bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sunrise integrals with two internal masses and pseudo-threshold kinematics in terms of elliptic polylogarithms
Authors: Campert Lijsbeth G. J. , Moriello Francesco , Kotikov Anatoly 
Published: September 2021

Abstract
We consider a set of two-loop sunrise master integrals with two different internal masses at pseudo-threshold kinematics and we solve it in terms of elliptic polylogarithms to all orders of the dimensional regulator.
Understanding the surface integrity of laser surface engineered tungsten carbide
Authors: Hazzan Kafayat Eniola , Pacella Manuela , See Tian Long 
Published: September 2021

AbstractThe study investigated the effect of fibre laser processing (1060 nm, 240-ns pulse duration) on the surface integrity of tungsten carbide (WC). The induced surface damage ranged from crack formation, porosity, balling, to spherical pores; the severity and presence of each were dependent on the laser parameters selected. The influence of fluence (0.05–0.20 J/cm2), frequency (5–100 kHz), feed speed (250–2500 mm/s) and hatch distance (0.02–0.06 mm) on 2D and 3D surface roughness were analysed using the Taguchi technique. Fluence, frequency, and the interaction effect of these were the most influential factors on the surface integrity; from this a linear model was generated to predict the surface roughness. The model performed best at moderate to medium level of processing with an error between 1 and 10 %. The model failed to predict the material response as accurately at higher fluences with percentage errors between 15 and 36 %. In this study, a crack classification system and crack density variable were introduced to estimate the number of cracks and crack type within a 1-mm2 area size. Statistical analysis of variance (ANOVA) found that fluence (63.49%) and frequency (29.38%) had a significant effect on the crack density independently but not the interaction of both. The crack density was minimised at 0.149 J/cm2 and 52.5 kHz. To the author’s knowledge, for the first time, a quantitative analysis of the crack formation mechanism for brittle materials is proposed (post laser processing).
The impact of constant antibiotic prophylaxis in children affected by spinal dysraphism performing clean intermittent catheterization: a 2-year monocentric retrospective analysis
Authors: Mariani Francesco , Ausili Emanuele , Zona Margherita , Grotti Giacomo , Curatola Antonietta , Gatto Antonio , Rendeli Claudia 
Published: September 2021

Abstract
Introduction
Spinal dysraphism (SD) is a general term used to refer to developmental abnormalities of the spine that involves many clinical conditions including myelomeningocele (MMC). In these patients, neurogenic bladder (NB) is a common and predisposing factor for renal damage; the most frequently used approach to manage this situation is based on clean intermittent catheterization (CIC) and anticholinergic drugs. Urinary tract infections (UTIs) are a significant concern for these patients, and antibiotic prophylaxis is frequently used even if it is still a debated topic of literature. The purpose of this paper is to investigate the role and the real effectiveness of antibiotic prophylaxis in the reduction of incidence of UTIs in patients with spina bifida performing CIC.

Methods
We collected data of all patients performing CIC, who did their last follow-up visit in the period between January 2019 and January 2021, followed at the children multidisciplinary Spina Bifida Center of A. Gemelli Hospital in Rome. Data collected included age at referral, gender, type of SD lesion, serum creatinine and cystatin C levels, the use of anticholinergic medications, antibiotic prophylaxis and type of prophylaxis (oral/endovesical), age of starting prophylaxis with its duration/adherence, number of CIC/day and its duration, episodes of UTIs in the 2 years prior to the last follow-up, and presence and grade of vesical-ureteric reflux (VUR) on cystourethrogram.

Results
A total of 121 patients with SD performing CIC was included in the study; 66 (54%) presented ≥ 1 episode of UTIs in the last two years and 55 (46%) none. During the study period, 85 (70%) patients received antibiotic prophylaxis (ABP group) and 36 (30%) did not (NABP group): no statistically significative difference in terms of UTI development was observed between the two groups (p = 0.17). We also evaluated compliance to the therapy; 71 patients (59%) took antibiotic prophylaxis constantly (CABP group) and 50 (41%) did not do antibiotic prophylaxis constantly or did not do antibiotic prophylaxis at all (NCABP group): we observed a statistically significative difference in terms of UTIs with a 2.2 times higher risk of development at least one episode of UTIs in NCABP group.

