bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Tumor Necrosis Factor-Alpha Withdrawal in Children With Inflammatory Bowel Disease in Endoscopic and Histologic Remission
Authors: Scarallo Luca , Bolasco Giulia , Barp Jacopo , Bianconi Martina , di Paola Monica , Di Toma Michele , Naldini Sara , Paci Monica , Renzo Sara , Labriola Flavio , De Masi Salvatore , Alvisi Patrizia , Lionetti Paolo 
Published: April 2021

AbstractBackgroundThe aim of the present study was to investigate outcomes of anti-TNF-alpha (ATA) withdrawal in selected pediatric patients with inflammatory bowel disease who achieved clinical remission and mucosal and histological healing (MH and HH).MethodsA retrospective analysis was performed on children and adolescents affected by Crohn disease (CD) and ulcerative colitis (UC) who were followed up at 2 tertiary referral centers from 2008 through 2018. The main outcome measure was clinical relapse rates after ATA withdrawal.ResultsOne hundred seventy patients received scheduled ATA treatment; 78 patients with CD and 56 patients with UC underwent endoscopic reassessment. We found that MH was achieved by 32 patients with CD (41%) and 30 patients with UC (53.6%); 26 patients with CD (33.3%) and 22 patients with UC (39.3%) achieved HH. The ATA treatment was suspended in 45 patients, 24 affected by CD and 21 by UC, who all achieved concurrently complete MH (Simplified Endoscopic Score for CD, 0; Mayo score, 0, respectively) and HH. All the patients who suspended ATA shifted to an immunomodulatory agent or mesalazine. In contrast, 17 patients, 8 with CD and 9 with UC, continued ATA because of growth needs, the persistence of slight endoscopic lesions, and/or microscopic inflammation. Thirteen out of 24 patients with CD who suspended ATA experienced disease relapse after a median follow-up time of 29 months, whereas no recurrence was observed among the 9 patients with CD who continued treatment (P = 0.05). Among the patients with UC, there were no significant differences in relapse-free survival among those who discontinued ATA and those who did not suspend treatment (P = 0.718).ConclusionsDespite the application of rigid selection criteria, ATA cessation remains inadvisable in CD. In contrast, in UC, the concurrent achievement of MH and HH may represent promising selection criteria to identify patients in whom treatment withdrawal is feasible.
Telemedicine usage via WeChat for children with congenital heart disease preoperatively during COVID-19 pandemic: a retrospective analysis
Authors: Zhang Qi-Liang , Xie Wen-Peng , Lei Yu-Qing , Cao Hua , Chen Qiang 
Published: April 2021

Abstract

Objective
During the COVID-19 pandemic, parents of infants having medical problem face challenges of insufficient medical resources at home. The purpose of this study was to investigate the effect of WeChat-based telehealth services on the preoperative follow-up of infants with congenital heart disease (CHD) during the COVID-19 pandemic.

Methods
This study retrospectively analyzed the medical records of 190 infants with CHD who underwent remote follow-up via WeChat from December 2019 to May 2020 in Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University. In addition, the psychological benefits of WeChat on the parents of these infants were analyzed.

Results
In total, 190 infants were involved in this study, including 72 cases of ventricular septal defects, 42 cases of patent ductus arteriosus, 55 cases of atrial septal defects, 3 cases of tetralogy of Fallot, 2 cases of endocardial cushion defects, 12 cases of pulmonary stenosis, 2 cases of total anomalous pulmonary venous connection and 2 cases of aortic arch constriction. During the follow-up period, 48 infants who received surgical indications were hospitalized in time for surgical treatment. It was recommended that 10 infants with respiratory tract infections be treated in local hospitals through the WeChat platform. We provided feeding guidance to 28 infants with dysplasia through the WeChat platform. The psychological evaluation results of parents showed that the median score and range of Self-Rating Depression Scale scores were 42 and 32–58, respectively. Nine parents (4.7%) were clinically depressed, while the majority had mild depression. The median score and range of Self-Rating Anxiety Scale scores were 44 and 31–59, respectively. Twenty parents (10.5%) had clinical anxiety, while the rest had mild anxiety.

