bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM INFORMASI GEOGRAFIS (GIS) PADA RUMAH SAKIT DI KABUPATEN LABUHANBATU BERBASIS WEB
Authors: Ritonga Heri Syahputra , Irmayani Deci , Pane Ramadhani 
Published: April 2021

Abstract: Geographical information system (GIS) is a tool with computer and android systems used to map conditions and events that occur on earth. With the current mapping system's capabilities, it can be used by the community. There are still few people who know the hospitals around them, especially with people outside the district. They have to ask the local community to find out the location of the hospital. With a system designed to provide convenience through determining the hospital location points that are available on the system. The data collection process and methods using the waterfall method. Testing this geographic information system with BlackBox. Someone searches Al-Aziz hospital data by selecting the al-Aziz hospital symbol contained in the system. A detailed menu will appear on the symbol so that it provides information about the hospital address, the schedule for opening and closing of the clinic, the name of the doctor, receiving PBJS health patient services, and the doctor's practice schedule at Al-Aziz Hospital. Keywords: Blackbox Testing; Hospital; Location; Waterfall method; Webgis Abstrak: Sistem Informasi Geografis (SIG) adalah alat komputer dan sistem android yang digunakan untuk memetakan kondisi dan peristiwa yang terjadi di bumi. Dengan kemampuan sistem pemetaan yang ada saat ini dapat dimanfaatkan oleh masyarakat. Masih sedikit masyarakat yang mengetahui rumah sakit di sekitar mereka, terutama yang berada di luar kabupaten. Mereka harus meminta masyarakat sekitar untuk mengetahui lokasi rumah sakit tersebut. Dengan sistem yang dirancang untuk memberikan kemudahan melalui penentuan titik lokasi rumah sakit yang tersedia dalam sistem. Proses dan metode pengumpulan data menggunakan metode waterfall. Uji sistem informasi geografis ini dengan BlackBox. Seseorang mencari data rumah sakit Al-Aziz dengan memilih simbol rumah sakit al-Aziz yang terdapat dalam sistem. Pada simbol ini akan muncul menu detil sehingga memberikan informasi mengenai alamat rumah sakit, jadwal buka tutup klinik, nama dokter, penerimaan pelayanan pasien kesehatan PBJS, dan jadwal praktek dokter di RS Al-Aziz. Kata kunci: Blackbox Testing; Lokasi; Rumah sakit; Waterfall; Webgis
Two New Antiprotozoal Diterpenes From the Roots of Acacia nilotica
Authors: Anyam John V. , Daikwo Priscilla E. , Ungogo Marzuq A. , Nweze Nwakaego E. , Igoli Ngozichukwuka P. , Gray Alexander I. , De Koning Harry P. , Igoli John O. 
Published: April 2021

The powdered roots of the medicinal plant Acacia nilotica were extracted with hexane and ethyl acetate, and the extracts were subjected to column chromatography for the isolation of potentially bioactive compounds and their screening against kinetoplastid pathogens. NMR and HREI mass spectrometric analyses identified two new diterpenes, characterized as 16, 19-dihydroxycassa-12-en-15-one (Sandynone, 1) and (5S, 7R, 8R, 9R, 10S, 13Z, 17S)-7,8:7,17:16,17-triepoxy-7,8-seco-cassa-13-ene (niloticane B, 2). The previously reported (5S,7R,8R,9R,10S) -(-)-7,8-seco-7, 8-oxacassa-13,15-diene-7,17-diol (3), (5S,7R,8R,9R,10S) -(-)-7,8-seco-7, 8-oxacassa-13,15-dien-7-ol-17-al (4), and (5S,7R,8R,9R,10S) -(-)-7,8-seco-7, 8-oxacassa-13,15-dien-7-ol (5) a, mixture of stigmasterol (6a) and sitosterol (6b), and lupeol (7) were also isolated. Several column fractions displayed significant activity against a panel of Trypanosoma and Leishmania spp., and from the most active fraction, compound 4 was isolated with high purity. The compound displayed high activity, particularly against T. brucei, T. evansi, and L. mexicana (0.88–11.7 µM) but only a modest effect against human embryonic kidney cells and no cross-resistance with the commonly used melaminophenyl arsenical and diamidine classes of trypanocides. The effect of compound 4 against L. mexicana promastigotes was irreversible after a 5-h exposure, leading to the sterilization of the culture between 24 and 48 h.
Micro-CT-Based Quantification of Extracted Thrombus Burden Characteristics and Association With Angiographic Outcomes in Patients With ST-Elevation Myocardial Infarction: The QUEST-STEMI Study
Authors: Karagiannidis Efstratios , Papazoglou Andreas S , Sofidis Georgios , Chatzinikolaou Evangelia , Keklikoglou Kleoniki , Panteris Eleftherios , Kartas Anastasios , Stalikas Nikolaos , Zegkos Thomas , Girtovitis Fotios , Moysidis Dimitrios V. , Stefanopoulos Leandros , Koupidis Kleanthis , Hadjimiltiades Stavros , Giannakoulas George , Arvanitidis Christos , Michaelson James S. , Karvounis Haralambos , Sianos Georgios 
Published: April 2021

