bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of the hyperiidean amphipod family Brachyscelidae Stephensen, 1923 (Crustacea: Amphipoda: Hyperiidea)
Authors: ZEIDLER WOLFGANG 
Published: August 2021

This is the first comprehensive taxonomic review of the family Brachyscelidae. The family is currently mono-generic following the review of Zeidler (2016). There are 17 nominal species referable to the genus Brachyscelus in the literature including two old references to species that most likely represent species of Brachyscelus. However, most are regarded junior synonyms of the two better known species B. crusculum Spence Bate, 1861 and B. globiceps (Claus, 1879). The taxonomic status of all nominal species was re-determined by the examination of extant type material or from the original literature reference if type material could not be found. In conclusion, five species of Brachyscelus are recognized as valid. Brachyscelus crusculum is the most common and widespread species and is most often recorded in the literature, but it is likely that some of these literature records are erroneous because other species have been confused with it in the past. The other species recognized are B. globiceps, B. macrocephalus Stephensen, 1925, B. rapacoides Stephensen, 1925 and B. rapax (Claus, 1871). Brachyscelus globiceps and B. macrocephalus are well established species and the validity of B. rapacoides was recently confirmed by Zeidler et al. (2018) but the validity of B. rapax is difficult to determine because type material could not be found and the original description by Claus (1871) and later figure (Claus 1887) are very inadequate. However, the species is tentatively recognized here based on several specimens which are most likely this species as according to Claus (1871, 1887). Brachyscelus is widely distributed in tropical and warm-temperate regions of the world’s oceans including the Mediterranean Sea. Species are preferentially associated with medusae and to a lesser extent with salps.
Long non-coding RNAs HERH-1 and HERH-4 facilitate cyclin A2 expression and accelerate cell cycle progression in advanced hepatocellular carcinoma
Authors: Liu Tao , Shi Qiao , Yang Lei , Wang Shusen , Song Hongli , Wang Zhenglu , Xu Xinnv , Liu Hongsheng , Zheng Hong , Shen Zhongyang 
Published: August 2021

Abstract
Background
The advanced hepatocellular carcinoma (HCC), such as the recurrent tumor after liver transplantation (LT), is an obstacle of HCC treatment. The aim of this study was to discover the underlying mechanism of HCC progression caused by non-coding RNAs (ncRNAs).

Methods
To this end, we investigated the selected patient cohort of matching primary and recurrent HCC after receiving LT. The recurrent tumors after LT were regarded as clinical models of the advanced HCC. Microarrays were used to profile lncRNA and mRNA expression in HCC recurrent and primary tissue samples. The mRNA profile characteristics were analyzed by bioinformatics. Two cell lines, HepG2 and QGY-7703, were used as HCC cell models. The protein-coding potential, length, and subcellular location of the interested lncRNAs were examined by bioinformatics, Northern blot, fluorescent in situ hybridization (FISH), and quantitative RT-PCR (qRT-PCR) assays. HCC cell proliferation was detected by CCK-8, doubling time and proliferation marker gene quantitation assays. DNA replication during the cell cycle was measured by EdU/PI staining and flow cytometry analyses. Promoter activity was measured using a luciferase reporter assay. Interactions between DNA, RNA, and protein were examined by immunoprecipitation and pull-down assays. The miRNA-target regulation was validated by a fluorescent reporter assay.

Results
Both lncRNA and mRNA profiles exhibited characteristic alterations in the recurrent tumor cells compared with the primary HCC. The mRNA profile in the HCC recurrent tissues, which served as model of advanced HCC, showed an aberrant cell cycle regulation. Two lncRNAs, the highly expressed lncRNA in recurrent HCC (HERH)-1 and HERH-4, were upregulated in the advanced HCC cells. HERH-1/4 enhanced proliferation and promoted DNA replication and G1-S transition during the cell cycle in HCC cells. HERH-1 interacted with the transcription factor CREB1. CREB1 enhanced cyclin A2 (CCNA2) transcription, depending on HERH-1-CREB1 interaction. HERH-4 acted as an miR-29b/c sponge to facilitate CCNA2 protein translation through a competing endogenous RNA (ceRNA) pathway.

