bluuebunny/crossref_metadata_2025_split huggingface dataset:
The microstructural change causing the failure of the Cox-Merz rule in Newtonian suspensions: experiments and simulations
Authors: Carotenuto Claudia , Rexha Genta , Martone Raffaella , Minale Mario 
Published: April 2021

AbstractNewtonian non-Brownian concentrated suspensions show a mismatch between the steady state and the complex viscosity, whatever the strain amplitude imposed in the oscillatory flow. This result is counterintuitive in the two extreme cases of vanishing strain amplitude and very large one. In the first case, the oscillatory flow should not be able to alter the steady microstructure, as well as in the other opposite limit for which the strain amplitude is so high that the oscillatory flow resembles a steady flow reversal. If the microstructure is not altered with respect to the steady one, similarly the complex viscosity should be equal to the steady one. We here investigate experimentally and numerically the origin of the viscosities mismatch at any imposed strain amplitude. We focus on the first two or three cycles of oscillations and different particle concentrations. Experimental and numerical results agree and allow to prove that for intermediate amplitudes, the oscillatory shear induces the breakage of particle clusters and the microstructure modifies so to minimise particle collisions. For very small strain amplitudes, the oscillatory shear only induces the rotation of few couples of touching particles and the complex viscosity results slightly smaller than the steady one, while for very large strains, the oscillatory flow reshuffles the particles inducing a microstructure as clustered as the steady state one but with a different angular distribution function. We show that the vast majority of the microstructure rearrangement takes place in the first half cycle of oscillation.
Lithospheric mantle refertilization by DMM-derived melts beneath the Cameroon Volcanic Line—a case study of the Befang xenolith suite (Oku Volcanic Group, Cameroon)
Authors: Tedonkenfack Sylvin S. T. , Puziewicz Jacek , Aulbach Sonja , Ntaflos Theodoros , Kaczmarek Mary-Alix , Matusiak-Małek Magdalena , Kukuła Anna , Ziobro Małgorzata 
Published: April 2021

AbstractThe origin and evolution of subcontinental lithospheric mantle (SCLM) are important issues of Earth’s chemical and physical evolution. Here, we report detailed textural and chemical analyses on a mantle xenolith suite from Befang (Oku Volcanic Group, Cameroon Volcanic Line), which represents a major tectono-magmatic structure of the African plate. The samples are sourced from spinel-facies mantle and are dominated by lherzolites. Their texture is cataclastic to porphyroclastic, and foliation defined by grain-size variation and alignment of spinel occurs in part of peridotites. Spinel is interstitial and has amoeboidal shape. Clinopyroxene REE patterns are similar to those of Depleted MORB Mantle (DMM) except LREEs, which vary from depleted to enriched. The A-type olivine fabric occurs in the subset of one harzburgite and 7 lherzolites studied by EBSD. Orthopyroxene shows deformation consistent with olivine. The fabric of LREE-enriched clinopyroxene is equivalent to those of orthopyroxene and olivine, whereas spinel and LREE-depleted clinopyroxene are oriented independently of host rock fabric. The textural, chemical and thermobarometric constraints indicate that the Befang mantle section was refertilised by MORB-like melt at pressures of 1.0–1.4 GPa and temperatures slightly above 1200–1275 °C. The olivine-orthopyroxene framework and LREE-enriched clinopyroxene preserve the protolith fabric. In contrast, the LREE-depleted clinopyroxene, showing discordant deformation relative to the olivine-orthopyroxene protolith framework, and amoeboidal spinel crystallized from the infiltrating melt. The major element and REEs composition of minerals forming the Befang peridotites indicate subsequent reequilibration at temperatures 930–1000 °C. This was followed by the formation of websterite veins in the lithospheric mantle, which can be linked to Cenozoic volcanism in the Cameroon Volcanic Line that also brought the xenoliths to the surface. This study therefore supports the origin of fertile SCLM via refertilization rather than by extraction of small melt fractions, and further emphasizes the involvement of depleted melts in this process.
Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury
Authors: Bohnert Simone , Wirth Christoph , Schmitz Werner , Trella Stefanie , Monoranu Camelia-Maria , Ondruschka Benjamin , Bohnert Michael 
Published: April 2021

