bluuebunny/crossref_metadata_2025_split huggingface dataset:
Privacy Preservation, Trust, and Security in Intelligent Embedded Systems
Authors: Yadav Kusum , Alharbi Yasser 
Published: October 2021

Abstract
An embedded system is a software and hardware system that is based on a microcontroller or microprocessor designed to accomplish the dedicated functions within a massive electrical or mechanical system. An intelligent embedded system (IES) is a generation or promising evolution of an embedded system (ES). IES has the ability of reasoning about their external atmosphere and acclimates their nature accordingly. The capacity of IES is characterized by the ability of process, service, or product to expose the performance of the environment to enrich the lifetime, quality, and satisfaction of the individual. IES facilitates the processing of information gathered from the embedded sensors. IES rely on numerous multidisciplinary methods for the successive operation.IES is widely employed in consumer electronics, industrial machines, agriculture, medical equipment, and other automated applications. It is programmable and necessary functionalities can be achieved effectively. In this article diversified utilities of embedded intelligence, challenges, issues, privacy, and security metrics of IES are discussed.
Analysis of Strawberry Metabolic Profiling in Interaction with Bacillus Spp. Strain DM12 using Gas Chromatography-Mass Spectrometry and Determination of Its Antifungal Activity
Authors: Alijani Zahra , Amini Jahanshir , Mozafari Ali akbar 
Published: October 2021

Abstract
An endophytic bacterial strain, isolated from Fragaria × ananassa, and antifungal properties against Colletotrichum nymphaeae was assayed under in vitro, in vivo, and greenhouse experiments. Bacterial strain was identified as Bacillus spp. DM12 (MH161581) using phenotypic, biochemical and molecular phylogenetic analysis of the 16S rDNA gene. DM12 strain inhibited mycelial growth of fungal pathogen (64.03%) using dual-culture test. The cell-free culture compounds produced by DM12 prevented mycelial growth and conidial germination of C. nymphaeae by 32.86% and 73.98%, respectively but, inhibition percentage of mycelial growth of pathogen by volatile compounds was less (9.82%). As well as, protease, chitinase, pectinase, siderophore, IAA, gibberellin, and phosphate solubilization tests for this strain were positive. Anthracnose disease at post-harvest on fruit suppressed by the strain DM12 (90.87%). Also, biocontrol efficacy on strawberry plants by drenching soil and spraying methods were 72.22% and 94.44%, respectively, 60 days after inoculation. PCR amplification represented the presence of genes of surfactin. In addition, metabolite profile of strawberry was changed on presence of bacterial strain that a number of metabolites in control treatment with maximum area percent were Acetoglyceride (19.418%), Acetic acid, butyl ester (4.734%) and Ribitol (4.349%), in treatment inoculated with DM12 strain alone were Tetramethyl-2-hexadecen (21.350%), Ethylene glycol monoisobutyl ether (18.688%) and Myrtenol (8.75%), in treatment inoculated with fungal pathogen alone were Acetoglyceride (18.089%) and Acetic acid, monoglyceride (17.96%) and in treatment inoculated with C. nymphaeae and DM12 strain together were tert-Butanethiol (36.153%), Ethoxytriethylsilane (14.126%), 5-(Methylamino)-1,2,3,4-thiatriazole (9.53%) and 2,3-Butanediol (7.795%).
Sustaining 99.99% Reliability for US Electric Grid by using Renewable Energy Systems Complexity as a Benefit
Authors: Mechtenberg Abigail , Francois Henri , Stratman Anne , Stiller Robert , McLaughlin Brady , Frink-Larca Desere ́e , Brown Janaya 
Published: October 2021

Abstract
Renewable energy system designers in status-quo and high-income countries (HICs) work to improve the environmental and societal impacts of energy systems by using increasingly complex technologies to predict the future. However, low-to-middle-income countries (LMICs) focus on innovative solutions by turning complexity into an asset. This paper presents the results from four optimization objectives, presented as scenarios with data from EIA utility regions, and with powerloads scaled using population data, solar radiance, wind speed, and wastewater treatment plant (WWTP) capabilities for biogas turbines. This allowed for the complexity of renewable energy systems to be used as a benefit instead of a deficit. For many US cities, an emerging LMIC-based optimization pathway can make possible energy system designs that increase reliability by including backup biogas generators. Here we show that the HIC-based approach is optimal for some cities; for others the status-quo pathway; for many, surprisingly, the LMIC approach is optimal.
Cheminformatics and Pharmacological Network Analysis for the Prediction of Molecular Mechanism of Herbal Drug Ligands
Authors: Singh Lalit Raj 
Published: October 2021

