bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Magnetic Mineral Assemblages in Clinkers: Potential Tools for Full Vector Paleomagnetic Studies
Authors: Sprain Courtney J. , Feinberg Joshua M. , Lamers Riley , Bono Richard K. 
Published: September 2021

AbstractHigh‐quality paleointensity data are essential for improving our understanding of the geomagnetic field; however, it is challenging to find materials that reliably record full vector magnetization going back in time. Here, we examine a new candidate material for paleointensity studies: clinkers, which are rocks that have been baked, metamorphosed, or melted by underlying coal seam fires. Previous studies conducted on clinkers suggest that they may be high‐fidelity magnetic field recorders. However, due to the inhomogeneity of clinker deposits and limited scope of previous studies, it is unknown under what conditions these conclusions hold true. To better assess this, we quantified the variation of magnetic properties within clinker deposits collected from the Powder River Basin, Montana, as a function of lithology, oxidation state, distance from the coal seam, and location. Our results indicate that the clinker products contain three main magnetic minerals: magnetite, hematite, and the rare ε‐Fe2O3. Clinker lithology was found to be the primary control on magnetic mineralogy, where strongly baked sediment and porcellanite are dominated by varying proportions of hematite, ε‐Fe2O3, and magnetite, and paralavas are dominated by low‐Ti magnetite. All clinker materials are thermally stable and likely experienced temperatures in excess of the magnetite Curie temperature. Grain size analysis indicates that the magnetic particles in all clinker materials are amenable to high‐quality paleointensity study. In total, our study confirms that clinkers should be reliable full vector paleomagnetic recorders.
Impact of Source Variability and Hydrodynamic Forces on the Distribution, Transport, and Burial of Sedimentary Organic Matter in a Tropical Coastal Margin: The Gulf of Thailand
Authors: Bai Yazhi , Hu Limin , Wu Bin , Qiao Shuqing , Fan Dejiang , Liu Shengfa , Yang Gang , Liu Jihua , Kornkanitnan Narumol , Khokiattiwong Somkiat , Shi Xuefa 
Published: September 2021

AbstractCarbon cycling in the tropical margin is more extensive compared with other regions of the world. The goal of this study was to better understand the origins, transport, and burial of sedimentary organic matter (SOM) in the Gulf of Thailand (GOT) from the coastal margin of Southeast (SE) Asia, which serve as a major depository of ﬁne‐grained sediments and the associated organic carbon (OC). The results revealed a variety of organic matter (OM) inputs and the selective transport of fine sediment, resulting in preferential dispersal of terrigenous SOM in the GOT. Bulk OC indices with low carbon/nitrogen ratios and enriched stable carbon isotope ratios (−24.2‰ to −20.4‰, and mean −21.4 ± 0.56‰) are likely related to the presence of marine‐derived OM and anthropogenic interference. A binary mixing model further clarified the significant contributions of terrestrial derived‐OM within the upper and central GOT. The n‐alkane compositions and principal component analysis indicated that a majority of the terrigenous SOM settles within the estuary in the upper GOT, while a selective dispersal of land‐based SOM through long‐distance transport toward the modern depocenter in the lower GOT. The characteristics of lower molecular weight n‐alkanes also suggest anthropogenic OM input from petroleum‐related contributions. Altogether, the depositional patterns and spatial heterogeneity of the SOM indicated by both the bulk and molecular signatures reveal the important roles of source variability and the selective dispersal of land‐based OM on the supply and accumulation of OC in the tropical coastal margin.
Eliminating viscosity bias in lateral flow tests
Authors: Kainz Daniel M. , Breiner Bastian J. , Früh Susanna M. , Hutzenlaub Tobias , Zengerle Roland , Paust Nils 
Published: September 2021

