bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Heteronuclear Arrays from IrIII‐Metalloligand and CoII Showing Coexistence of Slow Magnetization Relaxation and Photoluminescence
Authors: Fan Kun , Bao Song‐Song , Yu Zi‐Wen , Huang Xin‐Da , Liu Yu‐Jie , Kurmoo Mohamedally , Zheng Li‐Min 
Published: December 2021

Comprehensive SummaryThree heteronuclear IrIII‐CoII arrays, [Co(H2O)6]2[Ir(ppyCOO)(ppyCOOH)(bpy)]2[Ir(ppyCOO)2(bpy)]2(NO3)2⋅10.5H2O (2), [Co(H2O)6]{Co(H2O)4[Ir(ppyCOO)2(bpy)]2}[Ir(ppyCOO)2(bpy)]2⋅15H2O (3) and {Co(H2O)2[Ir(ppyCOO)2(bpy)]2}⋅2CH3OH⋅3H2O (4), have been synthesized by combining paramagnetic CoII ion with luminescent IrIII‐metalloligand, [Ir(ppyCOOH)2(bpy)][Ir(ppyCOO)2(bpy)]⋅5H2O (1), where ppyCOOH = 3‐(pyridin‐2‐yl)benzoic acid and bpy = 2,2'‐bipyridyl. Owing to the variable charged states of compound 1 at different pH, compounds 2 and 3 are discrete ionic complexes containing hydrated Co2+ cations and deprotonated [Ir(ppyCOO)2(bpy)]– anions as well as coexisting neutral [Ir(ppyCOO)(ppyCOOH)(bpy)] (for 2) or Co(H2O)4[Ir(ppyCOO)2(bpy)]2 trinuclear molecule (for 3). Whereas compound 4 consists of self‐assembled two‐dimensional coordination polymer with Co‐metalloligand dative bonds. The hexa‐coordinated CoII cores in all complexes display octahedral geometries with varying degrees of distortion. In a bias dc field, the ac susceptibilities for 2—4 reveal slow magnetic relaxation. Moreover, the solid‐state phosphorescence is observed for compounds 2 and 3 due to weak supramolecular interaction between CoII ion and Ir‐moiety but is severely quenched for 4, where the Co center is strongly connected to the metalloligand. To the best of our knowledge, this is the first report of Ir‐Co systems showing both slow magnetization relaxation and photoluminescence.
Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review
Authors: Li Jia‐Xin , Dong Rui‐Jia , Zeng Yue‐Ping 
Published: December 2021

AbstractBackgroundAtopic dermatitis (AD) is a chronic, pruritic, immune‐mediated inflammatory disease. Developments in basic science and clinical research have increased our understanding of AD. Although pain as a symptom of AD is underemphasized in previous studies, multiple researchers address pain as a frequent burden of AD. However, the exact role of pain in AD is not fully understood.AimsOur review aimed to summarize the current evidence focusing on characteristics, mechanism, and management of pain in AD.Materials & MethodsWe conducted a thorough literature review in the PubMed database to figure out different aspects discussing pain in AD, including pain symptoms, burden, the relationship between pain and itch, mechanism, and pain management in AD.Results and ConclusionAD patients affected by skin pain vary from 42.7%‐92.2% with remarkable intensity and heavy burden. Skin pain and itch interacted both in symptoms and mechanisms. Atopic skin with the impaired barrier, neurogenic inflammation mediators, peripheral and central sensitization of pain may possibly explain pain mechanism in AD. Future research is needed to clarify the commonality and disparity of pain and itch in AD in order to seek efficacious medications and treatment.
The association of asthma, atopic dermatitis, and allergic rhinitis with peripartum mental disorders
Authors: Ren Tai , Chen Jiawen , Yu Yongfu , He Hua , Zhang Jun , Li Fei , Svendsen Katrine , Obel Carsten , Wang Hui , Li Jiong 
Published: December 2021

