bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective and anti-inflammatory effects of myricetin 3-glucoside in a rat model of cerebral ischemia
Authors: Ye Shengshou , Ma Jing , Wang Xinlan , Ye Chunhua 
Published: January 2021

Purpose: To investigate the effect of myricetin 3-glucoside (M3GLS) on middle cerebral artery occlusion (MCAO)-induced cerebral ischemia in a rat model, and the mechanism of action involved.Methods: A cerebral ischemia rat model was established using MCAO under 10 % chloral hydrate anesthesia. Neurological severity score was determined by analyzing reflex, motor and sensory functions, as well as balancing potential. Infarction volume was determined using triphenyl tetrazolium chloride dye, while counting of Nissl bodies was done after toluidine blue staining. The protein expression levels of Bax and Bcl-2 were assayed using western blotting, while cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA).Results: Treatment of cerebral ischemia rats with M3GLS effectively reduced infarct volume, when compared to vehicle-treated group (p < 0.05). Moreover, M3GLS treatment significantly increased the population of Nissl bodies and effectively improved neurologic scores (p < 0.05). In M3GLS-pretreated rats, cerebral ischemia-induced elevation of protein expressions of TNF-α, IL-6 and IL-1β were significantly suppressed. M3GL treatment significantly reversed cerebral ischemia-mediated downregulation of Bcl-2 protein level, but markedly reduced cerebral ischemia-induced upregulation of Bax protein level (p < 0.05).Conclusion: M3GLS exerts protective effect against cerebral ischemia-induced brain injury in rats via downregulation of inflammatory cytokines. It reduces infarction volume in the brain of cerebral ischemia rats, and regulates Bcl-2/Bax protein ratio. Thus, M3GLS has a potential for use in the clinical management of cerebral ischemia.
Keywords: Myricetin, Neuroprotection, Anti-inflammation, Cerebral ischemia, Cytokines, Infarction
A preliminary study of in vitro and in vivo synergistic effects of ciprofloxacin and D-tyrosine against Pseudomonas aeruginosa isolates
Authors: Li Huirong , Jiang Wei , He Xiaoshuang , Chen Mengting 
Published: January 2021

Purpose: To investigate the synergistic antimicrobial effects of ciprofloxacin and D-tyrosine against drug-resistant bacteria.Method: The antimicrobial effects of ciprofloxacin and D-tyrosine on clinical isolates of multidrugresistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) no. 3556 were determined in vitro based on time-kill curve, and in vivo in P. aeruginosa-zebrafish infection model. Furthermore, 30 clinical isolates of multidrug-resistant P. aeruginosa were used in vitro to ascertain the synergistic effect of the two agents.Results: Combined use of ciprofloxacin and D-tyrosine produced synergistic effects against the clinical isolate of P. aeruginosa no. 3556 in vitro and in vivo. Synergism occurred in 96.67 % (95 % CI, range 83.33 - 99.41 %) of the clinical isolates, and ciprofloxacin dose was reduced in 90 % (95 % CI, range 74.38 - 96.54 %) of the clinical isolates in vitro.Conclusion: These preliminary results suggest that the combination of ciprofloxacin and D-tyrosine is a promising therapeutic strategy against MDR P. aeruginosa infections.
Keywords: Ciprofloxacin, D-tyrosine, Synergistic, P. aeruginosa, Zebrafish infection model, Time-killing curve
Phytochemical analysis and hepatoprotective activity of Raphanus sativus var. sativus in Sprague-Dawley rats
Authors: Rahman Heshu Sulaiman , Bayz Kashan Alaalddin , Hussein Ridha Hassan , Abdalla Azad Ismael , Othman Hemn Hassan , Amin Kawa Mohammad , Abdullah Rasedee 
Published: January 2021