AbstractThe aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in forensic diagnostics when examining cadaveric cerebrospinal fluid (CSF) biochemically via an enzyme-linked immunosorbent assay (ELISA) and comparing the corresponding brain tissue in fatal traumatic brain injury (TBI) autopsy cases by immunocytochemistry versus immunohistochemistry. In 21 trauma and 19 control cases, CSF was collected semi-sterile after suboccipital puncture and brain specimens after preparation. The CSF MBP (p = 0.006) and NF-H (p = 0.0002) levels after TBI were significantly higher than those in cardiovascular controls. Immunohistochemical staining against MBP and against NF-H was performed on cortical and subcortical samples from also biochemically investigated cases (5 TBI cases/5 controls). Compared to the controls, the TBI cases showed a visually reduced staining reaction against MBP or repeatedly ruptured neurofilaments against NF-H. Immunocytochemical tests showed MBP-positive phagocytizing macrophages in CSF with a survival time of > 24 h. In addition, numerous TMEM119-positive microglia could be detected with different degrees of staining intensity in the CSF of trauma cases. As a result, we were able to document that elevated levels of MBP and NF-H in the CSF should be considered as usefulneuroinjurybiomarkers of traumatic brain injury.
Long-term outcomes of intravitreal activated protein C injection for ischemic central retinal vein occlusion: an extension trial
Authors: Hara Chikako , Kamei Motohiro , Sakaguchi Hirokazu , Matsumura Nagakazu , Sakimoto Susumu , Suzuki Mihoko , Nishida Kentaro , Fukushima Yoko , Nishida Kohji 
Published: April 2021

Abstract
Purpose
Our previous 1-year pilot study evaluated the efficacy of intravitreally injected activated protein C (APC) in 10 eyes with ischemic central retinal vein occlusion (CRVO). The reperfusion of the areas of retinal nonperfusion (RNP) exceeded 50% of the baseline in five (50%) eyes 1 year after the APC injection. The current study evaluated the long-term efficacy and safety of intravitreal APC.

Methods
The 10 eyes in the pilot study were included in this study. Other treatments were administered at the physicians’ discretion after the pilot study. We evaluated visual acuity (VA), central retinal thickness (CRT) and perfusion status, and adverse events and severity over the long term.

Results
The median follow-up was 60 months (range, 48–68 months). Compared with baseline, the post-treatment VA improved significantly (P < 0.001) from 1.39 to 1.06 logarithm of the minimum angle of resolution. The CRT improved significantly (P < 0.001) from 1090 to 195 μm at the last visit. The RNP areas decreased from an average 29.7 disc areas (DAs) at baseline to an average 16.5 DAs at the last examination (mean, 40 ± 6.5 months after the first APC treatment). No adverse events were related to intravitreal APC.

Conclusion
No complications were associated with intravitreal APC, the clinical course improved, and improved RNP was maintained for the long term, suggesting that intravitreal APC may be an alternative treatment for CRVO.
Hemispheric differences in altered reactivity of brain oscillations at rest after posterior lesions
Authors: Gallina Jessica , Pietrelli Mattia , Zanon Marco , Bertini Caterina 
Published: April 2021

