bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amelioration Effect of Soil Amendment on Growth and Yield of Vigna unguiculata L. Grown in Acidic and Alkaline Soils
Authors: Mofunanya A. A. J. , Effa E. A. , Udosen I. R. 
Published: July 2021

Aim: Amelioration effect of soil amendment on growth and yield of Vigna unguiculata L. grown in acidic and alkaline soils.
Study Design: The study was conducted in a randomized complete block design with five replicates.
Place and Duration of Study: Department of Botany, University of Calabar, Nigeria, between May and September, 2017.
Methodology: Composite soils from two locations Akamkpa (pH 4.0) and Odukpani (pH 9.0) were collected, mixed thoroughly with organic manure (OM) and agricultural lime (AL) singly and in combination, allowed to stay three weeks for proper blending before V. unguiculata seeds were sown. On seedlings germination, amelioration effect of soil amendment on growth and yield of cowpea grown in acidic and alkaline soils was studied at different periods of growth.
Results: Results revealed significant (P=0.05) increase in leaf area, plant height, number of leaves, leaf fresh and leaf dry weight, relative growth rate, net assimilation rate and leaf area ratio of V. unguiculata grown in acidic and alkaline soils treated with OM and AL. Pod length, number of pods plant-1, number of seeds pod-1, number of seeds plant-1, weight of 100 seeds increased significantly. Organic manure used singly and in combination was more effective in ameliorating soil pH effect than AL. Vigna unguiculata performed better in treated and untreated alkaline than in acidic soils. Least plant height for V. unguiculata grown in untreated alkaline soil at 12 weeks after sowing WAS was 60.22±0.16a cm and highest 119.63E2±.35g cm for plants grown in soil treated with AL1+OM1. Least number of seeds plant-1 for plants grown in untreated acidic soil at 12 WAS was 90.60±0.02a and the highest 139.18E2±0.02e for plants grown in soil treated with AL1+OM1.
Conclusion: An improvement in growth and seed yield of V. unguiculata grown in acidic and alkaline soils is feasible through the use of organic manure and agricultural lime.
Chemical Composition and Antioxidant Activity of Essential Oil of Coriandrum sativum L. Seeds Cultivated in Afghanistan
Authors: Jafari Samira , Mori Yoshihito 
Published: July 2021

Coriandrum sativum L. is an aromatic plant belonging to the Apiaceae (Umbelliferae) family, originating in the Mediterranean region. C. sativum is widely cultivated worldwide and has nutritional and medicinal values. The C. sativum seeds contain an essential oil that is used in different industries like pharmaceuticals, cosmetics, and food. This study aims to extract, analyze, and evaluate the antioxidant activity of C. sativum seed essential oil cultivated in Afghanistan. The essential oil was extracted by hydro-distillation (HD) extraction and analyzed by High-performance thin-layer chromatography (HPTLC). The HD extraction provided an essential oil yield of 0.16 % (v/w). Also, HPTLC analysis of the essential oil determined two components of the oil, linalool and myrcene. The quantification of linalool content and HPTLC method validation were determined using densitometric analysis. As a result, the linalool content was identified 60.06 %, and the HPTLC method proved as a valid method for analysis of the essential oil. Furthermore, the antioxidant activity of the essential oil was determined using DPPH radical scavenging assay and reported as IC50. The ascorbic acid utilized as the positive control, and the antioxidant activity of the essential oil evaluated in comparison with ascorbic acid. The IC50 of ascorbic acid and the essential oil were determined 0.02 ± 0.0004 (mg/ml) and 21.05± 0.284 (mg/ml), respectively. Thus, the essential oil showed lower antioxidant activity than ascorbic acid. This study is the first report on the extraction, chemical composition, and antioxidant activity of C. sativum seed essential oil cultivated in Afghanistan.
Diploma Nursing Final Year Students with that of Degree Nursing Final Year Students
Authors: Fating Lina S. , Sebastian Tessy 
Published: July 2021

