bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of the combination of whole body vibration and shoe with an unstable surface in chronic ankle instability treatment: a randomized clinical trial
Authors: Shamseddini Sofla Farideh , Hadadi Mohammad , Rezaei Iman , Azhdari Negar , Sobhani Sobhan 
Published: March 2021

Abstract
Background
Chronic ankle instability (CAI) is a common condition following an ankle sprain. This study investigated the effects of whole body vibration (WBV) and shoe with an unstable surface training on balance, functional performance, strength, joint position sense in people with CAI.

Method
Thirty- four peoples with unilateral CAI were randomly assigned to three groups: WBV group, WBV with shoe with an unstable surface (WBV-S), and no treatment control group (CON). The WBV group received 4 weeks progressive WBV training and the WBV-S group received progressive WBV training with shoe with an unstable surface. Modified star excursion balance test (mSEBT)reach distance, Hop-Test, muscle strength, and joint position sense were measured at baseline and after the 4 weeks; Moreover, the mSEBT and Hop-Test were reassessed again 2 weeks post intervention.

Results
The result showed a significant group-by-time interaction for anterior and posterolateral directions of mSEBT. The reach distance of these directions at post-intervention and follow-up increased significantly compare to pre-intervention in the WBV and WBV-S groups but not significantly change in the CON group. The Hop test in the WBV-S group was significantly more at post-intervention and follow-up compared to pre-intervention. However, no significant changes were observed in WBV and CON groups. No significant changes were observed for mSEBT posteromedial direction, muscles strength, and joint position sense errors.

Conclusion
The 4 weeks WBV and WBV-S interventions could improve balance in peoples with CAI. Improvement in Hop test was only observed in the WBV-S group suggesting the added value of combining WBV and shoe with an unstable surface as an effective therapy compared to WBV training alone. The use of WBV and WBV-S were not associated with significant changes in strength and joint position sense variables over a four-week period.

Trial registration
This work registered in the Iranian Registry of Clinical Trials (IRCT20151118025105N4).
Self-care practice and its predictors among adults with diabetes mellitus on follow up at public hospitals of Arsi zone, southeast Ethiopia
Authors: Kassa Rahel Nega , Ibrahim Ibrahim Yimer , Hailemariam Hana Abera , Habte Mekdes Hailegebriel 
Published: March 2021

Abstract
Objective
Diabetes mellitus is a chronic illness that requires ongoing patient self-management and support to prevent acute complications and to reduce the risk of long- term complications. The objective of the study was to assess diabetic self-care practice and its predictors among adults with diabetes mellitus on follow up at hospitals of Arsi zone, southeast Ethiopia.

Results
Above half (53.3%) of diabetic patients had good self-care practice. Younger age (AOR: 8.95, 95% CI 1.89,42.48), earning a high income (AOR: 2.495, 95% CI 1.0,5.85), having a family history of diabetes (AOR: 4.5, 95% CI 1.3, 15.5), long duration since the diagnosis of diabetes (AOR: 2.14,95% CI 1.127,4.05), not having diabetic complications (AOR: 3.87, 95% CI 2, 7.48), and having glucometer (AOR: 4.08, 95% CI 1.78 l, 9.33) were significantly associated factors with good diabetic self care practice. Efforts should be made to prevent complications of diabetes mellitus, to support patients who are aged and who have no glucometer at their home to promote good self-care practice. Particularly, health care providers should give special attention to newly diagnosed patients.
Global and Latin American female participation in evidence-based software engineering: a systematic mapping study
Authors: Felizardo Katia Romero , Ramos Amanda Möhring , O. Melo Claudia de , de Souza Érica Ferreira , Vijaykumar Nandamudi L. , Nakagawa Elisa Yumi 
Published: March 2021

Abstract
Context
While the digital economy requires a new generation of technology for scientists and practitioners, the software engineering (SE) field faces a gender crisis. SE research is a global enterprise that requires the participation of both genders for the advancement of science and evidence-based practice. However, women across the world tend to be significantly underrepresented in such research, receiving less funding and less participation, frequently, than men as authors in research publications. Data about this phenomenon is still sparse and incomplete; particularly in evidence-based software engineering (EBSE), there are no studies that analyze the participation of women in this research area.

Objective
The objective of this work is to present the results of a systematic mapping study (SM) conducted to collect and evaluate evidence on female researchers who have contributed to the area of EBSE.

