bluuebunny/crossref_metadata_2025_split huggingface dataset:
A well-differentiated liposarcoma of the prevertebral space: A case report
Authors: Yang Tianming , Xiao Lin , Ren Huijun 
Published: July 2021

Abstract
Liposarcoma is common in adults; however, it very rarely occurs in the retropharyngeal space, and to date, no cases of liposarcoma in the prevertebral space have been reported. A 78-year-old man presented at the Otolaryngology Department with a 1-month history of dyspnea and dysphonia. Magnetic resonance imaging of the neck reveled a retropharyngeal mass extending from the superior margin of the axis to the level of the 7thcervical vertebra. A computed tomography scan of the patient’s neck uncovered the relationship between the mass and its’ surrounding structures. Based on the above examinations, a diagnosis of retropharyngeal liposarcoma was made initially. The patient underwent transoral surgical excision with the assistance of a nasal endoscope. During surgery, the tumor was located in the prevertebral space. Combined with pathology and immunohistochemistry examinations, the diagnosis was modified to well-differentiated liposarcoma of the prevertebral space. At the 1-year follow-up, the patient was well and there was no evidence of recurrence. The long-term outcomes are not yet known. Liposarcoma of the prevertebral space may sometimes be misdiagnosed as retropharyngeal liposarcoma; however, in our view, it is not necessary to focus on differentiating between enormous retropharyngeal and prevertebral tumors. In relation to the short-term outcome, complete excision using the transoral approach with the aid of nasal endoscope may present a better choice than the cervical approach in treating these tumors, especially in old people.
Effects of Therapeutic Plasma Exchange on the Endothelial Glycocalyx in Septic Shock
Authors: Stahl Klaus , Hillebrand Uta Carola , Kiyan Yulia , Schmidt Julius , Seeliger Benjamin , Schenk Heiko , Pape Thorben , Schmidt Bernhard M. W. , Welte Tobias , Hoeper Marius M. , Sauer Agnes , Wygrecka Malgorzata , Bode Christian , Wedemeyer Heiner , Haller Hermann , David Sascha 
Published: July 2021

Abstract
Background: Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood concentrations of shedded eGC constituents might play a mechanistic role in septic organ failure. We hypothesized that therapeutic plasma exchange (TPE) against fresh frozen plasma might influence eGC related pathology.Methods: We enrolled 20 norepinephrine dependent (NE > 0.4mg/kg/min) patients with early septic shock (onset < 12h). Sublingual assessment of the eGC via sublingual sidestream darkfield (SDF) imaging was performed. Plasma eGC degradation products such as heparan-sulfate (HS) and the eGC regulating enzymes, heparanase (Hpa)-1 and Hpa-2, were obtained before and after TPE. A 3D microfluidic flow assay was performed to examine the effect of TPE on eGC ex vivo. Results were compared to healthy controls. Results: SDF demonstrated a decrease in eGC thickness in septic patients compared to healthy individuals (p=0.001). Circulating HS levels were increased more than six-fold compared to controls and decreased significantly following TPE (controls: 16.9 (8-18.6) vs. septic patients before TPE: 105.8 (30.8-143.4) μg/ml, p<0.001; vs. after TPE: 70.7 (36.9-109.5) μg/ml, p<0.001). The Hpa-2 /Hpa-1 ratio was reduced in septic patients before TPE but normalized after TPE (controls: 13.6 (6.2-21.2) vs. septic patients at inclusion: 2.9 (2.1-5.7), p=0.001; vs. septic patients after TPE: 13.2 (11.2-31.8), p<0.001). Ex vivo stimulation of endothelial cells with serum from a septic patient induced eGC damage that could be attenuated with serum from the same patient following TPE.Conclusions: Septic shock results in profound degradation of the eGC and an acquired deficiency of the protective regulator Hpa-2. TPE removed potentially injurious eGC degradation products and partially attenuated Hpa-2 deficiency. Trial registration: clinicaltrials.gov NCT04231994, retrospectively registered 18 January 2020
Characterization of Monoolein Langmuir Monolayers Spread at The Salt Solution/Air Interface
Authors: Dhopte Balaji Sopanrao , Lad V. N. 
Published: July 2021

