bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Theranostic Cellulose Nanocrystal‐Based Drug Delivery System with Enhanced Retention in Pulmonary Metastasis of Melanoma
Authors: Imlimthan Surachet , Khng You Cheng , Keinänen Outi , Zhang Wenzhong , Airaksinen Anu J. , Kostiainen Mauri A. , Zeglis Brian M. , Santos Hélder A. , Sarparanta Mirkka 
Published: March 2021

AbstractMetastatic melanoma can be difficult to detect until at the advanced state that decreases the survival rate of patients. Several FDA‐approved BRAF inhibitors have been used for treatment of metastatic melanoma, but overall therapeutic efficacy has been limited. Lutetium‐177 (177Lu) enables simultaneous tracking of tracer accumulation with single‐photon emission computed tomography and radiotherapy. Therefore, the codelivery of 177Lu alongside chemotherapeutic agents using nanoparticles (NPs) might improve the therapeutic outcome in metastatic melanoma. Cellulose nanocrystals (CNC NPs) can particularly deliver payloads to lung capillaries in vivo. Herein, 177Lu‐labeled CNC NPs loaded with vemurafenib ([177Lu]Lu‐CNC‐V NPs) is developed and the therapeutic effect in BRAF V600E mutation‐harboring YUMM1.G1 murine model of lung metastatic melanoma is investigated. The [177Lu]Lu‐CNC‐V NPs demonstrate favorable radiolabel stability, drug release profile, cellular uptake, and cell growth inhibition in vitro. In vivo biodistribution reveals significant retention of the [177Lu]Lu‐CNC‐V NPs in the lung, liver, and spleen. Ultimately, the median survival time of animals is doubly increased after treatment with [177Lu]Lu‐CNC‐V NPs compared to control groups. The enhanced therapeutic efficacy of [177Lu]Lu‐CNC‐V NPs in the lung metastatic melanoma animal model provides convincing evidence for the potential of clinical translation for theranostic CNC NP‐based drug delivery systems after intravenous administration.
The Economy, Nature, and the Meaning of Life After the Coronavirus Crisis
Authors: van Geest Paul , de Bourbon de Parme Carlos J. B. , Eijffinger Sylvester 
Published: March 2021

Abstract“Christians still regularly tell you that nature is so beautiful and testifies of God’s greatness and goodness. Oh, dear people, nature is downright terrible, nature is one great suffering... What is ‘very good’ about a creation in which the most terrible parasites live in humans and animals...? What is ‘very good’ about a creation in which all organisms are terrorized by parasites, including parasites themselves?” (‘t Hart, Wie God verlaat heeft niets te vrezen. De Schrift betwist, pp. 7–8; 1997). The words by Maarten ‘t Hart seem irrefutable. Now that the coronavirus causes a disease that makes us realize that life is not as malleable in everything as we wish, they would have been almost prophetic if he had added the word “viruses” after “the most terrible parasites.”Long before Maarten ‘t Hart, ancient philosophers refused to accept the idea that creation is only cruel and chaotic.In this chapter, we will discuss how every crisis is an opportunity to continue to grow, either personally or collectively, or to come to a deeper understanding. Bearing this in mind, the question arises as to how we can learn from the present coronavirus crisis. How should society be rearranged? How should we deal with nature of which humankind is a part?
Rethinking Education in a Crisis: How New Is a New Common Really?
Authors: Louwerse Max , Postma Marie , Horden Maarten , Sluijtman Anton 
Published: March 2021

