bluuebunny/crossref_metadata_2025_split huggingface dataset:
An education approach for the Anthropocene epoch
Authors: Souza Cristiane Mansur de Moraes 
Published: September 2021

It is now well established in the literature that there is a need to incorporate the concept of sustainability into education at all study levels. However, there is considerable uncertainty expressed concerning how it could best be achieved and how the resilience concept would enhance this idea. This article aims to address this gap. The objective is to explore aspects of socio-ecological resilience, that underlies a university case study. The methodology is exploratory, descriptive, and explanatory. Results demonstrate that civil engagement university activities are an education approach that provides students with experiences that build skills necessary for addressing the challenges of the Anthropocene Epoch. The conclusion of the article emphasizes that the education for the Anthropocene epoch should consider the enhancement of ecosystem services by demonstrating that humans are part of the social-ecological systems; considering interdisciplinarity as a methodological approach; demonstrating the variety of potentials on participation of stakeholders by civil engagement as developing autonomy both on students and stakeholders and developing the ability for proactive attitudes. Is also enhance learning and social learning by civil engagement and participation.
Currículo surdo: a luta contra a hegemonia ouvinte inclusiva
Authors: Vale Jackson da Silva , Costa Lucinete Gadelha da , Vale Debora Rocha de Souza 
Published: September 2021

O atual currículo escolar inclusivo permeia as escolas de ensino regular, o que propicia reflexões político-pedagógicas para discutir quanto ao universo educacional do Surdo, uma vez que a identidade linguística se diferencia da modalidade oral-auditiva. O nosso objetivo é abordar sobre o currículo escolar inclusivo para os Surdos, e discorrer sobre a luta da comunidade surda contra essa hegemonia curricular. Trata-se de um trabalho teórico, amparado a luz de autores e pesquisares que oportunizam a construção de conhecimentos, diálogos e críticas frente ao recorrente e atual modelo de ensino, ideologias e práticas ao alunado Surdo. Este trabalho surgiu através da disciplina “Concepções e Diretrizes Curriculares nas Ciências”, do curso de Mestrado Acadêmico em Educação em Ciências na Amazônia, da Universidade do Estado do Amazonas. Estudos que tratem sobre o currículo escolar inclusivo, e principalmente sobre entender quanto a especificidade educacional do sujeito Surdo, poderá contar com subsídios que colaboram para a desconstrução do atual modelo de educação inclusivo, propiciando assim, a construção para uma educação diferenciada e que realmente contemple a modalidade visual do alunado Surdo. Argumentamos que educação bilíngue e currículo Surdo é a modalidade de ensino necessária ao Surdo, pois volta-se para uma proposta que abraça as especificidades, cultura, língua e história do povo e da comunidade Surda, promovendo verdadeiramente o desenvolvimento de indivíduos cidadãos, oportunizando ainda o direito de realmente estar e fazer parte de um espaço em que o encontro com seus semelhantes e com uma comunidade construa identidades e consciência Surda.
A Review Predictive Mathematical Modeling of Alkali-Silica Reaction in Concrete: evolution, current understanding and the knowledge gaps
Authors: Revoredo Dhiego Henrique Ferreira , Nobrega Ana Cecília Vieira , Carneiro Arnaldo Manoel Pereira , Marciano João Emanuell Araújo 
Published: September 2021

Predictive mathematical models have been proposed in alkali-silica reaction (ASR). Predicting concrete degradation and its effects on mechanical properties is of interest given the long time until degradation becomes critical for intervention and recovery, and difficult structural access for predictive and corrective monitoring and treatment. The present paper presents a general overview of the evolution of the aforementioned predictive mathematical models, interrelating them to the maturation of the phenomenological state of the art associated with ASR. For this purpose, a systematic literature review was used, followed by bibliometric analysis and meta-analysis. In this study, 104 articles from 1974 to 2020 were selected, of which 31 articles were reviewed on the topic of mathematical modeling of ASR. The results of the method indicated the importance of the methodological approach of literature review to provide a comprehensive and chronological view of the evolution of ASR consolidated in the literature. It was found that the mathematical models have evolved considering the phenomenological approach of ASR.
Produção científica sobre mulheres com câncer de colo uterino em hemodiálise: estudo bibliométrico
Authors: Melo Edjane Marcia Linhares , Frazão Janice de Matos , Peixoto Ivonete Vieira Pereira , Valois Rubenilson Caldas 
Published: September 2021

