bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Low Relapse Rates of Schizophrenia In Southern Thailand: A University Hospital-Based Study
Authors: Pitanupong Jarurin , Ratanaapiromyakij Pran , Teetharatkul Teerapat 
Published: September 2021

Abstract
Background: Schizophrenia is a chronic disease that has residual symptoms and relapse. Relapse prevention research will provide useful knowledge for the employment of an effective caring process. This study aims to explore factors associated with relapse rates in hospital where there are comparatively low relapse rates for schizophrenia. Method: Medical records of patients who had their first schizophrenia diagnosis, in the Songklanagarind hospital’s inpatient psychiatric unit, were retrospectively reviewed for the period from January 2007 to December 2019. This yielded data outlining demographic information, profiles of schizophrenia and treatment. Descriptive statistical analysis was utilized to process all data; and factors associated to relapse were investigated using bivariate and multivariate analyses. Results: Reviewed medical records identified a sample size of 156 schizophrenias. The majority were male (50.6%), Buddhist (85.9%), unmarried (80.1%), unemployed (50.6%) and living with their families (90.4%). Their mean age was 39.2 years. Relapse was defined as readmission to a psychiatric unit within 5 years after their first psychotic episode. From the 156 patients, 53.8% featured relapse whereas 46.2% were in remission. Cumulatively, the first to the fifth-year relapse rate was 22.4%, 35.3%, 44.9%, 50.0%, and 53.8% respectively. Multivariate analysis indicated that patients having stressful life events, non-adherence to medication, prescription changes and lack of insight were all factors with a statistically significant association to relapse rates.Conclusions: Stressful life events, adverse events, medical non-adherence, change prescription, and lack of insight were related to relapse. Emphasizing multimodality of treatment could be key to successful relapse prevention for schizophrenia.
Efficient NC Process Scheme Generation Method Based on Reusable Macro and Micro Process Fusion
Authors: Huang Bo , He Kai , Huang Rui , Zhang Feifei , Li Xiuling , Zhang Shusheng 
Published: September 2021

Abstract
Process reuse technology has been widely studied and applied in manufacturing industry. However, the current NC process reuse generally assumes that the micro process is compatible with the macro process, but in fact, the reusable processes from the similar local structures of multiple parts are usually difficult to be compatible with each other under the overall manufacturing requirements of the query parts, which leads to the fact that a large amount of user interactions are still required for modification and adjustment in practical engineering applications, so it is not significant to improve the design efficiency. Therefore, an efficient NC process scheme generation method based on reusable macro and micro process fusion is proposed in this paper. Firstly, according to the calculation of semantic distance of process design intention, the micro processes are mapped to the macro process to realize the fusion of the macro process and the micro process, and a compatibility credibility evaluation model is established to evaluate the compatibility of fusion results. Then, when the fusion result is credible, the machining areas corresponding to the process scheme are adjusted and optimized from the geometric level. The adjustment and optimization of machining areas mainly realize the integration of machining areas and the optimization of machining sequence. Finally, the effectiveness and feasibility of the proposed method are verified by the test of actual parts.
Single Cell Sequencing Analysis Identifies Genetics-Modulated ORMDL3+ Cholangiocytes Having Higher Metabolic Effects On Primary Biliary Cholangitis
Authors: Xiang Bingyu , Deng Chunyu , Qiu Fei , Li Jingjing , Li Shanshan , Zhang Huifang , Lin Xiuli , Huang Yukuan , Zhou Yijun , Su Jianzhong , Lu Mingqin , Ma Yunlong 
Published: September 2021

