bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of nicotinamide adenine dinucleotide (NAD) for management of root-knot nematode in tomato
Authors: Regmi Homan , Abdelsamad Noor , DiGennaro Peter , Desaeger Johan 
Published: November 2021

Abstract
Nicotinamide adenine dinucleotide (NAD) has been shown to induce plant defense responses to different plant pathogens, including reducing northern root-knot nematode, Meloidogyne hapla, penetration and increasing plant mass in tomato. We wanted to further evaluate NAD that are effective against the more economically important species, M. incognita and whether NAD treatments of tomato seedlings in transplant trays can protect plants in the field. Different NAD concentrations (1  mM, 0.1  mM and 0.01  mM) and three application timings (pre; post; pre and post inoculation) were evaluated in growth room and greenhouse trials. The highest tested NAD concentration (1  mM) suppressed second-stage juveniles (J2) infection for all three application methods. Root gall ratings at 30 days after inoculation (DAI) were also suppressed by 1  mM NAD compared to the other two concentrations, and egg mass number was significantly suppressed for all concentrations and application timings compared to the non-treated control. The rate of 1  mM NAD for all three application timings also improved plant growth at 30 DAI. Long-term effects of 1  mM NAD (pre, pre + post, or post applications) on nematode infection, growth and yield of tomato were evaluated in two additional experiments. All NAD applications suppressed root galls after 60 days, but only the pre + post 1  mM NAD application suppressed gall severity at 105 days, as well as suppressed egg counts by 50% at 60 DAT. No significant difference in plant biomass and fruit yield after 105 days was observed among the treatments. Two field trials were conducted in spring and fall 2020 using tomato seedlings (cv. HM 1823) treated with two different NAD concentrations (1  mM and 5  mM in spring; 5  mM and 10  mM in fall) and transplanting seedlings in fumigated (chloropicrin  ±  1,3-dichloropropene) and non-fumigated plastic-mulch beds. No significant impact of NAD in terms of reducing RKN severity or overall tomato growth and production was seen in fumigated beds, but in non-fumigated beds 5  mM NAD slightly increased early fruit yield in spring, and 10  mM NAD reduced root-knot soil populations in fall.
Astragalus hamosus Acts as an Insulin Sensitizer in the Treatment of Polycystic
Ovary Syndrome Rat Models by Affecting IRS1 Expression
Authors: Nejati Amir , Shahri Maryam Parvini Kohneh , Farahvash Tarlan 
Published: November 2021

Background:
Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality
among women of reproductive age. Insulin resistance is known as the hallmark of PCOS
that leads to hyperinsulinemia and type 2 diabetes in PCOS patients.

Objective:
This study aimed to evaluate the expression pattern of IRS1 as a candidate gene in insulin
resistance development in the PCOS rat models.

Methods:
In this study, estradiol valerate was used for PCOS induction. Then, all of the rats were
divided into five experimental groups and treated with Astragalus hamosus extract. Ethanol was
used for extraction by Soxhlet, and extracts were analyzed by GC-MS. Ovarian morphology was
analyzed using histological experiments. Finally, the expression of IRS1 and hormonal titration of
testosterone and insulin were evaluated using qRT-PCR and ELISA assays, respectively.

Results:
Induction of PCOS led to an increase in body weight, which decreased after treatment
with the extract. Histological assessment declared an increased number of corpora lutea in treated
groups and reduced cystic follicles compared to the PCOS group. Astragalus hamosus extract-treated
groups exhibited decreased levels of insulin and testosterone compared to the PCOS group.
qRT-PCR results showed an increase in the expression levels of IRS1 in the treated groups compared
to the PCOS group.

Conclusions:
This study indicated the impact of Astragalus hamosus extract on PCOS by clarifying
the increased levels of IRS1 expression in the treated groups compared to the PCOS group.
Application of Nutraceuticals in Managing Osteoarthritis and Osteoporosis
Authors: Musyuni Pankaj , Kumar Deepak , Pandita Deepti , Jain Gaurav Kumar , Nagpal Manju , Aggarwal Geeta 
Published: November 2021

Background:
Several health problems, especially musculoskeletal disorders, are caused
by differences in work cultures and human lifestyles around the world. While the conventional approach
to treating such conditions emphasizes a balanced work-life and daily exercise, nutraceuticals
have proven to be successful. Nutraceuticals are dietary compounds that help sustain cartilage
metabolism homeostasis, reducing articular pain. Dietary intake of a variety of nutraceuticals is
thought to be essential for controlling and, more specifically, preventing osteoarthritis and osteoporosis.

