bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury
Authors: Poudel Samikshya , Cabrera Diego Paine , Bhushan Bharat , Manley Michael W , Gunewardena Sumedha , Jaeschke Hartmut , Apte Udayan 
Published: September 2021

Abstract
Overdose of acetaminophen (APAP) is the major cause of acute liver failure (ALF) in the Western world with very limited treatment options. Previous studies from our groups and others have shown that timely activation of liver regeneration is a critical determinant of transplant-free survival of APAP-induced ALF patients. Here, we report that hepatocyte-specific deletion of Yes-associated protein (Yap), the downstream mediator of the Hippo Kinase signaling pathway results in faster recovery from APAP-induced acute liver injury. Initial studies performed with male C57BL/6J mice showed a rapid activation of Yap and its target genes within first 24 h after APAP administration. Treatment of hepatocyte-specific Yap knockout (Yap-KO) mice with 300 mg/kg APAP resulted in equal initial liver injury but a significantly accelerated recovery in Yap-KO mice. The recovery was accompanied by significantly rapid hepatocyte proliferation supported by faster activation of Wnt/β-catenin pathway. Furthermore, Yap-KO mice had significantly earlier and higher pro-regenerative inflammatory response following APAP overdose. Global gene expression analysis indicated that Yap-KO mice had a robust activation of transcription factors involved in response to endoplasmic reticulum stress (XBP1) and maintaining hepatocyte differentiation (HNF4α). In conclusion, these data indicate that inhibition of Yap in hepatocytes results in rapid recovery from APAP overdose due to an earlier activation of liver regeneration.
4Poetics
Authors: Dowling Sarah 
Published: September 2021

Abstract
This review examines three books published in the field of poetics in 2020: Candice Amich’s Precarious Forms: Performing Utopia in the Neoliberal Americas; Ren Ellis Neyra’s The Cry of the Senses: Listening to Latinx and Caribbean Poetics; and Anthony Reed’s Soundworks: Race, Sound, and Poetry in Production. I show that these three books, which discuss poetry in connection with other art forms, each call for a reordering of the senses through which we perceive and analyze poetry (and other texts). While Ellis Neyra advocates multisensorial listening and Reed calls for a mode of listening attentive to what remains unnamed within current perceptual and political schema, Amich shows the importance of paying attention to the embodied rhythms and tactility of poetry and performance texts. For all three authors, these alternatives to individualized, detached, and indeed deadened linguistic contemplation proffer strategies for remaking not only common sense, but the common itself. The chapter is structured under the following headings: 1. Introduction; 2. Poetics; 3. Sensoria; 4. Politics.
Molecular phylogeny, systematics and generic classification of the butterfly subfamily Trapezitinae (Lepidoptera: Papilionoidea: Hesperiidae)
Authors: Toussaint Fls Emmanuel F A , Braby Michael F , Müller Chris J , Petrie Edward A , Kawahara Akito Y 
Published: September 2021

Abstract
Trapezitinae skippers are restricted to Australia and New Guinea. Despite decades of taxonomic work, their systematics and phylogeny remain little understood. To resolve the composition of genera and determine their evolutionary relationships, we inferred a comprehensive multilocus molecular phylogeny of Trapezitinae. Our results recover a monophyletic Trapezitinae as sister to Barcinae, with a poorly resolved backbone possibly indicating an early rapid radiation. We recover two main clades comprising all currently described genera, including the previously contentious Prada Evans, 1949 but excluding Tiacellia Evans, 1949. Several genera are recovered as paraphyletic or polyphyletic, rendering the classification of Trapezitinae incompatible with the new phylogeny. Therefore, we synonymize Motasingha Watson, 1893 syn. nov. and Oreisplanus Waterhouse & Lyell, 1914 syn. nov. with Hesperilla Hewitson, 1868 and Neohesperilla Waterhouse & Lyell, 1914 syn. nov. with Toxidia Mabille, 1891. To reflect the placement of Anisynta dominula outside of Anisynta, we describe the new genus Atkinsia Braby & Toussaint gen. nov., which includes the sole species Atkinsia dominula (Plötz, 1884) comb. nov. Two species of Toxidia and two species of Signeta Waterhouse & Lyell, 1914 are placed into Timoconia Strand, 1909, yielding four new combinations: Timoconia melania (Waterhouse, 1903) comb. nov., Timoconia peron (Latreille, 1824) comb. nov., Timoconia flammeata (Butler, 1882) comb. nov. and Timoconia tymbophora (Meyrick & Lower, 1902) comb. nov. Thus, SignetaWaterhouse & Lyell, 1914 syn. nov. is now regarded as a junior synonym of Timoconia. Overall, our phylogeny has provided the basis for 20 nomenclatural changes at the species and subspecies level, including 14 new combinations.
Trimester-based changes in urogenital symptoms and their impact on the quality of life in pregnant women: A preliminary report
Authors: Uzelpasaci Esra , Çinar Gamze Nalan , Baran Emine , Gürşen Ceren , Nakip Gülbala , Ozgul Serap , Beksac Kemal , Unal Canan , Orgul Gokcen , Beksac Alp Tuna , Akbayrak Turkan , Beksac Mehmet Sinan 
Published: September 2021

