bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik dan Motivasi Entrepreneur Terhadap Kinerja Bisnis
Authors: Megracia Sherly 
Published: September 2021

In the current era, it can be seen that business actors in Indonesia are dominated mainly by MSMEs. A high challenge for MSME entrepreneurs is that their capacity is required to plan, innovate, and be willing to take risks; it will make it easier for them to develop and grow successfully. This study aims to determine the effect of entrepreneurial characteristics and motivation on business performance. Respondents in this study were 130 samples, using the accidental sampling technique. The technique of collecting data uses a questionnaire that is distributed via a google form. Data analysis techniques using SEM with the help of software WarpPLS 7.0. This research shows that there is an effect of entrepreneurial characteristics and motivation on business performance both simultaneously and partially. The obstacles experienced by online shop entrepreneurs are the ability to innovate or creativity and the courage to take risks.

Abstrak
Di era sekarang seperti yang terlihat pelaku usaha di Indonesia sebagian besar didominasi oleh UMKM. Tantangan yang tinggi bagi wirausaha UMKM adalah mereka dituntut kapasitasnya untuk mampu membuat rencana kedepan, berinovasi juga kemauan mengambil risiko, akan memudahkan berkembang dan bertumbuh dengan sukses. Hal ini bertujuan untuk mengetahui pengaruh karakteristik dan motivasi entrepreneur terhadap kinerja bisnis. Responden dalam penelitian ini adalah sebanyak 130 sampel, dengan menggunakan teknik accidental sampling. Teknik pengumpulan data menggunakan kuesioner yang disebarkan melalui google form. Teknik analisis data menggunakan SEM dengan bantuan software WarpPLS 7.0. Hasil dari penelitian ini adalah terdapat pengaruh karakteristik dan motivasi entrepreneur berpengaruh terhadap kinerja bisnis baik secara simultan dan parsial. Kendala yang dialami oleh wirausahawan online shop adalah kemampuan melakukan inovasi atau dalam hal kreativitas, dan keberanian dalam menanggung risiko.
Kata kunci : Karakteristik, Motivasi Wirausaha, Kinerja Bisnis, Online Shop.
Tumor Cell-Derived Exosomal Circ-0072088 Suppresses Migration and Invasion of Hepatic Carcinoma Cells Through Regulating MMP-16
Authors: Lin Ye , Zheng Ze-Hao , Wang Jian-Xi , Zhao Zhen , Peng Tian-Yi 
Published: September 2021

Background: Tumor-derived exosomes (EXOs), commonly differentially expressed in circular RNAs, have been shown to be crucial determinants of tumor progression and may regulate the development and metastasis of hepatic carcinoma (HCC).Methods: Possibly differentially expressed circRNAs in patients with HCC were screened out from the Gene Expression Omnibus (GEO). EXOs were isolated from the culture medium of HCC cells and plasma of patients with HCC, followed by characterization by transmission electron microscope, NanHCCight, and western blotting. Additionally, RNA immunoprecipitation and luciferase reporter gene assays were carried out to explore the molecular mechanism of hsa_circRNA_103809 (circ-0072088) in HCC cells.Results: The screening results showed that circ-0072088 was highly expressed in patients with HCC, and its increase indicated unfavorable prognosis of patients according to quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Additionally, circ-0072088 was mainly secreted by HCC cells via EXOs in plasma of such patients, and its high level in plasma EXOs was closely associated with tumor node metastasis (TNM) staging and tumor size. Moreover, HCC-secreted EXOs mediated the degradation of miR-375 via circ-0072088 and upregulated MMP-16, thus suppressing the metastasis of HCC.Conclusion: Upregulated in patients with HCC, circ-0072088 may be an index for diagnosis and prognosis of HCC. In addition, HCC-derived EXOs coated with circ-0072088 might be a treatment for HCC, with the ability to inhibit the metastasis of HCC cells.
Epidemiology of Geographic Disparities of Myocardial Infarction Among Older Adults in the United States: Analysis of 2000–2017 Medicare Data
Authors: Yu Bin , Akushevich Igor , Yashkin Arseniy P. , Kravchenko Julia 
Published: September 2021

