bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eastern Africa and the Early Indian Ocean: Understanding Mobility in a Globalising World
Authors: Horton Mark , Boivin Nicole , Crowther Alison 
Published: February 2021

Abstract
This paper situates Eastern Africa in the early maritime trade of the Indian Ocean, reviewing evidence for connections from Egypt and Red Sea, the Gulf, and Southeast Asia from prehistory to the Islamic Period. The region played a pivotal role in developing global networks, but we argue that it has become the “forgotten south” in an era of emerging empires. One reason for this is a lack of understanding of maritime mobility around the rim of the Indian Ocean, often undertaken by small scale or specialist groups, including sea nomads. These groups are characterised as marginalised and victimised during globalisation, yet dualising into categories—such as “exploiter” and “exploiting”—oversimplifies what was almost certainly in reality a complex array of roles and activities, both in the context of East Africa and elsewhere around the Indian Ocean. Through modern scientific-based excavation and analysis, we can now begin to more fully understand these interactions.
The Interrelation between Public Participation and Access to Justice in the eia Context in the Face of the Increasing Use of Digital Technologies: Comment on the cjeu Judgment in the A.Flausch et al Case (C-280/18)
Authors: Karageorgou Vasiliki (Vicky) 
Published: February 2021

Abstract
The article analyzes the cjeu Judgment in the A. Flausch et al case, which concerns the compatibility of the Greek procedural rules relating to specific aspects of the public participation in the eia context and to a specific aspect of access to justice (time limit) with the respective EU Law provisions in the face of the increasing use of digital technologies in the public participation procedures. This ruling is important, because it sets limits to the procedural autonomy of ms when it comes to the rules that are applied to the eia-related disputes and those that concern the public participation arrangements. It demonstrates, though, the lack of a steady line in the Court’s jurisprudence concerning the standards for assessing the national procedural rules and the role of Article 47 cfr. Moreover, the Court did not lay the ground for an interpretation of the ΕU public participation provisions in a way that an obligation for taking measures could be established, with the aim to ensure equal participation opportunities.
A Lost Opportunity? The Environment and the EU – Mercosur Trade Agreement
Authors: Krämer Ludwig 
Published: February 2021

Abstract
The present contribution analyses and demonstrates where the EU – Mercosur Trade Agreement is incomplete with regard to the protection of the environment and where it could usefully be improved. Most importantly, this contribution shows that the sketchy and not complete examination of environmental provisions, which could usefully be part of the EU – Mercosur Agreement, demonstrates that this Agreement is not aiming at sustainable development with regard to the protection of the environment.
Scribner’s Bookstore
Authors: Emblidge David 
Published: February 2021

Abstract
In 1989, a literary landmark in New York City closed. Scribner’s Bookstore, 597 Fifth Avenue, stood at the epicentre of Manhattan’s retail district. The Scribner’s publishing company was then 153 years old. In the 1920s, driven by genius editor Max Perkins, Scribner’s published Fitzgerald, Hemingway, and Wolfe. Scribner’s Magazine was The New Yorker of its day. The bookshop and publisher occupied a 10-storey Beaux-Arts building, designed by Ernest Flagg, which eventually won protection from the New York City Landmarks Preservation Commission. Medallions honoured printers Benjamin Franklin, William Caxton, Johann Gutenberg, and Aldus Manutius. The ‘Byzantine cathedral of books’ offered deeply informed personal service. But the paperback revolution gained momentum, bookshop chains like Barnes & Noble and Brentano’s adopted extreme discounting, and the no-discounting Scribner’s business model became unsustainable. Real estate developers swooped in. The bookshop’s ignominious end came when Italian clothier Benetton took over its space.
The Impact of the Stratospheric Polar Vortex Shift on the Arctic Oscillation
Authors: Lu Yongjia , Tian Wenshou , Zhang Jiankai , Huang Jinlong , Zhang Ruhua , Wang Tao , Xu Mian 
Published: February 2021

