bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk and outcomes of diabetes in patients with epilepsy
Authors: Li Chun-Cheng , Chang Chuen-Chau , Cherng Yih-Giun , Lin Chao-Shun , Yeh Chun-Chieh , Chang Yi-Cheng , Hu Chaur-Jong , Shih Chun-Chuan , Chen Ta-Liang , Liao Chien-Chang 
Published: September 2021

AbstractThe risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the research data of National Health Insurance in Taiwan. Using Propensity-score matching by sociodemographic factors and medical conditions, we selected 22,832 people without epilepsy as a non-exposed cohort for comparison. Follow-up events of diabetes from January 1, 2000 until December 31, 2013 were ascertained from medical claims. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with epilepsy were calculated using multiple Cox proportional hazard models. In the diabetes admission analysis, we identified 92,438 hospitalized diabetes patients, 930 of whom had a history of epilepsy. Adjusted odds ratios (ORs) and 95% CIs of adverse events after diabetes associated with previous epilepsy were calculated using multiple logistic regressions. The adjusted HR of diabetes in the cohort with epilepsy was 1.31 (95% CI 1.14–1.50) compared to the non-epilepsy cohort. Previous epilepsy was associated with post-diabetes adverse events, such as pneumonia (OR 1.68, 95% CI 1.37–2.07), urinary tract infection (OR 1.83, 95% CI 1.55–2.16), and septicemia (OR 1.34, 95% CI 1.09–1.65). In conclusion, epilepsy was associated with higher risk of diabetes and adverse post-diabetes outcomes. Diabetes prevention and attention to post-diabetes adverse events are needed for this susceptible population.
Low serum vitamin D concentrations in Spring-born dairy calves are associated with elevated peripheral leukocytes
Authors: Flores-Villalva Susana , O’Brien Megan B. , Reid Cian , Lacey Seán , Gordon Stephen V. , Nelson Corwin , Meade Kieran G. 
Published: September 2021

AbstractA role for vitamin D in the immune system is emerging from human research but data in the bovine is limited. In the current study, 48 Holstein–Friesian calves were randomly assigned to one of 4 groups designed to expose calves to divergent vitamin D levels for a 7 month period and to determine its effects on circulating immunity in young calves. Concentrations of circulating 25-hydroxyvitamin D (25OHD) was measured in serum using a commercial ELISA with validated bovine standards. Results showed that mean circulating concentrations of 25OHD at birth was 7.64 ± 3.21 ng/ml indicating vitamin D deficiency. Neither the injection of Vit D3 at birth nor the elevated levels in milk replacer yield discernible changes to pre-weaning circulating concentration of 25OHD. No calf reached the recommended level of vitamin D immune sufficiencyof 30 ng/ml of 25OHD until at least 3 months of age (T4). Increasing dietary Vit D3 via ration in the post-weaning period significantly elevated 25OHD concentrations in serum in VitD-In calves. Maximal levels of circulating 25OHD were achieved in VitD-Out calves, reaching 60.86 ± 7.32 ng/ml at 5 months of age (T7). Greatest divergence in haematology profile was observed between Ctl-In vs VitD-In groups with Ctl-In calves showing an elevated count of neutrophils, eosinophils, and basophils associated with reduced 25OHD concentrations. Neither IL-8 expression nor ROS production in serum were significantly different between calves with high and low 25OHD, indicating that other vitamin D-dependent mechanisms may contribute to the divergent circulating cellular profiles observed. This novel data on the vitamin D status of neonatal calves identifies a significant window of vitamin D insufficiency which is associated with significant differences in circulating immune cell profiles. Vitamin D insufficiency may therefore exacerbate pre-weaning disease susceptibility, and further work in now warranted.
Genetic analysis by targeted next-generation sequencing and novel variation identification of maple syrup urine disease in Chinese Han population
Authors: Fang Xiaohua , Zhu Xiaofan , Feng Yin , Bai Ying , Zhao Xuechao , Liu Ning , Kong Xiangdong 
Published: September 2021

