bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Adaptive Hybrid Discontinuous Galerkin Algorithms for Elliptic Problems
Authors: Shin Dongwook , Hwang Yoongu , Park Eun-Jae 
Published: June 2021

AbstractIn this work, we develop novel adaptive hybrid discontinuous Galerkin algorithms for second-order elliptic problems. For this, two types of reliable and efficient, modulo a data-oscillation term, and fully computable a posteriori error estimators are developed: the first one is a simple residual type error estimator, and the second is a flux reconstruction based error estimator of a guaranteed type for polynomial approximations of any degree by using a simple postprocessing. These estimators can achieve high-order accuracy for both smooth and nonsmooth problems even with high-order approximations. In order to enhance the performance of adaptive algorithms, we introduce𝐾-means clusteringbased marking strategy. The choice of marking parameter is crucial in the performance of the existing strategy such as maximum and bulk criteria; however, the optimal choice is not known. The new strategy has no unknown parameter. Several numerical examples are given to illustrate the performance of the new marking strategy along with our estimators.
Cytokine release by human bone marrow stromal cells isolated from osteoarthritic and diabetic osteoarthritic patients in vitro
Authors: Loh Kar Wai , Shaz Norshazliza , Singh Simmrat , Malliga Raman Murali , Balaji Raghavendran Hanumantha Rao , Kamarul Tunku 
Published: June 2021

Abstract

Objectives
Primary Osteoarthritis (OA) is a disease of progressive joints degeneration due to idiopathic causes. Recent evidence showed a positive relationship between OA and metabolic syndrome. This pilot study aimed to assess the baseline level of pro and anti-inflammatory cytokines in OA patients with or without Diabetic Mellitus (DM) and assess the effect of hydrogen peroxide (H2O2) in cytokine production.

Methods
Patients with primary hip and knee OA were recruited, and 3 mL of bone marrow was harvested during joint replacement surgery. Bone marrow stromal cells (BMSC) was isolated and cultured in a culture flask for three passages. Later experiment was then sub-cultured in a well plate labeled as the control group and H2O2 (0.1 mM) treated group. ProcartaPlex® Multiplex Immunoassay was performed to measure cytokine levels produced by the BMSC at 0 h, as well as 72 h.

Results
Cytokines such as tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-1β generally exhibited higher cytokine levels in subjects with DM than in nonDM subjects at 0 and 72 h. For IL-17, its expression was similar in nonDM and DM groups at 0 and 72 h. Cytokine IL-10 showed no significant difference in both the groups while DM and nonDM groups treated with H2O2 showed decreased IL-4 levels compared to control groups at 72 h. Bone marrow cells from DM-OA are more vulnerable to chemical insult and are associated with higher levels of proinflammatory cytokines production and lower IL-4 level production.

Conclusions
This study provides a clue that management of OA with co-morbidity like DM needs future studies.
Effect of steel fiber on impact resistance and durability of concrete containing nano-SiO2
Authors: Zhang Peng , Zhang Hongsen , Cui Guo , Yue Xiaodong , Guo Jinjun , Hui David 
Published: June 2021

Abstract
Impact drop weight tests, rapid chloride migration coefficient tests, single-sided freeze–thaw tests, and mechanical property tests were performed to investigate the effect of the steel fiber (SF) content on the impact resistance and durability of concrete containing nano-SiO2 (NS). A fixed NS content of 3% and six SF contents in a range of 0–2.5% by volume were used. The impact resistance was measured based on the number of blows (N1, N2) and the impact energy. The durability of concrete includes its freeze–thaw resistance and chloride ion penetration resistance, which were appraised by the chloride ion diffusion coefficient (CDC) and relative dynamic elastic modulus (RDM), respectively. The ductility ratio was used to predict the impact resistance of concrete containing NS with different SF contents, and a linear relation between this ratio and the impact energy (R
2 = 0.853) was found. The experimental results indicated that SF could greatly improve the impact resistance of concrete. The addition of 2.0% SF increased N1 and N2 by 106 and 169%, respectively. In addition, an appropriate SF content significantly improved the durability of the concrete, including its frost resistance (especially in the middle and late freezing–thawing cycles) and chloride ion penetration resistance. An SF content of 1.5% was the optimum, decreasing the CDC of nano-concrete by 17.1% and minimizing the RDM loss. Moreover, the 1.5% SF content increased the compressive strength of concrete containing NS by 18.5%, whereas an SF content of 2.0% increased the splitting tensile strength and flexural strength by 77 and 20%, respectively. Furthermore, when the SF content exceeded a certain value, the improvement effect on these properties began to decrease and even became negative.
Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
Authors: Lahogue Caroline , Pinault Didier 
Published: June 2021

