bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous twin anemia‐polycythemia sequence from two donors to one recipient in a monochorionic triamniotic pregnancy: Case report and review of the literature
Authors: Pena Burgos Eva Manuela , Regojo Zapata Rita María , Turiel Miranda Miriam , Antolín Alvarado Eugenia , De la Calle María 
Published: October 2021

AbstractMonochorionic triamniotic (MCTA) pregnancies present a high number of complications, mainly due to the presence of unbalanced vascular anastomoses, such as twin anemia‐polycythemia sequence (TAPS). Previous reported cases related to TAPS are in twin pregnancies or only affect the monochorionic component of dichorionic triamniotic (DCTA) pregnancies. We report an exceptional case, the only one reported as far as we know, of a MCTA pregnancy that developed a TAPS in which the three triplets are implicated, from two donors to one recipient. The pregnancy had been previously sonographically diagnosed as DCTA pregnancy and this could not explain the clinical results. The pathological study of the placenta showed the presence of three monochorionic dividing membranes, a congested area in the recipient parenchyma and two non‐congested areas in the donor's parenchyma that confirmed the clinical findings. Pathological study of multiple placentas should always be done because it provides understanding of pregnancy complications.
Beyond Co‐Location: Development of a School Health Integration Measure*
Authors: Ferenchak Kenny S. , Trieu Sang Leng , Franco Rosina , Jackson Nicholas J. , Dudovitz Rebecca 
Published: October 2021

ABSTRACTBACKGROUNDSchool‐based health centers (SBHCs) can integrate health and educational services to achieve common goals of student wellness and success. As no method exists to quantify the degree of integration for clinics and partner schools, this study aimed to design such a measure.METHODSMeasure items were drafted from the literature. Eleven school health experts from Los Angeles, CA, used a modified Delphi method to reach consensus around items for inclusion in a School Health Integration Measure (SHIM), evaluating each on its appropriateness, substantivity, and feasibility. Twenty‐eight staff at 17 SBHC campuses pilot tested the SHIM to examine its psychometric properties.RESULTSFrom 36 items, the expert panel utilized 4 rounds to reach consensus on 12 items across 5 domains: health authority, integrated programming, marketing and recruitment, shared outcomes, and staff collaboration. In the SHIM pilot, scores ranged from 2.25 to 5 (possible 1‐5, mean 3.53). The measure had high internal consistency (alpha = 0.9385) and was associated with participants' general assessment of integration at their sites (p = .001).CONCLUSIONSThe SHIM provides a new tool to quantify health and educational service integration at SBHC sites, drive practice improvement, and test whether integration leads to better student outcomes.
Temporary jobs and increasing inequality for recent cohorts in Italy
Authors: Tomelleri Alessio 
Published: October 2021

AbstractUsing tax‐based longitudinal microdata from 1985 to 2016, I document how the widening income distribution in Italy is driven by younger cohorts. Entry wages started to decrease around the mid‐1990s, at the same time returns to experience of new entrants in the labour market declined. Falling wage growth is linked to the institutional changes that occurred in the Italian labour market in the decade across the 2000s. I examine the impact of Italian labour market reforms on cohort‐specific wage inequality by looking at the relationship between the number of temporary job spells and individual earnings. Results confirm that young and high‐skilled new entrants show higher wage differential in comparison to older workers and that the increase in temporary jobs is a crucial factor in explaining the cohort wage gap.
Environmental influences on the cyanobacterial mat formation in the mangrove ecosystems along the southwest coast of India
Authors: Benny Niya , Thomas Lathika Cicily , Padmakumar Kunnatholickal Balakrishnan 
Published: October 2021