AbstractA variety of evidence supports the dominance of the right hemisphere in perceptual and visuo-spatial processing. Although growing evidence shows a strong link between alpha oscillations and the functionality of the visual system, asymmetries in alpha oscillatory patterns still need to be investigated. Converging findings indicate that the typical alpha desynchronization occurring in the transition from the eyes-closed to the eyes-open resting state might represent an index of reactivity of the visual system. Thus, investigating hemispheric asymmetries in EEG reactivity at the opening of the eyes in brain-lesioned patients may shed light on the contribution of specific cortical sites and each hemisphere in regulating the oscillatory patterns reflecting the functionality of the visual system. To this aim, EEG signal was recorded during eyes-closed and eyes-open resting state in hemianopic patients with posterior left or right lesions, patients without hemianopia with anterior lesions and healthy controls. Hemianopics with both left and right posterior lesions showed a reduced alpha reactivity at the opening of the eyes, suggesting that posterior cortices have a pivotal role in the functionality of alpha oscillations. However, right-lesioned hemianopics showed a greater dysfunction, demonstrated by a reactivity reduction more distributed over the scalp, compared to left-lesioned hemianopics. Moreover, they also revealed impaired reactivity in the theta range. This favors the hypothesis of a specialized role of the right hemisphere in orchestrating oscillatory patterns, both coordinating widespread alpha oscillatory activity and organizing focal processing in the theta range, to support visual processing at the opening of the eyes.
Multi-trophic communities re-establish with canopy cover and microclimate in a subtropical forest biodiversity experiment
Authors: Fornoff Felix , Staab Michael , Zhu Chao-Dong , Klein Alexandra-Maria 
Published: April 2021

AbstractPlant diversity affects multi-trophic communities, but in young regrowth forests, where forest insects are in the process of re-establishment, other biotic and also abiotic factors might be more important. We studied cavity-nesting bees, wasps and their natural enemies along an experimental tree diversity gradient in subtropical South-East China. We compared insect communities of experimental young forests with communities of established natural forests nearby the experiment and tested for direct and indirect effects of tree diversity, tree basal area (a proxy of tree biomass), canopy cover and microclimate on bee and wasp community composition, abundance and species richness. Finally, we tested if the trophic levels of bees, herbivore-hunting wasps, spider-hunting wasps and their natural enemies respond similarly. Forest bee and wasp community composition re-established towards communities of the natural forest with increasing tree biomass and canopy cover. These factors directly and indirectly, via microclimatic conditions, increased the abundance of bees, wasps and their natural enemies. While bee and wasp species richness increased with abundance and both were not related to tree diversity, abundance increased directly with canopy cover, mediated by tree biomass. Abundance of natural enemies increased with host (bee and wasp) abundance irrespective of their trophic position. In conclusion, although maximizing tree diversity is an important goal of reforestation and forest conservation, rapid closure of canopies is also important for re-establishing communities of forest bees, wasps and their natural enemies.
Material parameter identification using finite elements with time-adaptive higher-order time integration and experimental full-field strain information
Authors: Hartmann Stefan , Gilbert Rose Rogin 
Published: April 2021

AbstractIn this article, we follow a thorough matrix presentation of material parameter identification using a least-square approach, where the model is given by non-linear finite elements, and the experimental data is provided by both force data as well as full-field strain measurement data based on digital image correlation. First, the rigorous concept of semi-discretization for the direct problem is chosen, where—in the first step—the spatial discretization yields a large system of differential-algebraic equation (DAE-system). This is solved using a time-adaptive, high-order, singly diagonally-implicit Runge–Kutta method. Second, to study the fully analytical versus fully numerical determination of the sensitivities, required in a gradient-based optimization scheme, the force determination using the Lagrange-multiplier method and the strain computation must be provided explicitly. The consideration of the strains is necessary to circumvent the influence of rigid body motions occurring in the experimental data. This is done by applying an external strain determination tool which is based on the nodal displacements of the finite element program. Third, we apply the concept of local identifiability on the entire parameter identification procedure and show its influence on the choice of the parameters of the rate-type constitutive model. As a test example, a finite strain viscoelasticity model and biaxial tensile tests applied to a rubber-like material are chosen.
Deformation of framed curves with boundary conditions
Authors: Hornung Peter 
Published: April 2021

