bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Correlations Delirium and other Comorbid in Elderly with COVID-19 Infection
Authors: Putra Khoirun Mukhsinin , Nur Riviati  , Djunaidi AR  
Published: June 2021

Background. Delirium is a common condition in geriatric patients. One of the trigger factors for this condition is an infection, such as COVID-19 infection. Elderly with COVID-19 show atypical symptoms such as delirium. Elderly patients with COVID-19 who present with delirium, either as a primary symptom or showing symptoms or signs, have a poor prognosis. This study were aimed to presents covid-19 elderly patient with comorbid delirium.
Case presentation. A 77-year-old woman with disorientation for one day came to Emergency Department with her family. She had no history of headaches, blurred vision, or seizures. However, she had a fever, did not want to eat for three days, and had a purulent decubitus ulcer. The patient was diagnosed with acute delirium syndrome, confirmed COVID-19 with sepsis, malnutrition, hypercoagulation, grade III decubitus ulcer, suspected dementia, immobilization, total dependence. The patient admitted to the isolation ward. The patient had meropenem 500 mg every 12 hours, anticoagulants and favipiravir according to the dose and parenteral nutrition.
Conclusion. Patients with COVID-19 who present with delirium, either as a primary symptom or presenting symptoms or signs, have a worse outcome. Delirium relationship with comorbid factors can increase mortality and morbidity in the elderly with COVID-19.
V Jornada de Enfermagem do INCA
Authors: Instituto Nacional de Câncer José Alencar Gomes da Silva  
Published: June 2021

Tema: "A Ciência e a Arte de Cuidar".
Resumos escolhidos para publicação. Nessa edição, os títulos foram: Câncer de cólon em criança: um desafio para a enfermagem; Comportamento preventivo frente ao câncer do colo uterino entre mulheres trabalhadoras de uma Região Noroeste do Estado do Paraná; Associação entre qualidade de vida e conforto de pessoas com câncer avançado em cuidados paliativos em domicílio; Integração ensino-serviço no atendimento ao paciente com câncer.
NUMERICAL AND GRAPHICAL RESULTS OF FINITE SYMMETRIC INVERSE (I_{n}) AND FULL (T_{n}) TRANSFORMATION SEMIGROUPS
Authors: Kehinde R. , Abdulazeez O. H. 
Published: June 2021

Supposed is a finite set, then a function is called a finite partial transformation semigroup , which moves elements of from its domain to its co-domain by a distance of where . The total work done by the function is therefore the sum of these distances. It is a known fact that and . In this this research paper, we have mainly presented the numerical solutions of the total work done, the average work done by functions on the finite symmetric inverse semigroup of degree , and the finite full transformation semigroup of degree , as well as their respective powers for a given fixed time in space. We used an effective methodology and valid combinatorial results to generalize the total work done, the average work done and powers of each of the transformation semigroups. The generalized results were tested by substituting small values of and a specified fixed times in space. Graphs were plotted in each case to illustrate the nature of the total work done and the average work done. The results obtained in this research article have an important application in some branch of physics and theoretical computer science
THE INHIBITING FACTORS IN THE IMPLEMENTATION OF WOMEN AND CHILDREN PROTECTION UNIT’S ROLESS IN LAW ENFORCEMENT OF IMMORAL CRIMINAL ACT COMMITTED BY THE CLOSEST ADULTS TO MINORS IN THE JURISDICTION OF KEPAHIANG POLICE RESORT
Authors: Sidabutar Davinsi Josie , Karo Lidia Br , Herlambang Herlambang 
Published: June 2021

The increase in violence committed by parents and the closest adults to children brings a new concept that must be understood together where violence against children is not only a trivial matter and the private sphere, but has become the state and the public problem. Based on the facts and data that showed the rampant violence against children that often occurs in the area of Kepahiang Regency, namely, violence committed by parents and the closest adults to children, it becomes necessary for the efforts to protect children to be maximized. The protection efforts must be carried out by the police, especially by the Women and Children Service Unit. The Women and Children Service Unit also has main tasks contained in Article 3 of KAPOLRI Regulation Number 10 of 2007 concerning the Organization and Work Procedures of the Women and Children Service Unit within the Indonesian National Police environment. This study was conducted to obtain an overview, to understand and to analyze the factors inhibiting the implementation of the roles of Women and Children Protection Unit in law enforcement of immorality criminal acts committed by the closest adult to minors in the jurisdiction of Kepahiang Police Resort. The method applied in this study was an empirical juridical approach with qualitative analysis. The result of the study stated that the inhibiting factors in the implementation of the roles of Women and Children Protection Unit in law enforcement of immoral criminal acts committed by the closest adults to minors in the jurisdiction of Kepahiang Police Resort arose from internal and external factors.
ANALISIS PERIBAHASA MINANGKABAU DI PASAMAN BARAT KAJIAN BENTUK FUNGSI DAN MAKNA
Authors: Saputra Danil , Suryadi Suryadi , Supadi Supadi 
Published: June 2021

