bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low pan-immune-inflammation-value predicts better chemotherapy response and survival in breast cancer patients treated with neoadjuvant chemotherapy
Authors: Şahin Ahmet Bilgehan , Cubukcu Erdem , Ocak Birol , Deligonul Adem , Oyucu Orhan Sibel , Tolunay Sahsine , Gokgoz Mustafa Sehsuvar , Cetintas Sibel , Yarbas Gorkem , Senol Kazım , Goktug Mehmet Refik , Yanasma Zeki Burak , Hasanzade Ulviyya , Evrensel Turkkan 
Published: July 2021

AbstractBlood-based biomarkers reflect systemic inflammation status and have prognostic and predictive value in solid malignancies. As a recently defined biomarker, Pan-Immune-Inflammation-Value (PIV) integrates different peripheral blood cell subpopulations. This retrospective study of collected data aimed to assess whether PIV may predict the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in Turkish women with breast cancer. The study consisted of 743 patients with breast cancer who were scheduled to undergo NAC before attempting cytoreductive surgery. A pre-treatment complete blood count was obtained in the two weeks preceding NAC, and blood-based biomarkers were calculated from absolute counts of relevant cell populations. The pCR was defined as the absence of tumor cells in both the mastectomy specimen and lymph nodes. Secondary outcome measures included disease-free survival (DFS) and overall survival (OS). One hundred seven patients (14.4%) had pCR. In receiver operating characteristic analysis, optimal cut-off values for the neutrophile-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte (PLR), PIV, and Ki-67 index were determined as ≥ 2.34, ≥ 0.22, ≥ 131.8, ≥ 306.4, and  ≥ 27, respectively. The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses. However, multivariate analysis revealed that the clinical T stage, PIV, ER status, HER-2 status, and Ki-67 index were independent predictors for pCR. Moreover, the low PIV group patients had significantly better DFS and OS than those in the high PIV group (p = 0.034, p = 0.028, respectively). Based on our results, pre-treatment PIV seems as a predictor for pCR and survival, outperforming NLR, MLR, PLR in predicting pCR in Turkish women with breast cancer who received NAC. However, further studies are needed to confirm our findings.
Enhanced sunlight photocatalytic activity and biosafety of marine-driven synthesized cerium oxide nanoparticles
Authors: Safat Somayeh , Buazar Foad , Albukhaty Salim , Matroodi Soheila 
Published: July 2021

AbstractThis contribution presents the biosynthesis, physiochemical properties, toxicity and photocatalytic activity of biogenic CeO2NPs using, for the first time, marine oyster extract as an effective and rich source of bioreducing and capping/stabilizing agents in a one-pot recipe. CeO2NPs formation was initially confirmed through the color change from light green to pale yellow and subsequently, their corresponding absorption peak was spectroscopically determined at 310 nm with an optical band-gap of 4.67 eV using the DR-UV technique. Further, XRD and Raman analyses indicated that nanoceria possessed face-centered cubic arrangements without any impurities, having an average crystallite size of 10 nm. TEM and SEM results revealed that biogenic CeO2NPs was approximately spherical in shape with a median particle size of 15 ± 1 nm. The presence of various bioorganic substances on the surface of nanoparticles was deduced by FTIR and TGA results. It is found that marine-based nanoceria shows no cytotoxic effect on the normal cell, thus indicating their enhanced biocompatibility and biosafety to living organisms. Environmentally, due to energy band gap, visible light-activated CeO2 nanocatalyst revealed superior photocatalytic performance on degradation of methylene blue pollutant with removal rate of 99%. Owing to the simplicity, cost-effectiveness, and environmentally friendly nature, this novel marine biosynthetic route paves the way for prospective applications of nanoparticles in various areas.
PERK mediates resistance to BRAF inhibition in melanoma with impaired PTEN
Authors: Qin Yifei , Zuo Qiang , Huang Lei , Huang Liping , Merlino Glenn , Yu Yanlin 
Published: July 2021

