bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)
Authors: Albrecht Fenja , Wolters Heidi , Ziert Yvonne , Timmermann Beate , Kortmann Rolf-Dieter , Matuschek Christiane , Rübe Christian , Martini Carmen , Christiansen Hans , Eich Hans Theodor , Willich Normann , Steinmann Diana 
Published: June 2021

Abstract
Purpose
The aim of the study is to evaluate treatment-related acute and late eye toxicity associated with radiation therapy in childhood and adolescence as correlated with RT (radiotherapy) doses.

Methods
From 2001 to 2016, a total of 1725 children and adolescents undergoing radiation therapy were prospectively documented in the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK). The RTOG/EORTC criteria were used to classify ocular acute and late effects. Uni- and multivariate analyses were carried out to evaluate the impact of patient age, pre-existing impairments, and radiation dose on ocular toxicity.

Results
Of all documented patients, 593 received dose to the eye and formed the basis of this analysis. In 435 patients, information on acute reaction was available and graded 1, 2, 3, and 4 in 49, 17, 0, and 2 patients, respectively. Information on late toxicity was available in 268 patients and graded 1, 2, 3, and 4 in 15, 11, 11, and 5 patients, respectively. The acute toxicity rate was significantly higher in children who received a maximum dose > 50 Gy to the eye (p < 0.001) and who had a pre-existing eye impairment (p < 0.001 in multivariate analysis). The development of late toxicity was significantly higher for patients experiencing acute toxicity and having received a radiation dose > 50 Gy.

Conclusion
Acute and late toxicity both correlate with high radiation dose to the eye (> 50 Gy) and acute toxicity additionally with pre-existing eye impairments.
Grenzbereiche der Thrombektomie
Authors: Psychogios Marios-Nikos , Brehm Alex , Sporns Peter , Bonati Leo H. 
Published: June 2021

ZusammenfassungDie mechanische Thrombektomie (MT) hat sich als Standardverfahren für die Behandlung akuter ischämischer Schlaganfälle aufgrund eines Verschlusses einer großen, proximalen Hirnarterie der vorderen Zirkulation etabliert. Dennoch sind nach aktuellen Guidelines noch große Patientenkollektive von dieser hocheffektiven Behandlungsmethode ausgeschlossen. Diese Arbeit gibt daher einen Überblick über mögliche Erweiterungen der Behandlungsindikationen für die MT, wie z. B. Patienten im erweiterten Zeitfenster, mit distalen Verschlüssen, mit großem Infarktkern oder auch für sehr alte (> 90 Jahre) und junge (0–17 Jahre) Patienten. Zusätzlich besprechen wir neue Entwicklungen in der interventionellen Behandlung von Schlaganfällen, wie z. B. neue Triage-Konzepte oder die Fragestellung, ob die zusätzliche intravenöse Thrombolyse bei MT-Patienten notwendig ist. Abschließend geben wir für die besprochenen Behandlungsindikationen unsere Einschätzungen basierend auf der aktuellen Literatur und unserer klinischen Erfahrung.
Safety and Efficacy of Landiolol Hydrochloride in Children with Tachyarrhythmia of Various Etiologies
Authors: Ashida Atsuko , Ozaki Noriyasu , Kishi Kanta , Odanaka Yutaka , Nemoto Shintaro , Konishi Hayato , Ashida Akira 
Published: June 2021

AbstractThe safety and efficacy of landiolol have not been fully elucidated in pediatric patients. This study aimed to clarify the safety and efficacy of landiolol in a pediatric cohort. We retrospectively assessed the clinical features of 21 pediatric patients who were administered landiolol at our hospital. We also investigated the rates of sinus rhythm conversion and heart rate response. The median patient age was 7 months (interquartile range 1–13 months). The etiology of tachyarrhythmia was junctional ectopic tachycardia in 10 patients (47.6%), atrial tachycardia in 10 patients (47.6%), and ventricular tachycardia in 1 patient (4.8%). Of the 21 children, 18 (85.7%) had congenital heart defects, including 14 (77.8%) in whom a landiolol infusion was performed perioperatively. The landiolol infusion was effective in 18 pediatric patients (85.7%), as measured by the conversion to sinus rhythm or a reduced heart rate. Atrial tachycardia in the perioperative period was terminated in all patients. Of 7 patients with tachyarrhythmias unrelated to the perioperative period, landiolol was effective in 5. No adverse effects were reported in any patient. Landiolol infusion is effective and safe in pediatric patients with tachyarrhythmia of various etiologies, especially those with atrial tachyarrhythmia during the perioperative period.
Eosinophils in skin diseases
Authors: Radonjic-Hoesli Susanne , Brüggen Marie-Charlotte , Feldmeyer Laurence , Simon Hans-Uwe , Simon Dagmar 
Published: June 2021