Abstract

Background:
This study is aimed to determine the trimester-based changes in urogenital symptoms and their impact on the quality of life in pregnant women.

Materials and methods:
Fifty-one pregnant women participated in this study. Self-reported symptom-based questionnaires, Urogenital Distress Inventory-Short Form (UDI-6), Incontinence Severity Index (ISI), and Incontinence Impact Questionnaire (IIQ-7) were administered to determine urogenital symptoms, incontinence severity, and the quality of life in all participants in the first, second, and third trimesters. The findings obtained were analyzed with the Friedman and Spearman tests.

Results:
Irritative (urgency and frequency) and stress incontinence symptoms showed statistically significant changes (p < 0.05), whereas obstructive and genital pain/discomfort symptoms did not significantly change (p > 0.05) according to the scores of UDI-6 subscales over the trimesters. There were negative, weak-moderate correlations between stress incontinence symptoms and IIQ-7 in the first, second, and third trimester. There was a negative, moderate correlation between irritative symptoms and IIQ-7 only in the third trimester, but there were not any correlations between the other urogenital symptoms and IIQ-7 (p > 0.05). In the prepregnancy period, stress urinary incontinence (SUI) and urge urinary incontinence (UUI) occurred in 9.8% and 7.8% of the patients, respectively, whereas there were no women with mixed urinary incontinence (MUI) preconceptionally. The presence of SUI, UUI, and MUI were 13.7%, 7.8%, and 0% in the first, 26%, 9.8%, and 3.9% in the second, and 41.2%, 27.5%, and 13.7% in the third trimester, respectively. ISI scores showed statistically significant changes in the first, second, and third trimesters of women with SUI, UUI, and MUI (p < 0.05). Statistically significant differences were also found in UDI-6 and IIQ-7 scores obtained from all three trimester evaluations of pregnant women with SUI, UUI, and MUI (p < 0.05).

Conclusions:
Urogenital symptoms associated with urinary incontinence such as frequency, urgency, and stress incontinence were found to be increased over the course of the three trimesters of the pregnancy and the quality of life was negatively affected. Special care is essential for urinary incontinence during antenatal care.
Early Intervention Referral Information, Transmission, and Sources—A Survey of State Part C Coordinators and Analysis of Referral Forms
Authors: Sanders Benjamin W. , Zuckerman Katharine E. , Ash Joan S. , Kopstick Avi J. , Rivas Vazquez Luis , Gorman Paul N. 
Published: September 2021

ABSTRACT:

Objective:
Early Intervention (EI) referral is a key connector between health care and early childhood systems serving children with developmental risks. This study aimed to describe the US network of EI referrals by answering the following: “What information is sent to EI?”, “Who sends it?”, and “How is it sent?”

Method:
This study combined an analysis of national document-based and website-based referral forms with a survey of state Part C Coordinators (PCCs). Data on referral forms were systematically collected from state agency websites. PCCs from 52 jurisdictions were surveyed to assess current EI referral practices. Descriptive statistics were used for responses to multiple-choice items; free-text answers were condensed into key study themes.

