bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Maternal Betaine Supplementation on Growth, Plane of Nutrition, Blood Biochemical Profile and Antioxidant Status of Progeny Pigs
Authors: Mishra Alok , Verma A.K. , Das Asit , Singh Putan , Munde V.K. 
Published: April 2021

Background: Dietary supplementation of methyl donors like vitamins B9, B12, choline and betaine have been reported to reduce oxidative stress not only in sows but can also reduce oxidative stress in offspring through epigenetic modulation of DNA. However, cell proliferation and fetal development and oxidative stress associated with it is not uniform during the whole length of gestation. Hence this experiment was conducted to study the effects of maternal betaine supplementation on growth, plane of nutrition and antioxidant profile of progeny pigs. Methods: Eighteen crossbred (Landrace X Desi) sows were randomly distributed into three groups of six each in an experiment based on completely randomized design (CRD). The sows in control (T0) were fed standard ration to meet their requirements. Supplementary betaine at 3 g/kg DM were provided either during late pregnancy (d 76 onwards till parturition) only or throughout the length of gestation to the sows of groups T1 and T2, respectively. The samples of feed offered, residue and faeces were analyzed for proximate principles following the standard procedures. Blood samples from the progeny piglets were collected and antioxidant status of the piglets assessed by the measurement of superoxide dismutase (SOD) and catalase (CAT) by using standard kits. Result: The serum concentration of SOD was comparable (p greater than 0.05) among the groups, whereas serum concentration of catalase was higher (p less than 0.05) in piglets born to the dam exposed to supplementary beanie during gestation, the best response was observed whilst betaine was supplemented in the maternal diets during the whole length of gestation It was concluded that supplementation of betaine at 3g/kg in the diet of pregnant sows improved the antioxidant capacity of piglets borne to them.
Gender-specific patterns and determinants of spillover between work and family: The role of partner support in dual-earner couples
Authors: Ayhan Adams  , Katrin Golsch  
Published: April 2021

Objective: The study investigates how partner support affects different types of work-to-family and family-to-work conflicts in dual-earner couples divided by gender and parenthood.
Background: In Germany, as in other Western Countries, interrole conflicts between work and family increase, especially within dual-earner couples. Only few studies focused on the effects of partner support on different types of these conflicts.
Method: We use longitudinal data deriving from waves 6 to 10 of the German Family Panel (pairfam) to uncover the extent to which the perception of having a supportive partner reduces time- and strain-based work-to-family and family-to-work conflicts. We conduct longitudinal structural equation models based on information of 1,252 persons, which are full-time employed and live in a dual-earner relationship.
Results: Whereas for men partner support helps reduce stress-based work-to-family conflicts, for women perceived partner support is not beneﬁcial. Within a subsample of parents, the experience of work-to-family conflicts is likely irrespective of partner support. Overall, women’s family-to-work conflicts appear to be reduced by their partners’ support whereas for men this detrimental effect only applies in the case of stress-based family-to-work conflicts.
Conclusion: To sum up the findings, the differences for men and women in the effect of partner support on different types of interrole conflicts indicate a still existing impact of traditional gender norms that connect femininity to house work and masculinity to employed work.
Characterization of Antioxidant Compound from Syzygium polyanthum Leaves Fraction Using UHPLC-HRMS
Authors: Syabana Muhammad Ana , Yuliana Nancy Dewi , Batubara Irmanida , Fardiaz Dedi 
Published: April 2021

The leaves of Syzygium polyanthum is widely used in Indonesia as a spice. It has been reported to have significant antioxidant activity. However, the reports on compounds responsible for the activity are very scarce. The purpose of this research was to characterize the chemical profile of S. polyanthumfractions which showed the highest antioxidant activity. The dried leaves of S. polyanthum were fractionated using the different combination of non-polar to polar solvent, those are n-hexane, acetone, water. Fourteen fractions were collected and analyzed for their DPPH antioxidant activity. The chemical profile of selected fractions was characterized using UHPLC-HRMS to identify compounds that might associate with the antioxidant activity of S. polyanthum. The results showed that at the dose of 500 μg/ml, four fractions showed the highest antioxidant activity with the following order: F9 (acetone:water=80:20), F10 (acetone:water=60:40), F1 (hexane 100%) andF3 (hexane:aceton=80:20). UHPLC-HRMSanalysis successfully identified several compounds in F9 and F10. Gallic acid, pyrogallol, and myricetin were identified in F9. Aconitic acid was identified in F10. All of the identified compounds were previously reported to have antioxidant activity
Measuring Productivity and Efficiency of Traditional Chinese Medicine Hospitals from 2009 to 2016: A Bootstrap-Data Envelopment Analysis
Authors: Liu Xinliang , Chen Rui , Wu Shaopeng , Wang Jian , Li Jianan , Wang Quan , Li Hao 
Published: April 2021

