bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank
Authors: Li Song , Toneman Masja K. , Mangnus Judith P. M. , Strocchi Stefano , van Boekel Regina L. M. , Vissers Kris C. P. , ten Broek Richard P. G. , Coenen Marieke J. H. 
Published: December 2024

SummaryIntroductionChronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear. This study aimed to identify single‐nucleotide polymorphisms associated with developing chronic postsurgical pain after abdominal surgery, one of the most common types of surgery.MethodsA genome‐wide association study was performed on 27,603 patients from the UK Biobank who underwent abdominal surgery. The robustness of identified loci was validated by split‐half validation analysis. Functionally related top loci were selected for expression validation in clinical samples of adhesions from patients with and without pain.ResultsOne locus (rs185545327) reached genome‐wide significance for association with chronic postsurgical pain development, and 10 loci surpassed the suggestively significant threshold (p < 1 × 10‐6). In the robustness analysis, eight loci had at least nominal significance. The loci passing the suggestively significant threshold were mapped to 15 genes, of which two loci contained pain‐related genes (SRPK2, PDE4D). Although marginally approaching statistical significance in the expression validation of clinical samples, the detection rate and expression level of PDE4D were modestly higher in patients with pain compared with those in the control group.DiscussionThis study provides preliminary evidence for genetic risk factors implicated in chronic postsurgical pain following abdominal surgery, particularly the PDE4D gene, which has been associated with pain in previous studies. The findings add to evidence suggesting potential for the future development of a clinically applicable tool for personalised risk prediction, aiding clinicians in stratifying patients and enhancing clinical decision‐making through individualised risk assessments.
Optimized GVHD Prevention in HLA‐Mismatched Unrelated Allogeneic HCT Using a PTCY‐Based Approach
Authors: Pinto Filipe R. , Suárez‐Lledó María , Guardia Laia , Charry Paola , Cid Joan , Lozano Miquel , Pedraza Alexandra , de Llobet Noemi , Corrius Gerard , Moreno Cristina , Esteve Jordi , Serra Carles , Carreras Enric , Rosiñol Laura , Fernández‐Avilés Francesc , Rovira Montserrat , Martinez Carmen , Salas María Queralt 
Published: December 2024

ABSTRACTAlthough post‐transplant cyclophosphamide (PTCY)‐based prophylaxis has become a widely adopted strategy for preventing graft‐versus‐host disease (GVHD) in 9 out of 10 HLA‐mismatched unrelated donors (MMUDs), allogeneic hematopoietic cell transplants (allo‐HCTs), data on the safety and efficacy of PTCY in this setting remain limited. This single‐center study investigates the outcomes of 94 adults with hematological malignancies undergoing MMUD allo‐HCT with PTCY and tacrolimus (Tac) (PTCY‐Tac) between 2014 and 2023. The median age was 53 years, and 60.6% were male. Peripheral blood stem cells were infused in all cases. By Day +100, the cumulative incidence of Grades II–IV and Grades III and IV acute GVHD were 33.0% and 9.7%, with 2‐year incidence of moderate‐to‐severe chronic GVHD at 12.6%. By Day +30, 40.8% of patients experienced bacterial bloodstream infections, and 52.4% had cytomegalovirus (CMV) reactivation before letermovir prophylaxis. With letermovir's introduction, CMV reactivation rates dropped significantly, with only one case reported. At 3 years, overall survival was 60.8%, non‐relapse mortality was 23%, and the cumulative incidence of relapse was 24.5%. HLA Class I or II mismatches did not affect key outcomes or GVHD rates. These findings demonstrate that PTCY‐Tac offers effective GVHD prevention and favorable outcomes in MMUD allo‐HCT, supporting its application for patients without fully matched donors.
Fenfluramine treatment for Dravet syndrome: Long term real‐world analysis demonstrates safety and reduced health care burden
Authors: Boncristiano Alessandra , Balestrini Simona , Doccini Viola , Specchio Nicola , Pietrafusa Nicola , Trivisano Marina , Darra Francesca , Cossu Alberto , Battaglia Domenica , Quintiliani Michela , Gambardella M. Luigia , Parente Eliana , Monni Rita , Matricardi Sara , Marini Carla , Ragona Francesca , Granata Tiziana , Striano Pasquale , Riva Antonella , Guerrini Renzo 
Published: December 2024

