bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Effects of Gamification and Teach-Back Training Methods on Adherence to a Therapeutic Regimen in Patients After Coronary Artery Bypass Graft Surgery: Randomized Clinical Trial
Authors: Ghorbani Banafsheh , Jackson Alun C , Noorchenarboo Mohammad , Mandegar Mohammad H , Sharifi Farshad , Mirmoghtadaie Zohrehsadat , Bahramnezhad Fatemeh 
Published: December 2021

Background
Patients undergoing coronary artery bypass graft surgery (CABGS) may fail to adhere to their treatment regimen for many reasons. Among these, one of the most important reasons for nonadherence is the inadequate training of such patients or training using inappropriate methods.

Objective
This study aimed to compare the effect of gamification and teach-back training methods on adherence to a therapeutic regimen in patients after CABGS.

Methods
This randomized clinical trial was conducted on 123 patients undergoing CABGS in Tehran, Iran, in 2019. Training was provided to the teach-back group individually. In the gamification group, an app developed for the purpose was installed on each patient’s smartphone, with training given via this device. The control group received usual care, or routine training. Adherence to the therapeutic regimen was assessed using a questionnaire on adherence to a therapeutic regimen (physical activity and dietary regimen) and an adherence scale as a pretest and a 1-month posttest.

Results
One-way analysis of variance (ANOVA) for comparing the mean scores of teach-back and gamification training methods showed that the mean normalized scores for the dietary regimen (P<.001, F=71.80), movement regimen (P<.001, F=124.53), and medication regimen (P<.001, F=9.66) before and after intervention were significantly different between the teach-back, gamification, and control groups. In addition, the results of the Dunnett test showed that the teach-back and gamification groups were significantly different from the control group in all three treatment regimen methods. There was no statistically significant difference in adherence to the therapeutic regimen between the teach-back and control groups.

Conclusions
Based on the results of this study, the use of teach-back and gamification training approaches may be suggested for patients after CABGS to facilitate adherence to the therapeutic regimen.

Trial Registration
Iranian Registry of Clinical Trials IRCT20111203008286N8; https://en.irct.ir/trial/41507
Are We Missing Something? The Skin Lesions Not Seen in Teledermatology
Authors: Jones Leah , Oakley Amanda 
Published: December 2021

Background
The suspected skin cancer electronic referral pathway was introduced in 2017. It requires general practitioners to add regional, close-up, and dermoscopic images to a lesion-specific referral template for a teledermatologist to review and advise on management. The virtual lesion clinic is a nurse-led clinic used since 2010 to obtain high-quality images for teledermoscopy assessment. A limitation of both services is the absence of a full-body examination.

Objective
This study aims to evaluate the number of skin cancers missed during teledermatology assessment.

Methods
This is a retrospective review of skin lesion referrals to dermatology. Suspected skin cancer referrals made in the latter half of 2020 were compared with referrals to the virtual lesion clinic during a similar time period in 2016.

Results
The study included 481 patients with 548 lesions in the 2020 suspected skin cancer cohort that were matched for age, sex, and ethnicity to 400 patients with 682 lesions in the 2016 virtual lesion clinic cohort. A total of 41 patients underwent subsequent specialist review in the suspected skin cancer cohort compared to 91 in the virtual lesion clinic cohort. A total of 20% of the suspected skin cancer cohort and 24% of the virtual lesion clinic cohort were found to have at least one additional lesion of concern. The majority of these were keratinocytic skin cancers; there were 2 and 0 additional melanomas or melanoma-in-situ, respectively. The virtual lesion clinic nurses identified additional lesions for imaging in 78 of 400 (20%) patients assessed in the virtual lesion clinic. The teledermatologist determined (author AO) that 73% of these additional lesions were malignant. Of the 548 lesions, 10 (2%) in the suspected skin cancer group were rereferred, none of which had a change in diagnosis. Out of 682 lesions, 16 (2%) in the virtual lesion clinic cohort were rereferred, 6 (1%) of which had a change in diagnosis.

