bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kepribadian dan Aktualisasi Diri Unyil dalam Petualangan Si Unyil
Authors: Purna Prayoga Adi , Pusposari Dewi 
Published: June 2021

Abstract: This present study aims at describing the personality and self-actualization of Unyil in the animation video of The Adventures of Si Unyil. This is a descriptive qualitative study in which the personality of Unyil was analyzed using Sigmund Freud’s psychoanalysis theory with the theory specifying id, ego, and superego. Meanwhile, the self-actualization of Unyil was explored using Abraham Maslow’s hierarchy of need with the needs consisting of physiological, safety, social, self-conception, and self-actualization. The data were elicited via a number of methods, including observation, transcription, and note-taking. The collected data were then analyzed using the chosen theories. The key findings of this study indicate that Unyil embraces a good personality by helping others, conforming to the acceptable norms, competitive, and selfless. However, at some point, he is also selfish and likes to tease his friends. With respect to self-actualization, it can be said that Unyil can generally fulfill his needs. The needs he cannot fulfill were not all due to his mistakes.
Kata kunci: Unyil, personality, self-actualization
Abstrak: Penelitian ini bertujuan untuk mendeskripsikan kepribadian dan aktualisasi diri Unyil dalam animasi Petualangan Si Unyil. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Peneliti dalam penelitian ini berusaha mendeskripsikan kepribadian dan aktualisasi diri Unyil dalam Petualangan Si Unyil. Kepribadian Unyil dianalisis menggunakan teori psikoanalisis Sigmund Freud. Teori psikoanalisis Sigmund Freud, yaitu id, ego, dan superego. Teori hierarki kebutuhan Abraham Maslow digunakan untuk menganalisis pemenuhan aktualisasi diri Unyil. Teori hierarki kebutuhan Abraham Maslow terdiri dari kebutuhan fisiologis, kebutuhan akan keamanan, kebutuhan sosial, kebutuhan harga diri, dan aktualisasi diri. Teknik pengumpulan data yang digunakan yaitu menggunakan metode menonton, mentranskripsi, dan mencatat. Kemudian data-data dalam penelitian ini dikaitkan dengan teori psikoanalisis Sigmund Freud dan hierarki kebutuhan Abraham Maslow. Teori hierarki kebutuhan Abraham Maslow Hasil penelitian ini adalah Unyil memiliki kepribadian yang baik dengan mau menolong orang, berkelakuan baik sesuai norma-norma, kompetitif, dan tidak mementingkan dirinya sendiri. Namun, di waktu tertentu Unyil terkadang egois dan mengejek temannya. Unyil dapat memenuhi sebagian besar kebutuhannya sehingga dapat memenuhi aktualisasi dirinya. Kebutuhan yang tidak dapat dipenuhi Unyil tidak semua karena faktor kesalahannya.
Kata kunci: Unyil, kepribadian, aktualisasi diri
Teaching, technology, and the modern classroom
Authors: Walters Tim , Lydiatt Steve 
Published: June 2021

One of Zayed University’s publicly articulated missions is to lead higher education in the United Arab Emirates through teaching, learning, research, and outreach and to achieve this leadership in a technologically advanced environment. In fulfilling this goal, the university actively promotes laptop computer use among faculty, staff, and students; delivery (and completion) of lessons though advanced technology; use of sophisticated software; and information gathering via the Internet. (See Moore, Moore, Bodwen, Coasdale, 2003.)
Though the hope is that information technology can add a powerful punch to the modern educational environment, many educators in the United Arab Emirates have found that it is the proper use of available modern technology rather than the presence of that technology that advances learning. Even longtime favorites pencil and paper and the overhead projector still have a place in the well-rounded modern classroom. Whether old or new, each technology has unique qualities (or “affordances”) of which advantage can be taken.
Emerging Threats to Human Rights
Authors: Soderstrom Kelly 
Published: June 2021

Emerging Threats to Human Rights: Resources, Violence, and Deprivation of Citizenship, edited by Heather Smith-Cannoy. Philadelphia: Temple University Press, 2019. 288 pages. ISBN-10: 1439917191; ISBN-13: 978-1439917190. RRP: A$93.00, paperback.
Reviewed by Kelly Soderstrom, University of Melbourne, Melbourne, Australia.
Design and optimization of a wideband metasurface for utilization in a highly efficient terahertz reflectarray antenna
Authors: Sharifi Raziyeh , Basiri Raheleh , Zareian-Jahromi Ehsan 
Published: June 2021