Purpose: To determine the phenolic and flavonoid contents of R. sativus rhizome ethanol extract and the hepatoprotective effect of the extract in rats.
Methods: Folin–Ciocalteau and aluminum chloride colorimetric tests were used to determine the contents of phenols and flavonoids in the R. sativus extract. Male Sprague-Dawley rats induced with CCl4 to develop hepatotoxicity were treated orally with R. sativus extract for 4 weeks. The antioxidant and anti-inflammatory effects of the extract on the liver were determined by evaluating the concentration of oxidative analytes, serum liver enzymes and lipids, and hepatic histopathology and cytochrome P450 2E1 expression.
Results: R. sativus extract significantly (p < 0.05) reduced the hepatotoxic effect of CCl4 via its antioxidant activities and protection of liver tissues from oxidative damage.
Conclusion: The hepatoprotective effects of R. sativus rhizome ethanol extract are attributed to its highphenolic and flavonoid contents.
Keywords: R. savitus rhizome, Phenols, Flavonoid contents, antioxidant, Hepatoprotective
Quality of life of patients with chronic kidney disease in two health facilities in Delta State, Nigeria
Authors: Aghoja Ogheneovo C. , Akonoghrere Rita O. , Odili Valentine U. , Ajagbe Omasan 
Published: January 2021

Purpose: To determine patients’ quality of life (QoL), impact of socio-demographic characteristics as well as biochemical parameters on the quality of life of chronic kidney disease patients.
Methods: The study was a prospective, cross-sectional study carried out in the Renal Units of Central Hospital, Warri and Delta State University Teaching Hospital, Oghara, both in Nigeria. The quality of life of the patients was assessed using the generic core of Kidney Disease Quality of Life Short Form (KDQOL-SFTM) questionnaire. Data obtained were coded into the KDQOL--SFTM scoring program (version 1.3), while descriptive and inferential analyses were done using SPSS
Results: Overall, the quality of life scores of patients with chronic kidney disease in both Physical and Mental Health components (PCS and MCS) was low. Respondents’ PCS scores in Central Hospital Warri was 31.08 ± 4.62 while that for respondents in DELSUTH was 31.75 ± 6.01, (p = 0.39). Similarly, the MCS score for respondents in Central Hospital Warri was 37.73 ± 3.37 while it was 37.68 ± 4.09 for DELSUTH (p = 0.94). These scores were lower than the standard norm, which is 50 There was no relationship between socio-demographic characteristics and the quality of life of the respondents in both health facilities. Serum creatinine and potassium showed a negative association with quality of life PCS (p = .025 and p = .006; 2-tailed), respectively.
Conclusion: In general, the QoL of patients with chronic kidney disease in the two surveyed settings was low. None of the socio-demographic characteristics had a significant relationship with the QoL of the respondents in both health centres. There was a negative association between PCS score and both creatinine and potassium.
Keywords: Quality of life (QoL), Patients, Chronic kidney disease, Creatinine, Potassium
AN ANALYSIS OF FINANCIAL PERFORMANCE AND INVESTOR’S EXPERIENCE OF INDIAN RENEWABLE ENERGY INDUSTRY
Authors: Devaraja T. S. , Jagadeesha D. K. 
Published: January 2021

The development of the renewable energy industry is an important support for the sustainable development of the social economy. It is strategic significance in economic and national security is immeasurable. The process of cultivating, developing, and upgrading the renewable energy industry in India is a comprehensive system that includes finance, resources, technology, and management. Renewable energy finance is a new area of public policy that requires innovation and research that will have a significant impact on investors in the World. Till today, many researchers think renewable energy is an issue of science and engineering, but the future of renewable energy is no longer about science and technology; it's all about access to finance. The renewable energy sector in India is growing rapidly and presents an opportunity for strong financial returns. The present research paper aims to know the financial performance of selected renewable energy companies of the Indian renewable energy industry through various financial ratios. The financial performance of any industry is effect to their respective industrial investors. Hence, investors' experience is analyzed. A specific group of investors who invest in the renewable energy industry is selected and posed a structured questionnaire to know their investment experience in the renewable energy sector in India.
JEL Classification Codes: F36, P17, G23, Q29, Q43, L7
Bibliometrics versus altmetrics: Researchers’ attitudes in Slovakia
Authors: Melicherová Michaela , Ondrišová Miriam , Šušol Jaroslav 
Published: January 2021

