bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chondromalacia patellae: current options and emerging cell therapies
Authors: Zheng Weitao , Li Hanluo , Hu Kanghong , Li Liming , Bei Mingjian 
Published: July 2021

AbstractChondromalacia patellae (CMP), also known as runner’s knee, typically occurs in young patients, which is characterized by anterior knee pain (AKP) that is associated with visible changes in patellar cartilage. The initial pathological changes include cartilage softening, swelling, and edema. CMP is caused by several factors, including trauma, increased cartilage vulnerability, patellofemoral instability, bony anatomic variations, abnormal patellar kinematics, and occupation hazards. CMP may be reversible or may progress to develop patellofemoral osteoarthritis. Quadriceps wasting, patellofemoral crepitus, and effusion are obvious clinical indications. Additionally, radiological examinations are also necessary for diagnosis. Magnetic resonance imaging (MRI) is a non-invasive diagnostic method, which holds a promise in having the unique ability to potentially identify cartilage lesions. Modalities are conventionally proposed to treat cartilage lesions in the PF joint, but none have emerged as a gold standard, neither to alleviated symptoms and function nor to prevent OA degeneration. Recently, researchers have been focused on cartilage-targeted therapy. Various efforts including cell therapy and tissue emerge for cartilage regeneration exhibit as the promising regime, especially in the application of mesenchymal stem cells (MSCs). Intra-articular injections of variously sourced MSC are found safe and beneficial for treating CMP with improved clinical parameters, less invasiveness, symptomatic relief, and reduced inflammation. The mechanism of MSC injection remains further clinical investigation and is tremendously promising for CMP treatment. In this short review, etiology, MRI diagnosis, and treatment in CMP, especially the treatment of the cell-based therapies, are reviewed.
Model order reduction for gas and energy networks
Authors: Himpe Christian , Grundel Sara , Benner Peter 
Published: July 2021

AbstractTo counter the volatile nature of renewable energy sources, gas networks take a vital role. But, to ensure fulfillment of contracts under these circumstances, a vast number of possible scenarios, incorporating uncertain supply and demand, has to be simulated ahead of time. This many-query gas network simulation task can be accelerated by model reduction, yet, large-scale, nonlinear, parametric, hyperbolic partial differential(-algebraic) equation systems, modeling natural gas transport, are a challenging application for model order reduction algorithms.For this industrial application, we bring together the scientific computing topics of: mathematical modeling of gas transport networks, numerical simulation of hyperbolic partial differential equation, and parametric model reduction for nonlinear systems. This research resulted in the (Model Order Reduction for Gas and Energy Networks) software platform, which enables modular testing of various combinations of models, solvers, and model reduction methods. In this work we present the theoretical background on systemic modeling and structured, data-driven, system-theoretic model reduction for gas networks, as well as the implementation of and associated numerical experiments testing model reduction adapted to gas network models.
Utilization of Completely Recycled Fine Aggregate for Preparation of Lightweight Concrete Partition Panels
Authors: Yang Yibo , Chen Baixi , Zeng Weizhen , Li Yanjun , Chen Qiaohui , Guo Wenying , Wang Hengchang , Chen Yingqin 
Published: July 2021

AbstractTo reduce the cost of lightweight concrete (LWC) partition panels and to address recycling concrete waste, this work utilized completely recycled fine aggregate (CRFA) to replace the natural fine aggregate and ceramsite in the preparation of LWC and LWC partition panels. To this end, an autoclave-free curing process and an air-entraining agent were used to prepare the CRFA-LWC. The workability, compressive strength, drying shrinkage, and pore structure of the CRFA-LWC and the performance of the CRFA-LWC partition panels were then investigated. The results show that the optimal ratio of the CRFA to the cement is 2.2 for the lightweight concrete, and the optimal panel cross section is a rounded rectangular one. All the pores in the CRFA-LWC have a diameter of smaller than 0.17 mm, and the diameter of 89% of them is less than 0.05 mm. In order to satisfy the drying shrinkage requirements stipulated by Chinese code JC/T 169-2016, the CRFA-LWC should be cured for at least 10 days. The economic analysis concludes that the material cost of CRFA-LWC is 40% lower than that of the autoclaved ceramsite concrete. In addition, utilizing CRFA in lightweight concrete can ease the shortage of natural aggregate.
Influence of learning and internship satisfaction on students’ intentions to stay at their current jobs: survey of students participating in Taiwan’s dual education system
Authors: Liu Louis Chih-hung 
Published: July 2021

