bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
Authors: Al-Mouqdad Mountasser M. , Huseynova Roya , Khalil Thanaa M. , Asfour Yasmeen S. , Asfour Suzan S. 
Published: June 2021

AbstractIntraventricular hemorrhage (IVH) and acute kidney injury (AKI) are important neonatal morbidities in premature infants. This study aimed to investigate the relationship between IVH and AKI in premature infants and whether this association affects the incidence of neonatal mortality. Infants [gestational age (GA) ≤ 32 weeks; birth weight (BW) < 1500 g] were retrospectively evaluated in a large tertiary neonatal intensive care unit. Of 710 premature infants, 268 (37.7%) developed AKI. Infants with IVH were more likely to have AKI than those without IVH. Infants with severe IVH had a higher incidence of AKI than infants with mild IVH. Infants younger than 28 weeks with IVH were more likely to have AKI than those without IVH. An association between IVH grades and AKI stages was observed in the overall study population, in infants with GA < 28 weeks, and in infants with GA between 28 and 32 weeks. Mortality was increased 1.5 times in infants with IVH and AKI compared with that in infants with IVH but without AKI. Furthermore, mortality was increased in infants with IVH and AKI compared with infants without IVH or AKI. This study shows a direct relationship between the severity of IVH and the degree of AKI; both IVH and AKI increase the incidence of neonatal mortality.
Wave-controlled aliasing in parallel imaging magnetization-prepared gradient echo (wave-CAIPI MPRAGE) accelerates speed for pediatric brain MRI with comparable diagnostic performance
Authors: Yim Younghee , Chung Mi Sun , Kim Su Yeong , Lee Na Mi , Byun Jun Soo , Chae Soo Ahn 
Published: June 2021

AbstractWe aimed to compare accelerated post-contrast magnetization-prepared rapid gradient-echo (MPRAGE) using wave-controlled aliasing in parallel imaging (wave-CAIPI) with conventional MPRAGE as a reliable method to diagnose intracranial lesions in pediatric patients. A total of 23 consecutive pediatric patients who underwent post-contrast wave-CAIPI and conventional MPRAGE (scan time: 2 min 39 s vs. 5 min 46 s) were retrospectively evaluated. Two radiologists independently assessed each image for the presence of intracranial lesions. Quantitative [contrast-to-noise ratio (CNR), contrast rate (CR), and signal-to-noise ratio (SNR)] and qualitative parameters (overall image quality, gray-white matter differentiation, demarcation of basal ganglia and sulci, and motion artifacts) were also surveyed. Wave-CAIPI MPRAGE and conventional MPRAGE detected enhancing and non-enhancing intracranial lesions with 100% agreement. Although wave-CAIPI MPRAGE had a lower SNR (all p < 0.05) and overall image quality (overall analysis, p = 0.02) compared to conventional MPRAGE, other quantitative (CNR and CR) and qualitative parameters (gray-white differentiation, demarcation of basal ganglia and sulci, and motion artifacts) were comparable in the pooled analysis and between both observers (all p > 0.05). Wave-CAIPI MPRAGE was a reliable method for diagnosing intracranial lesions in pediatric patients as conventional MPRAGE at half the scan time.
Thermal imaging potential and limitations to predict healing of venous leg ulcers
Authors: Monshipouri Mahta , Aliahmad Behzad , Ogrin Rajna , Elder Kylie , Anderson Jacinta , Polus Barbara , Kumar Dinesh 
Published: June 2021

AbstractArea analysis of thermal images can detect delayed healing in diabetes foot ulcers, but not venous leg ulcers (VLU) assessed in the home environment. This study proposes using textural analysis of thermal images to predict the healing trajectory of venous leg ulcers assessed in home settings. Participants with VLU were followed over twelve weeks. Digital images, thermal images and planimetry of wound tracings of the ulcers of 60 older participants was recorded in their homes by nurses. Participants were labelled as healed or unhealed based on status of the wound at the 12th week follow up. The weekly change in textural features was computed and the first two principal components were obtained. 60 participants (aged 80.53 ± 11.94 years) with 72 wounds (mean area 21.32 ± 51.28cm2) were included in the study. The first PCA of the change in textural features in week 2 with respect to week 0 were statistically significant for differentiating between healed and unhealed cases. Textural analysis of thermal images is an effective method to predict in week 2 which venous leg ulcers will not heal by week 12 among older people whose wounds are being managed in their homes.
Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
Authors: Alhassen Sammy , Chen Siwei , Alhassen Lamees , Phan Alvin , Khoudari Mohammad , De Silva Angele , Barhoosh Huda , Wang Zitong , Parrocha Chelsea , Shapiro Emily , Henrich Charity , Wang Zicheng , Mutesa Leon , Baldi Pierre , Abbott Geoffrey W. , Alachkar Amal 
Published: June 2021

AbstractIntergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational trauma transmission is a consequence of in-utero neurodevelopmental disruptions versus early-life mother–infant interaction is unknown. Here, we demonstrate that trauma exposure during pregnancy induces in mouse offspring social deficits and depressive-like behavior. Normal pups raised by traumatized mothers exhibited similar behavioral deficits to those induced in pups raised by their biological traumatized mothers. Good caregiving by normal mothers did not reverse prenatal trauma-induced behaviors, indicating a two-hit stress mechanism comprising both in-utero abnormalities and early-life poor parenting. The behavioral deficits were associated with profound changes in the brain metabotranscriptome. Striking increases in the mitochondrial hypoxia marker and epigenetic modifier 2-hydroxyglutaric acid in the brains of neonates and adults exposed prenatally to trauma indicated mitochondrial dysfunction and epigenetic mechanisms. Bioinformatic analyses revealed stress- and hypoxia-response metabolic pathways in the neonates, which produced long-lasting alterations in mitochondrial energy metabolism and epigenetic processes (DNA and chromatin modifications). Most strikingly, early pharmacological interventions with acetyl-L-carnitine (ALCAR) supplementation produced long-lasting protection against intergenerational trauma-induced depression.
Diversity-oriented synthesis of glycomimetics
Authors: Meanwell Michael , Fehr Gaelen , Ren Weiwu , Adluri Bharanishashank , Rose Victoria , Lehmann Johannes , Silverman Steven M. , Rowshanpour Rozhin , Adamson Christopher , Bergeron-Brlek Milan , Foy Hayden , Challa Venugopal Rao , Campeau Louis-Charles , Dudding Travis , Britton Robert 
Published: June 2021

AbstractGlycomimetics are structural mimics of naturally occurring carbohydrates and represent important therapeutic leads in several disease treatments. However, the structural and stereochemical complexity inherent to glycomimetics often challenges medicinal chemistry efforts and is incompatible with diversity-oriented synthesis approaches. Here, we describe a one-pot proline-catalyzed aldehyde α-functionalization/aldol reaction that produces an array of stereochemically well-defined glycomimetic building blocks containing fluoro, chloro, bromo, trifluoromethylthio and azodicarboxylate functional groups. Using density functional theory calculations, we demonstrate both steric and electrostatic interactions play key diastereodiscriminating roles in the dynamic kinetic resolution. The utility of this simple process for generating large and diverse libraries of glycomimetics is demonstrated in the rapid production of iminosugars, nucleoside analogues, carbasugars and carbohydrates from common intermediates.
Bridgman growth and characterization of a HoCa4O(BO3)3 crystal
Authors: He Xinchao , Sun Zhigang , Tu Xiaoniu , Wang Sheng , Xiong Kainan , Chen Hongbing , Zhang Xiaoyan , Shen Liming , Zheng Yanqing 
Published: June 2021

HoCa4O(BO3)3 grown with Bridgman method used in QPCPA system.
Cellular nucleic acid–binding protein is essential for type I interferon–mediated immunity to RNA virus infection
Authors: Chen Yongzhi , Lei Xuqiu , Jiang Zhaozhao , Fitzgerald Katherine A. 
Published: June 2021

Significance
Infections due to RNA viruses pose a substantial threat to human health around the globe. A better understanding of how the immune system controls RNA virus infection is critical for developing new treatments and vaccines. Here, we demonstrated that CNBP was required to control RNA virus infection through regulating the production of type I IFNs. Overall, we discovered an important role for CNBP in regulating innate immune responses and defined the underlying mechanisms, which suggest that CNBP might be a therapeutic target in controlling viral infections and inflammatory diseases.
Existence of radial solutions in the Chern–Simons–Higgs model with its

