bluuebunny/crossref_metadata_2025_split huggingface dataset:
Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
Authors: Rana Manjul , Dong Jianrong , Robertson Matthew J. , Basil Paul , Coarfa Cristian , Weigel Nancy L. 
Published: January 2021

AbstractProstate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent. Expression of constitutively active AR variants lacking the ligand-binding domain including the variant AR-V7 contributes to this resistance. AR and AR-V7, as transcription factors, regulate many of the same genes, but also have unique activities. In this study, the capacity of the two AR isoforms to regulate splicing was examined. RNA-seq data from models that endogenously express AR and express AR-V7 in response to doxycycline were used. Both AR isoforms induced multiple changes in splicing and many changes were isoform-specific. Analyses of two endogenous genes, PGAP2 and TPD52, were performed to examine differential splicing. A novel exon that appears to be a novel transcription start site was preferentially induced by AR-V7 in PGAP2 although it is induced to a lesser extent by AR. The previously described AR induced promoter 2 usage that results in a novel protein derived from TPD52 (PrLZ) was not induced by AR-V7. AR, but not AR-V7, bound to a site proximal to promoter 2, and induction was found to depend on FOXA1.
Anthropogenic warming and intraseasonal summer monsoon variability amplify the risk of future flash droughts in India
Authors: Mishra Vimal , Aadhar Saran , Mahto Shanti Shwarup 
Published: January 2021

AbstractFlash droughts cause rapid depletion in root-zone soil moisture and severely affect crop health and irrigation water demands. However, their occurrence and impacts in the current and future climate in India remain unknown. Here we use observations and model simulations from the large ensemble of Community Earth System Model to quantify the risk of flash droughts in India. Root-zone soil moisture simulations conducted using Variable Infiltration Capacity model show that flash droughts predominantly occur during the summer monsoon season (June–September) and driven by the intraseasonal variability of monsoon rainfall. Positive temperature anomalies during the monsoon break rapidly deplete soil moisture, which is further exacerbated by the land-atmospheric feedback. The worst flash drought in the observed (1951–2016) climate occurred in 1979, affecting more than 40% of the country. The frequency of concurrent hot and dry extremes is projected to rise by about five-fold, causing approximately seven-fold increase in flash droughts like 1979 by the end of the 21st century. The increased risk of flash droughts in the future is attributed to intraseasonal variability of the summer monsoon rainfall and anthropogenic warming, which can have deleterious implications for crop production, irrigation demands, and groundwater abstraction in India.
Simulating SARS-CoV-2 epidemics by region-specific variables and modeling contact tracing app containment
Authors: Ferrari Alberto , Santus Enrico , Cirillo Davide , Ponce-de-Leon Miguel , Marino Nicola , Ferretti Maria Teresa , Santuccione Chadha Antonella , Mavridis Nikolaos , Valencia Alfonso 
Published: January 2021

AbstractTargeted contact-tracing through mobile phone apps has been proposed as an instrument to help contain the spread of COVID-19 and manage the lifting of nation-wide lock-downs currently in place in USA and Europe. However, there is an ongoing debate on its potential efficacy, especially in light of region-specific demographics. We built an expanded SIR model of COVID-19 epidemics that accounts for region-specific population densities, and we used it to test the impact of a contact-tracing app in a number of scenarios. Using demographic and mobility data from Italy and Spain, we used the model to simulate scenarios that vary in baseline contact rates, population densities, and fraction of app users in the population. Our results show that, in support of efficient isolation of symptomatic cases, app-mediated contact-tracing can successfully mitigate the epidemic even with a relatively small fraction of users, and even suppress altogether with a larger fraction of users. However, when regional differences in population density are taken into consideration, the epidemic can be significantly harder to contain in higher density areas, highlighting potential limitations of this intervention in specific contexts. This work corroborates previous results in favor of app-mediated contact-tracing as mitigation measure for COVID-19, and draws attention on the importance of region-specific demographic and mobility factors to achieve maximum efficacy in containment policies.
Burst-and-coast swimmers optimize gait by adapting unique intrinsic cycle
Authors: Li Gen , Ashraf Intesaaf , François Bill , Kolomenskiy Dmitry , Lechenault Frédéric , Godoy-Diana Ramiro , Thiria Benjamin 
Published: January 2021