Objetivou-se descrever o panorama da produção científica, encontrada na base de dados Web of Science, sobre mulheres com câncer de colo uterino em hemodiálise, entre os anos de 2017 a 2021. Trata-se de um estudo bibliométrico, de abordagem quantitativa. Os dados foram coletados na base de dados Web of Science, utilizando a estratégia de busca PiCo. Realizando como critério de inclusão: publicações disponíveis em periódicos científicos no período de 2017 a 2021; texto completo em inglês, português ou espanhol e termos de busca presentes no título ou resumo. Como critério de exclusão, eliminaram-se as publicações nas modalidades: tese, dissertação e monografia e artigos repetidos foram suprimidos. Foram encontrados 14 artigos, nos quais foram aplicadas as leis bibliométricas de Lotka, Zipf e Bradford. Apresentando pouca frequência de estudos a cerca desta temática, mesmo tendo grande representatividade epidemiológica e sendo a causa primária de morte por câncer na Região Norte do Brasil. Levando a observar uma lacuna em pesquisas mundiais, principalmente nacional. Remetendo a necessidade de estudos e pesquisas sobre as mulheres com câncer de colo uterino em hemodiálise.
Aspectos citológicos entre papanicolau e gravidez
Authors: Cabral Valéria Cláudia Pereira , Souza Belysa Sousa de , Martins Letícia Dias 
Published: September 2021

A saúde feminina é um processo multifatorial e de muitas fases. Uma das mais importantes e frequentes problemáticas é o câncer de colo de útero, que deve ser rastreado em todos os períodos, inclusive na gravidez. Objetivo: no geral, temos: abordar a importância do exame de Papanicolau em mulheres grávidas. Já os específicos são: descrever os tipos celulares vistos nos exames de PCCU durante a gravidez, relacionando com a ação hormonal desta fase e relacionar os achados de microrganismos mais comuns nos resultados de PCCU em grávidas. Metodologia: revisão bibliográfica sistemática, com um total de 39 materiais selecionados, dentre artigos científicos, manuais ou sites institucionais em pesquisa de câncer – a maioria obtidos por bases de dados científicas e compreendendo os últimos 3 anos completos, em português e inglês. Resultados e Discussão: Foram abordados os fatores que contribuem para as taxas de adesão ao exame e também se percebeu a importância e segurança do procedimento, independente do período gestacional. Conclusão: O Papanicolau é confiável em gestantes, sua realização estando intimamente relacionada com níveis de educação sexual e de acesso a serviços de saúde, podendo melhorar significativamente a saúde feminina no país.
Aktivitas Antijamur Ekstrak Biji Pepaya (Carica Papaya L.) Varietas Bangkok
Authors: Siagian Forman Erwin , Sabono Dena Carolina , Alfarabi Muhammad 
Published: September 2021

Abstrak
Candida sp. dan Cryptococcus sp. merupakan jamur oportunistik yang dapat menyebabkan penyakit pada manusia dan dapat berakibat fatal jika tidak ditangani dengan cepat dan tepat. Saat ini terdapat permasalahan yaitu resistensi antijamur dan jenis terapi terhadap jamur yang terbatas. Terdapatnya bahan alam yang melimpah di Indonesia menjadi suatu potensi untuk mengembangkan obat anti jamur baru yang memiliki efektivitas tinggi, efek samping yang minimal, dan murah. Salah satu bahan alam yang belum tereksplorasi untuk antijamur adalah biji pepaya varietas bangkok. Biji pepaya selama ini lebih banyak menjadi limbah organik. Oleh karena hal tersebut, tujuan dari penelitian ini adalah untuk menguji aktivitas antijamur dari ekstrak biji pepaya bangkok (Carica papaya L.). Jamur yang digunakan pada penelitian ini adalah Candida albicans dan Cryptococcus neoformans. Metode yang digunakan adalah perhitungan zona hambat pada sumur di cawan petri. Hasil penelitian menunjukkan bahwa tidak terdapat zona hambat pada media yang terdapat C. albicans dan C. neoformans. Dapat disimpulkan, ekstrak biji papaya tidak memiliki aktivitas antijamur terhadap kedua jamur tersebut.
Kata kunci: Pepaya bangkok, Antijamur, Bahan alam
Abstract
Candida sp. and Cryptococcus sp. are opportunistic fungi that can be fatal disease in humans if not treated properly. However, resistance of antifungal drugs have been emerged, therefore limit their benefit for therapy. Many natural products in Indonesia have potential to be established for new antifungal drugs that have high effectiveness, minimal side effects, and inexpensive. Papaya bangkok seed has not been explored for its antifungal activity. This seed become more organic waste. The aim of this study was to test antifungal activity of various papaya bangkok seed extract concentrations. We measured the inhibiton zone of papaya extract to Candida albicans and Cryptococcus neoformans. Result showed no inhibition zone for each seed extract concentrations. Papaya bangkok seed extract has not antifungal activity.
Keywords: Papaya bangkok, antifungal, natural product
Sexualidade e deficiência: reflexões a partir de um curta metragem
Authors: Zuin Luiz Fernando , Denari Fatima Elizabeth , Vicente Aparecido Renan 
Published: September 2021

