bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression
Authors: Jia Jiaoying , Ouyang Zhu , Wang Ming , Ma Wenjia , Liu Min , Zhang Mingming , Yu Mengqiang 
Published: July 2021

AbstractMicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquitination of ataxia-telangiectasia mutated interactor (ATMIN). miR-361-5p, ATMIN, and UBR5 levels were clinically analyzed in gliomas tissues, which were further validated in gliomas cell lines. Loss/gain-of-function method was applied to determine the roles of miR-361-5p and UBR5 in gliomas, as to cell viability, migration, invasion, colony formation ability, and apoptosis in vitro and tumorigenesis in vivo. The relationship between miR-361-5p and UBR5 was verified and the interaction between UBR5 and ATMIN was explored. It was detected that reduced miR-361-5p and ATMIN and enhanced UBR5 levels showed in gliomas. Elevating miR-361-5p was repressive in gliomas progression. UBR5 was directly targeted by miR-361-5p. UBR5 can ubiquitinate ATMIN. miR-361-5p suppressed gliomas by regulating UBR5-mediated ubiquitination of ATMIN. Downregulating UBR5 impeded gliomas tumor growth in vivo. Upregulating miR-361-5p targets UBR5 to promote ATMIN protein expression, thus to recline the malignant phenotype of gliomas cells.
The acrocentric part of der(Y)t(Y;acro)(q12;p1?2) contains D15Z1 sequences in the majority of cases
Authors: Fuchs Sigrid , Lisfeld Jasmin , Kankel Stefanie , Person Luisa , Liehr Thomas 
Published: July 2021

AbstractChromosomal heteromorphisms (CHMs) are currently largely disregarded in human genetic diagnostics. One exception is der(Y)t(Y;acro)(q12;p1?2), which has at least been mentioned in karyotypes and discussed in reports. This derivative is frequently observed in healthy males with idiopathic infertility, which is not uncommon for CHMs. Here, we present the first systematic fluorescence in situ hybridization (FISH)-based study of 7 carriers of der(Y)t(Y;acro)(q12;p1?2). Specific probes for 15p11.2 (D15Z1) and 22p11.2 (D22Z4) were applied to answer the question of whether either of the short arms may be involved in the formation of the derivative Y-chromosome. In 6 out of 7 cases, specific staining was achieved using the D15Z1 probe, while the derivative acrocentric chromosomal region was not positive for D22Z4 in any of the 7 cases.In conclusion, this study implies that the acrocentric chromosomal region is derived from chromosome 15 in the majority of cases with der(Y)t(Y;acro)(q12;p1?2).
Multiple evolutionary lineages for the main vector of Leishmania guyanensis, Lutzomyia umbratilis (Diptera: Psychodidae), in the Brazilian Amazon
Authors: Scarpassa Vera Margarete , Cunha-Machado Antônio Saulo , Alencar Ronildo Baiatone 
Published: July 2021

AbstractLutzomyia umbratilis is the main vector of Leishmania guyanensis in the Brazilian Amazon and in neighboring countries. Previous biological and molecular investigations have revealed significant differences between L. umbratilis populations from the central Brazilian Amazon region. Here, a phylogeographic survey of L. umbratilis populations collected from nine localities in the Brazilian Amazon was conducted using two mitochondrial genes. Statistical analyses focused on population genetics, phylogenetic relationships and species delimitations. COI genetic diversity was very high, whereas Cytb diversity was moderate. COI genealogical haplotypes, population structure and phylogenetic analyses identified a deep genetic differentiation and three main genetic groups. Cytb showed a shallower genetic structure, two main haplogroups and poorly resolved phylogenetic trees. These findings, allied to absence of isolation by distance, support the hypothesis that the Amazon and Negro Rivers and interfluves are the main evolutionary forces driving L. umbratilis diversification. The main three genetic groups observed represent three evolutionary lineages, possibly species. The first lineage occurs north of the Amazon River and east of Negro River, where Le. guyanensis transmission is intense, implying that L. umbratilis is an important vector there. The second lineage is in the interfluve between north of Amazon River and west of Negro River, an area reported to be free of Le. guyanensis transmission. The third lineage, first recorded in this study, is in the interfluve between south of Amazon River and west of Madeira River, and its involvement in the transmission of this parasite remains to be elucidated.
Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
Authors: Olesiński Tomasz , Lutkowska Anna , Balcerek Adam , Sowińska Anna , Piotrowski P , Trzeciak Tomasz , Maj Tomasz , Hevelke Piotr , Jagodziński Pawel P. 
Published: July 2021