Background: Everyone is special, but we also have a couple of things in common. In psychology, one of the most interesting questions is to get to grips with human nature and what makes a personality. The type of personality that we hold is essential to our human perception. This study aimed to compare the emotional maturity of diploma nursing final year students with that of degree nursing final year students.
Objective: 1. To evaluate the level of emotional maturity of final year students in diploma nursing. 2. To evaluate emotional maturity rates of degree nursing final year students. 3. To compare the level of emotional maturity of diploma nursing final year students with that of degree nursing final year students. 3. To associate the level of emotional maturity of diploma Students in the nursing final year with their demographic variables selected. 4. To associate the level of emotional maturity of degree nursing final year students with their selected demographic variables.
Materials and Methods: A Comparative study was conducted among diploma Nursing students from the final year and nursing students from the final year Wardha. Purposive sampling technique was used.
Result: The data obtained to describe the that 11 % of the diploma final year nursing students had extremely emotionally maturity level, 21 % of them had emotionally immature 56% moderately emotionally maturity level 12% of diploma final year nursing students had extremely emotionally immature level. Minimum emotional maturity score was 67 and maximum emotional maturity score was 207.Mean emotional maturity score was 97.28 ± 22.08. degree final year nursing students that 82% of the degree final year nursing students had extremely emotionally mature level, 05 of them had moderately emotionally mature level, 10% of them had emotionally immature level and 3% them had extremely emotionally immature. Minimum emotional maturity score was 73 and maximum emotional maturity score was 235.Mean emotional maturity score was 179.98 ± 41.25.
Conclusion: The majority of diploma final year nursing students statistically significant difference was found in emotionally mature are degree final year students. Hence H1 is accepted. There is positive correlation between emotional maturities of diploma Nursing students and in final year and nursing students in the final year.
Effectiveness of Mental Health First Aid Kit for Depression and Psychological Well-being in Adolescents
Authors: Mukherjee S. , Sebastian T. , Gawai J. 
Published: July 2021

Background: Psychological state for youth not just impacts physical wellness at the moment, but also in potential lives. One of the major setbacks with adolescents developing depression in India is that most of them are unaware of the situation and majorly receive therapeutic help after the situation turns chronic in nature. Mental Health First Aid explains how symptoms of mental disease should be recognized and managed.
Objectives: To develop, evaluate and validate the Mental Health First Aid Kit for depression among adolescents and their psychological well-being.
Materials and Methods: For this community approach study, the teachers from the selected schools at Wardha city will be trained as potential volunteers to conduct this experimental trial with the scholar. The efficacy of Mental Health First Aid Kitwill be assessed by using various scale. The pre and post values obtained will be subjected to statistical analysis.
Expected Results: The development of the proposed indigenous Mental Health First Aid Kit would facilitate positive outcomes in primary assistance to adolescents with mental health concerns.
Conclusion: The results of the proposed study will be helpful to encourage the adolescent individual to identify and seek primary care until a more definitive medical diagnosis and treatment is availed.
Service Quality in Rural Healthcare: An Exploration of Expectation Versus Veracity
Authors: Sangode Pallawi B. 
Published: July 2021

Purpose: This paper aims to scrutinize the healthcare service quality in the rural population of a developing economy like India. It further aims at analyzing the service quality gap of the healthcare sector as perceived by its customers.
Design/ Methodology/Approach: This paper used the SERVQUAL model to examine the service quality of the health care units. For this study, only public health care units from the rural areas were considered.
Findings: The results entail that the hospitals have little or no provision of necessary infrastructural facilities inside the hospital in terms of medical equipment. The healthcare personnel do not provide personalized attention to the patients. Research
Limitations: The study was limited to rural state-owned hospitals' status; the results and interpretations may not be completely applicable or relevant to the private sector hospitals and urban hospitals.
Practical Implication: The study clearly states that the patients know their expectations in terms of service quality.
Originality/ Value: Vivid research has been done to examine the quality of services provided by the healthcare units, the least of them focusing on the rural front. This study is a genuine work by the authors to understand the healthcare providers' rural population's expectations.
Roles and Rules of Some Regulatory Agencies around the World during COVID-19 Pandemic
Authors: Sawad Aseel Bin , Turkistani Fatema 
Published: July 2021