Abstract
The Langmuir monolayer is commonly described at interfaces for an insoluble homogenous single molecular layer. Langmuir monolayers have demonstrated various issues regarding soft matters and complex fluids by forming ideal uniform two-dimensional structures over the air-water interface. This monolayer has advantages for evaluating physicochemical properties at interfaces and, for the insoluble molecules, can be applied simultaneously to the different interaction occurrences at interfaces. For this experiment, monoolein lipid was used as a spreading solvent to create a Langmuir monolayer, and five different types of salt sub-phases were applied for the physicochemical properties’ interaction studies. On the air-water interface, the surface properties of monoolein lipids were investigated for interfacial phase behaviors, using the Wilhelmy plate pressure sensor technique compression isotherm (π-A). Data and analysis were also contributed to the correspondent, precise verification of physical state behavior with the surface pressure measurements on the interfaces through the compressibility modulus and the elasticity modulus parameters on the surface. In the experiments, the interfacial activity of the monoolein lipids was found to be stable on the aqueous sub-phase, while the area per molecule over the interface did not have much impact as a sub-phase with a change in salts. The repeatability and reproducibility of tests were affirmed by the difference in the Langmuir monolayer’s particular phase transition orientation behavior and the stability of colloidal lipid dispersion. However, Langmuir monolayer formation contributes to several special groups being restructured and is found to be a more remarkable natural process for their attractive organic dynamic structural properties over the interface, but the interfacial molecular dynamics have proven to be difficult to calculate.
Economic Efficiency of Resource Recovery – Analysis of Time-Dependent Changes on Sustainability Perception of Waste Management Scenarios
Authors: Tomic Tihomir , Kremer Irma , Schneider Daniel Rolph 
Published: July 2021

Abstract
Waste management systems are modelled to provide a public waste management service and need to be able to meet environmental sustainability requirements at a cost that is acceptable to system users/citizens. Overall environmental, economic, and/or socio-economic sustainability of waste management in previous publications is done through independent analyses and comparisons of obtained results or through multicriterial ranking of different alternatives where final results do not have a meaningful physical significance and cannot be interpreted independently. At the same time, those analysis either neglect time dependant changes by focusing on moment in time, or take into account changes in some timeframe changes but report only ranking focused single-score results, thus, results neglect time-dependent developments. All of these approaches are lacking some information needed for informed decision-making and/or are difficult to understand by wider groups of people. Thus, in this study, link between economic and environmental sustainability is analysed through newly defined single-score Economic Efficiency of Resource Recovery (EERR) index that shows the specific system cost for achieving identified resource recovery, while legislation based time dependent changes are taken into account through successive analyses for legislative most important years. This approach can be used for benchmarking the overall (environmental and economic) sustainability trends, while its graphical representation enables easier presentation of sustainability results and can be used for easier comparison of possible solutions and decision-making. The results show that the quality decision-making process needs to take into account the impact of expected changes on overall sustainability and evaluate how they will affect the actual perception of used technologies. In this context, it is shown that overall changes in sustainability, in comparison to the existing perception, can significantly change, depending on which technologies the system is based on.
Land Subsidence Prediction using Recurrent Neural Networks
Authors: Kumar Sunil , Kumar Dheeraj , Donta Praveen Kumar , Amgoth Tarachand 
Published: July 2021

Abstract
In an environment, one of the natural geological hazards is land surface subsidence. There are several reasons for land subsidence among them are underground coal mining and coal fire in subsurface or deformation is primarily measured in terms of change in ground elevation values ( Z-dimension) at different time intervals at identified ground locations. All the conventional and exiting techniques have certain limitations in monitoring and predicting land surface subsidence. In this work, we predict the land subsidence for one year in the interval of twelve days on the datasets collected through a monitoring technique called Modified PSInSAR. The sample datasets contains 14 locations and 67 previous land subsidence value calculated from each location. We train and test predictive models and perform the prediction of the land subsidence using Vanilla and Stacked long short-term memories (LSTMs). Finally, we demonstrates the predicted deformation values of the 14 locations for one year.
Effect of discoid lateral meniscus on tibiofemoral joint cartilage damage in middle-aged patients
Authors: Sulaiman Yaxiaer , Li Qi , Li Jian , Chen Gang , Tang Xin 
Published: July 2021

