bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Systematics of Chlorine, Lithium, and Boron andδ37Cl,δ7Li, and δ11B in the Hydrothermal System of the Yellowstone Plateau Volcanic Field
Authors: Cullen Jeffrey T. , Hurwitz Shaul , Barnes Jaime D. , Lassiter John C. , Penniston‐Dorland Sarah , Meixner Anette , Wilckens Frederike , Kasemann Simone A. , McCleskey R. Blaine 
Published: April 2021

AbstractChlorine, lithium, and boron are trace elements in rhyolite but are enriched in groundwater flowing through rhyolite because they tend to partition into the fluid phase during high‐temperature fluid‐rock reactions. We present a large data set of major element and δ37Cl, δ7Li, and δ11B compositions of thermal water and rhyolite from Yellowstone Plateau Volcanic Field (YPVF). The Cl/B, Cl/Li, δ37Cl (−0.2‰ to +0.7‰), and δ11B (−6.2‰ to −5.9‰) values of alkaline‐chloride thermal waters reflect high‐temperature leaching of chlorine, lithium, and boron from rhyolite that has δ37Cl and δ11B values of +0.1‰ to +0.9‰ and −6.3‰ to −6.2‰, respectively. Chlorine and boron are not reactive, but lithium incorporation into hydrothermal alteration minerals result​s in a large range of Cl/Li, B/Li, and δ7Li (−1.2‰ to +3.8‰) values in thermal waters. The relatively large range in δ7Li values of thermal waters reflects a large range of values in rhyolite. Large volumes of rhyolite must be leached to account for the chloride, lithium and boron fluxes, implying deep groundwater flow through rhyolite flows and tuffs representing Yellowstone's three eruptive cycles (∼2.1 Ma). Lower Cl/B values in acid‐sulfate waters result from preferential partitioning of boron into the vapor phase and enrichment in the near‐surface water condensate. The Cl/B, Cl/Li, δ7Li (−0.3‰ to +2.1‰), and δ11B (−8.0‰ to −8.1‰) values of travertine depositing calcium‐carbonate thermal waters which discharge in the northern and southern YPVF suggest that chlorine, lithium, and boron are derived from Mesozoic siliciclastic sediments which contain detrital material from the underlying metamorphic basement.
Surface Melt and Runoff on Antarctic Ice Shelves at 1.5°C, 2°C, and 4°C of Future Warming
Authors: Gilbert E. , Kittel C. 
Published: April 2021

AbstractThe future surface mass balance (SMB) of Antarctic ice shelves has not been constrained with models of sufficient resolution and complexity. Here, we force the high‐resolution Modèle Atmosphérique Régional with future simulations from four CMIP models to evaluate the likely effects on the SMB of warming of 1.5°C, 2°C, and 4°C above pre‐industrial temperatures. We find non‐linear growth in melt and runoff which causes SMB to become less positive with more pronounced warming. Consequently, Antarctic ice shelves may be more likely to contribute indirectly to sea level rise via hydrofracturing‐induced collapse, which facilitates accelerated glacial discharge. Using runoff and melt as indicators of ice shelf stability, we find that several Antarctic ice shelves (Larsen C, Wilkins, Pine Island, and Shackleton) are vulnerable to disintegration at 4°C. Limiting 21st century warming to 2°C will halve the ice shelf area susceptible to hydrofracturing‐induced collapse compared to 4°C.
Identifying Key Environmental Factors Explaining Temporal Patterns of DOC Export From Watersheds in the Conterminous United States
Authors: Wei Xinyuan , Hayes Daniel J. , Fernandez Ivan , Zhao Jianheng , Fraver Shawn , Chan Catherine , Diao Jiaojiao 
Published: April 2021

