bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grado de incumplimiento terapéutico en función del nivel de alfabetización en salud en pacientes en hemodiálisis
Authors: Pelayo Alonso Raquel , Martínez Álvarez Patricia , Cagigas Villoslada Mª José , Cobo Sánchez José Luis , Palacio Cornejo Clara Mª 
Published: June 2021

Introducción: El paciente en hemodiálisis está sometido a un régimen terapéutico cuya adherencia contribuye a disminuir la aparición de complicaciones asociadas mejorando la morbimortalidad. El incumplimiento terapéutico es un problema prevalente en la práctica clínica. Bajos niveles de alfabetización en salud se relacionan con falta de autocuidados, errores en la toma de medicaciones y dificultad para entender instrucciones, lo que trae consigo una mayor tasa de incumplimiento terapéutico. Objetivo: Conocer el grado de incumplimiento terapéutico en función del grado de alfabetización en salud de los pacientes sometidos a hemodiálisis. Material y Método: Estudio prospectivo en 35 pacientes en programa de hemodiálisis. La alfabetización en salud se valoró con el cuestionario Health Literacy Survey European Union y el grado de incumplimiento terapéutico mediante la ganancia de peso interdialítica e indicadores analíticos, según recomendaciones de guías clínicas. Resultados: Los pacientes con nivel de alfabetización adecuada (≥34 puntos) presentaron menor incumplimiento terapéutico que pacientes con alfabetización inadecuada en relación a ganancia de peso interdialítica (78%vs 70%), potasio (67%vs56%), albúmina (83%vs72%) pero mayor IT con el fósforo (83,33%vs51,44%) – p<0,05 en todos los casos-. Conclusiones: Los pacientes con mayor nivel de alfabetización en salud tienen un menor grado de incumplimiento terapéutico, a excepción del fósforo, que es el parámetro con peor tasa de adherencia.
Reversible enzyme-catalysed reactions: the quasi steady state as a a quasi-equilibrium, and a correction to Haldane's kinetic constants and to secondary relationships involving kinetic constants.
Authors: Barnsley Eric A 
Published: June 2021

For reversible enzyme-catalysed reactions obeying Henri-Michaelis-Menten kinetics, theoretical solution of the rate equations for the enzyme-substrate intermediate are generally incorrect when the quasi-steady state approximation, equating the rate of change of the concentration of the enzyme-substrate intermediate to zero, is used. For the simplest kinetic model used by Haldane, such a procedure does not reveal that in one direction, that starting with the reactant having the lower binding constant, the quasi-steady state is one of quasi-equilibrium, and Haldane’s structure of the Km written in terms of rate constants is incorrect. This is probably also true of more complex mechanisms in which the structure of kcat may also be in error. Modern methods of numerical integration for the solution of rate equations, if applied to reversible reactions to obtain rate constants from measured catalytic constants, will require the correct expressions for kcat and Km. Furthermore, the (now called) Haldane relationship, relating the kinetic constants kcat and Km for the forward and reverse reactions to the equilibrium constant of a reaction, is now seen to be generally incorrect, and in addition another exception for a the theoretical validation of kcat /Km as a specificity constant arises.
NGC 6845 Revisited: Stellar Kinematics on the Early Type Member Galaxies
Authors: Gimeno German , Díaz Ruben J. , Dottori Horacio , Rodrigues Irapuan , Mast Damian 
Published: June 2021

Abstract
We observed the compact group of galaxies NGC 6845 with GMOS-S imaging and long-slit spectroscopy. The group itself is comprised of two spiral galaxies and two S0 galaxies, and shows signs of gravitational interaction among them. While the spiral galaxies have been already well studied, the two S0 galaxies have received little attention. We investigate the morphology and stellar kinematics of the two S0 galaxies in detail in order to derive the value for their mass and subsequently incorporate them into the mass model for the group. It was found that the internal kinematics of the largest S0 (NGC 6845 C) is mostly regular, while the smallest S0 (NGC 6845 D) shows some hint of interaction, most likely with NGC 6845 C and NGC 6845 A. The new determination of the dynamical mass of the group implies that the group mass has to be 10 times the combined mass of the individual members according to their internal kinematics. The results point to an early stage of the group interaction and also to the possibility that it has still not reached virial equilibrium. From the galaxy evolution viewpoint, this group represents an example of the case of the transformation of Spirals into S0 galaxies in dense environments.
Foreshock as a Source Region of Electron-scale Magnetic Holes in the Solar Wind at 1 au
Authors: Wang G. Q. , Volwerk M. , Xiao S. D. , Wu M. Y. , Chen Y. Q. , Zhang T. L. 
Published: June 2021

