bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of pharmacist interventions associated with insulin prescribing for hospital inpatients with diabetes
Authors: Zipf Nathan , Grant Lauren , Robinson Brent , Teasdale Trudy , Grant Gary , Hattingh Hendrika Laetitia 
Published: March 2021

Abstract
Background: Insulin is a high-risk medicine, associated with hospital medication errors. Pharmacists play an important role in the monitoring of patients on insulin. Objective: To analyse interventions made by hospital pharmacists that were associated with insulin prescribing for inpatients with diabetes.Method: Retrospective audit of pharmacist interventions for adult inpatients for an 8-month period, 1 June 2019 to 31 January 2020. Pharmacist interventions recorded in the electronic medication management system by inpatient unit and dedicated high-risk medicine pharmacists were extracted, screened, and analysed.Results: Of 3,975 pharmacist interventions 3,356 (84.43%) were recorded by high-risk medicine pharmacists and 619 (15.57%) by inpatient unit pharmacists. July and August 2019 had the highest numbers of interventions with 628 and 643 (15.80% and 16.18%) respectively. Most of the interventions, namely 3,410 (85.79%) were classified as medicine optimisation interventions and 565 (14.21%) as prescribing errors. In the medicine optimisation intervention category, 2,985 (75.09%) were due to insulin not charted for ongoing administration.Conclusion: This study provides insights into pharmacist interventions for inpatients on insulin, showing that high-risk medicine pharmacists recorded most interventions. The classification of the insulin interventions into medicine optimisation and prescribing errors provides useful information for the training of prescribers in insulin management.
A system-oriented strategy to enhance electron production of Synechocystis sp. PCC6803 in bio-photovoltaic devices: experimental and modeling insights
Authors: Firoozabadi Hossein , Mardanpour Mohammad Mahdi , Motamedian Ehsan 
Published: March 2021

Abstract
Bio-photovoltaic devices (BPVs) harness photosynthetic organisms to produce bioelectricity in an eco-friendly way. However, their low energy efficiency is still a challenge. A comprehension of metabolic constraints can result in finding strategies for efficiency enhancement. This study presents a systemic approach based on metabolic modeling to design a regulatory defined medium, reducing the intracellular constraints in bioelectricity generation of Synechocystis sp. PCC6803 through the cellular metabolism alteration. The approach identified key reactions that played a critical role in improving electricity generation in Synechocystis sp. PCC6803 by comparing multiple optimal solutions of minimal and maximal NADH generation using two criteria. Regulatory compounds, which controlled the enzyme activity of the key reactions, were obtained from the BRENDA database. The selected compounds were subsequently added to the culture media, and their effect on bioelectricity generation was experimentally assessed. The power density curves for different culture media showed the BPV fed by Synechocystis sp. PCC6803 suspension in BG-11 supplemented with NH4Cl achieved the maximum power density of 148.27 mW m-2. This produced power density was more than 40.5-fold of what was obtained for the BPV fed with cyanobacterial suspension in BG-11. The effect of the activators on BPV performance was also evaluated by comparing their overpotential, maximum produced power density, and biofilm morphology under different conditions. These findings demonstrated the crucial role of cellular metabolism in improving bioelectricity generation in BPVs.
Association of variants m.T16172C and m.T16519C in whole mtDNA sequences with high altitude pulmonary edema in Han Chinese lowlanders
Authors: Wang Yan , Huang Xuewen , Peng Fujun , Han Huiling , Gu Yanan , Liu Xin , Feng Zhichun 
Published: March 2021

