bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of half-turned truncal switch and conventional operations
Authors: Hongu Hisayuki , Yamagishi Masaaki , Maeda Yoshinobu , Itatani Keiichi , Asada Satoshi , Fujita Shuhei , Nakatsuji Hiroki , Yaku Hitoshi 
Published: January 2021

Abstract

OBJECTIVES
To compare conventional procedures with the half-turned truncal switch operation (HTTSO) for the management of complete transposition of the great arteries with left ventricular outflow tract (LVOT) obstruction using time-resolved 3-dimensional magnetic resonance phase-contrast imaging.

METHODS
We identified 2 cases that underwent the Rastelli procedure and one case that underwent the Réparation a l'étage ventriculaire before 2002 [conventional procedures group (group C)], and 16 cases of HTTSO that were performed between 2002 and 2020 [HTTSO group (group H)]. Postoperative haemodynamics were assessed using time-resolved 3-dimensional magnetic resonance phase-contrast imaging in cases in both groups.

RESULTS
The median follow-up period was 20.4 years in group C, and 6.1 years in group H. In group C, all 3 patients underwent reoperation because of postoperative right ventricular outflow tract obstruction and/or insufficiency. In addition, permanent pacemaker implantation was needed in 1 patient because of complete atrioventricular block complicated by ventricular septal defect enlargement. In group H, reoperation for LVOT/right ventricular outflow tract obstruction was not needed. A time-resolved 3-dimensional magnetic resonance phase-contrast imaging examination revealed high energy loss and wall shear stress in the winding LVOT in the group C. In contrast, low energy loss and wall shear stress, with straight and smooth LVOT, were identified in group H.

CONCLUSIONS
HTTSO was shown to be superior to conventional procedures because a straight and wide LVOT could be obtained. Therefore, HTTSO should be the first choice for complete transposition of the great arteries with LVOT obstruction.
Role Theory, Foreign Policy, and the Social Construction of Sovereignty: Brexit Stage Right
Authors: Beasley Ryan K , Kaarbo Juliet , Oppermann Kai 
Published: January 2021

Abstract
The international roles states play in world politics are bound up with the ways in which sovereignty is constructed within the international system. While scholarship on sovereignty has recognized its social construction, and role research emphasizes social interactions as shaping roles and role behaviors, little work has explored the relationship between sovereignty and roles. Linking roles and sovereignty offers a distinct perspective on the social construction of sovereignty, providing a broad conception of socialization, emphasizing agency, and bridging domestic politics and international relations. We develop the concept of a “sovereignty–role nexus” through an examination of Brexit, revealing, through processes of role contestation and role socialization, multiple and competing constructions of the nature and value of sovereignty. While Brexit is unique, we suggest that these dynamics will affect other cases where states face role changes linked to sovereignty concerns.
Comparison of an oncology clinical decision-support system’s recommendations with actual treatment decisions
Authors: Suwanvecho Suthida , Suwanrusme Harit , Jirakulaporn Tanawat , Issarachai Surasit , Taechakraichana Nimit , Lungchukiet Palita , Decha Wimolrat , Boonpakdee Wisanu , Thanakarn Nittaya , Wongrattananon Pattanawadee , Preininger Anita M , Solomon Metasebya , Wang Suwei , Hekmat Rezzan , Dankwa-Mullan Irene , Shortliffe Edward , Patel Vimla L , Arriaga Yull , Jackson Gretchen Purcell , Kiatikajornthada Narongsak 
Published: January 2021

Abstract

Objective
IBM(R) Watson for Oncology (WfO) is a clinical decision-support system (CDSS) that provides evidence-informed therapeutic options to cancer-treating clinicians. A panel of experienced oncologists compared CDSS treatment options to treatment decisions made by clinicians to characterize the quality of CDSS therapeutic options and decisions made in practice.

Methods
This study included patients treated between 1/2017 and 7/2018 for breast, colon, lung, and rectal cancers at Bumrungrad International Hospital (BIH), Thailand. Treatments selected by clinicians were paired with therapeutic options presented by the CDSS and coded to mask the origin of options presented. The panel rated the acceptability of each treatment in the pair by consensus, with acceptability defined as compliant with BIH’s institutional practices. Descriptive statistics characterized the study population and treatment-decision evaluations by cancer type and stage.