Abstract
Electron-scale magnetic holes (ESMHs) can dissipate energy and transport electrons in astrophysical plasmas. They are often observed in the solar wind at 1 au, but whether they are locally generated remains unclear. Here we investigate the ESMHs in the solar wind at 1 au based on observations of the Magnetospheric Multiscale (MMS) and Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon’s Interaction with the Sun (ARTEMIS) P1 spacecraft. There are 47 and 18 ESMH events observed by MMS1 and ARTEMIS P1, respectively, where an isolated ESMH or a train of ESMHs is regarded as an ESMH event. Our findings are as follows: (1) the occurrence rate of the ESMH events observed by MMS1 is much larger than that by ARTEMIS P1, which is located in the upstream solar wind; and (2) the proportion of the train of ESMHs in the ESMH events observed by each spacecraft is much higher in the ion foreshock than that in the undisturbed solar wind. These observations suggest that the terrestrial foreshock is an important source region of the ESMHs at 1 au, while some ESMHs come from the upstream undisturbed solar wind. The generation of these ESMHs can be explained by the electron vortex magnetic hole. Finding out the origin of the electron vortex may help to shed light on the whole chain of their generation and evolution in the foreshock.
Accretion-Induced Collapse of Neutron Stars in the Disks of Active Galactic Nuclei
Authors: Perna Rosalba , Tagawa Hiromichi , Haiman Zoltán , Bartos Imre 
Published: June 2021

Abstract
The disks of active galactic nuclei (AGNs) have emerged as a rich environment for the evolution of stars and their compact remnants. The very dense medium favors rapid accretion, while torques and migration traps enhance binary formation and mergers. Both long and short gamma-ray bursts are hence expected. We show that AGN disks constitute an ideal environment for another interesting phenomenon: the accretion-induced collapse (AIC) of neutron stars (NSs) to black holes (BHs). Rapid accretion in the dense disks can cause NSs to grow to the point of exceeding the maximum mass allowed by their equation of state. General relativistic magnetohydrodynamical simulations have shown that electromagnetic signatures are expected if the NS is surrounded by a minidisk prior to collapse, which then rapidly accretes onto the BH, and/or if the NS is highly magnetized, from reconnection of the magnetosphere during collapse. Here we compute the rates of AICs and their locations within the disks for both isolated NSs and for (initially stable) NSs formed from NS-NS mergers. We find that the global AIC rates are ∼0.07–20 Gpc−3 yr−1, and we discuss their observable prospects and signatures as they emerge from the dense disk environments.
Element Abundance Analysis of the Metal-rich Stellar Halo and High-velocity Thick Disk in the Galaxy
Authors: Zhu Haifan , Du Cuihua , Yan Yepeng , Shi Jianrong , Ma Jun , Newberg Heidi Jo 
Published: June 2021

Abstract
Based on the second Gaia data release (DR2) and APOGEE (DR16) spectroscopic surveys, we define two kinds of star samples: high-velocity thick disk (HVTD) with v

ϕ
> 90 km s−1 and metal-rich stellar halo (MRSH) with v

ϕ
< 90 km s−1. Due to high-resolution spectra data from APOGEE (DR16), we can accurately analyze the element abundance distribution of HVTD and MRSH. These element abundances constitute a multidimensional data space, and we introduce an algorithm method for processing multidimensional data to give the result of dimensionality reduction clustering. According to chemical property analysis, we derive that some HVTD stars could originate from the thin disk and some MRSH stars could originate from dwarf galaxies, but those stars that have similar chemical abundance characteristics in both samples may form in situ.
Comparison of Outcomes Between Combined Sparing Laser Photocoagulation and Intravitreal Bevacizumab Treatment Versus Conventional Laser Photocoagulation in Aggressive Posterior Retinopathy of Prematurity
Authors: Ittarat Mantapond 
Published: June 2021

Purpose:
To report the clinical outcomes of combined sparing laser photocoagulation and intravitreal bevacizumab treatment compared to conventional laser photocoagulation for the treatment of aggressive posterior retinopathy of prematurity (APROP).

