bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a derived version of the IPF-specific Saint George’s Respiratory Questionnaire
Authors: Prior Thomas Skovhus , Hoyer Nils , Shaker Saher Burhan , Davidsen Jesper Rømhild , Hilberg Ole , Patel Haridarshan , Bendstrup Elisabeth 
Published: October 2021

Abstract
Background
Health-related quality of life (HRQL) is impaired in patients with idiopathic pulmonary fibrosis (IPF). HRQL is often measured using the St. George’s Respiratory Questionnaire (SGRQ) despite the development of an IPF-specific version (SGRQ-I). Using data from a real-world cohort of patients with IPF, we aimed to transform SGRQ into a derived version of SGRQ-I, SGRQ-Ider, to examine the cross-sectional and longitudinal validity of SGRQ-Ider and to compare SGRQ-Ider to SGRQ-I.

Methods
Based on results from SGRQ, SGRQ-Ider was derived applying the algorithm used to develop SGRQ-I. Of the 50 items in SGRQ, 34 items were retained in SGRQ-Ider. Response options for seven items were collapsed and minor adjustments were made to the weights of two items after correspondence with the developers of SGRQ-I. Cross-sectional validation, responsiveness and minimal clinically important difference (MCID) were assessed by comparison to other HRQL instruments, pulmonary function tests and 6-min walk test performed at baseline, 6 and 12 months. Furthermore, the association between SGRQ-Ider scores and mortality was examined.

Results
A total of 150 IPF patients participated and 124 completed follow-up at 12 months. SGRQ-Ider performed comparably to SGRQ-I with a high concurrent validity, good test–retest reliability and high known-groups validity. SGRQ-Ider was responsive to change in HRQL and physiological anchors. MCID of SGRQ-Ider for improvement and deterioration was 3.5 and 5.7, respectively. SGRQ-Ider scores were associated with mortality in both univariate (HR 1.82, 95% CI 1.42–2.34 per 20-point increase) and multivariate analyses (HR 1.57, 95% CI 1.20–2.05 per 20-point increase).

Conclusions
The SGRQ-Ider is a valid, reliable and responsive HRQL instrument in patients with IPF and has psychometric properties comparable to SGRQ-I. Thus, SGRQ results can reliably be transformed into the SGRQ-Ider. The MCID estimates were calculated for improvement and deterioration separately. Increasing SGRQ-Ider score was associated with increased mortality.
Renal cell carcinoma with unusual metachronous metastasis up to 22 years after nephrectomy: two case reports
Authors: Bruckschen F. , Gerharz C. D. , Sagir A. 
Published: October 2021

Abstract
Introduction
Renal cell carcinoma is the third most common malignant tumor in the urogenital tract. An estimated 25% of renal cell carcinomas are in stage IV when diagnosed. The 5-year-survival with stage IV is about 20%. Late metastases are found after an extended disease-free interval up to 20 years after primary nephrectomy.

Case presentation
Here, we present two cases with late-onset metastasis of renal cell carcinoma with different clinical presentations. The first patient, an 88-year-old Caucasian man, presented with bleeding of the upper gastrointestinal tract. Biopsies taken from the duodenal bulb showed a tumor compatible with a solitary metastasis from renal cell carcinoma 22 years ago. The second patient, a 79-year-old Caucasian man, consulted our gastroenterological department with results of an outpatient computed tomography scan with multiple suspected tumor areas in the liver, omentum, thyroid, and mediastinum. A computed tomography-guided liver biopsy was performed that showed a clear-cell tumor consistent with a metastasis of the renal cell carcinoma 17 years ago.

