bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urine Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 to Detect Pediatric Cisplatin-Associated Acute Kidney Injury
Authors: McMahon Kelly R. , Chui Hayton , Rassekh Shahrad Rod , Schultz Kirk R. , Blydt-Hansen Tom D. , Mammen Cherry , Pinsk Maury , Cuvelier Geoffrey D. E. , Carleton Bruce C. , Tsuyuki Ross T. , Ross Colin J.D. , Devarajan Prasad , Huynh Louis , Yordanova Mariya , Crépeau-Hubert Frédérik , Wang Stella , Cockovski Vedran , Palijan Ana , Zappitelli Michael 
Published: November 2021

Background
Few studies have described associations between the AKI biomarkers urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) with AKI in cisplatin-treated children. We aimed to describe excretion patterns of urine NGAL and KIM-1 and associations with AKI in children receiving cisplatin.

Methods
Participants (n=159) were enrolled between 2013 and 2017 in a prospective cohort study conducted in 12 Canadian pediatric hospitals. Participants were evaluated at early cisplatin infusions (at first or second cisplatin cycle) and late cisplatin infusions (last or second-to-last cycle). Urine NGAL and KIM-1 were measured (1) pre-cisplatin infusion, (2) post-infusion (morning after), and (3) at hospital discharge at early and late cisplatin infusions. Primary outcome: AKI defined by serum creatinine rise within 10 days post-cisplatin, on the basis of Kidney Disease Improving Global Outcomes guidelines criteria (stage 1 or higher).

Results
Of 159 children, 156 (median [interquartile range (IQR)] age: 5.8 [2.4–12.0] years; 78 [50%] female) had biomarker data available at early cisplatin infusions and 127 had data at late infusions. Forty six of the 156 (29%) and 22 of the 127 (17%) children developed AKI within 10 days of cisplatin administration after early and late infusions, respectively. Urine NGAL and KIM-1 concentrations were significantly higher in patients with versus without AKI (near hospital discharge of late cisplatin infusion, median [IQR] NGAL levels were 76.1 [10.0–232.7] versus 14.9 [5.4–29.7] ng/mg creatinine; KIM-1 levels were 4415 [2083–9077] versus 1049 [358–3326] pg/mg creatinine; P<0.01). These markers modestly discriminated for AKI (area under receiver operating characteristic curve [AUC-ROC] range: NGAL, 0.56–0.72; KIM-1, 0.48–0.75). Biomarker concentrations were higher and better discriminated for AKI at late cisplatin infusions (AUC-ROC range, 0.54–0.75) versus early infusions (AUC-ROC range, 0.48–0.65).

Conclusions
Urine NGAL and KIM-1 were modest at discriminating for cisplatin-associated AKI. Further research is needed to determine clinical utility and applicability of these markers and associations with late kidney outcomes.
La noción de frontera como espacio social de interacción y como unidad de análisis para la Historia Regional
Authors: MAN Ronen 
Published: November 2021

Desde una perspectiva teórica centrada en los estudios regionales el trabajo aborda los conceptos de “frontera” y de “ámbito regional” como espacios sociales de interacción que trascienden los marcos estrictamente geográficos. Se basa en el caso específico de la región de la norpatagonia argentina, como ejemplo históricamente determinado de relaciones interregionales de sujetos y bienes en el espacio sur andino. El texto propone discutir la preeminencia de una serie de supuestos arraigados, tales como la orientación atlántica, ganadera, blanca y europea predominante en estos espacios. Se destaca además, que fueron diversos los factores que favorecieron la supervivencia de circuitos económicos, sociales y culturales de carácter “centrífugos”, en detrimento de las intenciones nacionalizadoras de los nacientes Estados por imponer tendencias particularistas. Palabras clave: historia regional- frontera- ámbito regional- norpatagonia- Argentina.
La confesión y el control sobre los cuerpos en la retórica del manual de Doctrina Cristiana y Catecismo de Valdivia. Capitanía General de Chile, CA. 1650
Authors: Villar-Laz Carolina 
Published: November 2021

