bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of Response to Radiosurgery and Immunotherapy in Brain Metastases: Quo Vadis?
Authors: Galldiks Norbert , Werner Jan-Michael , Lohmann Philipp , Kocher Martin , Fink Gereon R. , Langen Karl-Josef 
Published: February 2021

Abstract
Purpose of Review
This review presents an overview of how advanced imaging techniques may help to overcome shortcomings of anatomical MRI for response assessment in patients with brain metastases who are undergoing stereotactic radiosurgery, immunotherapy, or combinations thereof.

Recent Findings
Study results suggest that parameters derived from amino acid PET, diffusion- and perfusion-weighted MRI, MR spectroscopy, and newer MRI methods are particularly helpful for the evaluation of the response to radiosurgery or checkpoint inhibitor immunotherapy and provide valuable information for the differentiation of radiotherapy-induced changes such as radiation necrosis from brain metastases. The evaluation of these imaging modalities is also of great interest in the light of emerging high-throughput analysis methods such as radiomics, which allow the acquisition of additional data at a low cost.

Summary
Preliminary results are promising and should be further evaluated. Shortcomings are different levels of PET and MRI standardization, the number of patients enrolled in studies, and the monocentric and retrospective character of most studies.
Spatial links in the analysis of voter turnout in European Parliamentary elections
Authors: Fiorino Nadia , Pontarollo Nicola , Ricciuti Roberto 
Published: February 2021

AbstractThis paper investigates the turnout in European Parliamentary elections by analyzing the four EP elections from 1999 to 2014 in 155 regions in EU-12. We use a number of econometric techniques that account for spatial dependence, also dealing with heteroskedasticity and endogeneity. The results confirm the role of spatial spillovers and indicate a significant role for GDP per capita, unemployment, age, institutional and electoral variables in influencing turnout. Finally, we disentangle the direct and indirect effects of the regional variable in affecting turnout.
Impact of inter-particle collision on elbow erosion based on DSMC-CFD method
Authors: Sun Xiao-Yang , Cao Xue-Wen 
Published: February 2021

AbstractIn this work, computational fluid dynamics (CFD) is used to study elbow erosion due to a gas–solid two-phase flow. In particular, the direct simulation Monte Carlo (DSMC) method is used to study the impact of inter-particle collision on the erosion behavior. The two-way coupled Euler–Lagrange method is used to solve the gas–solid flow, and the DSMC method is used to consider the collision behavior between particles. The effects of key factors, such as the particle concentration distribution and inter-particle collision, on the erosion ratio are evaluated and discussed. The effectiveness of the method is verified from experimental data. The results show that the inter-particle collision significantly influences the particle movement path and erosion ratio. When the inter-particle collision is considered, the maximum erosion position is offset. The erosion model proposed by Oka et al., who used the DSMC method, agrees best with the experimental data, and the average percentage error decreases from 39.2 to 27.4%.
Repeated historical earthquakes in Sousse, Monastir and El-Jem (Tunisia)—an archaeoseismological study
Authors: Kázmér Miklós 
Published: February 2021

AbstractTunisia is known of sparse and moderate earthquakes. However, there are seismically damaged historical buildings in the eastern Sahel region. The Roman amphitheatre of Thysdrus (modern El-Jem), various Islamic religious and secular buildings in Sousse and Monastir testify to seismic events with intensity up to IX (EMS98 scale). We raise the hypothesis that their destruction was caused by the nearby east-west Cherichira-Abaieh Fault and the north-south Monastir Fault. Simultaneity of the 859 AD Kairouan earthquake and extensive restoration works in Sousse 50 km to the east allow assessing magnitude up to 7.2 based on segment length. The city was hit both by the 859 AD and a post-1575 earthquake. Being nearby two active faults, seismic hazard in Sousse is higher than either in Kairouan or in Monastir.
Using Principal Paths to Walk Through Music and Visual Art Style Spaces Induced by Convolutional Neural Networks
Authors: Gardini E. , Ferrarotti M. J. , Cavalli A. , Decherchi S. 
Published: February 2021

