bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats
Authors: Robac Amandine , Neveu Pauline , Hugede Alizée , Garrido Elisabeth , Nicol Lionel , Delarue Quentin , Guérout Nicolas 
Published: October 2021

Abstract
Spinal cord injury (SCI) is an incurable condition in which the brain is disconnected partially or completely from the periphery. Mainly SCI are traumatic and are due to traffic, domestic or sport accidents. To date SCI are incurable and let, most of the time, the patients with a permanent loss of sensitive and motor functions. Therefore, since several decades researchers tried to develop treatments to cure SCI. Among them, recently, our lab have demonstrated that in mice, repetitive trans-spinal magnetic stimulation (rTSMS) can, after SCI, modulate the lesion scar and can induce functional locomotor recovery non-invasively. These results are promising, however before to translate them to Humans it is important to reproduce them in a more clinically relevant model. Indeed, SCI do not lead to the same cellular events in mice and Humans. In particular, SCI in Humans induce the formation of cystic cavities. That is why we propose here to validate the effects of rTSMS in rat, animal model in which SCI lead to the formation of cystic cavities, after penetrating and contusive SCI. To do so, several techniques including immunohistochemical, behavioral and MRI have been performed. Our results demonstrate that rTSMS, in both SCI models, modulates the lesion scar by decreasing the formation of cystic cavities and by improving axonal survival. Moreover, rTSMS, in both models, enhances functional locomotor recovery. Altogether, our study describes that rTSMS exerts positive effects after SCI in rats. This study is a further step towards the use of this treatment in Humans.
The Movement Process of Typical Slope Debris Flow: A Case Study of Wujia Gully, Zengda, Sichuan Province China
Authors: Yao Shunyu , Ahmed Bazai Nazir , Jiang Hu , Yi Shujian , Zou Qiang , Ahmed Tashfain , Guo Jian 
Published: October 2021

Abstract
A debris flow occurred on July 25, 2020, at Wujia gully, Sichuan Province, China. The previous debris flow in Wujia gully happened 70 years ago. The debris flow had a severe impact downstream. The primary goal of this study is to comprehend the impact of debris flow topography on the movement process. This study compiles field data evidence from locals and conducts field sampling to get specific information using Unmanned Aerial Vehicle (UAV) aerial photography. The rheological properties of debris flow slurry are obtained through soil mechanics and rheological experiments. The movement process of the debris flow was simulated using the depth-integrated continuum approach. Based on numerical simulation analysis, the influence of Wujia gully topography on the debris flow movement process was examined. The analysis reveals that the debris flow in Wujia gully is a typical viscous debris flow, and the debris flow slurry matches the properties of Bingham fluid. Based on slope and elevation, the topography of the Wujia gully debris flow path may be classified into three sections: slope movement area, channel movement area, and deposition area. Furthermore, the topography is the most important element in debris flow movement. The consistent change in the velocity of debris flows on the topographical variation was observed, combined with the viscous debris flow and resistance characteristics. This study may serve as a reference for future debris flow kinematics research and a flow channel for researching typical slope debris flow and its movement process.
Oblique-ilioischial Plate Technique: A Novel Method for Acetabular Fractures Involving Low Level Posterior Column
Authors: Chen Zhong , Wu Zhaoxiang , Chen Ge , Ou Yi , Wen Hongjie 
Published: October 2021

