bluuebunny/crossref_metadata_2025_split huggingface dataset:
A TEORIA DA PRÁTICA DE PIERRE BOURDIEU À LUZ DA NOÇÃO WEBERIANA DE TIPO IDEAL
Authors: Soares Rumbelsperger Rodrigues Daniel 
Published: April 2021

O artigo apresenta uma intepretação da teoria da prática e da epistemologia de Pierre Bourdieu a partir da pressuposição realista e da epistemologia neokantiana de Max Weber. Para isso, o trabalho expõe a noção de tipo ideal – sobretudo enquanto a forma conceitual por excelência das ciências sociais – no interior mais amplo da teoria do conhecimento weberiana. Num segundo momento, o artigo interpreta, com Vandenberghe (2011), a epistemologia bourdieusiana como uma espécie de síntese sofisticada do racionalismo de Bachelard com o relacionismo de Cassirer. Por fim, o artigo defende a tese de que tanto a epistemologia weberiana quanto o recurso de Bourdieu à “filosofia do como se” devem ser interpretados a partir da pressuposição realista de que as (re)descrições científicas podem corresponder (em medidas
variáveis) à realidade empírica. Com isso, o artigo procura ler a sociologia bourdieusiana menos como uma teoria da reprodução e mais como uma aposta na reflexividade e na mudança social.

Palavras - chave: Epistemologia. Teoria da Prática. Max Weber. Pierre Bourdieu
Characterizing the Relationship Between the Chemical Structures of Drugs and their Activities on Primary Cultures of Pediatric Solid Tumors
Authors: Simeon Saw , Ghislat Ghita , Ballester Pedro 
Published: April 2021

Background:
Despite continued efforts to develop new treatments, there is an
urgent need to discover new drug leads to treat tumors exhibiting primary or secondary
resistance to existing drugs. Cell cultures derived from patient-derived orthotopic xenografts
are promising pre-clinical models to better predict drug response in cancer recurrence.

Objective:
The aim of the study was to investigate the relationship between the physiochemical
properties of drugs and their in vitro potency as well as identifying chemical
scaffolds biasedtowards selectivity or promiscuity of such drugs.

Methods:
The bioactivities of 158 drugs screened against cell cultures derived from 30
cancer orthotopic patient-derived xenograft (O-PDX) models were considered. Drugs
were represented by physicochemical descriptors and chemical structure fingerprints. Supervised
learning was employed to model the relationship between features and in vitro
potency.

Results:
Drugs with in vitro potency for alveolar rhabdomyosarcoma and osteosarcoma
tend to have a higher number of rings, two carbon-hetero bonds and halogens. Selective
and promiscuous scaffolds for these phenotypic targets were identified. Highly-predictive
models of in vitro potency were obtained across these 30 targets, which can be applied
to unseen molecules via a webserver (https://rnewbie.shinyapps.io/Shobek-master).

Conclusion:
It is possible to identify privileged chemical scaffolds and predict the in vitro
potency of unseen molecules across these 30 targets This information and models
should be helpful to select which molecules to screen against these primary cultures of pediatric
solid tumors.
Cardiovascular Complications in Major 21st Century Viral Epidemics and
Pandemics: an Insight into COVID-19
Authors: Hussain Muzna , Collier Patrick , Moudgil Rohit 
Published: April 2021

:
There have many major history-defining epidemics and pandemics in the 21st century. It
is well known that acute infections can cause cardiovascular (CV) complications, especially in
those with underlying cardiac disease. The variation in rates and types of CVD complications in
major 21st century epidemics and pandemics varies greatly. The coronavirus disease 2019
(COVID-19) pandemic has caused the turmoil of the century and has COVID-19 has resulted in
substantial human and economic loss. The novelty of COVID-19 and emerging CV effects is a new
entity. In this review, we discuss the major epidemics and pandemics of the 21st century and associated
CVD complications.
Prospects of Delivering Natural Compounds by Polymer-Drug Conjugates in Cancer Therapeutics
Authors: Mthimkhulu Nompumelelo , Mosiane Karabo S. , Nweke Ekene E. , Balogun Mohammed , Fru Pascaline N. 
Published: April 2021

