bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptance of a Smartphone-Based Visual Field Screening Platform for Glaucoma: Pre-Post Study
Authors: Nida Esmael Kedir , Bekele Sisay , Geurts Luc , Vanden Abeele Vero 
Published: July 2021

Background
Glaucoma, the silent thief of sight, is a major cause of blindness worldwide. It is a burden for people in low-income countries, specifically countries where glaucoma-induced blindness accounts for 15% of the total incidence of blindness. More than half the people living with glaucoma in low-income countries are unaware of the disease until it progresses to an advanced stage, resulting in permanent visual impairment.

Objective
This study aims to evaluate the acceptability of the Glaucoma Easy Screener (GES), a low-cost and portable visual field screening platform comprising a smartphone, a stereoscopic virtual reality headset, and a gaming joystick.

Methods
A mixed methods study that included 24 eye care professionals from 4 hospitals in Southwest Ethiopia was conducted to evaluate the acceptability of GES. A pre-post design was used to collect perspectives before and after using the GES by using questionnaires and semistructured interviews. A Wilcoxon signed-rank test was used to determine the significance of any change in the scores of the questionnaire items (two-tailed, 95% CI; α=.05). The questionnaire and interview questions were guided by the Unified Theory of Acceptance and Use of Technology.

Results
Positive results were obtained both before and after use, suggesting the acceptance of mobile health solutions for conducting glaucoma screening by using a low-cost headset with a smartphone and a game controller. There was a significant increase (two-tailed, 95% CI; α=.05) in the average scores of 86% (19/22) of postuse questionnaire items compared with those of preuse questionnaire items. Ophthalmic professionals perceived GES as easy to use and as a tool that enabled the conduct of glaucoma screening tests, especially during outreach to rural areas. However, positive evaluations are contingent on the accuracy of the tool. Moreover, ophthalmologists voiced the need to limit the tool to screening only (ie, not for making diagnoses).

Conclusions
This study supports the feasibility of using a mobile device in combination with a low-cost virtual reality headset and classic controller for glaucoma screening in rural areas. GES has the potential to reduce the burden of irreversible blindness caused by glaucoma. However, further assessment of its sensitivity and specificity is required.
Belatacept for Simultaneous Calcineurin Inhibitor and Chronic Corticosteroid Immunosuppression Avoidance
Authors: Kaufman Dixon B. , Woodle E. Steve , Shields Adele Rike , Leone John , Matas Arthur , Wiseman Alexander , West-Thielke Patricia , Sa Ting , King Eileen C. , Alloway Rita R. ,   for the BEST Study Group
Published: July 2021

Background and objectives
Immunosuppressive therapy in kidney transplantation is associated with numerous toxicities. CD28-mediated T-cell costimulation blockade using belatacept may reduce long-term nephrotoxicity, compared with calcineurin inhibitor–based immunosuppression. The efficacy and safety of simultaneous calcineurin inhibitor avoidance and rapid steroid withdrawal were tested in a randomized, prospective, multicenter study.

Design, setting, participants, & measurements
This study reports the 2-year results of a randomized clinical trial of 316 recipients of a new kidney transplant. All kidney transplants were performed using rapid steroid withdrawal immunosuppression. Recipients were randomized in a 1:1:1 ratio to receive belatacept with alemtuzumab induction, belatacept with rabbit anti-thymocyte globulin (rATG) induction, or tacrolimus with rATG induction. The composite end point consisted of death, kidney allograft loss, or an eGFR of <45 ml/min per 1.73 m2 at 2 years.

Results
The composite end point was observed for 11 of 107 (10%) participants assigned to belatacept/alemtuzumab, 13 of 104 (13%) participants assigned to belatacept/rATG, and 21 of 105 (21%) participants assigned to tacrolimus/rATG (for belatacept/alemtuzumab versus tacrolimus/rATG, P=0.99; for belatacept/rATG versus tacrolimus/rATG, P=0.66). Patient and graft survival rates were similar between all groups. An eGFR of <45 ml/min per 1.73 m2 was observed for nine of 107 (8%) participants assigned to belatacept/alemtuzuab, eight of 104 (8%) participants assigned to belatacept/rATG, and 20 of 105 (19%) participants assigned to tacrolimus/rATG (P<0.05 for each belatacept group versus tacrolimus/rATG). Biopsy sample–proven acute rejection was observed for 20 of 107 (19%) participants assigned to belatacept/alemtuzuab, 26 of 104 (25%) participants assigned to belatacept/rATG, and seven of 105 (7%) participants assigned to tacrolimus/rATG (for belatacept/alemtuzumab versus tacrolimus/rATG, P=0.006; for belatacept/rATG versus tacrolimus/rATG, P<0.001). Gastrointestinal and neurologic adverse events were less frequent with belatacept versus calcineurin-based immunosuppression.

