bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and predictors of psychological distress following injury: findings from a prospective cohort study
Authors: Richardson Amy E. , Derrett Sarah , Samaranayaka Ariyapala , Wyeth Emma H. 
Published: June 2021

Abstract
Background
Research examining psychological distress in people who have experienced an injury has focused on those with serious injuries or specific injury types, and has not involved long-term follow up. The aims of this investigation were to describe the prevalence of, and factors contributing to, psychological distress in a cohort of people with a broad range of injuries.

Methods
The Prospective Outcomes of Injury Study (POIS) is a longitudinal cohort study of 2856 injured New Zealanders recruited from a national insurance entitlement claims register between 2007 and 2009. Participants were interviewed approximately 3, 12, and 24 months after their injury. The Kessler Psychological Distress Scale (K6) was used to measure psychological distress at each interview.

Results
25% of participants reported clinically relevant distress (K6 ≥ 8) 3 months post-injury, 15% reported distress at 12 months, and 16% reported distress at 24 months. Being 45 years or older, Māori or Pacific ethnicity, experiencing pre-injury mental health conditions, having inadequate pre-injury income, reporting poor pre-injury health or trouble accessing healthcare, having a severe injury or an injury resulting from assault, and reporting clinically relevant distress 3 months post-injury were independently associated with an increased risk of distress 12 months post-injury. The majority of these associations were also evident with respect to distress 24 months post-injury.

Conclusions
Distress is common after injury among people with a broad range of injury types and severities. Screening for distress early after injury is important to identify individuals in need of targeted support.
Mineralogical and physico-chemical properties of halloysite-bearing slip surface material from a landslide during the 2018 Eastern Iburi earthquake, Hokkaido
Authors: Kameda Jun 
Published: June 2021

AbstractDestructive landslides were triggered by the 6.7 MwEastern Iburi earthquake that struck southern Hokkaido, Japan, on 6 September 2018. Heavy rainfall on 4 September in addition to intermittent rainfall around the Iburi Tobu area saturated and weakened the slope-forming materials (mostly altered volcanoclastic soils), making them susceptible to failure because of the earthquake’s strong ground motion. Most of the shallow landslides exhibited long runouts along gentle hill slopes, with characteristic halloysite-bearing slip surface at the base of the volcanic soils. This study investigated the mineralogical and physico-chemical properties of the slip surface material with the aim of understanding weakening and post-failure behaviors during the landslides. Halloysite in the slip surface had irregular-to-hollow-spherical morphology with higher mesopore volumes than tubular halloysite, which is related to a high capacity for water retention after rainfall. To reproduce possible chemical changes in the slip surface during rainfall, the sample was immersed in varying amounts of rainwater; solution pH increased and ionic strength decreased with increasing water content. These findings, alongside electrophoretic analysis, suggest that rainwater infiltration could have increased the absolute zeta potential value of the slip surface material. It is suggested that rainfall before the earthquake enhanced the colloidal stability of halloysite particles within the slip surface, owing to an increase in electrostatic repulsion. This decreased the material’s cohesive strength, which might have led to destabilization of the slope during ground shaking generated by the earthquake, and subsequent high-mobility flow after failure.
The digestive tract as an essential organ for water acquisition in marine teleosts: lessons from euryhaline eels
Authors: Takei Yoshio 
Published: June 2021

AbstractAdaptation to a hypertonic marine environment is one of the major topics in animal physiology research. Marine teleosts lose water osmotically from the gills and compensate for this loss by drinking surrounding seawater and absorbing water from the intestine. This situation is in contrast to that in mammals, which experience a net osmotic loss of water after drinking seawater. Water absorption in fishes is made possible by (1) removal of monovalent ions (desalinization) by the esophagus, (2) removal of divalent ions as carbonate (Mg/CaCO3) precipitates promoted by HCO3− secretion, and (3) facilitation of NaCl and water absorption from diluted seawater by the intestine using a suite of unique transporters. As a result, 70–85% of ingested seawater is absorbed during its passage through the digestive tract. Thus, the digestive tract is an essential organ for marine teleost survival in the hypertonic seawater environment. The eel is a species that has been frequently used for osmoregulation research in laboratories worldwide. The eel possesses many advantages as an experimental animal for osmoregulation studies, one of which is its outstanding euryhalinity, which enables researchers to examine changes in the structure and function of the digestive tract after direct transfer from freshwater to seawater. In recent years, the molecular mechanisms of ion and water transport across epithelial cells (the transcellular route) and through tight junctions (the paracellular route) have been elucidated for the esophagus and intestine. Thanks to the rapid progress in analytical methods for genome databases on teleosts, including the eel, the molecular identities of transporters, channels, pumps and junctional proteins have been clarified at the isoform level. As 10 y have passed since the previous reviews on this subject, it seems relevant and timely to summarize recent progress in research on the molecular mechanisms of water and ion transport in the digestive tract in eels and to compare the mechanisms with those of other teleosts and mammals from comparative and evolutionary viewpoints. We also propose future directions for this research field to achieve integrative understanding of the role of the digestive tract in adaptation to seawater with regard to pathways/mechanisms including the paracellular route, divalent ion absorption, metabolon formation and cellular trafficking of transporters. Notably, some of these have already attracted practical attention in laboratories.
Bridging the state and market logics of refugee labour market inclusion – a comparative study on the inclusion activities of German professional chambers
Authors: Maletzky de García Martina 
Published: June 2021