Conclusion
In conclusion, antibiotic prophylaxis performed constantly, without interruption, is associated with a lower risk of developing urinary tract infections and consequently to develop renal failure in adulthood.
Analysis of the interannual variability in satellite gravity solutions: detection of climate modes fingerprints in water mass displacements across continents and oceans
Authors: Pfeffer Julia , Cazenave Anny , Barnoud Anne 
Published: September 2021

AbstractThis study analyzes the interannual variability of the water mass transport measured by satellite gravity missions in regard to eight major climate modes known to influence the Earth’s climate from regional to global scales. Using sparsity promoting techniques (i.e., LASSO), we automatically select the most relevant predictors of the climate variability among the eight candidates considered. The El Niño–Southern Oscillation, Southern Annular Mode and Arctic Oscillation are shown to account for a large part the interannual variability of the water mass transport observed in extratropical ocean basins (up to 40%) and shallow seas (up to 70%). A combination of three Pacific and one Atlantic modes is needed to account for most (up to 60%) of the interannual variability of the terrestrial water storage observed in the North Amazon, Parana and Zambezi basins. With our technique, the impact of climate modes on water mass changes can be tracked across distinct water reservoirs (oceans, continents and ice-covered regions) and we show that a combination of climate modes is necessary to explain at best the natural variability in water mass transport. The climate modes predictions based on LASSO inversions can be used to reduce the inter-annual variability in satellite gravity measurements and detect processes unrelated with the natural variability of climate but with similar spatio-temporal signatures. However, significant residuals in the satellite gravity measurements remain unexplained at inter-annual time scales and more complex models solving the water mass balance should be employed to better predict the variability of water mass distributions.
Sleep disturbances in craniopharyngioma: a challenging diagnosis
Authors: Cordani Ramona , Veneruso Marco , Napoli Flavia , Milanaccio Claudia , Verrico Antonio , Consales Alessandro , Cataldi Matteo , Fava Daniela , Di Iorgi Natascia , Maghnie Mohamad , Mancardi Maria Margherita , Nobili Lino 
Published: September 2021

AbstractCraniopharyngiomas are rare solid or mixed solid and cystic tumors that arise from Rathke’s pouch remnants along the pituitary-hypothalamic axis, from the sella turcica to the brain third ventricle. Both the tumor and its treatment can lead to significant neurological and endocrinological complications. Due to the essential role of the hypothalamus in the complex neurophysiologic process of sleep, tumors involving the hypothalamic area may be responsible for disturbances in sleep–wake regulation with alterations in the circadian rhythm, sleep fragmentation, and increased daytime sleepiness. We report two cases of patients with craniopharyngioma, who came to our attention due to the occurrence of episodes characterized by psychomotor slowing and afinalistic limb movements, temporal and spatial disorientation, psychomotor agitation, and oneiric stupor like episodes. A comprehensive clinical data collection and a targeted diagnostic work-up led to a diagnosis of severe sleep disorder characterized by hypersomnia, altered sleep–wake rhythm, and sleep-related breathing disorder. In addition, the polysomnography revealed peculiar alterations in the sleep structure. The diagnostic work-up lead to an accurate differential diagnosis between epileptic seizures and episodes expressions of sleep disturbances. These clinical features can be challenging to diagnose and can lead to misdiagnosis and inappropriate treatment. Diagnosis of sleep disorders is crucial, considering the impact of sleep on general health, cognition, and neuropsychological functioning. These findings support the need to incorporate a comprehensive sleep evaluation in childhood brain tumor involving the suprasellar/hypothalamic region.
Prevalence and clinical features of autosomal dominant and recessive TMC1-associated hearing loss
Authors: Nishio Shin-ya , Usami Shin-ichi 
Published: September 2021

