bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recombinant cystatin-like protein-based competition ELISA for Trichinella spiralis antibody test in multihost sera
Authors: Liu Yan , Xu Ning , Li Yansong , Tang Bin , Yang Hualin , Gao Weihua , Liu Mingyuan , Liu Xiaolei , Zhou Yu 
Published: August 2021

ObjectivesTrichinella spiralisis a zoonotic parasite with a complex parasitic life cycle and exposed to animals or humans by infectious meat. To control transmissions ofT.spiralisthrough the food chain to humans, sensitive and selective multihost sera-diagnosis is urgent needed for monitoringT.spiralisexposure.MethodsA competition enzyme-linked immunosorbent assay (cELISA) forT.spiralisinfection diagnosis in multihost sera was developed based on recombinant cystatin-like protein (rCLP-cELISA) as well as monoclonal antibodies. The sensitivity and accuracy of the rCLP-cELISA were quantified using swine (n = 1316), mice (n = 189) and human (n = 157) serum samples.T.spiralis-antibody targeting test ability of the rCLP-cELISA in swine (n = 22) and human (n = 36), instead of other parasites or viruses antibodies, was evaluated.ResultsThe rCLP-cELISA showed high agreement with commercial ELISA kits in field swine sera assessed by Cohen’s kappa value (κ = 0.7963). And it showed 100% specificity in human trichinellosis detection with sensitivity of 96.49%, no cross-reaction with other parasite or virus infections, and high positive detection rate of 87.5% in low-dose infected swine. Besides, the rCLP-cELISA exhibited potential in the detection ofT.spiralis,T.nelsoniandTrichinellaT8 infections.ConclusionsThe rCLP-cELISA can be used forT.spiralis-associated antibody test in multihost sera.
Baseline homeostasis model assessment of insulin resistance associated with fibrosis progression in patients with nonalcoholic fatty liver disease without diabetes: A cohort study
Authors: Koo Dae-Jeong , Lee Mi Yeon , Jung Inha , Moon Sun Joon , Kwon Hyemi , Park Se Eun , Rhee Eun-Jung , Lee Won-Young 
Published: August 2021

Background and aims
Fibrosis progression is the most important prognostic factor, and insulin resistance is one of the main mechanisms associated with fibrosis progression in patients with nonalcoholic fatty liver disease (NAFLD). We evaluate the association between baseline insulin resistance and future fibrosis progression in patients with NAFLD without diabetes.

Approach and results
This retrospective longitudinal study with 8-year follow-up period included 32,606 (men, 83%) participants aged >20 years (average age, 38.0 years) without diabetes at baseline who completed at least two comprehensive health checkups from January 1, 2010 to December 31, 2018. NAFLD was diagnosed based on ultrasonography. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to evaluate baseline insulin resistance. Fibrosis progression was assessed using the aspartate aminotransferase to platelet ratio index (APRI). The advanced liver fibrosis with an APRI value above the intermediate fibrosis probability (≥0.5) developed in a total of 2,897 participants during 136,108 person-years. 114 participants progressed to a high fibrosis probability stage (APRI >1.5) during 141,064 person-years. Using the lowest baseline HOMA-IR quartile group (Q1) as a reference, the multivariate-adjusted hazard ratio (HR) for development of advanced liver fibrosis (APRI ≥0.5) in the highest baseline HOMA-IR quartile group (Q4) was 1.95 (95% confidence interval [CI] 1.74–2.19; Model 4). And the HR for development of advanced liver fibrosis with high fibrosis probability was 1.95 (95% CI 1.10–3.46; Model 4). The positive association was maintained throughout the entire follow-up period. The baseline HOMA-IR model was superior to the baseline body mass index (BMI) model in predicting the progression of fibrosis probability.