Abstract
The global demand for safer and more therapeutically effective medications is surging, providing medicinal plants a boost as suppliers of lead particles. The focus of current research is on an in silico comparison of one major bioactive principle and curatively designed new small drug-like molecule (scaffold analog). The recent study confirmed that the plant belongs to the Cyperaceae family and that it is Cyperus rotundus L. in taxonomy. The study's purpose was to uncover the mechanism of action of ligands/ scaffold analog by revealing genomic relationships, cellular signaling, and the top ten diseases/ illnesses that they were linked to. The scaffold analog showed promising drug-like potential as compared with cyperene. These investigations could broaden the reach of herbal medications, provide new formulations for current diseases or disorders, and pave the door for drug repurposing.
Crocodile tear syndrome post microvascular decompression of the trigeminal nerve: a case report and literature review
Authors: Abul Mohammad H 
Published: October 2021

Abstract
Background Crocodile tear syndrome (CTS) is a condition characterised by excessive tear secretion in response to eating, drinking, or smelling foods. Traditionally, acquired cases are most commonly reported following facial nerve trauma or paralysis, or in slow-growing facial nerve tumours. More recently, it has been reported following vestibular Schwannoma surgery. We report the first case of crocodile tear syndrome following microvascular decompression of the trigeminal nerve. Case presentation A 61-year-old lady presented with excessive lacrimation and clear rhinorrhoea one month post-operatively from a re-do trigeminal microvascular decompression surgery. The patient experienced similar symptoms following her initial surgery two years prior, which had resolved spontaneously. CT and MRI head, and comprehensive clinical examination showed no evidence of CSF rhinorrhoea or cause of her symptoms. An ENT opinion was sought, and the patient was diagnosed with post-operative crocodile tear syndrome.Literature review revealed no reported cases of CTS following microvascular decompression of the trigeminal nerve. Surgical technique and relevant imaging were reviewed for any possible explanation for the condition. Considering the accepted pathogenesis of CTS, we discuss the aetio-pathogenesis for the development of the condition following this procedure. Conclusions We conclude CTS should be considered in patients presenting with rhinorrhoea following microvascular decompression of the trigeminal nerve. In patients presenting with post-operative rhinorrhoea after MVD, after excluding CSF leak, CTS should be considered as a potential differential diagnosis. Treatment for CTS in this context may pose a challenge. The patient has undergone botulinum toxin injection of the lacrimal gland and will need long term follow up. This is the first documented case of CTS post microvascular decompression of the trigeminal nerve.
Interoperable System for COVID-19
Authors: Chaudhari Yash , Sachdeva Shelly , Aggarwal Lakshita 
Published: October 2021

Abstract
In the year 2020, the world halted due to the spread of COVID-19 or SARS-CoV2 which was first identified in Wuhan, China. Since then, it has caused a plethora of problems around the globe such as the loss of millions of lives. India was one of the countries which were majorly affected by this pandemic. Thousands lost their lives and millions had to be hospitalized and taken into medical care. Due to this, there is an abundance of unorganized and redundant medical data in the Health Information Technology sector. Many hospitals contain various mismatched health records of a single person. We attempt to develop an Interoperable System specifically for COVID-19 using the openEHR standard to organize health records in digital form by creating Electronic Health Records. These records can be accessed and shared by multiple hospitals and clinics to reduce the redundancy of health records. This would establish effective communications between different hospitals and greatly make data sharing, efficient and low cost. Standardization can hugely affect medical errors. Interoperability provides hospitals to share across many channels and help Health care workers to detect discrepancies easily. Lives that are lost due to human error in the health care system can be minimized or even completely avoided. The number of hospitals using interoperable standards is still low and we hope that this paper will help make a change towards following the standard.
Analysis of structural differences of Ag Nanoparticles generated using Thermal and E-beam process based on SEM image
Authors: Saha Mainak , Singh Simrat , Acharjee Suvojit , Kandagatla Chandrasekhar , Chakrabartty Shubhro 
Published: October 2021