Background: Angiographic detection of thrombus in STEMI is associated with adverse outcomes. However, routine thrombus aspiration failed to demonstrate the anticipated benefit. Hence, management of high coronary thrombus burden remains challenging. We sought to assess for the first time extracted thrombotic material characteristics utilizing micro-computed tomography (micro-CT).Methods: One hundred thirteen STEMI patients undergoing thrombus aspiration were enrolled. Micro-CT was undertaken to quantify retrieved thrombus volume, surface, and density. Correlation of these indices with angiographic and electrocardiographic outcomes was performed.Results: Mean aspirated thrombus volume, surface, and density (±standard deviation) were 15.71 ± 20.10 mm3, 302.89 ± 692.54 mm2, and 3139.04 ± 901.88 Hounsfield units, respectively. Aspirated volume and surface were significantly higher (p &lt; 0.001) in patients with higher angiographic thrombus burden. After multivariable analysis, independent predictors for thrombus volume were reference vessel diameter (RVD) (p = 0.011), right coronary artery (RCA) (p = 0.039), and smoking (p = 0.027), whereas RVD (p = 0.018) and RCA (p = 0.019) were predictive for thrombus surface. Thrombus volume and surface were independently associated with distal embolization (p = 0.007 and p = 0.028, respectively), no-reflow phenomenon (p = 0.002 and p = 0.006, respectively), and angiographically evident residual thrombus (p = 0.007 and p = 0.002, respectively). Higher thrombus density was correlated with worse pre-procedural TIMI flow (p &lt; 0.001). Patients with higher aspirated volume and surface developed less ST resolution (p = 0.042 and p = 0.023, respectively).Conclusions: Angiographic outcomes linked with worse prognosis were more frequent among patients with larger extracted thrombus. Despite retrieving larger thrombus load in these patients, current thrombectomy devices fail to deal with thrombotic material adequately. Further studies of novel thrombus aspiration technologies are warranted to improve patient outcomes.Clinical Trial Registration: QUEST-STEMI trial ClinicalTrials.gov number: NCT03429608 Date of registration: February 12, 2018. The study was prospectively registered.
Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline
Authors: Hansen Niels , Singh Aditya , Bartels Claudia , Brosseron Frederic , Buerger Katharina , Cetindag Arda C. , Dobisch Laura , Dechent Peter , Ertl-Wagner Birgit B. , Fliessbach Klaus , Haynes John D. , Heneka Michael T. , Janowitz Daniel , Kilimann Ingo , Laske Christoph , Metzger Coraline D. , Munk Matthias H. , Peters Oliver , Priller Josef , Roy Nina , Scheffler Klaus , Schneider Anja , Spottke Annika , Spruth Eike J. , Teipel Stefan , Tscheuschler Maike , Vukovich Ruth , Wiltfang Jens , Duezel Emrah , Jessen Frank , Goya-Maldonado Roberto 
Published: April 2021

Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases.Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups.Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode.Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.
Children With Inflammatory Bowel Disease in the COVID-19 Main Endemic Focus: The Lombardy Experience
Authors: Sansotta Naire , Norsa Lorenzo , Zuin Giovanna , Panceri Roberto , Dilillo Dario , Pozzi Elena , Giacomo Costantino De , Moretti Chiara , Celano Rosaria , Nuti Federica , Sgaramella Paola , Stefano Marina Di , Salvatore Silvia , Arrigo Serena , Motta Valentina , D'Antiga Lorenzo 
Published: April 2021