Conclusions
Patients diagnosed with skin cancer often have multiple lesions of concern. Single-lesion teledermoscopy diagnoses have high concordance with in-person evaluation and histology; however, we have shown that in-person examination may reveal other suspicious lesions. The importance of a full-body skin examination should be emphasized to the referrer.

Acknowledgments
The Waikato Medical Research Foundation provided financial support for the study.

Conflicts of Interest
None declared.
Risk of arterial hypertension development due to T393C gene polymorphism of α-subunit of G-protein
Authors: I. A. Dudсhenko  
Published: December 2021

According to foreign researchers, T393С gene polymorphism of α-subunit of the G-protein (rs7121) affects the sympathetic-adrenal system and the risk of hypertension. There are also data on the dependence of the manifestations of this polymorphism on the associated risk factors. However, these data are contradictory, which may be explained by ethnic differences in patients. In Ukraine there were no studies on this issue. We have studied 166 hypertensive patients and 90 healthy individuals. Determination of the polymorphism was performed by polymerase chain reaction with subsequent analysis of restriction fragments. The study found no statistically significant difference in the distribution of genotypes T393T, T393С, С393С in patients with hypertension and healthy subjects (p>0,05). The risk for hypertension in carriers of genotypes T393T + T393С relatively to С393С genotype was not significantly different (OR=1,44, 95% CI 0,74-2,80; p=0,283). During the analysis of the effect of smoking on the manifestations of T393С gene polymorphism α-subunit of the G-protein, no statistically significant difference were found (p>0,05). T393C gene polymorphism of α-subunit of G-protein did not affect the risk of hypertension.
Hormonal adaptation of the fetal-placental complex in women with preeclamsia
Authors: S. Y. Kosilova  
Published: December 2021

The course of pregnancy and labour in women with preeclampsia considerably determines maternal and perinatal morbidity and mortality. The study of the hormonal function of the fetal-placental complex appears to be rather topical in this respect. The research conducted gave the evidence that the pregnant with preeclampsia develop placental dysfunction. It results in a decrease of hormone production in the fetal-placental complex, development of complications during gestation, labour, conditions of the fetus, and requires a hormone-correcting therapy.
Past, present and future of medical biology department of Bukovinian state medical university (on the occasion of 70th anniversary of the department)
Authors: V. P. Pishak  , R. Y. Bulyk  , O. I. Zakharchuk  , N. V. Chernovska  
Published: December 2021

The work of Medical Biology Department of Bukovinian State Medical University over 70 years has been analysed. General directions of teaching, researching and educational work at the junction of two centuries have been characterised.
The influence of melatonin on the state of the glutathione system of the rat liver under the conditions of subacute alcoholic intoxication
Authors: N. V. Davydova  
Published: December 2021

The investigations of certain parameters of glutathione system in the liver of rats under the conditions of subacute alcohol intoxication revealed a decreased content of reduced glutathione and glutathione peroxidase activity as well as an activation of glutathione-S-transferase activity. An oral administration of “Vita-melatonin” against a background of subacute alcohol intoxication in a dose 5 mg/kg during 10 days prevented the changes of the parameters under study.
Dynamics of hematogenous dissemination of intestinal microflora in experimental acute destructive pancreatitis
Authors: D. V. Rotar  
Published: December 2021

The results of microbiological examination of haematogenous dissemination of intestinal microflora in the dynamics of experimental acute destructive pancreatitis are presented in the article. The species composition and population levels of contaminants have been determined. Based on the experimental study, contamination of portal blood within 24-48 hours of opportunistic enterobacteria and staphylococci in high and low systemic blood at the population level has been established.
Features of trichomoniasis treatment in postpartum period
Authors: A. V. Semenyak  
Published: December 2021

A clinical and laboratory examination of women with single fever over 38° and treatment of trichomoniasis has been performed. Parturients of the main group were divided into 3 groups: I group – 10 women who refused to be treated, II group – 10 women who used topical treatment with metronidazole , III group – 40 women who agreed to the proposed treatment (100 ml metronidazole (0,5 g ) three times a day (or ornihil 100 ml (0,5 g ) twice a day), 0,2 grams of fluoroquinolones, cephalosporins 1,0 g twice a day) right after being diagnosed. The dynamics was only positive in the parturients of the hird subgroup, the treatment was effective too; the average length of stay in hospital was 4-5 days.
Treatment efficiency of subclinical atherosclerosis according to ultrasound scan of the heart and vessels and to the stress tests
Authors: V. K. Tashchuk  , O. M. Hinhuliak  , P. R. Ivanchuk  
Published: December 2021