Abstract
Background: High altitude pulmonary edema (HAPE) is a hypoxia-induced non-cardiogenic pulmonary edema that typically occurred in un-acclimatized lowlanders, which inevitably leads to life-threatening consequences. Apart from multiple factors involved, the genetic factors also play an important role in the pathogenesis of HAPE. So far, researchers put more energy into the nuclear genome and HAPE, and ignored the relationship between the mitochondrion DNA (mtDNA) variants and HAPE susceptibility. Methods: We recruited a total of 366 individuals including 181 HAPE patients and 185 healthy or non-HAPE populations through two times. The first time, 49 HAPE patients and 58 non-HAPE cases were performed through whole mtDNA sequences to search the mutations and haplogroups, which were associated with the HAPE. The second time, 132 HAPE patients and 127 non-HAPE subjects were collected to apply of verifying these variants and haplogroups of mtDNA with routine PCR method. Results: We analyzed and summarized the clinical characteristics and sequence data for 49 HAPE patients and 58 non-HAPE cases. We found that a series of routine blood indexes including systolic arterial blood pressure (SBP), heart rate (HR), white blood cell (WBC) and C-reactive protein (CRP) in HAPE group presented higher and displayed the significant differences compared with those in non-HAPE group. Though the average numbers of variants in different regions and groups samples were not statistically significant (P > 0.05), the mutation densities of different region in the internal group shown the significant differences. Then we found that two mutations (T16172C and T16519C) associated with the HAPE susceptibility, and the T16172C mutation increased the risk of HAPE, and the T16519C mutation decreased the HAPE rating. Furthermore, the two mutations were demonstrated with 132 HAPE cases and 127 non-HAPE individuals. Unfortunately, all the haplogroups were not associated with the HAPE haplogroups.Conclusions: We provided the evidence of differences in mtDNA polymorphism frequencies between HAPE and non-HAPE Han Chinese. Genotypes of mtDNA 16172C and 16519C were correlated with HAPE susceptibility, which indicated that the role in mitochondrial genome in the pathogenesis of HAPE.
Ethnobotanical Study of Medicinal Plants Used for Human Health Care in Yem Culture, South Ethiopia
Authors: Woldemariam Gideon , Demissew Sebsebe , Asfaw Zemede 
Published: March 2021

Abstract
BackgroundIndigenous or traditional herbal medicine has been widely regarded as a resource for strengthening the health care systems among communities of low income countries including Ethiopia. The Yem people in Ethiopia have deep-rooted and ancient traditional knowledge of managing human ailments and health conditions using medicinal plants (mps). On the other hand, mps and the associated indigenous knowledge are under erosion due to human-induced and natural factors. Therefore, documenting the plant biodiversity along with the associated indigenous knowledge is of urgent task for conservation. MethodsThis study was conducted in April, 2013, October, 2016 and July, 2016 with the objective of documenting traditional mps in different land uses that are used for treating human ailments. Ethnobotanical data were collected from 69 informants that were selected by stratified random sampling and purposive sampling. Vegetation data were obtained from 30, 30x30 m quadrats. Ethnobotanical data were analysed using paired ranking, Informant consensus factor and Fidelity Level index. ResultsAbout 213 medicinal plant species that are used for treating 117 human ailments were recorded. ICF calculated depicted a highest ICF value of 0.82 for Gastrointestinal & Visceral organs ailments. Haplocarpha rueppellii, Carduus schimperi and Inula confortiflora each 100%, Maesa lanceolata 80% and Rumex abyssinicus 75%. Vegetation analysis showed three plant communities.ConclusionThe Yem people have rich traditional knowledge of utilising plants side by side with the mainstream biomedical system for maintaining human health care.
Geotechnical Seismic Vulnerability Assessment of Puerto Vallarta, México
Authors: Escudero Christian R , Gaytan Alejandro Ramirez , Camacho Araceli Zamora , Preciado Adolfo , Flores Karen L. , Hernandez Adan Gomez 
Published: March 2021