Abstract
During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies) during the wake–sleep cycle. Neural oscillations are electrobiomarkers of the connectivity state within systems. A single-systemic administration of ketamine, a non-competitive NMDA glutamate receptor antagonist, transiently reproduces the oscillopathies with a clinical picture reminiscent of the psychosis prodrome. This acute pharmacological model may help the research and development of innovative treatments against psychotic transition. Transcranial electrical stimulation is recognized as an appropriate non-invasive therapeutic modality since it can increase cognitive performance and modulate neural oscillations with little or no side effects. Therefore, our objective was to set up, in the sedated adult rat, a stimulation method that is able to normalize ketamine-induced increase in gamma-frequency (30–80 Hz) oscillations and decrease in sigma-frequency (10–17 Hz) oscillations. Unilateral and bipolar frontoparietal (FP), transcranial anodal stimulation by direct current (<+1 mA) was applied in ketamine-treated rats. A concomitant bilateral electroencephalographic recording of the parietal cortex measured the stimulation effects on its spontaneously occurring oscillations. A 5 min FP anodal tDCS immediately and quickly reduced, significantly with an intensity-effect relationship, the ketamine-induced gamma hyperactivity, and sigma hypoactivity at least in the bilateral parietal cortex. A duration effect was also recorded. The tDCS also tended to diminish the ketamine-induced delta hypoactivity. These preliminary neurophysiological findings are promising for developing a therapeutic proof-of-concept against neuropsychiatric disorders.
leyenda de Izz Al Din Al Qassam y su influencia en la insurgencia palestina
Authors: Caretti Gonzalo 
Published: June 2021

Dentro de la cultura de insurgencia armada en Palestina, la figura del clérigo Izz Al Din Al Qassam (Siria, 1883 - Palestina, 1935) es una de las más mitificadas. Líder de una revuelta armada en 1935 contra las autoridades del Mandato británico que duró a apenas veinte días, su imagen ha tenido un importante impacto en los movimientos políticos y armados posteriores y en la tradición oral de la zona. Al Qassam ha sido, desde su muerte, un habitual elemento movilizador en la cultura de resistencia contra la ocupación. Éste artículo analiza, a través de fuentes bibliográficas y archivísticas, una revisión crítica de su figura y el cómo la leyenda ha influido en las visiones actuales sobre él.
cooperación educativa no universitaria entre España y Marruecos
Authors: Zebda Siham 
Published: June 2021

La cooperación educativa no universitaria ocupa un lugar importante en la agenda bilateral hispano-marroquí como lo refleja su tratamiento en las once Reuniones de Alto Nivel celebradas entre España y Marruecos así como por los convenios y tratados firmados entre ambas partes. Esta cooperación se concreta en el Programa de Enseñanza de la Lengua Árabe y la Cultura Marroquí (LACM) en los colegios españoles y en la enseñanza del español en Marruecos, tanto en el marco del sistema educativo nacional marroquí como en la red de centros educativos españoles en Marruecos. En este trabajo pretendemos realizar una radiografía de esta cooperación haciendo un balance de los diferentes programas y propuestas recogidas en las Reuniones de Alto Nivel.
Japanese students' perceptions of the role that shadow education plays in competition in education
Authors: Fülöp Márta , Gordon Győri János 
Published: June 2021

