bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrepreneurial leadership: the key to develop creativity in organizations
Authors: Mehmood Muhammad Shahid , Jian Zhang , Akram Umair , Tariq Adeel 
Published: February 2021

PurposeEntrepreneurial leadership has been developed from the existing leadership and entrepreneurship literature as a new leadership theory to meet the dynamic changes in the 21st century. Accordingly, the main purpose of this study is to investigate the effect of entrepreneurial leadership on employee creativity and the mediating influence of psychological empowerment and psychological safety, with the lens of social learning theory.Design/methodology/approachData were collected from the manufacturing sector of Pakistan with a sample size of 280 dyads of managers and employees. A two-step analytical strategy was adopted through which the measurement model was validated by using confirmatory factor analysis and structural equation modeling to estimate the structural model to fit the data. The bootstrapping method was applied for testing the mediation analysis.FindingsThe current study found that entrepreneurial leadership positively related to employee creativity. Moreover, it was found that psychological empowerment and psychological safety mediated the relationships between entrepreneurial leadership and employee creativity.Research limitations/implicationsThe findings of the current study provide guidance to managers and businessmen on how to develop the creative skills of employees by adopting entrepreneurial leadership behaviors. Besides, this study enriches the literature by exploring the performance mechanism of entrepreneurial leadership to develop employee creativity.Originality/valueThe current study is considered the first to examine the role of entrepreneurial leaders in stimulating employee creativity through psychological safety and psychological empowerment. As such, it enriches the creativity literature by exploring the employee creativity mechanism through entrepreneurial leadership and validating the importance of psychological factors in the development of creativity compared to previous studies, which have focused primarily on the concept or scale development of entrepreneurial leadership. Furthermore, it provides several theoretical and managerial implications along with future opportunities.
Employee engagement constructs: “CARE” model of engagement – need to look beyond the obvious
Authors: Mani Swaminathan , Mishra Mridula 
Published: February 2021

PurposeThe purpose of this article is to identify new variables that form the core building blocks of employee engagement model which can be leveraged by human resources' (HR) practitioners to develop HR strategies to drive employee engagement initiatives in their companies.Design/methodology/approachThe authors have undertaken extensive literature review to identify the variables that enhances engagement. These variables are yet to be leveraged fully in engagement models that have been developed but have the potential to impact the motivation levels of the employees. Exploratory survey to validate the relevance of these variables was conducted and subsequently these variables were grouped into a Context, Altruistic, Resonance and Enable (“CARE”) framework that can be leveraged by HR practitioners.FindingsThe changing nature of workforce, increasing diversity and tenure of jobs has resulted in changing aspirations of employees as well. The building blocks hitherto adopted by companies to craft their employee engagement strategies have to undergo a perceptible change as well. This paper offers an alternative perspective of relooking the engagement levers currently adopted by firms (work environment, autonomy, appreciation, organization support, etc.) and proposes 15 new building blocks (resonant connections, value congruence, socialization practices, micro-moments of connections, fit amongst others) which are logically grouped under CARE model over which employee engagement strategies can be built by companies.Originality/valueThis paper provides insights into this important concept of employee engagement using a set of newer constructs that can form the foundation of newer models that will drive future HR strategies to enhance engagement.
Long‐term efficacy and safety of tildrakizumab in Japanese patients with moderate to severe plaque psoriasis: Results from a 5‐year extension of a phase 3 study (reSURFACE 1)
Authors: Imafuku Shinichi , Nakagawa Hidemi , Igarashi Atsuyuki , Morita Akimichi , Okubo Yukari , Sano Shigetoshi , Tada Yayoi , Nemoto Osamu , Rozzo Stephen J. , Kawamura Masaki , Ohtsuki Mamitaro 
Published: February 2021