Abstract:
Synthetic chemotherapeutics have played a crucial role in minimizing mostly palliative symptoms
associated with cancer; however, they have also created other problems such as system toxicity due to a lack of
specificity. This has led to the development of polymer-drug conjugates amongst other novel drug delivery
systems. Most of the formulations designed using delivery systems consist of synthetic drugs and face issues
such as drug resistance, which has already rendered drugs such as antibiotics ineffective. This is further
exacerbated by toxicity due to the long-term use. Given these problems and the fact that conjugation of synthetic
compounds to polymers has been relatively slow with no formulation on the market after a decade of extensive
studies, the focus has shifted to using this platform with medicinal plant extracts to improve solubility, specificity
and increase drug release of medicinal and herbal bioactives. In recent years, various plant extracts such as
flavonoids, tannins and terpenoids have been studied extensively using this approach. The success of
formulations developed using novel drug-delivery systems is highly dependent on the tumour microenvironment
especially on the enhanced permeability and retention effect. As a result, the compromised lymphatic network
and ‘leaky’ vasculature exhibited by tumour cells act as a guiding principle in the delivery of these formulations.
This review focuses on the state of the polymer-drug conjugates and their exploration with natural compounds,
the progress and difficulties thus far, and future directions concerning cancer treatment.
A Critical Review of Obesity in Healthcare Systems in Brazil and Portugal: Pathways, Guidelines and Strategies
Authors: da Graça da Costa Luciane , de Oliveira Barbosa Adriana Aparecida , Weber Thabata Koester , Correia Flora , Monteiro Isabel , de Oliveira Maria Rita Marques 
Published: April 2021

Background:
Obesity and its associated diseases in the 21st century has led to new public policies with international commitments.

Objective:
The objective of this review was to examine public initiatives and policies to tackle obesity in Brazil and Portugal over the past two decades, identifying frameworks, guidelines and strategic actions.

Methods:
Official documents Brazilian and Portuguese public health policies were analyzed for international guidelines from 1999 to 2019. The documents were organized and analyzed by date. Additionally, they were evaluated for frameworks and actions proposed for individuals, communities, and the population across all levels of healthcare.

Conclusion:
This study shows that Portugal and Brazil have taken different paths when it comes to the creation and implementation of their strategies to manage obesity. In Brazil, actions aimed at promoting healthy eating have been introduced to children and are implemented by many government agencies. Portugal, on the other hand, has provided greater access to individualized healthcare services and has involved different sectors in addressing these issues.
Optimation of Combination of N-Hexane Solution and Ethyle Acetate on Secondary Metabolite Compounds Profile of Streptomyces hygroscopicus
Authors: Ariel Dio Giovanni , Winarsih Sri , Putri Fitria Febriliani , Erwan Nabila Erina , Putri Ajeng Maharani , Cahyono Alfian Wika , Mardhiyyah Kana , Fitri Loeki Enggar , Nugraha Rivo Yudhinata Brian 
Published: April 2021

Streptomyces hygroscopicus (S.hygroscopicus) is a Gram-positive soil bacterium that can produce secondary metabolites from fermentation that have a therapeutic effect. The fermented S. hygrocospicus metabolites that are still in the form of crude extracts are difficult to develop as drug preparations because the active compounds are not yet known, so it will be challenging to determine the dosage of drugs that have a therapeutic effect. Therefore, it is necessary to carry out exploratory research to narrow down the secondary metabolite profile from the fermentation of S. hygroscopicus, using extraction and fractionation methods, which are then identified by Thin-Layer Chromatography (TLC) using a combination of solvents. This study used the extraction method with a separating funnel. The fractionation was carried out using the BUCHI (SepacoreÂ®) Flash Chromatography and RevelerisÂ® PREP Purification System column chromatography gradually using ethyl acetate and n-hexana.Â 47 and 60 of the fractionation results were taken as samples, that further were profiled using TLC and given the appearance of 10% KOH stains and p-Anisaldehyde - sulfuric acid, so that various classes of compounds with different Rf values were obtained, namely Monoterpenes, Triterpenes, Steroids, Saponins, Coumarin, Scopoletin, and Alkaloids.
Learning the Mental Health Impact of COVID-19 in the United States With Explainable Artificial Intelligence: Observational Study
Authors: Jha Indra Prakash , Awasthi Raghav , Kumar Ajit , Kumar Vibhor , Sethi Tavpritesh 
Published: April 2021

Background
The COVID-19 pandemic has affected the health, economic, and social fabric of many nations worldwide. Identification of individual-level susceptibility factors may help people in identifying and managing their emotional, psychological, and social well-being.

