bluuebunny/crossref_metadata_2025_split huggingface dataset:
TUBB3 E410K Syndrome With Childhood-Onset Nonalcoholic Steatohepatitis
Authors: Mori Jun , Umemura Atsushi , Satake Wataru , Cha Pei-Chieng , Suzuki Yutaka , Itoh Kyoko , Chiyonobu Tomohiro 
Published: August 2021

Abstract

Context
Nonalcoholic fatty liver disease (NAFLD) is becoming a major issue worldwide, even in children. Multiple parallel hits hypothesis has been suggested as progress of NAFLD, but the mechanism of NAFLD is not completely understood. β-Tubulin is essential in mitoses, neuronal migration, and axon guidance during neuronal development. Pathogenic variants in the TUBB3 gene were shown to be associated with a wide spectrum of neurological abnormalities, but not accompanied by hepatic complications, such as NAFLD.

Objective
This work aims to examine the association between TUBB3 mutation and nonalcoholic steatohepatitis (NASH).

Methods
An 11-year-old girl has been followed up as having atypical Möbius syndrome since infancy, as she was born with bilateral ptosis, paralytic strabismus, and facial weakness. At age 7 years, she was diagnosed with TUBB3 E410K syndrome by whole-exome sequencing. At age 10 years, her blood examination revealed elevated liver transaminase levels, which persisted for almost 2 years. She underwent liver biopsy, the results of which were suggestive of NASH.

Results
The expression of TUBB3 was absent, but that of tyrosine hydroxylase (TH) was present in the parenchymal nerve fibers of the liver. On the other hand, in comparison with an autopsy case of NASH and a normal control, these showed coexpression of TUBB3 and TH in the liver.

Conclusion
We report the first case of TUBB3 E410K syndrome accompanied by NASH. This case suggests that the TUBB3 mutation may be associated with the pathogenesis and progression of NASH in humans.
Implementation of Intraoperative Ultrasound Localization for Breast-Conserving Surgery in a Large, Integrated Health Care System is Feasible and Effective
Authors: Chakedis Jeffery M. , Tang Annie , Kuehner Gillian E. , Vuong Brooke , Lyon Liisa L. , Romero Lucinda A. , Raber Benjamin M. , Mortenson Melinda M. , Shim Veronica C. , Datrice-Hill Nicole M. , McEvoy Jennifer R. , Arasu Vignesh A. , Wisner Dorota J. , Chang Sharon B. ,   The Permanente Medical Group Breast Research Collaborative
Published: August 2021

Abstract
Background
Intraoperative ultrasound (IUS) localization for breast cancer is a noninvasive localization technique. In 2015, an IUS program for breast-conserving surgery (BCS) was initiated in a large, integrated health care system. This study evaluated the clinical results of IUS implementation.

Methods
The study identified breast cancer patients with BCS from 1 January to 31 October 2015 and from 1 January to 31 October 2019. Clinicopathologic characteristics were collected, and localization types were categorized. Clinical outcomes were analyzed, including localization use, surgeon adoption of IUS, day-of-surgery intervals, and re-excision rates. Multivariate logistic regression analysis was performed to evaluate predictors of re-excision.

Results
The number of BCS procedures increased 23%, from 1815 procedures in 2015 to 2226 procedures in 2019. The IUS rate increased from 4% of lumpectomies (n = 79) in 2015 to 28% of lumpectomies (n = 632) in 2019 (p < 0.001). Surgeons using IUS increased from 6% (5 of 88 surgeons) in 2015 to 70% (42 of 60 surgeons) in 2019. In 2019, 76% of IUS surgeons performed at least 25% of lumpectomies with IUS. The mean time from admission to incision was shorter with IUS or seed localization than with wire localization (202 min with IUS, 201 with seed localization, 262 with wire localization in 2019; p < 0.001). The IUS re-excision rates were lower than for other localization techniques (13.6%, vs 19.6% for seed localization and 24.7% for wire localization in 2019; p = 0.006), and IUS predicted lower re-excision rates in a multivariable model (odds ratio [OR], 0.59).