Abstract
Purpose: To investigate the effect of discoid lateral meniscus (DLM) on cartilage damage of the medial and lateral compartments of the knee in middle-aged patients.Methods: We analyzed data from 44 patients (54 knees) with symptomatic discoid lateral meniscus (DLM group) and 30 patients (30 knees) with a non-discoid lateral meniscus tear (control group). All patients were over 40 years old. We compared the tibiofemoral angle (TFA) and cartilage injury rate between the two groups. We further classified DLM group patients based on dysmorphic features of the menisci (DLM type), presence/absence of meniscal tear, and symptom durations, then analyzed whether these parameters could affect the number of cartilage injuries in the knee medial and lateral compartments.Results: DLM group showed higher TFA values (2.18°±2.86°) than control group (0.84°±1.35°, P=0.002), and a higher occurrence of medial compartment cartilage damage (P=0.003). Within the DLM group, patients with cartilage damage showed higher BMI than those without cartilage damage (P=0.009 for medial compartment and P=0.001 for lateral, respectively). We found that having symptoms for more than 6 months was associated with cartilage damage in the lateral compartment (P=0.021), but not the medial compartment (P=0.858). Neither presence/absence of a meniscal tear, nor DLM type affected cartilage injury rate in either the medial or lateral compartment (P>0.05).Conclusion: Varus inclination caused by DLM could lead to cartilage injury in the medial compartment in middle-aged patients, but may not reduce the occurrence of chondral damage in the lateral compartment. Rather, lateral compartment chondral damage in patients with DLM was mainly related to symptom duration.
The Treatment Efficacy of Transparasacral Approach for Presacral Tumor: A Single Center Experience
Authors: Wang Min , Liu Guoliang , Zhao Linxian , He Hongyu , Li Jiannan 
Published: July 2021

Abstract
Background

Presacral tumors, also known as retrorectal tumors, locate in the presacral space and are clinically rare and the approaches for the diagnosis and treatment of presacral tumors are still deficient. The four accepted surgical approaches for presacral tumors include transabdominal approach, sacrococcygeal approach, perineal approach, and combined approach. This study aims to evaluate the treatment efficacy of transparasacral approach for presacral tumors.
Methods

23 patients (7 males and 16 females) who are diagnosed with presacral tumors and receive surgery in transsacral approach at our department were chosen. The gender, age, body mass index (BMI), and clinical symptoms were recorded. The clinical data, postoperative complications, and short and long-term rehabilitation data were recorded and analyzed.
Conclusions

The surgery was performed smoothly and the patients recovered well without signs of intestinal fistula, abdominal and pelvic infection, lung infection, organ dysfunction, or organ failure. The incision edema occurred in only one patient. In terms of the histopathological types, presacral tumors can be classified into tailgut cyst (n = 10), epidermoid cyst (n = 5), teratoma (n = 3), and lipoma (n = 10). One patient diagnosed with tailgut cyst was accompanied by adenocarcinoma transition. Tumor recurrence didn’t occur in any patients. In addition, no patients complained about dysuria, sacrococcygeal sensory disturbance, or sacrococcygeal and perineal discomfort. Surgical resection with transparasacral approach is effective for the treatment of presacral tumors with the advantages of high safety, good treatment efficacy, few complications, good oncological prognosis, and fast recovery.
An Empirical Study towards dealing with Noise and Class Imbalance issues in Software Defect Prediction
Authors: PANDEY SUSHANT KUMAR , Tripathi Anil Kumar 
Published: July 2021