Objective:
The current article offers a succinct overview in which data was gathered and searched
using specific key terms related to nutraceuticals, osteoarthritis, and osteoporosis that were available
in public domains for analysis and evaluation.

Method:
The current write-up offers a concise summary of disease and its relevance as to how
nutraceuticals are helpful, based on the defined findings and their interpretation. The present review
also discusses the existing literature, patents, and current studies in the era of nutraceuticals
for osteoarthritis and osteoporosis treatment, offering a rational basis for further investigation and
research.

Result:
This article discusses a wide variety of nutraceuticals with possible uses for osteoarthritis
and osteoporosis patients. An analysis revealed that nutraceuticals' efficacy has been established.
However, further study and investigation are needed to determine their protection.

Conclusion:
As a result of this analysis, it was concluded that more innovation and technology
transfer were required. It was also concluded that greater industry-academic collaboration was required
to begin more effective research in the treatment of osteoarthritis and osteoporosis with
nutraceuticals.
Software Engineering Frameworks Used for Serious Games Development in Physical Rehabilitation: Systematic Review
Authors: Ambros-Antemate Jorge Fernando , Beristain-Colorado María Del Pilar , Vargas-Treviño Marciano , Gutiérrez-Gutiérrez Jaime , Hernández-Cruz Pedro Antonio , Gallegos-Velasco Itandehui Belem , Moreno-Rodríguez Adriana 
Published: November 2021

Background
Serious games are a support in the rehabilitation process for treating people with physical disabilities. However, many of these serious games are not adapted to the patient’s needs because they are not developed with a software engineering framework with a set of activities, actions, and tasks that must be executed when creating a software product. Better serious games for rehabilitation will be developed if the patient and therapist requirements are identified, the development is planned, and system improvements and feedback are involved. The goal is that the serious game must offer a more attractive environment, while maintaining patient interest in the rehabilitation process.

Objective
This paper submits the results of a systematic review of serious games in physical rehabilitation identifying the benefits of using a software engineering framework.

Methods
A systematic research was conducted using PubMed, PEDro (Physiotherapy Evidence Database), IEEE Xplore, ScienceDirect, ACM Digital Library, Mary Ann Liebert, Taylor & Francis Online, Wiley Online Library, and Springer databases. The initial search resulted in 701 papers. After assessing the results according to the inclusion criteria, 83 papers were selected for this study.

Results
From the 83 papers reviewed, 8 used a software engineering framework for its development. Most of them focused their efforts on 1 or more aspects, such as data acquisition and processing, game levels, motivation, therapist supervision.

Conclusions
This systematic review proves that most of the serious games do not use a software engineering framework for their development. As a result, development systems overlook several aspects and do not have a standardized process, eventually omitting important implementation aspects, which impact the patient’s recovery time.
BERGENIA CILIATA: ISOLATION OF ACTIVE FLAVONOIDS, GC-MS ANALYSIS, ADME STUDY AND INHIBITION ACTIVITY OF OXALATE SYNTHESIZING ENZYMES
Authors: GOPHANE SHWETA R. , JADHAO SAGAR R. , JAMDHADE PREETI B. 
Published: November 2021

Objective: Bergenia ciliata (family-Saxifragaceae) is a well-known herb for kidney stone. The main objective of the study was the identification of flavonoids along with ADME profile. Another supportive objective was to check inhibition of enzymes which perform active role in oxalate synthesis.
Methods: The hydromethanolic extract was fractionated by liquid-liquid extraction to obtain ethyl acetate and ethyl ether fractions. The chemical structures of the purified compounds were identified by gas chromatography-mass spectrometry.
Results: A total of 12 volatile chemical compounds belonging to hydrocarbons, esters, alcohols, fatty acids, ketones, etc. were identified and characterized in ethyl acetate fraction through GC-MS analysis Fractions enriched in flavonoids showed glycolate oxidase and lactate dehydrogenase enzyme inhibition with IC50 value (µg/ml) 65.76 and 69.84 respectively. The kinetic behaviour of the extracts that inhibit the Glycolate oxidase and Lactate dehydrogenase activity was determined by the Lineweaver-Burk plot. The mode of inhibition of the studied plant extract was type of a non-competitive inhibition. ADMET screening of compounds successfully passed all the parameters of screening.
Conclusion: On the basis of the results, it was found that Bergenia ciliata (rhizome) may serve as a novel and rich source of therapeutic compounds and it can be further explored for urolithiasis treatment purposes.
Instituciones de desequilibrio prestacional contenidas en los principios Unidroit aplicables a los negocios jurídicos nacionales
Authors: Beltrán Valencia Gustavo Adolfo 
Published: November 2021

