bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of bridging therapy prior to CD19‐directed chimeric antigen receptor T‐cell therapy in patients with large B‐cell lymphoma
Authors: Lutfi Forat , Holtzman Noa G. , Kansagra Ankit J. , Mustafa Ali Moaath , Bukhari Ali , Yan Jingsheng , Samanta Santanu , Gottlieb David , Kim Dong W. , Matsumoto Lisa R. , Gahres Natalie , Ruehle Kathleen , Hankey Kim G. , Douglas Tracy , Lee Seung T. , Law Jennie Y. , Kocoglu Mehmet H. , Atanackovic Djordje , Yared Jean A. , Hardy Nancy M. , Molitoris Jason , Mohindra Pranshu , Rapoport Aaron P. , Dahiya Saurabh 
Published: September 2021

SummaryIn the relapsed/refractory setting for treatment of large B‐cell lymphoma (LBCL), chimeric antigen receptor T‐cell (CAR‐T) therapy has emerged as an effective treatment modality. Patients often have aggressive disease that requires prompt treatment in the form of bridging therapy (BT) for disease stabilisation while CAR‐T cells are manufactured. Patients (n = 75) undergoing CAR‐T therapy infusion for LBCL at our institution were identified. A total of 52 (69·3%) received BT and 23 (30·7%) received no BT (NBT). BT modalities included systemic BT (SBT) in 28 patients, radiation BT (RBT) in 14, and high‐dose steroid BT (HDS) in 10. There was no difference in incidence of cytokine release syndrome or immune effector cell‐associated neurotoxicity syndrome between BT and NBT (P = 0·18 and P = 0·53 respectively). Prolonged cytopenias at Day 180 were more common in BT than NBT (50% vs. 13·3%, P = 0·04). The SBT and RBT subgroups had more cytopenias at Day 180 compared to the HDS and NBT subgroups (58·3% and 57·1% vs. 20% and 13·3% respectively, P = 0·04). Disease response at last follow‐up, progression‐free survival and overall survival were similar between BT, NBT, and BT subgroups. In summary, BT can be safely considered in patients undergoing CAR‐T therapy. However, those undergoing BT with SBT or RBT are at higher risk of prolonged cytopenias after CAR‐T therapy.
The biochemical diagnosis of adrenal insufficiency with modern cortisol assays: Reappraisal in the setting of opioid exposure and hospitalization
Authors: Colling Caitlin , Nachtigall Lisa , Biller Beverly M. K. , Miller Karen K. 
Published: September 2021

AbstractObjectiveWe aimed to (1) examine the diagnosis of opioid‐induced adrenal insufficiency, and (2) investigate the diagnostic value of a morning cortisol <83 nmol/L (3 µg/dl) for the diagnosis of adrenal insufficiency, using newer more specific cortisol assays and cut‐offs.DesignRetrospective study (5/2015–10/2020).ParticipantsCohort 1 (N = 75): adults who underwent cosyntropin stimulation testing and opioid exposure for >30 days. Cohort 2 (N = 854): adults, with or without opioid exposure, who had a morning cortisol level measured the same day as stimulation testing.MeasurementsPeak cortisol during cosyntropin stimulation testing. Sensitivity and specificity of morning serum cortisol for adrenal insufficiency.ResultsThe prevalence of adrenal insufficiency in patients with chronic opioid exposure who underwent cosyntropin stimulation testing was 4.0% using a cortisol cutoff of <405 nmol/L (14.7 µg/dl) versus 19% using the traditional cutoff of <500 nmol/L (18.1 µg/dl). For hospitalized patients with and without opioid‐exposure, 14 of 22 (64%) patients with morning cortisol levels of <83 nmol/L (3 µg/dl) passed cosyntropin stimulation testing. A morning cortisol level of <348 nmol/L (12.6 µg/dl) had 100% sensitivity (95% confidence interval: 84.5%–100%) for the diagnosis of adrenal insufficiency.ConclusionApplying a cutoff of <405 nmol/L (14.7 µg/dl), opioid‐induced adrenal insufficiency is rare. Nearly 1 out of 6 patients would be reclassified as having adrenal insufficiency applying the guideline‐recommended cutoff of <500 nmol/L (18.1 µg/dl). Serum morning cortisol <83 nmol/L (3 µg/dl) is not a valid diagnostic test for adrenal insufficiency in hospitalized patients, whether or not receiving opioids.
Better off alone? Comparing the substance use, mental health and trauma risks of youth alcohol and other drug service users either living in out of home care, living with parents or experiencing homelessness
Authors: Hallam Karen T. , Fernandes Marilia , Pavlis Alexia 
Published: September 2021