N=2

SUSY extension
Authors: Huang Hsin-Yuan , Kao Hsien-Chung 
Published: June 2021

Abstract
In this paper, we study a system of elliptic equations in

R

2

which arises from the abelian Chern–Simons–Higgs theory and its

N
=
2

SUSY extension. This system is expected to have three types of solutions: topological solutions, mixed type solutions and non-topological solutions. We establish the existence of the radial solutions of these three types.
Atomistic modelling of near-crack-tip plasticity
*
Authors: Buze Maciej 
Published: June 2021

Abstract
An atomistic model of near-crack-tip plasticity on a square lattice under anti-plane shear kinematics is formulated and studied. The model is based upon a new geometric and functional framework of a lattice manifold complex, which ensures that the crack surface is fully taken into account, while preserving the crucial notion of duality. As a result, existence of locally stable equilibrium configurations containing both a crack opening and dislocations is established. Notably, with the boundary in the form of a crack surface accounted for, no minimum separation between a dislocation core and the crack surface or the crack tip is required. The work presented here constitutes a foundation for several further studies aiming to put the phenomenon of near-crack-tip plasticity on a rigorous footing.
Retraction: Islamic diffusion in the countries of the Arctic region: the processes of Muslim migration to Scandinavian countries in the context of the transforming Islamic world (IOP Conf. Ser.: Earth Environ. Sci.
302 012070)
Authors: Kulik S V , Yu Eidemiller K , Biktimirova R R , Vanicheva M N 
Published: June 2021

IOP Publishing Limited ("IOPP") is retracting this paper following an investigation which resulted from a reader complaint. The paper makes a number of unsubstantiated claims and, in the opinion of IOPP, lacks scientific rigour, clarity and objectivity. Although the paper was subject to peer review via the conference organisers, unfortunately these issues were not identified on this occasion. IOPP also has concerns regarding the discriminatory tone and sentiment of the paper, which are not appropriate in a scientific journal.
IOPP expresses its thanks to the readers and independent advisors who have shared their thoughts regarding this paper during the course of the investigation.
Retraction published: 24 June 2021
Features of the organic-mineral intumescent paints structure formation for wooden constructions fire protection
Authors: Guzii S , Kurska T , Otrosh Y , Balduk P , Ivanov Y 
Published: June 2021

Abstract
The paper presents the results describing the features of the organic-mineral paints structure formation of the intumescent type for wooden structures fire protection. On the research basis a diagram of the coke formation process has been developed. It is shown that the introduction of titanium oxide and aluminum hydroxide in an amount of 5% promotes the ordering of the foam layer structure, an increase in its thermal stability and the achievement of the highest value of the swelling coefficient – up to 47, which is 1.7 times higher than the values of the swelling coefficient of the base composition. It was found that at 700 °C the formation of refractory compounds of the type TiP2O7, Mg3(PO4)2, AlPO4 occurs, which prevent the burnout of the formed coke foam and increase its strength and heat resistance. On the basis of the main provisions of fuzzy mathematics and data from physicochemical studies, a model of the mechanism of structure and coke formation and control of this process is proposed.
Change in effective viscosity and level of synergism of cement-containing mechanoactivated suspension
Authors: Ksonshkevych L , Barabash I , Streltsov K , Krantovska O 
Published: June 2021

Abstract
The article considers the influence of prescription factors (ground chamot, superplasticizer C-3) on the change of the effective viscosity of mechanically activated cement-containing suspensions used in the technology of lightweight concrete mixtures. The synergistic effect of reducing the viscosity of cement-containing suspensions during their activation in high-speed mixers of turbulent type in the presence of C-3 was revealed. Optimized modes of mechanical activation of suspensions that provide the maximum reduction of their effective viscosity.
Evaluation of the efficiency of using solar energy in the production of building composites
Authors: Plit A , Zavoloka M , Shynkevych O , Vinnichenko V 
Published: June 2021