Tujuan penelitian ini adalah untuk mendeskripsikan bentuk peribahasa Minangkabau, fungsi peribahasa Minangkabau, serta makna peribahasa Minangkabau yang ada di Pasaman Barat. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Sumber data dalam penelitian ini adalah tuturan yang mengandung peribahasa yang diperoleh dari informan yang terdiri atas tokoh masyarakat. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah teknik wawancara, teknik rekam dan terknik catat, serta teknik simak. Langkah-langkah analisis data dalam penelitian ini adalah transkripsi data, identifikasi data, klasifikasi data, interpretasi data, dan membuat kesimpulan akhir. Hasil penelitian ini menunjukan bahwa peribahasa Minangkabau memiliki 8 bentuk peribahasa yaitu (1) kiasan, (2) mamang, (3) pemeo, (4) tamsil, (5) ibarat, (6) kata-kata arif, (7) petatah-petitih, dan (8) perumpamaan. Peribahasa Minangkabau memiliki 5 fungsi yaitu (1) sebagai media pendidikan dan pedoman tingkah laku, (2) sebagai pengatur aspek-aspek kehidupan bermasyarakat, (3) sebagai sumber hukum, pengasuh pranata sosial, pengawas dan pengukuh norma-norma sosial, (4) sebagai lambang identitas budaya dan sumber informasi budaya, (5) sebagai media serta sarana retorika untuk mematahkan kata-kata lawan bicara (alat pertahanan diri). Peribahasa Minangkabau memiliki 7 makna atau nilai-nilai yang terkandung dalam peribahasa Minangkabau yaitu (1) teguh pendirian, (2) malu, (3) nilai etika, (4) tahu diri, (5) menjaga diri, (6) persatuan/mufakat, dan (7) kesabaran.
PROTECTION OF INTELLECTUAL PROPERTY FOR SOUND TREND MARKS
Authors: Олена Чомахашвілі  
Published: June 2021

A trade mark — denotation that is used in an order to distinguish commodities or services of one producer from commodities or services of other producer.Mainly there are two excellent properties of the registered trade mark. She must not mislead consumers in relation to a producer or place of production. By the legislation of Ukraine the set grounds for a refuse in registration of trade mark. These grounds are based, on indicated higher, properties of trade marks.Procedure of registration of trade mark in Ukraine is certain Law of Ukraine "On the guard of rights on signs for commodities and services" and by Rules of serve and consideration of requests.To voice denotations take different sounds such, as fragments of pieces of music, industrial, domestic, natural noises and their arbitrary combinations. In the world mostly as voice trademarks a call-sign register and illuminations of TV and radio stations, pronounced slogans of companies. In regard to voice trademarks on the first plan the phonetic constituent of this denotation goes out exactly.Sound denotations, as a rule, are represented as an ordinary musical record. Registration of verbal denotations is possible at the same time.Similar trademarks are often used in TV and radio adverting segment. Such voice denotations are clearly associated with a certain producer. Practically all voice trademarks passing state registration are fragments the music in a musical record, sometimes complemented by small verbal part. The terms of receipt of legal safeguard of voice trade marks are considered in the article. Practice of receipt of such rights is analyses. The examples of expediency of receipt of such guard are described. Problem aspects are educed in procedure of examining.The prognosis of probability of terms of increase of interest is done in voice trade marks. Set forth to recommendation on the improvement of some positions of normatively-legal acts in the field of rights on voice trade marks.
Copyright protection for computer programs
Authors: Zerov Konstiantyn 
Published: June 2021

