bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Factors and Their Relative Importance Analysis in Peruvian Gold Mining Companies’ Stock Price
Authors: Vilcarromero Arbulu Jose Fernando , Castilla Raimundo Jorge Luis , Venegas Rodriguez Pedro Bernabe , Santillan Zapata Nivardo Alonzo , Deza Quispe Jimmy Alberth 
Published: January 2021

The current research examined the relationship and relative importance of financial regressors on Peruvian gold mining companies´ stock prices from 2009 to 2018. Chosen regressors were earnings per share, dividend per share and dividend yield. Fixed effects analysis was employed for regression analysis and decomposition for the relative importance study. Assumptions of stationarity, independence, no-multicollinearity, homoscedasticity and specification were fulfilled. Also, the values of Owen and Shapley were employed for decomposing . It was found that earnings per share and dividend per share had a positive effect on the dependent variable; while dividend yield was found to be negatively related to stock price. Moreover, by the usage of decomposition it was noticed that the order of regressors importance was earnings per share, dividend per share and dividend yield. Then, it was stated that gold mining stock prices had a high dependence on profits and dividend payments in the analyzed period which can be related to the bearer’s expectations.
Comparison of Native and Regenerated Antheraea Pernyi Silk Fibroin
Authors: DUAN Yu , CHEN Xin , SHAO Zhengzhong 
Published: January 2021

The regenerated Antheraea pernyi silk fibroin (RASF) was harvested by dissolving the silk fibers in a calcium nitrate solution. XRD result demonstrated that both native and regenerated Antheraea pernyi silk fibroin involved the α-helix conformation, and DTG curves showed that their thermal decompositions were quite similar and proceeded three steps. However, rheological measurements figured out that the molecule weight of RASF decreased from 246 kDa to 199 kDa, comparing with native Antheraea pernyi silk fibroin. Also, the tensile properties of the RASF film, which were the same to those of regenerated Bombyx mori silk fibroin film, were observed.
Study on the Biotribological Properties of Ti6Al7Nb and Ultra High Density Molecular Weight Polyethylene at Different Lubricant Temperature
Authors: WANG Songquan , HU Ningning , YANG Shuo , HAN Da , SUN Deqi , ZHANG Dekun 
Published: January 2021

Higher frictional heat will be produced during the service process of artificial hip joint prosthesis in vivo than natural joint, which would cause the rise of the temperature of synovial fluid and the change of the wear resistance of prosthetic materials. In this work, the biotribological properties of ZrO2/Ti6Al7Nb and ZrO2/UHMWPE pairs at different lubricant temperatures were investigated. The results show that there is a strong correlation between the wettability and average friction coefficient of Ti6Al7Nb, while there is also a strong correlation between the wettability and mass loss of UHMWPE. The wear loss of Ti6Al7Nb and UHMWPE decreases gradually and the friction coefficient increases gradually as the lubricant temperature rises from 20 ℃ to 46 ℃, which is mainly affected by the precipitation process of protein. As a protective layer, it can reduce the wear rate, but as a third body, it can participate in the friction process and increase the friction coefficient. The characteristics of lubricant change greatly at 60 ℃, but the increase of temperature is not the only reason for the precipitation of synovial protein. The synergistic effect with the friction process results in a significant change on the wear mechanism of Ti6Al7Nb and UHMWPE under this condition. The wear mechanism of Ti6Al7Nb is mainly abrasive wear and adhesion wear at different lubricant temperature. With the increase of lubricant temperature, the proportion of adhesion wear mechanism becomes larger. Due to the low thermal deformation temperature and thermal conductivity, the wear mechanism of UHMWPE changed obviously at 60 ℃, and the wear morphology is mainly plastic deformation.
A preliminary comparative study of percutaneous CT-guided cryoablation with surgical resection for osteoid osteoma
Authors: Meng Liangliang , Zhang Xiao , Xu Ruijiang , Wu Bin , Zhang Xiaobo , Wei Yingtian , Li Jing , Shan Husheng , Xiao Yueyong 
Published: January 2021

Background
The traditional treatment for osteoid osteoma is the nidus’ surgical resection, which was difficult to eradicate with more invasive and complications because of osteosclerosis surrounding the nidus. This study aimed to analyze the efficacy and safety of percutaneous CT-guided cryoablation of osteoid osteoma at different sites (especially refractory sites such as the spine).

