bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practical recommendations for therapy and monitoring of mogamulizumab patients in Germany
Authors: Assaf Chalid , Booken Nina , Dippel Edgar , Dobos Gabor , Eich Hans‐Theodor , Klemke Claus‐Detlev , Mitteldorf Christina , Nicolay Jan P. , Theurich Sebastian , Wobser Marion , Stadler Rudolf 
Published: December 2024

SummaryMycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of the heterogeneous group of cutaneous T‐cell lymphomas (CTCL). With the expansion of the biologic treatment landscape, new treatment options have become available in recent years, most notably the C‐C chemokine receptor 4 (CCR4)‐directed monoclonal antibody mogamulizumab. Based on the phase III pivotal trial, mogamulizumab is recommended by the German S2k guidelines for the second‐line treatment of stage IB and above SS and MF, after at least one prior systemic therapy. Since then, new insights on safety and efficacy of mogamulizumab were generated by post hoc analyses and real‐world evidence. A panel of CTCL‐experts discussed available literature and own experiences and developed relevant recommendations on the use of mogamulizumab in clinical practice in Germany. The recommendations cover patient criteria, prior therapies, use of mogamulizumab as monotherapy or combination therapy, management of side effects, duration of therapy, and monitoring schedules. The aim of these clinical recommendations is to support healthcare professionals in their decision‐making and use of mogamulizumab in daily practice.
Endoscopic hemostasis with a self‐assembling peptide gel during endoscopic submucosal dissection and cold‐snare polypectomy in the duodenum: Prospective exploratory study (with video)
Authors: Seya Mayuko , Dohi Osamu , Fukui Hayato , Iwai Naoto , Ochiai Tomoko , Mukai Hiroki , Yamauchi Katsuma , Miyazaki Hajime , Yasuda Takeshi , Yoshida Takuma , Ishida Tsugitaka , Doi Toshifumi , Hirose Ryohei , Inoue Ken , Yoshida Naohisa , Uchiyama Kazuhiko , Ishikawa Takeshi , Takagi Tomohisa , Konishi Hideyuki , Itoh Yoshito 
Published: December 2024

ObjectivesA novel self‐assembling peptide gel (SAPG) was recently developed for hemostasis during endoscopic resection (ER) as an alternative for electrocoagulation and clip placement. Therefore, this exploratory study aimed to evaluate the hemostatic effect of SAPG on bleeding during ER of the duodenum.MethodsPatients with superficial duodenal epithelial tumors who underwent endoscopic submucosal dissection (ESD) or cold‐snare polypectomy (CSP) between June 2022 and October 2023 were enrolled in the study. SAPG was used for hemostasis of the intraprocedural bleeding when spontaneous hemostasis was essential for the continuation of ESD or was not achieved within 30 s after CSP. The primary outcome was a successful hemostatic rate using SAPG.ResultsAmong the included patients, 15 and 8 underwent ESD and CSP, respectively. Forty‐two points of intraoperative bleeding were noted during ESD, of which 39 (92.9%) and 3 (7.1%) were oozing and nonspurting bleedings, respectively. Successful hemostatic rates were 84.6% and 0% in the oozing and nonspurting bleedings, respectively. All nonspurting bleedings were weakened after SAPG use. Of the 70 CSPs, 60 were oozing bleedings (85.7%), which were successfully stopped with SAPG. The median time to hemostasis from SAPG application was 30 s (interquartile range [IQR] 17–40 s) and 25 s (IQR 10–33 s) during ESD and CSP, respectively. No adverse event was observed in any of the cases during the perioperative period.ConclusionSelf‐assembling peptide gel has an acceptable effect of successful hemostasis for intraoperative oozing bleeding during duodenal ESD and CSP.
Complex and Dynamic Gene‐by‐Age and Gene‐by‐Environment Interactions Underlie Functional Morphological Variation in Adaptive Divergence in Arctic Charr (Salvelinus alpinus)
Authors: Ouellet‐Fagg Christine L. , Easton Anne A. , Parsons Kevin J. , Danzmann Roy G. , Ferguson Moira M. 
Published: December 2024