Zerov K. Copyright protection for computer programs. The article discusses the main approaches to the legal protection of software, particularly computer programs, in accordance with the current legislation of Ukraine and foreign practices. It is concluded that copyright allows to adequately protect the forms of expression of a computer program: object and source codes of the program. It is noted that a computer program shall be protected if it is original in the sense that it is the author's own intellectual creation, and no other criteria shall be applied to determine its eligibility for protection in Ukraine. Like any other copyright object, a computer program has «legally indifferent» and «legally significant» elements of the form of expression. The legally indifferent elements of a computer program should include a) elements dictated by the efficiency of a computer program; (b) elements that are dictated by external factors; and (c) elements that the original programmer had taken from the public domain. The main approaches to the use (copying) of the source or object code of computer programs as part of other computer programs are given: «literal copying» and «non-literal copying.» It is concluded that «non-literal copying» of a computer program cannot violate the copyright law in Ukraine since the ideas and principles on which any element of a computer program is based are not protected by copyright. It is assumed that the modification of a computer program by eliminating technical means of protection and further use of computer program gives grounds to qualify such actions as two separate types of copyright infringement: infringement of the copyright holder's property rights and deliberately circumventing technical means of copyright protection. It is noted that in some scenarios, theuse of works under the limitation of copyright without circumvention of technical means may be impossible. The proposal to legislatively provide for the possibility of a person who has the right to freely use work to contact the copyright holder with a request to remove technical means solely for such use, as well as cases of permissible circumvention of technical means, has been made.Keywords: computer program, copyright, literal copying, non-literal copying
Beclin-1–Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis
Authors: Nikouee Azadeh , Kim Matthew , Ding Xiangzhong , Sun Yuxiao , Zang Qun S. 
Published: June 2021

ObjectiveWe previously demonstrated that promoting Beclin-1–dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis. In this study, we applied both genetic and pharmacological approaches to evaluate whether Beclin-1 activation improves sepsis outcomes in a model of pneumonia-induced sepsis.MethodsSepsis was induced in mice by Klebsiella pneumoniae infection via intubation, and outcomes of clinical sickness scores, systemic infection, inflammation, survival, and pulmonary pathology were examined. Evaluation of Beclin-1 activation was achieved by comparing strains of C57BL/6J wild type and Becn1F121A that carries a transgenic expression of Beclin-1–active mutant F121A, and by comparing animal groups treated with Beclin-1–activating peptide, Tat-beclin-1 peptide (TB-peptide), or with vehicle control. The status of autophagy in the lung tissue was examined in autophagy reporter mice, CAG-RFP-EGFP-LC3, by fluorescence microscopy.ResultsPulmonary infection by K. pneumoniae produced an insufficient, maladaptive autophagy in the lung. Activation of Beclin-1 by forced expression of active mutant Becn1F121A or by treatment with TB-peptide enhanced autophagy and significantly reduced sickness scores, systemic infection, and circulating and pulmonary cytokine production. Both approaches demonstrated notable benefits in limiting post-infection pathogenesis in the lung, such as decreases in alveolar congestion, hemorrhage, infiltration of inflammatory cells, and alveolar wall thickness.ConclusionData suggest that targeted activation of Beclin-1 alleviates adverse outcomes of pneumonia-induced sepsis, and thus, possess a therapeutic potential.
Deciphering Historical Water-Quality Changes Recorded in Sediments Using eDNA
Authors: Sun Jing , Chen Xueping , Yu Juan , Chen Zheng , Liu Lihua , Yue Yihong , Fu Zhiwei , Yang Ming , Wang Fushun 
Published: June 2021

