bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erworbenes transientes Fanconi-Syndrom nach Fütterung von Trockenfleisch als Leckerchen beim Hund
Authors: Schaalo Stephanie , Miklis Alexandra , Schlüter Charlotte , Neiger Reto 
Published: August 2021

ZusammenfassungZwischen April 2018 und August 2019 wurden 6 Hunde mit labordiagnostischen Hinweisen auf ein Fanconi-Syndrom in der Tierklinik Hofheim vorgestellt. In allen Fällen ließ sich der Verdacht mittels Untersuchung der Aminosäuren im Harn bestätigen. Bei 5 der 6 Hunde bestand der hochgradige Verdacht auf eine alimentäre Genese, bei 3 Hunden konnte der Verlauf der Krankheit verfolgt werden. Durch unterstützende therapeutische Maßnahmen und Elimination der Leckerchen aus Trockenfleisch vom Speiseplan besserte sich die klinische Symptomatik bei den Hunden mit Verlaufskontrolle. Hierbei handelt es sich um die erste Fallserie von in Deutschland erkrankten Hunden. Die Häufigkeit des Auftretens des Fanconi-Syndroms in etwas mehr als einem Jahr in nur einer Tierklink lässt eine deutlich höhere Inzidenz vermuten, als derzeit angenommen wird.
Cold snare polypectomy without submucosal injection: safety and efficacy in 615 large serrated lesions
Authors: Barros Roberto Augusto , Monteverde Maria Jose , Dumonceau Jean-Marc , Barros Augusto Sebastian , Rainero German Luis , Barros Roberto Federico , Jaroslavsky Maria Jose , de Elizalde Santiago 
Published: August 2021

Abstract
Background and study aim Cold resection is becoming the standard of care for the resection of nonpedunculated colon lesions up to 10 mm in diameter. Sessile serrated adenomas/polyps (SSA/Ps), including those ≥ 10 mm, present various characteristics that make them ideal candidates for cold snare polypectomy (CSP).
Patients and methods A prospectively maintained database was searched retrospectively for consecutive patients with lesions ≥ 10 mm resected between March 2013 and March 2018. During that period, all SSA/P-appearing lesions were resected using CSP without submucosal injection, except for lesions with endoscopic suspicion of dysplasia or submucosal invasion. Patients with a pathological diagnosis of SSA/P were included in the analysis. Adverse events were recorded up to 21 days following colonoscopy.
Results 615 SSA/Ps ≥ 10 mm were resected during 452 colonoscopy procedures in 379 patients (mean age 54.1 years; standard deviation [SD] 11.9 years). Mean polyp size was 13.7 (SD 5.2) mm; 122 lesions (19.8 %) were ≥ 20 mm and 479 lesions (77.9 %) underwent piecemeal resection. Immediate adverse events included persistent abdominal pain that resolved spontaneously within 2 hours in three patients (0.8 %; 95 % confidence interval [CI] 0.2 %–2.3 %). One patient with persistent intraprocedural bleeding was successfully treated with a hemostatic clip. No late adverse events were detected. Surveillance colonoscopy was performed in 293 patients (77.3 %) at 23.4 (SD 11.6) months following index colonoscopy; residual/recurrent lesions were diagnosed in 23 patients (7.8 %; 95 %CI 5.0 %–11.6 %).
Conclusion CSP without submucosal injection appeared to be safe and effective for the resection of large SSA/Ps.
Mangankonzentrationen im Vollblut, Plasma und Serum adulter Warmblutpferde an 3 Standorten in Deutschland
Authors: Theiner Elena , Weber Corinna , Müller Elisabeth , Venner Monica , Vervuert Ingrid 
Published: August 2021

