bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed Analysis and Radiomic Prediction of First Progression Sites of First-Line Targeted Therapy for EGFR-Mutant Lung Adenocarcinoma Patients With Systemic Metastasis
Authors: Li Xiaoyang , Hou Runping , Yu Wen , Zhu Xueru , Li Hongwei , Yang Yidong , Qian Dong , Fu Xiaolong 
Published: October 2021

BackgroundWe aimed to analyze the first progression sites of first-line tyrosine kinase inhibitor (TKI) treatment for EGFR-mutant lung adenocarcinoma patients with systemic metastasis to recognize the potential candidates who might benefit from radiotherapy and establish a radiomic-based model to predict the first progression sites.Materials and MethodsWe retrospectively collected the clinical information and pre-treatment chest CT images of patients in Shanghai Chest Hospital from 2013 to 2017. All patients were diagnosed with stage IV EGFR-mutant lung adenocarcinoma and received TKI as first-line treatment. The first progression sites and survival were analyzed. The pre-treatment chest non-contrast CT images were utilized to establish a radiomic-based model to predict the first progression sites.ResultsWe totally collected 233 patients with systemic metastasis, among whom, there were 84 (36.1%) and 149 (63.9%) patients developing first progression in original lesions (OP) and new lesions (NP), respectively. The PFS and OS of patients with OP were longer than those with NP (PFS 11 months vs. 8 months, p = 0.03, OS 50 months vs. 35 months, p = 0.046). For 67.9% of the patients with OF, disease progressed within five sites (oligoprogression). The radiomic-based model could predict the progression sites with an AUC value of 0.736, a specificity of 0.60, and a sensitivity of 0.750 in the independent validation set.ConclusionAmong patients with systemic metastasis, there were 36.1% of patients developing OP at first progression who had a better prognosis than those developing NP. Patients with OP may be potential candidates who might benefit from radiotherapy. Radiomics is a useful method to distinguish patients developing OP and could provide some indications for radiotherapy.
Time Perception in Prodromal Alzheimer's Dementia and in Prodromal Dementia With Lewy Bodies
Authors: Pai Ming-Chyi , Yang Chiu-Jun , Fan Sheng-Yu 
Published: October 2021

Background: Time perception is a subjective experience or sense of time. Previous studies have shown that Alzheimer's dementia (AD) patients have time perception deficits compared to a cognitively unimpaired control group (CU). There are only a few studies on dementia with Lewy bodies (DLB) patients' time perception in comparison with CU and AD patients. Early intervention and prescription of the right medicine may delay the deterioration of AD and DLB, moreover, knowing how prodromal AD (prAD) and prodromal DLB's (prDLB) time perception differ from each other might be helpful for future understanding of these two dementias. Therefore, the purpose of this study is to explore the difference in time perception performance between prodromal AD and prodromal DLB.Methods: We invited people diagnosed with prAD, prDLB, and CU to participate in this study. Tests of verbal estimation of time and time interval production were used to assess their time perception. We analyzed the average time estimation (ATE), absolute error score (ABS), coefficient of variance (CV), and subjective temporal unit (STU) within the three groups.Results: A total of 40 prAD, 30 prDLB, and 47 CU completed the study. In the verbal estimation test, the CV for the prAD was higher than both prDLB and CU at the 9 s interval, and the CV of prAD was higher than CU at the 27 s interval. In the time interval production test, the subjective time units of prDLB were higher than prAD at the 10 s interval, while those of both prDLB and CU were higher than prAD at the 30 s interval. The percentage of subjects with STU &lt; 1.0 s, indicating overestimation, was higher in prAD than both prDLB and CU.Conclusion: Time perception of prAD patients showed imprecision and overestimation of time, while prDLB tended to underestimate time intervals. No significant difference was found in accuracy among the three groups. It is speculated that the clinical and pathological severity of the two prodromal dementia stages may be different, and some patients have not yet had their time perception affected.
Human Papillomavirus Vaccine Course Completion Among Gay and Bisexual Men Who Have Sex With Men From a Time-Limited HPV Vaccination Catch-Up Program in Victoria, Australia
Authors: Htaik Kay , Fairley Christopher K. , Chen Marcus Y. , Wigan Rebecca , Rodriguez Elena , Bradshaw Catriona S. , Chow Eric P. F. 
Published: October 2021

