bluuebunny/crossref_metadata_2025_split huggingface dataset:
Channel flow of MHD bingham fluid due to peristalsis with multiple chemical reactions: an application to blood flow through narrow arteries
Authors: Vaidya H. , Rajashekhar C. , Prasad K. V. , Khan S. U. , Mebarek-Oudina F. , Patil A. , Nagathan P. 
Published: January 2021

AbstractThe present analysis emphasizes the effects of variable properties on Bingham fluid under MHD peristaltic transport. Due to the impact of mechanical forces on the applied magnetic field on the conducting fluid, the fluid stream gets altered. These principle targets drug transport and control of blood flow during surgeries; hence the impact of MHD flow with convective and porous boundary conditions is considered. Further, the implications of homogeneous and heterogeneous reactions are analyzed by considering wall properties. The governing equations are turned dimensionless by appropriate similarity transformations. The series solution is obtained for temperature, velocity, and concentration by perturbation method with lubrication approach. The graphical representation of the pertinent parameters on the physiological flow quantities is depicted by applying for MATLAB 2019b program. The obtained results reveal that the rise in the magnetic parameter diminishes the velocity and temperature profiles. Further, the impact of variable viscosity slightly improves the magnitude of the trapped bolus. The homogenous and heterogeneous reaction parameters have a converse effect on the concentration distribution. Moreover, the present investigation finds its applications to perceive the complex rheological functioning of blood flow through narrow arteries.
The Essential Role of Cross-national Research in Assessing Theories of Crime: Illustrations from Modern Control Theory
Authors: Gottfredson Michael R. 
Published: January 2021

AbstractContemporary research from around the world provides a body of consistent findings, making it an indispensable tool for the evaluation of crime theory. To be valid, general theories of crime must now be able to accommodate the results of this cross-national research. Modern Control Theory is used as an illustration for conceptualizing this body of research. Research from three critical areas relevant to general theories of crime are used to illustrate the critical nature of this research: (1) results from self-report surveys of offending and victimization; (2) research on the lack of effectiveness of criminal justice sanctions in affecting rates of crime and interpersonal violence; and (3) prevention research that is focused both on early childhood and on the settings in which much crime occurs. Each is consistent with the expectations of Modern Control Theory (Gottfredson and Hirschi in Modern control theory and the limits of criminal justice, Oxford University Press, New York, 2019) and each demands the attention of any general theory purporting to explain crime and interpersonal violence.
The Amorites and the Bronze Age Near East
Authors: Burke Aaron A. 
Published: January 2021

In this book, Aaron A. Burke explores the evolution of Amorite identity in the Near East from ca. 2500–1500 BC. He sets the emergence of a collective identity for the Amorites, one of the most famous groups in Ancient Near Eastern history, against the backdrop of both Akkadian imperial intervention and declining environmental conditions during this period. Tracing the migration of Amorite refugees from agropastoral communities into nearby regions, he shows how mercenarism in both Mesopotamia and Egypt played a central role in the acquisition of economic and political power between 2100 and 1900 BC. Burke also examines how the establishment of Amorite kingdoms throughout the Near East relied on traditional means of legitimation, and how trade, warfare, and the exchange of personnel contributed to the establishment of an Amorite koiné. Offering a fresh approach to identity at different levels of social hierarchy over time and space, this volume contributes to broader questions related to identity for other ancient societies.
Effects of Solar Illumination and Substorms on Auroral Electrojets Based on CHAMP Observations
Authors: Wang Hui , Lühr Hermann 
Published: January 2021