Abstract
Objective: It was to estimate the productivity and efficiency of Traditional Chinese Medicine (TCM) hospitals to provide empirical evidence for hospital managers and policy-makers to improve the management and quality of TCM service.Methods: The data of the individual tertiary public TCM hospitals were collected from official Yearbooks of Traditional Chinese Medicine of China (2010-2017). Bootstrap-Malmquist-DEA was employed to measure the productivity and efficiency (2009-2016). SPSS23.0 was used to conduct the descriptive analysis of the input and output indicators. R3.2.1 was applied to calculate the productivity and efficiency with FEAR package. The statistical significance was set at P < 0.05.Results: The annual average growth rates of each indicator were 6.61% (health professionals), 8.15% (actual open beds), 7.08% (outpatients and inpatients) and 12.50% (discharged patients) respectively from 2009 to 2016. Except the total factor productivity change (TFPC) between 2014 and 2015, more than half of the TCM hospitals had TFPC scores over 1.000. The overall annual geo-mean TFPC score was 1.0379.Conclusions: The overall annual rate of the TFPC of the tertiary public TCM hospitals was slightly increased. The technological progress was the main driver to improve the total factor productivity. The decreased technical efficiency was more affected by the decreased scale efficiency. The TCM hospitals need to pay attention to the development and innovation of the TCM technology, thereby improving the competitiveness. The TCM hospitals managers should pursuit the high quality, high efficiency and low cost of the TCM services.
MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer
Authors: Quintanilha Julia C.F. , Cursino Maria A. , Borges Jessica B. , Torso Nadine G. , Bastos Larissa B. , Oliveira Juliana M. , Cobaxo Thiago S. , Pincinato Eder , Hirata Mario H. , Geraldo Murilo V. , Lima Carmen S.P. , Moriel Patricia 
Published: April 2021

Abstract
Background: No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. Methods: We performed microRNA (miRNA) sequencing using plasma collected five days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and without nephrotoxicity (grade ≥2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected for quantification at baseline and D5 in a larger cohort of patients. The association between miRNAs and nephrotoxicity was evaluated by calculating the odds ratio (OR) from univariate logistic regression. Receiver operating characteristic curves (ROC) were used to estimate the area under the curve (AUC), sensitivity, and specificity. Results: MiR-3168 (p=1.98×10−8), miR-4718 (p=4.24×10−5), and miR-6125 (p=6.60×10−5) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p=0.0456, OR=1.03, 95% CI: 1.00–1.06) and miR-4718 (p=0.0388, OR=1.56, 95% CI: 1.03–2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p=0.0618, OR=1.73, 95% CI: 0.98–3.29). MiR-4718 showed the highest AUC (0.77, 95% CI: 1.74–5.8) with sensitivity of 66.76 and specificity of 79.49. Conclusions: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
GABA Boosts Relief from Coercive Power: an fMRI study
Authors: Cheng Yawei , Martínez Róger , Chen Yu-Chun , Fan Yang-Teng , Chen Chenyi 
Published: April 2021