AbstractDue to their high numbers, refugees’ labour market inclusion has become an important topic for Germany in recent years. Because of a lack of research on meso-level actors’ influences on labour market inclusion and the transcendent role of organizations in modern societies, the article focuses on the German professional chambers’ role in the process of refugee inclusion. The study shows that professional chambers are intermediaries between economic actors, the government and refugees, which all follow their own logics and ideas of labour market inclusion (the state, the market and the community logic). The measures taken by professional chambers mainly reflect a governmental logic (to reduce refugee unemployment) combined with a market logic (to provide human resources to economic actors). A community logic (altruism) only comes into play as a rather unintended consequence of measures addressing the other two logics. The measures of two types of professional chambers are compared. Close similarities between them reveal that the organization type is of theoretical relevance to explain the type of measures organizations opt for.
Sero-molecular epidemiology of hepatitis E virus in pigs and human contacts in Ghana
Authors: Yeboah Richmond , Sylverken Augustina Angelina , Owusu Michael , El-Duah Philip , Burimuah Vitus , Frimpong Yaw , Lamptey Jones , Eckerle Isabella , Meyer Benjamin , Antwi Christopher , Agbenyaga Olivia , Folitse Raphael , Emikpe Benjamin , Oppong Samuel Kingsley , Adu-Sarkodie Yaw , Drosten Christian 
Published: June 2021

AbstractBackgroundHepatitis E virus (HEV) is among the leading causes of viral hepatitis in most developing countries. Zoonotic acquisition of HEV genotype 3 from swine has come into focus more recently. Available studies on HEV in Ghana and other countries in the region do not provide enough information towards understanding the epidemiology of HEV in human and animal populations. Towards this end, we conducted a comparative cross-sectional study to determine the seroprevalence and risk factors associated with HEV exposure, both in swine and humans working on pig farms in typical local settings. The presence of viral RNA in human and swine samples was also evaluated, along with classification of viral sequences from HEV-positive samples.MethodsStructured questionnaires soliciting information on pigs reared, as well as socio-demographic information including age, sex and educational background of humans was collected. A total of 10 ml and 5 ml of whole blood was collected from pigs and human participants respectively. ELISA and real-time RT-PCR were performed on the sera for the qualitative detection of IgG antibodies to hepatitis E virus and viral RNA, respectively.ResultsFive hundred and forty-four (544) human participants including 264 swine contacts and 280 swine non-contacts were enrolled in the study. Although the proportion of HEV IgG antibodies was higher in contact groups (114; 54.3%) than non-contact groups (96; 45.7%), a multivariate analysis did not show any significant difference. No HEV RNA was detected in human samples. Similarly, 720 pigs were sampled from 18 farms located in five regions in Ghana. Twenty-three (23) of the pigs (3.2, 95%CI = 2.0–4.8) were positive for HEV RNA by real-time RT-PCR testing. Sequences obtained from HEV-positive samples were found to share high sequence identities with each other and clustered with other genotype 3 viruses indicating the existence of circulating zoonotic genotype 3 viruses on farms. Although we did not find evidence of pig to human transmission of HEV genotype 3, the presence of this genotype in pigs shows the potential for possible zoonotic transmission in African farm settings and buttresses the importance of active surveillance for the infection among at risk populations.
A simplified method for calculating spectral emission of nonequilibrium air plasmas in hypersonic shock-layers
Authors: He Xin , Gao Cheng , Jiang Tao 
Published: June 2021

AbstractA simplified method for calculating the spectral emission of nonequilibrium air plasmas is developed. In order to obtain the nonequilibrium energy level populations, the nonequilibrium coefficients are introduced into the Saha-Boltzmann equation. These nonequilibrium coefficients are calculated by using several significant radiative processes. An approach to the determination of nonequilibrium electronic energy level populations of diatomic molecules is also presented. Based on the method, spectral emission of atoms and molecules in a typical air plasma cell is investigated. The results reveal that there is a significant difference between the nonequilibrium and equilibrium emission. We apply the method to the nonequilibrium AVCO R-156 experiment. Good agreement with the NEQAIR code and the measured data is shown, indicating that the method is reasonable and has good accuracy.
Sustaining implementation facilitation: a model for facilitator resilience
Authors: Olmos-Ochoa Tanya T. , Ganz David A. , Barnard Jenny M. , Penney Lauren , Finley Erin P. , Hamilton Alison B. , Chawla Neetu 
Published: June 2021

Abstract
Background
Implementation facilitators enable healthcare staff to effectively implement change, yet little is known about their affective (e.g., emotional, mental, physical) experiences of facilitation. We propose an expansion to the Integrated Promoting Action on Research in Health Services (i-PARIHS) framework that introduces facilitation intensity and facilitator resilience to better assess facilitators’ affective experiences.