Results
Nearly 60% (187) of 313 treatment pairs for breast, lung, colon, and rectal cancers were identical or equally acceptable, with 70% (219) of WfO therapeutic options identical to, or acceptable alternatives to, BIH therapy. In 30% of cases (94), 1 or both treatment options were rated as unacceptable. Of 32 cases where both WfO and BIH options were acceptable, WfO was preferred in 18 cases and BIH in 14 cases. Colorectal cancers exhibited the highest proportion of identical or equally acceptable treatments; stage IV cancers demonstrated the lowest.

Conclusion
This study demonstrates that a system designed in the US to support, rather than replace, cancer-treating clinicians provides therapeutic options which are generally consistent with recommendations from oncologists outside the US.
Exploring the relationship between electronic health records and provider burnout: A systematic review
Authors: Yan Qi , Jiang Zheng , Harbin Zachary , Tolbert Preston H , Davies Mark G 
Published: January 2021

Abstract

Objective
Stress and burnout due to electronic health record (EHR) technology has become a focus for burnout intervention. The aim of this study is to systematically review the relationship between EHR use and provider burnout.

Materials and Methods
A systematic literature search was performed on PubMed, EMBASE, PsychInfo, ACM Digital Library in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Inclusion criterion was original research investigating the association between EHR and provider burnout. Studies that did not measure the association objectively were excluded. Study quality was assessed using the Medical Education Research Study Quality Instrument. Qualitative synthesis was also performed.

Results
Twenty-six studies met inclusion criteria. The median sample size of providers was 810 (total 20 885; 44% male; mean age 53 [range, 34-56] years). Twenty-three (88%) studies were cross-sectional studies and 3 were single-arm cohort studies measuring pre- and postintervention burnout prevalence. Burnout was assessed objectively with various validated instruments. Insufficient time for documentation (odds ratio [OR], 1.40-5.83), high inbox or patient call message volumes (OR, 2.06-6.17), and negative perceptions of EHR by providers (OR, 2.17-2.44) were the 3 most cited EHR-related factors associated with higher rates of provider burnout that was assessed objectively.

Conclusions
The included studies were mostly observational studies; thus, we were not able to determine a causal relationship. Currently, there are few studies that objectively assessed the relationship between EHR use and provider burnout. The 3 most cited EHR factors associated with burnout were confirmed and should be the focus of efforts to improve EHR-related provider burnout.
The impact of electronic health record–integrated patient-generated health data on clinician burnout
Authors: Ye Jiancheng 
Published: January 2021

Abstract
Patient-generated health data (PGHD), such as patient-reported outcomes and mobile health data, have been increasingly used to improve health care delivery and outcomes. Integrating PGHD into electronic health records (EHRs) further expands the capacities to monitor patients’ health status without requiring office visits or hospitalizations. By reviewing and discussing PGHD with patients remotely, clinicians could address the clinical issues efficiently outside of clinical settings. However, EHR-integrated PGHD may create a burden for clinicians, leading to burnout. This study aims to investigate how interactions with EHR-integrated PGHD may result in clinician burnout. We identify the potential contributing factors to clinician burnout using a modified FITT (Fit between Individuals, Task and Technology) framework. We found that technostress, time pressure, and workflow-related issues need to be addressed to accelerate the integration of PGHD into clinical care. The roles of artificial intelligence, algorithm-based clinical decision support, visualization format, human-computer interaction mechanism, workflow optimization, and financial reimbursement in reducing burnout are highlighted.
The use of live yeast to increase intake and performance of cattle receiving low-quality tropical forages
Authors: Parra Mariano C , Costa Diogo F A , Palma Andre S V , Camargo Karine D V , Lima Lais O , Harper Karen J , Meale Sarah J , Silva Luis F P 
Published: January 2021