Method
Our SM was performed by manually searching studies in the major conferences and journals of EBSE. We identified 981 studies and 183 were authored/co-authored by women and, therefore, included.

Results
Contributions from women in secondary studies have globally increased over the years, but it is still concentrated in European countries. Additionally, collaboration among research groups is still fragile, based on a few women as a bridge. Latin American researchers contribute a great deal to the field, despite they do not collaborate as much within their region.

Conclusions
The findings from this study are expected to be aggregated to the existing knowledge with respect to women’s contribution to the EBSE area. We expect that our results bring up a reflection on the gender issue and motivate actions and policies to attract female researchers to this area.
Steroid-refractory dermatologic and pulmonary toxicity in a patient on rituximab treated with pembrolizumab for progressive urothelial carcinoma: a case report
Authors: Hines Jacobi , Daily Ellen , Pham Anh Khoa , Shea Christopher R. , Nadeem Urooba , Husain Aliya N. , Stadler Walter M. , Reid Pankti 
Published: March 2021

Abstract
Background
Increasingly widespread use of programmed cell death protein 1 (PD-1) immune checkpoint inhibitors (ICIs) for treatment of a variety of progressive malignancies continues to reveal a range of immune-related adverse events (irAEs), necessitating immunosuppressive therapy for management. While a single course of systemic corticosteroids may be sufficient for many irAEs, no clear standard-of-care guidelines exist for steroid-refractory cases. We present an unusual case of a patient who developed several steroid-refractory novel irAEs on pembrolizumab despite ongoing B cell-directed immunosuppressive therapy with rituximab, who ultimately noted resolution of symptoms with tacrolimus, a T-cell-directed immunosuppressant.

Case presentation
This 72-year-old Caucasian man with Waldenstrom’s macroglobulinemia and myelin-associated glycoprotein (MAG) immunoglobulin M (IgM) antibody-associated neuropathy was being treated with maintenance rituximab and intravenous immunoglobulin when he was started on pembrolizumab (2.26 mg/kg) for metastatic urothelial cancer 31 months after surgery and adjuvant chemotherapy. After his third dose of pembrolizumab, he developed a painful blistering papular rash of the distal extremities. He received two more doses of pembrolizumab before he also developed diarrhea, and it was held; he was initiated on 1 mg/kg prednisone for presumed ICI-induced dermatitis and colitis. Skin biopsy 10 weeks after cessation of pembrolizumab and taper of steroids to 20 mg daily revealed a unique bullous erythema multiforme. He was then admitted with dyspnea and imaging concerning for necrotizing pneumonia, but did not respond to antibiotic therapy. Bronchoscopy and biopsy revealed acute fibrinous organizing pneumonia. His symptoms failed to fully respond to multiple courses of high-dose systemic corticosteroids and a trial of azathioprine, but pneumonia, diarrhea, and skin rash all improved markedly with tacrolimus. The patient has since completed his therapy for tacrolimus, continues off of ICI, and has not experienced a recurrence of any irAEs, though has more recently experienced progression of his cancer.

Conclusion
Despite immunosuppression with rituximab and intravenous immunoglobulin, two immunomodulators targeting B cells, ICI cessation, and systemic corticosteroid therapy, our patient developed two high-grade unusual irAEs, bullous erythema multiforme and acute fibrinous organizing pneumonia. Our patient’s improvement with tacrolimus can offer critical insight into the pathophysiology of steroid-refractory irAEs.
Severe acute respiratory syndrome coronavirus-2- or pregnancy-related cardiomyopathy, a differential to be considered in the current pandemic: a case report
Authors: Nejadrahim Rahim , Khademolhosseini Sara , Kavandi Hadiseh , Hajizadeh Reza 
Published: March 2021

Abstract
Background
There are limited data on cardiovascular complications of coronavirus disease 2019 in pregnancy, and there are only a few case reports on coronavirus disease 2019 related cardiomyopathy in pregnancy. Differentiation between postpartum cardiomyopathy and coronavirus disease 2019 related cardiomyopathy in pregnant women who develop severe acute respiratory syndrome coronavirus-2 infection during peripartum could be challenging. Here, we present a case of possible coronavirus disease 2019 related cardiomyopathy in a pregnant patient, followed by a discussion of potential differential diagnosis.