Conclusion
Both cases show that patients with a history of renal cell carcinoma should be followed up for a longer time than patients with other malignant tumors.
EFL teachers’ perceptions and practices of their language assessment knowledge
Authors: Farhady Hossein , Tavassoli Kobra 
Published: October 2021

AbstractResearch on language assessment knowledge (LAK) of teachers has focused on two major topics: identifying the LAK needs of teachers and developing appropriate LAK tests. Although the prior research findings significantly contributed to our understanding of the parameters of LAK, they were mostly quantitative and did not provide much information about EFL teachers’ perceptions and applications of their LAK in a direct and face-to-face situation. Therefore, this qualitative study was designed to shed light on some key issues related to teachers’ LAK using semi-structured interviews. The issues included EFL teachers’ perception of their LAK and their utilization of LAK in their teaching. The participants were 11 teachers with a high level of LAK and 10 teachers with a low level of LAK determined by their performance on a LAK test. The interviews were recorded, transcribed, and content analyzed. The findings did not reveal significant differences in the responses provided by the two groups of teachers. Further, to investigate the extent of teachers’ application of LAK in classroom contexts, some of the tests made by the participating teachers were collected and content analyzed. The results showed that teachers with high LAK wrote longer tests with more varied sections and tasks. Finally, no meaningful relationship was found between the teachers’ level of LAK and their students’ performance on classroom achievement tests. The findings imply that the language assessment field needs more research on multiple dimensions of LAK.
Comparative analysis of information tendency and application features for projection mapping technologies at cultural heritage sites
Authors: Li Hengyi , Ito Hiromu 
Published: October 2021

Abstract
With the rapid development of interactive technologies using projection mapping (PJM), these digital technologies have introduced new interpretative possibilities for the presentation of cultural heritage sites. PJM attracts more visitors with greater expectations to cultural heritage sites through its excellent visual effects and guidance capabilities. In the past decade, especially after 2015, design events have frequently introduced digital projections to cultural heritage sightseeing spots worldwide. However, this trend has also led to the emergence of many digital projection events that merely exhibit beautiful projection effects on buildings and neglect to show the history and value of the cultural heritage site. Based on this phenomenon, this study compiled and analyzed 45 related cases of PJM applications at cultural heritage sites around the world from the past 5 years. These 45 examples were studied by disassembling the projection content, analyzing the information characteristics exhibited in each projection video, and arranging the obtained data on a timeline chart for analysis. According to the data, two information characteristics of PJM at cultural heritage sites can be observed: “the relationship between projection content and heritage” and “information tendency.” The advantages and limitations of these characteristics were distinguished and suggestions for the application of PJM on cultural heritage sites were derived. These results can be used as a reference for other research studies on visitors to cultural heritage sites and improving digital interpretation and presentation designs.
Current perspective on production and applications of microbial cellulases: a review
Authors: Bhardwaj Nisha , Kumar Bikash , Agrawal Komal , Verma Pradeep 
Published: October 2021

AbstractThe potential of cellulolytic enzymes has been widely studied and explored for bioconversion processes and plays a key role in various industrial applications. Cellulase, a key enzyme for cellulose-rich waste feedstock-based biorefinery, has increasing demand in various industries, e.g., paper and pulp, juice clarification, etc. Also, there has been constant progress in developing new strategies to enhance its production, such as the application of waste feedstock as the substrate for the production of individual or enzyme cocktails, process parameters control, and genetic manipulations for enzyme production with enhanced yield, efficiency, and specificity. Further, an insight into immobilization techniques has also been presented for improved reusability of cellulase, a critical factor that controls the cost of the enzyme at an industrial scale. In addition, the review also gives an insight into the status of the significant application of cellulase in the industrial sector, with its techno-economic analysis for future applications. The present review gives a complete overview of current perspectives on the production of microbial cellulases as a promising tool to develop a sustainable and greener concept for industrial applications.
Application of near-infrared spectroscopy technology in the complex fermentation system to achieve high-efficiency production
Authors: Yang Chen , Lingli Chen , Meijin Guo , Xu Li , jinsong Liu , Xiaofeng Liu , Zhongbing Chen , Xiaojun Tian , Haoyue Zheng , Xiwei Tian , Ju Chu , Yingping Zhuang 
Published: October 2021

