bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and characteristics of cancer patients with COVID-19: a meta-analysis study
Authors: Sitanggang Johan S. , Siregar Kamal B. , Sitanggang Henry H. , Sprinse Vinolina Noverita 
Published: September 2021

Background: Cancer patients are considered susceptible to coronavirus disease (COVID-19) due to an immunosuppressive state. This study determined the prevalence of cancer in COVID-19 patients, severe events, case fatality rate, history of anticancer therapy associated with severe events, and type of cancer in cancer patients with COVID-19 in the world. Methods: This study used a meta-analysis study approach, sourcing studies from various countries related to cancer and COVID-19. Inclusion and exclusion criteria were established to select studies. A PRISMA flowchart was presented to assess the selection process. Data from inclusion studies were analyzed using Review Manager 5.4. Results: The prevalence of cancer in COVID-19 patients was 4.63% (95% CI, 3.78-5.49%) worldwide. The lowest prevalence was the Asian study group with 2.36% (95% CI, 1.86-2.87%) and the highest prevalence was the European study group with 10.93% (95% CI, 6.62-15.24%). About 43.26% (95% CI, 34.71-51.80%) of cancer patients with COVID-19 experienced severe events of COVID-19. In total, 58.13% (95% CI, 42.79-73.48%) of cancer patients with COVID-19 who in the last month had a history of anticancer therapy experienced severe events. The prevalence of lung cancer in cancer patients with COVID-19 was 20.23% (95% CI, 7.67-32.78%). Forest plots are also presented related to the results of meta-analysis research. Conclusions: High prevalence of cancer among COVID-19 patients indicates the susceptibility of cancer patients to SARS-CoV-2 infection. Cancer in COVID-19 patients and use of anticancer therapy increase severe events of COVID-19.
Failure Risk Model of Sustainable Solid Waste Management at The University in Indonesia using Dynamic System Approach
Authors: Rimantho Dino , Hidayah Nur Yulianti , Herzanita Ayu , Sandi Anggina 
Published: September 2021

Background - One of the problems encountered by all universities in realizing a sustainable Green Campus is solid waste management due to its complex and dynamic nature, which is known to have the potential risks of failure. Aim – Application of a dynamic modeling approach with the FMEA and AHP methods to eliminate the risk associated with the inability of universities to process solid waste. Methods– Data on risk factors and alternative evaluation methods were collected from five experts from various fields. Results – The results of the risk assessment by experts show some of the highest risk values are associated with Technological Infrastructure, with a risk value of around 900, and the lowest risk is associated with Regulation collisions with a risk value of around 378. The results provided adequate information on the increased risk of each factor from 2019 to 2030 with verified moderate and optimistic conditions models comprising significant values of approximately 0.009 and 0.0273, respectively. This study assists higher education management in decreasing risk failure in the region by creating simulation models that will likely be utilized for scenario analysis in the future. The System Dynamic model's entire approach proved helpful in accomplishing long-term solid waste management in universities. Other dynamic insights that assisted universities improve their knowledge of solid waste management systems. Research limitations– Further study needs to be conducted in the dynamic model to obtain a more comprehensive and detailed result. This is because the developed model provided an overview that needs further improvement, especially concerning several quantitative data, towards obtaining the adequate method for sustainable solid waste management. Originality/value – This research used the hybrid method and AHP techniques to analyze solid waste in universities which were developed into a dynamic system model. However, further research is needed to enhance this hybrid method.
Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study
Authors: Saeed Hager Moustafa , Mohammad Amr Eman , Rezk Lotfy Rezk Alshaimaa , Abd Elmoneim Wesam 
Published: September 2021

