bluuebunny/crossref_metadata_2025_split huggingface dataset:
The origins of time compression diseconomies
Authors: Srikanth Kannan , Anand Jaideep , Stan Mihaela 
Published: May 2021

AbstractResearch SummaryThat capability development is subject to time compression diseconomies (TCD) is well‐known in the strategy literature. However, so far, there is limited attention paid to its origins, that is, why it exists, and demonstrating it empirically. In the context of fertility clinics in the United Kingdom, we show that faster experience accumulation is associated with lower success rates; that is, time compression in experience accumulation results in shallower learning curves. We also show that TCD is exacerbated for clinics that mainly treat complex cases and is mitigated for clinics that employ an integrator to coordinate across the different specialist functions involved in the treatment process. We propose differential learning rates as the mechanism that underlies TCD, and develop implications for firm capabilities and sources of competitive advantage.Managerial SummaryAs firms pursue new opportunities, it is intuitive to grow fast. Rapid growth has many advantages, including a quicker payback on investment as well as garner first mover advantages. However, there can also be a dark side to such high paced growth. By analyzing data on in‐vitro fertilization clinics in the United Kingdom, we show that clinics that grew the fastest were slower in improving their treatment success rates, while slower growing clinics improved more with increasing experience. This penalty of rapid growth is more severe for clinics that treat more complex cases, but it can be ameliorated by better coordination between specialist activities. Our research serves as a warning that faster is not always better.
Single‐Atomic Site Catalyst with Heme Enzymes‐Like Active Sites for Electrochemical Sensing of Hydrogen Peroxide
Authors: Ding Shichao , Lyu Zhaoyuan , Fang Lingzhe , Li Tao , Zhu Wenlei , Li Suiqiong , Li Xin , Li Jin‐Cheng , Du Dan , Lin Yuehe 
Published: May 2021

AbstractHeme enzymes, with the pentacoordinate heme iron active sites, possess high catalytic activity and selectivity in biosensing applications. However, they are still subject to limited catalytic stability in the complex environment and high cost for broad applications in electrochemical sensing. It is meaningful to develop a novel substitute that has a similar structure to some heme enzymes and mimics their enzyme activities. One emerging strategy is to design the Fe‐N‐C based single‐atomic site catalysts (SASCs). The obtained atomically dispersed Fe‐Nx active sites can mimic the active sites of heme enzymes effectively. In this work, a SASC (Fe‐SASC/NW) is synthesized by doping single iron atoms in polypyrrole (PPy) derived carbon nanowire via a zinc‐atom‐assisted method. The proposed Fe‐SASC/NW shows high heme enzyme‐like catalytic performance for hydrogen peroxide (H2O2) with a specific activity of 42.8 U mg−1. An electrochemical sensor based on Fe‐SASC/NW is developed for the detection of H2O2. This sensor exhibits a wide detection concentration range from 5.0 × 10−10 m to 0.5 m and an excellent limit of detection (LOD) of 46.35 × 10−9 m. Such excellent catalytic activity and electrochemical sensing sensitivity are attributed to the isolated Fe‐Nx active sites and their structural similarity with natural metalloproteases.
Nucleus‐Targeted Delivery of Multi‐Protein Self‐Assembly for Combined Anticancer Therapy
Authors: Tang Jiakun , Liu Ye , Qi Dongmei , Yang Lan , Chen Hui , Wang Chenhui , Feng Xuli 
Published: May 2021

AbstractProtein therapy has the potential to revolutionize medicine, but the delivery of multiple proteins is challenging because it requires the development of a strategy that enables different proteins to be combined together and transported not only into cells, but also to the desired cell compartments, such as the nucleus. Here, an efficient intranuclear protein delivery nanoplatform based on modified ribonuclease A (RNase A) tuned self‐assembly is presented. RNase A bioreversibly modified with adamantane is functionalized with wind chime‐like lysine modified cyclodextrin (WLC) to generate RNase A‐WLC (R‐WLC). R‐WLC can not only enhance the cellular uptake of RNase A and accumulate it into the nucleus, but also works as nanovehicles to efficiently transport deoxyribonuclease I (DNase I) into the nucleus, resulting in greatly improved antitumor efficacy in vitro and in vivo. This protein co‐assembly strategy can be applied to other functional proteins and has great prospects in the treatment of many diseases.
Science engagement as insight into the science identity work nurtured in community‐based science clubs
Authors: Burke Lydia E. Carol‐Ann , Navas Iannini Ana Maria 
Published: May 2021

