bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atividades biológicas da espécie spilanthes acmella: uma revisão
Authors: Dias Rafael Silva , Brasil Davi do Socorro Barros , Martelli Marlice Cruz 
Published: November 2021

A proposta do trabalho é apresentar uma revisão bibliográfica sobre atividades biológicas em plantas da espécie Spilanthes acmella (L.). A pesquisa foi realizada no período de setembro a novembro de 2019 e consistiu em uma busca na base de dados do SciFinder, considerando, os artigos publicados no período entre janeiro de 1959 e janeiro de 2021 e utilizando as palavras-chave: Acmella oleracea, Spilanthes acmella, antioxidante, antipirético e anti-inflamatório. Por meio desse processo resultou em 32 artigos encontrados endossando as atividades biológicas que são atribuídas à espécie Spilanthes acmella (L.), como as atividades inseticida e anti-inflamatória. Muitas atividades que eram atribuídas à planta Spilanthes acmella puderam ser comprovadas, assim como as substâncias biologicamente ativas e seus mecanismos de ação, em especial a atividade inseticida, que demonstrou grande potencial contra várias espécies de invertebrados.
Expondo os benefícios dos microrganismos aos seres humanos para alunos de Ensino Médio em São Luís-MA
Authors: Vila Nova Beatriz Gomes , Silva Lucas dos Santos , Sabóia Rafaella Santos , Alves Lully Gabrielly Silva , Gomes Paulo Dyago Borges , Galvão Lívia Câmara de Carvalho , Sousa Eduardo Martins de 
Published: November 2021

Tratar dos microrganismos e os relacionar com o seu extenso leque de benefícios, no âmbito escolar, é de suma importância na perspectiva de deixar-se de lado o conceito de que os mesmos são apenas nocivos à saúde humana. O objetivo do projeto foi averiguar o que estudantes do ensino médio compreendem ou acreditam compreender sobre os microrganismos, e a partir disso, promover conhecimento e desfazer os conceitos distorcidos, assegurando que os microrganismos também são passíveis de benefícios. O projeto foi realizado no Colégio Marista Araçagy localizado no município de São José de Ribamar, no Maranhão, com alunos do 3º ano do ensino médio. Previamente os alunos foram pré-avaliados para que pudéssemos estimar seus conhecimentos acerca dos microrganismos e quão benéficos são. Logo em seguida o tema foi abordado com o auxílio de slides, onde definiu-se conceitos, benefícios e exemplos foram relatados. Seguidamente, aplicou-se novamente um questionário com o intuito de mensurarmos o rendimento e aprendizado após os sujeitarmos à ação proposta. Após análise do questionário, verificou-se que dos 31 alunos que participaram, 39% não tinham conhecimento sobre a temática, enquanto 61% disseram já ter tido contato com o tema e 10% dos estudantes afirmaram que todas as bactérias são patogênicas. Só foi possível evidenciarmos um cenário animador após avaliarmos as respostas do segundo questionário. Contudo, favorecer conhecimento prévio sobre os microrganismos e seus benefícios é sem dúvida primordial na construção do saber acerca do que é verídico.
The Theology Of The Incarnation: A Paradigm For A Theology Of Contextual In The Era Of The Third Millennium
Authors: Ranto Ranto 
Published: November 2021

Why is it necessary to learn the Theology of the Incarnation, it is not separated from some of the advantages of basic and very critical of the approach of this theology. First, the Theology of the Incarnation to take the role as a theology of contextual provided the Bible itself, and that God has taken this pattern in the states themselves, and his word to man. This is the pattern and the case of biblical theology and contextual theology in the context of health. Next, as an example the case of theology is contextual, the role of the incarnation embodies well the demands of the two mandates the basis of theology is contextual. In this case, God and His Word are eternal it is final, eternal, and unchangeable in the encounter, and ‘incarnation” in humanity and human culture. While at the same time, there is no doubt that it is relevant and following the bible.
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study
Authors: Cui Zhiyong , Feng Hui , He Baichuan , He Jinyao , Tian Yun 
Published: November 2021