Results:
EI referral forms came as e-documents (81%) or websites (35%), and 72% were in English alone. They emphasized family and referral source contact information and reason for the referral. The survey results indicated that health care (45%) sends the most referrals, followed by families (30%). EI agencies received referrals by phone (38%), electronically (23%), e-mail (17%), and fax (17%), and PCCs valued this diversity of methods. Few states received referral data directly from electronic health records (EHRs); however, PCCs hope to eventually receive referrals through websites, mobile devices, and EHRs.

Conclusion:
EI referral data flow is complex, with opportunities for loss of children to follow-up. This study describes how EI referrals occur and provides examples of how communication and access to information may be improved.
COVID-19 Vaccination and Asymptomatic Infection
Authors: Prato’ Simone , Paladino Maria Emilia , Riva Michele Augusto , Belingheri Michael 
Published: September 2021

Objective:To determine the incidence of COVID-19 and the duration of sick leave among asymptomatic healthcare workers (HCWs) after vaccination with BNT162b2.Methods:From October 2020 to March 2021, we determined the incidence of COVID-19 in a cohort of 671 asymptomatic HCWs before and after the vaccination. We also analyzed the days required to obtain a negative RT-PCR result after infection.Results:Prior to vaccination 105 (15.6%) HCWs were positive. Positive cases were reduced to 42 (7.5%) after the vaccination period (P < 0.0001). A negative RT-PCR was observed at the first control in 80% of vaccinated HCWs and only in 37% before vaccination.Conclusions:Even in case of asymptomatic infection, vaccinated HCWs have a reduced incidence and a shorter period of sick leave than before vaccination, suggesting vaccination impacts on the sustainability of the health system and labor costs.
Adapting clinical experiences during a pandemic: One college of nursing's approach
Authors: Makowski Andrew , Hampton Debra , Hardin-Pierce Melanie , Scott Leslie , Garritano Nicole , Tovar Elizabeth , Melander Sheila 
Published: September 2021

ABSTRACT
Graduate level nursing programs are having increasing difficulty obtaining clinical sites for their students. Nurse practitioner (NP) students need a minimum of 500 direct care hours in addition to indirect hours. Simulation experiences may not be used as direct patient care hours for NP students, but telehealth experiences may be used if the focus is on obtaining similar competencies to what would be acquired with face-to-face patient experiences. One college of nursing adapted several opportunities for NP students to acquire indirect clinical experiences and specific NP competencies during the coronavirus (COVID-19) pandemic. Several different clinically focused teaching methodologies were planned and implemented. These varied by NP specialty track and included complex case analyses, virtual (Zoom) rounds, well-child cases, and objective structured clinical examinations. These adapted clinical experiences are effective methods of helping students acquire clinical competencies and skills; however, they bring their own challenges. Post-COVID may be a time of new beginnings, moving nursing education forward on finding new and better ways to ensure that students acquire clinical competencies. What the new normal will be for nursing education is yet to be determined, but nursing education will likely never return to where we were before the pandemic.
Characterizing Differences in Thymic Function in Women With and Without Vulvodynia: A Community-Based Study
Authors: Willis Sydney K. , Aiello Allison E. , Chatterjea Devavani , Nelson Julie A. , Hibberd Patricia L. , Harlow Bernard L. 
Published: September 2021

Objective
The aim of the study was to evaluate the association between vulvodynia and thymic function.

Materials and Methods
In this case-control study of 200 clinically confirmed cases of vulvodynia and 205 general population controls residing in the Minneapolis/Saint Paul metropolitan area, we used DNA extracted from whole blood to measure levels of signal joint T-cell receptor excision circles (sjTRECs), a measure of thymic output. We used logistic regression to evaluate the association between vulvodynia and thymic function.

Results
In 405 participants (aged 18–40 years), we observed an association between decreasing thymic function and increasing age. Women with vulvodynia had a steeper decline in sjTREC values across age categories compared with women without vulvodynia. In addition, at younger ages, women with vulvodynia had higher sjTREC values compared with women without vulvodynia. In older women, those with vulvodynia had lower sjTREC than those without vulvodynia. When accounting for recency of vulvar pain onset, women with a shorter time since pain onset had higher thymic function compared with women with a longer time since vulvar pain onset.