Objective
This study is focused on learning a ranked list of factors that could indicate a predisposition to a mental disorder during the COVID-19 pandemic.

Methods
In this study, we have used a survey of 17,764 adults in the United States from different age groups, genders, and socioeconomic statuses. Through initial statistical analysis and Bayesian network inference, we have identified key factors affecting mental health during the COVID-19 pandemic. Integrating Bayesian networks with classical machine learning approaches led to effective modeling of the level of mental health prevalence.

Results
Overall, females were more stressed than males, and people in the age group 18-29 years were more vulnerable to anxiety than other age groups. Using the Bayesian network model, we found that people with a chronic mental illness were more prone to mental disorders during the COVID-19 pandemic. The new realities of working from home; homeschooling; and lack of communication with family, friends, and neighbors induces mental pressure. Financial assistance from social security helps in reducing mental stress during the COVID-19–generated economic crises. Finally, using supervised machine learning models, we predicted the most mentally vulnerable people with ~80% accuracy.

Conclusions
Multiple factors such as social isolation, digital communication, and working and schooling from home were identified as factors of mental illness during the COVID-19 pandemic. Regular in-person communication with friends and family, a healthy social life, and social security were key factors, and taking care of people with a history of mental disease appears to be even more important during this time.
Evaluasi Management Support pada Pengelolaan Obat di RSUD Kabupaten Ngawi
Authors: Yuniarti Fita Dewi , Satibi Satibi , Andayani Tri Murti 
Published: April 2021

Pengelolaan obat yang efektif dan efisien di instalasi farmasi rumah sakit meliputi tahap seleksi, pengadaan, distribusi dan penggunaan yang didukung oleh manajemen pendukung (management support) yang terdiri dari perencanaan administrasi, organisasi, sumber daya manusia, sistem informasi.Tujuan penelitian ini untuk mengetahui gambaran management support terhadap pengelolaan obat di Instalasi Farmasi RSUD Kabupaten Ngawi. Penelitian ini bersifat deskriptif menggunakan metode wawancara dan telaah dokumen. Data kuantitatif diambil secara retrospektif (tahun 2018); dan data kualitatif diperoleh dari wawancara dengan informan yang dipilih secara purposive sampling. Data hasil penelusuran dokumen dan wawancara diklasifikasikan menjadi 2 kelompok yaitu data kualitatif dan data kuantitatif. Data kualitatif berupa hasil wawancara disajikan dalam bentuk tekstual berupa narasi. Data kuantitatif dibandingkan dengan standar, kemudian disajikan dalam bentuk tabel.Dari hasil penelitian ini menunjukkan perencanaan dan administrasi pada persentase kesesuaian jumlah permintaan dan perencanaan 103,18%; persentase stok obat mati 0,4%; persentase obat ED 0,36%. dari manajemen organisasi, sudah terdapat struktur organisasi yang jelas sesuai dengan tugas, pokok dan fungsinya. Dari manajemen sumber daya manusia, memerlukan penambahan SDM apoteker. Dari manajemen sistem informasi: SIM yang ada hanya lokal untuk instalasi farmasi. Dari hasil penelitian ini menunjukkan bahwa pengelolaan obat di IFRS RSUD Kabupaten Ngawi belum efisien, karena belum didukung sepenuhnya oleh management support yang baik.
HUBUNGAN SAFETY CULTURE DENGAN PERILAKU KESEHATAN DAN KESELAMATAN KERJA PADA PUSAT TEKNOLOGI DAN KESELAMATAN REAKTOR NUKLIR BATAN TAHUN 2020
Authors: Mairing Carolyna , Wirawan I Made Ady , Deswandri Deswandri 
Published: April 2021

ABSTRAK
Safety culture merupakan budaya organisasi yang mengutamakan pada nilai–nilai dan sikap keselamatan. Walaupun instansi telah menghimbau tenaga kerja untuk mengutamakan keselamatan, namun tenaga kerja belum memahami bahwa perilaku K3 bagi tenaga kerja merupakan hal penting untuk menghindari PAK maupun KAK. Penelitian ini bertujuan untuk mengetahui hubungan safety culture dan faktor individu dengan perilaku K3 di Pusat Teknologi dan Keselamatan Reaktor Nuklir (PTKRN) BATAN. Penelitian ini menggunakan desain kuantitatif analitik dengan rancangan cross-sectional study. Responden pada penelitian ini berjumlah 51 orang dengan teknik pengambilan sampel purposive sampling. Hasil menunjukan proporsi responden berperilaku K3 baik sebesar 49,02%. Tingkat pendidikan yang lebih tinggi mempunyai proporsi perilaku K3 lebih tinggi secara bermakna (p=0,023), sedangkan pada variabel umur, jenis kelamin, masa kerja dan safety culture tidak berhubungan secara bermakna dengan perilaku K3 (p>0,05). Oleh karena itu perlu dicermati faktor penyebab lebih luas yang mempengaruhi perilaku K3. Selain itu pihak manajemen hendaknya melakukan upaya untuk meningkatkan perilaku K3.
Kata Kunci: Safety culture, Perilaku K3, Tenaga Kerja
Bentuk dan Makna Pertunjukan Tari Renteng di Desa Saren, Nusa Penida, Klungkung, Bali
Authors: Ruastiti Ni Made , Indrawan Anak Agung , Sariada Ketut 
Published: April 2021

This article discusses the meaning of Renteng Dance in the Saren Village of Nusa Penida. In Bali, there are many ceremonial dances, but recently many people have created ceremonial dances inspired by the Renteng Dance. This study focuses on the forms and meanings of the Renteng Dance shown in Saren Village. Data collected through observation, documentation study, and interviews with informants were analyzed descriptively using aesthetic theory and reception. It can be concluded that the people of Saren Village performed the Renteng Dance in the form of tari lepas which is a dance performance without stories. This can be seen from the presentation, choreography, and the music accompanying the performance. Renteng dance is accompanied by Balinese gamelan Balaganjur music with a specific movement dance performance structure. Saren community members support this dance because it has meaning as an expression of faith, social concern, and the interest in ecological preservation.
The Preference of The Sub-Urban Society in Choosing The Satellite Area of Denpasar City as a Residential
Authors: Wira Raditya Agung Angga , Sueca Ngakan Putu , Wirawibawa Ida Bagus Gde 
Published: April 2021

Villages suburb area around the border with the city of Denpasar is one of the area that’s also effected by the economic growth in Denpasar city. The area was settled by people due to sub-urban residential land in Denpasar increasingly difficult to reach and limited, especially those located in the center of Denpasar City. It makes people prefer living in the satellite city of Denpasar. The area included in the district of Gianyar, Badung, and Tabanan regency. This study aims to determine the preference that are considered sub-urban communities to choose satellite settlements in Denpasar. This study uses the positivist approach with merging between qualitative and quantitative case study. The research result obtained five factors are considered sub-urban communities to choose satellite settlements in Denpasar, among others: accessibility, availability of shopping facilities, environmental conditions, availability of electricity, and the pierce of land/house. Thus, accessibility becomes a major factors in the selection of the sub-urban residential location in the satellite city of Denpasar.
Index Terms— preference, settlement, sub-urban, sattellite settlement
Globalization Across the Disciplines: A Comparison of the Teaching of Globalization in Commerce and Global Development Studies at Queen’s University
Authors: Langill Jennifer 
Published: April 2021

It is often said that we are living in the "age of globalization." This research questions what is meant by this statement. The inquiry is divided into two areas of research. The first part is a review of the academic literature on globalization. Globalization was found to be a term used across a wide variety of disciplines. However, there is no consensus between the disciplines on what exactly the term encompasses. This led to the second area of research: Investigation of the teaching of globalization at Queen's University. For the scope of the research, undergraduate Commerce and Global Development Studies students were chosen. Students from either discipline filled out a survey on globalization and how it is taught at Queen'sUniversity. The results strongly indicated that the students in Commerce and Global Development Studies had very difference conceptions of globalization and were taught about it very differently. The larger implications for what the research findings suggest are discussed University and beyond, while also acknowledging the limitations of the scale of the research. The inquiry concludes with suggestions for moving forward, including further research and alterations to the teaching of globalization at Queen's.
12. Black Bear Conservation efforts in Ontario
Authors: Cummings Elizabeth , Neville Erin , Slater Allison , Zargarpour Nicci 
Published: April 2021