AbstractComputational intelligence, particularly deep learning, offers powerful tools for discriminating and generating samples such as images. Deep learning methods have been used in different artistic contexts for neural style transfer, artistic style recognition, and musical genre recognition. Using a constrained manifold analysis protocol, we discuss to what extent spaces induced by deep-learning convolutional neural networks can capture historical/stylistic progressions in music and visual art. We use a path-finding algorithm, called principal path, to move from one point to another. We apply it to the vector space induced by convolutional neural networks. We perform experiments with visual artworks and songs, considering a subset of classes. Within this simplified scenario, we recover a reasonable historical/stylistic progression in several cases. We use the principal path algorithm to conduct an evolutionary analysis of vector spaces induced by convolutional neural networks. We perform several experiments in the visual art and music spaces. The principal path algorithm finds reasonable connections between visual artworks and songs from different styles/genres with respect to the historical evolution when a subset of classes is considered. This approach could be used in many areas to extract evolutionary information from an arbitrary high-dimensional space and deliver interesting cognitive insights.
Physicochemical evolution and evaluation of groundwater quality in Mougheul area (Southwest of Algeria)
Authors: Mebarki Saliha , Kharroubi Benali , Kendouci Mohammed Amin 
Published: February 2021

AbstractIn arid areas, the pressure on water resources and in particular on groundwater resources is on the rise, mainly due to increasing demand and the deterioration of water quality. In this context, the present work aims to follow the annual evolution, between 2009 and 2019 of the physicochemical parameters, and to evaluate the quality of groundwater of the region of Mougheul, by determining the data of pH, TDS, conductivity and the concentrations of major ions ( Ca+2, Mg+2, Na+, K+, Cl−, HCO3−, SO4−2, NO3−) of 07 water points. The results revealed that all the levels of the physicochemical parameters do not exceed the WHO potability standards, except high values were observed at the level of well W6 which exceeds the limits recommended by the WHO (50 mg /l). The diagram of Schöeller and Berkaloff shows that the groundwater has the bicarbonate magnesium facies. The representation of the data on the Piper triangular diagram shows that W6 has the facies chlorinated and calcium sulfate and magnesium and the other water points have the facies bicarbonate calcium and magnesium. SAR values show that the groundwater of Mougheul is excellent for irrigation. The classification according to the Wilcox diagram shows that the groundwater of Mougheul in general is good quality, but the well of W6 water is suitable for irrigation and requires monitoring the evolution of salinity.
RepID-deficient cancer cells are sensitized to a drug targeting p97/VCP segregase
Authors: Jang Sang-Min , Redon Christophe E. , Fu Haiqing , Indig Fred E. , Aladjem Mirit I. 
Published: February 2021

Abstract
Background
The p97/valosin-containing protein (VCP) complex is a crucial factor for the segregation of ubiquitinated proteins in the DNA damage response and repair pathway.

Objective
We investigated whether blocking the p97/VCP function can inhibit the proliferation of RepID-deficient cancer cells using immunofluorescence, clonogenic survival assay, fluorescence-activated cell sorting, and immunoblotting.

Result
p97/VCP was recruited to chromatin and colocalized with DNA double-strand breaks in RepID-deficient cancer cells that undergo spontaneous DNA damage. Inhibition of p97/VCP induced death of RepID-depleted cancer cells. This study highlights the potential of targeting p97/VCP complex as an anticancer therapeutic approach.

Conclusion
Our results show that RepID is required to prevent excessive DNA damage at the endogenous levels. Localization of p97/VCP to DSB sites was induced based on spontaneous DNA damage in RepID-depleted cancer cells. Anticancer drugs targeting p97/VCP may be highly potent in RepID-deficient cells. Therefore, we suggest that p97/VCP inhibitors synergize with RepID depletion to kill cancer cells.
Collision Every Night: Treating Nightmares with Trauma-focused Methods: Case Report
Authors: Szabó József , Tóth Szilvia 
Published: February 2021

Abstract
Introduction
We would like to present the case of a young patient with acute stress disorder and recurrent nightmares following the psychological trauma caused by a severe road traffic accident. The comprehensive therapy carried out at the Department of Traumatology included medication, trauma processing and a psychological method whose aim is to cease the development of nightmares.

