bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tunable Circularly Polarized Luminescent Supramolecular Systems: Approaches and Applications
Authors: Chen Xu‐Man , Zhang Shu , Chen Xiao , Li Quan 
Published: December 2021

AbstractCircularly polarized luminescence is an important optical property that combines chirality and luminescence in molecular and supramolecular systems. Recently, tunable circularly polarized luminescent (CPL) supramolecular systems with stimuli‐ responsiveness have emerged as promising materials for applications including smart displays and optical data storage. Owing to the adaptive capacity of supramolecular systems, intelligent CPL materials have been developed by incorporating chiral and achiral building blocks, thus expanding the available approaches for realizing CPL materials. Non‐covalent interactions in supramolecular systems offer various opportunities for regulating CPL emission using stimuli such as light, temperature, pH, mechanical force, electric field, and magnetic field. Several media modulation methods such as host‐guest complexation, solvent effect, and gelation have also been introduced to realize tunable CPL emission by ensuring effective chirality transfer, charge transfer, and energy transfer. Herein, recent progress in supramolecular CPL systems regulated using diverse stimuli is presented, and corresponding mechanisms and potential applications are briefly highlighted.
A novel drug delivery system using acyclovir nanofiber patch for topical treatment of recurrent herpes labialis: A randomized clinical trial
Authors: Golestannejad Zahra , Khozeimeh Faezeh , Mehrasa Mohammad , Mirzaeei Shahla , Sarfaraz Dorna 
Published: December 2021

AbstractObjectivesTopical treatment with acyclovir cream has shown low efficacy in recent studies. Nano drug delivery systems, have received much attention in recent decades. The aim of this study was to compare the efficacy of acyclovir nanofiber patch with acyclovir cream.Material and MethodsIn this double‐blind three‐armed randomized clinical trial, a total of 60 patients with recurrent labial herpes, were randomly divided into three groups, each consisting of 20. The patients in the first, second, and third groups were treated with acyclovir nanofiber patch, placebo nanofiber patch, and acyclovir cream, respectively. A numerical scale was used by the patients to record the self‐reported symptoms. Symptoms score, crusting time and healing time were assessed by the clinician. Kruskal‐Wallis test was used to compare the symptoms between the three groups, a survival test was also performed to evaluate the crusting and healing time. Data were analyzed in SPSS V22 at P‐value < 0.05.ResultsThe mean scores of symptoms at baseline were 1.6, 1.5, and 1.4 in the first, second, and third groups, respectively. The symptoms were not significantly different between the three groups on different treatment days. The mean crusting time was 2.3, 2.4, and 2.6 days in the three groups, and the mean healing time was 7.4, 7.2, and 7.7 days, respectively. Crusting time and healing time were not significantly different between the three groups.ConclusionsAcyclovir nanofiber patches are recommended for accelerating symptom relief in recurrent labial herpes, however, they are not effective in shortening the crusting or healing time.Clinical Trial Registration Number: IRCT20141124020073N2.Registered in: Iranian Registry of Clinical Trials (www.irct.ir).
Responsible Leadership Competencies in leaders around the world: Assessing stakeholder engagement, ethics and values, systems thinking and innovation competencies in leaders around the world
Authors: Muff Katrin , Delacoste Coralie , Dyllick Thomas 
Published: December 2021

AbstractThis article builds on the competency assessment of responsible leadership (CARL) developed by Muff et al. (Corporate Social Responsibility and Environmental Management Journal, 2020, 27, 2254–2274) and assesses the data collected from a sample of 9’566 participants across 122 countries in the timeframe. The analysis reveals interesting, sometimes counter‐intuitive, insights that advance current thinking on the topic of responsible leadership (RL). As such “self‐awareness” emerges as the central element in RL. There is evidence suggesting that higher education leads to a better RL performance. Interestingly, the study highlights that participants in the African region outperform other participants. In addition, a sustainability affinity does not lead to a higher RL score, and CEOs from sustainability‐conscious organizations do not perform better than their demographic peers. The data suggests that executives do not increase their RL performance after a leadership development course, while undergraduate students do. The paper explores some answers while acknowledging that more research is needed to understand how these insights inform leadership education.
C‐reactive protein flare‐response predicts long‐term efficacy to first‐line anti‐PD‐1‐based combination therapy in metastatic renal cell carcinoma
Authors: Klümper Niklas , Schmucker Philipp , Hahn Oliver , Höh Benedikt , Mattigk Angelika , Banek Severine , Ellinger Jörg , Heinzelbecker Julia , Sikic Danijel , Eckstein Markus , Strauß Arne , Zengerling Friedemann , Hölzel Michael , Zeuschner Philip , Kalogirou Charis 
Published: December 2021

