bluuebunny/crossref_metadata_2025_split huggingface dataset:
277 Tunable White Light for Elders (TWLITE): A feasibility study of a home-based sleep intervention
Authors: Jones Carolyn , Reynolds Christina , Olson Randall , Bontrager Ashten , Lambert Sophia , Balba Nadir , Weymann Kristianna , Kaye Jeffrey , Wilkerson Andrea , Elliott Jonathan , Lim Miranda 
Published: May 2021

Abstract

Introduction
Sleep disturbances are common in elderly patients and may contribute to disease progression in certain populations (e.g., Alzheimer’s Disease). Light therapy is a simple and cost-effective intervention to improve sleep. Primary barriers to light therapy are 1) poor acceptability to use of devices and 2) inflexibility of current devices to deliver beyond a fixed spectrum and throughout the entirety of the day. However, dynamic, tunable lighting integrated into the native home lighting system can maximize short-wavelength light in the morning and minimize short-wavelength light in the evening, thus entraining circadian rhythms and treating sleep disturbances, and overcome these limitations. We determined the feasibility of implementing a whole-home tunable lighting system as a potential sleep intervention.

Methods
Tunable LED lights were installed throughout the homes of healthy older adults already enrolled in an existing study with embedded home assessment platforms (ORCATECH study; n=4 subjects in n=3 homes). In ORCATECH, continuous data on room location, activity, sleep, and general health parameters are collected at minute-to-minute resolution over months to years of participation. This single arm longitudinal design collected participants’ light usage in addition to ORCATECH outcome measures. Primary outcomes for this pilot study included the feasibility and patient acceptability. Exploratory outcomes were sleep metrics (sleep time, latency, efficiency), mobility (room transitions and actigraphy), and overall health indices (weekly body weight, self-report general health questionnaires) both pre- and post-intervention.

Results
Two subjects terminated the study citing technical difficulties with the lights and a preference for brighter illumination. Of the remaining 2 participants, sleep metrics were explored over a 12-month period spanning pre- and post-installation of lights. Nightly duration in bed was compared with minute-to-minute room entry data and actigraphy with high inter-measure reliability.

Conclusion
These data support that tunable whole-home lighting systems are reasonably acceptable and feasibly implemented using an automated platform for continuous data collection. Quantification of sleep over long periods of time is robust and reliable in the home environment of elderly subjects. These results will inform implementation of future large-scale lighting intervention studies in patients at risk for developing Alzheimer’s Disease.

Support (if any)
Hartford Gerontological Center Interprofessional Award, Pacific Northwest National Laboratory, OHSU ORCATECH
283 Travel Factors in Away Games: A Case Study of a Women’s College Basketball Team
Authors: Pradhan Sean , Alton Devin 
Published: May 2021

Abstract

Introduction
Previous investigations in professional basketball, football, and other sports have shown meaningful effects of factors like rest and length of a team’s road trip on overall performance, with detriments being attributed to travel. However, prior research in the context of college basketball has been relatively scant. Thus, the current study extends the literature by performing a case study on the impact of such travel factors on a women’s college basketball team.

Methods
Data from a total of 110 road games played over the last 10 seasons from 2010 to 2020 by a National Association of Intercollegiate Athletics (NAIA) women’s college basketball team were collected from the college’s athletics site. We examined the influence of consecutive games played away, days in between games, back-to-back games, and miles traveled by the team on game outcomes and team performance. Specifically, we inspected box-score statistics, such as points scored, points allowed, shooting percentages (i.e., field-goal, free-throw, and three-point), rebounds, blocks, steals, assists, personal fouls, and turnovers. We performed a series of generalized regressions controlling for the team and opponent winning percentages entering each game, along with the opponent’s home time zone. Although neutral site games were excluded from our analyses, such events were still considered in determining the number of consecutive games played away from home.

Results
Our analyses revealed that the team scored significantly more points (p = .03), and won more games (p = .04) when traveling fewer miles away from their home city. We also found that fewer consecutive games played away were related to significantly more blocks of opponent shots (p = .02). Ultimately, the team shot significantly higher from the field when there were more days in between games (p = .03).

