bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma
Authors: Ma Xiaolu , Zhou Kaixia , Yan Tianqing , Hu Ling , Xie Suhong , Zheng Hui , Tong Ying , Zhang Heng , Wang Yanchun , Gong Zhiyun , Chen Cuncun , Tian Yanan , Guo Lin , Lu Renquan 
Published: December 2024

AbstractLenvatinib, an approved first-line regimen, has been widely applied in hepatocellular carcinoma (HCC). However, clinical response towards Lenvatinib was limited, emphasizing the importance of understanding the underlying mechanism of its resistance. Herein, we employed integrated bioinformatic analysis to identify calpain-2 (CAPN2) as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples. Further in vitro and in vivo experiments indicated that knocking down CAPN2 greatly sensitized HCC cells to Lenvatinib treatment, while overexpression of CAPN2 achieved opposite effects in a Lenvatinib-sensitive HCC cell line. Interestingly, we observed a close relationship between CAPN2 expression and cancer stem cell (CSC) traits in HCC cells, evidenced by impaired sphere-forming and CSC-related marker expressions after CAPN2 knockdown, and verse vice. Mechanistically, we strikingly discovered that CAPN2 exerted its function by both enzyme-dependent and enzyme-independent manner simultaneously: activating β-Catenin signaling through its enzyme activity, and preventing GLI1/GLI2 degradation through direct binding to YWHAE in an enzyme-independent manner, which disrupting the association between YWHAE and GLI1/GLI2 to inhibit YWHAE-induced degradation of GLIs. Notably, further co-immunoprecipitation assays revealed that YWHAE could promote the protein stability of CAPN2 via recruiting a deubiquitinase COPS5 to prevent ubiquitination-induced degradation of CAPN2. In summary, our data demonstrated that CAPN2 promoted Lenvatinib resistance via both catalytic activity-dependent and -independent approaches. Reducing CAPN2 protein rather than inhibiting its activity might be a promising strategy to improve Lenvatinib treatment efficiency in HCC.
Congenital Hypogonadotropic Hypogonadism With Novel Pathogenic Variants in FGFR1 and GNRHR
Authors: Yamamoto Shinta , Nakajima Hanako , Okada Hiroshi , Nakanishi Naoko , Hamaguchi Masahide , Fukui Michiaki 
Published: December 2024

Abstract
Congenital hypogonadotropic hypogonadism (CHH) can cause delayed secondary sexual characteristics and contribute to juvenile osteoporosis, with multiple causative genes having been reported. We treated a 27-year-old man diagnosed with central hypogonadism, presenting with delayed secondary sexual characteristics and juvenile osteoporosis, using bone resorption inhibitors and testosterone therapy. Genetic testing revealed missense variants both in the fibroblast growth factor receptor 1 (FGFR1) and gonadotropin-releasing hormone receptor (GNRHR) genes, a combination that has not been previously reported. This case represents a CHH caused by a novel combination of gene variants not registered in the human genome mutation database.
Assessing clinical and morphological features of megalotrichosis induced by Tyrosine kinase inhibitors versus Prostaglandins analogues
Authors: Gershon Rotem , Vishnevskia-Dai Vicktoria 
Published: December 2024

Purpose
Describing the features of Megalotrichosis (MT) induced by Tyrosine kinase inhibitors (TKI) and differentiate it from Prostaglandins (PGs)–induced MT.

Methods
Medical data of patients with MT referred to our center between 2012–2021 were retrieved for: demographic parameters, medical, surgical and oncologic background, and ophthalmologic background along with diagnoses and treatment. Time from PGs/TKI introduction to MT presentation, MT clinical characteristics, associated complaints, and prescribed therapies in relevant cases were also documented. Ophthalmologic exam, ocular photography and data retrieved from medical records were used to assess MT features among the two groups. Morphological evaluation included number of upper (UL) and lower lid (LL) eyelash rows, poliosis, individual elongated eyelash and eyelash curvature. Masked evaluation of all the patients was performed.