Abstract
We performed a seismic vulnerability assessment that involves geotechnical and building structure analysis for Puerto Vallarta, Mexico, a city located along the pacific coast. Like many other Latin American cities, has significant seismic risk. We implemented the multi-channel analysis of surface waves and the horizontal-to-vertical spectral ratio methods to estimate shear wave velocity and soil resonance frequency. We considered standard penetration test to determine the penetration resistance and soil classification. We also defined building typologies based on construction materials and structural systems. The VS30 parameter shows that Puerto Vallarta has the three poorest soil classifications. The resonance frequency parameter shows four zones with different fundamental soil periods. We inferred the building's vulnerability from the coupling between the structural and soil fundamental period and the soil characteristics. The analysis shows several vulnerable buildings scatters within the city, e.g., within the tourist area, confined masonry buildings from one to five stories and moment resistance frame buildings up to 12 in the tourist area, poorly confined masonry houses of one to two stories, and confined masonry buildings of one to five stories in the residential/commercial. We present an approach that combines the academic and government to solve a real and transcendental problem since it might directly affect the regulation and structure evaluations in the area. We are sure that these exercises are of great interest in urban growth areas in other parts of the world, especially in Latin America, to achieve seismic risk mitigation.
Recent Trends in Precipitation Over the Myanmar Coast During Onset and Withdrawal Phases of Monsoon Season
Authors: Yan Xiao , Yao Yibin , Yang Yuanjian , Zhang Liang , Zhang Bao 
Published: March 2021

Abstract
Monsoon precipitation is the major driver of agricultural productivity in the Myanmar Coast, it is crucial to quantify and understand recent changes in precipitation during the monsoon season over this region. By using multiple precipitation datasets, we demonstrate that total precipitation during monsoon season over the Myanmar Coast has increased slightly but not significantly, but precipitation during the onset and withdrawal phases of monsoon season exhibit a significant increasing trend during 1979–2015, and the contribution of precipitation during the two phases to total monsoon precipitation has increased significantly. The increased precipitation during the onset phase over the Myanmar Coast directly results from the earlier onset of the South Asian Summer Monsoon in recent decades, which is associated with the phase transition of the Inter-decadal Pacific Oscillation in the late 1990s. And the precipitation increase during the withdrawal phase is directly due to the enhances of the ascending motion and convection around this region, which is dynamically correlated to the anomalous cyclone-like circulation around the Bay of Bengal as well as the strengthening of the cross-equatorial flow around the equatorial Indian Ocean.
Thermography as a Non-ionizing Quantitative Tool for Diagnosing Endo-perio Lesions
Authors: Aboushady M. Atef , Talaat Wael , Hamdoon Zaid , Elshazly Tarek , Ragy Nivin , Bourauel Christoph , Talaat Sameh 
Published: March 2021

Abstract
Background: Thermography is a contemporary imaging modality based on acquiring and analyzing thermal data using non-contact devices. The aim of the present study was to assess the validity of thermography, compared with that of the gold standard, for the diagnosis of endo-perio lesions and to evaluate the temperature ranges for acute pulpitis with apical periodontitis (AAP), acute periapical abscess (AA) and chronic periapical abscess (CA).Methods: AAP, AA and CA were diagnosed based on clinical and radiographic criteria. Thermographic data were acquired using the FLIR E-5 Infrared Camera. Extraoral thermal images were taken from the front and right and left sides of patients whose mouths were closed, and one intraoral thermal image was taken from the palatal perspective. Agreement in the diagnoses based on the combination of clinical and radiographic assessments and the thermographic evaluation was calculated. The temperature ranges of the three subdiagnostic groups were also measured.Results: A total of 80 patients were enrolled in this study. The mean thermal image temperature for AA was 37.26±0.36, that for CA was 35.03±0.63 and that for AAP was 36.07±0.45. The differences between the mean thermal temperatures of the three diagnostic groups were highly statistically significant (P<0.001). The result of the Kappa coefficient of agreement between the combination of clinical and radiographic assessments and the thermographic evaluation was highly significant (P<0.001). The rates of change in temperature with time for each diagnostic group were highly statistically significantly different (P<0.001).Conclusions: Thermography is an effective, quantitative and nonionizing approach that can be used for the diagnosis of endo-perio lesions. This technology is able to distinguish different forms of infection by identifying the range of temperature increases related to each form.
Effects of combined carbohydrate and protein supplementation on athletic performance and recovery of endurance runners：a double blind, random trial
Authors: Liang Yiheng , Yang Fan , Chen Yan , Geng Guoqiang , Lu Mingyue , Gao Ruirui , Yi Longyan , Qiu Junqiang 
Published: March 2021

Abstract
Background

The aim of this study is to explore the effects of ingesting protein supplementation before endurance exercise.
Methods