AbstractThe fermentation process is dynamically changing, and the metabolic status can be grasped through real-time monitoring of environmental parameters. In this study, a real-time and on-line monitoring experiment platform for substrates and products detection was developed based on non-contact type near-infrared (NIR) spectroscopy technology. The prediction models for monitoring the fermentation process of lactic acid, sophorolipids (SLs) and sodium gluconate (SG) were established based on partial least-squares regression and internal cross-validation methods. Through fermentation verification, the accuracy and precision of the NIR model for the complex fermentation environments, different rheological properties (uniform system and multi-phase inhomogeneous system) and different parameter types (substrate, product and nutrients) have good applicability, and R2 was greater than 0.98, exhibiting a good linear relationship. The root mean square error of prediction shows that the model has high credibility. Through the control of appropriate glucose concentration in SG fermentation as well as glucose and oil concentrations SLs fermentation by NIR model, the titers of SG and SLs were increased to 11.8% and 26.8%, respectively. Although high cost of NIR spectrometer is a key issue for its wide application in an industrial scale. This work provides a basis for the application of NIR spectroscopy in complex fermentation systems.
Adults have more male-biased sex ratios than first-winter juveniles in wintering duck populations
Authors: Wood Kevin A. , Brides Kane , Durham Maurice E. , Hearn Richard D. 
Published: October 2021

Abstract
Background
The long-term monitoring of demographic changes in waterbird populations remains limited, but such information can be valuable for conservationists and waterbird managers. Biased sex ratios can indicate differences in survival rates between sexes. In particular, differences in the sex ratios of fledged juveniles and adults can provide insight into the development of male bias among populations.

Methods
In this study, we used data from individual birds captured over a 57-year period to assess the extent, and temporal variability in male bias in nine populations of ducks wintering in the United Kingdom: Gadwall (Mareca strepera), Northern Mallard (Anas platyrhynchos), Northern Pintail (Anas acuta), Common Pochard (Aythya ferina), Common Shelduck (Tadorna tadorna), Northern Shoveler (Spatula clypeata), Eurasian Teal (Anas crecca), Tufted Duck (Aythya fuligula), and Eurasian Wigeon (Mareca penelope).

Results
Overall, eight of these populations were significantly male-biased and adults were more male-biased than first-winter juveniles for all nine populations. The increased male bias among adults is consistent with the hypothesis that factors such as higher mortality of reproductive-age females during the breeding season is a major cause of male bias in duck populations. However, such predation cannot explain the male bias detected in first-winter juveniles in four of the populations. The temporal trends in male bias differed between adults and first-winter juveniles in Northern Mallard, Northern Pintail, Common Pochard, Common Shelduck, Eurasian Teal, Tufted Duck, and Eurasian Wigeon. Over the study period we found increased male bias among adult Northern Mallard, Northern Pintail, Common Pochard, Common Shelduck, and Tufted Duck as well as both adult and first-winter juvenile Northern Shoveler.

Conclusions
We provide evidence that among wintering duck populations, sex ratios are typically male-biased, with adults exhibiting stronger male-biased sex ratios than first-winter juveniles. Improved monitoring of sex ratios of wintering waterbirds would help to increase our understanding of changes in waterbird demography, population structure, and observed population trends; our study shows that birds caught during ringing projects can be a valuable source of such data.
EEG-based human emotion recognition using entropy as a feature extraction measure
Authors: Patel Pragati , R Raghunandan , Annavarapu Ramesh Naidu 
Published: October 2021

AbstractMany studies on brain–computer interface (BCI) have sought to understand the emotional state of the user to provide a reliable link between humans and machines. Advanced neuroimaging methods like electroencephalography (EEG) have enabled us to replicate and understand a wide range of human emotions more precisely. This physiological signal, i.e., EEG-based method is in stark comparison to traditional non-physiological signal-based methods and has been shown to perform better. EEG closely measures the electrical activities of the brain (a nonlinear system) and hence entropy proves to be an efficient feature in extracting meaningful information from raw brain waves. This review aims to give a brief summary of various entropy-based methods used for emotion classification hence providing insights into EEG-based emotion recognition. This study also reviews the current and future trends and discusses how emotion identification using entropy as a measure to extract features, can accomplish enhanced identification when using EEG signal.
Equity and inclusivity in research: co-creation of a digital platform with representatives of marginalized populations to enhance the involvement in research of people with limited literacy skills
Authors: Loignon Christine , Dupéré Sophie , Leblanc Caroline , Truchon Karoline , Bouchard Amélie , Arsenault Johanne , Pinheiro Carvalho Julia , Boudreault-Fournier Alexandrine , Marcotte Sylvain Aimé 
Published: October 2021