AbstractThe export of dissolved organic carbon (DOC) from a watershed is a key component of the terrestrial biosphere carbon cycle. There is a need to improve our understanding of how and by how much various environmental factors are driving the temporal patterns of DOC export in order to accurately model and evaluate terrestrial carbon storage and fluxes. In this synthesis, we compiled observational data sets from 14 watersheds in the conterminous United States spanning the time period from 1981 to 2017. We used these data sets to examine the relative impacts of various climate, atmospheric deposition, and land cover factors on the temporal patterns of DOC export across watersheds of different sizes and landscape conditions, as well as the time‐series autocorrelation of DOC export. Our results suggest that the dominant factor on an annual scale was the amount of precipitation, which had a positive correlation with DOC export from a watershed. Overall increasing nitrogen deposition was coincident with increasing DOC export, and increasing sulfur deposition was coincident with declining DOC export. The seasonal pattern of DOC export was strongly regulated by air temperature, the long‐term trend was negatively influenced by increasing sulfur deposition, and no obvious autocorrelation was detected in DOC export. In addition, higher rates of DOC export were positively correlated with greater area of wetlands within a watershed, but was not found to be strongly related to any of the other land cover types.
S wave Velocity Structure of the Crust and Upper Mantle Beneath Shanxi Rift, Central North China Craton and its Tectonic Implications
Authors: Cai Yan , Wu Jianping , Rietbrock Andreas , Wang Weilai , Fang Lihua , Yi Shuang , Liu Jing 
Published: April 2021

AbstractThe Shanxi rift is located in the central part of the North China Craton (NCC). With strong tectonic deformation and intense seismic activity, its crust‐mantle deformation and deep structure have always attracted wide attention. Using teleseismic events observed in a dense network of 610 temporary and 127 permanent stations in the central NCC, we obtained the crust‐mantle S wave velocity structures by the joint inversion method of receiver functions and surface wave dispersion data. Our results show that the crust thickens in the northern part of the Shanxi rift (41 km) and thins in the southern part (35 km). The Taiyuan and Linfen basins, located in the central part, have high‐velocity zones in the lower crust and upper mantle; beneath the Yuncheng basin in the south, there are low‐velocity zones in the lower crust and uppermost mantle (30–80 km); the Datong basin, located in the northern part of the rift, exhibits a wide range of low‐velocity anomalies in the middle to lower crust and upper mantle. We speculate that the destruction of the NCC and associated lithospheric thinning had a significant impact on the southern part of the rift, but is still in its early stage in the central part, which retains most of the craton features. An upwelling of the asthenospheric magma occurred beneath the western part of the Datong basin. The horizontal deflection of the asthenospheric flow causes low‐velocity anomalies in its surrounding area, which is consistent with LAB topography.
Primary and Net Ecosystem Production in a Large Lake Diagnosed From High‐Resolution Oxygen Measurements
Authors: Fernández Castro Bieito , Chmiel Hannah Elisa , Minaudo Camille , Krishna Shubham , Perolo Pascal , Rasconi Serena , Wüest Alfred 
Published: April 2021

AbstractThe rates of gross primary production (GPP), ecosystem respiration (R), and net ecosystem production (NEP) provide quantitative information about the cycling of carbon and energy in aquatic ecosystems. In lakes, metabolic rates are often diagnosed from diel oxygen fluctuations recorded with high‐resolution sondes. This requires that the imprint of ecosystem metabolism can be separated from that of physical processes. Here, we quantified the vertical and temporal variability of the metabolic rates of a deep, large, mesotrophic lake (Lake Geneva, Switzerland–France) by using a 6‐month record (April–October 2019) of high‐frequency, depth‐resolved (0–30 m) dissolved oxygen measurements. Two new alternative methods (in the time and frequency domain) were used to filter low‐frequency basin‐scale internal motions from the oxygen signal. Both methods proved successful and yielded consistent metabolic estimates showing net autotrophy (NEP = GPP − R = 55 mmol m−2 day−1) over the sampling period and depth interval, with GPP (235 mmol m−2 day−1) exceeding R (180 mmol m−2 day−1). They also revealed significant temporal variability, with at least two short‐lived blooms occurring during calm periods, and a vertical partitioning of metabolism, with stronger diel cycles and positive NEP in the upper ∼10 m and negative NEP below, where the diel oxygen signal was dominated by internal motions. The proposed methods expand the range of applicability of the diel oxygen technique to large lakes hosting energetic, low‐frequency internal motions, offering new possibilities for unveiling the rich spatiotemporal metabolism dynamics in these systems.
Relationship Between the Ozone and Water Vapor Columns on Mars as Observed by SPICAM and Calculated by a Global Climate Model
Authors: Lefèvre F. , Trokhimovskiy A. , Fedorova A. , Baggio L. , Lacombe G. , Määttänen A. , Bertaux J.‐L. , Forget F. , Millour E. , Venot O. , Bénilan Y. , Korablev O. , Montmessin F. 
Published: April 2021