AbstractIn this article, we explore how children of late elementary to middle school age, from low‐income communities in an East‐Central metropolitan area of Canada, described their interests in and attitudes toward science in an out‐of‐school science club program. We used the children's descriptions of emotional engagement to gain insights into the identity work being carried out in the science club. Our analysis was based on survey responses from 202 children enrolled for at least one academic year in the science club program at 21 different club sites and focus group commentary from a subset of 45 children attending 14 of the clubs. We added context to the children's perspectives by including commentary from semistructured interviews with nine science club staffers and insights from field notes made after club promotional events. Analysis revealed the enthusiasm of children and/or their families for science education prior to engaging with the clubs. The children's anticipation that club science would reflect their school‐based science experiences was quickly dispelled by the hands‐on nature of club activities and the positive relationships built with club staffers. Of concern was the finding that staff and children frequently reinforced a rigid dichotomy between school and club science. This distinction meant that, although children described themselves as improving their performance in school science, they often found it difficult to relate the fun enacted during club sessions to the learning that is required during school science classes. This finding is problematic given the club's focus on keeping children's options in formal and informal science education open for as long as possible. The paper concludes by using the insights provided by children and club staffers to propose ways of enhancing the club/school/home science connection to better support transfer of the positive outcomes of the club‐based science identity work.
Endoscope and image‐guided ventral bulla osteotomy in the dog: A cadaveric and patient study
Authors: Bhutta Mahmood F. , Morrison Linda R. , Kureshi Munir 
Published: May 2021

Background: Surgery of the bulla in the dog can be difficult and associated with suboptimal resolution of disease and risk of complications, particularly in treatment of cholesteatoma. We explored use of image guidance and endoscopic assistance in ventral bulla osteotomy (VBO), initially with cadaveric studies and subsequently on dogs with cholesteatoma.Methods: For surgical approach we used cone beam CT with an optical image navigation system. For endoscopic surgery we used 4 mm and 2.7 mm diameter endoscopes and a camera viewing system, with micro‐instruments for dissection.Results: Image guidance allowed us to accurately identify and approach the bulla in cadavers (n= 2) and patients (n= 2). The endoscope enabled us to define detailed endoscopic anatomy in cadaveric canine heads (n= 15), and in patients (n= 5) it enabled reliable and safe removal of pathological tissue.Conclusion: Image and endoscopic assistance could be a significant advance to the reliability and safety of VBO. Our techniques may be applicable to other indications and species.
Two paths towards precision at a very high energy lepton collider
Authors: Buttazzo Dario , Franceschini Roberto , Wulzer Andrea 
Published: May 2021

Abstract
We illustrate the potential of a very high energy lepton collider (from 10 to 30 TeV center of mass energy) to explore new physics indirectly in the vector boson fusion double Higgs production process and in direct diboson production at high energy. Double Higgs production is found to be sensitive to the anomalous Higgs trilinear coupling at the percent level, and to the Higgs compositeness ξ parameter at the per mille or sub-per mille level thanks to the measurement of the cross-section in the di-Higgs high invariant mass tail. High energy diboson (and tri-boson) production is sensitive to Higgs-lepton contact interaction operators at a scale of several tens or hundred TeV, corresponding to a reach on the Higgs compositeness scale well above the one of any other future collider project currently under discussion. This result follows from the unique capability of the very high energy lepton collider to measure Electroweak cross-sections at 10 TeV energy or more, where the effect of new physics at even higher energy is amplified. The general lesson is that the standard path towards precision physics, based on measurements of high-statistics processes such as single and double Higgs production, is accompanied at the very high energy lepton collider by a second strategy based on measurements at the highest available energy.
Multiple cellular compartments engagement in Nicotiana benthamiana-peanut stunt virus-satRNA interactions revealed by systems biology approach
Authors: Wrzesińska Barbara , Zmienko Agnieszka , Vu Lam Dai , De Smet Ive , Obrępalska-Stęplowska Aleksandra 
Published: May 2021