Abstract
In this manuscript, two wideband single layer reflectarray antennas are designed utilizing an optimization-based metasurface in terahertz (THz) regime. It is demanded to design a metasurface with wide phase variation range in a broad frequency region of terahertz band. The proposed metasurface is designed based on Random Hill Climbing optimization algorithm whereas a multiobjective fitness function is defined to consider the desired characteristics. A provided link between Matlab and HFSS softwares is utilized to define and simulate various metasurfaces. The finalized cell has considerable wide phase variation (≥ 600˚) and notable bandwidth of 30.76% (1.1–1.5 THz) whereas the mean value of magnitude variation of reflection coefficient is -0.42dB. Two square and circular metasurfaces are designed based on the optimized cell and illuminated using a THz feeding horn antenna. The angles of incident and reflected waves are considered equal to zero. The simulation results confirm 3-dB gain bandwidths of 20.3% and 20.4% for square and circular reflectors, respectively. Moreover, the considerable efficiencies of 45.67% and 46.27% are achieved for square and circular arrays, consequently. The maximum gain of square array with 361 elements is 25.9dB whereas it is equal to 24.9dB for circular metasurface including 277 unit cells.
Viability And Effectiveness of Mindfulness State Measurement Methodology Using Internet of Things: Proof of Concept
Authors: Chiovato André Godoi , Demarzo Marcelo , Notargiacomo Pollyana 
Published: June 2021

Abstract
Purpose: This proof-of-concept study aimed to develop and evaluate the feasibility and preliminary efficiency of a methodology to measure the mindfulness state using a wearable device (“Cap”) capable of monitoring students’ levels of full attention by means of real-time measured heart rate variability (HRV). Methods: The device was developed to export the data to the user’s cell phone via Bluetooth, which in turn stores the securely accessible data in the cloud. The autonomous wearable device consists of electronic boards of the Arduino platform that, in addition to the HRV, detect the heartbeat, the external temperature of the skull surface, and head/neck movements. Results: Preliminary statistical data using rMSSD (root mean squared successive differences), the Poincare map, the Toronto Mindfulness Scale, the Mindful Attention Awareness Scale (MAAS) and the Philadelphia Mindfulness Scale (PMS) show that increased HRV values converge to high values for the mindfulness state when the time difference between R and RN+1 sample is greater than 88 ms. Conclusion: The device proved to be viable and potentially effective for measuring the state of mindfulness. Thus, further studies should be conducted to test it on a large scale as well as in real classroom situations.
Mental Health Burden of Patients With Diabetes Before And After The Outbreak of COVID-19: Predictors of Mental Health Impairment
Authors: Moradian Sheila , Teufel Martin , Jahre Lisa , Musche Venja , Fink Madeleine , Kohler Hannah , Schweda Adam , Weismüller Benjamin , Dörrie Nora , Tan Susanne , Skoda Eva-Maria , Bäuerle Alexander 
Published: June 2021

Abstract
Background: The COVID-19 pandemic is affecting people’s mental health worldwide. Patients with diabetes are at risk for a severe course when infected with SARS-CoV-2. The present study aims to retrospectively examine mental health changes in patients with diabetes in Germany before and after the COVID-19 outbreak, and to furthermore explore potential predictors of such changes.Methods: Over the course of eight weeks in early summer 2020, 253 individuals diagnosed with diabetes participated in an online cross-sectional study. Participants completed an anonymous survey including demographics, depression (PHQ-2) and generalized anxiety symptoms (GAD-2), distress (DT), and health status (EQ-5D-3L). In addition, all instruments used were adjusted to measure participants’ mental health and health status before the COVID-19 outbreak. Additionally examined factors were COVID-19-related fear, trust in governmental actions to face the pandemic, and the subjective level of information about COVID-19.Results: This study shows a significant increase in prevalence of depression symptoms, generalized anxiety symptoms and distress, as well as significantly decreased health statuses in diabetes patients after the COVID-19 outbreak. Increased depression symptoms, generalized anxiety symptoms and distress were predicted by COVID-19-related fear, whereas trust in governmental actions to face COVID-19 predicted higher depression symptoms.Conclusions: The results indicate a negative impact of the COVID-19 outbreak on mental health and health status in patients with diabetes. In order to improve the efficacy of psychological support strategies for diabetes patients during the pandemic, possible predictors of mental health impairment such as the aforementioned should be examined more thoroughly and addressed more openly.
The Effect of ARHGEF15 Knockout and Forebrain-Specific Human ARHGEF15 Knock-In on Seizure Susceptibility in Mice
Authors: Liu Yi-Dan , Ma Meng-Yu , Wang Yan-Ling , Ding Mei-Juan , Yang Yu , Feng Jing-Hui , Zhang Yan-Ke , Liu Zi-Chao , Hao Yan-Lei , Wu Yi-Li , Kong Qing-Xia 
Published: June 2021

