bluuebunny/crossref_metadata_2025_split huggingface dataset:
CST does not evict elongating telomerase but prevents initiation by ssDNA binding
Authors: Zaug Arthur J. , Lim Ci Ji , Olson Conner L. , Carilli Maria T. , Goodrich Karen J. , Wuttke Deborah S. , Cech Thomas R. 
Published: August 2021

ABSTRACTThe CST complex (CTC1-STN1-TEN1) has been shown to inhibit telomerase extension of the G-strand of telomeres and facilitate the switch to C-strand synthesis by DNA polymerase alpha-primase (pol α-primase). Recently the structure of human CST was solved by cryo-EM, allowing the design of mutant proteins defective in telomeric ssDNA binding and prompting the reexamination of CST inhibition of telomerase. The previous proposal that human CST inhibits telomerase by sequestration of the DNA primer was tested with a series of DNA-binding mutants of CST and modeled by a competitive binding simulation. The DNA-binding mutants had substantially reduced ability to inhibit telomerase, as predicted from their reduced affinity for telomeric DNA. These results provide strong support for the previous primer sequestration model. We then tested whether addition of CST to an ongoing processive telomerase reaction would terminate DNA extension. Pulse-chase telomerase reactions with addition of either wild-type CST or DNA-binding mutants showed that CST has no detectable ability to terminate ongoing telomerase extension in vitro. The same lack of inhibition was observed with or without pol α-primase bound to CST. These results suggest how the switch from telomerase extension to C-strand synthesis may occur.
Impacts of consumers’ perceived risks in eco-design packaging on food wastage behaviors
Authors: Zeng Tian 
Published: August 2021

PurposePackaging links products to consumers by delivering messages to promote healthy food consumption and reduce wastage. However, studies point to a knowledge gap and skepticism among consumers regarding the impact of eco-design packaging on food wastage reduction. To demystify this skepticism and fill the knowledge gap, this study aims to examine consumers’ perceived risks in eco-design packaging and their impact on consumer food wastage.Design/methodology/approachA survey was conducted to identify consumer-perceived risks in eco-design packaging and explain whether, and why, some dimensions of perceived risk are more influential on consumer food wastage decisions.FindingsConsumers are prevented by financial, physical, functional, temporal and social factors from adopting eco-design packaging. Through structural equation modeling, we find consumer perceived risks in eco-design packaging influence their food wastage decisions through health consciousness and environmental awareness.Practical implicationsThis study provides practical suggestions for packaging manufacturers, the food industry and policymakers.Originality/valueDrawing on the perceived risk theory, this research highlights that the impacts of consumer-perceived risks differ, depending on the dimensions considered in their food wastage decision.
A phase-oriented evaluation framework for China's PPP projects
Authors: Liu Jinchan , Guo Yubo , Martek Igor , Chen Chuan , Tian Jiawei 
Published: August 2021

PurposeThis study develops a phase-oriented evaluation mechanism based on the public–private partnership (PPP) project process and provides a preliminary framework for the promotion of the phase-oriented evaluation of PPPs in China.Design/methodology/approachThrough a literature review and survey interviews the success criteria for the implementation process of PPPs are documented. Process success criteria findings are used to populate the content of the phase-oriented evaluation. The result is then tested, revised and improved through follow-up expert interviews.FindingsThis paper identifies PPP project process success criteria. Using these criteria, a phase-oriented evaluation framework is developed. Moreover, in consultation with industry experts in the PPP field, eight evaluation aspects were determined: confirmation of project compliance and performance, confirmation of value for money, confirmation of financial affordability, trend analysis of annual performance appraisal, risk review and early warning, rebankability analysis, project externality analysis, benchmarking analysis of similar projects. These eight application aspects are analyzed in the light of the outcomes of the resulting phase-oriented evaluation framework.Research limitations/implicationsThe results of the research can only provide researchers and practitioners with generic insights regarding inputs into a phase-oriented evaluation of PPP projects. For any specific PPP project, the focus and priority of the evaluative content will vary.Practical implicationsA phase-oriented evaluation of PPP projects is put forward. This will allow project stakeholders to better track the progress of projects throughout what can be a lengthy implementation stage.Originality/valueThis study can provide governments and stakeholders with a new, theoretical understanding as to factors required of an effective phased evaluation of China's PPP projects. In that regard it will be significant value in PPP project policy and decision-making.
Exploring the antecedents of retail banks’ reputation in low-bankarization markets: brand equity, value co-creation and brand experience
Authors: Martillo Jeremías Luís Daniel , Polo Peña Ana Isabel 
Published: August 2021

PurposeThe present study aims to propose and validate a model to measure certain variables that may contribute to increasing the bankarization rate (uptake of retail banking services) among developing-economy populations characterized by poor financial literacy and low income levels.Design/methodology/approachA quantitative empirical study is carried out in the retail banking sector of a country with low-bankarization rates. Using a self-administered questionnaire distributed online, structural equation modeling is applied to analyze the relationships between value co-creation, brand experience, brand equity and reputation.FindingsThe results show that brand equity is an antecedent of reputation that values co-creation, and brand experience positively influences brand equity and that values co-creation that positively influences brand experience.Social implicationsThe bankarization rate of a developing country is generally taken as an indicator of the socioeconomic wellbeing of its population. Where there is a low-bankarization rate, this renders it more difficult for financial institutions to build their reputation to attract new customers and retain existing ones. Strategies are, therefore, proposed to improve the reputation of financial institutions in such settings and, thus, contribute to increasing the bankarization rate.Originality/valueThe findings of this study provide an original perspective that offers a deeper understanding of the mechanisms that enable banks operating in low-bankarization markets to enhance their reputation through strategies based on customer–company interaction and branding (with the variables of brand equity, brand experience and value co-creation).
How female entrepreneurs build strong business relationships: the power of gender stereotypes
Authors: Constantinidis Christina 
Published: August 2021

PurposeAdopting a feminist constructionist perspective, this article proposes an analysis of the micro-level processes and dynamics of interpersonal, gendered, business relationships between female entrepreneurs, therefore constituting an extension to network theory in the women's entrepreneurship research field.Design/methodology/approachThe qualitative research builds on a single, longitudinal case study of a successful, 15-years long collaboration between two female entrepreneurs. Qualitative data were collected over two years, through formal and informal interviews with the entrepreneurs, observations and complementary documentation. The data analysis is based on a grounded theory and narrative approach.FindingsThe article proposes a thick narrative of the evolution of the dyadic business relationship, and reveals the power of gender role stereotypes in its progressive formation and development.Research limitations/implicationsThe article produces situated knowledge about female entrepreneurs and strong interpersonal business ties. The limitations relate to the specificity of the case analysed, representing the viewpoint of privileged, white, Western, educated and wealthy female entrepreneurs. It therefore does not account for the diversity of women's entrepreneurship.Originality/valueThe article enriches and extends social network theory in the women's entrepreneurship field through analysing how gender is done in discursive and social practices at the interpersonal level. The case also constitutes an illustration of social feminism in women's entrepreneurial practice, challenging dominant gender stereotypes.
Regional government R&D investment and innovation performance: the moderating effect of geographical and organizational proximities
Authors: Zhu Dongyun , Xu Bingfen 
Published: August 2021

Purpose
This study aims to measure the moderating effect of geographical and organizational proximity by focusing on readily available Chinese regional economic data over a five-year period.

Design/methodology/approach
The authors used multilevel regression analysis to analyze the relationship.

Findings
Results show that increasing government investment in research and development (R&D) can improve innovation performance during this period, organizational proximity and geographic proximity have a positive moderate effect on the relationship between R&D investment and Innovation performance.

Originality/value
This study enriches the existing theories on government innovation input and output from the perspective of regional differences and provides meaningful guidance for current Chinese regional innovation policies.
Technological innovation management: understanding difficulties in an emerging country to enhance manufacturers performance
Authors: Matos Lucas M. , Rampasso Izabela Simon , Quelhas Osvaldo L.G. , Leal Filho Walter , Anholon Rosley 
Published: August 2021

PurposeThis study aims to discuss the difficulties faced by two large Brazilian industrial companies in technological innovation management.Design/methodology/approachInitially, a literature review is carried out using meta-synthesis technique to consolidate an expanded and detailed framework that complemented and dialoged with the difficulties presented by Oslo Manual. The difficulties presented in this framework were used as an instrument to conduct two case studies.FindingsThere were several findings, especially the adherence to the structured framework and the identification of short-term management and inflexibility of the regulatory environment as relevant difficulties for both companies.Originality/valueThe understanding of these difficulties can contribute to optimizing manufacturers performance in innovation processes. Although only two companies were analyzed, their magnitude and relevance in the sectors they belong to should be highlighted. The information presented here can greatly contribute to expanding the debates about the management of innovation by companies in emerging countries.
Measure human capital because people really matter: development and validation of human capital scale (HuCapS)
Authors: Dahiya Rinki , Raghuvanshi Juhi 
Published: August 2021

PurposeNotwithstanding the findings of several published articles on human capital, there is scarcity of a comprehensive instrument to measure it. In this direction, the objective of present research is to develop a valid and reliable scale to assess human capital.Design/methodology/approachThis research was divided into two parts. Study 1 focused on literature review of human capital measures, development of items and exploring the factor structure of human capital construct on a sample of 184 employees. Study 2 was based on the survey of 212 employees, and reliability assessment and confirmatory factor analysis was performed to validate the factor structure of human capital construct.FindingsThe findings can be summarized in two ways. Study 1 present that human capital scale is multidimensional consisting of employee capability, leadership and motivation, employee satisfaction and creativity. The findings of study 2 confirms the validity and reliability of three factor structure of human capital construct consisting of 18 items in total.Practical implicationsThe study provides a multidimensional psychometric instrument which can help in measuring the human capital of the organization from the perspective of capabilities, satisfaction and creativity and leadership and motivation. Moreover, it can serve as an aid to human resource (HR) and human resource development (HRD) professionals for human capital assessment in the organizations.Originality/valueThis study provides a measure to assess human capital in Indian manufacturing sector organizations that makes a novel contribution to the area.
Climate literacy among undergraduate students who study science in Los Angeles
Authors: Klapp Jamie , Bouvier-Brown Nicole C. 
Published: August 2021

Purpose
This study aims to analyze undergraduate science majors’ perceptions of climate change.

Design/methodology/approach
Three science major student cohorts at Loyola Marymount University – first-year exposure (first-years taking a course related to climate science), first-year control (first-years taking a course unrelated to climate science) and non-first-year exposure (non-first-years interested in climate science taking a related course) – were given a climate literacy survey at the beginning and end of each course. Student perceptions were also compared with national and local data.

Findings
First-year students exposed to the topic showed increased awareness of climate change, trust in climate scientists and acknowledgment of the scientific consensus. Exposure also increased the non-first-year cohort’s awareness that global warming is already affecting the country. All three cohorts showed greater awareness of humanity’s role in causing climate change than the public. However, misconceptions regarding technical concepts persisted throughout.

Research limitations/implications
This was a single-institution study in Los Angeles with a limited sample. Exposure to specific topics varied between cohorts, depending on the learning outcomes of each course.

Originality/value
Undergraduate science majors have a greater understanding of climate change’s anthropogenic nature compared with local and national populations. First-year students have a lower initial understanding of climate change and less trust in climate scientists than non-first-year students interested in the topic. All science majors can improve their understanding of general concepts and strengthen their confidence in scientists by taking a relevant course. Students struggle to learn specific technical concepts, but can improve their short-term comprehension through studying.
Religiosity, employee empowerment and employee engagement: an empirical analysis
Authors: Nwachukwu Chijioke , Chládková Helena , Agboga Richard Selase , Vu Hieu Minh 
Published: August 2021

PurposeThe purpose of this study was to enhance our understanding of the connection between religiosity, employee empowerment and employee engagement.Design/methodology/approachDrawing on the social exchange theory, a framework of hypotheses is developed that focusses on religiosity, employee empowerment and their impact on employee engagement. This research employed a quantitative survey and data obtained from 232 adults working in companies in Accra Ghana.FindingsThe results suggest that religiosity dimensions (extrinsic and intrinsic) have a counterbalancing effect on employee engagement dimensions (intellectual and affective). Employee empowerment predicts both intellectual and affective engagement.Research limitations/implicationsThis study has some limitations which provide opportunities for more research. First, the study is cross-sectional and focusses on employees in selected companies in Accra Ghana. More so, the participants were a convenience, majorly men (only 28% were women). This limits the generalisability of the findings and our confidence in ascertaining the “cause” and “effect” in the relationship. The present paper used a quantitative research approach; mixed method may provide in-depth insight into the subject. The study examined the direct relationship between religiosity, employee empowerment and employee engagement. Future research should explore how the effect of religiosity and employee empowerment on a relevant outcome changes according to other organisational characteristics.Practical implicationsOrganisations must develop more interest in religion's relevance and its impact on their employees' engagement. This should be done by providing the necessary platforms for employees to practice their religion. There is the likelihood of lack of engagement when an organisation fails to consider employee religious orientation or attempts to unduly regulate employees' religiosity. Empowering work environment can promote a higher level of employee engagement. It is obvious that empowered employees are focussed, energetic, enthusiastic and have positive disposition to work. These positive attitudes lead to a higher level of engagement which fosters productivity and overall organisational performance.Originality/valueThis study could contribute to the literature on religiosity, employee empowerment and employee engagement in the Ghanaian context. Therefore, there is a need to keep employees engaged and enhance productivity. This study underpins the importance of religiosity and employee empowerment in fostering employee engagement and productivity in the Ghana work setting.
A sequential route of data and document qualities, satisfaction and motivations on researchers' data reuse intentions
Authors: Kim Youngseek 
Published: August 2021

PurposeThis study examined how the qualities of both data and documents of existing datasets can contribute to researchers' satisfaction of data reuse, and how it affects their data reuse intentions mediated by attitudinal and normative beliefs of data reuse.Design/methodology/approachA combined theoretical framework integrating IS (Information Systems) Success Model and the Theory of Planned Behavior (TPB) was utilized to develop the research model of researchers' data reuse, which was evaluated using structural equation modeling based on 820 survey responses from STEM disciplines in the US.FindingsThis study found that both data and document qualities significantly contribute to researchers' satisfaction of data reuse. Then, their satisfaction significantly increases perceived usefulness and subjective norm of data reuse, and it decreases perceived risk associated with data reuse. Finally, both perceived usefulness and subjective norm significantly increases their data reuse intentions.Research limitations/implicationsThe combined theoretical framework integrating IS success model and TPB provides a new theoretical lens in understanding researchers' data reuse behaviors affected by the qualities of both data and documents.Practical implicationsThe findings of this study provided several practical implications in promoting and facilitating researchers' data reuse behaviors by improving data and document qualities of existing datasets.Originality/valueThis is one of the initial studies focusing on the roles of data and document qualities in researchers' data reuse, and it provides a systematic view of how data and document qualities influence researchers' data reuse mediated by their satisfaction of data reuse and attitudinal and normative beliefs.
Wikipedia: an unexplored resource for understanding consumer health information behaviour in library and information science scholarship
Authors: Smith Denise A. 
Published: August 2021

PurposeTo date, health information behaviour (HIB) models have not been applied to an exploration of Wikipedia as a consumer health information resource. Wikipedia has been situated and is well established as a valuable resource for the general layperson wishing to learn more about their health or the health of a loved one. This paper aims to identify an approach to exploring the role of Wikipedia in consumer health information behaviour (CHIB) that is grounded in a conceptual framework from the library and information science (LIS) discipline.Design/methodology/approachThe author draws on current HIB models and relevant theories from existing LIS literature and applies them to propose a new definition of CHIB. The author uses this definition to frame Wikipedia as an unexplored consumer health information resource in the LIS scholarship and suggests future directions for placing such investigations within a conceptual framework from LIS.FindingsThe paper finds that Longo's expanded conceptual model of health information-seeking behaviour (ECMHISB) could be valuable and useful for the exploration of CHIB in relation to Wikipedia's health and medical content. Due to Wikipedia's online nature, research framed by these models must acknowledge and take under consideration the digital divide phenomenon and various factors that influence an individual's place within it.Research limitations/implicationsThis work builds a foundation upon which future research into the role of Wikipedia's health and medical content in CHIB can be grounded. Using Longo's model, future research might provide insight into who Wikipedia is helping and who it has left behind. LIS scholars, practicing health librarians and perhaps health workers stand to gain a deeper understanding of the potential influence of Wikipedia's health information on its consumers.Originality/valueFor LIS scholars, this paper is novel in the fact that a HIB model has not yet been applied to the study of Wikipedia's health content. This paper provides a foundation for this research.
Designing a collection of two IoT-Systems for real time health telemonitoring
Authors: Mahmood Ahlam Fadhil , Rafaa Marwa Mohamad 
Published: August 2021

Purpose
This paper aims to electronic caring the health of many kinds of patients.

Design/methodology/approach
The paper opted for designing IoT health-care system bracelet used photon as controller collect with five sensors. And second using raspberry 3 B+ collect with ECG, ECG and camera. Thinkspeak cloud was used for plotting data and communicate with doctor by bylnk mobile application.

Findings
The paper provides a real data for six-Covid-19 patient in 22 days.

Originality/value
Design an IoT system that send daily information to doctor if a patient needs to visit him/her or monthly reported to the hospital. Send patient’s vital signs to doctor as curves for fast noting any problems. The proposed system can be operate on two states (special, if need to periodically monitor or normal only when any trouble occurs), It was covered the two Covid-19 patient cases simple and critical by real testing these two systems on six Covid-19 patients. The two collections were succeeded in monitoring simple and critical Covid-19 cases.