Conclusions
The oncogenic lncRNA HERH-1/4 promoted CCNA2 expression at the transcriptional and post-transcriptional levels and accelerated cell cycle progression in HCC cells. The HERH-1-CREB1-CCNA2 and HERH-4-miR-29b/c-CCNA2 axes served as molecular stimuli for HCC advance.
Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma
Authors: Ma Xiao , Yang Su , Jiang Hesheng , Wang Yujie , Xiang Zhen 
Published: August 2021

Abstract
Background
Accumulative evidence shows that an organoid is a more practical and reliable tool in cancer biology research. This study aimed to identify and validate crucial genes involved in non-small cell lung cancer carcinogenesis and development using the transcriptomic analysis of tumor tissues and organoids.

Methods
Gene set enrichment analysis (GSEA) of tumor tissues, tumor organoids, and normal tissues was performed to reveal the similar and different mechanisms involved in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) carcinogenesis and progression. Differentially expressed gene analysis, prognostic analysis, and gene co-expression network analysis were further used to identify hub genes involved in LUAD and LUSC carcinogenesis and development. Finally, LUAD cell lines and organoids were used to validate these findings.

Results
GSEA analysis was performed to reveal the similar mechanisms involved in LUAD and LUSC carcinogenesis and development, such as P53 signaling pathway, base mismatch repair, DNA replication, cAMP signaling pathway and PPAR pathway. However, comparing with LUSC organoids, LUAD organoids showed downregulation of immune-related pathways, inflammation-related pathways, MAPK signaling pathways, and Rap1 signaling pathways, although these pathways were downregulated in LUAD and LUSC tissues by comparing with normal lung tissues. Further gene co-expression network analysis and prognostic analysis indicated CDK1, CCNB2, and CDC25A as the hub tumor-promoting genes in LUAD but not in LUSC, which were further validated in other datasets. Using LUAD cell lines and organoid models, CDK1 and CCNB2 knockdown were found to suppress LUAD proliferation. However, CDC25A knockdown did not inhibit LUAD cell line proliferation but could effectively suppress LUAD organoid growth, indicating that an organoid could be used as an effective tool to study cancer biology in LUAD.

Conclusions
The results revealed CDK1, CCNB2, and CDC25A as the hub genes involved in LUAD carcinogenesis and development, which could be used as the potential biomarkers and targets for LUAD.
Combined Custom Hedging: Optimal Design, Noninsurable Exposure, and Operational Risk Management
Authors: Guiotto Paolo , Roncoroni Andrea 
Published: August 2021

Optimal Design of Combined Contingent Claims: Theory and Applications.In “Combined Custom Hedging: Optimal Design, Noninsurable Exposure, and Operational Risk Management”, Paolo Guiotto and Andrea Roncoroni develop a normative framework for the optimal design, value assessment, and operations management integration of financial derivatives. Most business and operating revenues entail a mix of financially insurable and noninsurable risk. A risk-averse firm may face them by positioning in a pair of financial derivatives with optimal bespoke payoff functions; one claim is written on the insurable term, and the other claim is written on any observable index exhibiting correlation to the noninsurable term. On a theoretical ground, the authors 1) state the problem in a general setup and prove existence and uniqueness of the optimal pair of combined claims, 2) show that the optimal payoff functions satisfy a Fredholm integral equation, and 3) assess the incremental benefit the firm obtains by switching from the optimal single-claim custom hedge to the optimal combined custom hedge they propose. On an experimental ground, they show that 1) the optimal combined custom hedge would be empirically relevant for a highly risk-averse firm facing a market shock shown during the first period of the COVID-19 pandemic in 2020, 2) integration with the optimal procurement in a generalized newsvendor model leads to a significant improvement in both risk and return, and: 3) this gain can be traded off for a substantial enhancement in operational flexibility.
Structure and tree species composition of forest fringe of a forest fragment in an oil palm plantation at Suai, Sarawak, Malaysian Borneo
Authors: Jana Claudia Lennya , JUSOH ISMAIL 
Published: August 2021