Objective: Collecting and synthesizing relevant data on COVID-19 from official sources of some different regulatory agencies around the world.
Methods: The information and actions related to responding to the COVID-19 situation were collected from the websites of some regulatory agencies, including the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), Health Canada (HC), Swiss Agency for Therapeutic Products (Swissmedic), and the Australian Therapeutic Goods Administration (TGA).
Results: All the regulatory agencies help in expediting the development of COVID-19 treatments and medical devices. These agencies also developed an international regulatory collaboration to develop cure models for the pandemic. While some of the agencies conduct the COVID-19 testing, like the US FDA, the others do not. The agencies also differ in their approaches towards resolving the pandemic. FDA and EMA are more aggressive in a way that they prioritize more testing and hospitalization coverage. However, as of the 22nd of June 2021, the FDA authorized the highest number (388) of diagnostic COVID-19 test kits followed by TGA (128), and EMA (88).
Conclusions: Although the regulatory agencies differ in their approaches towards resolving pandemic COVID-19, all regulatory agencies help in expediting the development of COVID-19 treatments and medical devices.
Qualitative Portrayal of Esomeprazole Magnesium by Exploring Diverse Analytical and Investigative Approaches
Authors: Kanwar Kapil , Gautam Surya Prakash 
Published: July 2021

Purpose: The present study was intended to qualitatively analyze and drive meaningful statistics for Esomeprazole magnesium; to establish its inherent properties qualitatively & quantitatively.
Methods: Esomeprazole magnesium was analyzed using various traditional & modern analytical and investigative tools viz FTIR, HPLC, UV spectroscopy, X-ray diffraction, zetasizer.
Results: The absorption maxima were found at 301 nm with UV Spectrophotometric and HPLC analysis. The particle size of the drug was analyzed through Malvern zetasizer employing water as diluent and found to be 11.818 µm. The quantitative solubility of Esomeprazole magnesium was predicted in various solvents at 25 0C and found that it was most soluble in methanol and was least soluble in distilled water. Solubility was also found to be pH-dependent. Solubility increases with an increase in pH. The order of solubility determined was; Methanol (1.214 mg/ml) > Phosphate buffer pH- 7.4 (0.521 mg/ml) > Simulated Intestinal fluid pH-6.8 (0.475 mg/ml) > Phosphate buffer pH- 6.8 (0.466 mg/ml) > Simulated Gastric fluid pH-1.2 (0.147 mg/ml) > 0.1 N HCl (0.131 mg/ml) > Distilled water (0.017 mg/ml). The predicted log P value was found to be 2.39.
Conclusion: Esomeprazole magnesium was qualitatively analyzed using various analytical techniques to establish its inherent properties quantitatively. It is an off-white amorphous powder with a characteristic obnoxious odor and slightly bitter taste. The drug was identified through FTIR, using the classification of characteristic peaks of functional groups in the spectrum and also additionally through analytical methods viz HPLC, UV spectroscopy and found the absorption maxima at 301 nm. The linear regression analyses of a standard plot from UV spectrophotometric analysis demonstrate an unswerving relationship in the concentration range of 5-30μg/ml. The log P value indicates that the drug is significantly lipophilic. Various Micromeritic parameters like the Angle of repose, compressibility index, and Hausner's ratio predict the inherent flow properties of Esomeprazole magnesium as Fair (aid not needed). The present study will be an asset in the development of a modified released quick action formulation (Tablet-in-Tablet), to offer quick and protracted relief in gastritis and allied disorders.
Identification of Fungal Bioactive Compounds Targeting MMP-9 for Endometriosis- An In silico Approach
Authors: Nabiya Farnaz , Devi C. Anchana , Rajamiriyam M. 
Published: July 2021