AbstractThe COVID-19 pandemic has disrupted the status quo in many areas of society, including education. At all educational levels, on-site lecturing had to switch instantaneously to an online mode of instruction. This transition was so straightforward, that the argument could be made for online education to become a permanent fixture, particularly if it is more efficient, cheaper, and more effective than traditional education. Extensive meta-analyses, however, show that most online teaching practices do not lead to better educational outcomes than the on-site alternatives. Worse yet, the traditional face-to-face mode of lecturing is ineffective in the absence of personalized interactions. The proposed solutions are offered by artificial intelligence research, including virtual reality, intelligent tutoring systems, and serious games—solutions that have so far not been extensively implemented in practice. The current health crisis provides our educational professionals with an opportunity to rethink their teaching practices and focus on applying these promising new alternatives.
Involve Residents to Ensure Person-Centered Nursing Home Care During Crises Like the COVID-19 Outbreak
Authors: Luijkx Katrien , Janssen Meriam , Stoop Annerieke , van Boekel Leonieke , Verbiest Marjolein 
Published: March 2021

AbstractNursing homes aim to provide person-centered care and recognize residents as unique individuals with their own histories, life goals, and preferences. The life expectancy of nursing home residents is rather limited. Nursing homes have been hit hard by COVID-19 because of an increased risk of death and a total nursing home lockdown from March 19 until the end of May 2020. Although social relationships are a basic human need and the fulfillment of social needs is essential for both physical and mental health, nursing home residents were no longer allowed to meet their loved ones. This decision was taken without involving residents and their loved ones and without considering the psychosocial impact of such measures for residents and their loved ones. When visitors were again allowed in the nursing homes, this was valued highly. To enable decent decision-making, we call both the government and nursing homes to involve residents and their families in decision-making. It is essential to know how residents weigh the risk of a COVID-19 infection and the possible implication of them opposing social isolation. We have to adapt to a new common and need to stop talking about residents and their loved ones and start talking with them.
Fast Forward Science: Risks and Benefits in the Rapid Science of COVID-19
Authors: Wicherts Jelte 
Published: March 2021

AbstractSince the onset of the SARS-COV-2 pandemic in late 2019, the scientific literature on the SARS-COV-2 virus and the disease COVID-19 has a growth rate that resembles the growth in confirmed COVID-19 cases that continue to make media headlines all across the globe. Biomedical coronavirus research started slowly but increased to hundreds of articles per week—not unlike the spread of the virus itself. At the time of writing in mid-2020, around 2500 publications per week appear in PubMed on COVID-19 or SARS-COV-2. This new biomedical literature has emerged at an unprecedented but will the scientific community be able to end the suffering caused by the pandemic? Can we trust the insights from the rapidly emerging scientific literature on the coronavirus to implement wide-ranging social, economic, and health policies and vaccination programs? To answer these questions, I here relate the rapid science on the coronavirus pandemic to regular biomedical science and the meta-scientific insights on it. I focus my attention on peer reviews, open access, retractions, open data, and registration of studies.
The Paradox of Democracy in Popular Music Education: Intersectionalizing “Youth” Through Curriculum Analysis
Authors: Koskela Minja , Kuoppamäki Anna , Karlsen Sidsel , Westerlund Heidi 
Published: March 2021

AbstractIn this chapter, we unpack the complex politics of popular music education (PME) in schools through an examination of the ways in which youth and youth culture are represented in the Finnish National Core Curricula (2004 and 2014). Interrogating commonly held conceptualizations of diversity in music education, we identify a paradox in school-based PME which, on the one hand, aims toward democratic classroom practice yet, on the other, neglects diversity by approaching youth as a homogenous group. Challenging common analytical points of departure in PME research, we argue that scholars and educators need to recognize the multiple and intersecting identities of students if PME is to afford them equal opportunities for participation. Overall, we suggest that through the analytical lens of intersectionality, PME may be better positioned to take into account students’ own experiences of inequalities, providing new perspectives on diversity at the policy level. Thus, intersectionality could provide a useful analytical frame in the process of furthering further democratic practice in the classroom.
Educative Power and the Respectful Curricular Inclusion of Aboriginal and Torres Strait Islander Music
Authors: Webb Michael , Bracknell Clint 
Published: March 2021