AbstractThe role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n = 214) and controls (n = 502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (ptrend = 0.028), a strong risk of the GC genotype in male (ptrend = 0.035) but not female (ptrend = 0.747) patients, and the association with non-cardia GC (ptrend = 0.041), tumour stages T3 (ptrend = 0.014) and T4 (ptrend = 0.032), differentiation grading G3 (ptrend = 0.009), lymph node metastasis stage N3 (ptrend = 0.0005) and metastasis stage M0 (ptrend = 0.027). We found that significantly increased BMI1 transcripts were associated with the primary GC genotype classified as grade G3 (p = 0.011) and as lymph node metastasis N3 (p = 0.010) and counterpart marginal tissues (p = 0.026, p = 0.040, respectively) from carriers of the T/T versus C/C genotypes. rs67085638 may contribute to increased BMI1 transcripts and the progression and rapid growth of GC.
The unbalanced reorganization of weaker functional connections induces the altered brain network topology in schizophrenia
Authors: Mastrandrea Rossana , Piras Fabrizio , Gabrielli Andrea , Banaj Nerisa , Caldarelli Guido , Spalletta Gianfranco , Gili Tommaso 
Published: July 2021

AbstractNetwork neuroscience shed some light on the functional and structural modifications occurring to the brain associated with the phenomenology of schizophrenia. In particular, resting-state functional networks have helped our understanding of the illness by highlighting the global and local alterations within the cerebral organization. We investigated the robustness of the brain functional architecture in 44 medicated schizophrenic patients and 40 healthy comparators through an advanced network analysis of resting-state functional magnetic resonance imaging data. The networks in patients showed more resistance to disconnection than in healthy controls, with an evident discrepancy between the two groups in the node degree distribution computed along a percolation process. Despite a substantial similarity of the basal functional organization between the two groups, the expected hierarchy of healthy brains' modular organization is crumbled in schizophrenia, showing a peculiar arrangement of the functional connections, characterized by several topologically equivalent backbones. Thus, the manifold nature of the functional organization’s basal scheme, together with its altered hierarchical modularity, may be crucial in the pathogenesis of schizophrenia. This result fits the disconnection hypothesis that describes schizophrenia as a brain disorder characterized by an abnormal functional integration among brain regions.
Newtonalized orthogonal matching pursuit for the linear frequency‐modulated pulse frequency agile radar
Authors: Zhu Jiang , Guo Honghui , Zhang Ning , Song Chunyi , Xu Zhiwei 
Published: July 2021

AbstractThe linear frequency‐modulated frequency agile radar (FAR) can be used for synthesizing high‐range‐resolution profiles (HRRP), and also has excellent electronic counter‐countermeasures performance. Similar to the Newtonalized orthogonal matching pursuit (NOMP) for line spectral estimation problem, the NOMP for the FAR radar termed as NOMP‐FAR is designed to process each coarse range bin to extract the HRRP and velocities of multiple targets, including the guide for determining the oversampling factor and the stopping criterion. In addition, it is shown that the target will cause false alarm in the nearby coarse range bins, and a post‐processing algorithm is proposed to suppress the ghost targets. Numerical simulations are conducted to demonstrate the effectiveness of NOMP‐FAR.
Radio study of HESS J1857+026: Gamma-rays from a superbubble?
Authors: Petriella A. , Duvidovich L. , Giacani E. 
Published: July 2021