AbstractMangrove forests are highly diverse niches playing fundamental roles in ecosystem sustainability, particularly in the tropics. Benthic realms in mangrove forest sustain a wide variety of autotrophs among which cyanobacteria forms a major component. The present study discusses the spatiotemporal variabilities in benthic cyanobacterial assemblage in selected mangrove ecosystems (Kannur—S1, Kochi—S2 and Kollam—S3 were sampled for 1 year, 2018 to 2019) along the south‐west coast of India. A total of nine cyanobacterial species belonging to six genera were identified, which included mainly non‐heterocystous forms like Oscillatoria irrigua, Phormidium chalybeum, Geitlerinema bigranulatum, Oscillatoria sancta, Spirulina major, Trichodesmium sp., whereas heterocystous cyanobacteria included Nostoc sp. Oscillatoria irrigua was the major species distributed in all the mangrove ecosystems. Temporal variations were observed in the distribution with pre‐monsoon (PRM) and monsoon (MON) seasons having higher numerical density and lesser diversity of benthic cyanophytes with lesser abundance and comparatively higher diversity during post‐monsoon (POM). Regionally, S2 observed higher numerical abundance with higher dominance, whereas S3 observed less abundance with high diversity. Physico‐chemical parameters of sediment and pore water analysis observed that sediment temperature positively correlated with cyanobacterial abundance, whereas a negative correlation was observed with dissolved oxygen and pore water dissolved nitrate. Pore water salinity also influenced the community composition of cyanobacteria with heterocystous cyanobacteria in comparatively less saline conditions. Hence, the study emphasis spatiotemporal variabilities in the benthic cyanobacterial assemblage of mangrove ecosystems in relation to environmental variables.
Parathyroidectomy is associated with slow progression of vascular calcification in maintenance haemodialysis patients: A propensity score‐matched case–control study
Authors: Saeseow Sarunya , Vantanasiri Kornpong , Suvikapakornkul Ronnarat , Sukarayothin Thongchai , Apirakkittikul Navarat , Disthabanchong Sinee 
Published: October 2021

AbstractParathyroidectomy has been the mainstay of treatment of severe hyperparathyroidism in patients with kidney failure until the introduction of calcimimetic. Several large observational studies demonstrated the improvement in patient outcomes after parathyroidectomy. The benefit of parathyroidectomy on vascular calcification remains largely unexplored.AimTo examine the association between parathyroidectomy and the progression of vascular calcification as well as overall survival in maintenance haemodialysis patients.MethodThis is a matched case–control study undertaken between 2012 and 2020. Patients who underwent parathyroidectomy were identified and matched 1:1 to non‐parathyroidectomized (non‐PTX) haemodialysis patients using propensity score matching method resulting in 120 patients in each arm. Aortic arch calcification (AoAC) score was determined annually in the posteroanterior chest x‐ray. The average follow‐up period was 38 months.ResultsBaseline demographic, laboratory data and AoAC score were comparable among the two groups of patients. The prevalence of AoAC was 59% in the PTX group and 54% in the non‐PTX group (p = .43). Progression of AoAC occurred in 33% in the PTX group and 47% in the non‐PTX group (p = .04). Multivariate generalized linear model revealed parathyroidectomy as an independent protective factor [β (95% CI) −1.04 (−1.68, −0.41)] and increased serum calcium as a potentiating factor [β (95% CI) 0.62 (0.25, 0.1)] for progression of AoAC. Linear mixed models revealed an increase in AoAC score in both groups but between group comparisons indicated substantially slower progression in the PTX group. Rapid progression of AoAC was also observed more frequently among non‐PTX patients. Death occurred in 7 and 16% in the PTX and non‐PTX groups, respectively. Kaplan–Meier survival curve revealed better survival associated with parathyroidectomy (p = .01). More rapid progression of AoAC also correlated with worse survival.ConclusionParathyroidectomy was associated with slow progression of vascular calcification in maintenance haemodialysis patients.
The lived experience of severe maternal morbidity among Black women
Authors: Canty Lucinda 
Published: October 2021

AbstractBlack women are 3–4 times more likely to die from a pregnancy‐related complication and twice as likely to experience severe maternal morbidity when compared to white women in the United States. The risks for pregnancy‐related maternal mortality are well documented, yet Black women's experiences of life‐threatening morbidity are essentially absent in the nursing literature. The purpose of this interpretive phenomenological study was to understand the experiences of Black women who developed severe maternal morbidity. Face‐to‐face, one‐to‐one, in‐depth conversational interviews were conducted with nine Black women who experienced life‐threatening complications during childbirth or postpartum. Five essential themes emerged (1) I Only Know What I Know; (2) How You Cared for Me; (3) Race Matters; (4) Faced with Uncertainty; and (5) Still Healing. These themes illuminate the complexity of Black women's subjective interpretations of severe maternal morbidity, and reveal ways in which racism, not race, places Black women at risk for poor maternal health outcomes. The author envisions greater equity for Black mothers entrusted to nursing care, guided by nursing theories informed by these study findings.
There is no measurement problem for Humeans
Authors: Dorst Chris 
Published: October 2021