Conclusions
Overall 2-year outcomes were similar when comparing maintenance immunosuppression using belatacept versus tacrolimus, and each protocol involved rapid steroid withdrawal. The incidence of an eGFR of <45 ml/min per 1.73 m2 was significantly lower with belatacept compared with tacrolimus, but the incidence of biopsy sample–proven acute rejection significantly higher.

Clinical Trial registry name and registration number:
Belatacept Early Steroid Withdrawal Trial, NCT01729494
Effect of Hemodiafiltration on the Progression of Neuropathy with Kidney Failure
Authors: Kang Amy , Arnold Ria , Gallagher Martin , Snelling Paul , Green Julianne , Fernando Mangalee , Kiernan Matthew C. , Hand Samantha , Grimley Kim , Burman Jenny , Heath Anne , Rogers Kris , Bhattacharya Amritendu , Smyth Brendan , Bradbury Thomas , Hawley Carmel , Perkovic Vlado , Krishnan Arun V. , Jardine Meg J. 
Published: July 2021

Background and objectives
Neuropathy is a common complication of kidney disease that lacks proven disease-modifying treatments. Hemodiafiltration improves clearance of uremic toxins and is associated with better nerve function than hemodialysis. We aimed to determine whether hemodiafiltration reduces the progression of neuropathy in people receiving hemodialysis.

Design, setting, participants, & measurements
The Filtration in the Neuropathy of End-Stage Kidney Disease Symptom Evolution (FINESSE) study was an open-label, blinded end point assessment, controlled trial that randomized maintenance hemodialysis recipients to hemodiafiltration or high-flux hemodialysis for 48 months or until death or cessation of dialysis at four study centers. The primary outcome was the mean change in the yearly modified total neuropathy score from baseline, with time points weighted equally.

Results
A total of 124 participants were randomized and followed for a mean of 41 months. At baseline, neuropathy was present in 91 (73%) participants (modified total neuropathy score greater than or equal to two), and 38 (31%) had moderate to severe neuropathy (modified total neuropathy score 9–28). Convection volume in the hemodiafiltration arm was a median of 24.7 (interquartile range, 22.4–26.5) L. The mean modified total neuropathy score (SEM) worsened by 1.7 (0.4)/28 and 1.2 (0.4)/28 in the hemodiafiltration and hemodialysis groups, respectively, with a mean difference of 0.5 (95% confidence interval, −0.7 to 1.7; P=0.37). There was no difference in survival (hazard ratio, 1.24; 95% confidence interval, 0.61 to 2.51; log rank P=0.55) or any of the prespecified adverse events. There was no difference between groups in the number of participants who suffered an adverse event adjusted by follow-up time (relative risk, 1.05; 95% confidence interval, 0.83 to 1.32; P=0.68).

Conclusions
Neuropathy is still a common complication of kidney disease without disease-altering therapy. Hemodiafiltration did not affect neuropathy progression compared with hemodialysis.

Clinical Trial registry name and registration number:
Filtration in the Neuropathy of End-Stage Kidney Disease Symptom Evolution (FINESSE), ACTRN12609000615280
Preparation for Emergency Remote Teaching
Authors: Saqlain Nadeem 
Published: July 2021

Abstract
Due to COVID-19, almost all educational institutions were temporarily closed across the globe. As a result, many educators have focused on delivering courses through emergency remote teaching. Preparation for remote teaching was itself a great challenge. In this reflective paper, I have presented my own experience of preparation for emergency remote teaching for one of my courses in one of the Canadian universities. I have mentioned in the paper the factors that were helpful in the preparation for remote teaching such as my own background knowledge of online learning, training for remote teaching, designing and developing the course, using synchronous and asynchronous, engaging students, and presences.
The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58
Authors: Mosenzon Ofri , Wiviott Stephen D. , Heerspink Hiddo J.L. , Dwyer Jamie P. , Cahn Avivit , Goodrich Erica L. , Rozenberg Aliza , Schechter Meir , Yanuv Ilan , Murphy Sabina A. , Zelniker Thomas A. , Gause-Nilsson Ingrid A.M. , Langkilde Anna Maria , Fredriksson Martin , Johansson Peter A. , Bhatt Deepak L. , Leiter Lawrence A. , McGuire Darren K. , Wilding John P.H. , Sabatine Marc S. , Raz Itamar 
Published: July 2021