Abstract
The variation in applications of nanoparticles (NPs) comes from differences in their microstructures. This may be observed in the terms of variation in size, area fraction and even the morphology of the particles. It is mainly the size and topography of these particles which govern the mechanical, and optoelectronic properties and have a huge impact in Bio-medical engineering.
Assessing the homogeneity of Actimask® acetaminophen and N-acetyl glucosamine mixture to predict further steps in the development of orodispersible tablets
Authors: Zupanets Ihor , Ruban Оlena , Kolisnyk Tetiana , Stolper Yurij 
Published: October 2021

One of the main problems in the production of tablets, which has significant negative consequences, is the segregation of the tablet mixture leading to inhomogeneity of dosage units, material losses in the manufacturing process and improperness of the specified pharmaceutical technical characteristics of the mixture.
The aim of the research. This work aims at the pharmaceutical technical study of the substances N-acetyl-D-glucosamine and Actimask® Acetaminophen and determination the uniformity of the powder mixture of active pharmaceutical ingredients (APIs) to predict the optimal technology for obtaining a pharmaceutical formulation with the acceptable properties.
Materials and methods. N-acetyl-D-glucosamine (Zhejiang Candorly Pharmaceutical, China) and Actimask® Acetaminophen (SpiPharma, USA) were used.
Scanning probe microscope Solver P47N-PRO ("NT-MDT", Russia), optical microscope, flowability tester VP-12A, laser diffraction particle size analyzer SALD-2201 ("Shimadzu", Japan), liquid chromatograph Agilent 1260 Infinity II with Diode Array Detector (Agilent Technologies, USA), spectrophotometers Shimadzu UV-1800 ("Shimadzu", Japan) were used.
The study of API pharmaceutical technical properties (microscopic characteristics, moisture absorption capacity, flowability, bulk volume and tapped volume, particle size distribution by sieve analysis and laser diffraction), as well as vibration simulation and following chromatographic study were carried out in this work.
Results and discussion. The shape of the particles N-acetyl-D-glucosamine and Actimask® Acetaminophen, which was determined by microscopic analysis, demonstrated the possibility of N-acetyl-D-glucosamine particles to stick to Actimask® Acetaminophen ones. The experimental study allowed to reveal the hygroscopicity of both APIs; poor flowability, unsatisfactory Hausner ratio, and Carr index for N-acetyl-D-glucosamine; excellent flowability, Hausner ratio, and Carr index for Actimask®. Vibration caused segregation of the powder mixture. It was found that all layers do not meet the requirements and an excessive content of Actimask® is registered, which indicates the stratification of the powder mixture.
Conclusions. The physical properties of the substances were determined and found to have significant differences in their particle size distribution. Segregation of the mixture after vibration was confirmed by laser diffraction and assay analysis. In order to solve the segregation problem, the granulation of N-acetyl-D-glucosamine may be proposed.
Female patients with androgenetic alopecia: immunohistochemical picture of scalp biopsies
Authors: Salyenkova Olena 
Published: October 2021

The aim of the research. To expand the knowledge about immunohistochemical changes in female patients with androgenetic alopecia (AGA) focusing on non-androgenic co-factors of pathogenesis of the disease, as this may serve as a basis for improving therapeutic regimens.
Materials and methods. Scalp biopsies of female patients with androgenetic alopecia were examined by immunohistochemical method. The study included two groups: the main group of 30 female patients aged 22 to 40 years, average age 32,13±5,03 years, and the control group that included 20 skin samples from women aged 25–40 years (average age 34,75±4,19 years) who underwent autopsies.
Results. It was found that AGA in women is characterized by a number of immunomorphological manifestations: the inflammatory infiltrate that consists of immunocompetent T-lymphocytes CD3+, CD4+ and CD8+, macrophages (CD68+); imbalance of growth polypeptides VEGF, TGF-β1, EGFR; accumulation of oxidative stress enzymes eNOS and iNOS; accumulation of pathological fraction of Collagen IV.
Conclusions. The data obtained by this study helps to improve the concept of morphogenesis of AGA, and also can become a base to improve the standards of treatment of the disease. The pathological triade “oxidative stress-microinflammation- fibrosis” should be considered as a possible treatment target, as well as the imbalance of growth peptides.
Screening and monitoring of watermelon source material by components of the vegetation period in the conditions of the forest-steppe of Ukraine
Authors: Linnik Zahar , Sergienko Oksana , Harbovska Tetiana 
Published: October 2021

