bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wrist–ankle acupuncture attenuates cancer-induced bone pain by regulating descending pain-modulating system in a rat model
Authors: Zhang Chunpeng , Xia Chen , Zhang Xiaowen , Li Weimin , Miao Xuerong , Zhou Qinghui 
Published: February 2021

AbstractBackgroundCancer-induced bone pain (CIBP) presents a multiple-mechanism of chronic pain involving both inflammatory and neuropathic pain, and its pathogenesis is closely related to endogenous descending system of pain control. However, the action mechanism underlying the effects of wrist–ankle acupuncture (WAA) versus electroacupuncture (EA) on CIBP remains unknown.MethodsThirty-two Wistar rats were divided into sham, CIBP, EA-treated and WAA-treated groups. CIBP was induced in rats of the latter three groups. Time courses of weight and mechanical hyperalgesia threshold (MHT) were evaluated. After 6 days of EA or WAA treatment, the expressions of 5-hydroxytryotamine type 3A receptor (5-HT3AR) andμ-opioid receptor (MOR) in rostral ventromedial medulla (RVM) and/or spinal cord, as well as the levels of 5-HT, β-endorphin, endomorphin-1 and endomorphin-2 in RVM and spinal cord, were detected.ResultsInjection of cancer cells caused decreased MHT, which was attenuated by EA or WAA (P < 0.05). WAA had a quicker analgesic effect than EA (P < 0.05). No significant difference of MOR in RVM was found among the four groups. EA or WAA counteracted the cancer-driven upregulation of 5-HT3AR and downregulation of MOR in spinal cord (P < 0.05), and upregulation of 5-HT and downregulation of endomorphin-1 in both RVM and spinal cord (P < 0.05). β-endorphin and endomorphin-2 in RVM and spinal cord decreased in CIBP group compared with sham group (P < 0.05), but EA or WAA showed no significant effect on them, although a tendency of increasing effect was observed.ConclusionWAA, similar to EA, alleviated mechanical hyperalgesia in CIBP rats by suppressing the expressions of 5-HT and 5-HT3AR, and increasing the expressions of MOR and endomorphin-1 in RVM-spinal cord pathway of the descending pain-modulating system. However, WAA produced a quicker analgesic effect than EA, the mechanisms of which need further investigation.
Determinants of economic achievement for women entrepreneurs in Ethiopia
Authors: Beriso Beshir Shaku 
Published: February 2021

AbstractThe main objective of this paper is to assess the determinants and challenges of economic achievement for women entrepreneurs in Ethiopia. The study used 698 sample women entrepreneurs selected randomly from a total of 2450 respondents. The data were analyzed using descriptive statistics and multiple linear regression models. The results revealed that there is a high rate of challenges for divorced (30%) and widowed (41%) women entrepreneurs in the selected area. The results of multiple linear regression show that the educational level, family size, region (SNNP, Gambella, Harari, Dire Dawa, and Addis Ababa), parents’ educational level, number of financially dependent people, business experiences, and access to raw materials were positive predictors of the income of women entrepreneurs. It is also found that entrepreneurial area (Afar, Amhara, and Oromiya), marital status (divorced and widowed), entrepreneurship training, enterprise’s license, and lack of supporting institutions were negatively related with the income of women entrepreneurs. Therefore, improving entrepreneurs’ and parents’ education, providing entrepreneurship training, sharing business experiences, supporting entrepreneurs is the main instrumental in minimizing the factors affecting the income of women entrepreneurs. Moreover, it is advisable if the business participation status of women be assessed periodically to monitor the situation and to take appropriate measures for combating and preventing the challenges facing women entrepreneurs in economic growth.
Effects of full replacement of dietary fishmeal with insect meal from Tenebrio molitor on rainbow trout gut and skin microbiota
Authors: Terova Genciana , Gini Elisabetta , Gasco Laura , Moroni Federico , Antonini Micaela , Rimoldi Simona 
Published: February 2021

Abstract
Background
Aquaculture must continue to reduce dependence on fishmeal (FM) and fishoil in feeds to ensure sustainable sector growth. Therefore, the use of novel aquaculture feed ingredients is growing. In this regard, insects can represent a new world of sustainable and protein-rich ingredients for farmed fish feeds. Accordingly, we investigated the effects of full replacement of FM with Tenebrio molitor (TM) larvae meal in the diet of rainbow trout (Oncorhynchus mykiss) on fish gut and skin microbiota.