Zusammenfassung
Ziel Etablierung von Referenzintervallen für Mangan (Mn) im Serum, Plasma und Vollblut bei adulten, gesunden Warmblutpferden mit bekannter Mn-Aufnahme und Vergleich von 2 analytischen Methoden der Mn-Bestimmung im Blut.
Material und Methoden Zwischen Mai 2018 und November 2019 erfolgte auf 3 Gestüten bei 270 gesunden Pferden im Alter von 3–25 Jahren eine einmalige Blutprobenentnahme. In Vollblut, Plasma (Antikoagulans jeweils Lithium-Heparin [LH]) und Serum wurden die Mn-Konzentrationen mittels Massenspektrometrie mit induktiv gekoppeltem Plasma (ICP-MS) sowie mittels Atomabsorptionsspektrometrie (AAS) bestimmt. Die Referenzintervalle für jedes Substrat wurden nach den Empfehlungen der International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) und des Clinical and Laboratory Standards Institute (CLSI) berechnet (Bereich zwischen 2,5- und 97,5-Perzentil der analysierten Mn-Blutkonzentration). Zeitgleich mit der Blutprobenentnahme wurden repräsentative Futterproben entnommen, um den Mn-Gehalt der korrespondierenden Fütterung zu bestimmen.
Ergebnisse Die Pferde zeigten im Vollblut mit einer medianen Mn-Konzentration von 12,4 µg/l (Referenzintervall: 4,99–25,1 µg/l [AAS]; 5,99–25,3 µg/l [ICP-MS]) signifikant höhere Mn-Konzentrationen (p < 0,0001) als im korrespondierenden Serum (Median: 1,65 µg/l, Referenzintervall: 0,60–3,50 µg/l [AAS]; 1,11–2,96 µg/l [ICP-MS]) oder LH-Plasma (Median: 1,35 µg/l, Referenzintervall: 0,22–2,68 µg/l [AAS]; 0,59–2,45 µg/l [ICP-MS]). Im Methodenvergleich ergaben sich für LH-Plasma und Serum zwischen der AAS und der ICP-MS statistisch signifikante Abweichungen in den Mn-Bestimmungen, wohingegen sie für das Vollblut vergleichbare Ergebnisse lieferten.
Schlussfolgerung und klinische Relevanz Vollblut weist durchschnittlich 10-fach höhere Mn-Konzentrationen auf als Serum oder LH-Plasma. Bei der Bewertung von Mn-Konzentrationen im Blut muss daher berücksichtigt werden, welches Probenmaterial analysiert wurde und welche Methode zur Anwendung kam, da in Serum und Plasma zwischen AAS und ICP-MS relevante Unterschiede auftreten können.
Zistrosenextrakt zur Prophylaxe einer SARS-CoV-2-Infektion
Authors: Träder Jens-Martin 
Published: August 2021

ZusammenfassungUntersuchungen haben gezeigt, dass sich ein spezieller Extrakt aus Cistus × incanus L. in vitro als effektiv gegen SARS-CoV-2 erwiesen hat. Da die enthaltenen hochpolymeren Polyphenole unspezifisch mit der Virusoberfläche interagieren und dadurch den Eintritt in die Zelle verhindern (Entry-Inhibitor), ist auch eine Wirkung gegen die neuen SARS-CoV-2-Varianten wahrscheinlich.Um dies zu verifizieren, wurde am Institut für Medizinische Virologie der Goethe-Universität in einem Zellmodell mit menschlichen Darmzellen (Caco-2) die Inhibition des cytopathischen Effekts (CPE) durch den Zistrosenextrakt untersucht. Es konnte eine fast vollständige Hemmung des Viruswachstums bei Konzentrationen von mehr als 100 µg/ml bei beiden Varianten beobachtet werden. Die errechnete EC50 (mittlere effektive Konzentration) liegt für die britische Variante (B.1.1.7) bei 48,9 µg/ml und für die südafrikanische Variante (B.1.351) bei 45,2 µg/ml. Aufgrund der hohen In-vitro-Aktivität auch gegen die neuen Varianten erscheint es sinnvoll, den Zistrosenextrakt lokal als Prophylaxe gegen Infektionen mit SARS-CoV-2 einzusetzen.
Schmerzbewertung bei der Kastration von Pferden
Authors: Längerer Lina 
Published: August 2021