AbstractIntroductionAll young people seeking assistance from youth alcohol and other drug services require support to help them minimise the harms from their substance use and continue to develop healthy and meaningful lives. A particular focus on young people in residential out of home care (OoHC) highlights the increased risks of substance use, mental health issues and continued vulnerabilities in this group. While in the past, research contrasted this group with young people living at home, this study contrasted young people in OoHC with homeless youths alongside those living with parents.MethodsThe research contrasted these three groups of young people on substance use profiles, mental health and wellbeing and vulnerability to abuse (historic and current) in the Youth Needs Census conducted in Victoria and Queensland over 2013–2017.ResultsThe results demonstrate a clear risk of increased casual and daily methamphetamine use in the homeless youth group and occasional heroin use in the OoHC group. Mental health measures for both the OoHC and homeless youths were worse than the young people living at home. Trauma was similarly higher in these groups, with both historical and ongoing risks of violent crime for homeless youths.Discussion and ConclusionsThe results demonstrate the similar and serious health and wellbeing risks facing both youths in residential OoHC and homeless youths. These results are concerning as one of these groups is ostensibly in the care of the community and government, while the other group is experiencing unstable accommodation and associated physical risks.
Combining virtual reality and 3D‐printed models to simulate patient‐specific dental operative procedures—A study exploring student perceptions
Authors: Towers Ashley , Dixon Jonathan , Field James , Martin Rachel , Martin Nicolas 
Published: September 2021

AbstractIntroductionStudents face a number of challenges in translating the skills acquired in pre‐clinical simulation environments to the delivery of real patient care. These are particularly emphasised for complex operative procedures such as tooth preparations for indirect restorations. This paper reports student perceptions of a novel approach designed to improving student confidence when undertaking operative procedures on patients for the first time, by providing patient‐specific simulation using virtual reality (VR) and 3D‐printed models of the student's real clinical case.Materials and MethodsStudents practised on patient‐specific models, in the presence of a clinical tutor, firstly using VR simulation then with 3D‐printed models in a clinical skills laboratory. The students then carried out the operative procedure on their patients, on the third occasion of practice. After providing the treatment for their patients, students attended a semi‐structured interview to discuss their experiences. The qualitative data were analysed using two forms of inductive analysis.ResultsStudents most frequently cited: the value of the educator, increased confidence and efficiency during the clinical procedure, improved patient confidence and the complementary benefits of the two simulation modalities.Thematic analysis of participants' responses uncovered five key themes:

The value of virtual reality dental simulators

The value of clinical skills laboratory simulation with 3D‐printed models

The value of educator engagement

The impact on the clinical procedure and the patient

The VR and clinical skills laboratory balance

ConclusionThis paper reports the early findings of an intervention that improves dental student confidence through the use of patient‐specific VR exercises and 3D‐printed models. These provided an incremental learning experience for an operative clinical procedure, prior to treatment of the live patient. Early results suggest this is a positive experience for the students, providing a valuable contribution to their confidence and preparedness.
Hybridity and conflicting logics—and what if not? A historical exploration of a XIV–XVI century social entity in Venice
Authors: Lusiani Maria , Pancot Chiara , Vedovato Marco 
Published: September 2021