Background: There are substantial geographic disparities in the life expectancy (LE) across the U.S. with myocardial infarction (MI) contributing significantly to the differences between the states with highest (leading) and lowest (lagging) LE. This study aimed to systematically investigate the epidemiology of geographic disparities in MI among older adults.Methods: Data on MI outcomes among adults aged 65+ were derived from the Center for Disease Control and Prevention-sponsored Wide-Ranging Online Data for Epidemiologic Research database and a 5% sample of Medicare Beneficiaries for 2000–2017. Death certificate-based mortality from MI as underlying/multiple cause of death (CBM-UCD/CBM-MCD), incidence-based mortality (IBM), incidence, prevalence, prevalence at age 65, and 1-, 3-, and 5-year survival, and remaining LE at age 65 were estimated and compared between the leading and lagging states. Cox model was used to investigate the effect of residence in the lagging states on MI incidence and survival.Results: Between 2000 and 2017, MI mortality was higher in the lagging than in the leading states (per 100,000, CBM-UCD: 236.7–583.7 vs. 128.2–357.6, CBM-MCD: 322.7–707.7 vs. 182.4–437.7, IBM: 1330.5–1518.9 vs. 1003.3–1197.0). Compared to the leading states, lagging states had higher MI incidence (1.1–2.0% vs. 0.9–1.8%), prevalence (10.2–13.1% vs. 8.3–11.9%), pre-existing prevalence (2.5–5.1% vs. 1.4–3.6%), and lower survival (70.4 vs. 77.2% for 1-year, 63.2 vs. 67.2% for 3-year, and 52.1 vs. 58.7% for 5-year), and lower remaining LE at age 65 among MI patients (years, 8.8–10.9 vs. 9.9–12.8). Cox model results showed that the lagging states had greater risk of MI incidence [Adjusted hazards ratio, AHR (95% Confidence Interval, CI): 1.18 (1.16, 1.19)] and death after MI diagnosis [1.22 (1.21, 1.24)]. Study results also showed alarming declines in survival and remaining LE at age 65 among MI patients.Conclusion: There are substantial geographic disparities in MI outcomes, with lagging states having higher MI mortality, incidence, and prevalence, lower survival and remaining LE at age 65. Disparities in MI mortality in a great extent could be due to between-the-state differences in MI incidence, prevalence at age 65 and survival. Observed declines in survival and remaining LE require an urgent analysis of contributing factors that must be addressed.
Implementation of Interdisciplinary Province-Wide Webinar Series During the COVID-19 Pandemic by the Federation of Medical Specialists of Quebec (FMSQ): A Survey Study
Authors: Turkdogan Sena , Chen Tanya , McHugh Tobial , Tremblay Martin , Francoeur Diane , Daniel Sam J. 
Published: September 2021

Objectives: COVID-19 has forced a transformation in continuing professional development (CPD), shifting to virtual platforms. We report the results of a rapidly-implemented COVID-19 online interdisciplinary CPD webinar series. We aimed to determine if this virtual approach for large-scale CPD was relevant, appreciated, and effective for specialist physicians in Quebec.Methods and Analysis: This was a retrospective descriptive online survey-based study. The weekly virtual educational webinars took place between March 3, 2020 to June 15, 2020, resulting in a total of 26 webinars over 16 weeks. The study included all individuals who attended any of the webinar sessions, namely specialist physicians and department chiefs. Number of participants and overall appreciation of webinar sessions were data points collected.Results: Across all webinars, there were 8,500 unique specialist physicians which comprises 80.7% of the entire specialist practicing population in Quebec. Of note, every medical and surgical specialty was represented by attendance in at least one session. In total, 27,504 evaluation forms were completed out of all the sessions, meaning a 78.4% response rate. In post-webinar surveys, 97.6% of respondents agreed or strongly agreed that the webinars were pertinent to their practice and 94.6% agreed or strongly agreed that the presentation met their continuing professional needs.Conclusions: This novel interdisciplinary COVID-19 webinar series is a successful and appreciated strategy to maintain CPD amidst a global pandemic. One year later, it has become a mainstay in our toolbox and we trust this unique model of large-scale interdisciplinary CPD via webinar sessions is useful in normal times as well as in times of crisis.
Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review
Authors: Mortaheb Sepehr , Filippini Maria Maddalena , Kaux Jean-François , Annen Jitka , Lejeune Nicolas , Martens Géraldine , Calderón Maria Antonia Fuentes , Laureys Steven , Thibaut Aurore 
Published: September 2021