OBJECTIVE
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve albuminuria in patients with high cardiorenal risk. We report albuminuria change in the Dapagliflozin Effect on Cardiovascular Events (DECLARE-TIMI 58) cardiovascular outcome trial, which included populations with lower cardiorenal risk.

RESEARCH DESIGN AND METHODS
DECLARE-TIMI 58 randomized 17,160 patients with type 2 diabetes, creatinine clearance &gt;60 mL/min, and either atherosclerotic cardiovascular disease (CVD; 40.6%) or risk-factors for CVD (59.4%) to dapagliflozin or placebo. Urinary albumin-to-creatinine ratio (UACR) was tested at baseline, 6 months, 12 months, and yearly thereafter. The change in UACR over time was measured as a continuous and categorical variable (≤15, &gt;15 to &lt;30, ≥30 to ≤300, and &gt;300 mg/g) by treatment arm. The composite cardiorenal outcome was a ≥40% sustained decline in the estimated glomerular filtration rate (eGFR) to &lt;60 mL/min/1.73 m2, end-stage kidney disease, and cardiovascular or renal death; specific renal outcome included all except cardiovascular death.

RESULTS
Baseline UACR was available for 16,843 (98.15%) participants: 9,067 (53.83%) with ≤15 mg/g, 2,577 (15.30%) with &gt;15 to &lt;30 mg/g, 4,030 (23.93%) with 30–300 mg/g, and 1,169 (6.94%) with &gt;300 mg/g. Measured as a continuous variable, UACR improved from baseline to 4.0 years with dapagliflozin, compared with placebo, across all UACR and eGFR categories (all P &lt; 0.0001). Sustained confirmed ≥1 category improvement in UACR was more common in dapagliflozin versus placebo (hazard ratio 1.45 [95% CI 1.35–1.56], P &lt; 0.0001). Cardiorenal outcome was reduced with dapagliflozin for subgroups of UACR ≥30 mg/g (P &lt; 0.0125, Pinteraction = 0.033), and the renal-specific outcome was reduced for all UACR subgroups (P &lt; 0.05, Pinteraction = 0.480).

CONCLUSIONS
In DECLARE-TIMI 58, dapagliflozin demonstrated a favorable effect on UACR and renal-specific outcome across baseline UACR categories, including patients with normal albumin excretion. The results suggest a role for SGLT2i also in the primary prevention of diabetic kidney disease.
Pedagogical conditions of civic education of senior high school students on the basis of national traditions
Authors: Gruzevich Tatiana , Miroshnichenko Valentina , Tushko Klavdiia , Volynets Nataliya , Sovva Sergey , Krivoruchko Irina 
Published: July 2021

The purpose of the article is to check the effectiveness of pedagogical conditions of civic education of senior high school students on the basis of national traditions. Various diagnostic methods were introduced, which made it possible to identify the effectiveness of applying the developed pedagogical conditions, to adjust the methodology for their further implementation. Attention was paid to comparing the results in the control group and the experimental one both on each criterion and on the array of criteria. The authors conclude that it is important to properly combine different research methods based on the research findings on checking the effectiveness of pedagogical conditions of civic education of senior high school students on the basis of national traditions. The significance of the article is that the criteria of the proposed pedagogical conditions in secondary schools will help to improve the process of civic education of senior high school students.
Leader Election in a Cluster using Zookeeper
Authors: Petrescu M. 
Published: July 2021

This paper presents an algorithm for flexible and fast leader election in distributed systems using Apache Zookeeper for configuration management.
The algorithm proposed in this paper is designed for applications that do not use symmetric nodes so they need a specialized election process or for applications that require a more flexible approach in the leader election process. The algorithm proposes a different approach as it allows assigning prioritizations for servers in the cluster that are candidates to become a leader. The algorithm is flexible as it takes into consideration during the leader election process of the different server settings and roles, network properties, communication latency or specific application requirements.
PENGATURAN PERLINDUNGAN HAK CIPTA PERMAINAN VIDEO
Authors: Sari Nusan Indah Permata , Kusuma Anak Agung Gede Agung Dharma 
Published: July 2021