Relevant in the selection of each crop, including watermelon is a comprehensive study of the source material to identify sources of valuable traits and include them in the selection process in order to expand the genetic diversity of the culture. According to the results of research, to create a new source material for heterosis selection of watermelon, screening and monitoring of the vegetation period duration (number of days from germination to ripening) and its components 118 (101 varieties, 17 hybrids) genotypes of watermelon in the forest-steppe of Ukraine have been conducted. Research methods are generally accepted: field experiment, observation, accounting, analysis, statistical. According to the results of determining the duration of the components of the vegetation period, the samples were divided into five groups of ripeness: early (65–80 days) – 80 (68 %), medium-early (81–85 days) – 14 (12 %), medium (86–95 days) – 18 (15 %), medium-late (96–105 days) – 4 (3 %) and late (106 days) – 2 (2 %). Variety-samples, selected by morphological and economically valuable characteristics, belong mainly (80 %) to early and medium-early. Only 6 % of genotypes belong to the medium-late and late-ripening groups. 52 samples with the smallest separate interphase periods were isolated. According to the results of the research, 8 sources with the high early ripeness were identified, the vegetation period of which was 66–70 days: Yellow early 108105 (66 days), Karapuz 108109, Surprise 108121 (67 days), Gift of the sun 108109, Lezheboka honey 108116, Thailand №1 108153 ( 69 days), Sweet Diamond 107874, Northern Lights 108127 (70 days). Sources are involved in the selection process
Essential Oils and Alcohol Extracts of Northwest Tunisia M. communis
and M. spicata: Phytocompounds, Antioxidant and Antibacterial Activities
Authors: Medjeldi Saida , Benrachou Nora , Bouchelaghem Sabrina , Jallouli Sélim , Farès Nadia , Elkahoui Salem 
Published: October 2021

Background:
Nowadays, the conventional chemical compounds used in
the food, pharmaceutical, and cosmetic sectors have proven to be less efficient from an economic
and health point of view. Research has therefore focused on the isolation of bioactive molecules
from plants or microorganisms.

Objective:
The study focused on the leaf’s volatile compounds determination from Myrtus communis
(McEOs) and Mentha spicata (MsEOs) as well as the evaluation of phytochemical fractions
and biological activities from their methanol extracts (McME and MsME).

Methods:
Phenolic compounds analysis revealed interesting concentrations of total phenols,
flavonoids, and condensed tannins. The antibacterial activity tested on seven pathogenic bacteria
has to be effectuated by the gel diffusion method. The extracts showed much better DPPH radical
scavenging activity than the volatile compounds. The McEOs and MsEOs profiles analyzed by
CG-MS showed a mixture of several compounds with a predominance of 1,8-Cineole (48.1%) and
α-pinene (39.02%) in the case of McEOs. In the case of MsEOs, the predominant compounds were
D-Carvone (78.79%), dihydrocarvone (6.16%), and 1.8 Cineole (2.33%).

Results:
It emerges from this study that the M. communis and M. spicata leaves, rich in phenolic
and terpenic compounds, constitute a promising source of diversified biological activities and
can be used in agro-food, cosmetic, and pharmaceutical sectors.
Comparative lactic acid bacteria (LAB) profiles during dadih fermentation with spontaneous and back-slopping methods, as identified by terminal-restriction fragment length polymorphism (T-RFLP)
Authors: Wirawati Chandra Utami , Sudarwanto Mirnawati Bachrum , Lukman Denny Widaya , Wientarsih Ietje , Srihanto Eko Agus 
Published: October 2021