AbstractObjectivesImmune checkpoint blockade (IO) has revolutionised the treatment of metastatic renal cell carcinoma (mRCC). Early C‐reactive protein (CRP) kinetics, especially the recently introduced CRP flare‐response phenomenon, has shown promising results to predict IO efficacy in mRCC, but has only been studied in second line or later. Here, we aimed to validate the predictive value of early CRP kinetics for 1st‐line treatment of mRCC with αPD‐1 plus either αCTLA‐4 (IO+IO) or tyrosine kinase inhibitor (IO+TKI).MethodsIn this multicentre retrospective study, we investigated the predictive potential of early CRP kinetics during 1st‐line IO therapy. Ninety‐five patients with mRCC from six tertiary referral centres with either IO+IO (N = 59) or IO+TKI (N = 36) were included. Patients were classified as CRP flare‐responders, CRP responders or non‐CRP responders as previously described, and their oncological outcome was compared.ResultsOur data validate the predictive potential of early CRP kinetics in 1st‐line immunotherapy in mRCC. CRP responders, especially CRP flare‐responders, had significantly prolonged progression‐free survival (PFS) compared with non‐CRP responders (median PFS: CRP flare‐responder: 19.2 months vs. responders: 16.2 vs. non‐CRP responders: 5.6, P < 0.001). In both the IO+IO and IO+TKI subgroups, early CRP kinetics remained significantly associated with improved PFS. CRP flare‐response was also associated with long‐term response ≥ 12 months.ConclusionsEarly CRP kinetics appears to be a low‐cost and easy‐to‐implement on‐treatment biomarker to predict response to 1st‐line IO combination therapy. It has potential to optimise therapy monitoring and might represent a new standard of care biomarker for immunotherapy in mRCC.
Development and assessment of a brief screening tool for psychosis in dementia
Authors: Cummings Jeffrey L. , Ismail Zahinoor , Dickerson Bradford C. , Ballard Clive , Grossberg George , McEvoy Bradley , Foff Erin , Atri Alireza 
Published: December 2021

AbstractIntroductionHallucinations and delusions (H+D) are common in dementia, but screening for these symptoms—especially in busy clinical practices—is challenging.MethodsSix subject matter experts developed the DRP3™ screen, a novel valid tool to detect H+D in dementia, assessed its content validity through alignment with DRP reference assessments (Scale for the Assessment of Positive Symptoms‐Hallucinations + Delusions, Neuropsychiatric Inventory‐Questionnaire, International Psychogeriatric Association Criteria), and retrospectively investigated its ability to detect H+D in HARMONY trial (NCT03325556) enrollees.ResultsAll items from three reference assessments demonstrated significant agreement with the DRP3 screen among raters (P < .0001). Retrospectively applying the DRP3 screen to HARMONY identified all (N = 392) trial enrollees.DiscussionThe DRP3 screen, comprising three yes/no questions, is a content‐valid tool for detecting H+D in dementia that aligned with current reference assessments and successfully identified trial participants when retrospectively applied to a completed trial. Within busy practice constraints, the DRP3 screen provides a brief tool for sensitive detection of H+D in patients with dementia.
Carbon Dots Derived from Waste Psidium Guajava Leaves for Electrocatalytic Sensing of Chlorpyrifos
Authors: Dash Smruti Ranjan , Bag Subhendu Sekhar , Golder Animes Kumar 
Published: December 2021

AbstractCarbon dots (CDs) modified GCE was used for the electrochemical sensing of Chlorpyrifos (CHL). The hydrothermal synthesis (200 °C for 10 h) produced CDs of 3.7 nm using Psidium guajava leaves. Square wave voltammetry was employed for the determination of CHL and the electrokinetic parameters. The reduction of CHL involved an irreversible two‐electron process with heterogeneous reaction rate (k°) and formal potential (E°) of 1.21 s−1 and −1.34 V respectively. The modified GCEs exhibited good repeatability (RSD 4.7 %), reproducibility (RSD 1.17 %), and sensitivity (1.30 mA μM−1 cm−2). The detection limit and linear ranges were 1.5 nM and 0.01–1 μM, respectively. Electrochemical sensing of CHL was comparable with the HPLC (∼5 % variation).
In‐plane/out‐of‐plane interaction of strong masonry infills: From cyclic tests to out‐of‐plane verifications
Authors: Morandi Paolo , Hak Sanja , Milanesi Riccardo R. , Magenes Guido 
Published: December 2021