Abstract
Background

The ARHGEF15 gene encodes the Rho guanine nucleotide exchange factor 15. Although multiple evidence indicates that ARHGEF15 may be related to epilepsy, it is not clear what role it plays.
Methods

Subjects were homozygous ARHGEF15 knockout (E5−/−) mice, wild-type (WT) mice, Cre-positive homozygous human ARHGEF15 conditional knock-in (E5CKI/CKI•Cre+) mice which can overexpress human Ephexin5 in the forebrain, and Cre-positive (E5WT/WT•Cre+) mice. Models with epileptic seizures were established by intraperitoneal injection of pentylenetetrazol (PTZ) in 60 mg/kg, and seizures were recorded by video. Then 7 indexes were counted, including “maximum seizure level”, “seizure level classification”, “tonic-clonic seizure or not”, “latency of tonic-clonic seizure”, “number of times of tonic-clonic seizure”, “total duration of tonic-clonic seizure”, and “dead or not”. Western blot was used to detect Ephexin5, RhoA, p-RhoA, ROCK2, and p-ROCK2 in WT mice and E5−/− mice.
Results

Compared with WT mice, E5−/− mice had a shorter “total duration of tonic-clonic seizure”. For levels of RhoA, p-RhoA, ROCK2 and p-ROCK2 in the adult hippocampus, there was no significant difference between WT and E5−/−. The level of Ephexin5 was high in the whole brain tissue of 2-day-old WT mice, and an extremely low expression of Ephexin5 was detected in the brain tissue of E5−/− mice of the same age. There was no significant difference between E5CKI/CKI•Cre + mice and E5WT/WT•Cre + mice in seizures.
Conclusions

ARHGEF15 knockout can decrease the “duration of tonic-clonic seizure” in adult mice with epileptic seizures induced by PTZ. ARHGEF15 knockout did not affect the expression of the RhoA-ROCK2 pathway in the hippocampus of adult mice, which probably attributed to no expression of Ephexin5 in the hippocampus of adult mice. The overexpression of human Ephexin5 in the forebrain has no significant effect on the behavior of epileptic seizures induced by PTZ in adult mice.
Phomopsis Liquidambaris Contributes to the Decease of Ethylene Biosynthesis in Rice under Salt Stress via Inhibiting the Activity of 1-Aminocyclopropane-1-Carboxylate Deaminase
Authors: Siddikee M. A. , Zereen M.I. , Wu Mei , Zhang Wei , Dai Chuan Chao 
Published: June 2021

Abstract
The endophytic fungus Phomopsis liquidambaris is characterized as a plant growth-promoting agent under salt stress, but its mechanism is unknown. Herein, 1-Aminocyclopropane-1-Carboxylate Deaminase (ACCD) from the strain was confirmed that it had the ability of utilizing 1-Aminocyclopropane-1-Carboxylate as the sole nitrogen source. The full-length ACCD gene was 1,152 bp, which encodes a mature protein of 384 amino acids with a molecular mass of 41.53 kDa. The ACCD activity was 3.9-fold in 3 mmol L− 1 ACC by qRT-PCR under salt stress comparing with no salt tress. Ethylene production was increased to 34.55–70.60% and reduced the growth of rice by 23–69.73% under salt stress. Inoculation of P. liquidambaris increased root-shoot length, fresh and dry weight, and overall growth of stressed rice seedlings. ACC accumulation, ACC synthase and ACC oxidase activities increased in salt-treated rice seedlings, while they were significantly reduced when P. liquidambaris was inoculated into Rice by qRT-PCR. It therefore can be concluded that P. liquidambaris can be used as a plant growth promoting fungus against salt stress and other biotic or abiotic stresses.
Reflection on the utilization of microplastics as experiment material in laboratory
Authors: Chai Yanchao 
Published: June 2021