AbstractMaple syrup urine disease (MSUD) is a rare autosomal recessive disorder that affects the degradation of branched chain amino acids (BCAAs). Only a few cases of MSUD have been documented in Mainland China. In this report, 8 patients (4 females and 4 males) with MSUD from 8 unrelated Chinese Han families were diagnosed at the age of 6 days to 4 months. All the coding regions and exon/intron boundaries of BCKDHA, BCDKHB, DBT and DLD genes were analyzed by targeted NGS in the 8 MSUD pedigrees. Targeted NGS revealed 2 pedigrees with MSUD Ia, 5 pedigrees with Ib, 1 pedigree with MSUD II. Totally, 13 variants were detected, including 2 variants (p.Ala216Val and p.Gly281Arg) in BCKDHA gene, 10 variants (p.Gly95Ala, p.Ser171Pro, p.Phe175Leu, p.Arg183Trp, p.Lys222Thr, p.Arg285Ter, p.Arg111Ter, p.S184Pfs*46, p.Arg170Cys, p.I160Ffs*25) in BCKDHB gene, 1 variant (p.Arg431Ter) in DBT gene. In addition, 4 previously unidentified variants (p.Gly281Arg in BCKDHA gene, p.Ser171Pro, p.Gly95Ala and p.Lys222Thr in BCKDHB gene) were identified. NGS plus Sanger sequencing detection is effective and accurate for gene diagnosis. Computational structural modeling indicated that these novel variations probably affect structural stability and considered as likely pathogenic variants.
Optimization of Burgers creep damage model of frozen silty clay based on fuzzy random particle swarm algorithm
Authors: Yao Yafeng , Cheng Hua , Lin Jian , Ji Jingchen 
Published: September 2021

AbstractThe creep characteristics of frozen rock and soil are crucial for construction safety in cases of underground freezing. Uniaxial compression tests and uniaxial creep tests were performed at temperatures of − 10, − 15, − 20, and − 25 °C for silty clay used in Nantong metro freezing construction to investigate the effect law of the stress–strain curves and creep curves. However, owing to the complex effects of factors such as temperature and ground pressure, the mechanical properties of underground frozen silty clay are uncertain. The Burgers creep damage model was established by using an elastic damage element to simulate the accelerated creep stage. The traditional particle swarm optimization algorithm was improved using the inertia weight and the fuzzy random coefficient. The creep parameters of the Burgers damage model were optimized using the improved fuzzy random particle swarm algorithm at different temperatures and pressure levels. Engineering examples indicated that the optimized creep model can more effectively characterize the creep stages of frozen silty clay in Nantong metro freezing construction. The improved fuzzy random particle swarm algorithm has wider engineering applicability and faster convergence than the traditional algorithm.
Polycyclic aromatic hydrocarbons in permafrost peatlands
Authors: Pastukhov Alexander , Loiko Sergey , Kaverin Dmitry 
Published: September 2021

AbstractThe concentrations of 15 individual PAHs in 93 peat cores have been determined by using high-performance liquid chromatography methods. In the profile the qualitative and quantitative composition of PAHs was non-uniform estimated in a wide range: from 112 to 3673 ng/g with mean 1214 ± 794 ng/g. Among 15 identified individual PAHs, the main contribution to their total amount was made by heavy highly condensed PAHs in the Eastern European peat plateaus, in particular, 6-nuclear benzo[ghi]perylene (1021 ± 707 ng/g), whereas in West Siberian permafrost peatlands, light PAHs were dominating, mostly naphthalene and phenanthrene (211 ± 87 and 64 ± 25 ng/g, respectively). The grass-equisetum peat contained the maximum of heavy PAHs and the dwarf shrub-grass—the minimum. In grass-dwarf shrub, grass-moss and moss peat, the share of 2-nuclear PAHs was most significant: naphthalene and fluorene, as well as 6-nuclear benzo[ghi]perylene. The presence of benzo[ghi]perylene in the entire peat strata, including its permafrost layer, was a marker of the anaerobic conditions that persisted throughout the Holocene and they were necessary for the synthesis of this compound.
A machine learning approach for efficient multi-dimensional integration
Authors: Yoon Boram 
Published: September 2021