Methods
A feeding trial was conducted with 126 trout of about 80 g mean initial weight that were fed for 22 weeks with two isonitrogenous, isolipidic, and isoenergetic extruded experimental diets. Partially defatted TM meal was included in one of the diets to replace 100% (TM 100) of FM, whereas the other diet (TM 0) was without TM. To analyse the microbial communities, the Illumina MiSeq platform for sequencing of 16S rRNA gene and Qiime pipeline were used to identify bacteria in the gut and skin mucosa, and in the diets.

Results
The data showed no major effects of full FM substitution with TM meal on bacterial species richness and diversity in both, gut mucosa- and skin mucus-associated microbiome. Skin microbiome was dominated by phylum Proteobacteria and especially by Gammaproteobacteria class that constituted approximately half of the bacterial taxa found. The two dietary fish groups did not display distinctive features, except for a decrease in the relative abundance of Deefgea genus (family Neisseriaceae) in trout fed with insect meal. The metagenomic analysis of the gut mucosa indicated that Tenericutes was the most abundant phylum, regardless of the diet. Specifically, within this phylum, the Mollicutes, mainly represented by Mycoplasmataceae family, were the dominant class. However, we observed only a weak dietary modulation of intestinal bacterial communities. The only changes due to full FM replacement with TM meal were a decreased number of Proteobacteria and a reduced number of taxa assigned to Ruminococcaceae and Neisseriaceae families.

Conclusions
The data demonstrated that TM larvae meal is a valid alternative animal protein to replace FM in the aquafeeds. Only slight gut and skin microbiota changes occurred in rainbow trout after total FM replacement with insect meal. The mapping of the trout skin microbiota represents a novel contribution of the present study. Indeed, in contrast to the increasing knowledge on gut microbiota, the skin microbiota of major farmed fish species remains largely unmapped but it deserves thorough consideration.
Prospective K-8 teachers’ noticing of student justifications and generalizations in the context of analyzing written artifacts and video-records
Authors: Magiera Marta T. , Zambak Vecihi S. 
Published: February 2021

Abstract
Background
This paper contributes to current discussions about supporting prospective teachers (PSTs) in developing skills of noticing students’ mathematical thinking. We draw attention to PSTs’ initial noticing skills (prior to instruction focused on supporting noticing) as PSTs engage in analyzing written artifacts of student work and video-records. We examined and compared PSTs’ noticing skills as they analyzed how students reason about, generalize, and justify generalizations of figural patterns given student written work and video records. We identified aspects of student thinking about generalizations and justifications, which PSTs addressed and interpreted. We also examined how PSTs respond to students as they analyze student thinking given written artifacts of student work or video-records of small group discussions, and we identified the foci of PSTs’ responding practice.

Results
Our data revealed that PSTs’ initial noticing skills of student generalizations and justifications differed while accounting for ways in which student thinking was externalized (written work or video-records). PSTs’ attending-and-interpreting and their responding practices were focused on mathematically significant aspects of student thinking to a greater extent in the context of analyzing written artifacts compared to video records. While analyzing students’ written work, PSTs demonstrated greater attention to ways in which students analyzed patterns, students’ generalization strategies, and justifications linked to an understanding of the pattern structure, compared to analyzing student thinking captured via videos.

Conclusion
Our results document that without providing any intentional support for PSTs’ noticing skills, PSTs are more deliberate to focus on mathematically significant aspects of student thinking while analyzing written artifacts of student work compared to video-records. We believe that the analysis of student written work might demand from PSTs to be more analytical. While examining written representations, PSTs have to reconstruct students’ reasoning. Unlike the videos where the students tell or use gestures to express their thinking, written work provides fewer clues about student thinking. Thus, written work demands a deeper level of engagement from PSTs as they strive to understand student reasoning. Our study extends research on PSTs’ noticing skills by documenting differences in PSTs’ noticing in relation to the nature of artifacts of student work that PSTs analyze. Our work also adds to prior research on PSTs’ noticing by characterizing specific aspects of students’ thinking about pattern generalizations and justifications that PSTs address as they analyze student thinking and respond to students.
Specific techniques for right sleeve lower lobectomy: four case reports
Authors: Hamasaki Hirokazu , Shirakami Chika , Yamada Tatsuya , Motooka Yamato , Fujino Kosuke , Ikeda Koei , Suzuki Makoto 
Published: February 2021

Abstract
Background
Right sleeve lower lobectomy is rarely performed because pulmonary function of the middle lobe is not spared to the extent of the other lobes and achieving a proper bronchial anastomosis is technically more difficult than other sleeve lobectomies.