AbstractThis chapter argues for the full, respectful curricular inclusion of Aboriginal and Torres Strait Islander music in order to promote a more balanced and equitable social and cultural vision of the nation-state in Australian schools. It challenges views that claim Indigenous cultures have been irretrievably lost or are doomed to extinction, as well as the fixation on musical authenticity. We propose that the gradual broadening of Indigenous musical expressions over time and the musical renaissance of the new millennium have created an unprecedented opportunity for current music educators to experience the educative power of Aboriginal and Torres Strait Islander music. This means that culturally nonexposed music teachers can employ familiar musical-technical approaches to the music even as they begin to more fully investigate the music’s cultural-contextual meanings. The chapter considers issues that impinge on the music’s educative power, especially those relating to its definition, its intended audiences, and pedagogies. It aims to help clear the way for the classroom to become an environment in which students can sense the depth and vitality of contemporary Australian Indigenous music.
To “Move, Surprise, and Thrill”: Thirty Years of Promoting Cultural Diversity in Norwegian School Concerts
Authors: Knudsen Jan Sverre 
Published: March 2021

AbstractThis chapter examines how a politics of cultural diversity was implemented over a 30-year period in a Norwegian school concert program run by Concerts Norway. Departing from a historical overview, the chapter outlines the shifting agendas, values, and visions of diversity that governed this ambitious cultural effort. A central aim is to examine the ideological positions that influenced the program and the political and educational debates surrounding it. The concert program is discussed with respect to cultural diversity and anti-racism, democracy, tradition, hybridity, and the tensions between educational and artwork-based paradigms. Based on theorizations of cultural difference, the chapter shows how promoting music to children has been understood as an important part of shaping societal attitudes and laying the grounds for an anti-oppressive education. Critical issues regarding representation, influence, and power in the staging of music involving immigrant performers are raised. The chapter relates the concert programs to the political frames and ideals of the nation-state by illustrating how international cooperation effectively made the concert programs a part of Norwegian foreign policy. It points out how changing government policies had a profound impact on programs promoting cultural diversity, eventually leading to their termination as a national cultural strategy.
The Challenges of Implementing Diverse Political Directives in Contemporary China: Between Creativity and Confucianism
Authors: Ho Wai-Chung 
Published: March 2021

AbstractThe People’s Republic of China (PRC) was founded as a communist state in 1949 within the framework of the collective leadership model under the Communist Party of China (the single-party system in China). After experiencing sociopolitical and economic changes, the PRC has moved to the free market economy of globalisation in the global age. The evolution of Chinese politics and the economic system has resulted in more diversity and changes in school education, along with struggles to adjust to these changes. Along this line, this chapter will examine the complex relationship between the politics of diversity, Confucianism, and creativity education, particularly in response to the views of Chinese teachers from Beijing via in-depth, semi-structured individual interviews on the implementation of a creativity policy in school music education. Based on current education policies and the interview data collected for this study on the examination of the nature of creativity, this chapter will conclude with a discussion of how school music education may help initiate a dialogue on the politics and nature of creativity and cultural identity in response to the challenges of contemporary political and cultural values between creativity and Confucianism that prevail in the global age of China.
A Gay Neighborhood or Merely a Temporary Cluster of “Strange” Bars? Gay Bar Culture in Antwerp
Authors: Eeckhout Bart , Herreman Rob , Dhoest Alexander 
Published: March 2021

AbstractThis chapter investigates the historical permutations of those areas that come closest to qualifying as lesbian and gay neighborhoods in Antwerp, the largest city in Flanders (the northern, Dutch-speaking part of Belgium). Although Antwerp has come to be represented as the “gay capital” of Flanders, it never developed a full-fledged gay neighborhood in the Anglo-American tradition of the concept. The clustering of sexual minorities in the city has been limited largely to the economic, social, and cultural business of (nightlife) entertainment, with lesbian and gay meeting places historically concentrating in particular neighborhoods that, moreover, have shifted over time and dissipated again. The chapter’s fine-grained analysis intends to reveal geographic, social, and cultural specificities for which a more detailed understanding of both the Antwerp and the Belgian contexts is necessary. Its tripartite structure is shaped by the specific heuristic conditions set by it. Because the larger historical context for the investigated subject remains to be written, the chapter first undertakes a substantial and panoramic survey of the emergence of gay nightlife in Antwerp during the early half of the twentieth century. This provides the framework needed for a more detailed analysis in the second part, which zooms in on an area in the immediate vicinity of the Central Station and takes as its emblematic focus one sufficiently long-term and iconic gay bar, called Café Strange. Finally, the chapter zooms out again to sketch how even such a limited gay nightlife cluster in Antwerp has evaporated again in the course of the twenty-first century, leaving a landscape that is hard to map and largely virtual.
Plateaus and Afterglows: Theorizing the Afterlives of Gayborhoods as Post-Places
Authors: Coffin Jack 
Published: March 2021