AbstractThe measurement problem concerns an apparent conflict between the two fundamental principles of quantum mechanics, namely the Schrödinger equation and the measurement postulate. These principles describe inconsistent behavior for quantum systems in so‐called “measurement contexts.” Many theorists have thought that the measurement problem can only be resolved by proposing a mechanistic explanation of (genuine or apparent) wavefunction collapse that avoids explicit reference to “measurement.” However, I argue here that the measurement problem dissolves if we accept Humeanism about laws of nature. On a Humean metaphysics, there is no conflict between the two principles, nor is there any inherent problem with the concept of “measurement” figuring into the account of collapse.
Lipopolysaccharide‐binding protein as a biomarker in oral and maxillofacial tumors
Authors: Qiao Bin , Chen Zhuo , Huang Junwen , Lam Alfred King‐Yin , Mei Zi , Li Yang , Qiao Jie 
Published: October 2021

AbstractOral and maxillofacial tumors (OMTs), such as oral squamous cell carcinoma (SCC), pleomorphic adenoma, and ameloblastoma, are common head and neck tumors. Lipopolysaccharide‐binding protein (LBP) is a type I acute reactive protein, which participates in body inflammatory response modulation through lipopolysaccharide (LPS)‐induced signaling pathway by targeting macrophages (expressing cluster of differentiation 204 [CD204]). Although it is well established that LBP is associated with the development of multiple types of cancer, little is known about the role of LBP in OMTs. This study aims to explore the expression of LBP in OMTs. Here, immunohistochemical (IHC) double staining of LBP and CD204 and enzyme‐linked immunosorbent assay (ELISA) were conducted to explore the LBP expression in OMTs. The findings demonstrated that the LBP expression in OMTs was significantly elevated (p < 0.001). In addition, the LBP expression was associated with the clinical stage (p < 0.001), T classification (p < 0.001), and lymph node metastasis (p < 0.001, except ELISA) but independent of histological grade of SCC, gender, and age in patients with SCC. The optional cutoff of the LBP serum level is 0.721 μg/ml. To conclude, LBP contributes to the development of OMTs and could be a biomarker in the screening and predicting metastasis in patients with OMTs.
Overexpression of LAG3, TIM3, and A2aR in adenoid cystic carcinoma and mucoepidermoid carcinoma
Authors: Zhang Meng‐Jie , Wu Cong‐Cong , Wang Shuo , Yang Lei‐Lei , Sun Zhi‐Jun 
Published: October 2021

AbstractObjectiveAdenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC) are the two most frequent malignancies of salivary glands. This study aims to explore the expression and migration of LAG3, TIM3, and A2aR in AdCC and MEC, and the potential relationship with oncogenic signaling molecules and immunosuppressive cytokines.Materials and MethodsCustom made human salivary gland tissue microarrays included 81 AdCCs, 52 MECs, 76 normal salivary glands (NSG), and 14 pleomorphic adenoma (PMA) samples. Immunohistochemical analysis of lymphocyte activation gene 3 (LAG3), T‐cell immunoglobulin and mucin domain‐containing protein 3 (TIM3), adenosine 2a receptor (A2aR), oncogenic phosphorylated S6 kinase (p‐S6) and ERK1/2 (p‐ERK1/2), and TGF‐β1 was performed with salivary gland tissue microarrays of human samples. The correlation of the immunostaining was analyzed based on a digital pathological system, and data were evaluated by hierarchical cluster. Further in vitro studies of knockdown immune checkpoints LAG3, TIM3, and A2aR were carried out by siRNA transfection.ResultsThe expression levels of LAG3, TIM3, and A2aR were remarkably increased in AdCC and MEC, compared with NSG and PMA samples, but were independent of pathology grade. They were closely correlated with TGF‐β1, slightly related to p‐ERK1/2 and p‐S6. After the knockdown of immune checkpoints LAG3, TIM3, and A2aR, the migration of SACC‐LM cell line was significantly reduced.ConclusionsThese results suggested that LAG3, TIM3, and A2aR are overexpressed in AdCC and MEC, may promote migration of SACC‐LM cell and correlated with TGF‐β1 and oncogenic signaling pathways.
Infantile scrotal hemangioma with transverse testicular ectopia
Authors: Sherburne Haley , Hamel Remi , Schlessinger Daniel I. , Coplen Douglas E. , Bayliss Susan 
Published: October 2021

