bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of perceived labor market conditions in employees’ turnover intention model – mediation and moderation analyzes
Authors: Bhat Mohd Abass , Tariq Khan Shagufta , Rainayee Riyaz Ahmad 
Published: March 2021

Purpose
This paper aims to examine employee perceptions of the labor market in the employee turnover intention model and explores how different situations outside work (labor market conditions) play a role in employee-organizational membership. In addition, it also examines the mediating role of commitment in the relationship between stress and the turnover model.

Design/methodology/approach
Data were collected from 628 private school teachers working in the economically depressed state of J&K (India), which were randomly selected. Confirmatory factor analysis was used for validation of a scale. Structural equation modeling and PROCESS by Hayes was used to test the hypothesized relationships between the study variables.

Findings
The antecedents of occupational stressors contribute negatively toward employees’ psychological state resulting in undesirable employee-organizational relationships such as high turnover intentions and low organizational commitment. Nevertheless, lack of external job opportunities compels employees to maintain organizational membership, even though against the stressful working environment.

Research limitations/implications
This study while acknowledging the inherent limitations, questionnaires are susceptible to and single sectional nature of the study poses limitations.

Practical implications
The practical implication explains that the employee and organization relationship is governed more by external economic conditions than by the psychological feelings of the employees toward the organization (organizational commitment). As also, the moral system of employees, as well as their feelings toward the noble profession makes them feel morally exalted and this binds them to the membership of the organization.

Originality/value
This study mainly focuses on, to understand if and how the conditions of the labor market relate to the employees’ attitudes. This would enable us to gain more insights to the systematic relations of employees’ attitudinal variables such as occupational stress, organizational commitment and employee turnover intentions.
Real estate investors’ behaviour
Authors: Abdallah Mohamad Hussein Ismail , Al-Tamimi Hussein A. Hassan , Duqi Andi 
Published: March 2021

Purpose
This paper aims to investigate perceptions of United Arab Emirates (UAE) real estate investors’ behaviour and the factors that most influence their investment decisions.

Design/methodology/approach
This study used a modified questionnaire that was divided into two parts. The first part covered demographic and socioeconomic variables. The second part identified 36 factors that affect the perceptions of real estate investors in the UAE regarding their investment decisions. These factors were placed in eight different categories that correspond to non-personal factors such as, profit, market conditions, risk, transparency, credit facilities (loans), infrastructure and services.

Findings
The findings confirm that there is a significant and positive relationship between three factors; namely, profitability, risk and service quality regarding investments in the real estate sector. The findings also confirm a positive but statistically insignificant relationship between transparency, market conditions, credit facilities, infrastructure and investment in the UAE’s real estate sector.

Research limitations/implications
The sample size represents one of the limitations of this study. In addition, the gender of the sample is another limitation as, in general, men are more involved in investment than women are. Furthermore, there are no previous studies regarding the behaviour of UAE real estate investors; thus, the findings of this study cannot be directly compared with other empirical studies.

Practical implications
It might be helpful to create separate units under the name “Real Estate Information Unit” in every municipality of each of the seven emirates. In addition, it is recommended that decision makers should consider ensuring that modern high-quality real estate infrastructure is available to attract more investors. Finally, minimizing any restrictions on access financing facilities may encourage investors to invest more in the UAE real estate sector.

Originality/value
This study is the first of its kind to be conducted in the context of the behaviour of UAE real estate investors.
“Practicing care in qualitative organizational research: moral responsibility and legitimacy in a study of immigration management”
Authors: Okkonen Ida , Takala Tuomo , Bell Emma 
Published: March 2021