Results
We found 11 patients, of which 6 treated with PGs for glaucoma and 5 treated with TKIs for non-ocular cancer suspected of dissemination. TKIs-induced MT was characterized by more individual elongated eyelashes (p = .047), UL eyelash rows (p = .03) and eyelash curvature (p = .076); poliosis characterized PGs-induced MT (p = .076). MT-associated complaints were more frequent in TKIs-induced MT (p = .06). time from drug administration to MT onset was shorter with TKI compared to PGs (median 176 Vs. 440 days, p = .257).

Conclusions
The study suggests that TKI-induced MT presents faster than PGs-induced MT and might be more bothering to patients. Knowledge of the morphological and clinical features that characterize each form of MT might be beneficial for patients and guide clinicians for intervention when needed. Larger cohorts are needed to reproduce and clarify our findings.
Bootlegging the Airwaves: Alternatives Histories of Radio and Television Distribution, Eleanor Patterson (2024)
Authors: Gallego J. Ignacio 
Published: December 2024

Review of: Bootlegging the Airwaves: Alternatives Histories of Radio and Television Distribution, Eleanor Patterson (2024)
Urbana, IL: University of Illinois Press, 192 pp.,
ISBN 978-0-25208-769-1, p/bk, $28.00
Risk of Cancer and Reoperation After Ileorectal Anastomosis and Ileal Pouch-Anal Anastomosis in Familial Adenomatous Polyposis
Authors: Bouchiba Hicham , Aelvoet Arthur S. , Pellisé Maria , Bastiaansen Barbara A.J. , van Leerdam Monique E. , Langers Alexandra M.J. , Balaguer Francesc , Miedema Thymen N. , Anele Chukwuemeka C. , Daca-Alvarez Maria , Bossuyt Patrick M.M. , Ricciardiello Luigi , Jover Rodrigo , Hompes Roel , Karstensen John G. , Latchford Andrew , Dekker Evelien ,   the European FAP Consortium
Published: December 2024

INTRODUCTION:
To prevent colorectal cancer, most patients with familial adenomatous polyposis (FAP) undergo (procto)colectomy with ileorectal anastomosis (IRA) or ileal pouch-anal anastomosis (IPAA). After surgery, these patients remain at risk of developing cancer in the remnant rectum or rectal cuff/pouch. We aimed to compare the long-term risk of cancer after IRA or IPAA in FAP.

METHODS:
We performed an international multicenter historical cohort study of FAP patients undergoing IRA or IPAA from 1990 to 2023. The proportion of patients developing cancer after surgery was estimated using the Kaplan-Meier method.

RESULTS:
(Procto)colectomy was performed in 685 patients (53.6% female); 366 (53.4%) had IRA, and 319 (46.6%) had IPAA. Median age at IRA and IPAA was 23 and 27 years, and the median follow-up was 12 and 15 years, respectively. Overall, 8 patients (2.2%) developed rectal and/or rectal cuff/pouch cancer after IRA and 0.9% after IPAA. The estimated 10- and 20-year cancer incidence after IRA vs IPAA was 1.6% vs 0.4% and 2.5% vs 0.9%, respectively (log-rank P = 0.15). Reoperations, mainly for extensive polyposis, were performed in 39 (10.7%) patients with an IRA and 24 (7.5%) patients after IPAA. The number of postoperative endoscopic surveillance endoscopies was higher in patients with an IRA compared with those with an IPAA (P < 0.001).

DISCUSSION:
Over the past 3 decades, few patients were diagnosed with cancer in the rectum or rectal cuff/pouch after (procto)colectomy in FAP. This might be due to an improved selection of the type of (procto)colectomy and close endoscopic surveillance including prophylactic polypectomies.
Multitarget Stool DNA Testing for Colorectal Cancer Screening in Clinical Practice
Authors: Jiang Linda , Yang Keming , Saul Melissa , Vajravelu Ravy K. , Schoen Robert E. 
Published: December 2024

INTRODUCTION:
Few studies have evaluated multitarget stool DNA (mt-sDNA) in clinical practice. We analyzed mt-sDNA utilization at the University of Pittsburgh Medical Center.

METHODS:
We assessed mt-sDNA orders between January 1, 2017, and December 31, 2021. Data collection included electronic capture of mt-sDNA orders, completed stool submissions, and test results. Multivariable models were used to assess associations between mt-sDNA completion and results and age, sex, and race.