AbstractTargeting mutant BRAF in patients with melanomas harboring this oncogene has been highly successful as a first-line treatment, but other mutations may affect its efficacy and alter the route of acquired resistance resulting in recurrence and poor prognosis. As an evolving strategy, melanoma treatment needs to be expanded to include targets based on newly discovered emerging molecules and pathways. We here show that PERK plays a critical role in BRAF inhibitor-acquired resistance in melanoma with impaired PTEN. Inhibition of PERK by either shRNA or a pharmacological inhibitor blocked the growth of BRAF inhibitor-resistant melanoma with impaired PTEN in vitro and in vivo, suggesting an effective approach against melanomas with mutant BRAF and PTEN deficiency. Our current findings, along with our previous discovery that the AXL/AKT axis mediates resistance to BRAF inhibition in melanoma with wild-type PTEN, provide new insights toward a strategy for combating BRAF inhibition-acquired resistance in BRAF mutant melanoma with different PTEN statuses.
An Error Analysis of Nonword Repetition Performance in Toddlers and Young Children: Theoretical Implications and Clinical Utility
Authors: Harwood Vanessa , Arthur Dana 
Published: July 2021

Purpose
Nonword repetition has been cited as a measure of phonological working memory and continues to gain status as a clinical tool used to identify language impairment in school-age children. Less is known about nonword repetition skills in the toddler population.

Method
The current study presents a detailed analysis of errors by segmenting nonwords into word, syllable, and phoneme levels. Errors were also analyzed for type (e.g., addition, substitution, deletion). The Test of Early Nonword Repetition was used to measure performance in a sample of 36 typically developing children, aged 24–48 months. Clinical assessments including parent report, language sampling procedures, and standardized assessments were also administered.

Results
As a group, participants produced significantly more syllable errors compared to word-level errors; however, most errors were made at the phoneme level. Errors of addition were the least common error type, and no differences between substitutions or deletions were present for the entire sample. Toddlers (aged 2 years) produced more syllable-level errors compared to older children (aged 3 years). Substitution errors were positively correlated with performance on clinical measures of language, whereas deletion errors were negatively correlated with performance.

Conclusion
Nonword repetition performance patterns in young children may be associated with language delay or language impairment and have both clinical and theoretical relevance.
Advances in space quantum communications
Authors: Sidhu Jasminder S. , Joshi Siddarth K. , Gündoğan Mustafa , Brougham Thomas , Lowndes David , Mazzarella Luca , Krutzik Markus , Mohapatra Sonali , Dequal Daniele , Vallone Giuseppe , Villoresi Paolo , Ling Alexander , Jennewein Thomas , Mohageg Makan , Rarity John G. , Fuentes Ivette , Pirandola Stefano , Oi Daniel K. L. 
Published: July 2021

AbstractConcerted efforts are underway to establish an infrastructure for a global quantum Internet to realise a spectrum of quantum technologies. This will enable more precise sensors, secure communications, and faster data processing. Quantum communications are a front‐runner with quantum networks already implemented in several metropolitan areas. A number of recent proposals have modelled the use of space segments to overcome range limitations of purely terrestrial networks. Rapid progress in the design of quantum devices have enabled their deployment in space for in‐orbit demonstrations. We review developments in this emerging area of space‐based quantum technologies and provide a roadmap of key milestones towards a complete, global quantum networked landscape. Small satellites hold increasing promise to provide a cost effective coverage required to realise the quantum Internet. The state of art in small satellite missions is reviewed and the most current in‐field demonstrations of quantum cryptography are collated. The important challenges in space quantum technologies that must be overcome and recent efforts to mitigate their effects are summarised. A perspective on future developments that would improve the performance of space quantum communications is included. The authors conclude with a discussion on fundamental physics experiments that could take advantage of a global, space‐based quantum network.
Model for the long and orbital brightness variability of the β Lyrae type binary OGLE-BLG-ECL-157529
Authors: Mennickent R. E. , Djurašević G. 
Published: July 2021