Background: Endometriosis is a chronic inflammatory disease of the female reproductive system characterized by the presence of endometrial tissue outside the uterus that affects 5 to 10% of women of reproductive age, which is approximately 176 million women in the world. The women suffering from endometriosis have been reported to have high levels of matrix metalloproteinase (especially MMP-9) which regulates the inflammatory process. Thus, the aim of this study is to investigate the naturally available anti-inflammatory fungal compounds that can target the MMP-9 by various in silico approaches.
Methodology: A wide variety of anti-inflammatory bioactive compounds were screened and five compounds were further selected based on ‘Lipinski’s rule of five’ using the PubChem database. The bioavailability, pharmacokinetics, ADMET properties and biological activity of these compounds were predicted computationally using databases such as SWISS-ADME, PubChem, pkCSM and PASS. The target 1L6J (Crystal structure of human matrix metalloproteinase MMP-9) structure was retrieved from the PDB database. Comparative analysis of the bioactive compounds with the target was performed by AutoDock 4.2.6 and further visualisation of the target residues interacting with the compounds was performed using LigPlot v.2. 2. tool.
Results: Based on the docking results, the compounds namely, Ergosterol peroxide, Lovastatin, Javanicin, Asperlin and Ergothioneine exhibited binding energy value of -10.25 kcal/mol, -8.4 kcal/mol, -7.64 kcal/mol, -7.07 kcal/mol and -6.19 kcal/mol respectively whereas Elagolix (control drug) exhibited binding energy value of -4.88 kcal/mol, thus, indicating that the selected bioactive compounds were seen to have better binding energy comparative to the control drug.
Conclusion: Ergosterol peroxide derived from edible mushroom might act as a potential lead compound for designing a therapeutic drug for treating endometriosis and this compound can further be explored to evaluate its level of toxicity and efficacy in the wet laboratory studies by in vitro and in vivo methods.
Quantitative Assessment of Age and Gender Related Changes in Human Lacrimal Fluid Composition in Subjects
Authors: Peggy Ohwin Ejiro , Ogheneyoma Ofulue Ofioritse , Chukwuebuka Nwogueze Bartholomew , Ejime Agbonifo-Chiiokwu , Oghenerukevwe Omeru , Kingsley Nwangwa Eze 
Published: July 2021

Purpose: The frequency of eyelids blink rate has effect on the integrity of the tear fluid and replacement of old of tears on the ocular surface. Comprehension of the effect of advancing age and gender on tears fluid stability and quality is contentious. Basal tears continuously bathe the ocular facet lubricating and providing protection from viral and bacterial infections, cooling the surface as warmth encourages pathogen. Basal tear dysfunction basically results in conjunctival and corneal conditions which exposes the ocular facet to dryness, ulceration, opacity and even blindness. This study determined the quantitative assessment of age and gender related changes in human lacrimal fluid composition in subjects
Methods: The design involved 400 (192 males and 208 females) human subjects aged 6 years and above who do not wear contact lenses, not on topical medication and having healthy eyes grouped into twelve groups based on age and gender. Maximum blink interval (for tear break-up time) and phenol red thread procedure (for tear volume) were carried out monocularly for each subject.
Results: Findings from this study have established that tear fluid stability among different age groups; are often higher for group 6-12years and lower for 60years and above; therefore, study established that tear fluid stability is age dependent. In addition, tear fluid stability (average MBI. Tear volume and flow rate) are gender independent.
Conclusion: The present study revealed that tears fluid breakup time increases with decrease in tears fluid flow rate, volume and flow.
Does community-based care have an effect on public attitudes toward the mentally ill?
Authors: Rössler W , Salize HJ , Voges B 
Published: July 2002

SummaryIn this cross-sectional study we have investigated the attitudes and feelings toward the mentally ill among the residents of two Central European regions which are at considerably different stages of development in moving toward community-based care, to see if we could connect differing patterns of attitudes in the two regions to the varying levels of development of psychiatric care. By using the telephone survey method, representative samples of interviewees were presented with two complexes of questions, measuring the social distance of the interviewee to the mentally ill and his/her feelings toward the mentally ill. Social rejection and feelings of the people toward the mentally ill in both regions were similar in the direction they took, however not so much in the intensity. The population of the community care area showed a slightly stronger rejection. But factor analysis clearly suggests a more rational and sophisticated position toward the patients in this population. The people living in the custodially-oriented catchment area, on the other hand, showed a more vague pattern in their attitudes.
Long‐term treatment with nicardipine for severe pre‐eclampsia
Authors: Seki H , Takeda S , Kinoshita K 
Published: July 2002

AbstractObjective: To evaluate the safety of long‐term nicardipine treatment in severely pre‐eclamptic women and their fetuses/newborns. Methods: We divided 50 pregnant women into three groups according to the length of their treatment: short‐term treatment of severely pre‐eclamptic women (7 days or less, n=20); medium‐term treatment also of severely pre‐eclamptic women (8–28 days, n=20); and long‐term treatment of women with severe superimposed pre‐eclampsia (29 days or more, n=10). Results: Nicardipine significantly lowered both systolic (P<0.01) and diastolic blood pressures (P<0.025) in all three groups. The incidence of delivery before 28 weeks of gestation was very low in all three groups. There were no maternal or fetal/neonatal adverse effects. Conclusion: Our results suggest that long‐term treatment with nicardipine for severe pre‐eclampsia is as effective and safe as a short‐ and medium‐term treatment.
Estrogen replacement therapy in breast cancer survivors
Authors: Guidozzi F 
Published: July 2002