AbstractTMC1 is a causative gene for both autosomal dominant non-syndromic hearing loss (DFNA36) and autosomal recessive non-syndromic hearing loss (DFNB7/11). To date, 125 pathogenic variants in TMC1 have been reported. Most of the TMC1 variants are responsible for autosomal recessive hearing loss, with only 8 variants reported as causative for DFNA36. Here, we reported the prevalence of TMC1-associated hearing loss in a large non-syndromic hearing loss cohort of about 12,000 subjects. As a result, we identified 26 probands with TMC1-associated hearing loss, with the estimated prevalence of TMC1-associated hearing loss in the Japanese hearing loss cohort being 0.17% among all patients. Among the 26 probands with TMC1-associated hearing loss, 15 cases were identified from autosomal dominant hearing loss families. Based on the audiometric data from the probands, family members and previously reported cases, we evaluated hearing deterioration for DFNA36 patients. In addition, we performed haplotype analysis for 11 unrelated autosomal dominant hearing loss families carrying the same variant TMC1: NM_138691:c.1627G > A:p.Asp543Asn. The results clearly indicated that the same haplotype was present despite the families being unrelated, supporting the contention that this variant occurred by founder mutation.
Differential genetic diagnoses of adult post-lingual hearing loss according to the audiogram pattern and novel candidate gene evaluation
Authors: Rim John Hoon , Noh Byunghwa , Koh Young Ik , Joo Sun Young , Oh Kyung Seok , Kim Kyumin , Kim Jung Ah , Kim Da Hye , Kim Hye-Youn , Yoo Jee Eun , Lee Seung-Tae , Bok Jin Woong , Lee Min Goo , Jung Jinsei , Choi Jae Young , Gee Heon Yung 
Published: September 2021

AbstractSki-slope hearing loss (HL), which refers to increased auditory threshold at high frequencies, is common in adults. However, genetic contributions to this post-lingual HL remain largely unknown. Here, we prospectively investigated deafness-associated and novel candidate genes causing ski-slope HL. We analyzed 192 families with post-lingual HL via gene panel and/or exome sequencing. With an overall molecular diagnostic rate of 35.4% (68/192) in post-lingual HL, ski-slope HL showed a lower diagnostic rate (30.7%) compared with other conditions (40.7%). In patients who showed HL onset before the age of 40, genetic diagnostic probability was significantly lower for ski-slope HL than for other conditions. Further analysis of 51 genetically undiagnosed patients in the ski-slope HL group identified three variants in delta-like ligand 1 (DLL1), a Notch ligand, which presented in vitro gain-of-function effects on Notch downstream signaling. In conclusion, genetic diagnostic rates in post-lingual HL varied according to audiogram patterns with age-of-onset as a confounding factor. DLL1 was identified as a candidate gene causing ski-slope HL.
Magma chamber stratification of the 1815 Tambora caldera-forming eruption
Authors: Suhendro Indranova , Toramaru Atsushi , Miyamoto Tomoharu , Miyabuchi Yasuo , Yamamoto Takahiro 
Published: September 2021

AbstractThe eruption of the Tambora volcano in 1815 was initiated by two precursory Plinian falls and formed two generations of pyroclastic density current (PDC) deposits. In this study, we found slight changes in phenocrysts (modal mineralogy, content, and size), bulk-rock and feldspar microlite chemical compositions, and bubble and microlite number densities through the stratigraphic position. Plinian fall units are characterized by a lower phenocryst abundance (avg. of 5.1%), smaller phenocryst size (avg. of 0.06 mm2), and higher silica content (bulk-rock, 58–58.5 wt.%). The PDC deposits are characterized by a relatively higher crystal abundance (avg. of 12.1%), larger phenocryst sizes (avg. of 0.13 mm2), and lower silica content (bulk-rock, 56.7–57.9 wt.%). Therefore, the deposit stratigraphy and analyses suggest that phenocryst stratification in the magma chamber was established prior to the 1815 eruption and was thus responsible for yielding a slight contrast in bulk compositions. Feldspar microlite moves toward slightly more albitic compositions from Plinian falls to the PDCs, suggesting a slight decrease in the initial melt temperature from the upper to the lower magma chamber portion. Because the Plinian eruptions extracted the hottest magma, the degree of supercooling became low, and consequently yielded microlite-poor juveniles. By contrast, the PDCs experienced a larger degree of supercooling because the temperature was relatively low, thus yielding microlite-rich juveniles. Moreover, such temperature stratification coupled with the evidence of homogeneous melt composition (58.5–58.9 wt.% SiO2) and the minor evidence of crystal mush (at most 27%) might suggest that the Tambora case is still in the early stage of magmatic evolution under cooling from the surrounding rocks.
Metabolic control analysis of L-tryptophan producing Escherichia coli applying targeted perturbation with shikimate
Authors: Schoppel Kristin , Trachtmann Natalia , Mittermeier Fabian , Sprenger Georg A. , Weuster-Botz Dirk 
Published: September 2021