AbstractEosinophil infiltration is a common finding in a broad spectrum of skin diseases, despite the fact that the skin is devoid of eosinophils under physiologic conditions. Although cutaneous eosinophilia is reactive, cytokine-mediated in most cases, diseases with an intrinsic mutation-mediated clonal expansion of eosinophils can also manifest on the skin. As eosinophils are involved in host defense, regulate immune responses, generate pruritus, induce remodeling and fibrosis, and can cause tissue damage, they have the capacity to actively contribute to the pathogenesis of diseases. Recent research provided deeper insights in the mechanisms, e.g., bacterial and viral clearance, blister formation, recruitment of cytotoxic T cells, and generation of pruritus, by which eosinophils might come into action. This review aims at providing an overview on the clinical presentations of eosinophil-associated dermatoses and the current understanding of their pathogenic role in these diseases. Further, we discuss the effects of therapies targeting eosinophils.
Factors of boreal summer latent heat flux variations over the tropical western North Pacific
Authors: Wang Yuqi , Wu Renguang 
Published: June 2021

AbstractSurface latent heat flux (LHF) is an important component in the heat exchange between the ocean and atmosphere over the tropical western North Pacific (WNP). The present study investigates the factors of seasonal mean LHF variations in boreal summer over the tropical WNP. Seasonal mean LHF is separated into two parts that are associated with low-frequency (> 90-day) and high-frequency (≤ 90-day) atmospheric variability, respectively. It is shown that low-frequency LHF variations are attributed to low-frequency surface wind and sea-air humidity difference, whereas high-frequency LHF variations are associated with both low-frequency surface wind speed and high-frequency wind intensity. A series of conceptual cases are constructed using different combinations of low- and high-frequency winds to inspect the respective effects of low-frequency wind and high-frequency wind amplitude to seasonal mean LHF variations. It is illustrated that high-frequency wind fluctuations contribute to seasonal high-frequency LHF only when their intensity exceeds the low-frequency wind speed under which there is seasonal accumulation of high-frequency LHF. When high-frequency wind intensity is smaller than the low-frequency wind speed, seasonal mean high-frequency LHF is negligible. Total seasonal mean LHF anomalies depend on relative contributions of low- and high-frequency atmospheric variations and have weak interannual variance over the tropical WNP due to cancellation of low- and high-frequency LHF anomalies.
Colchicin: altes Medikament mit neuem Nutzen
Authors: Boyadzhieva Z. , Ruffer N. , Krusche M. 
Published: June 2021

ZusammenfassungColchicin, das Gift der Herbstzeitlosen, hat verschiedene antiinflammatorische Effekte. Aus diesem Grund kommt es zur Behandlung von rheumatologischen Erkrankungen aus dem autoinflammatorischen Formenkreis, wie z. B. der Arthritis urica oder dem familiären Mittelmeerfieber (FMF), zum Einsatz. Darüber hinaus gibt es erste Daten, die einen positiven Nutzen von Colchicin bei kardiovaskulären Erkrankungen nahelegen. Des Weiteren werden aktuell verschiedene antiinflammatorische Therapieansätze in der COVID-19-Behandlung in Studien erprobt. Hier gibt es ebenfalls erste Publikationen, die einen potenziellen Nutzen von Colchicin in bestimmten Krankheitsphasen der Virusinfektion nahe legen. Dieser Beitrag will einen Überblick über die Wirkweise, den Nutzen und Nebenwirkungen sowie die verschiedenen Einsatzmöglichkeiten von Colchicin in der Rheumatologie geben. Weiterhin soll ein kurzer Ausblick in neue Einsatzgebiete dieses Medikamentes gegeben werden.
On the Stability Problem of Equilibrium Discrete Planar Curves
Authors: Jikumaru Yoshiki 
Published: June 2021