Objectives: In the era of Coronavirus 2019 (COVID-19), concern has been raised for immunosuppressed patients, including children with inflammatory bowel diseases (IBD). We aimed to collect data from IBD tertiary centers of Lombardy during pandemic.Methods: A cross-sectional survey enrolling IBD children has been completed by seven major IBD centers in Lombardy during lockdown. The clinical form included questions on any symptom consistent with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the IBD adherence treatment. Furthermore, we have reviewed all IBD medical records including new IBD diagnoses and flares in known IBD patients after the lockdown.Results: Questionnaires of 290 IBD children were returned during lockdown. Out of them, 24 children (8%) complained of mild symptoms suspicious of SARS-CoV-2 infection without needing hospitalization or changing IBD treatment. During the lockdown, one patient presented with IBD flare and one had infectious colitis, with no new IBD cases. Conversely, after lockdown, 12/290 (4%) children relapsed and 15 children were newly diagnosed with IBD. Last year, in the same timeframe, 20/300 (7%) children presented with IBD flare, while 17 children had IBD onset with no statistical difference.Conclusions: Our data on children with IBD in a high COVID-19 prevalence region are reassuring. Only a minority of IBD children had mild symptoms, and no hospitalization or treatment modification was needed. Standard IBD treatments including biologics were safely continued. New IBD diagnoses and flares in known IBD children occurred after the lockdown phase, although no significant difference was found compared with the previous year.
The Association Between Locus of Control and Psychopathology: A Cross-Cohort Comparison Between a UK (Avon Longitudinal Study of Parents and Children) and a Japanese (Tokyo Teen Cohort) Cohort
Authors: Sullivan Sarah , Yamasaki Syudo , Ando Shuntaro , Endo Kaori , Kasai Kiyoto , Culpin Iryna , Dardani Christina , Zammit Stanley , Nishida Atsushi 
Published: April 2021

Background: An external locus of control (externality) is associated with poorer psychopathology in individualist cultures, but associations are reported to be weaker in collectivist cultures where an external style is less maladaptive. We investigated the prospective association between externality and psychotic-like experiences (PLE) and depressive symptoms (DS) and compared the strength of associations between a UK and a Japanese cohort.Method: Cross-cultural cohort study of a UK (Avon Longitudinal Study of Parents and Children) and a Japanese cohort (Tokyo Teen Cohort). Externality was assessed using the Children's Nowicki and Strickland Internal, External Scale and DS using the Short Moods and Feelings Questionnaire in both cohorts, PLE were assessed with the Psychosis-Like Experiences Questionnaire (ALSPAC), and the Adolescent Psychotic-Like Symptom Screener (TTC). Associations were investigated using multivariable regression models and bivariate regression models to compare the strength of associations.Results: Mean externality in both childhood and adolescence was higher in ALSPAC than in the TTC. Childhood externality was associated with PLE in late childhood and adolescence in both cohorts and adolescent externality was associated with PLE in young adulthood in the ALSPAC cohort. There was a more mixed pattern of association between externality and DS scores. There was little evidence of any differences in the strength of associations between externality and different psychopathologies, or between cohorts. In ALSPAC adolescent externality and early adult psychopathology were more strongly associated than childhood externality and adolescent and early adult psychopathology. There was no evidence that change in externality between childhood and adolescence was associated with new onset PLE or DS in early adulthood.Conclusion: An external locus of control is associated with poor mental health regardless of cultural context.
Emerging Processes Within Peer-Support Hearing Voices Groups: A Qualitative Study in the Dutch Context
Authors: Schaefer Barbara , Boumans Jenny , van Os Jim , van Weeghel Jaap 
Published: April 2021