AbstractThis paper addresses the physical mechanism of intermittent swimming by considering the burst-and-coast regime of fish swimming at different speeds. The burst-and-coast regime consists of a cycle with two successive phases, i.e., a phase of active undulation powered by the fish muscles followed by a passive gliding phase. Observations of real fish whose swimming gait is forced in a water flume from low to high speed regimes are performed, using a full description of the fish kinematics and mechanics. We first show that fish modulate a unique intrinsic cycle to sustain the demanded speed by modifying the bursting to coasting ratio while maintaining the duration of the cycle nearly constant. Secondly, we show using numerical simulations that the chosen kinematics by correspond to optimized gaits for swimming speeds larger than 1 body length per second.
R–R–T (resistance–resilience–transformation) typology reveals differential conservation approaches across ecosystems and time
Authors: Peterson St-Laurent Guillaume , Oakes Lauren E. , Cross Molly , Hagerman Shannon 
Published: January 2021

AbstractConservation practices during the first decade of the millennium predominantly focused on resisting changes and maintaining historical or current conditions, but ever-increasing impacts from climate change have highlighted the need for transformative action. However, little empirical evidence exists on what kinds of conservation actions aimed specifically at climate change adaptation are being implemented in practice, let alone how transformative these actions are. In response, we propose and trial a novel typology—the R–R–T scale, which improves on existing concepts of Resistance, Resilience, and Transformation—that enables the practical application of contested terms and the empirical assessment of whether and to what extent a shift toward transformative action is occurring. When applying the R–R–T scale to a case study of 104 adaptation projects funded since 2011, we find a trend towards transformation that varies across ecosystems. Our results reveal that perceptions about the acceptance of novel interventions in principle are beginning to be expressed in practice.
The GCN5: its biological functions and therapeutic potentials
Authors: Haque Md. Ezazul , Jakaria Md. , Akther Mahbuba , Cho Duk-Yeon , Kim In-Su , Choi Dong-Kug 
Published: January 2021

Abstract
General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase (HAT) and lysine acetyltransferase (KAT). As an HAT it plays a pivotal role in the epigenetic landscape and chromatin modification. Besides, GCN5 regulates a wide range of biological events such as gene regulation, cellular proliferation, metabolism and inflammation. Imbalance in the GCN5 activity has been reported in many disorders such as cancer, metabolic disorders, autoimmune disorders and neurological disorders. Therefore, unravelling the role of GCN5 in different diseases progression is a prerequisite for both understanding and developing novel therapeutic agents of these diseases. In this review, we have discussed the structural features, the biological function of GCN5 and the mechanical link with the diseases associated with its imbalance. Moreover, the present GCN5 modulators and their limitations will be presented in a medicinal chemistry perspective.
3D kinematics and age distribution of the open cluster population
Authors: Tarricq Y. , Soubiran C. , Casamiquela L. , Cantat-Gaudin T. , Chemin L. , Anders F. , Antoja T. , Romero-Gómez M. , Figueras F. , Jordi C. , Bragaglia A. , Balaguer-Núñez L. , Carrera R. , Castro-Ginard A. , Moitinho A. , Ramos P. , Bossini D. 
Published: January 2021