AbstractWe study planar polygonal curves with the variational methods. We show a unified interpretation of discrete curvatures and the Steiner-type formula by extracting the notion of the discrete curvature vector from the first variation of the length functional. Moreover, we determine the equilibrium curves for the length functional under the area-constraint condition and study their stability.
Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration – an in silico analysis
Authors: Perier-Metz Camille , Duda Georg N. , Checa Sara 
Published: June 2021

AbstractLarge bone defects remain a clinical challenge because they do not heal spontaneously. 3-D printed scaffolds are a promising treatment option for such critical defects. Recent scaffold design strategies have made use of computer modelling techniques to optimize scaffold design. In particular, scaffold geometries have been optimized to avoid mechanical failure and recently also to provide a distinct mechanical stimulation to cells within the scaffold pores. This way, mechanical strain levels are optimized to favour the bone tissue formation. However, bone regeneration is a highly dynamic process where the mechanical conditions immediately after surgery might not ensure optimal regeneration throughout healing. Here, we investigated in silico whether scaffolds presenting optimal mechanical conditions for bone regeneration immediately after surgery also present an optimal design for the full regeneration process. A computer framework, combining an automatic parametric scaffold design generation with a mechano-biological bone regeneration model, was developed to predict the level of regenerated bone volume for a large range of scaffold designs and to compare it with the scaffold pore volume fraction under favourable mechanical stimuli immediately after surgery. We found that many scaffold designs could be considered as highly beneficial for bone healing immediately after surgery; however, most of them did not show optimal bone formation in later regenerative phases. This study allowed to gain a more thorough understanding of the effect of scaffold geometry changes on bone regeneration and how to maximize regenerated bone volume in the long term.
The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide
Authors: Robles Juan Pablo , Zamora Magdalena , Siqueiros-Marquez Lourdes , Adan-Castro Elva , Ramirez-Hernandez Gabriela , Nuñez Francisco Freinet , Lopez-Casillas Fernando , Millar Robert P. , Bertsch Thomas , Martínez de la Escalera Gonzalo , Triebel Jakob , Clapp Carmen 
Published: June 2021

AbstractThe hormone prolactin acquires antiangiogenic and antivasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, an endogenous prolactin fragment of 123 or more amino acids that inhibits the action of multiple proangiogenic factors. Preclinical and clinical evidence supports the therapeutic potential of vasoinhibin against angiogenesis-related diseases including diabetic retinopathy, peripartum cardiomyopathy, rheumatoid arthritis, and cancer. However, the use of vasoinhibin in the clinic has been limited by difficulties in its production. Here, we removed this barrier to using vasoinhibin as a therapeutic agent by showing that a short linear motif of just three residues (His46-Gly47-Arg48) (HGR) is the functional determinant of vasoinhibin. The HGR motif is conserved throughout evolution, its mutation led to vasoinhibin loss of function, and oligopeptides containing this sequence inhibited angiogenesis and vasopermeability with the same potency as whole vasoinhibin. Furthermore, the oral administration of an optimized cyclic retro-inverse vasoinhibin heptapeptide containing HGR inhibited melanoma tumor growth and vascularization in mice and exhibited equal or higher antiangiogenic potency than other antiangiogenic molecules currently used as anti-cancer drugs in the clinic. Finally, by unveiling the mechanism that obscures the HGR motif in prolactin, we anticipate the development of vasoinhibin-specific antibodies to solve the on-going challenge of measuring endogenous vasoinhibin levels for diagnostic and interventional purposes, the design of vasoinhibin antagonists for managing insufficient angiogenesis, and the identification of putative therapeutic proteins containing HGR.
Tension-only ideal dissipative bracing for the seismic retrofit of precast industrial buildings
Authors: Dal Lago Bruno , Naveed Muhammad , Lamperti Tornaghi Marco 
Published: June 2021

