bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture May Decrease the Incidence of Post-stroke Dementia: A Taiwan Nationwide Retrospective Cohort Study
Authors: Chu Shao-Ang , Chen Te-Yuan , Chen Po-Yuan , Tzeng Wei-Jie , Liang Cheng-Loong , Lu Kang , Chen Han-Jung , Wu Cheng-Chun , Chen Jian-Han , Tsai Chin-Chuan , Wang Hao-Kuang 
Published: May 2021

Background: Post-stroke dementia may affect up to one-third of stroke survivors. Acupuncture as a complementary treatment for stroke has been shown to be beneficial for subsequent post-stroke rehabilitation. The purpose of this retrospective cohort study was to investigate the potential effect of acupuncture to protect stroke patients from dementia.Methods: We included 9,547 patients receiving ambulatory or hospital care for stroke and 9.547 non-stroke patients; patients were matched for sex, age, and Charlson Comorbidity Index. Each individual was traced for the subsequent development of dementia. Two thousand four hundred and forty-nine stroke patients received acupuncture treatment and 7,098 residue stroke patients without acupuncture treatment served as control groups. This is a 3-year follow-up cohorts study: the incidence and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) of post- stroke dementia in the Cox proportional hazard regression.Results: During the 3-year follow-up, 1,403 patients with stroke (14.70%) and 427 patients without stroke (4.47%) developed dementia. The adjusted HRs of development of dementia among stroke patients were 3.64-times (range, 3.27–4.06), and the incidence of dementia was higher in male. Stroke patients receiving acupuncture treatment had a lower probability of dementia than those without acupuncture during the follow-up period, the adjusted HRs was 0.49 (95% CI, 0.42–0.58; p &lt; 0.001).Conclusions: The association between stroke and dementia existed in both sexes, more prominent in male. Patients with stroke receiving acupuncture treatments showed decreased risk of dementia. Care must be taken evaluating these results because this study was limited to lack of information regarding lifestyles, stroke severities, and acupuncture methods that were used in treatments.
CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer’s Disease Involved the cGMP-PKG Signal Pathway
Authors: Zhang Yuan , Qian Lili , Liu Yingying , Liu Ying , Yu Wanpeng , Zhao Yanfang 
Published: May 2021

Background: Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease. The characteristic pathologies include extracellular senile plaques formed by β-amyloid protein deposition, neurofibrillary tangles formed by hyperphosphorylation of tau protein, and neuronal loss with glial cell hyperplasia. Circular RNAs (circRNAs) are rich in miRNA-binding sites (miRNA response elements, MREs), which serve as miRNA sponges or competitive endogenous RNAs (ceRNAs). Although several research groups have identified dysregulated circRNAs in the cerebral cortex of SAMP8 mice or APP/PS1 mice using deep RNA-seq analysis, we need to further explore circRNA expression patterns, targets, functions and the signaling pathways involved in the pathogenesis of AD and in particular the hippocampal circRNA expression profiles in AD.Methods: We used deep RNA sequencing to investigate circRNA-ceRNA network patterns in the hippocampus of APP/PS1 mice.Results: In our study, 70 dysregulated circRNAs, 39 dysregulated miRNAs and 121 dysregulated mRNAs were identified between the APP/PS1 group and the wild-type group at 8 months in the hippocampus of the mice. Through correlation analysis, we identified 11 dysregulated circRNAs, 7 dysregulated miRNAs and 8 dysregulated mRNAs forming 16 relationships in the circRNA-miRNA-mRNA regulatory network. Gene ontology (GO) analysis indicated that the dysregulated circRNAs were most enriched in biological metabolic processes. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the dysregulation of circRNAs was enriched in the cGMP-PKG signaling pathway, cAMP signaling pathway, Hippo signaling pathway, platelet activation, long-term potentiation and axon guidance. In addition, our findings preliminarily verified that the novel_circ_0003012/mmu-miR-298-3p/Smoc2 signaling axis may regulate the pathophysiology of AD by affecting the cGMP-PKG signaling pathway.Conclusions: These newly identified circRNAs in networks and signaling pathways reveal potential diagnostic or therapeutic targets for AD.
The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019
Authors: Xu Shangbo , Liu Yiyuan , Zhang Taofeng , Zheng Jiehua , Lin Weixun , Cai Jiehui , Zou Juan , Chen Yaokun , Xie Yanna , Chen Yexi , Li Zhiyang 
Published: May 2021