Conclusion
During the COVID-19 pandemic, follow-up management and health services for infants with CHD prior to surgery through the WeChat platform were useful in identifying the state of an infant’s condition as well as in identifying and relieving care pressure, anxiety and depression in the parents.
Behavioral and stress responses to feeding time in pregnant sows under limit-fed regime
Authors: Manu Hayford , Lee Suhyup , Keyes Mike C , Cairns Jim , Baidoo Samuel K 
Published: April 2021

Abstract
We investigated the effect of feeding time on behavior and stress responses in pregnant sows under isocaloric conditions. Twenty-four sows were balanced for parity and randomly assigned to 1 of 3 feeding times. Corn–soybean meal-based diet was fed once at: 0730 (Control, T1), 1130 (T2), and 1530 hours (T3). On average, sows received 7,062 kcal ME/d from 2.20 kg of diet formulated to contain SID Lys/ME of 1.71 g/Mcal. The study was conducted for 28 d (21 d acclimation to the feeding regime and 7 d data collection). Saliva samples were collected every 2 hr for 12 hr in stalls on day 52 of pregnancy. Behavior data were collected 24 hr for 7 d from day 53 of gestating by affixing a remote insights ear tag to each sow. Each sow had 120,960 data points categorized into: “Active,” “Feed,” or “Dormant”. Due to housing constraint, all sows were housed in individual stalls in the same barn presenting a potential limitation of the study. Data were analyzed using PROC MIXED and GLIMMIX procedures of SAS 9.4 for cortisol and behavior data, respectively. Sow was the experimental unit. The area under the curve (AUC) is quantitative evaluation of response as threshold varies over all possible values. A 12-hr cortisol total AUC for sows fed once daily at 1130 hours was reduced relative to sow group fed at 1530 hours (P = 0.046) but similar compared with the control sows (P = 0. 323). The control sows (0730 hours) had reduced total (P &lt; 0.001) and feeding (P = 0.001) activity AUCs relative to sows on 1130 hours but did not differ compared with sows on 1530 hours feeding schedules (P &gt; 0.100). Sows on 1130 hours feeding schedule had greater feed anticipatory activity, 24-hr total activity count, total (P &lt; 0.001) and feeding (P &lt; 0.001) activity AUC compared with sows fed daily at 1530 hours. In conclusion, feeding pregnant sows earlier in the morning (0730 hours) appears to minimize sows’ behavior but similar cortisol response. Sows on 1130 hours feeding schedule had greater activities but reduced cortisol concentration, suggesting that elevated sow activity might not necessarily indicate activation of hypothalamic–pituitary–adrenal axis.
A high-order total-variation regularisation method for full-waveform inversion
Authors: Du Zeyuan , Liu Dingjin , Wu Guochen , Cai Jiexiong , Yu Xin , Hu Guanghui 
Published: April 2021

Abstract
Full-waveform inversion (FWI) is among the most effective methods of velocity modelling in seismic exploration. However, because of the strong nonlinearity of the FWI, if the velocity in the target geobody is not sharply different from that in its surroundings, the total variation (TV) of the model will not be sufficiently sparse. To alleviate this issue, we propose a novel TV-regularised FWI method that can consider the sparsity of the high-order regularisation operator and consequently improve the stability of the inversion process and produce more focused model boundaries. We use a split-Bregman algorithm to solve the inversion optimisation problem while building the TV-regularised objective function. We show that stable model updates can be obtained by this algorithm, which proved to be effective and reliable in the numerical tests. These tests also show that the proposed method converges faster, can model the velocity domain better than conventional methods and can effectively identify layer boundaries with a weak velocity contrast. We conclude that the novel FWI method based on high-order TV regularisation is robust and accurate.
Interpreting the Human Rights Field: A Conversation
Authors: Kunreuther Laura , Acharya Shiva , Hunkins Ann , Karki Sachchi Ghimire , Khadka Hikmat , Sangroula Loknath , Turin Mark , Vasily Laurie 
Published: April 2021