Abstract. Jana CL, Jusoh I. 2021. Structure and Tree Species Composition of Forest Fringe of A Forest Fragment in an Oil Palm Plantation at Suai, Sarawak, Malaysian Borne. Biodiversitas 22: 3013-3019. Forest fragments in oil palm plantations are remnants of the original forest tract with various sizes and shapes after clearing forested lands for crops and roads. Fragmented forests usually created forest fringe or edge habitats that differ in light intensity, temperature, humidity, heavy rainfall, and strong winds from its core. The study was aimed to determine the structure and tree species composition of the forest fringe of a fragmented forest in an oil palm plantation Suai, Sarawak. This study established a total of 24 sampling plots within the forest fringe. Tree enumeration and species identification were conducted in all sampling plots to all trees with a diameter at breast height 5 cm and higher. A total of 59 families comprised of 274 species and 948 trees individuals were recorded. The aboveground biomass stand at 260 Mg ha?¹. Species Elateriospermum tapos was predominant, and family Dipterocarpaceace dominated the forest fringe. Based on the calculated indices, species diversity and richness were considered high, while the dispersion of individual trees was random but unevenly distributed. Natural regeneration in the forest fringe is sustainable. The forest structure and species composition are intact, and without significant disturbance, the whole forest fragment is self-sustain.
Orthorexia nervosa and disordered eating attitudes among Lebanese adults: Assessing psychometric proprieties of the ORTO-R in a population-based sample
Authors: Hallit Souheil , Brytek-Matera Anna , Obeid Sahar 
Published: August 2021

Background
Previous research demonstrated a relationship between ON and disordered eating symptoms (eating concern, restraint, cognitive preoccupations about body shape and weight) and disordered eating attitudes (DEA). Since screening for orthorexia nervosa is now part of clinical practice, the measurement instruments to be used must be clinically significant, reliable, valid and sensitive to our target population. The main objective of the present study was to confirm the factor structure of the Arabic version of the ORTO-R using a first sample of Lebanese adults and confirm those results on another sample. The secondary objective was to assess sex differences in terms of ON and DEA, as well as to examine whether symptoms of ON were related to DEA in Lebanese adults.

Methods
A total of 783 Lebanese adults was selected to participate in this cross-sectional study (January-May 2018) using a proportionate random sample from all Lebanese governorates.

Results
The mean age of the total sample was 27.78 ± 11.60 years (Min. 18 –Max. 84) (33.5% females) and their mean BMI was 24.36 ± 5.31 kg/m2. All items of the ORTO-R were extracted during the factor analysis and yielded a two-factor solution with Eigenvalues > 1 (variance explained  =  50.07%; KMO = 0.570; Bartlett’s sphericity test p<0.001; αCronbach = 0.755). This factor structure was confirmed by a confirmatory factor analysis; the Maximum Likelihood Chi-Square  =  26.894 and Degrees of Freedom  =  8, which gave a χ2/df  =  3.36. The Tucker Lewis Index (TLI) value was 0.914, whereas the standardized root mean square residual (SRMR) value was 0.032. The root mean square error of approximation (RMSEA) value was 0.077 [95% CI 0.046–0.111] (pclose = 0.07) and comparative fit index (CFI) value was 0.967 respectively, indicating a good fit of the model. There was also no measurement invariance between genders. Female gender was significantly associated with lower ORTO-R scores (more orthorexia nervosa) compared to males (B = -0.65; p = 0.026, 95% CI -1.22- -0.08; ɳ2 = 0.006). However, no significant difference was found between genders in terms of EAT-26 scores (B = 0.23; p = 0.813, 95% CI -1.66–2.12; ɳ2 = 0.0001). Higher ORTO-R scores (lower/ less pathological ON tendencies and behaviors) were significantly related to higher EAT-26 total scores (higher levels of DEA) as well as higher dieting, bulimia and oral control scores in both females (from a weak to a moderate positive correlation) and males (a weak positive correlation).

Conclusion
This cross-sectional population-based study confirmed the factor structure of the Arabic version of the ORTO-R, demonstrated an association between ON and DEA and revealed more ON among females compared to males.
A quantitative analysis of food insecurity and other barriers associated with ART nonadherence among women in rural communities of Eswatini
Authors: Becker Nozipho , Poudel Krishna C. , Cordeiro Lorraine S. , Sayer Aline G. , Sibiya Thokozile E. , Sibeko Lindiwe N. 
Published: August 2021

Background
Eswatini has the highest global prevalence of HIV despite decades of universal access to free antiretroviral therapy (ART). We conducted a mixed methods study to investigate barriers to ART adherence among women living with HIV (WLHIV) in rural communities of Eswatini. Qualitative findings were reported in our previous publication. This subsequent paper expands on our qualitative analysis to examine the magnitude to which identified barriers impacted ART adherence among WLHIV in the same communities.