AbstractThe construction of RC frame structures with masonry infills is part of the traditional building practice in many European countries and worldwide. Several studies have been recently conducted to improve further the understanding of the seismic response of masonry infills, which are mainly focused on weak/slender clay masonry panels representing a common typology of the past, whereas very limited research has been devoted to stronger/thicker masonry infills, which nowadays are being adopted with increasing frequency in newly designed RC structures for their excellent thermal and acoustic performance. In order to fill this gap, within a systematic experimental and numerical research program, the in‐plane and out‐of‐plane experimental response of ‘strong’ masonry infills has been investigated at the Eucentre and the University of Pavia. In particular, this paper presents the framework and discusses the results of out‐of‐plane static cyclic tests on full‐scale, single‐storey, single‐bay RC frame specimens infilled with 35 cm thick tongue and groove clay unit walls, the related damage propagation and the failure mechanisms. The in‐plane/out‐of‐plane experimental interaction evaluated in terms of stiffness and strength reduction and period increase in function of previous in‐plane damage is also introduced, with the aim of providing a simplified out‐of‐plane strength verification within the European codified design procedures.
Understanding the effects of rhythmic coordination on children's prosocial behaviours
Authors: Wan Yingjia , Zhu Liqi 
Published: December 2021

AbstractJoint rhythmic activities are known to be able to enhance prosociality in both adults and children. A large body of research shows that rhythmic coordination could promote bonding and increase prosocial behaviours such as helping, cooperating and sharing, suggesting that rhythmic interaction could be an effective tool to promote children's prosocial development. Nevertheless, the mechanism underlying the prosocial effects of rhythmic activities remains under debate. In this brief paper, we review a selection of literature that examines this mechanism from the perspective of interpersonal coordination, discussing the roles mimicry, synchrony, coordination and shared intentionality play in the process. In the end, we provide recommendations for future work to advance our understanding of the effects of rhythmic interaction on prosociality and future practice to improve children's prosocial development.
The chorioallantoic membrane: A novel approach to extrapolate data from a well‐established method
Authors: Maugeri Alessandro , Lombardo Giovanni E. , Navarra Michele , Cirmi Santa , Rapisarda Antonio 
Published: December 2021

AbstractThe chorioallantoic membrane (CAM) of the chicken embryo is a highly vascularized extra‐embryonic structure that has been widely used as an in vivo model for the evaluation of angiogenesis. This study was designed to optimize data extrapolation from the most exploited experimental protocol to improve its efficiency and the reliability of the obtainable results. In our study, we followed the most common procedure for CAM assay, employing retinoic acid and vascular endothelial growth factor as standards. CAMs were photographed at t0, t24, and t48; then, the main parameters of the predefined vascular network/area were evaluated. Subsequently, their variations in each CAM were calculated comparing them within the same CAM over the course of the whole treatment (t24 and t48), also comparing the treated CAMs respect to the untreated ones. Thus, we provide a novel approach aimed at extrapolating data from CAM assay that allows to (i) have a greater reliability and richness of data; (ii) better estimate the potential pro‐ and anti‐angiogenic activity of new candidate drugs; (iii) save both eggs and time for the experiments.
Respiratory rate monitoring in healthy volunteers by central photoplethysmography compared to capnography
Authors: Henricson Joakim , Glasin Joakim , Rindebratt Sandra , Wilhelms Daniel 
Published: December 2021

AbstractMonitoring of respiration is a central task in clinical medicine, crucial to patient safety. Despite the uncontroversial role of altered respiratory frequency as an important sign of impending or manifest deterioration, reliable measurement methods are mostly lacking outside of intensive care units and operating theaters. Photoplethysmography targeting the central blood circulation in the sternum could offer accurate and inexpensive monitoring of respiration. Changes in blood flow related to the different parts of the respiratory cycle are used to identify the respiratory pattern. The aim of this observational study was to compare photoplethysmography at the sternum to standard capnography in healthy volunteers. Bland Altman analysis showed good agreement (bias −0.21, SD 1.6, 95% limits of agreement −3.4 to 2.9) in respiratory rate values. Photoplethysmography provided high‐quality measurements of respiratory rate comparable to capnographic measurements. This suggests that photoplethysmography may become a precise, cost‐effective alternative for respiratory monitoring.
Improving the resilience of SMEs in times of crisis: The impact of mobile money amid Covid‐19 in Zambia
Authors: Nan Wenxiu (Vince) , Park Minseok 
Published: December 2021