AbstractTransverse testicular ectopia is a rare structural anomaly of abnormal testicular descent. We report a case of a 3‐month‐old boy with hemiscrotal infantile hemangioma and contralateral transverse testicular ectopia.
Geographic distribution and characteristics of the pediatric dermatology workforce in the United States
Authors: Sinha Shivani , Lin Gloria , Zubkov Micaella , Wu Rong , Feng Hao 
Published: October 2021

AbstractBackground/ObjectivesUp to 30% of pediatric primary care visits include a cutaneous complaint, yet the pediatric dermatology workforce has historically been too small to provide adequate specialized care. This study assesses the geographic distribution of pediatric dermatologists to determine physician‐to‐patient ratios, analyzes urban–rural disparities, and determines post‐fellowship migration patterns.MethodsBoard‐certified pediatric dermatologists were identified using the Society for Pediatric Dermatology’s public database, and their demographics and credentials were subsequently verified by an online search. Analysis included physician density per 100 000 children for each state and region, along with geographic distribution for rural and urban areas, based on the United States Census Bureau’s definitions. The distances between practice locations and the American Board of Dermatology‐approved Pediatric Dermatology fellowship training sites were reviewed.ResultsAn estimated 336 board‐certified pediatric dermatologists currently work in the United States with 76.8% being women and 71.1% practicing within 50 miles of the nearest fellowship program. 96.4% are located in urban areas and 3.6% in rural areas with an average ratio of 0.54 and 0.09 per 100 000 children, respectively. The average ratio of pediatric dermatologists in the United States was 0.46 per 100 000 children. On average (standard deviation), there are 6.6 (8.8) pediatric dermatologists per state but with 7 states having zero.ConclusionsThe demand for pediatric dermatologists continues to outpace the current physician availability with a disparity between urban and rural areas. Further awareness and emphasis on training and recruitment of additional pediatric dermatologists are essential to addressing this important issue.
No justice, no peace prize: Stanley “Tookie” Williams, the 1992 Bloods‐Crips truce, and the limits of racial peacekeeping
Authors: Vaught Seneca 
Published: October 2021

AbstractThis study examines the life of Crips cofounder Stanley “Tookie” Williams and the controversy surrounding his multiple nominations for the Nobel Peace Prize. After being sentenced to death for a quadruple murder, Williams underwent a period of radical transformation and became an internationally recognized ambassador for peace. From San Quentin’s death row, Williams supported several internationally recognized gang peace initiatives including the 1992 Watts truce, the 1993 Summit on Urban Peace and Justice, Hands Across America, and the 2004 Tookie Protocol for Peace. This article explores the challenges Williams faced in his evolution from a gang member to a peace activist, his role in these projects, and how neoliberal criminal justice reforms undermined his global efforts to promote grassroots peace coalitions.
Promoting risk reduction among young adults with asthma during wildfire smoke: A feasibility study
Authors: Postma Julie Marie , Odom‐Maryon Tamara , Rappold Ana G. , Haverkamp Hans , Amiri Solmaz , Bindler Ross , Whicker Justin , Walden Von 
Published: October 2021

AbstractObjective(s)This study explored the feasibility, acceptability, preliminary impact, and functionality of two risk reduction mobile application (app) interventions on asthma outcomes as compared to a control arm during wildfire season.DesignThree‐arm, 8‐week randomized clinical trial.SampleSixty‐seven young adults with asthma were enrolled.MeasurementsThe Asthma Control Test, forced expiratory volume in one second (FEV1) and the System Usability Scale were measured at baseline, 4, and 8 weeks. The Research Attitude Scale was administered at 8 weeks. Twenty participants from the two intervention arms completed an optional survey and six were interviewed after completing the study.InterventionBoth intervention arms could access Smoke Sense Urbanova, an app that supports reducing risks from breathing wildfire smoke. The Smoke Sense Urbanova Plus arm also monitored their daily FEV1, received air quality notifications, and accessed preventive tips and a message board.ResultsMost participants agreed the app and spirometer were usable and their privacy and confidentiality were maintained. No adverse events were reported.ConclusionsParticipant‐identified recommendations will support intervention refinement and testing. This research supports asthma self‐management tools that public health nurses and community health workers can recommend for at‐risk populations.
Global 3′‐untranslated region landscape mediated by alternative polyadenylation during meiotic maturation of pig oocytes
Authors: Wu Zi‐Wei , Mou Qiao , Fang Ting , Wang Yi , Liang Hao , Wang Chonglong , Du Zhi‐Qiang , Yang Cai‐Xia 
Published: October 2021