RESULTS:
There were 91,664 mt-sDNA orders in 73,704 patients. A total of 54.7% (40,337/73,704) completed an mt-sDNA test, and 7,424 (18.6%) tested positive. Completion rates increased by age <50–59 years (N = 12,818; 48.2%), 60–69 years (14,982; 56.3%), and ≥70 years (N = 9,850; 55.6%) (P < 0.0001). The completion rate for males (52.7%; 15,297/29,025) did not differ significantly from females (53.3%; 22,353/41,901) (P = 0.09). By race, the completion rates of White patients (54.1%; 34,874/64,512) and Asian patients (56.9%; 493/867) were higher than those of Black patients (38.8%; 1,699/4,376) (P < 0.0001). Test completion declined with repeat mt-sDNA orders, with ≤32% completion rate after ≥3 orders. In a multivariable model, older age was associated with greater likelihood of a positive test (odds ratio 1.22, 95% confidence interval 1.20–1.24, P < 0.0001), and Black patients had lower odds of a positive test (odds ratio 0.65, 95% confidence interval 0.56–0.76, P < 0.0001).

DISCUSSION:
Only 54.7% of patients completed their mt-sDNA test order. Older individuals were more likely to complete testing and test positive. Black patients were less likely to complete testing and, unexpectedly, less likely to test positive. Further exploration of mt-sDNA utilization including better understanding of the determinants of uptake, appropriateness, and evaluation of outcomes at colonoscopy is needed.
Longitudinal Associations Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Subclinical Cardiovascular Measures in Chinese Children
Authors: Qiao Yanan , Yang Lili , Yang Hui , Zheng Miaobing , Zhao Min , Xi Bo 
Published: December 2024

INTRODUCTION:
The clinical utility of metabolic dysfunction-associated steatotic liver disease (MASLD) in predicting subsequent subclinical cardiovascular damages in pediatric population remains poorly understood.

METHODS:
Data on 1,161 Chinese children aged 10–15 years were used to assess the longitudinal associations of MASLD with subsequent subclinical cardiovascular measures.

RESULTS:
Compared with relatively healthy children, children with MASLD had abnormal vascular and cardiac structures, along with reduced cardiac diastolic function at the 2-year follow-up. In addition, children with MASLD had a significantly increased risk of high carotid intima-media thickness and left ventricular hypertrophy.

DISCUSSION:
These findings support the clinical utility of MASLD in predicting the development of subclinical cardiovascular damages in childhood.
Ciencia y desafíos en el noroeste argentino: un análisis de trayectorias personales y académicas de doctores
Authors: Canavire Vanina Belén , Del Valle Gutierrez Brenda Doris 
Published: December 2024

Este trabajo aborda las trayectorias personales y académicas de investigadores en la provincia de Jujuy, a partir de entrevistas biográficas. Desde un enfoque cualitativo con estudio de caso, se busca comprender las dinámicas familiares, de formación, docencia y labor científica de doctores en un contexto regional específico. La información obtenida se examina a la luz de los Estudios Sociales de Ciencia y Tecnología, así como de educación superior universitaria. Se realizó un análisis de progreso (descubrimiento, codificación y relativización) que reveló un panorama complejo donde convergen factores personales, institucionales y estructurales que moldean el desarrollo de la carrera científica. Como conclusión se ofrecen valiosas perspectivas sobre las modalidades de formación, producción y circulación del conocimiento en las últimas décadas en el noroeste argentino
Wpływ administracji publicznej na funkcjonowanie instytucji kultury – aspekty organizacyjne
Authors: Ablewicz Joanna 
Published: December 2024

This article discusses the organizational dependence of cultural institutions on their organizers, i.e. ministers, heads of central offices and local government units. The cultural organizer fulfils the role of administrator of a cultural institution, as its existence depends on him. First, he or she defines the purpose of the cultural institution, then issues an act on its establishment (in which its object of activity is defined, inter alia), adopts its statutes, equips the institution with property and resources to start and conduct its activity, appoints and dismisses its director, finances it, and finally may merge, divide, co-manage the cultural institution or liquidate it. The organizer is also obligated to provide the cultural institution with the resources necessary to start cultural activities and to maintain the facility in which those activities are carried out. The paper argues that the organizers of cultural institutions often treat them as their property, interfere in their activities, use their property free of charge and assign them tasks arbitrarily, without any legal empowerment. The statutes and other acts of selected cultural institutions analysed here, as well as the jurisprudence of administrative courts, allow us to conclude that cultural institutions still do not have organizational independence, and in fact their organizational dependence on the organizer is considerable, and consequently their duties, which they are obliged to fulfil without any basis for doing so, are also high.
Laparoscopic adrenalectomy in children with diverse adrenal pathologies: the impact of pre-operative imaging in decision making process
Authors: Kravarusic Dragan , Cohen Osher , Assi Zaki Elias , Markel Boaz , Konen Osnat , Rafael Orly , Dreznik Yael 
Published: December 2024

