bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Design of an Evaluation Framework for Diabetes Self-Management Education and Support Programs Delivered Nationally
Authors: Olson Jenny Louise , White Becky , Mitchell Helen , Halliday Jennifer , Skinner Timothy , Schofield Deborah , Sweeting Jennifer , Watson Natasha 
Published: March 2021

Abstract
Background
The aim of this work was to develop a National Evaluation Framework to facilitate the standardization of delivery, quality, reporting, and evaluation of diabetes education and support programs delivered throughout Australia through the National Diabetes Services Scheme (NDSS). The NDSS is funded by the Australian Government, and provides access to diabetes information, education, support, and subsidized product across diverse settings in each state and territory of Australia through seven independent service-providers. This article reports the approach undertaken to develop the Framework.
Methods
A participatory approach was undertaken, focused on adopting nationally consistent outcomes and indicators, nominating objectives and measurement tools, specifying evaluation processes, and developing quality standards. Existing programs were classified based on related, overarching indicators enabling the adoption of a tiered system of evaluation.
Results
Two outcomes (i.e., improved clinical, reduced cost) and four indicators (i.e., improved knowledge and understanding, self-management, self-determination, psychosocial adjustment) were adopted from the Eigenmann and Colagiuri national consensus position statement for diabetes education. This allowed for the identification of objectives (i.e., improved empowerment, reduced distress, autonomy supportive program delivery, consumer satisfaction) and related measurement instruments. Programs were categorized as comprehensive, topic-specific, or basic education, with comprehensive programs allocated to receive the highest-level of evaluation. Twelve quality standards were developed, with existing programs tested against those standards. Based on the results of testing, two comprehensive (OzDAFNE for people with type 1 diabetes, DESMOND for people with type 2 diabetes), and eight topic-specific (CarbSmart, ShopSmart, MonitorSmart, FootSmart, MedSmart, Living with Insulin, Insulin Pump Workshop, Ready Set Go – Let’s Move) structured diabetes self-management education and support programs were nominated for national delivery.
Conclusions
The National Evaluation Framework has facilitated consistency of program quality, delivery, and evaluation of programs delivered by multiple service providers across diverse contexts. The Framework could be applied by other service providers who facilitate multiple diabetes education and support programs and could be adapted for use in other chronic disease populations where education and support are indicated.
Body Appreciation Scale (BAS-2): Measurement Invariance across Genders and Item Response Theory Examination.
Authors: Zarate Daniel , Marmara Joshua , Potoczny Camilla , Hosking Warwick , Stavropoulos Vasielios 
Published: March 2021

Abstract
Background: The present study considers a measure of positive body image, the Body Appreciation Scale-2, which assesses acceptance and/or favourable opinions towards the body (BAS-2[29]). Differential functioning of the scale across the two genders, as well as its items, has not been excluded. The present study contributes to this area of knowledge via the employment of gender Measurement Invariance (MI) and Item Response Theory (IRT) analyses. Methods: A group of 386 adults from the community were assessed (N = 394, 54.8% men, 43.1% women, M age = 27.48; SD = 5.57). Results: MI analysis observed invariance across males and females at the configural level, and non-invariance at the metric level. Further, the two-parameter logistic model employed to observe IRT properties indicated that all items demonstrated, although variable, strong discrimination capacity. Conclusions: The items showed increased reliability for latent levels of ∓ 2 SD from the mean level of Body Appreciation. The implications and interpretations of the findings for clinical practice are discussed.
Ginkgolide B derivative synthesis and their effects on the viability of SKOV3 cells
Authors: Feng Zi-Li , Zhu Zhi-Bin , Chen Wang , Xu Jia-Yuan , Bai Yu , Hu Dai-Hua , Zhao Zheng-Dong 
Published: March 2021

Abstract
The natural product GB was used as a raw material and modified by esterification on C10-OH or C1-OH to obtain 11 derivatives (1 to 11), which were structurally characterized with nuclear magnetic resonance spectroscopy. An MTT assay-based in vitro tumor proliferation inhibitory activity test showed that compounds 2, 3, 6, 7, 10, and 11 exhibited strong inhibitory activity against the human ovarian cancer cells SKOV3, with IC50 values of 16.05 µmol/L, 15.65 µmol/L, 32.00 µmol/L, 63.30 µmol/L, 23.20 µmol/L, and 31.10 µmol/L, respectively. Annexin V/PI double staining assay showed that compound 2 induced apoptosis in SKOV3 cells to a slightly greater extent than GB and compounds 5, and 9, with an apoptosis rate of 31.68%.
Effect and Associated Factors of a Clinical Pharmacy Model in the Incidence of Medication Errors in the Hospital Pablo Tobón Uribe Eacpharmodel Study: Stepped Wedge Randomized Controlled Trial (NCT03338725).
Authors: Granados Johan , Amariles Pedro , Botero-Aguirre Juan Pablo , Ortiz-Cano Natalia Andrea , Valencia-Quintero Andrés-Felipe , Salazar-Ospina Andrea 
Published: March 2021