Abstract
Background: Complex acetabular fractures involving the anterior and posterior columns are an intractable clinical challenge. The study investigated the safety and efficacy of oblique-ilioischial plate technique for acetabular fractures involving low level posterior column. Methods: A retrospective analysis of 18 patients operated with the oblique-ilioischial plate technique by the modified Stoppa approach (or combined with iliac fossa approach) between August 2016 and July 2021 for low level posterior column acetabular fractures was conducted. The anterior column was fixed with a reconstructed plate from the iliac wing along the iliopectineal line to the pubis. The low level posterior column was fixed with the novel oblique-ilioischial plate running from the ilium to the ischial ramus. Operative time, intraoperative blood loss, reduction quality, and postoperative hip function were recorded.Results: Out of the 18 patients, 10 were male and 8 were female (mean age: 48.6±10.2 years, range: 45–62 years; mean interval from injury to operation: 7.2±1.4 days, range: 5–19 days; mean operative time: 2.1±0.3 h, range: 1. 0–3.2 hours; mean intraoperative blood loss: 300±58.4 mL, range: 200–500 mL). Postoperative reduction (Matta’s criteria) was deemed as excellent (n = 9), good (n = 4), and fair (n = 5). At the final follow-up, the hip function (modified Merle d’Aubigne-Postel scale) was deemed as excellent (n = 11), good (n = 3), and fair (n = 4). The mean union time was 4.5±1.8 months (range: 3–6 months). No implant failure, infection, heterotopic ossification, or neurovascular injury were reported. Conclusion: The oblique-ilioischial plate technique via anterior approach for acetabular fractures involving low level posterior column offers reliable fixation, limited invasion, little intraoperative bleeding, and fewer complications. However, larger multicenter control studies are warranted.
Cationic Lipid-Based Formulations for Encapsulation and Delivery of Anti-EFG1 2’OMethylRNA Oligomer
Authors: Araújo Daniela , Gaspar Ricardo , Mil-Homens Dalila , Henrqiques Mariana , Silva Bruno , Silva Sónia 
Published: October 2021

Abstract
Background: The effective protection and delivery of antisense oligomers to its site of action is a challenge without an optimal strategy. Some of the most promising approaches encompass the complexation of nucleic acids, which are anionic, with liposomes of fixed or ionizable cationic charge. Thus, the main purpose of this work was to study the complexation of cationic liposomes with anti-EFG1 2’OMe oligomers and evaluate the complex efficacy to control Candida albicans filamentation in vitro and in vivo using a Galleria mellonella model. Results: To accomplish this, cationic 1,2-dioleoyl-3-trimethylammoniumpropane (DOTAP) was mixed with three different neutral lipids dioleoylphosphocholine (DOPC), dioleoylphosphatidylethanolamine (DOPE) and monoolein (MO) and used as delivery vectors. Fluorescence Cross Correlation Spectroscopy measurements revealed a high association between antisense oligomers (ASO) and cationic liposomes confirming the formation of lipoplexes. In vitro, all cationic liposome-ASO complexes were able to release the anti-EFG1 2’OMe oligomers and consequently inhibit C. albicans filamentation up to 60 % after 72 h. In vivo, from all formulations the DOTAP/DOPC 80/20 ρchg=3 formulation proved to be the most effective, enhancing the G. mellonella survival by 40% within 48 h and by 25% after 72 h of infection.Conclusions: In this sense, our findings show that DOTAP-based lipoplexes are very good candidates for nano-carriers of anti-EFG1 2’OMe oligomers.
Effect of Various Process Parameters of EDC on Mild Steel Substrate and their Properties
Authors: PATEL RAKESH KUMAR , Pradhan Mohan Kumar 
Published: October 2021

Abstract
In the present study, A layer of the modified composite coated surface is made using Copper, molybdenum disulfide, and hexagonal boron nitride. For this process, Electrical discharge machine (EDM) is used but in reverse polarity. Various factors of the machine influenced the thickness of the deposited layer like the amplitude of peak current, duty factor, powder mixing ratio, used etc. For the deposition process, green compacted electrodes which was made after mixing the powder material in mortar for approximately 2.5 hour and post processing in Hot mount press moulding machine. After that the mixture powder was put in the Hot mounting press machine to made green compact electrode with specific parameters. Experiment was performed on EDM and many analysis were carried out to study the morphology of the coated surface. To get the morphology of the coated layer, FESEM images were examined and found the satisfying uniform distribution of deposited layer constituents with material powder mixing ratio of (Cu/HBN/MoS2) at (20/40/40) got with 50% duty factor and 10 Ampere peak current amplitude. Also done XRD, for the evidence of Cu, MoS2 and HBN.
Land Tenure Systems and Agricultural Productivity in Nigeria: a Case of Rice Production
Authors: SANUSI Saheed Olakunle , Madaki Musa Janga , David Hyelni Seth , Adole Sharon Ocheinehi 
Published: October 2021