AbstractThis study investigates the impact of mobile money (MM) on SMEs' resilience and the associated business outcome in developing countries amid Covid‐19. Despite the potential of MM to improve SMEs' resilience, little evidence has been documented. Using Enterprise Survey data in Zambia, we show that SMEs are more likely than large firms to experience catastrophic sales decline, reflecting their inherent vulnerability. Further analysis reveals that this unfavourable effect can be effectively counteracted when SMEs incorporate MM into daily business. An important policy implication is that the use of digital technologies should be a key element of policy responses to Covid‐19.
Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency
Authors: Jiang Huafang , Alahmad Ahmad , Fu Song , Fu Xiaoling , Liu Zhimei , Han Xiaodi , Li Lanlan , Song Tianyu , Xu Manting , Liu Shanshan , Wang Junling , Albash Buthaina , Alaqeel Ahmad , Catalina Vasilescu , Prokisch Holger , Taylor Robert W. , McFarland Robert , Fang Fang 
Published: December 2021

AbstractPyruvate, the end product of glycolysis, is a key metabolic molecule enabling mitochondrial adenosine triphosphate synthesis and takes part in multiple biosynthetic pathways within mitochondria. The mitochondrial pyruvate carrier (MPC) plays a vital role in transporting pyruvate from the cytosol into the organelle. In humans, MPC is a hetero‐oligomeric complex formed by the MPC1 and MPC2 paralogs that are both necessary to stabilize each other and form a functional MPC. MPC deficiency (OMIM#614741) due to pathogenic MPC1 variants is a rare autosomal recessive disease involving developmental delay, microcephaly, growth failure, and increased serum lactate and pyruvate. To date, two MPC1 variants in four cases have been reported, though only one with a detailed clinical description. Herein, we report three novel pathogenic MPC1 variants in six patients from three unrelated families, identified within European, Kuwaiti, and Chinese mitochondrial disease patient cohorts, one of whom presented as a Leigh‐like syndrome. Functional analysis in primary fibroblasts from the patients revealed decreased expression of MPC1 and MPC2. We rescued pyruvate‐driven oxygen consumption rate in patient's fibroblasts by reconstituting with wild‐type MPC1. Complementing homozygous MPC1 mutant cDNA with CRISPR‐deleted MPC1 C2C12 cells verified the mechanism of variants: unstable MPC complex or ablated pyruvate uptake activity. Furthermore, we showed that glutamine and beta‐hydroxybutyrate were alternative substrates to maintain mitochondrial respiration when cells lack pyruvate. In conclusion, we expand the clinical phenotypes and genotypes associated with MPC deficiency, with our studies revealing glutamine as a potential therapy for MPC deficiency.
Identification of an IRES within the coding region of the structural protein of human rhinovirus 16
Authors: Shi Bingtian , Song Qinqin , Luo Xiaonuan , Song Juan , Xia Dong , Xia Zhiqiang , Liu Mi , Wang Wenjun , Wang Ruifang , Du Haijun , Wei Qiang , Han Jun 
Published: December 2021

AbstractAs an alternative mechanism for cap‐dependent (m7GpppN) translation, internal ribosome entry site (IRES)‐dependent translation has been observed in the 5′ untranslated regions (5′ UTR) and coding regions of a number of viral and eukaryotic mRNAs. In this study, a series of 5′ terminal truncated structural protein genes that were fused with GFP was used to screen for potential IRESs, and IRESs were identified using a bicistronic luciferase vector or GFP expression vector possessing a hairpin structure. Our results revealed that a putative IRES was located between nt 1982 and 2281 in the VP3 coding region of the human rhinovirus 16 (HRV16) genomes. We also demonstrated that effective IRES‐initiated protein expression in vitro did not occur through splicing sites or cryptic promoters. We confirmed that thapsigargin (TG), an inducer of endoplasmic reticulum stress (ERS), facilitated increased IRES activity in a dose‐dependent manner. Additionally, the secondary structure of the IRES was predicted online using the RNAfold web server.
Prediction of Oxygen Desaturation by Using Sound Data From a Noncontact Device: A Proof‐of‐Concept Study
Authors: Kim Jeong‐Whun , Shin Jaeyoung , Lee Kyogu , Won Tae‐Bin , Rhee Chae‐Seo , Cho Sung‐Woo 
Published: December 2021