PurposeThe purpose of this paper is to provide insight into the reciprocal relations between the caregiving imparted by immigration centre managers and the role of the researcher in responding to the care that is given by managerial caregivers. To enable this, we draw on a feminist theory of care ethics that considers individuals as relationally interdependent.Design/methodology/approachThe analysis draws on a semi-structured interview study involving 20 Finnish immigration reception centre managers.FindingsInsight is generated by reflecting on moments of care that arise between research participants and the researcher in a study of immigration centre management. We emphasise the importance of mature care, receptivity and engrossment in building caring relationships with research participants by acknowledging the care they give to others. Our findings draw attention to the moral and epistemological responsibility to practice care in organizational research.Originality/valueThe paper highlights the relationality between practicing care in immigration centre management and doing qualitative organizational research, both of which rely on mature care, receptivity and engrossment in order to meet the other morally. We draw attention to the moral responsibility to care which characterises researcher–researched relationships and emphasise the importance of challenging methodological discourses that problematise or dismiss care in qualitative organizational research.
Body size and shape responses to warming and resource competition
Authors: Tan Hanrong , Hirst Andrew G. , Atkinson David , Kratina Pavel 
Published: March 2021

Abstract

Body size is a fundamental trait that impacts many aspects of species biology and ecology. It is, in turn, influenced by a suite of environmental factors, and often decreases with warming. Although environmental conditions can also impact body shape, which is another functional trait that influences locomotion, resource acquisition and potentially physiological processes, such responses are poorly understood and rarely quantified.

We experimentally tested the independent and combined effects of environmental temperature, resource level and interspecific competition on the body shape and size responses of two model protist species. We also tested the degree to which these individual‐level phenotypic responses are associated with population densities and species coexistence.

Body shape was strongly influenced by resource competition, whereas body size changes were mainly driven by environmental temperature. In both species, lower resource levels resulted in body shape elongation, suggesting that relatively more elongate individuals with potentially higher swimming speed were advantaged in the resource scarce environment. However, competition had contrasting influence on the body shape of the two species. Competition decreased the population densities of Blepharisma japonicum, which exhibited relative body shape elongation, similar to the response at low resource levels. In contrast, competition increased the population densities of Paramecium aurelia, which exhibited reduced elongation similar to body shape response at high resource levels. Hence, body shape responses could be indicative of changes in resource availability, aiding our understanding of competitive hierarchies and species interactions.

Coexistence was observed in all treatment combinations, likely because body size of both species decreased similarly under warming, potentially maintaining constant per capita competitive intensity. These findings, along with recent research on phytoplankton, diverse pelagic invertebrates, and birds highlight the importance of body shape and morphology across different taxonomic groups. Hence, we call for body size and shape to be considered in concert when investigating ecological consequences of climate warming.

A free Plain Language Summary can be found within the Supporting Information of this article.
Conservative management of spontaneous intra‐abdominal abscess in Crohn's disease: Outcome and prognostic factors
Authors: Waked Bruno , Holvoet Tom , Geldof Jeroen , Baert Filip , Pattyn Piet , Lobatón Triana , Hindryckx Pieter 
Published: March 2021

ObjectiveTo compare the outcomes of different treatments for spontaneous intra‐abdominal abscesses (IAA) in active Crohn's disease (CD).MethodsA retrospective analysis of patients with CD between January 2007 and December 2018 was performed in two Belgian inflammatory bowel disease centers. Successful conservative management was defined as complete resolution of abscesses without the need for bowel resection. The primary outcome was suboptimal evolution, defined as a composite outcome of recurrence of abscess, postoperative complications or the need for a non‐elective resection.ResultsForty CD patients presenting with 43 independent episodes of spontaneous IAA development were included. One underwent immediate bowel resection. In all other 42 cases a conservative approach was taken, which led to a complete abscess resolution rate of 28.6% (12/42). The remaining abscesses required bowel resection. Anti‐tumor necrosis factor (TNF) agent use was associated with successful conservative management (odds ratio [OR] 13.36, 95% confidence interval [CI] 11.19‐15.52, P = 0.006), while the opposite trend was found for corticosteroids (OR 0.14, 95% CI 0.02‐1.26, P = 0.055). There was a trend towards suboptimal evolution in case of previous bowel resection (OR 4.77, 95% CI 0.77‐29.66, P = 0.094) or in patients aged above 50 years (OR 5.17, 95% CI 0.86‐30.91, P = 0.072).ConclusionsBowel resection appears to be inevitable in most CD patients presenting with IAA. An attempt at conservative treatment may be particularly successful with anti‐TNF agents in younger patients who have not undergone previous bowel resection. Large‐scale prospective studies are needed to confirm these findings.
GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells
Authors: Zhang Minfa , Yang Xiaoqi , Chen Shuai , Jia Wenming , Ma Xiaojie , Wang Juan , Qian Ye , Lei Dapeng , Liu Heng , Pan Xinliang 
Published: March 2021