AbstractUsing the ERA-Interim reanalysis dataset for the time period 1979–2016, we analyzed the influence of the stratospheric polar vortex shift on the Arctic Oscillation (AO) in winter (December–March). The results show that a shift in the stratospheric polar vortex toward the Eurasian continent is favorable for the occurrence of the negative phase of the AO. The duration of the AO events accompanied by the stratospheric polar vortex shift toward the Eurasian continent (AO-shift events) is longer than that of the remaining negative AO events (AO-noshift events), and the intensity of AO-shift events is greater than that of AO-noshift events from day 4 to day 15 of the life cycle of the events. The enhancement in the AO intensity during AO-shift events is likely due to downward extension of the stratospheric northern annular mode (NAM) signals and more poleward-propagating planetary waves in the troposphere and lower stratosphere and their convergence in the mid-high latitudes. Furthermore, the polar vortex shift can lead to changes in the intensity of the three action centers in the AO spatial pattern at 500 hPa. In general, during AO-shift events, the three action centers are stronger than those during AO-noshift events. There is an overall westward shift of the Arctic action center during AO-shift events, which may be closely related to the changes of Greenland blocking frequency.
The Value of Long-Term Streamflow Forecasts in Adaptive Reservoir Operation: The Case of the High Aswan Dam in the Transboundary Nile River Basin
Authors: Eldardiry Hisham , Hossain Faisal 
Published: February 2021

AbstractTransboundary river basins are experiencing extensive dam development that challenges future water management, especially for downstream nations. Thus, adapting the operation of existing reservoirs is indispensable to cope with alterations in flow regime. We proposed a Forecast-Based Adaptive Reservoir Operation (FARO) framework to evaluate the use of long-term climate forecasts in improving real-time reservoir operations. The FARO approach was applied to the High Aswan Dam (HAD) in the Nile River basin. Monthly precipitation and temperature forecasts at up to 12 months of lead time are used from a suite of eight North American Multi-Model Ensemble (NMME) models. The value of NMME-based forecasts to reservoir operations was compared with perfect and climatology-based forecasts over an optimization horizon of 10 years from 1993 to 2002. Our results indicated that the forecast horizon for HAD operation ranges between 5 and 12 months lead time at low- and high-demand scenarios, respectively, beyond which the forecast information no longer improves the release decision. The forecast value to HAD operation is more pronounced in the months following the flooding season (October–December). During these months, the skill of streamflow forecasts using NMME forcings outperforms the climatology-based forecasts. When considering the operation of upstream Grand Ethiopian Renaissance Dam (GERD), using streamflow forecasts minimally helps to maintain current target objectives of HAD operation and therefore result in higher operation costs as opposed to current conditions without GERD. Our study underlined the importance of deriving a new adaptive operating policy for HAD to improve the value of available forecasts while considering GERD filling and operation phases.
Receipt of and Spending on Cessation Medication Among US Adults With Employer-Sponsored Health Insurance, 2010 and 2017
Authors: Shrestha Sundar S. , Xu Xin , Wang Xu , Babb Stephen D. , Armour Brian S. , King Brian A. , Trivers Katrina F. 
Published: February 2021

