bluuebunny/crossref_metadata_2025_split huggingface dataset:
Political Attributes of Millennials in a State University in Zambales, Philippines
Authors: Ebro Eric DS. 
Published: November 2021

The study revisited the political culture of millennials, promising citizens, and leaders of the country. It described and explored the perceptions and outlooks of millennials towards knowledge, involvement, and values as attributes of political culture. The study was a descriptive survey and correlational design. The study revealed that most millennials depend on TV and social media as sources of political information and consider integrity, honesty, intelligence, and experience to vote for a candidate in an election. Meanwhile, there is a significant difference among the three political attributes as shown in the computed F-value of 56.94; millennials have the highest level of attributes in political values compared with political knowledge and involvement. Interestingly, the result indicates no significant difference between the male and female levels of political attributes. On the other hand, the computed F-value of 3.05 showed an apparent significant difference in political attributes of millennials when grouped according to religion. Generally, millennials have a high level of political attributes; this indicated that despite that millennials were in the midst of the fast-changing world brought by media and technology, they stay active citizens as seen in their political values that remain highly intact.
Endothelial Yin Yang 1 Phosphorylation at S118 Induces Atherosclerosis Under Flow
Authors: Wei Shu-Yi , Shih Yu-Tsung , Wu Hsin-Yi , Wang Wei-Li , Lee Pei-Ling , Lee Chih-I , Lin Chia-Yu , Chen Yu-Ju , Chien Shu , Chiu Jeng-Jiann 
Published: November 2021

Rationale:
Disturbed flow occurring in arterial branches and curvatures induces vascular endothelial cell (EC) dysfunction and atherosclerosis. We postulated that disturbed flow plays important role in modulating phosphoprotein expression profiles to regulate endothelial functions and atherogenesis.

Objective:
The goal of this study is to discover novel site-specific phosphorylation alterations induced by disturbed flow in ECs to contribute to atherosclerosis.

Methods and Results:

Quantitative phosphoproteomics analysis of ECs exposed to disturbed flow with low and oscillatory shear stress (0.5±4 dynes/cm
2
) versus pulsatile shear stress (12±4 dynes/cm
2
) revealed that oscillatory shear stress induces phospho-YY1
S118
(serine [S]118 phosphorylation of Yin Yang 1) in ECs. Elevated phospho-YY1
S118
level in ECs was further confirmed to be present in the disturbed flow regions in experimental animals and human atherosclerotic arteries. This disturbed flow-induced EC phospho-YY1
S118
is mediated by CK2α (casein kinase 2α) through its direct interaction with YY1. Yeast 2-hybrid library screening and in situ proximity ligation assays demonstrate that phospho-YY1
S118
directly binds ZKSCAN4 (zinc finger with KRAB [krüppel-associated box] and SCAN [SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA] domains 4) to induce promoter activity and gene expression of HDM2 (human double minute 2), which consequently induces EC proliferation through downregulation of p53 and p21
CIP1
. Administration of apoE-deficient (

ApoE
−/−

) mice with CK2-specific inhibitor tetrabromocinnamic acid or atorvastatin inhibits atherosclerosis formation through downregulations of EC phospho-YY1
S118
and HDM2. Generation of novel transgenic mice bearing EC-specific overexpression of S118-nonphosphorylatable mutant of YY1 in

ApoE
−/−

mice confirms the critical role of phospho-YY1
S118
in promoting atherosclerosis through EC HDM2.

Conclusions:

Our findings provide new insights into the mechanisms by which disturbed flow induces endothelial phospho-YY1
S118
to promote atherosclerosis, thus indicating phospho-YY1
S118
as a potential molecular target for atherosclerosis treatment.
Serial Assessment of High-Sensitivity Cardiac Troponin and the Effect of Dapagliflozin in Patients With Heart Failure With Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial
Authors: Berg David D. , Docherty Kieran F. , Sattar Naveed , Jarolim Petr , Welsh Paul , Jhund Pardeep S. , Anand Inder S. , Chopra Vijay , de Boer Rudolf A. , Kosiborod Mikhail N. , Nicolau Jose C. , O’Meara Eileen , Schou Morten , Hammarstedt Ann , Langkilde Anna-Maria , Lindholm Daniel , Sjöstrand Mikaela , McMurray John J.V. , Sabatine Marc S. , Morrow David A. 
Published: November 2021

Background:
Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure and death in patients with heart failure with reduced ejection fraction. Less is known about the prognostic significance of changes in hsTnT over time, the effects of dapagliflozin on clinical outcomes in relation to baseline hsTnT levels, and the effect of dapagliflozin on hsTnT levels.