Case presentation
We performed four right sleeve lower lobectomies and had good clinical outcomes using specific technical options, such as telescope anastomosing, pericardiotomy, interlobar dissection between the upper and middle lobes, and angioplasty of the lower pulmonary artery, if needed.

Conclusions
The cases presented herein demonstrated that a right sleeve lower lobectomy is one option by which to preserve the middle lobe using specific techniques and is thus recommended in select patients.
Long-term survival after pancreatic metastasis resection from breast cancer: a systematic literature review
Authors: Nagao Atsuki , Noie Tamaki , Horiuch Hajime , Yamada Haruyasu , Momiyama Masashi , Nakajima Kentaro , Satou Shouichi , Satodate Hitoshi , Nara Satoshi , Harihara Yasushi 
Published: February 2021

Abstract
Background
Patients with advanced-stage breast cancer often demonstrate pancreatic metastases. However, pancreatic metastases resection from breast cancer has been rarely performed, with only 20 cases having been reported to date.

Case presentation
A 49-year-old woman presented to our hospital in September 2003 with complaints of uncontrollable oozing from her left breast tumor. Computed tomography revealed a left breast tumor approximately 9.3 cm in diameter as well as heterogeneously enhanced solid mass lesions with necrotic foci in the pancreatic tail and body, up to 6.2 cm, which were radiologically diagnosed as pancreatic metastases from breast cancer. An emergent left simple mastectomy was performed to control bleeding. After epirubicin and cyclophosphamide hydrate treatment failed to improve her condition, the pancreatic metastases responded to weekly paclitaxel treatment, but eventually regrew. The patient underwent distal pancreatectomy with splenectomy, left adrenalectomy, partial stomach resection, and paraaortic lymph nodes excision in December 2004 after no other metastasis was confirmed. Furthermore, she received radiation therapy for left parasternal lymph node metastasis 6 months later. The patient recovered well. Consequently, she has no evidence of disease > 15 years after pancreatectomy.

Conclusions
This is the first reported case of pancreatectomy for pancreatic metastases from breast cancer, which was simultaneously diagnosed. Patients with no metastasis other than resectable pancreatic metastases and breast cancer and who possess some sensitivity for chemotherapy may benefit from pancreatectomy.
A simple and affordable method for estimating the fluid volume a mosquito sucks using food dyes
Authors: Sakuma Chisako , Kanuka Hirotaka 
Published: February 2021

Abstract
Background
Blood-sucking by mosquitoes is an inevitable behavior when pathogens are transmitted among humans. Adenine nucleotides such as ATP are known as phagostimulants for mosquitoes and are widely used to induce and enhance the blood-sucking activity in an artificial manner. Although using ATP solution is convenient to introduce a variety of substances (for example chemicals and pathogens) into the mosquito body via sucking, establishing an easy and cost-effective method to quantify the amount of solution ingested has yet to be reported.

Results
A set of commercial food dyes (green, blue, yellow, and red) was employed in this study. Each dye was added to ATP solution used to colorize the abdomen of Ae. aegypti female mosquitoes after ingestion. The intake of food dyes did not show any toxicity to the mosquitoes, affecting neither ATP-sucking behavior nor survival of the mosquitoes. We observed that quantifying the color intensity of green dye in the mosquito abdomen by spectral analysis, as well as distinguishing the size of the colored abdomen using the naked eye, allowed the estimation of the amount of ingested solution. Using this method, capsaicin, a pungent component of chili peppers, was identified as an aversive tastant that can discourage mosquitoes from sucking the ATP solution.

