bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAYA TERIMA DAN KANDUNGAN PROTEIN NUGGET KOMBINASI KACANG MERAH (Phaseolus Vulgaris. L) DAN HATI AYAM SEBAGAI PANGAN ALTERNATIF SUMBER PROTEIN UNTUK PENCEGAHAN STUNTING
Authors: Nandini Astri Puspa , Fajri Roifah , Yani Ahmad 
Published: February 2021

Latar belakang : Stunting menjadi salah satu permasalahan gizi di Indonesia. Prevalensi stunting di Indonesia sebesar 30.8% berdasarkan hasil pengukuran TB/U, hasil tersebut terdiri dari pendek 17.1% dan sangat pendek 12.8%. Pencegahan dapat dilakukan pada masa prakonsepsi dengan memperhatikan asupan protein, sumber protein salah satunya didapatkan dari kacang merah dan hati ayam.
Tujuan : Mengetahui perbedaan daya terima nugget dari berbagai rasio kacang merah dan hati ayam sebagai pangan alternatif sumber protein untuk pencegahan stunting dan mengetahui perbedaan kandungan protein nugget dari berbagai rasio kacang merah dan hati ayam sebagai pangan alternatif sumber protein untuk pencegahan stunting.
Metode : Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan tiga kali pengulangan, perbandingan kacang merah dan hati ayam yaitu, 90%:10%, 70%:30%, 50%:50%, 30%:70%, 10%:90%. Nugget akan diuji daya terima, selanjutnya hasil uji daya terima dilakukan dianalisis secara statistik menggunakan metode Kruskal Waliis dan Mann Whitney. Uji kandungan protein dilakukan dengan metode Kjeldahl dan hasilnya dianalisis secara statistik menggunakan metode One Way anova dan Duncan.
Hasil : Terdapat perbedaan daya terima aroma dan warna nugget dari berbagai rasio kacang merah dan hati ayam. Tidak terdapat perbedaan daya terima rasa dan tekstur nugget dari berbagai rasio kacang merah dan hati ayam. Terdapat perbedaan kandungan protein nugget dari berbagai rasio kacang merah dan hati ayam.
Simpulan : Hasil daya terima menunjukan nugget dengan perlakuan 90%:10%, 70%:30%, 50%:50% merupakan nugget yang disukai panelis. Kandungan protein tertinggi terdapat pada nugget dengan perlakuan 50%:50%.
PEMBUATAN SEDIAAN SERBUK INSTAN DAUN SIRSAK (Annona muricata L.) DIKOMBINASIKAN DENGAN SARI BUAH NANAS (Ananas comosus L.) UNTUK MENCEGAH PENINGKATAN KADAR ASAM URAT
Authors: Yuliani Suci Tri , Putra Risa Kota , Ratnasari Dewi 
Published: February 2021

Tujuan: Penelitian ini bertujuan untuk mengetahui cara pembuatan sediaan serbuk instan daun sirsak (Annona muricata L.) yang dikombinasikan dengan sari buah nanas (Ananas comosus L.) yang bermanfaat bagi kesehatan.
Metode: Penelitian ini menggunakan metode penelitian tindakan. Instrumen penelitian yang digunakan adalah lembar observasi dan kuisioner. Sediaan dibuat dengan perbandingan formulasi ektrak daun sirsak dan sari buah nanas (F1, 125ml:375ml; F2, 250ml:250ml dan F3, 375ml:125ml) dan masing-masingnya ditambahkan gula sebanyak 200gr.
Hasil: Penelitian menunjukkan formulasi sediaan serbuk instan yang berhasil dibuat dengan hasil terbaik yaitu formulasi F3 dengan perbandingan 375ml ekstrak daun sirsak, 125ml sari buah nans, dan 200gr gula. Pengamatan secara organoleptik sediaan serbuk instan stabil dalam penyimpanan selama tiga minggu.
Simpulan: Sediaan serbuk instan formulasi F3 sampel kedua lebih disukai dan diterima masyarakat karena warna yang lebih baik atas derajat suhu pemanasan pembuatan yang lebih tepat.
FORMULASI SEDIAAN GEL ANTISEPTIK DAUN SIRIH HIJAU (Piper betle linn) DENGAN BASIS BIJI RAMI (Linum usitatissimum) DAN PENAMBAHAN SARI JERUK NIPIS (Citrus x aurantiifolia) SEBAGAI AROMA
Authors: Bilqies Zalzabila Lusyana Fauziah , Andriani Susi , Yanto Elih Sutisna 
Published: February 2021