AbstractWe provide a general approach to deform framed curves while preserving their clamped boundary conditions (this includes closed framed curves) as well as properties of their curvatures. We apply this to director theories, which involve a curve $$\gamma : (0, 1)\rightarrow \mathbb {R}^3$$

γ
:

(
0
,
1
)

→

R

3

and orthonormal directors $$d_1$$

d
1

, $$d_2$$

d
2

, $$d_3: (0,1)\rightarrow \mathbb {S}^2$$

d
3

:

(
0
,
1
)

→

S

2

with $$d_1 = \gamma '$$

d
1

=

γ
′

. We show that $$\gamma $$
γ
and the $$d_i$$

d
i

can be approximated smoothly while preserving clamped boundary conditions at both ends. The approximation process also preserves conditions of the form $$d_i\cdot d_j' = 0$$

d
i

·

d
j
′

=
0

. Moreover, it is continuous with respect to natural functionals on framed curves. In the context of $$\Gamma $$
Γ
-convergence, our approach allows to construct recovery sequences for director theories with prescribed clamped boundary conditions. We provide one simple application of this kind. Finally, we use similar ideas to derive Euler–Lagrange equations for functionals on framed curves satisfying clamped boundary conditions.
Millimeter-wave enabled PAM-4 data transmission over hybrid FSO-MMPOF link for access networks
Authors: Iqbal Saeed , Raza Aadil , Butt Muhammad Fasih Uddin , Mirza Jawad , Iqbal Muhammad , Ghafoor Salman , El-Hajjar Mohammed 
Published: April 2021

AbstractIn this paper, we propose a full duplex architecture based on a hybrid link composed of free space optics (FSO) and multimode plastic optical fiber (MMPOF) for short-range wireless access networks. The proposed architecture employs mode group division multiplexing (MGDM) and wavelength reuse techniques to transmit data between central unit (CU) and radio access units (RAUs). An optical frequency comb source to generate multiple optical sidebands is realized using a single laser source to provide 60 GHz millimeter-wave (mm-wave) signals at each RAU by simultaneously transmitting PAM-4 signal on linearly polarized (LP) modes of each optical sideband. Data rate of 2$$\times$$
×
12 Gbps at mm-wave frequency of 60 GHz is achieved for both downlink (DL) and uplink (UL) transmissions. The transmission of 2$$\times$$
×
12 Gbps PAM-4 signal over hybrid FSO-MMPOF link is investigated at different values of refractive index structure parameter ($$C_n^2$$

C
n
2

) by employing log-normal (LN) FSO channel model to support three RAUs in a ring topology. The acceptable receiver sensitivities below −5 and −0.6 dBm for DL and UL transmissions are achieved, respectively. The proposed hybrid architecture can be a potential candidate for future communication networks.
Unidirectional porous beta-tricalcium phosphate and hydroxyapatite artificial bone: a review of experimental evaluations and clinical applications
Authors: Funayama Toru , Noguchi Hiroshi , Kumagai Hiroshi , Sato Kosuke , Yoshioka Tomokazu , Yamazaki Masashi 
Published: April 2021

AbstractIn Japan, where allograft bone transplantation is not widespread, prospects for artificial bones are very high. Therefore, artificial bones with various compositions, porous structures, and porosities have been developed and employed for clinical use. Both Affinos® and Regenos® (made of beta-tricalcium phosphate and hydroxyapatite, respectively) are artificial bones with a unique unidirectional porous structure, in which pores with a diameter suitable for tissue penetration (25–300 μm) are aligned in one direction. The unidirectional porous structure allows rapid penetration of blood deep into the materials by a capillary effect. In animal experiments, Affinos® showed well-balanced resorption and was replaced with the host’s own bone from an early stage after implantation and new bone formation and remodeling were observed in the cortical bone and medullary cavity. When implanted for clinical situation, resorption from an early stage and good replacement with the patient’s own bone were also observed. Regenos® has an internal osteon-like material and a vascular-like structure that is maintained within the pores even after long-term implantation, as noted in an animal experiment. When implanted for clinical situation, good osteoconductivity was observed from an early stage of implantation. In addition, the material was observed to be slowly absorbed over time in some cases. We have discussed the beneficial effects of combining teriparatide and platelet-rich plasma impregnation and the potential prospects of these artificial bones.
Study on the correlation between the circle of Willis structure and collateral circulation in bilateral carotid artery occlusion
Authors: Liu Yang , Zhu Lei , Hou Bei , Wang Tuoyi , Xu Dechao , Tan Chenxi , Zhang Huiyi , Li Chunyan , Wang Jianan 
Published: April 2021

