bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of environmental factors on plantings of wild-simulated American Ginseng
Authors: Sheban Karam C. , Woodbury David J. , Duguid Marlyse C. 
Published: November 2021

AbstractAmerican ginseng (Panax quinquefoliusL.) is an herbaceous perennial plant native to the forests of eastern North America with a long history of use and harvest, and with a significant international market. To supply international demand, the plant is grown in the USA and Canada under artificial shade cloth. However, wild and wild-appearing ginseng roots command prices up to 100 times greater than roots cultivated in a field: $550–2200 (US$ dry kg) vs. $20–70 (US$ dry kg). Growing ginseng in a forested environment using a “wild-simulated” forest farming approach, where growers introduce ginseng into a forested environment and then let it grow with little to no intervention, allows forest farmers to access these higher prices and meet international demand. As climate change shifts growing conditions globally, there will be increasing opportunities for the forest farming of American ginseng internationally. In this study, we examined the main drivers of ginseng growth and development in a wild-simulated ginseng forest farm. We measured the range of environmental conditions and built statistical models to examine which factors were most important for ginseng vigor. We found that the amount of sunlight, even under highly shaded conditions, was the most important driver of ginseng establishment on the landscape, as well as ginseng plant size and development. Prior research indicates that additional factors including soil nutrient levels, moisture, and texture are important for the survival, growth, and development of wild and planted American ginseng, but our study did not show significant patterns of importance at this site. Our findings suggest that integrating silvicultural techniques such as forest thinning may enhance the productivity of wild-simulated ginseng operations while providing additional forest-based income with minimal impact on natural forest ecosystems.
A Scoping Review of Associations Between Cannabis Use and Anxiety in Adolescents and Young Adults
Authors: Stiles-Shields Colleen , Archer Joseph , Zhang Jim , Burnside Amanda , Draxler Janel , Potthoff Lauren M. , Reyes Karen M. , Summersett Williams Faith , Westrick Jennifer , Karnik Niranjan S. 
Published: November 2021

AbstractCannabis and anxiety are both rising issues that impact young people. This review seeks to explore the association between anxiety and cannabis in adolescents and young adults (AYA). A database search was run retrospectively from July 2020 through calendar year 2013. Articles had to present outcomes examining cannabis use and symptoms of anxiety, be written in English, contain samples with ≥ 50% who are age 25 or younger, and be published in a peer-reviewed journal. Forty-seven studies were identified that examined the relationship between anxiety and cannabis use. Twenty-three studies found a positive association that greater anxiety among AYA was associated with greater cannabis use. In contrast, seven studies found a negative association that greater anxiety was related to less cannabis use. And finally, 17 studies found no clear association between anxiety and cannabis use. Further research is needed to better understand the relationship between anxiety and cannabis use.
Development of a multiplex microsatellite marker set for the study of the solitary red mason bee, Osmia bicornis (Megachilidae)
Authors: Van Eeckhoven Jens , Horsburgh Gavin J. , Dawson Deborah A. , Mayer Kathryn , Bretman Amanda , Duncan Elizabeth J. 
Published: November 2021

Abstract
Background
Solitary bees, such as the red mason bee (Osmia bicornis), provide important ecosystem services including pollination. In the face of global declines of pollinator abundance, such haplodiploid Hymenopterans have a compounded extinction risk due to the potential for limited genetic diversity. In order to assess the genetic diversity of Osmia bicornis populations, we developed microsatellite markers and characterised them in two populations.

Methods and results
Microsatellite sequences were mined from the recently published Osmia bicornis genome, which was assembled from DNA extracted from a single male bee originating from the United Kingdom. Sequences were identified that contained dinucleotide, trinucleotide, and tetranucleotide repeat regions. Seventeen polymorphic microsatellite markers were designed and tested, sixteen of which were developed into four multiplex PCR sets to facilitate cheap, fast and efficient genotyping and were characterised in unrelated females from Germany (n = 19) and England (n = 14).

