bluuebunny/crossref_metadata_2025_split huggingface dataset:
The coagulation factor IX (F9) loss of function prevents the cell cycle arrest induced by CDK4/6 inhibitors treatment
Authors: Carpintero-Fernández Paula , Borghesan Michela , Eleftheriadou Olga , Fafián-Labora Juan Antonio , Mitchell Tom P. , Nightingale Tom D. , Mayán María D. , O’Loghlen Ana 
Published: November 2021

SUMMARYDuring this last decade the development of pro-senescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce senescence and have showed efficacy in reducing tumour growth in breast cancer patients. However, even though cancer cells are arrested after CDK4/6 inhibitor treatment, genes regulating senescence in this context are still unknown limiting their anti-tumour activity. Here, using a functional genome wide CRISPR/Cas9 genetic screen we found several genes that synergistically participate in the proliferation arrest induced by the CDK4/6 inhibitor, Palbociclib. We find that downregulation of the coagulation factor IX (F9) using sgRNA and shRNA prevents the cell cycle arrest and senescent-like phenotype induced in MCF7 breast tumour cells upon Palbociclib treatment. These results were confirmed using another breast cancer cell line and with an alternative CDK4/6 inhibitor, Abemaciclib, and further tested in a panel of 22 cancer cells. While F9 knockout reduces senescence, treatment with a recombinant F9 protein was sufficient to induce a cell cycle arrest and senescence-like state in MCF7 tumour cells. Besides, endogenous F9 is upregulated in different human primary cells cultures undergoing senescence. Importantly, bioinformatics analysis of cancer datasets suggest a role for F9 in human tumours. Altogether, these data collectively propose key genes involved in CDK4/6 inhibitors response that will be useful to design new therapeutic strategies in personalized medicine in order to increase their efficiency, stratify patients and avoid drug resistance.
Structure transforming for constructing constraint force field in musculoskeletal robot
Authors: Zhong Shanlin , Chen Ziyu , Zhou Junjie 
Published: November 2021

Purpose
Human-like musculoskeletal robots can fulfill flexible movement and manipulation with the help of multi joints and actuators. However, in general, sophisticated structures, accurate sensors and well-designed control are all necessary for a musculoskeletal robot to achieve high-precision movement. How to realize the reliable and accurate movement of the robot under the condition of limited sensing and control accuracy is still a bottleneck problem. This paper aims to improve the movement performance of musculoskeletal system by bio-inspired method.

Design/methodology/approach
Inspired by two kinds of natural constraints, the convergent force field found in neuroscience and attractive region in the environment found in information science, the authors proposed a structure transforming optimization algorithm for constructing constraint force field in musculoskeletal robots. Due to the characteristics of rigid-flexible coupling and variable structures, a constraint force field can be constructed in the task space of the musculoskeletal robot by optimizing the arrangement of muscles.

Findings
With the help of the constraint force field, the robot can complete precise and robust movement with constant control signals, which brings in the possibility to reduce the requirement of sensing feedback during the motion control of the robot. Experiments are conducted on a musculoskeletal model to evaluate the performance of the proposed method in movement accuracy, noise robustness and structure sensitivity.

Originality/value
A novel concept, constraint force field, is proposed to realize high-precision movements of musculoskeletal robots. It provides a new theoretical basis for improving the performance of robotic manipulation such as assembly and grasping under the condition that the accuracy of control and sensory are limited.
Applicability of a digitalization model based on augmented reality for building construction education in architecture
Authors: Seyman Guray Tayibe , Kismet Burcu 
Published: November 2021

Purpose
The purpose of this paper is to introduce a digitalization model (DM) for building construction courses in architectural education as a response to the recent emerging technologies in the era of digital transformations. This DM is developed and applied through augmented reality (AR) technologies to boost perception, understandings and ability to solve building construction details.