El presente trabajo tiene por objetivo el estudio del control ejercido sobre los cuerpos y sobre las relaciones que se desarrollaron entre los géneros, en el marco de la acción evangelizadora llevada a cabo por la Compañía de Jesús en el sur del Chile colonial, a comienzos del siglo XVII. Durante el período, se empezaron a concretar los alcances del Concilio de Trento situación en la que el clero secular y el regular se embarcan en la transformación de la evangelización en función de las sugerencias teológicas surgidas de la ecumene cristiana. En los territorios coloniales americanos, estas políticas eclesiásticas se concretaron en diversas líneas pastorales, entre la que nos interesa analizar la surgida en el contexto de la Guerra Defensiva, en la frontera de la Capitanía chilena. El control sobre los cuerpos se plantea desde el particular dispositivo de poder que en nuestro trabajo definimos como la confesión, tema que venimos reconstruyendo en una investigación más amplia. Palabras clave: Doctrina tridentina; Misiones jesuitas; Chile Colonial; Biopoder
Represión y conservadurismo cultural en Córdoba: el posicionamiento político-ideológico de la intervención federal de Nores Martínez sobre el partido Comunista (Junio 1962-Octubre 1963)
Authors: Bonvillani Paola 
Published: November 2021

Durante la administración de José María Guido, el poder central mantuvo intervenidas diversas provincias. En Córdoba, la experiencia de gobierno del interventor federal Rogelio Nores Martínez, estuvo fuertemente influida por el poder de la élite tradicional, basado en la presencia de la Iglesia Católica y de un ejército caracterizado por un arraigado antiperonismo. Asimismo, la lucha contra el comunismo se constituyó en tema central del universo ideológico compartido por la elite tradicional y los sectores militares y eclesiásticos cordobeses.En virtud de lo anterior, este artículo tiene por objeto analizar algunos aspectos relativos al período de gobierno de la intervención federal de Rogelio Nores Martínez en la provincia de Córdoba, abordando especialmente los principales puntos de conflicto que esta gestión mantuvo con el Partido Comunista y la actuación de este durante la década del ´60.Palabras clave: partido comunista; represión; conservadurismo cultural; intervención federal
Aplikasi Layanan Administrasi Kependudukan Berbasis Web Pada Kelurahan Mangun Jaya
Authors: Budi Budi , Subekti Zaenal Mutaqin , . Rahmadi , Suryadi Muhamad Dedi , Ardiansyah Ricky 
Published: November 2021

Pelayanan data kependudukan kepada warga pada kelurahan mangun jaya kecamatan tambun selatan mengalami kendala, dalam melakukan pelayanan data kependudukan membutuhkan waktu yang lama seperti surat permohonan pindah, surat permohonan kartu keluarga, surat permohonan kartu tanda penduduk, surat keterangan tidak mampu, surat keterangan domisili tempat tinggal, surat keterangan kelahiran, surat keterangan kematian dan surat pengantar catatan kepolisian. Untuk mengatasi permasalahan pelayanan data penulis membuat aplikasi layanan kependudukan berbasis web pada kelurahan mangun jaya dengan merubah prosedur dari manual ke komputerisasi. Metode pengembangan sistem yang digunakan adalah waterfall dimulai dari requirement membuat analisa kebutuhan dari prosedur dalam pelayanan data pada kelurahan mangun jaya, kedua desain membuat perancangan sistem pelayanan data menggunakan pemodelan use case, activity diagram dan sequence diagram, tahap ketiga implementasi yaitu melakukan penerapan dari desain ke source code sesuai dengan alur, tahap terakhir testing melakukan pengujian aplikasi layanan administrasi kependudukan menggunakan pendekatan blackbox dan uji beta oleh pengguna dengan tingkat kepuasan sebesar 89%
Pengaruh Kualitas Produk Terhadap Keputusan Pembelian Pada Kedai Kopi Belrum Kecamatan Panumbangan Kabupaten Ciamis
Authors: Hendi Sobari  , Gungun Gunawan  
Published: November 2021

