bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of Standard Four-Port, Three Port and Single Incision Laparoscopic Cholecystectomy Performed by a Single Surgeon in Nobel Medical College Teaching Hospital, Nepal
Authors: Sulaimankulov Ruslan , Jolochieva Gulmira 
Published: June 2021

Introduction: Laparoscopic Cholecystectomy is a standard operative procedure for patients with gallbladder diseases and is the most common laparoscopic procedure performed worldwide. The aim of this study is to analyze the different methods of laparoscopic cholecystectomies done by a single surgeon at Nobel Medical College Teaching Hospital.
Objectives: The objective and aim of this study are comparing 4 port classic Laparoscopic Cholecystectomy (4PLC), 3 port (3PLC) and Laparo-Endoscopic Single-Site Cholecystectomy (LESC) performed by a single surgeon and correlate worldwide experience with outcomes in our institution.
Methodology: The study includes retrospective analysis of 8192 patients who underwent elective laparoscopic Cholecystectomy (LC) from October 2010 to July 2020 performed by the single surgeon. All cases divided into 3 groups depending on the type of LC (4PLC, 3PLC, LESC). The data included the type of the surgery, gender, age, operative time, conversion and complication rate and duration of hospital stay.
Results: The hospital stays, operation time and conversion rate decreased from group I to group III. Female patients out numbered the male ones (M:F=1:4). The hospital stays (3.4 days), operation time (35 min), conversion (0.4%) and complications (0.7%) rate decreased from Group of 4PLC to Group of LESC (1.5 days, 13 min, 0.1% conversion, 0.4% complication respectively) which is true for almost all other similar studies.
Conclusion: The advantages of LESC include a better cosmetic effect and reduced chance of infections. It has been postulated to be superior in scarless surgery with added benefits of lower pain level and reduced need for analgesics, shorter hospital stays, quicker return to work and lower financial expenses.
Prevalence of Hyperuricemia and its Association with Sociodemography among Hypertensive Patients at Birat Medical College Teaching Hospital
Authors: Mehta Ram Kumar , Mallick Ram L , Parajuli Surya , Jha Rajneesh 
Published: June 2021

Introduction: Hypertension is the most common cardiovascular diseases. In only 5-10 % of hypertensive patients, underlying cause can be identified (secondary hypertension). Serum uric acid is thought to play a pathogenic role in development of hypertension and is also a commonly associated condition in patients with hypertension. Management of hyperuricemia will ultimately help in reducing cardiovascular morbidity and mortality.
Objectives: To determine the prevalence of hyperuricemia among hypertensive patients atiending Birat Medical College Teaching Hospital and also to find association between hyperuricemia and socio-demographic variables.
Methodology: This was a descriptive hospital based cross-sectional study conducted in 168 hypertensive patients at Birat Medical College Teaching Hospital, Nepal for a period of 6 months from 1 September 2020 to 28th February 2021. Sociodemographic variables were recorded and serum uric acid level was obtained based on the pre-structured questionnaires. Data were analyzed by Statistical Package for the Social Sciences version 20 (SPSS 20).
Result: Prevalence of hyperuricemia was 42 (25%) among hypertensive patients with more prevalent in male 33 (30.8%) than female 9 (14.8%). Hyperuricemia was more prevalent in patients having higher BMI and patients aged more than 60 years i.e. 38 (34.5%) and 25 (41.7%) respectively. It was more prevalent among patients with hypertension for more than 15 years 10 (41.7%) and non-vegetarian 33 (25.8%). Hyperuricemia was significantly associated with those aged more than 60 years (p=0.002) and BMI >25 kg/m2 (p=0.002).
Conclusion: Hyperuricemia was common associated condition among hypertensive patients. Hyperuricemia is mainly associated with male gender, non-vegetarian and patients with longer duration of hypertension. Similarly, it was strongly associated with older age and patients having higher BMI. Monitoring of serum uric acid and management of hyperuricemia might be helpful in management of hypertension and thus decreasing cardiovascular morbidity and mortality.
Social worker self-management as a management task
Authors: Butylina Olena , Yevdokymova Iryna 
Published: June 2021