Conclusions
These findings suggest that at younger ages, women with vulvodynia have higher thymic output and a more precipitous decline of thymic function than those without vulvodynia. It also seems that a strong immune inflammatory response is present proximate to the onset of vulvar pain and may wane subsequently over time.
Stigma Determines Antiretroviral Adherence in Adults With HIV in Myanmar
Authors: Aung Su , Hardy Nicole , Chrysanthopoulou Stavroula A. , Kyaw Aung , San Tun Min , Aung Khaymar Win , Rana Aadia , Kantor Rami 
Published: September 2021

Introduction:
Understanding social and structural barriers that determine antiretroviral therapy (ART) adherence can improve care. Assessment of such factors is limited in Myanmar, a country with high HIV prevalence and increasing number of people living with HIV initiating ART.

Methods:
Questionnaires were administered to adults with HIV across 4 Myanmar cities to estimate adherence and its potential determinants, including HIV knowledge, social support, barriers to care, enacted and internalized stigma, and engagement in peer-to-peer HIV counseling (PC). Associations were determined using logistic mixed-effects modeling.

Results:
Among 956 participants, the mean age was 39 years, 52% were female, 36% had CD4 <350 cells/mm3, and 50% received pre-ART PC. Good adherence was reported by 74% of participants who had better HIV knowledge than those reporting nonadherence. Among nonadherent, 44% were forgetful and 81% were careless about taking ART. Among all participants, most (53%) were very satisfied with their social support and 79% reported lack of financial resources as barriers to care. Participants most frequently reported being viewed differently by others (30%) and feeling as if they were paying for past karma or sins because of their HIV diagnosis (66%). Enacted stigma (odds ratio 0.86; 95% confidence interval 0.79 to 0.92, P < 0.01) and internalized stigma (odds ratio 0.73; 95% confidence interval: 0.56 to 0.95, P = 0.023) were associated with worse adherence.

Conclusions:
Increased self-reported ART adherence in Myanmar is associated with less enacted and internalized stigma. These findings suggest the benefit of developing and promoting adherence interventions, which are focused on mitigating HIV-related stigma in the county.
Diagnostic Performance of Lower Extremity Venous Wall Thickness and Laboratory Findings in the Diagnosis of the Behçet Disease
Authors: Tezcan Dilek , Özer Halil , Gülcemal Semral , Hakbilen Selda , Durmaz Mehmet Sedat , Batur Abdussamed , Yilmaz Sema 
Published: September 2021

Background/Objective
Behçet disease (BD) is not a single unique entity but a syndrome with different clinical phenotypes that can involve arterial and venous vessels of all sizes. To date, there has been no specific test or serum marker to measure and determine the severity of BD, and diagnosis remains based on clinical findings. This study aimed to assess lower extremity venous wall thickness (VWT) measured by ultrasound and laboratory findings and diagnostic performance in patients with BD.

Methods
A total of 106 participants were recruited from the rheumatology department in this single-center, case-control study. Participants meeting the eligibility criteria were divided into healthy controls (n = 52) and BD (n = 54). The VWT values of the common femoral vein, great saphenous vein, and popliteal vein were measured using ultrasonography. Laboratory data were obtained from the electronic registration database. Venous wall thicknesses and laboratory findings in patients with BD and healthy subjects were compared.

Results
Venous wall thickness of the lower extremity veins was higher in the BD group and higher in those with a history of deep vein thrombosis than in those without. The mean leukocyte, monocyte, erythrocyte sedimentation rate (ESR), C-reactive protein, plateletcrit (PCT), red cell distribution width (RDW), mean platelet volume (MPV) values, and monocyte-to-lymphocyte ratio (MLR) were higher in BD patients than in the control group. There was a correlation among increased VWT, ESR, PCT, MPV, RDW, and MLR.