Background: Several systemic diseases manifest themselves in the oral cavity. Oral manifestations of lupus erythematosus (LE) are associated with a significantly increased risk of cancer. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: A descriptive study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr EL Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Moreover, patients’ medical records were also evaluated. The oral manifestations were recorded according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in LE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. 74.3% of the patients had oral candidiasis. The prevalence of skin lesions in LE patients was 37.6%. The most common finding was malar rash 79%. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with LE as the WHO considers oral manifestations of LE a widespread state associated with an increased risk of cancer. Also, implementation of oral hygiene measures and treatment to improve patients’ nutritional state and health-related quality of life are recommended.
A long way to go: engagement of men and boys in country family planning commitments and implementation plans
Authors: Hook Christopher , Hardee Karen , Shand Tim , Jordan Sandra , Greene Margaret E. 
Published: September 2021

Background: To reach global goals related to women and girls’ access to modern family planning (FP) and gender equality, evidence shows that it is critical to understand and account for the role of men and boys as users of reproductive health services, as partners for millions of women & girls around the world, and as advocates in their communities. Under the Family Planning 2020 (FP2020) partnership, countries were encouraged to develop costed implementation plans and action plans in an effort to provide 120 million additional women and girls with contraception. As FP2020 becomes FP2030, reviewing these previously-developed strategies helps understand the extent to which countries considered the engagement of men as an important aspect of their family planning portfolios. Methods: We conducted textual analysis on commitments and implementation plans related to achieving FP2020 commitments in six countries in Africa and one in Asia to determine the extent to which male engagement was incorporated into country or subnational family planning goals, with particular focus on FP policy, program, and financial commitments. Results: Some of the documents analyzed included robust plans for including male engagement in their efforts to expand access to FP. The strongest aspects of male engagement programming were those that sought to engage men as advocates for women’s access to and use of FP services, and improve their knowledge and attitudes related to contraception and reproduction. The weakest aspects were engaging men as users of services and, vitally, tackling underlying gender norms which hamper men’s and women’s health-seeking behaviors and attitudes. Conclusions: Developing FP programs that target men and boys as people deserving of reproductive health services, as partners with women in building their families, and as social activists in their communities, will complement and strengthen existing FP programs as well as promote broader goals related to gender equality.
COVID-19 vs. stakeholder engagement: the impact of coronavirus containment measures on stakeholder involvement in European energy research projects
Authors: Süsser Diana , Ceglarz Andrzej , Stavrakas Vassilis , Lilliestam Johan 
Published: September 2021

The coronavirus (COVID-19) pandemic has affected societies and economies around the world, and the scientific community is no exception. Whereas the importance of stakeholder engagement in research has grown quickly the consequences of the pandemic on this has so far not been empirically studied. In this paper, we investigate the effects of the COVID-19 crisis on European energy research, in particular the stakeholder work, during the first wave of the coronavirus in spring and summer 2020. We pose the research questions: (i) How much of a problem are the coronavirus containment measures for stakeholder engagement? (ii) How have researchers coped with the situation, and (iii) How do they evaluate alternative stakeholder activities implemented? We conducted an online survey among European energy research projects with stakeholder engagement between June and August 2020. We found that only one of six engagement activities could be implemented as planned, whereas almost half were cancelled or delayed. The most common coping strategies were changing involvement formats – mainly to webinars or online workshops – or postponement. Whereas respondents are largely satisfied with one-to-one and unidirectional online formats, such as webinars, online interviews, and online surveys, they see interactive group activities as less suitable for online engagement. Most respondents plan to continue using online formats to complement, but not to replace, physical meetings in future research. All long-term effects remain to be seen, but given the postponement of many stakeholder involvement activities, many projects may face problems at later stages of their realisation. These findings suggest that the pandemic may have catalysed a rapid introduction of specific online formats in academic stakeholder interaction processes.
Do we Need a Plant Theodicy?
Authors: Strickland Lloyd 
Published: September 2021