Background: To examine completion of the human papillomavirus (HPV) vaccination 3-dose regimen and factors associated with completion among men who have sex with men (MSM) aged ≤ 26 years participating in a time-limited HPV catch-up vaccination program in Victoria, Australia.Methods: MSM who received their first dose of HPV vaccine at Melbourne Sexual Health Centre in 2017 were followed until October 2019. Vaccination completion was defined as those who received three doses. Multivariable logistic regression was performed to examine factors associated with vaccine completion.Results: 931 of 1,947 (47.8%) eligible men received at least one dose of HPV vaccine, 750 (38.5%) received two and 590 (30.3%) received three doses. The median time to receiving the second and third dose was 2.8 (IQR = 2.1–4.8) and 7.2 (IQR = 6.3–10.7) months, respectively. Gay men had higher odds of receiving three doses compared to bisexual men (aOR = 2.17; 95%CI: 1.16–4.04). Compared with HIV-negative MSM not taking PrEP, HIV-positive MSM were more like to complete vaccination (aOR = 3.92, 95%CI: 1.62–9.47) but no difference was found compared to HIV-negative men taking PrEP (aOR = 1.55; 95%CI: 0.95–2.53).Conclusion: Less than one-third of men aged ≤ 26 years completed the three doses of HPV vaccine. Further studies are needed to understand the barriers of men not completing the vaccine.
Test-Retest Reliability of Ultrasound Imaging of Lumbar Multifidus Muscle
Authors: Sokunbi Oluleke Ganiyu 
Published: October 2021

Background to the study: Muscle strength and muscle size measurement are useful indicator of musculoskeletal pathology but it seems difficult at the moment to isolate individual paravertebral muscle for strength testing. It may therefore be useful to measure muscle size which can be achieved in vivo using diagnostic imaging technique.
Purpose of the study: The purpose of this study is to demonstrate test-retest reliability of using diagnostic ultrasound imaging in the assessment of multifidus cross sectional area (CSA).
Materials and method: Five apparently healthy volunteers (2 males 3 females) whose ages ranged from 23 to 35 years participated in this study. FF Sonic UF-750XT diagnostic ultrasound imaging machine with a 5MHz curvilinear transducer was used for ultrasound imaging oflumbar multifidus muscle.
Results: The results shows that the average scores of lumbar multifidus ranged from 5.3cm2 to 8.6cm2. The test retest reliability for measuring lumbar multifidus on both single (0.996) and average measures (0.999) was good (P< 0.05).
Conclusion: Ultrasound imaging could be said to be a reliable method that could be used by physiotherapist in evaluating multifidus muscle size which in turn could be a useful guide to the assessment of the effects of low back pain (LBP) and in the evaluation of the efficacy of common therapeutic intervention for LBP disorders.
KEY WORDS: Multifidus, Reliability, Ultrasound Imaging
Job Evaluation of Clinical Physiotherapists in the South West of Nigeria
Authors: Onigbinde Ayodele Teslim , Adedoyin Rufus A , Sangodeyi Bukola Janet 
Published: October 2021