AbstractAlternative polyadenylation affects the length and composition of 3′‐untranslated region (3′‐UTR) and regulates mRNA stability or translational activity to affect important biological processes. However, global 3′‐UTR landscape and its relationship with gamete maturation remain less studied. Here, we analysed our previously reported single‐cell RNA‐seq data of germinal vesicle and metaphase II stage oocytes in pigs to systematically catalogue the 3′‐UTR dynamics during oocyte maturation. Two softwares (DaPars and APAtrap) were employed and identified 110 and 228 mRNAs with significantly different 3′‐UTRs (adjusted p ≤ .05), respectively. Gene enrichment analyses found signalling pathways related with biological processes of female gametophyte production, methyltransferase activity and mRNA surveillance (DaPars) and cell cycle process, regulation of ERK1 and ERK2 cascade, regulation of translation, spindle organization, kinetochore, condensed chromosome and progesterone‐mediated oocyte maturation (APAtrap), respectively. Moreover, 18 of 110 mRNAs (|△PDUI| ≥ 0.25 and |log2PDUI ratio| ≥ 0.59) and 15 of 228 mRNAs (Perc. diff. ≥ 0.5) were with greater difference of 3′‐UTR length or abundance, and integrative genomics viewer analysis further identified 4 (Alg10, Hadhb, Hsd17b4 and Sbds) of 18 mRNAs to be with 3′‐UTR length differed ≥150 bp and 6 (Gcc1, Hnrnpa2b1, Lsm6, Prpf18, Sfr1 and Ust) of 15 mRNAs to be with 3′‐UTR abundance extremely differed. Furthermore, the location, sequences and number of cis‐elements were predicted, which were shown to derange cytoplasmic polyadenylation element, poly(A) site and microRNA binding sites within 3′‐UTRs of Alg10, Hadhb, Hsd17b4 and Sbds mRNAs. Taken together, global 3′‐UTR landscape changes dynamically with oocyte meiotic maturation, potentially involved in regulating oocyte meiotic process in pigs.
Pulp chamber access alternative in pulpectomies in a child with Wolff‐Parkinson‐White syndrome. A case report
Authors: Vilca Velazco Mirella Francis , Lavado García Lenny , Torres Ramos Gilmer , López Ramos Roxana Patricia 
Published: October 2021

AbstractBackgroundWolff‐Parkinson‐White syndrome is a congenital abnormality of the heart. Patients with this syndrome and multiple dental caries with pulp exposure may require comprehensive dental treatment under general anesthesia. Pulpectomy is performed in primary teeth with pulp expose. This treatment in anterior teeth requires palatal access and the majority there is no good visibility, requiring more time to perform. Therefore, this case aimed to demonstrate a pulp chamber opening alternative in pulpectomies in a child with Wolff‐Parkinson‐White syndrome.Case PresentationA 3‐year‐old female patient with Wolff‐Parkinson‐White syndrome and multiple dental caries with reversible pulpitis in anterior upper teeth. The dental treatment was performed under general anesthesia. Due to abundant hemorrhage in anterior upper teeth, pulpectomies were performed, which pulp chamber openings were modified by labial and the treatment itself was completed. After, these teeth were rehabilitated with direct restorative veneers using light‐curing composite resin. The follow‐up at 12 months showed an absence of evidence clinic and radiographic.ConclusionThis case demonstrated the pulp chamber opening performed by labial in pulpectomy is an effective and viable alternative to reduce operative time and improve visibility in pulpotomies in a child with Wolff‐Parkinson‐White syndrome.