El presente artículo tiene por objeto analizar la viabilidad jurídica de la aplicación de las instituciones jurídicas que velan por la justicia contractual en los negocios jurídicos nacionales dada la deficiente regulación que nuestro sistema legal privado posee frente a estas circunstancias de inequidad prestacional. Se analizan instituciones como la excesiva desproporción y la excesiva onerosidad (hardship), reguladas en instrumentos pertenecientes a la lex mercatoria o derecho comercial internacional, particularmente en los principios Unidroit. Para el cumplimiento de este objetivo se realiza un estudio comparativo entre las instituciones que velan por la justicia contractual contenidas en los principios Unidroit y las contenidas en el derecho positivo privado colombiano. Además, se hace un estudio de diversos casos abordados por la justicia arbitral nacional e internacional, así como por la jurisprudencia ordinaria, frente a la posibilidad de complementación e integración de las normas de los principios Unidroit en las legislaciones nacionales.Todo lo anterior para concluir que es jurídicamente viable, a través del sistema de fuentes comercial doméstico y de los propósitos que el preámbulo de los principios Unidroit expresamente consagran, la aplicación directa a los negocios jurídicos comerciales nacionales de las figuras de la excesiva desproporción y de la excesiva onerosidad contenidas en este instrumento de derecho uniforme.
Study on energy and information-entropic measures of Hulthén potential in D dimension by an intuitive approximation to centrifugal term
Authors: Nath D , Roy Amlan 
Published: November 2021

Energy spectrum as well as various information theoretic measures are considered for Hulthén potential in D dimension.
For a given ℓ≠0 state, analytic expressions are derived, following a simple intuitive approximation for accurate representation of
centrifugal term, within the conventional Nikiforov-Uvarov method. This is derived from a linear combination of two widely
used Greene-Aldrich and Pekeris-type approximations. Energy, wave function, normalization constant, expectation value in r and p
space, Heisenberg uncertainty relation, entropic moment of order α¯, Shannon entropy, Rényi entropy, disequilibrium, majorization as
well as four selected complexity measures like LMC (López-Ruiz, Mancini, Calbert), shape Rényi complexity, Generalized Rényi
complexity and Rényi complexity ratio are offered for different screening parameters (δ). The effective potential is
described quite satisfactorily throughout the whole domain. Obtained results are compared with theoretical energies available in literature,
which shows excellent agreement. Performance of six different approximations to centrifugal term is critically discussed. An approximate
analytical expression for critical screening for a specific state in arbitrary dimension is offered. Additionally, some inter-dimensional
degeneracy occurring in two states, at different dimension for a particular δ is also uncovered.
PACS: 02.60.-x, 03.65.Ca, 03.65.Ge, 03.65.-w Keywords: Hulthén potential, Rényi complexity ratio, Statistical complexity, Majorization, Pekeris approximation, Greene-Aldrich
approximation.
The Correlation Between Students Achievement In Vocabulary And Speaking Ability at Grade 8 Junior High School Students
Authors: Zaitun Zaitun , Hadi M. Sofian , Zulfiana Rifda 
Published: November 2021

This research aimed to find out the correlation between students’ vocabulary mastery and speaking ability at grade 8 of SMP Negeri. This research was quantitative research which used correlational technique design. The sample of the research was 30 students of grade eight selected by clustering sampling. The instruments used in the research were vocabulary test and speaking test. Vocabulary test consisted of 50 questions of multiple choices, and speaking test in the form of role play. The research data were in the form of interpretation of students’ vocabulary and speaking test results, and their correlation. Based on data analysis, it was found that students’ vocabulary mastery and speaking ability were fair. They were proved by the mean score 65 for vocabulary mastery and 68 for speaking ability. Moreover, there was strong correlation between students’ vocabulary mastery and speaking ability. It was shown by the rvalue = 0,703 . Keywords:Students’ Achievement, Vocabulary, Speaking
Perilaku Seksual Remaja dengan Disabilitas Intelektual
Authors: Satryawan Bayu 
Published: November 2021