Abstract
Background: Primary biliary cholangitis (PBC) is a classical autoimmune disease, which is highly influenced by genetic determinants. Many genome-wide association studies (GWAS) have reported that numerous genetic loci were significantly associated with PBC susceptibility. However, the effects of genetic determinants on liver cells and its immune microenvironment for PBC remain unclear. Results: We constructed a powerful computational framework to integrate GWAS summary statistics with scRNA-seq data to uncover genetics-modulated liver cell subpopulations for PBC. Based on our multi-omics integrative analysis, 29 risk genes including ORMDL3, GSNK2B, and DDAH2 were significantly associated with PBC susceptibility. By combining GWAS summary statistics with scRNA-seq data, we found that cholangiocytes exhibited a notable enrichment by PBC-related genetic association signals (Permuted P < 0.05). The risk gene of ORMDL3 showed the highest expression proportion in cholangiocytes than other liver cells (22.38%). The ORMDL3+ cholangiocytes have prominently higher metabolism activity score than ORMDL3- cholangiocytes (P = 1.383×10-15). Compared with ORMDL3- cholangiocytes, there were 77 significantly differentially expressed genes among ORMDL3+ cholangiocytes (FDR < 0.05), and these significant genes were associated with autoimmune diseases-related functional terms or pathways. The ORMDL3+ cholangiocytes exhibited relatively high communications with macrophage and monocyte. Compared with ORMDL3- cholangiocytes, the VEGF signaling pathway is specific for ORMDL3+ cholangiocytes to interact with other cell populations. Conclusions: To the best of our knowledge, this is the first study to integrate genetic information with single cell sequencing data for parsing genetics-influenced liver cells for PBC risk. We identified that ORMDL3+ cholangiocytes with higher metabolism activity play important immune-modulatory roles in the etiology of PBC.
Inhibitory Effects of Syzygium jambos Extract on Biomarkers of Endothelial Cell Activation
Authors: Inostroza-Nieves Yaritza , Valentin-Berrios Shirley , Vega Christopher , Prado Gregory N. , Luciano-Montalvo Claribel , Romero José R. , Rivera Alicia 
Published: September 2021

Abstract
Background: Disordered endothelial cell activation plays an important role in the pathophysiology of atherosclerosis, cancer, sepsis, viral infections, and inflammatory responses. There is interest in developing novel therapeutics to regulate endothelial cell function in atherothrombotic, metabolic, vascular, and hematological diseases. Extracts from leaves of the Syzygium jambos (L.) Alston (S. jambos) trees have been proposed to treat cardiovascular diseases and diabetes through unclear mechanisms. We investigated the effects of the S. jambos extract on biomarkers of endothelial dysfunction and immune responses in the human endothelial cell line, EA.hy926. Methods: Leaves of S. jambos were collected, concocted and lyophilized. To study the effects of S. jambos on endothelial cell activation, we used the human endothelial cell line. IL-6 levels were measured using qPCR and ELISA. PDI activity was measured using Insulin Turbidity and Di-E-GSSG assays. CM-H2DCFDA was used to study ROS levels. Migration assay was used to study S. jambos effect on ex vivo human polymorphonuclear and human mononuclear cells.Results: Our results show that incubation of EA.hy926 cells with ET-1 led to a 6.5 ± 1.6 fold increase in IL-6 expression by qPCR, an event that was blocked by S. jambos. Also, we observed that ET-1 increased extracellular protein disulfide isomerase (PDI) activity that was likewise dose-dependently blocked by S. jambos (IC50=14µg/mL). Consistent with these observations, ET-1 stimulated ex vivo human polymorphonuclear and mononuclear cell migration that also was dose-dependently blocked by S. jambos. In addition, ET-1 stimulation led to significant increases in ROS production that were sensitive to S. jambos. Conclusion: Our results suggest that the S. jambos extract represents a novel cardiovascular protective pharmacological approach to regulate endothelial cell activation, IL-6 expression, and immune-cell responses.
Intraoperative 3D Imaging with Cone-Beam Computed Tomography Leads to Revision of Pedicle Screws in Dorsal Instrumentation – A Retrospective Analysis.
Authors: Zimmermann Felix , Kohl Katharina , Privalov Maxim , Franke Jochen , Vetter Sven Yves 
Published: September 2021