A sexualidade ainda é um tema polêmico que desperta dificuldades í queles que cotidianamente se defrontam com essa questão, e a problemática pode ser ainda maior quando falamos da sexualidade de pessoas com deficiência, cuja exclusão afeta principalmente o campo sexual. O senso comum elenca o público com deficiência como assexuado, tornando-o excluí­do sexualmente. Frente ao exposto, a pesquisa tem como objetivo principal analisar as dificuldades enfrentadas no campo sexual por jovens com Sí­ndrome de Down a partir da análise do curta metragem Colegas, filme do diretor Marcelo Galvão lançado no ano de 2013. A metodologia utilizada foi a do método descritivo, considerando as cenas mais marcantes em comparativo com a realidade social. Os resultados apontam que é preciso, a partir de uma visão otimista, valorizar os aspectos positivos em detrimento dos preconceitos, dos mitos e tabus que abarcam a sexualidade da pessoa com Sí­ndrome de Down.Palavras- chave: Sexualidade, Estigma, Sí­ndrome de Down.
Uncovering the Association Between m5C Regulator-Mediated Methylation Modification Patterns and Tumour Microenvironment Infiltration Characteristics in Hepatocellular Carcinoma
Authors: Gu Xinyu , Zhou Haibo , Chu Qingfei , Zheng Qiuxian , Wang Jing , Zhu Haihong 
Published: September 2021

Background: 5-Methylcytosine (m5C) plays essential roles in hepatocellular carcinoma (HCC), but the association between m5C regulation and immune cell infiltration in HCC has not yet been clarified.Methods: In this study, we analysed 371 patients with HCC from The Cancer Genome Atlas (TCGA) database, and the expression of 13 m5C regulators was investigated. Additionally, gene set variation analysis (GSVA), unsupervised clustering analysis, single-sample gene set enrichment analysis (ssGSEA), correlation analysis, and immunohistochemical (IHC) staining were performed.Results: Among the 371 patients, 41 had mutations in m5C regulators, the frequency of which was 11.26%. Compared with normal hepatic tissues, the expression of m5C regulators with copy number variations (CNVs) expansion was significantly higher than that in HCC tissues. Then, we identified three m5C modification patterns that had obvious tumour microenvironment (TME) cell infiltration characteristics. The prognostic analysis of the three major m5C modification subtypes showed that Cluster-2 had a clear survival advantage over the others. In addition, we found that DNMT1 was highly expressed in tumour tissues compared with normal tissues in a tissue microarray (TMA) and that it was positively correlated with many TME-infiltrating immune cells. High expression of the m5C regulator DNMT1 was related to a poor prognosis in patients with HCC. Furthermore, we developed three distinct Immu-clusters. Importantly, mRNAs related to the transcription of growth factor β (TGF-β)/EMT pathway were significantly up-regulated in Immu-cluster 2, indicating that this cluster is considered to be the immune rejection phenotype. Immu-cluster 3 showed elevated expression of mRNAs related to immune checkpoint genes.Conclusion: Our work revealed the association between m5C modification and immune regulators in the TME. These findings also suggest that DNMT1 has great potential as a prognostic biomarker and therapeutic target for HCC.
Clinical Characteristics and Contemporary Prognosis of Ventricular Septal Rupture Complicating Acute Myocardial Infarction: A Single-Center Experience
Authors: Wang Lu , Xiao Li-Li , Liu Chao , Zhang Yan-Zhou , Zhao Xiao-Yan , Li Ling , Wang Xiao-Fang , Dong Jian-Zeng 
Published: September 2021