Methods
We used an exploratory sequential design to collect data from WLHIV (n = 166) in rural Eswatini. Quantitative data were collected using interviewer-administered survey questionnaires between October and November 2017. ART adherence was measured using the CASE Adherence Index, with scores less than 10 indicating nonadherence. Log-binomial regression models were used to examine the extent to which critical barriers affected ART adherence among study participants.

Results
A majority of the women in our study (56%) were nonadherent to ART. Of the barriers identified in our prior qualitative analysis, only eight were found to be significantly associated with ART nonadherence in our quantitative analysis. These include, with adjusted risk ratios (ARR) and 95% confidence intervals (95% CI): household food insecurity (ARR: 3.16, 95% CI: 1.33–7.52), maltreatment by clinic staff (ARR: 2.67, 95% CI: 1.94–3.66), forgetfulness (ARR: 1.80, 95% CI: 1.41–2.31), stress (ARR: 1.47, 95% CI: 1.14–1.88), gossip (ARR: 1.57, 95% CI: 1.21–2.04), mode of transport (ARR: 0.59, 95% CI: 0.44–0.79), age (ARR: 0.98, 95% CI: 0.97–0.99), and lack of community support (ARR: 0.55, 95% CI: 0.35–0.85).

Conclusions
Among numerous barriers identified in our study, food insecurity was found to be a significant contributor toward ART nonadherence among women living with HIV in rural Eswatini. Future strategies aimed at improving ART adherence in Eswatini should include programs which provide food and nutrition support for people living with HIV, particularly rural women living in poverty.
The Platelet-to-lymphocyte ratio, PELOD-2 score, and mortality rate in pediatric sepsis
Authors: Rampengan Novie Homenta , Joey Gregory , Kurniawan Ferry , Manoppo Jeanette I. Ch. , Runtunuwu Ari Lukas 
Published: August 2021

Background Sepsis is life-threatening organ dysfunction caused by a regulated immune response to infection. Sepsis remains the most common cause of death in infants and children worldwide. The Pediatric Logistic Organ Dysfunction (PELOD-2) score, one of the most widely used scoring systems in pediatric sepsis patients, has been shown to be accurate in predicting mortality. The platelet-to-lymphocyte ratio (PLR) is a new clinical indicator of inflammation in a variety of diseases including sepsis.
Objective To investigate the relationship between PLR, PELOD-2 score, and clinical outcomes in pediatric patients with sepsis.
Methods This retrospective cohort study was conducted in the Pediatric Intensive Care Unit (PICU), Prof R.D. Kandou Hospital, Manado, North Sulawesi, from February to August 2020. Subjects’ PELOD-2 score and PLR were recorded once within the first 24 hours of PICU admission. We analyzed patients’ PELOD-2 score, PLR, and mortality rate, with 95% confidence interval (CI) for each value.
Results Of 96 children with sepsis admitted to the PICU during the study period, 87 patients (46 boys; 52.9%) met the inclusion criteria. In total, 50 (57.47%) patients were non-survivors. Mean PLR values among survivors [77.54 (SD 50.08)] was significantly lower compared to the values among non-survivors [157.13 (SD 67.38)]; as well as the PELOD-2 score in the survivors group [12 (SD 1.32)] was significantly lower than its value in the non-survivors [14.65 (SD 2.09)]. Spearman’s analysis showed a moderately positive correlation between PLR and PELOD-2 score (r=0.444; 95%CI 0.44 to 1; P<0.01). Biserial point correlation analysis revealed a significant association between PLR and mortality rate (rpb=0.566; P<0.0001),with elevated PLR related to an increased risk of mortality.
Conclusion There are positive correlations between PLR, PELOD-2 score, and mortality rate in pediatric patients with sepsis. Higher PLR and PELOD-2 score are associated with higher mortality.
Cylindrical intensive vs. double surface LED phototherapy for neonatal hyperbilirubinemia
Authors: Sulviatni Rini , Syuhada Khonsa Hartsu , Krissanti Hanny , Purnama Denny 
Published: August 2021

