bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Distinct Therapies on Antibody Response to SARS‐CoV‐2 Vaccine in Systemic Lupus Erythematosus
Authors: Yuki Emily F. N. , Borba Eduardo F. , Pasoto Sandra G. , Seguro Luciana P. , Lopes Michelle , Saad Carla G. S. , Medeiros‐Ribeiro Ana Cristina , Silva Clovis A. , de Andrade Danieli C. O. , Kupa Leonard de Vinci K. , Betancourt Lorena , Bertoglio Isabela , Valim Juliana , Hoff Camilla , Formiga Francisco F. C. , Pedrosa Tatiana , Kallas Esper G. , Aikawa Nadia E. , Bonfa Eloisa 
Published: November 2021

ObjectiveTo date, the only study that has assessed the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 mRNA) vaccine in systemic lupus erythematosus (SLE) observed a moderate response, but the sample size precluded an accurate analysis of the effect of individual drugs. Therefore, we evaluated the immunogenicity of an inactivated SARS‐CoV‐2 vaccine (Sinovac‐CoronaVac) and the influence of different medications in SLE. Safety was also assessed.MethodsWe conducted a prospective controlled study of 232 SARS‐CoV‐2–naive SLE patients and 58 SARS‐CoV‐2–naive controls who were vaccinated with 2 doses of Sinovac‐CoronaVac with a 28‐day interval (day 0/day 28 [D0/D28]). Immunogenicity analysis at D0/D28 and D69 included anti‐SARS‐CoV‐2 S1/S2 IgG seroconversion (SC) and neutralizing antibodies (NAb) positivity. The influence of individual drugs on immune response and safety was assessed.ResultsPatients and controls were well balanced for age (P = 0.771). At D69, SLE patients showed a moderate SC (70.2% versus 98.1%; P < 0.001) and moderate frequency of NAb positivity (61.5% versus 84.6%; P = 0.002), although both frequencies were lower than in controls. Factors associated with lower SC in univariate analysis at D69 were prednisone use (odds ratio [OR] 0.215 [95% confidence interval (95% CI) 0.108–0.427], P < 0.001) and mycophenolate mofetil (MMF) use (OR 0.201 [95% CI 0.107–0.378], P < 0.001), whereas hydroxychloroquine (HCQ) use led to a 2.5 increase in SC (P = 0.011). SLE patients who were receiving HCQ monotherapy had similar SC to controls at D69 (100% versus 98.1%; P = 1.000). In multivariate analysis, prednisone and MMF use were independently associated with lower SC (P < 0.001) and NAb positivity (P < 0.001). Safety analysis revealed no moderate/severe adverse events.ConclusionSinovac‐CoronaVac has a moderate immunogenicity in SARS‐CoV‐2–naive SLE patients with an excellent safety profile. We further demonstrate that HCQ may improve SC, whereas prednisone and MMF had a major deleterious effect in vaccine response, reinforcing the need to investigate the role of temporary MMF withdrawal or a vaccine‐booster dose (ClinicalTrials.gov identifier: NCT04754698).
In‐situ Investigations on Gold Nanoparticles Stabilization Mechanisms in Biological Environments Containing HSA
Authors: Iranpour Anaraki Neda , Liebi Marianne , Ong Quy , Blanchet Clément , Maurya Anjani K. , Stellacci Francesco , Salentinig Stefan , Wick Peter , Neels Antonia 
Published: November 2021

