bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological respiratory parameters in pre-hospital patients with suspected COVID-19: A prospective cohort study
Authors: Mälberg Johan , Hadziosmanovic Nermin , Smekal David 
Published: September 2021

Background
The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients with COVID-19 and predicting the severity of their illness. The aim of this study was to investigate whether physiological respiratory parameters in pre-hospital patients with COVID-19 differed from those without COVID-19 and if they could be used to aid EMS personnel in the prediction of illness severity.

Methods
Patients with suspected COVID-19 were included by EMS personnel in Uppsala, Sweden. A portable respiratory monitor based on pneumotachography was used to sample the included patient’s physiological respiratory parameters. A questionnaire with information about present symptoms and background data was completed. COVID-19 diagnoses and hospital admissions were gathered from the electronic medical record system. The physiological respiratory parameters of patients with and without COVID-19 were then analyzed using descriptive statistical analysis and logistic regression.

Results
Between May 2020 and January 2021, 95 patients were included, and their physiological respiratory parameters analyzed. Of these patients, 53 had COVID-19. Using adjusted logistic regression, the odds of having COVID-19 increased with respiratory rate (95% CI 1.000–1.118), tidal volume (95% CI 0.996–0.999) and negative inspiratory pressure (95% CI 1.017–1.152). Patients admitted to hospital had higher respiratory rates (p<0.001) and lower tidal volume (p = 0.010) compared to the patients who were not admitted. Using adjusted logistic regression, the odds of hospital admission increased with respiratory rate (95% CI 1.081–1.324), rapid shallow breathing index (95% CI 1.006–1.040) and dead space percentage of tidal volume (95% CI 1.027–1.159).

Conclusion
Patients taking smaller, faster breaths with less pressure had higher odds of having COVID-19 in this study. Smaller, faster breaths and higher dead space percentage also increased the odds of hospital admission. Physiological respiratory parameters could be a useful tool in detecting COVID-19 and predicting hospital admissions, although more research is needed.
La vie chromatique des objets. Une anthropologie de la couleur de l’art contemporain - Arnaud Dubois, 2019
Authors: Barré Sandra 
Published: September 2021

Recensé : Arnaud Dubois, La vie chromatique des objets. Une anthropologie de la couleur de l’art contemporain, Turnhout, Brepols, 2019 (« Techne »), 260 p.
Incidencia de las organizaciones de la sociedad civil latinoamericana (OSCL) en la creación de ambientes habilitantes para su deliberación.
Authors: Artamonov Alexander , Marín Aranguren Erli Margarita 
Published: September 2021

En el financiamiento al desarrollo, las Organizaciones de Sociedad Civil fueron reconocidas como actores por derecho propio; y los involucrados se comprometieron a crear ambientes habilitantes. El artículo discute los efectos de participación de Sociedad Civil en Agenda de Eficacia de Ayuda sobre sus capacidades de incidencia dirigida a la creación de ambientes propicios para su deliberación. Como hallazgo, se puede constatar el aumento en la capacidad de incidencia de organizaciones de la Sociedad Civil dirigida a la creación de ambientes propicios como resultado de su participación en Agenda de Eficacia de Ayuda.
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry
Authors: Großkopf Henning , Vogel Sarah , Müller Claudia Damaris , Köhling Sebastian , Dürig Jan-Niklas , Möller Stephanie , Schnabelrauch Matthias , Rademann Jörg , Hempel Ute , von Bergen Martin , Schubert Kristin 
Published: September 2021

Abstract
Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). Artificial GAGs like sulfated hyaluronan (sHA) exhibit pro-osteogenic properties and boost healing processes. Hence, they are of high interest for supporting bone regeneration and wound healing. Although sulfated GAGs (sGAGs) appear intracellularly, the knowledge about intracellular effects and putative interaction partners is scarce. Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). Overall, 477 proteins were found interacting with at least one of four distinct sGAGs. Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. Respecting the preferentially intracellular localization of sGAG in vesicle-like structures, also the interaction data indicate sGAG-specific modulation of vesicle-based transport processes. By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects.
Variables are valuable: making a case for deductive modeling
Authors: Tizón-Couto David , Lorenz David 
Published: September 2021