Conclusions
In a high-volume integrated health system, IUS was adopted for BCS by a majority of surgeons. The use of IUS decreased the time from admission to incision compared with wire localization, and decreased re-excision rates compared with other localization techniques.
Factors influencing COVID-19 vaccine acceptance in Indonesia: an adoption of Technology Acceptance Model
Authors: Faturohman Taufik , Kengsiswoyo Giofella Adesta Navaky , Harapan Harapan , Zailani Suhaiza , Rahadi R. Aswin , Arief Neneng Nurlaela 
Published: August 2021

Background: It is critical to understand the factors that could affect the acceptance of the coronavirus disease 2019 (COVID-19) vaccine in the community. The aim of this study was to determine factors that could possibly affect the acceptance of Indonesian citizens of COVID-19 vaccination using a Technology Acceptance Model (TAM), a model how users come to accept and use a technology. Methods: An online survey was conducted between the first and fifth of November, 2020. Participants were asked to respond to questions on acceptance, perceived usefulness, perceived ease of use, perceived religiosity towards, and amount of information about COVID-19. This study used the Technology Acceptance Model (TAM) as the framework to decide factors that affect vaccine acceptance. Structural Equation Model was employed to assess the correlation between all explanatory variables and vaccine acceptance. Mann-Whitney test and Kruskal-Wallis rank were employed to assess demographic factors associated with acceptance. Results: In total, 311 responses were included for analysis. Our TAM model suggested that high perceived usefulness significantly increased COVID-19 vaccine acceptance and high perceived ease of use significantly increased the perceived usefulness. Perceived religiosity did not substantially affect vaccine acceptance. The amount of information on COVID-19 also did not significantly affect vaccine acceptance. Our data suggested that vaccine acceptance was associated with age, type of occupation, marital status and monthly income to some degree. Conclusion: Since perceived usefulness affects vaccine acceptance, the government should focus on the usefulness of the vaccine when promoting the COVID-19 vaccine to Indonesian citizens. In addition, since perceived ease of use significantly affects users’ acceptance to COVID-19 vaccine, the easier to acquire the vaccine in the community, the higher chance that the citizens are willing to be vaccinated.
Taxonomic studies and three new records on genus Geostachys (Baker) Ridl. in Thailand
Authors: Saensouk Piyaporn , Saensouk Surapon 
Published: August 2021

Abstract. Saensouk P, Saensouk S. 2021. Taxonomic studies and three new records on genus Geostachys (Baker) Ridl. in Thailand. Biodiversitas 22: 3057-3067. A comprehensive taxonomic study and three new records of genus Geostachys (Baker) Ridl. in Thailand have not been reported. This research aimed to study the taxonomical aspect of the genus Geostachys in Thailand based on herbarium collections, fresh materials, and available literatures. Nine species of Geostachys have been recognized with their updated nomenclature in Thailand, namely G. angustifolia K. Larsen, G. chayanii Mayoe, G. decurvata (Baker) Ridl., G. holttumii K. Larsen, G. kerrii K. Larsen, G. penangensis Ridl., G. pierreana Gagnep., G. smitinandii K. Larsen, and. G. tratensis Picheans. & Mayoe. Three species, namely G. decurvata, G. pierreana, and G. penangensis are found to be new records to Thailand. Six species, namely G. angustifolia, G. chayanii, G. holttumii, G. kerrii, G. smitinandii, and G. tratensis were endemic to Thailand. The identification key to species, detailed descriptions, photographs, vernacular name, geographical distribution, ecology, phenology, conservation status, and taxonomic notes have been provided.
Abundance, diversity and daily activity of terrestrial mammal and bird species in disturbed and undisturbed limestone habitats using camera trapping, Central Thailand
Authors: PLA-ARD MANANYA , HOONHEANG WIPAVEE , KAEWDEE BUNYATHIPORN , PANGANTA TARAPON , CHARASPET KHWANRUTAI , KHOIESRI NORASET , PAANSRI PAANWARIS , KANKA PEMIKA , CHANACHAI YUWARAK , THONGBANTHUM JIDAPHA , BANGTHONG PHANITSUPHA , Sukmasuang Ronglarp 
Published: August 2021