BackgroundThe burden of breast cancer has been increasing globally. The epidemiology burden and trends need to be updated. This study aimed to update the burden and trends of breast cancer incidences, deaths, and disability-adjusted life-years (DALYs) from 1990 to 2019, using the Global Burden of Disease 2019 study.MethodsThe data of incidences, deaths, DALYs, and age-standardized rates were extracted. Estimated annual percentage changes were used to quantify the trends of age-standardized rates. Besides, the population attributable fractions of the risk factors of breast cancer were also estimated.ResultsGlobally, the incidences of breast cancer increased to 2,002,354 in 2019. High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. In 2019, the global deaths and DALYs of breast cancer increased to 700,660 and 20,625,313, respectively. From 1990 to 2019, the age-standardized mortality rates and age-standardized DALY rates declined globally, especially in high and high-middle SDI quintiles. Besides, the trends varied from different regions and countries. The proportion of the patients in the 70+ years age group increased globally. Deaths of breast cancer attributable to high fasting plasma glucose and high body mass index increased globally, and high fasting plasma glucose was the greatest contributor to the global breast cancer deaths.ConclusionThe burden of breast cancer in higher SDI quintiles had gone down while the burden was still on the rise in lower SDI quintiles. It is necessary to appeal to the public to decrease the exposure of the risk factors.
Genistein From Fructus sophorae Protects Mice From Radiation-Induced Intestinal Injury
Authors: Zhang Jieyu , Pang Zhijun , Zhang Yuting , Liu Jiaxin , Wang Zhaowei , Xu Chuanyang , He Lei , Li Weina , Zhang Kuo , Zhang Wangqian , Wang Shuning , Zhang Cun , Hao Qiang , Zhang Yingqi , Li Meng , Li Zhengmin 
Published: May 2021

The development of an effective pharmacological countermeasure is needed to reduce the morbidity and mortality in high-dose ionizing radiation-induced acute damage. Genistein has shown bioactivity in alleviating radiation damage and is currently synthesized by chemosynthetic methods. Due to concerns about chemical residues and high costs, the clinical application of genistein is still a major challenge. In this study, we aimed to establish an efficient method for the extraction of genistein from Fructus sophorae. The effects of extracted genistein (FSGen) on preventing intestinal injury from radiation were further investigated in this study. C57/BL mice were exposed to 7.5 Gy whole body irradiation with and without FSGen treatments. Histological analysis demonstrated significant structural and functional restitution of the intestine and bone marrow in FSGen-pretreated cohorts after irradiation. Through mRNA expression, protein expression, and small interfering RNA analyses, we demonstrated that FSGen protects IEC-6 cells against radiation damage by upregulating the Rassf1a and Ercc1 genes to effectively attenuate DNA irradiation damage. Together, our data established an effective method to extract genistein from the Fructus sophorae plant with high purity, and validated the beneficial roles of the FSGen in protecting the radiation damage. These results promise the future applications of Fructus sophorae extracted genistein in the protection of radiation related damages.
Molecular Action of Hydroxytyrosol in Attenuation of Intimal Hyperplasia: A Scoping Review
Authors: Vijakumaran Ubashini , Yazid Muhammad Dain , Hj Idrus Ruszymah Bt , Abdul Rahman Mohd Ramzisham , Sulaiman Nadiah 
Published: May 2021