Abstract

Objectives
The aim of this study was to assess the impact of pre-operative imaging regarding selecting cases of children’s who underwent laparoscopic adrenalectomy due to adrenal masses in two tertiary medical centers.

Methods
We performed a retrospective review of all laparoscopic adrenalectomy performed at two tertiary medical centers in Israel between 2017 and 2023.

Results
Sixteen (n=16) patients, 10 girls and six boys, underwent laparoscopic adrenalectomy through a transperitoneal approach. The median age was 10 years (range: eight months to 17.3 years). Six masses were incidentalomas. Preoperative imaging (ultrasonography, CT, and MRI) demonstrated a mass in the right adrenal (n=9) and left adrenal (n=7), with tumor sizes ranging from 1.8 to 5.3 cm in maximum diameter. Operative results showed minimal blood loss and no conversions to laparotomy. There were no postoperative complications. Pathological diagnoses included neuroblastoma (n=8), cortical hormone-secreting tumors (n=3), pheochromocytoma (n=2), adrenal cortical adenoma (n=2), and adrenal metastatic Ewing sarcoma (n=1). Eleven masses were defined as benign and five as malignant tumors.

Conclusions
Laparoscopic adrenalectomy appears to be a safe and effective technique in selected cases with adrenal masses. Among our cohort, malignant masses were more common compared to the predominantly benign adrenal masses seen in adults. Vascular encasement was a major factor in determining the feasibility of the laparoscopic approach, with preoperative imaging playing a critical role in this assessment.
Radiochromic liquid dosimeter based on p-arsanilic acid for gamma radiation monitoring
Authors: El-Shawadfy El-Saeid R. , Farroh Hoda A. , Gafar Sameh M. 
Published: December 2024

Abstract
Organoarsenic can be applied to feed to improve feed efficiency or as a radiation dosimeter, as presented in this study. A developed radiochromic solution and powder based on p-arsanilic acid (P-ASA) was evaluated at various concentrations. Using a UV–vis Spectrophotometer, EPR analysis were operated, the spectrophotometric characteristics of P-ASA aqueous solutions that were both unirradiated and gamma-irradiated were evaluated. For applications involving moderate dose dosimetry, two absorption peak intensities were observed at λ
max 300 nm and 361 nm following gamma ray exposure within the range of up to 4.5 kGy. The results indicate that P-ASA solutions exhibit good dosimetric properties and can be considered as a dosimeter.
Predicting dynamics from structure in a sodium silicate glass
Authors: Christensen Rasmus , Smedskjaer Morten M. 
Published: December 2024

Abstract
Understanding the dynamics of atoms in glasses is crucial for unraveling the origin of relaxation and the glass transition as well as predicting transport properties. However, identifying the structural features controlling atom dynamics in glasses remains challenging. Recently, machine learning models based on graph neural networks (GNNs) have successfully been used to predict future dynamics, but these prior studies focused primarily on model systems such as Kob–Andersen-type Lennard–Jones mixtures. This study investigates the use of local descriptors, GNN models, and molecular dynamics simulations to clarify the atomics dynamics in a realistic glass system (sodium silicate) across varying time scales. By harnessing the capabilities of different structural representations, we develop effective models for predicting the dynamics of sodium ions within the glassy silicate network, based solely on the initial atom positions. We further demonstrate the viability of our approach through comparison to previously proposed methods. Our findings pave the way for designing new glass formulations with tailored dynamical properties (e.g., as glassy electrolytes for batteries).

