bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repurposing Erythrocytes as a “Photoactivatable Bomb”: A General Strategy for Site‐Specific Drug Release in Blood Vessels
Authors: Zhu Ya‐Xuan , Jia Hao‐Ran , Guo Yuxin , Liu Xiaoyang , Zhou Ningxuan , Liu Peidang , Wu Fu‐Gen 
Published: July 2021

AbstractTumor vasculature has long been considered as an extremely valuable therapeutic target for cancer therapy, but how to realize controlled and site‐specific drug release in tumor blood vessels remains a huge challenge. Despite the widespread use of nanomaterials in constructing drug delivery systems, they are suboptimal in principle for meeting this demand due to their easy blood cell adsorption/internalization and short lifetime in the systemic circulation. Here, natural red blood cells (RBCs) are repurposed as a remote‐controllable drug vehicle, which retains RBC's morphology and vessel‐specific biodistribution pattern, by installing photoactivatable molecular triggers on the RBC membrane via covalent conjugation with a finely tuned modification density. The molecular triggers can burst the RBC vehicle under short and mild laser irradiation, leading to a complete and site‐specific release of its payloads. This cell‐based vehicle is generalized by loading different therapeutic agents including macromolecular thrombin, a blood clotting‐inducing enzyme, and a small‐molecule hypoxia‐activatable chemodrug, tirapazamine. In vivo results demonstrate that the repurposed “anticancer RBCs” exhibit long‐term stability in systemic circulation but, when tumors receive laser irradiation, precisely releases their cargoes in tumor vessels for thrombosis‐induced starvation therapy and local deoxygenation‐enhanced chemotherapy. This study proposes a general strategy for blood vessel‐specific drug delivery.
Professional Competence for Teaching Mathematical Modelling
Authors: Wess Raphael , Klock Heiner , Siller Hans-Stefan , Greefrath Gilbert 
Published: July 2021

AbstractProfessional competence is a widely discussed topic (see, e.g. Cochran-Smith & Fries, 2001; Darling-Hammond & Bransford, 2005) and was measured globally in various large-scale studies (see, e.g. Blömeke et al., 2014; Kunter et al., 2013). The dimensions for the subject of mathematics range from knowledge to mathematical content to pedagogical and didactic knowledge of teachers with the aim of bringing them together.
Holst-MacDowell-Mansouri action for (extended) supergravity with boundaries and super Chern-Simons theory
Authors: Eder K. , Sahlmann H. 
Published: July 2021

AbstractIn this article, the Cartan geometric approach toward (extended) supergravity in the presence of boundaries will be discussed. In particular, based on new developments in this field, we will derive the Holst variant of the MacDowell-Mansouri action for$$ \mathcal{N} $$N= 1 and$$ \mathcal{N} $$N= 2 pure AdS supergravity inD= 4 for arbitrary Barbero-Immirzi parameters. This action turns out to play a crucial role in context of boundaries in the framework of supergravity if one imposes supersymmetry invariance at the boundary. For the$$ \mathcal{N} $$N= 2 case, it follows that this amounts to the introduction of aθ-topological term to the Yang-Mills sector which explicitly depends on the Barbero-Immirzi parameter. This shows the close connection between this parameter and theθ-ambiguity of gauge theory.We will also discuss the chiral limit of the theory, which turns out to possess some very special properties such as the manifest invariance of the resulting action under an enlarged gauge symmetry. Moreover, we will show that demanding supersymmetry invariance at the boundary yields a unique boundary term corresponding to a super Chern-Simons theory with OSp($$ \mathcal{N} $$N|2) gauge group. In this context, we will also derive boundary conditions that couple boundary and bulk degrees of freedom and show equivalence to the results found in the D’Auria-Fré approach in context of the non-chiral theory. These results provide a step towards of quantum description of supersymmetric black holes in the framework of loop quantum gravity.
Supersymmetric interpretation of the muon g – 2 anomaly
Authors: Endo Motoi , Hamaguchi Koichi , Iwamoto Sho , Kitahara Teppei 
Published: July 2021