Objective. The paper presents principal theoretical starting points and an overview of attitudes to altmetrics-based research evaluation among scientists of various disciplines in Slovakia, more specifically in comparison with traditional, bibliometric approaches.
Design/Methodology/Approach. We used a questionnaire and asked researchers from various disciplines about their knowledge of principle characteristics defining the altmetrics and about their attitudes towards the application of bibliometrics and altmetrics approaches in the processes of research evaluation. The questionnaire covered a wide range of issues, predominantly associated with interpretation and perception of the importance of alternative indicators, including the factors influencing the interpretation. In this analysis, we concentrate on those parts of research reflecting the willingness of respondents to accept alternative indicators as part of research/science assessment.
Results/Discussion. The attitude to the application of alternative indicators in research assessment is not significantly more negative among Slovak scientists if we compare it to other countries. The citations are still a respected indicator perceived as a tool for creating bonds within science. If they are perceived as obsolete or insufficient, it relates to the experience of researchers whose results are predominantly aimed at non-academic target group or if they are active in the research of social phenomena and problems. Due to pragmatic reasons connected with research financing, however, registering the citations is a generally accepted priority. Familiarity and practical experience with social media were identified as one of the factors influencing the interpretation of alternative indicators in the environment of both public and academic media.
Conclusions. Traditional bibliometric methods, especially in the area of research evaluation, are still preferred over the altmetrics. The scientists realize that the kind of attention captured by the indicators based on social media is not comparable with the citation-based impact. Or, more precisely, that altmetrics reflects a different kind of impact whose correspondence with a traditional world of bibliographic citations remains to be explored.
Originality/Value. The article presents the results of original research carried out in the community of scientists in Slovakia, applying quantitative research methods. It contributes to the results of previous studies on the attitudes and acceptance of altmetrics in the research community, with a special focus on research assessment.
ACO powered by Local Searches Algorithms for the Solution of TSP Problems
Authors: Ahmed Nisreen L. 
Published: January 2021

Swarm intelligence is a relatively new approach to problem solving that takes inspiration from the social behaviors of insects and other animals. Ants, in particular, have inspired a number of methods and techniques among which the most studied and successful is the general-purpose optimization technique, also known as ant colony optimization, In computer science and operations research, the ant colony optimization algorithm (ACO) is a probabilistic technique for solving computational problems which can be reduced to finding good paths through graphs. Ant Colony Optimization (ACO) algorithm is used to arrive at the best solution for TSP. In this article, the researcher has introduced ways to use a great deluge algorithm with the ACO algorithm to increase the ability of the ACO in finding the best tour (optimal tour). Results are given for different TSP problems by using ACO with great deluge and other local search algorithms.
Burial architecture. 3D dissemination study for a selection of Byzantine graves
Authors: Mileto Camilla , Vegas López-Manzanares Fernando , Cristini Valentina , Cabezos Bernal Pedro M. 
Published: January 2021

<p class="VARAbstract">The former polis of Tall-as-Sin (in the current province of Deir ez-Zor, Syria) grew considerably during Justinian's reign in the 6<sup>th</sup> century AD. Its cemetery, outside the walls, presents an extraordinary Byzantine necropolis, where 163 hypogea graves were documented, thanks to recent archaeological campaigns financed by the Ministry of Culture (PAMES-Sirio Euphrates Middle Archaeological Project). This paper presents the research for obtaining three-dimensional (3D) models of graves, selected in the cemetery, by combining information (obtained from planimetric and photographic surveys of the site) with taxonomic features (types of arcosolia, vaults, accesses, stairways...). The 3D modelling process is carried out using data collected during the survey of the graves. These data are then used to restore the surfaces which cover the burial chambers dug out in the ground. The modelling technique was based on generating surfaces, incorporating the different sections and profiles obtained during the data collection phase. The surfaces generated enclose the volume of the dug-out space so that the definitive grave models were obtained using a simple Boolean operation, removing these volumes from a prism-shaped piece representing a portion of the land, thus emptying the interior. The result has provided a reliable and rigorous graphic basis for the design and printing of 3D mockups, contributing to the dissemination of the exhibition called "A retrospective on five years of archaeological activities in Syria".</p><p><strong>Highlights:</strong></p><ul><li><p>Contributing to Byzantine architecture classification in the Middle East, including specific case-studies, interesting both from archaeological and architectural research fields.</p></li><li><p>Experimenting and investigating tools for the study, representation and conservation of archaeological finds, combining 3D digital and 3D printing mockups.</p></li><li><p>Incorporating resources for promoting and disseminating archaeological and architectural heritage, raising awareness among local Syrian population and authorities, allowing them to rediscover their own heritage, often neglected.</p></li></ul>
A Rare Case of Bilateral Congenital Radial Head Dislocation: A Case Report
Authors: Ramprasath Dhurvas Ramlal , Esthak Antony Jaya Micheal 
Published: January 2021