Methods
Fifteen patients with osteoid osteoma who underwent cryoablation at our institution were analyzed retrospectively on their imaging data and clinical visual analog scale (VAS) pain scores before and after the procedure. Fifty-three patients underwent surgical resection during the period were also included in this study as a control group. Treatment efficacy was assessed primarily by comparing the differences in VAS scores at different time points in each group of patients by paired-sample t-test. Differences in length of hospital stay and complications between the two groups were also compared.

Results
The technical success rate was 100% in both the cryoablation and surgical resection group. Cryoablation had a significantly shorter hospitalization time than surgery (p = 0.001). Clinically, the post-operative VAS scores were all significantly improved compared to the pre-operative period, and the clinical cure was achieved in both groups. Surgical operations had more complications than cryoablation, although there was no significant difference. In the group of cryoablation, only one patient had mild numbness of the left lower extremity, which relieved itself; two patients had mild post-operative pain. No patients in the cryoablation group experienced recurrence during the follow-up period. In the surgery group, three of the patients experienced massive bleeding (>500 ml), and two underwent transfusion therapy. Only one patient in the surgical resection group experienced a recurrence at 29 months postoperatively and underwent a second resection. All patients had local scars on the skin after surgical resection.

Conclusion
Cryoablation is a minimally invasive, safe, and effective treatment strategy for osteoid osteoma, and is fully comparable to surgical resection.
Isolation, production and application of fibrinolytic enzyme from fermented food sources
Authors: Singh Nitika , Shera Shailendra Singh 
Published: January 2021

The accumulation of the fibrin in bacterial fibrinolytic enzymes finds applications to treat and prevent cardiovascular diseases which fail in hemostasis that leads to the formation of undesirable blood clots in the blood vessels leading to condition called thrombosis. The fibrinolytic enzymes from food grade organisms are useful for thrombolytic therapy. Conventional thrombolytic agents such as streptokinase, nattokinase etc. Nattokinase is one such fibrinolytic enzyme with a wide range of applications in Pharmaceutical industry, health care and medicine etc. Hence, potent blood-clot dissolving protein used for the treatment of cardiovascular diseases is produced by the bacterium Bacillus subtilis during the fermentation of soybeans to produce Natto. The health benefits of some fermented foods are synthesis of nutrients, prevention of cancer, diabetes due to presence of functional microorganisms, which possess probiotics properties, antimicrobial, antioxidant, etc. The first report of fibrinolytic enzyme production of cow dung used as a cheap substrate from Bacillus species in SSF has been given earlier. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. The purification and properties of these fibrinolytic proteases is discussed, and the use of fibrinolytic enzyme. In order to obtain Bacillus species producing fibrinolytic enzymes, the fermented food sample such as sprouted grain and processed grain etc were used. The heat tolerant isolates initially were selected for catalase test. Fibrinolytic activity of the selected isolates was determined by using Fibrin plate assay. From the above work, it can be concluded that the fibrinolytic enzyme produced by Bacillus from fermented food samples had the ability to degrade the fibrin and hence can be used for functional food formulation.
Antioxidant and Ethnobotanical Study of Strychnos icaja Baillon (Loganiaceae) from Gabon
Authors: Samseny Reine Raïssa Rolande Aworet , Mengome Line-Edwige , Angone Sophie Aboughe 
Published: January 2021