AbstractThe Fermilab Muong−2 collaboration recently announced the first result of measurement of the muon anomalous magnetic moment (g−2), which confirmed the previous result at the Brookhaven National Laboratory and thus the discrepancy with its Standard Model prediction. We revisit low-scale supersymmetric models that are naturally capable to solve the muong−2 anomaly, focusing on two distinct scenarios: chargino-contribution dominated and pure-bino-contribution dominated scenarios. It is shown that the slepton pair-production searches have excluded broad parameter spaces for both two scenarios, but they are not closed yet. For the chargino-dominated scenario, the models with$$ {m}_{{\tilde{\mu}}_{\mathrm{L}}}\gtrsim {m}_{{\tilde{\chi}}_1^{\pm }} $$mμ˜L≳mχ˜1±are still widely allowed. For the bino-dominated scenario, we find that, although slightly non-trivial, the region with low tanβwith heavy higgsinos is preferred. In the case of universal slepton masses, the low mass regions with$$ {m}_{\tilde{\mu}} $$mμ˜≲ 230 GeV can explain theg−2 anomaly while satisfying the LHC constraints. Furthermore, we checked that the stau-bino coannihilation works properly to realize the bino thermal relic dark matter. We also investigate heavy staus case for the bino-dominated scenario, where the parameter region that can explain the muong−2 anomaly is stretched to$$ {m}_{\tilde{\mu}} $$mμ˜≲ 1.3 TeV.
Jet angularities in Z+jet production at the LHC
Authors: Caletti Simone , Fedkevych Oleh , Marzani Simone , Reichelt Daniel , Schumann Steffen , Soyez Gregory , Theeuwes Vincent 
Published: July 2021

Abstract
We present a phenomenological study of angularities measured on the highest transverse-momentum jet in LHC events that feature the associate production of a Z boson and one or more jets. In particular, we study angularity distributions that are measured on jets with and without the SoftDrop grooming procedure. We begin our analysis exploiting state-of-the-art Monte Carlo parton shower simulations and we quantitatively assess the impact of next-to-leading order (NLO) matching and merging procedures. We then move to analytic resummation and arrive at an all-order expression that features the resummation of large logarithms at next-to-leading logarithmic accuracy (NLL) and is matched to the exact NLO result. Our predictions include the effect of soft emissions at large angles, treated as a power expansion in the jet radius, and non-global logarithms. Furthermore, matching to fixed-order is performed in such a way to ensure what is usually referred to as NLL′ accuracy. Our results account for realistic experimental cuts and can be easily compared to upcoming measurements of jet angularities from the LHC collaborations.
Strong CP problem and axion dark matter with small instantons
Authors: Kitano Ryuichiro , Yin Wen 
Published: July 2021

Abstract
The axion mass receives a large correction from small instantons if the QCD gets strongly coupled at high energies. We discuss the size of the new CP violating phases caused by the fact that the small instantons are sensitive to the UV physics. We also discuss the effects of the mass correction on the axion abundance of the Universe. Taking the small-instanton contributions into account, we propose a natural scenario of axion dark matter where the axion decay constant is as large as 1015-16 GeV. The scenario works in the high-scale inflation models.
BPS Skyrme submodels of the five-dimensional Skyrme model
Authors: Fadhilla Emir Syahreza , Gunara Bobby Eka , Atmaja Ardian Nata 
Published: July 2021

Abstract
In this paper, we search for the BPS skyrmions in some BPS submodels of the generalized Skyrme model in five-dimensional spacetime using the BPS Lagrangian method. We focus on the static solutions of the Bogomolny’s equations and their corresponding energies with topological charge B > 0 is an integer. We consider two main cases based on the symmetry of the effective Lagrangian of the BPS submodels, i.e. the spherically symmetric and non-spherically symmetric cases. For the spherically symmetric case, we find two BPS submodels. The first BPS submodels consist of a potential term and a term proportional to the square of the topological current. The second BPS submodels consist of only the Skyrme term. The second BPS submodel has BPS skyrmions with the same topological charge B > 1, but with different energies, that we shall call “topological degenerate” BPS skyrmions. It also has the usual BPS skyrmions with equal energies, if the topological charge is a prime number. Another interesting feature of the BPS skyrmions, with B > 1, in this BPS submodel, is that these BPS skyrmions have non-zero pressures in the angular direction. For the non-spherically symmetric case, there is only one BPS submodel, which is similar to the first BPS submodel in the spherically symmetric case. We find that the BPS skyrmions depend on a constant k and for a particular value of k we obtain the BPS skyrmions of the first BPS submodel in the spherically symmetric case. The total static energy and the topological charge of these BPS skyrmions also depend on this constant. We also show that all the results found in this paper satisfy the full field equations of motions of the corresponding BPS submodels.
Global Radioxenon Emission Inventory from Nuclear Research Reactors
Authors: Kalinowski Martin B. , Tayyebi Pouneh , Lechermann Michael , Tatlisu Halit 
Published: July 2021