AbstractWe investigate the effects of solar illumination and the substorm process on the auroral electrojets using CHAMP high‐resolution magnetic field data obtained over a period of 10 years. The eastward electrojet was found to be proportional to the ionospheric conductance induced by solar irradiation over the whole day. More notably, a stronger westward current was detected in times of lower fluxtube‐integrated conductance in both hemispheres. The relative spatial distribution and evolution of the westward electrojet and field‐aligned current (FAC) during the substorm periods were also investigated. The position of the westward current coincided with that of the upward FAC in 2000–2200 magnetic local time (MLT), in keeping with the structure of a westward traveling surge. Furthermore, the upward FAC in the local time sector of the poleward of the westward electrojet was supplied mostly by the remote closure current. The downward FACs in the poleward and upward FACs in the equatorward of the westward electrojet existed in the MLT sectors after 2200 h. Finally, the ratio of the peak intensity of the westward electrojet to that of the meridional Pedersen current, in the 2000–2200 MLT sector increased by about 250%, and the value in the 2200–0200 MLT increased by about 10%–20%. These results provide observational evidence of the increased efficiency of the Cowling channel in the night‐time during substorm periods and contribute to our understanding of the formation mechanism of the auroral electrojet.
A Multiscale Numerical Modeling Investigation on the Significance of Flow Partitioning for the Development of Quartz c‐Axis Fabrics
Authors: Bhandari Ankit , Jiang Dazhi 
Published: January 2021

AbstractQuartz c‐axis fabrics in natural mylonites can vary to such an extent that they apparently give opposite senses of shear in a single thin section. Many hypotheses have been invoked to explain this. Here, we couple our self‐consistent multiscale approach for flow partitioning with the viscoplastic self‐consistent model for c‐axis fabric simulation to investigate quartz c‐axis fabric development. Quartz aggregates are regarded as microscale Eshelby inhomogeneities embedded in a macroscale medium whose effective rheology is represented by a hypothetical homogeneous equivalent medium which is assumed to be rheologically isotropic or has a planar anisotropy. We reproduced the observed quartz c‐axis fabrics. We found that although the microscale flow fields are distinct from one another and from the macroscale flow, the microscale vorticity in every inhomogeneity has the same sense as the macroscale vorticity. This implies that one can use the average of the microscale vorticity axes determined through the crystallographic vorticity axis analysis to obtain the macroscale vorticity axis. However, quartz c‐axis fabrics cannot be used to determine the vorticity number where flow partitioning is significant.
Isoselenocyanates: Synthesis and Their Use for Preparing Selenium-Based Heterocycles
Authors: Bossmann Stefan H. , Neri Raul 
Published: January 2021

AbstractIsoselenocyanates (ISCs) are a class of organoselenium compounds that have been recognized as potential chemotherapeutic and chemopreventative agents against cancer(s) and infectious diseases. ISC compounds are chemically analogous to their isosteric relatives, isothiocyanates (ITCs); however, they possess increased biological activity, such as enhanced cytotoxicity against cancer cells. ISCs not only serve as significant products, but also as precursors and essential intermediates for a variety of organoselenium compounds, such as selenium-containing heterocycles, which are biologically active. While syntheses of ISCs have become less difficult to accomplish, the syntheses of selenium-containing heterocycles are often difficult due to the use of highly toxic selenium reagents. Because of this, ISCs can serve as versatile reagents for the preparation of these heterocycles. In this review, the classical and recent syntheses of ISCs will be discussed, along with notable and recent synthetic work employing ISCs to access novel selenium-containing heterocycles.1	Introduction1.1	Selenium and Health2	Isoselenocyanates2.1	Preparation of Isoselenocyanates3	Selenium-Containing Heterocycles3.1	Notable Synthetic Work3.2	Recent Synthetic Work3.2.1	Synthesis of N-(3-Methyl-4-phenyl-3H-selenazol-2-ylidene)benzamide­ Derivatives3.2.2	Synthesis and X-ray Studies of Diverse Selenourea Derivatives3.2.3	Synthesis of Heteroarene-Fused [1,2,4]Thiadiazoles/Selenadiazoles via Iodine-Promoted [3+2] Oxidative Cyclization3.2.4	2-Amino-1,3-selenazole Derivatives via Base-Promoted Multicomponent Reactions4	Conclusion
Expedient Synthesis and Antibacterial Activity of Tetrahydro-1′H-spiro[indoline-3,4′-quinoline]-3′-carbonitrile Derivatives Using Piperidine as Catalyst
Authors: Lalitha Appaswami , Vinoth Nangagoundan , Vadivel Pullar 
Published: January 2021