Background High bilirubin levels may lead to complications such as bilirubin encephalopathy or even death. Therefore, neonatal hyperbilirubinemia patients require appropriate treatment in the form of phototherapy or exchange transfusion. With the advancement of technology, various types of phototherapy, such as the cylindrical intensive phototherapy (bilisphere) and double LED, are now available.
Objective To compare cylindrical intensive phototherapy to double surface LED phototherapy in neonatal hyperbilirubinemia.
Methods This cohort study was conducted in neonates with hyperbilirubinemia at at Syamsudin SH Hospital, Sukabumi, West Java, who were treated with either cylindrical intensive phototherapy or double surface LED phototherapy. The variables observed were subjects’ characteristics, bilirubin levels pre- and post-therapy, duration of phototherapy, length of stay, and total treatment cost. The data were analyzed using univariate and bivariate analyses.
Results Of 47 neonates, the mean bilirubin levels were 19.36 mg/dL pre-therapy and 12.26 mg/dL post-therapy. Subjects’ overall mean duration of phototherapy was 24 hours, mean length of stay was 1 day, and mean cost of treatment was IDR 813,175. There was no significant difference in the bilirubin decrease between the cylindrical intensive phototherapy and double LED groups. However, there were significant differences between the cylindrical intensive phototherapy and double LED groups in duration of phototherapy (10.75 vs. 75.17 hours, respectively (P<0.000), mean length of stay (1 vs. 3.13 days, respectively (P<0.000), and total cost of treatment (IDR 598,918 vs. IDR 1,036,747, respectively P<0.000).
Conclusion While the decrease in bilirubin was not significantly different in neonatal hyperbilirubinemia patients who underwent cylindrical intensive phototherapy compared to double LED therapy, cylindrical intensive phototherapy relates to significant shorter phototherapy duration, length of stay, and total treatment cost. Hence, cylindrical intensive phototherapy phototherapy is considered to be more time-efficient and cost-efficient than double LED phototherapy.
Perfil del egresado de la Licenciatura en Flauta de la Universidad Nacional de Cuyo y su inserción laboral:
Authors: Ganem Ábrego Juan Pablo 
Published: August 2021

El presente artículo analiza el perfil del egresado de la Licenciatura en Flauta de la UNCuyo y su inserción laboral. Se focaliza en la relación entre las herramientas brindadas en los planes de estudio y las exigencias de un puesto de trabajo con especificidad en el campo del título obtenido, observada desde el punto de vista de un grupo de egresados y estudiantes avanzados de la carrera. Se utilizó una metodología mixta, articulando datos cuantitativos obtenidos a través de una encuesta de preguntas cerradas, con datos cualitativos construidos a partir de entrevistas. Sumado a un relevamiento de puestos de trabajo afines, que permitió tipificar la realidad laboral actual del flautista profesional en la Argentina, se describieron las dificultades que se les presentan a los egresados para lograr una carrera deseable y sustentable en el terreno de la performance musical. Por ello, es que se llegó a la conclusión de que, en un medio caracterizado por la escasez de puestos de trabajo específicos, los egresados deben valerse de herramientas que trascienden a las ofrecidas en una formación de grado universitario.
Cambios en la práctica laboral de los profesionales de enfermería por la pandemia SARS-CoV-2/COVID-19 en una ciudad de Colombia
Authors: Orgulloso Bautista Claudia Alejandra , Beleño Pinedo Leisly , Méndez Vergara Rosa Isela 
Published: August 2021

Objetivo: Determinar los cambios en las prácticas laborales del profesional de enfermería a causa de la pandemia SARS-CoV-2/COVID-19.
Materiales y Métodos: Estudio de corte transversal en una población de profesionales de enfermería que se encontraban laborando durante la pandemia en la ciudad de Cartagena, con una muestra total de 115 individuos a través de un muestreo de bola de nieve, a los que se les aplicó una encuesta de manera virtual, se realizó un análisis estadístico descriptivo.
Resultados: La muestra estuvo conformada en su mayoría por mujeres con un 82,6%, en edades entre 30 a 40 años con un 42,6% y el 72,2% tenían formación de pregrado. El 92,2% de los profesionales de enfermería manifiestan que con la pandemia del SARS-CoV-2/COVID-19 se han presentado grandes cambios en su práctica laboral con el aumento de más actividades o tareas de las que se realizaban anteriormente, con la aplicación de nuevas estrategias en la atención y cuidados de los pacientes, con una alta percepción de riesgo en su lugar de trabajo para el contagio y dificultades económicas a nivel laboral por la pandemia y no consideran cambiar de perfil laboral u ocupacional por esta situación que está pasando.
Conclusiones: la crisis sanitaria mundial actual, expone la necesidad que han tenido los profesionales de adaptar nuevas prácticas laborales y competencias a las nuevas demandas del mercado laboral.