Methods
We used an instrumental case study and facilitator data (logged reflections and debrief session notes) from the Coordination Toolkit and Coaching initiative to conceptualize facilitation intensity and facilitator resilience and to better understand the psychological impact of the facilitation process on facilitator effectiveness and implementation success.

Results
We define facilitation intensity as both the quantitative and/or qualitative measure of the volume of tasks and activities needed to engage and motivate recipients in implementation, and the psychological impact on the facilitator of conducting facilitation tasks and activities. We define facilitator resilience as the ability to cope with and adapt to the complexities of facilitation in order to effectively engage and motivate staff, while nurturing and sustaining hope, self-efficacy, and adaptive coping behaviors in oneself.

Conclusions
Facilitators’ affective experience may help to identify potential relationships between the facilitation factors we propose (facilitation intensity and facilitator resilience). Future studies should test ways of reliably measuring facilitation intensity and facilitator resilience and specify their relationships in greater detail. By supporting facilitator resilience, healthcare delivery systems may help sustain the skilled facilitator workforce necessary for continued practice improvement.

Trial registration
The project was registered with ClinicalTrials.gov (NCT03063294) on February 24, 2017.
An algorithm to simulate nonstationary and non-Gaussian stochastic processes
Authors: Hong H. P. , Cui X. Z. , Qiao D. 
Published: June 2021

AbstractWe proposed a new iterative power and amplitude correction (IPAC) algorithm to simulate nonstationary and non-Gaussian processes. The proposed algorithm is rooted in the concept of defining the stochastic processes in the transform domain, which is elaborated and extend. The algorithm extends the iterative amplitude adjusted Fourier transform algorithm for generating surrogate and the spectral correction algorithm for simulating stationary non-Gaussian process. The IPAC algorithm can be used with different popular transforms, such as the Fourier transform, S-transform, and continuous wavelet transforms. The targets for the simulation are the marginal probability distribution function of the process and the power spectral density function of the process that is defined based on the variables in the transform domain for the adopted transform. The algorithm is versatile and efficient. Its application is illustrated using several numerical examples.
Effects of the ABCB1 c.3435C>T (rs1045642) Polymorphism on Heat Pain Perception in Opioid-Free Adults With Chronic Pain
Authors: Hooten W. Michael , Hu Danqing , Cunningham Julie M. 
Published: June 2021

BACKGROUND:
The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain (HP) perception in a group of opioid-free adults with chronic pain.

METHODS:
Opioid-free adults with chronic pain consecutively admitted to a pain rehabilitation program comprised the study cohort (N = 134). Individuals were genotyped for the c.3435C>T (rs10454642) polymorphism. The polymorphism was analyzed with nonparametric tests using a dominant (cytosine-cytosine [CC] versus cytosine-thymine [CT] + thymine-thymine [TT]) and recessive (CC + CT versus TT) model of allele effects. Quantitative sensory testing was performed using the Computer Aided Sensory Evaluator IV system.

RESULTS:
The distribution of genotypes was 22% (N = 29) for CC, 45% (N = 60) for CT, and 33% (N = 45) for TT (Hardy-Weinberg, P > .1). A significant association was observed between the recessive model and HP threshold. Standardized values of HP threshold were significantly greater in the TT group than the CC + CT group (median difference, −0.77; 95% confidence interval [CI], −1.49 to −0.23; P = .005), and the effect size estimate was small (Cliff delta = 0.30). In the dominant model, no significant difference in HP threshold was observed between the CC and CT + TT groups (median difference, −0.45; 95% CI, −1.15 to 0.00; P = .108).