AbstractNanoparticles (NPs) developments advance innovative biomedical applications. However, complex interactions and the low colloidal stability of NPs in biological media restrict their widespread utilization. The influence of NPs properties on the colloidal stability for gold NPs with 5 and 40 nm in diameter with two surface modifications, methoxy‐polyethylene glycol‐sulfhydryl (PEG) and citrate, in NaCl and human serum albumin (HSA) protein solution, is investigated. This study is based on small‐angle X‐ray scattering (SAXS) methods allowing the in‐situ monitoring of interactions in physiological conditions. The PEG coating provides high colloidal stability for NPs of both sizes. For 5 nm NPs in NaCl solution, a stable 3D self‐assembled body‐centered cubic (BCC) arrangement is detected with an interparticle distance of 20.7 ± 0.1 nm. In protein solution, this distance increases to 21.9 ± 0.1 nm by protein penetration inside the ordered structure. For citrate‐capped NPs, a different mechanism is observed. The protein particles attach to the NPs surfaces, and an appropriate concentration of proteins results in a stable suspension. Cryogenic transmission electron microscopy (Cryo‐TEM), UV–visible spectroscopy, and dynamic light scattering (DLS) support the SAXS results. The findings will pave the way to design and synthesize NPs with controlled behaviors in biomedical applications.
Scalable Polyimide‐Poly(Amic Acid) Copolymer Based Nanocomposites for High‐Temperature Capacitive Energy Storage
Authors: Dai Zhizhan , Bao Zhiwei , Ding Song , Liu Chuanchuan , Sun Haoyang , Wang He , Zhou Xiang , Wang Yuchen , Yin Yuewei , Li Xiaoguang 
Published: November 2021

AbstractThe developments of next‐generation electric power systems and electronics demand for high temperature (≈150 °C), high energy density, high efficiency, scalable, and low‐cost polymer‐based dielectric capacitors are still scarce. Here, the nanocomposites based on polyimide‐poly(amic acid) copolymers with a very low amount of boron nitride nanosheets are designed and synthesized. Under the actual working condition in hybrid electric vehicles of 200 MV m−1 and 150 °C, a high energy density of 1.38 J cm−3 with an efficiency higher than 96% is achieved. This is about 2.5 times higher than the room temperature energy density (≈0.39 J cm−3 under 200 MV m−1) of the commercially used biaxially oriented polypropylene, the benchmark of dielectric polymer. Especially, the energy density and efficiency at 150 °C show no sign of degradation after 20 000 cycles of charge‐discharge test and 35 days’ high‐temperature endurance test. This research provides an effective and low‐cost strategy to develop high‐temperature polymer‐based capacitors.
Highly Efficient Blue Phosphorescence from Pillar‐Layer MOFs by Ligand Functionalization
Authors: Liu Haohao , Ye Wenpeng , Mu Ying , Ma Huili , Lv Anqi , Han Songde , Shi Huifang , Li Jinhua , An Zhongfu , Wang Guoming , Huang Wei 
Published: November 2021

AbstractRoom temperature phosphorescence (RTP) has been extensively researched in heavy‐metal containing complexes and purely organic systems. Despite the rapid blossom of RTP materials, it is still a tremendous challenge to develop highly efficient blue RTP materials with long‐lived lifetimes. Taking the metal–organic framework (MOF) as a model, herein, a feasible strategy of ligand functionalization is proposed, including two essential elements, to develop blue phosphorescence materials with high efficiency and long‐lived lifetimes simultaneously under ambient conditions. One is isolation of the chromophores with assistance of another predefined co‐ligands, the other is restriction of the chromophores’ motions through coordination and host‐guest interactions. Remarkably, it renders the MOFs with highly efficient blue phosphorescence up to 80.6% and a lifetime of 169.7 ms under ambient conditions. Moreover, a demo of the crown is fabricated with MOFs ink by 3D printing technique. The potential applications for anti‐counterfeiting and fingerprint visualization have been also demonstrated. This finding not only outlines a universal principle to design and synthesize highly efficient RTP materials, but also endows traditional MOFs with fresh vitality for potential applications.
Hybrid Perovskite Degradation from an Optical Perspective: A Spectroscopic Ellipsometry Study from the Deep Ultraviolet to the Middle Infrared
Authors: Tejada Alvaro , Peters Sven , Al‐Ashouri Amran , Turren‐Cruz Silver Hamill , Abate Antonio , Albrecht Steve , Ruske Florian , Rech Bernd , Guerra Jorge Andrés , Korte Lars 
Published: November 2021