AbstractTo monitor compliance with the Comprehensive Nuclear-Test-Ban Treaty (CTBT), the International Monitoring System (IMS) is being established which will include 40 sensor systems for atmospheric xenon radioactivity. Radioactive isotopes of the noble gas xenon provide the most likely observable radioactive signatures of underground nuclear explosions. These isotopes are frequently detected by IMS noble gas systems as a result of normal operational releases from different types of nuclear facilities including nuclear power plants (NPPs), medical isotope production facilities (MIPFs), and nuclear research reactors (NRRs). Improved knowledge of the contribution of different emission sources on IMS observations strengthens the screening of radioxenon measurements to exclude observations not relevant to emissions from a nuclear explosion. The contribution of NPPs and MIPFs to the global radioxenon emission inventory is fairly well understood. NRRs have yet to be systematically assessed. This paper is the first attempt to assess the total emission inventory of NRRs expressed as annual total discharges. The results can enhance understanding of those sources most likely to impact IMS background observations and to guide future studies on contributions to IMS station background.
Chirurgie periampullärer Pankreaskarzinome
Authors: Hank Thomas , Klaiber Ulla , Sahora Klaus , Schindl Martin , Strobel Oliver 
Published: July 2021

ZusammenfassungPeriampulläre Neoplasien sind eine heterogene Gruppe verschiedener Tumorentitäten der periampullären Region, von denen das Pankreasadenokarzinom mit 60–70 % am häufigsten ist. Wie typisch für Pankreaskarzinome zeichnen sich periampulläre Pankreaskarzinome durch ein aggressives Wachstum und eine frühe systemische Progression aus. Aufgrund ihrer besonderen Lage in unmittelbarer Nähe zur Papilla Vateri treten Symptome in eher früherem Tumorstadium auf, sodass die Therapiemöglichkeiten und Prognose insgesamt günstiger sind als bei Pankreaskarzinomen anderer Lokalisation. Trotzdem unterscheiden sich die Therapieprinzipien bei periampullären Pankreaskarzinomen nicht wesentlich von den Standards bei Pankreaskarzinomen anderer Lokalisation. Ein potenziell kurativer Therapieansatz beim nichtmetastasierten periampullären Pankreaskarzinom ist multimodal und besteht aus der Durchführung einer partiellen Duodenopankreatektomie als radikale onkologische Resektion in Kombination mit einer systemischen, meist adjuvant verabreichten Chemotherapie. Bei Patienten mit günstigen prognostischen Faktoren kann hierdurch ein Langzeitüberleben erzielt werden. Zudem wurden mit der Weiterentwicklung der Chirurgie und Systemtherapie auch potenziell kurative Therapiekonzepte für fortgeschrittene, früher irresektable Tumoren etabliert, welche nun nach Durchführung einer neoadjuvanten Therapie oft einer Resektion zugeführt werden können. In diesem Beitrag werden die aktuellen chirurgischen Prinzipien der radikalen onkologischen Resektion periampullärer Pankreaskarzinome im Kontext der multimodalen Therapie dargestellt und ein Ausblick auf mögliche künftige Entwicklungen der Therapie gegeben.
Covid and social distancing with a heterogenous population
Authors: Makris Miltiadis 
Published: July 2021