Conclusion
Findings from the present study reveal that certain aspects of team performance on the road appear to be influenced by miles traveled from the college’s home city, consecutive games played away, and days in between games. Results could be applied beyond the current context, whereby college basketball teams could utilize such findings to mitigate the impact of travel on athletes.

Support (if any)
None
301 Evaluation of Fatigue and Healthy Lifestyle Practices among New York State Law Enforcement Professionals
Authors: Endee Lisa , Rozensky Russell , Smith Stephen 
Published: May 2021

Abstract

Introduction
An important risk factor for drowsy driving is shift work, and law enforcement, an occupation known for its atypical work schedules, is a highly vulnerable occupation. A connection between fatigue and unintentional injuries among police officers has been observed (Vila, 2006), but data supporting the connection is limited. Understanding how sleep and lifestyle practices impact this population’s driving performance and job safety is critical to officer safety.

Methods
An online survey was disseminated to New York State law enforcement agencies by the Governor’s Traffic Safety Committee to assess sleep health and lifestyle practices among law enforcement personnel. Statistical analysis included data cleaning, basic and advanced statistical testing.

Results
7,366 survey invitations were distributed, 1,171 were returned (15.9% response rate), and after data cleaning, 1,038 surveys were included in the analysis. Respondents reported from various state, county, and local agencies, holding titles from Police Officer to Senior Management. More than 30% of officers reported driving 5 hours or more during their shift, with 12% driving greater than 7 hours. 65% of respondents reported having experienced drowsy driving. Although, 34% reported never having received education about drowsy driving. On work days, only 40% of respondents obtain 7 hours of sleep or more. On days off, 23.6% reported sleeping 6 hours or less. Work, stress, and family responsibilities were reported as having a significant impact on sleep. Almost 87% reported at least one medical issue. Daytime sleepiness (47.4%), fatigue (42.6%), and poor memory (26.8%) were reported daily. Only 23.8% and 29.3% of respondents received education on sleep or heart health, respectively. The majority (81.7%) reported they would consider education in a variety of health-related programs.

Conclusion
Our findings indicate that poor sleep (60%), high stress (22.7%), and anxiety (16.8%) are a concern amongst officers. Poor cardiovascular health was also noted, based on reports of obesity (34.1%), high blood pressure (23.5%), and high cholesterol (22.4%). This research supports the need for prioritizing health education programs within law enforcement agencies.

Support (if any)
Funded by The National Highway Traffic Safety Administration with a grant from The New York State Governor’s Traffic Safety Committee.
318 Area Deprivation and Sleep Health among White, Black, and Hispanic/Latina Women
Authors: Gaston Symielle , Lawrence Kaitlyn , Sandler Dale , Jackson Chandra 
Published: May 2021

Abstract

Introduction
Although neighborhood environments have been shown to affect sleep health, few studies have directly measured multiple indicators of both neighborhood deprivation and sleep while considering modification by race/ethnicity.

Methods
Among 49,833 eligible U.S. women enrolled in the Sister Study from 2003 to 2009, we investigated associations between neighborhood deprivation (e.g., percentage of residents unemployed, household crowding) and multiple sleep dimensions. Participants’ addresses were linked to U.S. census block group level Area Deprivation Index rankings (range: 1–100) for the year 2000, and participant rankings were divided into quintiles where the highest quintile represented the highest deprivation level. Participants self-reported habitual sleep duration, sleep debt, frequent napping, and insomnia symptoms. Adjusting for sociodemographic and clinical characteristics, we used Poisson regression with robust variance to estimate prevalence ratios (PRs) and 95% confidence intervals (CIs) for sleep dimensions among participants within quintiles (Qs) 2–5 vs. Q1. Interaction terms were used to assess modification by race/ethnicity.