AbstractMany physics problems involve integration in multi-dimensional space whose analytic solution is not available. The integrals can be evaluated using numerical integration methods, but it requires a large computational cost in some cases, so an efficient algorithm plays an important role in solving the physics problems. We propose a novel numerical multi-dimensional integration algorithm using machine learning (ML). After training a ML regression model to mimic a target integrand, the regression model is used to evaluate an approximation of the integral. Then, the difference between the approximation and the true answer is calculated to correct the bias in the approximation of the integral induced by ML prediction errors. Because of the bias correction, the final estimate of the integral is unbiased and has a statistically correct error estimation. Three ML models of multi-layer perceptron, gradient boosting decision tree, and Gaussian process regression algorithms are investigated. The performance of the proposed algorithm is demonstrated on six different families of integrands that typically appear in physics problems at various dimensions and integrand difficulties. The results show that, for the same total number of integrand evaluations, the new algorithm provides integral estimates with more than an order of magnitude smaller uncertainties than those of the VEGAS algorithm in most of the test cases.
Bio-oriented synthesis of new sulphadiazine derivatives for urease inhibition and their pharmacokinetic analysis
Authors: Hamad Asad , Khan Mohsin Abbas , Ahmad Irshad , Khalil Ruqaiya , Khalid Muhammad , Abbas Urva , Azhar Rahat , Uddin Jalal , Batiha Gaber El-Saber , Khan Ajmal , Shafiq Zahid , Al-Harrasi Ahmed 
Published: September 2021

AbstractCurrent research is based on biology-oriented synthesis of sulphadiazine derivatives and determination of their urease inhibitory activity. In this regard, a series of (E)-4-(benzylideneamino)-N-(pyrimidin-2-yl)benzenesulfonamide was synthesized from sulphadiazine and substituted aromatic aldehydes. The structures of synthesized compounds were ascertained by spectroscopic techniques, such as, FTIR, NMR and HRMS analysis, and in-vitro and in-silico investigation were carried out for the inhibition of urease. Ureases are harmful for humans by producing by-products of urea (ammonia and carbon dioxide). The most active compound (3l) against urease exhibited IC50value of 2.21 ± 0.45 µM which is 10 times more potent than the standard thiourea (20.03 ± 2.06 µM). It is noteworthy that most of our synthesized compounds showed significant to excellent activities against urease enzyme and most of them substituted by halogen or hydroxy groups atorthoandparapositions in their structures. Inhibition of enzyme by the synthesized analogues was in descending order as 3l > 3a > 3b > 3q > 3e > 3o > 3s > 3t > 3g > 3k > 3r > 3f > 3m > 3p > 3n > 3j > 3i > 3h. Moreover, molecular docking studies were performed to rationalize the binding interactions of the synthesized motifs with the active pocket of the urease enzyme. The synthesized sulphadiazine derivatives (3a–u) were found to be non-toxic, and presented passive gastrointestinal absorption.
Thyroid diseases and second to fourth digit ratio in Polish adults
Authors: Pruszkowska-Przybylska Paulina , Kobus Magdalena , Iljin Aleksandra , Wiktorska Joanna A. , Żądzińska Elżbieta , Sitek Aneta 
Published: September 2021

AbstractThe association between second to fourth finger ratio and thyroid diseases is unexplained. There is a possible interaction between prenatal exposition to sex hormone and thyroid functions in the adulthood. The study included 175 adults investigated in Łódź in the central Poland. It consisted of two main parts: a survey including questions about occurrence of thyroid gland dysfunction and anthropometric measurements (body mass and height and length of the second and fourth finger, waist and hip circumferences). The women who had thyroid disease had higher 2D:4D digit ratio (left hand) (mean = 1.004; SD = 0.036) than healthy ones (mean = 0.989; SD = 0.030) (t = − 2105; p = 0.038; d = 0.707). The association between thyroid diseases occurrence and prenatal steroid hormone exposition is noticed. Only females who had thyroid diseases tend to have higher 2D:4D digit ratio, for left hand.
Novel composite materials of modified roasted date pits using ferrocyanides for the recovery of lithium ions from seawater reverse osmosis brine
Authors: Al-Absi Rana S. , Abu-Dieyeh Mohammed H. , Ben-Hamadou Radhouane , Nasser Mustafa S. , Al-Ghouti Mohammad A. 
Published: September 2021