BackgroundThis study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).MethodsWe performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-wide association study (GWAS) data. We applied the MR Steiger filtering method and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to check for and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. The associations were estimated with the inverse variance weighted (IVW), MR-Egger, weighted median and MR Robust Adjusted Profile Score (MR.RAPS) methods.ResultsOur study found that genetically increased isoleucine (Ile) [IVW: effect = 0.1601, 95% confidence interval (CI) = 0.0604 ~ 0.2597, p = 0.0016] and valine (Val) levels (IVW: effect = 0.0953, 95% CI = 0.0251 ~ 0.1655, p = 0.0078) were positively associated with total body BMD (TB-BMD). The results also revealed that genetically increased tyrosine (Tyr) levels were negatively associated with TB-BMD (IVW: effect = -0.1091, 95% CI = -0.1863 ~ -0.0320, p = 0.0055).ConclusionsIn this study, associations between serum AA levels and BMD were established. These findings underscore the important role that serum AAs play in the development of osteoporosis and provide evidence that osteoporosis can be prevented and treated by the intake of certain AAs.
Prognostic Influence of Residual Tumor-Infiltrating Lymphocyte Subtype After Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Authors: da Silva Jesse Lopes , de Albuquerque Lucas Zanetti , Rodrigues Fabiana Resende , de Mesquita Guilherme Gomes , Fernandes Priscila Valverde , Thuler Luiz Claudio Santos , de Melo Andreia Cristina 
Published: November 2021

ObjectiveThis study aimed to examine the prevalence and prognostic role of tumor microenvironment (TME) in triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NACT) through immunohistochemical characterization.MethodsThe internal database of the Brazilian National Cancer Institute for women diagnosed with TNBC who underwent NACT and thereafter curative surgery between January 2010 and December 2014 was queried out. Core biopsy specimens and tissue microarrays containing surgical samples of TNBC from 171 and 134 women, respectively, were assessed by immunohistochemistry for CD3, CD4, CD8, CD14, CD56, CD68, CD117, FOXP3, PD-1, PD-L1, and PD-L2. Immune cell profiles were analyzed and correlated with response and survival.ResultsMean age was 50.5 years, and most cases were clinical stage III [143 cases (83.6%)]. According to the multivariate analysis, only Ki67 and clinical stage significantly influenced the pattern of response to systemic treatment (p = 0.019 and p = 0.033, respectively). None of the pre-NACT IHC markers showed a significant association with event-free survival (EFS) or overall survival (OS). As for post-NACT markers, patients with high CD14 had significantly shorter EFS (p = 0.015), while patients with high CD3 (p = 0.025), CD4 (p = 0.025), CD8 (p = 0.030), CD14 (p = 0.015), FOXP3 (p = 0.005), high CD4/FOXP3 (p = 0.034), and CD8/FOXP3 (p = 0.008) showed longer EFS. Only high post-NACT CD4 showed significantly influenced OS (p = 0.038).ConclusionThe present study demonstrated that the post-NACT TIL subtype can be a determining factor in the prognosis of patients with TNBC.
Geometric and Dosimetric Evaluation of Deep Learning-Based Automatic Delineation on CBCT-Synthesized CT and Planning CT for Breast Cancer Adaptive Radiotherapy: A Multi-Institutional Study
Authors: Dai Zhenhui , Zhang Yiwen , Zhu Lin , Tan Junwen , Yang Geng , Zhang Bailin , Cai Chunya , Jin Huaizhi , Meng Haoyu , Tan Xiang , Jian Wanwei , Yang Wei , Wang Xuetao 
Published: November 2021