Results
Mean age ± standard deviation was 55 ± 9 years. Women with higher neighborhood deprivation were more likely to self-identify as a racial/ethnic minority and had higher unadjusted prevalence of poor sleep dimensions. After adjustment, higher ADI was positively associated with very short sleep (≤5 hours), and race/ethnicity was a modifier (e.g., race-stratified results for Q5 vs. Q1:PRWhite=1.31 [95% CI: 1.14–1.51], PRBlack=0.91 [0.71–1.18], PRHispanic/Latina= 1.17 [0.68–2.04], p-interaction &lt;0.05). Although race/ethnicity did not modify remaining associations, women with higher neighborhood deprivation also had a higher prevalence of sleep debt, frequent napping, and insomnia symptoms. When compared to White women with the lowest neighborhood deprivation, Black women across all deprivation levels and Hispanic/Latina women in Q2-Q5 were substantially more likely to report each poor sleep dimension (PR range: 1.21 to 5.01).

Conclusion
A multidimensional measure of neighborhood deprivation was associated with poor sleep and sleep disparities among a diverse cohort of U.S. women.
Support (if any):
340 Improving maternal sleep via cognitive behavioral intervention: A randomised controlled trial from pregnancy to 2 years postpartum
Authors: Bei Bei , Pinnington Donna , Quin Nina , Shen Lin , Blumfield Michelle , Wiley Joshua , Drummond Sean , Newman Louise , Manber Rachel 
Published: May 2021

Abstract

Introduction
Maternal sleep disturbance is common during pregnancy and postpartum periods. This study evaluated the feasibility and efficacy of a scalable cognitive behavioural therapy (CBT) sleep intervention tailored for these periods.

Methods
This is a two-arm, parallel-group, single-blind, superiority randomised controlled trial. Nulliparous women without major medical/psychiatric conditions were randomised 1:1 to CBT or active control of equal frequency/duration. All participants received a 1-hr telephone session and automated multimedia emails from the 3rd trimester until 6 months postpartum. Outcomes were assessed with validated instruments at gestation weeks 30 (baseline) and 35 (pregnancy endpoint), and postpartum months 1.5, 3, 6 (postpartum endpoint), 12, and 24.

Results
163 eligible participants (age M +/- SD = 33.35 +/- 3.42) were randomised. The CBT intervention was well accepted, with no reported adverse effect. Intention-to-treat analyses showed that compared to active control, receiving CBT was associated with lower insomnia severity and sleep disturbance (two primary outcomes), and lower sleep-related impairment at the pregnancy endpoint (p-values ≤ .001), as well as at 24 months postpartum (p ranges .012-.052). Group differences across the first postpartum year were nonsignificant. Women with elevated insomnia symptoms at baseline benefitted substantially more from CBT (vs control), including having significantly lower insomnia symptoms throughout the first postpartum year. Group differences in symptoms of depression or anxiety were nonsignificant.

Conclusion
A scalable CBT sleep intervention is efficacious in buffering against sleep disturbance during pregnancy, with long-term benefits to maternal sleep, especially for women with sleep complaints during pregnancy. The intervention holds promise for implementation into routine perinatal care.

Support (if any)
Data collection was supported by Rob Pierce Grant-in-Aid and Helen Bearpark Scholarship from Australasian Sleep Association, Strategic Grant Scheme from Monash University, and the Royal Women’s Hospital Foundation. Intervention materials were adapted from those developed via a National Institute of Health R01 grant (NR013662). Bei (APP1140299) and Wiley (APP1178487) are supported by National Health and Medical Research Council Fellowships, and Pinnington, Quin, Shen by Australian Postgraduate Awards by Department of Education and Training. The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
358 Daridorexant Improves Sleep in Patients with Mild/Moderate Obstructive Sleep Apnea
Authors: Boof Marie-Laure , Fietze Ingo , Lederer Katharina , Guern Anne-Sophie , Lemoine Vincent , Ufer Mike , Dingemanse Jasper 
Published: May 2021

Abstract

Introduction
Daridorexant is a dual orexin receptor antagonist developed for the treatment of insomnia. The effect of the highest phase-3 dose of 50 mg daridorexant on nighttime respiratory function was evaluated in patients with mild/moderate obstructive sleep apnea (OSA). This study showed that repeated doses of daridorexant had no clinically meaningful effect on the apnea-hypopnea index (AHI) or on peripheral oxygen saturation. In the same study, the effect on objective sleep parameters was also explored by polysomnography (PSG).