ABSTRACTThe evolution of adaptive phenotypic divergence requires heritable genetic variation. However, it is underappreciated that trait heritability is molded by developmental processes interacting with the environment. We hypothesized that the genetic architecture of divergent functional traits was dependent on age and foraging environment. Thus, we induced plasticity in full‐sib families of Arctic charr (Salvelinus alpinus) morphs from two Icelandic lakes by mimicking prey variation in the wild. We characterized variation in body shape and size at two ages and investigated their genetic architecture with quantitative trait locus (QTL) analysis. Age had a greater effect on body shape than diet in most families, suggesting that development strongly influences phenotypic variation available for selection. Consistent with our hypothesis, multiple QTL were detected for all traits and their location depended on age and diet. Many of the genome‐wide QTL were located within a subset of duplicated chromosomal regions suggesting that ancestral whole genome duplication events have played a role in the genetic control of functional morphological variation in the species. Moreover, the detection of two body shape QTL after controlling for the effects of age provides additional evidence for genetic variation in the plastic response of morphological traits to environmental variation. Thus, functional morphological traits involved in phenotypic divergence are molded by complex genetic interactions with development and environment.
Formation and Finitude: Jean‐Luc Nancy on the Arts as Ontological Doorways
Authors: Higgins Chris 
Published: December 2024

AbstractIn this article Chris Higgins considers two works by Jean‐Luc Nancy — “On Being Singular Plural” and “Why Are There Several Arts and Not Just One?” — in light of the formative task to do justice to the diverse dimensions of oneself given the offerings and demands of the world, a task made difficult by our finitude and the existence of incommensurable goods. While Nancy helps us appreciate the value pluralism animating the (liberal) arts, Higgins argues, Nancy himself shies away from the full implications of his relational ontology. Rather than follow individual arts and artworks into the local habitations they open — accepting the anguish of the arbitrary as the price of our finite but fulsome excursions into the reticulated real — Nancy retreats to the level of a global account (if a lyrical one) of the local.
Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?
Authors: Amacher Simon A. , Baumann Sira M. , Berger Sebastian , Arpagaus Armon , Egli Simon B. , Grzonka Pascale , Kliem Paulina S. C. , Hunziker Sabina , Fisch Urs , Gebhard Caroline E. , Sutter Raoul 
Published: December 2024

AbstractObjectiveLarge language models (LLMs) have recently gained attention for clinical decision‐making and diagnosis. This study evaluates the performance of the recently updated LLM Chat Generative Pre‐Trained Transformer‐4omni (ChatGPT‐4o) in predicting clinical outcomes in patients with status epilepticus and compares its prognostic performance to the Status Epilepticus Severity Score (STESS).MethodsThis retrospective single‐center cohort study was performed at the University Hospital Basel (tertiary academic medical center) from January 2005 to December 2022. It included consecutive adult patients (≥18 years of age) with a diagnosis of status epilepticus. The primary outcome was survival at hospital discharge, and the secondary outcome was return to premorbid neurological function at hospital discharge. The performance characteristics of ChatGPT4‐o (sensitivity, specificity, Youden Index) were evaluated and compared to those of the STESS.ResultsOf 760 patients, 689 patients (90.7%) survived to discharge, and 317 survivors (41.7%) regained their premorbid neurological function at discharge. ChatGPT‐4o predicted survival in 567 of 760 patients (74.6%), of which 45 died. ChatGPT‐4o predicted death in 193 of 760 patients (25.4%), of which 167 survived, resulting in a sensitivity of 75.8% and a specificity of 36.6% (Youden Index 0.12, 95% confidence interval [CI] 0–.28) for predicting survival.ChatGPT‐4o predicted return to premorbid neurologic function in 249 of 760 patients (32.8%), of which 112 did not return to their premorbid neurological function. ChatGPT‐4o predicted no return to premorbid function in 511 of 760 patients (67.2%), of which 180 returned to their premorbid function, resulting in a sensitivity of 43.2% and a specificity of 74.7% (Youden Index .12, 95% CI .08–.28) for predicting return to premorbid neurological function.There was no difference in the prognostic performance of ChatGPT‐4o and the STESS. A second round of prompting did not increase the predictive performance of ChatGPT‐4o.SignificanceChatGPT‐4o unreliably predicts outcomes in patients with status epilepticus. Clinicians should refrain from using ChatGPT‐4o for prognostication in these patients.
Users' Perspectives on the Organization of Rehabilitation Services – A Focus Group Study of User Organization Representatives in Norway
Authors: Søberg Helene Lundgaard , Solvang Per Koren , Andelic Nada , Røe Cecilie , Kirkevold Marit 
Published: December 2024