AbstractNew precast frame industrial structures are seismically designed according to reliable modern criteria. However, most of the existing built stock hosting many workers and both regular and strategic industrial activities was designed and detailed neglecting the earthquake load or according to outdated seismic design criteria and regulations. Its seismic retrofit is a main challenge for the Engineering Community and a critical objective for institutional and private bodies. Among the envisaged solutions, the introduction of dissipative braces appears to be promising, although mostly inapplicable for these buildings, due to the brace lengths required by their typical large dimensions and the related proportioning against buckling. In this paper, an innovative seismic retrofitting technique based on monolateral dissipative bracing is investigated. The device proposed in this paper, yet in phase of preliminary design and testing, dissipates energy through friction in tension only while freely deforming in compression, which makes the issue related to compressive buckling irrelevant. A numerical analysis is carried out to investigate the efficiency of the proposed device in seismic retrofitting of precast industrial frame buildings with the aim to explore its feasibility and to better orient the definition of the slip threshold load range and the future development of the physical device. The simplified Capacity Spectrum Method (CSM) is employed for the global framing of the structural behaviour of the highly nonlinear retrofitted structures under seismic actions. A numerical tool is set to automatically apply the CSM based on the definition of few main parameters governing the seismic response of precast frame structures. The efficacy of the CSM is critically analysed through the comparison with the results of a set of nonlinear dynamic analyses. A smart simplified design process aimed at framing the most efficient threshold slip/yield load of the device given an existing structural configuration is presented with the application of the CSM through the identification of the most efficient performance indicator related to either displacement, shear force, equivalent dissipation of energy or a combination of them.
Technological troubleshooting based on sentence embedding with deep transformers
Authors: Alfeo Antonio L. , Cimino Mario G. C. A. , Vaglini Gigliola 
Published: June 2021

AbstractIn nowadays manufacturing, each technical assistance operation is digitally tracked. This results in a huge amount of textual data that can be exploited as a knowledge base to improve these operations. For instance, an ongoing problem can be addressed by retrieving potential solutions among the ones used to cope with similar problems during past operations. To be effective, most of the approaches for semantic textual similarity need to be supported by a structured semantic context (e.g. industry-specific ontology), resulting in high development and management costs. We overcome this limitation with a textual similarity approach featuring three functional modules. The data preparation module provides punctuation and stop-words removal, and word lemmatization. The pre-processed sentences undergo the sentence embedding module, based on Sentence-BERT (Bidirectional Encoder Representations from Transformers) and aimed at transforming the sentences into fixed-length vectors. Their cosine similarity is processed by the scoring module to match the expected similarity between the two original sentences. Finally, this similarity measure is employed to retrieve the most suitable recorded solutions for the ongoing problem. The effectiveness of the proposed approach is tested (i) against a state-of-the-art competitor and two well-known textual similarity approaches, and (ii) with two case studies, i.e. private company technical assistance reports and a benchmark dataset for semantic textual similarity. With respect to the state-of-the-art, the proposed approach results in comparable retrieval performance and significantly lower management cost: 30-min questionnaires are sufficient to obtain the semantic context knowledge to be injected into our textual search engine.
Study on operational space control of a redundant robot with un-actuated joints: experiments under actuation failure scenarios
Authors: Lee Yisoo , Tsagarakis Nikos , Lee Jinoh 
Published: June 2021

AbstractThis paper analyzes operational space dynamics for redundant robots with un-actuated joints and reveals their highly nonlinear dynamic impacts on operational space control (OSC) tasks. Unlike conventional OSC approaches that partly address the under-actuated system by introducing rigid grasping or contact constraints, we deal with the problem even without such physical constraints which have been overlooked, yet it includes a wide range of applications such as free-floating robots and manipulators with passive joints or unwanted actuation failure. In addition, as an intuitive application example of the drawn result, an OSC is formulated as an optimization problem to alleviate the dynamics disturbance stemmed from the un-actuated joints and to satisfy other inequality constraints. The dynamic analysis and the proposed control method are verified by a number of numerical simulations as well as physical experiments with a 7-degrees-of-freedom robotic arm. In particular, we consider joint actuation failure scenarios that can be occurred at certain joints of a torque-controlled robot and practical case studies are performed with an actual redundant robot arm.
Thomas Aquinas and Hervaeus Natalis on First and Second Intentionality
Authors: Amerini Fabrizio 
Published: June 2021