Influence on the organizations of external factors causes the need for a set of new management methods. According to the authors, self-management can be considered an effective management technique. The article considers the essence and structure of self-management. The authors analyze self-management as a complex phenomenon that contains a set of actions and processes. Self-management has been defined as a specialist’s self-realization technology in the professional and personal space. The main components of self-management are time management skills, the ability to set priorities in work, professional and personal self-development, skills to control stressful situations, motivation to learn and professional advancement, the development of emotional intelligence. The necessity of forming self-management skills in social workers has been substantiated. In the principles of self-management, staff training has been characterized as one of the main tasks of the organization manager. The authors offer a list of management tools that can ensure the development of social workers’ skills and qualities. These include training as an active method of teaching; supervision as a mechanism of learning from the experience of others; professional training, internship, exchange of experiences, professional communication; organization of effective feedback as a mechanism for involving employees in management and increasing the level of loyalty to the organization. Organizational and managerial techniques are complemented by medical and psychological. The article concludes that social workers' self-management skills will promote the specialist's development. They will have a positive impact on his/her work quality. And they will be a means of preventing stress, professional ills and risks. Perspective areas of research have been outlined.
Decision-making technology based on knowledge engineering and experiment on the intelligent water-fertilizer irrigation system
Authors: Zhai Zhiyong , Chen Xing , Zhang Yubin , Zhou Rui 
Published: June 2021

Although the irrigation technologies based on the Decision-making System (DMS) began in the late 1990s, while being merely embryonic from laboratory research into application in the agricultural irrigation areas, DMS based on intelligent algorithms have drawn much attention from the academia over the recent years. In this study, we have provided an overview of the decision-making technology based on knowledge engineering for intelligent irrigation system referred to as Knowledge-based Engineering (KBE). As the modern technical research and scientific theory on agricultural water saving is further developed, the water-fertilizer irrigation is becoming increasingly intelligent. We have put forward the concept of KBE intelligent irrigation system and its support to decision-making in the study, while adopting the techniques and methods of knowledge engineering. In addition, we have combined our research findings with the expert knowledge on the water-fertilizer irrigation in a system integrated with computer network, intelligent reasoning and artificial intelligence (AI), among other modern high-techs. We have set up the decision-making models and analytical methods of irrigation and fertilization for KBE by referring to the expert experience and data of fertilization. Moreover, we have taken into account the web crawler technology in irrigation and fertilization, and we have put forward novel methods of knowledge acquisition based on the web crawler. Correspondingly, we have established the knowledge base for the decision-making support system tailored to irrigation and fertilization. The experiment result shows that the recommended irrigation quota is compared with local cultivation technology experience to obtain a decision accuracy of 81.7%. And the water and fertilizer management plan obtained by the intelligent decision-making system has a thicker stem and higher plant height during the growth period than the crops obtained by local cultivation experience. The output of the decision-making system is 620 kg, which a relative increase of 5.08% is compared with the 590 kg obtained from local cultivation experience.
Fatigue damage property of permeable friction courses under the water-temperature-load coupling action
Authors: Zhang Xingmei , Yang Datian , Wu Guoxiong 
Published: June 2021

In order to investigate the fatigue damage property of permeable friction courses (PFC) under the coupling action of water, temperature and load, the PFC with length of 2.93 m, width of 1.10 m and thickness of 0.04 m was prepare in the laboratory and tested by the accelerated loading testing system MMLS3. The profilometer and the portable seismic properties analyzer (PSPA) was utilized to measured the rutting depth and modulus of the whole asphalt pavement, respectively. It is found that the PFC is compaction-type rutting. In the position 200 mm, the modulus first increases and then decreases. The excess pore water pressure is not measured in pavement. The results can provide beneficial references for the design, construction and fatigue damage analysis of PFC.
An examination on ‘website accessibility’ for active engagement of visually impaired e-commerce customers
Authors: Santoki Smita , Patvardhan Neha 
Published: June 2021

BACKGROUND: The dominance of a digital wave is being felt in every sphere of the industry, and has been a big boon for online shoppers today. However, companies tend to ignore a section of their customer base, i.e. those who are visually impaired; although there are well-established standards set by WCAG 2.0 (Web Content Accessibility Guidelines). Although most e-commerce companies in India conform to these guidelines, as per the recommendations from the Indian government; however ironically; these are not accessible by the blind. OBJECTIVE: This paper specially focuses on the list of problems that the visually-impaired in India face while trying to access e-commerce sites, as most of the sites haven’t conformed to the WCAG 2.0 guidelines. METHOD: Qualitative analysis through the Repertory technique by Kelly in which, the grid developed for different constructs addressing various problems faced by such users in accessing e-commerce websites. FINDINGS: From the findings, it is evident that these visually impaired people are extremely open to gaining access towards the companies’ strategies, as they also want to be a part of the main segment of the society, and would in turn be a strong contributor to the profits of the companies, if they’re taken seriously. The findings also have a series of managerial as well as social implications. CONCLUSION: Further, the study also looks at lending some suggestions through which, marketing managers would be able to look into this prevailing problem, and thereby address the same, while enhancing their level of engagement with this specially-enabled client base. This would result not only in adding profits to the business at large, but also ensure customer satisfaction and delight, albeit the fact that they’re differently abled.
STRUCTURE OF INFORMATIONAL AND ANALYTICAL SUPPORT OF URBAN ENGINEERING ACTIVITIES IN THE SPHERE OF LAND USE PLANNING AND MANAGEMENT
Authors: Synhayivska Oleksandra , Cherednichenko Oleksandra 
Published: June 2021