PurposeWe developed a deep learning model to achieve automatic multitarget delineation on planning CT (pCT) and synthetic CT (sCT) images generated from cone-beam CT (CBCT) images. The geometric and dosimetric impact of the model was evaluated for breast cancer adaptive radiation therapy.MethodsWe retrospectively analyzed 1,127 patients treated with radiotherapy after breast-conserving surgery from two medical institutions. The CBCT images for patient setup acquired utilizing breath-hold guided by optical surface monitoring system were used to generate sCT with a generative adversarial network. Organs at risk (OARs), clinical target volume (CTV), and tumor bed (TB) were delineated automatically with a 3D U-Net model on pCT and sCT images. The geometric accuracy of the model was evaluated with metrics, including Dice similarity coefficient (DSC) and 95% Hausdorff distance (HD95). Dosimetric evaluation was performed by quick dose recalculation on sCT images relying on gamma analysis and dose-volume histogram (DVH) parameters. The relationship between ΔD95, ΔV95 and DSC-CTV was assessed to quantify the clinical impact of the geometric changes of CTV.ResultsThe ranges of DSC and HD95 were 0.73–0.97 and 2.22–9.36 mm for pCT, 0.63–0.95 and 2.30–19.57 mm for sCT from institution A, 0.70–0.97 and 2.10–11.43 mm for pCT from institution B, respectively. The quality of sCT was excellent with an average mean absolute error (MAE) of 71.58 ± 8.78 HU. The mean gamma pass rate (3%/3 mm criterion) was 91.46 ± 4.63%. DSC-CTV down to 0.65 accounted for a variation of more than 6% of V95 and 3 Gy of D95. DSC-CTV up to 0.80 accounted for a variation of less than 4% of V95 and 2 Gy of D95. The mean ΔD90/ΔD95 of CTV and TB were less than 2Gy/4Gy, 4Gy/5Gy for all the patients. The cardiac dose difference in left breast cancer cases was larger than that in right breast cancer cases.ConclusionsThe accurate multitarget delineation is achievable on pCT and sCT via deep learning. The results show that dose distribution needs to be considered to evaluate the clinical impact of geometric variations during breast cancer radiotherapy.
Development and Validation of a Radiomics Nomogram for Differentiating Pulmonary Cryptococcosis and Lung Adenocarcinoma in Solitary Pulmonary Solid Nodule
Authors: Zhao Jiabi , Sun Lin , Sun Ke , Wang Tingting , Wang Bin , Yang Yang , Wu Chunyan , Sun Xiwen 
Published: November 2021

ObjectiveTo establish a CT-based radiomics nomogram model for classifying pulmonary cryptococcosis (PC) and lung adenocarcinoma (LAC) in patients with a solitary pulmonary solid nodule (SPSN) and assess its differentiation ability.Materials and MethodsA total of 213 patients with PC and 213 cases of LAC (matched based on age and gender) were recruited into this retrospective research with their clinical characteristics and radiological features. High-dimensional radiomics features were acquired from each mask delineated by radiologists manually. We adopted the max-relevance and min-redundancy (mRMR) approach to filter the redundant features and retained the relevant features at first. Then, we used the least absolute shrinkage and operator (LASSO) algorithms as an analysis tool to calculate the coefficients of features and remove the low-weight features. After multivariable logistic regression analysis, a radiomics nomogram model was constructed with clinical characteristics, radiological signs, and radiomics score. We calculated the performance assessment parameters, such as sensitivity, specificity, accuracy, negative predictive value (NPV), and positive predictive value (PPV), in various models. The receiver operating characteristic (ROC) curve analysis and the decision curve analysis (DCA) were drawn to visualize the diagnostic ability and the clinical benefit.ResultsWe extracted 1,130 radiomics features from each CT image. The 24 most significant radiomics features in distinguishing PC and LAC were retained, and the radiomics signature was constructed through a three-step feature selection process. Three factors—maximum diameter, lobulation, and pleural retraction—were still statistically significant in multivariate analysis and incorporated into a combined model with radiomics signature to develop the predictive nomogram, which showed excellent classification ability. The area under curve (AUC) yielded 0.91 (sensitivity, 80%; specificity, 83%; accuracy, 82%; NPV, 80%; PPV, 83%) and 0.89 (sensitivity, 81%; specificity, 83%; accuracy, 82%; NPV, 81%; PPV, 82%) in training and test cohorts, respectively. The net reclassification indexes (NRIs) were greater than zero (p &lt; 0.05). The Delong test showed a significant difference (p &lt; 0.0001) between the AUCs from the clinical model and the nomogram.ConclusionsThe radiomics technology can preoperatively differentiate PC and lung adenocarcinoma. The nomogram-integrated CT findings and radiomics feature can provide more clinical benefits in solitary pulmonary solid nodule diagnosis.
Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
Authors: Wei Qi , Yan Yu-Jing , Wu Ge-Ge , Ye Xi-Rong , Jiang Fan , Liu Jie , Wang Gang , Wang Yi , Wang Yu , Pan Zhi-Ping , Hu Jin-Hua , Song Juan , Dietrich Christoph F. , Cui Xin-Wu 
Published: November 2021