In recent decades, philosophers and theologians have become increasingly aware of the extent of animal pain and suffering, both past and present, and of the challenge this poses to God’s goodness and justice. As a result, a great deal of effort has been devoted to the discussion and development of animal theodicies, that is, theodicies that aim to offer morally sufficient reasons for animal pain and suffering that are in fact God’s reasons. In this paper, I ask whether there is a need to go even further than this, by considering whether effort should be made to extend theodicy to include plants as well. Drawing upon ideas found in some recent animal theodicies as well as in the work of some environmental ethicists, I offer three arguments for supposing that plants should indeed fall within the purview of theodicy: (1) the argument from non-flourishing as evil, (2) the argument from moral considerability, and (3) the argument from intrinsic value. I also consider a possible objection to each of these arguments. Having outlined and defended the aforementioned arguments for broadening theodicy to include plants as well as humans and animals, I conclude by considering what a plant theodicy might look like.
Theoretical verification of a silicon-wire flat-spectral-band wavelength filter based on multimode interference couplers with symmetric and asymmetric splitting ratios for the broadband operating range
Authors: Jeong Seok-Hwan 
Published: September 2021

A novel, to the best of our knowledge, device scheme for a silicon-nanowire flat-spectral-band wavelength optical filter is proposed and theoretically demonstrated. The proposed wavelength filter is composed of cascade-connected multiple delayed interference optical delay lines, together with several multimode interference couplers with symmetric and asymmetric splitting ratios. Theoretical calculations based on analytic and numerical simulations exhibit flatband spectra over a wavelength range of >80 nm with potentially better production yield for arbitrary channel spacing.
Temperature-dependent characteristics of infrared photodetectors based on surface-state absorption in silicon
Authors: Zhang Ziyu , Wang Zhao , Zou Kai , Yang Tianxin , Hu Xiaolong 
Published: September 2021

At various temperatures, ranging from 25°C to 50°C, we characterized two types of photodetectors based on surface-state absorption in silicon: (1) contactless integrated photonic probes (CLIPPs) and (2) normal-incidence photoconductors. Both types of photodetectors exhibited temperature-dependent AC admittance without illumination. With illumination at telecommunication wavelengths near 1550 nm, in the temperature range we measured, the photoresponse of CLIPPs, i.e., the variance of admittance due to illumination, was relatively insensitive to temperature changes; in comparison, the temperature dependence of the photoresponse of normal-incidence photoconductors was more pronounced—their responsivity increased as temperature raised.
3–6  µm dispersive mirrors compensating for dispersion introduced by the GaAs crystal
Authors: Chen Yu , Hahner Daniel , Pervak Vladimir 
Published: September 2021

A new broadband dispersive mirror (DM), which consists of Si and

S
i
O

2

layer materials operating in the spectral range of 3–6 µm, is developed for the first time, to our knowledge. The DM is able to compensate for the dispersion of a 0.5 mm thick GaAs crystal per bounce. Pulse analysis proves that the compensation effect of the DM is much better than a

C
a
F

2

plate, which is the commonly used dispersion compensation element in mid-infrared optical parametric oscillators (MIR OPOs), and the new MIR DM could improve the MIR OPO spectrum with better pulse quality and short pulse duration.
Digitalisierung von Management-Reporting-Prozessen – Ein technologieorientiertes Reifegradmodell zum Einsatz in KMU
Authors: Stoffers Pascal , Karla Jürgen , Kaufmann Jens 
Published: September 2021

ZusammenfassungDer Begriff der Digitalisierung umfasst eine große Bandbreite unterschiedlicher Themen und Aktivitäten. Zur gezielten Entwicklung von Unternehmen ist es daher erforderlich, die eigene Position und entsprechende Verbesserungspotenziale zu (er)kennen und eine erfolgreiche Prozess-Weiterentwicklung zu ermöglichen. Das Controlling eines Unternehmens nimmt als Informationslieferant und Bestandteil der Entscheidungsunterstützung in vielfältiger Hinsicht Einfluss auf bestehende und zu entwickelnde Geschäftsmodelle und ist von der Digitalisierung besonders betroffen, insbesondere hinsichtlich der Planungs- und Reporting-Prozesse.Zur Unterstützung der Digitalisierung vornehmlich in kleinen und mittleren Unternehmen wird ein Reifegradmodell entwickelt, das sich der beschriebenen Thematik widmet. Eine umfangreiche Vorstudie zeigt, welche existierenden Reifegradmodelle im Bereich der Managementinformation und des Controllings existieren und inwiefern diese noch nicht für die Fragestellung und/oder Anwendung ausreichend sind. Basierend auf der Identifikation von aktuellen, relevanten technologischen Entwicklungen werden Reifegradausprägungen eines neuen Modells erstellt, die die unterschiedlichen Dimensionen der unternehmerischen Tätigkeit einbeziehen.In diesem Beitrag wird das Modell zur Bestimmung des aktuellen Reifegrads von Unternehmen entwickelt und vorgestellt.
Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome
Authors: De Toma Ilario , Sierra Cesar , Dierssen Mara 
Published: September 2021