Conclusions
The microsatellite markers are highly informative, with a combined exclusion probability of 0.997 (first parent), which will enable studies of genetic structure and diversity to inform conservation efforts in this bee.
A Battle in the Statistics Wars: a simulation-based comparison of Bayesian, Frequentist and Williamsonian methodologies
Authors: Radzvilas Mantas , Peden William , De Pretis Francesco 
Published: November 2021

AbstractThe debates between Bayesian, frequentist, and other methodologies of statistics have tended to focus on conceptual justifications, sociological arguments, or mathematical proofs of their long run properties. Both Bayesian statistics and frequentist (“classical”) statistics have strong cases on these grounds. In this article, we instead approach the debates in the “Statistics Wars” from a largely unexplored angle: simulations of different methodologies’ performance in the short to medium run. We used Big Data methods to conduct a large number of simulations using a straightforward decision problem based around tossing a coin with unknown bias and then placing bets. In this simulation, we programmed four players, inspired by Bayesian statistics, frequentist statistics, Jon Williamson’s version of Objective Bayesianism, and a player who simply extrapolates from observed frequencies to general frequencies. The last player served a benchmark function: any worthwhile statistical methodology should at least match the performance of simplistic induction. We focused on the performance of these methodologies in guiding the players towards good decisions. Unlike an earlier simulation study of this type, we found no systematic difference in performance between the Bayesian and frequentist players, provided the Bayesian used a flat prior and the frequentist used a low confidence level. The Williamsonian player was also able to perform well given a low confidence level. However, the frequentist and Williamsonian players performed poorly with high confidence levels, while the Bayesian was surprisingly harmed by biased priors. Our study indicates that all three methodologies should be taken seriously by philosophers and practitioners of statistics.
Imagining one experience to be another
Authors: Nanay Bence 
Published: November 2021

AbstractI can imagine a banana to be a phone receiver. I can also imagine the flapping of my arms to be flying. So it is possible to imagine one thing to be another—at least for some types of ‘things’. I will argue that although it is possible to imagine an object to be another object and it is also possible to imagine an activity to be a different activity, one cannot imagine one’s present sensory experience to be a different sensory experience with different qualitative character. This claim will have some important consequences beyond the philosophy of imagination, for example, for some accounts of depiction.
Generics: some (non) specifics
Authors: Bosse Anne 
Published: November 2021

AbstractThis paper is about an underappreciated aspect of generics: their non-specificity. Many uses of generics, utterances like ‘Seagulls swoop down to steal food’, express non-specific generalisations which do not specify their quantificational force or flavour. I consider whether this non-specificity arises as a by-product of context-sensitivity or semantic incompleteness but argue instead that generics semantically express non-specific generalisations by default as a result of quantifying existentially over more specific ones.
Causality and determination revisited
Authors: Ometto Dawa 
Published: November 2021

AbstractIt seems to be a platitude that there must be a close connection between causality and the laws of nature: the laws somehow cover in general what happens in each specific case of causation. But so-called singularists disagree, and it is often thought that the locus classicus for that kind of dissent is Anscombe's famous Causality & Determination. Moreover, it is often thought that Anscombe's rejection of determinism is premised on singularism. In this paper, I show that this is a mistake: Anscombe is not a singularist, but in fact only objects to a very specific, Humean understanding of the generality of laws of nature and their importance to causality. I argue that Anscombe provides us with the contours of a radically different understanding of the generality of the laws, which I suggest can be fruitfully developed in terms of recently popular dispositional accounts. And as I will show, it is this account of laws of nature (and not singularism) that allows for the possibility of indeterminism.
Scoring model to predict risk of chronic kidney disease in Chinese health screening examinees with type 2 diabetes
Authors: Cao Xia , Yang Binfang , Zhou Jiansong 
Published: November 2021

Abstract
Purpose
As health screening continues to increase in China, there is an opportunity to integrate a large number of demographic as well as subjective and objective clinical data into risk prediction modeling. The aim of this study was to develop and validate a prediction model for chronic kidney disease (CKD) in Chinese health screening examinees with type 2 diabetes mellitus (T2DM).