AbstractA quantitative analysis of the thermally induced degradation of various device‐relevant multi‐cation hybrid perovskite films is performed using spectroscopic ellipsometry, for temperatures between 80 and 120 °C. The studied compositions are a triple cation perovskite Cs0.05(MA0.17FA0.83)0.95Pb(Br0.17I0.83)3, a Rb‐containing variant Rb0.05Cs0.05(MA0.17FA0.83)0.90Pb(Br0.17I0.83)3, and a methylammonium‐free Rb0.05Cs0.10FA0.85PbI3 composition. A very wide combined spectral range of 200 nm to 25 μm is covered by combining the data from two separate instruments. The relative changes in organic cation concentrations are quantified from the middle infrared molecular absorption bands, leveraging the use of point‐by‐point fitting for increased sensitivity. Additionally, the formation of PbI2 and non‐perovskite δ‐CsPbI3 phases is evidenced from Bruggemann effective medium fits to the visible and ultraviolet complex refractive indices. Methylammonium is almost completely depleted from the relevant compositions within 100 to 285 min of thermal annealing. The MA‐free perovskite degrades faster at intermediate temperatures, which is attributed to phase instability due to the formation of δ‐CsPbI3 in addition to PbI2.
Retainable Bandgap Narrowing and Enhanced Photoluminescence in Mn‐Doped and Undoped Cs2NaBiCl6 Double Perovskites by Pressure Engineering
Authors: Zhang Long , Liu Zhengtao , Sun Xuening , Niu Guangming , Jiang Jutao , Fang Yuanyuan , Duan Defang , Wang Kai , Sui Laizhi , Yuan Kaijun , Wu Guorong , Zou Bo 
Published: November 2021

AbstractPressure engineering can access novel optoelectronic properties and crystal structures in halide perovskite materials with soft lattice. However, such pressure‐induced phenomena are commonly realized under large pressure or difficult to retain at atmospheric pressure, thus severely hindering their prospects in practical applications. Herein, the pressure‐treated Mn‐doped/undoped Cs2NaBiCl6 exhibits a largely retained bandgap narrowing of 12.2% relative to its initial state via compression–decompression cycles, along with durable stability at ambient conditions. This abnormal behavior is attributed to the disordered arrangement of inorganic [NaCl6]5−/[BiCl6]3− octahedra, which occurs in the metastable state of double perovskites from structural reconstruction during decompression processes, and is accompanied by a characteristic of long‐range order and short‐range disorder. A remarkable pressure‐induced emission enhancement from Mn2+ ions is discovered upon modest compression, especially at <0.5 GPa, which results from the increased energy transfer efficiency from Bi3+ to Mn2+ ions owing to more overlapped electronic wave functions from each other. This work can be extended to the design and synthesis of new semiconductor materials with enhanced optoelectronic properties.
Directed Regeneration of Osteochondral Tissue by Hierarchical Assembly of Spatially Organized Composite Spheroids
Authors: Lee Jinkyu , Lee Seoyun , Huh Seung Jae , Kang Byung‐Jae , Shin Heungsoo 
Published: November 2021

AbstractThe use of engineered scaffolds or stem cells is investigated widely in the repair of injured musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral tissue remains a challenge due to delamination between cartilage and subchondral bone or difficulty in spatial control over differentiation of transplanted stem cells. Here, two types of composite spheroids are prepared using adipose‐derived stem cells (hADSCs) and nanofibers coated with either transforming growth factor‐β3 or bone morphogenetic growth factor‐2 for chondrogenesis or osteogenesis, respectively. Each type of spheroid is then cultured within a 3D‐printed microchamber in a spatially arranged manner to recapitulate the bilayer structure of osteochondral tissue. The presence of inductive factors regionally modulates in vitro chondrogenic or osteogenic differentiation of hADSCs within the biphasic construct without dedifferentiation. Furthermore, hADSCs from each spheroid proliferate and sprout and successfully connect the two layers mimicking the osteochondral interface without apertures. In vivo transplantation of the biphasic construct onto a femoral trochlear groove defect in rabbit knee joint results in 21.2 ± 2.8% subchondral bone volume/total volume and a cartilage score of 25.0 ± 3.7. The present approach can be an effective therapeutic platform to engineer complex tissue.
Let's talk teaching: Progressive pedagogy in anthropology courses
Authors: Kissel Marc , Blum Susan D. 
Published: November 2021