Tujuan penulisan jurnal ilmiah ini adalah untuk mengetahui pengaturan permainan video dalam Undang-Undang Hak Cipta dan mengetahui bagaimana perlindungan hukum hak cipta terhadap pelanggaran permainan video. Tulisan ini menggunakan metode penelitian hukum normatif dengan menggunakan pendekatan perundang-undangan. Hasil dari penelitian ini menunjukkan bahwa terdapat kekaburan norma pada Undang-Undang Hak Cipta yaitu pada ketentuan pasal 40 ayat (1) huruf r “permainan video”. Kekaburan norma ini terlihat jelas karena tidak adanya penjelasan lebih lanjut terkait dengan pengertian permainan video serta pengklasifikasiannya. Selain itu terlihat jelas pula bahwa terdapat kekosongan norma terkait dengan sanksi bagi pelanggar hak moral pencipta yang tidak dilakukan tidak untuk kegiatan komersiil. Selanjutnya kesimpulan kedua bahwa permainan video merupakan salah satu objek dari suatu ciptaan yang dilindungi oleh Undang-Undang Hak Cipta yang perlindungannya berlaku selama 50 tahun sejak permainan video tersebut dipublikasikan. Berdasarkan ketentuan pasal 95 Undang-Undang Hak Cipta, pencipta atau pemegang hak cipta atau ahli waris dari pencipta permainan video dapat mengajukan tuntutan ganti rugi ke Pengadilan Niaga kepada pelaku pelanggaran hak ekonomi pencipta permainan video.

The purpose of this scientific journal is to know the rules of the video games in the Copyright law and to know how the copyright legal protection against video games violations. In this paper, the research method used is normative legal research which uses a statutory approach. The result of this journal are indicate there is a blurry norm in Article 40 paragraph letter r of Copyright law. The ambiguity of norm is cleary seen because there is no further explanation related to the understanding of video games and their classification and it is also cleary that there are void norm related to sanction for violators of the creator’s moral rights wich are not carried out not for commercial activities. Then, the second conclusions is that video games are one of the object of a creation that get protection from Copyright laws, the protection os valid for 50 years since the video games was published. Based on the Article 95 of Copyright law, the creator or copyright holder or the heirs of creator of video games can submit compensations claims to the Commersial Court to the perpretators of violations of the economic rights of the video games creator’s.
PERAN HAKIM SECARA FUNGSIONAL BERDASARKAN PASAL 44 KITAB UNDANG-UNDANG HUKUM PIDANA
Authors: Widya Widana I Nyoman Kari , Suartha I Dewa Made 
Published: July 2021

Studi ini bertujuan untuk menganalisis peran Hakim secara fungsional berdasarkan ketentuan Pasal 44 Kitab Undang-Undang Hukum Pidana (KUHP). Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian hukum normatif dengan menggunakan pendekatan peraturan perundang-undangan dan kasus. Adapun hasil penelitian menunjukkan bahwa peran hakim secara fungsional dalam menilai dan memutus perkara yang melibatkan orang yang cacat karena penyakit berdasarkan ketentuan Pasal 44 Kitab Undang-Undang Hukum Pidana (KUHP) dalam perkembangan penegakkan hukumnya saat ini telah dikesampingkan. Hal ini disebabkan masih lemahnya atau kurang jelasnya pengaturan Pasal 44 KUHP terkait peran hakim dalam menilai dan memutus perkara yang melibatkan pelaku tindak pidana yang jiwanya cacat dalam pertumbuhan atau karena penyakit, sehingga menimbulkan dualisme pandangan yang berbeda dari setiap sub sistem peradilan pidana (kepolisian, kejaksaan, peradilan).
This study aims to analyze the role of Judges functionally based on the provisions of Article 44 of the Criminal Code. The research method used in this study is a normative-law study method using a regulatory and case-rule approach. As for the conclusion of this scientific work, the role of a functional judge and dissolution involving a person who is malformed by article 44 of the criminal code in the current law enforcement development has been ruled out. This is due to the lack of or clarity of the penal code, article 44 of the criminal code relating to the role of judge and cutting a case involving perpetrators whose lives are impaired in growth or because of disease, leading to a different dualismne view from any subsystem of criminal justice (police, prosecutors, justice).
Migración venezolana reciente en la República Argentina: redes sociales e inserción laboral en Santa Rosa-Toay (La Pampa).
Authors: Linares María Dolores 
Published: July 2021