Objectives: Ventricular septal rupture (VSR) is a rare but lethal complication of acute myocardial infarction (AMI). We conducted a retrospective analysis of the clinical characteristics of VSR patients and explored the risk factors for long-term mortality.Methods: In this single-center cohort study, 127 patients diagnosed with post-AMI VSR between May 2012 and April 2019 were included. Demographic, clinical, operative, and outcome data were collected. The 30-day and long-term mortality were outcomes of interest. Cox proportional hazard regression analysis was used to explore the predictors of long-term mortality.Results: The mean age of the VSR cohort was 66.6 ± 8.7 years, 67 (52.8%) were males. Among the 127 patients, 78 patients (61.4%) were medically managed, 31 (24.4%) patients underwent percutaneous transcatheter closure (TCC), and 18 (14.2%) patients received surgical repair. The median follow-up time was 1129 days [interquartile range: 802–2019 days]. The 30-day mortality of the medically managed group, percutaneous TCC group, and surgical management group was 93.6, 22.6, and 11.1%, respectively; and the long-term mortality was 96.2, 25.8, and 22.2%, respectively. VSR repair treatment including surgical management (HR 0.01, 95% CI 0.001–0.09, p &lt; 0.001) and percutaneous TCC (HR 0.09, 95% CI 0.03–0.26, p &lt; 0.001) was associated with a better prognosis, and cardiogenic shock (CS) (HR 9.30, 95% CI 3.38–25.62, p &lt; 0.001) was an independent risk factor of long-term mortality.Conclusions: The prognosis of VSR patients without operative management remains poor, especially in those complicated with CS. Timely and improved surgery treatment is needed for better outcomes in VSR patients.
Signatures and Clinical Significance of Amino Acid Flux in Sarcopenia: A Systematic Review and Meta-Analysis
Authors: Dai Miao , Lin Taiping , Yue Jirong , Dai Lunzhi 
Published: September 2021

BackgroundDysregulation of amino acids is closely linked to the initiation and progression of sarcopenia. We summarized recent advancements in the studies of amino acid profiles in sarcopenia and systematically presented the clinical significance of amino acid flux in sarcopenia.MethodsWe systematically searched in MEDLINE, EMBASE, and Cochrane library from inception to June 1, 2021 to capture all studies examining metabolomics of sarcopenia. We used the following keywords: sarcopenia, metabonomics, metabolomics, amino acid profile, and mass spectrometry. Original articles comparing amino acid patterns between persons with and without sarcopenia were included. Two independent investigators independently completed title and abstract screening, data extraction, and quality evaluation. We used a random effects model to examine the association between amino acids levels and sarcopenia. Sensitivity analyses restricted the analyses to studies in which muscle mass was measured by bioelectrical impedance analysis. Study quality was evaluated according to the Agency for Healthcare Research and Quality (AHRQ) checklist.ResultsThe systematic research yielded six eligible articles, comprising 1,120 participants. Five studies used muscle mass in combination with physical performance and/or muscle strength as the criteria to diagnose sarcopenia, while one study used muscle mass as a diagnostic criterion alone. We found that the concentrations of branched-chain amino acids leucine (standardized mean difference [SMD] -1.249; 95% confidence interval [CI]: -2.275, -0.223, P = 0.02, I2 = 97.7%), isoleucine (SMD -1.077; 95% CI: -2.106, -0.049, P = 0.04, I2 = 97.8%), and aromatic amino acid tryptophan (SMD -0.923; 95% CI: -1.580, -0.265, P = 0.01, I2 = 89.9%) were significantly reduced in individuals with sarcopenia. Study results were robust in sensitivity analysis.ConclusionsThe homeostasis of amino acids is critical to maintaining muscle health. The profiles of amino acids might be useful biomarkers for the characterization of sarcopenia. Future studies are warranted to study the clinical significance of amino acids in the diagnosis and treatment of sarcopenia.
The Effect of Yoga Meditation Practice on Young Adults’ Inhibitory Control: An fNIRS Study
Authors: Jiang Dongdong , Liu Zongyu , Sun Guoxiao 
Published: September 2021

Objectives: The present study aimed to test the effect of yoga meditation (YoMed) practice on inhibitory control of young adults.Methods: A total of 50 participants (23 male, 21–28 years old) from a university in Jinan, Shandong Province were enrolled in this study. Participants were randomly assigned to a YoMed group or a Control group. Participants’ basic information, physical activity, and inhibitory control were measured. A multi-channel continuous-wave near-infrared spectrometer was used to monitor the brain’s hemodynamic responses.Results: After the intervention, we found significant differences in Flanker tasks between the YoMed group and Control group. The accuracy in the YoMed group was higher than those in the Control group (p &lt; 0.05). Analysis of fNIRS data showed that oxyhemoglobin (oxy-Hb) levels in the prefrontal cortex (PFC) increased in the YoMed group during the Flanker tasks after the YoMed intervention.Conclusion: YoMed has a temporarily promoting effect on the brain activation of young adults. It is an effective and appropriate exercise to improve the inhibitory control of young adults.
Multicentre Comparison of the Toxicity and Effectiveness of Lobaplatin-Based Versus Cisplatin-Based Adjuvant Chemotherapy in Oesophageal Carcinoma
Authors: Zheng Yan , Li Yin , Liu Xianben , Sun Haibo , Liang Guanghui , Hu Jiajia , Li Liping , Xing Wenqun 
Published: September 2021