Methods:
A medical chart review was performed on all consecutive eyes with APROP that were treated with conventional laser photocoagulation or laser photocoagulation and intravitreal bevacizumab (IVB) injection between July 2019 and August 2020. The data were recorded for time to reversal of plus disease, time to total regression of retinopathy of prematurity (ROP) after intervention, total laser spots and area, proportion of eyes with satisfactory anatomical outcomes, and adverse events. Outcomes of the two groups were compared.

Results:

Sixteen eyes of 8 infants with APROP were included in the analysis. Eight eyes of 4 infants received combined sparing laser photocoagulation and IVB treatment, and 8 eyes of 4 infants received conventional laser photocoagulation. All 8 eyes in the combined treatment group and 6 of 8 eyes in the conventional treatment group showed regression of ROP with a satisfactory anatomical outcome. The average time to total regression of ROP was 34 days in the combined treatment group and 56 days in the conventional treatment group (
P
= .005). The number of laser spots was significantly lower in the combined treatment group (
P
= .03).

Conclusions:
Combined sparing laser photocoagulation and IVB treatment for eyes with APROP achieved ROP regression twice as fast, had fewer laser spots, and had a satisfactory anatomical outcome in comparison to conventional laser photocoagulation.

[
J Pediatr Ophthalmol Strabismus
. 2021;58(5):292–297.]
TARM-1 Is Critical for Macrophage Activation and Th1 Response in Mycobacterium tuberculosis Infection
Authors: Li Xingyu , Wang Manni , Ming Siqi , Liang Zibin , Zhan Xiaoxia , Cao Can , Liang Sipin , Liu Qiaojuan , Shang Yuqi , Lao Juanfeng , Zhang Shunxian , Kuang Liangjian , Geng Lanlan , Wu Zhilong , Wu Minhao , Gong Sitang , Wu Yongjian 
Published: June 2021

Abstract
T cell–interacting activating receptor on myeloid cells 1 (TARM-1) is a novel leukocyte receptor expressed in neutrophils and macrophages. It plays an important role in proinflammatory response in acute bacterial infection, but its immunomodulatory effects on chronic Mycobacterium tuberculosis infections remain unclear. TARM-1 expression was significantly upregulated on CD14high monocytes from patients with active pulmonary tuberculosis (TB) as compared that on cells from patients with latent TB or from healthy control subjects. Small interfering RNA knockdown of TARM-1 reduced expression levels of proinflammatory cytokines IL-12, IL-18, IL-1β, and IL-8 in M. tuberculosis–infected macrophages, as well as that of HLA-DR and costimulatory molecules CD83, CD86, and CD40. Moreover, TARM-1 enhanced phagocytosis and intracellular killing of M. tuberculosis through upregulating reactive oxygen species. In an in vitro monocyte and T cell coculture system, blockade of TARM-1 activity by TARM-1 blocking peptide suppressed CD4+ T cell activation and proliferation. Finally, administration of TARM-1 blocking peptide in a mouse model of M. tuberculosis infection increased bacterial load and lung pathology, which was associated with decreased macrophage activation and IFN-γ production by T cell. Taken together, these results, to our knowledge, demonstrate a novel immune protective role of TARM-1 in M. tuberculosis infection and provide a potential therapeutic target for TB disease.
Aberrant acquisition of T-cell associated markers in plasma cell neoplasms: An aggressive disease with extramedullary involvement and very short survival
Authors: Soliman Dina Sameh , Elsabah Hesham , Ganwo Ibrahim , Amer Aliaa , Taha Ruba Y , Szabados Lajos , Sharaf Eldean Mouhammad , Al-Sabbagh Ahmad , Ibrahim Feryal 
Published: June 2021

Background:
Plasma cell neoplasms can show aberrant expression of a different lineage-related antigens, however, co-expression of T-cell associated markers on malignant plasma cells is extremely rare.
Material and methods: This is a report of clinicopathologic characteristics of three myeloma patients with emergent plasmablastic morphology and aberrant acquisition of T‐cell associated markers. An extensive literature search for similar cases was conducted and the relevant pathologic, clinical and prognostic characteristics were summarized.
Results: A total of 22 cases of plasma cell neoplasm, showed aberrant co-expression of T-cell markers. We found an evident association between aberrant expression of T-cell markers on malignant plasma cells and extramedullary involvement, aggressive morphologic features, high proliferative index ki67 >90%, aggressive clinical course, adverse outcome with short survival.
Conclusion:
Due to rarity of this aberrant phenotype and scarcity of the published data, the precise causative mechanism and its clinical implications have not yet been elucidated.
CROCIN PROMOTES APOPTOSIS IN HUMAN EBV-TRANSFORMED B-LYMPHOCYTE VIA INTRINSIC PATHWAY
Authors: Sotoodeh Jahromi Abdolreza , Kargar Mohammad , Kafilzadeh Farshid , Jamalidoust Marzieh , Moradzadeh Maliheh 
Published: June 2021

