bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the role of service quality, trust and commitment to customer loyalty for telecom service users: a PLS-SEM approach
Authors: Kalia Prateek , Kaushal Robin , Singla Meenu , Parkash Jai 
Published: October 2021

PurposeThe purpose of this paper is to determine the role of service quality (SQ), trust and commitment to customer loyalty (CL) for telecom service users. Further, the moderating role of gender, marital status and connection type within the model was tested.Design/methodology/approachA measurement model was created based on valid 615 responses from Indian TSUs for SQ, trust, commitment and loyalty with the help of partial least squares structural equation modeling (PLS-SEM). Multi-group analysis (MGA) was conducted to understand the moderating effect of marital status, gender and connection type within the model.FindingsThe results suggest that, out of five dimensions of SQ, only responsiveness, assurance and empathy have a significant positive relationship with both commitment and trust. Tangibility has a significant positive relationship with trust only. Both commitment and trust have a significant impact on loyalty. It was noticed that both commitment and trust act as mediators between three SQ dimensions (assurance, empathy and responsiveness) and CL. MGA revealed that empathy and responsiveness positively induce trust in telecom users who are single. Whereas, assurance increases commitment toward telecom service providers in married users. Assurance and empathy significantly contribute toward commitment and trust, respectively, in male users as compared to females. Empathy was found important for postpaid users for trust-building, whereas trust was found to be more important for prepaid users to stay loyal to the service provider.Originality/valueThis article contributes toward understanding the role of SQ, trust and commitment to CL moderated by marital status, gender and connection type in an integrated model concerning telecom service.
Populations restored using regional seed are genetically diverse and similar to natural populations in the region
Authors: Höfner Johannes , Klein‐Raufhake Theresa , Lampei Christian , Mudrak Ondrej , Bucharova Anna , Durka Walter 
Published: October 2021

Abstract

Ecological restoration and plant re‐introductions aim to create plant populations that are genetically similar to natural populations to preserve the regional gene pool, yet genetically diverse to allow adaptation to a changing environment. For this purpose, seeds for restoration are increasingly sourced from multiple populations in the target region. However, it has only rarely been tested whether using regional seed indeed leads to genetically diverse restored populations which are genetically similar to natural populations.

We used single nucleotide polymorphism (SNP) markers to investigate genetic diversity within and differentiation among populations of Centaurea jacea and Betonica officinalis on restored and natural meadows in the White Carpathians, Czech Republic. The restoration took place 20 years ago using regional seeds propagated from a mix of multiple regional source populations. We included original regional seeds in our analysis to compare the restored populations with their origin (only in C. jacea). Additionally, we analysed conventional seeds without certified origin because these would have constituted a common alternative for restoration seeding in the absence of regional seeds.

The differentiation between restored and natural populations (mean pairwise FST = 0.018 in Centaurea and 0.021 in Betonica) was similar to the differentiation among natural populations (FST = 0.023 and 0.021), and the restored populations were slightly more genetically diverse than the natural populations. In addition, restored populations were relatively similar to their origin, the regional seeds (FST = 0.015). In contrast, conventional seeds were strongly differentiated from all regional populations (FST = 0.100 and 0.059, in Centaurea and Betonica respectively) and harboured substantially lower genetic diversity. We also found signs of gene flow via pollen or seed dispersal from natural to restored populations but not vice versa.