AbstractOzone (O3) in the atmosphere of Mars is produced following the photolysis of CO2 and is readily destroyed by the hydrogen radicals (HOx) released by the photolysis and oxidation of water vapor. As a result, an anti‐correlation between ozone and water vapor is expected. We describe here the O3‐H2O relationship derived from 4 Martian years of simultaneous observations by the SPICAM spectrometer onboard the Mars Express spacecraft. A distinct anti‐correlation is found at high latitudes, where the O3 column varies roughly with the −0.6 power of the H2O column. The O3 and H2O columns are uncorrelated at low latitudes. To evaluate our quantitative understanding of the Martian photochemistry, the observed O3‐H2O relationship is then compared to that predicted by a global climate model with photochemistry. For identical model and observed abundances of H2O, the model underpredicts observed ozone by about a factor of 2 relative to SPICAM when using the currently recommended gas‐phase chemistry. Sensitivity studies employing low‐temperature CO2 absorption cross sections, or adjusted kinetics rates, do not solve this bias. Taking into account potential heterogeneous processes of HOx loss on clouds leads to a significant improvement, but only at high northern latitudes. More broadly, the modeled ozone deficits suggest that the HOx‐catalyzed photochemistry is too efficient in our simulations. This problem is consistent with the long‐standing underestimation of CO in Mars photochemical models, and may be related to similar difficulties in modeling O3 and HOx in the Earth's upper stratosphere and mesosphere.
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1
Authors: Li Jia-wei , Wang Rong-liang , Xu Jia , Sun Kuo-yang , Jiang Hui-ming , Sun Zi-ying , Lv Zhong-yang , Xu Xing-quan , Wu Rui , Guo Hu , Jiang Qing , Shi Dong-quan 
Published: April 2021

AbstractOxidative stress-related cartilage degeneration, synovitis, and joint pain play vital roles in the progress of osteoarthritis (OA). Anti-oxidative stress agents not only prevent structural damage progression but also relieve OA-related pain. In this study, we investigated the therapeutic effect of methylene blue (MB), a classical and important anti-oxidant with strong neural affinity. Experimental OA was established in rats by radial transection of medial collateral ligament and medial meniscus (MCLT + MMT) of the right knee joint. The OA rats received intra-articular injection of MB (1 mg/kg) every week starting one week after surgery. We showed that MB administration exerted significant cartilage protection, synovitis inhibition as well as pain relief in OA rats. In human chondrocytes and fibroblast-like synoviocytes, MB significantly attenuated tert-butyl hydroperoxide (TBHP)-induced inflammatory response and oxidative stress. We demonstrated that these effects of MB resulted from dual targets of important antioxidant enzymes, Nrf2 and PRDX1, which also mutually reinforcing and participated in an interaction. Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1. Taken together, these results suggest that MB ameliorates oxidative stress via Nrf2/PRDX1 regulation to prevent progression and relieve pain of OA.
Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
Authors: Zhu Xiangjia , Du Yu , Li Dan , Xu Jie , Wu Qingfeng , He Wenwen , Zhang Keke , Zhu Jie , Guo Linying , Qi Ming , Liu Ailin , Qi Jiao , Wang Guangyu , Meng Jiaqi , Yang Zhenglin , Zhang Kang , Lu Yi 
Published: April 2021

AbstractHigh myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings are replicated in two independent mouse models of high myopia. Mechanistic studies show that the transcription factor MAF plays an essential role in up-regulating β/γ-crystallins in high myopia, by direct activation of the crystallin gene promoters and by activation of TGF-β1-Smad signaling. Our results establish lens morphological and molecular changes as a characteristic feature of high myopia, and point to the dysregulation of the MAF-TGF-β1-crystallin axis as an underlying mechanism, providing an insight for therapeutic interventions.
Hydrodynamic instability at impact interfaces and planetary implications
Authors: Ravid Avi , Citron Robert I. , Jeanloz Raymond 
Published: April 2021