Methods:
DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) was a randomized, double-blind, placebo-controlled trial of dapagliflozin (10 mg daily) in patients with New York Heart Association class II to IV symptoms and left ventricular ejection fraction ≤40% (median follow-up, 18.2 months). hsTnT (Roche Diagnostics) was measured at baseline in 3112 patients and at 1 year in 2506 patients. The primary end point was adjudicated worsening heart failure or cardiovascular death. Clinical end points were analyzed according to baseline hsTnT and change in hsTnT from baseline to 1 year. Comparative treatment effects on clinical end points with dapagliflozin versus placebo were assessed by baseline hsTnT. The effect of dapagliflozin on hsTnT was explored.

Results:
Median baseline hsTnT concentration was 20.0 (25th–75th percentile, 13.7–30.2) ng/L.

Over 1 year, 67.9% of patients had a ≥10% relative increase or decrease in hsTnT concentrations, and 43.5% had a ≥20% relative change. A stepwise gradient of higher risk for the primary end point was observed across increasing quartiles of baseline hsTnT concentration (adjusted hazard ratio Q4 versus Q1, 3.44 [95% CI, 2.46–4.82]). Relative and absolute increases in hsTnT over 1 year were associated with higher subsequent risk of the primary end point. The relative reduction in the primary end point with dapagliflozin was consistent across quartiles of baseline hsTnT (
P
-interaction=0.55), but patients in the top quartile tended to have the greatest absolute risk reduction (absolute risk difference, 7.5% [95% CI, 1.0%–14.0%]). Dapagliflozin tended to attenuate the increase in hsTnT over time compared with placebo (relative least squares mean reduction, –3% [–6% to 0%];
P
=0.076).

Conclusions:
Higher baseline hsTnT and greater increase in hsTnT over 1 year are associated with worse clinical outcomes. Dapagliflozin consistently reduced the risk of the primary end point, irrespective of baseline hsTnT levels.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03036124.
The data set knowledge graph: Creating a linked open data source for data sets
Authors: Färber Michael , Lamprecht David 
Published: November 2021

Abstract
Several scholarly knowledge graphs have been proposed to model and analyze the academic landscape. However, although the number of data sets has increased remarkably in recent years, these knowledge graphs do not primarily focus on data sets but rather on associated entities such as publications. Moreover, publicly available data set knowledge graphs do not systematically contain links to the publications in which the data sets are mentioned. In this paper, we present an approach for constructing an RDF knowledge graph that fulfills these mentioned criteria. Our data set knowledge graph, DSKG, is publicly available at http://dskg.org and contains metadata of data sets for all scientific disciplines. To ensure high data quality of the DSKG, we first identify suitable raw data set collections for creating the DSKG. We then establish links between the data sets and publications modeled in the Microsoft Academic Knowledge Graph that mention these data sets. As the author names of data sets can be ambiguous, we develop and evaluate a method for author name disambiguation and enrich the knowledge graph with links to ORCID. Overall, our knowledge graph contains more than 2,000 data sets with associated properties, as well as 814,000 links to 635,000 scientific publications. It can be used for a variety of scenarios, facilitating advanced data set search systems and new ways of measuring and awarding the provisioning of data sets.
Mapping and impact assessment of phenomenon-oriented research fields: The example of migration research
Authors: Rothenberger Liane , Pasta Muhammad Qasim , Mayerhoffer Daniel 
Published: November 2021