Policy implications. Regionally sourced seeds can produce genetically diverse populations at natural levels of genetic differentiation.
Between Microeconomics and Geopolitics: On the Reasonable Application of Competition Law
Authors: Andriychuk Oles 
Published: October 2021

AbstractFor decades competition law was interpreted and applied through the prism of the economic analysis of law. This approach has advantages, enabling one to master both the methodological and normative features of the field. The use of economic rationality helps one to understand the motivation of market agents. The use of advanced mathematics allows robust modelling of the wide variety of empirical and theoretical factors. The use of efficiency and consumer welfare helps one to calibrate the goals of competition law. Such a ‘standard’ perception of the discipline, however, is in a deep crisis, and – as this article explains – chiefly for the right reasons. The conceptual divide between the representatives of Law and Economics and those adhering to a more societal account of competition law has many levels and dimensions. This article investigates the foundational aspect of the divide: the divergence in epistemic perception of legal and economic expertise.
Cronkhite–Canada syndrome: An investigation in clinical features and pathogenesis
Authors: Zhu Lan Ping , Zhong Wei Long , Wang Ze Gui , Sun Kai Di , Liu Qin Ling Fei , Zhao Jing , Zhao Jing Wen , Chen Xin , Wang Bang Mao 
Published: October 2021

ObjectiveThis study aimed to investigate the clinical features and potential pathogenesis of a rare nonhereditary polyposis syndrome, Cronkhite–Canada syndrome (CCS).MethodsMedical records of eight patients with CCS who were admitted to our hospital from January 2005 to November 2019 were reviewed. Transcriptome profiling was performed in one patient to investigate its difference between gastric polyp tissue and normal mucosa. Differentially expressed genes (DEGs) were determined for functional analysis. The expression of inhibin beta A (INHBA) was further assessed by using immunohistochemistry.ResultsAll patients presented with gastrointestinal polyposis, accompanied by diarrhea, skin hyperpigmentation, hair loss and nail dystrophy. Hyperplastic polyps were observed in seven patients, tubular adenoma in two, inflammatory polyps in one and hamartomatous polyps in one, respectively. All patients underwent comprehensive treatment and five achieved clinical remission. A total of 2107 DEGs, including 1265 upregulated and 842 downregulated, were found in the gastric polyp. Gene ontology analysis showed that upregulated genes were significantly enriched in the positive regulation of cell proliferation, epithelium development and angiogenesis. A protein–protein interaction analysis suggested that INHBA was at the center of the interaction network and might play an important role in CCS. Immunohistochemistry confirmed that INHBA expression was upregulated in CCS gastric polyps.ConclusionsCCS is a rare disease and its diagnosis mainly depends on typical clinical manifestations, endoscopic findings and histological features. INHBA upregulation may contribute to its pathogenesis.
Endorsement of specific alcohol use disorder criterion items changes with age in individuals with persistent alcohol use disorders in 2 generations of the San Diego Prospective Study
Authors: Schuckit Marc A. , Smith Tom L. 
Published: October 2021

AbstractBackgroundDiagnostic and Statistical Manual (DSM) alcohol use disorder (AUD) criteria are written in broad enough terms to apply to diverse populations. The current analyses evaluate whether the endorsement of criteria changes with increasing age in individuals with persistent AUDs.MethodsData regarding AUDs persisting across 3 timepoints between average ages of 31 and 43 were gathered about every 5 years from 318 interviews for 106 San Diego Prospective Study (SDPS) AUD male probands. Similar data regarding persistent AUDs across 2 timepoints were obtained from 136 interviews with 68 SDPS AUD offspring between average ages of 21 and 27. Changes in the endorsement of each AUD criterion were evaluated using Cochran's Q test.ResultsFor AUD probands across time, significant decreases were observed in the proportions endorsing 4 criteria (tolerance, withdrawal, failure to fulfill obligations, and using alcohol in hazardous situations). Increased rates of endorsement were documented for 3 criteria (drinking alcohol in higher amounts or for longer periods of time, spending a great deal of time regarding alcohol, and continued use despite social or interpersonal problems). Significant increases in rates of endorsements for offspring were seen for spending a great deal of time regarding alcohol and giving up or reducing important activities in order to drink.ConclusionsThese data indicate that the salience of many DSM AUD criterion items changed significantly with age in both SDPS generations among individuals with persistent AUDs. The current results support the need for additional systematic research to determine whether specific criterion items might need to be weighted differently in evaluating older and younger individuals with persistent AUDs.
The association between visual display terminal use and dry eye: a review
Authors: Fjærvoll Haakon , Fjærvoll Ketil , Magno Morten , Moschowits Emily , Vehof Jelle , Dartt Darlene A. , Utheim Tor P. 
Published: October 2021