Latar Belakang: Sirih hijau mempunyai kelebihan daya antiseptik yang lebih dominan dibanding sirih lain, karena daya antiseptiknya yang kuat sering dimanfaatkan secara empiris untuk mengobati berbagai penyakit. Berkembangnya keinginan masyarakat untuk menggunakan bahan alam atau “back to nature”, ditanggapi dengan banyak produk-produk topikal berbahan aktif tanaman untuk perawatan kesehatan, kosmetik dan pencegahan penyakit. Piper batle Linn atau sirih hijau merupakan salah satu tanaman yang diketahui berkhasiat sebagai antiseptik. Penggunaan sirih hijau secara tradisional biasanya dengan merebus daun sirih kemudian air rebusan digunakan untuk kumur dan membersihkan bagian tubuh lain, atau daun sirih dilumatkan kemudian ditempelkan pada luka (Lindawaty, 2009).
Tujuan Penelitian: Penelitian ini bertujuan untuk membuat formulasi gel antiseptik yang berbasis biji rami dan ditambahkan dengan sari buah jeruk nipis sebagai aromatik, membuat gel antiseptik yang stabil dan homogen serta mengetahui pH yang di uji pada suhu ruang dan memiliki bentuk, warna, dan bau yang baik.
Metode: Penelitian ini menggunakan desain penelitian tindakan (action research) desain penelitian tindakan ini bertujuan untuk mengidentifikasi dan menemukan solusi dari sebuah masalah yang diteliti. Pada penelitian ini menggunakan 4 siklus antara komponen penting, seperti perencanaan, tindakan, pengamatan, dan refleksi. Perencanaan penelitian ini berupa tahapan-tahapan perencanaan kerja yang harus dilakukan pada saat penelitian, lalu dilanjutkan dengan penelitian dan pengamatan hasil dari penelitian kemudian dianalisis sebagai refleksi terhadap ketercapaian peneliti pada saat penelitian.
Hasil: Hasil susut pengeringan dari simplisia yg digunakan yaitu daun sirih sebesar 73,4 % berdasarkan uji stabilitas pH mengalami kenaikan pada sediaan, sediaan homogen, dan bertahan selama 20 hari.
Simpulan: Simpulan dari penelitian ini yaitu stabilitas fisik sediaan formula II dan III dapat bertahan selama 20 hari pada penyimpanan suhu kamar (15-30oC) dengan pH awal 4 dan pH akhir 6, kuning kecoklatan, bau khas jeruk nipis dan sirih, tekstur licin. Pada suhu dingin (± 4oC), formula II dan III dapat bertahan selama 21 hari.
Daptomycin Pharmacokinetics in Adolescents Undergoing Hemodialysis and Peritoneal Dialysis: A Case Series With Pharmacokinetic Modeling
Authors: Lim Sin Yin , Lewis Teresa , Woo Sukyung , Turman Martin , Bourne David W. A. , Burton Michael E. , Rianthavorn Pornpimol 
Published: February 2021