Abstract
Research that is not explicitly bound to a distinct discipline has not yet gained much acknowledgment with regard to research impact assessment and mapping of the respective research field. In this article, we provide a suggestion for new impact metrics taking the example of migration research as a phenomenon-oriented research field. Therewith, research merit is made comparable and is calculated irrespective of discipline. We show how the field of migration studies evolved, apply our new metrics and give insight into impact factors, numbers of citations of articles, and authors, as well as journals. Further, we present a field-related collaboration network that indicates a rather disconnected community. However, collaborations between researchers are on the rise. In our conclusion, we argue that there is a need for further assessment of research impact within other phenomenon-oriented research fields.
Covid-on-the-Web: Exploring the COVID-19 scientific literature through visualization of linked data from entity and argument mining
Authors: Menin Aline , Michel Franck , Gandon Fabien , Gazzotti Raphaël , Cabrio Elena , Corby Olivier , Giboin Alain , Marro Santiago , Mayer Tobias , Villata Serena , Winckler Marco 
Published: November 2021

Abstract
The unprecedented mobilization of scientists caused by the COVID-19 pandemic has generated an enormous number of scholarly articles that are impossible for a human being to keep track of and explore without appropriate tool support. In this context, we created the Covid-on-the-Web project, which aims to assist the accessing, querying, and sense-making of COVID-19-related literature by combining efforts from the semantic web, natural language processing, and visualization fields. In particular, in this paper we present an RDF data set (a linked version of the “COVID-19 Open Research Dataset” (CORD-19), enriched via entity linking and argument mining) and the “Linked Data Visualizer” (LDViz), which assists the querying and visual exploration of the referred data set. The LDViz tool assists in the exploration of different views of the data by combining a querying management interface, which enables the definition of meaningful subsets of data through SPARQL queries, and a visualization interface based on a set of six visualization techniques integrated in a chained visualization concept, which also supports the tracking of provenance information. We demonstrate the potential of our approach to assist biomedical researchers in solving domain-related tasks, as well as to perform exploratory analyses through use case scenarios.
West German Rearmament Protests and the Reframing of Germany as Pacifist
Authors: Whitworth William 
Published: November 2021

Abstract
This paper tracks the reactions of British and U.S. officials to a wave of anti-rearmament protests in West Germany in the early 1950s. The conversations that these protests encouraged were significant in that they represented the beginning of a gradual change in the reputation of the German people – whereas in 1945 the Germans were widely considered a militaristic and aggressive people, by the end of the Cold War they were seen as largely pacifist. This change speaks to the power of social movements to drive new trends in international relations.
Interdecadal Changes in the Relationship between Wintertime Surface Air Temperature over the Indo-China Peninsula and ENSO
Authors: Li Juncong , Wen Zhiping , Li Xiuzhen , Guo Yuanyuan 
Published: November 2021

Abstract
Interdecadal variations of the relationship between El Niño–Southern Oscillation (ENSO) and the Indo-China Peninsula (ICP) surface air temperature (SAT) in winter are investigated in the study. Generally, there exists a positive correlation between them during 1958–2015 because the ENSO-induced anomalous western North Pacific anticyclone (WNPAC) is conducive to pronounced temperature advection anomalies over the ICP. However, such correlation is unstable in time, having experienced a high-to-low transition around the mid-1970s and a recovery since the early 1990s. This oscillating relationship is owing to the anomalous WNPAC intensity in different decades. During the epoch of high correlation, the anomalous WNPAC and associated southwesterly winds over the ICP are stronger, which brings amounts of warm temperature advection and markedly heats the ICP. In contrast, a weaker WNPAC anomaly and insignificant ICP SAT anomalies are the circumstances for the epoch of low correlation. It is also found that substantial southwesterly wind anomalies over the ICP related to the anomalous WNPAC occur only when large sea surface temperature (SST) anomalies over the northwest Indian Ocean (NWIO) coincide with ENSO (viz., when the ENSO–NWIO SST connection is strong). The NWIO SST anomalies are capable of driving favorable atmospheric circulation that effectively alters ICP SAT and efficiently modulates the ENSO–ICP SAT correlation, which is further supported by numerical simulations utilizing the Community Atmospheric Model, version 4 (CAM4). This paper emphasizes the non-stationarity of the ENSO–ICP SAT relationship and also uncovers the underlying modulation factors, which has important implications for the seasonal prediction of the ICP temperature.
The Role of the US Trauma Centers in Older Adult Fall Prevention: A National Survey
Authors: Allee Lisa , Faul Mark , Guntipalli Prathima , Burke Peter A. , Rao Sowmya R. , Reed Donald N. , Gross Ronald , Duncan Thomas K. , Palmieri Tina L. , Cooper Zara , Bulger Eileen M. , Stewart Ronald M. , Kuhls Deborah A. 
Published: November 2021