AbstractThe relationship between shadow education and competition has been discussed and studied widely by educational experts and policy makers in Japan. One major topic has been the role that shadow education plays in social inequality by creating winners and losers. Another is related to competition and students' psychological health; and a third concerns the cause-and-effect relationships between cram/preparatory schools and competition. The present paper focuses on students' perspectives and describes an empirical study carried out with 211 Japanese senior high school students and 145 university students. The students answered open-ended questions about their cram/preparatory school attendance, and were asked to describe how they perceived the relationship between cram/preparatory schools and competition. The free descriptive answers were content-analysed and categorized. The majority of the respondents not only saw a relationship between the two but also listed a number of functions that increased students' competitive advantage. Educational experts' and sociologists' common criticism that shadow education has detrimental effect on fairness or equal chances in education was hardly at all expressed. Relatively few students expressed doubts or emphasized the negative or harmful side of cram/preparatory school attendance and competition. The results call the attention to the importance of studying different aspects of shadow education more in-depth from the direct “users'” i.e, the students' perspective as well.
The Alcaic Odes of Horace and Greek Poems of the Early 20th Century
Authors: Darwish Hisham A. 
Published: June 2021

SummaryThis article is concerned with shedding light on two examples of influence between Horace and the Greek poets, both ancient and modern. The aim of this paper is to shed light on several parallel aspects between two of the Alcaic odes of Horace and two modern Greek lyric poems by Constantine Cavafy and Angelos Sikelianos, respectively. Subsequently, I show, within the wider framework of inter-textuality, a subtle example of the utilization and re-utilization of lyric elements that are originally ancient Greek in nature by the Latin and modern Greek poets. In my argumentation, I will rely on textual similarities, as well as on the views expressed by scholars in non-comparative contexts The paper is divided into two parts. In the first part, I compare Horace’s carm. 2. 3 with Cavafy’s Ithaka. The most important points of comparison in this section are three common features: instructive tone, the epicurean tendency and the melancholic end. In the second, I compare Horace’s carm. 1. 37 with Sikelianos’ Dithyramb. The most important points of comparison in this section are three common features, namely, the connection of the Bacchic ecstasy to political issues, the connection of the Dionysiac spirit to the struggle against the national enemy and the association of Bacchic frenzy with hunting and chase.
The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes
Authors: Zhou W. , Zeng G. , Lyu C. , Kou F. , Zhang S. , Wei H. 
Published: June 2021

AbstractAimLimited investigations on metabolic responses to exercise training in female adolescent volleyball athletes exist. The aim of this study was to obtain serum and urine metabolite markers in female adolescent volleyball athletes within 2-week strength-endurance training using a metabolomics approach coupled with biochemical analysis, which would be potential biomarkers for evaluating the physiological state of athletes.MethodsTwelve female adolescent volleyball athletes were recruited for 2-week strength-endurance training. Differential serum and urine metabolic profiles between the pre- and post-training group were obtained on gas chromatography coupled to mass spectrometry (GC-MS) and data subsequently underwent orthogonal partial least-squares analysis (OPLS).ResultsStrength-endurance training exerted a significant influence on the athletes' serum and urine metabolic profiles. The changed metabolites were primarily involved in energy metabolism, lipid metabolism and amino acids metabolism. Results support the hypothesis that female athletes displayed an increased propensity to oxidize lipids as the major energy source. Exposure to strength-endurance training also led to a significant increase in cortisol, but a decrease in testosterone, indicating disordered hormone adjustment. Exercise-induced oxidative stress occurred, as was evidenced by the decrease in reduced glutathione, and increases in blood malondialdehyde and oxidized glutathione. Since the muscle damage markers creatine kinase and lactate dehydrogenase did not show significant changes, the training might not cause cell membrane damage and the athletes did not cross the adaptive injury level.ConclusionBy measurement of endogenous metabolites, the metabolomics study has the potential to reveal the global physiological changes in response to exercise training.
Associations of health status and diabetes among First Nations Peoples living on-reserve in Canada
Authors: Batal Malek , Chan Hing Man , Fediuk Karen , Ing Amy , Berti Peter , Sadik Tonio , Johnson-Down Louise 
Published: June 2021

Abstract
Objective
Our objective is to describe self-reported health status, prevalence of diabetes and obesity and their associations in participants from the First Nations Food, Nutrition and Environment Study (FNFNES) in order to identify possible correlates of health in First Nations adults.