Over the past 200 years, large carnivore range has been decreased due to an increase in human density and influence through agriculture and industrialization. The black bear (Ursusa americanus) is a severely impacted species which has experienced nearly a 50% range loss and has been extirpated from parts of North America. Much public controversy surrounds this species, due to issues associated with hunting, human-bear interactions, and species management strategies. Increasing public awareness of black bear ecology, a charismatic megafauna, will spark positive and pro-conservation efforts across North America. Therefore, area and knowledge-specific education is important in engaging affected communities in black bear ecology and the importance of conservation. The Ministry of Natural Resources has made an effort in these areas by establishing the Bear Wise Program, however there is room within this program for expansion and development of their initiatives. Such expansions include improvement of public education, community outreach and youth awareness of black bears in a holistic ecosystem, versus case specific, approach. Identification of high-impact areas in Ontario would support the allocation of provincial resources to address these issues by implementing changes in local infrastructure, educational development and region-specific management. This project builds off of already established black bear management to increase region and province-wide conservation. The knowledge provided through this project will allow for future efforts across a wide geographical area.
13. Conservation Education in the Kingston Classroom
Authors: Primeau Courtney , Sauve Drew , Starkman Hava , Zengus Vincent 
Published: April 2021

In order to sustain and improve global and local conservation efforts, each incoming generation must become informed and active within the conservation field. If education surrounding conservation can be improved and preserved, the importance of maintaining an intact natural world will be better understood and passed on. We hope to address this issue through examination of the current state of subject material surrounding conservation biology in the Limestone District School Board (LDSB) in Kingston, Ontario. Material in eachgrade will be analyzed and a report on the current state of environmental and conservation education will be prepared. We also hope to gather expert opinions on the questions relating to: what grade level conservation education will make the largest impact on and the current pressing issues in conservation biology. These expert opinions will be gathered from both researchers and educators here at Queens as well as teachers and administration in the school board. We hope to compile all information gathered, to then prepare five lessons for a conservation biology science unit. We hope to work in a classroom to teach one of these prepared unit lessons and get feedback on the lesson from both teachers and students.From all the information gathered we hope to provide a plan for improvement on the overall conservation curriculum in addition to designing a specific unit of conservation biology for elementary school students. The report will also examine the process of implementing curriculum into a school system, providing a tool for other conservation biologists who are inclined to improve the education system.
Metamorphic evolution for the Inyoni shear zone: Investigating the geodynamic evolution of a 3.20 Ga terrane boundary in the Barberton granitoid greenstone terrane, South Africa
Authors: Cutts K.A. , Maneiro K.A. , Stevens G. , Baxter E.F. 
Published: April 2021

Abstract
The Inyoni shear zone represents an important tectonic boundary between (i) the ca. 3.45 Ga high-pressure amphibolite facies, granite-greenstone domain south of the Barberton greenstone belt, termed the Stolzburg terrane, and (ii) the ca. 3.29 to 3.23 Ga rocks of the trondhjemitic Badplaas pluton to the west. The Stolzburg terrane is separated from the greenschist facies rocks of the rest of the Barberton greenstone belt by the Komati fault, which records &gt;10 km uplift of the Stolzburg terrane relative to the lower-grade rocks of the greenstone belt at ca. 3.23 Ga. A number of studies within the Stolzburg terrane have documented high-pressure amphibolite facies metamorphism that occurred concurrently with exhumation, with the lowest apparent geothermal gradients documented in the Inyoni shear zone, where strong constraints on the age of metamorphism are most limited. In addition, different studies on Inyoni metamorphism have produced significantly different temperature estimates.
This study utilizes garnet Sm-Nd geochronology in combination with P-T modelling to directly date the metamorphism and re-evaluate the P-T conditions of the Inyoni shear zone. Two petrologically distinct samples produce similar P-T evolutions. A heterogeneous sample with both garnet-bearing and garnet-absent domains gives up-P evolutions reaching conditions of 550 to 675°C and 7 to 10 kbar, whereas a homogenous sample containing garnet and clinopyroxene produces a similar dominantly up-P evolution reaching peak conditions of 650°C and 8 to 10 kbar. Sm-Nd garnet ages of 3 201.6 ± 4.7 Ma (MSWD = 1.02) and 3 200.3 ± 5.3 Ma (MSWD = 0.44) were obtained from two samples of the homogenous garnet and clinopyroxene-bearing amphibolite. The Sm-Nd garnet geochronology provides accurate ages for the metamorphism of the Inyoni shear zone, with age results suggesting activity on the Inyoni shear zone may have continued after the regional metamorphism at ca. 3.23 Ga previously established by zircon U-Pb geochronology. However, 147Sm decay constant uncertainty leaves open the possibility that Inyoni garnet growth could have coincided with the previously recognized 3.23 Ga regional metamorphism.