AbstractObjective: To determine whether estrogen replacement therapy (ERT) adversely affected outcome of breast cancer survivors. Method: A prospective descriptive study of all breast cancer survivors who requested ERT because of intractable menopausal symptoms. All patients presented voluntarily as gynecological outpatients and were all given oral continuous opposed ERT: 20 premarin and medroxyprogesterone and four tibolone. Results: Twenty‐four patients who had previously been treated for breast cancer 8–91 months prior to their initiating ERT have been observed for 24–44 months. There were 15 patients with stage 1, eight with stage 2 and one with stage 4 breast cancer. The mean age of the patients at commencement of ERT was 48 years (range 42–61). Two patients had a biopsy of a suspicious breast nodule: both of which were benign. There have not been any recurrences to date. Conclusion: Breast cancer survivors did not have their outcome adversely affected by ERT during an observation period of 24–44 months.
Supply networks and complex adaptive systems: control versus emergence
Authors: Choi Thomas Y , Dooley Kevin J , Rungtusanatham Manus 
Published: July 2002

AbstractIn much of the current literature on supply chain management, supply networks are recognized as a system. In this paper, we take this observation to the next level by arguing the need to recognize supply networks as acomplex adaptive system(CAS). We propose that many supply networks emerge rather than result from purposeful design by a singular entity. Most supply chain management literature emphasizes negative feedback for purposes of control; however, the emergent patterns in a supply network can much better be managed through positive feedback, which allows for autonomous action. Imposing too much control detracts from innovation and flexibility; conversely, allowing too much emergence can undermine managerial predictability and work routines. Therefore, when managing supply networks, managers must appropriately balance how much to control and how much to let emerge.
Associations Between Baseline and Longitudinal Semiautomated Quantitative Joint Space Width at the Hip and Incident Hip Osteoarthritis: Data From a Community‐Based Cohort
Authors: Nelson Amanda E. , Smith Jacquelyn A. , Alvarez Carolina , Arbeeva Liubov , Renner Jordan B. , Murphy Louise B. , Jordan Joanne M. , Golightly Yvonne M. , Duryea Jeffrey 
Published: July 2021

ObjectiveTo evaluate quantitative joint space width (JSW) at 10‐, 30‐, and 50‐degree locations in relation to incident radiographic and symptomatic hip osteoarthritis (HOA) in a community‐based cohort.MethodsData were from Johnston County OA Project participants with supine hip radiographs at each of 4 time points; all had Kellgren/Lawrence (K/L) grades and quantitative JSW. We assessed covariates (age, race, height, weight, body mass index [BMI]) associated with quantitative JSW and hip‐level associations between quantitative JSW and HOA over time using sex‐stratified and multivariable‐adjusted linear mixed models. A cluster analysis with logistic regression estimated associations between quantitative JSW trajectory groups and incident radiographic HOA and symptomatic HOA.ResultsAt baseline, 397 participants (784 hips, 41% men, 24% Black, mean age 57 years) had a mean BMI of 29 kg/m2. Over a mean of 18 years, 20% and 12% developed incident K/L grade–defined radiographic HOA or symptomatic HOA, respectively. Quantitative JSW was more sensitive to changes over time at 50 degrees. Values were stable among men but declined over time in women. Heavier women lost more quantitative JSW; changes in quantitative JSW were not significantly associated with race, education, or injury in women or men. In women only, loss of quantitative JSW over time was associated with 2–3 times higher odds of radiographic HOA and symptomatic HOA; among women and men, narrower baseline quantitative JSW was associated with these outcomes.ConclusionHip quantitative JSW demonstrates marked differences in respect to sex, with significant loss over time only in women. Loss of quantitative JSW over time in women and narrower baseline quantitative JSW in men and women were associated with incident radiographic HOA and symptomatic HOA.