Design/methodology/approach
Based on a thorough review of recent technologies like AR, virtual reality (VR), building information modelling (BIM) and their applications in architectural education, the methodology involves the generation of a model, its application and evaluation. The model is based on the integration of BIM and AR which is applied into a third year “Building Construction Project” course. Each student has designed a residential building and accordingly prepared the construction drawings by adapting the DM. An online survey –based on Technology Acceptance Model – is conducted to evaluate the DM by quantitative data analysis from SPSS and Excel.

Findings
The key findings of the study include the following items: determination of the proper digital tools, the definition of the steps and workflow based on the building project phases to develop construction drawings and define precise details effectively. By the help of this, the DM is generated and applied. According to the survey and results, the DM which involves BIM-based AR is considered as beneficial, highly motivating and providing better perception on construction details.

Originality/value
Implication of AR/VR technologies is frequently seen in design studios, whereas building construction courses state its traditional approach. However, there is a huge potential in the digitalization of building construction education by increasing the perception of students together with the increased level of communication. The study aims to close the gap of digitalization by proposing a DM, which brings a systematic approach considering each phase of building construction project as conceptual, schematic, design development and construction documents by using BIM integrated AR. Moreover, the novel model specifically brings a new approach by generation of QR codes for construction details to embed videos or simulations into the two-dimensional drawing sheets. Furthermore, the DM proposes a new approach to satisfy emerging needs and requirements of the Architecture Engineering Construction industry.
Digital dissemination skills in public libraries
Authors: Skøtt Bo 
Published: November 2021

Purpose
The purpose of this paper is to investigate what con`sequences the digitisation of public libraries’ knowledge dissemination and the transition to online services has, for library staff members’ perception of their skills. This discussion is interesting because library staff members, by politicians, stakeholders, and other opinion makers, have been appointed as key facilitators of citizens’ continued attachment to civil society and the labour market.

Design/methodology/approach
This study is based on interviews with library staff members at Danish public libraries. Empirical data were collected through semi-structured e-mail interviews, based on an interview formula, and via follow-up telephone conversations. Library professional rapports and research literature were identified and applied as a theoretical framework in the creation of the analytical apparatus.

Findings
There were several different explanatory models available when respondents had to articulate their current challenges. The first model regarded the library staff members’ lack of skills as a political-organisational issue, occurring because of a lack of invest in their continuing education. Continuing education had therefore become a personal matter. The second model highlighted the library staff members’ lack of skills as an individual, library professional problem, where the responsibility for solving the problem lay with the individual employee.

Originality/value
Several studies have been conducted on library staff members’ skills and how they change, due to the transition to digital forms of dissemination. The present study strives to give employees a voice, which is why the respondents’ experiences are the starting point for the analytical work. Such studies are essential to understanding the extent and nature of the problem.
Innovative solutions to tap “Micro, Small and Medium Enterprises” (MSME) market
Authors: Hakeem Muhammad Mohsin 
Published: November 2021

Purpose
The purpose of this paper is to indicate an innovative solution to address the financing issues faced by “Micro-, Small and Medium Enterprises” (MSME) in emerging economies.

Design/methodology/approach
Islamic Financial Institutions (IFIs) especially Islamic banks are competing for high net worth individuals, whereas the MSME sector is largely untapped. A collaborative model for IFIs is suggested, to explore the MSME sector. Islamic Non-Banking Financial Institutions (NBFIs) are operating in these markets through their extensive gross route networks. The multistep collaborative model proposes “Special Purpose Entity (SPE)” partially owned by a single Islamic Bank or consortium and NBFI/s. SPEs can be incorporated with a defined scope, focus areas, risk profile, budget and shareholding patterns.

Findings
Risk and profit sharing instruments also known as Musharakah and Mudarabah have less than 6 percent share within total financing offered by Islamic banks globally. Risk sharing products offered by Islamic banks are not targeting this sector due to the underdevelopment of instruments, lack of knowledge and resources. Proposed SPEs can operate regionally with a concentration on specific business sectors.