Research paper "The structure of informational-analytical support of urban engineering activities in the field of land use planning and management" consists of - introduction, 6 sections, 5 infological models, conclusions, and a list of 35 sources. The object of the study are methods and models of the discipline of land use planning and management.
The subject of the research is the structure of informational support of urban planning activity, cadastral survey and expert systems.
The purpose of the paper: to develop the structure of informational and analytical support of urban planning models, and also structural and logical models of natural conditions and processes, activities and structures in the field of land use planning and management.
Area of application: information support of all types of urban planning activities. It is advisable to use the results of the work for Improvement of informational support of legislative bodies, municipal administrations and other institution responsible for urban development.
Velocidade do fluxo e pH salivar após radioterapia da região de cabeça e pescoço
Authors: Lima Antonio Adilson Soares de , Figueiredo Maria Antonia Zancanaro de , Krapf Stella Maria Rigo , Souza Fabiany Rodrigues de 
Published: June 2021

A hipossalivação é uma seqüela provocada pelo tratamento radioterápico das neoplasias malignas da região da cabeça e pescoço e esta condição predispõe o paciente às lesões de cárie e infecções bucais. Este estudo avaliou o comportamento do fluxo e pH salivar num grupo de 42 indivíduos submetidos a tratamento radioterápico com dose diária de 200cGy por aproximadamente cinco semanas. Seis amostras de saliva total foram colhidas de maneira padronizada em cada indivíduo. A primeira amostra foi obtida antes do tratamento, a segunda durante e as demais por até seis meses após o tratamento ter sido encerrado. O fluxo salivar e o pH foram determinados através de métodos laboratoriais. Ao receberem a dose de 1500cGy, período que equivaleu ao oitavo dia de tratamento, o fluxo salivar dos indivíduos diminuiu em 50% (p<0,05). Ao final do tratamento, a média observada para o fluxo foi de 0,33ml/min, o que representou uma redução de 79% (p<0,05). O pH da saliva também diminuiu em função do tratamento radioterápico. A média do pH registrada antes do tratamento foi de 7,6 que diminuiu e manteve-se em 6,8 por até seis meses após o tratamento radioterápico (p<0,05). Estes resultados demonstraram que a radioterapia quando aplicada na região da cabeça e do pescoço provoca uma redução progressiva no fluxo e pH salivar em função do tempo.
Analisis Daya Saing dan Faktor yang Mempengaruhi Volume Ekspor Biji Kopi Indonesia Ke Jepang
Authors: Novariani Cindi , Muchtolifah Muchtolifah , Sishadiyati Sishadiyati 
Published: June 2021

Indonesia is one of the developing countries in the world with abundant availability of natural resources, one of which is coffee bean commodities. Overproduction will be a benefit if the commodity can be exported mainly to developed countries, one of which is Japan. This study aims to analyze how much competitiveness value of Indonesian coffee bean commodities and factors that affect the volume of Indonesian coffee bean exports to Japan. This study used secondary data with a period of 12 years in the period 2008-2019. The Revealed Comparative Advantage (RCA) method is used to analyze the competitiveness of coffee beans as well as the Double Linear Regression Analysis with the Ordinary Least Square (OLS) model used to analyze the influence of coffee bean production, exchange rates and international prices of coffee on the volume of coffee bean exports to Japan. The results of the study found that during the period 2008-2019 the value of Indonesian coffee beans RCA has a strong competitiveness because it has a value of more than 1; partial production of coffee beans does not affect the export volume of coffee beans while the exchange rate and international price of coffee partially negatively affects the volume of Indonesian coffee beans exports to Japan.
Сombating unfair registrations and using means of individualization in the conditions of digital transformation
Authors: Androshchuk Hennadii 
Published: June 2021