Semakin menjamurnya bisnis kopi merupakan salah satu peluang untuk mendapatkan penghasilan, di lain sisi dengan menjamurnya bisnis kopi akan menimbulkan masalah lain yaitu penurunan pembelian yang diakibatkan karena terlalu banyaknya kedai kopi. Tujuan penelitian ini adalah untuk : 1) Mengetahui kualitas produk pada Kedai Kopi Belrum Ciamis. 2) Mengetahui keputusan pembelian pada Kedai Kopi Belrum Ciamis. 3) Mengetahui seberapa besar pengaruh kualitas produk terhadap keputusan pembelian pada Kedai Kopi Belrum Ciamis. Metode penelitian yang digunakan adalah metode deskriptif kuantitatif. Alat analisis yang digunakan adalah regresi sederhana. Hasil penelitian menunjukkan bahwa : 1) Kualitas produk Kedai Kopi Belrum Ciamis adalah sangat tinggi. 2) Keputusan pembelian pada Kedai Kopi Belrum Ciamis adalah sangat tinggi. 3) Pengaruh kualitas produk terhadap keputusan pembelian pada Kedai Kopi Belrum Ciamis adalah kuat dengan menghasilkan angka 0,783 dan koefisien penentunya sebesar 61,3% sedangkan sisanya 38,7% dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini.
Pengaruh Cause Related Marketing Terhadap Trust In Cause Related Marketing Dan Brand Loyalty
Authors: Cen Lu Lay  , Ika Gunawan  , Felicia Abednego  , Shirleen Natasha  
Published: November 2021

Isu-isu mengenai pembangunan yang berkelanjutan dan kegiatan tanggung jawab sosial atau Corporate Social Responsibility terutama Cause Related Marketing telah banyak dibahas. Namun di Indonesia belum banyak penelitian yang membahas topik ini. Hal ini menjadi menarik karena perusahaan-perusahaan memiliki dorongan yang kuat untuk meningkatkan kegiatan Cause Related Marketing sebagai nilai tambah buat perusahaan. Penelitian ini akan menganalisis peranan Cause Related Marketing kaitannya dengan Trust in Cause Related Marketing dan Brand Loyalty. Pendekatan metode penelitian ini mengunakan metode kuantitatif. Penelitian ini mengumpulkan data dengan menyebar kuesioner kepada responden. Metode penarikan sampel dalam penelitian ini menggunakan teknik purposive sampling dengan kriteria mahasiswa/i di kota Bandung yang mengetahui Cause Related Marketing. Jumlah sampel yang terkumpul adalah 210 orang. Teknik pengolahan data menggunakan analisis regresi. Hasil penelitian menunjukkan bahwa Cause Related Marketing mempengaruhi Brand Loyalty, Cause Related Marketing mempengaruhi Trust in Cause Related Marketing, dan Trust in Cause Related Marketing tidak mempengaruhi Brand Loyalty.

Kata Kunci: Cause Related Marketing, Trust in Cause Related Marketing, Brand Loyalty
Revisiting the Open Sampling format: Improving risky choices through a novel graphical representation
Authors: Tiede Kevin E. , Henninger Felix , Kieslich Pascal J. 
Published: November 2021