AbstractThe objective was to evaluate the effects of a specific strain of live yeast (LY) on growth performance, fermentation parameters, feed efficiency, and bacterial communities in the rumen of growing cattle fed low-quality hay. In experiment (exp.) 1, 12 Droughtmaster bull calves (270 ± 7.6 kg initial body weight [BW]) were blocked by BW into two groups, allocated individually in pens, and fed ad libitum Rhodes grass hay (8.4% of crude protein [CP]) and 300 g/bull of supplement (52% CP) without (Control) or with LY (8 × 109 colony-forming unit [CFU]/d Saccharomyces cerevisiae CNCM I-1077; Lallemand Inc., Montreal, Canada) for 28 d, followed by 7 d in metabolism crates. Blood and rumen fluid were collected before feeding and 4 h after feeding. In exp. 2, for assessment of growth performance, 48 Charbray steers (329 ± 20.2 kg initial BW) were separated into two blocks by initial BW and randomly allocated into 12 pens. The steers were fed Rhodes grass hay (7.3% CP) and 220 g/steer of supplement (60% CP) without or with LY (8 × 109 CFU/d) for 42 d, after a 2-wk adaptation period. In exp. 1, fiber digestibility was calculated from total fecal collection, and, in exp 2, indigestible neutral detergent fiber (NDF) was used as a marker. Inclusion of LY increased (P = 0.03) NDF intake by 8.3% in exp. 1, without affecting total tract digestibility. No changes were observed in microbial yield or in the efficiency of microbial production. There was a Treatment × Time interaction (P &lt; 0.01) for the molar proportion of short-chain fatty acids, with LY increasing propionate before feeding. Inclusion of LY decreased rumen ammonia 4 h after feeding (P = 0.03). The addition of LY reduced rumen bacterial diversity and the intraday variation in bacterial populations. Relative populations of Firmicutes and Verrucomicrobia varied over time (P &lt; 0.05) only within the Control group. At the genus level, the relative abundance of an unclassified bacterial genus within the order Clostridiales, a group of cellulolytic bacteria, was reduced from 0 to 4 h after feeding in the Control group (P = 0.02) but not in the LY group (P = 1.00). During exp. 2, LY tended to increase average daily gain (ADG) (P = 0.08) and feed efficiency (P = 0.10), with no effect on NDF intake or digestibility. In conclusion, S. cerevisiae CNCM I-1077 reduced the intraday variation of rumen bacteria and increased the amount of NDF digested per day. These observations could be associated with the tendency of increased ADG and feed efficiency in growing cattle fed a low-quality forage.
Improvement, identification, and target prediction for miRNAs in the porcine genome by using massive, public high-throughput sequencing data
Authors: Fu Yuhua , Fan Pengyu , Wang Lu , Shu Ziqiang , Zhu Shilin , Feng Siyuan , Li Xinyun , Qiu Xiaotian , Zhao Shuhong , Liu Xiaolei 
Published: January 2021

Abstract
Despite the broad variety of available microRNA (miRNA) research tools and methods, their application to the identification, annotation, and target prediction of miRNAs in nonmodel organisms is still limited. In this study, we collected nearly all public sRNA-seq data to improve the annotation for known miRNAs and identify novel miRNAs that have not been annotated in pigs (Sus scrofa). We newly annotated 210 mature sequences in known miRNAs and found that 43 of the known miRNA precursors were problematic due to redundant/missing annotations or incorrect sequences. We also predicted 811 novel miRNAs with high confidence, which was twice the current number of known miRNAs for pigs in miRBase. In addition, we proposed a correlation-based strategy to predict target genes for miRNAs by using a large amount of sRNA-seq and RNA-seq data. We found that the correlation-based strategy provided additional evidence of expression compared with traditional target prediction methods. The correlation-based strategy also identified the regulatory pairs that were controlled by nonbinding sites with a particular pattern, which provided abundant complementarity for studying the mechanism of miRNAs that regulate gene expression. In summary, our study improved the annotation of known miRNAs, identified a large number of novel miRNAs, and predicted target genes for all pig miRNAs by using massive public data. This large data-based strategy is also applicable for other nonmodel organisms with incomplete annotation information.
Death by suicide, other externally caused injuries and cardiovascular diseases within 6 months of cancer diagnosis (J-SUPPORT 1902)
Authors: Harashima Saki , Fujimori Maiko , Akechi Tatsuo , Matsuda Tomohiro , Saika Kumiko , Hasegawa Takaaki , Inoue Keisuke , Yoshiuchi Kazuhiro , Miyashiro Isao , Uchitomi Yosuke , J Matsuoka Yutaka 
Published: January 2021

Abstract

Objective
To conduct the first national population-based study in Japan to characterize risks of death by suicide, other externally caused injuries and cardiovascular diseases within 6 months of cancer diagnosis.