Methods
We conducted a retrospective cohort study consisting of 2051 Chinese T2DM patients between 35 and 78 years old who were enrolled in the XY3CKD Follow-up Program between 2009 and 2010. All participants were randomly assigned into a derivation set or a validation set at a 2:1 ratio. Cox proportional hazards regression model was selected for the analysis of risk factors for the development of the proposed risk model of CKD. We established a prediction model with a scoring system following the steps proposed by the Framingham Heart Study.

Results
The mean follow-up was 8.52 years, with a total of 315 (23.20%) and 189 (27.27%) incident CKD cases in the derivation set and validation set, respectively. We identified the following risk factors: age, gender, body mass index, duration of type 2 diabetes, variation of fasting blood glucose, stroke, and hypertension. The points were summed to obtain individual scores (from 0 to 15). The areas under the curve of 3-, 5- and 10-year CKD risks were 0.843, 0.799 and 0.780 in the derivation set and 0.871, 0.803 and 0.785 in the validation set, respectively.

Conclusions
The proposed scoring system is a promising tool for further application of assisting Chinese medical staff for early prevention of T2DM complications among health screening examinees.
Slag Properties in the Primary Production Process of Mn-Ferroalloys
Authors: Tangstad Merete , Bublik Sergey , Haghdani Shokouh , Einarsrud Kristian Etienne , Tang Kai 
Published: November 2021

Abstract
The thermodynamic and kinetic properties of the carbothermic reduction of MnO in the five-component slag, MnO-SiO2-CaO-MgO-Al2O3, is critical in the production process of Mn-ferroalloys. While the reduction rate is mainly dependent on the presence of a solid MnO phase in the slag for Mn-Fe-alloys, the rate for the Mn-Si-Fe alloys has two distinct steps, a slow step followed by a fast step. The extent of the slow step has been shown to be dependent on the S content in the slag. The thermo-physical properties of viscosity, density, interfacial tension and electrical resistivity is reviewed, and these properties are mainly determined by the total basicity.
Frail by different measures: a comparison of 8-year mortality in The Irish Longitudinal Study on Ageing (TILDA)
Authors: Romero-Ortuno Roman , Hartley Peter , Kenny Rose Anne , O’Halloran Aisling M. 
Published: November 2021

Abstract
Purpose
We compared the ability of four frailty identification tools (frailty phenotype: FP; FRAIL scale; 32-item Frailty Index: FI; and Clinical Frailty Scale: CFS) to predict 8-year mortality in TILDA.

Methods
We included wave 1 (2010) participants with data for all four tools. Mortality was ascertained at wave 5 (2018). Age, sex and education-adjusted binary logistic regression models were computed.

Results
At baseline, there were 5700 participants (mean age 63, range 50–98, 54% women). Frailty prevalences were 2.3% by FRAIL, 3.8% by FP, 10.9% by CFS, and 12.8% by FI. Mortality was 41.2%, 44.9%, 25.3% and 27.0%, respectively. The highest adjusted OR for mortality was for FRAIL (OR 4.48, 95% CI 2.93–6.85, P < 0.001), followed by FP (OR 3.55, 95% CI 2.52–5.00, P < 0.001), FI (OR 2.10, 95% CI 1.68–2.62, P < 0.001), and CFS (OR 1.88, 95% CI 1.48–2.38, P < 0.001).

Conclusions
All tools significantly predicted mortality, but FRAIL and FP seemed more specific.
‘Driven Insane by Eddyism’: Christian Science, Popular Psychopathology, and a Turn-of-the-Century Contest over Faith and Madness
Authors: Prince Alexandra 
Published: November 2021