AbstractTo improve health equity, as well as equity in research, community-engaged research and participatory research needs to be inclusive. Equity in health research refers to the principle that anyone affected by research or who can benefit from its outcomes should have equal opportunities to contribute to it. Many researchers advocate the importance of promoting equity in research and engage in processes that foster the research involvement of lay persons, patients, and community members who are otherwise “absent” or “silent”. Still, people with limited literacy skills who experience unwarranted structural barriers to healthcare access have little involvement in research. Low literacy is a major barrier to equity in health research. Yet there exist approaches and methods that promote the engagement in research of people with literacy challenges. Building on our previous research projects conducted with community members using participatory visual and sound methods (participatory mapping, photovoice, digital storytelling, etc.), we embarked on the co-creation of a digital platform in 2017. Our aim in this commentary is to report on this co-creation experience that was based on a social justice-oriented partnership. The development of the online platform was overseen by a steering committee made up of workers from community organizations involved with people with limited literacy skills, students, and researchers. In the development process, the co-creation steps included a literature review, informal interviews with key informants, and discussion and writing sessions about format and content. After numerous challenges raised and addressed during co-creation, the Engage digital platform for engagement in research went live in the winter of 2020. This platform presents, on an equal footing, approaches and methods from academic research as well as from the literacy education community engaged with people with limited literacy skills.
Treatment delay from aneurysmal subarachnoid hemorrhage to endovascular treatment: a high-volume hospital experience
Authors: Zhang Xiaoxi , Tang Haishuang , Zuo Qiao , Xue Gaici , Duan Guoli , Xu Yi , Hong Bo , Zhao Rui , Yang Pengfei , Liu Jianmin , Huang Qinghai 
Published: October 2021

Abstract
Background
Early treatment for patients with aneurysmal subarachnoid hemorrhage (aSAH) could significantly reduce the risk of re-bleeding and improve clinical outcomes. We assessed the different time intervals from the initial hemorrhage, admission, and endovascular treatment and identified the risk factors contributing to delay.

Methods
Between February 2017 and December 2019, 422 consecutive aSAH patients treated in a high-volume hospital were collected and reviewed. Risk factors contributing to admission delay and treatment delay were analyzed with univariate and multivariate analysis.

Results
One hundred twenty-two (28.9%) were admitted to the high-volume hospital at the day of symptom onset and 386 (91.5%) were treated with endovascular management at the same day of admission. The multivariate analysis found that younger age (P = 0.022, OR = 0.981, 95% CI 0.964–0.997) and good Fisher score (P = 0.002, OR = 0.420, 95% CI 0.245–0.721) were independent risk factors of admission delay. None was found to be related with treatment delay. Multivariate analysis (OR (95% CI)) showed that higher age 1.027 (1.004–1.050), poorer Fisher score 3.496 (1.993–6.135), larger aneurysmal size 1.112 (1.017–1.216), and shorter interval between onset to admission 1.845 (1.018–3.344) were independent risk factors of poorer clinical outcome.

Conclusion
Treatment delay was mainly caused by pre-hospital delay including delayed admission and delayed transfer. Our experience showed that cerebrovascular team could provide early treatment for aSAH patients. Younger age and good Fisher score were significantly related with admission delay. However, admission delay was further significantly correlated with better clinical outcome.
Beauveria bassiana: as a potential microbial biocontrol agent for tea mosquito bug, Helopeltis theivora Waterhouse (Hemiptera: Miridae) in Dooars and Darjeeling, India
Authors: Deka Bhabesh , Babu Azariah , Peter Arulmarianathan John , Pandey Abhay Kumar , Kumhar Kishor Chand , Sarkar Suman , Rajbongshi Hirakjyoti , Dey Pritam , Amalraj Emmanuel Leo Daniel , Talluri Venkateswara Rao 
Published: October 2021