BACKGROUNDChildren who undergo hemodialysis (HD) and peritoneal dialysis are at increased risk of infection. Daptomcyin is used to treat resistant infections; however, the pharmacokinetics of daptomycin in pediatric and adolescent dialysis patients remain unknown.METHODSWe report the safety and pharmacokinetics of a single intravenous 5 mg/kg dose of daptomycin for 6 individuals age 12 to 17 years old who underwent HD or continuous cycling peritoneal dialysis (CCPD). Daptomycin concentrations from all samples were determined by high-performance liquid chromatography. A non-compartmental analysis was performed to compare the pharmacokinetic parameters among HD and CCPD patients. A population pharmacokinetic model was developed to describe the concentration-time profiles of daptomycin in plasma, urine, and dialysis effluent. Monte Carlo simulations were performed to assess the pharmacodynamic outcomes.RESULTSAll subjects tolerated the single dose of daptomycin. During HD, significant drug removal was observed, compared with CCPD (26% vs 5% of total dose). A low daptomycin renal clearance (&lt;12% of total clearance) with moderate variability (40.5%) was observed among subjects with residual renal function. An anuric and obese subject who received CCPD treatment appeared to have &gt;80% higher daptomycin area under the plasma concentration-time curve than the other CCPD subjects. Dosing regimens that achieved predefined pharmacodynamic targets were reported.CONCLUSIONSDaptomycin clearance was faster in 12- to 17-year-old patients receiving HD than CCPD. Administration of daptomycin immediately after HD reduces drug loss. The CCPD treatment, anuria, and obesity may increase the risk for drug accumulation. Our pharmacokinetic model can be further used to optimize dosing regimens of daptomycin in this population.
Coenseignement orthopédagogue-enseignante et orthopédagogue-enseignant : l’expérience de trois écoles primaires montréalaises
Authors: Dubé France , Cloutier Émilie , Dufour France , Paviel Marie-Jocya 
Published: February 2021

Au Québec, la réussite éducative des élèves en contexte de diversité implique une mobilisation croissante de l’ensemble des personnes oeuvrant en milieux scolaires et des changements dans l’organisation des services éducatifs. Dans ce contexte, les modèles de services s’appuyant sur la collaboration professionnelle, comme les modèles de coenseignement, proposent de nouvelles avenues afin de répondre aux besoins de tous les élèves, notamment au primaire. La présente recherche avait pour but de soutenir et de décrire les pratiques de coenseignement mises en oeuvre par des orthopédagogues et des enseignantes et enseignants.Des facilitateurs et des obstacles au coenseignement ont également émergé, et des pistes ont été proposées afin de permettre à d’autres écoles d’expérimenter le coenseignement orthopédagogue-enseignante et orthopédagogue-enseignant dans le futur. Le partage d’expertise professionnelle complémentaire, le respect mutuel ainsi que le temps accordé à la coplanification, à la concertation et à la rétroaction sont à privilégier pour que ce type de coenseignement soit réussi. Les orthopédagogues sont ainsi amenés à élargir leurs pratiques et à modéliser des stratégies enseignées à tous les élèves d’un groupe-classe.
Le coenseignement : bénéfices, limites et importance de la formation
Authors: Janin Myriam , Couvert David 
Published: February 2021

Dans le système scolaire français, l’inclusion d’élèves à besoins éducatifs particuliers dans les classes ordinaires du second degré est en augmentation. Cela a engendré le développement de coenseignement entre les personnels de l’enseignement régulier et de l’enseignement spécialisé. L’objectif de cet article est d’étudier les ressentis de chacun quant aux effets du coenseignement, et d’analyser l’impact d’une formation associée à sa mise en oeuvre. L’approche choisie s’appuie sur une enquête adressée à une cohorte composée de personnels enseignants réguliers et spécialisés ayant (ou non) bénéficié d’une formation spécifique. Les réponses sont traitées, d’une part, de façon statistique et, d’autre part, par une analyse qualitative. Il en ressort que les bénéfices constatés sont supérieurs aux difficultés induites par la pratique. Les résultats indiquent que le coenseignement aurait permis aux personnels enseignants de 1) gagner en compétence dans leur champ d’expertise, 2) diversifier leurs compétences, et 3) augmenter leur sentiment d’efficacité personnelle par les effets positifs constatés sur les élèves. Ces bénéfices perçus sont majorés par le fait d’avoir suivi une formation spécifique. La principale difficulté énoncée est celle du temps commun nécessaire à la préparation des séances. Globalement, les personnels interrogés adhèrent à la pratique malgré certaines difficultés et souhaitent la pérenniser.
Science Fiction
Authors: Vint Sherryl 
Published: February 2021