ObjectiveThis study aimed to explore the value of elasticity score (ES) and strain ratio (SR) combined with conventional ultrasound in distinguishing benign and malignant breast masses and reducing biopsy of BI-RADS (Breast Imaging Reporting and Data System) 4a lesions.MethodsThis prospective, multicenter study included 910 patients from nine different hospitals. The acquisition and analysis of conventional ultrasound and strain elastography (SE) were obtained by radiologists with more than 5 years of experience in breast ultrasound imaging. The diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under curve (AUC) of conventional ultrasound alone and combined tests with ES and/or SR were calculated and compared.ResultsThe optimal cutoff value of SR for differentiating benign from malignant masses was 2.27, with a sensitivity of 60.2% and a specificity of 84.8%. When combined with ES and SR, the AUC of the new BI-RADS classification increased from 0.733 to 0.824 (p &lt; 0.001); the specificity increased from 48.1% to 68.5% (p &lt; 0.001) without a decrease in the sensitivity (98.5% vs. 96.4%, p = 0.065); and the PPV increased from 52.2% to 63.7% (p &lt; 0.001) without a loss in the NPV (98.2% vs. 97.1%, p = 0.327). All three combinations of conventional ultrasound, ES, and SR could reduce the biopsy rate of category 4a lesions without reducing the malignant rate of biopsy (from 100% to 68.3%, 34.9%, and 50.4%, respectively, all p &lt; 0.001).ConclusionsSE can be used as a useful and non-invasive additional method to improve the diagnostic performance of conventional ultrasound by increasing AUC and specificity and reducing the unnecessary biopsy of BI-RADS 4a lesions.
Когнітивна модель оптимізації продовольчої політики держави у контексті боротьби з цукровим діабетом
Authors: Golub V.V.  , Chumak I.V.  
Published: November 2021

У статті проаналізовано публічну політику в сфері продовольчої безпеки як забезпечення для громадян не лише фізичної та економічної, але й когнітивної доступності до необхідних для здоров’я продуктів харчування та оптимізації харових стереотипів населення. Розглянуто продовольчу політику як двосторонній процес формування, з одного боку, оптимального асортименту харчових ресурсів на теренах країни та конструктивних харчових уявлень та настанов громадян щодо їх використання. Концептуалізовано поняття когнітивної доступності продовольства та виокремлено когнітивні викривлення і бар’єри, які деформуючи харчову поведінку населення, істотною мірою спряють поширенню цукрового діабету. Обґрунтовано, що зростання захворюваності на цукровий діабет є одним із найважливіших індикаторів, який вказує на прорахунки в сфері політики продовольчої безпеки. Запропоновано політичні стратегії корекції та розвитку харчової ментальності громадян у контексті реалізації державної програми боротьби з діабетом.
Формування та реалізація державної політики у цифровізації сектору національної системи охорони здоров’я за напрямком орфанні захворювання
Authors: Zhyvylo I.O.  
Published: November 2021

У кожному суспільстві є люди, які страждають на захворювання, що мають важкий, хронічний та прогресуючий перебіг, при цьому вони потребують життєвого і, як правило, дороговартісного лікування. Громадяни, які страждають на рідкісні (орфанні) захворювання, належать до особливо вразливої категорії людей, оскільки їх лікування довічне та життєво необхідне.
Створення правових, економічних та управлінських механізмів реалізації конституційних прав населення України які страждають на рідкісні (орфанні) захворювання, збереження та зміцнення їх здоров’я, продовження періоду активного довголіття і тривалості їх життя є одним з головних завдань під час формування та реалізації державної політики у цифровізації сектору національної системи охорони здоров’я.
За цих умов, Міністерствами цифрової трансформації та охорони здоров’я України доволі суттєво акцентується увага на забезпеченні прозорості фінансування системи охорони здоров’я; депаперизація та здійсненні поступового переходу до електронного обліку (е-рецепт, е-направлення, е-картка); відбувається розвиток нових електронних сервісів для пацієнтів та впроваджується доступ до медичних даних, нових можливостей для бізнесу в медичній сфері.
Зокрема, однією з стратегічних цілей є розвиток eHealth та її компонентів, телемедицини, а також створення онлайн-платформи супроводу міжнародних програм з охорони здоров’я, медичної та фармацевтичної освіти й науки в Україні. В подальшому, з розвитком всих складових (підсистем) eHealth громадяни, які страждають на рідкісні (орфанні) захворювання, отримають більш ефективний, якісний та своєчасний доступ до специфічної та високовартісної терапії, а лікарі отримають актуальні епідеміологічні дані про кількість громадян та поширеність рідкісних (орфанних) захворювань. Одним із підтверджень цього є те, що кількість технологій, що застосовуються в системі охорони здоров’я, впродовж останніх років стрімко зростає.
Однак варто зазначити, що рішення про впровадження нових цифрових медичних послуг на різних рівнях системи охорони здоров’я в ідеалі повинні ґрунтуватися на фактичних даних про їх ефективність з урахуванням цілей системи охорони здоров’я.
PERJANJIAN TERAPEUTIK SEBAGAI DASAR BAGI DOKTER DALAM MEAKUKAN PENANGANAN MEDIS
Authors: Alwy Sabir , Afdhal Afdhal 
Published: November 2021