Introduction Approximately 27.5% of adults 65 and older fall each year, over 3 million are treated in an emergency department, and 32 000 die. The American College of Surgeons and its Committee on Trauma (ACSCOT) have urged trauma centers (TCs) to screen for fall risk, but information on the role of TC in this opportunity for prevention is largely unknown. Methods A 29-item survey was developed by an ACSCOT Injury Prevention and Control Committee, Older Adult Falls workgroup, and emailed to 1000 trauma directors of the National Trauma Data Bank using Qualtrics. US TCs were surveyed regarding fall prevention, screening, intervention, and hospital discharge practices. Data collected and analyzed included respondent’s role, location, population density, state designation or American College of Surgeons (ACS) level, if teaching facility, and patient population. Results Of the 266 (27%) respondents, 71% of TCs include fall prevention as part of their mission, but only 16% of TCs use fall risk screening tools. There was no significant difference between geographic location or ACS level. The number of prevention resources (F = 31.58, P < .0001) followed by the presence of a formal screening tool (F = 21.47, P < .0001) best predicted the presence of a fall prevention program. Conclusion Older adult falls remain a major injury risk and injury prevention opportunity. The majority of TCs surveyed include prevention of older adult falls as part of their mission, but few incorporate the components of a fall prevention program. Development of best practices and requiring TCs to screen and offer interventions may prevent falls.
Effect of COVID-19 Pandemic Restructuring on Surgical Volume and Outcomes of Non-COVID Patients Undergoing Surgery
Authors: Shao Connie C. , McLeod M Chandler , Gleason Lauren , Marques Isabel C. Dos Santos , Chu Daniel I. , Gunnells Drew 
Published: November 2021

Objectives COVID-19 has caused significant surgical delays as institutions minimize patient exposure to hospital settings and utilization of health care resources. We aimed to assess changes in surgical case mix and outcomes due to restructuring during the pandemic. Methods Patients undergoing surgery at a single tertiary care institution in the Deep South were identified using institutional ACS-NSQIP data. Primary outcome was case mix. Secondary outcomes were post-operative complications. Chi-square, ANOVA, logistic regression, and linear regression were used to compare the control (pre-COVID, Mar 2018-Mar 2020) and case (during COVID, Mar 2020-Mar 2021) groups. Results Overall, there were 6912 patients (control: 4,800 and case: 2112). Patients were 70% white, 29% black, 60% female, and 39% privately insured. Mean BMI was 30.2 (SD = 7.7) with mean age of 58.3 years (SD = 14.8). Most surgeries were with general surgery (48%), inpatient (68%), and elective (83%). On multivariable logistic regression, patients undergoing surgery during the pandemic were more likely to be male (OR: 1.14) and in SIRS (OR: 2.07) or sepsis (OR: 2.28) at the time of surgery. Patients were less likely to have dyspnea with moderate exertion (OR: .75) and were less dependent on others (partially dependent OR: .49 and totally dependent OR: .15). Surgeries were more likely to be outpatient (OR: 1.15) and with neurosurgery (OR: 1.19). On bivariate analysis, there were no differences in post-operative outcomes. Conclusion Surgeries during the COVID-19 pandemic were more often outpatient without differences in post-operative outcomes. Additional analysis is needed to determine the impact of duration of operative delay on surgical outcomes with restructuring focusing more on outpatient surgeries.
Correlating Toe-Brachial Indices and Angiographically Confirmed Peripheral Artery Disease: A Retrospective Review
Authors: Baloch Zulfiqar Qutrio , Abbas Shabber Agha , Prasad Rohan , Raza Syed Ali , Al-Abcha Abdullah , Marone Luke , Ali Abbas 
Published: November 2021