Context. Some close binaries of the β Lyrae type show photometric cycles longer than the orbital one, which are possibly related to changes in their accretion disks.
Aims. We aim to understand the short- and long-scale morphologic changes observed in the light curve of the eclipsing system OGLE-BLG-ECL-157529. In particular, we want to shed light on the contribution of the disk variability to these changes, especially those related to the long cycle, occurring on timescales of hundreds of days.
Methods. We studied I-band Optical Gravitational Lensing Experiment (OGLE) photometric times series spanning 18.5 years, constructing disk models by analyzing the orbital light curve at 52 different consecutive epochs. An optimized simplex algorithm was used to solve the inverse problem by adjusting the light curve with the best stellar-orbital-disk parameters for the system. We applied an analysis of principal components to the parameters to evaluate their dependence and variability. We constructed a description of the mass transfer rate in terms of disk parameters.
Results. We find that the overall light variability can be understood in terms of a variable mass transfer rate and variable accretion disk. The system brightness at orbital phase 0.25 follows the long cycle and is correlated with the mass transfer rate and the disk thickness. The long-cycle brightness variations can be understood in terms of differential occultation of the hotter star by a disk of variable thickness. Our model fits the overall light curve during 18.5 years well, including epochs of reversal of main and secondary eclipse depths. The disk radius cyclically change around the tidal radius, decoupled from changes in the mass transfer rate or system brightness, suggesting that viscous delay might explain the non-immediate response. Although the disk is large and fills a large fraction of the hot star Roche lobe, Lindblad resonance regions are far beyond the disk, excluding viscous dissipation as a major source of photometric variability.
Statements der 5 Mitglieder von OMT-Deutschland
Authors: Bretschneider Susan , Thiel Martin , Petzold Ronny , Pfäffle Uta , Zöller Matthias , Davies-Knorr Trisha , Baumgärtner Sandra , von Piekartz Harry 
Published: July 2021

„Hands-on!“ heißt der Schwerpunkt dieser Ausgabe der MSK, in der Hands-on/Hands-off- Herangehensweisen debattiert werden. Arne Vielitz und Dr. Claus Beyerlein, beide Herausgeber der MSK, baten daher Vertreter/-innen der 5 Mitglieder der Dachorganisation OMT-Deutschland um ein Statement zu folgenden Fragen: Was beinhaltet die muskuloskelettale Physiotherapie für Sie? Wie sieht eine gelungene/zeitgemäße praktische Umsetzung/Anwendung aus? Wie sehen Sie die muskuloskelettale Physiotherapie in der Zukunft? Wo geht die Reise hin?Die Statements der 5 auf diese Fragen sind in alphabetischer Reihenfolge geordnet.
Research and experimental verification of the characteristics of asymmetric multi-stage fluid guiding body piezoelectric pump
Authors: He Lipeng , Zhang Zheng , Zhou Jianwen , Hu Dianbin , Hou Yi , Li Qinggang , Cheng Guangming 
Published: July 2021

Valveless piezoelectric pumps usually have less flow than valve piezoelectric pumps, but the valve piezoelectric pumps have some limitations, such as high cost, complex structure, and difficult installation. In order to solve the problem of the low flow rate of the valveless piezoelectric pump, a valveless piezoelectric pump with multi-stage fluid guiding bodies is proposed. Based on the structure and working principle of the piezoelectric pump, the forward energy loss equation is established, and analysis on parameters affecting the energy loss of the pump is then conducted. COMSOL Multiphysics is adopted to construct a two-dimensional model of velocity and von Mises stress distribution. The valveless piezoelectric pumps were then fabricated based on 3D printing technologies, and the prototypes were tested. The results show that the output performance of the pump is the best when the working voltage is 220 V, the frequency is 95 Hz, the length of the oblique arm of the fluid guiding body is 3.5 mm, the spacing is 9.05 mm, and the thickness is 0.1 mm. The maximum flow rate is 520.6 ml/min. In addition, the experimental results prove that the asymmetric fluid guiding body placed in the center of the pump chamber can improve the performance of piezoelectric pumps. This study extends the application of piezoelectric valveless pumps in micromechanical cooling.
Tracking the impacts of El Niño drought and fire in human-modified Amazonian forests
Authors: Berenguer Erika , Lennox Gareth D. , Ferreira Joice , Malhi Yadvinder , Aragão Luiz E. O. C. , Barreto Julia Rodrigues , Del Bon Espírito-Santo Fernando , Figueiredo Axa Emanuelle S. , França Filipe , Gardner Toby Alan , Joly Carlos A. , Palmeira Alessandro F. , Quesada Carlos Alberto , Rossi Liana Chesini , de Seixas Marina Maria Moraes , Smith Charlotte C. , Withey Kieran , Barlow Jos 
Published: July 2021