Abstract
The results of research of speed of set of durability of fine-grained concrete are in-process presented on a compression which hardened in solar chamber of cyclic action. The analysis of existent types of industrial solar chambers is conducted and basic structural elements are considered. Resulted calculation of thermal balance of solar chambers. Experiments are conducted on compositions of fine-grained concrete on cement astringent with the use of additions of superplasticizers of firm MC - Bauchemie: MC - PowerFlow 3100 and MC - PowerFlow 2695. After self-control in solar chamber of cyclic action durability was determined determined at the different terms of hardening. The comparative analysis of results of durability is conducted on the compression of concrete in solar chamber and chamber of the normal hardening.
The James brand
Authors: Mizruchi Susan L. 
Published: June 2021

Abstract
‘The James brand’ examines how, during the period when he was introducing his brand to an Anglo-American public, Henry James honed his signature subject: plotting the fates of Americans abroad. If James was not the inventor of the international novel, he was certainly one of its most important proponents and developers. The first of James’s international novels, The American (1877), focuses on the mind of a woman; Portrait of a Lady (1881) reveals it to be an ideal register for the deep psychological transformations that became his trademark. James also wrote a major essay on literary criticism during this period, “The Art of Fiction” (1884).
Masterpieces
Authors: Mizruchi Susan L. 
Published: June 2021

Abstract
‘Masterpieces’ focuses on three of Henry James’s novels that are generally considered his greatest: The Ambassadors (1902), The Wings of the Dove (1903), and The Golden Bowl (1904). The Ambassadors is a meditation on the nature of ambition, destiny, and what makes a life meaningful. The Wings of the Dove deals with illness and suffering, and the moral conundrum presented by a dying girl possessed of great wealth she cannot enjoy, and her needy friends who seek to inherit it. The Golden Bowl is about the institutions of marriage and family, and how they are disrupted by passion. The chapter also examines James’s travel narrative, The American Scene (1907).
Public health
Authors: Slack Paul 
Published: June 2021

Abstract
‘Public health’ addresses plague policies and the notions of public health they embodied. The particular character of plague epidemics undoubtedly made its own contribution to the ways in which it was combated. It evidently came from outside, and its chief victims were the poor and disadvantaged—people with little political influence who seemed in need of control for other reasons. Surveillance and segregation followed naturally from that. Once begun, however, they appeared wherever rulers and regimes wanted to exercise greater control over their subjects. The reason why Europe was first in developing a particularly draconian code of public health seems likely to lie, therefore, in the realm of politics.
Total cost of care increases significantly from early to mild Alzheimer’s disease: 5-year ALSOVA follow-up
Authors: Jetsonen Viivi , Kuvaja-Köllner Virpi , Välimäki Tarja , Selander Tuomas , Martikainen Janne , Koivisto Anne M 
Published: June 2021

Abstract

Introduction
We studied the costs of formal and informal care in relation to Alzheimer’s disease (AD) progression.

Methods
231 persons with AD with a family caregiver were followed up for 5 years. The Clinical Dementia Rating Scale—Sum of Boxes (CDR-SB) was used to measure AD progression. Health and social care unit costs were used for formal care costs. An opportunity cost method for lost leisure time was applied to analyse the cost of informal care.

Results
Total cost of care in early stage AD (CDR-SB ≤ 4) was 16,448€ (95% CI 13,722–19,716) annually. In mild (CDR-SB 4.5–9), moderate (CDR-SB 9.5–15.5) and severe (CDR-SB ≥ 16) AD, the total costs were 2.3, 3.4 and 4.4 times higher, respectively. A one-unit increase in CDR-SB increased the total, formal and informal costs by 15, 11 and 18%, respectively.

Conclusions
Compared to early AD, the costs of total, formal and informal care are remarkably higher already in mild AD. This finding emphasises early diagnosis, interventions and family support for persons with AD and their caregivers.
SPP1 expression in the mouse uterus and placenta: implications for implantation†
Authors: Kramer Avery C , Erikson David W , McLendon Bryan A , Seo Heewon , Hayashi Kanako , Spencer Thomas E , Bazer Fuller W , Burghardt Robert C , Johnson Greg A 
Published: June 2021