Trisomy of human chromosome 21 (HSA21) causes Down syndrome (DS). The trisomy does not simply result in the upregulation of HSA21--encoded genes but also leads to a genome-wide transcriptomic deregulation, which affect differently each tissue and cell type as a result of epigenetic mechanisms and protein-protein interactions.
We performed a meta-analysis integrating the differential expression (DE) analyses of all publicly available transcriptomic datasets, both in human and mouse, comparing trisomic and euploid transcriptomes from different sources. We integrated all these data in a “DS network”.
We found that genome wide deregulation as a consequence of trisomy 21 is not arbitrary, but involves deregulation of specific molecular cascades in which both HSA21 genes and HSA21 interactors are more consistently deregulated compared to other genes. In fact, gene deregulation happens in “clusters”, so that groups from 2 to 13 genes are found consistently deregulated. Most of these events of “co-deregulation” involve genes belonging to the same GO category, and genes associated with the same disease class. The most consistent changes are enriched in interferon related categories and neutrophil activation, reinforcing the concept that DS is an inflammatory disease. Our results also suggest that the impact of the trisomy might diverge in each tissue due to the different gene set deregulation, even though the triplicated genes are the same.
Our original method to integrate transcriptomic data confirmed not only the importance of known genes, such as SOD1, but also detected new ones that could be extremely useful for generating or confirming hypotheses and supporting new putative therapeutic candidates. We created “metaDEA” an R package that uses our method to integrate every kind of transcriptomic data and therefore could be used with other complex disorders, such as cancer. We also created a user-friendly web application to query Ensembl gene IDs and retrieve all the information of their differential expression across the datasets.
Relative risks of adverse events among older adults receiving opioids versus NSAIDs after hospital discharge: A nationwide cohort study
Authors: Herzig Shoshana J. , Anderson Timothy S. , Jung Yoojin , Ngo Long , Kim Dae H. , McCarthy Ellen P. 
Published: September 2021

Background
Although analgesics are initiated on hospital discharge in millions of adults each year, studies quantifying the risks of opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) among older adults during this transition are limited. We sought to determine the incidence and risk of post-discharge adverse events among older adults with an opioid claim in the week after hospital discharge, compared to those with NSAID claims only.