ABSTRACTBackgroundUser organizations for people with disabilities in Norway work for social equality and participation, and quality of health services for people with disabilities, chronic illnesses and reduced functional capacity. Consideration of the experiences from user representatives is necessary when determining the quality and appropriateness of the rehabilitation services. Rehabilitation services constitute the provision and delivery of intangible products to maintain or improve functioning in individual patients or patient groups. Rehabilitation services can be characterized at the policy (macro), organizational (meso) and individual (micro) levels.ObjectivesTo explore user representatives' perspectives on rehabilitation service provision and organization and how they experience the influence they exert.MethodsFocus group interviews with 14 representatives nominated from 11 user organizations in Norway conducted in 2021. Two online focus groups using a semi‐structured interview guide were conducted. Data analysis was performed according to Braun and Clarke's thematic data analysis.ResultsSix core themes were developed when analyzing the participants' experiences and opinions regarding rehabilitation services. The themes were inter‐connected and addressed perspectives on Access to services, Integration of care, Rehabilitation team, Person centeredness, System and governance and Modes of user representation and contribution.ConclusionThe user representatives revealed tension and complexity influencing the provision and organization of rehabilitation services from individual access to health policy and regulation. Empowering user representatives through training was important to fight tokenism. Filling the role of a user representative at the meso level requires the integration of personal and peer experiences at the micro level, and knowledge of health policy regulations at the macro level.Patient or Public ContributionThe Norwegian Federation of Organisations of Persons with Disabilities recruited user representatives in this study. The user representatives participated in the assessment and discussion of the results of the study. The results were presented for discussion to the User panel at the Research Centre for Habilitation and Rehabilitation Models & Services (CHARM) at the University of Oslo.
Enhancing bone graft efficacy: Antibacterial and osteogenic effects of cerium‐doped biphasic calcium phosphate scaffolds
Authors: Mangaraj Sangita , Swain Subhasmita , Rautray Tapash R. 
Published: December 2024

AbstractBiphasic calcium phosphate powders, composed of hydroxyapatite and β‐tricalcium phosphate, have gained significant interest as excellent substitutes because of their similarity to natural bone mineral and biocompatibility. The objective was to enhance the biological efficacy of biphasic calcium phosphate powder‐based bone graft materials by incorporating trace elements, such as cerium, into the material. In the context of this investigation, a simple wet chemical precipitation technique was established for the purpose of fabricating microporous biphasic calcium phosphate powders scaffolds of cerium followed by gel casting. The 10% Ce in biphasic calcium phosphate powders scaffolds displayed a network of linked microporous structures characterized by consistent micropore size having 250 ± 25 swelling value. There were no observable alterations in the phase composition and microstructure of the scaffolds when cerium was doped. Further, Staphylococcus aureus was used in the polarization‐induced in vitro antibacterial investigation while the survival of bacteria was greatly reduced on polarized surfaces. The biological activity studies revealed that the 10% cerium‐doped biphasic calcium phosphate powders scaffold exhibited superior efficacy in promoting osteogenic differentiation and antibacterial activities compared to its counterpart. Additionally, polarization improves the antibacterial capabilities of these synthetic scaffolds. The stored charge was found to be 4.02 µC.cm−2 at 550°C.
Synergistically reinforced boron carbide ceramics by introduction of Fe and BN
Authors: Wang Shuai , Du Wenxuan , Xing Pengfei , Zhuang Yanxin 
Published: December 2024