Objective: Hydroxytyrosol (HT), a polyphenol of olive plant is well known for its antioxidant, anti-inflammatory and anti-atherogenic properties. The aim of this systematic search is to highlight the scientific evidence evaluating molecular efficiency of HT in halting the progression of intimal hyperplasia (IH), which is a clinical condition arises from endothelial inflammation.Methods: A systematic search was performed through PubMed, Web of Science and Scopus, based on pre-set keywords which are Hydroxytyrosol OR 3,4-dihydroxyphenylethanol, AND Intimal hyperplasia OR Neointimal hyperplasia OR Endothelial OR Smooth muscles. Eighteen in vitro and three in vitro and in vivo studies were selected based on a pre-set inclusion and exclusion criteria.Results: Based on evidence gathered, HT was found to upregulate PI3K/AKT/mTOR pathways and supresses inflammatory factors and mediators such as IL-1β, IL-6, E-selectin, P-selectin, VCAM-1, and ICAM-1 in endothelial vascularization and functioning. Two studies revealed HT disrupted vascular smooth muscle cells (SMC) cell cycle by dephosphorylating ERK1/2 and AKT pathways. Therefore, HT was proven to promote endothelization and inhibit vascular SMCs migration thus hampering IH development. However, none of these studies described the effect of HT collectively in both vascular endothelial cells (EC) and SMCs in IH ex vivo model.Conclusions: Evidence from this concise review provides an insight on HT regulation of molecular pathways in reendothelization and inhibition of VSMCs migration. Henceforth, we propose effect of HT on IH prevention could be further elucidated through in vivo and ex vivo model.
Preclinical Investigation of Alpinetin in the Treatment of Cancer-Induced Cachexia via Activating PPARγ
Authors: Zhang Yujie , Zhang Yuxin , Li Yichen , Zhang Li , Yu Shiying 
Published: May 2021

The ongoing loss of skeletal muscle is a central event of cancer cachexia, and its consequences include adverse effects on patient’s quality of life and survival. Alpinetin (Alp), a natural plant-derived flavonoid obtained from Alpinia katsumadai Hayata, has been reported to possess potent anti-inflammatory and antitumor activities. This study aimed to explore the therapeutic effect and underlying mechanism of Alp in the prevention of cancer cachexia. We found that Alp (25–100 μM) dose-dependently attenuated Lewis lung carcinoma–conditioned medium-induced C2C12 myotube atrophy and reduced expression of the E3 ligases Atrogin-1 and MuRF1. Moreover, Alp administration markedly improved vital features of cancer cachexia in vivo with visible reduction of the loss of tumor-free body weight and wasting of multiple tissues, including skeletal muscle, epididymal fat, and decreased expression of Atrogin-1 and MuRF1 in cachectic muscle. Alp suppressed the elevated spleen weight and serum concentrations of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6. Further, Alp treatment remained protective against cancer cachexia in the advanced stage of tumor growth. Molecular docking results suggested that Alp was docked into the active site of PPARγ with the docking score of –7.6 kcal/mol, forming a hydrogen bond interaction with PPARγ protein amino acid residue HIS449 with a bond length of 3.3 Å. Mechanism analysis revealed that Alp activated PPARγ, resulting in the downregulated phosphorylation of NF-κB and STAT3 in vitro and in vivo. PPARγ inhibition induced by GW9662 notably attenuated the improvement of Alp on the above cachexia phenomenon, indicating that PPARγ activation mediated the therapeutic effect of Alp. These findings suggested that Alp might be a potential therapeutic candidate against cancer cachexia.
Calibration of the DSCOVR EPIC Visible and NIR Channels using Multiple LEO Radiometers
Authors: Geogdzhayev Igor V. , Marshak Alexander , Alexandrov Mikhail 
Published: May 2021