Abstract: Pla-ard M, Hoonheang W, Kaewdee B, Panganta T, Charaspet K, Khoiesri N, Paansri P, Kanka P, Chanachai Y, Thongbanthum J, Bangthong P, Sukmasuang R. 2021. Abundance, diversity and daily activity of terrestrial mammal and bird species in disturbed and undisturbed limestone habitats using camera trapping, Central Thailand. Biodiversitas 22: 3620-3631. This study on the abundance, diversity and daily activity of terrestrial mammal and bird species was conducted in the limestone mountainous area of Central Thailand, located on the east of Dong Phaya Yen-Khao Yai forest complex. Camera traps were placed in both habitats disturbed by limestone mining and undisturbed habitat areas. From the study, a total of 38 species of mammals and birds from 27 families in 13 orders were recorded, including 15 species of mammals from 6 orders, 12 families and 23 species of birds from 14 families in 7 orders. Fifteen species of mammals were recorded in the undisturbed area and 11 were recorded in the disturbed area, with the Malayan Pangolin, Small Indian Civet and Grey-bellied Squirrel found in the undisturbed area. However, the number of bird species in the limestone mining area was larger than in the undisturbed area. It was also found that there was no difference in the overall abundance and diversity of mammalian species between disturbed and undisturbed areas, which is not in accordance with the hypothesis. But in the case of wild birds, the relative abundance of wild birds was found to differ significantly between areas. A high number was found in the areas with mining activities, although there was no difference in the diversity index of the two areas. However, it was found that when the combined data was analyzed, there was a significant difference in the daily activity of both mammals and wild birds in both areas. Many rare wildlife species were recorded during this study, for example, the Malayan Pangolin, Serow, Northern Pig-tailed Macaque, Rufous Limestone-babbler, Golden Jackal, Leopard Cat, Large-toothed Ferret Badger, Small Asian Mongoose, Common Palm Civet, Small Indian Civet, Malayan Porcupine. The key measure proposed is to preserve some natural habitats within the areas with mining activities, as wildlife remains in the area.
Toxic adenoma: to biopsy or not to biopsy?
Authors: Goonoo MS , Arshad MF , Tahir F , Balasubramanian SP 
Published: August 2021

Toxic adenoma nodules rarely harbour cancer. Fine-needle aspiration (FNA) is often not done because of the rarity of these lesions being cancer, the difficulty in interpreting cytology in hyperthyroid patients and the rare precipitation of thyrotoxicosis. We present two young, Caucasian female patients aged 29 and 13 years who were each diagnosed with a toxic nodule categorised as benign and indeterminate respectively. They underwent hemithyroidectomy after being rendered euthyroid, however their histology unexpectedly revealed differentiated follicular cancer. Despite thyroid cancer being rare in patients with toxic adenomas, it should be considered when planning treatment, especially if there are risk factors for cancer, or suspicious features on ultrasound examination. A review of the literature shows that compared with adenomas in euthyroid patients, patients in this group are generally younger and predominately female. If an FNA is considered, it should be performed after the patient is rendered euthyroid.
‘Mind if I record this?’ Patients making audio-visual recordings of consultations: a survey of surgeons’ experiences
Authors: Magowan D , Burton L , Williams GL , Khurana A 
Published: August 2021