AbstractThomas Aquinas and Hervaeus Natalis (†1323) share a correlational theory of intentionality. When I cognize a thing, I am in a real relation with the thing cognized and at the same time the thing is in a relation of reason with me. Hervaeus coins the term “intentionality” to designate precisely this relation of reason. First and second intentionality express two stages of this relation. First intentionality refers to the relation that a thing has to the mind, while second intentionality indicates the relation that a thing qua cognized has to the mind. Thus, first intentionality involves direct cognition, while second intentionality reflexive cognition. This theory of intentionality has two purposes: first, to de-psychologize the cognitive process and second, to allow the application of Aristotle’s table of categories to the sphere of the mental. Through his detailed analysis of the relation of intentionality, Hervaeus clarifies some of Thomas’s obscurer points, but at the same time he has to solve a delicate problem of circularity entailed by the notion of intentionality as a relation of reason.
Is sewage sludge a valuable fertilizer? A soil microbiome and resistome study under field conditions
Authors: Markowicz Anna , Bondarczuk Kinga , Wiekiera Aleksandra , Sułowicz Sławomir 
Published: June 2021

Abstract
Purpose
Sewage sludge land application is strongly recommended to improve soil quality and fertility despite the presence of pollutants, pathogens and antibiotic resistance genes. This study aimed to assess the fertilization value of low and recommended by law sewage sludge dose (15 t ha−1).

Materials and methods
In a 540-day field study, the effect of sewage sludge on the soil physicochemical and microbial parameters, emphasising antibiotic and metal resistance spread, was investigated.

Results
In contrast to expectations, sewage sludge did not improve the organic matter, nutrient content and microbial activity in the soil; therefore, the fertilization effect was not achieved. Moreover, an increase in the bioavailable Cd, Ni and Cu content was observed. Canonical correspondence analysis revealed that these increases mainly explain the changes in the soil microbial community. Sixteen resistance genes and four integron classes were detected in both the total DNA and on plasmids isolated from sewage sludge. Obtained plasmids confer β-lactam resistance or extreme resistance to tetracycline (> 256 μg mL−1). Two antibiotic resistance genes (blaNPS-2, tetA) were transferred into the fertilized soil and detected up to 6 months after the fertilization.

Conclusion
Our results provide evidence that the regulated dose of sewage sludge, even when characterized by low total metal content, may affect soil microbial microbiome and resistome. Therefore, these findings provide critical data that have public health implications, which may raise concerns about the suitability of applying sewage sludge to the soil even at the low regulated dose.
Enhanced culturing techniques for the mycobiont isolated from the lichen Xanthoria parietina
Authors: Pichler Gregor , Candotto Carniel Fabio , Muggia Lucia , Holzinger Andreas , Tretiach Mauro , Kranner Ilse 
Published: June 2021

AbstractLichens and their isolated symbionts are potentially valuable resources for biotechnological approaches. Especially mycobiont cultures that produce secondary lichen products are receiving increasing attention, but lichen mycobionts are notoriously slow-growing organisms. Sufficient biomass production often represents a limiting factor for scientific and biotechnological investigations, requiring improvement of existing culturing techniques as well as methods for non-invasive assessment of growth. Here, the effects of pH and the supplement of growth media with either D-glucose or three different sugar alcohols that commonly occur in lichens, D-arabitol, D-mannitol and ribitol, on the growth of the axenically cultured mycobiont isolated from the lichen Xanthoria parietina were tested. Either D-glucose or different sugar alcohols were offered to the fungus at different concentrations, and cumulative growth and growth rates were assessed using two-dimensional image analysis over a period of 8 weeks. The mycobiont grew at a pH range from 4.0 to 7.0, whereas no growth was observed at higher pH values. Varying the carbon source in Lilly-Barnett medium (LBM) by replacing 1% D-glucose used in the originally described LBM by either 1%, 2% or 3% of D-mannitol, or 3% of D-glucose increased fungal biomass production by up to 26%, with an exponential growth phase between 2 and 6 weeks after inoculation. In summary, we present protocols for enhanced culture conditions and non-invasive assessment of growth of axenically cultured lichen mycobionts using image analysis, which may be useful for scientific and biotechnological approaches requiring cultured lichen mycobionts.