AbstractThis paper sets out to explore how hybrid organizations managed their established institutional complexity in the past, and what place was there for accounting in this endeavor. The paper draws on a historical case study of how a social entity operated in 14th–16th‐century Venice. Ca’ di Dio, a hospice providing hospitality and care to poor women, is what today we would call a “hybrid organization,” in that it was born at the crossroads of ecclesiastic and public jurisdictions, it was autonomously administered, self‐financed through commercial activities, but operated within the public control of the State. It will be found that Ca’ di Dio worked within a complex arrangement of multiple logics, that these logics coexisted without particular tension or conflict, and that accounting was a central practice to manage Ca’ di Dio activities, despite its noncommercial nature. The paper thus, while contributing to documenting the presence of hybrid organizations in the past, also questions the presupposed tension and conflict in logics that these organizations are thought to come with. Finally, it also documents the trivial, but overlooked, role of accounting as primarily a calculative tool for everyday management in hybrid organizations.
Gabapentinoid use in French most precarious populations: Insight from Lyon Permanent Access to Healthcare (PASS) units, 2016—1Q2021
Authors: Chappuy Mathieu , Nourredine Mikail , Clerc Bertrand , Fahmi Morgan , Misslin Pauline , Berthier Maude , Laloi Louise , Rolland Benjamin 
Published: September 2021

AbstractBackgroundGabapentinoids (i.e., gabapentin and pregabalin) are medications approved for epilepsy, chronic pain, or generalized anxiety disorder. Recently, there have been regular reports of misuse of pregabalin, and to a lesser extent, gabapentin, in particular among opioid and polydrug users.ObjectivesTo longitudinally explore the amounts of gabapentinoids dispensed in Lyon's Permanent Access to Healthcare (PASS) units, which offer permanent and free healthcare to precarious populations with no healthcare insurance coverage.MethodsWe collected the amounts of pregabalin and gabapentin dispensed in the three PASS units of Lyon and calculated the average doses dispensed monthly between 2016 and the first quarter of 2021 (1Q2021), with and without adjustment for the number of dispensing visits.ResultsThe total doses of gabapentinoid dispensed every month in Lyon's PASS units displayed a 1233% increase for pregabalin, and a 1185% increase for gabapentin, between 2016 and 1Q2021. When adjusted for the number of visits, this increase reached a factor of 8.5 for pregabalin and 8.3 for gabapentin, respectively. However, while the increase in pregabalin dispensing was constant throughout the study period, gabapentin total dispensed doses were more fluctuating over time, and the rise of dispensations was thus less straightforward.ConclusionOur study reveals a local but substantial increase in gabapentinoid use in populations with no social insurance. These findings should be confirmed more widely and plead for the systematic collection of anonymous patient data in free healthcare centers in France.
Data‐driven bioregionalization: A seascape‐scale study of macrobenthic communities in the Eurasian Arctic
Authors: Pantiukhin Dmitrii , Piepenburg Dieter , Hansen Miriam L. S. , Kraan Casper 
Published: September 2021