Methods
Cancer patients diagnosed between 1 January and 30 June 2016 and registered in the National Cancer Registry in Japan were followed up until death or 6 months after diagnosis. We calculated standardized mortality ratios and excess absolute risks per 10 000 person-years for death by suicide, other externally caused injuries and cardiovascular diseases compared with the Japanese general population.

Results
Of 546 148 patients with cancer (249 116 person-years at risk), we observed 145 suicides, 298 deaths due to other externally caused injuries and 2366 cardiovascular deaths during the follow-up period. Standardized mortality ratios within 6 months were 2.68 for suicide (95% confidence interval, 2.26–3.16; excess absolute risk, 3.65), 1.49 for other externally caused injuries (95% confidence interval, 1.32–1.67; excess absolute risk, 3.92) and 1.38 for cardiovascular diseases (95% confidence interval, 1.33–1.44; excess absolute risk, 26.85). Risks were highest during the first month after cancer diagnosis (standardized mortality ratios: suicide, 4.06 [95% confidence interval, 2.90–5.53]; other externally caused injuries, 2.66 [95% confidence interval, 2.17–3.12] and cardiovascular diseases, 2.34 [95% confidence interval, 2.18–2.51]).

Conclusions
The first 6 months, and especially the first month, after cancer diagnosis were found to be a critical period for risks of death by suicide, other externally caused injuries and cardiovascular diseases. Our findings suggest that oncologists need to evaluate suicidal and cardiovascular risks of patients immediately after cancer diagnosis and provide preventive interventions.
Prevalence of Underlying Medical Conditions Associated With Severe COVID-19 Illness in Adult Cancer Survivors in the United States
Authors: Jiang Changchuan , Yabroff K Robin , Deng Lei , Perimbeti Stuthi , Han Xuesong 
Published: January 2021

Abstract
Cancer, and other underlying medical conditions including chronic obstructive pulmonary disease, heart diseases, diabetes, chronic kidney disease, and obesity, are associated with increased risk of severe coronavirus disease 2019 (COVID-19) illness. We identified 6411 cancer survivors and 77 748 adults without a cancer history from the 2016-2018 National Health Interview Survey and examined the prevalence and sociodemographic factors associated with these conditions in the United States. Most survivors reported having 1 or more of the conditions (56.4%, 95% confidence interval [CI] = 54.8% to 57.9%, vs 41.6%, 95% CI = 40.9% to 42.2%, in adults without a cancer history), and nearly one-quarter (22.9%, 95% CI = 21.6% to 24.3%) reported 2 or more, representing 8.7 million and 3.5 million cancer survivors, respectively. These conditions were more prevalent in survivors of kidney, liver, and uterine cancers as well as Black survivors and those with low socioeconomic status and public insurance. Findings highlight the need to protect survivors against COVID-19 transmission in health-care facilities and to prioritize cancer patients, survivors, caregivers, and their health-care providers in vaccine allocation.
Adaptive responses to drought of twoRetama raetamsubspecies from Tunisia
Authors: Gil Ricardo , Zayoud Dhikra , Ouerghi Zeineb , Boscaiu Monica , Vicente Oscar , Neffati Mohamed 
Published: January 2021

AbstractAimsThe survival and ecological distribution of plants in arid habitats are mainly conditioned by water availability and physiological adaptations to withstand drought. In the present study, we have compared the physiological responses to drought of two Retama raetam (retama) subspecies from Tunisia, one of them living under the desert climate (subsp. raetam) and the other one growing on the coast (subsp. bovei).MethodsTo physiologically characterize the two R. raetam subspecies, and to elucidate their main mechanisms underlying their tolerance to drought stress, parameters related to seed germination, growth, photosynthesis (net photosynthetic rate, intracellular CO2 concentration, transpiration rate, stomatal conductance and water-use efficiency) and accumulation of osmolytes (proline, glycine betaine [GB] and soluble sugars) were determined in 4-month-old plants subjected to stress for up to 1 month.Important FindingsDrought significantly inhibited germination, growth and all the evaluated photosynthetic parameters. Plants of R. raetam subsp. bovei were severely affected by drought after 3 weeks of treatment when photosynthesis rates were up to 7-fold lower than in the controls. At the same time, proline and GB significantly accumulated compared with the irrigated controls, but much less than in R. raetam subsp. raetam; in the latter subspecies, proline and GB increased to levels 24- and 6-fold higher, respectively, than in the corresponding controls. In summary, the population living in the desert region exhibited stronger tolerance to drought stress than that adapted to the semiarid littoral climate, suggesting that tolerance in R. raetam is dependent on accumulation of osmolytes.
Above- and belowground trait linkages of dominant species shape responses of alpine steppe composition to precipitation changes in the Tibetan Plateau
Authors: Zheng Zhi , Zhang Yue , Zhang Shihu , Ma Qun , Gong Dajie , Zhou Guoying 
Published: January 2021