AbstractBackgroundAtopic diseases are characterized by dysregulated inflammatory response, which may incur the onset of peripartum mental disorders, but the impact remains unknown. This study examined whether and to what extent the history of atopic diseases is associated with newly onset peripartum mental disorders.MethodsUsing population‐based registries, we identified all primiparous women who gave birth to live singletons in Denmark during 1978–2016 (n = 937,422). The exposure was hospital contact due to the three major types of atopic diseases—asthma, atopic dermatitis, and allergic rhinitis—before conception. The primary outcome was any hospital contact for mental disorder during pregnancy and 1‐year postpartum, which was further classified into affective disorders, neurotic, stress‐related and somatoform disorders, and substance abuse. The follow‐up started from the date of conception and ended at the date of the first diagnosis of mental disorders, 1‐year postpartum, death, emigration, or December 31, 2016, whichever came first. Cox regression was used, adjusted for calendar year, age at childbirth, education, residence, and Charlson comorbidity index.ResultsA total of 24,016 (2.6%) women received diagnosis of at least one of the three atopic diseases before conception (asthma, 1.7%; atopic dermatitis, 0.6%; and allergic rhinitis, 0.8%). Exposure to asthma, atopic dermatitis, or allergic rhinitis was associated with a 37% increased overall risk of peripartum mental disorders (hazard ratio [HR], 1.37; 95% confidence interval [CI], 1.27–1.49). Higher risks were observed among women with more frequent hospital contacts for atopic disease (HR, 1.80; 95% CI, 1.37–2.35; ≥5 times), and with recent hospital contacts for atopic disease (HR, 1.74; 95% CI, 1.48–2.06; within 2 years before conception). Specific associations were observed between asthma and neurotic, stress‐related and somatoform disorders (HR, 1.40; 95% CI, 1.21–1.62), and between atopic dermatitis and substance abuse (HR, 1.62; 95% CI, 1.12–2.34).ConclusionsHistory of asthma, atopic dermatitis, and allergic rhinitis before conception was associated with increased risks of peripartum mental disorders. Women who have atopic diseases before pregnancy may benefit from systematic mental health monitoring.
Synthesis of Bitopic Ligands as Potent Dopamine D2 Receptor Agonists
Authors: Qian Mingcheng , Zhou Kuo , Wu Yi , Luo Zhijie , Xiao Zhekai , Sun Jingjing , Zeng Siyu , Yao Yi , Zhao Shuai , Chen Xin 
Published: December 2021

AbstractIn this study, we designed and synthesized twelve bitopic ligands as dopamine D2 receptor (D2R) agonists. The forskolin‐induced cAMP accumulation assay revealed that all the finial compounds are able to activate D2R. Furthermore, bitopic ligand N‐((trans)‐4‐(((2,3‐dihydro‐1H‐inden‐2‐yl)(propyl)amino)methyl)cyclo‐hexyl)‐1H‐pyrrolo[2,3‐b]pyridine‐2‐carboxamide (11 b) showed 21‐fold higher potency than lead compound propyl aminoindane (2) and 17‐fold higher subtype selectivity for D2R over D4R, indicating that the optimal length of spacer affects the D2R functionality. Molecular modeling study exhibited that 11 b formed an electrostatic interaction and two H‐bonds with amino acid Asp114, which contributes significantly to the D2R functional activity. Taken together, we discovered a bitopic ligand 11 b as potent D2R agonist, which may be used as a tool compound for further study.
Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy
Authors: Gündüz Ezel Öztürk , Gedik M. Emre , Günaydın Gürcan , Okutan Elif 
Published: December 2021

AbstractNanotheranostic tailor‐made carriers are potent platforms for the treatment of cancer that propound a number of advantages over conventional agents for photodynamic therapy (PDT). Herein, four new heavy atom free amphiphilic glucose‐BODIPY‐fullerene dyads (14–17) endowed with carbohydrate units in the styryl units, which can also form nanomicelles (14–17NM) with Tween 80 for PDT are reported. Glucose‐BODIPY‐fullerene systems (14–17) and related nanomicelles (14‐17NM) have been prepared to emcee efficient singlet oxygen generation upon light irradiation. In vitro anti‐tumor effects of the compounds 14–17 and 14–17NM in the presence of light and in darkness have been investigated with K562 human chronic myelogenous leukemia suspension cells. Anti‐tumor toxicity upon light irradiation was due to the formation of singlet oxygen and reactive oxygen species (ROS). This study may provide an accomplished example of efficient PDT applications based on nanovehicles fabricated with universal spin converter, fullerene, light harvesting unit, BODIPY dyes conjugated with targeting units to fight against cancer.
Modified jackknife Kibria–Lukman estimator for the Poisson regression model
Authors: Oranye Henrietta Ebele , Ugwuowo Fidelis Ifeanyi 
Published: December 2021

AbstractPoisson regression is one of the methods to analyze count data and, the regression parameters are usually estimated using the maximum likelihood (ML) method. However, the ML method is sensitive to multicollinearity. Multicollinearity occurs when there is linear dependency among the explanatory variables. Multicollinearity often leads to unstable maximum likelihood estimates. In this article, we developed modified jackknifed Poisson Kibria–Lukman (MJPKL) estimator to mitigate multicollinearity in the Poisson regression model. We theoretically compared the MJPKL estimator with some existing estimators and obtained the condition for the superiority of MJPKL. A simulation study and real‐life application were conducted to compare the performance of the estimators. It is evident from the simulation and real‐life results that the modified jackknifed Poisson K‐L estimator (MJPKLE) gives better results than other estimators under some conditions. Finally, the MJPKL estimator reduces the bias of the PKL estimator and dominates every estimator considered in this article.
Straightforward Access to Terminally Disubstituted Electron‐Deficient Alkylidene Cyclopent‐2‐en‐4‐ones through Olefination with α‐Carbonyl and α‐Cyano Secondary Alkyl Sulfones
Authors: Trifonov Lena , Rothstein Ayelet , Korshin Edward E. , Viskind Olga , Afri Michal , Leitus Gregory , Palczewski Krzysztof , Gruzman Arie 
Published: December 2021

AbstractHerein we report on a simplified synthesis of scarcely explored, terminally disubstituted electron‐poor alkylidene cyclopent‐2‐en‐4‐ones through uncommon olefination. Secondary sulfones, activated by electron‐withdrawing groups at the adjacent carbon atom, undergo K2CO3‐promoted coupling with 4‐acyloxy‐ and 4‐tert‐butyldimethylsilyloxycyclopent‐2‐en‐1‐ones giving directly, or after a separate dehydrosulfinylation step, alkylidene cyclopent‐2‐en‐4‐ones. A plausible mechanism for these transformations is proposed. Initially, β‐arylsulfonyl esters as well as their acetyl or nitrile analogues are allylated by cyclopentenone derivatives via a tandem Michael addition of α‐sulfonyl carbanions followed by proton migration and retro‐Michael‐type O‐nucleofuge elimination. The primary allylation products are formed as two diastereomers whose configuration and conformation were elucidated using single crystal X‐ray diffraction and NMR spectroscopy. Regardless of stereochemistry, both sets of diastereomers are subjected to Zaitsev‐type retro‐Michael vinylogous dehydrosulfinylation under either basic or thermal silica gel promoted conditions resulting in E/Z‐alkylidene cyclopent‐2‐en‐4‐ones. In these reactions activated sulfones serve as bearing electron‐withdrawing group alkylidene anion‐radical synthons, whereas 4‐oxy‐substituted cyclopentenones represent cyclopent‐2‐en‐4‐one cation‐radical surrogates.
In vitro dielectrophoresis of HEK cell migration for stimulating chronic wound epithelialization
Authors: Deivasigamani Revathy , Abdul Nasir Nur Shahira , Mohamed Mohd Ambri , Buyong Muhamad Ramdzan 
Published: December 2021

AbstractThis article describes a dielectrophoresis (DEP)‐based simulation and experimental study of human epidermal keratinocyte (HEK) cells for wounded skin cell migration toward rapid epithelialization. MyDEP is a standalone software designed specifically to study dielectric particles and cell response to an alternating current (AC) electric field. This method demonstrated that negative dielectrophoresis (NDEP) occurs in HEK cells at a wide frequency range in highly conductive medium. The finite element method was used to characterize particle trajectory based on DEP and drag force. The performance of the system was assessed using HEK cells in a highly conductive EpiLife suspending medium. The DEP experiment was performed by applying sinusoidal wave AC potential at the peak‐to‐peak voltage of 10 V in a tapered aluminum microelectrode array from 100 kHz to 1 MHz. We experimentally observed the occurrence of NDEP, which attracted HEK cells toward the local electric field minima in the region of interest. The DIPP‐MotionV software was used to track cell migration in the prerecorded video via an automatic marker and estimate the average speed and acceleration of the cells. The results showed that HEK cell migration was accomplished approximately at 6.43 μm/s at 100 kHz with 10 V, and FDEP caused the cells to migrate and align at the target position, which resulted in faster wound closures because of the application of an electric field frequency to HEK cells in random locations.
Evaluation of Capping Materials to Reduce Zinc Flux from Sediments in a Former Mining Pit Lake
Authors: Cervi Eduardo Cimino , Hudson Michelle , Rentschler Alison , Clark Sean , Brown Steven S. , Burton G. Allen 
Published: December 2021

Abstract
Wilson Mine is a former vanadium mine site located in the Ouachita Mountains near Hot Springs, Arkansas. The site, which drains via two streams to Lake Catherine, has undergone extensive reclamation to significantly reduce groundwater and surface water contact with mine spoils. One of the streams passes through a former mine pit forming East Wilson Pond, and flux from pit lake sediments can result in elevated metal, that is, zinc (Zn), concentrations in overlying water. To mitigate potential risks, an investigation was conducted to evaluate the efficacy of capping materials for partitioning Zn-contaminated sediments from overlying water in East Wilson Pond. A 28-day laboratory study compared the effectiveness of capping materials including combinations of limestone, bentonite clay, and gravel for mitigating Zn flux, including under reasonable worst-case conditions (pH 5.5) encountered in the hypolimnion. Dissolved Zn was monitored over time in overlying water and in sediment porewaters within untreated controls and within the capping layer of treated systems. The use of limestone and/or bentonite clay improved buffering capacity compared to the noncapped control, and pH declined gradually but only modestly in the overlying water and porewater of all treated systems. Concentrations of Zn in overlying water of the noncapped control increased from approximately 30 to 100 µg/L during the study period, while concentrations in the overlying water and porewater of systems containing capping materials remained low (10–30 µg/L). The results demonstrated the effectiveness of the capping materials for neutralizing pH and reducing Zn flux, and a three-layer cap consisting of limestone (top) + bentonite clay (middle) + gravel (bottom) was determined to be most effective. These results were used to inform the selection of materials for the application of a cap to reduce Zn flux from the pit lake sediments. Environ Toxicol Chem 2022;41:193–200. © 2021 SETAC
Sequana I: Struggling with section 423 of the Insolvency Act 1986
Authors: Bork Reinhard 
Published: December 2021

AbstractThis article deals with the Court of Appeal's decision in Sequana, particularly with its comments on sec. 423 IA 1986. It puts this norm in relation to other appearances of the actio pauliana in national insolvency laws and shows that sec. 423 IA 1986 is shaped rather uniquely, which makes its application unnecessarily difficult.
Differential expression of synaptophysin and its functional implication under conditions of both contused and transected spinal cord injury
Authors: Yuan Hao , Chen Zhi‐Wei , Dong Xiu‐Juan , Zhou Long‐Hui , Sun Zhen‐Wu , Liu Jian 
Published: December 2021

ObjectiveThis study was designed to investigate the effect of changes of synaptophysin in the spinal cord contusion (SCC) model and spinal cord transection (SCT) model, and collect more evidence about the role of synaptophysin for the treatment of spinal cord injury (SCI).MethodsHealthy Sprague‐Dawley rats were randomly divided into sham, SCC, and SCT groups. SCT model was induced at T10 cord transection, while SCC model was established through Allen's method. Motor function of hind limbs was evaluated with Basso, Beattie and Bresnahan (BBB) locomotor scale. Sensory function was indicated by the mechanical nociceptive withdrawal responses using paw withdrawal test and thermal hyperalgesia with tail‐flick latency. A quantitative real‐time polymerase chain reaction was used to detect the expression of synaptophysin on the level of mRNA. The location of synaptophysin in the spinal cord was detected with immunofluorescence.ResultsThe BBB score and expression level of mRNA coding synaptophysin in the SCT and SCC groups were both lower than those in the sham group; while the tail‐flick latency and threshold force were the highest in the SCT group, and the mRNA level of synaptophysin is the lowest, also. Synaptophysin immunostaining showed that it is mainly expressed in the spinal cord matter, scattered in the dorsal horn and anterior horn.ConclusionDifferential expression of synaptophysin in SCC and SCI models cause different dysfunction in behavior, especially in sensory function, suggesting that synaptophysin may be directly and differently related to sensory function remodeling in different SCI conditions.
The impact of excluded providers on Medicare beneficiaries’ mental health care
Authors: Fullen Matthew C. , Dolbin‐MacNab Megan L. , Wiley Jonathan D. , Brossoie Nancy , Lawson Gerard 
Published: December 2021

AbstractMental health conditions are relatively common among Medicare beneficiaries. Yet, Medicare provider eligibility was last updated in 1989, raising concerns about beneficiaries’ access to mental health care in the United States. Beneficiaries are currently restricted from accessing mental health services provided by licensed professional counselors and licensed marriage and family therapists. Little is known about the impact of this Medicare mental health coverage gap (MMHCG) on Medicare beneficiaries. Hermeneutic phenomenology was used to analyze semistructured interviews with 18 beneficiaries who had attempted to access mental health care but were limited due to the MMHCG. Three themes emerged: (a) exasperating experiences with the MMHCG, (b) the MMHCG compounds barriers to mental health care, and (c) Medicare as a flawed system. These findings suggest current Medicare mental health policy interferes with beneficiaries’ access to needed mental health services. Implications for the counseling profession are described.
The relationship of COVID‐19 traumatic stress, cumulative trauma, and race to posttraumatic stress disorder symptoms
Authors: Ashby Jeffrey S. , Rice Kenneth G. , Kira Ibrahim A. , Davari Jaleh 
Published: December 2021

AbstractThe purpose of this study was to test if coronavirus disease 2019 (COVID‐19) traumatic stress predicts posttraumatic stress disorder (PTSD) symptoms after cumulative trauma and whether there is a three‐way interaction between COVID‐19 traumatic stress, cumulative trauma, and race in the prediction of PTSD. Using a cross‐sectional design, a diverse sample of 745 participants completed measures of cumulative trauma, COVID‐19 traumatic stress, and PTSD. COVID‐19 traumatic stress accounted for a significant amount of the variance in PTSD above and beyond cumulative trauma. A significant interaction effect was found, indicating that the effect of COVID‐19 traumatic stress in predicting PTSD varied as a function of cumulative trauma and that the effects of that interaction were different for Asians and Whites. There were generally comparable associations between COVID‐19 traumatic stress and PTSD at low and high levels of cumulative trauma across most racial groups. However, for Asians, higher levels of cumulative trauma did not worsen the PTSD outcome as a function of COVID Traumatic Stress but did at low levels of cumulative trauma.
Membrane fouling and removal performance of submerged aerobic membrane bioreactors: a comparative study of optimizing operational conditions and membrane modification
Authors: Oghyanous Farid A , Etemadi Habib , Yegani Reza , Ghofrani Borhan 
Published: December 2021

AbstractBACKGROUNDThe effects of sludge retention time, organic loading rate, specific aeration demand per membrane area (SADm) and exploiting poly(vinyl chloride)/polycarbonate/modified silver nanoparticles (PVC/PC/MAg) nanocomposite membrane in membrane fouling and removal performance of submerged membrane bioreactors (SMBRs) were compared. A reference membrane bioreactor (R‐SMBR) having a pure PVC/PC hollow fiber membrane module and no operational condition improvement was used as a reference for comparison.RESULTSThe results revealed that all of the parameters had a considerable influence on improving membrane fouling, among which optimizing SADm and installing nanocomposite membranes in the SMBRs had comparable performances. Although the nanocomposite membrane had excellent potential to boost the membrane flux up to 62% in comparison with the R‐SMBR, it did not play any noticeable roles in rectifying the removal efficiency of the SMBR. On the other hand, not only did SADm increase the membrane flux up to 55%, but it also increased about 5% of COD and 3% of NH4+‐N removal.CONCLUSIONSSludge characteristics were not affected by membrane modification since the concentration of extracellular polymeric substances, soluble microbial products and mean particle size were 110 ± 1 mg g−1 VSS, 54 ± 1 mg L−1 and 50 μm, respectively, for both the R‐SMBR and the SMBR in which the modified membrane was installed. However, the operational parameters could also modify the treatment performance of the SMBRs by positively impacting on sludge characteristics besides mitigating membrane fouling. © 2021 Society of Chemical Industry (SCI).
Binding of phosphatidylserine‐positive microparticles by PBMCs classifies disease severity in COVID‐19 patients
Authors: Rausch Lisa , Lutz Konstantin , Schifferer Martina , Winheim Elena , Gruber Rudi , Oesterhaus Elina F. , Rinke Linus , Hellmuth Johannes C. , Scherer Clemens , Muenchhoff Maximilian , Mandel Christopher , Bergwelt‐Baildon Michael , Simons Mikael , Straub Tobias , Krug Anne B. , Kranich Jan , Brocker Thomas 
Published: December 2021

AbstractInfection with SARS‐CoV‐2 is associated with thromboinflammation, involving thrombotic and inflammatory responses, in many COVID‐19 patients. In addition, immune dysfunction occurs in patients characterised by T cell exhaustion and severe lymphopenia. We investigated the distribution of phosphatidylserine (PS), a marker of dying cells, activated platelets and platelet‐derived microparticles (PMP), during the clinical course of COVID‐19. We found an unexpectedly high amount of blood cells loaded with PS+ PMPs for weeks after the initial COVID‐19 diagnosis. Elevated frequencies of PS+PMP+ PBMCs correlated strongly with increasing disease severity. As a marker, PS outperformed established laboratory markers for inflammation, leucocyte composition and coagulation, currently used for COVID‐19 clinical scoring. PS+ PMPs preferentially bound to CD8+ T cells with gene expression signatures of proliferating effector rather than memory T cells. As PS+ PMPs carried programmed death‐ligand 1 (PD‐L1), they may affect T cell expansion or function. Our data provide a novel marker for disease severity and show that PS, which can trigger the blood coagulation cascade, the complement system, and inflammation, resides on activated immune cells. Therefore, PS may serve as a beacon to attract thromboinflammatory processes towards lymphocytes and cause immune dysfunction in COVID‐19.