Objective Studies examining the use of smoking cessation treatment and related spending among enrollees with employer-sponsored health insurance are dated and limited in scope. We assessed changes in annual receipt of and spending on cessation medications approved by the US Food and Drug Administration (FDA) among tobacco users with employer-sponsored health insurance from 2010 to 2017. Methods We analyzed data on 439 865 adult tobacco users in 2010 and 344 567 adult tobacco users in 2017 from the IBM MarketScan Commercial Database. We used a negative binomial regression to estimate changes in receipt of cessation medication (number of fills and refills and days of supply). We used a generalized linear model to estimate spending (total, employers’, and out of pocket). In both models, covariates included year, age, sex, residence, and type of health insurance plan. Results From 2010 to 2017, the percentage of adult tobacco users with employer-sponsored health insurance who received any cessation medication increased by 2.4%, from 15.7% to 16.1% ( P < .001). Annual average number of fills and refills per user increased by 15.1%, from 2.5 to 2.9 ( P < .001) and days of supply increased by 26.4%, from 81.9 to 103.5 ( P < .001). The total annual average spending per user increased by 53.6%, from $286.40 to $440.00 ( P < .001). Annual average out-of-pocket spending per user decreased by 70.9%, from $70.80 to $20.60 ( P < .001). Conclusions Use of smoking cessation medications is low among smokers covered by employer-sponsored health insurance. Opportunities exist to further increase the use of cessation medications by promoting the use of evidence-based cessation treatments and reducing barriers to coverage, including out-of-pocket costs.
Examining Racial Differences in the Informal Discussion of Advance Care Planning Among Older Adults: Application of the Andersen Model of Health Care Utilization
Authors: Suntai Zainab , Noh Hyunjin , Won Cho Rong 
Published: February 2021

Objectives: The purpose of this study was to examine racial differences in the discussion of advance care planning among older adults using Andersen’s behavioral model of health care utilization. Method: This cross-sectional study utilized data from the 2018 National Health and Aging Trends Study. Weighted multivariable logistic regressions were used to predict advance care planning discussion ( n = 1,326). Results: After accounting for predisposing, enabling, and need factors, Black older adults were less likely to discuss end-of-life care (odds ratio [OR] = .527) and medical power of attorney (OR = .531) compared with Whites. Hispanic older adults were also less likely to discuss end-of-life care (OR = .389) and power of attorney (OR = .384) compared with Whites. Discussion: These results point to significant racial disparities in advance care planning discussions among older adults and call for future examinations of cultural, historical, and systemic factors that could influence the discussion of advance care planning among this population.
Evaluation of a School-Based Child Physical and Sexual Abuse Prevention Program
Authors: Thompson Erika L. , Zhou Zhengyang , Garg Ashvita , Rohr Danielle , Ajoku Brittany , Spence Emily E. 
Published: February 2021

Background Evidence-based child sexual and physical abuse prevention programs delivered in schools are needed and require rigorous evaluation of program effects prior to widespread dissemination. The Play it Safe! program is a one-time session delivered by trained facilitators to teach students about recognizing, resisting, and reporting abuse. Aims To evaluate a school-based child sexual and physical abuse prevention intervention Play it Safe! among elementary school students using a cluster randomized design. Method Six elementary schools in Texas were matched on demographic characteristics, and then randomized to intervention or wait-list control groups. Participants included third to fifth graders ( n = 539). Participants received the pretest assessing vignette-based knowledge of physical and sexual abuse prevention (14 items). The intervention group immediately had the program. One month later, both groups received a posttest using the same validated scale. Multilevel linear regression analyses were estimated, and interaction effects were used to evaluate the effect of Play it Safe! while controlling for other factors. Results A statistically significant interaction between the treatment group and time ( b = 1.30, p < .01) indicated a greater increase in the knowledge score over time in the intervention group. Moderating effect of grade was also observed as the intervention tended to have less effect for fifth grade compared with third grade ( b = −1.04, p = .01). Conclusion This study provides evidence to support the efficacy of the Play it Safe! program for increasing children’s physical and sexual abuse prevention knowledge and skills among a racially and ethnically diverse sample of elementary school students.
Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome: A case report
Authors: Cifuentes-González Carlos , Amaris-Martínez Stefania , Reyes-Guanes Juliana , Uribe-Reina Pilar , de-la-Torre Alejandra 
Published: February 2021