AbstractBoron carbide (B4C)‐FeB ceramics and B4C‐FeB‐BN ceramics are prepared via hot pressing with B4C plus different contents of iron (Fe) and B4C plus 5 wt% Fe and different contents of boron nitride (BN), respectively. The phase composition, microstructure, and mechanical properties of the prepared ceramics are studied in detail. The synergistic effect of Fe and BN on hot‐pressed B4C ceramics is discussed. Results indicate that Fe can react with B4C to form FeB, and enhance the densification and mechanical property of B4C ceramics. 5 wt% Fe is the optimal addition amount. Fe and BN can synergistically reinforce B4C ceramics. The ceramics fabricated with B4C‐5 wt% Fe‐4 wt% BN have the optimal comprehensive performance, of which the relative density, hardness, flexural strength, and fracture toughness reach 98.5%, 32.74 GPa, 668.92 MPa, and 4.09 MPa·m1/2, respectively, higher than those of the ceramics fabricated with B4C or with B4C plus Fe. The liquid formed by Fe during sintering enhances the dispersion of BN, which is beneficial to realizing the function of pinning grain boundary and pulling out. The toughening phenomena include intergranular and transgranular fracture, particle pulling out, and bridging.
Four Decades of Sensory Marketing: A Hybrid Review and Future Research Agenda
Authors: Pandey Vaishali , Tripathi Vibhuti 
Published: December 2024

ABSTRACTSensory marketing has garnered significant attention from researchers due to its ability to effectively influence consumer behavior at a subconscious level. However, existing reviews are constrained by either limited scope or methodology, often focusing on specific senses, or domains, or using solely quantitative or qualitative methods. This offers an opportunity to comprehensively synthesize the existing literature and provide direction for future research. Building on this, the present study examines 535 articles assembled, arranged, and assessed using the SPAR‐4‐SLR protocol for a thorough review of sensory marketing literature spanning four decades (1984–2023). The review employs both quantitative and qualitative methods to summarize the diverse research and provide detailed insights from the existing body of literature. The quantitative approach, utilizing keyword co‐occurrence analysis identifies five thematic clusters—sensory cues as communication strategy, sensory experiences in technologically advanced era, taste perception and food consumption, visual perception, and olfactory perception. Furthermore, the qualitative review technique, utilizing the Theory, Context, Characteristics, and Methodology (TCCM) framework reveals prevalent theories and primary research contexts, along with distinctive characteristics and methodologies. Based on these analyses suggestions for potential areas of future research have been stated.
Co‐Producing Employee Engagement Approaches in a Workplace Partnership: A Route to Partial Success in Public Health Workplaces
Authors: Findlay Patricia , Lindsay Colin , Stewart Robert 
Published: December 2024

ABSTRACTWhile employee engagement might enhance staff wellbeing alongside organisational performance, delivering mutual gains can be challenging. This article assesses co‐production as a route to engagement in a public health workplace, and finds that co‐produced engagement strategies and mutual gains outcomes are possible where underpinned by genuinely collaborative organisational governance arrangements.
Ab initio investigation of the thermophysical properties of barium orthovanadate
Authors: Yang Ningxi , Yuan Meilin , Yang Jiali , Ding Xianyong , Wei Haoran , Zhong Chengyong , Li Dongmei , Lv Xuewei , Yu Peng , Jin Xin 
Published: December 2024

AbstractMetal vanadates have garnered widespread attention across various scientific fields due to their exceptional performance. In this work, we investigate the lattice dynamics and thermophysical properties of barium orthovanadate (Ba3V2O8) using first‐principles calculations. We provide reliable thermodynamic data, including entropy and heat capacity across a broad temperature range. The complex crystal structure of Ba3V2O8 leads to strong phonon anharmonicity, which greatly suppresses the contribution of propagative phonons to the lattice thermal conductivity (κL). Moreover, utilizing the unified theory, we find that the significant contribution of coherent phonon transport makes κL exhibit low‐temperature dependence. Notably, coherent phonons along the a‐axis begin to exceed the contribution of propagative phonons at around 400 K and reach a high proportion of 71.9% at 800 K, leading to an anomalous change in κL. This research emphasizes the significant impact of strong anharmonicity and coherent phonon channels on the thermal transport process in Ba3V2O8, providing a crucial perspective for predicting and understanding the thermophysical properties of metal vanadates and contributing to the further regulation of the thermal transport characteristics.
Fabrication and luminescent properties of erbium‐doped Y2O3–MgO and Gd2O3–MgO nanocomposite ceramics
Authors: Balabanov Stanislav , Permin Dmitry , Normani Simone , Belyaev Alexander , Koshkin Vitaliy , Andreev Pavel , Ladenkov Igor , Braud Alain , Camy Patrice , Solé Rosa Maria , Mateos Xavier , Loiko Pavel 
Published: December 2024