Abstract
Individuals under coercive control frequently suffer from anxiety, with recent research asserting this situation as a catalyst for certain types of violence directed towards those suffering under the most serious and insidious forms of coercive power –such as domestic violence victims. Studies researching this matter have skewed towards dissembling manipulation, or participants' obedience levels, neglecting the fact that agents under coercive power are also victims of coercive violence. In this functional magnetic resonance imaging (fMRI) study, we investigate the effects of the anxiolytic GABAA (gamma-Aminobutyric acid) modulator, lorazepam, on behavioral and neural levels in response to coercive power. We used a virtual obedience to authority paradigm inspired in Milgram's renowned experiments of the same nature. An experimenter ordered a volunteer to press a handheld button to initiate actions that carry different moral consequences, including harming or helping others. Our results showed that lorazepam administration, relative to placebo, slowed down reaction times when initiating harming behaviors, but accelerated reaction times for helping actions, despite comparable subjective ratings regarding perceived coercion. Coercive harming significantly increased activation in the amygdala, hippocampus, orbitofrontal cortex, and dorsolateral prefrontal cortex (dlPFC). After lorazepam administration, activity in the amygdala and hippocampus decreased, but activity in the dlPFC and right temporoparietal junction increased. The lower activity in the hippocampus predicted higher subjective ratings for perceived coercion. Furthermore, lorazepam administration significantly decreased the functional connectivity of the hippocampus with the dlPFC during coercive harming. Our results shed light on the coping strategies against coercion beyond merely examining its effects.
DNMT3A Low-Expression is Correlated to Poor Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia and Confers Resistance to Daunorubicin on Leukemic Cells
Authors: Li Weijing , Liu Shuguang , Wang Chanjuan , Cui Lei , Zhao Xiaoxi , Liu Wei , Zhang Ruidong , Li Zhigang 
Published: April 2021

Abstract
Background Little is known about DNMT3A expression and its prognostic significance in childhood B cell precursor acute lymphoblastic leukemia (BCP-ALL). MethodsWe determined DNMT3A mRNA expression in 102 children with BCP-ALL. Correlations with relapse-free survival (RFS) and common clinical characteristics were analyzed. DNMT3A was stably knocked out by CRISPR/Cas9 gene editing technology in 697 cell line. Cell proliferation activity after treated with daunorubicin was determined by CCK8 assay in DNMT3A KO 697 cell line.Results DNMT3A expression in BCP-ALL patients who were in CCR was higher than in those who got relapse (P=0.0111). Receiver operating characteristic curve showed prognostic significance of DNMT3A expression (P=0.003). Low expression of DNMT3A (<0.197) was significantly correlated with poor RFS (P<0.001) in children with BCP-ALL. Knock-out of DNMT3A in 697 cell line significantly increased IC50 of daunorubicin (P=0.0057), indicating elevated resistance to daunorubicin. ConclusionsLow expression of DNMT3A associates with poor prognosis in children with BCP-ALL. Knock-out of DNMT3A confers resistance to daunorubicin on leukemic cells.
Ex situ conservation of Cistus heterophyllus subsp. carthaginensis (Cistaceae) saves the taxon from introgression by Cistus albidus
Authors: Werner Olaf , Vicente María José , Aguado Mayra , Robles Jesús , Ros Rosa María 
Published: April 2021

Abstract
Cistus heterophyllus subsp. carthaginensis is a critically endangered plant taxon from E Spain. Only two populations, one in La Pobla de Vallbona, Valencian Community (consisting of only one plant) and the other in Llano de Beal, Cartagena municipality, Autonomous Community of the Region of Murcia, are presently known. The low number of individuals and introgression by the closely related C. albidus are the major threats to the conservation of Cistus heterophyllus subsp. carthaginensis. In the years 2007, 2008, 2011, and 2013 seeds were collected from the Murcia population within the efforts to protect this taxon. In this work, we compare the natural population of Murcia with the ex situ plants originated from the recollected seeds, the only known sample from Valencia, and a specimen of North Africa of C. heterophyllus using genotyping by sequencing. The natural population of Murcia shows clear signals of introgression by C. albidus while the ex situ plants are much less affected, suggesting that the major part of the introgression of the natural populations took place after the specimens for the ex situ collection were taken. The Murcian samples seem not to be very close to the Valencian plant, but the systematic relationships among the studied populations remain unclear. The ex situ conservation efforts are a key to the conservation of this taxon.
Removal of p-arsanilic acid and phenylarsonic acid from water by Fenton-coagulation process: influence of substituted amino group
Authors: Peng Qiang , Xu Wenze , Qi Weixiao , Hu Chengzhi , Liu Huijuan , Qu Jiuhui 
Published: April 2021