AbstractBackgroundIn the present study, the efficacy of two isolates ofBeauveria bassiananamely, BKN20 and BKN1/14 was evaluated against the tea mosquito bug (TMB),Helopeltis theivora,Waterhouse (Hemiptera: Miridae) damaging harvestable shoots of tea plants in the Dooars and Darjeeling regions of West Bengal, India.ResultsLaboratory study revealed that, in both isolates, BKN20 was more pathogenic than BKN1/14, exhibiting 76% mortality of the test insect. The BKN20 isolate was formulated as an aqueous suspension (5%AS), and evaluated against TMB through micro-plot trials in tea plantations. The Micro-plot field study revealed a maximum of 72.19% reduction in the shoot damage due to TMB in plots sprayed with a 1000 ml/ha concentration of BKN20 5%AS containing 2 × 107conidia/ml, as compared to the synthetic insecticide (Thiamethoxam 25%WG), where a 63.12% reduction in the shoots was recorded. Furthermore, different concentrations of the formulated BKN20 5%AS were evaluated against the test insect at 2 locations of tea gardens in the Dooars and Darjeeling regions. The results from both locations revealed that 1000 and 1200 ml/ha concentrations of BKN20 5%AS (each concentration containing 2 × 107conidia/ml) significantly (p < 0.05) reduced the TMB population and they were more effective than Thiamethoxam 25%WG (120 g/ha). However, non-significant differences in crop yields were recorded. The formulation BKN20 5%AS was found to be non-pathogenic to non-target insects, i.e. natural enemies present in the tea ecosystem. BKN20 5%AS had no phytotoxic effect on the tea leaves, with acceptable organoleptic attributes.ConclusionThe BKN20 isolate could be commercialized as an alternative microbial insecticide to reduce the load of chemical insecticides in the tea ecosystem.
Early administration of gonadotropin-releasing hormone antagonist versus flexible antagonist ovarian stimulation protocol in poor responders: a randomized clinical trial
Authors: Esfidani Tayebeh , Moini Ashraf , Arabipoor Arezoo , Mojtahedi Maryam Farid , Mohiti Shima , Salehi Ensieh , Kashani Ladan 
Published: October 2021

Abstract
Background
Determining the initiation day of antagonist administration is an important and challenging issue and different results have been reported in the previous studies. The present study was designed to compare the controlled ovarian hyperstimulation (COH) cycles outcomes of early-onset gonadotropin-releasing hormone antagonist (GnRH-ant) protocol with conventional flexible GnRH-ant protocol in patients with poor ovarian response (POR) diagnosis. This randomized clinical trial was performed on infertile women who were diagnosed as poor responders in in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) cycles at Arash Women’s Hospital affiliated to Tehran University of Medical Sciences. POR was defined according to the Bologna criteria and the eligible women were randomly allocated into an experimental (early-onset GnRH-ant) and control (conventional flexible GnRH-ant) groups. The women in the experimental group received recombinant gonadotropins (150–225 IU) and GnRH-ant (0.25 mg) simultaneously on the second day of the cycle. In the control group, the starting and the dose of gonadotropins were similar but daily administration of GnRH-ant was initiated when the leading follicle diameter was ≥ 13 mm. The COH outcomes were compared between groups (n=58 in each group).

Results
The analysis showed that the two groups did not have statistically significant differences in terms of the ovarian stimulation duration and the total dose of used gonadotropins. The total number of metaphase II (MII) oocytes in the experimental group was significantly higher than that of in control group (P = 0.04). Moreover, clinical and ongoing pregnancy rates per embryo transfer (ET) in the experimental group were significantly higher than those in the control group (P = 0.02 and P = 0.03, respectively); however, the implantation and miscarriage rates were similar between groups.

Conclusions
The early-onset GnRH-ant protocol can improve the number of retrieved and MII oocytes and probably the pregnancy outcomes after fresh embryo transfer in POR patients. However, larger randomized clinical trials are required to compare the pregnancy outcomes after this approach with other COH protocols with considering cost-effectiveness issue.

Trial registration
IRCT20110731007165N9.
The name of the registry: Ladan Kashani.
The date of trial registration: 8.02.2020.