Background and Objectives: Persistent post-concussive symptoms (PCS) consist of neurologic and psychological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, may cause long-term disability, and reduce patients' quality of life. The aim of this review was to examine the possible use of different neuroimaging modalities in PCS.Methods: Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report the results.Results: A total of 80 out of 939 papers were included in the final review. Ten examined conventional MRI (30% positive finding), 24 examined diffusion weighted imaging (54.17% positive finding), 23 examined functional MRI (82.61% positive finding), nine examined electro(magneto)encephalography (77.78% positive finding), and 14 examined other techniques (71% positive finding).Conclusion: MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. The common functional patterns associated with symptoms of PCS were a decreased anti-correlation between the default mode network and the task positive network and reduced brain activity in specific areas (most often in the prefrontal cortex).Significance: Our findings highlight the importance to use functional approaches which demonstrated a functional alteration in brain connectivity and activity in most studies assessing PCS.
A Five-MicroRNA Signature Predicts the Prognosis in Nasopharyngeal Carcinoma
Authors: Wu Shixiong , Zhang Cen , Xie Jing , Li Shuang , Huang Shuo 
Published: September 2021

BackgroundThere is no effective prognostic signature that could predict the prognosis of nasopharyngeal carcinoma (NPC).MethodsWe constructed a prognostic signature based on five microRNAs using random forest and Least Absolute Shrinkage And Selection Operator (LASSO) algorithm on the GSE32960 cohort (N = 213). We verified its prognostic value using three independent external validation cohorts (GSE36682, N = 62; GSE70970, N = 246; and TCGA-HNSC, N = 523). Through principal component analysis, receiver operating characteristic curve analysis, and C-index calculation, we confirmed the predictive accuracy of this prognostic signature.ResultsWe calculated the risk score based on the LASSO algorithm and divided the patients into high- and low-risk groups according to the calculated optimal cutoff value. The patients in the high-risk group tended to have a worse prognosis outcome and chemotherapy response. The time-dependent receiver operating characteristic curve showed that the 1-year overall survival rate of the five-microRNA signature had an area under the curve of more than 0.83. A functional annotation analysis of the five-microRNA signature showed that the patients in the high-risk group were usually accompanied by activation of DNA repair and MYC-target pathways, while the patients in the low-risk group had higher immune-related pathway signals.ConclusionsWe constructed a five-microRNA prognostic signature, which could accurately predict the prognosis of nasopharyngeal carcinoma, and constructed a nomogram that could conveniently predict the overall survival of patients.
Identification of a Ferroptosis-Related Signature Model Including mRNAs and lncRNAs for Predicting Prognosis and Immune Activity in Hepatocellular Carcinoma
Authors: Chen Zi-An , Tian Hui , Yao Dong-Mei , Zhang Yuan , Feng Zhi-Jie , Yang Chuan-Jie 
Published: September 2021

BackgroundFerroptosis is a novel form of regulated cell death involved in tumor progression. The role of ferroptosis-related lncRNAs in hepatocellular carcinoma (HCC) remains unclear.MethodsRNA-seq and clinical data for HCC patients were downloaded from The Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal. Bioinformatics methods, including weighted gene coexpression network analysis (WGCNA), Cox regression, and least absolute shrinkage and selection operator (LASSO) analysis, were used to identify signature markers for diagnosis/prognosis. The tumor microenvironment, immune infiltration and functional enrichment were compared between the low-risk and high-risk groups. Subsequently, small molecule drugs targeting ferroptosis-related signature components were predicted via the L1000FWD and PubChem databases.ResultsThe prognostic model consisted of 2 ferroptosis-related mRNAs (SLC1A5 and SLC7A11) and 8 ferroptosis-related lncRNAs (AC245297.3, MYLK-AS1, NRAV, SREBF2-AS1, AL031985.3, ZFPM2-AS1, AC015908.3, MSC-AS1). The areas under the curves (AUCs) were 0.830 and 0.806 in the training and test groups, respectively. Decision curve analysis (DCA) revealed that the ferroptosis-related signature performed better than all pathological characteristics. Multivariate Cox regression analysis showed that the risk score was an independent prognostic factor. The survival probability of low- and high-risk patients could be clearly distinguished by the principal component analysis (PCA) plot. The risk score divided HCC patients into two distinct groups in terms of immune status, especially checkpoint gene expression, which was further supported by the Gene Ontology (GO) biological process, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Finally, several small molecule drugs (SIB-1893, geldanamycin and PD-184352, etc) targeting ferroptosis-related signature components were identified for future reference.ConclusionWe constructed a new ferroptosis-related mRNA/lncRNA signature for HCC patients. The model can be used for prognostic prediction and immune evaluation, providing a reference for immunotherapies and targeted therapies.
Heightened Stress Reactivity in Response to an Attachment Related Stressor in Patients With Medically Treated Primary Hypertension
Authors: Balint Elisabeth M. , Jarczok Marc N. , Langgartner Dominik , Reber Stefan O. , Endes Simon , Schmidt-Trucksäss Arno , Funk Alexandra , Klinghammer Julia , Campbell Susanne , Gündel Harald , Waller Christiane 
Published: September 2021