Purpose: To present a rare and novel association of Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome. Case report: A 43-year-old Colombian female, presented with corneal ulcers, associated with trichiasis. At the ophthalmological examination forniceal shortening OU and symblepharon OD was found. Conjunctival biopsy was performed, evidencing linear deposition of IgG and IgA antibodies along the basement membrane of the conjunctiva, confirming Ocular Cicatricial Pemphigoid diagnosis. After 12 years, the patient presented constitutional symptoms, xerostomia, and worsening of xerophthalmia. Laboratory tests showed positive Anti-TG, Anti-TPO, Anti-Ro, and Anti-La antibodies, and salivary gland biopsy was consistent with Sjögren’s Syndrome. Due to these findings, Hashimoto’s Thyroiditis and Sjögren’s Syndrome were diagnosed, defining a Multiple Autoimmune Syndrome. Conclusion: A novel association of Multiple Autoimmune Syndrome is presented in this case. Ophthalmologists and other specialists involved in the evaluation and treatment of patients with autoimmune diseases, should be aware of this clinical presentation. A multidisciplinary approach in this condition is important for optimum treatment instauration and follow-up, in order to prevent complications.
Efficacy and safety of intravitreal aflibercept in ranibizumab-refractory patients with neovascular age-related macular degeneration
Authors: Razavi Sam , Kodjikian Laurent , Giocanti-Aurégan Audrey , Dufour Ingrid , Souied Eric 
Published: February 2021

Abstract
Background
Anti–vascular endothelial growth factor (anti-VEGF) agents have become the standard of care in neovascular age-related macular degeneration (nAMD). Despite generally excellent response rates to anti-VEGF therapy, some patients do not respond or may respond suboptimally. In the case of refractory or rapidly recurring fluid in nAMD, clinicians may switch to another anti-VEGF agent. TITAN was an observational study that assessed the effectiveness and safety of intravitreal aflibercept (IVT-AFL) in patients with nAMD refractory to ranibizumab who switched to IVT-AFL after less than 12 months of ranibizumab treatment in routine clinical practice in France.

Methods
TITAN was an observational, retrospective and prospective 12-month study conducted at 28 centres in France. Patients with nAMD refractory to ranibizumab were enrolled. Patients who were switched from ranibizumab to IVT-AFL were followed for 12 months. Data were obtained from medical records for retrospectively included patients, and at routine follow-up visits for those included prospectively. The main outcome measure was percentage of patients who achieved treatment success (gain of ≥1 Early Treatment Diabetic Retinopathy Study letters in best-corrected visual acuity [BCVA] and/or any reduction in central retinal thickness [CRT]) from baseline to 12 months after switching. A sample size of 225 patients was determined based on a 2-sided 95% confidence interval with a width equal to 0.12 when the sample proportion was 0.70.

Results
We analysed safety data (N = 217) and clinical outcomes from patients in the per-protocol population (n = 125). The mean (standard deviation) number of IVT-AFL injections was 7.5 (2.6). Treatment success was achieved in 68.8% of patients. Mean BCVA change from baseline to Month 12 was + 1.5 letters (P = 0.105) and the mean CRT change was − 45.0 μm (P <  0.001). In a subgroup analysis, in patients who received three initial monthly IVT-AFL injections, mean BCVA gain was 3.3 letters at Month 12 (P = 0.015). Excluding lack of efficacy and inappropriate scheduling of drug administration, the most common adverse event was eye pain (2.3%).

Conclusions
Switching ranibizumab-refractory patients with nAMD to IVT-AFL may improve visual outcomes in some patients, particularly those who receive three initial monthly injections.

Trial registration
ClinicalTrials.gov, NCT02321241. First posted: December 22, 2014; Last update posted: July 2, 2018
Pelvic organ prolapse and uterine preservation: a cohort study (POP-UP study)
Authors: Gagyor Daniel , Kalis Vladimir , Smazinka Martin , Rusavy Zdenek , Pilka Radovan , Ismail Khaled M. 
Published: February 2021

Abstract
Background
Abdominal and laparoscopic sacro-colpopexy (LSC) is considered the standard surgical option for the management of a symptomatic apical pelvic organ prolapse (POP). Women who have their uterus, and for whom an LSC is indicated, can have a laparoscopic sacro-hysteropexy (LSH), a laparoscopic supra-cervical hysterectomy and laparoscopic sacro-cervicopexy (LSCH + LSC) or a total laparoscopic hysterectomy and laparoscopic sacro-colpopexy (TLH + LSC). The main aim of this study was to compare clinical and patient reported outcomes of uterine sparing versus concomitant hysterectomy LSC procedures.