AbstractBackgroundDry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. It causes ocular symptoms, reduced quality of life and a considerable economic burden on society. Prolonged use of visual display terminals (VDTs) has been suggested as an important risk factor for DED.PurposeThis review aims to study the association between DED and VDT use with an emphasis on the prevalence of DED among VDT users and harmful daily duration of VDT use.MethodsA PubMed search was conducted and yielded 57 relevant articles based on a set of inclusion and exclusion criteria. The studies were subclassified according to study design.ResultsThe far majority of the studies showed an association between VDT use and DED or DED‐related signs and symptoms. The prevalence of definite or probable DED in VDT and office workers ranged from 26% to 70%, with as few as 1–2 hr of VDT exposure per day being associated with DED.ConclusionVDT use is strongly associated with DED. VDT‐associated DED is prevalent, but the exact prevalence needs to be further elucidated using standardized DED diagnosis criteria. Furthermore, a safe lower limit of daily VDT use has yet to be established. More research is needed on the effect of digitalization and digital transformation, which are particularly high during the time of the COVID‐19 pandemic.
Impact of Depreciation Information on Capital Budgeting among Local Governments: A Survey Experiment
Authors: Kuroki Makoto 
Published: October 2021

AbstractThis study investigates the impact of depreciation practices on the internal decision making of local government (LG) budget officers. Prior studies focus on depreciation practices that influence decision making and policy formulation through financial performance indicators. However, such practices are also expected to affect capital asset management. Specifically, the presence of depreciation information makes it possible for budget officers to account for the burden of current and future generations such as depreciation costs and debt interests when budgeting. Thus, this study tests the impact of depreciation information on capital budgeting by conducting a survey experiment with all 1788 LGs in Japan. A questionnaire was sent to LG budget officers with two patterns of experimental groups: decision making for capital budgeting (a) without depreciation information and (b) with depreciation information. The experimental results show that budget officers’ capital budget decisions are influenced by the presence of depreciation information. This study contributes to accounting and public sector research and practice by showing the impact of depreciation information on the decision making of LG budget officers for capital budgeting.
A SPIDR homozygous nonsense pathogenic variant in isolated primary ovarian insufficiency with chromosomal instability
Authors: Heddar Abdelkader , Guichoux Nathalie , Auger Nathalie , Misrahi Micheline 
Published: October 2021

AbstractPrimary ovarian insufficiency (POI), affecting 1% of women under 40 years is a public health problem. Genes involved in meiosis/DNA repair were recently shown to be the leading family of associated causal genes, some of them also cause tumors/cancers. Here, using targeted next‐generation sequencing in an Indian POI patient with primary amenorrhea and streak ovaries, we identified a novel homozygous nonsense variant in exon 7 of SPIDR (KIAA0146) c.814C > T, R272*, predicted to lead a nonsense‐mediated mRNA decay. SPIDR was recently identified by in vitro assays as an auxiliary protein interacting with RAD51 and BLM, two major proteins involved in genome stability. Consistent with alteration of the RAD51 pathway, we observed a strong increase in mitomycin C‐induced DNA breaks and aberrant metaphases in the patient's cells compared to a control. However, sister chromatid exchanges were normal in contrast to the sharp increase characteristic of the BLM pathway. This is the first evidence of chromosomal instability associated with a SPIDR molecular defect, which supports the role of SPIDR in double‐stranded DNA damage repair in vivo in humans and its causal role in POI. Our study increases knowledge on the SPIDR function and has broad implications in the management of such patients.
GDF15 expression in glioma is associated with malignant progression, immune microenvironment, and serves as a prognostic factor
Authors: Guo Longbin , Chen Yulei , Hu Shushu , Gao Lianxuan , Tang Nan , Liu Rongping , Qin Yue , Ren Chen , Du Shasha 
Published: October 2021