In order to investigate the efficiency of a statin therapy (group 1, atorvastatin) and metabolic treatment (group 2, trimetazidine and MagneB6) 164 patients with signs of subclinical atherosclerosis were examined depending on an increase of intima-media thickness more than 0.9 mm in conditions of the pair echocardiography and stress tests (treadmill) with long follow-up observation (3 months and 1 year). Evaluation of the remodeling process in both treatment groups (statin/metabolic therapy) indicates a tendency, after 3 months of treatment, to increase the number of cases withincreased ejection fraction (EF) in group 1 (p<0,05) in unreliable predominance of cases not altered EF in group 2 (p>0,1) with the increase in the incidence of concentric remodeling of the left ventricle twice as often in group 2 (p>0,05), three times – in 3 months (p>0,5) after 1 year (p<0,05). The increase in exercise tolerance was registered in group 1 during the treatment period of 3 months (p<0,05) and 1 year (p<0,01) in contrast to group 2 with no changes in rate for 3 months (p>0,5) with an increase after 1 year (p<0,05). Thus, the differences in influence of statin therapy and metabolic treatment on the parameters of central haemodynamics and response to stress tests for subclinical atherosclerosis have been established.
Analysis of operative interventions in patients of Chernivtsi region with thyroid gland pathology
Authors: V. V. Bilookyi  , N. P. Tkachuk  , M. I. Sheremet  , Y. V. Hyrla  
Published: December 2021

We have found out that thyroid pathology has tended to increase in Chernivtsi region during the last five years. Among the operative interventions in patients with thyroid gland pathologies, thyreoidectomies and subtotal resections of the organ tended to increase. Endemia in Chernivtsi region is moderate with Lenz Bauer index (relation of male and female patients) being 1:9.
Influence of periodontal disorders on general well being of the body. The modern methods of pharmacological treatment of apical periodontitis in permanent teeth, advantages and disadvantages (review of the references)
Authors: I. R. Kostiuk  
Published: December 2021

The article demonstrates the analysis of the data regarding the affect of odontogenic local infection caused by apical periodontitis on the general well being of the body. We have investigated the current local and general management of periodontal disorders with indication of their advantages and disadvantages. We also explain the need of complex treatment of acute apical chronic periodontitis and its exacerbation in permanent teeth in children and the requirements in herbal pharmacological agents in treatment of periodontal disorders.
A glance on a problem of comorbid conditions touched upon in the national agreement on treatment and diagnostics of COPD from the viewpoint of personal experience. Disccussion over decree no.555
Authors: Y. M. Mostovoy  , L. V. Rasputina  , A. O. Dovgan  , M. V. Ovcharuk  
Published: December 2021

The purpose of the study was to analyze the prevalence of comorbid pathologies in patients with chronic obstructive pulmonary disease (COPD) and the effect of comorbidity on the course of disease in the light of existing recommendations on supervision of COPD patients and from the standpoint of our own experience. We made an analysis of prevalence of arterial hypertension, coronary heart disease, diabetes mellitus, and psychosomatic disorders in patients with COPD. The analysis of the world data revealed that comorbidity in patients with COPD was diagnosed much less frequently, which may be preconditioned with the problems of under-diagnosis for COPD itself. At the same time, patients with comorbid conditions were diagnosed a number of serious clinical syndromes that predetermined the course and severity of the disease. Administration of beta-blockers to patients with COPD is effective and safe and may positively influence the prognosis for those patients.
Modern innovative technologies as ways to improve the educational process in specialty "Surgery"
Authors: V. M. Haliuk  
Published: December 2021