AbstractBackgroundG protein‐coupled receptor 12 (GPR12) is an orphan receptor with no confirmed endogenous ligands. It plays important roles in both physiological and pathological conditions such as neurogenesis and neural inflammation. However, it remains unclear whether GPR12 regulates carcinogenesis and progression in head and neck squamous cell carcinoma (HNSCC), such as esophageal cancer (EC) and hypopharyngeal cancer (HC).MethodsThe Cancer Genome Atlas (TCGA) database was applied to explore the expression of GPR12. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was used to detect the expression of GPR12 in cancer tissues. Wound healing and transwell assays were carried out to verify the effect of GPR12 on cell migration. Flow cytometric analysis and caspase‐Glo 3/7 assay were carried out to verify the influence of GPR12 on cell apoptosis. Western blotting was used to measure the expression of proteins related to migration and apoptosis.ResultThe qRT‐PCR analyses showed that the expression of GPR12 decreased in EC and HC than that in their paired adjacent normal tissues. Wound healing assay and transwell assay demonstrated that GPR12 inhibited tumor cell migration. Flow cytometry analysis and Caspase‐Glo 3/7 Assay suggested that GPR12 promoted apoptosis. The mechanism of GPR12 may function via modulating caspase‐7, E‐cadherin, and α‐catenin in EC and HC cells.ConclusionIn conclusion, GPR12 induced apoptosis by activating caspase‐7 and inhibited migration through epithelial‐to‐mesenchymal transition (EMT) in EC and HC. Our findings demonstrated that GPR12 as a potential tumor suppressor mediated cell migration and apoptosis in EC and HC.
Effects of moderate alcohol levels on default mode network connectivity in heavy drinkers
Authors: Fang Xiaojing , Deza‐Araujo Yacila I. , Petzold Johannes , Spreer Maik , Riedel Philipp , Marxen Michael , O’Connor Sean J. , Zimmermann Ulrich S. , Smolka Michael N. 
Published: March 2021

AbstractBackgroundIt is well established that even moderate levels of alcohol affect cognitive functions such as memory, self‐related information processing, and response inhibition. Nevertheless, the neural mechanisms underlying these alcohol‐induced changes are still unclear, especially on the network level. The default mode network (DMN) plays an important role in memory and self‐initiated mental activities; hence, studying functional interactions of the DMN may provide new insights into the neural mechanisms underlying alcohol‐related changes.MethodsWe investigated resting‐state functional connectivity (rsFC) of the DMN in a cohort of 37 heavy drinkers at a breath alcohol concentration of 0.8 g/kg. Alcohol and saline were infused in a single‐blind crossover design.ResultsIntranetwork connectivity analyses revealed that participants showed significantly decreased rsFC of the right hippocampus and right middle temporal gyrus during acute alcohol exposure. Moreover, follow‐up analyses revealed that these rsFC decreases were more pronounced in participants who reported stronger craving for alcohol. Exploratory internetwork connectivity analyses of the DMN with other resting‐state networks showed no significant alcohol‐induced changes, but suffered from low statistical power.ConclusionsOur results indicate that acute alcohol exposure affects rsFC within the DMN. Functionally, this finding may be associated with impairments in memory encoding and self‐referential processes commonly observed during alcohol intoxication. Future resting‐state functional magnetic resonance imaging studies might therefore also investigate memory function and test whether DMN‐related connectivity changes are associated with alcohol‐induced impairments or craving.
Blau syndrome with pulmonary nodule in a child
Authors: Su Jinping , Liu Donghua 
Published: March 2021