The first five years of operation of the Deep Space Climate Observatory (DSCOVR) Earth Polychromatic Imaging Camera (EPIC) at the Lagrange one point have produced results that uniquely complement the data from currently operating low orbit Earth-observing instruments. In this paper we describe an updated unified approach to EPIC calibration. In this approach, calibration coefficients and their trends were obtained by comparing EPIC observations to the measurements from polar orbiting radiometers. In this study L1B reflectances from Moderate Resolution Imaging Spectroradiometer (MODIS) onboard the Aqua and Terra satellites, Multi-angle Imaging Spectroradiometer (MISR) onboard Terra and Visible Infrared Imaging Radiometer (VIIRS) onboard the Suomi National Polar-orbiting Partnership (Suomi NPP) spacecraft were used to infer calibration coefficients for four EPIC visible and near-infrared channels: 443 nm, 551 nm, 680 nm, and 780 nm. EPIC Version three measurements made between June 2015 and August 2020 were used for comparison. The calibration procedure identifies the most homogeneous low Earth orbit radiometer scenes matching scattering angles that are temporarily and spatially collocated with EPIC observations. These scenes are used to determine reflectance to count (R/C) ratios in spectrally analogous channels. Seasonal average R/C ratios were analyzed to obtain EPIC calibration gains and trends. The trends for the full dataset period are not statistically significant except in the 443 nm channel. No significant changes in calibration were found after the instrument’s exit from safe hold in March 2020. The R/C ratios were also used to determine the differences in EPIC gains resulting from separate calibrations: against MODIS Aqua or Terra, as well as against forward or aftward MISR cameras. Statistical tests indicate that the differences between the two datasets are not significant except in the 780 nm channels where Aqua-derived coefficients may be around 2% lower compared to Terra. The dependence of EPIC calibration gains on the instrument scattering angle and on DSCOVR-Earth distance were investigated. Lastly, model Low Earth Orbit (LEO) reflectances calculated to match the EPIC viewing geometry were employed to study how EPIC calibration coefficients depend on EPIC-LEO viewing geometry differences. The effect of LEO and EPIC angular mismatch on calibration was shown to be small.
Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients
Authors: Xiao Jianchun , Zhao Zixuan , Li Binglu , Zhang Taiping 
Published: May 2021

Purpose: To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma.Methods: In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019.Results: Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters &lt;10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients.Conclusions: The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.
METHODOLOGICAL PRINCIPLES OF POSTNONCLASSICAL PSYCHOLOGY
Authors: I. Titov  
Published: May 2021

The transformation of psychological science at postnonclassical stage of its development demands theoretical and methodological reflection of the conceptual grounds of psychology. In this article, we have attempted to outline themost significant principles regarded to postnonclassicalpsychology such as 1) structural- genetic principle; 2) principle of subject (personal agency); 3) principle of orientation on cultural context; 4) principle of ontological constructivism; 5) principle of integration.Structural-genetic principlegrounds the view on psychological phenomenon as the unique and integral formation,which is able to self-organization and self- development. This principle emphasizes the necessity to consider a) structural peculiarities of such phenomenon (level of inner differentiation and integration of its components, dynamics of functional coordination between them); b) ordering influences of system-creating factor on it; c) diachronic aspects of its functioning (determination, mechanisms, stages, synergy effects etc.).The principle of subject (personal agency) focuses on the content and dynamic (motivational and value, cognitive, regulative and reflexive etc.) aspects of person’s interaction with the world.The principle of orientation on cultural contextprinciple proposes to interpret mental phenomena as the modus of culture, taking into consideration the interconnection between generative worlds of culture and subjective worlds of the human.The principle of ontological constructivism points out the constructive (mediated by constructs, narrative structures etc.) nature ofthe cognition. It indicates that personal mental constructions are to be ideal models (hypertext representations of the world which provide interpretative and adaptive functions) based on conventional assumptions about the reality.The principle of integration reveals the possibility ofa) inter-paradigmdialogue and inter-disciplinary synthesis, content interaction between different psychological theories; b) complex applying of different research strategies and methods; c) combination of the fundamental theoretical achievements with the practical technologies.
MODERN VECTORS OF THE STUDY OF EMOTIONAL INTELLIGENCE OF AN INDIVIDUAL
Authors: Karpenko Ye. 
Published: May 2021