Purpose/Aims: This study aimed to gain insight into the value of Hearing Voices Groups (HVGs) in the Dutch context. Specifically, we aimed to learn more about the meaning of HVG participation, as well as the aspects that contribute to that meaning, from the perspective of participants' experiences.Method: The study used a qualitative design with in-depth interviews to explore the experiences of 30 members within seven HVGs in the Netherlands. Interviews were recorded, transcribed, and analyzed using interpretative analysis inspired by the Grounded Theory method.Findings: The individual-level analysis revealed four different group processes that appear to determine the value that HVGs have for their participants: (i) peer-to-peer validation, (ii) exchanging information and sharing self-accumulated knowledge, (iii) connection and social support, and (iv) engaging in mutual self-reflection. We found that specific characteristics of HVGs facilitate these group processes and lead to specific personal outcomes. Combining the interview data from people who joined the same HVG reveals that, although all four described group processes occur in all groups, each group's emphasis differs. Three related factors are described: (i) the composition of the group, (ii) the style of the facilitators, and (iii) the interaction between group processes and individual processes.Implications: Unique processes, for which there is little to no place within regular mental health care (MHC), occur within HVGs. MHC professionals should be more aware of the opportunities HVG can offer voice-hearers. Essential matters regarding the implementation of HVGs are discussed.
Effect of Psychoeducation Group Training Based on Problem-Solving Skills for Women Experiencing Bipolar Spouse Abuse
Authors: Seyyedi Nasooh Abad Maryam , Vaghee Saeed , Aemmi Seyedeh Zahra 
Published: April 2021

Aim: Wives of patients with bipolar disorder as informal caregivers are at high risk for spouse abuse and need to learn coping strategies such as problem-solving skills to manage problematic situations. The purpose of this study was to assess the effectiveness of the psychoeducation group training based on problem-solving skills for women experiencing bipolar spouse abuse.Methods: A randomized clinical trial design was used for this study. In intervention group, women experiencing bipolar spouse abuse participated in four problem-solving skills training sessions and women in two groups (intervention = 30 and control = 30) completed the Index of Spouse Abuse at baseline and after 2 months.Results: The results indicated that changes in abuse scores (physical, non-physical and total of Index of Spouse Abuse) after the intervention were significantly different among the two groups (p &lt; 0.0001). Although abuse scores decreased in both the intervention and the control groups, but lower abuse scores in the intervention than control group were statistically significant.Conclusion: Our findings support that the problem-solving skills training intervention can help to decrease the women experience of bipolar spouse abuse.
Is it Worth Starting Sexual Rehabilitation Before Radical Prostatectomy? Results From a Systematic Review of the Literature
Authors: Schoentgen Nadja , Califano Gianluigi , Manfredi Celeste , Romero-Otero Javier , Chun Felix K. H. , Ouzaid Idir , Hermieu Jean-François , Xylinas Evanguelos , Verze Paolo 
Published: April 2021

Background and Purpose: Sexual dysfunction (SD) is a frequent side effect associated with radical prostatectomy (RP) for prostate cancer (PCa). Some studies have showed the benefit associated with preoperative sexual rehabilitation (prehabilitation) and Enhanced Recovery After Surgery (ERAS) for RP, but no clear clinical recommendations are available yet. Our aim was to conduct a systematic review on sexual prehabilitation prior to RP for patients with a localized PCa and analyze the impact on postoperative sexual health compared with the standard post-operative care.Methods: We performed a systematic review of the literature following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) recommendations.Results: Four randomized control trials and one retrospective comparative study were included in the analyses. Three of the five studies showed an improved EF recovery post-RP in the prehabilitation group compared to the standard of care represented by: higher International Index of Erectile Function 5 score (IIEF5) or IIEF score (p &lt; 0.0001) and a higher percentage of patients reporting return of EF based on the Sexual Encounter Profile (SEP) (56 vs. 24%, p = 0.007). Self-confidence, therapeutic alliance, and adherence to treatment were stronger for patients with preoperative consultations (p &lt; 0.05) and EF recovery was better in cases of a higher number of follow-up visits (OR 4–5 visits vs. 1:12.19, p = 0.002).Discussion: Despite heterogenous methods and high risks of bias in this systematic review, starting sexual rehabilitation prior to surgery seems to ensure better EF recovery. This prehabilitation should include information of both the patient and his or her partner, with a closer follow up and the use of a multimodal treatment approach that still remains to be defined and validated (oral medication, vacuum devices, pelvic floor muscle training, etc.).
Potential Prognostic Value of Preoperative Leukocyte Count, Lactate Dehydrogenase and C-Reactive Protein in Thymic Epithelial Tumors
Authors: Valdivia Daniel , Cheufou Danjouma , Fels Benjamin , Puhlvers Stephan , Mardanzai Khaled , Zaatar Mohamed , Weinreich Gerhard , Taube Christian , Theegarten Dirk , Stuschke Martin , Schuler Martin , Stamatis Georgios , Hegedus Balazs , Aigner Clemens 
Published: April 2021