AbstractThis article takes the form of a conversation between an anthropologist and seven interpreters who worked for the UN Office of the High Commissioner for Human Rights (OHCHR) during its mission in Nepal (2005–2011). As any human rights or humanitarian worker knows quite well, an interpreter is essential to any field mission; they are typically the means by which ‘internationals’ are able to speak to any local person. Interpreters make it possible for local events to be transformed into a globally legible register of human rights abuses or cases. Field interpreters are therefore crucial to realizing the global ambitions of any bureaucracy like the UN. Yet rarely do human rights officers or academics (outside of translation studies) hear from interpreters themselves about their experience in the field. This conversation is an attempt to bridge this lacuna directly, in the hope that human rights practitioners and academics might benefit from thinking more deeply about the people upon whom our knowledge often depends.
Guideline adherence for radical cystectomy significantly affects survival outcomes in non-muscle-invasive bladder cancer patients
Authors: Kayama Emina , Shigeta Keisuke , Kikuchi Eiji , Ogihara Koichiro , Hakozaki Kyohei , Iwasawa Tomohiro , Kamisawa Ken , Kanai Kunimitsu , Ide Hiroki , Hara Satoshi , Mizuno Ryuichi , Oya Mototsugu 
Published: April 2021

Abstract

Background
The relationship between guideline adherence for radical cystectomy of non-muscle-invasive bladder cancer and patient prognoses currently remains unclear. We investigated whether guideline adherence at the time of non-muscle-invasive bladder cancer affects the oncological outcomes of bladder cancer patients who underwent radical cystectomy.

Methods
Among 267 cTa-4N0-2M0 bladder cancer patients, 70 who underwent radical cystectomy under the non-muscle-invasive bladder cancer or muscle-invasive bladder cancer status that progressed from non-muscle-invasive bladder cancer were identified. Patients who followed the guidelines from initial transurethral resection of bladder tumors to radical cystectomy were defined as the guideline adherent group (n = 52), while those who did not were the guideline non-adherent group (n = 18).

Results
In the guideline non-adherent group, 8 (44.4%) out of 18 were diagnosed with highest risk non-muscle-invasive bladder cancer for Bacillus Calmette Guérin-naïve patients and 7 (38.9%) had a Bacillus Calmette Guérin unresponsive tumor status. Five-year recurrence-free survival and cancer-specific survival rates for the guideline non-adherent group vs guideline adherent group were 38.9% vs 69.8% (P = 0.018) and 52.7% vs 80.1% (P = 0.006), respectively. A multivariate analysis identified guideline non-adherence as one of independent indicators for disease recurrence (hazard ratio = 2.81, P = 0.008) and cancer-specific death (hazard ratio = 4.04, P = 0.003). In a subgroup analysis of 49 patients with cT1 or less non-muscle-invasive bladder cancer at the time of radical cystectomy, guideline non-adherence remained an independent prognostic factor for cancer-specific survival (hazard ratio = 3.46, P = 0.027).

Conclusions
Guideline adherence during the time course of the non-muscle-invasive bladder cancer stage may result in a favorable prognosis of patients who receive radical cystectomy. Even under non-muscle-invasive bladder cancer status, radical cystectomy needs to be performed with adequate timing under guideline recommendations.
Critical Photoperiod and Its Potential to Predict Mosquito Distributions and Control Medically Important Pests
Authors: Peffers Caitlin S , Pomeroy Laura W , Meuti Megan E 
Published: April 2021

Abstract
Diapause, a period of arrested development that allows mosquitoes to survive inhospitable conditions, is triggered by short daylengths in temperate mosquitoes. Different populations of mosquitoes initiate diapause in response to a specific photoperiod, or daylength, resulting in population-specific differences in annual cycles of abundance. The photoperiod that causes approximately 50% of a population to initiate diapause is known as the critical photoperiod (CPP). The autumn daylength corresponding to the CPP in the field likely marks the day beyond which the photoperiods would trigger and maintain 50% or more diapause incidence in a population, although temperature, diet, and other factors can impact diapause initiation. In the Northern Hemisphere, northern populations of mosquitoes experience lower temperatures earlier in the year and must be triggered into diapause by longer daylengths than southern populations. CPP is genetically based, but also adapts over time responding to the population’s environment. Therefore, CPP has been shown to lengthen with increasing latitude and altitude. While the positive correlation between CPP and latitude/altitude has been established in a few mosquito species, including Aedes albopictus (Skuse, Diptera: Culicidae), Aedes triseriatus, Aedes sierrensis, and Wyeomyia smithii (Coquillett, Diptera: Culicidae), we do not know when most other species initiate their seasonal responses. As several of these species transmit important diseases, characterizing the CPP of arthropod vectors could improve existing control by ensuring that surveillance efforts align with the vector’s seasonally active period. Additionally, better understanding when mosquitoes and other vectors initiate diapause can reduce the frequency of chemical applications, thereby ameliorating the negative impacts to nontarget insects.
Numerical convergence of hot-Jupiter atmospheric flow solutions
Authors: Skinner J W , Cho J Y-K 
Published: April 2021