Reservoir sediments harbor abundant bacterial communities that are sensitive to substances transferred from the water column and might record historic water quality in environmental DNA (eDNA). The unique bacterial community along the sediment profile were retrieved based on eDNA in a reservoir to investigate potential links between water quality and the microbial population on a long-time scale. Bacterial communities in sediment samples gathered into three clusters along the depth (depths of 18–38, 8–18, and 1–7 cm). These three sections accumulated during three periods in which water quality was recorded in history (the pristine stage, degraded stage and remediated stage). Sediment samples from the degraded stage had lower microbial community evenness and diversity and higher microgAMBI indices than the other two sections, suggesting that poor water quality during that period was recorded in sedimental eDNA. After decades of biogeochemical cycles, statistical analysis revealed that the main factors affecting the microbial community were bromine, chlorine, and high molecular-weight PAHs in sediments from the degraded stage. The relevant functional groups Dehalococcoidia, Gemmatimonadales, Sva0485, Burkholderiales and Xanthomonadales might be indicators of the historical loading of these pollutants. Amending the microgAMBI index with our functional group of pollution can better illustrate the significant long-term environmental changes caused by historic anthropogenic activities. In sediments from the pristine stage with less pollution input, DIC (dissolved inorganic carbon) from the karst landform was the dominant factor controlling microbial communities. Whereas, the surface sediments, which accumulated during the remediated stage, had more correlation with chemistry, such as sulfate and heavy metals, in the overlying water. Our research revealed that historical changes in the water condition, that can be affected by anthropogenic activities, can be depicted by changes in the bacterial communities stored in the sediment using sedimental eDNA. Assessments of the bacterial communities in the sediments, either by describing their biodiversity or using particular species as indicators, would be potential proxies to describe historical environmental development of microbial communities.
Prediction of Cadmium Transfer From Soil to Potato in Karst Soils, China
Authors: Liu Ke , Liu Hongyan , Zhou Xianyong , Chen Zhu , Wang Xulian 
Published: June 2021

Contamination of food with the heavy metal Cd is a significant global concern. In this study, a field survey was performed to investigate the characteristics of Cd transfer from soil to potato tubers (n = 105). The results showed that the bioaccumulation factor of the potato tuber ranged from about 0.1 to 1. The soil threshold of Cd derived from the cumulative probability distribution was 0.15 mg kg−1 in order to protect 95% of potatoes. Additionally, prediction models for Cd transfer were constructed based on soil properties and the concentration of CaCl2-extractable soil Cd. The results of the analysis showed that pH was the critical factor affecting Cd uptake by potatoes. Additionally, the R2 of different empirical models increased from 0.354 to 0.715 as the number of soil parameters was increased, and the predicted soil Cd concentration approached the measured values at values of about 0–15 mg kg−1. The results of this study suggest that the probability distribution method was stricter than the empirical prediction models for estimating the ecological risk of Cd contamination of potatoes in karst soils.
Further Evidence That OPG rs2073618 Is Associated With Increased Risk of Musculoskeletal Symptoms in Patients Receiving Aromatase Inhibitors for Early Breast Cancer
Authors: Hertz Daniel L. , Smith Karen Lisa , Zong Yuhua , Gersch Christina L. , Pesch Andrea M. , Lehman Jennifer , Blackford Amanda L. , Henry N. Lynn , Kidwell Kelley M. , Rae James M. , Stearns Vered 
Published: June 2021

BackgroundAromatase inhibitors (AI) reduce recurrence and death in patients with early-stage hormone receptor-positive (HR +) breast cancer. Treatment-related toxicities, including AI-induced musculoskeletal symptoms (AIMSS), are common and may lead to early AI discontinuation. The objective of this study was to replicate previously reported associations for candidate germline genetic polymorphisms with AIMSS.MethodsWomen with stage 0-III HR + breast cancer initiating adjuvant AI were enrolled in a prospective clinic-based observational cohort. AIMSS were assessed by patient-reported outcomes (PRO) including the PROMIS pain interference and physical function measures plus the FACT-ES joint pain question at baseline and after 3 and 6 months. For the primary analysis, AIMSS were defined as ≥ 4-point increase in the pain interference T-score from baseline. Secondary AIMSS endpoints were defined as ≥ 4-point decrease in the physical function T-score from baseline and as ≥ 1-point increase on the FACT-ES joint pain question from baseline. The primary hypothesis was that TCL1A rs11849538 would be associated with AIMSS. Twelve other germline variants in CYP19A1, VDR, PIRC66, OPG, ESR1, CYP27B1, CYP17A1, and RANKL were also analyzed assuming a dominant genetic effect and prespecified direction of effect on AIMSS using univariate logistic regression with an unadjusted α = 0.05. Significant univariate associations in the expected direction were adjusted for age, race, body mass index (BMI), prior taxane, and the type of AI using multivariable logistic regression.ResultsA total of 143 participants with PRO and genetic data were included in this analysis, most of whom were treated with anastrozole (78%) or letrozole (20%). On primary analysis, participants carrying TCL1A rs11849538 were not more likely to develop AIMSS (odds ratio = 1.29, 95% confidence interval: 0.55–3.07, p = 0.56). In the statistically uncorrected secondary analysis, OPG rs2073618 was associated with AIMSS defined by worsening on the FACT-ES joint pain question (OR = 3.33, p = 0.004), and this association maintained significance after covariate adjustment (OR = 3.98, p = 0.003).ConclusionCarriers of OPG rs2073618 may be at increased risk of AIMSS. If confirmed in other cohorts, OPG genotyping can be used to identify individuals with HR + early breast cancer in whom alternate endocrine therapy or interventions to enhance symptom detection and implement strategies to reduce musculoskeletal symptoms may be needed.
Urine NMR Metabolomics Profile of Preterm Infants With Necrotizing Enterocolitis Over the First Two Months of Life: A Pilot Longitudinal Case-Control Study
Authors: Picaud Jean-Charles , De Magistris Anna , Mussap Michele , Corbu Sara , Dessì Angelica , Noto Antonio , Fanos Vassilios , Cesare Marincola Flaminia 
Published: June 2021