Abstract
Background: Correct positioning of pedicle screws can be challenging. Intraoperative imaging may be helpful. The purpose of this study was to evaluate the use of intraoperative 3D imaging with a cone-beam CT. The hypotheses were that intraoperative 3D imaging (1) will lead to an intraoperative revision of pedicle screws and (2) may diminish the rate of perforated screws on postoperative imaging.Methods: 351 patients (age 60.9 ± 20.3 a (15-96); m/f 203/148) underwent dorsal instrumentation with intraoperative 3D imaging with 2215 pedicle screws at a trauma center level one. This study first evaluates the intraoperative imaging. After this, 501 screws in 73 patients (age 62.5 ± 19.7 a; m/f 47/26) of this collective were included in the study group (SG) and their postoperative computed tomography was evaluated with regard to screw position. Then 500 screws in 82 patients (age 64.8 ± 14.4 a; m/f 51/31) as control group (CG), who received the screws with conventional 2D fluoroscopy but without 3D imaging, were evaluated with regard to screw position. Results: During the placement of the 2215 pedicle screws 158 (7.0%) intraoperative revisions occurred as a result of 3D imaging. Postoperative computed tomography of the SG showed 445 (88.8%) screws without relevant perforation (type A+B), of which 410 (81.8%) could be classified as type A and 35 (7.0%) could be classified as type B. 56 (11.2%) screws in SG showed relevant perforation (type C-E). In contrast, 384 (76.8%) screws in the CG were without relevant perforation (type A+B), of which 282 (56.4%) could be classified as type A and 102 (20.4%) as type B. 116 (23.2%) screws in the CG showed relevant perforation (type C-E).Conclusion: This study shows that correct placement of pedicle screws in spine surgery with conventional 2D fluoroscopy is challenging. Misplacement of screws cannot always be prevented. Intraoperative 3D imaging with a CBCT can be helpful to detect and revise misplaced pedicle screws intraoperatively. The use of intraoperative 3D imaging will probably minimize the number of revision procedures due to perforating pedicle screws.
Cognitive Computing Integrated Methodology For Smart Decision Making And Problem-Solving
Authors: Liu Jingyuan 
Published: September 2021

Abstract
Cognitive computing is the field of intelligent computational study that imitates the brain process for computational intelligence. Decision-making is part of the cognitive process in which opportunities based on certain criteria are selected for a course of action. The choice is generally made using the intelligent assistance system that can turn human decision-making into Artificial Intelligence, system engineering, machine learning approaches. Many complicated real-world problems have been solved by the desire to replicate human intelligence into robots and progress in artificial intelligent technologies. Autonomous systems with machine cognition continuously develop by using enormous data volume and processing power. The cognitive computing system uses skill and awareness derived from knowledge and intelligent decision-making. In this paper, the cognitive computing-based human speech recognition framework (CC-HSRF) takes advantage of next-generation technologies to assist smart decision-making effectively. The proposed methods overview cognitive calculation and its historical perspectives, followed by several strategies to implement algorithms for intelligent decision-making using machine learning. Methods for effective knowledge processing are explored based on cognitive computing models such as Object-Attribute-Relation (OAR). It offers visual and cognitive analytics information, highlighting the framework of conceptual vision and its difficulties. This framework aims to increase the quality of artificial intelligent decision-making based on human perceptions, comprehensions, and actions to reduce business mistakes in the real world and ensure right, accurate, informed, and timely human decisions.
Excess S-Adenosylmethionine inhibits methylation via catabolism to adenine
Authors: Fukumoto Kazuki , Ito Kakeru , Saer Benjamin , Taylor George , Ye Shiqi , Mayu Yamano , Yuki Toriba , Hayes Andrew , Okamura Hitoshi , Fustin Jean-Michel 
Published: September 2021

Abstract
The global dietary supplement market is valued at around USD 100 billion. S-adenosylmethionine is available as a supplement to improve joints and “emotional well-being” in the US since 1999, and has been a prescription drug in Europe to treat depression and arthritis since 1975, but recent studies questioned its efficacy. In our body, S-adenosylmethionine is critical for the methylation of nucleic acids, histones and many other targets. It is believed that more S-adenosylmethionine is better since it would stimulate methylations and improve health. In many organisms, methyl metabolism is critical for biological rhythms, the extent of methylation deficiency being proportional to the magnitude of rhythm disruption. Here, using biological rhythms to assess the effects of exogenous S-adenosylmethionine, we reveal that excess S-adenosylmethionine disrupts rhythms and, rather than promoting methylation, is catabolized to adenine and methylthioadenosine, toxic methylation inhibitors. This prompts for a re-evaluation of S-adenosylmethionine’ s safety as a supplement.
SARS-CoV-2 surrogate (Phi6) environmental persistence within free-living amoebae
Authors: Dey Rafik , Dlusskaya Elena , Ashbolt Nicholas J. 
Published: September 2021