ABSTRACT

Background
Congenital radial head dislocation by far is a rare condition and also the most common congenital anomaly of elbow. It causes symptoms such as joint stiffness, snapping, locking, or pain; however the diagnosis is sometimes made incidentally from X-rays. Surgical management includes osteotomy of radius, osteotomy of ulna, or radial head excision.

Aim and objective
The treatment goal is to ameliorate the symptoms and obtain a joint with a full range of motion.

Case description
Only unilateral cases have been described in literature until now. This article presents a case of bilateral congenital radial head dislocation in a pediatric girl with progressing valgus deformity, treated surgically by a newer technique. We successfully performed an ulnar osteotomy and distraction osteogenesis of ulna with an UMEX external fixator. Once the radial head was brought to the level of the joint, open reduction was done.

Conclusion
The clinical and functional outcomes were satisfactory.

Clinical significance
Even though various surgical options are available for the management of congenital radial head dislocation, radial head preserving surgery will benefit the patient on the long run by avoiding the development of distal radioulnar joint problems. Our procedure helps in achieving this goal.
How to cite this article
Ramprasath DR, Esthak AJM. A Rare Case of Bilateral Congenital Radial Head Dislocation: A Case Report. J Orth Joint Surg 2020;2(2):66–69.
Safe Clavicle Fracture Surgery
Authors: Subbiah Venkatesh Babu 
Published: January 2021

ABSTRACTThe surgical treatment is being advocated for all types of displaced clavicle fractures currently. At the same time, the neurovascular and other serious operative complications are in rise. This article updates the applied anatomical knowledge and operative skills required for the orthopedic surgeon who intends to surgically fix the clavicle fracture safely.How to cite this article:Babu SV. Safe Clavicle Fracture Surgery. J Orth Joint Surg 2020;2(2):62–65.
Analisis Kesalahan Siswa Menyelesaikan Soal Cerita Materi Barisan dan Deret Aritmetika Kelas XI MIA SMA Al-Ikhlas Lubuklinggau
Authors: Sari Murni Anita , Efuansyah E , Fitriyana Nur 
Published: January 2021

Abstract: This study aims to find out what types of errors and factors cause students to make mistakes in solving the arithmetic sequence and sequence material for class XI MIA SMA Al-Ikhlas Lubuklinggau. The research method used is descriptive qualitative. Data collection techniques in research using observation, interviews and documents. Data analysis procedure with the steps: data reduction, data presentation and conclusion. The results showed that there were errors made by students of class XI MIA SMA Al-Ikhlas Lubuklinggau in solving story questions about arithmetic sequences and series, namely: errors in understanding questions (49.99%), question transformation (50%), operation process (79.16 %) and writing the final answer (88.89%). The overall average error is (67.01%) with the high category. Based on the results of the interview the causes of students made mistakes, namely: students forgot and were unable to write information into mathematical symbols, did not know the formulas that should be used in the questions, were in a hurry because time was running out, were not careful, were mistaken in writing the operation signs, did not know which steps were must be done, forgetting to write down conclusions, and consider the final answer only to get the value that is sought.
Keywords: Analysis, Errors, Problem Stories, Sequences and Arithmetic Series.
Highly time-resolved measurements of element concentrations in PM10 and PM2.5: comparison of Delhi, Beijing, London, and Krakow
Authors: Rai Pragati , Slowik Jay G. , Furger Markus , El Haddad Imad , Visser Suzanne , Tong Yandong , Singh Atinderpal , Wehrle Günther , Kumar Varun , Tobler Anna K. , Bhattu Deepika , Wang Liwei , Ganguly Dilip , Rastogi Neeraj , Huang Ru-Jin , Necki Jaroslaw , Cao Junji , Tripathi Sachchida N. , Baltensperger Urs , Prévôt André S. H. 
Published: January 2021