Abstract
Secreted phosphoprotein 1 (SPP1, also known as osteopontin) binds integrins to mediate cell–cell and cell–extracellular matrix communication to promote cell adhesion, migration, and differentiation. Considerable evidence links SPP1 to pregnancy in several species. Current evidence suggests that SPP1 is involved in implantation and placentation in mice, but in vivo localization of SPP1 and in vivo mechanistic studies to substantiate these roles are incomplete and contradictory. We localized Spp1 mRNA and protein in the endometrium and placenta of mice throughout gestation, and utilized delayed implantation of mouse blastocysts to link SPP1 expression to the implantation chamber. Spp1 mRNA and protein localized to the endometrial luminal (LE), but not glandular epithelia (GE) in interimplantation regions of the uterus throughout gestation. Spp1 mRNA and protein also localized to uterine naturel killer (uNK) cells of the decidua. Within the implantation chamber, Spp1 mRNA localized only to intermittent LE cells, and to the inner cell mass. SPP1 protein localized to intermittent trophoblast cells, and to the parietal endoderm. These results suggest that SPP1: (1) is secreted by the LE at interimplantation sites for closure of the uterine lumen to form the implantation chamber; (2) is secreted by LE adjacent to the attaching trophoblast cells for attachment and invasion of the blastocyst; and (3) is not a component of histotroph secreted from the GE, but is secreted from uNK cells in the decidua to increase angiogenesis within the decidua to augment hemotrophic support of embryonic/fetal development of the conceptus.
Conferences in the time of COVID: notes on organizing and delivering the first Brain Conference
Authors: Li Lucia M , Bourke Niall J , Lai Helen H L , May Hazel G , Zimmerman Karl A , Bell Joanne , Riches Eleanor , Abu-Sway Safa , Sharp David J 
Published: June 2021

Abstract
To further fulfil their missions of promoting teaching, education and research in neurology and related clinical-academic disciplines, the Guarantors of Brain and the Brain journal family invited delegates to the first Brain Conference in Spring of this year. This event aimed to deliver excellent teaching and scientific presentations across a broad spectrum of neuroscience fields, with the key aim of making the content as accessible as possible. We hoped to capitalize on the benefits of an online format, whilst trying to capture a little of the joy of the in-person meeting. This article reports on the approach and practical choices made to achieve these goals, and we hope this will provide some guidance and advice to others organizing their own online conference.
Routinized Syphilis Screening Among Men Living With Human Immunodeficiency Virus: A Stepped Wedge Cluster Randomized Controlled Trial
Authors: Burchell Ann N , Tan Darrell H S , Grewal Ramandip , MacPherson Paul A , Walmsley Sharon , Rachlis Anita , Andany Nisha , Mishra Sharmistha , Gardner Sandra L , Raboud Janet , Fisman David , Cooper Curtis , Gough Kevin , Maxwell John , Rourke Sean B , Rousseau Rodney , Mazzulli Tony , Salit Irving E , Allen Vanessa G 
Published: June 2021

Abstract

Background
We implemented an opt-out clinic-based intervention pairing syphilis tests with routine human immunodeficiency virus (HIV) viral load testing. The primary objective was to determine the degree to which this intervention increased the detection of early syphilis.

Methods
The Enhanced Syphilis Screening Among HIV-Positive Men (ESSAHM) Trial was a stepped wedge cluster-randomized controlled trial involving 4 urban HIV clinics in Ontario, Canada, from 2015 to 2017. The population was HIV-positive adult males. The intervention was standing orders for syphilis serological testing with viral loads, and control was usual practice. We obtained test results via linkage with the centralized provincial laboratory and defined cases using a standardized clinical worksheet and medical record review. We employed a generalized linear mixed model with a logit link to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of the intervention.

Results
A total of 3895 men were followed over 7471 person-years. The mean number of syphilis tests increased from 0.53 to 2.02 tests per person per year. There were 217 new diagnoses of syphilis (control, 81; intervention, 136), for which 147 (68%) were cases of early syphilis (control, 61 [75%]; intervention, 86 [63%]). The annualized proportion with newly detected early syphilis increased from 0.009 to 0.032 with implementation of the intervention; the corresponding time-adjusted OR was 1.25 (95% CI, .71–2.20).

Conclusions
The implementation of standing orders for syphilis testing with HIV viral loads was feasible and increased testing, yet produced less-than-expected increases in case detection compared to past uncontrolled pre–post trials.

Clinical Trials Registration
NCT02019043.