Abstract
Key message
PSV infection changed the abundance of host plant’s transcripts and proteins associated with various cellular compartments, including ribosomes, chloroplasts, mitochondria, the nucleus and cytosol, affecting photosynthesis, translation, transcription, and splicing.

Abstract
Virus infection is a process resulting in numerous molecular, cellular, and physiological changes, a wide range of which can be analyzed due to development of many high-throughput techniques. Plant RNA viruses are known to replicate in the cytoplasm; however, the roles of chloroplasts and other cellular structures in the viral replication cycle and in plant antiviral defense have been recently emphasized. Therefore, the aim of this study was to analyze the small RNAs, transcripts, proteins, and phosphoproteins affected during peanut stunt virus strain P (PSV-P)–Nicotiana benthamiana interactions with or without satellite RNA (satRNA) in the context of their cellular localization or functional connections with particular cellular compartments to elucidate the compartments most affected during pathogenesis at the early stages of infection. Moreover, the processes associated with particular cell compartments were determined. The ‘omic’ results were subjected to comparative data analyses. Transcriptomic and small RNA (sRNA)–seq data were obtained to provide new insights into PSV-P–satRNA–plant interactions, whereas previously obtained proteomic and phosphoproteomic data were used to broaden the analysis to terms associated with cellular compartments affected by virus infection. Based on the collected results, infection with PSV-P contributed to changes in the abundance of transcripts and proteins associated with various cellular compartments, including ribosomes, chloroplasts, mitochondria, the nucleus and the cytosol, and the most affected processes were photosynthesis, translation, transcription, and mRNA splicing. Furthermore, sRNA-seq and phosphoproteomic analyses indicated that kinase regulation resulted in decreases in phosphorylation levels. The kinases were associated with the membrane, cytoplasm, and nucleus components.
Immiscible silicate liquids: K and Fe distribution as a test for chemical equilibrium and insight into the kinetics of magma unmixing
Authors: Borisov Alexander , Veksler Ilya V. 
Published: May 2021

AbstractSilicate liquid immiscibility leading to formation of mixtures of distinct iron-rich and silica-rich liquids is common in basaltic and andesitic magmas at advanced stages of magma evolution. Experimental modeling of the immiscibility has been hampered by kinetic problems and attainment of chemical equilibrium between immiscible liquids in some experimental studies has been questioned. On the basis of symmetric regular solutions model and regression analysis of experimental data on compositions of immiscible liquid pairs, we show that liquid–liquid distribution of network-modifying elements K and Fe is linked to the distribution of network-forming oxides SiO2, Al2O3 and P2O5 by equation: $$\log K_{{\text{d}}}^{{\text{K/Fe}}} = \, 3.796\Delta X_{{{\text{SiO}}_{2} }}^{{{\text{sf}}}} + \, 4.85\Delta X_{{{\text{Al}}_{2} {\text{O}}_{3} }}^{{{\text{sf}}}} + \, 7.235\Delta X_{{{\text{P}}_{2} {\text{O}}_{5} }}^{{{\text{sf}}}} - \, 0.108,$$

log

K

d

K/Fe

=

3.796
Δ

X

SiO
2

sf

+

4.85
Δ

X

Al
2

O
3

sf

+

7.235
Δ

X

P
2

O
5

sf

-

0.108
,

where $$K_{{\text{d}}}^{{\text{K/Fe}}}$$

K

d

K/Fe

is a ratio of K and Fe mole fractions in the silica-rich (s) and Fe-rich (f) immiscible liquids: $$K_{d}^{{\text{K/Fe}}} = \, \left( {X_{{\text{K}}}^{s} /X_{{\text{K}}}^{f} } \right)/ \, \left( {X_{{{\text{Fe}}}}^{s} /X_{{{\text{Fe}}}}^{f} } \right)$$