Abstract: Adolescents with intellectual disabilities are often considered not to experience sexual development like normal adolescents. This study aims to determine the description of sexual behavior that appears in adolescents with intellectual disabilities. Participants in this study were 3 adolescents with intellectual disabilities aged 19-24 years and not yet married. This study uses a qualitative method with a case study approach. The data collection process was carried out by using semi-structured interviews and observations. The results showed that the behaviors that appear in adolescents with intellectual disabilities are attraction to the opposite sex, dating, hugging and masturbating individually and with a partner. Keywords: Sexual behavior, adolescents, intellectual disabilities. Abstrak: Remaja penyandang disabilitas intelektual sering kali dianggap tidak mengalami perkembangan seksual seperti remaja normal pada umumnya. Penelitian ini bertujuan mengetahui gambaran perilaku-perilaku seksual yang muncul pada remaja dengan disabilitas intelektual. Partisipan penelitian ini adalah 3 orang remaja dengan disabilitas intelektual berusia 19-24 tahun dan belum menikah. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Proses pengambilan data dilakukan dengan wawancara semi-terstruktur dan observasi. Hasil penelitian menunjukkan perilaku-perilaku yang muncul pada remaja disabilitas intelektual adalah ketertarikan dengan lawan jenis, berpacaran, berpelukan hingga masturbasi secara sendiri dan bersama pasangan. Kata kunci: Sexual behavior, adolescents, intellectual disabilities.
Hubungan Kepribadian Neurotisme dengan Fear of Missing Out pada Remaja Pengguna Aktif Media Sosial
Authors: Astuti Chatarina Nila 
Published: November 2021

Tujuan dari penelitian ini untuk mengetahui hubungan yang positif antara kepribadian neurotisme dengan Fear Of Missing Out pada remaja pengguna aktif media sosial. Penelitian ini merupakan penelitian kuantitatif korelasional, dengan sampel penelitian sebanyak 65 responden, merupakan remaja dengan rentang usia 15-21 tahun dan aktif menggunakan media sosial selama lebih dari 2 jam/hari. Penelitian ini menggunakan Accidental sampling atau convenience sampling. Pengumpulan data dalam penelitian ini menggunakan skala Fear Of Missing Out sedangkan untuk mengukur kepribadian neurotisme menggunakan Big Five Inventory (BFI). Hasil penelitian yang didapatkan yaitu diperoleh hubungan yang positif dan signifikan antara Fear Of Missing Out dengan kepribadian neurotisme pada remaja pengguna aktif media sosial dengan korelasi positif dan signifikan (r=0, 052; Sig 0, 000). Sumbangan efektif kepribadian neurotisme berada dalam presentase 27,6%, sedangkan Fear Of Missing Out sebesar 33,6%. Remaja yang memiliki kecenderungan neurotisme sebesar 31% dalam kategori sedang dan untuk remaja dengan Fear Of Missing Out sebesar 39% dalam kategori sedang. Hasil tersebut menunjukkan semakin tinggi kepribadian neurotisme maka semakin tinggi tingkat Fear Of Missing Out pada remaja pengguna aktif media sosial.
Hubungan antara Kelekatan Aman (Secure Attachment) Orang Tua-Remaja dengan Kompetensi Sosial pada Remaja di SMPN 1 Rengasdengklok
Authors: Bela Brigita Reka 
Published: November 2021

Abstract: This study aims to examine the relationship between parent-adolescent secure attachment and social competence in adolescents at SMPN 1 Rengasdengklok. Participants in this study were 258 students of SMPN 1 Rengasdengklok, aged 13 to 15 years and living with their parents. This study uses a quantitative approach, with the Inventory of Parent and Peer Attachment (IPPA) scale measuring instrument by Armsden and Greenberg (1987) and a scale of social competence based on the aspects mentioned by Gresham and Elliot which researchers adapt and modification from research conducted by Saputra (2016). Based on the results of data analysis using non-parametric & Sperman's rho, it was obtained a correlation of r = 0.321 with a significance of 0.000 (p <0.05) indicating a significant positive relationship between parent-adolescent secure attachment and social competence in adolescents in SMPN 1 Rengasdengklok. This indicates that the higher the parent-adolescent secure attachment, the higher the social competence of adolescents will be.Keywords: Adolescence, Secure Attachment, Social CompetenceIndonesian Abstract: Penelitian ini bertujuan untuk menguji hubungan antara kelekatan aman (secure attachment) orang tua-remaja dengan kompetensi sosial pada remaja di SMPN 1 Rengasdengklok. Partisipan dalam penelitian ini yaitu siswa SMPN 1 Rengasdengklok sebanyak 258 siswa yang berusia 13 sampai 15 tahun dan tinggal bersama kedua orang tua. Penelitian ini menggunakan pendekatan kuantitatif, dengan alat ukur skala Inventory of Parent and Peer Attachment (IPPA) oleh Armsden dan Greenberg (1987) dan skala kompetensi sosial berdasarkan aspek-aspek yang disebutkan oleh Gresham dan Elliott yang peneliti adaptasi dan modifikasi dari penelitian yang dilakukan oleh Saputra (2016). Berdasarkan hasil analisis data menggunakan non-parametric & spearman’s rho diperoleh hasil koefisien korelasi sebesar r=0,321 dengan signifikansi 0,000 (p<0,05) menunjukkan adanya hubungan positif yang signifikan antara kelekatan aman (secure attachment) orang tua-remaja dengan kompetensi sosial pada remaja di SMPN 1 Rengasdengklok, menandakan bahwa semakin tinggi kelekatan aman (secure attachment) orang tua-remaja, maka kompetensi sosial pada remaja semakin tinggi juga.Kata kunci : Remaja, Kelekatan Aman, Kompetensi Sosial
PERBEDAAN RESILIENSI INDIVIDU DENGAN STATUS SOSIAL EKONOMI RENDAH DITINJAU DARI JENIS KELAMIN
Authors: Oktaverina Siska 
Published: November 2021

