bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dipyridamole Ameliorates Memory Impairment and Increases Hippocampal Calbindin Expression in Niemann Pick C1 Mice
Authors: Gaddini Lucia , Chiodi Valentina , Matteucci Andrea , Boussadia Zaira , Buée Luc , Eddarkaoui Sabiha , Blum David , Di Carlo Nazzareno , Raggi Carla , Di Benedetto Rita , Popoli Patrizia , Ferrante Antonella 
Published: December 2024

ABSTRACTNiemann Pick type C1 (NPC1) is a rare, fatal disorder characterized by endosomal lipid accumulation that leads to damage of both peripheral organs and central nervous system (cerebellum and hippocampus are especially affected). Currently, miglustat is the only approved drug for NPC1, thus the identification of new treatments is mandatory. We have previously demonstrated that the drug dipyridamole (DIP), an enhancer of adenosine signaling, can reduce the pathological phenotype in patient‐derived fibroblasts. In this paper, we evaluated the in vivo effects of DIP in NPC1 mice. Male and female NPC1nih mice were treated with DIP 30 mg/kg i.p. from 28 to 64 days of age. Motor function was assessed by Erasmus Ladder test, hippocampal cognitive decline by Novel Object Recognition test and brain pathology by immunofluorescence and biochemical assays. Peripheral pathology was evaluated by analyzing lipid accumulation in spleen and liver (HP‐TLC). In NPC1, mice DIP rescued recognition memory and increased hippocampal expression of calbindin. On the contrary, the drug was unable to improve motor function, cerebellar pathology and lipid accumulation in spleen and liver. Our results demonstrated that DIP selectively ameliorates the cognitive impairment in NPC1 mice. This drug could thus represent a valuable therapeutic tool to be used in combination with other treatments in NPC1.
Effect of nitrogen levels on grain yield and quality in improving mid‐season japonica rice varieties
Authors: Wang Chen , Jing Wenjiang , Fa Xiaotong , Gu Jiayi , Wang Weilu , Zhu Kuanyu , Zhang Weiyang , Gu Junfei , Liu Lijun , Wang Zhiqin , Zhang Jianhua , Zhang Hao 
Published: December 2024

AbstractBACKGROUNDNitrogen application is recognized as a principal factor influencing rice quality. However, there remains a paucity of research on the effects of different N levels on quality, particularly within the context of the improvement of rice varieties.RESULTSThis study examined 14 mid‐season japonica rice varieties cultivated in Jiangsu province over the past 80 years under five N application levels (0, 90, 180, 270, and 360 kg N ha−1). The results showed that yield increased steadily as varieties improved at all N levels. For varieties from the 1950s to the 1990s, yields initially rose and then declined as N application rates increased, peaking at 270 kg N ha−1. In contrast, modern varieties (post‐2000) exhibited a consistent increase in yield with higher N application rates. Fitted equations indicated that maximum yields were achieved at optimal N levels of 237–278 kg N ha−1 for varieties from the 1950s–1990s and 229.25 kg N ha−1 for post‐2000 varieties.As varieties improved, the content of brown, milled, and head milled rice, as well as albumen, gluten, and overall quality, increased. Conversely, chalkiness, protein content, gliadin and amylose content decreased, whereas gel consistency, breakdown, peak viscosity, and globulin showed no consistent pattern. Likewise, there was no consistent pattern in the tendency of starch to retrograde (as indicated by ‘setback’ values). Increasing N application rates enhanced the content of brown and milled rice, chalkiness, protein and its components, and the tendency of starch to retrograde (indicated by higher setback values). In contrast, amylose content, gel consistency, breakdown, peak viscosity, and overall taste quality declined with higher N levels.The study compared rice varieties with high yields (exceeding 10 t ha−1) and good comprehensive taste scores (above 52), revealing that modern varieties Wuyunjing 24, Lianjing 7, Yanjing 4038, and Nanjing 9108 performed exceptionally well with 180 kg N ha−1 and 270 kg N ha−1.CONCLUSIONModern varieties, with optimal N application and management, can achieve both high yield and good quality effectively. © 2024 Society of Chemical Industry.
Lack of Evidence for the Efficacy of Antifungal Medications to Treat Atopic Dermatitis: A Systematic Review
Authors: Andrade Luis F. , Ju Teresa , Abdi Parsa , Anderson Michael R. , Edwards Elise , Khalil Nicole , Burke Olivia , Jaguan Daniella , Silverberg Jonathan I. 
Published: December 2024