Dalla Costa E, Dai F, Lecchi C et al. Towards an improved pain assessment in castrated horses using facial expressions (HGS) and circulating miRNAs. Vet Rec 2021; 188 (9): e82
Ziel dieser Studie war eine Verbesserung der Schmerzbeurteilung und der Analgesie im Rahmen der Kastration von Hengsten. Die analgetische Behandlung wurde anhand der equinen Schmerzgesicht-Skala (horse grimace scale, HGS), der zusammengesetzten Schmerzskala (composite pain scale, CPS) und der Konzentrationen spezifischer im Blut zirkulierender Micro-RNAs (miRNAs) beurteilt. In der Pferdemedizin werden miRNAs als innovativer Ansatz zur Bestimmung von akuten Schmerzen untersucht. So fiel bei Pferden mit akuter Hufrehe ein Anstieg der zirkulierenden miR-23b-3p, miR-145–5p und miR-200b-3p auf. Weitere Studien zu diesen molekularen Indikatoren sind erforderlich, um besser zu verstehen, ob ihre Modulation mit der akuten Schmerzwahrnehmung, Entzündung oder beidem zusammenhängt. Diesbezüglich sind neue Erkenntnisse entscheidend für den Beginn einer effektiven Schmerzbewertung.
Ängste homöopathisch behandeln
Authors: Boeddri Ute 
Published: August 2021

ZusammenfassungAngst ist ein evolutionär elementares Gefühl und gehört zum Leben. Im Laufe des Lebens lernt man aus den Erfahrungen heraus, damit umzugehen. Die diffuse Angst kann sich jedoch zur konkreten Furcht entwickeln. Am Beispiel der Ängste von Kindern und Jugendlichen werden in diesem Artikel einige medikamentöse Therapiemöglichkeiten in Form von Einzelhomöopathika und fixen Kombinationen vorgestellt.Im Lüscher-Farbtest lässt sich das pathologische Selbstwertgefühl entdecken, das hinter der Angst steht.
Comparison of the Efficacy of Septoplasty with Nonsurgical Management in Improving Nasal Obstruction in Patients with Deviated Nasal Septum – A Randomized Clinical Trial
Authors: Srinivasan Dharanya Gopalakrishnan , Hegde Jyotirmay , Ramasamy Karthikeyan , Raja Kalaiarasi , Rajaa Sathish , Ganesan Sivaraman , Velayutham Prabu , Alexander Arun , Saxena Sunil Kumar 
Published: August 2021

Abstract
Introduction In the current era, the major indication for septoplasty is nasal obstruction due to deviated nasal septum (DNS). Even though septoplasty is a commonly performed surgery, its effectiveness in relieving nasal obstruction in DNS has not been proven.
Objective The present study involved the measurement of both objective (nasal patency) and subjective (quality of life measures) outcome measures for the evaluation of the efficacy of septoplasty as compared with medical management.
Methods Patients with DNS presenting with nasal obstruction were included and randomized into a septoplasty group or into a nonsurgical management group, with 70 patients in each group. The improvement in nasal obstruction was assessed subjectively by the visual analogue scale (VAS), and the sino-nasal outcome test-22 (SNOT-22) and the nasal obstruction symptom evaluation (NOSE) questionnaires and was measured objectively by assessment of nasal patency by peak nasal inspiratory flow (PNIF) at 0, 1, 3, and 6 months of treatment in both groups.
Results The average VAS, SNOT-22 and NOSE scores for the septoplasty versus the nonsurgical group before treatment were 6.28 versus 6.0, 19.5 versus 15, and 14 versus 12, respectively, and at 6 months post-treatment, the scores were 2.9 versus 5.26, 10 versus 12, and 8 versus 10 (p = 0.001), respectively. The average PNIF scores at 0 and 6 months were 60/50 l/min and 70/60 l/min, respectively, in the septoplasty group (p = 0.001); the scores at 0 and 6 months in the nonsurgical management group were 60/60 l/min and 70/70 l/min, respectively (p = 0.001).
Conclusion Surgical correction of DNS by septoplasty improves nasal obstruction better than nonsurgical management at 6 months postsurgery.
Selecting the Right Plane of Dissection in Thyroidectomy: Along the Recurrent Laryngeal Nerve or the Thyroid Capsule? A Retrospective Analysis
Authors: Waseem Talat , Ahmed Safia Zahir , Zahara Fatima Tuz , Ashraf Muhammad Hasham , Azim Khwaja Muhammad 
Published: August 2021