Key words: intellectual property, unfair competition, means of individualization, valuation,squatter, losses, digital transformation, artificial intelligence
The article examines the economic, legal and institutional aspects of combating unfair registration and useof means of individualization (trademarks, brand names, geographical indications,domain names) in the context of digital transformation. The formation of theoreticaland methodological and methodological foundations for the protection of the rights oftheir owners, improving the efficiency of experts of intellectual property agencies, lawenforcement agencies, tools for digital search and use of artificial intelligence (AI) toensure the effectiveness of the institution of individualization. The economic and legalaspects of foreign (in the jurisdictions of China, USA, EU) and domestic legislativeand law enforcement practices to combat the phenomenon of unfair registration anduse of personalization, digital search tools and the use of AI are analyzed. It is shownthat over the next five years, 30 to 50% of product searches will be by voice ratherthan text, so the impact of AI on the way a product is purchased will have significanteconomic and legal implications for individualization legislation. The means of counteractingunscrupulous applicants in the USA have been studied. The U.S. Patentand Trademark Office (USPTO) has developed rules under which foreign applicantsand trademark owners must be represented by a U.S. licensed attorney when filingtrademark applications with the USPTO. Emphasis is placed on the introduction oflegislative liability of e-commerce platforms for counterfeit goods. The analysis of thelast changes in the legislation of Ukraine on protection of trade marks is carried out.It is shown that the new rules change the approaches to registration and protection oftrademarks, create the possibility of their fair use. Digitalization, transition to e-documentcirculation in the Customs Register, improvement of the procedure for destructionof counterfeit goods are important anti-corruption steps in the activities ofUkrainian customs in the context of digital transformation of the economy.
Bioinformatic Analyses Identify a Prognostic Autophagy-Related Long Non-coding RNA Signature Associated With Immune Microenvironment in Diffuse Gliomas
Authors: Xu Shengchao , Tang Lu , Liu Zhixiong , Yang Kui , Cheng Quan 
Published: June 2021

BackgroundAutophagy and long non-coding RNA (lncRNA) play a critical role in tumor progression and microenvironment. However, the role of autophagy-related lncRNAs (ARLs) in glioma microenvironment remains unclear.MethodsA total of 988 diffuse glioma samples were extracted from TCGA and CGGA databases. Consensus clustering was applied to reveal different subgroups of diffuse gliomas. Kaplan-Meier analysis was used to evaluate survival differences between groups. The infiltration of immune cells was estimated by ssGSEA, TIMER, and CIBERSORT algorithms. The construction of ARL signature was conducted using principal component analysis.ResultsConsensus clustering revealed two clusters of diffuse gliomas, in which cluster 1 was associated with poor prognosis and enriched with malignant subtypes of gliomas. Moreover, cluster 1 exhibited high apoptotic and immune characteristics, and it had a low purity and high infiltration of several immune cells. The constructed ARL signature showed a promising accuracy in predicting the prognosis of glioma patients. ARL score was significantly elevated in the malignant subtype of glioma and the high ARL score indicated a poor prognosis. Besides, the high ARL score notably indicated low tumor purity and high infiltration of macrophages and neutrophils.ConclusionOur study developed and validated a novel ARL signature for the classification of diffuse glioma, which was closely associated with glioma immune microenvironment and could serve as a promising prognostic biomarker for glioma patients.
Associations of Lipoprotein(a) With Coronary Atherosclerotic Burden and All-Cause Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention
Authors: Xue Yuzhou , Jian Shen , Zhou Wei , Zhou Qi , Xiang Jing , Zhu Yuansong , Xiang Zhenxian , Yang Haonan , Liu Gang , Luo Suxin 
Published: June 2021

Background: The coronary atherosclerotic burden in patients with ST-segment elevation myocardial infarction (STEMI) has been identified as the main predictor of prognosis. However, the association of lipoprotein(a) [Lp(a)], a well-established proatherogenic factor, with atherosclerotic burden in patients with STEMI is unclear.Methods: In total, 1,359 patients who underwent percutaneous coronary intervention (PCI) for STEMI were included in analyses. Three prespecified models with adjustment for demographic parameters and risk factors were evaluated. Generalized additive models and restricted cubic spline analyses were used to assess the relationships of Lp(a) with Gensini scores and the no-reflow phenomenon. Kaplan–Meier curves were generated to explore the predictive value of Lp(a) for long-term all-cause mortality. Furthermore, mRNA expression levels of LPA in different groups were compared using the GEO database.Results: Patients in the highest tertile according to Lp(a) levels had an increased incidence of heart failure during hospitalization. Furthermore, patients with high levels of Lp(a) (&gt;19.1 mg/dL) had sharply increased risks for a higher Gensini score (Pfor trend = 0.03) and no-reflow (Pfor trend = 0.002) after adjustment for demographic parameters and risk factors. During a median follow-up of 930 days, 132 deaths (9.95%) were registered. Patients with high levels of Lp(a) (&gt;19.1 mg/dL) had the worst long-term prognosis (Pfor trend &lt; 0.0001). In a subgroup analysis, patients with higher Lp(a) still had the highest all-cause mortality. Additionally, the mRNA expression levels of LPA in patients with STEMI with lower cardiac function were higher than those in other groups (P = 0.003). A higher coronary atherosclerotic burden was correlated with higher LPA expression (P = 0.01).Conclusion: This study provides the first evidence that Lp(a) (at both the protein and mRNA levels) is independently associated with coronary atherosclerotic lesions and prognosis in patients with STEMI treated with PCI.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier: ChiCTR1900028516.