Introduction Audio-visual recordings made by patients of their clinical encounters are increasingly common. This may be done with or without their doctors’ knowledge or consent and is considered admissible legal evidence. Many surgeons may feel uncomfortable with being recorded and lack knowledge regarding the legal implications. The aim of this study was to gauge how surgeons react to being recorded, and what specific medico-legal insight they have regarding these matters. Methods In total, 150 surveys were distributed to surgeons in two hospitals in South Wales by email, Survey Monkey and paper copy between 28 October 2019 and 9 March 2020. The survey was anonymous and recorded level of training, as well as four simple questions regarding how surgeons may react to being recorded and what they felt their legal rights were. Results There were 91 respondents: 28 consultants, 36 registrars and 27 junior surgical trainees. Of the respondents, 56% were uncomfortable with being recorded and 23% would stop a consultation if their patient insisted on recording it. These issues were most marked for junior surgical trainees. Sixty-two per cent of respondents were unaware of their legal rights and 21% believed they were legally able to refuse to continue a consultation. This belief was particularly marked among consultants. Conclusion Many surgeons are uncomfortable with being recorded and lack knowledge regarding their medico-legal standing. Education and guidance from the Royal Colleges would help address this issue and avoid misunderstanding when surgeons are faced with these potentially difficult scenarios.
Make America Hate Again: Trump-Era Horror and the Politics of Fear, Victoria McCollum (ed.) (2019)
Authors: Stilley Harriet 
Published: August 2021

Review of: Make America Hate Again: Trump-Era Horror and the Politics of Fear, Victoria McCollum (ed.) (2019)
New York: Routledge, 230 pp.,
ISBN 978-1-13849-828-0, h/bk, £120, ISBN 978-0-36772-745-1, p/bk, £36.99
Antagonismo de rizobacterias sobre hongos fitopatógenos, y su actividad microbiana con potencial biofertilizante, bioestimulante y biocontrolador
Authors: Blanco Carrero Erika Lorena , Castro Molina Yulimar 
Published: August 2021

Las rizobacterias forman parte de la gran cantidad de microorganismos que actúan como agentes de biocontrol, produciendo metabolitos que inducen resistencia sistémica en las plantas que inhiben el crecimiento de patógenos. El objetivo de esta investigación fue evaluar la capacidad de diez rizobacterias de los géneros Rhizobium, Bradyrhizobium, Sinorhizobium, Ochrobactrum y Pseudomonas para producir ácido cianhídrico (HCN), sideróforos y ácido indol-acético (AIA), disolver fosfato, fijar nitrógeno e inhibir el crecimiento de fitopatógenos. Se realizaron todas las pruebas fisiológicas y bioquímicas correspondientes, así como la prueba de antagonismo in vitro contra los fitopatógenos Fusarium oxysporum, Colletotrichum gloeosporioides y Rhizoctonia solani. Cinco cepas produjeron una mayor cantidad de AIA en relación a las otras en presencia de triptófano, la cepa ES1 (Ochrobactrum sp.) produjo HCN, el 50 % de las cepas evaluadas liberaron sideróforos, el 60 % disolvió fósforo, y todas resultaron positivas para la fijación de nitrógeno. Nueve cepas inhibieron el crecimiento de F. oxysporum entre 40 % y 65 %, la cepa Alf (Pseudomonas fluorescens) inhibió además el crecimiento de C. gloeosporioides en un 22 %, y ninguna inhibió el crecimiento de R. solani. Los rizobios evaluados y la cepa de Pseudomonas fluorescens podrían ejercer efectos beneficiosos sobre las plantas a través de mecanismos directos e indirectos, o una combinación de ambos, lo que las convierte en una opción sostenible para la producción de cultivos.
Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants: A replication study
Authors: van Oorsouw Kim I. , Uthaug Malin V. , Mason Natasha L. , Broers Nick J. , Ramaekers Johannes G. 
Published: August 2021

Abstract

Background and aims
There is a growing body of evidence suggesting that the psychedelic plant tea, ayahuasca, holds therapeutic potential. Uthaug et al. (2018) demonstrated that a single dose of ayahuasca improved mental health sub-acutely and 4-weeks post-ceremony in healthy participants. The present study aimed to replicate and extend these findings. A first objective was to assess the sub-acute and long-term effects of ayahuasca on mental health and well-being in first-time and experienced users. A second aim was to extend the assessment of altered states of consciousness and how they relate to changes in mental health.