Objectives/HypothesisPrediction of the apnea‐hypopnea index (AHI) from breathing sounds during sleep could be used to prescreen for obstructive sleep apnea (OSA). In addition, the oxygen desaturation index (ODI) is a known risk factor for developing cardiovascular disease in OSA patients. This study focused on estimation of ODI from a noncontact manner from sleep breathing sounds.Study DesignRetrospective study.MethodsPatients who visited the sleep center due to snoring or sleep apnea underwent polysomnography in lab overnight. Sound recordings were made during polysomnography using a microphone. After noise reduction, the sound data were segmented into 5 seconds windows and features were extracted. Binary classification and regression analyses were performed to estimate the ODI during sleep (model 1). This was re‐tested after inclusion of body mass index (BMI) and age as additional features (model 2: BMI only, model 3: BMI and age).ResultsWe included 116 patients. The mean age and AHI of all patients were 50.4 ± 16.7 years and 23.0 ± 24.0 events/hr. In binary classification, for ODI cutoff values of 5, 15, and 30 events/hr, the areas under the curve were 0.88, 0.93, 0.91, respectively, and accuracies were 85.34, 86.21, and 87.07, respectively. In regression analysis, the correlation coefficient and mean absolute error were 0.80 and 9.60 events/hr, respectively. In models 2 and 3, the correlation coefficient and mean absolute error were 0.82, 9.44 events/hr and 0.81, 9.6 events/hr, respectively.ConclusionPrediction of ODI from sleep sound seems to be feasible. Additional clinical feature such as BMI may increase overall predictability.Level of Evidence4 Laryngoscope, 132:901–905, 2022
Nanosized molybdenum disulfide on surface‐modified carbon material as lubricating oil additive for friction‐reduction and anti‐wear
Authors: Su Huaigang , Li Chencan , Jiang Cheng , Wang Yanan , Wang Xiaobo , Gong Kuiliang , Lou Wenjing 
Published: December 2021

AbstractFor the first time, nanosized molybdenum disulfide (MoS2) nanoparticles (NPs) were grown on the surface of poly(ethylene glycol)‐polydopamine‐modified reduction graphene oxide) nanosheets (rGO‐PDA‐PEG). The obtained rGO‐PDA‐PEG@MoS2 nanocomposites exhibits excellent dispersion in polyalkylene glycol (PAG) synthetic oil and outperforms GO and MoS2 NPs as additives in terms of friction reduction and wear resistance at elevated temperature. The superior tribological behaviour of rGO‐PDA‐PEG@MoS2 might be beneficial to the synergistic effect between MoS2 and rGO.
Transparent Soft Electrothermal Actuators with Integrated Cu Nanowire Heater for Soft Robotics
Authors: Chang Chunlei , Zhao Le , Song Zichen , Zhou Yan , Yu Shihui 
Published: December 2021

AbstractSoft actuators with high flexibility have received widespread attention. Here, a transparent electrothermal soft actuator is designed and manufactured via sandwiched copper nanowires (Cu NWs) between two kinds of flexible substrates with different thermal expansion characteristics (polyethylene‐terephthalate (PET) and low‐density polyethylene (LDPE)). In order to improve bending characteristics of the soft actuator, heating performance of heaters with different widths is studied, and the bending characteristics of strain gauges under different voltages are also studied. The fabricated soft actuator can produce a bend of 90° and provide about 1 mN of force at a low voltage of 6 V. The application of this type of soft actuator is demonstrated toward biomimetic robotics, a two‐finger flexible transparent gripper is designed, where two soft actuators are utilized to simulate the movements of human fingers and realizes the operation of picking and placing fine objects. In addition, the topography of the object can be feasibly observed during clamping process of the soft actuator with certain light transmittance, which is favorable for the soft gripper application.
Coupling Kinetic Modelling with SAOS and LAOS Rheology of Poly(n‐butyl acrylate)
Authors: Grotian genannt Klages Hannah , Ermis Nihal , Luinstra Gerrit Albert , Zentel Kristina Maria 
Published: December 2021

AbstractA kinetic model based on fundamentals of radical polymerization and literature known rate parameters for the polymerization of n‐butyl acrylate is validated against molecular analysis and rheological data. The model is used to predict conversion, molar mass distribution, and branching densities in form of short and long chain branching. Rheological measurements of synthesized model polymers are evaluated along the Carreau‐Yasuda and Van Gurp‐Palmen presentations, allowing to detect small differences in the degree of long chain branching. Contributions of anharmonics to viscoelastic response in large amplitude oscillations are small and differences between the products are dominated by the differences in molar mass.