ABSTRACTBackgroundAtopic dermatitis (AD) is characterised by immune dysregulation and skin‐barrier dysfunction, which can predispose to microbial dysbiosis and skin infections. Fungi, particularly Malassezia, are common skin colonisers in AD patients and may exacerbate the condition. Previous studies on the efficacy of antifungal treatments for AD have shown inconsistent results.ObjectivesThis systematic review aims to evaluate the effectiveness of topical and oral antifungal therapies in treating AD.MethodsA systematic review was conducted following the PRISMA guidelines (PROSPERO ID: CRD42022338791). Databases searched included PubMed, MEDLINE, Embase, Scopus, LILACS, Cochrane, CINAHL, GREAT, and ClinicalTrials.gov. Inclusion criteria encompassed interventional studies using antifungal agents for AD, with outcomes such as SCORing Atopic Dermatitis (SCORAD).ResultsOf 35,591 studies obtained from the initial search, seven met the inclusion criteria. Topical antifungal treatments, such as sertaconazole, miconazole, and ciclopirox olamine, showed minimal efficacy in reducing AD severity when compared to placebo or hydrocortisone treatments. Oral antifungal treatments, including itraconazole and ketoconazole, demonstrated mixed results, with some studies showing modest improvements in SCORAD scores but overall lacking significant clinical benefit.ConclusionsThe systematic review found weak evidence supporting the efficacy of both topical and oral antifungal therapies for treating AD. Topical antifungals showed limited improvement and fewer adverse effects, while oral antifungals posed a higher risk of systemic adverse events without consistent efficacy. Based on these findings, antifungal treatments are not recommended for AD severity management alone other than for treatment of comorbid fungal and yeast infections. Future research should focus on larger sample sizes, standardised severity assessments, and comprehensive adverse event reporting to better evaluate antifungal treatments in AD.
NEDD4L inhibits epithelial‐mesenchymal transition in gastric cancer by mediating BICC1 ubiquitination
Authors: Duan Shaoyi , Tian Zhiliang , Hu Rong , Long Heng 
Published: December 2024

AbstractEpithelial‐mesenchymal transition (EMT) is a critical stage in the metastasis of gastric cancer (GC). Further clarification of the EMT process in GC is still needed. This study examined the effects of the NEDD4L/BICC1 axis on GC proliferation and the EMT process. Thirty GC patients were enrolled in this study to assess the expression of BICC1 and NEDD4L in tumor samples. A xenograft tumor model in mice was created to investigate BICC1's function in vivo. The proliferation, migration, and invasion of GC cells were evaluated using colony formation, transwell, and wound healing assays. Western blot determined the expression levels of EMT‐associated proteins. Co‐immunoprecipitation (Co‐IP) elucidated the mechanism by which NEDD4L regulates BICC1. BICC1 was found to be overexpressed in tumors. Additionally, BICC1 knockdown inhibited the growth of GC cells in vivo and prevented their migration, invasion, proliferation, and EMT. Furthermore, BICC1 activated the PI3K/AKT pathway, which facilitated cancer progression. Tumor tissues and GC cells exhibited low expression levels of NEDD4L. Conversely, NEDD4L overexpression promoted the ubiquitination and degradation of BICC1 protein, thereby inhibiting GC cell proliferation, migration, invasion, and EMT processes. Our study demonstrated that NEDD4L acts as a tumor suppressor in GC, while BICC1 functions as a pro‐tumorigenic factor. The NEDD4L/BICC1 axis plays a significant role in the metastasis and progression of GC.
The impact of the muscle mass‐to‐fat ratio on the prognosis of patients undergoing pancreaticoduodenectomy for pancreatic cancer
Authors: Xu Long‐Jie , Zhang Sheng‐Qiang , Cao Chun 
Published: December 2024