AbstractDespite the widespread application of point-of-care lateral flow tests, the viscosity dependence of these assay results remains a significant challenge. Here, we employ centrifugal microfluidic flow control through the nitrocellulose membrane of the strip to eliminate the viscosity bias. The key feature is the balancing of the sample flow into the cassette of the lateral flow test with the air flow out of the cassette. A viscosity-independent flow rate of 3.01 ± 0.18 µl/min (±6%) is demonstrated for samples with viscosities ranging from 1.1 mPas to 24 mPas, a factor greater than 20. In a model human IgG lateral flow assay, signal-intensity shifts caused by varying the sample viscosity from 1.1 mPas to 2.3 mPas could be reduced by more than 84%.
LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6high cervical cancer stem cells
Authors: Feng Qian , Li Shan , Ma Hong-Mei , Yang Wen-Ting , Zheng Peng-Sheng 
Published: September 2021

AbstractThe leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be a stem cell marker in many normal tissues and promotes tissue development, regeneration, and repair. LGR6 is also related to the initiation and progression of some malignant tumors. However, the role of LGR6 in cervical cancer has not been reported. Here, immunohistochemistry and western blotting showed that LGR6 was significantly upregulated in cervical cancer, compared with the normal cervix. By analyzing The Cancer Genome Atlas database, LGR6 was found to be correlated with a poor prognosis of cervical cancer. Then, a small population of LGR6high cells isolated by using the fluorescence-activated cell sorting exhibited enhanced properties of cancer stem cells including self-renewal, differentiation, and tumorigenicity. Moreover, RNA sequencing revealed that LGR6 was correlated with the Wnt signaling pathway and TOP/FOP, reverse transcription-PCR, and western blotting further proved that LGR6 could activate the Wnt/β-catenin signaling pathway. Interestingly, LGR6 upregulated the expression of TCF7L2 by activating the Wnt/β-catenin pathway. Then, TCF7L2 combining with β-catenin in the nucleus enhanced LGR6 transcription by binding the promoter of LGR6, which further activated the Wnt signaling to form a positive feedback loop. Thus, our study demonstrated that LGR6 activated a novel β-catenin/TCF7L2/LGR6-positive feedback loop in LGR6high cervical cancer stem cells (CSCs), which provided a new therapeutic strategy for targeting cervical CSCs to improve the prognosis of cervical cancer patients.
Subthalamic and pallidal deep brain stimulation for Parkinson’s disease—meta-analysis of outcomes
Authors: Lachenmayer M. Lenard , Mürset Melina , Antih Nicolas , Debove Ines , Muellner Julia , Bompart Maëlys , Schlaeppi Janine-Ai , Nowacki Andreas , You Hana , Michelis Joan P. , Dransart Alain , Pollo Claudio , Deuschl Guenther , Krack Paul 
Published: September 2021

AbstractAlthough deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the subthalamic nucleus (STN) has become an established treatment for Parkinson’s disease (PD), a recent meta-analysis of outcomes is lacking. To address this gap, we performed a meta-analysis of bilateral STN- and GPi-DBS studies published from 1990-08/2019. Studies with ≥10 subjects reporting Unified Parkinson’s Disease Rating Scale (UPDRS) III motor scores at baseline and 6–12 months follow-up were included. Several outcome variables were analyzed and adverse events (AE) were summarized. 39 STN studies (2035 subjects) and 5 GPi studies (292 subjects) were eligible. UPDRS-II score after surgery in the stimulation-ON/medication-OFF state compared to preoperative medication-OFF state improved by 47% with STN-DBS and 18.5% with GPi-DBS. UPDRS-III score improved by 50.5% with STN-DBS and 29.8% with GPi-DBS. STN-DBS improved dyskinesia by 64%, daily OFF time by 69.1%, and quality of life measured by PDQ-39 by 22.2%, while Levodopa Equivalent Daily Dose (LEDD) was reduced by 50.0%. For GPi-DBS information regarding dyskinesia, OFF time, PDQ-39 and LEDD was insufficient for further analysis. Correlation analysis showed that preoperative L-dopa responsiveness was highly predictive of the STN-DBS motor outcome across all studies. Most common surgery-related AE were infection (5.1%) and intracranial hemorrhage (3.1%). Despite a series of technological advances, outcomes of modern surgery are still comparable with those of the early days of DBS. Recent changes in target selection with a preference of GPi in elderly patients with cognitive deficits and more psychiatric comorbidities require more published data for validation.
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs
Authors: Loubalova Zuzana , Fulka Helena , Horvat Filip , Pasulka Josef , Malik Radek , Hirose Michiko , Ogura Atsuo , Svoboda Petr 
Published: September 2021

AbstractPIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons. Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are essential for male but not for female fertility. Here, we report that the role of the piRNA pathway substantially differs in golden hamsters (Mesocricetus auratus), the piRNA pathway setup of which more closely resembles that of other mammals, including humans. The loss of the Mov10l1 RNA helicase—an essential piRNA biogenesis factor—leads to striking phenotypes in both sexes. In contrast to mice, female Mov10l1–/– hamsters are sterile because their oocytes do not sustain zygotic development. Furthermore, Mov10l1–/– male hamsters have impaired establishment of spermatogonia accompanied by transcriptome dysregulation and an expression surge of a young retrotransposon subfamily. Our results show that the mammalian piRNA pathway has essential roles in both sexes and its adaptive nature allows it to manage emerging genomic threats and acquire new critical roles in the germline.
Automated predictive analytics tool for rainfall forecasting
Authors: Raval Maulin , Sivashanmugam Pavithra , Pham Vu , Gohel Hardik , Kaushik Ajeet , Wan Yun 
Published: September 2021

AbstractAustralia faces a dryness disaster whose impact may be mitigated by rainfall prediction. Being an incredibly challenging task, yet accurate prediction of rainfall plays an enormous role in policy making, decision making and organizing sustainable water resource systems. The ability to accurately predict rainfall patterns empowers civilizations. Though short-term rainfall predictions are provided by meteorological systems, long-term prediction of rainfall is challenging and has a lot of factors that lead to uncertainty. Historically, various researchers have experimented with several machine learning techniques in rainfall prediction with given weather conditions. However, in places like Australia where the climate is variable, finding the best method to model the complex rainfall process is a major challenge. The aim of this paper is to: (a) predict rainfall using machine learning algorithms and comparing the performance of different models. (b) Develop an optimized neural network and develop a prediction model using the neural network (c) to do a comparative study of new and existing prediction techniques using Australian rainfall data. In this paper, rainfall data collected over a span of ten years from 2007 to 2017, with the input from 26 geographically diverse locations have been used to develop the predictive models. The data was divided into training and testing sets for validation purposes. The results show that both traditional and neural network-based machine learning models can predict rainfall with more precision.
Muographic monitoring of hydrogeomorphic changes induced by post-eruptive lahars and erosion of Sakurajima volcano
Authors: Oláh László , Tanaka Hiroyuki K. M. , Hamar Gergő 
Published: September 2021

AbstractPost-eruptive destabilization of volcanic edifices by gravity driven debris flows or erosion can catastrophically impact the landscapes, economies and human societies surrounding active volcanoes. In this work, we propose cosmic-ray muon imaging (muography) as a tool for the remote monitoring of hydrogeomorphic responses to volcano landscape disturbances. We conducted the muographic monitoring of Sakurajima volcano, Kyushu, Japan and measured continuous post-eruptive activity with over 30 lahars per year. The sensitive surface area of the Multi-Wire-Proportional-Chamber-based Muography Observation System was upgraded to 7.67 m$$^2$$

2

; this made it possible for the density of tephra within the crater region to be measured in 40 days. We observed the muon flux decrease from 10 to 40% through the different regions of the crater from September 2019 to October 2020 due to the continuous deposition of tephra fallouts. In spite of the long-term mass increase, significant mass decreases were also observed after the onsets of rain-triggered lahars that induced the erosion of sedimented tephra. The first muographic observation of these post-eruptive phenomena demonstrate that this passive imaging technique has the potential to contribute to the assessment of indirect volcanic hazards.
Superior tunable photocatalytic properties for water splitting in two dimensional GeC/SiC van der Waals heterobilayers
Authors: Islam Md. Rasidul , Islam Md. Sherajul , Mitul Abu Farzan , Mojumder Md. Rayid Hasan , Islam A. S. M. Jannatul , Stampfl Catherine , Park Jeongwon 
Published: September 2021