Originality/value
The SPE model would enable Islamic banks to enter the huge MSME market while mitigating risk. On the contrary, it would enable the large segments of emerging economies (bottom 40 percent population of developing nations) to get involved and actively play their role to attain long-term development goals.
Reflection of Maqāṣid al-Sharī'ah in the classical Fiqh al-Awqāf
Authors: Abdullah Mohammad 
Published: November 2021

PurposeThis paper aims to analyse the Sharī'ah premises of classical waqf doctrines followed by critically analysing the framework of waqf jurisprudence (fiqh al-awqāf) from a Maqāṣid al-Sharī'ah (the higher objectives of Islamic law) perspective. The objective of examining the jurisprudential framework of waqf from a maqāṣid perspective is to contextualise the scope of dynamism and innovation in the modern waqf structure.Design/methodology/approachFor examining the jurisprudential aspects of classical fiqh al-awqāf with a special reference to Maqāṣid al-Sharī'ah, the paper analyses the classical waqf books and treatises from the four Sunni schools of jurisprudence by employing a textual analysis method.FindingsThe paper finds that the key constituents of maqāṣid are interwoven in the classical discourse of waqf rulings. It finds that in deriving the principles of waqf, the jurists ensured that the essentialities of Maqāṣid al-Sharī'ah are subtly intermingled with the necessary components of fiqhī principles. Deconstructing the applied analogical reasoning of the classical jurists in deriving the waqf rulings, this paper provides recommendations for maqāṣid-oriented application of waqf in the modern context.Research limitations/implicationsThis study does not cover either the historical contribution of waqf among the Muslim societies nor does it touch on the empirical aspects of modern waqf. Rather, the focus of the study is limited to analysing the classical jurisprudential rulings of waqf and their distillation process from a Maqāṣid al-Sharī'ah perspective. The study has good implication for modern awqāf, which need to be created, managed and directed in the spirit of Maqāṣid al-Sharī'ah.Practical implicationsThe key objective of adopting the maqāṣid framework for the analysis of fiqh al-awqāf in its classical permutations is to learn how to utilise the maqāṣid approach as a baseline for the deduction of new waqf rulings in a contextualised term.Originality/valueThe novelty of the paper lies in its examination of the classical waqf rulings distillation process, and the cogent intersection of Maqāṣid al-Sharī'ah with the principles of fiqh. By delving into the Sharī'ah premises of classical waqf jurisprudence through the lens of maqāṣid, the paper adds an original value and fills an existing gap in the available literature.
The business financial inclusion benefits from an Islamic point of view: a qualitative inquiry
Authors: Umar Umar Habibu 
Published: November 2021

PurposeThis study explores the benefits of business financial inclusion from the Islamic perspective in Nigeria by selecting Kano state as a case study.Design/methodology/approachPrimary data were generated through semi-structured interviews with experts who comprised professional accountants/consultants and experienced traders. Thematic analysis was applied to examine the data collected. In addition, observations were made in some selected stores and shops to complement the interview results.FindingsThe study finds that the benefits of business financial inclusion include recordkeeping improvement, reduction of the risks of bad debts, reduction of the risks associated with cash, enhancing business zakāh for poverty alleviation, sales improvement and business growth, getting supports from government and other development organizations and the provision of employment opportunities.Research limitations/implicationsThis study is purely qualitative, and, as such, it has some limitations in terms of generalization.Practical implicationsThe practical implication of this study is that the use of electronic payment methods, especially point of sales, enhances the business financial inclusion, which consequently maximizes their wealth and contributes to the reduction of poverty to the barest minimum in the society.Social implicationsThe social implication of the findings is that businesses that are financially included are in a better position to discharge religious, philanthropic and other benevolent activities, such as zakāh, qard hasan, waqf and sadaqah, for the welfare of the ummah.Originality/valueThe study points out the benefits of financial inclusion not only to businesses but also to other members of the society at large.
Complications associated with the use of silicone oil in vitreoretinal surgery: A systemic review and meta‐analysis
Authors: Valentín‐Bravo Fco. Javier , García‐Onrubia Luis , Andrés‐Iglesias Cristina , Valentín‐Bravo Eduardo , Martín‐Vallejo Javier , Pastor José Carlos , Usategui‐Martín Ricardo , Pastor‐Idoate Salvador 
Published: November 2021