AbstractMotivated by the Covid-19 epidemic, we build a SIR model with private decisions on social distancing and population heterogeneity in terms of infection-induced fatality rates, and calibrate it to UK data to understand the quantitative importance of these assumptions. Compared to our model, the calibrated benchmark version with constant mean contact rate significantly over-predicts the mean contact rate, the death toll, herd immunity and prevalence peak. Instead, the calibrated counterfactual version with endogenous social distancing but no heterogeneity massively under-predicts these statistics. We use our calibrated model to understand how the impact of mitigating policies on the epidemic may depend on the responses these policies induce across the various population segments. We find that policies that shut down some of the essential sectors have a stronger impact on the death toll than on infections and herd immunity compared to policies that shut down non-essential sectors. Furthermore, there might not be an after-wave after policies that shut down some of the essential sectors are lifted. Restrictions on social distancing can generate welfare gains relative to the case of no intervention. Milder but longer restrictions on less essential activities might be better in terms of these welfare gains than stricter but shorter restrictions, whereas the opposite might be the case for restrictions on more essential activities. Finally, shutting down some of the more essential sectors might generate larger welfare gains than shutting down the less essential sectors.
The Vulcan salute sign: a non-sensitive but specific sign for Morton’s neuroma on radiographs
Authors: Galley Julien , Sutter Reto , Germann Christoph , Pfirrmann Christian W. A. 
Published: July 2021

Abstract
Objectives
To assess the value of the divergence of toes on conventional radiographs of the foot for diagnosing Morton’s neuroma.

Methods
This retrospective case–control study was approved by the local ethics committee. In 100 patients with MRI-proven Morton’s neuroma 2/3 or 3/4 (study group) and 100 patients without (control group), conventional weight-bearing dorso-plantar view radiographs were evaluated for the subjective presence of interphalangeal divergence, called the Vulcan salute sign or V-sign, by two blinded, independent musculoskeletal radiologists. Interphalangeal angles (2/3 and 3/4) and intermetatarsal angle I/V were measured. The t test and chi-squared test were used to compare the groups. Diagnostic performance was calculated. Interobserver reliability was assessed using κ statistics and intraclass correlation coefficient (ICC).

Results
The difference between the groups was significant (P < 0.05) regarding the presence of the V-sign, which was found in 30 of 100 patients with Morton neuroma and in 3 of 100 control patients, with a sensitivity of 30% and a specificity of 97%. The differences between interphalangeal angles were significant (P < 0.05) between the groups. The interphalangeal angle 2/3 mean values were 7.9° (± 4.8) for the study group vs 5.4° (± 2.6) for the controls; the 3/4 angle values were 6.5° (± 3.8) and 3.4° (± 2.5), respectively. There was no significant difference between the groups in the intermetatarsal angle I/V. Interobserver agreement was substantial for the V-sign, with a κ value of 0.78. The ICC was excellent concerning angle measurements, with all values ≥ 0.94.

Conclusion
The Vulcan salute sign on conventional radiographs is specific for Morton’s neuroma.
BRAF testing in metastatic colorectal carcinoma and novel, chemotherapy-free therapeutic options
Authors: Hummel Michael , Hegewisch-Becker Susanna , Neumann Jens H. L. , Vogel Arndt 
Published: July 2021

AbstractIn the past 25 years, treatment of metastatic colorectal cancer (mCRC) has undergone profound changes. The approval of newer chemotherapeutics such as irinotecan and oxaliplatin was followed in 2005 by the first targeted therapies, for example, monoclonal antibodies directed against the epidermal growth factor receptor (EGFR), as cetuximab and panitumumab, or the angiogenesis inhibitors bevacizumab, ramucirumab, and aflibercept. With the rapidly progressing molecular characterization of mCRC in the last 10 years and the classification of the disease in four consensus subtypes, further changes are emerging, which will promote, among other things, the introduction of protein-kinase inhibitors developed for specific molecular aberrations as well as immune checkpoint inhibitors into the treatment algorithm.Thorough molecular pathologic testing is indispensable today for guideline-compliant treatment of mCRC patients. In addition to RAS testing as a precondition for the therapy decision with regard to cetuximab and panitumumab, BRAF testing is of considerable relevance to allow decision making with regard to the newly approved chemotherapy-free combination of the BRAF inhibitor encorafenib and cetuximab in cases where a BRAF-V600E mutation is detected. Additional diagnostic tests should also include genome instability (microsatellite instability). Overall, more and more molecular alterations need to be investigated simultaneously, so that the use of focused next-generation sequencing is increasingly recommended.This overview describes the prognostic relevance of BRAF testing in the context of molecular pathologic diagnostics of mCRC, presents new treatment options for BRAF-mutated mCRC patients, and explains which modern DNA analytical and immunohistochemical methods are available to detect BRAF mutations in mCRC patients.
Prognostic impact of molecular muscle-invasive bladder cancer subtyping approaches and correlations with variant histology in a population-based mono-institutional cystectomy cohort
Authors: Weyerer Veronika , Stoehr Robert , Bertz Simone , Lange Fabienne , Geppert Carol I. , Wach Sven , Taubert Helge , Sikic Danijel , Wullich Bernd , Hartmann Arndt , Eckstein Markus 
Published: July 2021