Background: As a major carotenoid in saffron, crocin demonstrates potent anti-cancer impacts. However, its anti-lymphoma effects remain vague, especially in the human EBV-associated B-cell lymphoproliferative disorders. This study examined crocin's apoptogenic potential and its underlying mechanism in CO 88BV59-1 cell line vs. normal human peripheral blood B cells.
Methods: CO 88BV59-1 cells were treated with crocin alone or in combination with vincristine for up to 72 h. The cell viability was examined using a resazurin assay. Flow cytometry using annexin V and propidium iodide labeling was performed to detect apoptotic cells. Also, the expression levels of genes and proteins involved in apoptosis (CASP3, CASP8, CASP9, P53, Bax, and Bcl-2) were respectively determined via real-time PCR and Western blot analysis.
Results: Crocin concentration-dependently reduced cell viability in CO 88BV59-1 cells with no significant toxicity toward normal B cells. Similar to vincristine, crocin significantly increased apoptosis in these cells during 72 h of incubation. Furthermore, the combination of crocin (80 μM) and vincristine (1 μM) enhanced apoptosis in CO 88BV59-1 cells. Therefore, this synergistic effect was detected in human EBV-transformed B-lymphocyte. CASP3, CASP9, P53, and Bax/Bcl-2 ratio expressions were significantly raised in CO 88BV59-1 cells, whereas CASP8 was unaltered. It was proposed that crocin promoted apoptosis in CO 88BV59-1 cells in a time- and concentration-dependent manner via the induction of the intrinsic pathway.
Conclusion: The results suggest that crocin may serve as a good alternative/coadjuvant to vincristine in EBV-associated B-cell lymphoproliferative disorders.
Keywords: Crocin, CO 88BV59-1 cells, EBV-associated B-cell lymphoproliferative disorders, apoptosis
The Impact of the 4th Industrial Revolution on the High-Tech Industry
Authors: Trento Sandro , Bannò Mariasole , D’Allura Giorgia 
Published: June 2021

The challenges of the 4th Industrial Revolution (I40) entail new business models to improve customer value creation. So far, academic investigation into I40 has been extensively focused on large enterprises, and only marginally on SMEs. The present paper aims to answer to the following four research questions: How do manufacturing SMEs perceive the I40 phenomenon? How do manufacturing SMEs innovate their business models because of I40? How do manufacturing SMEs behave with their suppliers because of I40? How do manufacturing SMEs behave with their customers because of I40?
“Parece que é normal conviver com uma pessoa que tem HIV”
Authors: Souza Laís Machado de , Souza Marcos Lopes de 
Published: June 2021

O objetivo desse estudo foi analisar os discursos sobre as relações afetivo-sexuais entre sorodiscordantes construídos por professoras durante processo formativo envolvendo as questões de sexualidade e saúde. Trata-se de uma pesquisa ancorada nos estudos pós-críticos e pós-estruturalistas em que utilizamos artefatos culturais como mediadores dos momentos formativos realizados com professoras da área de Ciências Naturais, que lecionam a disciplina Educação para Sexualidade em uma escola na cidade de Jequié-BA. Há uma linha tênue entre ignorância, medo e discriminação nos discursos das professoras referentes às relações entre sorodiscordantes, mas também vislumbramos novas perspectivas de problematizações das práticas e discursos que (re)produzem uma cultura estigmatizante daqueles(as) que vivem com HIV/aids e a vivência de seus afetos e prazeres.
GÖZÜBÜYÜKZÂDE İBRÂHİM EFENDİ VE MECMUATÜ’R-RESÂİL’İNDEKİ ARAP DİLİNE DAİR RİSALELERİNİN İNCELENMESİ
Authors: UÇKAN Şemsettin , ABAK Bahattin 
Published: June 2021