AbstractA convenient synthesis of 2′-amino-7′,7′-dimethyl-2,5′-dioxo-1′-(phenylamino)-5′,6′,7′,8′-tetrahydro-1′H-spiro[indoline-3,4′-quinoline]-3′-carbonitrile derivatives has been designed using different substituted isatins, various 5,5-dimethyl-3-(2-phenylhydrazinyl)cyclohex-2-enones (arylhydrazones of dimedone) and malononitrile in ethanol with piperidine as catalyst at room temperature. The structures of the synthesized compounds have been elucidated by various spectroscopic techniques. The selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.
A Homeopathic View of the Influence of Chronic Diseases in the Manifestation of COVID-19
Authors: da Costa Fujino Fernanda Maria Simões , Olandim Ana Amélia Campos Claro , Barnabé Vagner Doja , Coggan Jennifer Anne , Benites Nilson Roberti 
Published: January 2021

AbstractCOVID-19 (coronavirus disease 2019) may present variable symptoms among infected individuals, with chronic disease patients appearing as the group most susceptible to present severe pulmonary infection, while having a higher risk of developing complications from the disease. This study demonstrates the relationship between the manifestation of COVID-19 and the presence of chronic miasmatic disease, based on the works of Samuel Hahnemann. The reaction of the individual who previously presented chronic miasmatic disease, when in contact with the stimulus of the epidemic disease, depends on the type of response that the organism was generating in the face of the pre-existing situation: if it is an intense reaction and greater than that which the stimulus of COVID-19 can generate, this individual will not develop the severe form of the epidemic disease; if the reaction is less than that generated by COVID-19, more intense symptoms may appear. Understanding that the presence of a chronic miasmatic disease interferes with the manifestation of COVID-19, which may have repercussions on other organs, can change how one must act on the treatment, as this can alter the individual's health status.
Bone Morphogenetic Protein in Scaphoid Nonunion: A Systematic Review
Authors: Polmear Michael M. , Anderson Ashley B. , Lanier Paul J. , Orr Justin D. , Nesti Leon J. , Dunn John C. 
Published: January 2021

Abstract
Background Scaphoid nonunion can lead to carpal collapse and osteoarthritis, a painfully debilitating problem. Bone morphogenetic protein (BMP) has been successfully implemented to augment bone healing in other circumstances, but its use in scaphoid nonunion has yielded conflicting results.
Case Description The purpose of this study is to assess the outcomes and complications of scaphoid nonunion treated surgically with BMP.
Literature Review A literature review of all available journal articles citing the use of BMP in scaphoid nonunion surgery from 2002 to 2019 was conducted. We included studies that used BMP as an adjunct to surgical treatment for scaphoid nonunions in both the primary and revision settings with computed tomography determination of union. Demographic information, dose of BMP, tobacco use, outcomes, and complications were recorded. A total of 21 cases were included from four different studies meeting inclusion criteria.
Clinical Relevance The union rates were 90.5% overall, 100% for primary surgeries, and 77.8% for revision surgeries. Five patients (24%) experienced 11 complications, including four cases (19%) of heterotrophic ossification. Use of BMP in scaphoid nonunion surgery resulted in a 90.5% overall union rate but was also associated with complications such as heterotopic ossification. All included studies used BMP to augment bone graft, screw or wire fixation, or a combination of methods. The efficacy of BMP in scaphoid nonunion is unclear, and a sufficiently powered, randomized controlled trial is needed to determine optimal fixation methods, dosing, and morbidity of the use of BMP.
Level of Evidence This is a Level IC, therapeutic interventional study.
Early Retrieval of Spanning Plates Used for Fixation of Complex Fractures of the Distal Radius
Authors: Henry Tyler W. , Tulipan Jacob E. , McEntee Richard M. , Beredjiklian Pedro K. 
Published: January 2021