Case Presentation
Psychiatric assessment and treatment was asked for a polytraumatised female patient at the Intensive Care Unit after she had undergone a neurosurgical intervention. Her medicinal treatment was continued at the Department of Traumatology. Besides the antidepressant venlafaxine she was treated in accordance with the EMDR protocol for acute stress disorder, and we also applied imagery rescripting to prevent her from having recurrent (daily) nightmares. As a result of the therapy, her symptoms were fast relieved, the nightmares stopped almost instantly, her mood improved, rumination and anxiety decreased significantly.

Conclusions
In view of the fast and significant symptomatic improvement, we can expect that the EMDR therapy and its protocol for acute stress disorder have successfully reactivated information processing, and besides the subjective relief we have managed to prevent a mental crisis that could lead to a suicide risk as well as the development of post-traumatic stress disorder. We also hope that the improvement will be long-lasting.
Assessment of groundwater quality for drinking and irrigation purpose using hydrochemical studies in Dera Bassi town and its surrounding agricultural area of Dera Bassi Tehsil of Punjab, India
Authors: Sharma Nitish , Vaid Upma , Sharma Sanjay Kumar 
Published: February 2021

AbstractPresent research aims to assess the suitability of groundwater of Dera Bassi town (Punjab) and its surrounding agricultural area for drinking as well as irrigation purpose. Thirty groundwater samples were collected (in February 2020) and analyzed for various physicochemical parameters. Results of physicochemical analysis were compared with Indian (IS 10500:2012) as well as WHO (2006) standards to ascertain the suitability of the groundwater samples for drinking purpose, and it has been found that results for almost all the parameters except alkalinity (at few sites) are within the permissible limit. The pattern of ionic dominance was observed in the order of Ca2+ > Mg2+ > Na+ > K+ for cations and Cl− > NO3− > SO42− > F− for anions. Further, according to the observed Kelly’s ratio, sodium adsorption ratio, sodium percentage, corrosivity ratio and permeability index, the groundwater samples were found to be fit for irrigation purpose. However, the magnesium ratio and residual sodium carbonate revealed that groundwater of the area under study is not fit for irrigation purpose at some sites. The plot of SAR values versus EC values in the US Salinity Laboratory diagram revealed that the majority of the samples fall under water type C3-S1 (high salinity—low SAR) and 36.77% samples fall under water type C2-S1 (medium salinity—low SAR). Gibb’s diagram revealed that all samples fall under rock dominance category. The values of index of base exchange (CAI 1 and CAI 2) indicate that both direct ion and reverse ion exchange processes are taking place in the region.
From antibodies to living drugs: Quo vadis cancer immunotherapy?
Authors: Szöőr Árpád , Szöllősi János , Vereb György 
Published: February 2021

AbstractIn the last few decades, monoclonal antibodies targeting various receptors and ligands have shown significant advance in cancer therapy. However, still a great percentage of patients experiences tumor relapse despite persistent antigen expression. Immune cell therapy with adoptively transferred modified T cells that express chimeric antigen receptors (CAR) is an engaging option to improve disease outcome. Designer T cells have been applied with remarkable success in the treatment for acute B cell leukemias, yielding unprecedented antitumor activity and significantly improved overall survival. Relying on the success of CAR T cells in leukemias, solid tumors are now emerging potential targets; however, their complexity represents a significant challenge. In preclinical models, CAR T cells recognized and efficiently killed the wide spectrum of tumor xenografts; however, in human clinical trials, limited antitumor efficacy and serious side effects, including cytokine release syndrome, have emerged as potential limitations. The next decade will be an exciting time to further optimize this novel cellular therapeutics to improve effector functions and, at the same time, keep adverse events in check. Moreover, we need to establish whether gene-modified T cells which are yet exclusively used for cancer patients could also be successful in the treatment for other diseases. Here, we provide a concise overview about the transition from monoclonal antibodies to the generation of chimeric antigen receptor T cells. We summarize lessons learned from preclinical models, including our own HER2-positive tumor models, as well as from clinical trials worldwide. We also discuss the challenges we are facing today and outline future prospects.
Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer
Authors: Komoto Tatiana Takahasi , Lee Jaehak , Lertpatipanpong Pattawika , Ryu Junsun , Marins Mozart , Fachin Ana Lúcia , Baek Seung Joon 
Published: February 2021

