrence in 18 months on the plantar foot, interdigital, or medial/lateral/anterior forefoot surfaces; secondary outcome was ulcer recurrence at any foot site.ResultsOn the basis of intention-to-treat, 44 of 151 (29.1%) participants in enhanced therapy and 57 of 153 (37.3%) in usual care had ulcer recurrence at a primary outcome site (RR: 0.782 (95%CI 0.566 to 1.080), p=0.133). Of the 83 participants in enhanced therapy who measured a hotspot, the 24 subsequently reducing their ambulatory activity had significantly fewer ulcer recurrences (n=3) than those in usual care (RR: 0.336 (95% CI 0.114 to 0.986), p=0.017). Enhanced therapy was effective over usual care for ulcer recurrence at any foot site (RR: 0.760 (95% CI 0.579 to 0.997), p=0.046).ConclusionsAt-home foot temperature monitoring does not significantly reduce incidence of diabetic foot ulcer recurrence at or adjacent to measurement sites over usual care, unless participants reduce ambulatory activity when hotspots are found, or when aiming to prevent ulcers at any foot site.Trial registration numberNTR5403.
Premature ventricular complexes and development of heart failure in a community-based population
Authors: Limpitikul Worawan B , Dewland Thomas A , Vittinghoff Eric , Soliman Elsayed , Nah Gregory , Fang Christina , Siscovick David S , Psaty Bruce M , Sotoodehnia Nona , Heckbert Susan , Stein Phyllis K , Gottdiener John , Hu Xiao , Hempfling Ralf , Marcus Gregory M 
Published: September 2021

ObjectiveA higher premature ventricular complex (PVC) frequency is associated with incident congestive heart failure (CHF) and death. While certain PVC characteristics may contribute to that risk, the current literature stems from patients in medical settings and is therefore prone to referral bias. This study aims to identify PVC characteristics associated with incident CHF in a community-based setting.MethodsThe Cardiovascular Health Study is a cohort of community-dwelling individuals who underwent prospective evaluation and follow-up. We analysed 24-hour Holter data to assess PVC characteristics and used multivariable logistic and Cox proportional hazards models to identify predictors of a left ventricular ejection fraction (LVEF) decline and incident CHF, respectively.ResultsOf 871 analysed participants, 316 participants exhibited at least 10 PVCs during the 24-hour recording. For participants with PVCs, the average age was 72±5 years, 41% were women and 93% were white. Over a median follow-up of 11 years, 34% developed CHF. After adjusting for demographics, cardiovascular comorbidities, antiarrhythmic drug use and PVC frequency, a greater heterogeneity of the PVC coupling interval was associated with an increased risk of LVEF decline and incident CHF. Of note, neither PVC duration nor coupling interval duration exhibited a statistically significant relationship with either outcome.ConclusionsIn this first community-based study to identify Holter-based features of PVCs that are associated with LVEF reduction and incident CHF, the fact that coupling interval heterogeneity was an independent risk factor suggests that the mechanism of PVC generation may influence the risk of heart failure.