AbstractBlau syndrome (BS) is a rare monogenic disease caused by mutation of NOD2/CARD15 gene. A case of Blau syndrome in a 4‐year‐old Chinese boy c.1001G > A(p.R334Q) mutation in the NOD2 genes reported. Imaging revealed a nodule at the tip of the right lung.
Association between electrocardiographic features and mortality in COVID‐19 patients
Authors: Antwi‐Amoabeng Daniel , Beutler Bryce D. , Singh Sahajpreet , Taha Moutaz , Ghuman Jasmine , Hanfy Ahmed , Manasewitsch Nicholas T. , Ulanja Mark B. , Ghuman Joban , Awad Munadel , Gullapalli Nageshwara , Gbadebo T. David 
Published: March 2021

AbstractBackgroundCardiovascular events have been reported in the setting of coronavirus disease‐19 (COVID‐19). It has been hypothesized that systemic inflammation may aggravate arrhythmias or trigger new‐onset conduction abnormalities. However, the specific type and distribution of electrocardiographic disturbances in COVID‐19 as well as their influence on mortality remain to be fully characterized.MethodsElectrocardiograms (ECGs) were obtained from 186 COVID‐19‐positive patients at a large tertiary care hospital in Northern Nevada. The following arrhythmias were identified by cardiologists: sinus bradycardia, sinus tachycardia, atrial fibrillation (A‐Fib), atrial flutter, multifocal atrial tachycardia (MAT), premature atrial contraction (PAC), premature ventricular contraction (PVC), atrioventricular block (AVB), and right bundle branch block (RBBB). The mean PR interval, QRS duration, and corrected QT interval were documented. Fisher's exact test was used to compare the ECG features of patients who died during the hospitalization with those who survived. The influence of ECG features on mortality was assessed with multivariable logistic regression analysis.ResultsA‐Fib, atrial flutter, and ST‐segment depression were predictive of mortality. In addition, the mean ventricular rate was higher among patients who died as compared to those who survived. The use of therapeutic anticoagulation was associated with reduced odds of death; however, this association did not reach statistical significance.ConclusionThe underlying pathogenesis of COVID‐19‐associated arrhythmias remains to be established, but we postulate that systemic inflammation and/or hypoxia may induce potentially lethal conduction abnormalities in affected individuals. Longitudinal studies are warranted to evaluate the risk factors, pathogenesis, and management of COVID‐19‐associated cardiac arrhythmias.
Operative experience in essential emergency general surgery procedures: is autonomy achievable during surgical training?
Authors: Belvedere Shane , Joh Daniel , Furlong Tim , Dennett Elizabeth , Loveday Benjamin P. T. 
Published: March 2021

AbstractBackgroundReadiness for practice is an ongoing concern in surgery. Surgeons who have completed general surgery training are expected to be proficient in performing common emergency procedures. The aim of this study was to assess the experience and autonomy of general surgery trainees in New Zealand in 10 emergency general surgery procedures, and identify factors associated with reaching primary operator (PO) thresholds.MethodsOperative logbook data from all New Zealand general surgery trainees from 2013 to 2017 were analysed. Data for 10 emergency general surgery procedures were extracted to determine PO and autonomous PO (mentor not scrubbed) rates. A threshold of 70% for PO and APO rates was used to define two levels of proficiency.ResultsA total of 120 trainees performed 40 865 included procedures. Trainees met the PO threshold for all procedures by Surgical Education and Training (SET) 5. The APO threshold was met for three of 10 procedures (appendicectomy, drainage of perianal abscess and perforated peptic ulcer repair). Final APO rates for the other procedures ranged from 18% to 58%. On multivariate analysis, SET year and case volume were associated with increased odds of meeting the PO and APO thresholds. Female trainees were less likely to reach the PO and APO thresholds for three of 10 and four of 10 procedures, respectively.ConclusionTrainees had increasing PO and autonomous PO rates over the course of their training. Graduating New Zealand general surgeons likely have sufficient operative experience in emergency general surgery procedures. However, rates of autonomy are lower, and further research is needed to determine whether this affects readiness for independent practice.
Plasma long‐chain omega‐3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study
Authors: Goodfellow Laura , Care Angharad , Harrold Jane , Sharp Andrew , Ivandic Jelena , Poljak Borna , Roberts Devender , Alfirevic Ana , Müller‐Myhsok Bertram , Gibson Robert , Makrides Maria , Alfirevic Zarko 
Published: March 2021