ABSTRACT
We perform an extensive study of numerical convergence for hot-Jupiter atmospheric flow solutions in simulations employing a setup commonly used in extrasolar planet studies – a resting state thermally forced to a prescribed temperature distribution on a short time-scale at high altitudes. Convergence is assessed rigorously with (i) a highly accurate pseudospectral model that has been explicitly verified to perform well under hot-Jupiter flow conditions and (ii) comparisons of the kinetic energy spectra, instantaneous (unaveraged) vorticity fields and temporal evolutions of the vorticity field from simulations that are numerically equatable. In the simulations, the (horizontal as well as vertical) resolution, dissipation operator order, and viscosity coefficient are varied with identical physical and initial setups. All of the simulations are compared against a fiducial reference simulation at high horizontal resolution and dissipation order (T682 and ∇ 16, respectively) – as well as against each other. Broadly, the reference solution features a dynamic, zonally (east–west) asymmetric jet with a copious amount of small-scale vortices and gravity waves. Here, we show that simulations converge to the reference simulation only at T341 resolution and with ∇ 16 dissipation order. Below this resolution and order, simulations either do not converge or converge to unphysical solutions. The general convergence behaviour is independent of the vertical range of the atmosphere modelled, from $\sim 2 \times 10^{-3}$MPa to   $\sim 2 \times 10^1$ MPa. Ramifications for current extrasolar planet atmosphere modelling and observations are discussed.
Magnetohydrodynamic convection in accretion discs
Authors: Held Loren E , Latter Henrik N 
Published: April 2021

ABSTRACT
Convection has been discussed in the field of accretion discs for several decades, both as a means of angular momentum transport and also because of its role in controlling discs’ vertical structure via heat transport. If the gas is sufficiently ionized and threaded by a weak magnetic field, convection might interact in non-trivial ways with the magnetorotational instability (MRI). Recently, vertically stratified local simulations of the MRI have reported considerable variation in the angular momentum transport, as measured by the stress to thermal pressure ratio α, when convection is thought to be present. Although MRI turbulence can act as a heat source for convection, it is not clear how the two instabilities will interact dynamically. Here, we investigate their interplay in controlled numerical experiments and isolate the generic features of their interactions. We perform vertically stratified, 3D magnetohydrodynamic shearing box simulations with a perfect gas equation of state with the conservative, finite-volume code pluto. We find two characteristic outcomes of the interaction between the two instabilities: (a) straight MRI and (b) MRI/convective cycles, with the latter exhibiting alternating phases of convection-dominated and MRI-dominated flow. During the latter phase, we find that α is enhanced by nearly an order of magnitude, reaching peak values of ∼0.08. In addition, we find that convection in the non-linear phase takes the form of large-scale and oscillatory convective cells. Convection can also help the MRI persist to lower Rm than it would otherwise do. Finally, we discuss how our results help interpret simulations of dwarf novae.
Interacting galaxies in the IllustrisTNG simulations – III. (The rarity of) quenching in post-merger galaxies
Authors: Quai Salvatore , Hani Maan H , Ellison Sara L , Patton David R , Woo Joanna 
Published: April 2021