Gözübüyükzâde İbrâhim Efendi 18-19. Yüzyılda Kayseri’de yaşamış Osmanlı âlimlerindendir. İslamî ilimleri çeşitli medrese ve âlimlerden tahsil etmiş, ömrünü talebe yetiştirerek geçirmiştir. İleri görüşlü ve ince meseleleri çözmedeki mahareti sebebiyle Gözübüyükzâde lakabı verilmiştir. Tedrîsin yanı sıra birçok alanda eser telif etmiş olan Gözübüyükzâde’nin eserleri başta Süleymaniye Kütüphanesi olmak üzere birçok kütüphanede yazma ve matbu olarak bulunmaktadır. Âlimin birçok risalesi Mecmu'atü’r-resâil adlı mecmuada toplanmış olup neşredilmiştir (İstanbul 1259).
Mecmua içerisinde Risâletün fî kelimeti emmâ ba‘dü, Risaletün fî sukût hemzeti ibn beyne ‘alemeyn, Risâle fî hakki’l-istisnâ gibi Arap diline dair bir çok risale mevcuttur. Çalışmada Mecmu'atü’r-resâil’teki Arap diline dair eserler ele alınıp, risalelerin yazılış amaçları, muhtevaları ve risalelerde kullanılan kaynaklar hakkında bilgi verilecektir. Bu vesile ile kültürümüzün alimlerinden birinin hayatı, eserleri ve Arap diline katkıları ortaya çıkarılacaktır.
Penerapan Tata Kelola Teknologi Informasi dan Pengukuran Maturity Level Menggunakan Domain MEA (Monitor, Evaluate Dan Assess) Dengan Framework COBIT (Studi Kasus: Sistem Informasi Akademik AIKOM
Authors: Sabtu Junaidi 
Published: June 2021

The Academy of Computer Science (AIKOM) Ternate has implemented information technology in the Academic Information System (SIAK) section, which is an important part of connecting management with all stakeholders. Formulation of the problems raised in this study includes how to classify problems into statements that are in accordance with COBIT 5 framework and how to determine and measure the maturity level of IT governance at AIKOM Ternate by using the MEA (Monitor, Evaluate and Assess) domain. The researcher used a questionnaire instrument to measure the maturity level of IT governance at AIKOM Ternate. The sample used was 13 people including the leadership and several staff. Based on the calculation of the maturity level of IT governance, a value for MEA01 (Performance and Conformance) is obtained at 3.2, MEA02 (The System of Internal Control) of 3.3, and MEA03 (Compliance With External Requirements) of 3.3, which means that each subdomain is at level 3, which means Established Process, so that the average MEA maturity level is 3.3, which is in the Established Process status. The results of the recommendations of this study are for MEA01 subdomains need to establish guidelines and SOPs for the implementation of monitoring and evaluation of SIAK, there needs to be monitoring from the leadership of the duties of each stakeholder and set the standard reporting process from data collection, time and feedback from report results. The recommendation for the MEA02 subdomain is that AIKOM Ternate must develop a mechanism for controlling SIAK, develop SIAK quality assurance standards and carry out periodic evaluations of quality assurance. And recommendations for the MEA03 subdomain carry out periodic reviews and make guidelines and SOPs related to SIAK changes based on external changes.
EVALUATION OF BLS WORKSHOPS, AN AUDIT OF THE JOURNEY SO FAR
Authors: Hassan Sidra , Memon Amjad Siraj , Jamalvi Waseem , Ahmed Qasim 
Published: June 2021

Objective: Professional training workshops are routinely conducted by Professional Development Center (PDC) of DUHS to provide students golden opportunities in hands on practice on simulators and also has been working as training center of AHA since 2010 for the BLS, ACLS and PALS provider and instructor courses while has been conducting BLS workshops from Nov, 2005. The objective of this study was to assess the perceptions of attending audience by post course evaluation form in BLS program.
Methodology: This was a retrospective survey study. Data of BLS workshops from 2017 to 2018 was collected from PDC. Two thousand and fifty six healthcare students were enrolled in BLS course from Jan 2017 till Dec 2018. The calculated sample size was about 324 at 95% confidence level. Thus the final sample size was about 350. A post workshop evaluation questionnaire was used as a tool for data collection and it was analyzed on SPSS.
Results: PDC has conducted 714 BLS provider courses since 2005 in which 8529 participants are trained till now. The results of the evaluation show that this workshop received higher score on all assessed sections i.e. more than 90% candidates marked agree & strongly agree. A clear majority of participants (97.8%) agreed that, their queries and questions were satisfactorily responded The structure and content of the workshop organized intensify participants’ skills and knowledge regarding BLS.
Conclusion: Overall, Participants characterized the workshop as very useful and were very satisfied with the workshop facilitators and the topics discussed.