AbstractFollowing the quantitative turn in linguistics, the field appears to be in a methodological “wild west” state where much is possible and new frontiers are being explored, but there is relatively little guidance in terms of firm rules or conventions. In this article, we focus on the issue of variable selection in regression modeling. It is common to aim for a “minimal adequate model” and eliminate “non-significant” variables by statistical procedures. We advocate an alternative, “deductive modeling” approach that retains a “full” model of variables generated from our research questions and objectives. Comparing the statistical model to a camera, i.e., a tool to produce an image of reality, we contrast the deductive and predictive (minimal) modeling approaches on a dataset from a corpus study. While a minimal adequate model is more parsimonious, its selection procedure is blind to the research aim and may conceal relevant information. Deductive models, by contrast, are grounded in theory, have higher transparency (all relevant variables are reported) and potentially a greater accuracy of the reported effects. They are useful for answering research questions more directly, as they rely explicitly on prior knowledge and hypotheses, and allow for estimation and comparison across datasets.
Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/mTOR signaling pathway
Authors: Ou Yi , Zhang Wenjuan , Chen Shaopeng , Deng Haihua 
Published: September 2021

Abstract

Objective
To investigate the effect of baicalin on diabetic nephropathy (DN) rats and podocytes and its mechanism.

Methods
The rat models with DN were established by high-fat and high-sugar diet and intraperitoneal injection of streptozotocin. The fasting blood glucose (FBG) and weight of rats in each group were measured at 0, 1, 2, 3, and 4 weeks. Their biochemical indicators, expression of inflammatory, and antioxidant factors were measured using an automatic biochemical analyzer together with ELISA. Hematoxylin–eosin staining and periodic acid-schiff staining were used to observe the morphological changes in the kidneys of rats in each group. Finally, the expressions of related molecules and PI3K/Akt/mTOR signaling pathway proteins in renal tissues and podocytes were examined by qRT-PCR and Western blot.

Results
Compared with the DN group, the FBG and weight, serum creatinine, blood urea nitrogen, total cholesterol, triacylglycerol, microalbumin, and albumin/creatinine ratio were all significantly decreased in the Baicalin treatment groups in a concentration-dependent manner. The levels of inflammatory factors in kidney tissue and podocytes were decreased. In addition, the activities of lactate dehydrogenase and malondialdehyde in tissue were decreased, while the superoxide dismutase was increased. The pathological sections showed that glomerular atrophy and glomerular basement membrane thickening caused by hyperglycemia were improved in the Baicalin treatment groups. Meanwhile, baicalin inhibited the downregulation of Nephrin and Podocin expressions and upregulation of Desmin expression caused by DN, and inhibited the expressions of p-PI3K, p-Akt, and p-mTOR proteins.

Conclusion
Baicalin slows down podocyte injury caused by DN by inhibiting the activity of PI3K/Akt/mTOR signaling pathway.
Hurdle in taxonomy: A case of malaria parasites and other Haemosporidia
Authors: Mandal Fatik Baran 
Published: September 2021

AbstractA crucial progress in taxonomy matches with the growth of various branches of biological sciences. This validates the taxonomic positions of many organisms.Haemoproteus, Leucocytozoon and Plasmodium,the members of the Haemosporidia, are the well recognized parasitic genera. Revisiting the progress in animal taxonomy appears to be important to evaluate our studies. Haemosporidia being microscopic, their taxonomy specially the morphotaxonomy has sometimes created confusion. Therefore, analysis of progression of the taxonomy of the avian Haemosporidia demands special attention. Modern phylogenetic analyses revealed a wealth of information, which is undoubtedly useful for protozoology and other related sciences. Techniques of molecular taxonomy are applied to draw the phylogeny covering members of Haemosporidia. The study of the life cycles of both hosts and parasites are absorbing. Besides, analysis of their evolution through molecular phylogenetics appears to be vital in studying haemosporidians and to gain insight for basic and applied sciences. This article examines the potential of molecular phylogenetics in refining systematics of avian Haemosporidia and to explain a holistic view of the group.
The influence of gas purification and addition of macro amounts of metal-carbonyl complexes on the formation of single-atom metal-carbonyl-complexes
Authors: Wittwer Yves , Eichler Robert , Zingg Ronald , Herrmann Dominik , Türler Andreas 
Published: September 2021