AbstractAimWe conduct the first model‐based assessment of the biogeographical subdivision of Eurasian Arctic seas to (1) delineate spatial distribution and boundaries of macrobenthic communities on a seascape level; (2) assess the significance of environmental drivers of macrobenthic community structures; (3) compare our modelling results to historical biogeographical classifications; and (4) couple the model to climate scenarios of environmental changes to project potential shifts in the distribution and composition of macrobenthic communities by 2100.LocationEurasian Arctic seas, in particular Barents, Kara and Laptev Seas.Taxon169 species of macrobenthic fauna; most common taxa are Polychaeta (85 species), Malacostraca (30 species), Bivalvia (26 species) and Gastropoda (10 species).MethodsWe employed the Region of Common Profile (RCP) approach to assess the bioregionalization patterns of Eurasian Arctic seafloor communities. The RCP approach allows the identification of seascape‐scale distribution patterns by simultaneously considering biotic and environmental data within one modelling step.ResultsFour RCPs were identified within the Eurasian Arctic. The results showed that water depth, sea‐ice cover, bottom‐water temperature and salinity, proportion of fine sediments, particulate organic carbon (POC) and depth of the euphotic zone were among the most important driving variables of macrobenthos communities. The projections, driven by the climate‐change scenarios, suggested a general north‐eastward shift of the RCPs over the 21st century, mainly correlated with retreating sea‐ice and increasing sea‐bottom temperature.Main conclusionsThe identified RCPs largely match the previously reported large‐scale distribution patterns of macrobenthic communities in Eurasian Arctic seas. The spatio‐temporal dynamics of RCPs are in agreement with local long‐term observation data on macrobenthic resilience/vulnerability in the studied region. The representation of the ecoregions and biotas in a probabilistic form, together with quantitative assessment of potential climate‐driven changes, will help to adequately consider macrobenthic biodiversity dynamics in the development of science‐based conservation measures.
Truly ubiquitous CRESS DNA viruses scattered across the eukaryotic tree of life
Authors: Zhao Lele , Lavington Erik , Duffy Siobain 
Published: September 2021

AbstractUntil recently, most viruses detected and characterized were of economic significance, associated with agricultural and medical diseases. This was certainly true for the eukaryote‐infecting circular Rep (replication‐associated protein)‐encoding single‐stranded DNA (CRESS DNA) viruses, which were thought to be a relatively small group of viruses. With the explosion of metagenomic sequencing over the past decade and increasing use of rolling‐circle replication for sequence amplification, scientists have identified and annotated copious numbers of novel CRESS DNA viruses – many without known hosts but which have been found in association with eukaryotes. Similar advances in cellular genomics have revealed that many eukaryotes have endogenous sequences homologous to viral Reps, which not only provide ‘fossil records’ to reconstruct the evolutionary history of CRESS DNA viruses but also reveal potential host species for viruses known by their sequences alone. The Rep protein is a conserved protein that all CRESS DNA viruses use to assist rolling‐circle replication that is known to be endogenized in a few eukaryotic species (notably tobacco and water yam). A systematic search for endogenous Rep‐like sequences in GenBank's non‐redundant eukaryotic database was performed using tBLASTn. We utilized relaxed search criteria for the capture of integrated Rep sequence within eukaryotic genomes, identifying 93 unique species with an endogenized fragment of Rep in their nuclear, plasmid (one species), mitochondrial (six species) or chloroplast (eight species) genomes. These species come from 19 different phyla, scattered across the eukaryotic tree of life. Exogenous and endogenous CRESS DNA viral Rep tree topology suggested potential hosts for one family of uncharacterized viruses and supports a primarily fungal host range for genomoviruses.
A meta‐analysis of the executive function components inhibition, shifting, and attention in intellectual disabilities
Authors: Spaniol M. , Danielsson H. 
Published: September 2021

AbstractBackgroundExecutive function is a concept for higher‐order cognitive functions, which have the role of controller and modulator of cognitive abilities. The consensus in the literature is that people with an intellectual disability perform significantly lower on executive function tasks than groups matched on chronological age. The comparison with groups matched on mental age is less clear. Therefore, the objective of this meta‐analysis was to investigate to what extent executive function is impaired in people with intellectual disability compared with a typically developing control group matched on mental age. It was also investigated if the executive function component and intellectual disability aetiology moderated the effect.MethodsEligibility criteria were participants with intellectual disability (IQ ≤ 75) without a dual diagnosis; a comparison group matched on mental age; executive function outcome reported in a group comparison study design with n ≥ 10. Working memory tasks and ratings of executive function were not included. The literature search yielded 6637 potentially interesting articles. Twenty‐six studies (with 99 effect sizes) including 1395 participants were included in the quantitative synthesis.ResultsA multilevel random‐effects meta‐analysis found that people with intellectual disability performed statistically significantly lower than the mental age‐matched group on the executive function tasks, g = −0.34, 95% confidence interval = [−0.53, −0.16]. However, the heterogeneity between effect sizes was large. The intellectual disability aetiology moderator was significant, but it only reduced the heterogeneity marginally.ConclusionThe overall conclusion is that individuals with an intellectual disability have more problems with executive function tasks than mental age‐matched controls. Limitations are the large unexplained variance and the remarkably high number (69) of different tests that were used, which make more detailed conclusions problematic. This meta‐analysis implies that future studies need to be of better quality, to have higher power, and to a higher degree use the same executive function tests.
The impact of physical pain and depression on sleep quality in older adults with chronic disease
Authors: Tsai Li‐Chuan , Chen Shu‐Ching , Chen Yen‐Chin , Lee Li‐Yun 
Published: September 2021