AbstractWe investigated the effectiveness of Taiwan’s dual education system, referred to as the dual system of vocational training policy (DSVTP) program. By surveying 722 randomly selected respondents participating in the DSVTP program, we examined the effects of students’ satisfaction with their learning and internship in the program on their intentions to stay at their current jobs. We employed structural equation modeling to analyze the associations among factors. Our empirical results revealed positive correlations between learning satisfaction, job involvement, dual system satisfaction, and intentions to stay at the current job. These empirical results also suggested that students participating DSVTP are largely satisfied with this program and would promote them to stay at current job, which in turn helps to alleviate youth unemployment. On the basis of the statistical analysis results, policy implications that could serve as a reference in future reforms of the DSVTP in Taiwan are also discussed.
Pharmacy preparedness in handling COVID-19 pandemic: a sharing experience from a Malaysian tertiary hospital
Authors: Thong Kah Shuen , Selvaratanam Manimegahlai , Tan Chiew Ping , Cheah Meng Fei , Oh Hoey Lin , Lee Pooi Mun , Chew Chii-Chii , Chang Chee-Tao , Lee Jason Choong Yin 
Published: July 2021

AbstractThis commentary shares the experience of a hospital pharmacy department in providing healthcare services during the COVID-19 outbreak in Malaysia. During this pandemic, the medication delivery system is redesigned to minimize contact among patients and the health care providers. Also, the remote medication monitoring system was implemented to deliver pharmaceutical care for inpatients. Communication technology was used to assist the pharmacist in medication counseling. QR codes to access videos demonstrating the use of devices were made available for patients. Pharmacists were also tasked with the procurement of personal protective equipment and medications needed requiring special approval from the Ministry of Health.
Review on self-regulated learning in smart learning environment
Authors: Gambo Yusufu , Shakir Muhammad Zeeshan 
Published: July 2021

AbstractDespite the increasing use of the self-regulated learning process in the smart learning environment, understanding the concepts from a theoretical perspective and empirical evidence are limited. This study used a systematic review to explore models, design tools, support approaches, and empirical research on the self-regulated learning process in the smart learning environment. This review revealed that there is an increasing body of literature from 2012 to 2020. The analysis shows that self-regulated learning is a critical factor influencing a smart learning environment’s learning process. The self-regulated learning components, including motivation, cognitive, metacognitive, self-efficiency, and metacognitive components, are most cited in the literature. Furthermore, self-regulated strategies such as goal setting, helping-seeking, time management, and self-evaluation have been founded to be frequently supported in the literature. Besides, limited theoretical models are designed to support the self-regulated learning process in a smart learning environment. Furthermore, most evaluations of the self-regulated learning process in smart learning environment are quantitative methods with limited mixed methods. The design tools such as visualization, learning agent, social comparison, and recommendation are frequently used to motivate students’ learning engagement and performance. Finally, the paper presents our conclusion and future directions supporting the self-regulated learning process in the smart learning environment.
A cross sectional study of non-medical use of prescription opioids and suicidal behaviors among adolescents
Authors: Wright Nate , Ramirez Marizen R. 
Published: July 2021

Abstract
Background
Non-medical use of prescription opioids (NMUPO), defined as taking an opioid in a manner or dose other than prescribed, taking someone else’s, or for the feelings that it produces, has been reported by 5 to 20% of adolescents, and is associated with a two fold increase in suicidal behaviors among adolescents. Adolescents with long-term health problems (LTHP) have poorer mental health and may seek NMUPO for pain relief that is not obtained through standard care. For this study, we measured the association between NMUPO and suicidal behaviors, and further assessed effect modification by LTHP hypothesizing the association between NMUPO and suicidal behaviors was stronger for adolescents with LTHP.