ABSTRACTAt the turn of the twentieth century, Christian Scientists contended with ongoing allegations that their faith was more of a mental pathology than a religion. This article analyzes how the Church of Christ, Scientist, in particular its public relations branch the Committee on Publication, systematically contended with popular portrayals of Christian Science as a source or indicator of insanity. Two highly profiled court cases, both predicated on the purported insanity of a Christian Science woman and her attendant inability to manage her business affairs, are explored for their cultural effect on the promotion of the causal association between Christian Science and madness. This study employs newspaper clippings collected and archived by the Church's Committee on Publication as well as court records to argue for the salience of the insanity charge in shaping the early history of Christian Science and its public perception. As a religious tradition premised on divine healing and health, popular psychopathological interpretations of Christian Science were particularly subversive and functioned not only to discredit and undermine the religion's claims to healing but to forward societal fears that Christian Science study posed a unique threat to women's health. This examination draws attention to a dynamic historical exchange between the press and a new religious movement, as well as the polyvalent gendered presumptions embedded in popular charges of insanity in association with religion.
Neuropsychological differences between treatment-resistant and treatment-responsive schizophrenia: a meta-analysis
Authors: Millgate Edward , Hide Olga , Lawrie Stephen M , Murray Robin M , MacCabe James H , Kravariti Eugenia 
Published: November 2021

AbstractAntipsychotic treatment resistance affects up to a third of individuals with schizophrenia. Of those affected, 70–84% are reported to be treatment resistant from the outset. This raises the possibility that the neurobiological mechanisms of treatment resistance emerge before the onset of psychosis and have a neurodevelopmental origin. Neuropsychological investigations can offer important insights into the nature, origin and pathophysiology of treatment-resistant schizophrenia (TRS), but methodological limitations in a still emergent field of research have obscured the neuropsychological discriminability of TRS. We report on the first systematic review and meta-analysis to investigate neuropsychological differences between TRS patients and treatment-responsive controls across 17 published studies (1864 participants). Five meta-analyses were performed in relation to (1) executive function, (2) general cognitive function, (3) attention, working memory and processing speed, (4) verbal memory and learning, and (5) visual−spatial memory and learning. Small-to-moderate effect sizes emerged for all domains. Similarly to previous comparisons between unselected, drug-naïve and first-episode schizophrenia samples v. healthy controls in the literature, the largest effect size was observed in verbal memory and learning [dl = −0.53; 95% confidence interval (CI) −0.29 to −0.76; z = 4.42; p < 0.001]. A sub-analysis of language-related functions, extracted from across the primary domains, yielded a comparable effect size (dl = −0.53, 95% CI −0.82 to −0.23; z = 3.45; p < 0.001). Manipulating our sampling strategy to include or exclude samples selected for clozapine response did not affect the pattern of findings. Our findings are discussed in relation to possible aetiological contributions to TRS.
Q2DW‐Tide and ‐Ionosphere Interactions as Observed From ICON and Ground‐Based Radars
Authors: Forbes Jeffrey M. , Heelis Roderick , Zhang Xiaoli , Englert Christoph R. , Harding Brian J. , He Maosheng , Chau Jorge L. , Stoneback Russell , Harlander John M. , Marr Kenneth D. , Makela Jonathan J. , Immel Thomas J. 
Published: November 2021

AbstractA quasi‐2‐day wave (Q2DW) event during January‐February, 2020, is investigated in terms of its propagation from 96 to 250 km as a function of latitude (10°S to 30°N), its nonlinear interactions with migrating tides to produce 16 and 9.6‐h secondary waves (SWs), and the plasma drift and density perturbations that it produces in the topside F‐region (590–607 km) between magnetic latitudes 18°S and 18°N. This is accomplished through analysis of coincident Ionospheric Connections Explorer (ICON) measurements of neutral winds, plasma drifts and ion densities, and wind measurements from four low‐latitude (±15°) specular meteor radars (SMRs). The Q2DW westward‐propagating components that existed during this period consist of zonal wavenumberss = 2 ands = 3, that is, Q2DW+2 and Q2DW+3 (e.g., He, Chau et al., 2021,https://doi.org/10.1029/93jd00380). SWs in the ICON measurements are inferred from Q2DW+2 and Q2DW+3 characteristics derived from traditional longitude‐UT fits that potentially contain aliasing contributions from SWs (“apparent” Q2DWs), from fits to space‐based zonal wavenumbers that each reflect the aggregate signature of either Q2DW+2 or Q2DW+3 and its SWs combined (“effective” Q2DWs), and based on information contained in published numerical simulations. The total Q2DW ionospheric responses consists of F‐region field‐aligned and meridional drifts of order ±25 ms−1and ±5–7 ms−1, respectively, and total ion density perturbations of order (±10%–25%). It is shown that the SWs can sometimes make substantial contributions to the Q2DW winds, drifts, and plasma densities.
Biogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior
Authors: Teng Teng , Clarke Gerard , Maes Michael , Jiang Yuanliang , Wang Jun , Li Xuemei , Yin Bangmin , Xiang Yajie , Fan Li , Liu Xueer , Wang Jie , Liu Shouhuan , Huang Yunqing , Licinio Julio , Zhou Xinyu , Xie Peng 
Published: November 2021