CONCLUSIONS:
These results posit that the efflux of endogenous opioid peptides is reduced in individuals with the TT genotype due to lower expression of P-gp, which, in turn, results in higher HP threshold. This study contributes to the emerging understanding of how the ABCB1 c.3435C>T polymorphism contributes to pain perception in opioid-free adults with chronic pain and provides the foundation for investigating the potential effects of this polymorphism on the clinical course of chronic pain.
Textual Authority in the Vita Nova’s Nineteenth-Century Editions
Authors: Todorović Jelena 
Published: June 2021

Abstract
This article focuses on the nineteenth-century print circulation of Dante’s Vita Nova (1292–94) and especially on the response in print media to the tension between new critical approaches to text editing, on the one hand, and editors’ dependence on the text’s complex history on the other. At the center of this discussion is one of the thorniest aspects of the Vita Nova’s text: the divisions (technical prose of a scholastic nature in which Dante explains the formal structure of his poems). Over the centuries, Dante’s authority over his own text was brought into question on account of the inclusion in the literary text of what readers and editors considered to be commentary. Even though in the second half of the nineteenth century the editors began recognizing the divisions’ rightful place within the libello’s text, they continued—operating within the centuries-long tradition that did not consider them “text” but rather “gloss”—to engage in efforts to differentiate them from the rest of the text in order to point out their different textual nature.
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway
Authors: Li Chengyu , Liu Zhaojun , Wu Gang , Zang Ziyu , Zhang Jia-Qing , Li Xiaoxuan , Tao Jingli , Shen Ming , Liu Honglin 
Published: June 2021

ABSTRACT
The development of ovarian follicles constitutes the foundation of female reproduction. The proliferation of granulosa cells (GCs) is a basic process required to ensure normal follicular development. However, the mechanisms involved in controlling GC cell cycle are not fully understood. Here, by performing gene expression profiling in the domestic pig (Sus scrofa), we showed that cell cycle arrest at G0/G1 phase is highly correlated with pathways associated with hypoxic stress and FOXO signalling. Specifically, the elevated proportion of GCs at the arrested G0/G1 phase was accompanied by increased nuclear translocation of FOXO1 under conditions of hypoxia both in vivo and in vitro. Furthermore, phosphorylation of 14-3-3 by the JNK kinase is required for hypoxia-mediated FOXO1 activation and the resultant G0/G1 arrest. Notably, a FOXO1 mutant without DNA-binding activity failed to induce G0/G1 arrest of GCs during hypoxia. Importantly, we identified a new target gene of FOXO1, namely TP53INP1, which contributes to suppression of the G1-S cell cycle transition in response to hypoxia. Furthermore, we demonstrated that the inhibitory effect of the FOXO1-TP53INP1 axis on the GC cell cycle is mediated through a p53-CDKN1A-dependent mechanism. These findings could provide avenues for the clinical treatment of human infertility caused by impaired follicular development.
Structural variability and dynamics in the ectodomain of an ancestral-type classical cadherin revealed by AFM imaging
Authors: Nishiguchi Shigetaka , Oda Hiroki 
Published: June 2021

ABSTRACT
Type III cadherin represents the ancestral form of classical cadherin in bilaterian metazoans. Drosophila possesses type III and type IVa cadherins, known as DN- and DE-cadherins, respectively. Mature DN- and DE-cadherins have 15 and 7 extracellular cadherin domain (EC) repeats, respectively, with DN-cadherin EC6–EC11 homologous to DE-cadherin EC1–EC6. These EC repeats contain predicted complete or partial Ca2+-free inter-EC linkers that potentially contribute to adhesion. Comparative structure–function studies of DN- and DE-cadherins may help us understand the ancestral and derived states of classical cadherin-mediated adhesion mechanisms. Here, using bead aggregation assays, we found that DN-cadherin EC1–EC11 and DE-cadherin EC1–EC6 exhibit Ca2+-dependent adhesive properties. Using high-speed atomic force microscopy (HS-AFM) imaging in solution, we show that both DN- and DE-cadherin ectodomains share a common morphological framework consisting of a strand-like and a globule-like portion. Furthermore, the DN-cadherin EC repeats are highly variable, flexible in morphology and have at least three bendable sites, one of which is located in EC6–EC11 and can act as a flexible hinge. Our findings provide insights into diversification of classical cadherin-mediated adhesion mechanisms.
This article has an associated First Person interview with the first author of the paper.
Generation of propulsive force via vertical undulations in snakes
Authors: Jurestovsky Derek J. , Usher Logan R. , Astley Henry C. 
Published: June 2021

ABSTRACT
Lateral undulation is the most widespread mode of terrestrial vertebrate limbless locomotion, in which posteriorly propagating horizontal waves press against environmental asperities (e.g. grass, rocks) and generate propulsive reaction forces. We hypothesized that snakes can generate propulsion using a similar mechanism of posteriorly propagating vertical waves pressing against suitably oriented environmental asperities. Using an array of horizontally oriented cylinders, one of which was equipped with force sensors, and a motion capture system, we found snakes generated substantial propulsive force and propulsive impulse with minimal contribution from lateral undulation. Additional tests showed that snakes could propel themselves via vertical undulations from a single suitable contact point, and this mechanism was replicated in a robotic model. Vertical undulations can provide snakes with a valuable locomotor tool for taking advantage of vertical asperities in a variety of habitats, potentially in combination with lateral undulation, to fully exploit the 3D structure of the habitat.