AbstractTo evaluate the relationship between the muscle mass‐to‐fat ratio (MMFR) at the third lumbar spine (L3) and overall survival (OS) as well as related complications after pancreaticoduodenectomy (PD) for pancreatic cancer. Patients who underwent PD for pancreatic cancer between March 2017 and May 2023 at the Second Affiliated Hospital of Soochow University were included. Muscle mass and fat content at the L3 were measured by computed tomography. The specific formula that was used to calculate the MMFR was total abdominal muscle area/(subcutaneous adipose tissue area + visceral adipose tissue area), and the optimal cutoff values of the MMFR based on receiver operating characteristic curves were 0.688 for males and 0.382 for females. Patient characteristics were collected, and multivariate analyses were used to evaluate the impact of the MMFR on prognosis. Kaplan–Meier survival curves and log‐rank tests were used to compare OS between the high‐MMFR and low‐MMFR groups. On the basis of the optimal cutoff values, 191 patients were divided into two groups, with 91 patients in the low‐MMFR group and 100 patients in the high‐MMFR group. The incidence of POPF was significantly greater in the low‐MMFR group than in the high‐MMFR group. According to multivariate analysis, the MMFR was an independent factor associated with POPF and OS. Patients with low MMFRs had significantly shorter OS and a greater POPF incidence than did those with high MMFRs. The MMFR is an independent predictor of POPF and affects the OS of patients undergoing PD for pancreatic cancer.
Intrapolyp Steroid Injection for Nasal Polyposis: A Systematic Review and Network Meta‐Analysis
Authors: Albazee Ebraheem , Abu‐Zaid Ahmed , Althaidy Mubarak , Alqunaee Marwan 
Published: December 2024

ObjectiveTo conduct a systematic review and network meta‐analysis to evaluate the safety and efficacy of intrapolyp steroid injection compared with oral steroids, nasal steroid wash, nasal steroid spray, and a control group in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).Data SourcesPubMed, Scopus, Web of Science, Embase, and CENTRAL.Review MethodsBoth randomized and non‐randomized clinical trials were included. For risk of bias assessment, we used the RoB‐2 and ROBINS‐I tools. Our outcomes focused on safety and efficacy, including rates of visual disturbance and bleeding, as well as improvements in nasal polyps evaluated through three domains: endoscopic, radiologic, and patient‐reported assessments. Safety data were pooled as events (%), while efficacy data were pooled as mean difference (MD) or standardized mean difference (SMD).ResultsEight clinical trials involving 579 patients were analyzed. The pooled analyses showed low event rates for visual disturbances (event rate = 0.64%, 95% CI [0.00%, 2.23%]) and bleeding (event rate = 0.61%, 95% CI [0.00%, 2.25%]). Additionally, intrapolyp steroid injections were found to be comparable with oral steroids, with no statistically significant differences. Moreover, intrapolyp steroid injections demonstrated some superiority over nasal sprays, nasal washes, and the control group.ConclusionThis network meta‐analysis confirms that intrapolyp steroid injections have a favorable safety and efficacy profile as a viable management option for CRSwNP. The injections showed comparable efficacy with oral steroids and demonstrated certain advantages over other treatments, such as nasal sprays and washes. Further research with larger sample sizes and standardized protocols are needed. Laryngoscope, 2024
Analysis of Potentials and Limitations of Safe Drinking Water in Rural Systems: A Colombian Perspective
Authors: Colmenares‐Cruz Ramiro Andrés , Plazas‐Leguizamón Nubia Zoraida , Arias‐Rodríguez Luis Alejandro , Moreno‐López Nidia Milena , Barrera‐Siabato Andrea Isabel , Fonseca‐Carreño Jorge Armando 
Published: December 2024