How science fiction has been a tool for understanding and living through rapid technological change.
The world today seems to be slipping into a science fiction future. We have phones that speak to us, cars that drive themselves, and connected devices that communicate with each other in languages we don't understand. Depending on the news of the day, we inhabit either a technological utopia or a Brave New World nightmare. This volume in the MIT Press Essential Knowledge series surveys the uses of science fiction. It focuses on what is at the core of all definitions of science fiction: a vision of the world made otherwise and what possibilities might flow from such otherness.
After a brief overview of the genre's origins, science fiction authority Sherryl Vint considers how and why contemporary science fiction is changing. She explores anxieties in current science fiction over such key sites of technological innovation as artificial intelligence, genomic research and commodified biomedicine, and climate change. Connecting science fiction with speculative design and futurology in the corporate world, she argues that science fiction does not merely reflect these trends, but has a role in directing them.
Ketamine
Authors: Moghaddam Bita 
Published: February 2021

The emergence of ketamine—previously known as a combat anesthetic and club drug—as a treatment for depression.
Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depression, has been touted by scientists and media reports as something approaching a miracle cure. This volume in the MIT Press Essential Knowledge series chronicles the ascent of a drug that has been around for fifty years—in previous incarnations, a Vietnam-era combat anesthetic and a popular club drug—that has now been reinvented as a treatment for depression. Bita Moghaddam, a leading researcher in neuropharmacology, explains the scientific history and the biology of ketamine, its clinical use, and its recently discovered antidepressant properties, for the nonspecialist reader.
Despite the excitement, Moghaddam points out, concerns exist over the unknown long-term effects of the drug; the FDA assigned ketamine a “black box” warning—its most serious safety warning. Moghaddam describes the discovery of ketamine, how it was tested on humans, and how it is used as an anesthetic, club drug, and research tool. She explains ketamine's effects on brain receptors and neurotransmitters; its emergence as an antidepressant; and theories about its antidepressant properties. Finally, she reviews safety concerns and considers future directions for research, discussing whether what we learn about ketamine will change the way we understand and treat psychiatric disorders.
Determining novel candidate anti-hepatocellular carcinoma drugs using interaction networks and molecular docking between drug targets and natural compounds of SiNiSan
Authors: Zhang Qin , Feng Zhangying , Gao Mengxi , Guo Liru 
Published: February 2021

Background
SiNiSan (SNS) is an ancient traditional Chinese medicine (TCM) used to treat liver and spleen deficiencies. We studied the unique advantages of using SNS to treat hepatocellular carcinoma (HCC) with multiple components and targets to determine its potential mechanism of action.

Methods
The active compounds from the individual herbs in the SNS formula and their targets were mined from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). HCC-associated targets were collected from the TCGA and GEO databases and samples were collected from patients with stage III hepatocellular carcinoma. A compound-disease target network was constructed, visualized, and analyzed using Cytoscape software. We built a protein-protein interaction (PPI) network using the String database. We enriched and analyzed key targets using GSEA, GO, and KEGG in order to explore their functions. Autodock software was used to simulate the process of SNS molecules acting on HCC targets.

Results
A total of 113 candidate compounds were taken from SNS, and 64 of the same targets were chosen from HCC and SNS. The predominant targets genes were PTGS2, ESR1, CHEK1, CCNA2, NOS2 and AR; kaempferol and quercetin from SNS were the principal ingredients in HCC treatment. The compounds may work against HCC due to a cellular response to steroid hormones and histone phosphorylation. The P53 signaling pathway was significantly enriched in the gene set GSEA enrichment analysis and differential gene KEGG enrichment analysis.

Conclusions
Our results showed that the SNS component has a large number of stage III HCC targets. Among the targets, the sex hormone receptors, the AR and ESR1 genes, are the core targets of SNS component and the most active proteins in the PPI network. In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.
Delving Into the Visual System in the AMA Guides, Fifth Edition
Authors: Schainholz Daniel C. 
Published: February 2021

Abstract
The assessment of visual impairment using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, requires a thoughtful ophthalmologic evaluation and careful application of the functional vision tests and arithmetic criteria provided in Chapter 12, The Visual System, and other chapters, as applicable. The interpolation of the multiple dimensions of the visual system into the enumeration of a single impairment percentage may involve complex mathematical manipulations. Properly enumerated, the value can be utilized rigorously in impairment evaluations, functional evaluations, and even for academic research.
Advanced absorber heat integration via heat exchange packings
Authors: Moore Thomas , Nguyen Du , Iyer Jaisree , Roy Pratanu , Stolaroff Joshuah K. 
Published: February 2021

AbstractA rate‐based model of an absorption column was developed and used to analyze several intercooling strategies utilizing “heat exchange packings.” These packings are capable of removing heat from the column and transferring it to a cooling fluid within the packing. For absorption of CO2into aqueous monoethanolamine under industrial conditions, intercooling via heat exchange packings placed along 10–20% of the column could reduce the column height by ∼15%. The height of these columns was close to the minimum theoretical value, calculated by numerically optimizing the temperature profile. Effective intercooling could also be achieved by using the cool, rich solvent as the cooling fluid. This reduces the cooling load and facilitates recovery of waste heat. Heat exchange packings could also be used to redistribute heat within the column, reducing the column height with no net cooling load. However, this approach requires larger heat transfer coefficients than have been experimentally observed.
BIM in der Instandsetzungsplanung
Authors: Bornholdt Marike , Petersen Matthias , Goedeke Holle 
Published: February 2021

AbstractDer vorliegende Beitrag befasst sich mit der Nutzung der BIM‐Software Desite von thinkproject in der Instandsetzungsplanung von Bestandsbauwerken. Anhand aktueller Projekte des Ingenieurbüros WTM Engineers wird die Art und Weise der Softwarenutzung in verschiedenen Phasen der Planung erläutert, um die Digitalisierung von Instandsetzungsprojekten voranzutreiben. In der Instandsetzungsplanung beginnt BIM mit der dreidimensionalen Modellierung des Bestands. Im weiteren Projektverlauf ist im Zusammenhang mit der Schadensaufnahme im Bestand und der Planung und Durchführung von Bauteil‐ und Baustoffuntersuchungen eine eindeutige Platzierung und Attribuierung von Objekten im Modell notwendig. Um die strukturierten Daten aus der BIM‐Software an andere Projektbeteiligte weiterzugeben, steht ein verlustfreier Datenaustausch über allgemeingültige Dateiformate im Vordergrund. Das bezieht sich auch auf den Austausch von Informationen zwischen unterschiedlichen Softwareanwendungen in Bezug auf Terminplanungen und Kostenkalkulationen. Anhand von ersten Erfahrungen in diesem Bereich wird ein Ausblick über die Möglichkeiten einer BIM‐basierten Instandsetzungsplanung gegeben.
Development of photoluminescent, superhydrophobic, and electrically conductive cotton fibres
Authors: Alzahrani Hanan K. , Munshi Alaa M. , Aldawsari Afrah M. , Keshk Ali A. , Asghar Basim H. , Osman Hanan E. , Khalifa Mohamed E. , El‐Metwaly Nashwa M. 
Published: February 2021

AbstractA simple method for the preparation of multifunctional nanocomposite was developed towards the production of water‐repellent, electrically conductive, and photoluminescent film onto cotton fibres. The nanocomposite was composed of lanthanide‐doped strontium aluminium oxide and silicon rubber dispersed in petroleum ether. The electrically conductive fabric was woven from nickel strips twisted with cotton filaments as core yarns, which were wrapped with pure cotton yarns. The nanoparticles (NPs) of lanthanide‐doped strontium aluminium oxide were mixed with environmentally friendly room‐temperature vulcanizing silicon rubber (RTV‐SR) dissolved in petroleum ether to give the silicon rubber/strontium aluminate nanocomposites. The produced nanocomposites were applied onto electrically conductive cotton/nickel fibres using spray‐coating technology. The surface of the cotton/nickel fibres showed different hierarchical morphologies depending on the total content of the silicon rubber. Additionally, the superhydrophobic effect was found to be improved upon increasing the total content of the luminescence pigment NPs. The morphologies of the prepared phosphor NPs were determined using transmission electron microscopy (TEM). The generated transparent luminescence film demonstrated an absorbance peak at 358 nm and an emission peak at 515 nm. Photoluminescence of cotton fibres was monitored with the generation of different colours, including grey, green‐yellow, bright white, and turquoise shades as recognized using CIE Laboratory colorimetric parameters. The emission, excitation, lifetime, and decay time spectra of the phosphorescent spray‐coated cotton samples were studied. The surface morphologies and chemical compositions of the spray‐coated cotton/nickel were investigated using wavelength‐dispersive X‐ray fluorescence (WD‐XRF), scanning electron microscope (SEM), Fourier‐transform infrared spectra (FTIR), and energy‐dispersive X‐ray analyzer (EDAX). The superhydrophobic effects were characterized by measuring static water contact angle. The comfort characteristics of the treated cotton/nickel substrates were assessed by investigating their air permeability and stiffness. The treated cotton/nickel fabrics also displayed an antimicrobial activity. The results displayed water repellence with high electrical conductivity and photoluminescence properties.
Quantifying the spatial distribution of sediment transport in an experimental gully system using the morphological method
Authors: Dai Wen , Xiong Liyang , Antoniazza Gilles , Tang Guoan , Lane Stuart N. 
Published: February 2021

AbstractWhilst time‐series of sediment transport in gullies in both laboratory experimental and field settings can be determined through instrumentation, quantifying the spatial distribution of transport rates remains challenging. The morphological method, which was proposed for estimating bed‐material transport in both one‐ and two‐dimensions in rivers, provides an alternative. Here, we developed this method for gully systems. A laboratory catchment was used to simulate gully erosion. High‐resolution topographical data were acquired by close‐range digital photogrammetry. Morphological changes were determined using high‐resolution topographic data and an associated level of detection. Based on measured morphological changes, one‐dimensional (1D) and two‐dimensional (2D) sediment transport rates were calculated via cross‐section by cross‐section routing (1D) and cell by cell routing (2D). The 1D application provided a general trend of longitudinal variation of sediment transport for the whole gully system, increased gradually from zones of headward extension to a zone downstream where erosion and deposition were in balance, and sediment transport rates less variable in space. For the 2D application, hydrological and blended hydrological‐hydraulic routing solutions were compared. We found that the level of negative transport was insensitive to whether or not a blended hydrological‐hydraulic routing was used and that results from applying the hydrological routing throughout were not significantly degraded. We also found that consideration should be given to spatial and temporal resolution of the topographic data. The 2D application provided spatial patterns of sediment transport that vary with gully evolution. The main gully remained a high transport corridor but branch transport became more important through time. The framework we report provides an additional tool for both experimental and field quantification of the spatial patterns of sediment transport in gullies; and quantification of how these patterns change under different forcing factors.