Abstract
More and more researches about microplastics (MPs) have been emerging, as the environmental MPs are detected ubiquitously. Various kinds of MPs have been added heavily as exogenous pollution in toxicological experiments. This perspective is intended to figure out utilization situation of MPs in laboratory and discrepancies between the choice of experiment material and environmental composition of MPs. Here we show, the total number of MPs utilized in 204 articles could be equivalent to that contained in 1015 kg dry wastewater treatment sludge, or comparable to the total existing mass in 600 km− 2 South Pacific subtropical gyre. This means that laboratory could be becoming a potential hotspot of MPs pollution as there is no criterion aiming at treatment of MPs-rich experiment waste. In addition, commercial Polystyrene (PS) microsphere with size less 1 µm was one popular experiment material, which is inconsistent with predominant composition of environmental MPs. That probably overestimate the adverse outcome of MPs as these purchased plastic sphere lack representativeness for actual environmental MPs. This work would shed light on the control and calibration of choice of MPs material in the future research.
Two Different Subcortical Networks of Language System: Morphogram and Phonogram, Through the Analysis of Unique Japanese Characters
Authors: Tamai Sho , Kinoshita Masashi , Nakajima Riho , Okita Hirokazu , Nakada Mitsutoshi 
Published: June 2021

Abstract
Language systems worldwide are based on morphograms or phonograms, and Japanese is a unique language that uses a complicated combination of kanji (morphogram) and kana (phonogram) characters. The white matter networks associated with reading have been investigated previously but remain unclear. In this study, we performed intraoperative language mapping under local anesthesia and postoperative language assessments of 65 consecutive patients who underwent surgical resection for cerebral glioma within the dominant temporal or parietal lobe. The cases showing intraoperative dyslexia elicited by direct electrical stimulation (DES) or postoperative kanji and/or kana dyslexia were extracted. Five patients showed transient kanji or kana dyslexia intraoperatively, and 8 patients showed kanji or kana dyslexia postoperatively. During intraoperative mapping, kanji or kana dyslexia were indeed reproduced by DES. We investigated the maximal overlapping lesions of the resection cavity that were associated with kanji or kana dyslexia, and then determined the subcortical elicited points that evoked kanji or kana dyslexia. These areas were localized near three white matter bundles: the arcuate fascicle, posterior superior longitudinal fascicle, and inferior longitudinal fascicle (ILF). The intraoperative DES distributions for kanji dyslexia were especially associated with the anterior-inferior side of the ILF. On the other hand, the DES point associated with kana dyslexia was localized on the posterior-superior side of the complex of these three tracts. These results suggested the presence of specific non-interfering networks that subserved the reading process for morphograms and phonograms.
Loss of Neuroligin 4X Induces an Intrinsic Innate Immune Response in TNBC
Authors: Yirsaw Alehegne , Omar Muhammad G , Elhussin Isra A , King Dequarius , Henderson Henry J , Sandhey Maninder , White Jason , Samuel Temesgen , Karanam Balusubramanyam , Yates Clayton , Bedi Deepa 
Published: June 2021

Abstract
BackgroundImmune checkpoint blockade therapies, which act on T cell inhibitory receptors, including CTLA-4 and PD-1, induce durable responses across diverse cancers. However, most patients do not respond to these therapies, and initially responsive cancers may relapse. Identifying molecular mechanisms that influence therapeutic responses and resistance is critical to realize the full therapeutic potential of immune checkpoint inhibitors. The presence of immune infiltrates in the tumor microenvironment is associated with positive outcomes in breast cancer, specifically in triple-negative breast cancer (TNBC). The underlying mechanisms driving this response are unclear. We have previously identified Neuroligin 4X (NLGN4X) as a protein expressed in TNBC.MethodsBioinformatic analysis was used for pathway analysis of TCGA TNBC patient dataset. Immunohistochemistry was performed on breast cancer tissue microarray for NLGN4X protein expression. RNA-seq was performed on MDA-MB-231 breast cancer cells for differential gene expression upon gene knockdown. Cytokine array, western blot, cell adhesion array and Nanostring was performed to determine the role of NLGN4X in TNBC.ResultsIn this study, we report that NLGN4X expression is lost in breast cancer with lymph node metastasis. Its expression negatively correlates with immune markers in vitro, The Cancer Genome Atlas (TCGA) TNBC patient dataset, and metastatic breast cancer tissues. RNA-seq analysis of the MDA-MB-231 breast cancer cell line, silenced for NLGN4X by siRNA showed more than 500 differentially regulated genes. GSEA analysis of these genes revealed upregulation of interferon signaling pathway, cytokine signaling, and downregulation of cholesterol metabolism and lipid metabolism pathways. NLGN4X knockdown induced loss of cell adhesion, epithelial to mesenchymal transition (EMT), and MAVS-IRF7 signaling in breast cancer cells. Interestingly, analysis of the TCGA dataset of 104 TNBC patients also showed interferon signaling (IFN) as one of the significant pathways downregulated in TNBC patients expressing NLGN4X.ConclusionLoss of NLGN4X leads to innate immune activation in breast cancer and coincides with an aggressive phenotype of cancer. This study identifies the role of NLGN4X in regulating interferon signaling and immune microenvironment in TNBC.
Interaction with Pediatric Healthcare Providers Prior to Admission for Pediatric Critical Illness Due to Respiratory Failure
Authors: Pfarr Marie A , Odetola Fola O , Yagiela Lauren M 
Published: June 2021