AbstractWe report on the fabrication and optical properties of erbium‐doped Y2O3–MgO and Gd2O3–MgO nanocomposite ceramics, with a particular focus on their mid‐infrared emission. The ceramics were fabricated by a self‐propagating high‐temperature synthesis followed by hot pressing. The transmittance of 1.7 mm‐thick 5 at.% Er:Y2O3–MgO and 7 at.% Er:Gd2O3–MgO ceramics at 3 µm amounted to 79.4% and 21.5%, respectively. This difference in transmission, as revealed by microstructural analysis, is due to variation in the distribution of residual pore sizes, while the average grain size is almost the same for both ceramics, being ∼200 nm. The composites exhibited luminescence in the visible, near‐infrared, and mid‐infrared spectral ranges attributed to electronic transitions of Er3+ ions in the cubic sesquioxide phase. Peculiarities in the Raman and luminescence spectra were identified in comparison to single‐phase Er:Y2O3 and Er:Gd2O3 ceramics, which may indicate certain solubility of MgO in the sesquioxide phase of the composites.
Protocols for Postanesthesia Care Unit Handoff and Patient Safety: A Scoping Review
Authors: Martins Fabiana Zerbieri , de Lima Luciana Bjorklund , Trevilato Denilse Damasceno , Hemesath Melissa Prade , de Magalhães Ana Maria Müller 
Published: December 2024

ABSTRACTAimTo map studies that tested an intervention orienting patient transfer to Postanesthesia Care Unit (PACU) and identify outcomes related to care safety.MethodsScoping review guided by recommendations of the JBI Manual and the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis extension for Scoping Reviews (PRISMA‐ScR) guide. The Population, Concept, and Context (PCC) framework was used to develop the research question and consolidate inclusion and exclusion criteria in databases consulted without date parameters. The review protocol was registered in the Open Science Framework.ResultsThe systematic search identified 182 records. After reading their titles and abstracts, 49 studies were read in full. The final sample consisted of 17 texts published between 2013 and 2024. The main elements evaluated in the implementation of interventions to guide patient transfer to the PACU related to patient safety were as follows: increase in the number of transferred information; higher rates of professional satisfaction with teamwork; presence of surgical professionals; questions from the receiver and adequacy to the instrument. Also was identified a pause to monitor the patient before the transfer and reduction of omitting information, interruptions, distractions, task errors, hypoxemia, nausea, vomiting and excessive pain.ConclusionsThe variables evaluated after the interventions to promote a structured patient transfer to the PACU have the potential to guide the development of quality assessment indicators and contribute to the promotion of a safety culture in institutions.ImpactConsidering the constant increase in complexity and demand for perioperative care, the investigation of patient transfer processes to the PACU can provide support for the management of surgical practices and contribute to improving patient safety and the experience of the health professionals involved.Patient or Public ContributionNo patient or public contribution.OSF registration: https://doi.org/10.17605/OSF.IO/M2FYN.
Mindsets of Parenting Ability: Coping With Challenges and Engaging in Parenting
Authors: Burnette Jeni L. , Becker Whitney , Hoyt Crystal L. , Lipsey Nikolette P. 
Published: December 2024

ABSTRACTParenting can bring both joy and stress. Identifying factors that foster greater engagement and enjoyment while also helping parents cope with inevitable stressors is critical for healthy child development and parental wellbeing. In the current work, we build on growth mindset theory to explore individual differences in beliefs about the changeable nature of parenting ability. Specifically, across three correlational studies (N = 1170), we investigated if growth mindsets about parenting related to coping in the wake of parenting setbacks and to parental engagement. Growth mindsets predicted more positive expectations and less avoidant coping after parenting challenges, and these processes, and growth mindsets, correlated with parental engagement. Across the three studies, average links between growth mindsets and the two primary outcomes of interest—avoidant coping and engagement—were r = −0.31 and r = 0.20, respectively.