AbstractThe three part, double‐blind, randomized, controlled reSURFACE 1 trial and extension study (NCT01722331) evaluated efficacy and safety of tildrakizumab in adults with moderate to severe plaque psoriasis. Patients with ≥50% improvement from baseline in Psoriasis Area and Severity Index (PASI 50) following treatment with tildrakizumab 100 mg (TIL100) or 200 mg (TIL200) could enter the optional long‐term extension study and continue treatment at the same dose for an additional 192 weeks. This subgroup analysis assessed the long‐term efficacy and safety of tildrakizumab treatment for Japanese patients enrolled in reSURFACE 1 for up to 5 years of treatment. The primary efficacy outcomes were the proportions of patients who maintained PASI 75 and Physician Global Assessment (PGA) clear or minimal with ≥2‐grade reduction from baseline (PGA 0/1) from base study week 64 to extension week 192. Secondary outcomes were the proportion of patients who maintained PASI 90/100 from base study week 64 to extension week 192. Adverse events (AEs) were monitored throughout the study and for up to 20 weeks after the last study visit. Of the 120 Japanese patients who entered the reSURFACE 1 extension study, 43 (79.6%) patients receiving tildrakizumab 100 mg and 58 (87.9%) patients receiving tildrakizumab 200 mg completed the extension study. Of all Japanese patients with PASI 75/90/100 and PGA 0/1 at week 64, 85%/88% receiving TIL100/TIL200 maintained PASI 75, 70%/96% maintained PASI 90, 63%/67% maintained PASI 100, and 68%/72% maintained PGA 0/1 at extension week 192. AEs led to discontinuation in 1.7 patients per 100 patient‐years (P100PY) receiving tildrakizumab 100 mg and 0.8 P100PY receiving tildrakizumab 200 mg. Incidences of severe infections, malignancies, confirmed major adverse cardiac events, and hypersensitivity reactions were low in both treatment groups. Through 5 years of treatment, tildrakizumab maintained efficacy and was well tolerated with low rates of AEs of special interest.
Research, kindness and the antifragility of emergency medicine
Authors: Fatovich Daniel M 
Published: February 2021

AbstractAntifragility is a property of things that benefit from shocks, randomness and uncertainty and love adventure and risk. This describes emergency medicine. Improving evidence‐based medicine requires a learning health system, where the whole system is constructed to advance patient care via research driven excellence. So we need to develop our own evidence base by embedding research into everyday practice. Clinical research is messy but the repeated stress testing of clinical practice via research enhances our antifragility. This is even more important because our world is complex, as are humans. Unfortunately, the human brain is hard wired for simplicity, making us disinclined to challenge the status quo. Yet probably <10% of our practice is supported by high‐level evidence. Research is altruistic and a form of kindness for our patients, which includes having a culture of research within a learning health system, so that we can be thoughtful!
Coquettish Mothers across the Atlantic: Gendered Liberty, Disciplinary Sexuality and Colonial Productivity in Lady Susan and The Coquette
Authors: Jung Seohyon 
Published: February 2021

AbstractThis article reads Jane Austen’s Lady Susan alongside Hannah Webster Foster’s The Coquette in the context of the shifting British colonial relationship with America. I present the coquettish mother as a historically significant literary figure who embodies the rival claims of Enlightenment liberty and the necessity to control national (re‐)production via an exploitative, colonial logic that enables ideological formations of domesticity. My analysis of the socially corrective drive captured in these novels suggests that British anxiety over the loss of the American colonies prompted an urgent and ongoing effort to redefine productivity by obscuring the economic consequences of female sexuality.
ADR databases for on‐site clinical use: Potentials of summary of products characteristics
Authors: Eiermann Birgit , Rodriguez Daniel , Cohen Paul , Gustafsson Lars L. 
Published: February 2021

AbstractAdverse drug reactions (ADRs) for all drugs in Europe are described in the legally approved Summary of Product Characteristics (SmPC). An overview of all ADRs of the patients’ drug list can support healthcare staff to link patient symptoms to possible ADRs. We review the possibilities and challenges to extract ADR information from SmPCs or American Structured Product Labels and present the development of our semi‐automated procedure for extraction of ADRs from the tabulated section in the SmPCs to create a database, named Bikt, which is regularly updated and used at point of care in Sweden. The existence of five major table formats for ADRs used in the SmPCs required the development of different parsing scripts. Manual checks for correctness for all content have to be performed. The quality of extraction was investigated for all SmPCs by measuring precision, recall and F1 scores and compared with other methods published. We conclude that it is possible to semi‐automatically extract ADR information from SmPCs. However, clear technical and content guidelines and standards for ADR tables and terms from drug registration authorities would lead to improved extraction and usability of ADR information at point of care.
Forecasting sensitive targets of the kynurenine pathway in pancreatic adenocarcinoma using mathematical modeling
Authors: Alahdal Murad , Sun Deshun , Duan Li , Ouyang Hongwei , Wang Manyi , Xiong Jianyi , Wang Daping 
Published: February 2021