Case presentation
In this case report, we present the case of a young pregnant Iranian woman who developed heart failure with pulmonary edema after cesarean section. She was treated because of low left ventricular ejection fraction and impression of postpartum cardiomyopathy, and her severe dyspnea improved by intravenous furosemide. On day 3, she exhibited no orthopnea or leg edema, but she was complaining of severe and dry cough. Further evaluation showed severe acute respiratory syndrome coronavirus-2 infection.

Conclusions
The possibility of severe acute respiratory syndrome coronavirus-2 infection should be considered in any pregnant woman who develops cardiomyopathy and pulmonary edema.
Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6
Authors: Yang Chih-Yu , Chang Pu-Yuan , Chen Jun-Yi , Wu Bo-Sheng , Yang An-Hang , Lee Oscar Kuang-Sheng 
Published: March 2021

Abstract
Background
Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells (ADSCs) on peritoneal fibrosis. However, the role of the peritoneal macrophage in this process remains uninvestigated.

Methods
We examined the therapeutic effects of ADSC and bone marrow-derived mesenchymal stem cells (BM-MSC) in the rat model of dialysis-induced peritoneal fibrosis using methylglyoxal. In addition, treatment of macrophages with the conditioned medium of ADSC and BM-MSC was performed individually to identify the beneficial component of the stem cell secretome.

Results
In the in vivo experiments, we found dialysis-induced rat peritoneal fibrosis was attenuated by both ADSC and BM-MSC. Interestingly, ADSC possessed a more prominent therapeutic effect than BM-MSC in ameliorating peritoneal membrane thickening while also upregulating epithelial cell markers in rat peritoneal tissues. The therapeutic effects of ADSC were positively associated with M2 macrophage polarization. In the in vitro experiments, we confirmed that interleukin-6 (IL-6) secreted by MSCs upon transforming growth factor-β1 stimulation promotes M2 macrophage polarization.

Conclusions
In dialysis-induced peritoneal fibrosis, MSCs are situated in an inflammatory environment of TGF-β1 and secrete IL-6 to polarize macrophages into the M2 phenotype. Our findings reveal a previously unidentified role of tissue macrophage in this antifibrotic process. ADSC has the advantage of abundance and accessibility, making the application values extremely promising.

Graphical abstract
In dialysis-induced peritoneal fibrosis, peritoneal mesothelial cells secrete transforming growth factor-β1 (TGF-β1) when exposed to methylglyoxal (MGO)-containing peritoneal dialysate. When situated in TGF-β1, the inflammatory environment induces mesenchymal stem cells to secrete interleukin-6 (IL-6), IL-6 polarizes macrophages into the M2 phenotype. The dominant peritoneal tissue M2 macrophages, marked by upregulated Arg-1 expression, account for the attenuation of MGO-induced dedifferentiation of peritoneal mesothelial cells to maintain epithelial integrity.
Hypersurfaces of a Sasakian manifold - revisited
Authors: Deshmukh Sharief , Belova Olga , Turki Nasser Bin , Vîlcu Gabriel-Eduard 
Published: March 2021

AbstractWe study orientable hypersurfaces in a Sasakian manifold. The structure vector field ξ of a Sasakian manifold determines a vector field v on a hypersurface that is the component of the Reeb vector field ξ tangential to the hypersurface, and it also gives rise to a smooth function σ on the hypersurface, namely the projection of ξ on the unit normal vector field N. Moreover, we have a second vector field tangent to the hypersurface, given by $\mathbf{u}=-\varphi (N)$
u
=
−
φ
(
N
)
. In this paper, we first find a necessary and sufficient condition for a compact orientable hypersurface to be totally umbilical. Then, with the assumption that the vector field u is an eigenvector of the Laplace operator, we find a necessary condition for a compact orientable hypersurface to be isometric to a sphere. It is shown that the converse of this result holds, provided that the Sasakian manifold is the odd dimensional sphere $\mathbf{S}^{2n+1}$

S

2
n
+
1

. Similar results are obtained for the vector field v under the hypothesis that this is an eigenvector of the Laplace operator. Also, we use a bound on the integral of the Ricci curvature $Ric ( \mathbf{u},\mathbf{u} ) $
R
i
c
(
u
,
u
)
of the compact hypersurface to find a necessary condition for the hypersurface to be isometric to a sphere. We show that this condition is also sufficient if the Sasakian manifold is $\mathbf{S}^{2n+1}$