Method
Ayahuasca ceremony attendants (N = 73) were assessed before, the day after, and four weeks following the ceremony.

Results
We replicated the reduction in self-reported stress 4-weeks post ceremony, but, in contrast, found no reduction in depression. Also, increased satisfaction with life and awareness the day after the ceremony, and its return to baseline 4 weeks later, were replicated. New findings were: reduced ratings of anxiety and somatization, and increased levels of non-judging 4-weeks post-ceremony. We replicated the relation between altered states of consciousness (e.g., experienced ego dissolution during the ceremony) and mental health outcomes sub-acutely. The effects of ayahuasca did not differ between experienced and first-time users.

Conclusion
Partly in line with previous findings, ayahuasca produces long-term improvements in affect in non-clinical users. Furthermore, sub-acute mental health ratings are related to the intensity of the psychedelic experience. Although findings replicate and highlight the therapeutic potential of ayahuasca, this needs to be confirmed in placebo-controlled studies.
Bribery and Control in Stable Marriage
Authors: Boehmer Niclas , Bredereck Robert , Heeger Klaus , Niedermeier Rolf 
Published: August 2021

We initiate the study of external manipulations in Stable Marriage by considering several manipulative actions as well as several manipulation goals. For instance, one goal is to make sure that a given pair of agents is matched in a stable solution, and this may be achieved by the manipulative action of reordering some agents' preference lists. We present a comprehensive study of the computational complexity of all problems arising in this way. We find several polynomial-time solvable cases as well as NP-hard ones. For the NP-hard cases, focusing on the natural parameter "budget" (that is, the number of manipulative actions one is allowed to perform), we also conduct a parameterized complexity analysis and encounter mostly parameterized hardness results.
Histologi, Histomorfometri, dan Histokimia Hati Ayam Buras (Gallus gallus domesticus) Selama Periode Sebelum dan Setelah Menetas
Authors: Siswandy Siswandy , Rahmi Erdiansyah , Masyitha Dian , Fitriani Fitriani , Gani Fadli A. , Zuhrawaty Zuhrawaty , Akmal Muslim 
Published: August 2021