ABSTRACTConsidering the meaning of the hydric resource regarding the formation of territories and its connection to agriculture development, present review paper aims to analyze the actual context of rural water systems in Colombia. For this, scientific information was acquired using Scopus through the search formula: “sustainability AND aqueduct” as well as information gather from national and regional public institutions websites with the intention to stablish an international and national context using meta‐analysis PRISMA method. To determine the service cycle of the search formula, information was subjected to lineal regression by considering the determination coefficient (R
2) and analyzing information taking as a reference the inflection point. Like that, each resulted document from the search were studied to then select those with grater relation towards the goals. Background information allowed to understand that aqueducts are fundamental organizations for sustainable development offering a reasonable access to clean water through its management and also showing that, regardless of existent challenges around its administration, it is necessary to implement policies that offer articulated and comprehensive solutions with participant elements as it is outlined on Colombia's National Development Plan, aiming to guarantee sustainable and equal access to water source.
Intercropping With Green Manure Regulates Microbial Community Structure and Improves Tea Quality by Changing Soil Available Nutrients Under Organic Management
Authors: Wang Biao , Huang Xinhui , Chen Jianfeng , Fu Libo , Chen Yuanquan , Gao Wangsheng , Sui Peng 
Published: December 2024

ABSTRACTIntercropping with green manure is recognized as a sustainable and ecological agricultural practice that regulates soil microbial activity and promotes plant growth. Despite its potential benefits, the impact of tea plants intercropping green manure on organic plantations remains largely unexplored. This study primarily evaluated the effects of intercropping summer green manure and winter green manure (TSR: tea intercropping soybean + ryegrass; TMR: tea intercropping mung bean + radish; TSC: tea intercropping soybean + common vetch; TM: tea plant monoculture, consider as control) on soil microbial community composition, tea quality, and bacterial function in an organic tea plantation. Relative to TM, TMR improved soil physical structure by decreasing the soil penetration resistance and bulk density by 30.4% and 9.30% (p < 0.05), thus creating a conducive environment for microbial growth and activity. The composition and beta diversity of microbial communities have markedly differed after intercropping, attributed to changes in soil available nutrients, enzyme activities, and soil compaction. Intercropping increased the relative abundance of key microbial phyla, including Acidobacteriota, Firmicutes, Chytridiomycota, and Rozellomycota. Notably, TSR and TSC enhanced nitrogen fixation function by enriching beneficial microorganisms, such as Bradyrhizobium and Clostridium_beijerinckii, which were mediated by soil available potassium. The content of amino acids in tea leaves was increased by 20.2% under TMR. The partial least squares path model further revealed that intercropping with green manure improved tea quality by decreasing soil penetration resistance and increasing soil available phosphorus. Overall, intercropping with green manure can effectively reshape the microbial community and improve tea quality by affecting the soil environment, underscoring the importance of adopting intercropping strategies in organic plantations.
Commercial Social Capital and Social Conflict: Historical Evidence From China
Authors: Xiao Weiwei , Yi Xing , Zhong Yuqing , Yin Xiuxiu 
Published: December 2024

ABSTRACTSocial stability is a crucial prerequisite for the prosperity and development of a country or region, and social conflict has long been a focal topic in academia. However, few studies examine the impact of commercial social capital on social conflict. This paper addresses this gap by investigating the influence of shanghui (chambers of commerce) in the late Qing Dynasty, a form of commercial social capital, on regional social conflict. Utilizing prefecture‐level panel data from 1902 to s and employing a DID approach, we empirically explore the impact of shanghui on regional social conflict during this period. The results show that the establishment of shanghui significantly increased the likelihood of regional social conflict, and this effect remains robust across a variety of robustness tests. As a form of commercial social capital, shanghui effectively promoted the formation of merchant networks, facilitating collective action among merchants to safeguard their interests. Further historical evidence suggests that the impact of shanghui on regional social conflict is primarily evident in three areas: (1) supporting social revolutions, particularly the Revolution of 1911; (2) resisting actions by foreign merchants and the Qing government that threatened their interests, exemplified by the Boycott of American Goods and the Railway Protection Movement; and (3) siding with merchants in labor disputes, thus leading to worker strikes.
Harnessing the gut microbiome to enhance cancer immunotherapy: Current advances and future directions in microbiota‐based therapeutic strategies
Authors: Zhao Binyan , Zhou Bailing , Li Qing , Su Chunyan , Ma Jing , Yang Li 
Published: December 2024