Background ofthe study: Resourcefulness is the quality of being able to cope with a difficult situation and have imaginative abilities while service development processes allow the building and testing of services and related component. The involvement of physiotherapists in supervision, administration, teaching and research in health sciences is yet to be ascertained.
Aims: The primary purpose of this study was to evaluate level of involvement of clinical physiotherapists in administration, teaching, research and policy formulation, human resources and information technology.
Method: One hundred (100) copies of self-administered questionnaire adopted from National Health services job evaluation questionnaire were administered to physiotherapists in selected Federal and State Hospitals. The response rate was 71 %. The data was analysed using descriptive Statistic.
Results: The result showed that 97.2%,84.5%,76.6% and 58.5% of clinicians were resourceful in effective patient communication, analytical skill, patient care and freedom of action respectively. Also 10% carried out research regularly and 35.2% carried it out occasionally. About 47.9% and 80.3% were resourceful in human resources management and policy formulation respectively for physiotherapists in the chief cadre. The assistant Chief Physiotherapists were found to be more resourceful than the Chief Physiotherapists in the area of resource management. The study further showed that only 17.4% of the physiotherapists were involved in utilizing information technology.
Conclusion: This study concluded that clinicians are not highly resourceful especially in the areas of human resources, policy and research, and information technology but were involved in effective communication, judgment and analytical skills, patient care and have freedom of actions.
KEY WORDS: Resourcefulness, Administration, Physiotherapy, Policy
Gender Differences in Cardiovascular Response to Upper Extremities Isometric Exercises in Normotensive Subjects
Authors: Mbada Chidozie E , Akinwande O A , Babalola J F , Seyi-Adeyemo O R , Odejide A S 
Published: October 2021

Background and objective: Studies on gender differences in cardiovascular responses to isometric exercise have been numerous and conflicting. The objective of this study was to determine if the cardiovascular responses to upper extremities isometric exercises differ between apparently healthy male end female subjects.
Methods: One hundred and sixty apparently healthy adults with the mean age of 39.0 ± 11.04 years were consecutively recruited into the study. This consisted of 80 males (39.0 ± 10.82 years) and 80 females (38.96 ± 11.25). Data were obtained on participants' age, height, weight, body mass index, blood pressure, heart rate, and Rate Pressure Product. Data were summarized using descriptive statistics of mean and standard deviation. Independent t-test was used to compare physical characteristics between genders while repeated measure of ANOVA was used to compare the pre and post isometric exercises cardiovascular parameters between genders. Level of significance for all tests was set at p< 0.05.
Results: The baseline cardiovascular parameters were not significantly different (p> 0.05) between the male and the female participants. The post exercise cardiovascular parameters were significantly greater (p< 0.05) than the baseline values without gender bias. However, the post exercise SBP and RPP were significantly different (p< 0.05) between the male and the female participants respectively.
Conclusion: Isometric exercises of the upper limbs can lead to a significant increase in cardiovascular parameters among apparently healthy male and female subjects. Higher ventricular contraction is evoked among males leading increased SBP while the myocardial oxygen uptake and the measure of the oxygen consumption of the heart muscles of the female participants in response to upper extremities isometric exercises is higher than that of the males as demonstrated by the RPP.
Key words: Isometric exercises, cardiovascular response, upper extremities exercises.
An Assessment of Erognomic Work Stations and Pain among Computer Users in a Nigerian University Community
Authors: Johnson O E , Onigbinde Ayodele T , Onasanya S A , Emechete A E I , Gbela T O 
Published: October 2021