AbstractImpact-induced mixing between bolide and target is fundamental to the geochemical evolution of a growing planet, yet aside from local mixing due to jetting – associated with large angles of incidence between impacting surfaces – mixing during planetary impacts is poorly understood. Here we describe a dynamic instability of the surface between impacting materials, showing that a region of mixing grows between two media having even minimal initial topography. This additional cause of impact-induced mixing is related to Richtmyer-Meshkov instability (RMI), and results from pressure perturbations amplified by shock-wave refraction through the corrugated interface between impactor and target. However, unlike RMI, this new impact-induced instability appears even if the bodies are made of the same material. Hydrocode simulations illustrate the growth of this mixing zone for planetary impacts, and predict results suitable for experimental validation in the laboratory. This form of impact mixing may be relevant to the formation of stony-iron and other meteorites.
Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
Authors: Peruzzo Roberta , Corrà Samantha , Costa Roberto , Brischigliaro Michele , Varanita Tatiana , Biasutto Lucia , Rampazzo Chiara , Ghezzi Daniele , Leanza Luigi , Zoratti Mario , Zeviani Massimo , De Pittà Cristiano , Viscomi Carlo , Costa Rodolfo , Szabò Ildikò 
Published: April 2021

AbstractMitochondrial diseases impair oxidative phosphorylation and ATP production, while effective treatment is still lacking. Defective complex III is associated with a highly variable clinical spectrum. We show that pyocyanin, a bacterial redox cycler, can replace the redox functions of complex III, acting as an electron shunt. Sub-μM pyocyanin was harmless, restored respiration and increased ATP production in fibroblasts from five patients harboring pathogenic mutations in TTC19, BCS1L or LYRM7, involved in assembly/stabilization of complex III. Pyocyanin normalized the mitochondrial membrane potential, and mildly increased ROS production and biogenesis. These in vitro effects were confirmed in both DrosophilaTTC19KO and in Danio rerioTTC19KD, as administration of low concentrations of pyocyanin significantly ameliorated movement proficiency. Importantly, daily administration of pyocyanin for two months was not toxic in control mice. Our results point to utilization of redox cyclers for therapy of complex III disorders.
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
Authors: Nakamura Atsuo , Kurihara Shin , Takahashi Daisuke , Ohashi Wakana , Nakamura Yutaka , Kimura Shunsuke , Onuki Masayoshi , Kume Aiko , Sasazawa Yukiko , Furusawa Yukihiro , Obata Yuuki , Fukuda Shinji , Saiki Shinji , Matsumoto Mitsuharu , Hase Koji 
Published: April 2021

AbstractIntestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological processes. Increased colonic luminal polyamines promote longevity in mice. However, no direct evidence has shown that microbial polyamines are incorporated into host cells to regulate cellular responses. Here, we show that microbial polyamines reinforce colonic epithelial proliferation and regulate macrophage differentiation. Colonisation by wild-type, but not polyamine biosynthesis-deficient, Escherichia coli in germ-free mice raises intracellular polyamine levels in colonocytes, accelerating epithelial renewal. Commensal bacterium-derived putrescine increases the abundance of anti-inflammatory macrophages in the colon. The bacterial polyamines ameliorate symptoms of dextran sulfate sodium-induced colitis in mice. These effects mainly result from enhanced hypusination of eukaryotic initiation translation factor. We conclude that bacterial putrescine functions as a substrate for symbiotic metabolism and is further absorbed and metabolised by the host, thus helping maintain mucosal homoeostasis in the intestine.
The fate of Si and Fe while nuclear glass alters with steel and clay
Authors: Carriere C. , Dillmann P. , Gin S. , Neff D. , Gentaz L. , Bruguier F. , Monnet I. , Gardes E. , Saheb M. , Foy E. , Nuns N. , Delanoë A. , Dynes J. J. , Michau N. , Martin C. 
Published: April 2021

AbstractThe French concept developed to dispose high-level radioactive waste in geological repository relies on glassy waste forms, isolated from the claystone host rock by steel containers. Understanding interactions between glass and surrounding materials is key for assessing the performance of a such system. Here, isotopically tagged SON68 glass, steel and claystone were studied through an integrated mockup conducted at 50 °C for 2.5 years. Post-mortem analyses were performed from nanometric to millimetric scales using TEM, STXM, ToF-SIMS and SEM techniques. The glass alteration layer consisted of a crystallized Fe-rich smectite mineral, close to nontronite, supporting a dissolution/reprecipitation controlling mechanism for glass alteration. The mean glass dissolution rate ranged between 1.6 × 10−2 g m−2 d−1to 3.0 × 10−2g m−2 d−1, a value only 3–5 times lower than the initial dissolution rate. Thermodynamic calculations highlighted a competition between nontronite and protective gel, explaining why in the present conditions the formation of a protective layer is prevented.
A food web including parasites for kelp forests of the Santa Barbara Channel, California
Authors: Morton Dana N. , Antonino Cristiana Y. , Broughton Farallon J. , Dykman Lauren N. , Kuris Armand M. , Lafferty Kevin D. 
Published: April 2021