ABSTRACT
Galaxy mergers are traditionally one of the favoured mechanisms for the transformation of spiral galaxies to spheroids and for quenching star formation. To test this paradigm in the context of modern cosmological simulations, we use the IllustrisTNG simulation to investigate the impact of individual merger events on quenching star formation [i.e. star formation rate (SFR) at least 3σ below the star-forming main sequence] within 500 Myr after the coalescence phase. The rate of quenching amongst recently merged galaxies is compared with a control sample that is matched in redshift, stellar mass, SFR, black hole mass, and environment. We find quenching to be uncommon among the descendants of post-merger galaxies, with only ${\sim} 5{{\ \rm per\ cent}}$ of galaxies quenching within 500 Myr after the merger. Despite this low absolute rate, we find that quenching occurs in post-mergers at twice the rate of the control galaxies. The fraction of quenched post-merger descendants 1.5 Gyr after the merger become statistically indistinguishable from that of non-post-mergers, suggesting that mergers could speed up the quenching process in those post-mergers whose progenitors had physical conditions able to sustain effective active galactic nuclei (AGN) kinetic feedback, thus capable of removing gas from galaxies. Our results indicate that although quenching does not commonly occur promptly after coalescence, mergers none the less do promote the cessation of star formation in some post-mergers. We find that, in IllustrisTNG, it is the implementation of the AGN kinetic feedback that is responsible for quenching post-mergers, as well as non-post-merger controls. As a result of the released kinetic energy, galaxies experience gas loss and eventually they will quench. Galaxies with an initially low gas fraction show a preferable pre-disposition towards quenching. The primary distinguishing factor between quenched and star-forming galaxies is gas fraction, with a sharp boundary at fgas ∼ 0.1 in TNG.
Vestiges of the Bacterial Signal Recognition Particle-Based Protein Targeting in Mitochondria
Authors: Pyrih Jan , Pánek Tomáš , Durante Ignacio Miguel , Rašková Vendula , Cimrhanzlová Kristýna , Kriegová Eva , Tsaousis Anastasios D , Eliáš Marek , Lukeš Julius 
Published: April 2021

AbstractThe main bacterial pathway for inserting proteins into the plasma membrane relies on the signal recognition particle (SRP), composed of the Ffh protein and an associated RNA component, and the SRP-docking protein FtsY. Eukaryotes use an equivalent system of archaeal origin to deliver proteins into the endoplasmic reticulum, whereas a bacteria-derived SRP and FtsY function in the plastid. Here we report on the presence of homologs of the bacterial Ffh and FtsY proteins in various unrelated plastid-lacking unicellular eukaryotes, namely Heterolobosea, Alveida, Goniomonas, and Hemimastigophora. The monophyly of novel eukaryotic Ffh and FtsY groups, predicted mitochondrial localization experimentally confirmed for Naegleria gruberi, and a strong alphaproteobacterial affinity of the Ffh group, collectively suggest that they constitute parts of an ancestral mitochondrial signal peptide-based protein-targeting system inherited from the last eukaryotic common ancestor, but lost from the majority of extant eukaryotes. The ability of putative signal peptides, predicted in a subset of mitochondrial-encoded N. gruberi proteins, to target a reporter fluorescent protein into the endoplasmic reticulum of Trypanosoma brucei, likely through their interaction with the cytosolic SRP, provided further support for this notion. We also illustrate that known mitochondrial ribosome-interacting proteins implicated in membrane protein targeting in opisthokonts (Mba1, Mdm38, and Mrx15) are broadly conserved in eukaryotes and nonredundant with the mitochondrial SRP system. Finally, we identified a novel mitochondrial protein (MAP67) present in diverse eukaryotes and related to the signal peptide-binding domain of Ffh, which may well be a hitherto unrecognized component of the mitochondrial membrane protein-targeting machinery.
Development of a TaqMan PCR assay for the identification of the non-native copepodAcartia tonsa, and detection of this species in Norwegian coastal waters
Authors: Moseid Camilla V S , Falkenhaug Tone , Slettan Audun 
Published: April 2021

AbstractMolecular based assays for detection of species are a powerful tool to supplement morphological methods that may be time and labor intensive. Here we describe a sensitive TaqMan real time polymerase chain reaction assay that specifically detects the presence of Acartia tonsa in mixed plankton samples. The assay is used to find this non-native copepod in samples collected in Norwegian coastal waters.
Persistent Blessings of Luck: Theory and an Application to Venture Capital
Authors: Cong Lin William , Xiao Yizhou 
Published: April 2021

Abstract
Persistent performance in venture capital is routinely interpreted as evidence for skill. We present a dynamic model of delegated investment with endogenous fund heterogeneity and deal flow, which generates performance persistence without skill differences and predicts mean reversion in long-term performance. Investors working with multiple funds use contingent payments and tiered contracts to induce proper project nurturing and managerial effort. Successful funds receive continuation contracts that tolerate investment failure and encourage innovation, and subsequently finance entrepreneurs through a path-dependent assortative matching favoring incumbents. Recent empirical findings corroborate the model’s general implications, and the economic mechanisms are robust to short-term contracting, endogenous bargaining, and double moral hazard issues.