10 recreationally active male runners (VO2max: 53.61±3.86 ml/kg•min) completed a run-to-exhaustion test three times. Each test involved 90 minutes of running at 70% VO2max, followed by a time to exhausted test for running at 80% VO2max. All subjects ingested three different, randomly assigned, supplement before the first phase. At the end of the first phase, CHO (carbohydrate) + CHO; PRO (protein) + CHO; CHO + PRO. Both carbohydrate and protein were supplemented at 0.4g•kg− 1BM− 1. Blood samples were obtained before, immediately after and 24 h after exercise for alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and myoglobin (MB).
Results

Three different supplement regimens did not cause a significant difference in exhaustion time (CHO + CHO: 432.36 ± 225.51s; PRO + CHO: 463.82 ± 227.45s; CHO + PRO: 461.45 ± 248.5s). However, ALT and AST in PRO + CHO were significantly lower than CHO + CHO 24h after exercise (ALT: 16.8 ± 6.31 VS. 24.39 ± 2.54 U/L; AST: 24.06 ± 4.77 VS. 31.51 ± 7.53 U/L, p < 0.05), and MB in PRO + CHO and CHO + PRO were significantly lower than CHO + CHO 24 h after exercise (40.71 ± 15.16; 38.12 ± 14.32; 64.32 ± 28.86 ng/mL, respectively, p < 0.05). Compared to CHO + CHO, CK in PRO + CHO increased less 24 h after exercise (404.22 ± 75.31 VS. 642.33 ± 68.57 U/L, p < 0.05).
Conclusion

Although combined carbohydrate and protein supplementation did not prolong exhaustion time, it can effectively relieve muscle damage, and it is better to supplement PRO before exercise.
Propranolol and Somatostatin Agonist Therapy Resulting in Symptom Improvement and Stabilization of von Hippel-Lindau-Associated Hemangioblastoma: A Case Report
Authors: Ilanchezhian Maran , Alvarez Reinier , Carbonell Amanda , Widemann Brigitte C. , Chittiboina Prashant , Rivero Jaydira Del 
Published: March 2021

Abstract
Von Hippel-Lindau disease is an inherited, autosomal dominant tumor predisposition syndrome which leads to susceptibility for developing hemangioblastomas of the central nervous system and retina, as well as other tumor types. No approved systemic therapies exist for this disease. Here, we present a patient diagnosed with Von Hippel-Lindau disease, with central nervous system and retinal hemangioblastomas, treated with propranolol and subsequently with Lanreotide. On both treatments, the patient showed notable symptom improvement. In addition, since starting Lanreotide, the patients hemangioblastoma has remained stable on imaging. Based on the symptom improvement in this patient and other reported findings in the literature, propranolol and somatostatin agonist therapy may have an anti-tumor effect in Von Hippel-Lindau associated hemangioblastomas; however, further investigation is warranted.
Green Supplier Selection in New Era for Sustainability: A Novel Method for Integrating Big Data Analytics and a Hybrid Fuzzy Multi-Criteria Decision Making
Authors: YILDIZBASI Abdullah , ARIOZ Yağmur 
Published: March 2021

Abstract
Environmentally conscious supplier selection has become increasingly important in recent years. Green supplier selection is one of the vital decisions of supply chain management, as it is preferred for businesses in the market that adopt an environmental approach and green philosophy in line with material and moral benefits. In this context, the problem of choosing the most efficient green supplier is addressed with a three-step methodology using big data analysis that includes an integrated approach and hybrid fuzzy AHP-TOPSIS techniques. First of all, big data plays an important role in delivering meaningful results by reducing complexity to a more fundamental level. It is possible to obtain more consistent results by examining a series of criteria in green supplier selection at a more reasonable and operational level. Thus, the role of big data analysis provides an input for decision-making, which enables a systematic reduction to more concise data. Then, these inputs are evaluated in a fuzzy environment with hybrid MCDM techniques and the most efficient green supplier is determined among the suppliers. This authentic study sheds light on providing a significant competitive advantage to businesses in line with their strategic targets as well as having environmental contributions to sustainability.
Flexible ZnO photoelectrode for photo electrochemical energy conversion
Authors: Shiyani T. , Banerjee Indrani , Mahapatra Santosh K. , Ray Asim K 
Published: March 2021