AbstractThe photocatalytic characteristics of two-dimensional (2D) GeC-based van der Waals heterobilayers (vdW-HBL) are systematically investigated to determine the amount of hydrogen (H2) fuel generated by water splitting. We propose several vdW-HBL structures consisting of 2D-GeC and 2D-SiC with exceptional and tunable optoelectronic properties. The structures exhibit a negative interlayer binding energy and non-negative phonon frequencies, showing that the structures are dynamically stable. The electronic properties of the HBLs depend on the stacking configuration, where the HBLs exhibit direct bandgap values of 1.978 eV, 2.278 eV, and 2.686 eV. The measured absorption coefficients for the HBLs are over ~ 105 cm−1, surpassing the prevalent conversion efficiency of optoelectronic materials. In the absence of external strain, the absorption coefficient for the HBLs reaches around 1 × 106 cm−1. With applied strain, absorption peaks are increased to ~ 3.5 times greater in value than the unstrained HBLs. Furthermore, the HBLs exhibit dynamically controllable bandgaps via the application of biaxial strain. A decrease in the bandgap occurs for both the HBLs when applied biaxial strain changes from the compressive to tensile strain. For + 4% tensile strain, the structure I become unsuitable for photocatalytic water splitting. However, in the biaxial strain range of − 6% to + 6%, both structure II and structure III have a sufficiently higher kinetic potential for demonstrating photocatalytic water-splitting activity in the region of UV to the visible in the light spectrum. These promising properties obtained for the GeC/SiC vdW heterobilayers suggest an application of the structures could boost H2fuel production via water splitting.
Numerical calculation and model experiment of a novel external buoy type wave energy converter for navigation lighted buoys numerical study of a novel wave energy converter
Authors: Huang Shuo , Liu Weiqi , Zhang Chao , Sheng Songwei , You Yage , Wang Zhenpeng , Wen Kaisheng 
Published: September 2021

AbstractA novel external buoy type wave energy device with hydraulic conversion system used for navigation lighted buoys, named floating external double buoys wave energy device, is put forward and investigated by numerical calculations and model experiments. The hydrodynamic performance of the device under regular waves is numerically calculated based on linear potential flow theory and boundary element method. The generalized modal method is used to solve the hydrodynamic problems of multi‐buoy with hinged constraints. The model experiments are carried out in a 2D wave tank with a depth of 0.9 m. The wave height is set to 1/40 of the wavelength. The influence of wave period and damping loads on the hydrodynamic performance of the device is tested. The results of numerical calculations and model experiments have shown that the appropriate selection of hydraulic damping coefficient is of great significance to improve the capture width ratio of the device, and this device has good capture performance in a certain wave range, and it is expected to effectively solve the problem of continuous power supply for middle and small types of navigation lighted buoys.
Regio- and Stereoselective Addition of Brønsted Acids to Yndiamides: Synthesis of N,O,N- and N,S,N-Trisubstituted Ketene Acetals
Authors: Anderson Edward A. , Garry Olivia L. , Mansfield Steven J. 
Published: September 2021

AbstractYndiamides, N,N-disubstituted alkynes, are versatile building blocks for the synthesis of nitrogen-containing organic molecules. Unlike ynamides, relatives that are inherently polarized by a single nitrogen substituent, their pseudo-symmetric nature renders regioselective reactions challenging. Here we report investigations into the regio­selective addition of Brønsted acids to non-symmetric yndiamides, a reaction that delivers N,O,N- and N,S,N-trisubstituted ketene acetals with excellent regio- and stereoselectivity.
Innovator Filgrastim versus Generic Filgrastim in Hematopoietic Stem Cell Transplantation Mobilization
Authors: Husian Sadik , Jeyaraman Preethi , Gupta S. K. , Rai Reeta , Pathak Sangeeta , Dayal Nitin , Naithani Rahul 
Published: September 2021

Abstract
Methods This is a retrospective study. G-CSF was administered in the dose of 10 μg/kg subcutaneous as a single dose for 4 days. On day 5, peripheral blood stem cell (PBSC) apheresis was performed using Haemonetics MCS plus or COBE Spectra apheresis machine through a double-lumen central venous catheter. Primary outcome parameters were the total number of CD34+ HSCs/kg of recipient weight mobilized in peripheral blood and the number of days required for neutrophil and platelets engraftment, respectively.
Objective We compared the effectiveness and safety of innovator filgrastim versus generic filgrastim in patients who underwent hematopoietic stem cell transplantation (HSCT).
Results A total of 91 stem cell mobilizations was analyzed. There were 58 normal healthy donors for allogeneic HSCT and 33 patients for autologous HSCT. There was no statistically significant difference among groups in terms of total collected CD34+ cells value (p = 0.609). The mean time to neutrophil engraftment was 13.7 days in the innovator group and 13.2 days in the Grafeel group (p = 0.518). The mean time to platelet engraftment was 16.2 days in the innovator group and 14.8 days in the generic group (p = 0.435). The patient who received generic filgrastim had more febrile episodes during the course of transplantation (p = 0.020).
Conclusion Generic filgrastim was found to be comparable to original filgrastim for peripheral blood stem cell mobilization in normal healthy donors for allogeneic HSCT and patients for autologous HSCT.
A Prospective Study of Taxane-Induced Neuropathy with Breast Cancer: Proper Assessment Tool for Taxane-Induced Neuropathy
Authors: Sohn Eun Hee , Lee Jin Sun , Jung Mi Sook , Kim Je Ryong 
Published: September 2021

Abstract
Background Many chemotherapeutic agents, especially taxanes, can induce peripheral neuropathy.
Aim To evaluate the clinical characteristics of taxane-induced neuropathy (TIN) and determine the proper assessment tool for TIN in patients with breast cancer.
Setting and Design Single-center, observational, prospective study.
Methods and Material Forty-three patients with breast cancer treated with taxanes were prospectively enrolled. The reduced version of the Total Neuropathy Score (TNSr) was performed at baseline and 3 months after enrollment. TIN was diagnosed if the difference between the baseline and 3-month TNSr was greater than 1. In patients with TIN, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire— Chemotherapy-Induced Peripheral Neuropathy (20-item scale (EORTC-CIPN20) was also assessed 3 months after enrollment.
Results Thirty-seven out of 43 (86.0%) patients were diagnosed with TIN. Sensory symptoms (64.9%) were the most frequent abnormality, followed by autonomic symptoms (54.1%). No patients reported motor symptoms or motor weakness. The TNSr sensory symptom score positively correlated with that of the EORTC-CIPN20. Nerve conduction studies showed reduced nerve conduction velocities and amplitudes after taxane treatment compared to those before chemotherapy in all tested nerves; however, only three (8.1%) patients had sural sensory nerve action potential amplitude outside normal limits.
Conclusions TIN was predominantly sensory with normal nerve conduction studies which is the main feature of small fiber neuropathy. A combination scale comprising of a clinician-based scale and a patient-reported questionnaire and specialized tests for small nerve fibers should be considered as proper assessment tools to evaluate TIN.
International business studies: Are we really so uniquely complex?
Authors: Aguinis Herman , Gabriel Kelly P. 
Published: September 2021

AbstractArticles in Journal of International Business Studies (JIBS) and elsewhere have argued that international business (IB) is a uniquely complex field. We offer an alternative perspective and evidence that IB is not so uniquely complex compared to organizational behavior, strategic management studies, and entrepreneurship. We argue that viewing IB as uniquely complex is likely a result of what a vast body of social psychology research has uncovered and labeled false uniqueness bias: the tendency for people to believe that they are unique compared to others. We discuss selective accessibility and focalism as underlying psychological mechanisms of this bias. We acknowledge advantages of claiming uniqueness, but argue that it is now more beneficial and realistic to highlight similarities. Doing so will allow IB to import and export theories and methods and thereby make IB borders even more permeable. In turn, increased permeability is likely to lead to further theoretical progress that will benefit IB research, practice, and its positive impact on organizations and society even further. To illustrate advantages of not exaggerating IB’s uniqueness, we use JIBS Decade Award winners as exemplars of studies that are admired and impactful precisely because of their focus on similarities rather than unique complexity.