Abstract. We present highly time-resolved (30 to 120 min)
measurements of size-fractionated (PM10 and PM2.5) elements in two
cities in Asia (Delhi and Beijing) and Europe (Krakow and London). For most
elements, the mean concentrations in PM10 and PM2.5 are higher in
the Asian cities (up to 24 and 28 times, respectively) than in Krakow and
often higher in Delhi than in Beijing. Among European cities, Krakow shows
higher elemental concentrations (up to 20 and 27 times, respectively) than
London. Hourly maximum concentrations of Pb and Zn reach up to 1 µg m−3 in Delhi, substantially higher than at the other sites. The
enrichment factor of an element together with the size distribution allows
for a rough classification of elements by major source. We define five
groups: (1) dust emissions, (2) non-exhaust traffic emissions, (3) solid fuel
combustion, (4) mixed traffic/industrial emissions, and (5)
industrial/coal/waste burning emissions, with the last group exhibiting the
most site-to-site variability. We demonstrate that the high time resolution
and size-segregated elemental dataset can be a powerful tool to assess
aerosol composition and sources in urban environments. Our results highlight
the need to consider the size distributions of toxic elements, diurnal
patterns of targeted emissions, and local vs. regional effects in
formulating effective environmental policies to protect public health.
El traje escénico en la Danza Española: importancia y simbolismo
Authors: Suárez Muñoz Rosa María , Ortiz Camacho María del Mar , Baena Extremera Antonio 
Published: January 2021

Resumen: El vestuario teatral, en la génesis de un proyecto escénico de danza, se considera un elemento más cuya importancia radica en su significación. El objetivo general de este trabajo ha sido constatar la importancia del traje escénico como herramienta transmisora de conceptos y como elemento simbólico que aporta un sentido a la interpretación de la Danza Española. Se ha estudiado el uso de este vestuario desde una perspectiva profesional (Ballet Nacional de España (BNE), intérpretes y coreógrafos de reconocido prestigio) y desde una perspectiva educativa (Conservatorios Profesionales de Danza de Andalucía-España (CPDA)). Se ha realizado una triangulación metodológica combinando investigación cuantitativa y cualitativa utilizando como instrumentos básicos el cuestionario y entrevistas previamente validadas. Como conclusión, resalta la importancia otorgada al uso del vestuario teatral en la Danza Española como herramienta comunicativa intencional, así como su aportación a la interpretación en la representación escénica, confirmándose así las hipótesis planteadas.Abstract: The theatrical costumes, in the genesis of a scenic dance project, are considered one more element whose importance lies in its significance. The aim of this paper has been to verify the importance of it as a communicating tool of concepts and as a symbolic element that contributes a sense to the interpretation of Spanish Dance.The use of this costume has been studied from a professional perspective (National Ballet of Spain (BNE), renowned performers and choreographers) and from an educational perspective (Professional Dance Conservatories of Andalusia (Spain) (CPDA)),making a methodological triangulation that combines quantitative and qualitative research, using the questionnaire and previously validated interviews as basic instruments. As a conclusion, the importance given to the use of theatrical costumes in Spanish Dance as an intentional communicative tool stands out, as well as their contribution to the interpretation in the scenic representation, confirming the hypotheses raised.