AbstractUsing the Fast On-line Reaction Apparatus (FORA), the influence of various gas-purification columns onto the formation of metal carbonyl complexes (MCCs) under single-atom chemistry conditions was investigated. MCCs were synthesized from single atoms of Mo, Tc, Ru and Rh being produced by the spontaneous fission of252Cf and recoiling into a CO-gas containing carrier gas atmosphere. Thein-situsynthesized MCCs were volatile enough to be transported by the carrier gas to a charcoal trap where they were adsorbed and their subsequent decay was registered byγ-spectrometry. It was found that the type and combination of purification columns used to clean the applied CO-gas strongly influences the obtained formation and transport yields for all MCCs. With the exception of Rh-carbonyl, intense gas-purification strategies resulted in reduced formation and transport yields for MCCs in comparison with less efficient or even completely missing purification setups. It was postulated that the observed reduction in yield might depend on the content of Fe(CO)5and Ni(CO)4, as well as potentially other MCCs, in the CO-gas, being formed by the interaction between CO and the steel-surfaces of FORA as well as from impurities in the used charcoal traps. Subsequently, it was shown that macro amounts of Fe(CO)5, Ni(CO)4, Mo(CO)6and Re2(CO)10added to the used process gas indeed increase significantly the overall yields for MCCs produced by252Cf fission products. Ni(CO)4appeared the most potent to increase the yield. Therefore, it was used in more detailed investigations. Using isothermal chromatography, it was shown that Ni(CO)4 does not affect the speciation of carbonyl species produced by the 252Cf fission product 104Mo. For 107Tc, 110Ru and 111Rh a speciation change cannot be excluded. For111Rh a speciation change cannot be excluded. An inter-carbonyl transfer mechanism is suggested boosting the formation of MCCs. The current discovery might allow for new opportunities in various research fields, which are currently restricted by the low overall yields for MCCs produced under single-atom chemistry conditions. Examples are the chemical investigation of transactinides or the generation of radioactive ion beams from refractory metals at accelerators.
A szórvány magyar tanköteles gyermekek családon kívüli elhelyezése Baranyában az 1941–1942-es tanévben
Authors: Niklai Patrícia Dominika 
Published: September 2021

The framework for the placing of Hungarian compulsory school children outside the family was based on the 25.360/1941. Religion and Public Education Ministerial decree, which constituted new provisions from the 1941/1942 school year for the education of native Hungarian children living in non-Hungarian environment. The reason for issuing the decree was the growing demand of the nationalities for education in their native language, which the Hungarian state – after the failure of the unified education system introduced in 1935 – made available to them in 1941. This measure was supported by nationalities as well, but at the same time we must not forget that the Horthy-era represented a strong national policy, and the patriotic, national education began in elementary school. Thus, the education of Hungarian children could not be neglected while striving to fulfil the needs of nationalities. According to paragraph 1 of the 25.360/1941. Religion and Public Education Ministerial decree on the education of Hungarian children: ‘A native Hungarian compulsory school child living in Hungary, who stays in a not native Hungarian environment must be educated in a Hungarian school or class, by a traveling teacher, in a Hungarian boarding school, or in another native Hungarian environment.’ The placing of children outside the family was only necessary if there was no school with Hungarian educational language in the municipality, because in that case ‘a native Hungarian child living in the municipality (city) can only be sent by his or her tutelary to such a school, until reaching the age of compulsory schooling.’ In accordance with the decree, from the summer of 1941 the Education Inspectorate collected data on the native Hungarian compulsory school children who lived in a non-Hungarian environment to provide them enrolment elsewhere. The first version of the options listed in the decree (Hungarian school or class in municipality) is not the subject of the study, since in that case, the child remains in the family. The second version – a traveling teacher – would not cause change either, but I did not find any example of this in the archives anyway. What may be more interesting in the terms of Family law is the placing in a boarding school or with a family of a relative or acquaintance in native Hungarian environment - this is indicated by the phrase in an otherwise ‘native Hungarian environment’. I give examples of these cases – boarding school and placement in Hungarian families – from practice based on archival records.
Seizure Phenotype and Underlying Cellular Defects inDrosophilaKnock-In Models of DS (R1648C) and GEFS+ (R1648H)SCN1AEpilepsy
Authors: Roemmich Alexa Joanna , Vu Thy , Lukacsovich Tamas , Hawkins Charlesice , Schutte Soleil S. , O’Dowd Diane K. 
Published: September 2021