Aim: In plants, are found large amount of vitamin (A, B, C, E), mineral (Zn, Cu, Se) and biochemical (glutathione, taurine, phenol acids) substances which also have a well-known antioxidant power. These substances have phytotheraptic applications in the fight against aging caused by oxidative stress and are oxidative component of acute pathologies: (infectious, traumatic, inflammatory and allergic). Strychnos icaja Baillon (Loganiaceae) is a tropical shrub common in the tropical forest of Central Africa. Strychnos species is mainly used by the local population as an arrow or ordeal poison, for treatment of haemorrhoids and malaria by the Pygmies tribes from Cameroon due to its magic-medical property. This study determined the medicinal uses of Strychnos and assessed its antioxidant potential.
Methodology: Extracts of alkaloids, aqueous, ethyl acetate, dichloromethane and butanol from Strychnos were evaluated for their antioxidant properties. An ethnobotanical survey of 20 traditional therapists was carried to obtain the medicinal uses of the root of Strychnos icaja.
Results: 1,1-diphenyl-2-picryl-hydrazyl (DPPH) test shows good antiradical activity. Antioxidant activity by the ferric reducing antioxidant power (FRAP) test, show that Strychnos total alkaloids of the roots have a value of 5.94 ± 0.14mmol EAA/g that is significantly close from Ascorbic acid (5.86 ± 0.51 mmol EAA/g). The results of survey of traditional therapists identified six indications of this plant, namely in the treatment of haemorrhoids, against ear infections, male urethritis, rheumatic and dental pain and sterility in women.
Conclusion: The Strychnos icaja possesses antioxidant activity, this can find use in the treatment of inflammatory diseases.
Sabicea brasiliensis Wernham: Antioxidant Activity, Proliferative Effect and Modulation of Vascular Adenine Nucleotides Metabolism
Authors: Oliveira Douglas Souza , Correia Mikaelle Costa , Araújo Bruna Juber de , Silva Fernanda Cardoso da , Lima Paula Marynella Alves Pereira , Gomes Marcos de Souza , Araújo Thaise Gonçalves de , Fürstenau Cristina Ribas 
Published: January 2021

Aims: Study addressed the antioxidant activity (AA) of Sabicea brasiliensis roots crude extract (CE), ethyl acetate (EAF), and hydro-methanolic (HMF) fractions, and its impact on cell viability and adenine nucleotide hydrolysis in vascular A7r5 cells.
Materials and Methods: AA of CE, EAF and HMF were determined by the inhibition of the DPPH and ABTS radicals. Total phenolic content was evaluated by Folin-Ciocalteau. Cell viability was determined by MTT assay at different concentrations (62.5; 125; 250 and 500 μg·mL-1) of EAF and HMF after 24, 48 and 72 h. Ectonucleotidase activities were evaluated by colorimetric methods after 48 h EAF or HMF treatment.
Results: The highest AA was observed for CE (76%), followed by EAF (46%) and HMF (23%). Phenolic content followed the same pattern. After 48 h, EAF increased A7r5 vascular cells viability by 40%, 40%, 62% and 25% at distinct concentrations, respectively; while HMF augmented it by 50% (500 μg·mL−1). Finally, after 48 h EAF (500 μg·mL−1) decreased about 50% of ATP and ADP metabolism while HMF inhibited 56 and 59% the hydrolysis of NPP substrate (at 125 and 250 μg·mL−1).
Conclusion: Study confirmed the high AA of S. brasiliensis, which influences vascular cells proliferation and purines metabolism, pointing to potential cellular pathways that may support the popular use of this plant.
Effect of Short and Long Term Restraint Stress on the Histology of Liver, Kidney and Suprarenal Gland in Albino Mice during Postweaning Period
Authors: Said Othman Hakum , Okafor Chukwuma J. , Haji Hassan Thabit , Babu Prakash B. , Nayak Vanisri S. , Obianagha Nkem F. , Galano Emilio Stivens 
Published: January 2021

On exposure to stress and for the sake of survival, cells make adjustments with the changes in their environment to the physiologic needs and non-lethal pathologic injury. When the environmental changes are greater than the capacity of the cell to maintain normal homeostasis the cell undergoes acute cell injury. If the injury or insult is removed on time, or the cell can adapt and withstand the injury, the term reversible injury is applied. The processes of adaptation include decreasing or increasing their size, increasing their number, or changing the pathway of phenotypic differentiation of cells.
In the present study, albino mice of postweaning age of BALB C strain (21 days old) were exposed to short term (5 days) and long term (21 days) restraint stress to evaluate any histological changes in the kidney, liver, and suprarenal gland.
Mice subjected to long term stress showed in the kidney degeneration of the cells of the glomerulus and the convoluted tubules. In the liver, they showed congested sinusoids and the presence of some fatty change, whereas in the suprarenal gland mice subjected to 21 days of stress showed moderate hypertrophy and hyperplasia of the adrenal cortex with the presence of moderate lipoid deposits when compared to controls. The overall effect on short term stress was mild when compared to exposure to 21 days stress
Long term stress causes degeneration in hepatic cells, infiltration in the liver, degeneration of glomerulus, Bowman’s capsule, convoluted tubules in the kidney which could lead to nephrotoxicity. In the suprarenal gland, long term stress induces hypertrophy of the adrenal cortex. These morphological changes can explain the impaired immunity which develops in organisms that are exposed to chronic stress.
Occupancy models including local and landscape variables are useful to assess the distribution of a salamander species at risk
Authors: Oropeza‐Sánchez Marco Tulio , Suazo‐Ortuño Ireri , Benítez‐Malvido Julieta , Munguía‐Steyer Roberto 
Published: January 2021