AbstractIn this paper, novel composite materials from modified roasted date pits using ferrocyanides were developed and investigated for the recovery of lithium ions (Li+) from seawater reverse osmosis (RO) brine. Two composite materials were prepared from roasted date pits (RDP) as supporting material, namely potassium copper hexacyanoferrate-date pits composite (RDP-FC-Cu), and potassium nickel hexacyanoferrate-date pits composite (RDP-FC-Ni). The physiochemical characterization of the RO brine revealed that it contained a variety of metals and salts such as strontium, zinc, lithium, and sodium chlorides. RDP-FC-Cu and RDP-FC-Ni exhibited enhanced chemical and physical characteristics than RDP. The optimum pH, which attained the highest adsorption removal (%) for all adsorbents, was at pH 6. In addition, the highest adsorption capacities for the adsorbents were observed at the initial lithium concentration of 100 mg/L. The BET surface area analysis confirmed the increase in the total surface area of the prepared composites from 2.518 m2/g for RDP to 4.758 m2/g for RDP-FC-Cu and 5.262 m2/g for RDP-FC-Ni. A strong sharp infrared peak appeared for the RDP-FC-Cu and RDP-FC-Ni at 2078 cm−1. This peak corresponds to the C≡N bond, which indicates the presence of potassium hexacyanoferrate, K4[Fe(CN)6]. The adsorption removal of lithium at a variety of pH ranges was the highest for RDP-FC-Cu followed by RDP-FC-Ni and RDP. The continuous increase in the adsorption capacity for lithium with increasing initial lithium concentrations was also observed. This could be mainly attributed to enhance and increased lithium mass transfer onto the available adsorption active sites on the adsorbents’ surface. The differences in the adsorption in terms of percent adsorption removal were clear and significant between the three adsorbents (P value < 0.05). All adsorbents in the study showed a high lithium desorption percentage as high as 99%. Both composites achieved full recoveries of lithium from the RO brine sample despite the presence of various other competing ions.
Comparison of SpO2 and heart rate values on Apple Watch and conventional commercial oximeters devices in patients with lung disease
Authors: Pipek Leonardo Zumerkorn , Nascimento Rafaela Farias Vidigal , Acencio Milena Marques Pagliarelli , Teixeira Lisete Ribeiro 
Published: September 2021

AbstractLung diseases have high mortality and morbidity, with an important impact on quality of life. Hypoxemic patients are advised to use oxygen therapy to prolong their survival, but high oxygen saturation (SpO2) levels can also have negative effects. Pulse oximeters are the most common way to assess oxygen levels and guide medical treatment. This study aims to assess whether wearable devices can provide precise SpO2 measurements when compared to commercial pulse oximeters. This is a cross-section study with 100 patients with chronic obstructive pulmonary disease and interstitial lung disease from an outpatient pneumology clinic. SpO2 and heart rate data were collected with an Apple Watch Series 6 (Apple) and compared to two commercial pulse oximeters. The Bland–Altman method and interclass correlation coefficient were used to compare their values. We observed strong positive correlations between the Apple Watch device and commercial oximeters when evaluating heart rate measurements (r = 0.995, p < 0.001) and oximetry measurements (r = 0.81, p < 0.001). There was no statistical difference in the evaluation of skin color, wrist circumference, presence of wrist hair, and enamel nail for SpO2 and heart rate measurements in Apple Watch or commercial oximeter devices (p > 0.05). Apple Watch 6 is a reliable way to obtain heart rate and SpO2 in patients with lung diseases in a controlled environment.
Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar
Authors: Haris Basma , Ahmed Ikhlak , Syed Najeeb , Almabrazi Hakeem , Saraswathi Saras , Al-Khawaga Sara , Saeed Amira , Mundekkadan Shihab , Mohammed Idris , Sharari Sanaa , Hawari Iman , Hamed Noor , Afyouni Houda , Abdel-Karim Tasneem , Mohammed Shayma , Khalifa Amel , Al-Maadheed Maryam , Zyoud Mahmoud , Shamekh Ahmed , Elawwa Ahmed , Karim Mohammed Y. , Al-Khalaf Fawziya , Tatari-Calderone Zohreh , Petrovski Goran , Hussain Khalid 
Published: September 2021

AbstractTo describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0–18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, p value = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. The incidence of T1DM in Qatar is the fourth highest in the world, IA2 autoantibody was the most specific with some patients only having ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 autoantibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.
Decompression of the suprascapular nerve at the suprascapular notch under combined arthroscopic and ultrasound guidance
Authors: Prenaud Clément , Loubeyre Jeanne , Soubeyrand Marc 
Published: September 2021