Methods
In this randomized, double-blind, placebo-controlled, two-period, crossover study, daridorexant or placebo was administered in each period once daily for 5 consecutive nights to 28 patients. Treatment difference (daridorexant – placebo) for total sleep time (TST), latency to persistent sleep (LPS), and wake after sleep onset (WASO) was analyzed for Night 5 using linear mixed-effects modeling. In addition, sleep was further explored based on sleep duration during each hour of PSG recording, duration of the different sleep phases (rapid eye movement [REM], non-REM [including N1 to N3 sleep stages]), as well as number and mean/longest duration of awakenings.

Results
Of 28 patients enrolled, 25 completed the study and were included in the analysis (n=15/10 with mild/moderate OSA; mean [standard deviation] AHI: 16.3 [8.2] events/h). One patient had mild insomnia symptoms at baseline. Compared to placebo, daridorexant prolonged mean TST by 38.8 min (90% confidence interval: 19.7–57.9), shortened mean LPS by 17.2 min (-35.5–1.02), and reduced mean WASO by 31.0 min (-47.3 to 14.7). Sleep architecture was maintained as no treatment differences in the duration of the evaluated sleep stages were observed when normalized to TST. Sleep duration was prolonged in the second part of the night. mean and longest duration of awakenings were decreased by a mean (90% CI) of 2.0 min (-3.1 to 0.9) and 16.3 min (-24.1 to -8.6), respectively, without treatment difference for the total number of awakenings.

Conclusion
Daridorexant improved objective sleep parameters in patients with mild to moderate OSA without modifying sleep architecture.

Support (if any)
Funded by Idorsia Pharmaceuticals Ltd.
360 Efficacy of CBT-I and its Components on Health-Related Quality of Life Outcomes in Older Adults
Authors: Showen Kelly , O’Hora Kathleen , Hernandez Beatriz , Lazzeroni Laura , Zeitzer Jamie , Friedman Leah , Posner Donn , Kushida Clete , Yesavage Jerome , Goldstein-Piekarski Andrea 
Published: May 2021

Abstract

Introduction
Insomnia affects 30–48% of older adults and impairs health-related quality of life (HRQoL). Numerous studies report Cognitive Behavioral Therapy (CBT-I) as an effective non-pharmacological treatment for insomnia symptoms, with few examining the impact of CBT-I on mental and physical aspects of HRQoL. While limited research suggests that CBT-I leads to improvements in HRQoL, the impact of the cognitive versus behavioral components of CBT-I on HRQoL is unknown.

Methods
128 older adults with insomnia (mean age=69, 66% female, 19% minority) were randomized to receive cognitive therapy (CT), behavior therapy (BT), or CBT-I. The Short Form (36) Health Survey (SF-36) was collected at baseline, post-treatment and six-month follow-up. Split-plot linear mixed models with age and sex as covariates to assess within and between subject changes were used to test intervention, time, and interaction effects on the mental health and physical well-being domains of HRQoL. Significance for all effects was defined as p &lt; 0.05. The effect size (d) was calculated by dividing the difference between means by the root-mean-squared error of the mixed effects model.

Results
The mental health-related QoL improved over time independent of treatment (Main effect of time: F(2, 202) = 6.51, p &lt; 0.002). The interaction failed to reach significance (Interaction: F(4, 202) = 1.19, p = .31). Simple effects revealed significant improvements among CBT-I participants at six months (p = .02, d = .53) and CT participants at post-treatment (p = .00, d = .79) and six months (p = .03, d = .66), but not among BT participants for either time point (p = .32, d = .24; p = .16, d = .35). Treatment did not improve physical health-related QoL over time (F(2, 202) = 1.01, p = .37) nor was there a significant interaction (F(4, 202) = .46, p = .76).

Conclusion
These findings suggest that CBT-I, particularly the CT component, may be effective in improving mental health-related QoL outcomes for older adults with insomnia. In contrast, neither CBT-I nor its component treatments were effective in improving physical health-related QoL.

