bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembrolizumab-induced myasthenia gravis-like disorder, ocular myositis, and hepatitis: a case report
Authors: Tian Chia-Yi , Ou Yang-Hao , Chang Shih-Liang , Lin Chih-Ming 
Published: April 2021

Abstract
Introduction
Pembrolizumab and other immune checkpoint inhibitors are the emerging treatment for selected, high-grade malignancies. However, a small number of patients are unable to tolerate its adverse effects, leading to discontinuation of this potentially life-changing therapy. In this study, we present a case of high-grade urothelial carcinoma patient, who experienced neurocomplications during the first pembrolizumab administration. However, we were able to limit the adverse effect by concomitant use of low-dose oral steroids.

Case presentation
A 75-year-old Taiwanese female with high-grade urothelial carcinoma of the left ureter came to the neurology clinic with complaints of acute onset of bilateral ptosis 16 days after her first infusion of pembrolizumab. It was found that she developed complete bilateral ptosis and limited extraocular muscle movements. Myasthenia gravis-related antibodies and repetitive stimulation test were negative. We diagnosed her with pembrolizumab-induced myasthenia gravis-like disorder and myositis based on clinical symptoms and elevation of muscle enzymes. We commenced methylprednisolone pulse therapy followed by oral steroid therapy with gradual resolution of the symptoms. Three months later, the patient received a second cycle of pembrolizumab with low-dose oral steroids without any complications.

Conclusion
Pembrolizumab exerts its antitumor activity by interfering with the binding of programmed death 1 and its ligand, programmed death ligand 1. As a result, enhanced cytotoxic T cells can recognize tumor cells and induce cellular death. However, neurological complications may be severe and require prompt recognition and treatment. Our case demonstrated that concomitant use of low-dose steroids and pembrolizumab might prevent such complications.
You are mine. I see now, I'm a have to let you go.
Authors: Moten Fred , Woods Suné , Williams James Gordon 
Published: April 2021

Abstract
Critical Art Encounters offer sustained and at times meditative engagements with contemporary artworks. This Critical Art Encounter is a kind of reprise, a return to a joint performance by visual artist Suné Woods, poet and theorist Fred Moten, and musician and theorist James Gordon Williams. Titled You are mine. I see now, I'm a have to let you go, the piece was performed live at the Hammer Museum during their 2018 biennial event “Made in L.A.” This special section of liquid blackness aims to sample the fully realized collaboration and audiovisual experimentation that took place in the largely improvised art event. This Critical Art Encounter includes the intimate ecological exploration that takes place in Woods's video work; Moten's poem “the general balm,” which was written in part for the performance and later published in his book of poetry and criticism all that beauty (2019); and finally, a conversation with Erin Christovale, an associate curator at the Hammer who helped organize the event. Although not all three artists are featured (Williams's original compositions can be heard in the footage from the performance), we were fortunate to expand this creative dialogue by including a curatorial perspective. Thus we are able to consider how this work expresses liquidity as both a concern of contemporary black art and a call to the congregation.
Moving Between
Authors: Peterson Marina 
Published: April 2021

Abstract
Helium's material form is unstable, moving from gas to liquid under temperature. Lighter than air, it evades the immediacy of perception. Thinking through helium offers an approach to the entanglement of forms of matter that makes movement the locus. Helium shifts an understanding of “between” to one of motion, of phase shifts and plasticity rather than difference, in which the durability of matter—and of the human—withdraws.
Απ-εικονίσεις της Αμερικής
Authors: Ραπατζίκου Τατιανή Γ. , Γενενετζή-Μαλαθούνη Σμάτη , Δέτση Zωή , Μαυρέλος Νικόλαος , Καλογεράς Γιώργος , Θεοδοσιάδου Γιούλη , Κοκκώνης Μιχάλης , Δημακοπούλου Σταματίνα , Γερόλυμπος Γιώργης 
Published: April 2021