Abstract
Background Spanning plates are being increasingly used for the treatment of complex fractures of the distal radius. The traditional recommendation is to leave the hardware in place for at least 12 weeks.
Questions/Purpose This study assesses the comparative outcomes of spanning plates removed at or before 10 weeks. We hypothesized that acceptable healing and functional outcomes can be achieved with earlier hardware removal to allow for earlier range of motion, rehabilitation, and return to function.
Patients and Methods All patients treated for a comminuted, intra-articular distal radius fracture with a temporary spanning plate were identified. Outcomes of bridge plates removed before 10 weeks were compared with plates removed after 12 weeks. Twenty patients in the short duration cohort were compared with 40 patients in the long duration cohort.
Results All fractures healed and there were 10 complications (4 short duration, 6 long duration) and 2 reoperations (1 short duration, 1 long duration) in the study population. There were no significant differences in final Quick-DASH scores (27.4 short duration, 20.9 long duration) or radiographic alignment. Mean values for wrist extension and ulnar deviation were significantly worse in the long duration cohort, although these differences are of unclear clinical significance.
Conclusion It may be safe to remove spanning bridge plates earlier than what is traditionally recommended. Plate removal at or before 10 weeks did not detract from healing or radiographic alignment. Prospective investigations assessing the optimal duration of fixation for this technique are needed.
Level of Evidence This is a Level IV study.
Factors associated with virtual care access in older adults: a cross-sectional study
Authors: Liu Laura , Goodarzi Zahra , Jones Aaron , Posno Ron , Straus Sharon E , Watt Jennifer A 
Published: January 2021

Abstract

Background
virtual care has been critical during the COVID-19 pandemic, but there may be inequities in accessing different virtual modalities (i.e. telephone or videoconference).

Objective
to describe patient-specific factors associated with receiving different virtual care modalities.

Design
cross-sectional study.

Setting and Subjects
we reviewed medical records of all patients assessed virtually in the geriatric medicine clinic at St. Michael’s Hospital, Toronto, Canada, between 17 March and 13 July 2020.

Methods
we derived adjusted odds ratios (OR), risk differences (RDs) and marginal and predicted probabilities, with 95% confidence intervals, from a multivariable logistic regression model, which tested the association between having a videoconference assessment (vs. telephone) and patient age, sex, computer ability, education, frailty (Clinical Frailty Scale score), history of cognitive impairment and immigration history; language of assessment and caregiver involvement in assessment.

Results
our study included 330 patients (227 telephone and 103 videoconference assessments). The median population age was 83 (Q1–Q3, 76–88) and 45.2% were male. Frailty (adjusted OR 0.62, 0.45–0.85; adjusted RD −0.08, −0.09 to −0.06) and absence of a caregiver (adjusted OR 0.12, 0.06–0.24; adjusted RD −0.35, −0.43 to −0.26) were associated with lower odds of videoconference assessment. Only 32 of 98 (32.7%) patients who independently use a computer participated in videoconference assessments.

Conclusions
older adults who are frail or lack a caregiver to attend assessments with them may not have equitable access to videoconference-based virtual care. Future research should evaluate interventions that support older adults in accessing videoconference assessments.
Comparison of neonatal outcomes with use of a soybean oil–based injectable lipid emulsion vs a 4-oil emulsion product
Authors: Hudgins Dalton K , Holmes Amy P , Parman Malinda G , Harris J Brock 
Published: January 2021

Abstract

Purpose
Results of a study comparing the safety and efficacy outcomes with use of a soybean oil–based injectable lipid emulsion (SO-ILE) vs a 4-oil alternative product in a neonatal population are presented.

Methods
In an institutional review board–approved, multicenter retrospective review, the medical records of 328 patients who were born at a gestational age of ≤34 weeks, had a birth weight of 500 to 2,000 g, were admitted to one of 2 neonatal intensive care units (NICUs) within a large health system, and received at least 7 days of a parenteral nutrition containing either lipid emulsion product were reviewed: 151 (46%) had received SO-ILE and 177 (54%) had received SMOFlipid (Fresenius Kabi). The primary outcome of the study was a composite of development of cholestasis and development of hypertriglyceridemia. Secondary outcomes included total duration of cholestasis treatment with ursodiol and change in body weight from initiation to completion of lipid emulsion treatment.

Results
The primary outcome of development of cholestasis or hypertriglyceridemia occurred in 14.6% of patients in the SO-ILE group and 18.1% of patients in the SMOFlipid group (P = 0.393). There were no statistically significant differences between the groups in total days of ursodiol treatment or average body weight change during the course of lipid emulsion treatment.