Abstract
BackgroundThe World Health Organization considers medication errors to be an issue that requires attention at all levels of care, to reduce the severe and preventable harm related to drug therapy. In the world, clinical pharmacy practice standards have been proposed, where the pharmacist, as part of the multidisciplinary health team, can help improve patient safety; however, more and better evidence needs to demonstrate this effect. ObjectiveTo assess the change in the incidence of medication errors in hospitalized patients and thereby identify drug-related factors and problemsSettingThe study was conducted at Hospital Pablo Tobón Uribe, medellín, Colombia.MethodsA randomized, controlled cluster-wedge staggered trial with a duration of 14 months was conducted to compare the clinical pharmacy practice model's effect with the usual care process in the hospital. Five hospital health care units were included, which were initially assigned to the control group, and after an observation period of 2 months, they were randomly assigned to the intervention group.Main outcome measureIncidence of medication errors in hospitalized patientsResultsThe medication error incidence was 13.3% and 22.8% for the intervention group and control group, respectively. The probability of presenting medication error was 48% lower when the patient was in the intervention group (RR 0.52; 95% CI:0.34-0.79).ConclusionThe Clinical pharmacy practice model of the Hospital Pablo Tobón Uribe Hospital, made up of strategies focused on reducing medication errors, significantly reduces medication errors in patients during hospitalization compared to usual practice.
Risk factors for unplanned removal of central venous catheters in hospitalized children with hematological and oncological disorders
Authors: Miyagishima Moe , Hamada Motoharu , Hirayama Yuji , Muramatsu Hideki , Tainaka Takahisa , Shirota Chiyoe , Hinoki Akinari , Imaizumi Takahiro , Nakatochi Masahiro , Kamei Michi , Nishikawa Eri , Kawashima Nozomu , Narita Atsushi , Nishio Nobuhiro , Kojima Seiji , Takahashi Yoshiyuki 
Published: March 2021

Abstract
ObjectiveCentral venous catheters (CVCs) have been essential devices for the treatment of children with hematological and oncological disorders. Only few studies investigated the complications and selections of different types of CVCs in these pediatric patients. This study aimed to compare risk factors for unplanned removal of two commonly used CVCs, i.e., peripherally inserted central catheters (PICCs) and tunneled CVCs, and propose better device selection for the patient.MethodsThis retrospective, single center cohort analysis was conducted on pediatric patients with hematological and oncological disorders inserted with either a PICC or a tunneled CVC.ResultsBetween January 1, 2013, and December 31, 2015, 89 patients inserted with tunneled CVCs (total 21,395 catheter-days) and 84 with PICCs (total 9,177 catheter-days) were followed up until the catheter removal. The median duration of catheterization was 88 days in PICCs and 186 days in tunneled CVCs (p = 1.24×10-9). PICCs at the 3-month cumulative incidence of catheter occlusion (5.2% vs. 0%, p = 4.08×10-3) and total unplanned removal (29.0% vs 7.0%, p = 0.0316) were significantly higher, whereas no significant difference was observed in the cumulative incidence of central line-associated bloodstream infection (11.8% vs. 2.3%, p = 0.664). Multivariable analysis identified younger age (<2 years) (subdistribution hazard ratio [SHR], 2.29; 95% confidence interval [CI], 1.27–4.14) and PICCs (SHR, 2.73; 95% CI, 1.48–5.02) were independent risk factors for unplanned removal.ConclusionOur results suggest that tunnel CVCs would be a preferred device for children with hematological and oncological disorders requiring long-term, intensive treatment.
Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151
Authors: Lee Bohm , Lee Jinyoung , Jeon Yewon , Kim Hyemin , Kwon Minjae , Shin Jung Eun , Cho Yongcheol 
Published: March 2021

