bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural correlates of perceptual plasticity in the auditory midbrain and thalamus
Authors: Ying Rose , Stolzberg Daniel J. , Caras Melissa L. 
Published: January 2025

Hearing is an active process in which listeners must detect and identify sounds, segregate and discriminate stimulus features, and extract their behavioral relevance. Adaptive changes in sound detection can emerge rapidly, during sudden shifts in acoustic or environmental context, or more slowly as a result of practice. Although we know that context- and learning-dependent changes in the sensitivity of auditory cortical (ACX) neurons support many aspects of perceptual plasticity, the contribution of subcortical auditory regions to this process is less understood. Here, we recorded single- and multi-unit activity from the central nucleus of the inferior colliculus (ICC) and the ventral subdivision of the medial geniculate nucleus (MGV) of male and female Mongolian gerbils under two different behavioral contexts: as animals performed an amplitude modulation (AM) detection task and as they were passively exposed to AM sounds. Using a signal detection framework to estimate neurometric sensitivity, we found that neural thresholds in both regions improved during task performance, and this improvement was largely driven by changes in firing rate rather than phase locking. We also found that ICC and MGV neurometric thresholds improved as animals learn to detect small AM depths during a multi-day perceptual training paradigm. Finally, we reveal that in the MGV, but not the ICC, context-dependent enhancements in AM sensitivity grow stronger during perceptual training, mirroring prior observations in the ACX. Together, our results suggest that the auditory midbrain and thalamus contribute to changes in sound processing and perception over rapid and slow timescales.Significance statementWhat a listener hears depends on several factors, such as whether the listener is attentive or distracted, and whether the sound is meaningful or irrelevant. Practice can also shape hearing by improving the detection of particular sound features, as occurs during language or musical learning. Understanding how changes in sound perception arise in the brain is important for developing strategies to optimize healthy hearing, and for treating disorders in which these processes go awry. We report that neurons in the auditory midbrain and thalamus exhibit rapid shifts in sound sensitivity that depend on the sound’s behavioral relevance, and slower improvements that emerge over several days of training. Our results suggest that subcortical areas make an important contribution to flexible hearing.
“Interested by nobody but Mary Crawford”
Authors: Gilligan Christina J. 
Published: January 2025

Christina J. Gilligan, “‘Interested by nobody but Mary Crawford’: Identification and Critique in Mansfield Park” (pp. 157–181)
Critics often characterize Jane Austen’s Mansfield Park (1814) as a conservative outlier in her oeuvre. In this article, I argue that Mansfield Park represents a shift not in Austen’s ethico-political commitments but rather in the way she affectively structures the novel in relation to the protagonist. While in Sense and Sensibility and Pride and Prejudice, Austen aligns merit and attention in her identificatory heroines, in Mansfield Park, she affords heroic attention to Fanny Price while reserving heroic merit for Mary Crawford. Through this bold decoupling of attention from merit, Austen destabilizes the way meaning is communicated in her novels. No longer can readers rely on an only slightly qualified affective identification with the heroine to comprehend the novel’s project. Rather, readers must now engage for themselves in the kind of critical reading practices modeled by Mary and by Austen’s earlier heroines to grasp Mansfield Park’s critiques both of the Bertram family’s abuse of Fanny and of Fanny’s own limited ethical program. These critiques are bodied forth not through Fanny, who secures her marriage to Edmund through her own unethical reading failures, but instead through Mary, who shares the novel’s commitment to taking seriously the injustices of gender-based precarity and whose open-ended escape from Mansfield has been critically mischaracterized as a punishment for misbehavior.
Determinants of patient satisfaction after total knee arthroplasty (TKA): a literature review
Authors: Putera Anggi Dwi , Hasan Muhamad , Riyadli Muhammad , Fakhry Muhammad Nadlir 
Published: January 2025