AbstractA number of commentators have acknowledged the decline of gayborhoods and the concomitant emergence of non-heteronormative diasporas in societies where sexual and gender diversity is normalized (Ghaziani 2015; Nash and Gorman-Murray 2017; Bitterman 2020). Academic studies tend to focus on the new lives that are being led beyond the gayborhood and the diminished distinctiveness of the territories left behind (e.g. Ghaziani 2014). In contrast, this chapter explores the possibility that gayborhoods can continue to influence sociospatial dynamics, even after their physical presence has diminished or disappeared altogether. Individuals and collectives may still be inspired by the memories, representations, and imaginaries previously provided by these erstwhile places. Indeed, the metaphor of a non-heteronormative diaspora relies on an ‘origin’ from which a cultural network has dispersed. In this sense gayborhoods can continue to function as post-places, as symbolic anchors of identity that operate even if they no longer exist in a material form, even if they are used simply as markers of ‘how far the diaspora has come’. The proposition that gayborhoods are becoming post-places could be more fully theorized in a number of ways, but the approach here is to adapt Deleuze and Guattari’s (1987: 22) notion of plateaus, which denote a “region of intensities whose development avoids any orientation towards a culmination point or external end”. From this perspective gayborhoods are not spatial phenomena that reach a climax of concentration and then disappear through dissipation. Instead, they can be described as becoming more intense and concrete in the latter half of the twentieth century before gradually fading after the new millennium as they disperse gradually into a diaspora as memories, habits, and so forth. Put another way, non-climactic gayborhoods leave ‘afterglows’, affects that continue to exert geographical effects in the present and near future. This conceptualization is consequential for theory, practice, and political activism, and ends the main body of this edited volume on a more ambitious note.
A Tale of Three Villages: Contested Discourses of Place-Making in Central Philadelphia
Authors: Niedt Greg 
Published: March 2021

AbstractAs the acceptance of queer identities has proceeded in fits and starts over the last few decades, the question has been raised, is it still necessary to have dedicated queer spaces? City dwellers often reason that with supposed improvements in safety and social mixing, the “gay ghettos” that form a transitional stage in neighborhood revitalization should now become common areas. Yet the capitalist logic that drives this thinking often trades the physical threat of exclusion or violence for an existential one, jeopardizing a distinctive culture that remains valuable in the self-realization process of local queer citizens. This is visible not only in changing demographics, but also in the production of discourse across multiple levels; language and semiotics help to constitute neighborhoods, but also toconceptualizethem. This chapter examines how public signs and artifacts reify and sustain three competing narratives of a single central Philadelphia neighborhood in flux: the traditionally queer “Gayborhood” that developed shortly after World War II, the officially designated “Washington Square West,” and the realtor-coined, recently gentrifying “Midtown Village.” I argue that the naming and describing of these spaces, and how their associated discourses are reflected by their contents, continues to play a role in the ongoing struggle for queer acceptance. Combining observational data of multimodal public texts (storefronts, flyers, street signs, etc.) and critical discourse analysis within the linguistic/semiotic landscapes paradigm, I present a critique of the presumed inevitability of queer erasure here. This is supplemented with a comparison of grassroots, bottom-up, and official, top-down documents in various media (maps, brochures, websites, social media, etc.) that perpetuate the different discourses. Ultimately, a change in urban scenery and how a neighborhood is envisioned only masks the fact that spaces of queer expression, marked by their eroding distinctiveness rather than their deviance, are still needed.
Toward Process Variability Management in Online Examination Process in German Universities: A State of the Art
Authors: Heidari Maryam , Arnold Oliver 
Published: March 2021