Abstract
The quality of the defect datasets is a critical issue in the domain of software defect prediction (SDP). These datasets are obtained through the mining of software repositories. Resent studies claims over the quality of the defect dataset. It is because of inconsistency between bug/clean fix keyword in fault reports and the corresponding link in the change management logs. Class Imbalance (CI) problem is also a big challenging issue in SDP models. The defect prediction method trained using noisy and imbalanced data leads to inconsistent and unsatisfactory results. Combined analysis over noisy instances and CI problem needs to be required. To the best of our knowledge, there are insufficient studies that have been done over such aspects. In this paper, we deal with the impact of noise and CI problem on five baseline SDP models; we manually added the various noise level (0 to 80%) and identified its impact on the performance of those SDP models. Moreover, we further provide guidelines for the possible range of tolerable noise for baseline models. We have also suggested the SDP model, which has the highest noise tolerable ability and outperforms over other classical methods. The True Positive Rate (TPR) and False Positive Rate (FPR) values of the baseline models reduce between 20\% to 30\% after adding 10% to 40% noisy instances. Similarly, the ROC (Receiver Operating Characteristics) values of SDP models reduces to 40% to 50%. The suggested model leads to avoid noise between 40% to 60% as compared to other traditional models.
Optical 8PSK Modulation Format Generator Basedon Three Microring Modulators
Authors: Singha Satyabrata , Bhowmik Sanjukta , Sinha Nitish , Bhowmik Bishanka Brata 
Published: July 2021

Abstract
We have proposed an 8PSK modulator based on three microring modulators (MRM). The design consists of three MRMs, each with a radius of 11.1μm. Of these three, two MRMs are connected in parallel and they together generate a QPSK (Quadrature phase shift keying) signal. While at the output port of the QPSK, a third MRM is connected in series works as an angle modulator, which is basically a 45o phase shift modulator; i.e., the output of the MRM varies by 45o depending on the bit pattern fed to it, ’0’or ’1’ respectively. In the result section, we have simulated and shown the performance of the proposed 2.5 GBaud 8PSK modulator after transmitting the modulated signal through various lengths of optical fiber. The bit error rate (BER) vs. optical signal to noise ratio (OSNR) curve shows that, 10−3BER has been achieved at 13.5dB OSNR.
CBD: A New Divergence Measure for Complex Mass Function and its Application in Pattern Recognition
Authors: Luo Lan , Xiao Fuyuan 
Published: July 2021

Abstract
The theory of complex mass function is an effective method to deal with uncertainty information, and it is a generalized of Dempster-Shafer evidence theory. However, divergence measure is still an open issue in the realm of complex mass function theory. The main contribution of our paper is to propose a generalized divergence measure for complex mass function that is called complex belief divergence (CBD),which has the properties of symmetry, nonnegativity, nondegeneracy. When complex mass function degenerates into classical mass function, the CBD will degenerate into classical belief divergence, which has a better ability to measure uncertainty of information. Finally, a pattern recognition algorithm based on CBD is designed and applied to a medical diagnosis problem, which proves its practical prospect.
Cumulative Live Birth Rates of Women ≥ 38 Years With Poor, Normal and High Ovarian Response
Authors: Liu Conghui , Li Yu , Jiang Hong , Wang Xuemei , Ni Feng , Liu Ying 
Published: July 2021

Abstract
Background
Previous studies have reported that live birth rate (LBR) decreased with aging, however, no study has evaluated the cumulative LBR (CLBR) in accordance with the ovarian response in advanced maternal age (AMA) patients. This study aims to investigate the relationship between the ovarian response and the CLBR in AMA patients.
Methods
913 women ≥ 38 years underwent in vitro fertilization (IVF) and fresh embryo transfer (ET) between January 2014 and June 2019 were enrolled in this retrospective study. All subjects were categorized into three groups, poor ovarian response (POR) group: 1–3 oocytes retrieved (n = 127), normal ovarian response (NOR) group: 4–15 oocytes retrieved, and high ovarian response (HOR) group: more than 15 oocytes retrieved. The primary outcome was the CLBR in one oocyte retrieval cycle after transfer of all fresh and frozen embryos. Logistic regression models were used to derive the odds ratio (OR) to identify the relationship of CLBR with different ovarian response, adjusting for age and body mass index.
Results
Compared with women in POR group, the women in other groups (NOR and HOR groups) achieved higher CLBR [adjusted OR (aOR) = 2.12, 95% confidence interval (CI), 1.16–4.38 for NOR group; aOR = 2.93, 95% CI, 1.44–5.97 for HOR]. The LBR of the fresh ET and the neonate characteristics showed no significant difference among the three groups.
Conclusion
Ovarian response is significantly associated with CLBR in women with advanced age.
Impact of Hemolysis on Multi-OMIC Pancreatic Biomarker Discovery: Derisking Precision Medicine Biomarker Development
Authors: Searfoss Richard , Shah Punit , Ofori-Mensa Kennedy , Bussberg Valerie , Tolstikov Vladimir , Greenwood Bennett , Li Hongyan , DeCicco Corinne , Granger Elder , Rodrigues Leonardo O. , Grund Eric M. , Moser A. James , Sarangarajan Rangaprasad , Narain Niven R. , Kiebish Michael A. 
Published: July 2021