AbstractIntroduction Total thyroidectomy remains highly technical, with a significant risk of recurrent laryngeal nerve (RLN) compromise and hypoparathyroidism. After identifying RLN, at the level of the ligament of Berry, local factors may compel the surgeon to either dissect along the nerve or the thyroid capsule.Objective The objective of the present study is to compare these two approaches in terms of outcomes and complication rates.Methods This is a retrospective analysis from September, 2013 to April 2019 of 511 consecutive patients undergoing thyroidectomy. General demographics and disease parameters were recorded. At the discretion of the surgeon and according to the demands of the local operative factors, the patients either had dissection along the RLN or along the thyroid capsule. Perioperative and postoperative parameters such as blood loss, duration of surgery, hospital stay, pain scores, analgesia requirements and complications were recorded. The groups were compared with the Pearson chi-squared test or with the Fisher exact test. A p-value < 0.05 was considered statistically significant.Results The incidence of transient hypocalcaemia and transient RLN compromise were higher when dissection was performed along the nerve as opposed to the plane along the thyroid capsule. Other parameters including operative time, hospital stay, pain scores, analgesia requirement, wound infection, seroma, hemorrhage, and recurrence did not differ between the groups. Subgroup analysis of the patients who presented with complications showed that local factors, malignancy, and extent of surgery correlated positively with complications when dissected along the RLN.Conclusion Dissection along the capsule of the thyroid during thyroidectomy is a safer plane in terms of low rate of transient RLN injury and hypoparathyroidism as opposed to dissection along the nerve.
The Pipeline for Standardizing Russian Unstructured Allergy Anamnesis Using FHIR AllergyIntolerance Resource
Authors: Lenivtceva Iuliia D. , Kopanitsa Georgy 
Published: August 2021

Abstract
Background The larger part of essential medical knowledge is stored as free text which is complicated to process. Standardization of medical narratives is an important task for data exchange, integration, and semantic interoperability.
Objectives The article aims to develop the end-to-end pipeline for structuring Russian free-text allergy anamnesis using international standards.
Methods The pipeline for free-text data standardization is based on FHIR (Fast Healthcare Interoperability Resources) and SNOMED CT (Systematized Nomenclature of Medicine Clinical Terms) to ensure semantic interoperability. The pipeline solves common tasks such as data preprocessing, classification, categorization, entities extraction, and semantic codes assignment. Machine learning methods, rule-based, and dictionary-based approaches were used to compose the pipeline. The pipeline was evaluated on 166 randomly chosen medical records.
Results AllergyIntolerance resource was used to represent allergy anamnesis. The module for data preprocessing included the dictionary with over 90,000 words, including specific medication terms, and more than 20 regular expressions for errors correction, classification, and categorization modules resulted in four dictionaries with allergy terms (total 2,675 terms), which were mapped to SNOMED CT concepts. F-scores for different steps are: 0.945 for filtering, 0.90 to 0.96 for allergy categorization, 0.90 and 0.93 for allergens reactions extraction, respectively. The allergy terminology coverage is more than 95%.
Conclusion The proposed pipeline is a step to ensure semantic interoperability of Russian free-text medical records and could be effective in standardization systems for further data exchange and integration.
Utility of Digital Breast Tomosynthesis with Two-Dimensional Synthesized Mammography Images: A Pictorial Essay
Authors: Hande Pradipta C. , Desai Sabita S. , Arneja Sarabjeet K. , Sathian Sreedevi 
Published: August 2021