Abstract
Purpose
Recently discovered molecular classifications for urothelial bladder cancer appeared to be promising prognostic and predictive biomarkers. The present study was conducted to evaluate the prognostic impact of molecular subtypes assessed by two different methodologies (gene and protein expression), to compare these two approaches and to correlate molecular with histological subtypes in a consecutively collected, mono-institutional muscle-invasive bladder cancer (MIBC) cohort.

Methods
193 MIBC were pathologically re-evaluated and molecular subtypes were assessed on mRNA (NanoString technology, modified 21-gene-containing MDACC approach) and protein levels (immuno-histochemical [IHC] analysis of CK5, CK14, CD44, CK20, GATA3 and FOXA1). Descriptive statistical methods and uni-/multi-variable survival models were employed to analyze derived data.

Results
Neither gene expression nor protein-based subtyping showed significant associations with disease-specific (DSS) or recurrence-free survival (RFS). Agreement between mRNA (reference) and protein-based subtyping amounted 68.6% for basal, 76.1% for luminal and 50.0% for double-negative tumors. Histological subtypes associated with RFS in uni-variable (P = 0.03), but not in multivariable survival analyses. Tumors with variant histology predominantly showed luminal subtypes (gene expression subtyping: 36/55 cases, 65.5%; protein subtyping: 44/55 cases, 80.0%). Squamous differentiation significantly associated with basal subtypes (gene expression subtyping: 44/45 squamous cases, 97.8%; protein subtyping: 36/45 cases, 80.0%).

Conclusion
In our consecutive cystectomy cohort, neither gene, protein expression-based subtyping, nor histological subtypes associated with DSS or RFS in multi-variably adjusted survival analyses. Application of a limited IHC subtyping marker panel showed high concordance of 83.9% with gene expression-based subtyping, thus underlining the utility for subtyping in pathological routine diagnostics. In addition, histological MIBC subtypes are strong indicators for intrinsic subtypes.
Searching for improvements in predicting human eye colour from DNA
Authors: Kukla-Bartoszek Magdalena , Teisseyre Paweł , Pośpiech Ewelina , Karłowska-Pik Joanna , Zieliński Piotr , Woźniak Anna , Boroń Michał , Dąbrowski Michał , Zubańska Magdalena , Jarosz Agata , Płoski Rafał , Grzybowski Tomasz , Spólnicka Magdalena , Mielniczuk Jan , Branicki Wojciech 
Published: July 2021

AbstractIncreasing understanding of human genome variability allows for better use of the predictive potential of DNA. An obvious direct application is the prediction of the physical phenotypes. Significant success has been achieved, especially in predicting pigmentation characteristics, but the inference of some phenotypes is still challenging. In search of further improvements in predicting human eye colour, we conducted whole-exome (enriched in regulome) sequencing of 150 Polish samples to discover new markers. For this, we adopted quantitative characterization of eye colour phenotypes using high-resolution photographic images of the iris in combination with DIAT software analysis. An independent set of 849 samples was used for subsequent predictive modelling. Newly identified candidates and 114 additional literature-based selected SNPs, previously associated with pigmentation, and advanced machine learning algorithms were used. Whole-exome sequencing analysis found 27 previously unreported candidate SNP markers for eye colour. The highest overall prediction accuracies were achieved with LASSO-regularized and BIC-based selected regression models. A new candidate variant, rs2253104, located in theARFIP2gene and identified with the HyperLasso method, revealed predictive potential and was included in the best-performing regression models. Advanced machine learning approaches showed a significant increase in sensitivity of intermediate eye colour prediction (up to 39%) compared to 0% obtained for the original IrisPlex model. We identified a new potential predictor of eye colour and evaluated several widely used advanced machine learning algorithms in predictive analysis of this trait. Our results provide useful hints for developing future predictive models for eye colour in forensic and anthropological studies.