Επιμελήτριες τόμου: Τατιανή Γ. Ραπατζίκου και Σμάτη Γεμενετζή-Μαλαθούνη
Ο παρών τόμος αποτελεί τη συλλογή ενός εισαγωγικού κειμένου, έξι δοκιμίων και ενός φωτογραφικού οδοιπορικού, τα οποία επιχειρούν να σκιαγραφήσουν την εικόνα της Αμερικής από το 19ο αιώνα μέχρι σήμερα όπως αυτή προσλαμβάνεται μέσω διαφόρων λογοτεχνικών, θεατρικών, κινηματογραφικών, ποιητικών και φωτογραφικών αναζητήσεων.
Volume Editors: Tatiani G. Rapatzikou and Smatie Yemenedzi-Malathouni
Each one of the essays contained in the current volume sheds light on America's image with attention paid to particular socio-cultural events and temporalities starting from the nineteenth century till the present day as these are explored via literary practice, theater, poetry, cinema and photography.
Family Relationships and Their Associations With Perceptions of Family Functioning in Mothers of Children With Intellectual Disability
Authors: Langley Emma , Totsika Vasiliki , Hastings Richard P. , Bailey Tom 
Published: April 2021

Abstract
We explored whether reports of three dyadic relationships (marital/partner, parent-child, sibling) were related to perceptions of family functioning in 467 mothers of children with intellectual disability aged 4–15 years. Structural equation models were fitted to examine associations between relationship indicators and family functioning. The final structural model showed that partner relationship satisfaction, partner disagreement, child-parent conflict, and sibling relationship warmth accounted for the most variance in family functioning, with partner relationship satisfaction having the strongest positive association. Dimensions of dyadic relationships appear to be associated with broader constructs of family functioning in this sample of mothers, signifying the potential for systemic intervention.
Left ventricular systolic function impairment in children after balloon valvuloplasty for congenital aortic stenosis assessed by 2D speckle tracking echocardiography
Authors: Godlewski Krzysztof , Dryżek Paweł , Sadurska Elżbieta , Werner Bożena 
Published: April 2021

AimsThe aim of the study was to evaluate left ventricular (LV) remodeling and systolic function using two-dimensional speckle tracking echocardiographic (2D STE) imaging in children at a long-term (more than 36 months, 107.5±57.8 months) after balloon valvuloplasty for aortic stenosis (BAV).Methods and results40 patients (mean age 9,68 years, 75% male) after BAV and 62 control subjects matched to the age and heart rate were prospectively evaluated. The 2D STE assessment of LV longitudinal and circumferential strain and strain rate was performed. Left ventricular eccentric hypertrophy (LVEH) was diagnosed in 75% of patients in the study group. Left ventricular ejection fraction (LVEF) was normal in all patients. In study group, global longitudinal strain (GLS), global longitudinal strain rate (GLSr) were significantly lower compared with the controls: GLS (-19.7±2.22% vs. -22.3±1.5%,P< 0.001), GLSr (-0.89±0.15/s vs. -1.04 ±0.12/s,P< 0.001). Regional (basal, middle and apical segments) strain and strain rate were also lower compared with control group. Global circumferential strain (GCS), global circumferential strain rate (GCSr) as well as regional (basal, middle and apical segments) strain and strain rate were normal. Multivariable logistic regression analysis included: instantaneous peak systolic Doppler gradient across aortic valve (PGmax), grade of aortic regurgitation (AR), left ventricular mass index (LVMI), left ventricular relative wall thickness (LVRWT), left ventricular end-diastolic diameter (LVEDd), peak systolic mitral annular velocity of the septal and lateral corner (S’spt, S’lat), LVEF before BAV and time after BAV and showed that the only predictor of reduced GLS was LV eccentric hypertrophy [odds ratio 6.9; (95% CI: 1.37–12.5),P= 0.045].ConclusionPatients at long-term observation after BAV present the subclinical LV systolic impairment, which is associated with the presence of its remodeling. Longitudinal deformation is the most sensitive marker of LV systolic impairment in this group of patients.
The closure of the Vardar ocean (the western domain of the northern Neotethys) from early Middle Jurassic to Paleocene time, based on surface geology of eastern Pelagonia and the Vardar zone, biostratigraphy, and seismic-tomographic images of the mantle below the Central Hellenides
Authors: Scherreiks Rudolph , Boudagher-Fadel Marcelle 
Published: April 2021