Abstract
This study examined land tenure systems and rice productivity in Nigeria. Primary data were used for the study. Data were collected with the aid of a well-structured questionnaire. A four-stage sampling technique was used to select a total sample size of three hundred and forty-nine (349) rice farmers based on the number of questionnaires correctly filled and returned from the selected sampled size. Data were analyzed using descriptive statistics, total factor productivity, and Stochastic production frontier model. The study revealed that large portion of the land (over 94%) used for rice production were acquired through inheritance mode of land acquisition and communal type of land tenure system widely practiced. The result of total factor productivity indicated that 62.18% of the rice farmers were at sub-optimal productivity level. The results of the stochastic production frontier function revealed that seed (P< 0.10), and fertilizer application (P<0.01) were the significant factors influencing technical efficiency of rice production in the study area. Based on the findings, the study recommend that current land use act and policy should be amended to prevent concurrent grabbing of agricultural land for non-agricultural purposes in order to enhance availability and accessibility of land for agriculture.
Context-Dependent Effects of Inflammation On Retina Regeneration
Authors: Zhou Cuiping , Zhang Xiaoli , Chen Yuxi , Lin Zihao , Zhang Shuqiang , Zhang Zhiqiang , Cao Lining , Guan Huaijin , Lu Jianfeng , Xu Hui 
Published: October 2021

Abstract
Inflammation is required for the proliferation of Müller glia (MG) into multipotent progenitors (MGPCs) in the injured fish and avian retinas. However, its function in retina regeneration has not been fully understood. Here we investigated the role of inflammation in three different retinal regeneration paradigms in zebrafish (stab-injury, NMDA-injury and insulin treatment). We first show that different types of immune cells and levels of inflammatory cytokines were found in the retinas of these paradigms. Though zymosan injection alone was insufficient to induce MG proliferation in the uninjured retina, immune suppression significantly inhibited MGPC formation in all three paradigms. Enhancing inflammation promoted MGPC formation after stab-injury, while exhibiting a context-dependent role in the NMDA or insulin models. Furthermore, proper levels of inflammation promoted MG reprogramming and cell cycle re-entry after stab- or NMDA-injury, but excessive inflammation also suppressed MG proliferation in the latter model. Finally, while inflammation promoted retinal neuron regeneration after stab-injury, immune suppression surprisingly achieved the best regeneration in the NMDA model. Our study reveals the complex and context-dependent role of inflammation during retinal repair in fish, and suggests accurate inflammation management may be crucial for successful retina regeneration in mammals.
Multivariate Outlier Detection in Precipitation Series by Using Two-Dimensional Correlation
Authors: Yaşar Mutlu , Dikbaş Fatih 
Published: October 2021

Abstract
The accuracy of descriptive statistics might be influenced by the existence of outliers in data sets. An observation which might not be considered as an outlier in the univariate case might be a multivariate outlier. Therefore, determination of outliers might make multivariate analysis more robust by providing an opportunity for making required corrections before modelling studies. This paper presents the implementation of the two-dimensional correlation method in the determination of multivariate outliers among the observations of six precipitation stations in Turkey. The two-dimensional correlation method considers the averages of the parts of the whole series instead of the average of the whole series and enables determination of the location of the outlier in the compared series. The obtained results point out that an outlier analysis for hydrologic variables should consider the two-directional behavior and the presented two-dimensional correlation method proves to be a strong alternative to be used in outlier and irregularity detection studies even with a limited number of available data. The 2DCorr software used in the study is freely provided as a supplementary material.
Traditional Acupuncture and Laser Acupuncture in Chronic Nonspecific Neck Pain: Study Protocol for a Randomized Controlled Trial
Authors: PERON RAFAELA , Rampazo Érika Patrícia , Liebano Richard Eloin 
Published: October 2021