Abstract
Gene expression profiling in response to nerve injury has been mainly focused on protein functions of coding genes to understand mechanisms of axon regeneration and to identify targets of potential therapeutics for nerve repair. However, the protein functions of several highly injury-induced genes including Gpr151 for regulating the regenerative ability remain unclear. Here we present an alternative approach focused on non-coding functions of the coding genes, which led to the identification of the Gpr151 RNA function as a molecular sponge via its interaction with RNA-binding proteins such as CSDE1. Gpr151 promotes axon regeneration by the function of its 5’- untranslated region (5’UTR) and expression of an engineered form of the 5’UTR improves regenerative capacity in vitro and in vivo in both sciatic nerve and optic nerve injury models. Our data suggest that searching injury-induced coding genes potentially functioning by their non-coding regions is required for the RNA-based gene therapy for improving axon regeneration.
Sevoflurane Post-Conditioning Alleviated Hypoxic-Ischemic Brain Injury in Neonatal Rats by Inhibiting Endoplasmic Reticulum Stress-Mediated Autophagy via IRE1 Signalings
Authors: Niu Jiayuan , Wu Ziyi , Xue Hang , Zhang Yahan , Gao Qiushi , Li Chang , Zhao Ping 
Published: March 2021

Abstract
Post-conditioning with sevoflurane, a volatile anesthetic, has been proved to be neuroprotective against hypoxic-ischemic brain injury (HIBI). Our previous research showed that autophagy is over-activated in a rat model of neonatal HIBI, and inhibition of autophagy confers neuroprotection. There is increasing recognition that autophagy can be triggered by activating endoplasmic reticulum (ER) stress. This study aimed to explore: i) the relationship between ER stress and autophagy in the setting of neonatal HIBI; and ii) the possible roles of ER stress-mediated autophagy and IRE1 signalings in the neuroprotection of sevoflurane post-conditioning against neonatal HIBI. Seven-day-old rats underwent left common artery ligation followed by 2 h hypoxia (8% O2 / 92% N2). The relationship between ER stress and autophagy was examined by ER stress inducer (tunicamycin), ER stress inhibitor (4-PBA), or autophagy inhibitor (3-MA). Rats in the sevoflurane post-conditioning groups were treated with 2.4% sevoflurane for 30 min after HIBI induction. The roles of ER stress-mediated autophagy and the IRE1/JNK/beclin1 signaling pathway in the neuroprotection afforded by sevoflurane were examined by ER stress inducer (tunicamycin) and the IRE1 inhibitor (STF-083010). HIBI over‑activated ER stress and autophagy in neonatal rats. HIBI-induced autophagy was significantly aggravated by tunicamycin but blocked by 4-PBA; however, HIBI-induced ER stress was not affected by 3-MA. Sevoflurane post-conditioning significantly alleviated ER stress, autophagy, cell apoptosis, and cognitive impairments, which were remarkably abolished by tunicamycin. Also, tunicamycin blocked sevoflurane-induced downregulation of IRE1/JNK/beclin1 signaling pathway. Whereas, IRE1 inhibitor could reverse the effects of tunicamycin. ER stress contributes to autophagy induced by HIBI. Furthermore, sevoflurane post-conditioning significantly protects against HIBI in neonatal rats by inhibiting ER stress-mediated autophagy via IRE1/JNK/beclin1 signaling pathway.
Scalable High-Speed Hybrid Complementary Integrated Circuits based on Solution-Processed Organic and Inorganic Transistors
Authors: Wei Xiaozhu , Kumagai Shohei , Makita Tatsuyuki , Tsuzuku Kotaro , Yamamura Akifumi , Sasaki Mari , Watanabe Shun , Takeya Jun 
Published: March 2021

Abstract
Printed electronics offer a cost-efficient way to realise flexible electronic devices. The combined use of p-type and n-type semiconductors would yield silicon-like integrated circuits with low power consumption and stability. However, printing complementary circuits is challenging due to a lack of suitable material systems. To counter this, we employed a hybrid system to integrate p-type organic semiconductors (OSCs) and n-type amorphous metal oxide semiconductors (MOSs). These damage-free patterned OSC- and MOS-based thin-film transistors with improved process durability allowed the fabrication of hybrid complementary circuits on flexible substrates. These inverters functioned well even after exposure to air for 5 months. A large noise margin and power gain of 38 were realised with a supply voltage as low as 7 V. Furthermore, a five-stage ring oscillator with a stage propagation delay of 1.3 µs was achieved, which is the fastest operation ever reported for printed, flexible complementary inverters.
Machine learning model to predict mental health crisis from electronic health records
Authors: Garriga Roger , Matić Aleksandar , Mas Javier , Abraha Semhar , Nolan Jon , Harrison Oliver , Tadros George 
Published: March 2021