Background: A heightened stress reactivity to mental stress tasks has been shown in hypertensive patients and might contribute to a higher disease risk. We investigated this hyperreactivity with regard to an attachment related stressor that focuses on emotions instead of performance and we examined whether this effect can also be found in patients on antihypertensive drugs.Materials and Methods: Fifty patients with primary hypertension, treated with at least one antihypertensive drug, were compared with 25 healthy individuals. After 10 min of rest, they participated in an attachment-related interview (Adult Attachment Projective picture system, AAP) and were exposed to an attachment-related stressor (Separation Recall, SR), a short-time stressor which activates attachment-related emotions and thoughts by talking 5 min about a personal experience of loneliness. Blood samples to measure adrenocorticotrope hormone (ACTH), cortisol, norepinephrine, epinephrine, and dopamine were taken. Blood pressure, heart rate and arterial stiffness were measured at rest, after AAP, after SR and 10 min after recovery. Standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences (RMSSD) were calculated. Parameters were compared using Mann Whitney U-test and linear mixed-effects regression models controlling for age and body mass index (BMI) after logarithmic transformation if appropriate.Results: Healthy test persons were younger and had lower BMI than patients. Comparing the two groups there were no significant differences in blood pressure and heart rate at rest. Both stressors provoked a significant response in almost all parameters. Results of the post-estimation of contrasts from linear mixed-effects regression models showed a steeper rise in systolic BP and arterial stiffness as well as a more pronounced decline in SDNN in hypertensive patients than in healthy controls. Levels of cortisol rose earlier and higher in hypertensive patients than in healthy controls.Conclusion: Vascular, autonomic, and hypothalamic pituitary adrenal axis response is heightened in medicated subjects with hypertension in response to attachment-focused stressors compared to healthy subjects. We conclude that the remaining hyper-reactivity even with sufficient antihypertensive medication still poses a substantial risk for affected patients. New ways to diminish this risk should be developed.
SYSTEMATICAL COMPARATIVE FOR TWO SPECIES AMARANTHUS albus L. AND AMARANTHUS gracilis DEFS. (AMARANTHACEAE) IN IRAQ
Authors: Aliwy S. A. 
Published: September 2021

This study dealt with comparative taxonomic study for the two species Amarantus albus L. and Amaranthus gracilis Defs. in Iraq . It was included the important morphological characters for roots, stems, leaves ,petioles ,inflorescences and its parts ,floral parts ,fruits and seeds . Also the dimensions and properties of each part have been recorded ,even its colors which helps in isolated and diagnosed the two species, the first one recognized by its white stems while the other one had red stems, also the first species characterized by axillaries sessile inflorescences with so small florets while the other one had terminal clusters spike inflorescence . Stamens were three in first species with short filament while they were 2-3 stamens with long filament in the other one. Also the study determined the rat of the flowering period for the two species as well as the study of ecological and geographical distribution for the two species in Iraq, the results documented with pictures. It could be depended to studied traits of the plant species for classification.
DIGONESTIC ENVIRONMENTAL MONITERING SYSTEM IN A POULTRY HOUSE
Authors: & et al Al-Chalabi 
Published: September 2021