The experience of Ivano-Frankivsk National Medical University Department of Surgery №1 in innovative technologies implementation and improvement of interactive teaching methods at all stages of the students’ learning process while studying specialty at medical faculty is presented. At the stage of determining the final level of knowledge we use testing, case-tasks, gaming and non-gaming techniques of simulated training are used, and the quality of the knowledge is assessed by means of a module control.
The modern view of the contact of body pedestrian with cars wheel in case of accident
Authors: Plevynskys Pavlo 
Published: December 2021

Therefore, the aim of this study − was to perform what specific variants of human injury wheel of a moving vehicle is encountered in the modern practice of forensic expertise than they are, and how they can be classified on the basis of the practical needs of a forensic medical expert.
Material and methods: To achieve the research objectives investigated the circumstances of the receipt and morphology of injuries in casualties in the case of contact of a body with wheels of a vehicle, (71 during the period from 2010 to 2015, according to the materials of the Odessa regional Bureau of a forensic medical examination).Conclusions:1. Rolling a wheel of the vehicle through the body of the victim can take place not only in finding the victim lying on the roadway, but subject to finding it in a vertical or close to it position. While injured, as a rule, the foot feet of the victim.2. In addition to the rolling wheel through the lower limb of the victim can take place still at least 2 options of injury to the victim the wheel of a car:− as a result of contact of the tibia of the injured between the moving wheel and the wheel arch of the vehicle;− as a result of hitting the wheel of a car at the lower extremities of the victim. Such an attack can be combined withfriction of the extremities of the wheel of the vehicle and not be accompanied by compression of the limb between the rotatingwheel and other subjects (especially the road surface).3. It seems that this type of car injury better not be called «moving wheel» and injury as a result of human contact with the wheel (wheels) of the vehicle.
The Relationship between Transformational Leadership Practiced and the Level of Job Satisfaction among Lecturers in MARA Professional College, Malaysia
Authors: Mahzan Fareez Ashraf , Mohd. Nordin Norazah 
Published: December 2021

Abstract: The quality and level of job satisfaction among lecturers play a significant role in implementing transformation to improve the education system. The main reason for the decreasing of job performances among lecturers is due to the low level of job satisfaction. This study aimed to examine the relationship between a director’s transformational leadership style and the level of job satisfaction among lecturers at MARA Professional College. This is a survey study employing descriptive and inferential quantitative method. The Multifactor Leadership Questionnaire (MLQ) and Job Descriptive Index (JDI) instruments were distributed to 64 participants that were chosen using simple random sampling from the 75 population of MARA Professional College lecturers. The data was analyzed using Statistical Package for Social Science (SPSS) version 22. The findings revealed that the level of practice of the director on transformational leadership was low. In addition, there was a significant relationship between the transformational leadership practice of the director and the level of job satisfaction among lecturers at MARA Professional College. The level of job satisfaction among the lecturers was influenced by the director’s leadership practice, thus a director can increase the level of job satisfaction among the staff by practicing the transformational leadership style in managing a college. The findings are expected to assist the organization of MARA Professional College to identify the level of work pressure faced by the lecturers.

Keywords: Job Satisfaction, Higher Education, Transformational Leadership
Exploring Movies for Language Teaching and Learning at the Tertiary Level
Authors: Roslim Norwati , Azizul Aini Faridah , Nimehchisalem Vahid , Tew Abdullah Muhammad Hakimi 
Published: December 2021

Abstract: The increasing importance of using movies to enhance second language teaching and learning has been addressed by researchers and educators. A few scholarly studies have effortlessly put forward significant findings on using movies in the area of theoretical bases, pedagogical aspects and learners’ perspectives. However, more studies need to be explored further as proposed by many scholars in their suggested future research. Hence, this study aims to investigate perceptions and experiences among university undergraduate students in exploring English language movies of their own choice for their oral commentary presentations. A corpus of English movies selected by students was used to assist students in their presentations. A total of 77 university undergraduates took part in the study. The data was collected through an online survey which consisted of a three-section questionnaire: demographic profile, learners’ perceptions and learners’ experiences. The data were analysed descriptively using SPSS version 20. The results revealed that using movies has helped students mainly, in improving their oral skills, vocabulary, interest and motivation as well as decreasing their anxiety and tension. This study adds to the body of knowledge and benefits educators and instructors on using movies for language teaching and learning.