SignificanceAmazonia is experiencing an increase in the frequency of extreme droughts and wildfires. However, the duration of their impacts on plant mortality and carbon stocks are poorly known, and it is unclear whether impacts are amplified in forests with a history of previous human disturbance. We show that plant mortality rates remain above baseline levels for over 3 y in forests affected by drought and 2.5 y in forests affected by both drought and fire. A history of human disturbance led to greater plant mortality in forests simultaneously affected by drought and fire. Our assessment of an area covering 1.2% of the Brazilian Amazon shows that regional drought and fires can have globally relevant impacts on the world’s carbon balance.
Insect-mediated apparent competition between mammals in a boreal food web
Authors: Labadie Guillemette , McLoughlin Philip D. , Hebblewhite Mark , Fortin Daniel 
Published: July 2021

SignificanceDespite the growing recognition that indirect interactions within species networks can determine food web dynamics, empirical evidence remains rare. We demonstrate how the impact of insects on forest structure and composition can reverberate across trophic levels by altering apparent competition in a large-mammal food web subjected to timber extraction. Spruce budworm outbreaks initiated a flush in deciduous vegetation that benefited moose, which translated into apparent competition between moose and boreal caribou through wolf predation. Mortality risk of caribou became indirectly related to patterns of insect and human activities, with the ungulate experiencing higher risk when selecting stands severely infested by budworms and subsequently logged. We expose cascading effects of insect–forest interactions on large-mammal relations in human-altered ecosystems.
Achieving industrial ammonia synthesis rates at near-ambient conditions through modified scaling relations on a confined dual site
Authors: Wang Tao , Abild-Pedersen Frank 
Published: July 2021

Significance
The Haber–Bosch process is of significance in producing fertilizer for agricultural needs and to avoid worldwide mass starvation. Designing a state-of-the-art catalyst to achieve a mild-condition Haber–Bosch process represents a great challenge because it consumes 1 to 2% of annual energy usage worldwide. We propose a theoretical strategy with a confined dual site to achieve an ammonia synthesis rate two to three orders of magnitude higher than the commercial Ru catalyst under the same reaction conditions. This work will open pathways for developing catalysts for the Haber–Bosch process that can operate under milder conditions.
Contrastive semantics of human locomotion verbs
Authors: Kudrnáčová Naděžda 
Published: July 2021

Abstract
This paper is a contribution to a hitherto unexplored area in English-Czech contrastive semantics. It examines
differences in the construal of walking, the most prototypical type of human locomotion. Based on the data from
InterCorp, a synchronic parallel translation corpus, it presents a cognitive oriented analysis of the
semantics of English walk and its nearest Czech counterparts, i.e. jít and
kráčet. Despite their apparent commonalities, the verbs in question do not construe walking in the same way.
In contrast to jít, the construal of a motion situation in walk and kráčet
involves focus on leg movements and bodily position, amounting to a marked segmentation of the motion into individual quanta.
Focus on leg movements and verticality of the body is even more pronounced in kráčet, which can then serve an
evaluative function; such a possibility is not open for walk. Walk thus occupies an intermediate position between
the two verbs.
The near-synonymy of classifiers and construal operation
Authors: Dosedlová Aneta , Lu Wei-lun 
Published: July 2021

Abstract
This paper investigates the near-synonymy of classifiers, using Chinese kē and
zhū as illustration. We find that in [quantifier] – [classifier] – [noun], the two classifiers have
overlapping semantic prototypes due to their similar behavioral profiles. However, despite a shared functional core, the two
classifiers diverge in terms of which part of plant to profile. In particular, zhū highlights parts of
plant that are small and vulnerable, such as flowers and seedlings. In addition, small is another important
conceptual characteristic exclusively associated with zhū, which gives it a distinctive set of peripheral members
to include in that particular linguistic category, including mold, bacterium, and even biological and
chemical substance. Another important difference is the quantifier that precedes, where kē tends to
occur with lower numbers (typically under 10), while zhū with higher numbers (typically over 1,000). Accordingly,
we conclude that [quantifier] – [zhu] – [noun] tends to invoke a higher-resolution construal.
Translator autonomy in the age of behavioural data
Authors: Nunes Vieira Lucas , Ragni Valentina , Alonso Elisa 
Published: July 2021