AbstractAims and objectivesThis study's purpose was to identify the correlates of sleep quality in older adults with chronic disease.BackgroundSleep quality is a common problem in older adults that may be affected by physical and mental status.DesignA cross‐sectional correlational design was employed.MethodsThe study was conducted between July 2019 and April 2020 in a teaching hospital of southern Taiwan. The Geriatric Depression Scale, Pittsburgh Sleep Quality Index and Numerical Rating Scale were used to assess depression, sleep quality and physical pain respectively.ResultsOf the 120 older adults (age >65 years) with chronic disease, the average Pittsburgh Sleep Quality Index score was 5.67. A total of 45.8% subjects had sleep disturbance. Older adults who were living with a partner and those who urinated at night were significantly more likely to report sleep disturbance. The presence of sleep disturbance was associated with greater levels of depression and higher levels of physical pain.ConclusionLiving with a partner, nocturia, physical pain and depression were associated with the presence of sleep disturbance in older adults with chronic disease.Relevance to clinical practiceThe results of this study can help healthcare providers understand the factors associated with sleep disturbance in older adults with chronic disease, thereby facilitating the early resolution of sleep disturbance issues in this population.
Adherence to lifestyle modifications and its associated factors in hypertensive patients
Authors: Dhakal Amrita , K.C. Takma , Neupane Mahesh 
Published: September 2021

AbstractAims and objectivesTo find out the adherence to lifestyle modifications and its associated factors in hypertensive patients.BackgroundLow adherence to lifestyle modifications leads to poor therapeutic effectiveness, decreased quality of life, poor health outcomes and increased health care costs. Various factors play an important role in determining the adherence level varying among the different cultural, social and national contexts.DesignA cross‐sectional analytical research design was carried out.MethodsInformation from 264 patients with hypertension was collected at the Outpatient Department of Manmohan Cardiothoracic, Vascular and Transplant Center, Kathmandu. A standard tool of WHO Steps Survey Questionnaire and Hypertension Fact Questionnaire was used for data collection. Chi‐square test and binary logistic regression were used for analysis using SPSS 16.ResultThe overall adherence to lifestyle modifications was determined as 20.8% with the adherence rate being lowest up to 30.3% for adequate intake of fruits and vegetables. Likewise, 52.5% of patients had average knowledge of hypertension management. Age (p = .021), education (p = .001), occupation(p = .026), household income (p = .007) and family history(p = .011) had statistically significant association with the level of adherence. Younger age (AOR = 1.85 CI = 0.79–4.33) remained as the independent predictor of high adherence to lifestyle modifications. The study followed the STROBE checklist for reporting cross‐sectional study.ConclusionThis study identified that adherence to lifestyle modification is low in older patients. More effective lifestyle modification counselling and educational approaches focusing on the older age groups as well as considering educational level, occupation, family income and family history of hypertension are required to improve their level of adherence.Relevance to clinical practiceNurses are frequently acquainted with the hypertensive patients in hospitals where they need to provide health teaching on lifestyle modifications. This study identifies the factors that need to be considered while counselling the hypertensive patients.