Abstract
Timely identification of patients who are at risk of mental health crises opens the door for improving the outcomes and for mitigating the burden and costs to the healthcare systems. Due to high prevalence of mental health problems, a manual review of complex patient records to make proactive care decisions is an unsustainable endeavour. We developed a machine learning model that uses Electronic Health Records to continuously identify patients at risk to experience a mental health crisis within the next 28 days. The model achieves an area under the receiver operating characteristic curve of 0.797 and an area under the precision-recall curve of 0.159, predicting crises with a sensitivity of 58% at a specificity of 85%. The usefulness of our model was tested in clinical practice in a 6-month prospective study, where the predictions were considered clinically useful in 64% of cases. This study is the first one to continuously predict the risk of a wide range of mental health crises and to evaluate the usefulness of such predictions in clinical settings.
FastGLLVM: Big Data Ordination Towards Intensive Care Event Count Cases
Authors: Caraka Rezzy Eko , Chen Rung Ching , Lee Youngjo , HUANG SU-WEN , CHIOU SHYUE-YOW , Pardamean Bens 
Published: March 2021

Abstract
Background: In the heart data mining and machine learning, dimension reduction is needed to remove the multicollinearity. Meanwhile, it has been proven to improves the interpretation of the parameter model. In addition, dimension reduction is also can increase the time of computing in high dimensional data. Methods: In this paper, we perform high dimensional ordination towards event counts in intensive care hospital , following emergency department (ED 1), First Intensive Care Unit (ICU1), Second Intensive Care Unit (ICU2), Respiratory Care Intensive Care Unit (RICU), Surgical Intensive Care Unit (SICU), Subacute Respiratory Care Unit (RCC), Trauma and Neurosurgery Intensive Care Unit (TNCU), Neonatal Intensive Care Unit (NICU) which use the Generalized Linear Latent Variable Models (GLLVM’s). Results: During the analysis, we measure the performance and calculate the time computing of GLLVM with employing variational approximation and Laplace approximation, and compare the different distributions including Negative Binomial, Poisson, Gaussian, ZIP, and Tweedi, respectively. Conclusions: In a nutshell, GLLVM’s leads as best performance reaching the accuracy 98% comparing other methods. In line with this, we get the best model negative binomial and Variational approximation which provides the best accuracy by accruacy value of AIC, AICc, and BIC. In a nutshell, our best model is GLLVM-VA Negative Binomial with AIC 7144.07 and GLLVM-LA Negative Binomial with AIC 6955.922.
Improving Antibacterial and Anti-biofilmic properties of urological catheters with Eucalyptus, Rosemary, Green tea and Ziziphora extracts by impregnation method
Authors: Akhlaghi-Ardekani Najme , Mohebbi-Kalhori Davod , samimi Abdolreza , Karazhyan Reza 
Published: March 2021

Abstract
The main complications of urinary catheters are the bacteria's biofilm formation and the urinary tract infection caused by gram-positive and gram-negative bacteria. In the recent years, the attention has changed its direction toward the antimicrobial, anti-biofilmic, and hydrophobicity effects of herbal extracts. Some of these extracts can inhibit the colonization of the two bacteria Staphylococcus aureus and Escherichia coli which are resistant to antibiotics. These bacteria can stick to the surface of polymer materials due to their hydrophobicity. Thus, antibacterial hydrophilic herbal extracts are supposed to help reduce the risk of the surficial infection if they are used to impregnate the urinary catheters. In this research, the extracts of these four plants eucalyptus, rosemary, green tea and ziziphora were used as the antibacterial agents. After the impregnation and modification of the sample catheters, they were tested by AFM, FE-SEM, ATR-FTIR methods to measure their mechanical, chemical, and hydrophilic properties, during the 21-day experiment period, compared to non-impregnated ones. The tests showed the silicone catheters impregnated by the herbal extracts have some significant anti-biofilmic and antibacterial properties (P˂0.0001) due to the increase in their hydrophilic property. The impregnated catheters could be release the extracts and killed bacteria in 21 days Therefore; some herbal extracts can be good alternatives to chemical drugs.
Elevated Serum Levels of Herpes Virus Entry Mediator and IL-5 in Cough Variant Asthma Versus Classic Asthma Patients
Authors: Yao Can , Yang Zhong , Chen Dandan , Fang Wei , Zhang Yu , Li Binbin , Li Sinian , Chen Rongchang , Shi Fei 
Published: March 2021