AbstractMost previous studies in the pathophysiology of major depressive disorder (MDD) focused on fecal samples, which limit the identification of the gut mucosal and luminal microbiome in depression. Here, we address this knowledge gap. Male cynomolgus macaques (Macaca fascicularis) were randomly assigned to a chronic unpredictable mild stress (CUMS) group, or to an unstressed control group. Behavioral tests were completed in both groups. At endpoint, microbe composition of paired mucosal and luminal samples from cecum, ascending, transverse, and descending colons were determined by 16S ribosomal RNA gene sequencing. The levels of 34 metabolites involved in carbohydrate or energy metabolism in luminal samples were measured by targeted metabolomics profiling. CUMS macaques demonstrated significantly more depressive-like behaviors than controls. We found differences in mucosal and luminal microbial composition between the two groups, which were characterized by Firmicutes and Bacteriodetes at the phylum level, as well as Prevotellaceae and Lachnospiraceae at the family level. The majority of discriminative microbes correlated with the depressive-like behavioral phenotype. In addition, we found 27 significantly different microbiome community functions between the two groups in mucosa, and one in lumen, which were mainly involved in carbohydrate and energy metabolism. A total of nine metabolites involved in these pathways were depleted in CUMS animals. Together, CUMS macaques with depressive-like behaviors associated with distinct alterations of covarying microbiota, carbohydrate and energy metabolism in mucosa and lumen. Further studies should focus on the mucosal and luminal microbiome to provide a deeper spatiotemporal perspective of microbial alterations in the pathogenesis of MDD.
A draft genome, resequencing, and metabolomes reveal the genetic background and molecular basis of the nutritional and medicinal properties of loquat (Eriobotrya japonica (Thunb.) Lindl)
Authors: Wang Yunsheng 
Published: November 2021

AbstractLoquat (Eriobotrya japonica) is a popular fruit and medicinal plant. Here, a high-quality draft genome of theE. japonica‘Big Five-pointed Star’ cultivar that covers ~98% (733.32 Mb) of the estimated genome size (749.25 Mb) and contains a total of 45,492 protein-coding genes is reported. Comparative genomic analysis suggests that the loquat genome has evolved a unique genetic mechanism of chromosome repair. Resequencing data from 52 loquat cultivars, including 16 white-fleshed and 36 yellow-fleshed variants, were analyzed, and the flower, leaf, and root metabolomes of ‘Big Five-pointed Star’ were determined using a UPLC-ESI-MS/M system. A genome-wide association study identified several candidate genes associated with flesh color inE. japonica, linking these phenotypes to sugar metabolism. A total of 577 metabolites, including 98 phenolic acids, 95 flavonoids, and 28 terpenoids, were found, and 191 metabolites, including 46 phenolic acids, 33 flavonoids, and 7 terpenoids, showed no differences in concentration among the leaves, roots, and flowers. Candidate genes related to the biosynthesis of various medicinal ingredients, such as phenolics, flavonoids, terpenoids, and polysaccharides, were identified. Some of these genes were confirmed to be members of expanding gene families, suggesting that the high concentrations of beneficial metabolites in loquat may be associated with the number of biosynthetic genes in this plant. In summary, this study provides fundamental molecular insights into the nutritional and medical properties ofE. japonica.