Background and Objective: Computer usage is a trend in technology advancement that is common with virtually all jobs and it predisposes all users to avoidable musculoskeletal injuries. This study aimed at determining Computer Workstation (CW) ergonomics among computer users in ObafemiAwolowo University Ile-Ife, Nigeria. Also the distributions of musculoskeletal pain experienced by computers users were determined.
Methods: One hundred and fifty (150) participants were recruited using cluster sampling technique. Participants must have been users for 6 months, working l5hours per week .The participant's bio-data were recorded and CW were identified and measured for footrest, casters, keyboard height, seat height, monitor height, seat back angle and arm angle. They were asked if they were experiencing pain, its location and cause. Data were analysed using descriptive statistics.
Results: Results obtained showed that 23 (15.3%) ofthe CW had 5 casters, and just 3 (2%) had footrests while there were, 130 (86.7%) and 104 (69.3%) with ideal chair and keyboard heights respectively. Also, there were 130 (86.7%) and 136 (90%) with ideal monitor height and seat back angle respectively. Results showed that 105 (70%) of the participants experienced pain and mostly (52.4 % of the 70%) in the back with mean pain intensity 7 on a 10 point pain scale. Participants; (38) 25.3%, believed that CW arrangement was the cause of the pain.
Conclusion: This study concluded that majority of the CW did not meet the standard description of CW and majority ofthe computer had pain in the low back as at the time of study.
Keywords: Ergonomic workstation, Computer users, Musculoskeletal Pain, Nigerian University
Effect of Ind AS on Earnings Management in Selected FMCG Companies in India
Authors: Nandini G , Tamilselvi T.A 
Published: October 2021

The Corporate frauds have increased drastically which is witnessed in the last decade in India and around the world. Managers use their judgement in analysing the financials and modification of statements which is the origination for earnings management. This paper discusses about earnings management evaluation after adoption of Ind AS for the first time by leading fast moving consumer goods companies in India. Random sampling is used to select three companies and analyse for a period of 6 years (2014-2020)
The Jones Model (1991) is used for evaluation of earnings management and tested using the regression model to arrive at the findings. The Jones model of non-discretionary accruals is used for the purpose of evaluation of accounting manipulation. The Jones model has non-discretionary and discretionary accruals estimated in the model. The R square is 14.3% and F-test significance value is greater than 0.05 therefore null hypothesis is accepted concluding there is no change in earnings management after the new standards.
A Case Study on Information and Communication Technology in Empowering the Visually Challenged Women in Inclusive Eduction
Authors: Naneetha R , Srihari M 
Published: October 2021

Brigham Young posits that ‘If you educate a man, you educate an individual, but you educate a woman, you educate a nation. Even now, educating a woman is challenging in cultural practices dominated by values and beliefs in the social system. Women in developing countries face significant barriers in accessing education, whereas gender inequality in communities, society, and the workplace hinders economic and social development. Education as a means of empowerment of women can bring changes socially, economically, and politically. An American author, Helen Keller, says that ‘Education cannot be created with ease, only through the experience of trial and sufferings it can be strengthened, inspired and achieved. Women with visual impairment are still receiving less schooling, denied social acceptance, and lack of access to information also became an impediment added to their woes. Perhaps, ICT has changed visually impaired women’s lives by giving them access to mainstream and trying to be independent financially and socially.
Furthermore, ICT has allowed visually impaired women in accessing braille materials, operating assistive devices and applications that build confidence, recognition, self-expression, and acquire knowledge. This study explores how inclusive education creates an opportunity for visually impaired women in overcoming societal stigma by achieving personal, social, emotional, and academic goals. ICT in education plays an essential role in developing women and facilitates empowerment, calibrated to a new order of society’s structure and functions.
Revival and Resurgence of Our Lost GEM - The Ancient Indian Education System
Authors: Jain Sonali Bhandari , Choudhary Surabhi , Philip Joanna 
Published: October 2021

After witnessing the unruly and disruptive behaviour amongst college students on trivial topics, a study was conducted to find the reason behind it. The study consisted of students discussing topics like politics, situational problems etc. and it was observed that students lacked the concept of perception. Studying this even further, it was found that the cause for this was because our modern-day education focused more on literally manufacturing people for jobs and less on value systems and critical thinking. The present education system is finding it very difficult in ensuring the required quality that every student must possess. This also gives rise to students being confused about their career paths and life in general. They don’t realise their true potential and abilities and thus start developing a “follow the crowd” mentality.
To improve this situation, a radical change has to be brought into the education system and this change can only be supported by retrospection of India’s ancient education system. The focus must now divert towards developing skills rather than just concentrating on academics. These ancient practices cannot be applied as it is in this modern era. Hence, their application calls for reinvention and resurgence to benefit today’s students.
Instruction of Mathematics in Higher Education in the Covid-19 Pandemic: The Case of Turkey
Authors: Ardıç Mehmet Alper 
Published: October 2021