S

2
n
+
1

.
Uniqueness and concentration for a fractional Kirchhoff problem with strong singularity
Authors: Yu Shengbin , Chen Jianqing 
Published: March 2021

AbstractIn this paper, we consider the following fractional Kirchhoff problem with strong singularity: $$ \textstyle\begin{cases} (1+ b\int _{\mathbb{R}^{3}}\int _{\mathbb{R}^{3}} \frac{ \vert u(x)-u(y) \vert ^{2}}{ \vert x-y \vert ^{3+2s}}\,\mathrm{d}x \,\mathrm{d}y )(-\Delta )^{s} u+V(x)u = f(x)u^{-\gamma }, & x \in \mathbb{R}^{3}, \\ u>0,& x\in \mathbb{R}^{3}, \end{cases} $$

{

(
1
+
b

∫

R
3

∫

R
3

|
u
(
x
)
−
u
(
y
)

|
2

|
x
−
y

|

3
+
2
s

d
x

d
y
)

(
−
Δ
)

s

u
+
V
(
x
)
u
=
f
(
x
)

u

−
γ

,

x
∈

R
3

,

u
>
0
,

x
∈

R
3

,

where $(-\Delta )^{s}$

(
−
Δ
)

s

is the fractional Laplacian with $0< s<1$
0
<
s
<
1
, $b>0$
b
>
0
is a constant, and $\gamma >1$
γ
>
1
. Since $\gamma >1$
γ
>
1
, the energy functional is not well defined on the work space, which is quite different with the situation of $0<\gamma <1$
0
<
γ
<
1
and can lead to some new difficulties. Under certain assumptions on V and f, we show the existence and uniqueness of a positive solution $u_{b}$

u
b

by using variational methods and the Nehari manifold method. We also give a convergence property of $u_{b}$

u
b

as $b\rightarrow 0$
b
→
0
, where b is regarded as a positive parameter.
A Kirchhoff-type problem involving concave-convex nonlinearities
Authors: Gao Yuan , Liu Lishan , Luan Shixia , Wu Yonghong 
Published: March 2021

AbstractA Kirchhoff-type problem with concave-convex nonlinearities is studied. By constrained variational methods on a Nehari manifold, we prove that this problem has a sign-changing solution with least energy. Moreover, we show that the energy level of this sign-changing solution is strictly larger than the double energy level of the ground state solution.
Analysis of Atangana–Baleanu fractional-order SEAIR epidemic model with optimal control
Authors: Deressa Chernet Tuge , Duressa Gemechis File 
Published: March 2021

AbstractWe consider a SEAIR epidemic model with Atangana–Baleanu fractional-order derivative. We approximate the solution of the model using the numerical scheme developed by Toufic and Atangana. The numerical simulation corresponding to several fractional orders shows that, as the fractional order reduces from 1, the spread of the endemic grows slower. Optimal control analysis and simulation show that the control strategy designed is operative in reducing the number of cases in different compartments. Moreover, simulating the optimal profile revealed that reducing the fractional-order from 1 leads to the need for quick starting of the application of the designed control strategy at the maximum possible level and maintaining it for the majority of the period of the pandemic.
Modeling and analysis of taeniasis and cysticercosis transmission dynamics in humans, pigs and cattle
Authors: Mwasunda Joshua A. , Irunde Jacob I. , Kajunguri Damian , Kuznetsov Dmitry 
Published: March 2021

AbstractTaeniasis and cysticercosis pose a significant challenge to food safety and public health. Cysticercosis reduces the market value for pigs and cattle by making pork and beef unsafe for consumption. In this paper, a mathematical model for the transmission dynamics of taeniasis and cysticercosis in humans, pigs and cattle is formulated and analyzed. The analysis shows that both the disease free equilibrium (DFE) and the endemic equilibrium (EE) exist. To study the dynamics of the diseases, we derived the basic reproduction number $R_{0}$