Conclusions
Employing commercially available, non-toxic food dyes converted ATP-driven membrane feeding into an easy-to-use method to estimate the amount of solution ingested by mosquitoes. This method can be further applied for a variety of experiments such as introducing a certain quantity of chemical compounds or microbes into the mosquito body.
Advanced compositional imaging T2 mapping sequence in detection of stages of medial knee joint compartments articular cartilage degeneration
Authors: El-Liethy Nevien Ezzat , Kamal Heba Ahmed 
Published: February 2021

Abstract
Background
The predictive value of the new imaging sequences, especially T2 mapping in assessment of articular cartilage abnormalities of the medial knee compartments in patients with medial knee pain. The purpose of this study is to evaluate the additional value of T2 mapping over using a baseline standard knee MRI to detect cartilage lesions of the medial compartments in patients representing with medial knee pain.

Results
The study included 60 patients presented with medial knee pain, where divided into two groups ; control group (20 volunteers) with age range from 19 to 41 years old 26.80 ± 8.05 (mean ± SD) and patients (40 candidates) with age range from 13 to 57 years old with a mean age 33.00 ± 14.1 (mean ± SD).

Conclusion
On adding T2 mapping sequence to the routine MRI of the knee, the sensitivity for detecting knee cartilage lesions was increased, especially in the detection of early cartilage degeneration at the medial compartment.
Compositional MR imaging including T2 mapping plays an important role in the assessment of early and potentially reversible cartilage damage especially among the young population.
Relapse and frequency of injection of monthly paliperidone palmitate—A retrospective case–control study
Authors: Laing Emily , Taylor David 
Published: February 2021

Abstract

Background
Outcomes with long-acting injections (LAIs) are generally better than with oral antipsychotic therapy. However, the use of LAIs does not assure compliance with treatment and in clinical practice patients often miss injections or receive their injections later than intended.

Method
We conducted a case–control study to identify demographic and treatment associations with relapse (cases) on paliperidone 1-monthly injection (PP1M) compared with age-, gender-, and ethnicity-matched controls.

Results
We identified 16 cases and matched 43 controls. Baseline variables did not differ except that cases had received significantly more antipsychotic drugs before initiation with PP1M (3.94 vs. 2.12; p < 0.001). Cases had fewer PP1M injections administered compared with the control group (9.69 vs. 11.37; p < 0.001) and this group had a longer interval between injections than the control group (37 vs. 33 days; p < 0.001).

Conclusions
Relapse on PP1M is associated with reduced frequency of injection and a longer interval between doses.
Racial, Ethnic, and Socioeconomic Discrepancies in Opioid Prescriptions Among Older Patients With Cancer
Authors: Vitzthum Lucas K. , Nalawade Vinit , Riviere Paul , Sumner Whitney , Nelson Tyler , Mell Loren K. , Furnish Timothy , Rose Brent , Martínez María Elena , Murphy James D. 
Published: February 2021

PURPOSE: Minority race and lower socioeconomic status are associated with lower rates of opioid prescription and undertreatment of pain in multiple noncancer healthcare settings. It is not known whether these differences in opioid prescribing exist among patients undergoing cancer treatment. METHODS AND MATERIALS: This observational cohort study involved 33,872 opioid-naive patients of age > 65 years undergoing definitive cancer treatment. We compared rates of new opioid prescriptions by race or ethnicity and socioeconomic status controlling for differences in baseline patient, cancer, and treatment factors. To evaluate downstream impacts of opioid prescribing and pain management, we also compared rates of persistent opioid use and pain-related emergency department (ED) visits. RESULTS: Compared with non-Hispanic White patients, the covariate-adjusted odds of receiving an opioid prescription were 24.9% (95% CI, 16.0 to 33.9, P < .001) lower for non-Hispanic Blacks, 115.0% (84.7 to 150.3, P < .001) higher for Asian–Pacific Islanders, and not statistically different for Hispanics (−1.0 to 14.0, P = .06). There was no significant association between race or ethnicity and persistent opioid use or pain-related ED visits. Patients living in a high-poverty area had higher odds (53.9% [25.4 to 88.8, P < .001]) of developing persistent use and having a pain-related ED visit (39.4% [16.4 to 66.9, P < .001]). CONCLUSION: For older patients with cancer, rates of opioid prescriptions and pain-related outcomes significantly differed by race and area-level poverty. Non-Hispanic Black patients were associated with a significantly decreased likelihood of receiving an opioid prescription. Patients from high-poverty areas were more likely to develop persistent opioid use and have a pain-related ED visit.
Maternal Oxidative Stress Biomarkers in Pregnancy and Child Growth from Birth to Age 6
Authors: Arogbokun Olufunmilayo , Rosen Emma , Keil Alexander P , Milne Ginger L , Barrett Emily , Nguyen Ruby , Bush Nicole R , Swan Shanna H , Sathyanarayana Sheela , Ferguson Kelly K 
Published: February 2021