Penelitian ini bertujuan untuk melihat perbedaan resiliensi pada individu dengan status sosial ekonomi rendah jika ditinjau dari jenis kelamin. Resiliensi merupakan kemampuan individu untuk menghadapi tantangan, pengalaman yang sulit dan bagaimana dapat beradaptasi dalam situasi tersebut. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif. Sampel dalam penelitian ini berjumlah 89 orang yang diambil menggunakan teknik purposive sampling. Kriteria responden yang digunakan yaitu siswa/i SMP yang berusia 11-15 tahun, pendapatan orang tua di bawah Rp 1.500.000,00 dan tinggal bersama keluarga. Alat ukur yang digunakan dalam penelitian ini adalah skala resiliensi dari Maulidya (2017) dan telah diuji try out oleh Ariyati (2018), yang disusun berdasarkan teori Reivich dan Shatte (2002). Hasil perhitungan dengan menggunakan independent sample t-test memperoleh nilai signifikansi sebesar 0,017 atau p < 0,05 yang berarti terdapat perbedaan resiliensi individu dengan status sosial ekonomi rendah ditinjau dari variabel jenis kelamin. Perbedaan ini menunjukkan perempuan lebih resilien daripada laki-laki.
Konseling Perkawinan Untuk Meningkatkan Pola Komunikasi Antar Pasangan
Authors: Rahmadiani Nixie Devina 
Published: November 2021

Abstract: The purpose of this study was to resolve client complaints and prove the effectiveness of marriage counseling to improve communication patterns among couples. The research design used was a single subject research design (SSD). The subject, in this case, is a married couple who have problems related to the quality of the relationship that is not good, which is characterized by ineffective communication patterns. Before being given the intervention, the researcher conducted an assessment using the interview method, observation, family communication scale, and the couples satisfaction index (CSI) scale. The results of the assessment show that husbands and wives have different views and attitudes so that the communication pattern is not good and the partner's satisfaction score is low. The intervention used was marriage counseling for 5 sessions with the target of facilitating effective communication between the two partners. The results of the intervention showed that marriage counseling was able to improve communication patterns between husband and wife.Indonesian Abstract. Tujuan penelitian ini adalah untuk menyelesaikan keluhan klien dan membuktikan keefektifan konseling perkawinan dalam meningkatkan pola komunikasi antar pasangan. Desain penelitian yang digunakan adalah penelitian subjek tunggal atau SSD. Subjek dalam penelitian ini adalah pasangan suami istri yang mempunyai permasalahan terkait kualitas hubungan yang kurang baik, yang ditandai dengan pola komunikasi yang tidak efektif. Sebelum diberikan intervensi, peneliti melakukan penilaian dengan menggunakan metode wawancara, observasi, skala komunikasi keluarga, dan skala indeks kepuasan pasangan (CSI).Analisis dilakukan secara naratif kualitatif. Hasil penelitian menunjukkan bahwa suami dan istri memiliki pandangan dan sikap yang berbeda sehingga pola komunikasi kurang baik dan skor kepuasan pasangan rendah. Intervensi yang digunakan adalah penyuluhan pernikahan selama 5 sesi dengan target memfasilitasi komunikasi yang efektif antara kedua pasangan. Hasil intervensi menunjukkan bahwa penyuluhan perkawinan mampu meningkatkan pola komunikasi antara suami dan istri.