K

d

K/Fe

=

X

K

s

/

X

K

f

/

X

Fe

s

/

X

Fe

f

and $$\Delta X_{{\text{i}}}^{sf}$$

Δ

X

i

sf

is a difference in mole fractions of a network-forming oxide i between the liquids (s) and (f): $$\Delta X_{i}^{sf} = X_{i}^{s} - X_{i}^{f}$$

Δ

X

i

sf

=

X

i

s

-

X

i

f

. We use the equation for testing chemical equilibrium in experiments not included in the regression analysis and compositions of natural immiscible melts found as glasses in volcanic rocks. Departures from equilibrium that the test revealed in crystal-rich multiphase experimental products and in natural volcanic rocks imply kinetic competition between liquid–liquid and crystal–liquid element partitioning. Immiscible liquid droplets in volcanic rocks appear to evolve along a metastable trend due to rapid crystallization. Immiscible liquids may be closer to chemical equilibrium in large intrusions where cooling rates are lower and crystals may be spatially separated from liquids.
Laparoscopic complete mesocolic excision with central vascular ligation for splenic flexure colon cancer: short- and long-term outcomes
Authors: Ueda Kazuki , Daito Koji , Ushijima Hokuto , Yane Yoshinori , Yoshioka Yasumasa , Tokoro Tadao , Iwamoto Masayoshi , Wada Toshiaki , Makutani Yusuke , Kawamura Junichiro 
Published: May 2021

Abstract
Background
Complete mesocolic excision (CME) with central vascular ligation (CVL) for colon cancer is an essential procedure for improved oncologic outcomes after surgery. Laparoscopic surgery for splenic flexure colon cancer was recently adopted due to a greater understanding of surgical anatomy and improvements in surgical techniques and innovative surgical devices.

Methods
We retrospectively analyzed the data of patients with splenic flexure colon cancer who underwent laparoscopic CME with CVL at our institution between January 2005 and December 2017.

Results
Forty-five patients (4.8%) were enrolled in this study. Laparoscopic CME with CVL was successfully performed in all patients. The median operative time was 178 min, and the median estimated blood loss was 20 g. Perioperative complications developed in 6 patients (13.3%). The median postoperative hospital stay was 9 days. According to the pathological report, the median number of harvested lymph nodes was 15, and lymph node metastasis developed in 14 patients (31.1%). No metastasis was observed at the root of the middle colic artery or the inferior mesenteric artery. The median follow-up period was 49 months. The cumulative 5-year overall survival and disease-free survival rates were 85.9% and 84.7%, respectively. The cancer-specific survival rate in stage I-III patients was 92.7%. Recurrence was observed in 5 patients (11.1%), including three patients with peritoneal dissemination and two patients with distant metastasis.

Conclusions
Laparoscopic CME with CVL for splenic flexure colon cancer appears to be oncologically safe and feasible based on the short- and long-term outcomes in our study. However, it is careful to introduce this procedure to necessitate the anatomical understandings and surgeon’s skill. The appropriate indications must be established with more case registries because our experience is limited.
Interventions to improve cancer survivorship among Indigenous Peoples and communities: a systematic review with a narrative synthesis
Authors: Gifford Wendy , Rowan Margo , Dick Peggy , Modanloo Shokoufeh , Benoit Maggie , Al Awar Zeina , Wazni Liquaa , Grandpierre Viviane , Thomas Roanne , Sikora Lindsey , Graham Ian D. 
Published: May 2021

Abstract
Purpose
The purpose of this systematic review is to synthesize the evidence on the types of interventions that have been utilized by Indigenous Peoples living with cancer, and report on their relevance to Indigenous communities and how they align with holistic wellness.