Abstract
Background Mammography has been established as the key modality in the detection and diagnosis of breast cancers. Digital breast tomosynthesis (DBT) has emerged as a mammographic technique which allows improved visualization of abnormalities by reducing the effect of overlapping breast tissue.
Purpose This article is a pictorial essay which highlights the advantages of DBT with two-dimensional (2D) synthesized mammography (2DSM) images, its clinical applications, and its role in breast imaging.
Materials and Methods Selenia Dimensions HD mammography machine performs DBT which acquires a series of low-dose digital mammographic images of the compressed breast followed by full-field digital mammography. Software using specialized algorithms helps to create a 2DSM image reconstructed from the DBT data set. The images are interpreted on a dedicated work station on high-resolution monitors by the radiologist. American College of Radiology Breast Imaging-Reporting and Data System (BI-RADS) lexicon is used for reporting. High-resolution breast ultrasound which includes evaluation of the axilla is done for all cases.
Conclusion DBT improves detection and better characterization of lesions which thereby increases confidence of interpretation of mammograms and assigning BI-RADS categories for further management.
Myocardial Infarction or Takotsubo Cardiomyopathy? A Case Report of a Rare Clinical Dilemma in the Setting of Atrial Myxoma
Authors: Ganesh Balasubramaniyan Amirtha , Rangasamy Sasinthar , Aashish Arumugam , Karthikeyan Selvaraj 
Published: August 2021

Abstract

Background Acute myocardial infarction (AMI) secondary to coronary embolization is one of the rare complications of atrial myxoma. Takotsubo cardiomyopathy (TCM), a close mimic of AMI, is extremely rare in the setting of atrial myxoma. We report a patient with atrial myxoma presenting with features leading to a clinical dilemma between these two entities.

Case summary  A 60-year-old woman presented with acute chest pain with ST segment elevation. Echocardiogram revealed left ventricular (LV) apical ballooning which is typical of TCM, coexisting with a fragile left atrial mass. Emergency coronary angiogram showed a hazy lesion in the circumflex ostium and an intermediate lesion in ramus without any obstruction. Surgical excision of the tumor was done due to features of recurrent coronary embolism. The histopathology examination confirmed it as a myxoma. Regional wall motion abnormalities reversed within a month and LV function normalized. Cardiac magnetic resonance (CMR) imaging at follow-up suggested myocardial infarction.

Discussion TCM can occur very rarely in the setting of atrial myxoma. In a patient with atrial myxoma presenting with features of TCM, differentiating it from coronary embolization is important.
Assessing the Influence of Failed Implant Reconstruction on Patient Satisfaction and Decision Regret after Salvage Free-Flap Breast Reconstruction
Authors: Shammas Ronnie L. , Sergesketter Amanda R. , Taskindoust Mahsa , Biswas Sonali , Hollenbeck Scott T. , Phillips Brett T. 
Published: August 2021

Abstract
Background Free-flap breast reconstruction after failed implant reconstruction is associated with improved patient outcomes. How the level of satisfaction achieved compares between patients with and without previously failed implant reconstruction remains unknown. The aim of this study was to assess the influence of prior failed implant-based reconstruction on long-term patient-reported outcomes after free-flap breast reconstruction.
Methods All patients undergoing free-flap breast reconstruction between 2015 and 2019 were identified. Patient satisfaction using the BREAST-Q and decisional regret using the Decision Regret Scale were compared between patients with and without a history of implant breast reconstruction.
Results Overall, 207 patients were contacted and 131 completed the BREAST-Q and Decision Regret Scale. A total of 23 patients had a history of failed implant-based reconstruction requiring free-flap-flap salvage, most commonly due to infection (39.1%), chronic pain (34.8%), capsular contracture (26%), and implant malposition (26.1%). Following definitive free-flap reconstruction, patients with prior failed implant reconstruction had significantly lower BREAST-Q scores for satisfaction with breast (61.2 ± 16.7 vs. 70.4 ± 18.7; p = 0.04) and sexual well-being (38.5 ± 18.2 vs. 52.8 ± 24.7; p = 0.01) and reported higher decision regret (19.1 ± 18.6 vs. 9.6 ± 15.6, respectively). There were no significant differences for psychosocial well-being (p = 0.67), physical well-being (chest; p = 0.27), and physical well-being (abdomen; p = 0.91).
Conclusion A history of failed implant-based reconstruction is associated with reduced satisfaction and increased decision regret with the final reconstructive outcome. This data underscores the importance of appropriate patient selection at the initial consultation, and informed preoperative counseling regarding long-term outcomes in patients presenting for free-flap reconstruction after a failed implant-based reconstruction.
Clock proteins and training modify exercise capacity in a daytime-dependent manner
Authors: Adamovich Yaarit , Dandavate Vaishnavi , Ezagouri Saar , Manella Gal , Zwighaft Ziv , Sobel Jonathan , Kuperman Yael , Golik Marina , Auerbach Asher , Itkin Maxim , Malitsky Sergey , Asher Gad 
Published: August 2021