Abstract
The reported persistence of SARS-CoV-2 virions in aquatic environments highlights the need to better understand potential mechanisms that may prolong its dissemination. We evaluated the possibility that amoebae might serve as transport hosts by studying the interaction of the enveloped bacteriophage Phi6, as a potential surrogated along with one of the most common amoebae in engineered aquatic environments, Vermamoeba vermiformis. Using microscopy, imaging flow cytometry and bacteriophage cell culture, our results imply that the SARS-CoV-2 surrogate triggers amoebic mitochondria and induced apoptosis to promote viral persistence in trophozoites. Furthermore, virus-infected amoebae were still infectious after 2 months within FLA cysts. These results suggest that amoebae could contribute to the environmental persistence of SARS-CoV-2, including disinfection processes. In addition, amoebae could be a successful model system for understanding respiratory virus-eukaryotic biology at the cellular and molecular levels.
Team Building Through Team Video Games: Randomized Controlled Trial
Authors: Keith Mark J , Dean Douglas L , Gaskin James , Anderson Greg 
Published: September 2021

Background
Organizations of all types require the use of teams. Poor team member engagement costs billions of US dollars annually.

Objective
This study aimed to explain how team building can be accomplished with team video gaming based on a team cohesion model enhanced by team flow theory.

Methods
In this controlled experiment, teams were randomly assigned to a team video gaming treatment or a control treatment. Team productivity was measured during both pretreatment and posttreatment team tasks. After the pretest, teams who were involved in the team video gaming treatment competed against other teams by playing the Halo or Rock Band video game for 45 minutes. After the pretest, teams in the control treatment worked alone for 45 minutes. Then, all teams completed the posttest team activity. This same experimental protocol was conducted on 2 different team tasks.

Results
For both tasks, teams in the team video gaming treatment increased their productivity significantly more (F1=8.760, P=.004) on the posttest task than teams in the control treatment. Our flow-based theoretical model explained team performance improvement more than twice as well (R2=40.6%) than prior related research (R2=18.5%).

Conclusions
The focused immersion caused by team video gaming increased team performance while the enjoyment component of flow decreased team performance on the posttest. Both flow and team cohesion contributed to team performance, with flow contributing more than cohesion. Team video gaming did not increase team cohesion, so team video gaming effects are independent of cohesion. Team video gaming is a valid practical method for developing and improving newly formed teams.
Impact of Activity Ratio, Profitability, Liquidity, and Asset Structure on Capital Structure in Food and Beverages Companies Listed On Indonesia Stock Exchange Period 2015-2019
Authors: Martini Erni , Ramli Muhammad Adyb , Gustyana Tieka Trikartika , Nugraha Nugraha 
Published: September 2021

This study has an objective to examine the effect form activity ratio (TATO), liquidity (CR), profitability (ROA), and asset structure on capital structure (DER). Data processing uses financial reports from seventeen (17) F&B companies that listed on the Bursa Efek Indonesia (BEI) from period 2015 to 2019. A total of 425 data were used as samples using purposive sampling technique. Data panel regression used to analyze data and testing hypotheses. Results showed the simultaneous influence between the activity, liquidity, profitability, and asset structure to capital structure. Partially, activity ratio and asset structure variable do not affect capital structure. This study also proved that profitability affects capital structure in positive and significant relationship, while liquidity has a negative and significant effect to capital structure. Further findings are discussed in this study.

Keywords – activity ratio, asset structure, capital structure, liquidity, profitability
FACTORS AFFECTING ONLINE IMPULSE BUYING OF CONSUMERS IN HUE CITY
Authors: Thuong Nguyen Uyen 
Published: September 2021

Abstract: this study investigates the influence of independent variables, including scarcity, serendipity and trust on online impulse buying. Besides, the paper examines the moderation role of two variables (stimulating shopping and relaxation shopping) in the interaction effects between those independent variables on online impulse buying. Data are collected from a sample of 209 consumers in Hue city. Structural equation is used to test the hypothesized relationships. The results suggest that while serendipity is significantly positive impacts on online impulse purchasing, scarcity has a significant negative influence on that one. Trust impacts on online buying as proved in some previous studies, but it has an insignificant influence in the context of impulsively online purchasing. Furthermore, stimulating shopping moderate the interaction effect between independent variables (scarcity and serendipity) on online impulse buying. However, relaxation shopping is not significant with moderation effect. By examining different type of drivers, this paper enriches knowledge on online impulse buying and suggest some implications for online retail manager and online trading platforms to attract more consumers and encourage more unplanned consumption. Keywords: Online impulse buying, Scarcity, Serendipity, Stimulating shopping, Relaxation shopping
BIẾN SỐ NHÂN KHẨU HỌC VÀ HÀNH VI CÔNG DÂN TỔ CHỨC: NGHIÊN CỨU TRONG NGÀNH KHÁCH SẠN TẠI ĐÀ NẴNG, VIỆT NAM
Authors: Diệp Trà Lục , Long Phan Hoàn , Hằng Trần Thị 
Published: September 2021