Findings
For students with LTHP, 13.5% reported suicide ideation, while 8.0% of students without LTHP reported suicide ideation. For suicide attempt, 4.4% of students with LTHP reported a suicide attempt, while 2.1% of students without LTHP reported a suicide attempt. The proportion of students who reported suicide ideation and attempts increased with higher occasions of NMUPO. Adjusted logistic regression models found increased odds of suicide ideation (OR (95% CI): 1–5 occasions: 2.3 (2.0–2.6); > 6 occasions: 2.7 (2.2–3.8)) and suicide attempts (OR (95% CI): 1–5 occasions: 3.2 (2.7–3.7); > 6 occasions: 4.1 (3.1–5.3)) for students who reported NMUPO. An interaction term for NMUPO and LTHP was then added to the models. Effect modification was not present on the multiplicative scale. On the additive scale, evidence of effect modification was observed: higher risk was indicated for students with LTHP versus no LTHP for both suicide ideation (Predicted risk (95%CI): > 6 occasions NMUPO, LTHP: 0.24 (0.18–0.29); No LTHP: 0.16 (0.13–0.18)) and attempt (Predicted risk (95%CI): 1–5 occasions NMUPO, LTHP: 0.08 (0.07–0.10); No LTHP: 0.05 (0.05–0.06); > 6 occasions NMUPO, LTHP: 0.11 (0.07–0.15); No LTHP: 0.06 (0.05–0.08)).

Conclusions
The results affirmed that NMUPO is associated with suicidal behaviors among adolescents. A pattern also emerged of higher risk of suicidal behaviors for those with LTHP who reported NMUPO. Areas of further inquiry should explore chronic medical or pain conditions as possible modifying pathways that could exacerbate the effects of NMUPO on suicidal behaviors specific to an adolescent population.
Technical note: rectangular femoral tunnel for anterior cruciate ligament reconstruction using a new ultrasonic device: a feasibility study
Authors: Seil Romain , Mouton Caroline , Jacquet Christophe 
Published: July 2021

Abstract
Purpose
The goal of this preliminary report was to show the use of novel Ultrasound (US) technology for anterior cruciate ligament (ACL) reconstruction surgery and evaluate its feasibility for the creation of a rectangular femoral bone tunnel during an arthroscopic procedure in a human cadaver model.

Methods
Two fresh frozen human cadaver knees were prepared for arthroscopic rectangular femoral tunnel completion using a prototype US device (OLYMPUS EUROPA SE & CO. KG). The desired rectangular femoral tunnel was intended to be located in the femoral anatomical ACL footprint. Its tunnel aperture was planned at 10 × 5 mm and a depth of 20 mm should be achieved. For one knee, the rectangular femoral tunnel was realized without a specific cutting guide and for the other with a 10 × 5 mm guide. One experienced orthopedic surgeon performed the two procedures consecutively. The time for femoral tunnel completion was evaluated. CT scans with subsequent three-dimensional image reconstructions were performed in order to evaluate tunnel placement and configuration.

Results
In the two human cadaver models the two 10 × 5x20mm rectangular femoral tunnels were successfully completed and located in the femoral anatomical ACL footprint without adverse events. The time for femoral tunnel completion was 14 min 35 s for the procedure without the guide and 4 min 20 s with the guide.

Conclusion
US technology can be used for the creation of a rectangular femoral bone tunnel during an arthroscopic ACL reconstruction procedure. The use of a specific cutting guide can reduce the time for femoral tunnel completion. Additional experience will further reduce the time of the procedure.
The church bridge project focus group results: African American perspectives of weight management programs to improve nutrition and physical activity behaviors
Authors: Lemacks Jennifer L. , Abbott Laurie S. , Greer Tammy , Gunn Renee , Bryant Ashley , Bradford LaShaundrea , Ralston Penny A. 
Published: July 2021

AbstractBackgroundThe prevalence of obesity is disproportionately high among African Americans in the Southern US. More information is needed about factors that influence participation in nutrition and physical activity programs to promote healthy weight.ObjectiveThe purpose of this study is to explore the weight management perceptions of young to middle aged adult African Americans.MethodsThe Church Bridge Project intervention participants were recruited for two focus groups. Qualitative data were recorded, transcribed and a thematic content analysis was conducted to identify major themes.ResultsBarriers included technology learning curve/burden and competing priorities. Facilitators included support, limited cost, convenience, and health. Participants perceived the term “weight management” program as overwhelming and defeating.ConclusionThe Church Bridge Project model confirmed social support and disease prevention as key factors for weight management. Further work should substantiate social support as a key factor to guide minority health efforts.
The membership of parties abroad: a case study of the UK
Authors: Collard Susan , Kernalegenn Tudi 
Published: July 2021