AbstractWe built a high-resolution topological food web for the kelp forests of the Santa Barbara Channel, California, USA that includes parasites and significantly improves resolution compared to previous webs. The 1,098 nodes and 21,956 links in the web describe an economically, socially, and ecologically vital system. Nodes are broken into life-stages, with 549 free-living life-stages (492 species from 21 Phyla) and 549 parasitic life-stages (450 species from 10 Phyla). Links represent three kinds of trophic interactions, with 9,352 predator-prey links, 2,733 parasite-host links and 9,871 predator-parasite links. All decisions for including nodes and links are documented, and extensive metadata in the node list allows users to filter the node list to suit their research questions. The kelp-forest food web is more species-rich than any other published food web with parasites, and it has the largest proportion of parasites. Our food web may be used to predict how kelp forests may respond to change, will advance our understanding of parasites in ecosystems, and fosters development of theory that incorporates large networks.
Agro-ecological landuse transformation in oasis systems of Al Jabal Al Akhdar, northern Oman
Authors: Buerkert Andreas , Dix Bryan Adam , Al Rawahi Mohamed Nasser , Schlecht Eva 
Published: April 2021

AbstractThe millenia-old oasis systems in the Western Hajar Mountains of Northern Oman have received widespread attention as models of sustainable irrigated agriculture in hyperarid Arabia. Given Oman’s rampant urbanization, growing scarcity of water and skilled labour, we quantified chances in water use, land use, and land cover between 2007 and 2018 using a rare time-series approach of detailed GIS-based crop mapping. Results from satellite image analysis and comprehensive ground truthing showed that urban areas grew from 206 ha in 2009 to 230 ha in 2014 and 252 ha in 2018. Throughout this decade, irrigated areas in backyards and front-house gardens of the town, planted largely to tree crops and vegetables, increased from 13.5 to 23.3 ha. Between 2007 and 2018 the actively used area of the studied oasis systems declined by 2.0% and the share of perennial crops without underplanting by 5.1%, while land under agroforestry increased by 2.1% and fallow land by 3.5%. Rising water demand of the sprawling town Sayh Qatanah led to terraces of Al ‘Ayn and Ash Sharayjah now being partly irrigated with treated wastewater which accelerated the abandonment of the old settlement structures. The labour- and water use efficiency-driven transformation of the Al Jabal Al Akhdar oasis agriculture into increasingly market-oriented landuse systems questions its function as example of sustainable, bio-cultural heritage of Arabia.
Cerebral venous steal equation for intracranial segmental perfusion pressure predicts and quantifies reversible intracranial to extracranial flow diversion
Authors: Pranevicius Mindaugas , Pranevicius Henrikas , Pranevicius Osvaldas 
Published: April 2021

AbstractCerebral perfusion is determined by segmental perfusion pressure for the intracranial compartment (SPP), which is lower than cerebral perfusion pressure (CPP) because of extracranial stenosis. We used the Thevenin model of Starling resistors to represent the intra-extra-cranial compartments, with outflow pressures ICP and Pe, to express SPP = Pd–ICP = FFR*CPP–Ge(1 − FFR)(ICP–Pe). Here Pd is intracranial inflow pressure in the circle of Willis, ICP—intracranial pressure; FFR = Pd/Pa is fractional flow reserve (Pd scaled to the systemic pressure Pa), Ge—relative extracranial conductance. The second term (cerebral venous steal) decreases SPP when FFR < 1 and ICP > Pe. We verified the SPP equation in a bench of fluid flow through the collapsible tubes. We estimated Pd, measuring pressure in the intra-extracranial collateral (supraorbital artery) in a volunteer. To manipulate extracranial outflow pressure Pe, we inflated the infraorbital cuff, which led to the Pd increase and directional Doppler flow signal reversal in the supraorbital artery. SPP equation accounts for the hemodynamic effect of inflow stenosis and intra-extracranial flow diversion, and is a more precise perfusion pressure target than CPP for the intracranial compartment. Manipulation of intra-extracranial pressure gradient ICP–Pe can augment intracranial inflow pressure (Pd) and reverse intra-extracranial steal.