AbstractWhen making risky choices, people often fall short of the norm of expected value (EV) maximization. Previous research has shown that presenting options in the Open Sampling (OSa) format, a 10-by-10 matrix of randomly arranged outcomes, can improve choices and reduce decision times. First, the current research aims to replicate and extend the findings on the OSa format. To this end, we compare OSa to the common description-based format as well as further graphical representations, and investigate the resulting accordance with EV maximization and decision time. Second, we study whether people lower (vs. higher) in numeracy, the ability to use probabilistic and mathematical concepts, particularly benefit from a graphical representation of options. We conducted five high-powered studies (total N = 1,575) in which participants chose repeatedly between two risky gambles, using different populations and gamble-problem sets. Overall, we could not find a benefit of the OSa format in terms of EV accordance in any of the five studies. However, three studies also tested a novel variant of the OSa format with grouped outcomes and found that it consistently improved EV accordance compared with all other formats. All graphical formats led to faster decisions without harming decision quality. The effects of presentation format were not moderated by numeracy in three of the four studies that assessed numeracy. In conclusion, our research introduces a new presentation format which consistently improves risky choices and can also be used to communicate risks in applied contexts such as medical decision making.
Estimating the Effective Lifetime of the z ∼ 6 Quasar Population from the Composite Proximity Zone Profile
Authors: Morey Karna A. , Eilers Anna-Christina , Davies Frederick B. , Hennawi Joseph F. , Simcoe Robert A. 
Published: November 2021

Abstract
The lifetime of quasars can be estimated by means of their proximity zone sizes, which are regions of enhanced flux blueward of the Lyα emission line observed in the rest-frame UV spectra of high-redshift quasars because the intergalactic gas has a finite response time to the quasars’ radiation. We estimate the effective lifetime of the high-redshift quasar population from the composite transmitted flux profile within the proximity zone region of a sample of 15 quasars at 5.8 ≤ z ≤ 6.6 with precise systemic redshifts, and similar luminosities, i.e., −27.6 ≤ M
1450 ≤ −26.4, and thus a similar instantaneous ionizing power. We develop a Bayesian method to infer the effective lifetime from the composite spectrum, including robust estimates of various sources of uncertainty on the spectrum. We estimate an effective lifetime of the quasar population as a whole of

log

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5.7

−
0.3
(
−
0.5
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given by the median and 68th (95th) percentile of the posterior probability distribution. While our result is consistent with previous quasar lifetime studies, it poses significant challenges on the current model for the growth of supermassive black holes located in the center of the quasars’ host galaxies, which requires that quasar lifetimes are more than an order of magnitude longer.
Detection of H2 in the TWA 7 System: A Probable Circumstellar Origin
Authors: Flagg Laura , Johns-Krull Christopher M. , France Kevin , Herczeg Gregory , Najita Joan , Carpenter John M. , Kenyon Scott J. 
Published: November 2021

Abstract
Using HST–COS far-UV spectra, we have discovered warm molecular hydrogen in the TWA 7 system. TWA 7, a ∼9 Myr old M2.5 star, has a cold debris disk and has previously shown no signs of accretion. Molecular hydrogen is expected to be extremely rare in a debris disk. While molecular hydrogen can be produced in starspots or the lower chromospheres of cool stars such as TWA 7, fluxes from progressions that get pumped by the wings of Lyα indicate that this molecular hydrogen could be circumstellar and thus that TWA 7 is accreting at very low levels and may retain a reservoir of gas in the near circumstellar environment.
Molecular Line Observations in Two Dusty Star-forming Galaxies at z = 6.9
Authors: Jarugula Sreevani , Vieira Joaquin D. , Weiss Axel , Spilker Justin S. , Aravena Manuel , Archipley Melanie , Béthermin Matthieu , C. Chapman Scott , Dong Chenxing , Greve Thomas R. , Harrington Kevin , Hayward Christopher C. , Hezaveh Yashar , Hill Ryley , Litke Katrina C. , Malkan Matthew A. , Marrone Daniel P. , Narayanan Desika , Phadke Kedar A. , Reuter Cassie , Rotermund Kaja M. 
Published: November 2021