AbstractSilicone oil (SO) still represents the main choice for long‐term intraocular tamponade in complicated vitreoretinal surgery. This review compared the complications associated with the use of SO and other vitreous substitutes after pars plana vitrectomy in patients with different underlying diseases. Meta‐analysis was conducted in accordance with PRISMA guidelines. We retrieved randomized clinical trials (RCTs), retrospective case–control and cohort studies evaluating the risk of using SO, published between 1994 and 2020, conducting a computer‐based search of the following databases: PubMed, Web of Science, Scopus and Embase. Primary outcome was the rate of complications such as intraocular hypertension, retinal re‐detachment, unexpected vision loss or hypotony. Secondary outcome was to compare the rate of adverse events of different SO viscosities, especially emulsification. Forty‐three articles were included. There were significant differences in intraocular hypertension (p = 0.0002, OR = 1.66; 95% CI = 1.27–2.18) and the rate of retinal re‐detachment (p < 0.0009, OR = 0.65; 95% CI = 0.50–0.64) between SO and other agents, including placebo. However, there were no differences in other complication rates. Silicone oil (SO)‐emulsification rate was non‐significantly higher in low than high SO viscosity, and results from other complications were comparable in both groups. The high quality of most of the studies included in this study is noteworthy, which provides some certainty to the conclusions. Among them is the high variability of the SO residence time. The fact that ocular hypertension and not hypotension is related to SO use. A clear relationship is not found for the so‐called unexplained vision loss, which affects a significant percentage of eyes. Re‐detachment cases are less if SO is used and that surprisingly there does not seem to be a relationship in the percentage of emulsification between the low‐ and high‐viscosity silicones. All these data warrant more standardized prospective studies.
Peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha protects a fibrotic liver from partial hepatectomy‐induced advanced liver injury through regulating cell cycle arrest
Authors: Zhang Linzhong , Wang Wei , Liu Lipeng , Zhang Yanghao , Zhang Xiuying 
Published: November 2021

AbstractBackgroundA fibrotic liver may have an impaired regenerative capacity. Because liver transplantation is donor limited, understanding the regenerative ability of a fibrotic liver is important.MethodsA two‐thirds partial hepatectomy (PH) was performed in C57Bl/6 mice with or without carbon tetrachloride (CCl4) treatment. Liver regeneration in the fibrotic liver after PH was assessed by the intrahepatic expression of the cell cycle regulators p53, p21, cyclin D1, c‐Fos and CDK2 using Western blot analysis. In addition, the expression of PGC‐1α and the cell proliferation‐related proteins PCNA and phosphate histone H3 was determined by Western blot and immunohistochemical staining analyses. Histone epigenetic modification of the PGC‐1α promoter was investigated through chromatin immunoprecipitation (ChIP) and reverse transcription–quantitative polymerase chain reaction (RT‐qPCR) assays. The impact of PGC‐1α on liver regeneration after PH was further evaluated in PGC‐1α‐knockout mice.ResultsA decreased expression of PGC‐1α and liver regeneration‐related genes in the fibrotic liver was detected after a PH. Histone acetylation at the PGC‐1α promoter led to increases in PGC‐1α expression and the survival rate in the fibrotic group after a PH. PGC‐1α‐mediated liver regeneration was further demonstrated in PGC‐1αf/falbcre+/0 mice.ConclusionTargeting PGC‐1α may represent a strategy to improve the treatment of PH in patients with liver fibrosis.
Which mixed depression model? A comparison between DSM‐5‐defined mixed features and Koukopoulos' criteria
Authors: Mineo Ludovico , Rodolico Alessandro , Spedicato Giorgio A. , Aguglia Andrea , Bolognesi Simone , Concerto Carmen , Cuomo Alessandro , Goracci Arianna , Serafini Gianluca , Maina Giuseppe , Fagiolini Andrea , Amore Mario , Aguglia Eugenio 
Published: November 2021