AbstractIn this study, a new mathematical model was established and validated to forecast and define sensitive targets in the kynurenine pathway (Kynp) in pancreatic adenocarcinoma (PDAC). Using the Panc‐1 cell line, genetic profiles of Kynp molecules were tested. qPCR data were implemented in the algorithm programming (fmincon and lsqnonlin function) to estimate 35 parameters of Kynp variables by Matlab 2017b. All tested parameters were defined as non‐negative and bounded. Then, based on experimental data, the function of the fmincon equation was employed to estimate the approximate range of each parameter. These calculations were confirmed by qPCR and Western blot. The correlation coefficient (R) between model simulation and experimental data (72 hours, in intervals of 6 hours) of every variable was >0.988. The analysis of reliability and predictive accuracy depending on qPCR and Western blot data showed high predictive accuracy of the model; R was >0.988. Using the model calculations, kynurenine (x3, a6), GPR35 (x4, a8), NF‐kβp105 (x7, a16), and NF‐kβp65 (x8, a18) were recognized as sensitive targets in the Kynp. These predicted targets were confirmed by testing gene and protein expression responses. Therefore, this study provides new interdisciplinary evidence for Kynp‐sensitive targets in the treatment of PDAC.
The suggestion that landscapes should contain 40% of forest cover lacks evidence and is problematic
Authors: Banks‐Leite Cristina , Larrosa Cecilia , Carrasco Luis R. , Tambosi Leandro R. , Milner‐Gulland E. J. 
Published: February 2021

AbstractA recent review suggests that forest cover needs to be restored or maintained on at least 40% of land area. In the absence of empirical evidence to support this threshold, we discuss how this suggestion is unhelpful and potentially dangerous. We advocate for regionally defined thresholds to inform conservation and restoration.
The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
Authors: Bennett Kelly L. , McMillan W. Owen , Loaiza Jose R. 
Published: February 2021

AbstractLocal adaptation is important when predicting arthropod‐borne disease risk because of its impacts on vector population fitness and persistence. However, the extent that vector populations are adapted to the environment generally remains unknown. Despite low population structure and high gene flow in Aedes aegypti mosquitoes across Panama, excepting the province of Bocas del Toro, we identified 128 candidate SNPs, clustered within 17 genes, which show a strong genomic signal of local environmental adaptation. This putatively adaptive variation occurred across fine geographical scales with the composition and frequency of candidate adaptive loci differing between populations in wet tropical environments along the Caribbean coast and dry tropical conditions typical of the Pacific coast. Temperature and vegetation were important predictors of adaptive genomic variation in Ae. aegypti with several potential areas of local adaptation identified. Our study lays the foundations of future work to understand whether environmental adaptation in Ae. aegypti impacts the arboviral disease landscape and whether this could either aid or hinder efforts of population control.
Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors
Authors: Alim Karima , Moreau Amélie , Bruyère Arnaud , Jouan Elodie , Denizot Claire , Nies Anne T. , Parmentier Yannick , Fardel Olivier 
Published: February 2021