Abstract
SPT0311-58 is the most massive infrared luminous system discovered so far during the Epoch of Reionization (EoR). In this paper, we present a detailed analysis of the molecular interstellar medium at z = 6.9, through high resolution observations of the CO(6–5), CO(7–6), CO(10–9), [C i](2–1), and p‐H2O(21,1 −20,2) lines and dust continuum emissions with the Atacama Large Millimeter/submillimeter Array. The system consists of a pair of intensely star-forming, gravitationally lensed galaxies (labeled West and East). The intrinsic far-infrared luminosity is (16 ± 4) × 1012
L
⊙ in West and (27 ± 4) × 1011
L
⊙ in East. We model the dust, CO, and [C i] using non-local thermodynamic equilibrium radiative transfer models and estimate the intrinsic gas mass to be (5.4 ± 3.4) × 1011
M
⊙ in West and (3.1 ± 2.7) × 1010
M
⊙ in East. We find that the CO spectral line energy distribution in West and East are typical of high-redshift submillimeter galaxies (SMGs). The CO-to-H2 conversion factor (α
CO) and the gas depletion timescales estimated from the model are consistent with the high-redshift SMGs in the literature within the uncertainties. We find no evidence of evolution of depletion time with redshift in SMGs at z > 3. This is the most detailed study of molecular gas content of a galaxy in the EoR to date, with the most distant detection of H2O in a galaxy without any evidence for active galactic nuclei in the literature.
Molecules with ALMA at Planet-forming Scales (MAPS). II. CLEAN Strategies for Synthesizing Images of Molecular Line Emission in Protoplanetary Disks
Authors: Czekala Ian , Loomis Ryan A. , Teague Richard , Booth Alice S. , Huang Jane , Cataldi Gianni , Ilee John D. , Law Charles J. , Walsh Catherine , Bosman Arthur D. , Guzmán Viviana V. , Gal Romane Le , Öberg Karin I. , Yamato Yoshihide , Aikawa Yuri , Andrews Sean M. , Bae Jaehan , Bergin Edwin A. , Bergner Jennifer B. , Cleeves L. Ilsedore , Kurtovic Nicolas T. , Ménard François , Nomura Hideko , Pérez Laura M. , Qi Chunhua , Schwarz Kamber R. , Tsukagoshi Takashi , Waggoner Abygail R. , Wilner David J. , Zhang Ke 
Published: November 2021

Abstract
The Molecules with ALMA at Planet-forming Scales Large Program (MAPS LP) surveyed the chemical structures of five protoplanetary disks across more than 40 different spectral lines at high angular resolution (0.″15 and 0.″30 beams for Bands 6 and 3, respectively) and sensitivity (spanning 0.3–1.3 mJy beam−1 and 0.4–1.9 mJy beam−1 for Bands 6 and 3, respectively). In this article, we describe the multistage workflow—built around the CASA tclean image deconvolution procedure—that we used to generate the core data product of the MAPS LP: the position–position–velocity image cubes for each spectral line. Owing to the expansive nature of the survey, we encountered a range of imaging challenges: some are familiar to the submillimeter protoplanetary disk community, like the need to use an accurate CLEAN mask, and others are less well known, like the incorrect default flux scaling of the CLEAN residual map first described by Jorsater & van Moorsel (the “JvM effect”). We distill lessons learned into recommended workflows for synthesizing image cubes of molecular emission. In particular, we describe how to produce image cubes with accurate fluxes via “JvM correction,” a procedure that is generally applicable to any image synthesized via CLEAN deconvolution but is especially critical for low signal-to-noise ratio (S/N) emission. We further explain how we used visibility tapering to promote a common, fiducial beam size and contextualize the interpretation of S/N when detecting molecular emission from protoplanetary disks. This paper is part of the MAPS special issue of the Astrophysical Journal Supplement.
Molecules with ALMA at Planet-forming Scales (MAPS). XIV. Revealing Disk Substructures in Multiwavelength Continuum Emission
Authors: Sierra Anibal , Pérez Laura M. , Zhang Ke , Law Charles J. , Guzmán Viviana V. , Qi Chunhua , Bosman Arthur D. , Öberg Karin I. , Andrews Sean M. , Long Feng , Teague Richard , Booth Alice S. , Walsh Catherine , Wilner David J. , Ménard François , Cataldi Gianni , Czekala Ian , Bae Jaehan , Huang Jane , Bergner Jennifer B. , Ilee John D. , Benisty Myriam , Le Gal Romane , Loomis Ryan A. , Tsukagoshi Takashi , Liu Yao , Yamato Yoshihide , Aikawa Yuri 
Published: November 2021