Abstract

Context
Maternal oxidative stress in pregnancy can arise through a multitude of sources and may have lifelong consequences for the child. Animal studies suggest that prenatal oxidative stress may contribute to metabolic dysfunction and excessive weight gain in the offspring. However, this relationship has been studied minimally in humans.

Objective
Determine the association between prenatal oxidative stress biomarkers and child weight and body mass index (BMI) z-scores from birth to age 6.

Methods
Within The Infant Development and the Environment Study (TIDES) prospective pregnancy cohort, we calculated age- and sex-specific Z-scores for child weight and BMI, measured between birth and age 6 (N = 736). Three oxidative stress biomarkers were quantified in third-trimester urine, including 8-iso-prostaglandin F2α (8-iso-PGF2α), its primary metabolite, and prostaglandin F2α (PGF2α). We examined associations between each biomarker and Z-scores using linear regression as well as group-based trajectory modeling.

Results
Prenatal 8-iso-PGF2α and its metabolite were associated with lower birth weight and higher weight at age 4. For example, an ln-unit increase in 8-iso-PGF2α was associated with 0.17 SD higher weight at age 4 (95% CI 0.01, 0.33). These biomarkers were also associated with higher BMI at age 4. Finally, within 4 unique weight trajectories (low, normal, high, and low–high), children of mothers with higher 8-iso-PGF2α were 2.56 times more likely (95% CI 1.22, 5.41) to be in the low–high trajectory than children in the normal group.

Conclusion
We observed associations between third-trimester oxidative stress and lower birth weight as well as higher early childhood weight and BMI. These findings have important implications for understanding the developmental origins of childhood weight gain and metabolic disease.
Unhatching the Egg in Lebanon’s 2019 Protests
Authors: Kosmatopoulos Nikolas 
Published: February 2021

This auto-ethnographic essay revisits the story of the Beirut City Center Dome, also known as the “Egg,” a 1960s brutalist-modernist cinema abandoned to snipers during Lebanon’s civil war, which briefly became a stage for a direct action politics in the early days of Lebanon’s October 2019 uprising. One of the uprising’s most ambitious aims was the ushering in of a new social contract beyond sectarian divisions.
The essay tests the argument that a postwar model of expert-driven peace, which involves compartmentalizing the political society while devolving power into real-estate investors–prime ministers, crucially depends on the constant reproduction of technomoral hierarchies between experts and their subjects. In the context of mass mobilization, the essay considers “real estate” to be a fitting metaphor to describe the process through which potentially emancipatory projects fail to materialize within a toxic climate that tends to equate political critique with purity competitions and boundary work.
Endogenously expressed Ranbp2 is not at the axon initial segment
Authors: Ogawa Yuki , Rasband Matthew N. 
Published: February 2021

ABSTRACT
Ranbp2 (also known as Nup358) is a member of the nucleoporin family, which constitutes the nuclear pore complex. Ranbp2 localizes at the nuclear membrane and was recently reported at the axon initial segment (AIS). However, we show that the anti-Ranbp2 antibody used in previous studies is not specific for Ranbp2. We mapped the antibody binding site to the amino acid sequence KPLQG, which is present in both Ranbp2 and neurofascin (Nfasc), a well-known AIS protein. After silencing neurofascin expression in neurons, the AIS was not stained by the antibody. Surprisingly, an exogenously expressed N-terminal fragment of Ranbp2 localizes at the AIS. We show that this fragment interacts with stable microtubules. Finally, using CRISPR/Cas9 in primary cultured neurons, we inserted an HA-epitope tag at N-terminal, C-terminal or internal sites of the endogenously expressed Ranbp2. No matter the location of the HA-epitope, endogenous Ranbp2 was found at the nuclear membrane but not the AIS. These results show that endogenously expressed Ranbp2 is not found at AISs.
This article has an associated First Person interview with the first author of the paper.