AbstractAgainst a long trend decline in the membership of political parties in Western democracies, there has been an unexpected surge in the UK since 2015. Interestingly, this phenomenon has also been observed amongst British expatriates, despite their historically very low levels of engagement. Our paper explores this development using a multi-methods approach to investigate its impact across the three main parties, comparing the relative importance of supply-side and demand-side factors in each case. We show that the creation and development of British parties abroad are the result of two contrasting dynamics: a top-down one, which gives legitimacy and structure and in some cases, resources, and a bottom-up one, which gives purpose but also networks. Our survey of British expatriate party members reveals a diversity of triggers and motivations for membership, making an original contribution to the wider literature on party membership and on the political engagement of emigrants.
Fermented pork fat (Sa-um) and lifestyle risk factors as potential indicators for type 2 diabetes among the Mizo population, Northeast India
Authors: Lalrohlui Freda , Ghatak Souvik , Zohmingthanga John , Hruaii Vanlal , Kumar Nachimuthu Senthil 
Published: July 2021

AbstractOver the last few decades, Mizoram has shown an increase in cases of type 2 diabetes mellitus; however, no in-depth scientific records are available to understand the occurrence of the disease. In this study, 500 patients and 500 healthy controls were recruited to understand the possible influence of their dietary and lifestyle habits in relation with type 2 diabetes mellitus. A multivariate analysis using Cox regression was carried out to find the influence of dietary and lifestyle factors, and an unpairedttest was performed to find the difference in the levels of biochemical tests. Out of 500 diabetic patients, 261 (52.3%) were males and 239 (47.7%) were females, and among the control group, 238 (47.7%) were males and 262 (52.3%) were females. Fermented pork fat, Sa-um (odds ratio (OR) 18.98), was observed to be a potential risk factor along with tuibur (OR 0.1243) for both males and females. Creatinine level was found to be differentially regulated between the male and female diabetic patients. This is the first report of fermented pork fat and tobacco (in a water form) to be the risk factors for diabetes. The unique traditional foods like Sa-um and local lifestyle habits like tuibur of the Mizo population may trigger the risk for the prevalence of the disease, and this may serve as a model to study other populations with similar traditional practices.
ESRFuzzer: an enhanced fuzzing framework for physical SOHO router devices to discover multi-Type vulnerabilities
Authors: Zhang Yu , Huo Wei , Jian Kunpeng , Shi Ji , Liu Longquan , Zou Yanyan , Zhang Chao , Liu Baoxu 
Published: July 2021

AbstractSOHO (small office/home office) routers provide services for end devices to connect to the Internet, playing an important role in cyberspace. Unfortunately, security vulnerabilities pervasively exist in these routers, especially in the web server modules, greatly endangering end users. To discover these vulnerabilities, fuzzing web server modules of SOHO routers is the most popular solution. However, its effectiveness is limited due to the lack of input specification, lack of routers’ internal running states, and lack of testing environment recovery mechanisms. Moreover, existing works for device fuzzing are more likely to detect memory corruption vulnerabilities.In this paper, we propose a solution ESRFuzzer to address these issues. It is a fully automated fuzzing framework for testing physical SOHO devices. It continuously and effectively generates test cases by leveraging two input semantic models, i.e., KEY-VALUE data model and CONF-READ communication model, and automatically recovers the testing environment with power management. It also coordinates diversified mutation rules with multiple monitoring mechanisms to trigger multi-type vulnerabilities. With the guidance of the two semantic models, ESRFuzzer can work in two ways: general mode fuzzing and D-CONF mode fuzzing. General mode fuzzing can discover both issues which occur in the CONF and READ operation, while D-CONF mode fuzzing focus on the READ-op issues especially missed by general mode fuzzing.We ran ESRFuzzer on 10 popular routers across five vendors. In total, it discovered 136 unique issues, 120 of which have been confirmed as 0-day vulnerabilities we found. As an improvement of SRFuzzer, ESRFuzzer have discovered 35 previous undiscovered READ-op issues that belong to three vulnerability types, and 23 of them have been confirmed as 0-day vulnerabilities by vendors. The experimental results show that ESRFuzzer outperforms state-of-the-art solutions in terms of types and number of vulnerabilities found.
Left atrial ıntramural hematoma after radiofrequency catheter ablation of left lateral accessory pathway
Authors: Yaşar Salim , Gökoğlan Yalçın , Görmel Suat , Asil Serkan , Kabul Hasan Kutsi 
Published: July 2021