Abstract
Phenylarsonic acid compounds, which were widely used in poultry and swine production, are emerging contaminants due to their considerable solubility in water and the highly toxic inorganic arsenic species forming potential during their biotic and abiotic degradation in the natural environment. Herein, we investigated the optimal conditions to treat typical organoarsenic contaminants ( p -arsanilic acid ( p -ASA) and phenylarsonic acid (PAA)) in aqueous solution based on Fenton-coagulation process for oxidizing them and capturing the released inorganic arsenic, and elucidated the influence mechanism of substituted amino group on removal. Results showed that the pH value and the dosage of H 2 O 2 and Fe 2+ significantly influenced the performance of the oxidation and coagulation processes. The optimal conditions for removing 20mg L -1 -As in this research were: 40mg L -1 Fe 2+ and 60mg L -1 H 2 O 2 (the mass ratio of Fe 2+ /H 2 O 2 = 1.5), initial solution pH of 3.0 and final solution pH of 5.0 adjusting after 30 min Fenton oxidation reaction. Meanwhile, the substituted amino group observably influence the oxidation and coagulation performance of phenylarsonic acid compounds. Amino group could make phenylarsonic acid compounds more easily be attacked by ·HO and supply more binding sites for forming complexes with Fe 3+ hydrolysates, resulting in higher oxidation rate and better coagulation performance.
Photodegradation of methotrexate in aqueous solution: degradation kinetics and identification of transformation products
Authors: Espinosa Anaïs , Nélieu Sylvie , Lieben Pascale , Skarbek Charles , Labruère Raphaël , Benoit Pierre 
Published: April 2021

Abstract
Methotrexate is an antineoplastic folate analog of high environmental concern, due to its low biodegradability and toxicological properties. This study focused on its photodegradation under two irradiation conditions, aiming to be representative of environment (300–450 nm) and drinking water treatment (254 nm). The photodegradation experiments were conducted at two pH, to vary the methotrexate ionization state and to produce a large variety of transformation products (TPs). The degradation kinetics determined through LC-UV monitoring were contrasted according to pH and irradiation wavelength. However, the quantum yields were independent of ionization state at 254 nm and the changes in kinetics at higher wavelengths were attributed to a change in the degradation mechanism. The TPs formed during the reactions were identified by UHPLC-MS/MS, using both the positive and negative modes. Among the eleven proposed structures, five were described as methotrexate TPs for the first time. The TPs result from N-demethylation, glutamic acid oxidation and C-N cleavage, all of them leading to further degraded photoproducts presenting modified or lost glutamic acid part. This was made possible thanks to the negative mode, which allowed the exploration of the glutamic acid moiety modifications. Cytotoxicity assessment on A549 cancer cells demonstrated that all photoproducts formed at pH 7 were less toxic than the parent compound.
Title Length Variation Trends in Papers on Algorithms in IEEE Xplore
Authors: Besharati Mohammad Reza , Jafari Nafiseh , Izadi Mohammad 
Published: April 2021

Abstract
The title of any paper showcases its identity and the scientific orientation of its authors. The title length is one of the scientometrics indicators used in the statistical analysis of papers. The researchers have already found a relationship between the number of authors of a paper and its title length. In this study, we have analyzed the metadata of 19,469 papers on algorithms indexed in the IEEE Xplore database to conduct a more extensive study on this indicator and its trends, with three major findings: 1) Over time, the title lengths of the algorithm-related papers have increased, going from 70 printed letters in 1995 to 80 in 2009; 2) Papers with more authors also have longer titles; and 3) With time, as more scholars delve into the subfields of a scientific discipline, the title lengths of papers would increase. So that the peaks of the frequency charts of this variable exhibit a wave-like behavior and shift to the right.
Event-Triggered Adaptive Asymptotic Tracking Control of Flexible Robotic Manipulators: A Command Filtered Backstepping Method
Authors: Cheng Tingting , Niu Ben , Zhang Guangju , Wang Zhenhua , Duan Peiyong 
Published: April 2021