AbstractL-tryptophan production from glycerol with Escherichia coli was analysed by perturbation studies and metabolic control analysis. The insertion of a non-natural shikimate transporter into the genome of an Escherichia coli L-tryptophan production strain enabled targeted perturbation within the product pathway with shikimate during parallelised short-term perturbation experiments with cells withdrawn from a 15 L fed-batch production process. Expression of the shikimate/H+-symporter gene (shiA) from Corynebacterium glutamicum did not alter process performance within the estimation error. Metabolic analyses and subsequent extensive data evaluation were performed based on the data of the parallel analysis reactors and the production process. Extracellular rates and intracellular metabolite concentrations displayed evident deflections in cell metabolism and particularly in chorismate biosynthesis due to the perturbations with shikimate. Intracellular flux distributions were estimated using a thermodynamics-based flux analysis method, which integrates thermodynamic constraints and intracellular metabolite concentrations to restrain the solution space. Feasible flux distributions, Gibbs reaction energies and concentration ranges were computed simultaneously for the genome-wide metabolic model, with minimum bias in relation to the direction of metabolic reactions. Metabolic control analysis was applied to estimate elasticities and flux control coefficients, predicting controlling sites for L-tryptophan biosynthesis. The addition of shikimate led to enhanced deviations in chorismate biosynthesis, revealing a so far not observed control of 3-dehydroquinate synthase on L-tryptophan formation. The relative expression of the identified target genes was analysed with RT-qPCR. Transcriptome analysis revealed disparities in gene expression and the localisation of target genes to further improve the microbial L-tryptophan producer by metabolic engineering.
Evaluation of the Diametrical Core Deformation and Discing Analyses for In-Situ Stress Estimation and Application to the 4.9 km Deep Rock Core from the Basel Geothermal Borehole, Switzerland
Authors: Ziegler Martin , Valley Benoît 
Published: September 2021

AbstractThe in situ state of rock mass stresses is a key design parameter, e.g., for deep engineered geothermal systems. However, knowledge of the stress state at great depths is sparse mostly because of the lack of possible in situ tests in deep boreholes. Among different options, core-based in situ stress estimation may provide valuable stress information though core-based techniques have not yet become a standard. In this study we focus on the Diametrical Core Deformation Analysis (DCDA) technique using monzogranitic to monzonitic rock drill cores from 4.9 km depth of the Basel-1 borehole in Switzerland. With DCDA the maximum and minimum horizontal stress (SHmax and Shmin) directions, and the horizontal differential stress magnitudes (∆S) can be estimated from rock cores extracted from vertical boreholes. Our study has three goals: first, to assess photogrammetric core scanning to conduct DCDA; second, to compare DCDA results with borehole breakout and stress-induced core discing fracture (CDF) data sets; and third, to investigate the impact of rock elastic anisotropy on ∆S. Our study reveals that photogrammetric scanning can be used to extract reliable core diametrical data and CDF traces. Locally aligned core pieces showed similar SHmax orientations, conform to borehole breakout results. However, the variability of core diametrical differences was large for the Basel-1 core pieces, which leads to a large spread of ∆S. Finally, we demonstrate that core elastic anisotropy must be considered, requiring robust estimates of rock elastic moduli, to receive valuable stress information from DCDA analyses.
Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults
Authors: Elkafrawy Hagar , Mehanna Radwa , Ali Fayrouz , Barghash Ayman , Dessouky Iman , Jernerén Fredrik , Turner Cheryl , Refsum Helga , Elshorbagy Amany 
Published: September 2021