ABSTRAK. Hati adalah kelenjar terbesar yang terdapat di dalam tubuh dan dapat dianggap sebagai organ pusat dalam pemeliharaan suplai energi. Penelitian ini bertujuan untuk mengetahui histologi, histomorfometri, dan histokimia sebaran glikogen pada hati ayam buras sebelum dan sesudah menetas. Sampel penelitian dibagi menjadi empat kelompok tingkat umur berbeda dan masing-masing kelompok berjumlah enam hati ayam. Hasil penelitian menunjukkan perbedaan nyata (P0,05) pertumbuhan hati ayam buras secara makroskopis. Pada setiap perkembangan sudah terdapat hepatosit berbentuk poligon yang memiliki inti sel bulat di tengah hepatosit, terdapat juga vena central yang dilapisi sel endotel pipih selapis serta didapati sinusoid yang berada diantara hepatosit, dan juga ditemukan Kupffer’s cell hanya pada hati ayam setelah menetas hari ke-7. Hasil pengukuran diameter vena central hati ayam buras hari ke-7, hari ke-14, hari ke- 20 sebelum menetas dan hari ke-7 setelah menetas berturut-turut adalah 17,70 ± 1,16 µm; 60,32 ± 2,22 µm; 49,316 ± 1,93 µm; dan 129,11 ± 7,43 µm. Hasil histokimia sebaran glikogen pada hati ayam buras hari ke-14, hari ke- 20 sebelum menetas dan hari ke-7 setelah menetas berturut-turut adalah 1,44 ± 0,93; 2,27 ± 0,74; dan 2,77 ± 0,15. Dapat disimpulkan, bahwa diameter vena central dan sebaran glikogen meningkat seiring pertumbuhan ayam buras. (Histological, histomorphometrical, and histochemical of liver on native chicken (Gallus gallus domesticus) during pre and posthatch period) ABSTRACT. The liver is the largest gland in the body and considered as a central organ in maintaining energy supplies. The study aimed to determine the histologic, histomorphometric and histochemical of glycogen distribution in the liver of native chicken during pre and posthatching period.. The study sample were divided into four different age groups and each group consisted of six chicken livers. The results showed a significant difference (P0,05) in native chicken liver growth macroscopically. In every development there are already polygonal hepatocytes that have a round cell nucleus in the middle of the hepatocytes, there is also a central vein that is coated with a layer of flat endothelial cells and also sinusoids that are between the hepatocytes, and kupffer's cells also found in chicken liver 7th day posthatching. The results measurements of the central vein diameter in liver native chickens on the 7th, 14th, 20th pre hatching period and 7th post hatching were 17.70 ± 1.16 µm; 60.32 ± 2.22 µm; 49.32 ± 1.93 µm; and 129.11 ± 7,43 µm; The measure results of the glycogen distribution in liver native chickens on the 14th, 20th pre hatching period and 7th post hatching were 1,44 ± 0,93; 2,27 ± 0,74; and 2,77 ± 0,15. It can be concluded, that central vein diameter and glycogen distribution were increased by growth of native chickens.
Histologis Perkembangan Embrio Ayam pada Masa Inkubasi Satu sampai Tujuh Hari
Authors: Fitriani Fitriani , Husmimi Husmimi , Masyitha Dian , Akmal Muslim 
Published: August 2021

ABSTRAK. Penelitian ini bertujuan melihat perkembangan embrio ayam secara histologi pada waktu 1, 2, 3, 4, 5, dan 7 hari inkubasi. Sampel yang digunakan adalah telur fertil yang didapat dari teaching farm Fakultas Pertanian Jurusan Peternakan Universitas Syiah Kuala. Pengamatan secara makroskopis dilakukan pada setiap sampel embrio ayam, sementara pengamatan mikroskopis struktur embrio ayam dilakukan dengan pembuatan preparat histologi. Hasil penelitian ini menampilkan data perkembangan embrio ayam secara spesifik dari umur inkubasi hari ke-1 sampai hari ke-7. Secara makroskopik dan mikroskopis, gambaran umum perkembangan embrio ayam selaras dengan informasi tabel pertumbuhan embrio ayam. Secara histologis, gambaran perkembangan struktur embrio ayam baru dapat diamati dengan baik yaitu pada umur inkubasi hari ke-3 sampai hari ke-7. Dapat disimpulkan bahwa secara histologi perkembangan embrio ayam baru dapat diamati pada masa inkubasi hari ke-3. Penelitian ini juga dapat dijadikan sebagai bahan acuan dasar untuk penelitian lanjutan terutama terhadap organogenesis pada embrio ayam. (Histological evaluation on the development of chicken embryo during the incubation periodfrom 1st to 7th days) ABSTRACT. The aim of this study was to find out the development of chicken embryos at day 1st, 2nd, 3rd, 4th, 5th, and 7th of incubation by histological method. The samples used were the fertile eggs obtained from the teaching farm of the Faculty of Agriculture, Department of Animal Husbandry, Syiah Kuala University. Macroscopic observations were made on each embryos sample, while microscopic observations of the embryos structure were carried out by histological preparations procedure. The results of this study presented the specific data of chicken embryos development from day 1st to day 7th of incubation. The macroscopic and microscopic data showed the general description of chicken embryos development similar to the information on the chicken embryo growth table. The microscopic results showed the structure description of the chicken embryos can be well observed at day 3rd to the day 7th of incubation. It can be seen the development of chicken embryos can be observed by histology method on day 3rd of incubation. This research can also be used as a basic reference for further research, especially on organogenesis of chicken embryos.