AbstractBackgroundThe criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition “with mixed features specifier” (DSM‐5 MFS) are considered controversial since they include only typical manic symptoms. By contrast, Koukopoulos developed an alternative model of mixed depression (MxD) focusing primarily on the excitatory component.ObjectiveTo compare DSM‐5 MFS and Koukopoulos' MxD (KMxD) in terms of prevalence, associated clinical variables, and discriminative capacity for bipolar depression in patients with major depressive episode (MDE).MethodsA total of 300 patients with MDE—155 with major depressive disorder and 145 with bipolar disorder (BD)—were recruited. The discriminative capacity of DSM‐5 MFS and KMxD criteria for BD was estimated using the area under the curves of receiver operating characteristic (ROC_AUC). The clinical variables associated with these two diagnostic constructs were assessed by performing a logistic regression.ResultsA total of 44 and 165 patients met the DSM‐5 MFS and KMxD criteria, respectively. The ROC_AUCs and their confidence intervals for BD according to DSM‐5 MFS and KMxD were 77.0% (72.0%‐82.1%) and 71.9% (66.2%‐77.7%), respectively. The optimal thresholds (combining sensitivity and specificity measures) for BD diagnosis were ≥1 (77%/68%) for DSM‐5 MFS and ≥3 symptoms (78%/66%) for KMxD. However, considering the DSM‐5 MFS cut‐off (≥3 symptoms), the specificity (97%) increased at the expense of sensitivity (26%).ConclusionsKMxD and DSM‐5‐MFS showed an overlapping discriminative capacity for bipolar depression. The current diagnostic threshold of DSM‐5 MFS did not prove to be very inclusive, if compared with the greater diagnostic sensitivity of KMxD, which also yielded better association with clinical variables related to mixedness.
Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination
Authors: Theotokis Paschalis , Kesidou Evangelia , Mitsiadou Dimitra , Petratos Steven , Damianidou Olympia , Boziki Marina , Chatzidimitriou Anastasia , Grigoriadis Nikolaos 
Published: November 2021

AbstractExperimental autoimmune encephalomyelitis (EAE) is a basic and reliable model used to study clinical and pathological hallmarks of multiple sclerosis (MS) in rodents. Several studies suggest neural precursor cells (NPCs) as a significant research tool while reporting that transplanted NPCs are a promising therapeutic approach to treating neurological disorders, such as MS. The main objective was to approach a preclinical, in vivo scenario of oligodendrogenesis with NPCs, targeting the main chronic demyelinated lumbosacral milieu of EAE, via the least invasive delivery method which is lumbar puncture. We utilized MOG35‐55 peptide to induce EAE in C57BL/6 mice and prior to the acute relapse, we intervened with either the traceable GFP+ cellular therapy or saline solution in the intrathecal space of their lumbar spine. A BrdU injection, which enabled us to monitor endogenous proliferation, marked the endpoint 50 days post‐induction (50 dpi). Neuropathology with high‐throughput, triple immunofluorescent, and transmission electron microscopy (TEM) data were extracted and analyzed. The experimental treatment attenuated the chronic phase of EAE (50 dpi; score <1) following an acute, clinical relapse. Myelination and axonal integrity were rescued in the NPC‐treated animals along with suppressed immune populations. The differentiation profile of the exogenous NPCs and endogenous BrdU+ cells was location‐dependent where GFP+‐rich areas drove undifferentiated phenotypes toward the oligodendrocyte lineage. In situ oligodendrocyte enrichment was demonstrated through increased (p < 0.001) gap junction channels of Cx32 and Cx47, reliable markers for proliferative oligodendroglia syncytium. TEM morphometric analysis ultimately manifested an increased g‐ratio in lumbosacral fibers of the recovered animals (p < 0.001). Herein, we suggest that a single, lumbar intrathecal administration of NPCs capacitated a viable cellular load and resulted in clinical and pathological amelioration, stimulating resident OPCs to overcome the remyelination failure in EAE demyelinating locale.