Abstract
Background: Nonspecific neck pain is a multifactorial and very common condition in adult individuals. No reports were found in the literature comparing the effectiveness of Traditional Acupuncture (TA) and Laser Acupuncture (LA) in cases of chronic nonspecific neck pain. Therefore, the aim of the present study is to investigate the effectiveness of TA and LA therapies in individuals with chronic nonspecific neck pain.Methods/design: This study will be a controlled and randomized clinical trial. A total of 60 individuals will be randomized into two groups (30 each). The TA group will receive the acupuncture treatment using needles, while the LA group will receive the laser acupuncture treatment. The acupuncture points (Tianzhu, Fengchi, Jianjing, and Jianzhongshu) will be stimulated bilaterally with needles or laser. The primary outcome will be pain intensity, determined using the numerical rating scale. The secondary outcomes will be pressure pain threshold, temporal summation of pain, conditioned pain modulation, use of analgesic drugs after treatment, and the global perceived effect scale. The assessments will be performed immediately before and after treatment. At the follow-up, 1 months after the end of the treatments, evaluation will be made of the pain intensity and the global perceived effect. Statistical analysis of the data obtained will consider a significance level of p < 0.05.Discussion: This study will provide evidence concerning the effects of LA treatment, in comparison to TA, leading to benefits for individuals suffering from chronic nonspecific neck pain.Trial registration: RBR-7vbw5gd (Brazilian Registry of Clinical Trials - ​ReBEC)
Evaluating Eye Health Care Services Progress Towards VISION 2020 Goals in Gurage Zone, Ethiopia.
Authors: Soboka Jibat Gemida , Teshome Tiliksew , Salamanca Omar , Calise Alana 
Published: October 2021

Abstract
Background Ethiopia signed the VISION 2020 Global Declaration and launched its eye health program in 2002. Since then, there has been limited systematic and comprehensive evaluation of the progress towards VISION 2020 goals in Ethiopia.Purpose To evaluate Gurage Zone progress towards VISION 2020 targets and process indicators.Method An institutional-based cross-sectional study was conducted among all public and private eye health care facilities in the Gurage Zone within the Southern Nations, Nationalities, and People Region of Ethiopia. The evaluation protocol was adopted from the VISION 2020 situational analysis data collection tool. We used this structure to evaluate progress in terms of human resources, infrastructure, and service delivery at the Zonal Health Office and facility level.Result At the time of the study, the Gurage Zone had a 1.7 million catchment area population. There was a total of five eye care centers, of which one was established by a Non-Governmental Organization. Three of these facilities were secondary eye care centers with an operating theater and two of them were primary eye care centers. At the zonal level, there is no survey data available on the prevalence of blindness. There was no systemic evaluation of VISION 2020 process indicators. The budget allocation specific to eye health care was less than 0.7% of the total budget of the office. The human resources for eye health in the catchment area were: one ophthalmologist, two cataract surgeons, five optometrists, and 12 ophthalmic nurses, which is below the VISION 2020 targets for human resources for eye health. In terms of equipment, neither primary eye care center had a slit lamp biomicroscope, and two of the three secondary eye care centers did not have intraocular pressure (IOP) measuring equipment. Only one secondary eye care center was providing glaucoma surgical services, and no center provided either emergency or elective pediatric surgery. The cataract surgical rate (CSR) determined by the study was 1967.ConclusionGurage Zone had not achieved VISION 2020 goals in terms of critical human resources and service delivery. We recommend that the Zonal Health Office carries out a focused and baseline evaluation of eye health care service achievements.
The Short-Term Efficacy of Tenofovir Alafenamide (TAF) in Acute-On-Chronic Liver Failure: A Single Center Experience
Authors: Li Zhiqin , Liu Yang , Dong Jianxia , Yan Jingya , Hu Yushu , Wang Meng 
Published: October 2021