AbstractDecompression of the suprascapular nerve (SSNe) at the suprascapular notch (SSNo) is usually performed with an arthroscopic procedure. This technique is well described but locating the nerve is complex because it is deeply buried and surrounded by soft tissue. We propose to combine ultrasound and arthroscopy (US-arthroscopy) to facilitate nerve localization, exposure and release. The main objective of this study was to assess the feasibility of this technique. This is an experimental, cadaveric study, carried out on ten shoulders. The first step of our technique is to locate the SSNo using an ultrasound scanner. Then an arthroscope is introduced under ultrasound control to the SSNo. A second portal is then created to dissect the pedicle and perform the ligament release. Ultrasound identification of the SSNo, endoscopic dissection and decompression of the nerve were achieved in 100% of cases. Ultrasound identification of the SSNo took an average of 3 min (± 4) while dissection and endoscopic release time took an average of 8 min (± 5). Ultrasound is an extremely powerful tool for non-invasive localization of nerves through soft tissues, but it is limited by the fact that tissue visualization is limited to the ultrasound slice plane, which is two-dimensional. On the other hand, arthroscopy (extra-articular) allows three-dimensional control of the surgical steps performed, but the locating of the nerve involves significant tissue detachment and a risk of damaging the nerve with the dissection. The combination of the two (US-arthroscopy) offers the possibility of combining the advantages of both techniques.
Modeling seasonal emergence of Poa annua in urban greenspace
Authors: Taylor Dallas R. , Prorock Michael , Horvath Brandon J. , Brosnan James T. 
Published: September 2021

AbstractTurfgrasses are perennial components of urban greenspaces found in parks, recreational areas, golf courses, sports fields, and lawns that confer many ecosystem services. A copious seed producer, Poa annua is the most troublesome weed of turfgrass and continually threatens the ecosystem services provided by urban greenspaces. Field research was conducted in Knoxville, TN to better understand environmental conditions triggering P. annua seedling emergence patterns to assist managers with optimally timing interventions—both chemical and non-chemical—for control. Fluctuations in cooling degree day (CDD21C) accumulation accounted for 82% of the variance in yearly cumulative P. annua emergence data collected in a single irrigated sward of hybrid bermudagrass [C. dactylon (L.) Pers. x. C. transvaalensis Burtt-Davy]. However, non-linear models using CDD21C data developed ex post were not able to accurately predict P. annua emergence patterns ex ante. In both years, P. annua emergence changed most rapidly between the 40th and 43rd week of the year when seven-day mean soil temperature and rainfall were 18.9 °C and 12.7 mm, respectively. Future research should explore the efficacy of herbicide mixtures applied when P. annua emergence is most rapidly changing in lieu of developing models to predict when specific emergence thresholds occur.
Synthesis, delivery, and molecular docking of fused quinolines as inhibitor of Hepatitis A virus 3C proteinase
Authors: Jorshari Mehrnaz Rafiei , Mamaghani Manouchehr , Jahanshahi Parivash 
Published: September 2021

AbstractIt is widely accepted that Hepatitis A virus (HAV) is responsible for liver failure and even death in older people and in people with other serious health issues; so, proposing new compounds with inhibitory activity can help to treated of these disease’s. In current study, a new class of quinolines is proposed with inhibitor activity of the HAV proteinase. So, in the first step, fused quinoline derivatives has been synthesized in short reaction time (12.0 min) and high efficiency yields (94%) in presence of 1-carboxymethyl-2,3-dimethylimidazolium iodide ([cmdmim]I) ionic liquid catalyst using a new method. In the following, chemical reactivity and inhibitory activity of synthesized quinolines were evaluated in density functional theory (DFT) framework and molecular docking methodologies. High global softness (0.67 eV), low HOMOSWBNNT-LUMO4a gap (4.78 eV), and more negative adsorption energy (− 87.9 kJ mol−1) in these quinolines reveal that the 4a and 4b compounds have better delivery than other quinolines using SWBNNT as suitable carrier to target cells. Molecular docking shows that the best cavity of the HAV has − 134.2 kJ mol−1 interaction energy involving bonding and non-bonding interactions. In fact, these interactions are between fused quinolines with especial geometries and sidechain flexibility amino acids residues inside the best binding site of the HAV, as hydrogen bonding, steric, and electrostatic interactions. So, these interactions imply that proposed fused quinolines have good inhibitor activity for the HAV.