La República Bolivariana de Venezuela ha experimentado en la última década un cambio rotundo en su patrón migratorio, pasando de ser un país receptor de inmigrantes a un emisor masivo hacia destinos diversos. La República Argentina ha participado en la recepción de este flujo migratorio y se calcula que más de 120.000 migrantes venezolanos han arribado en los últimos tres años (DNM, Radicaciones 2016, 2017 y 2018). El objetivo de este artículo es describir y analizar las trayectorias laborales y las redes sociales de los y las migrantes recientes (2010-2019) en las ciudades de Santa Rosa y Toay, Provincia de la Pampa. Desde la perspectiva teórica de las redes sociales migratorias y a partir de un abordaje cualitativo basado en la realización de entrevistas en profundidad a migrantes venezolanos/as, se analizan las variables relacionadas con las trayectorias laborales y la utilización/constitución de redes sociales migratorias. Se discute las experiencias y percepciones sobre el quiebre en la trayectoria laboral, la informalidad y precariedad laboral y la formación y utilización tanto de redes migratorias virtuales como de aquellas basadas en apoyos personales.
SCIENTIFIC AND METHODOLOGICAL WORK AS A FORM OF MANAGEMENT OF THE DEVELOPMENT OF PROFESSIONAL COMPETENCE OF A TEACHER
Authors: PROTSENKO Іrina , BYKOVA Mariia 
Published: July 2021

On the basis of consideration of theoretical, methodological and scientific literature, the essence of the basic concepts of the research problem have been analyzed. It has been established that control is inherent only in complex integral systems. It is determined that every teacher, head of an educational institution, at one’s position in cooperation with one’s colleagues, must perform one’s own specific functions, while simultaneously guiding one’s activities towards achieving the overall goal of the system. It is indicated that the management of the development of teacher's professional competence, as a rule, is carried out at several levels: hierarchical management (arises in connection with an order, instruction, requirement, the formation of regimes and restrictions, which are part of the main documentation of the educational institution); parity management (provides for democratic, interested, equal participation for all in the life and activities of an educational institution, in the process of which there are no authority and subordinates, but there is a useful joint activity focused on application of personal interests and qualities in common work; parity interaction makes it possible to discover hidden abilities of a teacher, there is mutual learning) and latent management (it aims at application of a large amount of information and opportunities from the outside to stimulate the teacher's creative search, push him to independently invent an idea or solution).
It was found that scientific and methodological work in an educational institution is a holistic system based on the achievements of science and advanced pedagogical experience and on a specific analysis of the educational process, a system of interrelated actions and activities aimed at a comprehensive improvement of qualifications in the professional skills of each teacher and educator (including measures to manage professional self-education and self-education of teachers), to develop and increase the creative potential of the teaching staff, and ultimately to improve the educational process, to achieve the optimal level of education, upbringing and development of specific specialists.
MODELS OF THE LESSONS ON CRITICAL THINKING DEVELOPMENT: ANANLYSIS AND PECULIARITIES OF DESIGN
Authors: HUZAR OLENA , LIONENKO MARIIA 
Published: July 2021

The article deals with the models of the lessons of critical thinking and the peculiarities of their design. The attention is drawn to the fact that critical thinking is an important element of the numerous processes necessary for effective learning, which are formed and developed through a complex, systematic and system-defined application of certain strategies, models, methods and techniques. There is given a detailed description of the basic model of the lesson on critical thinking development, which consists of three stages (the introduction, the main part and the summary), has a certain logic of application and provides ways for combining certain methods / techniques. The attention is focused on the correct and full application of the cyclic model of training by D. Kolb while designing the lessons on critical thinking. It is suggested that a five-staged model of the training by R. Duron, B. Limbach and W. Waugh, which is based on the existing theory and advanced methods of cognitive development of children, should be used to apply as the basis for the lessons on critical thinking development. The application of various models of the lessons on critical thinking development makes it possible to make an educational process more diverse and interesting for students, and for teachers. After all, the critical thinking is formed gradually, it is the result of the daily hard work of the teacher and a student, from lesson to lesson, from year to year, which, in a public prospect, prepares children to conscious and responsible participation in social processes, teaches them to make reasonable decisions, effectively solve problem situations.