Nghiên cứu này điều tra ảnh hưởng của các yếu tố nhân khẩu học của nhân viên bao gồm giới tính, thế hệ và tình trạng hôn nhân đối với Hành vi Công dân Tổ chức (OCB). OCB bao gồm năm thành phần chính: lòng vị tha, phẩm chất công dân, sự tận tâm, tinh thần thượng võ và phong cách lịch sự. Số liệu được thu thập từ 261 nhân viên làm việc trong ngành khách sạn tại thành phố Đà Nẵng, Việt Nam. Phương pháp bình phương nhỏ nhất (OLS) được sử dụng để điều tra ảnh hưởng của giới tính, thế hệ, tình trạng hôn nhân tới OCB. Kết quả chỉ ra rằng có sự khác biệt có ý nghĩa thống kê giữa nam và nữ trong các hành vi về phẩm chất công dân, sự tận tâm, và tinh thần thượng võ, trong khi nhóm thế hệ có ảnh hưởng đáng kể đến hành vi lòng vị tha và sự tận tâm. Thêm vào đó, mặc dù kết quả chỉ cho thấy tình trạng hôn nhân có ảnh hưởng đáng kể đến phẩm chất công dân, hiệu ứng tương tác giữa hai biến giới tính và tình trạng hôn nhân chỉ ra mối quan hệ tương tác giữa hai biến này với lòng vị tha và phẩm chất công dân. Cuối cùng, một số hàm ý quản trị cũng được thảo luận.
case for an inequalities perspective in child protection
Authors: Keddell Emily 
Published: September 2021

The year 2019 represented a watershed moment for Aotearoa New Zealand’s child welfare system, as a public spotlight was shone on systemic ethnic inequities during ongoing legislative changes aimed at centering Te Tiriti o Waitangi and whänau, hapü, and iwi considerations in policy and practice. In the midst of this dialogue, Victoria University of Wellington’s School of Government hosted the “Children, Families, and the State”– a seminar series focused on the historical, current, and future role of the state in the lives of families and children. The seminars, and the discussion it generated, was due to the calls to action from speakers across the system, including leadership at Oranga Tamariki, within the family court, non-profit providers, commissioners and advocates, and academics.
The four brief essays in this edition of Policy Quarterly capture viewpoints from several of the seminar speakers. Despite their different perspectives, common threads unite them. A greater recognition of the structural causes of the historical and current patterns of ethnic inequities in child welfare system contact, a commitment to whänau, hapü, and iwi-centred policy, practice, and partnership, the authors argue, are vital for a more just and empowering system.
In this essay, Emily Keddell reflects on how a lack of an inequalities perspective in policymaking has shaped New Zealand’s unequal child welfare system, and the ways in which this perspective can drive down the number of children who enter the system in the future.
Realising treaty-based protection in Aotearoa’s child welfare system
Authors: Achmad Claire 
Published: September 2021

The year 2019 represented a watershed moment for Aotearoa New Zealand’s child welfare system, as a public spotlight was shone on systemic ethnic inequities during ongoing legislative changes aimed at centering Te Tiriti o Waitangi and whänau, hapü, and iwi considerations in policy and practice. In the midst of this dialogue, Victoria University of Wellington’s School of Government hosted the “Children, Families, and the State”– a seminar series focused on the historical, current, and future role of the state in the lives of families and children. The seminars, and the discussion it generated, was due to the calls to action from speakers across the system, including leadership at Oranga Tamariki, within the family court, non-profit providers, commissioners and advocates, and academics.
The four brief essays in this edition of Policy Quarterly capture viewpoints from several of the seminar speakers. Despite their different perspectives, common threads unite them. A greater recognition of the structural causes of the historical and current patterns of ethnic inequities in child welfare system contact, a commitment to whänau, hapü, and iwi-centred policy, practice, and partnership, the authors argue, are vital for a more just and empowering system.
In this essay, Claire Achmad discusses how Te Tiriti o Waitangi and the United Nation Convention on the Rights of the Child can be frameworks for policy change aimed at making the child welfare system both child-centred while reducing ethnic inequities.