The diversity of lactic acid bacteria (LAB) present during the manufacture of traditional fermented buffalo milk from West Sumatra, known as dadih, was studied via a culture-independent approach using terminal-restriction fragment length polymorphism (T-RFLP) to compare the dynamic diversity in back-slopping and spontaneous fermentation methods. Total LAB and pH were measured in freshly prepared buffalo milk and in \textit{dadih} fermented for 24 and 48 hours. The results indicated significant differences between the fermentation methods, with higher total LAB, and greater phylotype richness and relative abundance being identified in the back-slopping method. Terminal fragment lengths (TRFs) of 68 and 310 bp were common to both techniques, similar to those of Lactobacillus fermentum, Fructobacillus pseudoficulneus, Leuconostoc citreum, Leuconostoc kimchii, and Leuconostoc sp. The changes in phylotype number (species number) and relative abundances of LAB communities identified are expected to produce data needed to formulate the best fermentation process for dadih manufacturing. A 24-hour back-slopping fermentation method is recommended, as fermentation time of longer than 24 hours reduced viable LAB significantly. Our results also indicated that the T-RFLP technique is not only clearly sensitive enough and adequate for segregating LAB diversity in both fermentation methods, but that it also provides good information regarding the structure of microbial communities and their composition change during the fermentation process.
Unfolded protein response in rice (Oryza sativa L.) varieties with different level of salt stress tolerance
Authors: Ramadhan Galang Rizki , Avivi Sholeh , Sugiharto Bambang , Fanata Wahyu Indra Duwi 
Published: October 2021

Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure. In this study, we examined the relationship between the degree of salt tolerance and unfolded protein response-related gene expression in India salt-tolerant Pokkali and INPARI 35 varieties compared to the Indica salt-sensitive counterpart IR64 and INPARI 4 varieties. Our result showed that the salt tolerance of Pokkali and INPARI 35 had been confirmed by their higher survival rate, higher chlorophyll content, lower electrolyte leakage, and lower H2O2 and malondialdehyde content under salt stress conditions. Furthermore, the expression of unfolded protein response genes was highest in INPARI 35, whereas IR64 and INPARI 4 exhibited low gene induction during endoplasmic reticulum stress conditions. Among the four examined varieties the salt tolerant Pokkali surprisingly showed the lowest induction of all examined unfolded protein response-related genes. These results indicated the possibility that unfolded protein response supports the rice plant for adapting to the saline environment.
Tipologi batas wilayah administrasi untuk memudahkan pengelolaan batas daerah di Indonesia
Authors: Hidayat Fahrul , Munawaroh Munawaroh , Rachma Tia Rizka Nuzula 
Published: October 2021

Abstrak Terhitung sejak 1945 – 2017, baru sekitar 48% dari 977 segmen batas daerah di Indonesia yang disahkan melalui Peraturan Menteri Dalam Negeri tentang batas daerah. Pengelolaan batas wilayah daerah sangat penting untuk berbagai urusan pembangunan misalnya pengelolaan sumber daya alam. Oleh karena itu, penelitian ini mengusulkan pendekatan baru untuk mendukung pengelolaan batas wilayah yang efisien yaitu melalui segmentasi berbasis tipologi batas wilayah. Tahapan analisis meliputi: membandingkan, memotong, dan mengelompokkan garis batas. Single Buffer Overlay Method digunakan untuk membandingkan unsur geografis pada Peta Rupabumi Indonesia (data referensi) dan garis batas 2017 (data yang diuji). Selanjutnya, dilakukan pemotongan garis sesuai hasil perbandingan. Pada akhirnya, garis tersebut dikelaskan berdasarkan tipologinya (igir, jalan, dan sungai) menggunakan metode SQL (Structured Query Language). Hasil penelitian menunjukkan bahwa mayoritas (41,8%) batas daerah di Indonesia tidak menggunakan unsur geografis tertentu sebagai penanda batasnya, sedangkan persentase penanda batas berupa sungai 35,9%, igir 16,4%, dan jalan 5,8%. Abstract Since 1945 – 2017, only 48% of 977 regional borderlines of Indonesia were legalized by The Ministry of Home Affairs. Properly managed intra-national boundaries are fundamental for development purposes e.g. natural resource management. Therefore, this research proposed a new approach to help managing the boundary efficiently through typology-based borderlines segmentation which was conducted by some stages: compare, split, and classify lines. Single Buffer Overlay Method used for comparison purpose by utilizing some geographical features on a topographic map as a referenced dataset and boundary line (2017 database) as a tested dataset. Then we split the lines based on the comparison result. Finally, each split line was classified into border typologies (road, ridge, and stream) by using the SQL (Structured Query Language) method. We found that most of The Indonesian administrative boundary segments (41.8%) did not use a geographical feature, while the boundary on the rivers 35.9%, ridges 16.4%, and roads 5.8%.