AbstractAimsGrowth differentiation factor 15 (GDF15) is involved in lots of crucial inflammatory and immune response. The clinical and immune features for GDF15 in glioma have not been specifically investigated so far.MethodsGene expression profiles obtained from public glioma datasets were used to explore the biological function of GDF15 and its impact on immune microenvironment. Interference with GDF15 in several glioma cell lines to verify its functions in vitro. Survival data were used for the survival analysis and establishment of a nomogram predictive model.ResultsGDF15 was up‐regulated in various malignant phenotypes of glioma. Function analysis and in vitro experiments revealed that GDF15 was associated with malignant progression and NF‐κB pathway. GDF15 was closely correlated to inflammatory response, infiltrating immune cells, and immune checkpoint molecules, especially in lower grade glioma (LGG). High expression level of GDF15 predicted poor survival in LGG, while the effect on glioblastoma (GBM) was not significant. A nomogram predictive model combining GDF15 and other prognostic factors was constructed and showed ideal predictive performance.ConclusionsGDF15 could serve as an interesting prognostic biomarker for LGG. Regulating the expression of GDF15 may help solve the dilemma of immunotherapy in glioma.
Adverse events during sedation for oro‐dental trauma in an Israeli paediatric emergency department
Authors: Bilder Leon , Librov Simona , Gutmacher Zvi , Pasternak Idit , Shavit Itai 
Published: October 2021

AbstractThere is a paucity of data regarding the safety of the practice of sedation for oro‐dental trauma in paediatric emergency departments (ED). A previous study reported the safety of intramuscular ketamine administered as a single agent. In the paediatric ED of a tertiary trauma centre in Israel, one of two ketamine‐based regimens is used for sedating children with intraoral injuries according to the physician's discretion: a single dose of intramuscular ketamine or a combination of ketamine and propofol (KP) intravenously. The aim of this study was to assess the safety of KP sedation in children undergoing emergency treatment of oro‐dental injuries in this paediatric ED. The primary outcome was sedation adverse events that required intervention (SAERI): prolonged oxygen desaturation and apnoea, laryngospasm, hypotension, bradycardia, partial or complete airway obstruction, and pulmonary aspiration. During the 2 years study period, 17 children were sedated with KP, 20 with intramuscular ketamine and 29 with nitrous oxide. Patients who were treated with ketamine‐based sedation or with nitrous oxide sedation had a median (interquartile range, IQR) age of 3 (2–4) years and 7 (5–9) years, respectively. No SAERI occurred in patients who were sedated with intramuscular ketamine. One (3.4%) SAERI was reported in a patient who was sedated with N2O. Six/17 (35%) SAERI occurred in patients who were sedated with KP. These findings suggest that caution should be used when young children with oro‐dental injuries are sedated with KP in the ED.
Why does it matter to individuate the senses: A Brentanian approach
Authors: Fréchette Guillaume 
Published: October 2021

AbstractHow do we individuate the senses, what exactly do we do when we do so, and why does it matter? In the following article, I propose a general answer to these related questions based on Franz Brentano's views on the senses. After a short survey of various answers offered in the recent literature on the senses, I distinguish between two major ways of answering this question, causally and descriptively, arguing that only answers giving priority to description and to the classification involved in it are on the right track for a general answer to the related questions. In the second part of the article, I argue that Brentano's descriptive psychology is an attractive candidate for such an answer. His descriptive psychology provides a plausible account of the classification involved in description, in particular regarding the classification of sensory qualities. I close the article by briefly explaining how Brentano spells out the priority of descriptive answers over causal ones.
“The universal word speaks only in dialect”
Authors: Jahnel Claudia 
Published: October 2021