Abstract
Background and purpose
Bilateral carotid artery occlusion (CAO) is a rare condition and the collateral circulation is more complicated than in unilateral CAO. The circle of Willis (CoW) is the most important collateral circulation compensation pathway in CAO. However, the specific role of CoW in the collateral circulation compensation pathway of CAO has not been fully elucidated. The purpose of this study is to investigate the role of CoW in the collateral circulation compensation pathway of CAO.

Materials and methods
Clinical, imaging, and hemodynamic data of 30 patients with bilateral CAO were collected to analyze the collateral blood flow compensation pathway and its characteristics, and to examine the correlation between the structure of the CoW and the collateral circulation of bilateral CAO.

Results
This paper summarized 30 patients with bilateral CAO. There were 0 cases of the CoW complete type, 18 cases of the partially complete type (60%), and 12 cases of the incomplete type (40%). For the partially complete type cases, there were 14 complete anterior circulation cases (46.7%). The collateral circulation collateral circulation pathway included 14 cases with anterior communicating artery(ACoA), 7 cases with posterior cerebral artery (PCA)-middle cerebral artery (MCA) leptomeningeal anastomosis (LMA), 5 cases with ophthalmic artery(OA), 3 cases with lateral posterior communicating artery(PCoA), 1 case with internal carotid artery (ICA) stealing, 1 case with new Moyamoya vessels, and 4 cases of other types. There were four cases (13.3%) with complete posterior circulation, including four cases with bilateral PCoA, three cases with PCA-MCA LMA, and two cases with OA. There were 12 cases (40%) with incomplete CoW, including 8 cases with PCA-MCA LMA, 3 cases with lateral PCoA, 1 case with anterior cerebral artery (ACA)-MCA LMA, 4 cases with OA, and 1 other case.

Conclusion
The collateral circulation pathway differs among patients with different CoW structure types. When the CoW is partially complete, it mainly provides blood flow compensation to the ischemic area through primary collateral circulation. When the CoW is incomplete, it mainly provides blood flow compensation to the ischemic area through secondary collateral circulation.
Knowledge networks and strong tie creation: the role of relative network position
Authors: Tsouri Maria 
Published: April 2021

AbstractThe proximity literature usually treats proximity in terms of common attributes shared by agents, disregarding the relative position of an actor inside the network. This paper discusses the importance of such dimension of proximity, labelled as in-network proximity, and proposes an empirical measurement for it, assessing its impact (jointly with other dimensions of proximity) on the creation of strong knowledge network ties in ICT in the region of Trentino. The findings show that actors with higher in-network proximity are more attractive for both other central actors and peripheral ones, which is further strengthening their position within the network. In detail, the centrally positioned actors repeat collaboration with other central actors in the network, as central actors gather more ‘reputation’, signalling that they will possess the needed knowledge resources. Relatively peripheral actors, either new or not so active inside the network, seek for collaboration with relatively central actors in order to tap on knowledge resources they do not acquire.
A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes
Authors: Peng Q. , Vermolen F. J. , Weihs D. 
Published: April 2021

AbstractThe phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429–1450, 2018), Vermolen and Gefen (BMM 12:301–323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340–348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework.