bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gobernanza hídrica como securitización socioambiental en la subcuenca La Sabana–Tres Palos, Acapulco
Authors: Galán Castro Erick Alfonso , Rodríguez Herrera América Libertad , Rosas-Acevedo José Luis 
Published: March 2021

*Full article is in SpanishEnglish Abstract:
This article analyzes three types of water governance in the sub-basin of La Sabana River–Tres Palos Lagoon from the perspective of Michel Foucault’s governmentality. These processes—including the board of directors of the Metropolitan Water Operator Organism called the Drinking Water and Sewage Commission of the Municipality of Acapulco (CAPAMA), the Basin Council of the La Sabana River–Laguna de Tres Palos Lagoon, and an experience in community water management in the town of Kilómetro 30, in the same municipality of Acapulco—are addressed through analysis based on the following question: How is the relationship between citizens and officials for water management in the Acapulco region governed? The actors perceive a greater tendency for political control than democratization in decision-making.Spanish Abstract:
Este artículo analiza tres tipos de gobernanza del agua en la subcuenca del Río La Sabana–Laguna de tres Palos desde la pers pectiva de la gubernamentalidad de Michel Foucault. Estos procesos—el Consejo de Administración del Organismo Operador de Agua metropolitano denominado Comisión de Agua Potable y Alcantarillado del Municipio de Acapulco (CAPAMA), el Consejo de Cuenca del Río La Sabana–Laguna de Tres Palos, y una experiencia de gestión comunitaria de agua en la localidad de Kilómetro 30, del mismo municipio de Acapulco—son observados mediante la pregunta: ¿Cómo se gubernamentaliza la relación entre ciudadanos y funcionarios para la gestión del agua en esa región? Los actores perciben una mayor tendencia al control político que a la democratización en la toma de decisiones.French Abstract:
Cet article analyse trois types de gouvernance de l’eau dans le sous-bassin de la rivière La Sabana-Laguna de tres Palos du point de vue de la gouvernementalité de Michel Foucault. Ces instances -le conseil d’administration de l’organisme métropolitain de l’exploitant de l’eau appelé Commission de l’eau potable et des égouts de la municipalité d’Acapulco (CAPAMA), le conseil du bassin du Río la Sabana-Laguna de Tres Palos, et une expérience dans la gestion communautaire de l’eau dans la localité du Kilometro 30, dans la même municipalité d’Acapulco-, sont observées à partir de la question suivante: comment la relation entre les citoyens et les responsables de la gestion de l’eau est-elle gouvernementalisée dans cette région? Il en ressort qu’en ce qui concerne la prise de décision, les acteurs perçoivent davantage une tendance au contrôle politique qu’à la démocratisation.
KONSTRUKSI PUNGUTAN LIAR PADA PENYELENGGARA PENDIDIKAN DASAR
Authors: Mulyadi Dedi 
Published: March 2021

Bantuan Oprasional Sekolah (BOS) merupakan program Pemerintah untuk menyukseskan pendidikan wajib belajar 9 tahun, yang dibiayai oleh Program Konpensasi Pengurangan Subsidi Bahan Bakar Minyak (PKPSBBM), namun meskipun adanya Bantuan Oprasional Sekolah (BOS). Implementasi pelaksanaan penyelenggaraan pendidikan seperti sekarang ini, tidak akan terlepas dari permasalahan yang muncul, yang salah satunya permasalahan tentang pungutan liar
Metode penelitian yang digunakan adalah penelitian hukum normatif yang bersifat deskriptif analisis, pengumpulan data dilakukan dengan menggunakan data primer dan data sekunder berupa bahan hukum primer, sekunder dan tertier sebagai data utama. Setelah data sekunder dan primer terkumpul, kemudian diadakan analisis secara kualitatif
Berdasarkan hasil analisis data, disimpulkan bahwa konstruksi pungutan pendidikan pada dasarnya dibuat kepala sekolah dan komite sekolah. Pungutan liar pada penyelenggara pendidikan dasar dengan berbagai modus operandinya sudah menjadi rahasia umum bagi masyarakat dan hal ini sulit dicegah karena melibatkan stakeholders pada lembaga tersebut. Padahal Pungutan liar bertentangan dengan Pasal 9 ayat (1) Peraturan Menteri Pendidikan Dan Kebudayaan No 44 tahun 2012 tentang Pungutan Dan Sumbangan Biaya Pendidikan Pada Satuan Dasar dan Terjadinya pungutan liar tentu ada penyebabnya, faktor penyebab pungli secara umum dapat diklasifikasikan menjadi dua macam, yaitu faktor internal dan faktor eksternal.
ANALISIS K3 SEKSI CASTING DENGAN PENDEKATAN TEKNIK FTA DAN JSA AGAR MEMINIMUMKAN TINGKAT RISIKO KECELAKAAN DALAM KERJA
Authors: Bastuti Sofian 
Published: March 2021

PT. Surya Toto Indonesia, Tbk merupakan sebuah perushaan produsen produk peralata da perlegkapan kebutuhan Plumbing Fitting yang cukup besar di Asia Tenggara. Berbagai proses produksinya dengan mesin dan mempunyai potensi bahya dari beberapa proses salah satunya proses Casting 2 adalah proses pencetakkan atau pengecoran logam untuk membentuk desain untuk menghasilkan part dan produk fitting. Jumlah kecelakaan kerja di PT. Surya Toto Indonesia, Tbk dari Tahun 2010 sampai dengan Tahun 2016 total ada 19 kasus kecekakaan di daam pabrik. Sehingga diperlukannya untuk mengukur tingkat risiko kecelakaan kerja agar bisa menurunkan tingkat kecelakaan kerja, khususnya di seksi Casting 2 dengan pedekatan teknik Job Safety Analysis (JSA) dan Fault Tree Analysis (FTA) untuk menurunkan tingkat risiko kecelakaan kerja di PT. Surya Toto Indonesia, Tbk. Setelah dilakukan tindakan perbaikan maka nilai tingkat risiko pada pekerjaan proses memotong di mesin cutting, sebelum perbaikan adalah 450 (very hight), dan sesudah dilakukan tindakan perbaikan maka di dapat nilai risiko tersebut adalah 90 (substansial).
PENGARUH CORPORATE GOVERNANCE DAN KINERJA PERUSAHAAN TERHADAP KETEPATAN WAKTU PENYAMPAIAN LAPORAN KEUANGAN BAGI PERUSAHAAN GO PUBLIC
Authors: Andarsari Pipit Rosita 
Published: March 2021

This study aims to determine the effect of the board of commissioners, audit committees, profitability ratios, leverage ratios, and liquidity ratios on the timely delivery of financial statements. In this study the commissioner variable is proxied by the size of the board members, the audit committee is proxied by the size of the audit committee member, profitability ratio is proxied by ROA, leverage ratio is proxied by DER, and liquidity ratio is proxied by CR. The research sample the basic and chemical sectors listed on the Indonesia Stock Exchange in 2016-2017 using a purposive sampling method. Research data sources secondary. Data analysis techniques logistic regression analysis. The results that the board of commissioners, audit committee, profitability ratio (ROA), and leverage ratio (DER) had no significant effect while the liquidity ratio (CR) had a significant effect on the timeliness of financial statement submission.
Keyword : board of commissioners, audit committee, profitability ratio (ROA), leverage ratio (DER) , leverage ratio (DER)
Towards a definition of anti-oppressive dietetic practice in Canada
Authors: Ng Eric , Wai Caroline 
Published: March 2021

Increasingly, dietitians have found ourselves working with racialized clients, communities, and colleagues across the health and food systems in Canada. We are often asked to treat the adverse health outcomes of Black, Indigenous, and racialized communities resulting from these oppressions at the individual level. However, it is the role of dietitians to engage in efforts to "reduce health inequities and protect human rights; promote fairness and equitable treatment" (College of Dietitians of Ontario, 2019). An anti-oppression approach is required for dietitians to understand how their power and privilege shape the dietitian-client relationship. The purpose of this commentary is to propose a shift from cultural competence or diversity and inclusion in dietetics to an explicit intention of anti-oppressive dietetic practice. We begin our exploration from the Canadian context. We draw from our background working in health equity in public health, and our experiences facilitating equity training using anti-oppression approaches with dietetic learners and other public health practitioners. In creating a working definition of anti-oppressive dietetic practice, we conducted a scan of anti-oppression statements by health and social services organizations in Ontario, Canada, and literature from critical dietetics. A literature search revealed anti-oppressive practice frameworks in nursing and social work. However, this language is lacking in mainstream dietetic practice, with anti-oppression only discussed within the literature on critical dietetics and social justice. We propose that "dietitians can engage in anti-oppressive practice by providing food and nutrition care/planning/service to clients while simultaneously seeking to transform health and social systems towards social justice."
Características morfológicas, melhoramento genético e densidade de plantio das culturas do sorgo e do milho: uma revisão
Authors: Silva Davi Francisco da , Garcia Pedro Henrique de Melo , Santos Girlene Cordeiro de Lima , Farias Iasmin Myrele Santos Calaça de , Pádua Guilherme Vinicius Gonçalves de , Pereira Pedro Henrique Borba , Silva Francisco Edson da , Batista Regiane Farias , Gonzaga Neto Severino , Cabral Ana Maria Duarte 
Published: March 2021

Nesse estudo, objetivou-se realizar uma breve revisão sobre características morfológicas, melhoramento genético e densidade de plantio das culturas do sorgo (Sorghum bicolor L.) e do milho (Zea mays L.). A busca da literatura incluída no estudo foi conduzida por meio de uma pesquisa eletrônica nas bases de dados Google Scholar, Scientific Electronic Library Online (SciELO), na web e em sites da Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA. Como critério de inclusão, se considerou bibliografias que tratassem de temas relacionados a morfologia, genética e densidades de plantio do milho e do sorgo. Os critérios de exclusão das bibliografias foram: estudos fora do objetivo do estudo e que não contemplaram o período e idioma estabelecido da pesquisa. De modo geral, o milho e o sorgo são gramíneas que contribuem diretamente com a cadeia produtiva e com o agronegócio, em decorrência da sua importância nutricional em sistemas de produção animal. As suas caraterísticas botânicas, morfológicas e fenológicas, permitem que essas culturas apresentem boa produtividade e adaptabilidade em diferentes regiões do Brasil (Sul, Região Central e Nordeste). A capacidade de adaptação do milho e do sorgo às distintas condições edafoclimáticas, dependem do potencial genético da semente e do sistema de plantio empregado, bem como, da competência do tipo de genótipo em suportar até certo ponto altas densidades populacionais. Sugere-se a condução de estudos que avaliem individualmente os atributos morfológicos e fenológicos de distintas variedades do milho e do sorgo e suas habilidades de adaptação e produção em diferentes densidades de plantio.
Aplikasi Bacillus sp Pada Produksi Enzim Menggunakan Metode Fermentasi Padat - Review
Authors: Maftukhah Siti 
Published: March 2021

Solid State Fermentation (SSF) atau fermentasi padat dianggap sebagai metode fermentasi yang paling menguntungkan dari pada Submerged Fermentation (SmF) atau fermentasi terendam. Hal ini dikarenakan bahwa metode fermentasi padat (SS) lebih ramah lingkungan, produktivitas fermentasi yang lebih tinggi, konsentrasi produk dan stabilitas yang lebih tinggi, penekanan katabolik yang lebih rendah, penanaman mikroorganisme khusus untuk substrat yang tidak larut dan juga aktifitas sterilitas yang lebih rendah karena aktivitas air yang digunakan sangat rendah. Bacillus sp dapat digunakan untuk produksi enzim. Makalah ini mengulas aplikasi fermentasi padat (SSF) untuk produksi enzim yaitu amilase, esterase, xilanase, pektinase dan likenase oleh Bacillus sp. Dalam produksi enzim yang menggunakan Bacillus sp adalah Bacillus cereus yang menghasilkan enzim amilase, Bacillus sp. JB-99 yang menghasilkan enzim xilanase, Bacillus licheniformis yang menghasilkan enzim likenase, Bacillus altitudinis AP-MSU yang menghasilkan enzim esterase, Bacillus sp. DT7 menghasilkan enzim pektinase, dan banyak Bacillus sp dengan proses fermentasi padat yang menghasilkan enzim.
Revisiting the Relationship Between Alzheimer’s Disease and Cancer With a circRNA Perspective
Authors: Chen Danze , Hao Shijia , Xu Jianzhen 
Published: March 2021

BackgroundIncreasing evidence indicates an association between the incidence of Alzheimer’s disease (AD) and cancer development. Despite advances being made by comparisons from epidemiological studies, common pathways and molecular mechanisms, little is known about the identities of the circular RNAs (circRNAs) involved in the development and progression of these two pathologies and their possible correlations. The aim of this study was to explore the circRNA relationship between AD and cancer.Materials and MethodsIn this investigation, circRNAs that were significantly dysregulated in AD or associated with AD diagnosis, clinical dementia severity, and neuropathological severity, were examined in a large panel of 28 cancer types. On the basis of shared abnormal circRNAs in AD and cancers, we constructed a circRNA-micro RNA (miRNA)-messenger RNA (mRNA) network by leveraging experimentally identified miRNA-circRNA and miRNA-mRNA interactions from crosslinking-immunoprecipitation sequencing data.ResultsAn inverse correlation of expression pattern was found in acute myeloid leukemia, juvenile myelomonocytic leukemia, renal cell carcinoma, and myelofibrosis. CircRNAs associated with AD diagnosis and clinical severity demonstrated negative correlation in more cancer types. Notably, differentially expressed candidate circRNAs in temporal lobe epilepsy were not associated with any cancers. Gene Ontology and KEGG pathway analysis suggested the circRNA-regulated genes are significantly associated with interleukin-12-mediated signaling and viral response. CircPICALM, circRTN4 and circMAN2A1 are the hub nodes in the circRNA-miRNA-target network.ConclusionOur results indicated the relevance of inflammation signaling as a common pathogenesis shared by cancer and AD and provided novel insight for therapeutics targeting circRNAs.
Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Pulmonary Infectious Pathogens From Bronchoalveolar Lavage Samples
Authors: Chen Yuqian , Feng Wei , Ye Kai , Guo Li , Xia Han , Guan Yuanlin , Chai Limin , Shi Wenhua , Zhai Cui , Wang Jian , Yan Xin , Wang Qingting , Zhang Qianqian , Li Cong , Liu Pengtao , Li Manxiang 
Published: March 2021

BackgroundMetagenomic next-generation sequencing (mNGS) is a powerful method for pathogen detection. In this study, we assessed the value of mNGS for bronchoalveolar lavage (BAL) samples in the diagnosis of pulmonary infections.MethodsFrom February 2018 to April 2019, BAL samples were collected from 235 patients with suspected pulmonary infections. mNGS and microbial culture were performed to evaluate the effectiveness of mNGS in pulmonary infection diagnosis.ResultsWe employed mNGS to evaluate the alpha diversity, results suggesting that patients with confirmed pathogens had a lower microbial diversity index compared to that of patients with uncertain pathogens. For the patients admitted to the respiratory intensive care unit (RICU) or on a ventilator, they experienced a lower diversity index than that of the patients in the general ward or not on a ventilator. In addition, mNGS of BAL had a diagnostic sensitivity of 88.89% and a specificity of 14.86% in pulmonary infection, with 21.16% positive predictive value (PPV) and 83.87% negative predictive value (NPV). When rare pathogens were excluded, the sensitivity of mNGS decreased to 73.33%, and the specificity increased to 41.71%. For patients in the simple pulmonary infection group and the immunocompromised group, the main infection types were bacterial infection (58.33%) and mixed-infection (43.18%). Furthermore, mNGS had an advantage over culture in describing polymicrobial ecosystem, demonstrating the microbial distribution and the dominant strains of the respiratory tract in patients with different underlying diseases.ConclusionsThe study indicated that mNGS of BAL samples could provide more accurate diagnostic information in pulmonary infections and demonstrate the changes of respiratory microbiome in different underlying diseases. This method might play an important role in the clinical use of antimicrobial agents in the future.
Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent
Authors: Shirley Debbie-Ann , Sharma Ishrya , Warren Cirle A. , Moonah Shannon 
Published: March 2021

Parasitic infections contribute significantly to worldwide morbidity and mortality. Antibiotic treatment is essential for managing patients infected with these parasites since control is otherwise challenging and there are no vaccines available for prevention. However, new antimicrobial therapies are urgently needed as significant problems exist with current treatments such as drug resistance, limited options, poor efficacy, as well as toxicity. This situation is made worse by the challenges of drug discovery and development which is costly especially for non-profitable infectious diseases, time-consuming, and risky with a high failure rate. Drug repurposing which involves finding new use for existing drugs may help to more rapidly identify therapeutic candidates while drastically cutting costs of drug research and development. In this perspective article, we discuss the importance of drug repurposing, review disulfiram pharmacology, and highlight emerging data that supports repurposing disulfiram as an anti-parasitic, exemplified by the major diarrhea-causing parasiteEntamoeba histolytica.
Case Report: Pheochromocytoma in a 59-Year-Old Woman Presenting With Hypotension
Authors: Wu Hao-Yu , Gao Tian-Jiao , Cao Yi-Wei , Liang Lei 
Published: March 2021

Background: Pheochromocytoma patients who present with shock are extremely rare. Here, we report a patient who presented with shock and was diagnosed with pheochromocytoma.Case Summary: A 59-year-old woman with a history of hypertension without any treatment for 5 years presented with chest tightness. Vital signs on arrival indicated blood pressure of 78/50 mmHg. Twelve-lead electrocardiogram indicated ST-segment depression in leads II, III, aVF, and V3–V6 and QT prolongation. Coronary angiogram revealed no evidence of coronary artery disease. Contrast-enhanced computed tomography demonstrated an inhomogeneous right adrenal mass (2.5 × 3.0 cm). Her 24-h urinary norepinephrine and catecholamine levels were elevated. The patient underwent laparoscopic right adrenalectomy. Histopathology confirmed adrenal pheochromocytoma with residual necrosis. The patient was diagnosed with pheochromocytoma. During the 2-year follow-up, the patient was asymptomatic, and her blood pressure remained normal without medication. ECG showed that the ST-segment depression in leads II, III, aVF, and V3–V6 and the QT prolongation had disappeared. The patient showed no signs of recurrence, with normal urine norepinephrine and catecholamine levels.Conclusion: Patients with pheochromocytoma can present with hypotension or even shock. Clinicians should suspect pheochromocytoma when a patient with a history of hypertension has sudden hypotension or even shock.
Risk of Clinically Relevant Venous Thromboembolism in Critically Ill Patients With COVID-19: A Systematic Review and Meta-Analysis
Authors: Gratz Johannes , Wiegele Marion , Maleczek Mathias , Herkner Harald , Schöchl Herbert , Chwala Eva , Knöbl Paul , Schaden Eva 
Published: March 2021

Background: Early during the course of the ongoing COVID-19 pandemic, reports suggested alarmingly high incidences for thromboembolic events in critically ill patients with COVID-19. However, the clinical relevance of these events was not reported in several studies. Additionally, more recent research showed contradictory results and suggested substantially lower rates of venous thromboembolism. Thus, the aim of the present study was to summarize evidence on the incidence of clinically relevant venous thromboembolism (VTE)—defined as VTE excluding isolated subsegmental pulmonary embolism (PE) and distal deep vein thrombosis (DVT)—in adult critically ill patients with COVID-19.Methods: We performed a systematic review of studies reporting the incidence of clinically relevant PE and/or DVT in critically ill patients with COVID-19. Scientific reports published in the English language between January and October 2020 were included. We conducted a random-effects model meta-analysis to calculate incidence estimates of clinically relevant VTE and bleeding events. We also performed exploratory meta-regression and subgroup analyses of different diagnostic approaches and additional factors that possibly influenced the incidence of these outcomes.Results: Fifty-four articles (5,400 patients) fulfilled the predefined inclusion criteria, of which 41 had a high risk of bias. The majority of included patients were male, &gt; 60 years, and overweight. Twenty-one studies reported the use of prophylactic doses of heparin. Pooled incidences for clinically relevant PE were estimated at 8% (95% CI, 4–11%), for proximal DVT at 14% (95% CI, 9–20%), and—after exclusion of studies with a high risk of bias—for the composite outcome of VTE at 18% (95% CI, 13–24%). Clinically relevant bleeding occurred at a rate of 6% (95% CI, 2–9%).Conclusions: We summarized currently available data on the rate of clinically relevant VTE in critically ill patients with COVID-19. Pooled incidence estimates were lower than those reported by previous review articles. In the absence of evidence-based anticoagulation guidelines for critically ill patients with COVID-19, the results of our study provide clinically important information for an individual risk-benefit assessment in this context.Registration: The study protocol was prospectively registered in PROSPERO on June 22, 2020 (CRD42020193353; https://www.crd.york.ac.uk/prospero).
Identification of a Risk Stratification Model to Predict Overall Survival and Surgical Benefit in Clear Cell Renal Cell Carcinoma With Distant Metastasis
Authors: Chen Jiasheng , Cao Nailong , Li Shouchun , Wang Ying 
Published: March 2021

Background: Clear cell renal cell carcinoma (ccRCC) is the main subtype of renal cell carcinoma and has different prognoses, especially in patients with metastasis. Here, we aimed to establish a novel model to predict overall survival (OS) and surgical benefit of ccRCC patients with distant metastasis.Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) databases, we identified 2185 ccRCC patients with distant metastasis diagnosed from 2010 to 2015. Univariate and multivariate Cox analysis were used to identify significant prognostic clinicopathological variables. By integrating these variables, a prognostic nomogram was constructed and evaluated using C-indexes and calibration curves. The discriminative ability of the nomogram was measured by analyses of receiver operating characteristic (ROC) curve. A risk stratification model was built according to each patient's total scores. Kaplan-Meier curves were performed in the low-, intermediate- and high-risk groups to evaluate the survival benefit of surgery.Results: Eight clinicopathological variables were included as independent prognostic factors in the nomogram: grade, marital status, T stage, N stage, bone metastasis, brain metastasis, liver metastasis, and lung metastasis. The nomogram had a better discriminative ability for predicting OS than Tumor-Node-Metastasis (TNM) stage. The C-index was 0.71 (95% CI 0.68–0.74) in the training cohort. The calibration plots demonstrated that the nomogram-based predictive outcomes had good consistency with the actual prognosis results. Total nephrectomy improved prognosis in both the low-risk and intermediate-risk groups, but partial nephrectomy could only benefit the low-risk group.Conclusions: We constructed a predictive nomogram and risk stratification model to evaluate prognosis in ccRCC patients with distant metastasis, which was valuable for prognostic stratification and making therapeutic decisions.