Context. Open clusters (OCs) trace the evolution of the Galactic disc with great accuracy. Gaia and large ground-based spectroscopic surveys make it possible to determine their properties and study their kinematics with unprecedented precision.
Aims. We study the kinematical behaviour of the OC population over time. We take advantage of the latest age determinations of OCs to investigate the correlations of the 6D phase-space coordinates and orbital properties with age. The phase-space distribution, age-velocity relation, and action distribution are compared to those of field stars. We also investigate the rotation curve of the Milky Way traced by OCs, and we compare it to that of other observational or theoretical studies.
Methods. We gathered nearly 30 000 radial velocity (RV) measurements of OC members from both Gaia-RVS data and ground-based surveys and catalogues. We computed the weighted mean RV, Galactic velocities, and orbital parameters of 1382 OCs. We investigated their distributions as a function of age and by comparison to field stars.
Results. We provide the largest RV catalogue available for OCs, half of it based on at least three members. Compared to field stars, we note that OCs are not on exactly the same arches in the radial-azimuthal velocity plane, while they seem to follow the same diagonal ridges in the Galactic radial distribution of azimuthal velocities. Velocity ellipsoids in different age bins all show a clear anisotropy. The heating rate of the OC population is similar to that of field stars for the radial and azimuthal components, but it is significantly lower for the vertical component. The rotation curve drawn by our sample of clusters shows several dips that match the wiggles derived from nonaxisymmetric models of the Galaxy. From the computation of orbits, we obtain a clear dependence of the maximum height and eccentricity on age. Finally, the orbital characteristics of the sample of clusters as shown by the action variables follow the distribution of field stars. The additional age information of the clusters indicates some (weak) age dependence of the known moving groups.
Alfvénic versus non-Alfvénic turbulence in the inner heliosphere as observed by Parker Solar Probe
Authors: Shi C. , Velli M. , Panasenco O. , Tenerani A. , Réville V. , Bale S. D. , Kasper J. , Korreck K. , Bonnell J. W. , Dudok de Wit T. , Malaspina D. M. , Goetz K. , Harvey P. R. , MacDowall R. J. , Pulupa M. , Case A. W. , Larson D. , Verniero J. L. , Livi R. , Stevens M. , Whittlesey P. , Maksimovic M. , Moncuquet M. 
Published: January 2021

Context. Parker Solar Probe (PSP) measures the magnetic field and plasma parameters of the solar wind at unprecedentedly close distances to the Sun. These data provide great opportunities to study the early-stage evolution of magnetohydrodynamic (MHD) turbulence in the solar wind.
Aims. In this study, we make use of the PSP data to explore the nature of solar wind turbulence focusing on the Alfvénic character and power spectra of the fluctuations and their dependence on the distance and context (i.e., large-scale solar wind properties), aiming to understand the role that different effects such as source properties, solar wind expansion, and stream interaction might play in determining the turbulent state.
Methods. We carried out a statistical survey of the data from the first five orbits of PSP with a focus on how the fluctuation properties at the large MHD scales vary with different solar wind streams and the distance from the Sun. A more in-depth analysis from several selected periods is also presented.
Results. Our results show that as fluctuations are transported outward by the solar wind, the magnetic field spectrum steepens while the shape of the velocity spectrum remains unchanged. The steepening process is controlled by the “age” of the turbulence, which is determined by the wind speed together with the radial distance. Statistically, faster solar wind has higher “Alfvénicity,” with a more dominant outward propagating wave component and more balanced magnetic and kinetic energies. The outward wave dominance gradually weakens with radial distance, while the excess of magnetic energy is found to be stronger as we move closer toward the Sun. We show that the turbulence properties can significantly vary from stream to stream even if these streams are of a similar speed, indicating very different origins of these streams. Especially, the slow wind that originates near the polar coronal holes has much lower Alfvénicity compared with the slow wind that originates from the active regions and pseudostreamers. We show that structures such as heliospheric current sheets and velocity shears can play an important role in modifying the properties of the turbulence.
Factors Affecting Compliance to a Gluten-Free Diet in Pediatric Populations with Celiac Disease
Authors: Macedo-Campos Vítor , Macedo-Campos Rui , Pinto-Ribeiro Filipa , Antunes Henedina 
Published: January 2021

AbstractCeliac disease (CD) is a multisystemic autoimmune disorder triggered by gluten, and the only known remedy available for this malady is a gluten-free diet (GFD). Therefore, we performed a systematic review to correlate the influence of different factors in compliance to a GFD. We searched PubMed database, from inception to April 2019. As inclusion criteria we considered population under 18 years, confirmed diagnosis of CD without related comorbidities and the study objective being the factors affecting compliance to a GFD. The variables compared were age, parent's education level, parental knowledge about CD, family type, celiac association membership, quality of life, and perception of difficulties in maintaining a GFD. We identified 1,414 articles, 35 articles were eligible for full text assessment and 12 were included in the study since they studied similar variables. Our work has found some limitations namely a variety of methods to assess GFD compliance, a limiting definition of compliance, a parental bias in data, an absence of standardization in age categories, and a majority of studies being observational in their nature. Age as well as parental knowledge of CD and family type are key factors in pediatric GFD compliance. Nevertheless environmental, social, and family factors were also related with compliance. Further studies are needed to fully disclose the causality relation between these factors and compliance.
Self-representation of people with disabilities
Authors: Kohn Ayelet 
Published: January 2021

Abstract
This paper examines the contribution of multimodal strategies in challenging aspects of public discourse about
people with disabilities. It looks into media texts that were created by people with disabilities, in which the topic of
disability is not a metaphor or a narrative prosthesis, but a demand for recognition and a call for a sincere dialogue, using
three complementary strategies: disabling the viewers, challenging dominant aesthetic norms, and ironic echoing. The paper focuses
on two autobiographical videos, a promotional video, a small corpus of paintings and a photograph, in which ironic echoing is the
dominant strategy.
Dialogical approach to a highly controlled discourse
Authors: Carcassonne Marie 
Published: January 2021

AbstractThis paper sets out the results of an analysis of a corpus of interviews with certified accountants who work or have worked for a major international audit group (one of the Big 4). It uses a dialogical and enunciative approach to show how highly controlled discourses are employed to criticize the “affective temporality” in these large firms. The interviewees all mention the difficulty of living with certain emotions within these Big 4 firms (in particular with the following “temporal emotions”: boredom with repetitive tasks, cold relationships, stress and pressure). We use the pedagogical context of data collection and the professional context of the interviewees to interpret these controlled discourses, while strongly mobilizing the responsive dimension of dialogism.
Some challenges of interdisciplinarity
Authors: Létourneau Alain 
Published: January 2021

Abstract
This piece explores dialogue analysis inside a particular ongoing collective work, a regional adaptation to climate change
research-action project in the southern part of Québec province, the Memphrémagog MRC. First, some precision is given to better understand
what it means to work in interdisciplinary contexts such as this one, continuing the development of a terminology to be able to better
identify collaboration between and with different professionals. These problems are then expressed in two case studies of dialogues as they
have been documented in the research project.
What does professional experience have to offer?
Authors: Ho Chen-En 
Published: January 2021

Abstract
This study investigated the impact of professional experience on
the process and product of sight interpreting/translation (SiT). Seventeen
experienced interpreters, with at least 150 days’ professional experience, and
18 interpreting students were recruited to conduct three tasks: silent reading,
reading aloud, and SiT. All participants had similar interpreter training
backgrounds. The data of the SiT task are reported here, with two
experienced interpreters (both AIIC members) assessing the participants’
inter­pretations on accuracy and style, which includes fluency and other
paralinguistic performance. The findings show that professional experience
contributed to higher accuracy, although there was no between-group difference
in the mean score on style, overall task time, length of the SiT output, and
mean fixation duration of each stage of reading. The experienced practitioners
exhibited more varied approaches at the beginning of the SiT task, with some
biding their time longer than the others before oral production started, but
quality was not affected. Moving along, the practitioners showed better language
flexibility in that their renditions were faster, steadier, and less disrupted
by pauses and the need to read further to maintain the flow of
interpretation.
Air shooting competition effects on visual skills depending on the sport level
Authors: Mon‐López Daniel , Bernardez‐Vilaboa Ricardo , Sillero‐Quintana Manuel , Alvarez Fernandez‐Balbuena Antonio 
Published: January 2021