Abstract
This paper formulates an event-triggered adaptive asymptotic tracking control scheme for flexible robotic manipulators via command filtered backstepping method. Firstly, in the proposed design algorithm, the unknown nonlinear functions are firstly approximated by using intelligent estimation technique. Then, the “explosion of complexity” problem existing in the traditional backstepping procedure is solved by cleverly applying the command filtered backstepping method. In addition, an event-triggered mechanism is adopted so that the control input is updated irregularly following the occurrence of an event. The advantages of the proposed adaptive design scheme are as follows: (i) the Barbalat’s Lemma is used to asymptotically drive the tracking error to zero; (ii) all the variables in the closed-loop system are bounded; (iii) the utilized event-triggered mechanism reduces the transmission frequency of computer and saves computer resources. Finally, the simulation results of the robotic system are given to illustrate the effectiveness of our design scheme.
Immunoglobulin-G Enzyme-Linked Immunosorbent Assay Predicts Neutralising Antibody Response in Convalescent SARS-CoV-2 Patients
Authors: Kay Grant A , Owen Sophie I , Giorgi Emanuele , Williams Christopher T , Menzies Stefanie , Clark David J , Cuevas Luis , Davies Benedict M O , Eckersley Nicholas M , Hughes Grant L , Kirwan Daniela E , Krishna Sanjeev , Patterson Edward I , Planche Tim , Staines Henry M , Adams Emily R 
Published: April 2021

Abstract
Severe acute respiratory coronavirus 2 (SARS-CoV-2) has spread globally since its emergence in 2019. Most SARS-CoV-2 infections generate immune responses leading to rising levels of immunoglobulins (Ig) M, A and G which can be detected using diagnostic tests including enzyme-linked immunosorbent assays (ELISA). Whilst implying previous SARS-CoV-2 infection, the detection of Ig by ELISA does not guarantee the presence of neutralising antibodies (NAb) that can prevent the virus infecting cells. Plaque reduction neutralisation tests (PRNT) detect NAb but are not amenable to mass testing as they take several days and require use of viable SARS-CoV-2 in high biocontainment laboratories. We evaluated the ability of IgG and IgM ELISAs targeting SARS-CoV-2 spike subunit 1 (S1) and nucleocapsid protein (NP) at predicting the presence and magnitude of NAb determined by PRNT. SARS-CoV-2 IgG ELISA correlated well with NAb and was highly sensitive (93.8% [95% CI 79.2–99.2]) and specific (88.9% [95% CI 51.8–99.7%]) at predicting the presence of NAb. There was not a strong correlation between IgM ELISA and PRNT result. IgG ELISA provides a useful, high throughput method of predicting the presence of neutralising antibodies, with higher ELISA results increasing the likelihood of having a greater NAb titre.
Impactful Study of F-shaped Tunnel FET
Authors: SINGH PRABHAT , YADAV DHARMENDRA SINGH 
Published: April 2021

Abstract
In this proposed work, a novel single gate F-shaped channel tunnel field effect transistor (SG-FC-TFET) is proposed and investigated. The impact of thickness of the source region and lateral tunneling length between the gate oxide and edge of the source region on analog and radio frequency parameters are investigated with appropriate source and drain lateral length through the 2D-TCAD tool. The slender shape of the source enhanced the electric le crowding effect at the corners of the source region which reflect in term of high On-current (Ion). The Ion of proposed device is increased up to 10-4 A=μm with reduced sub-threshold swing (SS) is 7.3 mV/decade and minimum turn-ON voltage (Von = 0.28 V). The analog/RF parameters of SG-FC-TFET are optimized.
Future tense can reduce present bias in infrastructure design
Authors: Hancock Patrick , Klotz Leidy , Shealy Tripp , Johnson Eric , Weber Elke , Stenger Katelyn , Vuppuluri Richa 
Published: April 2021

Abstract
Design professionals (N = 261) were randomly assigned to either a future or present-framed project description before recommending design attributes for an infrastructure project. The future condition led designers to propose a significantly longer infrastructure design life, useful life to the community, and acceptable return on financial investment. The findings suggest that using future framing when soliciting sustainable design expertise can be a straightforward and inexpensive way to lessen present bias.