AbstractObjectivesIn this article, we discuss research from the science of teaching and learning and from progressive pedagogy, with the aim of discussing how these fields can help us all become better teachers.MethodsOur methods were based on assessment of the literature and our in‐class practices.ResultsWe find that the practices of critical progressive pedagogy are rooted in good research practices and are based both on new research and on fundamental aspects of teaching and learning.ConclusionsWhile some of the ideas mentioned in this piece might be seen as radical, we argue that everyone can benefit from a discussion of these concepts and ideas. Teaching is something that we all do in various ways. Progressive pedagogy allows us to create classrooms as a space to welcome all learners and also pushes educators toward creating a more diverse, inclusive, and equitable classroom.
Sanfilippo syndrome type B: Analysis of patients diagnosed by the MPS Brazil Network
Authors: Montenegro Yorran Hardman Araújo , de Souza Carolina Fischinger Moura , Kubaski Francyne , Trapp Franciele Barbosa , Burin Maira Graeff , Michelin‐Tirelli Kristiane , Leistner‐Segal Sandra , Facchin Ana Carolina Brusius , Medeiros Fernanda S. , Giugliani Luciana , Ribeiro Erlane Marques , Lourenço Charles Marques , Cardoso‐dos‐Santos Augusto César , Ribeiro Márcia Gonçalves , Kim Chong Ae , Castro Matheus Augusto Araújo , Embiruçu Emília Katiane , Steiner Carlos Eduardo , Moreira Maria Lucia Castro , Montano Hector Quintero , Baldo Guilherme , Giugliani Roberto 
Published: November 2021

AbstractMucopolysaccharidosis type IIIB is a rare autosomal recessive disorder characterized by deficiency of the enzyme N‐acetyl‐alpha‐d‐glucosaminidase (NAGLU), caused by biallelic pathogenic variants in the NAGLU gene, which leads to storage of heparan sulfate and a series of clinical consequences which hallmark is neurodegeneration. In this study clinical, epidemiological, and biochemical data were obtained from MPS IIIB patients diagnosed from 2004–2019 by the MPS Brazil Network (“Rede MPS Brasil”), which was created with the goal to provide an easily accessible and comprehensive investigation of all MPS types. One hundred and ten MPS IIIB patients were diagnosed during this period. Mean age at diagnosis was 10.9 years. Patients were from all over Brazil, with a few from abroad, with a possible cluster of MPS IIIB identified in Ecuador. All patients had increased urinary levels of glycosaminoglycans and low NAGLU activity in blood. Main clinical symptoms reported at diagnosis were coarse facies and neurocognitive regression. The most common variant was p.Leu496Pro (30% of alleles). MPS IIIB seems to be relatively frequent in Brazil, but patients are diagnosed later than in other countries, and reasons for that probably include the limited awareness about the disease by health professionals and the difficulties to access diagnostic tests, factors that the MPS Brazil Network is trying to mitigate.
A Phenanthrocarbazole‐Based Dopant‐Free Hole‐Transport Polymer with Noncovalent Conformational Locking for Efficient Perovskite Solar Cells
Authors: Guo Yaxiao , He Lanlan , Guo Jiaxin , Guo Yu , Zhang Fuguo , Wang Linqin , Yang Hao , Xiao Chenhao , Liu Yi , Chen Yongsheng , Yao Zhaoyang , Sun Licheng 
Published: November 2021