The article deals with the theoretical analysis of modern approaches to the study of emotional intelligence (EQ) of an individual. The classic understanding of EQ maintains that emotions are localized in the brain and one must learn to distinguish, control, regulate and direct them for the successful functioning in the domains of Activity, Contact and Body Functions. In accordance with this view, the emotional sphere is subject to rational thinking, which prevents affect from going beyond the limits of socially acceptable norms. It is believed that emotions arise under the influence of external or internal stimuli, which an individual has to react to using brain structures. Neocortex limits possible negative effects of a hasty response to external stimuli by the limbic system, in general, and the almond-shaped body, in particular. In its turn, this raises the quality of human life in society, the level of self-awareness, self-regulation and ultimately contributes to the achievement of success.The post-nonclassical approach extends the concept of emotions, and hence the potential of studying EQ. It places a major emphasis on the neurological nature of their construction by an individual. Thus, an individual constructs a psychic reality based on past experience, taking into account the actual environment conditions. The interoceptive brain network is responsible for its construction while the controlling brain network monitors its functioning. Thus, emotions are the product of human creativity and are not localized in certain brain structures. They are also mutually determined with the dominant discourse in society.The post-nonclassical view on emotions is not capable of explaining the axiological vector of EQ more effectively, as can distinctly be seen in the study of personal life fulfillment. In this perspective, the EQ components appear to be the organismic sense and emotional competence, which are also the mechanisms of understanding and interpretation, respectively.
THEORETICAL APPROACHES TO THE SUBMISSION OF PSYCHOLOGICAL STRUCTURE OF PERSONAL RELIABILITY OF SUBJECTS OF BUSINESS ACTIVITIES
Authors: Lantukh I. 
Published: May 2021

The article deals with the issues of theoretical and methodological substantiation of the study of the psychological structure of personal reliability of business entities. A series of theoretical peculiarities of reliability research of entrepreneurs is described. Conceptual approaches that deepen the concept of personal reliability and expand knowledge about the psychological structure of business entities are presented and described. Development and formation of personal reliability of entrepreneurs in professional activity should be considered in the following directions – activity, reliability and community. So, professional activity of entrepreneurs is inter-subjective: professional reliability is based on positive self-determination in interaction, and professional community is due to the inclusion of entrepreneurs in collective activities, which is based on positive self- identification with the participants of the interaction. Accordingly, one should pay attention to the fact that the subject of entrepreneurial activity acts simultaneously as an organizer, designer, carrier of a personal position, which involves self- determination, self-organization, self-conscious professional activity. The prospect of further research is a combination of relatively homogeneous components of the personality of a specialist with a wider system of professional qualities of an entrepreneur. From these positions, the structural analysis of the entrepreneurial professional potential enables one to study not only personal qualities, but also the influence of the social environment, which combines the internal and external characteristics of the specialist in his professional development.
SYNERGY EFFECT OF PSYCHOLOGICAL AND PEDAGOGICAL INTERACTION OF THE SYSTEMS “FAMILY” AND “SCHOOL”
Authors: Sedykh K. 
Published: May 2021

The article is devoted to studies of the psychology of interaction of families and educational institutions. Through a prism of genetic psychology and the system approach as methodological paradigm of research theoretic and empirical study of interaction of a family with educational social institutions was carried out. Features of families and educational institutions as systems were explored. The complete system analysis of a phenomenon of intersystem interaction between systems “family” and “educational institution” is carried out.
The interaction concept between a family and an educational institution is developed, interaction is the backbone factor. The educational institution has the double nature of the organization: it is a formal structure which is created by society for realization of teaching and educational process; and it is a system, which is being self-administrated.