Significance
Studies in mice and humans have revealed daytime variance in exercise performance, yet it is still unclear whether and how these daytime differences are regulated by the circadian clock. Here, we show that exercise performance is circadian clock controlled and that specific clock proteins modify exercise capacity in a time-dependent manner, likely through differences in food consumption and liver glycogen stores. We also demonstrate that the time of day at which training is performed plays a role in improving exercise capacity. Our study suggests that exercise capacity is shaped by clock proteins and training in a daytime-dependent manner.
Unearthing real-time 3D ant tunneling mechanics
Authors: Buarque de Macedo Robert , Andò Edward , Joy Shilpa , Viggiani Gioacchino , Pal Raj Kumar , Parker Joseph , Andrade José E. 
Published: August 2021

Significance
Predicting the stability of granular materials under particle removal has wide-reaching applications, including automating tunnel excavations. Searching for general laws that govern granular stability is challenging given the complexity of granular material dynamics. However, knowledge may be gained from the natural world, where organisms have evolved adaptive tunneling strategies. Among these, subterranean-nesting ants execute an innate tunneling behavioral program that can lead to remarkably stable tunnel excavation. We use X-rays to image the process of ant tunnel construction through a particulate substrate. We use these data to create a grain-scale accurate simulation for estimating particle mechanics in the sample during real-time excavation. We present evidence that ants benefit from force redistributions during incremental digging, suggesting techniques for robotic mining.
Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy
Authors: Liu Lin , Koike Hiroyuki , Ono Takehito , Hayashi Shinichiro , Kudo Fujimi , Kaneda Atsushi , Kagechika Hiroyuki , Manabe Ichiro , Nakashima Tomoki , Oishi Yumiko 
Published: August 2021

SignificanceSkeletal muscle atrophy occurs as a result of a variety of conditions including aging, disuse, and cachexia. In this study, we show that the transcription factor KLF5 is transiently up-regulated by metabolic and disuse stimulations and plays a pivotal role in the onset of muscle atrophy in vitro and in vivo. KLF5 physically interacts with Foxo1, and together, they regulate the transcription ofFbxo32, a key atrophy-inducing ubiquitin ligase. A synthetic retinoid, Am80, attenuates muscle atrophy in vitro and in vivo. Moreover, publicly available data sets showed that in humans,KLF5expression significantly increased with aging and with sarcopenia and correlated positively with expression of the ubiquitin ligase genesFBXO32andTRIM63.
Monkeys exhibit a paradoxical decrease in performance in high-stakes scenarios
Authors: Smoulder Adam L. , Pavlovsky Nicholas P. , Marino Patrick J. , Degenhart Alan D. , McClain Nicole T. , Batista Aaron P. , Chase Steven M. 
Published: August 2021

Significance
Choking under pressure is a frustrating phenomenon experienced sometimes by skilled performers as well as during everyday life. The phenomenon has been extensively studied in humans, but it has not been previously shown whether animals also choke under pressure. Here we report that rhesus monkeys also choke under pressure. This indicates that there may be shared neural mechanisms that underlie the behavior in both humans and monkeys. Introducing an animal model for choking under pressure allows for opportunities to study the neural causes of this paradoxical behavior.