Methods and findings
We performed a retrospective cohort study using a national sample of Medicare beneficiaries age 65 and older, hospitalized in United States hospitals in 2016. We excluded beneficiaries admitted from or discharged to a facility. We derived a propensity score that included over 100 factors potentially related to the choice of analgesic, including demographics, diagnoses, surgeries, and medication coadministrations. Using 3:1 propensity matching, beneficiaries with an opioid claim in the week after hospital discharge (with or without NSAID claims) were matched to beneficiaries with an NSAID claim only. Primary outcomes included death, healthcare utilization (emergency department [ED] visits and rehospitalization), and a composite of known adverse effects of opioids or NSAIDs (fall/fracture, delirium, nausea/vomiting, complications of slowed colonic motility, acute renal failure, and gastritis/duodenitis) within 30 days of discharge. After propensity matching, there were 13,385 beneficiaries in the opioid cohort and 4,677 in the NSAID cohort (mean age: 74 years, 57% female). Beneficiaries receiving opioids had a higher incidence of death (1.8% versus 1.1%; relative risk [RR] 1.7 [1.3 to 2.3], p < 0.001, number needed to harm [NNH] 125), healthcare utilization (19.0% versus 17.4%; RR 1.1 [1.02 to 1.2], p = 0.02, NNH 59), and any potential adverse effect (25.2% versus 21.3%; RR 1.2 [1.1 to 1.3], p < 0.001, NNH 26), compared to those with an NSAID claim only. Specifically, they had higher relative risk of fall/fracture (4.5% versus 3.4%; RR 1.3 [1.1 to 1.6], p = 0.002), nausea/vomiting (9.2% versus 7.3%; RR 1.3 [1.1 to 1.4], p < 0.001), and slowed colonic motility (8.0% versus 6.2%; RR 1.3 [1.1 to 1.4], p < 0.001). Risks of delirium, acute renal failure, and gastritis/duodenitis did not differ between groups. The main limitation of our study is the observational nature of the data and possibility of residual confounding.

Conclusions
Older adults filling an opioid prescription in the week after hospital discharge were at higher risk for mortality and other post-discharge adverse outcomes compared to those filling an NSAID prescription only.
Implementation of mass drug administration for neglected tropical diseases in Guinea during the COVID-19 pandemic
Authors: Sakho Fatoumata , Badila Christelly Flore , Dembele Benoit , Diaby Aissatou , Camara Abdoul Karim , Lamah Lamine , Reid Steven D. , Weng Angel , Fuller Brian B. , Sanchez Katherine A. , Kabore Achille , Zhang Yaobi , Weaver Angela 
Published: September 2021

Background
Guinea reported its first case of COVID-19 on March 12, 2020. Soon thereafter, a national state of emergency was declared, all land borders were closed, schools were shut down, and public gatherings were limited. Many health activities, including field-based activities targeting neglected tropical diseases (NTDs), were paused. The World Health Organization (WHO) issued updated guidance on the resumption of NTD field-based activities on July 27, 2020. In response, the Guinea Ministry of Health (MoH) and its partners planned and resumed mass drug administration (MDA) in mid-August to September 2020 in 19 health districts.

Methodology/principal findings
A risk-benefit assessment was conducted to identify potential risks associated with the MDA in the COVID-19 context. Following this assessment, a risk mitigation plan with barrier measures was developed to guide MDA implementation. These measures included COVID-19 testing for all national staff leaving Conakry, mask wearing, social distancing of two meters, and hand washing/sanitizing. A checklist was developed and used to monitor compliance to risk mitigation measures. Data on adherence to risk mitigation measures were collected electronically during the MDA. A total of 120 checklists, representing 120 community drug distributor (CDD) teams (two CDDs per team) and 120 households, were completed. Results indicated that washing or disinfecting hands was practiced by 68.3% of CDD teams, compared to 45.0% among households. Face masks to cover the mouth and nose were worn by 79.2% of CDD teams, while this was low among households (23.3%). In 87.5% of households, participants did not touch the dose pole and in 88.3% of CDD teams, CDDs did not touch the hands of the participants while giving the drugs. A large majority of CDD teams (94.2%) and household members (94.2%) were willing to participate in the MDA despite the pandemic. The epidemiological coverage was ≥65% for lymphatic filariasis, onchocerciasis and soil-transmitted helminths in 10 out of 19 HDs and ≥75% for schistosomiasis for school-aged children in 7 out of 11 HDs.

Conclusions/significance
Guinea was one of the first countries in Africa to resume MDA activities during the COVID-19 pandemic without causing an observed increase of transmission. The development of a risk mitigation plan and a method to monitor adherence to barrier measures was critical to this unprecedented effort. The rapid incorporation of COVID-19 barrier measures and their acceptance by CDDs and household members demonstrated both the adaptability of the National NTD Program to respond to emerging issues and the commitment of the MoH to implement NTD programs.