Abstract
Photoelectrochemical properties have been investigated for flexible ZnO/ITO/PET photoelectrodes. ZnO was spin coated on ITO/PET substrate with thickness of about 310 nm. The high crystalline structure of ZnO was studied using x-ray diffraction pattern. A value of 3.4 eV has been estimated for optical band gap from its absorption spectra. The flexible ZnO photoelectrode was demonstrated to generate photoelectrochemical current. Values of 1.022 and 0.714 were found to be for photo switching and photoresponsivity, respectively. ZnO/ITO/PET can be used as a substrate for making flexible hybrid PEC devices to generate solar power and solar fuels.
Kinetics of HE4 and CA125 as prognosis biomarkers during neoadjuvant chemotherapy in advanced epithelial ovarian cancer
Authors: Alegría-Baños Jorge A. , Jiménez-López José C. , Vergara-Castañeda Arely , de León David F. Cantú , Mohar-Betancourt Alejandro , Pérez-Montiel Delia , Sánchez-Domínguez Gisela , García-Villarejo Mariana , Olivares-Pérez César , Hernández-Constantino Ángel , González-Santiago Acitlalin , Clara-Altamirano Miguel A. , Arela-Quispe Liz , Prada-Ortega Diddier G. 
Published: March 2021

Abstract
Background
Ovarian cancer (OC) is considered the most lethal gynecological cancer, of which more than 65% cases are diagnosed in advanced stages, requiring platinum-based neoadjuvant chemotherapy (NACT).
Methods
A prospective-longitudinal study was conducted among women with advanced epithelial ovarian cancer (AEOC), III and IV stages, and treated with NACT, at the National Cancer Institute – Mexico, from July 2017 to July 2018. Serum samples were obtained for quantification of CA125 and HE4 using ELISA at the first and in each of the three NACT cycles. The therapeutic response was evaluated through standard tomography. We determined whether CA125 and HE4, alone or in combination, were associated with TR to NACT during follow up.
Results
53 patients aged 38 to 79 years were included, 92.4% presented papillary serous subtype OC. Higher serum HE4 levels were observed in patients with non-tomographic response (6.89 vs 5.19 pmol/mL; p = 0.031), specially during the second (p = 0.039) and third cycle of NACT (p = 0.031). Multivariate-adjusted models showed an association between HE4 levels and TR, from the second treatment cycle (p = 0.042) to the third cycle (p = 0.033). Changes from baseline HE4 levels during the first cycle was negative associated with TR. No associations were found between CA125 and TR.
Conclusions
Serum HE4 levels were independently associated with TR among patients with AOEC treated with NACT, also a reduction between baseline HE4 and first chemotherapy levels was also independently associated with the TR. These findings might be relevant for predicting a lack of response to treatment.
GP-DMD: A Genetic Programming variant with Dynamic Management of Diversity
Authors: Fuentes Ricardo Nieto , Segura Carlos 
Published: March 2021

Abstract
The proper management of diversity is essential to the success of Evolutionary Algorithms. Specifically, methods that explicitly relate the amount of diversity maintained in the population to the stopping criterion and elapsed period of execution, with the aim of attaining a gradual shift from exploration to exploitation, have been particularly successful. However, in the area of Genetic Programming (GP), the performance of this design principle has not been studied. In this paper, a novel GP variant, Genetic Programming with Dynamic Management of Diversity (GP-DMD), is presented. GP-DMD applies this novel design principle through a replacement strategy that combines penalties based on distance-like functions with a multi-objective Pareto selection based on maximizing accuracy and minimizing tree size. The experimental validation based on the symbolic regression task considers several state-of-the-art approaches and shows clear improvements both in terms of accuracy and simplicity. The effects of GP-DMD on the dynamics of the population are also analyzed, revealing the reasons for the superiority of GP-DMD. As in other fields of Evolutionary Computation, this design principle contributes significantly to the area of GP.