AbstractNumerous amphibian species are at risk of extinction worldwide. Therefore, reliable estimations of the distribution and abundance of these species are necessary for their conservation. Generally, amphibians are difficult to detect in the wild, which compromises the accuracy of long‐term population monitoring and management. Occupancy models are useful tools to assess how environmental variables, at a local and at a landscape scale, affect the distribution and abundance of organisms taking into account species imperfect detectability. In this study, we evaluated with an environmental multiscale approach the seasonal variation of the occupation area of the threatened salamander, Ambystoma ordinarium along its distribution range. We obtained readings in 60 streams of physicochemical variables associated with habitat quality and landscape features. We found that detection and occupation probability of A. ordinarium are seasonally associated with different environmental variables. During the dry season, detectability was positively associated with temperature and stream depth, whereas occupancy was positively associated with the proportion of crops in the landscape and stream elevation. In the rainy season, the detection probability was not explained by any variable considered, and occupancy was negatively associated with stream's electrical conductivity and dissolved oxygen. Based on the estimation of occupied sites, we showed that A. ordinarium presents a more restricted distribution range than previously projected. Therefore, our results reveal the importance of evaluating the accuracy of distribution estimates for the conservation of threatened species as A. ordinarium.
Characterization of transcripts emanating from enhancer Eβ of the murine TCRβ locus
Authors: Uddin Faizan , Srivastava Madhulika 
Published: January 2021

Enhancers are well established as critical regulators of gene expression, but the mechanisms underlying the molecular basis of their specificity and activity are only partly understood. One of the most exciting recent observations is the discovery of enhancer RNA (eRNA), a class of noncoding RNAs derived from enhancer regions. Transcription of developmentally regulated enhancers has been observed to be associated with their active state. The nature of transcripts (eRNA) and their functional attributes are diverse and context dependent. The majority of eRNA are nonpolyadenylated and present in low abundance owing to their low stability, and may represent transcriptional noise. However, some eRNAs have been reported to be reasonably long and stable, are enriched in nuclei, exhibit tissue‐specific expression and may contribute to enhancer function. Transcription of enhancers has been postulated to mediate enhancer function through either the act of transcription or via the transcribed RNA per se and is a useful feature to be analysed to understand mechanisms underlying enhancer activity. Enhancer Eβ at the murine TCRβ locus has been reported to exhibit enhanced occupancy of RNA polymerase II in developing thymocytes. Here, we investigated the transcriptional potential of Eβ in developing thymocytes and detected overlapping bidirectional transcripts at Eβ ranging between 0.7 and 1.7 kb. These noncoding transcripts are capped, polyadenylated, nuclear and expressed specifically in thymocytes. Delineation of these characteristics is important to further investigate their functional roles in mediating enhancer activity.
The clinical impact of removing rectal gas on high‐dose‐rate brachytherapy dose distributions for gynecologic cancers
Authors: Vergalasova Irina , Ennis Ronald D. , Sayan Mutlay , Liu Bo , Yue Ning J. , Hathout Lara 
Published: January 2021