AbstractCancer immunotherapies, developed on the basis of research into tumor escape mechanisms, manipulate the immune system to reactivate an antitumor immune response to recognize and attack cancer cells. Immunotherapy has demonstrated promising and exciting outcomes in the treatment of many cancers, yet not all patients experience favorable responses. The gut microbiota plays a critical role in modulating the host immune system, influencing responses to cancer immunotherapy. Research has increasingly demonstrated that specific microbial communities can increase the efficacy of immune checkpoint inhibitors, although the mechanisms involved remain under investigation. However, a clear gap exists in the understanding of how bacterial therapies can be further optimized for cancer treatment. This review provides an in‐depth analysis of current bacterial therapies used in clinical trials as adjuncts to cancer immunotherapy, summarizing common research approaches and technologies utilized to investigate gut microbiota interactions with the immune system. Additionally, advanced strategies for modifying bacteria, including genetic engineering, surface modifications, and the development of bacterial derivatives, are discussed. By synthesizing these findings, this review highlights the potential of microbiota‐based therapies to improve immunotherapy outcomes and offers future directions for improving clinical applications.
CMMSE: New Properties of Auto‐Wave Solutions in Activator‐Inhibitor Reaction‐Diffusion Systems With Fractional Derivatives
Authors: Datsko Bohdan , Gafiychuk Vasyl 
Published: December 2024

ABSTRACTIn this article, we analyze new properties of auto‐wave solutions in fractional reaction‐diffusion systems. These new properties arise due to a change in fractional derivative order and do not occur in systems with classical derivatives. It is shown that the stability of steady‐state solutions and their evolution are mainly determined by the eigenvalue spectrum of a linearized system and the fractional derivative order. It is also demonstrated that the basic properties of auto‐wave solutions in fractional‐order systems can essentially differ from those in standard systems. The results of the linear stability analysis are confirmed by computer simulations of the generalized fractional van der Pol–FitzHugh–Nagumo mathematical model. A common picture of possible instabilities and auto‐wave solutions in time‐fractional two‐component activator‐inhibitor systems is presented.
Numerical Analysis of Stabilizer‐Free Weak Galerkin Finite Element Method for Time‐Dependent Differential Equation Under Low Regularity
Authors: Liu Xuan , Zou Yongkui , Wang Yiying , Zhou Chenguang , Wang Huimin 
Published: December 2024

ABSTRACTIn this article, we focus on investigating the optimal convergence order of error estimates for the stabilizer‐free weak Galerkin finite element method for a second‐order time‐dependent differential equation under low regularity assumptions. In most of the existing literature on stabilizer‐free weak Galerkin finite element methods, the exact solution is usually assumed to have at least regularity so as to achieve convergence rates. But in many applications, the exact solution has only regularity, and hence the existing error analysis is no longer applicable. Our objective is to build a theoretical framework for filling in this gap. Our key idea is to interpolate an approximation between the exact solution and the stabilizer‐free weak Galerkin approximation as an intermediate auxiliary step. Based on this, the optimal convergence order of error estimates is proved to be of . Finally, we present several numerical experiments on uniform triangulations and square partitions to demonstrate the theoretical convergence properties.
Numerical simulation of damage under thermal effect in drilling CFRP
Authors: Chen Chen , Zhao Qing , Shi Zhanli , Ning Qiao 
Published: December 2024

AbstractCarbon fiber reinforced plastics (CFRP) is sensitive to temperature, serious drilling damage occurs due to the accumulation of cutting heat during the drilling process. In order to explore the thermal effect on drilling damage, in this study, a stress–strain model of CFRP with thermal effect is developed first. According to the calculation results, it can be obtained that the initial failure strength of single layer of CFRP reduces by 22.97% as the temperature increasing from 160.68 to 185.44°C. Furtherly, simulation model of drilling CFRP is established based on the proposed constitutive model, according to the simulated results, it can be obtained that the intralaminar damage is mainly presented as fiber tensile failure and matrix tensile failure, and the damage variable of matrix tensile failure increases evidently with the increase of drilling temperature. Moreover, the damage of hole wall is more serious under higher drilling temperature, which is presented as pitting defects with the fiber cutting angle of 90°–135°.Highlights
A stress–strain model of CFRP with thermal effect is proposed.
Initial failure strength of single layer of CFRP is obtained.
Simulation model of drilling CFRP is developed based on the proposed constitutive model.
Matrix tensile failure is more sensitive to temperature.