This experiment was conducted at a closed poultry house , Poultry Research Station , office of Agricultural Research, Ministry of Agriculture, Baghdad, Iraq, for the period from 2/9 to 14/03/2016 for total rearing of 35 days. To diagnose and monitoring the Environmental factors such as temperature, humidity , density, and the carbon dioxide levels inside the house during winter season, and its impact on the productive performance of broiler chickens Rose 308 breed .The dimensions of the house was ,length 35 m x width 7.5 m x Height 2.5 m, by total space volume 3656.25 m3. The ventilation system in the house was (negative pressure type). The house is totally closed, small fans for (minimum ventilation) in the winter are functioned, and large fans for ventilation in the evaporative cooling operation were used in the summer. 1000 sexed birds were used in this experiment imported through commercial hatchery in Abu Ghraib. The house was divided into three thermal Zones in order to find out whether heterogeneity in environmental conditions is existed in the house and at bird level .as a result the impact on the homogeneity in the weights of marketed birds . The treatments have been distributed into 32 rearing cages by the following order: 8 cages with the density of 50 birds / cage, the remaining 24 cages were divided into the density of 25 birds / cage. The results showed that there were significant differences between the treatments in the rate of body weight ,body weight gain, feed intake and feed conversion efficiency among densities and the three thermal zones due to the presence of cool air leaks into the house at the front ,End of the house, and its sides especially when fans are on , along with dead Air pockets that were identified in many places in the middle of the housed, yet this Zone was the one that had the best productive traits in comparison with the other two zones. The purpose of this experiment is to study environmental parameters homogeneity inside the shed in addition to impact of CO2 levels and impact of birds density on productive traits.
APPLICATION OF MULTIVARIATE ANALYSIS TO IDENTIFY DROUGHT TOLERANCE GENOTYPES OF MAIZE
Authors: & Kadhem Ahmed 
Published: September 2021

In order to identify maize (Zea mays L.) genotypes had tolerate drought, Seven drought indices and 18 maize genotypes were used, to determine the efficiency of theses indices to identify tolerant and susceptible genotypes, Also interpretation the relationship between these indices using principle component , cluster of multivariate analysis and rank-sum method. The results indicated that MP, GMP, and STI were positively and significant correlated with Yp and Ys. Therefore, these indices have the potential to identify genotypes own well performance to stress and non-stress conditions. Screening drought tolerant genotypes using these indices discriminating G8 (Zm32*Zm60) G2 (Zm69*Zm49), G (Zm60*Zm61), and G11 (Zm49*Zm60) in spring season; and G8 (Zm32*Zm60) G2(Zm69*Zm49 ), G15 (Zm49*Zm19) and G18 (Zm60*Zm51) for autumn season as tolerant genotypes and have a higher potential productivity under stress and non-stress conditions.
EFFECT OF CORN GLUTEN SUPPLEMENT TO LOW QUALITY ROUGHAGES TREATED WITH UREA ON CHEMICAL COMPOSITION AND IV VITRO DIGESTIBILITY
Authors: & Mohammed Hassan 
Published: September 2021

This study was conducted to determine the effect of corn gluten (0 and 9%) supplementation to low quality roughages (date palm frond, reeds, corn cobs and barley straw) treated with 5% urea on chemical composition and in vitro digestibility,The treatments were incubated for 0,20 and 30 days at ambient temperature (30-37 C°).The results showed that nitrogen content, cellulose, metabolizable energy(ME) dry matter InVitro digestibility (IDMD) and Organic matter InVitro digestibility (IOMD)were increased significantly (P<0.01).The dry matter (DM),organic matter(OM) ,neutral detergent fiber (NDF),hemicelluloses, Lignin and pH were significant decrease (P<0.01) in date palm frond by treated with urea and corn gluten.Nitrogen content, total digestible nutrients (TDN), ME, IDMD and IOMD had more(P<0.05) for corn cops treated with urea and corn gluten than un treated. The DM, OM,NDF, acid detergent fiber (ADF), cellulose and pH in corn cobs by treated with urea and corn gluten were Significant decreased (P<0.01). On the other hand, treated reeds resulted in increasing (P<0.01) in nitrogen content, hemecellulose, IDMD, IOMD, TDN and ME, and decreasing (P<0.01) in NDF, cellulose and ADF content. The result indicated that total nitrogen, IDMD, IOMD, ME and TDN improved significantly(P<0.01) by treated barley straw while OM content was decreased(P<0.01(.Furthermore the best incubation time which gave better improve nutrient value was associated with 20 and 30 days incubation time. We conclude from this study that it is possible to improve the nutritive value of low quality roughages by treated with urea and supplemented with corn gluten.