In advanced peripheral arterial disease (PAD), medial arterial calcification is known to inflate the ankle-brachial index. An alternative method of evaluating symptomatic patients is toe-brachial indexes (TBI), where a ratio less than .7 indicates PAD and less than .4 indicates a severe form. The objective of this retrospective analysis was to investigate the association between TBIs less than .7 and angiographically verified PAD. Patients were required to have either a leg angiogram 13 months prior to or 12 months after a 6-minute walk test. Of the 174 included patients, the mean overall TBI was .450. The mean TBI by location was highest at iliac and infra-geniculate with .544 and lowest at supra-geniculate with .372. Infra-geniculate lesions were also the most frequent ( n = 46). A TBI less than .4 was found in 47.7% of patients. TBIs greater than .7 were present in 36 patients; however, only 16 had significant angiographic stenosis. In conclusion, the majority of patients with angiographic PAD had a TBI less than .7, especially less than .4. Contrary to suspicion, infra-geniculate lesions were the most common and had the highest TBI.
Association between single-slice and whole heart measurements of epicardial and pericardial fat in cardiac MRI
Authors: Vach Marius , Luetkens Julian A , Faron Anton , Isaak Alexander , Salam Babak , Thomas Daniel , Attenberger Ulrike I , Sprinkart Alois M 
Published: November 2021

Background Epicardial (ECF) and pericardial fat (PCF) are important prognostic markers for various cardiac diseases. However, volumetry of the fat compartments is time-consuming. Purpose To investigate whether total volume of ECF and PCF can be estimated by axial single-slice measurements and in a four-chamber view. Material and Methods A total of 113 individuals (79 patients and 34 healthy) were included in this retrospective magnetic resonance imaging (MRI) study. The total volume of ECF and PCF was determined using a 3D-Dixon sequence. Additionally, the area of ECF and PCF was obtained in single axial layers at five anatomical landmarks (left coronary artery, right coronary artery, right pulmonary artery, mitral valve, coronary sinus) of the Dixon sequence and in a four-chamber view of a standard cine sequence. Pearson's correlation coefficient was calculated between the total volume and each single-slice measurement. Results Axial single-slice measurements of ECF and PCF correlated strongly with the total fat volumes at all landmarks (ECF: r  =  0.85–0.94, P < 0.001; PCF: r  =  0.89–0.94, P < 0.001). The best correlation was found at the level of the left coronary artery for ECF and PCF ( r  =  0.94, P < 0.001). Correlation between single-slice measurement in the four-chamber view and the total ECF and PCF volume was lower ( r  =  0.75 and r  =  0.8, respectively, P < 0.001). Conclusion Single-slice measurements allow an estimation of ECF and PCF volume. This time-efficient analysis allows studies of larger patient cohorts and the opportunistic determination of ECF/PCF from routine examinations.
Artesunate attenuates inflammatory injury and inhibits the NF-κB pathway in a mouse model of cerebral ischemia
Authors: Liu Ying , Dang Wei , Zhang Shiyang , Wang Lina , Zhang Xiangjian 
Published: November 2021

Objective Inflammation is an important factor in the pathological process of cerebral ischemia. Artesunate exhibits a broad range of anti-inflammatory properties in many diseases. We investigated the potential protective effect of artesunate against cerebral ischemia and the related mechanisms. Methods Mice were divided into distal middle cerebral artery occlusion (dMCAO), sham, low dose, and high dose groups and subjected to dMCAO, except for the sham group. The low and high dose groups were administered artesunate (15 and 30 mg/kg), and the neuroprotective effects were analyzed by evaluating infarct volumes and neurological deficits. Microglial activation and neutrophil infiltration were evaluated by immunofluorescence, immunohistochemical staining, and western blotting. Inflammatory mediators were measured by enzyme-linked immunosorbent assays. Nuclear factor (NF)-κB nuclear translocation was detected by immunofluorescence and western blotting. Results Compared with the dMCAO group, artesunate significantly improved neurological deficit scores and infarct volumes and ameliorated inflammation by reducing neutrophil infiltration, suppressing microglial activation, and downregulating tumor necrosis factor-α and interleukin-1β expression. Furthermore, artesunate inhibited nuclear translocation of NF-κB and inhibitor protein α proteolysis. Conclusions Artesunate protected against inflammatory injury by reducing neutrophil infiltration and microglial activation, suppressing inflammatory cytokines, and inhibiting the NF-κB pathway. Therefore, artesunate is a potential ischemic stroke treatment.