Abstract
Objective: To describe pre-hospital healthcare provider contact and the impact of a child’s medical complexity on patterns of contact in the 7 days prior to admission for pediatric critical illness due to respiratory failure.Study Design: Retrospective analysis of data on patients ≤18 years with respiratory failure admitted to a quaternary pediatric intensive care unit between January 1, 2013 and December 31, 2014. Pre-hospitalization provider contact was compared to the child’s medical complexity using Chi square and Kruskal-Wallis tests for categorical and continuous data, respectively.Results: Of 163 patients, the median age was 2.1 years, 59.5% were male, and 33.1% had medical complexity. In the 7 days prior to hospitalization, 68 families (41.7%) had 71 encounters with providers including primary care provider telephone call/office visit (66.2%), telephone contact/office visit with a specialist provider (31%), or urgent care visit (2.8%). Children without medical complexity were more likely than children with medical complexity to have a primary care provider telephone call/ office visit (36.7% vs 13.0%, p=0.004). In contrast, children with medical complexity were more likely to have a telephone call or office visit with a specialist (29.6% vs 5.5%, p<0.001).Conclusions: In the 7 days before hospitalization for pediatric respiratory failure, nearly 1 in 2 families contacted a healthcare provider with illness-related concerns. During acute medical crisis, children without medical complexity were more likely to contact their primary care provider, while children with medical complexity were more likely to contact a specialist. These findings have important implications for pediatric care delivery.
Deciphering Biochemical Responses, Metabolome Analysis and Key Genes Controlling Sorghum [Sorghum Bicolor (L.) Moench] Ion Transport in Responses to Salt Stress
Authors: Punia Himani , Tokas Jayanti , Malik Anurag , Satpal  , Kharor Neeraj , Yashveer Shikha 
Published: June 2021

Abstract
Background: Crops usually encounter several abiotic stresses, and salt stress is one of the major constraints affecting plant growth and agricultural productivity globally. Sorghum is not only a valuable source of food but also a potential model for studying and better understanding the salt stress mechanics in the cereals and obtain a better knowledge of their cellular mechanism. Herein, we examined the effects of salt stress on physio-biochemical and molecular responses of sorghum genotypes to determine their tolerance.
Change of the structure and assembly of bacterial and photosynthetic communities by the ecological engineering practices in Dianchi Lake
Authors: Zhang Dayi , Xie Yucheng , Sheng Yizhi , Li Danni , He Feng , Du Jinsong , Jiang Longfei , Luo Chunling , Deng Songqiang , Li Guanghe 
Published: June 2021

Abstract
Background: Cyanobacterial bloom challenges the aquatic ecosystem and ecological restoration is an effective approach for cyanobacterial bloom control, but the change of aquatic community after ecological restoration is still unclear. Dianchi Lake is a eutrophic lake with frequent cyanobacterial blooms in China, and recent ecological restoration projects in Caohai (north part) have a satisfactory performance. In this study, we collected 249 water samples at 23 sites from Dianchi Lake to explore the relationships between water physiochemical variables and aquatic microbial communities.Results: Water physicochemical variables in Waihai (south part) intensively changed along time, whereas those in Caohai did not. Photoautotrophic communities were significantly divergent between Caohai and Waihai. Waihai had a lower diversity of photoautotrophic community, containing higher abundance of Cyanophyceae (89.9%) than Caohai (42.7%). Nutrient level and Cyanophyceae only exhibited strong correlations in Wahai (p<0.05). Redundancy analysis and microbial ecological network suggested that microbial communities in Caohai had a higher stability. Deterministic process dominated the microbial assembly (50-80% for bacteria and >90% for photoautotrophs), and particularly in Caohai.Conclusions: Our results unraveled that the structure and assembly of bacterial and photoautotrophic communities significantly changed after ecological restoration, offering valuable suggestions that photosynthetic diversity should be focused for other ecological restoration projects.