R
0

by next generation matrix method. When $R_{0}< 1$

R
0

<
1
, the DFE is globally asymptotically stable whereas when $R_{0} > 1$

R
0

>
1
the EE is globally asymptotically stable. The normalized forward sensitivity index was used to determine sensitive parameters to the diseases. Humans’ recruitment rate, probability of humans’ infection with taeniasis and the defecation rate of taenia eggs by humans with taeniasis are the most positive sensitive parameters to diseases’ transmission whereas the human natural death rate is the most negative sensitive parameter. However, it is biologically unethical and not practical to increase human natural mortality rate for disease control. In this case, other parameters with negative sensitivity indices such as death rate of taenia eggs and proportions of unconsumed infected beef and pork can be considered for disease control. Generally, to control the diseases, more efforts should be made directed to reducing the number of humans who have taeniasis and defecate in the open environment. Also meat inspection and indoor keeping of cattle and pigs should be emphasized.
Appraising psychotherapy case studies in practice-based evidence: introducing Case Study Evaluation-tool (CaSE)
Authors: Kaluzeviciute Greta 
Published: March 2021

AbstractSystematic case studies are often placed at the low end of evidence-based practice (EBP) due to lack of critical appraisal. This paper seeks to attend to this research gap by introducing a novel Case Study Evaluation-tool (CaSE). First, issues around knowledge generation and validity are assessed in both EBP and practice-based evidence (PBE) paradigms. Although systematic case studies are more aligned with PBE paradigm, the paper argues for a complimentary, third way approach between the two paradigms and their ‘exemplary’ methodologies: case studies and randomised controlled trials (RCTs). Second, the paper argues that all forms of research can produce ‘valid evidence’ but the validity itself needs to be assessed against each specific research method and purpose. Existing appraisal tools for qualitative research (JBI, CASP, ETQS) are shown to have limited relevance for the appraisal of systematic case studies through a comparative tool assessment. Third, the paper develops purpose-oriented evaluation criteria for systematic case studies through CaSE Checklist for Essential Components in Systematic Case Studies and CaSE Purpose-based Evaluative Framework for Systematic Case Studies. The checklist approach aids reviewers in assessing the presence or absence of essential case study components (internal validity). The framework approach aims to assess the effectiveness of each case against its set out research objectives and aims (external validity), based on different systematic case study purposes in psychotherapy. Finally, the paper demonstrates the application of the tool with a case example and notes further research trajectories for the development of CaSE tool.
Antioxidant and antimalarial properties of Sophora exigua Craib. root extract in Plasmodium berghei-infected mice
Authors: Kaewdana Kantarakorn , Chaniad Prapaporn , Jariyapong Pitchanee , Phuwajaroanpong Arisara , Punsawad Chuchard 
Published: March 2021

AbstractBackgroundSophora exiguaCraib. is commonly used in Thailand to reduce fever and increase postpartum breast milk production in women who have hypogalactia. However, there has been no report on the antioxidant and antimalarial properties of this plant. This study aimed to investigate the antioxidant and antimalarial activities ofS. exiguaroot extract and to evaluate its acute toxicity in mice to confirm its safety.MethodsThe in vitro antioxidant activities were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide radical, and hydroxyl radical scavenging assays. The in vivo antioxidant activities were determined by detecting the malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in the livers of malaria-infected mice. The in vivo antimalarial activity was determined by Peters’ 4-day suppressive test in mice infected withPlasmodium bergheiANKA and orally administeredS. exiguaroot aqueous and ethanolic extracts at different doses (200, 400, and 600 mg/kg body weight). In addition, the acute oral toxicity of the plant extracts was assessed in mice at a dose of 2000 mg/kg body weight.ResultsThe ethanolic extract ofS. exiguaroot exhibited inhibition of DPPH radicals, superoxide anions, and hydroxyl radicals, with half maximal inhibitory concentration (IC50) values of 24.63 ± 1.78, 129.78 ± 0.65, and 30.58 ± 1.19 μg/ml, respectively. Similarly, research on the in vivo antioxidant activity indicated that the ethanolic extract ofS. exiguaroot exerted a stronger effect than the aqueous extract. The aqueous extract at doses of 200, 400, and 600 mg/kg had stronger antimalarial activity than the ethanolic extract. The aqueous extract at 600 mg/kg exhibited 60.46% suppression of parasitemia. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and blood urea nitrogen (BUN) were detected in the mice treated with 2000 mg/kg ethanolic extract, which was related to the results of histopathological analysis of liver tissue, showing ballooning degeneration of hepatocytes, diffuse hepatic hemorrhage, and infiltration of inflammatory cells.ConclusionsThis study demonstrated that the ethanolicS. exiguaroot extract possessed antioxidant properties, and the aqueous extract also had antimalarial activity. Therefore, this plant is an alternative source of new antioxidant and antimalarial agents.