AbstractAdequate hole mobility is the prerequisite for dopant‐free polymeric hole‐transport materials (HTMs). Constraining the configurational variation of polymer chains to afford a rigid and planar backbone can reduce unfavorable reorganization energy and improve hole mobility. Herein, a noncovalent conformational locking via S–O secondary interaction is exploited in a phenanthrocarbazole (PC) based polymeric HTM, PC6, to fix the molecular geometry and significantly reduce reorganization energy. Systematic studies on structurally explicit repeats to targeted polymers reveals that the broad and planar backbone of PC remarkably enhances π–π stacking of adjacent polymers, facilitating intermolecular charge transfer greatly. The inserted “Lewis soft” oxygen atoms passivate the trap sites efficiently at the perovskite/HTM interface and further suppress interfacial recombination. Consequently, a PSC employing PC6 as a dopant‐free HTM offers an excellent power conversion efficiency of 22.2 % and significantly improved longevity, rendering it as one of the best PSCs based on dopant‐free HTMs.
Thermo‐Responsive Jamming of Nanoparticle Dense Suspensions towards Macroscopic Liquid–Solid Switchable Materials
Authors: Liu Mingqian , Wan Xizi , Yang Man , Wang Zhao , Bao Han , Dai Bing , Liu Huan , Wang Shutao 
Published: November 2021

AbstractNanoparticle aggregation for constructing functional materials has shown enormous advantages in various applications. Most efforts focused on ordered nanoparticle aggregation for specific functions but were often limited to irreversible aggregation processes due to the thermodynamic equilibrium. Herein, we report a reversible disordered aggregation of SiO2‐PNIPAAm nanoparticles (SPNPs) through thermo‐responsive jamming, obtaining smart liquid–solid switchable materials. The smart materials can display a switch between liquid‐like state and solid‐like state responding to a temperature change. This unique macroscopic behavior originates from the reversible disordered aggregation modulated by temperature‐dependent hydrophobic interactions among the SPNPs. Notably, the materials at the solid‐like state show anti‐impact properties and can withstand the impact of a steel sphere with a speed of 328 cm s−1. We envision that this finding offers inspiration to design smart liquid–solid switchable materials for impact protection.
Polynuclear (α‐diimine) nickel(II) complex as catalyst for ethylene oligomerization
Authors: Li Dan , Ma Fengmin , Guo Lijun , Huang Jin , Zhang Yu , Li Feng , Li Cuiqin 
Published: November 2021

AbstractLate transition metal catalysts with single or multiple active centers have great attention in the ethylene oligomerization application owing to their unique properties. A new polynuclear (α‐diimine) nickel(II) complex (PS‐Ni complex) bearing the conjugated poly(Schiff‐base) ligand (PS‐ligand) was synthesized. The structures and the composition of the PS‐ligand and the PS‐Ni complex were characterized by Fourier transform infrared (FTIR) analysis, X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), thermogravimetric (TG) analysis, nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). The PS‐Ni complex was used as precatalyst in ethylene oligomerization combined with methylaluminoxane (MAO) and has good catalytic activity for ethylene oligomerization under mild conditions. Compared with the corresponding mononuclear (α‐diimine) nickel(II) complex, the PS‐Ni complex showed higher activity of 17.62 × 105 g/(mol Ni•h), and the main products were C4 and C6 olefins in cyclohexane when the dosage of precatalyst was 2 μmol, the Al/Ni molar ratio was 500, the ethylene pressure was 0.5 MPa, the reaction time was 60 min, and the reaction temperature was 25°C. The main oligomers were α‐olefins, and the selectivity was up to 98.68%, due to the more electron‐deficient catalytic centers of the conjugated structure of poly(Schiff‐base) ligand.
Investigating the role of copper and zinc oxide nanomaterials in abatement of biofouling of ultrafiltration membrane in dynamic conditions
Authors: Srivastava Ashish , Raval Hiren D. 
Published: November 2021