AbstractThis research aims to determine the relationship between doctor and patient in a therapeutic agreement, as provided for in Informed Consent and the law of medical practice for doctors and patients understand the obligations and responsibilities as well as provide insights for health professionals, especially physicians about the importance of treaties in creating therapeutic medical services appropriate to the patient.The research was conducted at two hospitals in the city of Makassar is Wahidin Sudirohusodo Hospitals and Hospitals Grestelina. Primary data collection instruments and interviews conducted with the data sender done with literature study and data collection at two institutions. Data were analyzed qualitatively.The results showed that the Therapeutic relationship that occurs between doctor and patient is currently well underway with the hospital where doctors and Grestelina Wahidin Sudirohusodo been clearly understood to provide information needed by patients from both phases of history, diagnosis/ so that everything recorded in prognosis medical records. The patient could complain of illness, but patients tend to be resigned to that advice from doctors is not done. Doctors and hospitals Wahidin Sudirohusodo Grestelina has done its responsibility in caring for patients with always do a routine for inpatients and how to be polite and respect the limits of its competence by following per under the oath that doctors say. Patients have appreciated doter with trying to provide honest information in which the function of creating belief between doctor and patient. Sudirohusodo Wahidin hospital doctors and medical services Grestelina have done in the form of counseling to the patient in choosing the appropriate medication and treatment conditions quickly for emergency room patients are by the SOP (Standard Operating Procedure). SOP (Standard Operating Procedure also regulates every doctor who wants to practice in the hospital, and Grestelina Wahidin Sudirohusodo must have the STR (letter of registration) and SIP (Permit Practice) through the provisions made by the Institute COUNCIL (Physician Discipline Committee) and the Organization of Ethics.
PENGAWASAN OMBUDSMAN TERHADAP PENYELENGGARAAN PELAYANAN PUBLIK PADA MASA PANDEMI CORONA VIRUS DISEASE 2019 (COVID-19)
Authors: Akim Inggit 
Published: November 2021

ABSTRACTSupervise the government as the provider of public services to carry out their duties and authorities under applicable regulations. Large-Scale Social Restrictions are restrictions on certain activities in an area suspected of being infected with Corona Virus Disease 2019 (COVID-19), which causes the quality of public services to be disrupted. The Ombudsman has the task of supervising the implementation of shared services organized by state or government officials and private or individual bodies assigned the task of providing services according to minimum service standards as a benchmark for service delivery and assessing the quality of services to the community. The research method used is normative juridical research with a conceptual approach (Statute Approach).The results of this study are large-scale social restriction policies through the Mayor of Tarakan Regulation Number 17 of 2020, restrictions on activities outside the house such as the implementation of learning at schools and/or other educational institutions, Work From Home (WFH), religious movements in houses of worship, activities in public places, social and cultural activities and Mandatory rapid tests for those using Sea and Air transportation modes, and providing social assistance to communities affected by COVID-19. Ombudsman's supervision of public services during the COVID-19 pandemic in Tarakan City, namely by conducting coordination and control and cooperation with state and private officials as well as community or individual organizations, opening an Online Complaint Post for COVID-19 Affected Persons. Also, conduct unannounced checks to improve public services in the City of Tarakan. Based on the supervision, the receipt of reports on suspicion of maladministration and the Ombudsman's investigation results are subject to examination. Suppose it is proven that it has committed maladministration in public services, the Ombudsman of the Republic of Indonesia can take corrective action and provide recommendations/suggestions to state administrators to improve the quality of public services. Keywords: Surveillance; Ombudsman; Public Service; COVID-19 Pandemic