Keywords: Experiences, Language Learning, Movies, Perceptions
Motivational Orientations of Learning Japanese as A Foreign Language Among Undergraduates In A Public University In Malaysia
Authors: Maktiar Singh Kuldip Kaur , Loh Er Fu David , Leong Yoke Chu Irene , Yook Ngor Phang , Yann Seng Chan , Abd Hamid Nurul Atiqah 
Published: December 2021

Abstract: Motivation is a key factor in learning a foreign language. This study investigated the instrumental, integrative and attitudinal motivation level of students learning Japanese as a FL in a public university in Malaysia. A survey questionnaire based on Gardner’s (1985) AMTB (Attitude/Motivation Test Battery) and Dornyei’s (1994) Attitudinal Motivation was given to 171 undergraduates. Descriptive and Inferential statistics were used to analyse the data. The results of the study indicated that the foreign language learners were generally highly motivated to learn Japanese as a foreign language. Moreover, their integrative and attitudinal motivational levels were similarly high and slightly higher than their instrumental motivation. There were also statistically significant differences among the three subscales of attitudinal motivation viz. teacher-specific, course-specific and group-specific. They were more oriented towards teacher-specific and course-specific attitudinal motivation than group-specific attitudinal motivation. The implications for EFL teachers and curriculum developers are that it would improve foreign language learning courses in future by designing suitable lessons and preparing appropriate materials and activities.
Keywords: Attitude, Foreign language learning, Instrumental orientation, Integrative orientations, Motivation
Evaluation of Computational Approaches of Short Weierstrass Elliptic Curves for Cryptography
Authors: Abhishek Kunal , Raj E. George Dharma Prakash 
Published: December 2021

Abstract
The survey presents the evolution of Short Weierstrass elliptic curves after their introduction in cryptography. Subsequently, this evolution resulted in the establishment of present elliptic curve computational standards. We discuss the chronology of attacks on Elliptic Curve Discrete Logarithm Problem (ECDLP) and investigate their countermeasures to highlight the evolved selection criteria of cryptographically safe elliptic curves. Further, two popular deterministic and random approaches for selection of Short Weierstrass elliptic curve for cryptography are evaluated from computational, security and trust perspectives and a trend in existent computational standards is demonstrated. Finally, standard and non-standard elliptic curves are analysed to add a new insight into their usability. There is no such survey conducted in past to the best of our knowledge.
Therapeutic Potential of „Derived-Multiple Allogeneic Proteins Paracrine Signaling-D-Mapps” in the Treatment of Dry Eye Disease
Authors: Harrell Carl Randall , Fellabaum Crissy , Miloradovic Dragica , Acovic Aleksandar , Miloradovic Dragana , Markovic Bojana Simovic , Arsenijevic Nebojsa , Karpecki Paul , Volarevic Vladislav 
Published: December 2021

Abstract
Dry eye disease (DED) is a chronic inflammatory disease of the lacrimal system and ocular surface. Considering the important role of inflammation in DED development, the main treatment strategy has shifted from hydration and lubrication of dry ocular surface to the immunomodulation and immunoregulationapproach that should address the main pathologic processes responsible for disease progression. Due to their capacity for production of immunosuppressive factors, mesenchymal stem cells (MSCs) and their secretome have been considered as potentially new agents in DED therapy. We recently developed an immunomodulatory ophthalmic solution “derived- Multiple Allogeneic Proteins Paracrine Signaling (d-MAPPS)” which activity is relied on immunosuppressive capacity of MSC-derived secretome. d-MAPPS contains MSC-derived exosomes, growth factors and immunosuppressive cytokines that are able to efficiently suppress generation of inflammatory phenotype in T cells and macrophages. Herewith, we demonstrated that d-MAPPS protected human corneal epithelial cells from chemical injury and efficiently alleviated ocular discomfort and pain in 131 DED patients during the 12-month follow-up, indicating d-MAPPS eye drops as potentially new remedy for the treatment of DED patients.