AbstractIn the present work, we demonstrate the synthesis, characterization, and biofouling study of polysulfone‐based mixed matrix membranes prepared with hydrophilic CuO and ZnO nanomaterial as antibacterial agents. Permeate flux was increased to 462.2 LMH for PSf/CuO (0.1%) and 472.5 LMH for PSf/ZnO (1.0%) from 191.2 LMH for pure PSf and BSA rejections were enhanced (from 70.91% to 95.73% for PSf/CuO (0.1%), from 70.91% to 93.47% for PSf/ZnO (1.0%). Biofilm growth over the modified membrane (was very less significant as correlated by lower pressure drop compared to pure polysulfone membrane in membrane fouling simulator (MFS) for 48 h. Adhesions of the Escherichia coli bacteria over the membrane surface were analyzed through an alcian blue test followed by a scanning electron micrograph. It was seen that the modified membrane showed a significant anti‐biofouling property with less adherence of alcian blue dye on the membrane surface and scanning electron micrographs demonstrated significantly lower biofouling. Mechanical strength of modified membrane increased up to 62.55 MPa for PSf/CuO (2%) and 55.41 MPa for PSf/ZnO (2%) as compared to 16.41 MPa of PSf membrane.
Borderline personality disorder traits in adolescents with anorexia nervosa
Authors: Lekgabe Edna , Pogos Danielle , Sawyer Susan M. , Court Andrew , Hughes Elizabeth K. 
Published: November 2021

AbstractObjectiveTo examine the correlation between eating disorder (ED) symptoms and borderline personality disorder (BPD) traits in a sample of adolescents with eating disorders.MethodThere were 168 participants (Mage = 16.0 years; SD = 1.16) with a diagnosis of anorexia nervosa (AN) or Eating Disorder Not Otherwise Specified—AN type. Eating Disorder Examination (EDE) and the Borderline Personality Questionnaire (BPQ) were used to assess ED symptoms and BPD traits.ResultsA total of 10 participants (6.6%) scored above the clinical cut‐off for a likely diagnosis of BPD. A positive correlation was observed between BPQ total score and EDE global (rs = 0.64, p < .001). There were also positive correlations between the BPQ self‐image and emptiness subscales and all EDE subscales. Similarly, the EDE eating concern subscale was correlated with all BPQ subscales.DiscussionPrevious studies have demonstrated that some BPD traits (i.e., suicidality, impulsivity, anger) are co‐morbid with ED but the link with other BPD traits has been poorly studied in adolescents and those with AN. These findings indicate that while the prevalence of BPD in adolescents with AN may be relatively low, ED symptom severity is closely related to severity of BPD traits, particularly identity disturbance and feelings of emptiness.
The effect of tempering on protein properties and arabinoxylan contents of intermediate wheatgrass (Thinopyrum intermedium) flour
Authors: Bharathi Radhika , Dai Yaxi , Tyl Catrin , Schoenfuss Tonya , Annor George Amponsah 
Published: November 2021

AbstractBackground and objectivesTo benefit from ecosystem services provided by intermediate wheatgrass (IWG, Thinopyrum intermedium) cultivation, its processing conditions require optimization to facilitate its use in foods. This study assessed tempering as a strategy to improve IWG flour properties relevant for dough making.FindingsTempered IWG samples had significantly higher maximum torque in the GlutoPeak, which strongly correlated with lower contents in total and water‐extractable arabinoxylans (p < .05, r = −0.481; p < .01, r = −0.611) and phosphate buffer‐soluble proteins (p < .01, r = −0.893). While higher maximum torque was observed when IWG was tempered to 14% (compared to 12%), target moisture and tempering time did not have any effect. Tempering induced significant reductions in accessible thiols, which also negatively correlated with maximum torque (p < .05, r = −0.473). SDS‐PAGE analysis, however, did not indicate a shift in flour protein profiles.ConclusionsTempering significantly increased maximum torque and significantly reduced the contents of phosphate buffer‐soluble proteins, accessible thiols, and arabinoxylans. Together, these findings imply increased protein aggregation and an improved IWG protein network.Significance and noveltyThis work demonstrates that the interaction between proteins and arabinoxylans is crucial for IWG dough properties and can be influenced by processing methods.