ObjectivesLobaplatin (LBP), a third-generation cisplatin derivative has shown promising activity and few side effects in oesophageal squamous cell carcinoma (ESCC) in previous reports. We compared LBP plus docetaxel with cisplatin plus docetaxel as adjuvant chemotherapy in ESCC patients to determine the effects on overall survival (OS) and toxicity.MethodsA multicentre retrospective study was performed using propensity score matching (PSM) with the Medicine-LinkDoc database. Patients diagnosed with stage II-III ESCC treated with adjuvant chemotherapy (cisplatin plus docetaxel or LBP plus docetaxel) between January 2013 and December 2016 were selected from 6 centres in China.ResultsThere were 733 eligible ESCC patients. After PSM (1:1 ratio), 458 patients remained. The 5-year OS rates of the cisplatin and LBP groups were 25.9% and 23.6%, respectively (P=0.457). Leukopenia (grade III-IV/I-II/0: 2.62%/34.5%/59.39% versus 5.24%/43.23%/45.85%; P=0.0176), neutropenia (grade III-IV/I-II/0: 6.55%/37.56%/51.09% versus 4.37%/53.28%/36.34%; P=0.0015), nephrotoxicity (grade I-II/0: 13.97%/76.86% versus 26.64%/65.94%; P&lt;0.001) and gastrointestinal symptoms (grade III-IV/I-II/0: 2.18%/54.59%/32.31% versus 6.55%/65.07%/20.88%; P=0.0011) were more frequent in the cisplatin group.ConclusionsCompared with cisplatin plus docetaxel, LBP plus docetaxel provided the same survival benefits but lower side effects of myelosuppression and gastrointestinal symptoms. LBP plus docetaxel might be a choice for adjuvant chemotherapy in ESCC.Clinical Trial RegistrationLobaplatin or Cisplatin in Adjuvant Chemotherapy for Oesophageal Carcinoma, identifier NCT03413436.
Molecular Alterations in Lung Adenocarcinoma With Ground-Glass Nodules: A Systematic Review and Meta-Analysis
Authors: Wei Zihan , Wang Ziyang , Nie Yuntao , Zhang Kai , Shen Haifeng , Wang Xin , Wu Manqi , Yang Fan , Chen Kezhong 
Published: September 2021

Background and AimsNodular ground-glass lesions have become increasingly common with the increased use of computed tomography (CT), while the genomic features of ground-glass opacities (GGOs) remain unclear. This study aims to comprehensively investigate the molecular alterations of GGOs and their correlation with radiological progression.MethodsStudies from PubMed, Embase, Cochrane Library, and Web of Science, using PCR, targeted panel sequencing, whole exosome sequencing, and immunohistochemistry, and reporting genomic alterations or PD-L1 expressions in lung nodules presenting as GGOs until January 21, 2021 were included in this study. Chi-square test, random-effects model, and Z-test analysis were adopted to analyze the data.ResultsA total of 22 studies describing mutations in lung adenocarcinoma (LUAD) with GGOs were analyzed. EGFR was the most frequently mutative gene (51%, 95%CI 47%–56%), followed by TP53 (18%, 95%CI 6%–31%), HER2 (10%, 95%CI 0%–21%), ROS1 (6%, 95%CI 0%–18%), and KRAS (6%, 95%CI 3%–9%). The correlation between the frequency of EGFR mutation and radiological was observed and the differences were found to be not statistically significant in the subgroups, which are listed as below: radiological: gGGO 47.40%, 95%CI [38.48%; 56.40%]; sGGO 51.94%, 95%CI [45.15%; 58.69%]. The differences of the frequency of KRAS mutation in the different subgroups were also consistent with this conclusion, which are listed as: radiological gGGO 3.42, 95%CI [1.35%; 6.13%]; sGGO 12.27%, 95%CI [3.89%; 23.96%]. The pooled estimated rate of PD-L1 was 8.82%, 95%CI [5.20%–13.23%]. A total of 11.54% (3/26) of the SMGGNs were confirmed to be intrapulmonary spread by WES.ConclusionsSomatic genetic alterations are considered in early-stage GGO patients without distinct changes of the frequency following the progress of the tumor. This review sheds insight on molecular alterations in LUAD with GGOs.