Aims. We provide new insights into the nature of HESS J1857+026, a very-high-energy γ-ray source whose complex morphology in the TeV band was attributed to the superposition of two distinct sources.
Methods. We performed radio continuum observations to look for the pulsar wind nebula and the supernova remnant associated with the pulsar PSR J1856+0245, which might be powering part of the γ-ray emission. We observed HESS J1857+026 with the Karl G. Jansky Very Large Array (VLA) at 1.5 GHz in the C configuration. In addition, using the same array configuration, we observed a region of 0.4° × 0.4° towards PSR J1856+0245 at 6.0 GHz. We obtained complementary data for the neutral hydrogen and molecular gas emission from public surveys in order to investigate the properties of the interstellar medium in the direction of HESS J1857+026.
Results. The new observations at 1.5 GHz do not show evidence of emission above the noise level of 0.7 mJy beam−1 that could be associated with either HESS J1857+026 or PSR J1856+0245. Also, in the new image at 6.0 GHz we do not detect radio emission from a pulsar wind nebula powered by PSR J1856+0245. The neutral gas analysis shows the existence of a superbubble in the direction of the γ-ray source. We suggest that this structure is located at ~5.5 kpc, compatible with the distance to the pulsar PSR J1856+0245.
Conclusions. We conclude that TeV emission from HESS J1857+026 originates in a superbubble, arguing in favour of a single γ-ray source rather than the superposition of two distinct sources. The pulsar PSR J1856+0245 could also be contributing as a source of γ-rays within the bubble.
Pyloruserhaltende partielle Pankreatoduodenektomie mit segmentaler Pfortaderresektion
Authors: Brunner Maximilian , Krautz Christian , Maak Matthias , Weber Georg F. , Grützmann Robert 
Published: July 2021

Zusammenfassung
Einleitung Die pyloruserhaltende partielle Pankreatoduodenektomie stellt eine komplexe viszeralchirurgische Operation dar, insbesondere, wenn simultan eine Resektion und
Rekonstruktion der portalvenösen Achse notwendig wird. Eine entscheidende Rolle im Rahmen der Operation spielt die Versorgung des verbleibenden Restpankreas, da die postoperative
Pankreasfistel (POPF) eine häufige Komplikation mit relevanten Folgen für die betroffenen Patienten darstellt. Für die Anastomosierung des Restpankreas stehen verschiedene Techniken zur
Verfügung: die am häufigsten angewendeten sind die Gang-zu-Mukosa-Pankreatikojejunostomie, die invaginierende Pankreatojejunostomie, die Blumgart-Anastomose sowie die
Pankreatogastrostomie.
Indikation Histologisch gesichertes Adenokarzinom des Pankreaskopfes.
Prozedur Offene pyloruserhaltende partielle Pankreatoduodenektomie mit segmentaler Pfortaderresektion.
Schlussfolgerung Ein standardisiertes und strukturiertes Vorgehen bei der pyloruserhaltenden partiellen Pankreatoduodenektomie hilft, diesen komplexen Eingriff sicher durchzuführen.
Die Durchführung einer simultanen Pfortaderresektion erhöht zwar die Komplexität des Eingriffes – nichtsdestotrotz sollte aber bei Verdacht auf Infiltration der portalvenösen Achse die
Indikation zur En-bloc-Resektion großzügig gestellt werden, da intraoperativ nicht sicher zwischen einer entzündlichen Adhärenz und einer Tumorinfiltration differenziert werden kann und eine
Pfortader-/V.-mesenterica-superior-Resektion die Morbidität und Mortalität des Eingriffes nicht wesentlich erhöht. Das Ziel ist immer eine R0-Resektion. Die Wahl der operativen Technik zur
Versorgung des Restpankreas sollte vom Operateur anhand von dessen Expertise und ggf. an den vorliegenden Situs adaptiert getroffen werden, da nach aktueller Evidenzlage die wichtigsten
Anastomosetechniken hinsichtlich der POPF-Rate gleichwertig erscheinen.
Effect of Irrigating Agitation after Root End Preparation on the Wall Cleaning and Bond Strength of Calcium Silicate Material in Retrograde Obturation
Authors: Valencia Yahir Muñoz , Vertuan Gislene Cristina , Alcalde Murilo Priori , Vivan Rodrigo Ricci , Reis Só Marcus Vinícius , Duarte Marco Antonio Hungaro 
Published: July 2021