Methods
A retrospective analysis of clinical, imaging and patient reported outcomes at baseline, 3 and 12 months after LSH versus either LSCH + LSC or TLH + LSC between January 2015 and January 2019 in a tertiary referral urogynecology center in Pilsen, the Czech Republic.

Results
In total, 294 women were included in this analysis (LSH n = 43, LSCH + LSC n = 208 and TLH + LSC n = 43). There were no differences in the incidence of perioperative injuries and complications. There were no statistically significant differences between the concomitant hysterectomy and the uterine sparing groups in any of the operative, clinical or patient reported outcomes except for a significantly lower anterior compartment failure rate (p = 0.017) and higher optimal mesh placement rate at 12 months in women who had concomitant hysterectomy procedures (p = 0.006).

Conclusion
LSH seems to be associated with higher incidence of anterior compartment failures and suboptimal mesh placement based on postoperative imaging techniques compared to LSC with concomitant hysterectomy.
Systematic review of pragmatic randomised control trials assessing the effectiveness of professional pharmacy services in community pharmacies
Authors: Varas-Doval R. , Saéz-Benito L. , Gastelurrutia M. A. , Benrimoj S. I. , Garcia-Cardenas V. , Martinez-Martínez F. 
Published: February 2021

Abstract
Background
Implementation of Professional Pharmacy Services (PPSs) requires a demonstration of the service’s impact (efficacy) and its effectiveness. Several systematic reviews and randomised controlled trials (RCT) have shown the efficacy of PPSs in patient’s outcomes in community pharmacy. There is, however, a need to determine the level of evidence on the effectiveness of PPSs in daily practice by means of pragmatic trials.
To identify and analyse pragmatic RCTs that measure the effectiveness of PPSs in clinical, economic and humanistic outcomes in the community pharmacy setting.

Methods
A systematic search was undertaken in MEDLINE, EMBASE, the Cochrane Library and SCIELO. The search was performed on January 31, 2020. Papers were assessed against the following inclusion criteria (1) The intervention could be defined as a PPS; (2) Undertaken in a community pharmacy setting; (3) Was an original paper; (4) Reported quantitative measures of at least one health outcome indicator (ECHO model); (5) The design was considered as a pragmatic RCT, that is, it fulfilled 3 predefined attributes. External validity was analyzed with PRECIS- 2 tool.

Results
The search strategy retrieved 1,587 papers. A total of 12 pragmatic RCTs assessing 5 different types of PPSs were included. Nine out of the 12 papers showed positive statistically significant differences in one or more of the primary outcomes (clinical, economic or humanistic) that could be associated with the following PPS: Smoking cessation, Dispensing/Adherence service, Independent prescribing and MTM. No paper reported on cost-effectiveness outcomes.

Conclusions
There is limited available evidence on the effectiveness of community-based PPS. Pragmatic RCTs to evaluate clinical, humanistic and economic outcomes of PPS are needed.
High order algorithms for numerical solution of fractional differential equations
Authors: Asl Mohammad Shahbazi , Javidi Mohammad , Yan Yubin 
Published: February 2021

AbstractIn this paper, two novel high order numerical algorithms are proposed for solving fractional differential equations where the fractional derivative is considered in the Caputo sense. The total domain is discretized into a set of small subdomains and then the unknown functions are approximated using the piecewise Lagrange interpolation polynomial of degree three and degree four. The detailed error analysis is presented, and it is analytically proven that the proposed algorithms are of orders 4 and 5. The stability of the algorithms is rigorously established and the stability region is also achieved. Numerical examples are provided to check the theoretical results and illustrate the efficiency and applicability of the novel algorithms.