Impact statement
Glass science has long grappled with understanding the fundamental nature and origin of glassy dynamics. The governing principles of atomic dynamics in glasses remain elusive as it is not obvious what to look for in the glass structure. While previous studies have focused on simplified model systems, we demonstrate for the first time that machine learning models can be used to accurately predict multi-time scale atomic dynamics in a complex oxide glass (sodium silicate) from the static atomic structure. By comparing different machine learning architectures, we establish that graph neural networks outperform conventional structural descriptors for dynamics prediction, with graph representations being able to effectively capture the complex multibody correlations that govern dynamics. Our findings show that the future dynamics in oxide glasses on time scales up to nanoseconds are at least partially encoded in the initial glassy configuration itself, showing that glassy dynamics is not a completely stochastic process. The capability to predict dynamics from structure has major implications as it could provide new tools for rational design of glassy materials with tailored dynamical properties and functionalities, possibly accelerating development of advanced glasses for applications in areas such as solid-state batteries and nuclear waste immobilization.

Graphical abstract
Determination of the effect of internet use and e-health literacy on birth worries in pregnant women
Authors: Altunkurek Seyma Zehra , Yilmaz Semra Tuncay , Tekin Özlem Moraloğlu 
Published: December 2024

Background: This study was carried out to determine the relationship between the internet use of pregnant women and e-health literacy and birth anxiety.
Methods: This descriptive study was conducted 313 pregnant Turkish woman in Ankara Turkey, from May 2018 to December 2018. The Introductory Information and internet usage e-health literacy scale (E-HLS) and the Oxford worries about labor scale (OWLS) used to measure participants’ birth anxiety and e-health literacy. To evaluate data that were not normally distributed, additional descriptive statistics, the Mann-Whitney U test, the Kruskal-Wallis analysis test and Pearson correlation analysis were employed.
Results: The (E-HLS) scale and the (OWLS) scale and median scores were 29.31±6.34 and 24.59±7.44, respectively. The majority of pregnant women had access to the internet, and had access to internet for the information given by the health care provider is not clear. Fetal development and nutrition delivery were the two most often mentioned topics of interest. We detected statistically significant relationships between Internet usage during pregnancy and income and education status (p<0.05). A moderately positive and statistically significant relationship was detected between e-health literacy and Oxford birth anxiety total score.
Conclusions: During antenatal visits and childbirth education classes, health professionals should help increase the e-health literacy of pregnant women, including the abilities to search, understand, and evaluate health information from electronic sources.
Mycobacterium abscessus presenting as a lung mass
Authors: Waghmare Siddharth Ravindranath , Kawade Snehal , Nair Jairaj P. 
Published: December 2024

is one of the leading causes of non-tuberculous mycobacterial infection. It presents commonly as lung nodules. We report a rare presentation of as a lung mass. A 38-year-old man with complaints of fever, chronic cough, and chest pain presented to our outpatient department. His chest X-ray and CT scan were suggestive of a left lower lobe mass lesion. The sputum cartridge-based nucleic acid amplification test was negative for tuberculosis. The patient was then subjected to bronchoscopy. was detected on bronchial washing. This patient was started on a multidrug regime. It consisted of an injection (intramuscular) of amikacin (thrice a week), oral linezolid, clarithromycin, and moxifloxacin. After 1 month of therapy, there was complete resolution of symptoms and X-ray opacity. The patient was continued on the aforementioned treatment. The clinical presentation of is non-specific. In this case report it presented as a mass lesion. This highlights the varied radiological presentation of the infection. Non-tuberculosis mycobacterium infection should be suspected if the initial workup of tuberculosis is negative.
A Review of the Predatory Adaptation and Applications of Eocanthecona furcellata (Hemiptera: Pentatomidae) as a Biological Control Agent1
Authors: Chen Gang , Liao Rentao , Ding Yishu , Ren Wei , Mao Zichao 
Published: December 2024

Abstract
Eocanthecona furcellata (Wolff) (Hemiptera: Pentatomidae: Asopinae) captures and feeds on a wide range of insect pests, making it an important biocontrol agent in agriculture and forestry with significant regional application and promotional potentials. This review summarizes current research information on E. furcellata focusing on taxonomy, morphological characteristics involved in predation, its natural prey, mass rearing, regional application and potential, integrated pest management (IPM) usages, ecological safety evaluations, as well as future prospects for its use in IPM programs.