Thymic epithelial tumors are the most common mediastinal tumors. Surgery is the mainstay of treatment and complete resection provides the best survival rate. However, advanced tumors often require multimodality treatment and thus we analyzed the prognostic potential of routine circulating biomarkers that might help to risk-stratify patients beyond tumor stage and histology. Preoperative values for white blood cell count (WBC), C-reactive protein (CRP) and lactate dehydrogenase (LDH) were analyzed in 220 thymic epithelial tumor patients operated between 1999 and 2018. Increased CRP levels (&gt;1 mg/dl) were significantly more often measured in thymic carcinoma and neuroendocrine tumors when compared to thymoma. LDH serum activity was higher in thymic neuroendocrine tumors when compared to thymoma or thymic carcinoma. The median disease specific survival was significantly longer in thymoma cases than in thymic carcinoma and neuroendocrine tumors. Increased preoperative LDH level (&gt;240 U/L) associated with shorter survival in thymus carcinoma (HR 4.76, p = 0.0299). In summary, higher CRP associated with carcinoma and neuroendocrine tumors, while LDH increased primarily in neuroendocrine tumors suggesting that biomarker analysis should be performed in a histology specific manner. Importantly, preoperative serum LDH might be a prognosticator in thymic carcinoma and may help to risk stratify surgically treated patients in multimodal treatment regimens.
Les effets de la dépendance des associations porte-paroles de la francophonie canadienne sur le Gouvernement du Canada
Authors: Charbonneau François 
Published: April 2021

Ce texte porte sur la dynamique particulière de financement des associations porte-paroles de la francophonie canadienne. Les associations porte-paroles de la francophonie canadienne, c’est-à-dire les associations qui parlent au nom des communautés francophones et acadiennes là où ces communautés sont minoritaires (dans tous les provinces et territoires, sauf dans la province de Québec) opèrent dans un régime linguistique particulier qui induit un certain nombre d’effets qui seront ici analysés. Par l’adoption de la Loi sur les langues officielles en 1969, le Canada s’est doté d’un régime linguistique basé sur le principe de la personnalité ne nécessitant pas, du moins de manière théorique, de reconnaissance ni de collectivité ni de droits collectifs. Or, dans la pratique, ses programmes d’appuis aux minorités linguistiques ont une dimension collective affirmée. Depuis près d’une cinquantaine d’années en effet, le Gouvernement du Canada finance le milieu associatif porte-parole des neuf provinces et des trois territoires où les francophones vivent en situation minoritaire. Il s’est même imposé l’obligation, par la partie 7 de la Loi sur les langues officielles, d’assurer la « vitalité » de ces communautés. Le financement du réseau institutionnel porte-parole de la francophonie canadienne fait partie des mesures devant assurer cette vitalité. Il sert notamment de palliatif au faible poids politique de ces communautés, leur permettant d’avoir une voix sur la place publique, devant les tribunaux ou lors de consultations engageant l’avenir de la communauté. Mais la dépendance financière du milieu associatif sur le Gouvernement canadien a aussi des effets négatifs. L’objectif de cet article est triple. Il s’agira d’abord d’expliquer pourquoi le Gouvernement du Canada a jugé nécessaire d’appuyer financièrement les associations porte-paroles de la francophonie canadienne. Sera ensuite chiffrée la dépendance financière du milieu associatif sur le Gouvernement canadien de manière à montrer que ces associations pourraient difficilement exister sans ce financement. Enfin, il s’agira de montrer les effets potentiellement délétères de la dépendance financière des associations porte-paroles de la francophonie canadienne, en expliquant qu’étant donné le contexte particulier dans lequel opère aujourd’hui ces associations, il n’est plus aujourd’hui possible de déterminer « qui parle » quand les associations porte-paroles prennent la parole au nom des communautés francophones du Canada.