Methods
FNFNES is a participatory study with First Nations Peoples living on reserve lands south of the 60th parallel. Health and diabetes were self-reported, and prevalence of obesity was evaluated. Socio-demographic and lifestyle factors and traditional food (TF) activities were investigated for associations with health parameters.

Results
High prevalence rates of overweight/obesity (78–91%) and diabetes (19% age-standardized prevalence) were found. Smoking rates were high and physical activity was low. In multivariable analyses, obesity was associated with region, income source, age, gender, smoking and self-reported health; diabetes and lesser self-reported health were associated with obesity and lower education. Diabetes was strongly associated with lesser self-reported health and weakly associated with being a smoker.

Conclusion
We have identified possible correlates of health in this population that can help to better understand the underlying concerns and identify solutions for First Nations and their partners. We urge governments and First Nations to address the systemic problems identified with a holistic ecosystem approach that takes into consideration the financial and physical access to food, particularly TF, and the facilitation of improved health behaviour. New mechanisms co-developed with First Nations leadership should focus on supporting sustainable, culturally safe and healthy lifestyles and closing the gaps in nutrition and food insecurity.
Nutrient adequacy and nutrient sources of adults among ninety-two First Nations communities across Canada
Authors: Batal Malek , Chan Hing Man , Ing Amy , Fediuk Karen , Berti Peter , Sadik Tonio , Johnson-Down Louise 
Published: June 2021

Abstract
Objectives
To identify food sources of nutrients in First Nations adults in Canada and to establish whether these populations are meeting their nutrient requirements and whether traditional foods (TF) contribute to better nutrient intake.

Methods
The First Nations Food, Nutrition and Environment Study is a cross-Canada participatory study of First Nations adults living south of the 60th parallel. Twenty-four-hour recalls were conducted in 92 First Nations communities from 2008 to 2016. Repeat recalls were attempted with 20% of participants to adjust for within-person variation and estimate the proportion of individuals below recommendations according to Institute of Medicine guidelines. Nutrients from days with and without TF were compared. The main food sources of select nutrients were identified, including TF.

Results
Mean energy intakes among women and men ranged from 1664 to 1864 and from 1761 to 2298 kcal/day respectively. Most macronutrients were within the acceptable macronutrient diet range except for fat in most age groups and carbohydrates in men 71 years of age and older. Saturated fat was above recommendations for all ages. Only niacin was identified as above recommendations in all age and sex categories. Days where TF were eaten showed greater intakes of key nutrients.

Conclusion
It is imperative that we find culturally appropriate ways to improve the quality and nutritional value of First Nations Peoples food intake by improving TF access and use on the one hand and conversely providing better quality store-bought foods. For success in this, we must empower First Nations communities and health practitioners to collaboratively overcome these challenges.
Metals in the drinking water of First Nations across Canada
Authors: Schwartz Harold , Marushka Lesya , Chan Hing Man , Batal Malek , Sadik Tonio , Ing Amy , Fediuk Karen , Tikhonov Constantine 
Published: June 2021