Support (if any)
NIMHR01MH101468-01; Mental Illness Research, Education, and Clinical Center (MIRECC) at the VAPAHCS
362 Efficacy of Sleep hygiene advices for individuals with poor sleep quality
Authors: Johnson Saumy , Al Abdulkareem Dr Sami 
Published: May 2021

Abstract

Introduction
Though sleep hygiene practice is a promising approach to individuals with poor sleep quality, less research has been done in different ethnic population regarding the effect of sleep hygiene in individuals with poor sleep quality. Aim: To investigate the efficacy of sleep hygiene among individuals with poor sleep quality

Methods
Methodology: This was a prospective study of 250 participants from different ethnic populations using the Pittsburgh Sleep Quality Index (PSQI). Sleep hygiene advices were given online to the individuals with poor sleep quality (PSQI &gt; 5). Post- test of PSQI score was done after 8 weeks following the Sleep hygiene practices. Survey was done online through google forms and the score was calculated and the level pf sleep quality was sent to the participants (good or poor). A cut of value of PSQI 5 was taken in to consideration. .Questionnaire was sent to participants through snowball sampling.

Results
Results There were 250 participants in this study and the sleep quality index was found to be significantly different (p&lt;0.001) between pre- and post-intervention (Sleep hygiene advice). Age was 30.21±10.70 (mean ± SD) years and there were 157 (63%) females and 93 (37%) males. There were participants from 16 countries, majority responses from India, Saudi and Philippines. PSQI was 8.58 ± 2.49 before the sleep hygiene advice and 5.74± 1.86 post sleep hygiene practice. There was a significant improvement in the sleep quality. Significant correlation was seen between global PSQI score and the 7 components of the PSQI scoring.

Conclusion: Conclusion
Sleep hygiene can help in improving the sleep quality of individuals with poor sleep quality
Support (if any):
368 Durability of Tx Response to Zolpidem using a Partial Reinforcement Regimen: Does this strategy require contingent reinforcement?
Authors: Perlis Michael , Morales Knashawn , Vargas Ivan , Muench Alexandria , Seewald Mark , D’Antonio Breanna , Grandner Michael 
Published: May 2021

Abstract

Introduction
In 2015, partial reinforcement (PR) was assessed as an alternative approach to maintenance therapy with zolpidem. The method being: once a treatment response is obtained over the course of 1-month’s Tx with QHS dosing (Phase-1), Tx response can maintained over time with a PR regimen (Phase-2 [nightly pill/capsule use with 50% of capsules having medication and 50% having only inert filler]). In that study, it was assumed that Phase1 QHS dosing was required 1) to maximize treatment responding and 2) for the conditioning of pharmacologic responses to the medication vehicle (capsule). In the present study, these assumptions were tested by including both QHS and PR arms into Phase-1.

Methods
In Phase-1 (1 month), subjects were randomized to the QHS or PRS conditions (2QHS:1PRS). In Phase-2 (3 months), the PRS group continued forward without a change in the treatment regimen (variable dose [VD-VD]) and the QHS group was re-randomized to either continued QHS Tx (full dose [FD-FD]) or to PRS Tx [FD-VD]). Both study phases were evaluated for treatment responses rates and for average change in TWT (SL+WASO+EMA).

Results
55 subjects (age 61.2+/-8.1, 64% female, & 73% white) were enrolled into Phase-1; 39 were randomized to the QHS condition and 16 to the PRS condition. In Phase-1, 77% (QHS) and 50% (PRS) exhibited treatment responses (p=0.09) where the average change in TWT was similar by group (QHS was -43min [CI -76,-9] and PRS was -76min [CI -138,-14];p=0.35). In Phase-2, 73% (FD-FD), 57% (FD-VD), and 88% (VD-VD) exhibited continued treatment responses (p=0.22) where the average improvement of TWT continued with FD-FD and remained stable for FD-VD and VD-VD (p&lt;0.01).

Conclusion
These data, while preliminary, suggest that QHS (vs. PRS) dosing produces more treatment responders and similar initial effects on sleep continuity during Phase-1, comparable maintenance of treatment response over time, and continued improvement on sleep continuity during Phase-2. These results suggest that partial reinforcement can maintain effects but cannot allow for the additional clinical gains afforded by continuous treatment. Given this, it may be the case that the partial reinforcement technique could be improved upon by extending phase from 1 to 2–4 months.
Support (if any):