Abstract

Aims
Human activities and global changes have led to alterations in global and regional precipitation regimes. Despite extensive studies on the effects of changes in precipitation regimes on plant community composition across different types of grassland worldwide, few studies have specifically focused on the effects of precipitation changes on high-altitude alpine steppe at community and plant species levels in the Tibetan Plateau.

Methods
We investigated the effects of growing-season precipitation changes (reduced precipitation by 50%, ambient precipitation, enhanced precipitation by 50%) for 6 years on plant community composition in an alpine steppe of the Tibetan Plateau by linking above- to belowground traits of dominant species.

Important Findings
We found that reduced precipitation shifted community composition from dominance by bunchgrass (primarily Stipa purpurea) to dominance by rhizomatous grass (primarily Leymus secalinus). Roots and leaf traits of L. secalinus and S. purpurea differed in their responses to reduced precipitation. Reduced precipitation enhanced root vertical length and carbon (C) allocation to deep soil layers, and decreased the leaf width in L. secalinus, but it did not change the traits in S. purpurea. Moreover, reduced precipitation significantly enhanced rhizome biomass, length, diameter and adventitious root at the rhizome nodes in L. secalinus. These changes in traits may render rhizomatous grass greater competitive during drought stress. Therefore, our findings highlight important roles of above- and belowground traits of dominant species in plant community composition of alpine steppe under precipitation change.
Development of intravaginal rod insert bearing liposomal raloxifene hydrochloride and Leuprolide acetate as a potential carrier for uterine targeting
Authors: Patel Arpita , Dhande Rahul , Thakkar Hetal 
Published: January 2021

Abstract

Objectives
This project aimed at the formulation of dual drug entrapped liposomes held as freeze-dried intravaginal rod insert (IVR), to be administered by vaginal route for uterine targeting.

Methods
Liposomes were formulated by dehydration–rehydration method using 3 : 1 molar ratio of1,2-distearoyl-sn-glycero-3-phosphocholine : Cholesterol. Characterization was done for vesicle size, zeta potential, entrapment efficiency, surface morphology and % loading.

Key findings
Spherical and discrete vesicles of size 354 nm were observed in transmission electron microscopy (TEM) image. The entrapment efficiency of 90.91% and 74.3% w/w was obtained for Raloxifene Hydrochloride (RLX) and Leuprolide acetate (LA) respectively. Drug release was sustained for 6 days. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results showed that dual drug entrapped liposomal formulation show significant cytotoxicity, as also confirmed by higher apoptosis in cell cycle analysis and apoptosis studies (FACS) analysis. Pharmacodynamic studies in New Zealand white female rabbits revealed that intravaginal administration of RLX-LA entrapped liposomal formulation shows considerable fibroid regression.

Conclusions
Uterine targeting of liposomal RLX-LA suggests its potential to solve the limitations of the presently available therapeutic options.
Syrians in Sweden: Constructing Difference Regarding Gender and Family
Authors: Rabo Annika , Estrada Tun Paula , Jörum Emma 
Published: January 2021

Abstract
In this article, we look at the discourse used by the Swedish state in describing non-European migrants, among them Syrians, and how this has constructed cultural divisions between ‘native’ Swedes and Syrian migrants. We reveal how non-European immigrants are depicted and treated by the state as coming from ‘patriarchal’ and ‘collectivist’ cultures and are therefore in need of development. We then connect this framing of migrant culture to how honour-related violence is constructed by the state and public institutions and explain how such a framing of violence is problematic. We also look at how some Syrian migrants have in turn employed stereotypical language in their depiction of Swedish culture and the Swedish state. Engaging with existing work on ethnic groups and boundaries, we find that this boundary-making process by both migrants and the state produces a perception of difference among groups.