Abstract
Objective This study aimed to evaluate the cleaning efficacy of irrigant activation with a new ultrasonic tip in root-end preparations and to determine its influence on the bond strength of calcium silicate-based material.
Materials and Methods Maxillary canines were prepared and filled, and their root ends resected. Root-end cavities were ultrasonically prepared and randomly distributed into four groups according to the final irrigation protocols: G1 (ultrasonic irrigation [UI] + saline solution [SS]), G2 (syringe irrigation [SI] + SS), G3 (UI + ethylenediaminetetraacetic acid [EDTA]), and G4 (SI + EDTA). Cleaning efficacy analysis employed 72 specimens (n = 18) split longitudinally for imaging of the same areas by scanning electron microscopy (SEM). The percentage of dentinal tubules opened before and after irrigation was used as evaluation parameter. Push-out testing employed 40 specimens (n = 10) sectioned apical region perpendicularly, which slice was placed on a testing machine for the bond strength measurement and failure mode was assessed by SEM. The data were statistically analyzed (α ≤ 0.05).
Results G3 (UI + EDTA) removed the smear layer more effectively, showed the best tubule opening (p < 0.05), and presented the highest mean bond strength values (p < 0.05). Failure modes were predominantly adhesive, except for the G3 (UI + EDTA) group, in which they were mainly mixed (80%).
Conclusion The results of this study suggest that EDTA 17% agitation promoted better cleaning and smear layer removal, improving the push-out bond strength of calcium silicate material in retrograde obturation.
Influence of Smoking Habits on the Prevalence of Dental Caries: A Register-Based Cohort Study
Authors: de Araújo Nobre Miguel A. , Sezinando Ana M. , Fernandes Inês C. , Araújo Andreia C. 
Published: July 2021

Abstract
Objective This study aimed to evaluate the influence of smoking habit on the prevalence of dental caries lesions in a follow-up study.
Materials and Methods A total of 3,675 patients (2,186 females and 1,489 males) with an average age of 51.4 years were included. Outcome measures were the incidence of dental caries defined as incipient noncavitated, microcavitated, or cavitated lesions which had been diagnosed through clinical observation with mouth mirror and probe examination evaluating change of texture, translucency, and color; radiographic examination through bitewing radiographs; or secondary caries through placement of a new restoration during the follow-up of the study.
Statistical Analysis Cumulative survival (time elapsed with absence of dental caries) was estimated through the Kaplan–Meier product limit estimator with comparison of survival curves (log-rank test). A multivariable Cox proportional hazards regression model was used to evaluate the effect of smoking on the incidence of dental caries lesions when controlled to age, gender, systemic status, frequency of dental hygiene appointments, and socioeconomic status. The significance level was set at 5%.
Results Eight hundred sixty-three patients developed caries (23.5% incidence rate). The cumulative survival estimation was 81.8% and 48% survival rate for nonsmokers and smokers, respectively (p < 0.001), with an average of 13.5 months between the healthy and diseased state diagnosis. Smokers registered a hazard ratio for dental caries lesions of 1.32 (p = 0.001) when controlled for the other variables of interest.
Conclusion Within the limitations of this study, it was concluded that smoking habit might be a predictor for dental caries.
Association between Interleukin-1β Gene Polymorphism and Chronic Periodontitis
Authors: Majeed Muhammad Mansoor , Ahmed Imtiaz , Roome Talat , Fatima Tehseen , Amin Rafat 
Published: July 2021

AbstractObjectives Periodontitis is a pathological condition of the oral cavity, originating from multiple factors, including microbial, environmental and genetic factors. The vulnerability to several pathologies has been studied with the relationship to genetic polymorphisms, and one of the most prominent is the single nucleotide polymorphisms throughout the genome. The study aimed to find out the association of single nucleotide polymorphism (SNP) of interleukin-1β +3954 gene with chronic periodontitis (CP) in PakistanMaterials and Methods This case–control study was conducted at Dow University of Health Sciences. DNA was extracted from the blood and amplified by using conventional polymerase chain reaction of respective genes followed by sequencing. Mann–Whitney test accessed the difference of clinical parameters between cases and controls, and Fisher’s exact test was applied to access the association of alleles between subjects. Data entered and analyzed using SPSS 21.Results Significant differences were observed in clinical parameters in cases and controls (p < 0.001). In the IL-1β +3954 gene, T alleles were significantly higher in cases as compared with controls (p < 0.001). Genotype CC was significantly dominant in the controls and genotype CT and TT in patients (Chi-square = 19.83, p < 0.001).Conclusion Within the study’s limits, IL-1β +3954 gene polymorphism is associated with periodontitis and is expected to be among the several causes of respective pathology in Pakistan’s population.
Fibrolipomatous Hamartoma Arising from the Median Nerve—A Case Report
Authors: Pallewatte Aruna S. , Samarasinghe Eshma C. 
Published: July 2021