AbstractPostcolonial theories announce an “exit”: the departure from the West as the world’s centre of gravity and from Eurocentric hegemonic claims of superiority, turning away from the universal, and placing unheard voices at the centre – those who are excluded from academic, public, and political discourse. Such stories and histories of the margins do not simply represent “other” stories from the “periphery.” Rather, the stories of the margins are constitutive for the history of Europe and the invention of European modernity. Today’s manifestations of global Christianity are no exception to these dynamics. There are various models of alternative universalisms and conceptions of unity, where the crucial questions are: who defines the unity of the churches and has the monopoly over interpretation and – related to this, but a little more radically – whether such a formulation of unity must necessarily repeat Western grammar or whether there are not entirely other grammars and epistemologies of unity. Postcolonial theories and postcolonial practices in particular offer promising perspectives in dealing with these questions.
Ecumenical Engagement for Human Rights
Authors: Prove Peter 
Published: October 2021

AbstractThis article was originally given as a keynote address on 15 June 2021 to the annual Karlsruhe Foyer Church and Law reception, which gathered church representatives, judges of the German Federal Constitutional Court and Federal Court of Justice, as well as representatives of the Federal Prosecutor's Office. After recounting the contributions made by the World Council of Churches (WCC) to the development of the international human rights framework and the evolution of its own approach to these issues, it highlights increasing challenges in recent years to this legal framework for the protection of human dignity. It concludes by looking toward the WCC’s 11th Assembly in Karlsruhe, Germany, in 2022 as an opportunity for churches to rise above these challenges and to become even more engaged in support of human rights and the legal framework developed for their promotion and protection.
Democracy at the EU level: Folly or necessity? More work for a directly elected European Parliament
Authors: Lord Christopher 
Published: October 2021

AbstractIt is often argued that the European Union needs legitimation by its Member State democracies. However, there is also a reverse dependence in which Member State democracies need some kind of European Union if they are to manage externalities between themselves in ways that are needed to deliver their most fundamental obligations to their own publics to secure rights, justice, freedom from arbitrary domination and democracy itself. I argue that reverse dependence provides an additional justification for a directly elected European Parliament: namely, as an aid to national democracies in their oversight of Union decisions. The future of Europe debates should consider a directly elected Parliament as a means of connecting national democracies to the Union and not just of building representative institutions at the European level.
The isolated Erebia pandrose Apennine population is genetically unique and endangered by climate change
Authors: Sistri Ginevra , Menchetti Mattia , Santini Luca , Pasquali Lorenzo , Sapienti Sofia , Cini Alessandro , Platania Leonardo , Balletto Emilio , Barbero Francesca , Bonelli Simona , Casacci Luca Pietro , Dincă Vlad , Vila Roger , Mantoni Cristina , Fattorini Simone , Dapporto Leonardo 
Published: October 2021

Abstract
Climate change is causing shifts in the distribution of many species and populations inhabiting mountain tops are particularly vulnerable to these threats because they are constrained in altitudinal shifts. Apennines are a relatively narrow and low mountain chain located in Southern Europe, which hosts many isolated populations of mountain species. The butterfly Erebia pandrose was recorded for the last time in the Apennines in 1977, on the top of a single massif (Monti della Laga).
We confirmed the presence of a small, isolated population of E. pandrose in the Apennines, at a distance of more than 400 km to any other known populations. Then, we examined the cytochrome c oxidase subunit 1 mitochondrial DNA marker of this species across the Palaearctic area and estimated the potential decline over the Alps and the Apennines due to future climatic changes.
The Apennine population represents an endemic lineage characterised by eight mutations over the 658 bp analysed (1.2%). In the Alps and Apennines, this species has shifted uphill more than 3 m per year since the end of the 19th century and more than 22 m per year since 1995. Species distribution models suggested that these mountain populations will experience a generalised loss of climatic suitability, which, according to our projections, could lead to the extinction of the Apennine population in a few decades.
Erebia pandrose has the potential to become a flagship species for advertising the risk of losing unique fractions of genetic diversity for mountain species.