ABSTRACTOlympic shooting is a sport with high demands of accuracy. Minimal visual errors could be related to performance losses. However, not all visual skills have been studied in depth in this sport. The main objectives of this study were to compare differences in shooters’ visual skills by level and to analyze the competition effect on them. Sixty‐six participants were distributed in three groups (non‐athletes, elite and non‐elite). Eleven visual variables were tested in four skills groups (visual acuity, heterophoria, accommodation functions and other visual skills). The data were collected through a pre‐ and post‐competition simulation test. The results of the study showed differences between groups by shooting sport level. In general, shooters had higher visual acuity values than non‐athletes p < .001 with large size effects (d between 1.01 and 2.35), and elite shooters presented higher values of accommodation than non‐elite shooters p < .05 with large size effects (d between 0.88 and 0.97). Furthermore, different visual skills were modified after competition depending on the shooting level. Specifically, visual accommodation skills were only improved in elite shooters. Finally, our study suggests that elite shooters employ different visual strategies or skills to non‐elite shooters and that shooting activity is closely related to some specific visual skills. This aspect should be considered by coaches in the design of optimal visual trainings and improve the shooters’ performance.Highlights
Shooters showed better acuity skills than non‐athletes.
Shooting activity seems to improve visual acuity skills, binocular visual time and eye–hand coordination in non‐elite shooters, and accommodation and eye–hand coordination in elite shooters immediately after the competition simulation.
Elite shooters employ different visual strategies or skills to non‐elite shooters.
Non‐dominant eye occlusion may benefit binocular vision recovery by inhibiting aiming action and the use of accommodative flexibility could be related to the QE during the shot.
Spectrum of the most powerful series–parallel combination of identical cells
Authors: Hong Seok-In 
Published: January 2021

Abstract
For a given total number of identical cells with internal resistance, we inquire the series–parallel combination of the cells that yields the maximum current through a load resistor linked to the combination. The aspect ratio or shape factor (number of parallel strings/number of serial cells in each string) of cell combination for the maximum load current depends on the resistance ratio (internal resistance/load resistance). Here we provide a systematic, algebraically simple and efficient way to find the (discrete) ‘spectrum’ of the shape factor for the maximum load current as a piecewise-defined function of resistance ratio. In particular, we can get the spectrum by computer programming even when the total number of series–parallel combinations is large as in the case of the electric eel. Furthermore, using the spectrum, we obtain the maximum load current as a piecewise-defined function of resistance ratio. All taken together, this article would be beneficial to university teachers and students because (i) it provides them with pedagogically useful information on the series–parallel combination of identical cells, (ii) its whole process is algebraically easy enough to understand, and (iii) it gives them a good example of using a computer programming in physics education. In addition, it is also of practical importance as the scheme introduced herein can be applied to electric vehicles whose batteries have the pack-module-cell structure.
A silicone based piezoelectric and electromagnetic hybrid vibration energy harvester
Authors: Ali Tashfeen , Khan Farid Ullah 
Published: January 2021

Abstract
This paper describes the investigation of a novel low-cost silicone-based hybrid vibration energy harvester (SHVEH) for converting machine vibrations into useful electrical power for wireless sensor nodes. Due to a novel fabrication technique, the harvester has the benefit of incorporating two transduction mechanisms (electromagnetic and piezoelectric) into a single silicone housing for improved output power. In the devised fabrication technique, water-soluble tablets are used to develop a cavity inside the silicone structure for an embedded magnet to vibrate in. The developed device was characterized inside the lab at different acceleration levels. The SHVEH was found to be capable of delivering a combined output power of 1.12 mW and a power density of 52 µW cm−3. The SHVEH was able to deliver maximum open circuit voltages of 3 V and 28 mV AC via the piezoelectric and electromagnetic portions, respectively, at a resonant frequency of 110 Hz. Furthermore, after connecting the SHVEH to rectifier circuitry, the DC voltage levels obtained were 3.5 V and 35 mV from the piezoelectric and electromagnetic portions, respectively.