AbstractDespite intensive research efforts in recent decades, cancer remains a leading cause of death worldwide. The chalcone family is a promising group of phytochemicals for therapeutic use against cancer development. Naturally-occurring chalcones, as well as synthetic chalcone analogues, have shown many beneficial biological properties, including anti-inflammatory, antioxidant, and anti-cancer activities. In this report, trans-chalcone (TChal) was found to increase cell death in breast cancer cells, assessed using high content screening. Subsequently, using antibody array analysis, TChal was found to increase heme oxygenase-1 (HO-1) expression in TChal-treated breast cancer cells. Blocking of HO-1 by siRNA in breast cancer cells diminished the effect of TChal on cell growth inhibition. TChal-fed mice also showed less tumor growth compared to vehicle-fed mice. Overall, we found that TChal increases HO-1 expression in breast cancer cells, thereby enhancing anti-tumorigenesis. Our results suggest that HO-1 expression could be a potential new target of TChal for anti-tumorigenesis in breast cancer.
Mapping value sensitive design onto AI for social good principles
Authors: Umbrello Steven , van de Poel Ibo 
Published: February 2021

AbstractValue sensitive design (VSD) is an established method for integrating values into technical design. It has been applied to different technologies and, more recently, to artificial intelligence (AI). We argue that AI poses a number of challenges specific to VSD that require a somewhat modified VSD approach. Machine learning (ML), in particular, poses two challenges. First, humans may not understand how an AI system learns certain things. This requires paying attention to values such as transparency, explicability, and accountability. Second, ML may lead to AI systems adapting in ways that ‘disembody’ the values embedded in them. To address this, we propose a threefold modified VSD approach: (1) integrating a known set of VSD principles (AI4SG) as design norms from which more specific design requirements can be derived; (2) distinguishing between values that are promoted and respected by the design to ensure outcomes that not only do no harm but also contribute to good, and (3) extending the VSD process to encompass the whole life cycle of an AI technology to monitor unintended value consequences and redesign as needed. We illustrate our VSD for AI approach with an example use case of a SARS-CoV-2 contact tracing app.
Targeting of proteins to the cell wall of the diatom Thalassiosira pseudonana
Authors: Fattorini Neri , Maier Uwe G. 
Published: February 2021

AbstractDiatoms are unicellular phototrophic organisms with huge ecological impact. Characteristic for these organisms is their peculiar cell wall, which is composed of inorganic and organic components. Cell wall formation is a highly complex and orchestrated process, and in the last years has been studied intensively, also on the molecular level. Here, we review on the cell wall proteins of diatoms, with a focus on the species Thalassiosira pseudonana. We report on the expression patterns of these proteins in synchronized cultures, as well as their modifications and intracellular targeting.
Thermal controls on ice stream shear margins
Authors: Hunter Pierce , Meyer Colin , Minchew Brent , Haseloff Marianne , Rempel Alan 
Published: February 2021

AbstractIce stream discharge responds to a balance between gravity, basal friction and lateral drag. Appreciable viscous heating occurs in shear margins between ice streams and adjacent slow-moving ice ridges, altering the temperature-dependent viscosity distribution that connects lateral drag to marginal strain rates and ice stream velocity. Warmer ice deforms more easily and accommodates faster flow, whereas cold ice supplied from ice ridges drives advective cooling that counteracts viscous heating. Here, we present a two-dimensional (three velocity component), steady-state model designed to explore the thermal controls on ice stream shear margins. We validate our treatment through comparison with observed velocities for Bindschadler Ice Stream and verify that calculated temperatures are consistent with results from previous studies. Sweeping through a parameter range that encompasses conditions representative of ice streams in Antarctica, we show that modeled steady-state velocity has a modest response to different choices in forcing up until temperate zones develop in the shear margins. When temperate zones are present, velocity is much more sensitive to changes in forcing. We identify key scalings for the emergence of temperate conditions in our idealized treatment that can be used to identify where thermo-mechanical feedbacks influence the evolution of the ice sheet.
MALTSEV CONDITIONS FOR GENERAL CONGRUENCE MEET-SEMIDISTRIBUTIVE ALGEBRAS
Authors: OLŠÁK MIROSLAV 
Published: February 2021