Seismic tomographic images of the mantle below the Hellenides indicate that the Vardar ocean probably had a composite width of over 3000 kilometres. From surface geology we know that this ocean was initially located between two passive margins: Pelagonian Adria in the west and Serbo-Macedonian-Eurasia in the east. Pelagonia was covered by a carbonate platform that accumulated, during Late Triassic to Early Cretaceous time, where highly diversified carbonate sedimentary environments evolved and reacted to the adjacent, converging Vardar ocean plate. We conceive that on the east side of the Vardar ocean, a Cretaceous carbonate platform evolved from Aptian to Maastrichtian time in the forearc basin of the Vardar supra-subduction volcanic arc complex.
The closure of the Vardar ocean occurred in one episode of ophiolite obduction and in two episodes of intra-oceanic subduction.
Work in Progress: Ein Landeskonzept für den Originalerhalt des schriftlichen Kulturguts in Berlin!
Authors: Graf Lisa 
Published: April 2021

Zusammenfassung
Seit Januar 2020 widmet sich das Kompetenzzentrum Bestandserhaltung für Archive und Bibliotheken in Berlin und Brandenburg im Auftrag der Senatsverwaltung für Kultur und Europa einem weiteren wichtigen Projekt: der Erarbeitung eines Landeskonzepts für den Originalerhalt des in Berlin befindlichen schriftlichen Kulturerbes. Grundlage sind die im Rahmen einer groß angelegten zweiteiligen Erhebung in zahlreichen Kulturgut bewahrenden Einrichtungen gewonnenen Daten. Der fragebogenbasierte erste Teil begann nach intensiver Vorarbeit schließlich im Oktober 2020. Die interviewgestützte zweite Erhebungsphase wird im April 2021 starten.
Estimates on derivatives of Coulombic wave functions and their electron densities
Authors: Fournais Søren , Sørensen Thomas Østergaard 
Published: April 2021

Abstract
We prove a priori bounds for all derivatives of
non-relativistic Coulombic
eigenfunctions ψ, involving negative powers of the distance to
the singularities of the
many-body potential. We use these to derive bounds for all
derivatives of the corresponding one-electron densities ρ,
involving negative powers of the distance from the nuclei. The results
are both natural and optimal, as seen from the ground state of Hydrogen.
Failure Extropy, Dynamic Failure Extropy and Their Weighted Versions
Authors: Kayal Suchandan 
Published: April 2021

Abstract
Extropy was introduced as a dual complement of the Shannon entropy.
In this investigation, we consider failure extropy and its dynamic version.
Various basic properties of these measures are presented.
It is shown that the dynamic failure extropy characterizes the distribution function uniquely.
We also consider weighted versions of these measures.
Several virtues of the weighted measures are explored.
Finally, nonparametric estimators are introduced based on the empirical distribution function.
Price and Income Elasticities of Natural Gas Demand in Egypt: A Bound Test Approach
Authors: Farag Markos , Zaki Chahir 
Published: April 2021

AbstractThis paper provides short and long-run estimates of price and income elasticities of Egypt’s natural gas demand using the ARDL bounds testing approach to cointegration over the period 1983–2015. The results show that the long-run income and price elasticities, in absolute values, are greater than their counterparts in the short run. This result is due to the fact that consumers can modify their consumption habits and plans in the long run as a response to changes in the income or the price. Moreover, natural gas demand is more responsive to changes in income than changes in price in both the short and long run. Finally, the study examines the causality relationship between natural gas consumption and economic growth for the gas-consuming sectors in Egypt. The results indicate that there is no causal relationship between the two variables for the electricity, petroleum, and household sectors in the short-run. By contrast, there is a unidirectional causality running from natural gas consumption to the economic activity of the transportation sector and a unidirectional causality running from economic activity to natural gas consumption by the industry sector.
Optimization of drilling performance using various metaheuristics
Authors: Alsamia Shaymaa , Ibrahim Dhorgham S. , Ghafil Hazim N. 
Published: April 2021