Link of Video Abstract: https://youtu.be/VANVlW_pP94

Background: The most common form of degenerative joint disease is osteoarthritis. Concomitant with the increased prevalence of osteoarthritis, the incidence of total knee arthroplasty (TKA) also rises. Total knee arthroplasty (TKA) is a surgical procedure for replacing an abnormal knee joint with artificial materials. Total knee arthroplasty (TKA) is a cost-effective orthopedic surgery with good patient outcomes. This literature review aimed to elaborate on the determinants of patient satisfaction after TKA surgery.
Methods: This literature review was carried out by searching studies in three online databases consisting of Google Scholar, PubMed, and Wiley Online Library using the keywords “total knee arthroplasty”, “total knee replacement”, “osteoarthritis”, “satisfaction”, and “determinants” to specify our study results. Appropriate studies were then carried out through a narrative synthesis analysis.
Results: The satisfaction of patients after two broad components determines TKA. Internal and external. The internal component consists of the patient's age, gender, personality, expectations, comorbidity, the severity of the disease, and other factors such as BMI, economic and educational class. While the external component consists of anesthesia and pain management, surgery technique, implant or prosthesis type, post-operative rehabilitation and length of hospital stay. Therefore, the surgical technique, including its indications, alternatives, prospective results, and risk of issues, must be fully discussed between doctors and patients to maintain patient satisfaction following TKA.
Conclusion: The determinant of patient satisfaction following TKA surgery can be classified into internal components (patient-related factor) and external components (surgery-related factor). Although important, patient satisfaction shouldn't be the determining factor for evaluating the efficacy of surgical treatments and patient care.
Body mass index and total testosterone level in obese male pre-diabetic patients: correlation with homeostasis model assessment of insulin resistance
Authors: Decroli Eva , Aprilia Dinda , Kam Alexander , Rahmadi Afdol 
Published: January 2025

Link of Video Abstract: https://www.youtube.com/watch?v=zABLxwmAXtA

Introduction: Men with comorbidities are typically more likely to have testosterone insufficiency. In this study, total testosterone levels in obese male pre-diabetic patients will be correlated with body mass index and a homeostasis model assessment of insulin resistance (HOMA-IR).
Methods: This investigation is a cross-sectional analytical observational study. Insulin resistance was measured by HOMA-IR. Enzyme link immunosorbent assay (ELISA) was used to measure the total testosterone levels. 35 obese male patients who were also pre-diabetic had these signs evaluated.
Results: In this study, 35 obese male individuals with a family history of type 2 diabetes mellitus and an average age of 31.91 were included (3.79). The total testosterone level was 328.72 (94.94), the mean BMI was 33.12 (4.11) kg/m2, the HOMA-IR was 3.64 (1.00), and testosterone levels were lowered (300 ng/dl) in 48% of the individuals. In male pre-diabetic individuals, there was a strong negative connection between BMI and Total Testosterone levels (r = -0.567, p=0.001). In male pre-diabetic patients, there was a significant negative connection between HOMA-IR and total testosterone levels (r = -0.671, p=0.001).
Conclusion: In pre-diabetic obese male patients, there was a strong inverse relationship between total testosterone level and BMI. In obese male pre-diabetic individuals, there is a substantial negative association between HOMA-IR and total testosterone level.
The association between blood culture findings and increased procalcitonin levels in burn patients at the burn unit of RSUD Dr. Soetomo Surabaya
Authors: Zakanito Marelno , Saputro Iswinarno Doso , Zarasade Lobredia 
Published: January 2025

Link of Video Abstract: https://www.youtube.com/watch?v=ftHR9-tAQxs

Background: Normally, blood procalcitonin is generally undetectable in healthy individuals. However, blood procalcitonin levels can be detected in severe bacterial infections, especially sepsis. Blood culture is the gold standard for diagnosing sepsis; however, it takes 24-48 hours to obtain the results, making it difficult to administer antibiotics early.
Method: This is a cross-sectional observational retrospective analytic study. A total sampling method was used, where all burn patients who were treated at the Burns Unit at RSUD Dr. Soetomo Surabaya from 2020 to 2022 and met the inclusion criteria were enrolled if the data was complete. All burn patients treated at the Burn Unit of Dr. Soetomo Surabaya Hospital who underwent examination of blood procalcitonin levels and blood culture were included. Data collection was carried out by recording medical records. The data obtained from the research was entered into a table and then processed with SPSS 26 for Windows.
Result: There are a total of 84 patients, predominantly male (n=63; 75%). There were 79 patients with burns of more than 10% (94%). Out of 84 patients, 46 (54.8%) had bacteria or fungi in their blood culture, and 34 patients (40.5%) showed an increase in blood procalcitonin with levels of more than 2 ng/ml. There is an association between the presence of bacteria or fungi in blood culture and increased procalcitonin levels in the blood (p-value <0.05)
Conclusion: The most common bacteria found in blood cultures of burn patients in this study was gram-negative bacteria Acinetobacter baumannii. There is a significant relationship between the discovery of bacteria or fungi in blood culture and increasing blood levels of procalcitonin.
The profiles of mandibular fracture patients in the emergency ward of the head and neck surgery division in Dr. Soetomo General Hospital Indonesia
Authors: Rusdiansaputra Ferry , Wibowo Marjono Dwi 
Published: January 2025