The purpose of this study is to determine how mathematics instruction is carried out at the higher level of education in Covid-19 pandemic and what are the effects of these teaching activities. In the study, the case study model was used in which 30 lecturers with expertise in mathematics from 20 different universities in Turkey participated. In the study, the opinion form was used as a data collection tool. Descriptive analysis and content analysis methods were used in analyzing the data. It was found that before the pandemic, the use of technology in mathematics education by the lecturers was quite rare and at a basic level. In the pandemic process, it was observed that lecturers conducted their teaching synchronously or asynchronously with the traditional teaching approach, as before the pandemic, with distance education as the teacher-centered approach. It was understood that the main problems encountered during distance education were the difficulties encountered in teacher-student interaction and the inability to carry out assessment and evaluation activities in a healthy manner. It has been observed that the problems encountered especially in assessment and evaluation make it difficult to understand the actual impact of teaching mathematics during the pandemic on student learning. In fact, it was found that at the beginning of the pandemic, universities gave various instructions to their lecturers various trainings on distance education. However, these instructions were usually technical in scope and insufficient to overcome the difficulties encountered in the process, so that mathematics instruction was carried out with an understanding of ‘emergency distance education” rather than formal distance education. On the other hand, the experience of distance education gained during the pandemic process had a positive influence on the views of a significant proportion of the lecturers on the integration of technology in mathematics education.
An Analyzing of the Relationship Between Exercise Addiction and Obesity Awareness
Authors: Zengin Samet , Kırkbir Fatih 
Published: October 2021

Depending on the developing technology, individuals started to pursue a less active lifestyle. The sedentary lifestyle has brought along many health problems. One of these health problems is obesity. Awareness of obesity is important for individual health. One of the applications that can be implemented to cope with obesity is exercise. This study aims to analyze the relationship between university students’ exercise addiction and obesity awareness. Therefore, 249 university students (132 males, 117 females) participated in the study. In the study, the “Exercise Addiction Scale” developed by Tekkurşun-Demir, Hazar and Cicioğlu (2018) and the “Obesity Awareness” scale developed by Allen (2011) and adapted to Turkish culture by Kafkas and Özen (2014) were used as data collection tools. Data were analyzed with descriptive statistical methods, t-test for independent groups and one-way variance (ANOVA). Correlation test was employed to determine the relationship between exercise addiction and obesity awareness. As a result of the research, it was determined that students’ awareness of exercise addiction and obesity was at a moderate level. It was determined that exercise addiction had a significant effect on average the number of steps taken per day. Besides, it was determined that there was a low level of a positive relationship between exercise addiction and obesity awareness.
An Analysis of Relevant Studies on Language Learning Strategies in Teaching Turkish as a Foreign Language
Authors: Polatcan Faruk , ER Onur , Coban Ismail 
Published: October 2021

It is clear that language learning strategies play very important roles in the understanding of language learning processes, as well as in the skills students develop in learning a foreign or second language. In this study, studies on language learning strategies in teaching Turkish to foreigners were examined. In this context, content analyses of 24 studies published by 2021 were carried out. While scanning design was used in most of the reviewed studies, the Oxford Language Learning Strategies Scale (1990) was used as a measurement tool. As a result of the studies, it was found that women from foreign students who learn Turkish as a foreign language use language learning strategies more effectively than men, and the use of language learning strategies remains as age increases. As a result of the research, the lecturers were advised to guide students’ language learning strategies and to use their language learning strategies in lessons. Regarding the use of language learning strategies, it has been recommended to researchers at different language levels and to conduct research with larger populations.