AbstractObjectivesThe First Nations Food, Nutrition and Environment Study (FNFNES), a community-based participatory research project, measured the levels of metals of health concern and the levels of metals that have operational guidance (OG) and aesthetic objectives (AO) in drinking water of First Nations (FN) south of the 60thparallel.MethodsBoth stagnant (first draw) and flushed tap water samples were collected from participating households in 91 FN representing 11 ecozones. The concentrations of metals were quantified and compared to Health Canada’s Guidelines for Canadian Drinking Water Quality (GCDWQ).ResultsIn total, 1516 FN households participated in this study component. Exceedances of the 2019 GCDWQ for the health-based maximum acceptable concentration (MAC) were found for five metals: lead 8.4% of households (first draw), manganese 4.0%, uranium 1.6%, aluminum 1.3%, and copper 0.2% (flushed). Flushing taps resulted in a decrease to 0.7% of households exceeding the lead MAC. Exceedances of the current OG for aluminum were found in 14.2% and the exceedances of the proposed OG were found in 18.1% of households (flushed). Exceedances of the AO (flushed) were as follows: manganese 12.8%, sodium 5.1%, iron 3.5%, and copper 0.4%. Results of the study were compared to provincial surveys where the data were available. Taste and colour were reported to be the main reasons for limiting the use of tap water.ConclusionOverall, the quality of drinking water with respect to trace metals of human health concern is satisfactory. However, elevated lead levels were found in some FN communities. Until appropriate action can take place, it was recommended to flush the water before use to reduce the lead levels.
Regionally representative hair mercury levels in Canadian First Nations adults living on reserves
Authors: Tikhonov Constantine , Schwartz Harold , Marushka Lesya , Chan Hing Man , Batal Malek , Sadik Tonio , Ing Amy , Fediuk Karen 
Published: June 2021

AbstractObjectiveThe primary objective of this participatory study was to assess the current body burden of mercury among First Nations adults.MethodsThe First Nations Food, Nutrition and Environment Study (2008–2018) collected regionally representative data from First Nations adults living on reserves south of the 60thparallel. Mercury was analyzed in hair as a preferred biomarker for prolonged exposure. Hair samples, a 5 mm bundle cut from the occipital region, were collected from the participants who gave consent and measured for total mercury concentrations using cold vapor atomic fluorescence spectrophotometry.ResultsIn total, 3404 First Nations adults living in 92 communities provided hair samples. This represents 52.5% of the respondents to the household surveys. The mean hair mercury concentrations were 0.56 μg/g among all participants and 0.34 μg/g among women of childbearing age (WCBA). There were 64 exceedances of Health Canada’s mercury biomonitoring guidelines (44 WCBA, 8 women aged 51+ years, 3 men aged 19–50 years, and 9 men aged 51+ years).ConclusionCurrent mercury exposure no longer presents a significant clinical health risk in most of the First Nations population south of the 60thparallel across Canada. However, mercury exposure continues to be an ongoing environmental public health concern that requires continued monitoring and assessment. Women of childbearing age (19–50 years) and older individuals living in northern ecozones and Quebec have higher mercury exposures, often exceeding Health Canada’s guidelines. Careful risk communication and risk management programs need to focus on northern ecozones and Quebec.
Gender differences in lipid metabolism
Authors: Mittova Valentina O. , Khoroshikh Anna O. , Zemchenkova Olga V. , Ryazantsev Sergey V. , Maslov Oleg V. , Korzh Elena V. , Ryasnaya-Lokinskaya Lilia S. , Alabovsky Vladimir V. 
Published: June 2021

The search for early markers of atherosclerosis is an effective method for providing personalized medicine allowing the prevention of the progression of this pathology. The aim of this study was the determination of the total indices of dyslipidemia and the identification of the gender indices of the extended lipid profile in the population of residents of the Southern and Central Federal Districts (Voronezh, Belgorod, Lipetsk, Kursk and Rostov regions) for the identification of early markers of atherogenicity. In a simultaneous clinical study, involving 339 patients (mean age 48 years), the concentrations of total cholesterol, triglycerides, LDL (low density lipoproteins), HDL (high density lipoproteins), apolipoproteins B and A1, the ApoB/ApoA1 ratio and the atherogenic coefficient were determined. For the identification of the relationship between changes in lipid profile indicators with cytolysis syndrome and indicators of carbohydrate metabolism, the activity of ALAT (alanine aminotransferase), GGTP (gamma-glutamyl transpeptidase) and glucose contentwere also studied. Analysis of the results of the lipid spectrum of the population sample of the middle age group revealed significant metabolic disorders of lipid metabolism with a predominance of atherogenic lipid fractions and a significant excess of indicators of atherogenic lipid fractions in middle-aged men in comparison with women. It has been shown that the apoB/apoA1 index can be used as an auxiliary marker for early assessment of the prevalence of atherogenic lipid fractions, allowing the identification of risk groups for the development of diseases associated with metabolic disorders