Link of Video Abstract: https://youtu.be/dT_k0C9UhI0

Background: Maxillofacial fracture is one of the most common injuries in trauma patients, especially in patients with traffic accident mechanisms. In this study, we aim to analyze the profile of patients with maxillofacial fractures, especially mandibular fractures, who came to tertiary hospitals.
Methods: Observational descriptive study to evaluate the profile of mandibular fracture patients who came to the Emergency Department of the Head and Neck Surgery Division of Dr. Soetomo General Hospital Surabaya in 2022. Data were analyzed using SPSS version 23.0 for Windows.
Results: Subjects were grouped according to age, sex, and mechanism of trauma. The most prevalent gender was male. The age group with the highest prevalence of accidents was 11-20 years (32.5%). Most maxillofacial traumas were caused by traffic accidents (92.5%). Associated trauma was found in 65% of subjects. Mandibular fractures tend to occur as part of multiple maxillofacial fractures compared to a single maxillofacial fracture, which is as much as 65%. The most common location of the fracture line in the mandible is the mandibular parasymphysis, which accounted for 33.3% of all samples. The most common mandibular fracture lines were 2 lines (47.5%).
Conclusion: Mandibular fractures are more likely to be part of multiple maxillofacial fractures than a single maxillofacial fracture and are often accompanied by concomitant trauma to other organs than a single trauma.
Multiple re-exploration due to excessive bleeding due to coagulopathy after aortic valve replacement in patients with chronic asymptomatic hepatitis B infection: A case report
Authors: Napitupulu Rindu Anggara Parulian , Soenarto Ratna Farida , Heriwardito Aldy 
Published: January 2025

Link Of Video Abstract: https://youtu.be/RelpPxOynWw

Background: Postoperative bleeding following cardiac surgery represents a recognized and significant complication, particularly in patients with asymptomatic hepatitis B infection who have undergone open-heart procedures with a cardiopulmonary bypass machine (CPB). Patients requiring re-exploration due to bleeding face elevated mortality risks due to detrimental factors associated with the procedure, such as bleeding, transfusions, hypoperfusion resulting from cardiac tamponade or blood loss, multiple organ ischemia, and organ failure. The aim of this article is to discuss perioperative preparations specific to cases of patients with chronic hepatitis B undergoing open-heart surgery.
Case Presentation: This case study revolves around a 53-year-old Asian male who had been slated for aortic valve replacement. Transthoracic echocardiography (TTE) uncovered severe aortic regurgitation with vegetation at the non-coronary cusp (NCC) and right coronary cusp (RCC), accompanied by chamber dilatation. The patient was under Tenofovir therapy for his chronic yet asymptomatic hepatitis B infection. The surgical procedure utilized a cardiopulmonary bypass machine (CPB), but multiple re-explorations were necessitated due to excessive bleeding attributed to post-surgery coagulopathy.
Conclusion: Postoperative bleeding following cardiac surgery represents a widely recognized and serious complication, particularly in patients with asymptomatic hepatitis B infection who have undergone open-heart procedures with CPB. CPB has been extensively documented to stimulate the generation and release of various vasoactive substances and cytotoxic mediators, disrupting "rebalanced hemostasis" and leading to coagulopathy.
Interleukin-17 expression is associated with survival in pediatric osteosarcoma
Authors: Riza Muhammad , Salimo Harsono , Wasita Brian , Widyaningsih Vitri , Purwanto Bambang , Utomo Pamudji , Soestrisno Soestrisno , Hakim Fikar Arsyad , Zahidah Fairuz , Wayanshakty Janur 
Published: January 2025