Abstract
Constraining dust properties of planet-forming disks via high-angular-resolution observations is fundamental to understanding how solids are trapped in substructures and how dust growth may be favored or accelerated therein. We use ALMA dust continuum observations of the Molecules with ALMA at Planet-forming Scales (MAPS) disks and explore a large parameter space to constrain the radial distribution of solid mass and maximum grain size in each disk, including or excluding dust scattering. In the nonscattering model, the dust surface density and maximum grain size profiles decrease from the inner disks to the outer disks, with local maxima at the bright ring locations, as expected from dust trapping models. The inferred maximum grain sizes from the inner to outer disks decrease from 1 cm to 1 mm. For IM Lup, HD 163296, and MWC 480 in the scattering model, two solutions are compatible with their observed inner disk emission: one solution corresponding to a maximum grain size of a few millimeters (similar to the nonscattering model), and the other corresponding to a size of a few hundred micrometers. Based on the estimated Toomre parameter, only IM Lup—which shows a prominent spiral morphology in millimeter dust—is found to be gravitationally unstable. The estimated maximum Stokes number in all the disks lies between 0.01 and 0.3, and the estimated turbulence parameters in the rings of AS 209 and HD 163296 are close to the threshold where dust growth is limited by turbulent fragmentation. This paper is part of the MAPS special issue of the Astrophysical Journal Supplement.
Molecules with ALMA at Planet-forming Scales. XX. The Massive Disk around GM Aurigae
Authors: Schwarz Kamber R. , Calahan Jenny K. , Zhang Ke , Alarcón Felipe , Aikawa Yuri , Andrews Sean M. , Bae Jaehan , Bergin Edwin A. , Booth Alice S. , Bosman Arthur D. , Cataldi Gianni , Cleeves L. Ilsedore , Czekala Ian , Huang Jane , Ilee John D. , Law Charles J. , Le Gal Romane , Liu Yao , Long Feng , Loomis Ryan A. , Macías Enrique , McClure Melissa , Ménard François , Öberg Karin I. , Teague Richard , van Dishoeck Ewine , Walsh Catherine , Wilner David J. 
Published: November 2021

Abstract
Gas mass remains one of the most difficult protoplanetary disk properties to constrain. With much of the protoplanetary disk too cold for the main gas constituent, H2, to emit, alternative tracers such as dust, CO, or the H2 isotopologue HD are used. However, relying on disk mass measurements from any single tracer requires assumptions about the tracer’s abundance relative to H2 and the disk temperature structure. Using new Atacama Large Millimeter/submillimeter Array (ALMA) observations from the Molecules with ALMA at Planet-forming Scales (MAPS) ALMA Large Program as well as archival ALMA observations, we construct a disk physical/chemical model of the protoplanetary disk GM Aur. Our model is in good agreement with the spatially resolved CO isotopologue emission from 11 rotational transitions with spatial resolution ranging from 0.″15 to 0.″46 (24–73 au at 159 pc) and the spatially unresolved HD J = 1–0 detection from Herschel. Our best-fit model favors a cold protoplanetary disk with a total gas mass of approximately 0.2 M
⊙, a factor of 10 reduction in CO gas inside roughly 100 au and a factor of 100 reduction outside of 100 au. Despite its large mass, the disk appears to be on the whole gravitationally stable based on the derived Toomre Q parameter. However, the region between 70 and 100 au, corresponding to one of the millimeter dust rings, is close to being unstable based on the calculated Toomre Q of <1.7. This paper is part of the MAPS special issue of the Astrophysical Journal Supplement.