AbstractMutations in the voltage-gated sodium channel geneSCN1Aare associated with human epilepsy disorders, but how most of these mutations alter channel properties and result in seizures is unknown. This study focuses on two different mutations occurring at one position withinSCN1A. R1648C (R-C) is associated with the severe disorder Dravet syndrome, and R1648H (R-H), with the milder disorder GEFS+. To explore how these different mutations contribute to distinct seizure disorders,Drosophilalines with the R-C or R-H mutation, or R1648R (R-R) control substitution in the fly sodium channel geneparawere generated by CRISPR-Cas9 gene editing. The R-C and R-H mutations are homozygous lethal. Animals heterozygous for R-C or R-H mutations displayed reduced life spans and spontaneous and temperature-induced seizures not observed in R-R controls. Electrophysiological recordings from adult GABAergic neurons in R-C and R-H mutants revealed the appearance of sustained neuronal depolarizations and altered firing frequency that were exacerbated at elevated temperature. The only significant change observed in underlying sodium currents in both R-C and R-H mutants was a hyperpolarized deactivation threshold at room and elevated temperature compared with R-R controls. Since this change is constitutive, it is likely to interact with heat-induced changes in other cellular properties to result in the heat-induced increase in sustained depolarizations and seizure activity. Further, the similarity of the behavioral and cellular phenotypes in the R-C and R-H fly lines, suggests that disease symptoms of different severity associated with these mutations in humans could be due in large part to differences in genetic background.
Інженерні методи розрахунку процесу гідратації при обробці олії електромагнітними хвилями
Authors: Осадчук Петро Ігорович , Безбах Ігор Віталійович 
Published: September 2021

До основних недоліків стандартних ліній гідратації відносяться висока енергоємність, велика витрата холодної води і пари, що зв'язано з використанням сепараторів, а також жорстким температурними режимами сушіння фосфоліпідної емульсії. Ці лінії не забезпечують ефективність процесу в цілому через високий залишковий зміст фосфоліпідів в олії і низької харчової цінності одержуваних фосфатидних концентратів унаслідок впливу перекису водню, застосовуваної для знебарвлення. Для усунення цих недоліків було запропоновано використання електромагнітних полів в процесі гідратації олій.
В даній роботі запропоновано інженерні методи розрахунку процесу гідратації при обробці олії електромагнітними хвилями. Проведено моделювання процесу.
Використовуючи метод аналізу розмірностей, отримано критеріальне рівняння для розрахунку продуктивності устаткування. Проведено узагальнення експериментальних даних отриманих в результаті досліджень.
Розроблено алгоритм розрахунку степеневих показників та констант в рівнянні у числах подібності, який реалізовано у середовищі Microsoft Excel. Визначено ступінь впливу напруженості магнітного поля на процес гідратації. Враховано залежить коефіцієнту масопередачі від зміни температури. З отриманого рівняння в числах подібності розраховано ряд теоретичних значень числа Стантона та порівняно з експериментальними даними.
Визначено розбіжність між розрахунковими та експериментальними даними в межах 18%. Отримане рівняння дає змогу розраховувати об’єм установки та швидкість протікання процесу, задаючись різними режимними параметрами: напруженістю магнітного поля, температурою.
Застосування абсорбційної ІЧ - спектроскопії для виявлення складу димо-повітряної суміші горіння деревини при копченні м’ясних виробів
Authors: Ощипок Ігор Миколайович 
Published: September 2021