Link of Video Abstract: https://youtu.be/qXGE9z-UpDs

Background: Osteosarcoma is a cancerous tumor that develops from bone-forming mesenchymal cells. The cause of osteosarcoma appears to be multifaceted, and cytokine production is a potential causative factor. T helper 17 cells are responsible for producing the cytokine interleukin 17 (IL-17), and its association with cancer progression remains a subject of ongoing debate. This study aimed to analyze IL-17 expression before and after neoadjuvant chemotherapy and the relationships between prognostic factors and survival.
Methods: We investigated the expression of IL-17 in osteosarcoma tissues from 22 pediatric patients who underwent neoadjuvant chemotherapy. Histopathological and immunohistochemical methods were used to assess IL-17 expression prior to the patients undergoing neoadjuvant chemotherapy. IL-17 expression before chemotherapy was classified as low or high based on the median data. Survival was calculated using the Kaplan–Meier survival analysis with the log-rank test.
Result: The following characteristics were found to be associated with longer survival: male, age > 10 years old, distal location of tumor, low-grade tumor, and tumor with no metastasis; however, there were no statistically significant differences (p > 0.05). Binary logistic analysis showed that high expression of IL-17 based on the median data before neoadjuvant chemotherapy (>1.62%) were significantly associated with reduced survival (p = 0.010). The mean estimated overall duration of survival was 19.4 months (95% confidence interval (CI): 14.5-24.3) for low IL-17 expression and 14.0 months (95%CI: 8.3–19.7) for high IL-17 expression based on the median data. There was no statistically significant difference in the overall survival (p > 0.05).
Conclusion: High expression of IL-17 before neoadjuvant chemotherapy after neoadjuvant chemotherapy were associated with poor survival among pediatric osteosarcoma patients. These findings suggest that IL-17 is a potential prognostic biomarker for pediatric osteosarcoma.
One health approach for taeniasis/cysticercosis control measure in Bali, Indonesia: updated situations, implementations, and challenges
Authors: Sudewi Anak Agung Raka , Swastika Kadek , Sudarmaja I Made , Wulanyani Ni Made Swasti , Dharmawan Nyoman Sadra , Wirawan I Made Ady , Kumbara Anak Agung Ngurah Anom , Pramitasuri Tjokorda Istri , Karang Anak Agung Ayu Suryapraba Indradewi , Ni Made Susilawathi  
Published: January 2025

Link of Video Abstract: https://youtu.be/RXotvX4x_ZM

Background: Taeniasis/cysticercosis (TC/CC), a group of infectious diseases caused by Taenia solium, is still a burden in Bali, particularly in the Kubu subdistrict. By utilizing Dukuh village as the representative location of TC/CC in the Kubu subdistrict as the continuation of earlier epidemiology studies in the same area, this study provides current situations and state-of-the-art risk factors of TC/CC along with an assessment of post-interventional indicators and their potential challenges in terms of One Health-based TC/CC control in Bali.
Methods: Community-based epidemiological surveys were conducted in the Kubu subdistrict in 2020 as a continuity of previous surveys held in 2011, 2013, 2014, 2015, 2016, and 2019, which have been published.
Results: In absolute counts, 14 out of 474 people were more seropositive than in 2019. Pig seroprevalence in Kubu was 2.92% (8/274) during the 2020 survey. A few related risk variables were investigated. Community-based interventions effectively elevated knowledge and behavior towards TC/CC in the Dukuh village society.
Conclusion: This study has significantly increased public knowledge, behavior, and awareness towards TC/CC as an early step in controlling the disease through the designated One Health framework. Despite some challenges in each stage of implementation, the One Health approach to TC/CC control measures in Bali is a worthwhile contribution to be made.
Open hernia repair and risk factors of recurrence at hospitals in Aceh, Indonesia
Authors: Sayuti Muhammad , Akbar Muhammad Khalilul , Simanjuntak Ami Dhania Rovi , Aprilita Rani 
Published: January 2025