Abstract
Cancer biomarker discovery is critically dependent on the integrity of biofluid, and tissue samples acquired from study participants. Multi-omic profiling of candidate protein, lipid, and metabolite biomarkers is confounded by timing and fasting status of sample collection, participant demographics and treatment exposures of the study population. Contamination by hemoglobin, whether caused by hemolysis during sample preparation or underlying red cell fragility, contributes 0–10 g/L of extraneous protein to plasma, serum, and Buffy coat samples and may interfere with biomarker detection and validation. We analyzed 617 plasma, 701 serum, and 657 buffy coat samples from a 7 year longitudinal multi-omic biomarker discovery program evaluating 400 + participants with or at risk for pancreatic cancer, known as Project Survival™. Hemolysis was undetectable in 93.1% of plasma and 95.0% of serum samples, whereas only 37.1% of Buffy coat samples were free of contamination by hemoglobin. Regression analysis of multi-omic data demonstrated a statistically significant correlation between hemoglobin concentration and the resulting pattern of analyte detection and concentration. Although hemolysis had the greatest impact on identification and quantitation of the proteome, distinct differentials in metabolomics and lipidomics were also observed and correlated with severity. We conclude that quality control is vital to accurate detection of informative molecular differentials using OMIC technologies and that caution must be exercised to minimize the impact of hemolysis as a factor driving false discovery in large cancer biomarker studies.
A Pilot Study on Home Range and Habitat Use of Chinese Goral (Naemorhedus Griseus): Exploring GPS Tracking Data in Cliff Landscape by Three Estimation Methods
Authors: Teng Yang , TANG Shupei , Menghe Dalai , Wu Liji , HAN Zhiqing , HAN Yingying , BAO Weidong 
Published: July 2021

Abstract
Home range size estimation is a crucial basis for developing effective conservation strategies and provides important insights into animal behavior and ecology. This study aimed at analyzing the home range variations, the influence of altitude in habitat selection, and comparing three methods in home range estimation of Chinese gorals (Naemorhedus griseus) living at a cliff landscape. The results indicated that there were significant differences between the annual home range sizes of individual animals but there was no difference in their seasonal home range sizes based on GPS tracking data of five female Chinese gorals from February 2015 to September 2018. The monthly home ranges decreased dramatically in May, June and July due to birth-giving. Notable seasonal variations were found in the micro-habitats of the Chinese gorals, as reflected by the altitude they inhabit, with higher altitude habitats used in spring and lower altitude habitats used in winter. Additionally, the altitude of monthly habitats was lowest in January, which may indicate an adaptation to low air temperature. We also found differences between estimation methods, namely minimum convex polygon (MCP), kernel density estimation (KDE) and α-local convex hull (α-LoCoH), with seasonal home range sizes derived from α-LoCoH being substantially smaller than those derived from MCP and KDE. In conclusion, our findings filled the gaps in home range study for this endangered species and contributed to effective conservation strategies. Considerations shall have to be given to the variations in home range estimation caused by different methods when dealing with rugged habitats, so as to make sure that any interpretation concerning the habitat use of the targeted species made on basis of such results would be meaningful and valid.