Abstract
Background and aims: Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) reduce hepatic events and death in patients with acute-on-chronic liver failure (ACLF), but the efficacy of Tenofovir alafenamide (TAF) is less well studied. We aimed to assess the effectiveness of TAF in hepatitis B virus (HBV) related ACLF.Methods: We analyzed 106 patients with HBV-ACLF received TAF (25mg/d), ETV(0.5mg/d) for 12 weeks. The primary endpoints were overall mortality and liver transplantation (LT) at week 12. Other determined factors of biochemical response, virologic response, mortality rate, and drug safety and side-effect were also evaluated.Results: At 4 weeks and 12 weeks, patients received TAF got significantly higher HBV-DNA reduction (P<0.001), higher rate of HBV-DNA undetectbility (P<0.001), lower HBV-DNA level (P<0.001). Lower CTP scores (P=0.003) at 4 weeks in TAF group, but CTP scores showed no difference in two groups at 12 weeks (P=1.143). Lower ALT levels in TAF group at week 4 and week 12 (P=0.023, P<0.0001). The mortality rate was lower in TAF group after 4 weeks treatment(P=0.038), but two group got similar mortality rate at week 8 and week 12. As for reason cause death in HBV-ACLF patients, we found that two group patients developed similar rates of liver-related complications (P>0.05).Conclusions: The antiviral efficacy of TAF was superior than ETV for the treatment of HBV-related ACLF. TAF therapy reduced 4-week mortality rate in patients with HBV-related ACLF.
A rough set theory and deep learning based predictive system for gender recognition using audio speech
Authors: Yasmin Ghazaala , DAS ASIT KUMAR , Nayak Janmenjoy , Vimal S , Dutta Soumi 
Published: October 2021

Abstract
Speech is one of the most delicate medium through which gender of the speakers can easily be identified. Though the related research has shown very good progress in machine learning but recently, deep learning has imparted a very good research area to explore the deficiency of gender discrimination using traditional machine learning techniques. In deep learning techniques, the speech features are automatically generated by the reinforcement learning from the raw data which have more discriminating power than the human generated features. But in some practical situations like gender recognition, it is observed that combination of both types of features sometimes provides comparatively better performance. In the proposed work, we have initially extracted and selected some informative and precise acoustic features relevant to gender recognition using entropy based information theory and Rough Set Theory (RST). Next, the audio speech signals are directly fed into the deep neural network model consists of Convolution Neural Network (CNN) and Gated Recurrent Unit network (GRUN) for extracting features useful for gender recognition. The RST selects precise and informative features, CNN extracts the locally encoded important features, and GRUN reduces the vanishing gradient and exploding gradient problems. Finally, a hybrid gender recognition system is developed combining both generated feature vectors. The developed model has been tested with five bench mark and a simulated dataset to evaluate its performance and it is observed that combined feature vector provides more effective gender recognition system specially when transgender is considered as a gender type together with male and female.
Peptidomic Changes in The Milk of Water Buffaloes (Bubalus Bubalis) With Intramammary Infection By Non-Aureus Staphylococci
Authors: Addis Maria Filippa , Maffioli Elisa Margherita , Penati Martina , Albertini Mariangela , Bronzo Valerio , Piccinini Renata , Tangorra Francesco , Tedeschi Gabriella , Cappelli Giovanna , Vuolo Gabriele Di , Vecchio Domenico , De Carlo Esterina , Ceciliani Fabrizio 
Published: October 2021

Abstract
Mastitis by non-aureus staphylococci (NAS) is a significant issue in dairy buffalo farming. In a herd with subclinical NAS mastitis, we identified Staphylococcus microti as the predominant species. To assess milk protein integrity and investigate potential disease markers, we characterized 12 NAS-positive and 12 healthy quarter milk samples by shotgun peptidomics combining peptide enrichment and high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS). We observed significant changes in the milk peptidome. Out of 789 total peptides identified in each group, 49 and 44 were unique or increased in NAS-positive and healthy milk, respectively. In NAS-positive milk, the differential peptides belonged mainly to caseins, followed by milk fat globule membrane proteins (MFGMP) and by the immune defense/antimicrobial proteins osteopontin, lactoperoxidase, and serum amyloid A. In healthy milk, these belonged mainly to MFGMP, followed by caseins. In terms of abundance, peptides from MFGMP and immune defense protein were higher in NAS-positive milk, while peptides from caseins were higher in healthy milk. These findings highlight the impact of NAS on buffalo milk quality and mammary gland health, even when clinical signs are not evident, and underscore the need for clarifying the epidemiology and relevance of the different NAS species in this dairy ruminant.