Objective: To investigate changes in the urine metabolome of very low birth weight preterm newborns with necrotizing enterocolitis (NEC) and feed intolerance, we conducted a longitudinal study over the first 2 months of life. The metabolome of NEC newborns was compared with two control groups that did not develop NEC: the first one included preterm babies with feed intolerance, while the second one preterm babies with good feed tolerance.Methods: Newborns developing NEC within the 3 weeks of life were identified as early onset NEC, while the remaining as late onset NEC. Case-control matching was done according to the gestational age (±1 week), birth weight (± 200 g), and postnatal age. A total of 96 urine samples were collected and analyzed. In newborns with NEC, samples were collected before, during and after the diagnosis over the first 2 months of life, while in controls samples were collected as close as possible to the postnatal age of newborns with NEC. Proton nuclear magnetic resonance (1H NMR) spectroscopy was used for metabolomic analysis. Data were analyzed by univariate and multivariate statistical analysis.Results: In all the preterm newborns, urine levels of betaine, glycine, succinate, and citrate positively correlated with postnatal age. Suberate and lactate correlated with postnatal age in preterms with NEC and in controls with food intolerance, while N,N-dimethylglycine (N,N-DMG) correlated only in controls with good digestive tolerance. Preterm controls with feed intolerance showed a progressive significant decrease of N-methylnicotinamide and carnitine. Lactate, betaine, myo-inositol, urea, creatinine, and N,N-dimethylglycine discriminated late-onset NEC from controls with good feed tolerance.Conclusion: Our findings are discussed in terms of contributions from nutritional and clinical managements of patients and gut microbiota.
Radiomics Is Effective for Distinguishing Coronavirus Disease 2019 Pneumonia From Influenza Virus Pneumonia
Authors: Lin Liaoyi , Liu Jinjin , Deng Qingshan , Li Na , Pan Jingye , Sun Houzhang , Quan Shichao 
Published: June 2021

Objectives: To develop and validate a radiomics model for distinguishing coronavirus disease 2019 (COVID-19) pneumonia from influenza virus pneumonia.Materials and Methods: A radiomics model was developed on the basis of 56 patients with COVID-19 pneumonia and 90 patients with influenza virus pneumonia in this retrospective study. Radiomics features were extracted from CT images. The radiomics features were reduced by the Max-Relevance and Min-Redundancy algorithm and the least absolute shrinkage and selection operator method. The radiomics model was built using the multivariate backward stepwise logistic regression. A nomogram of the radiomics model was established, and the decision curve showed the clinical usefulness of the radiomics nomogram.Results: The radiomics features, consisting of nine selected features, were significantly different between COVID-19 pneumonia and influenza virus pneumonia in both training and validation data sets. The receiver operator characteristic curve of the radiomics model showed good discrimination in the training sample [area under the receiver operating characteristic curve (AUC), 0.909; 95% confidence interval (CI), 0.859–0.958] and in the validation sample (AUC, 0.911; 95% CI, 0.753–1.000). The nomogram was established and had good calibration. Decision curve analysis showed that the radiomics nomogram was clinically useful.Conclusions: The radiomics model has good performance for distinguishing COVID-19 pneumonia from influenza virus pneumonia and may aid in the diagnosis of COVID-19 pneumonia.