Conclusions
C-reactive protein, ESR, MPV, PCT, MLR, RDW, and VWT can be used to assist in the diagnosis of BD.
A Good Aesthetic Outcome After Gross Total Tumor Resection in Combination With the Skull Reconstruction on Giant Epidermal Cyst Involving Both Intracranial and Extracranial Tissues
Authors: Shi Yifeng , Zhang Chenyang , Huang Hua , Hu Xin , Liu Yanhui 
Published: September 2021

Abstract
Epidermal or epidermoid cysts are 1 of the most frequent benign masses, they rarely grow to a huge size, and only a few cases have been reported. We report a rare case of a 52-year-old man with giant neoplasm growing invasively in the frontal region, including both intracranial and extracranial extensions, and caused extensive brain deformation and skull lesions. It is worth noting that the patient did not present any significant neurological symptoms and deficits for more than 40 years on admission. A combination of gross total tumor resection and cranioplasty was performed. The patient was satisfied with the results of the surgery, and no evidence of recurrence or complications were found in the 2 years follow-up. The authors reported the case not only to propose the first-stage aesthetic treatment option for this unusual mass on the scalp but also hinted at the vigilance and importance of systematic monitoring of the small skull mass for avoiding the potential risk of tumor progression, malignant transformation, operative trauma, and financial burden.
Clinical Value of Bilateral Balanced Frontotemporoparietal Decompressive Craniectomy in Severe Diffuse Traumatic Brain Injury
Authors: Wei ShengCheng 
Published: September 2021

Objective:
To explore the clinical value of bilateral balanced frontotemporoparietal decompressive craniectomy (bbDC) in severe diffuse traumatic brain injury by comparison to the unilateral frontotemporoparietal decompressive craniectomy (uDC).

Materials and Methods:
Twenty three patients with severe diffuse traumatic brain injury from April 2015 to December 2019 were selected, including 10 cases underwent bbDC (bilateral group) and 13 cases underwent uDC (unilateral group). Compared with the postsurgical intracranial pressure (ICP), cerebral perfusion pressure, cerebral blood flow volume, postsurgical imaging score, the occurrence of complications as well as the 6 month outcome (Glasgow Outcome Scale, GOS) of two groups.

Results:
1. The postsurgical ICP was lower in the bbDC group than in the uDC group, while the postsurgical CCP and cerebral blood flow volume were higher in the bbDC group than in the uDC group. 2. Postsurgical imaging scores of the bbDC group were lower, indicating that the decompression effect of bbDC was more exhaustive than that of the uDC group. 3. The incidence of intraoperative acute cerebral bulging was lower in bbDC group than in uDC group. 4. The bbDC could effectively reduce the proportion of patients with the worst prognosis (dead+vegetative state).

Conclusion:
For patients with severe, diffuse traumatic brain injury combined with bilateral or unilateral pupil dilation, bilateral balanced decompression craniotomy is an effective method, which should be performed as soon as possible. As compared to unilateral decompression, the decompression effect on the brainstem is more thorough; the incidence of acute cerebral bulging, postoperative incisional hernia, and postoperative cerebral infarction involving a large area are reduced. ICP can be better controlled, cerebral perfusion pressure and cerebral blood flow increases, improving the patient's survival rate, quality of life, and prognosis.
Mandibular Stability After Sagittal Split Ramus Osteotomy With Hybrid Technique in Asymmetric Patients
Authors: Lee Dong-Hun , Cho Sang-Ah , Jeon Ju-Hong 
Published: September 2021

Abstract
The hybrid technique after bilateral sagittal split ramus osteotomy is an internal fixation method using monocortical mini-plates and additional bicortical positional screws. In this study, we analyzed the postoperative stability of 23 patients with mandibular asymmetry who underwent bilateral sagittal split ramus osteotomy and hybrid fixation with or without LeFort I osteotomy. Anatomical landmarks of the deviated and non-deviated sides of the jaw were established to measure the angle and distance to the reference plane in three-dimensional cone beam computed tomography images. We analyzed the positional changes and correlations of the reference points at preoperative (T1), postoperative 2 weeks (T2), and postoperative 1 year (T3). There were significant differences in preoperative position of the upper and lower molar cervix alveolar crest to the reference plane (U6-X and L6-X) and the condylion angles between deviated and non-deviated sides. Postoperatively (T2–T3), each reference point had no statistically significant positional change. Pearson correlation coefficient between the amount of menton deviation (ME-X at T1) and positional change of menton after surgery (T2–T3) was 0.30, and P value was 0.168. The hybrid fixation technique is an effective fixation method for achieving postoperative stability for mandibular asymmetry.