AbstractPurposeTo evaluate the impact of gas removal on bladder and rectal doses during intracavitary and interstitial high‐dose‐rate brachytherapy (HDRB) for gynecologic cancers.Material and MethodsFifteen patients treated with definitive external beam radiation followed by HDRB for gynecologic cancers for a total of 21 fractions, presented with a significant amount of rectal gas at initial CT imaging (CTGAS) after implantation. The gas was removed via rectal tubing followed by subsequent scan acquisition (CTCLINICAL), which was used for planning and treatment delivery. To assess the effect of gas removal on dosimetry, both bladder and rectum volumes were recontoured on CTGAS. In order to evaluate the clinical impact on the total Equivalent‐Dose‐in‐2Gy‐fraction (EQD2), each fraction was also replanned to maintain clinically delivered target coverage (HRCTV D90). EQD2 D2cm3 for bladder and rectum were compared between plans. The Wilcoxon signed rank test was performed to evaluate statistically significant differences for all comparisons (P < 0.05).ResultsMean rectum and bladder Dmax, D0.1cm3, D1cm3, D2cm3, and D5cm3 were significantly different between CTGAS and CTCLINICAL. The mean percent increases on CTGAS for bladder were 12.3, 8.4, 9.9, 10.2, and 9.5% respectively and for rectum were 27.0, 19.6, 18.1, 18.5, and 19.4%, respectively. After replanning with CTGAS to maintain HRCTV D90 EQD2, bladder and rectum EQD2 D2 cm3 resulted in significantly higher doses. The mean EQD2 D2 cm3 difference was 2.4 and 4.1 Gy for bladder and rectum, revealing a higher impact of gas removal on rectal DVH.ConclusionRectal gas removal resulted in statistically significant differences for both bladder and rectum. The resulting larger EQD2 D2 cm3 for bladder and rectum demonstrates that if patients were treated without removing gas, target coverage would need to be sacrificed to satisfy the rectum constraints and prevent toxicities. Therefore, this study demonstrates the importance of gas removal for gynecologic HDRB patients.
Comprehensive Assessment of Quality of Life, Functioning, and Mental Health in Children With Juvenile Idiopathic Arthritis and Noninfectious Uveitis
Authors: McDonald Joseph , Cassedy Amy , Altaye Mekibib , Andringa Jennifer , Cooper Ashley M. , Drews‐Botsch Carolyn , Engelhard George , Hennard Theresa , Holland Gary N. , Jenkins Kirsten , Lambert Scott R. , Lipscomb Jessi , McCracken Courtney , McCurdy Deborah K. , Mwase Najima , Prahalad Sampath , Shantha Jessica , Stahl Erin , Utz Virginia Miraldi , Walker A. Adrienne , Yeh Steven , Angeles‐Han Sheila T. 
Published: January 2021

ObjectivePediatric uveitis can lead to sight‐threatening complications and can impact quality of life (QoL) and functioning. We aimed to examine health‐related QoL, mental health, physical disability, vision‐related functioning (VRF), and vision‐related QoL in children with juvenile idiopathic arthritis (JIA), JIA‐associated uveitis (JIA‐U), and other noninfectious uveitis. We hypothesized that there will be differences based on the presence of eye disease.MethodsA multicenter cross‐sectional study was conducted at four sites. Patients with JIA, JIA‐U, or noninfectious uveitis were enrolled. Patients and parents completed the Pediatric Quality of Life Inventory (PedsQL; health‐related QoL), the Revised Childhood Anxiety and Depression Scale (RCADS; anxiety/depression), the Childhood Health Assessment Questionnaire (C‐HAQ; physical disability), and the Effects of Youngsters' Eyesight on Quality of Life (EYE‐Q) (VRF/vision‐related QoL). Clinical characteristics and patient‐reported outcome measures were compared by diagnosis.ResultsOf 549 patients, 332 had JIA, 124 had JIA‐U, and 93 had other uveitis diagnoses. Children with JIA‐U had worse EYE‐Q scores compared to those with JIA only. In children with uveitis, those with anterior uveitis (JIA‐U and uveitis only) had less ocular complications, better EYE‐Q scores, and worse C‐HAQ and PedsQL physical summary scores compared to those with nonanterior disease. In children with anterior uveitis, those with JIA‐U had worse PedsQL physical summary and C‐HAQ scores than anterior uveitis only. Further, EYE‐Q scores were worse in children with bilateral uveitis and more visual impairment. There were no differences in RCADS scores among groups.ConclusionWe provide a comprehensive outcome assessment of children with JIA, JIA‐U, and other uveitis diagnoses. Differences in QoL and function were noted based on underlying disease. Our results support the addition of a vision‐specific measure to better understand the impact of uveitis.