Abstract
BackgroundCough variant asthma (CVA) is a special phenotype of asthma. The precise inflammatory features of patients with CVA, however, is still unclear. We aimed to elucidate the differential inflammatory features in patients with CVA in contrast to patients with classic asthma (CA). MethodsA total of 68 patients with persistent uncontrolled asthma (34 with CVA, 34 with CA) in Shenzhen People’s Hospital between August 2018 and May 2019 were enrolled. We collected the demographic data, pulmonary function test (PFT) parameters, hematological variables, and several serum biomarkers. Receiver operating characteristic (ROC) curves were generated to evaluate the values of biomarkers for distinguishing between CVA and CA. ResultsCompared with CA group, CVA group had a higher percentage of females (73.5 vs. 50%, P = 0.046), lower proportion of asthma family history (5.9 vs. 29.4%, P = 0.011), shorter disease course [12.0 (4.8, 39) vs. 96.0 (48.0, 240.0) months, P < 0.001], and better pulmonary function (P all < 0.05). Increased levels of blood eosinophil count [0.35 (0.13, 0.94) vs. 0.34 (0.01, 0.53) X109/L, P = 0.045], eosinophil percentage [6.3 (3.0, 9.8) vs. 4.4 (0.2, 8.4) %, P = 0.046], serum IL-5 [104.19 (89.03, 199.66) vs. 84.57 (26.87, 103.58) ng/L, P = 0.011], and serum herpesvirus entry mediator (HVEM) [128.53 (100.89, 204.83) vs. 90.71 (37.05, 108.08) pg/mL, P = 0.002] were also found in CVA patients compared to those in CA patients. The logistic analysis revealed that serum HVEM had a strong predictive power for CVA group (OR = 1.105, P = 0.015). The sensitivities and specificity of serum HVEM and IL-5 to distinguish between CVA and CA at optimal cut-offs were 85.0% and 61.1%; 85.0% and 61.1%, respectively. AUCs of serum HVEM and IL-5 were 0.789 and 0.739, respectively. Furthermore, serum HVEM and IL-5 had no correlation with PFT parameters in CVA group (P all > 0.05).ConclusionsElevated serum levels of HVEM and IL-5 are exhibited in CVA patients, which may indicate their important roles in the pathogenesis and progression of CVA.
MiR-1-3p Downregulation Delays Endochondral Ossification of the Acetabular Roof in DDH
Authors: Ding Rui , liu xijuan , zhang jian , yuan jinghong , zheng sikuan , cheng xigao , Jia Jingyu 
Published: March 2021

Abstract
Background: Developmental dysplasia of the hip (DDH) is a highly prevalent hip disease among children. However, its pathogenesis remains unclear. MiRNAs are important regulators in cartilage development. In previous study, miRNA high-throughput sequencing on an animal model of DDH showed a low level of miR-1-3p in the cartilage of acetabular roof (ARC), but its role in DDH pathogenesis was not addressed. Therefore, our aim was to investigate the effects of miR-1-3p in the ARC.Methods: The X-ray examination was performed to confirm acetabular dysplasia, MRI imaging and HE staining was conducted to further evaluate the ARC thickness in each animal model. The FISH was used to confirm the expression of miR-1-3p in the ARC and chondrocytes. The target gene of miR-1-3p was predicted by bioinformatics database. The dual-luciferase reporter gene assay was used to confirm the targeting relationship between miR-1-3p and SOX9. The gene expression of miR-1-3p, SOX9, RUNX2 and collagen type X by QPCR analysis. The relative proteins level was detected by western blot analysis. The level of SOX9, RUNX2 and collagen type X in the ARC through immunohistochemistry analysis. Alizarin Red S staining was used to observe the mineralized nodules produced by chondrocytes.Results: The low expression of miR-1-3p in the ARC of DDH. SOX9 is miR-1-3p target gene. Downregulation the expression of miR-1-3p in vitro and demonstrated significantly reduced chondrocytes generated mineralized nodules, as opposed to the control. We also confirmed that, with miR-1-3p silencing, SOX9 expression was upregulated, whereas expression of genes associated with endochondral osteogenesis RUNX2 and collagen type X were downregulated. To confirm the involvement of miR-1-3p silencing in abnormal ossification through SOX9, we also performed a rescue experiment where SOX9 silencing restored the low expression of RUNX2 and collagen type X, produced by miR-1-3p downregulation. Lastly, the elevated SOX9 levels and reduced RUNX2 and collagen type X levels in the ARC of DDH rabbits were also verified, using immunohistochemistry, RT-PCR, and western blot. Conclusion: The low expression of mir-1-3p in the ARC of DDH, which may be the cause of the acetabular roof abnormal endochondral ossification in DDH.