В статті досліджені перспективи виявлення вмісту димо-повітряних компонентів в повітрі, що утворюються при спалюванні деревини. Розглянуті задачі з детектування слідів газоподібних речовин в локальній зоні повітряного середовища. Дане завдання відноситься до числа найбільш складних завдань газового аналізу, що обумовлюється малими концентраціями шуканих речовин і навпаки, високим вмістом сполук, що перешкоджають аналізу. Звернута увага на інтерпретації ІЧ спектрів, які полягають у тому, що враховується не тільки положення максимумів характеристичних смуг, але і на їх інтенсивності, формі, розташуванню щодо інших смуг. Про природу і кількість речовини в димо-повітряної суміші можна судити відповідно по числу і положенню піків в ІЧ-спектрах поглинання (якісний аналіз), а за інтенсивністю цих смуг - про кількість речовини (кількісний аналіз). Поліпшення чутливості і селективності методу можливе шляхом підвищення роздільної здатності приладів, а також використання різних прийомів формування та обробки аналізованого сигналу. Одним із прийомів формування аналізованого сигналу є диференційний метод. використовуваний метод повинен бути високочутливим, точним, швидкодіючим і забезпечувати селективність виявлення складових димо-повітряної суміші, і може припускати роботу на деякій відстані. Розглянута ідея методу, яка полягає в одночасному пропусканні через димо-повітряну суміш, що знаходиться в термокамері зондуючого випромінювання на двох довжинах хвиль, перша з яких збігається з максимумом смуги поглинання досліджуваної речовини, а друга так звана опорна до неї довжина хвилі, тобто довжина хвилі близька до зондуючої, але яка не лежить в смузі поглинання. Співвідношення сигналів на виході опорного і вимірювального каналів не залежить від стабільності джерела і приймача випромінювання.
PEDAGOGO COMO ORIENTADOR DE ENSINO E APRENDIZAGEM NA EDUCAÇÃO DISTÂNCIA
Authors: BRAZ FERREIRA GONTIJO SIMONE , Rodrigues de Queiroz Costa Eliziane 
Published: September 2021

Este artigo é parte de uma pesquisa de mestrado que discute as atividades desenvolvidas pelo pedagogo em cursos da modalidade Educação a Distância (EaD) no interior de uma equipe multidisciplinar de coordenação pedagógica, a qual desempenha a função de Orientador de Ensino e Aprendizagem (OEA). A função do OEA é acompanhar, orientar e apoiar as atividades docentes. Considerando a centralidade do trabalho pedagógico e a natureza singular e inovadora dessa função na EaD, a pesquisa analisou a percepção do trabalho do OEA no âmbito da coordenação pedagógica dos cursos ofertados por um Instituto Federal a partir da percepção dos profissionais. Foi adotada a pesquisa qualitativa, por meioda realização de um estudo de caso, e os dados foram coletados a partir da entrevista semiestruturada e do grupo focal. Recorreu-se à ferramenta tecnológica Alceste para subsidiar a análise do conteúdo dos dados. Os resultados apontam que existe uma percepção positiva a respeito do trabalho do OEA na equipe multidisciplinar. Porém há insatisfações desse profissional quanto ao papel do pedagogo na EaD, o que implica a limitação do trabalho pedagógico a uma atividade técnica. A insatisfação do OEA se dá, principalmente, pela falta de clareza do papel dele por parte da equipe diretiva da EaD, pela limitação das atividades deste ao nível técnico-operacional, pela percepção de que a gestão almeja um profissional com formação em pedagogia e design instrucional.