AbstractObjectiveFenfluramine (FFA), stiripentol (STP), and cannabidiol (CBD) are approved add‐on therapies for seizures in Dravet syndrome (DS). We report on the long‐term safety and health care resource utilization (HCRU) of patients with DS treated with FFA under an expanded access program (EAP).MethodsA cohort of 124 patients received FFA for a median of 2.8 years (34.4 months). We compared data on safety and HCRU during FFA treatment with those from a same pre‐treatment period. Echocardiography was conducted every 6 months. Information collected included gender, age, and auxological parameters (height, weight, and body mass index [BMI]) at the start (T0) and follow‐up (T1); FFA treatment details (start, withdrawal, dosage); adverse events (AEs); and HCRU data including hospital admissions, status epilepticus (SE) episodes, and rescue medication use. We grouped patients by weight: ≤37.4 kg (n = 68, 54.8%) and ≥37.5 kg (n = 56; 45.1%), with FFA dosing adjusted accordingly. Statistical analyses included paired t test, Wilcoxon signed‐rank test, Kaplan–Meier analysis, and Bonferroni correction to adjust for multiple testing.ResultsMean age was 47 months at clinical diagnosis and 81 months at T0. The last follow‐up average FFA dose was .5 mg/kg/day, with a median of .4 mg/kg/day. FFA led to a 9.5% reduction in prior treatment load. At last follow‐up, 118 of 124 (91.5%) remained on FFA. Rescue medication use decreased significantly from 4.5 to 1, hospitalizations from 1 to 0, and SE episodes from 0–240 to 0–180 (p < .001 for all). Seizure freedom was achieved in 9 of 118 patients (7.6%). AEs occurred in 39 of 124 patients (31.5%), with no cardiac issues or deaths. There was an overall mean reduction in BMI, with no statistical significance, and never requiring FFA withdrawal.SignificanceFFA is well tolerated, without cardiac toxicity, and reduces treatment load and HCRU, suggesting improved patient management. BMI reduction in young children highlights the need for growth and nutritional monitoring.
MoS2@porous biochar derived from rape pollen as anode material for lithium‐ion batteries
Authors: Wang Yifei , Wang Chunmei , Wang Shengqiang , Zhang Huakang , Liu Zhigang , Wang Jing , Yang Lirong 
Published: December 2024

AbstractPreparation of porous carbon from natural biomass offers attractive features to facilitate the specific capacity and promote the rate capability of lithium‐ion battery (LIB). Herein, the hollow mesh porous rape pollen carbon (RPC) microsphere derived from treated RP (TRP) was utilized as a skeleton to load MoS2 nanoparticles. The MoS2@porous biochar‐derived RP (MoS2@RPC) anode materials were obtained by the hydrothermal–pyrolysis route. Attributing to the synergistic effect of spherical, hollow, and mesh porous carbon skeletons, larger specific surface areas, evenly distributed MoS2 nanoparticles, and an appropriate amount of TRP, the MoS2@RPC‐1.0 (TRP amount of 1.0 g) anode material reveals exceptional rate capability and cycling stability. A high specific capacity of ∼800 mAh g−1 at 100 mA g−1 is observed after 100 cycles, and that of ∼600 mAh g−1 at 500 mA g−1 is also obtained after 500 cycles. In conclusion, the MoS2@porous biochar composite is expected to become one of the most promising anode materials for LIBs.
Analysing the Effects of Organisational Politics on Nurses' Outcomes: The Moderating Role of Nurses' Professional Self‐Concept
Authors: Garcia‐Pereyra Facundo , Matute Jorge , Argilés‐Bosch Josep Maria 
Published: December 2024

ABSTRACTAimsTo analyse how organisational politics can affect behavioural responses such as organisational deviance and organisational citizenship behaviour towards the organisation among nurses. It also investigates the mediating effect of affective commitment between organisational politics and behavioural responses, and assesses the moderating effect of nurses' professional self‐concept in the relationship between organisational politics and its outcomes.DesignA cross‐sectional study was performed among 229 nurses.MethodsData were collected between May and November 2019. The sample demonstrates its representativeness of the nursing population based on several demographic characteristics.ResultsThe study reveals that organisational politics has a positive effect on organisational deviance and nurses' professional self‐concept has a positive moderating effect on this relationship. Affective commitment mediates the relationship between organisational politics and organisational citizenship behaviour towards the organisation.ConclusionsFrom a social exchange perspective, this research identifies the moderating role of nurses' professional self‐concept in the relationship between organisational politics and organisational deviance. Drawing on the conservation of resources theory, our study contributes to a better understanding of how the non‐significant relationship between organisational politics and organisational citizenship behaviour towards the organisation is mediated by affective commitment.Implications for the ProfessionNursing managers should pay special attention to organisational political perceptions among nurses with elevated professional self‐concepts and address them through a collaborative organisational culture and clear norms to mitigate the adverse organisational consequences of organisational politics among nurses. In this sense, managers should actively listen and communicate effectively, as they represent the organisation's values.No Patient or Public ContributionNo patient or public contribution was involved in this study.ImpactThe results of this study provided a better understanding of the organisational politics' effects among nurses on relational and behavioural responses and the moderating role of professional self‐concept in these relationships.
Multicriteria assessment of optical coherence tomography using non‐raster trajectories
Authors: Osinde Nahashon O. , Andreff Nicolas 
Published: December 2024

AbstractThis article presents a qualitative, quantitative, and experimental analysis of optical coherence tomography (OCT) volumes obtained using different families of non‐raster trajectories. We propose a multicriteria analysis to be used in the assessment of scan trajectories used in obtaining OCT volumetric point cloud data. The novel criteria includes exploitation/exploration ratio of the OCT data obtained, smoothness of the scan trajectory and fast preview of the acquired OCT data in addition to conventional criteria; time and quality (expressed as volume similarity rather than slice‐by‐slice image quality). The set of criteria proposed will be useful in assessing OCT scan trajectories for optimisation in various applications including robot assisted in vivo optical biopsy. We show in this paper that the rate of data acquisition is improved without degrading the OCT volume quality by scanning using non‐raster trajectories (they are fast, smooth, and make the galvanometer scanners have less wear and tear). In particular, the rosette scan trajectory, which was the preferred non‐raster trajectory, provided a balanced performance in having better clarity at the centre and periphery of the scanned object.
Snoring as a Possible Protective Factor for Temporomandibular Joint Disorders
Authors: Wu Yi , Xu Yan , Bi Zhijun , Chen Jintian , Song Xin , Liao Shiyu , Jin Long , Bi Zhiguo , Han Yu , Liu Jianguo 
Published: December 2024

ABSTRACTBackgroundPrevious studies have linked sleep quality to temporomandibular joint disorders (TMD), suggesting a role for snoring in this association. However, the directionality of this relationship remains a subject of debate. This investigation aimed to elucidate the connections between snoring and TMD.MethodsThis research employed a two‐sample Mendelian randomization (MR) approach, leveraging publicly available large‐scale genome‐wide association study (GWAS) data on snoring and TMD. We utilised a suite of analytical methods, including the inverse variance weighted (IVW) method, maximum likelihood estimation, adjusted profile score, weighted median, MR–Egger regression, and a series of sensitivity analyses, to rigorously assess the existence of relationships.ResultsOur findings indicate that a greater genetic predisposition to snoring is significantly associated with a reduced risk of TMD (IVW method; odds ratio [OR] = 0.156, 95% confidence interval [CI] = 0.028–0.843, p = 0.0309). Conversely, the analysis did not support a potential influence of TMD on snoring susceptibility (IVW method; 95% CI = 0.990 to 1.002, p = 0.1926). Additionally, our sensitivity analyses did not reveal any significant pleiotropy that could bias these findings.ConclusionThis MR study provides limited but novel genetic evidence supporting a potential causal link between snoring and a decreased risk of developing TMD. On the other hand, it does not substantiate an effect of TMD on the likelihood of snoring.
Region of Chief Complaint is Associated With Aesthetic Expectation in Prosthodontic Patients: A Cross‐Sectional Study
Authors: Zhu Rui , Zhang Zihan , Yan Zhebin , Yi Xiao , Zheng Yunhao , Zhan Meijun , Pei Yapeng , Xiong Xin , Yu Haiyang 
Published: December 2024

ABSTRACTObjectiveThis study aims to explore the association between aesthetic expectation and possible variables such as region of chief complaint, gender, age, chief complaint, duration and its influencing mechanism.Subjects and MethodsOne hundred and ninety‐four patients seeking prosthodontic treatment were recruited and completed the questionnaires including the Oral Health Impact Profile 5‐item (OHIP‐5), the Stigma Scale for Chronic Illness 8‐item (SSCI‐8), the Generalised Anxiety Disorder 7‐item (GAD‐7), the Psychosocial Impact of Dental Aesthetics Questionnaire 23‐item (PIDAQ‐23), aesthetic expectation and other demographic and disease‐related information.ResultsAesthetic expectation showed significant correlations with region of chief complaint (r = 0.363, p < 0.001). Multiple linear regression analysis after stratified analysis showed that aesthetic expectation was significantly positively related to social impact (1.10, 95% CI [0.30, 1.91], p = 0.009), aesthetic concern (1.29, 95% CI [0.19, 2.40], p = 0.025) and dental self‐confidence (0.94, 95% CI [0.35, 1.54], p = 0.003) while presenting a negative correlation with psychological impact (−1.24, 95% CI [−2.53, 0.05], p = 0.065) only in prosthodontic patients of aesthetic zone. Mediation analysis revealed a significant direct association between aesthetic expectation and the aesthetic zone (0.77, 95% CI [0.03, 1.53]), as well as between the aesthetic zone and the nonaesthetic zone (1.17, 95% CI [0.33, 2.00]) via PIDAQ‐23. A significant indirect association between aesthetic expectation and the aesthetic zone (0.76, 95% CI [0.41, 1.17]) as well as between the aesthetic zone and the nonaesthetic zone (1.06, 95% CI [063, 1.56]) via PIDAQ‐23 was also observed.ConclusionRegion of chief complaint is associated with aesthetic expectation via PIDAQ‐23 in prosthodontic patients. Researchers and dentists should take region of chief complaint and psychosocial impact into account when using aesthetic expectations for aesthetic analysis.
Temporomandibular Disorders in Psychiatric Outpatients: A Hidden Epidemic?
Authors: Lima Bastos Poliana , Fontenele Rodrigo , de Oliveira Debora , D'Escragnolle Taunay Tauily Claussen , Fagundes Charles , Salles Ottoboni Guilherme , Moura Batista Leonardo 
Published: December 2024

ABSTRACTBackgroundTemporomandibular disorders (TMD) are a multimodal group of orofacial pain syndromes that rank behind only chronic low back pain in the list of most prevalent musculoskeletal conditions causing pain and disability. Previous studies have recorded high rates of comorbid anxiety, depression, and poor sleep quality among TMD patients.MethodsEighty five outpatients recruited from Rhode Island Hospital's Latino and Portuguese Mental Health Programs completed the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and the Pittsburgh Sleep Quality Index questionnaire (PSQI). The latest meta‐analysis of TMD prevalence in the general population was used for the reference population (n = 3159).ResultsThe most prevalent psychiatric disorders were depressive disorders (75.3%), anxiety disorders (57.6%), and sleep–wake disorders (47.1%). Fifty patients (58.8%) met criteria for TMD, versus 29.3% in the reference population (p < 0.001). In our sample, the PSQI cut‐off for poor sleep was crossed in 96.2% of patients with TMD and 82.9% of those without TMD (p = 0.041).ObjectivesWe sought to establish the prevalence of TMD in a significant sample of psychiatric outpatients, considering their psychiatric diagnoses and sleep quality.ConclusionThe very high prevalence of TMD among patients with depression, anxiety, and sleep disorders reinforces their association and alerts us to the possibility of TMD constituting a widespread, though largely ignored, comorbidity of psychiatric outpatients that may be impacting their mental health outcomes. Further studies are needed to clarify the value of screening this population for TMD and to establish which cases merit treatment.
Investigating risk profiles of smartphone activities and psychosocial factors in adolescents during the COVID‐19 pandemic
Authors: Haag Ann‐Christin , Nick Elizabeth A. , Chen Mark S. , Telzer Eva H. , Prinstein Mitchell J. , Bonanno George A. 
Published: December 2024

AbstractAssociations of adolescents' smartphone use and well‐being have been contradictory. The present study investigates patterns of smartphone use and psychosocial risk / protective factors in US adolescents during COVID‐19 and examines their associations with depression symptom trajectories from 5 yearly waves beginning prior to the COVID‐19 pandemic. Latent profile analyses revealed three risk profiles, including a high risk profile (18.9% adolescents) characterized by elevated social media use, high levels of psychosocial risk, and low levels of protective variables. Latent growth mixture modeling identified three depression trajectories; stable low, moderate‐increasing, and high‐severely increasing depression. Both the moderate‐increasing and high‐severely increasing depression trajectories were associated with membership in the high risk profile. Results highlight the impacts of type of smartphone activity rather than use per se and can inform targeted intervention strategies.
Social support is fundamentally important for mental health among adolescents and emerging adults: Evidence across relationships and phases of the COVID‐19 pandemic
Authors: Mitchell Alicia , Johnson Chloe L. , Schroeder Emily , Ng G. Wei , Booker Jordan A. 
Published: December 2024