Link of Video Abstract: https://youtu.be/T7_kPOIgTjo

Background: Hernia is a condition involving bulging a whole or part of an organ due to defect on the abdominal wall. Inguinal hernia is one of the most common types of abdominal wall hernia. There are approximately 20 million cases of hernia repair surgery done annually. Hernia repair is deemed successful if there is no recurrence and complications at a relatively affordable cost, and patients can return to daily routine immediately. The incidence of recurrence is affected by many factors, such as, the knowledge and skills of surgeons, surgical procedures and type of mesh used, mesh fixation techniques, management of lateral and medial hernia sacs, sliding hernia, lipoma in inguinal canal, surgery time, type of anesthesia, post-surgery complications, and factors coming from patients. This study was done to assess the prevalence of inguinal hernia and its recurrence, surgical procedures, and the risk factors related to the recurrence.
Methods: This cohort retrospective study used a total sampling technique in inguinal hernia patients who had received surgery.
Result: There were a total of 1457 patients from 2018 – 2022 from 10 public and private hospitals in North Aceh Regency and Lhokseumawe city. The study found that most hernia patients were male under 60 years of age. The highest risk factors of inguinal hernia were seen in patients with history of vigorous physical activity, chronic cough, and constipation.
Conclusion: Open hernia repair with mesh graft was the most used surgical procedure and most inguinal hernia patients did not have recurrence.
Surgical approach in lumbar spine tuberculosis, which is best? A meta-analysis
Authors: Rahardjo Irsa , Martiana I Ketut , Utomo Budi 
Published: January 2025

Link of Video Abstract: https://youtu.be/ZORIuJI9O2I

Introduction: Lumbar spine is the area with the maximum spinal load, great shearing force and the stress concentration points with high range of motion. Proper surgical approach in lumbar spinal TB will not only affect the biomechanical outcome but also the surgical outcome. Therefore, this study aims to analyze which of the two most commonly used approach, posterior or combined approach, is best for lumbar spinal TB
Methods: Studies comparing surgical approach of lumbar or lumbosacral spinal tuberculosis by single posterior approach versus combined anterior and posterior approach were identified in a literature search conducted from study inception to February 2023. Visual analog score (VAS), Cobb angle, Lordotic angle, Japanese Orthopedic Association (JOA) score, Erithrocyte Sedimentation Rate (ESR), surgical time, intraoperative bleeding, complication, and time of bone graft fusion was analyzed.
Results: In total, 855 studies were found from the search engines. From screening, 10 studies were finally included for the final quantitative analysis. No difference in VAS (p=0.87) and cobb angle difference (p=0.65) were found from the two studies. Better outcome for combined approach was found in terms of ESR decreasing (p=0.02), and time of bone graft fusion (p=0.09). Meanwhile, better outcome for posterior approach was found on lordotic angle (p=0.02), surgical time (p<0.05), intraoperative bleeding (p<0.05), and complication rate.
Conclusion: This meta-analysis found that posterior approach on one or two level of lumbar spinal TB enables better lordotic correction angle, surgical time, intraoperative bleeding, and complication incidence compared to combined approach.
Entrepreneurial skill level and self-perception of international young family doctors: Before and after basic entrepreneurship training
Authors: Erfen Gustiawan Suwangto  
Published: January 2025

Link of Video Abstract: https://youtu.be/xQBeStPkY6g

Background: Medical doctors lack entrepreneurship training. Thus, we held training that stimulates international young family doctors (in residency training or under 5 years after residency training) based on modification of standardized modules by International Labor Organization (ILO) in late 2019 until late 2020. This study aimed to measure the character readiness of young family doctors in entrepreneurship, review entrepreneurial traits and tendencies, competency clusters are identified, and get input in this training program.
Methods: This research was qualitative research using a descriptive and cross-sectional approach with voluntary sampling involving 32 young family doctors (members of the Asia Pacific World Organization) from end of 2019 to the end of 2020. We tested entrepreneurial skill level and self-perception before and after training. Data collection used structured and semi-structured questionnaires containing close-ended questions. Further data was analyzed to test significance using t test, paired sample test, and K-means to classify.
Results: Most trainees don’t know about self-serving disclosure, financial relations, and marketing budget in the medical business. There was a significant difference in the pre-test and post-test scores and we got 2 cluster groups with different values regarding entrepreneurial skills and self-perceptions among participants.
Conclusion: self-perception of young family doctors is not ready to become entrepreneurs, so further understanding of entrepreneurial content is needed. There are eight competencies built in this entrepreneurial training. Two competency clusters based on skill level were obtained.