AbstractWe report a case of left atrial hematoma after ablation of left lateral concealed accessory pathway. A 46-year-old male patient experienced chest pain after radiofrequency ablation. Transthoracic echocardiography and computed tomography revealed the intramural mass consistent with hematoma in the left atrium. He was hemodynamically stable, and conservative approach was decided. Atrioventricular groove is a vulnerable part of left atrium, and ablation of left free wall accessory pathway may require targeting both atrial and ventricular surfaces of the mitral annulus. Avoidance of forceful catheter manipulation during the electrophysiological procedure is important for prevention of this complication. Optimal periprocedural anticoagulation might reduce the risk of procedure-related thromboembolic complications, but electrophysiologists should always pay attention to an intramural hematoma that may occur after radiofrequency catheter ablation.
Taxonomy and phylogeny of Resinicium sensu lato from Asia-Pacific revealing a new genus and five new species (Hymenochaetales, Basidiomycota)
Authors: Yu Jia , Wang Xue-Wei , Liu Shi-Liang , Shen Shan , Zhou Li-Wei 
Published: July 2021

ABSTRACTResinicium, belonging to Hymenochaetales, Agaricomycetes, is a worldwide genus of corticioid wood-inhabiting fungi. To improve the knowledge of species diversity within the Hymenochaetales, two dozen specimens from Asia-Pacific preliminarily identified to be members of Resinicium sensu lato were carefully studied from morphological and phylogenetic perspectives. From these specimens, a new monotypic genus Skvortzoviella, and five new species, viz. Resinicium austroasianum, R. lateastrocystidium, Skvortzovia dabieshanensis, S. qilianensis and Skvortzoviella lenis are described; moreover, a new basal lineage of Resinicium represented by a Vietnam specimen and three Chinese specimens of S. pinicola are identified. The six newly proposed taxa are morphologically compared with related genera and species, while the family positions of Resinicium, Skvortzovia, and Skvortzoviella within the Hymenochaetales are still ambiguous. In addition, the ancestral geographic origin of Resinicium, even though inconclusive, is now thought to be Asia-Pacific instead of tropical America as previously assumed.
Phytochemical evaluation and pharmacognostic standardization of Syzygium palghatense endemic to Western Ghats
Authors: Snehalatha V. R. , Rasmi A. R. 
Published: July 2021

Abstract
Background
The plants belonging to the genus Syzygium has received much attention since ancient times due to its multidimensional uses for mankind. These plants in general, reported to contain a wide array of phytomolecules with a broad spectrum of biological activities that include antihypoglycemic, antioxidant, anti-inflammatory, anticarcinogenic, and antihypertensive properties. The pharmacological potential of S. palghatense which is endemic to Western Ghats has not yet been investigated. The present study was intended to examine the potential benefits of the leaves and bark of S. palghatense.

Results
Morpho-anatomical studies of S. palghatense provided useful details for the identification. The pharmacological characterization of the plants shows significant results in their studied parameters. The total phenolic and flavonoid contents were higher in methanolic extracts of leaves and bark of S. palghatense. Methanolic extract of the leaves and bark have superior antioxidant capacity when compared with the chloroform, ethyl acetate, and distilled water extracts. A significant result in alpha amylase and alpha glucosidase enzyme activity was exhibited when antidiabetic study was performed.

Conclusion
The current study showed that the methanolic extract of S. palghatense leaves and bark have significant pharmacognostic properties and potential antioxidant and antidiabetic compounds. Phytochemical studies portray the presence of several biologically active secondary metabolites, including essential oil, alkaloid, glycosides, carbohydrate, tannins, reducing sugar, phenolics, and saponins, which may be the reason for its biological properties. As compared to bark, leaves of S. palghatense possess significant activity toward all the biological properties tested.