Abstract
Translation behaviour is increasingly tracked to benchmark productivity, to calculate pay or to automate project
management decisions. Although in many cases these practices are commonplace, their effects are surprisingly under-researched.
This article investigates the consequences of activity tracking in commercial translation. It reports on a series of focus-group
interviews involving sixteen translators who used productivity tools to independently monitor their work for a period of sixteen
weeks. Our analysis revealed several ways in which the act of tracking activity can itself influence translators’ working
practices. We examine translators’ conceptualisations of productivity and discuss the findings as a matter of translator autonomy.
The article calls for further awareness of individual and collective consequences of monitoring translation behaviour. Although in
some contexts translators found activity tracking to be useful, we argue that client-controlled tracking and translator autonomy
are in most cases incompatible.
Stripe-yz magnetic order in the triangular-lattice antiferromagnet KCeS2
Authors: Kulbakov Anton A , Avdoshenko Stanislav M , Puente-Orench Inés , Deeb Mahmoud , Doerr Mathias , Schlender Philipp , Doert Thomas , Inosov Dmytro S 
Published: July 2021

Abstract
Yb- and Ce-based delafossites were recently identified as effective spin-1/2 antiferromagnets on the triangular lattice. Several Yb-based systems, such as NaYbO2, NaYbS2, and NaYbSe2, exhibit no long-range order down to the lowest measured temperatures and therefore serve as putative candidates for the realization of a quantum spin liquid. However, their isostructural Ce-based counterpart KCeS2 exhibits magnetic order below T
N = 400 mK, which was so far identified only in thermodynamic measurements. Here we reveal the magnetic structure of this long-range ordered phase using magnetic neutron diffraction. We show that it represents the so-called ‘stripe-yz’ type of antiferromagnetic order with spins lying approximately in the triangular-lattice planes orthogonal to the nearest-neighbor Ce–Ce bonds. No structural lattice distortions are revealed below T
N, indicating that the triangular lattice of Ce3+ ions remains geometrically perfect down to the lowest temperatures. We propose an effective Hamiltonian for KCeS2, based on a fit to the results of ab initio calculations, and demonstrate that its magnetic ground state matches the experimental spin structure.
Waves in strongly nonlinear Gardner-like equations on a lattice
Authors: Rosenau Philip , Pikovsky Arkady 
Published: July 2021

Abstract
We introduce and study a family of lattice equations which may be viewed either as a strongly nonlinear discrete extension of the Gardner equation, or a non-convex variant of the Lotka–Volterra chain. Their deceptively simple form supports a very rich family of complex solitary patterns. Some of these patterns are also found in the quasi-continuum rendition, but the more intriguing ones, like interlaced pairs of solitary waves, or waves which may reverse their direction either spontaneously or due a collision, are an intrinsic feature of the discrete realm.
Green’s function approach to the Bose–Hubbard model with disorder
Authors: Souza R S , Pelster Axel , Santos F E A dos 
Published: July 2021

Abstract
We analyse the distinction between the three different ground states presented by a system of spinless bosons with short-range interactions submitted to a random potential using the disordered Bose–Hubbard model. The criteria for identifying the superfluid, the Mott-insulator, and the Bose-glass phases at finite temperatures are discussed for small values of the kinetic energy associated with the tunnelling of particles between potential wells. Field theoretical considerations are applied in order to construct a diagrammatic hopping expansion to the finite-temperature Green’s function. By performing a summation of subsets of diagrams we are able to find the condition to the long-range correlations which leads to the phase boundary between superfluid and insulating phases. The perturbative expression to the local correlations allows us to calculate an approximation to the single-particle density of states of low-energy excitations in the presence of small hopping, which characterizes unambiguously the distinction between the Mott-insulator and the Bose-glass phases. We obtain the phase diagram for bounded on-site disorder. It is demonstrated that our analysis is capable of going beyond the mean-field theory results for the classification of these different ground states.