Methods
A systematic review with narrative synthesis was conducted.

Results
The search yielded 7995 unique records; 27 studies evaluating 20 interventions were included. The majority of studies were conducted in USA, with five in Australia and one in Peru. Study designs were cross-sectional (n=13); qualitative (n=5); mixed methods (n=4); experimental (n=3); and quasi-experimental (n=2). Relevance to participating Indigenous communities was rated moderate to low. Interventions were diverse in aims, ingredients, and outcomes. Aims involved (1) supporting the healthcare journey, (2) increasing knowledge, (3) providing psychosocial support, and (4) promoting dialogue about cancer. The main ingredients of the interventions were community meetings, patient navigation, arts, and printed/online/audio materials. Participants were predominately female. Eighty-nine percent of studies showed positive influences on the outcomes evaluated. No studies addressed all four dimensions of holistic wellness (physical, mental, social, and spiritual) that are central to Indigenous health in many communities.

Conclusion
Studies we found represented a small number of Indigenous Nations and Peoples and did not meet relevance standards in their reporting of engagement with Indigenous communities. To improve the cancer survivorship journey, we need interventions that are relevant, culturally safe and effective, and honoring the diverse conceptualizations of health and wellness among Indigenous Peoples around the world.
Teleguidance-based remote navigation assistance for visually impaired and blind people—usability and user experience
Authors: Chaudary Babar , Pohjolainen Sami , Aziz Saima , Arhippainen Leena , Pulli Petri 
Published: May 2021

AbstractThis paper reports the development of a specialized teleguidance-based navigation assistance system for the blind and the visually impaired. We present findings from a usability and user experience study conducted with 11 blind and visually impaired participants and a sighted caretaker. Participants sent live video feed of their field of view to the remote caretaker’s terminal from a smartphone camera attached to their chest. The caretaker used this video feed to guide them through indoor and outdoor navigation scenarios using a combination of haptic and voice-based communication. Haptic feedback was provided through vibrating actuators installed in the grip of a Smart Cane. Two haptic methods for directional guidance were tested: (1) two vibrating actuators to guide left and right movement and (2) a single vibrating actuator with differentiating vibration patterns for the same purpose. Users feedback was collected using a meCUE 2.0 standardized questionnaire, interviews, and group discussions. Participants’ perceptions toward the proposed navigation assistance system were positive. Blind participants preferred vibrational guidance with two actuators, while partially blind participants preferred the single actuator method. Familiarity with cane use and age were important factors in the choice of haptic methods by both blind and partially blind users. It was found that smartphone camera provided sufficient field of view for remote assistance; position and angle are nonetheless important considerations. Ultimately, more research is needed to confirm our preliminary findings. We also present an expanded evaluation model developed to carry out further research on assistive systems.
Bank efficiency estimation in China: DEA-RENNA approach
Authors: Antunes Jorge , Hadi-Vencheh Abdollah , Jamshidi Ali , Tan Yong , Wanke Peter 
Published: May 2021

AbstractThe current study proposes a new DEA model to evaluate the efficiency of 39 Chinese commercial banks over the period 2010–2018. The paper also, in the second stage, investigates the inter-relationships between efficiency and some bank-specific variables (i.e. bank profitability, bank size, expenses management, traditional business and non-traditional business) under the Robust Endogenous Neural Network Analysis. The findings suggest that the sample of Chinese banks experiences a consistent increase in the level of bank efficiency up to 2015; the efficiency score is 0.915, after which the efficiency level declines and then experiences a slight volatility, while finally ending up with an efficiency score of 0.746 by the end of 2018. We also find that among different bank ownership types, the state-owned banks have the highest efficiency, the rural commercial banks are found to be least efficient and the foreign banks experience the strongest volatility over the examined period. The second-stage analysis shows that bank size exerts a positive influence on the development of non-traditional banking business and a proactive expense management, bank size and non-traditional businesses have a positive impact on efficiency levels, while bank profitability, traditional businesses and expenses management have negative influences on bank efficiency.