AbstractIn contemporary organizations, multiple variants of the same business process are often considerable. Such business process variability has caused considerable challenges, both while modeling processes and in their execution. In order to develop a new approach to managing process variants, or extend an existing one, in this research, we review the state of the art in a particular area: online examination processes. We show to what extent variability should be considered in exam processes, whether this is due to special legal restrictions and regulations, different exam frameworks, or even different technical infrastructure. This could be the foundation for developing an approach to managing process variability in the field of e-assessment. Initial findings indicate that examination processes have many similarities, but also considerable differentiation. Therefore, there an appropriate model needs to be developed in order to manage variability in e-assessment and the developed approach must then be validated in identifying faculties. This paper constitutes a first step in this direction.
Efficient Bounded Model Checking of Heap-Manipulating Programs using Tight Field Bounds
Authors: Ponzio Pablo , Godio Ariel , Rosner Nicolás , Arroyo Marcelo , Aguirre Nazareno , Frias Marcelo F. 
Published: March 2021

AbstractSoftware model checkers are able to exhaustively explore different bounded program executions arising from various sources of non-determinism. These tools provide statements to produce non-deterministic values for certain variables, thus forcing the corresponding model checker to considerallpossible values for these during verification. While these statements offer an effective way of verifying programs handling basic data types and simple structured types, they are inappropriate as a mechanism for nondeterministic generation of pointers, favoring the use of insertion routines to produce dynamic data structures when verifying, via model checking, programs handling such data types.We present a technique to improve model checking of programs handling heap-allocated data types, by taming the explosion of candidate structures that can be built when non-deterministically initializing heap object fields. The technique exploits precomputedrelational bounds, that disregard values deemed invalid by the structure’s type invariant, thus reducing the state space to be explored by the model checker. Precomputing the relational bounds is a challenging costly task too, for which we also present an efficient algorithm, based on incremental SAT solving.We implement our approach on top of the bounded model checker, and show that, for a number of data structures implementations, we can handle significantly larger input structures and detect faults that is unable to detect.
Probabilistic and Systematic Coverage of Consecutive Test-Method Pairs for Detecting Order-Dependent Flaky Tests
Authors: Wei Anjiang , Yi Pu , Xie Tao , Marinov Darko , Lam Wing 
Published: March 2021

AbstractSoftware developers frequently check their code changes by running a set of tests against their code. Tests that can nondeterministically pass or fail when run on the same code version are called flaky tests. These tests are a major problem because they can mislead developers to debug their recent code changes when the failures are unrelated to these changes. One prominent category of flaky tests is order-dependent (OD) tests, which can deterministically pass or fail depending on the order in which the set of tests are run. By detecting OD tests in advance, developers can fix these tests before they change their code. Due to the high cost required to explore all possible orders (n! permutations for n tests), prior work has developed tools that randomize orders to detect OD tests. Experiments have shown that randomization can detect many OD tests, and that most OD tests depend on just one other test to fail. However, there was no analysis of the probability that randomized orders detect OD tests. In this paper, we present the first such analysis and also present a simple change for sampling random test orders to increase the probability. We finally present a novel algorithm to systematically explore all consecutive pairs of tests, guaranteeing to detect all OD tests that depend on one other test, while running substantially fewer orders and tests than simply running all test pairs.
Digitalisierung – Status quo und ungenutzte Potenziale
Authors: Proff Harald , Ahrens Claudia , Neuroth Wencke , Proff Heike , Knobbe Florian , Szybisty Gregor , Sommer Stefan 
Published: March 2021

ZusammenfassungDieses Kapitel stellt Ziel und Aufbau des Buches vor.