bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Investigation of the Clinical Significance and Prognostic Value of the CBXs in Esophageal Cancer
Authors: Hou Jun , Yang Yinfeng , Gao Honglei , Liu Qiwei , Ding Ran , Chen Lijun , Kan Hongxing 
Published: December 2021

Abstract
Background: Esophageal cancer (ESCA), one of the most aggressive malignant tumors, has been announced to be the ninth most common cancer and the sixth leading cause of cancer-related death in the world. Chromobox family members (CBXs) are important epigenetic regulators which are related with the transcription of target genes. The role of CBXs in carcinomas has been reported in many studies. However, the function and prognostic value of different CBXs in Esophageal cancer are still largely unknown.Methods: In this article, we first performed differential expression analysis through several methods including Oncomine and Gene Expression Profiling Interactive Analysis. The results led us to determine the differential expression of CBXs in pan-cancer, especially ESCA. Then we evaluated the prognostic value of different CBX mRNA expression in patients with ESCA through the Kaplan-Meier plotter and the Human Protein Atlas database. In addition, we used cBioPortal to explore all genetic alterations and mutations in the CBXs in ESCA. Simultaneously, the correlation between its expression and the level of immune infiltration of ESCA was visualized by TIMER. Finally, the biological function of CBXs in ESCA is obtained through Biological Enrichment Analysis including GO and KEGG.Results: The expression levels of CBX3/4/5 and CBX8 in ESCA tissues increased significantly and the expression level of CBX7 decreased through differential expression analysis. Additionally, CBX1 is significantly related to the clinical cancer stage and disease-free survival (DFS) of ESCA patients. The high mRNA expression of CBX4 is related to the short overall survival (OS) of patients with esophageal squamous cell carcinoma, and the high mRNA expression of CBX3/7/8 is related to the short OS of patients with esophageal adenocarcinoma, indicating that CBX1/3/4/7/8 may be a potential prognostic biomarker for the survival of ESCA patients. Besides, the expression of CBXs is significantly related to the infiltration of a variety of immune cells, including six types of CD4+ T cells, macrophages, neutrophils, B cells, CD8+ T cells and dendritic cells in esophageal cancer. Moreover, we found that CBXs are mainly associated with the inhibition of cell cycle and apoptosis pathway. Further, enrichment analysis indicated that CBXs and correlated genes were enriched in mismatch repair, DNA replication, cancer pathways, and spliceosomes.Conclusions: Our research may provide new insights into the choice of prognosis biomarkers of the CBXs in esophageal cancer.
Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation
Authors: Macedo Lélia Lilianna Borges de Sousa , Antunes Flavia Tasmin Techera , Alvarenga Willyane de Andrade , Batista Mara Cristina Carvalho , de Moura Mayara Storel Beserra , Farias Mariane Nunes Lima , Caminski Emanuelle Sistherenn , Dallegrave Eliane , Grivicich Ivana , de Souza Alessandra Hubner 
Published: December 2021

Abstract
Background: Curcumin has protective actions in neuropsychiatric disorders. Its mechanism of action is associated with the restoration of catecholaminergic balance, reduction of oxidative/nitrosative stress, protection against inflammation, and neuroprotection. Objective: In a first approach, the study presents an empty review of the potential effect of curcumin on cognitive performance in attention deficit hyperactivity disorder (ADHD).Methods: On a second moment, seeing the scarcity of studies and knowing that ADHD is related to hyperactive and anxious behavior, 20 spontaneously hypertensive Wistar rats (SHR) were divided into groups that received water (1 mg/kg/day), curcumin (50 mg/kg/day), or methylphenidate (1 mg/kg/day) for 42 days. Behavioral tests to assess activity (Open Field test), anxiety and impulsivity (Elevated Plus Maze, and Social Interaction), and memory (Y Maze and Object Recognition Test) were performed. Results: Animals treated with curcumin showed less anxious and hyperactive behavior. Related to the memory, the results can be related to hyperactivity. Conclusion: Thus, the data suggest that the treatments used here can beneficially modulate the anxious and hyperactive behavior of SHR.
Contralateral Eye Study On The Characteristics of Corneal Aberration In Patients With Bilateral Keratoconus And Unilateral Corneal Vogt’s Striae
Authors: Li Jing , Zhang Yaohua , Li Yong , Cai Yan , Du Jing , Liu Jianguo , Wei Shengsheng 
Published: December 2021

Abstract
Purpose: To assess the corneal high-order aberration(HOA) and its correlation with corneal morphological parameters in patients with bilateral keratoconus (KCN) and unilateral Vogt’s striae.Methods: A total of 168 eyes of 84 patients with KCN, whose corneas had definite signs of unilateral Vogt’s striae were enrolled. Corneal HOA and morphological parameters were measured using Pentacam HR.Results: The corneal morphological parameters between KCN eyes with and without Vogt’s striae were evidently different (P < 0.001). The 3rd coma 90°, 4th spherical aberration, 5th coma 90°, RMS (total), and RMS (HOA) in the front, back surfaces and total cornea in KCN eyes with Vogt’s striae were significantly higher than those in KCN eyes without Vogt’s striae (P < 0.001). In KCN eyes with Vogt’s striae, the 3rd coma 90° and 4th spherical aberration in the front surface and total cornea were negatively correlated with K1, K2, Km, Kmax, ACE, and PCE (P < 0.05). The 3rd coma 90° , 4th spherical aberration in back surface and RMS (total), RMS (HOA) in the front, back surfaces, total cornea were positively correlated with K1, K2, Km, Kmax, ACE, and PCE (P < 0.05).Conclusions: Corneal HOA especially vertical coma and spherical aberration may increase when Vogt’s striae appeared in KCN eyes. The scale of increase was significantly related with changes in corneal shapes.
Waste Treatment Innovation For Infusion Bottle Using Soil Solution
Authors: Marsum Marsum , Sunarto Sunarto , Widodo Widodo , khayan khayan , Wardoyo Slamet 
Published: December 2021

Abstract
Disposal of medical or clinical waste into the environment can cause nosocomial and other environmental pollution. Treatment of medical or clinical waste requires modern technology and very high processing costs. Medical waste treatment requires innovation in processing medical waste to be easy to apply in health care facilities. For this reason, it is necessary to innovate antibacterial methods to clean bacteria. This study used an experimental design using a completely randomized design. The treatment was carried out by rinsing with sterile distilled water seven times, using 45% soil with a contact time of 2 minutes. Experiments in the study were carried out twice. The effect of treatment on decreasing the number of bacteria used a mathematical model of Multiple Linear Regression. The results show that the disinfection of infusion bottles is contaminated with bacteria. When using water only requires rinsing up to 6 times, it is sufficient to rinse only once if using a soil solution. Disinfection of infusion bottles contaminated with bacteria using soil solution was able to reduce the number of bacteria by 98%.
Long-Term Outcome of Idiopathic and Acquired Dystonia After Pallidal Deep Brain Stimulation: A Case Series
Authors: Tai Chun-Hwei , Chou Sheng-Che , Lin Chin-Hsien , Lee Wang-Tso , Wu Ruey-Meei , Tseng Sheng-Hong 
Published: December 2021

Abstract
BACKGROUND

Among dystonia patients receiving globus pallidus internus (GPi) deep brain stimulation (DBS), long-term outcomes remain to be established.
OBJECTIVE

To report the long-term outcome of GPi DBS in a patient cohort with idiopathic and acquired dystonia.
METHODS

In this long-term follow-up cohort, there were 4 patients with idiopathic dystonia and 2 patients with acquired dystonia. The Burk-Fahn-Marsden Dystonia Rating Scale (BFMDRS) was used to evaluate 6 consecutive patients preoperatively and at 6 months, 12 months, and the last follow-up. The relationship between etiology and clinical improvement was analyzed. Stimulation parameters were evaluated for similarities and differences among these patients.
RESULTS

The mean follow-up of our cohort was 65.3 months (median 40.5 months). The average improvement in BFMDRS (mean ± SEM) was 56% ± 7.6, 67% ± 6.8 and 66% ± 9.7 at 6 months, 12 months, and last follow-up, respectively. There was greater improvement during long-term follow-up in the 4 patients with idiopathic dystonia than in the 2 patients with acquired dystonia. The 2 most ventral electrodes (contact 0 and 1) were activated in all 11 leads in this cohort. The average stimulation intensity, pulse width and frequency were 2.0 ± 0.24 mA, 252 ± 43 µs, and 99 ± 6.0 Hz, respectively.
CONCLUSION

Isolated dystonia, either monogenetic or idiopathic, usually responds better to GPi DBS than does acquired dystonia. Selection of patients by dystonia etiology, accurate placement of DBS leads in GPi targets, and proper stimulation programming are crucial to achieve better long-term outcomes.
Diospyros Kaki Leaves Decoction Phytochemical Characterization and Bioactivities Evaluation: LC-MS-Qtof Identification, Antioxidant Activity, Enzyme Inhibition and Cytotoxicity Toward HepG2 and Mcf-7 Cell Lines
Authors: Ressaissi Asma , Mannai Amna , Ben-Attia Mossadok , Serralheiro Maria Luísa , El-Bok Safia 
Published: December 2021

Abstract
Diospyros kaki known as Persimmon has played an important role in Chinese medicine, and its leaves are used in pharmaceuticals, cosmetics, and beverages due to their biological properties. The aim of this study was to evaluate chemical composition, antioxidant activity, enzyme inhibition. The main compounds of Diospyros kaki leaves decoctions were identified using high-resolution liquid chromatography – high-resolution tandem mass spectrometry (LC-HRMS-MS) interfaced with a Quadrupole Time-of-Flight (Q-tof). The obtained results showed that the aqueous extract had a high content of total phenolsand flavonoids and showed strong antioxidant activity (EC50 between 3.79±0.19 and 12.05±0.11µg/mL). In addition, these extracts were able to inhibit3-hydroxy-3-methylglutaril-CoA (HMG-CoA) reductase and acetylcholinesterase (IC50 ranging from 58.35±0.69 to 210.21±28.9 µg/mL). The cytotoxicity against human liver cells HepG2 and breast MCF7 cell lines was also evaluated. No cytotoxicity to HepG2 and MCF7 cells was detected. These results indicate that Diospyros kaki leaves could be considered as attractive source of health-promoting ingredients and a promising plant for the development of new functional foods and pharmaceutical products.
Cubesat Constellations Provide Enhanced Crop Phenology And Digital Agricultural Insights Using Daily Leaf Area Index Retrievals.
Authors: Johansen Kasper , Ziliani Matteo G. , Houborg Rasmus , Franz Trenton E. , McCabe Matthew F. 
Published: December 2021

Abstract
Satellite remote sensing has great potential to deliver on the promise of a data-driven agricultural revolution, with emerging space-based platforms providing spatiotemporal insights into precision-level attributes such as crop water use, vegetation health and condition and crop response to management practices. Using a harmonized collection of high-resolution Planet CubeSat, Sentinel-2, Landsat-8 and additional coarser resolution imagery from MODIS and VIIRS, we exploit a multi-satellite data fusion and machine learning approach to deliver a radiometrically calibrated and gap-filled time-series of daily leaf area index (LAI) at an unprecedented spatial resolution of 3 m. The insights available from such high-resolution CubeSat-based LAI data are demonstrated through tracking the growth cycle of a maize crop and identifying observable within-field spatial and temporal variations across key phenological stages. Daily LAI retrievals peaked at the tasseling stage, demonstrating their value for fertilizer and irrigation scheduling. An evaluation of satellite-based retrievals against field-measured LAI data collected from both rain-fed and irrigated fields shows high correlation and captures the spatiotemporal development of intra- and inter-field variations. Novel agricultural insights related to individual vegetative and reproductive growth stages were obtained, showcasing the capacity for new high-resolution CubeSat platforms to deliver actionable intelligence for precision agricultural and related applications.
Placebo Analgesia Changes on Self-Pain and Empathy for Pain: Influences of Event-Related EEG Oscillations, Heart Rate Variability, and Personality
Authors: De Pascalis Vilfredo , Vecchio Arianna 
Published: December 2021

Abstract
We induced placebo analgesia (PA), a phenomenon explicitly attenuating the self-pain feeling, to assess whether this resulted in reduced empathy pain when witnessing a confederate undergoing such pain experience. We recorded EEG and electrocardiogram during a painful control and PA treatment in healthy adults who rated their experienced pain and empathy for pain. We derived HRV changes and, using wavelet analysis of non-phase-locked event-related EEG oscillations, EEG spectral power differences for self-pain and other-pain conditions. First-hand PA produced a reduction of self-pain and self-unpleasantness, whereas we observed only a slight decrease of other unpleasantness. We derived linear combinations of HRV and EEG band power changes significantly associated with self-pain and empathy for pain changes using PCAs. We found that relative HR-slowing together with decreased midline ϑ-band (4-8 Hz) power directly influenced self-pain reduction and, indirectly, through chained mediating effects of the Behavioral Inhibition System and Fight-Flight-Freezing System traits. In the other-pain condition, we detected a direct influence of the midline β2-band (22-30 Hz) power reduction on the other-pain decline with a positive mediating role of Total Empathic Ability. These findings suggest that PA modulation of first-hand versus other pain relies on functionally different physiological processes involving different personality traits.
The effect of chemotherapy on the complication rates of implant and free flap breast reconstruction: A Systematic Review
Authors: Seth Ishith , Bulloch Gabriella , Gibson Damien , Seth Nimish , Hunter-Smith David J , Rozen Warren M 
Published: December 2021

Abstract
Purpose

This study investigated the impact of chemotherapy on complication rates of implant and free flap breast reconstruction. The effect of timing and dosage of chemotherapy in minimizing the breast reconstruction surgery (BRS) complications were also investigated.
Methods

PRISMA guidelines were used to search relevant studies published from January 2009 to September 2021. Quality of selected studies were assessed using GRADE assessment and risk of bias was performed using Cochrane Collaboration’s tool and ROBINS-I. Rates of major and minor complications of neoadjuvant systemic therapy (NST) and adjuvant systemic therapy (AST) were compared by t-test using GraphPad Prism v.9.3.0 and P value <0.05 was considered statistically significant.
Results

A total of 19 studies comprising 49,217 patients were included. The GRADE assessment showed low risk of bias and good quality across studies. Three-hundred and twenty patients had implant reconstruction, 3,172 had flap reconstruction and 46,062 had both flap and implant reconstruction surgery. There was no significant difference in complication rates of patients between flap reconstruction surgery and implants. (P=0.4) In all studies, total complication rates for post-chemotherapy BRS patients was 46.03% compared to 32.49% without chemotherapy (P=0.09). Overall major complications rate was 14.5% (P=0.61) with NST and 21.1% (P=0.69) with AST. Minor complications rate was 28.8% (P=0.97) with NST and 39.5% (P=0.59) with AST. Complication rate of NST was lower than AST, but not statistically significant (P=0.64). No significant correlation was found between timing/duration of chemotherapy and rates of BRS complications (P=0.76).
Conclusion

No significant difference in BRS complications with and without chemotherapy was established. Despite these results suggesting little difference between NST and AST or chemotherapy in BRS complications, prospective control studies are currently limited, and more are necessary to better inform surgeons and their patients.
Molecular Mechanism of Interaction Between Fatty Acid Delta 6 Desaturase and Acyl-CoA by Computational Prediction
Authors: Cui Jie , Chen Haiqin , Tang Xin , Zhang Hao , Chen YongQ , Chen Wei 
Published: December 2021

Abstract
Enzyme catalyzed desaturation of intracellular fatty acids plays an important role in various physiological and pathological processes related to lipids. Limited to the multiple transmembrane domains, it is difficult to obtain their three-dimensional structure of fatty acid desaturases. So how they interact with their substrates is unclear. Here, we predicted the complex of Micromonas pusilla delta 6 desaturase (MpFADS6) with the substrate linoleinyl-CoA (ALA-CoA) by trRosetta software and docking poses by Dock 6 software. The potential enzyme-substrate binding sites were anchored by analysis of the complex. Then, site-directed mutagenesis and activity verification clarified that W290, W224, and F352 were critical residues of the substrate tunnel and directly bonded to ALA-CoA. H94 and H69 were indispensable for transporting electrons with heme. H452, N445, and H358 significantly influenced the recognition and attraction of MpFADS6 to the substrate. These findings provide new insights and methods to determine the structure, mechanisms and directed transformation of membrane-bound desaturases.
Mechanical Properties of Tibetan Rubble Stone Masonry Under Uniaxial Compression
Authors: Wang Yu , Zhou Tiejun , Wang Ruheng , Wang Yuan 
Published: December 2021

Abstract
Basic mechanical properties of Tibetan rubble stone masonry, a unique architectural structure in western China, may affect the bearing capacity of architectural structures. In this study, a compression test was carried out on a Tibetan rubble prism to investigate its failure mechanism and stress-strain characteristics under uniaxial compression. Based on the experimental results, we obtained two simple compression constitutive models for Tibetan rubble stone masonry, established equations applicable to predicting the compressive strength of Tibetan rubble stone masonry, and obtained a relationship between compressive strength and the elasticity modulus through a regression analysis.
Influence of Wear Volume on Surface Quality in Grinding Process Based on Wear Prediction Model
Authors: Cao Wei , Han Zhao , Chen Ziqi , Jin Zili , Wu Jiajun , Qu Jinxiu , Wang Dong 
Published: December 2021

Abstract
In the grinding process, the workpiece would not only be cut by abrasive grains, but also have adhesive wear caused by high temperature and heavy load, which makes the surface quality of the workpiece worse. In this paper, a wear test method considering speed, force, wear coefficient, temperature and hardness was proposed. A new wear prediction physical model was established based on finite element method and numerical simulation technology. The wear test was carried out on a grinding machine. The comprehensive research on the relationship between force, temperature, surface morphology and wear volume of grinding process was studied. The relationship between workpiece speed, grinding depth, cooling lubrication conditions and wear volume of grinding process was studied. The results show that the wear model can achieve numerical prediction and trend prediction of grinding temperature, surface profile and wear volume, the relative errors between the theoretical and actual values of wear and grinding temperature are 9.84% and 2.07% respectively. This study provides a support for wear prediction and surface quality control of grinding process from the perspective of temperature and micro material removal form.
Usefulness of the modified hemophagocytic syndrome diagnostic score as a prognostic factor in lung transplantation patients
Authors: Choi Ji Yeon , Kim Song Yee , Lee Sang Hoon , Woo A La , Young Seung Hyun , Leem Ah Young , Kim Eun Young , Chung Kyung Soo , Jung Ji Ye , Kang Young Ae , Kim Young Sam , Lee Jin Gu , Paik Hyo Chae , Park Moo Suk 
Published: December 2021

Abstract
Background: Lung transplantation (LTX) is an established treatment for end-stage lung disease; however, the post-LTX mortality rate remains high. This study aimed to evaluate the prognostic value of the modified reactive hemophagocytic syndrome diagnostic score (mHScore) and its individual components on mortality after LTX.Methods: We retrospectively analyzed 294 patients who underwent LTX at Severance Hospital, Yonsei University, Korea, from January 2012 and December 2020, and classified them into high (n=114, mHScore > 104.0) and low mHScore (n=180, mHScore ≤ 104.0) groups. Triglyceride, ferritin, serum glutamic oxaloacetic transaminase, fibrinogen, and cytopenia were used to calculate the mHScore. We compared baseline characteristics and mortality rates as LTX prognostic factors.Results: The high mHScore group had significantly more cytopenia and higher ferritin, triglyceride, lactate dehydrogenase, and C-reactive protein levels than the low mHScore group. The mortality rate was significantly higher in the high than in the low mHScore group (hazard ratio, 4.429, p < 0.001). Multivariate regression analysis revealed that a high mHScore was significantly associated with postoperative mortality, even after adjusting for other confounding factors. A high mHScore was also associated with postoperative complications.Conclusions: The mHScore can be used to estimate post-LTX prognosis and predict postoperative mortality.
Depression And HIV/TB In Southern Africa: A Mixed Method Evaluation of An Integrated Primary Care Mental Health Programme In Eswatini
Authors: Putnis Nina , Riches Nick , Nyamayaro Archibald , Boucher Darah , King Rebecca , Walker Ian , Burger Alett , Southworth Paul , Mwanjali Violet , Walley John 
Published: December 2021

Abstract
Background: Depression and comorbidity with chronic illnesses is common in Southern Africa, yet there are major treatment gaps. This study evaluates the intervention ‘Healthy Activity Program’ to bridge this gap, which involves training non-specialist nurses in depression: including identification, counselling based on behavioural activation theory and structured referral. This intervention aims to be integrated into routine primary healthcare services for HIV/TB. The patient cohort were people living with HIV and/or tuberculosis (TB) (PLHIV/TB) in rural Eswatini. Aims: To assess the feasibility and acceptability of this intervention and concepts of depression in this setting.Methods: This is a pragmatic mixed methods evaluation of a pilot integrated service.Results: 324 PLHIV/TB were screened for depression, with 19% (62/324) screening positive. Attendance to counselling declined over time, with 16/62 attending the minimum 5 sessions. Qualitative results indicated acceptability, yet concerns around feasibility. Conclusions: The ‘Healthy Activity Program’ represents a promising option to manage the treatment gap for depression in PLHIV/TB. However, task-shifting onto non-specialist healthcare professionals with the aim to integrate care for these conditions in primary care, without increasing staff capacity, is a barrier to implementation. Realistic and pragmatic assessments of capacity and workforce are essential.