AbstractOrganic cation transporter (OCT) 3 (SLC22A3) is a widely expressed drug transporter, handling notably metformin and platinum derivatives, as well as endogenous compounds like monoamine neurotransmitters. OCT3 has been shown to be inhibited by a few marketed tyrosine kinase inhibitors (TKIs). The present study was designed to determine whether additional TKIs may interact with OCT3. For this purpose, the effects of 25 TKIs toward OCT3 activity were analyzed using OCT3‐overexpressing HEK293 cells. 13/25 TKIs, each used at 10 µM, were found to behave as moderate or strong inhibitors of OCT3 activity, that is, they decreased OCT3‐mediated uptake of the fluorescent dye 4‐(4‐(dimethylamino)styryl)‐N‐methylpyridinium iodide by at least 50% or 80%, respectively. This OCT3 inhibition was correlated to some molecular descriptors of TKIs, such as the percentage of H atoms and that of cationic forms at pH = 7.4. It was concentration‐dependent, notably for brigatinib, ceritinib, and crizotinib, which exhibited low half maximal inhibitory concentration (IC50) values in the 28–106 nM range. Clinical concentrations of these three marketed TKIs, as well as those of pacritinib, were next predicted to inhibit in vivo OCT3 activity according to regulatory criteria. Cellular TKI accumulation experiments as well as trans‐stimulation assays, however, demonstrated that OCT3 does not transport brigatinib, ceritinib, crizotinib, and pacritinib, thus discarding any implication of OCT3 in the pharmacokinetics of these TKIs. Taken together, these data suggest that some TKIs may act as potent inhibitors of OCT3 activity, which may have consequences in terms of drug–drug interactions and toxicity.
Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein
Authors: Marinko Marija , Hou Hai‐Tao , Stojanovic Ivan , Milojevic Predrag , Nenezic Dragoslav , Kanjuh Vladimir , Yang Qin , He Guo‐Wei , Novakovic Aleksandra 
Published: February 2021

AbstractHydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels is vasodilation. As the mechanism of H2S‐induced relaxation in human vessels remains unclear, the present study aimed to investigate the effects of H2S donor, sodium hydrosulfide (NaHS), on isolated human saphenous vein (HSV) and to determine the mechanism of action. Our results showed that NaHS (1 µM–3 mM) induced a concentration‐dependent relaxation of endothelium‐intact HSV rings pre‐contracted by phenylephrine. Pre‐treatment with L‐NAME, ODQ and KT5823 significantly inhibited NaHS‐induced relaxation, while indomethacin induced partial inhibition. Among K+ channel blockers, the combination of apamin and TRAM‐34 significantly affected the relaxation produced by NaHS, while iberiotoxin and glibenclamide only reduced maximal relaxation of HSV. NaHS partially relaxed endothelium‐intact rings pre‐contracted by high K+, as well as phenylephrine‐contracted rings in the presence of nifedipine. Additionally, the incubation of HSV rings with NaHS increased NO production. These results demonstrate that NaHS produces the concentration‐ and endothelium‐dependent relaxation of isolated HSV. Vasorelaxation to NaHS probably involves activation of NO/cGMP/PKG pathway and partially prostacyclin. In addition, different K+ channels subtypes, especially SKCa and IKCa, as well as BKCa and KATP channels in high concentrations of NaHS, probably participate in the NaHS‐induced vasorelaxation.
A MODEL OF COLLATERAL: ENDOGENIZING THE BORROWING CONSTRAINT
Authors: Awaya Yu , Fukai Hiroki , Watanabe Makoto 
Published: February 2021

AbstractThis article presents a simple equilibrium model in which collateralized credit emerges endogenously. In a frictional world, where commitment is limited and agent's actions are not publicly observable, we show that collateral can serve as a credible device that prevents the participating parties from reneging. Our theory provides a microfoundation to justify the borrowing constraints that are widely used in the existing macroeconomic models. Using the model, we explain the payment puzzle. We also show that some assets are more suitable as collateral than others with different physical properties, for example, storable asset versus durable asset.
RETRACTED: Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro
Authors: Shi Xingyuan , Luo Xueping , Chen Ting , Guo Wei , Liang Chanjin , Tang Sihan , Mo Jianming 
Published: February 2021