AbstractMeet semidistributive varieties are in a sense the last of the most important classes in universal algebra for which it is unknown whether it can be characterized by a strong Maltsev condition. We present a new, relatively simple Maltsev condition characterizing the meet-semidistributive varieties, and provide a candidate for a strong Maltsev condition.
CHARACTERIZING EXISTENCE OF A MEASURABLE CARDINAL VIA MODAL LOGIC
Authors: BEZHANISHVILI GURAM , BEZHANISHVILI NICK , LUCERO-BRYAN JOEL , MILL JAN VAN 
Published: February 2021

AbstractWe prove that the existence of a measurable cardinal is equivalent to the existence of a normal space whose modal logic coincides with the modal logic of the Kripke frame isomorphic to the powerset of a two element set.
Quantitative assessment of the oxygen isotope composition of fish otoliths from Lake Mungo, Australia
Authors: Long Kelsie , Heslop David , Rohling Eelco J. 
Published: February 2021

AbstractThe Willandra Lakes region is a series of once interconnected and now-dry lake basins in the arid zone of southeastern Australia. It is a UNESCO World Heritage Site of cultural, archaeological, and geological significance, preserving records of Aboriginal occupation and environmental change stretching back to at least 50 ka. Linking the archaeology with the commensurate palaeoenvironmental information is complicated by the millennial time spans represented by the past hydrological record preserved in the sediment vs. the subdecadal evidence of each archaeological site. Oxygen isotope records across annual growth rings of fish otoliths (ear stones) can elucidate flooding and drying regimes on subannual scales. Otoliths from hearth sites (fireplaces) link lake hydrology with people eating fish on the lakeshore. Oxygen isotopic trends in hearth otoliths from the last glacial maximum (LGM) were previously interpreted in terms of high evaporation under dry conditions. However, this ignored hydrology-driven changes in water δ18O. Here, a mass balance model is constructed to test the effect lake desiccation has on water δ18O and how this compares with the LGM otolith records. Based on this modelling, we suggest that Lake Mungo otolith signatures are better explained by evaporation acting on full lakes rather than by lake drying.
Adipose tissue fatty acids suggest spatial and temporal dietary differences in great cormorants of the Baltic Sea area
Authors: Tverin Malin , Granroth Janne , Abrahamsson Alexander , Tang Patrik , Pihlström Henry , Lundström Karl , Käkelä Reijo 
Published: February 2021

AbstractIncreased numbers of great cormorants (Phalacrocorax carbo) in the Baltic Sea may have local impacts on fisheries and salmonid hatcheries. We studied spatial and temporal variability in cormorant diet, and potential consumption of hatchery salmonids, by analysing knee subcutaneous adipose tissue fatty acids (FA) of specimens (N = 77) collected along Swedish and Finnish coasts in different seasons during 2013–2017. The FA profiles of the subspeciessinensisandcarbowere similar, with large individual variation. The proportion of C18 polyunsaturated FAs (PUFAs) was the largest in the north, whereas the proportion of C20–22 monounsaturated FAs (MUFAs) increased towards the south, reflecting diminishing freshwater and increasing marine food web characteristics towards the south. As an exception, the C20–22 MUFA percentage was high insinensiscollected in June 2017 from the northern Baltic Sea. The source of C20–22 MUFAs was probably hatchery salmonids, raised on ocean fish hatchery feed and released 10 days before, near the cormorant capture site. The FA profiles of northern and southern cormorants differed from each other both in early and late summer samples, suggesting spatially different diets. The largest individual variation was found in 22:1n-11, characteristic of ocean zooplanktivorous fish, and likely originating from Atlantic wild or Baltic Sea hatchery-reared fish. This study shows that adipose tissue FA profiles can be used as proxies for seabird diet monitoring and indicators of predation on hatchery-reared fish. Obtaining quantitative estimates on the proportions of dietary fish species requires future feeding experiments, allowing calibration between the FA compositions and diet.