AbstractFibrolipomatous hamartoma is a rare nonhereditary, congenital condition characterized by benign hyperplasia of fibroadipose tissue around nerve bundles. The median nerve is commonly affected. Underlying pathological process is mature adipose and fibrous tissue infiltrating the epineural and perineural compartments giving typical “pseudo-onion bulb” appearance on histology and “coaxial cable” appearance on magnetic resonance imaging (MRI). This case of fibrolipomatous hamartoma well illustrates its characteristic clinical, radiological, and histopathological features. Patient is a teenage female presented with painless gradually enlarging mobile lump in the central left palm. Ultrasound scan revealed a hyperechoic subcutaneous lesion, with intervening fine hypoechoic cable like structures following the course of median nerve which was thickened. Computed tomography (CT) confirmed thickened left median nerve with radiating isodense fascicles surrounded by fatty areas. There were no calcifications. MRI showed classic “coaxial cable” like T1, T2 isointense fascicles continuous with the median nerve surrounded by a fusiform lesion demonstrating fat signals on spin-echo sequences which dropped on fat-suppressed gradient echo sequences. Diagnosis of fibrolipomatous hamartoma arising from left median nerve was made, based on typical imaging findings. Biopsy confirmed fibrolipomatous hamartoma. Diagnosis can be made confidently on imaging alone especially with MRI, without the need of biopsy. Both CT and MRI demonstrate fatty mass encasing the thickened nerve fibers. On MRI, characteristic appearance is seen as T1 and T2 low intense tubular thickened neural bundles surrounded by high signal fatty tissue.
An eye-tracking study of phonological awareness in Emirati
Arabic
Authors: Marquis Alexandra , Kaabi Meera Al , Leung Tommi , Boush Fatima 
Published: July 2021

Abstract
This paper studies phonological awareness in
Emirati Arabic by tracking eye movements. Thirty-eight Arabic
participants, divided into feedback and no feedback groups, were
evaluated on three phonological conditions: (1) explicit
instructions for onset consonant matching, (2)
implicit instructions for segmentation of initial
consonant, and (3) rhyme matching. We
hypothesized that (1) fixations would differ according to the
phonological conditions, (2) subjects would perform better on explicit instructions compared to implicit instructions, (3) subjects would perform better in the two consonant conditions compared to the rhyme
condition, and (4) feedback would improve performance. The experiment
shows that accuracy on the consonant conditions was higher than in
the rhyme condition. Fixation patterns differed between the
consonant conditions and the rhyme condition, and this effect was
dependent on the administration of feedback, suggesting that eye
tracking can be used to evaluate phonological awareness in Emirati
Arabic.
The relationship between word and nonword repetition and
receptive and expressive vocabulary skills in Gulf Arabic speaking
children
Authors: Khater Mariam 
Published: July 2021

Abstract
This study investigates early phonological
skills, as represented by nonword repetition (NWR), in typically
developing (TD) Gulf Arabic speaking children and children with
language impairment, and tries to examine findings in relation to
two important NWR hypotheses: the phonological short term memory
account (PSTM, Gathercole &
Baddeley, 1990a) and the linguistic account of Snowling, Chiat, and Hulme
(1991). We developed a new Arabic word and nonword
repetition test (WNRep) and tested 44 TD children and a clinical
group (CL) of 15 children with language impairment, between two and
four years old. Scores were measured using the percent phonemes
correct (PPC) and whole word correct (WWC) methods. The results show
that the TD group scored significantly higher than the CL group on
the WNRep and across one, two and three-syllable words/nonwords, and
that NWR scores correlated significantly with receptive and
expressive vocabulary tests. Apart from its ability to differentiate
between TD and children with language impairment, NWR results
revealed significant differences in groups’ performance even on
one-syllable word and nonwords, which differs from findings in other
languages. The two different scoring methods did not make any
significant contribution to the groups’ results.
Can’t Wait Any Longer? The Effects of Shorter Waiting Periods on Divorce and Remarriage
Authors: Crystal Wong Ho-Po 
Published: July 2021

Abstract
Since the 1990s, many U.S. states have enacted or lengthened the waiting periods required for parties to divorce with the goal of strengthening marriage or at least discouraging divorce. I use the length of time by which some states have shortened their waiting periods to analyze how such waiting periods affect remarriage rates. I find that when the waiting period is shortened to 1.5 years or less, remarriage rates decrease for relatively young people but increase for older people. To the extent that remarriage is pivotal for older women impoverished by divorce to recover economically and emotionally, my results suggest that—though longer waiting periods might preserve some marriages—a prolonged period might reduce the welfare of older divorced women by hampering their remarriage prospects.