AbstractThe most crucial function in drilling wells is the rate of penetration, which is modeled by many researchers, and the best one is Young-Bourgyen model, which is used in this study. Eight factors affecting rate of penetration have been studied and approved in developing a mathematical equation that shows the combined effects of these variables on rate of penetration optimization. This paper presents an efficient way to find the optimum values for parameters of the Young-Bourgyen model using metaheuristic algorithms. An actual drilling data was used from Khangiran field to calculate the difference between the actual penetration rate and the predicted one by different optimization algorithms. Particle swarm optimization, dynamic differential annealing optimization, artificial bee colony, gray wolf optimization, Harris hawk's optimization, flower pollination algorithm, firefly algorithm, whale optimization algorithm, and sine cosine algorithm are used to find best possible solution.
Produksi dan Pemurnian Xilooligosakarida dari Xilan Tongkol Jagung menggunakan Xilanase Streptomyces P26B4 dan Khamir IP4
Authors: Susantri Andika , Sunarti Titi Candra , Meryandini Anja 
Published: April 2021

Xylooligosaccharides (XOS) are sugar oligomers from xylan that can be used as prebiotics to improve digestive tract health. Xylan can be extracted from corncobs which are a by-product of agriculture. The purpose of this study was to produce XOS through hydrolysis of corn cobs xylan using Streptomyces P26B4 xylanase. The products of hydrolysis also consisted of monomer xylose; for that xilooligosaccharides were purified using yeast IP4. The xylan hydrolysis products are quantitatively analyzed based on the value of reducing sugars and degree of polymerization (DP), strengthened qualitatively with TLC. Sugar component was analyzed after the addition of yeast by HPLC. P26B4 xylanase isolates had the highest activity on the 7th day incubation, pH 5,5 buffer citrate and temperature of 50°C. The lowest DP value of xylan hydrolysis was 2.49 at a concentration of 6%, and the 24th hour of incubation. TLC chromatograms showed that xylose and XOS products were produced. Purification of XOS at 6%, showed a decreasing in the area of xylose before and after receiving yeast respectively 1.87% and 1.41%.Therefore, yeast IP4 has the potential to consume xylose amnd purify the XOS.
Keywords: corncobs xylan, IP4 yeast, purification, Streptomyces P26B4 xylanase, xylooligosaccharides
Investigating the English needs of law department students in English for specific purposes
Authors: Rumalessin Ummu Artha Tsary , Farah Rafika Rabba 
Published: April 2021

This present study aims at investigating the students’ target needs in learning ESP Speaking of Law department students. The adapted version of Aliakbari & Boghayeri’s (2014) and Alsamadani’s (2017) questionnaire was used as the main instrument of this study to understand the 45 students’ perception about their needs in learning ESP speaking course. A mixed-method research design was implemented in this present research. Students’ responses were analyzed statistically using SPSS 16.0 by calculating the mean, frequency and percentage. To elicit more understanding on the topic, interview was implemented to senior students in order to get deeper investigation about students’ target needs. The interview data were then analyzed using NVivo 12 Plus. This study reveals that most of the students’ needs are concerned with their professional job in the future so they are able to use English in their fields. Thus, this study provides some highlighting points on what to include in course development. In such a notion, this study suggests lecturers provide specific materials related to law in order to face their professional life either in short- or long-term future needs.
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HIGHLIGHTS:

This study pinpoints the result of Law students measurement on their self-rating towards their English competences.
This study highlights on materials related to Law department that are perceived to be strongly needed and less needed.
This study also reveals that according to students’ interview transcript, their needs in learning ESP are found to attain long-term goal compared to the short-term one.
Developing e-learning media in grammar instruction for beginner learners
Authors: Afidah Nurul , Hanifah  , Alkhoyyath Dliyauddin 
Published: April 2021

The present study intended to develop E-learning media in teaching grammar for beginner learners. In developing the product, this study adapted the ADDIE model. The product that was developed using construct application focused on part of speech material. Thirty students of sixth grade enrolled on the implementation phase. Before implemented the product, some experts gave some suggestions and critics related to the quality of the product. The final product consists of some explanations of part of speech along with exercises, and in each exercise it is provided direct feedback whether the answer is right or wrong. On the first slide, a cover is displayed with attractive and colorful background since the target learner is beginner. The language used in this product is fully in English to habituate the learners with English environment. For the back sound, the researcher used rhythm only, not a song to avoid disturbing the learners. The researcher provides learning objectives. In this case there are three learning objectives. Then on the next slide it is showed eight part of speech that will be explained in detail. In material the researcher provided the definition and kinds of part of speech, also the example of part of speech. Moreover, the exercises were created in various types, ten questions in multiple choice and five questions in jumble word. This media can be used by anyone who needs it, and another researcher can develop similar media in different topic or level.
HIGHLIGHTS:

E-learning media that is implemented optimally can help the teacher in achieving learning objectives.
E-learning media can be used as an alternative media during class instruction especially grammar instruction.
In this digital era, the teacher is demanded to habituate to use e-learning media during class instruction.
Prediction of Field Saturations Using a Fully Convolutional Network Surrogate
Authors: Zhang Kai , Wang Yanzhong , Li Guoxin , Ma Xiaopeng , Cui Shiti , Luo Qin , Wang Jian , Yang Yongfei , Yao Jun 
Published: April 2021

Summary
We are interested in the development of surrogate models for the prediction of field saturations using a fully convolutional encoder/decoder network based on the dense convolutional network (DenseNet; Huang et al. 2017), similar to the approaches used for image/image-regression tasks in deep learning. In the surrogate model, the encoder network automatically extracts the multiscale features from the raw input data, and the decoder network then uses these data to recover the input image resolution at the output of the model. The input of multiple influencing factors is considered to make our surrogate model more consistent with the physical laws, which has achieved good results in the prediction of output fields in our experiments. Various reservoir parameters including the static reservoir properties (i.e., permeability field) and dynamic reservoir properties (i.e., well placement) are used as input features, and the water-saturation distributions in different periods are taken as the output. Compared with traditional numerical reservoir simulation, which has a high computational cost and is time consuming, not only does it present the same precision, but it costs less time. At the same time, it can also be used for production optimization and history matching.
Comparative Study on Predicting Particulate Matter (PM2.5) Levels Using LSTM Models
Authors: Balamurali R. , Pachaivannan Partheeban , Elamparithi P. Navin , Hemamalini R. Rani 
Published: April 2021

Abstract
In recent times, air pollution has attracted the attention of policymakers and researchers as an important issue. The pollution that contaminates the air that people breathe is from pollutants such as oxides of carbon, nitrogen and sulphur as well minuscule dust particle which are smaller than 0.0025mm in diameter. The emissions contain many substances that are harmful to human health when exposed to them for a prolonged period or more than certain levels of concentration. The recent advent of technology in sensors and compact instruments to measure the concentration of pollutant levels with considerable ease. Further, this paper also predicts the air pollution for using multiple Deep Learning models that are variations of the Long Short-Term Memory (LSTM) model. In this research, only PM2.5 alone taken into consideration for prediction. Real-time air quality data were collected at selected places in the study area. It is found that the model prediction data is well matched with the other researchers' results and real-time data.
Construction of intimately coupled mesoporous Al2O3 nanosphere deposited 2D CdO with boosted charge separation, visible-light photocatalysis and bactericidal applications
Authors: B Janani , Khan S. Sudheer 
Published: April 2021

Abstract
Pristine Al2O3 and CdO are known to possess poor photocatalytic activity individually. The formation of CdO/Al2O3 heterojunction was investigated for the enhancement of photocatalytic performance. High resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) has been used to determine the crystalline feature and elemental composition of the NCs respectively . Peaks ascribed to Cd-O and O-Al-O was noted in fourier-transform infrared spectroscopy (FTIR) analysis. The NCs exhibits a high surface area (27.23 m2/g) to their contributing particles which was analysed using BET analyser. The band gap energy of CdO/Al2O3NCs was observed to be 2.95 eV which shows a considerable energy shift from its individual particles, CdO (2.73 eV) and Al2O3 (3.94 eV). The results displayed that the degradation efficiency of the CdO-Al2O3 NCs was enhanced 14 times than pristine Al2O3 and 3.5 times than pristine CdO. The MB dye has showed the half life period of 80 min. TOC analysis of degraded product supported high mineralization of the pollutants. The dye degradation was driven by OH. radicals and the CdO-Al2O3 nanocomposite possessed high reusability which was confirmed by six cycle test. Growth inhibition of E. coli, P. aeruginosa and B. subtilis was attained by exposure to CdO/Al2O3 NCs. The CdO-Al2O3 NCs can be a viable solution for degradation of organic contaminants effectively under natural sun light as well as an efficient antibacterial agent.