AbstractPeople are fundamentally driven to seek support, care, and validation from others. These are aspects of social support. Feeling sufficiently supported and cared for is important for wellness and mental health across adolescent and emerging adult development. Further, social support is valuable for wellness across both “mundane” periods of daily life as well as during times of turmoil and uncertainty. Guided by multiple frameworks on social motivation, social cognition, and ecological frameworks of development, we aimed to replicate and expand insights about social support, wellness, and mental health for adolescents and emerging adults, studying people living through periods of the COVID‐19 pandemic. We studied reports of social support, coping and distress, and mental health concerns (i.e., depression and anxiety) from middle and high school age adolescents, as well as college‐going emerging adults recruited during periods of COVID quarantine and following returns to in‐person activities in the United States. Across eight samples, social support showed positive relations with coping strategies and negative relations with depressive and anxious problems. These findings were relevant for both adolescents and emerging adults; supported across multiple time points; involved support from family, friends, and other peers; and were sustained during periods of quarantine and the return to face‐to‐face daily activities. Our work both replicates and extends insights on the essential needs of feeling supported by close others for wellness and mental health and underscores the value of investing in additional infrastructure that can foster social support across multiple relationship domains (i.e., improving family relations and building spaces for peer and friend engagement in schools).
LGBTQ+ youth policy and mental health: Indirect effects through school experiences
Authors: Moran Samantha A. , Bishop Meg D. , Watson Ryan J. , Fish Jessica N. 
Published: December 2024

AbstractThe link between state policies and LGBTQ+ youth mental health is well‐established, yet less well‐understood are the mechanisms that drive these associations. We used a sample from the LGBTQ+ National Teen Survey (n = 8368) collected in 2022 to examine whether and to what degree LGBTQ+ inclusive school strategies, student perceptions of school safety, and experiences with bias‐based bullying and peer victimization explain the association between state LGBTQ+ youth‐focused policies and LGBTQ+ youth mental health symptomology. We observed significant indirect effects between policy and LGBTQ+ youth mental health through all four constructs, suggesting that each of these more proximal school experiences was independently implicated in this association. Findings underscore how state policies shape LGBTQ+ youth mental health symptomology via more proximal contexts and emphasize the importance of policy implementation following enactment.
Age‐related changes in large muscle group movements during sleep
Authors: Mogavero Maria P. , Congiu Patrizia , Lanza Giuseppe , Ferini Strambi Luigi , Marelli Sara , Castelnuovo Alessandra , Puligheddu Monica , Bruni Oliviero , Ferri Raffaele 
Published: December 2024

SummaryThis study aims to investigate large muscle group movements (LMM) during sleep across the lifespan, from school‐aged children to older adults, and to examine their relationship with sleep architecture (REM and NREM). A total of 141 healthy participants were included, divided into five age groups: school‐aged children (n = 43), adolescents (n = 31), young adults (n = 27), adults (n = 16), and older adults (n = 24). Polysomnography (PSG) was used to record sleep data and LMM, along with LMM associated with arousals (LMMA) and awakenings (LMMW), were scored according to recently established criteria. The LMM indices and durations were analysed for each group, and statistical comparisons were made between age groups and across REM and NREM sleep. LMM indices significantly increased with age, with older adults exhibiting the highest frequency of LMM, LMMA, and LMMW. The LMM duration was longer in younger participants and shorter in older adults. Significant differences in LMM patterns between REM and NREM sleep were observed, particularly in adults and older adults, where LMM and LMMA were more prevalent in REM sleep. No significant sex differences were found across age groups. LMM during sleep showed clear age‐related trends, increasing in frequency and decreasing in duration with advancing age. These movements are more prevalent during REM sleep in older adults, reflecting age‐related sleep fragmentation and instability. The findings provide important normative data for LMM across the lifespan and demonstrate that sleep‐related motor activity is closely linked to changes in sleep architecture.