AbstractPlasma cysteine is associated with human obesity, but it is unknown whether this is mediated by reduced, disulfide (cystine and mixed-disulfides) or protein-bound (bCys) fractions. We investigated which cysteine fractions are associated with adiposity in vivo and if a relevant fraction influences human adipogenesis in vitro. In the current study, plasma cysteine fractions were correlated with body fat mass in 35 adults. Strong positive correlations with fat mass were observed for cystine and mixed disulfides (r ≥ 0.61, P < 0.001), but not the quantitatively major form, bCys. Primary human preadipocytes were differentiated in media containing cystine concentrations varying from 10–50 μM, a range similar to that in plasma. Increasing extracellular cystine (10–50 μM) enhanced mRNA expression of PPARG2 (to sixfold), PPARG1, PLIN1, SCD1 and CDO1 (P = 0.042– < 0.001). Adipocyte lipid accumulation and lipid-droplet size showed dose-dependent increases from lowest to highest cystine concentrations (P < 0.001), and the malonedialdehyde/total antioxidant capacity increased, suggesting increased oxidative stress. In conclusion, increased cystine concentrations, within the physiological range, are positively associated with both fat mass in healthy adults and human adipogenic differentiation in vitro. The potential role of cystine as a modifiable factor regulating human adipocyte turnover and metabolism deserves further study.
Productivity and the pandemic: short-term disruptions and long-term implications
Authors: de Vries Klaas , Erumban Abdul , van Ark Bart 
Published: September 2021

AbstractThis paper analyses quarterly estimates of productivity growth at industry level for three advanced economies, France, the UK and the US, for 2020. We use detailed industry-level data to distinguish reallocations of working hours between industries from pure within-industry productivity gains or losses. We find that all three countries showed positive growth rates of aggregate output per hour in 2020 over 2019. However, after removing the effects from the reallocation of hours between low and high productivity industries, only the US still performed positively in terms of within-industry productivity growth. In contrast, the two European economies showed negative within-industry productivity growth rates in 2020. While above-average digital-intensive industries outperformed below-average ones in both France and the UK, the US showed higher productivity growth in both groups compared to the European countries. Industries with medium-intensive levels of shares of employees working from home prior to the pandemic made larger productivity gains in 2020 than industries with the highest pre-pandemic work-from-home shares. Overall, after taking into account the productivity collapse in the hospitality and culture sector during 2020, productivity growth shows no clear deviation from the slowing pre-pandemic productivity trend. Future trends in productivity growth will depend on whether the favourable productivity gains (or smaller losses) in industries with above-average digital intensity will outweigh negative effects from the pandemic, in particular scarring effects on labour markets and business dynamics.
Vaccine-masked spread of SARS-CoV2 in an elderly care home, and how to prevent a spill-over into the general population
Authors: Weigl Josef A. I. , Werlang Thorsten , Wessendorf Michael , Helbing Holger 
Published: September 2021

Abstract
Aim
The vaccination campaign against SARS-CoV2 in Germany started at the peak of the second wave. An outbreak in an elderly care home occurred in our county at the time of the second vaccination. We describe a package of measures to control the outbreak and to prevent a spill over into the general population.

Subjects and methods
After outbreak confirmation, a package of measures such as quarantine of the elderly care home, staff and visitors, and their households was implemented. By sequential testing, quarantine measures were lifted. Surveillance of staff and residents by rapid antigen test and symptom monitoring was used in parallel.

Results
The outbreak was on-going for around 17 days until it was noticed by a symptomatic external staff member as index case. A total of 23 out of 96 residents (24.0%) and nine out of 114 staff (7.9%) were infected. Three residents died. Effective first-dose vaccine coverage was 85.4% in residents, 27.4% in internal, and 10.5% in external staff. Given the long latency period, the use of household quarantine prevented a spill over into the public. Already 16 days after notification of the index case the outbreak could be declared over.

Conclusions
Interferences between vaccination coverage and outbreak characteristics in regard to an extended latency period were observed. Household quarantine of case as well as contact households is of increased importance in the era of vaccination to prevent further spread into the general population until population-based control measures and lockdowns can be lifted.