AbstractLung cancer is one of the major cause for high‐death rate all over the world, due to increased metastasize and difficulties in diagnosis. Naringenin is naturally occurring flavonoid found in various fruits including tomatoes, citrus fruit and figs. Naringenin is known to have several therapeutic effects including anti‐atherogenic, antimicrobial, anti‐inflammatory, hepatoprotective, anticancer and anti‐mutagenic. The present study was aimed to analyse the naringenin induced anti‐proliferative and apoptosis effects in human lung cancer cells. Cells were treated with various concentrations of naringenin (10, 100 & 200 µmol/L) for 48 hours. Cisplatin (20 µg/mL) was used as positive control. Cell viability, apoptosis, migration and mRNA, and protein expression of caspase‐3, matrixmetallo proteinases‐2 (MMP‐2) and MMP‐9 were determined. The cell viability was 93.7 ± 7.5, 51.4 ± 4.4 and 32.1 ± 2.1 at 10, 100 and 200 µmol/L of naringenin respectively. Naringenin significantly increased apoptotic cells. The 100 and 200 µmol/L of naringenin significantly suppressed the larger wounds of cultured human cancer cells compared with the untreated lung cancer cells. Naringenin increased d the expression of caspase‐3 and reduced the expression of MMP‐2 and MMP‐9. Taking all these data together, it is suggested that the naringenin was effective against human lung cancer proliferation, migration and metastasis.
Bioenergetic analysis of aged‐phenotype skin in a rare syndromic cutis laxa
Authors: Nabavizadeh Nasrinsadat , Shboul Mohammad , Hojati Zohreh 
Published: February 2021

AbstractBackgroundSkin aging is an inevitable phenomenon characterized by wrinkled skin and loss of elasticity. To date, several studies have been performed on skin aging to discover the underlying mechanisms and improve efficient preventive strategies and anti‐aging therapeutics.AimsHere, we aimed to investigate the modifications of oxidative phosphorylation and glycolysis which are the critical determinants of aging in aged‐phenotype skin.MethodsDue to the complexity of the skin aging process, we performed bioenergetic measurements on aged‐phenotype fibroblasts from an inherited cutis laxa syndrome which remarkably presents clinical features of normal aged skin. Bioenergetic analysis was performed on cutis laxa samples (n = 3) and healthy samples (n = 3) using Seahorse XFe24 Analyzer. We also compared the sensitivity of cultured aged‐phenotype fibroblasts to normal cells in glucose withdrawal.ResultsOur results show a significant increase in oxidative phosphorylation parameters but not glycolysis in the patient fibroblast cells implying increased energy demand and preferential dependence on mitochondrial respiration in those cells. Interestingly, we found the patient cells demonstrate hypersensitivity to glucose starvation, supporting their enhanced energy consumption.ConclusionsIn summary, our work suggested increased energy demand and higher oxidative phosphorylation in aged‐phenotype cells which can be considered in anti‐skin aging therapeutic design.
Long‐term outcomes of transvaginal ultrasound‐guided aspiration versus traditional conservative surgery as treatment for endometriomas: A retrospective study of cohorts
Authors: Acién Pedro , Velasco Irene , Quesada José A. , Acién Maribel 
Published: February 2021

AbstractAimTo evaluate if the long‐term results (on fertility, need of hysterectomy and persistence of endometriosis) after a minimally invasive intervention (transvaginal ultrasound‐guided puncture‐aspiration [TUGPA]) for endometriomas are significantly different from performing the traditional conservative surgery (CS) by laparoscopy or laparotomy.MethodsWe performed a retrospective study of cohorts on patients undergoing surgery for ovarian endometriomas between January 1998 and April 2015. Cohort 1 consisted of 75 women whose first intervention for endometriomas had been TUGPA. For the cohort 2, we selected a randomized paired case in which the first operation for endometriomas had been CS by laparoscopic or laparotomy (another set of 75 patients).ResultsThere were significantly more recurrences and the time to recurrence and repetition of operations were also significantly shorter in patients with TUGPA. However, there were no significant differences in overall pregnancy/delivery outcomes, in hysterectomy performances, or in endometriosis persistence at the last follow‐up visit. There were no significant differences related to the symptoms or to analytical presurgical values but the application of multivariate analysis with binary logistic regression to each dependent variable adjusted for age, symptoms, and presurgical analyses showed a significant risk of recurrence and reoperation of TUGPA versus CS.ConclusionsThose patients with endometriomas who underwent TUGPA (with or without associated medications) had a significant increase in recurrence and the need for reoperation. However, in the long‐term there were no significant differences in the results of pregnancy/childbirth, need for hysterectomy, or in the clinical or doubtful persistence of endometriosis.