AbstractIntroductionA 2018 Cochrane review found that omega‐3 supplementation in pregnancy was associated with a risk reduction of early preterm birth of 0.58; prompting calls for universal supplementation. Recent analysis suggests the benefit may be confined to women with a low baseline omega‐3 fatty acid status. However, the contemporary omega‐3 fatty acid status of pregnant women in the UK is largely unknown. This is particularly pertinent for women with a previous preterm birth, in whom a small relative risk reduction would have a larger reduction of absolute risk. This study aimed to assess the omega‐3 fatty acid status of a UK pregnant population and determine the association between the long‐chain omega‐3 fatty acids and recurrent spontaneous early preterm birth.Material and methodsA total of 283 high‐risk women with previous early preterm birth were recruited to the prospective observational study in Liverpool, UK. Additionally, 96 pregnant women with previous term births and birth ≥39+0 weeks in the index pregnancy provided a low‐risk population sample. Within the high‐risk group we assessed the odds ratio of recurrent early preterm birth compared with birth at ≥37+0 weeks of gestation according to plasma eicosapentaenoic acid plus docosahexaenoic acid (EPA+DHA) at 15–22 weeks of gestation.ResultsOur participants had low EPA+DHA; 62% (143/229) of women with previous preterm birth and 69% (68/96) of the population sample had levels within the lowest two quintiles of a previously published pregnancy cohort. We found no association between long‐chain omega‐3 status and recurrent early preterm birth (n = 51). The crude odds ratio of a recurrent event was 0.91 (95% CI 0.38–2.15, p = 0.83) for women in the lowest, compared with the highest three quintiles of EPA+DHA.ConclusionsIn the majority of our participants, levels of long‐chain omega‐3 were low; within the range that may benefit from supplementation. However, levels showed no association with risk of recurrent early spontaneous preterm birth. This could be because our population levels were too low to show benefit in being omega‐3 “replete”; or else omega‐3 levels may be of lesser importance in recurrent early preterm birth.
Ranibizumab in retinopathy of prematurity – one‐year follow‐up of ophthalmic outcomes and two‐year follow‐up of neurodevelopmental outcomes from the CARE‐ROP study
Authors: Stahl Andreas , Bründer Marie‐Christine , Lagrèze Wolf A. , Molnár Fanni E. , Barth Teresa , Eter Nicole , Guthoff Rainer , Krohne Tim U. , Pfeil Johanna M. ,   the CARE‐ROP Study Group
Published: March 2021

AbstractPurposeThe primary endpoint results from the comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity (CARE‐ROP) core study identified ranibizumab as an effective treatment to control acute retinopathy of prematurity (ROP). This study reports the 1‐ and 2‐year follow‐up data focusing on long‐term functional outcomes and safety.MethodsThe CARE‐ROP trial compared 0.12 mg versus 0.20 mg ranibizumab in 20 infants with ROP in a multicentric, prospective, randomized, double‐blind, controlled study design. Sixteen patients entered the follow‐up period. An ophthalmologic assessment at one year postbaseline was acquired from all 16 patients and a neurodevelopmental assessment at two years postbaseline was acquired from 15 patients.ResultsFifteen of 16 infants were able to fixate and follow moving objects at one year postbaseline treatment. One child progressed to stage 5 ROP bilaterally between the end of the core study and the 1‐year follow‐up (first seen at PMA 75 weeks). Mean spherical equivalents were −1.9 diopters (D) and −0.75 D in the 0.12 mg and the 0.20 mg treatment arms. Strabismus was present in seven and nystagmus in five out of 16 infants. Mental development scores were within normal limits in six out of ten patients with available data. No statistically significant difference was observed between the two treatment arms.ConclusionNeurodevelopmental and functional ocular outcomes 1 and 2 years after treatment with ranibizumab are reassuring regarding long‐term safety. Late reactivation of ROP, however, represents a challenge during the follow‐up phase and it is of utmost importance that regular follow‐ups are maintained.