Conclusions
In this longitudinal study, we found that the degree of baseline insulin resistance, assessed by HOMA-IR values, was positively associated with future fibrosis progression in patients with NAFLD without diabetes.
Association of mental health help-seeking with mental health-related knowledge and stigma in Japan Rugby Top League players
Authors: Ojio Yasutaka , Matsunaga Asami , Yamaguchi Sosei , Hatakeyama Kensuke , Kawamura Shin , Yoshitani Goro , Horiguchi Masanori , Nakajima Shun , Kanie Ayako , Horikoshi Masaru , Fujii Chiyo 
Published: August 2021

BackgroundGlobally increasing clinical and research interests are driving a movement to promote understanding and practice of mental health in elite athletes. However, few studies have yet addressed this issue. This study aims to describe the association of the intention to seek help with mental health knowledge and stigma and the severity of depressive symptoms in Japan Rugby Top League players.MethodsAs a target population, we studied 233 Japan Rugby Top League male players (25–29 years = 123 [52.8%]), who were born in Japan, using a cross-sectional design. Surveys were conducted using anonymous, web-based self-administered questionnaires. Structural equation modelling was performed to evaluate the hypothesis of an interrelationship between mental health knowledge, stigma, and severity of depressive symptoms as factors influencing the intention to seek help.ResultsPlayers with more severe depressive symptoms were more reluctant to seek help from others (β = - 0.20, p = 0.03). Players with greater knowledge about mental health tended to have less stigma toward others with mental health problems (β = 0.13, p = 0.049), but tended not to seek help with their own mental health problems.ConclusionsRugby players in need of mental health support, even with greater knowledge, tend not to seek help from others, while having less stigma toward people with mental health problems. Rugby players might require approaches other than a knowledge-based educational approach to encourage them to seek help.
What is the likely impact on surgical site infections in Australian hospitals if smoking rates are reduced? A cost analysis
Authors: McCaffrey Nikki , Scollo Michelle , Dean Emma , White Sarah L. 
Published: August 2021

IntroductionAssisting smokers to quit before surgery reduces surgical site infection (SSI) risk. The short-term economic benefits of reducing SSIs by embedding tobacco dependence treatment in Australian hospitals are unknown. Estimated annual number of SSIs prevented, and hospital bed-days (HBD) and costs saved from reducing smoking before surgery are calculated.MethodsThe most recent number of surgical procedures and SSI rates for Australia were sourced. The number of smokers and non-smokers having a SSI were calculated using the UK Royal College of Physicians reported adjusted odds ratio (1.79), and the proportion of SSIs attributable to smoking calculated. The potential impact fraction was used to estimate reductions in SSIs and associated HBDs and costs from reducing the smoking rates among surgical patients from 23.9% to 10% or 5% targets. Uncertainty around the final estimates was calculated using probabilistic sensitivity analysis.ResultsIn 2016–17, approximately 40,593 (95% UI 32,543, 50,239) people having a surgical procedure in Australia experienced a SSI leading to 101,888 extra days (95% UI 49,988, 200,822) in hospital. If the smoking rate among surgical patients was reduced to 10%, 3,580 (95% UI 2,312, 5,178) SSIs would be prevented, and 8,985 (95% UI 4,094, 19,153) HBDs and $19.1M (95% UI $7.7M, $42.5M) saved in one year. If the smoking rate was reduced to 5%, 4,867 (95% UI 3,268, 6,867) SSIs would be prevented, and 12,217 (95% UI 5,614, 25,642) HBDs and $26.0M (95% UI $10.8M, $57.0M) would be saved.ConclusionsThe findings suggest achieving smoking rate targets of 10% or 5% would provide substantial short-term health and economic benefits through reductions in SSIs. Embedding tobacco dependence treatment in Australian hospitals would provide value for money by reducing costs and improving clinical quality and safety. A more comprehensive, modelled economic evaluation synthesising the best available evidence is needed to confirm findings.
The applicability of basic preventive measures of the pandemic COVID-19 and associated factors among residents in Guraghe Zone
Authors: Dessu Samuel , Tsehay Tadesse , Girum Tadele , Timerga Abebe , Solomon Mamo , Tsegaye Baye , Geremew Mulugeta , Migora Biru , Mesfin Yibeltal , Kemal Abdurezak , Alebel Fisha , Tolosa Omega , Tesfa Shegaw , Yasin Fedila 
Published: August 2021

Introduction
Internationally, countries have reacted to the COVID-19 outbreak by introducing key public health non-pharmaceutical interventions to protect vulnerable population groups. In response to COVID-19, the Government of Ethiopia has been taking a series of policy actions beyond public health initiatives alone. Therefore, this study was aimed to assess the applicability of basic preventive measures of the pandemic COVID-19 and associated factors among the residents of Guraghe Zone from 18th to 29th September, 2020.

Methods
Community based cross sectional study was conducted at Guraghe Zone from 18th to 29th September, 2020. Systematic random sampling method was applied among the predetermined 634 samples. Variables which had p-value less than 0.25 in bivariate analysis were considered as candidate for multivariable logistic regression model. P-value <0.05 was used as a cutoff point to determine statistical significance in multiple logistic regressions for the final model.

Result
In this study, 17.7% (95% CI: 14.7, 20.5) of the respondents apply the basic preventive measures towards the prevention of the pandemic COVID-19. In addition, being rural resident (AOR: 4.78,; 95%CI: 2.50, 8.90), being studied grade 1–8 (AOR: 3.70; 95%CI: 1.70, 7.90), being a farmer (AOR: 4.10; 95%CI: 1.25, 13.35), currently not married (AOR: 2.20, 95%CI: 1.24, 4.06), having family size 1-3(AOR: 6.50; 95%CI: 3.21, 3.35), have no diagnosed medical illness (AOR: 6.40; 95%CI: 3.85, 10.83) and having poor knowledge (AOR: 3.50; 95%CI: 1.60, 7.40) were factors which are statistically significant in multivariable logistic regression model.

Conclusion
Despite the application of preventive measures and vaccine delivery, the applicability of the pandemic COVID-19 preventive measures was too low, which indicate that the Zone is at risk for the infection. Rural residents, those who have lower educational level, farmers, non-marrieds, those who have lower family size, those who have diagnosed medical illnesses and those who have poor knowledge were prone to the infection with the pandemic COVID-19 due to the lower practice of applying the basic preventive measures. In addition, awareness creation should be in practice at all levels of the community especially lower educational classes and rural residents.
Nonuniform dichotomy spectrum and reducibility for nonautonomous difference equations
Authors: Chu Jifeng , Liao Fang-Fang , Siegmund Stefan , Xia Yonghui , Zhu Hailong 
Published: August 2021

Abstract
For nonautonomous linear difference equations, we introduce the notion of the so-called nonuniform dichotomy spectrum and prove a spectral theorem. As an application of the spectral theorem, we prove a reducibility result.
Measuring the Impact of Insurance on Recovery after Extreme Weather Events Using Nightlights
Authors: Owen Sally , Noy Ilan , Pástor-Paz Jacob , Fleming David 
Published: August 2021

Abstract
Climate change is predicted to make extreme weather events worse and more frequent in many places around the world. In New Zealand, the Earthquake Commission (EQC) was created to provide insurance for earthquakes. In some circumstances, however, homeowners affected by extreme weather events can also make claims to the EQC – for landslip, storm or flood events. In this paper, we explore the impact of this public natural hazard insurance on recovery from weather-related events. We do this by using a proxy for short-term economic recovery: satellite imagery of average monthly night-time radiance. Linking these night-time light data to precipitation data records, we compare areas which experienced damage from extreme rainfall episodes to those that suffered no damage even though they experienced extreme rainfall. Using data from three recent intense storms, we find that areas that experienced property damage, and were paid in a timely manner by EQC, did not fare any worse than areas that suffered no property damage but were exposed to these extreme precipitation events. This finding suggests that EQC insurance is serving its stated purpose by protecting claimants from the adverse impact of extreme weather events.
In situ photo-crosslinking hydrogel with rapid healing, antibacterial, and hemostatic activities
Authors: Qin Xiaolei , Mukerabigwi Jean Felix , Ma Mingzi , Huang Ruyi , Ma Mengdi , Huang Xueying , Cao Yu , Yu Yang 
Published: August 2021

Abstract
Uncontrollable bleeding is still the main cause of post-traumatic deaths due to the blood loss. Moreover, infectious complication of wound is also still a challenging problem for wound healing. Nevertheless, the currently available hemostasis drugs or materials cannot stanch bleeding well due to single function, slow in effectiveness, adhere to wounds easily, poor gas permeability, etc. Therefore, it is of a great significance to utilize a biomedical hemostatic material that can stop bleeding quickly, preventing from bacterial infections, and with good biocompatibility properties. Herein chitosan (CS) was modified with gallic acid (GA) and thrombin (TB) to prepare an antibacterial hemostatic composite dressing. The CS-based composite hydrogel dressing was obtained by acylation modification, ultraviolet curing crosslinking method and physical mixing. The in vitro results showed that our prepared CS-based composite hydrogel has obvious burst release and good degradation property. Moreover, the in vivo results showed that it has a strong antibacterial property that is much better than single CS, and it can stop bleeding in 1 min which can promote wound healing. Therefore, the findings of this study is expected to contribute to the future designing of biomedical hemostatic materials with improved properties.
Post-translational lysine ac(et)ylation in health, ageing and disease
Authors: Blasl Anna-Theresa , Schulze Sabrina , Qin Chuan , Graf Leonie G. , Vogt Robert , Lammers Michael 
Published: August 2021

Abstract
The acetylation/acylation (ac(et)ylation) of lysine side chains is a dynamic post-translational modification (PTM) regulating fundamental cellular processes with implications on the organisms’ ageing process: metabolism, transcription, translation, cell proliferation, regulation of the cytoskeleton and DNA damage repair. First identified to occur on histones, later studies revealed the presence of lysine ac(et)ylation in organisms of all kingdoms of life, in proteins covering all essential cellular processes. A remarkable finding showed that the NAD+-dependent sirtuin deacetylase Sir2 has an impact on replicative lifespan in Saccharomyces cerevisiae suggesting that lysine acetylation has a direct role in the ageing process. Later studies identified sirtuins as mediators for beneficial effects of caloric/dietary restriction on the organisms’ health- or lifespan. However, the molecular mechanisms underlying these effects are only incompletely understood. Progress in mass-spectrometry, structural biology, synthetic and semi-synthetic biology deepened our understanding of this PTM. This review summarizes recent developments in the research field. It shows how lysine ac(et)ylation regulates protein function, how it is regulated enzymatically and non-enzymatically, how a dysfunction in this post-translational machinery contributes to disease development. A focus is set on sirtuins and lysine acyltransferases as these are direct sensors and mediators of the cellular metabolic state. Finally, this review highlights technological advances to study lysine ac(et)ylation.
Optimization of foaming process: drying behaviour, physicochemical, and powder properties of hot air-assisted foam-mat dried nectarine
Authors: Tekgül Yeliz 
Published: August 2021

Abstract
Nectarine powder is widely used in the industries of baking and confectionery. The production of nectarine powder can be made by several drying techniques such as spray, tray, drum, freeze, and foam mat. This study was aimed to optimize the parameters of the nectarine foaming process. Besides, hot air-assisted foam-mat drying of nectarine was carried out to evaluate the effect of different temperatures (50, 60, and 70 °C) on drying kinetics, physicochemical and powder properties of nectarine powder. Factors studied were egg albumin concentration, carboxymethyl cellulose concentration, and whipping time that varied between 10 and 30% (by weight), 0.2–0.8% (by weight), and 3–5 min, respectively. Optimum conditions were determined as 30% of egg albumin, 0.8% carboxymethyl cellulose, and a whipping time of 5 min to get maximum foam expansion, high foam stability, and minimum foam density. The drying rate and effective moisture diffusivity of nectarine foam powder increased with increasing drying temperature. Carr Index and Hauser Ratio values were in the range of 32.31–47.00 and 1.48–2.00, respectively. Foamed nectarine powder dried at 70 °C had the lowest hygroscopicity value and the highest wettability value. No significant difference was found between the powders’ porosity (p > 0.05). The powders produced at 50 °C resulted in higher total phenolic, vitamin C, and carotenoid content.
Current state and future challenges in deep space communication: A survey
Authors: Könsgen Andreas , Förster Anna 
Published: August 2021

AbstractCommunication has been crucial since the beginning of space exploration. Control information and telemetry data of the space vessels as well as voice and video communication of the crew with the ground control have to be maintained. This paper is a survey for readers new to the topic to get an overview about the current status of space communication in national agencies and standardization bodies and ongoing research in the field. It also gives a short overview about the historical development and finally summarizes the authors’ thoughts about future challenges in space communication.
A fo bont, bid ben: colonial and postcolonial ideologies in debates on renaming the Second Severn Crossing
Authors: Listewnik Marta 
Published: August 2021

Abstract
This paper analyses political and media discourse surrounding the UK government’s decision to change the name of the Second Severn Crossing, a motorway bridge over the river between Wales and England, to the Prince of Wales Bridge in order to commemorate the 70th birthday of Prince Charles. This decision, taken without the prior consultation of Welsh citizens, caused a public uproar and resulted in disputes among politicians as well as in mainstream and social media. This article explores the case of renaming this landmark construction by relating it to the concepts of colonial and postcolonial ideologies, power and national identity. A thematic analysis of media discourse and a debate in the National Assembly for Wales demonstrates how attempts to manipulate the cultural and linguistic landscape reveal political and social tensions within Welsh society, bringing to the fore current issues concerning Welsh identity.
Notes Toward an Extimate Materialism: A Reply to Graham Harman
Authors: Sbriglia Russell 
Published: August 2021

AbstractThis article mounts a defense of my and Slavoj Žižek’s co-edited anthology,Subject Lessons: Hegel, Lacan, and the Future of Materialism, against the two main criticisms of it made throughout Graham Harman’s article “The Battle of Objects and Subjects”: (1) that we and our fellow contributors are guilty of gross overgeneralization when we classify thinkers from various schools of thought – among them New Materialism, object-oriented ontology, speculative realism, and actor–network theory – under the broad rubric of the “new materialisms”; and (2) that despite our pretensions to the mantle of materialism, our Lacano-Hegelian position is actually a full-blown idealism. In responding to and attempting to refute these criticisms, I make the case that our Lacano-Hegelian model of dialectical materialism is an “extimate materialism.”
Changing People’s Preferences by the State and the Law
Authors: Porat Ariel 
Published: August 2021

Abstract
In standard economic models, two basic assumptions are made: the first, that actors are rational, and the second, that actors’ preferences are a given and exogenously determined. Behavioral economics — followed by behavioral law and economics — has questioned the first assumption. This Article challenges the second one, arguing that in many instances, social welfare should be enhanced not by maximizing satisfaction of existing preferences but by changing the preferences themselves. The Article identifies seven categories of cases where the traditional objections to intentional preference change by the state and the law lose force and argues that in these cases, such a change warrants serious consideration. It then proposes four different modes of intervention in people’s preferences, varying in intensity, on the one hand, and in the identity of their addressees, on the other, and explains the relative advantages and disadvantages of each form of intervention.
Mixed convection flow of Brinkman fluid with convective boundary condition at lower stagnation point of horizontal circular cylinder
Authors: Mohd Kanafiah Siti Farah Haryatie , Mohd Kasim Abdul Rahman , Mohd Zokri Syazwani , Al Sharifi Hussien Ali Muhammed 
Published: August 2021

Convective heat transfer occurs when heat is transferred from one level to another upon the motion of fluid. Understanding on the characteristics of fluid flow is essential since it will produce the desired output of the product. therefore, this paper examines the mixed convection flow at lower stagnation point of horizontal circular cylinder on Brinkman fluid saturated in porous region with convective boundary condition. The influence of Brinkman, mixed convection and conjugate parameter on the flow field are studied. To reduce the complexity of the equations, a suitable similarity transformation is used. The numerical results of governing equations are obtained via bvp4c tools in Matlab. The effect of mixed convection, Brinkman and conjugate parameter on the temperature and velocity profile, skin friction coefficient together with Nusselt number are analysed and portrayed in graph and table form. The velocity profile increased with improving mixed convection and conjugate value, but decreased with increasing Brinkman factor. It is also discovered that the temperature decrease when the mixed convection parameter increase. This theoretical results will benefit the researchers, particularly in the manufacturing industry, in validating experimental study data.