Conclusion
In preterm neonates weighing 500 to 2,000 g, use of SMOFlipid did not significantly reduce the incidence of cholestasis or hypertriglyceridemia relative to the incidence with use of SO-ILE. Further research to validate these results is needed.
Systematic Review and Meta-Analysis of Complications Following Mastectomy and Prosthetic Reconstruction in Patients With and Without Prior Breast Augmentation
Authors: Chicco Maria , Ahmadi Ali R , Cheng Hsu-Tang 
Published: January 2021

Abstract

Background
There is limited evidence available in the literature with regard to the complication profile of mastectomy and immediate prosthetic reconstruction in augmented patients.

Objectives
The aim of this systematic review and meta-analysis was to compare postoperative complications between women with vs without prior augmentation undergoing skin- or nipple-sparing mastectomy and immediate prosthetic reconstruction.

Methods
A systematic search was conducted in February 2020 for studies comparing women with vs without prior augmentation undergoing skin- or nipple-sparing mastectomy and immediate prosthetic reconstruction with documentation of postoperative complications. Outcomes analyzed included early, late, and overall complications. Pooled odds ratios (ORs) with 95% CIs were obtained through meta-analysis.

Results
Our meta-analysis, which included 6 studies comparing 241 breasts with prior augmentation and 1441 without, demonstrated no significant difference between the 2 groups in rates of early (36.7% vs 24.8%: OR, 1.57; 95% CI, 0.94-2.64; P = 0.09), late (10.1% vs 19.9%: OR, 0.53; 95% CI, 0.06-4.89; P = 0.57), and overall complications (36.5% vs 31.2%: OR, 1.23; 95% CI, 0.76-2.00; P = 0.40). Subgroup analysis showed a significantly higher rate of hematoma formation in the augmented group (3.39% vs 2.15%: OR, 2.68; 95% CI, 1.00-7.16; P = 0.05), but no difference in rates of seroma, infection, mastectomy skin flap necrosis, and prosthesis loss.

Conclusions
Our meta-analysis suggests that prior augmentation does not significantly increase overall postoperative complications in women undergoing skin- or nipple-sparing mastectomy and immediate prosthetic reconstruction. However, the significantly higher rate of hematoma formation in augmented patients warrants further investigation and preoperative discussion.

Level of Evidence: 3
Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients
Authors: Taz Tasnimul Alam , Ahmed Kawsar , Paul Bikash Kumar , Al-Zahrani Fahad Ahmed , Mahmud S M Hasan , Moni Mohammad Ali 
Published: January 2021

AbstractThis study aimed to identify significant gene expression profiles of the human lung epithelial cells caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We performed a comparative genomic analysis to show genomic observations between SARS-CoV and SARS-CoV-2. A phylogenetic tree has been carried for genomic analysis that confirmed the genomic variance between SARS-CoV and SARS-CoV-2. Transcriptomic analyses have been performed for SARS-CoV-2 infection responses and pulmonary arterial hypertension (PAH) patients’ lungs as a number of patients have been identified who faced PAH after being diagnosed with coronavirus disease 2019 (COVID-19). Gene expression profiling showed significant expression levels for SARS-CoV-2 infection responses to human lung epithelial cells and PAH lungs as well. Differentially expressed genes identification and integration showed concordant genes (SAA2, S100A9, S100A8, SAA1, S100A12 and EDN1) for both SARS-CoV-2 and PAH samples, including S100A9 and S100A8 genes that showed significant interaction in the protein–protein interactions network. Extensive analyses of gene ontology and signaling pathways identification provided evidence of inflammatory responses regarding SARS-CoV-2 infections. The altered signaling and ontology pathways that have emerged from this research may influence the development of effective drugs, especially for the people with preexisting conditions. Identification of regulatory biomolecules revealed the presence of active promoter gene of SARS-CoV-2 in Transferrin-micro Ribonucleic acid (TF-miRNA) co-regulatory network. Predictive drug analyses provided concordant drug compounds that are associated with SARS-CoV-2 infection responses and PAH lung samples, and these compounds showed significant immune response against the RNA viruses like SARS-CoV-2, which is beneficial in therapeutic development in the COVID-19 pandemic.